bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-Inflammatory Effects of Minor Cannabinoids CBC, THCV, and CBN in Human Macrophages
Authors: Gojani Esmaeel Ghasemi , Wang Bo , Li Dong-Ping , Kovalchuk Olga , Kovalchuk Igor
Published: September 2023

Inflammation is a natural response of the body to signals of tissue damage or infection caused by pathogens. However, when it becomes imbalanced, it can lead to various disorders such as cancer, obesity, cardiovascular problems, neurological conditions, and diabetes. The endocannabinoid system, which is present throughout the body, plays a regulatory role in different organs and influences functions such as food intake, pain perception, stress response, glucose tolerance, inflammation, cell growth and specialization, and metabolism. Phytocannabinoids derived from Cannabis sativa can interact with this system and affect its functioning. In this study, we investigate the mechanisms underlying the anti-inflammatory effects of three minor phytocannabinoids including tetrahydrocannabivarin (THCV), cannabichromene (CBC), and cannabinol (CBN) using an in vitro system. We pre-treated THP-1 macrophages with different doses of phytocannabinoids or vehicle for one hour, followed by treating the cells with 500 ng/mL of LPS or leaving them untreated for three hours. To induce the second phase of NLRP3 inflammasome activation, LPS-treated cells were further treated with 5 mM ATP for 30 min. Our findings suggest that the mitigation of the PANX1/P2X7 axis plays a significant role in the anti-inflammatory effects of THCV and CBC on NLRP3 inflammasome activation. Additionally, we observed that CBC and THCV could also downregulate the IL-6/TYK-2/STAT-3 pathway. Furthermore, we discovered that CBN may exert its inhibitory impact on the assembly of the NLRP3 inflammasome by reducing PANX1 cleavage. Interestingly, we also found that the elevated ADAR1 transcript responded negatively to THCV and CBC in LPS-macrophages, indicating a potential involvement of ADAR1 in the anti-inflammatory effects of these two phytocannabinoids. THCV and CBN inhibit P-NF-κB, downregulating proinflammatory gene transcription. In summary, THCV, CBC, and CBN exert anti-inflammatory effects by influencing different stages of gene expression: transcription, post-transcriptional regulation, translation, and post-translational regulation.
Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity
Authors: Zhao Hua , Zhao Yufen
Published: September 2023

Multicomponent reactions (MCRs) have undoubtedly emerged as the most indispensable tool for organic chemists worldwide, finding extensive utility in the synthesis of intricate natural products, heterocyclic molecules with significant bioactivity, and pharmaceutical agents. The multicomponent one-pot 1,3-dipolar cycloaddition reactions, which were initially conceptualized by Rolf Huisgen in 1960, find extensive application in contemporary heterocyclic chemistry. In terms of green synthesis, the multicomponent 1,3-dipolar cycloaddition is highly favored owing to its numerous advantages, including high step- and atom-economies, remarkable product diversity, as well as excellent efficiency and diastereoselectivity. Among the numerous pieces of research, the most fascinating reaction involves the utilization of azomethine ylides generated from isatins and amino acids that can be captured by various dipolarophiles. This approach offers a highly efficient and convenient method for constructing spiro-pyrrolidine oxindole scaffolds, which are crucial building blocks in biologically active molecules. Consequently, this review delves deeper into the dipolarophiles utilized in the 1,3-dipolar cycloaddition of isatins and amino acids over the past six years.
Synthesis and Characterization of Azido- and Nitratoalkyl Nitropyrazoles as Potential Melt-Cast Explosives
Authors: Reinhardt Elena , Lenz Tobias , Bauer Lukas , Stierstorfer Jörg , Klapötke Thomas M.
Published: September 2023

Desirable advancements in the field of explosive materials include the development of novel melt-castable compounds with melting points ranging from 80 to 110 °C. This is particularly important due to the limited performance and high toxicity associated with TNT (trinitrotoluene). In this study, a series of innovative melt-castable explosives featuring nitratoalkyl and azidoalkyl functionalities attached to the 3-nitro-, 4-nitro-, 3,4-dinitropyrazole, or 3-azido-4-nitropyrazole scaffold are introduced. These compounds were synthesized using straightforward methods and thoroughly characterized using various analytical techniques, including single-crystal X-ray diffraction, IR spectroscopy, multinuclear nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, elemental analysis, and DTA. Furthermore, the energetic properties such as (theoretical) performance data, sensitivities, and compatibilities of the compounds were evaluated and compared among the different structures.
Removal of Hexamethyldisiloxane via a Novel Hydrophobic (3–Aminopropyl)Trimethoxysilane-Modified Activated Porous Carbon
Authors: Lv Siqi , Wang Yingrun , Zheng Yanhui , Ma Zichuan
Published: September 2023

Volatile methyl siloxanes (VMS) must be removed because the formation of silica in the combustion process seriously affects the resource utilization of biogas. Herein, a series of APTMS ((3–aminopropyl)trimethoxysilane)-modified activated porous carbon (APC) adsorbents (named APTMS@APC) were prepared for VMS efficient removal. The as-prepared adsorbents were characterized using SEM, FTIR, Raman, X-ray diffraction analyses, and N2 adsorption/desorption. The results showed that the surface modification with APTMS enhanced the hydrophobicity of APC with the water contact angle increasing from 74.3° (hydrophilic) to 127.1° (hydrophobic), and meanwhile improved its texture properties with the SBET increasing from 981 to 1274 m2 g−1. The maximum breakthrough adsorption capacity of APTMS@APC for hexamethyldisiloxane (L2, model pollutant) was 360.1 mg g−1. Effects of an inlet L2 concentration (31.04–83.82 mg L−1) and a bed temperature (0–50 °C) on the removal of L2 were investigated. Meanwhile, after five adsorption–desorption cycles, the APTMS@APC demonstrated a superior cycling performance. This indicated that the hydrophobic APTMS@APC has a great significance to remove VMS.
Magnetic Adsorbent Fe3O4/ZnO/LC for the Removal of Tetracycline and Congo Red from Aqueous Solution
Authors: Zhao Anjiu , Tang Qi , Chen Yuanlong , Qiu Chongpeng , Huang Xingyan
Published: September 2023

Zeolitic imidazolate frameworks (ZIFs) can be used as an adsorbent to efficiently adsorb organic pollutants. However, ZIF nanoparticles are easy to form aggregates, hampering the effective and practical application in practical adsorption. In this study, the ZIF-8 was successfully loaded onto lignocellulose (LC) to further produce ZnO/LC by in situ growth method and hydrothermal treatment, and then Fe3O4 nanoparticles (Fe3O4 NPs) were loaded onto ZnO/LC to prepare magnetic Fe3O4/ZnO/LC adsorbent for removing tetracycline (TC) and congo red (CR) pollutants from aqueous solution. The adsorption properties of the adsorbent were systematically analyzed for different conditions, such as adsorbent dosage, solution pH, contact time, temperature and initial concentration. The experimental data were fitted using adsorption kinetic and isotherm models. The results showed that the pseudo-second-order model and Sips model were well fitted to the adsorption kinetic and adsorption isotherm, respectively. The adsorption capacities of TC and CR reached the maximum value of 383.4 mg/g and 409.1 mg/g in experimental conditions. The mechanism of the removal mainly includes electrostatic interaction, hydrogen bonding and π-π stacking. This novel adsorbent could be rapidly separated from the aqueous solution, suggesting its high potential to remove pollutants in wastewater.
Ag-Doped MoSe2/ZnO Heterojunctions: A Highly Responsive Gas-Sensitive Material for Selective Detection of NO Based on DFT Study
Authors: He Tao , Liu Hongcheng , Zhang Jing , Yang Yuepeng , Jiang Yuxiao , Zhang Ying , Feng Jiaqi , Hu Kelin
Published: September 2023

In this work, the adsorption and sensing behavior of Ag-doped MoSe2/ZnO heterojunctions for H2, CH4, CO2, NO, CO, and C2H4 have been studied based on density functional theory (DFT). In gas adsorption analysis, the adsorption energy, adsorption distance, transfer charge, total electron density, density of states (DOS), energy band structure, frontier molecular orbital, and work function (WF) of each gas has been calculated. Furthermore, the reusability and stability of the Ag-doped MoSe2/ZnO heterojunctions have also been studied. The results showed that Ag-doped MoSe2/ZnO heterojunctions have great potential to be a candidate of highly selective and responsive gas sensors for NO detection with excellent reusability and stability.
The Role of One-Carbon Metabolism in Healthy Brain Aging
Authors: Virdi Sapna , McKee Abbey M. , Nuthi Manogna , Jadavji Nafisa M.
Published: September 2023

Aging results in more health challenges, including neurodegeneration. Healthy aging is possible through nutrition as well as other lifestyle changes. One-carbon (1C) metabolism is a key metabolic network that integrates nutritional signals with several processes in the human body. Dietary supplementation of 1C components, such as folic acid, vitamin B12, and choline are reported to have beneficial effects on normal and diseased brain function. The aim of this review is to summarize the current clinical studies investigating dietary supplementation of 1C, specifically folic acid, choline, and vitamin B12, and its effects on healthy aging. Preclinical studies using model systems have been included to discuss supplementation mechanisms of action. This article will also discuss future steps to consider for supplementation. Dietary supplementation of folic acid, vitamin B12, or choline has positive effects on normal and diseased brain function. Considerations for dietary supplementation to promote healthy aging include using precision medicine for individualized plans, avoiding over-supplementation, and combining therapies.
Association of Possible Sarcopenia or Sarcopenia with Body Composition, Nutritional Intakes, Serum Vitamin D Levels, and Physical Activity among Patients with Type 2 Diabetes Mellitus in Taiwan
Authors: Hsu Yu-Ting , Lin Jian-Yu , Lin Chien-Ju , Lee Yau-Jiunn , Chang Wen-Hsin
Published: September 2023

This study estimates the association between sarcopenia and blood biochemical parameters, nutritional intake, anthropometric measurements, physical performance, and physical activity in patients with type 2 diabetes mellitus (T2DM). Participants were recruited from a primary care clinic in Kaohsiung City. According to the diagnosis criteria of the Asian Working Group for Sarcopenia (AWGS) in 2019, 110 patients with T2DM (aged 50–80 years) were divided into three groups: non-sarcopenia (n = 38), possible sarcopenia (n = 31), and sarcopenia (n = 41). Blood samples were collected, and nutritional intake was evaluated by a registered dietitian. A food frequency questionnaire and a Godin leisure-time exercise questionnaire were used to assess their daily vitamin D intake and physical activity. There were significant differences in age, serum vitamin D levels, nutritional intake, anthropometric measurements, and physical performance between the three groups. In elderly patients with T2DM, reduced serum 25-hydroxyvitamin D [25(OH)D] levels and daily energy intake were significantly associated with possible sarcopenia. Age, lower BMI, reduced serum 25(OH)D, and reduced dietary protein and vitamin D intake were significantly associated with sarcopenia. These findings may serve as the basis for intervention trials to reduce the prevalence of sarcopenia.
Inflammatory and Metabolic Biomarker Assessment in a Randomized Presurgical Trial of Curcumin and Anthocyanin Supplements in Patients with Colorectal Adenomas
Authors: Macis Debora , Briata Irene Maria , D’Ecclesiis Oriana , Johansson Harriet , Aristarco Valentina , Buttiron Webber Tania , Oppezzi Massimo , Gandini Sara , Bonanni Bernardo , DeCensi Andrea
Published: September 2023

Colorectal cancer prevention is crucial for public health, given its high mortality rates, particularly in young adults. The early detection and treatment of precancerous lesions is key to preventing carcinogenesis progression. Natural compounds like curcumin and anthocyanins show promise in impeding adenomatous polyp progression in preclinical models. We conducted a randomized, double-blind, placebo-controlled, phase II presurgical trial in 35 patients with adenomatous polyps to explore the biological effects of curcumin and anthocyanins on circulating biomarkers of inflammation and metabolism. No significant difference in biomarker changes by treatment arm was observed. However, the network analysis before treatment revealed inverse correlations between adiponectin and BMI and glycemia, as well as direct links between inflammatory biomarkers and leptin and BMI. In addition, a considerable inverse relationship between adiponectin and grade of dysplasia was detected after treatment (corr = −0.45). Finally, a significant increase in IL-6 at the end of treatment in subjects with high-grade dysplasia was also observed (p = 0.02). The combined treatment of anthocyanins and curcumin did not result in the direct modulation of circulating biomarkers of inflammation and metabolism, but revealed a complex modulation of inflammatory and metabolic biomarkers of colon carcinogenesis.
Epidemiological Impact of Metabolic Syndrome in Overweight and Obese European Children and Adolescents: A Systematic Literature Review
Authors: Orsini Francesca , D’Ambrosio Floriana , Scardigno Anna , Ricciardi Roberto , Calabrò Giovanna Elisa
Published: September 2023

The prevalence of overweight and obesity is continuously increasing, both in the adult and pediatric populations, posing a substantial challenge to public health. Understanding the epidemiological burden of metabolic syndrome (MetS) among children, particularly regarding its complications and long-term effects in adulthood, is crucial for identifying effective preventive measures and enhancing the clinical care of obese children. Therefore, by searching two databases, a systematic review was conducted in order to evaluate studies that specifically addressed the epidemiological MetS impact among overweight/obese European children and adolescents. Overall, 15 studies were considered. The epidemiological data concerning the MetS impact were contingent on the diagnostic criteria used and varied across countries, resulting in a prevalence range of 1.44% to 55.8%. Spanish studies were the most numerous (34%), revealing a country prevalence rate ranging from 2.5% to 19.6%. Males (prevalence range: 1.4–55.8%) and subjects with overweight/obesity (prevalence range: 12.9–55.8%) were mainly affected. Obesity emerged as the main risk factor in the MetS development and the consequent onset of cardiovascular complications and diabetes. Knowing the MetS burden and its risk factors could improve their prevention, detection, and treatment, and guide the development of targeted public health interventions to appropriately address the health needs of younger patients.
The Effects of Flavonoids on Skeletal Muscle Mass, Muscle Function, and Physical Performance in Individuals with Sarcopenia: A Systematic Review of Randomized Controlled Trials
Authors: Wu Cong , Suzuki Katsuhiko
Published: September 2023

Sarcopenia has become a significant obstacle to healthy aging in older adults. Flavonoids may contribute to treating sarcopenia, and attenuate the age-related loss of skeletal muscle mass, muscle strength, and physical function, however, their benefits in sarcopenic individuals remain unclear. This systematic review aimed to evaluate the effect of flavonoids on muscle mass, muscle strength, and physical performance in adults with sarcopenia based on randomized controlled trials (RCTs). This review was conducted in conformity with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the risk of bias was assessed using the Cochrane risk of bias tool. The article search was conducted using PubMed, Scopus, Embase, Cochrane, Web of Science databases, and Google Scholar for the period until June 2023. RCTs that assessed the effects of flavonoids/flavonoids combined with other supplementation/flavonoid-rich supplementations on skeletal muscle mass, muscle strength, and physical performance in adults diagnosed with sarcopenia before intervention were included. From the 309 articles found, a total of 6 RCTs met the inclusion criteria. RCTs evaluated the main outcomes of tea catechins, epicatechin, and isoflavones intervention. Skeletal muscle mass significantly increased in three studies, muscle strength significantly elevated in two studies, and physical performance significantly improved in two studies. The majority of studies (five in six) found at least one of the main outcomes is elevated by flavonoids intervention. Flavonoids may have a great potential to treat sarcopenia.
Support from a Best Friend Makes People Eat Less under Stress: Evidence from Two Experiments
Authors: Xiao Mingyue , Luo Yijun , Zeng Weiyu , Chen Hong
Published: September 2023

When experiencing acute stress, individuals often turn to eating for comfort, as it provides a sense of satiety and satisfaction that can temporarily alleviate the stressful condition. However, this may increase the risk of obesity, diabetes, cardiovascular disease. In this study, we conducted two behavioral experiments to investigate the effectiveness of social support in reducing stress-induced overeating and the mediative role of negative affect and self-efficacy (Experiment 1), as well as the role of reward sensitivity (Experiment 2). Acute stress was induced using a speech preparation task and then participants were asked to regulate their emotions and cognition, either alone or with the help of pictures and supportive sentences provided by a best friend or stranger. Participants in Experiment 1 then completed the food choice task, and participants in Experiment 2 completed the food incentive delay task and the bogus tasting task. The results of both experiments consistently showed that participants who received support from their friends reported lower levels of perceived stress, chose fewer food portions, and consumed fewer snacks during acute stress, compared to the other three groups. Further mediation analysis using the process macro revealed that the differential influence of social support on the choice of high-calorie foods was due to decreased negative affect and increased self-efficacy. This study provides valuable insights for the development of therapeutic interventions for clinical eating disorders.
Lifestyle Factors and Energy Intakes with Risks of Breast Cancer among Pre- and Post- Menopausal Women in Taiwan
Authors: Huang Meng-Chuan , Huang Tz-Ting , Feng Hsin-Chun , Chen I-Chun , Chang Chiao-I , Wang Tsu-Nai , Kuo Wen-Hung , Wang Ming-Yang , Tsai Li-Wei , Li Szu-Yi , Huang Chiun-Sheng , Lu Yen-Shen , Lin Ching-Hung
Published: September 2023

Although the incidence of invasive breast cancer (BC) among women in Asian is generally lower than that in Western countries, the incidence of BC has been on the rise in the past three decades in Asian countries. This hospital-based case-control study aimed to explore the relationship between dietary and metabolic factors and BC risk in pre- and post-menopausal women. We enrolled 285 patients with newly diagnosed BC at the National Taiwan University Hospital and 297 controls from the local community and hospital staff. Before receiving anticancer therapy, all patients with BC and control participants completed a 57-question semi-quantitative Food Frequency Questionnaire. For pre-menopausal women, plant-based factor scores rich in seeds and nuts, soy, fruits, and seaweeds correlated significantly with reduced BC risks, whereas menarche occurring at <12 years of age, reduced physical activity, and high-density lipoprotein <40 mg/dL were associated with increased BC risks. For post-menopausal women, plant-based dietary factor scores were also associated with reduced risks, whereas increased body mass index and energy intake levels correlated with increased BC risks. Diets rich in plant-based dietary patterns are protective against BC risk, regardless of menopausal status. Habitual physical activity is protective against BC risk among pre-menopausal Taiwanese women. Maintaining optimal weight and caloric intake is beneficial for reducing post-menopausal BC risk.
Sleep Quality and Its Relationship to Anxiety and Hardiness in a Cohort of Frontline Italian Nurses during the First Wave of the COVID-19 Pandemic
Authors: Baldassini Rodriguez Samuele , Bardacci Yari , El Aoufy Khadija , Bazzini Marco , Caruso Christian , Giusti Gian Domenico , Mezzetti Andrea , Lucchini Alberto , Iozzo Pasquale , Guazzini Andrea , Magi Camilla Elena , Iovino Paolo , Longobucco Yari , Rasero Laura , Bambi Stefano
Published: September 2023

Introduction: The COVID-19 pandemic has had a considerable impact on the psychological and psychopathological status of the population and health care workers in terms of insomnia, anxiety, depression, and post-traumatic stress disorder. The primary aim of this study was to describe and evaluate the impact of the pandemic on insomnia levels of a cohort of Italian nurses, particularly those involved in the care of COVID-19 patients. The secondary aim was to identify the interaction between insomnia and hardiness, anxiety, and sleep disturbances. Materials and Methods: A descriptive–exploratory study was conducted using an online survey during the first wave of the COVID-19 pandemic (March to July 2020). The questionnaire consisted of multiple-choice, open-ended, closed, and semi-closed questions. The psychometric tools administered were the Dispositional Resilience Scale (DRS-15), the State–Trait Anxiety Inventory (STAI-Y), and the Insomnia Severity Index (ISI). Results: a cohort of 1167 nurses fully completed the questionnaire (86.2% of total respondents). The insomnia scale survey showed an increase in post-pandemic scores compared to those before the pandemic, implying that insomnia levels increased after the first pandemic wave. Insomnia scores were directly correlated with anxiety levels (r = 0.571; p ≤ 0.05) and inversely correlated with hardiness levels (r = −0.324; p < 0.001). Multivariate analysis revealed the following protective factors: not having worked in COVID-19 wards, high levels of hardiness (commitment), and the presence of high pre-pandemic insomnia disorder. The main risk factor for insomnia reported in the analysis was a high anxiety score. Discussion and Conclusion: Anxiety represented the main risk factor for insomnia severity in our sample, while hardiness was confirmed as a protective factor. Thus, it is necessary to design further studies to identify additional risk factors for poor sleep quality and to develop educational courses and strategies aimed at enhancing rest and sleep quality, especially for frontline nurses.
Antioxidant Effect of the Ethyl Acetate Extract of Potentilla indica on Kidney Mitochondria of Streptozotocin-Induced Diabetic Rats
Authors: Landa-Moreno Cinthia I. , Trejo-Hurtado Cristian M. , Lemus-de la Cruz Jenaro , Peña-Montes Donovan J. , Murillo-Villicaña Marina , Huerta-Cervantes Maribel , Montoya-Pérez Rocío , Salgado-Garciglia Rafael , Manzo-Avalos Salvador , Cortés-Rojo Christian , Monribot-Villanueva Juan Luis , Guerrero-Analco José Antonio , Saavedra-Molina Alfredo
Published: September 2023

Diabetes mellitus (DM) is a metabolic disorder characterized by persistent hyperglycemia. This state may lead to an increase in oxidative stress, which contributes to the development of diabetes complications, including diabetic kidney disease. Potentilla indica is a traditional medicinal herb in Asia, employed in the treatment of several diseases, including DM. In this study, we investigated the antioxidant effect of the ethyl acetate extract of Potentilla indica both in vitro and on kidneys of streptozotocin-induced diabetic male rats. Firstly, phytochemicals were identified via UPLC-MS/MS, and their in vitro antioxidant capabilities were evaluated. Subsequently, male Wistar rats were assigned into four groups: normoglycemic control, diabetic control, normoglycemic treated with the extract, and diabetic treated with the extract. At the end of the treatment, fasting blood glucose (FBG) levels, creatinine, blood urea nitrogen (BUN), and uric acid were estimated. Furthermore, the kidneys were removed and utilized for the determination of mitochondrial reactive oxygen species (ROS) production, mitochondrial respiratory chain complex activities, mitochondrial lipid peroxidation, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities. The in vitro findings showed that the major phytochemicals present in the extract were phenolic compounds, which exhibited a potent antioxidant activity. Moreover, the administration of the P. indica extract reduced creatinine and BUN levels, ROS production, and lipid peroxidation and improved mitochondrial respiratory chain complex activity and GSH-Px, SODk, and CAT activities when compared to the diabetic control group. In conclusion, our data suggest that the ethyl acetate extract of Potentilla indica possesses renoprotective effects by reducing oxidative stress on the kidneys of streptozotocin-induced diabetic male rats.
Identification and Genome-Wide Gene Expression Perturbation of a Trisomy in Chinese Kale (Brassica oleracea var. alboglabra)
Authors: Feng Qun , Yu Junxing , Yu Jie , Hu Mingyang , Gu Lei , Wang Hongcheng , Du Xuye , Zhu Bin , Cai Mengxian
Published: September 2023

Trisomy harbouring an extra copy of the chromosome generally causes a variety of physical and intellectual disabilities in mammals but is an extremely rare and important genetic stock in plants. In this study, a spontaneous trisomy plant in a Chinese kale accession (Brassica oleracea var. alboglabra, CC, 2n = 18) that showed significantly smaller plant architecture when compared to other normal plants was found and subsequently confirmed by cytological analysis in which the chromosome set of 2n = 19 and abnormal chromosome behaviour were observed. Then, based on the gene expression deviation determined by RNA-seq, the extra chromosome copy in this trisomy was identified as chromosome C2 (TC2). Compared to normal plants, TC2 not only showed generally upregulated differentially expressed genes (DEGs) on chromosome C2 (97.21% of 573 DEGs in chromosome C2) but also exhibited a whole-genome expression perturbation, in which 1329 DEGs (69.87% of total DEGs) were observed along two-copy chromosomes (trans-effect). The genes in the high (gene expression value > 100) and medium (100 > gene expression value > 10) groups were more prone to decreased gene expression, but the genes in the low group (10 > gene expression value > 0.1) showed upregulated expression deviation. In addition, GO (Gene ontology) annotation analysis revealed that the upregulated DEGs in the trans-effect group were overrepresented by the genes involved in the response to stress category, while the downregulated DEGs in the trans-effect group were mostly enriched in pathways related to DNA synthesis. In conclusion, we think our results can provide important resources for genetic analysis in B. oleracea and show some novel insights for understanding trisomy plant biology.
Temperature-Sensitive Fragrance Microcapsules with Double Capsule Walls: A Study on Preparation and Sustained Release Mechanism
Authors: Yang Qun , Hu Genghao , Qiu Huili , Mia Rajib , Zhang Hongjuan , Pei Liujun , Wang Jiping
Published: September 2023

Microcapsules are small particles that can effectively protect a core material from degradation. Microcapsules with double capsule walls can improve stability and reduce breakage due to the fact that the physical and chemical properties of double-walled materials can complement each other, thus enhancing the quality and applicability of a microcapsule. Microcapsules can achieve controlled release of core materials by using a temperature-sensitive wall material. In this research, gelatin was used as the inner wall material for these double-walled microcapsules. The outer wall material was a composite material prepared by the reaction of a hydroxyl group in gum arabic with an amino group in N-isopropylacrylamide (NIPAM) in the presence of N, N’-methylene bisacrylamide (BIS), while lavender fragrance oil served as the core material. A complex coalescence method was used for the preparation of microcapsules with double capsule walls. The effects of different proportions of gum arabic to NIPAM on the core loading, microcapsule yield and thermal stability of microcapsules were studied in detail. Additionally, the stability of these fragrance microcapsules with double capsule walls in different solvents and pH values was evaluated. The sustained release properties and mechanism of cotton fabrics treated with prepared fragrance microcapsules were investigated. The results show that the microcapsules prepared with a 10:1 ratio of NIPAM to gum arabic have good temperature responsiveness. Therefore, clothing treated with microcapsules with temperature-sensitive wall materials can ensure that the human body has a fresh and pleasant smell in the case of perspiring in summer.
Morphological Evolution of Hybrid Block Copolymer Particles: Toward Magnetic Responsive Particles
Authors: Shin Jaeman J.
Published: September 2023

The co-assembly of block copolymers (BCPs) and inorganic nanoparticles (NPs) under emulsion confinement allows facile access to hybrid polymeric colloids with controlled hierarchical structures. Here, the effect of inorganic NPs on the structure of the hybrid BCP particles and the local distribution of NPs are studied, with a particular focus on comparing Au and Fe3O4 NPs. To focus on the effect of the NP core, Au and Fe3O4 NPs stabilized with oleyl ligands were synthesized, having a comparable diameter and grafting density. The confined co-assembly of symmetric polystyrene-b-poly(1,4-butadiene) (PS-b-PB) BCPs and NPs in evaporative emulsions resulted in particles with various morphologies including striped ellipsoids, onion-like particles, and their intermediates. The major difference in PS-b-PB/Au and PS-b-PB/Fe3O4 particles was found in the distribution of NPs inside the particles that affected the overall particle morphology. Au NPs were selectively localized inside PB domains with random distributions regardless of the particle morphology. Above the critical volume fraction, however, Au NPs induced the morphological transition of onion-like particles into ellipsoids by acting as an NP surfactant. For PS-b-PB/Fe3O4 ellipsoids, Fe3O4 NPs clustered and segregated to the particle/surrounding interface of the ellipsoids even at a low volume fraction, while Fe3O4 NPs were selectively localized in the middle of PB domains in a string-like pattern for PS-b-PB/Fe3O4 onion-like particles.
Wearable Liquid Metal Composite with Skin-Adhesive Chitosan–Alginate–Chitosan Hydrogel for Stable Electromyogram Signal Monitoring
Authors: Kim Jaehyon , Kim Yewon , Lee Jaebeom , Shin Mikyung , Son Donghee
Published: September 2023

In wearable bioelectronics, various studies have focused on enhancing prosthetic control accuracy by improving the quality of physiological signals. The fabrication of conductive composites through the addition of metal fillers is one way to achieve stretchability, conductivity, and biocompatibility. However, it is difficult to measure stable biological signals using these soft electronics during physical activities because of the slipping issues of the devices, which results in the inaccurate placement of the device at the target part of the body. To address these limitations, it is necessary to reduce the stiffness of the conductive materials and enhance the adhesion between the device and the skin. In this study, we measured the electromyography (EMG) signals by applying a three-layered hydrogel structure composed of chitosan–alginate–chitosan (CAC) to a stretchable electrode fabricated using a composite of styrene–ethylene–butylene–styrene and eutectic gallium-indium. We observed stable adhesion of the CAC hydrogel to the skin, which aided in keeping the electrode attached to the skin during the subject movement. Finally, we fabricated a multichannel array of CAC-coated composite electrodes (CACCE) to demonstrate the accurate classification of the EMG signals based on hand movements and channel placement, which was followed by the movement of the robot arm.
Design of Superlubricity System Using Si3N4/Polyimide as the Friction Pair and Nematic Liquid Crystals as the Lubricant
Authors: Gao Xinlei , Cheng Yuwei , Shi Miaomiao , Chen Hao , Wu Li , Wang Tingting
Published: September 2023

Polyimide (PI) is a high-performance engineering plastic used as a bearing material. A superlubricity system using Si3N4/PI as the friction pair and nematic liquid crystals (LCs) as the lubricant was designed. The superlubricity performance was studied by simulating the start-stop condition of the machine, and it was found that the superlubricity system had good reproducibility and stability. In the superlubricity system, friction aligned with the PI molecules, and this alignment was less relevant compared to which substance was rubbing on the PI. Oriented PI molecules induced LC molecule alignment when the pretilt angle was very small, and the LC molecules were almost parallel to the PI molecules due to the one-dimensional ordered arrangement of LC molecules and low viscosity, which is conducive to the occurrence of the superlubricity phenomenon.
Dimensional Methods Used in the Additive Manufacturing Process
Authors: Száva Ioan , Vlase Sorin , Scutaru Maria Luminița , Asztalos Zsolt , Gálfi Botond-Pál , Șoica Adrian , Șoica Simona
Published: September 2023

It is a well-known fact that in the field of modern manufacturing processes, additive manufacturing (AM) offers unexpected opportunities for creativity and rapid development. Compared with classical manufacturing technologies, AM offers the advantages of reducing weight and improving performance and offers excellent design capabilities for prototyping and rapid sample manufacture. To achieve its full potential regarding cost, durability, material consumption, and rigidity, as well as maintaining competitiveness, there are several research directions that have not been explored. One less frequently explored direction is the involvement of dimensional methods in obtaining an optimal and competitive final product. In this review, we intend to discuss the ways in which dimensional methods, such as geometric analogy, similarity theory, and dimensional analysis, are involved in addressing the problems of AM. To the best of our knowledge, it appears that this field of engineering has not fully maximized the advantages of these dimensional methods to date. In this review, we survey mainly polymer-based AM technology. We focus on the design and optimization of highly competitive products obtained using AM and also on the optimization of layer deposition, including their orientation and filling characteristics. With this contribution to the literature, we hope to suggest a fruitful direction for specialists involved in AM to explore the possibilities of modern dimensional analysis.
Fractal Characterization of Particle Size and Coordinate Distribution of Dispersed Phase in the Steelmaking Process of Combined Blowing Conversion
Authors: Chen Shiyi , Zhou Xiaolei , Zheng Zhihao , Chen Ren , Yu Shan , Shi Chunyang
Published: September 2023

A two-dimensional water model was used to simulate the process of combined blowing. The effect of boundary conditions on the size and coordinate distribution of the dispersed phase was investigated. The results showed that the frequency of the dispersed phase at a certain size level is proportional to its size; the coordinates of the dispersed phase can be expressed in a dimensionless form that shows its uniformity of distribution. An empirical equation for the influence of the boundary conditions on the size and coordinate distribution of the dispersed phase in combined blowing process is also presented.
Fe3O4@Granite: A Novel Magnetic Adsorbent for Dye Adsorption
Authors: Topal Canbaz Gamze
Published: September 2023

Magnetic granite (MG), a new and low-cost adsorbent, was prepared by the chemical co-precipitation of Fe2+ and Fe3+ using granite (G), which is a magmatic rock type. The adsorption of the Reactive Black 5 (RB5) dye from aqueous solutions on Fe3O4-modified granite was examined in a batch system. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), X-ray fluorescence spectrometry (XRF), X-ray diffractometry (XRD), N2 adsorption–desorption, vibrating-sample magnetometry (VSM), and point-of-zero charge (pHpzc) analysis were used to characterize the prepared MG. Magnetic granite displayed significant magnetization and could be easily separated using external magnets. The maximum adsorption capacity was 29.85 mg/g at 298 K. According to kinetic and isothermal examinations, the pseudo-second-order model and Langmuir isothermal adsorption were the best fit for adsorption. It was found that the enthalpy change ΔH (kJ/mol) was −31.76, and the entropy change ΔS (kJ/mol) was 0.096 for a temperature change of 298–330 K. The ΔG° (kJ/mol) value was negative at all temperatures (298 K, −2.86 kJ/mol; 303 K, −2.85 kJ/mol and 313 K, −1.50 kJ/mol), indicating that the adsorption of RB5 on MG was spontaneous.
New Resources for Sustainable Thermal Insulation Using Textile and Agricultural Waste in a New Circular Economy Approach: An Overview
Authors: Biyada Saloua , Merzouki Mohammed , Urbonavičius Jaunius
Published: September 2023

Energy conservation has emerged as a strategic target worldwide, which will enable the protection of the environment and the preservation of natural resources. Energy consumption in buildings for heating and cooling is considered one of the main sources of energy consumption in several countries. For this reason, there is an ongoing search for appropriate alternatives to preserve energy and reduce energy losses. To overcome this challenge, thermal insulation is becoming increasingly essential to save energy. Although a large number of insulation materials are used commercially, this sector still faces various challenges such as cost, thermal and mechanical properties, the end-of-life cycle, as well as health issues, etc. Furthermore, the harmful impact of buildings on the environment and health issues should be considered not only in relation to the energy expended whilst using them but also in relation to the energy performance materials they are constructed from. The insulation materials commonly used in the construction industry today are polymer-based materials such as polystyrene and polyurethane foam. These materials have a critical impact on the environment. In light of these results, several researchers have concluded that it is imperative to develop insulating materials with outstanding properties that have a lower impact on the environment and are relatively affordable. Agricultural and/or industrial wastes, and even natural fibers, are increasingly used as green insulation materials, as they are an eco-friendly, cost-effective alternative to conventional oil-based materials, as well as the fact that their end-of-life cycle does not pose a critical problem. This review paper discusses the several renewable resources and industrial wastes developed as thermal insulations. Furthermore, it sheds light on composite materials used as construction materials, as well as their end-of-life cycle.
Structural Optimization of Annular Thermoelectric Module Applied to Liquefied Natural Gas Cold Energy Recovery
Authors: Zhao Yulong , Diao Hongmei , Li Wenjie , Xuan Zhiwei , Zhang Qi , Wang Yulin , Ge Minghui
Published: September 2023

The gasification of liquefied natural gas (LNG) is characterized by a substantial release of cold energy, which can be utilized for power generation via thermoelectric generator (TEG). Employing a gasifier integrated with a thermoelectric generator for LNG gasification allows for the recovery of cold energy and its conversion to useful power, a process that holds significant potential for widespread application. In the study, a thermoelectric model has been developed for an annular thermoelectric module, which formed a new category of gasifier tube. The influence of the module’s structure as well as the heat transfer parameters on the thermoelectric performance was examined. The results revealed that an optimum height of the thermoelectric leg, specifically 2 mm, maximized the output power while allowing the thermoelectric conversion efficiency to reach a peak of 3.25%. Another noteworthy finding is that an increase in the central angle of the thermoelectric leg leads to a concomitant rise in output power but a decrease in conversion efficiency. Furthermore, when the heat transfer coefficients at the hot and cold ends of the module achieved 4000 W/(m2·K) and 10,000 W/(m2·K), respectively, the conversion efficiency can be elevated to 6.98%. However, any additional enhancement in power generation performance derived from further augmenting the heat transfer is marginal. These findings can serve as a valuable reference in the design and optimization of TEG intended for the recovery of cold energy from LNG.
The Victory of the Slaughtered Lamb: A Theology of Winning (and Losing) for Christian Athletes
Authors: Gamel Brian K.
Published: September 2023

This paper explores what a notion of victory rooted in Revelation’s theological grammar might look like. Although this essay might hold interest for a variety of individuals, it is written with Christian participation in sports in mind. What might a theology of victory look like that is specifically Christological? That is the question this essay attempts to address. Before offering a theology of victory, though, we will first explore why Revelation is a place to examine this question and how others have attempted to frame their own answers.
A Pilot Project Using Sensors in the Municipal Solid Waste Collection of a Medium-Sized City
Authors: Franco-González Jerónimo , Gallardo Antonio , Carlos Mar , Edo-Alcón Natalia
Published: September 2023

Municipal solid waste collection must reach the recycling rates required by new regulations, like with the introduction of new bins to collect the organic fraction. The filling pattern of those bins is unknown, and the collection frequency and collection routes can change. Sensors can help to identify the filling degree and to reorganize the waste collection routes. Yet, equipping all the bins with new technologies can represent a significant amount of money for enterprises and public authorities. The aim of this work is to analyze the use of sensors in waste collection systems where the collection frequency is high. Bins from two zones of a town (a residential and a commercial zone) were selected, and a volumetric sensor was installed to study the filling pattern. In the first scenario, the organic fraction and the mixed waste bin were monitored. In the second experiment, data from mixed waste bins were recorded during two days of the week. Results show that the filling degree pattern is similar in all the cases and that citizens do not respect the recommended times for taking their waste out. Additionally, the cost of the sensors represents a significant amount for a medium-sized town. Although sensors can provide a great amount of information, it is not necessary to install them in all the bins but only at the points to be analyzed. This work proposes a new way to use sensors to validate and calibrate the containerization network of a town with a high collection frequency.
Analysis of Ocean–Lithosphere–Atmosphere–Ionosphere Coupling Related to Two Strong Earthquakes Occurring in June–September 2022 on the Sea Coast of Philippines and Papua New Guinea
Authors: Xu Xitong , Wang Lei , Chen Shengbo
Published: September 2023

Scientific progress in the context of seismic precursors reveals a systematic mechanism, namely lithosphere–atmosphere–ionosphere coupling (LAIC), to elaborate the underlying physical processes related to earthquake preparation phases. In this study, a comprehensive analysis was conducted for two earthquakes that occurred on the sea coast through tidal force fluctuation to investigate ocean–lithosphere–atmosphere–ionosphere coupling (OLAIC), based on oceanic parameters (i.e., sea potential temperature and seawater salinity), air temperature and electron density profiles. The interrupted enhancement and diffusion process of thermal anomalies indicate that the intensity of seismic anomalies in the atmosphere is affected by the extent of land near the epicenter. By observing the evolution of the ocean interior, we found that the deep water was lifted and formed upwelling, which then diffused along the direction of plate boundaries with an “intensification-peak-weakening” trend under the action of the accelerated subduction of tectonic plates. Furthermore, the analysis shows that the seismic anomalies have two propagation paths: (i) along active faults, with the surface temperature rising as the initial performance, then the air pressure gradient being generated, and finally the ionosphere being disturbed; (ii) along plate boundaries, upwelling, which is the initial manifestation, leading to changes in the parameters of the upper ocean. The results presented in this study can contribute to understanding the intrinsic characteristics of OLAIC.
Accuracy Assessment of Atmospheric Correction of KMSS-2 Meteor-M #2.2 Data over Northern Eurasia
Authors: Plotnikov Dmitry , Kolbudaev Pavel , Matveev Alexey , Proshin Andrey , Polyanskiy Ivan
Published: September 2023

Atmospheric correction of satellite remote sensing data is a prerequisite for a large variety of applications, including time series analysis and quantitative assessment of the Earth’s vegetation cover. It was earlier reported that an atmospherically corrected KMSS-M (Meteor-M #2) dataset was produced for Russia and neighboring countries. The methodology adopted for atmospheric correction was based on localized histogram matching of target KMSS-M and MODIS reference gap-free and date-matching imagery. In this paper, we further advanced the methodology and quantitatively assessed Level-2 surface reflectance analysis-ready datasets, operatively produced for KMSS-2 instruments over continental scales. Quantitative assessment was based on accuracy, precision, and uncertainty (APU) metrics produced for red and near-infrared bands of the KMSS-2 instrument based on a reference derived from a MODIS MOD09 reconstructed surface reflectance. We compared error distributions at 5%, 20%, and 50% levels of cloudiness and indicated that the cloudiness factor has little impact on the robustness of the atmospheric correction regardless of the band. Finally, the spatial and temporal gradients of accuracy metrics were investigated over northern Eurasia and across different seasons. It was found that for the vast majority of observations, accuracy falls within the −0.010–0.035 range, while precision and uncertainty were below 0.06 for any band. With the successful launch of the most recent Meteor-M #2.3 with a new KMSS-2 instrument onboard, the efficiency and interoperability of the constellation are expected to increase.