bluuebunny/crossref_metadata_2025 huggingface dataset:
Temozolomide Alone or Combined with Capecitabine for the Treatment of Metastatic Neuroendocrine Neoplasia: A “Real-World” Data Analysis
Authors: Bongiovanni Alberto , Liverani Chiara , Foca Flavia , Fausti Valentina , Di Menna Giandomenico , Mercatali Laura , De Vita Alessandro , Riva Nada , Calpona Sebastiano , Miserocchi Giacomo , Spadazzi Chiara , Cocchi Claudia , Ibrahim Toni
Published: November 2020

Background: Neuroendocrine neoplasias (NENs) are a rare group of tumors with different prognosis and response to therapy. Their heterogeneity is dependent on the site of origin, morphology, and Ki67. Temozolomide (TEM) appears to be active in metastatic NENs (mNENs) but there is limited evidence about its efficacy in gastrointestinal NENs. We analyzed “real-world” data on the use of TEM alone or in association with capecitabine (CAPTEM) in patients with mNENs. Patients and Methods: One hundred consecutive patients with advanced NENs treated with TEM or CAPTEM between 2009 and 2019 were included. A pretreatment tumor growth rate (TGR0) was calculated. Overall survival (OS), progression-free survival (PFS), tolerance, objective response rate (ORR), and disease control rate (DCR) were analyzed. A propensity score analysis and inverse probability of treatment weights for Cox regression models were used. Results: TEM-based therapy was administered to 95 patients (26.3% CAPTEM and 83.7% TEM) with a median age of 59 years (range 26–85) years. ECOG performance status was 0–2. Carcinoid syndrome was reported in 12 (12.6%) patients. Twenty (21.1%) patients with grade (G) 3 neuroendocrine carcinoma (NEC) and 9 (9.4%) with G3 neuroendocrine tumors (NETs) were included in the analysis. Median PFS of the entire group was 10.4 months (95% confidence interval [CI]: 6.0–11.5). In multivariate analysis, a higher risk of progression was observed for NEC G3 patients (hazard ratio [HR] 2.70, 95% CI: 1.25–5.84) and for a TGR ≥19.55 (HR: 2.53, 95% CI: 1.45–4.40). Median OS was 23.4 months (95% CI: 17.0–29.0) and was similar in both treatment groups (23.9 vs. 20.5 months for TEM and CAPTEM, respectively, p = 0.585). In multivariate analysis, TGR ≥19.55 was associated with a higher risk of death (HR: 2.18, 95% CI: 1.16–4.11) than TGR <19.55, as was NEC G3 (HR: 2.42, 95% CI: 1.04–5.59) with respect to NETs. No differences in terms of mPFS or mOS were seen in relation to the primary site of disease. In the 86 patients evaluable for response, ORR was 44.1% and the DCR was 70.9%. Mild adverse events (grade I–II) included anemia, neutropenia, and headache. Rare cases of G 3 neutropenia and thrombocytopenia were recorded. Conclusions: TEM-based regimens are associated with a high DCR and a relatively tolerable toxicity profile in NENs of pancreatic, intestinal, and lung origin. Further investigation of these specific NETs is warranted in prospective clinical trials.
Early Recanalization With Alteplase in Stroke Because of Large Vessel Occlusion in the ESCAPE Trial
Authors: Ospel Johanna M. , Singh Nishita , Almekhlafi Mohammed A. , Menon Bijoy K. , Butt Asif , Poppe Alexandre Y. , Jadhav Ashutosh P. , Silver Frank L. , Shah Ruchir , Dowlatshahi Dar , O’Hare Alan M. , Demchuk Andrew M. , Goyal Mayank , Hill Michael D. ,   on behalf of the ESCAPE Trial Investigators
Published: November 2020

Background and Purpose:

Quantitating the effect of intravenous alteplase on the technical outcome of early recanalization of large vessel occlusions aids understanding. We report the prevalence of early recanalization in patients with stroke because of large vessel occlusion treated with and without intravenous alteplase and endovascular thrombectomy, and its association with clinical outcome.

Methods:

Patients with acute ischemic stroke with large vessel occlusion from the ESCAPE trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times Trial) were included in this post hoc analysis. Outcomes of interest were the prevalence of early recanalization (1) and good outcome (2), defined as modified Rankin Scale score of 0 to 2 at 90 days.

Results:

Among 147 patients who did not receive endovascular thrombectomy, early recanalization occurred in 4/30 (13.3%) patients without and 48/117 (41.0%) patients with intravenous alteplase (adjusted risk ratios, 3.2 [95% CI, 1.2–8.1]). Good outcome was achieved by 34/116 (29.3%) of patients who received intravenous alteplase versus 10/29 (34.5%) who did not receive alteplase (adjusted risk ratios, 1.0 [95% CI, 0.6–1.5) and by 20/52 (38.5%) patients with versus 24/93 (25.8%) without early recanalization (adjusted risk ratios, 1.9 [95% CI, 1.2–2.9]).

Conclusions:

Early recanalization was confirmed as a strong predictor of good outcome in patients who did not undergo endovascular thrombectomy and was improved with intravenous alteplase, yet a majority of patients (59.0%) did not achieve early reperfusion.

Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01778335.
Transdisciplinary Convergence: Intelligent Infrastructure for Sustainable Development
Authors: Shen Yi
Published: November 2020

The fast-developing intelligent infrastructure landscape catalyzes transformative new relationships of human, technology, and environment and requires new socio-technical configurations of information practice and knowledge work. With a focus on data as the source of intelligence, this paper aims to explore the shifting scenarios and indicative features of data science solutions for intelligent system applications and identify the evolving knowledge spaces and integrative learning practices in the “smart” landscape. It projects and discusses the democratization of data science platforms, the distribution of data intelligence on the edge, and the transition from vertical to horizontal data solutions in solving intelligent system problems. Through mapping the changing data research landscape, this work further reveals essential new roles of knowledge architects and social engineers in enabling dynamic data linking, interaction, and exploration for transdisciplinary data convergence.
The Role of the Right Hemisphere in Processing Phonetic Variability Between Talkers
Authors: Luthra Sahil
Published: November 2020

Neurobiological models of speech perception posit that both left and right posterior temporal brain regions are involved in the early auditory analysis of speech sounds. However, frank deficits in speech perception are not readily observed in individuals with right hemisphere damage. Instead, damage to the right hemisphere is often associated with impairments in vocal identity processing. Herein lies an apparent paradox: The mapping between acoustics and speech sound categories can vary substantially across talkers, so why might right hemisphere damage selectively impair vocal identity processing without obvious effects on speech perception? In this review, I attempt to clarify the role of the right hemisphere in speech perception through a careful consideration of its role in processing vocal identity. I review evidence showing that right posterior superior temporal, right anterior superior temporal, and right inferior / middle frontal regions all play distinct roles in vocal identity processing. In considering the implications of these findings for neurobiological accounts of speech perception, I argue that the recruitment of right posterior superior temporal cortex during speech perception may specifically reflect the process of conditioning phonetic identity on talker information. I suggest that the relative lack of involvement of other right hemisphere regions in speech perception may be because speech perception does not necessarily place a high burden on talker processing systems, and I argue that the extant literature hints at potential subclinical impairments in the speech perception abilities of individuals with right hemisphere damage.
The Sleeping Subject: On the Use and Abuse of Imagination in Hobbes’s Leviathan
Authors: Schwartz Avshalom M.
Published: November 2020

This paper offers a novel interpretation of the political implications of Hobbes’s theory of imagination and his solution to the threat posed by the imagination to political stability. While recent work has correctly identified the problem the imagination poses for Hobbes, it has underestimated the severity of the problem and, accordingly, has underestimated the length to which the Hobbesian sovereign will have to go in order to solve it. By reconstructing Hobbes’s account of sleep and the operation of the imagination during sleep, this paper argues that the Hobbesian sovereign who seeks to solve the problem of the imagination must maintain his subjects in a ‘state of sleep,’ by preventing any kind of new inputs from disturbing their imagination. This solution suggests that the citizens of the Leviathan state are not sleeping sovereigns, but rather sleeping subjects.
Hobbes’s Strategy of Convergence
Authors: McQueen Alison
Published: November 2020

In his political works, Thomas Hobbes proliferates arguments and overdetermines his conclusions. This article hypothesizes that at least some of this overdetermination was intentional. It was part of a “convergent strategy” meant to appeal to a broad, diverse, and unknown audience. The article draws on Leviathan to offer evidence for this hypothesis.
A Taste of Georgia. Far Right Populism with a Unique Georgian Flavour
Authors: Cole Michael
Published: November 2020

Georgia has proved no exception to recent political trends, which have seen the increased prominence and influence of far right populist parties and movements purporting to represent ‘the people’ in an antagonistic struggle against the ‘elites’ or ‘enemies’. However, while considerable academic attention has been devoted to cases in Central and Western Europe (CWE), studies of Georgian far right populism are less common. This paper examines the political styles of two Georgian far right actors, the Alliance of Patriots of Georgia (APG) and Georgian March (GM). I argue that the populist discursive frames both employ demonstrate enough commonalities with their CWE counterparts to consider them members of the far right populist ‘family’. However, the prevalence of populist politics, highly influential role of ‘traditional values’ promoted by the Georgian Orthodox Church (GOC), and Russian influence, are three important factors which produce a uniquely Georgian ‘flavour’ to far right populist movements in Georgia.
Using the Past in Populist Communicational Strategies
Authors: Chiruta Ionut Valentin
Published: November 2020

This article investigates how political strategies interrelate populist rhetoric with memory issues. By looking at the case of the Social Democratic Party (PSD) from Romania, between 2017–2019, this article reveals how the slide to populism, generated by cyclical confrontations with the rule of law institutions, steered the psd to adopt conspirational beliefs and appeal to traumatic memories to frame the judiciary as the new Securitate. Through the use of discourse analysis and virtual ethnography, this article analyses party resolutions and political rallies. This article explains how the populist rhetoric created a new hegemonic narrative of the judiciary, by intersecting its values and symbolism with the memory of the former Securitate from the Communist period.
The Gas Content Characteristics of Nanopores Developed in a Normal Pressure Shale Gas Reservoir in Southeast Chongqing, Sichuan Basin, China
Authors: Chen Fangwen , Zheng Qiang , Zhao Hongqin , Ding Xue , Ju Yiwen , Lu Shuangfang
Published: November 2020

To evaluate the gas content characteristics of nanopores developed in a normal pressure shale gas reservoir, the Py1 well in southeast Chongqing was selected as a case study. A series of experiments was performed to analyze the total organic carbon content, porosity and gas content
using core material samples of the Longmaxi Shale from the Py1 well. The results show that the adsorbed gas and free gas content in the nanopores developed in the Py1 well in the normal pressure shale gas reservoir range from 0.46–2.24 m3/t and 0.27–0.83 m3/t,
with average values of 1.38 m3/t and 0.50 m3/t, respectively. The adsorbed gas is dominant in the shale gas reservoir, accounting for 53.05–88.23% of the total gas with an average value of 71.43%. The Gas Research Institute (GRI) porosity and adsorbed gas content
increase with increasing total organic carbon content. The adsorbed gas and free gas contents both increase with increasing porosity value, and the rate of increase in the adsorbed gas content with porosity is larger than that of free gas. Compared with the other five shale reservoirs in America,
the Lower Silurian Longmaxi Shale in the Py1 well developed nanopores but without overpressure, which is not favorable for shale gas enrichment.
Characteristics and Controlling Factors of Nanopores of the Niutitang Formation Shale from Jiumen Outcrop, Guizhou Province
Authors: Guo Sen , Zhu Yan-Ming , Liu Yu , Tang Xin
Published: November 2020

This paper studies the characteristics and controlling factors of nanopores in organic-rich shale in the Niutitang Formation. Six samples were collected from the bottom of the formation at the Jiumen Outcrop, Guizhou Province. Experiments were conducted to investigate the pore structures
of these high-maturity shale samples. The TOC contents vary between 4.81–17.51% with an average of 10.18%. The XRD data show that these samples are dominated by quartz (44%–71%), with a significant amount of clay minerals, such as illite, with a content of 8%–27.5%. Based
on the low-pressure liquid N2 sorption measurements, the pore structures can be divided into two groups. Group A including samples of N-2, N-3 and N-4, mainly develop slit-shaped pores, mesopores and macropores. Group B shown from samples N-1, N-5 and N-6, are mainly composed of
narrow slitlike pores, which may provide more space for shale gas than slit-shaped pores. The mesopores, macropores, porosity and specific surface areas of group B are more developed than those of group A. With the comparison of pore structures in shales with various organic matter and mineral
contents, the dissolution of quartz and feldspar can be the important factor controlling pore development. The evolution of diagenesis is closely related to pore evolution. This diagenesis has various types and complex effects on the pores, mainly including compaction, dissolution and cementation.
Applicability Analysis of Determination Models for Nanopores in Coal Using Low-Pressure CO2 and N2 Adsorption Methods
Authors: Li Yunbo , Song Dangyu , Li Guofu , Ji Xiaofeng , Tang Junting , Lan Fengjuan , Fan Shunli
Published: November 2020

The development characteristics of nanopores (with pore sizes <200 nm) in coal are a key factor affecting the accumulation and migration of coalbed methane (CBM). Thus, an appropriate determination method and calculation model are essential for accurate nanopore representation. Based
on the experiments of low-pressure CO2 adsorption (LP-CO2GA) at 273 K and low-pressure N2 adsorption (LP-N2GA) at 77 K on four coals with different ranks, the abilities of different models (e.g., Langmuir, Dubinin-Radushkevich (D-R), Dubinin-Astakhov
(D-A), Brunauer-Emmett-Teller (BET) and nonlocal density functional theory (NLDFT)) to accurately predict the pore parameters were analyzed. The results showed that (1) for LP-N2GA, the Langmuir model is only suitable for gas adsorptions at low relative pressure conditions (P/P0
< 0.01), and its error value increased with the relative adsorption pressure. The fitting results of the D-R model showed good agreement with the D-A model under low relative pressure of LP-CO2GA (P/P0 < 0.01), and the D-A model had more accurate fitting
results. The BET model is more accurate than the other models (φ = −1.2733%) only in the interval of LP-N2GA with 0.05 < P/P0 < 0.35. The data also showed that the NLDFT model can maintain a higher fitting accuracy for LPCO2/N2GA
processes at relative adsorption pressures from 0.001–0.9996. (2) Using LP-CO2GA with the Langmuir, D-R, D-A, and NLDFT models, the micropore specific surface area (SSA; 66.9570–248.6736 m2/g) and pore volume (0.0201– 0.0997 cm3/g) were obtained,
while the values of meso-/macropore SSA (0.0007–2.3398 m2/g) and pore volume (0.0036–0.04 cm3/g) were calculated by LP-N2GA with the BET and NLDFT models. The results showed that the fitting accuracy in descending order was the D-R, D-A, Langmuir
and NLDFT models. (3) In combination with the applicable model range, LP-CO2GA with the NLDFT model was recommended for micropore analysis of the coal pore sizes from 0.36–1.1 nm, while LP-N2GA combined with the NLDFT model was recommended for nanopore analysis
of pore sizes from 1.1–200 nm. (4) The characteristics of pore development in the Beiloutian coal were analyzed using LP-CO2/N2GA combined with the NLDFT model. It was found that a pore volume and SSA less than 1.0 nm accounted for 88.82% of the total pore volume
and 98.05% of the total SSA, indicating that micropores in coal are the main space for CBM storage and are key physical factors for the occurrence and migration of coalbed methane. The conclusions of this article will provide a basis for the accurate calculation of nanopores in coal.
Molecular Dynamics Simulations of Oil-Water Wetting Models of Organic Matter and Minerals in Shale at the Nanometer Scale
Authors: Dong Zhentao , Xue Haitao , Li Bohong , Tian Shansi , Lu Shuangfang , Lu Shudong
Published: November 2020

Wettability is an important physical property of shale. This parameter is related to the shale material composition and the fluid properties in the shale pores and plays an important role in the exploration and development of shale oil. Wettability is affected by the scale and roughness. The contact angle at the nanoscale on a smooth surface can better reflect the wettability of shale than the contact angle at higher scales. Molecular dynamics simulations can be used to measure the contact angle on a smooth surface at the nanoscale. This paper focuses on the effects of organic matter and minerals in shale and different components of shale oil on shale wettability. Wetting models of “organic matter-oil component-water,” “quartz-oil component-water” and “kaolinite-oil component-water” at the nanoscale were constructed. Molecular dynamics simulation was used to study the morphological changes of different oil components and water on different surfaces. Studies have shown that organic matter is strongly oleophilic and hydrophobic. Polar components in shale oil can make organic matter slightly hydrophilic. It was recognized by quartz wettability experiments and simulation methods at the nanoscale that the cohesive energy of a liquid has a significant influence on the degree of spreading of the liquid on the surface. The “liquid–liquid–solid” wettability experiment is an effective method for determining mineral oleophilic or hydrophilic properties. The nanoquartz in the shale is strongly hydrophilic. The water wetting angle is related to the crude oil component. Nanokaolinite can have a tetrahedral or an octahedral surface; the tetrahedral surface is oleophilic and hydrophobic, and the octahedral surface exhibits strong hydrophilicity. The wettabilities of both surfaces are related to the crude oil component.
Characteristics and Implications of Nanocoatings on Gouges in a Seismically Active Fault Zone
Authors: Wang Lei , Wang Zhicai , Chao Hongtai , Yang Chuancheng
Published: November 2020

Using a ZEISS Axio Scope A1 ordinary polarizing microscope, a ZEISS Sigma 300 scanning electron microscope and a HITACHI S4800 scanning electron microscope, we observe micro/nanocharacteristics of slip planes in gouges sampled from the Tanlu fault zone, the Haiyuan fault zone and several
other Late Pleistocene active faults, such as the Haiyang fault, the Shuangshan-Lijiazhuang fault and the Xintai-Mengyin fault, in Shandong Province. Based on microscopic observation of gouges, a straight slip zone is a sign of seismic stick slipping. According to scanning electron microscopy
results, the surface of gouges is commonly covered by nanocoatings. Such coatings feature nanoparticles, aggregations, scratches, grooves, cracks and “silver lines.” According to the characteristics of nanomaterials, we believe that nanocoatings on gouges could help rapidly unload
tectonic stress in the process of energy accumulation and weaken the strength of the active fault, which is beneficial to creep slipping and has a weakening effect on seismogenesis.
Study of Modified Dry Desulfurization Ash in a Power Plant for Sequestering CO2from a Micron-Nanoscale Perspective
Authors: Cai Jieying , Li Xiangdong , Chen Di , Feng Qiyan
Published: November 2020

To improve the CO2fixation ability of dry desulfurization ash (DDA), a DDA must be modified by chemical methods. At the micron level, the changes in microstructure and chemical composition before and after DDA modification were analysed by Scanning Electron Microscope (SEM) and Energy Dispersive Spectroscopy (EDS), and the reaction mechanism of the modification process was inferred. On the other hand, the chemical and mineral phase compositions of the modified DDA and its solid products were analysed by X ray Fluorescence (XRF) and X-ray diffraction (XRD). In addition, the microstructure of the modified DDA before and after sequestration at nanometre resolution was studied by SEM-EDS so that the curing mechanism of the modified DDA was clearly defined. Then, the effects of the solid–liquid ratio, temperature, pressure and reaction time on the sequestration of CO2in the modified DDA were studied with aqueous carbonation. The results showed that the higher the temperature is, the higher the solid–liquid ratio, and the lower initial pressure is, the less the CO2sequestered in the modified DDA and the less the carbon sequestration capacity of the modified DDA. Under the experimental conditions, the carbonation efficiency of the modified DDA could reach 94.42%, and 1 ton of modified DDA could sequester up to 50.61 kg CO2. Compared with conventional DDA, the carbon sequestration capacity is effectively improved. The kinetic data confirmed that the fitting correlation of the quasi-first-order kinetics equation is more significant. The smaller the solid–liquid ratio is, the lower the temperature, the higher the initial pressure, and the higher the rate constant of the quasi-first-order kinetics equation.
Small Angle X-ray Scattering Test of Hami Coal Sample Nanostructure Parameters with Gas Adsorbed Under Different Pressures
Authors: Nie Baisheng , Wang Kedi , Fan Yu , Zhao Junsheng , Zhang Letong , Ju Yiwen , Ge Ze
Published: November 2020

The complexity and multiscale structure of coal pores significantly influence the gas diffusion and seepage characteristics of coal. To apply small angle X-ray scattering (SAXS) to study the coal pore structure parameters within the scale of 1–100 nm in the methane adsorption
process, the X-ray window was optimized and a gas adsorption chamber was designed to interface with the small angle X-ray scattering platform. The fractal dimension and porosity of Hami coal samples under different methane pressures were studied using the small angle X-ray scattering platform
and adsorption chamber. The surface and nanopore fractal information of the nanopores in coal were distinguished. The variation trends of the pores and surface fractal dimension with time under the same methane pressure were compared. The results indicate that the surface dimension changes
from 2.56 to 2.75, and the extremum point may indicate that the primary nanopore structure is crushed by the adsorbed gas after approximately 15 minutes. This work clarifies that the fractal dimension can characterize the changes in nanopores in the process of gas adsorption by using SAXS.
According to the fractal characteristics, the adsorption of gas in coal nanopores is summarized as four steps: expansion from adsorbance, deformation, crushing and recombination. The minimum porosity is 0.95% and the extreme value point is 1.47%. This work also shows that decrease in surface
energy affect the porosity changes in nano-size pores. This work is of some significance to coalbed methane permeability improvement and gas extraction.
Characterization of the Heterogeneous Evolution of the Nanostructure of Coal-Based Graphite
Authors: Cao Daiyong , Wang Lu , Ding Zhengyun , Peng Yangwen , Li Yang
Published: November 2020

The graphitization of coal is complicated due to multiple factors, such as magmatic intrusions, tectonic stresses and the catalysis of minerals. Heterogeneous graphitization was found based on the nanostructural characterization of anthracite and coal-based graphite. It was determined
that the graphitization of coal is not only the rearrangement of carbon layers but also the extinction of structural defects, as revealed by the evolution of XRD and Raman spectra and structural parameters (i.e., the interlayer spacing d002 and R2). Based on a comprehensive analysis of the
nonstructural evolution of coal, the graphitization of coal could be divided into four stages at the nanoscale. The first stage (d002 > 0.344 nm and R2 < 0.7) is the transition process from coalification to graphitization, the second (0.337 nm < d002 ≤ 0.344 nm and R2 > 0.65)
is the crystallization of carbon layers, the third stage (0.337 nm < d002 ≤ 0.344 nm and R2 ≤ 0.65) is characterized by the elimination of structural defects and straightness of carbon layers, and the fourth stage (d002 ≤ 0.337 nm and R2 ≤ 0.6) shows that the locally ordered
graphite structure expanded to the whole sample.
Evaluation of the Geochemical Characteristics and Exploitation Potential of Produced Water from Coalbed Methane Wells in Eastern Yunnan, China
Authors: Du Mingyang , Wu Caifang , Zhang Shasha , Liu Xiaolei
Published: November 2020

Based on the analysis of the geochemical characteristics of the produced water from coalbed methane wells in eastern Yunnan, the effects of the water-rock interactions on the produced water were discussed, and the mining potential of each of the four wells was evaluated. The results
show that with the increase in drainage time, the Na+ and Cl− concentrations decrease while the HCO−3 concentration increases. The produced water from the two wells in the Enhong Block shows D drift characteristics, while that of the
two wells in the Laochang Block shows O drift characteristics. The order of the produced water affected by the surrounding rock is D-1 well > M-1 well > D-2 well > M-2 well, and the order of the produced water influenced by the coal seam is D-1 well > D-2 well > M-1 well >
M-2 well. According to the variation in the As trace element concentration, it is inferred that in the four coalbed methane wells, the D-1 and D-2 wells have a greater exploitation potential than that of the M-1 and M-2 wells. On this basis, the influencing characterization parameters of the
water-rock interactions on the produced water are established.
Effects of Water Immersion and Acidification on Nano-Pores in Tight Sandstones—A Case Study of the Gaotaizi Reservoir, Songliao Basin
Authors: Wang Min , Jiao Chenxue , Zhou Nengwu , Li Chuanming , Tang Mingming , Wang Hailong , Lu Shuangfang
Published: November 2020

Hydraulic fracturing and acidification are among the most commonly used methods for stimulating the tight oil reservoirs and improving oil recovery. Therefore, examining the effects of water immersion and acidification on tight oil reservoirs is important for oilfield development plans.
Core flooding testing, which analyzes the influence of core permeability variations before and after acid injection on the reservoir quality, is the conventional research method; however, it is difficult to observe the changes in minerals and pores caused by acidulation and water immersion
in situ. In this study, we conduct field-emission scanning electron microscopy (FE-SEM), MAPS, the quantitative evaluation of minerals through scanning electronic microscopy (QEM-SCAN), and describe the types of pores in tight sandstone. Further, the effects of water immersion and acidification
on pores in tight sandstone were studied. The results indicate that: (1) intergranular pores, intragranular dissolution pores, clay mineral intercrystalline pores, and micro-cracks were developed in the Gaotaizi tight sandstone in Songliao Basin, with the intergranular pores observed to be
dominant; (2) the hydration of clay minerals induced by water injection caused plugging of pores at the nanometer– micrometer scale, and plane porosity is slightly reduced (˜0.86%); (3) acidification resulted in the dissolution of carbonate minerals, increasing the porosity of
the reservoir, therefore, the increase in porosity is influenced by the carbonate mineral content. We recommend that future studies should investigate the content, type, and distribution of carbonate minerals in the operation area. During the process of reservoir stimulation, such as acidification
and CO2 injection- and-production, the influence of carbonate minerals dissolution on oil production should be considered.
Micro-Nanoscale Characteristics of Pyrite and Its Implications for Gold Mineralization: Two Cases of Gold Deposits in the Youjiang Basin and Southwestern Tianshan Mountains
Authors: Feng Hongye , Ju Yiwen , Chen Bo , Fang Weixuan , Zhu Hongjian , Li Wuyang , Ju Liting , Qiao Peng
Published: November 2020

The mineralogical and compositional characteristics of gold-bearing minerals and the occurrence of gold are not only of great significance to exploring the sources of ore-forming materials and their formation mechanisms but also helpful for designing reasonable beneficiations and smelting schemes and achieving remarkable economic benefits. This paper presents an integrated study on the crystal characteristics, elemental composition and distribution of pyrite (the main gold-bearing minerals), on the basis of electron probe microanalysis (EPMA), scanning electron microscopy (SEM), laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) and nano-secondary ion mass spectrometry (NanoSIMS). The occurrence of gold in the Shuiyindong gold deposit and Ashawayi gold deposit has been studied by means of microscopy, SEM, and EPMA images, elemental correlations, S–Fe–As ternary diagrams, logAs–logAu diagrams and Au/As ratios. The gold in pyrite of the Shuiyindong deposit is in the form of nano gold inclusions and lattice gold. The gold in pyrite of the Ashawayi deposit dominantly exists in the form of nano gold inclusions or is present as micro-nano gold particles in the cracks or edges of pyrite, some of which can exist as lattice gold. The ore-forming hydrothermal solution of the Shuiyindong gold deposit is mainly underground hot brine, but it may be reformed by a deep magmatic hydrothermal solution or volcanic-subvolcanic hydrothermal solution. The ore-forming hydrothermal solution of the Ashawayi gold deposit is mainly derived from the metamorphic hydrothermal solution formed during the orogenic process, and the ore-forming process or post-mineralization process may be reformed by the leaching of underground hot brine. Finally, the characteristics of ore-forming fluids and evolution of the two types of deposits are determined via pyrite element surface scanning. This paper shows that micro-nanoscale study of gold-bearing pyrite is of great significance to understanding the gold mineralization process and is worth further study.
Mineral Composition and Its Control on Nanopores of Marine-Continental Transitional Shale from the Ningwu Basin, North China
Authors: Zhang Bao-Xin , Fu Xue-Hai , Shen Yu-Lin , Zhang Qing-Hui , Deng Ze
Published: November 2020

There is a large difference between the sedimentary environment and maturity of organic matter between marine shale and marine-continental transitional shale. It is of great significance to discuss the effect of inorganicminerals on the pores for marine-continental transitional shale
gas exploration. In this study, scanning electron microscopy (SEM), low temperature liquid nitrogen adsorption and Xray diffraction (XRD) were conducted on eight marine-continental transitional shale samples from the Ningwu Basin, Shanxi Province, China. The pore structure differences in the
different minerals were discussed, and the relationship between the mineral content and pore parameters was analysed. The results show that the mineral composition of shale is dominated by clay minerals, quartz, carbonate minerals and a small amount of pyrite. The clay minerals content is
between 39.5% and 77.0%, with an average of 59.9%. The quartz content ranges from 21.8% to 47.8%, with an average of 31.9%. The carbonate minerals content in shale is between 0.6% and 23.9%, and the average is 6.3%. The clay minerals are composed of mixed illite-montmorillonite layer, kaolinite
and chlorite. The content of mixed illite-montmorillonite layer is between 13.8% and 27.4%, with an average of 20.4%. The kaolinite content ranges from 57.0% to 86.2%, with an average of 76.0%. The content of chlorite is between 0 and 15.6%, with an average of 5.7%. The types of pores are
mainly intergranular pores and interlaminar pores, which are mostly presented as slit and parallel plates. The mixed illite-montmorillonite layer contributes more to the specific surface area, which is favourable for shale gas adsorption. The pores in kaolinite are more developed than those
of the mixed illite-montmorillonite layer, but the pore diameter is relatively large. The quartz granule has a complete crystal type, and intergranular pores with a large pore size are often developed at the mineral contacts. Compared with clay minerals and quartz, the pore development in
the carbonate minerals is relatively poor and develops more micro-fractures. The pyrite contributes a certain number of intergranular pores and mold pores.
On the Origin of White Hollywood: The Racialized Space of the U.S. Film Industry
Authors: Thakore Bhoomi K.
Published: November 2020

The scholarship on White spaces has highlighted the ways in which institutions have devoted themselves to reproducing Whiteness through intentional ideological work, and how the prevalence of such ideologies impact the individuals within these spaces. It is well recognized that experiences are racialized within U.S. social institution, but there needs to be more work on highlighting the origins of such ideologies within each context. In this article, I focus on the Hollywood film industry to emphasize how its history and contemporary practices do just that. Furthermore, the effects of such practices on the content created by Hollywood reinforce mediated representations that not only reproduce stereotypes at the interactional level but also reinforce the ideological status quo of White Hollywood. I conclude with a reflection on how any changes to the structure must be strategic, lest we repeat the same mistakes of other so-called “integrated” institutions.
All the World Is a Nail: Why Are Surgeons Resistant to Learn How to Place Cholecystostomy Drains in Seriously Ill Patients With Acute Acalculous Cholecystitis?
Authors: Requarth Jay
Published: November 2020

Surgeons routinely provide palliative care, but often the technical procedure needed for the palliative intervention is beyond our training and comfort zone. This case is an example of surgical palliative care that utilizes image-guided techniques to provide optimal care. A frail elderly patient with multiple comorbidities who had been hospitalized for other diseases was diagnosed with acute acalculous cholecystitis. General surgery and gastroenterology were initially consulted, and the patient was referred to interventional radiology for a percutaneous cholecystostomy. The procedure was technically successful, and the patient’s clinical status improved. A few days later, a follow-up cholecystogram showed a decompressed gallbladder, patent cystic duct, a common bile duct free of stones, and dilute contrast in the duodenum. After 2 weeks, the fistula tract was interrogated and found to be intact. The cholecystostomy tube was removed without incident. This case is presented as a call to action for surgeons to learn the skills required to place percutaneous cholecystostomies themselves and to add it to their surgical armamentarium.
Chronic and Sudden Serious Illness, COVID-19, and Decision-Making Capacity: Integrating Advance Care Planning Into the Preoperative Checklist for Elective Surgery
Authors: Rivet Emily B. , Blades Candace E. , Hutson Mary , Noreika Danielle
Published: November 2020

Advance Care Planning (ACP) includes anticipating future medical decisions and designating a medical decision maker in the event of losing the capacity to make one’s own medical decisions. Many advantages can be seen to doing ACP before a crisis as well as revisiting these discussions over time as circumstances change. This case presentation is of a 74-year-old woman with multiple medical problems who had ACP discussions in the context of proposed surgery for colon cancer. These conversations highlight the elements of high-quality ACP and the importance of learning what patients mean when they employ phrases commonly referenced in these conversations. The planned surgery was delayed by the COVID-19 pandemic but the discussions helped to guide decision-making when the patient became critically ill with COVID-19.
The Future of Labor Localism in an Age of Preemption
Authors: Johnson Olatunde C. A.
Published: November 2020

In recent years, labor and civil rights groups have successfully pushed for local regulation raising the minimum wage, creating new parenting and sick leave policies, and broadening anti-discrimination protections to address sexual orientation and gender identity discrimination. This article examines the viability of this worker-protective regulation at the local level in the face of current legal and political challenges. In particular, it considers the rise of state preemption laws that overturn local ordinances, which is the product of anti-regulatory mobilization at the state legislative level. The article provides case studies of state preemption and offers potential legal arguments for challenging preemption and safeguarding labor and civil rights localism. The author concludes, however, that given the uncertainty of whether these legal arguments will prevail in court, civil rights and labor advocates will need to engage politics at the state level to preserve and expand local innovations.
Organizational Dehumanization and Emotional Labor: A Cross-Cultural Comparison Between Vietnam and the United Kingdom
Authors: Nguyen Nathan , Dao Quoc Anh , Nhan Thi Lac An , Stinglhamber Florence
Published: November 2020

This study examined cross-cultural differences in the relationships between organizational dehumanization and both job satisfaction and turnover intentions through emotional labor (i.e., surface acting). In particular, we expected that power distance, that is, a critical value usually discussed as part of the national culture, would mitigate the deleterious effects of both organizational dehumanization and surface acting on job satisfaction and turnover intentions. Data were collected from employees in two countries that differ in power distance, namely Vietnam ( N = 235) and the United Kingdom ( N = 334). First, we found that perceptions to be dehumanized by one’s organization were indirectly related to poor job satisfaction and more turnover intentions through surface acting, regardless of the country. Second, our results showed that the deleterious effects of both organizational dehumanization and surface acting on work-related outcomes were weaker in Vietnam (a high power distance country) than in the United Kingdom (a low power distance country). Theoretical and practical implications are discussed from the perspective of organizational dehumanization and emotional labor literature.
Organizational Herding in Advertising Spending Disclosures: Evidence and Mechanisms
Authors: Shi Huanhuan , Grewal Rajdeep , Sridhar Hari
Published: November 2020

As firms use advertising to gain product market advantages and increase their valuation in financial markets, disclosing their advertising spending is influential—whether it erodes organizational competitive advantages in product markets or signals quality in financial markets. The authors argue that firms learn from peers’ decisions to reduce the uncertainty in their own advertising disclosure, and they empirically investigate information-based organizational herding in the context of advertising spending disclosure, where a 1994 reporting rule made advertising spending disclosures voluntary in the United States. The authors examine whether a firm relies on information from benchmark leaders or similar peers to resolve disclosure uncertainty. A novel identification strategy, which uses partially overlapping strategic groups to mitigate simultaneity and correlated unobservables, shows robust evidence for herding effects among peer firms in the same strategic group. Moreover, firms are more likely to resolve disclosure uncertainty from similar peers rather than from benchmark leaders. The authors discuss how firms can use knowledge of competitors’ predicted advertising disclosure decisions conditional on their disclosure to their strategic advantage in product and financial markets.
How often is autopsy contributory in cases of sepsis?
Authors: Bosco Emily , Langlois Neil
Published: November 2020

This study sought to determine how often a medico-legal (coronial) autopsy contributes by identifying the source of infection when there has been a clinical diagnosis of sepsis prior to death. Autopsy reports were retrieved in which it was documented there had been a clinical diagnosis of sepsis preceding death. The autopsy report was reviewed to determine if a source for sepsis had been identified. It was found the autopsy was contributory in this respect in less than one fifth of all cases (35 of 198, 18%). It was also determined if there was a post-autopsy diagnosis of sepsis or if sepsis was excluded by a definite alternative diagnosis. During the study, of the 198 cases, sepsis was excluded by an alternative diagnosis in 78 (39%). Thus, the autopsy may be of more application to confirming or excluding a diagnosis of sepsis than identifying a source for sepsis.
Potential significance of swastika tattoos in a medico-legal setting
Authors: Byard Roger W
Published: November 2020

Although the increasing popularity of tattoos has challenged the previous associations with criminality and psychiatric illness, particular subsets of tattooed individuals may still have an association with unnatural deaths in a forensic context. A retrospective review of the autopsy database at Forensic Science South Australia was undertaken over a 23-year period from 1997 to 2019 for cases with swastika tattoos. Twenty-six cases (23 males and 3 females) were identified, ranging in age from 19 to 67 years ( Mage = 36 years). The cases comprised seven (27%) suicides, seven (27%) accidents (including five vehicle crashes), five (19%) drug-related deaths (toxicity/overdose), four (15.4%) natural deaths and three (11.5%) homicides. There were significantly more unnatural deaths in the group with swastika tattoos compared to tattooed controls ( p < 0.01). Multiple swastikas, expletives and white supremacist sentiments were also present in a number of cases. However, in one Asian male, the presence of a sacred Buddhist tattoo suggested that the swastika tattoo instead had religious rather than antisocial/racist significance. This study shows that in the population of individuals undergoing forensic autopsies, subgroups may be identified by their tattoos who have a predisposition to violent and unnatural death. Evaluation of this risk has to be tempered by considering the cultural/religious background of a decedent, as the symbol may have completely different connotations for certain religious groups such as Jains, Hindus and Buddhists.
PID-5 Trait Indicators of Emotional Instability and Childhood Adversity Antecedents
Authors: King Alan R.
Published: November 2020

Personality traits provide natural mechanisms through which childhood maltreatment may translate into psychiatric symptomatology. The PID-5 has provided a DSM-supported exemplar for canvassing traits that may contribute to the developmental trajectories of many personality and mood disorders. This general population survey ( N = 2,430) examined associations between adverse childhood experiences (ACE questionnaire) and selected PID-5 trait indicators of emotional well-being (Depressivity, Anxiousness, and Emotional Lability). These associations were contrasted with others derived from traditional dimensional measures of childhood maltreatment. ACE counts and all six of the dimensional maltreatment indicators were linked to the three trait scores. Family emotional abuse and ACE counts provided equally strong correlates of Depressivity and Anxiousness. ACE counts and childhood sexual abuse were especially strong in their associations with all three traits. Graded relationships were found in these trait-adversity relationships with polyvictimized respondents generating the highest personality maladjustment. The odds of a trait score elevation (>1 SD) were raised substantially (two to five fold) by singular adversity exposures, and the co-occurrence of only two different forms of adversity maximized odds of extreme trait expression. These results contribute to an evidentiary base suggesting steeper developmental trajectories for personality maladjustment among maltreated youth.
Branched internal mammary conduit permits non-sequenced total arterial revascularization
Authors: Baldwin Andrew CW , Tolis George
Published: November 2020

Recent trends in cardiac surgery have encouraged total arterial coronary revascularization, citing advantages in long-term patency and overall mortality. Often relying on sequenced, composite, and free-graft strategies, total arterial coronary revascularization is limited by conduit availability and surgical complexity. We present the use of bilateral internal mammary artery grafts to achieve nonsequential 3-vessel total arterial coronary revascularization using the preserved distal bifurcation of the right internal mammary artery. Utilization of distal internal mammary artery branches should be considered a viable strategy in select patients and can broaden the opportunities for total arterial coronary revascularization in patients with multivessel coronary disease.
Visual function and visual ability in adolescents with oculocutaneous albinism
Authors: Naipal Shivani , Rampersad Nishanee
Published: November 2020

Individuals with ocular and oculocutaneous albinism (OCA) have significantly reduced visual acuity (VA) resulting in visual impairment (VI). The aim is to report on the visual function of adolescents with OCA and their quality of life (QoL) in terms of their visual ability. A total of 28 adolescents with OCA participated in this study. Tests of visual function included distance VA, refractive error, contrast sensitivity (CS), and colour vision. The Cardiff Visual Ability Questionnaire for Children (CVAQC) was used to assess visual ability. All participants presented with cutaneous hypopigmentation and nystagmus, while only two had strabismus. A mean myopic refractive error was found, and with-the-rule (WTR) astigmatism was most common. The mean best-corrected VA was 0.81 ± 0.17 logMAR and 0.81 ± 0.18 logMAR in the right and left eyes, respectively. The mean CS with the best refractive correction was 1.23 ± 0.33 log CS in the right eye and 1.29 ± 0.33 log CS in the left eye. The mean Cardiff visual ability score was −0.37 ± 0.79 log units. The variation of refractive errors and the magnitude thereof underscores the need for regular eye examinations in individuals with OCA. The majority of participants had moderate VI, and these participants had a better mean Cardiff visual ability score than those with severe VI. Similarly, participants with normal binocular CS had a better Cardiff visual ability score than those with a loss of CS.