bluuebunny/crossref_metadata_2025 huggingface dataset:
Two editions of Sny i kamienie by Magdalena Tulli
Authors: Wąsowski Piotr Jakub
Published: October 2022

The author offers a juxtaposition of two editions of Sny i kamienie [Dreams and Stones] by Magdalena Tulli in the context of Italo Calvino’s Invisible Cities and urbanology. In the text he analyses the differences between the editions and discusses the origins of the modifications of the novel implemented by the writer. Those modifications sometimes facilitate while other times hinder the identification of the sources of her thinking, i.e., her reflection on urbanity. Sny i kamienie is a novel that constitutes a record of the experiences of the modernist transformation of two cities, Warsaw and Milan. The reading of Sny i kamienie is difficult at several levels: firstly, due to its treatise-like style and the narrator’s role of a seemingly uncritical eulogist of the urban planning order; secondly, due to a blurring of the traces of contaminations of various experiences: of Warsaw, of Milan, and that of a reader; and thirdly, due to a lack in Polish culture of any traditions of this type of prose text devoted to the city. The essay constitutes an attempt at reconstructing the possible contexts of the novel and how they influenced the alterations implemented by the writer in the more recent edition.
«Летучий голландец» белорусской поэзии: сборник Нэа-літ как литературный феномен
Authors: Levytskyi Viacheslav
Published: October 2022

Цель предлагаемой работы – проанализировать статус сборника Неалит (1993–1994) в белорусском литературном процессе 1990-х гг. Материал исследования составляет макет этой книги из личного архива поэта Виктора Жибуля. Ранее соответствующий документ не был обнародован и введен в научный оборот.
Особенности Нэа-літа освещаются в обще концептуальном, текстологическом и жанрово-стилистическом аспектах.
Среди прочего, мини-антология продемонстрировала кристаллизацию новой литературы. Кроме того, в сборник вошли варианты стихотворений Сержа Минскевича, Ильи Сина, Алеся Туровича, отличные от более поздних публикаций. В итоге Нэа-літ стал площадкой для поиска актуального художественного языка. В рамках макета издания наметились радикальные транслогические эксперименты, сформировался нестандартный жанр «панфиль», проявилось преобладание образов городского пространства с подчеркнутыми мотивами телесности.
Theories of Change for WFP Afghanistan’s Contribution to the Triple Nexus: Final Report
Authors: Sida Lewis , Nelis Tina
Published: October 2022

Prior to the Taliban takeover in August 2021, the World Food Programme (WFP) Afghanistan had been working to see how its strategic outcomes in the 2018–23 Country Strategic Plan (CSP) were aligned with viable peace and development efforts nationally, and to investigate plausible pathways by which its interventions could support broader goals to contribute to the humanitarian–development–peace (triple) nexus. With the Taliban regaining control, these pathways have become less clear and difficult for WFP to make firm strategies. This Theory of Change (TOC) document looks at each of the relevant strategic outcomes from the 2018 CSP in turn (temporarily rolled over as a result of the uncertainty) and proposes theoretical ways in which the interventions can be best aligned with medium- to longer-term goals. Whilst these can no longer be simplistically labelled ‘development’ and ‘peace’, preserving national systems and institutions remains vitally important to ensure minimum humanitarian suffering. The aim of developing these TOCs is to help best align current programming and develop future programming options, as well as better generating evidence on what works. The TOCs are also intended to be a bridge to the next CSP, generating evidence to inform future strategic outcomes and helping the organisation think through realistic contributions to national systems.
Química analítica básica
Authors: Andrade João Carlos de
Published: October 2022

A gravimetria convencional, também conhecida como gravimetria de precipitação, consiste em uma sequência de operações que tem como objetivo precipitar (separar) a substância de interesse (o analito) na forma de um composto pouco solúvel, com estequiometria conhecida e bem definida. Após sua separação e secagem, o precipitado é pesado ​​em uma balança analítica e, a partir da sua massa e estequiometria, a concentração do analito original é quantitativamente determinada. É um método de análise em que o sinal medido é a massa ou a variação de massa e sua aplicação requer apenas o uso de unidades básicas do Sistema Internacional de Unidades (SI), como a massa ou o mol. Dentre as vantagens no emprego desta técnica estão a sua boa reprodutibilidade, associada à simplicidade de execução operacional e ao emprego de equipamentos de uso comum em laboratório. Por outro lado, suas principais desvantagens residem no seu tempo de execução, geralmente muito longo e na falta de sensibilidade do método, que o torna impraticável na determinação de microconstituintes da amostra. Apesar de estar sujeita a erros acumulativos, provocados por possíveis falhas de execução nas várias etapas, operações e manipulações necessárias à sua execução, os resultados obtidos com a utilização de métodos gravimétricos são bastante precisos, limitados apenas pelo limite de detecção da balança analítica usada no procedimento. É a técnica de análise quantitativa mais antiga e, embora não seja atualmente o método analítico mais importante, continua ainda sendo usado em aplicações especializadas e na padronização processos.
A arte “do” e “no” rio
Authors: Castro José Guilherme de Oliveira , Teixeira Lucilinda Ribeiro , Teixeira Will Montenegro
Published: October 2022

Este ensaio é resultado de pesquisa de campo realizada entre os anos de 2017 e 2020 na Ilha do Combu, uma das 39 ilhas que compõem a parte insular da capital Belém, na Amazônia paraense. O objetivo da pesquisa foi analisar a relação de moradores e artistas a partir de suas relações representativas e estéticas dos graffitis, com o foco na produção de sentido e na construção de significados. As manifestações artistas integram o projeto Street River, idealizado pelo artista visual Sebá Tapajós, com a participação de diversos artistas, entre nacionais e internacionais.
Carreirinho – entre arranca, marca e volta de mal(bem)dito do não quisto
Authors: Negretti Natalia , Araujo Morgana Caroline Lima
Published: October 2022

Em 2017 um lambe num complexo de centros de acolhida na cidade de São Paulo que dizia “A praga é o asfalto. Erva daninha é resistência” foi motivo de um registro fotográfico...
Apresentação
Authors: Saldanha Inácio dos Santos , Augusto Isabela Cassis , Silva Analice Paron de , Vicentin Letícia
Published: October 2022

Temos o prazer de apresentar mais uma edição do Prêmio Mariza Corrêa de Antropologia Visual 2021. A premiação é uma iniciativa dos alunos do Programa de Pós-Graduação em Antropologia Social (PPGAS) da Unicamp, em uma parceria entre dois projetos do corpo discente do programa que é realizada desde 2017: As Jornadas de Antropologia John Monteiro e a Proa: Revista de Antropologia e Arte. As Jornadas, agora em sua décima edição, são um evento realizado anualmente pelos alunos ingressantes do PPGAS desde o ano de 2011, que tem promovido a comunicação entre as pesquisas de estudantes de diversas instituições, debates sobre a história e os novos horizontes da antropologia, com atenção para temas sociais e suas implicações éticas, teóricas e metodológicas para o ofício antropológico. A Proa, por sua vez, é uma revista científica de periodicidade semestral e formato digital que foi criada por discentes do PPGAS em 2009. Tem se empenhado na publicação e nos debates da antropologia visual, mas também das interfaces entre antropologia e arte e da história da antropologia no Brasil e, em especial, na Unicamp.
Lendas dos índios Tembé (Pará e Maranhão)
Authors: Unkel Curt Nimuendajú , Azevedo Adriana Maria Huber
Published: October 2022

Tradução de: UNKEL, Curt Nimuendajú. Sagen der Tembé-Indianer (Pará und Maranhão). Zeitschrift für Ethnologie, Berlim, v. 47, n. 4/5, p. 281–305, 1915. Domínio público.
Beneficial effects of bunch-zone late defoliations and shoot positioning on berry composition and colour components of wines undergoing aging in an organically-managed and rainfed Sangiovese vineyard
Authors: Tessarin Paola , Ricci Arianna , Baraldi Gabriele , Lombini Alessandra , Parpinello Giuseppina P. , Rombolà Adamo Domenico
Published: October 2022

In the context of climate change, where high temperatures are frequent in the first phases of ripening, protecting grapevine bunches from solar radiation is essential for preserving berry composition and wine colour. The effects of bunch-zone late defoliations (DEFs) and “semi-ballerina” shoot positioning (SB) on vine physiology and grape and wine quality of organic cv. Sangiovese wines during storage were assessed in two contrasting seasons (2013 and 2014). The treatments altered neither vine physiology (leaf photosynthetic activity and stomatal conductance, stem water potential) nor vine phenology, yield, budburst and fruitfulness. Defoliations imposed at post-veraison (DEF I) and pre-harvest (DEF II), but not shoot positioning imposed at post-veraison, enhanced the concentration of berry skin flavonols at harvest, compared to an untreated control. Late defoliations and SB did not change berry weight, anthocyanins, soluble solids, pH or titratable acidity at harvest.
The severity of Botrytis bunch rot was assessed in both seasons. In 2013, it was negligible regardless of the treatment.
In 2014 (characterised by higher rainfall and lower average temperatures than in 2013), late defoliations (DEF I and DEF II), especially DEF I, and SB to a minor extent, limited the severity of Botrytis bunch rot. The oenological benefits of late defoliations and shoot positioning were observed during wine storage. These canopy management practices positively influenced wine components (polymeric pigments; namely short polymeric pigments) that might have a marked effect on the final colour intensity, without altering the basic chemical characteristics of the wine. When choosing the timing for carrying out defoliation in order to improve grape quality and bunch rot containment, the meteorological conditions should be properly considered. Our results may contribute to providing further recommendations for canopy management for grape growers who produce organic Sangiovese wines that undergo aging.
Role of Patient's Ethnicity in Seeking Preventive Dental Services at the Community Health Centers of South-Central Texas: A Cross-Sectional Study
Authors: Shelke Girish Suresh , Marwaha Rochisha Singh , Shah Pankil , Challa Suman N.
Published: October 2022

Abstract: Background: To determine the impact of a patient's ethnicity on the seeking preventive dental services at the Community Health Centers (CHCs) in South-Central Texas. Methods: Pri-mary electronic health records (HER) data were collected regarding each patient's medical and dental history, and comprehensive treatment planning. The researchers retrieved EHR from Jan-uary 2016 to 2022. Bivariate analysis was completed to test outcome with predicator and covariates using appropriate statistical tests. A multiple linear regression model was used to understand the association between the predictor and outcome variable while controlling for confounders. Results: The study findings revealed significantly higher dental visits (2.26 ± 2.88) for Hispanic patients. The results from the multiple regression model indicated that non-Hispanic patients had a 8% fewer chance of visiting the CHCs for preventive dental services compared to the Hispanic population (p-value<0.001) when all other variables are held constant. However, the study results were not significant as the effect size was small to conclude the effect of ethnicity on the patients visiting the dental clinic at the CHCs for preventive services. Conclusion: The study concluded that there is no difference in the preventive dental services completed by Hispanics and Non-Hispanics when all other variables are controlled.
Approaches to Enhancing Bioproduction using Lignocellulose Biomass: A Major Focus on Biofuel Production
Authors: Ugwuoji Emmanuel , Eruala Levi , Akpadolu Chidinma , Akpadolu Kenechi
Published: October 2022

The demand for an efficient utilization of abundant biomasses is growing for the production of biogas and valuable bioproducts. Lignocellulose biomass is a cheap and most abundant carbon source for the production of biofuels such as bioethanol, biobutanediol, and other bio-based chemicals. Due to its complex heterogeneity, its hydrolysis gives rise to a mixture of sugars, mainly glucose; a hexose and xylose; a pentose. Glucose is the most abundant carbohydrate monomer. Most microorganisms have evolved the ability to utilize it preferably due to carbon catabolite repression regulatory mechanism at the detriment of the pentoses. Some microbes even lack the ability to utilize them. This has led to the sequential use of these sugars and accompanying reduced productivity due to inadequate utilization of the pentoses. Also, this sequential utilization of the sugars takes time and makes the overall processes economically costly. Since lignocellulose hydrolysates comprise both hexoses and pentoses, the catabolism of these sugar mixtures to biofuels will require an efficient microbial strain capable of simultaneous utilization. The use of CCR negative mutants can achieve this. CCR negative mutants simultaneously utilize pentoses and hexoses, ensuring an improved fermentation efficacy and greater productivity, thus, making the overall bioprocess economically feasible. This article reviewed several approaches employed in creating these mutant microorganisms. A brief insight on carbon catabolite repression and phosphostransferase system were made. It also highlighted the biogas production processes, factors affecting anaerobic digestion, lignocellulosic biomass structure, challenges with their use and solutions to overcoming the challenges.
Pengaruh Lingkungan Kerja, Motivasi dan Efikasi Diri Terhadap Kinerja Karyawan Pada CV. Pesona Sakti Bangkalan Di Masa Pandemi Covid-19
Authors: Rosid Abd. , Irawati S Anugrahini
Published: October 2022

CV. Pesona Sakti is a company in construction services. It has a very tight competition, CV. Pesona Sakti has had commitment and powerd by improving the employees performance. This study analyzes the effect of the work environment, motivation, and selfefficacy on employees performance during the covid-19 pandemic. The independent variables are work environment, motivation and self-efficacy and the dependent variable is employees performance. The data collection method uses a questionnaires and the data analyzes using multiple linear regression. The results indicate that the work environment has a  positive and significant effect on the employees performance with a value is 2.517 and the significance value is 0.015 0.05. Motivation has a positive and significant effect on the employees performance with a value is 4.120 and the significance value ois 0.000 0.05. Self-efficacy has a positive and significant effect on employees performance with a value is 2.109 and the significance value is 0.040 0.05. Simultaneously, the work environment, motivation, and self-efficacy have a positive and significant effect on the employees performance with a value is 44,4692.81 and the significance value is 0.0000.05.
Ética radical para el psicoanalista de hoy
Authors: Orange Donna
Published: October 2022

Radical ethics refers to the obligation we always have to our neighbor, that is, to the stranger/other, my brother or sister. In this work I review my reading of the task of the clinician and psychoanalyst, as a professional and as a human being and the commitment it implies for the development of their work. To do this I review the thought of a Danish philosopher, Knud Ejler Løgstrup, in line with the thought of the Lithuanian Emmanuel Levinas, influenced by Heidegger, on the demand that weighs on the human being.
Epistemología relacional y psicoanálisis. Principales supuestos
Authors: Rodríguez Sutil Carlos
Published: October 2022

The idea that our mind is isolated in an inner space, "inside our heads," is deeply rooted in our culture. From the relational perspective in psychoanalysis we maintain, instead, that the mind is not something innate or internal, but is a product of human interaction, within a particular way of life. The metaphysical counterpart of the egocentric perspective is the problem of other minds – how can I be sure of the existence of minds other than my own? We should urgently review the concept of "internal representation", and its derivatives, such as the "internal object", probably also that of "object of the self", internalization and many others. Relational psychoanalysis, within the great variety of existing proposals, puts the origin of the psyche in the group, starting with the family group, departs from the energetic metapsychology but does not accept an exclusively hermeneutic version, but pays special attention to the evolutionary trauma and the attributions and family myths at the origin of the pathology.
La terapia sexual relacional. Reflexiones sobre el abordaje de la sexualidad adulta en la consulta del psicoterapeuta. Resultados del Estudio-Sex
Authors: Gallego Ricardo , Castaño Rosario
Published: October 2022

The importance of adult sexuality in society and in our daily lives is undeniable and even more so when difficulties appear that make it difficult for us to enjoy it and make us suffer. We suspect, based on our clinical experience and our own data (EPIFEAP study), that in the consultations of the psychotherapists with whom we collaborate, the demands of the patients do not include these sexual dysfunctions very often. In this article we ask ourselves some questions in this sense and we use the data from the Estudio_Sex to reflect and elaborate some answers and hypotheses. We also explain the type of sexual psychotherapy we use in our practice.
Distribución de especies cinegéticas en los espacios adehesados de Extremadura: comparativa entre el siglo XVIII y los cotos de caza mayor actuales
Authors: Rengifo Gallego Juan Ignacio , Martín Delgado Luz María , Sánchez Martín José Manuel
Published: October 2022

Durante el siglo XVIII la caza mayor era una práctica reservada a las clases sociales dominantes, por razones de prestigio y distinción frente al resto de personas. No obstante, este modelo cinegético compartía protagonismo con otros tipos de caza en los que se perseguían fines diferentes. Bajo estas premisas, el objetivo de este trabajo es doble. Por una parte, analizar la distribución territorial de las especies de caza mayor a finales del siglo XVIII, basándose en los datos aportados por una fuente histórica de gran alcance, (Interrogatorio de la Real Audiencia de Extremadura de 1792) y, por otra parte, establecer una comparación con la actual distribución de los cotos de caza mayor situados sobre espacios adehesados. El material utilizado procede del Interrogatorio de la Real Audiencia de Extremadura de 1792, compuesto de 10 tomos. En concreto, se han usado las respuestas dadas a la pregunta 57, con cuya información se construyó una base de datos, se hizo un análisis semántico y se implementó la información en un proyecto SIG. Los resultados muestran que, en términos comparativos con la realidad actual, se confirma que las especies de caza mayor ocupan el mismo territorio, existiendo una alta coincidencia con extensas zonas adehesadas de Extremadura.
High-throughput image-based drug screening of Caenorhabditis elegans movement, development, and viability
Authors: Gallo Kendra , Zamanian Mostafa
Published: October 2022

Caenorhabdtis elegans is an important model organism for identifying and studying druggable targets in a high-throughput manner [1–3]. We have previously described a modular pipeline for image processing and analysis for both parasitic and free-living worms [4]. Here, we detail the upstream assay set up for high throughput drug screens of the free-living nematode C. elegans.
Following a standard bleaching protocol, embryos are hatched overnight and synchronized L1s are added to a 96-well plate. Concentrated Esherichia coli strain HB101 bacterial food [5] is added to each well to sustain growth for 48 hours along with compounds of interest. Plates are incubated for 48 hours until worms reach the young adult stage. While this assay has been optimized for image acquisition with an ImageXpress high-content imager, it can be adapted for use on similar imaging platforms. Analysis of images from an ImageXpress is seamless using wrmXpress [4], but other analysis software can be used.
Pesudo-capsulated Hepatocellular Carcinoma: Hepatic Arterial Infusion Chemotherapy versus Transcatheter Arteial Chemoembolization
Authors: An Chao , Yao Wang , Zuo Mengxuan , Li Wang , Chen Qifeng , Wu Peihong
Published: October 2022

Background
The effectiveness and safety of hepatic arterial infusion chemotherapy (HAIC) or trans-arterial chemoembolization (TACE) for cases with single pseudo-capsuled hepatocellular carcinoma (pHCC), as well as their survival outcomes were investigated.
Methods
196 cases with single pHCC (diameter > 5 cm) receiving initial HAIC (n = 92) and TACE (n = 104) were enrolled. The propensity score match (PSM) approach based on Cox models was employed to tune any possible imbalance in treatment assignment. The overall survival (OS), objective response rate (ORR), progression-free survival (PFS), and partial response rate (PRR) of the subjects were investigated by using the Log-rank test. The independent risk factors for outcomes were investigated by univariate and multivariate analyses and the results were analyzed by using the Cox regression model.
Results
The median follow-up of the subjects was 22.3 months. After PSM, no significant difference was found in OS of the HAIC and TACE groups (OS, 16.8 vs. 12.0 months; P = 0.267), while the median PFS of the TACE group was enhanced compared with the HAIC group (PFS, 5.7 vs. 2.8 months; P = 0.003). Moreover, PRR and ORR of the TACE group were enhanced compared with the HAIC group (PRR, 34.6% vs. 21.7%; P = 0.046; ORR, 35.6% vs. 21.7%; P = 0.033). The nomogram model showed high predictive accuracy and significant discrimination.
Conclusions
TACE therapy could improve the control of tumor progression compared with HAIC for cases with single pHCC.
Dissecting the novel molecular interactions of solute carrier family 4 member 4 (SLC4A4) for prostate cancer (PCa) progression
Authors: Rashid Asif , Fung Hiu Ling , Tang Alexander Hin Ning
Published: October 2022

Prostate cancer (PCa) is the most common malignancy diagnosed in men. The purpose of this study was to report the mechanistic pathways of SLC4A4 in the progression of PCa. Here, we report our findings from clinical specimens of prostatic acinar adenocarcinoma collected from patients. We found that low grade prostate cancers have higher SLC4A4 expression compared to high grade cancers. We investigate the role of SLC4A4 and the signaling mechanism underlying its role in modulating the PCa progression. We report the SLC4A4/RB axis, which acts to drive the cell proliferation. SLC4A4 knockdown decreases the interaction between these molecules with hypophosphorylation of RB protein and cell cycle arrest. We also investigate the SLC4A4/GSK-3β/β-catenin signaling axis which regulates the clonogenic potential, invasiveness and metastasis. Functional analysis reveals that SLC4A4 knockdown retards tumor growth and lower the invasion and migration potential. This is related to relieve of the GSK-3β activity, which phosphorylates β-catenin at Ser33/37 with reduction of β-catenin level in PCa cells. Likewise, transcriptome sequencing using the SLC4A4 knockdown in DU145 shows regulation of differentiated expressed genes and multiple metabolic pathways. Our results suggest that SLC4A4 may serve as a potential therapeutic target for prostate cancer patients in the future.
Partial-convolution-implemented generative adversarial network (GAN) for global oceanic data assimilation
Authors: Ham Yoo-Geun , Joo Yong-Sik , Kim Jeong-Hwan , Kim Kang-Min , Lee Jeong-Gil
Published: October 2022

The oceanic data assimilation (DA) system, which interpolates the sparse observations to regular grids based on physical knowledge implemented in a numerical model, is indispensable to understand and forecast the global oceanic climate variabilities. Here we developed a deep-learning-based global oceanic DA system—DeepDA—by incorporating a partial convolutional neural network and a generative adversarial network (GAN). The partial convolution acts as an observation operator that projects the irregular observational information on gridded fields, and the GAN model brings in the observational information from previous time frames. Observing system simulation experiments showed that the analysis error in the DeepDA-produced three-dimensional temperature is systematically reduced compared to both the background and observed values. The DeepDA global temperature reanalysis for 1980-2020 successfully reconstructed the observed global climatological fields, seasonal cycle, and the dominant oceanic temperature variabilities. The DeepDA, which was formulated solely with a long-term control simulation, successfully lowers the technical barrier in obtaining global ocean reanalysis datasets using physical constraints in various numerical models, and thus, reduces the systematic uncertainties in estimating decades of global oceanic states using these models.
‘Harnessing the power of the law’: a qualitative analysis of the legal determinants of health in English urban planning and recommendations for fairer and healthier decision-making
Authors: Montel Lisa
Published: October 2022

Background: Urban environments impact negatively on the risks of non-communicable diseases and perpetuate health inequalities. Against this, law could play a critical role, notably through implementing and securing visions of health and well-being, and evidence-based interventions.
Methods: Seven teams conducted 123 interviews with 132 actors in urban planning in England. Teams had expertise in urban planning, transport, real estate, public health, public policy, administration, and management. An additional team with expertise in law analysed data from all interviews to explore how the law is perceived and used to promote health in urban planning.
Results: Six issues were identified as preventing actors from using the law to improve health in urban planning: i) density and complexity of the law; ii) weak and outdated regulatory standards; iii) absence of health from legal requirements in the decision-making process; iv) inconsistent interpretations by actors with competing interests; v) lack of strong health evidence-based local planning policies; and vi) inertia of the law.
Conclusions: The legal determinants of health listed in the Lancet-O’Neill Commission’s report need to be strengthened at the local level to effectively deploy law in English urban development. The findings call for strong, evidence-based local planning policies and decision-making frameworks, placing health as (one of the) core value(s) of urban planning and showing what types of development benefit health, i.e., prevent NCDs risks and reduce health inequalities on the long term. The legal capacity of local government should be strengthened to empower decision-makers in shaping urban development that promotes health for everyone.
Protein-Ligand Based Pharmacophore Approach against ERK5 Involved in Breast Cancer; In-Silico Study of Flavonoids from Blighia sapida
Authors: Bodun Damilola , Omoboyowa Damilola , Adedara Joshua F , Olugbogi Ezekiel , Atasie Nkechi , Oluwafemi Isaac
Published: October 2022

Conclusions: Flavonoids from B. sapida may serve as promising inhibitors of ERK5 for breast cancer management.
Background: Breast cancer is a global public health issue that can be caused by environmental or hereditary factors. There are still a shortage of effective treatments with enhanced efficacy and acceptability against the disease, as many breast cancer drugs have serious side effects. Hence, the inhibitory potential of flavonoids from Blighia sapida against breast cancer target (ERK5) was investigated.
The interactions of the target protein and its co-crystallized ligand were used to develop a protein-ligand based pharmacophore hypothesis. The idea was applied to the screening of phytochemicals obtained from an online database. Following that, we used structural bioinformatics and theoretical chemistry tools to find new ERK5 inhibitors using molecular docking, molecular mechanics generalized Born surface area (MM-GBSA) and pharmacokinetics model in Schrödinger suite, density functional theory analysis (DFT) was also performed using Spartan 10.
Results: The technique discovered new lead molecules as inhibitors of ERK5 as breast cancer therapy through molecular docking and MM/GBSA calculation with Quercetin, Kaempferol and (+)-Catechin showing higher docking score than the co-cystalized ligand and the standard drug. In the phase-generated E-pharmacophore theory, the postulated pharmacophore hypothesis has a hydrogen bond acceptor, hydrogen bond donor, and aromatic ring. Interestingly, all the hits obeyed Lipinski rule of five. The results of the frontier molecular orbitals revealed that the EHOMO values of the hit compounds range from -6.02 to -5.48 eV indicating that all the hit compounds will readily donate electron.
Conclusions: Flavonoids from B. sapida may serve as promising inhibitors of ERK5 for breast cancer management.
Revisiting Fertility Regulation in Tunisia
Authors: Frini Olfa , Muller Christophe
Published: October 2022

Background
In this paper we revisit fertility regulation in Tunisia. As marriage is the exclusive acknowledged childbearing context, we reconsider fertility analysis in Tunisia by examining family influence through the sequence: woman’s marriage age, post-marriage delay in the first use of contraception, and past and current contraceptive use.
Methods
Using data from the 2001 PAP-FAM Tunisian survey, we estimate duration and probability models of these birth control decisions.
Results
The significant effects of covariates are found to arise and vanish as women progress in their lifecycle and along changes in the family planning policies. Family links and socio-cultural environment appear to greatly shape fertility regulation.
Conclusion
This calls for family planning policies that address more the extended families.
Capsaicin ameliorates fatty accumulation both in mouse liver and in human hepatocytes
Authors: Gao Jing , Wang Shuqin , Li Xue , Xiao Leming , Jia Xiaoyuan , Ai Wen , Zhou Yanrong , Ye Ting , Chen Kan
Published: October 2022

Background:Nonalcoholic fatty liver disease (NAFLD) is a continuous spectrum of the disease recognized as excessive fatty accumulation in the liver, and no effective drugs are approved by FDA. Present study aimed to investigate whether capsaicin, the major ingredients of pepper, can ameliorate the progression of NAFLD. The underlying mechanism was also explored.
Methods:The function of capsaicin on lipid accumulation was assessed both in high-fat high-sugar diet (HFHSD) induced mice and in human hepatocytes. In animal experiments, mice were divided into three groups: normal diet (ND), HFHSD, and HFHSD subjected to capsaicin cream. The body weight, liver weight, lipid droplets, triglyceride (TG), and total cholesterol (TC) of each group were compared. In cell experiments, WRL68 cells were cultured with the palmitic and oleic acid (PAOA) mixture. The lipid accumulation was detected using fluorescence microscopy and flow cytometer. RT-qPCRwas performed to explore the potential mechanism of capsaicin.
Results: Topical application of capsaicin significantly decreased liver index (HFHSD vs HFHSD + Cap, 6.92 ± 1.47 vs 6.16 ± 1.13, mean ± SEM, n = 8) and ameliorated hepatic fatty accumulation (HFHSD vs HFHSD + Cap, 22.54 ± 4.53 vs 9.92 ± 4.42, mean ± SEM, n = 8) in HFHSD-fed mice. Capsaicin treatment decreased intracellular lipid accumulation in human hepatocytes. RT-qPCR showed that HFHSD feeding or PAOA exposure could significantly up-regulate the levels of SREBP-1c, ACC1, and CYP2E1, while capsaicin application reversed their expression.
Conclusion: Topical application of capsaicin ameliorates fatty accumulation both in mice and human hepatocytes, which may be related to de novo lipogenesis inhibition and ω-oxidation regulation.
Effect of probiotic supplementation on lipoprotein-associated phospholipase A2 in type 2 diabetic patients: a randomized double-blind clinical controlled trial
Authors: Jaff Salman , Gubari Mohammed , Shab-Bidar Sakineh , Djafarian Kurosh
Published: October 2022

Background: It has been recently reported that lipoprotein-associated phospholipase A2 (Lp-PLA2) may predict the risk of cardiovascular disease. The effect of multi-strain probiotics on Lp-PLA2 in patients with type 2 diabetes is still not clear. This study aimed to determine the effect of multi-strain probiotic supplementation on lipoprotein-associated phospholipase A2, and glycemic status, lipid profile, and body composition in patients with type 2 diabetes.
Methods: In this randomized double-blind placebo-controlled clinical trial, 68 participants with type 2 diabetes, in the age group of 50-65 years, were recruited and randomly allocated to take either probiotic (n= 34) or placebo (n= 34) for 12 weeks. The primary outcome was lipoprotein-associated phospholipase A2, and secondary outcomes were glycemic parameters, lipid profile, anthropometric characters, and body composition (fat mass and fat-free mass).
Results: There was a significant reduction in serum lipoprotein-associated phospholipase A2, in the probiotic group, it dropped by 6.4 units at the end of the study (p <0.001) compared to the placebo group. Probiotic supplementation also resulted in a significant improvements in the hemoglobin A1c and high-density lipoprotein cholesterol 1.5% (p <0.001) and 6 mg/dl (p 0.005). There were no significant changes in other outcomes.
Conclusion: We showed that probiotic supplementation was beneficial for reducing Lp-PLA2 and hemoglobin A1c and improving high-density lipoprotein cholesterol which may suggest an improvement in the prognosis in patients with type 2 diabetes.
Towards an Efficient, Privacy-aware Federated Learning Scheme
Authors: Alekszejenkó Levente , Dobrowiecki Tadeusz
Published: October 2022

With the rapid evolution of Internet-of-Things (IoT) devices and the emergence of Autonomous Vehicles (AVs), machine learning processes pose a growing privacy issue. Federated learning (FL) and current cryptography can mitigate this problem; however, these solutions might not be efficient enough during the decades-long lifespans of such gadgets.
In this paper, a generalization of FL schemes, incorporating sharing a part of raw data, is presented with a proof-of-concept experiment. Besides anonymization, the exchanged data portion can also directly support real-time decision-making. In contrast with cryptographical approaches, the proposed FL scheme can guarantee a certain level of privacy during the whole lifetime of IoT devices or AVs.
Monolithic Integration of Embedded III-V Lasers on SOI
Authors: Wang Ting , Wei Wen-Qi , He An , Yang Bo , Wang Zihao , Huang Jingzhi , Han Dong , Ming Ming , Guo Xuhan , Su Yikai , Zhang Jianjun
Published: October 2022

Silicon photonic integration has gained great success in many application fields owing to the excellent optical device properties and complementary metal-oxide semiconductor (CMOS) compatibility. Realizing monolithic integration of III-V lasers and silicon photonic components on single silicon wafer is recognized as a long-standing obstacle for ultra-dense photonic integration, which can provide considerable economical, energy efficient and foundry-scalable on-chip light sources, that has not been reported yet. Here, we demonstrate embedded InAs/GaAs quantum dot (QD) lasers directly grown on trenched silicon-on-insulator (SOI) substrate, enabling monolithic integration with butt-coupled silicon waveguides. By utilizing the patterned grating structures inside pre-defined SOI trenches and unique epitaxial method via hybrid molecular beam epitaxy (MBE), high-performance embedded InAs QD lasers with monolithically out-coupled silicon waveguide are achieved on such template. By resolving the epitaxy and fabrication challenges in such monolithic integrated architecture, embedded III-V lasers on SOI with continuous-wave lasing up to 85 oC are obtained. The maximum output power of 6.8 mW can be measured from the end tip of the butt-coupled silicon waveguides, with estimated coupling efficiency of approximately -7.35 dB. The results presented here provide a scalable and low-cost epitaxial method for realization of on-chip light sources directly coupling to the silicon photonic components for future high-density photonic integration.
Clinical predictors of surgical intervention for gastrointestinal magnetic foreign bodies in children
Authors: Zhang Ruiyun , Cai Peng , Zhang Tingting , Zhu Jie , Chen Jianlei , Zhao Haowei , Jiang Yuliang , Wang Qi , Zhu Menglei , Zhou Xiaogang , Xiang Xianlan , Hu Feilong , Gu Zhicheng , Zhu Zhenwei
Published: October 2022

Background/Aims: To investigate the clinical situation, treatment methods, and clinical predictors of surgical intervention in children with magnetic foreign bodies in the digestive tract.
Materials and Methods: From January 2019 to June 2022, we retrospectively analyzed the clinical data of 72 children who ingested magnetic foreign bodies inadvertently in our hospital, including their general information, admissions, clinical manifestations, and treatment methods, as well as pertinent literature and statistical data. Following software processing, univariate and multivariate logistic regression analyses were conducted to determine the independent risk factors of this study, and the receiver operating characteristic curve (ROC) was used to evaluate their predictive performance.
Results: Among the 72 children who accidentally ingested magnetic foreign bodies, 59 (86.8%) ingested foreign bodies, with an average of 3.42 days and 11.03 foreign bodies. The predominant symptoms were nausea and vomiting. 19 cases (31.2%), 33 cases (54.1%) with abdominal pain; 9 cases (14.8%) with peritoneal irritation; 13 cases (21.3%) within 24 hours with foreign body movement. Treatment: conservative in 16 cases (22.2%), gastroscope in 19 cases (26.4%), and surgery in 37 cases (51.4%), with gastrointestinal perforation occurring in 26 cases (70.3%). ROC (AUC = 0.808) for predicting surgical treatment plans for children with magnetic foreign body ingestion.
Conclusion: We found that nausea、vomiting and intermittent abdominal pain significantly increased the likelihood of surgical treatment in children undergoing surgery.
Transcriptome and metabolome reveal key genes in the phenylpropane pathway to regulate the floral fragrance of Rhododendron fortunei
Authors: Yang Guoxia , Yi Qin , Yonghong Jia , Xiaohong Xie , Dongbin Li , Baoxin Jiang , Qu Wang , Siyu Feng , Yueyan Wu
Published: October 2022

Background: Floral aroma is an important plant trait and it is one of the main traits of Rhododendron varieties which affect their ornamental value. The volatile compounds of floral aroma are secondary metabolites. In order to reveal the key genes of the phenylpropane pathway, which regulates the fragrance of Rhododendron fortunei, we performed a comprehensive transcriptome and metabolome analysis of the petals of the petals of two alpine rhododendrons from two different varieties: the scented Rhododendron fortunei and the non-scented Rhododendron ‘Nova Zembla’.
Results: Transcriptomic and qRT-PCR results showed that nine candidate genes were highly expressed in R. fortunei, but down-regulated in R. ‘Nova Zembla’. The correlation analysis of candidate genes and metabolites revealed nine key genes involved in the regulation of floral aroma in the phenylpropane pathway. Among them, EGS was significantly positively correlated with various volatile benzene/phenylpropane compounds, and significantly negatively correlated with various non-volatile compounds; CCoAOMT, PAL, C4H,and BALDH were significantly negatively correlated with various volatile benzene/phenylpropane compounds, and significantly positively correlated with various non-volatile compounds. CCR, CAD, 4CL, and EGSwere significantly negatively correlated with various benzene/phenylpropane compounds. The validation of RfSAMT proved that RfSAMT gene regulated the synthesis of aromatic substances in R. fortunei.
Conclusion: The findings of this study indicated that key candidate genes and metabolites involved in the biosynthetic pathway of phenylpropane may regulate the fragrance of R. fortunei. This lays a foundation for further research on the molecular mechanism of fragrance synthesis in the genus Rhododendron.
Impact of chronic kidney disease on the extent and severity of coronary plaque burden in general population: evaluation by Coronary CT angiography
Authors: Huang Shao-Sung , Hsu Pai-Feng , Lu Tse-Min , Chan Wan-Leong , Lin Shing-Jong , Chen Jaw-Wen , Leu Hsin-Bang
Published: October 2022

Background Previous studies have reported an association between chronic kidney disease (CKD) and coronary artery calcification. However, data on the quantitative assessment of coronary plaques in patients with CKD without overt coronary events are limited. The current study aimed to examine the association of CKD with the composition and burden of coronary atherosclerotic plaques in the general population.
Methods The authors studied 1747 subjects who underwent coronary computed tomographic angiography as part of health checkup. Atherosclerotic plaque burden was measured by atheroma burden obstructive score (ABOS), segment involvement score (SIS), and segment stenosis score (SSS). Based on the number of segments with plaques, the extent of coronary artery disease (CAD) was categorized as non-extensive (SIS ≤4 or SSS <7) or extensive (SIS >4 or SSS ≥7).
Results In all participants, calcified plaques were more frequently detected than mixed or non-calcified plaques. Regarding the grade of luminal stenosis, obstructive plaques (> 50% stenosis) were more frequently observed in the CKD group than in the non-CKD group. Individuals with CKD had significantly higher ABOS, SIS, and SSS than those without CKD. After adjusting for traditional risk factors, CKD was independently associated with obstructive mixed plaques (odds ratio [OR]: 1.937, P=0.012) and extensive CAD (SIS >4 [OR: 1.645; P=0.043]; SSS ≥7 [OR: 1.660; P=0.045]). Subgroup analyses revealed no significant heterogeneity between CKD and obstructive mixed plaques in each subgroup. However, a more prominent association between CKD and the risk of extensive CAD was observed in subjects aged <65 years.
Conclusions Renal dysfunction was independently associated with obstructive mixed plaque pattern and increased atherosclerotic plaque burden. Our findings support that CKD is a major risk factor for the development of obstructive and extensive CAD.
Mothers' Lived Experience of Caring for Children with Inborn Errors of Amino Acid Metabolism
Authors: Shirdelzade Sara , Heydari Abbas , Ramezani Monir , Eshraghi Peyman
Published: October 2022

Background
Inborn errors of amino acid metabolism are chronic conditions which have many sequels. Mothers of these children are facing different challenges which are underdetermined. This study was done to explore lived experience of mothers caring these children.
Methods
This is an interpretive phenomenology with Van Manen's approach which has 6 steps. Data were gathered by convenience and purposeful sampling. Nine mothers with different experiences were interviewed and audio taped.
Results
Six final themes were revealed from the exploring mothers' experiences including: future tied to past, psychosis in the shadow of lost ideal child, rebellion and blaming, the ways of escaping difficulties, self-forgetting in the shadow of full time care, passing difficulties in the duality of hope-hopelessness, caring in a continuum of isolation-socialization.
Conclusions
Mothers have multiple challenges in taking care of their children, especially psychologically and financially. So, nurses must plan programs for helping mothers of children with inborn errors of amino acid metabolism to reduce the effects of disease on mothers and consequently the children and whole family.
Investigation on the adsorption-desorption behavior of antibiotics by polybutylene succinate and polypropylene aged in different water conditions
Authors: Fan Xiulei , Li Weiyi , Alam Easar , Cao Binwen , Qian Shenwen , Shi Shang , Yang Yangyang
Published: October 2022

Microplastics (MPs) are widely present in the aqueous environment and aged by natural components, such as salinity (SI) and dissolved organic matter (DOM). The effects of multi-conditioned ageing on the physicochemical properties and environmental behavior of MPs are not completely investigated. In this study, the degradable MPs polybutylene succinate (PBS) was used to investigate the environmental behavior of sulfamethoxazole (SMZ), and compared it with polypropylene (PP). The results showed that the single conditions of DOM and SI, particularly DOM, promoted the ageing process of MPs more significantly, especially for PBS. The degree of MPs ageing under multiple conditions is lower than that of under single condition. Compared to PP, PBS has a greater specific surface area, crystallinity and hydrophilicity, so it has a stronger adsorption capacity for SMZ. The adsorption behavior of MPs fitted well with the pseudo-second-order kinetic and Freundlich isotherm models, indicating a multilayer adsorption. The desorption experiments showed that the desorption amount of SMZ on MPs in simulated intestinal fluid was greater than that in Milli-Q water. Both the original PBS and the aged PBS had a stronger desorption capacity than the PP. The desorption quantity of PBS was 1.23–1.84 times greater than PP, while the desorption rates were not significantly different. This experiment would provide a theoretical basis for assessing the ecological risks of degradable MPs in complex water conditions.
Reliability and Validity of PARENTS Tool for Assessment of Pediatric Residents’ Non- Technical Skills in a Tertiary Care Teaching Hospital of Pakistan
Authors: Talat Nabila , Khan Rehan Ahmed , Aziz Muhammad Usama , Tahir Warda , Mirza Muhammad Bilal
Published: October 2022

Background: Non-Technical Skills (NTS) of post graduate residents (PGR) are as important as their clinical skills. Other than direct observation of supervisors, the feedback of caregivers provides an objective assessment of medical residents’ ability to effectively deal with patients. Our research objective was to test the validity and reliability of an instrument named “PARENTS Tool” in a local environment and its use to evaluate NTS of residents at the hospital.
Methods: This multi-phase mixed-method study used an Instrument Design Model called PARENTS Tool to assess NTS of residents. The PARENTS tool was translated into Urdu for our local environment and administered in the emergency department of Children’s Hospital and The University of Child Health Sciences.
Results: The authors collected data from 471 parents and coded them for analysis in AMOS and SPSS. Both tests met acceptance criteria to establishes the validity and reliability of the Urdu version of PARENTS tool. Results showed that parents were satisfied with the knowledge and skill of residents but less satisfied with the patience or empathy that the residents showed towards the children under their care.
Conclusion:PARENTS has shown to be valid and reliable tool for measuring the NTS of residents from the patient’s perspective. Medical administrators can use PARENTS as a performance measurement tool for monitoring the soft side of patient care.