bluuebunny/crossref_metadata_2025 huggingface dataset:
The Roles of Neutrophils in Cytokine Storms
Authors: Chan Lily , Karimi Negar , Morovati Solmaz , Alizadeh Kasra , Kakish Julia E. , Vanderkamp Sierra , Fazel Fatemeh , Napoleoni Christina , Alizadeh Kimia , Mehrani Yeganeh , Minott Jessica A. , Bridle Byram W. , Karimi Khalil
Published: November 2021

A cytokine storm is an abnormal discharge of soluble mediators following an inappropriate inflammatory response that leads to immunopathological events. Cytokine storms can occur after severe infections as well as in non-infectious situations where inflammatory cytokine responses are initiated, then exaggerated, but fail to return to homeostasis. Neutrophils, macrophages, mast cells, and natural killer cells are among the innate leukocytes that contribute to the pathogenesis of cytokine storms. Neutrophils participate as mediators of inflammation and have roles in promoting homeostatic conditions following pathological inflammation. This review highlights the advances in understanding the mechanisms governing neutrophilic inflammation against viral and bacterial pathogens, in cancers, and in autoimmune diseases, and how neutrophils could influence the development of cytokine storm syndromes. Evidence for the destructive potential of neutrophils in their capacity to contribute to the onset of cytokine storm syndromes is presented across a multitude of clinical scenarios. Further, a variety of potential therapeutic strategies that target neutrophils are discussed in the context of suppressing multiple inflammatory conditions.
COVID-19 Vaccine Hesitancy and Attitude toward Booster Doses among US Healthcare Workers
Authors: Pal Suman , Shekhar Rahul , Kottewar Saket , Upadhyay Shubhra , Singh Mriganka , Pathak Dola , Kapuria Devika , Barrett Eileen , Sheikh Abu Baker
Published: November 2021

Vaccine reluctance among healthcare workers (HCW) can have widespread negative ramifications, including modeling behavior for the general population and challenges with maintaining a healthy workforce so we can respond to a resurgence of the pandemic. We previously reported that only one-third of HCW were willing to take the vaccine as soon as it became available prior to its Emergency Use Authorization (EUA). Here, we re-examine the attitude toward COVID-19 vaccines among HCW several months after the vaccines have been made widely available. In this study, only 7.9% (n = 107) of respondents were hesitant to take the first or second dose of the vaccine. Younger age (18–40 years) and lower level of education attainment (GED or less) were associated with higher vaccine hesitancy, whereas self-identified Asian racial identity was associated with greater acceptance of COVID-19 vaccination. Among the vaccine-hesitant group, more respondents noted mistrust of regulatory authorities (45.3%), government (48.6%), and pharmaceutical companies (50%) than mistrust of doctors (25.4%). Nearly two-thirds of respondents were concerned that vaccination may be ineffective against new strains and booster doses may be required; however, vaccine-hesitant respondents’ acceptance of a hypothetical booster dose was only 14.3%. Overall, vaccine hesitancy was observed to have demographic predictors similar to those previously reported; the hesitancy of some US HCW to receive booster doses may reflect a general hesitancy to receive other forms of vaccination.
SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody
Authors: Jugler Collin , Sun Haiyan , Chen Qiang
Published: November 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has caused more than 4.5 million deaths worldwide. Severe and fatal cases of COVID-19 are often associated with increased proinflammatory cytokine levels including interleukin 6 (IL-6) and acute respiratory distress syndrome. In this study, we explored the feasibility of using plants to produce an anti-IL-6 receptor (IL-6R) monoclonal antibody (mAb) and examined its utility in reducing IL-6 signaling in an in vitro model, which simulates IL-6 induction during SARS-CoV-2 infection. The anti-IL6R mAb (IL6RmAb) was quickly expressed and correctly assembled in Nicotiana benthamiana leaves. Plant-produced IL6RmAb (pIL6RmAb) could be enriched to homogeneity by a simple purification scheme. Furthermore, pIL6RmAb was shown to effectively inhibit IL-6 signaling in a cell-based model system. Notably, pIL6RmAb also suppressed IL-6 signaling that was induced by the exposure of human peripheral blood mononuclear cells to the spike protein of SARS-CoV-2. This is the first report of a plant-made anti-IL-6R mAb and its activity against SARS-CoV-2-related cytokine signaling. This study demonstrates the capacity of plants for producing functionally active mAbs that block cytokine signaling and implies their potential efficacy to curb cytokine storm in COVID-19 patients.
Anti-Spike SARS-CoV-2 IgG Assessment with a Commercial Assay during a 4-Month Course after COVID-19 Vaccination
Authors: Swadźba Jakub , Anyszek Tomasz , Panek Andrzej , Martin Emilia
Published: November 2021

We intended to assess the humoral response induced by the Pfizer/BioNTech Comirnaty COVID-19 vaccine with commercially available immunoassays: anti-spike (S) IgG and IgM, and anti-nucleocapsid (N) IgG antibodies, over a 4-month course. One hundred subjects, including 15 COVID-19 convalescents, comprised the study cohort. The SARS-CoV-2 antibodies concentrations were measured on day 0′ and 10′, 20′, 30′, 60′, 90′, and 120′ after the first dose administration. Over the course of the study, 100% of the participants developed and sustained anti-SARS-CoV-2 S IgG antibodies. The highest concentration, exceeding the quantification range of the test (2080 BAU/mL), was reached by 67% of the subjects on day 30′. The concentration of the antibodies remained stable between days 30′ and 90′ but was followed by a significant decrease between days 90′ and 120′. The stronger and more persistent humoral response was noted for women. The COVID-19 convalescents developed higher antibody levels, particularly 10 days after the first Comirnaty dose. Twenty-three out of the eighty-five naïve vaccinees failed to develop a detectable IgM response. LIAISON® SARS-CoV-2 TrimericS IgG (DiaSorin S.p.A, Saluggia, Italy) may be useful in the assessment of the humoral response to the Comirnaty vaccine. In contrast, Abbott’s anti-S SARS-CoV-2 IgM has a limited utility in this context.
The Cost-Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine in Seven Chinese Cities
Authors: Li Yan , Wang Huaqing , Furnback Wesley , Wang Bruce C. M. , Zhu Shuiqing , Dong Peng
Published: November 2021

Objective: This study estimates the cost-effectiveness of vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) among infants in Beijing, Shanghai, Shenzhen, Chengdu, Karamay, Qingdao, and Suzhou. Methods: A previously published cost-effectiveness model comparing vaccination with PCV13 to no vaccination was localized to the included Chinese cities. A systematic literature review was undertaken to identify age-specific incidence rates for pneumococcal bacteremia, pneumococcal meningitis, pneumonia, and otitis media (AOM). Age-specific direct medical costs of treating the included pneumococcal diseases were taken from the Chinese Health Insurance Association database. The base case analysis evaluated vaccine efficacy using direct effect and indirect effects (DE+ IDE). A subsequent scenario analysis evaluated the model outcomes if only DE was considered. A vaccination rate of 70% was used. The model reported outcomes over a one-year period after it was assumed the vaccine effects had reached a steady state (5–7 years after vaccine introduction) to include the direct and indirect effects of vaccination. Health outcomes were discounted at 5% during the steady-state period. Results: Vaccination with PCV13 was cost-effective in the base case analysis for all included cities with the incremental cost-effectiveness ratio (ICER) ranging from 1145 CNY(Shenzhen) to 15,422 CNY (Qingdao) per quality-adjusted life-year (QALY) gained. PCV13 was the dominant strategy in Shanghai with lower incremental costs and higher incremental QALYs. PCV13 remained cost-effective in the DE-only analysis with all ICERs falling below a cost-effectiveness threshold of three times GDP per capita in each city. Conclusions: Vaccination with PCV13 was a cost-effective strategy in the analyzed cities for both the DE-only and DE + IDE analyses. PCV13 became very cost-effective when a vaccination rate was reached where IDE is observed.
Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea
Authors: Lee Sang-Kyu , Park Dongsun , Lee Inhyung
Published: November 2021

Equine parvovirus-hepatitis (EqPV-H) causes equine hepatitis. The prevalence of EqPV-H in healthy horses has been reported in the United States, China, Germany, and Austria. The present study determined the prevalence of EqPV-H in the sera of clinically healthy horses in South Korea to identify the potential factors for infection and examine the genetic diversity of EqPV-H DNA sequences through comparison with foreign strains. Serum samples collected from 321 horses were tested for EqPV-H using non-structural protein 1 (NS1)-specific polymerase chain reaction. The associations of EqPV-H infection with sex, age, aspartate aminotransferase and γ-glutamyl transferase levels, and race performance were analyzed. Fourteen samples tested positive for EqPV-H (4.4%, 14/321), and EqPV-H infection was associated with sex (p = 0.006) and performance (p = 0.049). In both EqPV-H-positive and control horses, liver-specific biochemical analytes were within the normal ranges. Phylogenetic analyses based on the partial sequences of EqPV-H NS1 revealed that the Korean EqPV-H isolates shared approximately 98.7–100% similarity. Of these, 11 Korean isolates shared high similarity with strains from the United States, Germany, and China, and the remaining three strains were distinct in phylogenetic analyses. The present study describes the current molecular prevalence, potential risk factors, and genetic diversity of Korean EqPV-H.
Simultaneous Recovery of Struvite and Irrigation Water for Agricultural Purposes Obtained from Dewatering Liquor through Electrodialysis
Authors: Malíková Petra , Calábková Katrin , Heviánková Silvie , Halfar Jan , Kotalová Iva , Valová Barbora
Published: November 2021

Wastewater contains resources, which can be recovered for secondary use if treated properly. Besides research in zero liquid discharge solutions, the aim of the study was a simultaneous recovery of products from a wastewater treatment plant’s dewatering liquor. To be specific, we investigated a simultaneous recovery of struvite and irrigation water using electrodialysis (ED) in laboratory experiments. Two products were obtained from ED—concentrate and diluate. The concentrate was precipitated to obtain struvite. On average, 11 g of wet precipitate (including 17.58% of dry solids) were obtained from 1 L of concentrate. Crystal phases were confirmed by powder X-ray diffraction (XRD), with showing 94–97% recovery of struvite, while the remaining 3–6% were identified as hazenite. The average yield of crystal struvite was 1.76 g. Both struvite and hazenite may further be used as a fertilizer. Next, we suggest using the second ED product, the diluate, as irrigation water if it meets the irrigation water requirements. Attention was paid to the concentrations of dissolved solids (DS) in diluate, which decreased by an average of 93% compared to the input values in the dewatering liquor. In line with the observed Czech or EU standards indicators, we can say that the diluate can be used in agriculture, namely as irrigation water (Category I—water suitable for irrigation).
Modeling Local Scour around a Cylindrical Pier with Circular Collar with Tilt Angles (Counterclockwise around the Direction of the Channel Cross-Section) in Clear-Water
Authors: Qi Hongliang , Tian Weiping , Zhang Haochi
Published: November 2021

This research explores how a circular collar with a tilt angle (counterclockwise around the direction of the channel cross-section) could affect the local scour depth around a single cylindrical pier in clear-water based on Large Eddy Simulation (LES) in six cases. The results show that a horizontal circular collar is the best for reducing the local scour depth. With the increases of the tilt angle, the effect on reducing the local scour depth decreases gradually and is even counterproductive at the scour equilibrium. At the early stage of scouring, cases with circular collars show obvious scouring depth reductions. The smaller the tilt angle is, the better and longer-lasting the protection that the circular collar can provide. When the tilt angle is smaller than 5°, the location of the maximum local scouring is around 90–115° (the angle is measured clockwise from the flow direction) on both sides of the pier. When the tilt angle is greater than 5°, the depth of local scouring in the range around −115° to 115° is close to the maximum local scouring depth. Significantly larger areas reach the maximum scouring depth when the tilt angle increases. Compared to Case 1 (the pier without a circular collar), in the cases with a circular collar, the topographies downwards the pier in 1.0D (D is the diameter of the bridge pier) are changed to siltation from scouring. The topography downwards the pier changes from scouring to siltation with the increase of the tilt angle, and the shape of siltation changes from a long-narrow rectangle to an equilateral triangle. This study may provide valuable insights into the protection of the local scour of the pier.
Imposition of Restrictions on Payments with Cash Breaks the Principle of Proportionality of the Law
Authors:   The Corporate and Project Management Institute (Moscow), Lutsenko Sergej I. ,   Institute for Economic Strategies
Published: November 2021

The author considers the initiative from the Ministry of Finance of the Russian Federation about restriction of payments with cash from citizens. The argument of imposition of restrictions from the Ministry of Finance is stimulation of non-cash payments and also the method of fight against doubtful transactions. The similar initiative is contrary to peremptory rules of the Constitution of the Russian Federation, the civil law of the Russian Federation, also to the consumer protection law.
On Catastrophic Increase in Mortality and Measures to Save the People in Russia
Authors:   Russian Presidential Academy of National Economy and Public Administration, Aganbegyan Abel G.
Published: November 2021

How is it that in Russia, unlike in other countries, during the coronavirus pandemic the total mortality increased by a record amount and the income and consumption of the population decreased to the greatest extent? The point is that the crisis, caused by the coronavirus pandemic, is completely different from previous ones. It highlights the dilemma: should we use forces and means to prevent an economic recession with lower costs for anti-crisis measures, or focus on saving people's lives while minimizing additional mortality and maintaining real incomes of the population? Each country, depending on objectives, prevailing conditions and opportunities, chooses its “golden mean”. In many cases such choice is not fully conscious, since it's not possible to forecast with any certainty even over the near term. Decisions have to be taken up along the way, based on the situation and assessing the probability of certain events, including in view of the other countries' experience in combating the pandemic.
Olympic Games as a Way to Evaluate the Mobilization (Strategic) Resources of the Country
Authors:   International Research Institute for Advanced Systems, Pereslegin Sergei B.
Published: November 2021

Team success at the Olympic Games is a combination of material, demographic and cultural factors with non-material factors — will, fighting spirit, passion, patriotism. Exactly the same combination of factors determines the ability of a state to wage a war. Therefore, military capabilities of the state (as well as economic and technological ones), according to the author, can be assessed by results at the Olympic Games.
The Safety of Benzodiazepines and Opioids in the Geriatric Population: An Analysis of Patient Safety Events Reported by Hospitals and Ambulatory Surgical Facilities
Authors: Kukielka Elizabeth
Published: November 2021

Benzodiazepines may increase the risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes in patients 65 years and older. The concomitant use of benzodiazepines and opioids may also be inappropriate for older adults due to the increased risk of overdose. We searched the Pennsylvania Patient Safety Reporting System (PA-PSRS) for reports of patient safety events related to the concomitant use of benzodiazepines and opioids in older adults in order to gain a better understanding of the potential risks of using these medications in combination. We identified 80 reports in which a patient may have experienced an adverse drug reaction (ADR) to the combined use of a benzodiazepine and an opioid pain medication. Reports were reviewed to determine the ADR(s) experienced by the patient. Changes in mental status were most common, occurring in more than two-thirds of reports (68.8%; 55 of 80), followed by respiratory reactions (51.3%; 41 of 80) and cardiovascular reactions (25.0%; 20 of 80). In over two-thirds of reports (70.0%; 56 of 80), the patient received a reversal agent, either flumazenil (10.7%; 6 of 56) or naloxone (35.7%; 20 of 56), or both (53.6%; 30 of 56). The inappropriate use of benzodiazepines and opioid pain medications in combination among patients 65 years and older is a growing problem, and an increased awareness may be the first step for providers to begin addressing it.
Slow Down: New-Onset Atrial Fibrillation Challenges for Ambulatory Surgical Facilities
Authors: Motts Melanie , Gardner Lea Anne
Published: November 2021

As patient safety liaisons (PSLs), we are continually educating and collaborating with our Pennsylvania healthcare facilities. We often are asked questions about reportable events under the Medical Care Availability and Reduction of Error (MCARE) Act. One of the most common examples we discuss is cancellations and transfers out of an ambulatory surgical facility (ASF). The top three reasons for cancellations include preop instructions not followed, missed medical issues identified during preop screening, and no shows. The top three reasons for transfers include cardiac arrhythmias, aspiration, and hypertension. Interestingly, between discussions with facilities and review of event reports, new-onset atrial fibrillation (AF) has come up often as a common reason for cancellations or transfers out of the ASF setting, especially in gastrointestinal (GI) procedures. In fact, as PSLs, when educating ASFs on reportable events we often give the example of placing a patient on the cardiac monitor in preop and the patient is found to be in AF. In 2009, it was estimated that 13.1% of AF cases were undiagnosed,3 which may explain why patients are presenting with new-onset AF. People with AF are at an increased risk of complications (e.g., stroke);3,4 therefore, a cancellation or transfer may be necessary depending on the patient’s condition. These events are considered reportable to the Pennsylvania Patient Safety Reporting System (PA-PSRS) under MCARE.
Studi Tentang Game Usability Pada In-app Game Untuk Meningkatkan Engagement Pengguna E-commerce
Authors: Dinata Hendra , Angga Melissa
Published: November 2021

Maraknya perdagangan online di Indonesia memicu kebutuhan akan hadirnya strategi yang mampu mengadaptasi perkembangan TI secara lebih kreatif bagi suatu platform agar dapat lebih merangkul dan mengikat penggunanya. Salah satu strategi tersebut adalah dengan menghadirkan in-app game untuk menjaga agar pengguna dapat secara konsisten hadir dan mengakses platform tersebut. Efektivitas in-app game dalam meningkatkan engagement sangat bergantung pada usability dari In-app game itu sendiri, sehingga dalam penelitian ini akan disusun suatu evaluasi heuristik yang mempertimbangkan game usability dan juga teori flow untuk menguji user engagement pada game Shopee Candy. Objektif evaluasi tersebut meliputi 7 aspek yaitu ketersediaan mekanisme yang memudahkan pemain belajar dan menikmati alur permainan, kemudahan untuk dimainkan tetapi cukup menantang, kemudahan pemain mengenali tindakannya, grafis yang menarik, kemudahan akses, sisi mobilitas dan penambahan aspek ke-7 yaitu keterhanyutan pemain. Proses pengujian melibatkan sejumlah responden yang memiliki pengalaman bermain game Shopee Candy yang akan mengisi survei sesuai evaluasi heuristik yang telah disusun. Berdasarkan uji validitas terhadap setiap objektif, beberapa pertanyaan pada objektif pertama dan kedua dinyatakan tidak valid dengan nilai r di bawah 0,3. Kemudian berdasarkan uji reliabilitas pada setiap objektif, nilai Cronbach menunjukkan bahwa setiap objektif dapat diandalkan dengan objektif yang agak kurang adalah pada objektif grafis yang menarik dan kemudahan akses. Secara umum dapat disimpulkan game Shopee Candy berhasil menjalin user engagement yang terukur dari 7 aspek yang dievaluasi dan pengembang game perlu memberikan perhatian lebih dalam menyusun mekanisme yang dapat membantu pemain belajar dan memahami alur permainan serta kemudahan dalam kustomisasi dan mobilitas.
Implementasi Continous Integration/Continous Delivery Menggunakan Process Manager 2 (Studi Kasus: SIAKAD Akademi Keperawatan Bina Insan)
Authors: Danur Wijayanto  , Arizona Firdonsyah  , Faisal Dharma Adhinata
Published: November 2021

Pada perkembangan perangkat lunak yang semakin beragam dan kompleks, diperlukan fleksibilitas dan adaptasi terhadap proses pengembangan perangkat lunak. Konsep DevOps muncul dari permasalahan yang muncul antara developer dan operation. CI/CD dapat mendukung DevOps dikarenakan dapat mempercepat proses integrasi dan delivery perangkat lunak kepada pengguna. Dalam menerapkan CI/CD diperlukan tools pendukung seperti git sebagai source code control dan jenkins untuk membantu proses deployment. Penelitian yang dilakukan penulis menggunakan Process Manager 2 (PM2) untuk implementasi CI/CD pada sistem Sistem Informasi Akademik (SIAKAD) Akademi Keperawatan Bina Insan. Diharapkan penelitian ini berkontribusi untuk memperluas wawasan mengenai tools dalam mengimplementasikan CI/CD. Hasil menunjukkan implementasi CI/CD menggunakan GitHub Repository, Jenkins, dan PM2 berhasil dilakukan dan berjalan dengan baik. PM2 menunjukkan performa yang lebih baik daripada Docker jika dilihat dari segi waktu build dan penggunaan RAM. PM2 memerlukan waktu deployment 185 detik, 46% lebih cepat daripada Docker. Sedangkan penggunaam RAM PM2 sebesar 1,9 GB, 45% lebih sedikit daripada Docker.
Analisis Kinerja, Disiplin, dan Produktivitas Kerja Karyawan Dalam Mempengaruhi Pemanfaatan Sistem Informasi Sumber Daya Manusia
Authors: Wijonarko Gugus
Published: November 2021

Era digital secara konsep menuntut pemanfaatan teknologi pada seluruh aspek pekerjaan manusia, khususnya adanya sinergi dan hubungan antara teknologi dengan faktor manusia yang dianggap sebagai salah satu aset perusahaan. Tujuan penelitian ini adalah untuk mengukur dan mengetahui faktor-faktor yang membuat karyawan memutuskan untuk menggunakan aplikasi sistem informasi sumber daya manusia dalam rutinitas pekerjaan dengan melihat pada variabel penelitian manajemen SDM yaitu kinerja, disiplin, dan produktivitas kerja dalam mempengaruhi keputusan menggunakan aplikasi HRIS. Sampel penelitian ini adalah pengguna dari beberapa perusahaan di Surabaya yang menggunakan aplikasi HRIS dalam rutinitas operasional pekerjaan sehari-hari mereka. Pada penelitian ini ditemukan sampel penelitian sebanyak 55 responden dari berbagai perusahaan di Surabaya dan hasil tanggapan responden tersebut dilakukan pengolahan data menggunakan teknik analisis data regresi linear berganda dengan tingkat kepercayaan 95% dan pembuktian hipotesis menggunakan uji T dan uji F. Hasilnya adalah faktor kinerja karyawan dan faktor disiplin mempengaruhi secara signifikan keputusan pengguna menggunakan sistem informasi sumber daya manusia. Hal ini dikarenakan para responden merasa adanya urgensi terhadap proses pencatatan adminsitrasi yang lebih baik. Sedangkan untuk variabel produktivitas kerja tidak mempengaruhi keputusan penggunaan aplikasi SISDM dikarenakan aplikasi hanya dipandang sebagai alat penunjang operasional pekerjaan sehari hari.
GAMBARAN PENGAMBILAN KEPUTUSAN KLINIS DALAM P4K (PROGRAM PERENCANAAN PERSALINAN DAN PENCEGAHAN KOMPLIKASI) DI DAERAH PESISIR PANTAI AMAL LAMA TARAKAN
Authors: Alfianur Alfianur , Susanti Susanti , Padilah Rahmi , Purnamasari Agus
Published: November 2021

Latar Belakang: Perencanaan persalinan dan pencegahan komplikasi juga sangat penting untuk mencegah terjadinya keterlambatan penanganan komplikasi. Pengambilan keputusan adalah bagian yang kompleks, dipengaruhi oleh faktor individu, sosial, akses, dan sistem kesehatan. Pengakuan tepat waktu dari gejala, ketersediaan keuangan,  aksesibilitas fisik fasilitas kesehatan, dan persepsi kualitas pelayanan tentang pertimbangan  fasilitas rujukan yang diperlukan dalam membuat keputusan untuk mencari perawatan yang lebih baik. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh/dampak pendidikan kesehatan ibu hamil dan keluarga pada pengambilan keputusan klinis P4K (Program Perencanaan Persalinan dan Pencegahan Komplikasi)Metodologi: Penelitian ini menggunakan penelitian Deskriftif  tentang sikap ibu hamil dan keluarga mengenai Program Perencanaan Persalinan dan Pencegahan Komplikasi (P4K)Hasil: Hasil analisis data Univariat  terdapat bahwa 85% Responden telah menentukan tempat bersalin, 75% telah menentukan siapa yang akan menolong persalinan, 58 % mempersiapkan transportasi, 20% telah mempersiapkan donor darah, 90% telah mempersiapkan biaya. Gambaran ini  menunjukkan bahwa masih terdapat pengambilan klinis dalam P4K yang rendah terutama dalam persiapan donor darah dan persiapan transportasi. Banyak faktor yang mempengaruhi  sikap ibu hamil dan keluarga dalam pengambilan keputusan klinis P4KKata Kunci:  P4K, Ibu Hamil
PENGETAHUAN TENTANG COVID 19 MAHASISWA KEPERAWATAN UNIVERSITAS BORNEO TARAKAN
Authors: Alfianur Alfianur
Published: November 2021

Latar Belakang: Covid 19 merupakan penyakit infeksi saluran pernapasan yang disebabkan oleh corona virus, penyakit ini telah menjadi pandemik, mudahnya penularan penyakit ini menyebabkan hampir semua Negara di dunia mengalami wabah ini. Pencegahan penyakit corona visrus ini telah banyak disampaikan oleh WHO dan pemrintah seperti, mencuci tangan dengan sabun pada air yang mengalir, menutup wajah dengan Masker, menjaga jarak, membatasi aktifitas dengan dirumah saja. Keberhasilan pencegahan penyakit ini yang tergantung pada kedisiplinan dan kepatuhan masyarakat melaksanakan himbauan pemerintah Tujuan dari penelitian ini adalah untuk Menganalisis hubungan tingkat pengetahuan tentang Covid 19 dengan kepatuhan dalam melakukan Pencegahan Penyakit.Metodologi: Jenis penelitian ini adalah penelitian kuantitatif dengan desain Cross sectional. Sampel penelitian ini adalah Mahasiswa Jurusan Keperawatan. Menggunakan total sampling dan pengolahan data menggunakan pendekatan statistic deskriptif (distribusi frekuensi).Hasil: Hasil analisis data didapatkan reponden memiliki tingkat pengetahuan yang Baik sebanyak 113 orang(83%) sisanya memiliki pengetahuan ditingkat Cukup sebanyak 24 orang(17%). Kata Kunci:  Pengetahuan, Covid 19
HUBUNGAN ANTARA PENGETAHUAN TENTANG KEHAMILAN RESIKO TINGGI DAN TINGKAT DEPRESI PADA IBU HAMIL
Authors: Juwitasari Juwitasari , Marni Marni
Published: November 2021

Kehamilan resiko tinggi berdampak pada fisik berupa pendarahan pada ibu dan gangguan pertumbuhan janin. Dampak psikologisnya dapat terjadi gangguan mood atau depresi saat kehamilan. Tujuan penelitian ini adalah untuk mengetahui hubungan antara tingkat pengetahuan tentang kehamilan resiko tinggi dengan tingkat depresi pada ibu hamil. Penelitian analitik observasional ini menggunakan desain cross sectional. Pemilihan sampel menggunakan teknik quota sampling, berjumlah 35 orang ibu hamil di wilayah RT.05 Kelurahan Karang Ambun, Kecamatan Tanjung Redeb, Kabupaten Berau dengan rentang usia 17-40 tahun, dalam periode kehamilan trimester 1 dan trimester 2. Analisa data dilakukan dengan menggunakan Uji Korelasi Spearman. Hasil penelitian ini adalah mayoritas ibu hamil berusia 35 tahun (51,4%), dengan tingkat pendidikan SMA (60,0%), yang bekerja sebagai IRT (57,1%). Mayoritas ibu hamil memiliki jumlah anak hidup sebelum kehamilan sebanyak 2 orang sekitar (28,6%). Mayoritas merupakan kehamilan ke 3 sebanyak (28,6%), dan memiliki usia kandungan rata rata trimester II (74,2%). Hasil uji Korelasi Spearman didapatkan p value sebesar 0,003 (0,05) dengan koefisien korelasi sebesar -0,488 menunjukan ada korelasi negatif antara pengetahuan tentang kehamilan resiko tinggi dan tingkat depresi pada ibu hamil. Peningkatan pengetahuan ibu akan mempengaruhi sikap dan perilaku ibu selama masa kehamilan yang akan membuat ibu memiliki risiko depresi yang rendah.
The Effect Of Store Atmosphere On Purchase Decisions At Chirurgie Cafe And Books Medan
Authors: Sembiring Pramesco Wiranta
Published: November 2021

This research is motivated by the importance of store atmosphere in a cafe or shop, because now the price, discount, promotion and service do not become guarantee of consumer to make a purchase, but store atmosphere (good store atmosphere) will be the main attraction for cafe Who own it, so as to attract consumers to make a purchase.The purpose of this research is to know the influence of store exterior, general interior, store layout and interior display to purchase decision at Chirurgie Cafe and Books Medan.This research uses quantitative method with associative approach. The population in this study were all visitors of Chirurgie Cafe and Books Medan with sample size 100 people. The sampling technique in this research is done by using Non Probability Sampling technique with accidental sampling technique and purposive sampling. Analytical methods used are validity test, reliability test, t-test, f-test, classical assumption test, multiple linear regression analysis test, and coefficient of determination (R2) test.The result of this research shows that partially the result of store exterior variables is tcount (1,728)> ttable (1,6608) and probability value 0,087 <0,1, which means that store exterior (X1) has positive and significant effect to purchasing decisions). The general interior variables show that tcount (2.234)> ttable (1.6608) and probability value 0.028 <0.1, which means that general interior (X2) has positive and significant effect to purchase decision (Y). The store layout variable shows that tcount (2.2072)> ttable (1.6608) and probability value 0.041 <0.1, which means that store layout (X3) has positive and significant effect on purchase decision (Y). Exterior store variables show that tcount (0.397)> ttable (1.6608) and probability value 0.692 <0.1, which means that interior display (X4) has positive but not significant effect on purchasing decision (Y). Simultaneously the independent variable (free) shows that the fcount is 7.011 with the significance level 0.000, while the ftable at the 90% confidence level (α = 0.10) is 2.00. Then fcount (7.011)> ftable (2.00) and probability value 0.000

<0.10, which means all independent variables simultaneously affect the dependent variable.
Digital practice spaces and clinical practice in teacher preparation: Current uses and future possibilities
Authors: Littenberg-Tobias Joshua , Kaka Sarah , Kessner Taylor , Francis Anthony Tuf , Kennett Katrina , Reich Justin
Published: November 2021

This paper explores how the use of digital practice spaces (DPSs) can inform teacher preparation through a reimagining of clinical practice in teacher preparation by addressing the question: what roles might DPSs play in the ecology of apprenticeship opportunities for future educators? We leveraged AACTE’s Essential Proclamations and Tenets for Highly Effective Clinical Educator Preparation as an analytical framework to examine our own experiences using DPSs in our teacher education coursework. We discuss the alignment between these proclamations and the theoretical, conceptual, and practical underpinnings of DPSs. Finally, we consider the remaining proclamations that represent the horizons of DPSs within teacher preparation, a task we undertook as a set of informed provocations, envisioning how DPSs could be designed to support the proclamations not currently supported.
Craniectomía descompresiva como tratamiento primario de la hipertensión intracraneal por traumatismo encefalocraneano: Experiencia observacional en 24 pacientes.
Authors: León-Palacios José Luis , Carranza-Vásquez Abel Paul , Alaba-García Wesley , Lovatón Rolando
Published: November 2021

Introducción: el traumatismo encéfalo craneano es una de las principales causas de muerte en nuestro medio, El tratamiento médico y quirúrgico en la etapa inicial de un TEC severo se enfoca en evitar la elevación de la Presión Intracraneana. Objetivo: describir características asociados y sus principales complicaciones en aquellos pacientes sometidos a Craniectomía Descompresiva. Métodos: Estudio retrospectivo observacional descriptivo, realizado entre febrero de 2018 a julio de 2020 de pacientes operados de Craniectomía Descompresiva unilateral, admitidos por traumatismo encefalocraneano. Resultados: 66.7% fueron personas menores de 40 años; 87,5% fueron de sexo masculino; 16,7% de la población ingresaron con una ECG de 13-15, 37,5% de la población con una ECG de 9-12; 42.9% presentaron asimetría pupilar; 33,3% ingresaron por accidente de tránsito; 21,7% fueron Marshall II, 65,2% Marshall III y en 13,0% se halló un Marshall IV. Conclusiones: Los resultados sugieren que las características asociadas a la Craniectomía Descompresiva por TEC contribuyen en el manejo de esta patología.
liberdade é republicana e socialista
Authors: Guimarães Juarez Rocha , Gomes David Francisco Lopes , Campos Gabriel Afonso , Carvalho Yago Condé Ubaldo de
Published: November 2021

Professor do Departamento de Ciências Políticas da UFMG, Juarez Rocha Guimarães é um personagem de protagonismo na inteligência política brasileira e um intelectual que um conhecimento enciclopédico e um trato gentil. Modos republicanos, pode-se dizer. Se a república é a categoria fundamental do seu pensamento, Juarez Guimarães não deixou de tratar também de outros conceitos e teses que com ela se relacionam de alguma maneira com a ideia de república: modernidade, liberalismo, contracultura, liberalismo. Em uma agradável tarde que antecedeu o congresso 30 anos, e agora?, que viria a homenagear nosso entrevistado, recebemos Juarez na Faculdade de Direito e Ciências do Estado e tivemos uma conversa ao mesmo tempo rica e agradável. Esperamos que ela seja fonte de sabedoria também para os nossos leitores.
STRATEGI ZALORA INDONESIA MENGELOLA BISNIS FESYEN DI TENGAH PANDEMI
Authors: Hartanto Susi
Published: November 2021

Zalora strategies in the midst of pandemic are: 1) Expand 4 shopping categories (health & beauty, kids, luxury, home) and adding brands and network to 2 existing categories (fashion and sports); 2)Actively hold marketing campaign, especially related to tik-tok influencers and other online media, and keep maintain a small portion of offline campaigns; 3) Adding shopping features for customers in both desktop and mobile app versions; 4) Providing ease, rewards, and cashback for marketplace brands (there are 2 brand categories in Zalora Indonesia: catalog and marketplace, where marketplace holds a bigger percentage); 5) Empowering data-driven decisions for suppliers through Trender platform. From Zalora Indonesia internal data, this article is expected to provide useful information for fashion enthusiasts or academics about newest update in Indonesia fashion industry.
IMPLEMENTASI STRATEGI BERKELANJUTAN ZALORA ASIA TENGGARA
Authors: Hartanto Susi
Published: November 2021

Sebagai salah satu platform fesyen terbesar di Asia Tenggara, Zalora berkewajiban menjadi contoh pelaksanaan industri fesyen berkelanjutan yang telah lama menjadi isu di seluruh dunia. Artikel ini disusun melalui metode analisis deskriptif yang didapat dari data internal Zalora, beserta studi mandiri via situs terpercaya. Hasilnya, ada 13 inisiatif yang telah dilakukan Zalora dalam rencana berkelanjutan 2020-2025, yang terbagi dalam beberapa aspek seperti kemasan, pencarian sumber etis, pengukuran konsumsi energi dan jejak karbon, memulai circular fashion melalui kategori pre-loved dan earth edit, serta ikut dalam keterlibatan komunitas.
TARI JAIPONG SEBAGAI INSPIRASI DESAIN INTERIOR HOTEL DI BANDUNG
Authors: Virthadani Sherly
Published: November 2021

Globalization affects all aspects of people's lives, including changes in cultural values. This threatens the diversity and uniqueness of the existing local culture. In general, culture is more focused on universal form and uniformity. For this reason, efforts are needed to introduce and redevelop the cultural diversity of the local area. One of the strategies is to promote traditional culture as a source of inspiration in the interior design concept of a city hotel. This interior design uses the Jaipong Kawung Anten dance as a source of inspiration for City Hotel's interior design. The research method uses a qualitative method with a descriptive approach. Processing the design concept takes the character and philosophy of the Jaipong Kawung Anten dance. The Jaipong Kawung Anten dance tells the story of the daughter of Kawung Anten from the Sumedang Larang kingdom. The character of the dance is dynamic, varied, energetic, and masculine. The elements of the dance are implemented in the treatment of walls, floors, and the selection of furniture. Some elements of the Jaipong Kawung Anten dance are also processed into artwork and hotel interior ornaments. The choice of interior materials and colors also refers to the visualization of the Jaipong Kawung Anten dance. The results of this interior design are expected to become an iconic hotel in Bandung with the theme "Jaipong Kawung Anten". Through interior design, this can also be an effort to help preserve traditional Sundanese culture.
Indígenas urbanos e identidade: uma colaboração artística com os Wapichana
Authors: Ferreira Corrêa Antenor
Published: November 2021

Este artigo reflete sobre o conceito de identidade na perspectiva dos indígenas urbanos. Apresenta uma obra artística resultante da interação entre o autor e membros Wapichana, uma comunidade indígena brasileira. Após colaborar em manifestações, foi realizada uma intervenção artística que produziu uma videoarte. Essa obra  evidenciou diferentes vozes pertencentes a uma mesma comunidade indígena, mesclando tradição, modernidade e  distintas visões sobre questões semelhantes. Essa ação contribuiu para diminuir o preconceito contra os grupos indígenas e deu visibilidade a alguns de seus problemas. Essa interação participa de uma gama de intervenções artísticas que reivindicam mudanças sociais e políticas.
COMO VINHO E FERROVIA SE CONECTAM PARA O DESENVOLVIMENTO DO TURISMO?
Authors: Lavandoski Joice , Fraga Carla , Tonini Hernanda
Published: November 2021

O presente estudo indaga-se sobre uma interface específica: “Como vinho e ferrovia se conectam para contribuir para o desenvolvimento local e regional do turismo no Brasil?”. Portanto, o objetivo geral é analisar a relação entre vinho e ferrovia na perspectiva do desenvolvimento local e regional do turismo, considerando o Trem do Vinho “Maria Fumaça” na Região Uva e Vinho. O estudo é exploratório e descritivo, com levantamento bibliográfico e análise de dados secundários obtidos através de comentários (n=1.669) disponíveis no TripAdvisor sobre a Maria Fumaça referentes ao período de sete anos. Além da localização geográfica da área do estudo através do software QGis, foi possível elaborar análises textuais (Análise de Similitude e Nuvem de Palavras) utilizando-se do software Iramuteq. Os resultados contribuem para a perspectiva do desenvolvimento local e regional envolvendo conexões entre vinho, ferrovia e turismo, e para o avanço epistemológico sobre o que pode ser compreendido como turismo enoferroviário.
PERCEPÇÃO DA GESTÃO DE QUALIDADE EM HOTÉIS DE CAMPINA GRANDE/PB
Authors: Leal Kamilla Rafhaella De Andrade , Maracajá Kettrin Farias Bem
Published: November 2021

A gestão da qualidade do serviço aliada a percepção do cliente tende a gerar satisfação e consequentemente desenvolvimento do negócio, pois o nível de satisfação e expectativa do cliente permite que a organização descubra os seus pontos fortes e fracos, a fim melhorar seu posicionamento no mercado. Em vista disso, o objetivo do estudo consiste em analisar a percepção dos hóspedes em relação a qualidade dos serviços baseado no TOURQUAL, na cidade de Campina Grande/PB. Para isso, foi realizada uma pesquisa descritiva, subdividida em 3 etapas.Iniciou-se com a pesquisa exploratória bibliográfica e documental,posteriormente foi feita a coleta on-line de comentários de três hotéis da cidade na rede social de turismo, Booking, e por fim a análise de dados com o uso de netnografia. Os dados foram coletados entre Setembro de 2019 e Fevereiro de 2020, com amostra de 294 comentários on-line. Os resultados mostraram que os hotéis analisados foram satisfatórios, entretanto a gestão precisa reforçar os serviços de segurança e de entretenimento.
PUBLICIDADES TURÍSTICAS DO MAGREBE: (DES)CONTINUIDADES DO IMAGINÁRIO DA PINTURA ORIENTALISTA DO OITOCENTOS
Authors: Dazzi Camila , Loureiro Isabela Roque , Azevedo Suzana De Carvalho Barroso
Published: November 2021

O imaginário criado pela arte orientalista do século XIX ainda está presente nos anúncios turísticos hoje, como forma de despertar o desejo de conhecer o Oriente. No Oitocentos, o Norte da África, recorte geográfico enfocado neste estudo, passou a receber artistas e turistas, que, imersos em um contexto de violência e deslumbrados pelo exótico, ajudaram a moldar esse imaginário de um Oriente pitoresco e místico. A fim de compreender as (des) continuidades do imaginário orientalista da pintura oitocentista, tomamos como referencial teórico os conceitos de imaginário e Orientalismo dentro do contexto da invasão francesa e da colonização do Magrebe. A partir de uma análise comparativa formal de imagens utilizadas em anúncios turísticos, identificamos traços de grande poder visual e simbólico concernentes à arte orientalista do século XIX. Sendo assim, resultados apontam para uma permanência de certos elementos desta arte na publicidade turística atual sobre a região, o que pode sustentar uma visão colonial sobre o território em questão.
DIFICULDADES DE INDIVÍDUOS VEGANOS EM DESTINOS TURÍSTICOS
Authors: Lopes Mariana Da Silva , Gimenes-Minasse Maria Henriqueta
Published: November 2021

O veganismo é uma filosofia de vida que busca evitar a exploração de animais e crueldade contra eles, seja para fins de alimentação, vestuário ou outro propósito. Tal postura gera restrições diárias para seus praticantes, que podem ser agravadas em viagens. Este artigo tem como objetivo identificar e analisar, a partir de uma pesquisa exploratória, as principais dificuldades que veganos encontram ao planejar suas viagens, considerando a alimentação, a hospedagem e os atrativos oferecidos pelo destino. A amostra foi não probabilística e os fatores delimitantes foram: ter acesso à internet, ser usuário de redes sociais e ser vegano. Foram contabilizados 170 respondentes válidos. Dentre os resultados, destacam-se: entre os respondentes, há expressiva predominância (85,88%) daqueles que adotaram o veganismo recentemente; em relação à alimentação as  principais dificuldades compreendem encontrar opções veganas e estabelecimentos exclusivamente  veganos; em relação aos atrativos turísticos, a maior parte dos respondentes indicaram não haver dificuldade por se recusarem a participar de atividades que envolvam exploração animal; embora  uma parcela significativa (33,5%) tenha  dificuldade para encontrar atrativos que não envolvam exploração animal; em  relação a meios de hospedagem, 31,7% dos respondentes declararam não encontrar dificuldades, sendo que os demais apontaram dificuldades de encontrar opções alimentares (88 ocorrências). Conclui-se que, embora o veganismo compreenda qualquer forma de exploração animal para fins de alimentação, vestimenta, de higiene e beleza e de entretenimento, as dificuldades indicadas pelos respondentes correspondem principalmente ao plano alimentar.
Antimicrobial effects of essential oils from Tanacetum vulgare L. and Salvia officinalis L., growing in Slovakia
Authors: Mikulášová Mária , Vaverková Štefánia
Published: November 2021

Possible antimicrobial properties of essential oils isolated from Tanacetum vulgare L., and Salvia officinalis L., harvested from five different locations in Slovakia, were examined using the disc agar diffusion method and by the microdilution method. GC/MS analysis of the essential oil from Tanacetum vulgare L. resulted in the identification of 16 compounds constituting 82.1% of the total oil. Gram-positive bacteria, mainly Bacillus subtilis, were more susceptible to essential oils from both plants than were gramnegative species. Tested essential oils posses also anti-yeast activity. The shares of the constituents in the essential oils as well as their antimicrobial activity differed in dependence on the locality.
Wireless Power Transfer Device Based on RF Energy Circuit and Transformer Coupling Procedure
Authors: Karuppusamy P.
Published: November 2021

It is possible to transmit electricity wirelessly without the need for cables. Wireless power transmission makes it possible to link remote places that would otherwise be cut off from access to reliable electricity. A wireless connection to the power supply is expected in the future. This study describes the experimental results of Wireless Power Transfer (WPT) utilizing a transformer coupling approach and its future potential. This WPT device (WPTD) is used to transmit power using two procedures of energy transfer: radiofrequency coupling and transformer coupling, both of which are magnetic based, in principle. The distance between the transmitter and receiver of the system affects the amount of power that can be sent. Research is performed to establish how far apart the system's transmitter and receiver should be. Magnetic fields may transmit energy between two coils, but the distance between the two coils must be too close for this approach to work. Aside from that, it assesses the setting parameter of a value that has been tabulated using a certain application, in the findings and discussion parts.
Technological parameters of gas-dynamic spraying affecting the formation coating based on mixture of particles copper, zinc and corundum
Authors: Arhipov V.E. , Moskvitin G.V. , Pugachev M.S.
Published: November 2021

The results of a study of the effect of the spraying temperature and the overlap coefficient on the formation of the coating structure based on a mixture of Cu, Zn and Al2O3 particles applied by cold gas-dynamic spraying are presented. X-ray diffraction analysis has shown a decrease in the size of coherent scattering regions (CSR) from 200 nm to 90 nm for copper and to 64 nm for zinc when using an overlap coefficient of 55 % and more significant (up to 22 nm) with an overlap of 64 %. The CSR sizes of electronic type compounds CuZn3 (ε-phase) and Cu5 Zn8 (γ-phase) are quite close to the CSR size of zinc. The microdeformation of copper decreases from 187 to 119 % with an increase in the deposition temperature and does not depend on the overlap coefficient. For the electronic compound of the ε-phase, the microstrain value increases, and the γ-phase decreases by 2 times (from 0.31 to 0.17 %). The mass fraction of aluminum oxide (corundum) decreases from 5.4 to 2.2 % with an increase in the spraying temperature. The use of the maximum spraying temperature of 450 °C is accompanied by the formation of zinc oxide, the mass fraction of which is 4.3 % with 64 % overlap.