bluuebunny/crossref_metadata_2025 huggingface dataset:
Emotion-Attention Interaction in the Right Hemisphere
Authors: Hartikainen Kaisa M.
Published: July 2021

Hemispheric asymmetries in affective and cognitive functions have been extensively studied. While both cerebral hemispheres contribute to most affective and cognitive processes, neuroscientific literature and neuropsychological evidence support an overall right hemispheric dominance for emotion, attention and arousal. Emotional stimuli, especially those with survival value such as threat, tend to be prioritized in attentional resource competition. Arousing unpleasant emotional stimuli have prioritized access, especially to right-lateralized attention networks. Interference of task performance may be observed when limited resources are exhausted by task- and emotion-related processing. Tasks that rely on right hemisphere-dependent processing, like attending to the left visual hemifield or global-level visual features, are especially vulnerable to interference due to attention capture by unpleasant emotional stimuli. The aim of this review is to present literature regarding the special role of the right hemisphere in affective and attentional brain processes and their interaction. Furthermore, clinical and technological implications of this interaction will be presented. Initially, the effects of focal right hemisphere lesion or atrophy on emotional functions will be introduced. Neurological right hemisphere syndromes including aprosodia, anosognosia and neglect, which further point to the predominance of the intact right hemisphere in emotion, attention and arousal will be presented. Then there will be a brief review of electrophysiological evidence, as well as evidence from patients with neglect that support attention capture by emotional stimuli in the right hemisphere. Subsequently, experimental work on the interaction of emotion, attention and cognition in the right hemispheres of healthy subjects will be presented. Finally, clinical implications for better understanding and assessment of alterations in emotion–attention interaction due to brain disorder or treatment, such as neuromodulation, that impact affective brain functions will be discussed. It will be suggested that measuring right hemispheric emotion–attention interactions may provide basis for novel biomarkers of brain health. Such biomarkers allow for improved diagnostics in brain damage and disorders and optimized treatments. To conclude, future technological applications will be outlined regarding brain physiology-based measures that reflect engagement of the right hemisphere in affective and attentional processes.
Applied Element Modelling of Warping Effects in Thin-Walled C-Shaped Steel Sections
Authors: Gabbianelli Giammaria
Published: July 2021

The Applied Element Method (AEM) is a relatively recent numerical technique, originally conceived for simulating the large displacement nonlinear response of reinforced concrete, masonry and steel structures, and successful applications have been presented by various researchers. Recently, AEM was used to model the mechanical behaviour of steel storage pallet racks, i.e., particular cold-formed steel structures typically employed for storing goods and materials. Such systems are often subjected to peculiar displacements and stresses due to warping effects, which are inherent and often govern their behaviour, increasing the peak strength and ultimate displacement demand. This phenomenon has not been studied through AEM yet; hence, this work investigates the capabilities of AEM in simulating the warping effects in typical steel rack members, i.e., thin-walled C-shaped sections. Preliminary results and comparison against established modelling approaches indicate that AEM can accurately simulate this phenomenon, both in terms of displacements and stresses.
Treatment Patterns, Clinical Outcomes and Healthcare Costs of Advanced Non-Small Cell Lung Cancer: A Real-World Evaluation in Italy
Authors: Franchi Matteo , Cortinovis Diego , Corrao Giovanni
Published: July 2021

We aimed at describing treatment pathways, clinical outcomes and healthcare costs of advanced non-small cell lung cancer (NSCLC) patients in Lombardy Region, Italy. Using healthcare administrative data, 37,562 patients with a new diagnosis of lung cancer between 2012 and 2019 were identified. Among these, patients who started a first-line treatment for advanced NSCLC with either pembrolizumab (n = 660) or tyrosine-kinase inhibitors (TKI) (n = 1245) before 30 June 2020 were included in the study cohort and followed-up until 31 December 2020. Among pembrolizumab users, median time-to-treatment failure (TTF) and median overall survival (OS) were 3.2 months and 13.6 months, respectively. About one third (34.1%) switched to second-line treatment (chemotherapy for all of them). Among TKI users, median TTF and median OS were 9.3 months and 18.4 months, respectively, and 37.1% of patients started second-line treatment (17.8% with TKI and 19.2% with chemotherapy). Average per-patient cumulative healthcare costs during the first year after first-line treatment start were 51,735 € and 30,708 €, respectively, in pembrolizumab and TKI first-line users. These results are coherent with those reported from other real--world studies and may help both clinicians and health decision makers.
Risk Factors for Liver Decompensation and HCC in HCV-Cirrhotic Patients after DAAs: A Multicenter Prospective Study
Authors: Morisco Filomena , Federico Alessandro , Marignani Massimo , Cannavò Mariarita , Pontillo Giuseppina , Guarino Maria , Dallio Marcello , Begini Paola , Benigno Rosa G. , Lombardo Flavia L. , Stroffolini Tommaso
Published: July 2021

Background: Prospective studies on predictors of liver-related events in cirrhotic subjects achieving SVR after DAAs are lacking. Methods: We prospectively enrolled HCV cirrhotic patients in four Italian centers between November 2015 and October 2017. SVR and no-SVR cases were compared according to the presence or absence of liver-related events during a 24-month follow-up. Independent predictors of liver-related events were evaluated by Cox regression analysis. Results: A total of 706 subjects started DAAs therapy. SVR was confirmed in 687 (97.3%). A total of 61 subjects (8.9%) in the SVR group and 5 (26.3%) in the no-SVR group had liver-related events (p < 0.03). The incidence rate x 100 p/y was 1.6 for HCC, 1.7 for any liver decompensation, and 0.5 for hepatic death. Baseline liver stiffness (LSM) ≥ 20 kPa (HR 4.0; 95% CI 1.1–14.1) and genotype different from 1 (HR 7.5; 95% CI 2.1–27.3) were both independent predictors of liver decompensation. Baseline LSM > 20 KPa (HR 7.2; 95% CI 1.9–26.7) was the sole independent predictor of HCC. A decrease in liver stiffness (Delta LSM) by at least 20% at the end of follow-up was not associated with a decreased risk of liver-related events. Conclusion: Baseline LSM ≥ 20 kPa identifies HCV cirrhotic subjects at higher risk of liver-related events after SVR.
A Yes-Associated Protein (YAP) and Insulin-Like Growth Factor 1 Receptor (IGF-1R) Signaling Loop Is Involved in Sorafenib Resistance in Hepatocellular Carcinoma
Authors: Ngo Mai-Huong T. , Peng Sue-Wei , Kuo Yung-Che , Lin Chun-Yen , Wu Ming-Heng , Chuang Chia-Hsien , Kao Cheng-Xiang , Jeng Han-Yin , Lin Gee-Way , Ling Thai-Yen , Chang Te-Sheng , Huang Yen-Hua
Published: July 2021

The role of a YAP-IGF-1R signaling loop in HCC resistance to sorafenib remains unknown. Method: Sorafenib-resistant cells were generated by treating naïve cells (HepG2215 and Hep3B) with sorafenib. Different cancer cell lines from databases were analyzed through the ONCOMINE web server. BIOSTORM–LIHC patient tissues (46 nonresponders and 21 responders to sorafenib) were used to compare YAP mRNA levels. The HepG2215_R-derived xenograft in SCID mice was used as an in vivo model. HCC tissues from a patient with sorafenib failure were used to examine differences in YAP and IGF-R signaling. Results: Positive associations exist among the levels of YAP, IGF-1R, and EMT markers in HCC tissues and the levels of these proteins increased with sorafenib failure, with a trend of tumor-margin distribution in vivo. Blocking YAP downregulated IGF-1R signaling-related proteins, while IGF-1/2 treatment enhanced the nuclear translocation of YAP in HCC cells through PI3K-mTOR regulation. The combination of YAP-specific inhibitor verteporfin (VP) and sorafenib effectively decreased cell viability in a synergistic manner, evidenced by the combination index (CI). Conclusion: A YAP-IGF-1R signaling loop may play a role in HCC sorafenib resistance and could provide novel potential targets for combination therapy with sorafenib to overcome drug resistance in HCC.
A Novel ZIP4-HDAC4-VEGFA Axis in High-Grade Serous Ovarian Cancer
Authors: Fan Qipeng , Li Lihong , Wang Tian-Li , Emerson Robert E. , Xu Yan
Published: July 2021

We have recently identified ZIP4 as a novel cancer stem cell (CSC) marker in high-grade serous ovarian cancer (HGSOC). While it converts drug-resistance to cisplatin (CDDP), we unexpectedly found that ZIP4 induced sensitization of HGSOC cells to histone deacetylase inhibitors (HDACis). Mechanistically, ZIP4 selectively upregulated HDAC IIa HDACs, with little or no effect on HDACs in other classes. HDAC4 knockdown (KD) and LMK-235 inhibited spheroid formation in vitro and tumorigenesis in vivo, with hypoxia inducible factor-1 alpha (HIF1α) and endothelial growth factor A (VEGFA) as functional downstream mediators of HDAC4. Moreover, we found that ZIP4, HDAC4, and HIF1α were involved in regulating secreted VEGFA in HGSOC cells. Furthermore, we tested our hypothesis that co-targeting CSC via the ZIP4-HDAC4 axis and non-CSC using CDDP is necessary and highly effective by comparing the effects of ZIP4-knockout/KD, HDAC4-KD, and HDACis, in the presence or absence of CDDP on tumorigenesis in mouse models. Our results showed that the co-targeting strategy was highly effective. Finally, data from human HGSOC tissues showed that ZIP4 and HDAC4 were upregulated in a subset of recurrent tumors, justifying the clinical relevance of the study. In summary, our study provides a new mechanistic-based targeting strategy for HGSOC.
Selective 5-Hydroxymethylfurfural Hydrogenolysis to 2,5-Dimethylfuran over Bimetallic Pt-FeOx/AC Catalysts
Authors: Xin Yongjie , Li Sichan , Wang Haiyong , Chen Lungang , Li Shuang , Liu Qiying
Published: July 2021

The selective hydrogenolysis of 5-hydroxymethylfurfural (HMF) platform molecule to 2,5-dimethylfuran (DMF) has attracted increasing attention due to its broad range of applications. However, HMF, with multiple functional groups, produces various byproducts, hindering its use on an industrial scale. Herein, a bimetallic Pt-FeOx/AC catalyst with low Pt and FeOx loadings for selective HMF hydrogenolysis to DMF was prepared by incipient wetness impregnation. The structures and properties of different catalysts were characterized by XRD, XPS, TEM, ICP-OES and Py-FTIR techniques. The addition of FeOx enhanced Pt dispersion and the Lewis acidic site density of the catalysts, and was found to be able to inhibit C=C hydrogenation, thereby im-proving DMF yield. Moreover, the presence of Pt promoted the reduction of iron oxide, creating a strong interaction between Pt and FeOx. This synergistic effect originated from the activation of the C–O bond over FeOx species followed by hydrogenolysis over the adjacent Pt, and played a critical role in hydrogenolysis of HMF to DMF, achieving a yield of 91% under optimal reaction conditions. However, the leaching of Fe species caused a metal–acid imbalance, which led to an increase in ring hydrogenation products.
The Pathway towards Photoelectrocatalytic Water Disinfection: Review and Prospects of a Powerful Sustainable Tool
Authors: Garcia-Segura Sergi , Arotiba Omotayo A. , Brillas Enric
Published: July 2021

Photoelectrocatalysis is a hybrid photon/electron-driven process that benefits from the synergistic effects of both processes to enhance and stabilize the generation of disinfecting oxidants. Photoelectrocatalysis is an easy to operate technology that can be scaled-up or scaled-down for various water treatment applications as low-cost decentralized systems. This review article describes the fundamentals of photoelectrocatalysis, applied to water disinfection to ensure access to clean water for all as a sustainable development goal. Advances in reactor engineering design that integrate light-delivery and electrochemical system requirements are presented, with a description of photo-electrode material advances, including doping, nano-decoration, and nanostructure control. Disinfection and cell inactivation are described using different model microorganisms such as E. coli, Mycobacteria, Legionella, etc., as well the fungus Candida parapsilosis, with relevant figures of merit. The key advances in the elucidation of bacterial inactivation mechanisms by photoelectrocatalytic treatments are presented and knowledge gaps identified. Finally, prospects and further research needs are outlined, to define the pathway towards the future of photoelectrocatalytic disinfection technologies.
Visible-Light Radical–Radical Coupling vs. Radical Addition: Disentangling a Mechanistic Knot
Authors: Aguilar-Galindo Fernando , Rodríguez Ricardo I. , Mollari Leonardo , Alemán José , Díaz-Tendero Sergio
Published: July 2021

A highly enantioselective protocol has been recently described as allowing the synthesis of five-membered cyclic imines harnessing the selective generation of a β-Csp3-centered radical of acyl heterocyclic derivatives and its subsequent interaction with diverse NH-ketimines. The overall transformation represents a novel cascade process strategy crafted by individual well-known steps; however, the construction of the new C-C bond highlights a crucial knot from a mechanistically perspective. We believe that the full understanding of this enigmatic step may enrich the current literature and expand latent future ideas. Therefore, a detailed mechanistic study of the protocol has been conducted. Here, we provide theoretical insight into the mechanism using quantum chemistry calculations. Two possible pathways have been investigated: (a) imine reduction followed by radical–radical coupling and (b) radical addition followed by product reduction. In addition, investigations to unveil the origin behind the enantioselectivity of the 1-pyrroline derivatives have been conducted as well.
Familiarity Breeds Strategy: In Silico Untangling of the Molecular Complexity on Course of Autoimmune Liver Disease-to-Hepatocellular Carcinoma Transition Predicts Novel Transcriptional Signatures
Authors: Mukherjee Soumyadeep , Kar Arpita , Khatun Najma , Datta Puja , Biswas Avik , Barik Subhasis
Published: July 2021

Autoimmune liver diseases (AILD) often lead to transformation of the liver tissues into hepatocellular carcinoma (HCC). Considering the drawbacks of surgical procedures in such cases, need of successful non-invasive therapeutic strategies and treatment modalities for AILD-associated-HCC still exists. Due to the lack of clear, sufficient knowledge about factors mediating AILD-to-HCC transition, an in silico approach was adopted to delineate the underlying molecular deterministic factors. Parallel enrichment analyses on two different public microarray datasets (GSE159676 and GSE62232) pinpointed the core transcriptional regulators as key players. Correlation between the expression kinetics of these transcriptional modules in AILD and HCC was found to be positive primarily with the advancement of hepatic fibrosis. Most of the regulatory interactions were operative during early (F0–F1) and intermediate fibrotic stages (F2–F3), while the extent of activity in the regulatory network considerably diminished at late stage of fibrosis/cirrhosis (F4). Additionally, most of the transcriptional targets with higher degrees of connectivity in the regulatory network (namely DCAF11, PKM2, DGAT2 and BCAT1) may be considered as potential candidates for biomarkers or clinical targets compared to their low-connectivity counterparts. In summary, this study uncovers new possibilities in the designing of novel prognostic and therapeutic regimen for autoimmunity-associated malignancy of liver in a disease progression-dependent fashion.
Lower Temperatures Exacerbate NLRP3 Inflammasome Activation by Promoting Monosodium Urate Crystallization, Causing Gout
Authors: Ahn Huijeong , Lee Gilyoung , Lee Geun-Shik
Published: July 2021

Gout is a recurrent and chronic form of arthritis caused by the deposition of monosodium urate (MSU) crystals in the joints. Macrophages intake MSU crystals, the trigger for NLRP3 inflammasome activation, which leads to the release of interleukin (IL)-1β and results in the flaring of gout. The effects of temperature, an environmental factor for MSU crystallization, on IL-1β secretion have not been well studied. This study examined the effects of temperature on inflammasome activation. Specific triggers activated canonical inflammasomes (NLRP3, NLRC4, and AIM2) in murine macrophages at various temperatures (25, 33, 37, 39, and 42 °C). The maturation of IL-1β and caspase-1 was measured as an indicator for inflammasome activation. As expected, the optimal temperature of inflammasome activation was 37 °C. The MSU crystal-mediated activation of inflammasome increased at temperatures lower than 37 °C and decreased at higher temperatures. MSU crystals at lower temperatures enhanced IL-1β secretion via the NLRP3 inflammasome pathway. A lower temperature promoted the formation of MSU crystals without changing phagocytosis. Overall, lower temperatures form more MSU crystals and enhance NLRP3 inflammasome activation. In light of these findings, it is possible that hyperthermia therapy may reduce gout flaring.
Perspectives and Issues in the Assessment of SMARCA4 Deficiency in the Management of Lung Cancer Patients
Authors: Armon Subasri , Hofman Paul , Ilié Marius
Published: July 2021

Lung cancers are ranked third among the cancer incidence in France in the year 2020, with adenocarcinomas being the commonest sub-type out of ~85% of non-small cell lung carcinomas. The constant evolution of molecular genotyping, which is used for the management of lung adenocarcinomas, has led to the current focus on tumor suppressor genes, specifically the loss of function mutation in the SMARCA4 gene. SMARCA4-deficient adenocarcinomas are preponderant in younger aged male smokers with a predominant solid morphology. The importance of identifying SMARCA4-deficient adenocarcinomas has gained interest for lung cancer management due to its aggressive behavior at diagnosis with vascular invasion and metastasis to the pleura seen upon presentation in most cases. These patients have poor clinical outcome with short overall survival rates, regardless of the stage of disease. The detection of SMARCA4 deficiency is possible in most pathology labs with the advent of sensitive and specific immunohistochemical antibodies. The gene mutations can be detected together with other established lung cancer molecular markers based on the current next generation sequencing panels. Sequencing will also allow the identification of associated gene mutations, notably KRAS, KEAP1, and STK11, which have an impact on the overall survival and progression-free survival of the patients. Predictive data on the treatment with anti-PD-L1 are currently uncertain in this high tumor mutational burden cancer, which warrants more groundwork. Identification of target drugs is also still in pre-clinical testing. Thus, it is paramount to identify the SMARCA4-deficient adenocarcinoma, as it carries worse repercussions on patient survival, despite having an exceptionally low prevalence. Herein, we discuss the pathophysiology of SMARCA4, the clinicopathological consequences, and different detection methods, highlighting the perspectives and challenges in the assessment of SMARCA4 deficiency for the management of non-small cell lung cancer patients. This is imperative, as the contemporary shift on identifying biomarkers associated with tumor suppressor genes such as SMARCA4 are trending; hence, awareness of pathologists and clinicians is needed for the SMARCA4-dNSCLC entity with close follow-up on new management strategies to overcome the poor possibilities of survival in such patients.
Fungal Associates of Soft Scale Insects (Coccomorpha: Coccidae)
Authors: Szklarzewicz Teresa , Michalik Katarzyna , Grzywacz Beata , Kalandyk-Kołodziejczyk Małgorzata , Michalik Anna
Published: July 2021

Ophiocordyceps fungi are commonly known as virulent, specialized entomopathogens; however, recent studies indicate that fungi belonging to the Ophiocordycypitaceae family may also reside in symbiotic interaction with their host insect. In this paper, we demonstrate that Ophiocordyceps fungi may be obligatory symbionts of sap-sucking hemipterans. We investigated the symbiotic systems of eight Polish species of scale insects of Coccidae family: Parthenolecanium corni, Parthenolecanium fletcheri, Parthenolecanium pomeranicum, Psilococcus ruber, Sphaerolecanium prunasti, Eriopeltis festucae, Lecanopsis formicarum and Eulecanium tiliae. Our histological, ultrastructural and molecular analyses showed that all these species host fungal symbionts in the fat body cells. Analyses of ITS2 and Beta-tubulin gene sequences, as well as fluorescence in situ hybridization, confirmed that they should all be classified to the genus Ophiocordyceps. The essential role of the fungal symbionts observed in the biology of the soft scale insects examined was confirmed by their transovarial transmission between generations. In this paper, the consecutive stages of fungal symbiont transmission were analyzed under TEM for the first time.
A Nut for Every Bolt: Subunit-Selective Inhibitors of the Immunoproteasome and Their Therapeutic Potential
Authors: Huber Eva M. , Groll Michael
Published: July 2021

At the heart of the ubiquitin–proteasome system, the 20S proteasome core particle (CP) breaks down the majority of intracellular proteins tagged for destruction. Thereby, the CP controls many cellular processes including cell cycle progression and cell signalling. Inhibitors of the CP can suppress these essential biological pathways, resulting in cytotoxicity, an effect that is beneficial for the treatment of certain blood cancer patients. During the last decade, several preclinical studies demonstrated that selective inhibition of the immunoproteasome (iCP), one of several CP variants in mammals, suppresses autoimmune diseases without inducing toxic side effects. These promising findings led to the identification of natural and synthetic iCP inhibitors with distinct chemical structures, varying potency and subunit selectivity. This review presents the most prominent iCP inhibitors with respect to possible scientific and medicinal applications, and discloses recent trends towards pan-immunoproteasome reactive inhibitors that cumulated in phase II clinical trials of the lead compound KZR-616 for chronic inflammations.
Neighborhood Contexts and Oral Health Outcomes in a Pediatric Population: An Exploratory Study
Authors: Podskalniy Vladyslav A. , Pani Sharat Chandra , Lee Jinhyung , Vieira Liliani Aires Candido , Perinpanayagam Hiran
Published: July 2021

Aims: This study aimed to explore the impacts of neighborhood-level socioeconomic contexts on the therapeutic and preventative dental quality outcome of children under 16 years. Materials and Methods: Anonymized billing data of 842 patients reporting to a university children’s dental over three years (March 2017–2020) met the inclusion criteria. Their access to care (OEV-CH-A), topical fluoride application (TFL-CH-A) and dental treatment burden (TRT-CH-A) were determined by dental quality alliance (DQA) criteria. The three oral health variables were aggregated at the neighborhood level and analyzed with Canadian census data. Their partial postal code (FSA) was chosen as a neighborhood spatial unit and maps were created to visualize neighborhood-level differences. Results: The individual-level regression models showed significant negative associations between OEV-CH-A (p = 0.027) and TFL-CH-A (p = 0.001) and the cost of dental care. While there was no significant association between neighborhood-level sociodemographic variables and OEV-CH-A, TRT-CH-A showed a significant negative association at the neighborhood level with median household income and significant positive association with percentage of non-official first language (English or French) speakers. Conclusion: Initial analysis suggests differences exist in dental outcomes according to neighborhood-level sociodemographic variables, even when access to dental care is similar.
Perioperative Glial Fibrillary Acidic Protein Is Associated with Long-Term Neurodevelopment Outcome of Infants with Congenital Heart Disease
Authors: Vergine Michela , Vedovelli Luca , Simonato Manuela , Tonazzo Valentina , Correani Alessio , Cainelli Elisa , Gregori Dario , Padalino Massimo A. , Cogo Paola
Published: July 2021

Background: Brain injury, impaired brain maturation, and long-term neurodevelopmental disorders are common in infants with congenital heart diseases (CHD). We aimed to assess whether plasma glial fibrillary acidic protein (GFAP) can predict neurodevelopmental anomalies in CHD infants operated on cardiopulmonary bypass (CPB). Methods: We measured plasma GFAP in 38 infants at multiple CPB phases. Cognitive, neuropsychological, and psychopathological functioning were assessed 5.7 ± 2.2 years after surgery. We identified an impaired global neurodevelopmental index (NDI) when at least two domains were abnormal. The relationships between NDI, GFAP, and clinical variables were explored with non-supervised feature selection methods and modeled with a nested non-linear logistic regression. Results: Intelligence quotient scores were within the normal range in 84% of children, whereas 58% showed an abnormal NDI, with the greatest impairments in the psychopathological area. The plasma GFAP peak was 0.95 (0.44–1.57) ng/mL, and it was correlated with age, weight, duration of surgery phases, and CPB minimum temperature. In the regression model, the GFAP peak was associated with an impaired NDI with a possible flexible point toward NDI impairment at 0.49 ng/mL, keeping constant ICU stay, CPB duration, CHD anatomy, weight, and CPB minimum temperature. Conclusion: GFAP is a promising early marker of abnormal long-term neuropsychological development.
Artificial Intelligence-Based Optimization of a Bimorph-Segmented Tapered Piezoelectric MEMS Energy Harvester for Multimode Operation
Authors: Pertin Osor , Guha Koushik , Jakšić Olga
Published: July 2021

This paper presents a study on the design and multiobjective optimization of a bimorph-segmented linearly tapered piezoelectric harvester for low-frequency and multimode vibration energy harvesting. The procedure starts with a significant number of FEM simulations of the structure with different geometric dimensions—length, width, and tapering ratio. The datasets train the artificial neural network (ANN) that provides the fitting function to be modified and used in algorithms for optimization, aiming to achieve minimal resonant frequency and maximal generated power. Levenberg–Marquardt (LM) and scaled conjugate gradient (SCG) methods were used to train the ANN, then the goal attainment method (GAM) and genetic algorithm (GA) were used for optimization. The dominant solution resulted from optimization by the genetic algorithm integrated with the ANN fitting function obtained by the SCG training method. The optimal piezoelectric harvester is 121.3 mm long and 71.56 mm wide and has a taper ratio of 0.7682. It ensures over five times greater output power at frequencies below 200 Hz, which benefits the low frequency of the vibration spectrum. The optimized design can harness the power of higher-resonance modes for multimode applications.
Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response
Authors: Grubmüller Bernhard , Jahrreiss Victoria , Brönimann Stephan , Quhal Fahad , Mori Keiichiro , Heidenreich Axel , Briganti Alberto , Tilki Derya , Shariat Shahrokh F.
Published: July 2021

A valid treatment option for recurrence after definite radiotherapy (RT) for localized prostate cancer (PC) is salvage radical prostatectomy (SRP). However, data on SRP are scarce, possibly resulting in an underutilization. A systematic review was performed using MEDLINE (Pubmed), Embase, and Web of Science databases including studies published between January 1980 and April 2020. Overall, 23 English language articles including a total number of 2323 patients were selected according to PRISMA criteria. The overall median follow-up was 37.5 months (IQR 35.5–52.5). Biochemical-recurrence (BCR)-free probability ranged from 34% to 83% at five years, respectively, and from 31% to 37% at 10 years. Cancer specific survival (CSS) and overall survival (OS) ranged from 88.7% to 98% and 64% to 95% at five years and from 72% to 83% and 65% to 72% at 10 years, respectively. Positive surgical margins ranged from 14% to 45.8% and pathologic organ-confined disease was reported from 20% to 57%. The rate of pathologic > T2-disease ranged from 37% to 80% and pN1 disease differed between 0% to 78.4%. Pre-SRP PSA, pre-SRP Gleason Score (GS), pathologic stage after SRP, and pathologic lymph node involvement seemed to be the strongest prognostic factors for good outcomes. SRP provides accurate histopathological and functional outcomes, as well as durable cancer control. Careful patient counseling in a shared decision-making process is recommended.
Molecular Characterization of the Common Snook, Centropomus undecimalis (Bloch, 1792) in the Usumacinta Basin
Authors: Terán-Martínez Jazmín , Rodiles-Hernández Rocío , Garduño-Sánchez Marco A. A. , Ornelas-García Claudia Patricia
Published: July 2021

The common snook is one of the most abundant and economically important species in the Usumacinta basin in the Gulf of Mexico, which has led to overfishing, threatening their populations. The main goal of the present study was to assess the genetic diversity and structure of the common snook along the Usumacinta River in order to understand the population dynamics and conservation status of the species. We characterized two mitochondrial markers (mtCox1 and mtCytb) and 11 microsatellites in the Usumacinta basin, which was divided into three zones: rainforest, floodplain and river delta. The mitochondrial data showed very low diversity, showing some haplotypic diversity differences between the rainforest and delta zones. In contrast, we consistently recovered two genetic clusters in the Usumacinta River basin with the nuclear data in both the DAPC and STRUCTURE analyses. These results were consistent with the AMOVA analyses, which showed significant differences among the genetic clusters previously recovered by DAPC and STRUCTURE. In terms of diversity distribution, the floodplain zone corresponded to the most diverse zone according to the mitochondrial and nuclear data, suggesting that this is a transition zone in the basin. Our results support the relevance of the molecular characterization and monitoring of the fishery resources at the Usumacinta River to better understand their connectivity, which could help in their conservation and management.
Distinct Reproductive Strategy of Two Endemic Amazonian Quillworts
Authors: Caldeira Cecilio F. , Lopes Arthur V. S. , Aguiar Keyvilla C. , Ferreira Aline L. , Araujo João V. S. , Gomes Vinnícius M. S. , Zandonadi Daniel B. , Abranches Cinthia B. , Ramos Silvio J. , Gastauer Markus , Campos Naiara V. , Gestinari Lísia M. S. , Prado Luis A. , Santos Fernando M. G. , Martins Rodrigo L. , Esteves Francisco A. , Oliveira Guilherme , Santos Mirella P.
Published: July 2021

We examined the reproductive strategy of two Amazonian quillworts (Isoëtes cangae and Isoëtes serracarajensis), endemic and threatened species of canga ecosystems. Sexual propagation was examined by in vitro fertilization assays, while asexual propagation was examined by tiller emission. Isoëtes cangae is an outcrossing species that reproduces exclusively by spore germination and is able to propagate by self- and cross-fertilization. Isoëtes serracarajensis reproduces asexually by emitting tillers from the plant corm, despite producing male and female sporangia. These distinct reproductive strategies in the different species may be linked to their contrasting habitats. Isoëtes cangae inhabit a permanent oligotrophic lake with mild environmental changes, while I. serracarajensis are found in temporary ponds facing severe seasonal drought, where asexual propagation may represent an adaptive advantage to the short growth period during access to water. We also observed different relationships between plant growth and reproductive traits between the species, despite their common production of sporophytes with high survival rates. Together, these results are of paramount importance for establishing conservation plans for both species considering the advantages of sexual propagation to maintain the genetic diversity of I. cangae and the diligent management required to do the same with asexually propagated I. serracarajensis.
Quantifying Southern Pacific Rattlesnake (Crotalus oreganus helleri) Hunting Behavior through Community Science
Authors: Urquidi Emily R. , Putman Breanna J.
Published: July 2021

It is increasingly important to study animal behaviors as these are the first responses organisms mount against environmental changes. Rattlesnakes, in particular, are threatened by habitat loss and human activity, and require costly tracking by researchers to quantify the behaviors of wild individuals. Here, we show how photo-vouchered observations submitted by community members can be used to study cryptic predators like rattlesnakes. We utilized two platforms, iNaturalist and HerpMapper, to study the hunting behaviors of wild Southern Pacific Rattlesnakes. From 220 observation photos, we quantified the direction of the hunting coil (i.e., “handedness”), microhabitat use, timing of observations, and age of the snake. With these data, we looked at whether snakes exhibited an ontogenetic shift in behaviors. We found no age differences in coil direction. However, there was a difference in the microhabitats used by juveniles and adults while hunting. We also found that juveniles were most commonly observed during the spring, while adults were more consistently observed throughout the year. Overall, our study shows the potential of using community science to study the behaviors of cryptic predators.
Placental Types and Effective Perinatal Management of Vasa Previa: Lessons from 55 Cases in a Single Institution
Authors: Tachibana Daisuke , Misugi Takuya , Pooh Ritsuko K. , Kitada Kohei , Kurihara Yasushi , Tahara Mie , Hamuro Akihiro , Nakano Akemi , Koyama Masayasu
Published: July 2021

Background: We aimed to identify clinical characteristics and outcomes for each placental type of vasa previa (VP). Methods: Placental types of vasa previa were defined as follows: Type 1, vasa previa with velamentous cord insertion and non-type 1, vasa previa with a multilobed or succenturiate placenta and vasa previa with vessels branching out from the placental surface and returning to the placental cotyledons. Results: A total of 55 cases of vasa previa were included in this study, with 35 cases of type 1 and 20 cases of non-type 1. Vasa previa with type 1 showed a significantly higher association with assisted reproductive technology, compared with non-type 1 (p = 0.024, 60.0% and 25.0%, respectively). The diagnosis was significantly earlier in the type 1 group than in the non-Type 1 group (p = 0.027, 21.4 weeks and 28.6 weeks, respectively). Moreover, the Ward technique for anterior placentation to avoid injury of the placenta and/or fetal vessels was more frequently required in non-type 1 cases (p < 0.001, 60.0%, compared with 14.3% for type 1). Conclusion: The concept of defining placental types of vasa previa will provide useful information for the screening of this serious complication, improve its clinical management and operative strategy, and achieve more preferable perinatal outcomes.
A Qualitative Assessment of the Pedagogical Process at Czech Public Universities
Authors: Bečica Jiří , Vavrek Roman
Published: July 2021

Quality is currently an often-used term in all areas of human activity. However, the measurement of quality is very problematic in the field of education, particularly if no specific, comprehensible criteria for its measurement, accepted by most subjects active in the specific sector, exist. Monitoring quality in the field of education is difficult because there is no long-term embedded quality standard and the established level can be affected not only by the selection of the chosen criteria for measurement, but also by determining specific weights when comparing the importance of the chosen criteria. The authors of this paper endeavour to point out one way of assessing the quality of publicly established universities in the Czech Republic during the academic years 2011/2012 and 2018/2019 on a basic sample of all 26 publicly established universities. The quality of the pedagogic apparatus and the converted number of students indicate that the classification of schools into categories according to the Ministry of Education, Youth, and Sports of the Czech Republic (MEYS) is possible, but the individual categories should be discussed and modified according to the assessment performed.
Automatic Categorization of LGBT User Profiles on Twitter with Machine Learning
Authors: Karami Amir , Lundy Morgan , Webb Frank , Boyajieff Hannah R. , Zhu Michael , Lee Dorathea
Published: July 2021

Privacy needs and stigma pose significant barriers to lesbian, gay, bisexual, and transgender (LGBT) people sharing information related to their identities in traditional settings and research methods such as surveys and interviews. Fortunately, social media facilitates people’s belonging to and exchanging information within online LGBT communities. Compared to heterosexual respondents, LGBT users are also more likely to have accounts on social media websites and access social media daily. However, the current relevant LGBT studies on social media are not efficient or assume that any accounts that utilize LGBT-related words in their profile belong to individuals who identify as LGBT. Our human coding of over 16,000 accounts instead proposes the following three categories of LGBT Twitter users: individual, sexual worker/porn, and organization. This research develops a machine learning classifier based on the profile and bio features of these Twitter accounts. To have an efficient and effective process, we use a feature selection method to reduce the number of features and improve the classifier’s performance. Our approach achieves a promising result with around 88% accuracy. We also develop statistical analyses to compare the three categories based on the average weight of top features.
Towards Sustainable Development Goal 7 “Universal Access to Clean Modern Energy”: National Strategy in Rwanda to Scale Clean Cooking with Bottled Gas
Authors: Čukić Iva , Kypridemos Chris , Evans Alex W. , Pope Daniel , Puzzolo Elisa
Published: July 2021

More than 90% of Rwandans rely on polluting solid fuels to meet their cooking needs. The negative impacts on health, climate, and the environment have led the Rwandan government to set a target of halving that number to 42% by 2024. A National Master Plan to promote scale up of liquefied petroleum gas (LPG) has been developed to define (i) the necessary market conditions, (ii) public and private sector interventions, and (iii) the expected societal impacts. Findings are reported from modelling scenarios of scaling LPG use towards the 2024 policy target and the 2030 target for “universal access to clean modern energy” (SDG7). Household LPG use is projected to increase from 5.6% in 2020 to 13.2% by 2024 and 38.5% by 2030. This level of adoption could result in a reduction of 7656 premature deaths and 403,664 disability-adjusted-life-years (DALYs), as well as 243 million trees saved. Reductions in carbon dioxide and black carbon emissions equivalents (CO2e and BCe, respectively) are estimated to reach 25.6 million MT and 14.9 MT, respectively, by 2030. While aggressive policy intervention is required, the health, environmental, and developmental benefits are clear. Implementation of the Rwanda National LPG Master Plan will provide a model for other sub-Saharan African countries to address the priorities for cessation of reliance on solid fuels as an energy source.
A Review of Urban Green and Blue Infrastructure from the Perspective of Food-Energy-Water Nexus
Authors: Shah Aamir Mehmood , Liu Gengyuan , Meng Fanxin , Yang Qing , Xue Jingyan , Dumontet Stefano , Passaro Renato , Casazza Marco
Published: July 2021

Small scale urban green-blue infrastructure (indicated as GBI hereafter) comprises huge underexploited areas for urban development and planning. This review article aims to highlight the relevance and knowledge gaps regarding GBI from the perspective of the food–energy–water (FEW) nexus, these being key resources for the survival of human communities. In particular, this review was focused on publications on urban ecosystem services (positive effects) and dis-services (negative effects) associated with different GBI typologies. The review proved that GBI can contribute environmentally, socially, and economically to FEW security and urban sustainability. Yet, such positive effects must be considered against ecosystem dis-services tradeoffs, including urban food production, commonly connected with heavy water and energy consumption, specifically under dry climate conditions, and sometimes related to an excessive use of manure, pesticides, or fertilizers. These conditions could pose either a risk to water quality and local insect survival or serve enhanced mosquito breeding because of irrigation. Up to now, the review evidenced that few nexus modeling techniques have been discussed in terms of their benefits, drawbacks, and applications. Guidance is provided on the choice of an adequate modeling approach. Water, energy, and food are intrinsically associated physically. However, depending on their management, their tradeoffs are often increased. There is a need to minimize these tradeoffs and to build up synergies between food, energy, and water using a holistic approach. This is why the FEW nexus approach offers good insights to address the relation between three important individual resource components of sustainability.
High-Speed Infrared Measurement of Injector Tip Temperature during Diesel Engine Operation
Authors: Gander Alex , Sykes Dan , Payri Raúl , de Sercey Guillaume , Kennaird Dave , Gold Martin , Pearson Richard J. , Crua Cyril
Published: July 2021

Pre-catalyst engine emissions and detrimental injector deposits have been widely associated with the near-nozzle fluid dynamics during and after the injection events. Although the heating and evaporation of fuel films on the nozzle surface directly affects some of these processes, there are no experimental data for the transient evolution of nozzle surface temperature during typical engine conditions. In order to address this gap in knowledge, we present a non-intrusive approach for the full-cycle time resolved measurement of the surface temperature of production nozzles in an optical engine. A mid-wave infrared high-speed camera was calibrated against controlled conditions, both out of engine and in-engine to account for non-ideal in surface emissivity and optical transmissivity. A custom-modified injector with a thermocouple embedded below the nozzle surface was used to validate the approach under running engine conditions. Calibrated infrared thermography was then applied to characterise the nozzle temperature at 1200 frames per second, during motored and fired engine operation, thus revealing for the first time the effect of transient operating conditions on the temperature of the injector nozzle’s surface.
Environmental Production Efficiency in the European Union Countries as a Tool for the Implementation of Goal 7 of the 2030 Agenda
Authors: Cheba Katarzyna , Bąk Iwona
Published: July 2021

The main purpose of the paper is to present a proposal to measure the relationships between Goal 7 of the 2030 Agenda for Sustainable Development and one of the areas considered in the green growth concept: environmental production efficiency. Both of these areas illustrate the relationship between the natural environment and the economy, emphasizing transformations in the field of energy use. Selected taxonomic methods, TOPSIS, and multicriteria taxonomy, were applied to study the relationships between the two areas. The results of the EU countries classification showed a variety of countries’ development pathways within a single economic community. Despite continued attempts to equalize the development levels between European Union countries in many strategic areas, they remain highly diversified. That is also true for the areas analyzed in the paper, which is a disturbing situation, indicating that both strategies might not correlate in all respects. Further research into the relationships linking the remaining dimensions of both strategies is required.
An Integrated Single-Valued Neutrosophic Combined Compromise Solution Methodology for Renewable Energy Resource Selection Problem
Authors: Rani Pratibha , Ali Jabir , Krishankumar Raghunathan , Mishra Arunodaya Raj , Cavallaro Fausto , Ravichandran Kattur S.
Published: July 2021

Optimal renewable energy source (RES) selection needs a strategic decision for reducing environmental pollutions, use of conventional resources, and improving economic development. In the process of RESs evaluation, several aspects like environmental, economic, social, and technical requirements play an important role. In addition, diverse factors affect the appropriate RES selection problem which adheres to uncertain and imprecise data. Thus, this selection process can be considered as a complex uncertain multi-criteria decision making (MCDM) problem. This study aims to introduce a novel integrated methodology based on Step-wise Weight Assessment Ratio Analysis (SWARA) and Combined Compromise Solution (CoCoSo) methods within single-valued neutrosophic sets (SVNSs) context, wherein the decision-makers and criteria weights are completely unknown. In the proposed approach, the criteria weights are determined by the SWARA method, and the most suitable RES alternative is determined by an improved CoCoSo method under the SVN context. Further, an illustrative case study of RES selection is considered to demonstrate the thorough execution process of the proposed method. Moreover, a comparison with existing methods is discussed to analyze the validity of the obtained result. This study performs sensitivity analysis with a various set of criteria weights to reveal the robustness of the developed approach. The strength of the proposed method is its practical applicability and ability to provide solutions under uncertain, imperfect, indeterminate, and inconsistent information.