bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of Long-Term Geochemical Change in Bentonite Based on the Interpretative THMC Model of the FEBEX In Situ Test
Authors: Zheng Liange , Fernández Ana
Published: December 2023

Since nuclear energy is crucial in the decarbonization of the energy supply, one hurdle to remove is the handling of high-level radioactive waste (HLW). Disposal of HLW in a deep geological repository has long been deemed a viable permanent option. In the design of a deep geological repository, compacted bentonite is the most commonly proposed buffer material. Predicting the long-term chemical evolution in bentonite, which is important for the safety assessment of a repository, has been challenging because of the complex coupled processes. Models for large-scale tests and predictions based on such models have been some of the best practices for such purposes. An 18-year-long in situ test with two dismantling events provided a unique set of chemical data that allowed for studying chemical changes in bentonite. In this paper, we first developed coupled thermal, hydrological, mechanical, and chemical (THMC) models to interpret the geochemical data collected in the in situ test and then extended the THMC model to 200 years to make long-term prediction of the geochemical evolution of bentonite. The interpretive coupled THMC model shows that the geochemical profiles were strongly affected by THM processes such as evaporation/condensation, porosity change caused by swelling, permeability change, and the shape of concentration profiles for major cations were largely controlled by transport processes, but concentration levels were regulated by chemical reactions, and the profiles of some species such as pH, bicarbonate, and sulfate were dominated by these reactions. The long-term THMC model showed that heating prolongs the time that bentonite becomes fully saturated in the area close to the heater/canister; however, once the bentonite becomes fully saturated, high concentrations of ions in bentonite near the heater, which was observed in the field test, will disappear; illitization continues for 50 years but will not proceed further.
In Situ Sintering of CdSe/CdS Nanocrystals under Electron Beam Irradiation
Authors: Tang Luping , Zhang Chun , Liao Chen , Liu Yiwei , Cheng Yonghao
Published: December 2023

Colloidal semiconductor nanocrystals have attracted widespread attention due to their tremendous electrical and optical properties. Nanoparticles exhibit a strong tendency to aggregate and sinter in a short period of time during processing or use due to their large surface area-to-volume ratio, which may lead to significant changes in their required performance. Therefore, it is of great significance to conduct in-depth research on the sintering process and mechanism of nanoparticles to maintain their stability. Here, the sintering process of CdSe/CdS core/shell nanocrystals under continuous electron beam irradiation was studied using in situ transmission electron microscopy (TEM). In the early stages of sintering, CdSe/CdS nanocrystals approached each other at a distance of approximately 1–2 nm. As the exposure time to the electron beam increased, the movement of surface atoms on the nanocrystals led to contact between them. Subsequently, the atoms on the contact surfaces underwent rapid motion, resulting in the rapid formation of the neck between the particles. The neck formation between adjacent particles provides strong evidence of a sintering mechanism dominated by surface atom diffusion rather than Ostwald ripening. Further research in this area could lead to the development of improved methods to prevent sintering and enhance the stability of nanocrystals, ultimately contributing to the advancement of nanomaterial-based devices and materials with long-lasting performance.
Rational Design of TiO2@g-C3N4/CNT Composite Separator for High Performance Lithium-Sulfur Batteries to Promote the Redox Kinetics of Polysulfide
Authors: Dong Lingling , Jiang Wen , Pan Kefeng , Zhang Lipeng
Published: December 2023

Lithium–sulfur batteries (LSB) show excellent potential as future energy storage devices with high energy density, but their slow redox kinetics and the shuttle effect seriously hinder their commercial application. Herein, a 0D@2D composite was obtained by anchoring polar nano-TiO2 onto a 2D layered g-C3N4 surface in situ, and a functional separator was prepared using multi-walled carbon nanotubes as a conductive substrate. Due to their long-range conductivity, multi-walled carbon nanotubes make up for the low conductivity of TiO2@g-C3N4 to some extent. A lithium–sulfur battery prepared with a modified separator exhibited excellent long-term cycle performance, a good lithium ion diffusion rate, and rapid redox kinetics. The initial specific discharge capacity of the composite was 1316 mAh g−1 at 1 C, and a high specific discharge capacity of 569.9 mAh g−1 was maintained after 800 cycles (the capacity decay rate per cycle was only 0.07%). Even at the high current density of 5 C, a specific capacity of 784 mAh g−1 was achieved. After 60 cycles at 0.5 C, the modified separator retained the discharge capacity of 718 mAh g−1 under a sulfur load of 2.58 mg cm−2. In summary, the construction of a heterojunction significantly improved the overall cycle stability of the battery and the utilization rate of active substances. Therefore, this study provides a simple and effective strategy for further improving the overall performance and commercial application of lithium–sulfur batteries.
Nomophobia and Its Relationship with Social Anxiety and Procrastination in Nursing Students: An Observational Study
Authors: Tárrega-Piquer Irene , Valero-Chillerón María Jesús , González-Chordá Víctor Manuel , Llagostera-Reverter Irene , Cervera-Gasch Águeda , Andreu-Pejo Laura , Pérez-Cantó Víctor , Ortíz-Mallasén Víctor , Blasco-Palau Guillem , Mena-Tudela Desirée
Published: December 2023

Nomophobia is a phenomenon that describes the fear of not having one’s mobile phone accessible. This study aimed to evaluate the presence of nomophobia among nursing students as well as its relationship with procrastination and social anxiety. Methods: An observational, descriptive, cross-sectional study was conducted in a sample of 308 nursing students. Data were collected using the Nomophobia Questionnaire, Academic Procrastination Scale-Short Form, and Social Anxiety Questionnaire for Adults. Additionally, sociodemographic variables related to academic performance and smartphone use were collected. We performed a descriptive, bivariate, and multivariate analysis of the Nomophobia Questionnaire score. Results: 19.5% (n = 60) of the students presented with or were at high risk of nomophobic behaviour. Moreover, nomophobic behaviour was positively correlated with high levels of social anxiety (p < 0.001), longer daily smartphone usage time (p < 0.001), and a high frequency of smartphone checking in class (p < 0.001). The predictive variables for nomophobic behaviour included age, variables related to smartphone use, social anxiety levels, work, procrastination tendency, sex, and self-reported average grade. Conclusion: One out of five students in the sample studied presented with or were at high risk of nomophobic behaviour. Additionally, nomophobic behaviour was associated with social anxiety and variables related to smartphone use. This study was not registered.
Vaccine Hesitancy in Central Switzerland: Identifying and Characterizing Undervaccinated Children in a Pediatric Emergency Department
Authors: Ménétrey Anika , Landolt Markus A. , Buettcher Michael , Neuhaus Thomas J. , Simma Leopold
Published: December 2023

Vaccinations play an important role in the prevention of potentially fatal diseases. Vaccine hesitancy has become an important problem both in the public discourse and for public health. We aimed to identify and characterize this potentially unvaccinated or incompletely vaccinated group of children presenting to the pediatric emergency department (PED) of the tertiary children’s hospital in central Switzerland, a region that has anecdotally been claimed as a hotspot for vaccine hesitancy. All patients presenting to the PED (N = 20,247) between September 2018 and September 2019 were screened for their vaccination status and categorized as incomplete, unvaccinated, or fully vaccinated in a retrospective cohort study. Some 2.6% (n = 526) visits to the PED were not or incompletely vaccinated according to age, or their vaccination status was unknown. Most of the children in the cohort were not critically ill, and the minority had to be hospitalized. Undervaccinated patients were overrepresented in rural areas. Of all cohort visits, 18 (3.4%) patients received opportunistic vaccination in the PED. No cases of vaccine-preventable diseases were observed. In summary, incompletely vaccinated and unvaccinated status was less frequent than initially expected. The PED may play a role in increasing vaccination coverage by providing opportunistic vaccinations.
Simultaneous Prediction Method for Intestinal Absorption and Metabolism Using the Mini-Ussing Chamber System
Authors: Kondo Satoshi , Miyake Masateru
Published: December 2023

Many evaluation tools for predicting human absorption are well-known for using cultured cell lines such as Caco-2, MDCK, and so on. Since the combinatorial chemistry and high throughput screening system, pharmacological assay, and pharmaceutical profiling assay are mainstays of drug development, PAMPA has been used to evaluate human drug absorption. In addition, cultured cell lines from iPS cells have been attracting attention because they morphologically resemble human intestinal tissues. In this review, we used human intestinal tissues to estimate human intestinal absorption and metabolism. The Ussing chamber uses human intestinal tissues to directly assay a drug candidate’s permeability and determine the electrophysiological parameters such as potential differences (PD), short circuit current (Isc), and resistance (R). Thus, it is an attractive tool for elucidating human intestinal permeability and metabolism. We have presented a novel prediction method for intestinal absorption and metabolism by utilizing a mini-Ussing chamber using human intestinal tissues and animal intestinal tissues, based on the transport index (TI). The TI value was calculated by taking the change in drug concentrations on the apical side due to precipitation and the total amounts accumulated in the tissue (Tcorr) and transported to the basal side (Xcorr). The drug absorbability in rank order, as well as the fraction of dose absorbed (Fa) in humans, was predicted, and the intestinal metabolism of dogs and rats was also predicted, although it was not quantitative. However, the metabolites formation index (MFI) values, which are included in the TI values, can predict the evaluation of intestinal metabolism and absorption by using ketoconazole. Therefore, the mini-Ussing chamber, equipped with human and animal intestinal tissues, would be an ultimate method to predict intestinal absorption and metabolism simultaneously.
Association of Bitter Taste Receptors with Obesity and Diabetes and Their Role in Related Tissues
Authors: Kato Eisuke , Oshima Shota
Published: December 2023

Taste 2 receptors (T2Rs) are G-protein-coupled receptors responsible for sensing bitter tastes. Many studies have shown the expression of T2Rs in extraoral tissues and the unique role of T2Rs in each tissue. Single-nucleotide polymorphisms of T2Rs are associated with the risk of obesity and diabetes, and the organs/tissues associated with the development of these metabolic diseases, including the intestine, adipose, muscle, liver, and pancreas, are reported to express T2R genes. This result suggests that T2Rs in extraoral tissues contribute to the development of obesity and diabetes. In this narrative review, we summarize current knowledge of the associations of T2Rs with obesity and diabetes, provide an overview of extraoral tissues that are associated with the development of obesity and diabetes that express T2R genes, and summarize the current knowledge of T2Rs.
Written Remains: Materiality and the Religious Heritage Complex of the Jewish Portuguese Past
Authors: Isnart Cyril
Published: December 2023

Hebraic written stones represent the primary surviving physical testimony to the Jewish past in Portugal, apart from a Medieval synagogue in the city of Tomar. As it is true for other religious objects, medieval Hebraic epigraphic stones have become a heritage asset, opening the way to specific recognition of the Jewish materiality of Portugal. Long after the forced conversion of Portuguese Jews to Catholicism or their exodus, a few epigraphic testimonials were collected, maintained, and displayed. A group of 20th century Jewish and non-Jewish amateur archaeologists and historians assembled manuscripts, books and stones and attempted to establish a museum in the medieval synagogue of Tomar. They dedicated themselves to the study and preservation of this written religious legacy and proposed to focus on the letter as the principal material heritage to represent the Portuguese Jewish past. Drawing on the concept of religious heritage complex, this article describes how letters, as material remains, lead to the cultural renewal of a religious minority’s past. The study also sheds light on the cultural and religious consequences of this attention to letters on the heritage-making process itself. Through a combination of archival study, ethnographic fieldwork and comparison, the study sought to better understand the late destiny of the written remains of Judaism in Portugal.
Remote Sensing Analysis for Vegetation Assessment of a Large-Scale Constructed Wetland Treating Produced Water Polluted with Oil Hydrocarbons
Authors: Al-Jabri Khaled , Al-Mulla Yaseen , Melgani Farid , Stefanakis Alexandros
Published: December 2023

The identification and assessment of plant stress using wetland satellite images is a major task in remote sensing. In this study, one of the largest constructed wetlands (CWs) in the world, located in the Sultanate of Oman, was examined, assessed, and evaluated using remote sensor data from Sentinel-2. This CW system treats produced water generated during oil exploration activities in a desert environment; thus, CW vegetation is subjected to stress induced by oil hydrocarbons and water salinity. This study examined the plant stress and detected changes between the years of 2017 and 2019. Sentinel satellite images were evaluated for vegetation status extraction. The Normalized Difference Vegetation Index (NDVI), Modified Soil-Adjusted Vegetation Index (MSAVI), and Normalized Difference Salinity Index (NDSI) were used to evaluate the vegetation change. The results showed a comprehensive mapping identification of the plant stress and water flow parameter factors including oil in water contamination (OIW), dissolved oxygen (DO), water temperature (WT), and water conductivity (COND). Among the three indices, it was found that the NDVI showed a very good correlation with all parameters in both years with average R2 = 0.78, 0.67, 0.75, and 0.60 for OIW, DO, WT, and COND, respectively. The same trend was found for MSAVI but with R2 = 0.59, 0.48, 0.55, and 0.56 for OIW, DO, WT, and COND, respectively. This shows that the NDVI performed better than the MSAVI in evaluating the water flow parameters. On the other hand, the NDSI showed a strong correlation with one flow parameter, that is, water conductivity, especially at the outlet cells of the CW with R2 = 0.86 and 0.82 for winter time and summer time, respectively. The synchronization and correlation between the water flow parameters and remote sensing vegetation indices in this study lead to a new approach to large-scale landscape wetland monitoring that improves and helps predict any degradation or stress on vegetation growth. Furthermore, the results of this work can help decision makers potentially modify the wetland design and water flow path to improve future expansion phases. The mapping of such a critical and massive industrial CW should consider the use of high spatial resolution sensors where identifications and classifications are further improved. In summary, this research demonstrates that it is feasible to estimate vegetation stress within the constructed wetland using remote sensing techniques across extensive regions when an ample dataset comprising field data, satellite imagery, and supporting information is accessible.
Chronic Sufferers and Environmental Conditions
Authors: Vrouva Sotiria , Sopidou Varvara , Sifakis Emmanouil , Ntoulaveris Ilias , Papamarkos Georgios , Tse Gesthimani , Chanopoulos Konstantinos , Koumantakis George
Published: December 2023

Environmental conditions are associated with the onset of pain or the recurrence of symptoms of chronic sufferers either with musculoskeletal pathologies or neurological diseases. Recent research has indicated that physiotherapy also appears to be helpful in dealing with the symptoms of climate change. The purpose of this study was to investigate how temperature and precipitation are associated with referrals for physical therapy. All the data were collected retrospectively for three years, 2020–2022. A total of 2164 referrals were studied, 78% of which were female cases. Our results highlighted that (a) referrals with musculoskeletal problems are associated with the weather indicators of temperature and precipitation, (b) this relation was found to be stronger for females, and (c) there were slightly differentiated trends between them and those with neurological problems. These results suggest that low temperatures and high precipitation are strongly associated with increased referrals for chronic musculoskeletal pain and that females are more vulnerable to precipitation. Moreover, the increased number of referrals with chronic neurological problems was found to be associated with extreme temperatures. Considering these findings, rehabilitation centers and healthcare systems have the opportunity to immediately provide reliable and qualitative services, guided always by the safety and maximum relief of chronic sufferers.
Revisiting the Large n (Sample Size) Problem: How to Avert Spurious Significance Results
Authors: Spanos Aris
Published: December 2023

Although large data sets are generally viewed as advantageous for their ability to provide more precise and reliable evidence, it is often overlooked that these benefits are contingent upon certain conditions being met. The primary condition is the approximate validity (statistical adequacy) of the probabilistic assumptions comprising the statistical model Mθ(x) applied to the data. In the case of a statistically adequate Mθ(x) and a given significance level α, as n increases, the power of a test increases, and the p-value decreases due to the inherent trade-off between type I and type II error probabilities in frequentist testing. This trade-off raises concerns about the reliability of declaring ‘statistical significance’ based on conventional significance levels when n is exceptionally large. To address this issue, the author proposes that a principled approach, in the form of post-data severity (SEV) evaluation, be employed. The SEV evaluation represents a post-data error probability that converts unduly data-specific ‘accept/reject H0 results’ into evidence either supporting or contradicting inferential claims regarding the parameters of interest. This approach offers a more nuanced and robust perspective in navigating the challenges posed by the large n problem.
Maze Solving Mobile Robot Based on Image Processing and Graph Theory
Authors: Avila-Sánchez Luis A. , Sánchez-López Carlos , Ochoa-Montiel Rocío , Montalvo-Galicia Fredy , Sánchez-Gaspariano Luis A. , Hernández-Mejía Carlos , González-Hernández Hugo G.
Published: December 2023

Advances in the development of collision-free path planning algorithms are the main need not only to solve mazes with robotic systems, but also for their use in modern product transportation or green logistics systems and planning merchandise deliveries inside or outside a factory. This challenge increases as the complexity of the task in its structure also increases. This paper deals with the development of a novel methodology for solving mazes with a mobile robot, using image processing techniques and graph theory. The novelty is that the mobile robot can find the shortest path from a start-point to the end-point into irregular mazes with abundant irregular obstacles, a situation that is not far from reality. Maze information is acquired from an image and depending on the size of the mobile robot, a grid of nodes with the same dimensions of the maze is built. Another contribution of this paper is that the size of the maze can be scaled from 1 m × 1 m to 66 m × 66 m, maintaining the essence of the proposed collision-free path planning methodology. Afterwards, graph theory is used to find the shortest path within the grid of reduced nodes due to the elimination of those nodes absorbed by the irregular obstacles. To avoid the mobile robot to travel through those nodes very close to obstacles and borders, resulting in a collision, each image of the obstacle and border is dilated taking into account the size of the mobile robot. The methodology was validated with two case studies with a mobile robot in different mazes. We emphasize that the maze solution is found in a single computational step, from the maze image as input until the generation of the Path vector. Experimental results show the usefulness of the proposed methodology, which can be used in applications such as intelligent traffic control, military, agriculture and so on.
Assessing the Efficiency of a Drinking Water Treatment Plant Using Statistical Methods and Quality Indices
Authors: Bărbulescu Alina , Barbeș Lucica
Published: December 2023

This study presents the efficiency of a drinking water treatment plant from Constanța, Romania. Individual and aggregated indices are proposed and built using nine water parameters for this aim. The analysis of individual indices permits the detection of the period of malfunctioning of the water treatment plant with respect to various parameters at various sampling points. In contrast, the cumulated indices indicate the overall performance of the treatment plant during the study period, considering all water parameters. It was shown that the outliers significantly impact the values of some indices. Comparisons between the simple average and weighted average indices (built taking into account the importance of each parameter) better reflect the impact on the water quality of some chemical elements that might harm people’s health when improperly removed.
Assessment of Community Awareness and Screening of Chagas Disease in the Latin American Community of Greater New Orleans
Authors: Herrera Claudia , Bernabé Kerlly J. , Dumonteil Eric , DeCuir James , Thompson Julie M. , Avendano Mariana , Tu Weihong , Leonhardt Maxwell M. , Northland Bianka A. , Frederick Jynx , Prieto Bryn , Paternina-Caicedo Angel , Ortega Emma , Fonseca Maria , Hincapie Marcela , Echeverri Margarita
Published: December 2023

Chagas disease is a public health problem in the Americas, from the southern United States (USA) to Argentina. In the USA, less than 1% of domestic cases have been identified and less than 0.3% of total cases have received treatment. Little is known about affected immigrant Latin American communities. A prospective study was conducted to assess knowledge about Chagas disease among the Latin American community living in the Greater New Orleans area. Participants answered a baseline questionnaire, viewed a short educational video presentation, completed a post-presentation questionnaire, and were screened with an FDA-approved blood rapid diagnostic test (RDT). A total of 154 participants from 18 Latin American countries (n = 138) and the USA (n = 16) were enrolled and screened for Trypanosoma cruzi infection. At baseline, 57% of the participants knew that Chagas disease is transmitted through an insect vector, and 26% recognized images of the vector. Following the administration of an educational intervention, the participants’ knowledge regarding vector transmission increased to 91% and 35% of participants were able to successfully identify images of the vector. Five participants screened positive for T. cruzi infection, indicating a 3.24% [95%CI: 1.1–7.5%] prevalence of Trypanosoma cruzi infection within the Latin American community of the New Orleans area. Results highlight the urgent need for improving access to education and diagnostics of Chagas disease.
The Apparent Tidal Decay of WASP-4 b Can Be Explained by the Rømer Effect
Authors: Harre Jan-Vincent , Smith Alexis M. S.
Published: December 2023

Tidal orbital decay plays a vital role in the evolution of hot Jupiter systems. As of now, this has only been observationally confirmed for the WASP-12 system. There are a few other candidates, including WASP-4 b, but no conclusive result could be obtained for these systems as of yet. In this study, we present an analysis of new TESS data of WASP-4 b together with archival data, taking the light–time effect (LTE) induced by the second planetary companion into account as well. We make use of three different Markov chain Monte Carlo models: a circular orbit with a constant orbital period, a circular orbit with a decaying orbit, and an elliptical orbit with apsidal precession. This analysis is repeated for four cases. The first case features no LTE correction, with the remaining three cases featuring three different timing correction approaches because of the large uncertainties of the ephemeris of planet c. Comparison of these models yields no conclusive answer to the cause of WASP-4 b’s apparent transit timing variations. A broad range of values of the orbital decay and apsidal precession parameters are possible, depending on the LTE correction. However, the LTE caused by planet c can explain on its own—in full—the observed transit timing variations of planet b, with no orbital decay or apsidal precession being required at all. This work highlights the importance of continued photometric and spectroscopic monitoring of hot Jupiters.
Intensified Influenza Virus Production in Suspension HEK293SF Cell Cultures Operated in Fed-Batch or Perfusion with Continuous Harvest
Authors: Silva Cristina A. T. , Kamen Amine A. , Henry Olivier
Published: December 2023

Major efforts in the intensification of cell culture-based viral vaccine manufacturing focus on the development of high-cell-density (HCD) processes, often operated in perfusion. While perfusion operations allow for higher viable cell densities and volumetric productivities, the high perfusion rates (PR) normally adopted—typically between 2 and 4 vessel volumes per day (VVD)—dramatically increase media consumption, resulting in a higher burden on the cell retention device and raising challenges for the handling and disposal of high volumes of media. In this study, we explore high inoculum fed-batch (HIFB) and low-PR perfusion operations to intensify a cell culture-based process for influenza virus production while minimizing media consumption. To reduce product retention time in the bioreactor, produced viral particles were continuously harvested using a tangential flow depth filtration (TFDF) system as a cell retention device and harvest unit. The feeding strategies developed—a hybrid fed-batch with continuous harvest and a low-PR perfusion—allowed for infections in the range of 8–10 × 106 cells/mL while maintaining cell-specific productivity comparable to the batch control, resulting in a global increase in the process productivity. Overall, our work demonstrates that feeding strategies that minimize media consumption are suitable for large-scale influenza vaccine production.
Characteristics of the modern nut market
Authors:   OOO “Semushka”, Moscow, Livinskiy A.A. , Krasavin A.S. ,   FSBI ROSBIOTECH, Pavlovskiy A.S. ,   FSBI ROSBIOTECH, Lapin A.V. ,   FSBI ROSBIOTECH
Published: December 2023

Despite seasonal fl uctuations depending on annual climatic conditions, the nut market is showing steady growth. The increase in nut production is explained by the rise in their consumption as a raw material for confectionery products, as well as for direct consumption as an alternative source of basic and physiologically active substances. In total, 5,367,530 tons of nuts were produced in the 2022–2023 marketing year (excluding peanuts). Almonds lead the world production. It is followed by walnuts, cashews, pistachios, and hazelnuts. Pine nuts are the only nut produced in the Russian Federation on an industrial scale. According to Russian data, in the 2022/23 season, the country produced about 35 thousand tons of pine nuts in shell, which is half of the world production of this type. Global production of inshell peanuts annually is about 50 million tons.
Current problems of packaging in foreign economic activity
Authors:   Plekhanov Russian University of Economics, Chalykh T.I. , Raikova E.Yu. ,   Plekhanov Russian University of Economics
Published: December 2023

Until recently, cardboard and paper packaging for food liquids dominated the Russian consumer market, but companies bought fabricated parts from European manufacturers. The issue of interchangeability of packaging for food liquids and the advantages and disadvantages of packaging from the point of view of environmental properties are discussed.
MENINGKATKAN PERLINDUNGAN INVESTOR DALAM USAHA HULU MINYAK DAN GAS BUMI DALAM KONTEKS INDONESIA
Authors: - Mardianto , Pieris John , Widiarty Wiwik S.
Published: December 2023

The primary objective of this research is to assess the degree of legal assurance and protection accessible to investors involved in upstream oil and gas operations within the Republic of Indonesia's jurisdiction. The goal is to offer valuable insights to relevant decision-makers and stakeholders,  aiming to enhance the legal assurance and protection afforded to investors in this sector, thereby contributing to the nation's overall stability. The research methodology employed in this study is normative and qualitative juridical legal research, incorporating statutory and conceptual approaches. The research findings highlight the necessity for legislative enhancements, particularly implementing  the Job Creation Law. This legislation will  enhance the regulatory framework, ensuring legal assurance under Article 169, Section A of the Minerba Law. This provision stresses that holders of Mining Business Permits (KK) should not encounter premature contract terminations and advocates for rigorous law enforcement in cases of violations. Furthermore, the study acknowledges the significance of Law No. 25 of 2007, which safeguards legal and business assurance for investors, notably through the Omnibus Law.
ANALISIS UPAYA DAN PERAN PERLINDUNGAN HUKUM TERHADAP KASUS PERETASAN DATA BANK SYARIAH INDONESIA
Authors: Keliat Venia Utami , Siregar Andini Pratiwi , Zulkifli Suhaila , Purba Iin
Published: December 2023

The development of information and communication technology has had a significant impact on various sectors of life, including the banking sector. The legal system has made essential safeguards to protect bank and customer data security. The latest information regarding developments in the Indonesian Kapital data leak case must be sought through trusted news sources or contacting authorities such as the OJK or Bank Indonesia to obtain accurate and up-to-date information. The Consumer Protection Law seeks to protect bank customers by limiting standard clauses that cannot be avoided in today's banking business world. The method in this research uses normative legal research.
Issues that occur in the banking world relate to the legal position of banking in cases of leakage of Indonesian Sharia Bank customer data and banking legal protection efforts that have been carried out by the legal system to protect the security of bank data and customer data. There are two factors that cause leaks of customer personal data, namely internal and external factors. Cases of customer data leakage are serious violations of privacy and information security. Banks, including Islamic banks, have a big responsibility in maintaining the confidentiality of customer data and protecting their personal information. If a data leak occurs, the bank could face legal and regulatory consequences, and could potentially harm their reputation. The method in this research uses normative legal research.
EDUCAÇÃO DA INFÂNCIA EM ALAGOAS NAS FÁBRICAS DE TECIDO ENTRE 1930 E 1970
Authors: Aderne Aline da Silva Ferreira , Haddad Lenira
Published: December 2023

Este artigo apresenta os principais modos de educação da infância de 0 a 6 anos de idade em fábricas de tecido que se estabeleceram em Alagoas entre meados do século 19 e início do século 20. A existência de creches e jardins de infância nas indústrias têxteis é mencionada nos relatos orais, mas não se tem acesso a documentos, tampouco há informações sistematizadas. O percurso metodológico, pautado na história oral, envolveu a busca de informantes por meio da técnica de Snowball e a realização de entrevistas a figuras que compõem essa história, além de pesquisa documental. Expõe um breve panorama universo fabril-têxtil alagoano composto por 13 fábricas de tecido e apresenta a história da educação da infância em quatro dessas fábricas situadas em três municípios alagoanos: Delmiro Gouveia, Maceió e Rio Largo, abrangendo o período de 1930 a 1970. Fica evidente que essas fábricas ofertaram a educação de crianças de 0 a 6 anos por meio de creches e jardins de infância muito antes de a educação infantil ser uma política municipal regulamentada.
Targeting Senescent Cells as Therapy for CKD
Authors: Mylonas Katie J. , Ferenbach David A.
Published: December 2023

Senescent cells accumulate in the kidney with aging, after acute and chronic injuries, and are present in increased numbers in deteriorating kidney transplants. Senescent cells have undergone permanent cell cycle arrest and release many proinflammatory cytokines/chemokines and profibrotic factors: the senescence-associated secretory phenotype. Recent work from several groups including our own has shown that senescent cells play a causative role in progression of kidney disease. Experimental evidence also indicates that targeting senescent cells has potential to alter the renal regenerative response, reducing progressive fibrosis and improving functional recovery after injury. Research and clinical interest is focused on understanding how accumulating chronic senescent cells link acute injury to progressive fibrosis, dysfunction, and mortality in human CKD. In this review, we outline current protocols for the identification of how senescent cells are identified in vitro and in vivo. We discuss the proposed mechanisms of actions of first-generation senolytic and senomorphic agents, such as ABT-263 (navitoclax) which targets the BCL2 family of survival factors, and senomorphic agents such as metformin which targets aspects of the senescence-associated secretory phenotype. We also review that emerging technologies, such as nanocarriers, are now being developed to have safer delivery systems for senolytics, greater specificity, fewer off-target effects, and less toxicity. Other methods of senescent cell elimination being developed target various immune evasion tactics displayed by these cells. By understanding the role of senescence in kidney homeostasis and disease, developing new, targeted compounds and the tools to allow their efficacy to be charted noninvasively, it should become possible for senolytic treatments to move from the bench to bedside.
An ecological study of the incidence and mortality rates of pancreatic cancer in 2020: exploring gender disparities worldwide
Authors: Moradi Nahid , Ghorbani Doshantapeh Anna , Sangi Siavash , Aligholizadeh Maryam , Asadian Ali , Abdolmohammadi Golmis , Gharebakhshi Farshad , Abdolmohammadi Golara , Molaee Hanieh
Published: December 2023

Introduction: Pancreatic cancer is a highly mortal disease that used to be rare but its incidence rate has increased in the last few decades. Despite declining overall cancer incidence and mortality rates in developed countries, pancreatic cancer tends to increase in both incidence and mortality. Previous studies showed a male predominance in pancreatic cancer in patients older than 35. However, considering the sudden rise in incidence in young females, a new survey is crucial to address the current pattern of pancreatic cancer distribution between males and females. Hormonal factors may play a role in the pathogenesis of pancreatic cancer. Objectives: This study aimed to evaluate the role of gender differences in mortality and incidence of pancreatic cancer in an ecological study based on data extracted from the GLOBOCAN project in 2020. Patients and Methods: An ecological study was carried out to assess gender disparity in pancreatic cancer incidence and mortality rates. The data used in the study were obtained from the Global Cancer (GLOBOCAN) project of the World Health Organization (WHO) in 2020 (https://gco.iarc.fr/). Results: The pancreatic cancer mortality rate worldwide (2020) was estimated at 466,003 cases, encompassing 246,840 cases (52.96%) among males and 219,163 cases (47.04%) among females. The study found that although there were differences in the mean pancreatic cancer incidence and mortality rates between males and females when measured by indicators such as number, ASR, and crude rate, these differences were not statistically significant. Conclusion: In conclusion, the pancreatic cancer incidence and mortality rate is increasing worldwide. In spite of the fact that men die from pancreatic cancer at a higher rate than women, there is no statistically significant difference between the two. Registration: The study protocol was registered on the Research Registry website with the unique identification number (UIN) researchregistry9598.
Comparing the effectiveness of hyperimmune plasma and plasmapheresis in COVID-19 patients
Authors: Ahmadi Neda Sadat , Samimagham Hamid Reza , Hassaniazad Mehdi , Khajavi-Mayvan Fatemeh , Sheybani-Arani MohammadHosein , Salimi Asl Ali , Kazemi Jahromi Mitra
Published: December 2023

Introduction: In December 2019, the first clinical signs of patients infected with SARS CoV 2 surfaced, then the fatality rate rose daily with no available definitive therapy. Objectives: Considering the necessity for more research into plasma therapy, the urgency of treating patients with a severe disease, and the lack of comparable studies, we compared the effectiveness of hyperimmune plasma and plasmapheresis in COVID-19 patients. Patients and Methods: In this quasi-experimental study, 38 patients with severe COVID-19 were enrolled in two groups of 19 individuals treated with plasmapheresis and hyperimmune plasma after matching for severity. The researcher documented the patient’s information on a checklist submitted for statistical analysis using the SPSS software. Results: Patients comprised 60.53% of men and 39.5% of women. In this study, 60.53% of patients had underlying conditions, including hypertension and diabetes. The mean length of hospitalization for patients in the hyperimmune plasma group was considerably shorter than those in the plasmapheresis group (P<0.05). Conclusion: The average hospitalization time for patients who received hyperimmune plasma was considerably shorter than the plasmapheresis group. As a result, patients are encouraged to utilize this type of plasma at the earliest stages of the condition.
Assessing global kidney cancer incidence and mortality rates according to population category by income levels in 2020: An ecological study
Authors: Alivand Soleyman , Fattahi Farinaz , Zarei Zahra , Hosseinifard Mehdi , Nouralishahi Atieh , Karimi Aliabadi Hakimeh , Soltani Nejad Simin , Alivand Noorbakhsh , Molaee Hanieh , Ghorbani Doshantapeh Anna
Published: December 2023

Introduction: Population categories based on income levels are frequently utilized to compare cancer rates across various countries. It is a valuable tool for assessing global health and helps to classify cancers and measure the incidence and mortality of different types of cancer. Objectives: This study aimed to evaluate global kidney cancer incidence and mortality rates in 2020 according to population category by income levels, using an ecological study design. Methods and Materials: This ecological study examines the correlation between the incidence and mortality of kidney cancer in 2020, reported by the GLOBOCAN project, since the population category by income levels was reported by the World Bank report. The linear regression method was conducted to assess this correlation. Results: Results demonstrated that the global incidence and mortality rate of kidney cancer in 2020 was estimated at 431288 and 179368 cases, respectively. The incidence and mortality rate of kidney cancer were higher in high-income countries, and both rates tend to be higher in more developed regions. However, there was no statistically significant correlation between the population category by income levels and kidney cancer incidence and mortality based on both crude rate (CR) and age-standardized rate (ASR) indicators (P>0.05). Conclusion: We conclude that incidence and mortality rates of kidney cancer are not associated with population category by income level.
PENGARUH DEWAN DIREKSI, DEWAN KOMISARIS DAN KOMITE AUDIT TERHADAP KINERJA KEUANGAN (STUDI EMPIRIS PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2018-2021)
Authors: Rosdiana
Published: December 2023

This study aims to investigate the effects of of the Board of Directors, Board of Commissioners andAudit Committee on the Financial Performance of Banking Companies listed on the IndonesiaStock Exchange (IDX) for the 2018-2022 period. The research sample consists of 28 commercialbanks by selecting each company with financial statements that include the number of the Boardof Directors, Board of Commissioners and Audit Committee. The results of the study show that theBoard of Directors has a significant negative effect on financial performance. While the Board ofCommissioners and the Audit Committee have no effect on financial performance
Pentingnya Etika Islam Pada Profesi Akuntan
Authors: Ivahzada Marella Edgina
Published: December 2023

This study explores the extent to which accountants are involved in financial reporting scandals causedby the ethical judgment of certain accountants and a number of academics recommend that theeducation system be held accountable. The paper argues that in applying accounting ethics, especiallyIslam, accounting education must focus on ethical codes and religious values.
URGENSI AUDITOR SYARIAH PADA INDUSTRI KEUANGAN SYARIAH
Authors: Ivahzada Marella Edgina, SE., M.ESy.
Published: December 2023

The Islamic finance industry has gained international recognition as part of the global financial system. The Islamic finance industry has developed rapidly over the last few decades. To be able to maintain the existence and trust of users and the general public, the Islamic finance industry must comply with sharia regulations to ensure that business activities and other corporate activities comply with sharia principles. Therefore, sharia auditors play an important role in maintaining transparency and public trust in the integrity of the Islamic finance industry as an Islamic institution. Sharia audit has a major interest in the Islamic finance industry. With the existence of a sharia audit in the industry, it will prove that the industry is in the right industry in accordance with Islamic teachings
Pengaruh Motivasi dan Pelatihan terhadap Kinerja Karyawan PT Bank Central Asia, Tbk KCU Matraman Jakarta
Authors: Simamora Agus MD Simamora , Arry Dwi Syahputra
Published: December 2023

The purpose to determine the effect of motivation and training on employee performance PT. Bank Central Asia, Tbk KCU Matraman Jakarta. This research is included in the category of causal associative research using a quantitative approach. The research population amounted to 68 people, the sampling technique used a saturated sample, all members of the population were used as samples totaling 68 employees of PT. Bank Central Asia, Tbk KCU Matraman Jakarta. The research method uses partially and simultaneous linear regression analysis. The results of the study indicate that in partially or simultaneous ways, motivation and training have a positive and significant effect on the performance of employees of PT. Bank Central Asia, Tbk KCU Matraman Jakarta
PERBANDINGAN KINERJA SAHAM SEBELUM DAN SELAMA PANDEMI COVID-19
Authors: Garnia Erna , Rahayu Rani , Utari Rena Nur , Febriani Dini , Putri Hasna Qurratu-ain
Published: December 2023

Masuknya pandemi covid-19 di Indonesia mengakibatkan ketidakstabilan pada pergerakan harga saham di Bursa Efek Indonesia. Kelompok saham yang paling terdampak pandemi covid-19 diantaranya, LQ45, Saham Syariah, perbankan, dan Manufaktur. Ketidakstabilan tersebut mengakibatkan ketidakpastian return bagi para investor. Tujuan penelitian ini adalah untuk mengetahui adakah pengaruh risiko pasar terhadap return saham pada beberapa kelompok saham yang terbagi menjadi return tinggi dengan return rendah sebelum dan selama pandemi Covid-19. Metode analisis yang digunakan yaitu Two Pass Regression dengan pendekatan Capital Asset Pricing Model. Penelitian ini menggunakan data harian dari 12 Maret 2019 sampai dengan 1 Maret 2021. Hasil penelitian sebelum pandemi covid-19 pada kelompok LQ45, Saham Syariah, Perbankan dengan return tinggi maupun rendah menunjukkan bahwa risiko pasar tidak berpengaruh terhadap return saham sementara untuk manufaktur berpengaruh signifikan. Selama pandemic covid-19 pada kelompok LQ45, Saham Syariah, Perbankan, dan Manufaktur dengan return tinggi maupun return rendah menunjukkan risiko pasar berpengaruh signifikan terhadap return saham.
Soft Skills Mahasiswa Vokasi Akuntansi Dalam Penerapan Project-Based Learning
Authors: Riadi Sugeng , Zelmiyanti Riri
Published: December 2023

Tujuan penelitian ini adalah untuk mengetahui penilaian soft skills mahasiswa vokasi akuntansi dalam penerapan project-based learning. Penelitian ini merupakan applied research, dengan studi kasus pada mahasiswa D4 Akuntansi Manajerial Politeknik Negeri Batam yang sedang melakukan project-based learning. Pengumpulan data dilakukan secara alami (natural observation), dimana subjek penelitian tidak mengetahuinya. Hasil penelitian menunjukkan bahwa kemampuan attitude, problem solving, komunikasi, time management, leadership, organization skills, kerjasama dan etika sangat baik dan meningkat dalam penerapan project-based learning. Namun, dari sisi disiplin mahasiswa belum cukup baik
Amanda Arias: Una maestra que no quiso ser paradigma de nada (Santa Fe, primera mitad del siglo XX)
Authors: Pellegrini Malpiedi Micaela
Published: December 2023

Desde un enfoque que pone en diálogo a la historia sociocultural de la educación y la historia de/con mujeres en perspectiva de género, el siguiente artículo funda una serie de líneas de análisis alrededor de la trayectoria docente de la argentina Amanda Arias (1930-1955) y los intercambios, enfrentamientos y tretas de la misma, con agentes del sistema educativo y parte de la elite de su localidad, Rafaela.
En específico, este artículo sostiene que, al mirar microscópicamente las trayectorias de diferentes mujeres que habitaron las escuelas, es posible tender puentes para interpretar situaciones experienciales que ponen en evidencia problemáticas del sistema educativo argentino más generales, como por ejemplo, las lógicas patriarcales de los actores sociales que lo ocuparon, las implicancias de la sociedad civil en el sostenimiento de las instituciones educativas, o el ejercicio de la burocracia escolar, entre otras.