bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Drugs Recently Authorized by EMA and FDA (Q3, 2022)
Authors: Cuéllar Rodríguez Santiago
Published: October 2022

EMA (EUROPEAN MEDICINES AGENCY)
(A) TRACTO ALIMENTARIO Y METABOLISMO: Avalglucosidasa Alfa (Nexviadyme®): enfermedad de Pompe; Eladocagene Exuparvovec (Upstaza®): deficiencia de L-aminoácido descarboxilasa aromática (AADC); Lonafarnib (Zokinvy®): progeria de Hutchinson-Gilford; Olipudasa Alfa (Xenpozyme®): déficit de esfingomielinasa ácida (ASMD). (B) SANGRE Y SISTEMA HEMATOPOYÉTICO: Eptacog Beta activado (Cevenfacta®): hemofilia; Valoctogene Roxaparvovec (Roctavian®): hemofilia. (D) DERMATOLOGÍA: Abedul, extracto (Filsuvez®): epidermolisis bullosa. (G) SISTEMA GENITOURINARIO Y HORMONAL SEXUALES: Linzagolix (Yselty®): miomas uterinos. (J) ANTIINFECCIOSOS SISTÉMICOS: Vacuna COVID-19 ARN bivalente (Comirnaty Original/Omicron BA.1; Spikevax Bivalent Original/Omicron BA.1): profilaxis de la COVID-19; Vacuna COVID-19 inactivada (Vacuna COVID-19 Valneva®): profilaxis de la COVID-19; Vacuna Hepatitis B recombinante (Prehevbri®): profilaxis de la hepatitis B; Vacuna Neumococo polisacárida conjugada 20-valente (Apexxnar®): profilaxis de la enfermedad invasiva y la neumonía causadas por Streptococcus pneumoniae; Lenacapavir (Sunlenca®): VIH/SIDA. (L) AGENTES ANTINEOPLÁSICOS E INMUNOMODULADORES: Capmatinib (Tabrecta®): cáncer de pulmón; Asciminib (Scemblix®): leucemia mieloide crónica; Teclistamab (Tecvayli®): mieloma múltiple; Edgartigimod Alfa (Vyvgart®): miastenia gravis. (N) SISTEMA NERVIOSO: Lasmiditan (Rayvow®): migraña.FDA (U.S. FOOD & DRUG ADMINISTRATION)
(A) TRACTO ALIMENTARIO Y METABOLISMO: Vutrisiran (Amvuttra®): amiloidosis. (L) AGENTES ANTINEOPLÁSICOS E INMUNOMODULADORES: Spesolimab (Spevigo®): psoriasis; Deucravacitinib (Sotyktu®): psoriasis; Eflapegrastim (Rolontis®): neutropenia. (M) SISTEMA MÚSCULO-ESQUELÉTICO: Toxina Daxibotulínica A (Daxxify®): arrugas glabelares.
The Storyteller of Environmental Consciousness: S. R. Harnot
Authors: Kumar Parshotam
Published: October 2022

Environmental protection is an important issue at present. Due to climate change, global warming, pollution, depletion of ozone layer, increase in temperature, etc., there is a danger of extinction of many species on the earth. There is continuous discussion on natural imbalance and environmental issues. Many writers of Hindi are also writing on this. S. R. Harnot is constantly raising these issues directly and indirectly in his stories, forcing the reader to think.

Abstract in Hindi Language:

वर्तमान में पर्यावरण संरक्षण एक महत्वपूर्ण मुद्दा है। जलवायु परिवर्तन, ग्लोबल वार्मिंग, प्रदूषण, ओजोन परत का ह्रास, तापमान में वृद्धि आदि के कारण धरती पर कई प्रजातियों के नष्ट होने का संकट छाया है। प्राकृतिक असंतुलन तथा पर्यवरणीय मुद्दों पर निरन्तर विचार-विमर्श हो रहा है। हिन्दी के कई लेखक भी इस पर लेखनी चला रहे हैं। एस. आर. हरनोट अपनी कहानियों में प्रत्यक्ष अप्रत्यक्ष इन मुद्दों को निरन्तर उठाकर पाठक वर्ग को सोचने के लिए मजबूर कर रहे हैं।

Keywords: पर्यावरण, देव-पंचायत, जातरा, प्राकृतिक असंतुलन
Possible analogies of the written stones from the Tászok Peak, in particular those in the Moldavian areas
Authors: Puskás-Kolozsvári Frederic
Published: October 2022

The analogies of the written stones from the Tászok Peak can be found along the routes passing through the border areas of Transylvania and Moldavia, including the so-called Salt Road that connected the Salt Region (Sóvidék) in the district of Udvarhelyszék with the region of Moldvabánya (Baia) and the so-called Beszterce route connecting Beszterce (Bistrița) with Karácsonkő (Piatra Neamț). The third road connected Szászrégen (Reghin) with the region of Ditró (Ditrău), from whence the road lead through Pricske to Tölgyes (Tulgheș) and Moldova (Western Moldavia) and through the Tászok to Bélbor (Bilbor) and Bukovina. My observations suggest that the written stones found in the Szeklerland and the Moldavian areas are mainly connected to the Anjou-Era network of commercial roads used during the 14th–18th centuries between Transylvania and Moldova. The sites listed in this study are: Firtos (Firtușu) Peak, Szertő Peak, Bekecs (Bichiș) Peak, Kereszt (Crucii) Mountain, Salamás (Sărmaș) Creek, Tászok (Tasoc) Peak, Pricske (Prișca) Peak, Zsedán (Jedanu) Creek, Hajtó (Haita) Creek, Írottkő (Piatra Scrisă) Peak, Herla and Radocsány (Rădășeni). All of them can be associated with the commercial road network from the Middle Age and the Age of Principality, which partly remained in use until the 19th century
Variations on continuity in light of the graphemes of Regöly
Authors: Szabó Géza
Published: October 2022

When examining continuity in the Carpathian Basin, it is particularly justified to highlight the line of the Iranian ethnic groups, especially as the names of Hungary’s largest rivers may be attributed to them; we can follow the continuity of some of the geographical names from the Iron Age. Continuity prevailed not so much in the territorial or ethnic sense, but mainly through the presence of common traditions, ethnic bases or elements of civilisation, i.e. in the frames of cultural continuity. In the background, there are peoples with Iranian roots coming from virtually the same cultural sphere – mostly from similar ethnic groups which were not necessarily genetically related – breaking away in recurring waves and settling in the Carpathian Basin and in other parts of Europe at various times. The results of modern genetic, linguistic and other analyses are frequently conflicted due to the traditional approach built on local ethnic continuity and to the continuous cultural and often ethnic over-layering. It will be possible to interpret these analyses more accurately, adjusted to their higher resolution of information, if we take into consideration that the survival of the same ethnicity is not absolutely necessary in a specific territory for the continuous presence of certain cultural elements and if we also take account of the new waves of settlers coming from the same culture.
Weapon inscriptions in Latin script from the 9th–12th-century Carpathian Basin
Authors: Haramza Márk
Published: October 2022

In the history of arms and armours, the study of various symbols, inscriptions or trademarks is of great importance both in determining the provenance and the development of weapons. Numerous weapon inscriptions – usually found on swords – are known from the 9th–12th-century Carpathian Basin. In addition to the prevalent Ingel-variants, we can expect the presence of various texts, letter combinations and letter-like characters in the region. This study provides a brief overview of these weapon inscriptions.
Runiform signs or mementos of Christianisation?
Authors: Langó Péter
Published: October 2022

This paper reviews the research on a ring type appearing in Carpathian Basin cemeteries in the 11th century. In this paper, I present the early attempts to interpret the engraved signs on the rings and the related explanations. Following an overview of the historical developments, I make a brief suggestion that the signs on the rings were not always understandable; it cannot be ruled out that the makers of the rings may not have been able to write, while the customers could not read. This hypothesis would raise further considerations and possibilities when interpreting this group of artefacts.
The runiform script from Káposztásmegyer that nobody believed in
Authors: Fehér Bence
Published: October 2022

In 1971, two potsherds containing written characters in the Szekler runiform script were found in Káposztásmegyer (Budapest, District IV) while moving earth. Although they were identified as medieval products, the sherds have been regarded as forgeries ever since. However, the larger fragment was written before firing and is thus an original specimen. Although its exact origins are unknown, it is reasonable to assume that it is an artefact from the 15th or the early part of the 16th century. The first verse of the inscription is not intelligible, the second one says [- - -]+uk rótt am [- - -?]. As it is a domestic product of inferior quality, the existence of the runiform characters is hard to explain (in all likelihood, it was made locally); most probably it can be linked to the cult of Szekler runes in the era of King Mátyás; it may have been the product of a potter who worked for an aristocratic or clerical landowner.
Antimalarial activity prediction analysis of sticophus hermanni on plasmodium falciparum hexose transporter (PfHT1)
Authors: Utami Prawesty Diah , Yudho R. Varidianto
Published: October 2022

The objective of this study is to investigate S.hermanni's antimalarial action against PfHT1 utilizing an in silico technique. In silico method, developing a protein target database by searching and collecting the protein target structures from the Protein Data Bank (PDB) and the UNIPROT databases. PfHT1 protein (PDB ID 6m20) with glucose control. Download all ligand structures from the PubChem database. Molecular docking analysis with Molegro virtual docker predicts interactions between ligands and protein targets. The last step was docking visualization to display 3D views and their interactions with the discovery studio program. The control compound beta-D-glucopyranose binds PfHT1 at the active site GLN169, GLN305, ASN341, GLY408, ASN311, and GLN305. All active compounds of S.hermanni were able to bind to PfHT1. This indicates that all active compounds enter the cell via hexose transporter 1 (PfHT1) receptors, such as glucose. All active substances of S.hermanni have antimalaria activity through PfHT1inhibition. Almost all active substances used were similar to the control binding sites, but only quinoxaline used different binding sites. The active substance of S.hermanni has a variety of binding affinities to PfHT1.
Edible Cutlery: A Sustainable Alternative to Plastic Cutlery for a Better Future
Authors: Zahra Naseem , Imran Ali , Saeed Muhammad Khalid , Arif Kiran , Syed Quratulain , Imam Abdi Syed Hussain
Published: October 2022

Edible cutlery is an excellent concept to reduce the use of plastic cutlery and to save human health from the harmful effects of plastic utensils. Surveys revealed that only a negligible portion of the total plastic waste is recycled. The rest is added to the environment and contribute to pollution. Each year tonnes of plastic cutleries are dumped in the oceans and other water bodies which is affecting the life in water. Humans eat food in plastic utensils and pollute environment by burning too. The unsafe high levels of the plastic waste are not good for both environment and living organisms, either humans or animals. To cut down the usage of plastic products to the safe levels, some safe alternatives are needed. Edible cutlery can serve as a sustainable alternative to the plastic cutlery because it’s biodegradable and edible.  Edible cutlery is made of safe-to-eat ingredients like wheat, rice and sorghum. Edible cutlery may be vegan-friendly with natural spices and flavors. It requires no additives or preservatives. Environmental pollution in Pakistan can be controlled significantly by promoting the use of edible cutlery like the other countries. Edible cutlery is the best solution to spread awareness regarding environmental issues due to plastic use. This review entailed the benefits of edible cutlery usage for the betterment of human health
Debris Flow Hazard Assessment in District Chitral, Eastern Hindu Kush, Pakistan
Authors: Mahmood Shakeel , Atiq Attia
Published: October 2022

The aim of this study is debris flow risk zonation using geological and hydrometeorological indicators in district Chitral, Hindu Kush Region Northwest Pakistan. The research is based on secondary data. Multi criteria Analysis (MCA) in Geographical Information System (GIS) environment was used to achieve the objective of the study. The geological and hydrometeorological parameters were analyzed by making five classes of each parameter. The classes are ranked as most favorable and least favorable with numerical weights. The weights were assigned in accordance to their importance in debris flow occurrence. Then weighted overlay analysis techniques were applied to develop composite map representing the importance of each factor. Debris flow risk zonation map was resulted into four classes very high risk zones, high risk zone, moderate zone, low risk zone. The geology of the study area is diverse with frequents earthquakes. Similarly the forest cover is decreasing due to anthropogenic activities. The area is also characterized by long cold winters with frost action. These factors are destabilizing the slope. During summer season rain storm event results high surface runoff and peak discharge in the perennial and non-perennial channels which results flood and debris flow. These events result human life loss and disruption.  The main villages located in very high risk zone are Mulkoh, Mastuj, Reshun, Shegram, Terich Gol, Rogar, Asurat, Boni, Brep and Rech Tockhow. They have been frequently affected by hazard in the past decade. Out of the total area, very high risk zone is expanded over 8%, high risk zone is expanded over16%, moderate risk zone is 29% and the rest is low risk zone. This study has highlighted the risk zones which will help disaster management authorities and policy makers to reduce the risk of debris flow in future.
DERİ ÜZERİNE EBRU BOYAMA TEKNİĞİNİN ÖRNEK ÇALIŞMA BAĞLAMINDA DEĞERLENDİRİLMESİ
Authors: ATALAN Dilara Nur , DEMİR Özcan , CORUH Ebru
Published: October 2022

Geleneksel Türk Sanatları alanında yüzyıllardır var olan ebru sanatı ve dericilik başlangıçta ihtiyaçları karşılamak amacıyla ortaya çıkmıştır. İlerleyen zamanlarda birer sanat olarak icra edilmeye başlanmıştır. Ebru sanatı farklı birçok materyal üzerine uygulanmaktadır. Sürekli olarak gelişmekte ve kullanım alanını genişletmektedir, moda, aksesuar, ayakkabı, çanta, tekstil gibi pek çok alanda kullanılmaktadır. Dericilik yaşam koşullarından korunmak amacı ile ortaya çıkmış ve işleme yöntemlerinin keşfedilmesi sonucunda bir sanat haline gelmiştir. Pek çok deri çeşiti ve süsleme teknikleri bulunmaktadır. Deri günümüzde çanta, cüzdan, ayakkabı, ceket, aksesuar, moda ve mobilya sektöründe tercih edilmektedir. Dayanıklı, sağlam ve esnek olması ile uzun yıllar boyunca kullanılmaktadır. Deri süsleme tekniklerinden biri olan boyama tekniği ebru sanatı bağlamında ele alınmıştır. Çalışma kapsamında ebru sanatı keçi derisi üzerine uygulanmıştır. Türk Sanat tarihinde önemli yerlere sahip olan ebru sanatı ve dericilik özellikleri, tarihçeleri ve çeşitleri ile aktarılmış ve bir arada kullanılarak ürünler elde edilmiştir. Örnek çalışmaların aşamaları fotoğraflanarak açıklanmış ve elde edilen sonuçlar yorumlanmıştır.
A Comparative Evaluation of the Effect of Ozonated Water and 2% Glutaraldehyde as disinfectants on the physical properties of polyvinyl siloxane impression material – An Invitro study
Authors:   Department of prosthodontics &crown and bridge Azeezia college of dental sciences and research, JABBAR JASNA , VARGHESE KURIEN , THOMAS WILLIAM , TAJ SHAHANA , S VISHNU
Published: October 2022

Aims: To compare the efficacy of ozone water and 2% glutaraldehyde in disinfecting polyvinyl siloxane impression and the effect of both disinfectants on the wettability, dimensional accuracy and surface detail reproduction of the material. Settings and Design: In vitro – comparative study Material and Methods: Samples (N =108) were subjected to disinfection either with 2% glutaraldehyde (group 1) or ozone water (group 2) for 15 minutes. To evaluate the efficacy, the samples were inoculated with Streptococcus mutans [ATCC 25175], Staphylococcus aureus [ATCC 25923] and Candida albicans [ATCC 10231]. Reductions in the number of microbial population after disinfection were determined by counting the colony forming units (CFU). The contact angle measurements on the impression surface were used to determine the wettability. Dimensional accuracy and surface detail reproductions of the samples were assessed with a stereomicroscope of 4X magnification. Statistical analysis used: paired t- test and chi-square test were used. Results: The efficacy of both disinfectants in reducing the microbial count found to be comparable. Both the disinfectants reduced the contact angle which improved the wettability of the material. Disinfection with 2% glutaraldehyde showed significant alteration in dimensional accuracy and surface detail reproduction (p<0.05) when compared to samples disinfected with ozone water, which preserves the dimensional accuracy and surface details. Conclusions: Ozone water treatment was identified as a potential method for the disinfection of polyvinyl siloxane impression as it increased the wettability of the material, showed least dimensional changes and preserved surface details more accurately.
Esthetic reconstruction with cheek plumpers: A case report
Authors:   KMCT DENTAL COLLEGE, KOZHIKODE, P LOKESH EAKETHA , C SWAPNA , M SHEEJITH
Published: October 2022

Ageing and long span edentulism is associated with loss of teeth, alveolar ridge resoprtion, and loss of support and tonicity of facial muscles. This is a great concern in treating completely edentulous patients. Flaccid facial musculature eventually results in sunken cheeks and unesthetic appearance, causing a negative impact on psychological well-being of the patient. Prosthetic rehabilitation of completely edentulous patient with conventional complete denture doesnot confine to replacement of missing teeth, but may require additional support in some instances. The present clinical report exemplifies the use of non-detachable maxillary cheek plumper prosthesis in a completely edentulous patient with sunken cheeks.
Single Anterior Tooth Replacement By Maryland Bridge With Loop Connector: A Case Report
Authors:   Y.C.M.M. and R.D.F’S Dental College, Ahmednagar, V.N.V. Madhav , Patil Priyanka
Published: October 2022

Restoring a single missing tooth in the mandibular anterior region is often a great concern to the dentist because it requires unnecessary removal of healthy abutment tooth structure. Also because of the drifting of the teeth may reduce the available pontic space or presence of diastema before can result in excessive mesiodistal space which again compromises the aesthetics. When the patients demand more conservative and less invasive treatment options, a combination of Maryland Bridge with a loop connector may be the best alternative option to restore the missing teeth whenever the diastema is present. It is the modification of resin bonded FPD which offers a simple solution when the above dilemma is present. It consists of a loop on the lingual aspect, joining the pontic in the center, and then attaches to the wing retainer on the abutment tooth. This case report provides a straightforward and innovative method for the fabrication of modified resin bonded FPD along with maintaining diastema.
A Study on Inventory Management in Dora Plastics, Pvt Ltd Tirupati
Authors: Babu K. Harish , Chandrika Dr. N.
Published: October 2022

The aim of the study is to examine the inventory management process. The significance of this research is based on the benefits that can be obtained by identifying the issues of inventory control. The methodology used on-site study, and annual report analysis. Inventory management is an important area of manufacturing industry. If company fails to manage inventory, they will face failure. It is a challenge for the company to maintain fair inventory. There are various inventory management techniques available for maintaining fair inventory level in the company. The basic objective of this paper is to study about inventory management techniques used in Dora plastics pvt ltd. and find out some measures for improvement on inventory management process of the concerned company. The present system of inventory management of the company is good. For improvement of the present inventory management system, company should adopt other inventory management techniques.
Strategi Komunikasi Pada Komunitas Perempuan “Selaksabaya” Kabupaten Blitar dalam Memperkenalkan Kebaya di Apilkasi Tiktok
Authors: Andiwi Meifilina
Published: October 2022

Kurangnya antusiasme dari para perempuan di Kabupaten Blitar dalam melestarikan budaya berkebaya, maka Selaksabaya harus memiliki strategi komunikasi untuk memperkenalkan budaya kebaya. Rumusan masalah penelitian ini yaitu bagaimana strategi komunikasi Selaksabaya dalam memperkenalkan kebaya menggunakan aplikasi TikTok dan faktor apa saja yang mendukung dan menghambat strategi komunikasi Selaksabaya dalam memperkenalkan kebaya menggunakan aplikasi Tik-Tok. Peneliti menggunakan teknik purposive sampling, yaitu dengan menetapkan sejumlah informan dengan kriteria tertentu. Teknik pengumpulan data dalam penelitian ini menggunakan observasi, wawancara dan dokumentasi. Model Hierarchy Effect yang digunakan adalah untuk menginformasikan (to inform) dan membujuk (to persuade). Masing-masing fungsi tersebut memiliki tahapan-tahapan tertentu. To Inform (menginformasikan) memiliki tiga tahap sedangkan untuk membujuk memiliki empat tahap. Adanya faktor pendukung atau penunjang strategi komunikasi Selaksabaya Kabupaten Blitar dalam memperkenalkan kebaya menggunakan aplikasi TikTok yaitu penggunaan media sosial tidak menggunakan biaya, baik dalam penggunaan aplikasi TikTok, Facebook maupun Instagram. Hal ini membuat lebih mudah untuk mengembangkan bentuk promosi mereka. Faktor penghambat dalam strategi komunikasi adalah kurangnya fasilitas admin media sosial.
“An Analysis on Email Classification on Hindi Language using Bayesian Classifier”
Authors: Tamhankar Dr.Ishaan , Bhatiya Ms.Ritu
Published: October 2022

Spam messages are one of the most important problems on the Internet today, costing businesses money and causing frustration to individual users. Spam filtering can assist with the issue in a variety of ways. The classifier-related challenges have been the focus of several spam filtering studies. Machine learning for a spam classification is now a significant research topic. The application of various machine learning techniques for categorizing spam messages from e-mail is investigated and identified in this research. Finally, with spam categorization, a comparative study of the algorithms has been presented.
Theoretical Models Of Technology Acceptance: A Critical Analysis & Design For Future Research
Authors: kumar Dr. Dinesh , Ahmad Abdulhamid Sanusi
Published: October 2022

This study reviews literature on various technology acceptance models critically focusing on their findings, suggestions and recommendations for future research. The primary purpose of reviewing technology acceptance models was to establish that with the passage of time, many new models emerged by dwelling on the strengths and weaknesses of previous models. So, critical analysis was presented to understand the framework and constructs of different technology acceptance models. Content and reviews on technology acceptance models were identified using authentic database searches like Springer, JSTOR, WebQuest, ProQuest, ResearchGate, Shodhganga etc. In the end, the study highlights the research gaps in technology acceptance in different parts of the world and designs the theoretical framework for new technology acceptance models, particularly for the acceptance of blended learning systems. A comprehensive understanding of this new framework can assist decision makers to identify the reasons for the acceptance or resistance of blended learning among teachers in the future and support them to enhance the acceptance and usage.
Superior Short circuit & Overcurrent Protection of Devices like Alternator, Transformer etc.
Authors: Ahammed Md. Tabil , Hossain Shadat , Hasan Md. Mehedi , Rabby Golam , Huda Nazmul
Published: October 2022

Improved motor, controller and branch circuit protection has been the subject of a never-ending stream of magazine articles, IEEE papers and amendments to the National Electrical Code. Combining motor short-circuit protectors and properly certified motor controllers may provide superior branch circuit overcurrent protection. An Alternator, Transformer, and Other Devices with Superior Short Circuit and Overcurrent Protection are discussed in this study.
Optimization of Energy Conversion Efficiency of PV System
Authors: A Fowsiya P , P Rajesh , G Rajkumar , K Maheswaran
Published: October 2022

The call for energy is hastily rising, and renewable electricity reassets have become more and more more vital for retaining the electrical gadget and servicing remoted demands. Solar electricity, wind electricity, and tidal electricity are all examples of renewable electricity. The sun electricity gadget is clean, and great quantities of sun radiation attain the earth`s surface. The purpose of this observes is to optimise the amount of electrical strength extracted from a sun electricity gadget. This paper delves into the belief of MPPT techniques, which could raise the performance of a sun PV gadget dramatically. This paintings offers a simulation-primarily based totally evaluation of the maximum used processes for optimising the electricity conversion performance of PV systems, perturb and study and incremental conductance techniques. The PV module's houses are decided through simulation evaluation and outcomes.
Het contracteren van cloudcomputing (SaaS) – oplossingen
Authors: van Reeken B.L.P.
Published: October 2022

Het contracteren van cloudcomputing (SaaS) – oplossingen

Voor het onderhandelen over SaaS-overeenkomsten en software licenties bespreekt deze bijdrage de verschillen daartussen, het bedrijfsmodel van veel leveranciers en de belangrijkste aandachtspunten.
THE ROLE OF THE MOTOR ANALYZER IN THE DEVELOPMENT OF SPEECH ACTIVITY IN PRESCHOOL CHILDREN
Authors:   Doctor of Philosophy In Pedagogical Sciences (Phd), Department Of Special Pedagogy Chirchik State Pedagogical University, Uzbekistan, Achilova Sevara
Published: October 2022

This article discusses the role of the motor analyzer in the development of speech activity in preschool children.
TRANSFORMATION AND DEVELOPMENT OF INDUSTRY IN THE DIGITAL ECONOMY
Authors:   Doctor Of Economic Sciences, Professor, Uzbekistan, Nematjonovna Mahmudova Guljahan , Olimovna Rakhmatullaeva Dilbar ,   Assistant Of The Department Of Economic Theory Of The National University Of Uzbekistan Named After Mirzo Ulugbek, Uzbekistan
Published: October 2022

It is predicted that by 2020 the market for robotics and artificial intelligence products will grow to 142 billion euros. By 2025, the automation of information, labor, robotics and autonomous cars is expected to have a combined economic impact of 6.5 trillion euros and 12 trillion euros per year, including productivity gains and benefits in sectors such as safety and healthcare.
THE IMPORTANCE OF INVESTMENTS IN THE DEVELOPMENT OF AGRICULTURAL SECTORS
Authors:   Termiz Institute Of Agrotechnologies And Innovative Development Student Of Agribusiness And Investment Activities, Uzbekistan, Qahramon Omonova Nafisa
Published: October 2022

In this article, the author expresses her opinion about the importance and relevance of investments in the development of agricultural sectors. Also, the article analyzes data on the example of tourism as an industry.
UKRAINIAN EXPERIENCE IN DEVELOPING THE BEEKEEPING NETWORK IN OUR COUNTRY
Authors:   Karshi Institute Of Engineering And Economics, Senior Teacher, Uzbekistan, Farmanov J.
Published: October 2022

This article discusses the development of the beekeeping industry in the world, the leading countries in its cultivation and export, their share, the experience of growing and exporting honey in Ukraine, and also developed recommendations for its implementation in our country.
THE ROLE OF DEWORMING IN THE HEALTHY CARE OF HORSES
Authors:   Candidate Of Science., (Samvmu Nb, Veterinary Department), Uzbekistan, Yuldashevich Arziev Khidir
Published: October 2022

This article presents the results of examination of horses for helminthiasis in Ellikkala district. The average incidence of helminth infestation in the examined horses was 6.6%, stronglidiosis -6.6%, and parascaridiosis -20%. The overall infestation with helminths averaged 33.3 percent. “Panafenb”, a 22.2% drug for helminthiasis in horses, was found to be effective when given orally (per os) in the form of granules to horses in the amount of 1.0 g per 34 kg of live weight.
CULTURE IS A CERTAIN LEVEL OF HISTORICAL DEVELOPMENT OF SOCIETY, HUMAN CREATIVE POWER AND ABILITIES
Authors:   Student Direction Of Organization And Management Of Culture And Art Institutions Faculty Of National Dress And Art, Termez State University, Uzbekistan, Makhmudova Aziza A.
Published: October 2022

Culture is a set of symbolic devices and works that define human activity and the importance of this activity. Culture can be manifested in activities such as music, literature, visual arts, architecture, theater, cinematography, and lifestyle. In anthropology, the term “culture” refers to products and their production, aesthetic meaning, and social relations connected to these processes. In this sense, culture includes art, science, and spiritual systems. Culture is a certain level of historical development of society, human creative power and abilities. It is expressed in various forms of people’s life and activities, as well as in the material and spiritual wealth they create. The concept of culture is used to explain a specific historical period (ancient culture), concrete society, people and nation, as well as specific areas of human activity or life. In a narrow sense, the term culture is used only in the sphere of the spiritual life of people. Culture comes from the Arabic word madina (city). Arabs divide people’s lives into two types: one is Bedouin or desert life; the second is called cultural life. Bedouins are nomadic peoples living in the steppes and deserts, culturalism is used for peoples who live in cities and have their own way of life.
Wybrane obszary bezpieczeństwa
Authors: Górczyński Dariusz
Published: October 2022

This monograph is a collection of studies which, due to the content presented, have been divided into two conventionally adopted thematic areas. The first one contains studies on shaping a sense of security in the conditions of the prevailing COVID-19 pandemic. The empirical considerations presented in this section focus on the assessment of consumer behavior in the pandemic era and issues focused on ensuring the safety of travelers by air carriers in specific conditions. The second part of the monograph presents scientific considerations and their results, which are of a diverse nature, because they concern both the issues of military aspects of shaping security, mainly in the international dimension, as well as issues related to threats resulting from the technical development of various spheres of human life and activity, with particular emphasis on the development of unmanned aerial vehicles. air systems, intelligent weapons, information and satellite systems
Diffusion of participatory budgets in Poland: do neighbours matter?
Authors: Wetoszka Piotr
Published: October 2022

Objective of the study: The subject of the study are participatory budgets – social innovations used by local municipalities to involve citizens in local budgetary decisions with roots in Brazil. The main objective was to determine how being part of a social network affects the decision to introduce participatory budgets made by municipalities in Poland, where a remarkable spread of the innovation has been observed since the early 2010s.Methodology: Spatial autocorrelation tests and visualizations were used to uncover clusters of communes with most similar or dissimilar characteristics.Originality/Relevance: Novelty of the study approach lies in the utilization of an own database ­­– with the intention to overcome the problem of data insufficiency, typical of related research.Main results: The presence of spatial proximity-based peer effects was confirmed in the study. The concentration of innovators has remained spatially uneven, which is to be linked to e.g. the cross-regionally diverse forms of social capital. The data-based study design allows to explore participatory budgets as products of social networks and not only individual strategies, as evidenced by numerous case studies in the field.Methodological contributions: The study demonstrates the relevance of collecting longitudinal data for the development of research on participatory budgets.Social/management contributions: Insights from the study are of practical value for recent and future. adopters, wishing to understand the broader relevance of their policies, as well as for  higher level policy-makers trying to better adapt their legal frameworks to the current and future waves of innovators.
A systematic review of the literature on the application of blockchain in the health supply chain
Authors: Araújo Andre Ricardo Cavalcanti , Santos Igor Leão dos , Reis Augusto Da Cunha
Published: October 2022

Objective of the study: This article aims to present a systematic literature review on the application of blockchain in the healthcare supply chain.Relevance / originality: The relevance and originality consist in the presentation of a systematic literature review that focuses and considers the concepts of blockchain, healthcare and supply chain as equally important, in the studied time frame.Methodology / approach: The systematic literature review followed a protocol based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), performing the search in eight databases, selecting conference and journal articles based on their content in sequential steps.Main results: As a result, 122 publications were selected. The number of publications in the field has been found to grow rapidly, and sensors and the Internet of Things (IoT) are two prominent minor topics. Three research challenges were raised.Theoretical / methodological contributions: Provide understanding to academics and professionals in the field about the state of the art of applying the blockchain in the healthcare supply chain, both in terms of the evolution of the literature, as well as in terms of raising new research.Social / management contributions: Raising discussions on solutions to healthcare supply chain issues, involving for example data integrity and privacy in electronic medical reports, drug counterfeiting and the use of sensors and the internet of things.
Effect of total mixed ration (TM R) briquettes on milk yield, composition and sensory properties of cow milk
Authors: KARUNANAYAKA R H W M , NAYANANJALIE W A D , WEERASINGHA W V V R , SOMASIRI S C , KUMARI M A A P , ADIKARI A M J B , MANGALIKA U L P , SUNDARABARATHY T V
Published: October 2022

The current study aimed to assess the effect of feeding total mix ration (TMR) briquettes on milk composition, yield and sensory attributes. Jersey × Sahiwal crossbred cows (Nine) were randomly assigned to three treatments (CTL: guinea grass with commercial feed, TMR1 and TMR2: TMR briquettes) in a 3 × 3 replicated Latin square design. Daily milk yield was recorded and milk composition was measured at three days intervals. At the end of each period, fatty acid composition, calcium, phosphorus and sensory properties of milk were analysed. Milk yield trended to be higher in cows fed with TMR briquettes and milk fat content was similar among the treatments. There was no significant difference in milk fatty acid profile among the treatments; however, lauric acid (C12:0) concentration was significantly higher in milk obtained from the cows fed with TMR1 briquettes. Milk calcium and phosphorus contents did not show any significant difference. All the sensory attributes were significantly higher in milk tested from cows fed with TMR1. The present study revealed that feeding TMR1 briquette could be one of the strategies to overcome the inconsistent milk yield reported during the forage scare periods without affecting the milk composition, and fatty acid composition with better sensory attributes.
Localization and characterization of SSCs from pre-pubertal bovine testes
Authors: WARDAK MOHAMMAD KAZIM , KULATHUNGA KAUSHALYA , PRIYADARSHANA CHATHURA
Published: October 2022

Self renewal and proliferation ability of spermatogonial stem cells (SSCs) support spermatogenesis during adult life. Theoretically, these stem cells can be utilized for transmission of genetic information to descendants via testicular transplantation. However, lack of knowledge in methodologies for identification of SSCs limits the application of SSCs transplantation in domestic animals. Accumulated studies have shown that SSCs specific markers (DBA, UCHL1) and stem cell marker (Sox2, Oct4) are useful to screen SSCs that able to be used for transplantation. However, in cattle, less information is available on the expression status of these markers till date. Therefore, a study was carried out in 2019 at Tsukuba University, Japan where testes from 3, 5 and 7 months old calves were utilized to examine testicular localization and in vitro propogation of stem cell markers. SSCs were isolated by enzymatic digestion combined with centrifugal separation on discontinuous Percoll density gradient. Cell propagation and SSCs marker expression were determined at 5, 10 and 15 days post-culture. Immunostaining in conjunction with Western Blot analysis of cultured cells showed that stem cell markers (UCHL1, Oct4 and Sox2) were expressed in SSCs suggesting that differentiation of gonocyte started by 3 months and SSCs differentiation begins after 5 months of age. Taken together, these results demonstrated marker expression and localization of bull SSCs and showed that in vitro culturing of bull SSCs is implementable.
The ritual of taking the military oath
Authors:   Ph.D., Senior expert of the service for the formation of the  archive  of  the  president of  the Republik of Kazakhstan, Suleimenova A.S.
Published: October 2022

The article analyzes the official data in administrative and administrative documents formed during the activities of the President of the Republic of Kazakhstan, deposited in the Archive of the President of the Republic of Kazakhstan, concerning the military oath of employees of the Armed Forces of the Republic of Kazakhstan. It is known that the first step in the work of a serviceman begins with taking the Military oath.Army General Sagadat Kozhakhmetovich Nurmagambetov painstakingly worked on the adoption of a valuable document at the first step of a young fighter. The adoption of a regulatory document determined the new course, the nature of the Armed Forces of Kazakhstan.
Directions Of Defense Innovation Of the Armed Forces Of the Republic Of Korea
Authors:   Hankuk University, Chul Кim Кyu
Published: October 2022

In this article, the author gives a brief overview of the state of the armed forces of the Republic of Korea. In particular, the defense innovation, which has recently been actively promoted by the Republic of Korea, is presented. The main contents of the Reform are also explained. The article is aimed at forming general ideas in the field of the country's security, as well as possible threats faced by the South Korean armed forces, counteraction measures and the buildup of Korean military power are presented. The study attempts to offer a productive and at the same time restrained approach to this issue by analyzing this political phenomenon, its problems and limitations. The study was based on data from international treaties, official agreements and declarations between governments, as well as official reactions and articles in the media.
Supporting Development of Tourism by Local Municipal Self-Governments within the Naturally Valuable Areas of the Lubelskie Voivodship
Authors: Guzal-Dec Danuta
Published: October 2022

The aim of the work is to diagnose the activity of local governments in supporting tourism development in naturally valuable areas of the Lubelskie Voivodship (Poland ). The study area consisted of 30 municipalities with the highest natural value in the Lubelskie Voivodship selected for the study based on the value of the indicator developed by D. Guzal-Dec in the study of the natural value of rural and urban-rural communes within the Lubelskie Voivodship. A questionnaire interview was used for the diagnostic purposes of the survey. Interviews were completed in 2013. The research material comprised 30 interviews with mayors and staff dealing with environmental issues in municipal offices. Websites of the surveyed communes were an important source of information. In the surveyed group, approximately 75% of the authorities declared their preference for tourism as the main direction of development of their commune. Detailed analysis of the use of various instruments of support lead to the conclusion that about 50% of them actively support tourism, of which about 30% have a planned policy manifested in a comprehensive application of the instruments of support. It seems, therefore, that strategies of cooperation for the development of tourism should be systematically and rationally utilized, especially in communities with high natural potential and less favorable non-natural conditions for tourism development.
Residential Real Estate Market in the Context of Local and Regional Development
Authors: Myna Artur
Published: October 2022

The aim of the work is to present the relationship between the development of residential real estate markets and local and regional development. It was found that the number of completed dwellings is strongly connected with the value of transactions on residential property markets in cities of over 200 000 inhabitants (confirmation of the theory of the residential real estate market as a “growth machine”). The value of transactions on the residential real estate market in these big cities proved to be strongly correlated with the number of natural persons performing economic activity and the share of persons working in the service sector in voivodships which would indicate regional development. Along with the increase in transactions on the residential real estate market, the demand for construction and renovation of flats and houses increases, as well as for works that cause an increase in the utility value of the property: finishing works, production and assembly of fences, hardening of the area or setting up gardens. The question arises as to whether natural persons performing economic activity do such works mainly in cities with more than 200 000 inhabitants and in suburbanization areas surrounding them (the hypothesis of local development), or the external effects of real estate markets as a “growth machine” have a supralocal range, somehow “leaking” beyond the areas of large cities and suburbanization zones (the hypothesis of regional development). Therefore, in-depth surveys are necessary.
Innowacyjność gospodarki a poziom życia mieszkańców państw Unii Europejskiej
Authors: Migała-Warchoł Aldona , Sobolewski Marek
Published: October 2022

W roku 2000 w tzw. Strategii Lizbońskiej Unia Europejska próbowała „zadekretować” innowacyjność, która miała być głównym panaceum na kryzysy gospodarcze i społeczne XXI wieku. Jednakże w nowej strategii „Europa 2020” zrezygnowano z nacisku na „innowacyjność dla innowacyjności”, próbując powiązać unowocześnianie gospodarki z efektami społecznymi. W tym kontekście zasadne wydaje się zbadanie zależności wybranych miar poziomu życia mieszkańców od poziomu innowacyjności gospodarki w obrębie państw Unii Europejskiej. Stanowi to główny cel poniższego artykułu. Analizą objęto dane dotyczące wskaźników innowacyjności gospodarek państw unijnych w 2015 roku oraz wybrane cechy odzwierciedlające pewne aspekty poziomu życia mieszkańców w tym samym okresie. W obliczeniach uwzględniono dodatkowo podział względem sytuacji geopolitycznej przed 1989 rokiem, bowiem mimo upływu ponad 25 lat, poziom rozwoju państw postkomunistycznych jest ciągle niższy niż pozostałych państw europejskich. Podstawową metodą statystyczną była analiza korelacji rang Spearmana. Z uzyskanych wyników można wysnuć wnioski o co najwyżej przeciętnej korelacji wskaźników innowacyjności z poziomem życia mieszkańców państw unijnych. Analizowane zależności były wyraźnie słabsze w grupie państw postkomunistycznych.
Regional Diversification of Saturation of the Housing Stock. Poland against the Background of Europe
Authors: Łaszek Jacek , Olszewski Krzysztof , Waszczuk Joanna
Published: October 2022

The aim of the article is to present the differences in saturation of the housing stock and its availability in Poland as well as in European Union countries and its influence on house prices and the economy. Regions which are characterized by a housing shortage will be separated. The analysis takes into account the differences in the level of wealth of the inhabitants and the scale of urbanization of individual states. The implications of social and economic imperfections in the functioning of the housing market, and in particular the price volatility of housing, have also been addressed. In addition, the quantitative and qualitative differences in the housing stock, which reduce the effective stock of available housing, are highlighted. In the case of Poland, only in Warsaw and Łódź does housing saturation correspond to that of the “old” EU. This article is divided into 5 parts. After an introduction to the subject, the second section deals with the issues of structural, long-term imbalances of demand and supply in the European housing market and its consequences. In the third section, the housing situation in the EU is presented. In the fourth part, the regional diversification in the housing stock in Poland is discussed. Section five consists of conclusions and a summary of the analysis.
An Attempt of Delimitation of Polish Metropolitan Areas by Discriminant Analysis
Authors: Zaród Jadwiga
Published: October 2022

The purpose of this article is a division of Poland into areas with different economic and social conditions and the identification of the areas which may aspire to the name of metropolis. Initial division of Polish territorial units was made on the basis of statistical data on the labor market, wages, public utilities, education, health care, environment, culture, industry and construction. These data were subjected to standardization and were verified as to whether represent a normal distribution. Then the discriminatory power of the variables were examined and parameters of the linear discriminant function were estimated. The highest average value of the discriminant function indicates the area most developed in terms of the examined features. Territorial units that belong to this complex are metropolises or aspire to being them. For each area, the classification functions were estimated and on their basis the final division was made. The allocation to the sub-region was mainly determined by variables such as density of population, unemployment rate, average flat surface and the number of entrepreneurs. In the first group are territorial units that belong already to the metropolitan areas. Subsequent numbers indicate areas with increasingly less economic and social development.