bluuebunny/crossref_metadata_2025 huggingface dataset:
Shipi Shugan Decoction Protected against Sequela of Pelvic Inflammatory Disease via Inhibiting SIRT1/NLRP3 Signaling Pathway in Pelvic Inflammatory Disease Rats
Authors: Wang Yan , Huang Yefang , Shi Ling , Huang Li , Wen Yi , Cao Yihong , Yang Zi , Liu Qian , Yin Xiaolan , Ji Xiaoli
Published: September 2022

Sequela of pelvic inflammatory disease (SPID) is a common and frequently occurring disease clinically. Traditional Chinese medicine (TCM) provided unique advantages in the treatment of SPID. In this study, we aimed to investigate the protective mechanism of Shipi Shugan Decoction (SSD), a Chinese herbal formula, on SPID using a SPID rat model. Mixed bacterial infection and mechanical injury were used for modeling. The chemical composition of SSD was analyzed by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). The inflammatory factors were detected by enzyme-linked immunosorbent assay (ELISA) and western blot techniques. We found that SSD dose-dependently inhibited the content of IL-18, IL-1β, TNF-α, and IL-6 in serum samples of SPID rats. The results from the hematoxylin and eosin (H&E) stain showed that SSD improved pathological injury of the uterus and fallopian tubes induced by a pathogen. In addition, SSD dose-dependently inhibited mitochondrial dysfunction and oxidative stress of SPID rats. The expression of SIRT1 was promoted, and NLRP3 inflammasome was deactivated by SSD gavage compared with the SPID group. Specifically, SIRT1 inhibitor EX-527 cotreatment significantly reversed the improvement effect of SSD on pelvic inflammatory disease in rats. Taken together, the results of this study suggest that Shipi Shugan Decoction may be an effective TCM for the treatment of SPID.
Research on How External Environment Influences Digitalization of Cultural Enterprises
Authors: Ji Hao , Pang Yu , Suo Lingling , Wang Tongtong
Published: September 2022

Digitalization is critical to the growth of cultural industry today. However, existing research has not explained the mechanism by which the external environment affects the digitalization of cultural enterprises. Based on structural equation modeling, we tested the model empirically using data from 295 cultural enterprises in Beijing. The results show that two external environmental variables, the market pressure and the government’s supportive policies, have a positive impact on the adoption of digitalization in cultural enterprises through technical and organizational factors. The research conclusion explains how the external environment influences digitalization in cultural enterprises. Technological factors of digitalization capability and digitalization compatibility and organizational factors of perceived benefits play a mediating role between the external environment and the digitalization of cultural enterprises. Based on these conclusions, we finally put forward a series of countermeasures to enhance the digitalization of cultural enterprises.
Remaining Oil Distribution and Development Strategy for Offshore Unconsolidated Sandstone Reservoir at Ultrahigh Water-Cut Stage
Authors: Liu Chen , Zhou Wensheng , Jiang Junzhe , Shang Fanjie , He Hong , Wang Sen
Published: September 2022

Due to the influence of long-term waterflooding, the reservoir physical properties and percolation characteristics tend to change greatly in offshore unconsolidated sandstone reservoirs at ultrahigh water-cut stage, which can affect the remaining oil distribution. Remaining oil characterization and proper development strategy-making are of vital importance to achieve high-efficiency development of mature reservoirs. The present numerical simulation method is difficult to apply in reservoir development due to the problems of noncontinuous characterization and low computational efficiency. Based on the extended function of commercial numerical simulator, the time-varying equivalent numerical simulation method of reservoir physical properties was established, and the research of numerical simulation of X offshore oilfield with 350,000 effective grids was completed. The results show that the time-varying reservoir properties have a significant impact on the distribution of remaining oil in ultrahigh water-cut reservoir. Compared with the conventional numerical simulation, the remaining oil at the top of main thick reservoir in X oilfield has increased by 18.5% and the remaining oil in the low-permeability zone at the edge of the nonmain reservoir has increased by 27.3%. The data of coring well and the implementation effect of measures in the X oilfield are consistent with the recognition of numerical simulation, which proves the rationality of numerical simulation results. The new method is based on a mature commercial numerical simulator, which is easy to operate and has reliable results.
Efficacy Evaluation of the Combined Platelet-Rich Plasma and Hyaluronic Acid after Arthroscopic Joint Debridement in Treating Knee Osteoarthritis
Authors: Lu Min , Jin Yanquan
Published: September 2022

Objective. The study is aimed at observing the efficacy of the combined platelet-rich plasma and hyaluronic acid after arthroscopic joint debridement in treating knee osteoarthritis (KOA). Methods. 126 patients with KOA admitted to the Affiliated People’s Hospital of Ningbo University and Taizhou Orthopaedic Hospital from 2018-11 to 2021-11 were selected. All nominees were grouped by random drawing; group B (63 cases) received arthroscopic joint debridement while group A (63 cases) received platelet-rich plasma and hyaluronic acid based on group B. The following metrics are counted, including total efficiency, knee joint pain and function, inflammatory cytokines levels, and oxidative stress indicator levels; the complication rate is counted. Results. The total effective rate of group A (93.65%) was higher than that of group B (77.78%) (

P
<
0.05

), and there was no significant difference in the incidence of complications between the groups (

P
>
0.05

). Three months after treatment, knee joint pain and function, inflammatory cytokine levels, and oxidative stress indicators levels in group A were better than in group B (

P
<
0.05

). Conclusion. The combined platelet-rich plasma and hyaluronic acid after arthroscopic joint debridement in treating KOA can achieve significant effects, reduce knee pain, accelerate the recovery of knee joint function, relieve inflammation, and inhibit oxidative stress and has high safety.
Association between Folic Acid Supplementation and Hypertensive Disorder Complicating Pregnancy in Jiangsu Province: A Cross-Sectional Study
Authors: Cong Jing , Pu Danhua , Tan Rongrong , Ge Xiaoyun , Zhu Weipei , Shen Cai-e , Ge Jianfen , Luo Xiucui , Liu Juan , Wu Jie
Published: September 2022

Objectives. To investigate the association of folic acid (FA) supplementation with hypertensive disorder complicating pregnancy (HDCP) and preeclampsia in Jiangsu Province, China. Materials and Methods. In this cross-sectional study, a total of 10,662 women with infants born between January 2017 and December 2018 were enrolled in Jiangsu Province, China. Maternal women with and without FA supplement intake were compared in this study. FA supplementation included 0.4 mg FA (0.4 FA), multivitamins with 0.4 mg FA (multivitamin (MV)+0.4 FA), and multivitamins with 0.8 mg FA (MV + 0.8 FA). Associations between FA intake, FA supplement dose or duration, (MV + FA) dosage per weight, and HDCP were analysed using ANOVA, the chi-square test, and logistic regression analysis. Results. Over the study follow-up period, the incidences of HDCP and preeclampsia were 3.5%, 1.4%, and 2.2%, 0.6% in the non-FA supplementation and FA supplementation groups, but only 1.5% and 0.1% in the MV + 0.8 FA group in early pregnancy. Compared with the non-FA group, HDCP and preeclampsia had the lowest risk in the MV + 0.8 FA group among the seven FA supplementation groups (HDCP: RR = 0.42, 95% CI = 0.27-0.68,

P
=
0.001

; preeclampsia: RR = 0.09, 95% CI = 0.03–0.33,

P
=
0.001

) in early pregnancy. Compared with the 0.4 FA alone group, the risk of HDCP and preeclampsia in women taking MV + 0.8 FA was significantly reduced (RR = 0.60, 95% CI = 0.41–0.87,

P
=
0.008

; preeclampsia: RR = 0.18, 95% CI = 0.06–0.60,

P
=
0.005

) in early pregnancy. (MV + FA)/BMI supplementation was associated with the risk of HDCP in early pregnancy (

P

trend = 0.002). Conclusions. MV supplement with 0.8 mg FA during early pregnancy may be effective in reducing HDCP and preeclampsia risk. The study provided the viewpoint that (MV + FA)/BMI could be used as a reference for FA intake in pregnant women of different weights.
Use of Mirtazapine and Olanzapine in the Treatment of Refractory Hyperemesis Gravidarum: A Case Report and Systematic Review
Authors: Galletta Marco Aurélio Knippel , Tess Vera Lucia Carvalho , Pasotti Isabela Marangon , Pelegrini Luiza Fior , Ribeiro Rocha Nicole Kemberly , Testa Carolina Burgarelli , Francisco Rossana Pulcineli Vieira
Published: September 2022

Hyperemesis gravidarum (HG) is a rare condition (1.1%) characterized by excessive vomiting, malnutrition, dehydration, and laboratorial alterations. Herein, we describe the even rarer and serious presentation of refractoriness to the usual treatment of antiemetics and parenteral nutrition, with improvement only after the use of olanzapine and mirtazapine. Two subsequent pregnancies of the same woman with HG are described, which were associated with severe weight loss, anemia, hyponatremia, hypokalemia, and mild dysfunction of liver enzymes. In the third pregnancy, the usual treatment for HG was not successful, requiring enteral nutrition and the introduction of olanzapine. In the fourth pregnancy, the patient refused to use enteral nutrition for refractory HG. Hence, the patient was started on mirtazapine at an initial dose of 15 mg/day, which was gradually increased to 30 mg/day. The patient responded well to the new regimen, as demonstrated by the decrease in symptoms, the gain of 10 kg in the pregnancy, and delivering a healthy newborn. A systematic review of literature showed 11 articles and 30 cases that successfully used mirtazapine in HG. Good clinical outcomes were seen with 4 days of the treatment and at an initial dose of 15 mg/day. However, most of these reports were from psychiatric profiles, with a predominance of depression and anxiety symptoms, and a poor description of the obstetric conditions and the disease progression itself. Pulmonary hypertension was described in one case and neonatal hyperexcitability in another. The case described in this paper reinforces the idea that mirtazapine and olanzapine can be considered in refractory HG, with good results. In the world literature, this is the second case of HG that has been successfully treated with olanzapine and the first in Latin America treated with mirtazapine.
The Biomechanical Analysis of Jumping Difficulty Movement in National Traditional Sports
Authors: Zhang Linbao , Yang Wei
Published: September 2022

In order to explore the relevant factors and the completion of difficult movements, this paper is an important theoretical basis for improving and constructing the evaluation of athletes’ movement quality. It presents a kinematic analysis of the difficult movements of competitive Tai Chi, taking the difficult movements of the swirl group of competitive aerobics as the research object. The data is collected by different methods. When completing difficult movements, due to different personal exercise habits, this paper takes the right leg as the swinging leg and the left leg as the take-off leg when completing the difficult movements. The test object in this paper adopts the traditional three-step up-step method. The starting time of the take-off stage is consistent with the illustration. By consulting experts for the stage division of the difficult movement, the two movement stages are equally divided into three stages according to the needs of the research: take-off, soaring, and landing. The results show that, from the moment the left foot hits the ground to the moment of maximum cushioning, the angles of the right knee are 176.48° and 165.06°, respectively, and the flexion of the right knee is not large; especially when the left foot touches the ground, the right leg is close to a straight line, indicating that the athlete’s body is in a straight line. The posture is relatively good, the left foot is used as the grounding leg, the angle of the knee joint is reduced from 160.82° to 124.41°, and the left knee buffer angle is 36.40°. As the right leg swings to the ground, the left knee and left hip are slightly stretched, and the right knee and right hip are slightly flexed. This change is also reflected in the fact that the center of gravity changes from the direction of the horizontal speed at this stage. Move the left side of the body slightly to the right. Difficulty movements are different in the landing stage, and their joint parameters are also different. When the landing leg touches the ground, there is no significant difference in the maximum cushioning time, the degree of torsion of the shoulder and the hip is different, the relative rotation position of the shoulder and the hip is opposite, and the posture of the shoulders at the time of landing is different. In teaching, the landing leg and the end direction of the rotation are not the same; it is necessary to strengthen the strength training of the legs, to experience the force feeling of the different degrees of rotation of the shoulder joint and the hip joint, as well as the spatial perception ability, and take the initiative to actively land. The magnitude of the rear cushion and the coordination of the trunk and the limbs are used to avoid unnecessary damage during the landing phase.
The Existence of Multiple Periodic Solutions to a Class of Fourth-Order Difference Equations
Authors: Wu Haoxin , Tan Zixian , Hu Xinfei , Xiao Huafeng
Published: September 2022

In this paper, we study the multiplicity of periodic solutions for a class of fourth-order difference equations. We estimate a lower bound on the number of periodic solutions when the nonlinearity is asymptotic both at the origin and at infinity. Our results generalize the reference’ results.
Treatment of Tanning Effluent Using Seaweeds and Reduction of Environmental Contamination
Authors: Sampathkumar V. , Southamirajan S. , Subramani Elango , Veerasamy Senthilkumar , Ambika D. , Gopalakrishnan Dineshkumar , Arunkumar G. E. , Raja K. , Arulmozhi S. , Balamoorthy Dhivya
Published: September 2022

One of the main sources of dangerous chemicals that are dumped untreated into land and water bodies and have a negative influence on the ecosystem are industrial effluents. Seaweeds are currently used for treating industrial effluent effectively. The technology is at a maturing stage. This paper reviews the characterization and cultivation of seaweeds for wastewater treatment. In this present study, different extracts of four seaweeds such as Gracilaria edulis, Sargassum wightii, Turbinaria ornata, and Kappaphycus alvarezii, from the Mandapam coastal regions were analyzed. The seaweeds are used to treat the leather industry effluents collected from EKM leather processing company, Erode, Tamil Nadu, India. Among all, extracts of Gracilaria edulis survived at different concentrations of TDS: 15,000, 25000, and 35000 mg/l. Out of these different ranges, TDS of about 25000 mg/l seaweed named Gracilaria edulis reduced more amounts of chemicals present in the effluent like TDS (93.90%), phosphates (72.71%), nitrate (75.08%), nitrite (76.92%), and turbidity (99.01%) content. Additionally, we produce the quality and strength of agar gel from the cultivation of Gracilaria edulis by the Nikansui method. Finally, we got the extraction procedure to obtain a higher yield of about 10.26% and a maximum gel strength of 92.06 g·cm−2 while maintaining the melting point at 78°C.
Radioactive Iodine Ablation Can Reduce the Structural Recurrence Rate of Intermediate-Risk Papillary Thyroid Microcarcinoma: A Meta-Analysis
Authors: Zhao Min , Shi Xinyu , Zhang Jing , Deng Shengming , Zhou Yeye , Wen Runze , Lu Yixing , Zhang Bin
Published: September 2022

Background. The incidence of papillary thyroid microcarcinoma (PTMC) has significantly increased in recent years, and the decision to use radioactive iodine (RAI) ablation in low-risk (LR) and intermediate-risk (IR) patients is controversial. The aim of this study was to evaluate whether RAI ablation can reduce the recurrence rate in LR-IR PTMC patients. Methods. A comprehensive literature search of the PubMed, Embase, Cochrane Library, and Web of Science was conducted according to the PRISMA statement. Results. There were 8 studies in English that fit our search strategy, and a total of 2847 patients were evaluated. The results of the meta-analysis showed RAI ablation in LR-IR PTMC patients did not reduce cancer recurrence (risk radio (RR) 0.56, 95% CI 0.19-1.70,

P
=
0.31

). Nevertheless, we further performed data analysis and found that IR PTMC patients without RAI ablation had a higher rate of cancer recurrence than those who underwent RAI ablation (RR 0.23, 95% CI 0.11-0.49,

P
=
0.0001

). Furthermore, patients with risk factors for lymph node metastasis (RR 0.16, 95% CI 0.06-0.42,

P
=
0.0002

), microscopic extrathyroidal extension (RR 0.19, 95% CI 0.06-0.60,

P
=
0.005

), and multifocality (RR 0.13, 95% CI 0.04-0.45,

P
=
0.001

) in the absence of RAI ablation were more likely to have recurrence. Conclusions. Based on our current evidence, RAI ablation can reduce the cancer recurrence rate over 5 years in IR PTMC patients, especially when patients have some risk factors, such as lymph node metastasis, microscopic extrathyroidal extension, and multifocality.
Use IoT in Physical Education and Sport in China Schools
Authors: Liang Yongqing , Guo Han , Yi Huiheng
Published: September 2022

While the school sports program model is typically established in secondary schools, it has received much less attention paid to physical training at the university. In this study, 110 Chinese university students were split into six groups. One group used sport education, and the other used a more traditional teacher-directed approach. Pupils were tested on how well they could play games, how well they did, and how much they knew. All of the people got better over the course of a 16-week period. People who went to sports high school got better grades than people who did not go to sports high school. Students may be encouraged to achieve the goals of Chinese university physical education by the highlights of sport education that have been displayed to spur understudies in past investigations (for example, being important for a group, contending in a way that is formatively suitable, and taking on different jobs). PES might have the option to make a one of a kind commitment to the improvement of youngsters’ fundamental development abilities and actual capacities, which are significant antecedents to partaking in later way of life and donning proactive tasks further down the road. Interactive abilities and conduct, confidence, and preschool perspectives might benefit from outside input when they are introduced in the correct manner. At times, they can likewise assist with scholastic and mental turn of events. Audit: many of these advantages will not come from simply participating in sports. They will be influenced by the way students and their teachers, parents, and coaches who work with them work together. Physical activities that take place in environments that emphasise positive experiences, diversity, and everyone’s involvement and that are run by teachers and coaches who are committed and trained, as well as parents who are supportive and informed, can have a big impact on how these activities turn out and how likely they are to have positive effects.
Relationship between Self-Efficacy and Headache Impact, Anxiety, and Physical Activity Levels in Patients with Chronic Tension-Type Headache: An Observational Study
Authors: González de la Flor Ángel , García Pérez de Sevilla Guillermo , Domíngez Balmaseda Diego , Martín Vera Daniel , Montero Martínez María , Del Blanco Muñiz Jose Ángel
Published: September 2022

Background. Chronic tension-type headache is the primary headache with the highest prevalence. The present study is aimed at analyzing the associations between patient self-efficacy and headache impact with pain characteristics, kinesiophobia, anxiety sensitivity, and physical activity levels in subjects with chronic tension-type headache. Materials and Methods. An observational descriptive study was carried out. A total sample of 42 participants was recruited at university environment with diagnosis of tension-type headache. Headache characteristics (frequency, intensity, and duration), physical activity levels, pain related-self-efficacy, kinesiophobia, anxiety sensitivity, and headache impact were measured. Results. The HIT-6 (

61.05
±
6.38

) score showed significant moderate positive correlations with the ASI-3 score (

17.64
±
16.22

;

r
=
0.47

) and moderate negative correlations with the self-efficacy in the domains of pain management (

31.9
±
10.28

;

r
=
−
0.43

) and coping with symptoms (

53.81
±
14.19

;

r
=
−
0.47

). ASI-3 score had a negative large correlation with self-efficacy in the domains of pain management (

r
=
−
0.59

), physical function (

53.36
±
7.99

;

r
=
−
0.55

), and coping with symptoms (

r
=
−
0.68

). Physical activity levels showed positive moderate correlations with the self-efficacy in the domain of physical function (

r
=
0.41

). Linear regression models determined that the self-efficacy and anxiety sensitivity with showed a significant relationship with the HIT-6 score (

R

2

=
0.262
;
p
=
0.008

) and with the ASI-3 score (

R

2

=
0.565

;

p
<
0.001

). In addition, no correlations were found between pain intensity, duration or frecuency with psychosocial factors, or headache impact. Conclusions. The present study showed that patients with chronic tension-type headache had a great negative impact on daily tasks and physical activity levels, which were associated with higher anxiety levels and lower self-efficacy.
Design and Application of Yoga Intelligent Teaching Platform Based on Internet of Things
Authors: Fu Dong , Wang Jian
Published: September 2022

With the rapid development of economy, science, and technology, people’s pursuit of quality of life continues to improve, leisure sports have gradually become a trend, and yoga, as a traditional and fashionable way of fitness, is favored by more and more people. However, the traditional training class yoga teaching time is fixed, which will have many inconveniences for professionals. However, learning according to the teaching video cannot guarantee the accuracy of the movement and may not achieve the training effect. Therefore, in this situation, intelligent e-yoga teaching is of great significance to improve the training level. This system is based on Internet of things technology, selects Kinect as the sensing carrier of human motion information, and designs an electronic yoga teaching system. The system integrates the functions of motion information acquisition and motion evaluation. First, standard yoga movements are collected through Kinect as a comparison template for yoga training. Second, the system collects the trainers’ action data, uses Hausdorff distance algorithm to evaluate the similarity of action flow, and identifies the action name based on the threshold. Third, through the motion evaluation algorithm based on joint point angle measurement, it points out the joint points whose actions are not in place. Based on the completion time of the action, the action speed is evaluated. Finally, the system outputs the evaluation results in the form of text and voice through text conversion technology. The system can carry out efficient posture recognition and can achieve the purpose of evaluating the training quality and giving guiding suggestions. It can meet the basic training needs of users and has great application value.
Computational Modeling of the Bent Antenna in an On-Body Mode Using the Cylindrical TLM Approach
Authors: Joković Jugoslav J. , Dimitrijević Tijana Z. , Atanasković Aleksandar S. , Dončov Nebojša S.
Published: September 2022

This paper presents the suitability and computational features of the cylindrical TLM approach, when it is used as an accurate and efficient alternative for the analysis of the bending effect on performances of the antenna operating in an on-body mode. A design goal was to create the model of the rectangular patch antenna wrapped around the part of a cylinder, which can be used to represent a human body (torso, leg, or arm) and simultaneously to model dielectric properties of muscle tissue. Moreover, the paper illustrates problems in terms of accuracy and limitations when the antenna deformation is modelled by using numerical methods based on the cubic mesh. The advantages of the cylindrical TLM method over the rectangular TLM approach have been emphasized through an analysis of how the bending affects the resonant frequency of the antenna.
Study on Performance of Infilled Wall in an RC-Framed Structure Using a Reinforcing Band
Authors: Jagadeesan P. , Sudharsan N. , Subash S.M. , Thirumoorthy Pradeep , Sugumaran B. , Bari Jabar Abdul , Vetturayasudharsanan R. , Ambika D. , Sharmiladevi K. , Karuppanan Kathiresan
Published: September 2022

Infilled wall is a primary structure which is used in a multistorey RC-framed structure. It is not designed like structural elements, but it is subjected to structural load and response as a heavily damaged element into the building. The main problem of an infilled wall is not actively utilizing in the framed structure and it is not interacted with frame elements. The objective of research is to utilize the infilled wall in the RC-framed structure by improving its performance of behavior. Here, two different types of brick masonry like Autoclaved concrete and clay brick masonry were used as the infilled wall in an RC-framed structure. A singly bay and single storey RC framed structure was cast and tested under a 1/10th scale model by diagonal compressive loading. The specimen was subjected to static loading by a universal testing machine. Infilled wall is weak in tension, so a reinforcing band was used to improve the performance like load carrying capacity, stiffness, ductility, and energy dissipation capacity. Based on the results of the experimental study, it is found that reinforcing band with the infilled wall gives better behavior of the RC-framed structure.
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID‐19 among Patients from Rio de Janeiro, Brazil
Authors: de Sá Nathalia Beatriz Ramos , Neira-Goulart Milena , Ribeiro-Alves Marcelo , Perazzo Hugo , Geraldo Kim Mattos , Ribeiro Maria Pia Diniz , Cardoso Sandra Wagner , Grinsztejn Beatriz , Veloso Valdiléa G. , Capão Artur , Siqueira Marilda Mendonça , de Lima Bezerra Ohanna Cavalcanti , Garcia Cristiana Couto , Gomes Larissa Rodrigues , da Silva Cazote Andressa , de Almeida Dalziza Victalina , Giacoia-Gripp Carmem Beatriz Wagner , Côrtes Fernanda Heloise , Morgado Mariza Gonçalves
Published: September 2022

COVID‐19 has a broad spectrum of clinical manifestations, from asymptomatic or mild/moderate symptoms to severe symptoms and death. The mechanisms underlying its clinical evolution are still unclear. Upon SARS‐CoV‐2 infection, host factors, such as the inflammasome system, are activated by the presence of the virus inside host cells. The search for COVID‐19 risk factors is of relevance for clinical management. In this study, we investigated the impact of inflammasome single‐nucleotide polymorphisms (SNPs) in SARS‐CoV‐2‐infected individuals with distinct severity profiles at clinical presentation. Patients were divided into two groups according to disease severity at clinical presentation based on the WHO Clinical Progression Scale. Group 1 included patients with mild/moderate disease (WHO < 6; n = 76), and group 2 included patients with severe/critical COVID‐19 (WHO ≥ 6; n = 357). Inpatients with moderate to severe/critical profiles were recruited and followed‐up at Hospital Center for COVID‐19 Pandemic – National Institute of Infectology (INI)/FIOCRUZ, RJ, Brazil, from June 2020 to March 2021. Patients with mild disease were recruited at Oswaldo Cruz Institute (IOC)/FIOCRUZ, RJ, Brazil, in August 2020. Genotyping of 11 inflammasome SNPs was determined by real‐time PCR. Protection and risk estimation were performed using unconditional logistic regression models. Significant differences in NLRP3 rs1539019 and CARD8 rs2043211 were observed between the two groups. Protection against disease severity was associated with the A/A genotype (ORadj = 0.36; P = 0.032), allele A (ORadj = 0.93; P = 0.010), or carrier‐A (ORadj = 0.45; P = 0.027) in the NLRP3 rs1539019 polymorphism; A/T genotype (ORadj = 0.5; P = 0.045), allele T (ORadj = 0.93; P = 0.018), or carrier‐T (ORadj = 0.48; P = 0.029) in the CARD8 rs2043211 polymorphism; and the A‐C‐G‐C‐C (ORadj = 0.11; P = 0.018), A‐C‐G‐C‐G (ORadj = 0.23; P = 0.003), C‐C‐G‐C‐C (ORadj = 0.37; P = 0.021), and C‐T‐G‐A‐C (ORadj = 0.04; P = 0.0473) in NLRP3 genetic haplotype variants. No significant associations were observed for the other polymorphisms. To the best of our knowledge, this is the first study demonstrating an association between CARD8 and NLRP3 inflammasome genetic variants and protection against COVID‐19 severity, contributing to the discussion of the impact of inflammasomes on COVID‐19 outcomes.
[Retracted] Efficacy of Shuanghe Jiyu Decoction in 126 Patients with Bone Marrow Suppression
Authors: Yao Dapeng , Zhao Jing , Ren Yanling
Published: September 2022

Bone marrow suppression is a common complication of chemotherapy. In order to observe the effects of Shuanghe Jiyu decoction on peripheral white blood cells (WBC), hemoglobin (Hb), and platelet (PLT) in patients with bone marrow suppression, a total of 126 patients with bone marrow suppression were given at least three consecutive cycles of chemotherapy. The results show that among 126 patients with bone marrow suppression, 16 achieved marked efficacy and 100 achieved moderate efficacy. The overall effective rate is 92.06%. Moreover, the symptoms of bone marrow suppression are mitigated. No adverse events are reported during the treatment.
Research and Application of Computer Collaborative Spectrum Sensing Guided by Radio Technology
Authors: Mu Shaohua
Published: September 2022

Currently, due to the proliferation of smart appliances and the rapid development of wireless communication technologies, there is a huge shortage of spectrum resources. Cognitive radio utilizes technologies that dramatically increase the utilization of free frequency bands, detecting the environment in real time and maximizing the reallocation of spectrum resources by sensing and reallocating the licensed free frequency bands. The frequency and accuracy required to determine the free bands is an important basis for determining the spectrum awareness in all aspects of a sensing radio system. Therefore, for the more complex network environment in reality and the intrusion of malicious users, this paper uses Fast K-medoids and Mean-shift methods for information fusion and an iterative approach to overcome malicious use to fuse data and finally obtain realistic feature statistics. The results show that the collaborative identification strategy proposed in this paper has good results.
Presepsin Predicts Severity and Secondary Bacterial Infection in COVID-19 by Bioinformatics Analysis
Authors: Chang Yufei , Liu Linan , Wang Hui , Liu Jinghe , Liu Yuwei , Du Chunjing , Hua Mingxi , Liu Xinzhe , Liu Jingyuan , Li Ang
Published: September 2022

Introduction. Novel coronavirus pneumonia (COVID-19) is an acute respiratory disease caused by the novel coronavirus SARS-CoV-2. Severe and critical illness, especially secondary bacterial infection (SBI) cases, accounts for the vast majority of COVID-19-related deaths. However, the relevant biological indicators of COVID-19 and SBI are still unclear, which significantly limits the timely diagnosis and treatment. Methods. The differentially expressed genes (DEGs) between severe COVID-19 patients with SBI and without SBI were screened through the analysis of GSE168017 and GSE168018 datasets. By performing Gene Ontology (GO) enrichment analysis for significant DEGs, significant biological processes, cellular components, and molecular functions were selected. To understand the high-level functions and utilities of the biological system, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was performed. By analyzing protein-protein interaction (PPI) and key subnetworks, the core DEGs were found. Results. 85 DEGs were upregulated, and 436 DEGs were downregulated. The CD14 expression was significantly increased in the SBI group of severe COVID-19 patients (

P
<
0.01

). The area under the curve (AUC) of CD14 in the SBI group in severe COVID-19 patients was 0.9429. The presepsin expression was significantly higher in moderate to severe COVID-19 patients (

P
<
0.05

). Presepsin has a diagnostic value for moderate to severe COVID-19 with the AUC of 0.9732. The presepsin expression of COVID-19 patients in the nonsurvivors was significantly higher than that in the survivors (

P
<
0.05

). Conclusion. Presepsin predicts severity and SBI in COVID-19 and may be associated with prognosis in COVID-19.
HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis
Authors: Mou Jiahui , Huang Meijun , Wang Feifei , Xu Xiaoding , Xie Hanqi , Lu Henglei , Li Mingyang , Li Yu , Kong Weiwen , Chen Jing , Xiao Ying , Chen Yiding , Wang Chaochen , Ren Jin
Published: September 2022

Cancer progression is highly dependent on the ability of cancer cell tumor formation, in which epigenetic modulation plays an essential role. However, the epigenetic factors promoting breast tumor formation are less known. Screened from three-dimensional (3D)-sphere tumor formation model, HMGN5 that regulates chromatin structures became the candidate therapeutic target in breast cancer, though its role is obscure. HMGN5 is highly expressed in 3D-spheres of breast cancer cells and clinical tumors, also an unfavorable prognostic marker in patients. Furthermore, HMGN5 controls tumor formation and metastasis of breast cancer cells in vitro and in vivo. Mechanistically, HMGN5 is governed by active STAT3 transcriptionally and further escorts STAT3 to shape the oncogenic chromatin landscape and transcriptional program. More importantly, interference of HMGN5 by nanovehicle-packaged siRNA effectively inhibits tumor growth in breast cancer cell–derived xenograft mice model.

Implications:

Our findings reveal a novel feed-forward circuit between HMGN5 and STAT3 in promoting breast cancer tumorigenesis and suggest HMGN5 as a novel epigenetic therapeutic target in STAT3-hyperactive breast cancer.
Abstract IA25: Human genetic studies: CLL and transformation
Authors: Wu Catherine J
Published: September 2022

Across cancers, histologic transformation remains a major challenge due to its association with rapid tumor progression and resistance. This is well-exemplified by Richter syndrome (RS) – the occurrence of an aggressive lymphoma of dismal prognosis in patients with chronic lymphocytic leukemia (CLL). RS is now a major obstacle to long-term CLL cure since the targeted agents developed for CLL have failed to either prevent or treat RS. In short, RS is becoming a frequent mode of progression and escape through therapeutic resistance. Thus far, definitive evolutionary studies and understanding of the genomic basis of transformation have yet to be completed. Major challenges towards this goal include the very fact that patient biopsy specimens contain an admixture of both CLL and RS tumor cells within the same tumor microenvironment, thereby limiting reliable investigations of RS cells. For CLL, large-scale sequencing studies have successfully demonstrated the diverse spectrum of recurrent gene mutations associated with CLL and the high level of genetic heterogeneity amongst patient samples, consistent with the high degree of clinical variability that is characteristic of this malignancy. We will review new studies to integrate multiple data layers in a cohort of >1000 patients, providing us with a ‘CLL map.’ Recently, we have been developing highly novel analytics that allow us to discern, within a sample that is admixed with both CLL and RS cells, the contributions of CLL vs that of RS. In doing so, we are able to identify new drivers and molecular subtypes of RS, and profile the trajectory from CLL to RS. Such studies are paradigm shifting for the clinic in relationship to both detection, diagnosis and prognosis of RS, and advances our efforts to attain a molecular definition of RS. Moreover, the methodologies, conclusions and detailed studies presented in our work are highly relevant to other hematologic malignancies and solid tumors.

Citation Format: Catherine J Wu. Human genetic studies: CLL and transformation [abstract]. In: Proceedings of the Third AACR International Meeting: Advances in Malignant Lymphoma: Maximizing the Basic-Translational Interface for Clinical Application; 2022 Jun 23-26; Boston, MA. Philadelphia (PA): AACR; Blood Cancer Discov 2022;3(5_Suppl):Abstract nr IA25.
Dyspnoe-Symptomatik in der Notaufnahme: PoC-Sonographie als Investition in Diagnosestellung und Patientenversorgung
Authors: Sofianos Georgios
Published: September 2022

Background: Dyspnea is one of the common symptoms patients present to the emergency department (ED). The broad spectrum of differentials often requires laboratory and radiological testing in addition to clinical evaluation, causing unnecessary delay. Point of care ultrasound (PoCUS) has shown promising results in accurately diagnosing patients with dyspnea, thus, becoming a popular tool in ED while saving time and maintaining safety standards. Our study aimed to determine the utilization of point of care ultrasound in patients with acute dyspnea as an initial diagnostic tool in our settings. Method: ology: The study was conducted at the emergency department of a tertiary healthcare center in Northern India. Adult patients presenting with acute dyspnea were prospectively enrolled. They were clinically evaluated and necessarily investigated, and a provisional diagnosis was made. Another EP, trained in PoCUS, performed the scan, blinded to the laboratory investigations (not the clinical parameters), and made a PoCUS diagnosis. Our gold standard was the final composite diagnosis made by two Emergency Medicine consultants (who had access to all investigations). Accuracy and concordance of the ultrasound diagnosis to the final composite diagnosis were calculated. The time to formulate a PoCUS diagnosis and final composite diagnosis was compared. Results: Two hundred thirty-seven patients were enrolled. The PoCUS and final composite diagnosis showed good concordance (κ = 0.668). PoCUS showed a high sensitivity for acute pulmonary edema, pleural effusion, pneumothorax, pneumonia, pericardial effusion, and low sensitivity for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and acute respiratory distress syndrome (ARDS)/acute lung injury (ALI). High overall specificity was seen. A high positive predictive value for all except left ventricular dysfunction, pericardial effusion, non-cardiopulmonary causes of dyspnea, and a low negative predictive value was seen for pneumonia. The median time to make a PoCUS diagnosis was 16 (5–264) min compared to the 170 (8–1346) min taken for the final composite diagnosis. Thus, time was significantly lower for PoCUS diagnosis (p value <0.001). Conclusion: By combining the overall accuracy of PoCUS, the concordance with the final composite diagnosis, and the statistically significant reduction in time taken to formulate the diagnosis, PoCUS shows immense promise as an initial diagnostic tool that may expedite the decision-making in ED for patients’ prompt management and disposition with reliable accuracy.
Clinical Diagnosis of Probable Cerebral Amyloid Angiopathy: Diagnostic Accuracy Meta-Analysis of the Boston Criteria
Authors: Charidimou Andreas , Boulouis Gregoire
Published: September 2022

Background:

The Boston criteria are used widely for the noninvasive diagnosis of sporadic cerebral amyloid angiopathy (CAA) and hence clinical decision-making, as well as research in the field. Yet, their exact diagnostic accuracy and validity remain (paradoxically) poorly studied. We performed a meta-analysis to synthesize evidence on the value and accuracy of the Boston criteria in diagnosing probable CAA patients.

Methods:

In a systematic literature search, we identified studies with extractable data relevant for sensitivity and specificity of probable CAA diagnosis per the magnetic resonance imaging Boston criteria and neuropathological CAA verification. We included studies that have classified patients according to any version of the Boston criteria, based on available brain magnetic resonance imaging blood-sensitive sequences (index test) and had neuropathologic evaluation for CAA presence from brain tissue samples (diagnostic reference standard). Using a hierarchical (multilevel) logistic regression model, we calculated pooled diagnostic test accuracy for probable CAA diagnosis.

Results:

Seven studies, including 193 patients, 121 with neuropathologically verified CAA versus 72 non-CAA based on neuropathology definition, were included in the meta-analysis. The studies were of low-to-moderate quality and varied in several methodological aspects. The overall pooled sensitivity for probable CAA diagnosis was 66.7% (95% CI, 45.9%–82.6%) and specificity was 88.2% (95% CI, 68.5%–96.3%). A predefined subgroup analysis of 4 studies on Boston criteria v.1.0 (n=151) demonstrated a pooled sensitivity and specificity of 60% (95% CI, 45.1%–72.9%) and 93.1% (95% CI, 81.8%–97.6%), respectively. Five studies had data on Boston criteria v.1.5 (n=123): the pooled sensitivity and specificity for probable CAA diagnosis was 73.1% (95% CI, 45%–90.1%) and 86% (95% CI, 41.4%–98.1%), respectively.

Conclusions:

The Boston criteria v.1.0 and v.1.5 appear to have moderate-to-good diagnostic accuracy for probable CAA in symptomatic patients, with high specificity but low-to-moderate sensitivity. Data are based on limited retrospective studies of overall low quality and at high risk of bias.
A Survey on Automated Fact-Checking
Authors: Guo Zhijiang , Schlichtkrull Michael , Vlachos Andreas
Published: September 2022

Fact-checking has become increasingly important due to the speed with which both information and misinformation can spread in the modern media ecosystem. Therefore, researchers have been exploring how fact-checking can be automated, using techniques based on natural language processing, machine learning, knowledge representation, and databases to automatically predict the veracity of claims. In this paper, we survey automated fact-checking stemming from natural language processing, and discuss its connections to related tasks and disciplines. In this process, we present an overview of existing datasets and models, aiming to unify the various definitions given and identify common concepts. Finally, we highlight challenges for future research.
Effects of Plant Spacing with Companion Plants on Growth and Fruit Quality of Cherry Tomatoes
Authors: Lee Byoung-Kwon , Yun Hyung-Kwon , Hong In-Kyoung , Jung Young-Bin , Lee Sang-Mi , Lee Sang-Deok
Published: September 2022

Background and objective: This study was conducted to identify various factors of plant spacing for the growth and fruit quality of cherry tomatoes and to contribute to urban agriculture by improving quality and providing appropriate fertilization methods.Methods: French marigold (Tagetes patula, T), zinnia (Zinnia elegans, Z), spearmint (Mentha spicata, M), and basil (Ocimum basilicum, O), which have a combination effect with cherry tomatoes (Lycopersicon esculentum), were selected and tested by applying 10, 20, and 40 cm of plant spacing. Cherry tomatoes were planted in the middle of the furrow without companion plants, repeated three times for each experimental section. The growth survey included plant height, stem thickness, total number of fruits per plant, total fresh weight of fruits, fruit hardness, sugar content, and vitamin C. The inorganic constituents of plants were divided into roots, stems, and leaves.Results: There were statistical differences in stem thickness and total number of fruits per plant. However, there were no statistical differences in plant height, total fresh weight of fruits, sugar content, fruit hardness, and vitamin C. Stem thickness was lower in M20, M40, O20, and O40 compared to the control group. The total number of fruits per plant was higher than the control group in only Z40. The inorganic constituents of cherry tomatoes showed statistical significance. After the experiment, the highest sodium content was found in Z40.Conclusion: This study was conducted to provide convenience in soil and crop management by analyzing various factors to find out the effect of companion plants and plant spacing on the growth and fruit quality of cherry tomatoes. As a result, the most effective way to improve growth and quality of cherry tomatoes is to plant them with zinnia within 40 cm of plant spacing.
Effects of Gardening Activities on Parenting Stress and Mental Health of Parents of Children with Developmental Disabilities
Authors: Kang Kyung Im , Yun Suk Young
Published: September 2022

Background and objective: This study was conducted to investigate the psychological and emotional effects of gardening activities held on the campus of D University on parents of children with developmental disabilities.Methods: There were 12 study subjects, including 11 parents of children with developmental disabilities, and 1 grandmother as a primary caregiver. A gardening program was conducted for 30 sessions twice a week over 3 months, from August 21 to November 27, 2021. Gardening activities including gardening practice and plant monitoring were performed in a 'healing garden' on the campus of D University, in a program designed to combine activities on the trail and those in an outdoor garden on the campus. Tests were conducted to verify the effects of such activities, including the Parenting Stress Index (K-PSI-4) and Korean-style mental health assessment (MHA) with 5 types of scales (depression, anxiety, daily vitality, quality of life, and mindfulness).Results: Based on the K-PSI-4 results, the total parenting stress level was decreased from 261.6 points in the pre-test to 241.5 points in the post-test, and notably, the stress level in the Child domain decreased by a significant level, from 120.1 to 109.1 points (p < .05). In the subscale of Acceptability in the Child domain, and the subscale of Isolation in the Parent domain, there were significant changes, from 19.6 to 17.2 points and from 16.2 to 12.6 points, respectively (p < .05). Based on the Korean-style MHA results, there were significant changes in depression, from 3.34 points in the pre-test to 1.24 points in the post-test, and in the daily vitality scale, from 18.25 to 21.38 points (p < .05). In a survey of participants' satisfaction with the program, all participants answered that their daily stress was relieved, which was the most common response given. This was followed by "acquiring knowledge about plants and gardens" and "maintaining physical health."Conclusion: The gardening program had psychological and psychological effects on parents of children with developmental disabilities, including the effects of reducing parenting stress and lowering depression and anxiety. It is expected that gardening programs will play a good role as a support program for persons with disabilities or diseases, as well as for their caregivers and guardians.