bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficient Transport and Biotransformation of Dipeptide-like Tyrosine/
Phenylalanine-Conjugated Phenolic Amide Esters in THP-1 Cells
and PBMCs: A Potential Means for Transporting Compounds Inside
Monocytes/Macrophages
Authors: Park Jae B.
Published: December 2021

Background:

Recent studies suggest that dipeptide-like tyrosine/phenylalanine-conjugated
phenolic amide compounds may contain several biological activities, including anti-inflammatory
activity. However, there is currently no information about their transport and biotransformation
in monocytes/macrophages involved in inflammation process.

Objective:

The objective of this study was to investigate cell transport and biotransformation of the
phenolic amides and esters in monocyte/macrophage-like cells.

Methods:

Cell transport and biotransformation of the phenolic amides and esters (N-coumaroylphenylalanine,
N-caffeoylphenylalanine, N-feruloylphenylalanine, N-coumaroyltyrosine, Ncaffeoyltyrosine,
N-feruloyltyrosine, and their O-methyl esters) were investigated in THP-1 cells
and PBMCs using HPLC, cellular, and kinetics methods.

Results:

In THP-1 cells, the phenolic amides were not transported significantly, but their O-methyl
esters were transported significantly (P < 0.02). Also, the transport of the esters was found to be
sodium-independent and pH-dependent. Among the tested esters, N-feruloylphenylalanine-Omethyl
ester showed the highest uptake (Km of 25 μM), and the uptake was inhibited by PepT1/2
substrate and blocker (GlySar and enalapril) in THP-1 cells. Particularly, enalapril competitively inhibited
the uptake with Ki of 560 μM. The data also showed that N-feruloylphenylalanine-Omethyl
ester and N-feruloyltyrosine-O-methyl ester could be biotransformed into parent phenolic
amides in THP-1 cells. Similarly, these ester compounds were also found to be transported and biotransformed
in PBMCs.

Conclusion:

The data suggest that dipeptide-like tyrosine/phenylalanine-conjugated phenolic
amide esters may be transported and biotransformed in THP-1 cells and PBMCs.
The Role of Molecular Modeling and Bioinformatics in Treating a Pandemic Disease: The Case of COVID-19
Authors: Abdelsattar Abdallah S. , El-Awadly Zahraa M. , Abdelgawad Mai , Mahmoud Fayrouz , Allam Sahar A. , Helal Mohamed A.
Published: December 2021

The COVID-19 pandemic first appeared in Wuhan, China, in December 2019 in a cluster of pneumonia patients. The causative agent was found to be SARS-CoV-2. Here, we are summarizing current treatment strategies and highlighting the role of bioinformatics, molecular modeling, and structural biology during the COVID-19 pandemic. There are different pharmacological treatments, mostly repurposed drugs, employed for the treatment of COVID-19, including antiviral drugs, corticosteroids, biologic drugs, antibiotics, antifungal agents, and anticoagulants. Some immune-based therapies are also under evaluation, including convalescent plasma, IL-1, IL-6 inhibitors, and interferons. Different bioinformatics networks are established to provide information about the structure, transcriptome, and pathogenicity of the virus. The genotyping analysis for SARS-CoV-2 is also useful in identifying different mutations, SNPs, and conservative domains along the viral genome. Cryo-EM and X-ray diffraction had a crucial role in determining the structure of viral proteins such as spike (S) protein, main protease, and RdRp. NMR had a minor role and determining the structure of nucleocapsid (N) protein only. Several docking studies were performed to predict the interaction of certain FDA-approved drugs with known efficacy and toxicity, while others used natural products. Among different study types, in silico drug prediction and repurposing have the lowest risk with less off-target results. Therefore, bioinformatics and in silico studies have an important role during pandemics in providing information about viral structure and function and predicting potential treatments.
Histamine Detection in Mackerel (Scomberomorus Sp.) and its Products Derivatized with 9-Flourenilmethylchloroformate
Authors: Munir Muhammad Abdurrahman , Badri Khairiah Haji , Heng Lee Yook , Mackeen Muhammad Mukram Mohamed , Sage Edison Eukun
Published: December 2021

Histamine is commonly present in food containing proteins, like in mackerel. Consuming fish is imperative for the improvement of human muscles. Nevertheless, some studies reported ingesting fish containing histamine more than 50 mg·kg-1 can cause toxicity. This study analyzed and determined the composition of histamine in mackerel and its products commonly consumed in Malaysia, especially on the East Coast of Malaysia. These included processed mackerel such as canned products, satay (skewed fish) and keropok lekor (fish cake/ cracker). Histamine analysis was performed using High Performance Liquid Chromatography (HPLC) equipped with a fluorescence detector. A derivatizing reaction was applied to increase the sensitivity of HPLC to histamine using 9-flourenilmethylchloroformate (FMOC-Cl). The chromatographic separation was achieved in 15 min. Method validation was in accordance to Commission Decision 657/2002/CE. The linear range was at 0.16 – 5.00 µg·mL-1 (histamine) with the LOD at 0.10 µg·mL-1 and LOQ at 0.30 µg·mL-1 . Method applicability was checked on seven real samples involving raw, cooked, and dry products, yielding acceptable recovery.
Synthesis of Isopulegol Through Cyclisation of Citronellal Using Solid Acid Catalysts: Catalytic Reaction Performance Evaluation and Process Parameters Optimization
Authors: Shah Abdul Karim , Kandhro Ghulam Abbas , Shah Aqeel Ahmed , Bukhari Syed Nizam Uddin Shah , Iqbal Arshad , Usto Muhammad Azam , Laghari Taswar Hussain , Ahmed Sohail
Published: December 2021

The cyclisation of citronellal to isopulegol is a significant intermediate stage in the production of menthols. In this research work, the effects of acid treatment on montmorillonite clay have been investigated and used in citronellal cyclisation reactions. Furthermore, the effects of acid treatment and hetero-poly acid impregnation have been determined on the textural and catalytic properties of montmorillonite clay. The designed catalysts were characterized by XRD, N2 sorption, and NH3- TPD techniques. Acid treatment of montmorillonite resulted in the enhancement of surface area and pore volume. The catalytic activity and selectivity parameters were lessened due to the severe leaching of Al ions from tetrahedral crystalline structures (e.g., weakened structure and loss of acidity). Among all prepared materials, the heteropoly acid supported HCl treated montmorillonite catalyst was observed as a more active, stable, and selective catalyst that showed the highest catalytic performance in citronellal cyclisation under optimized process parameters. The catalytic activity and selectivity were enhanced with rising mesoporosity and acidity parameters due to HCl acid treatment and HPA impregnation.
Occurrence, Levels and Spatial Distribution of Polybrominated Diphenyl Ethers: Case Study of Elemi River in Ado-Ekiti, Nigeria
Authors: Ibigbami Olayinka Abidemi
Published: December 2021

Polybrominated diphenyl ethers (PBDEs) were seasonally determined in water and sediments of the Elemi River, Nigeria using gas chromatography analysis. Samples were collected in two consecutive seasons for six months, monitoring the program every month. Three BDEs congeners (28, 47 and 154) were only detected with the mean concentration of ND - 0.001 µg/L and ND - 0.143 µg/kg in water and sediments, respectively. BDEs (99, 100, 153, 183 and 209) were consistently absent in both seasons. The distribution of BDEs showed that BDE 28 was consistently found in the water samples throughout the months of sampling, while the sediments sparingly contained BDE 28 and 47. The study proposed the need for effective measures to reduce the deleterious contribution of these persistent compounds into the rivers.
Assessment of Cadmium Toxicity in Drinking Water of Eight Talukas of Upper Sindh
Authors: Shar Noorul Hassan , Shar Ghulam Qadir
Published: December 2021

In the present study, 240 groundwater samples were collected from eight Talukas of upper Sindh. The cadmium (Cd) content was determined by atomic absorption spectrophotometer. Concentration (µg/L), Daily Intake ofMetals (DIM),Health Risk Indexes (HRI) for children and adults caused due to Cd were measured through equations of EPA and WHO. Mean concentration of Cd in different Talukas of upper Sindh was found as; Daharki (6.20 µg/L), Ubauro (7.73 µg/L), Kashmore (7.53 µg/L), Tangwani (7.73 µg/L), Garhi Khairo (6.20 µg/L), Thul (5.00 µg/L), Qambar (7.674 µg/L) and Miro Khan (7.47 µg/L). Moreover, percent contamination of each Taluka was found as, Daharki (80%), Ubauro (93%), Kashmore (93%), Tangwani (93%), Gharhi Khairo (70%), Thul (56%), Qambar (93%) and Miro Khan (93%). The DIM of Cd for adult and children was calculated the range for adults was found as; Daharki (0.00006 - 0.00036), Ubauro (0.00006 - 0.00042), Kashmore (0.00006 - 0.00036), Tangwani (0.00006 - 0.00042), Garhi Khairo (0.00003 - 0.00056), Thul (0.00003 - 0.00056), Qambar (0.00008 - 0.00039) and Miro Khan (0.00008 - 0.00039) mg/kg-d, whereas, for children DIM of Cd was found lower than adults. The HRI values show that children compared to adults are under the potential risk threat due to HRI values > 1. Therefore, it can be suggested that groundwater found in above stated areas is unsafe for drinking purposes and must be treated before consumption.
Antioxidant Potential, Phenolics Content and Antimicrobial Attributes of Selected Medicinal Plant
Authors: Abbas Ali , Sultana Bushra , Hussain Anwaar , Anwar Farooq , Ahmad Naveed
Published: December 2021

The bioactive extracts recovered from Curcuma longa (stem), Mentha aquatica (stem and leaves), Emblica officinalis (fruits), Nigella sativa (seeds), and Glycyrrhiza glabra (stem) using methanol and ethanol, were appraised for antioxidant (total flavonoid contents, total phenolic contents, DPPH free radical scavenging ability, inhibition of linoleic acid peroxidation and reducing power) and antimicrobial attributes. Total phenolics (16.89 ± 0.18 - 25.06 ± 0.31g GAE/100g) and total flavonoids (1.96 ± 0.07 - 13.54 ± 0.18 CE g/100g) contents of aqueous methanol extracts of tested plant materials were significantly (p < 0.05) lower than that of aqueous ethanol extracts (13.87 ± 0.12 - 28.63 ± 0.34 g GAE/100g) and (2.20 ± 0.10 - 8.71 ± 0.24 CE /100g), respectively. The percent inhibition of linoleic acid per oxidation by crude ethanol extracts of plants was in the range of 48.72 ± 1.24 - 70.79 ± 1.57 and crude methanol extract 35.90 ± 1.28 - 61.54 ± 2.14, while the range of DPPH free radical scavenging activity of ethanol extracts was (58.36 ± 1.98 - 80.55 ± 3.07) and methanol extracts (39.55 ± 1.52 - 79.64± 2.33). The reducing power of the tested extracts obtained by ethanol (at the concentration of 10 mg/mL) ranged 1.11 ± 0.12 – 1.53 ± 0.18 while for methanol extracts 0.98 ± 0.11 – 1.39 ± 0.12. Among the attributes analyzed, total phenolics, total flavonoids, and DPPH free scavenging activity were found to be varied significantly in all the tested medicinal plants. The extracts from all plants showed good antimicrobial potential against a penal of bacteria, including E. coli, P. multocida and S. aureus, and fungi including A. niger, A. flavus, A. alternate, and G. lucidium. Overall, the tested samples were found to be a good source of natural antioxidant and antimicrobial agents and thus can be explored for potential functional food and nutra-pharmaceutical applications.
Spectrofluorimetric Determination of Some N. Containing Medicines Using Rhodamine 6G as a Chromogenic Reagent
Authors: Al-Sabha Theia'a Najim , Dhamra Mohamed Yahya
Published: December 2021

A sensitive spectrofluorimetric method has been developed for the analysis of some medicines containing primary, secondary, and tertiary amino groups, namely Diclofenac (DIC), Domperidone (DOM), Famotidine (FAM), and Propranolol (PRO), in their pure and medicinal forms. The method is based on the quenching of the fluorescence intensity of rhodamine 6G (R6G) through the formation of ion-pair complexes between the above medicines and the R-6G reagent, which is measured at 552 nm after excitation at 402 nm. The calibration graphs were rectilinear in the concentration ranges of 0.10- 9.00, 0.05-15.00, 0.10-14.0 and 0.05-5.00 µg mL-1 for above medicines respectively. The recovery (%) values were ranged between 99.45%- 100.97%. The detection limits ranged in the concentration of 0.243-0.754 µg/mL, and the limits of quantitation were 0.806- 2.420 µgmL-1 for all drugs. The method was successfully applied for the determination of these drugs in their pharmaceutical preparations.
living wage of workers in Vietnam
Authors: Tung Phuong Huu
Published: December 2021

Currently, Vietnam implements wage policy making through the important tool of minimum wage. However, the reality shows that the use of the minimum wage to pay employees is still inadequate and far from reality. Instead of using the minimum wage, a number of developed countries have recently used a new concept in wage policy making, which is “living wage” with high efficiency. In line with the trend of the world, the living wage needs to be recognized and researched and applied in practice in Vietnam to bring about more positive effects, ensuring the life of employees and the whole family. sustainable development of enterprises.
The Donor – Recipient Weight Ratio is a Reliable Marker for Cell Yield in Hematopoietic Stem Cell Donations
Authors:   Blood & Marrow Collection Program, MedStar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, D.C. 20007, USA, Rennert Wolfgang , Cormier Katie ,   Blood & Marrow Collection Program, MedStar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, D.C. 20007, USA, Sprott Samantha ,   Blood & Marrow Collection Program, MedStar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, D.C. 20007, USA
Published: December 2021

Bone marrow transplants remain an import source of hematopoietic stem cells for patients suffering from specific diseases like aplastic anemia, for pediatric patients with malignant and non-malignant blood cell disorders, and for situations in which graft-versus-host disease (GvHD) is a concern. Identifying the optimal donor to achieve a 3-5 x 108/kg of recipient weight TNC yield may be challenging. In an analysis of 687 consecutive donors, donor and procedure characteristics were related to TNC/kg of recipient weight using Spearman correlation coefficients as well as linear and multiple regression analysis. We found correlations between donor WBC (r = 0.17), donor platelet counts (r = 0.15), donor BMI (r = 0.10), and the percentage of donor estimated blood volume accessed for harvesting (r = -0.57) with TNC/kg of recipient weight. The strongest correlation existed between the donor-recipient weight ratio and the TNC/kg (r = 84). In a multivariate regression analysis, the donor-recipient weight ratio influenced the TNC/kg of recipient weight more significantly (adjusted R2 = 0.84) than all other related variables put together. The minimal donor-recipient weight ratio associated with a TNC/kg of at least 3x108/kg of recipient weight was 0.8 (mean 3.425; 95% CI 2.01, 5.8). Using this donor-recipient ratio provides national bone marrow donor registries with a practical and simple measure to assure optimal cell yield outcomes in hematopoietic stem cell donations.
Text Mining of Adverse Events in Clinical Trials: Deep Learning Approach
Authors: Chopard Daphne , Treder Matthias S , Corcoran Padraig , Ahmed Nagheen , Johnson Claire , Busse Monica , Spasic Irena
Published: December 2021

Background

Pharmacovigilance and safety reporting, which involve processes for monitoring the use of medicines in clinical trials, play a critical role in the identification of previously unrecognized adverse events or changes in the patterns of adverse events.

Objective

This study aims to demonstrate the feasibility of automating the coding of adverse events described in the narrative section of the serious adverse event report forms to enable statistical analysis of the aforementioned patterns.

Methods

We used the Uniﬁed Medical Language System (UMLS) as the coding scheme, which integrates 217 source vocabularies, thus enabling coding against other relevant terminologies such as the International Classification of Diseases–10th Revision, Medical Dictionary for Regulatory Activities, and Systematized Nomenclature of Medicine). We used MetaMap, a highly configurable dictionary lookup software, to identify the mentions of the UMLS concepts. We trained a binary classifier using Bidirectional Encoder Representations from Transformers (BERT), a transformer-based language model that captures contextual relationships, to differentiate between mentions of the UMLS concepts that represented adverse events and those that did not.

Results

The model achieved a high F1 score of 0.8080, despite the class imbalance. This is 10.15 percent points lower than human-like performance but also 17.45 percent points higher than that of the baseline approach.

Conclusions

These results confirmed that automated coding of adverse events described in the narrative section of serious adverse event reports is feasible. Once coded, adverse events can be statistically analyzed so that any correlations with the trialed medicines can be estimated in a timely fashion.
Depressive Symptoms and Anxiety During the COVID-19 Pandemic: Large, Longitudinal, Cross-sectional Survey
Authors: MacDonald James J , Baxter-King Ryan , Vavreck Lynn , Naeim Arash , Wenger Neil , Sepucha Karen , Stanton Annette L
Published: December 2021

Background

The COVID-19 pandemic has influenced the mental health of millions across the globe. Understanding factors associated with depressive symptoms and anxiety across 12 months of the pandemic can help identify groups at higher risk and psychological processes that can be targeted to mitigate the long-term mental health impact of the pandemic.

Objective

This study aims to determine sociodemographic features, COVID-19-specific factors, and general psychological variables associated with depressive symptoms and anxiety over 12 months of the pandemic.

Methods

Nationwide, cross-sectional electronic surveys were implemented in May (n=14,636), July (n=14,936), October (n=14,946), and December (n=15,265) 2020 and March/April 2021 (n=14,557) in the United States. Survey results were weighted to be representative of the US population. The samples were drawn from a market research platform, with a 69% cooperation rate. Surveys assessed depressive symptoms in the past 2 weeks and anxiety in the past week, as well as sociodemographic features; COVID-19 restriction stress, worry, perceived risk, coping strategies, and exposure; intolerance of uncertainty; and loneliness.

Results

Across 12 months, an average of 24% of respondents reported moderate-to-severe depressive symptoms and 32% reported moderate-to-severe anxiety. Of the sociodemographic variables, age was most consistently associated with depressive symptoms and anxiety, with younger adults more likely to report higher levels of those outcomes. Intolerance of uncertainty and loneliness were consistently and strongly associated with the outcomes. Of the COVID-19-specific variables, stress from COVID-19 restrictions, worry about COVID-19, coping behaviors, and having COVID-19 were associated with a higher likelihood of depressive symptoms and anxiety.

Conclusions

Depressive symptoms and anxiety were high in younger adults, adults who reported restriction stress or worry about COVID-19 or who had had COVID-19, and those with intolerance of uncertainty and loneliness. Symptom monitoring as well as early and accessible intervention are recommended.
Integrating and Disseminating Pre-Exposure Prophylaxis (PrEP) Screening and Dispensing for Black Men Who Have Sex With Men in Atlanta, Georgia: Protocol for Community Pharmacies
Authors: Crawford Natalie D , Harrington Kristin R V , Alohan Daniel I , Sullivan Patrick S , Holland David P , Klepser Donald G , Quamina Alvan , Siegler Aaron J , Young Henry N
Published: December 2021

Background

Black men who have sex with men (BMSM) suffer from alarmingly high rates of HIV in the United States. Pre-exposure prophylaxis (PrEP) can reduce the risk of HIV infection by 99% among men who have sex with men, yet profound racial disparities in the uptake of PrEP persist. Low PrEP uptake in BMSM is driven by poor access to PrEP, including inconvenient locations of PrEP-prescribing physicians, distrust of physicians, and stigma, which limit communication about PrEP and its side effects. Previous work indicates that offering HIV prevention services in pharmacies located in low-income, underserved neighborhoods is feasible and can reduce stigma because pharmacies offer a host of less stigmatized health services (eg, vaccinations). We present a protocol for a pharmacy PrEP model that seeks to address challenges and barriers to pharmacy-based PrEP specifically for BMSM.

Objective

We aim to develop a sustainable pharmacy PrEP delivery model for BMSM that can be implemented to increase PrEP access in low-income, underserved neighborhoods.

Methods

This study design is a pilot intervention to test a pharmacy PrEP delivery model among pharmacy staff and BMSM. We will examine the PrEP delivery model’s feasibility, acceptability, and safety and gather early evidence of its impact and cost with respect to PrEP uptake. A mixed-methods approach will be performed, including three study phases: (1) a completed formative phase with qualitative interviews from key stakeholders; (2) a completed transitional pilot phase to assess customer eligibility and willingness to receive PrEP in pharmacies during COVID-19; and (3) a planned pilot intervention phase which will test the delivery model in 2 Atlanta pharmacies in low-income, underserved neighborhoods.

Results

Data from the formative phase showed strong support of pharmacy-based PrEP delivery among BMSM, pharmacists, and pharmacy staff. Important factors were identified to facilitate the implementation of PrEP screening and dissemination in pharmacies. During the transitional pilot phase, we identified 81 individuals who would have been eligible for the pilot phase.

Conclusions

Pharmacies have proven to be a feasible source for offering PrEP for White men who have sex with men but have failed to reach the most at-risk, vulnerable population (ie, BMSM). Increasing PrEP access and uptake will reduce HIV incidence and racial inequities in HIV. Translational studies are required to build further evidence and scale pharmacy-based PrEP services specifically for populations that are disconnected from HIV prevention resources.

International Registered Report Identifier (IRRID)

DERR1-10.2196/35590
Text Mining of Adverse Events in Clinical Trials: Deep Learning Approach (Preprint)
Authors: Chopard Daphne , Treder Matthias S , Corcoran Padraig , Ahmed Nagheen , Johnson Claire , Busse Monica , Spasic Irena
Published: December 2021

BACKGROUND

Pharmacovigilance and safety reporting, which involve processes for monitoring the use of medicines in clinical trials, play a critical role in the identification of previously unrecognized adverse events or changes in the patterns of adverse events.

OBJECTIVE

This study aims to demonstrate the feasibility of automating the coding of adverse events described in the narrative section of the serious adverse event report forms to enable statistical analysis of the aforementioned patterns.

METHODS

We used the Uniﬁed Medical Language System (UMLS) as the coding scheme, which integrates 217 source vocabularies, thus enabling coding against other relevant terminologies such as the International Classification of Diseases–10th Revision, Medical Dictionary for Regulatory Activities, and Systematized Nomenclature of Medicine). We used MetaMap, a highly configurable dictionary lookup software, to identify the mentions of the UMLS concepts. We trained a binary classifier using Bidirectional Encoder Representations from Transformers (BERT), a transformer-based language model that captures contextual relationships, to differentiate between mentions of the UMLS concepts that represented adverse events and those that did not.

RESULTS

The model achieved a high F1 score of 0.8080, despite the class imbalance. This is 10.15 percent points lower than human-like performance but also 17.45 percent points higher than that of the baseline approach.

CONCLUSIONS

These results confirmed that automated coding of adverse events described in the narrative section of serious adverse event reports is feasible. Once coded, adverse events can be statistically analyzed so that any correlations with the trialed medicines can be estimated in a timely fashion.
Effects of Integrating Family Planning With Maternal, Newborn, and Child Health Services on Uptake of Voluntary Modern Contraceptive Methods in Rural Pakistan: Protocol for a Quasi-experimental Study (Preprint)
Authors: Memon Zahid Ali , Reale Sophie , Ahmed Wardah , Spencer Rachael , Lashari Talib Hussain , Bhutta Zulfiqar , Soltani Hora
Published: December 2021

BACKGROUND

The uptake of modern contraceptive methods (MCMs) remains low, with 25% of women reporting their use in Pakistan. The overarching interventions covering service delivery platforms at facility and community levels necessitate the integration of family planning (FP) with maternal, newborn, and child health (MNCH) services.

OBJECTIVE

The main aim of this study is to evaluate the impact of an integrated FP-MNCH service delivery model to increase coverage of MCMs in rural Pakistan. Moreover, we aim to measure the level of effectiveness of interventions regarding the uptake of MCMs.

METHODS

A quasi-experimental, sequential, mixed methods study design with pre- and postevaluation will be adopted to evaluate the impact of integration of FP with MNCH services. The interventions include the following: (1) capacity strengthening of health care providers, including technical trainings; training in counseling of women who attend immunization centers, antenatal care (ANC) clinics, and postnatal care (PNC) clinics; and provision of job aids; (2) counseling of women and girls attending ANC, PNC, and pediatric clinics; (3) ensuring sustained provision of supplies and commodities; (4) community engagement, including establishing adolescent-friendly spaces; and (5) use of District Health Information System data in decision-making. Descriptive statistics will be used to estimate prevalence (ie, proportions) and frequencies of outcome indicators. A univariate difference-in-difference analytical approach will be used to estimate the effect of the interventions. In addition, a Blinder-Oaxaca decomposition analysis will be conducted to identify and quantify determinants of the modern contraceptive prevalence rate.

RESULTS

The intervention phase began in July 2021 and will run until June 2022. The impact assessment will be conducted from July to September 2022.

CONCLUSIONS

This project will evaluate the impact of integrating FP with MNCH services. Furthermore, this study will identify the drivers and barriers in uptake of MCMs and will simultaneously help in modifying the interventional strategies that can be scaled up through existing service delivery platforms within the public and private sectors, according to the local sociocultural and health system context.

CLINICALTRIAL

ClinicalTrials.gov NCT05045599; https://clinicaltrials.gov/ct2/show/NCT05045599

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/35291
Harnessing the electronic health care record to optimise patient safety in primary care: a framework for evaluating “electronic safety netting” tools (Preprint)
Authors: Black Georgia , Bhuiya Afsana , Friedemann-Smith Claire , Hirst Yasmin , Nicholson Brian D
Published: December 2021

UNSTRUCTURED

The management of diagnostic uncertainty is part of every primary care physician’s role. Electronic safety netting (e-safety-netting) tools help healthcare professionals to manage diagnostic uncertainty. Using software in addition to verbal and/or paper based safety-netting methods could make diagnostic delays and errors less likely. There are an increasing number of software products identifying as e-safety-netting tools, particularly since the COVID-19 pandemic. E-safety-netting tools can have a variety of functions including clinician alerts, administrative tasking, decision support and triggering reminder text messages to patients. However, these tools have not been evaluated using robust research designs for patient safety interventions. We present an emergent framework of criteria for effective e-safety netting tools, to support the development of software. The framework is based on validated frameworks from electronic health record development and patient safety. There are currently no tools available that meet all of the criteria in the framework. We hope the framework will stimulate clinical and public conversation about e-safety netting tools. In the future, a validated framework would drive audit and improvement. We outline key areas for future research, both in primary care and within integrated care systems.
Nutrition-Related Mobile Apps in the French App Stores: Assessment of Functionality and Quality (Preprint)
Authors: Martinon Prescilla , Saliasi Ina , Bourgeois Denis , Smentek Colette , Dussart Claude , Fraticelli Laurie , Carrouel Florence
Published: December 2021

BACKGROUND

The global burden of disease attributes 20% of deaths to poor nutrition. Although hundreds of nutrition-related mobile apps have been created, and these have been downloaded by millions of users, the effectiveness of these technologies on the adoption of healthy eating has had mixed

OBJECTIVE

The aim of this study was to review which nutrition-related mobile apps are currently available on the French market and assess their quality.

METHODS

We screened apps on the Google Play Store and the French Apple App Store, from March 10 to 17, 2021, to identify those related to nutritional health. A shortlist of 15 apps was identified, and each was assessed using the French version of the Mobile App Rating Scale: 8 dietitians and nutritionists assessed 7 apps, and the remaining apps were randomly allocated to ensure 4 assessments per app. Intraclass correlation was used to evaluate interrater agreement. Means and standard deviations of scores for each section and each item were calculated.

RESULTS

The top scores for overall quality were obtained by Yazio - Régime et Calories (mean 3.84, SD 0.32), FeelEat (mean 3.71, SD 0.47), and Bonne App (mean 3.65, SD 0.09). Engagement scores ranged from a mean of 1.95 (SD 0.5) for iEatBetter: Journal alimentaire to a mean of 3.85 (SD 0.44) for FeelEat. Functionality scores ranged from a mean of 2.25 (SD 0.54) for Naor to a mean of 4.25 (SD 0.46) for Yazio. Aesthetics scores ranged from a mean of 2.17 (SD 0.34) for Naor to a mean of 3.88 (SD 0.47) for Yazio. Information scores ranged from a mean of 2.38 (SD 0.60) for iEatBetter to a mean of 3.73 (SD 0.29) for Yazio. Subjective quality scores ranged from a mean of 1.13 (SD 0.25) for iEatBetter to a mean of 2.28 (SD 0.88) for Compteur de calories FatSecret. Specificity scores ranged from a mean of 1.38 (SD 0.64) for iEatBetter to a mean of 3.50 (SD 0.91) for FeelEat. The app-specific score was always lower than the subjective quality score, which was always lower than the quality score, which was lower than the rating from the iOS or Android app stores.

CONCLUSIONS

Although prevention and information messages in apps regarding nutritional habits are not scientifically verified before marketing, we found that app quality was good. Subjective quality and specificity were associated with lower ratings. Further investigations are needed to assess whether information from these apps is consistent with recommendations and to determine the long-term impacts of these apps on users.
Personality, Coping Strategy, and Quality of Life of Patients with Chronic Kidney Disease
Authors: Widjast Evlijn Pasha , Halim Magdalena S
Published: December 2021

Patients with chronic kidney disease are subject to prolonged medical treatment that might affect their quality of life. The purpose of this research was to investigate the correlation between personality, coping strategies, and quality of life in patients with chronic kidney disease. 40 Participants (25-55 years old) were recruited using purposive sampling and presented with three instruments: the Indonesian versions of NEO Personality Inventory-Revised (NEO PI-R), Ways of Copings, and Kidney Disease Quality of Life-36 (KDQOL-36). Results showed a significant correlation between all variables after regression analysis was applied. Further results indicate certain coping strategies were related to an individual’s perceptions of kidney disease. A significant correlation was found between three personality traits: neuroticism, extraversion and conscientiousness, and quality of life. Results also found that female patients have a better quality of life than men. Further research is needed to examine further the crucial role of social support and ethnic differences. Psychological intervention programs to provide psychoeducation on how to recognize stress symptoms and better stress management for patients with chronic kidney disease are also warranted.
The Content Analysis of Rorschach in Attesting the Sex Offenders
Authors: Hanum Lathifah , Megawati Alfath Hanifah , Dannisworo Cantyo Atindriyo , Hutahaean Bona Sardo Hasoloan , Poerwandari E. Kristi
Published: December 2021

The Rorschach test is one of the psychological tests widely used in various assessment settings, including in studies related to sexual offenses. However, such research is scarce, although the level of sexual violence in Indonesia increases yearly. Sexual violence is often associated with the sexual drives that humans have in themselves. In this case, Rorschach can provide an overview of the individual's drives, ideas, and social relationships. The current study aims to find the personality profiles of sex offenders. Therefore, this study collected Rorschach data from 46 male sex offenders over 11 years in Depok City, Indonesia. Based on content analysis, this study found several prominent characteristics of sex offenders, such as exhibited difficulties in adaptation due to low intellectual capacity, poor emotional regulation, and empathy that other causes difficulty to build strong relationships with others. They also suppress sexual urges, but they were more likely to express it impulsively with low intellectual capacity and emotional regulation. These various personality characteristics possessed by sex offenders will undoubtedly impact the intervention process they go through to gain insight from their experience. The results are expected to be an input for developing interventions for sex offenders not to repeat their actions in the future.
Obesidad/es: cuerpos, comidas y desigualdades
Authors: Salas Valenzuela Monserrat , Castañeda Salgado Martha Patricia
Published: December 2021

Reconociendo que frente al asunto de la obesidad, no existen consensos absolutos, seguimos preguntándonos de qué forma abordarlo sin dejar nada de lado, sin privilegiar solo un punto de vista, sin cerrar la mirada a tantos otros. De momento, decidimos ofrecer este número temático para que el conjunto de los textos permitan a quien los lea, ampliar su punto de vista, ojalá cuestionar los suyos propios y, sobre todo, contribuir a que la discusión no se acabe. En un intento por ordenar la conversación, enfatizaremos tres ejes, que en nuestra opinión atraviesan la problemática de la denominada obesidad, contribuyendo con preguntas y cuestionamientos, aunque sin ofrecer aún todas las respuestas.
La alimentación-salud de las mujeres en el campo mexicano del siglo XXI: desafíos para la soberanía alimentaria desde una mirada decolonial feminista
Authors: Vizcarra Bordi Ivonne
Published: December 2021

El objetivo del artículo es recapacitar sobre algunas problemáticas sociales sobre la alimentación, y los fenómenos de transición nutricional y epidemiológica (TAN-E) que confrontan las mujeres del campo mexicano ante el avance del dominio capitalista en los sistemas agroalimentarios.  Debido a la diversidad de contextos rurales que definen el campo mexicano, el escrito aborda una gran pregunta que guía la reflexión sobre los dilemas de tener acceso a los alimentos, alimentarse y alimentar sin poner en riesgo su salud: ¿la alimentación actual de las mujeres del campo mexicano compromete el resarcimiento de la soberanía alimentaria en términos del buen comer?  Para responderla, se eligió el problema del sobrepeso y obesidad asociado con la malnutrición registrado en multicasos situados alimentarios. A través de una mirada decolonial, se analizan las narrativas dominantes capitalistas que han producido conocimientos de este problema, fortaleciendo la mercantilización de los procesos de vida, lo cual complica la liberación del patriciado y su instrumentalización que someten a las mujeres rurales, indígenas, campesinas a nuevas relaciones de poder. Al reconocer estas relaciones en los mecanismos o instrumentos de la razón que explican la TAN-E y sus efectos en la salud de las mujeres, el artículo rescata elementos que pueden contribuir a la formación de masa crítica femenina, y con ella podría elaborarse una propuesta de rescate de la soberanía alimentaria en su justa dimensión ética, amigable con la naturaleza, y promotora de una cultura de cuidado y paz.
La obesidad: aspectos fisiopatológicos y clínicos
Authors: Kaufer-Horwitz Martha , Pérez Hernández Juan Fernando
Published: December 2021

La obesidad es una enfermedad crónica, recurrente, de etiología compleja caracterizada por un desequilibrio de energía debido a un estilo de vida sedentario, un consumo excesivo de energía, o ambos. Se desarrolla a partir de la interacción de factores genéticos, sociales, conductuales, psicológicos, metabólicos, celulares y moleculares. Se define como la acumulación anormal o excesiva de tejido adiposo en relación con el peso que puede ser perjudicial para la salud. Es factor de riesgo de enfermedades crónicas como diabetes mellitus tipo 2, enfermedades cardiovasculares y algunos cánceres y tiene repercusiones biológicas, psicológicas y sociales. Afecta, aunque de manera diferencial, a ambos sexos y a todos los grupos socioeconómicos y de edad. Su prevalencia, tanto a escala mundial como en México, se ha incrementado en los últimos treinta años. Su tratamiento debe ser multidisciplinario siendo el componente central el cambio en el estilo de vida (alimentación y actividad física). En algunos casos la prescripción de fármacos puede ser necesaria como coadyuvante al tratamiento y en casos de obesidad extrema la cirugía bariátrica es la opción más efectiva y se asocia con mejoría metabólica. El presente documento se concentra en el abordaje de los aspectos fisiopatológicos y clínicos más relevantes.
Bulimia nervosa: Assessment instruments for Spanish-speaking population / Bulimia nerviosa: Instrumentos de evaluación para población de habla hispana
Authors: Bautista-Díaz María Leticia , Amaya-Hernández Adriana , Ortega-Luyando Mayaro , Ortega-Andrade Norma Angélica
Published: December 2021

De la población mundial 7.8% es hispanohablante, esto representa 567 millones de personas y se calcula que para 2050 esta cifra se elevará, además, el español es el segundo idioma de comunicación a nivel internacional; con este contexto y a casi cuatro décadas de la aparición formal de la Bulimia Nerviosa (BN), es necesario conocer cuáles y cómo son los instrumentos para evaluar los síntomas de la BN en este tipo de población. Por tanto, el objetivo de la presente investigación fue describir los cuestionarios para evaluar en población de habla hispana los síntomas de BN.  Se encontró que México, cuenta con seis instrumentos; España con cinco; Colombia tiene tres instrumentos; Puerto Rico y Cuba cuentan con dos; Argentina, Costa Rica, Bolivia, El Salvador, Venezuela y República Dominicana, cuentan con uno. Estos pueden ser para el tamizaje de síntomas de la BN; o para evaluar los síntomas de la BN como parte de la evaluación de diversas dimensiones; o para evaluar a los familiares/cuidadores en el proceso de tratamiento de la BN. Se concluye que, es alentador que la población de habla hispana cuente con diversos cuestionarios adaptados y validados en su lengua para evaluar los síntomas de la BN.
Presentación
Authors: Franco-Paredes Karina
Published: December 2021

El presente número de la Revista Mexicana de Trastornos Alimentarios/Mexican Journal of Eating Disorders tiene el propósito de presentar un análisis sobre las evidencias de confiabilidad y validez de las puntuaciones de los instrumentos de medida utilizados en la investigación y tratamiento de los trastornos de la conducta alimentaria y de la ingestión de alimentos (TAIA) en población hispano hablante. Para cumplir con este propósito el número está conformado por nueve revisiones narrativas sobre las propiedades psicométricas de los instrumentos más utilizados en este campo de estudio con la colaboración de autores de cinco países, España, Argentina, Chile, Estados Unidos y México.La medición es uno de los pilares en los que se sustenta el avance de una área de estudio. El nivel de precisión y validez de las puntuaciones de los instrumentos utilizados para medir las variables está relacionado con la fortaleza de las conclusiones. En el campo de los TAIA desde hace más de cuatro décadas se han desarrollado instrumentos siguiendo procesos rigurosos de construcción y evaluación permanente de su calidad métrica. Algunos instrumentos han sido revisados considerando los cambios en los criterios de diagnóstico de acuerdo con el Manual Diagnóstico y Estadístico de los Trastornos Mentales (DMS, por sus siglas en inglés). Se ha demostrado que son vigentes para la evaluación tanto de los síntomas como de las variables asociadas a estos trastornos y en algunos casos se ha evidenciado que es necesario realizar adaptaciones.Agradezco la colaboración de quienes contribuyeron en cada una de las nueve revisiones que conforman este número monográfico.  Un agradecimiento especial a la Dra. Carme Viladrich, experta en psicometría, quien aceptó la invitación para escribir la editorial de este número. Sus aportaciones en el área de la psicometría y su interés por mejorar la evaluación de la calidad de las puntuaciones de los instrumentos de medida han inspirado la propuesta de este número monográfico. La rigurosidad de su análisis y honestidad intelectual han sido una guía importante para la realización de estudios instrumentales. Espero que el contenido de este número monográfico sirva para difundir el conocimiento sobre cómo fueron construidos los instrumentos y cómo se ha generado evidencia respecto a la validez y confiabilidad de sus puntuaciones en población hispano hablante. Así, los profesionales e investigadores podrán decidir sobre la utilización de un instrumento basándose en la evidencia empírica sobre su calidad métrica. Sin duda, también se tienen grandes áreas de oportunidad para continuar generando evidencia respecto a los instrumentos en esta área de estudio. Es necesario realizar una evaluación continua de las propiedades psicométricas incorporando los avances en el análisis de datos.
Improving Hybrid Power Supply System for Telecommunication Service Providers in Nigeria
Authors: O. C. Odudu
Published: December 2021

Abstract: The aim of this research is to use a combination of renewable energy sources and conventional diesel generator to model a cost effective, alternative energy source for telecommunication base stations in Nigeria. Actually, this study uses various theoretical and mathematical modelling tools, such as, Mat lab Simulink and HOMER software. In the same way, the study references several Base Transceiver Stations (BTS) from gsm providers at select geographical locations in Rivers State. The study references BTS infrastructure in locations such as Ogoni, Port Harcourt and Emohua. These locations were selected to reflect different climatic conditions in Rivers state. Against this background, various hybrid combinations comprising at least two sources of renewable energy e.g Wind Turbine generator(WTG) and Solar Photovoltaic (SPV) were modelled. Also, Fuzzy logic optimization algorithm was used in tracking the maximum power in the SPV. A sample Diesel Generator(DG) was studied to analyze which possible combination gives optimum performance and is most cost effective. The total cost for installation and maintenance of the hybrid system was also considered. Consequently, one of the common negative effects of conventional power generation and usage, which is environmental pollution, was also highlighted during the study. In the course of this research, Homer was used to model a hybrid system in which the initial capital Cost (ICC) was N101,517,040 for 96 nos battery, 1 no 10kw WTG, 1 no hydro-turbine, 48 nos converters, labour etc. The replacement cost for component has a depreciation of 30%; while maintenance for diesel is 30% of the ICC. Eventually, the results obtained from the simulations showed that with an increase in supply from renewable energy sources the overall cost spent when compared to using a diesel generator only is cut by 50%, while the pollution effects also dropped. In fact, the cost also reduces if the renewable energy system is designed efficiently to track and harness maximum power. Furthermore, it is also evident that the location of the base station site and the availability of Renewable energy source affects the efficiency and cost of the entire system. Hence, it is recommended that any telecommunication company which intends installing a hybrid power system for its base stations must carry out detailed feasibility studies using input parameters described here; especially, as it relates to siting of base stations in rural off-grid areas. Keywords: Hybrid Power Supply System
Analysis Effects of Average Value of Convective and Evaporative Heat Transfer Coefficient on Solar Cabinet Dryer for Reduction of Mass of Papad
Authors: Mathuriya Goldi
Published: December 2021

Abstract: In this research paper, the behavior of heat and mass transfer phenomenon during greenhouse papad drying under forced convection mode has been investigated. Various experiments were performed during the month of April 2020 at SRCEM Banmore, morena (26o 34’13” N 78o 10’48” E). Experimental data obtained for forced convection greenhouse drying of papad were used to determine the constants in the Nusselt number expression by using the simple linear regression analysis and, consequently, the values of convective and evaporative heat transfer coefficients were evaluated. The average values of experimental constants C and n were determined as 0.9714 and 0.0129 respectively. The average values of convective and evaporative heat transfer coefficients were determined as 0.0886 W/m2 oC and 6.7583 W/m2 oC respectively. The experimental error in terms of percentage uncertainty was also evaluated. Keywords: Papad, Papad drying, Heat transfer coefficient, Convective, Evaporative, Forced convection greenhouse
Populisme dan Dinamika Otoritas Keagamaan dalam Islam di Media Sosial
Authors: Muhammad Nur Afni
Published: December 2021

The research is used to answer three main problems, namely what are the discourses behind Felix Siauww's appearance on social media such as YouTube and Instagram, how is the narrative of Islamic Populism discourse built by Felix Siauww on Instagram, and how YouTube media builds and strengthens Felix Siauww's religious authority. The researcher used the visual ethnographic method offered by Cristine. Data collection is done by combining empirical and theoretical data that is devoted to social media which is devoted to Felix Siauww's Instagram account and YouTube Channel. The results of Felix Siauww's research maximize the sophistication of social media, namely by paying attention to aspects of ethical values, character, and aesthetics. There are three reasons to mention Felix Siauww as a representation of Islamic populism among Netizens; First, Islamic populism is synonymous with anti-establishment terminology. second, Islamic populism is synonymous with anti-authoritarian narratives, third, populism contains narratives of religious purification and calls for a return to true teachings.