bluuebunny/crossref_metadata_2025 huggingface dataset:
Sistem Informasi Pemesanan dan Pemasaran Jasa Multimedia Menggunakan PHP dan MySQL Berbasis Website di CV Coklat Multimedia
Authors: Amir Mahfud Maulana , Krishantoro Wahyu
Published: January 2025

Perkembangan teknologi yang demikian pesat menimbulkan dampakbesar terhadap kehidupan sosial bermasyarakat, khususnya bagi instansiatau perusahaan yang membutuhkan sistem informasi komunikasi danpengolahan data secara tepat,cepat dan akurat, Perkembangan yangpesat tidak hanya teknologi perangkat keras, tetapi metode pengolahandata juga ikut berkembang, salah satu metode pengolahan data yangcukup berkembang adalah PHP dan MYSQL. Di era perkembanganteknologi nformasi yang semakin canggih saat ini, ada beberapaperusahaan yang melakukan pemesanan jasa multimedia denganmendatangi ke lokasi, seperti pemesanan foto dan video, seiringberjalanya waktu pemesanan produk secara langsung ke lokasi dinilaikurang efektif karena adanya kesibukan dan kegiatan sehari hari yangdilakukan pelanggan sehingga berdampak kurangnya informasi yangdidapat. Untuk itu di butuhkan sebuah media berupa situs web sebagaisistem pemesanan jasa multimedia, salah satunya di CV CoklatMultimedia, Metode penelitian yang digunakan pada website ini adalahteknik pengumpulan data, yang terdiri dari observasi, wawancara, studipustaka, sedangkan model pengembangan yang dilakukan yaitu analisa,perancangan, pengujian dan implementasi. Sistem informasipemesanan jasa di CV Coklat Multimedia berbasis web ini dapatdigunakan sebagai sumber informasi produk dan pemasaran perusahaandan dapat memperluas jangkauan pemasaran
Sistem Informasi Ujian Teori Mengemudi Audio Visual PT Hanulia Berbasis Web
Authors: Kris Sandy Arul , Subrata Jaka
Published: January 2025

PT. Hanulia merupakan sekolah mengemudi yang ada di Jakarta Utara.Dalam mengikuti kursus mengemudi di PT Hanulia terdapat 2 tahap ujiagar dapat dinyatakan lulus untuk memperoleh surat izin mengemudiyaitu ujian praktik mengemudi dan ujian teori mengemudi, pada ujianteori mengemudi masih menggunakan cara konvensional denganmenggunakan media kertas. Tentunya cara ini kurang efektif karenamemerlukan waktu yang lebih banyak yaitu harus mengoreksi satu persatu untuk mendapatkan skor akhir. Maka dari itu dengan perancangansistem informasi ujian teori audio visual berbasis web diharapkanmampu mengatasi masalah tersebut yaitu dengan memperoleh skorakhir dengan mudah. Perancangan sistem berorientasi pada objek yaitudengan menggunakan metode UML yaitu: Use Case, Activity Diagram,Sequence diagram, Class Diagram. Kesimpulan yang didapat dariproses analisis dan perancangan serta implementasi sistem yaitu,Dengan adanya Sistem Informasi Ujian Teori Mengemudi Audio Visualini diharapkan manajemen yang berjalan saat ini akan lebih baik lagibaik dalam memperoleh nilai akhir atau mengurangi pemakaian kertas.
The Homecoming Readings on Theater inside Syria
Authors: MERHI Mona
Published: January 2025

This research focuses on theater inside Syria during the decade following the Syrian revolution. It examines the theatrical aesthetics of prominent experiences while attempting to understand the impact of everyday life challenges and the internal conflicts on Syrian theater. I argue that similar challenges may create a post-conflict theatrical forms that are informed by a certain sense of allegiance to the city and the art form of the stage. While borrowing Diana Taylor’s concept of multiple allegiances and strategies of doubling and staying the same, the present scholarship looks into the decision of staying inside Syria as both an aesthetic framework and a modus that challenge political polarization.
Sijniyya: New Prison Songs in Sednaya
Authors: BADER EDDIN Eylaf
Published: January 2025

The research Sijniyya: New Prison Songs in Sednaya seeks to study and analyze musical practices from the perspective of personal expression, rather than through the lens of authority and control, contrasting with studies that primarily focus on Syrian prisons. This approach is based on the belief that focusing on personal practices will indirectly reveal the power dynamics within Syrian prisons, especially in Sednaya. Unexpectedly, and by chance, a conversation with a friend suggested that even Syrian torture facilities may hold traces of musical practices. To explore this, the research examines political prisoners affiliated with the Syrian Communist Party, who were politically active in the late 1970s and early 1980s before their imprisonment from 1987 to 1996, and who now live in European exile. Is there a Syrian prison song from Sednaya? Can it be termed ‹Sijniyya'? How can resistance be expressed as a musical or artistic ritual or performance in Sednaya? How might the smaller prison impact the larger prison, shaping the Syrian prison cultural field? This research aims to answer these questions and to shed light on how the system of domination within Syrian prisons reflects Syria itself as a prison, particularly given the scarcity of documentation on prison cultural practices.
Moments of Silence in Syria Place and Self in the State of Exception
Authors: AL-MAMOUN Ammar
Published: January 2025

This research discusses “silence” within the concept of “Necro politics” in the Syrian context, aiming to observe the conceptual “space” that silence refers to and create, along with its political and performative meanings, especially when violently imposed on individuals. We will examine the term “officers of silence” in artistic and literary works, as well as in forms of obedience and protest-oriented public performances, in an attempt to understand the “officers of silence” authority and their political impact. Our study adopts an intersectional approach that combines political theory with forms of daily performance, performative theory, and elements of performance art. We also use artistic and literary works from a “factographic” perspective to develop an understanding of methods for documenting reality within literary work. This approach seeks to address the crisis of archival absence in Syria, referred to as the “Kingdom of Silence” in the Middle East, where silence is imposed metaphorically, politically, and literally on individuals, with institutions contributing to its entrenchment and amplification.
Papel do Fator von Willebrand (vWF) e da Protease ADAMTS-13 em Distúrbios Hemorrágicos e Trombóticos: Implicações Clínicas em Neonatos com Doenças Oncológicas
Authors: Fuly Jaydes Schultz , Sá Romaryo Mareco Alves de , Machado Isadora Walber , Sousa Hellen Lorrany Barbosa de , Chiesa Guilherme Dalla , Rodrigues Yana Queiroz , Marchetti Júlia Muraro , Pissinatti Ana Livia Ferreira , Mubarac Nadyme Assef Athayde , Lopes Rafaela de Souza , Fernandes Marcos Roberto , Fávero Maria Eduarda Pereira Riberto
Published: January 2025

The study investigates the role of von Willebrand factor (vWF) and the protease ADAMTS-13 in hemostasis, with a focus on neonates with oncological diseases. This is an integrative literature review carried out in the Scopus, ScienceDirect and Embase databases. The results indicate that the interaction between vWF and ADAMTS-13 is essential for hemostatic balance, and its deregulation can lead to hemorrhagic and thrombotic complications in these patients. In cancer neonates, high levels of vWF and reduced ADAMTS-13 activity increase the risk of thrombosis, especially under inflammatory conditions or treatments such as chemotherapy. In addition, studies highlight the importance of monitoring these factors to prevent adverse events. It is concluded that understanding this relationship may contribute to more effective therapeutic strategies, reducing complications and improving the prognosis of neonates with câncer.
Enhancing Political Participation through Civic Education: Integrating Digital and Social Media for Peaceful Elections among Generation Z in Indonesia
Authors: Wijaya Mirza Mahbub , Amalia Hamsar Suci
Published: January 2025

Purpose –  This study investigates the role of civic education in shaping political participation among Generation Z in Indonesia, particularly in the context of peaceful elections. It aims to address the gap in understanding how the integration of digital and social media within civic education can empower young voters to engage constructively in the democratic process.
Methods/Design/Approach – The study employs a conceptual approach using Theory Synthesis to integrate fragmented theories and literature on civic education, youth political participation, and peaceful elections. The literature was selected based on specific criteria, ensuring relevance to the subject matter. Data were synthesized to create a cohesive theoretical framework that connects the role of civic education with the political engagement of Generation Z.
Findings – The study found that effective civic education, which integrates digital technology and social media, can significantly enhance Generation Z's political awareness and active participation. The findings suggest that current civic education curricula need to be updated to reflect the digital realities of Generation Z, thus improving the quality of their participation in elections and supporting a more peaceful democratic process.
Originality/Value – This research contributes to the field by proposing a more adaptive civic education model that aligns with the technological inclinations of Generation Z. It offers a novel perspective by highlighting the importance of social media as a tool for political learning and engagement, an area often overlooked in existing studies.
Practical Implications – The study underscores the need for educational policymakers to revise civic education curricula, incorporating digital and social media tools to better engage Generation Z. Implementing these changes could enhance the political literacy and participation of young voters, ultimately supporting more democratic and peaceful elections in Indonesia.
Keywords Civic education, generation Z, political participation, peaceful elections, digital integration
Paper type Conceptual paper
Evaluating Academic Service Quality at Universitas Sains Al-Qur’an Wonosobo: A SERVQUAL-Based Analysis of Student Satisfaction and Improvement Priorities
Authors: Fatmawati Ria , Murfi Ali
Published: January 2025

Purpose –  This study examines the quality of academic services at Universitas Sains Al-Qur’an (UNSIQ) Wonosobo, focusing on student satisfaction and identifying key service gaps based on the SERVQUAL model. The study aims to provide actionable recommendations for improving service quality by analyzing the gaps between student expectations and actual service delivery.
Methods/Design/Approach – A quantitative approach was adopted, using a survey distributed to 952 students across six faculties. The SERVQUAL model informed the design of the questionnaire, which measured the importance and satisfaction of academic services through a 5-point Likert scale. Importance-Performance Analysis (IPA) was applied to identify priority areas for improvement. Data validity and reliability were tested using SPSS.
Findings – Significant gaps were found in UNSIQ’s academic services, particularly in the Tangibles dimension, where the largest gap (1.71) was in internet access. Other dimensions such as Reliability and Responsiveness also showed noticeable gaps. The findings indicate the urgent need for improvement in digital infrastructure to enhance student satisfaction.
Originality/Value – This study adds to the literature on service quality in higher education by applying the SERVQUAL model in the context of an Indonesian university. The findings align with international studies on the importance of infrastructure and service quality in shaping student satisfaction and institutional loyalty. The study also provides actionable recommendations for UNSIQ, which can serve as a reference for similar institutions seeking to improve service quality.
Practical Implications – The research suggests that UNSIQ should prioritize enhancing both physical and digital infrastructure to better meet student expectations. Implementing regular feedback mechanisms could further align services with student needs, thereby increasing satisfaction and loyalty.
Keywords Academic service quality, student satisfaction, SERVQUAL, higher education, Importance-Performance Analysis (IPA)
Paper type Research paper
Influence of Leadership Competence, Achievement Motivation, and Organizational Learning Culture on Administrative Staff Performance at Universitas Gadjah Mada Graduate School
Authors: Tri Nugroho
Published: January 2025

Purpose –  This study aims to examine the factors influencing the performance of administrative staff at the Graduate School of Universitas Gadjah Mada (UGM). Specifically, the research focuses on the roles of leadership competence, achievement motivation, and organizational learning culture in determining staff performance, addressing gaps in previous studies that lacked a comprehensive integration of these factors.
Methods/Design/Approach – A quantitative approach with an explanatory survey design was employed. Data were collected using questionnaires distributed to all 89 administrative staff at the UGM Graduate School, yielding 78 valid responses. The relationships between leadership competence, achievement motivation, organizational learning culture, and performance were analyzed using multiple linear regression. Validity and reliability tests, alongside classical assumption tests, were conducted to ensure the robustness of the model.
Findings – The results demonstrate that both leadership competence and achievement motivation positively and significantly affect staff performance. Achievement motivation was identified as the most dominant factor, while organizational learning culture showed no significant influence. The model explains 57.2% of the variance in staff performance, indicating that other unexplored factors may contribute to performance outcomes.
Originality/Value – This study provides a novel integration of leadership competence, achievement motivation, and organizational learning culture within a single analytical model, contributing to the literature on human resource management in higher education in Indonesia. The findings offer a comprehensive understanding of key factors influencing staff performance in public higher education institutions.
Practical Implications – The findings suggest that higher education management should prioritize leadership development and motivation enhancement initiatives to improve staff performance. Although the organizational learning culture did not significantly affect performance, efforts should still be made to foster a learning environment to support long-term organizational success.
Keywords Leadership competence, achievement motivation, organizational learning culture, staff performance, higher education management
Paper type Research paper
FAKE NEWS E TSE
Authors: NONATO BRUNO AUGUSTO
Published: January 2025

O presente artigo discute o papel das resoluções expedidas pelo Tribunal Superior Eleitoral (TSE) no combate à desinformação. Para tanto, analisou-se qual a interpretação do tribunal acerca de fake news e como, com os mecanismos à disposição da Corte Eleitoral, foi combatida a disseminação de desinformação. Como resultado, observou- -se que o TSE adota recorrentemente “fatos sabidamente inverídicos” como sinônimo de fake news e que, por meio das resoluções, em face da omissão do legislativo em relação ao tema, buscou endurecer o combate à desinformação e responsabilizar as plataformas de redes sociais que permitem a veiculação de desinformação. Por fim, verificou- se que apesar de muito questionado, o poder regulamentar do TSE para expedir resoluções é fundamental para atualizar e dar execução ao Código Eleitoral e garantir não só a integridade do processo eleitoral, como a própria democracia.
Manajemen Penerimaan Siswa Baru Berbasis Online di Lembaga Pendidikan Islam
Authors: Cindy Cindy , Muhabibudin Nur , Ramdhani Ratna Dwi , Jarya Haenul , Akmaliah Qatrunnada Jinan , Dewi Nur Sartika
Published: January 2025

This research aims to explore and analyze the implementation of online-based new student admissions management in Islamic educational institutions. The problems identified include challenges in the new student admissions process, the effectiveness of the online system, and stakeholder perceptions of the use of technology in admissions management. The research method used is a case study with a qualitative approach, involving in-depth interviews with admissions managers, administrative staff, and prospective students. The research results show that the online system has provided efficiency in the admission process, but still faces several technical obstacles and resistance from several stakeholders. In addition, it was found that technology-related training and effective communication could increase acceptance of the new system. In conclusion, online-based new student admissions management offers the potential to increase efficiency and accessibility, but requires appropriate adjustments and strong support from all relevant parties
Peran Pendidikan Islam dalam Membentuk Nilai Moral Remaja di SMP Budi Luhur Mandiri Sangatta Utara
Authors: Ramdhani Ratna Dwi , Yasin Muhammad
Published: January 2025

Islamic education greatly influences the morals and character of teenagers, especially through the spread of religious values ​​that are applied in everyday life. The focus of this research is to see the role of Islamic education as an agent of socialization in forming moral values ​​among teenagers and how teenagers view the role of Islamic education in forming their moral values ​​at Budi Luhur Mandiri Sangatta Utara Middle School. The aim of the research is to see the role of Islamic education as an agent of socialization in forming moral values ​​among teenagers, and to find out teenagers' views on the role of Islamic education in shaping their moral values ​​at Budi Luhur Mandiri Sangatta Utara Middle School. This research uses qualitative methods with a descriptive type. To collect data, researchers used interviews, observation and documentation. The research results show that spiritual and religious programs such as "29 Noble Characters" and "6 Luhur Thobiats", which instill moral values ​​among students at SMP Budi Luhur Mandiri Sangatta Utara, have worked well in socializing moral values ​​among students. teenager. Researchers found that Islamic education at Budi Luhur Mandiri Middle School has played an important role in shaping student morality, both through school culture and habits and the application of Islamic values ​​in everyday life. Meanwhile, teenagers' perceptions regarding how Islamic education shapes their moral values ​​are very positive. They also say that Islamic education builds students' morals at home, in the community, and at school. Islamic education can help change the character of teenagers if implemented correctly. Therefore, it is important for educators to continue to develop interesting and relevant teaching approaches so that teenagers are interested and involved in the learning process.
Peran Pendidikan Islam Dalam Mendorong Perubahan Sosial Di SMA Plus Budi Luhur Mandiri
Authors: Jarya Haenul , Yasin Muhammad
Published: January 2025

This study examines the role of Islamic education in driving social change at SMA Plus Budi Luhur Mandiri. The research aims to identify the contributions of Islamic education to character development, social awareness, and student participation in social change within the school and community. A qualitative approach with a phenomenological design was employed. Data were collected through interviews, observations, and documentation, then analyzed using Miles and Huberman's interactive model. The findings reveal that Islamic education shapes students' discipline, responsibility, and politeness; enhances social awareness through empathy teaching; and fosters student involvement in social activities such as community service. Islamic education is proven to be not only a means of knowledge transfer but also an effective tool for creating positive social change.
Intermedial Encounters in Experimental Cinema: The Body as Performance Space1
Authors: Kostopoulou Loukia , Katsaridou Maria Ilia
Published: January 2025

This article sets out to investigate intermediality in experimental cinema. It explores the intermedial crossings of dance, music, and cinema and how such crossovers recondition the medium of cinema and its impact on the spectator. According to Pethö, exploring intermediality through an affective lens means looking into the “folding together of sensory experiences of different arts” (2023). Thus, the spectator is led through an enhanced experience and is gradually affected at a sensory level. This article analyzes intermedial crossovers in a short film entitled Ghosts ((LA) HORDE, 2022). The film features instances of stillness and motion and offers a diversified experience to the spectator—one which resembles a music video or dance performance one moment and a theatrical performance the next.
Editorial Mosaic: 202 – Modern Web
Authors: Córcoles César
Published: January 2025

Este 2025, hace diez años que Mosaic es el hogar en la web de un pequeño evento sobre diseño y desarrollo web, el Modern Web Event. En esos diez años, hemos intentado hacer difusión de todo lo que rodea al diseño y al desarrollo web, uno de los focos en torno a los que gira la multimedia que ha sido siempre el motor que ha alimentado esta revista. Y con ocasión de estos diez años, hemos considerado que sería un buen momento para echar la vista atrás, recapacitar y recuperar algunos de los temas que nos han parecido más interesantes. No hemos podido tocar todos los que nos habría gustado, pero sí creemos que los artículos que recogemos en este número son dignos de aparecer en él. Todos menos uno, además, han sido escritos por ponentes que hemos tenido en el Modern Web en alguna ocasión estos últimos diez años.
Introduction to Social-Emotional Learning in English Language Education: Mapping the Landscape and Reflecting on the Way Forward
Authors: Pentón Herrera Luis Javier
Published: January 2025

Introduction
An Emotionally Intelligent, Ecolinguistic Approach to Content and Language Integrated Learning
Authors: Rutledge Edward , Manegre Marni
Published: January 2025

This article examines the incorporation of concepts derived from ecolinguistics and social-emotional learning (SEL) into the content and language integrated learning (CLIL) methodology when teaching about climate change in the second language classroom. A test of this approach was implemented during a teaching practicum with 14- and 15-year-old students in Catalonia to survey their beliefs, attitudes, and knowledge of the topic before and after experiencing content-based lessons on climate change. Findings suggest that such an approach may be effective, if not essential, for fostering communicative competence, subject matter learning, and social-emotional resilience when presenting challenging existential issues in the classroom.
Elevating the Antagonist Encounter: How the ‘Stitch’ Transforms Victimhood Contestation on TikTok
Authors: Geboers Marloes , Hammelburg Esther
Published: January 2025

Working as speech acts that delineate online communities, claims to victimhood tend to evoke contestation. Their inherent political nature spurs user engagement in the shape of clicks, shares, emojis, and so on. TikTok’s multimodality has given rise to new practices of engagement that significantly shape how victimhood is communicated and negotiated. This study draws attention to the platform vernacular practice of the ‘stitch.’ Allowing users to respond to someone else by ‘remixing’ social media content of others, the stitch is a platform practice designed for commentary. We zoom in on stitched videos networked by hashtags, published in relation to the Israel-Hamas war. TikTok’s multimodality expands user pathways that connect claimants and those who contest them. Moving beyond hashtag hijacking the stitch elevates a practice of commentary that turns victimhood politics into a spectacle that politicizes formerly less political realms, and that further blurs the boundaries between on- and offline spaces. The analysis shows how stitched videos are especially used for antagonist encounters where they crowd out the ‘original’ post to which they respond. In this way, stitches can be seen as tools that aid platformed ‘regimes’ of visibility that prioritize the antagonist encounter in order to commodify them.
Teaching for a Broken World
Authors: Chakravorty Spivak Gayatri
Published: January 2025

This essay offers methodological suggestions for using the humanities to create a general will for social justice. The enthusiasm of the initial years will naturally cool. We must continue to try to keep to the initial principles, even as we satisfy institutional norms. In restoring the ethical base of society through humanities teaching – teaching the other-directed practice of learning rather than keeping track of the production of knowledge – we remind the corporate university that the restoration of juridico-ethics to society cannot be sacrificed in the name of revenue-production. The model of a new International where the classroom is the locus of the production of individuated collectivities is proposed. The imperatives of planetarity are touched on. Activist reading is seen as a relay race. We are reminded that every self-declared rupture is also an unacknowledged repetition. All this to be undertaken globally by using the already-existing model of the international civil society.
Towards Symbiocene: Simulation and Extrapolation of Environmental Inevitability in Ecofiction
Authors: Agarwal Pooja
Published: January 2025

Anthropogenic intervention into the environment has led us towards what is now widely understood as a new epoch: the Anthropocene. While nature is a concrete and palpable entity, the othering of it is a linguistic construct. Literary narratives are significant part of our everyday discourse and their efficacy in positing an alternative worldview cannot be undermined. The current paper seeks to investigate select texts of ecofiction: Megan Hunter’s The End We Start from (2017), Jim Laughter’s Polar City Red (2012), Louis Lowry’s The Giver (1993), and Ernest Callenbach’s Ecotopia (1975), towards analyzing how ecofiction can foster global eco-consciousness (Wallis 2013) by either instilling a sense of eco-guilt (Agoston et al. 2022) or offering ecological hope (Northcott 2020). Towards that end, the paper shall trace out the genesis of ecofiction, and consider how through the twin techniques of estrangement and extrapolation, it creates alternate worlds, thereby simulating future scenarios. These scenarios can offer apocalyptic visions of dismal and tragic consequences of the human intervention into the environment, or could posit a rejuvenating alteration in human efforts, resulting in increased environmental imagination, leading us from Anthropocene towards the Symbiocene (Albrecht 2015).
The Society of Remote Control: AI and Other Intelligences
Authors: Tambling Jeremy
Published: January 2025

The paper reads the power of social media, especially Artificial Intelligence, in the light of Foucault, and Benjamin, and, especially, Deleuze, on the society of control, as he calls it: to which this paper adds the word “remote” since this quality is even more pertinent to the present-day than Foucault’s idea of the classical Panopticon. It examines different senses of the word “intelligence,” drawing on Catherine Malabou to underscore the idea of the brain’s “plasticity,” something ignored when the brain, and its contents, and communication, are treated as so much “data.” It concludes by asking what role AI might have in the humanities.
Integration of ATAC and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation
Authors: Petratou Kleio , Stehling Martin , Müller Ferenc , Schulte-Merker Stefan
Published: January 2025

Two types of osteoblasts are required to assemble the zebrafish embryonic skeleton: classical osteoblasts homologous to the mammalian cell, and notochord sheath cells, which serve as non-classical osteoblasts. The gene
entpd5a
is critically required for ossification via both types of osteoblasts. Despite the indispensability of zebrafish models in vertebrate research, the genetic regulation of bone formation, as well as mechanisms of transcriptional control of
entpd5a
, remain largely unknown. Here, using a newly generated transgenic line, we isolate classical and non-classical osteoblasts from zebrafish embryos and performed both ATAC-seq and RNA-seq. We analysed results independently and integratively to understand those chromatin dynamics and accompanying transcriptomic changes that occur in different skeletal cell types. We show that although Dlx family factors are playing important roles in classical osteoblast regulation, Hox family factors are involved in governing spinal ossification via non-classical osteoblasts. We further present a resource-driven analysis of the
entpd5a
promoter, experimentally validating the ATAC-seq dataset and proposing mechanisms of regulating the complex
entpd5a
expression pattern during zebrafish osteogenesis. Our results thus provide a necessary comprehensive resource for the field of bone development and indicate spatio-temporally regulated promoter/enhancer interactions taking place in the
entpd5a
locus.
ALL-Net: integrating CNN and explainable-AI for enhanced diagnosis and interpretation of acute lymphoblastic leukemia
Authors: Thiriveedhi Abhiram , Ghanta Swetha , Biswas Sujit , Pradhan Ashok K.
Published: January 2025

This article presents a new model, ALL-Net, for the detection of acute lymphoblastic leukemia (ALL) using a custom convolutional neural network (CNN) architecture and explainable Artificial Intelligence (XAI). A dataset consisting of 3,256 peripheral blood smear (PBS) images belonging to four classes—benign (hematogones), and the other three Early B, Pre-B, and Pro-B, which are subtypes of ALL, are utilized for training and evaluation. The ALL-Net CNN is initially designed and trained on the PBS image dataset, achieving an impressive test accuracy of 97.85%. However, data augmentation techniques are applied to augment the benign class and address the class imbalance challenge. The augmented dataset is then used to retrain the ALL-Net, resulting in a notable improvement in test accuracy, reaching 99.32%. Along with accuracy, we have considered other evaluation metrics and the results illustrate the potential of ALLNet with an average precision of 99.35%, recall of 99.33%, and F1 score of 99.58%. Additionally, XAI techniques, specifically the Local Interpretable Model-Agnostic Explanations (LIME) algorithm is employed to interpret the model’s predictions, providing insights into the decision-making process of our ALL-Net CNN. These findings highlight the effectiveness of CNNs in accurately detecting ALL from PBS images and emphasize the importance of addressing data imbalance issues through appropriate preprocessing techniques at the same time demonstrating the usage of XAI in solving the black box approach of the deep learning models. The proposed ALL-Net outperformed EfficientNet, MobileNetV3, VGG-19, Xception, InceptionV3, ResNet50V2, VGG-16, and NASNetLarge except for DenseNet201 with a slight variation of 0.5%. Nevertheless, our ALL-Net model is much less complex than DenseNet201, allowing it to provide faster results. This highlights the need for a more customized and streamlined model, such as ALL-Net, specifically designed for ALL classification. The entire source code of our proposed CNN is publicly available at https://github.com/Abhiram014/ALL-Net-Detection-of-ALL-using-CNN-and-XAI.
Serum salusin levels in diarrhea- and constipation-predominant irritable bowel syndrome
Authors: Tuncel Elif Tugba , Ozcan Seda Sabah , Korkmaz Mehmet , Börekci Elif
Published: January 2025

Objective

Inflammation and immunity play major roles in the etiopathogenesis of functional intestinal disorders. The salusins that were identified in this study are important because of their ease of collection, sensitivity and reliability. For that reason, the aim of this study was to analyze the importance of the levels of salusin in the blood, an inflammation-related parameter, in the diagnosis and prediction of irritable bowel disease.

Methodology

The study participants included 28 diagnosed with constipation-predominant IBS, 29 (34.1%) diagnosed with diarrhea-predominant IBS (D-IBS), and 28 (32.9%) controls. Enzyme-linked immune-sorbent assay (ELISA) method has been used for the measurement of salusin levels.

Results

Participants were 50 (58.8%) female and 35 (41.2%) male. The serum levels of salusin-α were substantially reduced in the diarrhea-predominant IBS group vs controls. There was also no major difference in the levels of salusin between the constipation-predominant-IBS and the diarrhea-predominant IBS group.

Conclusion

A major prognostic relationship was found between the level of salusins and the subgroup of D-IBS. It is well known that salusins have been related to inflammatory processes and oxidative injury in previous studies. The relationship between salusin and gastrointestinal diseases should be further investigated. Low-grade submucosal intestinal inflammation is also associated with irritable bowel syndrome. It is our belief that salusins may be useful in diagnosing, predicting or treating IBS.
Life expectancy of cats in Britain: moggies and mollies live longer
Authors: Mata Fernando
Published: January 2025

The domestic cat (Felis catus) has been a popular companion animal for about 12,000 years, initially valued for rodent control before evolving into pets that provide affection and companionship. Unlike dogs, cats were not selectively bred for specific roles until the late 1800s, resulting in breeds defined primarily by appearance, which sometimes leads to genetic disorders. Modern animal welfare concerns emphasize longevity and health, prompting research into factors affecting cat lifespans, including sex, reproductive status, and breed. This study aims to expand on previous UK research by analyzing these interactions and highlighting the potential negative impacts of pure breeding on cat health. Data from 7,708 cats receiving veterinary care in the UK during 2019 were analyzed, focusing on reproductive status, breeding status, age at death, and sex. Data were analyzed using ANOVA and Cox proportional hazards models to assess survival differences. The overall mean lifespan of cats in the UK is 11.83 years. Analysis indicates that male cats live shorter lives than females, attributed to higher trauma rates and health issues among males. Neutered/spayed cats generally exhibit longer lifespans compared to entire cats. Tom cats have the shortest lifespan, while spayed females (mollies) live the longest. Moggies tend to outlive both pure and cross-bred cats, suggesting that genetic diversity may contribute to greater longevity. The results of this study emphasize the influence of sex, reproductive status, and cat type on feline lifespan, highlighting the need for targeted health interventions, particularly for male cats. The findings underscore the complex interplay of genetic and environmental factors in determining the health and longevity of domestic cats. This research not only contributes to existing knowledge but also advocates for the consideration of these variables in future studies and veterinary practices.
Sine-Ishita Distribution: Properties and Applications to Survival Data
Authors: Yakubu Nasiru , Adamu Abubakar , Ahmadu Abubakar Norndigi , Akinrefon Adesupo Adeoye
Published: January 2025

This paper presents a novel extension of the Ishita distribution called “sine-Ishita distribution”. The Sine-G family was used to derive the proposed sine-Ishita distribution. The research investigates some properties of the sine-Ishita distribution such as the moments, moments generating function, characteristics function, survival and hazard functions as well as distribution of order statistics. The research also estimates the parameter of the proposed distribution using the method of maximum likelihood. The research illustrated the usefulness of the proposed distribution by applications to four real life datasets and the results show that the proposed distribution fits the data better compared to the other five distributions considered in the study. This performance is an indication that the sine-Ishita distribution can be used for modelling real life event arising from many areas of life.
Cardiovascular Risks of Trenbolone Abuse: Emerging Evidence
Authors: Câmara Lucas Caseri , Viana Diogo Pinto
Published: January 2025

The “Type of Article” of this paper is “Letter to the Editor”. This paper discuses about: “Cardiovascular Risks of Trenbolone Abuse: Emerging Evidence”. No formal abstract is available. Readers are requested to read the full article.
Innovative Regulation of Open Source Intelligence and Deepfakes AI in Managing Public Trust
Authors: Obioha-Val Onyinye Agatha , Gbadebo Michael Olayinka , Olaniyi Oluwaseun Oladeji , Chinye Noah Chukwufumnanya , Balogun Adebayo Yusuf
Published: January 2025

This study investigates the regulatory and ethical dimensions of Open Source Intelligence (OSINT) and deepfake technologies, analyzing their impact on public trust, privacy, and societal stability. Using data from the Global Dataset of Events, Location, and Tone (GDELT), sentiment analysis and time-series regression identified a significant decline in public sentiment (β = -0.23, p = 0.01) and societal stability due to deepfake incidents and OSINT misuse. The Deepfake Detection Challenge Dataset (DFDC) was analyzed using machine learning models, with neural networks achieving the highest accuracy (92%) and precision (91%). Regulatory frameworks were evaluated using the OECD database, where enforcement capacity demonstrated the strongest impact on reducing misuse cases (β = -0.42, p = 0.002). Recommendations include the establishment of globally coordinated regulatory frameworks, public awareness campaigns, investment in advanced detection systems, and ethical integration of AI into OSINT practices.
Drought Assessment in Kalaburgi District, North-eastern Dry Zone of Karnataka, India by Using Remote Sensing and Google Earth Engine
Authors: Manjunatha M. K. , Babu B. Maheshwara , Reddy G. V. Srinivasa , Satishkumar U. , Ajayakumar M. Y. , Kumar G. Manoj
Published: January 2025

Drought is a significant natural disaster exacerbated by global warming, leading to severe environmental, economic and societal impacts. As one of the most complex phenomena, drought requires advanced methods for effective monitoring and assessment. Remote sensing indices have proven effective in analyzing drought's geographical and temporal distribution. In this study, the semi-arid nature of the North-Eastern Dry Zone of Karnataka, characterized by low rainfall and high temperature, was examined for its vulnerability to drought. The Google Earth Engine (GEE) platform was utilized, which provides cloud-based access to advanced computational resources for processing multi-temporal satellite data. This approach minimizes the need for extensive data downloads and complex software operations, enabling efficient drought monitoring. In this study, GEE was applied to create and execute customized scripts for drought assessment, thereby accelerating the procedure and minimizing the need for extensive data downloads and complex software operations. The study focused on the North Eastern Dry Zone of Karnataka, particularly Kalaburgi district, employing the Normalized Difference Vegetation Index (NDVI) and Vegetation Condition Index (VCI) derived from MODIS data. The analysis revealed severe drought conditions, particularly in 2001, with NDVI values as low as 0.07 at Afzalpur station and 0.06 at Chitapur station, indicating significant vegetation stress. The VCI analysis further supported these findings, with values as low as 0.05 at Afzalpur station and 0.03 at Chitapur station, highlighting the drought's intensity. This integrated approach provides a reliable evaluation of agricultural drought, essential for enhancing drought management and mitigation strategies in the region.
Effect of Headgear on Physiological, Physical Response of Male Farm Worker Under Heat Stress Condition
Authors: Patil Prithviraj , Mehta A. K. , Mane Omkar , Dhumal Shiwani , Palve Sukanya , Patil Tejaswini
Published: January 2025

India has a vast geographical area with variations in climate and temperature from region to region. Summers are very harsh in many parts of the country where   temperature exceeds 45°C. Most of the agricultural operations in the country are performed by manual labour in such a warm climate where it becomes difficult for the body to maintain its heat balance with the environment. In leads to heat stress many a time. Heat stress causes many heat disorders like systemic disorder, heat syncope, heat odema, heat cramp, heat exhaustion and heat stroke. To minimize heat stress in warm climate many techniques are used. One of them is the use of headgear which protects the head. Farmers are using towel, pagadi, caps etc. as headgear from the last many years. The independent parameters of the study were WBGT (28, 30 and 32oC), headgears (Bamboo hat, felt hat with 90 mm brim width, white pagdi and solar hat) and subject (10 male farm workers). The dependent parameters of study were heart rate, oxygen consumption rate and overall discomfort rating. The results of the research showed that use of headgear reduced the effect of heat stress significantly on physiological parameters and physical discomfort parameters.
Ruxolitinib for Refractory PL-12 Antisynthetase Syndrome–Associated Angioedema-Like Panniculitis With Clonal T-Cell Receptor Gene Rearrangement
Authors: Sengupta Srona , Law Brandon , Sennett Rachel , Jedrych Jaroslaw J. , Albayda Jemima , Kang Jun K.
Published: December 2023

This case report describes a woman in her 30s who presented with a 3-year history of anti–PL-12 antisynthetase syndrome characterized by interstitial lung disease, arthritis, and myositis and was diagnosed with antisynthetase syndrome–associated panniculitis.
Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Retinopathy in Patients With Type 2 Diabetes
Authors: Yen Fu-Shun , Wei James Cheng-Chung , Yu Teng-Shun , Hung Yu-Tung , Hsu Chih-Cheng , Hwu Chii-Min
Published: December 2023

Importance

Diabetic nephropathy and diabetic retinopathy share many similarities in pathophysiological processes. Preclinical studies have shown that sodium-glucose cotransporter 2 inhibitors (SGLT2is) have a protective role in the risk of diabetic retinopathy.

Objective

To compare the risk of sight-threatening retinopathy associated with SGLT2is and other second-line glucose-lowering medications (including pioglitazone, sulfonylureas, and dipeptidyl peptidase-4 inhibitors [DPP-4is]) in patients with type 2 diabetes (T2D).

Design, Setting, and Participants

This cohort study in Taiwan applied a new-user and active-comparator design. Patient demographic and clinical data were obtained from the National Health Insurance Research Database. Adult patients with newly diagnosed T2D from January 1, 2009, to December 31, 2019, were recruited and followed up until December 31, 2020. Propensity score matching was used to identify pairs of patients treated with SGLT2i vs DPP-4i, SGLT2i vs pioglitazone, and SGLT2i vs sulfonylurea from January 1, 2016, to December 31, 2019. Data were analyzed between August 18, 2022, and May 5, 2023.

Exposures

Treatment with SGLT2i, DPP-4i, pioglitazone, and sulfonylureas starting on January 1, 2016.

Main Outcomes and Measures

The main outcome was sight-threatening retinopathy in participants. Cox proportional hazards regression models were used to assess relative hazards of sight-threatening retinopathy between the matched case and control groups.

Results

A total of 3 544 383 patients with newly diagnosed T2D were identified. After 1:1 propensity score matching, 65 930 pairs of patients treated with SGLT2i vs DPP-4i, 93 760 pairs treated with SGLT2i vs pioglitazone, and 42 121 pairs treated with SGLT2i vs sulfonylurea were identified. These matched patients included 236 574 males (58.6%), with a mean (SD) age of 56.9 (11.8) years. In the matched cohorts, SGLT2i had a significantly lower risk of sight-threatening retinopathy than DPP-4i (adjusted hazard ratio [AHR], 0.57; 95% CI, 0.51-0.63), pioglitazone (AHR, 0.75; 95% CI, 0.69-0.81), and sulfonylureas (AHR, 0.62; 95% CI, 0.53-0.71). The Kaplan-Meier curves showed that SGLT2i was associated with a significantly lower cumulative incidence of sight-threatening retinopathy than DPP-4i (3.52 vs 6.13; P < .001), pioglitazone (4.32 vs 5.76; P < .001), and sulfonylureas (2.94 vs 4.67; P < .001).

Conclusions and Relevance

This cohort study found that SGLT2i was associated with a lower risk of sight-threatening retinopathy compared with DPP-4i, pioglitazone, and sulfonylureas. This finding suggests that SGLT2i may play a role not only in reduced risk of diabetic nephropathy but also in the slow progression of diabetic retinopathy in patients with T2D.
Synthetic Polymers
Authors: Skoglund Robert , Roy Robert , Cavender Finis L.
Published: December 2023

The global annual production of plastic is approaching a half‐billion tonnes and two families of synthetic polymers, polyethylene and polypropylene, account for approximately 45% of this production. The most common applications for synthetic polymers are in packaging and consumer/household goods and they are often referred to as single‐use plastics. However, other applications for synthetic polymers include medical/medical device, construction, agriculture, automotive, and industrial uses. Exposure to monomers, polymers, resins, and plastics can occur during the initial polymerization and manufacturing of the resins, the subsequent polymerization and manufacturing of the plastics and finished products, during use of the finished product, and during the product's end‐of‐life stage. This chapter focuses on understanding and mediating the toxicological issues with synthetic polymers in the workplace, including the production of the polymers, the resins, and the finished plastic products. In addition to the toxicology profiles, this chapter discusses production and uses, potential exposures, hazard classification, thermo‐decomposition products, sensitive applications such as food‐contact and medical applications, and exposure guidelines. The environmental impact of these synthetic polymers can be significant, so this chapter also touches on the life cycle of these polymers including recycled and bio‐based feedstocks, carbon emissions, macroplastic and microplastic pollution, degradation in the environment, additives, and end‐of‐life scenarios.