bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental and simulation study on a rooftop vertical-axis wind turbine
Authors: Ali Malek , Gherissi Abderraouf , Altaharwah Yousef
Published: June 2023

In this study, a small vertical-axis wind turbine (VAWT) was successfully designed and tested to produce electrical energy using renewable wind energy after being installed on the roof of buildings. The VAWT was constructed according to the existing wind source in the Tabuk region in Saudi Arabia. The use of VAWT on roofs is a sustainable solution for producing clean electricity and contributing to a portion of the local electricity consumption. A rooftop wind turbine test was performed to determine the behavior and output of a VAWT under non-constant wind speeds under natural conditions. To verify the resistance of the shear stress and pressure, a computational fluid dynamics (CFD) simulation on the airfoil was conducted. The experimental test results showed that the VAWT can reach its rated power at 9 m/s. The minimum wind speed needed for power production was 3 m/s. The maximum power coefficient obtained during testing was approximately 0.45 at a tip speed ratio of around 1.94. The simulation mesh is constructed with Ansys mesh. Two dimensional (2-D) mapped face meshing, fine, high smoothing mesh was constructed with 50 division numbers and a bias factor of about 150. The grid with 15,000 cells generated the same results as the higher number of cell grids. The simulation equivalent force was about 2.8 N for a single blade, such as 8.5 N in total, which presents an error of about 3%. The CFD simulation and experimental tests on existing forces confirm that the VAWT structure’s resistance can be guaranteed at high wind speeds.
Qiao-Yi-Phänomen der chinesischen Legende

Weiße Schlange in der deutschen Literatur
Authors: Duan Yanan , Zhang Fan
Published: June 2023

Die Legende Weiße Schlange zählt zu den vier berühmtesten Legenden des chinesischen Altertums, die im chinesischen Volksmund seit mehr als tausend Jahren tradiert sowie literarisch gestaltet wurden und daher bis heute lebendig sind. Dieser Beitrag gibt einen Überblick über ihre Verbreitung und Variation in Deutschland in den letzten zwei Jahrhunderten. Dabei wird das Qiao-Yi-Phänomen besonders in den beiden deutschen Versionen, Die Schlange von Herman Grimm und Im Zauber der weißen Schlange von Helmut Matt, im Vergleich mit der chinesischen Originallegende analysiert. Darüber hinaus wird einerseits die dualistische Interaktion der Legende Weiße Schlange zwischen China und Deutschland in der Literatur aus der Perspektive der Qiao-Yiologie aufgezeigt und andererseits werden die dahinterstehenden sozio-historischen Gründe für das Qiao-Yi-Phänomen und die Motive der Autoren näher erforscht.
“You have to strive very hard to prove yourself”: experiences of Black nursing students in a Western Canadian province
Authors: Luhanga Florence , Maposa Sithokozile , Puplampu Vivian , Abudu Eunice , Chigbogu Irene
Published: June 2023

Objectives

This study explored the experiences of Black students in two western Canadian undergraduate nursing programs.

Methods

Using a qualitative focused ethnography design grounded in critical race theory and intersectionality, participants were recruited using purposive and snowball sampling. Data were collected through individual interviews, and a follow-up focus group. Data were analyzed using collaborative-thematic analysis team approaches.

Results

n=18 current and former students participated. Five themes emerged: systemic racism in nursing, precarious immigrant context, mental health/well-being concerns, coping mechanisms, and suggestions for improvement.

Conclusions

An improved understanding of Black student experiences can inform their recruitment and retention. Supporting Black students’ success can potentially improve equity, diversity, and inclusivity in nursing education programs and/or their representation in the Canadian nursing workforce.

Implications for an international audience

The presence of a diverse nursing profession is imperative to meet the needs to provide more quality and culturally competent services to diverse population.
The Poetry of Ordinary Language
Authors: Verge Patrick
Published: June 2023

The general argument of this essay is that poetry is an everyday ambition and an everyday accomplishment. The evidence for this – a good bit of which I will amass enthusiastically in what follows – is everywhere in our language. I explore this according to three guiding intuitions: (i) people, at least some of the time, want to give their words a similar intensity or fullness and show the same skill in unleashing verbal power, as poets do – seeking words that will carry their voices; (ii) people say things give me the same aesthetic bliss and ache of gratitude that poetry gives me; and (iii) there seems to be a poetic or aesthetic dimension to all of language, without which words would not have the significance for us that they do. I end the essay by saying why the poetry in our everyday speech complicates the relation between the ordinary and (different versions of) the extraordinary as other philosophers have imagined it.
Optimizing curing agent ratios for high-performance thermosetting phthalonitrile-based glass fibers
Authors: Lee Joon Hyuk , Jeon Eunkyung , Song Jung-kun , Son Yujin , Choi Jaeho
Published: June 2023

Phthalonitrile (PN) is a highly promising material in the field of high-performance thermosetting polymers due to its ability to maintain its properties even at extremely high temperatures. The goal of this study was to investigate the effects of varying curing agents on the thermal properties of cured PN resin. The curing agents were found to effectively cure the resin, as indicated by the increasing ratio of N and S contents and decreasing the C content as the proportion of curing agents increased, as observed by scanning electron microscopy and energy dispersive X-ray spectroscopy data analyses. Moreover, thermogravimetric analyses revealed that the sample with 20% curing agent showed the highest thermal decomposition rate among the 2, 5, 10, and 20% curing agent dosages. These properties can be further improved by incorporating glass fibers. Overall, these results demonstrate the successful use of curing agents to create an efficient and functional polymer with superior thermal properties that are suitable for use in harsh environments. The findings of this study are a significant step forward in advancing the use of PN as a high-performance thermosetting polymer.
The intonation of neighboring varieties
Authors: Cataldo Violetta , Crocco Claudia
Published: June 2023

Despite the presence of several cross-variety studies on spoken varieties of regional Italian, research on the intonational transition across geographically close varieties is still scarce. This article tackles this issue by providing a first cross-variety comparison of question intonation in three neighboring varieties of Italian spoken in Campania, namely Neapolitan, Salerno and Cilento Italian. The three varieties are chosen based on their position with respect to the isoglosses identifying the Eboli-Lucera line. Such comparison is made possible using the methodological protocol outlined by Gili Fivela et al. (2015) and specifically concerns yes-no, wh- and disjunctive questions. This explorative study aims at identifying intonational features differenced by frequency of occurrence across space, thereby providing a basis for further quantitative studies on spatial distribution. Based on a corpus elicited with a combination of Discourse Completion Task and reading task, we analyze the phonological features of question tunes in Cilento Italian, while also comparing them to their counterparts in Neapolitan and Salerno Italian. Results show that the three varieties present systemic, realizational and phonotactic differences as well as differences in the frequency of occurrence of tonal events. The intraregional variation across Campania Italian varieties hints at an intonational transition featuring a smooth geographic cline.
SCREENING THE ALKALI-NEUTRALIZED SUNFLOWER SEED OIL BLEACHING ABILITY OF SOME NATURAL AND ACID-ACTIVATED NATURAL CLAYS, SYNTHETIC ADSORBENTS, AND METAL-ORGANIC FRAMEWORKS
Authors: YILMAZ Emin , YÜCETEPE Elif
Published: June 2023

The aim of this study was to search vegetable oil bleaching abilities of 30 different adsorbent materials placed into four groups (natural clay, acid-activated natural clay, synthetic adsorbent, metal-organic frames). After oil treatment against control sample, oil color (L, a*, b* values), oil weight loss (%), free fatty acidity (FFA), peroxide value (PV), and the specific extinctions of K232 and K270 were measured. Based on the data analysis, natural montmorillonite, acid-activated halloysite, Dowex, and Ti-MOF were selected, and tested in the same way against two commercial bleaching earth (C.B.E.) samples. Finally, an equal weight portion mixture of the four selected adsorbents were prepared and tested against C.B.Es. Results indicated that acid activated halloysite and Dowex had certain potentials to be implemented in oil bleaching. In conclusion, some other clay modification techniques suggested being applied to those potential adsorbents to improve their bleaching activity for potential commercial applications.
Nasal oxytocin administration does not influence eye gaze or perceived relationship of male volunteers with physicians in a simulated online consultation: a randomized, placebo-controlled trial
Authors: Jongerius Chiara , Hillen Marij A , Smets Ellen M A , Mol Mathijs J , Kooij Eefje S , de Nood Maria A , Dalmaijer Edwin S , Fliers Eric , Romijn Johannes A , Quintana Daniel S
Published: June 2023

The patient–physician relationship is a critical determinant of patient health outcomes. Verbal and non-verbal communication, such as eye gaze, are vital aspects of this bond. Neurobiological studies indicate that oxytocin may serve as a link between increased eye gaze and social bonding. Therefore, oxytocin signaling could serve as a key factor influencing eye gaze as well as the patient–physician relationship. We aimed to test the effects of oxytocin on gaze to the eyes of the physician and the patient–physician relationship by conducting a randomized placebo-controlled crossover trial in healthy volunteers with intranasally administered oxytocin (with a previously effective single dose of 24 IU, EudraCT number 2018-004081-34). The eye gaze of 68 male volunteers was studied using eye tracking during a simulated video call consultation with a physician, who provided information about vaccination against the human papillomavirus. Relationship outcomes, including trust, satisfaction, and perceived physician communication style, were measured using questionnaires and corrected for possible confounds (social anxiety and attachment orientation). Additional secondary outcome measures for the effect of oxytocin were recall of information and pupil diameter and exploratory outcomes included mood and anxiety measures. Oxytocin did not affect the eye-tracking parameters of volunteers’ gaze toward the eyes of the physician. Moreover, oxytocin did not affect the parameters of bonding between volunteers and the physician nor other secondary and exploratory outcomes in this setting. Bayesian hypothesis testing provided evidence for the absence of effects. These results contradict the notion that oxytocin affects eye gaze patterns or bonding.
A case of novel mutation in ANOS1 (KAL1) gene and review of Kallmann syndrome
Authors: Arora Sumeet , Yeliosof Olga , Chin Vivian L
Published: June 2023

Kallmann syndrome (KS) is a genetically heterogeneous condition characterized by hypogonadotropic hypogonadism with coexisting anosmia or hyposmia along with potential other phenotypic abnormalities depending on the specific genetic mutation involved. Several genetic mutations have been described to cause KS. The ANOS1 (KAL1) gene is responsible for 8% of mutations causing KS. A 17-year-old male presented to our clinic with delayed puberty and hyposmia, along with a family history suggestive of hypogonadism in his maternal uncle. Genetic testing for KS revealed complete exon 3 deletion in the ANOS1 gene. To the best of our knowledge, this specific mutation has not been previously described in the literature.

Learning points

Missense and frameshift mutations in the KAL1 or ANOS1 gene located in the X chromosome are responsible for 8% of all known genetic mutations of Kallmann syndrome.

Exon 3 deletion is one of the ANOS1 gene is a novel mutation, not reported before.

Targeted gene sequencing for hypogonadotropic hypogonadism can be employed based on the phenotypic presentation.
Optimal threshold for static 99R
Authors: Chang YingYin , Rekab Kamel , Yaghoub Majid Bani , Mueller Matthew
Published: June 2023

The Static 99R is an actuarial instrument that is widely used to assess the sexual recidivism risk of sex offenders. It is frequently applied in jurisdictions as a decision-making tool for release or indefinite admission to a psychiatric hospital within the jail of sex offenders. The decision to release or retain a criminal depends solely on the total score which is considered as the only independent variable. In our study, two models of Static 99R are considered: the 5-year high risk model and the 10-year high risk model. To identify the most appropriate threshold, we performed four independent methods. These are: the point closest-to-(0,1), the concordance probability (CZ), the index of union (IU), and the plot of sensitivity versus specificity. Remarkably, all four methods yielded identical results. For the 5-year high risk model, the optimal threshold is 0.184, which corresponds to a cut-off score of 5. Consequently, a score of 5 or higher implies that the offender is very likely to recidivate. Similarly, for the 10-year high risk, the optimal threshold is 0.293 which corresponds also to a cut-off score of 5.
Game of checkers: Ethnography of transvestites (travestis) who prostitute in Aracaju, capital of Sergipe/Brazil
Authors: dos Anjos Neto João Dantas
Published: June 2023

This research record is part of the cycle of an ethnographic investigation, which I carried out from 2014 to 2020, in territories of transvestite (travesti, in Portuguese) prostitution. The ethnography that moved along these years encompassed several cities, including European cities. However, I selected only part of the records made in Aracaju for this present contribution. The clipping is due to the urgency of exposing the conditions in which travestis, a silenced, concealed, stigmatized and violated group, submit themselves, as a Brazilian cultural phenomenon, when they find themselves at the heart of the tangled tensions in the field of forces that sew their nocturnal lives in regions of prostitution. Travestis are, in general terms, people designated male at birth, whose gender expression deviates from what is imposed on them and aligns with what is socially established as female. However, they do not consider themselves women.
A Note on Conservative Mixing: Implications for Selecting Salinity-Transport Model Constituents in the San Francisco Estuary
Authors:   Tetra Tech, Inc., Hutton Paul , Roy Sujoy ,   Tetra Tech, Inc.
Published: June 2023

The deviation of specific electrical conductance (EC) from conservative mixing behavior is well-established in the scientific literature. This principle is based on the observation that, as salt concentration in a water sample increases, the mobility of individual ions in the sample decreases, and thus their ability to conduct electricity decreases. Despite this fact, some commonly used models for salinity transport in the San Francisco Estuary (estuary) utilize EC as a primary simulation constituent, treating it as a conservative quantity. Such a modeling approach has likely been followed to exploit the wide availability of EC data for model calibration and validation, and to obviate the need to translate between EC and salinity in a domain characterized by multiple source waters with varying ionic make-ups. Arguably, this approach provides a reasonable trade-off between data translation error and model simulation error. In this paper, we critically evaluate this approach, employing an extensive salinity data set that includes measurements of EC and major ion concentrations in the estuary. We demonstrate and quantify EC deviation from steady-state, conservative mixing behavior; review the conservative mixing behavior of three bulk salinity measures (practical salinity, ionic strength, and limiting equivalent conductance); and evaluate their source-dependent correlations with EC in the estuary. We find limiting equivalent conductance—a value that assumes uninhibited mobility among individual ions in a water sample—to be an attractive alternative for salinity transport in the estuary. In addition to being a conservative quantity, it is consistently correlated with EC in the estuary’s dominant source waters, and thus addresses concerns related to data-translation error. We conclude this paper discussing pros and cons of adopting various salinity-transport model constituents.
Geochemistry and zircon U-Pb geochronology of the Dak Krong plutonic rocks in the Kontum Massif (central Vietnam) and their petrogenetic implications
Authors: Nguyen Kim Hoang , Nong Thi Quynh Anh , Pham Minh , Pham Trung Hieu , Nguyen Thanh Thao
Published: June 2023

Dak Krong plutonic rocks are found in the Kontum Massif along the N-S-oriented Po Ko River and mainly within the distributive area of the Ben Giang-Que Son granitic bodies. The Hai Van complex crosscuts the Dak-Krong rocks. They are predominantly composed of plagioclase (35-47%), quartz (29-30%), K-feldspar (20-28%), and minor biotite (3-4%). Geochemically, they are characterized by meta- to peraluminous and high-K affinities and straddle I- and S-type granite fields. Zircon U-Pb dating results yielded two main magmatic stages (ca. 258 Ma and ca. 245 Ma) spanning two phases of magmatism presumably accepted as being associated with the Paleo-Tethys Ocean evolution: latest subduction to syn-collisional phases. The Hf isotope data from zircon with eHf(t) ranging between -6.4 and -0.5 indicates a crustal signature. From the results of eHf(t) values along with zircon Hf model ages (TDM2) ranging from 1165-1497 Ma, it is presumable that the Dak Krong plutonic rocks are the product of the partial melting of Mesoproterozoic crustal materials with a negligible contribution of mantle materials. Together with other Permian-Triassic magmatic complexes throughout the Kontum Massif (e.g., Ben Giang-Que Son, Hai Van, and Van Canh complexes) and other plutonic further to the north along the Truong Son Belt and the Song Ma suture zone, the Dak Krong plutonic rocks represent magmatism generated by the amalgamation of Indochina and South China during the Late Permian-Early Triassic, referred to as Indosinian orogeny.
Tarekat and Politics in Indonesia: Contested Authority between Murshids in the Tarekat Qadiriyah wa Naqsyabandiyah in East Java
Authors: Zamzami Mukhammad , Mahzumi Fikri , A'la Abd
Published: June 2023

This article scrutinizes the dynamics between tarekat and politics in contemporary Indonesia in relation to the contested authority between murshids in the Tarekat Qadiriyah wa Naqsyabandiyah (TQN) in East Java. Using a historical approach, this article analyzes the position, characteristics, and political attitudes of the murshid in Jombang and Surabaya amidst the political currents during the New Order era. This article finds that murshids show adaptation and innovation in responding to challenges in their tarekat hierarchy and political leadership in Indonesia. The political stance of the murshid is considered a rational choice. In East Java, some murshids such as KH. Musta‘in Romli, KH. Adlan Ali, and KH. Usman al-Ishaqi developed different relationships with political organizations. Kiai Musta‘in tried to be adaptive and compromising as he involved in practical politics and joining the ruling party, i.e., Golkar. Kiai Adlan, on the contrary, kept his distance from the ruling regime by joining the Islamic United Development Party (Partai Persatuan Pembangunan/PPP). Kiai Usman, on the other side, remained loyal to the tarekat spirit as he refused to be involved in politics. The difference in political attitudes among the members of TQN has been considered a reflection of the political ijtihād of the murshids. Competition for authority, which resulted in conflict and internal divisions in this tarekat, is a logical consequence of political interests when they meet the tarekat and influence its dynamics.
Features of changes in the expression level of TNFα receptors and the functional response of cell lines upon stimulation with various doses of cytokine
Authors: Lopatnikova Yu. A. , Zhukova Yu. V. , Alshevskaya A. A. , Obleukhova I. A. , Kireev F. D. , Belomestnova I. A. , Sennikov S. V.
Published: June 2023

TNFa is a pro-inflammatory cytokine that is signaled through type 1 (TNFR1) and type 2 (TNFR2) receptors. TNFR1 normally mediates apoptosis, cell survival, and cytokine secretion, while TNFR2 selectively mediates cell survival and cytokine secretion. But in some cases, when receptors are activated, the functional response of cells changes to the opposite. Activation of signaling pathways has its own triggers, which differ in the interaction between different forms of cytokine and different forms of receptor complexes, as well as changes in the ratio of different types of receptors. The study of the mechanisms of regulation in the ligand-receptor system is a priority task for many studies. This work shows the dose-dependent effect of TNFa on the expression of cytokine receptors and changes in the functional response of tumor cell lines of various origins. For this, a comparative assessment of the expression and co-expression of receptors, cell cycle phases and apoptosis of cell lines without stimulation and stimulated with TNFa at concentrations of 5 and 50 ng/mL was carried out. It was found that the K562 cell line was characterized by more pronounced changes in receptor co-expression, which were observed at a TNFa concentration of 50 ng/mL compared to both the control group and the 5 ng/mL group. The decrease in the relative content of cells expressing only TNFR1 was combined with a decrease in the percentage of cells in apoptosis, which confirms the literature data on the role of this receptor in the development of apoptosis. At the same time, no changes in expression density were observed for this cell line. For the ZR75-1 cell line, the largest number of effects was also found for a TNFa concentration of 50 ng/mL. An increase in the relative content of cells expressing only TNFR2 was combined with an increase in apoptosis; however, the expression density of this type of receptor was low, which could affect the switching of signaling pathways towards proapoptotic ones. Thus, our study allowed us to reveal the features of changes in the expression and co-expression of TNFa receptors characteristic of cell lines of various origins, as well as changes in the functional response of cells in response to stimulation with different doses of cytokine. All this allows us to expand our understanding of the regulatory mechanisms in the cytokine-receptor system.
Cyberbullying and Motivation to Learn with Digital Technologies: Identification and Correlation
Authors: Beluce Andrea Carvalho , Oliveira Katya Luciane de , Ferraz Adriana Satico , Almeida Leandro da Silva
Published: June 2023

Abstract This article investigates the relationship of cyberbullying to motivation to learn and the use of digital information and communication technologies (DTIC). The survey included 529 high school and 293 higher education students who answered the Motivation to Learn Scale with the use of DITC Scale and the Cyberbullying Assessment Scale. Statistically significant correlations were identified between the constructs, especially in high school. The relationships had a positive direction, weak and high magnitude. Cyberbullying and educational levels predicted controlled (28%) and autonomous (5%) motivation. Motivation and cyberbullying levels stood out in high school. This research contributes to pedagogical practices and the conduct of further studies on this theme.
The Development of Psychological Assessment in Brazil and Current and Future Challenges
Authors: Noronha Ana Paula Porto , Reppold Caroline Tozzi , Bandeira Denise Ruchel , Santos Acacia A. A. dos
Published: June 2023

Abstract Brazilian psychological assessment possesses several indicators that prove its quality, although by the early 1990s, the use of psychological tests in evaluative processes had fallen into disrepute in society. The present article recounts the history of Brazilian psychological assessment, told through the lens of the creation of a working group (WG) of the Associação Nacional de Pesquisa e Pós-graduação em Psicologia (ANPEPP, National Association for Research and Graduate Studies in Psychology) and its subsequent achievements. The construction of the Sistema de Avaliação dos Testes Psicológicos (SATEPSI, Psychological Testing Assessment System) and its deployment, collectively, by the profession’s regulating agency with the collaboration of scientific associations as well as of the WG and ANPEPP are also mentioned. Many initiatives were reunited, rehabilitating the credibility of the practice of assessment. The authors stress the advances that still need to be made, such as widening research with minority groups and including new statistical analyses and technologies that will impact the development of psychological assessment.
INVESTIGATIONS ON OPEN-CELL METAL FOAM–FITTED TUBES FOR HEAT TRANSFER ENHANCEMENT – A DISCUSSION ON ENHANCEMENT MECHANISMS
Authors: Dhavale Aniket A. , Lele Mandar M.
Published: June 2023

Metal foams are drawing increasing attention due to their high surface area-to-volume ratio, high thermal conductivity, and low density. Heat exchanger manufacturers are constantly looking for innovative methods toward building highly efficient and compact heat exchangers. To enhance heat transfer, the effective thermal conductivity, fitment of foam on pipe, influence of working fluids, and effect of the bonding method are major areas of investigation. This paper aims to present a review of various investigations conducted on open-cell metal foam for enhancing heat transfer. The pore size distribution of metal foam directly influences the effective thermal conductivity. Recent progress toward bimodal pore size distribution has been reviewed and discussed. There exists a tradeoff between enhancing heat transfer and the corresponding pressure drop. Different configurations of fitting metal foam on pipes, such as fully filled, partially filled, and tubes wrapped with metal foam, are critically reviewed, and their performance is compared. The working fluid and its conditions used with metal foam has tremendous potential toward enhancing heat transfer. The influence of nonrefrigerants, refrigerants, and nanofluids has been presented in this regard. Different bonding methods and their influence on thermal resistance are also reviewed. To date, there is hardly any literature that addresses the performance of metal foam–fitted tubes in condensers and evaporators for vapor compression refrigeration systems. Metal foam-fitted tubes have shown promising results in terms of heat transfer enhancement. The outcome of this review provides insights into further research on the use of metal foam–fitted tubes for refrigeration applications.
Create Mask for Axonal Quantification Analysis with FIJI v1
Authors: Moreno Ramos Oscar
Published: June 2023

This is a protocol describing how to create a quantified mask from an image of fluorescence-tagged axonal projections using FIJI/ImageJ software.
Tail suspension test to assess depression/anxiety behavior in parkinsonian mice v1
Authors: not provided natalia.lopezgonzalezdelrey
Published: June 2023

The Tail Suspension Test is a mouse behavioral paradigm measuring behavioral despair or “depression-like” behavior and learned helplessness.
Making CFM v1
Authors: Brimblecombe Katherine
Published: June 2023

TBD
Western Blot v1
Authors: Brimblecombe Katherine
Published: June 2023

TBD
Hipertansiyon Rozasea Hastaları İçin Risk Mi?
Authors: ÖZTÜRK Ünal , ÖZTÜRK Savaş , ÇEÇEN Emin
Published: June 2023

Amaç: Rozasea genetik ve çevresel faktörlerin etkisiyle özellikle yüzün orta bölgesinde gelişen, yaygın, kronik enflamatuvar bir dermatozdur. Kronik enflamasyonun
hipertansiyon başta olmak üzere kardiyovasküler hastalıkların gelişimindeki rolü bilinmektedir. Bu çalışmada rozasea hastalarında hipertansiyon
araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Çalışmaya 73 rozasea hastası ve 70 gönüllü dâhil edildi. Rozasea ve kontrol grubundaki hastaların demografik özellikleri, özgeçmiş
bilgileri ve eşlik eden hastalıkları kayıt altına alındı. Rozasea tanısı için Amerikan Ulusal Rozasea Derneği tarafından geliştirilen, tanı koyma ve araştırmalar
sırasında kullanılabilen standart sınıflama kullanıldı. Çalışma grubunun dermatolojik muayeneleri sırasında ve muayeneden 2 hafta sonra tansiyonları
ölçüldü ve ortalama değerler not edildi.
Bulgular: Çalışmaya katılan 73 rozasea hastasından 17’si (%23.2) ve kontrol grubunu oluşturan 70 hastadan 12’si (%17.1) daha önceden hipertansiyon
(HT) tanısı ile takip edilen hastalardan oluşmaktaydı. Tanı konmuş HT sıklığı hasta grubunda kontrol grubuna göre istatistiksel olarak daha yüksek olarak
saptandı. Hasta ve kontrol grubunun ölçülen ortalama kan basınçları arasında ise istatistiksel fark bulunmadı.
Sonuç: Bu çalışmada elde ettiğimiz rozasea hasta grubunda yüksek HT sıklığı literatürlü uyumlu idi. Kronik enflamasyonla seyreden dermatolojik hastalıklarda
kardiyovasküler komorbiditelerin klinisyen tarafından göz önünde bulundurulması gereken bir durum olduğunu düşünmekteyiz.unu düşünmekteyiz.
Counterrevolution and Revolt, fifty years later. Kant, Marx, and the relevance of Herbert Marcuse’s aesthetic dimension
Authors: Ferreira de Souza Juliano Bonamigo
Published: June 2023

Recently, Critical Theory has been revisited due to the relevance of its critique of contemporary forms of alienation. This critique allows the unveiling of structural elements of contemporary ways of life, offering an accurate analysis of the material and subjective causes of the current environmental crisis. An example of this contribution is Herbert Marcuse’s book Counterrevolution and Revolt, published in 1972. This article addresses the relationship between aesthetics and political ecology established in the main theses of Marcuse’s book. The objective is to present how Marcuse employs the German philosophical tradition, more specifically elements of Kant’s Critique of the Power of Judgment and Marx’s Economic and Philosophical Manuscripts, to constitute a conceptual project of emancipation based on what he calls the aesthetic dimension. The article concludes by claiming that Marcuse’s critics and formulation entail a double requirement in which the field of Aesthetics has a central role.
Antiproliferative and Anti-Tyrosinase Activities of Propolis from Tetragonula laeviceps and Tetragonula pegdeni in Thailand
Authors: Meemongkolkiat Thitipan , Puthong Songchan , Khongkarat Phanthiwa , Rod-im Preecha , Duangphakdee Orawan , Phuwapraisirisan Preecha , Chanchao Chanpen
Published: June 2023

Propolis is one of the economic bee products with biological activities, but these activities can vary according to the local plants and bee species. This study aimed to evaluate the cytotoxic and antityrosinase activity of the methanol-, hexane-, and dichloromethane-partitioned propolis extracts (MPE, HPE, and DPE, respectively) of two dominant stingless bee species in Thailand (Tetragonula laeviceps and Tetragonula pegdeni) sourced from four locations in Ratchaburi province and one location in Chiangmai province. Their antiproliferative/cytotoxic activity, as the relative cell viability, was screened against the liver (Hep-G2) and gastric carcinoma (KATO-III) cancer cell lines in comparison to the untransformed lung fibroblast (WI-38) cell line using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Interestingly, DPE7 was the extract that showed great potential anticancer properties because it was significantly higher cytotoxic to cancer cell lines (Hep-G2 and KATO-III, with IC50 values of 36.40 and 35.15 mg/mL, respectively) than to normal cell lines (WI-38, with IC50 values of 46.52 mg/mL). Although DPE7 did not exhibit the highest antityrosinase activity, its moderate antityrosinase activity (IC50 of 1.388 mg/mL) considered it possible for further purification though not as effective as Kojic acid (IC50 of 0.0432 mg/mL). Besides, the different bioactivities in propolis from different sites were expected due to the different flora in each location. However, further studies are needed to better understand the properties and safety aspects of selected partitioned extracts.
Molecular Docking Analysis on the Designed Benzimidazole Derivatives as EGFR Inhibitors: Comparison between EGFR Wild-Type (EGFRWT) and T790M Mutant
Authors: Jalil Nurul Awani Syazzira , Abd Hamid Shafida
Published: June 2023

The non-small cell lung (NSCL) and colorectal cancers are frequently linked with the oncogenic activation of the epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinase (RTK) family. Current tyrosine kinase inhibitors (TKIs) are susceptible to drug resistance mutations and induce cytotoxicity effects on normal EGFRs. The isosteric nature of benzimidazole with purine renders its great potential to imitate the binding mode of the purine-based ATP and prevents its contact with the EGFR active sites. Here, we report the molecular docking of 50 designed benzimidazole derivatives, as well as Gefitinib and ATP, to analyse and compare their binding modes at EGFRwt and T790M active sites. The design of the ligands is based on our previous study, in which we proposed to evaluate keto- and amino-benzimidazoles, attached to a double bond linker and a phenyl group having electron donating and electron withdrawing groups attached at various positions. Docking simulations showed that keto-benzimidazoles dominated the top ten highest binding affinities in both EGFR-ligand complexes. The presence of sulfonyl substituents contributed to more stable complexes compared to others with binding energies of -8.1 (7c) and -7.8 (11c) kcal/mol in EGFRwt, and -8.3 (7d) and -8.4 (1c) kcal/mol for T790M mutant. The substituent effects on the benzimidazole contributed not only to the hydrogen bonding and hydrophobic interaction, but also to the often-disregarded Van der Waals forces that are responsible for shape complementarity of the benzimidazoles with the EGFR binding pocket.
Optimization of Tween 80 and PEG-400 Concentration in Indonesian Virgin Coconut Oil Nanoemulsion as Antibacterial against Staphylococcus aureus
Authors: Miksusanti Miksusanti , Elsa Fitria Apriani Elsa Fitria Apriani , Bama Bihurinin Azzahra Hiththah
Published: June 2023

Virgin Coconut Oil (VCO) can act as an antibacterial due to free fatty acids. To increase the stability of VCO, the VCO can be formed into nanoemulsion preparations. This study aimed to optimize the concentration of Tween 80 and Polyethylene glycol-400 (PEG-400) in nanoemulsion formula and determine antibacterial activity against Staphylococcus aureus. The content of VCO was determined using Gas Chromatography-Mass Spectrometry (GC-MS), and the results showed that VCO contained lauric acid, palmitic acid, caprylic acid, oleic acid, capric acid, and stearic acid. Optimization was carried out using the 22 factorial design method on the response of pH, density, percent transmittance, particle size, and polydispersity index. The optimum formula was obtained at concentrations of Tween 80 and PEG-400 40% and 26%, respectively, with a desirability value of 0.961. The optimum formula showed no phase separation and a significant decrease in pH (p>0.05). The optimum and comparison formula (pure VCO) had significantly different antibacterial activity (p<0.05) where the diameter of the inhibition zone was 24.77±1.66 mm and 16.73±2.00 mm, Minimum Inhibitory Concentration (MIC) of 1250 ppm and 2500 ppm, Minimum Bactericidal Concentration (MBC) of 2500 ppm and more than 2500 ppm, respectively. The optimum formula of VCO nanoemulsion was proven to have good stability and a potent antibacterial activity.
Kesan Suhu Pensinteran terhadap Mikrostruktur dan Sifat Mekanikal Perovskit Seramik SrFe0.9Ti0.1O3-δ-SDC
Authors: Abd Aziz Azreen Junaida , Baharuddin Nurul Akidah , Somalu Mahendra Rao , Muchtar Andanastuti , Haji Ahmad Sahrim
Published: June 2023

Kesan suhu sinter ke atas sifat bahan seramik perovskit SrFe0.9Ti0.1O3-δ-SDC dikaji di dalam penyelidikan ini. Pada asasnya, proses sinter dilakukan bagi memperkecilkan keliangan di dalam sesuatu bahan yang telah dipadatkan. Melalui kajian ini, tiga suhu digunakan untuk mengkaji kesan suhu sinter iaitu 1200, 1250, 1300 °C. Bahan seramik yang diperbuat daripada SDC terlebih dahulu dibentuk menjadi sel butang dengan mengenakan tekanan ekapaksi 5.2MPa. Dakwat seramik 5SrFe0.9Ti0.1O3-δ-5SDC dicetak ke atas kedua-dua permukaan sel butang bagi menghasilkan sel simetri elektrod/elektrolit/elektrod. Kesemua sel ini dibakar dengan 3 suhu sinter yang berbeza. Sifat fizikal dan morfologinya dikaji. Hasil kajian ini mendapati sel simetri yang dikenakan suhu yang berbeza mempengaruhi sifat bahan tersebut. Kenaikan suhu sinter menyebabkan bahan menjadi semakin aglomerat dan keliangan semakin berkurang sehingga 24.38%. Ketumpatan bahan juga semakin meningkat dan menyebabkan bahan mudah patah. Ketahanan bahan berkurang dengan kenaikan suhu. Dalam kajian ini, bahan 5SrFe0.9Ti0.1O3‒δ-5SDC didapati sesuai disinter pada suhu 1250 °C kerana memberikan nilai keliangan, kadar penggumpalan, ketumpatan dan dan ketahanan yang baik pada ketika itu.
Inteligencia artificial en la justicia colombiana: ¿La solución a la congestión judicial?
Authors: López Vega Juan Esteban , Becerra Valerie , Guzmán Maria de los Ángeles , Landazuri Sandovalaa John Kennedy
Published: June 2023

En el presente escrito se pretende demostrar que la aplicación de la inteligencia artificial en la justicia colombiana es necesaria como herramienta auxiliar para los jueces. Primero se discutirá sobre el problema de la congestión judicial en Colombia, y cómo este podría solucionarse con herramientas de inteligencia artificial. Luego, se explicará en términos generales el funcionamiento y utilidad de Pretoria y Prisma, además se ahondará la problemática de la congestión judicial particularmente en el contexto del derecho penal y constitucional. Finalmente, se explicará cómo estas herramientas en la justicia podrían prevenir su corrupción y se darán algunas conclusiones.
Ética y régimen biodigital: subjetividad nodo y crisis de la comunicación democrática
Authors: Pérez Valdés José Gregorio
Published: June 2023

El escrito, analizaró el impacto de las nuevas tecnologías de la información/comunicación en la sociedad actual abordada y desbordada por una pluralidad de textos, imágenes, visiones, proyectos y la producción de millones de datos que circulan las 24 horas del día y dan cuenta de la producción de un sujeto digital, el sujeto nodo, que es autor, reproductor y emisor de contenidos en diferentes niveles de conexión, con solo dar clic. Este trabajo también analiza la transformación de los conceptos de verdad y comunicación y las consecuencias para la vida social, cultural, económica, política y ambiental en el siglo XXI
¿Por qué nuestros datos importan? Conceptos claves sobre los impactos de la inteligencia artificial en la protección de los datos personales y sus marcos de regulación
Authors: Rivadeneira Christian C. , Rivera Cuellar Daniela , Riomaña Kevin
Published: June 2023

Hoy en día, cada persona en el mundo genera inmensas cantidades de información usadas por poderosos algoritmos para obtener predicciones. Dentro de este panorama, nos vemos enfrentados a un dilema importante sobre qué tan protegidos se encuentran dichos datos generados. Este documento es una introducción a este problema abordando en primer lugar el proceso de regulaciones jurídicas respecto de nuestros datos en internet, pasando por ejemplos, discusiones y polémicas, introduciendo los conceptos respecto de la Inteligencia Artificial (IA), Big Data y sesgos; finalizando con las reflexiones sobre el impacto de estos en el ámbito social, buscando de manera crítica, analizar este problema que enfrenta el mundo hoy en día, respecto del uso de nuestros datos personales en los algoritmos.
SERRA DA MIABA, POVOADO CURITUBA E VALE DOS MESTRES (SE), COMO EVIDÊNCIAS GEOLÓGICAS DE PERÍODOS GLACIAIS E INTERGLACIAIS DO PASSADO SERGIPANO
Authors: Figueiredo Felipe Torres , Da Silva Elias José , Lenz Cristine , Santana Mateus do Nascimento , Santos Andriel Lima , Gomes Pedro Victor de Oliveira
Published: June 2023

A Serra da Miaba, localizada na região centro-oeste do estado de Sergipe e o Vale dos Mestres, no extremo noroeste, compõem importantes pontos turísticos de Sergipe. Cada qual pode ser interpretado como a memória do ambiente de formação de rochas, de onde é possível extrair informações sobre climas glaciais e interglaciais na história geológica não só do Estado, mas de escala global. Contudo, apesar do tema ser muito debatido na literatura científica e de grande relevância para as discussões sobre aquecimento global, é pouco conhecido pelo grande público e por turistas. No sentido de suprir esta deficiência de informações e melhorar o conhecimento de guias e condutores de trilhas, principais agentes de comunicação com o grande público, a presente contribuição objetivou ilustrar dois exemplos de rochas que comprovam a existência de variações climáticas acompanhadas de mudanças na paisagem do passado sergipano. O primeiro exemplo está preservado na Formação Tacaratu, unidade de rochas aflorantes no Vale dos Mestres, interpretada como produto de rios ancestrais ao Rio São Francisco, capazes de transportar sedimentos por uma extensa rede de drenagens desde Sergipe até o Ceará, entre os períodos Siluriano e Devoniano, há 440-360 milhões de anos (Ma), quando a vegetação ainda era escassa sobre os continentes. No entorno do vale, próximo ao povoado Curituba, porém de idade mais jovem (Permo-carbonífera 360 – 250 Ma), estão preservadas as melhores evidências de abrasão e deformação por geleiras do Estado, em um período que a América do Sul e África estavam unidas e faziam parte de um supercontinente chamado Gondwana. Já as evidências da transição entre eventos glaciais e interglaciais de maior profundidade do tempo geológico em Sergipe, foram deixadas ao longo do Neoproterozoico (cerca de 800 Ma atrás), respectivamente, nas rochas das formações Ribeirópolis e Jacoca, localizadas na Serra da Miaba. Este registro estratigráfico, ou seja, do empilhamento das rochas, inclui Sergipe, assim como Bahia, Minas Gerais e o Mato Grosso, como uma das áreas influenciadas por processos glaciais de maiores proporções que se tem conhecimento na história do planeta.
Indonesian Defense Diplomacy in Responding to China’s National Interest in South China Sea
Authors: Waluyo Surryanto Djoko
Published: June 2023

Economic interests dominating the interests of both claimant and non-claimant-states make the South China Sea conflict challenging to obtain a satisfactory solution for all parties. In protecting its financial security, mainly dependent on the South China Sea, China continues to exhibit aggressiveness and firmness in realizing its national interests in this area, thereby raising the conflict tension. This study analyzed Indonesia’s defense diplomacy to counter China’s national interests in the South China Sea. Defense diplomacy is expected to eliminate any obstacles hindering the achievement of the two countries’ national interests. This study utilized a descriptive qualitative method with primary data obtained through interviews with defense strategists, defense diplomacy actors, academics, and other supporting secondary data. This study discovered that China’s national interests in the South China Sea center on securing its economic interests and military modernization. Meanwhile, Indonesia’s national interests in the South China Sea concern the Exclusive Economic Zone (EEZ) waters. Maintaining the integrity of the Unitary Republic of Indonesia is one of its national interests. Thus, Indonesia’s defense diplomacy should be conducted through win-win cooperation to promote its national interests in responding to China’s national interests in the South China Sea.
Prospering the ASEAN Community: How Micro-Region Becomes a Driving Force Prosperity in Indonesia’s Border Area?
Authors: Munir Fitrisia , Yani Yanyan Mohammad , Prayuda Rendi , Yudilla Artha , Sasmi Dini Tiara
Published: June 2023

Providing space for sub-state actors’ actions at the micro-regional level is a significant trend in advancing regional integration in ASEAN. Transnational activities have contributed to the trade development and optimization of each country’s local production, a strategic goal, and micro-regions have emerged as critical players in this activity. Regional integration will be localized if sub-state actors play a significant role and engage in smaller regionalism activities, such as in border areas. With the goal of encouraging prosperity and reducing development gaps, especially for people in border areas, this research examined the collaboration of sub-state actors across ASEAN countries as an alternative development paradigm. Alternative research hypotheses applicable in various scientific disciplines were included in this research through a qualitative analysis method and a reflective case study approach. This research focused on the roles and activities of sub-state actors in border areas such as the Riau Islands with Malaysia and Singapore, who could work hard together with other sub-state actor entities through the support of a strong leadership network to take quicker and more efficient actions to overcome various issues. This research strengthens the existing literature by discovering that the collaboration of sub-state actors between countries in the border region has played a big role in encouraging the border community to advance and compete in the international arena, and ASEAN has become an institution encouraging and guaranteeing equal development for people in the border areas.
El sindicalismo peronista en el Partido Justicialista de Córdoba y el parlamento provincial (1983-1989)
Authors: Roland Ernesto , Sapp Camila , Gerbaldo Juan
Published: June 2023

Este artículo reconstruye la inserción del sindicalismo peronista en el Partido Justicialista (PJ) de Córdoba durante la reconstrucción democrática (1983-1989). Para ello, daremos cuenta de las transformaciones operadas en el vínculo entre la rama política y la rama sindical con el ascenso de la corriente interna denominada Renovación Peronista (RP). Por un lado, consideraremos las estrategias de los distintos nucleamientos sindicales, su gravitación en la vida del partido, así como sus alineamientos con las distintas fracciones de la rama política. A su vez, daremos cuenta de la nominación de candidatos de extracción sindical a cargos públicos, problematizando su conceptualización como variable indicativa de una “desindicalización” del peronismo durante los años ochenta. Por último, reconstruiremos la actividad legislativa de los diputados de extracción sindical electos por el PJ ante la Cámara de Diputados de la Provincia de Córdoba, haciendo hincapié en sus iniciativas, agendas de trabajo y su articulación con otros actores.
Tecnologías de Inteligencia Artificial (AI) en el mantenimiento de activos del sector eléctrico
Authors: Galo José , Di Martino Enrico , Velásquez Bermúdez Jesús María , Delgadillo Gomez Alberto
Published: June 2023

El presente estudio ofrece una visión global sobre la importancia de abordar el Mantenimiento de Activos del sector eléctrico, en el marco de las Tecnologías de Inteligencia Artificial y nuevas tecnologías, mediante la implementación de metodologías de analítica avanzada (Mantenimiento Pronostico de la Salud, Prognostic Health Maintenance o PHM) para lograr una posición competitiva en términos de minimización de costes y maximización de beneficios.