bluuebunny/crossref_metadata_2025 huggingface dataset:
Fused Thiophene Semiconductors: Crystal Structure–Film Microstructure Transistor Performance Correlations
Authors: Youn Jangdae , Kewalramani Sumit , Emery Jonathan D. , Shi Yanrong , Zhang Shiming , Chang Hsiu‐Chieh , Liang You‐jhih , Yeh Chia‐Ming , Feng Chieh‐Yuan , Huang Hui , Stern Charlotte , Chen Liang‐Hsiang , Ho Jia‐Chong , Chen Ming‐Chou , Bedzyk Michael J. , Facchetti Antonio , Marks Tobin J.
Published: March 2013

The molecular packing motifs within crystalline domains should be a key determinant of charge transport in thin‐film transistors (TFTs) based on small organic molecules. Despite this implied importance, detailed information about molecular organization in polycrystalline thin films is not available for the vast majority of molecular organic semiconductors. Considering the potential of fused thiophenes as environmentally stable, high‐performance semiconductors, it is therefore of interest to investigate their thin film microstructures in relation to the single crystal molecular packing and OTFT performance. Here, the molecular packing motifs of several new benzo[d,d′]thieno[3,2‐b;4,5‐b′]dithiophene (BTDT) derivatives are studied both in bulk 3D crystals and as thin films by single crystal diffraction and grazing incidence wide angle X‐ray scattering (GIWAXS), respectively. The results show that the BTDT derivative thin films can have significantly different molecular packing from their bulk crystals. For phenylbenzo[d,d′]thieno[3,2‐b;4,5‐b′]dithiophene (P‐BTDT), 2‐biphenylbenzo[d,d′]thieno‐[3,2‐b;4,5‐b′]dithiophene (Bp‐BTDT), 2‐naphthalenylbenzo[d,d′]thieno[3,2‐b;4,5‐b′]dithiophene (Np‐BTDT), and bisbenzo[d,d′]thieno[3,2‐b;4,5‐b′]dithiophene (BBTDT), two lattices co‐exist, and are significantly strained versus their single crystal forms. For P‐BTDT, the dominance of the more strained lattice relative to the bulk‐like lattice likely explains the high carrier mobility. In contrast, poor crystallinity and surface coverage at the dielectric/substrate interface explains the marginal OTFT performance of seemingly similar PF‐BTDT films.
Dimeric Gold Nanoparticle Assemblies as Tags for SERS‐Based Cancer Detection
Authors: Indrasekara A. Swarnapali D. S. , Paladini Bryan J. , Naczynski Dominik J. , Starovoytov Valentin , Moghe Prabhas V. , Fabris Laura
Published: March 2013

Herein, a new class of multifunctional materials combining a clustered nanoparticle‐based probe is presented for surface enhanced Raman scattering (SERS)‐based microscopy and surface functionalization for tissue targeting. Controlled assembly of spherical gold nanoparticles into dimers (DNP‐REP) is engineered using a small, rigid Raman‐active dithiolated linking reporter (REP) to yield narrow internanoparticle gaps and to strategically generate the “hot spot” while concurrently placing the reporter within the region of highest SERS enhancement. Peptide functionalized DNP‐REP materials are highly stable even upon incubation with living cells and show controlled levels of binding and intracellular endocytosis. To demonstrate the functionality of such probes for disease detection, differentially targeted DNP‐REPs are incubated over various time points with cultured human glioblastoma cells. Using human glioblastoma cells, the SERS maps of targeted tumor cells show the markedly enhanced signals of the DNP‐REP, compared to conventional confocal fluorescence based approaches, especially at low incubation times. Even with as few as 40 internalized DNP‐REP, a relatively intense SERS signal is measured, demonstrating the high signal to noise ratio and inherent biocompatibility of the materials. Thus, these Raman reporter‐based nanoparticle cluster probes present a promising and versatile optical imaging tool for fast, reliable, selective, and ultrasensitive tissue targeting and disease detection and screening.
Apparent Germline Mosaicism for a Novel 19p13.13 Deletion Disrupting NFIX and CACNA1A
Authors: Nimmakayalu Manjunath , Horton V. Kim , Darbro Ben , Patil Shivanand R. , Alsayouf Hamza , Keppler‐Noreuil Kim , Shchelochkov Oleg A.
Published: March 2013

We report on a case of apparent germline mosaicism in a family of two sisters carrying a novel 19p13.13 deletion. The 11‐year‐old proposita was referred for evaluation of macrocephaly, moderate intellectual disability (ID), and episodic ataxia. Array comparative genomic hybridization (CGH) detected a 399 kb microdeletion with breakpoints within genes NFIX and CACNA1A. A similar deletion was also seen in the elder sibling who presented with macrocephaly, ID, and strabismus. The deletions were confirmed to be de novo after the parental aCGH analysis suggesting that this is an example of germinal mosaicism. This study contributes additional information for the newly identified 19p13 deletion syndrome and clarifies the clinical roles of genes in the involved region. This case of apparent germline mosaicism represents the only known family in the cohort of 1,800 patients analyzed by our group. © 2013 Wiley Periodicals, Inc.
Epidemiology of hereditary sensory and autonomic neuropathy type IV and V in Japan
Authors: Haga Nobuhiko , Kubota Masaya , Miwa Zenzo
Published: March 2013

Hereditary sensory and autonomic neuropathy (HASN) refers to a group of rare congenital disorders characterized by loss of pain sensation and other sensory or autonomic abnormalities. Among them, a relatively large proportion of patients with HSAN type IV, which is accompanied by anhidrosis and intellectual disability, are reported from Israel and Japan. HSAN type V, with normal sweating and mental development, is rarely reported in Japan. In 2009, we founded a research group for congenital insensitivity to pain and performed the first epidemiological survey of HSAN types IV and V in Japan. Questionnaires were sent to a total of 3,488 certified training institutions of five nationwide medical societies comprising pediatricians, neurologists, orthopedic surgeons, and dentists. Answers were obtained from 1,610 institutions, and 192 HSAN patients (152 with type IV and 28 with type V) were reported from 105 institutions. After excluding duplicated patients, we identified a total of 62 current, 36 past, and five deceased patients for HSAN‐IV, and a total of 14 current, 13 past, and 0 deceased patients for HSAN‐V. Using these figures, we estimated that the number of Japanese patients with HSAN types IV and V as 130–210 and 30–60 patients, respectively. We identified no gender differences, and patients with a family history of the disorder were limited to affected siblings in both conditions. Most patients with HSAN‐IV were 5–40 years of age, whereas half of the patients with HSAN‐V were 40 years or older. © 2013 Wiley Periodicals, Inc.
On photo‐electron angular distributions from clusters
Authors: Wopperer Philipp , Reinhard Paul‐Gerhard , Suraud Eric
Published: March 2013

The distributions of electrons emitted from a metal cluster after laser excitation are analyzed from a theoretical perspective. The focus is laid on the angular distributions of the emitted electrons taking, in particular, the anisotropy as measure for the basic shape. This observable is discussed at various levels of sophistication, from stationary perturbation theory to a fully dynamical simulation of the electron dynamics using time‐dependent density‐functional theory. The simple most approach, perturbation theory with outgoing plane waves, can be treated mostly analytically which provides useful, qualitative insights into the mechanisms determining the angular distributions. Comparing the model, an extreme sensitivity of the results to all details of the cluster has been found. This requires a theoretical description without compromises. Using a fully dynamical simulation with detailed ionic background yields generally smooth trends for the frequency dependence of the anisotropy, with emission preferably along the laser polarization plus some isotropic background. Weakly bound cluster ions make an exception for frequencies near emission threshold where a generic tendency to sidewards emission prevails.
Relationship of Bone Mineral Density to Progression of Knee Osteoarthritis
Authors: Lee Ji Y. , Harvey William F. , Price Lori L. , Paulus Jessica K. , Dawson‐Hughes Bess , McAlindon Timothy E.
Published: March 2013

Objective

To evaluate the longitudinal relationship between bone mineral density (BMD) and BMD changes and the progression of knee osteoarthritis (OA), as measured by cartilage outcomes.

Methods

We used observational cohort data from the Vitamin D for Knee Osteoarthritis trial. Bilateral femoral neck BMD values as well as knee magnetic resonance imaging (MRI) scans in each subject were obtained at baseline and subsequently at 12 months and 24 months. The change in total cartilage volume and tibial and femoral cartilage thickness was measured by manual cartilage segmentation of 2 sequential knee MRI scans in each subject. Multivariable linear regression models were used to examine the associations of baseline BMD and BMD change with the cartilage outcomes, adjusting for baseline age, sex, body mass index, malalignment, and vitamin D treatment. Model fit and assumptions were validated.

Results

A total of 127 subjects were eligible for analysis. Longitudinal BMD loss was associated with loss of cartilage volume (β = 1.25 per 0.1 gm/cm2, P = 0.02) and loss of tibial cartilage thickness (β = 0.028, P = 0.03). BMD loss of a magnitude greater than the least significant change (<−4.7%) was associated with 1.02% cartilage volume loss per year (P = 0.005), 0.014 mm femoral cartilage thickness loss (P = 0.04), and 0.021 mm tibial cartilage thickness loss per year (P = 0.009). There were no significant associations between baseline BMD and any of the cartilage outcomes.

Conclusion

Longitudinal BMD loss is associated with progressive cartilage loss in knees with OA. Further work to clarify the basis of this relationship could reveal novel therapeutic targets for knee OA.
Tumor Necrosis Factor Receptor Type I Expression of CD4+ T Cells in Rheumatoid Arthritis Enables Them to Follow Tumor Necrosis Factor Gradients Into the Rheumatoid Synovium
Authors: Rossol Manuela , Schubert Kristin , Meusch Undine , Schulz Anett , Biedermann Bernd , Grosche Jens , Pierer Matthias , Scholz Roger , Baerwald Christoph , Thiel Andreas , Hagen Sebastian , Wagner Ulf
Published: March 2013

Objective

The cytokine tumor necrosis factor (TNF) plays a central role in the pathogenesis of rheumatoid arthritis (RA), but its disease‐specific effector mechanisms have not been fully elucidated. This study was undertaken to investigate the role of TNF in T cell accumulation and migration in the synovitic joints of RA patients.

Methods

Vital tissue sections from rheumatoid synovium were generated using a horizontally oscillating microtome and were coincubated with fluorescence‐labeled CD4+ T cells. Migration was detected by fluorescence and confocal microscopy. Migrating T cells were recovered from the tissue and analyzed for phenotype. Chemotaxis of CD4+ T cells from RA patients in response to increasing concentrations of TNF was analyzed in Transwell experiments.

Results

CD4+ T cells from RA patients migrated into the tissue sections in significantly higher numbers than T cells from healthy controls. Migrating CD4+ T cells differed from nonmigrating ones in their increased expression of TNF receptor type I (TNFRI), which was expressed on a fraction of circulating CD4+ T cells from RA patients, but not from controls. CD4+ T cells from the peripheral blood of RA patients were also found to migrate along TNF concentration gradients ex vivo. Accordingly, blockade of either TNF or TNFRI nearly abrogated in vitro T cell migration in synovial tissue.

Conclusion

Our findings indicate that the interaction of TNF with TNFRI is pivotal for T cell migration in synovial tissue in vitro, and thereby suggest a relevant role of the cytokine for in vivo T cell trafficking to synovitic joints.
Seed storage proteins as a system for teaching protein identification by mass spectrometry in biochemistry laboratory
Authors: Wilson Karl A. , Tan‐Wilson Anna
Published: March 2013

Mass spectrometry (MS) has become an important tool in studying biological systems. One application is the identification of proteins and peptides by the matching of peptide and peptide fragment masses to the sequences of proteins in protein sequence databases. Often prior protein separation of complex protein mixtures by 2D‐PAGE is needed, requiring more time and expertise than instructors of large laboratory classes can devote. We have developed an experimental module for our Biochemistry Laboratory course that engages students in MS‐based protein identification following protein separation by one‐dimensional SDS‐PAGE, a technique that is usually taught in this type of course. The module is based on soybean seed storage proteins, a relatively simple mixture of proteins present in high levels in the seed, allowing the identification of the main protein bands by MS/MS and in some cases, even by peptide mass fingerprinting. Students can identify their protein bands using software available on the Internet, and are challenged to deduce post‐translational modifications that have occurred upon germination. A collection of mass spectral data and tutorials that can be used as a stand‐alone computer‐based laboratory module were also assembled. © 2013 by The International Union of Biochemistry and Molecular Biology 41(2):79‐86, 2013.
Pharmacokinetic application of a bio‐analytical LC‐MS method developed for 5‐fluorouracil and methotrexate in mouse plasma, brain and urine
Authors: Ganti Vaishnavi , Walker Ellen A. , Nagar Swati
Published: March 2013

In the past we have reported significant cognitive deficits in mice receiving 5‐fluorouracil in combination with low‐dose methotrexate. To explain such interactions, a pharmacokinetic study was designed. A sensitive bio‐analytical method was therefore developed and validated for 5‐fluorouracil and methotrexate in mouse plasma, brain and urine with liquid chromatography coupled to a single quadrupole mass spectrometer. Chromatographic separation was accomplished by Agilent® Zorbax® SB‐C18 column, with isocratic elution (5 mM ammonium acetate and methanol, 70:30, %v/v) at a flow rate of 300 μL/min. The limit of quantitation for both drugs was 15.6 ng/mL (plasma and brain) and 78.1 ng/mL (urine), with interday and intraday precision and accuracy ≤15% and a total run time of 6 min. This bio‐analytical method was used for the pharmacokinetic characterization of 5‐fluorouracil and methotrexate in mouse plasma, brain and urine over a period of 24 h. This method allowed characterization of the brain concentrations of 5‐fluorouracil over a period of 24 h. Copyright © 2013 John Wiley & Sons, Ltd.
Variability in the Essential‐Oil Composition of Sideritis scardicaGriseb. from Native Bulgarian Populations
Authors: Trendafilova Antoaneta B. , Todorova Milka N. , Evstatieva Ljuba N. , Antonova Daniela V.
Published: March 2013

The essential‐oil composition of six native populations of Sideritis scardica from Bulgaria was studied by GC‐FID and GC/MS analyses. Altogether, 37 components, representing 73.1 to 79.2% of the total oil content were identified. Among them, α‐pinene (4.4–25.1%), β‐pinene (2.8–18.0%), oct‐1‐en‐3‐ol (2.3–8.0%), phenylacetaldehyde (0.5–9.5%), β‐bisabolene (1.3–11.0%), benzyl benzoate (1.1–14.3%), and m‐camphorene (1; 0.3–12.4%) were the main compounds. All samples were characterized by low contents of oxygenated mono‐ and sesquiterpenes (≤1.6 and 2.3%, resp.). Principal component analysis (PCA) and cluster analysis (CA) showed a significant variability in the chemical composition of the studied samples as well as a correlation between the oil profiles and the ecological conditions of the natural habitats of S. scardica.
Antioxidative and Melanogenesis‐Inhibitory Activities of Caffeoylquinic Acids and Other Compounds from Moxa
Authors: Akihisa Toshihiro , Kawashima Kohta , Orido Masashi , Akazawa Hiroyuki , Matsumoto Masahiro , Yamamoto Ayako , Ogihara Eri , Fukatsu Makoto , Tokuda Harukuni , Fuji Jizaemon
Published: March 2013

The MeOH extract of moxa, the processed leaves of Artemisia princeps Pamp. (Asteraceae), exhibited potent 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical‐scavenging activity and melanogenesis‐inhibitory activity in α‐melanocyte‐stimulating hormone (α‐MSH)‐stimulated B16 melanoma cells. Eight caffeoylquinic acids, 1 and 6–12, five flavonoids, 13–17, two benzoic acid derivatives, 18 and 19, three coumarin derivatives, 20–22, four steroids, 23–26, and six triterpenoids, 27–32, were isolated from the MeOH extract. Upon evaluation of compounds 1, 6–23, and four semisynthetic caffeoylquinic acid esters, 2–5, for their DPPH radical‐scavenging activity, 15 compounds, 1–13, 17, and 19, showed potent activities (IC50 3.1–16.8 μM). The 15 compounds exhibited, moreover, potent inhibitory activities (51.1–92.5% inhibition) against peroxidation of linoleic acid emulsion at 10 μg/ml concentration. In addition, when 27 compounds, 1–8, 10, 12, 13, 15–18, 20–25, and 27–32, were evaluated for their inhibitory activity against melanogenesis in α‐MSH‐stimulated B16 melanoma cells, five caffeoylquinic acids, i.e., chlorogenic acid (1), ethyl chlorogenate (3), propyl chlorogenate (4), isopropyl chlorogenate (5), and butyl chlorogenate (6), along with homoorientin (17) and vanillic acid (18), exhibited inhibitory activities with 33–62% reduction of melanin content at 100 μM concentration with no or almost no toxicity to the cells (89–114% of cell viability at 100 μM). Western blot analysis showed that compound 6 reduced the protein levels of microphtalmia‐associated transcription factor (MITF), tyrosinase, tyrosine‐related protein 1 (TRP‐1), and TRP‐2 mostly in a concentration‐dependent manner, suggesting that this compound inhibits melanogenesis on α‐MSH‐stimulated B16 melanoma cells by, at least in part, inhibiting the expression of MITF, followed by decreasing the expression of tyrosinase, TRP‐1, and TRP‐2. Furthermore, four compounds, 13, 15, 16, and 30, exhibited cytotoxicities against HL60 human leukemia cell line (IC50 7.0–11.1 μM), and nine compounds, 14–16, 23, 26–28, 31, and 32, showed inhibitory effects (IC50 272–382 mol ratio/32 pmol 12‐O‐tetradecanoylphohrbol‐13‐acetate (TPA)) against EpsteinBarr virus early antigen (EBV‐EA) activation induced by TPA in Raji cells.
A Peptide Nucleic Acid (PNA) Heteroduplex Probe Containing an Inosine–Cytosine Base Pair Discriminates a Single‐Nucleotide Difference in RNA
Authors: Matsumoto Katsuhiko , Nakata Eiji , Tamura Tomoki , Saito Isao , Aizawa Yasunori , Morii Takashi
Published: March 2013

Selective discrimination of a single‐nucleotide difference in single‐stranded DNA or RNA remains a challenge with conventional DNA or RNA probes. A peptide nucleic acid (PNA)‐derived probe, in which PNA forms a pseudocomplementary heteroduplex with inosine‐containing DNA or RNA, effectively discriminates a single‐nucleotide difference in a closely related group of sequences of single‐stranded DNA and/or RNA. The pseudocomplementary PNA heteroduplex is easily converted to a fluorescent probe that distinctively detects a member of highly homologous let‐7 microRNAs.
ChemInform Abstract: Bismuth Flux Growth of CeRh6Ge4 and CeRh2Ge2 Single Crystals.
Authors: Vosswinkel Daniel , Niehaus Oliver , Rodewald Ute Ch. , Poettgen Rainer
Published: March 2013

Single crystals of the title compounds are grown from the elements in a bismuth flux (evacuated silica tube, 1320 K, 1 h).
ChemInform Abstract: New Facile Method for the Preparation of M3B7O13I Boracites (M: Mn, Fe, Co, Ni, Cd).
Authors: Wang Xiu‐Li , Huang Yi‐Zhi , Wu Li‐Ming
Published: March 2013

The title compounds are prepared from the corresponding transition metal oxides, B2O3, elemental boron, and I2 by a two‐crucible method (350—750 °C, 3 d, 70—95% yield).
ChemInform Abstract: Hydrophobic Core—Hydrophilic Shell‐Structured Catalysts: A General Strategy for Improving the Reaction Rate in Water.
Authors: Yang Hengquan , Jiao Xuan , Li Shuru
Published: March 2013

A novel heterogeneous palladium catalyst featuring a structure of hydrophobic core — hydrophilic shell is prepared and successfully applied for the hydrogenation of different substrates in aqueous media.
ChemInform Abstract: A Polycomponent Metal‐Catalyzed Aliphatic, Allylic, and Benzylic Fluorination.
Authors: Bloom Steven , Pitts Cody Ross , Miller David Curtin , Haselton Nathan , Holl Maxwell Gargiulo , Urheim Ellen , Lectka Thomas
Published: March 2013

The selective incorporation of fluorine into organic molecules is achieved using Selectfluor in combination with a three‐component catalytic system.
ChemInform Abstract: Pd‐PEPPSI‐IPentCl: A Highly Effective Catalyst for the Selective Cross‐Coupling of Secondary Organozinc Reagents.
Authors: Pompeo Matthew , Froese Robert D. J. , Hadei Niloufar , Organ Michael G.
Published: March 2013

Among various catalysts tested, PES is found to be the most efficient one to couple allylzinc bromides and aryl halides with high selectivity for the branched product (III) in favor of the linear one.
ChemInform Abstract: Silver‐Catalyzed Decarboxylative Alkynylation of Aliphatic Carboxylic Acids in Aqueous Solution.
Authors: Liu Xuesong , Wang Zhentao , Cheng Xiaomin , Li Chaozhong
Published: March 2013

The reactions proceed via an SET/radical pathway.
ChemInform Abstract: Nickel‐Catalyzed Intermolecular [2 + 2] Cycloaddition of Conjugated Enynes with Alkenes.
Authors: Nishimura Akira , Ohashi Masato , Ogoshi Sensuke
Published: March 2013

The chemo‐ and regioselective cycloaddition of conjugated enynes with electron‐deficient as well as electronically neutral alkenes provides highly substituted cyclobutene derivatives.
ChemInform Abstract: Selective Access to Both Diastereoisomers in an Enantioselective Intramolecular Michael Reaction by Using a Single Chiral Organocatalyst and Application in the Formal Total Synthesis of (‐)‐Epibatidine.
Authors: Jensen Kim L. , Weise Christian F. , Dickmeiss Gustav , Morana Fabio , Davis Rebecca L. , Joergensen Karl Anker
Published: March 2013

From organocatalytic intramolecular Michael addition reaction of nitro‐enones both diastereomers can be selectively obtained depending on the reaction conditions.
ChemInform Abstract: Enzyme‐Mediated Enantioselective Hydrolysis of Dicarboxylic Acid Monoesters.
Authors: Kataoka Noriyuki , Okudomi Masayuki , Chihara Naoka , Matsumoto Kazutsugu
Published: March 2013

The separation of the reaction products is accomplished by a simple extraction procedure.
ChemInform Abstract: α‐Triethylsilyl‐α‐diazoacetone in Double Cross‐Aldolisation: Convenient Acetone Equivalent Toward 5‐Hydroxy‐1,3‐diketones.
Authors: Gosselin Pascal , et al. et al.
Published: March 2013

An original and convergent approach to the versatile 5‐hydroxy‐1,3‐diketone scaffold (VI) is described using α‐silyl‐α‐diazoketone (I) as synthetic equivalent of acetone.
ChemInform Abstract: Catalytic Aerobic Production of Imines en route to Mild, Green, and Concise Derivatizations of Amines.
Authors: Sonobe Toshiaki , Oisaki Kounosuke , Kanai Motomu
Published: March 2013

The present new oxidation method is applicable to a wide range of primary and secondary amines whereas, no reaction is observed for tertiary amines.
ChemInform Abstract: Ultrasound‐Promoted Sterically Congested Passerini Reactions under Solvent‐Free Conditions.
Authors: Cui Can , Zhu Cong , Du Xiu‐Jiang , Wang Zhi‐Peng , Li Zheng‐Ming , Zhao Wei‐Guang
Published: March 2013

High‐power ultrasound is efficiently applied for the acceleration of solvent‐free Passerini reaction leading to α‐acyloxy amides (IV), (VIII) and (X).
ChemInform Abstract: Iron‐Facilitated Oxidative Dehydrogenative C—O Bond Formation by Propargylic Csp3—H Functionalization.
Authors: Wang Teng , Zhou Wang , Yin Hang , Ma Jun‐An , Jiao Ning
Published: March 2013

Treatment of 1‐aryl‐3‐chloro‐1‐propynes with NaN3 generates intermediates whose azido function acts as an assisting group in C—H activation and facilitates the reaction with carboxylic acids.
ChemInform Abstract: An Unexpected Rearrangement—Hydration Reaction Sequence of 2H‐Chromenes to Dihydrochalcones under Catalysis of HAuCl4.
Authors: Maiti Gourhari , Kayal Utpal , Karmakar Rajiv , Bhattacharya Rudraksha N.
Published: March 2013

A simple protocol is developed for the conversion of various substrates into highly functionalized propanone frameworks.
ChemInform Abstract: Catalytic Asymmetric Construction of Spiro(γ‐butyrolactam‐γ‐butyrolactone) Moieties Through Sequential Reactions of Cyclic Imino Esters with Morita—Baylis—Hillman Bromides.
Authors: Teng Huai‐Long , Huang He , Wang Chun‐Jiang
Published: March 2013

The first catalytic asymmetric preparation of the highly functionalized title compounds, valuable building blocks for drug discovery, is presented.
ChemInform Abstract: Trimethyl‐4‐oxo‐4,5,6,7‐tetrahydroindazole‐1‐acetic Acid: A New Lead Compound with Selective COX‐2 Inhibitory Activity.
Authors: Abdel‐Rahman Hamdy M. , Ozadali Keriman
Published: March 2013

The condensation of dimedone derivative (I) with ethyl hydrazinoacetate proceeds regioselectively.
ChemInform Abstract: Carbodiimides in the Synthesis of Enamino‐ and α‐Aminophosphonates as Peptidomimetics of Analgesic/Antiinflammatory and Anticancer Agents.
Authors: Abdou Wafaa M. , Barghash Reham F. , Bekheit Mohamed S.
Published: March 2013

The reactions of the highly unstable carbodiimide (III) with different phosphonates are studied and the activities of the products are evaluated.
ChemInform Abstract: Synthesis of Oxazoles Through Copper‐Mediated Aerobic Oxidative Dehydrogenative Annulation and Oxygenation of Aldehydes and Amines.
Authors: Xu Zejun , Zhang Chun , Jiao Ning
Published: March 2013

The procedure can be applied to various benzylic aldehydes and aliphatic or benzylic amines.
ChemInform Abstract: Biomimetic Oxidative Coupling of Benzylamines and 2‐Aminophenols: Synthesis of Benzoxazoles.
Authors: Endo Yoshinori , Baeckvall Jan‐E.
Published: March 2013

The reaction proceeds under aerobic conditions to afford a wide range of benzoxazoles.
ChemInform Abstract: Desulfurization Strategy in the Construction of Azoles Possessing Additional Nitrogen, Oxygen or Sulfur Using a Copper(I) Catalyst.
Authors: Guin Srimanta , Rout Saroj Kumar , Gogoi Anupal , Nandi Shyamapada , Ghara Krishna Kanta , Patel Bhisma K.
Published: March 2013

This one‐pot tandem synthesis can be used to synthesize 5‐aminotetrazoles (III), 3‐amino[1,2,4]triazoles (VII), 2‐amino[1,3,4]oxadiazoles (X), and 2,5‐diamino[1,3,4]thiadiazoles (XII).
ChemInform Abstract: Design and Synthesis of Polycyclic Imidazole‐Containing N‐Heterocycles Based on C—H Activation/Cyclization Reactions.
Authors: Iaroshenko Viktor O. , Ostrovskyi Dmytro , Miliutina Mariia , Maalik Aneela , Villinger Alexander , Tolmachev Andrei , Volochnyuk Dmitriy M. , Langer Peter
Published: March 2013

A wide range of imidazole‐containing N‐heterocycles is prepared via intramolecular C—H/C—Hal and C—H/C—H coupling reactions.
ChemInform Abstract: Nafion‐H®‐Catalyzed Synthesis of Polyhydroquinolines via the Hantzsch Multicomponent Reaction.
Authors: Kidwai Mazaahir , Chauhan Ritika , Bhatnagar Divya , Singh Abhay K. , Mishra Biswajit , Dey Sharmistha
Published: March 2013

The catalyst can be reused for four runs without loss of catalytic activity.
ChemInform Abstract: Synthesis, Antitumor and Antimicrobial Testing of Some New Thiopyrimidine Analogues.
Authors: Taher Azza Taher , Helwa Amira Atef
Published: March 2013

New compounds (Ib) and (IVd) show high inhibitory activities against leukemia.
ChemInform Abstract: Copper‐Catalyzed Three‐Component One‐Pot Synthesis of Quinazolines.
Authors: Ju Jia , Hua Ruimao , Su Ji
Published: March 2013

Two efficient approaches to multi‐substituted quinazolines are presented both using aqueous ammonia as nitrogen source.
ChemInform Abstract: Synthesis and Biological Evaluation of Selective and Potent Cyclin‐Dependent Kinase Inhibitors.
Authors: N'gompaza‐Diarra Joannah , Bettayeb Karima , Gresh Nohad , Meijer Laurent , Oumata Nassima
Published: March 2013

A substitution reaction between purine derivative (I) and chiral aminodiols leads to novel 2‐substituted purines such as (III), which are structurally related to the cyclin‐dependent kinase (CDK) inhibitor roscovitine.
ChemInform Abstract: Sequential Three‐Component Synthesis of 1,4‐Bis[triazolo[4,5‐d]pyrimidin‐7(6H)‐one]piperazines (IV)
Authors: Fang Zheng Dong , Wei Xian Hong
Published: March 2013

15 examples
ChemInform Abstract: Synthesis, Antimicrobial and Cytotoxicity Study of 1,3‐Disubstituted‐1H‐naphtho[1,2‐e][1,3]oxazines.
Authors: Verma Vikas , Singh Kuldeep , Kumar Devinder , Klapoetke Thomas M. , Stierstorfer Joerg , Narasimhan Balasubramanian , Qazi Asif Khurshid , Hamid Abid , Jaglan Sundeep
Published: March 2013

A series of novel symmetrically (II) as well as unsymmetrically (VI) diaryl‐substituted 1H‐naphtho[1,2‐e][1,3]oxazines are synthesized and screened for their antimicrobial and cytotoxic activities.
ChemInform Abstract: Access to Sultams by Rhodium(III)‐Catalyzed Directed C—H Activation.
Authors: Pham Manh V. , Ye Baihua , Cramer Nicolai
Published: March 2013

Acylated aromatic sulfonamides undergo cyclization reaction with symmetrical or unsymmetrical internal alkynes to yield aryl sultams.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Hydrogenation of N‐Hydroxy‐α‐imino Phosphonates Using Broensted Acid as Activator. The First Catalytic Enantioselective Approach to Chiral N‐Hydroxy‐α‐amino Phosphonates.
Authors: Goulioukina Nataliya S. , Shergold Ilya A. , Bondarenko Grigorii N. , Ilyin Mikhail M. , Davankov Vadim A. , Beletskaya Irina P.
Published: March 2013

This is the first catalytic, most straightforward, and atom‐economical approach to enantioenriched N‐hydroxy‐α‐amino‐phosphonates (II).
ChemInform Abstract: 3‐P=O‐Functionalized Phospholane 1‐Oxides by the Michael Reaction of 1‐Phenyl‐2‐phospholene 1‐Oxide and Dialkyl Phosphites, H‐Phosphinates, or Diphenylphosphine Oxide.
Authors: Jablonkai Erzsebet , Drahos Laszlo , Drzazga Zbigniew , Pietrusiewicz K. Michal , Keglevich Gyoergy
Published: March 2013

The reaction proceeds better under conventional conditions.
ChemInform Abstract: 4‐Organochalcogenoyl‐1H‐1,2,3‐triazoles: Synthesis and Functionalization by a Nickel‐Catalyzed Negishi Cross‐Coupling Reaction.
Authors: Stefani Helio A. , Leal Daiana M. , Manarin Flavia
Published: March 2013

The click chemistry concept gives rise to formation of organoselenium‐ and organotelluriumtriazoles (III) and (V) in moderate to good yields via 1,3‐dipolar cycloaddition employing organochalcogen acetylenes (I) and (IV).
ChemInform Abstract: Molten Carbonates in the Energy Field, as Electrolytes, Composite Materials, Fuel Carriers or Reaction Media
Authors: Cassir M.
Published: March 2013

Review: 31 refs.
ChemInform Abstract: Recent Progress in Cathode Materials Research for Advanced Lithium Ion Batteries
Authors: Xu Bo , Qian Danna , Wang Ziying , Meng Ying Shirley
Published: March 2013

Review: 159 refs.
ChemInform Abstract: Action of Bimetallic Nanocatalysts under Reaction Conditions and During Catalysis: Evolution of Chemistry from High Vacuum Conditions to Reaction Conditions
Authors: Tao Franklin , Zhang Shiran , Nguyen Luan , Zhang Xueqiang
Published: March 2013

Review: 100 refs.
ChemInform Abstract: Bimetallic Catalysts for Hydrogen Generation
Authors: Wei Zhehao , Sun Junming , Li Yan , Datye Abhaya K. , Wang Yong
Published: March 2013

Review: 88 refs.
ChemInform Abstract: Syntheses and Applications of Monofluorinated Cyclopropanes
Authors: David Emilie , Milanole Gaelle , Ivashkin Pavel , Couve‐Bonnaire Samuel , Jubault Philippe , Pannecoucke Xavier
Published: March 2013

Review: 74 refs.
ChemInform Abstract: Super‐Electrophilic 10π Heteroaromatics. New Mechanistic and Synthetic Applications
Authors: Kurbatov Sergey , Lakhdar Sami , Goumont Regis , Terrier Francois
Published: March 2013

Review: 233 refs.
ChemInform Abstract: Metallasilsesquioxanes: Molecular Analogues of Heterogeneous Catalysts
Authors: Ward Antony J. , Masters Anthony F. , Maschmeyer Thomas
Published: March 2013

Review: 55 refs.
ChemInform Abstract: Organomanganese‐Mediated Radical Reactions
Authors: Friestad Gregory K.
Published: March 2013

Review: 141 refs.
ChemInform Abstract: Organocatalytic Tandem Michael Addition Reactions: A Powerful Access to the Enantioselective Synthesis of Functionalized Chromenes, Thiochromenes and 1,2‐Dihydroquinolines
Authors: Bhanja Chittaranjan , Jena Satyaban , Nayak Sabita , Mohapatra Seetaram
Published: March 2013

Review: 77 refs.
ChemInform Abstract: Stereocontrolled Domino Reactions
Authors: Pellissier Helene
Published: March 2013

Review: 373 refs.
ChemInform Abstract: Syntheses and Applications of Functionalized Bicyclo[3.2.1]octanes: Thirteen Years of Progress
Authors: Presset Marc , Coquerel Yoann , Rodriguez Jean
Published: March 2013

Review: 373 refs.
ChemInform Abstract: Exploration of Versatile Geminal Bis(silane) Chemistry
Authors: Gao Lu , Zhang Yuebao , Song Zhenlei
Published: March 2013

Review: 57 refs.
ChemInform Abstract: Chemical Constituents of Bryophytes — Bio‐ and Chemical Diversity, Biological Activity, and Chemosystematics
Authors: Asakawa Y. , Ludwiczuk A. , Nagashima F.
Published: March 2013

Review: 990 refs.
3,4‐Dinitrobenzamide Functionalized CdTe/ZnTe Quantum Dots as a Nanoprobe for Imaging Glutathione S‐Transferase in Living Cells
Authors: Lu Jinxin , Song Yanchao , Shi Wen , Li Xiaohua , Ma Huimin
Published: March 2013

A novel fluorescent nanoprobe for glutathione S‐transferase (GST) has been developed by incorporating 3,4‐dinitrobenzamide (a specific substrate of GST) onto CdTe/ZnTe quantum dots. The probe itself displays a low background signal due to the strong quenching effect of the electron‐withdrawing unit of 3,4‐dinitrobenzamide on the quantum dots. However, GST can efficiently catalyze the nucleophilic substitution of reduced glutathione on the p‐nitro group of the nanoprobe, leading to a large fluorescence enhancement. Most notably, this enhancement shows high selectivity and sensitivity towards GST instead of the other biological substances. With this nanoprobe, a simple fluorescence imaging method for intracellular GST has been established, and its applicability has been successfully demonstrated for imaging GST in different living cells, which reveals that A549 cells express GST about 3 times higher than NIH‐3T3 and Hela cells.
Chromatic adaptation by illuminant matrix products: An alternative to sharpened von kries primaries
Authors: Brill Michael H. , Oleari Claudio
Published: March 2013

Previous attempts to predict chromatic‐adaptation correspondence have led to a sharpening dilemma—i.e., Von Kries primaries are chosen that do not include in the positive octant all the realizable (x,y) chromaticities. This leads to paradoxical adaptation predictions for the colors that have negative Von Kries coordinates. A solution is proposed here that expresses the asymmetric‐matching relation of chromatic adaptation as the product of two matrix transformations, given source illuminant 1 and destination illuminant 2: from source tristimulus values via adaptation matrix 1 to the adapted state coordinates, and from the adapted state via the inverse of adaptation matrix 2 to the destination illuminant tristimulus values. To avoid the sharpening instability, the entire spectrum locus must lie within the positive octant of the adapted state tristimulus space. © 2013 Wiley Periodicals, Inc. Col Res Appl, 39, 275–278, 2014; Published Online 14 March 2013 in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/col.21799
An open‐channel flume study of flow characteristics through a combined layer of submerged and emerged flexible vegetation
Authors: Li Yiping , Anim Desmond Ofosu , Wang Ying , Tang Chunyan , Du Wei , Yu Zhongbo , Acharya Kumud
Published: March 2013

Flowing water bodies often have plants that differ greatly in size and type, which interfere with fluid flow structure. Although there are studies describing vegetation–flow interactions in ideal laboratory conditions, their practical application is sometimes still difficult. This paper presents results of research involving laboratory simulations channel flow and the effects upon its structure as it passes through a combined layer of submerged and emerged vegetation in an open‐channel flume. Instantaneous time‐average velocity and turbulence at various locations were measured with a 3D acoustic Doppler velocimeter. The experimental results showed that the mean velocity profiles can be divided into three layers: bottom, middle and upper. The velocity profiles show the flow structure was complex variable over time creating mixing velocity layers associated with inflection points and velocity spikes. Turbulence intensity urms, vrms, wrms was nearly invariant for the flow depth at the bottom layer in most locations within the vegetation area. Maximum turbulence intensity occurred within the middle layer and migrated vertically as frontal width of the plant increased. Maximum turbulence intensity fluctuated at the velocity mixing layer where there is significant momentum exchange. The Manning's vegetation roughness coefficient n(v) due to vegetation resistance increased with vegetation density as expected. In all, the results show flow structure varies substantially at the stem section and at the canopy top of submerged vegetation. These analytical findings will be useful in understanding river channel hydraulic transport and mixing processes and useful in river engineering applications and modelling. Copyright © 2013 John Wiley & Sons, Ltd.
Synthesis of Functionalized Core–Shell CdTe/ZnS Nanoparticles and Their Application as a Fluorescence Probe for Norfloxacin Determination
Authors: Li Li , Cheng Yu , Ding Yaping , Gu Shuqing , Zhang Fenfen , Yu Weijun
Published: March 2013

A novel and simple fluorometry method has been developed and validated for the determination of norfloxacin (NOR) on the basis of the fluorescence quenching of thioglycolic acid (TGA)‐capped CdTe/ZnS nanoparticles (NPs) by NOR. The functionalized CdTe/ZnS NPs were successfully synthesized in aqueous medium with TGA as the capping ligand. TGA‐capped CdTe/ZnS NPs were characterized by using X‐ray diffraction (XRD), transmission electron microscopy (TEM), particle size measurements, and Fourier transform infrared (FTIR) spectroscopy. Owing to a specific interaction, the fluorescence intensity of CdTe/ZnS NPs is clearly reduced in the presence of NOR. Under optimal conditions, the relative fluorescence intensity of CdTe/ZnS NPs is linearly proportional to NOR concentration from 0.2 to 140 μM with a detection limit of 0.082 μM. This probe was also successfully utilized to determine the NOR in pharmaceutical formations. The quenching mechanism was also investigated. The proposed method is simple, rapid, and practical.
Synthesis, Crystal Structure, and Magnetic Properties of a Bis‐Dinuclear Oxo‐Bridged Iron(III) Complex with p‐Sulfonatocalix[4]arene
Authors: Mattoussi Nabila , Pilet Guillaume , Novitchi Ghenadie , Meganem Faouzi , Luneau Dominique
Published: March 2013

Reaction of sodium p‐sulfonatocalix[4]arene (Na4C4AS) with iron(III) nitrate and 1,10‐phenanthroline in water affords a compound in which a coordinated p‐sulfonatocalix[4]arene anion (C4AS4–) bridges two oxo‐bridged iron(III) dinuclear units, {FeIII2(μ‐O)(H2O)5(phen)2}. The crystal structure of the compound also reveals noncoordinated C4AS4– anions and crystallization water molecules. The coordinated p‐sulfonatocalix[4]arene links the {FeIII2(μ‐O)(H2O)5(phen)2} dinuclear units through two of the four sulfonate groups in the 1,2 (syn) and 1,3 (anti) modes. The complete structure may be viewed as Fe‐hinged calixarene bicapsules. The study of the magnetic susceptibility reveals strong antiferromagnetic interactions between the iron(III) ions within the dinuclear units. Because the structural features of the two Fe–O–Fe oxo bridges are very similar, the magnetic data can be fitted well by considering one exchange coupling constant, J = –127(1) cm–1, which is in agreement with previously found values for oxo‐bridged diiron(III) complexes with similar structural features. This opens up the possibility of polynuclear complexes stabilized in water and of control of their magnetic properties.
New biobased carboxylic acid hardeners for epoxy resins
Authors: Jaillet Fanny , Desroches Myriam , Auvergne Rémi , Boutevin Bernard , Caillol Sylvain
Published: March 2013

Soybean oil was modified into a novel biobased polyacid hardener by thiol‐ene coupling with thioglycolic acid. The structure of the initial soybean oil and polyacid triglyceride was carefully analyzed using 1H NMR and titration. The thermal crosslinking reaction between acid hardener and epoxidized resin was studied by differential scanning calorimetry (DSC) and rheology. Then, the synthesized biobased acid hardener was employed as a novel curing agent for bisphenol A diglycidyl ether to elaborate new partially biobased materials. These materials, formulated in stoichiometry ratio, were characterized by DSC, thermogravimetry analyses, dynamic mechanical analyses and exhibit interesting properties for coatings.

Practical applications: The products of the chemistry described in this contribution, i.e., polyacid from soybean oil and thioglycolic acid, provide biobased building blocks for further epoxy resin syntheses by reaction with epoxy groups. The obtained epoxy resins are partially biobased and may be applied as binders and coatings.
Crystal polymorph structure determined for extra virgin olive oil
Authors: Chiavaro Emma
Published: March 2013

No literature data were available on the crystal polymorph structure associated with the crystallization/melting of TAG fractions of extra virgin olive oil until the publication of the article by Barba, Arrighetti and Calligaris in this issue of the European Journal of Lipid Science and Technology [p. 322–329]. The authors determined crystal structure of extra virgin olive oil TAGs using DSC coupled with XRD technique. These findings are of great importance as an increasing number of formulated foods (e.g. salad dressings, sauces, chilled and frozen ready‐to‐eat products) and new products are nowadays produced with this high quality vegetable oil as lipid phase. The significance of these results is underlined in this commentary.

See accompanying article by Barba et al. [p. 322–329], http://dx.doi.org/10.1002/ejlt.201200259
Synthesis and Characterization of 2D‐D‐π‐A‐Type Organic Dyes Bearing Bis(3,6‐di‐tert‐butylcarbazol‐9‐ylphenyl)aniline as Donor Moiety for Dye‐Sensitized Solar Cells
Authors: Khanasa Tanika , Jantasing Nittaya , Morada Somphob , Leesakul Nararak , Tarsang Ruangchai , Namuangruk Supawadee , Kaewin Tinnagon , Jungsuttiwong Siriporn , Sudyoadsuk Taweesak , Promarak Vinich
Published: March 2013

A series of novel 2D‐D‐π‐A‐type organic dyes, namely CCTTnA (n = 1–3), bearing bis(3,6‐di‐tert‐butylcarbazol‐9‐ylphenyl)aniline as an electron‐donor moiety (2D‐D), oligothiophene segments with a number of thiophene units from one to three units as π‐conjugated spacers (π), and cyanoacrylic acid as the electron acceptor (A) were synthesized and characterized as dye sensitizers for dye‐sensitized solar cells (DSSCs). These compounds exhibit high thermal and electrochemical stability. Detailed investigations of these dyes reveal that both peripheral carbazole donors (2D) have beneficial influence on the red‐shifted absorption spectrum of the dye in solution and dye adsorbed on TiO2 film, and the broadening of the incident monochromatic photon‐to‐current conversion efficiency (IPCE) spectra of the DSSCs, leading to enhanced energy conversion efficiency (η). Among these dyes, CCTT3A shows the best photovoltaic performance, and a maximal incident monochromatic photon‐to‐current conversion efficiency (IPCE) value of 80 %, a short‐circuit photocurrent density (Jsc) of 9.98 mA cm–2, open‐circuit voltage (Voc) of 0.70 V, and fill factor (FF) of 0.67, corresponding to an overall conversion efficiency η of 4.6 % were achieved. This work suggests that organic dyes based on this type of donor moiety or donor molecular architecture are promising candidates for improved performance DSSCs.
Live cell refractometry based on non‐SPR microparticle sensor
Authors: Liu Chang , Chen David D. Y. , Yu Lirong , Luo Yong
Published: March 2013

Unlike the nanoparticles with surface plasmon resonance, the optical response of polystyrene microparticles (PSMPs) is insensitive to the chemical components of the surrounding medium under the wavelength‐dependent differential interference contrast microscopy. This fact is exploited for the measurement of the refractive index of cytoplasm in this study. PSMPs of 400 nm in diameter were loaded into the cell to contact cytoplasm seamlessly, and the refractive index information of cytoplasm could be extracted by differential interference contrast microscopy operated at 420 nm illumination wavelength through the contrast analysis of PSMPs images.
The new horizon in 2D electrophoresis: New technology to increase resolution and sensitivity
Authors: Moche Martin , Albrecht Dirk , Maaß Sandra , Hecker Michael , Westermeier Reiner , Büttner Knut
Published: March 2013

A principally new type of an electrophoresis setup for the second dimension of 2DE named HPE (high performance electrophoresis) has recently become available that provides excellent reproducibility much superior to traditional 2DE. It takes up ideas from early beginnings of 2DE which could not be satisfactory realized at that time. The new HPE system is in contrast to all other established systems a horizontal electrophoresis that employs a new type of precast polyacrylamide gels on film‐backing and runs on a multilevel flatbed electrophoresis apparatus. In a systematic approach we compared its features to traditional 2DE for the cytosolic proteome of Bacillus subtilis. Not only the reproducibility is enhanced, but also nearly all qualitative parameters as resolution, sensitivity, the number of protein spots (25% more), and the number of different proteins (also additional 25%) are markedly increased. More than 200 proteins were exclusively found in HPE. This new electrophoresis system does not use buffer tanks. No glass plates are needed. Therefore handling of gels is greatly facilitated and very simple to use even for personnel with low technical skills. The new HPE system is technically at the beginnings and further development with increased performance can be expected.
Molecular models of the cardiorenal syndrome
Authors: Heinzel Andreas , Fechete Raul , Mühlberger Irmgard , Perco Paul , Mayer Bernd , Lukas Arno
Published: March 2013

Molecular profiling techniques have provided extensive sets of molecular features characterizing clinical phenotypes, but further extrapolation to mechanistic molecular models of disease pathophysiology faces major challenges. Here, we describe a computational procedure for delineating molecular disease models utilizing omics profiles, and exemplify the methodology on aspects of the cardiorenal syndrome describing the clinical association of declining kidney function and increased cardiovascular event rates. Individual molecular features as well as selected molecular processes were identified as linking cardiovascular and renal pathology as a combination of cross‐organ mediators and common pathophysiology. The molecular characterization of the disease presents as a set of molecular processes together with their interactions, composing a molecular disease model of the cardiorenal syndrome. Integrating omics profiles describing aspects of cardiovascular disease and respective profiles for advanced chronic kidney disease on molecular interaction networks, computation of disease term‐specific subgraphs, and complemented by subgraph segmentation allowed delineation of disease term‐specific molecular models, at their intersection providing contributors to cardiorenal pathology. Building such molecular disease models allows in a generic way to integrate multi‐omics sources for generating comprehensive sets of molecular processes, on such basis providing rationale for biomarker panel selection for further characterizing clinical phenotypes.