bluuebunny/crossref_metadata_2025 huggingface dataset:
A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi
Authors: Berk Jason M. , Lim Christopher , Ronau Judith A. , Chaudhuri Apala , Chen Hongli , Beckmann John F. , Loria J. Patrick , Xiong Yong , Hochstrasser Mark
Published: May 2020

Ubiquitin mediated signaling contributes critically to host cell defenses during pathogen infection. Many pathogens manipulate the ubiquitin system to evade these defenses. Here we characterize a likely effector protein bearing a deubiquitylase (DUB) domain from the obligate intracellular bacterium Orientia tsutsugamushi, the causative agent of scrub typhus. The Ulp1-like DUB prefers ubiquitin substrates over ubiquitin-like proteins and efficiently cleaves polyubiquitin chains of three or more ubiquitins. The co-crystal structure of the DUB (OtDUB) domain with ubiquitin revealed three bound ubiquitins: one engages the S1 site, the second binds an S2 site contributing to chain specificity and the third binds a unique ubiquitin-binding domain (UBD). The UBD modulates OtDUB activity, undergoes a pronounced structural transition upon binding ubiquitin, and binds monoubiquitin with an unprecedented ~5 nM dissociation constant. The characterization and high-resolution structure determination of this enzyme should aid in its development as a drug target to counter Orientia infections.
A mechanistic account of serotonin’s impact on mood
Authors: Michely Jochen , Eldar Eran , Martin Ingrid M. , Dolan Raymond J.
Published: May 2020

Selective serotonin reuptake inhibitors (SSRIs) constitute a first-line antidepressant intervention, though the precise cognitive and computational mechanisms that explain treatment response remain elusive. Using week-long SSRI treatment in healthy volunteer participants, we show serotonin enhances the impact of experimentally induced positive affect on learning of novel, and reconsolidation of previously learned, reward associations. Computational modelling indicated these effects are best accounted for by a boost in subjective reward perception during learning, following a positive, but not negative, mood induction. Thus, instead of influencing affect or reward sensitivity directly, SSRIs might amplify an interaction between the two, giving rise to a delayed mood response. We suggest this modulation of affect-learning dynamics may explain the evolution of a gradual mood improvement seen with these agents and provides a novel candidate mechanism for the unfolding of serotonin’s antidepressant effects over time.
Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer
Authors: Ge Jennifer Y. , Shu Shaokun , Kwon Mijung , Jovanović Bojana , Murphy Katherine , Gulvady Anushree , Fassl Anne , Trinh Anne , Kuang Yanan , Heavey Grace A. , Luoma Adrienne , Paweletz Cloud , Thorner Aaron R. , Wucherpfennig Kai W. , Qi Jun , Brown Myles , Sicinski Piotr , McDonald Thomas O. , Pellman David , Michor Franziska , Polyak Kornelia
Published: May 2020

BET inhibitors are promising therapeutic agents for the treatment of triple-negative breast cancer (TNBC), but the rapid emergence of resistance necessitates investigation of combination therapies and their effects on tumor evolution. Here, we show that palbociclib, a CDK4/6 inhibitor, and paclitaxel, a microtubule inhibitor, synergize with the BET inhibitor JQ1 in TNBC lines. High-complexity DNA barcoding and mathematical modeling indicate a high rate of de novo acquired resistance to these drugs relative to pre-existing resistance. We demonstrate that the combination of JQ1 and palbociclib induces cell division errors, which can increase the chance of developing aneuploidy. Characterizing acquired resistance to combination treatment at a single cell level shows heterogeneous mechanisms including activation of G1-S and senescence pathways. Our results establish a rationale for further investigation of combined BET and CDK4/6 inhibition in TNBC and suggest novel mechanisms of action for these drugs and new vulnerabilities in cells after emergence of resistance.
ORF Capture-Seq as a versatile method for targeted identification of full-length isoforms
Authors: Sheynkman Gloria M. , Tuttle Katharine S. , Laval Florent , Tseng Elizabeth , Underwood Jason G. , Yu Liang , Dong Da , Smith Melissa L. , Sebra Robert , Willems Luc , Hao Tong , Calderwood Michael A. , Hill David E. , Vidal Marc
Published: May 2020

Most human protein-coding genes are expressed as multiple isoforms, which greatly expands the functional repertoire of the encoded proteome. While at least one reliable open reading frame (ORF) model has been assigned for every coding gene, the majority of alternative isoforms remains uncharacterized due to (i) vast differences of overall levels between different isoforms expressed from common genes, and (ii) the difficulty of obtaining full-length transcript sequences. Here, we present ORF Capture-Seq (OCS), a flexible method that addresses both challenges for targeted full-length isoform sequencing applications using collections of cloned ORFs as probes. As a proof-of-concept, we show that an OCS pipeline focused on genes coding for transcription factors increases isoform detection by an order of magnitude when compared to unenriched samples. In short, OCS enables rapid discovery of isoforms from custom-selected genes and will accelerate mapping of the human transcriptome.
Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
Authors: Di Tano Maira , Raucci Franca , Vernieri Claudio , Caffa Irene , Buono Roberta , Fanti Maura , Brandhorst Sebastian , Curigliano Giuseppe , Nencioni Alessio , de Braud Filippo , Longo Valter D.
Published: May 2020

Fasting-mimicking diets delay tumor progression and sensitize a wide range of tumors to chemotherapy, but their therapeutic potential in combination with non-cytotoxic compounds is poorly understood. Here we show that vitamin C anticancer activity is limited by the up-regulation of the stress-inducible protein heme-oxygenase-1. The fasting-mimicking diet selectivity reverses vitamin C-induced up-regulation of heme-oxygenase-1 and ferritin in KRAS-mutant cancer cells, consequently increasing reactive iron, oxygen species, and cell death; an effect further potentiated by chemotherapy. In support of a potential role of ferritin in colorectal cancer progression, an analysis of The Cancer Genome Atlas Database indicates that KRAS mutated colorectal cancer patients with low intratumor ferritin mRNA levels display longer 3- and 5-year overall survival. Collectively, our data indicate that the combination of a fasting-mimicking diet and vitamin C represents a promising low toxicity intervention to be tested in randomized clinical trials against colorectal cancer and possibly other KRAS mutated tumors.
Interventions to improve medication adherence in tuberculosis patients: a systematic review of randomized controlled studies
Authors: Pradipta Ivan S. , Houtsma Daphne , van Boven Job F. M. , Alffenaar Jan-Willem C. , Hak Eelko
Published: May 2020

Non-adherence to anti-tuberculosis (anti-TB) medication is a major risk factor for poor treatment outcomes. We therefore assessed the effectiveness of medication adherence enhancing interventions in TB patients. We report a systematic review of randomized controlled trials that included either latent tuberculosis infection (LTBI) or active TB patients. Outcomes of interest included adherence rate, completed treatment, defaulted treatment and treatment outcomes. We identified four LTBI and ten active TB studies. In active TB patients, directly observed treatment (DOT) by trained community workers, short messaging service combined with education, counselling, monthly TB vouchers, drug box reminders and combinations of those were found effective. In LTBI patients, shorter regimens and DOT effectively improved treatment completion. Interestingly, DOT showed variable effectiveness, highlighting that implementation, population and setting may play important roles. Since non-adherence factors are patient-specific, personalized interventions are required to enhance the impact of a programme to improve medication adherence in TB patients.
H7N9 influenza split vaccine with SWE oil-in-water adjuvant greatly enhances cross-reactive humoral immunity and protection against severe pneumonia in ferrets
Authors: de Jonge Jørgen , van Dijken Harry , de Heij Femke , Spijkers Sanne , Mouthaan Justin , de Jong Rineke , Roholl Paul , Adami Eduardo Alfredo , Akamatsu Milena Apetito , Ho Paulo Lee , Brunner Livia , Collin Nicolas , Friede Martin , Ferreira José A. , Luytjes Willem
Published: May 2020

Until universal influenza vaccines become available, pandemic preparedness should include developing classical vaccines against potential pandemic influenza subtypes. We here show that addition of SWE adjuvant, a squalene-in-water emulsion, to H7N9 split influenza vaccine clearly enhanced functional antibody responses in ferrets. These were cross-reactive against H7N9 strains from different lineages and newly emerged H7N9 variants. Both vaccine formulations protected in almost all cases against severe pneumonia induced by intratracheal infection of ferrets with H7N9 influenza; however, the SWE adjuvant enhanced protection against virus replication and disease. Correlation analysis and curve fitting showed that both VN- and NI-titers were better predictors for protection than HI-titers. Moreover, we show that novel algorithms can assist in better interpretation of large data sets generated in preclinical studies. Cluster analysis showed that the adjuvanted vaccine results in robust immunity and protection, whereas the response to the non-adjuvanted vaccine is heterogeneous, such that the protection balance may be more easily tipped toward severe disease. Finally, cluster analysis indicated that the dose-sparing capacity of the adjuvant is at least a factor six, which greatly increases vaccine availability in a pandemic situation.
CoryneRegNet 7, the reference database and analysis platform for corynebacterial gene regulatory networks
Authors: Parise Mariana Teixeira Dornelles , Parise Doglas , Kato Rodrigo Bentes , Pauling Josch Konstantin , Tauch Andreas , Azevedo Vasco Ariston de Carvalho , Baumbach Jan
Published: May 2020

We present the newest version of CoryneRegNet, the reference database for corynebacterial regulatory interactions, available at www.exbio.wzw.tum.de/coryneregnet/. The exponential growth of next-generation sequencing data in recent years has allowed a better understanding of bacterial molecular mechanisms. Transcriptional regulation is one of the most important mechanisms for bacterial adaptation and survival. These mechanisms may be understood via an organism’s network of regulatory interactions. Although the Corynebacterium genus is important in medical, veterinary and biotechnological research, little is known concerning the transcriptional regulation of these bacteria. Here, we unravel transcriptional regulatory networks (TRNs) for 224 corynebacterial strains by utilizing genome-scale transfer of TRNs from four model organisms and assigning statistical significance values to all predicted regulations. As a result, the number of corynebacterial strains with TRNs increased twenty times and the back-end and front-end were reimplemented to support new features as well as future database growth. CoryneRegNet 7 is the largest TRN database for the Corynebacterium genus and aids in elucidating transcriptional mechanisms enabling adaptation, survival and infection.
Pofatu, a curated and open-access database for geochemical sourcing of archaeological materials
Authors: Hermann Aymeric , Forkel Robert , McAlister Andrew , Cruickshank Arden , Golitko Mark , Kneebone Brendan , McCoy Mark , Reepmeyer Christian , Sheppard Peter , Sinton John , Weisler Marshall
Published: May 2020

Compositional analyses have long been used to determine the geological sources of artefacts. Geochemical “fingerprinting” of artefacts and sources is the most effective way to reconstruct strategies of raw material and artefact procurement, exchange or interaction systems, and mobility patterns during prehistory. The efficacy and popularity of geochemical sourcing has led to many projects using various analytical techniques to produce independent datasets. In order to facilitate access to this growing body of data and to promote comparability and reproducibility in provenance studies, we designedPofatu, the first online and open-access database to present geochemical compositions and contextual information for archaeological sources and artefacts in a form that can be readily accessed by the scientific community. This relational database currently contains 7759 individual samples from archaeological sites and geological sources across the Pacific Islands. Each sample is comprehensively documented and includes elemental and isotopic compositions, detailed archaeological provenance, and supporting analytical metadata, such as sampling processes, analytical procedures, and quality control.
Author Correction: How wind drives the correlation between leaf shape and mechanical properties
Authors: Louf Jean-François , Nelson Logan , Kang Hosung , Ntoh Song Pierre , Zehnbauer Tim , Jung Sunghwan
Published: May 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Quantum random number generators with entanglement for public randomness testing
Authors: Jacak Janusz E. , Jacak Witold A. , Donderowicz Wojciech A. , Jacak Lucjan
Published: May 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes
Authors: Callaghan Neal I. , Lee Shin-Haw , Hadipour-Lakmehsari Sina , Lee Xavier A. , Ahsan Siraj M. , Driouchi Amine , Yip Christopher M. , Husain Mansoor , Simmons Craig A. , Gramolini Anthony O.
Published: May 2020

Primary adult cardiomyocyte (aCM) represent the mature form of myocytes found in the adult heart. However, culture of aCMs in particular is challenged by poor survival and loss of phenotype, rendering extended in vitro experiments unfeasible. Here, we establish murine aCM culture methods that enhance survival and maintain sarcomeric structure and Ca2+ cycling to enable physiologically relevant contractile force measurements. We also demonstrate genetic and small-molecule manipulations that probe mechanisms underlying myocyte functional performance. Together, these refinements to aCM culture present a toolbox with which to advance our understanding of myocardial physiology.
Pd-catalyzed fluoro-carbonylation of aryl, vinyl, and heteroaryl iodides using 2-(difluoromethoxy)-5-nitropyridine
Authors: Liang Yumeng , Zhao Zhengyu , Shibata Norio
Published: May 2020

Acyl fluorides have recently gained a lot of attention as robust and versatile synthetic tools in synthetic chemistry. While several synthetic routes to acyl fluorides have been reported, a procedure involving direct insertion of the “fluoro-carbonyl” moiety using a single reagent has not yet been realized. Here we report the preparation of acyl fluorides by palladium-catalyzed fluoro-carbonylation of aryl, vinyl, and heteroaryl iodides using 2-(difluoromethoxy)-5-nitropyridine under CO-free conditions. 2-(difluoromethoxy)-5-nitropyridine is a stable, colorless solid that can be used as an alternative to the toxic gaseous formyl fluoride, which is commonly used under fluoride catalysis conditions. A wide variety of acyl fluorides are efficiently and safely obtained in high yield (up to 99%). A broad range of functional groups is tolerated under the optimized reaction conditions and the method can be applied to the late-stage fluoro-carbonylation of structurally complex Csp2-iodides, including bioactive derivatives, such as Fenofibrate, Isoxepac, and Tocopherol. Furthermore, the one-pot transformation of aryl-iodides, including drug-like molecules, into the corresponding amides by successive fluoro-carbonylation/amidation reactions, demonstrates the potential synthetic utility of this strategy.
Oral processing and comfort perception of soft cereal foods fortified with pulse proteins in the elderly with different oral health status
Authors: Assad-Bustillos M. , Tournier C. , Palier J. , Septier C. , Feron G. , Della Valle G.
Published: May 2020

Variations of bolus properties (viscosity) with saliva for pulse proteins fortified cereal foods with (B = brioche, SC = sponge cake).
Nanomaterial-based multiplex optical sensors
Authors: Pei Xiaojing , Tao Guangyu , Wu Xi , Ma Yurou , Li Rongsheng , Li Na
Published: May 2020

Multiplexed detections based on optical nanomaterials.
Three-dimensional hydrogen distribution and quantitative determination of titanium alloysvianeutron tomography
Authors: Yang Lixia , He Linfeng , Huang Danqi , Wang Yaoqi , Song Quanwei , Zhao Lei , Shen Xuejing , Tian Zhiling , Wang Haizhou
Published: May 2020

For the first time, neutron tomography was applied for 3D quantitative hydrogen distribution analysis in titanium alloys following thermohydrogen processing.
A novel analytical principle using AP site-mediated T7 RNA polymerase transcription regulation for sensing uracil-DNA glycosylase activity
Authors: Gao Weichen , Xu Jin , Lian Guowei , Wang Xiaojun , Gong Xiaoqun , Zhou Dianming , Chang Jin
Published: May 2020

udgactivity could regulateT7 RNApolymerase transcription ability by the heteroduplex substrates with chemical modifications.
A new hybrid nanocomposite electrode based on Au/CeO2-decorated functionalized glassy carbon microspheres for the voltammetric sensing of quercetin and its interaction with DNA
Authors: Ibrahim Mohamed , Ibrahim Hossieny , Almandil Noor B. , Sayed Marwa A. , Kawde Abdel-Nasser
Published: May 2020

A new hybrid composite containing cerium oxide nanoparticles (CeO2NPs) and gold nanoparticles (AuNPs)-decorated functionalized glassy carbon microspheres (FGCM) was synthesized (Au/CeO2@FGCM) and used for voltammetric sensing of quercetin.
Light-enhanced hypoxia-responsive and azobenzene cleavage-triggered size-shrinkable micelles for synergistic photodynamic therapy and chemotherapy
Authors: Xu Zhangting , Pan Chang , Yuan Weizhong
Published: May 2020

The micelles self-assembled from POEGMA-b-PCL-Azo-PCL-b-POEGMA present light-enhanced hypoxia-responsive and azobenzene cleavage-triggered size-shrinkable properties for synergistic photodynamic therapy and chemotherapy.
Tailorable hierarchical structures of biomimetic hydroxyapatite micro/nano particles promoting endocytosis and osteogenic differentiation of stem cells
Authors: Xu Dong , Wan Yuxin , Li Zhihao , Wang Chunbao , Zou Qingxia , Du Chang , Wang Yingjun
Published: May 2020

Hydroxyapatite (HA) micro/nano particles show great promise as artificial bone and dental substitutes, or drug carrier systems.
Single-layer carbon-coated FeCo alloy nanoparticles embedded in single-walled carbon nanotubes for high oxygen electrocatalysis
Authors: Xie Dengyu , Chen Yu , Yu Deshuang , Han Silin , Song Junnan , Xie Yaoyi , Hu Feng , Li Linlin , Peng Shengjie
Published: May 2020

Novel and durable single-layer carbon-coated FeCo alloy nanoparticles embedded in single-walled carbon nanotubes exhibit remarkable oxygen electrocatalysis, which advances realistic rechargeable zinc–air batteries with high efficiency.
Unusually large fluorescence quantum yield for a near-infrared emitting DNA-stabilized silver nanocluster
Authors: Neacşu Vlad A. , Cerretani Cecilia , Liisberg Mikkel B. , Swasey Steven M. , Gwinn Elisabeth G. , Copp Stacy M. , Vosch Tom
Published: May 2020

Silver nanoclusters stabilized by 5′-CCCGGAGAAG-3′ DNA strands display an unusually high fluorescence quantum yield in the near-infrared region.
Near-infrared photothermal conversion of stable radicals photoinduced from a viologen-based coordination polymer
Authors: Wang Shanshan , Li Shuning , Xiong Junyu , Lin Zhengguo , Wei Wei , Xu Yanqing
Published: May 2020

A highly stable radical photoinduced from a viologen-based coordination polymer exhibited a remarkable near-infrared photothermal effect with good recyclability.
Janus amphiphilic nanoplatelets as smart colloid surfactants with complementary face-to-face interactions
Authors: Lee Jin Yong , Choi Kyu Hwan , Hwang Jaemin , Sung Minchul , Kim Ji Eun , Park Bum Jun , Kim Jin Woong
Published: May 2020

A new type of colloidal surfactant that not only has a nanoscale platelet geometry, but can also induce complementary face-to-face interactions among Pickering emulsion droplets is introduced.
Dipyridinoarsole: a new class of stable and modifiable heteroatom-bridged bipyridines
Authors: Fujii Toshiki , Tanaka Susumu , Hayashi Shotaro , Imoto Hiroaki , Naka Kensuke
Published: May 2020

Dipyridinoarsole, having high air-stability and electrochemical reversibility, has been experimentally and computationally studied. The chemical structure was selectively modified to tune the absorption and emission wavelengths and to realize electrochromism.
Tailoring the preferable orientation relationship and shape of α-FeSi2 nanocrystals on Si(001): the impact of gold and the Si/Fe flux ratio, and the origin of α/Si boundaries
Authors: Tarasov Ivan A. , Smolyarova Tatiana E. , Nemtsev Ivan V. , Yakovlev Ivan A. , Volochaev Mikhail N. , Solovyov Leonid A. , Varnakov Sergey N. , Ovchinnikov Sergey G.
Published: May 2020

An approach for tuning the preferable orientation relationships and shapes of free-standing α-FeSi2 nanocrystals was demonstrated on a Si(001) surface.
First principles calculations on order and disorder in La2Ce2O7 and Nd2Ce2O7
Authors: Kalland Liv-Elisif , Mohn Chris E.
Published: May 2020

Intimacy between collective ion transport and local structure is a key to understanding poorly understood Ln2Ce2O7 to design future SOFCs.
Pressure-induced isostructural phase transition in Ti3AlC2: experimental and theoretical investigation
Authors: Li Yan , Ye Meiyan , Tang Ruilian , Chen Jiuhua , Qu Xin , Yang Bin , Wang Xin , Yue Huijuan , Zhu Pinwen
Published: May 2020

A pressure-induced isostructural phase transition was detected around 20 GPa in Ti3AlC2.
Reactivity and rotational spectra: the old concept of substitution effects
Authors: Herbers Sven , Buschmann Philipp , Wang Juan , Lengsfeld Kevin Gregor , Nair K. P. Rajappan , Grabow Jens-Uwe
Published: May 2020

The internal rotation of methyl groups and nuclear quadrupole moments of the halogens Cl, Br, I ino-halotoluenes result in complex spectral fine and hyperfine structures in rotational spectra which can be related to qualitative concepts in chemistry.
Nature and evolution of Pd catalysts supported on activated carbon fibers during the catalytic reduction of bromate in water
Authors: Cerrillo Jose L. , Lopes Christian W. , Rey Fernando , Agostini Giovanni , Kiwi-Minsker Lioubov , Palomares Antonio E.
Published: May 2020

Pd/ACF are active catalysts for the bromate reduction and their activity depends on the Pd crystal size with a pseudo-first order kinetic respect to BrO3− and H2 partial pressure.
Pushing the limits of activity and stability: the effects of Lewis acids on non-heme iron–NHC epoxidation catalysts
Authors: Dyckhoff Florian , Schlagintweit Jonas F. , Reich Robert M. , Kühn Fritz E.
Published: May 2020

Tetradentate iron–NHC complexes exhibit unprecedented activity (TOF: 410 000 h−1) in the epoxidation of cis-cyclooctene by addition of Lewis acids.
Rhenium in the core of porphyrin and rhenium bound to the periphery of porphyrin: synthesis and applications
Authors: Majumder Smita , Borah Bishnu Prasad , Bhuyan Jagannath
Published: May 2020

An overview of most of the well known rhenium porphyrins is presented reviewing their synthesis, coordination chemistry, and applications. The chemistry of some recently known porphyrin-Re conjugates is also discussed.
Synthesis of π-extended B ← N coordinated phenanthroimidazole dimers and their linear and nonlinear optical properties
Authors: Vanga Mukundam , Sa Shreenibasa , Kumari Anupa , Murali Anna Chandrasekar , Nayak Prakash , Das Ritwick , Venkatasubbaiah Krishnan
Published: May 2020

B ← N coordinated phenanthroimidazole dimers exhibit excellent fluorescence quantum yields in solution and conjugation length dependant two-photon-absorption properties.
Immobilization of N-oxide functionality into NbO-type MOFs for significantly enhanced C2H2/CH4 and CO2/CH4 separations
Authors: Xu Tingting , Fan Lihui , Jiang Zhenzhen , Zhou Ping , Li Ziruo , Lu Huangyan , He Yabing
Published: May 2020

Two NbO-type MOFs with N-oxide functionality immobilized in the pore surface display significantly enhanced C2H2/CH4 and CO2/CH4 separation performance.
Li2(Se2O5)(H2O)1.5·CuCl2, a salt-inclusion diselenite structurally based on tetranuclear Li4 complexes
Authors: Markovski Mishel R. , Siidra Oleg I. , Charkin Dmitri O. , Vladimirova Victoria A. , Tsirlin Alexander A. , Grishaev Vasili Yu.
Published: May 2020

A new lithium copper diselenite chloride hydrate, Li2Se2O5(H2O)1.5·CuCl2, was prepared from aqueous solution.
H-Bonded and metal(ii)–organic architectures assembled from an unexplored aromatic tricarboxylic acid: structural variety and functional properties
Authors: Gu Jin-Zhong , Wan Shi-Mao , Kirillova Marina V. , Kirillov Alexander M.
Published: May 2020

2,5-Di(4-carboxylphenyl)nicotinic acid was explored as a novel building block for assembling nine metal(ii) coordination compounds; these were fully characterized and their structural features and functional properties were investigated.
Conformation controlled stepwise hydride shuffling from the metal to the ligand backbone
Authors: Wiedmaier Nicholas R. , Speth Hansjörg , Leistikow Georg , Eichele Klaus , Schubert Hartmut , Mayer Hermann A. , Wesemann Lars
Published: May 2020

The protonation of the benzo annulated cycloheptatriene PCP pincer ruthenium hydrido dicarbonyl complex using the superacid [H(Et2O)2][BArF24] launches a cascade of hydride shifts which lead to the hydrogenation of the ligand backbone.
Ageing remarkably alters the toxicity of carbon black particles towards susceptible cells: determined by differential changes of surface oxygen groups
Authors: Wei Shuting , Qi Yu , Ma Li , Liu Yongchun , Li Guangke , Sang Nan , Liu Sijin , Liu Yajun
Published: May 2020

Ageing process remarkably alters the toxicity of carbon black particles towards susceptible cells via changing the species of their surface oxygen groups.
Inhibitory mechanism of epicatechin gallate on tyrosinase: inhibitory interaction, conformational change and computational simulation
Authors: Song Xin , Hu Xing , Zhang Ying , Pan Junhui , Gong Deming , Zhang Guowen
Published: May 2020

Epicatechin gallate can inhibit the activity of tyrosinase in a mixed-type manner.
(−)-Epicatechin mitigates high fat diet-induced neuroinflammation and altered behavior in mice
Authors: Kang Jiye , Wang Ziwei , Oteiza Patricia I.
Published: May 2020

(−)-Epicatechin improves memory in high fat diet-induced obese mice in association with prevention of endotoxemia and mitigation of neuroinflammation.
Lactobacillus casei LH23 modulates the immune response and ameliorates DSS-induced colitis via suppressing JNK/p-38 signal pathways and enhancing histone H3K9 acetylation
Authors: Liu Meiling , Ding Jinhua , Zhang Hongmin , Shen Jing , Hao Yunpeng , Zhang Xiuxia , Qi Wei , Luo Xuegang , Zhang Tongcun , Wang Nan
Published: May 2020

Probiotics are thought to have immunomodulatory functions, improve inflammatory disorders and treat inflammatory bowel disease (IBD).
A minimal constraint device for imaging nuclei in liveDrosophilacontractile larval muscles reveals novel nuclear mechanical dynamics
Authors: Lorber Dana , Rotkopf Ron , Volk Talila
Published: May 2020

Muscle contractions produce reiterated cytoplasmic mechanical variations, which potentially influence nuclear mechanotransduction, however information regarding the dynamics of muscle nuclei in the course of muscle contraction is still missing.
Real structure micromodels based on reservoir rocks for enhanced oil recovery (EOR) applications
Authors: Gaol Calvin Lumban , Wegner Jonas , Ganzer Leonhard
Published: May 2020

In this work, an attempt to close gaps between micromodels and reservoir rocks was performed by constructing chips based on the X-ray micro-computed tomography (μCT) images of a Bentheimer core plug.
The surfactant-free bottom-up synthesis of ultrathin MOF nanosheets for the oxidation of isoeugenol to vanillin
Authors: Srinivasapriyan Vijayan
Published: May 2020

The direct synthesis of ultrathin MOF nanosheets is extremely challenging. Existing methods suffer from structural deterioration, aggregation, morphological fragmentation, and low yields. The direct synthesis of MOF nanosheets remains a challenging task.
The stability of a graphene oxide (GO) nanofiltration (NF) membrane in an aqueous environment: progress and challenges
Authors: Wang Zhenxing , He Fang , Guo Jing , Peng Shaoqin , Cheng Xi Quan , Zhang Yingjie , Drioli Enrico , Figoli Alberto , Li Yuexiang , Shao Lu
Published: May 2020

The progress and challenges in achieving the stability of a graphene oxide nanofiltration membrane in an aqueous environment have been reviewed and explored.
Experimental and theoretical investigations of the effect of heteroatom-doped carbon microsphere supports on the stability and storage capacity of nano-Co3O4 conversion anodes for application in lithium-ion batteries
Authors: Dwivedi Pravin K. , Nair Aathira , Mehare Rupali S. , Chaturvedi Vikash , Joshi Kavita , Shelke Manjusha V.
Published: May 2020

An experimental and computational study of nanocomposite anodes comprising Co3O4 nanoparticles decorated on nitrogen and sulphur co-doped carbon spheres for appliction in LIBs.
Cyanostilbene-based vapo-fluorochromic supramolecular assemblies for reversible 3D code encryption
Authors: Gao Zhao , Chen Ze , Han Yifei , Wang Feng
Published: May 2020

Vapo-fluorochromic 3D code encryption systems have been constructed on the basis of cyanostilbene-based supramolecular assemblies, which open up a new avenue toward smart information protection materials.
ZnSnO3–hBN nanocomposite-based piezocatalyst: ultrasound assisted reactive oxygen species generation for degradation of organic pollutants
Authors: Biswas Aritra , Saha Subhajit , Jana Nikhil R.
Published: May 2020

Ultrasound assisted sustainable degradation of RhB by a lead-free ferroelectric ZnSnO3–hBN piezocatalyst.
Construction of a family of Ln3 clusters using multidentate Schiff base and β-diketonate ligands: fluorescence properties, magnetocaloric effect and slow magnetic relaxation
Authors: Wang Wen-Min , Gao Yu , Yue Rong-Xin , Qiao Na , Wang Dan-Tong , Shi Ying , Zhang Huan , Cui Jian-Zhong
Published: May 2020

Seven μ-Oacylhydrazone-bridged Ln3 clusters were synthesized. Cluster 3 displayed magnetic refrigeration properties, whereas cluster 5 showed slow magnetic relaxation. The solid-state fluorescence properties of 2, 4 and 5 were also studied.
A biocompatible phosphorescent Ir(iii) oxygen sensor functionalized with oligo(ethylene glycol) groups: synthesis, photophysics and application in PLIM experiments
Authors: Kritchenkov Ilya S. , Elistratova Anastasiia A. , Sokolov Viktor V. , Chelushkin Pavel S. , Shirmanova Marina V. , Lukina Maria M. , Dudenkova Varvara V. , Shcheslavskiy Vladislav I. , Kalinina Sviatlana , Reeß Kirsten , Rück Angelika , Tunik Sergey P.
Published: May 2020

NIR emitting Ir(iii) complexes decorated with oligo(ethylene glycol) were used to assess the degree of hypoxia in biosamples.
Thermodynamic and kinetic studies of the antiradical activity of 5-hydroxymethylfurfural: computational insights
Authors: Boulebd Houssem , Mechler Adam , Hoa Nguyen Thi , Vo Quan V.
Published: May 2020

The antiradical properties of 5-HMF in the gas-phase and in physiological environments were examined by thermodynamic and kinetic calculations.
Surface modification of all-inorganic halide perovskite nanorods by a microscale hydrophobic zeolite for stable and sensitive laser humidity sensing
Authors: Li Ruxue , Yu Jiahao , Wang Sheng , Shi Yueqing , Wang Zhaojin , Wang Kai , Ni Zhenhua , Yang Xuyong , Wei Zhipeng , Chen Rui
Published: May 2020

CsPbBr3 nanorods modified by hydrophobic zeolite exhibits high stability and enhanced scattering that allowing for high quality random lasing. Using lasing rather than photoluminescence as humidity sensing signal makes the sensing more reliable.
Charge doping induced reversible multistep structural phase transitions and electromechanical actuation in two-dimensional 1T′-MoS2
Authors: Chen Kaiyun , Deng Junkai , Shi Qian , Ding Xiangdong , Sun Jun , Yang Sen , Liu Jefferson Zhe
Published: May 2020

Charge doping could effectively modulate the charge density wave state of monolayer MoS2 with large strain output and superelasticity.
Influence of rare earth metal Ho on the interfacial Dzyaloshinskii–Moriya interaction and spin torque efficiency in Pt/Co/Ho multilayers
Authors: Liu Long , Zhao Xiaotian , Liu Wei , Song Yuhang , Zhao Xinguo , Zhang Zhidong
Published: May 2020

In this work, we found that the interfacial Dzyaloshinskii-Moriya interaction (DMI) and SOT in Pt/Co/Ho multilayers can be strongly influenced by changing the thickness of Ho layer.
Optimizing the structural design of a nanocomposite catalyst layer for PEM fuel cells for improving mass-specific power density
Authors: Hou Junbo , Yang Min , Ke Changchun , Wei Guanghua , Zhang Junliang
Published: May 2020

Ultrathin catalyst layer structures with ultralow Pt loading in the total design of PEM fuel cells are comprehensively reviewed.
A co-crystallization induced surface modification strategy with cyanuric acid modulates the bandgap emission of carbon dots
Authors: Zhou Zhengjie , Ushakova Elena V. , Liu Enshan , Bao Xin , Li Di , Zhou Ding , Tan Zhanao , Qu Songnan , Rogach Andrey L.
Published: May 2020

A co-crystallization strategy with cyanuric acid to modulate the bandgap emissions of CDs was realized to produce highly emissive solid composite CD-based materials.
Boosting the energy density of supercapacitors by encapsulating a multi-shelled zinc–cobalt-selenide hollow nanosphere cathode and a yolk–double shell cobalt–iron-selenide hollow nanosphere anode in a graphene network
Authors: Mohammadi Zardkhoshoui Akbar , Hosseiny Davarani Saied Saeed
Published: May 2020

A facile strategy is developed to construct graphene-encapsulated multi-shelled zinc–cobalt-selenide hollow nanospheres and graphene-encapsulated yolk–double shell cobalt–iron-selenide hollow nanospheres for asymmetric supercapacitors.
Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction
Authors: Strizhak Alexander V. , Babii Oleg , Afonin Sergii , Bakanovich Iuliia , Pantelejevs Teodors , Xu Wenshu , Fowler Elaine , Eapen Rohan , Sharma Krishna , Platonov Maxim O. , Hurmach Vasyl V. , Itzhaki Laura , Hyvönen Marko , Ulrich Anne S. , Spring David R. , Komarov Igor V.
Published: May 2020

Photoisomerization of diarylethene-modified peptides changes the thermodynamics of their binding to MDM2: the “closed” photoisomers bind largely due to a high negative enthalpy, whereas the “open” forms bind better due to a more favourable entropy.
Stereoselective cationic polymerization of vinyl ethers by easily and finely tunable titanium complexes prepared from tartrate-derived diols: isospecific polymerization and recognition of chiral side chains
Authors: Watanabe Hironobu , Yamamoto Takuya , Kanazawa Arihiro , Aoshima Sadahito
Published: May 2020

Isotactic poly(vinyl ether)s were generated by titanium TADDOLates, which can be prepared from naturally abundant tartaric acid in a facile and economical manner with well-defined structures.
Design of fluorinated hyperbranched polyether copolymers for 19F MRI nanotheranostics
Authors: Celentano Wanda , Neri Giulia , Distante Francesco , Li Min , Messa Piergiorgio , Chirizzi Cristina , Chaabane Linda , De Campo Floryan , Metrangolo Pierangelo , Baldelli Bombelli Francesca , Cellesi Francesco
Published: May 2020

19F MRI contrast agents and drug nanocarriers based on fluorinated hyperbranched polyether copolymers.
Self-assembly of flavin mononucleotide and a cationic polythiophene in aqueous media: spectroscopic studies and sensing applications
Authors: Zhang Li , Li Shuanghong , Sun Yanan , Xiao Keren , Song Gang , Lu Pingan , Yin Shutao , Huang Kunlun , Yao Zhiyi
Published: May 2020

Self-assembly of flavin mononucleotide and a cationic polythiophene in 100% aqueous media with colorimetric and fluorescence dual responses.
Anthracene–styrene-substituted m-carborane derivatives: insights into the electronic and structural effects of substituents on photoluminescence
Authors: Chaari Mahdi , Kelemen Zsolt , Choquesillo-Lazarte Duane , Teixidor Francesc , Viñas Clara , Núñez Rosario
Published: May 2020

Efficient light emitters based on anthracene derivatives were developed. We prove that m-carborane is a perfect scaffold for coupling to anthracene giving rise to superb emitters in solution, while keeping the emission properties in aggregate state.
Structural studies of two capsaicinoids: dihydrocapsaicin and nonivamide. 13C and 15N MAS NMR supported by genetic algorithm and GIAO DFT calculations
Authors: Siudem Paweł , Bukowicki Jarosław , Wawer Iwona , Paradowska Katarzyna
Published: May 2020

The conformations of dihydrocapsaicin and nonivamide were studied by ssNMR spectroscopy supported by theoretical DFT/GIAO and genetic algorithm calculations.
Facile control of surfactant lamellar phase transition and adsorption behavior
Authors: Gonçalves Rui A. , Naidjonoka Polina , Nylander Tommy , Miguel Maria G. , Lindman Björn , Lam Yeng Ming
Published: May 2020

The presence of small water-soluble additives makes it possible to tune the surfactant gel-to-liquid crystalline (Lβ–Lα) phase transition temperature (Tm) for a bilayer-forming cationic surfactant system and its phase behavior on dilution.
Polymer-assisted synthesis and applications of hydroxyapatite (HAp) anchored nitrogen-doped 3D graphene foam-based nanostructured ceramic framework
Authors: Manoj Murugesan , Song Jinbo , Zhu Wenjian , Zhou Hu , Zhang Junhao , Meena Palaniappan , Yuan Aihua
Published: May 2020

Hydroxyapatite anchored nitrogen-doped three-dimensional graphene (HAp-N3DG) skeletal network (foam) based nanostructured ceramic framework (CF) was developed through a polymer-assisted solvothermal route.
Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents
Authors: Huang Lin , Huang Rong , Pang Fuhua , Li Anke , Huang Guobao , Zhou Xiaoqun , Li Qian , Li Fangyao , Ma Xianli
Published: May 2020

A series of novel dehydroabietic acid derivatives containing pyrimidine moieties were designed and synthesized. Some of them displayed more potent inhibitory activities compared with 5-FU.
Effects of temperature and humidity on the performance of a PECH polymer coated SAW sensor
Authors: Pan Yong , Zhang Lin , Cao Bingqing , Xue Xufeng , Liu Weiwei , Zhang Caihong , Wang Wen
Published: May 2020

The influences of environment, such as temperature, humidity and interfering gases, on the performance of a surface acoustic wave (SAW) sensor in the detection of 2-chloroethyl ethyl sulfide (CEES) were invested.
High-performance ferroelectric non-volatile memory based on La-doped BiFeO3 thin films
Authors: Dai Wanqiong , Li Yuanxiang , Jia Caihong , Kang Chaoyang , Li Mengxin , Zhang Weifeng
Published: May 2020

An ultrathin (6.2 nm) ferroelectric La0.1Bi0.9FeO3 (LBFO) film was epitaxially grown on a 0.7 wt% Nb-doped SrTiO3 (001) single-crystal substrate by carrying out pulsed laser deposition to form a Pt/La0.1Bi0.9FeO3/Nb-doped SrTiO3 heterostructure.
Studying key processes related to CO2 underground storage at the pore scale using high pressure micromodels
Authors: Morais Sandy , Cario Anaïs , Liu Na , Bernard Dominique , Lecoutre Carole , Garrabos Yves , Ranchou-Peyruse Anthony , Dupraz Sébastien , Azaroual Mohamed , Hartman Ryan L. , Marre Samuel
Published: May 2020

Micromodels experimentation for studying and understanding CO2 geological storage mechanisms at the pore scale.
Tungsten–zirconia-supported rhenium catalyst combined with a deoxydehydration catalyst for the one-pot synthesis of 1,4-butanediol from 1,4-anhydroerythritol
Authors: Wang Tianmiao , Nakagawa Yoshinao , Tamura Masazumi , Okumura Kazu , Tomishige Keiichi
Published: May 2020

Biomass-derived 1,4-anhydroerythritol is reduced to 1,4-butanediol over a reusable mixture of heterogeneous catalysts, ReOx–Au/CeO2 and ReOx/WO3–ZrO2.
A polycyclic aromatic hydrocarbon diradical with pH-responsive magnetic properties
Authors: Fu Xiangyu , Han Han , Zhang Di , Yu Han , He Qilin , Zhao Dahui
Published: May 2020

A novel polycyclic aromatic hydrocarbon molecule exhibiting manifold zwitterionic, diradical and quinoidal characteristics is designed and synthesized. Via reversible protonation, its pH-responsive magnetic properties are demonstrated.
Recent advances in N-heterocyclic carbene-based radical catalysis
Authors: Ishii Takuya , Nagao Kazunori , Ohmiya Hirohisa
Published: May 2020

This minireview examines the history and state-of-the-art of the N-heterocyclic carbene-based radical catalysis.
Synthetic investigation of competing magnetic interactions in 2D metal–chloranilate radical frameworks
Authors: Collins Kelsey A. , Saballos Richard J. , Fataftah Majed S. , Puggioni Danilo , Rondinelli James M. , Freedman Danna E.
Published: May 2020

2D metal–organic frameworks provide insight into kagomé spin physics.
Differentiating Aβ40 and Aβ42 in amyloid plaques with a small molecule fluorescence probe
Authors: Yang Jing , Zhu Biyue , Yin Wei , Han Zhihao , Zheng Chao , Wang Peng , Ran Chongzhao
Published: May 2020

A small molecule fluorescence probe ICTAD-1 was rationally designed for differentiating Aβ40 and Aβ42 in solutions and in Aβ plaques.
Cobalt(ii) ions and cobalt nanoparticle embedded porous organic polymers: an efficient electrocatalyst for water-splitting reactions
Authors: Gopi Sivalingam , Giribabu Krishnan , Kathiresan Murugavel , Yun Kyusik
Published: May 2020

Development of a highly efficient electrocatalyst for the water-splitting reaction is essential and in this regard, the use of earth-abundant metal catalysts offers several advantages such as improved performance, cost-efficiency, etc.
Surface enrichment of ions leads to the stability of bulk nanobubbles
Authors: Zhang Hongguang , Guo Zhenjiang , Zhang Xianren
Published: May 2020

Charge enrichment at nanobubble interfaces generates an electric field energy that leads to thermodynamic metastability of nanobubbles.
A theoretical phase diagram for an active nematic on a spherical surface
Authors: Brown Aidan T.
Published: May 2020

The trajectories of +1/2 defects on an active nematic shell were calculated numerically. As shown, 4 distinct trajectory types were identified and a trajectory phase diagram was constructed.
Tailored nanoscale interface in a hierarchical carbon nanotube supported MoS2@MoO2-C electrode toward high performance sodium ion storage
Authors: Ma Chunrong , Xu Zhixin , Jiang Jiali , Ma ZiFeng , Olsen Tristan , Xiong Hui , Wang Shuguang , Yuan Xian-Zheng
Published: May 2020

A MoS2/MoO2 heterointerface is created, with MoO2 nanocrystals anchored on MoS2 nanosheets, assisted by an N-doped carbon protecting layer, on CNTs. The electrode has a high specific capacity of ∼700 mA h g−1 at 0.2 A g−1, excellent cycling stability and rate capability.
Mixed proton–electron–oxide ion triple conducting manganite as an efficient cobalt-free cathode for protonic ceramic fuel cells
Authors: Wang Ning , Hinokuma Satoshi , Ina Toshiaki , Zhu Chunyu , Habazaki Hiroki , Aoki Yoshitaka
Published: May 2020

Cubic La0.7Sr0.3Mn1−xNiyO3−δ undergoes the hydration reaction with the charge disproportionation between Mn and O atoms, and thus, can reduce the interfacial polarization of protonic solid oxide cells due to the H+/O2−/e− triple conductivity.
Controlled release of small molecules and proteins from DNA-surfactant stabilized metal organic frameworks
Authors: Tolentino Mark Q. , Hartmann Alyssa K. , Loe David T. , Rouge Jessica L.
Published: May 2020

Enhanced stability and dual-responsive behavior were imparted to ZIF-8 MOFs via encapsulation in DNA-surfactant conjugates and a peptide crosslinked micelle.
Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism
Authors: Mangal Joslyn L. , Inamdar Sahil , Yang Yi , Dutta Subhadeep , Wankhede Mamta , Shi Xiaojian , Gu Haiwei , Green Matthew , Rege Kaushal , Curtis Marion , Acharya Abhinav P.
Published: May 2020

Metabolites control immune cell functions, and delivery of these metabolites in a sustained manner modulate the function of the immune cells.
Compositionally driven relaxor to ferroelectric crossover in (1 − x)Na0.5Bi0.5TiO3–xBiFeO3 (0 ≤ x ≤ 0.60)
Authors: Ren Pengrong , Wang Yike , Waidha A. I. , Clemens O. , K. V. Lalitha
Published: May 2020

The electromechanical properties of (1 − x)NBT–xBFO indicate a criticality at x = 0.3, beyond which the material transforms from a relaxor to ferroelectric. This correlates well to the changes in the rhombohedral distortion and domain structure.
A recyclable and photocontrollable resistive memory device based on polycoumarinsiloxanes
Authors: Chen Zhen , Liu Yuchao , Li Huihui , Sun Xiaoli , Yan Shouke , Ren Zhongjie
Published: May 2020

A photocontrollable and recyclable resistive WORM device based on polycoumarinsiloxanes is demonstrated.
Control of molecular packing toward a lateral microresonator for microlaser array
Authors: Jin Xue , Huang Han , Wang Xuedong , Liao Qing , Hu Wenping , Fu Hongbing
Published: May 2020

We demonstrated a facile method to prepare uniform nanolaser arrays based on a transverse lateral Fabry–Pérot (FP) microresonator built within single-crystalline organic microribbons of 1,4-bis((E)-2,4-dimethylstyryl)-2,5-dimethylbenzene (6M-DSB).
“Heavy-atom effects” in the parent [1]benzochalcogenopheno[3,2-b][1]benzochalcogenophene system
Authors: Wang Chengyuan , Abbas Mamatimin , Wantz Guillaume , Kawabata Kohsuke , Takimiya Kazuo
Published: May 2020

Effects of the chalcogen atoms in [1]benzochalcogenopheno[3,2-b][1]benzochalcogenophenes (BXBXs), the key π-conjugated core structures in the development of superior organic semiconductors, are investigated.
Solution-precipitation synthesis of perovskite polyhedron and its lasing applications
Authors: Xu Tao , Yang Xianfeng , Xing Jun , Cheng Jinsong , Yu Huakang , Yang Zhongmin
Published: May 2020

CH3NH3PbBr3 micro-polyhedrons were synthesized by using a two-step solution precipitation method and demonstrated single mode lasing ability.
Photo-electrochemical properties of CuO–TiO2 heterojunctions for glucose sensing
Authors: Tobaldi David Maria , Espro Claudia , Leonardi Salvatore Gianluca , Lajaunie Luc , Seabra Maria Paula , Calvino José Juan , Marini Silvia , Labrincha João António , Neri Giovanni
Published: May 2020

Glucose sensing is promoted by halogen lamp photo-activation in CuO–TiO2 heterojunctions.
Whole exome sequencing identified a new compound heterozygous PRKN mutation in a Chinese family with early-onset Parkinson’s disease
Authors: Li Tianbai , Kou Daqing , Cui Yanhua , Le Weidong
Published: May 2020

Early-onset Parkinson’s disease (EOPD) is usually caused by genetic variants and patients with EOPD develop symptoms before the age of 50, accounting for 5% Parkinson’s disease (PD). Here we present a Chinese Han pedigree with clinical features of EOPD. To determine the diagnosis and pathogenic mutations of this pedigree, whole exome sequencing, Sanger sequencing and real-time quantitative PCR were performed to detect all the four family members. Our results showed that a new form of compound heterozygous mutation in the PRKN gene, consisting of heterozygous point mutation c.850G > C (p.G284R) along with exon 4 deletion, is the causative genetic factor for EOPD in this pedigree. These discoveries may have implications for genetic counseling, clinical management and developing PRKN target gene therapy strategy.