bluuebunny/crossref_metadata_2025 huggingface dataset:
Foreign Direct Investment and Economic Growth: Does Gross Fiscal Formation and Trade Openness Matter?
Authors: Saira Ghulam Hassan
Published: March 2024

The currents study has examined the relationship between foreign direct invest and economic growth. In addition to that the study has also examined the role of gross fixed capital formation in fostering economic growth. The study has used the data of 28 years from the period starting from 1991 to 2018. In the study, panel data estimates were used, and the most reliable results from the diagnostic test came from the fixed effect model. The technique of estimate based on panel data is the one that works well for this kind of inquiry. Panel data is desirable because it can account for and even minimize individual variation, providing lower collinearity across variables and more degrees of freedom, as well as uncover and quantify consequences. Panel data is also advantageous since it can discover and quantify causes. At the 95% confidence level, the panel unit root test reveals that all variables are stationary. This conclusion is based on the results of the test. A supplemental estimate may be obtained through the use of the fixed effects model. All of the variables that were put through their paces were found to be stable and significant at the 5% level of significance. If the Hausman test is carried out, it is generally agreed that the model with fixed effects is superior to the model with random effects, which is its counterpart. According to the results of the model with fixed effects, every variable has a significant and favorable association with GDP. A rise in foreign direct investment (FDI) is correlated with an increase in commercial activity and the formation of more stable forms of capital, both of which may drive GDP growth. GDP may be increased by a variety of means, including gross fixed capital creation, foreign direct investment, and openness; hence, each of these may also contribute to economic growth. It has been shown that there is a positive correlation between each model variable and GDP.
Do Criminality and Socioeconomic Stress Hinder Economic Development of an Emerging Southeast Asian Economy?
Authors: Suchira Mattayaphutron
Published: March 2024

The primary objective of this research is to investigate how factors such as criminal activity, social and economic pressures, and economic growth in Thailand interact with one another. In order for the study to be successful, the ARDL methodology was used. In order to conduct its analysis of the data, ARDL IV considered both the near and the far future. The work of a lot of scholars have allowed us to compile this information spanning 37 years, from 1979 to 2015. The findings demonstrated that a significant amount of focus is placed on the roles that crime serves, in particular as a barrier to the progression of economic growth. As a result of economic crime, even more money is lost, and highly skilled people are more inclined to quit their positions, making it an even more problematic situation than the gray market. The previous results imply that there is a positive association between socioeconomic stress and some features that are associated to criminal behavior. The deterrent factors, with the exception of the person's criminal background, all functioned as expected for the other variables. There was evidence to imply that there was an increase in property crime when families were unstable. The dissatisfaction, anger, and stress of the people in Thailand are represented in the socioeconomic elements that prevail in the country, as shown by the association between socioeconomic stress and variables related to crime. People come up with creative solutions to make ends meet when their quality-of-life lowers as a result of the social and economic situations in their environment. The study will help policymakers and practitioners better understand the obstacles faced by socioeconomic restrictions in emerging countries like Thailand
The Impact of Political Instability and Corruption on Saving: A Case of Selected South East Asian Countries
Authors: Waseem ul Hameed
Published: March 2024

The main objective of this research is to get an understanding of the ways in which the financial stability of ASEAN states is impacted by political instability and instances of corruption. Because corrupt government workers and political appointees siphon money that was intended for the government treasury into their own pockets instead, the amount of revenue that the government receives is reduced as a result. As a consequence, the ability of the government to put into action policies that fight against poverty and underdevelopment is hindered. Similar is the case with political instability which slow down the government machinery. The study with the aid of panel data methodology on the panel data of twenty years from 1998 -2018. Found that the corruption and political instability are in significant negative relationship with saving. In addition to that we have also investigated the impact of interaction of political instability and corruption on saving. Over all the results provided support to the prosed hypothesis. This study which is among pioneering studies on the issue will provide policy guideline to ranchers and policy makers
Exploring The Nexus Between Economic Growth, Financial Development and Co2 Emission in Gulf Countries: An Application of Environmental Kuznets Curve
Authors: Majid Ibrahim Mohammed Abdullah Al Zarooni
Published: March 2024

The main objective of the current study is to investigate the impact of economic growth, financial development (both the development and shock), and energy consumption on the CO2 emission in the selected Gulf Countries. This research study incorporates financial development as the measurement of environmental quality. In this way, it will add to the existing literature. The use of NARDL has been made in this research, which is an advanced econometric approach. An efficient way of dealing with the component of asymmetry in financial development on emissions of CO2 has been provided by NARDL with reference to the economy of Gulf countries for time 1980–2014. According to the findings of the study, the financial development, energy consumptions and GDP growth are in positive and significant relationship with CO2 emission. Thus, the findings of the study are providing support to the argument broached in the study that financial development, energy consumption and economic growth are linked with CO2 emission. The study which is among the pioneering study will be helpful for policymakers, environmental economist and researchers in explaining the impact of financial development and economic growth on environmental related issues such as CO2 emission
To Investigate the Role of Knowledge of Inclusive Finance in Intention of Inclusive Finance: The Moderating Effect of Embeddedness and Innovation.
Authors: Abaid Abaidullah , Almas
Published: March 2024

In today's contemporary landscape, it becomes imperative to integrate inclusive investment structures and pioneering financial methodologies to meet the diverse financial needs of stakeholders. Practitioners involved in devising strategies for nationwide inclusive finance expansion could find utility in this research. The study used a cross-sectional research methodology and simple random sampling techniques to analyze the responses of the current study's respondents, who are owners/investors of micro-enterprises in Punjab, Pakistan. According to the findings of the study, having knowledge of inclusive finance has a considerable favorable effect on owners' intentions about inclusive finance through the perceived benefits and dangers of ordering finance. The role of innovation is one that helps to moderate. Innovation exerts a negative influence on the relationship between PROF and owners' IIF, whereas it has a positive impact on the relationship between PBOF and owners' IIF.
‘কল্লোল’ পত্রিকার শতবর্ষ : বাংলা সাহিত্যে পালাবদলের ভূমিকা
Authors: Mallick Shankar Kumar
Published: March 2024

বাংলা ভাষায় প্রকাশিত অসংখ্য সাময়িক পত্রের মধ্যে একটি ‘কল্লোল’। ১৩৩০ বঙ্গাব্দের পহেলা বৈশাখ এর প্রম সংখ্যা আলোর মুখ দেখে। প্রম বিশ্বযুদ্ধের পর গোটা পৃথিবীতে যখন ভাঙা-গড়ার পালাবদল চলছে সেরকম সময়েই কল্লোলের আত্মপ্রকাশ। দীনেশরঞ্জন দাস, গোকুলচন্দ্র নাগ, সতীপ্রসাদ সেন-এরকম প্রাণময় কর্মনিষ্ঠ স্বপড়ব-বিভোর আত্ম-প্রত্যয়ী অথচ আর্থিক সংস্থান-শূন্য কয়েকজন তরুণ কল্লোলের ভ্রæণ তৈরি করেন। ‘কল্লোল’ শব্দের আভিধানিক অর্থকে অল্পকিছুদিনের মধ্যে সত্যে পরিণত করেছিলেন আরও বেশ কিছু প্রতিশ্রæতিশীল তরুণ কবি- লেখক-আড্ডাবাজ মানুষ। সাগরের উর্মিমালার মতো তারা বিভিনড়ব জায়গা থেকে এসে আছড়ে পড়েছিলেন ‘কল্লোল’ এর তটরেখায়। দীনেশরঞ্জন দাশের মেজোদাদার বাড়ি ১০/২ পটুয়াটোলা লেনের দু’খানা ঘরে কল্লোলের দপ্তর স্থাপিত হয়েছিল। মানিকতলায় এক বন্ধুর প্রেস থেকে প্রম কয়েকমাস পত্রিকাটি ছাপা হয়ে বেরিয়েছিল। একেবারে অনাড়ম্বর জাঁকজমকশূন্য পরিবেশে দরিদ্র ঘরের সন্তান জন্মের মতো উৎসবহীন ছিল ‘কল্লোল’ এর জন্ম। বাইরে এর ঐশ্বর্য ও জৌলুস না থাকলেও কল্লোলের সদস্যদের প্রাণোচ্ছ¡ল আনন্দ ও আবেগের ঐশ্বর্য ছিল আকাশ ছোঁয়া। মাত্র সাত বছরের আয়ুষ্কালে সেকালে ‘কল্লোল’এর সাথে রবীন্দ্রনাথ ঠাকুর থেকে শুরু করে একেবারে নবীন লেখক সকলেই প্রত্যক্ষ এবং পরোক্ষভাবে যুক্ত হয়েছিলেন। কল্লোলের লেখকরা বাংলা সাহিত্যের গতি-প্রকৃতি ও ভাবধারায় কিছু নতুন বৈশিষ্ট্য যুক্ত করতে পেরেছিলেন। মানুষের জীবন ও সমাজের অচর্চিত ও অনালোচিত বেশকিছু গুরুত্বপূর্ণ বিষয়ের দিকে আলো ফেলতে সক্ষম হয়েছিলেন। সে কারণে তাঁদের সেই স্বল্প সময়ের মধ্যে অসংখ্য শত্র এবং মিত্র উভয়ই সৃষ্টি হয়েছিল। তবে ‘কল্লোল’ পত্রিকা এবং তাকে কেন্দ্র করে গড়ে ওঠা লেখকগোষ্ঠী যারা পরবর্তীকালে ‘কল্লোলীয়’ বা ‘কল্লোল গোষ্ঠীর লেখক’ বলে পরিচিত হয়েছিলেন, তারা বাংলা সাহিত্যে স্থায়ী আসন পেয়েছিলেন। ‘কল্লোল’ পত্রিকা প্রকাশের শতবর্ষে দাঁড়িয়ে অনুভব করি বাংলা সাহিত্যে তার প্রভাব এবং সুদূরপ্রসারী গুরুত্ব।
Comparision between 3% Hypertonic Saline and 20% Mannitol in the Management of Raised Intracranial Pressure in Children
Authors: Upadhyay Sristi , Agrawal Jyoti , Kafle Shyam , Devkota Sagar , Shrestha Manju
Published: March 2024

Background Osmotic agents like mannitol and hypertonic saline are the mainstay of management of raised intracranial pressure (ICP) along with non-pharmacological measures like head elevation, hyperventilation, and hypothermia and CSF drainage. Several recent studies have shown hypertonic saline relatively superior to mannitol however, both are being used commonly. So, this study was done to compare the efficacy of mannitol and hypertonic saline in management of raised ICP in children. Methods This was a prospective randomized comparative study done among 40 children aged 1-5 years admitted in department of Pediatrics and Adolescent Medicine, BPKIHS, Dharan with clinical signs and symptoms of raised ICP They were divided into two groups based on consecutive sampling with group 1 receiving 20% mannitol and group 2 receiving 3% hypertonic saline. Results Both the groups were comparable for age distribution, gender and baseline characteristics. Pretreatment mean MAP was higher in group 2 as compared to group 1 while decrease in MAP was present in both groups at 24, 36-, 48-, 56- and 60-hours post-treatment; however, this was not statistically significant. 78.9% cases improved with mannitol while 90.5% improved with 3% hypertonic saline but this was not statistically significant. Conclusion Hypertonic saline can be an equally effective agent for management of raised ICP in children but larger and multi-centric study may help in determining which one is better.
Masculinities Inducing Deviant Sick-Role Behaviour: A Qualitative Study of Tuberculosis Patients in the Zambian Compounds
Authors: Phiri Chidongo , Mwanza Jason , Daka Harrison , Kalimaposo Kalisto , Ogah Adenike
Published: March 2024

This study aimed at obtaining an in-depth understanding of masculinities which act as barriers to performing the direct observable therapy (DOT) on the expected sick role behaviours among men who were diagnosed with pulmonary tuberculosis in Zambian compounds. The article identifies masculinities that act as gendered barriers to tuberculosis patients. It explores masculine gendered actions situated in an impoverished household. Of concern is considering both the situational aspects of gender and failure to honour the expected sick role behaviours. To do this the article used the Talcott Parson’s sick role theory whereby the behaviours, rights and responsibilities of a patient deviates from societal norms because of their disease or disorder” (DeLaune et al., 2019). Methodologically, a maximum variation sampling design was used to enlist 59 respondents. In-depth interviews were conducted with men anchored on Charmaz’s modified constructivist grounded theory informing the article. The argument in this article is that six categories of masculinities influenced deviant behaviour and accounted for reasons why and how men fail to fulfil the expected tuberculosis sick role behaviour. These categories found were: not being in control of the situation, hyper masculinity, resistance to recommended practices, masculinity stereotype threat, breadwinner and gender identities. A much closer look at the explored six categories of masculinities that effectuate deviant behaviour, the article asserts that gendered interventions are possible to neutralise sick-role behaviour among tuberculosis male patients.
Epidemiology and Risk Factors of Nosocomial Infection in Hospitalized Children and Adults: A Review
Authors: Chkhaidze Natia , Imnadze Paata , Malania Lile , Chkhaidze Ivane
Published: March 2024

Nosocomial infections (NI) or healthcare-associated infections (HAI) are infections not present at the time of admission to a hospital and manifest 48 hours after hospital admission. The specific factors contributing to the risk of infection during hospitalization remain unclear. Nosocomial infections are a growing public health threat that increases patient morbidity and mortality. Nosocomial infections (NIs) could lead to considerably longer length of the hospital stays and higher costs. Besides, the unreasonable use of antibiotics could lead to development resistance to different antibiotics and create limited therapeutic options, increased risks of treatment failure and poor patient management. These infections are a serious public health problem affecting both developed and developing countries. This study aimed to investigate the current status and changing trend of NI in various parts of the world, to provide a reference for the prevention and control of healthcare-associated infections.
Sistema de GSST para reducir el nivel de riesgo en la empresa Cerámicos San Pedro, San Pedro de Lloc, 2023
Authors: Tejeda Carbajal Jessica Karina
Published: March 2024

The present investigation has been carried out in the company Ceramicos San Pedro, in which an Occupational Health and Safety Management System was implemented, in order to reduce the level of risk. This research is of experimental design and pre-experimental type. The investigation begins with the recognition of the current situation of the company, through the guidelines of Law No. 29783 (Check List), afterwards, the SGSST is implemented. Finally, we proceed to carry out the second measurement of the Check List tools and the IPERC matrix, this in order to be able to corroborate and compare the results obtained before and after implementing the GSST System. The GSST System implemented in Ceramics San Pedro has managed to reduce risk levels, the most notorious being intolerable and important risks in their total reduction, 49% moderate risks and 51% tolerable risks. In addition, it allowed most of the guidelines based on Law 29783 to be fulfilled.
El Pensamiento Esbelto y la calidad educativa en la Educación Superior
Authors: Paco Vargas Marco Antonio
Published: March 2024

In a globalized and avant-garde world like this one, where the demands for excellence are the order of the day, Lean Thinking has emerged. Although its origins come from the manufacturing area, it has permeated in such a way that this philosophy is perfectly applicable to the academic campus. The objective of this research is to analyze how the application of lean thinking can contribute to raising the quality of teaching in higher education institutions. Methodologically, the study was based on a descriptive-correlational level with a purely documentary design. The conclusions point out that this methodology has a positive impact on the efficiency and quality of education, showing improvements in pedagogical processes, quality of learning, student satisfaction and innovation. Additionally, an experience of implementation of Lean Thinking in a Bolivian Higher Educational Institution was described, which obtained extraordinary results.
Factors Affecting Mathematics Students at Jambi University Being Infected with Covid-19 Using Binary Logistic Regression
Authors: Ivone Damanik Ellys , Kholijah Gusmi , Multahadah Cut
Published: March 2024

Pandemi global COVID-19 menimbulkan tantangan serius bagi kesehatan masyarakat, termasuk di kalangan mahasiswa. Temuan ini bertujuan untuk memahami faktor-faktor yang mempengaruhi tingkat infeksi COVID-19 di kalangan mahasiswa Matematika Universitas Jambi, dengan fokus pada persepsi keefektifan tindakan isolasi diri ataupun karantina mandiri. Temuan ini bertujuan untuk membentuk model regresi logistik biner yang dapatlah menganalisis faktor-faktor yang mempengaruhi mahasiswa Matematika Universitas Jambi terinfeksi COVID-19. Faktor yang dipertimbangkan meliputi kepatuhan terhadap protokol kesehatan, reaksi terhadap keadaan wabah, persepsi terhadap isolasi diri, kekhawatiran saat berpergian, jenis kelamin, serta jumlah orang yang tinggal serumah. Data primer diperoleh melalui distribusi kuesioner online kepada mahasiswa Program Studi Matematika Angkatan 2020-2022 di Universitas Jambi. Metode Cluster Random Sampling dipergunakan untuk pengambilan sampel. Proses analisis data melibatkan regresi logistik biner dengan estimasi maksimum likelihood (MLE), uji serentak, serta uji parsial mempergunakan uji Wald. Model terbaik diidentifikasi dengan metode Backward. Hasil analisis menunjukkan bahwasanya variable yang signifikan ialah persepsi keefektifan tindakan isolasi diri ataupun karantina mandiri (X3). Model regresi logistik tereduksi menjadi π(x) = exp(-7,731 + 1,480X3) / (1 + exp(-7,731 + 1,480X3)). Odds ratio untuk X3 ialah 3,571, menunjukkan peningkatan peluang tidaklah terinfeksi COVID-19 sebanyak 3,571 kali dengan persepsi positif terhadap tindakan isolasi diri.
Digital generation online shopping users: not a secret for generation z
Authors: Yulandari Ariefah
Published: March 2024

Impulse buying is often a label for generation Z. This study was carried out to test the influence of sentiment polarity and observational learning on online impulsive buying moderated by impulsive buying tendencies. This research takes data from generation Z who live in the city of Solo who buy online. The sample obtained was 96 respondents and tested using logistic regression analysis. It was found that sentiment polarity has no effect on online impulse buying and impulse buying tendency is an ordinary independent variable that has an independent effect on impulse buying. In contrast, observational learning has a positive effect on online impulsive buying, while the impulsive buying tendency variable does not moderate the relationship between sentiment polarity and observational learning on online impulsive buying.
INTELLECTUALISATION OF THE STAFF OF LOCAL SELF-GOVERNMENT BODIES OF TERRITORIAL COMMUNITIES OF UKRAINE AS A NECESSARY COMPONENT OF THEIR PROFESSIONALISATION
Authors: ARABCHUK Yaroslav , KOLISNYK Mykola , KULIKOVSKYI Roman , KHAMCHUK Hryhorii
Published: March 2024

In the article, based on a comparative analysis of the content of the concepts «intellectualization» and «professionalization», the inseparability of these concepts is demonstrated, of which the first concept is a formative asset, and the second is the expected consequence, which is an increase in the professionalism of employees of local self-government bodies of territorial communities of Ukraine. As a result of this analysis, a logical and grapho-analytical model of the professionalism of employees of a local self-government body as an elementary carrier of intelligence (IEN) was proposed, the mandatory conditions for the effective and efficient use of which are the employee's possession of thinking technologies (TMEN), technologies of involving other people's intelligence into cooperation (TZEN), as well as digital technologies and equipment, including artificial intelligence (ТАІ). This approach opens up the possibility of creating and using a new model of professionalism, focused on the continuous development of the intelligence of managerial personnel based on a person-oriented approach to the intellectualization of their work, taking into account the peculiarities of the individual intelligence of each individual and arming it with modern digital technologies for the formation of professional suitability, competence and experience.
PECULIARITIES OF LEGAL SUPPORT FOR THE FUNCTIONING OF THE CIVIL PROTECTION SYSTEM IN THE EU COUNTRIES
Authors: MALIMON Vitalii , POMFIUK Taras
Published: March 2024

The article analyses the peculiarities of legal support of the European system of civil protection of population and territories. The author emphasizes that over the years, the EU has developed the main instruments through which all of its civilian security policy objectives are achieved.

It is proved that building a modern and powerful civil defence system of the population and territories of Ukraine requires even more close cooperation with the relevant European structures, including within the framework of the European Union Civil Protection Mechanism (EU Civil Protection).

The priorities of the EU's civil protection programs are to enhance cybersecurity and a safer online environment through the development and effective use of the digital capabilities of the European Union and its Member States. Significant attention is paid to supporting data and network protection, which strives for technological sovereignty while respecting privacy and other fundamental human rights. Joint European projects contribute to ensuring the security of services, processes and products, and ensure the formation of reliable digital infrastructures that can withstand and counter cyberattacks and hybrid threats.

The study of the peculiarities of Ukraine's cooperation with the EU in the field of civil protection allows us to state that Ukraine's accession to the EU Civil Protection Mechanism will allow it to fully use all EU instruments and programs to develop the national civil protection system and attract assistance, and to continue future cooperation within the framework of the new strategic program of the EU Civil Protection Mechanism for 2024-2027.

The peculiarities of using the experience of the EU countries to develop a system for ensuring public safety and protection of critical facilities during emergencies in Ukraine will be determined by the transformation of the public administration system in the post-war period.
IMPROVING THE MECHANISMS OF SERVICE PROVISION BY THE PENSION FUND OF UKRAINE
Authors: TOLUBIAK Vitaliy , KULCHII Inna
Published: March 2024

The article discusses the range of services provided by the Pension Fund of Ukraine through the web portal for pensioners, insured persons and policyholders. The essence and necessity of creating a barrier-free space for the provision of services in government bodies is substantiated. It is noted that barrier-freeness is a concept that applies to absolutely all spheres of life. This is not only physical barrier-free space and buildings, but also barrier-free services, information, services and goods.

The importance of digitization of services in the field of pension provision is revealed, which, among other things, helps to overcome the human factor, queues and corruption. Receiving services in digital format on the web portal of the Pension Fund of Ukraine is convenient and safe. Digitization of services based on the use of information and communication technologies contributes to increasing the efficiency, openness, barrier-freeness, transparency of the activities of state authorities at all levels and contributes to the formation of a new type of state focused on meeting the needs and requests of citizens.
Las Cooperativas Agrarias Centenarias en Catalunya: Características y contribución a los ODS
Authors: Montegut Yolanda , Colom Antonio , Plana-Farran Manel
Published: March 2024

Las cooperativas agrarias de Catalunya se caracterizan por tener una extraordinaria longevidad, siendo más de una cuarta parte de las mismas las que han alcanzado el siglo de supervivencia y funcionamiento (Anuari Socioeconòmic de la Federació de Cooperatives Agràries de Catalunya, FCAC, 2022, 2021 y 2020). A pesar de esta perdurabilidad, estas organizaciones se han visto obligadas a afrontar importantes cambios (evolución del sector agrario, cambios de los gustos de los consumidores, exigencias gubernamentales, mecanización y modernización del sector agrario), así como dar respuesta a dificultades estructurales como la dimensión, el envejecimiento y la renovación generacional, entre otros.Como una estructura fundamental de la Economía Social, las cooperativas desarrollan su actividad bajo las premisas de los valores y principios cooperativos, convirtiéndose en actores esenciales en el cumplimiento de los Objetivos de Desarrollo Sostenible (ODS) (Villaescusa, 2019) aprobados en el marco de la Asamblea General de Naciones Unidas en septiembre de 2015. Refiriéndose a las cooperativas agroalimentarias, Mozas y Bernal (2020) las destacan como aquellas entidades que constituyen la columna vertebral de la Economía Social, representando uno de los instrumentos básicos del desarrollo rural (Gallego, 2007).La propuesta que realizamos en este trabajo es la siguiente: el cooperativismo agrario muestra una longevidad que requiere de un análisis pormenorizado a fin de determinar los elementos que contribuyen a la misma y que, de una forma tácita contribuye al cumplimiento de algunos de los ODS (4, 9, 12, 16 y 17). Para conseguir estos objetivos de investigación, utilizamos la Teoría del Capital de Bourdieu (1986).
ТHE SIGNIFICANCE OF CERULOPLASMIN AND C-REACTIVE PROTEIN AS POSSIBLE MARKERS FOR THE DIAGNOSIS OF MYXOBOLOUS INFECTION CAUSED BY Myxobolus cerebralis IN RAINBOW TROUT (Oncorhynchus mykiss)
Authors: ZAPRYANOVA Dimitrinka , URKU Cigdem , NIKOLOV Galin , ATANASOFF Alexander
Published: March 2024

Myxobolus cerebralis is the etiological agent of one of the most devastating diseases (Whirling disease) in salmonids. It belongs to subphylum Myxozoa which possesses the highest susceptibility to the rainbow trout (Oncorhynchus mykiss). Acute phase proteins as an essential component of normal homeostasis are well defined and are presently used as a diagnostic and prognostic marker in human and animal pathology for evaluation of infection and inflammation. In piscine medicine the importance and the function of acute phase proteins still has not been fully determined. Furthermore, parasitic infections are more difficult to diagnose than bacterial and viral infections due to the lack of specific diagnostic tools therefore the change in the levels of some acute phase proteins could possibly be used as an alternative marker for myxobolosis. Further research is still needed to develop an understanding of the diagnostic significance of acute phase proteins in fish and the differentiation of their values in different types of disorders. The present study evaluated the modulation of ceruloplasmin and C-reactive protein following inflammatory stimulus by natural infection of Myxobolus cerebralis in rainbow trout (Oncorhynchus mykiss). In the research, biochemical tests and enzyme-linked immunosorbent assay were carried out. The test material was a diseased rainbow trout with a mortality rate of 45%. In the future, acute phase proteins have a real potential to become widely used as diagnostic tools in piscine medicine, as the evaluation of their levels can help better diagnosis and treatment, especially when it occurs during illness. Measurement of C-reactive protein concentration in trout may be used useful as a bioindicator of the health condition of this species. Further research is still needed to develop an understanding of the diagnostic significance of acute phase proteins in fish and the differentiation of their values in different types of disorders.
SENSITIVITY OF BACTERIAL STRAINS ISOLATED IN CASES OF COW MASTITIS TO ANTIBIOTICS AND ESSENTIAL OILS
Authors: HUREMOVIĆ Sajma
Published: March 2024

Mastitis is an inflammatory reaction of the udder caused by microorganisms, chemical or mechanical injuries. Bacterial mastitis, caused by several types of bacteria, is divided into two main groups: contagious mastitis caused by Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysgalactiae, Mycoplasma bovis and mastitis caused by the ubiquitous bacteria Escherichia coli, Pseudomonas aeruginosa or Proteus spp. Currently, instead of using antibiotics, new strategies are being sought to reduce this clinical health problem. The aim of this study is to determine the sensitivity of bacterial strains causing mastitis to antibiotics and essential oils of oregano (Origanum compactum, Origanum majorana) and thyme (Thymus serpyllum). Mammary gland secretion samples, obtained by mechanical and manual methods, from dairy cows from the Kalesija and Gradačac areas were used. A total of 200 samples from dairy cows in different periods of lactation and age were examined. Mastitis control included determining somatic cells count in milk with the California mastitis test, or counting somatic cells on the Fossomatik apparatus, after which all samples with an increased number of somatic cells were microbiologically tested. Based on the obtained results, it can be concluded that there are justified reasons why the use of essential oils should be considered as an alternative to the use of antibiotics in the therapy of animals suffering from mastitis.
PATHOGENESIS OF LAMINITIS IN DAIRY COWS
Authors: BOJKOVSKI Jovan , NEDIĆ Sreten , ARSIĆ Sveta , VUJANAC Ivan , PRODANOVIĆ Radiša , MITROVIĆ Aleksandra , ĐURIĆ Miloje , BUGARSKI Dejan , PANOUSIS Nikolaos K. , KALAITZAKIS Emmanouil , NINKOVIĆ Milan
Published: March 2024

The lameness is the earliest but also the most important clinical symptom of the achropodium diseases in cattle. According to literary data, in 90% of cases, the cause of lameness is localized in the hooves, and in 10% of cases it is in other anatomical parts of the limb. In 88% of cases, the pathological process has been manifested at the hind limb. Laminitis is an aseptic inflammation of the corium of the hooves. In addition to the mechanical overloading of the hooves, the toxic causes are also addressed as the causes of this disease. Longer feeding with rapidly digested concentrate, rumen acidosis, sudden change of food components, especially diet with green barley, oat, freshly harvested young legumes and nutrition with molded food, can lead to laminitis. Laminitis is often the result of impact of a large number of factors, such as metabolic and digestive disorders, calving stress, mastitis, metritis, abomasal displacement, bedding without or with very little straw, inability to move, obesity and poor diet. The ration that leads to acidosis also leads to laminitis. Such a ration is difficult to correct in a case when the carbohydrates are present in highest percentage. Vasoactive substances (histamine), which enter the bloodstream from rumen, are considered to lead to damage of the hoof corium. Metabolic disorder is caused by a low pH of rumen, which leads to pathophysiological disorders, which eventually result in the ischemia of the hoof corium and clinically manifest laminitis (leg disposal due to pain, and sometimes forced lying). In addition to histamine and bacterial endotoxins, milk acids and other biologically active substances are believed to contribute to the onset of this disease. The application of basic principles of the nutrition of the lactating cows can prevent the appearance of laminitis and therefore the appearance of economic losses due to lameness.
ВОДА У ИНДУСТРИЈИ ХРАНЕ – МИКРОБИОЛОШКИ ОСВРТ
Authors: ГОЛИЋ Бојан , НЕДИЋ Драго Н. , ПЕЋАНАЦ Биљана
Published: March 2024

Вода се користи на различите начине у производњи хране, чиме постаје дио хране. Вода за прање у прехрамбеној индустрији може бити извор бактеријске контаминације и додатно угрозити квалитет и безбједност хране. Истраживањем су обухваћени узорци воде која се користи у прехрамбеној индустрији. Испитивање обухвата 192 узорка, од којих је 75% из водовода, а 25% из бунара. Лабораторијско испитивање воде вршено је методама BAS EN ISO 6222, BAS EN ISO 9308 и BAS EN ISO 7899-2. Циљ истраживања је утврђивање микробиолошког статуса воде у прехрамбеној индустрији. Истраживањем је утврђено 79,69% задовољавајућих узорака и 20,31% незадовољавајућих узорака воде. У односу на испитиване параметре, у 12,50% узорака утврђен је повећан број микроорганизама на 22°С, а у 10,42% узорака утврђен је повећан број микроорганизама на 37°С. Када су у питању индикатори хигијене, 8,85% незадовољавајућих узорака је било због присуства цријевних ентерокока, а 5,73% незадовољавајућих узорака због присуства Escherichia coli и колиформа. С обзиром на присуство колиформних бактерија, Escherichia coli и цријевних ентерокока у води која се користи у прехрамбеној индустрији, постоји ризик од микробиолошке контаминације хране путем воде. Ово је посебно значајно с обзиром на удио бунарске воде у односу на укупну воду која се користи у индустрији хране.
ИСТРАЖИВАЊЕ О МИШЉЕЊУ СТУДЕНАТА ПРВЕ И ЗАВРШНЕ ГОДИНЕ ФАКУЛТЕТА ВЕТЕРИНАРСКЕ МЕДИЦИНЕ О ПРАВИМА И ДОБРОБИТИ ЖИВОТИЊА
Authors: ДАВИТКОВ Дајана , ВЕЈНОВИЋ Бранислав , ЈОВАНОВИЋ Вишња , ДАВИТКОВ Дарко , ШОЛАЈА Софија , АЛЕКСИЋ РАДОЈКОВИЋ Јелена
Published: March 2024

У данашње време улога животиња у друштву је промењена. Животиње се више не посматрају као власништво, већ као жива бића. Када је у питању ветеринарска медицина, такође постоје промене у интересовањима између мушкараца и жена, као и професионалним преференцијама. Студије су показале да пол и брига за добробит животиња такође утичу на ниво забринутости за здравље животиња. Циљ овог истраживања био је да се процени разлика у мишљењу између студената прве и завршне године ветеринарске медицине у односу на етичке дилеме и добробит животиња. У истраживање је укључено укупно 200 студената ветеринарске медицине прве и завршне године. Survey Monkey је коришћен за прикупљање информација, а анкета се састојала од десет питања. Резултати су подељени на демографске податке, етичке дилеме у области права животиња и мишљење о еутаназији. Није установљена статистички значајна разлика између односа полова и места одрастања испитиваних студената. Скоро половина студената прве године (49%) исказала је жељу да ради са социјалним животињама, а само 11% са фармским животињама. Када је реч о студентима завршне године, већина њих такође жели да ради са социјалним животињама (36%), али постоји и интересовање за рад са фармским животињама (20%). На разлике у мишљењу о правима животиња и еутаназији више је утицао пол студената у поређењу са годином студија. Истраживање је показало да у популацији студената постоји смањена заинтересованост за бављење праксом фармских животиња, и да је то област којој треба посветити више пажње. Такође, неопходно је више усмеравати студенте за области њиховог интересовања током студирања, да би када стекну диплому могли одмах знати у којој области ветеринарске делатности желе да раде.
OSJETLJIVOST BAKTERIJSKIH SOJEVA IZOLOVANIH U SLUČAJEVIMA MASTITISA KRAVA NA ANTIBIOTIKE I ETERIČNA ULJA
Authors: HUREMOVIĆ Sajma
Published: March 2024

Mastitis je upalna reakcija vimena koju uzrokuju mikroorganizmi odnosno hemijske ili mehaničke povrede. Bakterijske mastitise uzrokuje nekoliko vrsta bakterija, koji se dijele u dvije glavne grupe: kontagiozni mastitisi uzrokovani sa Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysgalactiae, Mycoplasma bovis i mastitisi uzrokovani ubikvitarnim bakterijama Escherichia coli, Pseudomonas aeruginosa ili Proteus spp. Trenutno se umjesto upotrebe antibiotika traže nove strategije za smanjenje ovog kliničkog zdravstvenog problema. Cilj ovog istraživanja je utvrđivanje osjetljivosti bakterijskih sojeva uzročnika mastitisa na antibiotike i eterična ulja origana (Origanum compactum, Origanum majorana) i timijana (Thymus serpyllum). Tokom ispitivanja korišteni su uzorci sekreta vimena muznih krava sa područja Kalesije i Gradačca, dobiveni mašinskim i ručnim načinom. Ispitano je ukupno 200 uzoraka mliječnih krava u različitim periodima laktacije i starosti. Kontrola mastitisa obuhvatala je određivanje broja somatskih stanica u mlijeku Kalifornija mastitis testom, odnosno brojanje somatskih stanica na Fossomatik aparatu, nakon čega su svi uzorci sa povećanim brojem somatskih stanica mikrobiološki ispitani. Na osnovu dobijenih rezultata ispitivanja može se zaključiti da postoje opravdani razlozi zbog kojih treba razmotriti upotrebu eteričnih ulja kao alternativu upotrebe aantibiotika u terapiji životinja oboljelih od mastitisa.
ВЕРИФИКАЦИЈА И ПРОЦЈЕНА МЈЕРНЕ НЕСИГУРНОСТИ HPLC МЕТОДЕ ЗА УТВРЂИВАЊЕ КОЛИЧИНЕ ХИСТАМИНА У РИБИ И ПРОИЗВОДИМА ОД РИБЕ
Authors: АНИЧИЋ Јелена , ГОЛИЋ Милијана , ПЕЋАНАЦ Биљана
Published: March 2024

Циљ рада је приказати експерименталне резултате добијене при верификацији HPLC методе утврђивања садржаја хистамина у риби и производима од рибе за три врсте риба и производа од рибе и процијењену мјерну несигурност методе. Метода за утврђивање количине хистамина у риби и производима од рибе верификована је према BAS EN ISO 19343:2017. Оцијењени су сљедећи параметри верификације методе: утицај матрикса/линеарност, лимит квантификације, тачност, прецизност и процијењена је мјерна несигурност методе за три врсте рибе (туну, скушу и сардину). Доказана је линеарност у распону концентрација од 0 mg kg-1 до 500 mg kg-1 са коефицијентима корелације од 0,9925 до 0,9999. Лимит квантификације за све три врсте рибе износи 10 mg kg-1. Тачност је оцијењена анализом контролних материјала преко искориштења и просјечна вриједност износи 96,61%. Прецизност је оцијењена у условима поновљивости и обновљивости на три концентрациона нивоа за три врсте рибе и изражена је као лимит поновљивости r и лимит обновљивости R. Лимити обновљивости R за туну износе 15,96 до 24,89%, за скушу 12,80 до 23,04%, а за сардину од 10,25 до 32,17%. Мјерна несигурност процијењена је на три концентрациона нивоа 25 mg kg-1, 100 mg kg-1 и 220 mg kg-1 и износи респективно за туну 17,78 mg kg-1, 11,40 mg kg-1 и 13,88 mg kg-1, за скушу 16,46 mg kg-1, 12,56 mg kg-1 и 9,14 mg kg-1, а за сардину 22,98 mg kg-1, 12,70 mg kg-1 и 7,32 mg kg-1. Добијени резултати параметара верификације усаглашени су с прописаним и препорученим критеријумима прихватљивости, те потврђују да је метода испитивања довољно поуздана и лабораторија је може користити у рутинском раду.
Attitude to the child's illness and parental burnout of women raising children with autism spectrum disorders
Authors: Kuzmina Anna Sergeevna , Krivoshei Kristina Olegovna
Published: March 2024

The subject of the study is the parental burnout of women raising children with autism spectrum disorders. Special attention is paid to the type of attitude to the mother's child's illness and her emotional burnout. The aim of the study is to identify the relationship of parental burnout with the type of attitude to the child and his illness in women raising children with autism spectrum disorders. Theoretical analysis of scientific research on the problem of emotional burnout of parents raising children with autism spectrum disorder allows us to conclude that each family faces huge problems of a different nature, which leads to chronic stress, flowing into emotional burnout. Different types of attitudes to the disease can aggravate this condition. The main conclusions of the study are presented in the provisions. Parental burnout of women raising children with autism spectrum disorders is determined by the peculiarities of emotional relationships with the child. Data were obtained on different relationships between the symptoms of parental burnout and the type of relationship with a child of different ages. Emotional exhaustion, depersonalization, reduction of parental achievements are interrelated with the peculiarities of contact with the child, the inability to understand the child, feelings arising in interaction with the child, the inability to provide emotional support to the child. The type of attitude to the child's illness is determined by the peculiarities of the emotional relationship between mother and child. Thus, the predictors of the types of attitude to the child's illness are the feelings that arise in the mother's relationship with the child, a negative attitude towards herself as a mother, unconditional child, restrictions on activity and physical contact.
The professor on the (online) campaign trail
Authors: Harmon Mark
Published: March 2024

Part campaign diary, part how-to guide, this book is the story of the 2022 congressional campaign of University of Tennessee, Knoxville, journalism professor Mark Harmon. Harmon attempted something no East Tennessee Democrat has done since William Montgomery Churchwell in 1855—represent the Knoxville area in Congress. Harmon had scored an upset in a 2006 bid for Knox County Commissioner and hoped to do so again against the deep-pocketed Republican incumbent, Congressman Tim Burchett. With a volunteer campaign manager and treasurer, and in-kind donations of photography and video services, Harmon relied heavily on local presence at community events in a vigorous ground game supplemented creatively with Facebook and Insta-gram. Grassroots in format as well as content, this open-access ebook makes ample use of images and film clips to give a street-level view of a homegrown campaign.”—Provided by the publisher.
In silico approaches which are used in pharmacy
Authors: Al-Mohaya Mazen , Mesut Burcu , Kurt Asena , Çelik Yavuz Selim
Published: March 2024

This mini-review theoretically illustrates the in silico methods used in the pharmacy field to enhance drug discovery and development and reduce preclinical studies. It is shown that in silico methods are computational-based approaches that study the structure, properties, and activities of molecules using computer simulations and mathematical algorithms. These results highlight the importance of obtaining data that can affect the prediction of in vivo results. Artificial intelligence and machine learning development enhance in silico methods such as quantitative structure-activity relationship, molecular placement, and physiological-based pharmacokinetics, which are usually used. This approach not only saves time and costs but also offers ease of application. Studies conducted to evaluate the use of in silico methods in areas such as pharmacology, toxicology, and pharmaceuticals are provided as examples. It was concluded that over time, in silico methods usage and development increased due to their ability to predict the in vivo performance of the drug.
Formulation and in-vitro evaluation of electrospun micorfibers for enhanced solubility of Olmesartan medoxomil
Authors: Sisinthy Sreenivas Patro , Chai Siew En , Majeed Shahnaz , Izzati Mat Rani Nur Najihah
Published: March 2024

Olmesartan medoxomil (OLM), which is a biopharmaceutical classification system class II drug has low aqueous solubility, resulting in its poor bioavailability and therapeutic efficacy. In this present study, OLM was formulated into electrospun microfibers to enhance its aqueous solubility and dissolution rate. OLM-loaded microfibers were formulated by using the electrospinning method using Eudragit RS 100 and Soluplus as carriers. The physicochemical characteristics of microfibers were evaluated by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), drug content uniformity and in vitro dissolution studies. SEM and DSC analysis suggested that the electrospun microfibers were uniform and OLM is dispersed in an amorphous state. FTIR analysis showed no incompatibility between the drug and polymers in the microfibers. OLM content in the prepared OLM-loaded microfibers with Eudragit RS 100 and Soluplus was found to be 96.93 ± 0.03% and 93.67 ± 0.05% respectively. In vitro, dissolution concluded that Soluplus and Eudragit RS 100 increased OLM’s dissolution rate by three-fold and two-fold respectively. In conclusion, OLM had good compatibility with both the carriers and OLM’s dissolution rate was remarkably enhanced by formulating electrospun microfibers with Eudragit RS 100 and Soluplus.
Automatic fabrication system of optical micro-nanofiber based on deep learning
Authors: Liu Hong-Jiang , Liu Yi-Fei , Gu Fu-Xing ,   School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
Published: March 2024

The wide range, high precision, and dynamic real-time measurement of micro-/nanofiber diameter are crucial for achieving low loss transmission and controlling dispersion in the preparation process of micro-nanofiber. In view of the problems of small diameter regulation range, complex operation and long-time consumption of the existing preparation methods, the automatic detection system of micro-nanofiber is realized based on deep learning neural network algorithm in this work. The image segmentation method in computer vision is used to make high-quality multi-scale micro-/nanofiber datasets, and the improved YOLOv8-FD (You Only Look Once version 8-Fiber Detection) algorithm based on small target detection is used to automatically detect the diameter of micro-nanofiber.

Through image segmentation and identification of the target of single pixel size in the microscopic image, the diameter detection of micro-nanofiber is finally realized. In this process, the real-time diameter of micro-nanofiber is obtained through image information, and then the micro-nanofiber small target is accurately segmented to achieve the precise detection of mAPIoU=50 = 0.975 and mAPIoU=50—95 = 0.765 on the micro-nanofiber multi-scale target dataset with extremely high accuracy. The algorithm-based construction of a high-precision micro-nanofiber automatic preparation system enables real-time accurate segmentation of fiber edges, calculation of fiber diameter, and feedback to the control system for achieving automated preparation of fibers with arbitrary diameters. Additionally, it facilitates the detection of micro-nanofiber in a range from 462 nm to 125 μm. The average response time for reasoning is 9.6 ms, and the detection error is kept below 2.95%.

In addition, compared with other micro-/nanofiber diameter detection methods based on optical imaging and mode cutoff, this method shows advantages of high precision, high speed and arbitrary diameter preparation for diameter detection based on deep learning neural networks. The system is very suitable for high-precision real-time measurement and automatic and accurate preparation of micro-/nanofibers, thereby providing a novel method of developing micro-nanofiber devices with low-loss transmission and adjustable dispersion.