bluuebunny/crossref_metadata_2025 huggingface dataset:
Upaya Menumbuhkan Kesehatan Mental Melalui Music Therapy Dalam Mengatasi Kecemasan
Authors: Zahrani Tsalisa Meiladia Zahrani , Ulin Nihayah  , Ayu Faiza Algifahmy
Published: July 2024

Penelitian ini bertujuan untuk mengetahui upaya menumbuhkan kesehatan mental melalui music therapy dalam mengatasi kecemasan. Sudah banyak ahli teori mengatakan bahwa terapy music juga dapat dilakukan dalam mengatasi gangguan kesehatan mental. metode yang digunakan yaitu metode kualitatif dengan pendekatan studi kasus yang dilakukan dengan wawancara kepada responden guna untuk menggali lebih dalam mengenai masalah-masalah yang akan diteliti oleh peneliti. Sehingga wawancara tersebut menghasilkan beberapa informasi terkait dengan judul yang sudah peniliti dapatkan antara lain:1) Therapy music sholawat berfungsi untuk menenangkan pikiran, 2) sholawat juga merupakan lantunan doa, 3) Musik sholawat juga dapat merelaksasi, sehingga individu dapat tertidur dengan suasana hati, jiwa yang tenang. Hasil dari penelitian ini menyatakan bahwa beberapa subjek yang mengalami gangguan kecemasan dapat teratasi dengan menggunakan therapy music religi salah satunya dengan terapi sholawat. Kesimpulan dalam penelitian yaitu terapi music sholawat dapat menumbuhkan Kesehatan mental bagi remaja yang sedang mengalami kecemasan.
Kata kunci: kecemasan, kesehatan mental, terapi musik
Pengaruh Konseling Kelompok Dengan Teknik Self Control Untuk Mengurangi Perilaku Menyontek Siswa Saat Ujian Di SMP Negeri 5 Karanganyar
Authors: Kusumawati Eny
Published: July 2024

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh layanan konseling kelompok teknik self control untuk mengurangi perilaku siswa saat ujian. Metode penelitian ini merupakan jenis eksperimen dan menggunakan one group pre-test post-test design dengan populasi penelitian yaitu siswa siswa kelas VIII F SMP Negeri 5 Karanganyar. dan penarikan sampel dilakukan dengan purposive sampling yang berjumlah 6 siswa. Teknik pengumpulan data dengan melakukan wawancara, angket (kuisioner), dan observasi. Analisis data yang dilakukan menggunakan Analisis Paired Sampel t-Test. Hasil dari penelitian ini adalah pelaksanaaan layanan konseling kelompok teknik self control dapat mengurangi perilaku menyontek siswa saat ujian. Hal ini dibuktikan berdasarkan analisis uji t (paired sample t-test) diperoleh bahwa thitung lebih besar dari ttabel yaitu 14.029 > 2.0150 dan Sig. (2- tailed) = 0,000 < 0,05. Hasil tersebut disimpulkan bahwa hipotesis Ho ditolak dan Ha diterima, pernyataan tersebut dapat dikatakan bahwa ada pengaruh layanan konseling kelompok teknik self control untuk mengurangi perilaku menyontek siswa kelas VIII F SMP Negeri 5 Karanganyar.
Kata kunci : konseling kelompok, teknik self control, perilaku menyontek
The Corelations of Loneliness with Social Media Addiction to Academic Procrastination in Adolescents
Authors: Isa Alvia  , Sri Saparahayuningsih  , Rita Sinthia
Published: July 2024

This study aims to determine the corrlation between loneliness and social media addiction to academic procrastination. The sampling technique used in this study is purposive sampling. The population of this study was all students of SMKN 3 Seluma with a total sample of 247 students taken based on predetermined criteria. Data were obtained through questionnaire distribution and analyzed using descriptive quantitative methods and analyzed using Product Moment test. The results showed that the loneliness variable had a positive influence on academic procrastination, which was 0.768, while the social media addiction variable had a positive effect on academic procrastination with a correlation coefficient value of 0.849 and loneliness had a significant positive effect on social media addiction with a correlation coefficient value of 0.767. So it can be concluded that loneliness and social media addiction have a significant positive corelation with academic procrastination.
Keywords: loneliness, social media addiction, academic procrastination
Analisis Tingkat Depresi Mahasiswa di Saat dan Sesudah Pandemi COVID-19
Authors: Maya Rahadian Septiningtyas
Published: July 2024

Terjadinya pandemi COVID-19 menimbulkan dampak negatif pada kesehatan mental di kalangan mahasiswa, yaitu depresi. Berubahnya kondisi dan situasi hidup menempatkan mahasiswa harus mampu menyesuaikan diri dengan cepat terhadap segala perubahan yang terjadi pada saat dan sesudah pandemi. Tujuan penelitian ini mendeskripsikan tingkat depresi pada mahasiswa di saat dan sesudah pandemi COVID-19. Tujuh puluh enam mahasiswa menyelesaikan Beck Depression Inventory (BDI) untuk mengukur depresi. Hasil penelitian menunjukkan bahwa sebanyak 24 mahasiswa (32%) yang mengalami depresi ringan, 24 orang (32%) pada kategori depresi sedang, dan 9 orang (12%) pada kategori berat. Hasil penelitian ini menunjukkan bahwa terjadi peningkatan jumlah mahasiswa yang mengalami depresi. Situasi pasca pandemi yang telah berangsur-angsur pulih ternyata tidak serta merta menurunkan tingkat depresi pada mahasiswa. Perubahan dan pengalaman yang terjadi saat pandemi COVID-19 memberi tekanan psikologis yang panjang pada mahasiswa hingga pandemi usai. Sehingga, terjadi peningkatan depresi pada mahasiswa di semua kategori, yaitu ringan, berat, dan sedang.
Kata kunci: depresi, mahasiswa, pandemi
Efektivitas Competence and Worthiness Training (CWT) pada Siswa Sekolah Menengah Pertama (SMP) dengan Low Self-Esteem
Authors: Winesa Sekar Aulia , Rifameutia Tjut
Published: July 2024

Studi dilakukan pada seorang remaja perempuan berusia 14 tahun yang diketahui memiliki pandangan diri yang kurang adekuat. Subjek cenderung mengkritik diri dan membandingkan diri dengan orang lain sehingga membutuhkan intervensi untuk meningkatkan self-esteem agar subjek dapat memandang diri lebih positif dan mampu menghadapi tantangan sehari-hari. Penelitian ini meneliti efektivitas Competence and Worthiness Training (CWT) untuk meningkatkan self-esteem pada subjek. CWT dilihat sebagai program yang sesuai untuk kebutuhan partisipan. Metode penelitian menggunakan single-subject A-B design dengan melihat perubahan self-esteem sebelum dan sesudah dilakukan intervensi CWT. Hasil penelitian menunjukkan bahwa CWT berhasil meningkatkan self-esteem X sebesar 20% dan menunjukkan perubahan perilaku positif di sekolah dan di rumah. Berdasarkan hasil penelitian, intervensi CWT dapat membantu remaja untuk mengembangkan self-esteem. Temuan ini dapat digunakan untuk mengembangkan program intervensi dalam membantu remaja dengan self-esteem rendah.
Kata kunci: competence and worthiness training, intervensi, psikoedukasi, self-esteem
Hubungan Antara Harga Diri (Self Esteem) Dengan Perilaku Agresif Pada Siswa Sekolah Menengah Kejuruan (SMK)
Authors: Oktafia Ika , Maria Nugraheni Mardi Rahayu
Published: July 2024

Penelitian ini bertujuan untuk mengetahui hubungan antara harga diri (self esteem) dengan perilaku agresif pada siswa SMK “X” di Salatiga. Jenis penelitian yang digunakan merupakan penelitian kuantitatif dengan desain korelasional. Teknik pengambilan data menggunakan 2 skala yaitu skala The Aggression Questionnaire untuk mengukur perilaku agresif dan skala Self Competence Self Liking (SCSL) yang diadaptasi dari aspek harga diri. Partisipan dalam penelitian ini berjumlah 79 siswa laki-laki dan 120 siswa perempuan SMK “X” di Salatiga. Teknik analisis data menggunakan metode korelasi Product Moment dari Karl Pearson. Hasil analisis korelasi pada penelitian ini sebesar (r) -0,539 dan nilai p sebesar 0,000. Berdasarkan hasil penelitian terdapat hubungan negatif antara harga diri dengan perilaku agresif pada siswa SMK “X” di Salatiga. Semakin tinggi harga diri, maka semakin rendah perilaku agresif. Sebaliknya, semakin rendah harga diri semakin tinggi perilaku agresif yang dilakukan. Kesimpulannya bahwa harga diri sangat berdampak pada perilaku agresif remaja.
Kata kunci: perilaku agresif, harga diri, remaja
Resiliensi Dan Subjective Well-Being Pada Mahasiswa Difabel Di Indonesia
Authors: Padang Rindu Rosa Hadelina , Huwae Arthur
Published: July 2024

Tujuan penelitian ini untuk mengetahui hubungan antara resiliensi dan subjective well-being pada mahasiswa difabel di Indonesia. Metode yang digunakan adalah kuantitatif korelasional. Sebanyak 102 mahasiswa difabel di Indonesia yang menjadi partisipan dengan menggunakan teknik snowball sampling. Pengukuran penelitian menggunakan Connor-Davidson Resilience Scale (CD-RISC), Satisfaction With Life Scale (SWLS), dan Positive Affect Negative Affect Schedule (PANAS). Hasil uji hipotesis dengan Spearman Rho’ diperoleh nilai r sebesar 0,696 dan sig. = 0,000 (p<0,01), yang berarti hipotesis diterima. Hasil ini berarti bahwa ketika terjadi peningkatan atau penurunan resiliensi, maka akan diikuti dengan peningkatan atau penurunan subjective well-being pada mahasiswa difabel di Indonesia. Dengan demikian, resiliensi dapat dijadikan sebagai sarana atau strategi mental oleh setiap mahasiswa difabel agar memudahkan diri sendiri dalam mencapai subjective well-being di kehidupan akademik maupun aktivitas hidup sehari-hari.
Kata kunci: resiliensi, subjective well-being, mahasiswa difabel
Metode Bimbingan Agama Orang Tua Asuh Dalam Membangun Percaya Diri Pada Remaja Putri Panti Asuhan
Authors: Khairani Ulfa , Zainun
Published: July 2024

Penelitian ini dilatarbelakangi oleh kurangnya rasa kepercayaan diri yang dimiliki oleh remaja putri di panti asuhan Muhammadiyah, karena rasa percaya diri harus dimiliki oleh setiap remaja dalam perkembangan kepribadiannya. Tujuan penelitian ini adalah untuk mengetahui bagaimana metode bimbingan agama yang diterapkan oleh orang tua asuh dan faktor penghambat yang terjadi saat diterapkannya metode bimbingan agama. Metode penelitian yang digunakan merupakan penelitian kualitatif deskriptif. Dalam teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Lokasi penelitian dilakukan di panti asuhan Muhammadiyah Asahan dengan informan penelitian adalah orang tua asuh dan 5 remaja panti asuhan yang berusia 15-18 tahun. Hasil penelitian mengungkapkan bahwa remaja yang diberikan metode bimbingan agama melalui metode ceramah berupa nasihat dan motivasi dapat menjadi lebih percaya diri dengan kemampuan dan keyakinan pada dirinya. Kesimpulan penelitian ini metode bimbingan agama membantu para remaja dalam membangun percaya diri, sehingga mengetahui potensi yang dimiliki dan mampu dalam mengatasi permasalahan yang dialaminya.
Kata kunci: metode bimbingan agama, orang tua asuh, percaya diri
Hubungan Antara Dukungan Keluarga Dengan Tingkat Kecemasan Mahasiswa Yang Sedang Mengerjakan Skripsi
Authors: Bagus Wicaksono  , Ratriana Yuliastuti Endang Kusumiati
Published: July 2024

Penelitian ini bertujuan untuk mengetahui hubungan antara dukungan keluarga dengan tingkat kecemasan. Penelitian dilakukan terhadap 78 mahasiswa akhir program sarjana fakultas psikologi angkatan 2020 yang sedang menempuh tugas akhir atau skripsi dan diperoleh melalui teknik simple random sampling. Penelitian ini menggunakan instrumen Hamilton Anxiety Rating Scale (HARS) untuk mengukur tingkat kecemasan dan Perceived Social Support Family (PSS-Fa) untuk mengukur dukungan keluarga yang dianalisis menggunakan uji Spearman. Hasil penelitian diperoleh nilai koefisien r = -0,360 dan p = 0,001 (p < 0,05), menunjukkan bahwa ada hubungan negatif yang signifikan antara dukungan keluarga dengan tingkat kecemasan. Semakin tinggi dukungan keluarga maka semakin rendah tingkat kecemasan. Sebaliknya, semakin rendah dukungan keluarga maka semakin tinggi tingkat kecemasan. Kesimpulan dalam penelitian ini bahwa terdapat hubungan negatif yang signifikan antara dukungan keluarga dengan tingkat kecemasan pada mahasiswa yang sedang mengerjakan skripsi angkatan 2020 Fakultas Psikologi Universitas Kristen Satya Wacana.
Kata kunci: dukungan keluarga, kecemasan, mahasiswa, skripsi
Consumer Behavior Analysis Approach to Teacher Choice of Reading Interventions
Authors:   , Picardo Rochelle
Published: July 2024

The use of Evidence-based Practices (EBPs) in schools is heavily emphasized in educational research and policy; however, many teachers do not use EBPs for reading instruction and intervention. Previous research on the limited use of EBPs in classrooms has primarily focused on teacher characteristics, such as their attitudes or beliefs toward these practices. As an alternative to this view, this study applied a behavioral economic approach to understanding teacher choice (i.e., EBPs over other alternatives, such as interventions with a base of limited empirical support; low-value practices [LVPs]). Hypothetical Intervention Choice Tasks were developed and used to evaluate how both utilitarian reinforcement (UR; evidence of effectiveness) and informational reinforcement (IR; support from the verbal/social community) contingencies influence small-group reading intervention choices (Tier 2). Study participants were teachers who have provided Tier 2 supplemental reading intervention for school-age students. Study participants were recruited using a Qualtrics® panel. Results indicated that teachers demonstrated substitutability of EBPs for reading intervention with alternatives regardless of whether those alternatives had evidence of efficacy. Results of this study contribute to the limited body of literature on the ecological factors that influence teacher choices regarding the consumption of EBPs for reading.
"Pressure and Rate Transient Analyses for Plume Characterization and Storage Capacity Estimation of CO2 Storage Projects"
Authors:   , Abdelaal Mohamed
Published: July 2024

"Reservoir characterization is a key factor for effective management of commercial-scale Geologic CO2 Storage (GCS) projects. Pressure/rate transient analyses (PTA/RTA) have evolved as reliable tools for assessing hydrocarbon and GCS reservoirs. Injection rate and pressure data are routinely measured as a part of GCS projects’ surveillance, or during transient well testing. The data contain valuable information about the subsurface that can be extracted. The extracted information enables the operator to evaluate the effectiveness of injection operations, and to make remedial/corrective interventions. In this current work, different analytical and numerical techniques are presented to characterize, assess, and maximize the economic and volumetric value of the target formations devoted for CO2 storage. The objectives of this study are achieved through developing novel analytical models that describe the evolution of bottomhole pressure during or after CO2 injection at a constant-rate. The analytical models are derived through solving the governing equations that describe CO2-brine flow in the reservoir. The models are solved using rigorous mathematical techniques considering simplifying assumptions about rock and fluid properties. Based on the developed analytical models, graphical interpretation methodologies are introduced to analyze injection rate and pressure data using PTA and RTA techniques. The analytical models and the interpretation methodologies are validated against numerical simulations and real field datasets to demonstrate their robustness and practical application. The simulations are conducted on representative geological models using commercial reservoir simulation tools. Results indicate that the interpretation methodologies can be reliably utilized to (1) infer the fluid mobilities and radial extent of the CO2 dry-out zone to assess CO2 injectivity, (2) monitor the spatial-temporal evolution of CO2 plume to constrain CO2 in the designated storage area, and (3) predict the ultimate storage capacity of a target formation to assess the feasibility of the GCS project to accommodate the large supply of CO2. Then, to maximize the economic and volumetric value of a given fixed pore space, simulations studies are performed to investigate the factors that affect CO2 injectivity and subsequent storage capacity. This includes investigating the injection well operating conditions, and physical processes controlling CO2 distribution around the injection well."
Who’s Afraid of Red, Yellow and Blue: On the Ukrainian Abstract Art of the 1960s
Authors: Sklyarenko Galyna
Published: July 2024

The paper focuses on the creative experiments of Ukrainian artists during the 1960s in the field of abstract art, analyzing them against the background of social and cultural events of the time, which were reflected in the features of artistic life. In this regard, Western fine art revealed to Ukrainian artists during the years of the Thaw after decades of strict separation from foreign art during the Stalinist era, was a profound influence on them. However, the perception of the Western experience was rather specific due to the lack of information and theoretical understanding of the latest trends, as most works of world art became known in Ukraine through the exhibitions in Moscow and printed reproductions. The ambiguity of the cultural policy in the USSR played a significant role here, where the official declaration of the renewal of art and the right of artists to individual self-expression were combined with a new ideological attack on creativity. State control over art gained new dimensions, due to which the authors’ experiments in the realm of abstract painting were doomed to exist in the circle of unofficial art. The article examines the “campaign against abstractionism and Western influences” launched by the authorities in the early 1960s, which had a dramatic impact on individual creative destinies.
Using the example of artists from Lviv, Kyiv, Kharkiv, Odesa, and Uzhgorod, the article analyzes creative directions in the realm of painterly abstraction, the features of its versions in Ukraine. It is significant that in most cases the appeal to non-figurative art remained only an episode in the work of artists, or coexisted with other ways of figurative expression. Abstract art in Ukraine generally was experimental, the presence of similar works in the art of the late Soviet era testified to a deep crisis of the socialist realist doctrine, the affirmation of individual creative thinking. Abstract works of Ukrainian artists of the 1960s are an important page in the history of Ukrainian art.
At a High Price: Global Recognition of Ukrainian Graphic Design
Authors: Danylenko Lesya , Danylenko Victor
Published: July 2024

The article provides data on the increase of the activity of the Ukrainian graphic design abroad after the full-scale invasion of Russian troops in Ukraine. The process of increasing of the international contacts of Ukrainian graphic design is highlighted. This is revealed on the examples of the exhibition activities of the leading art educational institutions and other institutions of Ukraine as well as on the results of the participation of the Ukrainian graphic designers in various international competitions.
The materials of the exhibitions in Germany, Austria, Poland, Great Britain, France were analyzed. The results of the competitions held by the world printing organization The Type Directors Club, the international competition Novum Design Award, the UK logo competition are presented. It also provides the data on the dynamic growth of the support from many countries to the Ukrainian graphic artists in the form of grants, programs for the creation of art projects, scholarships, etc.
It is emphasized that along with the emergence of a large number of immigrants from Ukraine in many countries, there was an increase in the presence of the Ukrainian professionals, who found employment abroad in the field of graphic design and students who enrolled in the foreign universities.
At such a high cost of the tragedy of the war, Ukraine had paid for the recognition of Ukrainian graphic design in the world.
Ukrainian Scenography at the Beginning of the 21st Century: Algorithms of Existence—Essential Meanings
Authors: Kovalchuk Olena
Published: July 2024

The article identifies the main trends in the development of Ukrainian scenography of the beginning of the 21st century, which are implemented by th artists of the national theatre in the complex reality and historical contexts. The author analyses aspects of psychological reformatting of Ukrainian scenography, the artists’ creative guidelines reevaluation under the influence of war and their ability to fully implement their ideas in the formats of theatrical performances, in the space of exhibition projects, installation performance practices formats, in easel works and teaching. The paper studies the projects’ conceptual characteristics and targets of Mariya Levytska, Andrii Aleksandrovych-Dochevskyi, Lyudmila Nagorna, Sergiy and Natalya Rydvanetskis, Bogdan Polishchuk, Inessa Kulchytska, Oleg Tatarynov, Yulia Zaulichana, Olesya Holovach, Olena Polishchuk, and other artists. The author defines the theatre artists’ positions in critical moments of Ukrainian history, identifies the figurative characteristics of the participants’ project installations as manifestations of the artists’ style and the phenomenon of artistic response to the Russian-Ukrainian war and analyses the main participants’ features of the creative development in artistic processes and their role in the evolution of scenography culture in Ukraine. Highlighted is the extraordinary role of theatre artists of the early 21st century as the successors of the national scenography school leading development concepts, in whose creative projects national consciousness is manifested and clearly defined constantly gravitating towards European values.
Open Form, Its Psychological, Civilizational, and Aesthetic Foundations in the Works of Modern Ukrainian Artists
Authors: Petrova Olga
Published: July 2024

The paper presents the concept of an “open work” (according to the idea of Umberto Eco) as a meaningfully undefined, and even non-finito work, which appeared in the artistic practice of the 20th century, at the time of revolutionary and military disasters. The events of the early 20th century in the social, psychological, and artistic consciousness of the leading avant-garde figures caused emotional and psychological shifts and contributed to the emergence of new ways of artistic expression. In art, works with different vector characteristics emerged: palimpsest, simulacrum, deconstruction, etc. Since then, the nature of general development of art became that of a rhizome. Similar principles of artistic thinking were predicted by H. Wölfflin in art (19th century) and in the aesthetics by A. Schopenhauer, F. Nietzsche, A. Bergson, and other philosophers of the early 20th century. The aesthetic concept of an “open work” and its special poetics reoriented the European art critics’ opinions regarding the analysis of modern artistic practice. Art studies focused on the artistic form in the very process of its formation (incompleteness). The process of forming an artistic work became the subject of meticulous analysis as something that is interesting to the modern viewer, who is a “synergistic person.” In the context of the poetics of an “open work,” the paper highlights the significance of the avant-garde discoveries of Oleksandr Arkhipenko as a pioneer of world modern sculpture. The connection of his philosophical and plastic thinking with dynamic social and scientific shifts in the life of mankind, with the “physics of space” of Albert Einstein, is visualized. The revolutionary role of caesuras (voids) in the volumes of Archipenko sculpture is defined. Under the angle of the concept of an “open work,” the article visualizes new forms of dialogue between modernists of the 21st century, in particular, Ukrainian artists and their recipients. The analysis of the works of modern Ukrainian artists (O. Zhyvotkov, O. Dzhuraeva, I. Grechanyk) illustrates the practical use of an “open form” as a modern practice in the time of psychological tension and uncertainty, in the state of stressful situations of the 2022–2024 war in Ukraine. “Staying before nothingness” (K. Jaspers’s expression), life on the threshold of existence caused irrationalism and “poetics of incompleteness” in the works of the mentioned artists. It was important to determine such a substantial characteristic of the work as ambiguity in its perception and reading. The paper reveals the psychological and plastic foundations of the authors’ artistic thinking when producing an “open work.” The productivity of a certain artistic paradigm is proven.
Technological Art: History of the Concept and Its Interpretation
Authors: Tymofiienko Bohdan
Published: July 2024

The article examines the interdisciplinary nature of technological art, which involves the interaction of art, science, and technology. It discusses the impact of rapid technological development on the socio-cultural landscape of the world, as well as the modification of our perception of the surrounding environment. The main focus is on the history of the concept of “technological art”, which encompasses the evolution of the interplay between art and technology from mechanical through digital media to virtual and augmented reality technologies.
Various interpretations of this concept are considered, particularly in the works of Frank Popper, who highlights the shift in aesthetics in the digital age, Paul Virilio’s critical view of technologies through their destructive impact on society, and Edward A. Shanken, who sees new perspectives for creativity in technological art. Jill Fantauzza notes a certain tension between technological art and traditional art, while Ellen Perlman speaks of two different directions in the functioning of technological art — the first aimed at integrating cutting-edge technologies as a form of artistic expression with the actualization of philosophical ideas, and the second direction aimed at inclusive engagement of a broad audience, presenting technological innovations with an entertainment or educational purpose.
The author concludes that technological art should be viewed not only as a category of art that uses technological tools but as a broader reflection of the process of integrating the latest achievements into artistic processes, affecting the socio-cultural landscape. By combining aesthetic, conceptual, and technological dimensions, technological art fosters the emergence of new forms of art, expanding the arsenal of artists with new methods.
Overexpression of Mammaglobin-A in Primary Breast Tissue Tumor and High Concentration of mRNA Mammaglobin-A in Peripheral Blood as Risk Factors for Metastatic Breast Cancer
Authors: Suryawisesa Ida Bagus Made , Manuaba Ida Bagus Tjakra Wibawa
Published: July 2024

Objective: There is still limited evidence for the use of biomarkers in breast cancer. However, mammaglobin-A in tissue and blood has recently been found as a promising biomarker for detecting metastases. Therefore, this study will examine the overexpression of mammaglobin-A in primary breast tissue tumors and the elevated concentration of mammaglobin-A messenger RNA (mRNA0 in peripheral blood as potential risk factors for breast cancer metastasis.
Methods: The study was conducted at Sanglah General Hospital in Bali, Indonesia, from July 2017 to March 2018. It employed a hybrid research design, combining both cross-sectional (n = 70) and case-control (metastasis = 20 and non-metastasis = 20) approaches. Peripheral blood samples were collected using specialized L6 tubes and were analyzed for the expression of mammaglobin-A mRNA using quantitative real-time PCR. The diagnosis of breast cancer was established through open biopsy, considered the gold standard. Biopsy specimens underwent histopathological examination and standard immunohistochemistry (IHC) analysis to assess ER, PR, HER2, and Ki67 markers. The evaluation of mammaglobin-A protein expression was conducted via IHC at the Anatomical Pathology Laboratory of Prima Medika Hospital.
Result: The mean mammaglobin-A mRNA level in the metastatic group was 11.59±1.37, while in the non-metastatic group was 8.17±1.27-fold change relative to the housekeeping gene beta microglobulin. The mean mammaglobin-A mRNA levels in the two groups were significantly different (p<0.05). Overexpression of mammaglobin-A in cancer tissue was 7.36 times more likely for metastasis compared to non-metastatic (OR = 7.36; 95% CI = 1.34-40.55; p = 0.013). Additionally, mammaglobin-A mRNA concentration was found to be nine times higher for breast cancer metastasis compared to the non-metastatic group (OR = 9.00; 95% CI = 2.15-37.66; p = 0.002).
Conclusion: The mean mammaglobin-A level in the metastatic group significantly differs from that in the non-metastatic group. Overexpression of mammaglobin-A and a high concentration of Mammaglobin-A mRNA are influential risk factors for metastatic breast cancer.
Cancer Care in Elderly Patients; A Record Based Retrospective Analysis of Clinical Profile and Overview of Treatment
Authors: Panikkar Drishya S , Narayanan Geeta S , BR Kiran Kumar
Published: July 2024

Background and Objective: Cancer can develop at any age, but the incidence of cancer rises dramatically at a later stage in life. Cancer management in older people can be complex. Comorbidity and Physiologic age-related changes can affect how and when cancer is diagnosed, whether or not treatment is offered and the individual tolerance to anticancer therapy. This retrospective study aimed to assess the clinical profiles of elderly cancer patient to optimize cancer care. Materials and Methods: This retrospective study comprised cancer patients attended our oncology department between 2018 to 2022 who were above the age ≥65 years. All the information regarding the type of cancer, performance status, intent of treatment, treatment completion and follow up status at 3 years were documented and analyzed. Results: A total of 230 patients were included in the study. The common malignancies were Carcinoma Head and Neck and Lung Cancer followed by Esophagus and Colorectal malignancies. Most of the patients presented with Performance Status of 1 (57.8%). The intent of therapy was curative in 49.1% and Palliative in 30.1% patients. At median follow up 36 months 15% of treated patients were on regular follow-up and they were alive without disease. Conclusion: Head and Neck Cancer was the most common cancer seen in our study. Elderly patients with cancer presented with good performance status, hence Elderly Cancer patients deserve same opportunity as younger patients for treatment and survival options.
The Application of Polybutyl Cyanoacrylate (PBCA) Nanoparticles in Delivering Cancer Drugs
Authors: Salehi Vahid , Izadkhah Mohaddeseh , Salehi Hanifeh , Sadeghi Pour Niki , Ghanbarikondori Parizad
Published: July 2024

Overview: Cancer remains a significant global health challenge, accounting for one in eight deaths worldwide. Chemotherapy, the primary cancer treatment, is often limited by drug resistance. Optimizing therapy procedures has been suggested to improve survival and quality of life for cancer patients, including those with drug resistance. In recent years, nanotechnology has garnered significant attention for its potential in cancer treatment. Nanoparticles (NPs) are widely utilized to enhance therapeutic outcomes by improving drug bioavailability, solubility, and retention time. NPs offer essential conditions for targeted drug delivery through various delivery systems, including microcapsules or NPs. Polybutyl cyanoacrylate (PBCA) is among the most commonly used carriers for drug delivery in cancer treatment, with several studies investigating its efficacy.
Methods: This article aims to review the effectiveness of PBCA as a drug delivery system in the treatment of various cancers.
Results: Several studies have utilized PBCA for drug delivery in cancer treatment, indicating its potential efficacy in this regard.
Conclusion: The review highlights the potential of PBCA as a promising drug delivery system for the treatment of different types of cancer.
A Case of Dynamic Molecular Profile in Metastatic Lung Adenocarcinoma and the Significance of Multiple-site Testing
Authors: Paturu Radha , Lingaiah Raghavendra , Singh Shalini , Kumari Niraj , Krishnani Narendra
Published: July 2024

Lung adenocarcinomas show intratumoral heterogeneity which has significant impact on the selection of targeted therapy. Multiple molecular sub-clones coexist within an individual tumour which determine recurrence and metastasis formation which is often under-evaluated in a single-site needle biopsy. Our case report demonstrates this intriguing phenomenon and the importance of multiple-site molecular testing to determine the dominant molecular alteration, and initiating the appropriate targeted therapy for better prognosis. Molecular testing from accessible metastatic sites in lung cancer is recommended for a complete assessment of prognosis and therapeutic options in recurrent and metastatic disease.
A Comparative Study of Palliative Hypo-fractionated vs Conventional Fractionated Radiotherapy in Locally Advanced Non Small Cell Lung Cancer
Authors: Dhaka Saroj , Sihag Rakesh Kumar , Saharan Vidushi , Dhaka Shankar Singh , Beniwal Surender
Published: July 2024

Purpose: To compare the compliance, tumor response, quality of life and survival between a hypo-fractionated and a conventional fractionated RT schedule in locally advanced NSCLC patients.
Materials and Methods: Total 50 patients with unresectable stage III NSCLC were given 3 cycle of neoadjuvant chemotherapy. After 3-4 weeks of completion of 3rd cycle, 25 patients received a total 17Gy in 2 fr (8.5Gy/fr) on day 1 and day 8 in study arm, 25 patients received a total 50 Gy in 25 fr (2Gy/fr) administered daily (5days/week) for 5 weeks. Disease response was evaluated by RECIST criteria at 1, 3 and 6 month. Then follow up was done after 1yr, 2yr and 3yr to evaluate the overall survival.
Result: none of patients in both arms had complete response at any follow up. Locoregional disease control was observed in 18% & 27% in study and control arm respectively (p value>0.05). Median survival was 10 months and 12.5 months in study and control arm respectively which was not statistically significant. There was no statistically difference in grade of toxicities. OS rates at 1, 2 and 3years were 40%, 10% and 0% in study arm and 50%, 20% and 5% in control arm but difference in OS was not statistically significant.
Conclusion: Many patients were lost to follow up in our study; although among the patients followed, we found to concluded that for improvement of quality of life in locally advanced NSCLC patients with poor PS and short life span, the palliative hypo-fractionated regimen of short duration (17Gy/2fr) could be considered as a reasonable alternative and also economically feasible & required shorter duration of stay in the hospital. In conclusion, large number of patients with strict follow up need to be done to ascertain the need and benefits of this palliative TRT.
Treatment Outcomes of Stereotactic Body Radiotherapy for Early-stage Non-small Cell Lung Cancer and Lung Metastasis
Authors: K M.D. Boonyawan , T M.D. Nanna , P M.D. Puataweepong , T M.D. Suwatanapongched
Published: July 2024

Background and rationale: Stereotactic body radiotherapy (SBRT) is a highly precise localized high-dose per fraction radiation treatment used mainly in lung cancer. Despite SBRT's increasing use, no clear predictive factors of outcome exist.
Objectives: To report local control rates, patterns of failure, and incidence of treatment-related toxicity, and to determine factors predicting SBRT outcomes for primary and secondary lung tumors at Ramathibodi Hospital using competing risk analysis.
Materials and methods: This retrospective study included all patients diagnosed with primary early non-small cell lung cancer (NSCLC) and lung metastasis in our radiosurgery and radiotherapy database registry between January 2009 and September 2018.
Results: Fifty-nine patients (98 lung tumors) were studied; primary NSCLC and lung metastasis were 15.3% and 84.7%, respectively. Median follow-up was 16.8 months. The overall 1-year local control rate was 90.8%. The most common pattern of failure was distant failure (46.9%). The incidence of radiation pneumonitis (RP) grade ≥2 was 9.2%, and one of four patients with an ultra-central tumor developed grade 5 pulmonary toxicity. The predictive factor for local failure was the mean biological equivalent dose (BED) of the planning target volume (PTV), and for RP grade ≥2, the tumor's maximal diameter. BED PTV mean <100 Gy had higher local failure than BED PTV mean ≥100 Gy (adjusted subdistribution hazard ratio 8.26; 95% confidence interval (CI) 1.76–38.68, p=0.007). Patients with tumors with maximal diameters ≥5 cm compared with those with maximal diameters <5 cm had more RP grade ≥2 (adjusted subdistribution hazard ratio 5.34; 95% CI 1.52–18.69, p=0.009). The overall 1-year survival rate was 73.5%.
Conclusions: Local control of lung tumors using SBRT was high with acceptable toxicity. BED PTV mean was a local control predictor. Large tumors correlated with symptomatic RP grade ≥2. SBRT should be used judiciously for ultra-central lung tumors.
Constipation - A Disregarded Symptom in Patients Undergoing Radiotherapy for Head and Neck Cancer – A Clinical Audit on Management
Authors: Krishnamurthy Sapna , Ahmed Imtiaz
Published: July 2024

Background: In clinical practice, constipation in patients undergoing Radiotherapy (RT) for head and neck cancer is not only very common, but many a times left unattended. Unrelieved constipation results in patient distress and poor compliance to treatment. Most of the patients are empirically treated with poor symptom control. The aim of this audit was to find out the burden of constipation and to treat them effectively.
Methods: Standard based clinical audit was undertaken in the department of Radiation Oncology from July 2021 to January 2022, in patients with complaints of constipation who are undergoing RT for head and neck cancers. The intervention planned (criteria) was to follow the European Society for Medical Oncology (ESMO) 2018 flowchart for the management of constipation, which were divided into 4 checkpoints for the ease of quantification – 1. history taken, 2. documentation of type of laxative used, 3. review for symptom relief and 4. maintenance therapy prescription. The standard set was 65%.
Results: A total of 48 patients in the initial assessment (retrospective) and 44 patients in the re-assessment (prospective) were evaluated. The mean age in both the audit was 54 years, 32 (66.6%) patients in the initial assessment and 26 (60%) patients in the re-assessment reported constipation during RT. Comparing the pre intervention and post intervention, the 4 checkpoints of the ESMO flowchart were never addressed (0%) as compared to 92%, 92%, 77% and 77% respectively. The mean number of days for complete symptom relief were 7 v/s 2 days respectively. Mean number of days to report constipation was 5 days v/s 3 days respectively. The mean number of active reviews till complete symptom relief was 0 v/s 2 times.
Conclusion: Empirical management of constipation occurring during RT for head and neck cancers gives poor results. Guideline based treatment help manage the constipation better thus enhancing the patient care.
Breast Carcinoma with Isolated Orbital Metastasis –A Rare Clinical Entity
Authors: Sahni Manish , Mehta Harsha N , Gothwal Ravindra , Lakhera Kamal Kishor , Singh Suresh
Published: July 2024

Breast cancer with isolated orbital metastasis is a rare clinical entity.We hereby present a rare case report of 35 year old premenopausal lady with known case of carcinoma breast right side (operated for right modified radical mastectomy in year 2017 with final histopathology of pT2N2M0, hormone receptor-positive and Her2-negative disease). She completed adjuvant 8 cycles of standard dose chemotherapy with 4 cycles of Cyclophosphamide, Adriamycin followed by 4 cycles of Paclitaxel followed by local Radiation therapy. She was initiated Tab. Tamoxifen 20 mg once daily and was continued same for 4 years when in July 2021, she complained of sudden decreased visual acuity and diplopia of right eye lasting from last 1 month. Ophthalmological examination confirmed the findings with decreased visual acuity of 6/36 of right eye while visual acuity of left eye was normal. CT scan of orbits revealed 28 × 18mm heterogeneous enhancing soft tissue mass in right orbital compartment,extrabulbar, occupying postero-superior quadrant inseparable from lateral rectus muscle with optic nerve effacement. PET-CT scan was performed which revealed no metastasis elsewhere in the body. She was offered surgical oophorectomy followed by switch to another hormonal therapy of aromatase inhibitors. She showed complete response to treatment and is now disease from last 2 years.
Perbedaan Skor Kualitas Hidup pada Subjek Usia Dewasa dengan Hipertensi dan Non-Hipertensi di Wilayah Kerja Puskesmas Tampaksiring I
Authors: Sari Made Harlina Purnama , Permatananda Pande Ayu Naya Kasih , Suyasa I Putu Gede Eka Ariawan , Aryastuti Anak Agung Sri Agung
Published: July 2024

Hipertensi merupakan kondisi ketika tekanan darah sistolik (TDS) seseorang mencapai ≥ 140 mmHg dan/atau tekanan diastolik (TDD) sebesar  ≥ 90 mmHg pada pengukuran berulang di klinik. Gejala-gejala dari hipertensi dapat mengganggu aktivitas sehari-hari, sehingga hal tersebut dapat berpengaruh kepada kualitas hidup penderita hipertensi. Penelitian ini bertujuan untuk menganalisis perbedaan skor kualitas hidup pada subjek usia dewasa dengan hipertensi dan non-hipertensi di wilayah kerja Puskesmas Tampaksiring I. Penelitian ini menggunakan penelitian observasional analitik dengan desain cross sectional. Pada penelitian ini diharapkan diperoleh responden sebanyak 92 orang dengan sebaran 46 responden usia dewasa dengan hipertensi dan 46 responden usia dewasa non-hipertensi. Data yang digunakan adalah data primer yang diperoleh melalui pengisian langsung kuesioner WHOQOL-BREF untuk mengetahui tingkat kualitas hidup. Analisis data dilakukan secara univariat dan bivariat menggunakan uji Mann-Whitney U Test. Hasil analisis univariat didapatkan mayoritas subjek penelitian berusia 40-60 tahun (72,8%), berjenis kelamin perempuan (57,6%), bependidikan tinggi (56,5%), dan status bekerja (80,4%). Hasil analisis bivariat didapatkan nilai p = 0,000 yang menunjukkan bahwa terdapat perbedaan bermakna signifikan (p < 0,05), sehingga dapat ditarik kesimpulan bahwa terdapat perbedaan skor kualitas hidup pada subjek usia dewasa dengan hipertensi dan non-hipertensi di wilayah kerja Puskesmas Tampaksiring I.
Pengaruh Penyuluhan Kesehatan Terhadap Tingkat Pengetahuan Siswa Siswi Perguruan Islami Amalia Mengenai Pencegahan Dan Pengendalian Vektor Penyakit Demam Berdarah Dengue
Authors: Nanda Meutia , Handaris Purba Anisa Fitri , Nur Asia Esni Siti , Okta Wiranika Dedek Sania , Gultom Khairunnisa , Harahap Sefira Aulia , Widyana Widyana , Harahap Suhail
Published: July 2024

Demam Berdarah Dengue (DBD) merupakan salah satu penyakit menular yang perlu diberi perhatian lebih, karena semakin banyaknya kasus menyebar luas di Indonesia. Provinsi Sumatera Utara merupakan wilayah yang tergolong cukup banyak memiliki kasus penyakit demam berdarah dengue (DBD) dengan jumlah 2.923 kasus. Kelompok usia dengan risiko tertinggi tertular penyakit demam berdarah dengue (DBD) adalah usia anak-anak yang masih berada dibawah 15 tahun. Peningkatan pengetahuan diyakini akan berpengaruh pada peningkatan sikap anak sekolah untuk mencegah munculnya penyakit demam berdarah dengue (DBD) di lingkungan sekitarnya. Penelitian ini bertujuan untuk meningkatkan pengetahuan siswa-siswi mengenai pencegahan dan pengendalian vektor penyakit demam berdarah dengue (DBD). Jenis penelitian adalah kuantitatif menggunakan desain Quasi Experiment dengan rancangan One Group Pre Test dan Post Test. Penelitian dilakukan pada bulan Oktober 2023 di Perguruan Islam Amalia, Kecamatan Medan Denai, Kota Medan, Provinsi Sumatera Utara. Populasi penelitian adalah seluruh siswa-siswi kelas VII tahun ajaran 2023/2024. Teknik pengambilan sampel adalah Purposive Sampling sebanyak 30 siswa/i. Analisis data menggunakan uji statistik Paired Samples T-Test untuk mengetahui perbedaan nilai rata-rata sebelum dan setelah penyuluhan menggunakan program SPSS dengan nilai α = 0,05. Hasil penelitian diketahui bahwa terdapat perbedaan tingkat pengetahuan responden sebelum dan setelah penyuluhan. Sebelum diberikan penyuluhan, masih banyak responden memiliki pengetahuan yang cukup. Setelah diberikan penyuluhan, banyak responden memiliki pengetahuan yang baik.
Faktor Yang Mempengaruhi Peminatan Metode Implan Di Desa Awang Bangkal Barat Kecamatan Karang Intan Kabupaten Banjar
Authors: Munada Laily , Sajidah Ainun , Mahdalena Mahdalena , Mariana Evi Risa
Published: July 2024

Banyak perempuan yang mengalami kesulitan dalam menentukan pilihan jenis kontrasepsi. Hal ini tidak hanya karena terbatasnya metode yang tersedia. Tujuan penelitian untuk mengetahui faktor yang mempengaruhi peminatan metode KB imlpan di desa Awang Bangkal Barat Kecamatan Karang Intan Kabupaten Banjar. Rancangan penelitian ini menggunakan noneksperimen penelitian deskriptif dengan pendekatan Cross Sectional. Teknik pengambilan sampel adalah Simplerandom sampling. Sampel kasus pada penelitian ini adalah Akseptor KB di Desa Awang Bangkal Barat Tahun 2021 sebanyak 87 responden. Analisa data menggunakn chi-square dengan instrument  kuesioner. Hasil penelitian didapatkan adalah umur ibu sebanyak 62.1%, pengetahuan yang kurang sebanyak 40.2%, efek samping sebagai faktor tidak berminat pada implan ada 59.8%, dan dukungan suami 60.9%. Hasil uji statistik menunjukkan ada hubungan hubungan umur (ρ=0,000), pengetahuan (ρ= 0,000), efek samping (ρ= 0,000)  dan dukungan suami (ρ= 0,000) dengan minat peserta KB Implan. Kesimpulannya ada hubungan yang signifikan antara umur, pengetahuan, efek samping dan dukungan suami terhadap minat menggunakan KB Implan di Desa Awang Bangkal Barat tahun 2021. Sarannya diharapkan mendapatkan wawasan pengetahuan lebih banyak tentang Metode KB Implan
Analisis Perbandingan Kinerja Keuangan Perusahaan Jasa Pengiriman Sebelum dan Saat Pandemi Covid-19
Authors: Fitriawan Syahadat Edy , Kurniawan Agus , Taliwuna Dian Christiani
Published: July 2024

Tujuan penelitian ini untuk mengetahui kinerja perusahaan jasa pengiriman sebelum dan saat penyebaran wabah Covid-19 dengan menggunakan metode komparatif historis dan metode analisis komparatif relasional. Metode komparatif historis membandingkan data rata-rata Current Ratio (CR), Debt to Equity Ratio (DER), Asset Turn Over (ATO), dan Return on Equity (ROE) sebelum Penyebaran wabah dan saat penyebaran wabah, untuk mengetahui apakah performa financial perusahaan meningkat atau menurun. Sedangkan metode analisis komparatif relasional dengan membandingkan antara rasio kinerja perusahaan tahun 2020 dan rasio standar rata-rata industri untuk mengetahui kinerja perusahaan pada saat Penyebaran wabah apakah berkinerja baik atau buruk. Populasi penelitian adalah 30 perusahaan di Bursa Efek Indone sia pada sektor transportasi dan logistik. Pengambilan sample menggunakan teknik purposive sampling. Berdasarkan hasil analisis komparatif historis, tingkat rata-rata rasio likuiditas, dan rasio profitabilitas performa finansial perusahaan jasa pengiriman saat terjadinya Penyebaran wabah Covid-19 tahun 2020 mengalami penurunan dikomparasikan dengan sebelum terjadinya Penyebaran wabah Covid-19 tahun 2018. Sedangkan untuk rasio solvabilitas, dan rasio aktivitas, pada saat Penyebaran wabah Covid-19 Tahun 2020 mengalami peningkatan dikomparasikan sebelum Penyebaran wabah Covid-19 tahun 2018, Kemudian secara komparatif relasional, rata-rata rasio likuiditas, solvabilitas, aktivitas dan profitabilitas perusahaan dikomparasikan dengan standar rasio rata-rata industri tahun 2020 dapat dikatakan kurang efisien (buruk) karena kesemuanya berada dibawah standar rasio rata-rata industri.