bluuebunny/crossref_metadata_2025 huggingface dataset:
Madde Yazma Eğitiminin Özel Okulda Çalışan İlköğretim İngilizce Öğretmenlerinin Maddenin Kalitesini Değerlendirmeye İlişkin Yeterliklerine Etkisi
Authors: KARTAL Münibe , İLGÜN DİBEK Münevver
Published: March 2022

Kaliteli madde yazma eğitiminin özel okulda çalışan ilköğretim İngilizce öğretmenlerinin madde yazma yeterliliklerine olan etkisini belirlemek amacıyla yapılan bu araştırmada deneysel desenlerden tek grup ön-test son-test desen kullanılmıştır. Araştırmanın çalışma grubunu kolay ulaşılabilir örnekleme yöntemi kullanılarak seçilmiş özel okulda ilköğretim kademesinde görev yapan 14 İngilizce öğretmeni oluşturmaktadır. Araştırmada veri toplama aracı olarak alan yazın taranarak oluşturulmuş olan kaliteli madde yazma kriterlerinin ölçüldüğü 19 maddeden oluşan bir test oluşturmaktadır. Bu test, madde yazmayla ilgili hizmet içi eğitim verilmeden önce ön test ve hizmet içi eğitim verildikten sonra son test olarak İngilizce öğretmenlerine uygulanmıştır. Madde yazma eğitimi öncesi mezun olunan fakülte türüne göre öğretmenlerin ön test puanları açısından anlamlı bir fark olup olmadığını belirlemek amacıyla Mann Whitney U-testi, ön test puanlarının meslekte geçirdiği süreye göre de farklılaşıp farklılaşmadığını belirlemek amacıyla Kruskal Wallis H-testi ve ön test ile son test puanları arasındaki farkın anlamlılığını test etmek amacıyla Wilcoxon işaretli sıralar testi kullanılmıştır. Öğretmenlerin madde yazma yeterliliklerinin mezun oldukları fakülte türüne ve meslekte geçirdiği süreye göre farklılaşmadığı bulunmuştur. Bunun yanı sıra, verilen eğitimin öğretmenlerin madde yazma yeterliliklerini geliştirmede önemli bir etkisinin olduğu sonucuna ulaşılmıştır.
INDIA IN UNSC: A CLAIM FOR A PERMANENT SEAT
Authors: Sabavat Ravi
Published: March 2022

India has been associated with the UN since its formation in 1945.It began its contribution as a part of Common wealth Nations and went on to contribute after independence till now. In its 75 year long and rich association, it becomes important to study its successes and failures to assess the veracity of it staking claim for a permanent membership in the UNSC. India’s contribution at diplomatic level has been that of interplay between the alignment of international principles on security and peace and its own interests over a period of time. Often big and small powers including the UNGA turned to India for its support.
AN INVESTIGATION INTO FOREIGN STUDENTS’ CHOICE OF COURSES OF HIGHER EDUCATION IN INDIA: A CASE STUDY OF SHARDA UNIVERSITY
Authors: Das Pankaj , Zubair Fatima Lawan , Yahuza Aminu
Published: March 2022

The study investigated foreign students’ choice of courses in higher education in India at Sharda University. A sample of 30 students was selected randomly. A self-developed questionnaire with 14 items was used as a data collection instrument. Descriptive statistics were used for data analysis which included the use of tables, frequency, cumulative frequency, percentages, and pie charts. The results of the present study indicated that the majority of the foreign students are pursuing their bachelor's degree and they belong to the science stream. It was also found that the choice of courses among foreign students of Sharda University is based on their personal interests. It was revealed that there is a relationship between students’ choice of courses and their socioeconomic background, and also gender does have influenced on their choice of courses. It was recommended among others that guidance and counseling services should be provided to the students, parents should not force students into courses they do not want to major in, and institutions of higher education should allow students to choose courses according to their interests.
Deep Low-frequency Radio Observations of A2256. I. The Filamentary Radio Relic
Authors: Rajpurohit K. , van Weeren R. J. , Hoeft M. , Vazza F. , Brienza M. , Forman W. , Wittor D. , Domínguez-Fernández P. , Rajpurohit S. , Riseley C. J. , Botteon A. , Osinga E. , Brunetti G. , Bonnassieux E. , Bonafede A. , Rajpurohit A. S. , Stuardi C. , Drabent A. , Brüggen M. , Dallacasa D. , Shimwell T. W. , Röttgering H. J. A. , Gasperin F. de , Miley G. K. , Rossetti M.
Published: March 2022

We present deep and high-fidelity images of the merging galaxy cluster A2256 at low frequencies using the upgraded Giant Metrewave Radio Telescope (uGMRT) and LOw-Frequency ARray (LOFAR). This cluster hosts one of the most prominent known relics with a remarkably spectacular network of filamentary substructures. The new uGMRT (300–850 MHz) and LOFAR (120–169 MHz) observations, combined with the archival Karl G. Jansky Very Large Array (VLA; 1–4 GHz) data, allowed us to carry out the first spatially resolved spectral analysis of the exceptional relic emission down to 6″ resolution over a broad range of frequencies. Our new sensitive radio images confirm the presence of complex filaments of magnetized relativistic plasma also at low frequencies. We find that the integrated spectrum of the relic is consistent with a single power law, without any sign of spectral steepening, at least below 3 GHz. Unlike previous claims, the relic shows an integrated spectral index of −1.07 ± 0.02 between 144 MHz and 3 GHz, which is consistent with the (quasi)stationary shock approximation. The spatially resolved spectral analysis suggests that the relic surface very likely traces the complex shock front, with a broad distribution of Mach numbers propagating through a turbulent and dynamically active intracluster medium. Our results show that the northern part of the relic is seen edge-on and the southern part close to face-on. We suggest that the complex filaments are regions where higher Mach numbers dominate the (re)acceleration of electrons that are responsible for the observed radio emission.
Further Evidence for the Minifilament-eruption Scenario for Solar Polar Coronal Jets
Authors: Baikie Tomi K. , Sterling Alphonse C. , Moore Ronald L. , Alexander Amanda M. , Falconer David A. , Savcheva Antonia , Savage Sabrina L.
Published: March 2022

We examine a sampling of 23 polar-coronal-hole jets. We first identified the jets in soft X-ray (SXR) images from the X-ray telescope (XRT) on the Hinode spacecraft, over 2014–2016. During this period, frequently the polar holes were small or largely obscured by foreground coronal haze, often making jets difficult to see. We selected 23 jets among those adequately visible during this period, and examined them further using Solar Dynamics Observatory’s (SDO) Atmospheric Imaging Assembly (AIA) 171, 193, 211, and 304 Å images. In SXRs, we track the lateral drift of the jet spire relative to the jet base’s jet bright point (JBP). In 22 of 23 jets, the spire either moves away from (18 cases) or is stationary relative to (4 cases) the JBP. The one exception where the spire moved toward the JBP may be a consequence of line-of-sight projection effects at the limb. From the AIA images, we clearly identify an erupting minifilament in 20 of the 23 jets, while the remainder are consistent with such an eruption having taken place. We also confirm that some jets can trigger the onset of nearby “sympathetic” jets, likely because eruption of the minifilament field of the first jet removes magnetic constraints on the base-field region of the second jet. The propensity for spire drift away from the JBP, the identification of the erupting minifilament in the majority of jets, and the magnetic-field topological changes that lead to sympathetic jets, all support or are consistent with the minifilament-eruption model for jets.
Three new cryptic species of South Asian Cnemaspis Strauch, 1887 (Squamata, Gekkonidae) from Karnataka, India
Authors: Khandekar Akshay , Thackeray Tejas , Agarwal Ishan
Published: March 2022

We describe three new small-bodied, cryptic species of south AsianCnemaspisbelonging to themysoriensisandgoaensisclades from the Mysore Plateau and the Western Ghats biodiversity hotspot in Karnataka, peninsular India; and provide a key to members of each clade, besides providing the first ND2 sequence data forC. ranganaensis.Cnemaspis tigrissp. nov.from Kaiwara in Karnataka is a member of themysoriensisclade and can be morphologically distinguished from all six described members of the clade in a number of meristic characters and subtle differences in colouration, beside ≥ 12.1–23.4 % uncorrected pairwise ND2 sequence divergence.Cnemaspis sakleshpurensissp. nov.from Sakleshpur andC. vijayaesp. nov.from Coorg, both in the Western Ghats of Karnataka, are members of thegoaensisclade and are easily diagnosed from all three described members of the clade in meristic characters beside 5.2–14.8 % divergence from described members of the clade and 14.6 % from each other in uncorrected pairwise ND2 sequence divergence. The discovery of these new species from two different clades and biogeographic regions is not surprising, given the steep rise in the number of species ofCnemaspisknown from peninsular India. Comprehensive geographic sampling in conjunction with molecular and morphological data is essential to understand the true diversity and distributional ranges of species within this ancient clade of gekkonid lizards.
Le répertoire romanesque publié en Normandie
Authors: Mounier Pascale
Published: March 2022

Pour mesurer la contribution des presses normandes à la Bibliothèque bleue en matière de romans, il faut faire l’inventaire des œuvres et des éditions concernées, proposer des repères temporels au sujet des bornes et des étapes de l’activité éditoriale locale et voir les particularités matérielles des éditions. Une telle enquête est susceptible de faire connaître les romans publiés en Normandie en soi et d’aider à discerner le degré de singularité des stratégies des imprimeurs normands par rapport à celles de leurs homologues troyens.
La fabrique du travail social. Entre braconnage, bricolage et innovation
Authors: Lavigne Adeline
Published: March 2022

Le travail(leur) social, dans la pleine dimension de la technicité de sa pensée comme de son agir professionnel, se voit animé par les lectures-territoires qu’il arpente et dont il est traversé. Une interdépendance manifeste, sujet de croissance perpétuelle, entre « bibliothèque intérieure » et quête de professionnalisation, prend ainsi naissance au creux de l’éducateur-lecteur, siège d’une confluence unissant braconnage, bricolage et innovation, au service d’un « non-savoir » glorieux.
La médiation : concept, modèles et approches
Authors: Ngan Jules-Alain
Published: March 2022

La médiation est un nouveau métier de l’intervention sociale basé sur la communication éthique et la neutralité d’un tiers sans pouvoir décisionnel. Elle permet de prévenir et de gérer des conflits interpersonnels ou entre des individus et une institution. Mais ce concept est souvent confondu avec d’autres (négociation, conciliation, transaction, etc.). L’objectif de cette note de synthèse est donc de clarifier le concept de médiation et d’examiner ses modèles (pragmatique, attributif, spécialisé et professionnel) et approches (horizontale et verticale). La médiation s’applique à divers champs (école, famille, société, etc.), la qualité principale du médiateur étant sa capacité à communiquer, à créer un cadre propice à la recherche de solutions viables à l’amiable.
Une attention pour le précoce dans la rencontre psychanalytique avec un enfant
Authors: Bydlowski Sarah
Published: March 2022

La figure de l’enfant précoce est une expression actuellement fort répandue. Elle interroge l’accueil de la temporalité propre du développement, de la place du corps pulsionnel de l’enfant, de l’infantile en soi et de ses manifestations inconscientes. Par le récit des premières consultations d’un très jeune enfant en présence de ses parents, nous illustrons l’idée qu’une précocité du fonctionnement de l’enfant pourrait conduire trop rapidement à une indication de psychothérapie, au détriment de la compréhension suffisante des échanges inconscients et conscients entre l’enfant et ses parents, et de leur cheminement thérapeutique nécessaire. Prendre le temps suffisant de l’élaboration en consultation avant toute proposition de séparation pour un traitement individuel se révèle indispensable, en regard tant du développement de l’enfant en pleine construction psychique que de l’infantile et des blessures narcissiques parentales.
Origines et évolution de la méthode de la psychothérapie psychanalytique corporelle (PPC)
Authors: Dechaud-Ferbus Monique , Pélissier Christine
Published: March 2022

La PPC est une pratique psychanalytique utilisant plus particulièrement la perception et la sensorimotricité comme médiation corporelle dans la relation entre le patient et l’analyste quand le langage verbal échoue dans sa fonction médiatrice. L’historique de la méthode de Psychothérapie Psychanalytique corporelle et son évolution nous ont permis de montrer avec plusieurs points de vue de collègues, l’intérêt de l’utilisation des paramètres de l’organisation somato-psychique pour travailler à partir de l’originaire avec des patients présentant des pathologies réfractaires à la cure type. Quelle que soit l’organisation psychique des patients, l’originaire étant actif toute la vie nous pouvons constater l’intérêt pour tout un chacun du travail dans ces régions archaïques de notre fonctionnement. Les recherches se poursuivent aujourd’hui dans le cadre de l’Association pour l’Enseignement de la Psychothérapie Psychanalytique Corporelle (AEPPC).
Innovative Opportunities for Nurse Practitioner Education Uncovered by the Pandemic
Authors: Taylor Tracey L. , Remo Elizabeth , Hay Brittany , Johansson Marcia , Bricker Christina , Maguire Denise
Published: March 2022

Background:

The coronavirus disease 2019 pandemic resulted in the abrupt withdrawal of clinical sites for nurse practitioner (NP) students during the Spring semester of 2020. This situation necessitated the identification of innovative clinical opportunities to ensure advanced practice nursing students met course objectives and program requirements.

Method:

This article describes innovative clinical opportunities that met the needs of the community, including those impacted by the pandemic, and enabled NP students' progression toward completing clinical requirements.

Results:

Participation in these unique opportunities provided more than 130 NP students with meaningful clinical experiences to increase competence in the care of vulnerable populations and communities during a public health crisis.

Conclusion:

Experiences supported competency development in the areas of leadership, clinical management, population health and infection control, policy and advocacy, informatics, telehealth, and ethical considerations while providing essential services to the community. These innovative clinical opportunities may be useful for graduate clinical programs worldwide.

[
J Nurs Educ
. 2022;61(3):153–155.]
Cultivating Clinical Judgment in Pharmacological Decision-Making Through Reflection on Practice
Authors: Davis Rebecca G. , Wood Felecia G.
Published: March 2022

Background:

Competent clinical judgment about pharmacological therapies by nurses is essential for safe medication outcomes. This study examined the impact of postclinical pharmacology-focused reflective debriefing sessions on clinical judgment in prelicensure senior nursing students.

Method:

A nonrandomized repeated measures design was used to compare clinical judgment of students who participated in an additional learning activity with students who did not. Data were collected using Lasater's Clinical Judgment Rubric.

Results:

Within-groups analysis of variance demonstrated statistically significant increases in clinical judgment scores at mid- and late-semester timepoints for the entire cohort of participants (
n
= 128). However, analysis of covariance showed no statistically significant differences in the clinical judgment scores for the intervention (
n
= 62) and control (
n
= 66) groups.

Conclusion:

Clinical experiences provide opportunities for prelicensure students to develop clinical judgment about pharmacological therapies. Nurse educators must implement and evaluate strategies to foster this process.

[
J Nurs Educ
. 2022;61(3):143–146.]
Dual Collegiate Roles—The Lived Experience of Nursing Student Athletes
Authors: Engelke Eileen C. , Frederickson Keville
Published: March 2022

Background:

Teamwork and communication, characteristics learned through playing college sports, can precipitate a sense of wonder in the lived experiences of nursing students who played a college sport.

Method:

A phenomenological study was conducted to understand the meaning of the collegiate roles of the nursing student and the student athlete. These roles carry different sets of responsibilities, social contacts, and physical and emotional demands. Thirteen practicing nurses who played a college sport during their nursing program were interviewed.

Results:

Data analysis revealed four essential themes that described the meaning of their experience: athletic identity, perseverance, advocates and adversaries, and belongingness. Results suggest participation in college sports creates a sense of belonging that assists in the transition into college.

Conclusion:

Although nursing students may be deterred from coordinating academics and athletics, this study indicates it is possible and may even have benefits, both academically and during students' transition into practice.

[
J Nurs Educ
. 2022;61(3):117–122.]
Ethics Education for Nurses: Foundations for an Integrated Curriculum
Authors: Robichaux Catherine , Grace Pamela , Bartlett Jennifer , Stokes Felicia , Saulo Lewis Mileva , Turner Martha
Published: March 2022

Background:

Complexity in health care environments causes practice problems. Nurses bear responsibility for recognizing, addressing, and preventing ethical problems. Inadequacies in ethics education are partly to blame and contribute to nurse moral distress, attrition, and suboptimal care. Foundational curricula structures adequate for developing nurse moral agency are needed.

Method:

The state of the science of ethics education in nursing was explored in-depth by a subcommittee of the American Nurses Association Ethics Advisory Board. A framework based in nursing goals was designed by nurse ethics experts to address ethics education across levels of curricula and practice. Rest's four-component model of moral behavior structures guidelines.

Results:

The model captures three facets of nurse moral agency: necessary characteristics, knowledge and skills, and motivation. A case is provided to illustrate its utility.

Conclusion:

This framework provides the means to meet the profession's goal of preparing ethically competent nurses who will exercise moral agency.

[
J Nurs Educ
. 2022;61(3):123–130.]
A smooth Levenberg-Marquardt method without nonsingularity condition for wLCP
Authors: He Xiaorui ,   College of Mathematics and Statistics, Xinyang Normal University, Xinyang 464000, China, Tang Jingyong
Published: March 2022

In this paper we consider the weighted Linear Complementarity Problem (wLCP). By using a smooth weighted complementarity function, we reformulate the wLCP as a smooth nonlinear equation and propose a Levenberg-Marquardt method to solve it. The proposed method differentiates itself from the current Levenberg-Marquardt type methods by adopting a simple derivative-free line search technique. It is shown that the proposed method is well-defined and it is globally convergent without requiring wLCP to be monotone. Moreover, the method has local sub-quadratic convergence rate under the local error bound condition which is weaker than the nonsingularity condition. Some numerical results are reported.
Optimal control model of tumor treatment in the context of cancer stem cell
Authors: Haddad Ghassen ,   IPT-BIMSLab (LR16IPT09), Tunis El Manar University, 1002 Tunis, Tunisia, Kebir Amira , Raissi Nadia , Bouhali Amira , Miled Slimane Ben ,   Sorbonne Université, Laboratoire Jacques-Louis Lions, Paris, France,   IPEIT, Tunis University, Tunisia,   Mohammed V University of Rabat — um5a Department of Mathematics, Morocco
Published: March 2022

We consider cancer cytotoxic drugs as an optimal control problem to stabilize a heterogeneous tumor by attacking not the most abundant cancer cells, but those that are crucial in the tumor ecosystem. We propose a mathematical cancer stem cell model that translates the hierarchy and heterogeneity of cancer cell types by including highly structured tumorigenic cancer stem cells that yield low differentiated cancer cells. With respect to the optimal control problem, under a certain admissibility hypothesis, the optimal controls of our problem are bang-bang controls. These control treatments can retain the entire tumor in the neighborhood of an equilibrium. We simulate the bang-bang control numerically and demonstrate that the optimal drug scheduling should be administered continuously over long periods with short rest periods. Moreover, our simulations indicate that combining multidrug therapies and monotherapies is more efficient for heterogeneous tumors than using each one separately.
Impact of participation in the World Robot Olympiad on K-12 robotics education from the coach's perspective
Authors: Zhang Yicong , Lu Yanan , Bao Xianqing , Chiang Feng-Kuang
Published: March 2022

The integration of robotics education with science, technology, engineering, and mathematics (STEM) education has a great potential in future education. In recent years, numerous countries have hosted robotic competitions. This study uses a mixed research method to explore the coaches' views on student participation in the World Robot Olympiad (WRO) by incorporating the questionnaire surveys and interviews conducted at the 2019 WRO finals in Hungary. By quantitative and qualitative analyses, coaches generally agreed that participation in the WRO improved students' STEM learning skills and cultivated their patience and resilience in handling challenging tasks.
Sex Influences Age-Related Changes in Natural Antibodies and CD5+ B-1 Cells
Authors: Webster Sarah E , Ryali Brinda , Clemente Michael J , Tsuji Naomi L , Holodick Nichol E
Published: March 2022

Natural Abs are primarily produced by B-1 cells and are essential for protection against Streptococcus pneumoniae. The incidence and mortality rate for pneumococcal infection increases dramatically after age 65, disproportionately affecting males in both human and murine systems. To date, there is a significant gap in our understanding of the relationship among sex, aging, natural IgM efficacy, and the natural IgM repertoire. Our investigation demonstrates that the protective capacity of serum IgM against pneumococcal infection is maintained in IgM obtained from aged female mice but absent in IgM from aged male mice. To understand this difference in protective capacity, we examined serum Ig, discovering that the protective change was not associated with shifts in levels of phosphorylcholine (PC)- or pneumococcal capsular polysaccharide serotype 3–specific IgM. Interestingly, we observed that aged females have an increase in the total number of CD5+ B-1 cells, higher serum IL-5 levels, and a larger percentage of aged female CD5+ B-1 cells that express CD86 as compared with aged males. Furthermore, single-cell IgM repertoire analysis from peritoneal PC+, splenic PC+, and bone marrow CD5+ B-1 cell subsets demonstrated greater diversity with age and a higher level of germline status in female mice than previously observed in studies of aged male mice. Aged female CD5+ B-1 cells also expressed higher levels of transcripts associated with cell activity and self-renewal, such as Nanog and Hmga2. Taken together, these data indicate that females maintain a more diverse and active CD5+ B-1 cell pool and natural IgM repertoire, which has implications for sex-related susceptibility to infection and disease.
Cannabinoid CB2receptors and spinal microglia are implicated in tingenone-mediated antinociception in mice
Authors: Moura Clarice C.V. , dos Santos Rafaela S. , Duarte Lucienir P. , Galdino Giovane
Published: March 2022

Objective:

To investigate the antinociceptive effect of tingenone on inflammatory pain, as well as and the involvement of the cannabinoid receptors type 2 (CB2) and spinal microglia in this process.

Methods:

Male Swiss mice were subjected to inflammatory pain induced by intraplantar injection of carrageenan. The nociceptive threshold was measured by von Frey filaments test. Tingenone was administered orally 60 min before carrageenan injection. To evaluate the involvement of CB2 receptor, endocannabinoids, and microglia, AM630 (a CB2 receptor antagonist), MAFP (an inhibitor of an enzyme that hydrolyses endocannabinoids), and minocycline (a microglial inhibitor) were given intrathecally 20 min before tingenone administration. In addition, an immunofluorescence assay was used to evaluate CB2 receptor and CD11B (a microglial marker) expression in the spinal cord dorsal horn.

Results:

Tingenone significantly reduced carrageenan-induced hyperalgesia, which was reversed by pretreatment with AM630. MAFP and minocycline potentiated and prolonged the tingenone- induced antinociception. CD11B expression was increased in the spinal cord dorsal horn of mice with inflammatory pain pretreated with tingenone, which was reduced by AM630, MAFP, and minocycline.

Conclusions:

CB2 receptors and endocannabinoids participate in the tingenone-induced antinociception which may involve the inhibition of microglia at spinal level.
Morin attenuates L-arginine induced acute pancreatitis in rats by downregulating myeloperoxidase and lipid peroxidation
Authors: Rehman Kanwal , Rashid Ummara , Jabeen Komal , Akash Muhammad Sajid Hamid
Published: March 2022

Objective:

To explore the therapeutic role of morin against L-arginine-induced acute pancreatitis in rats.

Methods:

The group 1 received two intraperitoneal injections of normal saline, and groups 2-4 were given two intraperitoneal injections of L-arginine (250 mg/100 g body weight) at 1 h interval to induce acute pancreatitis. Subsequently, group 2 received no further treatment while groups 3 and 4 were treated with morin (30 mg/kg) and diclofenac sodium (30 mg/kg), respectively. Blood glucose and serum levels of insulin, α-amylase, malondialdehyde, myeloperoxidase, alanine aminotransferase, aspartate aminotransferase and cholesterol were measured. Moreover, histopathological study was carried out to investigate the effect of morin treatment on physiology of the pancreas.

Results:

L-arginine significantly altered the level of blood glucose and serum levels of insulin, α-amylase, malondialdehyde, myeloperoxidase, alanine aminotransferase, aspartate aminotransferase and cholesterol. Treatment with morin or diclofenac sodium significantly improved the levels of these biomarkers. Furthermore, morin showed more significant effect than diclofenac sodium. Histopathological analysis verified that morin protected the pancreas from deleterious effects of L-arginine.

Conclusions:

Morin plays a protective role against L-arginine- induced acute pancreatitis via reducing lipid peroxidation and tissue inflammation, and attenuating acute pancreatitis-associated alteration in insulin secretion and glucose metabolism.
Natural compounds as potential inhibitors of SARS-CoV-2 main protease
Authors: Mishra Amaresh , Pathak Yamini , Kumar Anuj , Mishra Surabhi Kirti , Tripathi Vishwas
Published: March 2022

Objective:

To explore natural compounds as potential inhibitors against main protease (Mpro) of SARS-CoV-2.

Methods:

In the current study, systematic molecular docking analysis was conducted using AutoDock 4.2 to determine the binding affinities and interactions between natural compounds and Mpro. Selected natural compounds were further validated using a combination of molecular dynamic (MD) simulations and molecular mechanic Poisson-Boltzmann surface area (MM/PBSA) free energy calculations.

Results:

Out of twenty natural compounds, four natural metabolites namely, amentoflavone, guggulsterone, puerarin, and piperine were found to have strong interaction with Mpro of SARS-CoV-2 based on docking analysis. During MD simulations, all four natural compounds bound to Mpro at 50 ns and MM/G/P/BSA free energy calculations showed that all four shortlisted ligands had stable and favorable energies with strong binding to Mpro protein.

Conclusions:

Guggulsterone is a potential inhibitor of COVID- 19 main protease Mpro. Further in vitro and pre-clinical studies are needed.
Bounds for the distribution of the Frobenius traces associated to products of non-CM elliptic curves
Authors: Cojocaru Alina Carmen , Wang Tian
Published: March 2022

Let
$g \geq 1$
be an integer and let
$A/\mathbb Q$
be an abelian variety that is isogenous over
$\mathbb Q$
to a product of g elliptic curves defined over
$\mathbb Q$
, pairwise non-isogenous over
$\overline {\mathbb Q}$
and each without complex multiplication. For an integer t and a positive real number x, denote by
$\pi _A(x, t)$
the number of primes
$p \leq x$
, of good reduction for A, for which the Frobenius trace
$a_{1, p}(A)$
associated to the reduction of A modulo p equals t. Assuming the Generalized Riemann Hypothesis for Dedekind zeta functions, we prove that
$\pi _A(x, 0) \ll _A x^{1 - \frac {1}{3 g+1 }}/(\operatorname {log} x)^{1 - \frac {2}{3 g+1}}$
and
$\pi _A(x, t) \ll _A x^{1 - \frac {1}{3 g + 2}}/(\operatorname {log} x)^{1 - \frac {2}{3 g + 2}}$
if
$t \neq 0$
. These bounds largely improve upon recent ones obtained for
$g = 2$
by Chen, Jones, and Serban, and may be viewed as generalizations to arbitrary g of the bounds obtained for
$g=1$
by Murty, Murty, and Saradha, combined with a refinement in the power of
$\operatorname {log} x$
by Zywina. Under the assumptions stated above, we also prove the existence of a density one set of primes p satisfying
$|a_{1, p}(A)|>p^{\frac {1}{3 g + 1} - \varepsilon }$
for any fixed
$\varepsilon>0$
.
On a topological Ramsey theorem
Authors: Kubiś Wiesław , Szeptycki Paul
Published: March 2022

We introduce natural strengthenings of sequential compactness, the r-Ramsey property for each natural number
$r\geq 1$
. We prove that metrizable compact spaces are r-Ramsey for all r and give examples of compact spaces that are r-Ramsey but not
$(r+1)$
-Ramsey for each
$r\geq 1$
(assuming Continuum Hypothesis (CH) for all
$r>1$
). Productivity of the r-Ramsey property is considered.
Lactobacillus plantarum as Bio-Control Agent during Egg Incubation of African Catfish (Clarias gariepinus) – Effects on Microbial Loads and Water Quality Parameters
Authors: Diyaolu Daniel Olusegun
Published: March 2022

This study evaluated the heterotrophic bacteria and fungi loads and water quality parameters when Lactobacillus plantarum was employed as bio-control agent during egg incubation of Clarias gariepinus. The L. plantarum cells were inoculated into incubating water in 6-litre bowl at bacterial concentration of 2×103, 2×106 and 2×109 cfu L-1. Bowls with 1 ppt tetracycline solution and with no test bacteria / drug served as positive and negative controls respectively. 3 g of C. gariepinus fertilized eggs were incubated in these bowls under static water condition for 30 hours at room temperature, after which hatchability was determined. The water in each bowl was analyzed before, during and after egg incubation. The results indicated that all L. plantarum treatment groups recorded significantly (p<0.05) reduced Enterobacteriaceae and fungi counts in the incubating water, with the optimum concentration recorded at 2×106 cfu L-1. There were significant reductions (p<0.05) in the dissolved oxygen and pH of water at 30 hours of incubation when compared with the values obtained at 10 hour of incubation in all experimental groups. The fertilized eggs hatched in all treatment groups except those inoculated with 2×109 cfu L-1 L. plantarum, while hatchlings from positive control (tetracycline solution) groups were observed to be less viable than the probiotic-treatment and negative control (non-probiotic treatment) groups. It can be concluded from this study that addition of 2×106 cfu L-1 of L plantarum into incubating water reduced microbial loads, but did not improve water quality parameters (dissolved oxygen and pH) and hatchability of C. gariepinus eggs.
Simultaneous production of cellulase and amylase by Aspergillus fumigatus IB-A1
Authors: Ezea Ifeanyi Boniface , Murata Yoshinori , Ogbonna James Chukwuma
Published: March 2022

Utilization of agricultural wastes for production of useful metabolites requires hydrolysis using both cellulase and amylase enzymes. We isolated Aspergillus fumigatus IB-A1 and evaluated its ability to simultaneously produce both cellulase and amylase. Although the isolate could produce both cellulase and amylase from either soluble starch or carboxymethyl cellulose, amylase activity was higher with soluble starch while cellulase activity was higher when carboxymethyl cellulose was used as the sole carbon source. With a mixture of carboxymethyl cellulose and soluble starch, both the amylase and cellulase activities increased with increase in the ratio of soluble starch. The optima ratio of carboxymethyl cellulose to soluble starch for cellulase and amylase activities were 0.7:0.3, and 0.4 to 0.6 respectively. For practical application, the optimum ratio of carboxymethyl cellulose to soluble starch in the production medium depends on the relative composition of cellulose and starch in the substrate to be hydrolyzed. The isolate was also able to efficiently produce both amylase and cellulase from cassava peel. With 10 g/L cassava peel, the cellulase and amylase activities were 6.122± 0.320 U/ml/min and 4.342± 0.210 U/ml/min respectively. When the cells were immobilized on loofa sponge and subjected to alternating air phase- liquid phase culture, cellulase and amylase production from cassava peel increased to 8.106± 0.620 U/ml/min and 5.206± 1.24 U/ml/min respectively. The optimum ratio of the air phase to the liquid phase was 3 hours of air phase to 21 hours of liquid phase.
Influencing Role of Cultural Diversity on Destination Brand Equity, Mombasa County, Kenya
Authors: Mafuta Lawrence Mukoyani , Maingi Shem Wambugu , Khayiya Rosemarie
Published: March 2022

Product diversity and the producer are inseparable and crucial in choosing cultural products within a region. The study sought to understand cultural diversity in influencing destination brand equity in Mombasa County. Cross-sectional mixed-method design was used with a sample size of 350 respondents. Simple stratified random sampling was used with the optimum allocation method to select cultural resource sites. Stirling index was used where Simpson measured variation of cultural resources and balanced 'ex-ante' of various cultural products into a single indicator. The results show that cultural resources influence the destination brand equity efficacy on main brand aspects. The destination brand equity includes design, communication, packaging, guests' experiences, personality, and presumed liaison at the destination. As such, cultural products alone will not influence the destination brand equity if they are not consumed. Policies for marketing cultural products to promote consumption are required.
Towards Making Tourism Education Programmes More Inclusive: From The Perceptive of Disabled People
Authors: Makuyana Tawanda , du Plessis Engelina
Published: March 2022

The study explores the existence of the seemingly latent potential, ability, and willingness of disabled people to participate in tourism education programmes by using the social model of disability. Consequently, unveiling the cause and effective intervention thereof. A qualitative research design enabled in-depth face-to-face interviews and Facebook group discussions collected data from disabled people. This research method allowed the researchers to gain relevant information from the real-life experiences of participants. A difference in opinion was observed between participants already enrolled at education institutions and not enrolled participants. However, all believe they have the potential, ability, and willingness to participate in tourism education programmes. The literature shows tourism education facilities as overlooking biases, stigmatisation and discriminatory practices to disabled people, deeming them unable, incapable and unwilling to study for tourism degrees. While results show effort to accommodate and enrol disabled participants, challenges and struggles remain due to underlying obstacles. Clearly, the social model of disability exposed that if the potential, ability, and willingness of disabled people to participate in tourism education programmes remain invisible to tourism educators, the participation, involvement and thriving of disabled people may continue to be compromised. Therefore, the articles provide steps to enhance inclusion.
Econometric Analysis of the Relationship Between Tourism Revenues, Inflation and Economic Growth: The Case of Morocco and South Africa
Authors: Huseynli Nigar
Published: March 2022

The aim of this study is to determine the relationship between international tourism revenues, inflation rates and economic growth of Morocco and South Africa between. The Multiple Linear Regression Model was used to measure whether there is a significant relationship between dependent and independent variables and how the variables affect economic growth. The data used in the analysis were obtained from the World Bank and include annual data. During the analysis process, a series of assumption tests were made to reveal the significance of the model. The model was established by taking the logarithm of the dependent variable. The VIF test was used to measure that the independent variables were not related to each other, the Breusch-Godfrey LM test was applied to examine whether there was autocorrelation between the error terms, and the Shapiro-Wilk W test, which was another assumption, was applied to measure the normal distribution of the error terms. As a result of the latest multiple linear regression analysis, it was determined that there was a significant relationship between the variables of both countries. In both countries, the increase in international tourism revenues affects economic growth positively, but the increase in inflation affects economic growth negatively.
OPTIMALISASI PENDIDIKAN KOMANDO MARINIR MENINGKATKAN PROFESIONALISME PRAJURIT KORPS MARINIR MENDUKUNG TUGAS TNI ANGKATAN LAUT
Authors: Martin M S Manurung  , Werijon  , Roni Saputra
Published: March 2022

Pelaksanaan Pendidikan Komando (Dikko) Marinir saat ini telah mampu membentuk prajurit-prajurit Korps Marinir yang sanggup melaksanakan tugas-tugas yang diberikan oleh satuan atas baik yang bersifat Operasi Militer Perang (OMP) maupun Operasi Militer Selain Perang (OMSP). Akan tetapi, perubahan yang sangat cepat di bidang ilmu pengetahuan dan tehnologi menuntut adanya penyesuaian yang menyeluruh dalam penyelenggaraan pendidikan di lingkungan TNI AL untuk memperkecil gap ketertinggalan dan kemungkinan kegagalan dalam pelaksanaan tugas pokok. Perkembangan Ilmu pengetahuan dan teknologi pada era sekarang ini telah memberikan pengaruh yang sangat besar terhadap kemampuan dan daya pikir sumber daya manusia, sehingga pola penyelenggaran pendidikan yang tetap mengacu kepada pelaksanaan tugas pokok TNI di lapangan harus mampu memanfaatkan situasi tersebut sebagai kemampuan positif yang dapat dikembangkan melalui Dikko Marinir. Seiring dengan kemajuan ilmu pengetahuan dan teknologi serta perkembangan lingkungan strategis baik global, regional maupun nasional telah merubah spektrum ancaman yang semula bersifat konvensional menjadi ancaman multidimensional. Pembahasan dilakukan dengan menggunakan landasan pemikiran dihadapkan pada faktor-faktor yang mempengaruhi, dengan memperhatikan peluang dan kendala yang ada dalam rangka mencapai kondisi Pendidikan Komando Marinir yang diharapkan. Untuk mewujudkan hal ini, diperlukan rumusan kebijakan, strategi dan upaya-upaya oleh berbagai pihak yaitu Kepala Staf TNI Angkatan Laut, Komandan Kodiklatal, Komandan Korps Marinir dan Gubernur AAL melalui metode Kebijakan, Standarisasi, edukasi, Sosialisasi, dan evaluasi. Apabila optimalisasi Pendidikan Komando Marinir dapat mendukung peningkatan profesionalisme prajurit Korps Marinir, maka akan mendukung pelaksanaan tugas pokok TNI AL.
PENINGKATAN KAPASITAS KELEMBAGAAN DESA TANGGAP BENCANA
Authors: Hilman Yusuf Adam , Khoirurrosyidin Khoirurrosyidin , Nasution Robby Darwis
Published: March 2022

Praktik pemberdayaan yang dilakukan berangkat dari kondisi kelembagaan pemerintahan desa, yang masih mencari formula yang tepat dalam rangka memperkuat kapasitasnya dalam membangun sistem penanggulangan bencana di level pemerintah desa,  supaya dapat memunculkan bentuk kelembagaan desa tangga bencana yang tepat. Penguatan kelembagaan desa tanggap bencana berusaha mengujikan permodelan dengan memperkuat kelembagaan desa, melalui beberapa tahapan, diantaranya: 1). Komunikasi dengan pemerintah desa 2). FGD dan musyawarah Permodelan desa tanggap bencana, 3). Rekomendasi hasil FGD dan Musyawarah. Pemerintah desa melihat bahwa kelembagaan desa tanggap bencana dirasakan sangat di perlukan, beberapa hal telah disepakati, terkait pembentukan kelembagaan Tangguh bencana, persoalan anggaran, dna juga partisipasi masyarakat, yang harus dilanjutkan dalam tahap selanjutnya
PENINGKATAN KAPASITAS STUDI KELAYAKAN BISNIS PADA BUMDES DAN UMKM DI SUNGAI LANGKA KABUPATEN PESAWARAN
Authors: Muslimin  , Sri Hasnawati  , Nindya Puspitasari Dalimunthe  , Rialdi Azhar
Published: March 2022

The aim of this paper to describe how to enhance technical skill of Bumdes and SMEs in developing business financial feasibility analysis. Specifically, this activity aims to identify local economic potentials as a foundation to foster SME’s growth by facilitating developing financial plan of their business. Participatory approach is used to transfer of knowledge of the training. As the pandemic situation, social media is used to account skill required. By using pre and post test to evaluate the training, the results show that the participants need to continuous training to apply the steps of feasibility study analysis. Even there is a progress in developing the materials technically, the score is still lower to transform the aspect financially. Financial literate dissemination is still needed to enhance financial skills of the participants.
Pengentasan Kemiskinan Melalui Social Preneur Bagi Ibu-Ibu PKK
Authors: Maliki Budi Ilham , Nashrudin Achmad
Published: March 2022

Kegiatan ini hendak membantu dalam upaya pengentasan kemiskinan melalui pendekatan pemberdayaan dan gender, yakni pemberdayaan ibu-ibu PKK dengan menumbuh kembangkan social preneur pada organisasi dan kegiatan PKK. Kegiatan ini akan memberikan pelatihan ketrampilan sesuai peminatan mitra, agar mitra   mampu   menghasilkan  produk   unggulan   yang   memiliki   nilai   ekonomis   dan dibutuhkan pasar. Produk tersebut selain untuk dipasarkan juga untuk dikonsumsi sendiri, dan mengurangi beban pengeluaran mitra dalam membiayai konsumsi rumah tangga. Untuk  menumbuhkembangkan social preneur, yang bertujuan sosial (pengentasan kemiskinan), diberikan pula pelatihan motivasi kewirausahaan dan ketrampilan manajerial kewirausahaan, yang mencakup manajemen produksi, manajemen  keuangan,  akuntansi  sederhana  dan  manajemen  pemasaran.  Luara kegiatan ini adalah: 1) Pengurangan beban biaya konsumsi barang kebutuhan rumah tangga pada keluarga ibu-ibu PKK mitra,(2) Terbentuknya social preneur Ibu-Ibu PKK RW mitra yang mampu memberikan penghasilan tambahan kepada keluarga anggota PKK, dan 3) Terciptanya produk barang kebutuhan rumah tangga dan konveksi hasil produksi PKK mitra yang layak dipasarkan
PENINGKATAN PERANCANGAN SISTEM INFORMASI MERCHANDISE INSIDE LOMBOK BERBASIS WEBSITE MENGGUNAKAN API WHATSAPP
Authors: Negara Habib Ratu Perwira , Ahmad Ahmad , Aditya I Komang Wira
Published: March 2022

Aims to be able to help PT. Lombok Media Utama (Inside Lombok) in managing all its merchandise catalogs on the website and making it easier for customers who want to buy merchandise to input the purchase format using the WhatsApp API. This activity is in the form of making a website using the prototyping method and training carried out by the team by providing training to the Inside Lombok admin staff in the form of directions on the flow of using this website application, the participants involved are the inside Lombok admin staff. From the results obtained after testing using BlackBox Testing and evaluation of satisfaction, quite satisfactory results were obtained where the admin managed to manage merchandise products easily, and customers could also use the features on the website smoothly to fill in the format with the Whatsapp API feature to be more efficient
PELATIHAN PENINGKATAN LITERASI DALAM PENGGUNAAN MEDIA PEMBELAJARAN KOMIK DI SDS ANGKASA 4 JAKARTA TIMUR
Authors: Septiani Eka , Sari Nur Indah , Rusmana Indra Martha
Published: March 2022

Reading skills play an important role in our lives because knowledge is acquired through reading. Therefore, this skill must be mastered by students well from an early age. Unfortunately, in the 21st century, the literacy ability of students has decreased. The general objective of this activity is to use comic-based learning media in order to help improve the literacy culture of students. The specific purpose of this activity is to increase the creativity of teachers in developing learning media, namely comic-based. The benefit of this activity for the school is to produce a comic that can help them improve the literacy movement in their school. The benefit of the activity for teachers is to develop their creativity in producing a work that can improve to literacy of students
Influence of Sugars, Sugar Alcohols and Their Combinations on Environmentally Significant Cellulase Production Under Liquid State Fermentation
Authors: Verma Nitin , Kumar Vivek
Published: March 2022

To expand the range of soluble carbon sources for enzyme production by the microbial system, we investigated the ability of different sugars in cellulase production. Carbon sources play a vital role in cell metabolism and the synthesis of cellulase. Although the insoluble cellulosic materials are considered the most effective natural inducers for cellulase production by microorganisms in terms of both enzyme yield and productivity, their insolubility causes many problems and presents a major drawback that is partly responsible for the high cost of cellulase production. Mostly, the insolubility of sugar polymer leads to difficult and complex fermentation operations, including sterilization, cell biomass measurement, mixing and aeration of the fermentation broth, continuous feeding/sampling, and subsequent enzyme purification. Second, cellulase gets absorbed into the solid cellulose surface, leading to enzyme loss. The present paper gives a comparative view on the utility of pure sugars (lactose, CMC, sucrose, maltose, cellobiose, xylose, trehalose, arabinose) and sugar alcohols (sorbitol, mannitol) on cellulase production by various fungal strains. It also describes the blending effect of sugars as well as sugar alcohols on cellulase production by fungal strains.
APROXIMACIONES DEL MÉTODO PEPS EN BENEFICIO DE LAS PYMES PARA UN MEJOR CONTROL DE INVENTARIO
Authors: Rodríguez García Gustavo Adolfo
Published: March 2022

Establecer un método de inventarios para una empresa es una las partes mas fundamentales que se deben de hacer para poder tener un control sobre la mercancías adquirida así como la mercancía que sale, un control efectivo en el inventario nos proporciona seguridad sobre nuestras finanzas y sobre todo mejora la rentabilidad de la empresa, en esta investigación describiremos como el método PEPS que significa primeras entradas y primeras salidas se desarrolla para ofrecer una mejor eficiencia en el control de los inventarios sobre todo en las pymes debido a que como pequeñas empresas muchas no aplican el método adecuado para poder tener un control de sus productos y así evitar pérdidas financieras.