bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Urine Albumin/Creatinine Ratio below 30 mg/g and Left Ventricular Hypertrophy in Patients with Type 2 Diabetes
Authors: Xie Xiangkun , Peng Zhengliang , Li Hanlin , Li Dan , Tu Yan , Bai Yujia , Huang Xingfu , Lai Wenyan , Zhan Qiong , Zeng Qingchun , Xu Dingli
Published: January 2020

Several studies show that even a level of urine albumin/creatinine ratio (UACR) within the normal range (below 30 mg/g) increases the risk of cardiovascular diseases. We speculate that mildly increased UACR is related to left ventricular hypertrophy (LVH) in patients with type 2 diabetes mellitus (T2DM). In this retrospective study, 317 patients with diabetes with normal UACR, of whom 62 had LVH, were included. The associations between UACR and laboratory indicators, as well as LVH, were examined using multivariate linear regression and logistic regression, respectively. The diagnostic efficiency and the optimal cutoff point of UACR for LVH were evaluated using the area under the receiver operating characteristic curve (AUC) and Youden index. Our results showed that patients with LVH had significantly higher UACR than those without LVH (P < 0.001). The prevalence of LVH presented an upward trend with the elevation of UACR. UACR was independently and positively associated with hemoglobin A1c (P < 0.001). UACR can differentiate LVH (AUC = 0.682, 95% CI (0.602–0.760), P < 0.001). The optimal cutoff point determined with the Youden index was UACR = 10.2 mg/g. When categorized by this cutoff point, the odds ratio (OR) for LVH in patients in the higher UACR group (10.2–30 mg/g) was 3.104 (95% CI: 1.557–6.188, P = 0.001) compared with patients in the lower UACR group (<10.2 mg/g). When UACR was analyzed as a continuous variable, every double of increased UACR, the OR for LVH was 1.511 (95% CI: 1.047–2.180, P = 0.028). Overall, UACR below 30 mg/g is associated with LVH in patients with T2DM. The optimal cutoff value of UACR for identifying LVH in diabetes is 10 mg/g.
The Evaluation of the Antioxidant and Intestinal Protective Effects of Baicalin-Copper in Deoxynivalenol-Challenged Piglets
Authors: Zha Andong , Yuan Daixiu , Cui Zhijuan , Qi Ming , Liao Simeng , Liao Peng , Tan Bie
Published: January 2020

The present study was performed to evaluate the antioxidant and intestinal protective effects of baicalin-copper on deoxynivalenol-challenged piglets. Forty weaned piglets were randomly divided into four groups and assigned to different diets: (1) basal diet (Con), (2) 4 mg/kg deoxynivalenol of basal diet (DON), (3) 5 g/kg baicalin-copper of basal diet (BCU); and (4)4 mg/kg deoxynivalenol+5 g/kg baicalin‐copperof basal diet (DBCU). The results showed that the ADFI and ADG of piglets in the DON group were markedly lower than those in the Con group, but the ADFI and ADG of the DBCU group were not significantly different from those of the Con group. In piglets fed a DON-contaminated diet, dietary supplementation with BCU significantly decreased the mRNA levels of P70S6K, 4E-BP1, and HSP70 in the liver, the protein expression of HO-1 in the jejunum, and the expression of p-Nrf2 and p-NF-κB in the ileum but increased Mn-SOD activity in serum. Dietary supplementation with BCU increased jejunal maltase, ZIP4 and MT mRNA levels, and serum concentrations of Arg, Val, Ile, Leu, Lys, and Tyr in DON-contaminated piglets. In summary, BCU can alleviate the growth impairment induced by DON and enhance antioxidant capacity and nutrition absorption in piglets fed DON-contaminated diets.
[Retracted] Outcome of Gynecologic Laparoendoscopic Single‐Site Surgery with a Homemade Device and Conventional Laparoscopic Instruments in a Chinese Teaching Hospital
Authors: Su Xianghui , Jin Xiaolong , Wen Canliang , Xu Qiong , Cai Chunfang , Zhong Zhuohui , Tang Xiang
Published: January 2020

Objective. To demonstrate various benign gynecologic diseases that can be performed by laparoendoscopic single‐site surgery (LESS) with conventional laparoscopic instruments. Method. Patients with benign gynecologic diseases that need ovarian cystectomy, fallopian tube resection, or myomectomy were divided into experimental group and control group, and perioperative outcomes of these patients were analyzed. Results. From November 2017 to May 2018, 65 LESS gynecological surgeries were performed, among which there were 25 ovarian cystectomies, 28 unilateral fallopian tube resections, and 12 myomectomies. All the surgeries were completed smoothly, and only one surgery needed one more additional port. No patients have severe complications. Operative time, intraoperative blood loss, and perioperative complications have no difference between the two groups. The LESS laparoscopy group had less postoperative pain scores and longer bowel recovering time, compared with the conventional laparoscopy group (<0.05). Conclusion. Compared with traditional laparoscopy, LESS surgery with conventional laparoscopic instruments is feasible and safe, but postoperative exhaust time is longer than the control group.
Comparison of Biomechanical Performance of Five Different Treatment Approaches for Fixing Posterior Pelvic Ring Injury
Authors: Lu Yongtao , He Yiqian , Li Weiteng , Yang Zhuoyue , Peng Ruifei , Yu Li
Published: January 2020

Background. A large number of pelvic injuries are seriously unstable, with mortality rates reaching 19%. Approximately 60% of pelvic injuries are related to the posterior pelvic ring. However, the selection of a fixation method for a posterior pelvic ring injury remains a challenging problem for orthopedic surgeons. The aim of the present study is to investigate the biomechanical performance of five different fixation approaches for posterior pelvic ring injury and thus provide guidance on the choice of treatment approach in a clinical setting. Methods. A finite element (FE) model, including the L3-L5 lumbar vertebrae, sacrum, and full pelvis, was created from CT images of a healthy adult. Tile B and Tile C types of pelvic fractures were created in the model. Five different fixation methods for fixing the posterior ring injury (PRI) were simulated: TA1 (conservative treatment), TA2 (S1 screw fixation), TA3 (S1 + S2 screw fixation), TA4 (plate fixation), and TA5 (modified triangular osteosynthesis). Based on the fixation status (fixed or nonfixed) of the anterior ring and the fixation method for PRI, 20 different FE models were created. An upright standing loading scenario was simulated, and the resultant displacements at the sacroiliac joint were compared between different models. Results. When TA5 was applied, the resultant displacements at the sacroiliac joint were the smallest (1.5 mm, 1.6 mm, 1.6 mm, and 1.7 mm) for all the injury cases. The displacements induced by TA3 and TA2 were similar to those induced by TA5. TA4 led to larger displacements at the sacroiliac joint (2.3 mm, 2.4 mm, 4.8 mm, and 4.9 mm), and TA1 was the worst case (3.1 mm, 3.2 mm, 6.3 mm, and 6.5 mm). Conclusions. The best internal fixation method for PRI is the triangular osteosynthesis approach (TA5), followed by S1 + S2 screw fixation (TA3), S1 screw fixation (TA2), and plate fixation (TA4).
Enterotype Bacteroides Is Associated with a High Risk in Patients with Diabetes: A Pilot Study
Authors: Wang Jiajia , Li Wenjuan , Wang Chuan , Wang Lingshu , He Tianyi , Hu Huiqing , Song Jia , Cui Chen , Qiao Jingting , Qing Li , Li Lili , Zang Nan , Wang Kewei , Wu Chuanlong , Qi Lin , Ma Aixia , Zheng Huizhen , Hou Xinguo , Liu Fuqiang , Chen Li
Published: January 2020

Background. More and more studies focus on the relationship between the gastrointestinal microbiome and type 2 diabetes, but few of them have actually explored the relationship between enterotypes and type 2 diabetes. Materials and Methods. We enrolled 134 patients with type 2 diabetes and 37 nondiabetic controls. The anthropometric and clinical indices of each subject were measured. Fecal samples of each subject were also collected and were processed for 16S rDNA sequencing. Multiple logistic regression analysis was used to determine the associations of enterotypes with type 2 diabetes. Multiple linear regression analysis was used to explore the relationship between lipopolysaccharide levels and insulin sensitivity after adjusting for age, BMI, TG, HDL-C, DAO, and TNF-α. The correlation analysis between factors and microbiota was identified using Spearman correlation analysis. The correlation analysis between factors was identified using partial correlation analysis. Results. Gut microbiota in type 2 diabetes group exhibited lower bacterial diversity compared with nondiabetic controls. The fecal communities from all subjects clustered into two enterotypes distinguished by the levels of Bacteroides and Prevotella. Logistic regression analysis showed that the Bacteroides enterotype was an independent risk factor for type 2 diabetes by decreasing insulin sensitivity. The levels of lipopolysaccharide and tumor necrosis factor-alpha were higher in the Bacteroides enterotype compared to the Prevotella enterotype. Partial correlation analysis showed that lipopolysaccharide was closely associated with diamine oxidase, tumor necrosis factor-alpha, and Gutt insulin sensitivity index after adjusting for multiple covariates. Furthermore, the level of lipopolysaccharide was found to be an independent risk factor for insulin sensitivity. Conclusions. We identified two enterotypes, Bacteroides and Prevotella, among all subjects. Our results showed that the Bacteroides enterotype was an independent risk factor for type 2 diabetes, which was due to increased levels of lipopolysaccharide causing decreased insulin sensitivity.
Paraquat Exposure Induces Pulmonary Cell Mitophagy by Enhancing the PINK1/Parkin Signaling
Authors: Liu Kaixiang , Zhan Zhipeng , Gao Wei , Feng Jie , Xie Xisheng
Published: January 2020

Paraquat (PQ) poisoning can cause oxidative stress, acute lung injury (ALI), and fibrosis. Excess oxidative stress can induce mitophagy. However, whether PQ exposure can induce mitophagy, contributing to the development of ALI and pulmonary fibrosis in vivo has not been clarified. Here, we show that PQ exposure induces ALI and fiber accumulation in the lung of rats in a time‐dependent manner, accompanied by upregulating fibronectin (FN) and Collagen I (COL‐I) expression. PQ exposure increased mitophagosome formation and PINK1 and Parkin expression in the lungs of rats. Similarly, PQ exposure reduced the viability and mitochondrial membrane potential, but enhanced FN, COL‐I, PINK1, and Parkin expression in A549 cells. In contrast, PINK1 silencing significantly mitigated the PQ‐upregulated Parkin, FN, and COL‐I expression in A549 cells. Hence, PQ exposure induced ALI and fibrosis in rats by enhancing the PINK1/Parkin signaling and profibrotic factor expression in the lungs. Therefore, our findings suggest that the PINK1/Parkin signaling may be new therapeutic targets and may provide new insights in the pathogenesis of PQ‐related ALI in rats.
An Interval Efficiency Measurement without Sign Restrictions in Data
Authors: Yang Liyang , Mo Renbian
Published: January 2020

Mostly, all conventional DEA models assume that input-output data are precise and nonnegative, but in real-life application, this condition is mostly not applicable. Through progressive development in the methodology of DEA, some models separately deal with imprecise and negative data. In this study, the IMSBM model is proposed to evaluate the performance of a set of homogenous DMUs with imprecise and negative input-output data. The IMSBM model is far superior to models with similar capability because it considers the inefficiency caused by both radial and nonradial slacks. The lower and upper bounds of interval efficiency calculated by the IMSBM model reflect the performance of observed DMU in most unfavourable and most favourable situations. Further, it is proved that the IMSBM model is units invariant, monotone, and translation invariant. Moreover, we elaborate both bounds of the interval efficiency are in the range of [0,1]. The degree of preference approach is introduced to rank the DMUs. In addition, we compare the interval efficiency scores calculated by the IMSBM model and the interval SORM model and explain the reason for the difference between the scores. By adjusting the weights of inputs and outputs, it is found that only inefficiency scores fluctuate with slack weights.
Continuous Adsorption Modeling and Fixed Bed Column Studies: Adsorption of Tannery Wastewater Pollutants Using Beach Sand
Authors: El Mouhri Ghita , Merzouki Mohammed , Belhassan Hajar , Miyah Youssef , Amakdouf Halima , Elmountassir Rabea , Lahrichi Anissa
Published: January 2020

This study deals with the removal of residual pollutants from tanning wastewater by continuous adsorption mechanism, using local sand as a low-cost adsorbent. The possibility of pretreating a complex tannery effluent heavily loaded with a natural material such as sand is significant. The characterization of the adsorbent before and after continuous adsorption was performed by X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy. Column studies were also carried out to evaluate the performance of the adsorbent and the efficiency of column adsorption. The adsorption kinetic rate seems to be strongly influenced by certain parameters such as the particle size of the material used, the withdrawal rate of the influent and the height of the adsorbent bed, and optimized parameters were found to be 63 μm, 15 ml·min−1, and 7 cm, respectively, and the color removal has achieved maximum values which vary between 95 and 100%. The results suggest that sand can be used as an economical adsorbent for the removal of color from the wastewater of the tanning industries.
Comparative Study on the Elucidation of Sedimentary Phosphorus Species Using Two Methods, the SMT and SEDEX Methods
Authors: Loh Pei Sun , Ying Chen-Yu , Alnoor Hussien Ibrahim Mohammed , Huang Xing-Rui , Lou Zhang-Hua , Chen Xue-Gang , He Shuangyan , Jiang Zong-Pei , Jin Ai-Min
Published: January 2020

Sedimentary phosphorus (P) forms are important representatives of P sources and their bioavailability as well as the potential of sediments to release P in water. In this study, surface sediments along a transect of the Changjiang Estuary and two transects along the Andong salt marsh in the southwest of Hangzhou Bay were subjected to the elucidation of sedimentary P species using the standards, measurements, and testing (SMT) and sequential extraction (SEDEX) methods. The results showed that the mean sedimentary P forms elucidated by the SMT method were as follows: organic P (OP; ∼11–14 mg/kg; ∼30–45% of total P; TP) > apatite P (∼5–15 mg/kg; ∼21–36% TP) > Fe/Al-P (∼8–14 mg/kg; ∼31–34% TP), with inorganic P (IP) composing 54–70% of TP. The mean sedimentary P forms elucidated by the SEDEX method were as follows: authigenic P (∼54–68 mg/kg; ∼41–46% TP) > extractable P (Ex-P; ∼36–53 mg/kg; ∼28–34%) > Fe-P (∼21–27 mg/kg; ∼13–19%) > OP (∼8.7–13 mg/kg; ∼5–8%) > detrital P (De-P; ∼2 mg/kg; ∼1–2% TP), with IP composed of ∼91–94% TP. These results showed that the SEDEX method elucidated higher concentrations of sedimentary P forms as well as the TP from these coastal sediments although the SMT method had the advantage of being more economic and faster. The results of both the SMT and SEDEX methods showed that the Andong salt marsh and Changjiang Estuary sediments had much bioavailable P. The mean percentages of bioavailable P from the SMT and SEDEX methods were ∼64–74% and 52–56% of TP, respectively, indicating that these sediments were prone to release P to the coastal areas.
Moving Load Spectrum for Analyzing the Extreme Response of Bridge Free Vibration
Authors: Li Jinhua , Zhang Huantao
Published: January 2020

In order to more effectively establish the relationship between moving load speed and the extreme response of bridge free vibration, a novel analysis method is presented based on the moving load spectrum, which is deduced from Fourier transform in this paper. By analyzing the moving load spectrum in detail, the moving load velocities which lead to the extreme responses of bridge free vibration under single moving constant force or harmonic force are obtained, and the corresponding formula for calculating the moving load velocity which leads to the maximum response of bridge free vibration is put forward. Finally, the moving load spectrum for analyzing the extreme response of bridge free vibration is validated by a large number of calculations in the time domain in this paper. The results show that the moving velocities corresponding to the extreme points in the moving load spectrum are consistent with the velocities corresponding to the extreme points of the bridge vibration response obtained in the time domain, and the forced and free vibration displacement responses of bridge are not the largest when the single moving constant force or harmonic force passes through the bridge at the resonant velocity compared to other speeds.
Predicting Therapeutic Antibody Delivery into Human Head and Neck Cancers
Authors: Lu Guolan , Fakurnejad Shayan , Martin Brock A. , van den Berg Nynke S. , van Keulen Stan , Nishio Naoki , Zhu Ashley J. , Chirita Stefania U. , Zhou Quan , Gao Rebecca W. , Kong Christina S. , Fischbein Nancy , Penta Mrudula , Colevas Alexander D. , Rosenthal Eben L.
Published: January 2020

Purpose:

The efficacy of antibody-based therapeutics depends on successful drug delivery into solid tumors; therefore, there is a clinical need to measure intratumoral antibody distribution. This study aims to develop and validate an imaging and computation platform to directly quantify and predict antibody delivery into human head and neck cancers in a clinical study.

Experimental Design:

Twenty-four patients received systemic infusion of a near-infrared fluorescence-labeled therapeutic antibody followed by surgical tumor resection. A computational platform was developed to quantify the extent of heterogeneity of intratumoral antibody distribution. Both univariate and multivariate regression analyses were used to select the most predictive tumor biological factors for antibody delivery. Quantitative image features from the pretreatment MRI were extracted and correlated with fluorescence imaging of antibody delivery.

Results:

This study not only confirmed heterogeneous intratumoral antibody distribution in-line with many preclinical reports, but also quantified the extent of interpatient, intertumor, and intratumor heterogeneity of antibody delivery. This study demonstrated the strong predictive value of tumor size for intratumoral antibody accumulation and its significant impact on antibody distribution in both primary tumor and lymph node metastasis. Furthermore, this study established the feasibility of using contrast-enhanced MRI to predict antibody delivery.

Conclusions:

This study provides a clinically translatable platform to measure antibody delivery into solid tumors and yields valuable insight into clinically relevant antibody tumor penetration, with implications in the selection of patients amenable to antibody therapy and the design of more effective dosing strategies.
Efficacy of Long-Term Feeding of α-Glycerophosphocholine for Aging-Related Phenomena in Old Mice
Authors: Narukawa Masataka , Kamiyoshihara Aya , Izu Hanae , Fujii Tsutomu , Matsubara Kiminori , Misaka Takumi
Published: January 2020

α-Glycerophosphocholine (GPC) is a natural source of choline. It reportedly prevents aging-related decline in cognitive function, but the underlying mechanism remains unclear. Although it is understood that aging influences taste sensitivity and energy regulation, whether GPC exerts antiaging effects on such phenomena requires further elucidation. Here, we used old C57BL/6J mice that were fed a GPC-containing diet, to investigate the molecular mechanisms underlying the prevention of a decline in cognitive function associated with aging and examine the beneficial effects of GPC intake on aging-related phenomena, such as taste sensitivity and energy regulation. We confirmed that GPC intake reduces the aging-related decline in the expression levels of genes related to long-term potentiation. Although we did not observe an improvement in aging-related decline in taste sensitivity, there was a notable improvement in the expression levels of β-oxidation-associated genes in old mice. Our results suggest that the prevention of aging-related decline in cognitive function by GPC intake may be associated with the improvement of gene expression levels of long-term potentiation. Furthermore, GPC intake may positively influence lipid metabolism.
Symptoms of Primary Hyperparathyroidism in Men and Women: The Same but Different?
Authors: Weber Theresia , Hillenbrand Andreas , Peth Simon , Hummel Rainer
Published: January 2020

Introduction and Objective: Typical symptoms for primary hyperparathyroidism (pHPT) include osteoporosis, bone or joint pain, and nephrolithiasis, as well as fatigue, depression, gastritis, and cardiovascular disease. The female:male ratio was 3:1. The aim of this retrospective study was to evaluate the possible influence of gender-specific aspects of these symptoms. Methods: From February 2018 to November 2019, parathyroid surgery was performed in 125 patients with pHPT (age: 23–83 years); 95 (76%) were female, and 30 (24%) were male. Preoperatively, a standardized medical history including 7 typical symptoms of pHPT was used for routine clinical documentation according to the StuDoQ Thyroid and Parathyroid Registry. Results: For both groups (mean age: 60.4 years for females and 60.2 years for males), no sex differences were found in serum calcium or parathyroid hormone levels. For females, there was a tendency towards smaller hyperfunctioning parathyroid glands (16.8 vs. 20.5 mm) with less weight (1.14 vs. 1.52 g) and multiglandular disease. Nephrolithiasis was significantly more frequent in men than in women (36.7 vs. 16.8%, respectively; p = 0.036), but the difference in hypertension was not significant (60% in men vs. 47.4% in women, p = 0.230). Women reported significantly more often bone and joint pain (44.2% in women vs. 20% in men, p = 0.053) and depressive episodes (32.6% in women vs. 10% in men, p = 0.016). Conclusion: 91.2% of patients transferred for parathyroidectomy described typical symptoms of pHPT. However, an unexpected high gender difference was found following the analysis of symptoms documented in the StuDoQ Registry.
Design Process
Authors: Barcellos Ekaterina Emmanuil Inglesis , Botura Junior Galdenoro
Published: January 2020

Design é um processo criativo e inovador que recorre ao conhecimento técnico da engenharia para obter o suporte necessário para o desenvolvimento de um universo de produtos, serviços e benefícios voltados à sociedade caracterizada pelo consumo. Como forma de potencializar a inovação uma maior aproximação entre o Design e a engenharia demonstra ser uma das possíveis estratégias adequadas. Na busca pela otimização do processo e do produto, inovação, benchmarking e melhores resultados para os usuários e suas necessidades deve-se recorrer a uma metodologia de projeto. Este tipo de metodologia é denominado “Design Process”. O processo do projeto técnico e criativo possui raízes oriundas da engenharia e inerentes ao Design. Consiste em adaptar métodos de concepção e desenvolvimento usuais para ambas as áreas, onde igualmente se trabalha o projeto em etapas, envolvendo o conceito de ergonomia organizacional, da fase de criação até o produto final. Este artigo propõe uma breve análise sobre as metodologias do “Design Process”, buscando elucidar os pontos tangentes nos processos do Design e da Engenharia, demonstrando que a aproximação entre estas áreas pode melhorar o desempenho do projeto de produtos e serviços. Ao identificar esta orientação comum, o estudo demostrou que a parceria otimiza resultados, com potencial para a melhoria na geração da inovação.
Scan-to-HBIM aplicado à igreja da Pampulha de Oscar Niemeyer
Authors: Cogima Camila Kimi , Nascimento Rodrigo Vinicius De Carvalho , De Paiva Pedro Victor Vieira , Carvalho Marco Antonio Garcia de , Dezen-Kempter Eloisa
Published: January 2020

Este artigo relata a aplicação de técnicas de varredura digital 3D e Modelagem da Informação da Construção (BIM) para a preservação do patrimônio histórico. Na última década difundiu-se uma nova perspectiva de aplicação da tecnologia BIM para a documentação e gestão do patrimônio histórico, o denominado HBIM, que apesar da relevância para a interpretação e caracterização do estado de conservação do objeto histórico, ainda não alcançou o mesmo impacto que a modelagem inteligente aplicada a edificações novas. O artigo foca na criação de um modelo digital inteligente para uma obra singular da arquitetura moderna brasileira, a Igreja de São Francisco de Assis, na lagoa da Pampulha, a partir da utilização de duas técnicas de varredura digital. O modelo de nuvem de pontos obtido por dois sistemas de varredura (fotogrametria aérea e escaneamento a laser) fornece uma descrição detalhada da complexidade e irregularidade geométrica do edifício e é a base do modelo paramétrico preciso criado com ferramentas BIM. Neste artigo são abordados o manuseio de dois programas de processamento de dados, gerados pelos sensores, e os processos de manipulação da nuvem de pontos para otimizar a modelagem das formas complexas da igreja. São comparados o aspecto visual, os formatos de importação e exportação e o índice de sobreposição das nuvens de pontos. Este estudo demonstrou o potencial do levantamento digital, incluindo sensores de baixo custo, e o HBIM para a documentação e valorização do patrimônio construído.
Reatividade cutânea a alérgenos alimentares em habitantes da cidade de São Paulo
Authors: Silva Débora Da , Nakamatsu Bernardo Yassunobu , Fernandes Archangelo Padreca , Victor Jefferson Russo
Published: January 2020

Fundamentos: As reações alérgicas contra proteínas alimentares constituem um problema de saúde pública que tem se agravado em todo o mundo. Este tipo de reação afeta a qualidade de vida e seu tratamento implica em altos custos. Objetivos: Neste trabalho, objetivamos identificar o padrão de reatividade alérgica cutânea de indivíduos voluntários residentes na cidade de São Paulo e identificar fatores sociodemográficos que possam ter relação com este tipo de alergia. Metodologia: 35 voluntários foram submetidos ao teste cutâneo de puntura (TCP) e a um questionário sócio demográfico. Foi testada a reatividade cutânea contra alérgenos do leite, ovos, castanha, amendoim, camarão e carne suína. Principais resultados: Foi possível constatar que o alérgeno que apresentou maior frequência de reatividade foi o camarão seguido por carne suína, leite, ovo, castanha do Pará e amendoim.  Além disso, constatamos que geralmente os voluntários apresentam reatividade a apenas um alérgeno e que não tem conhecimento sobre seu potencial para desenvolver alergias alimentares. Por fim, ainda observamos que a quantidade de animais domésticos pode estar relacionada ao potencial alérgico individual. Conclusões: Em conclusão, foi possível atualizar a descrição do perfil de reatividade alérgica alimentar em indivíduos residentes na cidade de São Paulo e sugerir uma inédita relação com a quantidade de animais domésticos.
Insuficiência hepática aguda como apresentação de linfoma não-Hodgkin
Authors: Jesus Gustavo Nobre De , Anselmo Mónica Palma , Gonçalves Inês , Quadros Catarina , Lopes João Madeira , Meneses João , Victorino Rui Maria Manoel
Published: January 2020

A Insuficiência Hepática Aguda (IHA) consiste no aparecimento súbito de coagulopatia e encefalopatia hepática em doente sem doença hepática prévia. Embora o fígado seja afectado por metastização, a IHA costuma ser incomum e surgir apenas nos estadios terminais da doença. Apesar de a IHA ser uma forma rara de apresentação de neoplasias, tem sido observada em neoplasias hematológicas, nomeadamente na doença de Hodgkin e linfoma não-Hodgkin difuso de grandes células, B especialmente em doentes imunossuprimidos. É relatado um caso de um doente de 39 anos, vírus da imunodeficiência humana (VIH) 1 postivo, cuja manifestação inaugural de um linfoma não-Hodgkin foi IHA.
Doença de Madelung (lipomatose simétrica múltipla)
Authors: Guariento Karina Nacano , Gomes Rafael Tomaz , Esteves Vivien Longo , Nai Gisele Alborghetti , Abreu Marilda Aparecida Milanêz Morgado De
Published: January 2020

Modelo do estudo: O presente estudo é um relato de caso, realizado a partir de revisão de prontuário, autorizado pelo comitê de ética do hospital, e o termo de consentimento livre e esclarecido assinado pelo paciente.

Importância do problema: A doença de Madelung ou lipomatose simétrica múltipla é uma desordem rara, de etiologia indefinida, associado frequentemente ao alcoolismo e caracterizada pela presença de massas de tecido adiposo, não encapsuladas, distribuídas simetricamente, principalmente nas regiões superiores do tronco e cervical, que aumentam progressivamente de tamanho e levam a desfiguração cosmética do paciente. Pode provocar sintomas derivados de compressão de estruturas vasculares, nervosas e do trato aerodigestivo. A lipectomia e lipoaspiração são os tratamentos de escolha, embora geralmente paliativo.

Comentários: O presente trabalho relata um caso da doença de Madelung e apresenta uma breve revisão da literatura sobre o tema, ressaltando-se a importância do reconhecimento clínico desta entidade, bem como o seu manejo multidisciplinar.
As vozes do corpo
Authors: Gómez Yoanky Cordero
Published: January 2020

Dois poemas que falam da relação palavra-corpo. Da função da palavra como vehículo de expressão.
Iniciando a eternidade: história e mito em El Evangelio según San Marcos, de Jorge Luis Borges
Authors: Daie Fábio Salem
Published: January 2020

O presente artigo analisa o conto El Evangelio Según San Marcos, do escritor argentino Jorge Luis Borges, buscando localizar em sua estrutura alguns dos sentidos possíveis impressos pelo escritor ao processo de modernização portenho. Desse modo, uma leitura a contrapelo não somente do significado das “margens” do tecido urbano, senão igualmente do “mito” em oposição ao movimento histórico, constitui, a nosso ver, a chave de entendimento para a realização de um projeto estético que é, também, um projeto de decifração de uma realidade cindida na periferia latino-americana.
Is Anatomical Variations a Risk Factor for Cerebral Vasospasm in Anterior Communicating Complex Aneurysms Rupture?
Authors: Jacquens Alice , Shotar Eimad , Bombled Camille , Glémain Benjamin , Sourour Nader-Antoine , Nouet Aurélien , Premat Kevin , Lenck Stephanie , Degos Vincent , Clarençon Frédéric
Published: January 2020

Background and Purpose—

One-third of ruptured aneurysms are located on the anterior communicating complex with high prevalence of anatomic variations of this arterial segment. In this study, we hypothesized that anatomic variations of the anterior communicating complex increase the risk of angiographic vasospasm.

Methods—

Retrospective study of prospectively collected data from a monocentric subarachnoid hemorrhage cohort of patients admitted to neurointensive care between 2002 and 2018. Univariate followed by multivariate logistic regression analysis was used to identify factors associated with angiographic vasospasm.

Results—

One thousand three hundred seventy-four patients with aneurismal subarachnoid hemorrhage were admitted to our institution; 29.8% (n=410) were related to an anterior communicating complex aneurysm rupture; 9.2% (n=38) of them showed an anterior communicating artery variation. Angiographic vasospasm was diagnosed in 55.6% of this subgroup (vs 28.1%,
P
=0.003). In the multivariate analysis, external ventricular drain (2.2 [1.32–3.65],
P
=0.003) and anterior communicating artery variation (2.40 [1.2–4.9],
P
=0.04) were independently and significantly associated with angiographic vasospasm, while age above 60 years (0.3 [0.2–0.7];
P
=0.002) was a protective factor. However, anterior communicating artery variation was not statistically associated with ischemic vasospasm or poor neurological outcome after anterior communicating artery aneurysm rupture.

Conclusions—

Anatomic variation of anterior communicating artery could be a new biomarker to identify patients at risk to develop angiographic vasospasm post-subarachnoid hemorrhage. External validation cohorts are necessary to confirm these results.
Capture by Context Elements, Not Attentional Suppression of Distractors, Explains the PD with Small Search Displays
Authors: Kerzel Dirk , Burra Nicolas
Published: January 2020

Top–down control of attention allows us to resist attentional capture by salient stimuli that are irrelevant to our current goals. Recently, it was proposed that attentional suppression of salient distractors contributes to top–down control by biasing attention away from the distractor. With small search displays, attentional suppression of salient distractors may even result in reduced RTs on distractor-present trials. In support of attentional suppression, electrophysiological measures revealed a positivity between 200 and 300 msec contralateral to the distractor, which has been referred to as distractor positivity (PD). We reexamined distractor benefits with small search displays and found that the positivity to the distractor was followed by a negativity to the distractor. The negativity, referred to as N2pc, is considered an index of attentional selection of the contralateral element. Thus, attentional suppression of the distractor (PD) preceded attentional capture (N2pc) by the distractor, which is at odds with the idea that attentional suppression avoids attentional capture by the distractor. Instead, we suggest that the initial “PD” is not a positivity to the distractor but rather a negativity (N2pc) to the contralateral context element, suggesting that, initially, the context captured attention. Subsequently, the distractor was selected because, paradoxically, participants searched all lateral target positions (even when irrelevant) before they examined the vertical positions. Consistent with this idea, search times were shorter for lateral than vertical targets. In summary, the early voltage difference in small search displays is unrelated to distractor suppression but may reflect capture by the context.
Revisions in Utilization-Adjusted TFP and Robust Identification of News Shocks
Authors: Kurmann André , Sims Eric
Published: January 2020

This paper documents large revisions in a widely used series of utilization-adjusted total factor productivity (TFP) by Fernald (2014) and shows that these revisions can materially affect empirical results about the effects of news shocks. We trace these revisions to changes in estimated factor utilization that are evocative of cyclical measurement issues with productivity. We propose an alternative identification that is robust to these measurement issues. Applied to U.S. data, the shock predicts delayed productivity growth while simultaneously generating strong responses of novel indicators of technological innovation and forward-looking variables. The shock does not lead to comovement in macroeconomic aggregates.
Standing at the Edge of Reconstructable Transmission-History: Signs of a Secondary Sabbath-Oriented Stratum in Genesis 1:1-2:3
Authors: Carr David M.
Published: January 2020

Past studies of the formation of Genesis 1 have varied between a hypothesis of ‘Word’ and ‘Act’ Strata, the idea of a secondary Sabbath-oriented (Holiness) Stratum, and Arguments for literary unity. This article gathers older and new arguments to advance the hypothesis of a secondary Sabbath-oriented stratum.
Why Prophets Are (Not) Shamans?
Authors: Nissinen Martti
Published: January 2020

The article explores the interface of prophecy and shamanhood from the point of view of intermediation, divination, and magic; performance and cosmology; gender; and social status. The most significant thing in common between prophets and shamans is the role of an intermediary and the superhuman authority ascribed to their activity. Other similarities include the performance in an altered state of consciousness, gender-inclusiveness, as well as some ritual roles and forms of social recognition. The action of the prophets rarely reaches beyond the transmission of the divine word, whereas the shamans’ activity is more strongly oriented towards ritual efficacy. The cosmological explanation of prophetic and shamanistic performance is different, and the transgendered roles of the shamans appear stronger. The social status varies according to the different community structures reflected by the source materials. It is argued that, even though the conceptual difference between prophets and shamans should be upheld, there is a strong interface between the two phenomena.
Jugend—Alter—Tod
Authors: Spieckermann Hermann
Published: January 2020

Koh 11:7-12:8 is understood as the last part of Kohelet’s collected reflections, except for minor later additions. It resumes central topics addressed previously and correlates them to phases of human existence: youth and adulthood, (old) age and, finally death. It will be shown that the unique allusion to death by using the metaphor of “house of eternity” conveys the idea of a certain stability surrounded by examples how the beauty of creation and the products of human artistry are threatened by transitoriness, decay, and destruction. Consequently they become a paradigm of death—the way all human beings have to go. Joy pursued in the first decades of life and the “house of eternity” are not contradictory. Rather, both are regarded as positive options of human existence surrounded by the omnipresence of futility. It cannot even be excluded that Kohelet implicitly ponders a relation between the eternity God has given into the human heart (3:11) and the “house of eternity” (12:5). After all, these are the only significant instances of eternity in his collection.
Wolfhart Pannenberg’s Postfoundational Ecclesiology
Authors: Yang Jae
Published: January 2020

This article interprets Wolfhart Pannenberg’s ecclesiology through a postfoundational framework. Pannenberg’s postfoundational theological methodology, based around the centrality of sub ratione Dei, is a dialectical relationship between the ‘from below’ movement of context (‘true infinite’) and the ‘from above’ movement of universal truth (Trinity) which reflects the differentiation-in-unity found in the immanent and economic Trinity. Accordingly, this article argues, Pannenberg’s ecclesiology, including his understanding of church essence (its role in creation and its constitutive members) and its activities (baptism, Eucharist, ministry) displays postfoundational relations between the particular and the universal bridging the divide between the secular and the sacred, the past, present, and future, and individual and community. In the discussion, concepts such as Christ’s ‘person,’ ‘transignification,’ Christocentric election, and social trinitarianism are used to move the discussion past modern dualism and postmodern relativism and toward postfoundational relationality.
Democracy, Oil and Political Stability in West Africa: Pathways to Managing Contested Spaces
Authors: Darkwa Linda , Attuquayefio Philip
Published: January 2020

The discovery of oil in commercial quantities in Ghana, Liberia, Sierra Leone, and Niger has generated optimism of a better life for the people living within the respective countries. This notwithstanding, the narrative surrounding African countries such as Nigeria and Angola as examples of the resource curse syndrome is well documented. Consequently, the conversation on the prospects from the discovery of oil is often measured. Within this context, this article explores the relationship between oil, democracy and political stability in West Africa. While conceding that countries which discovered oil post-democracy will likely avoid the challenges of those that struck oil prior to democracy, it is argued that such prospects are merely conditional due to inherent challenges in the democracy project practised in respective countries in the sub-region. The article thus argues that the pathways to addressing the contested spaces lie in democratic institutions with enhanced institutional capacity.
Four new species of Pteronia (Astereae, Asteraceae) from South Africa

Authors: BELLO ANIFAT O. , BOATWRIGHT JAMES S. , VAN DER BANK MICHELLE , MAGEE ANTHONY R.
Published: January 2020

During taxonomic studies of the southern African genus Pteronia, four new species, P. armatifolia, P. decurrens, P. flava and P. glandulosa were uncovered from the Northern and Western Cape provinces of South Africa. We formally describe these four new species here and provide detailed descriptions, diagnostic characters, geographical distributions, as well as ecological information for each of the species.
Ophichthus kailashchandrai sp. nov. (Anguilliformes: Ophichthidae): a new species of snake eel from Indian waters, Bay of Bengal
Authors: MOHAPATRA ANIL , RAY DIPANJAN , MOHANTY SWARUP RANJAN , MISHRA SUBHRENDU SEKHAR
Published: January 2020

A new snake eel (Anguilliformes: Ophichthidae: Ophichthinae) species, Ophichthus kailashchandrai sp. nov., is described from three specimens, collected from the Shankarpur fishing harbour located on the northern part of the Bay of Bengal, West Bengal, India. Ophichthus kailashchandrai sp. nov. is distinguished from its congeners by having its dorsal-fin origin at the posterior third of the pectoral fin, preanal length 2.6–2.8 in TL, uniserial maxillary and mandibular teeth and vertebral count (predorsal vertebrae 14–15, preanal vertebrae 54–55, and total vertebrae 180–182).
A checklist and host catalogue of the aphids (Hemiptera: Aphididae)
held in the Australian National Insect Collection
Authors: BRUMLEY CAMERON
Published: January 2020

The aim of this paper is to provide a checklist for Australian collected aphids present in the Australian National Insect Collection. Host plants for each species are provided, alongside Australian State and territory distribution. Six species are documented for the first time in Australia: Aphis forbesi, Micromyzella filicis, Trichosiphonaphis polygoni, Wahlgreniella nervata, Reticulaphis distylii and Reticulaphis inflata. A total of 137 new host plant associations are documented, spread across 51 species of aphids. A list of the remaining species previously published as present in Australia is also included.
lncRNA Metallothionein 1J Pseudogene Positively Regulate miRNA-383 to Suppress Osteosarcoma Biological Activities via Wnt Pathway
Authors: Liu Wei , Wang Bin , Ju Shaojing
Published: January 2020

Background: Osteosarcoma is a type of primary bone tumor that usually occurs in the metaphyseal region of long bones. It has been unclear lncRNA MT1JP in osteosarcoma development. Material and Methods: The MG63 cell were respectively MT1JP, miRNA-383 and miRNA-383 inhibitor.
Measuring the cell proliferation, apoptosis and cell cycle by MTT and flow cytometry and evaluation the MG63 cell invasion and migration by transwell and wound healing assay in difference groups. The relative proteins (Wnt, β-catenin, Cyclin D1, MMP-2 and MMP-9) were measured by
Western blot (WB) assay. By luciferase target assay, analysis the correlation between miRNA-383 and Wnt in MG63 cell. Results: Compared with WT group, the cell proliferation rate of pcDNAMT1JP and miRNA-383 groups were significantly down-regulation with cell apoptosis rates and G1 phase
rates were significantly increased (P < 0.01, respectively). By transwell and wound healing assay, the invasion cell number and wound healing rate of pcDNA-MT1JP and miRNA-383 groups were significantly depressed (P < 0.01, respectively). By WB assay, Wnt, β-catenin,
c-Myc, MMP-2 and MMP-9 proteins expressions of pcDNA-MT1JP and miRNA-383 groups were significantly suppressed compared with those of WT group (P < 0.01, respectively). By luciferase target assay, Wnt was the targeted gene of miRNA-383 in MG63 cell. Conclusion: MT1JP could
suppress osteosarcoma cell lines MG63 cell biological activities via stimulating miRNA-383 and depressing Wnt pathway.
Transparent Bipolar Thin Film Transistors Based on Topological Insulator of Magneto-Resistive Effect
Authors: Oh Teresa
Published: January 2020

Thin film transistors using SiOC insulation film generated a very large IDS current with tunneling phenomena due to the occurrence of space charge limit current due to magnetic resistance effect. When SiOC gate insulation barrier transistor characteristics were investigated,
transmission characteristics of bi-directional were observed, low current at levels ~10−7 A, but switching characteristics were superior to or greater than 10−10 A. SiOC Thin Film Insulation Characteristics are a good material for observing magnetic resistance
effects, SiOC Transistors without channels clearly demonstrate the difference in spatial charges due to electromagnetic phenomena, and even in low-current insulation, nano-current flows at high speed. The current due to magnetic resistance is bi-directional and has an alternating current that
flows in both directions at 0 V.
Effect of Randomly Grown Morphology of ZnO Nanorods in Inverted Organic Solar Cells
Authors: Zafar Muhammad , Khan Shenawar Ali , Sher Fatima , Ali Muddassir , Manzoor Tareq , Rahman Sheik Abdur , Kim Woo Young , Saleem Mahmood , Kim Do-Heyoung
Published: January 2020

Here, we analyzed the photovoltaic properties of the inverted organic solar cells (IOSCs) by using randomly oriented medium density ZnO nanorods (ZnO-NR) synthesized hydrothermally at low temperature conditions to avoid morphological defects. The IOSC with ZnO-NR (length < 150 nm)
of medium density and random orientation showed an improvement of 83% in power conversion efficiency compared to the cell with (length < 20 nm) hydrothermally grown ZnO-NR. The optimized hydrothermal growth conditions for ZnO-NR enhanced the photovoltaic performance indicators by reducing
recombination rate evidenced by the photovoltaic data. The qualitative elemental analysis of the ZnO-NR based interface was performed by the EDX, which confirmed that the as-grown ZnO-NR contain the Zn and O elements.
The Effect of Mn and Ca Addition on the Microstructure and Mechanical Properties of the Al–Cu–Fe–Si–Zn Based Alloys
Authors: Yoo Hyo-Sang , Kim Yong-Ho , Lee Seong-Hee , Son Hyeon-Taek
Published: January 2020

High conductivity Al alloys are widely used for electric materials, heat exchangers, and heat dissipation parts such as electric conductors, transmission lines, communication cables, automobile wires and so on. In this study, the effects of Ca and Mn addition on the microstructure and
mechanical properties of Al–0.3Cu–0.2Fe–0.15Si–0.15Zn alloys were investigated. The melt was held at 800 °C for 20 minutes and poured into a mold. The cast Al alloy was hot extruded with a rod having a diameter of 12 mm and a reduction ratio of 38:1. Al–0.3Cu–0.2Fe–0.15Si–0.15Zn–0.9Mn–0.4Ca
alloy consists of Al, Al–(Fe, Mn)–Si, Al–(Fe, Mn) and Al–(Ca) intermetallic compounds. The formation of the intermetallic compound and this phase was broken in to small particles during extrusion. As the Ca content increased from 0 to 0.4 wt.%, the electrical conductivity
of the extruded Al–0.3Cu– 0.2Fe–0.15Si–0.15Zn alloys increased by 57.3, 57.9 and 59.0 %IACS (International annealed copper standard). Al–0.3Cu–0.2Fe–0.15Si–0.15Zn–0.9Mn alloy with element additions of Ca, ultimate tensile strength was decreased
from 178.3 to 163.2 and 151.8 MPa. However, the elongation was improved to 18.6, 21.6 and 23.15%.