bluuebunny/crossref_metadata_2025 huggingface dataset:
Study Case Literature Review Efektivitas Rebusan Daun Sirih Merah Dan Jus Nanas Terhadap Flour Albus Pada Wanita Usiasubur Di Tpmb P Kecamatan Pacet Kabupaten Cianjur
Authors: Aseh Purwanti Budi , Yolandia Rita Ayu , Sugesti Retno
Published: October 2024

Efektivitas Rebusan Daun Sirih Merah Dan Jus Nanas Terhadap Flour Albus Pada Wanita Usia Subur Di Tpmb P Kecamatan Pacet Kab Cianjur. Keputihan merupakan hal yang fisiologis. Jika terjadi pada masa dan menjelang dan sesudah menstruasi. Akan tetapi, jika keputihan tidak ditangani baik, dapat mengakibatkan infeksi kelamin Wanita. Untuk mengetahui Efektivitas Rebusan Daun Sirih Merah Dan Jus Nanas Terhadap Flour Albus Pada Wus Di TPMB P Kecamatan Pacet Kab Cianjur Tahun 2024. Desain penelitian yang akan dipakai dalam riset ini merupakan penelitian kualitatif dengan pendekatan Study Case Literature Review (SCLR) dengan menggunakan 2 responden. pada kasus I yaitu pasien yang diberikan intervensi Rebusan Daun Sirih Merah diketahui hasil pemeriksaan keputihan pada kunjungan ke-1 adalah ada keputihan, kunjungan ke-2 masih keputihan dan pada kunjungan ke-3 keputihan sudah tidak ada. Sedangkan pada kasus II yaitu pasien yang diberikan intervensi jus buah nanas diketahui hasil pemeriksaan pada kunjungan ke-1 mengalami keputihan, kunjungan ke-2 dan kunjungan ke-3 sudah tidak keputihan. Pemberian Jus Nanas lebih efektif dalam penanganan Flour Albus pada Wanita Usia Subur (WUS) dibandingkan dengan pemberian Rebusan Daun Sirih Merah. Hasil penelitian ini diharapkan dapat menjadi bahan kajian dalam meningkatkan promosi  kesehatan tentang pengobatan non farmakologi dan komplementer untuk mengatasi flour albus pada Wanita usia subur (WUS).
Hubungan Umur Kehamilan Dan Paritas Terhadap Kejadian Berat Badan Lahir Rendah (BBLR) Di Rumah Sakit Umum Daerah Pagelaran Kabupaten Cianjur
Authors: Hasan Hasan , Yuliana Triagung , Wissaputri Ema Wulina
Published: October 2024

Bayi dengan Berat Badan Lahir Rendah (BBLR), yakni kurang dari 2.500 gram, merupakan masalah kesehatan yang turut berkontribusi terhadap angka kematian bayi. Untuk Mengetahui Hubungan Umur Kehamilan Dan Paritas Terhadap Kejadian BBLR Di Rumah Sakit Umum Daerah Pagelaran Kabupaten Cianjur Tahun 2024. Jenis penelitian ini adalah analitik observasional. Jenis penelitian yang dilakukan merupakan penelitian analitik observasional karena peneliti akan mencari hubungan antara variabel satu dengan yang lainnya dengan mengobservasi tanpa melakukan perlakuan terhadap variabel. Desain penelitian yang digunakan dalam penelitian ini adalah cross sectional. Ada hubungan antara Umur Kehamilan terhadap Kejadian BBLR dengan p-value 0,000, dan tidak ada hubungan antara paritas dengan kejadian BBLR dengan p-value 0,696. Diharapkan lebih aktif memberikan penyuluhan atau KIE, memasang media poster, serta memberikan leaflet yang berkaitan dengan Gizi pada ibu hamil, sehingga dapat membangkitkan kesadaran dalam menjaga kesehatan ibu dalam memperhatikan Kesehatan ibu dan bayi yang dikandungnya.
Evaluasi Ketidaktepatan Pengisian Kode Diagnosis Utama Pasien Rawat Inap Penyakit Dalam Dan Anak Periode Triwulan Iv 2023 Berdasarkan Icd-10 Di RSUD CILILIN
Authors: Anisa Alya , Monica Rizqy Dimas
Published: October 2024

Berdasarkan studi pendahuluan pada Februari 2023 terdapat 14 dari 25 sampel kode diagnosis utama pasien rawat inap tidak tepat. Ditemukan juga petugas ketidaklengkapan pengisian catatan medis merangkap pekerjaan menjadi petugas kodifikasi. Tujuan penelitian mengetahui evaluasi ketidaktepatan pengisian kode diagnosis utama pasien rawat inap penyakit dalam dan anak berdasarkan ICD-10 di RSUD Cililin. Metode penelitian menggunakan metode deskriptif pendekatan kuantitatif. Populasi sebanyak 1.541 diagnosis utama pasien rawat inap penyakit dalam dan anak triwulan IV 2023. Sampel sebanyak 94 dihitung menggunakan rumus slovin. Pengumpulan data dengan wawancara, observasi, studi kepustakaan dan studi dokumentasi. Instrumen penelitian meliputi alat tulis, lembar checklist, pedoman wawancara dan ICD-10 browser. Hasil penelitian menemukan meskipun terdapat SPO kodifikasi, tetapi masih tingginya angka ketidaktepatan pengisian kode diagnosis utama pasien rawat inap penyakit dalam dan anak periode triwulan IV 2023 di RSUD Cililin khususnya bulan November sebesar 93,33% dengan jumlah sampel yang diambil sebanyak 15 sampel. Penulis menyarankan petugas selalu menjadikan SPO sebagai acuan dalam pemberian kode diagnosis serta memberikan pelatihan terkait kodifikasi diagnosis jika masih belum memungkinkan adanya coder khusus rawat inap.
Hubungan Dukungan Sosial Dengan Kepatuhan ARV Pada Pasien HIV AIDS Di Puskesmas Sukabumi Bandar Lampung
Authors: Aini Fadhilah , Hasbie Neno Fitriyani , Fitriani Dita , Farich Achmad
Published: October 2024

Human Immunodeficiency Virus (HIV) bisa menyebabkan AIDS. Orang yang terkena HIV/AIDS menghadapi lebih banyak tantangan, termasuk dari fisik, psikologis, serta sosial. Dikarenakan semua orang disekitar dia menghindari atau mengucilkan mereka, Masalah psikologis yang mereka hadapi sangat besar. Beberapa atau bahkan sebagian besar masyarakat mengakatan HIV AIDS penyakit yang bisa menular serta berbahaya yang bisa melawati kegiatan sehati-hari, sebagai bersentuhan tangan atau lewat ludah saat sedang berbicara. Studi analitik kuantitatif, desain cross-sectional, dan metode pengambilan sampel total dengan kuesioner digunakan dalam jenis penelitian ini. Analisis hubungan dukungan sosial dengan kepatuhan ARV pada pasien HIV AIDS di Puskesmas Sukabumi menunjukkan bahwa dukungan sosial dapat meningkatkan kepatuhan pasien HIV AIDS terhadap ARV. Terdapat hubungan emosional dengan kepatuhan ARV pada pasien HIV AIDS dengan p = 0.019 (p < 0,05), tidak ada hubungan instrumental dengan kepatuhan ARV pada pasien HIV AIDS dengan p = 0,373 (p > 0,05), dan ada hubungan informatif dengan kepatuhan ARV pada pasien HIV AIDS dengan p = 0,005 (p < 0,05) dan adanya hubungan dukungan persahabatan dengan kepatuhan ARV pada pasien HIV AIDS dengan p = 0,036 (p < 0,05).
Hubungan Supervisi Kepala Ruangan Dan Pengetahuan Pendokumentasian Asuhan Keperawatan Berdasarkan 3S (SDKI, SIKI, SLKI) Dengan Mutu Asuhan Keperawatan Di Ruangan Rawat Inap RSUD Jendral Ahmad Yani Metro Lampung
Authors: Intan Intan Priskila , Wulandari Rizki Yeni , Elasari Yunina , Nugroho Tri Adi
Published: October 2024

Kemampuan Supervisi Kepala Ruangan yang baik berpengaruh terhadap meningkatnya kepatuhan dalam kelengkapan pendokumentasian asuhan keperawatan, pengetahuan perawat tentang pendokumentasi asuhan keperawatan berdasarkan 3S serta dapat meningkatkan mutu asuhan keperawatan dan kualitas pelayanan kesehatan. Sedangkan Di RSUD Jend Ahmad Yani Metro kepala ruangan perlu melakukan supervisi yang lebih optimal untuk meningkatkan kualitas dokumentasi asuhan keperawatan dan beberapa perawat belum paham pendokumentasi asuhan keperawatan. Tujuan penelitian ini diketahui hubungan supervisi ruangan dan pengetahuan pendokumentasian asuhan keperawatan berdasarkan 3S (SDKI, SIKI, SLKI). Jenis penelitian ini adalah kuantitatif, dengan desain penelitian deskriptif kolerasional menggunakan penedekatan cross sectional. Populasi adalah seluruh perawat rawat inap RSUD Jend Ahmad Yani Metro sebanyak 164 perawat. Dalam penelitian ini sampel yang digunakan sebanyak 116 perawat dengan teknik purposive sampling. Analisa data menggunakan uji gamma. Hasil penelitian menunjukan ada hubungan supervisi kepala ruangan dengan mutu asuhan keperawatan di ruangan rawat inap RSUD Jend Ahmad Yani Metro diperoleh P-value 0,000 (<0.05), dan pengetahuan pendokumentasi berdasarkan 3S dengan mutu asuhan keperawatan di ruangan rawat inap RSUD Jend Ahmad Yani Metro diperoleh P-value 0,000 (<0.05). Hasil penelitian diharapkan dapat menjadikan sebuah masukan bagi RSUD Jend Ahmad Yani Metro untuk memberikan kebijakan melakukan pelatihan untuk meningkatkan pengetahuan dan keterampilan bagi supervisi kepala ruangan serta perawat dalam melakukan pendokumentasian asuhan keperawatan di setiap ruangan.
Formulation of Nutraceutical Jelly Candy from a Combination of Cucurbita moschata Puree and Averrhoa carambola Juice as Antioxidant
Authors: Soraya Alya Fajrina , Kawareng Andi Tenri , Agustina Risna
Published: October 2024

Nutraceutical candy jellies are gaining popularity as a potential approach to deliver antioxidants in a palatable form. This study investigated the antioxidant activity of Cucurbita moschata puree combined with Averrhoa carambola juice, formulated into jelly candies. Design-Expert software V.13 was used to optimize the jelly candy base formula. The combined C. moschata puree and A. carambola juice exhibited strong antioxidant activity (IC50 = 29.580 ppm) at variation V1. The optimal base formula B3 consisted of 12% gelatin and 4% carrageenan. The formulated jelly candy possessed very strong antioxidant activity (IC50 = 44.771 ppm). These findings suggest the potential of C. moschata puree and A. carambola juice as ingredients in functional jelly candies.
Peran Kader Posyandu Usaha Bersama I Dalam Pencegahan Stunting di Kelurahan Hilir Sper Kabupaten Barito Selatan
Authors: Cilatesni Cilatesni , Wahidin Wahidin , Darlan Saifullah
Published: October 2024

Penelitian ini bertujuan untuk mendeskripsikan menegenai peran kader posyandu usaha bersama I dalam pencegahan stunting di Kelurahan Hilir Sper Babupaten Barito Selatan. Penelitian ini menggunakan metode kualitatif dengan teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Adapun yang menjadi Informan penelitian terdiri ibu-ibu kader Posyandu, bidan, Lurah Hilir Sper dan orang tua balita. Analisis data dilakukan secara bersamaan, mulai pengumpulan data, kondensasi data, display data, dan verifikasi dan kesimpulan. Begitu pula dalam pemeriksaan keabsahan data dilakukan melalui triangulasi, ketekunan pengamatan dan member check. Hasil penelitian bahwa kader Posyandu Usaha Bersama I berusaha secara maksimal dalam membantu pencegahan adanya gejala stunting pada anak usia balita di kelurahan Hilir Sper Kabupaten Barito Selatan. Keberhasilan dalam mencegah gejala stunting pada balita ini tidak terlepas dari peran kader Posyandu secara rutin melakukan kunjungan kerumah-rumah ibu hamil dan anak balita yang bergejala stunting.
Tax Service Quality, Trust in Government and Tax Compliance among Small and Medium Enterprises in North Rift Economic Bloc
Authors: Kiptum Amos , Kapkiyai Collins , Kirui Daniel
Published: October 2024

Purpose- The study sought to establish the indirect effect of trust in government on the relationship between the tax service quality and tax compliance among SMEs in North Rift Economic Bloc, Kenya.Design/Methodology- Based on the social contract theory, this study has a positivist philosophy that is informed by an explanatory research design. The target population was 21,232 SMEs; the sample size used in this study consisted of 393 SME owners/managers selected through a stratified sampling technique. Data were collected using a self-administered questionnaire, and Cronbach's alpha with factor analysis was used to establish the instrument's reliability and validity. Descriptive and inferential statistics were employed to test the hypothesis, and hierarchical regression using the Hayes Process macro was performed.Findings-The study revealed that tax service quality (β =.541, p=.000<0.05) and trust in government (β =.375, p=.000<0.05) are significantly positively related to tax compliance. In addition, the tax service quality was found to have a significant effect on trust in government (β =.395, p =.000<0.05). In addition, the results showed that trust in government mediates the relationship between tax service quality and tax compliance (β =.1482, CI=.0981, .2015).Practical Implications- These findings underscore the need for governments to improve the quality tax services, as this may be able to help in gaining public trust which will ultimately increase SMEs compliance with taxes. There is scope for future research to incorporate mixed-method approaches in order to discover yet more factors affecting tax compliance.
LITERATURE REVIEW: POTENSI SELADA AIR SEBAGAI ANTIOKSIDAN DAN ANTIKANKER
Authors: Claresta Fariqzah
Published: October 2024

Tanaman selada air (Nasturtium officinale R. Br.) merupakan tumbuhan yang menarik untuk dipelajari. Tumbuhan ini berasal dari Eropa dan Asia, dan sering dikonsumsi sebagai sayuran atau dalam salad karena kandungan nutrisinya yang kaya. Selada air juga dapat ditemukan di dataran tinggi Indonesia. Tanaman ini merupakan contoh tanaman hidroponik yang tumbuh tanpa media tanah, dan pertumbuhannya dipengaruhi oleh nutrisi, tingkat keasaman, dan suhu media air. Variasi lingkungan tempat tumbuh juga mempengaruhi kandungan senyawa kimia yang dihasilkan oleh tanaman selada air. Adanya kandungan kimia seperti flavonoid, alkaloid, saponin, triterpenoid dan steroid yang dapat ditemukan dengan uji fitokimia. Ekstrak selada air menunjukkan aktivitas antioksidan dan kandungan flavonoid yang tinggi. Proses ekstraksi dilakukan untuk mengoptimalkan kandungan saponin sebagai antioksidan. Penelitian juga menunjukkan bahwa selada air mengandung senyawa seperti phenethyl isothiocyanate, isotiosianat, kaemferol glikosida, dan l-triptofan yang memiliki potensi sebagai agen antikanker. Selada air juga dapat digunakan untuk mengobati tuberkulosis dan diabetes. Sehingga hasil penelitian menyimpulkan bahwa selada air mengandung berbagai metabolit sekunder seperti flavonoid, fenolik, alkaloid, saponin, triterpenoid, dan steroid, serta menunjukkan aktivitas antioksidan dan antikanker dengan IC50 yang cukup tinggi. Aktivitas antioksidan selada air tergolong sedang hingga tinggi, mendukung potensinya sebagai tanaman antikanker. Aktivitas antioksidan selada air bahkan lebih tinggi daripada Vitamin C. Dengan mengandung metabolit sekunder ini, selada air dapat dijadikan sebagai bahan farmasi dalam pengobatan.
Kata Kunci : selada air, antioksidan, antikanker
DEVELOPMENT OF HIGHLY PATHOGENIC AVIAN INFLUENZA VACCINE FOR PANDEMIC INFLUENZA PREPAREDNESS: A REVIEW
Authors: S,Si, M.Biomed Debie Rizqoh
Published: October 2024

The Highly Pathogenic Avian Influenza (HPAI) H5N1 virus caused extraordinary incidents in several countries, especially Asia, Africa, and Europe. The disease's fatality rate caused by the H5N1 virus reaches 60%. This incident raised concerns about a wider HPAI H5N1 virus pandemic if effective human-to-human transmission occurred. Therefore, the World Health Organization (WHO) calls on all countries to prepare themselves for a pandemic that may occur. One of the strategies in preparation for this pandemic is to develop a vaccine. So far, vaccines are effective in disease prevention efforts because they can work to trigger a natural immune response and induce a memory response against the pathogen in question. Several strategies are needed to develop an effective influenza vaccine in carrying out vaccine development research and in-depth understanding of (i) virology, (ii) virus life cycle, (iii) host immune response to infection, (iv) pathology, and (v) HPAI H5N1 vaccine development strategy. Until now, many HPAI H5N1 vaccines have been developed, from vaccines developed using conventional methods to alternative vaccines using more modern methods. The results of the development of the vaccine are expected to provide provisions for a possible pandemic caused by the HPAI H5N1 virus.
Keywords : Influenza, virus, vaccine
Syringocystadenoma Papilliferum in the Medial Canthus of an Eyelid
Authors: Lee Ji Heon , Park Young Min , Jang Mi , Kim Hye Young
Published: October 2024

Purpose: To report a rare case of syringocystadenoma papilliferum occurring in the medial canthal area.Case summary: A 74-year-old female presented with a growing mass on the nasal side of the right eye for the past 3 months. The mass, measuring approximately 5.0 mm in central diameter, was located on the inner aspect of the right eyelid and was ulcerated. An excisional biopsy was performed, and the histopathological examination revealed a lesion characterized by exophytic squamous epithelial hyperplasia with central invagination forming a crater-like structure. The lesion had a bilayer configuration, with cuboidal basal cells in the periphery and columnar luminal cells on the inside. These findings were consistent with the diagnosis of syringocystadenoma papilliferum.Conclusions: Syringocystadenoma papilliferum was diagnosed in an eyelid mass, emphasizing the need to consider this condition in the differential diagnosis of eyelid masses given the diverse clinical manifestations associated with syringocystadenoma papilliferum.
SCIENTIFIC SCHOOL «PRIVATE LAW PROVISION OF RELATIONS IN THE PENAL SYSTEM»: THE HISTORY OF THE FORMATION AND PROSPECTS FOR THE DEVELOPMENT
Authors: Blinkov Oleg
Published: October 2024

The article analyzes the history of the formation and development of the scientific school of private law support for the activities of the penal system. The historical background of its origin is revealed, the main activities of the scientific school and its scientific results, their practical use are characterized. The author defines the prospects for the research of the scientific school, including in the field of cooperation with domestic and foreign organizations.
ENSURING FOOD SECURITY THROUGH THE DEVELOPMENT OF EXPORT SUPPLIES OF BUCKWHEAT AND ITS PROCESSED PRODUCTS
Authors: Rakhmatullin Ramil
Published: October 2024

The article presents the results of a study of food security processes based on the development of export supplies of buckwheat and its processed products. The characteristics of buckwheat and rice in terms of the content of nutrients, vitamins and trace elements were compared. An infographic of the distribution of global buckwheat production by country is presented. A study was conducted on the possibilities of producing products of deep processing of buckwheat and the export potential of these goods. Promising directions for improving food security in the field under study are outlined.
Manufacturing and Characterization of Polypropylene-Paper Composites for Automotive Applications
Authors: Grubb Cecile A. , Kardos Marton , Webb Christopher D. , Mainka Hendrik , Keffer David J. , Harper David P.
Published: October 2024

The automotive industry is under significant pressure to curb greenhouse gas emissions from their products as the negative impacts on the environment are increasingly apparent. As such, there is significant interest within the industry to develop low-carbon footprint materials. Natural fiber composites are therefore appealing due to both their decreased carbon footprint, as well as their relatively low cost, low density, and beneficial acoustic properties. This research specifically focuses on the use of paper fibers as composite reinforcements. Paper offers additional benefits over other natural fiber types in that it is globally available, does not compete with food resources, and has well-established quality control techniques. The goal of this work was to study the manufacturing of polypropylene (PP)-paper fiber composites using a hybrid wet-lay/compression molding processing. The processing parameters studied included molding temperature, molding duration, and molding pressure. Paper composites were characterized for properties including flexural strength, impact strength, and water uptake rate. An optimal set of processing parameters was identified in which cycle time and energy inputs (e.g. temperature and pressure) were minimized while retaining desired material properties.
Manufacturing of Thermoset Polyimide Composites by Laser Sintering
Authors: Chuang Kathy C. , Spade Will , Gillham Justin , Gornet Timothy J. , Schneidau Kate , Koerner Hilmar
Published: October 2024

Selective Laser Sintering (SLS) is an additive manufacturing technique that builds 3D models layer by layer using a laser to selectively melt cross sections in powdered polymeric materials, following sequential slices of the computer-aided design (CAD) model. SLS generally uses thermoplastic polymeric powders such as polyamides. The resultant 3D-printed objects are often weaker in their strength compared to traditionally processed materials, due to their higher porosity. This paper described the process development of using melt-processable imide oligomers terminated with reactive 4-phenylethynylphthalic anhydride (4-PEPA) to conduct laser sintering (LS). The first successful 3D-printing of high temperature RTM370 thermoset polyimide carbon fiber composite was further post-cured to promote additional crosslinking for achieving higher temperature (Tg = 370°C) capability. Another novel imide oligomer, RTM385-SLS, formulated with a complex melt viscosity [h*] of ~104-105 poise is also suitable for LS. RTM385-SLS resin powder was mixed with 20-25% of hexagonal boron nitride (h-BN) and subjected to LS to print out “Green” specimens which could be further post-cured to afford a thermally conductive but electrically insulating composites with high Tg of 385°C. The cured composite specimens were then subjected to mechanical testing, thermal conductivity and porosity evaluation as well as SEM characterization.
Honeycomb Molding - Forming Thermoplastic Sandwich Structures for Interior Applications
Authors: Wist Santino , Gries Thomas
Published: October 2024

Trains play an important role in the sustainable mobility of the future. The changes in the market are reflected in the number of newly approved series by the German Federal Railway Authority (EBA); 226 new designs and redesigns of train cars were approved for use on German rails in 2019. Phenol-formaldehyde resins are used extensively specifically for railcar interiors. However, phenol-formaldehyde resins release carcinogenic vapors during and even after production if not completely sealed. As a result, European production standards and requirements have been increased, making the material less economical and increasingly difficult to enter the market. Further bans aimed at lower formaldehyde release limits are currently being considered by the European Union's Committee for Risk Assessment (RAC) and Committee for Socioeconomic Analysis (SEAC). In order to develop and design alternative materials, it is important to meet the requirements for stiffness, light weight, insulation and sustainability simultaneously. This research aim is therefore to develop a new class of material for interior components with improved stiffness, lower weight, lower CO2 footprint and no health hazards. The approach is to develop advanced composite sandwich panels that retain the ability to be molded into complex structures for interior applications. This is done through a thermoplastic honeycomb core structure that is manufactured directly from sheet material and fiber reinforced organo-sheets as the outer layers. The base matrix for all layers is kept uniform for better recyclability and consists of polycarbonate (PC) with sufficient flame retardant properties to provide an environmentally friendly alternative to existing phenolic resin and aramid epoxy honeycomb solutions while still complying with the security norms.
Ultra-high-rate Manufacturing of Thermoplastic Window Plug using Hybrid Overmolding
Authors: Seneviratne Waruna P. , Teoh Jerome , Herath Induwara , Schubert Eugen
Published: October 2024

Highly loaded complex parts are machined from a solid block of metal by removing material through cutting, boring, drilling, and grinding to obtain the three-dimensional shape. Most cases, this involves removing as much as 80 percent of the material from a billet, which is time-consuming and inefficient considering the cost of the materials. Alternatively, these complex parts can be manufactured using hybrid overmolding process which involves injecting plastics over a reinforced substrate with continuous fiber-reinforcement eliminating subtractive machining or joining of multiple parts. The substrate is typically heated using an infrared (IR) oven and preformed over a solid mold to a three-dimensional shape using thermoforming. Injection overmolding material can also be reinforced with discontinuous fibers based on the design requirements. Both thermoforming and injection molding are matured automotive ultra-high-rate manufacturing processes. Adopting these technologies to aerospace requires advanced aerospace-grade thermoplastic material systems and developing the hybrid overmolding process that combines both thermoforming and injection molding processes. Material compatibility is one of the key enablers for the fusion across the overmolded interfaces. To demonstrate the overmolding technology for an aerospace application, Victrex AE250 low-melt polyaryletherketone (LM-PAEK) system reinforced with AS4 fibers and a 30% carbon fiber-reinforced polyetheretherketone (PEEK) were used to overmold aircraft window plugs to be used for cargo conversion of passenger aircraft. The fully automated overmolding process was demonstrated using KraussMaffei multi-robotic thermoforming and injection molding system. Thermal and mechanical test evaluations were employed to assess the material compatibility and overall part quality. Photomicrographs and flexure tests conducted on test samples extracted from the window plugs indicated satisfactory fusion across the overmolded interface and optimized holding of PEEK materials.
The seven-dimensional universe
Authors: Kesanasetty Sasidhar
Published: October 2024

This paper elucidates the concept of dark energy and the acceleration of the universe through the quantization of space in hidden dimensions, which provides the foundation for gravitational force. Space-time is conceptualized as a four-dimensional elastic grid within a seven-dimensional universe, wherein matter expands concurrently with the universe. Each cube of the grid is considered a quantum of hidden three-dimensional space of Planck volume containing Planck charge, rendering the universe seven-dimensional. The phenomenon of dark energy is attributed to the electrostatic repulsion between Planck charges in each quantum of the hidden space, and the corresponding energy density is correlated with the Hubble parameter H(z), which accounts for the accelerated expansion of the universe and the increase in the relative cosmological potential energy/rest mass of matter. The expansion of space-time is posited to result not from the creation of new space but from the stretching of existing space-time, analogous to an elastic ruler where proper length and volume remain constant. The relative values of the Planck constant, gravitational constant, permittivity of free space, and Boltzmann constant are demonstrated to vary due to the expansion or contraction of space in cosmological and gravitational frameworks, but are compensated for by the proportional change in the relative rest mass. This theory also establishes a framework for the relativistic Newtonian theory of gravity, the respective MONDian (Modified Newtonian dynamics) gravity, identifies a rationale for the transition of Newtonian gravity to MOND at a0, and elucidates the dynamics of galaxy clusters without invoking dark matter.
A remark on the Riemann zeta function
Authors: Abe Yukitaka
Published: October 2024

We prove that if the number of nontrivial zeros of the Riemann zeta function which are not on the critical line is finite, then every nontrivial zeros is on the critical line.
A case report of severe pulmonary legionellosis caused by Legionella bozemanae
Authors: Xu Peixing , Wang Fang , Ren Hongyu , Ni Wentao , Zhao Na , Li Ran , Chen Yanwen , Gao Zhancheng , Qin Tian
Published: October 2024

We report a case of Legionnaires’ disease caused by Legionella bozemanae, which is the first time that L. bozemanae has been isolated from a bronchoalveolar lavage fluid sample from an immunocompromised patient in China. The findings highlight the susceptibility of immunocompromised patients to infections caused by the rare but highly pathogenic L. bozemanae.
Synthesis and antibacterial potential of novel thymol derivatives against methicillin-resistant Staphylococcus aureus and P. aeruginosa pathogenic bacteria
Authors: Shahi Ashutosh , Manhas Rakshit , Bhattacharya Srija , Rathore Arti , Kumar Puneet , Samanta Jayanta , Sharma Manish Kumar , Mahapa Avisek , Gupta Prasoon , Anal Jasha Momo H.
Published: October 2024

The increasing threat of antibiotic resistance has created an urgent need for new antibacterial agents, particularly plant-based natural compounds and their derivatives. Thymol, a natural monoterpenoid phenolic compound derived from Monarda citriodora, is known for its aromatic and therapeutic properties, including antibacterial activity. This study focuses on synthesizing dihydropyrimidinone and dihydropyridine derivatives of thymol and exploring their antibacterial properties. The synthesized compounds were tested for their in vitro antibacterial potential against pathogenic microorganisms, specifically Pseudomonas aeruginosa (Gram-negative) and methicillin-resistant Staphylococcus aureus (MRSA) (Gram-positive). Among the synthesized derivatives, compound 3i (ethyl 4-(4-hydroxy-5-isopropyl-2-methylphenyl)-2-imino-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate) exhibited the most promising antibacterial activity, with minimum inhibitory concentration (MIC) values of 12.5 µM against P. aeruginosa and 50.0 µM against MRSA. Additionally, compound 3i demonstrated a synergistic effect when combined with vancomycin, enhancing its antibacterial efficacy. The optimum fractional inhibitory concentration index (FICI) observed was 0.10 and 0.5 for MRSA and P. aeruginosa, respectively, in combination with vancomycin. In silico analysis of the physiochemical properties of 3i indicated compliance with all drug-likeness rules. Furthermore, molecular docking studies revealed that compound 3i has a stronger binding affinity to the target protein than thymol, providing valuable insights into its potential mechanism of action.
The incremental value of interatrial septum motion in predicting thrombus or spontaneous echo contrast in patients with non-valvular atrial fibrillation: an observational study on transesophageal echocardiography
Authors: Zeng Decai , Chang Shuai , Zhang Xiaofeng , Zhong Yanfeng , Yongzhi Cai , Huang Tongtong , Wu Ji
Published: October 2024

Background

The thickness and motion of the Interatrial Septum (IAS) possibly serves as indicators of both structural and functional remodeling of left atrium. This study aims to use transesophageal echocardiography (TEE) to assess IAS motion in non-valvular atrial fibrillation (NVAF) and investigate its correlation with the risk of spontaneous echo contrast (SEC) and thrombus (TH).

Methods

We conducted a cross-sectional study on 318 patients with NVAF who underwent transthoracic echocardiography and TEE. IAS motion was defined as the maximum displacement of IAS observed throughout the cardiac cycles using M-mode TEE.

Results

The prevalence of SEC/TH was 39.9% (127/318) in the overall group. In paroxysmal atrial fibrillation (PAF), the prevalence rate of SEC/TH was 25.3% (47/186), compared to 60.6% (80/132) in persistent atrial fibrillation (PeAF). Multivariable analyses showed that LA volume index (LAVI), mean E/e’, S/D ratio, IAS motion and CHA2DS2-VASc scores were significantly associated with SEC/TH. Patients with lower IAS motion showed a higher prevalence of SEC/TH compared to those with higher IAS motion (71.3% vs. 11.6%; P < 0.001). The IAS motion under sinus rhythm could better predict risk of SEC/TH, while the predictive efficacy under AF rhythm was slightly attenuated but still had a high AUC value (0.779). A significant positive correlation was observed between the IAS motion and the LAA filling velocity (PAF r = 0.47; P<0.001 and PeAF r = 0.38; P < 0.001, respectively), LAA emptying velocity (PAF r = 0.55; P < 0.001 and PeAF r = 0.47; P < 0.001, respectively) and LAVI (PAF r = 0.59; P < 0.001 and PeAF r = 0.44; P < 0.001, respectively). The integration of the IAS motion to the CHA2DS2-VASc, LAVI and mean E/e’ provided important incremental predictive value of SEC/TH (AUC = 0.859 vs. 0.826, P = 0.02).

Conclusion

IAS motion measured by TEE correlates well with LAA flow velocity and LA size and is independently associated with SEC/TH in NVAF. Additionally, lower IAS motion is associated with a higher prevalence of SEC/TH. Furthermore, the integration of IAS motion to CHA2DS2-VASc, LAVI and mean E/e’ can provide additional value for the prediction of SEC/TH.
Metabolic obesity phenotypes and the risk of cancer: a prospective study of the Kailuan cohort
Authors: Zheng Xin , Wang Yiming , Chen Yue , Liu Tong , Liu Chenan , Lin Shiqi , Xie Hailun , Ma Xiangming , Wang Ziwen , Shi Jinyu , Zhang Heyang , Yang Ming , Liu Xiaoyue , Deng Li , Zhang Qingsong , Shi Hanping
Published: October 2024

Background

Obesity is as an important risk factor for chronic diseases. Metabolically healthy obesity (MHO) is considered a benign state. The association between metabolic health and obesity categories and cancer risk remains unclear. This study aimed to investigate the relationship between metabolic health status combined with obesity phenotypes and the risk of cancer.

Methods

Data from 91,834 participants in the Kailuan cohort were analyzed, excluding individuals with a body mass index (BMI) < 18.5 kg/m² and those with a history of cancer. Obesity phenotypes were classified based on BMI and waist circumference (WC) combined with metabolic health status, resulting in six phenotypes. Cox proportional hazard regression models were used to assess the association between metabolic health and obesity phenotypes with cancer risk and all-cause mortality.

Results

The prevalence of metabolically healthy obesity and metabolically unhealthy obesity defined by BMI was 6.86% and 12.18%, while that defined by WC was 20.79% and 25.76%, respectively. Compared to metabolically healthy participants, individuals with an unhealthy metabolic status had a significantly higher risk of cancer (HR, 1.09; 95% CI, 1.03–1.15; p=0.004). The hazard ratios for cancer were 1.19, 1.23, 1.20, and 1.55 for individuals with one, two, three, and four metabolic disorders, respectively. Among those classified as metabolically unhealthy, both overweight and obesity were associated with a protective effect on cancer risk (HR, 0.88; 95% CI, 0.80–0.96; p=0.006 for overweight; HR, 0.87; 95% CI, 0.78–0.97; p=0.010 for obesity). However, abdominal obesity significantly increased cancer risk in both metabolically healthy and unhealthy participants. In subgroup analysis, simple obesity showed a protective trend against cancer in those with respiratory cancers, while abdominal obesity consistently posed a risk for various cancer types.

Conclusion

Metabolically unhealthy status and abdominal obesity are risk factors for cancer and all-cause mortality, whereas simple obesity offers protective effects against cancer and all-cause mortality in metabolically unhealthy individuals. These findings suggest that maintaining metabolic health and reducing the metabolic risks associated with abdominal obesity should be key targets for cancer prevention.
A study of short-term wind power segmentation forecasting method considering weather on ramp segments
Authors: Yang Chunxiang , Wu Guodong , Zhang Yongrui , Bao Guangqing , Wang Jianhui
Published: October 2024

The short-term fluctuation of wind power can affect its prediction accuracy. Thus, a short-term segmentation prediction method of wind power based on ramp segment division is proposed. A time-series trend extraction method based on moving average iteration is proposed on the full-time period to analyze the real-time change characteristics of power time-series initially; secondly, a ramp segment extraction method based on its definition and identification technique is proposed based on the results of the trend extraction; and a segmentation prediction scheme is proposed to lean the power prediction under different time-series: the LightGBM-LSTM is proposed for the non-ramping segment using point prediction, and the CNN-BiGRU-KDE is proposed for probabilistic prediction of ramp segments. From the results, this ramp segment definition and identification technique can effectively identify the ramp process of wind power, which makes up for the misidentification and omission of the classical climbing event definition; meanwhile, the segment prediction scheme not only meets the prediction accuracy requirements of the non-ramping segment, but also provides the effective robust information for the prediction of the ramping period, which offers reliable reference information for the actual wind farms. In particular, it is well adapted to wind power prediction under extreme working conditions caused by ramping weather, which is a useful addition to short-term wind power prediction research.
Role of mesoscale eddies in the biogeochemistry of the Mozambique Channel
Authors: Chenillat Fanny , Deshaies Eloise , Arens Aline , Penven Pierrick
Published: October 2024

This study aims to characterize how eddies shape the biogeochemistry of the Mozambique Channel using a physical-biogeochemical model that realistically simulates its interannual dynamics. The 20-year-long numerical simulation provides a comprehensive dataset for robust statistical analysis of thousands of mesoscale features using an eddy detection method. We show that all eddy types significantly shape the biogeochemical landscape over the Mozambique Channel, with varying effects across different areas: (1) Sofala Bank and Delagoa Bay: Cyclonic eddies enhance diatom production. (2) Comoros Basin: Cyclonic eddies favor diatom growth via nutrient-rich waters from the NEMC. (3) Central Mozambique Channel: Anticyclonic eddies and rings promote nanophytoplankton through eddy-topography interactions. (4) Southern Mozambique Channel: A mix of eddies from the MC and South Madagascar influences diverse responses due to coastal upwelling. This diversity of processes results in distinct biological signatures of eddy types, leading to diverse ecosystem assemblages with a clear oligotrophic signature.
Skerki Bank (Strait of Sicily) is a hotspot of molluscan biodiversity: multiple new records for Tunisian waters and description of three new species
Authors: Antit Mouna , Gofas Serge , Taviani Marco
Published: October 2024

Sea bottom sampling of the Skerki Bank in the Strait of Sicily updates the census of marine molluscs inhabiting a biogeographically key sector of the Mediterranean Basin. One single dredge haul at 112-m depth yielded 110 molluscan species belonging to Gastropoda, Bivalvia, and Scaphopoda, of which 41 are new records for Tunisian jurisdictional waters, including three gastropod species new to science. Nearly all the species are shared with the fauna inhabiting the adjacent Italian waters, and most of them are reported also from Malta. We stress that sites characterized by a relevant species richness, diagnosed by hosting more than 100 species, inclusive of rare taxa, are important areas for conservation in need of adequate management.
Objectively measured levels of moderate to vigorous intensity physical activity are associated with cognitive impairment in diabetic hemodialysis patients: a cross-sectional study
Authors: Zhang Zhixin , Chen Xiaoyu , Gaowa Siqin , Liang Ruiting , Jin Zhetong , Shi Ziyi , Han Peipei , Lin Cheng , Wen Xiaoli , Lin Peng , Guo Qi
Published: October 2024

Objective

The purpose of this study was to observe the relationship between objectively measured levels of physical activity and cognitive impairment (CI) in the presence or absence of diabetes in middle-aged and elderly hemodialysis patients.

Methods

In this multicenter cross-sectional study, 339 clinically stable hemodialysis patients (210 males; mean age: 67.38 ± 8.07 years) aged ≥55 years were included from 7 dialysis units in Shanghai, China. The Chinese version of the Modified Mini-Mental State Examination (MMSE) was used to assess the CI. The duration of physical activity at different intensities, including moderate to vigorous physical activity (MVPA) as well as light physical activity (LPA), was measured using a triaxial accelerometer (ActiGraph GT3X+, Pensacola, FL, USA). Logistic regression and multiple linear regression were used for analyses.

Results

The prevalence of CI was higher in hemodialysis patients with comorbid diabetes (24.3%). In diabetic patients, MVPA (increase per 10 min/day) was negatively associated with CI after adjusting for covariates [(OR = 0.89, 95%CI = 0.79–0.99), p = 0.042]. However, no significant association between physical activity and CI was found in non-diabetic hemodialysis patients. Further analyses revealed that MVPA was positively associated with temporal orientation, attention and calculation and recall in diabetic hemodialysis patients.

Conclusion

Physical activity was associated with CI in diabetic hemodialysis patients rather than the non-diabetes group. This study is important for early differential diagnosis of CI and improvement of cognitive status in hemodialysis patients.
Identification of key genes and diagnostic model associated with circadian rhythms and Parkinson’s disease by bioinformatics analysis
Authors: Zhang Jiyuan , Ma Xiaopeng , Li Zhiguang , Liu Hu , Tian Mei , Wen Ya , Wang Shan , Wang Liang
Published: October 2024

Background

Circadian rhythm disruption is typical in Parkinson’s disease (PD) early stage, and it plays an important role in the prognosis of the treatment effect in the advanced stage of PD. There is growing evidence that circadian rhythm genes can influence development of PD. Therefore, this study explored specific regulatory mechanism of circadian genes (C-genes) in PD through bioinformatic approaches.

Methods

Differentially expressed genes (DEGs) between PD and control samples were identified from GSE22491 using differential expression analysis. The key model showing the highest correlation with PD was derived through WGCNA analysis. Then, DEGs, 1,288 C-genes and genes in key module were overlapped for yielding differentially expressed C-genes (DECGs), and they were analyzed for LASSO and SVM-RFE for yielding critical genes. Meanwhile, from GSE22491 and GSE100054, receiver operating characteristic (ROC) was implemented on critical genes to identify biomarkers, and Gene Set Enrichment Analysis (GSEA) was applied for the purpose of exploring pathways involved in biomarkers. Eventually, immune infiltrative analysis was applied for understanding effect of biomarkers on immune microenvironment, and therapeutic drugs which could affect biomarkers expressions were also predicted. Finally, we verified the expression of the genes by q-PCR.

Results

Totally 634 DEGs were yielded between PD and control samples, and MEgreen module had the highest correlation with PD, thus it was defined as key model. Four critical genes (AK3, RTN3, CYP4F2, and LEPR) were identified after performing LASSO and SVM-RFE on 18 DECGs. Through ROC analysis, AK3, RTN3, and LEPR were identified as biomarkers due to their excellent ability to distinguish PD from control samples. Besides, biomarkers were associated with Parkinson’s disease and other functional pathways.

Conclusion

Through bioinformatic analysis, the circadian rhythm related biomarkers were identified (AK3, RTN3 and LEPR) in PD, contributing to studies related to PD treatment.
Case report: Asymmetric bilateral deep brain stimulation for the treatment of pantothenate kinase-associated neurodegeneration in a patient: a unique case of atypical PKAN with a novel heterozygous PANK2 mutation
Authors: Hong Guo , Zhang Zhongwen , Wang Peiyi , Li Guoyang , Zhang Wenli , Zou Huahui , Luo Xiaoguang
Published: October 2024

Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive hereditary neurodegenerative disorder, usually caused by mutations in the pantothenate kinase 2 (PANK2) gene. We report a young female patient with atypical PKAN, harboring a novel heterozygous PANK2 mutation, diagnosed through clinical imaging and genetic analysis. The patient presented with dystonia and motor dysfunction after onset, but early brain MRI showed normal findings. Due to progressive symptom deterioration, her MRI was reevaluated and the characteristic “eye of the tiger” sign was identified. Further genetic testing revealed that she was a carrier of two heterozygous PANK2 mutations, one being a known pathogenic variant and the other unknown. Given the patient’s clinical presentation, progressive symptoms, and poor response to medication, we boldly attempted asymmetric bilateral deep brain stimulation (abDBS). Postoperative outcomes showed significant symptom improvement. This study suggests that early brain MRI in PKAN patients may not exhibit typical radiological features, leading to potential diagnostic omissions. Furthermore, it highlights the potential therapeutic effect of abDBS in atypical PKAN, particularly in patients with novel heterozygous PANK2 mutations. Asymmetric bilateral deep brain stimulation may represent a promising treatment approach.
Cinobufotalin inhibits proliferation, migration and invasion in hepatocellular carcinoma by triggering NOX4/NLRP3/GSDMD-dependent pyroptosis
Authors: Liu Chen , Wu Jianmin , Li Zhiwen , Huang Xuanyu , Xie Xianhe , Huang Yun
Published: October 2024

Introduction

Pyroptosis is an inflammatory form of programmed cell death that plays a significant role in tumorigenesis. Cinobufotalin (CB), a bufadienolide extracted from toad venom, is associated with antitumor effects in various cancers, including liver cancer. However, the role of CB in pyroptosis and its underlying mechanisms have not been well characterized.

Methods

MTT, Colony formation, EdU, Wound healing and Transwell migration and invasion assays were applied to determine the effects of CB on the proliferation, migration, and invasion ability of hepatocellular carcinoma (HCC) cells in vitro. The subcutaneous xenograft mouse model and pulmonary metastasis model were used to evaluate the effect of CB on HCC cells in vivo. PCR, western blot, immunohistochemistry, immunofluorescence, and ELISA were used to verify the expression of proliferation, migration, pyroptosis, and inflammation related molecules after CB treatment. Using si-RNA and inhibitors to interfere with NOX4 and HLRP3 expression to validate the key signaling pathways of pyroptosis induced by CB treatment.

Results

In vivo experiments using nude mice with xenografted HCC cells and in vitro experiments with HCC cell lines demonstrated that CB treatment significantly inhibited the proliferation, migration, and invasiveness of HCC cells. CB treatment also showed dose-dependent activation of the NLRP3 inflammasome complex in HCC cells, leading to gasdermin D-induced pyroptosis. However, these effects were abrogated via the pretreatment of HCC cells with VX-765, a caspase-1 inhibitor. Additionally, CB increased the production of reactive oxygen species (ROS) and H₂O₂, along with upregulating NOX4 protein expression in HCC cells. Conversely, NOX4 silencing or pretreatment with VAS2870 (an NOX4 inhibitor) or NAC (an ROS scavenger) suppressed the activation of the NLRP3 inflammasome complex and pyroptosis in CB-treated HCC cells.

Discussion

Our study demonstrated that CB suppressed the proliferation, migration, and invasiveness of HCC cells by inducing pyroptosis through the activation of the NOX4/NLRP3/GSDMD signaling pathway. Therefore, our results suggest that CB is a promising therapeutic agent for HCC.
Noise suppression of infrared thermal imaging of rocket exhaust plume using SPOD
Authors: Fu Debin , Sun Ao , Niu Qinglin
Published: October 2024

The environmental noise have a negative influence on the quality of infrared thermal imaging of the rocket exhaust plume. In this study, the noise data of the unsteady rocket exhaust plume flow field was simulated using Gaussian white noise, and the infrared thermal image of the plume was numerically calculated using the narrow band method (SNB) and the line of sight (LOS) method. The denoising of infrared thermal imaging was achieved through the spectral proper orthogonal decomposition (SPOD) inversion method. Results indicate that Gaussian white noise leads to larger infrared thermal image residuals in the intrinsic core of the plume compared to the mixed regions. The infrared thermal image in the 2.7 μm band is greatly affected by the noise with an average error of 21.1%, and the average error in the 4.3 μm band is 17.6%. After SPOD denoising, the error of the plume infrared thermal image is reduced by more than 50%.