bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeted Treatment of Soft-Tissue Sarcoma
Authors: Riskjell Anne Iren , Mäkinen Vivi-Nelli , Sandfeld-Paulsen Birgitte , Aggerholm-Pedersen Ninna
Published: April 2023

Background: Soft-tissue sarcoma (STS) is a heterogeneous group of sarcomas with a low incidence. The treatment of advanced disease is poor, and mortality is high. We aimed to generate an overview of the clinical experiences with targeted treatments based on a pre-specified target in patients with STS. Methods: A systematic literature search was conducted in PubMed and Embase databases. The programs ENDNOTE and COVIDENCE were used for data management. The literature was screened to assess the article’s eligibility for inclusion. Results: Twenty-eight targeted agents were used to treat 80 patients with advanced STS and a known pre-specified genetic alteration. MDM2 inhibitors were the most-studied drug (n = 19), followed by crizotinib (n = 9), ceritinib (n = 8), and 90Y-OTSA (n = 8). All patients treated with the MDM2 inhibitor achieved a treatment response of stable disease (SD) or better with a treatment duration of 4 to 83 months. For the remaining drugs, a more mixed response was observed. The evidence is low because most studies were case reports or cohort studies, where only a few STS patients were included. Conclusions: Many targeted agents can precisely target specific genetic alterations in advanced STS. The MDM2 inhibitor has shown promising results.
Visits to Sexually Transmitted Infection Clinics in Italy from January 2016 to November 2021: A Multicenter, Retrospective Study
Authors: Borghi Alessandro , Flacco Maria Elena , Pacetti Lucrezia , Orioni Gionathan , Marzola Elisa , Cultrera Rosario , Guerra Valentina , Manfredini Roberto , Gaspari Valeria , Segala Daniela , Corazza Monica
Published: April 2023

There is no evidence of seasonal variation in visits to clinics dedicated to sexually transmitted infections (STIs) in Italy, nor of changes after the advent of the COVID-19 pandemic. An observational, retrospective, multicentric study was conducted to record and analyze all the visits to the STI clinics of the Dermatology Units of the University Hospitals of Ferrara and Bologna and of the Infectious Disease Unit of Ferrara, Italy, between January 2016 and November 2021. Overall, 11.733 visits were registered over a 70-month study period (63.7% males, mean age 34.5 ± 12.8 yrs). The mean number of monthly visits significantly decreased from the advent of the pandemic (136) compared to before (177). In the pre-pandemic period, visits to STI clinics increased in the autumn/winter months when compared to spring/summer, while the trend was the opposite in the pandemic period. Thus, during the pandemic, both an overall significant reduction in visits to STI clinics and a reversal in their seasonality were observed. These trends affected males and females equally. The marked decrease, mostly found in the pandemic winter months, can be linked to the “lockdown”/self-isolation ordinances and social distancing measures during the colder months, coinciding with the spread of the COVID-19 infection, which limited the opportunities for meeting and socializing.
Screening Differential Expression Profiles of Urinary microRNAs in a Gentamycin-Induced Acute Kidney Injury Canine Model
Authors: Sun Bo , Chen Liang , Qu Zhe , Yang Yan-Wei , Miao Yu-Fa , Wang Rui-Li , Zhou Xiao-Bing , Li Bo
Published: April 2023

microRNAs (miRNAs) are promising biomarkers for different pathological models because of their stable and detectable characters in biofluids. Here, we collected urine samples from 5 beagle dogs on the 3th, 6th, and 12th day in an acute kidney injury (AKI) caused by gentamycin. miRNA levels were measured with high-throughput sequencing and the results were then differentially investigated. Gene Ontology (GO) and KEGG pathway analysis were performed to analyze potential target genes corresponding to the differentially expressed miRNAs (DE-miRNAs). Relationships between hub genes and DE-miRNAs were analyzed with STRING and Cytoscape. We identified 234 DE-miRNAs 3, 6, and 12 days after gentamycin treatment (p < 0.05). Top 10 up- and down-regulated candidate target genes of DE-miRNAs were predicted by overlapping TargetScan and miRanda results). GO and KEGG analyses for DE-miRNAs demonstrated that the DE-miRNAs target genes are mainly involved in kidney injury-related pathways, such as the insulin signaling pathway, oxytocin signaling pathway, and hedgehog signaling pathway. The network of miRNA-hub genes suggests that miR-452, miR-106a, and 106b participate in regulating the largest number of hub genes. We evaluated the miRNA signature via a canine model built by gentamycin-caused acute kidney injury. Our results represent a valuable resource for evaluating miRNAs as biomarkers of renal toxicity.
Spatial Distribution of the Fertility Parameters in Sericulture Soil: A Case Study of Dimapur District, Nagaland
Authors: Jigyasu Dharmendra Kumar , Kumar Amit , Shabnam Aftab Ahmad , Sharma Gulshan Kumar , Jena Roomesh Kumar , Das Bachaspati , Naik Vinodakumar Somashing , Ahmed Siddique Ali , Kumari Kasthala Mary Vijaya
Published: April 2023

Dimapur (Nagaland, India) is dominated by undifferentiated hillside slopes and alluvial plains. The Muga and Eri silk industries are important cultural and economic activities for the inhabitants of Dimapur. Profitable silk production requires adequate quality and quantity of healthy leaves and is highly dependent on the soil fertility of the region. Keeping this in view, the present study was carried out as a first attempt to prepare a geographic information system (GIS) map for Muga and Eri soils in Dimapur, Nagaland. A total 65 surface (0–15 cm) soil samples from Muga farms and 79 surface soil samples from Eri farms were collected and analysed for soil pH, organic carbon content and availability of macro- and micronutrients. Soils of both Muga and Eri farms were found to be extremely (<3.05) to moderately (5.09–6.84) acidic. Soils of Muga and Eri farms were found to have low to high organic carbon content (from 0.24 to 1.98%), low to high available nitrogen content (179.8–612.5 kg ha−1) and medium available phosphorus content (2.68–154.6 kg ha−1). The sulphur availability index was 0.26 and 11.81 for Muga and Eri host plant farms, respectively. The multi-macronutrient map revealed that 46.95% of the district’s total geographical area (TGA) showed deficiencies in one or more macronutrients (high priority zone). Thus, these regions need urgent attention in terms of nutrient management decisions in order to reduce the declining trend of soil fertility and achieve sustainable sericulture production.
Nematocidal and Bactericidal Activities of Green Synthesized Silver Nanoparticles Mediated by Ficus sycomorus Leaf Extract
Authors: Elkobrosy Dina , Al-Askar Abdulaziz A. , El-Gendi Hamada , Su Yiming , Nabil Rokaia , Abdelkhalek Ahmed , Behiry Said
Published: April 2023

Nanoparticles effectively control most plant pathogens, although research has focused more on their antimicrobial than their nematocidal properties. This study synthesized silver nanoparticles (Ag-NPs) through a green biosynthesis method using an aqueous extract of Ficus sycomorus leaves (FS-Ag-NPs). The nanoparticles were characterized using SEM, TEM, EDX, zeta sizer, and FTIR. The TEM results showed that the synthesized NPs were nanoscale and had an average particle size of 33 ± 1 nm. The elemental silver signal at 3 keV confirmed the formation of Ag-NPs from an aqueous leaf extract of F. sycomorus. The FTIR analysis revealed the existence of several functional groups in the prepared Ag-NPs. The strong-broad band detected at 3430 cm−1 indicated the stretching vibration of -OH (hydroxyl) and -NH2 (amine) groups. The nematocidal activity of biosynthesized FS-Ag-NPs has been evaluated in vitro against the root-knot nematode Meloidogyne incognita at 24, 48, and 72 h. The FS-Ag-NPs at a 200 µg/mL concentration applied for 48 h showed the highest effectiveness, with 57.62% nematode mortality. Moreover, the biosynthesized FS-Ag-NPs were also tested for their antibacterial activity against Pectobacterium carotovorum, P. atrosepticum, and Ralstonia solanacearum. With the application of nanoparticles, the reduction in bacterial growth gradually increased. The most potent activity at all concentrations was found in R. solanacearum, with values of 14.00 ± 2.16, 17.33 ± 2.05, 19.00 ± 1.41, 24.00 ± 1.41, and 26.00 ± 2.83 at concentrations of 5, 10, 15, 20, and 25 µg/mL, respectively, when compared with the positive control (Amoxicillin 25 µg) with a value of 16.33 ± 0.94. At the same time, the nanoparticles showed the lowest reduction values against P. atrosepticum when compared to the control. This study is the first report on the nematocidal activity of Ag-NPs using F. sycomorus aqueous extract, which could be a recommended treatment for managing plant-parasitic nematodes due to its simplicity, stability, cost-effectiveness, and environmentally safe nature.
Tilting-Pad Bearings—The Contact Flexibility of the Pivot
Authors: Wagner Laurence F.
Published: April 2023

The modeling of tilting-pad journal and thrust bearings presents a level of complexity beyond that of bearings with a fixed-arc geometry, particularly with regard to their dynamic influences. With tilting-pad bearings, the theory surrounding their fluid film must be complemented with the representative modeling of the pad dynamics. What has been recognized in recent decades is the significance of the pad support, in particular the flexibility of the pivot region of the pad. The typical model for including the stiffness of the pivot is based on the Hertzian contact theory. Some researchers have noted that the Hertzian theory does not permit sufficient flexibility in the pivot region. It has been suggested that the contact mechanics at the pivot would be better represented as a pairing of rough surfaces. The modeling used here is based on a statistical asperity micro-contact theory for rough surface line contact that has been extended to include contact stiffness. This model has been applied to the determination of the effective dynamic properties of tilting-pad bearings. The results show that pivot stiffness can be as low as one third of the stiffness determined by the Hertzian theory. A comparison to published experimental results confirms the significance of the rough surface modeling, particularly for the line contacts associated with rocker-back tilting pads.
Thermo-Hydrodynamic Lubrication Analysis of Slipper Pair Considering Wear Profile
Authors: Mo Hu , Hu Yanping , Quan Song
Published: April 2023

The profile of sealing land is a sensitive factor affecting the thermo-hydrodynamic lubrication characteristics of the slipper pair. In this paper, the non-uniform wear of the running surface under the slipper was presented and defined as the boundary condition. Based on the finite volume method and the successive over-relaxation iteration method, a discrete numerical model coupled with the temperature, pressure, and thickness of the oil film was constructed. The Newton and sequential circulation methods were used to solve the coupling equations. The influence of the wear profile on the film thickness, sliding attitude, and leakage were discussed. The analyzed results show that the control of the wear on the outer side of sealing land and the contour vertex position, and the avoidance of the wear on the inner side of sealing land could improve the thermo-hydrodynamic lubrication performance of the slipper pair.
9-Methoxynaphtho[1,2-b]benzofuran
Authors: Miani Roberto , Vigna Jacopo , Mancini Ines
Published: April 2023

A highly selective one-pot microwave-assisted synthesis of 9-methoxynaphtho[1,2-b]benzofuran was obtained by treating 1-naphthol with 1-bromo-4-methoxy-2-nitrobenzene and two molar equivalents of potassium tert-butoxide in dimethyl sulfoxide. The selectivity in the production of the title compound was addressed by the suitable position of the bromine and nitro group on the aryl reagent. Moreover, we highlight how the nitro group plays a dual role, as activator in the first nucleophilic substitution with the release of bromide ion and then as the leaving group in the furan cyclization. Eventually, the product was structurally characterized by MS and extensive NMR analyses.
Evolution of the Growth Mode and Its Consequences during Bulk Crystallization of GaN
Authors: Sochacki Tomasz , Kucharski Robert , Grabianska Karolina , Weyher Jan L. , Zajac Magdalena A. , Iwinska Malgorzata , Kirste Lutz , Bockowski Michal
Published: April 2023

A detailed analysis of morphology of gallium nitride crystal growth obtained by ammonothermal and halide vapor phase epitaxy methods was carried out. The work was conducted to determine the source of triangular planar defects visible in X-ray topography as areas with locally different lattice parameters. It is shown that the occurrence of these defects is related to growth hillocks. Particular attention was paid to analyzing the manner and consequences of merging hillocks. In the course of the study, the nature of the mentioned defects and the cause of their formation were determined. It was established that the appearance of the defects depends on the angle formed between the steps located on the sides of two adjacent hillocks. A universal growth model is presented to explain the cause of heterogeneity during the merging of growth hillocks.
Analysis of Selected Organophosphorus Compounds and Nano-Additives on Thermal, Smoke Properties and Quantities of CO and CO2 of Epoxy Materials
Authors: Staszko Sebastian , Półka Marzena
Published: April 2023

Majority of anthropogenic air pollutants enter the atmosphere as a result of material combustion, industrial production and transport. Fires not only cause air pollution, but also disrupt ecosystems. Knowledge of the flammability parameters and proper flame-retardant modification of materials hinders the origin and spread of a fire, while also protecting against air pollution. The aim of this study was to obtain fire-retardant modifications of the epoxy resin, and then to analyse the effect of the introduced additives on the rate of heat release, the thermokinetic properties and the toxicity of volatile combustible products. The modifiers of the epoxy resin were organophosphorus compounds and aluminium and magnesium hydroxides, with a grain size of 10 nm. The introduced additives were found to be effective flame retardants as they reduced the rate of heat release and the amounts of toxic products of thermal decomposition and combustion. The HRRmax and HRRav values of all fire-retardant modifications were lower compared to the corresponding HRR values of the unmodified epoxy material.
Special Issue: Advancement of Functionalized Mineral Materials and Rock
Authors: Du Xi , Chen Youliang , Fernández-Steeger Tomás Manuel
Published: April 2023

Mineral materials have historically been extensively utilised in human society, and they hold significant prominence in various domains such as military, aerospace, electronics, and environmental conservation [...]
Influence of PEO Electrolyzer Geometry on Current Density Distribution and Resultant Coating Properties on Zr-1Nb Alloy
Authors: Aubakirova Veta , Gunderov Dmitry , Farrakhov Ruzil , Astanin Vasily , Stotskiy Andrey , Sharipov Arseny , Demin Alexey , Khalilov Leonard , Parfenov Evgeny
Published: April 2023

This paper is devoted to the study of the current density distribution effect on plasma electrolytic oxidation process and resultant coatings on a Zr-1Nb alloy. The influence of the distance between the plates simultaneously placed into an electrolyzer was evaluated to assess the throwing power of the PEO process. The current density on the facing surfaces of the plates decreases when the distance between them shrinks. This current density has a notable impact on the resultant PEO coating in terms of the surface morphology parameters and electrochemically evaluated corrosion resistance. The influence of this effect is low on the stages of anodizing and spark discharges (60–120 s of the PEO), and significantly increases on the stage of microarc discharges (120–360 s of the PEO). The coating obtained with a smaller distance between the plates, while having the same coating thickness as the others, exhibits higher wear resistance. New correlations between the current density, diffusion coefficient, time constant of nucleation and the coating thickness in the middle of the facing samples were established; in addition, a correlation of the coating morphology in this area with the roughness parameters RPc, RSm was shown. This study contributes to the development of optimized PEO processes for the simultaneously coated several devices of complex shape, e.g., orthopedic implants.
Hierarchical Carbon Network Composites Derived from ZIF-8 for High-Efficiency Microwave Absorption
Authors: Luo Zhongyi , Wang Zhaohao , Liu Jinshuai , Jin Huihui , Han Chunhua , Wang Xuanpeng
Published: April 2023

Metal–organic framework (MOF)-derived composites have gained wide attention due to their specific structures and enhanced performance. In this work, we prepared carbon nanotubes with Fe nanoparticles connected to two-dimensional (2D) hierarchical carbon network composites via a low-pressure gas–solid reaction strategy. Specifically, the three-dimensional (3D) networks derived from ZIF-8 exploited the carbon nanotubes with the function of charge modulation. Meanwhile, we utilized the interconnected 2D nanostructures to optimize impedance matching and facilitate multiple scattering, ultimately improving the overall microwave absorption performance. Furthermore, based on the well-designed structures, the composites prepared at 800 °C (Fe-N-C@CNTs-800) achieved the best reflection loss (RL) of −58.5 dB, thereby obtaining superior microwave absorption performance. Overall, this study provides a good groundwork for further investigation into the modification and dimension design of novel hierarchical microwave absorbers.
Experimental Study on the Effect of Limestone Powder Content on the Dynamic and Static Mechanical Properties of Seawater Coral Aggregate Concrete (SCAC)
Authors: Qi Juan , Jiang Lili , Zhu Ming , Mu Chaomin , Li Rui
Published: April 2023

The development of island construction concrete can serve as a basis for the development and utilization of island resources. Complying with the principle of using local materials to configure seawater coral aggregate concrete (SCAC) that is able to meet the requirements of island and reef engineering construction could effectively shorten the construction period and cost of island and reef engineering construction. In this paper, quasi-static mechanical experiments and dynamic mechanical experiments were carried out on SCAC with different limestone powder contents. High-speed photography technology and Digital Image Correlation (DIC) were used to monitor the dynamic failure process and strain field of SCAC, and the influence of limestone powder content on the dynamic and static mechanical properties of SCAC was investigated. The results showed that, when the limestone powder content was 20% and 16%, the quasi-static compressive strength and quasi-static tensile strength exhibited the best improvement. Additionally, with increasing limestone powder content, the dynamic tensile strength of SCAC first showed and increasing trend and then a decreasing trend, reaching its maximum value when the limestone powder content was 16%. Moreover, the maximum strain value of SCAC with the same limestone powder content increased with increasing strain rate grade, showing an obvious effect on strain rate.
In Vitro Release and In Vivo Pharmacokinetics of Praziquantel Loaded in Different Polymer Particles
Authors: Pereira Emiliane Daher , da Silva Dutra Luciana , Paiva Thamiris Franckini , de Almeida Carvalho Larissa Leite , Rocha Helvécio Vinícius Antunes , Pinto José Carlos
Published: April 2023

Approximately 1 billion people are affected by neglected diseases around the world. Among these diseases, schistosomiasis constitutes one of the most important public health problems, being caused by Schistosoma mansoni and treated through the oral administration of praziquantel (PZQ). Despite being a common disease in children, the medication is delivered in the form of large, bitter-tasting tablets, which makes it difficult for patients to comply with the treatment. In order to mask the taste of the drug, allow more appropriate doses for children, and enhance the absorption by the body, different polymer matrices based on poly(methyl methacrylate) (PMMA) were developed and used to encapsulate PZQ. Polymer matrices included PMMA nano- and microparticles, PMMA-co-DEAEMA (2-(diethylamino)ethyl methacrylate), and PMMA-co-DMAEMA (2-(dimethylamino)ethyl methacrylate) microparticles. The performances of the drug-loaded particles were characterized in vitro through dissolution tests and in vivo through pharmacokinetic analyses in rats for the first time. The in vitro dissolution studies were carried out in accordance with the Brazilian Pharmacopeia and revealed a good PZQ release profile in an acidic medium for the PMMA-DEAEMA copolymer, reaching values close to 100 % in less than 3 h. The in vivo pharmacokinetic analyses were conducted using free PZQ as the control group that was compared with the investigated matrices. The drug was administered orally at doses of 60 mg/kg, and the PMMA-co-DEAEMA copolymer microparticles were found to be the most efficient release system among the investigated ones, reaching a Cmax value of 1007 ± 83 ng/mL, even higher than that observed for free PZQ, which displayed a Cmax value of 432 ± 98 ng/mL.
Feed Curves for Controlling Ring Rolling Stability in Large-Scale Flat Ring Rolling Process
Authors: Xie Dan , Ouyang Qiu-yue , He Luo-yu , Xu Wu-jiao
Published: April 2023

Due to the large wall thickness difference and serious instability in the large-scale ring rolling process, most studies on the feed curve are not suitable for a large-scale ring. The production cost of the large-scale ring is high, and if plastic instability occurs, it will cause a great waste of resources. Therefore, in this study, a staged feed strategy based on the evolution of ring instability is proposed with the objective of controlling the rolling stability of a large-scale ring. Firstly, based on the law of rolling instability evolution, the rolling stage during the rolling process is divided. Secondly, the coordination of all rolling stages is proposed as a factor to design the feed curve. The feed scheme is determined using the central composite design (CCD) method, and then the established mathematical model is applied to obtain the radial feed curves of a large-scale flat ring with a 5 m diameter for different schemes. Next, the designed feed curve was submitted to finite element method (FEM) simulation. According to the FE simulation results, a rolling map for controlling roundness error, eccentricity and vibration is established. Finally, the feed curve in the stable region is input to the FE simulation and the production trial to obtain the results of roundness error, eccentricity and vibration. A comparison of the simulation and production trial results shows that they are in good agreement, which proves the reliability of the feed curve designed based on the stable rolling region in the roll map. Moreover, the machining amount for both the simulation and production trial is below the maximum machined value.
Eco-Friendly Semi-Interpenetrating Polymer Network Hydrogels of Sodium Carboxymethyl Cellulose/Gelatin for Methylene Blue Removal
Authors: Chen Rongbin , Yang Shanbin , Liu Bing , Liao Youlin
Published: April 2023

The present work describes the potential application of environmentally friendly sodium carboxymethylcellulose/gelatin (CMC/Gel) semi-interpenetrating hydrogels prepared by citric acid as a nontoxic cross-linking agent to adsorb dyes. The prepared hydrogels were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA/DTG), and swelling study. The adsorption performance of CMC/Gel2 (C/G2) hydrogel on methylene blue (MB) was investigated. The results showed the better adsorption conditions: adsorption time of 300 min, initial MB concentration of 500 mg/L, adsorbent dosage of 1.2 g/L, solution pH of 7, and temperature of 30 °C. The adsorption kinetics fit the pseudo-second order kinetics model, and the adsorption isotherm fit the Langmuir isotherm model. The maximum adsorption capacity reached 943.40 mg/g. The adsorption process is a spontaneous exothermic process. After three adsorption–desorption cycles, the removal rate of MB by hydrogel still reached 85%, with good reusability. Consequently, the hydrogel can be used as an environmentally friendly, stable, and efficient adsorbent for dyes in wastewater treatment.
Mechanical Properties and Fracture Microstructure of Polycarbonate under High Strain Rate Tension
Authors: Zhang Sai , Wang Bingqian , Meng Xianming , Chen Yajun
Published: April 2023

In this paper, static and dynamic tensile tests were conducted on two kinds of polycarbonate (HL6157 and A1225BK), combined with the digital image correlation (DIC), for guiding the development of the battery pack of new energy vehicles. The mechanical properties of polycarbonate at low-speed (0.01/s) and high-speed (1/s, 100/s) tension were investigated and the microstructure of the fracture for polycarbonate at different speed tensions was also investigated. The fracture microstructure of two kinds of materials was also investigated in this paper. The tension results showed that as the strain rate increased, the yield strength and modulus increased, and the yield strength of the two materials increased by 30% under high-speed tension. In addition, the fracture strain increase was greater than 10% as the strain rate increased. Meanwhile, for polycarbonate, the strain rate increased, and the fracture toughness increased.
Highly Efficient Oxygen Electrode Obtained by Sequential Deposition of Transition Metal-Platinum Alloys on Graphene Nanoplatelets
Authors: Mladenović Dušan , Daş Elif , Santos Diogo M. F. , Bayrakçeken Yurtcan Ayşe , Šljukić Biljana
Published: April 2023

A set of platinum (Pt) and earth-abundant transition metals (M = Ni, Fe, Cu) on graphene nanoplatelets (sqPtM/GNPs) was synthesised via sequential deposition to establish parallels between the synthesis method and the materials’ electrochemical properties. sqPtM/GNPs were assessed as bifunctional electrocatalysts for oxygen evolution (OER) and reduction (ORR) reactions for application in unitised regenerative fuel cells and metal-air batteries. sqPtFe/GNPs showed the highest catalytic performance with a low potential difference of ORR half-wave potential and overpotential at 10 mA cm−2 during OER, a crucial parameter for bifunctional electrocatalysts benchmarking. A novel two-stage synthesis strategy led to higher electrocatalytic performance by facilitating the reactants’ access to the active sites and reducing the charge-transfer resistance.
Shielding Effectiveness Measurement Method for Planar Nanomaterial Samples Based on CNT Materials up to 18 GHz
Authors: Amaro Andrea , Suarez Adrian , Torres Jose , Martinez Pedro A. , Herraiz Roberto , Alcarria Antonio , Benedito Adolfo , Ruiz Rocio , Galvez Pedro , Penades Antonio
Published: April 2023

The study and measurement of the shielding effectiveness (SE) of planar materials is required to predict the suitability of a certain material to form an enclosed electromagnetic shield. One of the most widely used standards for measuring the SE of planar materials is ASMT D4935-18. It is based on a coaxial sample holder (CSH) that operates up to 1.5 GHz. Due to this standard’s frequency limitations, new variants with higher frequency limits have been developed by decreasing the size of the CSH conductors and the samples. However, this method and its high-frequency variants require two types of samples with very specific geometries and sizes. This method is unsuitable for certain types of nanomaterials due to their complex mechanization at such undersized scales. This contribution proposes an alternative SE measurement method based on an absorber box that mitigates the problems presented by the ASTM D4935-18 standard. The SE of rigid nanomaterial samples based on several concentrations of multi-walled carbon nanotubes (MWCNT) and two different fiber reinforcements have been obtained.
Improved Differential Evolution Algorithm for Slab Allocation and Hot-Rolling Scheduling Integration Problem
Authors: Song Lulu , Meng Ying , Guo Qingxin , Gong Xinchang
Published: April 2023

To reduce logistics scheduling costs and energy consumption, this paper studies the slab allocation and hot-rolling scheduling integrated optimization problem that arises in practical iron and steel enterprises. In this problem, slabs are first allocated to orders and then sent to heating furnaces for heating; then, they are sent to a hot-rolling mill for rolling. A 0–1 integer programming model is established to minimize the attribute difference in the allocation cost between slabs and orders, the switching cost of hot-rolling processing, and waiting times after slabs reach rolling mills. Given the problem’s characteristics, an improved differential evolution algorithm using a real-number coding method is designed to solve it. Three different heuristic algorithms are proposed to improve the quality of solutions in the initial population. Multiple parent individuals participate in the mutation operation, which increases the population diversity and prevents the algorithm from falling into the local optimum prematurely. Experiments on 14 sets of real production data from a large domestic iron and steel plant show that our improved differential evolution algorithm generates significantly better solutions in a reasonable amount of time compared with CPLEX, the simulated artificial method, and the classical differential evolution algorithm, and it can be used by practitioners.
Diatom-Based Nanomedicine for Colorectal Cancer Treatment: New Approaches for Old Challenges
Authors: Tramontano Chiara , De Stefano Luca , Rea Ilaria
Published: April 2023

Colorectal cancer is among the most prevalent and lethal cancers globally. To address this emergency, countries have developed diffuse screening programs and innovative surgical techniques with a consequent decrease in mortality rates in non-metastatic patients. However, five years after diagnosis, metastatic CRC is still characterized by less than 20% survival. Most patients with metastatic CRC cannot be surgically treated. For them, the only option is treatment with conventional chemotherapies, which cause harmful side effects in normal tissues. In this context, nanomedicine can help traditional medicine overcome its limits. Diatomite nanoparticles (DNPs) are innovative nano-based drug delivery systems derived from the powder of diatom shells. Diatomite is a porous biosilica largely found in many areas of the world and approved by the Food and Drug Administration (FDA) for pharmaceutical and animal feed formulations. Diatomite nanoparticles with a size between 300 and 400 nm were shown to be biocompatible nanocarriers capable of delivering chemotherapeutic agents against specific targets while reducing off-target effects. This review discusses the treatment of colorectal cancer with conventional methods, highlighting the drawbacks of standard medicine and exploring innovative options based on the use of diatomite-based drug delivery systems. Three targeted treatments are considered: anti-angiogenetic drugs, antimetastatic drugs, and immune checkpoint inhibitors.
Comparison of C-Arm-Free Oblique Lumbar Interbody Fusion L5-S1 (OLIF51) with Transforaminal Lumbar Interbody Fusion L5-S1 (TLIF51) for Adult Spinal Deformity
Authors: Tanaka Masato , Sonawane Sumeet , Meena Umesh , Lu Zhichao , Fujiwara Yoshihiro , Taoka Takuya , Uotani Koji , Oda Yoshiaki , Sakaguchi Tomoyoshi , Arataki Shinya
Published: April 2023

Background and Objectives: Adult spinal deformity (ASD) surgery, L5-S1 lordosis is very important factor. The main objective of the research is to retrospectively compare symptomatic presentation and radiological presentation in the sequelae of oblique lumbar inter-body spinal fusion at L5-S1 (OLIF51) and transforaminal lumbar interbody fusion (TLIF) for ASD. Materials and Methods: We retrospectively evaluated 54 patients who underwent corrective spinal fusion for ASD between October 2019 and January 2021. Thirteen patients underwent OLIF51 (average 74.6 years old, group O) and 41 patients underwent TLIF51 (average 70.5 years old, group T). Mean follow-up period was 23.9 months for group O and 28.9 months for group T, ranging from 12 to 43 months. Clinical and radiographic outcomes are assessed using values including visual analogue scale (VAS) for back pain and Oswestry disability index (ODI). Radiographic evaluation was also collected preoperatively and at 6, 12, and 24 months postoperatively. Results: Surgical time in group O was less than that in group T (356 min vs. 492 min, p = 0.003). However, intraoperative blood loss of both groups were not significantly different (1016 mL vs. 1252 mL, p = 0.274). Changes in VAS and ODI were similar in both groups. L5-S1 angle gain and L5-S1 height gain in group O were significantly better than those of group T (9.4° vs. 1.6°, p = 0.0001, 4.2 mm vs. 0.8 mm, p = 0.0002). Conclusions: Clinical outcomes were not significantly different in both groups, but surgical time in OLIF51 was significantly less than that in TLIF51. The radiographic outcomes showed that OLIF51 created more L5-S1 lordosis and L5-S1 disc height compared with TLIF 51.
Effect of CaO-MgO-FeO-SiO2-xNa2O Slag System on Converter Dephosphorization
Authors: Geng Bin , Zhan Dongping , Jiang Zhouhua , Yang Yongkun
Published: April 2023

Na2O is an alkaline oxide, which can significantly improve the dephosphorization ability of converter slag. The effect of Na2O on the dephosphorization of converter slag was analyzed with a high-temperature dephosphorization experiment in a MoSi2 resistance furnace. We found that the dephosphorization rate increased with the increase of (Na2O) in the dephosphorization slag. The elements of Ca, Si, O, and P in the dephosphorization slag are distributed in the same area, mainly in the form of phosphate minerals, such as Ca2SiO4·0.05Ca3(PO4)2 and 6Ca2SiO4·Ca3(PO4)2. After adding Na2O, part of the Na will replace the Ca in the phosphorus-containing phase to form Ca2SiO4·Ca2Na2(PO4)2. The industrial test showed that the average dephosphorization rate in the early stage of the test heats with the CaO-MgO-FeO-SiO2-0.5%Na2O slag system could reach 62.39%, which was 19.62% higher than that of the conventional heats. The average basicity of the final slag was 0.19% lower than that of the conventional heats, while w(P2O5) increased by 0.36%, and T.Fe decreased by 0.69%. The average consumption of the slagging materials was 35.93 kg/t, which was 7.24 kg/t less than that of the conventional heats. Through thermodynamic calculation, we found that with the increase of (Na2O), the phosphorus distribution ratio between slag and steel increased significantly, the area of the liquid phase zone of the slag system increased continuously, and the viscosity decreased continuously.
Understanding the ADHD-Gut Axis by Metabolic Network Analysis
Authors: Taş Ezgi , Ülgen Kutlu O.
Published: April 2023

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder diagnosed with hyperactivity, impulsivity, and a lack of attention inconsistent with the patient’s development level. The fact that people with ADHD frequently experience gastrointestinal (GI) dysfunction highlights the possibility that the gut microbiome may play a role in this condition. The proposed research aims to determine a biomarker for ADHD by reconstructing a model of the gut-microbial community. Genome-scale metabolic models (GEM) considering the relationship between gene-protein-reaction associations are used to simulate metabolic activities in organisms of gut. The production rates of dopamine and serotonin precursors and the key short chain fatty acids which affect the health status are determined under three diets (Western, Atkins’, Vegan) and compared with those of healthy people. Elasticities are calculated to understand the sensitivity of exchange fluxes to changes in diet and bacterial abundance at the species level. The presence of Bacillota (genus Coprococcus and Subdoligranulum), Actinobacteria (genus Collinsella), Bacteroidetes (genus Bacteroides), and Bacteroidota (genus Alistipes) may be possible gut microbiota indicators of ADHD. This type of modeling approach taking microbial genome-environment interactions into account helps us understand the gastrointestinal mechanisms behind ADHD, and establish a path to improve the quality of life of ADHD patients.
A User-Centric 3D-Printed Modular Peristaltic Pump for Microfluidic Perfusion Applications
Authors: A. Cataño Jorge , Farthing Steven , Mascarenhas Zeus , Lake Nathaniel , Yarlagadda Prasad K. D. V. , Li Zhiyong , Toh Yi-Chin
Published: April 2023

Microfluidic organ-on-a-chip (OoC) technology has enabled studies on dynamic physiological conditions as well as being deployed in drug testing applications. A microfluidic pump is an essential component to perform perfusion cell culture in OoC devices. However, it is challenging to have a single pump that can fulfil both the customization function needed to mimic a myriad of physiological flow rates and profiles found in vivo and multiplexing requirements (i.e., low cost, small footprint) for drug testing operations. The advent of 3D printing technology and open-source programmable electronic controllers presents an opportunity to democratize the fabrication of mini-peristaltic pumps suitable for microfluidic applications at a fraction of the cost of commercial microfluidic pumps. However, existing 3D-printed peristaltic pumps have mainly focused on demonstrating the feasibility of using 3D printing to fabricate the structural components of the pump and neglected user experience and customization capability. Here, we present a user-centric programmable 3D-printed mini-peristaltic pump with a compact design and low manufacturing cost (~USD 175) suitable for perfusion OoC culture applications. The pump consists of a user-friendly, wired electronic module that controls the operation of a peristaltic pump module. The peristaltic pump module comprises an air-sealed stepper motor connected to a 3D-printed peristaltic assembly, which can withstand the high-humidity environment of a cell culture incubator. We demonstrated that this pump allows users to either program the electronic module or use different-sized tubing to deliver a wide range of flow rates and flow profiles. The pump also has multiplexing capability as it can accommodate multiple tubing. The performance and user-friendliness of this low-cost, compact pump can be easily deployed for various OoC applications.
Using Nanomaterials for SARS-CoV-2 Sensing via Electrochemical Techniques
Authors: Tieu My-Van , Le Hien T. Ngoc , Cho Sungbo
Published: April 2023

Advancing low-cost and user-friendly innovations to benefit public health is an important task of scientific and engineering research. According to the World Health Organization (WHO), electrochemical sensors are being developed for low-cost SARS-CoV-2 diagnosis, particularly in resource-limited settings. Nanostructures with sizes ranging from 10 nm to a few micrometers could deliver optimum electrochemical behavior (e.g., quick response, compact size, sensitivity and selectivity, and portability), providing an excellent alternative to the existing techniques. Therefore, nanostructures, such as metal, 1D, and 2D materials, have been successfully applied in in vitro and in vivo detection of a wide range of infectious diseases, particularly SARS-CoV-2. Electrochemical detection methods reduce the cost of electrodes, provide analytical ability to detect targets with a wide variety of nanomaterials, and are an essential strategy in biomarker sensing as they can rapidly, sensitively, and selectively detect SARS-CoV-2. The current studies in this area provide fundamental knowledge of electrochemical techniques for future applications.
Textile Bandwidth-Enhanced Polarization-Reconfigurable Half-Mode Substrate-Integrated Cavity Antenna
Authors: Liu Feng-Xue , Cui Jie , Meng Fan-Yu , Jiang Tian-Yu , Yan Shao-Fei , Chao Shuai , Zhao Lei
Published: April 2023

A textile bandwidth-enhanced polarization-reconfigurable half-mode substrate-integrated cavity antenna was designed for wearable applications. A slot was cut out from the patch of a basic textile HMSIC antenna to excite two close resonances to form a wide −10 dB impedance band. The simulated axial ratio curve indicates the linear and circular polarization of the antenna radiation at different frequencies. Based on that, two sets of snap buttons were added at the radiation aperture to shift the −10 dB band. Therefore, a larger frequency range can be flexibly covered, and the polarization can be reconfigured at a fixed frequency by switching the state of snap buttons. According to the measured results on a fabricated prototype, the −10 dB impedance band of the proposed antenna can be reconfigured to cover 2.29~2.63 GHz (13.9% fractional bandwidth), and the circular/linear polarization radiation can be observed at 2.42 GHz with buttons OFF/ON. Additionally, simulations and measurements were carried out to validate the design and to study the effects of human body and bending conditions on the antenna performance.
Numerical Study on Characteristics of Convection and Temperature Evolution in Microchannel of Thermal Flowmeter
Authors: Che Hang , Xu Qingxuan , Xu Guofeng , Fu Xinju , Wang Xudong , He Naifeng , Zhu Zhiqiang
Published: April 2023

During practical usage, thermal flowmeters have a limited range of applications. The present work investigates the factors influencing thermal flowmeter measurements and observes the effects of buoyancy convection and forced convection on the flow rate measurement sensitivity. The results show that the gravity level, inclination angle, channel height, mass flow rate, and heating power affect the flow rate measurements by influencing the flow pattern and the temperature distribution. Gravity determines the generation of convective cells, while the inclination angle affects the location of the convective cells. Channel height affects the flow pattern and temperature distribution. Higher sensitivity can be achieved with smaller mass flow rates or higher heating power. According to the combined influence of the aforementioned parameters, the present work investigates the flow transition based on the Reynolds number and the Grashof number. When the Reynolds number is below the critical value corresponding to the Grashof number, convective cells emerge and affect the accuracy of flowmeter measurements. The research on influencing factors and flow transition presented in this paper has potential implications for the design and manufacture of thermal flowmeters under different working conditions.
Laser Welding of Fiber and Quartz Glass Ferrule
Authors: Wang Wenhua
Published: April 2023

Optical fiber sensors fabricated by bonding have several limitations. To address these limitations, a CO2 laser welding process for an optical fiber and quartz glass ferrule is proposed in this study. A deep penetration welding method with optimal penetration (penetrating the base material only) is presented to weld a workpiece according to the requirements of the optical fiber light transmission, size characteristics of the optical fiber, and the keyhole effect of the deep penetration laser welding. Moreover, the influence of laser action time on the keyhole penetration is studied. Finally, laser welding is performed with a frequency of 24 kHz, power of 60 W, and duty cycle of 80% for 0.9 s. Subsequently, the optical fiber is subjected to out-of-focus annealing (0.83 mm, 20% duty cycle). The results show that deep penetration welding produces a perfect welding spot and has good quality; the hole generated from deep penetration welding has a smooth surface; the fiber can bear a maximum tensile force of 1.766 N. The performance of the optical fiber sensor is stable, and the maximum pressure deviation corresponding to the cavity length fluctuation is about 7.2 Pa. Additionally, the linear correlation coefficient R of the sensor is 0.99998.
Impact of Chlorine Dioxide on Pathogenic Waterborne Microorganisms Occurring in Dental Chair Units
Authors: Krüger Theresa Isabella Maria , Herzog Susann , Mellmann Alexander , Kuczius Thorsten
Published: April 2023

Bacterial contamination is a problem in dental unit water lines with the consequence of implementing regular disinfection. In this study, the short-term impact of chlorine dioxide (ClO2) treatment was investigated on the microorganisms Legionella pneumophila and L. anisa, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. The environmental background was proven as an important factor regarding the tolerance to 0.4 mg/L ClO2 as saline and phosphate-buffered saline resulted in a higher bacterial reduction than tap water. Gram-positive microorganisms demonstrated higher robustness to ClO2 than Gram-negative, and microorganisms adapted to tap water showed increased stability compared to cultured cells. At high densities, substantial numbers of bacteria were able to withstand disinfection, whereby the use of 4.6 mg/L ClO2 increased the inactivation rate. A massive cell decrease occurred within the first 5 minutes with subsequent plateau formation or slowed cell reduction upon further exposure. This biphasic kinetics cannot be explained by a ClO2 depletion effect alone, because the probability of bacterial subpopulations with increased tolerance should be taken into account, too. Our results prove high disinfection efficiency to microorganisms that were rather found in correlation to the level of bacterial contamination and background solutions than the chosen concentration for ClO2 treatment itself.
Rapid Monitoring of Viable Genetically Modified Escherichia coli Using a Cell-Direct Quantitative PCR Method Combined with Propidium Monoazide Treatment
Authors: Qin Yang , Qu Bo , Lee Bumkyu
Published: April 2023

The commercialization of industrial genetically modified microorganisms (GMMs) has highlighted their impact on public health and the environment. Rapid and effective monitoring methods detecting live GMMs are essential to enhance current safety management protocols. This study aims to develop a novel cell-direct quantitative polymerase chain reaction (qPCR) method targeting two antibiotic-resistant genes, KmR and nptII, conferring resistance against kanamycin and neomycin, along with propidium monoazide, to precisely detect viable Escherichia coli. The E. coli single-copy taxon-specific gene of D-1-deoxyxylulose 5-phosphate synthase (dxs) was used as the internal control. The qPCR assays demonstrated good performance, with dual-plex primer/probe combinations exhibiting specificity, absence of matrix effects, linear dynamic ranges with acceptable amplification efficiencies, and repeatability for DNA, cells, and PMA-treated cells targeting KmR/dxs and nptII/dxs. Following the PMA-qPCR assays, the viable cell counts for KmR-resistant and nptII-resistant E. coli strains exhibited a bias% of 24.09% and 0.49%, respectively, which were within the acceptable limit of ±25%, as specified by the European Network of GMO Laboratories. This method successfully established detection limits of 69 and 67 viable genetically modified E. coli cells targeting KmR and nptII, respectively. This provides a feasible monitoring approach as an alternative to DNA processing techniques to detect viable GMMs.