bluuebunny/crossref_metadata_2025 huggingface dataset:
ПУБЛІЧНЕ УПРАВЛІННЯ ТЕРИТОРІАЛЬНИМ РОЗВИТКОМ ГРОМАД В УМОВАХ ЦИФРОВОГО СУСПІЛЬСТВА У СОЦІАЛЬНІЙ СФЕРІ
Authors: Євченко Дмитро Миколайович , Хожило Ірина Іванівна
Published: March 2023

У статті здійснено характеристику особливостей здійснення моделі публічного управління територіальним розвитком громад в умовах цифрового суспільства у соціальній сфері. Підкреслено, що успішність процесів цифровізації безпосередньо впливає на встановлення рівня ефективності здійснення реформи децентралізації публічної влади в Україні, що вимагається як в цілому, так і на рівні окремих сфер суспільного життя, зокрема, у сферах освіти, охорони здоров’я, соціального захисту, енергетики, громадського транспорту, питаннях громадської безпеки тощо. Визначено, що принципи здійснення публічного управління територіальної громади в умовах цифровізації мають ґрунтуватися на принципах концепції «good governance», які розуміються як: 1) активізація участі громади в ухваленні важливих рішень; 2) відкритість і прозорість регіональних суб’єктів владних повноважень, що передбачає необхідність забезпечення публічного доступу до інформації; 3) підзвітність та субординаційних зв’язки всіх учасники процесу публічного управління; 4) досягнення балансу приватного та публічного інтересів; 5) формування дохідної частини місцевих бюджетів на засадах бездотаційності. Зроблено висновок, що цифровізація соціальної сфери розвитку територіальної громади дозволяє подолати численні обмеження її становлення, зокрема, в частині реалізації права особи на здобуття професії, додаткової освіти, задоволення духовно-культурних потреб та інтересів тощо. Обґрунтовано, що цифровізація публічного управління територіальної громади має ґрунтуватися на розробленій моделі розробки та прийняття управлінських рішень та адміністративних актів, узагальненні значного обсягу інформації, організації ведення загальнонаціональних та регіональних реєстрів, що дозволяє врегулювати ряд взаємопов’язаних бізнес-завдань. Зроблено висновок, що з метою забезпечення ефективності здійснення публічного адміністрування територіальним розвитком громад в умовах цифровізації в соціальній сфері є необхідним: удосконалення нормативно-правового регулювання процесів цифровізації з метою створення умов для налагодження взаємодії громадського суспільства та органів муніципальної влади; створення умов для акумуляції та зберігання баз даних, необхідних для впровадження концепції «good governance», основою якої є прозорість, відкритість та доступність суб’єктів владних повноважень для споживачів публічних послуг та процедур.
ЗАБЕЗПЕЧЕННЯ ПРАВА НА ЗДОРОВЕ ПРИРОДНЄ СЕРЕДОВИЩЕ: ДОСВІД ВЕЛИКОБРИТАНІЇ
Authors: Волкова Юлія Анатоліївна
Published: March 2023

У статті досліджено досвід Великобританії щодо розробки та імплементації в національне законодавство права на здорове природнє середовище. Констатовано, що з юридичної точки зору визнання права на здорове природнє середовище має суттєві процесуальні наслідки. Беручи за орієнтир реалізацію права на здорове природнє середовище національними юрисдикціями, більшість держав прийняли законодавство, що визначає процесуальні та матеріальні елементи, які дозволяють досить ефективно реалізовувати це право. Вказано, що з одного боку, визнання права на здорове природнє середовище часто передбачає відстоювання процесуальних прав, таких як право на отримання інформації, на участь у прийнятті рішень з екологічних питань та на отримання доступу до правосуддя. Поряд з процесуальними правами право на здорове природнє середовище містить і матеріальну складову. За визначенням, право на здорове природнє середовище, незалежно від його точного формулювання, захищає елементи природного середовища, які забезпечують гідне життя. Воно передбачає збереження основних прав людини, таких як право на життя, чисту воду, їжу тощо. Зроблено висновок, що ООН поставила знаменну перевагу у визнанні права на природу шляхом визнання права на здорове природнє середовище. Безумовно це важливий юридичний чинник для відновлення природи заради неї самої. Уряду Великобританії доцільно визнати нову резолюцію та вживши заходів щодо внутрішньої імплементації. Ці кроки не просто визнають право на здорове природнє середовище, а встановлять ціль та створять передумови для його реалізації. Вони дадуть підстави позиціонувати Великобританію, як одну з прогресивних країн, які вжили заходів для того, щоб кожен міг реалізувати право на здорове природнє середовище.
РОЗВИТОК ПУБЛІЧНОГО УПРАВЛІННЯ З ПОЗИЦІЙ ІНСТИТУЦІОНАЛЬНОГО ПІДХОДУ
Authors: Липовська Наталія Анатоліївна , Пашкова Ганна Геннадіївна , Сахарова Катерина Олександрівна
Published: March 2023

У статті розглядаються інститути управління (інструментальні, нормативно-рольові і комунікативні) в контексті їх теоретичного дослідження, визначаються межі концепту «інститут», аналізується категорія «інститут публічного управління», визначається місце інституту державного управління в публічному управлінні, характеризуються стратегії управлінського впливу на інститути в контексті етапів інституціонального розвитку. Обгрунтовано, що безумовне підпорядкування і примус є неодмінними атрибутами інструментальних інститутів. Нормативно-рольовий інститут розглядається насамперед крізь призму результатів його функціонування в суспільстві. Визначено, що розвиток демократичних форм участі громадян в управлінні, становлення громадянського суспільства приводять до появи нового типу інститутів управління – комунікативних, функціонування яких пов’язане не тільки з усвідомленням необхідності інститутів, але і з можливістю постійного їхнього коректування в комунікативному діалозі. Комунікативний інститут – це керований інститут, тому його розвиток вимагає розширення навичок самоконтролю і децентралізації. Показано, що інститут – не тільки визначена стійка норма, правило, закон, але і саморозвиток цієї норми, правила, закону, а також діяльність по встановленню норми, правила і закону. Тут сполучаються статична, динамічна й управлінська характеристики інституту, його стійкість, здатність встановлюватися і здатність бути встановленим. Визначено істотні характеристики публічного управління, зокрема вплив суб’єкта управління на об’єкт із метою досягнення консенсусу; механізм внутрішньої саморегуляції суспільства, що є практичним проявом інституціональної природи управління; «державне управління», здійснюване інститутом державної влади, «місцеве самоврядування», яке здійснюється, відповідно, органами місцевого самоврядування і «самоврядування», здійснювані громадянським суспільством; «м’яке» управління, націлене на консолідацію, солідарність і співробітництво.
ФОРМУВАННЯ ПУБЛІЧНОУПРАВЛІНСЬКОГО МЕХАНІЗМУ ЗАБЕЗПЕЧЕННЯ ДЕРЖАВНОЇ БЕЗПЕКИ І ПРАВОПОРЯДКУ В УМОВАХ ДЕЦЕНТРАЛІЗАЦІЇ ДЕРЖАВНОЇ ВЛАДИ
Authors: Гавриленко Костянтин Миколайович
Published: March 2023

У статті проаналізовано формування публічноуправлінського механізму забезпечення державної безпеки і правопорядку в умовах децентралізації державної влади. Встановлено залежність формату забезпечення державної безпеки і правопорядку від перебігу сучасної реформи правоохоронних органів, особливостями правового режиму воєнного стану, посиленням впливу правоохоронних органів на реалізацію завдань функцій держави. Доведено, що проблема забезпечення державної безпеки і правопорядку набула особливої актуальності в умовах реформи децентралізації в Україні, що обумовлено зміною структури і функцій органів влади в системі державної безпеки. Наголошено, що в системі національної безпеки України важливим завданням діяльності органів публічної влади виступає реформування функцій, структури та повноважень суб’єктів управління з метою забезпечення захищеності держави, суспільства і громадян від зовнішніх та внутрішніх загроз. Встановлено, що у сучасних умовах реформи децентралізації особливого значення набуває Теоретико-методологічні засади державного управління у сфері державної безпеки та охорони громадського порядку як цілеспрямованого впливу держави щодо захисту державного суверенітету, конституційного ладу, територіальної цілісності, економічного, науково-технічного і оборонного потенціалу, законних інтересів держави та прав громадян. Доведено, що раціональна модель правової держави потребує чіткої визначеності інституту державної безпеки та правопорядку як об’єкту державного управління шляхом наукового закріплення структури, форми, методів та принципів. З цією метою у статті розкрито сутність формування концепту територіального управління правоохоронними органами на основі принципу респонсивності.
Kajian Komunitas Ikan Dalam Aplikasinya Bidang Ekologi Perairan
Authors: Silaen Sri Natalia
Published: March 2023

Indonesia is one of the developing countries in Asia. As a developing country, Indonesia always strives to advance development in all fields including agriculture in a broad sense. The aim of economic development is to increase and expand employment opportunities, increase income, reduce poverty and simultaneously improve people's welfare. The purpose of this research was to determine the effect of partial land area on fish production, to determine the effect of the number of seeds partially stocked on fish production, to determine the effect of land area and the number of seeds stocked together on fish production. Coastal areas have a variety of potentials, including primary food sources containing protein (especially animal protein derived from fish, shrimp and the like), oil, gas and other mineral wealth that has potential in the fields of mining, tourism, settlements and industrial development.
LEVANTAMENTO NÃO CIRÚRGICO DO SISTEMA MÚSCULO-APONEURÓTICO SUPERFICIAL
Authors: De Oliveira Terezinha Rezende Carvalho , Pacheco Roberto Fernandes , Cardoso Álida Lúcia
Published: March 2023

Objetivo:  realizar e apresentar a técnica de lifting facial não cirúrgico por meio da elevação do sistema músculo-aponeurótico superficial (SMAS) ancorado no músculo temporal, desenvolvida por Sedev. Métodos: os artigos foram selecionados do ano 1976 a 2022, obtidos nas bases científicas Lilacs, Pubmed e Scielo. A suspenção do SMAS, devolve o posicionamento anatômico das estruturas da face e músculo platisma. Para isso, foram elaborados instrumentos específicos de pontas arredondadas e tamanhos ajustados para descolar os tecidos e abrir caminho de passagem do fio de nylon trançado, não reabsorvível para, posteriormente ser ancorado na região do músculo temporal. Conclusão: A técnica relatada, mostru-se segura e eficaz a ser realizado em consultório odontológico. Proporciona o rejuvenescimento rápido, com curto tempo de recuperação, podendo ser associado aos injetáveis.
LASERTERAPIA NO TRATAMENTO DE ACNE
Authors: Rodrigues Fabrizio Manoel , Khachikian Luciana Camargo , Bello Liciane Toledo
Published: March 2023

Objetivo: Apresentar revisão bibliográfica sobre os tratamentos com a utilização de laserterapia nos tratamentos de acne vulgar. Revisão Bibliográfica: A utilização dos comprimentos de onda é efetivo no tratamento da acne vulgar, e podem ainda, ser utilizados associados a fotossensiblizadores, o que dá origem a reação de formação de oxigênio singleto (ROS) e tem potencial bactericida importante no combate à acne. Dependendo do comprimento de onda, a ROS pode ser iniciada através das porfirinas endógenas bacterianas, ou seja, um fotossensibilizador endógeno. Conclusão: Apesar de sua eficácia, a laserterapia necessita ainda de estudos complementares e de forma randomizados, a fim de padronizar sua prescrição no tratamento de acne vulgar.
Canakinumab for Adult-Onset Still Disease
Authors: Tran Khai , Mierzwinski-Urban Monika
Published: March 2023

This review identified limited evidence from 2 systematic reviews about the clinical effectiveness and safety of canakinumab for patients with adult-onset Still disease (AOSD). Most studies in the systematic reviews on AOSD did not have a control group; therefore, the findings related to the effectiveness and safety of canakinumab in this population are uncertain.

For adults with AOSD, treatment with canakinumab may be associated with a complete or partial response to treatment, corticosteroid-sparing effect, and a decrease or normalization of key laboratory parameters, such as leukocyte count, erythrocyte sedimentation rate, and serum levels of ferritin and C-reactive protein, compared with baseline.

In adults with AOSD, limited evidence suggested there was no statistically significant difference between canakinumab and placebo in articular manifestations.

Adverse events associated with canakinumab treatment included infections, leukopenia, musculoskeletal and connective tissue disorders, skin disorders, thoracic and mediastinal disorders, gastrointestinal disorders, and site injection reactions. Severe adverse events included macrophage activation syndrome, hepatocytotoxicity, and serious infections that led to discontinuation of treatment.

No studies were found comparing canakinumab and alternative pharmacologic treatments for AOSD.

No studies were found on the cost-effectiveness of canakinumab for the treatment of AOSD.

No evidence-based guidelines were found on the use of canakinumab for the treatment of ASOD.
TROPHIC DISORDERS IN VARICOSE DISEASE – EPIDEMIOLOGICAL CHARACTERISTICS
Authors:   Belarusian State Medical University, Yu. V. Kuzmin
Published: March 2023

Trophic disorders in chronic venous insufficiency of the lower extremities is currently an important problem. In countries with developed economies, in chronic venous insufficiency, 15–18% of the population has decompensated forms with severe trophic skin disorders. We studied 10326 case histories and statistical charts of patients with varicose veins of the lower extremities, of which 2275 patients had chronic venous insufficiency C4-C6 (from 2010 to 2019). The paper shows the structure of the incidence of chronic venous insufficiency C4-C6, the influence of the age of men and women on the development of trophic disorders in varicose saphenous veins of the lower extremities. Causes of chronic venous insufficiency C4-C6 are shown.
SUBJECTIVE ASSESSMENT OF MEDICAL MASK OPERATING CONDITIONS BY MEDICAL PROFESSIONALS DURING THE COVID-19 PANDEMIC
Authors:   Scientific and Practical Center for Hygiene, E. A. Semushyna , S. N. Tolkach ,   Scientific and Practical Center for Hygiene, O. K. Siniakova ,   Scientific and Practical Center for Hygiene, E. S. Shcherbinskaya ,   Scientific and Practical Center for Hygiene
Published: March 2023

Specialists of the republican unitary enterprise "Scientific and Practical Centre of Hygiene" have developed a questionnaire that allows medical workers of healthcare organizations of outpatient and inpatient profile to assess the body’s state during the operation of medical masks in a favorable and unfavorable epidemic situation. 270 medical workers were interviewed, of which physicians – 24%, middle medical staff – 60%, junior medical staff – 16%. The survey showed that the operation time of medical devices for respiratory tract protection in an unfavorable epidemic situation exceeds than in a favorable epidemic situation both in outpatient and polyclinic healthcare organizations and in inpatient healthcare organizations. Increasing operation time of medical devices for respiratory tract protection during one work shift is accompanied by increasing number of symptoms of the fatigue process and their severity. In this case, the nature of these symptoms is different for medical workers of various health care organizations.
THE INCIDENCE AND PREVALENCE OF SYSTEMIC LUPUS ERYTHEMATOSUS AMONG THE ADULT URBAN POPULATION IN BELARUSIAN POPULATION
Authors:   Belarusian State Medical University, V. E. Yagur , K. A. Chizh ,   Belarusian State Medical University, N. Y. Dostanko ,   Belarusian State Medical University
Published: March 2023

The presented paper is devoted to the epidemiological characteristics of systemic lupus erythematosus as one of the most common systemic connective tissue diseases. Data on age, sex, racial and geographical differences of this pathology in different countries are given. Much attention is paid to a detailed review of data on primary morbidity (incidence) and general morbidity (prevalence). The results of authors’ own study of prevalence and incidence of systemic lupus erythematosus in the urban population of the Republic of Belarus are analyzed. An example of using the results obtained to calculate the need in specialized inpatient medical care for patients with systemic lupus erythematosus within its rational planning is proposed.
CORRECTION OF CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES MELLITUS IN A TIME OF COVID-19 PANDEMIC
Authors:   Belarusian State Medical University, A. A. Bova , Y. M. Gromova ,   Belarusian State Medical University, S. M. Metelsky ,   Belarusian State Medical University
Published: March 2023

Arterial hypertension and diabetes mellitus – established large risk factors for cardiovascular diseases associated with atherosclerosis – are among the most common comorbidities in patients with coronavirus infection. Each of the pathologies, and especially their combination increases the cardiovascular risk, and in case of SARS-Cov-2 infection, the risk of severe course of infection and mortality. The article discusses the mechanisms of mutual burden of coronavirus infection, arterial hypertension and diabetes mellitus, provides a new concept of activating the immune system in hypertension, considers modern approaches to antihypertensive therapy in patients with diabetes mellitus.
PROBLEMS OF DIAGNOSTICS AND TREATMENT OF FOURNIER'S GANGRENE
Authors:   Belarusian State Medical University, A. V. Danilchyk , Yu. V. Kuzmin ,   Belarusian State Medical University, A. S. Zhidkov ,   Belarusian State Medical University
Published: March 2023

Fournier's gangrene is a rare disease with a severe course and high mortality, the prognosis of which depends on timely diagnosis and timing of surgical intervention. Nonspecific clinical manifestations and the rapid development of the inflammatory process create certain difficulties for surgeons in making the correct diagnosis and treating such patients. This review presents the issues of diagnosis and treatment of Fournier's gangrene at the present stage of development of medicine.
Que contribuições virão de Amazônia brasileira para o urbanismo do século XXI?
Authors: Cardoso Ana Claudia
Published: March 2023

Este texto aborda a complexidade do município amazônico como ilustração para reflexões sobre a necessidade do urbanismo do Sul-Global incorporar discussões socioambientais. Parte-se das teses sobre estruturação do espaço intraurbano e sobre corredores verdes e azuis com o suporte de revisão de literatura, mapas históricos, pesquisas de campo, dados disponíveis em bases oficiais e uso de geotecnologias. No percurso, o clássico espaço intraurbano foi ampliado, e a partir de uma perspectiva decolonial, os territórios de povos da floresta foram reconhecidos como parte de uma variante de trama verde e azul. Conclui-se que a um urbano estendido corresponde um periurbano estendido, invisiblizado e sob forte pressão para seu desaparecimento, mas que é portador de soluções para crises socioambientais e conflitos recentes estabelecidos entre a cidade histórica e os ciclos e processos da natureza.
várzea à Avenida Pacaembu
Authors: Siqueira Renata
Published: March 2023

A demora e a descontinuidade na execução caracterizaram diversas obras do Plano de Avenidas, em São Paulo. Entre essas, o prolongamento da Avenida Pacaembu, partindo da rua das Palmeiras e estendendo o sistema viário até o rio Tietê. Idealizado em conjunto nos anos 1920 e consolidado no plano de 1930, esse projeto foi implantado esparsamente de 1938 até o fim dos anos 1960. Esta comunicação analisa a viabilização da primeira etapa, dos primeiros debates, em 1923, até sua inauguração, em 1942, quando a avenida alcançou a ferrovia, junto à estação da Barra Funda. No período anterior à construção, identificamos estratégias que garantiram a realização do empreendimento, incluindo a negligência em atender às demandas da população local. Consultando documentos da Câmara Municipal e da imprensa, cotejamos reivindicações populares por melhorias urbanas com o debate público do projeto, contextualizado no fortalecimento da defesa do plano como instrumento orientador do crescimento urbano. Nosso estudo de caso sugere que, ao invés de ineficiente, a administração foi ágil e habilidosa, negociando precoce e vantajosamente os terrenos destinados ao atendimento das “necessidades futuras” do município, bem que à custa das condições de vida dos habitantes da várzea.
crise da cidade e a subversão LGBT+ no carnaval de rua de Belo Horizonte
Authors: Rodrigues Chaves Nogueira Carolina , Garcia Gonçalves Raquel
Published: March 2023

O modo de produção capitalista que configura a cidade contemporânea conforma não apenas as políticas públicas, mas também as formas de vivência do espaço urbano, a partir da lógica da produtividade. Desdobram-se dois pontos, nesse contexto, importantes na perpetuação da crise da cidade, conceituada a partir de Lefebvre: a segregação de espaços e pessoas, e a relegação dos usos ligados ao ócio e ao prazer a segundo plano. O artigo discute, assim, a festa de Carnaval de Rua de Belo Horizonte/MG enquanto possível elemento transformador nas formas de uso e apropriação dos espaços públicos urbanos pela comunidade LGBT+, tomando-se como base as relações de poder relacionadas à cultura heteronormativa como impositora de padrões normativos, refletidos nas relações sociais e na cidade.
Grande Pirambu: o histórico de luta e suas consequências nos projetos para a via litorânea
Authors: Guerra Diógenes Marina
Published: March 2023

Partindo de uma perspectiva mais popular de contar a história, este trabalho tem o objetivo de retratar o histórico de luta por moradia e por permanência da comunidade do Grande Pirambu — no litoral oeste de Fortaleza — e como tal fato impactou significativamente e positivamente, até certo ponto, a implantação de dois grandes projetos de reestruturação da orla da região. Tais projetos influíram diretamente nas vidas dos moradores da comunidade. O primeiro, denominado Projeto Costa Oeste, visava a criação de uma via litorânea turística e de fluxo rápido. Posteriormente, após diálogos com a comunidade, este foi reelaborado e renomeado Projeto Vila do Mar, o qual previa um caráter mais local para a via. Cada um dos projetos apresenta objetivos claros e delineados e a resistência do Grande Pirambu fez sua voz ser ouvida nesse processo. Esses contextos serão retratados e analisados aqui partindo de uma visão mais popular que normalmente é ignorada.
Rehabitar o Imaginar, Reimaginar o habitar
Authors: Rozestraten Artur
Published: March 2023

Imagens fotográficas de passagens comuns (pan) a todos (demos), semeadas no Instagram, entre fevereiro de 2020 e janeiro de 2021, no Brasil.
conceito de integridade na conservação da arquitetura moderna
Authors: Barreto Lira Flaviana , Peixoto Allana , Luna de Melo Carlos Eduardo
Published: March 2023

A conservação do patrimônio arquitetônico envolve um processo de análise do bem no decorrer do tempo e tem como objetivo a manutenção do seu valor patrimonial. Os conceitos contemporâneos de significância cultural, autenticidade e integridade têm atuado como elementos balizadores das ações de conservação sobre o patrimônio. Dentro desse contexto, percebe-se que algumas obras da arquitetura moderna têm apresentado problemas que impactam diretamente a significância, a integridade, a autenticidade e, consequentemente, a manutenção das suas características de valor patrimonial. Observa-se, muitas vezes, a existência de conflitos entre as condições de degradação do bem e a manutenção do seu valor patrimonial, indicando dificuldades quanto à proposição de ações conservativas que possam gerar um menor impacto possível sobre tais valores. Apesar da importância do conceito de integridade no processo de conservação do patrimônio, ainda não há um consenso claro quanto ao sentido exato de sua aplicação ou ao estabelecimento de parâmetros específicos que possam guiar a sua avaliação na prática. O objetivo do presente trabalho é apresentar a importância do conceito de integridade dentro do contexto das ações de conservação e intervenção sobre os edifícios da arquitetura moderna e os principais desafios inerentes à sua aplicação prática no processo de conservação. Conclui-se que a integridade deve ser operacionalizada como ponto central do processo de conservação do patrimônio moderno, podendo apontar a necessidade de realização de intervenções e ações de manutenção em momento anterior à necessidade realização de intervenções de maior impacto, onde já se observa um avançado processo de degradação sobre o bem.
Lina e o Leão: geopolítica de uma homenagem tardia.
Authors: Anelli Renato Luiz Sobral
Published: March 2023

Este artigo procura identificar os sentidos da homenagem Leão de Ouro in memoriam (Bienal de Veneza 2021), recebida por Lina Bo Bardi três décadas após sua morte. Para isso, propõe-se a resgatar ideias e posicionamentos políticos expressos pela arquiteta ao longo de sua vida, que possam nos ajudar a refletir sobre sua atualidade, assim como identificar os riscos de fazê-lo sem mediações. Apresenta inicialmente seu mergulho intelectual no pensamento brasileiro, onde cria as ferramentas que orientaram sua busca pela construção de uma arquitetura / design que fosse moderno e popular. Aponta o fracasso do seu esforço de retornar à Europa os achados dessa busca e a sua filiação geopolítica às lutas anticoloniais e terceiro mundistas, através da qual procurou dar sentido político à sua produção. Identifica, na sua última fase iniciada em 1976, o equilíbrio entre intenção política e forma arquitetônica. Conclui avaliando a fortuna crítica internacional de sua obra após sua morte, a qual contextualiza os limites da atual homenagem.
Restauração Arquitetônica Enciclopedia Universale dell'Arte, vol. XI, 1963
Authors: Bonelli Renato , Andrade Júnior (trad.) Nivaldo , Graco Cafezeiro (trad.) Yan
Published: March 2023

O arquiteto Renato Bonelli (1911-2004) foi um dos principais responsáveis pela formulação e difusão da teoria do restauro crítico, desenvolvida na Itália no segundo pós-guerra. Ao longo de mais de seis décadas, Bonelli contribuiu de forma decisiva para as áreas da história da arquitetura – e, em especial, do método historiógrafico – e da teoria da restauração, como professor e como pesquisador, em uma trajetória profissional fortemente influenciada pela estética idealista. Especificamente no campo da restauração arquitetônica e urbanística, as contribuições de Bonelli são inúmeras, caracterizando a intervenção no patrimônio como uma ação cultural. Desta maneira, a tradução para o português, pela primeira vez, do seu texto mais conhecido, o verbete Il restauro architettonico, publicado na Enciclopedia Universale dell’Arte em 1963, pode contribuir para a difusão da teoria do restauro crítico na arquitetura e no urbanismo e, mais especificamente, do seu pensamento.
Urbanismos em estado selvagem: Por uma descolonização permanente do pensamento
Authors: Lopez de Ameilda Junior Dilton
Published: March 2023

A publicação de “Pensamentos selvagens”, o segundo volume de “Montagem de uma outra herança” de Paola Berenstein Jacques, na iminência de celebrarmos os duzentos anos de independência do Brasil concomitante aos cem anos da realização da Semana de Arte de 22, parece-nos ser destes gestos intelectuais nada fortuitos e de extrema coragem, assertividade, fôlego e rigor acadêmicos.
The efficacy of antibiotic-impregnated calcium sulfate (AICS) in the treatment of infected non-union and fracture-related infection: a systematic review
Authors: Jacob Connor C. , Daw Jad H. , Santiago-Torres Juan
Published: March 2023

Abstract. Background: the treatment of infected non-union to allow for bony healing
following orthopedic surgery remains a challenge. Antibiotic-impregnated
calcium sulfate (AICS) is an effective vehicle for antibiotic delivery, but
its efficacy in treating infected non-union in the setting of trauma and
fracture remains unclear. Methods: this systematic review analyses nine
studies from 2002 to 2022 that investigated AICS as a local antibiotic
delivery system for cases of fracture-related infection and infected non-union.
Results: in total, 214 patients who received AICS were included in this
review. Of these patients, there were 154 cases of infected non-union or
fracture-related infection. Across all studies analyzed, patients treated
concurrently with AICS and systemic antibiotics experienced a 92.9 %
rate of bony union and a 95.1 % rate of infection eradication. In
addition, 100 % of the 13 patients who were treated with AICS alone
experienced eradication of infection and successful bony union. Conclusion:
AICS is an effective method of antibiotic delivery with a low risk profile
that results in high rates of bony union and infection eradication even when
used in the absence of systemic antibiotics.
Rejuvenation of Pesticide Polluted Soil from the Isolated Microbial Flora of Agricultural Field
Authors: Sivakumar J.
Published: March 2023

The widespread use of pesticides leads to imbalances in the qualities of soil, water, and air environments. Pesticides can only be broken down more quickly by combining microbial consortia of native and naturally occurring bacteria isolated from certain polluted environments. To rejuvenate the pesticide polluted soil, the samples was collected and microbial flora were isolated from the soil samples. These floras were introduced into the three pesticides like Carbaryl, Monocrotophos and Malathion (CMM) for the biodegradation activity. Standard microbiological protocols were followed to isolate the microbial flora from the collected soil samples. The isolated microbial strains were confirmed with the isolation of genomic DNA. The biodegradation of pesticides such as Carbaryl, Monocrotophos and Malathion (CMM) were performed with the isolated strains. The bacterial strains such as Pseudomonas sp, Bacillus sp and Micrococcus sp; actinomycetes – Azatobacter; fungal species such as Aspergillus fumigatus, Gliocladium sp and Humicola sp were isolated from the agricultural field. Among these Bacillus sp showed highest biodegradation activity against the three pesticides. These investigations screened the best microorganism for several pesticides, including carbaryl, Monocrotophos, and Malathion (CMM), the best degradation methods, and the best degradation environment, providing a more practical reference for subsequent study.
Chaotic dynamics of the fractional order Schnakenberg model and its control
Authors: Md. Jasim  Uddin  , S. M.  Sohel Rana
Published: March 2023

The Schnakenberg model is thought to be the Caputo fractional derivative. In order to create caputo fractional differential equations for the Schnakenberg model, a discretization process is first used. The fixed points in the model are categorized topologically. Then, we show analytically that, under certain parametric conditions, a Neimark-Sacker (NS) bifurcation and a Flip-bifurcation are supported by a fractional order Schnakenberg model. Using central manifold and bifurcation theory, we demonstrate the presence and direction of NS and Flip bifurcations. The parameter values and the initial conditions have been found to have a profound impact on the dynamical behavior of the fractional order Schnakenberg model. Numerical simulations are shown to demonstrate chaotic behaviors like bifurcations, phase portraits, period 2, 4, 7, 8, 10, 16, 20 and 40 orbits, invariant closed cycles, and attractive chaotic sets in addition to validating analytical conclusions.  In order to support the system’s chaotic characteristics, we also compute the maximal Lyapunov exponents and fractal dimensions quantitatively. Finally, the chaotic trajectory of the system is stopped using the OGY approach, hybrid control method, and state feedback method.
Minimum Dominating Set for the Prism Graph Family
Authors: Jebisha Esther S  , J Veninstine Vivik
Published: March 2023

The dominating set of the graph G is a subset D of vertex set V, such that every vertex not in V-D is adjacent to at least one vertex in the vertex subset D. A dominating set D is a minimal dominating set if no proper subset of D is a dominating set. The number of elements in such set is called as domination number of graph and is denoted by $\gamma(G)$. In this work the domination numbers are obtained for family of prism graphs such as prism CL_n, antiprism Q_n and crossed prism R_n by identifying one of their minimum dominating set.
الأمن الفكري في تفسير ابن عثيمين
Authors:   أستاذ مساعد في التفسير وعلوم القرآن، قسم الدراسات الإسلامية، كلية التربية، جامعة حائل، المملكة العربية السعودية, الفطيمان حسن
Published: March 2023

تناول البحث موضوعاً من الموضوعات المهمة والذي كان بعنوان (الأمن الفكري في تفسير ابن عثيمين) دراسة موضوعية، حيث هدفت إلى استنباط مفهوم الأمن الفكري ومنهجيته عند ابن عثيمين من خلال تفسيره، واستخدم الباحث في دراسته المنهج الوصفي الاستنباطي. وجاءت الدراسة في ثلاثة مباحث، الأول: التعريف بتفسير ابن عثيمين، والأمن الفكري، والثاني: أسس الأمن الفكري في تفسير ابن عثيمين، أما الثالث: منهجية تفسير ابن عثيمين في تحقيق الأمن الفكري، وفي بيان قيمة الوسطية في تحقيق الأمن الفكري، وأهمية الدعوة بالحكمة والموعظة الحسنة في تحقيق الأمن الفكري، وبيان قيمة الحوار في تحقيق الأمن الفكري. وتوصلت الدراسة إلى مجموعة من النتائج منها: أسس الأمن الفكري في تفسير ابن عثيمين تمثلت في الأساس العقدي ويتمثل ذلك في الأسس الإيمانية المرتبطة بجانب إيمان الفرد وعقيدته، والأساس العلمي ويتمثل ذلك في الأسس العلمية المعتمدة على الفكر، من خلال الأخذ من المصادر الصحيحة، وأن يؤخذ من العلماء الربانيين في تحقيق الوسطية والاعتدال، والأساس الاجتماعي من خلال التواصي بالحق، والتعاون والتعايش مع غير المسلمين. ومنهج الأمن الفكري في تفسير ابن عثيمين اعتمد على بيان قيمة الوسطية في تحقيق الأمن الفكري، فمنهج الوسطية في تفسير ابن عثيمين يبني الفكر الصحيح ويُهيئ للسلام والوئام في المجتمع. وحث الباحث على الاهتمام بمنهج الشيخ العثيمين في تحقيق الأمن الفكري في المجتمع المسلم من خلال دراسة تفسيره، ووضع آليات وخطط تساعد على ترسيخ الأمن الفكري لدى الشباب من قبل المؤسسات التربوية المختلفة في المجتمع.
الطلح النجدي، توزيعه الجغرافي وخصائصه ومميزاته وفوائده البيئية والتنموية دراسة في جغرافية النبات باستخدام تقنيات الاستشعار عن بعد (Rs) ونظم المعلومات الجغرافية (Gis)
Authors:   طالب دكتوراه، جامعة القصيم، المملكة العربية السعودية, الشمري أحمد
Published: March 2023

هدفت هذه الدراسة إلى التعريف بالطلح النجدي من حيث الخصائص والمميزات والتوزيع الجغرافي والفوائد البيئية والاقتصادية والتنموية، لفت أنظار المهتمين والمجتمع المحلي للأهمية البيئية والاقتصادية للطلح النجدي ودورها في التنمية البيئية المستدامة، لفت الأنظار إلى الأخطار والتهديدات الطبيعية والبشرية التي يواجها الطلح النجدي. من أجل إيجاد الحلول لها وحمايتها، تحديد العوامل البيئية المناسبة لاستزراع الطلح النجدي. وإثبات أهميته في التشجير المدني والصحراوي، صنع خرائط رقمية للطلح النجدي بالاعتماد على تقنيات (GIS) و (RS) وبرامج حاسوبية تعتمد صور المرئيات الفضائية. من حيث توزيعها الجغرافي وحصر عددها. بما يفيد في الدراسات المستقبلية. وتمثلت منطقة الدراسة في الجزء الشمالي لهضبة نجد ضمن النطاق الصحراوي الجاف في وسط المملكة وتمتد في الجزء الشرقي من منطقة حائل على مسافة (130كم) شرق مدينة حائل ومسافة (150) غرب بريدة، وفلكياً تقع المنطقة المدروسة بين دائرتي عرض (27.2702 إلى 26.9998) شمال خط الاستواء، وخطي طول (42.7115 إلى 43.159) شرق خط جرينتش. حيث أظهرت الدراسة تأثير الطبوغرافية والجيولوجية وعناصر المناخ و المياه الجوفية على توزيع الطلح النجدي، وأظهرت من ناحية أخرى أثر النشاط الزراعي والعمراني كذلك تم التعرف على الفوائد البيئية والاقتصادية للطلح النجدي، وأظهرت الدراسة أهمية الطلح النجدي في عمليات التشجير المختلفة، وبينت الدراسة أهمية الطلح النجدي في التنمية البيئية المستدامة من خلال عدد من المميزات التي يمتلكها، وأظهرت نتائج الدراسة إمكانية استزراع الطلح النجدي و الاستفادة منه في العديد من المناشط البشرية التي تعتبر من أهم مجالات التنمية البيئية المستدامة، وقد استخدم في هذه الدراسة تقنيات حديثة كالمرئيات الفضائية، مع استخدام تقنيات بعض البرامج الحاسوبية، مما أعطى دقة عالية في العمل ورسم الخرائط.
The investigation of concomitant dermal and oral lichen planus in patients referred to Zahedan University centres
Authors: NOSRATZEHI Tahereh , PAYANDEH Abolfazl , NOSRATZEHI Atefeh
Published: March 2023

Lichen planus (LP) is a common chronic immunologic inflammatory epidermal and mucocutaneous disorder involving skin, oral mucosa and both sometimes, the main cause of which is still unknown. Due to the importance and its prevalence, this study was carried out in order to assess the association of oral and dermal lesions in patients referring to Dermatology Clinic and Department of Oral and Maxillofacial Diseases, Zahedan Dental School. In this descriptive study, a total of 99 patients with individual involvement of LP in skin or mucosa were selected among 6510 patients referring to Dermatology Clinic and Department of Oral and Maxillofacial Diseases, Zahedan Dental School. The selected cases were subjected to further and exact clinical examination along with interview, while in suspected lesions, the conducted histopatologic tests obtained by biopsy were used for the evaluation. A questionnaire was completed for each patient after taking history and physical examination, including history of systemic diseases, interacting medication, smoking habits, presence of oral and dermal lesions, the onset of mucosal and skin lesions and the treatment period, oral lesions signs and the patients complaint, involvement location, form, manner of distribution, oral lesion history as well as existence of amalgam restorations alongside the lesion chi-square used to assess differences for variables. The study revealed 38 percent association of oral and dermal lesions in the study population, while individual oral lesion was observed in 60.6 percent of patients and individual dermal lesions in 39.3 percent. The most reported symptom of oral lichen planus in the study population was the Oral ulcer, while the buccal mucosa was the most common site of involvement and erosive form was the high prevalent. The most reported symptom of dermal lichen planus in the study population was the Itching, while the Simultaneous hand and foot conflict was the most common site of involvement and Papular form was the high prevalent. High incidence of dermal and oral lichen planus association revealed throughout the study calls the attention for complete systemic examinations of the patients. As this study was carried out in the dermatology clinic, it seems that other studies in dental schools as well as throughout the public will be of necessity and importance to verify the results. According to this study, there was not a significant statistical relationship between LP and other variables.
The protective impact of glutamine on anti-tuberculosis drug-induced nephrotoxicity in Wistar rats
Authors: ADIKWU Elias , MBONU Martins , NNANNA Tobechi Brendan
Published: March 2023

This study assessed the protective effect of glutamine (GTN) against rifampicin/isoniazid/pyrazinamide/ethambutol (RIPE)-induced nephrotoxicity in rats. Thirty adult Wistar rats (200±20 g) of both sexes were grouped into 6 of 5 rats/group. The rats were treated daily for 30 days as follows: Group 1 (Vehicle control [normal saline 0.2mL]), group 2 (GTN 200 mg/kg), group 3 (RIPE 150, 75, 400 and 275 mg/kg in vehicle), group 4 (GTN 50 mg/kg +RIPE), group 5 (GTN 100 mg/kg +RIPE) and group 6 (GTN 200 mg/kg +RIPE). After treatment, blood samples were obtained and assessed for serum renal biomarkers. Kidneys were harvested, weighed and assessed for oxidative stress markers and histology. RIPE significantly (p<0.01) decreased body weight and significantly (p<0.01) increased kidney weight when compared to the control. Serum urea, creatinine, uric acid levels and kidney malondialdehyde levels were significantly (p<0.001) increased in RIPE-treated rats when compared to the control. Serum total protein, albumin, kidney glutathione, catalase, superoxide dismutase and glutathione peroxidase levels were significantly decreased (p<0.001) in RIPE-treated rats when compared to the control. RIPE caused tubular necrosis and collapsed glomeruli in the kidneys of rats. However, body and liver weights were significantly restored in GTN 100 mg/kg +RIPE and GTN 200 mg/kg +RIPE-treated rats at p<0.05 and p<0.01, respectively when compared to RIPE. Serum and kidney oxidative stress markers were restored in GTN 50 mg/kg +RIPE, GTN 100 mg/kg +RIPE and GTN 200 mg/kg +RIPE-treated rats at p<0.05, p<0.01 and p<0.001 respectively, when compared to RIPE. GTN restored kidney histology. GTN protects against RIPE-induced nephrotoxicity in a dose-related fashion.
The value of preoperative inflammatory markers in patients through total laryngectomy for advanced stage larynx carcinoma
Authors: ÇELEBİ Mehmet , MEHEL Dursun Mehmet , VAN Semih , CİHAN Seda Nur , ÖZDEMİR Doğukan , ÖZGÜR Abdülkadir
Published: March 2023

The aim of this study is to evaluate the difference between neutrophil, lymphocyte, platelet and RDW (red cell distribution width) counts and NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) between patients who underwent total laryngectomy for advanced stage laryngeal squamous cell carcinoma and healthy control group. The study group consisted of 37 patients (36 male, 1 female) who underwent total laryngectomy and bilateral neck dissection for advanced stage laryngeal squamous cell carcinoma between January 2017 and December 2019. As a control group, complete blood count records of 35 healthy individuals who were routinely examined in 2019 within the scope of occupational health and safety were compiled. Blood was collected preoperatively from the patient in the study group. The data obtained from the whole blood counts of the two groups were analyzed statistically by comparing neutrophil, lymphocyte, platelet, RDW, NLR and PLR values. The age difference between the study and control groups was not significant (p>0.05). Neutrophil, platelet and RDW counts were higher in the study group compared to the control group and this difference was statistically significant (p=0.001, p=0.035, p=0.001, respectively). Although the lymphocyte count was high in the study group, the difference was not significant (p=0.061). The difference between NLR and PLR between the two groups was high in the study group and this difference was statistically significant (p=0.001, p=0.007, respectively). Neutrophil, platelet, RDW, NLR, PLR values were significantly higher in patients with advanced stage laryngeal cancer than in the control group. NLR, PLR and RDW values, which can be obtained cheap, simple and rapidly at the diagnosis stage of laryngeal cancers, may be biomarkers in determining prognosis. For this, multicenter, prospective studies are needed.
Epidemiological and clinical characteristics, management, and outcomes of antenatal hydronephrosis: A single-centre experience of 229 cases
Authors: ÖNAL Mesut , ÖNAL Hülya Gözde
Published: March 2023

The advances in utilization of USG in antenatal routine follow-up resulted with increased diagnosis of antenatal hydronephrosis (ANH). This study was conducted to elaborate the epidemiological and clinical characteristics, management, outcomes, and possible risk factors of the ANH. A total of 229 cases diagnosed with ANH during the antenatal follow-up at the Obstetrics and Gynecology Department of OndokuzMayis University between 2004 and 2022 were included. The ANH was defined as an USG finding suggesting a hydronephrosis 7 mm. The epidemiological and clinical characteristics, risk factors, treatment and outcomes in the postnatal period were assessed retrospectively. About 75% of the cases were male, 8% were premature births, and the mean gestational week of diagnosis was 22±3 weeks. About 43.7% of mothers had urinary tract infections, and family history of a kidney disease was present in 24.5% of mothers’ and 20.5% of fathers’ family histories.38.7% of cases undergone surgery. At the end of 6-month follow-up, 37.3% had regressed and 38.7% of them had stable hydronephrosis, and 18.9% of them had normal findings in USG. Male gender, increased gestational urinary tract infections, and family histories of parents for a kidney disease were found as possible risk factors for development of ANH. Close follow-up and timely intervention including surgery provides favorable outcomes in these cases.
Stem cell applications in female infertility – A rewiev
Authors: ÖZDEMİR Ayşe Zehra , TAŞTAN Ayşe Şeyma
Published: March 2023

Infertility is a problem that affects approximately 15% of couples today. Although assisted reproduction techniques are widely used today, only 40-50% of couples who apply can have children with their own genetic structure. Especially in people with premature ovarian failure, the rate of conception does not exceed 5-10% with the treatments applied today. For this reason, many studies are carried out to obtain oocyte from stem cells with their proliferation and differentiation feature. In addition, regenerative cellular therapies that can replace assisted reproductive techniques and correct impaired fertility are also being investigated in both animal and human studies. In recent years, research has been carried out on stem cell-derived extracellular vesicles, which will eliminate immunological problems. In terms of safety and efficacy, clinical studies involving large populations are needed.
Emergencies in movement disorders
Authors: AYGÜN Dursun , POLAT Murat
Published: March 2023

Movement disorders can be defined as the abnormality of the speed and form of body movements. Although movement disorders often occur chronically, they can sometimes develop acutely or sub-acutely, and some can be fatal if not diagnosed and treated early. Here, emergencies in movement disorders are discussed under two main headings as emergencies related to hyperkinetic movement disorders and emergencies related to hypokinetic movement disorders. This review draws attention to the importance of that accurate diagnosis and early treatment can be life-saving in emergencies in movement disorders. It also provides recommendations for diagnosis and therapy.
CRISPR/Cas9 system in hematopoietic stem cells: Basic research and clinical applications
Authors: ALBAYRAK Esra
Published: March 2023

Clustered regularly interspaced short palindromic repeats (CRISPR) approach adapted from the prokaryotic adaptive immune system against to pathogen attack is so valuable and promising tool for treatment of human malignant and non-malignant hematological disease and disorders through genome editing in hematopoietic stem cells (HSCs). Moreover, CRISPR/Cas9 approach is not only useful for therapeutic purposes; it is considerably preferred for the generation of in vitro and in vivo animal disease models. CRISPR/Cas9 approach has been developed for highly efficient on-target cleavage, and low off-target effect via delivery systems and manipulation of CRISPR components including single guide RNA (sgRNA) and Cas enzymes. In this review, we focused on the CRISPR/Cas9 system applications on hematopoietic stem cells in basic research and clinical area with basic research and clinical perspectives.
The association between KRAS gene expression and breast tumors in a sample of Iraqi women
Authors: H. AL-HADDAD Roya , M. JASIM Hameed
Published: March 2023

In Iraq, breast cancer is considered one of the most widespread cancer types causing death in women due to changes in the genes that control cell growth and proliferation. KRAS gene plays a role in 30% of human cancers. This study aims to evaluate the expression of the KRAS gene and its role in women with breast tumours. A total of 120 women (60 women with breast tumours and 60 samples from apparently healthy women) were enrolled in this study to determine the expression of the KRAS gene. The RT-qPCR was used for this purpose. Fibroadenoma (FA) was the most common tumours, accounting for 53% of cases, followed by fibrocystic change (26%). Other benign tumours accounted for 20% of the cases; however, IDC is the most common type of invasive breast cancer, accounting for 70% of all breast cancers. Moreover, KRAS gene expression in women with breast tumours (benign and malignant) was not- significantly different from that seen in normal healthy women.