bluuebunny/crossref_metadata_2025 huggingface dataset:
Efektivitas Penggunaan Media Kartu Bergambar Untuk Pembelajaran Mufradat Di MI
Authors: Gunawan Riski , Novianti Okta , Zainal Hamdy Mohammad
Published: March 2024

This study aims to determine the effectiveness of using picture card media for mufradat learning at MI Al-Istiqomah Banjit Way Kanan after the development and validation process of the product. Researchers are interested in developing this media because mufradat learning at MI is still using conventional media, so there is a need for media that can assist in mufradat learning at MI Al-Istiqomah Banjit Way Kanan. This study uses the type of research and development (Research and Development) or R&D, namely the research method used to produce a particular product and test the feasibility of the product. Using the ADDIE model developed by Dick and Carry, it is arranged programmatically with systematic sequences of activities in an effort to solve learning problems related to learning resources, needs and learning characteristics. This model consists of five steps, namely: Analysis (analyze), Design (design), Development (development), Implementation (implementation) and Evaluation (evaluation). However, in this study, the researchers only discussed the effectiveness of using picture card media after the expert validation process and product testing. The research instrument used was a questionnaire. While the data analysis technique used is descriptive data analysis technique, namely by describing the effectiveness of using picture card media in mufradat learning. Based on the results of data analysis, after going through the process of product validation and testing and responses from student questionnaires, 80% were in the very effective category. So it can be concluded that the media is feasible, effective and can be used as a supporting medium for learning Arabic, especially mufradat.
Telaah Kritis-Dialogis Mazdhab Linguistik Antara Teori Generative Transformative dan Teori Systematic Functional Linguistik
Authors: Hidayat Nurul , Budianto Langgeng
Published: March 2024

This article discusses and describes the thoughts and arguments that influence the process of linguistic development. There are two mazdhab (groups) of linguistics presented in this article; the generative-transformation theory popularized by Noam Chomsky and the Systemic Functional Grammar theory proposed by the MAK Halliday tradition of thought. This research uses a literature study (library research) method with qualitative descriptive study analysis. The data in this paper is a collection of literacy data derived from books, articles, and journals, as a secondary source to obtain information and explanations in accordance with the research objectives. This article aims to analyze and discover the dialogical-critical relationship between the two mazhabs (groups) of linguistics.
Al-Badlu fi Al-Juz’i Tslasina mina Al-Qur’an wa Tariqaati Tdrisihi
Authors: Tauhid Tauhid , Hakim Rani Ismil
Published: March 2024

Badal Secara bahasa berarti pengganti. Allah SWT berfirman: ”Mungkin Tuhan kita akan memberi kita sesuatu yang lebih baik dari itu”. Secara terminologi, Badal adalah kata pengikut makna dan hukum kalimat atau kata sebelumnya tanpa adanya perantara antara dia dan yang dia ikuti, atau antara penggantinya (badal) dan yang menggantikannya (Mabdul Minhu). Adapun tujuan dari Badal itu adalah untuk menguatkan putusan yang terdahulu, menguatkannya dengan mempertegas maksudnya, memperjelasnya, dan menghilangkan kemungkinan pemahaman lain yang meragukan, karena hukum Badal ini terlebih dahulu diatribusikan kepada yang diikuti, sehingga menyebutkan yang diikuti merupakan persiapan bagi pengikut yang akan dating setelahnya, dan mengarahkan jiwa untuk menerimanya dengan rasa rindu dan penuh semangat. Jika kamu menerimanya dan mengenalnya, maka kamu akan menerima hukum bersamanya dan mengenalnya pula. Seolah-olah putusan tersebut disebutkan dua kali, dan hal ini memperkuat dan meneguhkan putusan tersebut. Badal ada empat jenis yaitu: badal isytimal, badal ba'di min kul, badal kul min kul, badal mutabiq. Kesimpulan dari penelitian ini adalah Juz Tiga Puluh al-Qur’an mengandung berbagai jenis Badal, dan didalamnya terdapat empat puluh tujuh Badal, dan pada ayat-ayat Juz Tiga Puluh terdapat  badal isytimal, badal ba'di min kul, badal kul min kul, badal mutabiq.  dan tidak terdapat badal mubayin pada Juz Tiga Puluh ini karena Badal ini merupakan ucapan bersifat ambigu yang diungkapkan manusia dari dalam dirinya. Adapun kaidah-kaidah Badal pada Juz Tiga Puluh adalah mengganti kata benda dengan kata benda, mengganti kata kerja dengan kata kerja, dan mengganti kata benda semu dengan kata tanya. Dalam penelitian ini peneliti mengungkapkan metode pengajaran kaidah tata bahasa (seperti Badal), antara lain metode standar, metode induktif atau deduktif, metode teks terpadu, metode aktivitas, dan metode masalah (Problem Solving).
The Poet
Authors: Sechi V.
Published: March 2024

The Poet
Steffens und Kierkegaard
Authors: Hultberg H.
Published: March 2024

Steffens und Kierkegaard
Anmeldelser - første del
Authors: Forfattere Forskellige
Published: March 2024

Anmeldelser - første del
Anmeldelser - tredje del
Authors: Forfattere Forskellige
Published: March 2024

Anmeldelser - tredje del
Kolofon
Authors: * * *
Published: March 2024

Kolofon
Kierkegaard og »Forordnet Alter-Bog for Danmark«
Authors: Arildsen Skat
Published: March 2024

Kierkegaard og »Forordnet Alter-Bog for Danmark«
Kierkegaard on Self and Society
Authors: Elrod John W.
Published: March 2024

Kierkegaard on Self and Society
Kierkegaard und Stifter
Authors: Kühnhold Christa
Published: March 2024

Kierkegaard und Stifter. Eine Studie zu übereinstimmenden Zügen ihrer Wirklichkeitsauffassung
Søren Kierkegaard-litteratur 1971-1980: En bibliografi - første del
Authors: Jørgensen Aage
Published: March 2024

Søren Kierkegaard-litteratur 1971-1980: En bibliografi - første del
Anmeldelser
Authors: Forfattere Forskellige
Published: March 2024

Anmeldelser
Angst und Glauben
Authors: Sölle Dorothee
Published: March 2024

Angst und Glauben
Self in/as Other
Authors: Taylor Mark C.
Published: March 2024

Self in/as Other
Har Søren Kierkegaard foregrebet Karen Blixens og Suzanne Brøggers kvindesyn?
Authors: Bertung Birgit
Published: March 2024

Har Søren Kierkegaard foregrebet Karen Blixens og Suzanne Brøggers kvindesyn?
Kierkegaard's Concept of God-Man
Authors: Kearney Richard
Published: March 2024

Kierkegaard's Concept of God-Man
A Critique of Alastair Hannay's Interpretation of the »Philosophical Fragments«
Authors: Roberts Robert C.
Published: March 2024

A Critique of Alastair Hannay's Interpretation of the »Philosophical Fragments«
Lidenskab og livsmod - Søren Kierkegaard og Paul Tillich
Authors: Holm Kjeld
Published: March 2024

Lidenskab og livsmod - Søren Kierkegaard og Paul Tillich
Reply to Roberts's Critique
Authors: Hannay Alastair
Published: March 2024

Reply to Roberts's Critique
Front Matter
Authors: * * *
Published: March 2024

Front Matter
Kierkegaard’s Repetitions: A Rhetorical Reading of Søren Kierkegaard's Concept of Repetition
Authors: Holm Isak Winkel
Published: March 2024

Kierkegaard’s Repetitions: A Rhetorical Reading of Søren Kierkegaard's Concept of Repetition
Kierkegaards Verteidigung der Kontingenz: »Daß etwas Inkommensurables in einem Menschenleben ist«
Authors: Deuser Hermann
Published: March 2024

Kierkegaards Verteidigung der Kontingenz: »Daß etwas Inkommensurables in einem Menschenleben ist«
British Kierkegaard Research: A Historical Survey
Authors: Thomas J. Heywood , Summers Richard
Published: March 2024

British Kierkegaard Research: A Historical Survey
Kierkegaard on Knowledge and Faith
Authors: Emmanuel Steven M.
Published: March 2024

Kierkegaard on Knowledge and Faith
Kierkegaard's Epistemology: A Response to Professor Steven M. Emmanuel's Paper "Kierkegaard on Knowledge and Faith"
Authors: Pojman Louis P.
Published: March 2024

Kierkegaard's Epistemology: A Response to Professor Steven M. Emmanuel's Paper "Kierkegaard on Knowledge and Faith"
Editorial
Authors: Garff Joakim , Grøn Arne , Harbsmeier Eberhard , Watkin Julia
Published: March 2024

Editorial
Selbstverhältnis und Gottesverhältnis bei Augustin und Kierkegaard
Authors: Dietz Walter R.
Published: March 2024

Selbstverhältnis und Gottesverhältnis bei Augustin und Kierkegaard
Løgstrup's Criticism of Kierkegaard - Epistemological and Anthropological Dimensions
Authors: Karlsen Gunnar M.
Published: March 2024

Løgstrup's Criticism of Kierkegaard - Epistemological and Anthropological Dimensions
Grammatik des Glaubens oder Zwischenspiel über den Begriff der Geschichte. Zeit und Geschichte bei Søren Kierkegaard und Walter Benjamin
Authors: Harrits Flemming
Published: March 2024

Grammatik des Glaubens oder Zwischenspiel über den Begriff der Geschichte. Zeit und Geschichte bei Søren Kierkegaard und Walter Benjamin
1993-1994: A Bibliography
Authors: Jørgensen Aage
Published: March 2024

1993-1994: A Bibliography
Paradox und Dialektik. Bemerkungen zu Kierkegaards Christologie
Authors: Ringleben Joachim
Published: March 2024

Paradox und Dialektik. Bemerkungen zu Kierkegaards Christologie
Kierkegaard in Zion
Authors: Golomb Jacob
Published: March 2024

Kierkegaard in Zion
Søren Kierkegaards Teori om Springet og hans Virkelighedsbegreb
Authors: Malantschuk G.
Published: March 2024

Søren Kierkegaards Teori om Springet og hans Virkelighedsbegreb
Eros och agape i Kierkegaards åskådning
Authors: Lindström Valter
Published: March 2024

Eros och agape i Kierkegaards åskådning. Reflexione! kring Per Lønning, »Samtidighedens Situation«. (Oslo, 1954)
A Preface to the "Preface" of Prefaces
Authors: Henriksen Mads Fedder
Published: March 2024

A Preface to the "Preface’" of Prefaces
Der Begriff der Innerlichkeit bei Søren Kierkegaard
Authors: Harbsmeier Eberhard
Published: March 2024

Der Begriff der Innerlichkeit bei Søren Kierkegaard
"We want to see Action!": On Kierkegaard’s Ethical Instruction
Authors: Tajafuerce Begonya Saés
Published: March 2024

"We want to see Action!": On Kierkegaard’s Ethical Instruction
On Occasion of the Public Defence of the Dissertation: Thought in Image: Søren Kierkegaards Poetics
Authors: Holm Isak Winkel
Published: March 2024

On Occasion of the Public Defence of the Dissertation: Thought in Image: Søren Kierkegaards Poetics
Anläßlich der öffentlichen Verteidigung der Dissertation von Das Verhältnis von Vergessen und Schreiben in Kierkegaards Unwissenschaftlicher Nachschrift
Authors: Schmid Hermann
Published: March 2024

Anläßlich der öffentlichen Verteidigung der Dissertation von deDas Verhältnis von Vergessen und Schreiben in Kierkegaards Unwissenschaftlicher Nachschrift
Abraham and Hegel: a Reply to Stewart
Authors: Marino Gordon , Rudd Anthony
Published: March 2024

Abraham and Hegel: a Reply to Stewart
1997-1998: A Bibliography
Authors: Jørgensen Aage
Published: March 2024

1997-1998: A Bibliography
Das komische Pathos. Eine Einführung in Kierkegaards Theorie der Komik
Authors: Olesen Tonny Aagaard
Published: March 2024

Das komische Pathos. Eine Einführung in Kierkegaards Theorie der Komik
La notion de saut chez Søren Kierkegaard: l'exemple de l’amour humain
Authors: Métivier Francis
Published: March 2024

La notion de saut chez Søren Kierkegaard: l'exemple de l’amour humain
Editorial
Authors: Ake Stacey , González Darío , Olesen Tonny Aagaard , Purkarthofer Richard , Soderquist K. Brian , Søltoft Pia , Tajafuerce Begonya Sáez
Published: March 2024

Editorial
Forgiving the Unforgivable: Kierkegaard, Derrida and the Scandal of Forgiveness
Authors: Pyper Hugh
Published: March 2024

Forgiving the Unforgivable: Kierkegaard, Derrida and the Scandal of Forgiveness
Kant and Kierkegaard on the Failure of the Unity of the Self
Authors: Knappe Ulrich
Published: March 2024

Kant and Kierkegaard on the Failure of the Unity of the Self
Die Zweideutigkeit der Reflexion bei G.W.F. Hegel und Søren Kierkegaard
Authors: Poulsen Birgitte Kvist
Published: March 2024

Die Zweideutigkeit der Reflexion bei G.W.F. Hegel und Søren Kierkegaard
El punto de vista sobre mi actividad como escritor: Tan sólo un punto de vista
Authors: Vidal Dolors Perarnau
Published: March 2024

El punto de vista sobre mi actividad como escritor: Tan sólo un punto de vista
Kierkegaard and the Passions of Hellenistic Philosophy
Authors: Furtak Rick
Published: March 2024

Kierkegaard and the Passions of Hellenistic Philosophy
Kierkegaard and Logic
Authors: Holmer Paul L.
Published: March 2024

Kierkegaard and Logic
Kierkegaard in seinem Verhältnis zur deutschen Romantik. Einfluss und Übervindung
Authors: Paulsen Anna
Published: March 2024

Kierkegaard in seinem Verhältnis zur deutschen Romantik. Einfluss und Übervindung
Søren Kierkegaard og Johann Arndt
Authors: Thulstrup Marie Mikulová
Published: March 2024

Søren Kierkegaard og Johann Arndt
Kierkegaard in Brazil
Authors: Reichman Ernani
Published: March 2024

Kierkegaard in Brazil
Ein Existenzphilosoph studiert Kierkegaard
Authors: Bejerholm Lars
Published: March 2024

Ein Existenzphilosoph studiert Kierkegaard
Recentes traductions italiennes de Søren Kierkegaard
Authors: Cortese Alessandro
Published: March 2024

Recentes traductions italiennes de Søren Kierkegaard
Subjektiviteten er sandheden
Authors: Søe N. H.
Published: March 2024

Subjektiviteten er sandheden. Forelæsning ved Københavns Universitets årsfest21.11.1963
Das Verhältnis des Erbaulichen zum Christlichen
Authors: Poulsen Anna
Published: March 2024

Das Verhältnis des Erbaulichen zum Christlichen. Zu Problem der »Erbaulichen Reden« Sören Kierkegaards
Kierkegaard, P. E. Lind og »Johan Gordon«
Authors: Fenger Henning
Published: March 2024

Kierkegaard, P. E. Lind og »Johan Gordon«
Søren Kierkegaard og den kollaterale Tænkning
Authors: Malantschuk G.
Published: March 2024

Søren Kierkegaard og den kollaterale Tænkning
Pascals Gudsbegreb
Authors: Fuglsang-Damgaard H.
Published: March 2024

Pascals Gudsbegreb
Et Blad af Hans Bröchner-Forskningens Historie
Authors: Arildsen Skat
Published: March 2024

Et Blad af Hans Bröchner-Forskningens Historie. Dr. phil. S. V. Rasmussen: Den unge Brochne
Søren Kierkegaard et la littérature française
Authors: Billeskov Jansen F. J.
Published: March 2024

Søren Kierkegaard et la littérature française. Søren Kierkegaard and French Literature, Eight Comparative Studies by Ronald Grimsley. Cardiff. University of Wales Press. 1966. 171 p.
Noter
Authors: * * *
Published: March 2024

Noter
Kierkegaard and Optical Linguistics
Authors: Charlesworth James H.
Published: March 2024

Kierkegaard and Optical Linguistics
Anmeldelser - anden del
Authors: Forfattere Forskellige
Published: March 2024

Anmeldelser - anden del
Søren Kierkegaard og Heine
Authors: Bukdahl Jørgen
Published: March 2024

Søren Kierkegaard og Heine
Kierkegaard og Foreningen af Kristne
Authors: Larsen Emil
Published: March 2024

Kierkegaard og Foreningen af Kristne
Villads Christensen 16.3. 1883 - 10.10. 1969 - in memoriam
Authors: Malantschuk G.
Published: March 2024

Villads Christensen 16.3. 1883 - 10.10. 1969 - in memoriam
Kierkegaard on the Structure of Selfhood
Authors: Taylor Mark C.
Published: March 2024

Kierkegaard on the Structure of Selfhood
The Increase of Christian Terms in Kierkegaard's Samlede Værker
Authors: McKinnon Alastair
Published: March 2024

The Increase of Christian Terms in Kierkegaard's Samlede Værker
Mujer, Guerra Civil y represión franquista en 'Un largo silencio', de Ángeles Caso
Authors: Xia Xiyao
Published: March 2024

Un largo silencio es una novela publicada en los albores del siglo XXI, en medio de los llamamientos en pro de la recuperación de la memoria histórica de la Guerra Civil española. En esta obra, Ángeles Caso revela la represión franquista, en colusión de la cultura misógina, que martirizó a las mujeres republicanas como grupo marginal, denostado por ser mujeres y por haber defendido la igualdad y la República española. Este trabajo pretende ahondar en la perspectiva femenina de la autora que ha convertido a las mujeres en protagonistas en la lucha contra la dictadura, y destacar su intención de despertar el interés del público en relación con la memoria histórica.
“La insolidaridad localista y rencorosa”. Novelas de regresos imposibles a la España fracturada en el catálogo invisible del editor Carlos Barral
Authors: Suárez Toledano Cristina
Published: March 2024

La censura editorial franquista impidió la representación literaria de realidades y procesos conflictivos que comprometían la imagen pública del régimen, como el relato del protagonista que regresa a su pueblo tras un destierro en otros lugares, o tras haber estado en prisión, y se encuentra con “la insolidaridad localista y rencorosa” de sus vecinos, como recogieron los censores. Conviene recuperar la memoria literaria censurada de personajes que representan realidades como las que se localizan en cuatro novelas del catálogo invisible del editor Carlos Barral: Estos son tus hermanos, Al regreso del Boiras, Crónica de un regreso y La tierra prometida.
Isabel Navas Ocaña y Dolores Romero López (eds.): 'Ciberfeminismos, tecnotextualidades y transgéneros. Literatura digital en español escrita por mujeres'
Authors: Patrón Sánchez Marina
Published: March 2024

Reseña del volumen colectivo Ciberfeminismos, tecnotextualidades y transgéneros. Literatura digital en español escrita por mujeres editado por Isabel Navas Ocaña y Dolores Romero López y publicado en la Editorial Universidad de Almería y Ediciones Complutense, 2023, 396 pp.
The continuity of the didactic principle in teaching violin playing in China
Authors: Fang Jinwen
Published: March 2024

The study of continuity between generations is the subject of interest for specialists working in various scientific fields, such as philosophy, cultural studies, pedagogy, psychology, art criticism and others. This problem attracts the attention of scientists and researchers who seek to understand how knowledge and values are transmitted and preserved in various spheres of human activity. Thanks to this interdisciplinary approach, we can gain a deeper understanding of the importance of the succession process in society and culture. In this article, the author addresses the topical issue of violin education in China, its main characteristics and problems of continuity. The issue of continuity in philosophy, cultural studies, pedagogy, psychology, and art criticism is considered from various points of view. The role of the didactic principle of continuity for the Russian violin school is emphasized. The author analyzes the state of modern violin education in China with an emphasis on the main problems and tasks of violin pedagogy. The article uses methods of comparative analysis, examines the history of violin art in Russia and China, describes the educational process in China, identifies the main problems and suggests ways to solve them. There is still very fierce competition in China for admission to professional music universities: according to statistics, out of the total population of the country, only about 15 students enter the conservatory in the violin specialty every year. Despite the fact that violin education in China is organized according to international standards, there are separate problems in the field of pedagogy and performance that need to be solved. Improving the methodology of teaching violin playing (from the very initial level), increasing the professionalism of teachers, expanding the staff of qualified personnel and creating pedagogical conditions – all this will help make the professional training of future violinists effective and strengthen the position of the Chinese violin school at the world level. To date, there is an obvious tendency to transform the foundations established in the educational methodology with a refocus on the individual qualities of the student and the development of his independence. Teachers select new repertoires, which include both classical works and outstanding works by contemporary authors.
The specifics of teaching the techniques of conducting gesture in the "Choral conducting" classroom
Authors: Movchan Larisa Anatol'evna
Published: March 2024

The profession of conductor is one of the most important musical specialties in the world. The conductor plays the role of the head of the orchestra or choir, is responsible for the accuracy and expressiveness of the sound of the work, and serves as an intermediary between the author and the performer. The nature of the music and the performance interpretation depend on the correct work of the conductor. There is an educational side to the conductor's work. The choirmaster, engaged in teaching, solves a number of educational tasks. The article examines the specifics of teaching conducting gesture techniques in the classroom in the specialty "Choral conducting", highlights the main aspects and problems of conducting a choral group, and compares the work of a choral and symphonic conductor. The technique of managing a vocal group – an academic, folk or church choir - implies the ability to read scores in different keys, arrange them, and correctly distribute the parts depending on the characteristics of the voices. The choir director also works with the literary text of vocal compositions. It is impossible to do without general musical and theoretical knowledge in the field of solfeggio, harmony, and polyphony. The technique of staging the conducting apparatus and the schedule of the timing schemes practically do not differ among the heads of instrumental and vocal groups. This can be explained by the general nature, the psychology of collective music making. However, we must not forget about the specific features of choral conducting. This is the relative smoothness of gestures due to the different allocation of voices than in the orchestra, as well as the non-use of the conductor's baton. The second important difference between a choirmaster and a symphonic conductor is the need to analyze not only the musical, but also the verbal text of the score. The characteristic of the composer's work is added to the characteristic of the poet's work or the features of oral folk art, if the exact author of the text is unknown. In the work of a chorus conductor, vocal performance is of great importance, which is related to the possibilities of the voice. Choral conducting is more intimate than orchestral conducting. The most obvious synthesis of these arts, which almost completely eliminates all differences, can be noted in the management of both vocal and instrumental groups at once: in operas, cantatas, oratorios.
Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate
Authors: Seedhom Mina O , Dersh Devin , Holly Jaroslav , Pavon-Eternod Mariana , Wei Jiajie , Angel Matthew , Shores Lucas , David Alexandre , Santos Jefferson , Hickman Heather , Yewdell Jonathan W
Published: March 2024

Rapid lymphocyte cell division places enormous demands on the protein synthesis machinery. Flow cytometric measurement of puromycylated ribosome-associated nascent chains after treating cells or mice with translation initiation inhibitors reveals that ribosomes in resting lymphocytes in vitro and in vivo elongate at typical rates for mammalian cells. Intriguingly, elongation rates can be increased up to 30% by activation in vivo or fever temperature in vitro. Resting and activated lymphocytes possess abundant monosome populations, most of which actively translate in vivo, while in vitro, nearly all can be stalled prior to activation. Quantitating lymphocyte protein mass and ribosome count reveals a paradoxically high ratio of cellular protein to ribosomes insufficient to support their rapid in vivo division, suggesting that the activated lymphocyte proteome in vivo may be generated in an unusual manner. Our findings demonstrate the importance of a global understanding of protein synthesis in lymphocytes and other rapidly dividing immune cells.
Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states
Authors: Yao Junjun , Dai Shaoxing , Zhu Ran , Tan Ju , Zhao Qiancheng , Yin Yu , Sun Jiansen , Du Xuewei , Ge Longjiao , Xu Jianhua , Hou Chunli , Li Nan , Li Jun , Ji Weizhi , Zhu Chuhong , Zhang Runrui , Li Tianqing
Published: March 2024

While accumulated publications support the existence of neurogenesis in the adult human hippocampus, the homeostasis and developmental potentials of neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucleus atlas of the human hippocampus across neonatal, adult, aging and injury, we dissected the molecular heterogeneity and transcriptional dynamics of human hippocampal NSCs under different contexts. We further identified new specific neurogenic lineage markers that overcome the lack of specificity found in some well-known markers. Based on developmental trajectory and molecular signatures, we found that a subset of NSCs exhibit quiescent properties after birth, and most NSCs become deep quiescence during aging. Furthermore, certain deep quiescent NSCs are re-activated following stroke injury. Together, our findings provide valuable insights into the development, aging, and re-activation of the human hippocampal NSCs, and help to explain why adult hippocampal neurogenesis is infrequently observed in humans.
Species -Shared and -Unique Gyral Peaks on Human and Macaque Brains
Authors: Zhang Songyao , Zhang Tuo , Cao Guannan , Zhou Jingchao , He Zhibin , Li Xiao , Ren Yudan , Liu Tao , Jiang Xi , Guo Lei , Han Junwei , Liu Tianming
Published: March 2024

Cortical folding is an important feature of primate brains that plays a crucial role in various cognitive and behavioral processes. Extensive research has revealed both similarities and differences in folding morphology and brain function among primates including macaque and human. The folding morphology is the basis of brain function, making cross-species studies on folding morphology important for understanding brain function and species evolution. However, prior studies on cross-species folding morphology mainly focused on partial regions of the cortex instead of the entire brain. Previously, we defined a whole-brain landmark based on folding morphology: the gyral peak. It was found to exist stably across individuals and ages in both human and macaque brains. In this study, we identified shared and unique gyral peaks in human and macaque, and investigated the similarities and differences in the spatial distribution, anatomical morphology, and functional connectivity of them.
Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles
Authors: Lee Selene Seoyun , Civitelli Livia , Parkkinen Laura
Published: March 2024

The alpha-synuclein (
α
Syn) seeding amplification assay (SAA) that allows the generation of disease-specific in vitro seeded fibrils (SAA fibrils) is used as a research tool to study the connection between the structure of
α
Syn fibrils, cellular seeding/spreading, and the clinico-pathological manifestations of different synucleinopathies. However, structural differences between human brain-derived and SAA
α
Syn fibrils have been recently highlighted. Here, we characterize biophysical properties of the human brain-derived
α
Syn fibrils from the brains of patients with Parkinson’s disease with and without dementia (PD, PDD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA) and compare them to the ‘model’ SAA fibrils. We report that the brain-derived
α
Syn fibrils show distinct biochemical profiles, which were not replicated in the corresponding SAA fibrils. Furthermore, the brain-derived
α
Syn fibrils from all synucleinopathies displayed a mixture of ‘straight’ and ‘twisted’ microscopic structures. However, the PD, PDD, and DLB SAA fibrils had a ‘straight’ structure, whereas MSA SAA fibrils showed a ‘twisted’ structure. Finally, the brain-derived
α
Syn fibrils from all four synucleinopathies were phosphorylated (S129). However, the phosphorylation pattern was not maintained in the SAA fibrils, where only PDD and DLB SAA fibrils showed weak signs of phosphorylation. Our findings demonstrate the limitation of the SAA fibrils modelling the brain-derived
α
Syn fibrils and pay attention to the necessity of deepening the understanding of the SAA fibrillation methodology.
Mechanism of dimer selectivity and binding cooperativity of BRAF inhibitors
Authors: Clayton Joseph , Romany Aarion , Matenoglou Evangelia , Gavathiotis Evripidis , Poulikakos Poulikos I , Shen Jana
Published: March 2024

Aberrant signaling of BRAFV600E is a major cancer driver. Current FDA-approved RAF inhibitors selectively inhibit the monomeric BRAFV600E and suffer from tumor resistance. Recently, dimer-selective and equipotent RAF inhibitors have been developed; however, the mechanism of dimer selectivity is poorly understood. Here, we report extensive molecular dynamics (MD) simulations of the monomeric and dimeric BRAFV600E in the apo form or in complex with one or two dimer-selective (PHI1) or equipotent (LY3009120) inhibitor(s). The simulations uncovered the unprecedented details of the remarkable allostery in BRAFV600E dimerization and inhibitor binding. Specifically, dimerization retrains and shifts the αC helix inward and increases the flexibility of the DFG motif; dimer compatibility is due to the promotion of the αC-in conformation, which is stabilized by a hydrogen bond formation between the inhibitor and the αC Glu501. A more stable hydrogen bond further restrains and shifts the αC helix inward, which incurs a larger entropic penalty that disfavors monomer binding. This mechanism led us to propose an empirical way based on the co-crystal structure to assess the dimer selectivity of a BRAFV600E inhibitor. Simulations also revealed that the positive cooperativity of PHI1 is due to its ability to preorganize the αC and DFG conformation in the opposite protomer, priming it for binding the second inhibitor. The atomically detailed view of the interplay between BRAF dimerization and inhibitor allostery as well as cooperativity has implications for understanding kinase signaling and contributes to the design of protomer selective RAF inhibitors.
Foveavelia, a new South American genus of Veliinae (Hemiptera: Heteroptera: Veliidae)
Authors: Rodrigues Higor D. D. , Moreira Felipe F. F.
Published: March 2024

Background

Semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha) are distributed worldwide and play fundamental roles in limnic ecosystems. They are the most successful group of organisms to occupy the air-water interface, are important models to study ecology and evolution, and can be relevant tools in biomonitoring. Veliidae is the second most speciose family of semiaquatic bugs, but its internal classification, including subfamilies and genera, is artificial and based on symplesiomorphies. One of these non-monophyletic entities is Paravelia Breddin, 1898, the largest genus in the subfamily Veliinae.

Results

In an effort to better classify the Veliinae, we describe Foveavelia to hold five South American species previously placed in Paravelia. The new genus is characterized by the following combination of features: unusual coarse cuticular punctures throughout the thorax and abdomen; a pair of small, frosty, pubescent areas formed by a very dense layer of short setae on the anterior lobe of the pronotum; fore tibial grasping comb present only in males; middle tibia with a row of elongate dark-brown trichobothria-like setae on the distal third, decreasing in size distally; macropterous specimens with the apical macula of the forewings elongate and constricted at mid-length, reaching the wing apex; and the male proctiger with a pair of anterodorsal projections. Besides the description, a key to the species of Foveavelia is provided, accompanied by illustrations and a species distribution map.
Inulin protects against the harmful effects of dietary emulsifiers on mice gut microbiome
Authors: Bekar Cansu , Ozmen Ozlem , Ozkul Ceren , Ayaz Aylin
Published: March 2024

Background

The prevalence of inflammatory bowel diseases is increasing, especially in developing countries, with adoption of Western-style diet. This study aimed to investigate the effects of two emulsifiers including lecithin and carboxymethyl cellulose (CMC) on the gut microbiota, intestinal inflammation and the potential of inulin as a means to protect against the harmful effects of emulsifiers.

Methods

In this study, male C57Bl/6 mice were divided into five groups (n:6/group) (control, CMC, lecithin, CMC+inulin, and lecithin+inulin). Lecithin and CMC were diluted in drinking water (1% w/v) and inulin was administered daily at 5 g/kg for 12 weeks. Histological examination of the ileum and colon, serum IL-10, IL-6, and fecal lipocalin-2 levels were analyzed. 16S rRNA gene V3-V4 region amplicon sequencing was performed on stool samples.

Results

In the CMC and lecithin groups, shortening of the villus and a decrease in goblet cells were observed in the ileum and colon, whereas inulin reversed this effect. The lipocalin level, which was 9.7 ± 3.29 ng in the CMC group, decreased to 4.1 ± 2.98 ng with the administration of inulin. Bifidobacteria and Akkermansia were lower in the CMC group than the control, while they were higher in the CMC+inulin group. In conclusion, emulsifiers affect intestinal health negatively by disrupting the epithelial integrity and altering the composition of the microbiota. Inulin is protective on their harmful effects. In addition, it was found that CMC was more detrimental to microbiota composition than lecithin.
Relationship between Sleep Deprivation and Daytime Sleepiness in different Groups of the Population: A Cross-sectional Study
Authors: Akhlad Madeeha , Siddiqui Hammad Ahmed , Azharuddin Muhammad
Published: March 2024

Introduction: Research consistently indicates that insufficient sleep, whether it is a persistent or short-term issue, can result in daytime sleepiness among the general population. Contributing factors include demanding work schedules, social commitments, and the habit of using electronic devices before bedtime. Aim: To find the relationship between sleep deprivation, daytime sleepiness, and socio-economic status, and their association among teachers, bachelor’s and master’s students, and medical practitioners. Materials and Methods: This cross-sectional study included the assessment of daytime sleepiness and quality of sleep among different populations using the Eppworth Sleepiness Scale (ESS) and the Pittsburgh Sleep Quality Index (PSQI), respectively. The socio-economic status was assessed using the modified Kuppuswamy Scale (mKS). The participants were categorised into three groups: teachers, students, and medical professionals according to their profession. In the analysis, to find the linear relationship between age, Body Mass Index (BMI), and the other three outcomes, Pearson’s correlation was used. Results: There were 65 (38.5%) males and 104 (61.5%) females among the respondents. On analysis, considering the overall results, it was found that there was a moderate positive correlation between age and BMI (r-value=0.232, p-value<0.05) and no significant correlation between age and ESS, PSQI, mKS. There was a moderately negative correlation between mKS and ESS (r-value=-0.205, p-value=0.016), suggesting that the lower the SES, the more the chances of daytime sleepiness in students’ group. In the teacher’s group, there was no significant correlation between age and BMI, ESS, PSQI, and mKS in any of the groups. Conclusion: It can be concluded that daytime sleepiness was related to socio-economic status in students, such that they are inversely proportional to each other. Medical practitioners experienced the most daytime sleepiness compared to other population groups.
Molecular Docking Study on Phytochemicals of Alpinia galanga and Their Derivatives as Inhibitors of β-Ketoacyl Reductase (MabA) of Mycobacterium Tuberculosis: An In-silico Study
Authors: Savetha Palaneswamy , Premalatha Ethirajulu , Sharavanan Tanjavur Kaderesan Veerappan , Sangeetha Belukurichi Sadasivam , Kannan Iyanar
Published: March 2024

Introduction: Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium Tuberculosis (MTB), continues to be a global health problem. Alpinia galanga (Linn.) of the Zingiberaceae family has antitubercular properties, and their mode of action in in-vitro as well as in-vivo conditions is well established. This knowledge of the active phytochemicals of Alpinia galanga has been utilised to identify new potent drugs for MTB. Aim: To perform molecular docking studies of various phytochemicals of Alpinia galanga and their derivatives with β-ketoacyl reductase (MabA) of MTB. Materials and Methods: The present study is an in-silico study conducted in the Bioinformatics facility of the Central Research Laboratory of Tagore Medical College and Hospital, Chennai, Tamil Nadu, India from November 2022 to April 2023. The receptor protein was downloaded from the Research Collaboratory for Structural Bioinformatics (RCSB) database. The phytochemicals in. sdf format were downloaded from the PubChem database. The derivatives were prepared by Chemsketch software. Docking was performed using AutoDock Vina with PyRx as the GUI (Graphical User Interface). Postdocking analysis was performed in LigPlot+. Results: Phytochemicals from Alpinia galanga were obtained from the PubChem database and docked with MabA of MTB. The derivatives were further subjected to docking analyses. From the docking study, two molecules, namely, (1E,6Z)-2,4-diamino6-fluoro-1,7-bis(4-hydroxyphenyl)-1-sulfanylhepta-1,6-diene3,5-dione and (2E,6Z,10E)-2,6,9,9-tetrakis(hydroxymethyl) cycloundeca-2,6,10-trien-1-one-ethane (1/1), were found to have good binding energy values. Conclusion: The present study helped us find drug-like molecules that can inhibit the MabA of MTB. Two compounds derived from the phytochemicals of A. galanga were found to have an effective binding capacity to the drug target in-silico. Hence, the outcome of present study has provided a therapeutic strategy for TB, especially for strains of MTB that are drug-resistant.
Study on Learning Assurance of High-Impact Teaching in Consumer Behavior Course
Authors: Yen Tsaifa TF
Published: March 2024

High-impact teaching philosophy helps students to expand their learning, exercise their critical thinking skills and apply the professional knowledge they have learned, which not only promotes the learning effect during the school year, but also focuses on the career development of students. However, less research has focused on learning security under high-impact teaching concepts. Therefore, the purpose of this paper is to explore the assurance of high impact teaching in consumer behavior in the learning effect, and put forward suggestions. This study obtained data through course summary and office hour records, and concluded which measures were more effective through text analysis. The research finds that students' text analysis shows that practical training programs can best promote theoretical knowledge learning and ability training, and office hour can indeed help students establish career goals. Finally, it is suggested that schools should put forward an incentive scheme for high-impact teaching.
Myocardial Infarction Seen Tardively Complicated by Ventricular Septal Rupture Extending to the Right Ventricule: A Dilemmatic Scenario
Authors: Njie M. , Mulendele P. M , Mahi A. EL , Timimi A. AL , Hayar S. , Assklou A. , Arous S. , Drighil A. , Habbal R.
Published: March 2024

Ventricular septal rupture (VSR) is an uncommon but well-recognized mechanical complication of acute myocardial infarction (MI). Mortality without intervention is 70% in intrahospital at 30 days, and 90% at one year due to cardiogenic shock. Transthoracic echocardiography (TTE) is the choice tool in the diagnosis and evaluation of VSR. We report an original case of a 72-year-old patient diagnosed with myocardial infarction of the inferior wall of the left ventricle, complicated by the rupture of its basal segment aneurysm extending to the right ventricle. After which standard drug treatment was prescribed. Inferior wall myocardial infarction complicated with VSR at its basal segment is a rare mechanical complication of MI and this clinical case shows a rare location of VSR compared to forms described in the literatures. On the third day, the patient died from refractory cardiogenic shock, and neurological complications which could have been prevented by surgery. Treatment of VSR secondary to MI is an emergency based on either an open heart surgery or percutaneous intervention inorder to reduce morbi-mortality rate.
Evaluation of Local Common Bean (Phaseolus vulgaris L.) Genotypes for Resistance to Fungal Diseases in the Bimodal-rainfall Forest Zone of Cameroon
Authors: Nineck Tchang Hourounou , Bertrant Mboussi Serge , Thierry Molo , Shérifa Molo Nathalie , Landry Ndzana Ndzana Emile Lionel , Constant Likeng-Li-Ngue Benoit
Published: March 2024

The general objective of the present study was to evaluate the susceptibility to fungal diseases of some bean collections in the bimodal rainfall forest zone of Cameroon. To this end, 12 bean collections from Foumbot were grown at the University of Yaoundé I in a completely randomized block design without phytosanitary treatments. Symptoms identified on the leaves of diseased plants were used to characterize the fungal agents in the laboratory using an identification key. Incidence and severity were assessed, as well as the number of pods and seeds in plants under fungal pressure. Following the evolution of symptoms, all collections showed fungal disease attacks at different rates. Macroscopic and microscopic laboratory observations identified Sclerotinia sclerotiorum, Uromices appendiculatus and Fusarium solani as the fungal agents responsible for these symptoms. The incidence of disease caused by F. solani was lower in the NJBPRNV (16.67%) and NJBV (22.22%) collections, as was severity (3.33% and 4.44%). On the other hand, the LGRTE (47.06%) and GGRBE (44.44%) LGRV (43.75%) collections showed high incidences of disease caused by S. sclerotiorum, U. appendiculatus and F. solani respectively. Considering the number of seeds, the KPGPV (403.2 seeds) and KPGPTV (350.4 seeds) collections recorded the highest number of seeds, compared with the GGRBE (15.93 seeds); LGRTE (23.87 seeds); GGRBTE (25.53 seeds); LGRV (42.4 seeds) and GGRTE (52.2 seeds) collections. However, the NJBPRNV collection requires special attention in varietal creation, given its greater resistance to the fungal diseases identified.
Bacterial Diversity of the Silverleaf Whitefly, Bemisia tabaci (Gennadius), Collected on Jasmine and Chrysanthemum
Authors: Pujar Kishor , Shivanna, B.  , Naik, D. Jemla
Published: March 2024

The adults and nymphs of Bemisia tabaci were collected on jasmine and chrysanthemum during 2021-2023 from Southern part of Karnataka, India. Bacterial colonies were isolated from adults and nymphs of B. tabaci using spread-plate technique and identified through 16srRNA sequencing. The B. tabaci collected on jasmine harboured more number of bacteria (8 species) than chrysanthemum (5 species). Most bacterial species isolated from B. tabaci, collected on jasmine and chrysanthemum, belonged to the phylum Bacillota (62.5 and 60 percent). Similarly, Bacilli, Bacillales and Bacillaceae were the dominant class, order and family of the bacteria associated with B. tabaci. Nymphs harboured higher number of bacteria than adults in both jasmine (62.5 and 33.5 percent, respectively) and chrysanthemum (60 and 40 percent, respectively). Bacillus cereus and B. pumilus were commonly found species from the nymphs and adults of B. tabaci on jasmine. When insect hosts shifted, change in the nutrition and defence system of the host plant influences the bacterial diversity of the insect.
Overview of the Current Research Status of Concrete-Filled Steel Tube
Authors: Hao Yang
Published: March 2024

Steel tube concrete refers to a composite structure formed by filling concrete in a steel tube, and the steel tube and its core concrete can jointly bear external loads. The seismic performance of composite structures largely depends on the strength and ductility of the columns. In the structure, columns are the main vertical load-bearing components due to their high strength and good ductility. However, under seismic action, steel tube concrete columns may experience end steel tube wall buckling, and the concrete inside the pipes may be crushed and lose its load-bearing capacity, causing the overall structure to collapse. In order to better utilize the performance of steel tube concrete, this study analyzes the research of scholars and explores the axial compression performance, failure modes, and local buckling effects of different types of concrete filled in steel tubes on the structural performance of steel tube concrete. Therefore, it is particularly important to study the axial compression performance of steel-concrete columns and explore reasonable design methods to delay the local buckling of steel pipes, and accurately evaluate the seismic performance of steel-concrete columns under large earthquake responses.
Making connections in learning to read and to spell
Authors: Bradley Lynette
Published: May 2007

A recent intervention study demonstrated a powerful method for helping children with difficulty in sound categorization to learn to read and to spell. The aim of this project is to explain the underlying reasons for its success. The project is divided into three stages, Pretests, Training and Post‐tests, which cover a period of 3 years. The subjects were young beginning readers, who were pre‐tested on the strategies used in the successful teaching method, and then followed in school for 3 years to see how their skill in these strategies affected their progress in reading and spelling. They were divided into four matched groups in the second term of the project for a short training study. Phonological awareness when the child started school proved to be critical for success in early reading, and in spelling 2 years later. Memory for letter strings becomes increasingly important for spelling. Beginning readers who were taught the connection between the two strategies made early gains in reading text.
The framing heuristic influences judgements about younger and older adults' decision to refuse medical treatment
Authors: Rybash John M. , Roodin Paul A.
Published: May 2007

Three‐hundred and one young adults evaluated medical dilemmas in which a patient (1) was portrayed as either 40 or 70 years old, (2) decided to either refuse or consent to a risky treatment for a serious medical disorder, and (3) received either positively or negatively framed information about the potential effectiveness of a proposed medical treatment. Participants' evaluations of the patients' decisions reflected the implementation of a framing heuristic and an age heuristic. The framing heuristic influenced participants' judgements of patients who refused the proposed treatment. Specifically, information which was positively framed resulted in risk‐avoiding judgements, while information which was negatively framed resulted in risk‐taking judgements. The age heuristic predisposed participants to recommend that 40 year old patients, more so than 70‐year‐old patients, opt for high‐risk medical treatments that could potentially add a large number of years to their lives.
Knowledge Organization and the Acquisition of Procedural Expertise
Authors: Zeitz Colleen M. , Spoehr Kathryn T.
Published: May 2007

The influence of the organization of a declarative knowledge base on the development and application of proceduralized knowledge was investigated in a complex troubleshooting domain. Domain explanations were generated in either a depth‐first or breadth‐first manner for different groups of subjects who were also given experience learning to troubleshoot in the domain. Although the two explanatory structures led to similar training performance, the two groups differed significantly in their overall level of performance in subsequent troubleshooting problems. Examination of objective measures of troubleshooting performance and think‐aloud protocols indicated that breadth‐first declarative knowledge representation fosters the use of mental models during problem‐solving in training. It also facilitates proceduralization of that knowledge into fast and accurate methods for localizing faults.