bluuebunny/crossref_metadata_2025 huggingface dataset:
A CASE REPORT: EXPLORING STARGARDT DISEASE - CLINICAL FEATURES AND GENETIC INSIGHTS
Authors:   Ophtalmology A, Hopital Des Specialites Rabat, University Mohamed V., a Meryemsefrioui , Lazaar Hamza ,   Ophtalmology A, Hopital Des Specialites Rabat, University Mohamed V., a Hamidisalma ,   Ophtalmology A, Hopital Des Specialites Rabat, University Mohamed V., b Saadbenchekroun ,   Ophtalmology A, Hopital Des Specialites Rabat, University Mohamed V., c Abdellahamazouzi ,   Ophtalmology A, Hopital Des Specialites Rabat, University Mohamed V., Facherkaoui Lallaoua ,   Ophtalmology A, Hopital Des Specialites Rabat, University Mohamed V.
Published: March 2024

Stargardt disease (SD) stands as a prominent inherited macular dystrophy affecting both adults and children, characterized by bilateral and symmetrical maculopathy with autosomal recessive transmission linked to the ABCA4 gene. We aim to present a comprehensive exploration of SD, delving into its clinical manifestations, genetic intricacies, and potential therapeutic interventions. This case report highlights a 46-year-old north African male with late-onset STGD with gradual bilateral vision decline, central macular atrophy, and yellow deposits in the perimacular region. the spectrum of SD is diverse, ranging from childhood onset to adult manifestation, often mimicking age-related maculopathy. Stargardt diseases genetic landscape is intricately governed by the ABCA4 gene, marked by over 900 variants across its 50 exons. This genetic diversity extends to dominant genes such as STGD4, ELOVL4, and PRPH2, contributing to a spectrum of retinal disorders. Therapeutic approaches for Stargardt disease involve drugs targeting the visual cycle, a modified vitamin A, and ongoing gene replacement and stem cell therapy trials This comprehensive review amalgamates clinical observations, genetic considerations, and emerging therapeutic avenues.
WATER CRISIS ESCALATION: GLOBAL CHALLENGES AND URGENT IMPERATIVES-REVIEW
Authors:   Lecturer in Chemistry, S.V.R.M College, Nagaram., Babu Racheeti Prasanna
Published: March 2024

The world is facing an escalating water crisis, posing significant challenges and urgent imperatives for global sustainability. This review delves into the multifaceted dimensions of this crisis, examining its origins, current status, and potential future trajectories. We analyze the complex interplay of factors driving water scarcity, including population growth, climate change, urbanization, pollution, and unsustainable resource management practices. Moreover, we explore the profound socio-economic and environmental impacts of water scarcity on human health, agriculture, industry, and ecosystems, highlighting its disproportionate effects on vulnerable communities. By synthesizing insights from interdisciplinary research, policy documents, and expert perspectives, we identify key strategies and interventions aimed at addressing the water crisis. These include enhancing water governance frameworks, investing in water infrastructure and technology, promoting water conservation and efficiency measures, and fostering international cooperation and partnerships. Furthermore, we underscore the need for innovative approaches, such as nature-based solutions and integrated water resources management, to build resilience and adaptability in the face of uncertain climatic and demographic trends. Urgent action is required at local, national, and global levels to mitigate the impacts of the water crisis, safeguard water security, and ensure equitable access to this vital resource for current and future generations. This review provides a comprehensive synthesis of knowledge and insights to inform policy formulation, planning, and decision-making processes aimed at addressing the critical challenges posed by the escalating water crisis on a global scale.
AYURVEDAS INSIGHT INTO MIGRAINE: A COMPREHENSIVE GUIDE TO UNDERSTANDING AND MANAGING THIS DEBILITATING CONDITION
Authors:   Asst. Professor, Rachana Sharir, Late B.V. Kale &ManjaraAyurved College & Hospital, Latur., Anand Pawar Sumol , Dinkar Deshpande Uma ,   PG Scholar, Rachana Sharir, Late B.V. Kale &ManjaraAyurved College & Hospital, Latur.
Published: March 2024

Explore the ancient wisdom of Ayurveda through the lens of migraine management in this comprehensive guide. Delve into the root causes of migraines according to Ayurvedic principles, understanding the doshas and their impact on headaches. Discover personalized approaches to prevention and relief, incorporating lifestyle adjustments, dietary recommendations, and herbal remedies. Unearth the significance of balancing energy channels, or nadis, and the role of Ayurvedic therapies such as Shirodhara. From holistic perspectives to practical tips, this article provides a holistic view of migraines, inviting readers to embrace Ayurvedic insights for enhanced well-being and a profound understanding of this challenging condition.
A COMPREHENSIVE REVIEW OF LITERATURE ON PRAMEHA
Authors:   Asst. Professor, Rachana Sharir, Late B.V. Kale &Manjara Ayurved College & Hospital, Latur., Anand Pawar Sumol , Rathod Neha ,   PG Scholar, Rachana Sharir, Late B.V. Kale &Manjara Ayurved College & Hospital, Latur.
Published: March 2024

This abstract examines the literature on Prameha, a word that encompasses several metabolic problems, in order to provide light on Ayurvedas unique insights regarding pancreas health. The review delves into historical Ayurvedic literature, examining their viewpoints on preserving pancreatic health and averting issues associated with Prameha. The abstract attempts to offer light on holistic approaches to pancreas health within the Ayurvedic framework by fusing ancient wisdom with new scientific findings. A fuller comprehension of Ayurvedas contributions to contemporary viewpoints on metabolic health comes from this investigation, with possible implications for integrative healthcare practices and preventive measures.
VARICELLA-ZOSTER VIRUS INFECTION IN A PATIENT 12 DAYS POST RITUXIMAB: UNUSUAL CO-PRESENTATION OF SHINGLES AND CHICKENPOX
Authors:   Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University Mohamed V, Rabat, Morocco., Fliti Amani , Elomari Alaoui Meryem ,   Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University Mohamed V, Rabat, Morocco., Meziane Mariame ,   Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University Mohamed V, Rabat, Morocco., Ismaili Nadia ,   Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University Mohamed V, Rabat, Morocco., Benzekri Laila ,   Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University Mohamed V, Rabat, Morocco., Senouci Karima ,   Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University Mohamed V, Rabat, Morocco.
Published: March 2024

Rituximab, an anti CD20 monoclonal antibody, is used in the management of lymphoproliferative and autoimmune conditions such as pemphigus. As an immunosuppressor, it exposes patients to an increased risk of infection. Two cases of varicella-zoster virus infection post Rituximab were been reported in literature. The coexistence of chickenpox (primary infection) and shingles (reactivation of latent infection) in the same patient has never been reported in the literature, especially after rituximab treatment. Herein we present the first case of association of these 2 manifestations in a patient 12 days after rituximab therapy for pemphigus.
PUBLIC ADMINISTRATION: A CONCEPTUAL ANALYSIS
Authors:   Balimela College of Science & Technology and Odisha State Open University, Government Model Degree College Study Centre, Malkangiri, Odisha, India., Kumar Dash Kishor
Published: March 2024

Background/Objectives: Administration is a term that explains the ways of getting work done by others for the benefit of a certain entity. Public administration engages public servants to make better rule and regulations by understanding their interests that are able to make the life of citizens easier. Material and methods: Secondary qualitative method will be pursued in this research to acquire significant analysis. Significance of the study: However, challenges are present in the job role for which effective steps by the government need to take. Findings: The result findings symbolize the various knowledge based is on the concepts of public administration and it is explained well in this article, which explains the motive of it managing the local services and managing political influences on sectors. Conclusion: There are the crucial improvements on the growth of different public administration as per critical approach of analysis.
Examining the bonus mechanisms’ role in real earnings management dynamics in an Indonesian manufacturing company
Authors: Akbar Taufiq , Ridarmelli  , Wijayanti Inung , Pramesworo Septo , Esti Riwayati Hedwigis
Published: March 2024

Real Earnings Management (REM) and financial success may have different relationships depending on how managers act. Bonus mechanisms are a significant factor that influences management behavior. The study seeks to examine the impact of bonus systems on the correlation between financial performance and REM practices in manufacturing companies in Indonesia. Moderated Regression Analysis (MRA) is employed to evaluate the influence of bonus mechanisms in moderating the association of financial performance on REM. The technique of purposive sampling was used to pick the sample. The study utilized data from manufacturing firms listed on the Indonesian Stock Exchange from 2017 to 2021, including a total of 400 observed data points. The research findings demonstrate that sales growth is the sole factor that significantly influences REM in manufacturing organizations, as indicated by a p-value below 10%. Other financial performance factors, on the other hand, with p-values for each variable above 10%, have not been shown to have a significant impact on REM. These factors include ROA, leverage, operating cash flow, and cash. The findings also demonstrate that, with a p-value for each variable above 10%, the bonus mechanism is a variable that modifies the effect of all financial performance variables on REM.
Assessing groundwater quality in Nand Samand catchment, Rajasthan, India: a GIS-based multi indices approach for drinking and irrigation water suitability
Authors: Dimple  , Singh Pradeep Kumar , Kothari Mahesh , Yadav Kamal Kishore , Bhakar Sita Ram , Rajput Jitendra , Anvesha
Published: March 2024

Consistently monitoring groundwater quality (GWQ) is essential to reduce the risk of geochemical contaminants and ensure its suitability for agriculture and human consumption. The current investigation aims to assess groundwater (GW) acceptability in the Nand Samand catchment (NSC), utilizing the water quality index (WQI) and irrigation water quality indices (IWQIs) for domestic and irrigation purposes. To achieve this, GW samples were collected from 95 open wells which were located spatially in the catchment, during the pre-monsoon (PRM) and post-monsoon (POM) seasons of 2019 and 2020, and subsequently analysed for 11 physico-chemical parameters. Electrical conductivity (EC) varied from 1.25 to 6.61 dS/m and 0.58 to 7.42 dS/m during the PRM and POM seasons, respectively. Total dissolved solids of the study area ranged between 180 and 1,180 (27%) to 1,180 and 2,180 (62%) during PRM 1,180 (63%) to 1,180–2,180 (31%) during POM, respectively. The study also computed the ‘sodium adsorption ratio’ (SAR) and ‘residual sodium carbonate’ (RSC) to estimate GW's appropriateness for agriculture, finding it suitable in most locations due to its balanced composition. Based on WQI, varying percentages of samples were classified as ‘good’ and ‘poor’ for potable water quality in both seasons.
Demonstration and performance analysis of on-beach public toilet with a decentralised modified French vertical flow constructed wetland and ex situ electrochlorination integrated treatment system
Authors: Gogoi Jayanta Kumar , Sharma Priya , Talekar Guruprasad , Punyapwar Swapnil , Namdev Keyur , Mutnuri Srikanth
Published: March 2024

This study demonstrated an on-beach public toilet equipped with a sustainable decentralised treatment system in Goa, India. The number of toilet users, freshwater demand, and wastewater (WW) generated per day were documented. The treatment system consisted of a modified French-type vertical flow constructed wetland (MVFCW) and electrochlorinator. The first and second stage MVFCW were an unsaturated and saturated type, respectively. The onsite beach bore well water with a chloride concentration of 8464 ± 415.18 mg/L was electrolysed for 1 h at 40.49 Am−2. Then MVFCW effluent was disinfected by dosing 2412.50 + 278.61 mg/L of chlorine (Cl2) generated at a disinfectant dilution ratio of 1:300 (Cl2:WW). The average daily toilet users, freshwater usage, and WW generated were 96 ± 17.02, 1381.38 ± 380.35 L, and 1407.98 ± 611.8 L, respectively. The integrated treatment system treated 1,400 L/day. The integrated treatment system achieved an average percentage removal of 93.38 ± 0.38% chemical oxygen demand, 79.18 ± 1.55% NO3−, 98.45 ± 0.22% total ammoniacal nitrogen, 93.13 ± 1.19% PO4−3, 87.28 ± 0.2% total suspended solids, 83.09 ± 1.16% total organic carbon, 80.22 ± 0.87% total carbon, 80.05 ± 0.12% inorganic carbon, and 100% coliform. The power consumption cost was 0.17 INR m−3.
Modification of bentonite with black cotton soil and carboxyl methyl cellulose for the enhancement of hydraulic performance of geosynthetic clay liners
Authors: Syed Masoodhu S. , Natarajan N. , Vasudevan M.
Published: March 2024

Geosynthetic clay liners (GCLs) are mostly used as flow barriers in landfills and waste containments due to their low hydraulic conductivity to prevent the leachate from reaching the environment. The self-healing and swell-shrink properties of soft clays (expansive soils) such as bentonite enable them as promising materials for the GCL core layers. However, it is important to modify their physico-chemical properties in order to overcome the functional limitations of GCL under different hydraulic conditions. In the present study, locally available black cotton soil (BCS) is introduced in the presence of an anionic polymer named carboxymethyl cellulose (CMC) as an alternative to bentonite to enhance the hydraulic properties of GCL under different compositions. The modified GCL is prepared by stitching the liner with an optimum percentage of CMC along with various percentages of BCS mixed with bentonite. Hydraulic conductivity tests were performed on the modified GCL using the flexi-wall permeameter. The results suggest that the lowest hydraulic conductivity of 4.58 × 10−10 m/s is obtained when 25% of BCS is blended with bentonite and an optimum 8% CMC and further addition of BCS results in the reduction of the hydraulic conductivity.
ANÁLISE DE INDICADORES PARA CIDADES INTELIGENTES
Authors: Tezza Rafael , Hochsteiner Pedro , Kieling Ana Paula
Published: March 2024

As cidades inteligentes integram tecnologia e agilidade para enfrentar desafios de urbanização e governança, bem como ampliar a qualidade de vida de seus cidadãos. Nesse contexto, faz-se necessário compreender os indicadores que definem o construto de smart cities, considerando o corpo teórico previamente estudado. Esta pesquisa propõe mapear os indicadores formativos de uma cidade inteligente a partir da análise dos artigos publicados sobre a temática. Além disso, pretende apresentar uma agenda de pesquisa no tema, de modo a apoiar futuros estudos neste campo de conhecimento. Como método, adotou-se uma revisão sistemática de literatura com base no Modelo Prisma. A busca considerou artigos em língua inglesa publicados nos últimos dez anos (2013-2022), utilizando como filtros as palavras “smart cities”, “indicators” e “framework”. Baseado na pesquisa, identificou-se 35 artigos, que abrangem uma série de indicadores específicos em suas áreas de atuação, alocados dentro de seis dimensões. Os achados da pesquisa oferecem aportes para pesquisadores do campo e gestores públicos que buscam conhecimentos acerca de cidades inteligentes para aplicação prática.
Synthesis of Polypeptides by Ring-opening Polymerization: A Concise Review
Authors: Badreldin Mostafa , Salas-Ambrosio Pedro , Ayala Marcela , Harrisson Simon , Bonduelle Colin
Published: March 2024

The most economical and efficient route to prepare polypeptides from synthetic
chemistry is through the Ring-opening Polymerization (ROP) of amino acids using Ncarboxyanhydride
(NCA) monomers. Peptide polymers, in contrast to proteins, consist of
repeated amino acid units and are comparatively simpler macromolecules. Despite their
simplicity, these polypeptides offer a unique combination of beneficial traits found in both
synthetic polymers (such as solubility, processability, and rubber elasticity) and natural
proteins (including secondary structure, functionality, and biocompatibility). Nevertheless,
NCA polymerization faces significant challenges, including intricate monomer purification
and the necessity for processing toxic solvents. In this context, this review presents the fundamental
principles of this polymer chemistry, the synthesis of NCA monomers, and the
different methodologies to access polypeptides by ROP. It also explores the most recent advances in this field
of research, with a focus on how new methods enable the use of more reactive initiators and the development of
original processes, including the use of aqueous solvents.
A New Approach in the Early Electrochemical Diagnosis of Hepatitis B Virus Infection using Carbon-based Nanomaterials
Authors: Omidifar Navid , Masoumzadeh Reza , Saghi Seyyed Amirreza , Nikmanesh Ali , Shokripour Mansoureh , Mousavi Seyyed Mojtaba , Nikmanesh Yousef , Gholami Ahmad
Published: March 2024

The importance of early diagnosis of hepatitis B virus infection to treat and follow up this
disease has led to many advances in diagnostic techniques and materials. Conventional diagnostic
tests are not very useful, especially in the early stages of infection; it is therefore suggested that nanomaterials
can enhance them by changing and strengthening their performance for a more accurate
and rapid diagnosis. Electrochemical immunosensors with unique features such as miniaturization,
low cost, specificity and simplicity have become a suitable and vital tool in the rapid diagnosis of
hepatitis B since the patent. Different strategies have been presented, such as graphene oxide and
gold nanorods (GO-GNRs), graphene oxide (GO), copper metal–organic framework/ electrochemically
reduced graphene oxide (Cu-MOF/ErGO) composite, Label-free graphene oxide/
Fe3O4/Prussian Blue (GO/Fe3O4/PB) immunosensor, and graphene oxide–ferrocene-CS/Au (GOFc-
CS/Au) nanoparticle layered electrochemical immunosensor. In this review, we discuss a group
of the most widely used nanostructures, such as graphene and carbon nanotubes, which are used to
develop electrochemical immunosensors for the early diagnosis of the hepatitis B virus.
The Relationship between Statin Intake and Risk of Pancreatic Cancer: A Systematic Review and Meta-Analysis
Authors: Bagheri Hesamaldin , Adeli Omid-Ali , Heidari-Soureshjani Saeid , Azadegan-Dehkordi Zahra , MT Sherwin Catherine
Published: March 2024

Background:

Pancreatic neoplasm is one of the types of cancer with a high incidence
and case-fatality rate.

Objectives:

This study was designed to investigate the relationship between statin intake and the
risk of pancreatic cancer with a systematic review and meta-analysis approach.

Methods:

This study was a systematic review and meta-analysis of studies published before 2023
in Cochrane Library, Web of Science (WOS), PubMed, Google Scholar, ScienceDirect, Scopus,
and Embase databases. The statistical analyses were conducted using Stata software, version 15.
The significance level for this study was set at 0.05.

Results:

This meta-analysis included 32 studies and a total of 5,849,814 participants. The risk ratio
(RR) of pancreatic cancer in comparison to the non-statin receiving group in statin users in total
was equal to 0.75 (95% CI: 0.66-0.86, p-value <0.001), in the cohort studies was obtained to be
0.70 (0.53-0.93), in the randomized clinical trials (RCTs) had a ratio of 0.99 (0.53-1.86), while
studies conducted in American countries had a ratio of 0.69 (0.51-0.93), studies in Asian countries
had a ratio of 0.73 (0.56-0.97), and studies in European countries had a ratio of 0.88 (0.76-1.02).
Furthermore, the study did not detect any signs of publication bias.

Conclusion:

The study findings suggest a potential connection between using statins and a lower
risk of pancreatic cancer. However, it is important to note that controlled clinical trials did not
find a statistically significant association between taking statins and the development of pancreatic
cancer. Therefore, it is advisable to exercise caution when interpreting the results of this study.
Tools for the Calculation of Dissolution Experiments and their Predictive Properties
Authors: Babu S. Ram , T. Sakshi , K. Amardeep
Published: March 2024

Dissolution testing, which establishes the rate and extent of the drug release
from pharmaceutical products intended for oral administration, has been recognized as
a crucial method for drug development and quality control of dosage form. Dissolution
studies also help in establishing the in vitro and in vivo correlative studies, i.e., they can
predict drug release and absorption without performing the study inside living things.
The calculation and interpretation of dissolution data is a very typical task but it has
been made simple by using various software and mathematical tools that easily analyze
and illustrate the drug release data with their interpretation. Currently, most
pharmaceutical companies believe in real-time prediction of dissolution profiles, which
they have done due to their market position and increasing demand. Because of their
competitiveness and rising demand, the majority of pharmaceutical businesses now
support real-time prediction of dissolution profiles. As a result, alternative methods
have been added to acquire a rapid response, such as spectroscopic approaches,
particularly near-infrared spectroscopy (NIRS), which gathers the data based on the
physicochemical features of the dosage form. Advanced multivariate analytic
approaches, such as principal component analysis (PCA), principal component
regression, and classical least squares regression, are widely employed to extract such
data for use in quantitative modelling. There is still a dearth of research into the
combined impact of numerous critical factors and their interactions on dissolution,
despite several studies showing that drug product dissolution profiles can potentially be
predicted from material, formulation, and process information using advanced
mathematical approaches.
Predicting Drug Properties: Computational Strategies for Solubility and Permeability Rates
Authors: Gupta Soni Anshita , Joshi Renjil , Soni Deependra , Deep Kaur Chanchal , Saraf Swarnlata , Kumar Singh Pankaj
Published: March 2024

The oral bioavailability of a medicine can be considerably influenced by its
water solubility, which can also have an impact on how the drug is dispersed through
the body. To decrease the likelihood of failures in the late phases of drug development,
aqueous solubility must be taken into account early in the drug research and
development process. By using computer models to predict solubility, combinatorial
libraries might be screened to identify potentially problematic chemicals and exclude
those with insufficient solubility. In addition to predicting solubility from chemical
structure, the explanation of such models can provide insight into correlations between
structure and solubility and can direct structural improvement to improve solubility
while preserving the effectiveness of the medications under study. Such model
development is a difficult procedure that calls for taking into account a wide range of
variables that may affect how well the model performs in the end. In this article,
various solubility modeling techniques are presented. Despite many studies on model
creation, predicting the solubility of various medications remains difficult. One of the
primary reasons for the poor trustworthiness of many of the suggested models is the
quality of the experimental data that may be used to simulate solubility, which is
becoming more widely acknowledged. Consequently, increased availability of
trustworthy data produced using the same experimental technique is necessary to fully
realize the potential of the established modeling tools.
Deliberations and Considerations of Mesodyn Simulations in Pharmaceuticals
Authors: Yadav Manisha , Mahajan Dhriti , Silakari Om , Sapra Bharti
Published: March 2024

The main aim of this chapter is the detailed analysis of the Mesodyn module
and how it is beneficial in the pharmaceuticals or drug delivery systems. These models
are the generalization of a coarse-grained model in mesoscopic dynamics which is used
for the field-based simulations of complex systems. A set of functional Langevin
equations characterize the system’s behavior. These computer-based simulation tools
have been proven effective for providing information at molecular and mesoscopic
scales and also for overcoming the limitations of wet lab experiments. So, this chapter
will discuss the potential use of Mesodyn simulations in pre-formulations and various
other applications for the rational designing of drug delivery systems after providing a
brief theoretical background.
Data Interpretation and Management Tools for Application in Pharmaceutical Research
Authors: Kaur Arvinder , Kumar Avichal , Manjunath Kavya , Bagur Paramesh Deepa , Murthy Shilpa , Sinha Anjali
Published: March 2024

The information flow in pharmaceutical research before data interpretation
and management was largely manual and simple, with limited application of
technology. Establishing the research objective, designing the study, collecting data,
analyzing data, and interpreting the result were laborious, tedious, and time-consuming
processes. Manually entering and sorting a large amount of data made researchers more
prone to human errors, leading to incorrect and invalid results. The chapter draws on
data mining, data abstracting, and intelligent data analysis to collectively improve the
quality of drug discovery and delivery methods. To develop new drugs and improve
existing treatments, software can be used to analyze large datasets and identify patterns
that help understand how drugs interact with the body. Virtual models of organs and
cells are employed to study the effects of drugs, automate drug testing, and predict
adverse drug reactions. Pharmaceutical management tools, such as pharmacy
management software, electronic prescription software, inventory management
software, and automated dispensing systems, are highly valuable for managing
inventory, tracking patient prescriptions, monitoring drug interactions, maintaining
patient information and history, and providing up-to-date drug information. The main
objective of this chapter is to highlight the various tools and software solutions
available and how they can facilitate the research process to ensure compliance with
relevant regulations and laws regarding human healthcare safety.
Historical Neighborhoods of Edirne
Authors: Erdoğan Nevnihal
Published: March 2024

Developing out of its former role as an old Byzantine fortress, the city
advanced greatly as a Turkish-Muslim city in the Ottoman Empire. The main means of
growth resulted from the establishment of benevolent facilities managed by a charitable
foundation. These charitable foundations, known as Wakfs, had a significant impact on
facilitating the shift towards settled living in both Anatolia and Rumelia. The
advancement was greatly enhanced by the buildings, constructions and enhancement
efforts directed by the successive sultans and prominent state members of varying
levels of authority (second-degree, and third-degree officials of the state). Edirne was
established based on the formula that declares, “there is a mosque in the center of the
neighborhood and the neighborhood is a physical unit as well as a social unit”, and this
type of settlement approach was then implemented in most neighborhoods. The chapter
examines the various original establishments, such as mosques, baths, fountains, and
soup kitchens, as well as the layout of settlements.

Today, the old neighborhoods within each district have amalgamated to create novel
neighborhoods. The fundamental constituents of the old neighborhoods in the nine
regions encompassing public kitchens, mosques, baths, charitable endowments,
thoroughfares, and residences endure in certain neighborhoods to a certain extent,
whereas in other areas, they have become entirely extinct.

In the existing housing settlements, one can see the effect of traditional Anatolian
housing types, Hilani and Megaron, in the plans of houses in the outer districts, and
even in the city center. Plan types with outer sofas could have one, two, three, or four
rooms, while two- and three-roomed examples are more common.
Edirne’s Past and Present Social and Economic Lives
Authors: Erdoğan Nevnihal
Published: March 2024

During those years, when Edirne served as the capital city of the Ottoman
Empire, it was also a leading center for skilled trades and the production of various
artifacts. Edirne was especially known for its wood carving, lacquered bowls and
boxes, floral paintings, book covers, calligraphy and engraving, and tombstone carving.
Very few of these trades have survived to the present.

It is a unique location as a crossroad of civilizations has bequeathed Edirne with a rich
heritage of folk lore and music. Edirne cuisine has its own cooking techniques and
eating habits. Fruits and vegatables are used more in this kitchen.

Festivals in Edirne were organized for the benefit of large crowds of people, rahter than
for a wealthy minority such as it was custom at the European Royal celebrations. We
can easily say that these celebrations have been a part of the daily life of the people.
Concerning festivities were organized on various occasions and the celebrations of the
professional guilds, such as weddings or inaugurations. The city is very rich in terms of
natural beauty. Among these, the most important ones are Inner Palace Grounds, the
cypress grounds, and banks of the Maritsa and Tunca rivers.
TEKNOLOGI ASISTIF SEBAGAI MEDIA PEMBELAJARAN BAHASA INDONESIA SISWA BERKEBUTUHAN KHUSUS
Authors:   Universitas Negeri Malang, Alifian Muhammad Afnani , Zahro Azizatuz ,   Universitas Negeri Malang, Widyartono Didin ,   Universitas Negeri Malang
Published: March 2024

Assistive technology is a special device that consists of a set of technologies tailored to the individual needs of students. This technology can be used by Indonesian language teachers to provide access for students in inclusive classrooms. The implementation of assistive technology is expected to be beneficial in improving students' abilities in learning Indonesian language. Assistive technology can help students with special needs to actively participate in learning, including receiving materials, engaging in the learning process, and evaluation. Based on the literature review, the application of assistive technology in teaching Indonesian language to students with special needs will be effective if done through a systematic process. Starting from preparation, model, framework, implementation, and evaluation. Assistive technology provides accessibility for students, making it easier for them to acquire knowledge in the Indonesian language. Furthermore, assistive technology can assist students with special needs to work independently, enhance learning motivation, and feel equal rights as regular students.
CINTA DAN DILEMA SANG LIYAN: TELAAH FEMINISME EKSISTENSIALIS TOKOH EMBU’ DALAM CERPEN “SORTANA”
Authors:   Universitas Gadjah Mada, G Wahyu Gandi , Junaidi Ahmad ,   Universitas Gadjah Mada, Ambarwati Suci ,   Universitas Gadjah Mada
Published: March 2024

Women in patriarchal culture are treated unfairly and seen as second-class beings. Their presence is considered as something incidental and not essential. For this reason, this paper examines one of the short stories by Muna Masyari, a female writer from Pamekasan, Madura Sortana. Matchmaking and the myth of the Madurese have put Madurese women in a state of oppression and unfavorable conditions because of the binding culture that dominates women. Muna, using the Sortana short story as a means to advocate for the value of feminism which in the context of Madurese culture is taboo to fight against. This study aims to explore the existence of women who are represented by female characters called Embu. This research method uses qualitative-descriptive research by analyzing the content of the story, looking at sentences and paragraphs related to the issue of the existence of women in Sortana short story. The theoretical concept used is existentialist feminism. From the results of the analysis, it is known that the gender injustice experienced by the Embu character in the short story is in the form of marginalization, subordination, and stereotypes. Meanwhile, through his actions, the Embu figure has the awareness to become the Self in order to be free from the Other.
KEMAMPUAN MENULIS PUISI BERIMA SISWA KELAS X SMA BRAWIJAYA SMART SCHOOL
Authors:   SMA Brawijaya Smart School, Wicaksana Andrean Fahreza Nur , Tabrani Akhmad ,   FKIP Universitas Islam Malang
Published: March 2024

The ability to write rhymed poetry is one of the studies that illustrate students' ability to write poetry using the rhyme method. This is important to do because based on observations, students' ability to write poetry is considered lacking. This study aims to determine: 1) the ability of tenth-grade students of SMA Brawijaya Smart School Malang to write rhymed poetry, viewed from the aspect of sound; 2) the ability of tenth-grade students of SMA Brawijaya Smart School Malang to write rhymed poetry, viewed from the aspect of word positioning. The design used in this research is descriptive quantitative, describing the research variables in the form of numbers or statistics obtained from written test results that portray the ability of tenth-grade students of SMA Brawijaya Smart School Malang to write a rhymed poem. The data in this study was analyzed through five stages: collecting data, identifying data, classifying data, analyzing data, and drawing conclusions. The data processing results in this study show that the ability of tenth-grade students of SMA Brawijaya Smart School Malang to write rhymed poetry is already adequate. Based on the data processing results, it appears that the test results of the tenth-grade students of SMA Brawijaya Smart School Malang in writing rhymed poetry are categorized as good with an average score of 88.
FLIPGRID SEBAGAI MEDIA PEMBELAJARAN DAN PENGOPTIMALAN KETERAMPILAN BERPIDATO PERSUASIF SISWA SMP
Authors:   Universitas Brawijaya, Phroshak Kresna Tribuana Putri , Dewi Putri Kumala ,   Universitas Brawijaya, Rahmiyati Iffah Nur ,   SMP Negeri 10 Malang
Published: March 2024

To train student's speaking skills can be done through Bahasa Indonesia subject, which is by conveying ideas in persuasive speeches orally. It is necessary to support the subject by using a learning media such as Flipgrid. This media features short videos and discussion rooms to make studying more interesting and interactive. This media can motivate students to study deftly as well as hone their speaking skills. The purpose of this study was to determine the learning process and students’s speaking skills in persuasive speeches using Flipgrid. This research uses a qualitative descriptive approach with a case study research type. The subjects were 9th grade students of SMP Negeri 10 Malang, totaling 59 students. The research instruments are questionnaires, observation guidelines, test grids, and assessment rubrics. The results found that in the learning process using Flipgrid had a positive and negative impact on students. The positive impact makes learning more interactive and interesting. Meanwhile, the negative impact hinders the learning process because students do not have adequate laptops or phones to access the media. Then the results found in the students's speaking skills that as many as 20 students were at the very good qualification level, as many as 14 students were at the good qualification level, and no students were at the sufficient or less qualification level. From these results it was found that by persuasive speeches can hone students's learning skills so that they become confident, fully prepared, and fluent in speaking in front of many people.
FARKLI TÜRBÜLATÖRLERE SAHİP DAİRESEL BİR KANALDA TERMAL PERFORMANSIN SAYISAL ANALİZİ
Authors: Akçay Selma
Published: March 2024

Bu çalışmada, içerisinde farklı türbülatörlere sahip dairesel kesitli kanal akışlarının termal performansı sayısal olarak analiz edilmiştir. Simülasyonlar, Hesaplamalı Akışkanlar Dinamiği (HAD) tabanlı Fluent programı ile çözülmüştür. Çalışmada, dik ve eğik bölmelerden oluşan yedi farklı türbülatör yapısı kullanılmıştır. Bu türbülatörler kanalın merkezine yerleştirilmiş ve türbülatörleri içeren kanal dış yüzeyleri sabit sıcaklık (Tw=350K) şartlarında korunmuştur. İki farklı Reynolds sayısı (Re=5000 ve Re=10000) için Nusselt sayısı (Nu), sürtünme faktörü (f) ve termal performans faktörü (TPF) hesaplanmıştır. Sayısal çözümler, önceki çalışma sonuçları ve ampirik bağıntılar ile karşılaştırılmıştır. Türbülatörlerin akış ve ısı transferi üzerindeki etkilerini gözlemleyebilmek için kanal içinde akış ve sıcaklık görüntüleri elde edilmiştir. Yapılan çalışma, aynı zamanda türbülatörsüz kanal akışı ile karşılaştırılmıştır. Elde edilen bulgular, kanal içine eklenen türbülatörlerin ısı transferini iyileştirdiğini ve türbülatörsüz kanala göre Nu 1,38 kat arttığını göstermiştir. Ayrıca kanal giriş hızının artması ile ısı transferi artmıştır. En yüksek ısı transferi Re=10000’de Kanal 8 durumunda Nu=27,17 olarak bulunmuş ve en yüksek TPF Re=5000’de Kanal 8’de TPF=1,08 olarak elde edilmiştir.
TASARIM, SÜREÇ YENİLİĞİ VE DİJİTAL DÖNÜŞÜM İLE TOPLAM VERİMLİLİĞİN ARTTIRILMASINA İLİŞKİN ÖRNEK BİR UYGULAMA
Authors: Özkan Erhan
Published: March 2024

Çalışmanın temel amacı tasarımdan son kullanıma kadar olan süreçlerdeki topyekûn verimlilik artışının detaylı olarak ele alındığı özgün bir çalışmanın literatüre kazandırılmasıdır. Çalışmada tasarım ile ürün verimliliğinin, süreç optimizasyonu ile enerji verimliliğinin, dijital dönüşüm ile operasyonel verimliliğin arttırılmasına ilişkin bilgisayar destekli tasarım, simülasyon, sayısal analiz ve dijital dönüşüm yazılımlarından faydalanılmıştır. Elde edilen bulgular neticesinde tasarım iyileştirme ile ürün veriminde %81,5, süreç optimizasyonu ile enerji ve işçilikte %45, operasyonel verimlilikte ise %55 mertebelerinde artış elde edilerek ülke ekonomisine katkıda bulunacak bir sistem kazandırılmıştır. 3D tasarımlar Solidworks katı modelleme ve tasarım programlarında gerçekleştirilmiştir. Mekanik işlemler ANSYS simülasyon programı kullanılarak sonlu elemanlar yöntemi ile gerçekleştirilmiştir. ANSYS Fluid modu kullanılarak akış katsayısını ve sıvı direnci katsayısını tanımlamak için hesaplamalı akışkanlar dinamiği analizleri yapılmıştır. Üretim parametrelerinin tanımlanması için Anycasting simülasyon programları kullanılmıştır. Dijital dönüşüm kapsamında ülkemizde ilk defa üretim ekipmanları ile hiçbir ara yazılım kullanılmadan haberleşebilen, harici bir yazılım ve lisansa ihtiyaç duyulmadan çalışabilen özgün bir veri izleme sistemi hayata geçirilmiştir.
TAM KAPALI ORGANİK ÇÖZGENLİ VE SULU KUMAŞ YIKAMA SİSTEMLERİNİN EKONOMİK VE ÇAPRAZ MEDYA ETKİ ANALİZİ
Authors: Balkan Meltem , Öztürk Emrah , Kitiş Mehmet
Published: March 2024

Kumaş yıkama proseslerinde genellikle sulu sistem ve çözgen sistem olmak üzere iki yöntem kullanılmaktadır. Bu çalışmada kumaş yıkama proseslerinde kullanılan sulu ve çözgen sistemler Ekonomik ve Çapraz Medya Etkiler Referans Dokümanında sunulan metodolojiden faydalanılarak analiz edilmiştir. Kumaş yıkama sistemleri çapraz medya metodolojisine göre beş farklı çevresel temada karşılaştırılmıştır. Sulu sistemin çözgen sisteme göre beşeri toksisite potansiyeli (BTP), küresel ısınma potansiyeli (KIP), asidifikasyon potansiyeli (AP) ve fotokimyasal ozon oluşturma potansiyeli (FOOP) değerlerinde sırasıyla 1,24, 1,22, 1,24 ve 1,23 kat daha fazla çevresel etkiye neden olduğu görülmüştür. Akuatik toksisite potansiyeli (ATP) açısından çözgen sistemin %100 daha düşük çevresel etkiye sahip olabileceği hesaplanmıştır. Maliyetleme metodolojisine göre ekonomik açıdan değerlendirilen sulu ve çözgen sistemin toplam yıllık maliyetleri sırasıyla 0,34 ve 0,29 USD/kg ürün olarak bulunmuştur. Maliyetleme metodolojisinden elde edilen sonuçlar çözgen sistemin %17 daha verimli olduğunu göstermiştir. Çözgen sistemin net bugünkü değer hesabında, indirgeme oranının %20 olduğu varsayılmıştır. Buna göre sistemin net bugünkü değeri 10.531 USD, yatırımın iç verim oranı ise %26 olarak bulunmuştur.
EFFECT OF THE CURVATURE PARAMETER AND İTS CLASSİFİCATİON ON LANDSLİDES
Authors: Çellek Seda
Published: March 2024

The first question that generally comes to mind about the curvature parameter is whether this parameter is suitable for the study area. This question uses every parameter to be asked, but some effects that are implemented incorrectly, such as curvilinearity, raise question marks. As a result of technical errors and conceptual confusion regarding the parameter, the landslide area defined as concave by one researcher may be defined as convex by another researcher. For this reason, some researchers state that they contradict the literature and produce results contrary to their expectations. Due to such negativities, there is no consensus in the literature regarding curvilinearity parameters. This determination was used for 64 areas selected for curvature parameters in three different classes and the prices of their changes in total. By examining the maximum and minimum distributions in the landslide area, it was investigated what kind of change it caused in concave, convex and flat areas depending on the terrain. As a result of the analysis, it was revealed that class intervals that could not be determined correctly resulted in cracks in the landslide capacity proportional distributions. Thus, the study achieves the main goal that will facilitate the use of the curvature parameter.
MERMER ATIKLARININ PARKE TAŞI ÜRETİMİNDE AGREGA OLARAK KULLANILMASI
Authors: Büyükünsal Ayşe , Akkuş Bilgen
Published: March 2024

Bu çalışmada atık mermerlerin, beton kilitli parke taşlarında agrega olarak kullanılması yöntemi ile yeniden işlevsel hale getirilmesi, kısmen de olsa bu atıkların yönetilerek sürdürülebilirliğinin sağlanması hedeflenmiştir. Deneyler sırasında ilgili TSE Standartları ve Karayolları Teknik Şartnamesinden faydalanılmıştır. Beş farklı (%20 %40, %60 , %80 ve %100) karışım oranında toplamda 60 adet beton parke taşı ve buna ilave olarak 20 adet bir kenarı 10 cm olan küp numuneler hazırlanmıştır. Numunelerin yarısı tuzlu suda yarısı da normal suda bekletilerek priz aldırılmıştır. Beton parke taşı numunelerine su emme oranını belirleme, aşınma direnci, yarmada çekme dayanımı deneyleri uygulanmıştır. Küp numunelere ise basınç dayanımı deneyi yapılmıştır. Su emme oranını belirleme, basınç dayanımı, aşınma direnci deney verilerinin standartların içerisinde kaldığı görülmüştür. Yarmada çekme dayanımı deneyinin sonuçları incelendiğinde ise %20, %40 ve %60 oranında mermer agregası bulunan numunelerin yeterli dayanıma haiz olduğu; ancak %80 ve %100 oranında hazırlanan numunelerin ise dayanımının yetersiz olduğu görülmüştür. Sonuç olarak beton parke taşlarında atık mermerlerin agrega olarak %60 oranına kadar kullanılabileceği tespit edilmiştir.
ŞIRNAK İLİ JEOTERMAL KAYNAKLARI VE ÖZELLİKLERİ
Authors: Davraz Ayşen , Nalbantçılar M Tahir , Kadırhan Gökhan , Ercan İştin Aysen , Çelik Sedat
Published: March 2024

Bu çalışmada, Şırnak ili jeotermal alanları tanıtılarak termal su örneklerinin hidrojeokimyasal özellikleri incelenmiştir. Şırnak ilinde Güçlükonak-Belkıs Ana, Kumçatı (İkizce), Balveren‐Besta ve Beytüşşebap-Ilıcak bölgelerinde jeotermal alanlar bulunmaktadır. İlde en önemli Jeotermal kaynak 63 0C’ye ulaşan sıcaklığı ve mevcut tesisi ile Güçlükonak jeotermal alanındaki Belkıs Ana (Hısta) Kaplıcası kaynağıdır. Diğer önemli jeotermal alan olan Beytüşşebap-Ilıcak bölgesindeki Zümrüt Kaplıcasında 43 0C ile termal su elde edilmektedir. İlde farklı yaştaki karbonatlı kayalar jeotermal sistemin rezervuar kayalarını oluşturmaktadır. Marn ve killi litolojiler örtü kaya niteliğindedir. Jeotermal sistem ise tektonik kontrollüdür. Termal suların pH değerleri 6,56-9,46 arasında ve EC değerleri 756-2095 µS/cm arasında değişmektedir. Sularda farklı su tipleri (Ca-Mg-HCO3-SO4/ Ca-Mg-SO4-HCO3, Na-Ca-Cl-HCO3/Na-Ca-HCO3-Cl) tespit edilmiştir. Şırnak ilinde termal suların kimyasını denetleyen temel faktörün kaya-su etkileşimi olduğu görülmektedir. Termal su örneklerinin As içeriği 11-22 µg/l arasında değişmekte olup içme suyu için verilen sınır değerleri aşmaktadır. Ayrıca, Mn, Se ve koliform bakteri içeriklerinin bazı örneklerde sınır değerlerin üzerinde olduğu tespit edilmiştir.
ANTALYA BÖLGESİNDEKİ KONAKLAMA TESİSLERİNDE DOĞRUDAN SU KULLANIMININ İNCELENMESİ
Authors: Şahin Handan , Topkaya Bülent , Civelekoğlu Gökhan
Published: March 2024

Bu çalışmada Türkiye’nin turizm sektöründe çok önemli yere sahip olan Antalya’da sektörün doğrudan su tüketimi, belirlenen turizm tesislerinde incelenmiştir. Doğrudan su tüketimine çamaşırhane, mutfak, odalar, genel mekanlar ve sulama suyu vb. alanlardaki faaliyetler neden olmaktadır. Bu çalışmada, tesis tipine bağlı olarak doğrudan su tüketimi farklılıkları tespit edilmiştir. Bu kapsamda Antalya’da farklı ilçelerde bulunan, 2 tane 5 yıldızlı tatil köyü, 8 tane 5 yıldızlı otel, 8 tane 4 yıldızlı otel, 1 tane müstakil apart otel ve 1 tane apart otel olmak üzere toplam 20 tane konaklama tesisinde aylara göre doğrudan su tüketimi verileri temin edilerek, geceleme başına su tüketimi hesaplamaları yapılmıştır. Doğrudan su tüketiminin değerlendirilmesi amacıyla, 5 yıldızlı bir konaklama tesisinde, portatif ultrasonik debimetre ile 3 gün boyunca 15 dakika arayla debi ölçümü gerçekleştirilmiştir. Tesis doğrudan tüketimi bölümlere göre ölçülmekte olup, birimlere göre dağılımı ayrıca değerlendirilmiştir. Doğrudan su tüketiminin farklı tip tesislerde 103–1209 L/geceleme arasında değişiklik gösterdiği tespit edilmiştir.