bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of anti-diabetic potential of Sceletium tortuosum aerial parts against streptozotocin-induced diabetes on wistar rats
Authors: S. Kameshwaran  , P. Hemadharsni  , S. Deepanchakkaravarthi
Published: January 2025

Diabetes Mellitus, the metabolic syndrome where the body either fails to produce or effectively utilize insulin, is associated with chronic morbidity. While a definitive cure for the disease is lacking, with the modern medicine offering mainly the means to control the extent of the disease, Complementary and Alternative Medicine (CAMs) offers additional/alternate means to tackle the disease. On the other hand, the lack of evidenced medical practices is a lacuna in most of the traditional medical applications. Sceletium tortuosum (Aizoaceae family), a perennial shrub found in the tropics, has been known for its numerous pharmacological properties and is found as a constituent in many Ayurvedic and Siddha drugs. Any evidence based evaluations have not been conducted on the anti-hyperglycemic effect of the plant. In the current study, the ethanolic extract of S.tortuosum, was scientifically assessed for its effect on In-vitro α-amylase inhibition assay, In-vitro α-glucosidase inhibition assay, In vitro anti-glycation assay and In-vivo anti-diabetic activity by streptozotocin induced diabetes in Wistar albino rats. The diabetic rats were divided into 5 groups of 6 animals each. For testing the efficacy of extracts, two groups were intra-orally provided with dosages of 100 mg/Kg and 200 mg/ Kg of body weight of animals, respectively, ofEthanolic extract of S.tortuosum. Control groups were maintained for evaluation, which included vehicle control as well as with Glibenclamide, a standard anti-diabetic drug. The extracts at a dose of 400 mg/Kg body weight was found to be associated with significant amelioration of many of the diabetes induced conditions, suggesting that the plant extract could be a strong potential CAM candidate for therapeutic management of diabetes.
Comparison Effects of Giving Iron 60mg Folic Acid 0.4 mg Day And Iron 120 mg Folic Acid 2.8 mg Week On Hemoglobin Levels, Side Effects In Pregnant Women In Trimesters II-III And Fetal Welfare
Authors: Desiska Pricilia Tumatar  , Krisdiana Wijayanti  , Bedjo Santoso  , Ari Suwondo  , Melyana Nurul Widyawati
Published: January 2025

Background: Iron plays an essential role during pregnancy. However, pregnant women who use it daily may experience negative effects. There are suggestions that can be taken to reduce discomfort associated with iron consumption by administering weekly.
Destination: Researchers analyzed the difference between daily and weekly iron and folic acid administration on hemoglobin levels, side effects and fetal well-being.
Method: This study utilized a quasi-experimental, pretest-posttest, two-group design. 40 pregnant women in their second or third trimester were divided into two groups, each containing 20 participants: the group receiving iron 60 mg folic acid 0.4 mg per day and the group receiving iron 120 mg folic acid 2.8 mg per week. Examination of hemoglobin levels was performed once per month for three months during the intervention, while evaluation of side effects was done once per week and monitoring of fetal well-being was conducted at the beginning of the intervention and three months following the intervention.
Results: Result of hemoglobin level test using repeated measure ANOVA, administering 60 mg of folic acid 0.4 per day (0.012), and administering iron 120 mg of folic acid 2.8 mg per week (0.000), side effects using mcNemar test (0.125 nausea and vomiting 0.250 constipation) daily administration (0.625 nausea and vomiting 0.500 constipation) weekly administration, and fetal well-being using the Wilcoxon 0.000 test for daily administration, 0.000 for weekly.
Conclusion: Iron tablets can be administered weekly as an alternative to prevent oxidative stress and reduce digestive discomfort in pregnant women.
Coloncare capsules - A Perfect Blend of Pro-prebiotics stimulate our Immunity in response to pathogen Infections
Authors: GovindShukla  , Chandramauli  , Balaswamy N.G  , Rajkumar  , C.J. Sampath Kumar
Published: January 2025

A Probiotic is defined classically as a viable microbial dietary supplement that beneficially affects the host through its effects in the intestinal tract. This definition, however, was initially intended for use with animal feed products. For human nutrition, the following definition has been proposed. A live microbial food ingredient that is beneficial to health. A Prebioticis defined as “a nondigestible food ingredient that beneficially affects the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon. The present paper Reviews the Role of Colon care capsules, A perfect blend of 2 prebiotics & 6 Probiotics  to mentain healthy gut flora, developed by R&D cell of Lactonova Nutripharm Pvt Ltd. Hyderabad.
A Prospective Study on Assessment of the Drug Interventions during Ward Rounds in the Department of General Medicine at a Tertiary Care Hospital.
Authors: Veena Gadicherla  , Varun Dasari  , Perli Kranti Kumar  , Naga Latha Dhulipalla
Published: January 2025

The aim of the present study was a prospective study on assessment of the drug interventions during ward rounds in the department of general medicine at a tertiary care hospital. Out of 18 drug need not prescribed were 3(16.66%), inappropriate dosage form were 6(33.33%), wrong dose taken were 1(5.55%), dose too low were 3(16.66%), dose too high were (5.55%) and duration of treatment inappropriate were 4(22.22%). Highest number of interventions identified were minor 48.71%. Having highlighted the importance of clinical pharmacist in this study, a multidisciplinary team approach is required to effectively minimize the potential of drug related problems. Furthermore, the high degree of acceptance by prescribers encourages clinical pharmacists to continue their service and to extend it to other wards and departments. The present results point to the establishment of drug related problem reporting system at each hospital and to share data with other hospitals healthcare settings. Participation and interventions of clinical pharmacists in health care positively influence clinical practice. Many studies have monitored interventions in clinical areas to provide quantitative and qualitative data on pharmaceutical input.
Artificial intelligence in pharmacy
Authors: SK. Farahan Subahan  , J. N. Suresh Kumar  , Chimata. HanumanthaRao  , Chuppana. Naga Veera Durga Sai Madhurya  , Dudekula. Sajeedha  , Gurrapusala. Lakshmi Venkata Surekha  , Sheik. Nageena Bee
Published: January 2025

A branch of computer science called artificial intelligence makes it possible for machines to function well. By taking on complex data processing Duties, its use in pharmaceutical technology has grown, improving workflow efficiency, lowering operating cost, and promoting safety, accuracy, and Productivity. It could Potentially save time and money in addition to assisting us in better understanding the connections Between various formulations and process parameters. Artificial intelligence (AI) research has been shown to be able to analyze and interpret various critical pharmacy fields, including drug development dosage forms design, and hospital pharmacy. Thanks to artificial intelligence’s significant contributions to the management and preservation of data and information, the healthcare industry has seen impressive advancements
Efficacy Of Abdominal Exercises With And Without Elastic Therapeutic Taping In Reducing Diastasis – Recti Among Post-Partal Females
Authors: Vishakha Kadam  , Mithila Pawar  , Janvi Rajpal
Published: January 2025

Pregnancy induces significant physical and mental transformations. The expanding uterus and fetus exert increased pressure on the abdominal muscles and connective tissues. These forces often cause the linea alba to stretch and occasionally split, leading to diastasis recti. Diastasis recti can contribute to lower back pain and strain due to overworked or compensatory muscles, unstable core, pelvic and back muscles, poor posture, shallow breathing, and uterine prolapse. The aim of this study was to assess the efficacy of abdominal exercises alone and abdominal exercises combined with elastic therapeutic taping in reducing diastasis recti in postpartum females, and to compare their respective effects. Thirty postpartum females were randomly assigned to two groups- control and taping group with fifteen females in each group. Control group was provided with conventional exercises like Static abdominal exercise, Head lift, Head lift and pelvic tilt, Pelvic clock exercise which were to be done twice a day with a repetition of 5-7 times for a duration of 4 weeks. Another group of was given exercises in addition to elastic therapeutic taping. Tape was applied in a crisscross design, beginning just below the breast and extending to the superior pubis, twice a week for 4 weeks on the rectus abdominis. Ultrasonography was used to measure diastasis recti before and after the study. The result showed that conventional exercises, as well as conventional exercises combined with taping, are effective in reducing diastasis recti in postpartum females. However, it is found that taping in conjunction with conventional exercises is more effective.
To study the effect of Different Positions on FVC and FEV1 measurements in Obstructive Pulmonary Disease Patients.
Authors: Payaswini Daithankar  , Vishakha Kadam  , Mithila Pawar
Published: January 2025

Obstructive diseases include conditions in which there is a resistance to airflow either through reversible factors such as bronchospasm or inflammation, or through irreversible factors such as airway fibrosis or loss of elastic recoil owing to damage to the airways and the alveoli. Types include: COPD, Asthma and Cystic fibrosis. COPD is a common disease worldwide. Worldwide prevalence of COPD ranges from 4–6%. Spirometry can be helpful in determining the effects of position on ventilator functions. It is the best method for detecting borderline to mild airway obstruction, which occurs early without the appearance of any symptoms or signs. FEV1 is the most important spirometry measure for the assessment of airflow obstruction. Many researchers have reported significant changes in pulmonary function with positioning. Reductions of 12% for forced vital capacity and 15% for force expiratory volume in one second have been observed in normal individuals between the different body positions of sitting and slumped half lying. The aim of the study was to determine the Effect of different positions on FVC and FEV1 measurements in obstructive pulmonary disease patients. The objective of this study was to investigate changes in pulmonary function values of obstructive pulmonary disease patients with change in position.30 samples were selected according to convenient sampling. Outcome measures were FEV1 and FVC which were calculated in different positions and the result was obtained for comparing the values of   FVC and FEV1 in all the test positions. On application of ANOVA test the following values were obtained. For FVC the f value obtained is 4.187 and p value obtained is 0.003 which is statically significant. For FEV1 the f value obtained is 6.343 and p value obtained is 0.006 which is statically significant. There is an effect of various body positions on FVC and FEV1 in patients with obstructive pulmonary disease.
Resources For Scientific And Technical Information For Designing Regulatory Submissions
Authors: M. Mahesh  , K. Vandana  , K. Nagasree  , K. Shravankumar
Published: January 2025

The pace of scientific progress over the past several decades within the biological, drug development, and the digital realm has been remarkable. The'omics revolution has enabled a better understanding of the biological basis of disease, unlocking the possibility of new products such as gene and cell therapies which offer novel patient centric solutions. Innovative approaches to clinical trial designs promise greater efficiency, and in recent years, scientific collaborations, and consortia have been developing novel approaches to leverage new sources of evidence such as real-world data, patient experience data, and biomarker data. Alongside this there have been great strides in digital innovation. Cloud computing has become mainstream and the internet of things and block chain technology have become a reality. These examples of transformation stand in sharp contrast to the current inefficient approach for regulatory submission, review, and approval of medicinal products. This process has not fundamentally changed since the beginning of medicine regulation in the late 1960s. Fortunately, progressive initiatives are emerging that will enrich and streamline regulatory decision making and deliver patient centric therapies, if they are successful in transforming the current transactional construct and harnessing scientific and technological advances. Such a radical transformation will not be simple for both regulatory authorities and company sponsors, nor will progress be linear. We examine the shortcomings of the current system with its entrenched and variable business processes, offer examples of progress as catalysts for change, and make the case for a new cloud based model. To optimize navigation toward this reality we identify implications and regulatory design questions which must be addressed. We conclude that a new model is possible and is slowly emerging through cumulative change initiatives that question, challenge, and redesign best practices, roles, and responsibilities, and that this must be combined with adaptation of behaviors and acquisition of new skills.
Formulation and Evaluation of Naproxen Sodium 220 Mg Modified Release Tablet Using Novel Technology
Authors: Manikandan G  , Mohammed Omar
Published: January 2025

Development of an experimental design (DOE) aimed at enhancing the modified release formulation of Naproxen Sodium 220 mg through innovative technology. This experimental approach focuses on improving the assay of Naproxen Sodium release tablets by incorporating DisintegrantsValidation of this method will encompass the processes of raw material dispensing, sifting, dry mixing, binder preparation, wet mixing, drying, milling, lubrication, compression. This study illustrates that the solid dispersion technique can significantly enhance the dissolution rate of Naproxen. The results are consistent with numerous other investigations into solid dispersion methods, indicating that this strategy serves as a viable option for pharmaceutical companies seeking to prolong the life cycle of products that exhibit poor solubility. A comparative analysis of the dissolution profiles was performed across various media, both with and without surfactants.
The findings clearly demonstrate that an increase in the concentration of Disintegrants does not lead to interactions with the drug when combined with other excipients, thereby facilitating sustained drug delivery over prolonged periods. The improved formulation, developed through factorial design, can be administered as a single daily dose. The experimental design lays the groundwork for further optimization. In this investigation, Trial #3 emerged as the formulation that most effectively satisfies all criteria for an optimal formulation
Therapeutic advances in understanding, diagnosis and treatment of progressive multiple sclerosis
Authors: A Dhanush Kumar  , Nandini Penchala  , Pakala Akhila Reddy  , Shaik Parveen
Published: January 2025

Progressive multiple sclerosis (PMS) is a debilitating neurodegenerative disorder within the broader category of multiple sclerosis (MS) that significantly impacts quality of life due to continuous neuroinflammation and gradual neuronal loss. Unlike relapsing-remitting MS, PMS exhibits minimal acute inflammatory activity and is instead characterized by a steady progression of neurological decline. Recent therapeutic advancements have focused on addressing both the neurodegenerative and immune-mediated components of PMS, with limited success in disease modification. This review explores the pathophysiology, diagnostic advances, therapeutic developments, and emerging research directions in PMS. The pathophysiology section highlights key mechanisms, including oxidative stress, mitochondrial dysfunction, and CNS compartmentalized inflammation, which contribute to progressive axonal and neuronal damage. Diagnostic improvements encompass advanced imaging modalities, such as high-resolution MRI and novel biomarkers like neurofilament light chain (NfL), which enable earlier and more accurate disease monitoring. The review also discusses current disease-modifying therapies (DMTs) and experimental treatments, including monoclonal antibodies, GM-CSF antagonists, and IL-2 receptor inhibitors, focusing on their potential to attenuate disease progression. Additionally, symptomatic management approaches and the role of neurostimulatory techniques in enhancing patient quality of life are examined. Future directions suggest that biomarkers for precision medicine, alongside advancements in cell-based therapies and gene-editing technologies, could provide targeted and individualized treatments for PMS. This review synthesizes current knowledge on PMS and emphasizes the need for continued innovation to effectively manage and ultimately mitigate disease progression.
„Valóknak tartott fontos események” – Vaszary Kolos (1832–1915) történelemtankönyvei
Authors: Jakab Péter
Published: January 2025

Vaszary Kolos esztergomi érsek, bíboros neve az egyháztörténeti munkákban általában az első Wekerle Sándor-kormány egyházpolitikai intézkedéseinek ellenzőjeként jelenik meg. Kevésbé közismert, hogy a magyar egyház fejévé válása (1891) előtt számos helyen (Komárom, Pápa, Esztergom, Győr, Pannonhalma) történelmet, földrajzot a bencések között elsőként oklevél birtokában tanító szerzetes több tankönyvet is írt, érdeklődésének egyik fókuszpontja a magyar középkor volt. Tanította Concha Győzőt, de Baross Gábort és az érseki székben közvetlen utódát, Csernoch Jánost is. Vaszary neve a korszak pedagógiájával, illetve a történelem tantárgytörténetével foglalkozó művek döntő többségéből hiányzik. Az előadás a tankönyvszerző Vaszary jelentősége mellett foglal állást, elsődleges forrásként műveit megvizsgálva. A későbbi bíborosnak ugyanis szerepe volt az önkényuralom időszakában Horváth Mihály műveinek népszerűsítésében, fiatal pedagógusként már történelmi füzetsorozatot (Ifjúsági Plutarch) indított, s önképzőköröket szervezett. Vaszary a korszakban korántsem magától értetődő módon felismerte Luxemburgi Zsigmond uralmának jelentőségét, de figyelme, érdeklődése kiterjedt a hadtörténetre és a 19. századi reformországgyűlésekre is. Két fő alkotásának az 1863-banmegjelentetett Világtörténelem, s az 1865-ben kiadott Magyarország története tekinthető. Térképekkel ellátott, az egyes területek, birodalmak „földrajzi átnézetével” kezdődő fejezetei alapos forrásismerettel és didaktikai tudatossággal jellemezhetők, amelyek hazai történelemtanításunk meghatározó elemei mind a mai napig.
Persepsi Masyarakat Indonesia Terhadap Kenaikan Harga Emas Sebagai Instrumen Investasi Jangka Panjang: Sebuah Tinjauan Literatur
Authors: Siagian Riza Rasyid Al-Aufa
Published: January 2025

Penelitian ini bertujuan untuk mengkaji persepsi masyarakat Indonesia terhadap kenaikan harga emas sebagai instrumen investasi jangka panjang. Dengan menggunakan pendekatan tinjauan literatur yang didukung oleh data empiris, penelitian ini mengidentifikasi faktor-faktor makroekonomi utama yang memengaruhi keputusan investasi emas, termasuk inflasi, suku bunga, nilai tukar mata uang, dan literasi keuangan. Temuan penelitian menunjukkan bahwa kenaikan inflasi dan depresiasi nilai tukar mendorong peningkatan permintaan emas, sementara penurunan suku bunga memicu peralihan dari instrumen berbasis bunga tradisional ke investasi emas. Selain itu, perkembangan teknologi dalam platform emas digital telah memperluas akses bagi generasi muda, mencerminkan perubahan preferensi investasi. Namun, tantangan seperti volatilitas harga emas global dan rendahnya literasi keuangan menghambat optimalisasi investasi emas secara penuh. Penelitian ini berkontribusi pada pemahaman yang lebih komprehensif mengenai potensi dan tantangan investasi emas di Indonesia.
Sharia-Based Risk Management: A Literature Review on Its Impacts and Potential in Supporting Sustainable Economy
Authors: Siagian Riza Rasyid Al-Aufa , Kamilah
Published: January 2025

This study explores the concept of Sharia-based risk management and its potential role in fostering sustainable economic development. By synthesizing recent literature, the research identifies core principles, impacts, and challenges associated with the application of Sharia-compliant risk management practices in various sectors, including finance, trade, and industry. The findings highlight the alignment of Sharia principles with sustainability objectives, offering innovative insights into risk mitigation strategies that promote ethical and equitable economic growth. This paper also proposes a framework for integrating Sharia-based risk management into global sustainability practices.
Dans l'œil de l'Obvia - Comment intégrer l’IA de manière responsable au sein de l’administration publique?
Authors:   Observatoire international sur les impacts sociétaux de l'intelligence artificielle et du numérique
Published: January 2025

Le Québec s’est doté d’une Stratégie d’intégration de l’IA dans l’administration publique en 2021. Son objectif consiste à soutenir l’utilisation de l’IA par les organismes publics et à baliser son usage pour améliorer la qualité, l’efficience et l’équité des services offerts aux citoyens. La stratégie est en cours de déploiement. Les attentes sont élevées envers l’IA : réduire la taille de l’État, améliorer la productivité des fonctionnaires, valoriser leur travail (en les délestant de tâches à faible valeur ajoutée) et surtout, améliorer les services à la population. La science a creusé la question de l’intégration de l’IA dans les administrations publiques et peut apporter des enseignements précieux aux acteurs qui auront la responsabilité de mettre en place ces nouvelles technologies au sein de l’appareil de l’État.
Systematic Comparison, Evaluation and Identification of Robust Model to Forecast the Closing Price of S&P 500 Financial Sector through Classical and AI-Based Approaches
Authors: Tsokos Chris P , Iluppangama Malinda , Abeywardana Dilmi
Published: January 2025

S&P 500 is the largest and state-of-the-art stock market index in North America, which attracted a wide range of audience. The primary objective of this study is to compare the widely used four stock forecasting approaches: Long Term- Short Term Memory (LSTM), Gated Recurrent Unit, (GRU), Convolutional Neural Network, (CNN) and traditional forecasting approach: Auto- Regressive Integrated Moving Average (ARIMA) to identify the best and more robust forecasting model for daily and weekly closing price on the S&P 500 financial sector. Thus, we developed and compared the performance and quality of these AIbased approaches with baseline traditional ARIMA model using well- defined two statistical metrics, Root Mean Square Error (RMSE) and Mean Absolute Error (MAE) as the evaluation criterion. In the scope of our study, we have found that the LSTM outperforms (with more than 15% improvement in RMSE and with more than 30% improvement in MAE compared to ARIMA) 2 out of 3 train/test data splits compared to other proposed deep learning approaches including GRU and traditional ARIMA models with respect to two widely used RMSE and MAE evaluation metrics for daily closing price forecasting in the S&P 500 Financial Sector. Additionally, in the weekly closing price forecasting models, the traditional ARIMA model outperforms all deep learning models on 2 out of 3 train/test data splits with respect to the statistical metric RMSE.
Decarbonization of Indian Banking: Challenges & Pathways Forward
Authors: Anjanappa Janardhana
Published: January 2025

This study examines the challenges for decarbonizing the Indian banking sector, a critical step in India's commitment to the Paris Agreement. The objective is to assess the current status of decarbonization, identify key challenges, and propose strategic solutions to facilitate sustainable banking practices. In this context, the research employs a qualitative approach, analyzing secondary data from literature, policy documents, and industry reports. The novelty of the research lies in its comprehensive assessment of the multifaceted challenges financial, regulatory, technological, and socio-cultural specific to the Indian context. It provides a nuanced understanding of the sector's progress and the barriers it faces, which is crucial for policymakers and banking institutions.

The findings reveal a mixed landscape of decarbonization efforts, with some banks successfully adopted sustainable banking practices, while others struggle with scaling and operational constraints. Key findings indicate that while some Indian banks have made strides in adopting green practics, the sector as a whole is hindered by high costs of green technologies, regulatory uncertainty, outdated technological systems, and a culture resistant to change. The study highlights the need for clear policies, investment in technology upgradation, and a cultural shift towards sustainability within the banking sector.
The Structural Model for Predicting Addiction Potential in Adolescent Boys Based on Sensation Seeking with the Mediation of Resilience
Authors: Akbari Azar , Sharifi Nastern , Pasha Sharifi Hassan , Mirhashmi Malek
Published: January 2025

Objective: The objective of the present study was to predict addiction potential in adolescent boys based on sensation seeking, with the mediation of resilience.

Methods and Materials: The research method was descriptive and correlational. The statistical population included all 12-year-old male students from public schools in Tehran during the first and second semesters of the 2018-2019 academic year. A total of 300 students were selected through multi-stage random sampling. The research tools included the Sensation Seeking Scale, the Connor-Davidson Resilience Scale, and the Adolescent Addiction Potential Scale. The data were analyzed using structural equation modeling and AMOS software.

Findings: The results showed that sensation seeking (β = 0.501, P = 0.001) positively and significantly predicted addiction potential in adolescents, while resilience (β = -0.246, P = 0.001) negatively and significantly predicted addiction potential in adolescents. Sensation seeking, through the mediation of resilience, predicted addiction potential in adolescents (β = 0.074, P = 0.010).

Conclusion: Sensation seeking, through the mediation of resilience, predicted addiction potential in adolescent boys. It is recommended that specialists implement educational and therapeutic programs aimed at enhancing resilience for sensation-seeking adolescents and youth in educational and university settings.
The Effectiveness of an Integrative Coaching Psychology Intervention Program on the Well-Being of Parent with Preadolescent with Symptoms of Externalizing Disorders
Authors: Pahlavnejad Amir Mohammad , Ghanbaripanah Afsaneh , Nourmohammadi Farahnaz , Poushaneh Kambiz
Published: January 2025

Objective: The objective of this study was to evaluate the effectiveness of an integrative coaching psychology intervention program on the well-being of parent with preadolescent with symptoms of externalizing disorders.

Methods and Materials: This quasi-experimental study utilized a mixed between-within subjects design, including one experimental group and one control group, with random assignment and pre-test, post-test, and two-month follow-up assessments. The participants were parents of preadolescent diagnosed with symptoms of externalizing disorders, selected through purposive sampling. The intervention involved a 10-week integrative coaching psychology program. Data were collected using the PERMA well-being questionnaire and the Achenbach Child Behavior Checklist (CBCL). Data analysis included descriptive statistics and two-way repeated measures ANOVA to evaluate the impact of the intervention.

Findings: The results indicated a significant improvement in the well-being scores of the experimental group from pre-test to post-test and follow-up stages (p < .01), with no significant difference between post-test and follow-up scores, indicating the stability of the intervention's effects. The experimental group also showed significantly lower scores in negative emotions and loneliness, and higher scores in overall happiness, health, and well-being compared to the control group. The control group did not exhibit significant changes across the stages.

Conclusion: The integrative coaching psychology intervention program was effective in enhancing the well-being of parent with preadolescent with symptoms of externalizing disorders. The program led to significant improvements in positive emotions, engagement, relationships, meaning, and accomplishment, while reducing negative emotions and loneliness.
Spiritual Health Reducers in Adolescents
Authors: Rahimzadeh Maryam , Safara Maryam , Aghayousfi Alireza
Published: January 2025

Objective: The study aimed to explore the barriers to spiritual health in adolescents.

Methods and Materials: This research employed a qualitative content analysis approach, utilizing semi-structured interviews to gather data. The study sample included 12 adolescents (born between 2003 and 2009), 8 parents, and 7 experts in spiritual health and adolescent psychology, all residing in Tehran. Data were collected over 2022–2023 through in-depth interviews, coded, and categorized into thematic areas. Participants were selected using purposive sampling until saturation was reached. The data analysis followed the Graneheim and Lundman (2004) content analysis methodology.

Findings: The study identified multiple barriers to adolescent spiritual health, categorized into environmental, belief-based, cognitive, behavioral, educational, and psychological-emotional themes. Key factors included urban distractions, social media, doubts about religious beliefs, religious laxity, instrumental use of religion, emotional instability, perfectionism, and lack of educational support. Adolescents were found to grapple with existential questions, self-identity issues, and a lack of understanding or support from their environment, leading to mental and spiritual conflicts.

Conclusion: Spiritual health in adolescents is deeply influenced by family, education, and environmental factors. Despite the innate potential for spiritual growth, external barriers such as excessive technological exposure, parental pressure, and societal distractions can hinder spiritual development. Policymakers and educators should focus on reducing these barriers by fostering supportive environments and integrating spiritual health into adolescent development programs.
Strategi Pertumbuhan Ekonomi Berkelanjutan Melalui Penerapan Environmental, Social, and Governance (ESG) pada Kewirausahaan
Authors: Ayu Winda Amalia  , Soeratin Harry Z
Published: January 2025

Isu lingkungan dan sosial telah meningkat dan menjadi perhatian global hingga menyebabkan intensi perekonomian saat ini berfokus pada pembangunan yang berkelanjutan. Seiring meningkatkan tekanan global terhadap perubahan iklim dan kerusakan lingkungan, wirausahawan memiliki peran penting dalam menemukan, menciptakan, berinovasi, dan mengadopsi praktik-praktik ramah lingkungan. Penerapan ESG dalam kewirausahaan merupakan langkah strategis dalam mendorong pembangunan secara berkelanjutan. Tidak hanya bagi perusahaan besar, penerapan ESG dapat mendorong UMKM sebagai tulang punggung perekonomian nasional tumbuh menjadi ekonomi yang berkelanjutan. Tujuan dari penulisan ini adalah untuk mengetahui peran ESG pada kewirausahaan sebagai strategi pertumbuhan ekonomi yang berkelanjutan. Penulisan ini menggunakan literature review sebagai metode untuk mendalami topik yang dikaji secara kritis. Dari penulisan ini diperoleh bahwa komitmen terhadap ESG secara signifikan mempengaruhi reputasi suatu bisnis dan kesuksesan usaha  yang berkelanjutan.
Immunotherapy for Alzheimer's disease: advances in adaptive immunity
Authors: Zhi Ting-Ting
Published: January 2025

Alzheimer's disease (AD) is a neurodegenerative disorder primarily associated with dementia. Emerging evidence highlights the significant role of the immune system in AD pathogenesis, positioning immunotherapy as a promising area of research. This article summarizes the role of adaptive immunity in AD and reviews current treatment strategies. A total of 74 out of 120 relevant articles were analyzed using keywords such as "Alzheimer's disease" and "immunity." Findings suggest that adaptive immunity may facilitate the clearance of amyloid-beta (Aβ) and tau proteins. Monoclonal antibodies and other immunotherapeutic approaches targeting Aβ and tau have progressed from preclinical studies to clinical trials, demonstrating favorable safety and tolerability profiles, albeit without achieving substantial clinical efficacy. In conclusion, while adaptive immunity plays a critical role in AD pathogenesis and treatment, further investigation into immune tolerance and individual variability is essential to enhance therapeutic outcomes.
The Flip Chart to enhance EFL learners’ vocabulary
Authors: Velastegui Campoverde Judith Michell , Logacho Quishpe Israel Steven , Venegas Álvarez Gina Silvana
Published: January 2025

This research aimed to analyze the effectiveness of the flipchart to improve the vocabulary of English as a foreign language for students between 10 and 12 years old in the El Carmen La FAE neighborhood. The problem of this research was the monotonous use of the blackboard, generating low performance in the student's acquisition of vocabulary in the English language. The researcher used a mixed approach and a quasi-experimental method. The population was students aged 10-12 years from the El Carmen La FAE neighborhood, with level A1 in English, at the 2024-2025 academic level. Participants were selected through convenience sampling, aimed at accessible people in the area, consisting of 15 students. Multiple choice questions helped to collect data for pre test and post test. The research results demonstrated that the flip chart combined with the ERCA method proved an effective and dynamic tool for teaching vocabulary. The previously analyzed literature also helped with information for the correct implementation of the teaching resource with the following scores obtained in the pre test without the flip chart at 64% and after with the flip chart in the post test at 97%. Furthermore, the application of the flip chart had a significant improvement of 33.12% and a maximum score of 100%.
Diotima: An Improved Female Paradigm Against Aristophanes’ Thesmophoriazusae
Authors:   Università degli Studi di Milano, Volpi Penelope
Published: January 2025

In Plato’s Symposium, Socrates praises Eros through Diotima, thus introducing a female voice into a quintessentially male institution. In doing so, I argue, he appropriates Agathon’s theory of mimesis as found in Aristophanes’ Thesmophoriazusae. By reporting Diotima’s words, not only does Socrates reply to Agathon’s speech in the Symposium; he also puts forth an improved female paradigm against the backdrop of Aristophanes’ Agathon and, more in general, Thesmophoriazusae. In the appendix, I will consider Christian Poggioni’s solo performance of the Symposium, which emphasises precisely the connection between Plato and Aristophanes. Among other things, this informs his decision to use a theatrical mask only when delivering Diotima’s reported words. In sum, my own reading and Poggioni’s performance seem to complement and reinforce each other.
Alcune osservazioni sugli aspetti di teatralità del Simposio di Platone
Authors:   Università Cattolica del Sacro Cuore di Milano, Zanzottera Lisa
Published: January 2025

Il Simposio di Platone è un testo dalla solida struttura filosofico-retorica che contiene anche importanti escamotage teatrali. Il legame di quest’opera con la scena è, in realtà, evidente: Agatone celebra la sua vittoria alle Grandi Dionisie. Al convito discorre Aristofane. Il Simposio, pur non scritto come canonica drammaturgia teatrale, è stato però più volte messo in scena. Si pensi, in Italia, al lavoro di Carlo Rivolta nato negli anni Novanta, sostenuto da Giovanni Reale, alla mise en espace della Fondazione Collegio San Carlo in collaborazione con Emila Romagna Teatro Fondazione del 2017 e allo spettacolo di Christian Poggioni del 2019. Il lavoro vuole evidenziare gli escamotage teatrali del Simposio e valutare come le performance valorizzino l’opera. Si affronterà anche il problema dell’adattamento drammaturgico e della traduzione: per rappresentare Platone sono necessarie una struttura e una lingua adatte alla scena ma che non impoveriscano i concetti filosofici.
Exploring Parental Perspectives on Factors Influencing Sugar-Sweetened Beverage Consumption in Children Aged 8 to 14
Authors: Hasan Md Rakibul , Rony Samir Kumar Sarker
Published: January 2025

Background: This study explores the increasing consumption of sugar-sweetened beverages (SSBs) among children aged 8 to 14 years from the parental perspective, aiming to identify influencing factors.
Methods: A qualitative phenomenological approach was used, involving in-depth interviews with parents. Thematic analysis was employed to extract insights. The study was conducted in Coventry, West Midlands, UK with a purposive sampling technique to select participants. Data were manually transcribed and analyzed using Braun and Clarke's six-phase framework for thematic analysis.
Results: Four key themes surfaced: (1) parental control over the provision of sugar-sweetened beverages, (2) marketing tactics, (3) shopping and special events, and (4) friend influence. Children's drinking habits are greatly influenced by parental practices, such as rewarding children with SSBs and giving their desires priority. Lower pricing makes SSBs more accessible, and effective marketing—which includes commercials and a variety of product options—encourages usage. Peer pressure and special events also play crucial roles.
Conclusion: The research emphasizes how peer pressure, marketing, special events, and parental conduct all interact in intricate ways to impact children's intake of sugar-sweetened beverages. To address these concerns, it emphasizes the need of focused public health initiatives and policies. The growing trend of SSB intake may be lessened by informing parents about healthier options and the dangers of SSBs, as well as by regulating marketing strategies. Public health benefits greatly from this study, which indicates that to properly address this problem, more professional engagement and development are necessary.
Temporomandibular Disorders and Climacteric Disorders in Argentina: Advances and Challenges for Comprehensive Care
Authors: Samón Mayán Youris , Rodríguez Yanes Ana
Published: January 2025

In 2024, the Stomatognathic System (ES) and Temporomandibular Disorders (TMD) acquired a particular relevance in Argentina due to the demographic, economic and health changes affecting its constantly changing population. The aging population structure and the increase in life expectancy generated direct implications in the prevalence and management of TMDs, especially in women during climacteric and menopause. The socioeconomic context presented contrasts, with growing access to health services thanks to public policies focused on primary health care, although inequalities persisted between urban and rural areas. These inequalities affected the quality of the specialized treatments needed for TMDs, aggravating the situation of vulnerable women due to economic barriers and lack of information.During the climacteric period, hormonal changes had a negative impact on oral and maxillofacial health, exacerbating TMDs, which are more prevalent in women than in men, with a ratio of three to one. Factors such as emotional stress and psychological disorders, intensified by inflation and economic uncertainty, played a crucial role in the etiology of TMDs. The importance of preventive strategies, such as educational campaigns and professional training to identify and treat TMDs early was highlighted. However, the limitations of the public health system and the high costs of specialized treatments restricted their scope. Despite advances in academic training and interdisciplinary approach, the need for more comprehensive public policies that prioritize women's health became evident. Argentina faced the challenge of consolidating an equitable model that would guarantee access to effective treatments, allowing women in climacteric conditions to live with dignity and wellbeing
STUDI ANALISIS IKLIM PADA TAPAK KOMPLEK BALIKPAPAN SPORT dan CONVENTION CENTER
Authors: Mattin Abdul , Annisa Derie , Fraisa Dian , Nur Rachman Fajri
Published: January 2025

.Iklim dan pergerakan matahari memiliki pengaruh tinggi pada sebuah tapak bangunan. Gedung Balikpapan Sport & Convention Center merupakan landmark kota Balikpapan. Penelitian ini bertujuan untuk mengidentifikasi kondisi pergerakan matahari pada tapak dalam periode satu tahun dan bagaimana dampaknya terhadap lingkungan sekitarnya. Penelitian ini menggunakan pendekatan paradigma kualitatif dengan alat analisis perangkat lunak sunearthtool, pada tapak Gedung Balikpapan Sport & Convention Center. Penelitian ini menyimpulkan bahwa lokasi tapak Gedung Balikpapan Sport & Convention Center berada pada jalur peredaran matahari yang puncaknya pada periode pada bulan Jan – Apr terletak pada 250-110 derajat. Pada periode tersebut setiap harinya sinar matahari bersinar penuh dalam 12 jam. Pada simulasi ditemukan waktu paling tinggi paparannya terhadap sisi bangunan adalah pada pukul 09;00 pagi dan 15;00 sore. Bentuk Gedung yang berbentuk lingkaran/tabung, mengakibatkan paparan maksimal matahari rata pada kedua sisi bangunan.
MENGUNGKAP BANJIR DI DAERAH POSINDO BALIKPAPAN
Authors: Silfani A Fitri , Ardiyansah Ardiyansah
Published: January 2025

Banjir adalah persoalan serius dan sering terjadi di sekitar Posindo Balikpapan. Faktor-faktor seperti curah hujan yang tinggi, penggundulan hutan yang tidak terkendali, perubahan penggunaan lahan dan akumulasi limbah berkontribusi terhadap banjir yang berbahaya secara sosial, lingkungan dan ekonomi. Dampak banjir meliputi kerugian ekonomi, kerusakan lingkungan, dan risiko kesehatan masyarakat. Artikel ini mengeksplorasi upaya untuk mengatasi banjir, termasuk memperbaiki drainase, memulihkan hutan dan vegetasi, mendidik masyarakat, dan menegakkan peraturan. Melalui langkah-langkah tersebut diharapkan dapat mengurangi risiko dan dampak banjir di Posindo Balikpapan dan sekitarnya. Kolaborasi antara pemerintah, masyarakat, dan instansi terkait penting untuk mengatasi tantangan ini guna menjaga kelestarian lingkungan dan kesejahteraan masyarakat
ZERO ENERGY BUILDING (ZEB) LITERATUR REVIU BERBASIS PERKEMBANGAN IMPLEMENTASINYA
Authors: Mattin Abdul
Published: January 2025

EISA 2007 mengesahkan Inisiatif Bangunan Komersial Energi Nol Bersih untuk mendukung tujuan energi nol bersih untuk semua bangunan komersial baru pada tahun 2030. Penelitian ini bertujuan untuk mengungkap perkembangan konsep zero energi building dalam artikel publikasi akademik yang terlebih dahulu terbit, untuk mengetahui sumbangsih peneliti dalam menurunkan emisi CO2 secara global pada bangunan-bangunan didunia. Penelitian ini menemukan pada publikasi terdahulu bahwa Konsep Zero Energy Building (ZEB) adanya penggunaan rasio energi bersih (NER) sebagai faktor untuk membantu desain bangunan dengan perspektif siklus hidup, opsi parameter selubung bangunan, unit pemulihan panas, dan sistem pemanas/pendingin serta berbagai ukuran tata surya termal dan fotovoltaik adanya pengembangan alat pendukung keputusan untuk memungkinkan desainer menilai kenyamanan termal dan kinerja energi dari alternatif desain awal dengan cepat dan fleksibel. Perkembangan teknologi lainnya di masing-masing bahan baku penting yang dapat mendukung integrasi NZEB/PEB. perbedaan antara energi dan energi primer, dan antara sumber energi dan pembawa energi. Penggunaan faktor metrik dan faktor konversi energi primer dihasilkan dari sumber energi terbarukan di lokasi, terdekat atau jauh.
I Contratti di fiume tra Nature Restoration Law e Green Infrastructure
Authors: Coppola Emanuela
Published: January 2025

Il Contratto di fiume è uno strumento in cui poter sperimentare le istanze più moderne della pianificazione: approccio strategico, partecipazione, visioning, progetto di paesaggio. L’approccio metodologico utilizzato per il “Progetto verso il Contratto di fiume del Vulture” è sistemico e finalizzato alla valorizzazione di un ambito territoriale complesso caratterizzato da elevati valori paesaggistici.
Performance Measurement Framework Using Human Resource Analytics for Private Higher Education Institutions
Authors:   Notre Dame of Dadiangas University, Robles Denise Meryl
Published: January 2025

The purpose of this research is to provide a performance measurement framework with key performance indicators (KPIs) practiced by private higher education institutions (HEIs) in terms of instruction, research, and community extension which used human resource analytics (HRA) for objectively measuring academic performance. This is to provide an analytical scientific approach using Analytical Hierarchy Process (AHP) to measure the performance of academic staff of private HEIs in South Cotabato, Sarangani, and General Santos City (SOCSARGEN). This research used the sequential qualitative-quantitative research design methodology which conducted two (2) sessions of focus group discussions (FGD) from seven (7) participating schools with fifteen (15) participants and utilization of the developed performance measurement tool to three (3) private HEIs as basis to develop the performance measurement framework. The selection of participants consists of academic administrators and staff using purposive sampling. This study uses thematic analysis, AHP and ranking to obtain objective and reliable insights on performance evaluation relevant for human resource analytics. Based on results, in terms of instruction, sub-KPIs include work ethics, personality and values, teaching competence and performance, learning atmosphere, qualification, involvement and productivity. In terms of research, sub-KPIs include attendance and presentation, citations and publications, journal memberships and research involvement. In terms of community extension, sub-KPIs include participation and involvement in extension works and external linkages. This research also developed a general performance measurement framework which consists of setting goals and objectives, indicators, evaluation, analysis, reporting and review.
Լիբանանի Հայօճախը. Գիրք Ա., Համարկումին Խաչուղիները (1920-2005)
Authors: Dakessian Antranik
Published: January 2025

The volume aims to document the experiences of Lebanese Armenians over the last century, focusing on their integration into the Armenian community. It traces the journey from displacement to settlement and then to assimilation within the Armenian community, summarizing the period from 1920 to 2005. Special attention is given to the Armenian community during the period from 1990 to 2005, capturing the sentiments, understandings, and mentality of that time, while excluding the mentality that emerged after 2005.