bluuebunny/crossref_metadata_2025 huggingface dataset:
ROLES OF ENGOS IN NITRATE CONFLICT MANAGEMENT: CASE STUDY: THE NETHERLANDS AND FLANDERS, BELGIUM
Authors: Sulistiawati Linda Yanti
Published: August 2023

In developed countries, conflicts between environmental interests and agricultural emissions can not be avoided. Within the legal formal perspective, it is often assumed that all environmental conflicts are solved through the legal-formal system. In reality, however, the conflict between environmental concern and agricultural practices is complicated by wide variety of interests and mere legal formal approaches will not be adequate to solve them. This conflict as it relates to nitrate emissions will be referred to herein as the ‘nitrate conflict’. The role of civil society, in this case the Environmental Non-Governmental Organizations (ENGOs), are often neglected in the nitrate conflict management. This study will document and analyze nitrate con.ict management in the Netherlands and Flanders Belgium, on the roles of ENGOs regarding the issue. Moreover, the research will emphasize the important role of ENGOs in civic engagement in developing democratic and just environmental management.
MEDIASI SEBAGAI BASIS DALAM PENYELESAIAN PERKARA PIDANA
Authors: Raharjo Agus
Published: August 2023

Litigation model on criminal justice process can’t give satisfy and justice to offender and victim crime, so must be reform. Criminal Justice System is a network of criminal justice by using criminal law as ultimate material. The resolution of criminal cases at the time in Indonesia based on KUHAP (Act No. 8/1981) is recognized as litigation model. On KUHAP, non litigation model on criminal cases resolution is unknown, but based data research in Central Java, we are concluding that criminal cases resolution through non litigation model can be enable in Indonesia. For offender and victim, they can look for by way and place other. Non litigation model of criminal cases resolution can answer weakness on litigation model and show that existence of justice in many room; and according to pluralism in our constitutional, this model ought to accommodate in criminal justice system.
Mauren Pavão Przybylski da Hora Vidal. “Materiais Orais e Decolonialidade: uma Introdução” [curso on-line].
Authors: Pio Borges Cláudia Beatriz
Published: August 2023

"Com o advento da pandemia rondando nossas vidas, muitos se reinventaram e foram criando alternativas para continuar pesquisando, estudando e ministrando aulas. A Prof.ª Mauren Pavão Przybylski da Hora Vidal criou alternativas e no novo “normal”, o online, organizou diversos cursos. Tratarei aqui do curso “Materias Orais e Decolonialidade: uma introdução”; que foi ministrado em março de 2022, dias 12 e 19, com duração de 8 hrs. no total..."
Conceptualizing “Preparedness for Practice”: Perspectives of Early-Career Family Physicians
Authors: Aggarwal Monica , Abdelhalim Reham , Fowler Nancy , Oandasan Ivy
Published: August 2023

Background and Objectives: Competency based medical education (CBME) aims to produce graduates prepared for independent practice. Many equate the outcome of “preparedness for practice” with acquisition of competence. As educators evaluate the outcomes of CBME, being clear on the concept of preparedness for practice will clarify the results that are measured and assessed. This study examined how preparedness for practice is conceptualized in the literature and by family physicians (FPs) in Canada.
Methods: This multimethod qualitative descriptive study included (1) rapid review and narrative synthesis, and (2) focus groups with early-career FPs using maximum variation sampling until thematic saturation was reached. Focus groups explored the FPs’ conceptualizations of preparedness for practice. Focus groups were audio-recorded, transcribed, and coded before content analysis.
Results: Thirty-four articles met the inclusion criteria, and 59 early-career FPs participated in the focus groups. We found no consensus on the conceptualization of preparedness for practice in the literature; however, the concept often was described as acquiring competencies for program requirements. In the literature and focus groups, we identified four themes for the conceptualization of preparedness for practice. These themes included competence, self-confidence (self-efficacy, self-concept), capability, and adaptability.
Conclusions: Preparedness for practice involves an interplay of dynamic and complex constructs from competence, self-confidence, capability, and adaptability. Preparedness is more than possessing several competencies; it calls for integrating and applying competencies in complex and changing environments. This study aimed to start a discussion on what end point is desirable for residency education and proposed that the end point needs to move beyond competencies.
Italia Minore si Svela: conservazione e innovazione per rivitalizzare i borghi
Authors: Landi Anna
Published: August 2023

Italia Minore si Svela, nasce per sensibilizzare principalmente i
giovani e la collettività, alla cultura per la tutela e riconoscimento
del bene comune. Promuovendo iniziative per la gestione, conservazione e
fruizione delle meravigliose ricchezze dei piccoli territori. Non solo
per il recupero del patrimonio e delle infrastrutture, ma della
vocazione specifica dei luoghi, su cui costruire un’azione di
ripopolamento che sia duratura e sostenibile. Ho posto l’attenzione
sulle problematiche relative allo spopolamento, segnalando le cause che
mettono a rischio il patrimonio dei piccoli comuni e promuovendo
comportamenti virtuosi, multidisciplinari, che nel tempo sono risultati
efficaci nell’azione di tutela, gestione e valorizzazione dei beni
culturali minori. Un’ opportunità per valorizzare le attività esistenti
e attivarne di nuove. L’esperienza del lockdown, causa pandemia
Covid-19, ha agevolato l’utilizzo tecnologico di connessione e
comunicazione (smart working e DAD), favorendo la ripopolazione di
borghi semi-abbandonati. Partendo dai piccoli centri immersi nel verde
del Parco Nazionale del Cilento, Vallo di Diano e Alburni, ho avviato
una catalogazione nazionale dei piccoli comuni caratterizzati da intatte
identità e peculiarità. Il valore aggiunto nel processo catalogativo
risiede nel ruolo attivo assegnato al fruitore, che potrà segnalare un
sito contribuendo all’arricchimento del materiale raccolto. La
condivisione pubblica consente di divulgare conoscenze utili che
rimarranno a disposizione della collettività. Le schede descrittive dei
luoghi, realizzate, possono essere utilizzate anche mediante
applicazione di tecnologie digitali. Conoscere è il primo passo per
svelare realtà di un’Italia minore, ma dal grande fascino.
Title: In-silico study of fatty acid biosynthesis pathway enzymes in microalga Scenedesmus
Authors: Sharma Harshit Kumar , Velázquez Ma Belén , Marchetti Noelia , Busi Ma Victoria , Barchiesi Julieta , Dasgupta Chitralekha Nag
Published: August 2023

Scenedesmus is an important, rapidly growing, freshwater microalga
because of its significantly high lipid content. However, the molecular
basis of fatty acid biosynthesis is scarcely elucidated not only in
Scenedesmus but also in microalgae as a whole. Mining the genome of
Scenedesmus, we identified some of the crucial enzymes involved in fatty
acid biosynthesis pathways such as acetyl-CoA carboxylase (ACC),
malonyl-CoA:ACP transacylase (MAT) and fatty-acyl thioesterases (FAT).
Detailed comparative analyses of  these identified enzymes demonstrated
highly significant sequence similarity with homologs of bacteria
suggesting an evolutionary linkage. Moreover, the molecular modeling and
3D structures of the chloroplastic enzymes revealed that the overall
structural orientation and the catalytic residues are well conserved. On
the other hand, biotin protein ligase and cytosolic acetyl-CoA
carboxylase isoforms presented some significant differences with respect
the previously reported protein models. Our analysis describes some
specific features in Scenedesmus fatty acid synthesis enzymes that could
be responsible for their particular lipid accumulation profile.
Unequivocal principles for area-based biodiversity conservation
Authors: Riva Federico , Haddad Nick , Fahrig Lenore , Banks-Leite Cristina
Published: August 2023

Recent agreements have strengthened and expanded ongoing international
commitments to protect and restore native habitats. Nevertheless, how
such commitments should be implemented has been historically
controversial, and nuances in ongoing debates are often misunderstood,
hindering biodiversity conservation. We propose three unequivocal
principles that must be central to how area-based biodiversity
conservation will occur in the coming decades. These principles relate
to habitat coverage, amount, and connectivity, and their enunciation
clarifies apparent contradictions in the literature. We explain why
socio-economic considerations that are central to current biodiversity
conservation cannot override these principles. Biodiversity must be
supported everywhere on Earth, especially when considering the right of
human population to access nature and to benefit from countless
ecosystem services.
Mechanistic Modeling of In Vitro Transcription
Authors: Braatz Richard , Stover Nathan Merica , Ganko Krystian
Published: August 2023

The in vitro transcription (IVT) reaction used in the production of mRNA
vaccines and therapies remains poorly quantitatively understood.
Mechanistic modeling of IVT could inform reaction design, scale up,
optimization, and control. In this work, we develop a mechanistic model
of IVT to include nucleation and growth of magnesium pyrophosphate
crystals and subsequent agglomeration of crystals and DNA. A novel
quantitative description is included for the rate of transcription as a
function of target sequence length, DNA concentration, and T7 polymerase
concentration. The model explains previously unexplained trends in IVT
data and quantitatively predicts the effect of adding the
pyrophosphatase enzyme to the reaction system. The model is validated on
additional literature data showing an ability to predict transcription
rates as a function of RNA sequence length.
A Guide for Accounting Researchers to Conduct and Report Systematic Literature Reviews
Authors: Hardies Kris , Ohlrogge Fynn , Mentens Jo , Vandennieuwenhuysen Jonas
Published: August 2023

Literature reviews can potentially contribute to our knowledge and understanding of a particular topic. However, consistent with anecdotal evidence, we document that literature reviews in auditing are of low quality in implementing best practice guidelines for conducting and reporting systematic reviews. We rely on existing guidelines and best practices in other domains to offer accounting researchers a step-by-step guide for conducting and reporting systematic literature reviews. We hope this guide will help to improve the quality of literature reviews in accounting and the assessment of such reviews by editors and reviewers.
Should Companies Use the Same Provider for Financial Statement Audit and Assurance of Extended External Reports?
Authors: Lu Meiting , Simnett Roger , Zhou Shan
Published: August 2023

Companies are increasingly reporting and assuring sustainability information. Once the decision to assure is made, a company must choose an assurance provider, but should the company use the same firm as its financial statement auditor or a different assurance provider? Lu, Simnett, and Zhou (2023) find that perceived independence concerns deter companies from choosing the same provider, while a provider’s assurance expertise and higher levels of information integration between the financial statements and the extended external report both increase the likelihood of using the same provider. Companies using the same provider for both services benefit from higher financial statement audit quality without paying significantly higher audit fees. The findings of this research are useful for companies in deciding whether to employ their financial statement audit firm to also provide assurance of extended external reports. The findings also have implications for auditors and standard-setters/regulators.
What Can Bayesian Inference Do for Accounting Research?
Authors: Schütt Harm H.
Published: August 2023

Bayesian statistics is a framework for combining new data with existing forms of information to yield more precise inferences than are possible using the data alone. Its greatest practical advantages are the flexibility it offers in incorporating prior information and beliefs, modeling heterogeneity, modeling latent constructs, and combining multiple data sources. There are two goals of this paper: to introduce accounting researchers to Bayesian inference and distinguish it from classical frequentist inference and to showcase when Bayesian modeling can improve inferences in many applications that are of interest to accounting researchers.

Data Availability: Data are available from the public sources described in the text.

JEL Classifications: C11; C53; G17; M40.
Wearing out the Watchdog: The Impact of SEC Case Backlog on the Formal Investigation Process
Authors: Bonsall Samuel B. , Holzman Eric R. , Miller Brian P.
Published: August 2023

We examine a comprehensive set of investigations by the SEC’s Division of Enforcement offices to provide evidence on the consequences of these office’s busyness on the formal investigation process. We find that higher office case backlog decreases the likelihood of an investigation into a restating firm. Our results show no evidence that higher backlogs affect the SEC’s ability to pursue cases involving revenue recognition issues and high insider trading, which is consistent with the agency’s stated priorities. But our findings indicate that busy SEC offices are less likely to pursue cases with the largest shareholder losses, which is inconsistent with SEC priorities. Backlog also impacts pursued investigations, leading to more prolonged investigations, a lower Accounting and Auditing Enforcement Releases likelihood, and smaller SEC penalties. Our evidence suggests that busyness undermines the SEC’s investigation process.

JEL Classifications: G18; G38; K42; M41.
Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability
Authors: Thirawatananond Puchong , Brown Matthew E. , Sachs Lindsey K. , Arnoletti Juan M. , Yeh Wen-I , Posgai Amanda L. , Shapiro Melanie R. , Chen Yi-Guang , Brusko Todd M.
Published: August 2023

Costimulation serves as a critical checkpoint for T-cell activation, and several genetic variants affecting costimulatory pathways confer risk for autoimmune diseases. A single nucleotide polymorphism (rs763361) in the CD226 gene encoding a costimulatory receptor increases susceptibility to multiple autoimmune diseases, including type 1 diabetes. We previously found that Cd226 knockout protected NOD mice from disease, but the impact of CD226 on individual immune subsets remained unclear. Our prior reports implicate regulatory T cells (Tregs), as human CD226+ Tregs exhibit reduced suppressive function. Hence, we hypothesized that genomic Cd226 gene deletion would increase Treg stability and that Treg-specific Cd226 deletion would inhibit diabetes in NOD mice. Indeed, crossing NOD.Cd226−/− and a NOD Treg-lineage tracing strain resulted in decreased pancreatic Foxp3-deficient “ex-Tregs.” We generated a novel Treg-conditional knockout (TregΔCd226) strain that displayed decreased insulitis and diabetes incidence. CD226-deficient pancreatic Tregs had increased expression of the coinhibitory counter-receptor T-cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT). Moreover, NOD splenocytes treated with TIGIT-Fc fusion protein exhibited reduced T-cell proliferation and interferon-γ production following anti-CD3/CD28 stimulation. This study demonstrates that a CD226/TIGIT imbalance contributes to Treg instability in NOD mice and highlights the potential for therapeutic targeting this costimulatory pathway to halt autoimmunity.

Article Highlights
Inhibiting Phosphatidylcholine Remodeling in Adipose Tissue Increases Insulin Sensitivity
Authors: He Mulin , Li Zhiqiang , Tung Victoria Sook Keng , Pan Meixia , Han Xianlin , Evgrafov Oleg , Jiang Xian-Cheng
Published: August 2023

Cell membrane phosphatidylcholine (PC) composition is regulated by lysophosphatidylcholine acyltransferase (LPCAT); changes in membrane PC saturation are implicated in metabolic disorders. Here, we identified LPCAT3 as the major isoform of LPCAT in adipose tissue and created adipocyte-specific Lpcat3–knockout mice to study adipose tissue lipid metabolism. Transcriptome sequencing and plasma adipokine profiling were used to investigate how LPCAT3 regulates adipose tissue insulin signaling. LPCAT3 deficiency reduced polyunsaturated PCs in adipocyte plasma membranes, increasing insulin sensitivity. LPCAT3 deficiency influenced membrane lipid rafts, which activated insulin receptors and AKT in adipose tissue, and attenuated diet-induced insulin resistance. Conversely, higher LPCAT3 activity in adipose tissue from ob/ob, db/db, and high-fat diet–fed mice reduced insulin signaling. Adding polyunsaturated PCs to mature human or mouse adipocytes in vitro worsened insulin signaling. We suggest that targeting LPCAT3 in adipose tissue to manipulate membrane phospholipid saturation is a new strategy to treat insulin resistance.

Article Highlights
Impact of Intra-Articular Corticosteroid Injection on Glycemic Control: A Population-Based Cohort Study
Authors: T. Sytsma Terin , S. Greenlund Laura , M. Fischer Karen , G. McCoy Rozalina
Published: August 2023

This retrospective cohort study investigated the longer-term hyperglycemic effects of intra-articular corticosteroid (IACS) administration by evaluating changes in A1C after large joint IACS injection. Among 1,169 patients (mean age 66.1 ± 12.2 years), 52.8% female), 184 (15.7%) experienced a greater-than-expected rise in A1C (actual A1C ≥0.5% above predicted) after IACS. Greater-than-expected rise in A1C was associated solely with baseline A1C (odds ratio [OR] 1.84 (95% CI 1.08–3.13) for baseline A1C of 7.0–8.0% compared to <7.0% and OR 4.79 (95% CI 2.83–8.14) for baseline A1C >8.0% compared to <7.0%. Although most patients do not experience an increase in A1C after IACS, clinicians should counsel patients with suboptimally controlled diabetes about risks of further hyperglycemia after IACS administration.

Key Points

· The longer-term impact of intra-articular corticosteroid (IACS) on diabetes is unknown.

· A1C did not rise more than expected after large joint IACS for most patients.

· An A1C >8.0% before IACS predicted a greater-than-expected rise in A1C after IACS.
Perianal Vesiculo-pustular Eruptions in a 28-year-old Male: A Quiz
Authors: Riegler Margareta J. , Hofmann-Wellenhof Rainer , Sadoghi Birgit
Published: August 2023

Abstract is missing (Quiz)
Implementación de gamificación en ambientes virtuales de enseñanza-aprendizaje para la educación superior
Authors: Medel-San Elías Y. Lisset , Moreno Beltrán Reyna , Aguirre Caracheo Eduardo
Published: August 2023

En la educación superior, la implementación de ambientes virtuales de enseñanza-aprendizaje ha tomado un papel relevante en los últimos años. Estos espacios permiten a los estudiantes acceder a los materiales educativos desde cualquier lugar y en cualquier momento, lo que les brinda una mayor flexibilidad y autonomía en su proceso de aprendizaje. Sin embargo, aunque estos espacios son altamente eficientes, pueden resultar monótonos y poco atractivos para algunos alumnos. Es aquí donde la gamificación puede marcar una gran diferencia. Por eso, la implementación de este recurso en ambientes virtuales de enseñanza-aprendizaje en la educación superior se ha convertido en una tendencia emergente que busca mejorar la motivación, el compromiso y el rendimiento académico de los estudiantes. La presente investigación se llevó a cabo en la Facultad de Informática de la Universidad Autónoma de Querétaro mediante una metodología cuantitativa en donde se implementó un instrumento de 20 ítems en escala Likert, el cual nos permitió conocer con cifras concretas la opinión de los estudiantes con respecto a la implementación de gamificación en ambientes virtuales de enseñanza-aprendizaje, así como su percepción de alguna mejoría o aumento con respecto a su aprendizaje, motivación o interés en las materias, cursos, actividades o temas. En definitiva, la gamificación puede ser una técnica efectiva para mejorar la motivación y el aprendizaje. Sin embargo, para obtener sus beneficios, es importante diseñar las actividades, temas o materias cuidadosamente y asegurarse de integrar correctamente los objetivos de aprendizaje.
Effects of Slice Thickness and Pre-Treatment Concentration on the Quality Characteristics of Solar Dried Pineapple
Authors: Ainebyona Paddy Isa , Yekoyada Musoke , Kigozi Julia , Agnes Nabubuya
Published: August 2023

The overall goal of this study was to determine the quality changes (vitamin C retention, browning, rehydration ratio) that occur during solar drying of pineapple as influenced by different processing conditions (slice thickness and pre-treatment concentration). Pineapple fruits were sliced to varying thicknesses (5 and 10 mm), pre-treated at different concentrations of citric acid (2, 5, and 10 g/l), and dried for 2 days in a Hohenheim model type solar tunnel dryer until a safe moisture level about ≤15% was reached. Samples were analyzed for changes in quality characteristics using standard AOAC methods. Dried pineapple slices were found to differ significantly in terms of browning scores and vitamin C retention (p≤0.05) while no differences were observed in the rehydration ratio (p>0.05). Slice thickness and pre-treatment concentration were observed to have a significant interaction effect on the browning score/index of pineapple slices during drying (p≤0.05). Overall vitamin C concentration increased for samples during the drying process with the maximum vitamin C concentration being 36.85 mg/100 g recorded in 5mm thickness samples pre-treated with 5% citric acid solution. Maximum vitamin C retention was recorded in samples sliced to 5mm thickness and pre-treated with 5 g/l citric acid solution (15.68) while minimum vitamin C retention (2.41) was recorded in 5mm slices treated with a 10 g/l citric acid solution. Rehydration ratio ranged from 1.60 to 2.53. There was no significant difference between the rehydration ratio between the different treatments at P≤0.05. The lowest browning index was observed in samples sliced to 10 mm thickness and treated at 5 g/l while the highest browning index was observed in samples sliced to 5mm and treated at 5 g/l of citric acid. The best-optimized conditions obtained for the given criteria were 5 mm slice thickness and 2 g/l pre-treatment concentration based on a maximum desirability of 0.639. For the optimized combination of drying parameters, the vitamin C content, the rehydration ratio, and the browning were 9.14, 2.43 and 0.47, respectively.
Analysis of the environmental resources value and enterprises economic benefits based on combination algorithm
Authors: Chen Dan
Published: August 2023

To solve the problems of fuzziness, nonlinearity and complexity of economic factors and environmental factors in the evaluation of ecological economic benefits of enterprises are studied. Based on the theory of environmental-economic benefits (EEB), this paper defines the value of environmental resources and economic benefits of enterprises, and puts forward the indicators of environmental and economic benefits. The evaluation model of enterprise EEB based on the analytic hierarchy process and fuzzy set algorithm is constructed. By establishing the hierarchical structure model of index system, the intuitive fuzzy judgement matrix is obtained, and the final score of enterprise environmental benefits is calculated by consistency test and weight analysis. After verifying the model, the evaluation method of enterprise EEB proposed in this paper is accurate and reliable, which is helpful to deeply analyse the hidden order and adaptation mechanism of complex adaptation system of enterprise environmental management.
Calculation and evaluation of similarity in sports information resources based on combined algorithm
Authors: Zhou Shuang
Published: August 2023

It is helpful for athletes to obtain real-time and accurate sports information resources by integrating various recommendation algorithms into a personalised sports recommendation system. Therefore, this paper designs user-based and content-based recommendation algorithms, and recommends their results to sporters by weighted selection. In addition, by acquiring the characteristics of sporters, the method of the constraint space of core parameters is determined by using ontology rule reasoning, which ensures the rationality of sports parameter extraction, and thus establishes the similarity calculation model of sports resources and designs the strategy and method of model verification. Finally, the validity of the model is evaluated by Mahalanobis distance, and the recommendation effects of different algorithms are compared by similarity grade, which can provide sporters with personalised sports resources with stronger pertinence and better effect.
Assessment of the Commercially Available Chemical Space for Using in the 19F NMR FAXS Method: a Enamine Ltd. Case
Authors: Oksiuta Oleksandr V. , Filatov Yaroslav I.
Published: August 2023

Aim. To analyze commercially available fluorine containing compounds for the possibility of their use in the 19F NMR FAXS method.Materials and methods. The selection of fluorine-containing fragments for the study was performed using 3.9 million instock screening compounds and 248,000 in-stock building-blocks from Enamine Ltd library. The selection and classification of the compounds was carried out using the DataWarrior and KNIME software. The Fluorinated Fragments library of Enamine Ltd. containing 6377 compounds, was also analyzed. To analyze the abovementioned sets of substances, the multistep workflows specially designed were used.Results and discussion. As a result of applying the workflow developed to the compound sets (both screening compounds and building blocks), 13 800 compounds were selected and further classified according to the presence of one out of 12 fluorine-containing groups. The Fluorinated Fragments library was also subjected to a similar workflow. For the latter, 8 out of 12 fluorine-containing groups were identified. Additionally, experimental 19F NMR chemical shift values for Fluorinated Fragments library compounds spectra were analyzed. It has been found that some structural classes have areas of chemical shifts intersection. On the other hand, the ranges from –40 to –60 ppm and beyond –160 ppm are free from any group of compounds from the library analyzed.Conclusions. The analysis has shown that commercially available fluorine-containing fragments do not satisfy the needs of the 19F NMR FAXS method, and further expansion of the chemical space of fluorine-containing compounds by increasing their diversity is required.
The Synthesis of the Hydrogenated Thiophenes by [3+2] Cycloaddition Reaction of Thiocarbonyl Ylide
Authors: Rudenko Tymofii V. , Timoshenko Vadim M.
Published: August 2023

Aim. To study the use of chloromethyl trimethylsilylmethyl sulfide as a precursor of thiocarbonyl ylide in [3+2] cycloaddition reaction to a number of α,β-unsaturated compounds and to establish the regularities of the reaction course. To develop an effective method for the synthesis of new dihydro- and tetrahydrothiophene derivatives which are convenient for further modification.Results and discussion. The synthetic approach to tetrahydrothiophenes with substituents in positions 3 and 4 was extended by the [3+2] cycloaddition reaction of thiocarbonyl ylide with a number of compounds containing an activated multiple bond. The stereoselectivity and limitations of this reaction were determined. Further functionalization of the obtained compounds was carried out.Experimental part. Thiocarbonyl ylide was obtained by fluoride ion-promoted 1,3-desilylation of the known chloromethyl trimethylsilylmethyl sulfide. The synthesis of the target compounds involved the [3+2] cycloaddition of such an ylide to a series of compounds with an activated multiple bond. The stereochemistry of the target compounds was determined by 1H NOESY experiments. Synthetic derivatives of thiolancarboxylic acids, in particular aldehydes, alcohols, amines, amidines, were obtained by functionalization of the [3+2] adducts.Conclusions. The synthetic approach to functionalized tetrahydrothiophenes by the [3+2] cycloaddition reaction of thiocarbonyl ylide with a number of compounds containing an activated multiple bond has expanded the limits of application of this reaction and allows obtaining the target compounds in multigram quantities. A high stereoselectivity of this reaction was observed. The reaction products are convenient synthetic precursors to the various classes of organic compounds.
Electrophilic Reactions of 7-(Trifluoromethyl)-2,3-dihydro- 1H-pyrrolizine: a Way Towards New Building Blocks
Authors: Klipkov Anton A. , Gerus Igor I.
Published: August 2023

Aim. To synthesize new fluoro-containing building blocks for medicinal chemistry purposes using electrophilic reactions of 7-(trifluoromethyl)-2,3-dihydro-1H-pyrrolizine.Results and discussion. Synthetic approaches to 5-halogeno- and 5-acyl-7-(trifluoromethyl)-2,3-dihydro-1H-pyrrolizines have been developed. The obtained new trifluoromethyl-containing pyrrolyzines are promising building blocks for medicinal chemistry.Experimental part. The synthesis of the target compounds began with known 7-(trifluoromethyl)-2,3-dihydro-1H-pyrrolizine and included halogenation and acylation reactions using N-halogen succinimides and acylating reagents.Conclusions. New synthetic approaches to a number of 7-(trifluoromethyl)-2,3-dihydro-1H-pyrrolizines with various substituents, such as halogen atoms or acyl groups, at the position 5 of the pyrrole ring have been developed. This opens the door to the use of such promising trifluoromethyl-containing building blocks for medicinal chemistry needs.
Development of a Personnel and Payroll Information System at Madrasah Ibtidaiyah Misbahun Nasyiin School
Authors: Purnama Putra , Dian Pratiwi  , Salim Agus
Published: August 2023

MI. Misbahunnasyiin is an Islamic educational institution located on Jl Raden Saleh, Tangerang. MI Misbahunnasyiin has administrative and financial data that is still recorded manually, which is very dangerous and vulnerable or at risk of data loss and damage. so that this research aims to find a solution to solve this problem by making applications related to digitalized payroll and staffing so that it can facilitate user performance and solve problems that existed before. Then writing study This is expected to simplify and increase efficiency in data processing and help develop information systems at the MI Misbahunnasyiin school using the language of them program PHP and MySql as server database.
Transtorno alimentar na adolescência
Authors: Appolinário José Carlos Borges , Vasconcelos Fátima
Published: August 2023

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Entendendo o TDAH (foco em adultos)
Authors: Louzã Neto Mario Rodrigues , Polanczyk Guilherme Vanoni
Published: August 2023

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Saúde mental do médico pós pandemia: o que mudou? E agora, doutor?
Authors: Danila Arthur Hirschfeld , Humes Eduardo de Castro , Luz Leonardo Sérvio
Published: August 2023

Muito se fala sobre a saúde mental da população após a pandemia de covid-19, mas e a saúde dos médicos que trabalharam diretamente na linha de frente? Segundo dados da Organização Mundial da Saúde - OMS, a prevalência global de ansiedade e depressão aumentou cerca 25%. Para falar sobre o assunto, o ABP TV desta terça-feira recebe membros da Comissão de Atenção à Saúde Mental do Médico que nos trarão mais informações acerca do tema.
The Role of President Xi Jinping in building the Chinese National Identity
Authors: Barzan Jalal Himed  , Mohammed Shattab Edan
Published: August 2023

The national identity of a society such as the Chinese community is ethnically, religiously and linguistically diverse, and it needs leadership and leadership capable of managing this diversity, and this was embodied in the efforts made by Xi Jinping through government measures or the procedures and instructions taken by the Chinese Communist Party, which mostly express The ideas and aspirations of Xi Jinping, and the role of the Chinese leader in managing this diversity has been embodied through a set of policies, decisions and initiatives at various levels and political, economic, social and cultural aspects, some within society with the aim of bringing about a quantum leap in the level of modernization and development of Chinese society and the other external in order to achieve the dream of the Chinese nation In terms of openness and progress, Xi Jinping's efforts were embodied in completing some of the efforts of his predecessors and others through the initiatives and policies he launched, all of which aim to preserve the unity of China and preserve the identity of the Chinese nation.
Information wars in the security and military field - America and China
Authors: Saleh Shaimaa Turkan
Published: August 2023

Author: Dr. Firas Jamal Shaker

Place and date of publication: Al-Araby for Publishing and Distribution,

Cairo - Egypt, 2022.

Number of pages of the book: 304 pages
Gas Permeability and Flexural Strength of Impacted Composites for Cryogenic Propellant Tanks
Authors: Saha Shuvam , Sullivan Rani W.
Published: August 2023

Reusable composite cryogenic tanks may be used in next-generation space launch systems due to their several benefits, such as increased specific strength, tailorability, and low coefficient of thermal expansion. However, transverse microcracks within composites due to thermal stresses and barely visible impact damage can cause cryogenic fuel to leak through the walls of the tank. The objective of the present study is to evaluate the gas permeability of impacted and thermally cycled composites and correlate it to their postimpact residual strength. Cross-ply carbon/epoxy composites ([Formula: see text]) fabricated from unidirectional prepregs were subjected to 20 cryogenic cycles from ambient to cryogenic temperatures ([Formula: see text]). Barely visible impact damage at two different impact velocities ([Formula: see text] and [Formula: see text]) was imparted to the specimens at room and cryogenic temperatures before and after cryogenic cycling. The composites’ gas permeability, residual flexural strength, and absorbed energy were measured and correlated. Composite specimens subjected to impact at room temperature had higher gas permeability and absorbed energy with lower residual flexural strength. A linear relationship was observed between gas permeability, absorbed energy, and postimpact flexural strength. Two linear models to predict gas permeability with absorbed energy and flexural strength as variables have been presented for impacted and cryogenically cycled specimens with an [Formula: see text] value of at least 96%.
Detailed Performance Studies on a Small Electric-Powered Contra-Rotating Ducted Fan Engine
Authors: Ebus Tobias , Dietz Markus , Hupfer Andreas
Published: August 2023

Electrical propulsion has been identified as one of the key fields of future research within the aerospace sector. This paper aims to contribute to the ongoing development of small electric-powered ducted fan engines with a thrust in the range of a few hundred newtons. A special emphasis is placed on introducing contra-rotating fans to such engines. Recently, such an innovative contra-rotating engine has been developed and put into operation on a novel test bench. This study intends to take a closer look at the performance of the engine at design speed ratio by means of experimental and numerical investigations. Global performance parameters are analyzed to validate parallel numerical simulations. Results indicate that both experiment and simulation are in good agreement. Moreover, detailed flow studies of the spanwise distribution of relevant parameters are conducted, and results are discussed. From these results, the stall behavior of the stage is identified. Finally, a comprehensive performance map is established with the help of a number of numerical simulations, which reveal a good off-design performance behavior of the engine.
Spin Aerodynamic Modeling for a Fixed-Wing Aircraft Using Flight Data
Authors: Gresham James L. , Simmons Benjamin M. , Hopwood Jeremy W. , Woolsey Craig A.
Published: August 2023

Novel techniques are used to identify a nonlinear, quasi-steady, coupled, spin aerodynamic model for a fixed-wing aircraft from flight-test data. Orthogonal phase-optimized multisine inputs are used as excitation signals while collecting spinning flight data. A novel vector decomposition of explanatory variables leads to an elegant model structure for spin flight data analysis. Results show good agreement between model predictions and validation flight data. This effort is motivated by interest in developing a flight termination system for a fixed-wing unmanned aircraft that controls a descending spiral trajectory flight path toward a designated impact area. While investigating the feasibility of a robust control method to guide the spinning trajectory, it was helpful to compare a level flight dynamic model with one of the aircraft dynamics and control authority in the neighborhood of a stable, oscillatory spin. In this paper, a nominal flight aerodynamic model is developed and compared to the stall spin model and the spin model outperforms the nominal model for spinning flight.
Aeroelastic Analysis of Actuated Adaptive Wingtips Based on Pressure Actuation
Authors: Meyer Patrick , Hühne Christian , Bramsiepe Kjell , Krüger Wolf
Published: August 2023

Folding wingtips address the challenges posed by high-aspect-ratio wings, such as airport conformity and increased wing root bending moment. Actuated adaptive wingtips extend the functionalities of folding wingtips by using a stiffness-adaptive aeroelastic hinge that is actively adjustable in flight. The objective of this paper is the aeroelastic analysis of a wing equipped with an adaptive-stiffness hinge. While the structural design of the wingtip actuator based on pressure-actuated cellular structures (PACS) was developed in a previous study, in this study the authors verify the concept of actuated adaptive wingtips through aeroelastic analysis. This study shows that the investigated PACS actuator, structurally designed from glass-fiber-reinforced plastic, is capable of bearing the loads acting on the wingtips of a Cessna Citation X. The adaptive-stiffness hinge, positioned between 86.7 and 91.2% of the semispan, reduces the wing root bending moment by up to 7.8% in a 2.5[Formula: see text] maneuver load case, while keeping the wing straight in cruise. A further increase in load alleviation potential can be achieved in the future by extending the actuator’s operating envelope and thus increasing its load-bearing capacity. The functional verification of the actuated adaptive wingtip concept by means of aeroelastic analysis forms the basis for the manufacturing and testing of a functional prototype.
Effect of Plasma-Enhanced Low-Temperature Chemistry on Deflagration-to-Detonation Transition in a Microchannel
Authors: Vorenkamp Madeline , Steinmetz Scott , Mao Xingqian , Shi Zhiyu , Starikovskiy Andrey , Ju Yiguang , Kliewer Christopher
Published: August 2023

This study examines low-temperature chemistry (LTC) enhancement by nanosecond dielectric barrier discharge (ns-DBD) plasma on a dimethyl ether (DME)/oxygen [Formula: see text] (Ar) premixture for deflagration-to-detonation transition (DDT) in a microchannel. It is found that non-equilibrium plasma generates active species and kinetically accelerates LTC of DME and DDT. In situ laser diagnostics and computational modeling examine the influence of the ns-DBDs on the LTC of DME and DDT using formaldehyde ([Formula: see text]) laser-induced fluorescence (LIF) and high-speed imaging. Firstly, high-speed imaging in combination with LIF is used to trace the presence of LTC throughout the flame front propagation and DDT. Then, competition between plasma-enhanced LTC of ignition and reduced heat release rate of combustion due to plasma-assisted partial fuel oxidation is studied with LIF. Observations of plasma-enhanced LTC effects on DDT are interpreted with the aid of detailed kinetic simulations. The results show that an appropriate number of ns-DBDs enhances LTC of DME and increases [Formula: see text] formation and low-temperature ignition, accelerating DDT. Moreover, it is found that, with many ns-DBDs, [Formula: see text] concentration decreases, indicating that excessive discharges may accelerate fuel oxidation in the premixture, reducing heat release and weakening shock–ignition coupling, inhibiting DDT.
Numerical Study of Aerodynamic Characteristics of No-Swinging and Free-to-Swing Cross Parachute
Authors: Hou Xiayi , Hu Jun , Yu Yong
Published: August 2023

During wind-tunnel experiments on parachutes, it is common to either fix the apex of the canopy to maintain a specific angle of attack or only fix the confluence point of the suspension lines to allow the canopy to move freely. These no-swinging and free-to-swing conditions affect considerably the aerodynamic characteristics of the parachute. This paper investigates the influence of these conditions on the aerodynamic characteristics and dynamic motion characteristics of both symmetric cross parachutes with eight equal suspension lines, and asymmetric cross parachutes with two (of eight) shortened suspension lines. The research reveals that the canopy of a no-swinging cross parachute exhibits a spinning motion around its axis. The free-to-swing parachute undergoes a conical swing motion around the suspension-line confluence point. The frequency of spin and conical swing increases in proportion to [Formula: see text]. The magnitude and direction of the lift force varies periodically owing to the conical swing of the free-to-swing parachute. Conversely, the no-swinging parachute, at a fixed angle of attack, maintains a comparatively stable lift force. The free-to-swing asymmetric cross parachute produces a stronger lift force because of the larger swing angle compared to the symmetric parachute. The resultant asymmetry in the aerodynamic shape caused by the shortening of suspension lines has minimal effect on aerodynamic characteristics.
Comportamento sexual dos estudantes do ensino superior
Authors: Couto Ana Carolina Benvenuti , Silva Augusto Teixeira , Picinin Giovanna Luiza de Sá , Silva Herbert Gonçalves da , Caldeira Maria Vitória Rodrigues , Zimmermmann Juliana Barroso
Published: August 2023

Objetivo:  Avaliar o comportamento sexual de alunos do ensino superior. Métodos: Trata-se de um estudo transversal onde se realizou a confecção de um questionário no aplicativo Google Forms abordando aspectos do comportamento sexual de jovens do ensino superior e dados sociodemográficos (idade, gestações, partos, abortos, vida sexual nos últimos 7 e 30 dias, uso de condon, presença de infecção sexualmente transmissível (IST) e tratamento. Resultados: A grande maioria dos alunos estava entre 20 a 30  anos de idade (75,6%) e eram da área de saúde (78,5%). 65,4% eram mulheres e nuligestas (90,8%). O comportamento sexual de risco mais frequente foi o sexo sem preservativo (n=89,8%; n=239) e uso abusivo de álcool (47,7%; n=127). A grande maioria se definiu como heterossexual (n=223; 71,5%). O principal motivo para ter atividade sexual sem condon foi a estabilidade com o parceiro (64,1%) e a confiança (17,2%). Entretanto, 17,5% já tiveram alguma IST e 29,9% não comunicaram ao parceiro sobre a infecção.  O tratamento foi realizado conforme prescrito apenas em 38,1%. Dentre as principais IST diagnosticadas destacaram-se o HPV (16,3%) e a sífilis (11,5%). Conclusão: Os jovens apresentaram comportamento sexual inseguro e isso os torna vulneráveis às IST, mesmo quando estão no ensino superior.
COATI: multi-modal contrastive pre-training for representing and traversing chemical space
Authors: Kaufman Benjamin , Williams Edward , Underkoffler Carl , Pederson Ryan , Mardirossian Narbe , Watson Ian , Parkhill John
Published: August 2023

Creating a successful small molecule drug is a challenging multi-parameter optimization problem in an effectively infinite space of possible molecules. Generative models have emerged as powerful tools for traversing data manifolds comprised of images, sounds, and text, and offer an opportunity to dramatically improve the drug discovery and design process. To create generative optimization methods that are more useful than brute-force molecular generation and filtering via virtual screening, we propose that four integrated features are necessary: large, quantitative datasets of molecular structure and activity, an invertible vector representation of realistic accessible molecules, smooth and differentiable regressors that quantify uncertainty, and algorithms to simultaneously optimize properties of interest. Over the course of 12 months, Terray has collected a dataset of 2 billion quantitative binding measurements, which directly motivates multi-parameter generative optimization of molecules conditioned on this data. To this end, we present COATI, a pre-trained, multi-modal encoder-decoder model of druglike chemical space. COATI is constructed without any human biasing of features, using contrastive learning from text and 3D representations of molecules to allow downstream use with structural models. We demonstrate that COATI possesses many of the desired properties of a universal molecular embedding: fixed-dimension, invertibility, autoencoding, accurate regression, and low computation cost. Finally, we present a novel metadynamics algorithm for generative optimization using a small subset of our proprietary data collected for a model protein, Carbonic Anhydrase, designing molecules that satisfy the multi-parameter optimization task of potency, solubility, and druglikeness. This work sets the stage for fully-integrated generative molecular design and optimization for small molecules.
Food Chemicals in Epigenetic Targets: Towards an Epi Food Chemical Database
Authors: Juárez-Mercado K. Eurídice , Avellaneda-Tamayo Juan F. , Villegas-Quintero Hassan , Chávez-Hernández Ana L. , López-López Claudia Daniela , Medina-Franco José L.
Published: August 2023

There is an increasing awareness of the importance of epigenetics to understand disease etiologies and develop novel therapeutics. Concomitantly, the renewed interest in epigenetic processes and their relationship with food chemicals has been reflected by an increasing number of publications in the past few years. However, there is a lack of a recent systematic and quantitative study that accounts for the most recent advances in the area associating the chemical structures of the food and natural product components with their biological activity. Here, we analyze recent advances and discuss the status of food chemicals and their intersection with natural products in epigenetic research. We discuss the most investigated diseases and potential therapeutic applications associated with food chemicals and natural compounds ingested in the diet. Using chemoinformatics tools, we compared quantitatively chemical contents, structural diversity, and coverage in the chemical space of food chemicals reported with epigenetic activity. As part of this work, we built and curated a compound database of food and natural product chemicals annotated with structural information, epigenetic target activity profile, and main source of the food chemical or natural product, among other relevant features. The compounds are cross-linked with identifiers from other major public databases such as FooDB and the COlleCtion of Open Natural ProdUcTs, COCONUT. The compound database is freely accessible at https://github.com/EuridiceJuarez/EpiFoodChemicalDatabase/blob/main/EpiFoodChemicalDatabase.csv.