bluuebunny/crossref_metadata_2025 huggingface dataset:
FEATURES IN SPORTSMEN MOTION PERCEPTION DEPENDING ON THE DIRECTION TRAINING PROCESS
Authors: Gurova M. B. , Kapilevich L. V.
Published: June 2020

By recording the visual and somatosensory evoked potentials were studied especially the perception of movements of athletes depending on the focus of the training process. Shown that the development of systems of perception of space and movement occurs depending on the nature of the training process. In weightlifting identified the following features: the predominance of somatosensory perception, reference system for coordination is his body, the prevalence of central vision, attention. At the same time to combat sports preponderance of visual perception, reference system for the coordination of movements are external objects, the prevalence of peripheral vision, increased ability to recognize and differentiate incentives.
URGENT AND LAG PSYCHOPHYSIOLOGICAL EFFECTS NEUROFEEDBACK IN SPORTSMEN OF HIGH QUALIFICATION
Authors: Kaigorodtseva O. V. , Talamova I. G. , Tristan V. G.
Published: June 2020

The article provides a comparative analysis of the psychophysiological state of sportsmen of high qualification within one year after the course neurofeedback. These data demonstrated that high qualification sportsmen physiological effects of training persist throughout the year and depend on the ability to arbitrarily increase the power of the alpha rhythm of the brain.
PAIR MOTOR COORDINATION ACTION IN SPORTSMEN (ON THE EXAMPLE OF BALLROOM DANCING)
Authors: Kapilevich L. V. , Bredikhina Yu. P.
Published: June 2020

Learn a special coordinating pair of motor actions in athletes engaged sport ballroom dancing, depending on gender and sportsmanship. The results suggest that beginners dominated coordination, performed individually, while the highly skilled dancers better developed coordination, carried out in pairs. Athletes average individual coordination disturbed by the emergence of sex differences build movements and coordination pair is not formed. The asymmetry of the coordination abilities manifested in the predominance of the deviation from equilibrium (to the right of men and to the left – in women). In this case, the athletes of low and medium level of skill to maintain the leading element of balance and coordination is the visual analyzer, while the skilled dancers defining role goes to the vestibular apparatus.
NEUROFEEDBACK INFLUENCE ON CEREBRUM BIOELECTRICAL ACTIVITY IN GYMNASTS-WOMEN
Authors: Strizhkova T. Yu. , Cherapkina L. P. , Strizhkova O. Yu.
Published: June 2020

The analysis of electroencephalogram (EEG) of highly skilled gymnasts-women (main group – 49, control group – 39) showed the availability of cerebrum bioelectrical activity features of sportswomen connected with left hemisphere dominance, predominance of theta-rhythm power and lower reaction to eyes closing, also character of neurodynamic changes generated by neurofeedback course depended on ovarian-menstrual cycle phases.
A GENERAL MODEL FOR UNIFICATION OF THE THREE PROCESSES OF SLEEP-WAKE REGULATION
Authors: Putilov A. A. , Verevkin Ye. G.
Published: June 2020

The most-known model of sleep-wake regulation includes different formulae describing the kinetics of three separate processes, i.e., homeostatic, circadian, and ultradian. We tried to explain all these processes within a more parsimonious modeling framework and to use the EEG recordings of baseline night sleep for derivation of the model’s parameters and for prediction of the effects of experimental manipulations with sleep-wake regimen.
PROGRAMMING GENES IN BRAIN AND PROBLEM OF SOCIAL BEHAVIOR ОF MAN
Authors: Fuks B. B.
Published: June 2020

Transcription factors programmed genes of brain cells. Then proteins synthesized form long term memory. Two genes of hormone vasopressin receptor – genes of altruism / selfishnessand one oxytocin receptor gene provide social recognition, memory and behavior. Human population divided into three groups: homozygous altruists, homozygous egoists and heterozygous group containing both vasopressin genes. Behavior genes programming in the last group occurs within the first two weeks of life. Negative programming of masses of people in this group could be the cause of social disasters in the twentieth century.
THE EFFECTS OF INSTRUCTIONS ON THE EFFICIENCY OF EEG ALPHA POWER VOLUNTARY INCREASE TRAINING
Authors: Lazareva O. Yu. , Bazanova O. M.
Published: June 2020

We studied how the efficiency of individual alpha power stimulating training depends on the use of instructions and the presence or absence of feedback. A new method of calculating the efficiency of a single training session was suggested.
BIOFEEDBACK IN THE MAGNETIC FIELD (ON STEREOTOPOGRAPHY OF COGNITIVE FUNCTIONS)
Authors: Mazhirina K. G. , Pokrovskiy M. A. , Rezakova M. V. , Savelov A. A. , Sokolov A. A. , Petrovskiy Ye. D. , Levshakova Ye. A. , Ganenko Yu. A. , Shtark M. B.
Published: June 2020

The brain was mapped on-line using fMRI technology in the process of the development of self-regulation skills. We studied the dynamics of new neural networks being created in the real and simulated biofeedback models. It was shown that immersion in a virtual story brings about the large involvement of cortical areas, which are characterized by high values of voxels in the middle-temporal, occipital and frontal regions. We discuss the qualitative characteristics of the real and the imitation game periods.
THE DEPENDENCE OF THE SUCCESS RATE OF ALPHA-TRAINING ON EXTRAVERSION AND NEUROTICISM
Authors: Chernyshev B. V. , Osokina Ye. S. , Ilyushina N. V. , Trunova M. S. , Chernysheva Ye. G.
Published: June 2020

The present paper shows the relationship of the success rate of alpha-training – learning to voluntarily increase the power of the alpha-rhythm with the help of the neurofeedback – with factors of the "Big Five" model of personality traits (NEO–FFI). It was found that most successful at the task of training were the subjects with low scores on Extraversion dimension and moderately high scores on Neuroticism dimension.
NEUROPHYSIOLOGICAL ASPECTS OF THE BIOBEHAVIORAL THERAPY IN DISORDERS OF PERSONALITY
Authors: Zagoruyko E. N. , Shubina O. S.
Published: June 2020

In this work the suggested method of biofeedback is one of those unique practices, which enables to find an individual approach to every patient, consider his character traits, and, in addition to this, the patient himself comes to realization of the problem, that is not so easy with personality disorders. Biofeedback therapy results not only in the change of physiological data, but also of cognitive stereotypes and behavioral patterns, which makes it possible to optimize the social, professional and interpersonal functioning of a patient.
ETHICAL DIMENSIONS OF THE FETUS AS A PATIENT
Authors: Chervenak F. A. , McCullough L. B.
Published: June 2020

Objective: To describe the ethical concept of the fetus as a patient and identify its implications for the deliberative practice of perinatal medicine.Methods: We describe secular medical ethics and its two fundamental principles, beneficence and respect for autonomy. We articulate the ethical concept of the fetus as a patient on the basis of the ethical principle of beneficence.Results: In the deliberative practice of perinatal medicine guided by the ethical concept of the fetus as a patient, the perinatologist should always identify and balance beneficence-based obligations to the fetal patient and beneficence-based and autonomy-based obligations to the pregnant patient. Directive counseling is appropriate when the fetus is a patient. Non-directive counseling is appropriate when the fetus is not a patient.Conclusion: Counseling pregnant women about the clinical management of their pregnancies should always identify and balance beneficence-based obligations to the fetal patient and beneficence-based and autonomy-based obligations to the pregnant patient.
АNTIARRHYTHMIC ACTIVITY OF DIBORNOL IN THE MODEL OF АСUTE MYOCARDIAL ISCHEMIA/REPERFUSION
Authors: Shchetinin P. P.
Published: June 2020

We studied the аntiarrhythmic activity of novel sterically hindered phenols – 4-methyl-2,6diisobornilphenol (dibornol) in acute myocardial ischemia/reperfusion in male Wistar rats. Left coronary artery occlusion (10 min) in control group induced different ventricular arrhythmia and 23% mortality of animals. Dibornol (p.o. administration 100 mg/kg 24 and 3 hours before ischemia) did not change frequency and kinds of arrhythmia in acute ischemia, but significantly reduced the frequency and serious of arrhythmia in the reperfusion period, decreased the mortality of rats due to lethal arrhythmia.
THE HISTORY OF CREATION AND DEVELOPMENT OF THE RUSSIAN SCIENTIFIC MEDICAL SOCIETY OF PHYSICIANS
Authors: Beloborodova E. I. , Beloborodova E. V. , Kalacheva T. P.
Published: June 2020

The history of a scientific medical society of physicians in Russia and Tomsk. Describe the contribution of outstanding scientists and clinicians in the development of society practitioners, as well as large schools known not only in Russia but also abroad. Outlines the achievements of the last decade.
VICTOR IVANOVICH MOSCVIN. TO THE BLESSED MEMORY OF A TEACHER (TO THE 100th ANNIVERSARY FROM BIRTHDAY)
Authors: Shalygin V. A. , Melnik D. D.
Published: June 2020

Viktor Ivanovich Moskvin – largest children's surgeon, Professor, doctor of medical Sciences, the student of the founder of Siberian school of pediatric surgery of Professor I.S. Vengerovsky.
INVESTIGATION OF NEUROPROTECTIVE ACTIVITY THIOPHANE INVOLUTIONAL CHORIORETINAL DEGENERATION IN RATS OXYS
Authors: Zhdankina A. A. , Kon G. A. , Plotnikov M. B. , Varakuta Ye. Yu. , Logvinov S. V. , Prosenko A. Ye. , Kolosova N. G.
Published: June 2020

The method of spontaneous and induced luminol -dependent chemiluminescence in homogenates of rat retinas OXYS registered increase in the generation of free radicals against decrease in total antioxidant  activity.  With  the  ultra-microscopic  and  quantitative  analysis  revealed  degenerative retinal neurons rats OXYS: the percentage increase in neurosensory cells with pyknosis of nuclei, hyperchromatic piknomorfnyh associative neurons and ganglion n eurons that have been modified on a light and dark type. Thiophane, limiting free radical reactions in the retina and protects retinal neurons from damage.
INFLUENCE OF COMPOSITION OF POLYUNSATURATED FATTY ACIDS ON MICROVISCOSITY OF THE MEMBRANE OF ERYTHROCYTES OF THE NAVEL OF THE BLOOD AT HERPES INFECTION CONTAMINATIONS
Authors: Isutina N. A.
Published: June 2020

The method of gas-liquid chromatography investigates composition of polyunsaturated fatty acids of membrane of erythrocytes, discharged of navel bloods neonatal from mothers who have transferred in the season gestation exacerbation herpes of an infection contamination and his influence on microviscosity of membrane. Essential infringements of data exchange of bonds in navel bloods neonatal with an exacerbation  herpes  infection  contaminations  (antiserum  capacity  IgG  to  virus  of  simple  herpes  of  1  type 1 : 12 800) which show deficiency essential ω-3 acids at simultaneous augmentation of the precursor proinflammatory eicosanoid ω-6 arachidonic acids, promoting augmentation of relative microviscosity of membrane of erythrocytes that will be one of probable causes of development of hypoxia are found.
SUPRESSION OF MICROSOMAL OXIDATION WEAKENS HISTOCHROME’S DIURETIC EFFECT AT RATS
Authors: Talalaeva O. S. , Zharikov A. Yu. , Zverev Ya. F. , Fedoreyev S. A. , Bryukhanov V. M. , Lampatov V. V.
Published: June 2020

Histochrome is the medicinal form of echinochrome (2, 3, 5, 6, 8-pentahydroxy-7-ethyl-1,4-naphthoquinone). Arisen during clinical application of the drug questions concerning its biotransformation have predetermined the aim of this research: to study participation liver monooxygenase system in maintenance of histochrome’s pharmacological activity.Simple and informative method of the lifetime control of liver monooxygenase systems influence on a metabolism of a medical product is the estimation of changes of pharmacological effect of a r esearched preparation on a background microsomal oxidations i nhibitor. In experiments on rats chloramphenicol action on diuretic effect of histochrome, as the most convenient for screening, was i nvestigated.To control group of animals during 10 days were hypodermically entered by histochrome in a doze of 10 mg/kg (n = 15). Experimental animals preliminary oral received 50 mg/kg of chloramphenicol before three hours of histochrome introduction (n = 16). In both groups of animals measured volume daily excretion of water, creathinin, sodium and potassium ions excretions in experimental rats each two days. The initial level of parameters of excretory kidneys functions were estimated before introduction of preparations at animals.Long-term histochrome’s injection was followed by a fivefold increasing of water excretion and simultaneously creathinin growth one. Allocation of ions of sodium was statistically significantly increased by 11-th day of experiment, and potassium ions – since the ninth day of histochrome injection. In conditions preliminary chloramphenicol applications volume daily daily urine output and creathinin excretion were essentially less control parameters. Allocation with urine of ions of sodium was decreased almost twice in comparison with the values, fixed at introduction histochrome. Excretion potassium ions ware corresponded to an initial level during all period of supervision.Taking into account, that chloramphenicol is powerful inhibitor of microsomal oxidations in a liver, it was logical to assume, that excretion functions decrease of kidneys was connected to oppression of the echinochrome metabolism, and the diuretic effect of a preparation was caused not so much primary substance, how many of its metabolism products. Most likely, echinochrome metabolite raises speed glomerular filtrations, providing diuretic reaction of a preparation.
AUTOIMMUNE OOPHORITIS AND THEIR CORRECTION BY GLUCOCORTICOIDS
Authors: Tupitsyna T. V. , Logvinov S. V. , Tikhonovskaya O. A. , Dmitrieva M. L.
Published: June 2020

Autoimmune oophoritis (AO) is characterized by damage of generative and endocrine elements of the ovaries and leads to the formation of secondary insufficiency of the gonads. A question about the use of glucocorticoids (GC) for the correction of AO remains debatable.Objective: to study the electron-microscopic changes of structural-tissue cells in autoimmune ovariano ophoritis and after its correction by glucocorticoids in the experiment.The material. The experiment was performed on outbred white Mature rats-female. The main group of animals (12 rats) were simulated AO by intra-peritoneal introduction of antigens of ovarian. At 5th day prednisolone was injected to rats («Nycomed», Austria) in the dose of 3 mg/kg of body weight intramuscularly 14-day course. A comparison group (12 rats) were the animals with the model AO no course Ledger therapy. Controlintact rats (6 animals). Taking of the material was carried out by the 20th and the 60th day.Methods. The study of the ultrastructure ovaries were performed using transmission electron microscopy. The material was fixed 2.5% glutaraldehyde, postfixed in 2% solution of osmium tetroxide, dehydrated in ethyl alcohols rising concentration and placed in a mixture of resins Epon-Araldite. Sections were prepared on Ultrotom III (LKB, Sweden). To view the drugs used an electron microscope JEM-7A (Japan). Results. On the 20th day of the pilot AO there are significant ultrastructural changes of vessels, concerning mainly endothelial layer. Degenerative and destructive changes affected endocrinocytes in the composition of the libraries and granular, овоциты majority of antral follicles. The 60-day pathologic processes involved and preantral follicles in the medulla develop perivascular fibrosis-sclerotic changes. Holding GC therapy on the 5th day AO reduces ultrastructural breach the walls of blood vessels, limits migration of immune cells in the home defeat on the 20th day. By the 60th day in the conditions of the restored the blood tissue transport is the formation of full-fledged generative elements, confirmed by the results of electron microscopy study.Conclusion. The obtained experimental data are demonstrated the therapeutic efficacy of the GC-therapy in the early stages of AO.
IMMUNOLOGIC RISK FACTORS OF DEVELOPMENT OTITIS MEDIA WITH EFFUSION IN CHILDREN SUFFERING FROM CHRONIC ADENOIDITIS
Authors: Scherbik N. V. , Klimov A. V. , Kologrivova Ye. N. , Fyodorova O. V. , Komarova S. V.
Published: June 2020

There were 24 patients with chronic adenoiditis in the 1st group, another 24 patients with chronic adenoiditis in association with otitis media effusion (OME) were included in the 2d group. The study of mucosal immunity included assessment of SIgA, IL-6, IFN- and IL-10 levels in nasal washes. Decrease of SIgA content and increase of the number of IFN-γ-positive samples was revealed in children from the 2nd clinical group, which allows to regard these characteristics of the mucosal immunity as the risk factors for the development of otitis media with effusion.
HIGH-RESOLUTION CONTRAST-ENHANCED MRI IN DIFFERENTIAL DIAGNOSIS OF TYPE OF CAROTID PLAQUE AND IT'S RELATIONSHIP TO THE ISCHEMIC BRAIN DAMAGE
Authors: Bobrikova Ye. E. , Ussov V. Yu. , Shcherban N. V. , Khaneev V. B. , Shelkovnikova T. A. , Bukhovets I. L. , Plotnikov M. P. , Shipulin V. M.
Published: June 2020

Aim of the study. We have compared in patients with carotid atherosclerosis the patterns of contrast enhancement of atherosclerotic plaque with presence of cerebral stroke, by using of high-resolution contrast-enhanced carotid MRI.Material and methods. The patients 'population comprised 26 persons with either monolateral (14 pts) or bilateral (12 pts) stenosis of internal carotid artery for over 70% of lumen. In 15 (10-monolateral, 5 bilateral stenosis) there was recent stroke in acute or subacute stage, whereas 11 were symptom-free. In everybody contrast-enhanced study of atherosclerotic plaque was carried out with T1-w high-resolution MRI (paramagnetic as 2 ml of 0.5 mol solution per 10 kg of BW).Results and discussion. In control persons there was a mild increase in T1-w intensity of arterial wall of carotids? With IE not more than 1.08. In patients without stroke there was moderate increase in plaque T-1w intensity up to 1.14 ± 0.07. In ishaemic stroke patients there was significant rise in intensity of T1-w of homolateral plaque (IE = 1.35 ± 0.06), and also of T1-w of arterial wall as whole (IE = 1.19 ± 0.05).Conclusion. Further detailed study of high-resolution MRI of carotids is worth in order to obtain better imaging of atherosclerotic lesions and also better evaluation of risk of stroke in patients suitable for carotid endarterectomy.
SCHILDER’S DISEASE (CASE)
Authors: Alifirova V. M. , Valikova T. A. , Nikolaeva T. N. , Pugachenko N. V. , Vtorushin S. V.
Published: June 2020

Schilder’s leukoencephalitis was described by American neurologist and psychiatrist P.F. Schilder (1886– 1940). At present the pathology is regarded as acute diffuse form of multiple sclerosis, and it is characterized by demyelination of the brain. Clinical manifestations of pathological process varied. The disease is a rare, usually in children and adolescents. In patients older than 40 years of death can occur in a period of 6 months to 3 years from the onset of the first symptoms. Considering the rarity of the disease, we present a clinical case with autopsy data from our practice.
THE TOMSK SCIENTIFIC SCHOOL OF NEUROLOGISTS. TO THE 120TH ANNIVERSARY OF THE DEPARTMENT OF NEUROLOGY AND NEUROSURGERY OF SIBERIAN STATE MEDICAL UNIVERSITY
Authors: Alifirova V. M. , Azhermacheva M. N.
Published: June 2020

The history of the development of the Tomsk Scientific School Neurologists and the past and current events in the Department of Neurology and Neurosurgery of Siberian State Medical University are described. The Department of Neurology was established in 1881–1882. At a different times the department was headed by many great Russian physicians such as Michail G. Kurlov, Leonid I. Omorokov, Nikolay V. Schubin, Nikolay I. Komandenko. In addition to the academic work the department leads research in many fields of neurology, including movement disorders, cerebrovascular diseases, demyelinating and paroxysmal diseases.
ANALYSIS OF THE RELATIONSHIP DIAGNOSED MILD COGNITIVE IMPAIRMENT IN ELDERLY AND SENILE PATIENTS WITH CERTAIN FEATURES OF MEDICAL HISTORY AND DEPRESSION
Authors: Maslova N. N. , Iusov A. Ye.
Published: June 2020

Are defined frequency of mild cognitive impairment (MCI) at patients of advanced and senile age with chronic ischemia of a brain (HIGM) in comparison with frequency of existence of a depression, an education level and the place of residence and their interrelation. 100 patients with HIGM 2 age групп: 1 – advanced age (from 60 to 74 years – 48 people), 2 – senile age (from 75 to 89 years – 52 persons) are surveyed. In research didn't join: patients with Alzheimer's disease and other forms of a dementias. Diagnostics of UKN it was carried out by means of a short scale of an assessment of the mental status (MMSE). For an assessment of existence of a depression – Bek's scale. For objective justification of conclusions from results of the carried-out research the statistical analysis of primary information was used.
OUTCOMES OF TICK-BORNE ENCEPHALITIS IN THE TOMSK REGION
Authors: Pinegina T. S. , Zhukova N. G. , Bartfeld N. N. , Malysheva L. A. , Udintseva I. N. , Kemerova Z. S. , Martynova N. I. , Burov O. V. , Poltoratskaya T. N. , Shikhin A. V. , Lukashova L. V.
Published: June 2020

The results of the study outcomes of tick-borne encephalitis in adults in the Tomsk Region. Patients conducted a comprehensive clinical and laboratory examination. Revealed the prevalence of autonomic disorders in individuals who have had at different periods of tick-borne encephalitis, which is regarded as the effects of tick-borne infection. Residual effects of tick-borne encephalitis occurs mainly in the form of light paresis after suffering a focal forms. Among the chronic (progredient) forms of tick-borne encephalitis often formed hyperkinetic options. Most of the study revealed the presence of precipitating factors that could have an influence on the outcome. Fundamental diffe rences in all-clinical and immunological analyses at patients with various outcomes of tick-borne encephalitis it wasn't noted. KEY WORDS: tick-borne encephalitis, Tomsk Region, the outcomes.
RELATIONSHIP OF CHARACTERISTICS OF MUSCULAR COORDINATION, BALANCE AND THE OF THE VEGETATIVE-VASCULAR DEPENDENTS ON DANCERS
Authors: Bredikhina Yu. P. , Kapilevich L. V.
Published: June 2020

Study the relation between the characteristics of muscle coordination, balance, and - vegetative-vascular balance on dancers. The dependence of balance and coordination abilities of the nature of the muscle and, in turn, from the vegetative-vascular support activities. The method of correlation analysis were confirmed by the relationship of coordination abilities with the characteristics of the bioelectrical activity of the muscles and vegetative-vascular support. All the above allows us to consider the formation of skills in ballroom dancing as a single functional system, in which the sense of balance and coordination abilities that determine the skill level of athletes associated with the information field of visual and vestibular reception, to the organization of the contractile activity of muscles and vegetative-vascular maintenance activities.
PREVENTION OF ERYSIPELAS IN THE EARLY POSTOPERATIVE PERIOD AFTER THE IMPOSITION MIKROLIMFOVEIN ANASTOMOSIS IN PATIENTS AFTER BREAST CANCER LYMPHEDEMA
Authors: Smagin M. A. , Lubarsky M. S. , Shumkov O. A. , Nimaev V. V. , Poveshenko O. V.
Published: June 2020

The aim of work is valuation of the effectiveness of autologous lymphocytes activated by complex of cytokines to prevent erysipelas of patients with after breast cancer syndrome.

The estimate of influence of activated autologous lymphocytes to erysipelas. The treatment results of 128 patients with secondary lymphedema of the upper limb II–III stage after curative treatment of breast cancer are included in the work.

Activated roncoleukin auto lymphocytes injections were performed in the forearm of the affected limb to the main group’s patients.

17.4% faces relapses were recorded in the comparison group. while the group with the usage of activated roncoleukin autologous lymphocytes had achieved significant reductions in recurrent of erysipelas up to 5%.
PROBLEMATIC ISSUES OF DIAGNOSTICS AND THERAPY OF NON-PSYCHOTIC MENTAL DISORDERS IN FEMALE PATIENTS OF CLIMACTERIC AGE WITH HYSTERICAL SYMPTOM COMPLEX (LITERATURE REVIEW)
Authors: Lukiyanova Ye. V.
Published: June 2020

In the article, problematic questions of diagnostics and therapy of non-psychotic mental disorders (NPMD) in female patients of climacteric age with hysterical symptom complex are considered. Efficacy of psychotherapy (PT) in NPMD, hypnopsychotherapy in hysterical states: hysterical neurosis, neurasthenia and obsessive-compulsive neurosis is indicated. In treatment of NPMD, PT by creative selfexpression is successfully used. It is highlighted that PT forms conscious-critical attitude of patients toward themselves. Combination of PT with physiotherapy in hysterical conversional symptoms has been described. In hysterical manifestations neuroleptics are recommended, in neurotic depressions – antidepressants of mild action. In severe hysterical state, psychopharmacotherapy (PPhT) with tranquilizers and neuroleptics is applied on long-term basis. Stable recovery in dissociative and hysterical disorders has been shown. In vegetovascular disorders in structure of climacteric syndrome (CS) vinpocetine, in psychoemotional manifestations phenibut was administered. In therapy of hysterical neurosis, “minor neuroleptics”, hypnosuggestive therapy, social rehabilitation were applied. Effective group PT of psychogenically conditioned disorders in asthenicand anxiety-depressive symptoms is effective. Complex therapy of NPMD in hysterical and asthenic neurosis, obsessive-compulsive neurosis has been suggested. Organization of specialized preventive examinations for early revealing of persons with personality pathology is based. Efficacy of a number of medications in periand post-menopause – SSRIs and gabapentin, during menopause paroxetine, in depressions of non-psychotic level – pyrazidol, coaxil, in neurotic hypochondriasis sulpiride and quetiapine, diazepam, in climacteric vegetative and mental disorders hormone replacement therapy (HRT), hormonal therapy, PPhT and PT, in neurovegetative symptoms of CS – antidepressants, in psychovegetative syndromes – SSRIs, in dysthymic disorders – tianeptine (coaxil), in involutional hysteria – psychotropic medications and medications of neurometabolic action, in psychoemotional disorders of mild and moderate degree – deprim, in depressive disorders of mild and mean severity – valdoxan has been shown. In climacteric depression, hormonal therapy stops climacteric symptoms.
DISORDER OF INTERCELLULAR CORRELATIONS IN PATHOGENESIS OF FATTY TISSUE INFLAMMATION IN METABOLIC SYNDROME
Authors: Osikhov I. A. , Bespalova I. D. , Bychkov V. A. , Ryazantseva N. V. , Kalyuzhin V. V. , Afanasyeva D. S. , Murashev B. Yu.
Published: June 2020

Due to the fact that nowadays mechanisms of syntropy of pathological conditions and nosological units, united within the metabolic syndrome, remain unclear, the scientific review attempts to summarize data on the role of fatty tissue inflammation in pathogenesis of this symptom complex. The results of recent major foreign studies on evaluation of pro-inflammatory activity of adipocytes and macrophages of the fatty tissue, as well as the data on peculiarities of their interactions in abdominal obesity, which is the main component of the metabolic syndrome, were analyzed. Studing pathogenesis of fatty tissue inflammation from the perspective of evaluation of disorders in cell cooperation will allow to more deeply understand cellular and molecular mechanisms of this process as well as open new avenues for developing new pathogenetically justified approaches to metabolic syndrome treatment.
MECHANICAL PROPERTIES OF LUNGS IN PATIENTS PROGRESSING MUSCULAR DYSTROPHY VARIOUS SEVERITY OF THE DISEASE
Authors: Tetenev K. F. , Bodrova T. N. , Tetenev F. F.
Published: June 2020

Results of research of biomechanics of breathing at patients with progressing muscular dystrophy (PMD) and their interpretation are unique. Compared indicators of ventilating function of lungs and indicators of mechanics of breathing at 31 patients with PMD to 1–2 extent of motive frustration and 17 patients with 3–4 extent of motive frustration. In both groups of sick MVL and OFV-1 are lowered to the same extent, bronchial resistance isn’t increased. In the 2nd group the reserve volume of an expiratory is reduced for the account decrease in force of respiratory muscles is decreased. Elastic draft of lungs is reduced, the coefficient of functional activity of lungs is increased. At spontaneous breath the tensile properties of lungs are lowered, increased elastic fraction of work of breathing. The general nonelastic resistance of lungs is on the average equally increased in both groups at the expense of increase of tissue friction. At 12 sick PMD the abnormal respiratory loop came to light: completely I was absent at 8 patients and at 4 there was no inspiratory or expiratory part of a loop. Changes of indicators of mechanics of breath are the in generally functionally, and are considered as manifestation of compensatory strengthening of function of an intra pulmonary source of mechanical energy.
DYSPNEA ASSOCIATED WITH ANXIETY: MISTAKES AND DIFFICULTIES IN THE DIAGNOSIS
Authors: Tyukalova L. I. , Nemerov Ye. V.
Published: June 2020

Two clinical cases that demonstrate the difficulties diagnosing the causes of shortness of breath, coupled with anxiety, are analyzed. From the standpoint of modern neurophysiology it explains the relationship of these conditions. There were revealed typical diagnostic mistakes: «the effect of precocious focusing", "the negative effect of the narrow specialization
NATRIURETIC PEPTIDE AND HIS PROGENITORS AS PREDICTORS OF PROGRESSIVE POSTOPERATIVE LEFT VENTRICLE REMODELING IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY
Authors: Gutor S. S. , Kazakov V. A. , Suhodolo I. V. , Shipulin V. M. , Babokin V. Ye. , Ogurkova O. N. , Andreyev S. L. , Safonova A. V.
Published: June 2020

The work is devoted to the study of atrial natriuretic peptide (ANP) and its precursors as one of possible predictors of left ventricular repeated remodeling in patients with ischemic cardiomyopathy (ICMP) in the follow-up (postoperative period). Objects of the study are venous blood and intraoperative samples of right atrial auricle. Precursors of NUP were identified in blood serum by the immuno-fluorescence test. Ultrathin slices of auricle biopsy samples were examined with electronmicroscopy with the use of image processing ImageJ software (program). The concentration of NUP precursors in blood plasma and relation of minimal diameter of secretory granules to maximal one in right auricle cardiomyocytes reflect pathological processes taking place in the myocardium of patients with ICMP. Ratio of minimal and maximal diameters of secretory granules is a predictor of chronic heart failure progressing.
HEART RHYTHM DISORDERS IN NEW-BORNS AND INFANTS: CLINICAL COURSE AND PERINATAL RISK FACTORS OF ARRHYTHMIAS APPEARANCE
Authors: Kovalyov I. A. , Usenkov S. Yu. , Svintsova L. I.
Published: June 2020

Clinical course, prognosis and mechanisms of separate forms of heart rhythm disorders in children differ from those in adults. Especially, it refers to new-borns and infants whose conduction system differs by functional and morphologic immaturity. In connection with it, the assessment of natural history of heart rhythm disorders, occurred in a perinatal period, and determination of risk factors of arrhythmia appearance in infants are of some interest. 88 newborns took part in the study. The patients were involved by continuous sampling technique. Risk factors, occurred in a perinatal period and potentially influenced on development of heart rhythm disorders, were assessed. In our study we took biological, gynecologic and obstetric history, data of gestation and delivery course, early and late neonatal period, early infancy, Echo, neurosonography, Holter monitoring with determination of heart rhythm variability, and determined thyroid hormonal status. Maximum specific gravity had extrasystoles – 32.4% – in the structure of idiopathic arrhythmias in infants. Heart rhythm disorders with natural history were kept at six months of life only in 5,4% of children. Persistence of arrhythmias was marked during one year only for WPW syndrome. Heart rhythm disorders are often marked significantly in children whose mothers had acute respiratory disease during the pregnancy, or if the children were born from the first pregnancy, had the signs of central nervous system damage syndromes in an early perinatal period (arrest, intracranial hypertension, convulsive disorder). Disorders of autonomic imbalance of cardiac function and peculiarities of hemodynamics of pulmonary circulation contribute significantly into appearance and persistence of all types of arrhythmias. On the whole, the prognosis of heart rhythm disorders, occurred in the perinatal period, without organic and structural changes of myocardium is favorable. The exclusion can be made for congenital atrioventricular block and some types of supraventricular tachycardia which are not responded to treatment.
OPPORTUNITIES OF CONTACT LITHOLYSIS IN THE TREATMENT OF GALLSTONE DISEASE
Authors: Razmakhnin Ye. V. , Lobanov S. L. , Konovalova O. G.
Published: June 2020

For the treatment of calculouscholecystitis in patients with high-risk surgery in the treatment of choledocholithiasis in an effort to preserve the sphincter apparatus major duodenal papilla are encouraged to use the contact litholysis gallstones saxifragant mixture of octanoic acid – glycerol in a ratio of 1 : 1.The possibility of dissolution of stones in experiments in vitro (n = 51) and in vivo (n = 35), confirmed the low toxicity and high efficiency of the proposed technique. In vitro experiments, for more convenient evaluation was introduced conditional coefficient (K) that reflects the time lithodialysis in minutes per 1 mg of the stone weight. In experiments in vitro: K' = 5.76 (n = 51). It is noted that in the group of stones with low mineralization using saxifragant mixture K' = 4.50 (n = 15), with an average K' = 5.76 (n = 17), high K' = 6.88 (n = 19).In an in vivo experiment used 35 sexually mature rabbits after modeling cholelithiasischolecystitis was made through the introduction of a mixture of saxifragant rate of 0.2 ml/kg body weight once a day. Lowmineralized stones disappeared in all cases (after the double administration) medium mineralizedwhen administered for 3 days or more, the highly mineralized 4 – day of treatment. After treatment, histologically and biochemically, were found pronounced toxic effects of the drug.The clinic is possible to impose mikroholetsistostomy under ultrasound gui dance, irrigation lumen of the gall bladder, treatment of acute inflammation, followed by solvent solubility and control of stones with ultrasound studies, or using fistuloholangiografiyu. When choledocholithiasis, especially when residual common bile duct stones in an effort to preserve the sphincter apparatus ma jor duodenal papilla, possibly through the introduction of a mixture of saxifragant hepaticocholedochus established percutaneously transhepatic under ultrasound guidance, either through drainage nazobi liarny established endoscopically through major duodenal papilla. The advantages of this method compared to peers is less toxic solvent, speed lysing effect, the efficiency of the process calculi with different composition (cholesterol and pigment). Compared with the traditional methods of trea tment of gallstone disease differs minimally invasive and thus significantly reduces the risk of intra -and postoperative complications, both local and general, and significantly shorten the treatment of patients and their stay in hospital.
FEATURES OF MEMORY IN CHILDREN OF PRESCHOOL AGE WITH CONSEQUENCES OF PERINATAL LESIONS OF THE CENTRAL NERVOUS SYSTEM
Authors: Krivonogova T. S. , Mikhalev Ye. V. , Babikova Yu. A. , Ryzhakova N. A.
Published: June 2020

The ability of memory was investigated in 524 children, aged 4 to 7; with remote consequences of perinatal damage of the central nervous system (CNS). A weak memory ability was detected in 42% of children with dysfunctions of the general and fine motility and in 59% of children with impaired speech. Severe gestosis, anemia in pregnancy (stage II) and a delayed intrauterine fetal development were found to have a negative influence on memory shaping process.
GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD
Authors: Kulikov Ye. S. , Ogorodova L. M. , Freidin M. B. , Saltikova I. V. , Deyev I. A. , Selivanova P. A.
Published: June 2020

Introduction: The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma in dynamic during treatment period.Methods: Performed 24-week prospective interventional study in parallel groups. Severe asthma patients was aposterior divided at therapy sensitive and resistant patients according to ATS criteria. Global transcriptome profile was characterized using the Affymetrix HuGene ST1.0 chip. Cluster analysis was performed.Results and conclusion: According to our data several mechanisms of therapy resistance may be considered: increased levels of nitric oxide and beta2-agonists nitration, dysregulation of endogenous steroids secretion and involvement in the pathogenesis of Staphylococcus aureus. Absence of suppression of gene expression KEGG-pathway “asthma" may reflect the low efficiency or long period of anti-inflammatory therapy effect realization.
INVESTIGATED DYNAMICS OF ELIMINATION MAGNETITE NANOPARTICLES OF INHALED IN GUINEA PIGS
Authors: Nosarev A. V. , Abramenko Ye. Ye. , Kapilevich L. V. , D’yakova Ye. Yu. , Selivanova V. S.
Published: June 2020

The article presents the results of a study of the dynamics of histological changes in the guinea pigs respiratory tissues due the process of elimination after a long course of inhaled nanoparticles of magnetite. In the experimental animals lungs as a result of prolonged inhalation nanomagnetite developed an inflammatory reaction, the accumulation of Perls -positive cells. These changes were not even a month later, when the input of magnetite nanoparticles in laboratory animals.
OBESITY AS A RISK FACTOR FOR PULMONARY EMBOLISM
Authors: Vasiltseva O. Ya. , Vorozhtsova I. N. , Karpov R. S.
Published: June 2020

The aim of the study. Based on the data of the Register of new cases of hospital pulmonary embolism (PE) in hospitals in Tomsk (2003–2012), to explore the contribution of obesity to the development of venous thromboembolism.Material and Methods. Study were subjected to medical history and records of autopsies of patients treated in hospitals in Tomsk in 2003–2012, who at patologoanatomic and/or instrumental study revealed pulmonary embolism. The degree of obesity was assessed according to WHO criteria (1997). Statistical processing of the results was carried out using the software package for PC Statistica 8.0 for Windows. To test the normality of the distribution of quantitative traits using the Shapiro–Wilk test and the Kolmogorov–Smirnov with the adjusted Lillieforsa. Check the equality of the population variance was performed using Fisher's exact test and Cochran. Was considered statistically significant level of p < 0.05.The results of the study. In Western Siberia, Tomsk, a register of hospital pulmonary embolism (2003–2012). In the register included 720 patients with in vivo and/or post mortem revealed pulmonary embolism (PE). Analyzed data from medical records and autopsy reports. Revealed statistically significant differences in BMI (p = 0.033) and the presence of obesity (p = 0.002) in patients with pulmonary embolism, holding medical and surgical beds. As of medical, surgical and among patients with thromboembolism, obesity is significantly more common in women than men (p = 0.050 and p = 0.041 respectively). According to the study, obesity grade 1 or 2 alone (at the isolated presence of the patient) is not significantly increased the odds of a massive thromboembolism. However, grade 3 obesity increased the odds of a massive pulmonary embolism by more than 2.7 times (OR = 2.708, CI: 1,461–5,020).
VITAMIN D IN POSTMENOPAUSAL WOMEN IN NOVOSIBIRSK WITH A DIFFERENT STATE OF CARBOHYDRATE METABOLISM
Authors: Ruyatkina L. A. , Ruyatkin D. S. , Iskhakova I. S. , Romanov V. V.
Published: June 2020

The aim of the study was to evaluate the association of vitamin D status with carbohydrate metabolism and anthropometric status in postmenopausal Novosibirsk women.We analyzed correlations of carbohydrate metabolism parameters and body weight with hydroxyvitamin D [25(OH)D] levels using the Spearman test in 60 women. 25(OH)D levels correlations (p < 0.05) with a waist circumference (r = 0.51–0.64), blood glucose and HbA1c (r = 0.55–0.56), C-peptide (r = 0.53), duration of hypertension (r = –0.69) and diabetes (r = – 0.41) differed depending on the condition of carbohydrate metabolism. Insufficient supply of vitamin D through association with abdominal fat deposition, insulin secretion and duration of hypertension contributes to the formation of type 2 diabetes in postmenopausal Novosibirsk women.
PECULIARITIES AND CHARACTERISTICS OF INDICATORS OF THYROID CANCER AMONG RESIDENTS OF TOMSK AND TOMSK REGION
Authors: Vorozhtsova I. N. , Latypova V. N. , Saprina T. V. , Beryozkina I. S. , Zima A. P. , Isaeva A. I. , Lunyova S. V. , Kudyakov L. A. , Pikalova L. V.
Published: June 2020

The analysis of thyroid cancer incidence and its structure among different populations of Tomsk region is presented. We studied the report documents, the database of the Tomsk regional oncologic dispensary for the period 2008 to 2012. The clinical characteristics of patients with thyroid cancer were summarizes according to sex, age and place of residence. The papillary cancer was the most often diagnosed. It was found that in young patients, thyroid cancer was diagnosed more often in the stage 1 and 2. On the other hand, in elderly patients (above 60 years), thyroid cancer diagnosed at stage 3 and 4. In the Tomsk region, as elsewhere in the world, thyroid cancer is detected more often in women.
PRE-NEOPLASTIC AND NEOPLASTIC CHANGES IN BRONCHIAL EPITHELIUM OF PATIENTS WITH SQUAMOUS CELL LUNG CANCER AND LUNG ADENOCARCINOMA
Authors: Pankova O. V. , Perelmuter V. M. , Tuzikov S. A. , Denisov Ye. V.
Published: June 2020

The data on modern views on the problem of pre-cancerous changes (epithelial hyperplasia, squamous metaplasia, preneoplasia (dysplasia I) and neoplasia (dysplasia II-III) when squamous cell cancer and adenocarcinoma of the lung are summarizes in the present review. Atypical adenomatous hyperplasia, which is considered precancerous process for adenocarcinoma of the lung, due to the rare occurrence in the review is not considered. The attention is focused on the classification of morphological characteristics of precancerous changes in respiratory epithelium. The analysis of frequency and reversibility of preand neoplastic changes in bronchial epithelium. We discuss the connection between the nature of the changes of respiratory epithelium in the bronchi, developing simultaneously with squamous cell cancer or adenocarcinoma of the lung, with tumour progression.
OXIDATIVE STRESS: ITS ROLE IN INSULIN SECRETION, HORMONE RECEPTION BY ADIPOCYTES AND LIPOLYSIS IN ADIPOSE TISSUE
Authors: Ivanov V. V. , Shakhristova Ye. V. , Stepovaya Ye. A. , Nosareva O. L. , Fyodorova T. S. , Ryazantseva N. V. , Novitsky V. V.
Published: June 2020

Oxidative stress is one of the pathogenetic components of many diseases during which generation of reactive oxigen species increases and the capacity of the antioxidant protection system diminishes. In the research of the last decades special attention has been given to adipose tissue, production of adipokines by it and their role in development of immunoresistance associated with formation of the metabolic syndrome and diabetes.Search for methods of therapeutic correction of adipokine secretion disorders, their influence on metabolism of separate cells and the organism on the whole as well as development of new approaches to correction of disorders in cell sensitivity to insulin are extremely topical nowadays. Systematization and consolidation of accumulated data allow to determine the strategies of further research more accurately; as a result, we have attempted to summarize and analyze the accumulated data on the role of adipose tissue in oxidative stress development.On the basis of literature data and the results of the personal investigations, the role of adipose tissue in forming oxidative stress in diabetes has been analyzed in the article. Brief description of adipose tissue was given as a secretory organ regulating metabolic processes in adipocytes and influencing functions of various organs and systems of the body. Mechanisms of disorder in insulin secretion as well as development of insulin sesistance in type I diabetes were described along with the contribution of lipolysis in adipose tissue to these processes.
THE STATE OF THE ANTIOXIDANT SYSTEM OF THE INTERNAL ORGANS IN RATS DURING BURN DISEASE
Authors: Netyukhailo L. G. , Sukhomlin T. A. , Basarab Ya. A. , Bondarenko V. V. , Kharchenko S. V.
Published: June 2020

The objective of research was to study the state of prooxidant and antioxidant systems in the tissues of the lungs, kidneys, pancreas and salivary glands at burn disease. The intensity of the free radical processes was evaluated on the basis of the content of malondialdehyde (MDA) and antioxidant system – based on the indexes of its enzymatic chain: superoxide dismutase and catalase in homogenates of the studied organs. It has been found that changes in experimental burn disease depend on the studied organs and the stage of burn disease. The activation of free radical processes observed in all investigated organs (lungs, kidneys, pancreas and salivary glands). Reactive oxygen species induce lipid peroxidation, which is a universal marker of tissue damage. MDA appears in the body during degradation of polyunsaturated fatty acids and it’s a marker of lipid peroxidation and oxidative stress. It was found the increasing of MDA in all organs, especially in the lungs and kidneys at stage of burn shock. Under these conditions it was observed the decrease of superoxide dismutase and catalase in all investigated organs. At burn disease there is development of disbalance between the action of prooxidant and antioxidant systems due to the activation of free radical processes.
DEVIATIONS IN MENTAL DEVELOPMENT OF THE OFFSPRING OF RATS WITH EXPERIMENTAL PREECLAMPSIA AND THEIR CORRECTION BY NEW DERIVATIVE OF GAMMA-AMINOBUTYRIC ACID
Authors: Tyurenkov I. N. , Perfilova V. N. , Mikhailova L. I. , Zhakupova G. A. , Lebedeva S. A.
Published: June 2020

The aim of investigation was to study the effect of a gamma-aminobutyric acid´s derivative – a compound RGPU-242 – on the mental development of the rat´s offspring with experimental preeclampsia. Famels’s preeclampsia was modeled    by    replacing    the    drinking    water    of 1.8%    sodium    chloride solution from 7th to the 21th day of gestation. Locomotion, indicative and emotional activity and cognitive functions in progeny were recorded on “Open field”, “One-way step-down inhibitory (“passive”) avoidance”, “Elevated plus maze” and “Test of extrapolative escape” tests in different periods of postnatal development. Found that the compound RGPU-242 has gravidoprotective effect, improves formation and development of mental functions in the offspring.