bluuebunny/crossref_metadata_2025 huggingface dataset:
Rheumatic heart disease of the mitral valve alongside the papillary fibroelastoma of the aortic valve: A case report
Authors: Khezerlouy Aghdam Naser , Delkhah Mitra , Danayi Saeid , Sobhi Navid
Published: May 2024

Key Clinical Message

Besides thromboses, it's crucial to also consider the rare possibility of tumors like papillary fibroelastomas when evaluating worsening cardiopulmonary symptoms in patients with severe rheumatic mitral stenosis and atrial fibrillation.

Cardiac papillary fibroelastoma is a rare and benign endocardial tumor typically found on the aortic valve. The simultaneous occurrence of rheumatic heart disease affecting the mitral valve and papillary fibroelastoma on the aortic valve is infrequent, with limited documented instances. This unique case can enhance our understanding of the clinical presentation, diagnostic approaches, management options, and implications for patient outcomes in these two conditions. We present the case of a 47‐year‐old woman who was admitted to the hospital due to worsening dyspnea and fatigue, during which time she discovered an aortic valve papillary fibroelastoma. Further investigations revealed two thrombi in her left atrium and left atrial appendage, along with significant rheumatic mitral valve stenosis. The patient underwent thrombectomy, mitral valve replacement, and valve‐sparing aortic valve tumor resection. Following surgery, the patient's recovery was unremarkable. This case report emphasizes the need for a comprehensive evaluation in patients with rheumatic mitral stenosis, considering all possible etiologies. While thrombi are typical in mitral stenosis and atrial fibrillation, the rare presence of tumors like papillary fibroelastomas should be recognized, underscoring the importance of further assessment when suspicion arises. Importantly, individuals with asymptomatic cardiac papillary fibroelastomas should undergo surgical treatment to minimize the potential risk of tumoral embolization.
Response to regarding the case image article entitled “A case of angle‐closure glaucoma caused by spontaneous lens dislocation” by Kondo et al.
Authors: Kondo Keisuke , Isono Hiroki
Published: May 2024

Key Clinical Message

The occurrence of acute angle closure with posterior displacement of the lens is rare compared with that of anterior dislocation; however, several studies have reported its occurrence.
Dry needling in the management of chronic tension‐type headache associated with levator scapulae syndrome: A case report
Authors: Gagnon Peter , Dunning James , Bliton Paul , Charlebois Casey , Henry Nathan , Gorby Patrick , Mourad Firas
Published: May 2024

Key Clinical Message

The use of DN to the muscular trigger points and distal periosteal enthesis of the levator scapulae may be a useful adjunct intervention within a multi‐modal plan of care for the management of work‐related chronic tension‐type headaches associated with LSS.

Chronic tension‐type headaches (CTTH) have a lifetime prevalence of 42% and account for more lost workdays than migraine headaches. Dry needling (DN) is being increasingly used by physical therapists in the management of CTTH; however, to date, the supporting evidence is limited. The purpose of this case report was to describe how three sessions of DN targeting myofascial trigger points in the levator scapulae (LS) muscle and its distal enthesis was used to treat a 63‐year‐old male patient who presented with work‐related CTTH associated with levator scapulae syndrome (LSS). The patient was treated for five visits over the course of 2 months. At discharge and 6‐month follow‐up, the patient reported full resolution of symptoms. Self‐report outcomes included the numeric pain rating scale and the Neck Disability Index. The use of DN to the LS muscle and its distal enthesis may be a valuable addition to a multi‐modal plan of care in the treatment of work‐related CTTH associated with LSS.
Rhinorrhea and watery eyes in infancy and risk of attention‐deficit hyperactivity disorder in school‐age children
Authors: Perzanowski Matthew S. , Rauh Virginia , Ramphal Bruce , Acosta Luis , Hoepner Lori , Rundle Andrew G. , Perera Frederica P. , Herbstman Julie , Miller Rachel L. , Margolis Amy E.
Published: May 2024

Increased parasympathetic nervous system (PNS) activity is associated with attention‐deficit/hyperactivity disorder (ADHD) inattentive symptoms, but not hyperactive‐impulsive symptoms, and may contribute to inattentive subtype etiology. Guided by prior work linking infant rhinorrhea and watery eyes without a cold (RWWC) to PNS dysregulation, we examined associations between infant RWWC and childhood ADHD symptoms in a longitudinal cohort of Black and Latinx children living in the context of economic disadvantage (N = 301 youth: 158 females, 143 males). Infant RWWC predicted higher inattentive (relative risk [RR] 2.16, p < .001) but not hyperactive‐impulsive (RR 1.53, p = .065) ADHD symptoms (DuPaul scale), administered to caregivers at child age 8–14 years. Stratified analyses revealed that these associations were present in females but not males, who were three times more likely to have higher ADHD current total symptoms if they had infant RWWC than if they did not. Additionally, associations between RWWC and inattention symptoms were observed only in females. RWWC may thus serve as a novel risk marker of ADHD inattentive‐type symptoms, especially for females.
Nanodiamond‐Assisted High Performance Lithium and Sodium Ions Co‐Storage
Authors: Sun Xiaochen , Gao Xuan , Su Chang , Cheng Wei , Gao Nan , Zhang Xin , Gong Mengmeng , Dong Haobo , Dai Yuhang , He Guanjie , Li Hongdong
Published: May 2024

While lithium resources are scarce for high energy‐dense lithium‐ion batteries (LIBs), sodium‐ion batteries (SIBs), serving as an alternative, inherently suffer from low capacity and the high‐cost use of non‐graphite anodes. Combining Li‐ and Na‐ions within a single battery system is expected to mitigate the shortcomings of both systems while leveraging their respective advantages. In this study, we developed and assembled a nanodiamonds (NDs)‐assisted co‐Li/Na‐ion battery (ND–LSIB). This innovative battery system comprised a commercial graphite anode, an ND‐modified polypropylene (DPP) separator, a hybrid lithium/sodium‐based electrolyte, and a cathode. It is theoretically and experimentally demonstrated that the ND/Li co‐insertion can serve as an ion‐drill opening graphite layers and reconstructing graphite anodes into few‐layered graphene with expanding interlayer space, achieving highly efficient Li/Na storage and the theoretical maximum of LiC6 for Li storage in graphite. In addition, ND is helpful for creating a LiF‐/NaF‐rich hybrid solid electrolyte interface with improved ionic mobility, mechanical strength, and reversibility. Consequently, ND–LSIBs have higher specific capacities ~1.4 times the theoretical value of LIBs and show long‐term cycling stability. This study proposes and realizes the concept of Li/Na co‐storage in one ion battery with compatible high‐performance, cost‐effectiveness, and industrial prospects.
Forecasting corporate financial performance with deep learning and interpretable ALE method: Evidence from China
Authors: Liang Longyue , Liu Bo , Su Zhi , Cai Xuanye
Published: May 2024

Forecasting and analyzing corporate financial performance are of significant value to investors, managers, and regulators. In this paper, we constructed the one‐dimensional convolutional neural networks (1D‐CNN) and long short‐term memory (LSTM) deep learning models to investigate the feasibility of forecasting corporate financial performance with deep learning models, using the corporate financial features and environment, social and governance (ESG) rating index of Chinese A‐share listed corporation data from 2015 to 2021. Five evaluation metrics were employed to measure models' forecasting effects, and four competing machine learning models were built to verify the improvement in forecasting accuracy brought by the deep learning models. Furthermore, we also introduced the Accumulated Local Effects method to explore the forecasting processes of the deep learning models. The empirical results show the following: (1) Deep learning models can effectively extract the time‐series information in corporate data, thereby solving the task of predicting corporate financial performance with high accuracy. (2) The introduction of ESG information significantly contributes to the forecasting accuracy of corporate financial performance. For both 1D‐CNN and LSTM models, the ESG rating index can provide additional useful information for forecasting. (3) The interpretable results reveal the preference and emphasis of the two deep learning models for the different features. This further proves the robustness and reliability of deep learning models in forecasting corporate financial performance.
Data patterns that reliably precede US recessions
Authors: Leamer Edward E.
Published: May 2024

This paper proposes a method of forecasting US recessions beginning with data displays that contain the last 12 quarters of seven US expansions. These end‐of‐expansion displays allow observers to see for themselves what is different about the last year before recessions compared with the two earlier years. Using a statistical model that treats this historical data as draws from a 12‐dimensional multivariate normal distribution, the most recent data are probabilistically inserted into these images where the recent data are most like the historical data. This is a recession forecast based not on presumed patterns but on patterns revealed by the data.
Metabolomic analysis of dietary‐restriction‐induced attenuation of sarcopenia in prematurely aging DNA repair‐deficient mice
Authors: He Yupeng , Yang Wei , Huang Luojiao , Mever Marlien Admiraal‐van , Ramautar Rawi , Harms Amy , Rijksen Yvonne , Brandt Renata M.C. , Barnhoorn Sander , Smit Kimberly , Jaarsma Dick , Lindenburg Peter , Hoeijmakers Jan H. J. , Vermeij Wilbert P. , Hankemeier Thomas
Published: May 2024

Background

Sarcopenia is characterized by loss of skeletal muscle mass and function, and is a major risk factor for disability and independence in the elderly. Effective medication is not available. Dietary restriction (DR) has been found to attenuate aging and aging‐related diseases, including sarcopenia, but the mechanism of both DR and sarcopenia are incompletely understood.

Methods

In this study, mice body weight, fore and all limb grip strength, and motor learning and coordination performance were first analysed to evaluate the DR effects on muscle functioning. Liquid chromatography–mass spectrometry (LC–MS) was utilized for the metabolomics study of the DR effects on sarcopenia in progeroid DNA repair‐deficient Ercc1∆/− and Xpg−/− mice, to identify potential biomarkers for attenuation of sarcopenia.

Results

Muscle mass was significantly (P < 0.05) decreased (13–20%) by DR; however, the muscle quality was improved with retained fore limbs and all limbs grip strength in Ercc1∆/− and Xpg−/− mice. The LC–MS results revealed that metabolites and pathways related to oxidative‐stress, that is, GSSG/GSH (P < 0.01); inflammation, that is, 9‐HODE, 11‐HETE (P < 0.05), PGE2, PGD2, and TXB2 (P < 0.01); and muscle growth (PGF2α) (P < 0.01) and regeneration stimulation (PGE2) (P < 0.05) are significantly downregulated by DR. On the other hand, anti‐inflammatory indicator and several related metabolites, that is, β‐hydroxybutyrate (P < 0.01), 14,15‐DiHETE (P < 0.0001), 8,9‐EET, 12,13‐DiHODE, and PGF1 (P < 0.05); consumption of sources of energy (i.e., muscle and liver glycogen); and energy production pathways, that is, glycolysis (glucose, glucose‐6‐P, fructose‐6‐P) (P < 0.01), tricarboxylic acid cycle (succinyl‐CoA, malate) (P < 0.001), and gluconeogenesis‐related metabolite, alanine (P < 0.01), are significantly upregulated by DR. The notably (P < 0.01) down‐modulated muscle growth (PGF2α) and regeneration (PGE2) stimulation metabolite and the increased consumption of glycogen in muscle and liver may be related to the significantly (P < 0.01) lower body weight and muscle mass by DR. The downregulated oxidative stress, pro‐inflammatory mediators, and upregulated anti‐inflammatory metabolites resulted in a lower energy expenditure, which contributed to enhanced muscle quality together with upregulated energy production pathways by DR. The improved muscle quality may explain why grip strength is maintained and motor coordination and learning performance are improved by DR in Ercc1∆/− and Xpg−/− mice.

Conclusions

This study provides fundamental supporting information on biomarkers and pathways related to the attenuation of sarcopenia, which might facilitate its diagnosis, prevention, and clinical therapy.
High dose vitamin D supplementation decreases the risk of deficiency in male conscripts, but has no effect on physical performance—A randomized study
Authors: Rips Leho , Toom Alar , Kuik Rein , Varblane Ahti , Mölder Hanno , Kibur Ragnar , Laidvere Marika , Kull Mart , Kartus Jüri‐Toomas , Gapeyeva Helena , Rahu Madis
Published: May 2024

Purpose

Physical load during military training might increase the need for vitamin D; therefore, supplementation could be beneficial for 25(OH)D serum levels and physical performance.

Methods

One hundred and twelve male conscripts were randomized into two vitamin D oil capsule supplementation groups: 55 participants in the 600 IU group and 57 in the 4000 IU group with a follow‐up period from July 2021 to May 2022. Physical fitness tests were performed in July, October and May. Hand grip strength tests were performed in July, October and January. Blood serum (25(OH)D), parathyroid hormone PTH), calcium and ionized calcium (i‐Ca) values were measured in July, October, January and May.

Results

The 600 IU group had a lower (p < 0.001) value of 25(OH)D at all time points compared to the 4000 IU group, except at baseline. None of the subjects in the 600 IU group reached sufficient levels of 75 nmol/L of 25(OH)D in January and May. In May, 60% of participants in the 600 IU group and 30% in the 4000 IU group had 25(OH)D levels under 50 nmol/L. No significant differences in PTH or i‐Ca values were found between the study groups at any time point. No significant differences at any time point were found in the physical fitness test or hand grip strength test between the groups.

Conclusion

A 10‐month vitamin D supplementation with 4000 IU decreased the incidence of vitamin D deficiency (<75 nmol/L) in young, male army conscripts during wintertime, but no differences in physical performance were found compared to 600 IU supplementation.

Level of Evidence

Level I, Prospective randomized study.