bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Strategies to Promote Circular Economy in the Management of Construction and Demolition Waste: A Case Study in Manaus, Brazil
Authors: Oliveira Maria do Perpétuo Socorro Lamego , de Oliveira Evailton Arantes , Fonseca Ana
Published: May 2021

Construction and Demolition Waste (CDW) cause environmental impacts in a worldwide scale. The existing international concern regarding the adequate management of CDW is justified by the large amount of this waste produced in a daily basis, together with its potential hazardous effects on ecosystems and human health. In countries with growing economies, like Brazil, it is of the utmost importance to promote sustainability-oriented practices that can co-exist with economic development. In this scope, the present research proposes strategies regarding the management of CDW based on the Circular Economy principles, focusing the case study of the municipality of Manaus, in the centre of the Amazon Forest. The characterization of the reference situation regarding CDW management in Manaus revealed several deficiencies, namely the lack of reuse and recycling opportunities, the unsupervised disposal of CDW in illegal landfills, together with insufficient surveillance procedures and inadequate policies from regional authorities like the Manaus City Hall and the Amazon’s Regional Council of Engineering and Agronomy (CREA-AM). The acknowledgement of these problems led to the identification of improvement opportunities and to the development and operationalization of Circular Economy promotion strategies: valorisation of CDW through the enhancement of reuse and recycling opportunities, operationalized through a mobile phone application; inclusion of sensibilization and surveillance practices regarding professional activities related to CDW management on the CREA-AM inspection plan; and the proposal of alterations in the municipal policies regarding CDW disposal in the public landfill. These strategies have been implemented in the Manaus municipality, but are easily adaptable to other Brazilian municipalities and even to other countries’ realities.
Distribution of Crystalloid Fluid Infused During Onset of Anesthesia-Induced Hypotension: A Retrospective Population Kinetic Analysis
Authors: Hahn Robert G
Published: May 2021

Background. Loading with crystalloid fluid before induction of anesthesia is widely practiced but cannot reduce the accompanying drop in arterial pressure. The aim of this report is to provide a mathematical view of how fluid distributes in this setting.Methods. Data were retrieved from three studies where 76 patients (mean age 63 years, mean body weight 66 kg) had received approximately 1.1 L of Ringer’s solution over 60 min by intravenous infusion before and during induction of spinal, epidural, or general anesthesia. A population kinetic model was used to analyze the fluid distribution and its relationship to individual-specific factors. Frequent measurements of blood hemoglobin and the urinary excretion served as dependent variables.Results. Before anesthesia induction, distribution to the extravascular space was 3-fold faster than elimination by urinary excretion. Both distribution and elimination of infused fluid were retarded in an exponential fashion due to the anesthesia-induced decrease in the mean arterial pressure (MAP). A decrease in MAP from 110 to 60 mmHg reduced the rate of distribution by 75% and the rate of elimination by 90%. These adaptations cause most of the infused fluid to remain in the bloodstream. Age, gender, type of anesthesia, and the use of ephedrine had no statistically significant effect on plasma volume expansion, apart from their possible influence on MAP.Conclusion. The decrease in MAP that accompanies anesthesia induction depresses the blood hemoglobin concentration by inhibiting both the distribution and elimination of infused crystalloid fluid. The report provides mathematical information about the degree of these changes.
Can the Olive Genome Be a Miracle for Human DNA?
Authors: ŞENKAL Muhammet , Akalin Ibrahim
Published: May 2021

We aimed to compare the human genome with the olive genome on the hypothetical context of whether or not any human-plant genomic alignment similarities could give rise to genomic bioavailability when consumed likewise carbohydrates, proteins, fats. Many studies from past to present have shown beneficial effects of olives on cardiovascular diseases and some cancer pathways. Moreover, scientific and even religious resources highlighted the importance of the olive. In our project, we aligned the olive genome with the human genome in Pubmed Blast database.
We detected several genes has had 100 percent matching sequences where pathological and non-pathological variations were identified in the human genome. Interestingly wild type variations were observed in the olive genome and those matching regions were consuming restriction sites. In our data, matching regions at cardiovascular and cancer-related genes could suggest a possible bioavailability of plant genomes even in vitro. Further studies, comparing other plant genomes with the human genome would beget more promising results.
In vitro biofabrication of silver nanoparticles: Optimization, characterization, and activity against beta-lactamases-resistant Enterococcus faecalis
Authors: Fattah Bikhal , Arif Huner , Hamzah Haider
Published: May 2021

The rate at which nosocomial infections have spread throughout the globe has been alarming. Therefore, the data presented here sheds light on some aspects of AgNPs as promising anti-infective therapy. However, knowledge on the safe usage of AgNPs in the field of medicine is necessary to investigate. AgNPs synthesis, optimization, characterization, and mode of action against Enterococcus faecalis have been studied in this paper. We propose a combination of cell-free supernatant (C-FS) of the intimate organisms; Fusarium solani and Comamonas aquatica as synthesis catalysts. The optimization findings were at pH 9.0 for 72 h in 1 mM AgNO3 using 1:2 v/v (C-FS : AgNO3). UV-vis absorption peak appeared at 425 nm and the crystalline nature of synthesized particles was verified by XRD. FTIR analysis confirmed the presence of protein molecules that acted as reducing and stabilizing agents. Energy-dispersive X-ray analysis exhibited an intense peak at 3 KeV, confirming the formation of AgNPs. Further, FE-SEM images prove AgNPs synthesis. TEM and AFM analysis demonstrated that fabricated AgNPs were relatively monodispersed, approximately spherical, and of size 2-7.5 nm. The growth and biofilm of nosocomial E. faecalis were significantly decreased by the action of AgNPs. Furthermore, antibiotic resistance genes, blaTEM, and blaCTX, were detected in E. faecalis; both genes were degraded enormously via 9 % AgNPs. This is the first study proposing alternative sources to form AgNPs via synergistic metabolites of F. solani and C. aquatica. The results here offer a foundation for developing an effective therapy using AgNPs against nosocomial pathogens.
In-Situ X-Ray Tomography on Permeability Evolution of C/SiC Porous Ceramic for Hypersonic Vehicles
Authors: Zhang Bo , Huang Haiming , Wu Shengchuan , Li Weijie , Huang Jie , Lin Andi , Wu Qian , Liu Yuexun , Xiao Tiqiao
Published: May 2021

Transpiration cooling system in hypersonic vehicles still remains a challenge due to the limitations of observing permeability and microstructure evolution of porous medium filled with coolant. To tackle this problem, a novel compression-permeation device is designed with high-resolution X-ray tomography system, and then an investigation on permeability evolution mechanism of a C/SiC porous ceramic under pressure is performed using in-situ X-ray imaging and the compression-permeation device. The experimental results indicate that the pore-space fluid flow is displayed in terms of three-dimensional streamlines, making the permeability mechanism clear. Meanwhile the porosity along the thickness of ceramic under pressure has been obtained by synchrotron tomography testing, and it is also verified that the porosity of C/SiC ceramic fabricated in our research group is basically uniform (>95.4%) along the thickness. Furthermore, we have found the evolution rule for permeability of porous ceramic with water, which depends on the variation of its microstructure under different loads.
Activation of mtor Mediates Hyperglycemia-Induced Renal Glomerular Endothelial Hyperpermeability via the RhoA/ROCK/pmlc Signaling Pathway
Authors: Chen Jianhui , Li Xianfan , Chen Xiaolin , Yu Zengpu
Published: May 2021

OBJECTIVE: Hyperglycemia is associated with albuminuria and renal glomerular endothelial dysfunction in patients with diabetic nephropathy. The mTOR and RhoA/ROCK signaling pathways are involved in glomerular filtration barrier (GFB) regulation, but their role in high glucose (HG)-induced GFB dysfunction in human renal glomerular endothelial cells (HRGECs) has not been investigated. This study aimed to investigate the mechanisms of HG-induced GFB dysfunction in vitro.MATERIALS AND METHODS: HRGECs were cultured in vitro and exposed to HG. The horseradish peroxidase–albumin leakage and transendothelial electrical resistance of the endothelial monolayer were measured after HG treatment with or without rapamycin preincubation. A fluorescence probe was used to study the distribution of F-actin reorganization. The phosphorylation levels of myosin light chain (MLC) and mTOR were measured via western blotting. RhoA activity was evaluated via GTPase activation assay. The effects of blocking mTOR or the RhoA/ROCK pathway on endothelial permeability and MLC phosphorylation under HG conditions were observed.RESULTS: HG exposure induced F-actin reorganization and increased MLC phosphorylation, leading to EC barrier disruption. This effect was attenuated by treatment with rapamycin or Y-27632. Phospho-MLC (pMLC) activation in HRGECs was mediated by RhoA/ROCK signaling. mTOR and RhoA/ROCK inhibition or knockdown attenuated pMLC activation, F-actin reorganization and barrier disruption that occurred in response to HG exposure.CONCLUSIONS: Our results revealed that HG stimulation upregulated RhoA expression and activity through an mTOR-dependent pathway, leading to MLC-mediated endothelial cell cytoskeleton rearrangement and glomerular endothelial barrier dysfunction.
Making Sense of a Pandemic: Mindsets Influence Emotions, Behaviors, Health, and Wellbeing During the COVID-19 Pandemic
Authors: Zion Sean , Louis Kengthsagn , Horii Rina , Leibowitz Kari , Heathcote Lauren , Crum Alia
Published: May 2021

As the SARS-COV-2 virus spread across the world in the early months of 2020, people sought to make sense of the complex and rapidly evolving situation. This longitudinal study of N=5,365 Americans assessed three mindsets people formed about the COVID-19 pandemic and what it meant for their lives: ‘the pandemic is a catastrophe’, ‘the pandemic is manageable’ and ‘the pandemic can be an opportunity’. In line with our pre-registered hypotheses, these mindsets were associated with a unique and largely self-fulfilling pattern of emotions (positive, negative), behaviors (healthy, unhealthy, and compliance with CDC guidelines), experiences (connection/growth, isolation/meaninglessness) and wellbeing (physical health, mental health, quality of life). Moreover, mindsets formed in the first week of the pandemic predicted quality of life 6 months later, an effect that was mediated by emotions and behaviors.
Multi-sensor biologgers and innovative training allow data collection with high conservation and welfare value in zoos
Authors: English Holly M , Harvey Luke , Wilson Rory P , Gunner Richard M , Holton Mark D , Woodroffe Rosie , Börger Luca
Published: May 2021

Zoos are valuable resources for research, providing scientists with access to rare and elusive species in an easy to observe environment. Animal-attached loggers (aka biologgers) offer profound insight into animal behaviour. Their use in zoos has high yet largely untapped potential to collect data relevant for wild animal research and conservation but also welfare and enrichment monitoring of the zoo animals themselves. However, affixing biologgers to study animals can be problematic in captive settings, limiting the accessibility of this technology for use on zoo species which ordinarily need to be sedated for the fitting of such devices, including large carnivores. Here we show that biologging collars and crate-training allow collection of novel datasets on captive animals with high welfare and conservation value, using endangered African wild dogs (Lycaon pictus) tagged with tri-axial accelerometer and tri-axial magnetometer loggers, as a case study. Two yearling female wild dogs were fitted with biologging collars while sedated in preparation for translocation from London to Whipsnade Zoo, with data collected for 10–26 hours until collar detachment. Two adult male wild dogs at London Zoo were trained to accept collars in a modified crate in exchange for a food reward, which allowed fitting and detaching the collars without sedation, with data collected for 28 days. First, we show how accelerometer and magnetometer data allow detection of fine-scale individual differences in the recovery from sedation as well as within- and between-individual variation in activity patterns in relation to the type of food received (tong vs. rabbit and pony carcass). Using the vectorial dynamic body acceleration metric (VeDBA), a proxy for movement-related energy expenditure, further shows that daily energy expenditure was higher on days with partial pony carcass feeds compared to rabbit feeds but varied considerably between days where flesh pieces were fed with tongs. Using the dead-reckoning method allowed reconstruction of fine-scale (1 Hz locations) movement paths within enclosures, indoors and outdoors, allowing visualisation and quantification of fine-scale movement and space use differences between individuals and over time, for example in response to different enrichment methods. Using multi-sensor biologgers, combined with training captive animals to accept collars without the use of anaesthetic, can enable flexible, experimental approaches to data collection with minimal impact on study animals, providing novel understanding of relevance for both zoo and wild animals.
Prediction of infection risk associated with the dynamic behavior of aerosol particles during dental aerosol generating procedures in dental clinics in the context of the COVID-19 pandemic
Authors: Baldion Paula Alejandra , Guerrero Camilo Alejandro , Cruz Alberto Carlos , Rodríguez Henry Oliveros , Betancourt Diego Enrique
Published: May 2021

Background: The health emergency declaration owing to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has drawn attention toward nosocomial transmission. The transmission of the disease varies depending on the environmental conditions. Saliva is a recognized SARS-CoV-2 reservoir in infected individuals. Therefore, exposure to fluids during dental procedures leads to a high risk of contagion. Objective: This study aimed to develop an infection risk prediction model for COVID-19 based on an analysis of the dynamic behavior of aerosol particles generated during dental procedures. Materials and methods: The dispersion of aerosol particles during dental aerosol-generating procedures (AGPs) performed on phantoms was evaluated using colored saliva. The gravity-deposited aerosol particles were registered using filter paper within the perimeter of the phantom head and the settled particles were recorded in standardized photographs. Digital images were processed to analyze the stained area and the drops dimensions. A logistic regression model was built with the variables ventilation, distance from the mouth, instrument used, area of the mouth treated, and location within the perimeter area. Results: The largest percentage of aerosol particles ranged from 1 to 5 µm. The maximum settlement range from the mouth of the phantom head was 320 cm, with a high-risk cut-off distance of 78 cm. Ventilation, distance, instrument used, area of the mouth being treated, and location within the perimeter showed association with the amount of aerosol particles. These variables were used for constructing a scale to determine the risk of exposure to aerosol particles in dentistry within an infection risk prediction model. Conclusion: Contamination by disseminated aerosol particles represents a risk for the dental staff. Thus, it is advisable to improve ventilation and use biosafety measures. The need to implement new clinical and educational strategies was evident. This model is useful for predicting the risk of exposure to COVID-19 in dental practice.
ENVIRONMENTAL TAXATION IN UKRAINE: PROSPECTS OF IMPROVEMENT BASED ON FOREIGN EXPERIENCE
Authors: Zakharkina L. , Novikov V.
Published: May 2021

Today, scientists are paying particular attention to the problems of low efficiency of environmental taxation due to ineffective tax policies, lack of incentives to modernize production, low tax revenues to local budgets, and further growth of environmental pollution. In this context, it is rational to study the European experience of implementing environmentally friendly tax policy, which is relevant for Ukraine. The purpose of the study is to identify the shortcomings of the domestic tax system related to the negative impact on the environment, analysis of European environmental tax instruments and their practical effectiveness, analysis of the possibility of using foreign experience in the practice of domestic environmental taxation. Methods of comparison, structuring, grouping, and systematization were used in the research process. The article provides a comparative analysis of existing environmental taxes in the European Union and Ukraine during 2010-2019. The study found that the environmental tax burden in Ukraine is much lower than in the EU, which demonstrates a lack of understanding of the importance of environmental protection for businesses, the lack of adequate institutional mechanisms for control and responsibility in this area. A rating assessment of the system of environmental taxes has been developed, which considers the indicators of their environmental and economic efficiency and ease of collection. The criteria of the studied indicators are environmental and economic efficiency, the stability of environmental revenues, the possibility of tax evasion, administrative costs, social and political popularity. The need to use such indicators is due to the complexity of the assessment and its importance for both the environment and the socio-economic sphere. Based on the constructed matrix of distribution of environmental taxes, it was established that the tax that is the easiest to manage and most consistent with the value of environmental and economic efficiency is the environmental tax for air emissions of pollutants from stationary sources. Analysis of the experience of EU countries allows us to draw the following conclusions: conditions should be created to stimulate business to transition to environmentally friendly means of production by obtaining preferential credit resources, establishing a progressive taxation system in case of excessive pollution of the ecosystem.
DEBT SECURITY AS AN IMPORTANT ELEMENT OF UKRAINIAN'S ECONOMIC SECURITY SYSTEM
Authors: Husakovska T. , Shymanovska-Dianych L. , Rybalko-Rak L.
Published: May 2021

Debt security is an important factor influencing the national economy, which determines the nation ability to sustainable socio-economic development. Debt security has a key impact on national economic security, ie on the country's ability to withstand and reduce the debt yoke, to preserve financial and economic sovereignty. The constant transformation and the necessary identification of the factors of development of the national economy significantly actualizes the research aimed at ensuring the economic security of the nation and, in particular, its component – debt security.
The aim of the research is a comprehensive analysis of the essence of the concept of debt security as an important element of the economic security of Ukraine and the establishment of key features of debt security through general scientific methods and research methods – analysis and synthesis, induction and deduction, integrated and systematic approach, historical and scientific abstraction, logical analysis. The article analyzes scientific approaches to the category of economic security and proves the need to identify such a structural element as debt security of the nation, explores the essence of the category of debt security and identifies its key features – complexity and systematics, relativity, stability, which improves methodological and applied management methods, when establishing objects of management within the system of debt security of the nation. The structure of the nation and nation-guaranteed debt of Ukraine as of January 31, 2021 is described. The global financial crisis has shown that existing vulnerabilities caused by rising debt need to be addressed through the development of an effective debt management system, taking into account the relationship between debt security and financial stability. Problems of debt security in the Ukrainian economy, the search for methods, tools and strategies to ensure sustainable economic sovereignty of Ukraine require further research in this area of research.
THEORETICAL ASPECTS OF CONTROLLING IN THE ENTERPRISE MANAGEMENT SYSTEM
Authors: Onishсhenko M. , Dutchenko O. , Kotiuk R.
Published: May 2021

The article deals with the theoretical aspects of controlling in the enterprise management system. The paper proves the need to use the concept of controlling as an effective tool for enterprise management. The main reasons for the need to use controlling in enterprises are outlined.
Recently, large enterprises have shown considerable interest in controlling as one of the systems of successful enterprise management. Studies at enterprises have shown that the use of controlling technology in the management process has increased the efficiency of management.
Today, controlling is an effective management tool in enterprises. Based on the collected and analyzed available information, controlling allows to predict the future state. Controlling is becoming more and more important and necessary every day, because it allows you to adjust the plans and goals of the company to changing environmental conditions based on such predictions.
Controlling allows you to constantly monitor the achievement of both strategic and operational goals of the enterprise.
The scope of this concept is both the external and internal environment of the organization, and its main objectives include ensuring the stability of the enterprise, anti-crisis measures and prevention of bankruptcy.
The main reasons for the need to use controlling in enterprises are outlined. The main functions and subsystems of controlling at the enterprise are defined. Controlling provides a methodological and instrumental framework to support the basic functions of management: planning, control, accounting and analysis, as well as assessment of the situation for management decisions.
Controlling is designed to help the company effectively use the existing potential and create new conditions for successful operations in the future. Controlling in the strategic sphere acts as an "internal consultant" to senior management and owners of the business entity in setting strategic goals and objectives and their achievement.
It is proved that the controlling system forms a system of effective enterprise management and provides coordination of the management system as a whole, which in turn reduces the time spent on management decisions.
Determination of cyber accessibility of teacher made tests/exams
Authors: ÖZDEMİR Gülden , ÖZDEMİR Atilla , GELBAL Selahattin
Published: May 2021

This study aims at determining the cyber accessibility of teacher-made exams by analyzing the teachers’, students’, and parents’ views on this subject. To fulfill this purpose, 60 exam papers in 4 different courses, including Turkish, Mathematics, Science, Social Studies/Atatürk’s Principles and Revolutions, were examined through the technique of document analysis. Also, nine teachers, nine students, and nine parents were interviewed through semi-structured interview forms. According to the results, the level of cyber accessibility of secondary school teacher-made exams were; 87% for Turkish, 51% for mathematics, 99% for Science, and 88% for Social Studies/Atatürk's Principles and Revolutions courses. The highest level of cyber accessibility was found in multiple-choice and open-ended questions for Turkish courses, true-false questions for mathematics courses, open-ended, true-false, matching, and gap-filling questions for the Science courses and open-ended questions for Social Studies/Atatürk’s Principles and Revolutions courses. Students and parents stated that they make use of cyber accessible websites while preparing for teacher-made exams. On the other hand, teachers indicated that they perceived themselves incompetent in assessment and evaluation.
Brak wiary a wykluczenie godności sakramentalnej małżeństwa
Authors: Leszczyński Grzegorz
Published: May 2021

The Code of Canon Law of 1983 classifies the reasons for marriage invalidity in three different categories: diriment impediments, defects in matrimonial consent and lack or defect of canon form. Among different defects in matrimonial consent, in 1101 § 2, Code of Canon Law enumerates simulations. Simulation signifies that a person contracting marriage expresses marital agreement merely on the surface, excluding in reality through a positive act of the will the marriage itself, some essential elements or an essential property of marriage. The present article is an attempt of looking at the relation existing between the validity of marriage and the exclusion of the sacramental dignity, with the special consideration of the faith of the person.
Relacja nauczania papieża Franciszka zawartego w adhortacji Amoris laetitia do dotychczasowego posoborowego Magisterium
Authors: Młot Jarosław
Published: May 2021

The apostolic exhortation Amoris laetitia, issued by Pope Francis on April 8, 2016, is the fruit of as many as two synodal sessions. The great interest in the subject of these synods, not only in Church circles, resulted from the expectations of some for a change in the position of the Church's discipline in the admission of the divorced and remarried persons to Communion. The publication of the exhortation caused a lot of discussion among scientists and priests alike. The article is only an attempt to indicate the subject of these discussions. The statements of people regarding the relation of the teaching contained in Amoris laetitia to the current post-Conciliar Magisterium can be divided into those that express doubts about the texts of this document and those that read it in the key of the hermeneutics of continuity. The article attempts to show the most important directions of interpretation of the exhortation. The Pope did not intend the exhortation as a document containing general norms applicable in all cases. That is why he set the bishops of individual regions of the world to create guidelines for this exhortation that would be adequate to the traditions and calls of their region. The article describes some sample local documents. The discussion merely outlined in the article and the differences in the interpretation of the exhortation texts shown in it show the need for further study on it.
Ochrona danych osobowych świadków w sprawach o stwierdzenie nieważności małżeństwa kanonicznego
Authors: Poniatowski Michał
Published: May 2021

W artykule zostało przedstawione zagadnienie dotyczące ochrony danych osobowych świadków w sprawach o stwierdzenie nieważności małżeństwa kanonicznego.

W pierwszej kolejności przedstawiono ochronę danych osobowych w Kościele. Ochrona ta może być regulowana prawnie w ramach autonomii Kościoła. Ochrona danych osobowych w Kościele ma charakter obowiązku i nie stanowi to novum w kościelnym porządku prawnym.

W dalszej części artykuł przedstawiono problematykę uznania autonomii i niezależności Kościoła w zakresie przetwarzania danych osobowych. W tym zakresie wskazano na relację norm prawa kanonicznego i prawa świeckiego.

Artykuł zawiera również przedstawienie ochrony danych osobowych świadków mając na uwadze to czy są oni członkami Kościoła czy też nie. Kwestia ta ma odpowiednie skutki prawne w zakresie ochrony danych osobowych.

Najważniejsze wnioski przedstawiono w zakończeniu.
Wezwanie sądowe i prawo do obrony
Authors: Gałkowski Tomasz
Published: May 2021

The study concerns the cases the author encountered in the Diocesan Tribunal when one of parties presents a petition for declaration of nullity of a marriage. The petitioner sometimes gives the other party’s false address, or even sometimes gives an address where he/she can collect the citation himself/herself. The author considers several possibilities of appealing against the sentence in such cases and analyzes the possibility of invoking the reasonable doubt as to validity of the sentence in the cases where the denial of the right of defense occurs.
Prediction of Inhibition Activity of BET Bromodomain Inhibitors using Grid Search-Based Extreme Learning Machine and Molecular Docking
Authors: Oyeneyin Oluwatoba Emmanuel , Obadawo Babatunde Samuel , Orimoloye Segun Michael , Akintemi Eric Oluwafisayo , Ipinloju Nureni , Asere Adeola M. , Owolabi Taoreed O.
Published: May 2021

Background:

Inhibition activity of the epigenetic readers, such as bromodomain and extra-
C terminal domain protein family, is of high significance in many therapeutic applications due to
their ability to regulate gene expression as well as the chromatin structure by binding to acetylysine
residues.

Objectives:

In order to effectively and quickly determine the inhibition activity of these compounds
for the desired therapeutic application, this work presents a grid search-based extreme learning machine
computational intelligence method through which the inhibition activity of forty different
compounds of substituted 4-phenylisoquinolinones was determined.

Methods:

The prediction and generalization capacity of the developed model were assessed using
four different error metrics, which include root mean square error, mean absolute error, mean absolute
percentage deviation, and correlation coefficient between the measured values and predicted
activities. The lead compound (37), together with a kinase inhibitor, LY294002, and a bromodomain
and extra-C terminal inhibitor, CPI-0610, was docked with a bromodomain-containing protein 4
bromodomain 1, 6P05.

Results:

The developed model performed better than the existing model with percentage improvement
of 44.48%, 35.08%, 20.44%, and 1.23% on the basis of mean absolute percentage deviation,
mean absolute error, root mean square error, and correlation coefficient, respectively. The lead compound
has a better binding score than LY294002 and CPI-0610.

Conclusion:

Implementation of the developed model would help in searching for anti-inflammatory
as well as anticancer agents for effective therapeutic application.
Current Status, Opportunities and Challenges of Green Corrosion Inhibitors
Authors: Kundu S.
Published: May 2021

The term ‘Corrosion’ is associated with the deterioration of materials. To get rid of this problem corrosion inhibitors are commonly used. Though many conventional corrosion inhibitors can efficiently reduce corrosion, their disposal often adversely affects the environment. However, there are many natural products that have the potential of reducing corrosion and they are referred to as green corrosion inhibitors. They are much safer to use and most importantly cost-effective. This chapter deals with the current development of the use of green corrosion inhibitors, their opportunities and challenges.
Методика измерения сечений многофотонного поглощения лазерных импульсов в газах с помощью спектрофона
Authors: Куряк А.Н. , Тихомиров Б.А.
Published: May 2021

A technique to measure cross section of multiphoton absorption of laser pulses in gases using photoacoustic detector with time resolution of signals (a spectrophone) has been developed. The efficiency of the technique was tested on the example of single-photon and three-photon absorption of nanosecond pulses of quasimonochomatic radiation with a wavelength of 266 nm by molecular oxygen.
Гибридный двухкомпонентный бризер
Authors: Адамашвили Г.Т.
Published: May 2021

Рассмотрено нелинейное когерентное взаимодействие света с диспергирующей и керровской средой, содержащей оптические примесные атомы или полупроводниковые квантовые точки. Используя обобщенную версию метода пертурбативного разложения, нелинейное волновое уравнение сводится к связанным нелинейным уравнениям Шредингера. Показано, что производные второго порядка играют существенную роль в описании процесса образования связанного состояния двух бризеров, которые осциллируют на суммарной и разностной частотах и волновых числах. Резонансные, нерезонансные и гибридные механизмы формирования двухкомпонентного бризера, реализуются в зависимости от параметров света и вещества. Приведены явные аналитические выражения для профиля и параметров нелинейного импульса. Обсуждаются условия формирования резонансных, нерезонансных и гибридных нелинейных волн. В частном случае, резонансный векторный бризер совпадает с векторным 0π-импульсом самоиндуцированной прозрачности. Ключевые слова: гибридные нелинейные волны, самоиндуцированная прозрачность, двухкомпонентный бризер
The Effect of Morphologies of Embedded Plasmonic Cu-nanoparticles on Solar Absorption of Perovskite Solar Cells: A Comprehensive Study-=SUP=-*-=/SUP=-
Authors: Sahai Shreya , Varshney Anshu
Published: May 2021

In this work, we aim to reduce the production costs of Perovskite solar cells (PSCs) and achieve high solar absorbance with the inclusion of different shapes of plasmonic nanoparticles within its 200 nm thick Perovskite layer. We have performed an extensive study based on the different morphologies of plasmonic nanoparticles including nanospheres, nanocubes, nanocylinders, nanorods, nanotriangular plates embedded within the film. This geometric study is extended to the different orientations of a particle within the film, with respect to the source of light. Based on our previous study involving different materials of nanoparticles within the perovskite film, copper is selected as a potential candidate to drastically reduce the production costs without compromising the absorption efficiency of the cell. Varying sizes of these copper nanoparticles are placed at the centre of the film to verify the enhancement of the light trapping efficiency of these designed cells. We find that the absorption efficiency of PSCs highly depends upon the corner sharpness and orientation of a nanoparticle within the film, though the average absorption remains analogous to the spherical particles. Since the designed PSC with tailored nanoparticles portray a significant variation in its absorbance efficiency with the change in its geometrical parameters, hence we can choose a specific morphology of the particle, placed at a certain angle within the film to obtain maximum absorbance. The entire study is based on the Finite Difference Time Domain (FDTD) method of simulation. Keywords Perovskite solar cells, solar absorbance, plasmonic Nanoparticles, FDTD
A Digital Mobile Community App for Caregivers in Singapore: Predevelopment and Usability Study
Authors: Lwin May O , Sheldenkar Anita , Panchapakesan Chitra
Published: May 2021

Background

With increasing life expectancy and aging populations, the global prevalence of chronic diseases and the long-term care required for people with comorbidities is rising. This has led to an ever-growing need for caregiving. Previous literature has shown that caregivers face problems of isolation and loneliness. However, many health organizations mainly focus their efforts on in-person community groups that require participants to meet physically. This is not always convenient or accessible for caregivers who are often juggling caring for their care recipient with family and work responsibilities.

Objective

With medical advancements such as the proliferation of mobile phones and internet technology, caregivers may have opportunities for easier access to resources and support. Technological innovations could help empower the caregiving community to seek assistance for improving their quality of life at their convenience. A community network app called Caregivers’ Circle was conceptualized in response to the needs of the caregivers on a day-to-day caregiving journey. This paper traces the predevelopment inquiry and technical details of this app to provide a clear understanding of its implementation along with a usability study to gauge user opinion of the app within Singapore.

Methods

A predevelopment survey was conducted to identify specific needs of caregivers and gaps in the currently available web-based community networks. The survey consisted of questions on demographical data, health-related issues of the care recipient, mental and physical health–related issues of the caregiver, digital media use, information seeking, and support. This pre–app development survey was completed by 103 caregivers. Qualitative enquiries were also conducted with caregivers within Singapore to identify issues related to caregiving, support provided, and what caregivers would want from a caregiving mobile app.

Results

From the feedback garnered from the caregivers, the developers were able to identify several caregivers’ needs and gaps within the current support networks. This feedback was integrated into the mobile app called Caregivers’ Circle upon development. The features of this app include a public forum for community discussions, a marketplace to buy and sell items, care groups to hold private discussions with friends or other users of the app, and a friends feature to search and add new caregiving friends.

Conclusions

In general, the caregivers liked the Caregivers’ Circle app and were confident that this app could help them have a better quality of life. The Caregivers’ Circle app is unique in its integrated approach. The integration of many features that caregivers need on a daily basis into an easy app can save their time as well as help them navigate their life smoothly.
eHealth Literacy Instruments: Systematic Review of Measurement Properties (Preprint)
Authors: Lee Jiyeon , Lee Eun-Hyun , Chae Duckhee
Published: May 2021

BACKGROUND

The internet is now a major source of health information. With the growth of internet users, eHealth literacy has emerged as a new concept for digital health care. Therefore, health professionals need to consider the eHealth literacy of consumers when providing care utilizing digital health technologies.

OBJECTIVE

This study aimed to identify currently available eHealth literacy instruments and evaluate their measurement properties to provide robust evidence to researchers and clinicians who are selecting an eHealth literacy instrument.

METHODS

We conducted a systematic review and meta-analysis of self-reported eHealth literacy instruments by applying the updated COSMIN (COnsensus-based Standards for the selection of health Measurement INstruments) methodology.

RESULTS

This study included 7 instruments from 41 articles describing 57 psychometric studies, as identified in 4 databases (PubMed, CINAHL, Embase, and PsycInfo). No eHealth literacy instrument provided evidence for all measurement properties. The eHealth literacy scale (eHEALS) was originally developed with a single-factor structure under the definition of eHealth literacy before the rise of social media and the mobile web. That instrument was evaluated in 18 different languages and 26 countries, involving diverse populations. However, various other factor structures were exhibited: 7 types of two-factor structures, 3 types of three-factor structures, and 1 bifactor structure. The transactional eHealth literacy instrument (TeHLI) was developed to reflect the broader concept of eHealth literacy and was demonstrated to have a sufficient low-quality and very low-quality evidence for content validity (relevance, comprehensiveness, and comprehensibility) and sufficient high-quality evidence for structural validity and internal consistency; however, that instrument has rarely been evaluated.

CONCLUSIONS

The eHealth literacy scale was the most frequently investigated instrument. However, it is strongly recommended that the instrument's content be updated to reflect recent advancements in digital health technologies. In addition, the transactional eHealth literacy instrument needs improvements in content validity and further psychometric studies to increase the credibility of its synthesized evidence.
Incidencias monocéntrica y policéntrica del urbanismo residencial en la fragmentación de Tampico, México (1960-2015)
Authors: Garcés Carrillo Judith del Carmen , Bartorila Miguel Ángel
Published: May 2021

La expansión metropolitana de Tampico observa un panorama urbano complejo y difuso donde la presencia y proliferación de fragmentos urbanos residenciales, manifiestan una imagen difusa y de fractura espacial sobre la periferia. Utilizando la ecología del paisaje como instrumento de medición, se analiza el efecto que dichas urbanizaciones generan entre 1960 y 2015, mediante la obtención del índice de fragmentación que muestra dos lapsos diferenciados de crecimiento urbano, el primero como un crecimiento compacto de tipo monocéntrico hacia los años 1990 y el segundo un crecimiento con tendencia fragmentada hacia el año 2015 con características policéntricas.
MANİSA İLÇELERİNDE YÜKSEKÖĞRENİM GÖREN ÖĞRENCİLERİN KÜLTÜREL VE SANATSAL ETKİNLİKLERE KATILIMLARINA İLİŞKİN BİR İNCELEME
Authors: KÖROĞLU Nihat , KARAMAN Sibel , KÖROĞLU Gamze Nevra , BAKİ Harun
Published: May 2021

Üniversitelerin bulundukları illere bağlı ilçelerde eğitim-öğretim faaliyeti gösteren fakültelerinin, yüksekokullarının ve meslek yüksekokullarının ilçelere sosyal, kültürel ve ekonomik açıdan katkı sağladıkları bilinmektedir. Öğrencilerin bulundukları ilçeye olan katkıları bilinmekle birlikte ilçelerin öğrencilere bu anlamda sunmuş olduğu katkı çoğunlukla yetersiz kalmaktadır. Bu bağlamda araştırmanın konusu, Manisa ilçelerinde öğrenim gören öğrencilerin kültürel ve sanatsal etkinliklere olan ilgileri ve katılım durumlarının tespit edilmesidir. Araştırma konusundan hareketle 2019-2020 eğitim-öğretim yılında Manisa Celal Bayar Üniversitesi’nin ilçe yerleşkelerinde öğrenim görmekte olan fakülte, yüksekokul ve meslek yüksekokulu öğrencileri çalışma grubunu oluşturmaktadır. Çalışma grubunu oluşturan öğrencilerin kültürel ve sanatsal etkinliklere katılımlarını ölçmek için veri toplama araçlarından biri olan anket tekniği uygulanmış ve uygulanan anket sonucunda, kültürel ve sanatsal etkinliklere katılımın ilçelerdeki nüfus yoğunluğuyla doğru orantılı olarak değiştiği, sinemaya gitmenin bu etkinlikler içerisinde en yüksek, canlı performans etkinliklerine katılımın en düşük oranda olduğu sonuç bölümünde paylaşılmıştır.
"Sinceramente, sua": cartas anônimas em Rosario Ferré
Authors: Coser Stelamaris
Published: May 2021

Após breve análise do gênero epistolar e a especificidade da carta anônima, com exemplos da literatura brasileira, focalizam-se as cartas inseridas no conto ‘La bella durmiente”/‘Sleeping Beauty”, de Rosario Ferré (original 1976). Conjugando análise textual e contextualização sociocultural, este trabalho associa as cartas anônimas à condição feminina e à situação marginal de Porto Rico como estado/nação.
Gênero, identidade e poder: uma reflexão sobre Vasto mar de sargaços, de Jean Rhys
Authors: Carreira Shirley de Souza Gomes
Published: May 2021

Este trabalho propõe uma análise do romance Vasto mar de sargaços, de Jean Rhys, no intuito de demonstrar como a autora desconstrói o discurso eurocêntrico de Charlotte BrontÃ« em Jane Eyre, concedendo voz ao sujeito colonizado, além de permitir um ‘mergulho” na teia que o patriarcado teceu, aprisionando homens e mulheres em papéis sociais pré-determinados.
Memorias del silencio. Literaturas en el Caribe y en Centroamérica, de Graciela Salto
Authors: Perilli Carmen
Published: May 2021

Livro resenhado:SALTO, Graciela. Memorias del silencio. Literaturas en el Caribe y en Centroamérica. Edición, compilación y prólogo de Graciela Salto. Buenos Aires: Corregidor, 2010.---Resenha em espanhol.
Rotas horizontais: caminhos da crítica literária latino-americana do presente
Authors: Mata Ariadne Costa da
Published: May 2021

Nos últimos anos, a tendência à horizontalidade se tornou visível, particularmente, nos movimentos sociais, mas também além deles. Ela indica uma nova arquitetura das organizações humanas e pede mudanças no modo como o conhecimento é produzido e organizado. Mais que uma simples eliminação de fronteiras entre campos antes distinguíveis, a horizontalidade implica a descentralização e disseminação do poder.
Pesquisa quantitativa e qualitativa em Sociolinguística: dadaísmo metodológico?
Authors: Cardoso Caroline Rodrigues
Published: May 2021

A confluência entre pesquisas quantitativas e qualitativas na Sociolinguística é um dadaísmo metodológico? O cerne da discussão aqui não é a epistemologia, pois parto do pressuposto de que a Sociolinguística estuda a língua atrelada ao social. Busco demonstrar que o enfoque metodológico depende da pergunta de pesquisa, ou seja, do tema a respeito do qual se desenvolve uma tese.
Literatura infantil: entre a infância, a pedagogia e a arte
Authors: Simões Lucila Bonina Teixeira
Published: May 2021

O artigo tem por objetivo discutir dois conceitos fundamentais para a teoria e a crítica da literatura infantil: a concepção de criança sobre a qual se constroem as obras infantis e a função social atribuída à literatura infantil. O texto analisa como importantes teóricos da literatura infantil brasileiros trataram da questão e como as diferentes concepções de infância determinaram o percurso da literatura infantil no país.
ENTREVISTA COM MARIA HELENA DE MOURA NEVES
Authors: Sousa Gisele Cássia de
Published: May 2021

Panorama e perspectivas dos estudos sobre língua em uso no Brasil.
ANÁLISE VARIACIONISTA DA EPÊNTESE VOCÁLICA MEDIAL NA AQUISIÇÃO DE INGLÊS COMO L2
Authors: Lima Luana Anastácia Santos de , Lucena Rubens Marques de
Published: May 2021

O presente trabalho investiga a ocorrência da epêntese vocálica medial (object > ob[i]ject) na produção oral de aprendizes brasileiros de inglês como L2. A partir de uma metodologia sociolinguisticamente orientada, investigamos a produção de 18 aprendizes submetidos a leituras de frases e textos em língua inglesa. Os dados foram submetidos a uma análise estatística, utilizando o GoldVarb X.
A NATUREZA DA MUDANÇA NAS LÍNGUAS NATURAIS
Authors: Lima-Hernandes Maria Célia , Cunha Angélica Furtado da
Published: May 2021

Livro resenhado:MARTELOTTA, Mário Eduardo. Mudança linguística: uma abordagem baseada no uso. São Paulo: Cortez, 2011. 136 p.
TRADUÇÃO INTERSEMIÓTICA E LEGENDAGEM: ADAPTAÇÃO DE LINGUAGENS PARA COMPREENSÃO DE CULTURAS
Authors: Branco Sinara de Oliveira
Published: May 2021

Este artigo apresenta um estudo imagético sobre representação cultural, tendo como base dois filmes brasileiros – O Auto da Compadecida (2000) e Cidade de Deus (2002). Será analisado até que ponto legendas e imagens são suficientes para a transmissão de significado de representações culturais. Mesmo quando as legendas mostram algum tipo de limitação, as imagens demonstram, em pelo menos 93,75% dos casos, informações que transmitem as representações culturais dos dois ‘brasis” distintos que os filmes apresentam.
LATIM E CIÊNCIA: PERSPECTIVAS NA TRADUÇÃO DO LATIM CIENTÍFICO
Authors: Kaltner Leonardo Ferreira
Published: May 2021

Consiste o presente artigo em um estudo sobre as perspectivas interdisciplinares que se apresentam na tradução de textos científicos, tendo como eixo de debate os Estudos de Tradução, a Linguística Textual e a Língua Latina. Apresentamos a tradução de um excerto da Historia Naturalis Palmarum (História Natural das Palmeiras), escrita no século XIX, pelo botânico Carl Friedrich Philipp von Martius (1794 – 1868), um dos pioneiros na descrição da flora brasileira.