bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in life satisfaction during the transition to retirement: findings from the FIREA cohort study
Authors: Prakash K. C. , Virtanen Marianna , Törmälehto Soili , Myllyntausta Saana , Pentti Jaana , Vahtera Jussi , Stenholm Sari
Published: November 2022

Life satisfaction is an essential construct of well-being that is tied to behavioral, emotional, social and psychological outcomes. This study aimed to examine changes in total and domain-specific life satisfaction during the retirement transition and additionally examine whether those changes differ by gender, occupation, health and spousal working status. Aging public sector employees (n = 3543) from the Finnish Retirement and Aging Study cohort study were followed up annually before and after retirement. Total life satisfaction score (range 4–20) was computed by summing up the responses in four domains (interestingness, happiness, easiness and togetherness). The mean and mean change estimates and their 95% CI were calculated by using the linear regression models with generalized estimating equations, adjusted for age, gender, occupation, health and marital status. Total life satisfaction score improved among the entire study population during the retirement transition and remained stable thereafter. The improvement was greater among women versus men (gender * time interaction p = 0.004), among those with suboptimal health before retirement vs. those who had good (health * time p < 0.0001) and those who had no spouse vs. those who had a retired or working spouse (spousal-status * time p < 0.0001). In case of domain-specific life satisfaction scores, the greatest improvement was observed in the easiness domain. Life satisfaction improves during the retirement transition period, especially among women, those with suboptimal health and those living without a spouse. The improvement was considerably greater in the easiness domain than any other domains. Life satisfaction remained improved and stable during the post-retirement period.
Adapting emerging digital communication technologies for resilience: evidence from Nigerian SMEs
Authors: Ashiru Folajimi , Nakpodia Franklin , You Jacqueline J
Published: November 2022

Drawing on the Diffusion of Innovation Theory, this study explores how emerging digital communication technologies (EDCT) affected SMEs’ resilience during the COVID-19 pandemic. We employed an inductive and qualitative approach to investigate 42 SME operators in a weak institutional developing country—Nigeria. Our findings show that EDCT played a critical role in activating SMEs’ resilience during the crisis through four drivers: facilitating connections and bonding with staff, clients, and suppliers; enabling collaborations; activating process diversification; and enhancing supply chain flexibility. Furthermore, we highlight the distinct ability of Nigerian SMEs to buffer themselves against misinformation arising from the use of EDCT. This study sheds light on an EDCT Diffusion Model for resilience.
RETRACTED ARTICLE: Changes in management shape the spatial ecology of wild ponies in relation to habitat conservation
Authors: Lagos Laura , Fagúndez Jaime
Published: November 2022

Large herbivores are key regulators of open habitats across the world. Free roaming ponies have a prominent ecological role in many Atlantic landscapes, where different habitats with conservation interest are linked to ponies’ occurrence. The traditional management of wild ponies, which implies minimum human intervention, is declining in Galicia, NW Spain. Changes in the management regimes include the confinement of ponies in fenced areas, the use of improved pastures (IPs) and rotation between fields. Indirect effects of these changes are expected on the ecological condition of important habitats for conservation such as dry and wet heathlands and bogs. We studied social structure, spatial ecology and habitat use in 29 mares fitted with global positioning system (GPS) collars and field observations in two areas of Galicia dominated by wet heaths and blanket bogs (Xistral), and dry heaths (Sabucedo). We used spatial location and field observations to identify each band, and calculated band size, sex ratio, home range (HR) and core areas size and overlap, and habitat use. We addressed differences and adjusted Generalized Linear Models (GLMs) for these variables as functions of the type of management: free roaming vs rotation, use of IPs, fencing, and available ranging area. Larger bands were found in smaller commons, fenced and with rotation management. Home ranges, but not core area, varied as a function of the available ranging area. Bands overlap more on fenced areas with rotation management. Increasing management may concentrate grazing pressure by reducing HR and increasing bands overlapping areas, and this may have a long-term effect on habitat quality and conservation.
Circadian rhythm disrupting behaviours and cancer outcomes in breast cancer survivors: a systematic review
Authors: D’cunha Kelly , Park Yikyung , Protani Melinda M. , Reeves Marina M.
Published: November 2022

Purpose

Circadian rhythm disruptors (e.g., night-shift work) are risk factors for breast cancer, however studies on their association with prognosis is limited. A small but growing body of research suggests that altered sleep patterns and eating behaviours are potential mechanistic links between circadian rhythm disruptors and breast cancer. We therefore systematically summarised literature examining the influence of circadian rhythm disrupting behaviours on cancer outcomes in women with breast cancer.

Methods

A systematic search of five databases from inception to January 2021 was conducted. Original research published in English, assessing the relationship between post-diagnosis sleep patters and eating behaviours, and breast cancer outcomes were considered. Risk of bias was assessed using the Newcastle–Ottawa Assessment Scale for Cohort Studies.

Results

Eight studies published original evidence addressing sleep duration and/or quality (k = 7) and, eating time and frequency (k = 1). Longer sleep duration (≥ 9 h versus [referent range] 6-8 h) was consistently associated with increased risk of all outcomes of interest (HR range: 1.37–2.33). There was limited evidence to suggest that measures of better sleep quality are associated with lower risk of all-cause mortality (HR range: 0.29-0.97). Shorter nightly fasting duration (< 13 h versus ≥ 13 h) was associated with higher risk of all breast cancer outcomes (HR range: 1.21–1.36).

Conclusion

Our review suggests that circadian rhythm disrupting behaviours may influence cancer outcomes in women with breast cancer. While causality remains unclear, to further understand these associations future research directions have been identified. Additional well-designed studies, examining other exposures (e.g., light exposure, temporal eating patterns), biomarkers, and patient-reported outcomes, in diverse populations (e.g., breast cancer subtype-specific, socio-demographic diversity) are warranted.
Reasons for Meaningful Human Control
Authors: Veluwenkamp Herman
Published: November 2022

”Meaningful human control” is a term invented in the political and legal debate on autonomous weapons system, but it is nowadays also used in many other contexts. It is supposed to specify conditions under which an artificial system is under the right kind of control to avoid responsibility gaps: that is, situations in which no moral agent is responsible. Santoni de Sio and Van den Hoven have recently suggested a framework that can be used by system designers to operationalize this kind of control. It is the purpose of this paper to facilitate further operationalization of ”meaningful human control”.

This paper consists of two parts. In the first part I resolve an ambiguity that plagues current operationalizations of MHC. One of the design conditions says that the system should track the reasons of the relevant agents. This condition is ambiguous between the kind of reasons involved. On one interpretation it says that a system should track motivating reasons, while it is concerned with normative reasons on the other. Current participants in the debate interpret the framework as being concerned with (something in the vicinity of) motivating reasons. I argue against this interpretation by showing that meaningful human control requires that a system tracks normative reasons. Moreover, I maintain that an operationalization of meaningful human control that fails to track the right kind of reasons is morally problematic.

When this is properly understood, it can be shown that the framework of MHC is committed to the agent-relativity of reasons. More precisely, I argue in the second part of this paper that if the tracking condition of MHC plays an important role in responsibility attribution (as the proponents of the view maintain), then the framework is incompatible with first-order normative theories that hold that normative reasons are agent-neutral (such as many versions of consequentialism). In the final section I present three ways forward for the proponent of MHC as reason-responsiveness.
What drives conditional cooperation in public good games?
Authors: Katuščák Peter , Miklánek Tomáš
Published: November 2022

Extensive experimental research on public good games documents that many subjects are “conditional cooperators” in that they positively correlate their contribution with (their belief about) contributions of other subjects in their peer group. The goal of our study is to shed light on what preference and decision-making patterns drive this observed regularity. We consider reciprocity, conformity, inequality aversion and residual factors, such as confusion and anchoring, as potential explanations. Effects of these drivers are separated by varying how others’ contributions are determined and the informational content of the conditioning variable across treatments. Assuming additive separability of the effects of the four drivers, we find that, of the average conditionally cooperative behavior, at least 40 percent is driven by residual factors. For the remainder, most is accounted for by inequality aversion, some by conformity and very little by reciprocity. These findings carry an important message for how to interpret conditional cooperation observed in the lab. We also discuss what these findings mean for understanding conditional cooperation in fundraising applications in the field.
A cross-country configurational approach to international academic mobility: exploring mobility effects on academics’ career progression in EU countries
Authors: Bojica Ana María , Olmos-Peñuela Julia , Alegre Joaquín
Published: November 2022

This study takes a novel perspective on mobility as career script compliance to explore the factors that might influence how mobile academics in a country perceive the impact of international mobility on their overall academic career progression and job options. We conduct a country-level qualitative comparative analysis on a sample of 24 European Union (EU) countries, based on data from European Commission’s MORE3 indicator tool. We find that these perceptions about the impact are shaped by the dominant patterns of mobility in that country, and the general perception of academics in that particular country that international mobility is rewarded in the institutional promotion schemes. This study introduces new explanatory factors for the career script for international mobility. In so doing, we provide a richer understanding of how countries might influence academics’ mobility, which sheds light on previous inconclusive empirical evidence linking international mobility and academics’ careers. Our findings have implications for the policy design of international mobility and open up new lines of inquiry for cross-country comparisons.
One-dioptre toric IOL versus spherical IOL in eyes with low preoperative corneal astigmatism
Authors: Bellucci Carlo , Panico Angela , Tedesco Salvatore A. , Carta Arturo , Gandolfi Stefano , Bellucci Roberto , Mora Paolo
Published: November 2022

Purpose

To investigate the advantages/disadvantages of a 1.0 D toric IOL vs spherical IOL after regular phacoemulsification in eyes with preoperative astigmatism ≤ 1 D.

Methods

Retrospective comparative series involving pseudophakic eyes with preoperative topographic astigmatism ≤ 1.0 D implanted either with monofocal 1.0 D Toric IOL (T-group), or with spherical IOL (S-group). The postoperative refractive astigmatism (PRA, i.e. surgically induced + corneal) was the main outcome; also considered in the analyses were the uncorrected and best-corrected distance visual acuity (VA). The data were referred to the last postoperative follow-up visit, 2 to 4 months after surgery.

Results

A total of 60 eyes were included: 30 in the T-group and 30 in the S-group, matched for patient’s age, laterality, and axial length. Before surgery, the mean corneal astigmatism was 0.62 ± 0.39 D in the T-group and 0.54 ± 0.33 D in the S-group (p = 0.4). In the S-group, PRA was 0.73 ± 0.37 D, higher than the corresponding preoperative corneal astigmatism (p = 0.040). In the T-group, PRA was 0.58 ± 0.31 D; the variation was not statistically significant. Uncorrected VA was significantly better in the T-group vs the S-group (p = 0.007), and the best-corrected VA was comparable in the two groups.

Conclusion

The present study indicated that in eyes with very low preoperative astigmatism, 1.0 D toric IOLs were able to limit the increase of the PRA instead of those observed with the spherical IOLs. This could support the better uncorrected VA recorded in the T-group.
Reoperations for complications within 90 days after gel stent implantation or trabeculectomy
Authors: Cutolo Carlo A. , Bonzano Chiara , Catti Carlo , Pizzorno Chiara , Bagnis Alessandro , Traverso Carlo E. , Iester Michele
Published: November 2022

Purpose

To describe reoperations in the operating room for complications that occurred within the first 90 days after gel stent implantation or trabeculectomy at a single institution over 5 years.

Methods

In this retrospective chart review, patients who have undergone gel stent implantation with mitomycin C (MMC) or trabeculectomy with MMC were enrolled. Postoperative complications that required reoperations within the first 90 days were evaluated.

Results

A total of 510 surgeries were performed on 392 patients over a 57-month period by 2 glaucoma surgeons. Of these, 284 were gel stent implantation, and 226 were trabeculectomy. Combined phacoemulsification was performed in 52/284 (18.3%) in the gel stent group and in 26/226 (11.5%) of eyes in the trabeculectomy group (p = 0.03). Reoperations took place in 13/510 (2.5%) eyes, including 4/284 (1.4%) in the gel stent group, 9/226 (4.0%) in the trabeculectomy group (p = 0.07). In the gel stent group, indications for reoperation were bleb failure (2), suprachoroidal hemorrhage (1), bullous keratopathy (1). In the trabeculectomy group, indications for reoperation were bleb failure (3), overfiltration (2), persistent wound leak (2), aqueous misdirection (2).

Conclusions

The rates of reoperation for early postoperative complications after gel stent or trabeculectomy was low and comparable with previous studies. A slightly higher number of reoperations within 90 days was observed in the trabeculectomy group than the gel stent group despite the more significant number of combined procedures in the latter group. Bleb failure was the most common indications for reoperation in both groups. Excessive outflow was a cause of reoperation mostly in the trabeculectomy group.
Seasonal and spatial compositional variation of the red algae Mastocarpus stellatus from the Northern coast of Portugal
Authors: Sanz Vanesa , Torres María Dolores , Domínguez Herminia , Pinto Isabel Sousa , Costa Isabel , Guedes A. Catarina
Published: November 2022

This study focusses on the valorization of the red seaweed Mastocarpus stellatus, collected in the Northern coast of Portugal, as a natural source of high value compounds due to its beneficial properties. An annual monitoring of the seaweed was performed by determining its lipids, ash, carbohydrates, phycobiliproteins, total phenolic compounds, antioxidant capacity and carrageenan from three different rocky shores located in the north of Portugal. The results showed a seasonal and spatial variability of the studied compounds between October 2018 and September 2019 depending on the climatic variables of temperature, precipitation, and solar radiation. The most productive season coincided with the warmest months, except for carbohydrates and phycobiliproteins, which were promoted in the colder season. The spatial variation also could be explained by the proximity to water channel discharges at the sampling sites. Complementary studies on the carrageenan fraction were conducted in one of the shores due to the high biopolymer content, to determine their carrageenan proportion between the summer and winter period and establish their rheological capabilities for the formulation of gelling matrices. The extracted biopolymers exhibited typical structural and viscoelastic characteristics of kappa/iota-hybrid carrageenans, suggesting notably differences depending on the harvest season, which is critically relevant to define future applications.
The heterogeneous nature of mechanically accelerated grain growth
Authors: Chen Elton Y. , Hamilton Parker , Boyce Brad L. , Dingreville Rémi
Published: November 2022

While grain growth is traditionally viewed as a purely thermally driven process, nanocrystalline metals can undergo grain growth under mechanical loads, even at room temperature. We performed a detailed atomistic study of the heterogeneous nature of mechanically accelerated grain growth in a polycrystalline Pt nanowire. Using molecular dynamics simulations, we compared the grain-growth behavior of individual grains during tensile and shear cyclic loading, for three different equivalent strain levels, and at two temperatures. Pure thermal grain growth with no mechanical loading provided a baseline reference case. On average, grains that were already susceptible to thermal grain growth were stimulated to grow faster with mechanical loading, as expected. However, when analyzed on a grain-by-grain basis, the results were far more complex: grains that grew fastest under one stimuli were less accelerated under other stimuli. Even when the magnitude of loading changed, the relative growth of individual grains was distorted. We interpret this complexity from the perspective of superimposed growth mechanisms.
Ethical Conflicts in Healthcare Chaplaincy: Results of an Exploratory Survey Among Protestant Chaplains in Switzerland, Germany, and Austria
Authors: Farr Sebastian , Roser Traugott , Coors Michael
Published: November 2022

The paper reports the results of an exploratory online survey among German, Austrian, and Swiss hospital chaplains (n = 158, response rate 17%) to identify the ethical conflicts they encounter in their work. Respondents indicated that questions surrounding end-of-life care are predominant among the conflicts faced. Chaplains get involved with these conflicts most often through the patients themselves or through nursing staff. Most encounters occur during pastoral care visits rather than in structured forms of ethics consultation such as clinical ethics committees. The results add to the ongoing discussion of chaplains as agents in ethics consultation within healthcare systems as well as their specific role and contribution.
Advancements in the fabrication and characterization of actinide targets for superheavy element production
Authors: Düllmann Ch. E. , Artes E. , Dragoun A. , Haas R. , Jäger E. , Kindler B. , Lommel B. , Mangold K.-M. , Meyer C.-C. , Mokry C. , Munnik F. , Rapps M. , Renisch D. , Runke J. , Seibert A. , Stöckl M. , Thörle-Pospiech P. , Trautmann C. , Trautmann N. , Yakushev A.
Published: November 2022

The heaviest elements can exclusively be produced in actinide-target based nuclear fusion reactions with intense heavy-ion beams. Ever more powerful accelerators deliver beams of continuously increasing intensity, which brings targets of current technology to their limits and beyond. We motivate efforts to produce targets with improved properties, which calls for a better understanding of targets produced by molecular plating, the current standard method. Complementary analytical methods will help shedding more light on their chemical and physical changes in the beam. Special emphasis is devoted to the aspect of the optimum target thickness and the choice of the backing material.
Applications of hydrogels with fire retardant properties—a review
Authors: Mastalska-Popławska Joanna , Wójcik Łukasz , Izak Piotr
Published: November 2022

Due to their unique properties, hydrogels can be used in many areas of life and science. The main purpose of this work was to present the possibility of using hydrogels as a kind of fire retardant material itself and as a medium in fire retardant materials used, among others, as the extinguishing agents for fires and the suppression agents for the self-ignition of coal in mines (where their low viscosity and high ability to penetration of the protected material is used), protective layers in fabrics and the so-called robot skin (most often applied in the layer-by-layer system), filling in the fire retardant window panels (mostly hybrid hydrogels or hydrogel copolymers are used) and protective emulsions of the wooden elements used in construction and furniture joinery (mainly in combination with silicate and phosphate derivatives). In the presented applications, hydrogels can be used alone, e.g. due to the large water capacity and at the same time the possibility of dilution, or in combination with fire retardants, what very often allows for the multiplication of the extinguishing or fire retardant effect. Due to the multitude of available studies and the speed of scientific development, this review is focused mainly on publications written after 2015.
Dispersion compensation using cascaded apodized CFBGs under MTDM transmission technique: Enhanced system performance
Authors: Mustafa Fathy M. , Mohamed Asmaa , Khalaf Ashraf A. M. , Sayed Ahmed F. , Aly Moustafa H.
Published: November 2022

This study focuses on compensating chromatic dispersion affecting the propagated signal in a standard single mode optical fibers (SSMFs). We propose a model that consists of an identical four stages cascaded linear chirped apodized fiber Bragg gratings (CFBGs) in a post-compensation scheme under Maximum Time Division Multiplexing (MTDM) technique. MTDM is free of the limitations resulting from the fiber nonlinear effects. It, thus, effectively utilizes optical wavelength and operating in various network of different distances and capacities. Therefore, MTDM is designed to be used in the high-capacity and high-speed transmission systems. The evaluation of the proposed model performance is performed through a comparative study using different connections and the most common apodization functions. This comparative study includes three cases based on the used connection scheme. A 10 Gbps Wavelength Division Multiplexing (WDM) 70 km link is simulated under ordinary operating parameters. Optisystem 7.0 is used for the simulation and evaluation process, in terms of two metrics which are quality factor (Q-factor) and bit error rate (BER). In the pre-compensation scheme, the highest results are: Q-factor = 7.664 and BER = 8.99 × 10–15, using the raised cosine apodization function. Using the raised sine apodization in the post-compensation connection realizes the best performance: Q-factor = 8.58 and BER = 4.77 × 10–18. In the symmetrical-compensation scheme and using the raised sine apodization, the proposed model attains the highest Results: Q-factor = 7.49 and BER = 3.53 × 10–14. The proposed model achieves at least 92.6% improvement in BER and 3.75% in Q-factor over the related works. The study is a simulation work and is performed through Optisystem ver. 7.
Preclinical Considerations for Long-acting Delivery of Tenofovir Alafenamide from Subdermal Implants for HIV Pre-exposure Prophylaxis
Authors: Gunawardana Manjula , Remedios-Chan Mariana , Sanchez Debbie , Fanter Rob , Webster Simon , Webster Paul , Moss John A. , Trinh MyMy , Beliveau Martin , Ramirez Christina M. , Marzinke Mark A. , Kuo Joseph , Gallay Philippe A. , Baum Marc M.
Published: November 2022

Purpose

Long-acting formulations of the potent antiretroviral prodrug tenofovir alafenamide (TAF) hold potential as biomedical HIV prevention modalities. Here, we present a rigorous comparison of three animal models, C57BL/6 J mice, beagle dogs, and merino sheep for evaluating TAF implant pharmacokinetics (PKs).

Methods

Implants delivering TAF over a wide range of controlled release rates were tested in vitro and in mice and dogs. Our existing PK model, supported by an intravenous (IV) dosing dog study, was adapted to analyze mechanistic aspects underlying implant TAF delivery.

Results

TAF in vitro release in the 0.13 to 9.8 mg d−1 range with zero order kinetics were attained. Implants with equivalent fabrication parameters released TAF in mice and sheep at rates that were not statistically different, but were 3 times higher in dogs. When two implants were placed in the same subcutaneous pocket, a two-week creep to Cmax was observed in dogs for systemic drug and metabolite concentrations, but not in mice. Co-modeling IV and TAF implant PK data in dogs led to an apparent TAF bioavailability of 9.6 in the single implant groups (compared to the IV group), but only 1.5 when two implants were placed in the same subcutaneous pocket.

Conclusions

Based on the current results, we recommend using mice and sheep, with macaques as a complementary species, for preclinical TAF implant evaluation with the caveat that our observations may be specific to the implant technology used here. Our report provides fundamental, translatable insights into multispecies TAF delivery via long-acting implants.
Commentary for Special Issue on Using Baseline Target Moderation to Assess Variation in Prevention Impact: When (and How) to Revise Our Programs
Authors: Gardner Frances
Published: November 2022

Developing a better understanding of sources and mechanisms of heterogeneity is a key route to improving outcomes and targeting of preventive interventions. This commentary attempts to draw together findings from eight intervention trials in this special issue, each exploring baseline target moderation (BTM) or baseline target moderated mediation (BTMM). It considers their implications for prevention research and program design, particularly the question of whether they can help us to revise or adapt interventions. The studies cover a range of interventions, targets, and contexts, including parenting, couple, and CBT interventions, for depression, anxiety, conduct problems, or obesity. Some important findings stand out. Where studies found moderator effects, they tended to operate in a “compensatory” fashion, such that greater benefit was found in higher risk groups, suggesting that closer targeting might be warranted. It was rare for harmful effects to be detected for any subgroups. In other respects, patterns of BTM/BTMM findings were quite mixed across studies, suggesting it would be premature to change our interventions based on these trials. Implications of the findings for equity, for “slimming down” and scaling up interventions, and for research are discussed, including the need to combine BTMM with intervention component research, and to accumulate a more robust body of evidence by pooling data across trials.
Transitions in depression: if, how, and when depressive symptoms return during and after discontinuing antidepressants
Authors: Smit Arnout C. , Snippe Evelien , Bringmann Laura F. , Hoenders H. J. Rogier , Wichers Marieke
Published: November 2022

Purpose

The aim of the current study is to provide insight into if, how, and when meaningful changes occur in individual patients who discontinue antidepressant medication. Agreement between macro-level quantitative symptom data, qualitative ratings, and micro-level Ecological Momentary Assessments is examined.

Methods

During and shortly after antidepressant discontinuation, depressive symptoms and ‘feeling down’ were measured in 56 participants, using the SCL-90 depression subscale weekly (macro-level) for 6 months, and 5 Ecological Momentary Assessments daily (micro-level) for 4 months (30.404 quantitative measurements in total). Qualitative information was also obtained, providing additional information to verify that changes were clinically meaningful.

Results

At the macro-level, an increase in depressive symptoms was found in 58.9% of participants that (a) was statistically reliable, (b) persisted for 3 weeks and/or required intervention, and (c) was clinically meaningful to patients. Of these increases, 30.3% happened suddenly, 42.4% gradually, and for 27.3% criteria were inconclusive. Quantitative and qualitative criteria showed a very high agreement (Cohen’s κ = 0.85) regarding if a participant experienced a recurrence of depression, but a moderate agreement (Cohen’s κ = 0.49) regarding how that change occurred. At the micro-level, 41.1% of participants experienced only sudden increases in depressed mood, 12.5% only gradual, 30.4% experienced both types of increase, and 16.1% neither.

Conclusion

Meaningful change is common in patients discontinuing antidepressants, and there is substantial heterogeneity in how and when these changes occur. Depressive symptom change at the macro-level is not the same as depressive symptom change at the micro-level.
Hypothetical versus experienced health state valuation: a qualitative study of adult general public views and preferences
Authors: Powell Philip A. , Karimi Milad , Rowen Donna , Devlin Nancy , van Hout Ben , Brazier John E.
Published: November 2022

Objectives

Responses from hypothetical and experienced valuation tasks of health-related quality of life differ, yet there is limited understanding of why these differences exist, what members of the public think about them, and acceptable resolutions. This study explores public understanding of, opinions on, and potential solutions to differences between hypothetical versus experienced responses, in the context of allocating health resources.

Methods

Six focus groups with 30 members of the UK adult public were conducted, transcribed verbatim, and analysed using framework analysis. Participants self-completed the EQ-5D-5L, before reporting the expected consequences of being in two hypothetical EQ-5D-5L health states for ten years. Second, participants were presented with prior results on the same task from a public (hypothetical) and patient (experienced) sample. Third, a semi-structured discussion explored participants’: (1) understanding, (2) opinions, and (3) potential resolutions.

Results

Twenty themes emerged, clustered by the three discussion points. Most participants found imagining the health states difficult without experience, with those aligned to mental health harder to understand. Participants were surprised that health resource allocation was based on hypothetical responses. They viewed experienced responses as more accurate, but noted potential biases. Participants were in favour of better informing, but not influencing the public. Other solutions included incorporating other perspectives (e.g., carers) or combining/weighting responses.

Conclusion

Members of the UK public appear intuitively not to support using potentially uninformed public values to hypothetical health states in the context of health resource allocation. Acceptable solutions involve recruiting people with greater experience, including other/combinations of views, or better informing respondents.
Continuity correction: on the pricing of discrete double barrier options
Authors: Luo Sheng-Feng , Wong Hsin-Chieh
Published: November 2022

This article deals with the pricing of double-barrier options monitored discretely. A continuity correction method is established to provide an analytical approximation for the price of such discrete options under the Black–Scholes model. We achieve this by applying the smooth-fit principle simultaneously to the two flat boundaries (barriers) associated. The resulting correction form still involves adjustments in the levels of barriers, but the amounts adjusted can be different for different boundaries. More interestingly, the shift for each boundary can also be in different directions, which depends largely on the position of the current level relative to the two boundaries. Numerical examples are provided as well which support our theoretical achievements.
‘Getting the Right Nutrients to Those Who Need Them Most’: towards nutrition-sensitive governance of fisheries in the Global South
Authors: Allegretti Antonio , Hicks Christina C.
Published: November 2022

Here we propose a framework and agenda for nutrition-sensitive governance (NSG) of fisheries that rethink dominant paradigms of fisheries governance and propose measures to incorporate nutrition-related objectives into fisheries governance. Fish, rich in micronutrients, have potential for improving the nutritional status of coastal and riparian communities, particularly in the Global South where inadequate nutrition is prevalent. Yet, the potential for fish to alleviate malnutrition remains limited to policy documents and high-level government commitments. We propose an agenda for NSG in the Global South grounded in three main pillars: 1-extending the boundaries of fisheries governance, 2-integrating multiple forms of knowledge, and 3-prioritizing domestic and local needs; each of these pillars links different levels of governance starting at the level of conceptualization and images connected to what fisheries are and should do, to a more policy-oriented level with hands-on recommendations, through an intermediate level that links the two. Overall, we propose a concept and agenda for NSG grounded in a human-centred approach to fisheries governance with social sciences playing a crucial role in unearthing the nodes of power that limit access and agency of poor and vulnerable (fishing) communities to the nutritional benefits of fish. In doing so, we critically analyze dominant fisheries governance agendas (‘Blue Economy’, ‘Blue Growth’) through the lens of food and nutrition security and anchor these debates to the objective of getting the right nutrients to those who need them most.
Animal Pose Tracking: 3D Multimodal Dataset and Token-based Pose Optimization
Authors: Patel Mahir , Gu Yiwen , Carstensen Lucas C. , Hasselmo Michael E. , Betke Margrit
Published: November 2022

Accurate tracking of the 3D pose of animals from video recordings is critical for many behavioral studies, yet there is a dearth of publicly available datasets that the computer vision community could use for model development. We here introduce the Rodent3D dataset that records animals exploring their environment and/or interacting with each other with multiple cameras and modalities (RGB, depth, thermal infrared). Rodent3D consists of 200 min of multimodal video recordings from up to three thermal and three RGB-D synchronized cameras (approximately 4 million frames). For the task of optimizing estimates of pose sequences provided by existing pose estimation methods, we provide a baseline model called OptiPose. While deep-learned attention mechanisms have been used for pose estimation in the past, with OptiPose, we propose a different way by representing 3D poses as tokens for which deep-learned context models pay attention to both spatial and temporal keypoint patterns. Our experiments show how OptiPose is highly robust to noise and occlusion and can be used to optimize pose sequences provided by state-of-the-art models for animal pose estimation.
Applicability and Extraction Characteristics of Aluminum Sulfate as Extractant of Harmful Heavy Metals for On-Site Treatment of Deep-Sea Mining Tailings
Authors: Lee Gaeun , Kim Kyoungrean
Published: November 2022

This research was focused on the eco-friendly treatment of deep-sea mining tailings in the sea areas and mainly dealt with evaluating the optimal conditions by comparing aluminum sulfate (AS), which had been proven recently to have an effect as a heavy metal extractant, with ethylenediaminetetraacetic acid (EDTA) in terms of environmental and economic feasibility. Harmful heavy metals in the manganese nodules (2%, w/v) were chemically washed by mixing with each EDTA and AS concentration for 16 elapsed times. Copper, zinc, nickel, and cadmium, which could have a fatal effect due to their high total content or high bioavailable content, were selected as the primary treatment target materials. The content of harmful heavy metals was 293.2 times more for nickel when compared with environmental standards of various countries. When 1% AS was used as the extractant, the removal efficiency of harmful heavy metals compared to the bioavailable content was 32.77% on average. It has been verified that multi-stage treatment could be necessary, and the short treatment time could be an important factor. Within a short elapsed time (3 h), the remediation efficiency of zinc and nickel under the 1% AS condition was higher than with 0.1 M EDTA. In terms of environmental and economic feasibility, it was verified that the use of 1% AS would be reasonable. The results of this research could be valuably applied to process design and optimization as basic data presented before the development of remediation technologies in the future.

Graphical Abstract
Characterization of thermo/halo stable cellulase produced from halophilic Virgibacillus salarius BM-02 using non-pretreated biomass
Authors: Yousef Naeima M. H. , Mawad Asmaa M. M.
Published: November 2022

The production of extremozymes from halophilic bacteria has increased significantly due to their stability and efficiency in catalyzing a reaction, as well as their capacity to display optimum activity at various salt concentrations. In the current study, the halophilic bacteriumVirgibacillus salariusstrain BM-02 could utilize many non-pretreated substrates including cellulose, corn stover, sugarcane bagasse and wheat bran as a sole carbon source. However, wheat bran was the best substrate for achieving optimum saccharification yield (90.1%). The partially purified cellulase was active and stable at a wide range of pH (5–8) with residual activities > 58%. Moreover, it was stable at 5–12% of NaCl. Metal ions have a variable impact on the activity of partially purified cellulase however, Fe+3exhibited the highest increase in the cellulase activity. The enzyme exhibited a thermal stability at 40, 50 and 60 °C with half-lives of 1049.50, 168.14 and 163.5 min, respectively. The value of Vmaxwas 22.27 U/mL while Km was 2.1 mM. The activation energy of denaturation Ed69.81 kJ/mol, the enthalpy values (ΔHd) were positive, and the entropy values (ΔS) were negative. Therefore,V. Salariusis recommended as a novel promising halophilic extremozyme producer and agricultural waste remover in the bio-industrial applications.

Graphical abstract
Historical Roots and Seminal Papers of Quantum Technology 2.0
Authors: Scheidsteger Thomas , Haunschild Robin , Ettl Christoph
Published: November 2022

We present a historical study of Quantum Technology 2.0 using more than 66,000 papers from 1980 to 2020 that had been assigned to four subfields. We applied the method reference publication year spectroscopy to respective publication sets of the subfields in order to identify their historical roots and seminal papers. We found 126 of them in total, 43 in quantum metrology and sensing, 46 in quantum communication and cryptography, 42 in quantum computing, and 33 in quantum information science–with a significant overlap between subfields–which are all discussed in their relevance for the respective subfield. We compared the subfields regarding their interrelationship and distinctiveness in terms of their most influential papers and were able to deduce a common core set of five seminal publications in all four subfields.
Contributions of healthier diets and agricultural productivity toward sustainability and climate goals in the United States
Authors: Wu Grace C. , Baker Justin S. , Wade Christopher M. , McCord Gordon C. , Fargione Joseph E. , Havlik Petr
Published: November 2022

Meeting ambitious climate targets will require deploying the full suite of mitigation options, including those that indirectly reduce greenhouse-gas (GHG) emissions. Healthy diets have sustainability co-benefits by directly reducing livestock emissions as well as indirectly reducing land use emissions. Increased crop productivity could indirectly avoid emissions by reducing cropland area. However, there is disagreement on the sustainability of proposed healthy U.S. diets and a lack of clarity on how long-term sustainability benefits may change in response to shifts in the livestock sector. Here, we explore the GHG emissions impacts of seven scenarios that vary U.S. crop yields and healthier diets in the U.S. and overseas. We also examine how impacts vary across assumptions of future ruminant livestock productivity and ruminant stocking density in the U.S. We employ two complementary land use models—the US FABLE Calculator, an agricultural and forestry sector accounting model with high agricultural commodity representation, and GLOBIOM, a spatially explicit partial equilibrium optimization model for global land use systems. Results suggest that healthier U.S. diets that follow the Dietary Guidelines for Americans reduce agricultural and land use greenhouse gas emissions by 25–57% (approx 120–310 MtCO2e/y) and pastureland area by 28–38%. The potential emissions and land sparing benefits of U.S. agricultural productivity growth are modest within the U.S. due to the increasing comparative advantage of U.S. crops. Our findings suggest that healthy U.S. diets can significantly contribute toward meeting U.S. long-term climate goals for the land use sectors.
Spatial Distribution of Dicrocoelium in the Himalayan Ranges: Potential Impacts of Ecological Niches and Climatic Variables
Authors: Khan Muhammad Asim , Afshan Kiran , Sargison Neil D. , Betson Martha , Firasat Sabika , Chaudhry Umer
Published: November 2022

Purpose

Dicrocoeliosis can be an important cause of production loss in ruminants due to the cost of liver condemnation at slaughter. The aim of the present study was to determine the prevalence of Dicrocoelium infection and to predict the ecological niches and climatic variables that support dicrocoeliosis in the Himalayan ranges of Pakistan.

Methods and Results

Dicrocoelium was detected in 33 of 381 liver samples and 238 of 6060 blood samples taken from sheep and goat herds in the area. The prevalence of dicrocoeliosis was higher in sheep than in goats and highest in females aged more than 3 years. An environmental risk map was created to predict active zones of transmission and showed the highest probability values in central parts of the Chitral district in the northwest of Pakistan. Climatic variables of the mean monthly diurnal temperature range (Bio2), annual precipitation (Bio12), and normalised difference vegetation index (NDVI) were found to be significantly (p < 0.05) associated with the presence of Dicrocoelium infection.

Conclusion

Together, the findings of this study demonstrate the most suitable ecological niches and climatic variables influencing the risk of dicrocoeliosis in the Himalayan ranges of Pakistan. The methods and results could be used as a reference to inform the control of dicrocoeliosis in the region.
The Identification of Human Translational Biomarkers of Neuropathic Pain and Cross-Species Validation Using an Animal Model
Authors: Young Bethan , Stephenson John , Islam Barira , Burke Nikita N. , Jennings Elaine M. , Finn David P. , McHugh Patrick C.
Published: November 2022

Neuropathic pain is a common chronic condition, which remains poorly understood. Many patients receiving treatment continue to experience severe pain, due to limited diagnostic/treatment management programmes. The development of objective clinical diagnostic/treatment strategies requires identification of robust biomarkers of neuropathic pain. To this end, we looked to identify biomarkers of chronic neuropathic pain by assessing gene expression profiles in an animal model of neuropathic pain, and differential gene expression in patients to determine the potential translatability. We demonstrated cross-species validation of several genes including those identified through bioinformatic analysis by assessing their expression in blood samples from neuropathic pain patients, according to conservative assessments of significance measured using Bonferroni-correctedp-values. These includeCASP5(p = 0.00226),CASP8(p = 0.00587),CASP9(p = 2.09 × 10−9),FPR2(p = 0.00278),SH3BGRL3(p = 0.00633), andTMEM88(p = 0.00038). A ROC analysis revealed several combinations of genes to show high levels of discriminatory power in the comparison of neuropathic pain patients and control participants, of which the combinationSH3BGRL3,TMEM88, andCASP9achieved the highest level (AUROC = 0.923). TheCASP9gene was found to be common in five combinations of three genes revealing the highest levels of discriminatory power. In contrast, the gene combinationPLAC8,ROMO1, andA3GALT2showed the highest levels of discriminatory power in the comparison of neuropathic pain and nociceptive pain (AUROC = 0.919), when patients were grouped by S-LANSS scores. Molecules that demonstrate an active role in neuropathic pain have the potential to be developed into a biological measure for objective diagnostic tests, or as novel drug targets for improved pain management.
An analysis of weight initialization methods in connection with different activation functions for feedforward neural networks
Authors: Wong Kit , Dornberger Rolf , Hanne Thomas
Published: November 2022

The selection of weight initialization in an artificial neural network is one of the key aspects and affects the learning speed, convergence rate and correctness of classification by an artificial neural network. In this paper, we investigate the effects of weight initialization in an artificial neural network. Nguyen-Widrow weight initialization, random initialization, and Xavier initialization method are paired with five different activation functions. This paper deals with a feedforward neural network, consisting of an input layer, a hidden layer, and an output layer. The paired combination of weight initialization methods with activation functions are examined and tested and compared based on their best achieved loss rate in training. This work aims to better understand how weight initialization methods in neural networks, in combination with activation functions, affect the learning speed in comparison after a fixed number of training epochs.
Immigrant Organizations and Labor Market Integration: The Case of Sweden
Authors: Sandberg Johan , Fredholm Axel , Frödin Olle
Published: November 2022

In line with recent trends in sociology of migration, the paper presents major research findings on Swedish immigrant organizations (SIOs) and their labor market integration activities. Analyses of engagement in these activities are particularly important as Sweden wrestles with significant problems of labor market marginalization, particularly among non-European migrants. Drawing on official data and interviews, we find surprisingly low incidence in direct labor market support but quite active indirect support. Our regression model shows significant correlation between region of origin and labor market activities, and further analyses using regional typologies indicate that SIOs’ activities are partly driven by members’ different modes of incorporation and relative integration, where Middle-Eastern SIOs stand out as particularly active. Our findings further indicate potential for scale-up of SIO-assistance in the Swedish Government’s efforts towards increased immigrant labor market integration.