bluuebunny/crossref_metadata_2025 huggingface dataset:
Tuina (Chinese massage) for insulin resistance and sensitivity: A protocol for systematic review and meta-analysis of animal and human studies
Authors: Zhao Zhixuan , Yan Jun , Ding Yuxin , Wang Yingji , Li Yan
Published: July 2023

Introduction

Insulin resistance (IR) could be regarded as a therapeutic target for metabolic diseases. Therefore, multiple therapeutic strategies that target IR should be applied to provide a more effective means of treatment. It aims to determine Tuina’s efficacy and safety for IR through this systematic review and meta-analysis.

Methods

From the inception to July 31, 2023, we will search four English databases (Pubmed, Embase, Cochrane Central Register of Controlled Trials, Web of Science) and two Chinese databases (China National Knowledge Infrastructure and the Chinese Science and Technology Periodical Database). We will search and include studies of both human and animal models that evaluate Tuina’s effects on insulin sensitivity or resistance. Data selection, data extraction, and risk of bias assessment will be made by two independent reviewers. We will evaluate the methodological quality of all included studies and conduct meta-analyses using Review Manager Software 5.4.1.

Discussion

In both animal and human studies, the effects and safety of Tuina for IR will be evaluated. The evidence generated bythis study will validate effects and safety of Tuinain treating IR and inform future research and clinical decision-making.

Trail registration

PROSPERO Registration ID:CRD42022360128.
Offline EEG hyper-scanning using anonymous walk embeddings in tacit coordination games
Authors: Zuckerman Inon , Mizrahi Dor , Laufer Ilan
Published: July 2023

In this paper we present a method to examine the synchrony between brains without the need to carry out simultaneous recordings of EEG signals from two people which is the essence of hyper-scanning studies. We used anonymous random walks to spatially encode the entire graph structure without relying on data at the level of individual nodes. Anonymous random walks enabled us to encapsulate the structure of a graph regardless of the specific node labels. That is, random walks that visited different nodes in the same sequence resulted in the same anonymous walk encoding. We have analyzed the EEG data offline and matched each possible pair of players from the entire pool of players that performed a series of tacit coordination games. Specifically, we compared between two network patterns associated with each possible pair of players. By using classification performed on the spatial distance between each pair of individual brain patterns, analyzed by the random walk algorithm, we tried to predict whether each possible pair of players has managed to converge on the same solution in each tacit coordination game. Specifically, the distance between a pair of vector embeddings, each associated with one of the players, was used as input for a classification model for the purpose of predicting whether the two corresponding players have managed to achieve successful coordination. Our model reached a classification accuracy of ~85%.
Érdemes-e stratégiai célokat kitűzni? : A stratégiaalkotás és megvalósítás korlátai és lehetősége
Authors: Csendes István , Bocskor Ákos
Published: July 2023

A hosszú távú stratégiai célok kijelölése, illetve az ezek elérését megcélzó stratégia megvalósítása napjainkban érvényes koncepcióknak tekinthetők? A szerzők válaszuk megfogalmazásához szakirodalomi áttekintést végeztek, amely alapvetően a stratégiaalkotás előíró modelljeinek problémáira, illetve részben a nem előíró lehetőségeire fókuszál. Megállapítják, hogy a legújabb kutatási eredmények alapján a stratégiaalkotás és megvalósítás nem idejétmúlt koncepciók: Hiszen 1) az előre kitűzött stratégia megvalósítása észszerű szervezeti cselekvésként értelmezhető. 2) A kitűzött stratégiák bukási arányának vizsgálata nem cáfolja az előíró gondolkodásmód érvényességét. 3) A stratégia (tervezés és megvalósítás), valamint a szervezeti teljesítmény között mérsékelt pozitív kapcsolat figyelhető meg. Mindeközben arra is fényt derült, hogy 4) a stratégia megvalósítása változót a kutatók ezideáig nem kezelték jelentőségéhez mérten megfelelően. Végül a stratégiaalkotás jelenével és jövőbeli lehetőségeivel foglalkozva, röviden kiemelnek néhány kortárs megközelítést, mint a foresight, vagy a fizika tudományából ismert elvek (káosz, entrópia), továbbá az adatvezéreltség és a „big data” elemzések stratégiai alkalmazását, vagy az ún. „formáló” (shaping) vállalatok megjelenését.
Universidades Federais Brasileiras com Vagas para Refugiados
Authors: Magri Moreira de Carvalho Victória , Ranuzzi Luiza Aparecida , Lucchett Silva Pedro , Cardoso Squeff Tatiana , Gonçalves Paluma Rocha Thiago
Published: July 2023

Esta pesquisa busca determinar quais universidades federais possuem vagas específicas para pessoas refugiadas e compreender as especificidades de seus editais. A partir de um contato inicial com as universidades e uma pesquisa baseada em uma metodologia documental e analítica, foi feita uma lista de universidades brasileiras que oferecem vagas aos refugiados e, também, seus requisitos comuns. Para tanto foram utilizados os editais divulgados pelas próprias universidades tanto quanto documentos jurídicos que positivavam tais ações afirmativas dentro dos ordenamentos internos destas instituições Também foram analisadas as universidades que apresentam propostas que ainda não foram postas em ação, e mais profundamente os tipos de ações tomadas por aquelas que praticam um edital mais inclusivo aos refugiados.
THE RELATION BETWEEN EARTHQUAKES AND VOLCANOES IN THE SEA EDGE OF THE SOUTH MIDDLE OF VIETNAM IN THE LAST YEARS
Authors: Thuc Pham Van
Published: July 2023

Eanhquake and volcano are two phenomenons of one geological process. They have a close relation and  both are link with deep tectonic faul zones. From June 2005 up to now a series of eaquakes with magnitude from 2.2 to 4.8 have occurred in the shell zone of South of Central Vietnam. They shook many region of which Ho Chi Minh city. The caution is that: these earthquakes occurred at the same area, where group of active volcanoes are locured. At this area Hon Tro volcano group have empled several times, in 1880 - 1882, 1923 and later in 1928,  1978. The 1923 eruplion was most significant. It was well examined by scientists. The results of research  show that the heat flow there is high and reaches 335 mw/m2. The area is situated at the tectonic weak zone,  which cross cut by fault of Longitude 1090E and NE-SW tectonic faults. This situation makes the zone  sensible for eanhquake and volcano. According to scientific  judgments the South of Central Vietnam coastal zone could suffer from earthquakes  of magnitudes M=5.5  maximum, intensity of VII. In the future the maximum magnitudes and intensity in  this region will not be larger than above level, however volcano like Hon Tro in 1923 can take place.
A Estratégia de Intercooperação de Redes Empresariais: uma Análise dos Fatores Preditores
Authors: Wegner Douglas , Oliveira de Almeida Matheus , Bitencourt Fortes Marcos Vinícius , Freitag Dallagnol Mathäus Marcelo
Published: July 2023

O estudo teve como objetivo analisar os fatores preditores na intenção de redes empresariais em adotar uma estratégia de crescimento através da intercooperação. A pesquisa adotou a abordagem quantitativa, por meio de uma survey com 156 associados de redes empresariais e analisou os dados por meio de regressão linear múltipla. A estratégia de intercooperação em redes empresariais emerge como estratégia de crescimento onde a complementariedade das redes auxilia a obtenção de objetivos comuns, além de manter as redes atrativas para seus participantes, bem como a novos associados. Estudos anteriores já identificaram benefícios da intercooperação, entretanto resta investigar os fatores antecedentes desta estratégia interorganizacional. Os resultados demonstram que os antecedentes da intercooperação se originam de motivações estratégicas, gerenciais, culturais e ambiental-institucional, sendo também o número de associados da rede fatores que influenciam decisões futuras de intercooperar. O estudo apresenta contribuições gerenciais e teóricas a respeito da identificação dos fatores propulsores e restritivos e suas dimensões, além do impacto destes na intenção das redes empresariais em adotar estratégias de crescimento por meio da intercooperação.
Digital Disconnection and Portuguese Youth: Motivations, Strategies, and Well-Being Outcomes
Authors: Dias Patrícia , Martinho Leonor , Jorge Ana
Published: July 2023

As most individuals become digital media users, many struggle to find balance in such use. This study adds to emergent research on how digital disconnection experiences reflect on well-being (Nguyen et al., 2021; Radtke et al., 2022; Vanden Abeele, 2021) by focusing on motivations and strategies to disconnect from digital media, as well as on outcomes for well-being. We set out to understand teenagers who have voluntarily chosen to disconnect in the post-lockdown period in 2021. Our qualitative study included 20 participants from Portugal between 15 and 18 years old. Among those who consciously chose to disconnect from digital media, motivations arose from realizing that digital media was not bringing enough benefits for the amount of time that they took from users. Specific forms of digital media stood out as particularly problematic for young people, especially social media, but also videogames and pornography. This realization seems to be strongly influenced by the media and is evident in the vocabulary and associations used by our respondents. Social pressure is felt both as causing anxiety when they are connected and when they are disconnected through fear of missing out. However, the group provides support when they engage in a progressive disconnection together. Radical disconnection is rare, especially during the pandemic, and can appear as a solution to a dramatic problem in young people’s lives, but it can also be reverted. More often, participants attempted to self-regulate their use of digital when they acknowledged the advantages of those services as well as their drawbacks. This is not a linear process but rather filled with attempts and reversals as unexpected feelings such as boredom arise. When young people grow different leisure and social habits, they experience positive outcomes of disconnecting from the digital.
Development in the Machine Learning Algorithm for the Treatment of Open Boundary Conditions in Smoothed Particle Hydrodynamics GPU Models
Authors: Verma Deepak
Published: July 2023

Smoothed Particle Hydrodynamics (SPH) is a powerful computational method used for simulating fluid dynamics and related phenomena. One of the challenges in SPH simulations is the treatment of open boundary conditions, which are common in many real-world scenarios. Traditional approaches to handling open boundaries in SPH models involve the use of artificial boundaries or ghost particles, which can introduce inaccuracies and computational overhead. Significant advancements have been made in the application of machine learning algorithms to address the open boundary condition problem in SPH simulations. This approach leverages the power of modern Graphics Processing Units (GPUs) to accelerate the training and deployment of these algorithms. Machine learning algorithms have shown promise in accurately predicting fluid behavior near open boundaries while minimizing computational costs. This presents a comprehensive review of the latest developments in machine learning algorithms for the treatment of open boundary conditions in SPH GPU models. We discuss the key challenges associated with open boundaries in SPH simulations and how machine learning can provide efficient and accurate solutions. Various techniques, including neural networks, convolutional neural networks, and recurrent neural networks, are explored in the context of SPH simulations.  We highlight the advantages and limitations of different machine learning approaches and discuss the importance of appropriate training data and optimization strategies. The integration of machine learning algorithms with SPH simulations offers the potential to significantly enhance the accuracy and efficiency of open boundary treatments, enabling more realistic modeling of fluid dynamics in complex scenarios. We present several case studies and benchmarks that demonstrate the effectiveness of machine learning algorithms in improving open boundary conditions in SPH GPU models. We discuss the computational performance gains achieved by leveraging GPU acceleration and provide insights into the potential future directions for further research and development in this field.
Methods of Functional Safety Analysis for Cyber Physical Systems Integrated Circuits
Authors: Garg Umang
Published: July 2023

Integrated circuits (ICs) are used in a wide variety of real-world systems. Interacting ICs (also known as cyber-physical systems or hybrid systems) with physical systems is a common component of many real-world systems used for safety-critical applications. Potentially catastrophic results from even a minor breakdown in any component of the system need cautious deliberation before any action is performed. Safety analysis of integrated circuits is becoming more important as a growing number of systems depend on ICs to meet the functional requirements of safety-critical applications. There has been a shift away from the old method of creating cyber-physical systems, whereby both the digital and physical elements were created separately. In this work, we compile a variety of approaches for efficiently and affordably satisfying functional safety standards at the level of the application.
Management of Multidrug-resistant Tuberculosis in a Ukrainian Refugee with HIV/HCV Coinfection: A Case Report
Authors: Russu Kristina ,   Department of Internal Medicine I, University Hospital of Bonn, Bonn, Germany,   These authors contributed equally., Schlabe Stefan ,   Department of Internal Medicine I, University Hospital of Bonn, Bonn, Germany,   German Center for Infection Research, Partner-site Bonn-Colone, Cologne, Germany,   These authors contributed equally., Kütting Daniel ,   Department of Radiology, University Hospital of Bonn, Bonn, Germany, Rieke Gereon ,   Department of Internal Medicine I, University Hospital of Bonn, Bonn, Germany,   German Center for Infection Research, Partner-site Bonn-Colone, Cologne, Germany, Schäfer Vera ,   Department of Internal Medicine I, University Hospital of Bonn, Bonn, Germany, Klein Ulrich ,   Lung Hospital Hemer, German Community Diakonie Association (Deutscher Gemeinschafts-Diakonieverband [DGD] GmbH), Hemer, Germany, Lange Christoph ,   Research Center Borstel, Leibniz Lung Center, Borstel, Germany,   Tuberculosis Unit, German Center for Infection Research, Borstel, Germany,   Respiratory Medicine & International Health, University Lübeck, Lübeck, Germany,   Baylor College of Medicine and Texas Children´s Hospital, Global TB Program, Houston, TX, USA, Boesecke Christoph ,   Department of Internal Medicine I, University Hospital of Bonn, Bonn, Germany,   German Center for Infection Research, Partner-site Bonn-Colone, Cologne, Germany
Published: July 2023

In this case study, we present a 53-year-old Ukrainian refugee with reactivation of multidrug-resistant tuberculosis, which was treated in Ukraine 4 years before he fled the country following the Russian invasion of Ukraine. The patient had a chronic HIV infection that had been treated with antiretroviral therapy and was newly diagnosed with severe acute respiratory syndrome coronavirus 2019 infection, hepatitis C infection and liver cirrhosis. Therefore, tuberculostatic therapy was individualized because of resistance against rifampicin, isoniazid, bedaquiline, and clofazimine and pre-existing liver cirrhosis and neuropathy. The latter was a sequela of a former tuberculosis treatment taken 4 years earlier. The treatment of the patient was complicated by superinfection of the lung cavity with carbapenemase-resistant Klebsiella pneumoniae and a life-threatening massive haemoptysis. He received a selective angiographic examination and bronchial artery embolization. This case report illustrates the complex management of several coinfections in the context of a humanitarian crisis following the on-going military conflict in Ukraine.
Чего ждать от фигурного катания в России в 2023 году: упадка или достижения нового уровня
Authors: Ибрагимов И.Ф. , Тазтдинова О.Ю.
Published: July 2023

В этой статье приводятся результаты собственного исследования, проведенного среди жителей Татарстана в 2023 году, целью которого является получение ответа на вопрос: Что ждет фигурное катание в России в 2023 году? Рассматриваются возможные варианты развития данного вида спорта в стране, а также проблемы, с которыми столкнулись российские спортсмены.
Актуальные проблемы адаптивной физической культуры
Authors: Карпов Р.В. , Хабибуллин А.Б.
Published: July 2023

В современном мире существует значительное количество людей с ограниченными возможностями, и, к сожалению, ежегодно их количество увеличивается. Но это не значит, что лица с ограниченными возможностями не могут заниматься физической культурой и спортом. Потребность решения проблемы недостатка физической нагрузки у лиц с ограниченными возможностями заложило формирование нового ответвления физической культуры, а именно, создание адаптивной физической культуры. В данной статье рассматриваются проблемы адаптивной физической культуры, которая способствует укреплению здоровья.
Records Management in Judicial Councils in Constituent Entities of the Russian Federation (within the Framework of Assurance of Safekeeping of Documents on Their Activities in the Archive Fund of the Russian Federation)
Authors:   Associate Professor of the Department of Civil Procedure Law of the Northwestern Branch of the Russian State University of Justice, PhD (Law), Latysheva Natalya A.
Published: July 2023

The councils of judges in the constituent entities of the Russian Federation, as well as the general meetings of judges of individual courts, being the bodies of the judicial community, conduct their own documents management systems. The insufficiency of regulation in the field of paperwork of these bodies forms uncertainty in the matters of recruiting their archival collections. This article has made an attempt to develop prospects for improving activities to maintain information about the work of the Soviets of judges of the constituent entities of the Russian Federation as part of the Archival Fund of the Russian Federation.
Compulsory Heterosexuality and Lesbian Invisibility in Nursing
Authors: Searle Jennifer
Published: July 2023

Lesbian nurses have historically been silenced, but diversity initiatives within professional health programs suggest a need to initiate scholarly discussions that explore heteronormativity as increasing the risk of harm for nonheterosexual nurses as compared to their heterosexual counterparts. Nurses can reflect on relative privilege within the profession to better understand the ways in which normative health practices perpetuate adverse health outcomes among vulnerable patient populations. Nurses from diverse backgrounds, such as this lesbian author, offer insight into how the nursing profession might illuminate relational aspects of privilege. As such, the nursing profession could uncover solutions to systemic vulnerabilities which are inadvertently perpetuated within our profession, the health-care system, and society more broadly. The notion of compulsory heterosexuality is discussed in relation to nursing in this opinion piece with an aim to render structural harms visible that have been obscured by the institutionalization of heteronormativity in health care, to build awareness of the ways in which systemic vulnerabilities are unknowingly perpetuated despite health-care professionals being well-intended in their practice.
Design Thinking like a Nurse: A Professional Practice Model for Nursing Innovation
Authors: Koppel Paula D. , Sullivan Shanna D.
Published: July 2023

The COVID-19 pandemic made creative problem-solving, a skill that nurses have long possessed, more observable and valued. This article presents a new professional practice model for nursing innovation that facilitates practice improvements and leverages skills, strengths, and values that are integral to nursing. This model integrates the nursing process with Design Thinking and Theory U change management processes. A clinical case study illustrates the model's components in a pediatric oncology ambulatory center. Using this practice model, nurse leaders can leverage “design thinking like a nurse,” to enhance innovation in health-care settings.
Seeing beyond Traditional Measurement: Recognizing the Value of the Experience of the Place, the People, and Their Work
Authors: Martin Bobbi , Balwanaki Chris Anold
Published: July 2023

Seeing beyond traditional measurement means knowing the story behind the outcome. It means recognizing the value of the experience of the place, the people, and their work. The global community recognizes the crucial need to end preventable child deaths, making it an essential part of the Global Strategy for Women, Children, and Adolescent Health (2016–2030) and the third Sustainable Development Goal to ensure healthy lives and promote wellbeing for all people at all ages (World Health Organization, 2019). This article shares statistically significant results of a nursing training initiative at Whispers Magical Children's Hospital (WMCH) in Jinja, Uganda, in sub-Saharan Africa where the region persists with the highest under-five mortality rate in the world. But the richer data yield can be found in the experiences of two in-country visits. Finding ways to create educational efforts for nurses in underserved geographical areas is critical to the improvement of the health status of their communities. Bringing health technology to these areas will improve the delivery of high-quality, evidence-based care by nurses, with a direct effect of positively influencing the health status of women, children, and communities.
Tenei au te koronga: Growing Māori postgraduate research excellence
Authors:   Te Koronga Māori Research, Cunningham Chelsea , Mita Ngahuia , Raureti Terina , Hanara Ben , Burton Tasha , Ratahi Rawiri , Skelton Te Kahurangi , Parata Nick
Published: July 2023

Te Koronga is a Māori research excellence rōpū that Professor Anne-Marie Jackson and Dr Hauiti Hakopa founded at the University of Otago. The year 2023 marks the 10th anniversary of Te Koronga. Over the past 10 years, Te Koronga has been successfully supporting and producing excellent Māori researchers. A collective of current Te Koronga tauira, many of whom have contributed to other articles in this issue, have written this concluding article of the Te Koronga MAI Special Issue. We are unapologetically proud to be Te Koronga. Why?
Changes in primary and secondary hemostasis as a predictor of adverse neonatal outcomes in birth asphyxia
Authors:   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Kondratiev M.V. ,   Moscow Regional Perinatal Center, Ministry of Health of the Moscow Region, Balashikha, Russian Federation, Petrova A.S. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation,   Moscow Regional Perinatal Center, Ministry of Health of the Moscow Region, Balashikha, Russian Federation, Gryzunova A.S. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation,   Moscow Regional Perinatal Center, Ministry of Health of the Moscow Region, Balashikha, Russian Federation, Lavrentiev S.N. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation,   Moscow Regional Perinatal Center, Ministry of Health of the Moscow Region, Balashikha, Russian Federation, Zakharova N.I. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Serova O.F. ,   Moscow Regional Perinatal Center, Ministry of Health of the Moscow Region, Balashikha, Russian Federation, Krasnova V.A. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation,   Moscow Regional Perinatal Center, Ministry of Health of the Moscow Region, Balashikha, Russian Federation, Zhybanisheva K.B. ,   Kazakh-Russian Medical University, Almaty, Kazakhstan
Published: July 2023

The hemostatic system is complex and evolves continuously since gestation and well into the adult years, in a process known as “developmental hemostasis”. This article presents information about the functioning of the hemostatic system in normal and pathological conditions (birth asphyxia) in newborns, reflects fundamental differences in hemostatic functioning during the neonatal period and the possibilities in maintaining normal hemostasis in conditions of physiological deficiency of both clotting factors and the anticoagulant system. The article highlights various methods of diagnosing the hemostatic system used in neonatology. The so-called global hemostasis tests are being introduced into neonatal practice. The study of hemostasis using thromboelastography technique allows to correct for the patient's real body temperature and estimate both the interaction of platelets and clotting factors and examine the plasma hemostasis component in isolation. The effects of neonatal asphyxia and therapeutic hypothermia procedures on the hemostatic system are poorly understood. This review article attempts to summarize the data available in the world scientific literature concerning this problem. Key words: newborns, developing hemostasis, asphyxia, hypoxic-ischemic encephalopathy, thromboelastography, coagulation, therapeutic hypothermia
Bioimpedance analysis (BIA) of body composition in patients with cystic fibrosis
Authors:   Research Centre for Medical Genetics, Moscow, Russian Federation, Maksimycheva T.Yu. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Kondratyeva E.I. ,   Research Centre for Medical Genetics, Moscow, Russian Federation,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation
Published: July 2023

Nutritional status is associated to lung function and survival. Body mass index (BMI) is used to determine nutritional status, last studies of the body composition show that the most informative indicators correlated with lung function are data about body composition, the ratio of fat and fat-free body mass. In Russian Federation the body composition of children with cystic fibrosis is poorly studied. Objective. To assess the body composition before starting targeted therapy in children with cystic fibrosis Patients and methods. 103 children aged 5 to 17 years were examined. The median age of the children is 12 ± 5 years. Male – 47 (45.6%), female – 53 (53%). The children were divided into 3 groups: 1 group – BMI ≥50 percentile, 2 group – BMI <50 > 10 percentile, 3 group – BMI ≤10 percentile. In the studied groups were analysed: anthropometric indicators, nutritional status, bioelectrical impedance analysis (BIA), external respiration function. Cross-sectional study design. Conclusion. Patients with cystic fibrosis may have high risk of developing sarcopenia with normal level of BMI ( progressive and generalised skeletal muscle disorder involving the accelerated loss of muscle mass and function ). Measurement of body composition, including data of the lean body mass ratio, insufficiency of the protein in the diet and the entire energy metabolism, will improve the nutritional status of children, reduce the risk of respiratory and metabolic complications in patients with cystic fibrosis. Kewords: bioimpedance, body composition, children, cystic fibrosis, metabolism, fat-free body weight, body fat mass, body mass cell, phase angle
Features of physical development and nutritional status of children with Crohn disease
Authors:   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Khavkin A.I. , Zavyalova A.N. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Novikova V.P. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Yablokova E.A. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Churakovа I.Yu. ,   National Research University Higher School of Economics (HSE), Saint Petersburg, Russian Federation, Yakovleva M.N. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Erokhina M.I. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Chibrina E.V. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Lisovskaya E.O. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation
Published: July 2023

Objective. Any severe chronic disease affects the physical development and nutritional status of the child. In Crohn's disease, this effect is complex, because. the gastrointestinal tract is involved in the pathological process, the absorption of nutrients is impaired, and more often the losses exceed the intake of basic nutrients and energy. Patients and methods. In a single-center observational study in the gastroenterology department of a multidisciplinary pediatric hospital, anthropometry data were evaluated in 94 patients (44.7% boys, 55.3% girls) aged 3 to 17 years (mean age 7 years) with a verified diagnosis of Crohn's disease, receiving treatment. Children are divided into age groups according to the WHO classification. Assessment of physical development (height, weight, BMI) was carried out according to the WHO Anthro and WHO AnthroPlus programs. Statistical processing of the material was carried out using the IBM Stata 12 application software package. The hypothesis of normal distribution was tested using the Shapiro–Wilk and Kolmogorov–Smirnov tests. In order to detect differences between the samples, the Kruskall–Wallis test was used; for a posterior comparisons, the Bonferroni correction was used. Results. Most often, children with this diagnosis seek specialized medical care in the period of second childhood (n = 25), adolescence (n = 44) and late adolescence (n = 17). There is a shift in the Z-score of growth to the zone of low values in the groups of the first and second childhood. Among patients of adolescence and youth, there are children with medium and high growth. Body weight deficiency was found in children of the first and second childhood. Deficient BMI is more common in children of adolescence and youth, at the same time, obesity occurs among these patients, but much less frequently than in the general population. Key words: BMI, сhildren, Crohn's disease, physical development
Iatrogenic Cushing’s syndrome post intralesional triamcinolone acetonide in Oral submucous fibrosis: 2 case reports
Authors: Choden Kuenga , Gyeltshen Tshewang
Published: July 2023

Background:
Oral Submucous Fibrosis is a premalignant condition that is strongly linked to betel quid chewing. It exhibits a significantly higher rate of malignant transformation compared to other premalignant lesions. Fortunately, the use of Intralesional Triamcinolone Acetonide Injection has emerged as a highly effective treatment option and has become the cornerstone of managing this condition. Case Presentation: A 44-year-old female and a 40-year-old male presented with burning sensation and limited mouth opening, leading to a diagnosis of Oral Submucous Fibrosis. Both patients underwent treatment with Triamcinolone Acetonide Intralesional injections. Following a few months of treatment, a significant improvement in mouth opening was observed. However, both patients began experiencing symptoms such as facial rounding (mooning of the face), a buffalo hump, uneven hair growth, and swelling in the lower extremities. Upon recognizing these symptoms as indicative of Cushing's Syndrome, the administration of Triamcinolone Acetonide injections was discontinued. Both patients were referred to a higher-level medical facility for confirmatory tests, which revealed elevated cortisol levels in both morning (Cortisol A.M) and evening (Cortisol P.M).
Conclusion:
Triamcinolone Acetonide has been reported as an effective treatment for OSF. However, it is crucial to closely monitor patients for any adverse effects resulting from the treatment, which may arise from high dosage or increased frequency.
The Mediating Role of Perceived Social Support in the Effect of the CALM Intervention on Quality of Life in Patients Following Breast Cancer Surgery
Authors: Liu Shaochun , Chai Jiaying , Jia Yingxue , Yao Senbang , Ge Han , Huang Runze , Li Anlong , Cheng Huaidong
Published: July 2023

Objective Despite numerous studies demonstrating the positive effects of psychological interventions on psychological resilience and quality of life in postoperative breast cancer patients, the specific contribution of perceived social support to these outcomes remains uncertain. This study aimed to investigate the impact of the Managing Cancer and Living Meaningfully (CALM) intervention on these outcomes and explore the potential mediating role of perceived social support.
Methods A total of 124 adult breast cancer patients were randomly assigned to the intervention group (IG, n = 62) or the control group (CG, n = 62). Baseline and three follow-up assessments were conducted to measure psychological resilience, quality of life, anxiety, depression, and perceived social support. Data were analyzed using mixed linear models and structural equation modeling.
Results A total of 124 adult breast cancer patients were randomly assigned to the intervention group (IG, n = 62) or the control group (CG, n = 62). Baseline and three follow-up assessments were conducted to measure psychological resilience, quality of life, anxiety, depression, and perceived social support. Data were analyzed using mixed linear models and structural equation modeling.
Conclusions The CALM intervention enhanced psychological resilience, quality of life, and perceived social support among postoperative breast cancer patients. The mediating role of perceived social support emphasizes its significance in promoting well-being. Integrating interventions such as CALM into standard care can contribute to overall well-being and satisfaction in post-mastectomy patients.
Analysis of Thyroid function and Related Factors in Narcolepsy patients
Authors: wang hongli , Jia Mingrui
Published: July 2023

Background: The loss of hypocretin is thought to be the main pathophysiological mechanism of narcolepsy. There is strong evidence that hypocretin is related to the regulation of endocrine functions and depression. To explore thyroid hormone levels in narcolepsy patients was our aim. In addition, further is to analyze the relationship between thyroid hormone levels and sleep quality, anxiety, and depression in narcolepsy patients.
Methods: There are 40 patients with narcolepsy and 40 healthy controls (HCs) were conducted. Blood samples were explored for thyroid function. Correlation analysis between thyroid hormones and clinical characteristics of narcolepsy was performed using Pearson or Spearman.
Results: Narcolepsy patients had significantly lower free thyroxine (FT4) levels in comparison to controls (p ＜ 0.001). No subject was diagnosed with primary hypothyroidism. There were 4 (10 %) subjects with subclinical hypothyroidism. The serum FT4 levels were positively correlated with HAMA14 score (r = -0.343, p = 0.030) by Pearson correlation analysis. The serum TSH levels and HAMD24 score (r = -0.807 p ˂0.001), and ESS score (r = -0.317, p = 0.046) both showed a negative correction.
Conclusion: Hypocretin deficiency may be associated with the regulation of thyroid hormones in narcolepsy patients. The serum thyroid hormones may affect the severity and neuropsychological functions of narcolepsy patients.
Polysaccharide-based hydrogels with self-healing, antibacterial, and antioxidant activity for S. aureus-infected wound healing
Authors: Bai Que , Gou Siyuan , Hu Fangfang , Gao Qian , Zhang Wenhui , Zhang Yanni , Lu Tingli
Published: July 2023

Background
Skin plays an important role in preventing the invasion of disease-causing microorganisms. However, when the skin is damaged, the damaged area is vulnerable to invasion by bacteria and other harmful microorganisms, leading to infection of the wound.
Methods
Here, this paper reported a self-healing, antibacterial, antioxidant multifunctional hydrogel that accelerated healing of infected wounds by releasing curcumin. The internal structure, self-healing, cell compatibility, anti-oxidation, and antibacterial properties of the hydrogel were examined. To assess the healing efficacy of the hydrogel, rat models of tail amputation hemorrhage, liver injury, and skin wound infection were established.
Results
Based on dynamic phenylborate, a multifunctional hydrogel comprising modified quaternary amine chitosan with phenylboric acid was developed. In addition, it was found that the multifunctional hydrogel showed good antioxidant effects on intracellular reactive oxygen species and inhibited the growth of E. coli and S. aureus. Meanwhile, the hydrogel demonstrated self-healing, good biocompatibility, antioxidant, and hemostatic properties. In vivo, the multifunctional hydrogel effectively accelerated the healing of S. aureus-infected skin defects by inhibiting bacteria, suppressing inflammation (down-regulating TNF-α and up-regulating CD206), and promoting angiogenesis (CD31 and α-SMA) and collagen synthesis (Col І).
Conclusion
These results suggest that the developed multifunctional hydrogel dressing provides a beneficial treatment for infected wound healing.
Insights on the Degradation Behavior of Diatom SiO2 Anodes for Lithium-ion Batteries
Authors: Hua Weicheng , Nylund Inger-Emma , Cova Federico , Svensson Ann Mari , Blanco Maria Valeria
Published: July 2023

SiO2 is a promising material for developing high-capacity anodes for lithium-ion batteries (LIBs). However, degradation behavior of SiO2 anodes upon prolonged electrochemical cycling remains unexplored. In this work, the causes leading to capacity fade on SiO2 anodes are investigated and simple strategies to attenuate anode degradation are explored. Nanostructured SiO2 from diatomaceous earth was integrated into anodes containing different quantities of conductive carbon in the form of either a conductive additive or a nanometric coating layer. Galvanostatic cycling was conducted for 200 cycles and distinctive trends on capacity fade were identified. A thorough analysis of the anodes at selected cycle numbers was performed using a toolset of characterization techniques, including electrochemical impedance spectroscopy, FIB-SEM cross-sectional analysis and TEM inspections. Significant fragmentation of SiO2 particles surface and formation of filigree structures upon cycling are reported for the first time. Morphological changes are accompanied by an increase in impedance and a loss of electroactive surface area. Carbon-coating was found to restrict particle fracture and increase capacity retention to 66% compared to 47% for uncoated samples after 200 cycles. Results provide valuable insights to improve cycling stability of SiO2 anodes for next-generation LIBs.
Composition of tempeh metabolome from three seeds (Phaseolus vulgaris L., Glycine max L. and Cicer arietinum L.) treated with two fungi (Rhizopus oryzae and Rhizopus stolonifer)
Authors: Rodriguez Gerardo de Jesus Trujillo , Robledo-Leal Efrén Ricardo , Zapata-Morin Patricio Adrián , Tejero María Elizabeth , Gómez-Govea Mayra Alejandra , Elizondo-Zertuche Mariana , Delgado-Enciso Iván , Martínez-de-Villarreal Laura Elia , Rodríguez-Sanchéz Iram Pablo , González-Luna Aldo Rodrigo
Published: July 2023

The black beans, soybeans, and chickpeas are three of the seeds that make up the top 10 most important grains in the world food industry. Fermentation is an important process that changes the organoleptic and nutritional properties of foods. Fermented foods using strains of Rhizopus spp., and seeds-like based (also known as tempeh) have aroused special interest. The aim of this study was to conduct a comparative analysis of the metabolome of three distinct seeds before and after fermentation with two nonpathogenic funguses (Rhizopus oryzae and Rhizopus stolonifer) using a targeted metabolomic approach. A total of 43 biochemical molecules (12 amino acids and 31 acylcarnitines) were measured in three different seeds fermented by two fungi using mass spectrometer. In the three pulses, the most abundant amino acid was Arg and the most abundant acylcarnitine was C8:1, both of which decreased substantially after 24h exposure to fungi, except for Glma that increases.
Long-term changes on lymphoscintigraphy and their association with clinical parameters in secondary lymphedema after breast cancer surgery
Authors: Hong Garam , Lee Koeun , Han Sangwon , Jeon Jae Yong
Published: July 2023

Purpose: To investigate long-term changes on lymphoscintigraphy and their association with clinical parameters in patients with breast cancer-related lymphedema (BCRL).
Methods: This single-center cohort study included patients with BCRL who underwent baseline and follow-up lymphoscintigraphy. The percentage of excessive circumference (PEC) of the affected upper limb compared with the unaffected side was used as an indicator of the clinical severity of BCRL. Each 99mTc-phytate lymphoscintigraphy image was categorized into 0‒6 stages according to the Taiwan lymphoscintigraphy staging system. Clinical parameters including PEC and the lymphoscintigraphy stage at baseline and follow-up were compared and analyzed.
Results: Eighty-seven patients were included. Baseline and follow-up lymphoscintigraphies were performed at a median 7 (interquartile range [IQR]: 2‒14) and 78 (IQR: 49‒116) months after surgery, respectively. Both lymphoscintigraphy stage and PEC showed variable change during the study period, with overall increases in their severity (median PEC: 3.8–13.4%; median lymphoscintigraphy stage: 1 to 4). PEC and lymphoscintigraphy stage showed positive correlations at baseline (rho = 0.27, P=0.001) and follow-up (rho = 0.50, P<0.001). Stepwise multivariable analysis revealed cellulitis (adjusted β: 4.34; 95% confidence interval [CI]: 0.77‒7.91) and lymphoscintigraphy stage at follow-up (adjusted β: 1.47; 95% CI: 0.67‒2.28) to be independent variables for PEC at follow-up.
Conclusion: The clinical courses of BCRL and patients’ lymphoscintigraphy patterns showed diverse changes over long-term follow-up. In addition to initial lymphoscintigraphy for diagnosis, follow-up lymphoscintigraphy can be useful to visualize functional changes in the lymphatic system that may help to guide the optimal management plan in BCRL.
Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: Novel evidence from tannin conversion, metabolomics, and gut microbiota community analysis
Authors: Zhang Dingkun , Deng Xuan , Li Mengqi , Qiu Min , Zhang Yifan , Li Gefei , Jiang Yurou , Tan Peng , Fan Sanhu , Zheng Youde , Lin Junzhi , Han Li , Huang Haozhou
Published: July 2023

Polyphenols are the main anti-fatigue component of Phyllanthus emblica (PE). However, polyphenols are so easy to transform that it is unknown that how drying and extraction methods driven by heating affect the anti-fatigue effect of PE. This manuscript investigated the effects of five drying methods on the chemical composition transformation and anti-fatigue of PE, and discussed the action mechanism. The results suggested that the anti-fatigue effect of PE with hot-air-dried at 100 ℃ was the best, which was as 1.63 times as that with freeze-drying. Ellagic acid (EA) may be a key component of PE in anti-fatigue, and its mechanism of action may be related to regulating intestinal microbiota, promoting the conversion of EA to urolithin A in vivo, protecting mitochondria, and regulating energy metabolism. This study first revealed the thermal transformation of polyphenols in PE, found the most effective strategy for enhancing the anti-fatigue function, and explores its action mechanism.
Comparison of students' readiness from six health education programs for interprofessional learning in Vietnam: A cross-sectional study
Authors: Huyen Nguyen Thi Thanh , Tam Nguyen Minh , Wens Johan , Tsakitzidis Giannoula , Chi Le Van , Anh Le Ho Thi Quynh , Len Che Thi Len , Chuong Huynh Van , Huy Nguyen Vu Quoc , Valcke Martin
Published: July 2023

Background
Interprofessional education (IPE) is expected to help prepare undergraduate health profession students to collaborate with other healthcare professionals in realising quality of care. Studies stress the necessity of students’ readiness for interprofessional learning (IPL) in view of designing IPE programs. The present study aims to determine students' IPL-readiness and looks at related differences in students enrolled in different programs and at different phases in their educational program.
Methods
A cross-sectional survey study was set up among 1139 students from six health programs at HueUMP, using the Readiness for Interprofessional Learning Scale (RIPLS). Statistical analysis was performed using Kruskal-Wallis H and Mann-Whitney U tests.
Results
The overall mean RIPLS score was 68,89. RIPLS scores significantly differed between programs and between phases in the educational programs. Medical students presented a lower readiness level for IPL than students from other programs. In contrast to a significant increase in RIPLS scores of students in the clinical phase in Vietnamese traditional medicine, medicine, and pharmacy, a decrease in RIPLS scores was observed in students in the clinical phase in odonto-stomatology.
Conclusions
The differences could be related to differences in educational programs and the study phases in a particular program. These results offer insights to direct the design and implementation of IPE in health education curricula and especially underscore the need to provide IPE throughout the curriculum.