bluuebunny/crossref_metadata_2025 huggingface dataset:
Storm Surge and Wave Impact of Low-Probability Hurricanes on the Lower Delaware Bay—Calibration and Application
Authors: Salehi Mehrdad
Published: May 2018

Hurricanes pose major threats to coastal communities and sensitive infrastructure, including nuclear power plants, located in the vicinity of hurricane-prone coastal regions. This study focuses on evaluating the storm surge and wave impact of low-probability hurricanes on the lower Delaware Bay using the Delft3D dynamically coupled wave and flow model. The model comprised Overall and Nested domains. The Overall model domain encompassed portions of the Atlantic Ocean, Delaware Bay, and Chesapeake Bay. The two-level Nested model domains encompassed the Delaware Estuary, its floodplain, and a portion of the continental shelf. Low-probability hurricanes are critical considerations in designing and licensing of new nuclear power plants as well as in establishing mitigating strategies for existing power facilities and other infrastructure types. The philosophy behind low-probability hurricane modeling is to establish reasonable water surface elevation and wave characteristics that have very low to no probability of being exceeded in the region. The area of interest (AOI) is located on the west bank of Delaware Bay, almost 16 miles upstream of its mouth. The model was first calibrated for Hurricane Isabel (2003) and then applied to synthetic hurricanes with very low probability of occurrence to establish the storm surge envelope at the AOI. The model calibration results agreed reasonably well with field observations of water surface elevation, wind velocity, wave height, and wave period. A range of meteorological, storm track direction, and storm bearing parameters that produce the highest sustained wind speeds were estimated using the National Weather Service (NWS) methodology and applied to the model. Simulations resulted in a maximum stillwater elevation and wave height of 7.5 m NAVD88 and 2.5 m, respectively, at the AOI. Comparison of results with the U.S. Army Corps of Engineers, North Atlantic Coastal Comprehensive Study (USACE-NACCS) storm surge values at the AOI demonstrates that the estimated elevation has an annual exceedance probability of less than

10

−
4

.
Comet Pond II: Synergistic Intersection of Concentrated Extraterrestrial Materials and Planetary Environments to Form Procreative Darwinian Ponds
Authors: Clark Benton C. , Kolb Vera M.
Published: May 2018

In the “comet pond” model, a rare combination of circumstances enables the entry and landing of pristine organic material onto a planetary surface with the creation of a pond by a soft impact and melting of entrained ices. Formation of the constituents of the comet in the cold interstellar medium and our circumstellar disk results in multiple constituents at disequilibrium which undergo rapid chemical reactions in the warmer, liquid environment. The planetary surface also provides minerals and atmospheric gases which chemically interact with the pond’s organic- and trace-element-rich constituents. Pond physical morphology and the heterogeneities imposed by gravitational forces (bottom sludge; surface scum) and weather result in a highly heterogeneous variety of macro- and microenvironments. Wet/dry, freeze/thaw, and natural chromatography processes further promote certain reaction sequences. Evaporation concentrates organics less volatile than water. Freezing concentrates all soluble organics into a residual liquid phase, including CH3OH, HCN, etc. The pond’s evolutionary processes culminate in the creation of a Macrobiont with the metabolically equivalent capabilities of energy transduction and replication of RNA (or its progenitor informational macromolecule), from which smaller organisms can emerge. Planet-wide dispersal of microorganisms is achieved through wind transport, groundwater, and/or spillover from the pond into surface hydrologic networks.
Evaluation of Surface Roughness by Image Processing of a Shot-Peened, TIG-Welded Aluminum 6061-T6 Alloy: An Experimental Case Study
Authors: Atieh Anas , Rawashdeh Nathir , AlHazaa Abdulaziz
Published: May 2018

Visual inspection through image processing of welding and shot-peened surfaces is necessary to overcome equipment limitations, avoid measurement errors, and accelerate processing to gain certain surface properties such as surface roughness. Therefore, it is important to design an algorithm to quantify surface properties, which enables us to overcome the aforementioned limitations. In this study, a proposed systematic algorithm is utilized to generate and compare the surface roughness of Tungsten Inert Gas (TIG) welded aluminum 6061-T6 alloy treated by two levels of shot-peening, high-intensity and low-intensity. This project is industrial in nature, and the proposed solution was originally requested by local industry to overcome equipment capabilities and limitations. In particular, surface roughness measurements are usually only possible on flat surfaces but not on other areas treated by shot-peening after welding, as in the heat-affected zone and weld beads. Therefore, those critical areas are outside of the measurement limitations. Using the proposed technique, the surface roughness measurements were possible to obtain for weld beads, high-intensity and low-intensity shot-peened surfaces. In addition, a 3D surface topography was generated and dimple size distributions were calculated for the three tested scenarios: control sample (TIG-welded only), high-intensity shot-peened, and low-intensity shot-peened TIG-welded Al6065-T6 samples. Finally, cross-sectional hardness profiles were measured for the three scenarios; in all scenarios, lower hardness measurements were obtained compared to the base metal alloy in the heat-affected zone and in the weld beads even after shot-peening treatments.
Novel Sustainable Composites Based on Poly(hydroxybutyrate-co-hydroxyvalerate) and Seagrass Beach-CAST Fibers: Performance and Degradability in Marine Environments
Authors: Seggiani Maurizia , Cinelli Patrizia , Balestri Elena , Mallegni Norma , Stefanelli Eleonora , Rossi Alessia , Lardicci Claudio , Lazzeri Andrea
Published: May 2018

In order to produce sustainable, bio-based and highly biodegradable materials, composites based on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and fibers of Posidonia oceanica (PO), a dominant Mediterranean seagrass, were produced by simple melt mixing and characterized in terms of thermal stability, morphology and rheological/mechanical properties. In view of their potential application in marine environments, degradation of the developed composites was evaluated under simulated and real marine environmental conditions for 1 year. Using 10 wt % of acetyl tributyl citrate (ATBC) as a plasticizer, smooth processing was achieved for up to 30 wt % of PO fibers, despite the reduction of the melt fluidity observed with increasing fiber loading. The tensile modulus slightly increased (from 2 to 2.4 GPa) while the tensile strength and the elongation decreased (from 23.6 to 21.5 MPa and from 3.2 to 1.9%, respectively) by increasing the PO fiber content from 0 to 30 wt %. Interestingly, the impact resistance of the composites increased with the increasing of the PO content: the Charpy’s impact energy increased from 3.6 (without fiber) to 4.4 kJ/m2 for the composite with 30 wt %. The results of the aerobic biodegradation under simulated marine conditions showed that the presence of PO fibers favored the physical disintegration of the composite increasing the biodegradation rate of the polymeric matrix: after 216 days, the composite with 20 wt % PO fibers showed a biodegradability of about 30% compared to 20% of the composite without fibers. Under real marine conditions, the specimens containing PO fibers showed higher weight losses and deterioration of tensile properties compared to those without fibers. Presumably, biodegradation occurred after colonization of the specimen, and the specimens with 20 wt % PO fibers showed well-developed biofilm consisting of bacteria and fungi on the surface after only 3 months of incubation in marine sediments, unlike the no-fiber specimens. Consequently, the persistence of an adequate mechanical performance for a relatively long period (1 year), due to a moderate rate of biodegradation in the marine environment, make the developed PHBV/PO composites particularly suitable for the production of relatively low-cost and biodegradable items which are usable in the sea and/or sand dunes, increasing the market opportunities for biopolymers such as PHBV and, at the same time, finding an eco-sustainable valorization for the PO fibrous residues accumulated in large quantities on Mediterranean beaches, which represents a problem for coastal municipalities.
The Effects of Excess Co on the Phase Composition and Thermoelectric Properties of Half-Heusler NbCoSb
Authors: Huang Lihong , Wang Junchen , Chen Xi , He Ran , Shuai Jing , Zhang Jianjun , Zhang Qinyong , Ren Zhifeng
Published: May 2018

NbCoSb with nominal 19 valence electrons, and is supposed to be metallic, has recently been reported to also exhibit the thermoelectric properties of a heavily doped n-type semiconductor. In this study, we prepared Co-rich NbCo1+xSb samples (x = 0, 0.2, 0.3, 0.4, 0.5), and their phase compositions, microstructures and thermoelectric properties were investigated. The Seebeck coefficient increased a great deal with increasing x, due to decreasing carrier concentration, and the total thermal conductivity reduced mainly because of declining κe. Finally, a peak thermoelectric figure of merit, ZT, was about 0.46 for NbCo1.3Sb at 973 K. This enhancement was mainly attributed to the reduction of electric thermal conductivity and the increase of Seebeck coefficient. The excess Co had effects on the carrier concentration, deformation potential Edef and DOS effective mass m*. Adding an excessive amount of Co leads to a very high Edef, which was detrimental for transport characteristics.
Effect of Solidification Cooling Rate on Microstructure and Mechanical Properties of an Extruded Mg-Zn-Y Alloy
Authors: Singh Alok , Osawa Yoshiaki , Somekawa Hidetoshi , Mukai Toshiji
Published: May 2018

The Effect of the solidification conditions and subsequent extrusion of a Mg-3.0Zn-0.5Y (at. %) alloy containing quasicrystalline icosahedral (i-) phase was studied. Solidification was carried out by three methods using a chill casting mold, a conventional steel mold and a water-cooled mold. Subsequently, castings were extruded in the temperature range of 235–270 ∘ C at an extrusion ratio of 25:1. The solidification molds showed different characteristics. The water-cooled mold was most effective in cooling through the walls, but least effective at the center of the mold. The conventional cast mold was the most effective in cooling at the mold center. All the castings had an interdendritic eutectic structure of the i-phase, and a supersaturation of the matrix in zinc. As a result, all the extrusions had similar grain size close to 1 μ m and very fine nano-size precipitation. Yield strengths in tension were in the range of 376 and 404 MPa, and from 300 to 330 MPa in compression. All elongations to fracture were about 13%. It is concluded that supersaturation of the matrix during solidification is the main factor, resulting in the dynamic precipitation of very fine precipitates and fine grain size during extrusion.
Hydrogen Embrittlement Mechanism in Fatigue Behavior of Austenitic and Martensitic Stainless Steels
Authors: Brück Sven , Schippl Volker , Schwarz Martina , Christ Hans-Jürgen , Fritzen Claus-Peter , Weihe Stefan
Published: May 2018

In the present study, the influence of hydrogen on the fatigue behavior of the high strength martensitic stainless steel X3CrNiMo13-4 and the metastable austenitic stainless steels X2Crni19-11 with various nickel contents was examined in the low and high cycle fatigue regime. The focus of the investigations were the changes in the mechanisms of short crack propagation. Experiments in laboratory air with uncharged and precharged specimen and uncharged specimen in pressurized hydrogen were carried out. The aim of the ongoing investigation was to determine and quantitatively describe the predominant processes of hydrogen embrittlement and their influence on the short fatigue crack morphology and crack growth rate. In addition, simulations were carried out on the short fatigue crack growth, in order to develop a detailed insight into the hydrogen embrittlement mechanisms relevant for cyclic loading conditions. It was found that a lower nickel content and a higher martensite content of the samples led to a higher susceptibility to hydrogen embrittlement. In addition, crack propagation and crack path could be simulated well with the simulation model.
Softening Characterization of 300M High-Strength Steel during Post-Dynamic Recrystallization
Authors: Zeng Rong , Huang Liang , Su Hongliang , Ma Huijuan , Ma Yangfei , Li Jianjun
Published: May 2018

This paper investigates softening phenomena within the post-dynamic recrystallization (PDRX) process in 300M high-strength steel specimens with different initial dynamically recrystallized volume fractions. Isothermal, interrupted compression experiments were performed on a Gleeble-3500 at a temperature of 1273 K and strain rate of 0.01 s−1. To acquire different initial volume fractions of dynamically recrystallized (DRX) grains, deformation was interrupted at two strain levels and immediately followed by isothermal annealing treatments. The softening behaviors respectively caused by the static recrystallization (SRX) and metadynamic recrystallization (MDRX) were qualitatively characterized by variations in the mechanical properties of the deformed and recrystallized grains. On the basis of the Taylor dislocation model, the evolution of geometric necessary dislocations (GNDs) and statistically stored dislocations (SSDs) densities were also discussed to qualitatively clarify the nature of different softening behaviors. Results indicate that the SRX occurred alone in samples without initial DRX grains, after an incubation time of approximately 50 s, while MDRX initially appeared within 1 s and completed at about 8 s in samples with a high initial volume fraction of DRX grains. The microhardness, indentation hardness, and Young’s modulus in the deformed and recrystallized grains decreased gradually with an increase of MDRX and SRX volume fractions. The sink-in and pile-up phenomena were enhanced by the SRX and MDRX softening processes, respectively. The SSDs density decreased more noticeably during the MDRX process than that during the SRX, which indicates that the MDRX process contributed to a more significant softening effect within the microstructural evolution regimes.
Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics
Authors: Blaženović Ivana , Kind Tobias , Ji Jian , Fiehn Oliver
Published: May 2018

The annotation of small molecules remains a major challenge in untargeted mass spectrometry-based metabolomics. We here critically discuss structured elucidation approaches and software that are designed to help during the annotation of unknown compounds. Only by elucidating unknown metabolites first is it possible to biologically interpret complex systems, to map compounds to pathways and to create reliable predictive metabolic models for translational and clinical research. These strategies include the construction and quality of tandem mass spectral databases such as the coalition of MassBank repositories and investigations of MS/MS matching confidence. We present in silico fragmentation tools such as MS-FINDER, CFM-ID, MetFrag, ChemDistiller and CSI:FingerID that can annotate compounds from existing structure databases and that have been used in the CASMI (critical assessment of small molecule identification) contests. Furthermore, the use of retention time models from liquid chromatography and the utility of collision cross-section modelling from ion mobility experiments are covered. Workflows and published examples of successfully annotated unknown compounds are included.
Electroosmotic Flow in Microchannel with Black Silicon Nanostructures
Authors: Lim An Eng , Lim Chun Yee , Lam Yee Cheong , Taboryski Rafael
Published: May 2018

Although electroosmotic flow (EOF) has been applied to drive fluid flow in microfluidic chips, some of the phenomena associated with it can adversely affect the performance of certain applications such as electrophoresis and ion preconcentration. To minimize the undesirable effects, EOF can be suppressed by polymer coatings or introduction of nanostructures. In this work, we presented a novel technique that employs the Dry Etching, Electroplating and Molding (DEEMO) process along with reactive ion etching (RIE), to fabricate microchannel with black silicon nanostructures (prolate hemispheroid-like structures). The effect of black silicon nanostructures on EOF was examined experimentally by current monitoring method, and numerically by finite element simulations. The experimental results showed that the EOF velocity was reduced by 13 ± 7%, which is reasonably close to the simulation results that predict a reduction of approximately 8%. EOF reduction is caused by the distortion of local electric field at the nanostructured surface. Numerical simulations show that the EOF velocity decreases with increasing nanostructure height or decreasing diameter. This reveals the potential of tuning the etching process parameters to generate nanostructures for better EOF suppression. The outcome of this investigation enhances the fundamental understanding of EOF behavior, with implications on the precise EOF control in devices utilizing nanostructured surfaces for chemical and biological analyses.
Functional Aspects of Fish Mucosal Lectins—Interaction with Non-Self
Authors: Brinchmann Monica Fengsrud , Patel Deepti Manjari , Pinto Nevil , Iversen Martin Haugmo
Published: May 2018

Mucosal surfaces are of key importance in protecting animals against external threats including pathogens. In the mucosal surfaces, host molecules interact with non-self to prevent infection and disease. Interestingly, both inhibition and stimulation of uptake hinder infection. In this review, the current knowledgebase on teleost mucosal lectins’ ability to interact with non-self is summarised with a focus on agglutination, growth inhibition, opsonisation, cell adhesion, and direct killing activities. Further research on lectins is essential, both to understand the immune system of fishes, since they rely more on the innate immune system than mammals, and also to explore these molecules’ antibiotic and antiparasitic activities against veterinary and human pathogens.
Liquid Marbles: From Industrial to Medical Applications
Authors: Avrămescu Roxana-Elena , Ghica Mihaela-Violeta , Dinu-Pîrvu Cristina , Udeanu Denisa Ioana , Popa Lăcrămioara
Published: May 2018

Liquid marbles are versatile structures demonstrating a pseudo-Leidenfrost wetting regime formed by encapsulating microscale volumes of liquid in a particle shell. The liquid core is completely separated from the exterior through air pockets. The external phase consists of hydrophobic particles, in most cases, or hydrophilic ones distributed as aggregates. Their interesting features arise from the double solid-fluid character. Thus, these interesting formations, also known as “dry waters”, have gained attention in surface science. This review paper summarizes a series of proposed formulations, fabrication techniques and properties, in correlation with already discovered and emerging applications. A short general review of the surface properties of powders (contact angle, superficial tension) is proposed, followed by a presentation of liquid marbles’ properties (superficial characteristics, elasticity, self-propulsion etc.). Finally, applications of liquid marbles are discussed, mainly as helpful and yet to be exploited structures in the pharmaceutical and medical field. Innovative pharmaceutical forms (Pickering emulsions) are also means of use taken into account as applications which need further investigation.
In Vitro Anticandidal Activity and Mechanism of a Polyoxovanadate Functionalized by Zn-Fluconazole Complexes
Authors: Guo Shuanli , Yang Wei , Zhao Mingming , Tian Rui , Zhang Boyu , Qi Yanfei
Published: May 2018

The rise in the number of fungal infections is requiring the rapid development of novel antifungal agents. A new polyoxovanadate functionalized by Zn-fluconazole coordination complexes, Zn3(FLC)6V10O28·10H2O (ZnFLC) (FLC = fluconazole) has been synthesized and evaluated for in vitro antifungal against Candida species. The identity of ZnFLC were confirmed by elemental analysis, IR spectrum, and single-crystal X-ray diffraction. The antifungal activities of ZnFLC was screened in 19 Candida species strains using the microdilution checkerboard technique. The minimum inhibitory concentration (MIC80) value of ZnFLC is 4 μg/mL on the azole-resistant clinical isolates of C. albicans HL973, which is lower than the positive control, FLC. The mechanism of ZnFLC against C. albicans HL973 showed that ZnFLC damaged the fungal cell membrane and reduced the ergosterol content. The expression of ERG1, ERG7, ERG11 ERG27, and ERG28, which have effects on the synthesis of ergosterol, were all significantly upregulated by ZnFLC.
Binding of Catechins to Staphylococcal Enterotoxin A
Authors: Shimamura Yuko , Utsumi Mio , Hirai Chikako , Nakano Shogo , Ito Sohei , Tsuji Ai , Ishii Takeshi , Hosoya Takahiro , Kan Toshiyuki , Ohashi Norio , Masuda Shuichi
Published: May 2018

Staphylococcal enterotoxin A (SEA) is a toxin protein, and is the most common cause of staphylococcal food poisoning. Polyphenols, such as catechins, are known to interact with proteins. In this study, we investigated the binding of catechins to SEA using SPR (Biacore), Fourier transform infrared spectroscopy (FT-IR), isothermal titration calorimetry (ITC), and protein-ligand docking. We found that (−)-epigallocatechin gallate (EGCG) could strongly bind to SEA. According to thermodynamic parameters, a negative ΔG indicated that the interaction between EGCG and SEA was spontaneous, and the electrostatic force accompanied by hydrophobic binding forces may play a major role in the binding. Data from Western blot analysis and docking simulation suggest that the hydroxyl group at position 3 of the galloyl group in the catechin structure was responsible for binding affinity with the Y91 of the A-6 region of SEA active sites. Our results provide further understanding of the binding interactions between catechins and SEA, and the inhibition of toxin activities by catechins.
Efficient Manipulation of Continuous AFI-Type Aluminophosphate Membranes with Distinctive Microstructures on Macroporous α-Al2O3 Substrates
Authors: Geng Luwei , Dong Hongfeng , Liu Xiufeng , Zhang Baoquan
Published: May 2018

The availability of continuous and well-defined AFI-type aluminophosphate membranes (AFI membranes) would trigger their applications in innovative materials. A well-designed manipulation strategy is proposed to produce continuous AFI membranes with four different microstructures over porous α-Al2O3 substrates. A double-layer and highly c-oriented AFI membrane of hexagonal prisms is obtained when a thin layer of medium molecular weight (MMW) chitosan is employed as the structure-directing matrix together with aluminum isopropoxide (AIP) as the Al source. It can be transformed to a single-layer and highly c-oriented AFI membrane of hexagonal prisms if the structure-directing matrix is replaced by a thin layer of low molecular weight (LMW) chitosan. When the Al source is changed to pseudo-boehmite, the single-layer AFI membrane is composed of highly ordered spherical agglomerates of small crystals. Furthermore, the membrane will turn to the double-layer AFI membrane of highly-ordered crystal agglomerates if a thin layer of MMW chitosan is used once again, keeping pseudo-boehmite as the Al source. The manipulation methodology established here is rather reliable with a pretty high reproducibility.
Unprecedented Fluorescent Dinuclear CoII and ZnII Coordination Compounds with a Symmetric Bis(salamo)-Like Tetraoxime
Authors: Zhang Lin-Wei , Liu Ling-Zhi , Wang Fei , Dong Wen-Kui
Published: May 2018

Two unprecedented homometallic CoII and ZnII coordination compounds, [M2(L)(OCH3)][M2(L)(OAc)] (MII = CoII (1) and ZnII (2)), with a novel symmetric bis(salamo)-like tetraoxime ligand H3L were synthesized and characterized by elemental analyses, infrafred (IR), ultraviolet–visible spectroscopy (UV-Vis), fluorescent spectra and single-crystal X-ray diffraction analyses. The unit cell of the two coordination compounds contains two crystallographically and chemically independent dinuclear coordination compounds. In the two coordination compounds, three metal ions are five-coordinated, formed two square pyramidal and a trigonal bipyramidal geometries, and the other metal ion is a hexacoordinate octahedral configuration. In addition, the coordination compound 1 forms a 3D supramolecular structure, and the coordination compound 2 forms a 0D dimer structure by the inter-molecular hydrogen bond interactions. Meanwhile, the fluorescence spectra of the coordination compounds 1 and 2 were also measured and discussed.
The Sucrose Synthase Gene Family in Chinese Pear (Pyrus bretschneideri Rehd.): Structure, Expression, and Evolution
Authors: Abdullah Muhammad , Cao Yungpeng , Cheng Xi , Meng Dandan , Chen Yu , Shakoor Awais , Gao Junshan , Cai Yongping
Published: May 2018

Sucrose synthase (SS) is a key enzyme involved in sucrose metabolism that is critical in plant growth and development, and particularly quality of the fruit. Sucrose synthase gene families have been identified and characterized in plants various plants such as tobacco, grape, rice, and Arabidopsis. However, there is still lack of detailed information about sucrose synthase gene in pear. In the present study, we performed a systematic analysis of the pear (Pyrus bretschneideri Rehd.) genome and reported 30 sucrose synthase genes. Subsequently, gene structure, phylogenetic relationship, chromosomal localization, gene duplications, promoter regions, collinearity, RNA-Seq data and qRT-PCR were conducted on these sucrose synthase genes. The transcript analysis revealed that 10 PbSSs genes (30%) were especially expressed in pear fruit development. Additionally, qRT-PCR analysis verified the RNA-seq data and shown that PbSS30, PbSS24, and PbSS15 have a potential role in the pear fruit development stages. This study provides important insights into the evolution of sucrose synthase gene family in pear and will provide assistance for further investigation of sucrose synthase genes functions in the process of fruit development, fruit quality and resistance to environmental stresses.
Graminex Pollen: Phenolic Pattern, Colorimetric Analysis and Protective Effects in Immortalized Prostate Cells (PC3) and Rat Prostate Challenged with LPS
Authors: Locatelli Marcello , Macchione Nicola , Ferrante Claudio , Chiavaroli Annalisa , Recinella Lucia , Carradori Simone , Zengin Gokhan , Cesa Stefania , Leporini Lidia , Leone Sheila , Brunetti Luigi , Menghini Luigi , Orlando Giustino
Published: May 2018

Prostatitis, a general term describing prostate inflammation, is a common disease that could be sustained by bacterial or non-bacterial infectious agents. The efficacy of herbal extracts with antioxidant and anti-inflammatory effects for blunting the burden of inflammation and oxidative stress, with possible improvements in clinical symptoms, is under investigation. Pollen extracts have been previously reported as promising agents in managing clinical symptoms related to prostatitis. The aim of the present work was to evaluate the protective effects of Graminex pollen (GraminexTM, Deshler, OH, USA), a commercially available product based on standardized pollen extracts, in rat prostate specimens, ex vivo. In this context, we studied the putative mechanism of action of pollen on multiple inflammatory pathways, including the reduction of prostaglandin E2 (PGE2), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), and malondialdehyde (MDA), whose activities were significantly increased by inflammatory stimuli. We characterized by means of chromatographic and colorimetric studies the composition of Graminex pollen to better correlate the activity of pollen on immortalized prostate cells (PC3), and in rat prostate specimens challenged with Escherichia coli lipopolysaccharide (LPS). We found that Graminex pollen was able to reduce radical oxygen species (ROS) production by PC3 cells and MDA, NFκB mRNA, and PGE2 levels, in rat prostate specimens. According to our experimental evidence, Graminex pollen appears to be a promising natural product for the management of the inflammatory components in the prostate.
Effect of Microwave Vacuum Drying on the Drying Characteristics, Color, Microstructure, and Antioxidant Activity of Green Coffee Beans
Authors: Dong Wenjiang , Cheng Ke , Hu Rongsuo , Chu Zhong , Zhao Jianping , Long Yuzhou
Published: May 2018

The aim of this study is to investigate the effect of microwave vacuum drying (MVD) on the drying characteristics and quality attributes of green coffee beans. We specifically focused on the effective moisture diffusion coefficient (Deff), surface temperature, glass transition temperature (Tg), water state, and microstructure. The kinetics of color changes during drying, total phenolic content (TPC), and antioxidant activity (DPPH, FRAP, and ABTS) were also characterized. Microwave power during MVD affected the porosity of coffee beans, their color, TPC, and antioxidant activity. The Allometric 1 model was the most suitable for simulating surface temperature rise kinetics. Thermal processing of green coffee beans resulted in increased b*, L*, ΔE, and TPC values, and greater antioxidant capacity. These findings may provide a theoretical reference for the technical improvement, mechanisms of flavor compound formation, and quality control of dried green coffee beans.
Implementation of Dietary Reference Intake Standards in Preschool Menus in Poland
Authors: Myszkowska-Ryciak Joanna , Harton Anna
Published: May 2018

Although the nutritional value of preschool menus largely determines the proper nutrition of attending children, their nutrient composition often does not meet the standards. The purpose of the study was to assess the nutritional value of menus served in preschools throughout Poland. We analyzed a sample of 10 daily menus and inventory reports reflecting foods and beverages served in 270 full-board government-sponsored preschools. Nutrient content was calculated per child per day, and compared with 70% of dietary reference intake (DRI) for children aged 1–3 and 4–6. The content of energy, protein, fat, and carbohydrates generally exceeded 70% of DRI. The amount of vitamins was correct, with the exception of vitamin D (100% of daycare centers (DCCs) were below the recommendations); in ≤3% of preschools vitamin E, folate, and niacin were below DRI. Calcium was too low in 63% of preschools for children aged 1–3 years and in 99% for 4–6-year-olds. A shortage of iodine, iron, and potassium (especially for 4–6-year-olds) was observed in a small number of preschools. Our study highlights the need for uniform legal standards of nutrition in childcare centers, based on the current recommendations for the age group.
Old Drugs as New Treatments for Neurodegenerative Diseases
Authors: Durães Fernando , Pinto Madalena , Sousa Emília
Published: May 2018

Neurodegenerative diseases are increasing in number, given that the general global population is becoming older. They manifest themselves through mechanisms that are not fully understood, in many cases, and impair memory, cognition and movement. Currently, no neurodegenerative disease is curable, and the treatments available only manage the symptoms or halt the progression of the disease. Therefore, there is an urgent need for new treatments for this kind of disease, since the World Health Organization has predicted that neurodegenerative diseases affecting motor function will become the second-most prevalent cause of death in the next 20 years. New therapies can come from three main sources: synthesis, natural products, and existing drugs. This last source is known as drug repurposing, which is the most advantageous, since the drug’s pharmacokinetic and pharmacodynamic profiles are already established, and the investment put into this strategy is not as significant as for the classic development of new drugs. There have been several studies on the potential of old drugs for the most relevant neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Multiple Sclerosis and Amyotrophic Lateral Sclerosis.
Reactive Energetic Plasticizers Utilizing Cu-Free Azide-Alkyne 1,3-Dipolar Cycloaddition for In-Situ Preparation of Poly(THF-co-GAP)-Based Polyurethane Energetic Binders
Authors: Ma Mingyang , Kwon Younghwan
Published: May 2018

Reactive energetic plasticizers (REPs) coupled with hydroxy-telechelic poly(glycidyl azide-co-tetrahydrofuran) (PGT)-based energetic polyurethane (PU) binders for use in solid propellants and plastic-bonded explosives (PBXs) were investigated. The generation of gem-dinitro REPs along with a terminal alkyne stemmed from a series of finely designed approaches to not only satisfy common demands as conventional energetic plasticizers, but also to prevent the migration of plasticizers. The miscibility and rheological behavior of a binary mixture of PGT/REP with various REP fractions were quantitatively determined by differential scanning calorimetry (DSC) and rheometer, respectively, highlighting the promising performance of REPs in the formulation process. The kinetics on the distinct reactivity of propargyl vs. 3-butynyl species of REPs towards the azide group of the PGT prepolymer in terms of Cu-free azide-alkyne 1,3-dipolar cycloaddition (1,3-DPCA) was studied by monitoring 1H nuclear magnetic resonance spectroscopy and analyzing the activation energies (Ea) obtained using DSC. The thermal stability of the finally cured energetic binders with the incorporation of REPs indicated that the thermal stability of the REP/PGT-based PUs was maintained independently of the REP content. The tensile strength and modulus of the PUs increased with an increase in the REP content. In addition, the energetic performance and sensitivity of REP and REP triazole species was predicted.
Recent Advances in Nanocellulose Composites with Polymers: A Guide for Choosing Partners and How to Incorporate Them
Authors: Chakrabarty Arindam , Teramoto Yoshikuni
Published: May 2018

In recent years, the research on nanocellulose composites with polymers has made significant contributions to the development of functional and sustainable materials. This review outlines the chemistry of the interaction between the nanocellulose and the polymer matrix, along with the extent of the reinforcement in their nanocomposites. In order to fabricate well-defined nanocomposites, the type of nanomaterial and the selection of the polymer matrix are always crucial from the viewpoint of polymer–filler compatibility for the desired reinforcement and specific application. In this review, recent articles on polymer/nanocellulose composites were taken into account to provide a clear understanding on how to use the surface functionalities of nanocellulose and to choose the polymer matrix in order to produce the nanocomposite. Here, we considered cellulose nanocrystal (CNC) and cellulose nanofiber (CNF) as the nanocellulosic materials. A brief discussion on their synthesis and properties was also incorporated. This review, overall, is a guide to help in designing polymer/nanocellulose composites through the utilization of nanocellulose properties and the selection of functional polymers, paving the way to specific polymer–filler interaction.
Diffractive and Interferometric Characterization of Nanostructured Photopolymer for Sharp Diffractive Optical Elements Recording
Authors: Fernández Roberto , Gallego Sergi , Tomita Yasuo , Pascual Inmaculada , Beléndez Augusto
Published: May 2018

We study the behavior of a nanoparticle-polymer composite (NPC) material, based on a thiol-ene monomer system, working with long grating spacing. Thus, we evaluate the suitability of the NPC for storing complex diffractive optical elements with sharp profiles, such as blazed gratings. Using holographic methods, we measure the “apparent” diffusion of the material and the influence of the spatial period on this diffusion. The applicability of this material in complex diffractive optical elements (DOEs) recording is analyzed using an interferometric method. Supported by the results of this analysis, we record blazed gratings with different grating spacing and measure the maximum diffraction efficiency (DE) achieved. The results show that NPC has a good behavior in this range of spatial frequencies.
A Systematic Framework for Data Management and Integration in a Continuous Pharmaceutical Manufacturing Processing Line
Authors: Cao Huiyi , Mushnoori Srinivas , Higgins Barry , Kollipara Chandrasekhar , Fermier Adam , Hausner Douglas , Jha Shantenu , Singh Ravendra , Ierapetritou Marianthi , Ramachandran Rohit
Published: May 2018

As the pharmaceutical industry seeks more efficient methods for the production of higher value therapeutics, the associated data analysis, data visualization, and predictive modeling require dependable data origination, management, transfer, and integration. As a result, the management and integration of data in a consistent, organized, and reliable manner is a big challenge for the pharmaceutical industry. In this work, an ontological information infrastructure is developed to integrate data within manufacturing plants and analytical laboratories. The ANSI/ISA-88.01 batch control standard has been adapted in this study to deliver a well-defined data structure that will improve the data communication inside the system architecture for continuous processing. All the detailed information of the lab-based experiment and process manufacturing, including equipment, samples and parameters, are documented in the recipe. This recipe model is implemented into a process control system (PCS), data historian, as well as Electronic Laboratory Notebook (ELN) system. Data existing in the recipe can be eventually exported from this system to cloud storage, which could provide a reliable and consistent data source for data visualization, data analysis, or process modeling.
Spiritual and Religious Issues in the Aftermath of Suicide
Authors: Dransart Dolores Angela Castelli
Published: May 2018

Introduction: Spirituality and religion have only been marginally investigated in the experiences of the bereaved by suicide (or survivors of suicide). Aim: This article directly addresses two questions: In what way was spirituality or religion an issue for survivors of suicide? How were they helpful (or not) during their reconstruction process? Method: Research involved qualitative studies, carried out in Switzerland with 50 survivors of suicide using in depth-interviews. Data were analyzed according to grounded theory principles. Results: Suicide triggered questioning mainly about the afterlife of the deceased and of how transcendency relates to agency and responsibility in the suicidal act. Spiritual or religious issues play an important role in the process of reconstruction for survivors, notably in meaning-making and responsibility-clarifying processes, in forging a continuing bond with the deceased and in honoring their life and memory. Nevertheless, this role is complex and can either support or make the recovery difficult (or both). Conclusion: Mental health and social care professionals may support survivors’ resilience and their reconstruction process by valuing the constructive aspects of their spiritual and religious experiences and by taking into account the spiritual and religious struggles they face to offer effective support to survivors of suicide during recovery.
Multi-Layered Roles of Religion among Refugees Arriving in Austria around 2015
Authors: Buber-Ennser Isabella , Goujon Anne , Kohlenberger Judith , Rengs Bernhard
Published: May 2018

Violent conflicts and social unrest in the Middle East, in Central Asia, and in Africa have led to growing numbers of persons seeking refuge in Europe since 2011. The phenomenon culminated in 2015. In that year, with 88,300 new asylum applications, Austria was the 4th largest receiver of asylum seekers in the EU, thereby increasing visibly religious diversity in the country. Using two social surveys carried out in 2015 and in 2017 among asylum seekers and refugees, we study religious affiliation, religiosity, and attitudes as well as participation in religious groups. By focusing on the time span shortly after arriving in Austria, we aim to shed light on first steps in the host society and the multi-layered roles of religion for participation and integration. We provide a comparison with the host society in terms of religious affiliation and religiosity, and discuss recent qualitative research on refugees and religiosity. Insights into the engagement of refugees in several activities related to religion or not are valuable to shed light on the multi-layered characteristics of the recent inflow of forced migrants in Austria.
Modeling the Distributions of Brightness Temperatures of a Cropland Study Area Using a Model that Combines Fast Radiosity and Energy Budget Methods
Authors: Bian Zunjian , Cao Biao , Li Hua , Du Yongming , Huang Huaguo , Xiao Qing , Liu Qinhuo
Published: May 2018

Land surface temperatures (LSTs) obtained from remote sensing data are crucial in monitoring the conditions of crops and urban heat islands. However, since retrieved LSTs represent only the average temperature states of pixels, the distributions of temperatures within individual pixels remain unknown. Such data cannot satisfy the requirements of applications such as precision agriculture. Therefore, in this paper, we propose a model that combines a fast radiosity model, the Radiosity Applicable to Porous IndiviDual Objects (RAPID) model, and energy budget methods to dynamically simulate brightness temperatures (BTs) over complex surfaces. This model represents a model-based tool that can be used to estimate temperature distributions using fine-scale visible as well as near-infrared (VNIR) data and temporal variations in meteorological conditions. The proposed model is tested over a study area in an artificial oasis in Northwestern China. The simulated BTs agree well with those measured with the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER). The results reflect root mean squared errors (RMSEs) less than 1.6 °C and coefficients of determination (R2) greater than 0.7. In addition, compared to the leaf area index (LAI), this model displays high sensitivity to wind speed during validation. Although simplifications may be adopted for use in specific simulations, this proposed model can be used to support in situ measurements and to provide reference data over heterogeneous vegetation surfaces.
Assessment of Scattering Error Correction Techniques for AC-S Meter in a Tropical Eutrophic Reservoir
Authors: Watanabe Fernanda , Rodrigues Thanan , Do Carmo Alisson , Alcântara Enner , Shimabukuro Milton , Imai Nilton , Bernardo Nariane , Rotta Luiz Henrique
Published: May 2018

Measurements of absorption coefficients (a(λ), in m−1) collected by spectrophotometers in situ are overestimated due to the scattering of the reflecting tube absorption meter. Accurate correction of these data is essential in order to characterize water bodies bio-optically, as well as retrieve the remote sensing reflectance (Rrs, in sr−1), when applying a forward model. There are various methods of scattering error correction; however, they were all developed for clear water. In this research, different techniques were attempted in order to define the most appropriate method for correcting a(λ) values acquired by an absorption and attenuation spectral (ac-s) meter (WET Labs Inc., Philomath, OR, USA) in a tropical eutrophic reservoir. Three methods recommended by the manufacturer of the ac-s meter were tested: “flat” or “baseline”, “constant fraction”, and “proportional”. These methods were applied to two datasets that were measured in May and October 2014. The flat technique exhibited the lowest errors, with an average normalized root mean square error (NRMSE) of 7.95%, and a mean absolute percentage error (MAPE) of 29.26% for May. Meanwhile, proportional was the most suitable technique for most of the samples in October, with a mean NRMSE of 11.19% and a MAPE of 31.03% for October. In addition, the proportional method maintained the shape of the a(λ) values better than the other methods. Despite that, both the flat and proportional methods gave a similar performance statistically. Moreover, the flat method produced the best estimations of chla content for both datasets. Therefore, this method is recommended to correct ac-s data in retrieving such phytoplankton pigments.
Investigation of Grating-Assisted Trimodal Interferometer Biosensors Based on a Polymer Platform
Authors: Liang Yuxin , Zhao Mingshan , Wu Zhenlin , Morthier Geert
Published: May 2018

A grating-assisted trimodal interferometer biosensor is proposed and numerically analyzed. A long period grating coupler, for adjusting the power between the fundamental mode and the second higher order mode, is investigated, and is shown to act as a conventional directional coupler for adjusting the power between the two arms. The trimodal interferometer can achieve maximal fringe visibility when the powers of the two modes are adjusted to the same value by the grating coupler, which means that a better limit of detection can be expected. In addition, the second higher order mode typically has a larger evanescent tail than the first higher order mode in bimodal interferometers, resulting in a higher sensitivity of the trimodal interferometer. The influence of fabrication tolerances on the performance of the designed interferometer is also investigated. The power difference between the two modes shows inertia to the fill factor of the grating, but high sensitivity to the modulation depth. Finally, a 2050 2π/RIU (refractive index unit) sensitivity and 43 dB extinction ratio of the output power are achieved.
An RFID Indoor Positioning Algorithm Based on Support Vector Regression
Authors: Xu He , Wu Manxing , Li Peng , Zhu Feng , Wang Ruchuan
Published: May 2018

Nowadays, location-based services, which include services to identify the location of a person or an object, have many uses in social life. Though traditional GPS positioning can provide high quality positioning services in outdoor environments, due to the shielding of buildings and the interference of indoor environments, researchers and enterprises have paid more attention to how to perform high precision indoor positioning. There are many indoor positioning technologies, such as WiFi, Bluetooth, UWB and RFID. RFID positioning technology is favored by researchers because of its lower cost and higher accuracy. One of the methods that is applied to indoor positioning is the LANDMARC algorithm, which uses RFID tags and readers to implement an Indoor Positioning System (IPS). However, the accuracy of the LANDMARC positioning algorithm relies on the density of reference tags and the performance of RFID readers. In this paper, we introduce the weighted path length and support vector regression algorithm to improve the positioning precision of LANDMARC. The results show that the proposed algorithm is effective.