bluuebunny/crossref_metadata_2025 huggingface dataset:
Laparoscopic and Open Distal Pancreatectomy—An Initial Single-Institution Experience with a Propensity Score Matching Analysis
Authors: Plahuta Irena , Šarenac Žan , Golob Medeja , Turk Špela , Ilijevec Bojan , Magdalenić Tomislav , Potrč Stojan , Ivanecz Arpad
Published: January 2025

Laparoscopic distal pancreatectomy is a minimally invasive approach for the surgical treatment of neoplasms in the distal pancreas. This study aimed to compare this approach to the open procedure. A retrospective analysis of a prospectively maintained database of 400 pancreatectomies was performed. The laparoscopic distal pancreatectomy group (LDP) was compared to the open distal pancreatectomy group (ODP). A propensity score matching analysis (PSM) was performed. From 2016 to 2023, 108 distal pancreatectomies were carried out, 19 (17.6%) laparoscopically and 89 (82.4%) openly. The conversion rate was 13.6%. The severe morbidity rates were 28.1% in the ODP group, 47.4% in the LDP group, and 15.8% in the ODP-PSM group. The difference between the latter two was statistically significant (p = 0.034) due to the high rate of Clavien–Dindo grade 3a complications (42.1% versus 10.5%, p = 0.042) in the LDP group. The 90-day mortality rates were 3.3% in the ODP group and 5.3% in the other two groups. The LDP group had a shorter duration of intravenous narcotic analgesia (5 versus 7 days, p = 0.041). There was no difference in the R0 resection or postoperative pancreatic fistula rates. Our attention should be drawn to preventing postoperative complications because the oncological outcomes are already comparable with those of the open procedure, and postoperative pain management is promising.
Emotion Recognition from EEG Signals Using Advanced Transformations and Deep Learning
Authors: Cruz-Vazquez Jonathan Axel , Montiel-Pérez Jesús Yaljá , Romero-Herrera Rodolfo , Rubio-Espino Elsa
Published: January 2025

Affective computing aims to develop systems capable of effectively interacting with people through emotion recognition. Neuroscience and psychology have established models that classify universal human emotions, providing a foundational framework for developing emotion recognition systems. Brain activity related to emotional states can be captured through electroencephalography (EEG), enabling the creation of models that classify emotions even in uncontrolled environments. In this study, we propose an emotion recognition model based on EEG signals using deep learning techniques on a proprietary database. To improve the separability of emotions, we explored various data transformation techniques, including Fourier Neural Networks and quantum rotations. The convolutional neural network model, combined with quantum rotations, achieved a 95% accuracy in emotion classification, particularly in distinguishing sad emotions. The integration of these transformations can further enhance overall emotion recognition performance.
A Novel Methodology for Performance Evaluation in Advanced Quality Control
Authors: García Ethel , Peñabaena-Niebles Rita , Percybrooks Winston S. , Palomino Kevin
Published: January 2025

Current global conditions and challenges in industrial manufacturing, marked by dynamism, competition, and the need for responsible resource management, have increased the demand for sustainable manufacturing practices. The integration of Industry 4.0 and the recent development of Industry 5.0 have added dynamism, which has generated profound implications for quality control and process monitoring, focusing mainly on recognising control patterns within the manufacturing environment. This study introduces a novel methodology for evaluating the performance of pattern classification models used in advanced quality control. Our approach incorporates robust performance metrics, early detection, window size, network hyperparameters, and concurrent patterns within a simulated monitoring environment. Unlike previous research, our evaluation methodology addresses the sensitivity of classification models to various factors, emphasising the critical balance between early detection and minimising false alarms. The findings reveal that window size significantly impacts the model’s sensitivity to pattern changes, highlighting that measuring early detection alone is impractical in real-world applications. Furthermore, optimal hyperparameter selection enhances the model’s practical applicability.
Investigation of a Biochemical Model with Recycling in Case of Negative Cooperativity
Authors: Nikolov Svetoslav G. , Vassilev Vassil M. , Nenov Momchil I.
Published: January 2025

The objective of this paper is to find new dynamic perspectives in a well-known two dimensional nonlinear system which is a modification of the phosphofructo kinase model by incorporating recycling of the product, p, into the substrate, s. Specifically, we investigate the affect of the negative cooperativity on the number of equilibria and their stability. Moreover, in the parameter space, we analyze analytically and numerically the number of periodic oscillations (solutions) and their stability using Lyapunov coefficients (in other words, quantities and focus values). Thus, we obtain that three different dynamical conditions (regimes) take place: (1) structurally unstable, (2) the existence of an unstable limit cycle with an external stable limit cycle, and (3) the existence of a stable limit cycle with an external unstable limit cycle. Moreover, for a zero rate of product synthesis (due to e.g., defective enzyme), we obtain that the modified system has a first integral.
Eu-Substituents-Induced Modifications in the Thermoelectric Properties of the Zintl Phase Ba1-xEuxZn2Sb2 System
Authors: Shim Daewon , Lee Junsu , Ahmed Aziz , Pi Ji Hee , Choi Myung-Ho , Ok Kang Min , Lee Kyu Hyoung , You Tae-Soo
Published: January 2025

Four quaternary Zintl phase thermoelectric (TE) materials belonging to the Ba1-xEuxZn2Sb2 (x = 0.02(1), 0.04(1), 0.08(1), 0.15(1)) system were successfully synthesized using the molten Pb-flux or the conventional high-temperature reaction methods. Their crystal structures were characterized by both powder and single-crystal X-ray diffraction analyses, and all four isotypic title compounds adopted the orthorhombic BaCu2S2-type (Pnma, Z = 4, Pearson code oP20) structure. The radius ratio criterion, based on the cationic and anionic elements (i.e., r+/r−), was successfully verified in the title system, as in our previous reports, where r+/r− > 1 for the BaCu2S2-type structure. A series of density functional theory calculations were performed using a hypothetical model with the idealized compositions of Ba0.75Eu0.25Zn2Sb2, and the results were compared with the ternary parental compound BaZn2Sb2 to understand the influence of Eu substituents in the Ba1-xEuxZn2Sb2 system. A similar overall shape of the density of states (DOS) curves and the near-constant DOS values at EF before and after the cationic substitution suggest only marginal changes in the carrier concentration. Therefore, carrier mobility has a dominant role in rationalizing the observed variations in the electrical transport properties of the title system. Temperature-dependent TE property measurements proved that an increase in the Seebeck coefficient S and a decrease in electrical conductivity σ were observed as the Eu substituents gradually increased in the Ba1-xEuxZn2Sb2 system, although the overall S and σ values were lower than those in the parental compound BaZn2Sb2. The thermal conductivities of these title compounds were successfully lowered by phonon scattering, but due to the overall smaller electrical transport properties, the observed maximum ZT was 0.49 at 773 K for Ba0.98(1)Eu0.02Zn2Sb2.
Computational Assessment of Biocompatibility and Toxicity of Graphene and Its Derivatives for Dental Adhesives
Authors: Saini Ravinder
Published: January 2025

Background/Objectives: Graphene and its derivatives have garnered attention for their unique properties that could enhance dental biomaterials. Understanding their interactions with biological systems is crucial for optimizing their application in dentistry. This study aimed to comprehensively evaluate the biocompatibility, molecular interactions, and toxicity profiles of graphene and its derivatives for potential dental applications using in silico approaches. Methods: The study employed molecular-docking simulations, 100 ns molecular dynamics (MD) simulations, pharmacophore modeling, and in silico toxicity assessments. Key bone-related proteins and receptors were selected to assess the potential of graphene-based materials in dental restorative and regenerative therapies. Results: Molecular-docking simulations revealed strong interactions of Graphene Quantum Dots (GQDs) and sulfur-doped graphene with critical bone-related receptors, suggesting their potential for reinforcing dentin and promoting bone regeneration. MD simulations demonstrated stable complex formations, with occasional fluctuations indicating areas for material optimization. In silico toxicity assessments indicated favorable profiles for high-purity graphene and selected doped graphenes (nitrogen-, fluorine-, and sulfur-doped), while graphene oxide (GO) exhibited concerning toxicity levels, highlighting the importance of mitigating strategies. Conclusions: Graphene and its derivatives exhibit promising biocompatibility and molecular interaction profiles relevant to dental applications. Challenges such as GO’s toxicity and occasional instability in simulations suggest the need for further research into surface modifications and material refinement. These findings pave the way for advancing graphene-based dental materials toward clinical implementation, potentially revolutionizing dental prosthetics and treatments.
Musical Expression: From Language to Music and Back
Authors: Guter Eran
Published: January 2025

The discourse concerning musical expression hinges on a fundamental analogy between music and language. While the extant literature commonly compares music to language, this essay takes the reverse direction, following Wittgenstein’s approach. The discussion contrasts the theoretical underpinnings of the “music as language” simile with those of the “language as music” simile. The emphasis on characterization, performance, mutual tuning-in relationships, the interaction between language and music, and the open-ended effort to reorient ourselves as we draw in significance challenges the “informing paradigm” that has been paramount across contemporary philosophical theories of musical expression. One of the most promising philosophical avenues that emerges as we move beyond the “informing paradigm” is recognizing the inseparable relationship between musical expression and our power to shape our own language.
Ajuga reptans L. Herb Extracts: Phytochemical Composition and Pharmacological Activity Screening
Authors: Maliuvanchuk Svitlana , Grytsyk Andriy , Popadynets Oksana , Kotyk Taras , Raal Ain , Koshovyi Oleh
Published: January 2025

The genus Ajuga (Lamiaceae family) comprises approximately 300 species, which are widely used in traditional medicine for their diaphoretic, antiseptic, hemostatic, and anti-inflammatory properties, but scarcely in official ones. Therefore, the study of Ajuga reptans holds promise for developing new medicinal products. In aqueous and aqueous-alcoholic soft extracts of the A. reptans herb, 16 amino acids, 20 phenolics, and 10 volatile substances were identified by HPLC and GC/MS. The assays of the main substances’ groups were also determined by spectrophotometry (vitamin K1, polyphenols, tannins, flavonoids, and hydroxycinnamic acids) and titrometry (ascorbic and organic acids). A. reptans herb extracts are practically non-toxic, exhibit hepatoprotective activity (dose 25 mg/kg) in experimental carbon tetrachloride-induced hepatitis, moderate anti-inflammatory activity (dose 100 mg/kg) in carrageenan-induced edema models, and possess significant local hemostatic (reducing bleeding time by 40.6%) and wound-healing properties (complete wound healing after 9 days). The aqueous-ethanolic soft A. reptans extract (extractant 50% ethanol) demonstrated the most pronounced hepatoprotective and anti-inflammatory effects. A. reptans extracts are capable of inhibiting the growth of microorganisms and showing higher activity against Gram-positive bacteria. A. reptans herb extracts are promising agents for implementation in official medicine as wound healing and hepatoprotective remedies after further preclinical and clinical studies.
Challenges in the Characterization and Purification of (Peptide)n-Calix[4]Resorcinarene Conjugates Synthesized via Thiol-Maleimide Reaction Using Liquid Chromatography
Authors: Niño-Ramírez Victor Alfonso , Maldonado Mauricio , Cuero-Amu Kelin Johana , García-Castañeda Javier Eduardo , Rivera-Monroy Zuly Jenny
Published: January 2025

The separation and purification of molecular compounds and their functionalized derivatives is a common challenge in organic synthesis. In particular, calix[4]resorcinarenes present a high potential for chemical derivatization at their upper edge by aminomethylation reactions, and these compounds and their derivatives require appropriate analytical methodologies for their analysis, separation, and purification. In this study, C-tetra(propyl)calix[4]resorcinarene was synthesized and functionalized with maleimide groups by optimized aminomethylation reactions, obtaining a mixture of mono-, di-, tri-, and tetrasubstituted compounds. Initial separation by RP-HPLC with a core-shell column showed poorly resolved peaks, indicating a loss of separation efficiency. Therefore, a monolithic C18 column was used, which significantly improved the separation, thanks to its larger pore volume and continuous structure facilitating the diffusion of these bulky molecules, notably improving efficiency. Finally, the six compounds functionalized with maleimide groups were efficiently separated and enriched by RP-SPE by analytical method transfer, and the two peptides of six and the thirteen residues derived from LfcinB (20–25): RRWQWR were synthesized by SPPS-Fmoc/tBu and purified. These were modularly linked by the Michael thiol-maleimide addition reaction obtaining six (peptide)n-resorcinarene conjugates. The analytical method by RP-HPLC with a monolithic C18 column, the separation and purification by RP-SPE were used transversally in all the steps to obtain compounds with adequate purities and quantities. Finally, the antibacterial activities of the six conjugates were evaluated against E. coli and E. faecalis strains, and it was determined that three aminomethylated compounds and one monosubstituted conjugate showed activity against E. faecalis. Our work established a new modular conjugation strategy between calix[4]resorcinarenes and peptides by thiol-maleimide click chemistry, and a methodology of separation, purification, and enrichment for these products by RP-HPLC and RP-SPE, which permitted us to obtain quantities with purities appropriate for their characterization by NMR, LC-MS and antibacterial activity assays.
Secular-Believing Diasporic Jews: The Grassroots Theology of Paul Simon and Leonard Cohen
Authors: Lahav Hagar
Published: January 2025

By analyzing the musical works of Paul Simon and Leonard Cohen, this study examines the theological expressions of secular Jews in the diaspora who retain elements of belief. Drawing on contemporary theories of lived religion and post-secular spirituality, it explores how their lyrics articulate distinctive forms of Jewish spirituality outside traditional frameworks. Through a close textual analysis of their final albums, this study reveals complex theological narratives that intertwine Protestant-oriented individual spirituality with collective Jewish religious and cultural memory. The findings indicate that Cohen and Simon demonstrate distinct approaches to divinity. Cohen adopts a more traditional theistic stance, whereas Simon develops a pantheistic theology. These narratives offer viable and meaningful models for secular-believer Jewish identity and suggest possible foundations for a contemporary secular Jewish existence in the diaspora.
Sentiment Evolution of Online Public Opinion of Emergency Situations in Railway Stations: A Case Study of Wuhan Railway Stations
Authors: Wu Yifan , Zhang Fan , Chan Albert P. C. , Li Dezhi
Published: January 2025

Preventing secondary crises resulting from emergency incidents in engineering projects is a crucial and complex task for project operation management. Public opinion and its underlying sentiment can act as reliable indicators, reflecting the progression of emergency incidents, and warrant serious consideration. With the advent of Web 2.0, the management of online public opinion (OPO) through social platforms has advanced significantly. However, previous research has overlooked the diverse categories of participants contributing to OPO evolution. This article proposes an optimised bounded confidence model (BCM) for sentiment OPO evolution under emergency situations at railway stations, incorporating multiple participant categories. A conceptual model based on eleven assumptions is developed, involving four key participants (netizens, media, opinion leaders, and government) structured into four sub-processes. To illustrate this model, the case of the Wuhan railway stations’ blockade during the COVID-19 outbreak is examined. This case study demonstrates the initial data acquisition and simulation process. The standard simulation results are recorded, followed by a multiple-sensitivity analysis to investigate the impact of various critical factor combinations on OPO evolution. Finally, policy recommendations are provided to government departments to enhance their response to emergency situations, particularly those involving railway stations, thereby ensuring public safety.
Public Perceptions of Resilient Design Characteristics in Urban Form
Authors: Yuan Shuai , Maliki Nor Zarifah , Cui Heng
Published: January 2025

Resilient design, as a strategy to address various disruptions and pressures, remains poorly understood among the public, which hinders its effectiveness. This study aims to explore how physical elements in urban form, environmental stimuli, and individual attributes influence public perception of resilient design characteristics. A video questionnaire survey was conducted to investigate these perceptions. Results indicate that physical elements—such as road signs, social service facilities, road infrastructure, accessibility to the center, accessible green spaces, diversified activity areas, and disability facilities—negatively impact public perception of resilient design. Conversely, environmental stimuli, including fast/slow, qualitative/quantitative, and short-term changes, positively influence these perceptions. Additionally, the findings reveal that older individuals, those with lower levels of education, and individuals who have had contact with the area for less than three years exhibit weaker perceptions of resilient design characteristics. The study proposes strategies for optimizing resilient design from the perspectives of physical elements and environmental stimuli, while also recommending that future research focus on groups with limited perceptions of resilient design characteristics.
Population-Level SARS-CoV-2 RT–PCR Cycle Threshold Values and Their Relationships with COVID-19 Transmission and Outcome Metrics: A Time Series Analysis Across Pandemic Years
Authors: De Arcos-Jiménez Judith Carolina , Quintero-Salgado Ernestina , Martínez-Ayala Pedro , Rosales-Chávez Gustavo , Damian-Negrete Roberto Miguel , Fernández-Diaz Oscar Francisco , Ruiz-Briseño Mariana del Rocio , López-Romo Rosendo , Vargas-Becerra Patricia Noemi , Rodríguez-Montaño Ruth , López-Yáñez Ana María , Briseno-Ramirez Jaime
Published: January 2025

This study investigates the relationship between SARS-CoV-2 RT–PCR cycle threshold (Ct) values and key COVID-19 transmission and outcome metrics across five years of the pandemic in Jalisco, Mexico. Utilizing a comprehensive time-series analysis, we evaluated weekly median Ct values as proxies for viral load and their temporal associations with positivity rates, reproduction numbers (Rt), hospitalizations, and mortality. Cross-correlation and lagged regression analyses revealed significant lead–lag relationships, with declining Ct values consistently preceding surges in positivity rates and hospitalizations, particularly during the early phases of the pandemic. Granger causality tests and vector autoregressive modeling confirmed the predictive utility of Ct values, highlighting their potential as early warning indicators. The study further observed a weakening association in later pandemic stages, likely influenced by the emergence of new variants, hybrid immunity, changes in human behavior, and diagnostic shifts. These findings underscore the value of Ct values as scalable tools for public health surveillance and highlight the importance of contextualizing their analysis within specific epidemiological and temporal frameworks. Integrating Ct monitoring into surveillance systems could enhance pandemic preparedness, improve outbreak forecasting, and strengthen epidemiological modeling.
Conversion to Glaucoma After Ocular Trauma in Pediatric Patients
Authors: Cardakli Nur , Gore Rujuta A. , Kraus Courtney L.
Published: January 2025

Background: The outcomes of pediatric glaucoma suspects with a history of ocular trauma remains unknown; we describe the rate of conversion to glaucoma of this population of patients at a research-intensive academic center. Methods: We conducted a retrospective case series of pediatric patients with a history of open- or closed-globe trauma who were being monitored as pediatric glaucoma suspects at the Wilmer Eye Institute between 2005 and 2016. Results: A total of 62 eyes from 62 patients with a history of ocular trauma were identified with a median age at presentation of 9.7 years (7.8 years) and a median follow-up of 2.7 (5.8 years). There were 29 eyes (46.8%) with open-globe injuries and 33 eyes (53.2%) with closed-globe injuries. A higher proportion of eyes that sustained closed-globe injuries were started on topical therapy for persistent ocular hypertension than eyes that sustained open-globe injuries (36.4% versus 10.3%, X2 = 5.6976, p = 0.017). Five eyes (8.1%) developed glaucoma during the follow-up period, all of which had a history of closed-globe injury (15.2%, X2 = 4.7794, p = 0.029). Four eyes of these eyes underwent glaucoma-related surgical intervention. Most eyes (3/5, 60%) that went on to develop post-traumatic glaucoma had undergone additional and/or concurrent intraocular surgical interventions to address sequelae of ocular trauma, such as traumatic cataract and retinal detachment. Conclusions: All eyes that developed glaucomatous damage or underwent glaucoma-related surgical intervention in this cohort of patients with a history of ocular trauma were those that had sustained close-globe injuries. No eyes that sustained open-globe injury progressed to glaucoma.
Pathogenesis and symptomatic therapy of cystic fibrosis
Authors:   Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), Moscow, Russia, Demidova A. D. , Zavadskiy S. P. ,   Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), Moscow, Russia
Published: January 2025

The purpose of this work is to study the prospects for using gene
therapy drugs for the treatment of cystic fibrosis. The authors set the task of
collecting the pathogenesis, symptoms, and prognosis of the disease, and
studying the currently available therapy for cystic fibrosis and its effectiveness.
Effect of Cutting Gases on the Hardness of Thermally Cut High Strenght Steels
Authors: Kuti János , Fábián Enikő Réka , Gáti József
Published: January 2025

In this work, it was illustrating the consequences of flame cutting on XAR® 400 and S960Q type high-strength
steels. During flame cutting, the metal, locally heated to ignition temperature, burns in the oxygen beam and
removes the resulting combustion product from the kerf. As a result of the process, chemical and physical
changes occur in the microstructure of the steel, which can have a significant effect on its properties. Examining the microstructural transformations due to flame cutting of high-strength steels is essential from
the point of view of proper design and production. In case of XAR® 400 steel quality, increasing the cutting
oxygen significantly changes the microstructure, with a high reduction in hardness in the heat affected zone
at cutting zone. For S960Q steel, flame cutting does not cause a drastic change in the microstructure of steel,
and increasing the amount of cutting oxygen does not significantly change the hardness.
КОГНИТИВНЫЙ ИНСТРУМЕНТАРИЙ СЕТЕВОГО ДИСКУРСА (ЭКСПЕРТИЗА ВИДЕОСЮЖЕТА О РОССИЙСКО-УКРАИНСКОМ ВООРУЖЕННОМ КОНФЛИКТЕ)
Authors: Мельник Г.С.
Published: January 2025

The article is devoted to the linguistic and psychological examination of a typical video using cognitive tools that form a negative image of Russia, the President, the Armed Forces of the Russian Federation, and the Russian people in the online audience. Keywords: video; information security; cognitive tools; psychological methods of influence; information environment.
L'enseignement de la statistique: où, quand, comment, pourquoi pas ?
Authors: Gattuso Linda
Published: January 2025

L’importance de la statistique est largement admise et son utilisation est répandue. Pour éviter son emploi inadéquat sinon erroné, il serait nécessaire d’inclure son enseignement dans la formation, mais où, quand et comment ? Toutes ces questions sont interreliées. Où : dans un contexte de transfert des compétences, il n’est pas exclu que la statistique soit présente en géographie, en économie ou encore en physique par exemple, là où l’on trouve des données. Toutefois, le plus souvent, s’il se trouve à l’école, l’enseignement de la statistique s’insère dans le cours de mathématiques. Quels sont les avantages et inconvénients de cette situation ? Quand : à quel moment peut-on le faire, à l’école ou vaudrait-il mieux attendre l’université ? Quand les élèves sont-ils prêts à comprendre les concepts de la statistique ? Quel que soit l’endroit ou le moment, il reste qu’il faut se demander comment cet enseignement doit être fait. Un enseignement de la statistique favorisant le développement de la pensée statistique et la construction de concepts de base comme ceux de variabilité, de distribution, peut commencer sans l’utilisation a priori de développements mathématiques formels. Le développement de la pensée et du raisonnement statistique passe par l’expérimentation du parcours du statisticien, en bref, questionnement, collecte de données, analyse et conclusion. De plus, l’apprentissage doit se faire en tenant compte des acquis (plus ou moins conscients) de l’apprenant. Reste la question du «Pourquoi pas ? ». Quels sont aujourd’hui les obstacles freinant l’essor de l’enseignement de la statistique ? Nous tenterons de répondre à toutes ces questions tout en apportant quelques suggestions de solution.
L'enseignement à distance en statistique et l'usage de logiciels au travers de deux exemples
Authors: Jutand Marthe-Aline , Ruiz-Gazen Anne
Published: January 2025

Since ten years, the e-learning in statistics has been developed not only for statisticians but for very different learners’ profiles. The implementation of these programs requires particular thinking because the students are isolated and generally not fully available. It is therefore necessary to consider the choice of software to obtain the best result. The experiences of the ISPED-University Bordeaux Segalen formations (University diploma and public health master) and the University Toulouse 1 Capitole are presented as possible approaches.
Un contrôle surprise... pour l'enseignant ! L'évaluation comme révélateur des préconceptions de la statistique chez les étudiants
Authors: Bihan-Poudec Alain
Published: January 2025

Ces propos au sujet d’une expérience d’enseignement partent d’une orientation et d’une conviction. Une orientation : inscrire la statistique dans le quotidien des apprenants ; une conviction : être à l’écoute de ces derniers pour optimiser l’enseignement et in fine l’apprentissage de la statistique. L’occasion en est donnée par un contrôle auprès d’étudiants en Licence en Sciences de l’Éducation. Les questions ouvertes laissaient voir un arrière-plan de préjugés et de conceptions erronées. Ainsi, les verbatim font-ils apparaître déni de la variabilité dans les échantillons, nécessité de données quantitatives pour évaluer, croyance dans la nécessité d’une précision maximale, etc. Ces observations confortent la nécessité pour l’enseignant d’identifier les conceptions clandestines des étudiants.
La bibliothèque et les archives de l’Insee
Authors: Groudiev Stéphanie , Saboulin Michel de
Published: January 2025

Le site www. insee. fr assure aujourd’hui l’essentiel de la diffusion des informations produites par l’Institut national de la statistique et des études économiques (Insee). Mais la rubrique “Publications” du site insee.fr ne contient que des publications relativement récentes, issues d’une édition en ligne. Un grand nombre de publications actuelles et anciennes sont accessibles grâce à la bibliothèque de l’Insee, et des dossiers archivés au Service des archives économiques et financières (SAEF) donnent des informations précieuses sur l’Insee et les organismes qui l’ont précédé avant sa création en 1946 (encadré).
Regeneration of a Rabbit Segmental Defect with a New Bone Therapy: Autologous Blood Coagulum with Bone Morphogenetic Protein 6 and Synthetic Ceramics
Authors: Stokovic Nikola , Ivanjko Natalia , Javor Ana , Pecin Marko , Muzina Katarina , Stepanic Zeljka Magdalena , Capak Hrvoje , Vrbanac Zoran , Maticic Drazen , Vukicevic Slobodan
Published: January 2025

Segmental defects of long bones are among the most challenging and debilitating conditions in clinical medicine. Osteogrow-C is a novel osteoinductive device composed of recombinant human bone morphogenetic protein 6 (rhBMP6) delivered within autologous blood coagulum (ABC) with calcium phosphate ceramics that was proven efficacious in preclinical models of spinal fusion. This study aimed to evaluate the efficacy of Osteogrow-C in comparison to that of other osteoinductive therapies in a clinically relevant segmental defect model in rabbits. Segmental defects (15 mm) of rabbit ulna were treated with Osteogrow-C containing different synthetic ceramic particles (tricalcium phosphate [TCP] and TCP/hydroxyapatite 40%/60%), Osteogrow (rhBMP6/ABC), Infuse (rhBMP2/absorbable collagen sponge), and control implants without bone morphogenetic proteins. Defect healing was evaluated by in vivo x-ray scans 4, 8, and 17 weeks after the surgery, and animals were killed after 17 weeks for further radiographical and histological assessment. Evaluation of x-ray images, micro-computed tomography, and histological sections revealed that both Osteogrow-C formulations as well as Osteogrow and Infuse promoted healing of the ulnar segmental defect. However, radiographic scores were higher in animals treated with Osteogrow-C than those for the other used therapies. Moreover, evaluation of in vivo x-ray scans revealed that Osteogrow-C with TCP ceramics induced the most rapid defect bridging. On the other hand, control implants (ABC/TCP and ABC/biphasic calcium phosphate) promoted limited osteogenesis without defect bridging. The findings of this study suggest that Osteogrow-C is a promising safe therapeutic solution for the treatment of large bone defects, providing relief to millions of patients suffering from this debilitating condition.
Novel lncRNA LncMSTRG.11341.25 Promotes Osteogenic Differentiation of Human Bone Marrow Stem Cells via the miR-939-5p/PAX8 Axis
Authors: Ni Feifei , Li Jianjun , Yin Qin , Chen Yangyang , Shao Zengwu , Wang Hong
Published: January 2025

Human bone marrow stem cells (hBMSCs) play an important role during the fracture healing phase. Previous clinical studies by our research group found that fracture healing time was obviously delayed in patients who underwent splenectomy, for combined traumatic fractures and splenic rupture, which is most likely related to the dysregulation of immune inflammatory function of the body after splenectomy. A large number of studies have reported that the inflammatory factor interleukin-1β plays an important role in the multi-directional differentiation ability and immune regulation of BMSC, but its specific regulatory mechanism needs to be further studied. Recently, long noncoding RNAs (lncRNAs) have attracted remarkable attention owing to their close relationship with stem cell osteogenesis and potential role in various bone diseases. In this study, we explored the molecular mechanism of a novel lncRNA, LncMSTRG.11341.25 (LncMSTRG25), in terms of its effects on osteogenic differentiation of hBMSCs. Our results reveal significant up-regulation of LncMSTRG25, osteogenic differentiation markers during the osteogenic differentiation of hBMSCs, and decreased expression of miR-939-5p with an increase in differentiation time. LncMSTRG25 knockdown significantly inhibited the osteogenic ability of hBMSCs. When we knocked down PAX8 alone, we found that the osteogenic ability of hBMSCs was also significantly reduced. The interaction between LncMSTRG25 and PAX8 was verified using the RNA immunoprecipitation assay, RNA pull-down assays, silver staining, and the dual-luciferase reporter. The results show that LncMSTRG25 can function as a sponge to adsorb miR-939-5p, inducing the osteogenic differentiation of hBMSCs by activating PAX8. These findings deepen our understanding of the regulatory role of lncRNA–miRNA–mRNA networks in the immune microenvironment of bone marrow, and highlight the important role played by the spleen as an immune organ in fracture healing.
A Design Thinking-Based Study on Walking Aids for the Elderly Applying Universal Design Principles: Focusing on Rollators
Authors:   Korean Aging-Frendly Ind Assoc, Ko Daeh-Yun , Bae Ye-Na
Published: January 2025

Objective : This study aims to explore the potential for developing walker designs that simultaneously address the physical comfort and psychological well-being of older adults in preparation for South Korea's transition into a super-aged society. To achieve this, the study applies the seven principles of universal design and the design thinking process to reflect the diverse needs of older adults. It proposes a design that seeks to enhance mobility and promote autonomy.
Methods : This study conducted observational research and interviews with 13 individuals aged 65 and older from May to June 2024. The interview questions were developed based on physical and psychological analysis elements identified in previous studies, as well as the seven principles of universal design. The data collected was analyzed, and the design improvement process was carried out using the five-stage model of design thinking from d.school.
Results : Based on the participants' real-life experiences, as well as their physical and psychological discomforts and sources of anxiety, this study applied the seven principles of universal design to the walker and conducted the design thinking process. By following the stages of 'Empathize', 'Define', 'Ideate', 'Prototype', and 'Test' the study derived conclusions and suggested directions for design improvement in walker development. The analysis prioritized reducing shoulder and wrist strain through adjustments in handle angles and brake structure, while enhancing psychological well-being through the inclusion of safe storage space and an intuitive folding mechanism. A design proposal reflecting these improvements was presented.
Conclusion: This study emphasizes the necessity of walker designs that reflect the specific needs of older adults in preparation for the transition into a super-aged society. By combining the principles of universal design with a user-centered design thinking process, a walker was developed that allows older adults to experience both physical and psychological comfort. The study highlights the importance of design approaches that consider not only the physical comfort but also the psychological well-being of older adults. It further suggests the need for designs that incorporate the real-world needs of users in the development of future products for the aging population.
HEC-RAS simulation of scour in circular piers using a sediment transport demonstration channel
Authors: Chávez-Cárdenas Xavier , Gutiérrez-Villalobos José Marcelino , Moralez-Garibay María Cristina
Published: January 2025

Intending to take advantage of the implementation of two very affordable resources, a sediment
transport demonstration channel for teaching and a very versatile open-source software (HECRAS), the present work develops the numerical simulation of the scour in a circular pier. The
numerical modeling (HEC-RAS) was calibrated with the tests of the physical model (sediment
transport demonstration channel). The reduced dimensions of the channel limited the number and
precision of the tests; however, they were sufficient to provide the information required by the
numerical model. The work details the physical and numerical modeling in such a way that a clear
and simple guide is obtained, to simulate the scour of piers in bridges. The result obtained in the
first instance exceeds the scour of the physical model, however, due to the simulated conditions,
very close to a wide pier in shallow flow, the overestimation was expected.
La interpretación de análisis en Agronomía. Análisis de suelo (parte 1)
Authors: García López Ana María , Nieto Cantero Juan , Becerra Vela Isabel María , Pérez Picón María , Moreno Aguirre María Teresa , Carmona Chiara Eusebio , Recena Garrido Ramiro , Delgado García Antonio , Quintero Ariza José Manuel
Published: January 2025

Estos vídeos educativos estás diseñados para facilitar la comprensión e interpretación de los análisis de suelo, agua y planta más usuales en agronomía, conceptos claves de las asignaturas de Principio de Producción Vegetal y Fitotecnia General en el Grado en Ingeniería Agrícola. En este primer video se muestra las técnicas para realizar un correcto muestreo de suelo, así como parámetros fundamentales como textura, materia orgánica y capacidad de intercambio catiónico de los suelos. Se incluyen esquemas y diagramas para interpretar los resultados y los valores habituales en suelos agrícolas.

Este video educativo va dirigido al público en general con especial atención al alumnado de asignaturas relacionadas con las ciencias agronómicas.

Mediante esto recurso audiovisual, el vídeo muestra los principales análisis químicos de suelos, su metodología y claves para una buena interpretación de los resultados.
ТЕОРЕТИЧЕСКИЕ ПОДХОДЫ И АСПЕКТЫ К ИССЛЕДОВАНИЮ ПРОСТРАНСТВЕННОГО РАЗВИТИЯ ГОРОДСКИХ ТЕРРИТОРИЙ
Authors: Иванов Роман Николаевич , Рубцов Владимир Анатольевич
Published: January 2025

Исследование пространственных структур городов определяется происходящими изменениями в системе методов регулирования их развития и активизацией процессов урбанизации, поиском инструментов повышения уровня и качества жизни городского населения. Проблемы развития территорий тесно соотносятся с вопросами роста городского населения, развития и увеличения крупных городов, а также агломераций разного порядка. Изучение основных аспектов развития теорий и моделей размещения производительных сил и расселения дает более глубокое представление о проблемах развития городских территорий, решение которых позволяет повысить качество к подготовке документов территориального планирования и градостроительного зонирования, а также дает инструменты для грамотного выстраивания стратегий социально-экономического развития территорий. В ходе изучения основных теорий авторы уделяют особое внимание процессам развития и трансформации городских территорий, которые привели к формированию особого типа моделей пространственных структур городов - моноцентрической и полицентрической. Данный этап работы в дальнейшем позволит авторам более комплексно подойти к разработке основных направлений и рекомендаций по формированию пространственной структуры городов.

The study of spatial structures of cities is determined by the ongoing changes in the system of methods of regulation of their development and activation of processes of urbanization, search for tools to improve the level and quality of life of the urban population. The problems of territorial development are closely related to the growth of the urban population, the development and expansion of large cities, as well as agglomerations of different order. Given that the growth of the largest cities of Russia is actively continuing, the problem of developing competent solutions in the field of spatial planning is one of the priority tasks. The study of the problems of placement of productive forces, territorial planning, analysis of the theories of spatial development and settlement gives a deeper insight into the problem, the solution of which allows to improve the quality of the preparation of documents of territorial planning and urban zoning. In addition, the attribute properties of the polycentric model of urban space organization, which is characterized by the network (horizontal) territorial structure, when each of the urban structures (districts or territorial units) are equal, independent and are connected by cooperation relations, which is a prerequisite for the complex development of each of the territorial units and for the process of decentralization of the existing model of space organization.
Implementasi Business Model Canvas (BMC) dalam Perencanaan Strategi Pemasaran Kewirausahaan UMKM (Studi pada “Citra Oleh-Oleh Lampung” di Bandar Lampung)
Authors: Daud Syahril , Al Affan Dhalvi , Rachman Muhammad Farel , Al Fiqih Muhammad Rizvy
Published: January 2025

This study aims to apply the Business Model Canvas (BMC) as a strategic tool in designing marketing strategies to increase the competitiveness and sales of Toko Citra Oleh-Oleh Lampung, an MSME engaged in the field of regional souvenirs. The research method used is descriptive qualitative, with data collection through in-depth interviews, direct observation, and literature studies. Data analysis uses a thematic approach supported by SWOT analysis to identify strengths, weaknesses, opportunities, and threats in the business. The results of the study show that the main elements in the BMC, such as Customer Segments, Value Propositions, and Channels, play a significant role in determining an effective marketing strategy. Lampung's typical products with local cultural values, distributed through physical and digital stores, and a focus on customer experience are the main advantages. However, the study also identified challenges, such as dependence on tourists and logistical constraints, which need to be addressed through product diversification, digital marketing optimization, and operational efficiency. This study provides a practical contribution to Toko Citra Oleh-Oleh Lampung in increasing its competitiveness in the local and national markets. In addition, the results of this study are expected to be a reference for other MSMEs in facing competition in the era of globalization. Suggestions for further research are to conduct a comparative study between MSMEs that implement BMC and those that do not, to show the effectiveness of this strategy in more depth.
The Strategic Path of Russia in Eurasia
Authors: Samay M. Ali
Published: January 2025

The transformation of the bipolar world order into unilateral or American globalization began following the collapse of the Soviet Union. Ever since, the regions, countries, and markets of the world have been bizarrely interconnected with American economy and politics. Within this model, the US has become the centre of the world security, political and economic affairs. The re-emergence of Russia in the early 21th century raised the geopolitical and geo-economic importance of the entire Eurasian continent. China, India, Turkey, and Iran have coordinated some of their interests with Russia. These Eurasian powers are likely to create a common or shared geopolitical and geo-economic dominance in the region. This paper posits the hypothesis that Russian Eurasianist foreign policy strategy implies a comprehensive regional security, including political and economic cooperation initiatives by applying global partnership theory instead of heartland and rimland theory. It seeks an answer to the question of how Russia can shape a multi-vector diplomacy to convince the Eurasian great, middle and small powers to cooperate and coordinate their policies.
The emergency doctor employment helicopter project. Design in rescue medicine in Germany.
Authors: Schedler Olaf
Published: January 2025

The emergency doctor employment helicopter (NEH) project was began in September 1995 in order of district administration Bad Doberan (DBR) to rescue medical care. The helicopter staff manages 1134 actions annually in average. In the case of 96 percent of all operations flown in a time limit of rescue of 10 minutes is managed. 97,4 percent of emergency operations are flown without any difficulties. The medical equipment is equivalent with emergency ambulance (NEF). The patients transportation in NEH is not practicable. The patients profile represents life rescue with a plain share of accidents and injuries. With the help of stated results the high efficiency and effectivity of the fast medical help of life rescue with the doctor employment helicopter could be proved for this geographical area.