bluuebunny/crossref_metadata_2025 huggingface dataset:
The relationship between endothelial progenitor cells and pulmonary hypertension in children with congenital heart disease
Authors: Sun Hong-Xiao , Li Guo-Ju , Du Zhan-Hui , Bing Zhen , Ji Zhi-Xian , Luo Gang , Pan Silin
Published: November 2019

Background: To assess the relationship between endothelial progenitor cells (EPCs) in peripheral blood and pulmonary hypertension (PH) in children with congenital heart disease (CHD) and explore the possibility of applying EPCs to treatment of PH in children with CHD. Methods: In this study, a total of 173 cases with CHD (from 0 to 6 years old) were collected. According to the right heart catheterization of mean pulmonary arterial pressure (mPAP) results, these cases were divided into PH groups (including high PH group, n=32, and the middle PH group, n=30) and non-PH group (n=111). We took their peripheral blood for flow cytometry, and counted the number of EPCs(CD133+/KDR+ cells). The number of EPCs /μL of peripheral blood was calculated using the following formula: EPCs /μL =WBC /L × lymphocytes % × EPCs % × 10-6. Results: The median EPCs of the non-PH group, middle PH group and high PH group are 1.86/μL, 1.30 /μL and 0.98/μL, respectively. The mPAP decreases steadily as the level of EPCs increases (P<0.05). After adjustment of gender, age and BMI, the EPCs was significantly associated with a decreased risk of high PH (OR=0.37, 95%CI: 0.16-0.87, P<0.05). However, EPCs was not significantly associated with middle PH (P>0.05). Conclusion: The findings revealed that the EPCs and high PH in CHD patients correlate significantly and EPCs may become an effective treatment for PH in CHD patients.EPCs may be a protective factor of high PH for children with CHD.
Integrated Care Search: Development and validation of a PubMed search filter for retrieving the integrated care research evidence
Authors: Damarell Raechel A. , Lewis Suzanne , Trenerry Camilla , Tieman Jennifer J.
Published: November 2019

Background Integrated care is an increasingly important principle for organising healthcare. Integrated care models show promise in reducing resource wastage and service fragmentation whilst improving the accessibility, patient-centredness and quality of care for patients. Those needing reliable access to the growing research evidence base for integrated care can be frustrated by search challenges reflective of the topic's complexity. The aim of this study is to report the empirical development and validation of two search filters for rapid and effective retrieval of integrated care evidence in PubMed. One filter is optimised for recall and the other for precision.Methods An Expert Advisory Group comprising international integrated care experts guided the study. A gold standard test set of citations was formed from screening Handbook Integrated Care chapter references for relevance. This set was divided into a Term Identification Set (20%) for determining candidate terms using frequency analysis; a Filter Development Set (40%) for testing performance of term combinations; and a Filter Validation Set (40%) reserved for confirming final filter performance. In developing the high recall filter, recall was steadily increased while maintaining precision at ≥ 50%. Similarly, the high precision filter sought to maximise precision while keeping recall ≥ 50%. For each term combination tested, an approximation of precision was obtained by reviewing the first 100 citations retrieved in Medline for relevance.Results The gold standard set comprised 534 citations. The search filter optimised for recall ('Broad Integrated Care Search') achieved 86.0%-88.3% recall with corresponding low precision (47%-53%). The search filter optimised for precise searching ('Narrow Integrated Care Search') demonstrated precision of 73%-95% with recall reduced to between 55.9% and 59.8%. These filters are now available as one-click URL hyperlinks in the website of International Foundation for Integrated Care.Conclusions The Broad and Narrow Integrated Care Search filters provide potential users, such as policy makers and researchers, seamless, reliable and ongoing access to integrated care evidence for decision making. These filters were developed according to a rigorous and transparent methodology designed to circumvent the challenges of information retrieval posed by this complex, multifaceted topic.
Power and complexity in obstetric teamwork: an observational study.
Authors: Neuhaus Christopher , Lutnaes Dag Erik , Bergström Johan
Published: November 2019

Background In recent years, increasing attention has been paid to team processes in peripartum care settings with the aim to improve fetomaternal outcomes. However, we have yet to understand how the perception of teamwork in peripartum care is shaped in a complex, multi-disciplinary environment.Methods The aim of this study was to approach the question using a qualitative social-scientific methodology. The theoretical foundation of the study was that obstetric teamwork is the result of a balancing act in which multiple goal conflicts are continuously negotiated and managed right at the boundary of acceptable performance in a complex adaptive system. We explored this theory by gathering lived experiences, from multiple perspectives, of successful management of peripartum emergencies in the setting of a German university hospital. Based on our analysis we generated an understanding of teamwork as a phenomenon emerging from interpersonal relationships, complex relations of power, and the enactment of current quality management practices.Results Caregivers often define teamwork through the quality of their collaboration, defined by respect and appreciation, open communication, role distribution, and shared experiences. However, teamwork also becomes the framework for negotiation of many conflicts that originated elsewhere. Power, in various forms, was the core theme that emerged in the analysis of our participants’ narratives, which is in stark contrast to the otherwise promoted egalitarian rhetoric of team training. While our participants generally reverted to explanations based on their professional identities, traditions or cultures, interesting dynamics become visible when work is viewed through the power lens.Conclusions Our study paints the convoluted picture of a work environment with all its intricacies, constraints, interpersonal relations and hierarchical struggles that are much more representative of a complex system rather than the easily tractable environment that so many stakeholders would like healthcare practitioners to believe in. The issue of power emerged as a decisive factor in the social dynamics at the workplace, revealing hidden agendas in the teamwork discourse.
Determinants of Non-Hodgkin's Lymphoma at Felegehiwot Specialized Hospital, North West Ethiopia: a case-control study
Authors: Chekol Dessalegn , Bedimo Melkamu , Mulugeta Yihun , Bantie Getasew
Published: November 2019

Background The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors. Hence, the purpose of this study was to identify determinants of Non-Hodgkin lymphoma cancer among individuals who were diagnosed at Felegehiwot specialized hospital, North West Ethiopia, 2019.Methods An institution-based unmatched case-control study was conducted at Felegehiwot Specialized hospital from December 2018 up to June 2019. The sample size calculated using the two population proportion formula with 1:2 cases to control ratio. Then the final sample size was 486, (162cases and 324 controls). The simple random sampling method was employed to catch up with the estimated samples. The collected data entered into Epi-data 3.1 and analyzed using SPSS version 21. Descriptive statistics were computed. Simple logistic analysis was run (at 95% CI and p-value < 0.05) to identify factors associated with non-Hodgkin’s lymphoma.Result: A total of 486 patients participated. Larger portion of cases (34%) and controls (35.2%) were in the age group of 46-60 years. About 90% of cases and 91% of controls were Orthodox Christian. Having monthly income of < 28 dollar [AOR=2.73; 95% CI (1.8, 4.2)], being male sex [AOR=1.8; 95% CI (1.2, 2.8)], ever had chemical exposure, [AOR=11.9; 95% CI (7.6, 18.8)], had no regular physical exercise [AOR=15.5, 95% CI (5.7, 42.3)] and having hypertension [AOR=0.03; 95% CI (0.005,0.2)], lung disease (COPD) [AOR=0.2; 95% CI (0.06, 0.7)], and other health problems [AOR=0.06; 95% CI (0.01, 0.2)] were the identified root causes for non-Hodgkin’s lymphoma.Conclusions Having low monthly income, being male sex, ever had chemical exposure, not engaged in regular physical exercise and being diabetic patient was at an increased risk for non-Hodgkin’s lymphoma.
Current status of the clinical use of PD-1/PD-L1 inhibitors: a questionnaire survey of oncologists in China
Authors: Zhang Bicheng , Song Yuxiao , Fu Yang , Zhu Bo , Wang Baocheng , Wang Jun
Published: November 2019

Objective : The purpose of the present study was to obtain information on the use of PD-1/PD-L1 inhibitors by oncologists in China through a national questionnaire survey. Materials and Methods : Between the 7th and 25th of July in 2019, a questionnaire designed by the Chinese Society of Clinical Oncology Immuno-Oncology (CSCO-IO) Committee on the current status of the use of PD-1/PD-L1 inhibitors was distributed online and offline to cancer-related medical departments in thirty different provinces and autonomous regions of China. The national questionnaire consisted of three sections as follows: general information, current status of the application of PD-1/PD-L1 inhibitors in the clinic, and oncologists’ concerns regarding utilization. Results : The valid response rate of the current status survey was 76.3%. The proportion of senior doctors (physician-in-charge or a more superior position for more than three years) among the respondents was relatively high (67.0% in 588). Ofthe respondents,59.2% had prescribed PD-1/PD-L1 inhibitors during clinical treatment, and the most frequent reason for not prescribing these inhibitors was the choice "do not understand the mechanism and the efficacy of PD-1/PD-L1 inhibitors". In addition, 77.9% of the prescribers used the medications in an off-labelsituation, and the most important motivation for this use was the fact that "there were indications abroad but not domestically". In addition, 77.9% of the prescribers believed that “immunotherapy-related adverse effects could be controlled or intervened through follow-up management”. The prescribers were mostly concerned about "how to identify pseudoprogression and hyperprogression" and "immunity-related adverse effects management". Conclusion : The present study highlights the current status of PD-1/PD-L1 inhibitors in China. Increasing numbers ofmedical oncologists are interested in PD-1/PD-L1 inhibitors, andthey are in need of immunotherapyeducation.
MR Imaging Features of Orbital Langerhans Cell Histiocytosis
Authors: Author) chunnan wu(Former Corresponding , li kuncheng , Hei yan , lan pengyu , Author) xuetao Mu(New Corresponding
Published: November 2019

Background: To investigate the magnetic resonance imaging (MRI) features of orbital Langerhans cell histiocytosis (LCH) to improve diagnostic accuracy. Methods: We retrospectively reviewed clinical manifestations and MRI findings of 23 patients with histopathology-confirmed LCH of the orbit. The findings were evaluated for the following: (a) symptoms, (b) disease duration，(c) location, (d) configuration, (e) margin, (f) MR imaging signal intensity and enhanced performance. Results: Eighteen patients (78%) in our series were male, only five (22%) patients were female, and the mean age at presentation was 6.3 years. The common symptoms include swollen eyelids, exophthalmos, and a palpable mass. Fourteen patients presented with swollen eyelids and/or exophthalmos. Twenty-two cases involved unilateral orbits, and one case involved bilateral orbits. In our study, there was one patient with cough and expectoration, and one patient with polydipsia and polyuria. Lesions were located in the superior or superlateral orbital roof of seventeen patients (74%). Lesions formed masses or irregular shapes. The 12 out of 23 (52.2%)cases appeared heterogeneous isointense and 10 out of 23 (43.5%) cases showed iso-hypointense on T1-weighted imaging, there were 15 out of 23 (65.2%) cases showed hyper-hypointense mixed signals on T2-weighted imaging. 7 cases found patchy hyperintense signal on T1WI, and 11 cases showed markedly hyperintense signal near the edge of lesions on T2WI. After enhancement, 21 out of 23 (91.3%) cases lesions presented marked enhancement at the edges and the surrounding tissues, and with heterogeneous obvious enhancement of the lesion center. Besides, four cases lesions were surrounded by a low circular signal. Conclusion: There were several characteristics MRI features that can provide crucial information for clinicians and improve our understanding and the diagnostic accuracy of the orbital LCH.
Study On the Effectiveness and Safety of Foldable Capsular Vitreous Body Implantation
Authors: Zhang Xiangyang , Tian Xuemin , Zhang Baike , Guo Lisa , Li Xiaodan , Jia Yong
Published: November 2019

Background: To investigate theefficacy and safety of the foldable capsular vitreous body(FCVB) in the treatment of vitreoretinal diseases. Methods: A retrospective analysis was conducted involving 20 patients (20 eyes) who underwent FCVB implantation in our hospital from September 2017 to April 2018. All the patients underwent vitrectomyand FCVB implantation, a standard three-port vitrectomy was performed, and the FCVB was implanted into the vitreous cavity. At 6 months after surgery, the visual acuity chart, Goldmann applanation tonometer, fundus photography, B-ultrasound examination, and optical coherence tomography (OCT) examination were performed on the treated eyes.The patients’ vision, intraocular pressure, retinal reattachment, and FCVB status were observed. Results: Compared with the preoperative measurements, there was no change in visual acuity in 18 eyes at 6 months after FCVB implantation, and the difference was not significant (P=1.000); the intraocular pressure of these 18 eyes returned to normal, and the difference was significant (P=0.00001); in fundus photographyimages of these 18 eyes, B-ultrasound,OCT showed good retinal reattachment, FCVB distributed well in the vitreous cavity and evenly supported the vitreous retina and there was no obvious abnormality. The eyes were symmetrical, and the eyeball activity was normal. One patient developed eyeball atrophy after surgery, and one patient developed ocular inflammation after surgery. The condition improved after treatment. Conclusions: FCVB is an effective and safe vitreous substitute during the 6-month implantation period and is able to maintain eye shape, intraocular pressure and good aesthetics.
Purtscher-like retinopathy presented a honeycomb-like pattern in optical coherence topography angiography
Authors: Li Bing , Chen Youxin , Li Donghui
Published: November 2019

Background: To report a case of Purtscher-like retinopathy (PUR) and the optical coherence tomography (OCT) and OCT angiography (OCT-A) findings before and after treatment. Case presentation: A 65-year-old male presented with acute onset of vision loss for 2 weeks. Fundus examination revealed cotton-wool spots, retinal haemorrhage, and Purtscher flecken spread around the optic disc in the right eye. He was diagnosed with Purtscher-like retinopathy because he lacked any traumatic medical history. OCT presented some band-like hyperreflective lesions at the inner nuclear layer, which are indicative of paracentral acute middle maculopathy (PAMM). OCT-A revealed apparent reduction in blood flow signal at the deep retina and choriocapillaris layers with a honeycomb-like hypointense signal pattern. After 3 months of follow-up, OCT revealed resolution of retinal oedema, but PAMM lesions remained visible. Based on OCT-A, the honeycomb-like pattern turned into a homogeneous reduction in blood flow with small patches of hypointense signal areas in the choriocapillaris. Conclusion: This case presented a new OCT-A sign in PUR with a honeycomb-like hypointense signal at the choriocapillaris layer, indicating the involvement and ischaemia of the choroid during the pathological process.
Hoax di Media Sosial Facebook: Antara Edukasi dan Propaganda Kepentingan
Authors: Nugraha Muhamad Tisna
Published: November 2019

Technological advances have encouraged the raise of a variety of social media services features which are more and more innovative, interesting, and variative. This technological development impacting in human civilization, especially pertaining to multidimensional as well as multilateral interaction. The benefit of social media was accompanied by the negative side, such as slander, conflict, nation- disintegration, and separatism. This is a qualitative research applying case- study approach. The instruments used in this research are documentation, observation, and library research. The conclusion is that education has an important role in using social media. Otherwise, social media will only be used as the media for committing crime, including disseminating tendentious words, hoax, and propaganda
SUFISTIC THERAPY WITH SPIRITUAL EMOTIONAL FREEDOM TECHNIQUE (SEFT) METHOD FOR HEALING THE BEHAVIOR OF DRUGS ADDICT
Authors: Farmawati Cintami
Published: November 2019

This research is to find out whether Sufistic therapy with the Spiritual Emotional Freedom Technique (SEFT) method can cure the behavior of addicts who seek drugs. Research subjects were 4 (four) drug addicts. The physical dependence on drugs that can be overcome by providing drugs with groups as substances commonly consumed to minimize them, but the hardest thing is to change the behavior of addicts who are looking for drugs and consume them again. This study uses a multiple baseline design with AB follow-up design where A is the baseline, B is a Sufistic therapy with SEFT method which allows the stages of set-up, tune in, and tapping, as well as follow-up. Data analysis in this study uses quantitative analysis and qualitative analysis. The quantitative analysis in this study is in the form of graphical explanations of research, while the qualitative analysis is the result of observations and interviews during the research. The results of this study indicate that the hypothesis is accepted where Sufistic therapy with the SEFT method can cure the behavior of addicts who seek drugs.
Mardin İli Zeytin Bahçelerinde Zararlı Böcek Türleri, Yayılışları ve Yoğunlukları
Authors: KAPLAN Mehmet
Published: November 2019

Bu çalışma, Mardin ili Merkez'e bağlı Dara köyü ile Derik, Nusaybin ve Kızıltepe ilçelerindeki zeytin bahçelerinde bulunan zararlı böcek türlerini belirlemek amacıyla 2014-2015 yıllarında yürütülmüştür. Örneklemeler, kimyasal girdilerin (pestisit, gübre vs.) uygulanmadığı her biri en az 30–40 adet zeytin ağacına sahip olan 8 farklı bahçede yapılmıştır. Örneklemelerde eşeysel çekici tuzaklar, görsel renk tuzakları, darbe yöntemi, gözle kontrol yöntemi ve laboratuvar çalışmalarında da kültüre alma yöntemi uygulanmıştır. Bu çalışma sonucunda 4 takıma bağlı 7 familyaya ait toplam 7 adet zararlı böcek türü tespit edilmiştir. Belirlenen bu türlerden, zeytin bahçelerinde zararlı olan Euphyllura straminea Loginova (Hem.:Psyllidae), Prays oleae Bern.(Lepidoptera: Praydidae), Closterotomus (Calocoris) trivialis Costa (Hemiptera: Miridae), Bactrocera oleae Gmel (Diptera: Tephritidae) ve Phloeotribus scarabaeoides Bernard (Coleoptera: Curculionidae)' in oluşturdukları zarar, yayılış ve yoğunluk açısından birinci derecede zararlı türler oldukları belirlenmiştir. Bu türlerin dışında Parlatoria oleae Colvee (Hemiptera, Diaspididae) ve Agalmatium flavescens Oliver (Hemiptera: Issidae) türlerinin ise zeytin bahçelerinde düşük yoğunlukta bulunan ikinci derecede zararlılar olduğu saptanmıştır.
Süt Endüstrisi Atıksularının Kimyasal Arıtımının Yanıt Yüzey Yöntemi ile Optimizasyonu
Authors: OZMETİN Elif
Published: November 2019

Bu çalışmada, yüksek kirletici yükleri ile karakterize edilen süt endüstrisi atıksularının kimyasal arıtımı amaçlanmıştır. Arıtımda koagülant olarak demir III klorür (FeCl3.6H2O) ve alüminyum sülfat (Al2(SO4)3.18H2O) kullanılmış, her iki koagülant için optimizasyon metodu olarak yanıt yüzey yönteminin (YYY) merkezi kompozit tasarımı (MKT) uygulanarak atıksudan kimyasal oksijen ihtiyacı (KOİ) ve askıda katı madde (AKM) giderimleri incelenmiştir. Yöntem yardımıyla KOİ ve AKM giderim verimlerinin hesaplanabileceği denklemler elde edilmiş, arıtma prosesini etkileyen en önemli parametreler ortaya konularak giderimleri maksimum yapan şartlar belirlenmiştir. Demir III klorür ile yapılan çalışmalarda KOİ ve AKM giderim verimlerini maksimum yapan şartlar; pH: 7.41, doz: 158.579 mg L-1 elde edilmiş ve bu şartlarda KOİ ve AKM giderim verimleri sırasıyla %80.84 ve %98.10 olmuştur. Alüminyum sülfat (alüm) ile yapılan çalışmalarda KOİ ve AKM giderim verimlerini maksimum yapan şartlar; pH: 7.29, doz: 197.475 mg L-1 elde edilmiş ve bu şartlarda KOİ ve AKM giderim verimleri ise sırasıyla %73.33 ve %96.21 olmuştur.
Pollen and Seed Micromorphology of the some Erodium L’Herit (Geraniaceae) Species in Hatay Province
Authors: İLÇİM Ahmet , GÜNENÇ Meryem , KARAHAN Faruk
Published: November 2019

In this study, pollen and seed micromorphology of 7 naturally distrubuted Erodium species (E. acaule, E. amanum, E. botrys, E. cucitarium, E. gruinum, E. malacoides and E. moschatum) in Hatay Province (Turkey) have been studied. Palynological analysis showed that pollen grains were generally medium, spheroidal and spheroidal subprolate, radially symmetrical, tricolporate and reticulate-clavate ornamentation. The seed characters were found ovate-eliptic and oblanceolate in shape, with rugose-foveate, reticulate-foveate and bireticulate-foveate ornamentation. The results demonstrated that characters such as pollen size, pollen shape, seed size, seed shape, seed surface ornamentation and seed cell pattern were found important and useful for the identification of Erodium species investigated.
Kinetics, Isotherm and Thermodynamic Studies of The Adsorption Behavior of Basic Yellow 51 Onto Rice Husk and Burned Rice Husk
Authors: BAYRAK TEZCAN Elif , CEYLAN Zeynep , ACAR Filiz Nuran
Published: November 2019

In this work, rice husk and burned rice husk were used as low cost adsorbents to remove a cationic dye, Basic Yellow 51(BY51) , from aqueous solution by adsorption. Characterization of rice husk and burned rice husk was carried out with Scanning Electron Microscope and Fourier Transform Infrared Spectroscopy. The effects of operational parameters on the efficiency of dye removal including initial dye concentration, contact time, pH, and temperature were investigated. All series experiments were carried out in batch mode. Equilibrium data were analyzed using Langmuir and Freundlich isotherm models and monolayer adsorption capacity was calculated. Kinetic data were studied using pseudo first order and pseudo second order kinetic models and dye removal was found to follow the pseudo second order kinetic model closely. Thermodynamic parameters such as enthalpy change (H°), entropy change (S°) and free energy change (G°) were also investigated. Free energy change showed that adsorption of Basic Yellow 51 was spontaneous at all studied temperatures for rice husk and burned rice husk. It is proposed that rice husk and burned rice husk may be suitable as adsorbents for removal of cationic dyes from aqueous solution.
Use of diluted poultry manure as a low-cost emulsifier for anaerobic digestion of used cooking oil
Authors: Eftaxias Alexandros , Gkalimanis Prodromos , Koskinari Maria Dolores , Koumara Alexandra , Diamantis Vasileios , Aivasidis Alexandros
Published: November 2019

The aim of this study was to evaluate the anaerobic co-digestion of diluted poultry manure (DPM) and used cooking oil (UCO). Mixtures of DPM with different UCO dosages (1 to 6% v/v) were prepared using a high-shear emulsifier and digested in batch anaerobic reactors. Increasing the UCO dosage increased the emulsion COD (from initially 64 to 182 g · L−1) but emulsion stability was affected adversely. UCO at the optimum dosage (1.5 to 2.0% v/v) was further digested in a semi-continuous mesophilic anaerobic reactor, to assess process feasibility at organic loading rates (OLRs) up to 8 g · L−1 · d−1. The reactor was stable, yielding biogas at 0.45 L · g−1 COD, with low supernatant COD (<6 g · L−1), negligible VFA accumulation and no foaming.
Short-term flexibility for energy grids provided by wastewater treatment plants with anaerobic sludge digestion
Authors: Schäfer M.
Published: November 2019

For a sustainable development of the energy sector – in the future – an additional potential of energetic flexibility as well as storage capacities will be required to compensate for fluctuating renewable energy production. The operation of energy systems will change and flexibility in energy generation and consumption will rise to become a valuable asset. Wastewater treatment plants (WWTPs) with anaerobic sludge digestion are capable of providing that needed flexibility, not only with their energy generators but also in terms of their energy consuming aggregates on the plant. Under these circumstances a methodical approach has been developed that can be used to select, evaluate and safely implement typical aggregates on WWTPs for flexible plant operation and the provision of energetic flexibility. Relevant key figures have been developed that reconcile requirements of the purification processes with technical-physical necessities as well as the demands of the energy market. Furthermore, restrictions and control parameters have been established which complement the developed key figures to ensure effluent quality. It was demonstrated that WWTPs are able to adapt their operation mode to external and internal requirements under controlled conditions. The existing flexibility is suitable for a variety of uses, and WWTPs in general are able to participate in today's and in future energy supply products and new business models. The results show that WWTPs have a significant potential to produce renewable energy and to provide energetic flexibility, which is needed to stabilize future renewable-energy-driven energy grids.
O Selo de Qualidade ABEOC BRASIL e a sua aplicabilidade às organizadoras de eventos em Pernambuco, Brasil
Authors: Belchior Maria Helena
Published: November 2019

O estudo apresentado versa quanto à conhecer o selo de qualidade proposto pela Associação Brasileira de Empresas de Eventos (ABEOC). Pautou-se em métodos e técnicas concernentes à pesquisa de caráter descritivo, do tipo mista, utilizando-se como meios necessários à coleta de dados a entrevista semiestruturada, aplicação de questionários e realização de pesquisa documental. A criação do “Selo de Qualidade ABEOC Brasil”, de 2012 até 2015, contou com 236 empresas inscritas, das quais 225 participaram da etapa referente à aplicação e análise de avaliação diagnóstica. Destas, 99 estiveram aptas à realizar avaliação de conformidade para obtenção do selo sendo um total de 97 habilitadas ao recebimento, sete do estado de Pernambuco. Todo procedimento voltado à conquista do “Selo de Qualidade ABEOC Brasil” pelas empresas do setor de Eventos centrou-se, em aspectos gerais, nas etapas de avaliação diagnóstica preliminar, preparação das empresas para recebimento da auditoria e análise do grau de conformidade aos documentos base de avaliação sendo o processo conduzido por empresas específicas para tal fim. Como resultados nacionais identificou-se o alcance das metas previamente estabelecidas específicas a novas práticas de gestão, adesão das empresas à certificação, obtenção do selo e aumento de faturamento durante a execução do projeto. Verificou-se ainda a necessidade de avaliação acerca dos resultados percebidos à luz das empresas participantes em Pernambuco de modo a se equacionar questões envoltas à publicidade e a ampliação da divulgação dos benefícios intrínsecos àqueles que submeteram à certificação para um melhor atendimento, qualidade nos serviços prestados e ampliação de clientela.

Palavras-chave: ABEOC. Selo de Qualidade. Organizadoras de Eventos. Pernambuco.
Carnatal: A criatividade como ferramenta propulsora do turismo de eventos
Authors: Brito Gildygleide , Ferreira Lissa Valéria Fernandes
Published: November 2019

O artigo trás reflexões sobre a relação entre os elementos criativos utilizados na projeção do Carnatal, assim como os identificados na realização do evento e sua potencialidade como produto turístico. Aponta o processo de estímulo da criatividade dos indivíduos que compõem a Destaque Promoções, empresa organizadora do evento e identifica os componentes capazes de proporcionar uma nova roupagem ao Carnatal, trazendo assim propostas inovadoras para sanar problemas recorrentes, assim como revestir a festividade com uma atmosfera intangível e repleta de subjetividade. Destaca o processo evolutivo do evento e as inovações incrementais aplicadas, da mesma maneira que contextualiza a empresa organizadora do evento. Apresenta dados que corroboram com a premissa do Carnatal como importante produto turístico da cidade de Natal/RN. Conclui que o turismo de eventos muito se beneficia com a realização anual do evento, todo o trade turístico local é atingido de forma positiva, à marca da cidade Natal é disseminada, o que leva a entender que o Carnatal desponta e se mantém não apenas como parte de um produto turístico maior, mas revela-se como o próprio.

Palavras-chave: Micareta. Carnatal. Turismo de Eventos. Criatividade.
A Review of the Role of Amelogenin Protein in Enamel Formation and Novel Experimental Techniques to Study its Function
Authors: Ali Saqib , Farooq Imran
Published: November 2019

:

Amelognein protein plays a vital role in the formation and mineralization of enamel matrix. Amelogenin structure is complex in nature and researchers have studied it with different experimental techniques. Considering its important role, there is a need to understand this important protein, which has been discussed in detail in this review. In addition, various experimental techniques to study amelogenin protein used previously have been tackled along with their advantages and disadvantages. A selection of 67 relevant articles/book chapters was included in this study. The review concluded that amelogenins act as nanospheres or spacers for the growth of enamel crystals. Various experimental techniques can be used to study amelogenins, however, their advantages and drawbacks should be kept in mind before performing analysis.
Nε-Acetyl L-α Lysine Improves Activity and Stability of α-Amylase at Acidic Conditions: A Comparative Study with other Osmolytes
Authors: Joghee Nidhya N. , Jayaraman Gurunathan , Selladurai Masilamani
Published: November 2019

Background:

Nε-acetyl L-α lysine is an unusual acetylated di-amino acid synthesized
and accumulated by certain halophiles under osmotic stress. Osmolytes are generally known to
protect proteins and other cellular components under various stress conditions.

Objective:

The structural and functional stability imparted by Nε-acetyl L-lysine on proteins were
unknown and hence was studied and compared to other commonly known bacterial osmolytes -
ectoine, proline, glycine betaine, trehalose and sucrose.

Methods:

Effects of osmolytes on the temperature and pH profiles, pH stability and thermodynamic
stability of the model enzyme, α-amylase were analyzed.

Results:

At physiological pH, all the osmolytes under study increased the optimal temperature for
enzyme activity and improved the thermodynamic stability of the enzyme. At acidic conditions (pH
3.0), Nε-acetyl L-α lysine and ectoine improved both the catalytic and thermodynamic stability of
the enzyme; it was reflected in the increase in residual enzyme activity after incubation of the
enzyme at pH 3.0 for 15 min by 60% and 63.5% and the midpoint temperature of unfolding
transition by 11°C and 10°C respectively.

Conclusion:

Such significant protective effects on both activity and stability of α-amylase imparted
by addition of Nε-acetyl L-α lysine and ectoine at acidic conditions make these osmolytes
interesting candidates for biotechnological applications.
Gut-Amygdala Interactions in Autism Spectrum Disorders: Developmental Roles via regulating Mitochondria, Exosomes, Immunity and microRNAs
Authors: Seo Moonsang , Anderson George
Published: November 2019

Background:

Autism Spectrum Disorders (ASD) have long been conceived as developmental disorder. A growing body of data highlights a role for alterations in the gut in the pathoetiology and/or pathophysiology of ASD. Recent work shows alterations in the gut microbiome to have a significant impact on amygdala development in infancy, suggesting that the alterations in the gut microbiome may act to modulate not only amygdala development but how the amygdala modulates the development of the frontal cortex and other brain regions.

Methods:

This article reviews wide bodies of data pertaining to the developmental roles of the maternal and foetal gut and immune systems in the regulation of offspring brain development.

Results:

A number of processes seem to be important in mediating how genetic, epigenetic and environmental factors interact in early development to regulate such gut-mediated changes in the amygdala, wider brain functioning and inter-area connectivity, including via regulation of microRNA (miR)-451, 14-3-3 proteins, cytochrome P450 (CYP)1B1 and the melatonergic pathways. As well as a decrease in the activity of monoamine oxidase, heightened levels of in miR-451 and CYP1B1, coupled to decreased 14-3-3 act to inhibit the synthesis of N-acetylserotonin and melatonin, contributing to the hyperserotonemia that is often evident in ASD, with consequences for mitochondria functioning and the content of released exosomes. These same factors are likely to play a role in regulating placental changes that underpin the association of ASD with preeclampsia and other perinatal risk factors, including exposure to heavy metals and air pollutants. Such alterations in placental and gut processes act to change the amygdala-driven biological underpinnings of affect-cognitive and affect-sensory interactions in the brain.

Conclusion :

Such a perspective readily incorporates previously disparate bodies of data in ASD, including the role of the mu-opioid receptor, dopamine signaling and dopamine receptors, as well as the changes occurring to oxytocin and taurine levels. This has a number of treatment implications, the most readily applicable being the utilization of sodium butyrate and melatonin.
Effects of Aging and Diet on Cardioprotection and Cardiometabolic Risk Markers
Authors: Corina Andreea , Abrudan Maria B. , Nikolic Dragana , Cӑtoi Adriana F. , Chianetta Roberta , Castellino Giuseppa , Citarrella Roberto , Stoian Anca P. , Pérez-Martínez Pablo , Rizzo Manfredi
Published: November 2019

The prevalence of several diseases increases by age, including cardiovascular diseases, which are the
leading cause of morbidity and mortality worldwide. Aging, as a complex process characterized by senescence,
triggers various pathways, such as oxidative stress, systemic inflammation, metabolism dysfunction, telomere
shortening, mitochondrial dysfunction and deregulated autophagy. A better understanding of the mechanisms
underlying senescence may lead to the development of new therapeutic targets and strategies for age-related
pathologies and extend the healthy lifespan. Modulating lifestyle risk factors and adopting healthy dietary patterns
remain significant tools in delaying the aging process, decreasing age-associated comorbidities and mortality,
increasing life expectancy and consequently, preventing the development of cardiovascular disease. Furthermore,
such a strategy represents the most cost-effective approach, and the quality of life of the subjects may be
significantly improved. An integrated, personalized approach targeting cardiometabolic aging and frailty is suggested
in daily clinical practice. However, it should be initiated from an early age. Moreover, there is a need for
further well designed and controlled studies in order to elucidate a link between the time of feeding, longevity and
cardiovascular prevention. In the future, it is expected that the pharmacological treatment in cardioprotective
management will be necessary, accompanied by equally important lifestyle interventions and adjunctive exercise.
Epidemiology and Risk Factors for Severe Delayed Drug Hypersensitivity Reactions
Authors: Gomes Eva S.R. , Marques Maria L. , Regateiro Frederico S.
Published: November 2019

:

Severe delayed drug hypersensitivity reactions comprise different clinical entities and can involve different immune medSevere delayed drug hypersensitivity reactions comprise different clinical entities and can involve different immune-mediated mechanisms. Common examples are severe cutaneous adverse reactions and druginduced internal organ injuries.iated mechanisms. Common examples are severe cutaneous adverse reactions and drug induced internal organ injuries. The incidence of such reactions is overall low but seems to be on the rise reaching numbers as high as 9 per million individuals-years in the case of SJS/TEN and in DRESS. Such conditions carry an important associated morbidity, and mortality can attain 40% in SJS/TEN patients, making these hypersensitivity reactions important targets when implementing preventive measures. Several risk factors have been identified, some being transverse, for reactions severity as older age and underlying chronic diseases. The recent advances in pharmacogenetics allowed the identification of specific populations with higher risk and permitted strategic avoidance of certain drugs being HLA-B*57:01 screening in patients initiating abacavir the best successful example. In this work we reviewed the epidemiology of SCARs and liver/kidney/lung drug induced immune-mediated reactions. We focus in particular aspects such as prevalence and incidence, drugs involved, mortality and risk factors.

:

The incidence of such reactions is overall low but seems to be on the rise reaching numbers as high as 9 per million individuals-years in the case of SJS/TEN and DRESS. Such conditions carry an important associated morbidity, and mortality can attain 40% in SJS/TEN patients, making these hypersensitivity reactions important targets when implementing preventive measures.

:

Several risk factors have been identified for reaction severity; some are transverse, such as older age and underlying chronic diseases. The recent advances in pharmacogenetics allowed the identification of specific populations with higher risk and permitted strategic avoidance of certain drugs being HLA-B*57:01 screening in patients initiating abacavir the best successful example. In this work, we reviewed the epidemiology of SCARs and liver/kidney/lung drug-induced immune-mediated reactions. We focus on particular aspects such as prevalence and incidence, drugs involved, mortality and risk factors.
Moringa Oleifera in Malnutrition: A Comprehensive Review
Authors: Mushtaq Bilal Sajid , Hussain Muhammad Bilal , Omer Rabia , Toor Hafiz Ahmad , Waheed Marwa , Shariati Mohammad Ali , Sergey Plygun , Heydari Mojtaba
Published: November 2019

Nutritional deficiency is a major concern in developing countries, resulting in serious
health consequences like mental and physical growth retardation. Moringa oleifera (Moringa), a
nutritious plant growing in tropical regions of developing countries, is a candidate for overcoming
nutritional deficiency. Moringa leaves are rich in protein including sulphur containing amino acids.
It contains high amounts of vitamin C than oranges, a higher concentration of vitamin A than carrots,
higher calcium content than milk and more potassium than bananas. Moreover, there is 9
times more iron in moringa than spinach and 4 times more fiber than oats. This review enlightens
and explores the nutritional diversification of Moringa oleifera and other benefits which make it a
better choice to use in our daily diet to combat malnutrition.
Diabetes, Diabetic Complications, and Phosphate Toxicity: A Scoping Review
Authors: Brown Ronald B.
Published: November 2019

This article presents a scoping review and synthesis of research findings investigating the toxic cellular accumulation of dysregulated inorganic phosphate—phosphate toxicity—as a pathophysiological determinant of diabetes and diabetic complications. Phosphorus, an essential micronutrient, is closely linked to the cellular metabolism of glucose for energy production, and serum inorganic phosphate is often transported into cells along with glucose during insulin therapy. Mitochondrial dysfunction and apoptosis, endoplasmic reticulum stress, neuronal degeneration, and pancreatic cancer are associated with dysregulated levels of phosphate in diabetes. Ectopic calcification involving deposition of calcium-phosphate crystals is prevalent throughout diabetic complications, including vascular calcification, nephropathy, retinopathy, and bone disorders. A low-glycemic, low-phosphate dietary intervention is proposed for further investigations in the treatment and prevention of diabetes and related diabetic pathologies.
ConvsPPIS: Identifying Protein-protein Interaction Sites by an Ensemble Convolutional Neural Network with Feature Graph
Authors: Zhu Huaixu , Du Xiuquan , Yao Yu
Published: November 2019

Background/Objective:

Protein-protein interactions are essentials for most cellular
processes and thus, unveiling how proteins interact with is a crucial question that can be better
understood by recognizing which residues participate in the interaction. Although many
computational approaches have been proposed to predict interface residues, their feature
perspective and model learning ability are not enough to achieve ideal results. So, our objective is
to improve the predictive performance under considering feature perspective and new learning
algorithm.

Method:

In this study, we proposed an ensemble deep convolutional neural network, which
explores the context and positional context of consecutive residues within a protein sub-sequence.
Specifically, unlike the feature view of previous methods, ConvsPPIS uses evolutionary,
physicochemical, and structural protein characteristics to construct their own feature graph
respectively. After that, three independent deep convolutional neural networks are trained on each
type of feature graph for learning the underlying pattern in sub-sequence. Lastly, we integrated
those three deep networks into an ensemble predictor with leveraging complementary information
of those features to predict potential interface residues.

Results:

Some comparative experiments have conducted through 10-fold cross-validation. The
results indicated that ConvsPPIS achieved superior performance on DBv5-Sel dataset with an
accuracy of 88%. Additional experiments on CAPRI-Alone dataset demonstrated ConvsPPIS has
also better prediction performance.

Conclusion:

The ConvsPPIS method provided a new perspective to capture protein feature
expression for identifying protein-protein interaction sites. The results proved the superiority of
this method.
Effects of the Sea Breeze Circulation on Soil Temperature Over Kuwait Using in Situ Observations and the ECMWF Model
Authors: Alsarraf Hussain , Broeke Matthew V.D. , Aljassar Hala
Published: November 2019

Background:

The mesoscale circulation over Kuwait is an important influence on changes in surface temperatures and soil temperatures.

Introduction:

This paper presents two common summertime atmospheric features over Kuwait linking wind circulation to soil temperatures.

Methods:

In this study, we use the European Centre for Medium-range Weather Forecasts ECMWF reanalysis ERA-Interim dataset to investigate effects of the synoptic scale and mesoscale circulations.

Results:

The results show that a large-scale pressure gradient in summer typically leads to northerly winds over Kuwait, while a weak synoptic-scale pressure gradient leads to light easterly humid winds from the Persian Gulf, consistent with a mesoscale circulation.

Conclusions:

The results demonstrate the significance of wind circulations in driving the Soil Temperature (SOILT). Using the Era-Interim/Land reanalysis dataset for August 2015 over Kuwait, the average SOILT on days of sea breeze is higher than the average SOILT on days dominated by a synoptic-scale pressure gradient.
Tradición y cambios en las políticas urbanas y la conservación del patrimonio edificado en el barrio de San Pedro del Centro Histórico de Cusco, durante la gestión municipal 2011-2014
Authors: Fernández Díaz Pedro , Quispe Callo Víctor , Pacheco Huacac Yoni , Vicente Pastor María , Espinoza Lara Silvia , Álvarez Tito Kenny
Published: November 2019

El presente trabajo se centra en las herramientas más destacables que se han empleado para la protección y gestión del patrimonio cultural en el tradicional barrio de San Pedro, ubicado en el lado suroeste del Centro Histórico del Cusco. Se analizan los diferentes planes de desarrollo urbano aplicados en la ciudad del Cusco; las políticas del INC; misiones como la Misión Kubler, que se limitan a impartir recomendaciones para la conservación y protección de los inmuebles prehispánicos y virreinales. Además, se aborda una experiencia de Cooperación Técnica Internacional, que se practicó en la manzana No. 127; los trabajos de la ONG Guamán Poma de Ayala y la World Monument Watch, rehabilitando casonas y viviendas para mejorar el nivel de vida de 302 habitantes. Se analiza la gestión municipal de la provincia del Cusco, período 2011-2014, que inició la actualización de tres documentos: el Plan Maestro del Centro Histórico del Cusco, el Catastro Urbano, y Gestión y Manejo del Centro Histórico, que ha resultado ser un registro y catalogación de inmuebles y ambientes urbanos, y obras ejecutadas en la gestión 2011-2014 para el mejoramiento de la transitabilidad vehicular en las calles de Arcopata, Meloc, Avenida Alta, Avenida Baja, Vitoque y Nueva Baja. Finalmente, se identifican las distintas problemáticas que aquejan al barrio en cuestión, como el comercio ambulatorio, el abandono de casonas coloniales, y la congestión vehicular y peatonal en la plaza. Además, se aborda la discusión sobre a qué entidad corresponde gestionar y manejar el Centro Histórico. A manera de conclusión, se expone una propuesta que reúne conceptos e interrogantes centrales para determinar la conformación de un ente gestor adecuado, que reúna instituciones públicas y privadas bajo el liderazgo de la municipalidad provincial, de forma que cuenten con respaldo político y financiero para realizar sus labores.
Medellín, una ciudad transformada por su gestión. Análisis de la gestión de su Centro Histórico (1990-2015)
Authors: Núñez Coronel Débora
Published: November 2019

El presente documento busca realizar un análisis sobre la gestión de los centros históricos colombianos, cuya relevancia se observa a partir de su eficacia en sus gestiones actuales. La presente investigación tiene como personaje principal a la ciudad de Medellín, donde se han realizado intervenciones específicamente durante los últimos 25 años, desde 1990 hasta el 2015. El análisis está enmarcado en el contexto general del patrimonio dentro de Colombia, y recurre a algunos documentos oficiales del gobierno, así como a análisis de los enfoques políticos y patrimoniales, los cuales sirven como base para realizar las estrategias asumidas por el Estado. Todos estos documentos, a partir de los cuales se elaboraron las políticas locales de Medellín, se revisan aquí con el fin de poder conocer a profundidad las estrategias en cuestión. Fue necesaria también la revisión del Plan de Ordenamiento Territorial (POT) local, el cual busca la conservación del patrimonio y el desarrollo de las ciudades, articulado al Plan de Desarrollo Municipal (PDM), parte de la estrategia del gobierno para la mejora integral de los barrios.