bluuebunny/crossref_metadata_2025 huggingface dataset:
La loi 2002-2 reste un bon outil pour diversifier les accompagnements sociaux et médico-sociaux et réussir l’articulation intégration-inclusion
Authors: Bauduret Jean-François
Published: December 2023

Les politiques publiques dédiées aux publics fragiles mettent dorénavant l’accent sur l’inclusion de ces personnes en milieu ordinaire de vie. Consacrée aux établissements et services sociaux et médico-sociaux, la loi de janvier 2002 pourrait para î tre en contradiction avec cette orientation. En fait, cette législation reste parfaitement compatible avec la doctrine actuelle de l’inclusion, dès lors qu’elle a anticipé et favorisé la mobilisation d’étayages diversifiés, consolidant les processus d’intégration et d’inclusion dans la cité.
« Un avenir après le travail » : une démarche de soutien aux personnes qui questionne la transformation de l’environnement de l’offre médico-sociale
Authors: Piriou Éric , Planchin Gwenaël
Published: December 2023

À la suite de la publication, en juin 2014, du rapport «  Zéro sans solution ». Le devoir collectif de permettre un parcours de vie sans rupture, pour les personnes en situation de handicap et pour leurs proches , coordonné par D. Piveteau, la démarche « Réponse accompagnée pour tous ( rapt ) » en reprenait, en 2018, les recommandations au sein de quatre axes. L’axe 2 portait plus spécifiquement sur les objectifs de transformation de l’offre, pour passer d’une logique de places et de filières à une logique de réponses adaptées aux besoins spécifiques et évolutifs des personnes. Dans un premier temps, nous rendrons compte ici du programme « Un avenir après le travail », de sa conception, de son déploiement, de ses réussites pour les personnes concernées et des défis qu’il soulève, comme illustration de la prise en compte de ces recommandations et des axes de la rapt (notamment le deuxième). Puis, dans un deuxième temps, à partir de ces enseignements, nous proposerons quelques pistes de réflexion sur ce qui « conditionne » l’évolution vers une « transformation “inclusive” de notre cadre de vie collectif », tel que le mentionne D. Piveteau dans son dernier rapport de février 2022.
Healing Trauma While Staying at Home: Using Telehealth to Conduct a Brief Treatment Program for Posttraumatic Stress Disorder
Authors: Lu Weili , Caldwell Barbara , Gao Ni , Oursler Janice , Wang Ke , Beninato John , Srijeyanthan Jeganee , Kumi Cindy , Sawyer Jeremy , Giacobbe Giovanna , Chen Yubi , Lin Karen Wei-Ru , Mueser Kim T.
Published: December 2023

Studies suggest that a three-session brief treatment program (Brief Relaxation, Education, and Trauma Healing [BREATHE]) can help treat posttraumatic stress disorder (PTSD) and symptoms of trauma; however, the program has not been examined via telehealth. Thus, the current study evaluated the feasibility of BREATHE delivered via telehealth. The intervention included breathing retraining and psychoeducation about PTSD and trauma. Thirty participants from the community with confirmed PTSD diagnoses participated in this telehealth program. Treatment retention was high, and participants showed decreased PTSD symptoms, posttraumatic cognitions, depression, anxiety, overall psychiatric symptoms, and internalized stigma and increased resiliency at posttreatment and 3-month follow up. Results suggest that a telehealth brief treatment program for PTSD is feasible and effective for individuals with PTSD. [
Journal of Psychosocial Nursing and Mental Health Services, 62
(7), 36–46.]
Soil conservation at the gully plot scale in the tropical volcanic landscape of Sumbing
Authors: Maulana Edwin , Sartohadi Junun , Setiawan Muhammad Anggri
Published: December 2023

Gully erosion has the ability to transport enormous amounts of soil material, which can degrade tropical volcanic landscapes as the highest potential of agricultural land. It is critical to understand gully erosion control activities in order to reduce the initiation and development of gully erosion. The goals of this study were to: 1) classify the different forms of gully control; 2) pinpoint the advantages and disadvantages of the gully control system; and 3) suggest forthcoming changes to gully erosion control systems in tropical volcanic landscapes. Field surveys employing random sampling were used to collect data on gully erosion points and control system. The findings of the study were explained using exploratory descriptive analysis. The research findings demonstrate that gully erosion control was accomplished through biological (vegetative), mechanical and combination methods, which were classified into nine categories. While mechanical methods have benefits in terms of strength in slowing the rate of gully growth, biological systems have advantages in terms of cost and energy. Adopting a continuous live wicker and wicker check dam system might assist in preventing cracks in the gully dimension. This study's findings can potentially reduce gully erosion susceptibility for local communities and are expected to be implemented globally in settings with similar features. Further research could be conducted on multiple tropical volcanoes with comparable issues in order to improve the performance of research results.
Asymptotic behavior of Levin-Nohel nonlinear difference system with several delays
Authors: Mesmouli Mouataz Billah , Tunç Cemil , Hassan Taher S. , Zaidi Hasan Nihal , Attiya Adel A.
Published: December 2023

In this manuscript, we considered a system of difference equations with delays and we established sufficient conditions to guarantee stability, asymptotic stability and exponential stability. In each type of stability, we created an appropriate space that guarantees us the existence of a fixed point that achieves the required stability.
Fuzzy adaptive event-triggered distributed control for a class of nonlinear multi-agent systems
Authors: Li Siyu , Li Shu , Liu Lei
Published: December 2023

In this work, we examine an adaptive and event-triggered distributed controller for nonlinear multi-agent systems (MASs). Second, we present a fuzzy adaptive event-triggered distributed control approach using a Lyapunov-based filter and the backstepping recursion technique. Next, the controller and adaptive rule presented guarantee that all tracking errors between the leader and the follower converge in a limited area close to the origin. According to the Lyapunov stability theory, this demonstrates that all other signals inside the closed loop are assured to be semi-globally, uniformly and finally constrained. Finally, simulation tests are conducted to illustrate the effectiveness of the control mechanism.
MIMO fuzzy adaptive control systems based on fuzzy semi-tensor product
Authors: Lyu Hongli , Lyu Yanan , Gao Yongchao , Qian Heng , Du Shan
Published: December 2023

Based on fuzzy semi-tensor product (STP) algorithms and fuzzy relation matrix (FRM) models, the design of an adaptive fuzzy controller was proposed in this paper for the multivariable nonlinear systems with uncertainty. The controlled multi-input-and-multi-output (MIMO) plants were expressed and processed first by FRM models and fuzzy STP operations, and then the indirect adaptive fuzzy control laws were designed. The tracking property of the FRM models was proved for the control objective of MIMO systems. The effectiveness of the novel matrix expression was verified by simulations of the tracking control on a two-link rigid robot manipulator. Results in simulation tests show that the proposed design of adaptive FRM control is efficient for nonlinear multivariables. Therefore, the proposed indirect fuzzy adaptive controllers can be extended to general matrix expression for MIMO nonlinear systems with fuzzy STP algorithms and FRM models and online approximate unknown parameters, according to required accuracy.
"Dubcon: Fanfiction, power, and sexual consent," by Milena Popova
Authors: Entrikin Kelsey Morgan
Published: December 2023

Milena Popova, Dubcon: Fanfiction, power, and sexual consent. Cambridge, MA: MIT Press, 2021, hardcover $30 (216 pp) ISBN 9780262045964.
Doing feminism through Chinese online fiction fandom
Authors: Du Yijia
Published: December 2023

To explore the connections between Chinese online fiction fandom and feminism, in-depth interviews were conducted with thirty-two Chinese women and nonbinary fans of online fiction. Online fiction fandom is both a counterpublic and an intimate public in which women and nonbinary fans are connected by a common interest, their feminist identities are formed through or emerge through participation in such a public, and their shared values and understanding of feminism create a closer sense of belonging and affective solidarity. Engaging with feminism through online fiction is a form of digital feminism, creating feminist consciousness among online fiction fans through literary and discursive constructs. Women-oriented online fiction has become a space for many young Chinese women and nonbinary people to criticize and challenge patriarchal gender norms and reflect on mainstream gender relations. This space continues to produce educational cultural resources that make feminist learning and practice a work in progress.
"Treat male idols as toys": A case study of Chinese self-centered shipper communities
Authors: Huang Dongni
Published: December 2023

The phenomenon of Chinese idol fans engaging in collective promotional actions has garnered significant academic attention, yet the marginalized community of fans who create secondary works and generate less revenue remains understudied. By examining a self-centered shipper community that rejects industry exploitation and instead seeks pleasure through creative fan art, I address the multifaceted ways in which fans engage with media and the complex power dynamics between fans and the idol industry.
“Are we friends or opponents?” Chinese idol fans’ relationship changes from online to off-line
Authors: Xiao Qing , Zheng Yuhang
Published: December 2023

This study focuses on how the relationships between Chinese idol fans change in the hybrid space of online and off-line, challenging assumptions about the harmony of fan relationships and highlighting the high fluidity of these relationships. Based on imaginary relationships with other fans, such as competition or cooperation, Chinese fans intentionally control their online and off-line fan identities, which are closely related to their fan activities in different spaces, that is, fans of the same idol cooperate online to enhance the idol's status in the entertainment industry, while off-line these fans need to compete for their idol's attention.
Identidades em contraste e a “síndrome da jagunçagem”: quando o desejo pela humanidade conduz à negação de si
Authors: Missiatto Leandro Aparecido Fonseca , Follmann José Ivo , Silva Leila Gracieli da
Published: December 2023

Este ensaio teórico se debruça sobre os antagonismos identitários vigentes para discutir pessoas que amparam em si elementos antagônicos quanto a suas identidades, como por exemplo, negros com comportamentos racistas, LGBTQIAPN+ homofóbicos e mulheres sexistas, fomentando reflexões e possibilidades. À luz da noção de sujeito genérico, humanidade/inumanidade, desejo por humanidade e colonialidade normativa e “síndrome da jagunçagem”, compreende-se esse fenômeno e sua perpetuação desde a negação de si ou alienação, na condição de sujeito, ao vívido pacto colonial nas ações governamentais vigentes no Brasil.
O Negro da Filadélfia: um estudo social
Authors: Xavier dos Santos Renato
Published: December 2023

A presente resenha do livro "O Negro da Filadélfia: um estudo social" destaca a obra como uma pesquisa social pioneira realizada por W.E.B. Du Bois, focada na condição dos Negros na cidade da Filadélfia. Através de uma análise minuciosa, Du Bois examina se existia um "problema Negro" ou se os desafios enfrentados pelos Negros eram resultado de questões sociais mais amplas influenciadas pelo preconceito racial.
Optical Characteristics of Copper-Doped-Perovskite Materials
Authors: Gamal Mohammed , Kandas Ishac , Hajjiah Ali , Shehata Nader
Published: December 2023

Doping of perovskite solar cells is a regularly used approach to adjust and modify the structures and properties of organic-inorganic hybrid perovskite such as CH3NH3PbI3 material, and subsequently increase the conversion efficiency. In this work, optical absorption is calculated for copper-doped-perovskite material based on the density functional theory analysis for tetragonal crystal structures. We investigated the effect of doping CH3NH3PbI3 with copper, as an optical alternative to Pb atom in central tetragonal structure. As a conclusion, some enhancements of the optical properties by the replacement of Cu by the Pb atom are observed, such as optical absorption at certain visible spectrum regions, along with more intensive field mapping. This optical enhancement can lead to a better improvement of perovskite solar cell according to metallic-doing substitutional defect concept.
Tribological Properties of Additively Manufactured Al-Si Alloys and Steels
Authors: Angolkar Pooja , Manzoor Hussain Mohammed
Published: December 2023

Metals are prone to wear through the separation of wear debris particles as well as the plastic displacement of surface and near-surface material. Particle sizes range from millimetres to nanometres. Erosion is the gradual, layer-by-layer destruction of a metallic object's surface brought on by mechanical pressure or electrical discharges. Metals erode as a result of surface friction, wear, cavitation, and the influence of powerful gas or liquid currents on a surface. Jet engines, nuclear reactors, steam turbines, and boilers might all suffer damage from erosion. By enhancing process technology or unit design, using better materials, and applying heat treatment, it is possible to strengthen the resistance of components against erosion. AlSi10Mg is a hypoeutectic alloy that may be additively manufactured due to its limited solidification range, which reduces hot cracking susceptibility during cooling. Complex bulk and open-cell structures with outstanding strength ratio (strength-to-weight ratio) and good formability may be created using additive manufacturing of aluminium alloys, particularly AlSi10Mg. Carbon, manganese, sulphur, silicon, phosphorus, chromium, nickel, copper, and niobium are all present in the pH grade of 17-4. This combination of high strength and corrosion resistance benefits a 17-4 PH stainless steel grade. It may be utilised effectively in a variety of applications due to its high tensile strength and exceptional corrosion resistance.Powder bed fusion is one of the most mature metal additive methods, and as such, it benefits from decades of industrial expertise. PBF can satisfy demands of creating a new component and need to iterate on ideas quickly or are searching for a more efficient procedure to produce sophisticated components. Material waste is reduced because building the part layer by layer reduces the majority of the waste associated with subtractive manufacturing processes. Any surplus powder is collected and recycled when the item is finished. This review researches about the wear and erosion behaviour of Al-Si Alloy and steels printed using additive manufacturing methods. Finally, the findings of this review are summarised, and recommendations are made for future research aimed at resolving current issues and advancing technology.
Tool Wear and Wear Mechanism of WC-Co End Mill during Milling of CFRP in Sustainable Cutting Conditions
Authors: Halim N.F.H. Abd , Mustafa Aisyah Madihah , Shaharudin N.S. , Dahnel A.N. , Tomadi Siti Haryani , Ahmad Zuraida , Adesta E.Y.T. , Rahman M.M.
Published: December 2023

Carbon Fiber-Reinforced Polymer (CFRP) has been in great demand in the aerospace and automotive industries due to its exceptional strength-to-weight ratio. Machining CFRP is a challenge as dry machining results in high cutting temperature especially with high cutting speeds that compromise the glass transition temperature (Tg) and degrades the matrix resin epoxy. A sustainable cutting environment such as chilled air is utilized as an alternative cutting media in reducing the heat generated during machining process to reduce the tool wear and improved the surface quality of the CFRP. Therefore, this research is conducted to study the progression of uncoated tungsten carbide (WC-Co) tool wear when milling CFRP in a three different cutting conditions which are dry, coolant and chilled air with a constant cutting parameter. The CFRP was milled with a constant speed of 170 m/min, feed rate of 2100 mm/min and 1 mm depth of cut for a total of 6000 mm machining length. It was found that milling in chilled air resulted in the highest flank wear of 0.110 mm, which is higher compared with dry and coolant cutting condition. This is contributed by the additional abrasion of CFRP dust-like chips on the cutting edge of the carbide tool. The presence of the chilled air during milling of CFRP aided in maintaining the surface hardness thus resulted in increasing of tool wear as compared with dry and coolant cutting conditions.
Dual-Band Dual-Polarized Antennas for 5G mmWave Base Stations
Authors: Le Thi H. , Ndip Ivan , Schneider-Ramelow Martin
Published: December 2023

In this paper, we present a systematic approach

for the development of application-specific antennas for 5G

millimeter-wave (mmWave) base stations. First, an in-depth analysis

of 5G mmWave base stations considering the required

antenna gain and antenna elements to address different equivalent

isotropic radiated power requirements is presented. This is

followed by an evaluation of the realistic impact of different factors,

which affect mmWave communication, namely output power

of power amplifiers, antenna gain, losses and weather condition

(rain), on transmission ranges between base station and terminals,

considering the link budget analysis for an Urban Macro cell with

the Non-Line-of-Sight transmission, as an example. Finally, based

on a comparative analysis of published dual-band dual-polarized

5G mmWave antennas, we propose a novel configuration of a

dual-band dual-polarized antenna for 5G mmWave base station

applications, which overcomes the limitations of conventional

antennas in published literature. Our proposed antenna covers

the specified 3GHz bandwidths in the 5G mmWave n257 and

n260 bands and reaches approximately 6 and 6.7 dBi, respectively

in these bands. Furthermore, it exhibits at least 20 dB isolation

between the polarizations and has dimensions of 1.831.83

1.2 mm. We modeled, simulated, fabricated, measured and analyzed

this new antenna configuration. Excellent correlation is

obtained between measurement and simulation results.
A Novel Approach for Characterizing Epoxy Mold Compound High Temperature Swelling
Authors: Chin Ian , Loh Wei Keat , Bin Abdullah Mohd Zulkifly
Published: December 2023

In this paper, a novel method for measuring hightemperature

material swelling of an epoxy mold compound is

explored. This work attempts to extend the swelling characterization

beyond the capability of typical commercial tools. The

approach uses a high-pressure chamber to maintain a saturated

liquid environment for the specimen. Digital image correlation is

used to measure in-situ strain change in the specimen due to

hygro-thermal expansion. The results show moisture-induced

swelling increases with temperature and is significant compared

with thermal expansion. Results are compared against other measurement

methods and published data. This has yielded good fundamental

learnings for the novel concept and identified areas for

future work.
Analisi citomorfologica di fibrina ricca di piastrine liquida prodotta con centrifuga ad angolo fisso DUO (Process, Francia) per l’uso nella terapia rigenerativa delle ulcere cutanee
Authors: Crisci Michela , Lepore Giovanni , Feleppa Federica , Crisci Alessandro , Flagiello Fabiana
Published: December 2023

La fibrina ricca di piastrine (PRF) liquida è un concentrato piastrinico di seconda generazione iniettabile ricco di piastrine, leucociti e fibrinogeno ottenuto per centrifugazione del sangue autologo. Lo scopo di questo studio è analizzare il contenuto cellulare e di fibrinogeno di vari tipi di PRF Liquido (C-PRF liquid, A-PRF liquid, i-PRF, fibrinogeno liquido) ottenuti con l’uso di centrifuga ad angolo fisso DUO (PRF DUO, Process per PRF, Nizza, Francia) con provette Fibrinogeno Liquido (FL) Vacumed (cod. 44909) e/o provetta originale S-PRF Sticky. È stato riscontrato un accumulo medio di Trombociti di quasi 1,5 volte rispetto al sangue intero. A causa dell’elevata concentrazione di Piastrine, i PRF-Liquid contengono importanti fattori di crescita per la rigenerazione tissutale. In questo studio preliminare abbiamo evidenziato che il tipo di PRF Liquido a maggiore contenuto di piastrine (126.3% vs. 109.5%), monociti (127.6% vs. 84.6%), con un sufficiente contenuto di linfociti (192.9% vs. 242.1%) e granulociti neutrofili (64.6% vs. 64.8%) e di fibrinogeno (67.9% vs. 87.3%), è il i-PRF (700 rpm×5 min) ottenuto con provetta Vacumed FL (cod. 44909) con differenze statisticamente non significative rispetto al sangue intero, mentre è maggiore il contenuto di Linfociti e Fibrinogeno presente in i-PRF (700 rpm×5’) ottenuto con provetta PRF-S-Sticky. Molto minore, nel confronto, risulta il contenuto di cellule e fibrinogeno ottenuto con i due metodi di preparazione del PRP. Ciò indica che il PRF liquido più adatto ad essere utilizzato in vari casi di rigenerazione dei tessuti come l’estetica del viso, l’iniezione intrarticolare, l’iniezione periulcerativa, etc. è il i-PRF (700 rpm×5 min) ottenuto con provetta Vacumed FL.
Effetto della tecnica wound hygiene sulla contrazione della lesione: esperienza vulnologia ASL3 Regione Liguria
Authors: Cesura Granara Deborah , Baxa Anna , Viaggi Cinzia , Pruzzo Cristina , Piana Giorgia , Badino Giorgio , Roccaforte Miriam , Pienovi Silvia , Zuliani Tiziana , Marchelli Marco , Perniciaro Giuseppe , Gagliano Carmelo , Bottaro Luigi Carlo
Published: December 2023

Stabilire la effettiva predittività della scala di Braden in terapia intensiva (TI). Studio osservazionale retrospettivo condotto attraverso l’analisi delle cartelle cliniche informatizzate dei pazienti ricoverati in un'unità di TI per tutto il 2019. Pazienti ricoverati nell'unità di TI durante il 2019 che non presentavano ulcere da pressione al momento del ricovero con una degenza ospedaliera di almeno 72 ore. I pazienti che hanno sviluppato lesioni da decubito nelle prime 72 ore sono stati esclusi. Dei 239 pazienti ritenuti idonei allo studio, 230 (96.2%) pazienti avevano un valore della scala di Braden inferiore a 16 ritenuti tutti a “grave rischio di sviluppare lesioni” e solamente 9 (3.7%) pazienti hanno avuto un valore superiore o uguale a 16 considerato come rischio moderato. La Braden ha dimostrato una altissima sensibilità (100%) a scapito di una bassa specificità (4,7%). La scala di Braden calcolata all’ingresso dei pazienti in TI non è in grado da sola di stimare il rischio dello sviluppo di lesioni, a causa della sua bassa specificità che la rende pertanto non idonea all’utilizzo in questo contesto.
Mapping breeding birds in a re-naturalized historical fortress: composition, structure and considerations about abundance vs. biomass comparisons
Authors: Battisti Corrado
Published: December 2023

Using the mapping method, I obtained data about a rich, even and diversified breeding bird assemblage inhabiting an abandoned and re-naturalized historical military fortress (Rome, central Italy). Fortress and the surrounding parks host a large number of edge-mosaic, forest and synanthropic species (often localized at urban scale as Dendrocopos minor and Columba palumbus) due to a large availability of many sub-habitats and related niches (walls, cavities, tree holes, mature trees, mowed meadows, hedgerows, and deep moats). In this regard, this historical site may be considered a “key-stone structure” at the landscape scale (i.e., a mature forest/rocky patch embedded in an agromosaic suburban mosaic). The application of the Abundance/Biomass Comparison (ABC) evidenced a dominant role of large body mass species. The underlying logic behind this approach assumes that, generally, in less disturbed environments species with higher trophic level (and higher body mass) dominate: the increase in frequency of these larger species induce early cumulating biomass curves. However, in our anthropized case study, this assumption seems not valid since many large body mass species (as Columba livia dom., Psittacula krameri and Corvus cornix) show a low trophic level (e.g. granivorous or homnivorous): i.e. body mass is not an indicator of trophic level. Therefore, the pattern reported by ABC curves evidence only a dominance of large body mass species without implications on the trophic level and, consequently, on the disturbance acting on the assemblage. In this regard, assumptions linked to the ABC curves are probably not universal but only limited to specific taxa and contexts.
Hypothalamic circuits and aging: keeping the circadian clock updated
Authors: Vázquez-Lizarraga Rosa , Mendoza-Viveros Lucia , Cid-Castro Carolina , Ruiz-Montoya Sareni , Carreño-Vázquez Erick , Orozco-Solis Ricardo
Published: December 2023

Over the past century, age-related diseases, such as cancer, type-2 diabetes, obesity, and mental illness, have shown a significant increase, negatively impacting overall quality of life. Studies on aged animal models have unveiled a progressive discoordination at multiple regulatory levels, including transcriptional, translational, and post-translational processes, resulting from cellular stress and circadian derangements. The circadian clock emerges as a key regulator, sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes, such as stem-cell function, cellular stress responses, and inter-tissue communication, which become disrupted during aging. Given the crucial role of hypothalamic circuits in regulating organismal physiology, metabolic control, sleep homeostasis, and circadian rhythms, and their dependence on these processes, strategies aimed at enhancing hypothalamic and circadian function, including pharmacological and non-pharmacological approaches, offer systemic benefits for healthy aging. Intranasal brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions, like the hypothalamus, while reducing side effects associated with systemic drug delivery, thereby presenting new therapeutic possibilities for diverse age-related conditions.
Transplantation of human placental chorionic plate-derived mesenchymal stem cells for repair of neurological damage in neonatal hypoxic-ischemic encephalopathy
Authors: Xue Lulu , Du Ruolan , Bi Ning , Xiao Qiuxia , Sun Yifei , Niu Ruize , Tan Yaxin , Chen Li , Liu Jia , Wang Tinghua , Xiong Liulin
Published: December 2023

JOURNAL/nrgr/04.03/01300535-202409000-00035/figure1/v/2024-01-30T062302Z/r/image-tiff

Neonatal hypoxic-ischemic encephalopathy is often associated with permanent cerebral palsy, neurosensory impairments, and cognitive deficits, and there is no effective treatment for complications related to hypoxic-ischemic encephalopathy. The therapeutic potential of human placental chorionic plate-derived mesenchymal stem cells for various diseases has been explored. However, the potential use of human placental chorionic plate-derived mesenchymal stem cells for the treatment of neonatal hypoxic-ischemic encephalopathy has not yet been investigated. In this study, we injected human placental chorionic plate-derived mesenchymal stem cells into the lateral ventricle of a neonatal hypoxic-ischemic encephalopathy rat model and observed significant improvements in both cognitive and motor function. Protein chip analysis showed that interleukin-3 expression was significantly elevated in neonatal hypoxic-ischemic encephalopathy model rats. Following transplantation of human placental chorionic plate-derived mesenchymal stem cells, interleukin-3 expression was downregulated. To further investigate the role of interleukin-3 in neonatal hypoxic-ischemic encephalopathy, we established an in vitro SH-SY5Y cell model of hypoxic-ischemic injury through oxygen-glucose deprivation and silenced interleukin-3 expression using small interfering RNA. We found that the activity and proliferation of SH-SY5Y cells subjected to oxygen-glucose deprivation were further suppressed by interleukin-3 knockdown. Furthermore, interleukin-3 knockout exacerbated neuronal damage and cognitive and motor function impairment in rat models of hypoxic-ischemic encephalopathy. The findings suggest that transplantation of hpcMSCs ameliorated behavioral impairments in a rat model of hypoxic-ischemic encephalopathy, and this effect was mediated by interleukin-3-dependent neurological function.
On implications of somatostatin in diabetic retinopathy
Authors: Fang Yanhong , Wang Qionghua , Li Youjian , Zeng Li , Liu Jian , Ou Kepeng
Published: December 2023

Somatostatin, a naturally produced neuroprotective peptide, depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina. In this review, we summarize the progress of somatostatin treatment of diabetic retinopathy through analysis of relevant studies published from February 2019 to February 2023 extracted from the PubMed and Google Scholar databases. Insufficient neuroprotection, which occurs as a consequence of declined expression or dysregulation of retinal somatostatin in the very early stages of diabetic retinopathy, triggers retinal neurovascular unit impairment and microvascular damage. Somatostatin replacement is a promising treatment for retinal neurodegeneration in diabetic retinopathy. Numerous pre-clinical and clinical trials of somatostatin analog treatment for early diabetic retinopathy have been initiated. In one such trial (EUROCONDOR), topical administration of somatostatin was found to exert neuroprotective effects in patients with pre-existing retinal neurodysfunction, but had no impact on the onset of diabetic retinopathy. Overall, we concluded that somatostatin restoration may be especially beneficial for the growing population of patients with early-stage retinopathy. In order to achieve early prevention of diabetic retinopathy initiation, and thereby salvage visual function before the appearance of moderate non-proliferative diabetic retinopathy, several issues need to be addressed. These include the needs to: a) update and standardize the retinal screening scheme to incorporate the detection of early neurodegeneration, b) identify patient subgroups who would benefit from somatostatin analog supplementation, c) elucidate the interactions of somatostatin, particularly exogenously-delivered somatostatin analogs, with other retinal peptides in the context of hyperglycemia, and d) design safe, feasible, low cost, and effective administration routes.
Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?
Authors: Carrero Laura , Antequera Desireé , Municio Cristina , Carro Eva
Published: December 2023

Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's disease. A predominant function of the retina is circadian synchronization, carrying information to the brain through the retinohypothalamic tract, which projects to the suprachiasmatic nucleus. Notably, Alzheimer's disease hallmarks, including amyloid-β, are present in the retinas of Alzheimer's disease patients, followed/associated by structural and functional disturbances. However, the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer's disease is not fully understood, although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm.
Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice
Authors: Aguado Carolina , Badesso Sara , Martínez-Hernández José , Martín-Belmonte Alejandro , Alfaro-Ruiz Rocío , Fernández Miriam , Moreno-Martínez Ana Esther , Cuadrado-Tejedor Mar , García-Osta Ana , Luján Rafael
Published: December 2023

JOURNAL/nrgr/04.03/01300535-202409000-00040/figure1/v/2024-01-30T062302Z/r/image-tiff

Plaques of amyloid-β (Aβ) and neurofibrillary tangles are the main pathological characteristics of Alzheimer's disease (AD). However, some older adult people with AD pathological hallmarks can retain cognitive function. Unraveling the factors that lead to this cognitive resilience to AD offers promising prospects for identifying new therapeutic targets. Our hypothesis focuses on the contribution of resilience to changes in excitatory synapses at the structural and molecular levels, which may underlie healthy cognitive performance in aged AD animals. Utilizing the Morris Water Maze test, we selected resilient (asymptomatic) and cognitively impaired aged Tg2576 mice. While the enzyme-linked immunosorbent assay showed similar levels of Aβ42 in both experimental groups, western blot analysis revealed differences in tau pathology in the pre-synaptic supernatant fraction. To further investigate the density of synapses in the hippocampus of 16–18 month-old Tg2576 mice, we employed stereological and electron microscopic methods. Our findings indicated a decrease in the density of excitatory synapses in the stratum radiatum of the hippocampal CA1 in cognitively impaired Tg2576 mice compared with age-matched resilient Tg2576 and non-transgenic controls. Intriguingly, through quantitative immunoelectron microscopy in the hippocampus of impaired and resilient Tg2576 transgenic AD mice, we uncovered differences in the subcellular localization of glutamate receptors. Specifically, the density of GluA1, GluA2/3, and mGlu5 in spines and dendritic shafts of CA1 pyramidal cells in impaired Tg2576 mice was significantly reduced compared with age-matched resilient Tg2576 and non-transgenic controls. Notably, the density of GluA2/3 in resilient Tg2576 mice was significantly increased in spines but not in dendritic shafts compared with impaired Tg2576 and non-transgenic mice. These subcellular findings strongly support the hypothesis that dendritic spine plasticity and synaptic machinery in the hippocampus play crucial roles in the mechanisms of cognitive resilience in Tg2576 mice.
Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings
Authors: Serra Marcello , Simola Nicola , Pollack Alexia E. , Costa Giulia
Published: December 2023

Preclinical and clinical studies indicate that psychostimulants, in addition to having abuse potential, may elicit brain dysfunctions and/or neurotoxic effects. Central toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and adults. The present review provides an overview of recent research, conducted between 2018 and 2023, focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine, cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine, methylphenidate, caffeine, and nicotine. Detailed elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes.
Ultrasound-Guided Combined Greater Occipital Nerve Block at the C2 Level with Trapezius Trigger Point Injection and Supraorbital-Supratrochlear Nerve Block: More Effective on Allodynia and Disability in Chronic Migraine
Authors: Turan Suna Aşkın , Aydın Şenay , Gözükara Melih G. , Çabalar Murat
Published: December 2023

Background:

Chronic migraine (CM) patients with cutaneous allodynia (CA) show a poor response to treatment. Long-term studies have yet to be conducted to demonstrate the efficacy of blocks on CA. This study evaluated the improvement in allodynia and disability in CM treated with ultrasound (US)-guided blocks.

Methods:

In this prospective, non-randomized comparative study, 60 CM patients with CA were evaluated for the clinical effectiveness of the therapy using the numeric rating scale (NRS), headache impact test-6 (HIT-6), brush allodynia test, and allodynia symptom checklist (ASC-12). At the first visit, tenderness in the nerve or trapezius muscle was confirmed in the intervention group. US-guided greater occipital nerve block (GONB), GONB, and trapezius muscle injection (TPI), or GONB, TPI, and peripheral trigeminal nerve block (PTNB), respectively, were performed four times once a week for a month. Initial and third-month assessments were performed.

Results:

The ASC-12 scores decreased in the GONB+TPI+PTNB and GONB groups more than the GONB+TPI group (mean rank, respectively, 26.86, 27.40, 38.39; P = 0.018). The decrease in HIT-6 scores was greater in the GONB+TPI+PTNB group than in the GONB group (mean rank, respectively, 21.98, 39.95, P < 0.017) in the first month. In the third month, the GONB+TPI+PTNB group scored HIT-6 significantly lower than GONB and GONB+TPI (mean rank: 18.84, 38.73, 35.61; P < 0.001).

Conclusions:

GONB+TPI+PTNB was more successful in alleviating allodynia and disability.
Immunohistochemical study of proline, glutamic acid and leucine-rich protein 1 (PELP1) in correlation with guanine adenine thymine adenine family member 3 (GATA-3) receptors expression in breast carcinomas
Authors: Elmetwally Ahmed A , Abdel-Hafeez Mennat Allah M , Hammam Makram M , Hafez Gamal A , Atwa Maha M , El-Kherbetawy Mohammed K
Published: December 2023

Background

Breast cancer is the most common cancer affecting Egyptian women. Guanine adenine thymine adenine family member 3 (GATA-3) and Proline, glutamic acid and leucine-rich protein 1 (PELP1) are both expressed in breast carcinomas.

Aim

To evaluate GATA-3 and PELP1 proteins expression in breast carcinoma, assess association of both immunohistochemical markers with variable prognostic factors, correlate between GATA-3 and PELP1 expression and assess the diagnostic utility of both markers in breast carcinomas.

Subjects and methods

The current study was a cross-sectional descriptive study, performed in the Pathology laboratory of Suez Canal University Hospital on 86 samples of formalin fixed paraffin embedded blocks of breast carcinoma during the period from January 2016 to May 2019.

Results

GATA-3 and PELP1 showed positive nuclear expression in breast carcinoma cases (74.4% and 82.6%, respectively). PELP1 expression showed statistically significant association with older age cases. GATA-3 expression showed statistically significant association with positive ER, PR and HER-2 expression and molecular subtypes. A statistically significant correlation was found between GATA-3 and PELP1 expression in breast carcinomas (n=86, P value <0.05). PELP1 showed the highest sensitivity in stage III breast cancer samples (84.9%) compared to GATA-3 (75.8%), ER (66.7%), PR (54.6%) and HER2 (39.4%). PELP1 is more sensitive (80%) than GATA-3 (60%) in grade III breast carcinomas. GATA-3 is more sensitive (89.7%) than PELP1 (86.2%) in luminal breast cancer subtype. the combined parallel use of GATA-3 and PELP1 raised their sensitivity to 92% in Grade III and 98.6% in luminal breast cancers.

Conclusions

GATA-3 and PELP1 may be a promising diagnostic markers of breast carcinoma. Further studies are needed to fully evaluate the prognostic significance of GATA-3 and PELP1 expression in invasive breast carcinomas.
Prognostic value of hyaluronidase-1 and CD44 immunohistological expression in gastric cancer
Authors: Aboushoush Tarek , Kamel Amira , Montasser Ahmed , Ibrahim Ahmed , Khalil Heba
Published: December 2023

Introduction

Although many studies have investigated molecular markers for gastric cancer, the mechanisms of carcinogenesis remain obscure. CD44 serves as the principal transmembrane hyaluronate receptor. HAS1 has been identified as a key contributor to oncogenesis and disease progression in both hematological and solid cancers HAS1 has been shown to be prognostic factor in a variety of other cancers.

Aim

Our aim was to evaluate the expression of the CD44 and HAS1 as prognostic indicators for gastric cancer.

Methodology

Seventy five cases of gastritis and gastric cancer, obtained from the archives of Pathology Departments of Theodor Bilharz Research Institute (TBRI) – Giza, Egypt, including eleven case with gastritis and sixty four cases of gastric cancer. Detailed histopathological assessment was done as well as immunohistochemical staining for CD44 and HAS1.

Results

Our results showed increased expression of both HAS1 &CD44 with increasing grades and stages as well lymph node metastasis of gastric carcinoma. No significant difference was noticed in their expression between H.pylori associated and non-associated gastritis.

Conclusion

We concluded that modulation of HAS1/ CD44 expression is of significant prognostic value in gastric cancer and could be a major target for the anticancer and chemo-preventive agents.
Nickel Alloy, Corrosion- and Heat-Resistant, Bars, Forgings, Rings and Stock for Forging 41.5Ni - 16Cr - 37Fe - 2.9Cb (Nb) - 1.8Ti Consumable Electrode Remelted or Vacuum Induction Melted 1750 °F (954 °C) Solution Heat Treated
Authors:   AMS F Corrosion and Heat Resistant Alloys Committee
Published: December 2023

This specification covers a corrosion- and heat-resistant nickel alloy in the form of bars, forgings, and flash-welded rings up to 4.00 inches (101.6 mm), inclusive, in nominal thickness or distance between parallel sides and having a maximum cross-sectional area of less than 12.6 square inches (81 cm2). Stock for forging or flash-welded rings may be of any size and condition as ordered.
Standard Practice for Human Systems Integration
Authors:   G-45 Human Systems Integration
Published: December 2023

This SAE Standard identifies contractor activities for planning and conducting HSI as part of procurement activities on Department of Defense (DoD) system acquisition programs. This standard covers HSI processes throughout system design, development, test, production, use, and disposal. Depending on contract phase, type of the program and/or complexity of the program, tailoring of this standard should be applied. Appendix A lists the requrememts (“shall” statements) in this standard along with unique numbers to facilitate tailoring. In addition, Appendix D provides tailoring guidance to better match requirememts in this standard to the DoD’s Adaptive Acquisition Framework pathways. The scope of this standard includes prime and subcontractor HSI activities; it does not include Government HSI activities, which are covered by DoD and service-level regulations and guidelines. HSI programs should use the latest version of standards and handbooks listed below, unless a particular revision is specifically cited in the contract.
Culpabilidade sem retribuição
Authors: Greco Luís
Published: December 2023

Based on Claus Roxin’s reflections on the concept of culpability in Criminal Law and its dissociation from the theory of retribution, this study aims to outline considerations for the discussion on the recognition of culpability without punishment. After showing how retributivists and social defence theorists arrive at a dilemma regarding the need to impose deserved punishment, the solution developed by Roxin, which allows for the refusal of punishment even when culpability is established, is presented: the state action of imposing punishment must be justified, on the one hand, not in a retributive way, but by preventive purposes, and, on the other hand, limited – and not grounded – by the principle of culpability (which does not have a retributive character; hence the unilateral view of the principle of culpability). Finally, the political-criminal and dogmatic consequences of Roxin’s position are examined, and the reception of the thesis as well as the criticism addressed against it are analysed
La Iglesia ante el reto de las nuevas culturas
Authors: González-Carvajal Santabárbara Luis
Published: December 2023

Lo que la sociedad contemporánea necesita es integrar la mayor parte de lo que hasta ahora ha sido excluido, ignorado o despreciado. Utilizando la terminología hegeliana podemos decir que el Modernismo formuló una tesis que pretendía ser verdadera. Esa fue la fase afirmativa, que que, sin embargo, era sólo parcial. En consecuencia surgió una antítesis, la que se denomina Postmodernismo. Esta es la fase negativa, que se ha revelado también incompleta. Ahora nos vemos obligados a buscar una síntesis de las dos fases anteriores, la verdad en un nivel superior
Prólogo: Perspectivas de la Investigación. Explorando las complejidades de América Latina a través de estudios de caso
Authors: Vargas Johana , Simbaña Q. Roberto
Published: December 2023

Prólogo: Perspectivas de la Investigación. Explorando las complejidades de América Latina a través de estudios de caso
Análisis de las estrategias de la deserción universitaria en el contexto de la pandemia COVID-19
Authors: Urías Rivas María Oralia , Lugo Hernández Lourdes Teresa , Rivera Obregón Mónica Liliana , López López María Lourdes
Published: December 2023

Esta investigación se enfocó en comprender el impacto del COVID-19 en la deserción estudiantil dentro de la Facultad de Ciencias Económicas y Administrativas, Extensión Sinaloa Leyva, de la Universidad Autónoma de Sinaloa. Se utilizó el procedimiento mixto, para alcanzar una perspectiva completa del problema. La información se recolectó a través de cuestionarios y entrevistas para explorar las experiencias y percepciones de los estudiantes afectados. Los hallazgos revelaron que el COVID-19 registró un impacto significativo en la deserción estudiantil, afectando la participación académica y generando preocupaciones emocionales y económicas entre los estudiantes. En conclusión, la repentina transición de un sistema educativo tradicional a un entorno digital, durante la pandemia, generó desafíos relevantes para algunos alumnos, obstaculizando la capacidad para continuar con los estudios por la falta de acceso tecnológico y la conexión a internet, generando altos niveles de estrés y ansiedad.
El cliente electoral en tiempos de sufragio
Authors: Bambaren Mata Luis Alberto , Silva Huamantumba Edman Junior , Rivero Lazo Mélida Sara , Simón Verástegui Edgar
Published: December 2023

En un contexto de elecciones dónde se procede a elegir a nuestras autoridades, se presentan un sin número de actores en el que, dentro del mercado electoral, vamos a encontrar y evaluar a cada uno de estos, entre ellos se encuentran los clientes electorales que forma la agrupación de los ciudadanos que tienen el derecho de elegir a sus autoridades. Por una forma didáctica y técnica lo vamos a subdividir en consumidor electoral; siendo aquellos electores que escogen con mayor criterio y raciocinio a sus candidatos o lista de candidatos al momento de sufragar. Mientras que en el otro sub-cliente encontramos al comprador electoral, por ser aquellos votantes, que realizan el acto de colocar la cédula de sufragio en el ánfora sin mayor criterio de elección y que tienen como conducta operativa el proceso electoral.