bluuebunny/crossref_metadata_2025 huggingface dataset:
High-throughput homogenous assay for the direct detection of Listeria monocytogenes DNA
Authors: Armstrong Cheryl M. , Capobianco Joseph A. , Nguyen Sarah , Guragain Manita , Liu Yanhong
Published: March 2024

The Amplified Luminescent Proximity Homogenous Assay-linked Immunosorbent Assay (AlphaLISA) is known for detecting various protein targets; however, its ability to detect nucleic acid sequences is not well established. Here, the capabilities of the AlphaLISA technology were expanded to include direct detection of DNA (aka: oligo-Alpha) and was applied to the detection of Listeria monocytogenes. Parameters were defined that allowed the newly developed oligo-Alpha to differentiate L. monocytogenes from other Listeria species through the use of only a single nucleotide polymorphism within the 16S rDNA region. Investigations into the applicability of this assay with different matrices demonstrated its utility in both milk and juice. One remarkable feature of the oligo-Alpha is that greater sensitivity could be achieved through the use of multiple acceptor oligos compared to only a single acceptor oligo, even when only a single donor oligo was employed. Additional acceptor oligos were easily incorporated into the assay and a tenfold change in the detection limit was readily achieved, with detection limits of 250 attomole of target being recorded. In summary, replacement of antibodies with oligonucleotides allows us to take advantage of genotypic difference(s), which both expands its repertoire of biological markers and furthers its use as a diagnostic tool.
Digital finance, innovation transformation, and resilient city growth
Authors: Zhang Wenwu , Wang Jinguo , Jin Hongkui
Published: March 2024

Digital finance is a pivotal catalyst for a contemporary economic system and assumes a significant auxiliary function in the establishment of resilient urban centers. This study empirically examines the enabling influence of digital finance on resilient cities using panel data from 287 prefecture-level cities and above in China between 2011 and 2020. The analysis is based on the mechanisms of innovation and transformation. The importance of digital finance in facilitating the development of resilient cities has been observed, with a specific emphasis on its impact on enhancing the adaptive capacity and growth resilience of urban areas. The utilization of digital finance has the potential to expedite the process of transforming urban industrial structures, invigorating innovation and entrepreneurial activities, and serving as a significant catalyst for the development of resilient cities. The analysis of heterogeneity reveals that various aspects of digital finance have varying degrees of influence on urban resilience. Specifically, the depth of utilization of digital finance exerts the most significant impact, followed by the level of digitalization, while the extent of coverage has the least effect. Furthermore, when considering regional distribution, the promotion effect of digital finance on resilient cities diminishes gradually from the eastern to the central and western regions.
Role of Rad18 in B cell activation and lymphomagenesis
Authors: Kalweit Kevin , Gölling Vanessa , Kosan Christian , Jungnickel Berit
Published: March 2024

Maintenance of genome integrity is instrumental in preventing cancer. In addition to DNA repair pathways that prevent damage to DNA, damage tolerance pathways allow for the survival of cells that encounter DNA damage during replication. The Rad6/18 pathway is instrumental in this process, mediating damage bypass by ubiquitination of proliferating cell nuclear antigen. Previous studies have shown different roles of Rad18 in vivo and in tumorigenesis. Here, we show that B cells induce Rad18 expression upon proliferation induction. We have therefore analysed the role of Rad18 in B cell activation as well as in B cell lymphomagenesis mediated by an Eµ–Myc transgene. We find no activation defects or survival differences between Rad18 WT mice and two different models of Rad18 deficient tumour mice. Also, tumour subtypes do not differ between the mouse models. Accordingly, functions of Rad18 in B cell activation and tumorigenesis may be compensated for by other pathways in B cells.
Association among childhood adversity and susceptibility to interference during varying salience: two studies in healthy males
Authors: Amedick Greta , Krylova Marina , Mayer Kathrin , Izyurov Igor , Herrmann Luisa , Martens Louise , Kasties Vanessa , Heller Johanna , Li Meng , van der Meer Johan , Croy Ilona , Engert Veronika , Walter Martin , Colic Lejla
Published: March 2024

Childhood adversity, a prevalent experience, is related to a higher risk for externalizing and internalizing psychopathology. Alterations in the development of cognitive processes, for example in the attention-interference domain may link childhood adversity and psychopathology. Interfering stimuli can vary in their salience, i.e. ability to capture attentional focus, and valence. However, it is not known if interference by salience or valence is associated with self-reported adversity. In two independent study samples of healthy men (Study 1: n = 44; mean age [standard deviation (SD)] = 25.9 [3.4] years; Study 2: n = 37; 43.5 [9.7] years) we used the attention modulation task (AMT) that probed interference by two attention-modulating conditions, salience and valence separately across repeated target stimuli. The AMT measures the effects of visual distractors (pictures) on the performance of auditory discrimination tasks (target stimuli). We hypothesized that participants reporting higher levels of childhood adversity, measured with the childhood trauma questionnaire, would show sustained interference in trials with lower salience. Due to conflicting reports on the valence-modulation, we tested the valence condition in an exploratory manner. Linear mixed models revealed an interaction between reported childhood adversity and the salience condition across tone presentations in both study samples (Sample 1: p = .03; Sample 2: p = .04), while there were no effects for the valence condition across both studies. Our study suggests that higher self-reported childhood adversity is related to faster processing of target cues during high salience, but slower during low salience conditions. These results hint to the mechanisms linking childhood adversity and psychopathological symptoms in the attentional domain.
Voluntary exercise preserves visual function and reduces inflammatory response in an adult mouse model of autosomal dominant retinitis pigmentosa
Authors: Bales Katie L. , Karesh Austin M. , Hogan Kelleigh , Chacko Alicia S. , Douglas GianMarco L. , Feola Andrew J. , Nickerson John M. , Pybus Alyssa , Wood Levi , Boatright Jeffrey H. , Pardue Machelle T.
Published: March 2024

Whole-body physical exercise has been shown to promote retinal structure and function preservation in animal models of retinal degeneration. It is currently unknown how exercise modulates retinal inflammatory responses. In this study, we investigated cytokine alterations associated with retinal neuroprotection induced by voluntary running wheel exercise in a retinal degeneration mouse model of class B1 autosomal dominant retinitis pigmentosa, I307N Rho. I307N Rho mice undergo rod photoreceptor degeneration when exposed to bright light (induced). Our data show, active induced mice exhibited significant preservation of retinal and visual function compared to inactive induced mice after 4 weeks of exercise. Retinal cytokine expression revealed significant reductions of proinflammatory chemokines, keratinocyte-derived chemokine (KC) and interferon gamma inducible protein-10 (IP-10) expression in active groups compared to inactive groups. Through immunofluorescence, we found KC and IP-10 labeling localized to retinal vasculature marker, collagen IV. These data show that whole-body exercise lowers specific retinal cytokine expression associated with retinal vasculature. Future studies should determine whether suppression of inflammatory responses is requisite for exercise-induced retinal protection.
Comparative efficacy of different types of exercise modalities on psychiatric symptomatology in patients with schizophrenia: a systematic review with network meta-analysis
Authors: Cui Wenlai , Liu Zhitao , Liang Cheng , Zhao Zhizhi
Published: March 2024

This network meta-analysis investigated the effects of 8 types of physical exercises on treating positive symptoms, negative symptoms, general psychopathology, and the Positive And Negative Syndrome Scale (PANSS) total score in patients with schizophrenia. The methods adhered to PRISMA guidelines and used the Cochrane risk of bias tool for quality assessment, and Stata software for data analysis. Data were sourced from PubMed, Embase, Web of Science, and the Cochrane database up to August 15, 2023, following PICOS principles. A total of 25 studies including 1441 participants were analyzed. Results showed that resistance exercise seems to be effective for improving positive symptoms, while Yoga was more effective for negative symptoms. Low-intensity aerobic exercise was optimal for general psychopathology, and Yoga was effective in improving the PANSS total score. The study concluded that yoga and aerobic exercise demonstrated superior performance, but the impact of exercise on patients with schizophrenia is also influenced by individual factors and intervention dosages. Therefore, a pre-assessment of patients considering factors such as interests, hobbies, and physical capabilities is crucial for selecting appropriate exercise modalities.
The reproduction process of Gram-positive protocells
Authors: Kanaparthi Dheeraj , Lampe Marko , Krohn Jan-Hagen , Zhu Baoli , Hildebrand Falk , Boesen Thomas , Klingl Andreas , Phapale Prasad , Lueders Tillmann
Published: March 2024

Protocells are believed to have existed on early Earth prior to the emergence of prokaryotes. Due to their rudimentary nature, it is widely accepted that these protocells lacked intracellular mechanisms to regulate their reproduction, thereby relying heavily on environmental conditions. To understand protocell reproduction, we adopted a top–down approach of transforming a Gram-positive bacterium into a lipid-vesicle-like state. In this state, cells lacked intrinsic mechanisms to regulate their morphology or reproduction, resembling theoretical propositions on protocells. Subsequently, we grew these proxy-protocells under the environmental conditions of early Earth to understand their impact on protocell reproduction. Despite the lack of molecular biological coordination, cells in our study underwent reproduction in an organized manner. The method and the efficiency of their reproduction can be explained by an interplay between the physicochemical properties of cell constituents and environmental conditions. While the overall reproductive efficiency in these top-down modified cells was lower than their counterparts with a cell wall, the process always resulted in viable daughter cells. Given the simplicity and suitability of this reproduction method to early Earth environmental conditions, we propose that primitive protocells likely reproduced by a process like the one we described below.
Optimization by Box–Behnken design for environmental contaminants removal using magnetic nanocomposite
Authors: Buenaño Luis , Ali Eyhab , Jafer Ahmed , Zaki Shaima Haithem , Hammady Fathi Jihad , Khayoun Alsaadi Salima Baqir , Karim Manal Morad , Ramadan Montather F. , Omran Alaa A. , Alawadi Ahmed , Alsalamy Ali , Kazemi Ali
Published: March 2024

In this study, a CoO–Fe2O3/SiO2/TiO2 (CIST) nanocomposite was synthesized and utilized as an adsorbent to remove methylene blue (MB), malachite green (MG), and copper (Cu) from aqueous environments. The synthesized nanocomposite was characterized using field emission scanning electron microscopy (FE-SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and X-ray diffraction (XRD). Input parameters included pH (3–10), contact time (10–30 min), adsorbent amount (0.01–0.03 g), and pollutant concentration (20–60 mg L−1). The effects of these parameters on the removal process efficiency were modeled and optimized using the response surface methodology (RSM) based on the Box–Behnken design (BBD). The RSM-BBD method demonstrated the capability to develop a second-degree polynomial model with high validity (R2 ˃ 0.99) for the removal process. The optimization results using the RSM-BBD method revealed a removal efficiency of 98.01%, 93.06%, and 88.26% for MB, MG, and Cu, respectively, under optimal conditions. These conditions were a pH of 6, contact time of 10 min, adsorbent amount of 0.025 g, and concentration of 20 mg L−1. The synthesized adsorbent was recovered through five consecutive adsorption–desorption cycles using hydrochloric acid. The results showed an approximately 12% reduction from the first to the seventh cycle. Also, MB, MG, and Cu removal from real water samples in optimal conditions was achieved in the range of 81.69–98.18%. This study demonstrates the potential use of CIST nanocomposite as an accessible and reusable option for removing MB, MG, and Cu pollutants from aquatic environments.
The complete mitochondrial genome of Chibiraga houshuaii (Lepidoptera, Limacodidae) and its phylogenetic implications
Authors: Cai Yanpeng , Yin Aihui
Published: March 2024

Chibiraga is a mall East Asian genus in the family Limacodidae (slug-moths). The latter includes many agricultural pests. Mitochondrial genome analysis is an important tool for studying insect molecular identification and phylogenetics. However, there are very few mitogenome sequences available for Limacodidae species, and none for the genus Chibiraga at all. To explore the mitogenome features of Chibiraga and verify its phylogenetic position, the complete mitogenome of Chibiraga houshuaii was sequenced and annotated. The complete 15,487 bp genome encoded 37 mitochondrial genes, including 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, two ribosomal RNA (rRNA) genes, and a control region (CR). Most of the PCGs had typical ATN start codons and terminated with TAA or a single T residue. UUA (Leu2), AUU (Ile), UUU (Phe), AUA (Met) and AAU (Asn) were the five most frequently used codons. All tRNAs were folded into cloverleaf secondary structure, except for trnS1, which lacked the DHU arm. Phylogenetic analyses within the superfamily Zygaenoidea were performed based on multiple datasets from mitochondrial genes. The results showed that the families Phaudidae, Limacodidae and Zygaenidae were respectively recovered as monophyly; C. houshuaii was clustered in a clade with nettle type larvae in Limacodidae.
Ketotifen directly modifies the fibrotic response of human skin fibroblasts
Authors: Leong Edwin , Al-Bitar Haya , Marshall Jean S. , Bezuhly Michael
Published: March 2024

Fibrosis is a destructive, end-stage disease process. In the skin, it is associated with systemic sclerosis and scarring with considerable health burden. Ketotifen is a clinical antihistamine and mast cell stabilizer. Studies have demonstrated mast cell-dependent anti-fibrotic effects of ketotifen but direct effects on fibroblasts have not been determined. Human dermal fibroblasts were treated with pro-fibrotic transforming growth factor-β1 (TGFβ) followed by ketotifen or control treatments to determine direct effects on fibrotic fibroblasts. Ketotifen impaired TGFβ-induced α-smooth muscle actin gene and protein responses and decreased cytoskeletal- and contractility-associated gene responses associated with fibrosis. Ketotifen reduced Yes-associated protein phosphorylation, transcriptional coactivator with PDZ binding motif transcript and protein levels, and phosphorylation of protein kinase B. In a fibroblast-populated collagen gel contraction assay, ketotifen reduced the contractile activity of TGFβ-activated fibroblasts. In a murine model of bleomycin-induced skin fibrosis, collagen density and dermal thickness were significantly decreased in ketotifen-treated mice supporting in vitro findings. These results support a novel, direct anti-fibrotic activity of ketotifen, reducing pro-fibrotic phenotypic changes in fibroblasts and reducing collagen fibres in fibrotic mouse skin. Together, these findings suggest novel therapeutic potential and a novel mechanism of action for ketotifen in the context of fibrosis.
A new index to measure the uniformity of remolded loess
Authors: Wang Haike , Howard Ken , Peng Jianbing , Qian Hui , Gao Yanyan , Xu Panpan
Published: March 2024

The uniformity of remolded loess is crucial for engineering stability and in laboratory testing, as it affects physical and mechanical properties. It is important to have an index which can accurately and conveniently evaluate the uniformity of remolded loess. This study demonstrated and verified the feasibility of using hydraulic conductivity (K) as an indicator for evaluating the uniformity of remolded loess through laboratory experiments and theoretical analysis. In laboratory research, nine loess samples under different preparation conditions were meticulously prepared in duplicate, which were divided into three sets according to the whole dry density (WDD) of approximately 1.3 g/cm3, 1.4 g/cm3, and 1.5 g/cm3 respectively. For the nine duplicate samples, two procedures were performed for each of the sample. One is the uniformity analysis by cutting the soil column and weighing. The other is the hydraulic conductivity experiment. Results showed that sample uniformity is affected by sample preparation conditions, and there are differences in the uniformity of the same WDD samples. The values of K positively correlate with the degree of sample uniformity. In theoretical analysis, based on Darcy’s Law and Kozeny-Carman equation, it is found K is inversely proportional to the variance ($$\sigma^{2}$$

σ
2

) of the sample dry density. That is, K is positively proportional to the sample uniformity. Since K can be easily determined in the laboratory, the application of this new index in the field of geotechnical engineering makes it very convenient and simple to evaluate the uniformity of remolded loess.
Mouse auditory cortex sub-fields receive neuronal projections from MGB subdivisions independently
Authors: Wang Chi , Jiang Zhen-yu , Chai Jian-yuan , Chen Hong-suo , Liu Li-xia , Dang Tong , Meng Xian-mei
Published: March 2024

Mouse auditory cortex is composed of six sub-fields: primary auditory field (AI), secondary auditory field (AII), anterior auditory field (AAF), insular auditory field (IAF), ultrasonic field (UF) and dorsoposterior field (DP). Previous studies have examined thalamo-cortical connections in the mice auditory system and learned that AI, AAF, and IAF receive inputs from the ventral division of the medial geniculate body (MGB). However, the functional and thalamo-cortical connections between nonprimary auditory cortex (AII, UF, and DP) is unclear. In this study, we examined the locations of neurons projecting to these three cortical sub-fields in the MGB, and addressed the question whether these cortical sub-fields receive inputs from different subsets of MGB neurons or common. To examine the distributions of projecting neurons in the MGB, retrograde tracers were injected into the AII, UF, DP, after identifying these areas by the method of Optical Imaging. Our results indicated that neuron cells which in ventral part of dorsal MGB (MGd) and that of ventral MGB (MGv) projecting to UF and AII with less overlap. And DP only received neuron projecting from MGd. Interestingly, these three cortical areas received input from distinct part of MGd and MGv in an independent manner. Based on our foundings these three auditory cortical sub-fields in mice may independently process auditory information.
Quantitative assessment of the erosion and deposition effects of landslide-dam outburst flood, Eastern Himalaya
Authors: Dong Xiaolu , Wang Xianyan , Yang Long , Zhao Zhijun , Van Balen Ronald , Miao Xiaodong , Liu Tao , Vandenberghe Jef , Pan Baotian , Gibling Martin , Lu Huayu
Published: March 2024

Both regular flow and infrequent outburst floods shape the mountain landscape, but their relative contributions have been widely debated, in part due to the paucity of quantitative data on historical outburst floods. In June 2000, an outburst flood was triggered by a landslide-dam failure in a rapidly exhumed region of the Eastern Himalaya. To investigate the role of this kind outburst flood on landscape evolution, we employ topographic differencing, satellite imagery, and 2D hydraulic simulations to quantify the equivalent erosion and deposition within ~ 80 km flood route downstream of the breach. The flood lasted for ~ 10 h, with a peak discharge of 105 m3/s, leading to average erosion of 10 m, and contributed ~ 1–2 × 103 times more sediment than over long-term mean fluvial processes. The flood produced extensive lateral erosion, which triggered a threefold widening of the valley floor and abundant subsequent landslides. The ubiquitous boulder bars deposited in the channel inhibited incision, and facilitated lateral erosion after the flood. The resulting channel configuration and extensive bank erosion continue to affect fluvial dynamics until the next catastrophic flood that remobilizes the boulders. Our quantitative findings highlight the profound importance of recurrent outburst floods for gorge development and landscape evolution in Eastern Himalaya.
High allelic diversity in Arabidopsis NLRs is associated with distinct genomic features
Authors: Sutherland Chandler A , Prigozhin Daniil M , Monroe J Grey , Krasileva Ksenia V
Published: March 2024

Plants rely on Nucleotide-binding, Leucine-rich repeat Receptors (NLRs) for pathogen recognition. Highly variable NLRs (hvNLRs) show remarkable intraspecies diversity, while their low-variability paralogs (non-hvNLRs) are conserved between ecotypes. At a population level, hvNLRs provide new pathogen-recognition specificities, but the association between allelic diversity and genomic and epigenomic features has not been established. Our investigation of NLRs in Arabidopsis Col-0 has revealed that hvNLRs show higher expression, less gene body cytosine methylation, and closer proximity to transposable elements than non-hvNLRs. hvNLRs show elevated synonymous and nonsynonymous nucleotide diversity and are in chromatin states associated with an increased probability of mutation. Diversifying selection maintains variability at a subset of codons of hvNLRs, while purifying selection maintains conservation at non-hvNLRs. How these features are established and maintained, and whether they contribute to the observed diversity of hvNLRs is key to understanding the evolution of plant innate immune receptors.
A ratiometric upconversion nanoprobe enables super-resolution imaging sensing of biothiols in living cells
Authors: Chen Hongqi , Wang Ruoxin , Cheng Juanjuan , Wang Lun , He Hua
Published: March 2024

An upconversion luminescent ratiometric probe was developed for super-resolution imaging sensing of biothiols in living cells using single-particle localization and rendering method.
Discriminatory fluorescence and FRET in the chiral-perovskite/RhB system
Authors: Li Hongxu , Cui Ying , Tao Min , Sun Shuo , Yan Xinyao , Xiao Yin
Published: March 2024

We demonstrate that “chirality” cannot be transferred along with energy from chiral nanostructures to achiral molecules in a donor–acceptor system.
Challenges and opportunities on sustainable electrochemical transformations: application towards the synthesis of pharmaceuticals and precursors of drug-like molecules
Authors: Ghosh Adrija , Parida Vishal Kumar , Banerjee Debasis
Published: March 2024

This article highlighted the recent demand for sustainable and resource efficient drug synthesis using electrochemical strategies.
An encapsulation strategy to design an In-TS-1 zeolite enabling high activity and stability toward the efficient production of methyl lactate from fructose
Authors: Jiang Yuxi , Lyu Xilei , Chen Chao , Ren Aotian , Qin Wenqi , Chen Hao , Lu Xiuyang
Published: March 2024

Encapsulated In-TS-1 zeolite, demonstrating outstanding catalytic activity and stability, were effectively synthesized and utilized for the efficient one-pot conversion of fructose into methyl lactate (MLA).
Tailored design, synthesis, and catalytic aspects of mononuclear cis-dichloro copper(ii) complexes with simple DPA-derived tridentate ligands and their biomimicking activities
Authors: Muley Arabinda , Karumban Kalai Selvan , Kumbhakar Sadananda , Mathur Shobhit , Roy Indrajit , Verma Anushka , Kumawat Manoj Kumar , Maji Somnath
Published: March 2024

Two new mononuclear pentacoordinated square pyramidal Cu(ii) complexes with dipicolylamine-based tuned tridentate ligands have been prepared. Under aerobic conditions, o-aminophenol and catechol oxidation activities resulted in high turnover numbers.
Potassium-promoted Ru-MCM-41 catalyst via in situ loading for effective low-temperature ammonia decomposition
Authors: Yang Jingwei , Zhao Xiaodong , Qi Xun , Wen Jie , Zhang Hui
Published: March 2024

A potassium (K)-promoted Ru-based siliceous molecular sieve catalyst, K-nRu-MCM-41, was successfully synthesized via a hydrothermal method.
Synthetic urushiols from biorenewable carbon resources: chemical conversion of enzymatic degradation products of wood lignin to an ancient yet future coating material
Authors: Isozaki Katsuhiro , Matsuda Hiroshi , Agata Ryosuke , Jeon Jaeyoung , Wu Beiling , Pincella Francesca , Ikenaga Makoto , Tachibana Yoichi , Ohta Yukari , Nakamura Masaharu
Published: March 2024

An artificial urushi coating material was developed by chemical conversion of bio-renewable carbon resources, such as phenylpropanoids obtained from enzymatic degradation of woody lignin and vegetable fat.
In situ monitoring of the shikimate pathway: a combinatorial approach of Raman reverse stable isotope probing and hyperspectral imaging
Authors: Karlo Jiro , Gupta Aryan , Singh Surya Pratap
Published: March 2024

Sensing and visualization of metabolites and metabolic pathways in situ are significant requirements for tracking their spatiotemporal dynamics in a non-destructive manner.
Synthesis of two nitrogen-containing polyaromatic compounds through gold catalysis/DBU-promoted cyclizations
Authors: Sadaphal Vikas Ashokrao , Wu Tien-Lin , Liu Rai-Shung
Published: March 2024

This work reports novel gold catalysis and DBU-promoted cyclizations between 2-(2-ethynylaryl)acetonitriles and anthranils to construct benzo[7,8]indolizino[2,3,4,5-ija]quinazoline frameworks.
RNase H-dependent DNA thresholder modulated by cancer marker concentration
Authors: Nour Moustapha A. Y. , Drozd Valeriia S. , Lemeshko Evgenii A. , Tafran Lilia , Salimova Adeliia A. , Kulikova Alexandra V. , Eldeeb Ahmed A.
Published: March 2024

Threshold antisense oligonucleotide constructs were designed to cleave mRNA within different biomarker concentrations.
Excellent capture of N2O functioning at RT and lower pressure by utilizing an NaCaA-85 zeolite
Authors: Hiraki Suguru , Baba Haruka , Kobayashi Ikuka , Oda Akira , Ohkubo Takahiro , Ikemoto Yuka , Moriwaki Taro , Kuroda Yasushige
Published: March 2024

We have succeeded in trapping N2O efficiently and selectively even at 300 K and 0.3 Torr by utilizing CaA-type zeolite; the N2O molecule adsorbed is pinned by two kinds of Ca2+ ions exchanged in adjacent sites formed from 8- and 6-membered rings.
Construction of heterostructured Fe2O3/Fe7S8hollow fibers to boost the electrochemical kinetics of lithium storage
Authors: Liu Kaitao , Li Qiaoling , Song Yingying , Song Yifei , Yan Zhiming , Wang Junzhe , Li Xueda , Wang Hongqiang , Li Jiao
Published: March 2024

Benefitting from the synergistic effect of a hollow structure and a built-in electric field induced by the heterostructure, the as-prepared Fe2O3/Fe7S8composite anode exhibits excellent electrochemical performance.
Towards tailoring hydrophobic interaction with uranyl(vi) oxygen for C–H activation
Authors: Tsushima Satoru , Kretzschmar Jérôme , Doi Hideo , Okuwaki Koji , Kaneko Masashi , Mochizuki Yuji , Takao Koichiro
Published: March 2024

Hydrophobic interaction between uranyl(vi) and protein is the key to proteolysis.
Coral-mimetic production of aragonite films from CO2 captured by biogenic polyamines
Authors: Takashina Kohei , Watanabe Hiroto , Oaki Yuya , Ohno Yoshikazu , Yasumoto Ko , Imai Hiroaki
Published: March 2024

We designed CaCO3 films comprised of aragonite nanorods by mimicking the microstructure and the formation process of the calcareous skeleton of a stony coral in the sea.
Crystallization behaviour and growth mechanisms of spinel crystals in vanadium slag with high MgO content
Authors: Diao Jiang , Tao Haoran , Lai Zhiqiu , Qiu Yiyu , Chen Lian , Li Hongyi , Xie Bing
Published: March 2024

In this study, MgO content and FeO/SiO2 ratio were found to significantly increase the integrated crystallization rate of spinel phase in vanadium slag.
Terahertz electric field induced melting and transport of monolayer water confined in double-walled carbon nanotubes
Authors: Wu Yue , Wang Zi , Li Shuang , Su Jiaye
Published: March 2024

Monolayer ice confined in double-walled carbon nanotubes can be effectively melted using terahertz electric fields.
Iron-arsenide monolayers as an anode material for lithium-ion batteries: a first-principles study
Authors: Kumar Ajay , Parida Prakash
Published: March 2024

Schematic diagram of FeAs monolayer as an anode material for rechargeable Li-ion batteries.
A NiO-nanostructure-based electrochemical sensor functionalized with supramolecular structures for the ultra-sensitive detection of the endocrine disruptor bisphenol S in an aquatic environment
Authors: Hyder Ali , Ali Akbar , Buledi Jamil Ahmed , Memon Roomia , Al-Anzi Bader S. , Memon Ayaz Ali , Kazi Mohsin , Solangi Amber Rehana , Yang Jun , Thebo Khalid Hussain
Published: March 2024

A unique NiO-nanoparticle-based electrochemical sensor functionalized with a para-hexanitrocalix[6]arene derivative (p-HNC6/NiO) is developed for the determination of bisphenol S in real samples.
Theoretical insight into the rearrangement of sulfur atoms on the Ni- and Cu-doped MoS2 S-edge induced by hydrogen adsorption under HDS reaction conditions
Authors: Vidal Alba B. , Hurtado-Aular Oscar , Peña-Mena José Luis , Añez Rafael , Sierraalta Aníbal
Published: March 2024

Density functional theory (DFT) calculations and an atomistic thermodynamic approach were used to study the geometric rearrangement of sulfur atoms on the Ni- and Cu-doped MoS2 S-edge upon hydrogen adsorption.
Iron-doped cobalt phosphide nanowires prepared via one-step solvothermal phosphidization of metal–organic frameworks for the oxygen evolution reactions
Authors: Tong Jianbo , Xing Yichuang , Xiao Xuechun , Liu Yuan , Hu Zhikai , Wang Zeyi , Hu Yanling , Xin Bowen , Liu Shuling , Wang He , Wang Chao
Published: March 2024

A solvothermal phosphidization method is adopted to construct CoFeP nanowires to electrochemically catalyze oxygen evolution reaction.
Quantification capabilities of N2 MICAP-MS with solution nebulization and aerosol desolvation
Authors: Kuonen Monique , Hattendorf Bodo , Günther Detlef
Published: March 2024

The capabilities of an N2 MICAP-QMS were investigated for routine applications. The estimated plasma gas temperatures were similar to those of an Ar ICP.
A self-assembly and cellular migration based fabrication of high-density 3D tubular constructs of barrier forming membranes
Authors: Jalali Seyedaydin , Selvaganapathy Ponnambalam Ravi
Published: March 2024

A scalable method for creating perfusable 3D tissue constructs using self-assembly is introduced. Unlike conventional cell injection methods, here we leverage cell migration to form tissue barriers of low permeability, mimicking in vivo environments.
Pyrazolopyridine-based kinase inhibitors for anti-cancer targeted therapy
Authors: Halder Pallabi , Rai Anubhav , Talukdar Vishal , Das Parthasarathi , Lakkaniga Naga Rajiv
Published: March 2024

Pyrazolopyridines have gained increasing attention in kinase-targeting anti-cancer drug discovery. This review analyzes the success stories wherein this bicycle was employed to address various challenges.
Novel phosphate ester extractant for preferential extraction of hafnium over zirconium and its mechanism
Authors: Luo Yanping , Xu Chengjin , Su Jianhui , Peng Xiujing , Kong Xiangfeng , Wang Shuo , Sun Jiahui , Cui Yu , Nie Yong , Jiang Xuchuan , Sun Guoxin
Published: March 2024

The crystal of the Hf extracted species shows one Hf ion bound to six extractant molecules.
Direct evidence of time-dependent crystallization evolution of SAPO-34 and SAPO-20 zeolites directed by trimethylbenzylammonium hydroxide for microwave-assisted ethanolysis of furfuryl alcohol
Authors: Wang Guanchen , AlMasoud Najla , Alomar Taghrid S. , Azman Yasmin Nadhirah , Maireles-Torres Pedro , Chia Stephen , Juan Joon Ching , Ling Tau Chuan , El-Bahy Zeinhom M. , Ng Eng-Poh
Published: March 2024

Time-dependent crystallization evolution for synthesizing SAPO34 and SAPO-20 zeolites from a very active hydrogel is followed and reported where the XRD, FTIR, TGA/DTG, SEM/EDX, N2 adsorption–desorption and TPD-NH3 techniques are used.
Correction: Transition-metal-free glycosyl sulfonation of diaryliodonium salts with sodium glycosyl sulfinate: an efficient approach to access glycosyl aryl sulfones
Authors: Luo Jiaxin , Chen Xinyu , Ding Wenyan , Ma Jialu , Ni Zhaohui , Xie Lihuang , Xu Chunfa
Published: March 2024

Correction for ‘Transition-metal-free glycosyl sulfonation of diaryliodonium salts with sodium glycosyl sulfinate: an efficient approach to access glycosyl aryl sulfones’ by Jiaxin Luo et al., New J. Chem., 2024, 48, 4218–4223, https://doi.org/10.1039/D3NJ05942A.
Platform for 3-fluoro-3-hydroxyoxindoles: photocatalytic C–N cross-coupling and deaminative oxidation–fluorohydroxylation
Authors: Zhang Letian , Wang Yibin , Shen Jiabin , Xu Hao , Shen Chao
Published: March 2024

A photocatalytic C–N cross-coupling and deaminative fluorinating strategy has been developed to afford 3-fluoro-3-hydroxyoxindoles with wide functionality tolerance and good yields.
Recent advances in the fluorimetric and colorimetric detection of cobalt ions
Authors: Shahbaz Muhammad , Dar Birra , Sharif Shahzad , Khurshid Muhammad Aqib , Hussain Sajjad , Riaz Bilal , Musaffa Maryam , Khalid Hania , Ch Ayoub Rashid , Mahboob Abia
Published: March 2024

Cobalt is an essential metal to maintain several functions in the human body and is present in functional materials for numerous applications.
ADME profiling, molecular docking, DFT, and MEP analysis reveal cissamaline, cissamanine, and cissamdine from Cissampelos capensis L.f. as potential anti-Alzheimer's agents
Authors: Alhawarri Maram B. , Al-Thiabat Mohammad G. , Dubey Amit , Tufail Aisha , Fouad Dania , Alrimawi Bilal Harieth , Dayoob Mohamad
Published: March 2024

Proaporphine alkaloids—cissamaline, cissamanine, and cissamdine—show promise against AD, with in silico studies highlighting their potential as new therapeutics.
Expression of concern: Highly porous copper-supported magnetic nanocatalysts: made of volcanic pumice textured by cellulose and applied for the reduction of nitrobenzene derivatives
Authors: Taheri-Ledari Reza , Saeidirad Mahdi , Qazi Fateme Sadat , Fazeli Atefeh , Maleki Ali , Shalan Ahmed Esmail
Published: March 2024

Expression of concern for ‘Highly porous copper-supported magnetic nanocatalysts: made of volcanic pumice textured by cellulose and applied for the reduction of nitrobenzene derivatives’ by Reza Taheri-Ledari et al., RSC Adv., 2021, 11, 25284–25295, https://doi.org/10.1039/D1RA03538J.
Expression of concern: Impact of some pyrrolidinium ionic liquids on copper dissolution behavior in acidic environment: experimental, morphological and theoretical insights
Authors: El-Katori Emad E. , Abousalem Ashraf S.
Published: March 2024

Expression of concern for ‘Impact of some pyrrolidinium ionic liquids on copper dissolution behavior in acidic environment: experimental, morphological and theoretical insights’ by Emad E. El-Katori and Ashraf S. Abousalem, RSC Adv., 2019, 9, 20760–20777, https://doi.org/10.1039/C9RA03603B.
Future costs of hydrogen: a quantitative review
Authors: Frieden Florian , Leker Jens
Published: March 2024

A quantitative review of 89 hydrogen production cost forecasts, providing future prospects and multifaceted analyses.
Embedded 3D printing of RGO frameworks with mechanical strength, and electrical and electromagnetic interference shielding properties
Authors: Wang Yue , Luo Jialiang , Yang Cao , Xiao Lei , Hao Gazi , Wang Suwei , Jiang Wei
Published: March 2024

Micro-porous and micro-dense 3D RGO frameworks prepared by embedded 3D printing are reported, and the 3D RGO frameworks exhibit high electrical conductivity, high mechanical strength, and excellent electromagnetic interference shielding properties.
Psychedelics: reconnecting the brain to heal the mind
Authors: Nutt David J.
Published: March 2024

Natural psychedelics such as magic mushrooms have a long history of human use of at least 7000 years. Their use underwent a resurgence in the 1950/1960s following the synthesis of LSD as a psychedelic and its use as a medicine with powerful therapeutic benefits. But because non-medical use led to massive cultural changes especially in young people, all psychedelics were banned globally in the early 1970s. Over the past 20 years, there has been a resurrection of psychedelic research. This has revealed their common modes of action as agonists (stimulators) of the serotonin 5-HT2A receptor in the brain and that this activity leads to profound alterations in neuro-circuitry, producing a more integrated and flexible pattern of activity. These brain changes found in healthy volunteers predicted utility in mental illnesses such as depression and addiction and subsequent trials revealed this to be true. A single psychedelic trip can lead to very long-lasting improvements in a range of mental illnesses. From these remarkable and consistent positive outcomes, it seems likely that psychedelic therapy will soon become widely approved in western medicine, as it has already been in Australia for treatment-resistant depression.
Complex I activity in hypoxia: implications for oncometabolism
Authors: Chinopoulos Christos
Published: March 2024

Certain cancer cells within solid tumors experience hypoxia, rendering them incapable of oxidative phosphorylation (OXPHOS). Despite this oxygen deficiency, these cells exhibit biochemical pathway activity that relies on NAD+. This mini-review scrutinizes the persistent, residual Complex I activity that oxidizes NADH in the absence of oxygen as the electron acceptor. The resulting NAD+ assumes a pivotal role in fueling the α-ketoglutarate dehydrogenase complex, a critical component in the oxidative decarboxylation branch of glutaminolysis — a hallmark oncometabolic pathway. The proposition is that through glutamine catabolism, high-energy phosphate intermediates are produced via substrate-level phosphorylation in the mitochondrial matrix substantiated by succinyl-CoA ligase, partially compensating for an OXPHOS deficiency. These insights provide a rationale for exploring Complex I inhibitors in cancer treatment, even when OXPHOS functionality is already compromised.
Insights into the dynamics of the Ca2+ release-activated Ca2+ channel pore-forming complex Orai1
Authors: Fröhlich Maximilian , Söllner Julia , Derler Isabella
Published: March 2024

An important calcium (Ca2+) entry pathway into the cell is the Ca2+ release-activated Ca2+ (CRAC) channel, which controls a series of downstream signaling events such as gene transcription, secretion and proliferation. It is composed of a Ca2+ sensor in the endoplasmic reticulum (ER), the stromal interaction molecule (STIM), and the Ca2+ ion channel Orai in the plasma membrane (PM). Their activation is initiated by receptor-ligand binding at the PM, which triggers a signaling cascade within the cell that ultimately causes store depletion. The decrease in ER-luminal Ca2+ is sensed by STIM1, which undergoes structural rearrangements that lead to coupling with Orai1 and its activation. In this review, we highlight the current understanding of the Orai1 pore opening mechanism. In this context, we also point out the questions that remain unanswered and how these can be addressed by the currently emerging genetic code expansion (GCE) technology. GCE enables the incorporation of non-canonical amino acids with novel properties, such as light-sensitivity, and has the potential to provide novel insights into the structure/function relationship of CRAC channels at a single amino acid level in the living cell.
Scaffolds and the scaffolding domain: an alternative paradigm for caveolin-1 signaling
Authors: Lim John E. , Bernatchez Pascal , Nabi Ivan R.
Published: March 2024

Caveolin-1 (Cav1) is a 22 kDa intracellular protein that is the main protein constituent of bulb-shaped membrane invaginations known as caveolae. Cav1 can be also found in functional non-caveolar structures at the plasma membrane called scaffolds. Scaffolds were originally described as SDS-resistant oligomers composed of 10–15 Cav1 monomers observable as 8S complexes by sucrose velocity gradient centrifugation. Recently, cryoelectron microscopy (cryoEM) and super-resolution microscopy have shown that 8S complexes are interlocking structures composed of 11 Cav1 monomers each, which further assemble modularly to form higher-order scaffolds and caveolae. In addition, Cav1 can act as a critical signaling regulator capable of direct interactions with multiple client proteins, in particular, the endothelial nitric oxide (NO) synthase (eNOS), a role believed by many to be attributable to the highly conserved and versatile scaffolding domain (CSD). However, as the CSD is a hydrophobic domain located by cryoEM to the periphery of the 8S complex, it is predicted to be enmeshed in membrane lipids. This has led some to challenge its ability to interact directly with client proteins and argue that it impacts signaling only indirectly via local alteration of membrane lipids. Here, based on recent advances in our understanding of higher-order Cav1 structure formation, we discuss how the Cav1 CSD may function through both lipid and protein interaction and propose an alternate view in which structural modifications to Cav1 oligomers may impact exposure of the CSD to cytoplasmic client proteins, such as eNOS.
Stability Over Time of Word Syllable Duration for Speakers With Acquired Apraxia of Speech
Authors: Bunker Lisa D. , Bailey Dallin J. , Poss Elaine , Mauszycki Shannon , Wambaugh Julie L.
Published: March 2024

Purpose:

Neurogenic speech and language disorders—such as acquired apraxia of speech (AOS) and aphasia with phonemic paraphasia (APP)—are often misdiagnosed due to similarities in clinical presentation. Word syllable duration (WSD)—a measure of average syllable length in multisyllabic words—serves as a proxy for speech rate, which is an important and arguably more objective clinical characteristic of AOS and APP. This study reports stability of WSD over time for speakers with AOS (and aphasia).

Method:

Twenty-nine participants with AOS and aphasia (11 women and 18 men,
M
age
= 53.5 years,
SD
= 13.3) repeated 30 multisyllabic words (of three-, four-, and five-syllable lengths) on three occasions across 4 weeks. WSDs were calculated for each word and then averaged across each list (i.e., word length), as well as across combined lists (i.e., all 30 words) to yield four WSDs for each participant at each time point. Stability over time was calculated using Friedman's test for the group and using Spearman's rho for the individual level. Effects of time and word length were examined using robust mixed-effects linear regression.

Results:

Friedman's tests and correlations indicated no significant difference in WSDs across sampling occasions for each word length separately or combined. WSD correlated positively with AOS severity and negatively with intelligibility but was not correlated with aphasia severity. Regression analyses confirmed WSD to be stable over time, while WSD calculated from only five tokens (i.e., WSD-5) was less stable over time.

Conclusions:

Results indicate that WSD can be a stable measure over time, at the individual and group level, providing support for its use in diagnosis and/or as an outcome measure, both clinically and for research. In general, WSD outperformed WSD-5, suggesting that it may be better to calculate WSD from more than five tokens. Stability of WSD in other populations and suitability for differential diagnosis need to be determined. Currently, differentiating disorders by speaking rate, alone, is not recommended.

Supplemental Material:

https://doi.org/10.23641/asha.25438735
Nutritional content of Ficus benjamina fruits consumed by Frugivorous birds in Taman Botani Johor
Authors: Pa’ee Furzani , Saien Nur Faizah Azzahra Mohd , Norazlimi Nor Atiqah , Sulaiman Hairul Azhar
Published: March 2024

Ficus benjamina is a common tree in Taman Botani Johor and a food source for many frugivorous birds. This study investigated the nutrient content of F. benjamina fruits by analyzing the fruits of 7 species of birds that were observed safely feeding on the tree. The fruits were collected and analyzed for their nutrient content using a standard method for nutritional composition determination. The results showed that the fruits have a high carbohydrate content (19.7%), a low fat content (0.6%), and a moderate protein content (1.5%). The fruits also have a high moisture content (76.7%) and a low ash content (1.6%). The high carbohydrate content of fruits is likely attractive to frugivorous birds, as carbohydrates are an important energy source for reproduction, growth, and development. The low-fat content may also be beneficial to the birds, as excess fat can be harmful to their health. The results of this study provide valuable information on the nutrient content of F. benjamina fruits, which can be used to better understand the feeding ecology of frugivorous birds in Taman Botani Johor in a safe manner.
Growth of Catfish Clarias gariepinus (Burchell, 1822) under Different Rearing Methods and Feed Types
Authors: Nicholas Rahmanto Darren , Annisa Diva Pratiwi Adinda , Aufa Astagina Rahman Rr. Rahil , Nurhayati Nurhayati , Fitria Laksmindra
Published: March 2024

Inadequate protein intake results in stunting and wasting in children as well as cause health problems at all ages. Proteins from fish excel in promoting children's growth and family health. Consuming catfish has the potential to improve family nutrition because of its affordability, ease of being raised, and dense contents of proteins and beneficial fats. This study aimed to compare the growth of catfish raised in concrete ponds and buckets and also to compare catfish fed with probiotic-fortified and regular feeds. The concrete pond was stocked with 300 juveniles, whereas 80 juveniles each were placed in two buckets. The experiment lasted for 12 weeks. Probiotic feed was given twice a day. After six weeks, probiotic feed in one of the buckets was replaced with regular feed. Body length and weight were assessed once per week with 10-20 % samples of the population. Data were analyzed statistically with two-way ANOVA and post hoc Duncan (α=0.05). Catfish raised in buckets can grow similarly to ones reared in concrete ponds with a suitable ratio of fish to water volume and proper care. Probiotic feed increased catfish growth rate. However, there was no significant difference after replacing probiotic feed with regular feed.