bluuebunny/crossref_metadata_2025 huggingface dataset:
Nitric oxide synthase and endothelin-1 gene polymorphism in lower limb chronic venous insufficiency
Authors: Kalinin R E , Gryaznov S V , Nikiforov A A , Kamaev A A , Shvalb A P , Slepnev A A
Published: October 2016

Objective of this study was to evaluate the prevalence of endothelin-1 (EDN1 Lys198Asn) and nitric oxide synthase (NOS3 C786T) gene polymorphism in patients with lower limb chronic venous insufficiency; a possible correlation between gene polymorphism and degree of chronic venous insufficiency was also considered. The study included 240 patients with lower limb chronic venous insufficiency. The main group included 160 patients with venous ulcers; control group included 80 patients without ulceration. Peripheral venous blood samples were taken for DNA evaluation. EDN1 Lys198Asn mutation for endothelin-1 and NOS3 C786T mutation for nitric oxide synthase were studied. Detection of polymorphism in genes, which determine the development of endothelial dysfunction in lower limb chronic venous insufficiency, represents a useful tool to predict the severity of the disease and its outcomes.
The amylase test significance in the prediction of mortality of patients with necrotizing pancreatitis in the first three days of the disease onset
Authors: Politov S Y , Balnykov S I
Published: October 2016

The results of indicators blood amylase (160 studies) in the first three days of the beginning of a destructive pancreatitis in 149 patients in order to predict early mortality in the first 72 hours of onset. It was revealed that the enzyme values above 749 IU/L predicted an early death (sensitivity -Se. - 72,7%, specificity - Sp. - 71,8%). A more accurate forecast is based on a multifactor model cumulative effect of amylase, serum sodium concentration and the relative number of lymphocytes at the level of the associated criterion more «-2,52» (Se. - 71,4%, Sp. - 83,2%).
Results magnetic resonance spectroscopy on hydrogen in patients with metastatic lesions brain
Authors: Okolzin A V , Dergunov A V , Davydov V V , Toriya V G , Umantsev E I , Stepanishev I V , Martynov R S , Babichev K N
Published: October 2016

In our work, we were examined 18 patients with metastatic brain lesions. The resulting data provide an opportunity to study with the help of magnetic-resonance spectroscopy of hydrogen identify specific changes, occurring at the biochemical level in tissues of metastatic tumors compared to the contralateral unchanged substance of the brain.
Some bioactive coatings of implants (literature review)
Authors: Nazarov E A , Kuzmanin S A
Published: October 2016

The article considers possibilities of improvement of properties of coatings of implants through the introduction in their composition of germanium and diamond-like carbon components. Analyzed biological properties of inorganic germanium and its compounds. It is noted that germanium in the composition of the calcium phosphate coating of implants has a positive effect on the processes of osseointegration.
Dynamics of cardiovascular system on the test of physical performance in children of young school age with vision defects
Authors: Pavlova T V , Pilkevich N B , Pilkevich E A
Published: October 2016

The article is devoted to the study the dynamics of the work of cardiovascular system in children of young school age with vision pathology of tests for physical performance. Study was conducted among 85 children, aged from 7 to 10 years: including 48 boys and 37 girls, in which found that blind and poor-sighted children lag behind the children of the same age in terms of pulse pressure, systolic blood volume, actual and relative maximal aerobic power. Pulse tolerance limit, on the contrary, is higher than that of healthy children.
Experimental study of the activity of the hydrogel against burns with antihypoxant
Authors: Maksimenkova K I , Losenkova S O , Novikov V E
Published: October 2016

The article presents the results of an experimental study of the activity of the gel against burns with antihypoxant sodium poly(dihydroxyphenylen)thiosulfonate in a certain spectrum of doses. In the simulation of a thermal burn in male rats established that daily application on the wound once a day one strip of hydrogel with sodium poly(dihydroxyphenylen)thiosulfonate of size 1,5-2 cm with content 15 mg or 20 mg of drug substance provides high speed of epithelialization of wound for 16 days, unlike the control group and the intact, in which the complete healing is observed only at 29 days of the experiment. Applying of strip of cream "D Panthenol" of size 2 cm (the comparison group) provided a wound healing during the 26 days of observation.
Model development of HIV infection in the Republic of Tajikistan in the second decade of XXI century
Authors: Tursunov R A
Published: October 2016

The paper presents an assessment of the role of the transmission pathways in the development of the HIV epidemic in the Republic of Tajikistan (RT). Surveillance of HIV shows that in Tajikistan the deterioration of the epidemiological situation. As of 01.01.2015 in the country registered 6558 HIV-infected individuals (more than 1008 cases in comparison with 2013), of which: 4587 - 1971 men and woman. During the period 2002-2014 RT has been a steady downward trend in HIV transmission by injection: in 2004 - in 84,3% of cases of HIV infection occurred through injecting drug use, and in 2014 - in 48,2%, ie the specific weight of the transmission of the virus by the parenteral decreased 1.75 times. One of the significant factors of the spread of drug abuse in Tajikistan are drug trafficking and the presence of the drug industry in neighboring Afghanistan. Meanwhile, for the period 2009-2014 traced a clear a regular feature of the HIV epidemic in Tajikistan - a growing proportion of new HIV cases caused by unprotected heterosexual intercourse, indicating the activation of sexual transmission. The structure of the HIV pathogen sexual route of transmission was 26,5% in 2009, and in 2014 - 42,8%, ie, this figure increased by 1,6 times. Analysis of the features of the trends of the HIV epidemic in the Republic of Tajikistan and the comparative evaluation of the data obtained from similar works by other researchers suggest that both in our region and in the world in the second decade of the XXI century, depending on the importance of HIV transmission, formed a new model of development of the HIV epidemic.
Hygienic estimation of the functional state of the organism of medical personnel of maternity hospitals
Authors: Kotelevets E P , Kiryushin V A
Published: October 2016

The profound study of medical personnel working conditions of maternity hospitals made possible to conduct their hygienic estimation and find the degree of the influence of production process on the functional state of the workers organism in the dynamics of work shift and on the age aspect.
Chronic pancreatites or pancreatic ductal adenоcarcinoma?
Authors: Paklina O V , Setdikova G R , Chekmareva I A
Published: October 2016

Based on a comprehensive histological, immunohistochemical and ultrastructural study, the authors have developed criteria of histologic differential diagnosis between chronic pancreatitis and pancreatic ductal adenocarcinoma useful in doubtful cases, especially in core- biopsies and cryostat sections, as well as for novice doctors pathologists.
Selection of decompression bile ducts in the treatment of patients with obstructive jaundice of tumor genesis
Authors: Shabunin A V , Tavobilov M M
Published: October 2016

The paper studied the analysis of results of treatment of 349 patients with obstructive jaundice on the background of the pancreatic head tumor, treated at the Clinical Hospital named after S.P. Botkin in the period from 2010 to 2015. A study group included 159 patients who had biliary tract decompression performed by retrograde endobiliary stenting. The comparison group was 167 patients who underwent percutaneous transhepatic cholangiostomy under ultrasound guidance and Rg control. In the treatment of patients with tumors of the head of the pancreas and the phenomena of jaundice secondary to severe-stage method of treatment used. The first step was performed decompression of the biliary tract, thus reducing the jaundice, to stop the phenomenon of cholangitis, liver failure and to prepare the patient for the second phase - surgery. Analysis of the results showed that within the first 5 days from the moment of decompression of the bile ducts were observed significant difference in reducing bilirubin levels in groups 1 and 2. However, in the next 10 days had significantly more rapid decline as total bilirubin and enzymes of cholestasis (alkaline phosphatase) in a retrograde decompression process. Bacteriological examination of infected bile decompression observed in both the methods, however microflora bile patients during decompression antegrade more numerous and includes microorganisms skin and the environment. In applying the method of retrograde decompression of the bile duct postoperative complications is less than the antegrade fashion. In patients with obstructive jaundice due to periampulary zone tumor should be favored in a retrograde fashion when choosing a method of decompression of the bile ducts. In the absence of technical possibility of its implementation - decompression of the bile duct should be implemented antegrade manner.
Study of L-carnitine effect on the activity of cathepsins B, L, H, and oxidative modification of proteins in muscle organs of rats
Authors: Arapova A І , Fomina M A
Published: October 2016

We studied the influence of L-carnitine in a dose of 300 mg/kg on the aorta, myocardium and skeletal muscle of the anterior thigh of rats in isolation and in combination with regulators of the synthesis of nitric oxide: L-arginine, L-NAME. Activity of cathepsins B, L and H were studied by spectrofluorimeter method: in sedimentated and non-sedimentated fractions. Oxidative modification of proteins was evaluated by the method of R. L. Levine in modification of E. E. Dubinina. There was an inverse statistically significant strong correlation between the total area of modified proteins and non-sedimentated activity of cathepsin H in the area of the aorta under the action of the isolated carnitine at a dose of 300 mg/kg; and in the influence of L-NAME at a dose of 25 mg/kg, against the use of carnitine 300 mg/kg notes statistically significant strong direct correlation between change of total area оxidative modification of proteins and non-sedimentated activity of cathepsin L.
Characteristics оf child and adolescent suicide
Authors: Lukashuk A V , Filippova M D , Somkina O Y
Published: October 2016

The article is devoted to the review of modern domestic and foreign literature data concerning problems of suicidal activity among children and adolescents. The issues of the relevance of studying this problem, the prevalence in Russia and abroad, various variants of the formation of suicidal behavior, the role of the family in which educated teenager. The study of these issues in the future will allow you to create preventive techniques, effective therapeutic and preventive model of psycho-correction of detected violations and to identify the most relevant for therapy point of psychotherapeutic influence.
The alterations of neurophysiological parameters of the anterior cingulate cortex in the experimental depressive syndrome of different genesis
Authors: Abramets I I , Evdokimov D V , Zayka T O
Published: October 2016

The rostral anterior cingulate cortex (ACC) is important unit of the brain default mode network. An operation of this network is overset in depressive disorders of different genesis. A hyperactivity of ACC marks this overset. Neurophysiological nature of ACC hyperactivity do not elucidate. It was reproduced a behavioral depression in experiments on the rats evoke by either chronic inflammation of back skin or depletion of level of the monoamines in the brain administration of reserpine. The level of rat depression behavior estimated on the data of scores of forced swimming test. It was ascertained in electrophysi-ological researches on brain slices comprising ACC that depressogenic procedures evoked appearance of pathological synaptic plasticity (analog of the long-term potentiation) in superficial II/III layers pyramidal neurons. This pathological plasticity appeared by increasing of the amplitudes of field EPSPs and their AMPA and NMDA components; it was due by gain of the presynaptic glutamate releasing and possible rising of the postsynaptic receptors chemosensitivity. Pathological synaptic plasticity occluded tetanus-induced longterm potentiation in these layers of ACC. The neurophysiological changes in deep V layer of ACC were inconsiderable, however it was ascertained inhibition of tetanus-induced long-term potentiation expression.
Alcohol poisoning and epidemiological alcoholism parameters in Russia
Authors: Razvodovsky Y E , Zotov P B
Published: October 2016

A comparative analysis of trends in fatal alcohol poisonings and incidence of alcoholism and alcoholic psychoses was carried out. The results of distributed lags analysis suggest positive relationship between trends in fatal alcohol poisonings and incidence of alcoholic psychoses. The relationship between trends in fatal alcohol poisonings and incidence of alcoholism was also positive but statistically not significant. These findings suggest that alcoholic psychoses incidence rate is more reliable indicator of alcohol-related problems than alcoholism incidence rate.
Pathogenetic role in the allergic anamnesis development bronchitis in children
Authors: Pavlova T V , Pilkevich N B , Trophimova O A
Published: October 2016

Actuality in the structure of general morbidity of children, potential allergic markers of risk of developing bronchitis. The main group consisted of 62 children age from 1 to 6 years with obstructive and nonobstructive bronchitis. As a result of research it is established that allergies the first year of life increases the probability of developing obstructive bronchitis.
Polymorphism of genes for alcoholdehydrogenase, cysticfibrosis, pancreatic secretory trypsin inhibitor, a cationic trypsinogen in patients with chronic pancreatitis
Authors: Tarasenko S V , Bogomolov A Y , Nikiforov A A , Zaytsev O V , Natalskiy A A , Sokolova S N , Maksimova E S , Rachmaev T S , Kadykova O A
Published: October 2016

The study involved 63 patients with a verified diagnosis of chronic pancreatitis. In the 1st group included 31 patients with a complicated clinical forms of chronic pancreatitis, in 2st group included 32 patients with uncomplicated forms. The study analyzed the polymorphisms of genes PRSS1 (mutation R122H) - gene for cationic trypsingene, CFTR1 (mutation del508) - the gene for cystic fibrosis-1, CFTR2 (mutation Gly542Ter) - the gene for cystic fibrosis-2, SPINK1 (mutation N34S) - gene for pancreatic secretory trypsin inhibitor, gene ADH (ADH1B * 2). The study found a statistically significant correlation between ADH gene polymorphism and the risk of complicated forms of chronic pancreatitis.
Composite material based on calcium phosphate and germanium (experimental study)
Authors: Kuzmanin S A , Nazarov E A , Vesnov I G
Published: October 2016

In the experiment conducted biomechanical tests to determine the coupling forces 4 groups of implants with the bone tissue: No. 1 was made of medical steel, No. 2 was made of titanium alloy VT6 with the modified surface by using the method of the thermo-chemical treatment. No. 3 and No. 4 were made of titanium alloy VT6 with composite coating (calcium phosphate + 1% and 5% germanium, respectively), applied by the method of microarc oxidation. Implants were installed in the proximal femur of purebred cats (29 animals). Upon removal of animals from the experiment (after 3 months) conducted static tests. Noted that the bond strength in 3 and 4 groups of implants with the bone tissue is more pronounced than in groups 1 and 2.
REVIEW OF POST-MORTEM INVASIVE AND NON-INVASIVE METHODS TO STUDY THE PATHOLOGY OF GREAT VESSELS OF FETUSES AND NEWBORNS
Authors: Zhakota D A , Korchagina N S , Vorozhbieva T E , Tumanova E L , Mnihovich M V , Nechaev L V , Gallyamova A R
Published: October 2016

The article presents the current methods of postmortem morphometric study great vessels fetuses and infants, taking into account the requirements and technical capabilities in vivo diagnosis of congenital diseases of the cardiovascular system - MRI, echocardiography and other.
SOCIO-HYGIENIC PROBLEMS OF IMPLEMENTATION OF A MODERN SYSTEM OF SECONDARY PROFESSIONAL EDUCATION OF ADOLESCENTS
Authors: Kazaeva O V
Published: October 2016

In article socially-hygienic perspective, consider the questions of the system of secondary vocational education modernization as an integral part of transforming socioprofessional structure of modern Russian society. Were analyzed and the dependence of modernization and status of settings mid-level professionals in the labour market and factors of reproduction of this professional group in modern conditions.
THE STRUCTURAL AND FUNCTIONAL STATE OF THE C-CELLS OF THE THYROID GLAND IN HYPOPHYSECTOMIZED ANIMALS
Authors: Rakhmankina V A , Tsareva O A
Published: October 2016

The ultrastructure of the C-cells of the thyroid gland in hypophysectomyzed rats was studied. Morphometric studies of the nuclear apparatus and cytoplasm with organelles C-cells were held at the ultrastructural level. Nuclear-nucleolar ratio and the ratio of euchromatin and heterochromatin were studied in experiment. Area euchromatin increased in the nucleus. The amount of cristae in mitochondria and the average area of mitochondria were estimated to study the energy of C-cells and the energy efficiency ratio compartment was calculate on the basis of morphometric data. The number of mitochondria is increased in the cell. The number of cristae is increased in mitochondria. The energy efficiency ratio compartment increases. Degranulated form of C-cells predominant. The ultrastructural changes indicating C-cells hyperfunctional condition on the background of the thyroid hormone function were discovered.
APPLICATION SCANNING MICROSCOPY TO STUDY REPARATION A BONE FABRIC
Authors: Bashuk I P , Pavlova T V , Pavlova L A , Nesterov A V , Pilkevich N B
Published: October 2016

For studying of regenerative-reparative processes a bone fabric of a skull of rats implants from nanostructure the titan with various kinds of a covering were used. For an estimation of results were used optical, electronic microscopy, the trace element analysis. It is established that use nanocomposites considerably accelerated processes of regeneration of a bone fabric of a skull in difference from use titanum without a covering.
INFLUENCE OF VILDAGLIPTIN AND GLIQUIDONE COMBINATION ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY AND EXPRESSION ON THE BACKGROUND OF NORM AND IN EXPERIMENTAL ALLOXAN-INDUCED DIABETES MELLITUS TYPE 2
Authors: Yakusheva E N , Titov D S , Nikiforov A A
Published: October 2016

In the in vivo study on rabbits investigated the effect of the vildagliptin and gliqui-done combination on the background of norm and experimental alloxan-induced diabetes mellitus (DM) type 2 on the P-glycoprotein (P-gp, ABCB1 protein) functional activity and its expression in the tissues of the jejunum, liver, kidney and the blood-brain barrier. Introduction of combination of vildagliptin at a dose of 5 mg/kg and gliquidone 10 mg/kg body weight on the background of norm for 14 days did not result in P-glycoprotein changes. On the 5-day of the cancellation of this combination observed inhibition of transporter protein functional activity without altering its expression. In the combination therapy of vildagliptin and gliquidone alloxan-induced diabetes type 2 showed complete recovery of P-glycoprotein functional activity and expression reduced on the pathology background. On the 5-day of treatment withdrawal again occurred inhibition of functional activity of the transporter protein and a decrease in its expression.
CONGENITAL COMPLETE HEART BLOCK IN PREGNANT WOMEN: A MULTIDISCIPLINARY APPROACH TO DIAGNOSTICS AND TREATMENT
Authors: Kalinin R E , Suchkov I A , Mzhavanadze N D , Shitov I I , Povarov V O
Published: October 2016

Treatment options in patients with complete congenital heart block (atrioventricular block of III degree) may be controversial. Major obstacles are faced in pregnant women with newly detected heart block. Type of arrhythmia, presence of hemodynamic instability or syncope, anatomy of heart chambers and vessels, gestational age significantly influence the treatment. This article presents substantial information on etiology, pathogenesis, diagnostics, and possible treatment options in pregnant women with complete congenital heart block.
THE MEDICATION INHALE TECHNOLOGY AND ASTHMA CONTROL
Authors: Rogachikov A I , Uryasev O M
Published: October 2016

The article presents a study of the influence of inhalation technology on the control of bronchial asthma (BA). The study involved 59 patients with asthma in the full or partial control, the definition of the complaints, the number of errors when inhaled through a metered aerosol inhaler indicators of respiratory function, levels of exhaled nitric oxide. Following the training sessions on the art of inhalation after 4 weeks again, a repeated examination. Decrease the number of points detected by questionnaire form ACQ-5, which corresponds to an increase in asthma control and also reduce errors by inhalation medicaments by metered-dose inhaler.
Routines of Writing: Administration and the Poetics of Movement in Robert Walser’s Works and the Film All This Can Happen
Authors: Roloff Simon
Published: October 2016

This article contextualizes Robert Walser’s The Walk and All This Can Happen through Walser’s literary practice and the social technologies of his time. It is argued that walking, perceiving, and writing in both works become part of a quasi-bureaucratic routine and therefore reflect certain historical changes in the office as an architectural and technical means of administration. Walser’s earlier novel Jakob von Gunten is referred to in order to expand the argument and develop the final thesis that Walser’s poetics of movement mirror an administrative control of “life” that was strongly shaped and remodelled around 1900.
Addendum to Interview: All This Can Happen on Tour and in the Press
Authors: Kappenberg Claudia
Published: October 2016

This document lists over 80 screenings of All This Can Happen between September 2012 and July 2016. The list is evidence of the international interest the film generated and indicates the different contexts in which it was shown during its first four years. Most are screenings, often in the context of festivals, whereas others—much less frequently—exhibitions. The hosts vary between explicit screendance events, film festivals, art venues, and educational frameworks. For example, in Berlin’s doku.arts festival, All This Can Happen was screened alongside Mike Lerner und Maxim Posdorowkin’s documentary “Pussy Riot: A Punk Prayer” in a programme of films which transgress conventional narratives. The diverse contexts demonstrate that the boundaries between local and international communities and institutions are relatively porous and that films can travel widely. A second list of press reviews, existing review essays and selected blog entries on the film give a sense of audience reception and complement this review.
The Mighty Walser: From a Short Story by Robert Walser, a Choreographer and Director Have Made a Mesmerizing Piece of “Perambulatory Poetics.”
Authors: Sandhu Sukhdev
Published: October 2016

By Christmas Day 1956, when his frozen body was found by schoolchildren in a field of snow near the asylum where he had resided for more than twenty years, the Swiss writer Robert Walser had been largely forgotten. There had been a time when the failed actor and former butler, born in 1878, was well known among Europe’s literary intelligentsia: Robert Musil, Herman Hesse, Stefan Zweig, Franz Kafka, and Walter Benjamin all admired his short stories and novels. During the 1920s, though, he was increasingly afflicted by hallucinations. In 1933 he entered a sanatorium, announcing: “I am not here to write, but to be mad.”[i][i] Middleton, introduction, 12.
Trauma and Dissociation in All This Can Happen
Authors: Morin Ross
Published: October 2016

This paper is a close textual reading of Siobhan Davies and David Hinton’s experimental film, All This Can Happen, as an exploration of the causes, symptoms, and coping methods associated with posttraumatic stress disorder (PTSD) in returned soldiers. The paper argues that the film repurposes Robert Walser’s short story, The Walk, as an autobiographical account of the mental illness that plagued the author later in his life. The paper examines the connections between the narrated text and the onscreen imagery to identify diagnostic criteria of PTSD (as characterized in the American Psychological Association’s Diagnostic and Statistical Manual for Mental Disorders, 5th Edition) such as dissociation, panic, depression, psychological and physiological triggers of flashbacks, avoidance behavior, hyper vigilance, and recurrent and intrusive thoughts. The paper concludes with an analysis of the film’s split-screen editing technique, arguing that the experimental form of the film places the viewer deeper into the psychology of the narrator and functions to garner greater empathy and understanding of his pain.
IJSD Volume 7 2016 All This: Full Issue
Authors: Kappenberg Claudia , Whatley Sarah , Bench Harmony , Ellis Simon
Published: October 2016

The full issue of IJSD vol. 7 (2016).Please note: For the best offline reading experience, please print double-sided on 8.5x11 paper. Links to online sources are live in the PDF if read onscreen.
Estudio comparativo de eficacia entre dos pañales para la prevención y tratamiento de la dermatitis por pañal
Authors: Sáez de Ocariz Gutiérrez María del Mar , Díaz García Luisa , Contreras Verduzco Francisco Alberto , Narváez Rosales Verónica , Solís Ortiz Dulce , Greenawalt-Rodríguez Sydney , Espinosa Padilla Sara , Orozco Covarrubias Luz
Published: October 2016

INTRODUCCIÓN: una meta a alcanzar en los niños que usan pañal es mantener una piel intacta dentro del área cubierta por éste y así evitar la dermatitis por pañal.OBJETIVO: comparar la eficacia de dos tipos de pañal para prevenir o tratar la dermatitis por pañal.MATERIALES Y MÉTODOS: ensayo clínico aleatorizado en lactantes de 6 a 12 meses de edad, con o sin dermatitis por pañal, que utilizaron pañales Huggies UltraConfort® o BBTips®. Se investigó la presencia o ausencia de dermatitis por pañal y la evaluación de la eficacia del pañal por el médico y el cuidador. El análisis estadístico incluyó análisis uni- y bivariado.RESULTADOS: en el grupo sin dermatitis por pañal se evaluaron 68 lactantes con edad promedio de 8.54 ± 2.09 meses. Había tenido eventos previos de dermatitis por pañal 72%. Catorce lactantes tuvieron dermatitis por pañal. La comparación entre ambos tipos de pañal demostró que BBTips® fue más eficaz que Huggies UltraConfort ®. En el grupo con dermatitis por pañal se evaluaron 66 pacientes con edad promedio de 8.65 ± 2.4 meses. Había tenido eventos previos de dermatitis por pañal 88%. A los 15 días se habían resuelto 53% de las dermatitis por pañal y al mes 88%. La comparación entre ambos tipos de pañal no demostró diferencias significativas en la eficacia.CONCLUSIONES: en el aspecto preventivo BBTips® fue superior a Huggies UltraConfort®. Ambos pañales tuvieron eficacia similar en el tratamiento de la dermatitis por pañal.
Prevención de neumonía asociada a ventilación con paquete de verificación en la Unidad de Cuidados Intensivos. Estudio piloto
Authors: Hernández Orozco Hilda Guadalupe , Castañeda Narváez José Luis , Lucas Reséndiz María Esperanza , Rosas Ruiz Aurora , Aparicio Santiago Guadalupe Leticia , Zárate Castañón Patricia , Camacho Soto Silvia Andrea
Published: October 2016

INTRODUCCIÓN: los paquetes de verificación son una estrategia efectiva para la prevención de neumonías asociadas a ventilador.OBJETIVO: determinar la viabilidad y beneficios de aplicar un paquete de verificación para prevenir neumonías asociadas a ventilador.MATERIAL Y MÉTODOS: estudio piloto transversal, ambispectivo realizado del 2011 al 2013, determinando la tasa de neumonías asociadas a ventilador por 1,000 días ventilador en ese periodo y aplicando a partir del 2012 un paquete de verificación, para prevenir neumonías asociadas a ventilador en niños con ventilación mecánica en la Unidad de Cuidados Intensivos Pediátricos.RESULTADOS: el cumplimiento de los parámetros evaluados mediante el paquete de prevención de neumonías asociadas a ventilador implementado en 2012 fue de entre 66 y 100%, con una disminución en la incidencia de neumonías asociadas a ventilador de 47% en el periodo 2011 a 2012 y de 69% en 2013, con tasas de neumonía asociada a ventilador de 13.85, 7.29 y 4.3 neumonías por 1,000 días ventilador, respectivamente.CONCLUSIONES: el uso de paquete de verificación para prevención de neumonías es aplicable y efectivo para disminuir estas infecciones asociadas a la atención de la salud. Implica el compromiso y trabajo multidisciplinario de todo el servicio, así como un programa para llevar a cabo esta estrategia, por lo cual se planea su aplicación en todas las unidades de cuidados intensivos de la institución.
Life-changing makeovers through dermatology
Authors: Office Editorial
Published: October 2016

Dr. Raffaele Rauso’s journey in Aesthetic Medicine
Introducing JSD’s new associate editor
Authors: Office Editorial
Published: October 2016

Dr. Felipe Bochnia Cerci: Soaring to greater heights in dermatology
Dermoscopy: Where are we?
Authors: Aghaei Shahin
Published: October 2016

JSD Volume 1, Issue 3 Editorial
Zeal for dermatology leads the way
Authors: Office Editorial
Published: October 2016

Raising awareness and finding the cure for skin cancer
O papel dos professores/educadores ambientais e seus espaços de formação. Qual é a educação ambiental que nos emancipa?
Authors: Freire Laísa , Figueiredo João , Guimarães Mauro
Published: October 2016

Neste artigo, sistematizamos as discussões realizadas pelo Grupo de Discussão de Pesquisa - Pesquisa em Educação Ambiental (EA) e a Formação de Educadores(as)-Professores(as), no VIII EPEA. Partimos de indagações sobre a formação de professores(as) e educadores(as) ambientais em EA e sobre o que significa formar um(a) educador(a) ambiental crítico. Construímos eixos de discussão que permitiram a construção coletiva de reflexões sobre os espaços de formação de professores(as)/educadores(as) ambientais e construção de uma identidade; sobre a legitimação de espaços de formação do(a) educador(a) ambiental na universidade e sobre a formação em pesquisa do(a) educador(a) ambiental. Concluímos que um dos caminhos possíveis é a formação crítica e dialógica, que se propõe a reconhecer o(a) educador(a) ambiental em formação como autor(a) de sua própria formação e de sua trajetória como alguém que elabora seu próprio conhecer na relação com outros seres.
Caminhos e dilemas da educação ambiental no contexto escolar
Authors: Oliveira Araujo Maria Inêz , Andrade Modesto Mônica , Ferreira Santos Tatiana
Published: October 2016

O presente artigo tem como finalidade apresentar as questões elencadas no GPD Educação Ambiental no Contexto Escolar, refletir sobre o que foi identificado e apresentar os encaminhamentos que possam indicar contribuições para os pensares e fazeres que constituíram os caminhos e dilemas, nas apresentações e debates presenciados durante os dois dias de discussão, durante o VIII Encontro de Pesquisa em Educação Ambiental. As questões apresentadas no grupo abordaram temas como: aspectos teórico-metodológicos, currículo, políticas públicas, formação de professores, educação ambiental crítica e programas implementados no contexto escolar. Sobre as pesquisas realizadas, a de intervenção foi a mais utilizada. Ao final, foram explanados encaminhamentos coletivos que têm como elemento fundante a esperança pela abertura de mais caminhos no que diz respeito à educação ambiental.
Health Inequalities in Diabetes Mellitus and Hypertension: A Parish Level Study in the Northern Region of Portugal
Authors: Leao Teresa , Perelman Julian , Felício Manuela , Machado Vasco , Lima Graça
Published: October 2016

Introduction: Diabetes and hypertension are highly prevalent conditions in Portugal. Little is known about the geographical and social patterning of these diseases, which precludes the design of targeted health policies. This study aimed to measure the geographical and socioeconomic distribution of type 2 diabetes and hypertension prevalence in the population resident in the Northern region of Portugal, for the year 2013.Material and Methods: An ecological correlation study analyzed the 2,028 parishes of the region. Prevalence data were obtained from the Regional Health Administration information system. Socioeconomic data were also obtained from this administrative database and from the 2011 national census. The association between each socioeconomic indicator and age-standardized prevalence was measured using the difference in prevalence, population attributable risk, relative inequality index, and regression coefficient.Results: The prevalence of type 2 diabetes and hypertension was 6.16% and 19.35%, respectively, and varied across parishes. These prevalences were significantly associated with low educational level, low tertiary sector weight, unemployment, and low-income rate (with prevalence differences between the most and least advantaged deciles up to 1.3% and 5.3%, respectively). Socioeconomic factors accounted for up to 20% of prevalence.Discussion: This study design did not allow us to evaluate causality and it may underestimate these diseases prevalence or its association with socioeconomic factors, but its results are in line with the evidence from other countries.Conclusion: These results emphasize the socioeconomic and geographical patterning of major diseases associated with a high mortality, and the need of health policies targeting the most deprived parishes.
Cardiopatia Congénita em Crianças com Síndrome de Down: O que Mudou nas Últimas Três Décadas?
Authors: Dias Filipa Mestre A. , Cordeiro Susana , Menezes Isabel , Nogueira Graça , Teixeira Ana , Marques Marta , Abecasis Miguel , Anjos Rui
Published: October 2016

Introdução: A prevalência da síndrome de Down tem aumentado nos últimos 30 anos; 55% destas crianças apresentam cardiopatia congénita.Material e Métodos: Estudo retrospetivo longitudinal de coorte; dados clínicos obtidos em bases de dados de 1982 a 2013 com o diagnóstico de síndrome de Down ou trissomia 21 num hospital de referência em cardiologia pediátrica e cirurgia cardíaca.Objetivo: Avaliar a evolução, nas últimas três décadas, dos cuidados cardiológicos prestados às crianças com síndrome de Down ecardiopatia congénita.Resultados: Estudámos 102 doentes com síndrome de Down e cardiopatia congénita submetidos a terapêutica invasiva: cirurgiacardíaca corretiva, paliativa e cateterismo terapêutico. Em doentes referenciados no primeiro ano de vida, a referenciação foi cada vez mais precoce. O diagnóstico mais frequente foi o defeito completo do septo aurículo-ventricular (41%). Verificou-se uma tendência para cirurgia corretiva cada vez mais precoce em doentes abaixo dos 12 meses (p < 0,001). A partir de 2000, a grande maioria dos doentes foi operada antes dos seis meses de idade. As principais complicações cardíacas foram alterações de ritmo e baixo débito e as principais não cardíacas foram pulmonares e infeciosas. A taxa de mortalidade a 30 dias foi de 3/102 casos (2,9%). Dos doentes em follow-up, 89% estão em classe funcional I da NYHA.Discussão e Conclusão: A correção cirúrgica mais precoce verificada nos últimos 15 anos vai ao encontro do proposto na literatura. A taxa de mortalidade a 30 dias verificada é sobreponível aos resultados internacionais. Os doentes com síndrome de Down submetidos a cirurgia corretiva de cardiopatia congénita apresentam uma excelente capacidade funcional a longo prazo.
Low Adherence to Mediterranean Diet in Portugal: Pregnant Women Nutrition in Portugal and its Repercussions
Authors: Pereira-da-Silva Luis , Pinto Elisabete
Published: October 2016

Introduction: Portuguese population is drifting away from the Mediterranean diet-like pattern. In this context, the current nutritionalstatus of women of childbearing age and of pregnant Portuguese women and their growing fetuses is critically reviewed.Material and Methods: A narrative critical review was performed on recent published high quality studies assessing diet and nutritional status of women of childbearing age and pregnant women and its influence on the nutritional status of their offspring.Results: Data from five multinational ecological studies that included Portugal, two national official surveys on food availability, seven national studies on the diet and nutritional status of women of childbearing age and pregnant women, and five national studies on the effect of nutritional maternal factors on their growing fetuses were selected and analyzed. The prevalence of overweight/obesity has dramatically increased in Portuguese women of childbearing age and pregnant women, associated with the described trend of low adherence to Mediterranean diet. Variations in energy and macronutrients intakes during pregnancy seem to have no significantly impact on the nutritional status of growing fetuses. On contrary, pre-pregnancy overweight/obesity has been associated with increased offspring adiposity at birth, and an excessive gestational weight gain may be associated with offspring’s overweight status in childhood. Factors potentially contributing to low adherence to the Mediterranean diet, deserving further investigation, include European Union agriculture policies that have implemented the production of non-Mediterranean food groups at low cost, and insufficient financial capacity to afford foods of quality reported by Portuguese population.Conclusion: Retrieving traditional Mediterranean dietary habits should be incorporated into strategies for prevention and treatment ofoverweight/obesity in Portugal, especially in women of childbearing age.
Phenotypic Heterogeneity by Germline Mismatch Repair Gene Defect in Lynch Syndrome Patients
Authors: Hernâni-Eusébio Jorge , Barbosa Elisabete
Published: October 2016

Introduction: Lynch syndrome is the most common form of hereditary colorectal cancer, being also responsible for endometrial and other types of cancers. It is associated with germline mutations in DNA mismatch repair genes and microsatellite instability. MLH1 and MSH2 mutations have a “classical” Lynch syndrome phenotype, with MSH2 having a higher association with extracolonic cancer. MSH6 and PMS2 mutations have an atypical phenotype. Clinical expression is heterogeneous, with correlation between mismatch repair mutated gene and phenotypic patterns.Material and Methods: We retrospectively analyzed data from patients fulfilling Amsterdam criteria or having mismatch repair gene mutations, between September 2012 and October 2015.Results: We identified 28 patients. Seventeen had colorectal cancer with right colon predominance. Five developed endometrial cancer (median age of diagnosis – 53), with no MSH6 mutations. Five developed other cancers. All mutated mismatch repair cases studied had microsatellite instability.Discussion: Most cases had MSH2 mutations despite MLH1 being described in the literature as the most frequently mutated. Interestingly, colorectal cancer patients showed no tendency for high inflammatory infiltrate. Despite the high incidence of synchronous and metachronous tumours, most patients underwent a partial colectomy. Prophylactic hysterectomy and adnexectomy was performed in menopausal/perimenopausal patients.Conclusion: A standardized registration of patient’s data may lead to better management and knowledge about Lynch syndrome. Use of Bethesda Guidelines might identify new cases non-identified by Amsterdam criteria. Microsatellite instability analysis must be performed in a much larger scale. The genotypic/phenotypic correlation described in the literature was not verified in our study with statistical significance, perhaps due to small data sample and insufficient clinical registration.
A Genética nos Cuidados de Saúde Primários: Uma Perspetiva Multidisciplinar
Authors: Magalhães Sara , PANEQUE Milena , Silva João
Published: October 2016

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A reafirmação do Projeto Ético-Político do Serviço Social: um desafio urgente
Authors: Carvalho Fabiana Aparecida de
Published: October 2016

O presente artigo reflete a necessidade urgente e contemporânea acerca da reafirmação do Projeto Ético-Político da categoria do Serviço Social. Através da participação de alguns fóruns de articulação profissional de base, como reuniões de comissões de conselhos de direito, grupo de estudos e eventos de formação profissional, como palestras e seminários em diversos municípios de diferentes Estados brasileiros, deparei-me com inúmeras assistentes sociais que questionam a legitimidade do Projeto Ético-Político, bem como do próprio Código de Ética da profissão. Trata-se de um evento que destaca um movimento paradoxal entre a academia e a base profissional. Nesse sentido, propõe-se o convite à (re)visitação a esses princípios e à reafirmação dos mesmos. Compreendendo assim, que a práxis profissional deve alcançar a práxis social e materializar-se em lutas políticas em favor de um novo modelo societário, que não seja o capitalismo e a sua insaciável sede de lucro e mais valia. Um modelo que não justifique suas crises capitais para adensar a miséria de muitos seres humanos. Abstract: This article reflects the urgent and contemporary about the reaffirmation of the ethicalpolitical project of the category of Social Work. Through participation in some forums to articulate professional basis, including meetings of committees of boards of law, the study group and training events such as lectures and seminars in various cities of different states of Brazil, I came across numerous social workers who question the legitimacy of the Ethical Political Project, as well as the Code of Ethics of the profession. This is an event that highlights a paradoxical movement between academia and professional basis. Accordingly, it is proposed to call for (re) visitation to the reaffirmation of these principles and the same. Understanding then, that professional practice must achieve social praxis and effect in political struggles in favor of a new corporate model, that is not capitalism and its insatiable thirst for profit and added value. A model that does not justify their attacks to capital deepening the misery of many humans.
Entrevista
Authors: SS&S Equipe , Santos Cláudia Mônica dos
Published: October 2016

Entrevista com autores institucionais: Cláudia Mônica dos Santos
Anotações cronológicas sobre a trajetória do serviço social no sistema de saúde em Portugal
Authors: Guadalupe Sónia
Published: October 2016

O presente artigo sistematiza em breves notas cronológicas alguns passos do caminho de alargamento e consolidação do espaço profissional do Serviço Social no sistema de saúde em Portugal. As anotações aqui apresentadas pretendem contribuir para organizar os principais marcos históricos e legislativos, do período que decorre entre 1924 e 2010, atravessando um percurso que centramos no Serviço Social em articulação com o contexto sociopolítico nacional e global em que se insere.
Matricialidade sociofamiliar: compromisso da política de assistência social e direito da família
Authors: Gueiros Dalva Azevedo , Santos Thais Felipe Silva dos
Published: October 2016

Este artigo busca refletir sobre matricialidade sociofamiliar em termos conceituais e em sua operacionalidade em espaços referenciais de assistência social, situando-se na articulação entre os fundamentos teórico-metodológicos advindos do Serviço Social e a prática profissional. Discute as famílias contemporâneas e suas questões, sobretudo aquelas que dependem da atenção do Estado para promover o cuidado e a proteção a seus membros. Nesse sentido, parte-se do entendimento de que a situação presente de famílias socialmente vulnerabilizadas é fruto de percursos sociais complexos, resultantes da desigualdade social e de transformações no mundo do trabalho e nas relações de gênero, entre outros aspectos. A partir de informações empíricas coletadas entre assistentes sociais, adentra-se à análise de aspectos que norteiam a intervenção profissional em Centros de Referência de Assistência Social, e toma-se como pressuposto que uma proteção social efetiva requer o acesso de todos a direitos sociais.
O serviço social e a consolidação de direitos: desafios contemporâneos
Authors: Martinelli Maria Lúcia
Published: October 2016

O objetivo deste ensaio é trazer para a reflexão algumas questões relativas aos desafios contemporâneos que se colocam para o Serviço Social no que se refere à consolidação dos direitos sociais consagrados pela Constituição Federal de 1988 e referendados pelo projeto ético-político da profissão. Tomando por referência analítica a categoria identidade, examino os desafios que se colocam para o exercício profissional e finalizo com algumas proposições, tendo em vista a consolidação do referido projeto.
Serviço social e humanização: experiência da residência em saúde - Universidade Federal do Triângulo Mineiro – UFTM
Authors: Rodrigues Andreia Cristina , Silva Ivone Aparecida Vieira da , Aguiar Karen Costa , Farinelli Marta Regina , Rezende Regina Maura , Martins Rosane Aparecida de Sousa , Melo Suely Aparecida Alberto , Conti Verena , Santos Zilda Cristina dos
Published: October 2016

A humanização tem sido associada a diferentes e complexas categorias relacionadas à produção e gestão de cuidados em saúde, tais como: integralidade, satisfação do usuário, necessidades de saúde, qualidade da assistência, gestão participativa, protagonismo dos sujeitos, além de uma assistência capaz de prover acolhimento, resolutividade, e ainda, visar à melhoria da qualidade de vida dos sujeitos. Discutir o trabalho do assistente social na área da saúde com enfoque na Política de Humanização nos remete a algumas características que desvendam a particularidade desse complexo processo de trabalho, no qual o Serviço Social é historicamente e culturalmente identificado como uma das profissões da saúde que tem se dedicado às questões relativas à humanização do atendimento. Este artigo propõe a reflexão acerca da experiência do Serviço Social na Residência Multiprofissional em Saúde tendo como premissa o compromisso com o reconhecimento da saúde como resultante das condições de vida, derivadas das condições econômicas, políticas, sociais e culturais da população. A partir desta experiência videnciou-se a relevância do Serviço Social paraequipe multiprofissional no sentido de contribuir para a articulação, identificação e produção de informações acerca da realidade social marcada pelas contradições que se traduzem na desigualdade que desumaniza, subtrai e ainda, exclui. O assistente social tem o compromisso ético-político de trazer para o espaço institucional a informação, o conhecimento e o saber desconhecido pela população usuária, corroborando assim para a edificação de seu projeto ético político profissional bem como para o fortalecimento das ações voltadas para a humanização em saúde.