bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of pre-transplant dialysis modality on the outcome and health-related quality of life of patients after simultaneous pancreas-kidney transplantation
Authors: Scheuermann Uwe , Rademacher Sebastian , Jahn Nora , Sucher Elisabeth , Seehofer Daniel , Sucher Robert , Hau Hans-Michael
Published: January 2020

Background Simultaneous pancreas-kidney transplantation (SPKT) profoundly improves the Health-related quality of life (HRQoL) of the recipients. However, the influence of the pre-transplant dialysis modality on the success of the SPKT and post-transplant HRQoL is still unknown. Methods We analyzed the surgical outcome, long-term survival, as well as HRQoL of 83 SPKTs that were performed between 2000 and 2016 in our Hospital. Prior to transplant, 63 patients received hemodialysis (HD) and 19 patients received peritoneal dialysis (PD). Physical and mental quality of life results from eight basic scales and the physical and mental component summaries (PCS and MCS) were measured using the Short Form 36 (SF-36) survey. Results Peri- and postoperative complications, as well as patient and graft survival were similar in both groups. Both groups showed improvement of HRQoL in all SF-36 domains after transplantation. Compared to patients who received HD before transplantation, PD-patients showed significantly better results in five of the eight SF-36 domains: physical functioning (P = 0.02), bodily pain (P = 0.001), general health (P = 0.038), vitality (P = 0.014), role limitations emotional (P = 0.048) and PCS (P = 0.002) after SPKT. In the overall study population, graft loss was associated with significant worsening of the HRQoL in all physical components (each P < 0.01). Conclusions The results of this analysis show that pre-transplant dialysis modality has no influence on outcome and survival rate after SPKT. Regarding HRQoL, patients receiving PD prior to SPKT seems to entail a slight advantage compared to patients with HD before transplantation.
Evaluation of a homemade saliva kit for the stabilization of plasmodium dna at room temperature
Authors: Netongo Palmer Masumbe , Tchoupe Eric Berenger , Kamdem Severin Donald , Chedjou Jean-Paul , Mbacham Wilfred Fon
Published: January 2020

Objectives : Most malaria diagnostic methods are invasive whereas non-invasive alternatives like saliva could be used for molecular diagnosis. However, long-term storage of saliva also requires a cold chain, which is challenging in poor countries. Current tools to conserve saliva at room temperature are not affordable (~$16/kit) for malaria endemic countries. In this cross-sectional study including 83 febrile participants, we evaluated the effectiveness of a cheaper (~$2/kit) homemade kit (Formulation f1 ) to stabilize Plasmodium DNA in saliva stored at room temperature for 12 months. The OMNIgene ® ORAL (OM-501) kit served as standard (S0 ). Results : The frequency of malaria in this study was 78.31% (65/83) using microscopy. Saliva PCR-f1 and PCR-S0 detected 59 (71.08%) and 56 (67.47%) positive malaria samples respectively. Using microscopy as gold standard, the sensitivities of PCR-S0 and PCR-f1 were 100% while the specificities were 80%, and 85%, respectively. PCR-f1 had a “very good” agreement (kappa 0.81) with microscopy compared to PCR-S0 (kappa 0.64). We obtained similar results after 12 months storage of saliva samples at room temperature (RT). Homemade kit could be effective in transportation, preservation and diagnosis of malaria parasite in saliva. Key words: Non-invasive, Saliva, DNA, Plasmodium , Malaria, Homemade kit.
Study on the influencing factors and prediction of the medical cost of chronic renal failure in China based on a decision tree algorithm
Authors: dai pingping , Luo Aijing , Chang Weifu , Xin Zirui , Cheng Haiwei , Ouyang Wei
Published: January 2020

Purpose: The objective of this study is to explore the factors that affect the hospitalization costs for patients with chronic renal failure (CRF) and to extract relevant characteristics for modeling, so as to make predictions about hospitalization costs for CRF patients. Methods: This study collected the data on the first page of the 2014 medical records of three first-class tertiary hospitals in Beijing. Using IBM SPSS Modeler software, we used the chi-squared automatic interaction detector (CHAID) and classification and regression tree (CART) algorithms to construct a prediction model of the hospitalization costs for CRF patients and conducted a comparative analysis. The data of the 1819 cases in this study included the index variables on the first page of the medical records, which covered social economics, clinical characteristics, and medical consumption. The input variables included medical payment method, sex, age, marital status, length of hospital stay, main diagnosis, number of other diagnoses, major surgery, and number of surgeries. The target variable was the total medical expense. Results: Our results showed that medical payment method, sex, age, marital status, length of hospital stay, main diagnosis, number of other diagnoses, major surgery, and number of surgeries all had an effect on hospitalization cost. There was no significant difference in the prediction models of the total hospitalization cost constructed using the CHAID and CART algorithms. Conclusions: Major surgery and length of hospital stay were important predictor variables for modeling with both CHAID and CART algorithms. The length of hospital stay should be included in the grouping variables when disease-related grouping and prediction of medical costs are done for CRF patients.
Occurrence, risk factors and genotypes of Enterocytozoon bieneusi in dogs and cats in Guangzhou, southern China: high genotype diversity and zoonotic concern
Authors: Wang Haiyan , Lin Xuhui , Sun Yongxiang , Qi Nanshan , Lv Minna , Xiao Wenwan , Chen Yuan-Cai , Xiang Ruiping , Sun mingfei , Zhang Longxian
Published: January 2020

Background: Enterocytozoon bieneusi, an obligate protist pathogen, has a wide range of hosts. Limited epidemiological data on E. bieneusi intestinal infections in companion animals (dogs and cats) in China exists. In this study, fecal samples (651 from dogs and 389from cats) in Guangzhou city, Guangdong Province, China, were collected, and the ribosomal internal transcribed spacer region from the DNA extracted from them was PCR-amplified and sequenced.Results: Based on the sequencing data, E. bieneusiwas identified in the fecal samples collected from 149 (22.9%) and 79 (20.3%) dogs and cats. Of the factors investigated, poor living conditions appeared be the major risk factor for contracting the pathogen. Eleven E. bieneusi genotypes, six known (PtEb IX,GD1, D,CD9, EbpC, I) and five novel (designated here as GD2–GD6), were found in dogs. Eight genotypes, six known (PtEbIX, GD1, D, CD9, EbpC, Type IV) and two novel (GD2 and GC1), were identified in cats. Genotype PtEb IX was most common in both dogs and cats.Conclusions: Although PtEb IX was the most common E. bieneusi genotype in dogs, this is the first report of this genotype dominating in cats. The same genotype distribution of the pathogen between the two different companion animal species in the same geographic area indicates that inter-species transmission is probable. The widespread existence of zoonotic E. bieneusig enotypes in companion animals indicates that they are potential sources of environmental contamination and infections in humans.
The adjuvant chemotherapy can be omitted for lepidic predominant lung adenocarcinoma in stage IB of the 8th TNM staging system.
Authors: Ito Hiroyuki , Nakayama Haruhiko , Nagashima Takuya , Samejima Joji , Inafuku Kenji , Eriguchi Daisuke , Yamada Kouzo , Suzuki Masaki , Yokose Tomoyuki
Published: January 2020

ObjectivesThis study was designed to investigate whether the outcomes of adjuvant chemotherapy are affected by the lung adenocarcinoma predominant (AP) in stage IB according to the 8th UICC staging system. Methods From 2008 through 2015, 293 patients with pathological stage IB who were ≤ 75-year-old and underwent lobectomy were studied. The relations of clinicopathological factors were investigated by propensity score matching.ResultsThe median follow-up period was 66.0 months. The cases of AP were followed: lepidic 96, acinar 71, papillary 54, solid 45, micropapillary 3 and others 17. Adjuvant chemotherapy with UFT was performed in 70 cases (23.9%). Recurrence-free survival at 5 years (RFS) was 72.2%. Lymph vessel invasion (ly+), vascular vessel invasion (v+), pleural invasion (pl+) and non-lepidic statistically affected RFS. Multivariate analysis showed that only AP (non-lepidic) was significant (hazard ratio; HR=2.006 (1.104-3.644)). Overall survival (OS) rate at 5 years was 83.5%. ly+, v+, pl+, EGFR mutation status and AP affected OS. In multivariate analysis, only non-lepidic was left (HR=2.888 (1.231 - 6.774)). After matching AP, adjuvant chemotherapy did not have an impact on RFS or OS (p=0.992, 0.616). In lepidic, both adjuvant and non-adjuvant had excellent outcomes in RFS (84.8% and 92.9%, p=0.574) and OS (100% vs 100%, p=0.361). In non-lepidic group, adjuvant therapy tended to show slightly, but not significantly better RFS (71.5% vs, 60.6%, p=0.177). ConclusionLepidic predominant showed excellent outcomes, adjuvant chemotherapy is not necessary. For non-lepidic predominant, UFT remains standard adjuvant chemotherapy in Japan.
Trust is the engine of change: A conceptual model for trust building in health systems
Authors: Adam Mary B. , Donelson Angela Joy
Published: January 2020

Background: Physicians, health care organizations, governments and communities are increasingly interested in how trust is built throughout the health system. Current science on building trust draws on diverse literature from business and consumer science to healthcare, and theory development has predominately focused on factor based models. We propose a process based theoretical model for trust building which may better reflect the complex and dynamic nature of trust itself. In doing so, we propose a new measurable dimension of the trust building process: reciprocity cycles. Cooperative reciprocal relationships are its building blocks, enabling stakeholders to “try out” their interactions with less risk, and to calibrate their level of effort, time and emotional investment. Reciprocity cycles includes three measurable elements: common goals, self-interests and gratitude/indebtedness.Methods: We applied the model, developing outcomes and measures in close-to-community health partnerships in Kenya. A 3-day workshop designed to stimulate problem solving and collaborative teamwork using human centered design principles was offered in 2 community health units in diverse contexts (rural agrarian and peri-urban flower farm slum), each with about 30 community health volunteers (CHVs) serving a population of approximately 5,000. Each unit formed separate teams representing specific villages; we followed these 9 teams between 18 to 24 months.Results: All 9 volunteer CHV teams delivered on self-directed public health outcomes across the spectrum of social determinants of health over the follow up period, with no funding, only using their own locally available resources. Projects were diverse, including immunization, composting toilets, hygiene, neonatal and reproductive health and public gardening. All 9 teams demonstrated trust building reciprocity cycles with articulation of common goal, self-interest, and gratitude/indebtedness. Conclusion: A process model of trust building, defined by reciprocity cycles, can be stimulated with a short intervention (illustrated here in close-to-community health systems) resulting in trusting relationships that drive agency and co-production of positive outcomes for health systems. In addition, it offers a simpler, more useful framework for trust building and measurement than traditional models of trust in health systems research. Early findings illustrate reciprocity cycles are scalable and adaptable, with potential utility at multiple levels of health systems.
A Missed Opportunity to Prevent Subsequent Fractures Confirmed through Trends in the Treatment of Osteoporosis in Patients with Distal Radius and Hip Fractures
Authors: Kim Dae-Geun , Jang Hae-Dong , Seo Gi-Won , Lee Hyun-Uk , Nam Hye-Won
Published: January 2020

Background A history of osteoporotic fracture (OF) is strongly associated with subsequent OFs. It is important to treat osteoporosis following OFs to prevent subsequent fractures. A distal radius fracture (DRF) is the most common type of OF in people in their 50s and could be a hallmark of future OFs. We compared the rate of osteoporosis treatment within 6 months post-DRF with hip fracture (HF). Methods We used data from the Korean Health Insurance Review and Assessment Service nationwide claims database from 2010 to 2016. International Classification of Diseases 10th revision (ICD-10) codes and procedures codes were used to identify patients older than 50 years with newly diagnosed DRFs and HFs. Then the rate of prescription and kinds of osteoporosis medications in these patients were analysed. We also compared the trends in both groups using the Cochran–Armitage trend test. Results A database search identified 77,209 DRFs and 72,044 HFs in patient aged 50 years or older from 2011 to 2016. Insufficient DRF and HF patients had osteoporosis medications (17.2% and 34.5%) and the numbers of osteoporosis medication for both DRFs and HFs decreased significantly annually ( P <0.0001). Bisphosphonates were used most often, although the use of selective oestrogen receptor modifiers (SERMs) increased gradually in both groups.Conclusions Clinicians who treat OFs should treat osteoporosis to prevent subsequent fractures and pay more attention to DRF patients who fail to get proper osteoporosis treatment.
Existence of multilineage mesenchymal progenitor cells in human atrophic nonunion tissue
Authors: Zhang Xianghong , Tang Zhongwen , Wan Jia , Jiang Guangyao , Yang Daishui , Zhang Xiangsheng , Liu Tang
Published: January 2020

Background : Though the treatment of atrophic nonunion is often challenging, bone union may occurs in some patients with atrophic nonunion who underwent indirect treatment at the docking site. We aimed at explaining the reasons why does this phenomenon appear? Methods : Five patients diagnosed with atrophic nonunion were enrolled in our study. Nonunion tissues were cut into strips and cultured immediately after being obtained. We got the adherent cells from atrophic nonunion tissues, and applied the flow cytometry to assess the expression of different cell-surface protein. The research in differentiation of the adherent cells was carried out under the induction of various lineage-specific factors, and Western-blot analysis was used to measure the differentiation-related protein expression. Results : We found that the adherent cells from atrophic nonunion tissues have the characteristics similar to bone marrow stromal cells. These traits demonstrated by the flow cytometry consist of positive expression of markers CD29 and CD44, but negative expression of CD34 and CD45. The adherent cells could differentiate into osteogenic, chondrogenic, and adipogenic cells under the different lineage-specific induction factors in vitro. Alkaline Phosphatase (ALP), Col Ⅱ, osteocalcin (OC), SOX9, lipoprotein lipase (LPL) and PPAR-γ2 were high expressed, as measured by Western-blotting. Conclusions : Mesenchymal stem cells obtaining from atrophic nonunion tissues have the potential of transforming into cartilage and bone-forming cells. Furthermore, we get conclusion that the atrophic nonunion tissues play an important role in the healing process.
MicroRNAs in small extracellular vesicles indicate successful embryo implantation during early pregnancy
Authors: Tan Qiang , Shi Shuang , Liang Jingjie , Zhang Xiaowei , Cao Dingren , Wang Zhengguang
Published: January 2020

Background : Synchronous communication between the developing embryo and the receptive endometrium is required for successful embryo implantation. Assessing of uterine receptivity is important for overcoming the recurrent implantation failure (RIF). Although the potential roles of small extracellular vesicles (sEVs) miRNAs in pregnancy have repeatedly mentioned, the systematic study of sEVs derived from endometrium and its cargoes during the implantation have not yet been reported. Methods : In this study, sEVs were isolated from mouse uterine cavity on D2 (pre-receptive phase), D4 (receptive phase) and D5 (implantation) of pregnancy using ultracentrifugation and analyzed by transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). The miRNAs expression profiles of sEVs were identified by RT-qPCR. The datasets analysis of RIF were employed by an integrative bioinformatics analysis. The protein markers of sEVs were examined by western blotting. The effects of miRNAs in embryo implantation were determined by an agomir injection test. Results : Here we show that the number of multivesicular bodies (MVBs) in the endometrium is increased during the window of implantation (WOI). Meanwhile, the expression of CD63 is mainly located in the luminal and glandular epithelium. sEVs miRNAs profile reveal that miR-34c-5p, miR-210, miR-369-5p, miR-30b and miR-582-5p are enriched during WOI. By further integrating the database analysis results of RIF, we found that miR-34c-5p regulates GAS1 to involve normal process of embryo implantation. It is interesting that miR-34c-5p is down-regulated during implantation but enriched in sEVs. An implication of this is the possibility that sEVs miR-34c-5p could be used to evaluate uterine states. Conclusion : Our study identified that mouse endometrium release sEVs during the early stage of pregnancy, especially during WOI. We found that miR-34c-5p in sEVs affects embryo implantation by targeting to GAS1. Furthermore, the sEVs miRNAs suggest potential biomarkers for the choose of suitable period for embryo implantation. This study also has a number of important implications for future practice.
ADAR expression and copy number variation in patients with advanced gastric cancer
Authors: Behroozi Javad , Shahbazi Shirin , Bakhtiarizadeh Mohammad Reza , Mahmoodzadeh Habibollah
Published: January 2020

Background Gastric cancer (GC) is a world health problem and it is the third leading cause of cancer deaths worldwide. The current practice for prognosis assessment in GC is based on radiological and pathological criteria and they may not result in an accurate prognosis. The aim of this study is to evaluate expression and copy number variation of the ADAR gene in advanced GC and clarify its correlation with survival and histopathological characteristics. Methods Forty two patients with stage III and IV GC were included in this study. ADAR gene expression and copy number variation were measured by real-time PCR and Quantitative multiplex ﬂuorescent-PCR, respectively. Survival analysis performed based on the Kaplan–Meier method and Mantel–Cox test. Results ADAR mRNA was significantly overexpressed in the tumor tissues when compared to the adjacent normal tissues (p <0.01). Also, ADAR expression level in stage IV was higher than stage III. 40% of patients showed amplification in ADAR gene and there was a positive correlation between ADAR copy number and expression. Increased ADAR expression was clearly correlated with poorer survival outcomes and Mantel–Cox test showed statistically significant differences between low and high expression groups (p <0.0001). ADAR overexpression and amplification were significantly associated with metastasis, size and stage of tumor. Conclusions Together, our data indicate that amplification leads to over expression of ADAR and it could be used as a prognostic biomarker for disease progression, especially for the metastatic process in GC. Keywords Gastric cancer, ADAR gene, Overexpression, Amplification, Prognosis
”I Am Satisfied with My Marriage”: An Experience from Madurese Women who Married Early
Authors: Bawono Yudho , Suminar Dewi Retno , Hendriani Wiwin
Published: January 2020

The research aimed at examining ways by which Madurese women could achieve satisfaction in early marriage. Its used a qualitative research method with an interpretative phenomenological analysis (IPA). To understand the meaning of one’s experience by looking for themes from available data, IPA rested on three pillars, namely phenomenology, hermeneutics, and idiography. The researchers used semi-structured interviews to collect data and purposive homogeneous sampling. The participants involved were three married women under 18 years old who were living in Madura. The results of the research show that the three women are satisfied with their marriage. The satisfaction of their marriage can be seen from taking care of each other when sick, giving her enough money, and always happy with her husband, not far apart. Furthermore, Madurese women dissatisfaction in her marriage can be seen from anger if she is not given money and is not helped in doing household.
The Cultural Meaning in Verbal and Non Verbal Expression Represented in Nyaébuh Tradition of People in Aeng Tong-tong, Saronggi, Sumenep
Authors: Hodairiyah Hodairiyah , Rais Wakit Abdullah , Purnanto Dwi
Published: January 2020

This research aimed to find out the cultural meaning of verbal and non-verbal expression represented in the nyaébuh tradition of people in Aeng tong-tong, Saronggi, Sumenep. This research was a qualitative descriptive using an ethnographic method with ethnoscience analysis. Data were obtained from the interview result with two informants of verbal and non-verbal expression. It finds that this tradition in the form of almsgiving whereby the charity is devoted to the deceased in the hope that it can alleviate and erase the sins of the deceased, in addition to which it can increase unity, harmony, family, harmony between people and others. This research can provide the benefits of knowledge about the meaning contained in the tradition of nyaébuh, and it can give the Sumenep community’s insights about the meaning of tradition through verbal and non-verbal language expressions. Besides that, it can share knowledge about the culture and traditions of Madura for each different region.
The Translation of Lexical Collocations in Undergraduate Students’ Theses’ Abstract: Students Versus Google Translate
Authors: Karjo Clara Herlina , Metta Ecclesia
Published: January 2020

This research intended to compare the translations of lexical collocations found in the abstract section of students’ theses. The purposes were to find out the errors in translating lexical collocation either by Google Translate or student translator. The data were taken from twenty working papers of English Literature students at Binus University. The abstracts of these theses (in English and Indonesian) were then processed with Google Translate. Thus, there were four sets of data to analyze: (1) Students’ Text in Indonesian (STI), (2) Google Translate of STI in English (GTE), (3) Students’ Text in English (STE), and (4) Google Translate of STE in Indonesian (GTI). From the data, samples of collocations were taken and categorized based on Hill’s classification of lexical collocations. The lexical collocations found in the four sets of data were scrutinized, compared, and analyzed to find the errors in forms and meaning as well as in the translation. The results reveal that errors in translating collocations are mostly made by Google Translate rather than the students. This research implies that Google Translate still needs improvement in translating collocations, but it is also possible that translation errors occur because of students’ misuse of collocation.
The Impact of Higher Order Thinking Skills (HOTS) Instructions in Teaching EFL Speaking Skill from the Perspective of Students’ Motivation
Authors: Purnama Yuniarta Ita , Nurdianingsih Fitri
Published: January 2020

The purpose of the research was to examine (1) whether or not the HOTS instruction was more effective than the LOTS (Lower Order Thinking Skills) instruction in teaching speaking for daily context to the first semester students at English Education department; (2) whether the students who had high self-motivation had better speaking ability than those who had low self-motivation; and (3) whether there was an interaction between teaching strategies and students’ self-motivation. By using a quantitative research with the quasi-experimental type, the data were derived from tests and questionnaires. The results show that (1) HOTS instruction is more effective than the LOTS instruction in teaching speaking for daily context to the first semester students at the English Education Department; (2) the students who have high motivation have better speaking skills than the students who have low motivation; (3) there is an interaction between teaching strategies and motivation in teaching speaking for daily context. It can be concluded that HOTS instruction is an effective strategy in teaching speaking viewed from students’ motivation. The effectiveness of the strategy is affected by students’ motivation.
PREMENSTRUAL SYNDROME: CLINICAL PATTERN, DIAGNOSTICS AND THERAPEUTIC APPROACHES
Authors: Guliyeva L. P. , Yureneva S. V.
Published: January 2020

Premenstrual syndrome (PMS) is a complex, cyclical, polyethiological, multifactorial combination of physical and mental disorders that occur in some women of reproductive age in the second - luteal - phase of the menstrual cycle and negatively affect the woman’s usual lifestyle.

Premenstrual dysphoric disorder (PMDD) is a severe form of PMS in which psychoneurological symptoms prevail. For the diagnosis of PMDD, the specific DSM-5 criteria were developed by the American Psychiatric Association according to which the the diagnosis is confirmed by the presence of five or more symptoms in women during the week prior to menstruation and their disappearance a few days after the onset of menstruation. These symptoms are observed for at least two cycles.

Treatment of women with PMS/PMDD, first of all, should start with the lifestyle adjustment, inclusion of regular mode rate physical activity into daily activities. The effectiveness of vitamins B6, E and calcium has not been confirmed in studies. First-line drug therapy includes SSRIs or combined oral contraceptives containing drospirenone are prescribed first, then agonists of gonadotropin-releasing hormone.
THE PLACE OF «EPIGEN SPRAY» IN THE TREATMENT AND PREVENTION HPV-ASSOCIATED LESIONS OF THE CERVIX
Authors: Borovikov I. O. , Kucenko I. I. , Kravcova E. I. , Bulgakova V. P.
Published: January 2020

Because of the conducted microbiological research cervic-vaginal zone with carriers of human papilloma virus identified local factors homeostasis that contribute to the progression of the process with a cervical lesion as cervical intraepithelial neoplasia. The comparative analysis of prophylactic use of eubiotiks and acid glycyrrhizinic drug for the prevention of HPV-associated lesions of the cervix.
SECOND TRIMESTER MEDICAL TERMINATION OF PREGNANCY. CHALLENGES OF IMPLEMENTATION
Authors: Apresyan S. V. , Dimitrova V. I. , Slyusareva O. A.
Published: January 2020

The article describes the specific features of termination of progressive uterine pregnancy in the II trimester. It was found that the efficacy of medical abortion in the II trimester of pregnancy is 94–98%. High efficacy, low incidence of side effects or early and late complications and economic feasibility demonstrate that the method is promising and safe; therefore, it can be recommended as a priority when choosing a method for medical termination of pregnancy in the II trimester.
USING RESULTS OF FIRST-TRIMESTER BIOCHEMICAL SCREENING AND UTERINE ARTERY PULSATILITY INDEX FOR INCLUSION IN RISK GROUPS FOR FETAL GROWTH RESTRICTION
Authors: Zamaleeva R. S. , Cherepanova N. A. , Frizin D. V. , Frizina A. V.
Published: January 2020

Objective: to study the combined use of first-trimester biochemical screening results and uterine artery pulsality index (PI) for inclusion in risk group for fetal growth restriction (FGR), improvement of pregnancy outcomes in women from the risk group for the development of FGR.

Material and methods. The work is based on the results of studies conducted from 2009 to 2014 in the maternity unit of Republican Clinical Hospital № 2 MoH in the Republic of Tatarstan which is the clinical facility for the Department of Obstetrics and Gynecology № 1 of the Continuing Medical Education Institution “Kazan State Medical University” MoH RF, and maternity unit and prenatal clinic of the Volzhskaya Central City Hospital in the Mari El Republic. First-trimester biochemical screening results and uterine artery PI were the basis for the formation of FGR risk groups. Pregnancy and delivery outcomes in 156 pregnant women with a risk for the development of FGR and in 25 healthy controls were evaluated. In order to improve the placental blood flow based on the proven safety profile, all women with FGR received dipyridamole in the II trimester of pregnancy for at least 3 weeks.

Conclusion: concomitant decrease in PAPP-A MoM and increase in uterine artery PI provide the most valuable information for forecasting FGR. Administration of dipyridamole by women with FGR helps to improve placental blood flow, prevents degenerative changes in the placenta, and promotes live births even in III degree FGR.
PREBIOTIC CORRECTION IN BACTERIAL VAGINOSIS
Authors: Tikhomirov A. L. , Kazenashev V. V. , Sarsaniya S. I. , Tuskaev K. S.
Published: January 2020

Increased interest to the vaginal microecosystems is largely due to the fact that the role of evolutionary formed microbial populations in this habitat lies not only in the maintenance of vaginal colonization resistance, but also in formation of microecological health of newborns, and consequently, the human population in general.

The formation of the qualitative and quantitative composition of microflora is regulated by a complex mechanism of microbial interactions inside each of microecosystems and is controlled by physiological factors of the host organism in the dynamics of his life.
CHANGES OF SKIN AND ORAL MUCOSA IN DIABETES MELLITUS AND THEIR PREVENTION
Authors: Verebovoy A. F. , Sharonova L. A. , Burakshaev S. A. , Kotelnikova E. V.
Published: January 2020

In article the most often arising diseases from skin are described and a mucosa of an oral cavity at patients with a diabetes mellitus: mechanisms of their emergence, prophylaxis methods.
SECONDARY HYPOTHYROIDISM: CURRENT APPROACHES TO DIAGNOSIS AND TREATMENT
Authors: Gavrilova T. A. , Morgunova T. B. , Fadeev V. V.
Published: January 2020

Secondary hypothyroidism is a very rare cause of hypothyroidism in adults. Clinical manifestations of secondary as well as primary hypothyroidism are nonspecific; in addition, thyroid hormone deficiency often clinically simulates other tropic hormone deficiencies, thus complicating timely diagnosis of the disease. Certain difficulties are also caused by replacement therapy in secondary hypothyroidism, since the level of free thyroxine in the blood is used as the criterion for evaluating levothyroxine dosage, and questions about the use of peripheral markers of thyroid function to assess the adequacy of therapy remain understudied.
ORLISTAT IN COMBINATION THERAPY OF OBESITY AND TYPE 2 DIABETES
Authors: Mkrtumyan A. M. , Biryukova E. V.
Published: January 2020

Over the past years, the focus has been growing on the prevention and treatment of obesity. Obesity has long been considered not just as excess body fat but as a chronic relapsing disease, the result of energy disbalance, which develops with an increase in food intake and reduced energy expenditure and is closely associated with a number of serious complications. Orlistat (Xenical), a peripherally acting drug without systemic effects [11, 24, 27], has been widely used in pharmacological treatment of obesity. Xenical is the most well-studied medication for weight loss. More than 30,000 patients with obesity were involved in clinical trials, of which over 2,500 patients had type 2 diabetes. Till today, the drug remains a breakthrough in the treatment of overweight/obesity.
RESULTS OF A 20-YEAR FOLLOW-UP OF CHILDREN WITH GROWTH HORMONE DEFICIENCY IN THE REPUBLIC OF TATARSTAN
Authors: Sultanova L. M. , Pecheritsa O. G. , Krinitskaya N. V.
Published: January 2020

One of the most important parameters of health in children is growth. Stunted growth leads to the development of inferiority complex in patients and often hampers social self-realization. Over the past two decades, the Republic of Tatarstan has been actively diagnosing and treating growth hormone deficiency in children with short stature. Children with isolated growth hormone deficiency receive monotherapy with recombinant growth hormone. Early treatment of children with growth hormone deficiency led to an improvement in anthropometric parameters and, consequently, psychological and social adaptation of this group of patients.
VITAMINS. PREVENTION AND TREATMENT OF COMPLICATIONS IN PATIENTS WITH DIABETES MELLITUS
Authors: Podachina S. V.
Published: January 2020

Hyperglycemia is a major cause of complications in patients with diabetes mellitus (DM). Since the optimal level of glycemic control is achieved only in a small number of patients with diabetes mellitus, additional methods of prevention and treatment of complications are strongly recommended. The focus of healthcare specialists is increasing on substances that can affect intracellular pathological processes associated with hyperglycemia. Such drugs or agents include certain vitamins and minerals.
ROLE OF MINERAL WATER «DONAT MG» IN THERAPEUTIC PRACTICE
Authors: Pogorelova A. S.
Published: January 2020

«Donat Mg» is highly mineralized sulphate-hydrocarbonate sodium-magnesium water with unique healing properties. It course intake not only promotes normalization of the gastrointestinal tract, but also prevents cardiovascular disease, having a positive effect on the status of carbohydrate, protein and fat metabolism.
Cost-benefit of promising adaptations for resilient development in climate hotspots: evidence from lower Teesta basin in Bangladesh
Authors: Arfanuzzaman Md. , Hassan S. M. Tanvir , Syed Md. Abu
Published: January 2020

It is very likely that climate change will increase the frequency and intensity of extreme events such as floods, flash floods, storms, heat and cold waves, riverbank erosion, and drought in the river basin of Hindu Kush Himalayan (HKH) region. This could mean detrimental impacts to the poor and marginal people in the lower Teesta basin (LTB) in Bangladesh. Though adaptation involves financial costs, the farmers' practicing adaptation in LTB experience diminished crop loss and damage. This study was aimed at assessing the promising adaptation practices, their economic return, and social welfare in the LTB through an extended cost-benefit analysis. The study suggests that among the adaptations, shallow tube-well (STW) based irrigation practice in both sandy and loamy soil has the highest marginal adaptation cost (MAC) but the lowest benefit-cost ratio (BCR). The deep tube-well (DTW) based irrigation practice generates superior benefits to the farmers compared to the STW based farming due to initial establishment by the government which is very expensive. Maize farming as an alternate and less resource consumptive cropping produces nearly five times higher economic benefits than the costs which can be acknowledged as the most profitable and resilient adaptation option in the LTB. Though MAC is relatively low for the short-duration variety (SDV) rice among the promising adaptations, its economic profitability is 62% lower than that of the maize cultivation. However, having higher BCR the maize cultivation generates US$86 higher welfare to the farmers than the SDV rice which may strengthen the farmer's preference of maize cultivation over the SDV rice. It can be stated with high confidence that strategic adaptation planning, soft credit, technological advancement, and subsidized agricultural inputs will encourage the farmers to carry out adaptation options which may reduce climate-induced loss and damages for the farmers and build socio-economic resilience in the LTB and other similar areas of South Asia.
Upgrading water distribution networks to work under uncertain conditions
Authors: Marques J. , Cunha M.
Published: January 2020

This work presents a multicriteria approach to defining flexible solutions for reinforcing and renewing existing water distribution networks, considering uncertain future working conditions. Criteria related to financial, environmental and pipe failure assessment are proposed to evaluate alternative solutions and to identify the best-placed options to implement. The alternatives are obtained for a phased design scheme that enables midcourse corrections through changes in the network layout. The proposed framework has been demonstrated using a case study based on a water distribution network from the literature.
Implications for industrial application of bioflocculant demand alternatives to conventional media: waste as a substitute
Authors: Mohammed Jibrin Ndejiko , Wan Dagang Wan Rosmiza Zana
Published: January 2020

The biodegradability and safety of the bioflocculants make them a potential alternative to non-biodegradable chemical flocculants for wastewater treatment. However, low yield and production cost has been reported to be the limiting factor for large scale bioflocculant production. Although the utilization of cheap nutrient sources is generally appealing for large scale bioproduct production, exploration to meet the demand for them is still low. Although much progress has been achieved at laboratory scale, Industrial production and application of bioflocculant is yet to be viable due to cost of the production medium and low yield. Thus, the prospects of bioflocculant application as an alternative to chemical flocculants is linked to evaluation and utilization of cheap alternative and renewable nutrient sources. This review evaluates the latest literature on the utilization of waste/wastewater as an alternative substitute for conventional expensive nutrient sources. It focuses on the mechanisms and metabolic pathways involved in microbial flocculant synthesis, culture conditions and nutrient requirements for bioflocculant production, pre-treatment, and also optimization of waste substrate for bioflocculant synthesis and bioflocculant production from waste and their efficiencies. Utilization of wastes as a microbial nutrient source drastically reduces the cost of bioflocculant production and increases the appeal of bioflocculant as a cost-effective alternative to chemical flocculants.
Data-driven fault detection methods for detecting small-magnitude faults in anaerobic digestion process
Authors: Kazemi Pezhman , Giralt Jaume , Bengoa Christophe , Steyer Jean-Philippe
Published: January 2020

Early detection of small-magnitude faults in anaerobic digestion (AD) processes is a mandatory step for preventing serious consequence in the future. Since volatile fatty acids (VFA) accumulation is widely suggested as a process health indicator, a VFA soft-sensor was developed based on support vector machine (SVM) and used for generating the residuals by comparing real and predicted VFA. The estimated residual signal was applied to univariate statistical control charts such as cumulative sum (CUSUM) and square prediction error (SPE) to detect the faults. A principal component analysis (PCA) model was also developed for comparison with the aforementioned approach. The proposed framework showed excellent performance for detecting small-magnitude faults in the state parameters of AD processes.
Nível de aderência das empresas brasileiras listadas do setor de telecomunicações ao pronunciamento contábil CPC 47
Authors: Oliveira Rafael Xavier de , Crabbi Thais Mota , Rodrigues Jomar Miranda
Published: January 2020

Objetivo: O presente trabalho buscou analisar o nível de aderência (compliance) das empresas brasileiras do setor de telecomunicações listadas na B3 ao pronunciamento contábil CPC 47.
Metodologia: Foi elaborado um checklist contendo 8 (oito) critérios que as empresas deveriam divulgar para obter alto nível de compliance ao CPC 47. Caracteriza-se por ser uma pesquisa documental com análise de conteúdo junto às demonstrações financeiras consolidadas (balanço patrimonial e demonstração de resultado do exercício), notas explicativas e relatórios da administração divulgados pelas companhias nos anos de 2017 e 2018.
Resultados: Os resultados mostram que nenhuma empresa apresentou uma ampla aderência à nova norma. A empresa Telefônica Vivo Brasil foi a que apresentou maior nível, 56,25%, enquanto que a empresa Telebrás apresentou o menor, 29,16%. Adicionalmente, foi verificado se as empresas já divulgavam suas informações em conformidade à norma antes dela se tornar obrigatória, como forma de disclosure voluntário. As empresas OI S.A., Telebrás e Algar Telecom não apresentaram qualquer menção ao CPC 47 nos três primeiros trimestres do ano de 2017. Por outro lado, as empresas Telefônica Vivo Brasil e TIM Participações fizeram alusão à norma desde o primeiro período analisado.
Contribuições do Estudo: É um tema atual nas pesquisas em contabilidade, por ser o ano de implementação do CPC 47, e relevante, pois trará mudanças significativas nos critérios de reconhecimento e evidenciação das receitas. A partir da revisão bibliográfica, verificou-se poucos estudos tratando o tema. A partir disso, esta pesquisa buscou contribuir no sentido de ampliar o rol de trabalhos produzidos sobre o novo CPC, com uma abordagem quantitativa, nas linhas de evidenciação contábil e regulação.
Disclosure nos relatórios de sustentabilidade de empresas do novo mercado da Bovespa em consonância com os objetivos de desenvolvimento sustentável publicados pela ONU
Authors: Dos Reis Larissa , Rigo Vitor Paulo , Farinon Kemylli
Published: January 2020

Objetivo: O objetivo do estudo foi analisar se os relatórios de sustentabilidade divulgados pelas empresas, listadas no segmento do novo mercado da BOVESPA, estão alinhados com os objetivos de desenvolvimento sustentável publicados pela ONU.

Metodologia: Foi utilizada uma metodologia de abordagem descritiva, com acesso documental nos relatórios publicados pelas empresas no ano de 2016 e análise qualitativa dos resultados.

Resultados: Os achados da pesquisa, mostra que uma empresa apresenta evidências dos 17 objetivos propostos pela ONU e 7 das 29 empresas estudadas obtiveram mais de 50% de incidência das informações. Infere-se que as empresas não estão em consonância com os objetivos da ONU, pois nem todas as organizações estudadas evidenciam, as ações que tomam no decorrer do ano para cumprir os objetivos, a grande maioria somente cita os indicadores, ou menciona que está disposta a fazer, sem efetivamente dizer o que está sendo feito para a busca de um desenvolvimento sustentável.

Contribuições do Estudo: O trabalho é relevante, pois na atualidade as empresas buscam cada vez mais espaço no mercado, tornando as práticas organizacionais mais importantes tendo em vista a busca por recursos e consumidores. Com isso, há uma pressão maior para que as empresas atendam de forma sistemática, as dimensões econômica, social e ambiental da sustentabilidade, e como ferramenta para melhorar esse entendimento, é importante conhecer se as publicações dos relatórios de sustentabilidade das empresas estão em consonância com os objetivos da ONU. Contudo, os achados permitem compreender que há desafios importantes na divulgação de informações, pois, limites impostos pelas características, segmento do negócio e estrutura organizacional fazem com que determinados indicadores não sejam abordados pelas empresas. Em situações específicas, a organização não possui de fato, dados a serem compartilhados em relação a determinado objetivo, por isso, os dados quantitativos de divulgação, precisam ser avaliados com cautela.
O ensino de ciências contábeis e o processo de convergência ao international financial reporting standards
Authors: Bolzan Giovana , Vendruscolo Maria Ivanice , Sallaberry Jonatas Dutra , Diehl Willian
Published: January 2020

Objetivo: A pesquisa analisa o ensino de ciências contábeis diante da convergência aos padrões internacionais de contabilidade, sob a perspectiva da produção científica.
Metodologia: No estudo, a abordagem do problema ocorre de forma quali-quantitativa, quanto ao objetivo de forma descritiva e, no que tange aos procedimentos técnicos, a identificação de 21 artigos sobre “ensino” e “IFRS” no período compreendido entre os anos de 2007 a 2018, que foram suporte para a análise documental e revisão sistemática. No desenvolvimento da proposta empregou-se procedimentos de análise de conteúdo com a categorização dos trabalhos, e suas contribuições para a discussão.
Resultados: Os resultados evidenciam a preocupação com o currículo, os docentes e discentes no processo de ensino, em relação a percepção e à aquisição de conhecimentos. Foram identificados problemas e limitações tanto em discentes como em docentes, mas com resultados mais consistentes em períodos mais distantes do início da convergência aos padrões internacionais de contabilidade. No que tange às pesquisas, os principais pesquisadores do tema conjunto Ensino e IFRS, Jorge Niyama, Dulcinéli Botelho e Roberto Carlos Klann, e demais autores cujas publicações sobre o tema ocorreram em periódicos de elevada qualidade. Em geral, pesquisas sobre a temática permitem o desenvolvimento de redes com a predominância de pesquisadores doutores e com espaço para os demais pesquisadores em formação.
Contribuições do Estudo: O estudo ao revelar as dificuldades enfrentadas pelos docentes e discentes na incorporação dos novos preceitos contábeis e da assimilação do conhecimento, indica lacunas de necessidade de capacitação e de melhorias no processo de ensino a fim de ampliar a qualidade do ensino contábil. Além disso, sinaliza potenciais lacunas de pesquisa e demonstra que a temática absorve inclusive pesquisadores em formação em pesquisas conduzidas por doutores, denotando a importância dos grupos e das redes de pesquisa.
Evidenciación contable de las organizaciones sin fines lucrativos de asistencia social en Feira de Santana (BA): enfoque de acuerdo con las normas brasileñas de contabilidad
Authors: Acmar Feliz dos Santos de Santana  , Tânia Cristina Azevedo
Published: January 2020

Objetivo: el trabajo tenía como objetivo analizar la conformidad de la divulgación contable de las Organizaciones sin Ánimo de Lucro (en Brasil OSFL), poseedoras del Certificado de Entidad Benéfica de Asistencia Social (CEBAS) en Feira de Santana (BA), de acuerdo con las Normas Brasileñas de Contabilidad, y mediante la adopción de la Interpretación Técnica General – ITG 2002 (R1).

Metodología: se trata de un estudio cualitativo en cuanto al enfoque, realizado por medio de la investigación bibliográfica y documental. La etapa empírica de la investigación se realizó mediante un levantamiento de datos de las Entidades de Asistencia Social registradas en la página web del Ministerio de Desarrollo Social (MDS), seguido de la recogida de la información contable que allí se divulga y utilizando la estadística descriptiva para el tratamiento de los datos.

Resultados: la investigación demostró que el nivel de atención a la ITG 2002 (R1) puede ser considerado razonable, no obstante, los hallazgos de la investigación revelan que las áreas de gestión administrativo-financiera de las Entidades Benéficas de Asistencia Social (EBAS) no priorizan la elaboración y divulgación de la información contable para ser usada o para rendir cuentas a usuarios diversos.

Contribuciones del estudio: la contribución de la presente investigación reside en su fuente que está inspirada en las prácticas contables previstas en la ITG 2002 (RI) adoptadas por las EBAS, propiciando así el avance de futuras investigaciones en entidades que actúan en otros sectores.