bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S14 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms
Authors: Tian Jane , Ashique Amir M. , Weeks Sabrina , Lan Tian , Yang Hong , Chen Hung-I Harry , Song Christina , Koyano Kikuye , Mondal Kalyani , Tsai Daniel , Cheung Isla , Moshrefi Mehrdad , Kekatpure Avantika , Fan Bin , Li Betty , Qurashi Samir , Rocha Lauren , Aguayo Jonathan , Rodgers Col , Meza Marchelle , Heeke Darren , Medfisch Sara M. , Chu Chun , Starck Shelley , Basak Nandini Pal , Sankaran Satish , Malhotra Mohit , Crawley Suzanne , Tran Thomas-Toan , Duey Dana Y. , Ho Carmence , Mikaelian Igor , Liu Wenhui , Rivera Lee B. , Huang Jiawei , Paavola Kevin J. , O'Hollaren Kyle , Blum Lisa K. , Lin Vicky Y. , Chen Peirong , Iyer Anjushree , He Sisi , Roda Julie M. , Wang Yan , Sissons James , Kutach Alan K. , Kaplan Daniel D. , Stone Geoffrey W.
Published: May 2024

Supplementary Figure S14
Figure S4 from Chronic Stress Exacerbates the Immunosuppressive Microenvironment and Progression of Gliomas by Reducing Secretion of CCL3
Authors: Wang Xu , Zhang Long , Zhou Yi , Wang Yan , Wang Xiang , Zhang Yining , Quan Ankang , Mao Yufei , Zhang Yu , Qi Ji , Ren Zhongyu , Gu Linbo , Yu Rutong , Zhou Xiuping
Published: May 2024

Supplementary Figure 4. Chronic stress inhibited migration ability of TAMs (Related to Fig.4)
Figure S1 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms
Authors: Tian Jane , Ashique Amir M. , Weeks Sabrina , Lan Tian , Yang Hong , Chen Hung-I Harry , Song Christina , Koyano Kikuye , Mondal Kalyani , Tsai Daniel , Cheung Isla , Moshrefi Mehrdad , Kekatpure Avantika , Fan Bin , Li Betty , Qurashi Samir , Rocha Lauren , Aguayo Jonathan , Rodgers Col , Meza Marchelle , Heeke Darren , Medfisch Sara M. , Chu Chun , Starck Shelley , Basak Nandini Pal , Sankaran Satish , Malhotra Mohit , Crawley Suzanne , Tran Thomas-Toan , Duey Dana Y. , Ho Carmence , Mikaelian Igor , Liu Wenhui , Rivera Lee B. , Huang Jiawei , Paavola Kevin J. , O'Hollaren Kyle , Blum Lisa K. , Lin Vicky Y. , Chen Peirong , Iyer Anjushree , He Sisi , Roda Julie M. , Wang Yan , Sissons James , Kutach Alan K. , Kaplan Daniel D. , Stone Geoffrey W.
Published: May 2024

Supplementary Figure S1
Figure S2 from Chronic Stress Exacerbates the Immunosuppressive Microenvironment and Progression of Gliomas by Reducing Secretion of CCL3
Authors: Wang Xu , Zhang Long , Zhou Yi , Wang Yan , Wang Xiang , Zhang Yining , Quan Ankang , Mao Yufei , Zhang Yu , Qi Ji , Ren Zhongyu , Gu Linbo , Yu Rutong , Zhou Xiuping
Published: May 2024

Supplementary Figure 2. Chronic stress exacerbates the formation of immunosuppressive microenvironment in gliomas (Related to Fig.2)
Figure S1 from Chronic Stress Exacerbates the Immunosuppressive Microenvironment and Progression of Gliomas by Reducing Secretion of CCL3
Authors: Wang Xu , Zhang Long , Zhou Yi , Wang Yan , Wang Xiang , Zhang Yining , Quan Ankang , Mao Yufei , Zhang Yu , Qi Ji , Ren Zhongyu , Gu Linbo , Yu Rutong , Zhou Xiuping
Published: May 2024

Supplementary Figure 1. Successful construction of the mice model for depression (Related to Fig.1)
Figure S3 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Authors: Zhang Qunfang , Zheng Fang , Chen Yuchao , Liang Chun-Ling , Liu Huazhen , Qiu Feifei , Liu Yunshan , Huang Hongfeng , Lu Weihui , Dai Zhenhua
Published: May 2024

The gene or protein expression of GPC3-CAR.
Figure S3 from ANXA3-Rich Exosomes Derived from Tumor-Associated Macrophages Regulate Ferroptosis and Lymphatic Metastasis of Laryngeal Squamous Cell Carcinoma
Authors: Xu Licheng , Li Wenjing , Liu Danxi , Cao Jing , Ge Jingchun , Liu Xinyu , Wang Yue , Teng Yujian , Liu Pengyan , Guo Xinyue , He Chen , Liu Ming , Tian Linli
Published: May 2024

Figure S3. TAMs-derived-exo-ANXA3 inhibits ferroptosis in LSCC cells.
Figure S2 from ANXA3-Rich Exosomes Derived from Tumor-Associated Macrophages Regulate Ferroptosis and Lymphatic Metastasis of Laryngeal Squamous Cell Carcinoma
Authors: Xu Licheng , Li Wenjing , Liu Danxi , Cao Jing , Ge Jingchun , Liu Xinyu , Wang Yue , Teng Yujian , Liu Pengyan , Guo Xinyue , He Chen , Liu Ming , Tian Linli
Published: May 2024

Figure S2. ANXA3 promotes M2-like polarization of macrophages by activating the AKTGSK3β-β-catenin pathway.
Data from Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer
Authors: Blise Katie E. , Sivagnanam Shamilene , Betts Courtney B. , Betre Konjit , Kirchberger Nell , Tate Benjamin J. , Furth Emma E. , Dias Costa Andressa , Nowak Jonathan A. , Wolpin Brian M. , Vonderheide Robert H. , Goecks Jeremy , Coussens Lisa M. , Byrne Katelyn T.
Published: May 2024

Abstract
Tumor molecular data sets are becoming increasingly complex, making it nearly impossible for humans alone to effectively analyze them. Here, we demonstrate the power of using machine learning (ML) to analyze a single-cell, spatial, and highly multiplexed proteomic data set from human pancreatic cancer and reveal underlying biological mechanisms that may contribute to clinical outcomes. We designed a multiplex immunohistochemistry antibody panel to compare T-cell functionality and spatial localization in resected tumors from treatment-naïve patients with localized pancreatic ductal adenocarcinoma (PDAC) with resected tumors from a second cohort of patients treated with neoadjuvant agonistic CD40 (anti-CD40) monoclonal antibody therapy. In total, nearly 2.5 million cells from 306 tissue regions collected from 29 patients across both cohorts were assayed, and over 1,000 tumor microenvironment (TME) features were quantified. We then trained ML models to accurately predict anti-CD40 treatment status and disease-free survival (DFS) following anti-CD40 therapy based on TME features. Through downstream interpretation of the ML models’ predictions, we found anti-CD40 therapy reduced canonical aspects of T-cell exhaustion within the TME, as compared with treatment-naïve TMEs. Using automated clustering approaches, we found improved DFS following anti-CD40 therapy correlated with an increased presence of CD44+CD4+ Th1 cells located specifically within cellular neighborhoods characterized by increased T-cell proliferation, antigen experience, and cytotoxicity in immune aggregates. Overall, our results demonstrate the utility of ML in molecular cancer immunology applications, highlight the impact of anti-CD40 therapy on T cells within the TME, and identify potential candidate biomarkers of DFS for anti-CD40–treated patients with PDAC.
Table S7 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

Poly-Seq data of nucleotide metabolism genes
Table S6 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

mRNA expression of nucleotide metabolism genes
Table S4 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

CRISPR screen results for mouse Yumm5.2 cells
Figure S1 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

Knockdown of p16 or Cdkn2a in human and mouse melanoma cell lines, respectively, and DepMap dependency score data based on CDKN2A expression. Related to Figure 1.
FIGURE 6 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

De novo purine synthesis and one carbon metabolism genes are associated with worse overall survival in metastatic melanomas. Data from TCGA Skin Cutaneous Melanoma PanCancer Atlas (367 metastatic melanomas). Raw data can be found in Supplementary Table S8. A,De novo purine synthesis and one carbon metabolism genes in TCGA metastatic melanoma samples. Red indicates increased mRNA expression. Blue indicates decreased mRNA expression. Overall survival probability of patients with alterations in de novo purine synthesis and one carbon metabolism genes (B), de novo pyrimidine genes (C), overall nucleotide biosynthesis genes (D), and nucleotide salvage genes (E). log-rank P-value and 95% confidence interval.
FIGURE 5 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

shp16 tumors are more sensitive to the antifolate methotrexate. A and B, SKMEL28 human melanoma cells were infected with lentivirus expressing a shRNA targeting GFP (shCont) or p16 (shp16). A total of 107 cells were subcutaneously implanted into athymic nude mice. Mice were treated with vehicle controls or methotrexate (MTX). Individual tumor growth curves in shp16 tumors (A) and shCont tumors (B). Shown are growth rates ± SE. Linear mixed-model group comparisons: shp16 versus shCont P < 0.001; shCont: MTX versus vehicle P = 0.734; shp16: MTX versus vehicle P = 0.031; (shp16: MTX vs. vehicle) versus (Control: vehicle vs. MTX) P = 0.002.
FIGURE 3 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

p16/CDKN2Alow cells are more sensitive to inhibitors of nucleotide metabolism. A, Table of inhibitors used in in vitro cell line studies. 1C metabolism = one carbon metabolism. B, SKMEL28 human melanoma cells were infected with lentivirus expressing a shRNA targeting p16 (shp16). shGFP was used as a control (shCont). Cells were treated with the indicated inhibitors and proliferation was assessed by crystal violet staining. IC50 and fold change (shp16 vs. shCont, FC) are indicated. Data from one of 2–3 independent experimental replicates are shown (n = 6). C, Increased drug sensitivity from DepMap data of cutaneous melanoma cell lines with high or low CDKN2A expression. Data are mean ± SD. t test. *, P < 0.05; **, P < 0.01.
Data from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

Abstract
p16 is a tumor suppressor encoded by the CDKN2A gene whose expression is lost in approximately 50% of all human cancers. In its canonical role, p16 inhibits the G1–S-phase cell cycle progression through suppression of cyclin-dependent kinases. Interestingly, p16 also has roles in metabolic reprogramming, and we previously published that loss of p16 promotes nucleotide synthesis via the pentose phosphate pathway. However, the broader impact of p16/CDKN2A loss on other nucleotide metabolic pathways and potential therapeutic targets remains unexplored. Using CRISPR knockout libraries in isogenic human and mouse melanoma cell lines, we determined several nucleotide metabolism genes essential for the survival of cells with loss of p16/CDKN2A. Consistently, many of these genes are upregulated in melanoma cells with p16 knockdown or endogenously low CDKN2A expression. We determined that cells with low p16/CDKN2A expression are sensitive to multiple inhibitors of de novo purine synthesis, including antifolates. Finally, tumors with p16 knockdown were more sensitive to the antifolate methotrexate in vivo than control tumors. Together, our data provide evidence to reevaluate the utility of these drugs in patients with p16/CDKN2Alow tumors as loss of p16/CDKN2A may provide a therapeutic window for these agents.
Significance:
Antimetabolites were the first chemotherapies, yet many have failed in the clinic due to toxicity and poor patient selection. Our data suggest that p16 loss provides a therapeutic window to kill cancer cells with widely-used antifolates with relatively little toxicity.
Behaviorally Conditioned Immune Responses: “To Learn New Things, Read Old Books & Papers”
Authors: Schedlowski Manfred , Hadamitzky Martin
Published: May 2024

More than a century ago, experimental work and clinical observations revealed the functional communication between the brain and the peripheral immune system. This is documented on the one hand by studies firstly demonstrating the effects of catecholamines on the circulation of leukocytes in experimental animals and humans and on the other hand via the work of Russian physiologist Ivan Petrovic Pavlov and his co-workers, reporting observations that associative learning can modify peripheral immune functions. This work later fell into oblivion, since little was known about the endocrine and immune system’s function and even less about the underlying mechanisms of how learning, a central nervous system activity, could affect peripheral immune responses. In this article, we embark on a fascinating exploration of the historical trajectory of behaviorally conditioned immune responses. We'll pay homage to the visionary scientists who laid the groundwork for this field of research, tracing its evolution from early theories of how associative learning can affect immunity to the modern-day insights that behavioral conditioning of pharmacological responses can be exploited to improve the efficacy of medical interventions for patients.
Antibacterial Activity of Stingless Bee Propolis (Heterotrigona itama) Ethanol Extract on Dental Root Canal Bacteria Growth in Vitro
Authors: Takdir Azizah Qothrunnada , Purnamasari Cicih Bhakti , Ompusunggu Novelin Yohana , Paramita Swandari , Yani Sinar
Published: May 2024

Introduction: Pulp and periapical tissue problems are 7th out of the top 10 diseases. Propolis from stingless bees is a natural substance that has been proven its efficacy in treating the diseases. Additionally, it is categorized safe for humans. This study aimed to determine the antibacterial activity of stingless bee propolis (Heterotrigona itama) ethanol extract on dental root canal bacterial growth in vitro. Method: This study was an experimental study with a posttest-only control group design and consisting of six treatment groups with concentrations of 3,000; 6,000; 12,000; and 24,000 ppm of stingless bee propolis, as well as a positive and negative control. Each treatment was repeated four times. Result: The result showed that there were no clear zones at concentrations of 24,000 ppm, but a clear zones appeared at concentrations of 3,000; 6,000; and 12,000 ppm. Stingless bee propolis ethanol extract is efficient against bacteria. At a concentration of 3,000 ppm, the inhibition zone's maximum circumference was visible.
Development and Evaluation of an Optimized Energy Recovery System from Excess Heat of a Compressed Air System
Authors: Mañego Andrew S.
Published: May 2024

The aim of this study is to build a bounded optimized energy recovery system from the compressed air system’s excess heat. It is important to concentrate on the use of products that satisfy the requirements for performance and sustainability, as well as the need for energy that will be optimized. Purposive sampling is used to select the respondents, using quantitative research, specifically both descriptive and developmental methods. The researcher utilized a decision support tool developed by Kolaitis et al., (2020) as the primary research instrument of the study. The adopted tool was slightly modified to suit the assessment needs of the developed energy utilization system. All the main criteria components are interpreted as highly sustainable. The researcher utilized log sheets to determine the performance of the study. Finally, paired t-test was used to determine whether there was a significant difference in the performance of the study. The performance of the optimized energy after the implementation of the project was statistically higher than the performance of the optimized energy before the implementation of the project. The researcher concluded that the performance of the optimized energy recovery system from excess heat of a compressed air system after the installation and operation was effective and efficient based on the ratings of respondents and descriptive measures on the log sheet. For this kind of innovation, the manufacturing company with the same equipment should adopt and sustain it for potential energy savings and protect mother nature.
Crowdfunding and Social Capital: A Pathway for The Internationalization of MSMEs and Social Enterprises?
Authors: Vergara Kimberly Christie , Vergara Raymond Allan
Published: May 2024

Micro and social entrepreneurs face multiple challenges, including limited access to funding, knowledge systems, networks, and markets, which limit the growth and development of their ventures. This study seeks to understand how the participation in crowdfunding and its utilization to internationalize can help micro and social enterprises address challenges through social capital. Through a narrative review of literature anchored on the resource-based and knowledge-based theories of the firm and the theory of social capital, this study finds that crowdfunding provides access to funding, knowledge systems, and networks. Moreover, the participation in crowdfunding provides access to large, international markets. However, despite these benefits, there remains challenges to micro and social enterprise participation in crowdfunding as there is low awareness and adoption in developing countries. Furthermore, there is still question on crowdfunding’s viability as an internationalization strategy. The study ends by identifying directions for future research.
The Mediating Effects of Generational Affiliation to The Influence of Principals’ Digital Leadership on Teachers’ Technological Self-Efficacy
Authors: Paunil Lawrence Oliver V.
Published: May 2024

New technology developments are rapidly altering the teaching and learning environment. Schools require leaders who can assist the transformation process and promote a digital culture of learning. As a result, this study aims to determine the influence of the respondents’ perceived digital leadership of principals on their technological self-efficacy when mediated by generational affiliation among private schools in Quezon province. Two instruments were used in this study: The principals’ Digital Leadership questionnaire, which is based on the International Society for Technology Education (ISTE) standard for Education Leaders (2022) was administered to school principals/heads, while Teachers’ Technological Self-Efficacy Questionnaire, which is based on the ISTE standard for Educators (2022) was administered to teachers. Descriptive and Inferential analysis was carried out using SPSS. The findings showed that the respondents significantly demonstrated generational work-related orientation, digital leadership, and technological self-efficacy. Furthermore, when respondents were categorized by generational affiliation, there were no significant differences in their work-related orientation, digital leadership, and technological self-efficacy. On the other hand, there was a significant influence of the principals’ digital leadership on teachers’ technological self-efficacy. Moreover, the respondents' generational affiliation/work-related orientation mediates the direct influence of Principals’ Digital Leadership on the Teachers’ Technological Self-efficacy. Principal preparation programs and teacher training programs may include technology-based leadership to improve technology integration in classrooms. It is advised that further studies be conducted on digital leadership and technical self-efficacy for administrators and teachers.
Ina- Manggagawa- Mag-aaral: The Lived Experiences, Challenges, Coping and Aspirations of Working- Student- Mothers
Authors: Sudweste Jennie Marie V. , Jumamil Ana Nelia L.
Published: May 2024

Many individuals are pursuing graduate degrees while working and raising children. The aim of this study is to explore the lived experiences, challenges, coping, and aspirations of working-student- mothers who fulfill employment, academic, and family obligations. The mother's educational and work efforts provide the necessary information, needed skills, and a desirable attitude for a family's general well-being. The study intends explicitly to 1. explore the experiences and challenges faced by working student mothers. 2. Investigate their coping strategies and aspirations for managing different roles. 3. understand their current living situation. The participants consisted of twelve (12) mothers who had a minimum of two dependents, were enrolled in a master's degree program, and were employed in an organization. Participants were administered a brief demographic questionnaire and engaged in a semi-structured interview. This study utilized interpretative phenomenology analysis. The latest findings emphasize that participants shared their experience of navigating the complexities of managing coursework, jobs, and caregiving responsibilities, which led to feeling overwhelmed. The stress factor was primarily attributed to low income and inadequate childcare expenses. However, they employed effective coping strategies using work-life balance, such as social support and time management. Pursuing a master's degree encompassed the opportunity to enhance their abilities and expand their knowledge and earning potential. The study revealed that they exhibited strong motivation and perseverance, with solid career aspirations driving their academic and professional pursuits, benefiting themselves and their families.
Sustainable Micro-Social Enterprises in India: A Quantitative Study of Crucial Factors Leading to Their Financial Sustainability
Authors: D'Mello Rolvin Vincent
Published: May 2024

Social enterprises strive to create social value by providing innovative solutions to various socio-economic and developmental problems. Given the harsh economic terrain, the key question is how these organizations traverse the path to financial sustainability to fulfil their social mission. Thus often challenged to either change scope or shut down. There is a dearth of research on micro-social enterprises and their strategies for financial sustainability. This study gathered data through an online survey platform from 121 social enterprises, which were more than 3 years of age based in the Indian state of Maharashtra. Further, crucial insights were obtained by analyzing this data using two statistical software: Jamovi and PROCESS Macro of SPSS for serial mediation. The findings demonstrate that growth orientation positively and significantly influences financial sustainability, both directly, and indirectly through; product & service innovation, social capital and external funding, which was observed individually and in serial mediation. Thus revealing that all these factors have partial mediation on financial sustainability. However, the influence of growth orientation with all these factors is way higher than it does individually. There are several crucial paths for financial sustainability, however, the most crucial one is when growth orientation is in tandem with product & service innovations. By harnessing the synergies between growth-oriented strategies and intermediary variables, social enterprises can navigate challenges, seize opportunities, and advance their dual mission of financial sustainability as well as their social mission.
Improving the Cardiovascular Endurance of Teacher Education Students through the Utilization of the TikTok Application
Authors: Masangcay Ivan B. , Parungo John Paul A. , Cruz Jr. Salvador L.
Published: May 2024

Driven by the widespread usage of mobile applications, the expansive development of TikTok application has carried considerable challenges and opportunities to the Physical Education industry. Hence, it is imperative to examine the usefulness of this application to mitigate the low cardiovascular endurance of college students since the conduct of research to improve their physical activity engagement is still significant. Thus, this action research sought to improve the cardiovascular endurance of undergraduate teacher education students using the TikTok application as a tool for their physical activity. This study utilized a quantitative approach, specifically, the pretest-post-test design which is classified as quasi-experimental research. Using the normative data from YMCA 3-minute step test, 50 participants from the Bachelor of Elementary Education (BEEd) enrolled in their physical education classes were determined to be qualified based on their pre-test scorecards. Two groups were formed out of them: 25 in the experimental group who were exposed to the intervention and another 25 in the control group who were instructed using the standard discussion. Descriptive statistics and ANOVA-type test analysis were utilized using participants' pre-test and post-test results to ascertain the efficacy of the intervention. Results unveiled that the intervention has significantly improved the experimental group's post-test scores compared to the control group since the post-test results of the control group remained almost stagnant, indicating the intervention's effectiveness by rejecting the null hypothesis. Therefore, this action research inferred that the intervention has efficiently strengthened the cardiovascular endurance of the 1st year BEEd students.
Social Marketing: Teori dan Praktik di Indonesia
Authors: Destrity Nia Ashton , Oktaviani Fitri Hariana , Avina Diyah Ayu Amalia , Illahi Azizun Kurnia , Tamitiadini Dian , Avicenna Fitria , Syauki Wifka Rahma
Published: May 2024

Buku ini merupakan jenis buku ajar untuk mata kuliah Social Marketing yang merupakan mata kuliah lintas disiplin dan dikaji oleh mahasiswa pada sejumlah program studi antara lain Ilmu Komunikasi, Manajemen, dan Ilmu Kesehatan Masyarakat. Social marketing merupakan aplikasi dari prinsip dan teknik pemasaran komersial untuk menciptakan perubahan perilaku dalam rangka meningkatkan kualitas kehidupan sosial masyarakat. Buku ini menyajikan penjelasan dan diskusi secara komprehensif mengenai social marketing dari sudut pandang teoretis dan praktis. Diskusi mengenai social marketing ini disajikan mulai dari pengantar social marketing; teori-teori dalam social marketing; tahapan dalam social marketing planning; riset dalam social marketing; segmentasi, targeting, dan positioning dalam social marketing; social marketing mix; daya tarik pesan dan saluran pemasaran dalam social marketing; moving upstream; relational thinking; kompetisi dalam social marketing; etika dalam social marketing; community-based social marketing, serta monitoring dan evaluasi dalam social marketing. Buku ini juga menyajikan contoh praktik (studi kasus) di tingkat internasional dan di Indonesia.
Program Siaran Lokal di Tengah Persaingan Global
Authors: Safitri Reza , Alfira Nisa , Amalia Riski
Published: May 2024

Buku ini lahir dari proses penelitian yang dilaksanakan oleh para peneliti pada tahun 2020. Didorong oleh keinginan untuk mengidentifikasi dan mengkaji fenomena penyiaran lokal, penulis ingin mendialogkan tentang fenomena penyiaran lokal terutama dalam konteks persaingan global. Industri komunikasi global berubah cepat. Para pelaku di bidang media penyiaran pun dalam proses beradaptasi dengan beragam perubahan yang ada.
Fisiologi Hewan Akuatik
Authors: Maimunah Yunita , Kilawati Yuni , Amrillah Attabik Mukhammad
Published: May 2024

Lingkungan air memiliki karakteristik yang berbeda dengan lingkungan darat, seperti konsentrasi oksigen yang rendah, salinitas yang bervariasi, dan tekanan hidrostatik yang tinggi. Untuk dapat bertahan hidup di lingkungan air, hewan air telah mengembangkan berbagai adaptasi fisiologis. Buku ini ditujukan untuk mendukung mata kuliah Fisiologi Hewan Air. Buku ini membahas topik-topik tentang Respirasi, Osmoregulasi dan Termoregulasi, Otot dan Keseimbangan, Fisiologi Pencernaan, Sirkulasi Darah, Reproduksi, Syaraf, Hormon, dan Kesejahteraan Hewan Air. Buku ini ditulis dengan bahasa yang mudah dipahami dan dilengkapi dengan ilustrasi untuk mempermudah pemahaman. Penulis berharap buku ini dapat menjadi sumber informasi yang bermanfaat bagi mahasiswa, peneliti, dan praktisi yang tertarik mempelajari fisiologi hewan air.
Entrepreneur Muslim: Kekuatan, Tantangan, dan Keberlanjutan Bisnis
Authors: Thoyib Armanu , Risfandini Andini , Kuncoro Suryo , Wahjunianto Hamy
Published: May 2024

Buku "Entrepreneur Muslim: Kekuatan, Tantangan, dan Keberlanjutan Bisnis” ini membahas tentang individu yang mengidentifikasi dirinya sebagai seorang pengusaha muslim. Pengusaha muslim memiliki kekuatan moral (akhlak) dan menjalankan usahanya berdasarkan prinsip-prinsip ajaran Islam, yaitu Al-Qur’an dan Sunah Rasulullah saw. untuk mencapai kesuksesan sebagai seorang pengusaha muslim, terdapat langkah-langkah dan panduan yang harus diikuti. Buku ini terdiri dari empat bab yang akan mengulas topik-topik berikut. Kekuatan Entrepreneur Muslim: Bab ini membahas kekuatan “akhlak” sebagai kekuatan pada internal pribadi pengusaha muslim, yang dibentuk oleh 3 pilar utama, yaitu: Islam, Iman, dan Ihsan, serta dimensi Entrepreneur Muslim. Kekuatan “akhlak” didukung dan diperkuat oleh faktor-faktor eksternal, yaitu: faktor sosial, budaya, hukum, dan politik. Kiat Sukses Menjadi Entrepreneur Muslim: Bagian ini menyoroti pentingnya niat yang baik sebelum memulai sebuah pekerjaan, karena niat yang baik memiliki nilai ibadah dan memiliki arah dan tujuan yang jelas, serta langkah strategis yang nyata. Peluang Entrepreneur Muslim: Suatu usaha atau bisnis tidak lepas dari persaingan; bab ini mengidentifikasi peluang usaha, menguraikan tantangan yang mungkin dihadapi dalam membangun bisnis, dan memberikan kiat sukses untuk mengatasi tantangan dalam berusaha. Keberlanjutan Usaha Entrepreneur Muslim: Bab ini memperjelas, bahwa Keberlanjutan Bisnis bagi seorang Entrepreneur Muslim ada pada perilaku dan sifat-sifat yang melekat pada pribadinya dalam bentuk kelincahan, kolaborasi, kemampuan untuk merespons perubahan, serta kreativitas dan inovasi. Buku ini juga membahas berbagai strategi pengembangan usaha Entrepreneur Muslim, termasuk bagaimana memiliki pola pikir sebagai Entrepreneur Muslim, dan strategi pengembangan usaha kecil, serta penggunaan strategi Resource-based View.
Rekayasa Jaringan (Tissue Engineering)
Authors: Permata Fajar Shodiq , Paramanandi Dini Agusti , Amalia Mifta Rizqina
Published: May 2024

Rekayasa Jaringan (Tissue Engineering) adalah aplikasi prinsip biologi, kimia dan teknik untuk perbaikan, pemulihan, atau regenerasi jaringan tubuh menggunakan biomaterial, sel, dan faktor pendukung baik secara sendiri maupun kombinasi. Aplikasi ini memberikan manfaat yang menjanjikan di masa depan sebagai pengobatan penyakit degeneratif seperti gangguan jantung, ginjal, kulit dan lain-lain. Rekayasa jaringan ini terdiri atas sel, biomaterial, dan growth factor. Buku ini menjelaskan berkaitan pendahuluan rekayasa jaringan meliputi sejarah tissue engineering, pusat tissue engineering dunia, dan prinsip tissue engineering. Selanjutnya buku ini menjelaskan secara detail terkait masing-masing komponen penyusun rekayasa jaringan meliputi stem cell, biomaterial, dan growth factor. Kelebihan buku ini adalah dijelaskan pula berkaitan metode pembuatan rekayasa jaringan seperti metode bottom up dan top down. Teknologi ini telah membuka peluang bahwa jaringan atau organ dapat dicetak di luar tubuh sesuai kebutuhan spesifik masing-masing pasien. Oleh karena itu, metode bottom up terkait erat dengan personalized medicine. Buku ini juga memberikan contoh rekayasa jaringan pada jaringan keras (hard tissue engineering) seperti rekayasa jaringan tulang, gigi, dan pin tulang biodegradable. Selain itu, juga memberikan contoh pembuatan rekayasa jaringan lunak (soft tissue engineering) seperti rekayasa jaringan kulit, saraf, kartilago, jantung dan pembuluh darah. Berdasarkan potensi rekayasa jaringan dalam menjawab kebutuhan jaringan cangkok masa depan di tingkat global sebagai pengobatan regeneratif (regenerative medicine), maka banyak komunitas keilmuan internasional yang terkait tissue engineering dan banyak industri kesehatan bidang tissue engineering secara global.
Bandeiras nacionais e retórica política: uma comparação semiótica entre Itália e Brasil
Authors: Leone Massimo
Published: May 2024

This study explores the semantic and symbolic complexity of flags in contemporary culture. Discussing specific examples in Italy, it analyzes how a variety of contexts employ flags, showing their socio-political, communication, and cultural connotations. It uses semiotic theories to describe the relation between flags and their meanings in different situations, highlighting the ambiguity inherent in these symbols and their role in expressing national identity, protest, and power. This study also addresses the influence of material, color, and context on the interpretation of flags.
Nelson Rodrigues e o drama como espírito de repetição do capitalismo no Brasil
Authors: Delmanto Ivan
Published: May 2024

This article deals with the particular process of Brazilian theater’s formation through two stagings of the play Family album by Nelson Rodrigues: we start from the naturalistic staging of the play’s premiere, in 1967, and proceed to the conception of the eternal return in Antunes Filho’s staging, Nelson Rodrigues The eternal return, of 1981. Antunes’ staging would have congured, through allegorical procedures, an aspect already present in formal issues of Nelson Rodrigues’ dramaturgy the – eternal return – but still obscured by the tradition of national comedy of customs, which only emerged from the Brazilian historical reality at the end of the 1970’s. This reality is characterized, in its turn, by the end of the economic miracle and by dismantling the idea of the country’s appointment with progress. Without an encounter with progress, only the eternal repetition would be left to us.
Sex Differences in Cardiovascular Outcomes in Patients With Kidney Failure
Authors: Shah Silvi , Christianson Annette L. , Meganathan Karthikeyan , Leonard Anthony C. , Crews Deidra C. , Rubinstein Jack , Mitsnefes Mark M. , Schauer Daniel P. , Thakar Charuhas V.
Published: May 2024

Background

Cardiovascular disease is the leading cause of mortality in patients with kidney failure, and their risk of cardiovascular events is 10 to 20 times higher as compared with the general population.

Methods and Results

We evaluated 508 822 patients who initiated dialysis between January 1, 2005 and December 31, 2014 using the United States Renal Data System with linked Medicare claims. We determined hospitalization rates for cardiovascular events, defined by acute coronary syndrome, heart failure, and stroke. We examined the association of sex with outcome of cardiovascular events, cardiovascular death, and all‐cause death using adjusted time‐to‐event models. The mean age was 70±12 years and 44.7% were women. The cardiovascular event rate was 232 per thousand person‐years (95% CI, 231–233), with a higher rate in women than in men (248 per thousand person‐years [95% CI, 247–250] versus 219 per thousand person‐years [95% CI, 217–220]). Women had a 14% higher risk of cardiovascular events than men (hazard ratio [HR], 1.14 [95% CI, 1.13–1.16]). Women had a 16% higher risk of heart failure (HR, 1.16 [95% CI, 1.15–1.18]), a 31% higher risk of stroke (HR, 1.31 [95% CI, 1.28–1.34]), and no difference in risk of acute coronary syndrome (HR, 1.01 [95% CI, 0.99–1.03]). Women had a lower risk of cardiovascular death (HR, 0.89 [95% CI, 0.88–0.90]) and a lower risk of all‐cause death than men (HR, 0.96 [95% CI, 0.95–0.97]).

Conclusions

Among patients undergoing dialysis, women have a higher risk of cardiovascular events of heart failure and stroke than men. Women have a lower adjusted risk of cardiovascular mortality and all‐cause mortality.
Contribution of Virtual Reality to the Reproduction of Social Interaction Characteristics in Neuropsychology: A Systematic Review of the Literature
Authors: Jollivet Maxime , Besnard Jeremy , Banville Frederic , Allain Philippe
Published: May 2024

Sociocognitive difficulties are observed in many pathologies associated with brain lesions or atypical brain functioning. The development of virtual reality offers an opportunity to assess this dimension from an interactionist perspective and to increase the ecological validity of the material used. However, this approach can be operationalized and conceptualized in a variety of ways. To understand these aspects, we conducted a systematic review of articles found in the PubMed, PubMed Central, and ScienceDirect databases, following PRISMA-P guidelines. A corpus of 48 articles was identified and analyzed in terms of the experimental devices used, to gauge the extent to which they reproduced the characteristics of real-world social interactions, as well as the associated conceptions. Results suggested that interactionist research lies on a continuum between ecological validity (studies exploring interactions via general functions) and a high level of experimental control (exploration of interactions with respect to specific processes). They are discussed in terms of the operationalization and objectification of interactionism.
Early Church as Utopian Cult: The Case of Hebrews
Authors: Beavis Mary Ann
Published: May 2024

This article uses cultic studies to explicate the development of the earliest churches, using Hebrews as a case study. “Cult” is defined as a group that suppresses individuality and critical thinking, demands intense commitment and loyalty to an individual or ideology, and curtails or eliminates personal autonomy to be replaced by the cult’s worldview. The cult-like attributes of the early ecclesia are summarized, followed by a brief introduction to cultic studies, with particular reference to the characteristics of contemporary cults, suggesting that an under-appreciated aspect of cultic appeal is the offer of utopian promises. Finally, the bite (Behavior, Information, Thoughts, Emotions) model of coercive control is applied to the hortatory sections of Hebrews and the utopian hopes held out by the author. The article concludes that the community behind Hebrews shows many characteristics of a high demand cult as defined by cultic studies.
Additions to Crepidotus species (Basidiomycota): Six new species and two new records from Thailand
Authors: PHONEMANY MONTHIEN , SYSOUPHANTHONG PHONGUEN , THONGKLANG NARITSADA
Published: May 2024

Six new species and two new records of Crepidotus are described from Thailand. Macroscopic and microscopic descriptions with photoplates, as well as a multigene phylogeny, are provided. Crepidotus chiangraiensis sp. nov. is recognized as densely velutinous with white hairs longer near the point of attachment, not striate margin, and not hygrophanous. Crepidotus- flavocarpus sp. nov. is recognized by yellow to yellowish pileus basidiomata, margin discolorous paler yellow, densely velutinous with white hairs near the point of attachment, smooth globose basidiospores, and inverse hymenophoral trama. Crepidotus thailandicus sp. nov. is recognized by a tomentose surface with white hair when primordial to early stages and then disappearing with age when mature present long translucent-striate reward to the point of attachment becoming fade away at central. Crepidotus roseocarpus sp. nov. is recognized by large basidiomata, pileus, lamellae, and context are pastel pink, concolorous darker pink at the margin, hymenophoral trama convergent, with cylindrical terminal elements. Crepidotus-ungulatus sp. nov. is recognized by ungulate basidiomata, brownish orange near the point of attachment, the basidiomata color changed to light brown in three hours, and the margin is concolorous to the surface of the pileus. Crepidotus viscidus sp. nov. is recognized by white semicircular pileus, translucent-striate with gray to dark grey margin, lamellae pale orange to orange-white, glutinous context, smooth basidiospore and hymenophoral trama present regular form. Crepidotus lateralipes and C. striatus are reported as new records to Thailand.
A new species of Platanthera (Orchidaceae, Orchideae) from southeast of Xizang, China
Authors: LIN DONGLIANG , LI JIANWU , YE CHAO , WEN HAIXIA , JIN XIAOHUA
Published: May 2024

A new species of orchid, Platanthera medogensis, was described and illustrated from Xizang Autonomous Region, China. P. medogensis is close to P. bakeriana and P. chiloglossa, but is readily distinguished from the latter by having ovate-lanceolate lip concave at base with two calli, linear visidium, two stigmas below the rostellum. Molecular phylogenetic analysis based on five markers (nrITS, matK, psbA-trnH, rbcL, trnL-F) revealed that P. medogensis is sister with P. exelliana by full support.
Molecular phylogenetic studies on Asparagus (Asparagaceae) revealed the position of the highly endangered Irano-Turkish halophytic species A. lycaonicus P.H.Davis related to A. officinalis L.
Authors: AKHANI HOSSEIN , ABDOLLAHI HUSSAINI , ÜRKER OKAN , MALEKMOHAMMADI MARYAM
Published: May 2024

Asparagus lycaonicus P.H.Davis (Asparagaceae), a highly interesting halophytic species was found in two disjunct populations of ca. 1550 km aerial distance, one in Central Anatolia (Bolluk Salt Lake) and the other in Central Iran (Meyghan Salt Lake). Using one nuclear phytochrome C (PHYC) and two plastid regions (trnH-psbA and trnD-T) the phylogenetic position of this Irano-Turkish endemic species was studied. In contrast to low resolution of plastid sequences, the PHYC provides good resolution for understanding species level phylogeny in SW Asian Asparagus. Molecular data confirms a conspecific position of the two disjunct localities in Turkey and Iran and their position in a clade containing cultivated Asparagus and many other Irano-Turkish species. Asparagus lycaonicus is extremely rare in Iran and since its discovery in 1986, it has never been rediscovered in Iran, even in its initial collection site. Intensive land use activities, water level changes and the passage of Arak wastewater into the Meyghan Salt Lake area has drastically changed the habitat of A. lycaonicus and might have caused its extinction. Since its discovery in 1960 in Turkey, the species is only found in a small area around and inside a sodic extraction factory around Bolluk Lake. Considering the critical condition of its populations in Iran and Turkey, we evaluate the conservation status of Asparagus lycaonicus as Critically Endangered (CR). In conclusion we urge the authorities to implement in situ measures for conservation and restoration of the habitats of A. lycaonicus, a halophytic species related to cultivated Asparagus. The taxonomic status of some newly described Asparagus from Iran is discussed with reducing A. touranensis Hamdi & Assadi to synonym of A. griffithii Baker., A. khorasanensis Hamdi & Assadi to synonym of A. breslerianus Schult. & Schult.f, and Asparagus bojnurdensis Hamdi & Assadi to synonym of A. verticillatus L.
A new species of Croton sect. Geiseleria (Euphorbiaceae) from Brazil, supported by macro- and micromorphological data
Authors: DA SILVA MARCOS JOSÉ , SODRÉ RODOLFO CARNEIRO , ALONSO ALEXANDRE ANTONIO , DOS SANTOS IGOR SOARES
Published: May 2024

Taxonomic studies on the genus Croton in the Midwest region of Brazil enabled the analysis of about 700 collections from all over the country. Three of these collections were identified as a new species, Croton piriquetifolius, which is described and illustrated here. We also give a preliminary evaluation of its conservation status, provide data on flowering and fruiting seasons, geographic distribution environmental preferences, as well as its systematic position. The new species is compared macro- and micromorphologically with C. adamantinus, C. glandulosus and C. eremophilus, with which it resembles or has been confused in herbaria. Morphological (e.g., presence, shape, and location of the acropetiolar nectaries, presence, and distribution of glands on stipules, presence, and size of pedicel on pistillate flower, integrity of styles, type, and location of trichomes) and anatomical (e.g., disposition of the stomata, contour of petiole and midrib, organization of vascular bundles, type of mesophyll, and types of trichomes) characters serve to differentiate the species studied.
Absidia thailandica sp. nov., an addition to the diversity of soil fungi from Thailand
Authors: HTET YEE MON , YASANTHIKA W. A. ERANDI , HURDEAL VEDPRAKASH G. , GOMES DE FARIAS ANTONIO ROBERTO
Published: May 2024

Absidia is ubiquitous and plays a critical function in biotechnology and medicine. It is characterized by single sporangiophores, in pairs or groups on stolons, bearing apophysate and pyriform sporangia with a deliquescent wall. This study isolated and proposed Absidia thailandica sp. nov. as an addition to Mucorales from Thailand. Phylogenetic analyses of IITS + LSU rDNA data showed that this species is related to A. ovalispora and A. soli. However, it differs from A. ovalispora by the absence of swollen parts on the sporangiophores and shape of rhizoids and can be distinguished from A. soli by the shape of rhizoids, size of sporangiospores and shape and size of columellae. This study expands the diversity of soil fungi in Thailand.