bluuebunny/crossref_metadata_2025 huggingface dataset:
Perception of the Health-care Providers toward Telemedicine Practice: A Cross-sectional Study from Karnataka, India
Authors: Davalagi Shubha Bakkappa , Kasturi Eshwar S. , Nayak P Vaman , Ghose Anisha
Published: November 2023

Introduction:

The major advantages of telemedicine can be saving time, cost, and effort, especially for rural patients, during challenging times such as COVID for obtaining consultation and treatment. Telemedicine, if properly implemented, can reduce gaps and strengthen the health-care delivery system in India.

Objective:

The objective of the study was to assess the perception and practice of health-care providers toward telemedicine.

Methodology:

We conducted a cross-sectional study among 141 health-care providers who ever practiced telemedicine consultation. Utilizing online Google Forms, we used snowball sampling. Four sections made up the pretested study questionnaire: demographic information, perceptions, and practices. Statistical Package for the Social Sciences (SPSS) version 21 was used for data analysis.

Results:

Among them, majority were aged between 35 and 44 years (49.6%), males (56%), had M.D./M.S. degree (57.4%), postgraduates (33.3%), worked in private sector (56.7%), and were from clinical specialty (80.8%) We had majority health-care workers who used telemedicine application for the first time after COVID (80.1%), used only mobile (82.2%), used only one application (83.6%), and gave 5–10 consultations per day (57.4%). Most of our study participants feel teleconsultation takes less time (61.7%), reduces waiting list at medical center (92.9%), has better communication (83.6%), gives better aid during emergency (53.9%), and saves money on transportation (97.1%).

Conclusion:

In this study, we could conclude that most participants started practicing telemedicine post-COVID. Health-care professionals still feel challenging to provide effective patient counseling through telemedicine; moreover, they are benefitted from telemedicine practice.
Use of Morphine in Critically Ill COVID-19 Patients: An Ethics Reflection
Authors: Idiculla Jyothi Mariam , Muralidharan Jananee , Kurpad Sunita Simon
Published: November 2023

The use of Morphine in terminal COVID is different from that in palliative care due to variable nature of the pandemic. In developing countries, the limitations in resources that can arise during a COVID wave, necessitates the availability of national guidelines for terminal care.
A case–control study to assess association of factors with treatment interruption of antiretroviral therapy (ART) among people living with HIV at ART center of tertiary care hospital in Himachal Pradesh, India
Authors: Kumar Dinesh , Raina Sunil K
Published: November 2023

Background:

Treatment interruption affects virologic suppression during antiretroviral therapy (ART) among people living with HIV (PLHIV). The present study was planned to explore factors associated with Loss to follow-up (LFU) among PLHIVs receiving ART from 2017 to 2021 at ART center of tertiary care hospital in Himachal Pradesh.

Materials and Methods:

A case–control study where selected PLHIVs registered with ART center of a tertiary care hospital from 2017 to 2021 were assessed with logistic regression for baseline characteristics and possible reasons for treatment interruption among 120 cases (regular) and 124 controls (missed and LFU).

Results:

Record-based analysis of a total of 703 PLHIV registered at ART center from 2017 to 2021 observed 18.3% LFU of which 70.5% died over 5 years. Adjusted association showed that mean duration of treatment interruption was significantly positively associated with missed (adjusted odds ratio [aOR]: 1.1; 95% confidence interval [CI]: 0.9–1.1), LFU (aOR: 1.1; 95% CI: 1.0–1.2), and combined (missed + LFU) (aOR: 1.1; 95% CI: 1.01–1.2) as compared to regular category. Effect of adverse effects showed a negative significant association with missed (aOR: 0.1; 95% CI: 0.0–0.2) and combined (missed and LFU) (aOR: 0.1; 95% CI: 0.0–0.1) in comparison to regular category.

Conclusions:

ART services need to be made available further down to health care delivery system and closer to place of residence of PLHIV.
Effect of Moringa oleifera Leaf Extract on Glycemic Parameters in Patients with Type 2 Diabetes Mellitus and Prediabetes: A Systematic Review and Meta-analysis
Authors: Kamrul-Hasan A. B. M. , Talukder Samir Kumar , Nagendra Lakshmi , Alam Muhammad Shah , Aalpona Fatema Tuz Zahura , Dutta Deep , Selim Shahjada
Published: November 2023

Background:

Moringa oleiferaleaf (MOL) extract has been used traditionally for treating several diseases, including diabetes mellitus (DM). This study aimed to holistically analyze and summarize the efficacy and safety of MOL extract on glycemic parameters in patients with type 2 DM (T2DM) and prediabetes.

Materials and Methods:

Electronic databases were searched for randomized controlled trials (RCTs) and nonrandomized trials involving patients with T2DM or prediabetes receiving MOL extract in the intervention arm and placebo (or no MOL extract) in the control arm. The primary outcome was the changes in glycemic parameters, for example, hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), and 2-h postprandial plasma glucose (2-h PPG), from the baseline at the end of the trial.

Results:

From 86 initially screened articles, data from 5 studies (3 RCTs and 2 nonrandomized trials) involving 260 subjects were analyzed. Subjects in the MOL extract group had similar reductions in HbA1c (mean difference [MD] −0.11%, 95% confidence interval [CI] [ −0.37, 0.14],P= 0.39,I2= 24% [not important heterogeneity], very low certainty of evidence) and FPG (MD −0.63 mmol/L, 95% CI [−1.89, 0.64],P= 0.33,I2= 94% [high heterogeneity], very low certainty of evidence) than the control group although reductions in 2-h PPG were greater in the MOL extract group (MD −3.46 mmol/L, 95% CI [−4.96, −2.16],P< 0.00001,I2= 0% [not important heterogeneity], very low certainty of evidence). Subjects in the MOL extract group achieved greater systolic and diastolic blood pressure reductions than the control group. No hypoglycemic events were reported in either group.

Conclusion:

Current preliminary data do not support MOL extract’s glucose-lowering efficacy in patients with T2DM and prediabetes.
Transfusion Audit and Targeted Education as Tools to Improve Clinical Practice of Fresh Frozen Plasma Transfusions: An Interventional Study
Authors: Navin Nisha , Shahulhameed Shaiji Panthiyil , Dharmadas Meena
Published: November 2023

Background and Objectives:

The transfusion of fresh frozen plasma (FFP) is an essential modality of treatment but carries a residual risk of transfusion-transmitted infections and other adverse events. Continuous education and promotion of evidence-based practice are essential among clinicians to follow good clinical practices with respect to transfusion. This study aims to assess the impact of transfusion audit and educational interventions on the appropriateness of FFP transfusions with respect to indications, by comparing the proportion of appropriate FFP requests before and after the intervention. The study was an interventional study done on all medical professionals who requested FFP for various reasons from the department of transfusion medicine, for 1 year from April 01, 2011, to March 31, 2012.

Methods:

The study was done in three phases, preintervention audit; intervention including continuous education, one-to-one interactions, and hospital transfusion committee-mediated regulations; and postintervention audit. Statistical analysis was done by SPSS version 16. A paired t-test was used to compare quantitative variables which were continuous. Chi-square test was used for associations in categorical data.

Results:

A total of 3281 units of FFP were transfused in the preintervention period, and 2480 units in the postintervention period. Out of a total of 823 appropriate indications 75.6% indications were definitely indicated in the preintervention period. This increased to 81.8% of total 1290 requests after the intervention. The increase in definite indications was found to be statistically significant.

Conclusion:

Transfusion audits and educational interventions can create an impact on the appropriateness of FFP Transfusions especially if targeted to particular specialties and continued to follow-up.
Daratumumab: A Drug with Transfusion Dilemma
Authors: Biswas Amit Kumar , Gairola Anurag , Baranwal Ajay Kumar , Jagani Rajat , Pawar Amit Ajay , Dimri Ujjwal
Published: November 2023

Daratumumab (DARA) is an anti-CD38 monoclonal antibody which has promising results in relapsed and refractory multiple myeloma (RRMM). DARA interferes with blood compatibility testing by causing incompatible results while crossmatching by antihuman globulin phase and presenting as a panagglutination picture in the indirect antiglobulin test. Immunohematology workup must be done to rule out allo- or autoantibody and to issue compatible unit to the patient as transfusion support is vital for all these patients and must not be delayed. Here, we present a case report of one such patient who was undergoing treatment with DARA for RRMM and had incompatibility found during crossmatching. Out of the available methods to resolve this problem, we utilized the treatment of red cells with 2-mercaptoethanol at our blood center which was effective, time saving, feasible, and less resource demanding. During the progressive course of disease, our patient required transfusion on a regular basis, and we were able to provide compatible units on each instance utilizing the same technique.
Congenital ichthyosis presentation and outcome - A case series
Authors: Ansari Qudsiya A. , Singh Vinaya A. , Randad Kailas G. , Bansal Prasoon
Published: November 2023

The ichthyosis, also called disorders of keratinization or cornification, are heterogeneous group of disorders characterized by a generalized scaling of the skin of varying severity. The majority of ichthyosis is inherited but acquired forms can develop in the setting of malignancy, autoimmune or infectious disease, and nutritional deficiency. Autosomal recessive congenital ichthyosis, which include lamellar ichthyosis, congenital ichthyosiform erythroderma, and harlequin ichthyosis, are rare; their overall incidence has been estimated at approximately 1 in 300,000 births. In this article, we described four cases of congenital ichthyosis, their potential complications, causes of morbidity and mortality, and discussed the management and importance of genetic testing for diagnosis as definitive diagnosis is important for long-term management and counseling of the parents.
Analysis of semen parameters, and hormonal changes of FSH, LH, testosterone, and libido following bariatric surgery
Authors: Javani Siroos , Mosapour Esmaeil , Hoseine Seyedmokhtar , Ashrafi Amir , Farhadi Elham
Published: November 2023

Introduction:

Although studies have shown that bariatric surgery can have a positive effect on the patient's sexual function, there are still disagreements and contradictions in this regard. The present study is aimed to evaluate semen parameters, hormonal changes of FSH, LH, testosterone, and libido following bariatric surgery.

Methods:

The present research as a prospective study was performed on 20 male candidates for bariatric surgery referred to Golestan and Aria hospitals in Ahvaz in 2021. Semen parameters (volume, count, motility, and the percentage of sperm with normal morphology), hormonal profile (including FSH, LH test hormones), and sexual function were evaluated using the International Index of Erectile Function (IIEF-5) questionnaire before and 6 months after the surgery.

Results:

The results of this study indicated that semen parameters did not change significantly 6 months after surgery in comparison with before the surgery (P < 0.05). After the operation, just the total level of testosterone increased significantly (2.23 nmol/L vs. 2.74, P = 0.009). However, LH and FSH levels did not change significantly six months after surgery (P = 0.858 and P = 0.287). The results indicated significant improvement in IIEF score after the operation (P = 0.011).

Conclusion:

The findings of the present study indicated that the decrement of weight as a result of bariatric surgery had a favorable effect on the levels of serum testosterone and sexual performance, while semen parameters did not improve after surgery.
Anthropometric indexes for predicting high blood pressure in Turkish adults
Authors: Canyolu Burcu Aksoy , Şen Nilüfer , Sadıç Beste Özben
Published: November 2023

Purpose:

It is controversial which anthropometric indexes are the best in predicting the risk of hypertension and how anthropometric measurements are related to blood pressure (BP). This study aimed to evaluate the relationship between BP and anthropometric indexes and to determine the best predictors for hypertension risk.

Methods:

This cross-sectional study was conducted with 415 consecutive participants (161 men, mean age: 33.4 years) aged 18–88 years in Istanbul, Turkey. Weight, height, waist circumference (WC), and neck circumference (NC) and BP were measured by well-trained personnel. Waist-to-height ratio (WHtR) and body mass index (BMI) were calculated. Pearson correlation, linear regression, and multivariate analyses were used to assess the relationship between anthropometric measurements and SBP, DBP, using the Statistical Package for the Social Sciences version 23.0.

Results:

The systolic BP (SBP) and diastolic BP (DBP) were related to weight, WC, NC, BMI, and WHtR (P < 0.05). Linear regression analyses showed BMI and WC as independent risk factors for SBP with an increase by 1.11 mmHg in men (P = 0.036) and 1.59 mmHg in women (P = 0.001) in SBP when BMI increased 1 unit, while SBP increases by 0.2 mmHg when WC increases by 1 unit regardless of gender (P = 0.013).

Conclusion:

Our results showed that BMI and WC are related to BP and important predictors of hypertension risk. Therefore, the uses of BMI and WC are recommended as screening tools for the prediction of hypertension risk among Turkish adults.
Elderly awareness and perception of neck femur fracture in Saudi Arabia
Authors: Shehata Shehata Farag , Altalhiyyah Khalid Siraj , Alqahtani Saad Haif , Asiri Abdullah Saad , Alqahtani Faris Saleh M. , Alfarwan Salem Msaoud
Published: November 2023

Background:

Femoral neck fractures are prevalent and make up the highest per cent of proximal femur fractures. The femoral neck is the most common location for a hip fracture. This study aims to assess elderly awareness and perception of neck femur fracture in Saudi Arabia.

Methods:

A descriptive cross-sectional web-based study was conducted targeting all persons aged 60 years or above. An online questionnaire was developed by the study researchers based on literature review and after consultation of the field experts. The anonymous questionnaire was published using the social media platforms from October 2022 to January 2023 by the researchers and their families.

Results:

A total of 410 elderly completed the study questionnaire. Elderly age ranged from 60 to 89 years with mean age of 68.2 ± 10.9 years old. A total of 44 (10.7%) of the study elderly had an overall good awareness regarding NFF. The most reported sources were physician (61.7%), social media (41.2%), mass media (33.4%) and books and magazines reading (20.5%).

Conclusion:

In conclusion, elderly awareness regarding femur neck fracture was very low especially among male elderly and those with no history of trauma. Poor awareness for clinical presentation and complications of NFF was reported.
Use of Systemic Mycophenolate Mofetil Therapy in Ocular Surface Inflammatory Pathologies at the Initiative and Responsibility of the Ophthalmologist
Authors: Furundaoturan Onur , Akçay Pelin , Selver Ozlem B.
Published: November 2023

PURPOSE:

The purpose of the study was to evaluate the efficacy and safety of systemic mycophenolate mofetil (MMF) treatment in ocular surface inflammatory diseases.

METHODS:

For this retrospective study, patients who were treated with systemic MMF for ocular surface inflammatory diseases between March 2020 and March 2022 were evaluated. Apart from demographic data, examination notes including MMF treatment indication and systemic side effect interrogation and routine laboratory examinations during drug treatment were extracted from the patient records. Detailed staging scores were performed according to the diagnosis including Foster and Mondino for ocular mucous membrane pemphigoid (MMP) and limbal stem cell deficiency scoring for limbal transplantation. For thorough evaluation, anterior segment pictures were used.

RESULTS:

Fourteen patients were enrolled to the study, with a mean age of 58 ± 12. MMP (6, 42.8%) and limbal allograft transplantation (6, 42.8%) constituted the main indications for the MMF treatment, followed by keratitis–ichthyosis–deafness (KID) syndrome (1, 7.2%) and Mooren’s ulcer (1, 7.2%). Five of six patients with MMP regressed according to both staging systems. Only one remained stable which was evaluated as Stage 3. Furthermore, while all limbal transplant groups (6) stabilized and showed regression according to the individualized limbal stem cell deficiency staging system with no rejection during follow-up. Furthermore, patients with Mooren’s ulcer and KID syndrome showed control of the inflammation and stabilization after MMF treatment. No significant systemic side effects apart from constipation and nausea (3) were observed in patients whose routine laboratory tests were stable throughout the follow-up.

CONCLUSION:

MMF has the potential to be a valuable and safe systemic agent of first choice in the control of ocular surface inflammatory disorders, especially when topical treatment is not effective. With such studies, it is predicted that MMF may reach wider usage areas with the increase in its effectiveness and safety in its use for ocular surface inflammatory pathologies.
Study the Association between Interleukin-4 Polymorphism and Specific Chlamydia Pneumoniae Immunoglobulin E in Asthmatic Children
Authors: Al-Hasnawy Huda Hadi , Abood Haidar Abdul Amir Najim , Hameed Raghdah Maytham
Published: November 2023

Background:

Asthma is a chronic disorder caused by complex interactions between genetic and environmental influences.

Objective:

Investigate the possible correlation between interleukin-4 (IL-4) gene polymorphisms and development of specific Chlamydia
pneumoniae immunoglobulin (Ig) E levels.

Materials and Methods:

A total of 87 children, including 57 males and 30 females with asthma with ages between 1 and 16 years, attended the Respiratory Clinic at Karbala Pediatric Hospital, with a nonasthmatic children group which have the same age and gender. Restriction fragment length polymerase chain reaction was performed to determine IL-4 C-589T genetic polymorphisms. Total IgE level, C. pneumoniae IgG, and C. pneumoniae IgE antibodies were measured using the commercial quantitative enzyme-linked immunosorbent assay kits.

Results:

C. pneumoniae IgG and IgE antibodies were significantly increased in patients as compared with controls (P < 0.001 and P = 0.024, respectively). The CT genotype of IL-4 C-589T polymorphism was associated with asthmatic children (P < 0.01). A high C. pneumoniae IgE levels were found to be associated with CC genotypes (P = 0.01). On the other hand, there were no significant differences in serum C. pneumoniae IgG levels depending on different IL-4 C589T genotypes (P = 0.662).

Conclusion:

The development of C. pneumoniae IgE antibody in asthmatic children did not depend on IL-4 polymorphism.
Brain drain in medically challenged context: A study of the push, pull, and stick factors among a population of medical practitioners in Nigeria
Authors: Iloh Gabriel Uche , Ikwudinma Augustine Obiora , Obi Ikechukwu Vincent , Akodu Babatunde Abdulmajeed
Published: November 2023

Background:

Globally, brain drain (BD) phenomenon has been an issue for decades in healthcare industry. However, the magnitude of BD syndrome and its impact on medical workforce crisis in a medically challenged environment has been the subject of great interest in the recent years, with apparently glaring effects on the medical workforce.

Aim:

The study was aimed at describing the push, pull, and stick factors, benefits, and preventive measures for BD among medical practitioners in Abia State, Nigeria.

Subjects and Methods:

This was a cross-sectional study carried out on 185 medical practitioners in Abia State, Southeastern Nigeria. Data collection was done using pretested, self-administered, and structured questionnaire that elicited information on push, pull, and stick factors, benefits, and preventive measures for BD. The plan to leave Nigeria and preferred foreign countries were also studied.

Results:

The age of the participants ranged from 26 to 72 (36 standard deviation 8.4) years. There were 159 (85.9%) males. One hundred and twenty-seven, 127/185 (68.6%) study participants had plans to leave the country with the most preferred countries of destination being Canada, United States, United Kingdom and Australia. The most common push factors from Nigeria and pull factors from abroad were similar and included poor income, wages, and salaries in all the participants 185/185 (100%). The most predominant stick factor was family-centric reasons, 126/185 (68.1%). Family and national family remittances were the main benefits, 185/185 (100%) for each while the most common pull factor was higher income, wages, and salaries abroad, 185/185 (100%). The most predominant stick factor was family-centric reasons, 126/185 (68.1%). The greatest benefits were family, 185/185 (100%), and national, 185/185 (100%), financial remittances. The most recommended preventive measures were enhanced income in Nigeria, 185/185 (100%). Young adult age (P< 0.001), male (P< 001), and duration of practice <10 years (P < 0.001) were significantly associated with the plan to leave the country. Conclusion: These findings demonstrates that about 70% of Nigerian medical practitioners plan to leave the country for abroad. The major underlying factors for brain drain include enhanced income in the destination country capacity for financial remittances to the family and nation.
The safety and efficacy of transluminal injection of foam sclerotherapy after endovenous thermal ablation in varicose veins with large trunk: A retrospective cohort study
Authors: Xu Jiatang , Cao Lin , Huang Minyi , Luo Xianghui , Chen Tianhong , Huang Kai , Yao Chen
Published: November 2023

CONTEXT:

Closure rate of endovenous thermal ablation is limited by the trunk diameter of great saphenous vein.

AIMS:

This study aimed to investigate the safety and efficacy of transluminal injection of foam sclerotherapy (TLFS) after thermal ablation in improving the closure rate of primary varicose veins with large trunk.

SUBJECTS AND METHODS:

In this retrospective cohort study with 170 patients (189 legs), the outcomes of varicose veins patients treated with thermal ablation plus injection of sclerotherapy were compared with those treated with thermal ablation only. The primary outcome of this study was the rate of ablated segment closure after surgery and during patient follow-up. Propensity score matching model was used to eliminate the bias.

RESULTS:

After matching, 75 legs (65 patients) from the thermal ablation plus sclerotherapy group and 71 legs (66 patients) from the thermal ablation only group were further analyzed. The closure rate of the thermal ablation plus sclerotherapy group was 97.3%, which was significantly higher than that of the thermal ablation only group (87.3%, P = 0.048), and the closure rate of the thermal ablation plus sclerotherapy group remained higher during 1-year follow-up. No serious complications were observed in groups.

CONCLUSIONS:

TLFS can improve the efficacy of thermal ablation, increasing the closure rate of the ablation segment, and thus improving the symptoms.
Charity Colonoscopy Event and Fund in Singapore: A Novel Method to Raise Awareness of Colorectal Cancer Screening
Authors: Yee Francis Zheng Yi , Ng Yvonne Ying-Ru , Chok Aik Yong , Tan Emile Kwong-Wei , Seow-En Isaac
Published: November 2023

Background:

Despite the improvements in the incidence rate and mortality of colorectal cancer in Singapore, most cases are still diagnosed at later stages. This suggests limitations in the uptake of cancer screening, relating to suboptimal population awareness, unfamiliarity with tests, or cost concerns.

Objective:

We report our experience with a charity colonoscopy event to assist patients with endoscopy costs, raise public awareness of endoscopic cancer screening, and demonstrate the safety of colonoscopy.

Design and Settings:

The Singapore General Hospital (SGH) Preventing Rectal and Colon Cancer through Endoscopy (SPRUCE) fund was established in 2019. A charity endoscopic event was held to kickstart the official launch of the fund with corporate, individual, and industry support.

Patients and Methods:

The recruitment criteria were first-visit patients who required colonoscopic evaluation following specialist evaluation and those in possession of a Community Health Assist Scheme card, for which only Singapore citizens whose annual household per capita income was less than Singapore dollar (SGD) 24,000 (USD 17,500) were eligible. This enabled meaningful selection of patients who would most benefit from financial assistance.

Main Outcome Measures:

To determine the feasibility of a charity colonoscopy event while raising colorectal cancer public awareness.

Sample Size:

Forty-eight patients underwent colonoscopies by accredited endoscopists for the SPRUCE endoscopy event.

Results:

Of the 48 participants, 19 (39.5%) were men and 29 (60.4%) were women, with a median age of 64 years. Seven patients (14.6%) had a normal colonoscopy, while 42 (85.4%) had at least one abnormality documented. Forty-one benign polyps were detected and removed in 22 patients (45.8%), with an overall adenoma detection rate of 85.4%. One patient (2.1%) was diagnosed with colon cancer. No complications resulted from the procedures performed during the charity event.

Conclusion:

A charity colonoscopy event conducted in the form of a health fair for needy patients is feasible and may help raise colorectal cancer awareness. This framework may serve as a useful basis for similar future events held in Singapore or elsewhere.

Limitations:

Lack of longitudinal assessment of colorectal cancer awareness among the public, following the charity colonoscopy event.

Conflict of Interest:

The authors have no conflict of interest to declare.
Anal Pruritus: Diagnosis and Management
Authors: Slagle Daniel T. , Harb William J.
Published: November 2023

Pruritus ani is a condition that results in itching or burning in the perianal area. It can be due to primary or secondary causes and can be self-limiting or persistent. To date, there is limited quality evidence in the literature, and there are no published guidelines to aid the physician in its diagnosis and management. In this article, an overview of the current literature is discussed and a suggested treatment algorithm is provided. A thorough history and physical examination is essential to rule out secondary causes of pruritus. The underlying etiology of pruritus guides management. Education regarding anal hygiene is important for all cases. For any patient with refractory pruritus or an abnormal exam, biopsy should be strongly considered.
Intravascular NK/T-cell lymphoma: a case report and literature review
Authors: Na Ji Min , Jung Wookjae , Kim Minhye , Cheon Yun-Hong , Lee Jong Sil , Song Dae Hyun , Yang Jung Wook
Published: November 2023

Intravascular lymphoma is characterized by an exclusively intravascular distribution of tumor cells. Intravascular natural killer/T-cell lymphoma (IVNKTL) is extremely rare, highly aggressive, commonly Epstein-Barr virus (EBV)–positive, and predominantly affects the skin and central nervous system. Here we report a case of IVNKTL diagnosed in a 67-year-old female, presenting with persistent intermittent fever and skin rashes throughout the body. Incisional biopsy of an erythematous lesion on the chest exhibited aggregation of medium to large-sized atypical lymphoid cells confined to the lumen of small vessels that were positive for CD3, granzyme B, and CD56 on immunohistochemistry and EBV-encoded RNA in situ hybridization. EBV DNA was also detected in serum after diagnosis. With a review of 26 cases of IVNKTL to date, we suggest that active biopsy based on EBV DNA detection may facilitate early diagnosis of IVNKTL.
Implementación de la sentencia Norín Catrimán y otros por la Corte Suprema de Justicia. Análisis de la sentencia AD 1386-2014
Authors: Fuenzalida Bascuñan Sergio Cristian
Published: November 2023

El objetivo de este artículo es revisar la decisión inédita adoptada por nuestra Corte Suprema, en cumplimiento de la sentencia dictada por la Corte Interamericana de Derechos Humanos en el caso Norín Catrimán y otros vs Chile, declarando que los fallos nacionales dictadas por aplicación de la legislación antiterrorista en la primera década del presente siglo, en contra de dirigentes mapuches, han perdido los efectos que les son propios. La Corte respaldó su resolución aduciendo la obligación de cumplir los fallos interamericanos, las facultades conservadoras de los tribunales de justicia y el principio de inexcusabilidad. Esta decisión jurisdiccional es analizada a luz de los propios precedentes de la Corte Interamericana, la posición expresada por la academia en relación al caso, y la doctrina pertinente en materia de derecho internacional y constitucional. Se concluye que la decisión resulta adecuada ponderando los distintos principios jurídicos que estaban en juego.
Etiquetas de sostenibilidad espontáneas y el derecho a una información fidedigna
Authors: Villablanca Lusitania Raquel del Carmen
Published: November 2023

Nuestro principal objetivo es abordar las etiquetas de sostenibilidad espontáneas, ya descritas en otro texto, analizándolas, esta vez, desde el punto de vista del derecho del consumidor a contar con información fidedigna. Interesados en el consumo sostenible hemos empleado como metodología la contrastación entre las funciones que las ciencias económicas reconocen a estas etiquetas, con la regulación relativa al derecho a la información y la publicidad engañosa, a fin de determinar si esta protege debidamente al consumidor consciente frente a las certificaciones que denominamos “artificiales”. Nuestra conclusión afirma que estas certificaciones son efectivamente sancionables en virtud de las normas sobre información y publicidad fidedigna, sin perjuicio de observar que la falta de regulación específica de la industria de la certificación se puede traducir en que se haga responsable al proveedor de artificialidades que son imputables a las certificadoras o inspectoras, “terceros intervinientes” que no están contemplados en las hipótesis previstas en la ley
¿Cambiar injustificadamente? La cuestión de la interrupción civil de la prescripción
Authors: De la Maza Gazmuri Iñigo
Published: November 2023

El propósito de este artículo es doble. De una parte, se trata de mostrar la situación actual de las sentencias relativas a la interrupción civil de la prescripción en la Corte Suprema. Sobre esto, se afirma que hasta una sentencia de 2016 era generalmente pacífico que se producía con la notificación de la demanda; a partir de esa sentencia, las cosas han comenzado a cambiar. De otra parte, se afirma que ni esa sentencia ni las otras que la han seguido ofrecen buenos argumentos para modificar la jurisprudencia existente antes de dicha decisión judicial.
Case Report: Locally Acquired Leptospirosis in a Minnesota Boy and His Dog
Authors: Thielen Beth K. , Holzbauer Stacy , Templen Bethany , Schafer Ilana J. , Artus Aileen , Galloway Renee , Ireland Malia , Femrite Tanya , Schleiss Mark R.
Published: November 2023

Leptospirosis affects numerous animal species, including domestic dogs, but documented transmission to humans is rare. Here, we describe epidemiologically linked cases in a 12-year-old Minnesota boy and his pet dog. While human leptospirosis is often thought of as a disease of tropical locations, this case report describes a rare documented example of local transmission in the northern United States, a region historically not perceived to be at high risk of Leptospira species transmission to humans. This case highlights an unusual presentation, with facial nerve palsy, underappreciated epidemiological risks, and diagnostic challenges of this reemerging infection.
Case Report: The Use of In Vivo Confocal Microscopy for Diagnosis and Monitoring in a Rare Case of Ancaliia algerae Microsporidial Keratitis in New South Wales, Australia
Authors: Sutton Kathryn M. , Watts Matthew R. , Athavale Daniel D. , Lewis Noni , Petsoglou Constantinos , Hudson Bernard J. , Fernando Suran L.
Published: November 2023

We describe the successful management of Ancaliia Algerae microsporidial keratitis in an immunosuppressed 54-year-old woman with refractory linear IgA disease. The case highlights the challenges in diagnosis and management of this infection in immunocompromised individuals and emphasizes the usefulness of in vivo confocal microscopy as a novel, noninvasive tool to aid in the diagnosis and monitoring of microsporidial keratitis. We also discuss the possible mode of acquisition of this rare infection.
THE LATEST IDEAS OF MEDICAL AND BIOLOGICAL DEVELOPMENTS AND IMPROVEMENT OF PSYCHOLOGICAL SCIENCES BY SCIENTISTS
Authors: Vladlenov Denis , Bereziuk Oleg , Vasenko Tetiana , Нrynchak Nataliia , Sprut Olha , Kurdil Nataliia , Бортний Микола , Бірюков В.С. , Ковтун Лариса , Savychuk Oleksandr , Zaitseva Euvheniya , Shapovalova Ganna , Chebotarova Hanna , Stoyanov Oleksandr , Andreeva Tamara , Prokopovych Ihor , Логвіновська Л.М. , Тертична Н.А. , П’янківська Л. , Stasevych Maryna , Сергета Ігор Володимирович , Baieva Olena , Kovalenko Olha , Zelentsova Svitlana , Kryvenko Yevhenii , Svizhak Veronika
Published: November 2023

All rights reserved. Printed in the United States of America. No part of this publication may be reproduced, distributed, or transmitted, in any form or by any means, or stored in a data base or retrieval system, without the prior written permission of the publisher. The content and reliability of the articles are the responsibility of the authors. When using and borrowing materials reference to the publication is required. The collection of scientific articles published is the scientific and practical publication, which contains scientific articles of students, graduate students, Candidates and Doctors of Sciences, research workers and practitioners from Europe and Ukraine. The articles contain the study, reflecting the processes and changes in the structure of modern science.
REVIEW OF THE LATEST OPINIONS AND THEORIES REGARDING THE DEVELOPMENT OF TECHNICAL AND AGRICULTURAL SCIENCES
Authors: Vladlenov Denis , Horbatiuk Kateryna , Babyak Volodymyr , Zaulychna Iryna , Babyak Volodymyr , Василенко Олександр , Намчук Олександра , Мінченков Руслан , Эль Ешеіх Ель Алауі Дуаа , Чвирова Ольга , Синьковська Олена , Bukliv Roksoliana , Komarenska Zoryana , Oliynyk Lilianna , Ciapa Sergiy , Шишацький А. В. , Жук О. В. , Гурський Т. Г. , Маций О. Б. , Шапошнікова О. П. , Kipenskyi Andrii , Shamardina Vira , Korol Yevhen , Babkova Nadiia , Levchuk Rustem , Mylyanych Andriy , Fedorova Olena , Бреус Денис Сергійович , Євтушенко Ольга Тарасівна , Lys Stepan , Yurasova Oksana , Galyanchuk Igor , Redko Yana , Haranina Olga , Vardanian Anna , Переяславцева Олена , Shchukin Oleksandr , Makarov Vitaliy , Kaplin Mykola , Makarova Svitlana , Rymar Тetiana , Чугрій Ганна , Вінюков Олександр , Бондарева Ольга , Вискуб Роман , Юрченко Світлана , Колеснікова Марина , Vyshnevsky Denis , Заєць Анастасія , Shepel Andrii , Aliyev Kamil , Hajiyeva Aytan , Shukur Nasirov , Hajiyeva Aytan , Aliyev Kamil , Karimova Rashida
Published: November 2023

All rights reserved. Printed in the United States of America. No part of this publication may be reproduced, distributed, or transmitted, in any form or by any means, or stored in a data base or retrieval system, without the prior written permission of the publisher. The content and reliability of the articles are the responsibility of the authors. When using and borrowing materials reference to the publication is required. The collection of scientific articles published is the scientific and practical publication, which contains scientific articles of students, graduate students, Candidates and Doctors of Sciences, research workers and practitioners from Europe and Ukraine. The articles contain the study, reflecting the processes and changes in the structure of modern science.
Optimization of Free Vibration for Sandwich Foam Core
Authors: Djamaluddin Fauzan
Published: November 2023

The structural dynamic features of a sandwich foam core structure with core and surface thicknesses are examined to increase the structure's resistance to vibration. The thickness of the core and surface of the sandwich foam core structure are defined as design variables in the optimization function of natural frequency parameters. The finite element analysis program FEA software was used for the analyses. The multi-objective optimization problem using RMS. The derived natural frequencies are compared with the outcomes of the experiments to validate the numerical model. The calculated natural frequencies are compared with the outcomes of the experiments to validate the numerical model. The structural optimization is then completed, using a sandwich foam core structure. The results show that the Aluminium Layer and foam core Thicknesses (m) are 0.0086 and 0,0357 m respectively
La nostalgia de realidad en las aventuras fantásticas de Alicia
Authors: Guajardo-Fajardo Colunga Francisco Javier
Published: November 2023

Las obras de Carroll representan una ajunción en la que coexisten dos visiones radicalmente opuestas de la realidad. En sus obras teóricas, es un lógico perfecto que expone de forma muy clara la belleza y el orden de las ideas. Por el contrario, en Las aventuras de Alice, presenta un mundo sin un orden, una realidad siempre cambiante donde no hay ley a la que aferrarse. Así, en Carroll las dos grandes tradiciones de pensamiento que coexisten en nuestra cultura desde Parménides y Heráclito se funden.
La hipótesis excesiva. El retorno de la religión desde una ontología de la actualidad
Authors: Núñez Moreno José Miguel
Published: November 2023

La filosofía vuelve a interesarse por la religión. Este trabajo pretende establecer un diálogo desapasionado con el pensamiento de Gianni Vattimo en el marco de una aproximación crítica al concepto de "experiencia religiosa" que subyace a su convicción de la religión a la conciencia común y al pensamiento filosófico contemporáneo. Al mismo tiempo, nos gustaría esbozar de la relación entre filosofía y religión, y mostrar la plausibilidad de la mostrar la plausibilidad de esta última en el pensamiento postmodernista, profundizando en las claves de la ontología del tiempo presente que son defendidas por este pensador italiano para este tiempo postsecularizado.
EDUCAÇÃO E CIDADANIA DIGITAL
Authors: Triches Cizelda Aparecida , Triches Jean Carlos , Silva Jordan Luis Artiaga , Silva Luciana Pereira da , Souza Raquel Farias Fuly de
Published: November 2023

Este trabalho trata da relação entre as tecnologias digitais e a cidadania no âmbito da educação. Busca-se responder como as escolas podem usar as tecnologias digitais para formar cidadãos digitais que saibam seus direitos e deveres no mundo online. Para isso, foi desenvolvida uma revisão bibliográfica qualitativa sobre o conceito de cidadania digital, as práticas digitais e os riscos nas escolas, sugerindo-se estratégias pedagógicas para integrar as tecnologias digitais com a cidadania na educação. Constatou-se que as tecnologias digitais têm um papel cada vez mais relevante na educação, pois oferecem novas possibilidades de ensino e aprendizagem, de comunicação e interação, de acesso e produção de informação e conhecimento. No entanto, também trazem novos desafios e riscos, especialmente no contexto das instituições escolares e que dizem respeito à segurança online dos atores educacionais, à privacidade e proteção dos dados, à qualidade e confiabilidade das fontes de informação, à ética e responsabilidade no seu uso, à inclusão e equidade no acesso às oportunidades educacionais, entre outros. Assim, embora não seja possível sobrepor totalmente estes desafios ou eliminar estes riscos, é possível minimizá-los ou preveni-los por meio de algumas estratégias pedagógicas que visam à formação de cidadãos digitais que sejam capazes de usar as tecnologias digitais de forma ética, responsável e efetiva.
OS IMPACTOS DA INSERÇÃO DE TECNOLOGIAS BASEADAS EM INTELIGÊNCIA ARTIFICIAL NA EDUCAÇÃO À DISTÂNCIA
Authors: Marins Josecarlos Emanuel Magalhães , Ferreira Kênia Cristina Soares , Ribeiro Rodrigo Vieira , Galvão Rosângela Cardoso da Silva , Mira Sandra Cristina
Published: November 2023

O avanço da tecnologia tem impulsionado importantes mudanças no mundo contemporâneo, inclusive na área da educação, trazendo grandes ideias para a otimização do ensino e aprendizagem. A Educação à Distância também vem passando por transformações significativas na tentativa de assegurar a qualidade do ensino e aprendizagem aos seus alunos, conectando-se às tecnologias de cada época e adaptando-se às necessidades de cada geração. O presente trabalho abordará as vantagens da inserção da Inteligência Artificial (IA) na Educação à Distância (EaD) e teve como metodologia a pesquisa bibliográfica. O seu objetivo principal é apontar as vantagens advindas da inserção dessas tecnologias para a otimização da Educação à Distância, ajudando o estudante a se tornar cada vez mais autônomo e protagonista de sua aprendizagem. Ao final do estudo, conclui-se que são bastante relevantes os impactos que a Inteligência Artificial causa na aprendizagem, tornando-a uma tendência para o alcance de resultados satisfatórios e condizentes com a época em que vivemos, facilitando na execução do trabalho docente no que se refere à utilização de estratégias de ensino atrativas e diversificadas e ofereça ao estudante a personalização de sua aprendizagem, tornando-o mais autônomo e protagonista na busca de seu sucesso.
AVALIAÇÃO FORMATIVA
Authors: Almeida Agnólia Pereira de , Dias Graciele , Andrade Jaqueline Edy de , Pareschi Sheila Costa Silva , Modesto Valéria Teixeira
Published: November 2023

O processo avaliativo escolar sempre foi algo muito questionado por professores, famílias e estudantes. Muitos desafios na eficácia sobre os resultados obtidos das avaliações somativas são oriundas de que não representam a aprendizagem significativa. Dessa forma a avaliação formativa/processual como referência de aprendizagem, através do uso consciente das plataformas digitais, contribuem significativamente para a autonomia da aprendizagem e consequentemente, o aluno como co-autor na construção do próprio conhecimento. Nota-se que as plataformas digitais contribuem significadamente nesse processo e que o cenário educacional,  não mais pode negar a necessidade da ampliação do uso da avaliação formativa com a utilização das ferramentas  digitais em todas as modalidades de ensino. Porém, o uso das plataformas requer uma postura ética e comprometedora tanto por parte dos profissionais quanto dos alunos com os propósitos colaborativos inerentes para a avaliação se tornar mais eficaz. O objetivo desse trabalho é evidenciar como a avaliação formativa/processual contribui para a formação de estudantes cada vez mais reflexivos e autônomos e colaborativos na busca do conhecimento. A metodologia usada para a obtenção dos resultados foram estudos bibliográficos sobre o tema, trazendo as contribuições das tecnologias digitais como ferramentas colaborativas para o cenário da educação.
TECNOLOGIAS INTEGRADAS À SALA DE AULA
Authors: Nascimento José Leônidas Alves do , Araújo Adriana Persin de , Almeida Agnólia Pereira de , Andrade Clair de , Narciso Rodi
Published: November 2023

Atualmente, apesar de todos os avanços e mudanças tecnológicas, as práticas pedagógicas encontradas em muitas escolas do século XXI ainda permanecem as mesmas ou pouco avançaram. Ademais, as práticas pedagógicas que eram empregadas até o início do século XXI, já não produzem mais os efeitos desejados para os alunos que, nos dias de hoje, frequentam as salas de aula. Logo, essas práticas pedagógicas já não são mais suficientes para que o aluno desenvolva competências e habilidades necessárias para enfrentar os desafios presentes e futuros. Nesse sentido, o estudo teve como objetivo analisar os desafios da educação do século XXI para a integração de tecnologias à sala de aula. Assim, buscou-se identificar os desafios enfrentados pelos professores e instituições para que as tecnologias sejam integradas, de forma efetiva, à sala de aula. Dentre os autores pesquisados para a constituição conceitual deste trabalho, destacaram-se Masetto (2000), Freire (2001), Moran (2007) e Alonso (2014). A metodologia utilizada foi a pesquisa descritiva, tendo como coleta de dados o levantamento bibliográfico. As conclusões mais relevantes indicam a necessidade de capacitação e formação continuada do professor com ênfase no uso das TDICs, a fim de que ele adquira habilidades necessárias para o desempenho da sua função no século XXI, com práticas pedagógicas atuais, auxiliando – de forma mais efetiva – os alunos na busca e construção do conhecimento.
CIDADANIA DIGITAL NA SALA DE AULA
Authors: Alves Luciene , Picão Fábio Fornazieri , Gomes Lucas Ferreira , Barpi Odinei , Luccheti Tatiane Alves
Published: November 2023

Neste trabalho de pesquisa bibliográfica, discutimos a relevância da Tecnologia Baseada em Computador na Sala de Aula, focando em Tecnologias, Cidadania e Educação: Práticas Digitais e Riscos no Contexto das Instituições Escolares. A tecnologia oferece inúmeras vantagens, como o acesso a informações relevantes, aprendizado personalizado e o desenvolvimento de habilidades digitais. No entanto, também enfrenta desafios, como o acesso desigual, distrações e riscos on-line. Um aspecto crucial é a formação de cidadania digital, preparando os alunos para serem responsáveis e éticos no ambiente digital. A tecnologia pode contribuir para o ensino sobre segurança on-line, respeito, ética e discernimento de conteúdo. No entanto, a integração eficaz requer planejamento cuidadoso, formação adequada para os professores e políticas de uso responsável. A inclusão digital e o acesso equitativo às tecnologias são essenciais para evitar desigualdades. Além disso, é importante enfrentar desafios proativamente, garantindo a segurança e o bem-estar dos alunos. A tecnologia pode ajudar a desenvolver habilidades essenciais para o século XXI, mas é fundamental equilibrar seu uso com outras abordagens pedagógicas. Em suma, a Tecnologia Baseada em Computador na Sala de Aula tem o potencial de melhorar a educação, desde que seja utilizada de forma responsável e alinhada aos objetivos educacionais.