bluuebunny/crossref_metadata_2025 huggingface dataset:
Projecting the Impact of SARS-CoV-2 Variants and the Vaccination Program on the Fourth Wave of the COVID-19 Pandemic in South Korea
Authors: Shim Eunha
Published: July 2021

Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently administered in South Korea; however, vaccine supply is limited. Considering constraints in vaccine supply and the emergence of variant strains, we evaluated the impact of coronavirus disease (COVID-19) vaccination program in reducing incidence, ICU hospitalization, and deaths in South Korea. We developed an age-structured model of SARS-CoV-2 transmission parameterized with Korean demographics and age-specific COVID-19 outcomes. Using our model, we analyzed the impact of the COVID-19 vaccination program during the fourth wave of the pandemic in South Korea in reducing disease burden. We projected that the vaccination program can reduce the overall attack rate to 3.9% from 6.9% without vaccination, over 150 days, starting from 5 July 2021. The highest relative reduction (50%) was observed among individuals aged 50–59 years. Vaccination markedly reduced adverse outcomes, such as ICU hospitalizations and deaths, decreasing them by 45% and 43%, respectively. In the presence of the Delta variant, vaccination is expected to reduce the overall attack rate to 11.9% from 26.9%. Our results indicate that the impact of vaccination can be substantially affected by the emergence of SARS-CoV-2 variants. Furthermore, herd immunity is unlikely to be achieved with the potential emergence of the Delta variant, inconsistent with the blueprint of the South Korean government.
A Cross-Cultural Comparison of the Effects of Alcohol Mixed with Energy Drink (AMED) Consumption on Overall Alcohol Consumption and Related Consequences
Authors: Benson Sarah , Johnson Sean J. , Alford Chris , Scholey Andrew , Verster Joris C.
Published: July 2021

There is a growing body of scientific literature examining the effects of alcohol mixed with energy drink (AMED) on alcohol consumption and related negative consequences, such as risky behavior or negative health effects. It is unknown whether differences in cultural context may influence these AMED effects. The current cross-cultural study compared the data of N = 6881 students from The Netherlands (N = 4424), UK (N = 1594), and Australia (N = 863). Demographics, alcohol consumption, its consequences, and motives for AMED consumption were assessed. Analyses included (a) between-groups comparison of AMED and alcohol only (AO) consumers, (b) within-subjects comparison of AMED and AO occasions among AMED consumers only, and (c) comparisons between the three countries. The between-groups analysis revealed that AMED consumers drink more alcohol than AO consumers (p < 0.001). AMED consumers differed from AO consumers in many other aspects. For example, AMED consumers were significantly more often a smoker and had higher risk-taking scores. Within subject analysis among AMED consumers showed that significantly less alcohol was consumed on AMED, compared to AO occasions (p < 0.001). These findings were observed for both typical drinking occasions and the past month’s heaviest drinking occasion, and were consistent across the three countries. Comparisons between countries revealed that on both AMED and AO occasions, the UK sample consumed significantly more alcohol than the Australian and Dutch samples. Across countries, neutral motives such as ‘I like the taste’ and ‘I wanted to drink something else’ were the most frequently reported motives for consuming AMED. The most notable difference between the countries was the finding that consuming AMED ‘To get drunk’ was endorsed significantly more often among the UK sample (45.6%) than the Australian (31.2%) and Dutch (8.0%) samples. Negative alcohol-related consequences were significantly less frequently reported for AMED occasions compared to AO occasions. Some country-specific consequences of AMED consumption were observed, but these were more likely related to characteristics of the country and their drinking culture (e.g., the Australian sample reported more often driving a car after AMED consumption compared to the other countries, and this pattern of results was also found for AO occasions). In conclusion, there were limited differences between countries with regard to demographics of consumers and motives for AMED consumption, but the UK sample consumed significantly more alcohol and reported the highest frequency of negative alcohol related consequences. Consistent across countries was the observation that AMED consumers consume significantly less alcohol on their past month heaviest AMED drinking occasion, compared to their past month heaviest AO drinking occasion.
A Miniaturized Microbe-Silicon-Chip Based on Bioluminescent Engineered Escherichia coli for the Evaluation of Water Quality and Safety
Authors: Sciuto Emanuele Luigi , Corso Domenico , Libertino Sebania , van der Meer Jan Roelof , Faro Giuseppina , Coniglio Maria Anna
Published: July 2021

Conventional high throughput methods assaying the chemical state of water and the risk of heavy metal accumulation share common constraints of long and expensive analytical procedures and dedicated laboratories due to the typical bulky instrumentation. To overcome these limitations, a miniaturized optical system for the detection and quantification of inorganic mercury (Hg2+) in water was developed. Combining the bioactivity of a light-emitting mercury-specific engineered Escherichia coli—used as sensing element—with the optical performance of small size and inexpensive Silicon Photomultiplier (SiPM)—used as detector—the system is able to detect mercury in low volumes of water down to the concentration of 1 µg L−1, which is the tolerance value indicated by the World Health Organization (WHO), providing a highly sensitive and miniaturized tool for in situ water quality analysis.
Encountering Parents Who Are Hesitant or Reluctant to Vaccinate Their Children: A Meta-Ethnography
Authors: Fernández-Basanta Sara , Lagoa-Millarengo Manuel , Movilla-Fernández María-Jesús
Published: July 2021

(1) Background: Health professionals play an important role in addressing parents who are hesitant or reluctant to immunise their children. Despite the importance of this topic, gaps remain in the literature about these experiences. This meta-ethnography aimed to synthesise the available body of qualitative work about the care experiences of community and hospital health professionals in encounters with parents hesitant or reluctant to vaccinate their children. The aim is to provide key information for the creation of strategies that address vaccine hesitancy or refusal and ensure public trust in vaccination programs, which are required in a pandemic context such as the current one. (2) Methods: Noblit and Hare’s interpretive meta-ethnography of 12 studies was followed. A line of argument synthesis based on a metaphor was developed. (3) Results: The metaphor “The stone that refuses to be sculpted”, accompanied by three themes, symbolises the care experiences of health professionals in their encounters with parents that hesitate or refuse to vaccinate their children. (4) Conclusions: The creation of clearer communication strategies, the establishment of a therapeutic alliance, health literacy and the empowerment of parents are recommended. The incorporation of health professionals in decision making and the strengthening of multidisciplinary teams interacting with such parents are also included.
Modeling of the Long-Term Epidemic Dynamics of COVID-19 in the United States
Authors: Huang Derek , Tao Huanyu , Wu Qilong , Huang Sheng-You , Xiao Yi
Published: July 2021

Coronavirus 2019 (COVID-19) is causing a severe pandemic that has resulted in millions of confirmed cases and deaths around the world. In the absence of effective drugs for treatment, non-pharmaceutical interventions are the most effective approaches to control the disease. Although some countries have the pandemic under control, all countries around the world, including the United States (US), are still in the process of controlling COVID-19, which calls for an effective epidemic model to describe the transmission dynamics of COVID-19. Meeting this need, we have extensively investigated the transmission dynamics of COVID-19 from 22 January 2020 to 14 February 2021 for the 50 states of the United States, which revealed the general principles underlying the spread of the virus in terms of intervention measures and demographic properties. We further proposed a time-dependent epidemic model, named T-SIR, to model the long-term transmission dynamics of COVID-19 in the US. It was shown in this paper that our T-SIR model could effectively model the epidemic dynamics of COVID-19 for all 50 states, which provided insights into the transmission dynamics of COVID-19 in the US. The present study will be valuable to help understand the epidemic dynamics of COVID-19 and thus help governments determine and implement effective intervention measures or vaccine prioritization to control the pandemic.
The Incidence and Predictors of Solid- and Hematological Malignancies in Patients with Giant Cell Arteritis: A Large Real-World Database Study
Authors: Dar Lior , Ben-Shabat Niv , Tiosano Shmuel , Watad Abdulla , McGonagle Dennis , Komaneshter Doron , Cohen Arnon , Bragazzi Nicola Luigi , Amital Howard
Published: July 2021

Background: The association between giant cell arteritis (GCA) and malignancies had been widely investigated with studies reporting conflicting results. Therefore, in this study, we aimed to investigate this association using a large nationwide electronic database. Methods: This study was designed as a retrospective cohort study including GCA patients first diagnosed between 2002–2017 and age, sex and enrollment time-matched controls. Follow-up began at the date of first GCA-diagnosis and continued until first diagnosis of malignancy, death or end of study follow-up. Results: The study enrolled 7213 GCA patients and 32,987 age- and sex-matched controls. The mean age of GCA diagnosis was 72.3 (SD 9.9) years and 69.1% were women. During the follow-up period, 659 (9.1%) of GCA patients were diagnosed with solid malignancies and 144 (2.0%) were diagnosed with hematologic malignancies. In cox-multivariate-analysis the risk of solid- malignancies (HR = 1.12 [95%CI: 1.02–1.22]), specifically renal neoplasms (HR = 1.60 [95%CI: 1.15–2.23]) and sarcomas (HR = 2.14 [95%CI: 1.41–3.24]), and the risk of hematologic malignancies (HR = 2.02 [95%CI: 1.66–2.47]), specifically acute leukemias (HR = 1.81 [95%CI: 1.06–3.07]), chronic leukemias (HR = 1.82 [95%CI: 1.19–2.77]), Hodgkin’s lymphomas (HR = 2.42 [95%CI: 1.12–5.20]), non-Hodgkin’s-lymphomas (HR = 1.66: [95%CI 1.21–2.29]) and multiple myeloma(HR = 2.40 [95%CI: 1.63–3.53]) were significantly increased in GCA patients compared to controls. Older age at GCA-diagnosis (HR = 1.36 [95%CI: 1.25–1.47]), male-gender (HR = 1.46 [95%CI: 1.24–1.72]), smoking (HR = 1.25 [95%CI: 1.04–1.51]) and medium-high socioeconomic status (HR = 1.27 [95%CI: 1.07–1.50]) were independently associated with solid malignancy while age (HR = 1.47 [95%CI: 1.22–1.77]) and male-gender (HR = 1.61 [95%CI: 1.14–2.29]) alone were independently associated with hematologic- malignancies. Conclusion: our study demonstrated higher incidence of hematologic and solid malignancies in GCA patients. Specifically, leukemia, lymphoma, multiple myeloma, kidney malignancies, and sarcomas. Age and male gender were independent risk factors for hematological malignancies among GCA patients, while for solid malignancies, smoking and SES were risk factors as well.
From Mattering to Mattering More: ‘Goods’ and ‘Bads’ in Ageing and Innovation Policy Discourses
Authors: Greubel Carla , Moors Ellen H. M. , Peine Alexander
Published: July 2021

This paper provides an empirical ethics analysis of the goods and bads enacted in EU ageing and innovation policy discourses. It revolves around a case study of the persona Maria, developed as part of the EU’s Active and Healthy Ageing Policies. Drawing on Pols’ empirical ethics as a theoretical and methodological approach, we describe the variety of goods (practices/situations to be strived for) and bads (practices/situations to be avoided) that are articulated in Maria’s persona. We analyse how certain ideas about good and bad ageing—those associated with the use of sophisticated technologies—come to matter more in the solutions proposed for Maria and the framing of her unmet needs, while others which were initially seen as relevant and that describe her dreams, fears and interactions, are marginalised. The paper adds to existing studies of ageing and technology by analysing specific practices that render visible how the idea of technology and data sharing as evidently the right path towards futures of (good) ageing, comes to prevail.
Essential Roles of PPARs in Lipid Metabolism during Mycobacterial Infection
Authors: Tanigawa Kazunari , Luo Yuqian , Kawashima Akira , Kiriya Mitsuo , Nakamura Yasuhiro , Karasawa Ken , Suzuki Koichi
Published: July 2021

The mycobacterial cell wall is composed of large amounts of lipids with varying moieties. Some mycobacteria species hijack host cells and promote lipid droplet accumulation to build the cellular environment essential for their intracellular survival. Thus, lipids are thought to be important for mycobacteria survival as well as for the invasion, parasitization, and proliferation within host cells. However, their physiological roles have not been fully elucidated. Recent studies have revealed that mycobacteria modulate the peroxisome proliferator-activated receptor (PPAR) signaling and utilize host-derived triacylglycerol (TAG) and cholesterol as both nutrient sources and evasion from the host immune system. In this review, we discuss recent findings that describe the activation of PPARs by mycobacterial infections and their role in determining the fate of bacilli by inducing lipid metabolism, anti-inflammatory function, and autophagy.
Oligomerization and Nitration of the Grass Pollen Allergen Phl p 5 by Ozone, Nitrogen Dioxide, and Peroxynitrite: Reaction Products, Kinetics, and Health Effects
Authors: Backes Anna T. , Reinmuth-Selzle Kathrin , Leifke Anna Lena , Ziegler Kira , Krevert Carola S. , Tscheuschner Georg , Lucas Kurt , Weller Michael G. , Berkemeier Thomas , Pöschl Ulrich , Fröhlich-Nowoisky Janine
Published: July 2021

The allergenic and inflammatory potential of proteins can be enhanced by chemical modification upon exposure to atmospheric or physiological oxidants. The molecular mechanisms and kinetics of such modifications, however, have not yet been fully resolved. We investigated the oligomerization and nitration of the grass pollen allergen Phl p 5 by ozone (O3), nitrogen dioxide (NO2), and peroxynitrite (ONOO–). Within several hours of exposure to atmospherically relevant concentration levels of O3 and NO2, up to 50% of Phl p 5 were converted into protein oligomers, likely by formation of dityrosine cross-links. Assuming that tyrosine residues are the preferential site of nitration, up to 10% of the 12 tyrosine residues per protein monomer were nitrated. For the reaction with peroxynitrite, the largest oligomer mass fractions (up to 50%) were found for equimolar concentrations of peroxynitrite over tyrosine residues. With excess peroxynitrite, the nitration degrees increased up to 40% whereas the oligomer mass fractions decreased to 20%. Our results suggest that protein oligomerization and nitration are competing processes, which is consistent with a two-step mechanism involving a reactive oxygen intermediate (ROI), as observed for other proteins. The modified proteins can promote pro-inflammatory cellular signaling that may contribute to chronic inflammation and allergies in response to air pollution.
Effect of Argon-Based Atmospheric Pressure Plasma Treatment on Hard Tissue Formation on Titanium Surface
Authors: Komasa Satoshi , Kusumoto Tetsuji , Hayashi Rina , Takao Seiji , Li Min , Yan Sifan , Zeng Yuhao , Yang Yuanyuan , Hu Hui , Kobayashi Yasuyuki , Agariguchi Akinori , Nishida Hisataka , Hashimoto Yoshiya , Okazaki Joji
Published: July 2021

In this paper, we suggest that the atmospheric pressure plasma treatment of pure titanium metal may be useful for improving the ability of rat bone marrow cells (RBMCs) to induce hard tissue differentiation. Previous studies have reported that the use of argon gas induces a higher degree of hard tissue formation. Therefore, this study compares the effects of plasma treatment with argon gas on the initial adhesion ability and hard tissue differentiation-inducing ability of RBMCs. A commercially available titanium metal plate was used as the experimental material. A plate polished using water-resistant abrasive paper #1500 was used as the control, and a plate irradiated with argon mixed with atmospheric pressure plasma was used as the experimental plate. No structural change was observed on the surface of the titanium metal plate in the scanning electron microscopy results, and no change in the surface roughness was observed via scanning probe microscopy. X-ray photoelectron spectroscopy showed a decrease in the carbon peak and the formation of hydroxide in the experimental group. In the distilled water drop test, a significant decrease in the contact angle was observed for the experimental group, and the results indicated superhydrophilicity. Furthermore, the bovine serum albumin adsorption, initial adhesion of RBMCs, alkaline phosphatase activity, calcium deposition, and genetic marker expression of rat bone marrow cells were higher in the experimental group than those in the control group at all time points. Rat distal femur model are used as in vivo model. Additionally, microcomputed tomography analysis showed significantly higher results for the experimental group, indicating a large amount of the formed hard tissue. Histopathological evaluation also confirmed the presence of a prominent newly formed bone seen in the images of the experimental group. These results indicate that the atmospheric pressure plasma treatment with argon gas imparts superhydrophilicity, without changing the properties of the pure titanium plate surface. It was also clarified that it affects the initial adhesion of bone marrow cells and the induction of hard tissue differentiation.
Toward the Specificity of Bare Nanomaterial Surfaces for Protein Corona Formation
Authors: Vianello Fabio , Cecconello Alessandro , Magro Massimiliano
Published: July 2021

Aiming at creating smart nanomaterials for biomedical applications, nanotechnology aspires to develop a new generation of nanomaterials with the ability to recognize different biological components in a complex environment. It is common opinion that nanomaterials must be coated with organic or inorganic layers as a mandatory prerequisite for applications in biological systems. Thus, it is the nanomaterial surface coating that predominantly controls the nanomaterial fate in the biological environment. In the last decades, interdisciplinary studies involving not only life sciences, but all branches of scientific research, provided hints for obtaining uncoated inorganic materials able to interact with biological systems with high complexity and selectivity. Herein, the fragmentary literature on the interactions between bare abiotic materials and biological components is reviewed. Moreover, the most relevant examples of selective binding and the conceptualization of the general principles behind recognition mechanisms were provided. Nanoparticle features, such as crystalline facets, density and distribution of surface chemical groups, and surface roughness and topography were encompassed for deepening the comprehension of the general concept of recognition patterns.
Parkinson’s Disease-Related Genes and Lipid Alteration
Authors: Fais Milena , Dore Antonio , Galioto Manuela , Galleri Grazia , Crosio Claudia , Iaccarino Ciro
Published: July 2021

Parkinson’s disease (PD) is a complex and progressive neurodegenerative disorder with a prevalence of approximately 0.5–1% among those aged 65–70 years. Although most of its clinical manifestations are due to a loss of dopaminergic neurons, the PD etiology is largely unknown. PD is caused by a combination of genetic and environmental factors, and the exact interplay between genes and the environment is still debated. Several biological processes have been implicated in PD, including mitochondrial or lysosomal dysfunctions, alteration in protein clearance, and neuroinflammation, but a common molecular mechanism connecting the different cellular alterations remains incompletely understood. Accumulating evidence underlines a significant role of lipids in the pathological pathways leading to PD. Beside the well-described lipid alteration in idiopathic PD, this review summarizes the several lipid alterations observed in experimental models expressing PD-related genes and suggests a possible scenario in relationship to the molecular mechanisms of neuronal toxicity. PD could be considered a lipid-induced proteinopathy, where alteration in lipid composition or metabolism could induce protein alteration—for instance, alpha-synuclein accumulation—and finally neuronal death.
Consumer Identity and Loyalty in Electronic Product Offline Brand Operation: The Moderator Effect of Fanship
Authors: Chen Yitao , Wang Haijian , Wang Lei , Ding Jianyi
Published: July 2021

Continuous enhancements of the intelligence of electronic products can lead to the homogenization of products and innovation of offline experiential marketing modes. The diversified development of brand sales channels is inevitable, to fulfill the diversified shopping demands of consumers. Based on 226 valid questionnaires, this study conducts empirical research with SPSS and AMOS to examine the impact of experience characteristics on consumer brand identity and brand loyalty. Then, the fanship consumer attribute is added to conduct path-moderating analysis. The results illustrated the following: (a) consumers act and relate experiences, which affects brand cognitive identity; thinking, acting, and relating experiences positively affect brands’ emotional identity; (b) cognitive identity and emotional identity can jointly create brand loyalty, and play a partial mediating role between offline experience and brand loyalty. Finally, the higher the fanship, the higher the consumer identity and the higher the brand loyalty. Overall, this study provides a certain basis for decision-making and suggestions for the offline operation of electronic brands.
Impact of Temperature on the Immune Interaction between a Parasitoid Wasp and Drosophila Host Species
Authors: Cavigliasso Fanny , Gatti Jean-Luc , Colinet Dominique , Poirié Marylène
Published: July 2021

Temperature is particularly important for ectotherms, including endoparasitoid wasps that develop inside another ectotherm host. In this study, we tested the impact of three temperatures (20 °C, 25 °C and 30 °C) on the host–parasitoid immune interaction using two Drosophila host species (Drosophila melanogaster and D. yakuba) and two parasitoid lines of Leptopilina boulardi. Drosophila’s immune defense against parasitoids consists of the formation of a melanized capsule surrounding the parasitoid egg. To counteract this response, Leptopilina parasitoids rely on the injection of venom during oviposition. Here, we tested the effect of temperature on parasitic success and host encapsulation capacity in response to a parasitoid egg or other foreign body. Increased temperature either promoted or did not affect the parasitic success, depending on the parasitoid–host pairs considered. The mechanisms behind the higher success seemed to vary depending on whether the temperature primarily affected the host immune response or also affected the parasitoid counter-immune response. Next, we tested the effect of parasitoid rearing temperature on its success and venom composition. Venom composition varied strongly with temperature for both parasitoid lines, partially consistent with a change in their parasitic success. Overall, temperature may have a significant impact on the host–parasitoid immune interaction.
Cytochrome P450s Are Essential for Insecticide Tolerance in the Endoparasitoid Wasp Meteorus pulchricornis (Hymenoptera: Braconidae)
Authors: Xing Xiaorong , Yan Mengwen , Pang Huilin , Wu Fu’an , Wang Jun , Sheng Sheng
Published: July 2021

With the widespread application of insecticides, parasitoid wasps may also be under risk when exposed to insecticides directly at their free-living stages. The endoparasitoid wasp Meteorus pulchricornis is the predominant natural enemy of many lepidopteran pests, such as Spodoptera litura and Helicoverpa armigera. The cytochrome P450 monooxygenases constitute a ubiquitous and complex superfamily of hydrophobic, haem-containing enzymes. P450s are involved in the detoxification of many xenobiotics. However, their exact roles in the tolerance mechanism in parasitoids toward insecticides has received less attention. Here, 28 P450 genes in M. pulchricornis were identified from a previously constructed transcriptome dataset. These P450 genes belonged to CYP2, -3, and -4, and mitochondrial clans. Subsequently, eight candidate MpulCYPs were selected from four CYP clans to validate their expression patterns under phoxim, cypermethrin, and chlorfenapyr exposure by qRT-PCR. The results showed that all three insecticides had significant effects on the expression of MpulCYPs. To further study the function of P450s, CYP369B3 was silenced, and its expression levels of CYP369B3 were significantly decreased. Survival analysis indicated that after dsRNA injection, the mortality rate of wasps was significantly increased when M. pulchricornis females were exposed to insecticides compared to control groups. Our findings provide a theoretical base for elucidating the mechanism of insecticide tolerance and promote functional research on P450 genes in parasitoid wasps.
RP11-362K2.2:RP11-767I20.1 Genetic Variation Is Associated with Post-Reperfusion Therapy Parenchymal Hematoma. A GWAS Meta-Analysis
Authors: Muiño Elena , Cárcel-Márquez Jara , Carrera Caty , Llucià-Carol Laia , Gallego-Fabrega Cristina , Cullell Natalia , Lledós Miquel , Castillo José , Sobrino Tomás , Campos Francisco , Rodríguez-Castro Emilio , Millán Mònica , Muñoz-Narbona Lucía , Bustamante Alejandro , López-Cancio Elena , Ribó Marc , Álvarez-Sabín José , Jiménez-Conde Jordi , Roquer Jaume , Giralt-Steinhauer Eva , Soriano-Tárraga Carolina , Vives-Bauza Cristófol , Díaz-Navarro Rosa , Tur Silvia , Obach Victor , Arenillas Juan , Segura Tomás , Serrano-Heras Gemma , Martí-Fàbregas Joan , Delgado-Mederos Raquel , Camps-Renom Pol , Prats-Sánchez Luis , Guisado Daniel , Guasch Marina , Marin Rebeca , Martínez-Domeño Alejandro , Freijo-Guerrero Maria , Moniche Francisco , Cabezas Juan , Castellanos Mar , Krupinsky Jerzy , Strbian Daniel , Tatlisumak Turgut , Thijs Vincent , Lemmens Robin , Slowik Agnieszka , Pera Joanna , Heitsch Laura , Ibañez Laura , Cruchaga Carlos , Dhar Rajat , Lee Jin-Moo , Montaner Joan , Fernández-Cadenas Israel , Consortium on , Consortium the
Published: July 2021

Stroke is one of the most common causes of death and disability. Reperfusion therapies are the only treatment available during the acute phase of stroke. Due to recent clinical trials, these therapies may increase their frequency of use by extending the time-window administration, which may lead to an increase in complications such as hemorrhagic transformation, with parenchymal hematoma (PH) being the more severe subtype, associated with higher mortality and disability rates. Our aim was to find genetic risk factors associated with PH, as that could provide molecular targets/pathways for their prevention/treatment and study its genetic correlations to find traits sharing genetic background. We performed a GWAS and meta-analysis, following standard quality controls and association analysis (fastGWAS), adjusting age, NIHSS, and principal components. FUMA was used to annotate, prioritize, visualize, and interpret the meta-analysis results. The total number of patients in the meta-analysis was 2034 (216 cases and 1818 controls). We found rs79770152 having a genome-wide significant association (beta 0.09, p-value 3.90 × 10−8) located in the RP11-362K2.2:RP11-767I20.1 gene and a suggestive variant (rs13297983: beta 0.07, p-value 6.10 × 10−8) located in PCSK5 associated with PH occurrence. The genetic correlation showed a shared genetic background of PH with Alzheimer’s disease and white matter hyperintensities. In addition, genes containing the ten most significant associations have been related to aggregated amyloid-β, tau protein, white matter microstructure, inflammation, and matrix metalloproteinases.
Optimization of Laser Engraving of Acrylic Plastics from the Perspective of Energy Consumption, CO2 Emission and Removal Rate
Authors: Khan Mohammad Muhshin Aziz , Saha Shanta , Romoli Luca , Kibria Mehedi Hasan
Published: July 2021

This paper focuses on optimizing the laser engraving of acrylic plastics to reduce energy consumption and CO2 gas emissions, without hindering the production and material removal rates. In this context, the role of laser engraving parameters on energy consumption, CO2 gas emissions, production rate, and material removal rate was first experimentally investigated. Grey–Taguchi approach was then used to identify an optimal set of process parameters meeting the goal. The scan gap was the most significant factor affecting energy consumption, CO2 gas emissions, and production rate, whereas, compared to other factors, its impact on material removal rate (MRR) was relatively lower. Moreover, the defocal length had a negligible impact on the response variables taken into consideration. With this laser-process-material combination, to achieve the desired goal, the laser must be focused on the surface, and laser power, scanning speed, and scan gap must be set at 44 W, 300 mm/s, and 0.065 mm, respectively.
Predictive Biomarkers of Oxaliplatin-Induced Peripheral Neurotoxicity
Authors: Velasco Roser , Alemany Montserrat , Villagrán Macarena , Argyriou Andreas A.
Published: July 2021

Oxaliplatin (OXA) is a platinum compound primarily used in the treatment of gastrointestinal cancer. OXA-induced peripheral neurotoxicity (OXAIPN) is the major non-hematological dose-limiting toxicity of OXA-based chemotherapy and includes acute transient neurotoxic effects that appear soon after OXA infusion, and chronic non-length dependent sensory neuronopathy symmetrically affecting both upper and lower limbs in a stocking-and-glove distribution. No effective strategy has been established to reverse or treat OXAIPN. Thus, it is necessary to early predict the occurrence of OXAIPN during treatment and possibly modify the OXA-based regimen in patients at high risk as an early diagnosis and intervention may slow down neuropathy progression. However, identifying which patients are more likely to develop OXAIPN is clinically challenging. Several objective and measurable early biomarkers for OXAIPN prediction have been described in recent years, becoming useful for informing clinical decisions about treatment. The purpose of this review is to critically review data on currently available or promising predictors of OXAIPN. Neurological monitoring, according to predictive factors for increased risk of OXAIPN, would allow clinicians to personalize treatment, by monitoring at-risk patients more closely and guide clinicians towards better counseling of patients about neurotoxicity effects of OXA.
Neuroimmunology and (Epi)Genetics in Depressive Disorders
Authors: Gałecki Piotr , Bliźniewska-Kowalska Katarzyna , Maes Michael , Su Kuan-Pin
Published: July 2021

Depression causes individual suffering, loss of productivity, increased health care costs and high suicide risk [...]
Remote Sensing Monitoring and Evaluation of Vegetation Restoration in Grassland Mining Areas—A Case Study of the Shengli Mining Area in Xilinhot City, China
Authors: Hui Jiawei , Bai Zhongke , Ye Baoying , Wang Zihao
Published: July 2021

Coal production will cause serious damage to regional vegetation, especially in ecologically fragile grasslands. It is the consensus of all major countries to conduct vegetation restoration and management monitoring in areas damaged by coal production. This paper compares the adaptability of different data sources and different vegetation indices to grassland mining areas and proposes a normalized environmental vegetation index (NEVI) suitable for vegetation monitoring in grassland mining areas. Based on the Landsat and Sentinel data from 2005 to 2019, this paper uses NEVI to monitor the vegetation destruction and restoration of the Shengli mining area. The main result is that the vegetation restoration work in the Shengli mining area started in 2007 and was gradually carried out in subsequent years. The restoration effect of vegetation is significantly better in the east than in the west. The NEVI of the vegetation in the east can reach, or exceed, the level of natural vegetation in the same period. The restoration of vegetation degradation in some areas requires strengthening of management and maintenance measures.
Phase Stability of Iron Nitride Fe4N at High Pressure—Pressure-Dependent Evolution of Phase Equilibria in the Fe–N System
Authors: Wetzel Marius Holger , Rabending Tina Trixy , Friák Martin , Všianská Monika , Šob Mojmír , Leineweber Andreas
Published: July 2021

Although the general instability of the iron nitride γ′-Fe4N with respect to other phases at high pressure is well established, the actual type of phase transitions and equilibrium conditions of their occurrence are, as of yet, poorly investigated. In the present study, samples of γ′-Fe4N and mixtures of α Fe and γ′-Fe4N powders have been heat-treated at temperatures between 250 and 1000 °C and pressures between 2 and 8 GPa in a multi-anvil press, in order to investigate phase equilibria involving the γ′ phase. Samples heat-treated at high-pressure conditions, were quenched, subsequently decompressed, and then analysed ex situ. Microstructure analysis is used to derive implications on the phase transformations during the heat treatments. Further, it is confirmed that the Fe–N phases in the target composition range are quenchable. Thus, phase proportions and chemical composition of the phases, determined from ex situ X-ray diffraction data, allowed conclusions about the phase equilibria at high-pressure conditions. Further, evidence for the low-temperature eutectoid decomposition γ′→α+ε′ is presented for the first time. From the observed equilibria, a P–T projection of the univariant equilibria in the Fe-rich portion of the Fe–N system is derived, which features a quadruple point at 5 GPa and 375 °C, above which γ′-Fe4N is thermodynamically unstable. The experimental work is supplemented by ab initio calculations in order to discuss the relative phase stability and energy landscape in the Fe–N system, from the ground state to conditions accessible in the multi-anvil experiments. It is concluded that γ′-Fe4N, which is unstable with respect to other phases at 0 K (at any pressure), has to be entropically stabilised in order to occur as stable phase in the system. In view of the frequently reported metastable retention of the γ′ phase during room temperature compression experiments, energetic and kinetic aspects of the polymorphic transition γ′⇌ε′ are discussed.
The Influence of the Cooling Bores on the Dendritic Structure and Crystal Orientation in Single-Crystalline Cored CMSX-4 Turbine Blades
Authors: Krawczyk Jacek , Bogdanowicz Włodzimierz
Published: July 2021

Single-crystalline cored CMSX-4 blades obtained at a withdrawal rate of 3 mm/min by the vertical Bridgman method were analyzed. The dendritic structure and crystal orientation near the cooling bores of the blades were studied through Scanning Electron Microscopy, the X-ray diffraction measurements of α and β angular components of the primary crystal orientation, and the γ angular component of the secondary crystal orientation. Additionally, the primary arm spacing (PAS) was studied in areas near and far from the cooling bores. It was found that in the area approximately 3–4 mm wide around the cooling bores, changes occurred in the α, β, and γ angles, as well as in the PAS. The PAS determined for the transverse section of the root and the linear primary arm spacing (LPAS) determined for the longitudinal sections, as well as their relationship, have been defined for the areas located near the cooling bores and those at a distance from them. The vertical temperature gradient of 29.5 K/cm was estimated in the root areas located near the cooling bores based on the PAS values. The value of this gradient was significantly higher compared to the growth chamber operating gradient of 16 K/cm. The two-scale analysis applied in this study allowed for the determination of the relationship between the process of dendrite array creation proceeding on a millimeter scale, which is associated with the local changes in crystal orientation near the cooling bores, and that which proceeds on a scale of tens of millimeters, associated with the changes in crystal orientation in the whole blade cast.
A New Approach for Fatigue Reliability Analysis of Thin-Walled Structures with DC-ILSSVR
Authors: Du Wenyi , Ma Juan , Dai Changping , Yue Peng , Zu Jean W.
Published: July 2021

Fatigue analysis is of great significance for thin-walled structures in the spacecraft industry to ensure their service reliability during operation. Due to the complex loadings of thin-walled structures under thermal–structural–acoustic coupling conditions, the calculation cost of finite element (FE) simulations is relatively expensive. To improve the computational efficiency of dynamic reliability analysis on thin-walled structures to within acceptable accuracy, a novel probabilistic approach named DC-ILSSVR was developed, in which the rotation matrix optimization (RMO) method was used to initially search for the model parameters of least squares support vector regression (LS-SVR). The distributed collaborative (DC) strategy was then introduced to enhance the efficiency of a component suffering from multiple failure modes. Moreover, a numerical example with respect to thin-walled structures was used to validate the proposed method. The results showed that RMO performed on LS-SVR model parameters provided competitive prediction accuracy, and hence the reliability analysis efficiency of thin-walled pipe was significantly improved.
Investigation of Damage Evolution in Heterogeneous Rock Based on the Grain-Based Finite-Discrete Element Model
Authors: Zhang Shirui , Qiu Shili , Kou Pengfei , Li Shaojun , Li Ping , Yan Siquan
Published: July 2021

Granite exhibits obvious meso-geometric heterogeneity. To study the influence of grain size and preferred grain orientation on the damage evolution and mechanical properties of granite, as well as to reveal the inner link between grain size‚ preferred orientation, uniaxial tensile strength (UTS) and damage evolution, a series of Brazilian splitting tests were carried out based on the combined finite-discrete element method (FDEM), grain-based model (GBM) and inverse Monte Carlo (IMC) algorithm. The main conclusions are as follows: (1) Mineral grain significantly influences the crack propagation paths, and the GBM can capture the location of fracture section more accurately than the conventional model. (2) Shear cracks occur near the loading area, while tensile and tensile-shear mixed cracks occur far from the loading area. The applied stress must overcome the tensile strength of the grain interface contacts. (3) The UTS and the ratio of the number of intergrain tensile cracks to the number of intragrain tensile cracks are negatively related to the grain size. (4) With the increase of the preferred grain orientation, the UTS presents a “V-shaped” characteristic distribution. (5) During the whole process of splitting simulation, shear microcracks play the dominant role in energy release; particularly, they occur in later stage. This novel framework, which can reveal the control mechanism of brittle rock heterogeneity on continuous-discontinuous trans-scale fracture process and microscopic rock behaviour, provides an effective technology and numerical analysis method for characterizing rock meso-structure. Accordingly, the research results can provide a useful reference for the prediction of heterogeneous rock mechanical properties and the stability control of engineering rock masses.
Study of Friction and Wear Effects in Aluminum Parts Manufactured via Single Point Incremental Forming Process Using Petroleum and Vegetable Oil-Based Lubricants
Authors: Zavala José M. Diabb , Martínez-Romero Oscar , Elías-Zúñiga Alex , Gutiérrez Héctor Manuel Leija , Vega Alejandro Estrada-de la , Taha-Tijerina Jaime
Published: July 2021

This paper focuses on studying how mineral oil, sunflower, soybean, and corn lubricants influence friction and wear effects during the manufacturing of aluminum parts via the single point incremental forming (SPIF) process. To identify how friction, surface roughness, and wear change during the SPIF of aluminum parts, Stribeck curves were plotted as a function of the SPIF process parameters such as vertical step size, wall angle, and tool tip semi-spherical diameter. Furthermore, lubricant effects on the surface of the formed parts are examined by energy dispersive spectroscopy (EDS) and scanning electron microscope (SEM) images, the Alicona optical 3D measurement system, and Fourier-transform infrared spectroscopy (FTIR). Results show that during the SPIF process of the metallic specimens, soybean and corn oils attained the highest friction, along forces, roughness, and wear values. Based on the surface roughness measurements, it can be observed that soybean oil produces the worst surface roughness finish in the direction perpendicular to the tool passes (Ra =1.45 μm) considering a vertical step size of 0.25 mm with a 5 mm tool tip diameter. These findings are confirmed through plotting SPIFed Stribeck curves for the soybean and corn oils that show small hydrodynamic span regime changes for an increasing sample step-size forming process. This article elucidates the effects caused by mineral and vegetable oils on the surface of aluminum parts produced as a function of Single Point Incremental Sheet Forming process parameters.
Bounding the Multi-Scale Domain in Numerical Modelling and Meta-Heuristics Optimization: Application to Poroelastic Media with Damageable Cracks
Authors: Argilaga Albert , Papachristos Efthymios
Published: July 2021

It is very common for natural or synthetic materials to be characterized by a periodic or quasi-periodic micro-structure. This micro-structure, under the different loading conditions may play an important role on the apparent, macroscopic behaviour of the material. Although, fine, detailed information can be implemented at the micro-structure level, it still remains a challenging task to obtain experimental metrics at this scale. In this work, a constitutive law obtained by the asymptotic homogenization of a cracked, damageable, poroelastic medium is first evaluated for multi-scale use. For a given range of micro-scale parameters, due to the complex mechanical behaviour at micro-scale, such multi-scale approaches are needed to describe the (macro) material’s behaviour. To overcome possible limitations regarding input data, meta-heuristics are used to calibrate the micro-scale parameters targeted on a synthetic failure envelope. Results show the validity of the approach to model micro-fractured materials such as coal or crystalline rocks.
Numerical Simulation of Non-Uniformly Distributed Corrosion in Reinforced Concrete Cross-Section
Authors: German Magdalena , Pamin Jerzy
Published: July 2021

Reinforced concrete structures can be strongly damaged by chloride corrosion of reinforcement. Rust accumulated around rebars involves a volumetric expansion, causing cracking of the surrounding concrete. To simulate the corrosion progress, the initiation phase of the corrosion process is first examined, taking into account the phenomena of oxygen and chloride transport as well as the corrosion current flow. This makes it possible to estimate the mass of produced rust, whereby a corrosion level is defined. A combination of three numerical methods is used to solve the coupled problem. The example object of the research is a beam cross-section with four reinforcement bars. The proposed methodology allows one to predict evolving chloride concentration and time to reinforcement depassivation, depending on the reinforcement position and on the location of a point on the bar surface. Moreover, the dependence of the corrosion initiation time on the chloride diffusion coefficient, chloride threshold, and reinforcement cover thickness is examined.
Evaluation of Wear Behaviour in Metallic Binders Employed in Diamond Tools for Cutting Stone
Authors: Ternero Fátima , Amaral Pedro M. , Fernandes Jorge Cruz , Rosa Luís Guerra
Published: July 2021

A type of disc-on-plate test methodology was used to determine the wear behavior of metallic binders employed in the manufacturing of diamond impregnated tools. The disc consists of a special circular wheel that allows the binder materials alone (i.e., without diamond, but sintered under conditions identical to those of the complete tool) to be tested against a plate of stone material under pre-determined testing conditions. The testing conditions are intended to be equivalent to those used in the industrial processes. Using plates of five types of granite and one type of marble, this work comprises wear tests of 15 different types of metallic binders and two sintering modes conducted under, at least, three different values of contact-force. The analysis of the results demonstrated that the wear of the binders can be related to their mechanical properties through an empirical expression. The larger the difference between the characteristics of the tribological pair (binder versus stone), the higher is the correlation between the experimental wear data and the values given by the empirical expression. The relationships presented in this work allow predicting the wear behavior of the binder, and therefore may help in the design process of diamond tools. There was a clear difference between the wear behavior of metallic binders when they were employed against the two main classes of stone under analysis (marble and granite).
Effect of Feldspar Substitution by Basalt on Pyroplastic Behaviour of Porcelain Tile Composition
Authors: Locks Mateus , Arcaro Sabrina , Bergmann Carlos P. , Ribeiro Manuel J. , Raupp-Pereira Fabiano , Montedo Oscar R. K.
Published: July 2021

This work aims to evaluate the effects of feldspar substitution by basalt on porcelain tile composition with respect to its porosity, flexural strength, and pyroplastic deformation. Three ceramic formulations with different amounts of feldspar substituted with basalt, 50% (C1), 75% (C2), and 100% (C3), were evaluated at three different temperatures, 1200, 1220, and 1240 °C. Specifically, the effect of replacing feldspar with basalt on the pyroplastic deformation of ceramic bodies was analysed using optical fleximetry. The porosity of C1 at 1200 °C was 19.3 ± 2.9%, while that of composition C3 was 22.2 ± 0.7% at 1240 °C. The flexural strength was strongly influenced by the temperature. For C1 at 1200 and 1240 °C, flexural strengths of 11.1 ± 0.6 and 22.2 ± 1.9 MPa, respectively, were obtained. Regarding fleximetry, thermal deformation decreased with an increase in the amount of feldspar substituted with basalt. It was observed that C2 and C3 deformed less at high temperatures than the other combinations of compositions and temperature, probably owing to the lower amount of residual glass phase present during cooling. Compositions with higher substitution amounts of basalt (i.e., C2 and C3) exhibited more stable thermal behaviour than C0.