bluuebunny/crossref_metadata_2025 huggingface dataset:
Combination of Oncolytic Measles Virus and Ursolic Acid Synergistically Induces Oncolysis of Hepatocellular Carcinoma Cells
Authors: Liu Ching-Hsuan , Tai Chen-Jei , Kuo Yu-Ting , Chang Shen-Shong , Lin Liang-Tzung
Published: May 2023

Hepatocellular carcinoma (HCC) remains a difficult-to-treat cancer due to late diagnosis and limited curative treatment options. Developing more effective therapeutic strategies is essential for the management of HCC. Oncolytic virotherapy is a novel treatment modality for cancers, and its combination with small molecules merits further exploration. In this study, we combined oncolytic measles virus (MV) with the natural triterpenoid compound ursolic acid (UA) and evaluated their combination effect against HCC cells, including those harboring hepatitis B virus (HBV) or hepatitis C virus (HCV) replication. We found that the combination of MV and UA synergistically induced more cell death in Huh-7 HCC cells through enhanced apoptosis. In addition, increased oxidative stress and loss of mitochondrial potential were observed in the treated cells, indicating dysregulation of the mitochondria-dependent pathway. Similar synergistic cytotoxic effects were also found in HCC cells harboring HBV or HCV genomes. These findings underscore the potential of oncolytic MV and UA combination for further development as a treatment strategy for HCC.
Infectious Bursal Disease Virus Assembly Causes Endoplasmic Reticulum Stress and Lipid Droplet Accumulation
Authors: Frontini-López Yesica R. , Rivera Lautaro , Pocognoni Cristian A. , Roldán Julieta S. , Colombo María I. , Uhart Marina , Delgui Laura R.
Published: May 2023

Gumboro illness is caused by the highly contagious immunosuppressive infectious bursal disease virus (IBDV), which affects the poultry industry globally. We have previously shown that IBDV hijacks the endocytic pathway to construct viral replication complexes on endosomes linked to the Golgi complex (GC). Then, analyzing crucial proteins involved in the secretory pathway, we showed the essential requirement of Rab1b, the Rab1b downstream effector Golgi-specific BFA resistance factor 1 (GBF1), and its substrate, the small GTPase ADP-ribosylation factor 1 (ARF1), for IBDV replication. In the current work, we focused on elucidating the IBDV assembly sites. We show that viral assembly occurs within single-membrane compartments closely associated with endoplasmic reticulum (ER) membranes, though we failed to elucidate the exact nature of the virus-wrapping membranes. Additionally, we show that IBDV infection promotes the stress of the ER, characterized by an accumulation of the chaperone binding protein (BiP) and lipid droplets (LDs) in the host cells. Overall, our results represent further original data showing the interplay between IBDV and the secretory pathway, making a substantial contribution to the field of birnaviruses–host cell interactions.
The Tumor-Specific Immune Landscape in HPV+ Head and Neck Cancer
Authors: Conarty Jacob P. , Wieland Andreas
Published: May 2023

Human papillomaviruses (HPVs) are the causative agent of several anogenital cancers as well as head and neck cancers, with HPV+ head and neck squamous cell carcinoma (HNSCC) becoming a rapidly growing public health issue in the Western world. Due its viral etiology and potentially its subanatomical location, HPV+ HNSCC exhibits an immune microenvironment which is more inflamed and thus distinct from HPV-negative HNSCC. Notably, the antigenic landscape in most HPV+ HNSCC tumors extends beyond the classical HPV oncoproteins E6/7 and is extensively targeted by both the humoral and cellular arms of the adaptive immune system. Here, we provide a comprehensive overview of HPV-specific immune responses in patients with HPV+ HNSCC. We highlight the localization, antigen specificity, and differentiation states of humoral and cellular immune responses, and discuss their similarities and differences. Finally, we review currently pursued immunotherapeutic treatment modalities that attempt to harness HPV-specific immune responses for improving clinical outcomes in patients with HPV+ HNSCC.
Identification by Reverse Vaccinology of Three Virulence Factors in Burkholderia cenocepacia That May Represent Ideal Vaccine Antigens
Authors: Irudal Samuele , Scoffone Viola Camilla , Trespidi Gabriele , Barbieri Giulia , D’Amato Maura , Viglio Simona , Pizza Mariagrazia , Scarselli Maria , Riccardi Giovanna , Buroni Silvia
Published: May 2023

The Burkholderia cepacia complex comprises environmental and clinical Gram-negative bacteria that infect particularly debilitated people, such as those with cystic fibrosis. Their high level of antibiotic resistance makes empirical treatments often ineffective, increasing the risk of worst outcomes and the diffusion of multi-drug resistance. However, the discovery of new antibiotics is not trivial, so an alternative can be the use of vaccination. Here, the reverse vaccinology approach has been used to identify antigen candidates, obtaining a short-list of 24 proteins. The localization and different aspects of virulence were investigated for three of them—BCAL1524, BCAM0949, and BCAS0335. The three antigens were localized in the outer membrane vesicles confirming that they are surface exposed. We showed that BCAL1524, a collagen-like protein, promotes bacteria auto-aggregation and plays an important role in virulence, in the Galleria mellonella model. BCAM0949, an extracellular lipase, mediates piperacillin resistance, biofilm formation in Luria Bertani and artificial sputum medium, rhamnolipid production, and swimming motility; its predicted lipolytic activity was also experimentally confirmed. BCAS0335, a trimeric adhesin, promotes minocycline resistance, biofilm organization in LB, and virulence in G. mellonella. Their important role in virulence necessitates further investigations to shed light on the usefulness of these proteins as antigen candidates.
Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Vaccine Formulations Targeting Rabbit Hemorrhagic Disease Virus Are Immunogenic and Efficacious
Authors: Akache Bassel , Read Andrew J. , Dudani Renu , Harrison Blair A. , Williams Dean , Deschatelets Lise , Jia Yimei , Chandan Vandana , Stark Felicity C. , Agbayani Gerard , Makinen Shawn R. , Hemraz Usha D. , Lam Edmond , Régnier Sophie , Zou Wei , Kirkland Peter D. , McCluskie Michael J.
Published: May 2023

Vaccines play an important role in maintaining human and animal health worldwide. There is continued demand for effective and safe adjuvants capable of enhancing antigen-specific responses to a target pathogen. Rabbit hemorrhagic disease virus (RHDV) is a highly contagious calicivirus that often induces high mortality rates in rabbits. Herein, we evaluated the activity of an experimental sulfated lactosyl archaeol (SLA) archaeosome adjuvant when incorporated in subunit vaccine formulations targeting RHDV. The subunit antigens consisted of RHDV–CRM197 peptide conjugates or recombinant RHDV2 VP60. SLA was able to enhance antigen-specific antibody titers and cellular responses in mice and rabbits. Three weeks following immunization, antigen-specific antibody levels in rabbits vaccinated with RHDV2 VP60 + SLA were significantly higher than those immunized with antigen alone, with geomean titers of 7393 vs. 117. In addition, the SLA-adjuvanted VP60-based formulations were highly efficacious in a rabbit RHDV2 challenge model with up to 87.5% animals surviving the viral challenge. These findings demonstrate the potential utility of SLA adjuvants in veterinary applications and highlight its activity in different types of mammalian species.
Paleohydraulics and Complexity Theory: Perspectives on Self Organization of Ancient Societies
Authors: Ortloff Charles R.
Published: May 2023

Complexity theory provides a path toward understanding the development of ancient Andean societal progress from early settlements to later high population states. The use of modern hydraulic engineering methods to develop an understanding of the technical achievements of ancient societies (paleohydraulics), when combined with complexity theory, provides a path toward understanding the role of hydraulic engineering achievements to guide population increase and societal group cooperation on the path from early kin settlements to later statehood. An example case illustrating the paleohydraulics-complexity theory connection is presented for advancement of the pre-Columbian Bolivian Tiwanaku (600–1100 CE) society through their seasonal control of groundwater levels in urban city areas. This feature provided well water availability for city housing, public fountains, city hygienic and health benefits from the control of habitation dampness levels, water on a year-round basis for intra-city specialty crops, and the structural foundational stability of monumental religious structures. Commensurate with this application, Tiwanaku raised-field systems utilized groundwater control technologies to support multi-cropping agriculture to support growing population demands. Paleohydraulics theory together with complexity theory is applied to other major South American ancient societies (Caral, Tiwanaku, Chimú, Wari, Inka) to illustrate the influence of advanced hydraulic engineering technologies on advances from early origins to statehood.
Debris Flow Run-Out Prediction Based on the Shallow-Water Flow Numerical Model—A Case Study of Xulong Gully
Authors: Liu Yaowu , Zhang Dongsheng , Guo Decun , He Wantong , Zhang Weiheng
Published: May 2023

Here we present a method for predicting debris flow run-out based on a numerical model for shallow water flows, using a case study conducted on Xulong Gully, a proposed dam site for a hydropower station in the upper reaches of the Jinsha River. A field investigation and remote sensing interpretation methods were used to develop a comprehensive evaluation of debris flow zones and calculate the potential provenance volume in the Xulong Gully. Particle-size analysis was conducted on the early debris flow fan in the Xulong Gully to determine the rheological properties of the debris flow materials. A numerical model for shallow flows was constructed using the finite volume method to verify fluid motion across complex terrain and explore the debris flow run-out range with various provenance volumes. The model showed that for a total debris flow volume of less than two million m3, the debris flow impact area would remain within the Xulong Gully. However, if the total debris flow volume is more than two million m3, the debris flow would flush out into the Jinsha River, blocking a portion of the river. If all the provenance in the Xulong Gully were flushed out, the maximum flow velocity of the generated debris flow would be 11 m/s and the thickness of the debris flow at the Xulong Gully estuary would be about 28.8 m. The debris flow would completely block 470 m of the Jinsha River.
Experimental Study on the Wake Characteristics of Composite Secondary Grooved Cylinder
Authors: Liu Liangqing , Luo Xiaoyuan , Wang Jianzheng , Shi Zhisai , Yan Fei
Published: May 2023

Flow around cylinders is widespread in marine engineering projects such as marine risers, marine pipelines, and tension leg. To understand the wake characteristics of the circular cylinder with different roughness, at a Reynolds number of 7400, a circulation water tunnel is used for experimental PIV measurements to compare the wake characteristics among the smooth cylinder, the original grooved cylinder, and the secondary grooved cylinder. The results revealed that the secondary grooved reduced the recirculation region, the flow-direction velocity gradient, the Reynolds shear stresses, and turbulent kinetic energy. Both small-scale and large-scale vortices are present in the wake vortex shedding. The instantaneous large-scale vortices behind the grooved cylinders are dispersed into several relatively small-scale vortices. Furthermore, the spike of the secondary grooved cylinder is a vortex generator, and directly impacts the generation of small eddies and the dissipation of large vortices.
Enhanced Photocatalytic Degradation of the Antidepressant Sertraline in Aqueous Solutions by Zinc Oxide Nanoparticles
Authors: Mohamed Zeinhom H. , Riyad Yasser M. , Hendawy Hassan A. , Abdelbary Hassan M. H.
Published: May 2023

Antidepressants are one of the main pollutants in the aquatic environment. They are being widely studied due to their widespread use, possible health effects, and partial removal from wastewater treatment plants by conventional methods. Photocatalysis is an effective and ecologically beneficial method in wastewater treatment. In the present study, the photocatalytic degradation of sertraline hydrochloride (SERT) in water using nano-sized zinc oxide (ZnO-NPs) was investigated. The ZnO-NPs were synthesized from zinc gluconate as a precursor by the sol–gel method. The crystal structure, morphology, surface charge, and textural properties were characterized by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray analyses, transmission electron microscopy, Fourier-transform infrared spectroscopy, zeta potential, and N2 adsorption–desorption measurements. The removal of SERT in water was explored by different processes: H2O2/UV, ZnO-NPs/H2O2/UV, and ZnO-NPs/UV. Our results indicate that the combination of both UV illumination and the ZnO-NP as a catalyst was necessary for the efficient degradation of the drug. Nearly complete removal of SERT (98.7%) was achieved in 30 min with the ZnO-NPs/UV process at room temperature. The photodegradation of SERT follows first-order kinetics with a rate constant of 0.0678 min−1. The results reveal that SERT degradation with ZnO-NPs/UV is pH-dependent, as the maximum drug removal was achieved at pH 11. Initial drug concentration, catalyst dose, and hydrogen peroxide concentration were also crucial in the removal of SERT. Our findings indicate that the high specific surface area and porous structure of ZnO-NP enhance its photocatalytic performance toward photodegradation of SERT, i.e., ZnO-NP is an efficient nanophotocatalyst for the degradation of SERT under UV irradiation.
Study on the Treatment of Simulated Recirculating Mariculture Wastewater by Thiosulfate-Based Autotrophic Denitrification
Authors: Gao Fan , Yu Ting , Chen Zhongtai , Zhang Junbo , Xu Huchun , Xu Guangjing , Zhang Cuiya
Published: May 2023

In this study, a sulfur-based autotrophic denitrifying filter (SADF) was developed for the purpose of removing nitrate from simulated recirculating mariculture wastewater. Results showed that over 90% of the nitrate could be effectively eliminated by utilizing thiosulfate as the electron donor, with a molar ratio of thiosulfate-S to nitrate molar ratio of 2:1 or greater. Additional batch tests confirmed that thiosulfate was a suitable sulfur source for nitrate removal even without prior accumulation of the biomass to nitrite. Excess thiosulfate had a minor impact on N-removal efficiency, so an external sulfur source was not required for nitrate removal, however, it could still help to reduce nitrate accumulation and water replacement to some extent. High-throughput sequencing results illustrated that Thiomicrospira and Thioalkalivibrio were the dominant autotrophic denitrifying genera in the SADF, while Thiomicrospira was more significantly affected in the case of insufficient sulfur sources. As the issue of nitrate accumulation in the mariculture recirculating system has been resolved, only a small amount of water needs to be added to the system daily. Therefore, the thiosulfate-based SADF process has the potential to be implemented for nitrate removal in mariculture systems, which could present a promising sustainable solution to the nitrate pollution issue.
Analysis of Runoff Changes in the Wei River Basin, China: Confronting Climate Change and Human Activities
Authors: Xu Ruirui , Gu Chaojun , Qiu Dexun , Wu Changxue , Mu Xingmin , Gao Peng
Published: May 2023

Abrupt runoff reduction in the Wei River Basin (WRB) has attracted extensive attention owing to climate change and human activities. Nevertheless, previous studies have inadequately assessed the respective contributions of climate variability and human activities to runoff change on different spatial scales. Using Mann–Kendall and Pettitt’s methods, this study identified long-term (1970–2018) changes in hydro-meteorological variables. Furthermore, the Budyko-based method was used to quantify the influence of climate change and human activities on runoff change at different spatial scales of the WRB, including the whole WRB, three sub-basins, and sixteen catchments. The results show that a significant decrease trend was identified in runoff at different spatial scales within the WRB. Runoff in almost all catchments showed a significant downward trend. Temperature, potential evapotranspiration, and the parameter n showed significant increases, whereas no significant trend in precipitation was observed. The change in runoff was mainly concentrated in the mid-1990s and early 2000s. Anthropogenic activities produced a larger impact on runoff decrease in the WRB (62.8%), three sub-basins (53.9% to 65.8%), and most catchments (–47.0% to 147.3%) than climate change. Dramatic catchment characteristic changes caused by large-scale human activities were the predominant reason of runoff reduction in the WRB. Our findings provide a comprehensive understanding of the dominate factors causing runoff change and contribute to water resource management and ecosystem health conservation in the WRB.
Optimizing the Pump Storage System for Hot Water Showering at Swimming Pools
Authors: Wong Ling-Tim , Chan Chun-San , Mui Kwok-Wai , Zhang Dadi
Published: May 2023

Previous studies have demonstrated the energy- and water-saving potentials of showering facilities in residential buildings. However, the prospect of public showering places where multiple showerheads usually worked together according to their opening hours has often been overlooked and rarely investigated. This study measured the water flow rate in a water supply pipe to understand the water-use patterns and water consumption of showering facilities in a swimming pool. The measurements were carried out on typical cold and warm days. The results showed that the average water consumption was 50.5 L/person in December (T = 19.7 °C) and 38.6 L/person in April (T = 24.5 °C). The fluctuation of the water flow rate demonstrated a water demand pattern for the showering facilities, where the maximum water flow rate was more than twice the average level, indicating inefficient working modes of the water supply pump. To improve the current situation, an appropriately sized water tank was suggested to be installed, which could ensure a more stable water flow rate in the main supply pipe, enhancing the water supply system efficiency and saving energy for the water pump. These results contribute to establishing the design data for optimizing water tank design in swimming pools or similar buildings with public showering demand and illustrate the energy-saving potential of water supply systems in showering facilities. Nevertheless, the results of this study are only based on theoretical calculations. More comprehensive field studies with a water tank are required to confirm these findings and better elucidate the effects.
PENENTUAN SEKTOR UNGGULAN PEREKONOMIAN KOTA BANDUNG GUNA MENDUKUNG PENYERAPAN TENAGA KERJA BERDASARKAN PDRB TAHUN 2017-2021
Authors: Fitriansyah Hadi
Published: May 2023

Pembangunan daerah secara umum mengacu pada kemampuan suatu pemerintah daerah untuk memberikan pelayanan kepada seseorang serta pengelolaan sumber daya ekonomi yang ada pada suatu daerah sebagaimana mestinya untuk kepentingan ekonomi lokal. Studi ini bertujuan penetuan sektor unggulan berdasarkan hasil analisis sektor basis dan non-basis yang dilakukan pada Kota Bandung, serta dikaitkan dengan topik seperti penyerapan tenaga kerja di Kota Bandung. Pada penelitian ini, jenis penelitian deskriptif kuantitatif serta metode analisis LQ dan SS. Output dari penelitian ini diperoleh bahwa hasil analisis bahwa nilai LQ pada bidang Informasi dan Komunikasi menunjukan trend yang meningkat dalam beberapa tahun terakhir Serta analisis Shift Share menunjukkan sektor Informasi dan Komunikasi memiliki nilai positif paling tinggi yaitu 0,58. Dalam hal penentuan bidang atau sektor Informasi dan Komunikasi sebagai sektor unggulan perekonomian di Kota Bandung, dikarenakan dengan nilai PDRB Kota Bandung dari tahun 2017-2021 menunjukkan trend yang meningkat setiap tahunnya. Pertumbuhan sektor ini akan terus meningkat, sebagai contoh penggunaan ojek online, belanja online, penggunaan media sosial, dan lain sebagainya. Dengan adanya kegiatan tersebut maka masyarakat Kota Bandung akan meningkat dalam penyerapan tenaga kerja lebih dari 60% untuk persentase sekarang.
Chronique. A propos d'EURALEX '94, ou Quelques remarques sens dessus dessous sur la sémantique lexicale actuelle
Authors: Kleiber Georges
Published: May 2023

Où en est la sémantique lexicale aujourd’hui ? Cet article ne prétend évidemment pas apporter une réponse complète à cette question. Passant en revue sens dessus dessous les articles traitant de la lexicologie exposés au Congrès EURALEX d’Amsterdam (1994), il fournit des aperçus intéressants sur l’état actuel des études sémantiques, dégage certaines de leurs principales orientations et, surtout, montre qu’en matière de polysémie les traitements actuellement en vogue, comme la théorie de la «coercion» de Pustejovsky, ne sont pas toujours les plus appropriées.
Wortschatzentwicklung und semantische Entwicklung im Grundschulalter
Authors: Schmidlin Regula
Published: May 2023

Die Entwicklung von Erzählfähigkeiten, Text-Kohärenz, Inferenz- und Interpretationsprozessen schlagt sich an der sich mit dem Alter der Kinder veränderten Lexik nieder. Vier lexikalische Aspekte der Wortschatzentwicklung im Grundschulalter werden dargelegt: die lexikalische Varianz, die im Schriftlichen höher ist als im Mündlichen und in beiden Modalitäten mit dem Alter ansteigt ; der altersabhängige sowie auf einzelne Wortarten bezogene Wortschatzzuwachs, bei dem vor allem im Bereich der Autosemantika eine Entwicklung vom Konkreten hin zum Abstrakten und vom Neutralen hin zum Evaluierenden zu beobachten ist ; schliesslich die sich mit dem Alter entwickelnde Inferenz-Kompetenz, die ein Kontinuum bildet von präsupponierendem über inferierendes hin zu interpretierendem und schliesslich fabulierendem Erzählen.
La négation à longue portée en français
Authors: Vuillaume Marcel
Published: May 2023

On trouve en français parlé contemporain des exemples surprenants de négation à longue portée. Ainsi, dans une émission télévisée consacrée au marché du travail, un chef d’entreprise a déclaré Aujourd’hui, on commence pas à travailler à dix-sept ans et on fait toute sa carrière dans la même entreprise pour signifier, non pas que personne ne commence à travailler à dix-sept ans et que tout le monde fait sa carrière dans la même entreprise, mais que, si on commence à travailler à dix-sept ans, on ne peut pas faire toute sa carrière dans la même entreprise. L’objet de cet article est de montrer, sur la base d’autres exemples du même genre, 1) que la négation à longue portée n’est possible que dans des situations où la version positive de la proposition complexe (p et q) que l’on réfute a déjà été énoncée ou, du moins, suggérée, 2) que, dans son principe, elle consiste à nier p pour présenter comme contrefactuel l’espace mental au sein duquel est conçue comme valide la relation entre p et q.
Prépositions et subordination en français
Authors: Muller Claude
Published: May 2023

Ce papier traite de l’interaction entre les prépositions et la subordination. Devant l’infinitif, à côté de de, on trouve parfois à avec une valeur prédicative propre, souvent modale, mais qui peut parfois remplacer de dans la fonction de complémenteur. Avec un temps fini, les mêmes prépositions et quelques autres ont la particularité d’exiger un complément nominal ce, qui semble signaler les prépositions prototypiques, sans valeur prédicative propre ; la complémentation directe en que, restreinte pratiquement à la paire à/de, semble orienter l’interprétation vers la causation ou la visée psychologique.
A travers et les autres mots de sa famille : grammaticalisation et polysémie
Authors: Plungian Vladimir A.
Published: May 2023

L’étude porte sur la famille des expressions avec l’élément travers : à travers [X], au travers [de X], en travers [de X], de travers. Les contextes où travers est employé comme substantif sont également pris en considération. Chaque expression est analysée dans l’ensemble de ses emplois représentés à l’aide des réseaux sémantiques. Etant donné que la valeur de départ remonte à la situation «l 'actant traverse un repère allongé», les points-clefs dans l’évolution sémantique des expressions sont reconstruits.
La préposition devant : invariance et variations
Authors: Thuillier François
Published: May 2023

Notre étude propose une description de certaines caractéristiques de la préposition devant (formulables en termes de relation orientée), que l'on articule à l’analyse de phénomènes généraux, liés aux modes de contextualisation, variables, que peut manifester le marqueur.
Aucun(e)(s)/D'aucun(e)(s)/les aucun(e)(s) : évolution du français médiéval au français moderne
Authors: Prévost Sophie , Schnedecker Catherine
Published: May 2023

L’objectif de cet article est de retracer l’ évolution des formes en / aucun / du français médiéval au français moderne. On observe en particulier leur morphologie (répartition féminin/masculin ; singulier, pluriel), leur syntaxe (répartition entre déterminants vs pronoms ; types de morphèmes précédant / aucun /, les fonctions grammaticales) et leur comportement sémantico-référentiel (la restriction des emplois en contexte négatif et l’expression de la partition).
La formation d’un tout : à entre deux noms
Authors: Schapira Charlotte
Published: May 2023

The present study is devoted to the syntactic structure N1 à N2, in which the preposition à is synonymous with avec. We re-examine the various formal and semantic aspects of this structure (N2 with and without an article ; typical feature vs. individual occurrence ; free syntax vs. idiom, etc.) and try to prove that the complement à N2 implies the existence of a paradigm of N1 where each term, conceived as a whole, is formed by the embedment, in the widest possible sense, of N2 in N1, independently of the initial semantic relation between the two nouns.
La «locution» adverbiale pas mal : entre quantité et qualité
Authors: Bacha Jacqueline
Published: May 2023

La locution pas mal, considérée comme familière, est répertoriée par les dictionnaires et les grammaires dans le paradigme des adverbes de manière et/ou de degré. Afin de cerner son identité, nous procéderons dans un premier temps à l’étude de son fonctionnement syntaxique qui nous permettra de situer pas mal par rapport aux autres adverbes exprimant la quantité ou la qualité, notamment beaucoup et bien. Dans un deuxième temps, l’examen de la corrélation entre la locution et l’aspect verbal nous permettra de voir dans quelles conditions pas mal peut recevoir une interprétation soit quantitative, soit qualitative, soit les deux et de constater quelle n’active pas la même quantité selon le verbe auquel on a affaire.
Les noms collectifs : entre quantification et qualification
Authors: Lammert Marie
Published: May 2023

Le but de ce travail est de montrer comment quantification et qualification sont liées dans la catégorie des noms collectifs. Dans une première partie, les noms collectifs sont caractérisés de manière générale. Ensuite, nous rappelons différents comportements distributifs des noms collectifs qui révèlent leur quantité. C’est cette sorte de quantification, associée à certaines formes de qualification, qui conduit au «singulier collectif». Différents types de qualification peuvent ainsi être utilisés pour amorcer une classification sémantique des noms collectifs.
À propos de certains emplois de certainSG antéposé au N : approche historique et synchronique
Authors: Schnedecker Catherine
Published: May 2023

In this contribution, we show that the value and the distribution of certain in SN of the singular are very strongly conditioned by the category of its N adjacent. In particular, with N countable, it marks the specificity of its SN-host whom it lightens considerable indefiniteness. Moreover, SN with certain present the referent as completely new from the point of view of the interpreter but attached to “the experiencial sphere of the speaker” whose knowledge of the referent exceeds that that the lexicon delivers strictly.
Linguistic typology, text structure and appositions
Authors: Korzen Iørn
Published: May 2023

This paper investigates the use and function of the apposition. On the basis of a general distinction between “indicative” constituents (subjects, objects and complements of prepositions, whose text pragmatic function is to indicate - introduce or reiterate - text referents) and “predicative” constituents (predicatives and attributives, which describe - ascribe properties to - referents designated by indicative constituents), it is argued that the apposition belongs to the latter group. It can therefore never be referential or co-referential. The paper also examines the frequency of all the apposition types encountered in a corpus of written and oral Italian and Danish texts. The distribution found confirms the general predominance of nominalising structures in Romance over Germanic languages, and in written over oral texts.
Sur les approches intuitives de la relation d’élaboration
Authors: Kleiber Georges , Vassiliadou Hélène
Published: May 2023

The present article undertakes a reflection on one of the most important discourse relations named Elaboration. The Elaboration relation holds between two sentences in which the eventualities described are in fact the same. Our study invites mostly reflections on the ways in which intuitive definitions on the one hand and the RST theory on the other conceive elaboration. To what extent the current conceptions of this relation influence the analysis of different examples ? It should, finally, be stressed that we are presenting methodological and preliminary suggestions rather than definite results. Our ultimate aim is to compare, in a futur work, these results with some formal definitions in order to draw the bordeline between Elaboration and other discourse relations.
Modalité et place de la négation
Authors: Gosselin Laurent
Published: May 2023

When modality is accompanied with negation, in French as in many other languages, it seems not possible to predict for a given form what will be its meaning because there is a lack of one-to-one correlation between form and meaning (tu ne dois pas sortir ≈ tu dois ne pas sortir ; tu ne peux pas sortir ≈ tu peux ne pas sortir). This paper offers a new hypothesis in order to solve this classical problem. It shows that there is no irregularity at all, but a simple equivalence between contrary negation and contradictory negation, with a class of modal verbs and modal expressions which present other semantic particularities (specifically with regard to interrogation).
Retour sur les prépositions ensemblistes à interprétation spatiale
Authors: Hilgert Dascalu Emilia
Published: May 2023

The purpose of this paper is to prove that set prepositions (entre /d'entre /parmi les N) function in a spatial way. The recognition of this property is supported by syntactic tests which distinguish between typically spatial roles and an 'environment' or 'medium' role. The particular configuration of a set of concrete elements seen as a spatial site requires certain descriptive criteria, specific to sets. This leads to the idea that the three set prepositions form a microsystem, structured around the preposition entre in order to express specific locations.
La relation verticale et ses marqueurs en coréen
Authors: Yun Hee-Seon
Published: May 2023

Notre étude a pour objectif de présenter les marqueurs coréens de la relation verticale dans le cadre d'une étude contrastive. Elle a été motivée par le fait que la notion de verticalité ne résout pas suffisamment le problème de la traduction interlinguistique. Selon les dictionnaires bilingues, il existe une équivalence sémantique entre sur/sous et leurs homologues coréens «(wi/ARAE/MiT)-e». Mais cette équivalence sémantique n'est pas systématique. Nous tâcherons de dresser un aperçu comparatif de ces marqueurs en mettant l'accent sur leurs différences lexico-syntaxiques et sémantiques autour de la notion de verticalité.
Les normes en traduction contre les normes en langue : le cas du slovène
Authors: Schlamberger Brezar Mojca
Published: May 2023

Slovene has been increasing its importance after the inclusion among the European Union languages in 2004. Slovene language has been, as well as Slovene culture, one of major attributes of the Slovene nation before its independence in 1991. The language norm has represented a barrier against more powerful languages within the same state, German and Serbo-Croatian. It is also a language that grew through translations. The translation norm can exist independently of the language norm. We present a brief overview of translation of political and legal texts with regards to the changes in normativity that occurred from the beginning of translating for the European Union at the adhesion period at its end in 2004 when Slovenia joined the EU as well as nowadays. Our research consists on a document and intern translation norms analysis.
Trois questions relatives aux noms généraux factuels attitudinaux
Authors: Adler Silvia
Published: May 2023

Following Schmid's typology (2000), the present study inquires into factual general nouns incorporating the speaker's attitude towards certain states of affaires, in particular into two subclasses of attitudinal nouns : that of Irony (paradox , absurdity, coincidence) and that of Tragedy (catastrophe, drama, disaster). Its major goal consists in motivating the non-specificity of these nouns within context. With this intention, will be reopened the file 'reference and cohesion' - central to the domain of general nouns. Two other objectives consist in (a) distinguishing attitudinal general nouns from general nouns par excellence, on the basis of a criterion other than the frequency of occurrence ; (b) separating general nouns from superordinate nouns.
Typologie des noms : le critère se trouver + SP locatif
Authors: Kleiber Georges , Benninger Céline , Biermann Fischer Michèle , Gerhard-Krait Francine , Lammert Marie , Theissen Anne , Vassiliadou Hélène
Published: May 2023

The aim of this article is to show that we can obtain interesting results in the domain of nominal classification even if we use only one criterion, in our case the spatial structure of localisation se trouver + SP locatif. Our study applies this test to all types of nouns (see, inter alia, mass, countable, abstract, concrete, property, perception nouns) in order to examine which are the best candidates that can be hosted by our target structure. The reader will find a fine description of every possibility or impossibility of use throughout eight "nominal sections" and an explanation for the different reasons of blocking is given in the conclusion. This "experience" may seem limited but it finally turns out to offer very useful information not only about nouns' semantics, but also about space semantics and the construction se trouver + SP locatif itself.
Compléments de manière ou attributs ? Les Sprép après partir
Authors: Lauwers Peter
Published: May 2023

Cette contribution se propose d'explorer la frontière entre l'attribut du sujet accessoire (p.ex. partir joyeux) et le complément adverbial de manière (accessoire) (p.ex. partir joyeusement) dans le domaine des syntagmes prépositionnels (Sprép) : partir en silence vs partir en colère. Sur la base d'une batterie de tests distributionnels, nous montrerons que les Sprép se situent sur un continuum qui s'étend entre deux pôles, un pôle [+ adverbial] et un pôle [+ attributif], et que certains Sprép acceptent les deux analyses. Cette situation rappelle celle des adjectifs-adverbes de manière dans des langues telles que l'allemand et le néerlandais qui ne différencient pas formellement les deux catégories. Si l'étude se limite aux Sprép en sans et en après le verbe partir, elle cherche à replacer la problématique dans un cadre typologique plus large.
Non-full house membranous lupus nephritis represents a clinically distinct subset
Authors: Ye Julia , Croom Nicole , Troxell Megan L. , Kambham Neeraja , Zuckerman Jonathan E. , Andeen Nicole , Dall’Era Maria , Hsu Raymond , Walavalkar Vighnesh , Laszik Zoltan G. , Urisman Anatoly
Published: May 2023

Background:

Renal involvement in systemic lupus erythematosus (SLE) is a key predictor of morbidity and mortality. Immunofluorescence (IF) staining of glomeruli is typically positive for IgG, IgA, IgM, C3, and C1q – the “full house” (FH) pattern. However, a subset of patients with membranous lupus nephritis (MLN) have a “non-full house” (NFH) IF pattern more typical of idiopathic membranous nephropathy (IMN).

Methods:

From a multi-institutional cohort of 113 MLN cases, we identified 29 NFH MLN biopsies. NFH MLN was defined by IF criteria: ≥1+ glomerular capillary loop IgG staining; and <1+ IgA, IgM, and C1q. FH MLN was defined as ≥1+ staining for all five antibodies. “Intermediate” (Int) cases did not meet criteria for FH or NFH. We compared the pathological and clinical characteristics and outcomes among patients with FH, NFH, and Int IF patterns on kidney biopsy.

Results:

NFH MLN represents a subset of MLN biopsies (13.4%). Compared to FH MLN patients, NFH MLN patients were older at SLE diagnosis (29 vs. 22.5 years), had a longer time to initial kidney biopsy (8 vs. 3.16 years), and had fewer SLE manifestations (2.5 vs. 3.36 involved systems). NFH MLN biopsies showed lower C3 IF intensity (1.16+ vs. 2.38+). Int biopsies had findings intermediate between those of NFH and FH groups.

Conclusions:

NFH IF pattern defines a small subset of MLN biopsies and appears to be associated with milder clinical manifestations and slower disease progression. Less robust C3 deposition in NFH MLN may suggest a pathophysiology distinct from that of FH MLN.
The Benefits of Uncertainty and Risk Assessment Studies on the M5 Metro Line (Istanbul - Turkey)
Authors: ÖZÇELİK Mehmet
Published: May 2023

Uncertainty is often the most significant source of risk associated with a project in tunnel and underground construction. Unforeseen uncertainties can lead to significant construction problems leading to reduced tunnel advances and delays, cost increases, damage to existing infrastructure and/or damage to building equipment. The M5 metro line, which is the subject of the study, is located in Uskudar – Umraniye - Cekmekoy - Sancaktepe district on the Asian side of Istanbul. The line is approximately 17.5 km long and has 16 cut and cover stations. M5 metro line was used the four earth pressure balance (EPB) tunnel boring machines. The effect of uncertainty on risk assessment and decision-making is increasingly given priority, particularly for large infrastructure projects such as tunnels where uncertainty is often the primary source of risk. This article is intended to explain the tangible benefits of underground uncertainty and risk assessment of the M5 metro construction for underground project stakeholders, local authorities, designers, practitioners and researchers.
Chemical Characterization of Ultra High Molecular Weight Polyethylene Based Tibial Inserts After Ethylene Oxide Sterilization
Authors: BOZKAYA Ogün
Published: May 2023

Ultra-high molecular weight polyethylene (UHMWPE) has become the gold standard for total joint replacements such as tibial inserts because of its chemical inertness, superior mechanical properties, and biocompatibility. Ethylene oxide sterilization is one of the most common and effective methods used, especially for the sterilization of polyethylene-based polymeric implants. However, variable sterilization conditions can cause a change in the chemical structure of the polymeric material, which affects its mechanical properties and lifetime. The aim of this study is to investigate whether the chemical structure of UHMWPE tibial inserts sterilized with ethylene oxide undergoing certain conditions remains the same. Chemical characterization studies were performed with Fourier transform infrared spectroscopy, Raman spectroscopy, X-ray diffractometer, differential scanning calorimetry, thermogravimetric analysis, mass spectrometry and elemental analysis techniques recommended for polymeric materials in ISO 10993-8:2020 standard. According to the FTIR results, the spectra of the non-sterile and sterile tibial inserts were compared, and it was determined that the similarity between them was 99.97%. XRD results revealed that after ethylene oxide sterilization, there was no significant shift in the Bragg (1 0 0) peak. The percentages of crystallinity calculated from the fusion enthalpies determined by DSC of sterile and non-sterile samples are 54.3% and 53.3%, respectively. Characterization results revealed that there was no significant change in molecular structure, crystallinity, elemental composition of UHMWPE materials after ethylene oxide sterilization. These results can provide assurance that tibial inserts keep their physical, chemical, and mechanical properties after sterilization.
Compiler Technologies in Deep Learning Co-Design: A Survey
Authors: Zhang Hongbin , Xing Mingjie , Wu Yanjun , Zhao Chen
Published: May 2023

With the rapid development of deep learning applications, general-purpose processors no longer suffice for deep learning workloads because of the dying of Moore’s Law. Thus, computer architecture innovation has entered a golden age for domain-specific design, which has led to a demand for new compilation technologies to facilitate cross-layer optimization. Historically, hardware and software have been collaboratively designed. Today, these co-design ideas still benefit the deep learning field in both academia and industry, encompassing additional aspects and layers. In this study, we elaborate on past and recent works on deep learning compilers and co-design while focusing on the combination of these two technologies, which we believe is the trend in the new deep learning era. After summarizing the existing compilation technologies and co-design approaches, we propose a domain-specific compilation framework, the Buddy Compiler, for a typical deep learning co-design system.
Etika Bisnis Pada Usaha Kecil dan Menengah dengan Pemanfaatan Instagram dan Komunikasi Media Komputer
Authors: Kho Ardi , Jayanegara Oscar , Aristo Benny , Surya Wuisan Dewi Sri
Published: May 2023

Perkembangan teknologi dalam komunikasi yang terjadi melalui media sosial atau lingkungan virtual. Komunikasi media sosial disebut sebagai komunikasi yang dimediasi komputer. Situs web media sosial seperti Facebook, Instagram, dan lainnya disebut sebagai CMC. Jarak dan waktu bukanlah penghalang untuk berkomunikasi saat menggunakan media sosial. masyarakat di media sosial juga memanfaatkan aktivitas jual beli yang dilakukan oleh sebagian orang. Banyak pengguna menggunakan program media, khususnya Instagram saat menggunakan media sosial untuk aktivitas jual beli. Salah satu sarana online yang digunakan untuk berbisnis di media sosial adalah Instagram. Vendor yang menjalankan bisnis dengan menggunakan platform online seperti Instagram diharapkan beretika dalam mendorong pengguna aplikasi. Kegiatan bisnis media sosial membutuhkan etika. Etika bisnis adalah penerapan konsep etika bisnis untuk meneliti dan mengatasi masalah moral yang sulit. Etika bisnis adalah pelaksanaan aktivitas bisnis di media sosial untuk memastikan persaingan yang sehat antar bisnis.
Fixings that Ensure the Free Movement of the Structure for Resistance in Relation to Non-Structural Walls
Authors: IERNUTAN Răzvan Andrei , PLEȘA Luminița Monica
Published: May 2023

Recent earthquakes have confirmed that non-structural walls interacting mainly with frame structures are severely damaged during seismic actions endangering human lives. The ongoing life after earthquakes and major costs for rebuilding are deeply affected. In order to avoid this kind of drawbacks, the present paper suggests the introduction of a set of joints between the structure and the nonstructural closing and division walls. The joints should observe the following: joints will be designed to provide free development of displacements in the plane of the walls with no major interactions in the structure; joints will be designed to provide transmission of the seismic forces acting perpendicularly to the non-structural walls towards the main structure. This paper will include several conclusions concerning the admission, constraint or removal of interactions between the structure and the closing and division walls.
Importance of Simulating the Steel Flow Process in the Tundish, on the Quality of Continuously Cast Slabs
Authors: TUDOR Beatrice Daniela , MATROOD Ali Jawad Jaber
Published: May 2023

The benefits of using mathematical modeling of the flow are obvious, the final objective being the elimination of as many inclusions as possible during the flow of steel through the tundish, and thus, obtaining steel with superior quality.In this work, a simulation of the movement of the liquid alloy in the tundish was carried out, in order to highlight the erosion of its refractory lining. For this, we used SolidWorks, RealFlow, and ABAQUS programs.Using these simulation programs, the filling method of the tundish, the contact area of the alloy jet with the tundish wall, and the "dead" areas are highlighted, as well as the turbulences that can appear during the flow, which have a negative impact on the quality of the steel.
The Effect of Maltodextrin Concentration and Spray Dryer Drying Temperature on the Characteristics of Coconut Milk Powder
Authors: Yulistiani Fitria , Nuraeni Alifia , Sheilla Aulia Sofiatul Mardiah  , Hidayatulloh Irwan , Elizabeth Lidya , Nurcahyo
Published: May 2023

Coconut milk has a higher water content than other contents, so microbes can easily damage and spoil it. To obtain a low-moisture powder product, the liquid coconut milk was dried using a Buchi Mini Spray dryer B-290 with inlet temperatures of 150°C, 160°C, and 170°C. The researchers added maltodextrin to coconut milk, which had a ratio of grated coconut to the water of 1:3, in concentrations of 9%, 10%, 11%, 12%, and 13%. The addition of maltodextrin and the use of drying temperature did not significantly affect the pH, solubility, and percentage of product mass but did significantly affect the moisture content. The best operating conditions for producing coconut milk powder were at a maltodextrin concentration of 13% and a temperature of 170°C. Under these conditions, the produced coconut milk powder had a pH value of 6.12, a moisture content of 4.56%, a solubility of 98.74%, a product mass of 24.99 grams and an overall percentage of product mass of 21.32%.
Hydrolysis of Waste Cooking Oil Using Rhizopus oryzae to Produce Free Fatty Acids
Authors: Manfaati Rintis , Connery Manurung Prans , Muhamad Nur Rojab  , Keryanti Keryanti
Published: May 2023

Waste cooking oil is waste produced from palm oil after it has been heated and fried at high temperatures, and it can pollute the environment. One effort to reuse waste cooking oil is a fermentation processe that produces free fatty acids with the help of Rhizopus oryzae as a biocatalyst. Variations in initial substrate concentration ranged from 10 g/L to 70 g/L, followed by varied types of nitrogen sources, namely malt extract, beef extract, (NH2)2CO, NH4Cl, and (NH4)2SO4 at a concentration of 70 g/L to determine free fatty acid concentration. Fermentation was carried out for 7 days. The analysis carried out included the concentration of free fatty acids, biomass, and YP/X value. The optimum initial used cooking oil substrate was obtained at a concentration of 30 g/L with a YP/X value of 13.63%, a free fatty acid concentration of 2.13 g/L and a dry cell weight of 15.48 g/L. The best nitrogen source is beef extract with a Yp/x value of 11.78%, a free fatty acid concentration of 2.02 g/L and a dry cell weight of 17.0 g/L