bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of modeled 3D solar magnetic field during 30 X/M-class solar flares
Authors: Garland Seth H. , Yurchyshyn Vasyl B. , Loper Robert D. , Akers Benjamin F. , Emmons Daniel J.
Published: May 2024

Using non-linear force free field (NLFFF) extrapolation, 3D magnetic fields were modeled from the 12-min cadence Solar Dynamics Observatory Helioseismic and Magnetic Imager (HMI) photospheric vector magnetograms, spanning a time period of 1 hour before through 1 hour after the start of 18 X-class and 12 M-class solar flares. Several magnetic field parameters were calculated from the modeled fields directly, as well as from the power spectrum of surface maps generated by summing the fields along the vertical axis, for two different regions: areas with photospheric |Bz|≥ 300 G (active region—AR) and areas above the photosphere with the magnitude of the non-potential field (BNP) greater than three standard deviations above |BNP|̄ of the AR field and either the unsigned twist number |Tw| ≥ 1 turn or the shear angle Ψ ≥ 80° (non-potential region—NPR). Superposed epoch (SPE) plots of the magnetic field parameters were analyzed to investigate the evolution of the 3D solar field during the solar flare events and discern consistent trends across all solar flare events in the dataset, as well as across subsets of flare events categorized by their magnetic and sunspot classifications. The relationship between different flare properties and the magnetic field parameters was quantitatively described by the Spearman ranking correlation coefficient, rs. The parameters that showed the most consistent and discernable trends among the flare events, particularly for the hour leading up to the eruption, were the total unsigned flux ϕ), free magnetic energy (EFree), total unsigned magnetic twist (τTot), and total unsigned free magnetic twist (ρTot). Strong (|rs| ∈ [0.6, 0.8)) to very strong (|rs| ∈ [0.8, 1.0]) correlations were found between the magnetic field parameters and the following flare properties: peak X-ray flux, duration, rise time, decay time, impulsiveness, and integrated flux; the strongest correlation coefficient calculated for each flare property was 0.62, 0.85, 0.73, 0.82, −0.81, and 0.82, respectively.
Comparison of vertical jump and sprint performances between 3 × 3 and 5 × 5 elite professional male basketball players
Authors: Cabarkapa Dimitrije , Johnson Quincy R. , Aleksic Jelena , Cabarkapa Damjana V. , Philipp Nicolas M. , Sekulic Marko , Krsman Darko , Trunic Nenad , Fry Andrew C.
Published: May 2024

Given its fast-growing popularity and unique on-court competitive demands, 3 × 3 basketball has captured a considerable amount of attention over recent years. However, unlike research focused on studying 5 × 5 basketball players, there is a lack of scientific literature focused on examining countermovement vertical jump (CMJ) and sprint performance characteristics of 3 × 3 athletes. Thus, the purpose of the present study was to compare force-time metrics during both eccentric and concentric phases of the CMJ and acceleration and deceleration capabilities between 3 × 3 and 5 × 5 top-tier professional male basketball athletes. Ten 3 × 3 and eleven 5 × 5 professional basketball players volunteered to participate in the present study. Upon completion of a standardized warm-up, each athlete performed three maximum-effort CMJs, followed by two 10 m sprints. A uni-axial force plate system sampling at 1,000 Hz was used to analyze CMJ force-time metrics and a radar gun sampling at 47 Hz was used to derive sprint acceleration-deceleration measures. Independent t-tests and Hedge's g were used to examine between-group statistically significant differences (p < 0.05) and effect size magnitudes. The findings of the present study reveal that 3 × 3 and 5 × 5 professional male basketball players tend to display similar neuromuscular performance characteristics as no significant differences were observed in any force-time metric during both eccentric and concentric phases of the CMJ (g = 0.061–0.468). Yet, prominent differences were found in multiple measures of sprint performance, with large effect size magnitudes (g = 1.221–1.881). Specifically, 5 × 5 basketball players displayed greater average and maximal deceleration and faster time-to-stop than their 3 × 3 counterparts. Overall, these findings provide reference values that sports practitioners can use when assessing athletes' CMJ and sprint performance capabilities as well as when developing sport-specific training regimens to mimic on-court competitive demands.
Platelet phosphatidylserine exposure and microparticle production as health bioindicators in marine mammals
Authors: Felipo-Benavent Mar , Valls Mónica , Monteiro Maria Céu , Jávega Beatriz , García-Párraga Daniel , Rubio-Guerri Consuelo , Martínez-Romero Alicia , O’Connor José-Enrique
Published: May 2024

In human medicine, various pathologies, including decompression sickness, thrombocytopenia, and rheumatoid arthritis, have been linked to changes in cellular microparticles (MP) formation, particularly platelet microparticles (PMP). Similar disorders in marine mammals might be attributed to anthropogenic threats or illnesses, potentially impacting blood PMP levels. Thus, detecting platelet phosphatidylserine (PS) exposure and PMP formation could serve as a crucial diagnostic and monitoring approach for these conditions in marine mammals. Our group has developed a methodology to assess real-time PS exposure and PMP formation specifically tailored for marine mammals. This method, pioneered in species such as bottlenose dolphins, beluga whales, walruses, and California sea lions, represents a novel approach with significant implications for both clinical assessment and further research into platelet function in these animals. The adapted methodology for evaluating PS exposure and PMP formation in marine mammals has yielded promising results. By applying this approach, we have observed significant correlations between alterations in PMP levels and specific pathologies or environmental factors. These findings underscore the potential of platelet function assessment as a diagnostic and monitoring tool in marine mammal health. The successful adaptation and application of this methodology in marine mammals highlight its utility for understanding and managing health concerns in these animals.
Microencapsulated essential oils alleviate diarrhea in weaned piglets by modulating the intestinal microbial barrier as well as not inducing antibiotic resistance: a field research
Authors: Xu Xianbin , Mo Kaibin , Cui Can , Lan Yanhua , Ling Lifang , Xu Jinxia , Li Li , Huang Xianhui
Published: May 2024

Microencapsulated essential oils (MEO)have been used as antibiotic alternatives that can be applied to alleviate diarrhea in weaning piglet. We examined a large group of weaned piglets and incorporated essential oil containing thymol (2%), carvacrol (5%) and cinnamaldehyde (3%) in the feed of weaned piglets on an intensive production farm. The piglets were divided into four groups; Control (no additions) and chlortetracycline (Chl), essential oil (EO) and microencapsulated essential oil (MEO) were fed ad libitum over a 28-day trial period. We found MEO significantly reduced the incidence of diarrhea in the piglets that was also accompanied by increased average daily weight gains from days 14–28 (p < 0.05). MEO enhanced the antioxidant capacity in the piglets and serum total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-px) levels were significantly increased (p < 0.05). MEO also significantly reduced expression of genes related to ileal inflammation (IL-6, TNF-α and TGF-β1) (p < 0.05) and significantly (p < 0.05) increased in sIgA antibody levels. MEO influenced the composition of the intestinal microbiome and reduced Bacteroidota (p < 0.05) and thus altered the Firmicutes/Bacteroidota ratio. However, none of the treatments produced significant changes in the most common tetracycline resistance genes (p > 0.05). Metagenomic analysis indicated that MEO impacted DNA expression, virulence factors, antioxidant activity and antimicrobial activity. Metabolomic analysis of the intestinal content also indicated that MEO impacted tyrosine metabolism and primary bile acid biosynthesis suggesting improved intestinal health and nutrient absorption. This study paves the way for further research into the development and optimization of MEO-based interventions aimed at improving piglet health and performance while also providing a reference for reducing reliance on antibiotics in animal agriculture.
Sociedades de Beneficio e Interés Colectivo en Ecuador. Los primeros pasos de un modelo de sostenibilidad empresarial impostergable
Authors: Moscoso-Serrano Ximena , Cevallos-Rodríguez Estefanía , Reyes-Clavijo Marco
Published: May 2024

Los problemas sociales y ambientales que afronta el mundo hoy en día están llegando a niveles alarmantes, por lo que es necesario que todos los actores contribuyan a la solución de estas problemáticas. El papel que pueden jugar las empresas en la mitigación de estos desajustes es un tema relevante. La figura societaria de las BIC (Sociedades de Beneficio e Interés Colectivo) representa un impulso importante para los empresarios comprometidos con la generación del triple impacto: económico, ambiental y social. El presente estudio buscó evaluar el accionar de las sociedades declaradas como BIC en el Ecuador luego de dos años del reconocimiento de esta figura en la Ley, para ello se revisaron los informes de impacto de gestión (IIG) presentados por estas empresas al organismo de control y se realizaron entrevistas a directivos de sociedades de este tipo, para conocer información cualitativa sobre las motivaciones y obstáculos que enfrentan al asumir este modelo de negocios. Los resultados muestran que muchas de las sociedades BIC en el Ecuador no tienen claro el concepto de BIC y no están listas aún para asumir este compromiso y que apenas un promedio del 8% de las empresas declaradas como BIC en 2020 y 2021 cumplieron con la obligación de presentar su informe de impacto de gestión. Esta investigación permite conocer cómo evoluciona en el Ecuador uno de los modelos de sostenibilidad empresarial más representativos en Latinoamérica y proporciona luces sobre lo que se necesita hacer para impulsarlo.
Segmentation and Tracking Based on Equalized Memory Matching Network and Its Application in Electric Substation Inspection
Authors: Zhang Huanlong , Zhou Bin , Tian Yangyang , Li Zhe
Published: May 2024

With the wide application of deep learning, power inspection technology has made great progress. However, substation inspection videos often present challenges such as complex backgrounds, uneven lighting distribution, variations in the appearance of power equipment targets, and occlusions, which increase the difficulty of object segmentation and tracking, thereby adversely affecting the accuracy and reliability of power equipment condition monitoring. In this paper, a pixel-level equalized memory matching network (PEMMN) for power intelligent inspection segmentation and tracking is proposed. Firstly, an equalized memory matching network is designed to collect historical information about the target using a memory bank, in which a pixel-level equalized matching method is used to ensure that the reference frame information can be transferred to the current frame reliably, guiding the segmentation tracker to focus on the most informative region in the current frame. Then, to prevent memory explosion and the accumulation of segmentation template errors, a mask quality evaluation module is introduced to obtain the confidence level of the current segmentation result so as to selectively store the frames with high segmentation quality to ensure the reliability of the memory update. Finally, the synthetic feature map generated by the PEMMN and the mask quality assessment strategy are unified into the segmentation tracking framework to achieve accurate segmentation and robust tracking. Experimental results show that the method performs excellently on real substation inspection scenarios and three generalized datasets and has high practical value.
Validating Synthetic Data for Perception in Autonomous Airport Navigation Tasks
Authors: de Frutos Carro Miguel Ángel , Villalonga Carlos Cerdán , Cruz Antonio Barrientos
Published: May 2024

Autonomous navigation within airport environments presents significant challenges, mostly due to the scarcity of accessible and labeled data for training autonomous systems. This study introduces an innovative approach to assess the performance of vision-based models trained on synthetic datasets, with the goal of determining whether simulated data can train and validate navigation operations in complex airport environments. The methodology includes a comparative analysis employing image processing techniques and object detection algorithms. A comparative analysis of two different datasets was conducted: a synthetic dataset that mirrors real airport scenarios, generated using the Microsoft Flight Simulator 2020®video game, and a real-world dataset. The results indicate that models trained on a combination of both real and synthetic images perform much better in terms of adaptability and accuracy compared to those trained only on one type of dataset. This analysis makes a significant contribution to the field of autonomous airport navigation and offers a cost-effective and practical solution to overcome the challenges of dataset acquisition and algorithm validation. It is thus believed that this study lays the groundwork for future advancements in the field.
The Effect of Furrow Opener and Disc Coulter Configurations on Seeding Performance under Different Residue Cover Densities
Authors: Karayel Davut , Jotautienė Eglė , Šarauskis Egidijus
Published: May 2024

The performance of the no-till seeder is one of the most important factors that affect the success of the no-tillage. Striking the right balance between furrow opener design and residue cover is essential for optimizing seeding conditions and ensuring sustainable agricultural practices that promote both soil conservation and high-yield crop production. This study investigates the impact of residue cover on no-tillage maize seeding after wheat harvest, focusing on plant spacing, seeding depth, mean emergence time, and percent emergence. Trials with hoe-type and double-disc-type furrow openers, accompanied by plain- or ripple-disc-type coulters, were conducted in Antalya, Turkey. The results indicate that residue cover had no significant effect on mean plant spacing, but a higher residue cover increased spacing variation. The seeding depth in hoe-type furrow opener trials remained consistent, while double-disc-type furrow openers showed lower depths with 80% and 90% residue covers. The percentage of plant emergence and mean emergence time decreased as the residue cover increased in double-disc-type furrow opener trials. At 90% residue cover, PE decreased to 60%. The impact of disc coulters on hoe-type furrow openers was limited, but they increased seeding depth and MET in double-disc-type furrow openers. These findings can help optimize residue management for improved efficiency in no-till farming systems.
Remote Sensing Crop Water Stress Determination Using CNN-ViT Architecture
Authors: Lehouel Kawtar , Saber Chaima , Bouziani Mourad , Yaagoubi Reda
Published: May 2024

Efficiently determining crop water stress is vital for optimising irrigation practices and enhancing agricultural productivity. In this realm, the synergy of deep learning with remote sensing technologies offers a significant opportunity. This study introduces an innovative end-to-end deep learning pipeline for within-field crop water determination. This involves the following: (1) creating an annotated dataset for crop water stress using Landsat 8 imagery, (2) deploying a standalone vision transformer model ViT, and (3) the implementation of a proposed CNN-ViT model. This approach allows for a comparative analysis between the two architectures, ViT and CNN-ViT, in accurately determining crop water stress. The results of our study demonstrate the effectiveness of the CNN-ViT framework compared to the standalone vision transformer model. The CNN-ViT approach exhibits superior performance, highlighting its enhanced accuracy and generalisation capabilities. The findings underscore the significance of an integrated deep learning pipeline combined with remote sensing data in the determination of crop water stress, providing a reliable and scalable tool for real-time monitoring and resource management contributing to sustainable agricultural practices.
Comparative Study of Systemic vs. Local Antibiotics with Subgingival Instrumentation in Stage III–IV Periodontitis: A Retrospective Analysis
Authors: Ilyes Ioana , Boariu Marius , Rusu Darian , Iorio-Siciliano Vincenzo , Vela Octavia , Boia Simina , Radulescu Viorelia , Șurlin Petra , Jentsch Holger , Lodin Alexandru , Stratul Stefan-Ioan
Published: May 2024

To improve the clinical and microbiological outcomes of non-surgical mechanical periodontal therapy, the adjunctive use of antimicrobials has been utilized in treating moderate-to-severe periodontitis. In our study, the retrospective design included previously collected health-related patient data, obtained from the printed and digital charts of patients who received systemic or local antibiotic adjuncts to SI (subgingival instrumentation). A total of 34 patients (diagnosed with generalized Stage III/IV periodontitis) met the inclusion and exclusion criteria and were evaluated. The samples were tested for the following bacterial strains: Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis (P. gingivalis), Prevotella intermedia (P. intermedia), Tanererella forsythia (T. forsythia), and Treponema denticola (T. denticola). The inter-group comparisons of the bacterial species did not show statistically significant differences between groups. The present study aimed to evaluate the clinical effects after SI and the adjunctive use of systemically administered (SA) AMX (amoxicillin) + MET (metronidazole) (administered for 7 days), with locally delivered (LDD) piperacillin + tazobactam in step 2 of periodontal therapy. Results: Overall, all parameters were improved in the groups, with a significant difference in inter-group comparison regarding the full-mouth bleeding score (FMBS) (p < 0.05) in favor of the SA group, and the p-value < 0.05 was considered to be statistically significant. Statistically significant PPD (probing pocket depth) reductions and CAL (clinical attachment level) gains were observed in both groups at the 3-month follow-up. In conclusion, within the limitations, the outcomes of this study suggest that SI, with adjunctive local or systemic antibiotic therapy, provided comparable clinical improvements. Systemic AMX + MET protocols were more efficacious with regard to the reduction in FMBS. Follow-up studies with larger patient numbers are needed to further investigate this effect.
Tiny Organs, Big Impact: How Microfluidic Organ-on-Chip Technology Is Revolutionizing Mucosal Tissues and Vasculature
Authors: Dasgupta Ishita , Rangineni Durga , Abdelsaid Hasan , Ma Yixiao , Bhushan Abhinav
Published: May 2024

Organ-on-chip (OOC) technology has gained importance for biomedical studies and drug development. This technology involves microfluidic devices that mimic the structure and function of specific human organs or tissues. OOCs are a promising alternative to traditional cell-based models and animals, as they provide a more representative experimental model of human physiology. By creating a microenvironment that closely resembles in vivo conditions, OOC platforms enable the study of intricate interactions between different cells as well as a better understanding of the underlying mechanisms pertaining to diseases. OOCs can be integrated with other technologies, such as sensors and imaging systems to monitor real-time responses and gather extensive data on tissue behavior. Despite these advances, OOCs for many organs are in their initial stages of development, with several challenges yet to be overcome. These include improving the complexity and maturity of these cellular models, enhancing their reproducibility, standardization, and scaling them up for high-throughput uses. Nonetheless, OOCs hold great promise in advancing biomedical research, drug discovery, and personalized medicine, benefiting human health and well-being. Here, we review several recent OOCs that attempt to overcome some of these challenges. These OOCs with unique applications can be engineered to model organ systems such as the stomach, cornea, blood vessels, and mouth, allowing for analyses and investigations under more realistic conditions. With this, these models can lead to the discovery of potential therapeutic interventions. In this review, we express the significance of the relationship between mucosal tissues and vasculature in organ-on-chip (OOC) systems. This interconnection mirrors the intricate physiological interactions observed in the human body, making it crucial for achieving accurate and meaningful representations of biological processes within OOC models. Vasculature delivers essential nutrients and oxygen to mucosal tissues, ensuring their proper function and survival. This exchange is critical for maintaining the health and integrity of mucosal barriers. This review will discuss the OOCs used to represent the mucosal architecture and vasculature, and it can encourage us to think of ways in which the integration of both can better mimic the complexities of biological systems and gain deeper insights into various physiological and pathological processes. This will help to facilitate the development of more accurate predictive models, which are invaluable for advancing our understanding of disease mechanisms and developing novel therapeutic interventions.
Edible Paper Sheets from Alternanthera philoxeroides and Hypophthalmichthys molitrix: Smart Biomass Valorization
Authors: Suraiya Sharmin , Mohona Mst. , Fatema Mst , Haq Monjurul , Rahman Md. , Mondal Subrata
Published: May 2024

Alternanthera philoxeroides and Hypophthalmichthys molitrix offer significant nutritional benefits. This study evaluates the proximate composition, amino acid profile, GC-MS analysis, FT-IR spectroscopy, SEM and EDX, and color values of edible paper sheets (EPSs) derived from Alternanthera philoxeroides incorporating different levels of Hypophthalmichthys molitrix flesh. The protein content in the EPSs varied based on fish flesh incorporation, peaking at 52.66% in Ap100/Hm300 (Non-boil). Protein and carbohydrate contents showed an inverse correlation across EPSs, with the highest carbohydrate content of 60.89% in sample Ap400/Hm0 (Boil). Lipid content was also found to correlate with H. molitrix flesh content in EPSs, ranging from 1.59% to 18.41%. Amino acid analysis identified 11 types, with methionine as the most prevalent, followed by leucine, phenylalanine, and lysine. GC-MS analysis revealed 51 bioactive compounds, including carbonic acid, hentriacontane, and various fatty acids. FT-IR analysis showed characteristic bonds, while color analysis displayed L* values ranging from 24.37 to 30.97. SEM analyses depicted the microstructure, surface view, and elemental composition of the EPSs, and EDX showed an abundance of Ca, N, K, O, C, Mg, Na, P, Cl, Mn, and Fe. Therefore, EPSs prepared from A. philoxeroides and H. molitrix could offer a promising approach for effectively utilizing aquatic biomass and providing both plant and animal nutrients to consumers.
Cerebral Amyloidosis in Individuals with Subjective Cognitive Decline: From Genetic Predisposition to Actual Cerebrospinal Fluid Measurements
Authors: Sampatakakis Stefanos N. , Mourtzi Niki , Charisis Sokratis , Kalligerou Faidra , Mamalaki Eirini , Ntanasi Eva , Hatzimanolis Alex , Koutsis Georgios , Ramirez Alfredo , Lambert Jean-Charles , Yannakoulia Mary , Kosmidis Mary H. , Dardiotis Efthimios , Hadjigeorgiou Georgios , Sakka Paraskevi , Rouskas Konstantinos , Patas Kostas , Scarmeas Nikolaos
Published: May 2024

The possible relationship between Subjective Cognitive Decline (SCD) and dementia needs further investigation. In the present study, we explored the association between specific biomarkers of Alzheimer’s Disease (AD), amyloid-beta 42 (Aβ42) and Tau with the odds of SCD using data from two ongoing studies. In total, 849 cognitively normal (CN) individuals were included in our analyses. Among the participants, 107 had available results regarding cerebrospinal fluid (CSF) Aβ42 and Tau, while 742 had available genetic data to construct polygenic risk scores (PRSs) reflecting their genetic predisposition for CSF Aβ42 and plasma total Tau levels. The associations between AD biomarkers and SCD were tested using logistic regression models adjusted for possible confounders such as age, sex, education, depression, and baseline cognitive test scores. Abnormal values of CSF Aβ42 were related to 2.5-fold higher odds of SCD, while higher polygenic loading for Aβ42 was associated with 1.6-fold higher odds of SCD. CSF Tau, as well as polygenic loading for total Tau, were not associated with SCD. Thus, only cerebral amyloidosis appears to be related to SCD status, either in the form of polygenic risk or actual CSF measurements. The temporal sequence of amyloidosis being followed by tauopathy may partially explain our findings.
Alterations in Skeletal Muscle Insulin Signaling DNA Methylation: A Pilot Randomized Controlled Trial of Olanzapine in Healthy Volunteers
Authors: Burghardt Kyle J. , Burghardt Paul R. , Howlett Bradley H. , Dass Sabrina E. , Zahn Brent , Imam Ahmad A. , Mallisho Abdullah , Msallaty Zaher , Seyoum Berhane , Yi Zhengping
Published: May 2024

Antipsychotics are associated with severe metabolic side effects including insulin resistance; however, the mechanisms underlying this side effect are not fully understood. The skeletal muscle plays a critical role in insulin-stimulated glucose uptake, and changes in skeletal muscle DNA methylation by antipsychotics may play a role in the development of insulin resistance. A double-blind, placebo-controlled trial of olanzapine was performed in healthy volunteers. Twelve healthy volunteers were randomized to receive 10 mg/day of olanzapine for 7 days. Participants underwent skeletal muscle biopsies to analyze DNA methylation changes using a candidate gene approach for the insulin signaling pathway. Ninety-seven methylation sites were statistically significant (false discovery rate < 0.05 and beta difference between the groups of ≥10%). Fifty-five sites had increased methylation in the skeletal muscle of olanzapine-treated participants while 42 were decreased. The largest methylation change occurred at a site in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha (PPARGC1A) gene, which had 52% lower methylation in the olanzapine group. Antipsychotic treatment in healthy volunteers causes significant changes in skeletal muscle DNA methylation in the insulin signaling pathway. Future work will need to expand on these findings with expression analyses.
Combination of a Synthetic Bioceramic Associated with a Polydioxanone-Based Membrane as an Alternative to Autogenous Bone Grafting
Authors: Frigério Paula Buzo , de Moura Juliana , Pitol-Palin Letícia , Monteiro Naara Gabriela , Mourão Carlos Fernando , Shibli Jamil Awad , Okamoto Roberta
Published: May 2024

The purpose of this study was to evaluate the repair process in rat calvaria filled with synthetic biphasic bioceramics (Plenum® Osshp-70:30, HA:βTCP) or autogenous bone, covered with a polydioxanone membrane (PDO). A total of 48 rats were divided into two groups (n = 24): particulate autogenous bone + Plenum® Guide (AUTOPT+PG) or Plenum® Osshp + Plenum® Guide (PO+PG). A defect was created in the calvaria, filled with the grafts, and covered with a PDO membrane, and euthanasia took place at 7, 30, and 60 days. Micro-CT showed no statistical difference between the groups, but there was an increase in bone volume (56.26%), the number of trabeculae (2.76 mm), and intersection surface (26.76 mm2) and a decrease in total porosity (43.79%) in the PO+PG group, as well as higher values for the daily mineral apposition rate (7.16 µm/day). Histometric analysis presented material replacement and increased bone formation at 30 days compared to 7 days in both groups. Immunostaining showed a similar pattern between the groups, with an increase in proteins related to bone remodeling and formation. In conclusion, Plenum® Osshp + Plenum® Guide showed similar and sometimes superior results when compared to autogenous bone, making it a competent option as a bone substitute.
Clinical Characteristics and Treatment of Juvenile Myasthenia Gravis—A Single-Center Experience
Authors: Maeda Mikiko , Shimomura Hideki , Tokunaga Sachi , Taniguchi Naoko , Lee Tomoko , Takeshima Yasuhiro
Published: May 2024

Juvenile myasthenia gravis (MG) is a rare autoimmune neuromuscular disease, often treated with anticholinesterases, corticosteroids, and immunosuppressants. However, optimal treatment durations remain unclear. This study investigated the clinical characteristics and treatment of juvenile MG, including medication duration. The administration period for all drugs, immunosuppressants, and prednisolone at doses greater than 0.35 mg/kg daily was extracted retrospectively from medical records. Nineteen participants (8 boys, 11 girls) aged 8 months to 14 years (median, 2.5 years) at onset were identified. Fourteen patients (73.7%) had ocular MG and five (26.3%) had generalized MG. Drug treatment was conducted in 18 cases; however, 7 patients did not complete the treatment. Among the patients who completed drug treatment, the duration of treatment ranged from 11 to 100 months (median, 47 months). In the six patients treated with continuous administration of prednisolone or immunosuppressants, the treatment duration ranged from 33 to 99 months (median, 56 months). No severe adverse effects requiring hospitalization were reported. The patients treated with prednisolone or immunosuppressants required at least 33 months of treatment. These results will help develop protocols for juvenile MG treatment.
The Impact of Aerobic Dance Intervention on Postural Balance in Children: A Randomized Controlled Trial
Authors: Jouira Ghada , Alexe Cristina Ioana , Zinelabidine Khawla , Rebai Haithem , Mocanu George Danuț , Cojocaru Adin Marian , Dragomir Luciana , Čaušević Denis , Sahli Sonia
Published: May 2024

This study aimed to investigate the impact of an 8-week aerobic dance intervention on postural balance in children. Forty-one children, aged 9 to 11, were randomly assigned to either an aerobic dance group (ADG) or a control group (CG) from a primary school. Postural balance was assessed using center of pressure (CoP) excursions before and after the 8-week intervention period. Evaluations were conducted on both firm and foam surfaces in bipedal and unipedal stances under open-eyes (OE) and closed-eyes (CE) conditions, as well as on both medial–lateral (ML) and anterior–posterior (AP) surfaces in a bipedal stance under OE conditions. The ADG exhibited significantly decreased CoPVm values during firm bipedal CE, unipedal OE, foam bipedal OE and CE, and foam unipedal OE (p < 0.005). This study suggests that aerobic dance intervention improved postural balance in children, showcasing adaptability and improved stability under various conditions.
The Role of Parental Health Literacy in Establishing Health-Promoting Habits in Early Childhood
Authors: Csima Melinda , Podráczky Judit , Keresztes Viktória , Soós Evelin , Fináncz Judit
Published: May 2024

In early childhood, children are extremely susceptible to the acquisition of habits and the establishment of health-promoting habits. Therefore, the patterns, routines, and rules transmitted and expected by the adults surrounding the child are of paramount importance and can correlate with the level of their health literacy. Our cross-sectional, quantitative, exploratory study aimed to examine the relationships between parental health literacy and preschool children’s health-related habits, using simple, non-random sampling (n = 598). In addition to the sociodemographic characteristics, the measuring tool we compiled included the standardized European Health Literacy Survey Questionnaire (HLS-EU-Q16), as well as a set of questions containing 30 statements suitable for exploring children’s habit systems. The health literacy of the parents involved in our study proved to be more favorable than that of the general population. Regarding children’s habit systems, we found significant differences in several areas by age group (p < 0.05) and gender (p < 0.05). The levels of parental health literacy (0.003 ≤ p ≤ 0.048) and parents’ education (p < 0.05) show a correlation with the children’s health-related habit systems: the indicators of children with parents who have a higher level of health literacy and a higher level of education are more favorable in terms of established habits. In the long term, the formation of health-promoting habits may facilitate the internalization of favorable health behavior motives for the future, contributing to the establishment of positive physical, mental, and social health in adulthood.
Strength and Durability Properties of High-Volume Fly Ash (HVFA) Binders: A Systematic Review
Authors: Runganga Desire , Okonta Felix , Musonda Innocent
Published: May 2024

South Africa is endowed with a wealth of coal-fired power stations that can produce extremely high volumes of fly ash per year exceeding 34 million tonnes. The use of high-volume fly ash (HVFA) binders in the construction sector has the capacity to significantly reduce greenhouse gas emissions associated with traditional cement production and offset the carbon footprint of Eskom. The excessive production of fly ash by Eskom warrants the need for developing ultra-high-volume fly ash binders (UHVFA, fly ash/binder > 60 wt%). Nonetheless, fly ash (FA) replacement of cement is still largely limited to 35% regardless of more ambitious research indicating the potential to surpass 60%. In view of the urgent need for South Africa to offset and reduce its carbon footprint, this work reviews and summarises the literature on the performance of HVFA binders with a focus on two specific areas: (i) strength and (ii) durability. On HVFA binder strength, the focus is drawn on work that analysed the compressive strength, flexural strength, and split tensile strength. This review focuses on the extant literature analysing the durability of HVFA binders using various tests, including sorptivity, resistivity, permeability, tortuosity, rapid chloride penetration tests, resistance to sulphate attack, and microstructural analysis. As the FA content increases towards optima, i.e., 50–80%, the most indicative composite characteristics of the strength and durability properties are UCS (30–90 MPa) and permeability (low). This review reveals the leading methodologies, instrumentation, findings, challenges, and contradictions.
Chlorate and Trichloromethane Residues in Bulk Tank Milk Produced in the Republic of Ireland before and after Chlorine was Prohibited as a Cleaning Agent on Farms
Authors: Twomey Lorna , Furey Ambrose , O’Brien Bernadette , Beresford Tom , Reid Paula , Danaher Martin , Gleeson David
Published: May 2024

In an effort to reduce the occurrence of chlorine derived residues such as chlorate and trichloromethane (TCM) in milk and ultimately in dairy products, ‘chlorine-free’ cleaning of milking equipment became compulsory in the Republic of Ireland (ROI) from January 2021. While data exists on TCM levels in bulk tank milk, little is known about the prominence and typical levels (mg/kg) of chlorate residue in bulk tank milk. To address this, 3625 bulk milk samples were collected from six milk processors and were analysed for chlorate and TCM residues across 2020 and 2021, with 2020 representing a period before chlorine-free cleaning was introduced and 2021 being the period after chlorine removal. In 2020, 15% of the samples analysed had detectable levels of chlorate (0.0020–1.6 mg/kg), but this reduced to 8% in 2021 (0.0020–3.9 mg/kg), following the introduction of ‘chlorine-free’ cleaning. Chlorate and TCM residues have not been totally eliminated because sources of residue other than cleaning chemicals exist, i.e., chlorinated water.
Does Quantum Mechanics Require “Conspiracy”?
Authors: Stoica Ovidiu Cristinel
Published: May 2024

Quantum states containing records of incompatible outcomes of quantum measurements are valid states in the tensor-product Hilbert space. Since they contain false records, they conflict with the Born rule and with our observations. I show that excluding them requires a fine-tuning to an extremely restricted subspace of the Hilbert space that seems “conspiratorial”, in the sense that (1) it seems to depend on future events that involve records (including measurement settings) and on the dynamical law (normally thought to be independent of the initial conditions), and (2) it violates Statistical Independence, even when it is valid in the context of Bell’s theorem. To solve the puzzle, I build a model in which, by changing the dynamical law, the same initial conditions can lead to different histories in which the validity of records is relative to the new dynamical law. This relative validity of the records may restore causality, but the initial conditions still must depend, at least partially, on the dynamical law. While violations of Statistical Independence are often seen as non-scientific, they turn out to be needed to ensure the validity of records and our own memories and, by this, of science itself. A Past Hypothesis is needed to ensure the existence of records and turns out to require violations of Statistical Independence. It is not excluded that its explanation, still unknown, ensures such violations in the way needed by local interpretations of quantum mechanics. I suggest that an as-yet unknown law or superselection rule may restrict the full tensor-product Hilbert space to the very special subspace required by the validity of records and the Past Hypothesis.
Time-Domain Self-Clustering-Based Diagnosis Applied on Open Cathode Fuel Cell
Authors: Dijoux Etienne , Damour Cédric , Alicalapa Frédéric , Aubier Alexandre , Benne Michel
Published: May 2024

The ability of a diagnosis tool to observe an abnormal state of a system remains a major issue for health monitoring. For that purpose, several diagnosis tools have been proposed in the literature. Most of them are developed for specific system characterization, and the genericity of the approaches is not considered. Indeed, most approaches proposed in the literature are based on an expert offline consideration that makes it hard to apply the strategy to other systems. It is therefore important to develop a diagnostic tool that takes as little as possible expert knowledge to reduce the dependency between the tool and the system. This paper, therefore, focuses on the application of a generic diagnosis tool on an open cathode fuel cell. The goal is to feed the diagnosis algorithm with a voltage measurement and let it proceed to a self-clustering of the signal components. Each cluster’s interpretation remains to be established by the expert point of view that is then involved downstream of the diagnosis tool.
CMSS: A High-Performance Blockchain Storage System with Horizontal Scaling Support
Authors: Yang Wenjin , Ao Meng , Gao Mingzhi , Li Chunhai , Chen Yongqing
Published: May 2024

As a decentralized system, blockchain has been widely used in numerous areas and has become a hot topic in both industry and academia. The increasing demand for blockchain causes heavy storage consumption which seriously affects the performance of blockchain, especially in the context of massive volumes of data. To solve these problems, many related systems like sharding and sidechain have been proposed to improve the efficiency and scalability of blockchain. However, in practical deployment scenarios, these systems still have problems, such as low read–write performance, and reorganization and synchronization of ledger data after storage expansion, which cause the storage system’s expansion to become difficult and time-consuming in large-scale blockchain systems. Facing these problems, in this paper we propose ChainMaker Storage System (CMSS). CMSS is a blockchain storage system with high read-and-write performance and horizontal scaling support. It has been used as the storage system of the most popular permissioned blockchain ChainMaker. There are three contributions of our proposed CMSS: (i) a new block storage workflow to achieve high read–write performance; (ii) the Meta File System (MFS) to support the horizontal expansion of blockchain storage; and (iii) hot–cold separation to reduce the resource usage and economic costs. To evaluate the performance of CMSS, we compare CMSS with Hyperledger Fabric (HLF), the most popular permissioned blockchain platform. We select five well-known cloud service providers to calculate the storage cost in a real production environment. The results show that CMSS has better performance in read and write than HLF and advantages in storage capacity and price.
Analyzing Strawberry Preferences: Best–Worst Scaling Methodology and Purchase Styles
Authors: Sparacino Antonina , Ollani Selene , Baima Lorenzo , Oliviero Michael , Borra Danielle , Rui Mingze , Mastromonaco Giulia
Published: May 2024

This research has investigated Italian consumers’ preferences for and purchasing behaviors of strawberries utilizing the Best–Worst Scaling methodology (BWS). This approach enables the key factors that influence strawberry purchasing decisions to be identified and different choice groups to be characterized. To achieve this goal, a survey was conducted on a sample of 496 respondents living in the metropolitan area of Milan (North Italy). The declared preferences of the individuals for 12 strawberry characteristics, divided into intrinsic, extrinsic, and credence attributes, were first measured. A Latent Class Analysis (LCA) was then performed to identify different clusters of consumers according to the individuals’ preferences. Subsequently, the heterogeneity of the clusters was tested, using the Chi-square test, and sociodemographic characteristics and purchasing habits were considered. The results suggest that the most important attribute in the choice of strawberries was appearance, highlighting the importance of preserving it throughout the supply chain, followed by one of the increasingly important aspects of diets, which is health benefits. The attribute considered the least important was the brand. This study demonstrates, from a holistic point of view, that sociodemographic characteristics, food habits, and perceptions of different strawberry attributes influence consumers’ preferences and behaviors. Practical implications suggest a new prospective for communication marketing strategies for producers, creating a better brand identity and highlighting in their marketing all of the aspects that consumers would like to know about the fruits they choose as quality certifications.
Effects of Stocking Density and Pre-Slaughter Handling on the Fillet Quality of Largemouth Bass (Micropterus salmoides): Implications for Fish Welfare
Authors: Hematyar Nima , Rahimnejad Samad , Gorakh Waghmare Swapnil , Malinovskyi Oleksandr , Policar Tomas
Published: May 2024

There is currently insufficient acknowledgment of the relationship between fish welfare and ultimate fillet quality. The purpose of this study was to assess the impacts of pre-slaughter handling and stocking density as fish welfare markers on fillet quality of largemouth bass (Micropterus salmoides). Fish from three stocking densities of 35, 50, and 65 kg·m−3 were reared in a recirculating aquaculture system (RAS) for 12 weeks and received commercial feed. Ultimately, the fish were either stunned with percussion on the head (control group) or subjected to air exposure for 3 min (anoxia group) before stunning and subsequent collection of blood and fillet samples. Western blot analysis revealed the degradation of actin in both groups. Additionally, higher oxidation progress and lower hardness and pH were observed in anoxia compared to the control group. We observed higher hardness at 35 kg·m−3 in anoxia compared to 50 and 65 km−3. The initial hardness values at 35, 50, and 65 km−3 were 1073, 841, and 813 (g) respectively in the anoxia group. Furthermore, the anoxia and control groups had rigor mortis after 6 and 10 h, respectively. Cortisol and glucose levels, and oxidative enzymes activity were higher in anoxia than in the control group. In conclusion, oxidation induced by anoxia likely plays a crucial role as a promoter of the quality deterioration of largemouth bass fillets.
Non-Covalent Cross-Linking Hydrogel: A New Method for Visceral Hemostasis
Authors: Zhao Chenyu , Wang Han , Sun Xue , Liu Ying , Chen Jingjing , Li Jiaqi , Qiu Fanshan , Han Qianqian
Published: May 2024

Excessive blood loss could lead to pathological conditions such as tissue necrosis, organ failure, and death. The limitations of recently developed hemostatic approaches, such as their low mechanical strength, inadequate wet tissue adhesion, and weak hemostatic activity, pose challenges for their application in controlling visceral bleeding. In this study, a novel hydrogel (CT) made of collagen and tannic acid (TA) was proposed. By altering the proportions between the two materials, the mechanical properties, adhesion, and coagulation ability were evaluated. Compared to commercial hydrogels, this hydrogel has shown reduced blood loss and shorter hemostatic time in rat hepatic and cardiac bleeding models. This was explained by the hydrogel’s natural hemostatic properties and the significant benefits of wound closure in a moist environment. Better biodegradability was achieved through the non-covalent connection between tannic acid and collagen, allowing for hemostasis without hindering subsequent tissue repair. Therefore, this hydrogel is a new method for visceral hemostasis that offers significant advantages in treating acute wounds and controlling major bleeding. And the production method is simple and efficient, which facilitates its translation to clinical applications.
Surface Water Resources Planning in an Ungauged Transboundary Basin Using Satellite Products and the AHP Method
Authors: Gharehtikan Seyed Kamal Ghoreishi , Gharechelou Saeid , Mahjoobi Emad , Golian Saeed , Rafiei Fatemeh , Salehi Hossein
Published: May 2024

Global concern over optimizing transboundary water resources for residents is hindered by the lack of observational data, particularly in ungauged basins, mainly due to inaccessibility or security issues. Remote sensing and GIS technology provide a practical solution for monitoring and managing water resources in such basins. This research evaluates surface water resources in the Qaretikan ungauged transboundary basin using satellite products for precipitation, temperature, and evapotranspiration from 2005 to 2014. The accuracy of these datasets was assessed using statistical measures. The water balance components, i.e., precipitation and evaporation, were utilized to calculate runoff over the basin using the Justin method. Downstream environmental flow was estimated using the Lyon method, and available water was determined. This study identified a potential annual storage water of 11.8 MCM in the Qaretikan basin. The Analytic Hierarchy Process (AHP) integrated expert opinions to prioritize water usage decisions based on proposed decision options. The results revealed greenhouse cultivation water allocation as the top priority among the identified options, highlighting its importance in sustainable water resource management within the basin.