bluuebunny/crossref_metadata_2025 huggingface dataset:
Selective Targeting of Breast Cancer by Tafuramycin A Using SMA-Nanoassemblies
Authors: El-Deeb Ibrahim M. , Pittala Valeria , Eltayeb Diab , Greish Khaled
Published: June 2021

Triple-negative breast cancer (TNBC) is a heterogeneous subtype of tumors that tests negative for estrogen receptors, progesterone receptors, and excess HER2 protein. The mainstay of treatment remains chemotherapy, but the therapeutic outcome remains inadequate. This paper investigates the potential of a duocarmycin derivative, tafuramycin A (TFA), as a new and more effective chemotherapy agent in TNBC treatment. To this extent, we optimized the chemical synthesis of TFA, and we encapsulated TFA in a micellar system to reduce side effects and increase tumor accumulation. In vitro and in vivo studies suggest that both TFA and SMA–TFA possess high anticancer effects in TNBC models. Finally, the encapsulation of TFA offered a preferential avenue to tumor accumulation by increasing its concentration at the tumor tissues by around four times in comparison with the free drug. Overall, the results provide a new potential strategy useful for TNBC treatment.
A Comprehensive Review of Almond Clinical Trials on Weight Measures, Metabolic Health Biomarkers and Outcomes, and the Gut Microbiota
Authors: Dreher Mark L.
Published: June 2021

This comprehensive narrative review of 64 randomized controlled trials (RCTs) and 14 systematic reviews and/or meta-analyses provides an in-depth analysis of the effect of almonds on weight measures, metabolic health biomarkers and outcomes, and the colonic microbiota, with extensive use of figures and tables. Almonds are a higher energy-dense (ED) food that acts like a lower ED food when consumed. Recent systematic reviews and meta-analyses of nut RCTs showed that almonds were the only nut that had a small but significant decrease in both mean body mass and fat mass, compared to control diets. The biological mechanisms for almond weight control include enhanced displacement of other foods, decreased macronutrient bioavailability for a lower net metabolizable energy (ME), upregulation of acute signals for reduced hunger, and elevated satiety and increased resting energy expenditure. The intake of 42.5 g/day of almonds significantly lowered low-density lipoprotein cholesterol (LDL-C), 10-year Framingham estimated coronary heart disease (CHD) risk and associated cardiovascular disease (CVD) medical expenditures. Diastolic blood pressure (BP) was modestly but significantly lowered when almonds were consumed at >42.5 g/day or for >6 weeks. Recent RCTs suggest possible emerging health benefits for almonds such as enhanced cognitive performance, improved heart rate variability under mental stress, and reduced rate of facial skin aging from exposure to ultraviolet (UV) B radiation. Eight RCTs show that almonds can support colonic microbiota health by promoting microflora richness and diversity, increasing the ratio of symbiotic to pathogenic microflora, and concentrations of health-promoting colonic bioactives. Almonds are a premier healthy snack for precision nutrition diet plans.
In the development of management accounting of livestock products dairy activities in agricultural organizations
Authors: Yusufov Abdulkadir Myrzagaliyevich , Aminat Musaeva Mustafaeva , Orujov Zamira Abdulgazieva
Published: June 2021

The article presents arguments on the economic feasibility of taking into account the increase in the live weight of productive livestock of the main dairy herd. The problem of its definition, accounting support and registration, as well as the regulation on this basis of the book value of animals of the main herd, remains unsolved for the agricultural economy until now. It has a large inexhaustible reserve at the current stage of economic development, on the basis of which it is possible to find fair opportunities for establishing objective rates of economic growth. Studies have shown that agricultural organizations in the dairy sector do not yet take into account all products received from productive livestock of the main dairy herd. In this direction of development, the state of increase in the live weight of the main herd of cattle is not recorded in the accounting. In order to justify this, calculations based on the reporting data of agricultural organizations of the Republic of Dagestan for 2008-2018 are presented. The expediency of taking into account and evaluating the resulting increase in live weight is proved in order not only to correctly calculate the cost of production, objectively distributing the costs between the main and associated types of products from the dairy herd of productive cattle (milk and offspring), but also for the growth of the value of the equity of the economic entity
Depreciation of fixed assets in agricultural organizations: innovations in the context of the transition to FSBU 6/2020
Authors: Khairullina Olga Ivanovna , Ryzhkova Anastasia Nikolaevna
Published: June 2021

In this article, depreciation is considered as a key element of innovation. It was found that the changes made by FSBU 6/2020 “Fixed Assets” affected all the key parameters for calculating depreciation: the initial cost of objects, useful life, subsequent assessment, methods of calculating depreciation. The options are proposed for making adjustments to the accounting policy, the advantages and disadvantages of possible options for calculating depreciation are identified. Transition options to the new standard are recommended.
Features of agriculture and their impact on the organization and methodology of inter-organizational management accounting
Authors: Khoruzhy Lyudmila Ivanovna , Katkov Yury Nikolaevich , Katkova Ekaterina Alekseevna , Romanova Anastasiya Alekseevna
Published: June 2021

The article proposes a list of features of inter-organizational management accounting for agricultural organizations. The specifics of management accounting of agricultural enterprises were considered and ways to solve problems of accounting adaptation were found. A structural chart of a management accounting account is proposed to reflect operations in inter-organizational interaction. Method of functioning of inter-organizational accounting system in automated environment is disclosed. A business process card for the type of activity «Production of crop products» has been developed and described. On the example of agricultural enterprises, examples are given of the reflection in the interorganizational management accounting of the facts of the economic life of partners, taking into account the peculiarities of the functioning of agrosphere enterprises.
Analysis of income of agricultural producers during the implementation of state programs for the development of agriculture
Authors: Romantseva Julia Nikolaevna , Khudyakova Elena Viktorovna , Butyrin Vasilij Vladimirovich , Galyautdinova Dinara Farhatovna
Published: June 2021

The aim of the research is to study the dynamics of the size, structure and features of the formation of incomes of agricultural producers during the implementation of state programs for the development of agriculture. Based on the analysis of the main periods of income generation, from 2006, it was concluded that economic sanctions contributed to the strengthening of the industry’s position and the stable growth of gross value added for economic activity “Agriculture, forestry, hunting, fishing and fish farming”. As a result of studying the formation of gross value added, a significant decrease in the efficiency of material costs in the agricultural sector was noted due to the persisting price disparity. The analysis of the composition and structure of gross value added made it possible to identify positive trends in wages and confirm the process of enlarging production in the agricultural sector. A study of the main commodity producers — agricultural organizations and peasant (farmer) households — showed that with a greater level of state support for the large-scale sector, the profitability of farmers is higher. In general, the development of the industry has a high rate, which gives rise to favorable forecasts for the achievement of key indicators of the State Program for the Development of Agriculture and the regulation of markets for agricultural products, raw materials and food.
PASSIVE SAFETY OF MOTOR TRANSPORT DEPENDING ON THE
Authors:   Voronezh State Forestry Engineering University, BELOKUROV V.P. , BUSARIN E.N. ,   Voronezh State Forestry Engineering University, KORABLEV R.A. ,   Voronezh State Forestry Engineering University, SPODAREV R.A. ,   Voronezh State Forestry Engineering University
Published: June 2021

The interrelation of thermal modes of brake units of transport vehicles on their reliability and durability depending on operational factors of transport is considered. It is assumed that all the kinetic energy of rotating and translationally moving masses in the brake nodes is converted into thermal energy. In this regard, a criterion is used that characterizes the thermal energy released in the brakes and the operational criterion of transport vehicles. Comparison of these criteria makes it possible to evaluate the performance and durability of brake components, as well as to outline ways of their structural perfection depending on heat dissipation.
IMPROVING THE ACCURACY OF DETERMINING THE FREQUENCY
Authors:   Academy of the Federal security service of the Russian Federation, SAVIN L.O.
Published: June 2021

The paper substantiates a method for increasing the accuracy of determining the optimal fre-quency of maintenance of one of the most important units of automotive equipment operating in various climatic and road transport conditions - its engines, and also presents circuit proposals for the implementation of this method. The proposed approach makes it possible to significantly increase the accuracy of determining the optimal frequency of maintenance of internal combustion engines by taking into account their real technical condition when operating in different (different from the average) operating conditions. The article provides typical examples of calculating the determination of the optimal frequency of maintenance of automotive equipment, and also estimates the gain achieved when using the approach proposed in the work.
MODEL OF THE DRIVER'S PERCEPTION OF THE ROAD SITUATION AT THE INITIAL STAGE OF PREPARATION
Authors:   South-West State University, AGEEV E.V. , NOVIKOV A.N. ,   Orel State University, VINOGRADOV E.S. ,   South-West State University
Published: June 2021

This article analyzes the requirements for drivers, taking into account their professional activities. The model of the driver's perception of the road situation when driving a car in real time is considered. The purpose of this work is to prepare candidates for drivers for safe, confident driving. The paper suggests the author's method of training candidates for drivers at the initial stage of training.
«E io sono in quel numero, benché disutile sia»: l’amicizia tra Lapo Mazzei e Francesco Datini
Authors: Camesasca Gloria
Published: June 2021

Il notaio Lapo Mazzei (1350-1412) era un corrispondente del mercante pratese Francesco di Marco Datini (1335 circa-1410). Le lettere di Mazzei scritte a Datini dal 1390 al 1410 e pubblicate da Cesare Guasti (1822-1889) sono una fonte importante perché restituiscono uno spaccato significativo della vita e dei rapporti personali di un mercante e di un notaio vissuti in Toscana alla fine del XIV secolo. Lo scopo di questo lavoro è analizzare l'amicizia tra Mazzei e Datini e altre figure importanti attraverso lo studio delle lettere notarili
Application of infrared spectrometry in forensic practice of the Institute of Forensic Research – memoirs of a retired forensic expert
Authors:   Retired expert witness of the Institute of Forensic Research, Cracow (Poland), Trzcińska Beata
Published: June 2021

The Authoress of the hereby paper, now a retired expert in expert in chemistry of the Institute of Forensic Research in Cracow, Poland has used IR spectrometry throughout past thirty years both in examinations made for research schemes and during forensic examinations requested by judicial authorities. That method has always been combined with optical examinations. The hereby paper constitutes a review of selected cases that demonstrate not only the value of IR spectrometry in forensic identification or comparative examinations but also its usefulness in the analysis of such aspects as the influence of a background or complexity of the submitted material.
La organización de la violencia militar en el siglo XXI
Authors: Malešević Siniša
Published: June 2021

El artículo analiza las bases sociológicas de la violencia militar en el siglo XXI. En la primera parte, se debaten críticamente los tres enfoques contemporáneos que son dominantes en la explicación de la violencia organizada: a) la perspectiva del declive de la violencia, b) el enfoque de las “nuevas guerras” y c) la aproximación del desplazamiento tecnológico. Se sostiene que, a pesar de sus indiscutibles fortalezas, estas perspectivas no proporcionan una interpretación adecuada de los cambios sociales contemporáneos. En particular, se cuestiona su énfasis en la ruptura radical en el carácter de la violencia militar contemporánea en comparación con otros periodos históricos. En la segunda parte el artículo se desarrolla una visión alternativa, sociológica y de larga duración, centrada en el papel de los poderes coercitivos, ideológicos y micro-interactivos en la transformación de la violencia militar. En oposición a las tres perspectivas dominantes, se argumenta que la violencia organizada en el siglo XXI se ha transformado pero exhibe aún mucha más continuidad con los tres últimos siglos de lo que se viene asumiendo. Concretamente, se enfatiza el impacto a largo plazo de tres procesos históricos que han dado forma a la dinámica de la violencia militar: la burocratización acumulativa de la coerción, la ideologización centrífuga y el envolvimiento de micro-solidaridades.
Mujeres, diversidad y medios de comunicación en Argentina. Informe
Authors: Capitini Marina , Bustamante Hoffmann Eugenia , García Marianela
Published: June 2021

Este nuevo trabajo del Observatorio busca dar cuenta y reponer debates políticos actuales que se han posicionado en la agenda pública y arribado al terreno legislativo. El interés radica en sus dimensiones epistemológicas vertebradoras, la paridad y su traducción en los medios y el género como categoría relacional ubicua que se centra en relaciones de poder invisibles e invisibilizadas. La regulación de esta estentórea desigualdad, pretende incidir en los ámbitos laborales para abrir accesos a espacios hasta el moment vedados a mujeres y LGTBI+, y poder, desde allí, provocar deslizamientos en las estructuras de sentido. Estas desigualdades han sido relevadas en los Informes que año tras año se han realizado los equipos de la Defensoría del Público con persistencia y a pesar de los tiempos de neoliberalismo en los que intentaron barrer con toda posibilidad de reconocimiento de derechos. Otra fuente de información que nos ha revelado esta situación es el Informe Global de Medios que se realiza desde 1995. Esta avanzada en pos de una democracia que dé cuenta de los derechos ciudadanos, nos propone algunos interrogantes ¿qué significa la paridad y por qué es necesaria? ¿esa paridad es vertical y horizontal, es decir, cala en las presencias materializadas en programas y secciones pero también en las representaciones laborales jerárquicas? ¿cuál es la posibilidad que una política pública que abogue por la paridad conmueva también la producción y enunciación de contenidos en los medios?. Como toda política pública, requiere además de la identificación del problema, de la solidez del argumento del diagnóstico y su tramitación en proyecto y gestión, etapas de evaluación que nos permitirán saber, en el correr de su implementación, si hemos podido conmover el poder arraigado de sentidos arcaicos. En suma, si hemos podido responder a la imperiosa necesidad de vencer la violencia simbólica, y efectuar desplazamientos de sentidos que superen los estereotipos y el sexismo en sus diversas formas. Por lo pronto la experiencia del cupo en Argentina, sostenida por una militancia incansable, y más tarde la reciente paridad en las listas electorales, han significado la posibilidad del acceso de las mujeres a la esfera por definición histórica, más masculinizada y masculina, la del poder político público. Paridad es la igualdad de las partes. En un mundo profundamente desigual, con medios altamente concentrados, esta apuesta cobra mayor volumen. Desafía en inscribirse desde un estatuto de lo legal, en la materialidad de una comunicación que se plantea como derecho humano.
Analisis Kepemimpinan Kepala Sekolah, Penerapan Disiplin dan Pengawasan Terhadap Etos Kerja
Authors: Suyitno
Published: June 2021

Work ethic is a fundamental trait and individual way of giving expression to work that can be a driving force or driving force for success. A teacher who has a high work ethic tends to have a positive attitude towards his job. This study investigates the principal’s leadership, implementation of discipline, and supervision on work ethic of teacher’s in the Public Senior High School at Tulungagung Regency. Data were collected from 244 respondents using questionnaire, interview and document and used SPSS 17.0 for analysis on multiple regression, F-test and t-test. The findings showed the significant effects existed between (1) the principal leadership (X1) on work ethic of teacher (Y) r = 0.532; p = .000; (2) implementation of discipline (X2) on the work ethic of teacher (Y) r = 0.301; p = .013; (3) the supervision (X3) on the work ethic of teacher (Y) r = 0.344; p = .005; and (4) the principal leadership (X 1), implementation of discipline (X2), and the supervision (X3) to the work ethic of teacher simultaneously at Rsquare = 0.605; p = .000. Principal’s leadership, discipline implementation and supervision have a significant effect on teacher work ethic. Among the three independent variables, the principal's leadership variable has a dominant influence on the work ethic of the teacher.
PEMBELAJARAN IPS BERBASIS KEARIFAN LOKAL SEBAGAI PEMBENTUK PENDIDIKAN KARAKTER DI SEKOLAH
Authors: nurhikmah
Published: June 2021

AbstrakSeiring berkembangnya zaman, kita semua dituntut untuk mampu untuk menjawab semua tantangan yang ada. Melalui pendidikan, kita kita memiliki kekuatan untuk menjawab tantangan tersebut. Dengan adanya pendidikan berbasis kearifan lokal, yang mana di dalam kearifan lokal terdapat pendidikan karakter didalannya dan sebagai satu diantara sumber nilai moral yang baik. Kearifan lokal terdiri dari nilai-nilai yang dinggap baik oleh suatu masyrakat tertentu yang mereka jadikan sebagai pedoman untuk mengatur pola perilaku di tengah masyarakat. Maka dari itu, pendidik harus mampu merancang pembelajaran yang memuat kearifan lokal yang ada di lingkungan peserta didik. Dari pembelajaran yang mengaitkan dengan kearifan lokal, dapat menciptakan pembelajaran yang bermakna untuk peserta didik.
Relevance of Parasitological Research in the South of the Russian Far East
Authors: Voronova AN , Tabakaeva TV , Vainutis KS , Tabakaev AV , Galkina IV
Published: June 2021

Background: The south of the Russian Far East including the Amur Region, the Jewish Autonomous Region, the Khabarovsk and Primorsky Regions is a unique area in terms of richness of the parasite fauna. Historically, ideal conditions for the existence of various foci of parasitic infections have formed locally. The objective of our study was to provide a brief description of the history of parasitological studies conducted in the south of the Russian Far East since the first half of the 20th century and to demonstrate their relevance. Materials and methods: We analyzed appropriate literary sources found in the Web of Science, PubMed, Scopus, Elsevier, Springer, and Google Scholar databases. Results: We established that the species diversity of trematodes was studied better than that of cestodes, nematodes, higher and lower monogeneans. The accumulated knowledge is fundamental for understanding distribution and pathogenicity of helminths. However, contemporary parasitological research is characterized by a high level of interdisciplinarity and integration. A simple systematization of parasites is no longer enough; it is necessary to characterize molecular mechanisms underlying pathogenesis, antigenic variability, and drug resistance. The article discusses perspectives of future parasitological research of the biology of endo- and ectoparasites, host–parasite interactions and links at different levels of organization: biocenotic, population and organismic, complementing theoretical data on the processes of microevolution and coevolution of the pathogen and the host. Conclusion: Existing problems can be solved using proteomic, genomic, transcriptomic, and bioinformatics approaches that contribute to a better understanding of the biology of objects and are promising for identification of clinically important biological characteristics of parasitic organisms.
Implementasi Kebijakan Diskresi Pada Pelayanan Kesehatan Badan Penyelenggara Jaminan Kesehatan (BPJS)
Authors: Suprapto Suprapto , Malik Andi Abdul
Published: June 2021

Diskresi birokrasi dalam pemerintahan daerah sebagai salah satu upaya efektivitas pelayanan publik diterbitkannya dalam keadaan mendesak yaitu suatu keadaan yang muncul secara tiba-tiba menyangkut kepentingan umum yang harus diselesaikan dengan cepat, dimana untuk menyelesaikan persoalan tersebut, peraturan perundang-undangan belum mengaturnya.Kendala-kendala di dalam diskresi birokrasi dalam pemerintahan daerah sebagai salah satu upaya efektivitas pelayanan publik adalah biaya yang tidak mencukupi akibat permintaan yang berlebihan dari program diskresi birokrasi, peserta kebijakan yang membengkak tidak sesuai dengan rencana yang telah ditetapkan misalnya peserta yang sebenarnya tidak dikategorikan miskin tetapi meminta diklasifikasikan sebagai keluarga miskin dan pelayanan administratif yang tidak lancar karena kebijakan diskresi birokrasi lebih merupakan program spontanitas dari pemerintah daerah.Model diskresi yang ideal untuk mengatasi masalah pelimpahan wewenang yang terjadi selama ini adalah memberikan pelatihan kompetensi tambahan tindakan medik kepada perawat dengan tujuan perawat mampu memberikan pelayanan tindakan medik terbatas sesuai dengan tugas dan wewenang yang tercantum dalam UU Keperawatan.Dalam perkembangan ilmu adminsitrasi publik begitu banyak dinamika yang timbul, mulai dari peran dari administrasi publik yang terpisah sama sekali dengan dunia politik. Pemahaman selanjutnya yang kemudian muncul bahwa adminsitrasi itu adalah bagian dari politik. Paradigma yang muncul adalah “when politic ends administration begins”. Pemahaman-pemahaman inilah yang kemudian memunculkan banyak pendapat baik dari kalangan ilmuwan ataupun praktisi untuk menggali kembali esensi dari ilmu administrasi publik.Pemerintah Daerah perlu melakukan tindakan hukum diskresi (freies ermessen) untuk yang berada di daerah terpencil ataupun di pedesaan. Diskresi tersebut merupakan segala aktifitas yang melibatkan proses pembuat kebijakan maupun pengambilan kepututusan atau tindakan atas inisiatif sendiri, tidak terpaku pada ketentuan aturan atau undang-undang dengan berbagai pertimbangan yang matang, konstektual dan dapat dipertanggungjawabkan
FISHBONE ANALYSIS SEBAGAI METODE DALAM PENCEGAHAN KECELAKAAN LALU LINTAS
Authors: Dahlan Maarifah , Sukmawati Sukmawati , Irdan Muhammad
Published: June 2021

Kecelakaan lalu lintas di jalan merupakan salah satu penyumbang angka kematian nomor satu di dunia. Sekitar 3.400 orang meninggal dunia di jalan setiap hari tidak terkecuali di Kecamatan Matakali dengan angka kejadian kecelakaan mencapai 862 kasus sejak tahun 2016-2019. Penelitian ini bertujuan untuk mengidentifikasi penyebab dasar kecelakaan lalu lintas agar dapat dilakukan upaya pencegahan di masa yang akan dating. Penelitian ini merupakan penelitian kualitatif dengan pendekatan studi kasus yang terdiri atas responden kunci dan utama dengan teknik snowball sampling, data dikumpulkan melalui wawancara mendalam, dokumentasi, dan observasi. Analisis data dilakukan dengan menggunakan model analisis editing. Adapun hasil analisis menunjukkan bahwa penyebab dasar kecelakaan lalu lintas disebabkan karena kurangnya kesadaran pengendara terhadap persyaratan dan prosedur keselamatan pengendara dan pengawasan dari pihak kepolisian terhadap pelanggaran terhadap prosedur keselamatan pengendara. Disarankan kepada pemerintah dalam hal ini pihak Kepolisian Polres Polewali Mandar agar kiranya dapat membentuk membuat program Behaviour Based Safety/budaya K3 kepada masyarakat sebagai bentuk upaya pencegahan terhadap risiko kecelakaan lalu lintas.
DETERMINAN PERNIKAHAN USIA MUDA DI KABUPATEN POLEWALI MANDAR
Authors: Raehan Raehan , Sitti Aras Diana  , Wahida Munir
Published: June 2021

Indonesia merupakan negara berkembang yang termasuk negara dengan persentase pernikahan usia dini tinggi di dunia. Pernikahan dini pada remaja merupakan salah satu masalah kesehatan reproduksi remaja dan memiliki lebih banyak implikasi negatif terhadap kelangsungan hidup remaja. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang berhubungan dengan kejadian pernikahan usia muda di Kabupaten Polewali Mandar tahun 2019. Dengan menggunakan desain penelitian cross sectional dengan pendekatan kuantitatif. Hasil penelitian menunjukkan ada pengaruh yang signifikan antara pengetahuan responden terhadap kejadian pernikahan  Usia Muda. Ada pengaruh antara pendidikan, pengetahuan, ekonomi responden terhadap kejadian pernikahan dini. Diharapakan  untuk lebih meningkatkan penidikan kesehatan bagi remaja dan orang tuanya tentang bahanyanya melakukan pernikahan dini bagi kesehatan maupun masa depan bagi remaja itu sendiri.
PERILAKU IBU DALAM STIMULASI TUMBUH KEMBANG BALITA USIA 0-6 BULAN SETELAH PEMBERIAN ANTICIPATORY GUIDANCE
Authors: Trianita Desi , Wilujeng Atik Pramesti , Indriyani Ninis
Published: June 2021

Periode balita adalah periode tumbuh kembang yang pesat dimana anak mencapai perkembangan yang optimal pada usia ini. Keluarga terutama ibu adalah pihak yang memiliki peran penting dalam mengoptimalkan tumbuh kembang anak. Penelitian ini bertujuan menganalisis perbedaan perilaku ibu dalam memberikan stimulasi tumbuh kembang setelah diberikan anticipatory guidance dengan kelompok ibu yang tidak diberikan anticipatory guidance. Desain penelitian ini menggunakan quasy experimental post test only non equivalent control group sedangkan sampelnya adalah ibu-ibu yang memiliki bayi usia 0-6 bulan sebanyak 54 orang yang diambil dengan tehnik purposive sampling. Hasil uji statistik U Mann-Whitney menunjukkan bahwa terdapat perbedaan perilaku ibu dalam memberikan stimulasi tumbuh kembang pada kelompok perlakuan dengan kelompok kontrol dengan nilai ρ = 0,000. Penilaian perilaku ibu dalam memberikan stimulasi tumbuh kembang dilakukan dengan melakukan pengisian kuesioner Anticipatory guidance  merupakan pemberian bimbingan dan pendampingan oleh tenaga kesehatan kepada orang tua anak dalam hal ini adalah ibu mengenai bagaimana mengasuh dan memenuhi kebutuhan tumbuh kembang anaknya.
Tokmányba fogott fúrószár szabad rezgéseinek mérése lézer Doppler módszerrel
Authors: Béres Miklós , Jenyó Tamás , Paripás Béla
Published: June 2021

Lézer Doppler interferométerrel (LDV) tokmányba fogott és megpendített fúrószárak keresztirányú rezgéseit tanulmányoztuk. Megállapítottuk, hogy a szabad rezgéseket általában két közeli (néhány %-on belüli) frekvenciájú komponens szuperpozíciójából származó lebegés dominálja, amelyek a fúrószárak horonyvég irányú és az arra merőleges keresztirányú rezgéséhez tartoznak. A hangvilla modell a 9mm átmérőjű fúrószár szabad rezgéseinek frekvenciáit pár százalékon belüli pontossággal megadja, a vastagabb (10 és 12mm-es) fúrószárak esetében viszont 15-20%-kal felülbecsli. Vizsgáltuk a fúróvég megtámasztásának, a fúrószár tokmányból kintebb húzásának és a koppintás típusának (tompa vagy éles) hatását is a rezgési spektrumra.
Inverse Nonlinear Eigenvalue Problem Framework for the Synthesis of Coupled-Resonator Filters With Non-Resonant Nodes and Arbitrary Frequency-Variant Couplings
Authors: Mrozowski Michal , Lamecki Adam , Mul Martyna , Gómez-García Roberto
Published: June 2021

A novel, general circuit-level description of coupled-resonator microwave filters is introduced in this paper. Unlike well-established coupling-matrix models based on frequency-invariant couplings or linear frequency-variant couplings (LFVCs), a model with arbitrary frequency-variant coupling (AFVC) coefficients is proposed. The engineered formulation is more general than prior-art ones and can be treated as an extension of previous synthesis models, since constant or linear couplings are special cases of arbitrary frequency dependence. The suggested model is fully general, allows for AFVCs with highly nonlinear (even singular) characteristics, loaded or unloaded non-resonating nodes (NRNs), frequency-dependent source-load coupling, multiple frequency-variant cross-couplings, and{/}or multiple dispersive couplings for connecting the source and load to the filter network. The model is accompanied by a powerful synthesis technique that is based on the zeros and poles of the admittance or scattering parameters and the eigenvalues of properly defined eigenproblems. In the most general case, the zeros and poles of the admittance or scattering parameters are related to solutions of nonlinear eigenvalue problems. The synthesis is defined as an inverse nonlinear eigenvalue problem (INEVP) where the matrix is constructed from three sets of eigenvalues. This is accomplished by optimization using an iterative nonlinear least-squares solver with excellent convergence property. Finally, third- and fifth-order examples of bandpass filter topologies involving AFVCs are shown, and the experimental validation of the proposed theory is presented through the manufacturing and characterization of a microstrip filter prototype with transmission zeros (TZs)
Contenidos infantiles convergentes, identidad latinoamericana y los desafíos de las televisiones públicas
Authors: Andrea Villarrubia-Martínez AVILLARRUBIA , Águeda Delgado-Ponce Águeda , Aguaded-Gómez Ignacio
Published: June 2021

Before the pandemic crisis, the irruption of the convergent scenario and the television digitalization forced the Latin American public television to develop strategies that consider new forms of audiovisual consumption and to make the resources profitable, such as the development of digital platforms and co-production with independent creators. Pakapaka, TVN and Señal Colombia coproduced children television programs with Chilean filmmakers that achieved a high audience and received acknowledgements at audiovisual festivals for their quality, their contribution to the local identity and Latin American own nature. Based on a content analysis carried out on tv shows aimed to children, present in both Chilean public digital platforms: CNTV Infantil (former Novasur) and TVN Kids, this study describes the collaborative model from the media literacy perspective, with emphasis on the diversity of children’s programs, considering their origins, acquisition, financing, and characteristics of the protagonist’s characters. The results indicate that the contents are varied and that the presence of female protagonists, native peoples and migrants, although incipient, constitutes a contribution to the identity of the continent’s childhoods. In conclusion, it is essential that public service television can count on permanent funding that promotes the realization of relevant content for children, in accordance with their public service mission, especially in today pandemic crisis and confinement.
A DÖNTÉS HÁTTERÉBEN ÁLLÓ KOGNITÍV KÉPESSÉGEK ÉS STRESSZ TOLERANCIA SZINTJÉNEK ÖSSZEHASONLÍTÓ ELEMZÉSE KEZDŐ ÉS TAPASZTALT SPORTOLÓKNÁL
Authors: Donka Dorottya Bianka , Balogh László
Published: June 2021

Bevezetés: Kiemelten fontos a csapatjátékokban, a kognitív képességek az érzékelés, észlelés, döntés (taktikai gondolkodás, tanulás, figyelem, gondolkodás, érzelmek) stressz tolerancia, sőt az ezek hátterében álló, a végrehajtás minőségét befolyásoló, motorikus képességek, technikai-taktikai képzettség szintje.

Célkitűzés: A játékintelligencia és stressz tűrőképesség vizsgálata során azt tapasztaltuk, hogy a kezdő/ fiatal és tapasztalt csapatsportolók stressz tűrőképességében van különbség (BALOGH, DONKA 2020). Az eredményeink azt mutatták, hogy a tapasztalt sportolóknak jobb a stressz tűrő képességük, azonban mivel ez egy leíró tanulmány volt, ezt az állításunkat szerettük volna nagyobb alanyszámmal is elvégezni, kognitív képességek vizsgálatának bevonásával is.Módszer: A kutatásunk módszere kísérlet. Keresztmetszeti vizsgálatot végeztünk 41 férfi és 13 nő csapatsportolón. Kognitív képességekre a VTS DT programcsomagját, stressz mérésre az MDE Heidelberg Stressz Holterét (gasztro, HR, TH, GSR) használtuk. A 35 perces mérés során az első szakaszban nyugalmi állapotot, a második szakaszban egy 10 perces stresszhelyzetre (kognitív tesztre VTS-DT) való reakciót, a harmadik szakaszban pedig egy megnyugvási állapotot, latenciát mértünk.Eredmények: Szignifikáns eredményeket kaptunk, miszerint valóban van kapcsolat a nők és férfiak stressz tűrő és kognitív képessége között. A sportágak összehasonlítása során is szignifikáns eredményeket kaptunk, hiszen a futballisták minden más csapathoz képest rosszabban tűrték a stresszt, és többet hibáztak a VTS-DT teszt során.Következtetések: A jövőben a kezdő és tapasztalt kategóriába való besorolást egységesebben szükséges végezni, valamint a sportágak szerinti egyenlőtlen alanyszámú részvétel sem kedvező. Azonban bíztató, hogy a szignifikáns eredményeknél egyértelmű kapcsolat mutatható ki a stressz tűrőképesség és a jó döntések száma között. Ezek az eredmények további kutatási területeket tárnak fel számunkra.
A TÁNC- ÉS MOZGÁSTERÁPIÁK SZEREPE A STRESSZKEZELÉSBEN
Authors: Barna Lilla , Balogh László
Published: June 2021

Napjainkban kedvelt kutatási téma az egészség és a fizikai aktivitás kapcsolata. Számtalan egészség megőrzési program segít elérni az egyén számára a fizikai aktivitás adta gyakorlási lehetőséget. Számos cikk írja le a fizikai aktivitás, ám valamivel kevesebb a tánc- és mozgásterápiák pozitív hatását a stressz kezeléssel kapcsolatban mind a gyermekek, fiatal felnőttek, középkorúak, illetve idősek, azon belül nők és férfiak számára egyaránt.

Az analízishez angol és magyar nyelvű vizsgálatok, szisztematikus tanulmányok áttekintését alkalmaztuk a stressz, a tánc- és mozgásterápiák kapcsolatának elemzésére a PubMed, a Google Scholar, a Cochrane Library, a ScienceDirect és a Reserch Gate adatbázisokból.

Napjaink egyik legnagyobb problémája a hétköznapokban megjelenő stressz annak kezeletlensége és egészségkárosító tulajdonságai. Így számos szakirodalomban számolnak be arról, hogy a tánc, mint fizikai aktivitás művelésével pozitív változás érhető el az egyensúlyi állapotból (homeosztázis) történő kibillenés és az arra történő reakció területén. Vizsgálatok bizonyítják, hogy a táncos mozgásprogramok (akár egyedül, párban, vagy csoportban) kisebb vagy nagyobb részt segítik a stressz kezelést és stresszre megjelenő reakciók feldolgozását.

Bizonyított, hogy a fizikai aktivitás hatására a stressz megjelenése és feldolgozása könnyebben kezelhető lesz. A tánc által az egyén kibillen a komfortzónájából számos koordinációs képességét és kognitív funkcióját aktivizálva, így kihasználva a mozgás és a zene adta pozitív következményeket, hatással lehet például a szorongás, a depresszió, az elszigetelődéssel járó megbetegedések kezelésében. Hiszen a tánc által rengeteg változás zajlik le mind a testben, mind az agyban, ezáltal boldogabbnak, kiegyensúlyozottabbnak érezheti magát az egyén, így életminősége, még ha csak a eleinte a mozgás időtartama alatt is, de pozitívan alakul.
Contrast Sensitivity Test After Phacoemulsification with Implantation of Hydrophobic Aspheric Monofocal Intraocular Lens (IOL) at Family Medical Center Hospital Sentul
Authors: Lesmana Michael Indra , Wastitiamurti Ritsia Anindita , Eusofe Nur Ezaithirah Nadihah binti Md
Published: June 2021

In Indonesia, the prevalence of cataract is 80 %. The main purpose of phacoemulsification with theimplantation of intraocular lens (IOL) is to improve visual acuity on cataract patient. The outcome ofcataract surgery should be evaluated based on visual acuity and quality of vision. Contrast sensitivityexamination can provide important information about the visual capabilities of individuals. The aim of thisresearch is to find out the contrast sensitivity value on cataract patients after phacoemulsification with theimplantation of hydrophobic aspheric monofocal IOL at FMC Hospital, Sentul on December 2018 untilJanuary 2019. This research used cross sectional descriptive design. The contrast sensitivity test isconducted on subject that fulfill the inclusive and exclusive criteria. This test is conducted using Vistech6500. The mean value of contrast sensitivity of 50 eyes at 1.5 cpd was 184.11, at 3 cpd was 235.5, at 6 cpdwas 207.360, at 12 cpd was 119.830, and at 18 cpd was 52.914. The result, the mean contrast sensitivity of50 eyes at the 1.5 and 3 cpd is higher compared to maximum value of Vistech 6500. However at 6, 12 and 18cpd the mean contras sensitivity depleted compared to maximum value of Vistech 6500. The result of meancontrast sensitivity based on age was the middle-aged (45-59 years) had a better contrast sensitivitycompare than young old (60-74 years) and very old category (75-90 years).
Perkembangan Terkini Terapi Sistemik Psoriasis
Authors: Sutanto Natalia Rania , Budianti Windy Keumala
Published: June 2021

Psoriasis merupakan penyakit inflamasi kulit akibat aktivasi terhadap sistem imun bawaan dan adaptif. Etiopatogenesis psoriasis merupakan proses kompleks dan multifaktorial, yang dipengaruhi oleh faktor genetik dan lingkungan seperti stres, trauma, dan infeksi. Pada pasien dengan psoriasis kategori sedang hingga berat dan lesi lokalisata di area skalp, wajah, kuku, telapak tangan dan kaki, serta genital merupakan indikasi untuk pemberian terapi dengan obat sistemik. Saat ini terdapat berbagai pilihan terapi sistemik yang tersedia yaitu obat sistemik konvensional, terapi small molecules, obat biologik, dan biosimilarnya yang terdiri atas inhibitor TNF-α, inhibitor IL-12/23, inhibitor IL-17, dan inhibitor IL-23. Selama dekade terakhir, tata laksana psoriasis telah mengalami pergeseran paradigma yaitu obat biologik dan biosimilarnya mulai menjadi pilihan utama karena telah terbukti memiliki efektivitas baik, dengan efek samping minimal. Tinjauan pustaka ini membahas perkembangan terapi sistemik psoriasis terkini sehingga diharapkan dapat memberikan acuan untuk memilih terapi yang tepat, efektif, dan aman untuk pasien psoriasis.
Traumatismo encefalocraneano moderado: un nuevo enfoque clínico para un término inadecuado
Authors: Aguilera Rodríguez Sergio , Iglesias Vargas Sebastián
Published: June 2021

El traumatismo encefalocraneano moderado es un grupo de pacientes muy heterogéneo y su mortalidad puede llegar hasta 15%, por lo que el término moderado debería ser reemplazado por traumatismo encefalocraneano potencialmente grave. Su evolución y pronóstico depende de una serie de factores que deben ser evaluados correctamente en la atención hospitalaria inicial del enfermo: edad, puntuación en la Escala de Glasgow, Escala tomográfica de Marshall y tipo de lesión intracraneana. Estos factores se relacionan fuertemente con la evolución del enfermo y las secuelas neurológicas posteriores. Lesiones como la hemorragia subaracnoidea traumática y especialmente la presencia de contusiones cerebrales están asociadas a secuelas neuropsicológicas que pueden ser muy invalidantes para los pacientes. Ahora bien, se deben distinguir al menos dos grupos de pacientes con TEC potencialmente grave: aquellos con Glasgow 11-13 y los pacientes con Glasgow 9-10 puntos. Este último grupo, de alto peligro de mala evolución clínica, si se asocia a una Tomografía Marshall III y IV inicial debieran ser considerados como traumatismo encefalocraneano grave desde la admisión. Un grupo de autores diseñó una categorización “tipo luces del semáforo” utilizando la Escala de Glasgow y la Clasificación de Marshall, lo que facilita reconocer al grupo de pacientes con más riesgo de mala evolución. Dentro del manejo neurointensivo, se debe recalcar la prevención de la hipotensión e hipoxia, la oportuna evacuación de lesiones ocupantes de espacio, el control intensivo de las variables fisiológicas y la neuromonitorización multimodal en el grupo de mayor riesgo. Todas estas medidas lograrán disminuir la mortalidad y mejorar el pronóstico de un grupo de pacientes cuya injuria cerebral primaria no determinó un daño cerebral inicial devastador.
Domestic experience in development of die step rolling mills
Authors: Aryulin S.B.
Published: June 2021

The domestic experience in designing of die step rolling mills is presented. Structures and principles of rolling mills operation are analyzed, their advantages, which determine the field of application, are indicated. Information on the pilot and industrial operation of step rolling mills is given.
Enfoque social de las construcciones de viviendas con paredes de ferro-cemento en la ciudad de Portoviejo, Manabí
Authors: Zambrano De La Torre Roberth , Mauricio Jarre César
Published: June 2021

En el Ecuador existe una alta demanda de viviendas de interés social, país donde se desarrolló la investigación. El objetivo de estudio fue analizar la alternativa del uso del ferro-cemento en la construcción de vivienda social en el cantón Portoviejo, provincia de Manabí, Ecuador. La investigación fue descriptiva, se fundamentó en la búsqueda de información de fuentes bibliográficas, además, se recopiló información empírica mediante una encuesta validada por expertos en la construcción, la misma que buscó obtener información real acerca del uso y conocimiento del material por parte de los profesionales para el análisis de viabilidad. El procesamiento y análisis de los datos se lo realizó en el software SPSS versión 25. La medición y cálculo del presupuesto de una vivienda de interés social permitió determinar el costo final de una vivienda T8. La población de 3121 ingenieros civiles registrados en el respectivo colegio profesional provincial, de la cual se investigó una muestra de 115 profesionales, el nivel de significancia fue de ± 8%. Como resultado de mayor relevancia de la investigación se obtuvo que una vivienda de interés social construida con paredes de Ferro-Cemento es más económica que una construida con materiales tradicionales (bloques o ladrillos), como también aportando igual o mejor resistencia y seguridad ante las exigencias normativas sismo resistentes.
Conduct Unbecoming? Teacher Professionalism, Ethical Codes, and Shifting Social Expectations
Authors: Cochran Natasha , Lemisko Lynn
Published: June 2021

In this paper, we share findings from a historical investigation into changing expectations regarding teacher conduct as connected to the evolving Saskatchewan Teachers’ Federation Code of Ethics and the eventual proclamation of a Government-mandated teacher regulatory board. This study was based on the idea that views of appropriate conduct embedded in ethical codes evolve in relation to shifting societal norms and values. We demonstrate that the tone and content of ethical codes of conduct for Saskatchewan teachers transformed from explicit and concrete to abstract and ambiguous.

            Keywords: conduct unbecoming; code of ethics; teacher regulation; teaching profession
Curriculum Integration and the Forgotten Indigenous Students: Reflecting on Métis Teachers’ Experience
Authors: Gillies Carmen Leigh
Published: June 2021

Curriculum integration, or in other words, changing what students are taught within racially desegregated Canadian schools, has served as a primary but incomplete pathway to racial justice. In this paper, I present evidence from a qualitative critical race theory (CRT) methodological study with 13 Métis teachers to demonstrate how curricular integration has been framed as a key solution to inequitable outcomes concerning Indigenous students. This strategy has been instilled within the Saskatchewan K–12 education system by a wide spectrum of authorities over several decades. Although absolutely essential for multiple reasons, I argue that teaching students about Indigenous knowledge systems and experiences, as well as anti-racist content, cannot resolve the systemic racial injustices encountered by Indigenous students who attend provincial schools. In particular, three CRT analytical tools—structural determinism, anti-essentialism, and interest convergence—are utilized to examine the limitations of curricular integration as a strategy of racial justice.

Keywords: Métis teachers; Indigenous education; critical race theory; integrated schools
A Review of Silencing Ivan Illich: A Foucauldian Analysis of Educational Exclusion by David Gabbard
Authors: Cappello Michael
Published: June 2021

A Review of Silencing Ivan Illich: A Foucauldian Analysis of Educational Exclusion by David Gabbard
Topical Wound Healing, Antimicrobial and Antioxidant Potential of Mimosa pudica Linn root Extracted using n-Hexane Followed by Methanol, Fortified in Ointment Base
Authors: Singh Sangeeta , Dodiya Tanvi R , Singh Sudarshan , Dodiya Rajesh
Published: June 2021

Mimosa pudica Linn is an ornamental perennial herb belonging to the taxonomic group of Magnoliopsida and family Leguminaceae. Besides its ornamental use, Mimosa pudica is also a popular plant among folk healers to treat several diseases including bleeding disorders such as menorrhagia, dysentry with blood, mucus and piles, and wound healing. In this study, roots of Mimosa pudica was successively extracted with hexane, ethyl acetate, and methanol to evaluate the folkloric assert of plant in view of antioxidant, antibacterial, and wound healing potential. Methanolic extract showed concentration dependent elevation in inhibition for radical scavenging assay following dpph with maximum effect of 73.43% against standard ascorbic acid equivalent to 250 µg/ml, however IC50 of extract with n-hexane and ethyl acetate exhibited relatively poor antioxidant efficacy. Minimum inhibitory concentration demonstrated higher inhibitory action in range of 1.25-0.625 mg/ml against tested gram positive Staphylococcus aureus -MTCC737, and Bacillus subtilis-MTCC110 and 2.5 mg/ml for gram negative Salmonella typhi-MTCC15442, Escherichia coli-MTCC118 micro-organism for methanolic extract compared to ethyl acetate extract, however hexane extract showed MIC > 2.5 mg/ml. Among the tested solvent system for column chromatography, fractionation with diethyl ether: methanol (1:4) demonstrated single clear spot with Rf value 0.72 for methanolic extract indicated presence of flavonoid as major phytoconstituents. The results of spectral analysis following fourier transform spectroscopy, nuclear magnetic resonance, and mass spectroscopy for purified isolated compound confirmed identity of isolated flavonoid from methanolic fraction with chemical name 7,8,3’,4’-tetrahydroxy-6-methoxy-flavone. Thus, overall results demonstrated that Mimosa pudica root extract have potential antioxidant and antimicrobial efficacy. Furthermore, the Mimosa pudica root extracted with n-hexane followed by methanol fortified in a pharmaceutical formulation ointment base demonstrated excellent wound healing efficacy compared to marketed povidone-iodine ointment. Therefore, traditional claim for the use of Mimosa pudica root as potential antioxidant, antimicrobial, and wound healer in topical drug delivery have been proven by the present study.