bluuebunny/crossref_metadata_2025 huggingface dataset:
Więź z miejscem. Wokół pracy z utworami Doroty Terakowskiej w szkole podstawowej
Authors:   Uniwersytet Pedagogiczny w Krakowie, Pławecka Katarzyna Maria
Published: April 2022

Bond with the place. On Dorota Terakowska’s works in primary school The article on arousing the love of reading and of place from the perspective of modern Polish educational practice (using as an example works by Dorota Terakowska) is a contribution to the broad problem of teaching literature and language in the contemporary school. Special consideration is given to arousing in young people a love of reading set texts and of their home region. A proposal for a literary tour around Krakow that allows students at elementary school to travel to two different (and thus not dull) worlds is included in the framework of a specially designed project involving: 1. real places, close to their life experience, and 2. parallel places, recorded in the literature of D. Terakowska, i.e., Grandma Brygida’s crazy journey around Krakow [Babci Brygidy szalona podróż po Krakowie], The Lord of the Lewaw [Władca Lewawu]. The proposed activities, as it turned out in practice, were an effective way of encouraging students to read and “put down roots in the soul.”
Etyczny wymiar niepełnosprawności w wybranych powieściach Doroty Terakowskiej
Authors:   Uniwersytet Jagielloński, Fidowicz Alicja
Published: April 2022

The ethical aspect of disability in chosen novels of Dorota Terakowska The aim of this article is to set out the ethical aspect of disability present in two novels by Dorota Terakowska: Where the angels fall down [Tam, gdzie spadają anioły] and Pupa [Poczwarka]. The philosophy of Simo Vehmas, an author based in Stockholm, is the starting point to ask about ethical issues connected with disability. Vehmas noted three definitions of this phenomenon: universalist, subjectivist, and communitarian. Reading Terakowska’s prose makes it possible to observe two representations of disability in Polish culture (traditional, based on Christianity, the ideology of the Romanticism, and Slavic folk culture, and contemporary, based on the development of medicine and the idea of the welfare state in the second half of the 20th century). Ethical ideas proposed by Terakowska are an interesting alternative to existing views because there is an evident perspective of a person with a disability.
s-Compressible and s-Prime Modules
Authors: Alhossaini Asaad M. A.
Published: April 2022

Let R be a ring with identity and Ą a left R-module. In this article, we introduce new generalizations of compressible and prime modules, namely s-compressible module and s-prime module. An R-module A is s-compressible if for any nonzero submodule B of A there exists a small f in HomR(A, B). An R-module A is s-prime if for any submodule B of A, annR (B) A is small in A. These concepts and related concepts are studied in as well as  many results consist properties and characterizations are obtained.
Crawling and Mining the Dark Web: A Survey on Existing and New Approaches
Authors: Alshammery Mohammed Khalafallah , Aljuboori Abbas Fadhil
Published: April 2022

The last two decades have seen a marked increase in the illegal activities on the Dark Web. Prompt evolvement and use of sophisticated protocols make it difficult for security agencies to identify and investigate these activities by conventional methods. Moreover, tracing criminals and terrorists poses a great challenge keeping in mind that cybercrimes are no less serious than real life crimes. At the same time, computer security societies and law enforcement pay a great deal of attention on detecting and monitoring illegal sites on the Dark Web. Retrieval of relevant information is not an easy task because of vastness and ever-changing nature of the Dark Web; as a result, web crawlers play a vital role in achieving this task. Thereafter, data mining techniques are applied to extract useful patterns that would help security agencies to limit and get rid of cybercrimes. The aim of this paper is to present a survey for those researchers who are interested in this topic. We started by discussing the internet layers and the properties of the Deep Web, followed by explaining the technical characters of The Onion Routing (TOR) network, and finally describing the approaches of accessing, extracting and processing Dark Web data. Understanding the Dark Web, its properties and its threats is vital for internet servers; we do hope this paper be of help in that goal.
Comparación de la satisfación de futuros maestros/as en las modalidades formativas en línea y mixta a través del programa web Trazo
Authors:   Universidad de La Laguna (España), Seoane Rocío C. , Jiménez Juan E. ,   Universidad de La Laguna (España)
Published: April 2022

El presente estudio persigue conocer si la satisfacción con un programa de formación web para la enseñanza de la escritura (programa web Trazo) depende de si la formación se ofrece en las modalidades en línea y mixta. Se confrontan dos grupos de maestros/as en formación que cursaron el programa web Trazo bajo dos modalidades formativas (en línea, n=70 y grupo mixto n= 88). Los resultados demuestran que el grupo en línea ofreció una valoración significativamente mayor de la formación recibida que el grupo mixto en cuatro de las dimensiones evaluadas. No se encontraron diferencias estadísticamente significativas entre grupos en la valoración atribuida al rol de las interacciones en el espacio web. Finalmente, se discuten las implicaciones educativas de evaluar la satisfacción de los futuros maestros/ as tras experiencias formativas en línea.
Responsabilidad social a través del trabajo colaborativo: herramientas virtuales y recursos didácticos en inglés
Authors:   Universidad de Málaga, Díaz Muñoz Rocío , Quintana García Cristina ,   Universidad de Málaga, Marchante Lara Macarena ,   Universidad de Málaga, Martín Machuca Marta ,   Universidad de Málaga
Published: April 2022

El presente trabajo muestra los resultados obtenidos en un proyecto de innovación docente orientado al diseño de instrumentos pedagógicos para el desarrollo de dos competencias transversales, en el marco del Espacio Europeo de Educación Superior (EEES): la respon-sabilidad social corporativa (RSC) y el aprendizaje del inglés. Se introdujeron aspectos formativos sobre RSC en veinticinco asignaturas de quince titulaciones diferentes. Se dise-ñaron estrategias didácticas de naturaleza participativa y flexible, mediante la utilización del aprendizaje basado en problemas (ABP), en lengua extranjera (inglés). El empleo de las aulas virtuales y las herramientas del campus virtual («wikis» y foros) facilita al alumnado un entorno de aprendizaje diverso, con participación intensa y selectiva en la ejecución de las actividades programadas y en su particular proceso de aprendizaje.
Flipped Classroom: una experiencia con estudiantes universitarios
Authors:   Universidad de Málaga, Díaz Muñoz Rocío , Estévez Rojas Sergio
Published: April 2022

Este trabajo desarrolla una experiencia basada en el sistema Flipped Classroom con 110 estudiantes de grado universitario. Se han recogido sus opiniones, percepciones y valoración sobre su satisfacción con este método, en comparación con el sistema tradicional. La idea central es contribuir a conocer cuáles son los resultados de la aplicación de un modelo de Aula Invertida en algunas asignaturas universitarias, de forma que se puedan recoger datos sobre las percepciones y opiniones de los principales protagonistas del aprendizaje: el alum-nado. Esto se encuadra bajo un marco de mejora continua que permita a los estudiantes valorar una propuesta de AI respecto de lo que hasta ahora conocen y se puede denominar como enseñanza tradicional.
Notas sobre la autoficción en la obra de María Velasco
Authors:   Universidad de La Laguna (España), Pérez Cabrera Felipe Santiago
Published: April 2022

Current dramaturgy claims gender studies as a primary critical field and María Velasco develops a significant dramatic production capable of being analyzed. Metafiction as a phenomenon that introduces the autofictional fact is based on the idea of theatre within theatre on the basis of two facts: the first consists of entering the intricacies of the theatrical structure and the second establishes collecting fragments of reality to materialize them in the scene. Autofiction is a phenomenological resource that acquires relevance in Velasco’s work: it is a formula that consists of approaching the aspect from a fictional perspective, providing a significant number of literary resources in the texts presented by the author. The autobiographical is established to include personal aspects that acquire added value; the result is the symbiosis between fiction and reality. The aim she pursues corresponds to the catharsis that occurs in the development of her performance.
Cartografías del cuerpo femenino en el teatro de títeres de Winged Cranes
Authors:   Universidad Rey Juan Carlos (España9, Prieto García Alejandra
Published: April 2022

This research focuses on the different visions of the female body and the gender issue in puppet theatre in Spain developed by the theatre company Winged Cranes based in Madrid through the study of three of its most relevant productions: Don Kiss me, I’m in training; The soldier with no name and Bernarda’s Backstage. An analysis of the multicultural and interdisciplinary contexts in which Winged Cranes has been formed and developed its artistic work is proposed. The performative bodies created by this company for the stage are analyzed by examining the puppets shown in its productions. This investigation values the contribution of Winged Cranes to the representation of women in puppet theatre and theatre in general in Spain from a feminist and a gender perspective.
«Soy un museo de máscaras infinitas»: autoficción e identidad en Lacura (2016) y Pogüerful (2019), de Bibiana Monje
Authors: Alayón Galindo Carlos
Published: April 2022

Bibiana Monje (Tenerife, 1983) and her literary works will be the objects of study in this paper. She will be analyzed from the concept of ‘autofiction’ in this research, it will be applied for drama due to the theoretical proposals put forward by authors like Ana Casas or García Barrientos. From such a theoretical framework, it will be first dealt with how Bibiana Monje’s voice approaches autofiction and, to a certain extent, modernizes it, together with the implications of said approach. Special attention will be paid to the multiple selfs that appear in the scene as to the use of metaficcitional resources. Second, the interest is centered in establishing the elements and mechanisms employed in the characterization of such a voice, written from an insular and female autoconscience.
«Para agarrarse a la tierra»: memoria e identidad en Nome: Bonita (2014), de Vanesa Sotelo
Authors:   Universidad Complutense de Madrid (España), Hernández Martín Joel
Published: April 2022

Galician actress, playwright and theater director Vanesa Sotelo (1981) carries out, through her dramatic writing, a poetic search for identity in her female characters. In texts like Nome: Bonita (2014) the same concern always beats: the scope of knowledge through the discovery of roots, the encounter with the ancestors or the understanding of deeply personal and identity issues. Along with this theater of identity, Sotelo develops a theater of memory, by recovering historical female figures from the Galician social and historical context. In this sense, its main characters are great female figures forgotten by history who carry out their own inquiry as an act of vindication. They seek their identity and, at the same time, their deserved place in the collective memory. This article will try to explore the discursive and thought keys of these concerns of the playwright and, at the same time, it will propose to analyze what are the dramaturgical tools that she uses to address them in her dramatic text Nome: Bonita. In short, this research aims to highlight the figure of a playwright who does not hesitate to use her theater to value other great women of her cultural heritage.
Thermal loading of spent rocket stage structure during ballistic descent
Authors:   Omsk State Technical University, Kudentsov V. Yu. , Kudentsov A. V. ,   Omsk State Technical University, Kuzina N. A. ,   Omsk State Technical University, Bimatov V. I. ,   Tomsk State University
Published: April 2022

The results of a numerical calculation of the aerodynamic heating of a spent rocket stage structural elements during its controlled descent along a ballistic trajectory are presented. The influence of the initial trajectory parameters on the specific convective and radiant heat fluxes is determined. To assess the thermal loading of the spent rocket stage structure, the parameter of the total specific energy flux is introduced. It has been established that in the range of initial speeds of the spent rocket stage from 1800 m/s to 2600 m/s, an increase in the initial speed by 200 m/s leads to an increase in the specific convective flow by an average of 11 % for the tail compartment and the fuel tank and by 5 % for the oxidizer tank. The share of the specific radiant energy flux withdrawn from the surface in relation to the specific convective energy flux is from 0,15 to 0,19 for the tail compartment, from 0,12 to 0,15 for the fuel tank and not more than 0,009 for the oxidizer tank. Empirical dependencies are proposed for the preliminary stage of assessing the temperature state of the spent rocket stage structure when moving on a ballistic trajectory. The error of the calculation results according to the proposed dependencies does not exceed 12 %.
Calorimetric studies of microwave ion thruster
Authors:   Omsk State Technical University, Vavilov I. S. , Zharikov K. I. ,   Omsk State Technical University, Yachmenev P. S. ,   Omsk State Technical University, Fedyanin V. V. ,   Omsk State Technical University, Stepen P. V. ,   Omsk State Technical University, Lukyanchuk A. I. ,   Omsk State Technical University, Kuzmenko I. A. ,   Omsk State Technical University
Published: April 2022

The authors continue their work in the field of calorimetric studies of the parameters of an accelerated ionized gas jet of prototypes of microwave ion micro-thrusters with an energy consumption of up to 10 watts. This paper presents an improved calorimetric method. The introduction into the design of a heat receiver in the form of a thin screen makes it possible to allocate the thermal component formed by the passage of an electric current through the plasma in the accelerating gap. Calorimetric studies of the prototype with a two-electrode accelerating system are carried out at the same accelerating voltages and power of the microwave generator and different mass gas flow rates. It is shown that at a nitrogen consumption of 5,668•10–9 kg/s, the velocity of the mixed jet (neutral gas with ionized component) of the gas was 63,75 m/s, the jet thrust is 0,36 μN. With a nitrogen consumption of 1,611•10–8 kg/s, the speed of the mixed gas jet was 47,9 m/s, the jet thrust was 0,77 μN.
Intensification of convective heat exchange of walls of heat pipe of 3D-printed micro-sized turbojet engine
Authors:   Baltic State Technical University «VOENMEH» named after D. F. Ustinov, Pobelyansky A. V. , Dmitriev D. K. ,   Baltic State Technical University «VOENMEH» named after D. F. Ustinov, Levikhin A. A. ,   Baltic State Technical University «VOENMEH» named after D. F. Ustinov
Published: April 2022

The article considers the solution of the urgent problem of creating a micro-sized turbojet engine using 3D printing. The article describes one of the ways to cool the walls of the heat pipe of a small combustion chamber made of heat-resistant material 08KhN53BMTYu. One of the acceptable ways to cool the walls of a small-sized chamber heat pipe is convective heat exchange of the outer side of the heat pipe due to intense vortex formation in the boundary layer of the flow. This effect is achieved by the device of projections on the outer wall of the heat pipe. The article highlights the peculiarity of the shape of the protrusions, which must be carried out taking into account the technological limitations of 3D printing. The article presents a description of an experimental stand for the study of the thermal state of the heat pipe of micro turbojet engines, the method of processing experimental data and the results of experiments on the heat transfer of the heat pipe shell with and without them.
The analysis of influence of uncertainty factors on mathematical modeling of process of reverse expansion of ammonia in low-speed reciprocating compressor stage. Part 1
Authors:   Omsk State Technical University, Sadvakasov D. Kh. , Chernov G. I. ,   Omsk State Technical University, Yusha V. L. ,   Omsk State Technical University
Published: April 2022

The paper presents an analysis of the influence on the mathematical modeling of the process of reverse expansion of ammonia in the area of wet steam, implemented in the working chamber of the reciprocating compressor stage, of such uncertainty factors as the method for calculating the heat transfer coefficient, the surface temperature of the wall of the working chamber and the degree of dryness at the beginning of the process of reverse expansion. The mathematical model is based on the equations of the first law of thermodynamics for a body of variable mass, the equation of state of a real gas, the Clausius– Clausius and Newton–Richmann equations. The results of the calculation showed that the instantaneous values of the pressure and temperature of ammonia, as well as its degree of dryness during reverse expansion in the wet steam region, significantly depend on the chosen method for calculating the heat transfer coefficient. The process under consideration is also significantly influenced by the temperature of the walls of the compressor working chamber, in which the compression process is implemented, and the degree of dryness of ammonia at the beginning of the expansion process.
Numerical study of pipeline wall thickness influence on natural dynamic parameters of hydromechanical system
Authors:   Ural Federal University named after the first President of Russia B. N. Yeltsin, Sekacheva А. А. , Pastukhova L. G. ,   Ural Federal University named after the first President of Russia B. N. Yeltsin, Noskov А. S. ,   Ural Federal University named after the first President of Russia B. N. Yeltsin
Published: April 2022

This article is devoted to solving the problem of noise and vibration in complex pipelines of hydromechanical systems. In the study, the first ten frequencies of natural oscillations are calculated for sections of the pipeline system filled with water with outer diameters of 60, 70, 102 mm and various thicknesses of the pipeline wall. It is determined that for all the investigated diameters, a decrease in the natural vibration frequencies for all modes of natural vibrations with an increase in the thickness of the pipeline wall is characteristic. Thus, the assumption is confirmed that an increase in the rigidity of the pipeline reduces the likelihood of oscillations in the pipeline. It is concluded that in straight sections the pipeline system with diameters up to 102 mm behaves only as a mechanical system.
M. Fouladivanda, M. A. Heidary. A study into the impact of chloride ions on the make-up hydrogen compressors / trans. from Engl. M. A. Fedorova
Authors:   Omsk State Technical University, Fedorova M. A.
Published: April 2022

The presence of unwanted chemicals in process lines and downstream equipment causes defects and failures, which sometimes have significant impacts on systems and imposes extra costs for the production process. In this study, one pair of four-stage make-up hydrogen compressors is investigated. These reciprocating compressors which serve as a part of the hydrogen treating unit have failed approximately simultaneously. The feed of these compressors is net hydrogen-rich gas. Both dry compressors have shown similar problems in the first and second stages. The simultaneous rise in the cylinder temperature and decrease in the flow has forced shut-down of the compressors for the next actions in the process. Initial inspections have revealed some kind of deposits covered the cylinder and its components. The valves, liquid tested and results have shown significant leakage of all the suction and discharge valves of the cylinders. Moreover, the thickness of all piston rings have decreased up to 50 percent which is more than allowable values. The compositions of deposits, tested by X-ray fluorescence (XRF) and X-ray diffraction (XRD), result from the analysis shown that it contains 35,2 percent (mass fractions) of Chlorine and 27,5 percent of Iron, and noticeable amount of Sulfur or Phosphor. XRD analysis has reported that the Iron Chloride Hydrate is the main part of the fouling sample. In this paper, the impact of the aforementioned chemicals on the compressor components are investigated, and some approaches are proposed to absorb or inhibit these chemicals.
Physical and mathematical model of working process of the Hartmann–Sprenger tube
Authors:   Omsk State Technical University, Kuznetsov V. I. , Makarov V. V. ,   Omsk State Technical University
Published: April 2022

The question of the operation of the Hartmann–Sprenger tube is considered. The influence of the parameters of the incident gas flow on its parameters at the end of the dead-end cavity is investigated. The mechanism of energy transfer from the incoming flow to the flow entering the dead-end cavity has been determined. The proof of the influence of viscosity and shear stresses on the occurrence of transfer of kinetic energy from the incident flow to the flow entering the dead-end cavity is given. The influence of the exchange of work and heat on the mechanism of energy transfer in the dead-end cavity of the Hartmann– Sprenger tube is revealed.
Institutional Design of The Regional House of Representatives (DPRD): Legal Political Study on Indonesia’s Law Number 23 of 2014 concerning Regional Government
Authors: Tauda Gunawan A. , Umasangaji Amirudin , Rumkel Nam , Istiqamallah Nurul
Published: April 2022

By the promulgation of Regional Government Law (no. 23/2014), there has been a shift in the institutional design of the Regional House of Representatives (DPRD in Bahasa Indonesia), especially in the aspects of the legislative function and its authority, and there is an affirmation of the understanding of the DPRD as an element of regional government administration. In this context, the House of Representatives (DPR in Bahasa Indonesia) and the President deliberately combine the two types of power functions, the legislative and the executive, into one institution called the DPRD in the local government system in Indonesia. Shifting of institutional design above indicates that Regional Government Law is principally no longer categorizes the DPRD as a legislative agency, but rather as an executive institution playing a role in supervising the implementation of Regional Government. Based on this Regulation, the theoretical interpretation of DPRD’s existence is interpreted as an executive institution running the legislative function.
PERANAN KONTROL SOSIAL DAN OPTIMALISASI KEBIJAKAN KEADILAN RESTORATIF PADA ANAK PELAKU TINDAK PIDANA
Authors: Pertiwi Yuarini Wahyu , Saimima Ika Dewi Sartika
Published: April 2022

Lembaga Pemasyarakatan Khusus Anak (LPKA) Jawa Barat merilis, tahun 2020 terdapat 241 jumlah tahanan anak dan 429 napi anak. Perilaku pidana pada anak terikat dengan kontrol sosial seperti attachment, responsibility, involvement, dan believe yaitu semakin positif ikatannya semakin rendah kemungkinan terjadi pelanggaran hukum. Isu utama dari penyelesaian perkara pidana anak adalah sistem peradilan pidana yang tidak berpihak terhadap anak karena penanganannya yang belum menerapkan kebijakan keadilan restoratif. Anak yang melakukan tindak pidana idealnya perlu dikembalikan ke kondisi semula, tidak hanya sekedar menghukum perbuatannya. Faktanya, data tahanan anak dan napi anak menunjukkan indikasi kebijakan keadilan restoratif yang kurang optimal. Tujuan penelitian ini untuk mengetahui peran kontrol sosial pada anak sebagai pelaku tindak pidana dan untuk mengetahui kebijakan keadilan restoratif pada proses penyelesaian perkaranya. Penelitian ini adalah deskriptif, teknik analisis data yaitu kualitatif dengan pendekatan yuridis normatif dan yuridis empiris. Subjek penelitian berjumlah 22 napi anak dan tahanan anak di salah satu Lembaga Pemasyarakatan wilayah Jawa Barat. Hasil penelitian menunjukkan kontrol sosial berperan terhadap anak sebagai pelaku tindak pidana, serta penyelesaian perkara pidana anak berdasarkan kebijakan keadilan restorative belum optimal. Banyak kegagalan diversi dan persentase cukup tinggi pada putusan pidana penjara yang seharusnya menjadi pilihan terakhir. Stigma masyarakat juga besar bahwa anak yang melanggar hukum harus dipenjara. Pada sisi lain, trauma proses pemeriksaan, kehidupan penjara, sampai stereotip mantan napi mempengaruhi fungsi psikologis anak, dimana menjadikan kurang percaya diri karena merasa tidak berharga, bahkan menjadi penyebab sebagai residivis karena merasa tidak termaafkan meskipun sudah menjalani hukuman.
Polymorphic microsatellite loci for the primitively eusocial wasp Ropalidia fasciata (Hymenoptera: Vespidae)
Authors:   Laboratory of Insect Ecology, Faculty of Education, Niigata University, Niigata 950- 2181 Japan, Kudô K. , Katada S. ,   Laboratory of Biodiversity, Tokyo Kasei University, Tokyo 173-8602 Japan, Hasegawa E. ,   Laboratory of Animal Ecology, Department of Ecology and Systematics, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589 Japan, Igarashi S. ,   Laboratory of Insect Ecology, Faculty of Education, Niigata University, Niigata 950- 2181 Japan, Sekihara N. ,   Laboratory of Insect Ecology, Faculty of Education, Niigata University, Niigata 950- 2181 Japan, Yamaguchi Y. ,   Laboratory of Insect Ecology, Faculty of Education, Niigata University, Niigata 950- 2181 Japan, Yamahira K. ,   Tropical Biosphere Research Center, University of the Ryukyus, Okinawa Japan, Koji S. ,   Laboratory of Insect Ecology, Graduate School of Science and Technology, Niigata University, Niigata 950-2181, Japan
Published: April 2022

A polymorphic microsatellite locus was isolated and characterized from Ropalidia fasciata (Fabricius, 1804), one of the most common in South-East Asia independent-founding polistine wasps (Vespidae: Polistinae). Four other microsatellite loci for which the primer sets were originally developed in two Ropalidia species also showed polymorphism in the size of amplification products in R. fasciata.
KOAHLI BİREYLERDE SOLUNUM EGZERSİZİ VE İNHALER CİHAZ KULLANIMININ BAZI SEMPTOMLARA VE PSİKOSOSYAL PARAMETRELERE ETKİSİ
Authors: ÖZDEMİR Ayşe , YILDIZ GÜLHAN Pınar , ARABACI Zeynep , HASGÜL Ergün
Published: April 2022

Amaç: Bu çalışma kronik obstrüktif akciğer hastalığı olan bireylerde solunum egzersizleri ve inhaler cihaz kullanımının dispne, yaşam kalitesi, anksiyete, depresyon üzerine olumlu etkisini incelemek amacı ile yapılmıştır. Gereç ve Yöntem: Bu çalışma tek grup, ön test-son test düzeninde, yarı deneysel olarak 30 KOAH tanılı yetişkin hasta ile yapılmıştır. Araştırma verilerinin analizinde SPSS 22 paket programı kullanılmıştır. Verilerin değerlendirilmesinde tanımlayıcı istatistiksel ve parametrik ve non-parametrik testler kullanılmıştır. İstatistiksel anlamlılık için p
Übergangsmetall-Katalysatoren für die Olefinpolymerisation: 2. Herstellung von stereoregularen Poly(1-olefinen)
Authors: Mülhaupt Rolf , Rieger Bernhard
Published: April 2022

The insertion polymerization of propene by using chiral transition metal compounds leads to a variety of poly propene products with different stereoregularities. The classical, heterogeneous Ziegler-Natta catalysts, based on Ti(III) as active species, produce isotactic, highly
crystalline materials with melting points above 160°. These materials find manifold applications, e.g. for packaging as well as in the car industry. Within the last 15 years molecular defined organometallic complexes were developed. These catalysts allow the production of new stereoregular
polyolefins and a precise control of its properties by tailoring the ligand environment.
Single Voxel ¹H-MR Spectroscopy in the Human Spinal Cord at 3T -Preliminary Results
Authors:   Department of Radiology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland, P Wawrzyniak , A Hebda ,   Department of Radiology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland, S Heinze ,   Department of Radiology, Maria Sklodowska-Curie National Research Institute of Oncology, Cracow Branch, Poland, B Bobek-Billewicz ,   Department of Radiology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
Published: April 2022

Purpose: ¹H-Magnetic Resonance Spectroscopy is a non-invasive technique that provides information on tissue metabolism and biochemistry. Because of technical difficulties, this method is rarely used in the spinal cord examination. The main goal of this study was to develop a routine protocol for MRS of intramedullary lesions. Material and methods: ¹H-MRS protocol was set on a group of healthy volunteers. 48 spectra were acquired in total. 30 of them were acquired in cervical spinal cord and the remaining (18 spectra) were acquired in the thoracic spinal cord. Results: In ¹H-MRS of the spinal cord one of the most important problem is small voxel size. Mean voxel size in this study was 7x9x29 mm - what is much smaller than in the brain examinations finally, almost 60% of spectra were of acceptable quality in volunteer examinations, what enabled the following patients’ examinations. Conclusions: Challenges of spinal cord spectroscopy were discussed and the ability of providing additional diagnostic information was proved.
Discovery of an orally bioavailable and selective PKMYT1 inhibitor RP-6306
Authors: Szychowski Janek , Papp Robert , Dietrich Evelyne , Liu Bingcan , Valee Frederic , Leclaire Marie-Eve , Fourtounis Jimmy , Martino Giovanni , Perryman Alexander , Pau Victor , Yin Shou Yun , Mader Pavel , Roulston Anne , Truchon Jean-Francois , Marshall Gary , Diallo Mohamed , Duffy Nicole , Stocco Rino , Godbout Claude , Bonneau-Fortin Alexanne , Kryczka Rosie , Bhaskaran Vivek , Mao Daniel , Beaulieu Patrick , Turcotte Pascal , Orlicky Stephen , Kurinov Igor , Sicheri Frank , Mamane Yael , Gallant Michel , Black Cameron
Published: April 2022

PKMYT1 is an important regulator of CDK1 phosphorylation and is a compelling therapeutic target for the treatment of certain types of DNA damage response cancers due to its established synthetic lethal relationship with CCNE1 amplification. To date, no selective inhibitors have been reported for this kinase that would allow for investigation of the pharmacological role of PKMYT1 in the treatment of cancer. To address this need we conducted a focused screening effort that identified compound 1 as a weak PKMYT1 inhibitor. Introduction of a dimethylphenol dramatically increased potency on PKMYT1. These dimethylphenol analogs were found to exist as Type III atropisomers that could be separated and profiled as single enantiomers. Structure-based drug design aided by co-crystal structures of several analogs enabled optimization of cell-based potency and kinase selectivity. Parallel optimization of ADME properties led to the identification of potent and selective inhibitors of PKMYT1 with favorable pharmacokinetics. RP-6306 inhibits the phosphorylation of CDK1 Thr14 in vivo in tumor tissue and inhibits CCNE1-amplified tumor cell growth in several preclinical xenograft models. The first-in-class clinical candidate RP-6306 is currently being evaluated in Phase 1 clinical trials (NCT04855656) for treatment of various solid tumors.
The onset of CVD graphene formation on γ-Al2O3 is promoted by unsaturated CH2 end
Authors: Zhao Qi , Yamamoto Masanori , Yamazaki Kaoru , Nishihara Hirotomo , Crespo-Otero Rachel , Di Tommaso Devis
Published: April 2022

Chemical vapor deposition of methane onto a template of alumina (Al2O3) nanoparticles is a prominent synthetic strategy of graphene meso-sponge, a new class of nanoporous carbon materials consisting of single-layer graphene walls. However, the elementary steps controlling the early stages of graphene growth on Al2O3 surfaces are still not well understood. In this study, density functional calculations provide insights into the initial stages of graphene growth. We have modelled the mechanism of CH4 dissociation on (111), (110), (100), and (001) γ-Al2O3 surfaces. Subsequently, we have considered the reaction pathway leading to the formation of a C6 ring. We found the γ-Al2O3(110) and γ-Al2O3(100) are both active for CH4 dissociation, but the (100) surface has a higher catalytic activity towards the carbon growth reaction. The overall mechanism involves the formation of the reactive intermediate CH2* that then can couple to form CnH2n* (n = 2-6) species. The unsaturated CH2 end promotes the sustained carbon growth in a nearly barrierless process. Also, the short length between terminal carbon atoms leads to strong interactions, which might lead to the high activity among unsaturated CH2* of hydrocarbon chain. Analysis of the electron localization and geometries of the carbon chains reveal the formation of C-Al-σ bonds with the chain growing towards the gas rather than C-Al-π bonds covering the γ-Al2O3(100) surface. This growth behaviour prevents catalysis poison during the initial stage of graphene nucleation.
Light-Induced Control of Voltage Gated Ion Channels
Authors: Palmisano Vito F. , Anguita-Ortiz Nuria , Faraji Shirin , Nogueira Juan Jose
Published: April 2022

Voltage gated ion channels are transmembrane proteins responsible for the generation and propagation of action potentials in excitable cells. They are key targets in receptor pharmacology, since the simple actions of opening and closing their pore with different kinetics or conductivity have been associated with a large number of channelopaties. Crystal structures of ion channels became available only in the last decades and, in combination with mutagenesis data, allowed the identification of drugs able to modulate ion conduction. However, most of the traditional modulators are not selective and present adverse side effects. Photopharmacology is establishing a new approach to overcome the problem of selectivity often present in voltage gated ion channels due to highly conserved binding regions among channels of the same subfamily. In this review, we describe the central pore region of Voltage gated sodium and potassium channels from a structural and pharmacological perspective, characterizing the binding mode of natural toxins and synthetic compounds able to physically occlude ion conduction. In addition, a bridge is created between classical pharmacology and photopharmacology, describing the approaches aimed to control the activity of voltage gated ion channels by photosensitive drugs.
Development of Online Media to Deliver Guidance and Counseling Services in during the Covid-19 Pandemic
Authors: Waroka Linda Ardiya
Published: April 2022

The condition of school from home provides a challenge for Guidance and Counseling teachers. Students begin to feel bored to talk to in monotonous, rigid conditions. Guidance and counseling innovation is intended as the ability to apply creative solutions to various problems and opportunities to improve the performance of GC services, so the purpose of this research is to find out the development of GC teacher services ( counseling guidance) in the Merdeka Learning era during the covid-19 pandemic. This study uses a qualitative research type. The data analysis used in ringing this article is library research. The results of the research on the development of GC teacher services are the use of online media such as zoom, gmeet, gform, hatsapp, google classroom, peer counselors, development of GC teacher abilities, development oftutorials self-healing and development of gadget constraints and student quotas
Potential Hospital Strategic Planning in the COVID-19 ‎Era: A Systematic Review
Authors: Amanda Pinta Tatyana , Ayuningtyas Dumilah , Simanjuntak Rhinza Seputra M.
Published: April 2022

The COVID-19 pandemic has had a negative impact on hospitals. Hospitals have to survive and make various modifications in an effort to adapt to uncertain conditions, even transform the hospital's strategic plan that has been made previously. This study aims to re-evaluate various hospital strategic plans and evaluate aspects that often change during a pandemic, as well as determine the potential for strategic planning that can be used. We initially conducted an English literature search using the electronic database, PROQUEST, Scopus, Pubmed, Science Direct, 2020-2021. After that, the study quality assessment and data extraction were carried out. A total of 1951 eligible articles were identified, The remaining 18 studies were screened. Subsequently, 10 articles were removed after a full-text review. Finally, 8 articles met the inclusion criteria for this review. Most of the hospitals in the sample show increasing and decreasing returns to scale. The inefficiency stems from the hospital's suboptimal scale, not from a lack of management ability to convert inputs into outputs. Public health centers develop systems for office support, infection control, hospital coordination, and outsourced inventory control. The impact of COVID-19 that can be felt by the community in the field of health services is the lack of availability of hospitals that can accommodate COVID-19 patients and non-COVID-19 patients. There are still many hospitals that still accept non-COVID-19 patients who have comorbidities, while hospitals also accept COVID-19 patients, one of which is asymptomatic people (OTG) who are difficult to detect. Efforts to respond to the pandemic from the start and then implement strategic measures are highly dependent on the resilience of hospitals. Strategic planning transformation can be a solution for hospital organizations to remain resilient and advanced in an uncertain era.
Factors Associated with Impaired Cognitive Function in the Elderly People
Authors: Rinaningsih Yani Sandra , Kridawati Atik , Ulfa Laila
Published: April 2022

The decline in cognitive function that occurs in the elderly can result in limitations in carrying out daily work, making dependence on others so that it can reduce the quality of life. The purpose of this study was to identify cognitive function disabilities and the factors that influence cognitive function diseases in the elderly in RW 01 Kelurahan Susukan Kecamatan Ciracas, East Jakarta. This study uses a quantitative method through a cross- sectional approach. The population in this study were the elderly aged ≥ 60 years, amount to 386 people. The research sample was 197 people. The independent variables in this study were age, gender, education level, history of degenerative diseases and physical activity and the dependent variable was cognitive function in the elderly. The data was collected using the MMSE (Mini Mental State Examination) and IPAQ (International Physical Activity Questionnaire) questionnaires. Data analysis was carried out by univariate, bivariate with Chi Square test and multivariate with multiple logistic regression test predictive model. The results of the study with variables that had a significant relationship were education level variables (p-value = 0.000), history of degenerative diseases (p-value = 0.019) and physical activity (p-value = 0.000). Variables that did not have a significant relationship with cognitive function were age (p-value=0.190 and gender (p-value=1,000). The results showed that most of the elderly had normal cognitive function and there was a relationship between the level of education, history of degenerative diseases and physical activity with the cognitive function of the elderly. Future research is expected to be able to conduct studies that focus more on a more diverse educational background and develop its relationship with cognitive and dementia incidence.
Determinant of Preventive Behavior COVID-19 Among Mothers in Ogan Ilir Regency, South Sumatera Indonesia
Authors: Razak Rahmatillah , Budiastuti Anggun , Ermi Nurmalia
Published: April 2022

Coronavirus disease 2019 (COVID-19 ) is an infectious disease caused by a new coronavirus (SARS-CoV-2) and currently become a great threat and public health consent worldwide, including in Indonesia. COVID-19 infected more than three hundred million people worldwide, causing more than five million deaths. This study aimed to assess the preventive behavior, knowledge, and history of COVID-19. A cross-sectional study was carried out using secondary data of field learning experience students by the Faculty of Public Health, Sriwijaya University in 2021, the population is all mothers who have toddler in Ogan Ilir Regency and the sampling method uses purposive sampling with 1850 mothers as a respondent in Ogan Ilir Regency, South Sumatera, Indonesia. Univariate analyses were used to see the distribution of variable and bivariate analysis conducted using the Chi-Square test with a significance level of 0.05 to see the association of the variable. The result shows that 0.6% of mothers infected with COVID-19 and 0.8% of mothers who had family were positive COVID-19. More than half of respondents, 52.4%, have good preventive behavior, and 48.6% have poor preventive behavior. 53.1% of respondents had good knowledge, and 46.9% had poor knowledge regarding COVID-19. Level of knowledge (P-value 0.001) and underlying health conditions or comorbidities (P-value) were factors related to good preventive behavior. Therefore, effort must be made to increase awareness and improve knowledge related to COVID-19 by health workers.
Identification of Waste Processing Methods in Bersinar Waste Bank Bandung, West Java
Authors: Mawaddah Nurul , Putra Febrian Rahmat Adias
Published: April 2022

Bersinar waste bank is one of the waste management units in Bandung. The Bersinar waste bank is a solution to reduce waste generation at the sarimukti TPA, Bandung. Waste managed by Bersinar waste bank is in the form of organic and inorganic waste. This study aims to identify the methods of processing waste and processing products at the bersinar waste bank in Bandung. This research is qualitative research. The stages of this research are problem identification, literature review, determination of research aims and objectives, data collection, data analysis and interpretation, and reporting. This research data collection is divided into two, namely primary data (observation) and secondary data obtained from books or scientific journals (literature review). The results of the identification of waste processing methods at the bersinar waste bank can be concluded that the bersinar waste bank uses physical, biological, and thermal methods. The first method to reduce waste is to process organic waste using maggot technology as a decomposer of organic waste into compost. the second method is the use of a bottle press to produce a cube of bottle waste. The third method is processing used baby diaper waste using a hydrothermal reactor machine and processing it into fibre to produce pock brick.
BENEFITS OF USING SMART GAS MONITORING SYSTEMS IN OIL AND GAS INDUSTRY USING INDUSTRIAL INTERNET OF THINGS
Authors: Sankar Muni , B Booba
Published: April 2022

The industrial Internet of Things (IIoT) is the use of Internet of Things technologies to transform manufacturing and industrial processes. Also known as “industry 4.0”, Industrial IoT integrates big data and machine learning technologies to harness the sensor data, M2M communication and Automation technologies. The world has been rapidly adapting smart technologies and connecting everything, which implies everything. To provide the greatest quality service to its consumers, many establishments such as hotels, canteens, and enterprises use flammable gases such as LPG, carbon dioxide, ammonia, and others. The usage of these gases has undoubtedly made technologies smarter, but it also comes with a risk aspect that poses a threat to human life. As a result, safety becomes a major concern. As a result of this element, a gas detection system was deemed necessary in such accident-prone areas, allowing for continuous monitoring of any form of leakage, regardless of human senses.
IMPLEMENTATION OF WEARABLE DEVICE FOR MONITORING ALZHEIMER’S PATIENTS
Authors: M Rashmi , Kotresh Oli Anusha , G Akshay , H D Chandan , J Yashwanth
Published: April 2022

Thousands of persons with Alzheimer's disease and other cognitive problems go missing every year. As a result, the person with dementia must frequently keep track of their current location. As a result, a dependable and affordable monitoring system is required to improve the quality of life of these individuals and their families. Individuals and their caretakers must be constantly monitored and cared for, as well as intervene and provide support, putting a great financial and human load on them. Interconnected sensing technologies, such as wearable devices and Internet of Things (IoT) devices, offer a potential solution for objective, dependable, and remote monitoring, assessment, and support throughout one's lifetime, with the help of the environment. This suggested wearable device would combine GPS systems with a microcontroller to provide real-time monitoring of Alzheimer's sufferers when they leave their homes, ensuring their safety. The fall is detected, the caregiver is alerted, and emergency care can be given in the event of a patient collapsing. On the screen, there are also simple routine reminders.
A comparative study of intrathecal dexmedetomidine and fentanyl as adjuvants to bupivacaine to provide prolonged postoperative analgesia
Authors:   Associate Professor,Department of Anaesthesia, Navodaya Medical College, Raichur, Karnataka, INDIA., Subhash V Mashalkar
Published: April 2022

Background and Objectives: Mixing adjuvants with hyperbaric bupivacaine for intrathecal injection is an practice since long time for reducing dose requirement of bupivacaine and prolongation of duration of action. Short acting liophilic opioid fentanyl and selective apha2 agonist dexmedetomidine is used to reduce dose requirement of bupivacaine and its adverse effects and also to prolong postoperative analgesia. The main objective of the study is to compare efficacy of intrathecal adjuvants i.e., dexmedetomidine and fentanyl with hyperbaric bupivacaine to assess postoperative analgesia and side effects Materials and Methods: This prospective, randomized, double blinded and placebo control study was carried out in a tertiary health care centre on 105 patients by randomly allocated into 3 groups and were assigned to receive one of the three intrathecal drugs i.e., Group D (n=35) received mixture of 0.5% hyperbaric bupivacaine (2.5ml) with Dexmedetomidine (5mcg) intrathecally, Group F(n=35) received mixture of 0.5% hyperbaric bupivacaine (2.5ml) with (25mcg) of fentanyl intrathecally and Group B received 0.5% hyperbaric bupivacaine (2.5ml) and 0.5ml normal saline intrathecally. All the solutions were made up to volume of 3ml in a 5ml syringe. Results: The duration of analgesia was significantly longer in Group D (545±61.94) compare to Group F (437.94±43.32) and Group B (263.97±22.88). Conclusion: Dexmedetomidine an adjuvant to bupivacaine (H) found to be very attractive alternative to fentanyl as it provides excellent postoperative analgesia