bluuebunny/crossref_metadata_2025 huggingface dataset:
Cholera Forecast for the Year 2019 Based on Assessment of Epidemiological Situation Around the World, Across CIS and Russia in 2009–2018
Authors: Moskvitina E. A. , Yanovich E. G. , Kruglikov V. D. , Titova S. V. , Kurilenko M. L. , Pichurina N. L. , Vodop’yanov A. S. , Levchenko D. A. , Ivanova S. M. , Vodop’yanov S. O. , Oleynikov I. P.
Published: April 2019

Analysis of cholera incidence for the period of 2009–2018 was performed. The upward tendency in the morbidity rate dynamics around the world (compared to 2009) with an average annual growth rate of 5,352 % was revealed. For the first time during the 7th pandemic caused by V. cholerae O1 El Tor, WHO reported 1227391 cases of cholera world-wide in 2017, out of which 1032481 (84.1%) were registered in Yemen, where the war continues and one of the largest epidemics in the world. There have been cross-border epidemiological complications in several African countries. Endemic foci continue to exist and spread in Asia, Africa and the Caribbean. Under the epidemiological surveillance in Russia, 744 strains of V. cholerae El Tor – ctxA– tcpA–, ctxA– tcpA+ and V. cholerae О139 ctxA– and tcpA– were isolated from the surface water bodies, as well as single strains of El Tor ctxA+ tcpA+. As a result of INDEL- and  PCR-genotyping, the isolation of strains with identical genotypes and new ones was established. To make the prognosis for 2019, the risk of activation (continuation) of the cholera epidemic process in the world was assessed, taking into account emergencies of different origin and risk factors. The cholera forecast at the global level and in  Russia for 2019 is unfavorable.
Tick-Borne Viral Encephalitis Morbidity Rates in the Constituent Entities of the Russian Federation. Communication 1: Epidemiological Situation on Tick-Borne Viral Encephalitis in 2018 and Forecast for 2019
Authors: Noskov A. K. , Andaev E. I. , Nikitin A. Ya. , Pakskina N. D. , Yatsmenko E. V. , Verigina E. V. , Tolmacheva M. I. , Balakhonov S. V.
Published: April 2019

Epidemiological situation on tick-borne viral encephalitis in the Russian Federation in 2018 was analyzed. Dynamics of the incidence, medical aid appealability among persons who suffered from tick suction, virus carriage of the vector; vaccination volumes, seroprophylaxis; acaricide treatment are reported in the paper. Utilized were the data on operative monitoring performed by the Rospotrebnadzor Institutions in the constituent entities of the Russian Federation and form data from the Federal statistical survey «Data on Infectious and Parasitic Diseases» over the period of 2009–2017, and also information from the operative monitoring, 2018. The increase in medical aid appealability among the population due to tick suctions was observed in all endemic Federal Districts (FD) of the European part of the Russian Federation during the epidemic season, 2018. The total of 1508 cases in 46 constituent entities of the country was registered: Siberian FD – 44.3 % of the cases, Privolzhsky FD – 22 %, Ural FD – 14.7 %, Northwest FD – 12.6 %,Central FD – 3.7 % , and Far Eastern FD – 1.7 %. Twenty two cases had lethal outcomes. Nation average infection rate of ticks taken off from humans was 1.38 %, from environment objects – 0.61 %. General level of tick infectivity was 1.5 times lower in 2018 as compared to 2017. The forecast of the incidence for 2019, taking into account the presence or absence of the trend fluctuations in the constituent entities in 2009–2018 and the values of the 95 % confidential interval of the possible parameter variations, is presented. The further gradual improvement of the epidemiological conditions for tick-borne viral encephalitis is expected. According to estimates, in 2019, morbidity rates will be 0.19 0/0000 in CentralFD, with value fluctuations ranging between 0.128 to 0.247 cases, in Northwest FD – 1.12 0/0000 (0.112 to 2.122 0/0000), Privolzhsky FD – 0.67 0/0000 (0↔1.649), Ural FD – 1.2 0/0000 (0↔4.590), Siberian FD – 3.4 0/0000 (1.319↔5.471), and Far Eastern – 0.65 0/0000 (0.522↔0.770).
Potent Anticoagulation Does Not Reduce Venous Thromboembolism in High-Risk Patients
Authors: Tan Timothy L. , Foltz Carol , Huang Ronald , Chen Antonia F. , Higuera Carlos , Siqueira Marcelo , Hansen Erik N. , Sing David C. , Parvizi Javad
Published: April 2019

Background:

Based on current guidelines from the American Academy of Orthopaedic Surgeons (AAOS), a number of prophylactic modalities for the prevention of venous thromboembolism in total joint arthroplasty may be used. It is common practice that more potent prophylactic agents are used for patients at higher risk of venous thromboembolism. However, we are aware of no studies that have investigated the efficacy of potent anticoagulation in higher-risk individuals. Therefore, the purpose of our study was to test the hypothesis that low-molecular-weight heparin and warfarin result in a reduction in venous thromboembolism events in high-risk patients.

Methods:

A retrospective, multi-institutional study of 60,467 primary and revision total joint arthroplasties from 2000 to 2015 was performed. Identified medications were classified as aspirin, low-molecular-weight heparin, or warfarin. Patients with unavailable venous thromboembolism prophylaxis information or those not receiving the aforementioned prophylaxis were excluded. Information pertinent to the objective of this study was collected and a venous thromboembolism risk score was calculated based on 26 variables. Treatment outcomes assessed included 90-day rate of symptomatic venous thromboembolism and periprosthetic joint infection. Propensity score matching was performed (1:1), as well as logistic regression analysis on the total sample.

Results:

Aspirin prophylaxis demonstrated a lower rate of deep vein thrombosis, pulmonary embolism, and venous thromboembolism than warfarin and low-molecular-weight heparin alone throughout all risk scores. In the matched propensity score analysis, low-molecular-weight heparin and warfarin demonstrated increased odds of venous thromboembolism for both standard-risk and high-risk patients undergoing total knee arthroplasties compared with aspirin. For primary total hip arthroplasty, warfarin demonstrated an increased risk for high-risk patients and low-molecular-weight heparin demonstrated an increased risk for standard-risk patients. The prevalence of periprosthetic joint infection was higher in patients receiving warfarin (p < 0.001 for both comparisons of warfarin with aspirin and low-molecular-weight heparin).

Conclusions:

The results of this multi-institutional study demonstrate that the use of warfarin and low-molecular-weight heparin in higher-risk patients does not necessarily result in a reduction in symptomatic venous thromboembolism. Aspirin administered to higher-risk patients seems to be as effective as potent anticoagulation and more effective than warfarin.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Generalized Joint Laxity in Orthopaedic Patients
Authors: Sacks Hayley A. , Prabhakar Pooja , Wessel Lauren E. , Hettler Jessica , Strickland Sabrina M. , Potter Hollis G. , Fufa Duretti T.
Published: April 2019

➤ Careful history and examination may reveal a constellation of musculoskeletal conditions associated with generalized joint laxity, including shoulder instability, posterolateral rotatory instability of the elbow, wrist ganglia, thumb base pathology, hip labral pathology, and patellar and ankle instability.

➤ Subtle but highly suggestive findings associated with generalized joint laxity may be recognized on radiographs or magnetic resonance imaging that can impact the clinician’s decision-making.

➤ Increasing evidence has suggested that clinical outcomes of various surgical procedures around the shoulder, hip, knee, and ankle may be impacted in patients with generalized joint laxity. Surgeons should counsel these patients accordingly to manage expectations.

➤ Patients presenting to orthopaedic specialists should be queried about symptoms and injuries in other joints to identify patients with generalized joint laxity in order to initiate early management and injury prevention protocols.
Long-Term Outcomes of Constrained Liners Cemented into Retained, Well-Fixed Acetabular Components
Authors: Brown Timothy S. , Tibbo Meagan E. , Arsoy Diren , Lewallen David G. , Hanssen Arlen D. , Trousdale Robert T. , Abdel Matthew P.
Published: April 2019

Background:

Cementation of a constrained liner is a viable option for treating instability after total hip arthroplasty (THA) when the acetabular component is well fixed and well aligned. However, concerns regarding long-term mechanical failure and recurrent instability remain. The aim of this study was to evaluate the long-term survivorship, complications, and clinical and radiographic outcomes of constrained polyethylene liners cemented into well-fixed acetabular components at the time of revision THA.

Methods:

We identified 125 cases in which a constrained liner of 1 design was cemented into a retained, osseointegrated acetabular component during revision THA between 1998 and 2006. The mean patient age at revision was 70 years. Mean follow-up was 7 years. Survivorship data, risk of instability, and clinical and radiographic outcomes were analyzed.

Results:

Survivorship free from revision for instability was 86% at 5 years and 81% at 10 years. Survivorship free from aseptic acetabular component revision was 78% at 5 years and 65% at 10 years, with the most common failure mechanism being dissociation of the constrained liner from the acetabular component. Survivorship free from revision for any reason was 76% at 5 years and 60% at 10 years. The most common complications were instability and periprosthetic joint infection, with cumulative incidences at 7 years of 18% and 11%, respectively. Harris hip scores did not significantly improve. Cup position did not affect implant survivorship or risk of dislocation.

Conclusions:

Cementing a constrained liner into a retained acetabular shell at the time of revision THA has durable long-term results, with 8 in 10 patients free from instability at 10 years. Aseptic acetabular survivorship was worse (65%) at 10 years, primarily due to dissociation of the constrained liner from the acetabular component.

Level of Evidence:

TherapeuticLevel IV. See Instructions for Authors for a complete description of levels of evidence.
PELAKSANAAN LELANG TERHADAP OBYEK YANG DIBEBANI HAK TANGGUNGAN DALAM RANGKA MEWUJUDKAN KEADILAN PARA PIHAK
Authors: Nugroho Pandu Dwi
Published: April 2019

Penelitian ini membahas tentang pelaksanaan lelang terhadap obyek lelang yang dibebani hak tanggungan dalam rangka mewujudkan keadilan para pihak. Pengaturan mengenai Hak Tanggungan diatur dalam Undang – Undang No.4 Tahun 1996 Tentang Undang – Undang Hak Tanggungan (UUHT). Permasalahan penelitian ini mengenai apakah obyek lelang dengan agunan yang telah dipasang Akta Pembebanan Hak Tanggungan dapat langsung dilelang melalui Kantor Pelayanan Kekayaan Negara dan Lelang serta bagaimana pelaksanaan lelang terhadap obyek hak tanggungan yang dapat mewujudkan keadilan para pihak. Untuk menjawab permasalahan tersebut diperlukan kegiatan penelitian hukum, menggunakan pendekatan yuridis normatif.  Sumber data diperoleh melalui sumber kepustakaan yaitu peraturan perundang-undangan, teori hukum, dan pendapat para sarjana terkemuka sebagai sumber data utama, kemudian menganalisisnya agar mendapat jawaban secara ilmiah. Hasil Pembahasan dari penelitian ini : Pelaksanaan lelang dilakukan oleh Kantor Pelayanan Kekayaan Negara dan Lelang yang selanjutnya disebut dengan KPKNL diatur dalam Peraturan Menteri Keuangan No. 102 /PMK.01/2008 tentang Organisasi Dan Tata Kerja Instansi Vertikal Direktorat Jendral Kekayaan Negara Pasal 29 ayat (1), bahwa Kantor Pelayanan Kekayaan Negara dan Lelang (KPKNL) merupakan instansi vertikal Direktorat Jenderal Kekayaan Negara (DJKN) yang berada dibawah dan bertanggung jawab langsung kepada Kepala Kantor Wilayah yang dipimpin oleh seorang Kepala. Dalam Undang – Undang No.4 Tahun 1996 Pasal 10 ayat (1) menyatakan bahwa Pemberian hak tanggungan didahului dengan janji untuk memberikan hak tanggungan sebagai jaminan pelunasan hutang tertentu, yang merupakan bagian tak terpisahkan dari perjanjian utang piutang yang bersangkutan. Objek yang dibebankan atas hak tanggungan berada di bawah kekuasaan penerima hak tanggungan.Hal ini bertujuan untuk memberikan perlindungan dan kepastian hukum kepada kreditur apabila debitur cidera janji. Jika terjadi cidera janji, benda yang dijaminkan dengan hak tanggungan akan dijual untuk melunasi utang debitur yang dijamin tersebut.
Salud mental infantil: una prioridad a considerar
Authors: Caraveo-Anduaga Jorge Javier , Martínez-Vélez Nora Angélica
Published: April 2019

Objetivo. Identificar posibles cambios en la frecuencia de manifestaciones sindromáticas sugerentes de problemas de salud mental en población infantil mexicana empleando el Cuestionario Breve de Tamizaje y Diagnóstico (CBTD), a lo largo de 15 años. Material y métodos. Se analiza información de diferentes estudios en población general, escuelas y práctica médica. La estimación obtenida en la Ciudad de México fue utilizada como población de referencia para comparación. Resultados. Se apreciaron incrementos notables respecto a la prevalencia de síndromes como el déficit de atención e hiperactividad, y conducta oposicionista y explosiva, así como manifestaciones de ansiedad y depre­sivas. Estas últimas resultaron más frecuentes en la edad escolar tardía. Las alteraciones en el lenguaje y la epilepsia también mostraron incremento en diferentes grupos de edad. Conclusiones. Se discuten los hallazgos a la luz de estudios longitudinales en la literatura, así como de reportes de población adolescente en nuestro país.
Factores asociados con la exposición al humo de tabaco de segunda mano en lugares públicos y privados en México. Encodat 2016
Authors: Zavala-Arciniega Luis , Gutiérrez-Torres Daniela Sarahí , Paz-Ballesteros Wayra Citlali , Reynales-Shigematsu Luz Myriam , Fleischer Nancy L
Published: April 2019

Objetivo. Determinar los factores asociados con la ex­posición al humo de tabaco de segunda mano (HTSM) en lugares públicos y privados. Material y métodos. Se analizó la Encuesta Nacional de Consumo de Drogas, Alcohol y Tabaco 2016. La exposición al HTSM se evaluó mediante modelos Poisson multinivel. La muestra del estudio incluye únicamente no fumadores. Resultados. La exposición al HTSM fue similar en los estados que tienen prohibición total para fumar en espacios cerrados en comparación con estados con prohibición parcial. Adultos jóvenes, hombres y personas con nivel educativo alto tienen mayor exposición al HTSM en bares y restaurantes. Los hombres tienen mayor exposición al HTSM en el trabajo, los adultos de mayor edad en el transporte público, mientras las mujeres y adolescentes en el hogar. Conclusiones. La exposición al HTSM continúa elevada y afecta diferencialmente a la población mexicana. Para reducirla, se requiere aplicar totalmente el artículo octavo del Convenio Marco para el Control del Tabaco.
Strategic Evaluation of Managed Pressure Drilling: An Application on Brazilian Dynamic-Positioning Rigs
Authors: Aranha Pedro Esteves , Colombo Danilo , Fernandes André Alonso , Vanni Guilherme Siqueira , Tomita Reinaldo Akio , Benevenuto de Campos Lima Cláudio , Lima Gilson Brito , César de Faria Alvim Wasserman Júlio
Published: April 2019

The demand for ultradeepwater scenarios invoked the frequent application of managed pressure drilling (MPD) in the last few years. In an ultradeepwater scenario, oil companies face issues such as narrow pressure windows and severe loss zones. Many wells are considered undrillable without the aid of MPD technology. MPD operations need to be correctly evaluated with consideration given to increased time and cost/benefit analysis. In this paper, we propose a probabilistic model to evaluate MPD demand by estimating the optimal number of rigs equipped with MPD and a rotating control device (RCD), and we analyze which intervention strategy is the most cost– and time–effective. Reducing uncertainty is an important factor when making decisions about drilling. We adopted a Monte Carlo simulation using loss–zone estimation, probability of prediction error, the number of rigs equipped with MPD, and several strategies. Better MPD strategies were determined on the basis of available data and the optimal number of rigs equipped with an MPD system and RCD equipment, reducing subjectivity in the decision–making process. The originality of our paper lies in the new quantitative approach to dealing with uncertainty in the prediction of fluid losses and the cost and duration of different MPD strategies, numerically simulating the possible scenarios.
Monolayer Microproppant-Placement Quality Using Split-Core-Plug Permeability Measurements Under Stress
Authors: Kim Brice Y. , Akkutlu I. Yucel , Martysevich Vladimir , Dusterhoft Ronald G.
Published: April 2019

The stress-dependent permeabilities of split shale core plugs from Eagle Ford, Bakken, and Barnett Formation samples are investigated in the presence of microproppants. An analytical permeability model is developed for the investigation, including the interactions between the fracture walls and monolayer microproppants under stress. The model is then used to analyze a series of pressure-pulse-decay measurements of the propped shale samples in the laboratory. The analysis provides the propped-fracture permeability of the samples and predicts a parameter related to the quality of the proppant areal distribution in the fracture. The proppant-placement quality can be used as a measure of success of the delivery of proppants into microfractures and to design stimulation experiments in the laboratory.
CO2 Stripping of Kerogen Condensates in Source Rocks
Authors: Baek Seunghwan , Yucel Akkutlu I..
Published: April 2019

Significant research has been conducted on hydrocarbon fluids in the organic materials of source rocks, such as kerogen and bitumen. However, these studies were limited in scope to simple fluids confined in nanopores, while ignoring the multicomponent effects. Recent studies using hydrocarbon mixtures revealed that compositional variation caused by selective adsorption and nanoconfinement significantly alters the phase equilibrium properties of fluids. One important consequence of this behavior is capillary condensation and the trapping of hydrocarbons in organic nanopores. Pressure depletion produces lighter components, which make up a small fraction of the in-situ fluid. Equilibrium molecular simulation of hydrocarbon mixtures was carried out to show the impact of CO2 injection on the hydrocarbon recovery from organic nanopores. CO2 molecules introduced into the nanopore led to an exchange of molecules and a shift in the phase equilibrium properties of the confined fluid. This exchange had a stripping effect and, in turn, enhanced the hydrocarbon recovery. The CO2 injection, however, was not as effective for heavy hydrocarbons as it was for light components in the mixture. The large molecules left behind after the CO2 injection made up the majority of the residual (trapped) hydrocarbon amount. High injection pressure led to a significant increase in recovery from the organic nanopores, but was not critical for the recovery of the bulk fluid in large pores. Diffusing CO2 into the nanopores and the consequential exchange of molecules were the primary drivers that promoted the recovery, whereas pressure depletion was not effective on the recovery. The results for N2 injection were also recorded for comparison.
Dynamics of Drilling Systems With an Antistall Tool: Effect on Rate of Penetration and Mechanical Specific Energy
Authors: Vromen Thijs , Detournay Emmanuel , Nijmeijer Henk , van de Wouw Nathan
Published: April 2019

This paper considers the effect of an antistall tool on the dynamics of deep drilling systems. Field results show that the antistall tool increased the rate of penetration (ROP) of drilling systems when compared with ROP in offset wells drilled without this tool. We developed a model–based approach to investigate the effect of this downhole tool on the ROP and on the mechanical specific energy. Toward this, a drillstring model including the antistall tool was constructed; it describes the coupled axial/torsional dynamics in the form of delay differential equations. Simulation results and a dynamic analysis based on averaging the obtained steady–state response show that an increased drilling efficiency was obtained using the antistall tool, resulting in a higher ROP.
Erratum to: Heme Oxygenase-2 Is Neuroprotective in Cerebral Ischemia
Authors: Doré Sylvain , Sampei Kenji , Goto Shozo , Alkayed Nabil J. , Guastella Daniel , Blackshaw Seth , Gallagher Michela , Traystman Richard J. , Hurn Patricia D. , Koehler Raymond C. , Snyder Solomon H.
Published: April 2019

Sylvain Doré, Kenji Sampei, Shozo Goto, Nabil J Alkayed, Daniel Guastella, Seth Blackshaw, Michela Gallagher, Richard J Traystman, Patricia D Hurn, Raymond C Koehler, and Solomon H Snyder. (1999) Heme Oxygenase-2 Is Neuroprotective in Cerebral Ischemia. Mol. Med. 1999 Oct;5(10):656–663.
Demographic profile, clinical features, and outcome of peripapillary subretinal hemorrhage: an observational study
Authors: Zou Ming , Zhang Yi , Huang Xi , Gao Sheng , Zhang Junjun
Published: April 2019

Background

To evaluate the etiology, demographic profile, clinical features, and outcomes in patients with peripapillary subretinal hemorrhage (PSH).

Methods

Thirty-eight eyes of 37 consecutive patients with PSH were enrolled in this prospective observational study over 4 years; all were followed for 2 years. The main outcome measures were demographic profile, possible etiology, clinical features, outcome, and prognosis.

Results

Sixty-eight percent (26/38) of eyes were in female patients; the mean patient age was 20 years. Only 1 patient (1/37) showed bilateral involvement. All patients experienced acute onset of PSH. All eyes were myopic and their best-corrected visual acuities ranged from 20/1000 to 20/12.5. The fundus features of affected eyes were classified into 3 groups: (1) PSH alone (4/38 eyes, 10.5%); (2) PSH with intrapapillary hemorrhage (17/38 eyes, 44.7%); (3) PSH with intrapapillary and vitreous hemorrhage (17/38 eyes, 44.7%). PSH occurred in nasal edges of optic discs with a crescent shape and dull-red color. All affected optic discs were small and crowded, exhibiting variable degrees of tilting. The cup of affected optic discs was narrower and deeper than that of normal control discs. Other ancillary tests provided no additional value. After a mean follow-up of 2.85 months, the hemorrhages resolved spontaneously without sequelae. Recurrence of disease was not observed in any patients.

Conclusions

PSH is common in myopic eyes with tilted optic discs. We suspect that these hemorrhages occurred as a result of abrupt movement acting on a morphologically vulnerable optic disc.
Neurosyphilis presenting with myelitis-Case series and literature review
Authors: Wu Yali , Wu Wenqing
Published: April 2019

Background
Neurosyphilis is a great imitator because of its various clinical symptoms. Syphilitic myelitis is extremely rare manifestation of neurosyphilis and often misdiagnosed. However, a small amount of literature in the past described its clinical manifestations and imaging features, and there was no relevant data on the prognosis, especially the long-term prognosis. In this paper, 4 syphilis myelitis patients admitted to our hospital between July 2012 and July 2017 were retrospectively reviewed. In the 4 patients, 2 were females, and 2 were males. We present our experiences with syphilitic myelitis, discuss the characteristics, treatment and prognosis.
Case presentation
The diagnosis criteria were applied: (1) diagnosis of myelitis established by two experienced neurologist based on symptoms and longitudinally extensive transverse myelitis (LETM) at the cervical and thoracic levels mimicked neuromyelitis optic (NMO) on magnetic resonance imaging (MRI) ; (2) Neurosyphilis (NS) was diagnosed by positive treponema pallidum particle assay (TPPA) and toluidine red untreated serum test (TRUST) in the serum and CSF; (3) negative human immunodeficiency virus (HIV). Likewise, all patients were negative for serum anti-aquaporin 4 (AQP-4), as well as negative bacterial, fungal, virus, or mycobacterium tuberculosis in the CSF. Treatment included intravenous penicillin G, with 24 million units of penicillin G per day administered intravenously for 14 days, and three patients were also treated with systemic corticosteroids. Neurological examination, serologic syphilis diagnostic tests (TPPA, TRUST) and cerebrospinal fluid tests (TPPA, TRUST) were examined approximately every 12~24 weeks after treatment. The follow-up time ranged from 12 to 70 months, with an average of 36.6 months. The prognosis was well in 3 cases who received early anti-syphilis treatment, but 1 case who received delayed treatment due to misdiagnose had no improvement.
Conclusions
Neurosyphilis should be considered when there are long hyperintensity lesions in the MRI spinal cord. Prompt diagnosis and combined antibiotics-corticosteroid therapy may improve neurological prognosis.
PREREQUISITES FOR THE FORMATION OF D - ENANTIOMERS OF AMINO ACIDS OF ANIMAL PROTEINS IN THE MANUFACTURING PROCESS OF MEAT PRODUCTS
Authors: Vostrikova Natal’ya L. , Kuznetsova Oksana A. , Krylova Valentina B. , Kulikovskii Andrey V.
Published: April 2019

The paper presents studies on the presence or formation of d - enantiomers of amino acids in animal tissues or organs, in meat products during its production processes. It is shown that the process of epimerization of L - amino acid residues with the formation of D-enantiomers affect the reduction of the properties of food products, including the formation of oncoassociated subsequent effects on the human body.

Modern control of the quantitative and qualitative composition of d-enantiomers of amino acids in food products, monitoring for stratification of the increased risk of toxic compounds in food are becoming an urgent medical and social problem. The studies planned in this paper are aimed at developing approaches to the creation of food products that reduce the oncogenic alimentary load on human health by solving the problem of technological modification of production, eliminating or minimizing post - translational modifications in proteins that contribute to the formation of d-enantiomers of amino acids. These studies will create a scientific and technological database associated with the risk assessment of carcinogenesis in protein matrices of animal origin. Based on the presented analysis, the task of developing and testing a method to control the accumulation of D-isomers in the course of various technological processes of meat production is extremely popular.
THE INFLUENCE OF IONIZING RADIATION ON THE THERMOPHYSICAL PROPERTIES OF MEAT FROM THE BROILER CHICKENS WITH DIFFERENT STRESS RESISTANCE
Authors: Timakova Roza T. , Tikhonov Sergey L. , Tikhonova Natal’ya V. , Shikhalev Sergey V. , Kudryashov Leonid S.
Published: April 2019

The studies on the influence of radiation treatment of carcasses from the stress-resistant and stress-sensitive broiler chickens on the thermophysical properties of raw meat are presented. An increase in thermal diffusivity of meat from the stress-resistant poultry by 24.7 % and 54.7 % after radiation treatment of carcasses with ionizing radiation doses of 9 kGy and 12 kGy, respectively, was established. In meat from the stress-sensitive poultry, this figure increased by 33.3 % and 35.8 % compared to the untreated carcasses.

It is shown that radiation treatment of carcasses by applied doses increased the thermal conductivity coefficient of meat from the stressresistant poultry by 5.3% and 7.0 %; in meat from the stress-sensitive poultry, this figure increased by 2.0 and 6.2 times compared to meat from the carcasses not exposed to radiation. At the same time, the value of the heat capacity coefficient was reduced. The irradiated poultry meat samples accumulate energy of ionizing radiation more intensively, which allows the intensification of the thermal processes occurring at various stages of meat product production. Treatment of meat from the stress-resistant poultry with ionizing radiation can reduce the amount of meat with non-traditional autolysis due to changes in its functionaltechnological properties. The results of the research should be taken into account in technological processes in the production of meat products with non-traditional autolysis.
CLIMATE CHANGE: IMPACT ON MYCOTOXINS INCIDENCE AND FOOD SAFETY
Authors: Milicevic Dragan , Lakicevic Brankica , Petronijevic Radivoj , Petrovic Zoran , Jovanovic Jelena , Stefanovic Srdjan , Jankovic Sasa
Published: April 2019

Climate change may have an impact on the occurrence of food safety hazards along the entire agri-food chain, from farm to fork. The interactions between environmental factors and food contamination, food safety and foodborne diseases are very complex, dynamic and difficult to predict. Extreme weather conditions such as floods and droughts which have not occurred previously in Serbia, may be supporting factors to contamination of crops by various species of toxigenic fungi and related mycotoxins. Mycotoxins are a group of naturally occurring toxic chemical substances, produced mainly by microscopic filamentous fungal species that commonly grow on a number of crops and that cause adverse health effects when consumed by humans and animals. Recent drought and then flooding confirmed that Serbia is one of the few European countries with very high risk exposure to natural hazards, as well as that mycotoxins are one of the foodborne hazards most susceptible to climate change.
Comments on black hole interiors and modular inclusions
Authors: Jefferson Ro
Published: April 2019

We show how the traversable wormhole induced by a double-trace
deformation of the thermofield double state can be understood as a
modular inclusion of the algebras of exterior operators. The effect of
this deformation is the creation of a new region of spacetime deep in
the bulk, corresponding to a non-trivial center between the left and
right algebras. This set-up provides a precise framework for
investigating how black hole interiors are encoded in the CFT. In
particular, we use modular theory to demonstrate that state dependence
is an inevitable feature of any attempt to represent operators behind
the horizon. Building on this geometrical structure, we propose that
modular inclusions may provide a more precise means of investigating the
nascent relationship between entanglement and geometry in the context of
the emergent spacetime paradigm.
Sistema web para la gestión y monitoreo del plan de vacunación del municipio de Medellín - SISMOVAC
Authors: Muñoz Mazo David , Gómez Echeverry Lesly Lisbeth , Álvarez Tobón Margarita María , Giraldo Vásquez Mario Alejandro
Published: April 2019

Las infraestructuras tecnológicas dinámicas, como la computación en la nube, representan una nueva alternativa de información disponible para administrar las actividades de las organizaciones que hacen uso intensivo de la información, como lo es la gestión de la información del plan de vacunación del municipio de Medellín. Estas herramientas deben estar basadas en arquitecturas confiables, de fácil implementación y manipulación. Para este proyecto se desarrolló un sistema web denominado SISMOVAC, cuyo objetivo es gestionar la información de los niños que participan en el programa de vacunación del municipio de Medellín. El sistema genera una encuesta donde se registra la información tanto de los niños que han sido vacunados, como los que aún no, cuáles vacunas les han sido aplicadas y cuáles les faltan. También se registra la EPS a la que pertenece el niño, la vigencia del carnet de vacunación, la comuna, el barrio y los datos básicos de la residencia como la dirección y teléfono. El sistema fue implementado y es usado en el área de vacunación del municipio de Medellín. Con este sistema web se garantiza que la información almacenada y la que aparece en los reportes sea segura y confiable para una asertiva toma de
decisiones.

Para el análisis, el diseño y el desarrollo de la aplicación se empleó la metodología orientada a objetos, utilizando lenguajes de programación Java Web, Html5, Dreamweaver CS3 y la base de datos en MySQL. Para el diseño del sistema se utilizó el Framework Bootstrap al igual que el plugin Jquery para su adaptación en la web y para usarlo en cualquier dispositivo móvil o tableta, ya que estos dispositivos son los que van a ser utilizados por los usuarios del sistema.
Computación en la Nube: Estudio de herramientas orientadas a la Industria 4.0
Authors: Ortiz Clavijo Luis Felipe , Fernández Ledesma Javier Darío , Cadavid Nieto Santiago , Gallego Duque Carlos Julián
Published: April 2019

La computación en la nube ha transformado la forma en que muchas organizaciones gestionan sus actividades, lo que representa beneficios donde se incluyen: ahorro de costos, agilidad, eficiencia, consolidación de recursos y nuevas oportunidades de negocio; este artículo de revisión tiene como propósito identificar las herramientas en la nube existentes con potencial de uso para la digitalización industrial, como marco de referencia para un programa de investigación enfocado a la consecución de estrategias para el desarrollo de la industria 4.0 en las pequeñas y medianas empresas de Colombia; para cumplir este objetivo se efectúa un estudio del estado del arte de las herramientas y su campo de acción desde el año 2011 (año de aparición del concepto industria 4.0) hasta la fecha.
Creatividad e innovación: Motores de desarrollo empresarial
Authors: Córdoba Zuñiga Eulices , Castillo Quesada Noé , Castillo Toro Jency Lorena
Published: April 2019

Este artículo analiza la creatividad e innovación como elementos claves del desarrollo empresarial. En este sentido, se ofrecen nuevas interpretaciones desde una extensa revisión bibliográfica que identifica, analiza y discute las razones por las cuales, la creatividad e innovación permiten mayores posibilidades de alcanzar en éxito en las empresas. Para recolección de la información, se empleó una metodología documental de corte analítico-descriptivo, que recuperó, examinó y discutió los aportes teóricos de cincuenta autores nacionales e internacionales. Los resultados sugieren que, la creatividad e innovación facilita la generación de nuevas ideas y propuestas de mercadeo que lleva a las empresas a ser más productivas y competitivas en mercados mediados por las crisis económicas, la exacerbada competencia comercial y los constantes cambios financieros del presente. Finalmente, se observa que la inclusión dichos elementos favorece el crecimiento comercial, económico y social de las empresas.
El amor desde la perspectiva de Friedrich Nietzsche: el amor nos hace humanos, demasiado humanos
Authors: Súarez Gómez William Camilo
Published: April 2019

El presente artículo se deriva del semillero de investigación Insan adscrito a la Facultad de Educación y Humanidades, programa de Filosofía. Este ejercicio académico pretende abordar el concepto de amor y su desarrollo, tratando en principio las nociones de Eros y Agápē para posteriormente analizar el concepto en la obra del filósofo alemán Friedrich Nietzsche, dando a conocer su postura vitalista sobre algo tan humano que está más allá del bien y del mal.
La experiencia del dolor como generador de conocimiento y construcción del pensamiento
Authors: Mesa Monroy Eddie Santiago
Published: April 2019

El presente artículo es derivado del semillero Insan adscrito a la Facultad de Educación y Humanidades. En este se propone la experiencia del dolor como un estado que permite la construcción del conocimiento, vínculo epistemológico entre el mundo y el pensamiento. Allí se inicia la experiencia del dolor, no solo en la vivencia del sentir, sino también como una interpretación que logra esclarecer un conocimiento ligado a la razón, desde la perspectiva formada de Schopenhauer, obteniendo una distinción y un camino de cómo funciona el dolor y cómo de este se forma el conocimiento después de sentirlo, dando la combinación de la vivencia del sentir y la edificación del conocimiento
Clopidogrel as a part of double disaggregant therapy in ACS: a reasonable choice in complex clinical situations
Authors: Kashtalap V. V. , Barbarash O. L.
Published: April 2019

Based on the recommendations of the European Heart Society and the results of clinical and register studies, the article highlights the complex issues that arise when prescribing antiplatelet therapy in patients with acute coronary syndrome, including with concomitant atrial fibrillation (AF); the promising strategies for managing the risk of ischemic and hemorrhagic events are described. Also a clinical case of a patient with acute coronary syndrome and AF is presented, illustrating the objective complexity of correct selection of antiplatelet therapy in such patients.
New targets and old therapies for arterial hypertension
Authors: Gilyarevsky S. R. , Bendeliani N. G. , Golshmid M. V. , Zakharova G. Yu. , Kuzmina I. M. , Sinitsina I. I.
Published: April 2019

The article discusses approaches to the choice of antihypertensive drugs, which may be based on the adoption and implementation of new clinical guidelines for the management of patients with arterial hypertension. This paper provides data on the efficacy and safety of candesartan, an antihypertensive drug, which advantages were identified during a large number of randomized clinical trials. It discusses the recently published data on the effectiveness of more intensive regimens of antihypertensive therapy to reduce the risk of moderate cognitive impairment in patients with arterial hypertension. In this regard, the authors provide data of the previously completed studies, which showed the effect of candesartan on the rate of cognitive decline in patients with arterial hypertension in the elderly and senile age. The features of the pharmacological characteristics of candesaratan that can remotely explain its clinical efficacy are considered. The data of experimental studies of candesartan in animals, which contribute to the concept of the possible effects of candesartan, are presented.
Adherence to taking medicines as a basis for prevention of cardiovascular diseases
Authors: Napalkov D. A. , Sokolova A. A.
Published: April 2019

The article discusses approaches to improving adherence to treatment with antihypertensive drugs and statins based on domestic and foreign experience, in particular, with the help of approaches proposed in the recommendations of the European Society of Cardiologists on Diagnostics and Treatment of Arterial Hypertension (ESC), updated in 2018. It is proposed to consider several levels to improve adherence: the level of the physician, the patient’s level, the level of prescription and the level of the healthcare system. The implementation of the principle of reducing the number of pills for the treatment of arterial hypertension can be achieved through the increased use of fixed combinations, such as lysinopril and prolonged action indapamide or lysinopril and amlodipine at the 1st stage of treatment selection. In the 2nd stage, a triple fixed combination of lysinopril, amlodipine and prolonged action indapamide can be used, thus maintaining the continuity of the therapy initiated. In patients with concomitant dyslipidemia, the authors suggest a fixed combination of lysinopril, amlodipine and rosuvastatin, which also improves adherence to statin therapy.
The choice of the P2Y12 receptors blocker in the treatment of a patient with acute coronary syndrome: practice of N.I. Pirogov city clinical hospital №1
Authors: Atabegashvili M. R. , Konstantinova E. V. , Kuznetsova V. A. , Sharaeva Ya. V. , Bogdanova A. A. , Gilyarov M. Yu.
Published: April 2019

Ticagrelor is known to prefer clopidigrel except in cases of high risk of bleeding, but according to the literature, clopidogrel still remains the most frequent second component of dual antiplatelet therapy (DAPT) in the world. The aim of the study was to conduct comparative description of patient groups with the acid acetilsalicilic (ACS), taken depending on a prescription of clopidogrel or ticagrelor as the second component of DAPT according to data of the year’s work of the Pirogov City Clinical Hospital №1. Materials and methods: clinical data of 854 patients with ACS who undergone treatment in of Pirogov City Clinical Hospital №1 in 2017 were analyzed. Clopidogrel was prescribed to 623 patients (73%) – the I group, ticagrelor 231 (27%) – the II group. Patients in the I group compared to the II group were significantly older (70 and 62 years accordingly), women accounted for 43% in I group and 27% in II group. Arterial hypertension (96 and 89%), diabetes (34 and 26%), post-acute myocardial infarction (38 and 19%), chronic kidney disease (26 and 12%), anemia (15 and 7%). Among patients of II group final diagnosis of ST-elevation myocardial infarction (STEMI) was more often (64 and 31%), coronary angiography (CAG) and percutaneous coronary intervention (PCI) were more frequent – 98/94% and 88/75%, accordingly. Clopidogrel is prescribed to the patients more often in comparison with ticagrelor. Doctors make a choice in favor of clopidogrel for elderly patients, more often women and more comorbid patients. The presence of STEMI, as well as the performance of CAG / PCI in any definitive diagnosis, is associated with a relatively more frequent prescription of ticagrelor, and in elderly patients, the implementation of PCI is the only factor that significantly influences the choice of more active antiaggregant in DAPT.
Peculiarities of the reaction of the lower limbs venous blood flow to the orthostatic test in men with arterial hypertension
Authors: Vagapov T. F. , Baev V. M. , Letyagina S. V.
Published: April 2019

A comparative analysis of the dynamics of lower limb vein angioscopy parameters in case of orthostasis between male patients (age 30–50 years) with arterial hypertension (test group – 60 people) and normal arterial pressure (control group – 27 people) was made. Orthostatic sample in all examined patients was characterized by a reliable increase in the diameter and area of vein section at a decrease in blood flow rate. However, in patients with hypertension the increase in the area of vein section was significantly less than in the control group. In orthostasis, the drop in blood flow rate in the total femoral vein was lower in men with hypertension than in men in the control group. In the great saphenous vein, a larger decrease in blood flow velocity was recorded than in the control group. In hypertension, no increase in the number of refluxes was recorded in orthostasis. Thus, hypertension in men is characterized by altered reaction of venous blood flow to orthostasis in both deep and saphenous veins.
Therapy of bacterial vaginosis
Authors: Marushkina O. I.
Published: April 2019

Aim:evaluation of efficacy of Multi-Gyn® Actigel application in the complex therapy of bacterial vaginosis (BV) and prevention of its recurrence in pregnant women.

Patients and methods:87 patients of reproductive age were examined and treated with the diagnosis of «bacterial vaginosis, chronic recurrent course». 41 of them from the main group were given Multi-Gyn® Actigel at the 1st stage of treatment, while 46 women of the comparison group were given 2% clindamycin cream In order to restore vaginal microbiocenosis, a probiotic containing Lactobacillus casei rhamnosus spp. LCR35 was used in both groups at the second stage Clinical laboratory methods were used.

Results:efficacy of Multi-Gyn® Actigel application in complex therapy of BV and prevention of its recurrences in non-pregnant women was proved. As a result of Multi-Gyn® Actigel prescription there were no complaints, pH level was normalized, almost complete absence of BV-associated microorganisms was achieved and lactobacillus pool preservation even in the distant period after treatment.

Conclusion:Multi-Gyn® Actigel is an effective remedy for treatment of BV and prevention of its recurrence in non-pregnant patients, especially in the chronic recurrent course of the disease. This effect is achieved not only by eliminating anaerobic microorganisms, but also due to the persistent preservation of the lactobacillus pool.
Prevention of recurrent endometrial pathology
Authors: Tikhomirov A. L. , Sarsania S. I. , Tuskayev K. S. , Yudina T. A.
Published: April 2019

Therapy resistance of endometrial pathology is one of the significant issues for gynaecologists facing this problem. The features of chronic endometritis include high prevalence of infertility and recurrent endomentrial process, due to adhesive process in the uterus. This task requires an integrated approach, including the use of modern anti-adhesive barrier containing hyaluronic acid and carboxymethylcellulose.
Optimization of multiple fillers used for removal of water pollutants of large well near the river in northern China
Authors: Gao Yanjiao , Li Shujie
Published: April 2019

In this paper, chromium (Cr(VI)), chemical oxygen demand (COD), and ammonia nitrogen in synthetically polluted well water were treated in three columns packed with different fillers to compare treatment effects. The concentrations of Cr(VI), COD, and ammonia nitrogen were used to investigate processing efficiency and find the most efficient column and fillers. Several effective fillers were scanned by a scanning electron microscope (SEM) with energy dispersive spectrometer (EDS) to discover the removing mechanism. Results showed No.1 column with iron powder, activated carbon, and artificial zeolite in series exerted the best ability to remove pollutants. Total removal rate of No.1 column for Cr(VI), COD, and ammonia nitrogen was 91.7%, 47.1%, and 81.6%, respectively. Iron powder removed 86.6% of Cr(VI), activated carbon removed 30.1% of COD, and artificial zeolite removed 66.9% of ammonia nitrogen. The ability of iron powder to remove Cr(VI) is attributed to the redox reaction between iron powder and Cr(VI). Removal of COD by activated carbon is based on the adsorption of activated carbon. Artificial zeolite contains a variety of cationic components and is capable of removing ammonia nitrogen from the water by ion exchange. The No.1 column process has higher reference values for the pretreatment of polluted well water in the towns of underdeveloped countries.
Optimization and mechanism of Acid Orange 7 removal by powdered activated carbon coupled with persulfate by response surface method
Authors: Wang Xuxu , Hu Xuebin , Zhao Chun , Sun Zhihua , Zheng Huaili , Li Junfeng , Wang Zhaoyang
Published: April 2019

In this study, powder activated carbon (PAC) utilized to activate peroxydisulfate (PDS) was investigated for decolorization of Acid Orange 7 (AO7). The results indicated a remarkable synergistic effect in the PAC/PDS system. The effect of PAC, PDS dosages and initial pH on AO7 decolorization were studied and the processes followed first-order kinetics. Response surface method with central composite design (CCD) model was utilized to optimize these three factors and analyze the combined interaction. The optimum condition for the decolorization rate of AO7 was analyzed as the following: PAC (0.19 g/L), PDS (1.64 g/L), and initial pH (4.14). Cl− and SO42− showed a promoting effect on AO7 decolorization while HCO3− had a slightly inhibiting effect. Quenching experiments confirmed that both sulfate and hydroxyl radicals were the oxidizing species, and the oxidation reaction occurred on the surface of PAC. The results of UV-vis spectrum with 100% decolorization rate and the 50% total organic carbon reduction indicated highly efficient decolorization and mineralization of AO7 in the PAC/PDS system. Finally, the recovery performance of PAC was studied and the result indicated PAC had poor reuse in reactivity.