bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of self-regulation in the field of arbitration management
Authors:   Sergey A. Gorelkin St. Petersburg University of Management and Economics Technologies, Gorelkin Sergey A.
Published: September 2024

Рассматриваются и обобщаются точки зрения ученых по различным аспектам деятельности саморегулируемых организаций в разных сферах. Подчеркивается особая значимость точных и надежных механизмов самоорганизации в сфере антикризисного управления, поскольку это сказывается на эффективности российской экономики (в случае восстановления платежеспособности предприятиядолжника) и уровне жизни населения (квалифицированное внешнее управление может способствовать сохранению рабочих мест). Выявлены основные проблемы в деятельности саморегулируемых организаций арбитражных управляющих, многие из которых связаны с низкой компетентностью арбитражных управляющих. Предложено повысить требования к уровню профессионализма арбитражных управляющих, регулярно проводить их рейтинговую оценку на основе показателя «удельный вес успешно реализованных процедур финансового оздоровления в общем числе дел о банкротстве». Это побудит руководителей таких организаций более требовательно подходить к решению вопросов о членстве, предметно и детально осуществлять контроль, обеспечивать повышение квалификации своих членов, что будет способствовать повышению качества услуг арбитражных управляющих. При обосновании предлагаемых мер использовался опыт зарубежных стран.
Features of the employer's labor legal personality
Authors:   Amina G. Magomedova Dagestan State University, Magomedova Amina G.
Published: September 2024

В статье рассматриваются вопросы трудовой правосубъектности работодателя - юридического и физического лица, которые обладают специфическим правовым статусом, отличающимся от традиционного по ряду существенных признаков. Особое внимание уделено вопросам регулирования трудовых отношений в религиозной организации, а также применения дистанционного труда. Выделены особенности заключения и расторжения трудового договора, организации трудового процесса и установления режима труда у таких работодателей. В качестве примеров реализации отдельных положений законодательства приведены примеры из правоприменительной практики.
The importance of the operational service of the penal enforcement system in the process of correcting persons held in places of deprivation of liberty
Authors:   Kirill V. Odinokov Academy of Law and Management of the Federal Penitentiary Service, Odinokov Kirill V.
Published: September 2024

В статье рассмотрен нетрадиционный подход к деятельности оперативной службы пенитенциарной системы, отражающий алгоритм её участия в исправлении лиц, содержащихся в местах лишения свободы. Намечены конкретные способы использования оперативных данных не только для реализации задач оперативно-розыскной деятельности, указанных в соответствующих нормативно-правовых актах по данному направлению, но и для применения их, в качестве инструмента, способного стабилизировать абсолютно любое направление служебной деятельности учреждения. Предложен путь по созданию центрального планирующего органа, который должен сформировать систему, включающую порядок действий по специфическому использованию определенных средств, находящихся в арсенале оперативного отдела, для решения задач, направленных на исправление лиц, находящихся в местах лишения свободы. Приведены конкретные примеры из практической деятельности, подтверждающие необходимость создания нового планомерного подхода к процессу исправления осужденных с помощью сил и средств оперативной службы уголовно-исполнительной. Конечной целью статьи является попытка внесения изменений в действующую законодательную базу, расширить деятельность оперативной службы УИС, для формирования системы, имеющей своей главной задачей создание и поддержание единого центра, назначением которого будет регулирование исправительного процесса, в отношении лиц, отбывающих уголовное наказание в виде лишения свободы.
Ethnopolitical Federalism in the Republics of the Northern Caucasus at the end of the twentieth century
Authors:   Magomednabi M. Aibatov Dagestan State University, Aibatov Magomednabi M.
Published: September 2024

В статье рскрываются основные причины государственно-политического кризиса в Северо-Кавказском регионе в 90-х годах ХХ в., анализруются программные документы, цели и задачи национальных движений, возникших в регионе в этот период, говорится о зависимости развития этнополитического федерализма от уровня полиэтничности в республиках Северного Кавказа. Отмечается, что в Северо-Кавказском регионе, как и в других регионах страны, не было эффективной национальной и федеративной политики, хотя в постсоветский период федеральный центр неоднократно предпринимал попытки обеспечения этнополитической стабильность в стране, особенно в национальных республиках. Подчеркивается, что в обострении государственно-политической и межнациональной обстановки в регионе важную роль сыграли различные факторы, проявившиеся в требованиях повышения политико-правового статуса отдельных этнических групп, вплоть до создания национальной государственности. Федеральные органы власти оказались слишком инертными для оперативного разрешения возникающих в стране межнациональных конфликтов, затрагивающих основы федеративного государственного устройства Российской Федерации.
The place of artificial intelligence in the legal system of Russia
Authors:   Tatyana V. Vorotilina Plekhanov Russian University of Economics, Financial University under the Government of the Russian Federation, Vorotilina Tatyana V. , Korotchenko Alina V. ,   Alina V. Korotchenko Financial University under the Government of the Russian Federation
Published: September 2024

В статье авторы исследуют нормативные правовые акты, регулирующие деятельность искусственного интеллекта, а также доктринальные труды и правоприменительную практику использования ИИ. Анализируется правовой статус искусственного интеллекта и проблемы установления юридической ответственности разработчикам ИИ за совершение правонарушений. Обозначаются проблемы развития искусственного интеллекта в целом и, в частности, в правовой сфере. Рассматривается опыт использования ИИ-технологий в судебной системе Российской Федерации и других стран. Анализируется дефиниция «искусственный интеллект» и основные выделяемые в науке виды. Моделируются ситуации использования искусственного интеллекта при решении различных правовых задач и для помощи в работе юристам. Обращено внимание на имеющиеся в действующем законодательстве пробелы, регулирующие создание, разработку и эксплуатацию ИИ. Делается основной вывод о создании единого нормативного правового акта, устранении проблемных аспектов и о вариантах использования ИИ в судебной системе
Digitalization of the social sphere in the Russian Federation: general theoretical aspects
Authors:   Olga A. Plotskaya Plekhanov Russian University of Economics, Institute of Management Technologies of Federal State ", Plotskaya Olga A. ,   MIREARussian Technological University", Plockiy Bogdan A. ,   Bogdan A. Plockiy Moscow Aviation Institute (national research university), Babaev Rafael G. ,   Rafael G. Babaev Institute of Management Technologies of Federal State "MIREA-Russian Technological University"
Published: September 2024

Авторы статьи исследуют концепцию, основные понятия и ряд особенностей осуществления цифровизации социальной сферы в Российской Федерации. Стремительно развивающийся научно-технический прогресс спровоцировал появление множества инновационных терминов, таких как: «цифровая экономика», «цифровая трансформация», «цифровизация», «оцифровка» и др. Существующие научные изыскания по-разному трактуют эти понятия и неоднозначно их определяют. Правоприменительная практика показывает, что российский законодатель активно принимает нормативно-правовую базу, регулирующую применение цифровых технологий в социальной сфере, способствующую внедрению индивидуального (персонифицированного) учета, в электронном виде, что позволяет автоматически считывать и обрабатывать информацию. Процесс цифровизации социальной сферы в Российской Федерации и применение цифровых технологий прочно вошли в современную повседневную жизнь. Российское государство, применяя их, является конкурентоспособным, ставя перед собой задачу продвижения цифры, предоставляя каждому человеку возможность выбора в реализации своих прав в «цифровом пространстве». Такой положительный опыт в социальной сфере в России уже есть, включая предоставление помощи при применении процедуры упрощенного порядка получения выплат на детей; выплаты дополнительных пособий женщинам, которые стали на учет в медицинской организации на ранних сроках беременности; малоимущим гражданам, которые имеют несовершеннолетних детей в возрасте от 8 до 17 лет; введение электронных трудовых книжек.
On the issue of the conceptual relationship between the norm s of international and national law in the theory of public international law
Authors:   Madina N. Alieva Dagestan State University, Alieva Madina N.
Published: September 2024

В статье затрагивается проблема соотношения международного и внутригосударственного права, связанная с отсутствием единого подхода к определению соотношения норм указанных правопорядков. Рассматриваются основные теории взаимодействия международного и национального права. В основе одной из них, монистической, лежит представление о международном и внутригосударственном праве как о единой правовой системе, имеющей один предмет правового регулирования. Приводятся мнения ученых, поддерживающих идею примата внутригосударственного права над между-народным и наоборот. Анализируются международные документы, в которых идея примата международного права получила закрепление, в частности, нормы Устава ООН, Венской конвенции о праве международных договоров 1969 г., проекта статей об ответственности государств за международно-противоправные деяния 2001 г. Особое внимание уделяется анализу ряда конституций европейских гос-ударств по вопросу приоритета международного права над национальным. Автором исследуется концепция дуализма международного и национального права, строящаяся на идее самостоятельности и независимости международного и национального права, приводится критическое мнение отечественных ученых относительно состоятельности указанной теории, а также примеры закрепления дуалистических взглядов в науке международного публичного права.
Assessing Digital Phenotyping for App Recommendations and Sustained Engagement: Cohort Study
Authors: Dwyer Bridget , Flathers Matthew , Burns James , Mikkelson Jane , Perlmutter Elana , Chen Kelly , Ram Nanik , Torous John
Published: September 2024

Background

Low engagement with mental health apps continues to limit their impact. New approaches to help match patients to the right app may increase engagement by ensuring the app they are using is best suited to their mental health needs.

Objective

This study aims to pilot how digital phenotyping, using data from smartphone sensors to infer symptom, behavioral, and functional outcomes, could be used to match people to mental health apps and potentially increase engagement

Methods

After 1 week of collecting digital phenotyping data with the mindLAMP app (Beth Israel Deaconess Medical Center), participants were randomly assigned to the digital phenotyping arm, receiving feedback and recommendations based on those data to select 1 of 4 predetermined mental health apps (related to mood, anxiety, sleep, and fitness), or the control arm, selecting the same apps but without any feedback or recommendations. All participants used their selected app for 4 weeks with numerous metrics of engagement recorded, including objective screentime measures, self-reported engagement measures, and Digital Working Alliance Inventory scores.

Results

A total of 82 participants enrolled in the study; 17 (21%) dropped out of the digital phenotyping arm and 18 (22%) dropped out from the control arm. Across both groups, few participants chose or were recommended the insomnia or fitness app. The majority (39/47, 83%) used a depression or anxiety app. Engagement as measured by objective screen time and Digital Working Alliance Inventory scores were higher in the digital phenotyping arm. There was no correlation between self-reported and objective metrics of app use. Qualitative results highlighted the importance of habit formation in sustained app use.

Conclusions

The results suggest that digital phenotyping app recommendation is feasible and may increase engagement. This approach is generalizable to other apps beyond the 4 apps selected for use in this pilot, and practical for real-world use given that the study was conducted without any compensation or external incentives that may have biased results. Advances in digital phenotyping will likely make this method of app recommendation more personalized and thus of even greater interest.
Utilizing the VISIA Camera for Analyzing 5-Fluorouracil Treatment Efficacy for Actinic Keratosis (Preprint)
Authors: Woolhiser Emily , Kirk Jessica , Baum Bertha , Dellavalle Robert
Published: September 2024

UNSTRUCTURED

The VISIA camera is a novel device that captures images of the skin using a rotating camera with both UV and polarized light to assess the condition of the skin by imaging the surface and beneath it. It provides patients with an easy-to-understand analysis helping them understand their skin’s problem areas to target further treatment. Actinic Keratoses (AKs) are precancerous lesions that are diagnosed by use of the naked eye and the dermatoscope. We believe it would be beneficial to use the VISIA camera for AK patients to get an indepth look at the effects of sun exposure on their skin, providing motivation to undergo field treatment of AKs using 5-Fluorouracil (5-FU) for patients with hesitancy. We are conducting an observational study with results reported here on a male patient diagnosed with diffuse AKs who was prescribed and had consented to go through 5-FU treatment on the scalp. An initial photo was taken on the VISIA prior to treatment, 5-FU was applied twice daily to the scalp for 4 weeks and a follow up photo was obtained 1 week and 3-months post-treatment. Results using the UV spot filter, feature count decreased from 706 to 631 and percentile reduced from 83% to 39%. Spot filter produced the same percentile of 9% for all photos affirming the VISIA’s efficacy in detecting UV damage-related areas. This study enhances patients’ understanding of 5-FU’s effectiveness on their AKs and provides a positive example of treatment success for future patient education and treatment adherence.
Provider-Related and Demographic Determinants in Circumcision Mishaps: A Retrospective Study from Ho Teaching Hospital, Ghana (Preprint)
Authors: Obeng Frank , APPIAH BOAKYE SYLVESTER
Published: September 2024

BACKGROUND

Introduction:
The success of circumcision depends primarily on the skill-level or level of supervision of the provider; but also on some key physical and socio-demographic features of the client being circumcised. In Ghana, both medical and traditional practitioners perform circumcisions, leading to variable outcomes. This study examines demographic and provider-related factors influencing circumcision outcomes in the Volta Region of Ghana.

OBJECTIVE

Objective:
To analyse the impact of circumcision provider skill-level, and some socio-demographic features of clients on circumcision outcomes; as a way of identifying common demographic and provider-related determinants of circumcision mishaps.

METHODS

Methodology:
A five-year retrospective study was conducted at Ho Teaching Hospital. Data on demographic and clinical factors, provider characteristics, and outcomes were extracted using a structured Ms Excel sheet. Bivariate and multivariate regression analyses were performed to assess the relationship between provider factors and circumcision outcomes, all at the 5% level of statistical significance.

RESULTS

Results:
Of 186 circumcisions, 33 (17.74%; 12.4% anatomic and 4.34%, non-anatomic). The mishaps included incomplete circumcision (43.48%), post-circumcision bleeding (21.74%), urethrocutaneous fistula (13.04%), and infections. Midwives-as-circumcisers and traditional circumcisers (Wanzams) had higher complication rates (13.3% and 60.0% respectively). Doctors had the lowest complication rate (3.4%). Age range of the clients was 1 week to 28 years, with a mean age of 11 months, and a standard deviation of 10 months. Most clients were aged 1 month to 1 year (41.4%) and had parents primarily engaged in service and manual labour occupations (47.3%). Most of the parents had secondary education (52.15%), were Christians (68.8%), of Ewe ethnicity (82.8%), Ghanaian nationality (95.7%), and resided in Ho and its surroundings (69.9%)

The demographic determinants of risk of circumcision mishaps in this study includes: Age of child: χ² = 48.9990, p = 0.000; highest Educational level of parent: χ² = 10.8811, p = 0.012; Occupation of parent: χ² = 44.7225, p = 0.013 and Residence: χ² = 33.7421, p = 0.000. Religion: χ² = 5.2154, p = 0.448 and Ethnicity: χ² = 8.3792, p = 0.253(were not statistically significant). The provider-related determinants include, provider skill-level; χ² =18.5119, p-value = 0.047 and the provider facility; χ²=26.04, p = 0.000.

CONCLUSIONS

Conclusion:
The demographic and provider-related determinants of circumcision complications among the Ghanaian circumcising population include: provider skill-level, provider facility, the age of circumcised client, occupation, educational level and residence of parents. These identified determinants will be aggregated into risk-stratification and mitigation nomograms or digital risk calculators, as tools for public health prevention, in future research.
Artificial intelligence in nephrology: revolutionizing diagnosis, treatment, and patient care
Authors: Eskandar Kirolos
Published: September 2024

Artificial intelligence (AI) is rapidly transforming the landscape of nephrology, offering innovative solutions that enhance diagnosis, treatment, and patient care. This literature review explores the current and potential applications of AI across various domains within nephrology. We discuss AI-driven advancements in early diagnosis, personalized treatment planning, renal replacement therapy, and transplant nephrology. Furthermore, we examine how AI enhances patient care through remote monitoring, telehealth, and virtual assistants. While the promise of AI is immense, this review also addresses the ethical, regulatory, and technical challenges that accompany its integration into clinical practice. By highlighting the transformative potential of AI in nephrology, we underscore the need for continued research and collaboration to fully realize its benefits in improving kidney health outcomes.
Consideration of a family case of X-linked hypophosphatemia through the prism of modern diagnostic and treatment methods
Authors: Vakulenko L.I.
Published: September 2024

Background. X-linked hypophosphatemia is the most common form of hereditary vitamin D-resistant rickets. Today, there is a late diagnosis, later treatment start and a significant deterioration in the quality of life of patients with X-linked hypophosphatemia. The aim of the study is to use a clinical case as an example in order to draw attention to the problem of X-linked hypophosphatemia and consider traditional and novel approaches to the diagnosis and the­rapy. Materials and methods. We analyzed a family case of ­X-linked hypophosphatemia in a 4-year-old boy. Results. Based on the analysis of a family case, modern approaches to clinical, laboratory and instrumental diagnosis recommended by international clinical guidelines for the diagnosis and treatment of X-linked hypophosphatemia are considered. The causes for late diagnosis, advantages and disadvantages of traditional therapy are analyzed. Treatment was adjusted including phosphate and active vitamin D preparations, ta­king into account international clinical guidelines. The latest data are presented on the treatment of X-linked hypophosphatemia with biological therapy using burosumab. The results of short-term stu­dies on the efficacy and safety of burosumab in children and adults are described. Conclusions. X-linked hypophosphatemia is a complex hereditary tubulopathy requiring timely diagnosis, treatment and thorough patient management by a multidisciplinary team of doctors. Once X-linked hypophosphatemia is suspected, a clinical, laboratory and instrumental examination of a patient should be carried out in accordance with international recommendations. Although traditional therapy has limited therapeutic efficacy and side effects, its early initiation is associated with better outcomes. A significant progress in the treatment of hypophosphatemic vitamin D-resistant rickets was achieved due to the biological therapy with burosumab aimed at its pathophysiological mechanisms. The profile of burosumab effects allows this therapy to be considered life-saving.
Utility of Genetic Testing in Adults with CKD
Authors: Schott Clara , Lebedeva Victoria , Taylor Cambrie , Abumelha Saeed , Roshanov Pavel S. , Connaughton Dervla M.
Published: September 2024

Key Points

Diagnostic yield of genetic testing in adults with CKD is 40%.

Risk factors including positive family history and extra-kidney features associate with higher diagnostic yield, although young age at testing did not.

Seventeen percent of patients who received a genetic diagnosis were reclassified into a different phenotype after testing.

Background

Clinical and pathological confirmation of the diagnosis for CKD has limitations, with up to one third of individuals remaining without a formal diagnosis. Increasingly, data suggest that these limitations can be overcome by genetic testing. The objective of this study was to estimate the diagnostic yield of genetic testing in adults with CKD.

Methods

Cohort studies that report diagnostic yield of genetic testing in adults with CKD published in PubMed or Embase between January 1, 2005, and December 31, 2023, were included. The Joanna Briggs Institute critical appraisal tool for prevalence studies was used to assess bias. Duplicate independent data extraction and a meta-analysis of proportions using generalized linear mixed models were completed.

Results

We included 60 studies with 10,107 adults with CKD who underwent genetic testing. We found a diagnostic yield of 40% (95% confidence interval, 33 to 46); yield varied by CKD subtype with the highest yield of 62% (95% confidence interval, 57 to 68) in cystic kidney disease. Positive family history and presence of extra-kidney features were associated with higher diagnostic yield. Reclassification of the before testing diagnosis after a positive genetic testing result occurred in 17% of the solved cohort. Six studies showed the clinical benefits of genetic testing including cascade testing for family members and treatment changes.

Conclusions

Overall, we show that genetic testing is informative in a high proportion of clinically selected adults with CKD. The study was limited by heterogeneity in reporting, testing technologies, and cohort characteristics.

Clinical Trial registry name and registration number:

International prospective register of systematic reviews (CRD42023386880).
ANTIOXIDANT ACTIVITY OF FLAVONOID RICH FRACTION OF (VERNONIA AMYGDALINA DELILE.) LEAVES
Authors: ROSALINA VIONA , HASIBUAN POPPY ANJELISA ZAITUN , SATRIA DENNY , MEIYANTO EDY , PUTRA DEDDI PRIMA , CHATRI MORALITA , SEPTISETYANI ENDAH PUJI
Published: September 2024

Objective: Atoms that are unstable and harmful to other molecules are referred to as free radicals. Flavonoid molecules have the ability to act as antioxidants, which can help avoid oxidative stress brought on by the high levels of free radicals that are found in the body. Antioxidants are chemicals that bind to free radicals and neutralize oxidized substances by giving electrons. The main objective of this comprehensive investigation was to assess and quantify the extent of antioxidant activity manifested by fractions abundant in flavonoids extracted from Vernonia amygdalina Del.
Methods: Refluxing n-hexane solvent and then continuing with methanol were the steps that taken in the process of extracting Vernonia amygdalina. The methanol extract was subjected to fractionation utilizing the liquid-liquid fractionation method, employing a series of solvents to isolate distinct fractions with varying chemical compositions. After determining the overall flavonoid content of each extract and fraction, an evaluation was conducted on the antioxidant activity of the samples containing the maximum flavonoid content.
Results: The dichlormethane fraction had the highest flavonoid content with 69.56±0.22 mg/g QE. Then the DCM fraction was tested for antioxidant activity, and the results obtained for the DPPH method were 117.33±0.56 and the CUPRAC method was was 84.80±0.73.
Conclusion: The results showed that DCM fraction is the highest flavonoid fraction and exhibits potent antioxidant properties.
ACUTE TOXICITY EVALUATION OF CURCUMA DOMESTICA VAHL. RHIZOME VCO CURCUMINOID EXTRACT
Authors: ARDANA TASYA , YUANDANI  , SATRIA DENNY , LUX PUTRA EFFENDY DE , MUHAMMAD MAHATIR , ROSIDAH
Published: September 2024

Objective: Recently, Curcuma domestica has been reported to have various pharmacological activities, such as antioxidant, anti-inflammatory and antifungal activities. The current study was conducted to evaluate the safety of C. domestica VCO Curcuminoid extract in short term and determine its curcumin content.
Methods: Turmeric extract in VCO was prepared using a Microwave Assisted Extract (MAE) method, acute toxicity tests were carried out using 15 female mice divided into 5 preliminary test groups with 5, 50, 300, 1000, 2000 mg/KgBW doses. Furthermore, 10 female mice divided into 2 groups with 1000, 2000 mg/Kg BW doses as the main test. At the end of the experiments, the blood hematology, blood clinical biochemistry, and histopathology examination were performed.
Results: Turmeric rhizome curcuminoid VCO extract at the dose of 2000 mg/Kg BW indicated signs of toxic symptoms, including diarrhea, changes in fur and skin and walking on the stomach. There are significant difference among the data of blood biochemistry and blood hematology of the CMC-Na group, with extract at the doses of 1000 mg/KgBW.
Conclusion: It can be inferred that the turmeric rhizome VCO curcuminoid extract induces acute toxicity at a dose of 2000 mg/KgBW.
A RANDOMIZED CONTROLLED TRIAL: MISLEADING LATERAL EPICONDYLITIS
Authors: JOSHI JAYESH , KHAN JAFAR , VYAS KAPIL , SHAH VIRALKUMAR A.
Published: September 2024

Objective: To rule out the presence of inflammation around the lateral epicondyle in patients diagnosed with lateral epicondylitis and have at least 3 mo of history from onset of symptoms.
Methods: A total of 30 subjects were taken, both males and females between the age group 25 to 55 to observe the changes over and near the lateral epicondyle along with tendons of ECRB, ECB, Triceps, and with all insertional sites over and near the lateral epicondyle for inflammation under a guidance and supervision of a radiologist with help of MSK USG.
Results: No inflammatory changes were found in any of the subjects regardless of duration, age and signs and symptoms.
Conclusion: It can be concluded that lateral epicondylitis is a misnomer and there is no to assess the condition to rule out pathophysiology and management.
EFFECT OF RANITIDINE ON HYPOGLYCAEMIC ACTIVITY OF GLIPIZIDE IN RABBITS
Authors: GHOLVE RANJEETA , JOHN SAM , SHEP DHANESHWAR , RAMAVAT MANISH
Published: September 2024

Objective: To study the effect of Ranitidine (H2 receptor antagonist) in combination with Glipizide on the blood sugar level in rabbits.
Methods: Six albino rabbits were taken for the study. Glipizide was administrated to each rabbit as a single drug therapy on day 1, while was co-administrated with Ranitidine to each rabbit as a combinational drug therapy on day 7. Ranitidine was administrated to each rabbit from day 2 to day 6 as a single drug therapy. Blood sugar levels were estimated on day 1 and on day 7 at 0, 1, 2, 4, and 6 h.
Results: The mean blood sugar level readings at 0, 1, 2, 4 and 6 h on day 1 were 90.9, 78.4, 67.2, 60.2 and 67.5 mg% and on day 7 were 90.3, 77.01, 63.3, 55.7 and 64 mg% respectively. When mean blood sugar level on day 1 and day 7 were considered, there was a significant reduction in blood sugar level at 2, 4 and 6 h but there was no significant fall in blood sugar level at 0 and 1 hour after co-administration of Glipizide and Ranitidine.
Conclusion: Ranitidine, when co-administered with glipizide, significantly increases the hypoglycaemic action of glipizide.
TO COMPARE THE FUNCTIONAL OUTCOME IN PATIENTS OF FLOATING KNEE WITH AND WITHOUT MRI
Authors: AGARWAL SAUMYA , SINGH HARPREET , SHARMA ANAMENDRA , GUPTA KALIKA
Published: September 2024

Objective: A floating knee injury involves simultaneous ipsilateral fractures of the femur and tibia, which disconnect the knee from the rest of the limb and can include both intra-articular and extra-articular fractures. Optimal clinical outcomes are achieved through surgical stabilization of both fractures and early rehabilitation. Historically, the incidence of floating knee injuries has been underestimated, but the use of Magnetic Resonance Imaging [MRI] and arthroscopy has increased their detection. Soft tissue injuries associated with these fractures can be missed during clinical examination due to tenderness and swelling, making immediate MRI scans a valuable diagnostic tool. This study aimed to compare the functional outcomes of patients with floating knee injuries who underwent MRI for soft tissue injuries and those who did not undergo MRI.
Methods: The study, conducted at a tertiary care center from May 2021 to April 2024, involved 100 patients with floating knee injuries who underwent MRI assessments for soft tissue injuries. Additionally, a retrospective analysis was performed on 25 patients treated between November 2018 and October 2020, who did not receive MRI evaluations. The functional outcomes for all patients were assessed using the Karlstrom Olerud criteria.
Results: Out of the 100 patients with floating knee injuries who underwent MRI, seventy-two were found to have meniscus or ligament injuries. According to the Karlstrom and Olerud criteria, the outcomes were as follows: 10 patients (8%) had excellent results, 56 patients (44.8%) had good results, 36 patients (36%) had fair results, and 6 patients (4.8%) had poor outcomes. Patients who underwent MRI had better functional outcome at 1 y and 2 y follow-up.
Conclusion: Our aim is to initiate timely and accurate treatment by comprehensively addressing all associated injuries, including previously overlooked ligament damage around the knee. Factors such as articular involvement, soft tissue damage, and the presence of concomitant injuries significantly influence functional outcomes. MRI plays a crucial role in diagnosing associated soft tissue injuries, allowing for immediate intervention and resulting in better functional outcomes.
Исследование широкого класса органических соединений методом хромато-масс-спектрометрии
Authors: Астахов А.В.
Published: September 2024

Хромато-масс-спектрометрия – аналитический метод, основанный на сочетании возможностей хроматографии по разделению веществ и масс-спектрометрии, использующей для качественного и количественного определения отдельных компонентов в сложных смесях их спектральные характеристики. Приведены краткая историческая справка развития масс-спектрометрии, типы основных узлов масс-спектрометра и описание работы хромато-масс-спектрометра на примере прибора «Кристаллюкс 4000М»-«Маэстро-αМС», а также его технические характеристики. Перечислены области применения хромато-масс-спектрометра и некоторые конкретные методики измерения.
Integral Review on Pulmonary Tuberculosis
Authors: S Role Shital . , M Mane Anant . , B Parsewar Hrushikesh . , V Nidwanche Shruti .
Published: September 2024

Abstract: Since tuberculosis is a chronic, systemic occupational disease that is common in developing nations, it is an important public health concern. The primary pulmonary pathogen that causes disease by infection is Mycobacter tuberculosis. Pathogens can cause disease by infecting almost any part of the body. The primary goal of the study was to raise awareness and provide information about tuberculosis infection, which is caused by bacteria isolated from the host's implementary cells. This infection can progress to a highly contagious stage, at which point the patient may experience symptoms such as bloody coughing, fever, night sweats, and weight loss. only those with infectious active pulmonary tuberculosis. The purpose of that quick study was to broaden students' and society members' knowledge. India has the highest rate of tuberculosis deaths worldwide, with about 600 deaths each day from the disease. The infectious disease that kills the greatest number of adults in India is tuberculosis. In 2012, the Indian government designated tuberculosis (TB) as a notifiable ailment, meaning that any physician who suspects a patient has TB must report the case to the government. TB control and treatment are covered by a national program in India that provides free treatment to all TB cases. The bacillus calmette guerin (BCG) vaccination is widely used globally to prevent the diagnosis of tuberculosis in infants and early children, even though it was unable to stop the global TB pandemic. Novel vaccinations are being developed in an attempt to increase immunisation effectiveness.
Optimizing Mutual Fund Selection with Fuzzy Sharpe Ratio: An Empirical Study of Indian Markets
Authors: Brindha Dr. R. , Sathiyapriya Dr. S. P. , Viji S. , Bagyalakshmi P. Devi, K. , John P. Stanley , Manopriya V. , Nithya S.
Published: September 2024

Abstract: Mutual funds are widely recognized for their ability to offer diversification and professional management, making them a popular choice for investors. This study explores the evaluation of mutual fund performance using advanced metrics, specifically focusing on fuzzy logic and the Fuzzy Sharpe Ratio. A comprehensive literature review highlights recent advancements, including the integration of machine learning and fuzzy logic models. The study utilizes numerical data from the Bombay Stock Exchange for the period from January 1, 2023, to August 31, 2024, to apply the Fuzzy Risk-Adjusted Return method. The results reveal that the Canara Robeco Bluechip Equity Fund ranks highest according to the Fuzzy Sharpe Ratio, indicating its superior performance compared to other funds, such as the HSBC Large Cap Fund. This analysis underscores the effectiveness of fuzzy logic in enhancing mutual fund evaluations and recommends the Canara Robeco Bluechip Equity Fund as the optimal choice for investors and fund managers.
Prototipe Robot Automatic Guided Vehicle (AGV) Line Follower Dengan Metode Kendali Proportional Integral Derivative (PID)
Authors: Noviardi M. Rizki , Pangaribowo Triyanto , Yuliza Yuliza , Supegina Fina
Published: September 2024

Era Revolusi Industri 4.0 telah semakin pesat, ditunjukkan dengan semakin banyak dan maraknya teknologi yang telah diciptakan dalam berbagai aspek kehidupan. Salah satu bentuk implementasi yang saat ini sedang dikembangkan di era revolusi industri 4.0 yaitu untuk mengganti beberapa peran manusia dengan menggunakan robot. Salah satu robot yang sudah mulai digunakan di beberapa perusahaan khususnya di negara maju adalah robot jenis AGV (Automatic Guided Vehicle). Robot AGV adalah robot yang digunakan untuk mengangkut barang dari suatu titik tempat awal menuju titik tujuan secara otomatis tanpa dikendalikan oleh operator. Kemampuan robot yang dapat dioperasikan tanpa operator ini juga dapat mengurangi tingkat kecelakaan kerja yang disebabkan dari kelalaian pekerja. Perancangan sistem alat yang dibuat pada penelitian ini yaitu berupa prototipe robot AGV dengan menggunakan 2 buah motor DC untuk menggerakkan 2 buah roda yang dikendalikan oleh driver motor L298N. Mikorokontroler yang digunakan adalah Arduino nano dan untuk sensor yang digunakan adalah sensor cahaya yang digunakan untuk mendeteksi garis lintasan robot. Selain 1 buah robot AGV, pada perancangan alat yang dibuat juga akan dibuat sebuah sistem yang digunakan pada area produksi dan warehouse, yang masing-masing terdiri dari mikrokontroler Arduino nano, modul wireless NRF24L01 dan ada tambahan sensor IRE18-D50NK pada warehouse dan push button pada area produksi. Berdasarkan data percobaan 10 kali pengujian yang dilakukan diperoleh persentase tingkat keberhasilan sebesar 90%. Terdapat 1 kali kegagalan, dimana robot tidak berhasil kembali ke home. Hal tersebut dikarenakan sensor yang gagal mendeteki persimpangan.
Rancang Bangun Otomatisasi Hidroponik Deep Flow Technique Menggunakan Logika Fuzzy Sugeno Berbasis Internet Of Things
Authors: Dani Akhmad Wahyu , Putri Farrah Aisyah , Sirait Fadli , Attamimi Said
Published: September 2024

Penuruan kualitas lingkungan hidup merupakan sebuah permasalahan yang sedang di hadapi oleh masyarakat. Pembangunan kawasan perumahan yang tidak memperhatikan Ruang Terbuka Hijau memberi dampak terhadap penurunan kualitas lingkungan hidup. Untuk itu, pekarangan rumah dimanfaat guna meningkatkan kualitas lingkungan hidup masyarakat. Namun dengan lokasi rumah yang berada di perkotaan belum tentu menyediakan pekarangan yang luas untuk bercocok tanam. Untuk itu diperlukan metode penanaman yang lebih berkelanjutan yang dikenal dengan hidroponik. Hidroponik merupakan metode budidaya tanaman dengan menggunakan sejumlah air yang kaya akan nutrisi sebagai media tanamnya. Hidroponik termasuk smart gardening dimana dapat diintegrasikan pada IoT, sehingga penelitian ini berfokus pada pembuatan otomatisasi hidroponik menggunakan metode logika fuzzy berbasis IoT. Prototipe ini berfungsi untuk dan mengatur jumlah air, nutrisi dan pH pada tangki nutrisi berdasarkan hasil pembacaan sensor. Untuk menghasilkan keluaran yang terkuantisasi, metode Logika Fuzzy Sugeno digunakan pada sistem ini. Berdasarkan hasil dari fuzzifikasi dan inferensi pada metode tersebut, menghasilkan nilai keluaran pada motor pompa air, motor pompa nutrisi, motor pompa pH Up dan motor pompa pH Down berupa waktu dengan satuan detik. Dengan menerapkan logika fuzzy pada pengendalian nutrisi pada tanaman hidroponik, pertumbuhan tanaman menggunakan kendali logika fuzzy lebih optimal dibandingkan tanpa kendali logika fuzzy. Kemudian respon waktu pada pengendalian tinggi air mencapai kestabilan yaitu 41 detik. Respon waktu pada pengendalian TDS mencapai kestabilan yaitu 51,96 detik. Respon waktu pada pengendalian pH mencapai kestabilan yaitu 5,48 detik. Nilai output pada Arduino memiliki keakuratan sebesar 99,77% terhadap nilai output yang disimulasikan menggunakan Matlab. Prototipe ini dapat dipantau secara jarak jauh dengan menggunakan platform ThingSpeak dimana dalam pengiriman data dari Arduino ke ThingSpeak membutuhkan waktu 11,2 detik.
Game Edukasi Pengenalan Batik Nusantara Berbasis HTML5 Menggunakan Metode Game Development Life Cycle
Authors: Iman Fauzi Nur , Farida Ida
Published: September 2024

Seiring perkembangan zaman menyebabkan banyaknya kebudayaan di indonesia mulai terabaikan, salah satunya adalah kebudayaan batik. Kita baru menyadari bahwa budaya Indonesia patut dilestarikan setelah budaya kita mendapatkan pengakuan-pengakuan dari negara lain. Oleh karena itu penulis memberikan solusi berupa game edukasi pengenalan batik nusantara, sebagai salah satu cara media untuk mempermudah generasi muda memahami materi tentang batik nusantara yang menarik dan interaktif. Game edukasi pengenalan batik nusantara ini disajikan dalam bentuk visual 2D dan dibuat dengan game engine Gdevelop serta menggunakan metode Game Development Life Cycle (GDLC). Penelitian ini akan menghasilkan sebuah media pembelajaran edukatif yaitu Game edukasi pengenalan batik nusantara berbasis HTML5.
Nikolay Karamzin’s History in Fyodor Dostoevsky’s Novel The Idiot
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Podosokorsky Nikolay N.
Published: September 2024

The article explores the influence of Nikolay Karamzin’s History of the Russian State (1818–1829) on Fyodor Dostoevsky’s novel The Idiot (1868–1869). Karamzin’s historical and literary work significantly shaped Dostoevsky’s worldview from childhood and remained highly valued by him in adulthood. Dostoevsky owned a copy of Karamzin’s multi-volume work in his library and, according to acquaintances, knew it “almost by heart.” The article demonstrates that the mention of Karamzin’s History in the opening scene of The Idiot should be understood in the context of the heightened public interest in Karamzin during the centenary of his birth, celebrated in Russia in December 1866. This interest persisted during the years when The Idiot was written and published. Karamzin was regarded by several Russian writers and public figures in the late 1860s, including critic Nikolay Strakhov, who was close to Dostoevsky at that time, as a moral guide for contemporaries and as an ideal of a “beautiful man.” This image resonates with that of Prince Lev Myshkin, to whom the know-it-all official Lukyan Lebedev advises immersing oneself in Karamzin’s History. The article also clarifies and supplements previous research on the connection between Dostoevsky’s The Idiot and Karamzin’s History. Special attention is given to comparing The Idiot with Karamzin’s autobiographical novel A Knight of Our Time (1802–1803), whose main character, like Dostoevsky’s hero, is named Leon and shares Don Quixote-like qualities.
La Integración de las migraciones medievales en Europa
Authors: Irazola Agustín Andrés
Published: September 2024

The peoples traditionally known in historiography as barbarians arrived in Europe in various waves between the 4th and 13th centuries. This article aims to demonstrate that the decisive factor for the integration and civilization of the diverse peoples who entered the Empire was Christianity, and that Rome would not have had the capacity to absorb them on its own. To support this, we will examine certain characteristics of Rome's expansion and the intrinsic principles of Christianity that enabled it to civilize the invaders.
Adaptación y resiliencia en jefes de hogar después de un desastre natural
Authors: Rodríguez Suárez Erika Yamile , Moreno Carmona Norman Darío
Published: September 2024

The objective of this research is to understand how adaptive processes have allowed the development of resilience in 4 heads of household victims of the avalanche in the municipality of Salgar on May 18, 2015. The research approach is phenomenological and the research strategy is the case study. The technique used was the semi-structured interview and the participants consisted of two men and two women. In the results it was found that adaptive processes are structured from social and individual changes and the mobilization of support networks. And the development of resilience was related to I have (social support), I can (coping strategies) and I am (interpersonal skills), faith support and community support. And it was identified that governmental support in material and social fabric reconstruction is fundamental in the development of resilience.
Biochemical and toxicological evaluation of Solanum viarum fruit extract on Dugesia tigrina
Authors: Schaly Felipe , Braguini Welligton
Published: September 2024

Solanum viarum has alkaloid-rich fruits. We evaluated the antioxidant and chelating activities of the aqueous extract fraction (AEF) from S. viarum fruits and its effects on the brown planarian Dugesia tigrina. The AEF demonstrated an iron-chelating effect comparable to ascorbic acid but lower than EDTA and a significant reducing power. The 96-h LC50 for planarians was 1.22 g/L. At a concentration of 0.50 g/L, the AEF reduced planarian locomotor velocity by 34.7%, while decreasing fecundity and fertility by 98.4% and 96.7%, respectively, leading to a significant decline in the number of cocoons and emerging planarians. Cocoon hatching time was increased at all AEF concentrations. Planarians exposed to 0.50 g/L AEF for 14 days showed a 62.3% reduction in glycogen content. After 14 days, catalase was inhibited at all concentrations, with 83.2% inhibition at 0.50 g/L. Superoxide dismutase (SOD) increased by 60.8% and 59.9% after 24 h and 14 days, respectively, at 0.50 g/L AEF. Catalase (CAT) was stimulated by 72.1% and 44% at 0.10 and 0.25 g/L AEF, respectively, but inhibited by 25.2% at 0.50 g/L after 24 h. The iron-chelating activity of the AEF reduces iron availability for catalase, an irondependent enzyme, leading to its inhibition, while also limiting Fenton and Haber-Weiss reactions, resulting in hydrogen peroxide accumulation and subsequent stimulation of SOD under prolonged exposure. Acetylcholinesterase (AChE) was stimulated by 40.6% and 44.8% after 24 h and 14 days, respectively, at 0.50 g/L AEF. These findings show that S. viarum is harmful to planarians and may pose environmental risks, highlighting the need for toxicity assessments in other species.
Valorisation of energy plant Arundo donax cultivated in Serbia for biosorption of cobalt ions from an aqueous solution: Kinetic aspect
Authors: Perendija Jovana , Milosevic Dragana , Popovic Mina , Dzeletovic Zeljko , Kovac Sabina , Grbovic-Novakovic Jasmina , Cvetkovic Slobodan
Published: September 2024

Metal ions can be eliminated from aqueous solutions using biosorbent, a substance made from plant biomass. This study investigated the potential use of Arundo donax stems as a cheap, natural biosorbent to remove cobalt ions (Co2+) from an aqueous solution. The biosorbent was characterized by the chemical composition analysis (cellulose, hemicellulose, and lignin), the point of zero charge (pHPZC), by scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction analysis, and Fourier-transform infrared spectroscopy. According to the experimental data of kinetic studies, the equilibrium condition of Co2+ adsorption was attained 360 min after the biosorption started. The pseudo-first, pseudo-second, Elovich, and intra-particle diffusion models were used to model the kinetic experimental data. The best compliance was obtained with the pseudo-first order kinetic model, considering the highest value of the coefficient of determination R2 (0.996) and the lowest chi-square (?2) value (0.757). The findings of this study can be applied to the design of batch biosorption systems for the removal of Co2+ ions in real industrial systems.
Bolzano’s theory of grounding
Authors: Panajotov Milos
Published: September 2024

The aim of this article is to examine the aspects of Bolzano?s theory of
grounding that have significantly anticipated contemporary discussions of
grounding and have further provided impetus for the ?rediscovery? of
Bolzano?s work. Therefore, for each presented segment of his teachings, we
will establish connections and parallels with the contemporary theories of
grounding. Finally, we will delve into considerations of the significance
and place of Bolzano?s insights in the context of recent debates about the
history of the concept of grounding.