bluuebunny/crossref_metadata_2025 huggingface dataset:
Biogeochemistry of soils, sediments, and surface waters across the upland to wetland gradient of coastal interfaces
Authors: Myers-Pigg Allison , Pennington Stephanie , Homolka Khadijah , Lewis Allison , Otenburg Opal , Patel Kaizad , Regier Peter , Bowe Madison , Boyanov Maxium , Conroy Nathan , Day Donnie , Norris Cooper , O'Loughlin Edward , Roebuck Jr. Jesse , Stetten Lucie , Bailey Vanessa , Kemner Kenneth , Ward Nicholas , Consortium EXCHANGE
Published: May 2023

Transferable and mechanistic understanding of cross-scale interactions is necessary to predict how coastal systems respond to global change. Cohesive datasets across geographically distributed sites can enable a mechanistic understanding of coastal ecosystem control points and examine how geographically transferable this knowledge is. To address the above research objectives, data were collected by the EXploration of Coastal Hydrobiogeochemistry Across a Network of Gradients and Experiments (EXCHANGE) Consortium– a regionally distributed network of researchers that collaborated on experimental design, methodology, collection, analysis, and publication. The EXCHANGE Consortium collected samples from 52 coastal terrestrial-aquatic interfaces (TAIs) during Fall of 2021. At each site, samples collected include soils from across a transverse elevation gradient (i.e., coastal upland forest, transitional forest, and wetland soils), surface waters, and nearshore sediments. The data described herein aims to characterize the baseline distribution and chemical forms of carbon, nutrients, iron redox and mineralogy across research sites in the Great Lakes and Mid-Atlantic regions (Chesapeake and Delaware Bays) of the continental USA. This first campaign measures surface water quality parameters (e.g., conductivity, pH, ORP, alkalinity, and total suspended solids); bulk geochemical parameters on water, soil, and sediment samples (e.g., carbon, nutrient, and ionic concentration and composition); physicochemical parameters of sediment and soil (soil pH, conductivity, bulk density, water retention); and the rate of O2 consumption in inundated sediment and soil samples. Future campaigns will focus on building off these baseline datasets to enable a mechanistic understanding of coastal ecosystem biogeochemical control points.
Perceptions of Grammar-Translation Method and Communicative Language Teaching Method Used in English Classrooms
Authors: Wu Huaijin , SU HUANAN , Yan Mengjiao , Zhuang Qingjie
Published: May 2023

The Grammar-Translation method and Communicative Language Teaching (CLT) were both used in English classrooms in high schools in China. This research is a meaningful attempt to investigate the high school student's perceptions of the two mentioned language teaching methods and corresponding learning activities in terms of enjoyment and effectiveness so that their voices can be heard. By applying a quantitative research design using the descriptive approach, questionnaires were answered by the Grade 10 students as well as an informal interview with the teacher. It was found that the grammar-translation method is more favorable than CLT by both the students and the teacher. The implication is that CLT should be given more chances to be practiced by the teachers and students under the new curriculum reform.
Exploring Interactions between Awqāf and Digital Data
Authors: Belabes Abderrazak
Published: May 2023

The aim of the study is to investigate the interactions between the phenomena of awqāf and digital data through exploratory research that is conducted in this occasion on an unaddressed topic. The study sheds light on the structural phenomena that digital transformation imposes on life in all its aspects beyond the prevailing approach that deals with technique in terms of advantages and disadvantages. The study is inspired by the modeling of natural systems, an analytical framework to provide a basis for the interaction between awqāf and digital data in terms of the balance between efficiency and resilience, in addition to a prospective model based on the distinction between open and closed systems: reliance on knowledge generates open systems through a multitude of bifurcations, while reliance on technique alone creates closed systems that lead to self-destruction. Despite the huge media hype in social networks, digital data should not replace interactions in the natural ecosystems that awqāf have sustained over the centuries by fulfilling the rights of God and those of living creatures. Keywords: Awqāf, Data, Digital Transformation, Efficiency and Resilience, Open and Closed Systems
Cultural Identity of And Implications for Later Generational Hispanic and Latino Populations In The United States
Authors:   , Bustamante Tara
Published: May 2023

This study explores the Hispanic and Latino/x/e cultures within the United States, with a particular focus on the concept of identity within these communities and its implications for third and later generations. Data were collected during the pandemic via an online survey and art directive. The student researcher used the Identity Denial Scale (Albuja et al., 2019) to measure how often the participants’ identity is denied within the United States and then used an art therapy prompt to invite participants to create their own self-portrait in conjunction with their authentic self and self-image. Qualitative data were also used in response to a vignette portraying a character experiencing imposter syndrome. Whereas 51 people signed the consent form for the project, 12 completed the study. First-generation (n = 3), second-generation (n = 6), and third- generation (n = 3) individuals identifying as Latina or Hispanic participated. First- and second- generation participants scored low but still had problems with their identity. Third-generation participants scored the highest on the Identity Denial Scale but coped well with due to familial ties and support. Overall, based on the qualitative data collected, the findings of this small study showed that the younger participants would benefit from therapeutic intervention. The third- generation conveyed the feeling that their identity was denied but they conveyed the notion that their place was secure.
Biomedical research and publication: what the beginners need to know
Authors: Rahim Muhammad Abdur
Published: May 2023

Abstract not available
BIRDEM Med J 2023; 13(2): 65-66
Immunohistochemical expression of human epidermal growth factor receptor 2 (HER2/neu) in colorectal carcinoma: experience in a tertiary care hospital of Bangladesh
Authors: Syeed Sifat , Afroze Nazma , Jannat Shakila , Ahmed Mousumi
Published: May 2023

Background: Among various immunological markers of colorectal carcinoma, the human epidermal growth factor receptor 2 (HER2/neu) is a significant one. Overexpression of HER2/neu in breast cancer has already been established as a poor prognostic marker and trastuzumab (a monoclonal antibody against HER2/neu) has been shown to increase the patient survival. The success of anti-HER2 (Herceptin) therapy in breast cancer has led to the evaluation of HER2/neu expression in colorectal and other cancers. The aim of the study was to determine the expression of HER2/neu in colorectal carcinoma.
Methods: This cross-sectional study included 97 diagnosed cases of colorectal carcinoma and was conducted in the Department of Pathology, BIRDEM General Hospital, Dhaka from September 2018 to August 2020. Sections were taken from paraffin blocks for routine hematoxylin and eosin (H&E) stain and immunohistochemical stain with HER2/neu antibody. Relevant clinical and microscopic data including age, sex, tumor site and tumor size were collected and recorded.
Results: HER2/neu expression was observed in 47.4% (46) cases in this study. Among which 28.9% cases were found strongly positive (Score 3+) and 18.6% cases were found weakly positive (Score 2+). The mean age of colorectal carcinoma patient was 50.54±14.32 years and the highest expression of HER2/neu was found in 21- 30 years age group. The tumor was mostly (66.0%) located in the colon whereas HER2/neu expression was more in rectum (54.5%). The tumor size was  ³5 cm in 64.9% cases while positive expression of HER2/neu was more in tumors <5 cm in size (50.0%). No statistically significant correlation of HER2/neu expression was found with age, sex, tumor site and size.
Conclusion: Expression of HER2/neu has been observed in nearly half of colorectal carcinoma patients with strongly positive in almost 29% cases.
BIRDEM Med J 2023; 13(2): 81-87
Uterine artery Doppler screening in 18 to 24 weeks of pregnancy for prediction of adverse maternal outcome
Authors: Sengupta Ruma , Shermin Sahana , Shelly Samsad Jahan
Published: May 2023

Background: Uterine artery Doppler velocimetry (UADV) analysis has been extensively studied in the second trimester of pregnancy as a predictive investigation for the future development of adverse feto-maternal outcome. This study was designed to assess the association between findings of uterine artery Doppler velocimetry with maternal outcome.
Methods: This was a prospective observational study among the pregnant women attending the inpatient and outpatient departments of Obstetrics and Gynecology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Segunbagicha, Dhaka, from July 2021 to December 2021. A total of 31 women with singleton pregnancy were enrolled in this study at their 18-24 weeks of gestation. After obtaining informed written consent, data were collected from patients on variables of interest using a semistructured questionnaire. All the respondents underwent uterine artery Doppler velocimetry at 18 to and 24 weeks of gestation and were followed up to observe its relationship with feto-maternal outcome. Descriptive and inferential analyses were done using SPSS v.21.
Results: More than half (51.6%) of the subjects belonged to 30 years and above. The mean age was found 29.71±4.8 years with ranged from 21 to 40 years. Most (96.8%) of the subjects had diabetes mellitus and only 32.3% subjects had hypertension. More than half (54.8%) had adequate diastolic flow and 32.3% subjects had diastolic notch. Majority (64.3%) of the respondents with decreased diastolic flow had preeclampsia. Majority (70.0%) of the respondents with diastolic notch also developed preeclampsia. All these findings were statistically significant (p<0.05).
Conclusion: In conclusion, pregnant women who have normal UADV finding at their 2nd trimester possess less chance of development of adverse maternal outcome.
BIRDEM Med J 2023; 13(2): 92-97
Reviewers of the current issue Vol.13(2)
Authors: Rahim Muhammad Abdur
Published: May 2023

Abstract not available

BIRDEM Med J 2023; 13(2): 121
Stoma Reversal : A Restropective Study of 36 Cases at A Non-Government Hospital
Authors: Alam Md Badiul , Yasmin Sabina , Rab Md , Nazamul Hoque Md
Published: May 2023

Background : Formation of intestinal stoma is a common surgical practice. In this study, we aim to study the indications for stoma creation, complications of stomas, timing and methods of stoma reversal, reasons for any delays and post-reversal complications.
Material and methods: This is a restropective study Charts of patients who underwent stoma creation and reversal over a 3 year period from January 2018 to December 2020 at Banghbandhu Memorial Hospital are included in this study.
Results: A total of 49stomas were created out of which 36 were reversed. Overall pre-takedown complications were 26 % and post-takedown complications were 30% most of which were minor complications, not requiring major interventions. There was no significant difference in outcome due to early vs. late reversal, types of anesthesia or reversal technique.
Conclusion: Reversal of temporary stomas can be done safely at an early date, with no demand of special anesthesia, requiring minimal access to the abdomen and with safe early discharge without expecting serious complications or readmissions.
IAHS Medical Journal Vol 5(1), June 2022; 78-81
Prospects for Regulating the Right to Posthumous Reproduction in the Context of War in Ukraine: Foreign Experience and Formation of Legal Support for the Realisation of Reproductive Rights of Military Personnel
Authors: Kvit Nataliia
Published: May 2023

Background: This article focuses on the analysis of posthumous reproduction regulation perspectives in Ukraine through the lens of war risks, considering how the reproductive rights of male and female military personnel could be best guaranteed. In particular, the peculiarities of different legal and ethical problems, like formal requirements for the disposal of reproductive biological material and embryos in case of death, as well as issues of inheritance and establishment of paternity/maternity, are disclosed. The problem of posthumous reproduction legal regulation unification in the application of technology of posthumous reproduction is considered. Attention is also focused on the possibility of reproductive tourism for the sake of posthumous reproduction.
Methods: The methodological framework of the study was a range of philosophical, general, and legal methods. The-dialectical method of cognition made it possible to investigate the problem’s social and ethical content and legal form and conduct a systematic theoretical and legal analysis of the applying posthumous reproduction in practice, especially under the scope of risks for health and life, which are conditioned by war in Ukraine. Thanks to the comparative method, the diversity of posthumous reproduction regulation models worldwide was investigated and compared with current Ukrainian draft Laws, particularly considering which of the models listed could best fit the Ukrainian law and moral traditions and the current situation in our country. With the help of a formal-legal approach, the content and peculiarities of contractual and legal practice were analysed.
Results and Conclusions: It was comprehensively considered that posthumous reproduction should be allowed and regulated in the special law of Ukraine, which must perform the clear and justified legal framework to protect the rights of all participants of these sensitive relationships: consumers and performers of these reproductive services, as well as so-called postmortal children.
Pelatihan Pengelolaan Dan Pelayanan Pada Homestay Di Desa Tanjung Jaya Pandeglang
Authors: Djunaid Ika Suryono , Sofiani Sofiani , Rosanto Stephanie , Soeprapto Vishnuvardhana S , Natalia Dessy
Published: May 2023

Abstract: Tanjung Jaya Village is an educational tourism village located in the Tanjung Lesung destination, Pandeglang Regency, Indonesia. Tanjung Jaya Village, surrounded by beautiful beaches and hills, is the choice of a fun and relaxed tourist village for both domestic and foreign tourists. However, the people of Tanjung Jaya Village do not yet understand the basics of hospitality and tourism in implementing homestays. The purpose of this community service activity is to provide an understanding of Basic Knowledge related to the development of Community Based Tourism-based Tourism Villages in homestay management and Homestay Management and Service Systems. The method used here is in the form of training, while the stages start from preparation, implementation, and evaluation in the form of feedback from participants. The results of the questionnaire from the Educative category (Useful Community Service Activities and answering Participants' needs) averaged 81%, Objective (Material delivered according to conditions and problems faced by participants) averaged 86% Accountable (Material delivered clearly and understandable by the participants) the average is 82%, Transparent (Participants are actively involved in the implementation of activities) the average is 87%. Keywords: Homestay, Training, Tanjung Jaya Abstrak: Desa Tanjung Jaya merupakan salah satu desa wisata edukasi yang terletak di destinasi Tanjung Lesung, Kabupaten Pandeglang, Indonesia. Desa Tanjung Jaya, dikelilingi oleh pantai dan perbukitan yang indah, merupakan pilihan desa wisata yang menyenangkan dan santai bagi wisatawan domestik maupun mancanegara. Namun masyarakat Desa Tanjung Jaya belum memahaminya dasar-dasar hospitality dan pariwisata dalam pelaksanaan homestay. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk memberikan pemahaman Pengetahuan Dasar terkait pengembangan Desa Wisata berbasis Community Based Tourism dalam pengelolaan homestay dan Sistem Pelayanan dan Manajemen Homestay. Metode yang digunakan disini adalah dalam bentuk pelatihan, adapaun tahapannya dimulai dari persiapan, pelaksanaan, evaluasi berupa uman balik dari peserta. Hasil kuesioner dari katagori Edukatif (Kegiatan Abdimas bermanfaat dan menjawab kebutuhan Peserta) rata-rata adalah sebesar 81% , Objektif (Materi yang disampaikan sesuai dengan kondisi dan masalah yang dihadapi peserta) rata-rata adalah sebesar 86% Akuntabel (Materi disampaikan dengan jelas dan dapat dipahami oleh peserta) sebesar  rata-rata adalah sebesar 82%, Transparan (Peserta dilibatkan secara aktif dalam pelaksanaan kegiatan) rata-rata adalah sebesar 87%. Kata kunci: Homestay, Pelatihan, Tanjung Jaya
Pelatihan Destinasi Wisata Bersih Melalui Teknologi Media Digital Dalam Menun-jang Pariwisata Desa Cipta Karya
Authors: Yuliana Yuliana , Siahaan Shanti Veronica  Br , Benny Petrus
Published: May 2023

Abstract: Cipta Karya Village is located in Bengkayang Regency, a small village that has interesting natural attractions for tourist visits. But there is still minimal awareness of visitors who are responsible for waste. Therefore, a community service program was held to manage waste into new goods so as to produce products to increase the economy of rural communities by utilizing digital media technology as a means of tourism promotion. This service aims to provide clean tourism education through waste management programs into new goods, counseling about (content) upgrades, and social media accounts as well as technical training in compiling promotional content based on digital media technology. The method of community service activities applied Socialization and discussion, training and mentoring, and evaluation, through evaluation aims to see the process of training activities in the long term by looking at the number of partner group participants when managing tourism. The results obtained in this service are increasing the insight of the village community about the use of waste in new goods. Visitors' concern for the tourist destinations visited and the use of digital media, namely the creation of clean tourism content to be published on the YouTube channel.      Keywords: digital media; net travel; tourist
PENGARUH PENERAPAN SISTEM AKUNTASI KEUANGAN PEMERINTAH DAERAH DAN KOMPETENSI SUMBER DAYA MANUSIA TERHADAP KUALITAS INFORMASI LAPORAN KEUANGAN PEMERINTAH DAERAH (STUDI KASUS PADA SATUAN KERJA POLDA KEPULAUAN RIAU)
Authors: Putra Dafriansyah , Permata Hati Ravika
Published: May 2023

Berdasarkan basil analisis data dan pembahasan mengenai pengaruh pengaruh penerapan system akuntansi keuangan pemerintah daerah (XO dan kompetensi sumber daya manusia terhadap kualitas informasi laporan keuangan pemeriniah daerah (Y) pada Satuan Kerja Polda Kepri. Analisis yang dilakukan menggunakan analisis berganda (multiple regression) dengan SPSS 17. Dan sampel yang digunaknn sebanyak 32 responden yang merupakan pegawai yang melaksanakan tugas dan fungsi tata usaha keuangan pada Satuan Kerja Polda Kepulauan Riau yaitu pada bagian keuangan Polda Kepulauan Riau (BidKeu). Hasil pengujian dan pembahasan yang telah dilakukan sebelumnya, maka dapat diambil kesimpulan: Hasil analisis variabel pemanfaatan sistem informasi akuntansi keuangan daerah diperoleh nilai t hitung sebesar 4.193 dengan probabilitas 0,000. Dengan t hitung 4.193 lebih besar dari t-tabeIuos(32) 1.69726 atau probabilitas 0.000 lebih kecil dari 0.05; maka Ho ditolak yang berarti bahwa variabel pemanraatan sistem informasi akuntansi keuangan daerah secara parsial atau individu berpengaruh signifikan terhadap kualitas informasi laporan keuangan pada Satuan Kerja polda Kepri. Hasil pengolahan variabel kompetensi sumber daya manusia diperoleh nilai t hitung sebesar 4.237 dengan probabilitas 0,000. Dengan t hitung 4.237 lebih besar dari t-tabel 1.69726 atau probabilitas 0.000 lebih kecil dari 0.05; maka Ho ditolak yang berarti bahwa variabel kompetensi sumber daya manusia secara parsial atau individu berpengaruh signifikan terhadap kualitas informasi laporan keuangRn pada Satuan Kerja polda Kepri. Diperoleh hasil analisis untuk nilai F adalah sebesar 57.%2 dengan probabilitas sebesar Nilai F table adalah sebesar 3.32. Oleh karena itu dengan nilai F hitung lebih besar dari F table yaitu 57.662 3.32 atau probabilitas F hitung lebih kecil dari 0.05 maka HO ditolak dan HI diterima. Hal tersebut membuktikan bahwa terdapat pengaruh yang signifikan antara penerapan system akuntansi keuangan pemerintah daerah (XI) dan kompetensi sumber daya manusia (X2) terhadap kualitas informasi laWran keuangan pemerintah daerah (Y) pada Satuan Kerja Polda Kepri.Kata Kunci: Sistem Akuntansi, Laporan Keuangan, Pemerintah Daerah.
PENGARUH CUSTOMER RELATIONSHIP MANAGEMENT, NILAI NASABAH, KEPERCAYAAN NASABAH DAN KUALITAS PELAYANAN TERHADAP LOYALITAS NASABAH PADA PT BANK BUKOPIN CABANG BATAM
Authors: Tibrani Tibrani , Anggraini Dini , Tamrin Fannisa Carlyna
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh Customer Relationship Management, Nilai Nasabah, Kepercayaan Nasabah, dan Kualitas Pelayanan terhadap Loyalitas Nasabah Pada PT Bank Bukopin Cabang Batam. Populasi pada penelitian ini merupakan nasabah Bank Bukopin yg berjumlah 26.687 nasabah. Sampel yg dipengaruhi menggunakan secara acak sampling berjumlah 100 responden. Hasil pengujian menerangkan bahwa customer relationship management, nilai nasabah, & kualitas pelayanan berpengaruh positif dan signifikan terhadap loyalitas nasabah secara parsial. Pengujian ini pula menerangkan bahwa customer relationship management, nilai nasabah, dan kualitas pelayanan berpengaruh positif & signifikan terhadap loyalitas nasabah secara simultan. Pengujian ini pula menerangkan bahwa nilai nasabah berpengaruh positif &signifikan terhadap loyalitas nasabah secara parsial & secara simultan. Variabel loyalitas nasabah bisa dijelaskan sang variabel customer relationship management, nilai nasabah,& kualitas pelayanan sebanyak 41.6% sisanya sebanyak 58,4% dijelaskan sang variabel-variabel lain yg nir dimasukkan pada contoh penelitian ini.
ANALISIS KEBIJAKAN KEPALA SEKOLAH DALAM HAL PENGADAAN DAN KOMPENSASI GURU TERHADAP PENYELENGGARAAN PENDIDIKAN DI LINGKUNGAN YAYASAN SERBA BAKTI SURYALAYA
Authors: Makarim Siti Amirah
Published: May 2023

Penyelenggaraan pendidikan di Yayasan Serba Bakti memberikan wewenang kepada kepala sekolah untuk membuat kebijakan khususnya mengenai pengadaan dan kompensasi guru berpotensi menghasilkan keberagaman. Penelitian ini bertujuan menganalisis secara komprehensif tentang kebijakan kepala sekolah TK, SMP, MTs, MA, SMA dan SMK dalam hal tersebut. Penelitian ini menggunakan metode kombinasi berjenis sequential explanatory yang diawali dengan penggunaan metode kuantitatif dilanjutkan dengan metode kualitatif. Data kuantitatif diambil dari hasil kuesioner dengan sampel 137 guru sebagai responden. Kuesioner dikembangkan melalui tahap review literatur, mengkonstruksi instrumen, menetapkan validitas isi, dan uji coba lapangan. Data kualitatif tentang dasar pertimbangan kebijakan diperoleh melalui wawancara kepala sekolah, observasi dan dokumentasi. Data hasil penelitian menunjukkan perbedaan yang signifikan antar kebijakan kepala sekolah (0,05) dengan nilai 0,00 yang diartikan kebijakan di setiap sekolah berbeda. Data kualitatif juga menunjukan keberagaman. Kebijakan pengadaan guru di setiap sekolah berada pada kategori kurang baik dan cukup baik (1,69-2,38), sementara kebijakan kompensasi guru berada pada kategori kurang baik (1,33-1,63). Secara keseluruhan kebijakan kepala sekolah mengenai pengadaan dan kompensasi guru berada pada katagori cukup baik sebesar 2,05. Dalam hal ini diharapkan yayasan bisa lebih berperan dalam membuat sistem yang dapat mengatur hal tersebut sehingga penyelengaraan pendidikan menjadi lebih baik.
Exploration of Environmental Literacy in the Kampung Warna-Warni Jodipan Malang as a Source of Learning for Biology
Authors: Qomariansyah Intan Nurul , Husamah H. , Miharja Fuad Jaya
Published: May 2023

This research aims to analyze the environmental literacy of the community in Kampung Warna-warni Jodipan (KWJ). Environmental literacy is conducted to determine the community's ability to understand and maintain the environment to ensure its balance and prevent pollution. Knowledge and attitudes are important aspects used to measure environmental literacy. This research was conducted on KWJ community involving 83 people as research samples. Data were collected through questionnaires, interviews, and observations using Google Form. Data analysis used Guttman Scale and Likert Scale. The results of data analysis according to the Guttman Scale with a moderate score range (11-16) showed that the community's knowledge is not yet fully maximal in understanding environmental literacy, but with KWJ, the attitudes shown by the community begin to emerge to maintain and preserve their environment. The results of this research can be used as a learning resource for biology in high school class X. This research can be used as a step to improve understanding of environmental literacy.
Human Intelligence versus AI: Implications for Emotional Aspects of Human Communication
Authors: Oritsegbemi Omafume
Published: May 2023

The affective computing approach of artificial intelligence has made it possible for machines to not only think, behave and communicate like humans, but to also emote like humans. This dimension of AI is substituting human capacities due to its benefits in diverse spheres of life. While studies abound in the comparison between AI and human intelligence in terms of their cognitive capacities, very few have focused on the emotional aspect. This study therefore, utilized secondary data by reviewing empirical studies to examine the implications of AI in the emotional aspects of human communication. The study is anchored on basic emotion theory and technological determinism which enunciate the fundamentals of emotional AI and its effects. The paper argues that the complexity and subjectivity of human intelligence and emotion cannot be adequately replicated by AI as it lacks innate emotion and the ability to understand abstracts. It recommends media literacy skills for users and ethical guidance for technological companies designing AI to ensure it is less detrimental to human and the society.
O cuidado da equipe interdisciplinar como estratégia de priorização da saúde do idoso
Authors: Batista Weslley dos Santos
Published: May 2023

O objetivo do artigo foi conhecer o cuidado da equipe interdisciplinar para com os Idosos por meio do acompanhamento sobre as atividades dos idosos em Centros de convivências das regiões Norte, Nordeste e Sul. Centro de Convivência da região Nordeste do Brasil. Centro Geriátrico da região Sul do Brasil. Essas instituições são de suma importância para melhoria na qualidade de vida dos idosos, tendo em vista o acompanhamento das atividades desenvolvidas, buscando identificar na população idosa sua percepção na participação dos grupos de convivência, e as melhorias obtidas com as atividades realizadas. A metodologia enfatiza um estudo qualitativo e quantitativo, por meio de levantamento qualitativo, descritivo com amostras transversais, a partir desses dados foram levantados estudos literários, com a análise de dados secundários a respeito da utilização do conteúdo de forma ética e profissional para com idosos. Vale destacar os grupos de convivências como suporte para melhoria na qualidade de vida dos idosos, uma vez que promovem a participação, através de diversas atividades, o qual se faz refletir sobre o processo de envelhecimento, a qualidade de vida e a valorização da própria vida. As atividades desenvolvidas pelo Centros de Convivências são de suma importância para os idosos. Pois, com essas práticas desenvolvidas eles têm uma melhor qualidade de vida, conseguem fazer novas amizades que também são fundamentais, e passam a não se sentir mais inútil, além do desenvolvimento para a sua autonomia, e autoestima, automaticamente tornando-se mais felizes.
Baiq Nova Aprilia Azamti HUBUNGAN TINGKAT PENGETAHUAN IBU HAMIL TENTANG MANFAAT TABLET TAMBAH DARAH (Fe) DENGAN KEPATUHAN MINUM TABLET TAMBAH DARAH DI PUSKESMAS PARAMPUAN KABUPATEN LOMBOK BARAT
Authors: NOVA BAIQ NOVA APRILIA AZAMTI
Published: May 2023

ABSTRAK

 

Tablet tambah darah yang mengandung zat besi (Fe)adalah salah satu unsur pembentuk hemoglobin (Hb)yang berfungsi sebagai pengikat oksigen yang sangat dibutuhkan dalam metabolisme sel dalam tubuh. Pada masa kehamilan wanita akan mengalami pengenceran sel darah merah sehingga memerlukan tambahan zat besi 20 mg per hari untuk meningkatkan pembentukan sel darah merah (hemoglobin). (Rasmaliah,2014).Salah satu upaya yang dilakukan untuk mencegah terjadinya anemia pada ibu hamil melalui konsumsi tablet tambah darah minimal 90 tablet selama kehamilan, namun kenyataanya upaya ini tidak semua ibu hamil minum tablet tambah darah sesuai anjuran yang ada. (Hani 2011)

Penelitianya itu untuk mengetahui bagaiman hubungan tingkat pengetahuan ibu hamil tentang manfaat tablet tambah darah (Fe) dengan kepatuhanminumi Tablet Tambah Darah di Puskesmas Parampuan Desain penelitian yang digunakan dalam penelitian ini adalah Diskriptif Analtik dengan pendekatan cross sectional. Besar Sampel dalam penelitian ini adalah 32 responden yang ditentukan dengan menggunakan teknik accidental sampling. Berdasarkan hasil penelitian dengan menggunakan uji statistic sperman rank dengan tingkat signifikan ? sebesar 5% (0,05) didipatkan nilai sperman rank sebesar 0,457 dan p-Value 0,065, hal ini menunjukkan nilai p < 0,05 (0.065 < 0.05) artinya ada hubungan tingkat pengetahuan ibu hamil tentang manfaat tablet tambah darah (Fe) dengan kepatuhan minum tablet tanbah darah di Puskesmas Parampuan dengan tingkat kekuatan hubungan yang sedang.

Berdasarkan hasil penelitian dapat disimpulkan bahwa kepatuhan ibu hamil minum tablet tambah darah (Fe) didukung oleh tingkat pengetahuan ibu hamil. Tingkat pengetahuan yang baik akan meningkatkan kepatuhan ibu hamil untuk patuh mengkonsumsi tablet tambah darah di Puskesmas Parampuan.

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Kata Kunci : Tingkat pengetahuan, Tablet Tambah Darah, Kepatuhan
FORMULASI SPRAY HAND SANITIZER ORGANIK DARI KOMBINASI EKSTRAK DAUN SIRIH HIJAU (Piper betle L.) DAN DAUN LIDAH BUAYA (Aloe vera) TERHADAP Staphylococcus aureus
Authors: Wulan Ratia Ratulangi Wulan Ratia Ratulangi
Published: May 2023

Penyakit virus corona 2019 (corona virus disease/COVID-19) sebuah nama baru yang diberikan oleh Wolrd Health Organization (WHO) bagi pasien dengan infeksi virus novel corona 2019 yang pertama kali dilaporkan dari kota Wuhan, Cina pada akhir 2019. Pada masa pandemi Covid-19, menjaga kerbersihan dan kesehatan adalah hal yang wajib dilakukan. Hand sanitizer merupakan alternatif dari sabun cuci tangan yang dapat berfungsi sebagai cairan antiseptik, hand sanitizer menjadi salah satu item wajib yang harus dimiliki untuk menjaga kebersihan, baik setelah atau sebelum memegang sesuatu. Tujuan dari penelitian ini adalah untuk mengetahui fomulasi spray hand sanitizer organik dan konsentrasi paling efektif dari formulasi spray hand sanitizer organik dari kombonasi ekstrak daun sirih hijau (Piper betle L.) dan daun lidah buaya (Aloe vera) terhadap Staphylococcus aureus. Penelitian ini adalah penelitian true eksperimental untuk mengetahui kombinasi ekstrak daun sirih hijau dan daun lidah buaya dalam bentuk formulasi spray hand sanitizer terhadap bakteri Staphylococcus aureus, dengan menggunakan pendekatan kuantitatif yang  dilaksanakan di Laboratorium Obat Tradisonal dan Laboratorium Biologi kampus Politeknik Medica Farma Husada Mataram pada bulan Desember 2021. Populasi dan sampel dalam penelitian ini adalah daun sirih hijau (Piper betle L.) dan daun lidah buaya (Aloe vera). Data dalam penelitian ini merupakan data primer yaitu observasi atau pengamatan langsung daya hambat hasil uji aktivitas antibakteri kombinasi daun sirih hijau dan daun lidah buaya terhadap pertumbuhan staphylococcus aerus.

Berdasarkan hasil penelitian tentang Formulasi spray organik kombinasi ekstrak daun sirih hijau dan daun lidah buaya sebagai Hand sanitizer memiliki efektivitas antibakteri terhadap bakteri Staphylococcus aureus dan Konsentrasi paling efektif dari formulasi spray  kombinasi adalah konsentrasi 30% dengan nilai hambatan 7,62 mm yang merupakan daya hambat sedang.

Pada penelitian yang selanjutnya perlu dikembangkan penelitian tentang Formulasi spray organik kombinasi ekstrak daun sirih hijau dan daun lidah buaya dalam bentuk sediaan farmasi yang lainnya, dan dilakukan perbaikan untuk formulasi sediaannya.
Case Report of Pulmonary Embolism with Right Ventricular Strain in a Young Female
Authors: Walker Yvonne , Chiou James P. , Diaz-Miret Miguel
Published: May 2023

Acute pulmonary embolism (PE) is when one or more thrombus travel to the lungs and obstruct the pulmonary artery or one of the branches of the pulmonary tree, producing signs and symptoms immediately after the obstruction. Saddle pulmonary embolism (SPE) is a rare type of acute PE that can lead to hemodynamic instability and death. The incidence of pulmonary embolism increases with age. In women, the risk of PE increases with pregnancy, hormonal contraceptives, and hormone replacement therapy. In this case, the patient was in her forties and presented with a sudden episode of continuous dyspnea that worsened over four hours. The dyspnea was associated with palpitations and diaphoresis. The clinical scoring tools had a low pre-test probability for PE. The patient had no risk factors for PE other than being obese. Significant laboratory workup showed troponin of 0.10, D-dimer of 8.10, and a B-type natriuretic peptide (BNP) of 1,160. Her computed tomography angiography (CTA) showed extensive pulmonary emboli in the bilateral main and segmental pulmonary arteries, with findings consistent with right heart strain. The patient was managed with an unfractionated heparin loading dose in the ED based on her weight, followed by a heparin drip. Then, the patient was transferred to a tertiary medical center for further interventions. Prompt recognition and treatment of a submassive PE are fundamental to improving patient mortality and morbidity.
Modeling visceral leishmaniasis and tuberculosis co-infection dynamics
Authors: Egbelowo Oluwaseun F. , Munyakazi Justin B. , Dlamini Phumlani G. , Osaye Fadekemi J. , Simelane Simphiwe M.
Published: May 2023

The co-infection of visceral leishmaniasis (VL) and tuberculosis (TB) patients pose a major public health challenge. In this study, we develop a mathematical model to study the transmission dynamics of VL and TB co-infection by first analyzing the VL and TB sub-models separately. The dynamics of these sub-models and the full co-infection model are determined based on the reproduction number. When the associated reproduction number (R1) for the TB-only model and (R2) for the VL-only are less than unity, the model exhibits backward bifurcation. If max{R1,R2}=R1, then the TB-VL co-infection model exhibits backward bifurcation for values of R1. Furthermore, if max{R1,R2}=R2, and by choosing the transmission probability, βL as the bifurcation parameter, then the phenomenon of backward bifurcation occurs for values of R2. Consequently, the full model, whose associated reproduction number is R0, also exhibits backward bifurcation when R0=1. The equilibrium points and their stability for the models are determined and analyzed based on the magnitude of the respective reproduction numbers. Finally, some numerical simulations are presented to show the reliability of our theoretical results.
Regulation of cleavage embryo genes upon DRP1 inhibition in mouse embryonic stem cells
Authors: Guo Shi-Meng , Zhang Yi-Ran , Ma Bing-Xin , Zhou Li-Quan , Yin Ying
Published: May 2023

Dynamic-related protein 1 (DRP1) is a key protein of mitochondrial fission. In this study, we found that inhibition of activity of DRP1 led to increased levels of cleavage embryo genes in mouse embryonic stem cells (mESCs), which might reflect a transient totipotency status derived from pluripotency. This result indicates that DRP1 inhibition in mESCs leads to a tendency to obtain a new expression profile similar to that of the 2C-like state. Meanwhile, we also noticed that the glycolysis/gluconeogenesis pathway and its related enzymes were significantly downregulated, and the key glycolytic enzymes were also downregulated in various 2C-like cells. Moreover, when DRP1 activity was inhibited from the late zygote when cleavage embryo genes started to express, development of early embryos was inhibited, and these cleavage embryo genes failed to be efficiently silenced at the late 2-cell (2C) stage. Taken together, our result shows that DRP1 plays an important role in silencing cleavage embryo genes for totipotency-to-pluripotency transition.
Eu3+ and Tb3+ coordination compounds with phenyl-containing carbacylamidophosphates: comparison with selected Ln3+ β-diketonates
Authors: Kariaka Nataliia S. , Lipa Aneta , Carneiro Neto Albano N. , Malta Oscar L. , Gawryszewska Paula , Amirkhanov Volodymyr M.
Published: May 2023

Materials based on Eu3+ and Tb3+ coordination compounds are of great interest due to their strong red and green luminescence. Appropriate selection of ligands plays a huge role in optimizing their photophysical properties. Another very helpful instrument for such optimization is theoretical modelling, which permits the prediction of the emissive properties of materials through intramolecular energy transfer analysis. The ligands that allow for achieving high efficiency of Eu3+ and Tb3+ emissions include carbacylamidophosphates (CAPh, HL). In this brief review, we summarize recent research for lanthanides CAPh-based coordination compounds of general formulas Cat[LnL]4, [LnL3Q] and [Ln(HL)3(NO3)3], where Cat+ = Cs+, NEt4+, PPh4+ and Q = 1,10-phenanthroline, 2,2-bipyridine or triphenylphosphine oxide, involving the use of thermal gravimetric analysis, X-ray analysis, and absorption and luminescence spectroscopy. We carried out a comparison with selected Ln3+ β-diketonates. Possibilities and developments of theoretical calculations on energy transfer rates are also presented.
Hallmarks of the relationship between host and Trypanosoma cruzi sulfated glycoconjugates along the course of Chagas disease
Authors: Soprano Luciana L. , Ferrero Maximiliano R. , Jacobs Thomas , Couto Alicia S. , Duschak Vilma G.
Published: May 2023

American Trypanosomiasis or Chagas disease (ChD), a major problem that is still endemic in large areas of Latin America, is caused by Trypanosoma cruzi. This agent holds a major antigen, cruzipain (Cz). Its C-terminal domain (C-T) is retained in the glycoprotein mature form and bears several post-translational modifications. Glycoproteins containing sulfated N-linked oligosaccharides have been mostly implicated in numerous specific procedures of molecular recognition. The presence of sulfated oligosaccharides was demonstrated in Cz, also in a minor abundant antigen with serine-carboxypeptidase (SCP) activity, as well as in parasite sulfatides. Sulfate-bearing glycoproteins in Trypanosomatids are targets of specific immune responses. T. cruzi chronically infected subjects mount specific humoral immune responses to sulfated Cz. Unexpectedly, in the absence of infection, mice immunized with C-T, but not with sulfate-depleted C-T, showed ultrastructural heart anomalous pathological effects. Moreover, the synthetic anionic sugar conjugate GlcNAc6SO3-BSA showed to mimic the N-glycan-linked sulfated epitope (sulfotope) humoral responses that natural Cz elicits. Furthermore, it has been reported that sulfotopes participate via the binding of sialic acid Ig-like-specific lectins (Siglecs) to sulfosialylated glycoproteins in the immunomodulation by host–parasite interaction as well as in the parasite infection process. Strikingly, recent evidence involved Cz-sulfotope-specific antibodies in the immunopathogenesis and infection processes during the experimental ChD. Remarkably, sera from chronically T. cruzi-infected individuals with mild disease displayed higher levels of IgG2 antibodies specific for sulfated glycoproteins and sulfatides than those with more severe forms of the disease, evidencing that T. cruzi sulfotopes are antigenic independently of the sulfated glycoconjugate type. Ongoing assays indicate that antibodies specific for sulfotopes might be considered biomarkers of human cardiac ChD progression, playing a role as predictors of stability from the early mild stages of chronic ChD.
Mmu-miR-25-3p promotes macrophage autophagy by targeting DUSP10 to reduce mycobacteria survival
Authors: Yuan Wenqi , Zhan Xuehua , Liu Wei , Ma Rong , Zhou Yueyong , Xu Guangxian , Ge Zhaohui
Published: May 2023

Background

The present study aimed to investigate the regulation of miR-25-3p on macrophage autophagy and its effect on macrophage clearance of intracellular Mycobacterium bovis Bacillus Calmette-Guerin (BCG) retention based on the previous findings on the differential expression of exosomal miRNA in macrophages infected with BCG.

Methods

Through enrichment analysis and Hub gene analysis, key differentially expressed miRNA and its target genes were selected. The targeted binding ability of the screened mmu-miR-25-3p and its predicted target gene DUSP10 was determined through the TargetScan database, and this was further verified by dual luciferase reporter gene assay. mmu-miR-25-3p mimics, mmu-miR-25-3p inhibitor, si-DUSP10, miR-NC,si-NC and PD98059 (ERK Inhibitor) were used to intervene macrophages Raw264.7. Rt-qPCR was used to detect the expression levels of mmu-miR-25-3p and DUSP10 mRNA. Western blot was used to detect the expression levels of DUSP10, LC3-II, p-ERK1/2, beclin1, Atg5 and Atg7. The autophagy flux of macrophage Raw264.7 in each group was observed by confocal laser microscopy, and the expression distribution of DUSP10 and the structure of autophagosomes were observed by transmission electron microscopy. Finally, the intracellular BCG load of macrophage Raw264.7 was evaluated by colony-forming unit (CFU) assay.

Results

Bioinformatics analysis filtered and identified the differentially expressed exosomal miRNAs. As a result, mmu-miR-25-3p expression was significantly increased, and dual specificity phosphatase 10 (DUSP10) was predicted as its target gene that was predominantly involved in autophagy regulation. The dual luciferase reporter gene activity assay showed that mmu-miR-25-3p was targeted to the 3’-untranslated region (UTR) of DUSP10. The infection of BCG induced the upregulation of mmu-miR-25-3p and downregulation of DUSP10 in RAW264.7 cells, which further increased the expression of LC3-II and promoted autophagy. Upregulated mmu-miR-25-3p expression decreased the level of DUSP10 and enhanced the phosphorylation of ERK1/2, which in turn upregulated the expression of LC3-II, Atg5, Atg7, and Beclin1. Immuno-electron microscopy, transmission electron microscopy, and autophagic flux analysis further confirmed that the upregulation of mmu-miR-25-3p promotes the autophagy of macrophages after BCG infection. The CFU number indicated that upregulated mmu-miR-25-3p expression decreased the mycobacterial load and accelerated residual mycobacteria clearance.

Conclusion

mmu-miR-25-3p promotes the phosphorylation of ERK1/2 by inhibiting the expression of DUSP10, thus enhancing the BCG-induced autophagy of macrophages. These phenomena reduce the bacterial load of intracellular Mycobacterium and facilitate the clearance of residual mycobacteria. mmu-miR-25-3p has great potential as a target for anti-tuberculosis immunotherapy and can be the optimal miRNA loaded into exosomal drug delivery system in future studies.
Comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication: a network meta-analysis
Authors: Wang Yue , Wang Xue , Cao Xue-Yan , Zhu Han-Long , Miao Lin
Published: May 2023

Background

Probiotics has been reported as an effective supplement for Helicobacter pylori eradication. However, knowledge of their comparative efficacy is still lacking.

Aim

In this study, we used network meta-analysis of current probiotics supplement used in standard triple therapy to assess and rank their comparative effectiveness.

Methods

All randomized controlled trials from three main databases (PubMed, Embase and Cochrane Library) up to April 2022 were collected and filtered to meet our criterion. We used Bayesian network meta-analysis to evaluate the eligible randomized controlled trials and gave a rank for the efficiency and incidence of side effects of each probiotics supplement. The ranking probability for each therapy was assessed by means of surfaces under cumulative ranking values. Subgroup analysis was conducted to evaluate other possible influencing factors.

Results

34 eligible randomized controlled trials entered the following meta-analysis, including 9,004 patients randomized to 10 kinds of therapies. Result showed that most probiotics added therapies had better outcomes than triple therapy, among which Bifidobacterium-Lactobacillus and Bifidobacterium-Lactobacillus-Saccharomyces adjuvant therapy could obtain comprehensive benefit with high eradication rate (78.3% and 88.2% respectively), and cause few side effects. Combination of different probiotics, adding probiotics before or after triple therapy and longer duration of probiotics can improve therapeutic effect in H.pylori infected individuals.

Conclusion

For triple therapy of H.pylori infection, adding probiotics can increase eradication rate and bring protective effect. Considering the overall influence, Bifidobacterium-Lactobacillus or Bifidobacterium-Lactobacillus-Saccharomyces therapy can be a better choice in improving H.pylori eradication process.
Roles of inflammasomes in viral myocarditis
Authors: Xu Jingyu , Zhou Zihao , Zheng Yidan , Yang Sai , Huang Kun , Li Huili
Published: May 2023

Viral myocarditis (VMC), characterized by viral infection-induced inflammation, is a life-threatening disease associated with dilated cardiomyopathy or heart failure. Innate immunity plays a crucial role in the progression of inflammation, in which inflammasomes provide a platform for the secretion of cytokines and mediate pyroptosis. Inflammasomes are rising stars gaining increasing attention. The nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome, the caspase recruitment domain-containing protein 8 (CARD8) inflammasome, and the caspase-11 inflammasome are three inflammasomes that were reported to affect the process and prognosis of VMC. These inflammasomes can be activated by a wide range of cellular events. Accumulating evidence has suggested that inflammasomes are involved in different stages of VMC, including the trigger and progression of myocardial injury and remodeling after infection. In this review, we summarized the pathways involving inflammasomes in VMC and discussed the potential therapies targeting inflammasomes and related pathways.