bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment for generalized anxiety disorder through physical exercise: a systematic review
Authors: Moura Denésio de Oliveira , Moreira Elisângela Claudia de Medeiros , Dias Claudio Alberto Gellis de Mattos , Fecury Amanda Alves , Dendasck Carla Viana , Souza Keulle Oliveira da , Pires Yomara Pinheiro , Seruffo Marcos César da Rocha , Bahia Mirleide Chaar , Oliveira Euzébio de
Published: January 2023

Introduction: Physical exercise improves various physical abilities, as well as it can promote improvement in the clinical condition of several diseases, including those related to the central nervous system. In this sense, the objective of this work was to produce a systematic review of the literature to investigate whether exercise is capable of promoting improvement in the clinical condition in human adults diagnosed with generalized anxiety disorder, whether there is a specific physical exercise, as well as whether the intensity of it is related to the improvement in the disease.

Methods: Randomized clinical trials published up to May 2019 were searched in online databases (PubMed, Scopus, Web of Science, Cochrane Library, LILACS, OpenGrey and Google Scholar) after developing a PICO statement focused on comparison between adults who received an intervention with the practice of regular, planned and supervised physical exercises, compared with sedentary participants and after verifying their effects in the context of generalized anxiety disorder. The search and data extraction were performed following the guidelines of the PRISMA manuscript writing guide. Quality assessment and risk of bias were analyzed following the Cochrane – RoB 2.0 protocol.

Results: A total of 4694 reference articles were retrieved/searched, while only six were considered eligible for the present review. Most articles showed a reduction in generalized anxiety disorder from an intervention with physical, aerobic and anaerobic exercises of moderate intensity. However, in the risk of bias analysis, all articles showed some concerns regarding the reported evidence.

Conclusion: Physical exercise is a potential tool for reducing generalized anxiety disorder, and moderate exercise intensity is directly related to an improvement in the clinical condition of the disease, regardless of the type: aerobic or anaerobic. However, it is important that further research seek to investigate the physiological and neuroendocrine mechanisms related to such improvement.

Keywords: Physical exercise, Anxiety, Systematic review.
Mechanisms of immune responses to infections by Arboviruses
Authors: Cruz Neto Manoel Samuel , Moreira Elisângela Claudia de Medeiros , Fecury Amanda Alves , Dendasck Carla Viana , Dias Cláudio Alberto Gellis de Mattos , Ramos João Batista Santiago , Souza Keulle Oliveira da , Bahia Mirleide Chaar , Pires Yomara Pinheiro , Oliveira Euzébio de
Published: January 2023

Arboviruses and arboviruses represent an ancient threat to a large part of humanity. This threat consists mainly in the ease that viruses and their vectors have to adapt, also in the fact that their RNA allows many mutations and genetic recombinations. There are still no effective vaccines for arboviruses such as Dengue, Chikungunya and Zika virus, therefore, it is extremely important for the scientific community to produce work on our body’s defenses against these arboviruses. The present research, which has a qualitative, descriptive and exploratory character, has as its main objective to investigate how immunological responses to arboviruses occur, with specific objectives to explore the various aspects related to the epidemiology of arboviruses and aspects related to the microbiology and cell biology of the processes immune responses of arbovirus hosts. The work consisted of a bibliographic review covering scientific works such as articles, monographs, dissertations and theses related to the investigated theme. After the aforementioned data collection, it was possible to describe how immune responses occur in their various forms, which are shown to be the main immunological mechanisms performed by our organism.
Las potencialidades de las artes en proyectos pedagógicos feministas con infancias. Una alterotopía en el espacio escolar
Authors: Becerril Fernández Juana Viridiana
Published: January 2023

El presente artículo presenta parte de los resultados obtenidos en mi investigación de Doctorado en Pedagogía realizada en la UNAM. Su objetivo fue indagar sobre las potencialidades de las artes en proyectos feministas con infancias, profundizar en sus fundamentos pedagógicos teóricos y metodológicos, así como ubicar sus complejidades y límites. Para ello, se realizó un proyecto de intervención pedagógica en la primaria Virgilio Uribe en Iztapalapa, una de las delegaciones con mayores índices de violencia de género. El corazón de esta intervención lo constituyeron dos laboratorios de experimentación artística, uno desde la dramatización y otro desde la lectura y escritura creativa. Ambos espacios se pensaron desde las coordenadas metodológicas de la Investigación Basada en las Artes (IBA) (Barone y Einser, 2006), las pedagogías feministas (Maceira, 2007) y las nuevas perspectivas de las infancias (Gaitán, 1990; Qvortrup, 1992; Medina, 2016). Estos laboratorios constituyeron escenarios pedagógicos significativos para los desaprendizajes de género (Camnitzer, 2017; Deleuze y Guattari, 2009). Estos espacios permitieron “habitar la diferencia” y desde ahí vivenciar otra forma de vincularse fuera de las expectativas de los estereotipos de género y finalmente constituyeron espacios para imaginar otros escenarios posibles, otros finales a las situaciones de violencia y desigualdad que las y los personajes de los cuentos les presentaron y que fueron un pretexto para espejear sus propias historias.
Hastanede Yatan Çocuklarda Malnütrisyon Riskini Tanımlamada Kullanılan Tarama Araçları: Gerçekler ve Çelişkiler
Authors: Serçe Hatice , Gökmen Özel Hülya
Published: January 2023

Malnütrisyon enerji, protein ve diğer besin ögelerinin yetersizliği veya fazlalığında gelişen bozulmuş nütrisyon durumudur. Hastane yatışı sırasında çocuk hastalarda nütrisyonel durum normal olsa dahi hastane yatışı sonrasında hastalık kaynaklı nütrisyonel durumun bozulması malnütrisyona yol açabilir. Hastanede yatan hastalarda malnütrisyon riskini tanımlamak ve beslenmenin sistematik yönetimi için hastane yatışından sonraki ilk 24 saat içinde her hastaya nütrisyonel tarama yapılması önerilir. Tarama araçları hastanede yatan çocuklarda nütrisyonel bozulmanın ve malnütrisyon gelişme riskinin farkındalığını arttırır. Mevcut tarama araçlarındaki birçok bileşen benzer olsa da vücut bileşenini değerlendirmede kullanılan yaklaşımlar ve puanlamada farklılıklar nedeniyle bütün tarama araçları arasındaki uyum orta düzeydedir. Hastanede yatan çocuklarda rutin kullanım için en uygun tarama aracının belirlenmesinde, ilgili tarama aracının klinik etkinliğinin onaylanmış olmasına ve pratikte uygulanabilirliğine dikkat edilmesi yararlı olabilir. Bu derlemede, hastanede yatan çocuklarda malnütrisyon riskini tanımlamada kullanılan tarama araçlarının etkinliğinin değerlendirilmesi amaçlanmıştır.
Надзвичайні ситуації і психологічне благополуччя: індикатори стану
Authors: Довгань Наталія
Published: January 2023

Актуальність. Для збереження психологічного благополуччя громадян та суспільних груп у надзвичайних ситуаціях необхідні комплексні дії фахівців сфери охорони здоров’я. Використання надійних індикаторів у діагностуванні психічного стану допомагає психологам, психотерапевтам, психіаторам в узгодженні плану допомоги особам, які пережили надзвичайну ситуацію.
Мета статті систематизувати і проіллюструвати індикатори психічного неблагополуччя постраждалих у надзвичайних ситуаціях згідно еталонних документів ВООЗ (посттравматичного стресового розладу, комплексного посттравматичного стресового розладу, гострої стресової реакції).
Результати. Представлено стислий огляд індекаторів стресових розладів згідно Міжнародної статистичної класифікації хвороб та проблем (ICD-11), пов'язаних зі здоров'ям й Діагностичного та статистичного посібника із психічних розладів (DSM-5). Зазначається, що прийняття рішення щодо оптимальних шляхів допомоги вибудовується на основі результатів детального аналізу патологічних процесів, які можуть розгортатися внаслідок надзвичайної ситуації. Для зручності використання матеріалів класифікаційних систем у діагностичній роботі із постраждалими у надзвичайних ситуаціях пропонуються бланки індикаторів психологічних і психічних проблем. У матеріалах бланків відображається змістовність підгрупи розладів, які пов'язуються зі стресом (Disorders specifically associated with stress) 06 блоку ICD-11, що узгоджені із критеріями розладів, які пов’язуються із травмою чи стресом у DSM-5: посттравматичного стресового розладу, комплексного посттравматичного стресового розладу, гострої стресової реакції.
Перспективи подальших досліджень. Проіллюструвати індикатори психічного неблагополуччя постраждалих у надзвичайних ситуаціях згідно груп розладів, що пов’язуються із дистресом, розладів настрою, розладів, що пов’язуються з тривогою або страхом.
Penerapan Pendidikan Karakter Anak Usia Dini Terhadap Generasi Alpha di Abad 21
Authors: Nimatuzahroh Nimatuzahroh , Khoirunnisa Himatul , Niyarci Niyarci
Published: January 2023

Semakin maju teknologi digital dapat menyebabkan memudarnya nilai-nilai karakter, sehingga perlunya fondasi pendidikan karakter pada generasi alpha khususnya anak usia dini, artikel ini bertujuan untuk mengidentifikasi pentingnya penerapan pendidikan karakter anak usia dini terhadap generasi alpha  di abad 21. Metode yang digunakan yaitu studi pustaka atau literature. Hasil penelitian di abad 21 anak usia dini harus memiliki 4C yaitu berpikir kritis dan menyelesaikan masalah, kreativitas, kemampuan berkomunikasi, dan kemampuan untuk bekerjasama. Pendidikan karakter melalui berbagai pendekatan seperti keteladanan, kebiasaan, nasihat dan pengawasan. Model pembelajaran pendidikan karakter pada anak usia dini merupakan proses pemberdayaan potensi pada anak proses humanisasi, dan proses pembudayaan, model-model pembelajaran pendidikan yaitu penanaman nilai, berbasis perkembangan penalaran moral, analisis nilai, project citizen.
Hubungan Pola Asuh Orang Tua Terhadap Kemandirian Anak Usia Dini 5-6 Tahun
Authors: Nur Fauziyyah Alina , Syafrudin Ulwan , Hariri Hasan
Published: January 2023

Penelitian ini dilatarbelakangi karena masih terdapat anak yang belum optimal dalam melakukan tugas perkembangan sesuai dengan usianya melalui kegiatan sehari-hari anak baik dilingkungan sekolah, maupun lingkungan rumah. Tujuan dari penelitian ini adalah untuk mengetahui hubungan dan tingkat hubungan dari pola asuh orang tua terhadap kemandirian anak usia dini pada kelompok B pada Taman Kanak-kanak di Rejo Basuki. Variabel dalam penelitian ini yaitu pola asuh orang tua yang menjadi variabel X dan kemandirian anak usia dini yang menjadi variabel Y. Penelitian ini merupakan penelitian kuantitatif, dengan metode penelitian yang digunakan adalah metode penelitian korelasional dengan teknik pengumpulan data melalui kuisioner. Sampel penelitian sejumlah 30 anak dengan kisaran usia 5-6 tahun dan 30 orang tua anak di Taman Kanak-kanak Rejo Basuki dengan menggunakan teknik sampling jenuh. Sampling jenuh adalah teknik penentuan sampel bila semua anggota populasi digunakan sebagai sampel. Hasil penelitian ini  dapat ditarik kesimpulan bahwa ada hubungan yang signifikan antara pola asuh orang tua terhadap kemandirian anak usia 5-6 tahun. Hal ini dilihat dari nilai Sig sebesar 0, 000 yang mana lebih kecil dari 0. 05. Hubungan yang didapat dalam penelitian ini menunjukan bahwa pola asuh erat hubungannya dalam pembentukan kemandirian anak. Pola asuh demokratis yang paling berpengaruh terhadap kemandirian
Implementasi Media TV Sekolah sebagai Inovasi dalam Pendidikan di RA Darussalam
Authors: Srihayati Tety , Watini Sri
Published: January 2023

Tujuan penelitian ini untuk menjelaskan peran sentral inovasi dalam pembelajaran guna menjaga efektivitas dan relevansi pendidikan, termasuk pendidikan anak usia dini, di Indonesia. Pendidikan adalah sebuah proses perubahan sikap dan prilaku individu atau kelompok sebagai upaya mendewasakan manusia melalui sebuah upaya pengajaran dan pelatihan. Kemunculan berbagai inovasi pembelajaran yang sejalan dengan perkembangan teknologi dapat ditelusuri sejak munculnya globalisasi dan internet. Globalisasi telah mengaburkan berbagai batasan yang ada. Internet memberikan akses seluas mungkin kepada pendidik dalam mencari materi dan bahan ajar sebagai upaya meningkatkan kualitas pendidikan. Kemunculan TV Sekolah yang sejalan dengan perkembangan tekonologi dan globalisasi membuktikan bahwa dua faktor ini dapat membantu proses pembelajaran, termasuk pendidikan anak usia dini, berkat berbagai inovasi yang dilahirkannya. TV Sekolah muncul sebagai respon terhadap berbagai masalah pendidikan kontemporer yang dapat membawa dampak positif terhadap hasil pembelajaran. Melalui implementasi TV Sekolah, lahir berbagai variasi dalam proses pembelajaran untuk membantu anak usia dini dalam menerima berbagai materi yang disampaikan. TV sekolah telah memberikan pengalaman, nuansa, dan tantangan baru di saat yang bersamaan bagi siswa dan guru.
Dampak Attachment Ibu-Anak Terhadap Kemandirian Anak Usia 5-6 Tahun
Authors: Khoerunnisa Eneng , Kusdiwelirawan Acep
Published: January 2023

Attachment merupakan ikatan emosional yang dibangun oleh orang tua (Ibu) atau pengasuh dengan anak. Penelitian ini bertujuan untuk mengetahui pola attachment ibu-anak dan juga untuk mengetahui dampak attachment ibu-anak terhadap kemandirian anak usia 5-6 tahun. Metode yang digunakan dalam penelitian adalah metode kualitatif deskriptif. Penelitian ini bertempat di TK Alfardiatussa'adah, sukabumi. Teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Dalam penelitian ini peneliti mengambil 3 responden anak usai 5-6 tahun di kelas B1. Hasil penelitian menunjukkan bahwa pola kelekatan ibu-anak ke 3 responden berbeda. dilihat dari kedekatan subjek A, subjek M dan subjek S dengan Ibunya, dimana subjek A memiliki kelekatan aman (Secure Attachment), subjek M memiliki kelekatan aman (Secure Attachment), dan subjek S memliliki kelekatan tidak aman (Insecure Attachment). Subjek A yang memiliki keletan aman berdampak positif terhadap kemandiriannya, subjek M memiliki keletakan aman berdampak positif terhadap kemandiriannya sedangkan subjek S memiliki kelekatan tidak aman berdampak negatif terhadap kemandirian.
Keterlibatan Orang Tua Dalam Bidang Pendidikan Terhadap Perilaku Sosial Emosional Anak Usia Dini
Authors: Gustiana Eva , Kristi Pramudika Sari Agatha
Published: January 2023

Hubungan Keterlibatan Orangtua Dalam Bidang Pendidikan Terhadap Perilaku Sosial Emosional Anak Usia Dini, keterlibatan orangtua dalam bidang pendidikan terhadap perilaku sosial anak usia dini sangatlah penting. Penelitian ini bertujuan untuk mengetahui keterlibatan orang tua dalam pendidikan terhadap perilaku sosial emosional di RA An Nuur Manggari, semester II tahun pelajaran 2020/2021. Adapun jumlah anak didik di RA An Nuur Manggari adalah 74 anak. Penelitian ini bersifat kolaboratif antara peneliti dan orangtua. Data dikumpulkan melalui observasi dan dokumentasi. Analisis data menggunakan deskriptif kuantitatif dengan jenis penelitian ex post facto. Hasil penelitian ini menunjukan bahwa keterlibatan orangtua di RA An Nuur Manggaritermasuk dalam kategori tinggi sebesar 78,38 % dan perilaku sosial emosional anak pada kategori tinggi sebesar 54 %. Artinya keterlibatan orangtua dalam pendidikan sangat berhubungan signifikan. Kesimpulan dari penelitian ini adalah ada hubungan keterlibatan orangtua dalam bidang pendidikan terhadap perilaku sosial emosional di RA An Nuur Manggari.
Pengaruh Media Pembelajaran Card Sort Terhadap Kemampuan Literasi Membaca Anak
Authors: Juniarti Yenti , Mindi Ketut , Utoyo Setiyo
Published: January 2023

Pengaruh Media Pembelajaran Card Sort Terhadap Kemampuan Literasi Membaca Anak Kelompok B di Tk Pembina Agropolitan Tujuan penelitian ini adalah untuk mengetahui adanya pengaruh media  pembelajaran card sort  terhadap kemampuan literasi  membaca anak kelompok B di Tk Pembina Agropolitan. Metode pada penelitian ini mengunakan kuantitatif eksperimen pre-experimental ( one-group pre test-post test disaign). Adapun hasil penelitian dengan jumlah sampel yaitu 16 anak menunjukan adanya perubahan yang signifikan dilihat dari data pretest dan posttest. Hal ini dapat dilihat dari data pretest dengan memperoleh nilai rata-rata 12,62 dan standar deviasi 1,1543. Sedangkan pada pada posttest memperoleh nilai rata-rata 36,62 dan standar deviasi 1,927 Hasil tersebut membuktikan bahwa terdapat pengaruh signifikan sebelum dan sesudah di berikan perlakuan. Berdasarkan output test statistics, di ketahui sig-n (2 tailed) bernilai 0,000. Oleh karna itu 0,000  0,05 maka hipotesis diterima. Dengan demikian, hipotesis penelitian menyatakan bahwa terdapat pengaruh media pembelajaran card sort terhadap kemampuan literasi membaca anak kelompok B di Tk Pembina Agropolita.
LEVEL OF PARENTAL EDUCATIONAL SUPPORT FOR STUDENT LEARNING
Authors: JALAL DEEN CAREEMDEEN
Published: January 2023

Parents are the first teachers of their children, and their performance in school and overall well-being is influenced by them. Playing a significant role in educating children, parents are individuals who influence student behaviour through direct or indirect action. Parental support for student learning has a significant effect on student wellbeing and academic achievement. This research was aimed at determining parental educational support for student learning, mainly taking into account gender differences as a factor among secondary school children in Sri Lanka. Sri Lanka faces notable gender disparities in academic performance, with girls outperforming boys at every level of the educational system (Tushani and Sarma. The study used a survey research design and a questionnaire instrument for data collection. A stratified random sampling technique was used to select 1350 secondary school students. To analyse the data, the research used descriptive analyses such as mean, standard deviation and MANOVA analysis. The findings of the study demonstrate that parental educational support for student learning is was at a high level (overall mean of 4.296, overall S.D. of 0.702) among secondary school choldren in Sri Lanka. MANOVA analysis shows significant differences in parental educational support based on gender as parental educational support for female student learning is significantly higher than male students. Both father and mother should maximise their educational support for boys’ education, such as providing necessary educational materials or resources, encouraging learning that can improve the educational wellbeing of children in Sri Lanka.
REFUGEE CRISES IN THE CONTEMPORARY WORLD: AN ISLAMIC PERSPECTIVE
Authors: UL ISLAM NASSER
Published: January 2023

The Issue of refugees is one of the fundamental political cum international humanitarian crisis in the contemporary world. This Contemporary crisis is by and large the result of political unrest, armed conflicts and violence within the Muslim World. Questions like how should these refugees be treated in the Muslim world? What is the status of refugees in Islam vis a viz Western world? What is the historical treatment given to refugees in Muslim civilization and should refugees be treated as citizens of the host countries? The main purpose of this paper shall be to find out answers to these questions while attempting to find a common ground between the two perspectives of how refugees shall be treated in the contemporary world.
SOKONGAN PENTADBIR DAN FAKTOR KEMUDAHAN MEMPENGARUHI PENGGUNAAN ICT DALAM PENGURUSAN PDPC [ADMINISTRATIVE SUPPORT AND FACILITY FACTORS AFFECTING THE USE OF ICT IN TEACHING AND LEARNING MANAGEMENT]
Authors: BALAKRISHNAN KALAIVANY
Published: January 2023

This study aims to examine the support of administrators and convenience factors in influencing the use of ICT in teaching and learning management. The design of this study is s qualitative method on six teachers randomly selected from six schools in Alor Gajah District. Qualitative data were collected through interviews on simple randomly selected respondents. These qualitative data were analysed thematically. The results of the study found that administrator support, and facilities influence the level of ICT use in teaching and learning management. Improvements need to be made on the existing facilities so that teachers can use them optimally. Administrator support is essential so that teachers can implicate ICT in their teaching and learning management. These findings contribute to the increased use of ICT in the management of teaching and learning by teachers successfully.
FASIES KIPAS BAWAH LAUT PADA BATUAN BERUMUR PEREM-TRIAS, DAERAH KEKNENO, CEKUNGAN TIMOR
Authors: Permana Asep Kurnia , Prastian A.H
Published: January 2023

Cekungan Timor termasuk kedalam kategori semi mature yang memiliki potensi hidrokarbon, namun kompleksitas kondisi geologi dan banyaknya konsep yang berbeda-beda merupakan salah satu penyebab stratigrafi di cekungan ini sulit dimengerti. Penelitian stratigrafi rinci untuk mengidentifikasi fasies dan sub fasies lingkungan pada batuan berumur Perem-Trias dilakukan di daerah Kekneno, Nenas, Cekungan Timor untuk memberikan pandangan baru mengenai stratigrafi, sedimentologi dan fasies lingkungan pengendapan pada batuan berumur Perem-Trias di cekungan ini. Hasil analisis litofasies menunjukkan bahwa batuan yang berumur Perem di daerah Kekneno diendapkan pada fasies lereng bagian bawah sampai atas (lower to upper slope facies), sedangkan batuan berumur Trias umumnya diendapkan sebagai fasies sistem kipas luar (outer fan system facies), fasies paparan luar samping lereng atas (outer shelf to upper slope facies), fasies sistem kipas tengah (middle fan system facies), dan fasies sistem kipas dalam (inner fan system facies). Endapan-endapan alur (channel) dan pematang (levee) pada batuan berumur Trias berpotensi menjadi target play hidrokarbon.Kata Kunci: fasies, kipas bawah laut, batuan Perem-Trias, Cekungan Timor
Geologi Daerah Tamilouw-Haya, Kecamatan Tehoru, Kabupaten Maluku Tengah, Provinsi Maluku
Authors: Samalehu Herfien , Idrus Arifudin , Imam Setiawan Nugroho
Published: January 2023

Tamilouw-Haya terletak di bagian selatan Pulau Seram, Provinsi Maluku yang berada pada elevasi 3 - 675 m di atas permukaan laut. Studi ini bertujuan untuk mengetahui kondisi geomorfologi, stratigrafi dan stuktur geologi di wilayah penyelidikan. Tahapan penyelidikan menggunakan kajian studi pustaka, kegiatan lapangan (fieldwork), analisis petrografi, serta interpretasi peta DEM (digital elevation model). Dari hasil kegiatan menunjukkan bahwa geomorfologi daerah ini terdiri atas 2 (dua) satuan morfologi, yaitu satuan perbukitan rendah berlereng sangat landai - curam dan satuan dataran rendah. Tatanan stratigrafi dibagi menjadi 5 (lima) satuan batuan yang terdiri atas satuan filit kuarsa-muskovit, satuan batusabak kuarsa-muskovit, satuan meta-batupasir kuarsa-muskovit, satuan batugamping koral dan endapan aluvial. Struktur geologi yang berkembang merupakan lipatan antiklin serta liniasi yang berarah utara baratlaut - selatan tenggara dan timurlaut - baratdaya yang membentuk sesar geser mengiri (sinistral) dan menganan (dekstral). Katakunci: Geomorfologi, liniasi, lipatan antklin, stratigrafi, struktur geologi.
Source Rock Characterization of the Eocene-Miocene, Central Deep, North East Java Basin
Authors: Iqbal Hidayat Fauzan , Yogi Ade , Sabra Eriko , Ramli Taufik , Firdaus Muhammad , Mersil Saleh Hanif , Ghia Arviallyn Gadis , Setyo Wibowo Andi
Published: January 2023

This study was conducted to obtain the characteristics of the source rock through organic geochemical analysis in Central Deep, NE Java Basin, in the field off the north coast of Madura. Three samples of Cassiopeia-1, Pollen-1, and Alpha-1 wells were analyzed using organic geochemical methods including Total Organic Carbon analysis, Maturity using vitrinite reflectance, Tmax, and Production Index data, and then analysis of the kerogen type, isoprenoid, sterane, and carbon isotope. Based on those data, an analysis was carried out to determine the origin of the material and the depositional environment. The rock samples in the three wells showed characteristics in TOC, maturity, kerogen type and source of organic material have a similarity. The source rock characteristics have a medium to a good category as source rock and tend to generate gas and a little oil from kerogen types II and III. This source rock is included in the category of immature to mature, deposited in delta until terrestrial depositional environment and contains sources terrestrial and marine organic material.Keywords: Madura, North East Java Basin, organic geochemical, source rock.
Pola Perubahan Iklimpurba pada Umur Pliosen dengan Proksi Foraminifera: Studi Kasus Formasi Sentolo, Yogyakarta
Authors: Novita Dian , Rizkika Wirawan Dwika , Rijani Sonia , Hermawan Undang
Published: January 2023

Studi distribusi foraminifera untuk menentukan pola perubahan iklimpurba pada umur Pliosen dilakukan pada Formasi Sentolo. Daerah survei terletak di sebelah barat kota Yogyakarta. Secara regional daerah ini merupakan bagian dari Pegunungan Kulon Progo. Pengukuran stratigrafi dilakukan dengan metode Tongkat Jacob dengan total ketebalan lapisan 38,9 meter. Bagian bawah daerah survei tersusun oleh perlapisan batupasir karbonatan-napal. Bagian tengah berkembang fasies perlapisan batugamping-batupasir karbonatan dan di ketebalan 25 meter berkembang perlapisan batugamping packstone-rudstone. Bagian atas pengukuran stratigrafi kembali berkembang fasies batupasir karbonatan dengan sisipan napal. Analisis lingkungan pengendapan dengan metode P/B ratio mendapatkan dinamika lingkungan pengendapan dari batial bawah hingga neritik luar. Analisis biozonasi mendapatkan zona Globigerina nepenthes dengan kisaran umur N19 (Pliosen Awal) dan zona Globorotalia pseudomiocenica dengan umur N20 (Pliosen Akhir). Dijumpai dua pola perubahan iklim di daerah survei, yaitu pola mendingin pada Pliosen Awal dan pola menghangat pada Pliosen Akhir. Hal tersebut memiliki pola yang sejalan dengan kurva eustasi global yang menunjukkan adanya penurunan muka air laut global pada Pliosen Awal dan kenaikan muka air laut secara gradual memasuki Pliosen Tengah. Katakunci: Foraminifera, Formasi Sentolo, iklim purba, Pliosen
Reduksi Efek Dimensionalitas 3D pada Data Magnetotelurik Menggunakan Analisis Koherensi, Tren Kurva, dan Skin Depth: Studi Kasus di Pulau Yapen Bagian Selatan dan Sekitarnya, Papua
Authors: Junursyah Gusti Muhammad Lucki , Parlindungan Edwin , Hidayat Hidayat , Harja Asep
Published: January 2023

Data magnetotelurik rentan terhadap noise akibat penggunaan sumber alami yang berasal dari aktivitas matahari dan petir dengan rentang frekuensi yang sangat lebar. Oleh sebab itu, diperlukan proses reduksi noise secara kuantitatif dan kualitatif, yaitu dengan cara analisis koherensi, proses tren kurva, dan skin depth, yang menghasilkan koherensi data mencapai rata-rata 91,5 %. Analisis skewness dilakukan untuk mengevaluasi tipe distorsi 1D, 2D, atau 3D, yang terjadi pada tensor impedansi. Kemunculan efek dimensionalitas 3D akibat adanya distorsi pada tensor impedansi pada 8 (delapan) lokasi pengukuran magnetotelurik di Pulau Yapen bagian selatan dan sekitarnya telah tereduksi secara keseluruhan oleh analisis koherensi, proses tren kurva, dan skin depth, sehingga hasil data tidak perlu dilakukan analisis rotasi terlebih dahulu sebelum dilakukan pemodelan inversi 1D-2D. Hasil penafsiran pada penampang tahanan jenis 2D memperlihatkan bahwa batuan dasar di daerah ini adalah Batuan Gunungapi Yapen yang ditindih secara tidak selaras oleh Batugamping Wurui.Katakunci: Koherensi, magnetotelurik, skewness, skin depth, tren kurva.
Perubahan Lingkungan Holosen Akhir Berdasarkan Rekaman Polen dari Delta Berau-Kalimantan Timur
Authors: Sri Sukapti Woro , Tri Dewi Kresna
Published: January 2023

Biodiversitas atau keragaman hayati merupakan aspek penting dalam pengembangan geopark selain keragaman geologi dan keragaman budaya. Keragaman hayati modern dapat diketahui berdaasarkan survei flora dan fauna. Meskipun secara natural keragaman saat ini berasal dari keragaman di masa lalu, namun perbedaan keragaman hayati keduanya dapat berbeda karena terjadinya perubahan lingkungan. Keanekaraman hayati masa lalu dapat diketahui berdasarkan fosil yang terawetkan di dalam sedimen. Dalam konteks tumbuhan di masa lalu, keanekaragamannya dapat diketahui berdasarkan fosil serbuk sari yang terawetkan di dalam sedimen. Hasil identifikasi polen dari sebuah inti bor sepanjang 100 cm di Delta Berau, Kalimantan Timur menunjukkan 80 jenis polen dan 13 jenis spora. Jenis polen yang hadir didominasi oleh jenis-jenis polen tumbuhan hutan dataran rendah. Proporsi polen dari jenis dan kelompok tumbuhan tertentu memberi informasi tentang kelimpahan tumbuhannya di dalam hutan baik hutan dataran rendah, hutan mangrove, hutan pegunungan dan tumbuhan padang rumput. Data keanekaragaman dan kelimpahan tumbuhan berdasarkan fosil polen dan spora dalam sedimen ini dapat digunakan untuk menyokong tersedianya informasi saintifik tentang keanekaragaman hayati pada kala Holosen di Kawasan warisan geologi Sangkulirang-Mangkalihat.Katakunci: Biodiversitas, dinamika hutan, hutan dataran rendah, hutan padang rumput, hutan pegunungan, mangrove, polen, spora.
Karakteristik Geokimia Organik dan Indeks Kegetasan Serpih Berumur Eosen-Oligosen di Sub Cekungan Jambi, Cekungan Sumatera Selatan
Authors: Zajuli, ST.,MT Moh. Heri Hermiyanto , Nurdiana Indra , Ramli Taufik
Published: January 2023

Daerah penyelidikan terletak di Sub Cekungan Jambi, Cekungan Sumatra Selatan. Secara administrasi termasuk Kabupaten Tebo dan Sarolangun. Studi ini difokuskan pada karakteristik geokimia organik dan indeks kegetasan (BI) dari serpih Formasi yang berumur Eosen-Oligosen. Metodologi yang digunakan adalah hasil analisis laboratorium TOC, XRD dan petrofisika dari data log dan seismik. Berdasarkan data tersebut maka serpih yang terdapat di daerah penyelidikan mempunyai kecenderungan berpotensi sebagai sumberdaya migas nonkonvensional dengan kategori bagus. Dari hasil perhitungan volume sweetspot serpih ini diketahui volume SS_01 adalah 1.17 x 1012 ft2 dengan luas area 8.9 x 108 ft2 dan volume SS_02 adalah 5.01 x 1011 ft2 dengan luas area 4.21 x 108 ft2 .Kata kunci : Geokimia Organik, TOC, Indeks Kegetasan, Cekungan Sumatra Selatan, Eosen-Oligosen.
Infundibular Widening of Angiographically Invisible Duplicate Anterior Choroidal Artery Mimicking Typical Anterior Choroidal Artery Aneurysm
Authors: Park Jaechan , Kim Jong-Soo
Published: January 2023

A diagnosis of an intracranial aneurysm depends on the angiographic configuration and should be cautiously differentiated from aneurysm mimics. In cases of duplicate anterior choroidal arteries (AChAs), infundibular widening of the distal minor AChA can be an aneurysm mimic. If the minor AChA with a smaller diameter is obscured angiographically due to poor contrast filling, an associated infundibular widening beside the proximal large AChA can misinterpreted as a typical AChA aneurysm in angiograms. The authors report on two such cases of duplicate AChAs with infundibular widening presenting like a typical AChA aneurysm in angiograms. Surgical exploration revealed a perforating artery emitting from the dome of the saccular lesion, confirming infundibular widening of a duplicate AChA. No reparative procedure was applied to the infundibular widening in a 48-year-old man, while two vascular outpouchings from the infundibular widening were clipped preserving the duplicate AChA in a 55-year-old woman.
Advanced T and Natural Killer Cell Therapy for Glioblastoma
Authors: Yoon Wan-Soo , Chung Dong-Sup
Published: January 2023

Although immunotherapy has been broadly successful in the treatment of hematologic malignancies and a subset of solid tumors, its clinical outcomes for glioblastoma are still inadequate. The results could be due to neuroanatomical structures such as the bloodbrain- barrier, antigenic heterogeneity, and the highly immunosuppressive microenvironment of glioblastomas. The antitumor efficacy of endogenously activated effector cells induced by peptide or dendritic cell vaccines in particular has been insufficient to control tumors. Effector cells, such as T cells and natural killer (NK) cells can be expanded rapidly ex vivo and transferred to patients. The identification of neoantigens derived from tumor-specific mutations is expanding the list of tumor-specific antigens for glioblastoma. Moreover, recent advances in gene-editing technologies enable the effector cells to not only have multiple biological functionalities, such as cytokine production, multiple antigen recognition, and increased cell trafficking, but also relieve the immunosuppressive nature of the glioblastoma microenvironment by blocking immune inhibitory molecules, which together improve their cytotoxicity, persistence, and safety. Allogeneic chimeric antigen receptor (CAR) T cells edited to reduce graft-versushost disease and allorejection, or induced pluripotent stem cell-derived NK cells expressing CARs that use NK-specific signaling domain can be a good candidate for off-the-shelf products of glioblastoma immunotherapy. We here discuss current progress and future directions for T cell and NK cell therapy in glioblastoma.
TÜRKİYE’DE EĞİTİM HARCAMALARI ve EKONOMİK BÜYÜME İLİŞKİSİ ÜZERİNE AMPİRİK BİR ANALİZ
Authors: KÖKSEL Bilge , TECİRLİ Sebile
Published: January 2023

1960’lı yıllar ile birlikte eğitimin ekonomik boyutları önem kazanmıştır. Beşerî sermaye kavramının en önemli bileşenlerinden birisi, eğitimdir. İçsel büyüme teorileri ile birlikte de beşerî sermayenin ekonomik büyüme üzerindeki etkisi ön plana çıkmıştır. İyi eğitilmiş ve nitelikli işgücü, beşerî sermayenin temelidir. Bir ülkenin büyümesi ve gelişmesi için sadece fiziki sermaye yeterli değildir. Fiziki sermayenin kullanılması ve üretim sürecine dahil olması ise nitelikli işgücü ile mümkündür. Nitelikli işgücü için de eğitim şarttır. Eğitim, bir ülkenin gelişmesine katkı sağlayan en önemli unsurlardan birisidir. Bundan dolayı, eğitime ayrılan pay önemlidir. Eğitim harcamaları, kamu harcamaları içerisinde önemli bir yer tutmaktadır.

Çalışmanın amacı, Türkiye’de eğitim harcamalarının ekonomik büyüme üzerindeki etkisinin 1980-2020 dönemi için ampirik olarak analiz edilmesidir. Analizde eğitim harcamaları (EDC) bağımsız değişken, ekonomik büyüme göstergesi kişi başı GSYİH bağımlı değişken olmaktadır. Analiz sonucunda elde edilen ampirik bulgular, eğitim harcamalarından ekonomik büyümeye doğru bir nedensellik ilişkisinin varlığını göstermektedir.
Frontal System Track Variation and Its Impact on Water Availability in Northern Pakistan Using Remote Sensing and Ground Data During Monsoon Season- 2019
Authors: Qureshi J. , Mahmood S.A. , Amin A. , Mahmood T.
Published: January 2023

Pakistan, which is positioned in the South Asian sub-continent, occupies a significant climatological location. It is included among the world's few countries which experience a comprehensive transformation from summer all the way to winter season. The variation in precipitation has direct and significant consequences on society. In this ongoing research, the latitudinal variation in the track of the frontal system and trends in Pakistan during the monsoon period have been examined. Meteorological data (monthly rainfall, maximum temperature, satellite images, upstream data for Tarbela, Mangla, Rasool, and Marala) has been taken to conduct the ongoing research. Consequently, the focus of the study is the frontal weather system that moves North of Pakistan and energizes the monsoon rainfall over the Indus Basin which makes it a source of flooding. The rainfall is the cause of flooding downstream of rivers in the plains of Punjab and Sindh. Varying trends in rainfall were observed across the selected stations in Pakistan. The ongoing research is conducted across Pakistan with Gilgit and Skardu being the cities in Northern Pakistan. Among all the water reservoirs, Tarbela exhibited an increased upstream flow due to the snow melt factor over glaciers in Gilgit and Skardu because of an increase in maximum temperature.
OSMANLI DEVLETİ’NDE SIĞIR VEBASI: ASKERİ BAYTARLARIN GÖREVLENDİRİLMESİ MESELESİ
Authors: TAN Seda
Published: January 2023

Sığır vebasının ilk çağlardan itibaren var olduğu geniş ölçüde kabul gören bir görüştür. Yine bu görüşe göre hastalık Çin’in doğusunda ortaya çıkmış ve Hun akınlarıyla birlikte Avrupa içlerine kadar taşınmıştır. Avrupa’ya nüfuz eden sığır vebası 19. yüzyıla kadar olan süreçte büyük çoğu yine Asya kökenli muhtelif salgında milyonlarca hayvanın ölümüne neden olmuştur. Tecrübe edilen salgınlardan devlet ekonomileri ile insan sağlığı önemli ölçüde etkilendiğinden hastalıkla mücadelenin ve salgınların önüne geçmenin yolları aranmıştır. Bu çerçevede bir taraftan veteriner hekimliği eğitimi başlatılıp mesleki bir teşkilatlanmanın teminine girişilirken bir yandan da hastalıklarla mücadelenin etkin biçimde yürütülmesini sağlayacak mevzuat hazırlanmaya ve nihayetinde devletlerin özgün deneyimlerinin diğerleriyle paylaşılmasını ve ortak bir hafızaya aktarımını sağlayacak uluslararası düzeydeki platformların oluşturulmasına çalışılmıştır. Avrupa devletleri söz konusu girişimleri sayesinde 1871-1872’de etkili olan son büyük epidemiyi takiben sığır vebasını önemli ölçüde kontrol altına alıp büyük salgınların önüne geçebilmişlerdir. Bu tarihten sonra hastalık daha çok doğuda görülür olmuştur. Sığır vebası Osmanlı topraklarında da büyük kırımlar yaratmıştır. Özellikle 19. yüzyılda yaşanan atakların olumsuz etkileri 20. yüzyıl ortalarına dek sürmüştür. Hastalığın kendisi de ancak Cumhuriyet devrine eradike edilebilmiştir. Devletin bu fenomenle başa çıkamamasında uzman kadro yetersizliği temel etkenlerdendir. Ele alınan çalışma da buna odaklanmaktadır. Dönemin arşiv kayıtlarından hareketle Osmanlı merkez otoritesinin özellikle 1885 sonrası süreçte hastalıkla mücadele edecek kadrolarını oluşturmadaki performansın portresi ortaya konulmaya çalışılmıştır. Çalışmanın ana kaynağını ele alınan dönem için birinci el kaynak kabul edilen ve Cumhurbaşkanlığı Devlet Arşivleri Başkanlığı’nın Osmanlı Arşiv kısmında Dahiliye(Mektubi Kalemi), Yıldız(Mütenevvi Maruzat); İrade(Askeri, Dahiliye, Hususi, Orman ve Maadin, Taltifat), Bab-ı Ali Evrak Odası ve Meclis-i Vükela Mazbataları fonlarında yer alan arşiv belgeleri oluşturmaktadır.
Environmental changes surrounding congenital heart disease
Authors: Choi Eun-Young
Published: January 2023

As the outcomes of patients with congenital heart disease (CHD) improve, the number of patients is accumulating and the proportion of adult CHD patients is gradually increasing. Accordingly, the proportion of typical adult diseases such as coronary arterial disease, diabetes, dyslipidemia, and hypertension among patients with CHD is increasing, as is the medical burden due to residual cardiac problems, heart failure, and arrhythmias. Due to increasing genetic knowledge, efforts are being made to provide active medical support through risk stratification. Surgical techniques and prostheses are also developing, the instruments used for transcatheter intervention are diversifying, and the range of therapeutic options is expanding. In addition, owing to the development of electronic devices, heart rhythm and blood pressure monitoring instruments have been miniaturized and diversified. In this process, a vast amount of information is collected; therefore, the current systematic review examined their clinical usefulness. A team approach consisting of experts from various fields is essential for the treatment of patients with CHD and advanced heart failure.
Taze Kesilmiş Pırasada Askorbik Asit Uygulamasının Soğukta Depolama Boyunca Kalite Değişimine Etkisi
Authors: GÜLAL Bekir , KOYUNCU Mehmet Ali
Published: January 2023

Çalışmada askorbik asit (AA) uygulamasının taze kesilmiş ‘Lincoln’ pırasa çeşidinin soğukta depolama boyunca kalitesi üzerine etkileri incelenmiştir. Optimum dönemde derimi yapılan pırasalar hızlı bir şekilde laboratuvara nakledilmiştir. Pırasalar zorlanmış hava ile (2 °C) 6 saat süreyle ön soğutma işlemine tabi tutulduktan sonra uygulamalar (kontrol, %1 ve %2 AA) için üç gruba ayrılmıştır. Ön soğutma işleminden sonra pırasalar serin ve steril koşullar altında 5-6 °C sıcaklıktaki çeşme suyuna birkaç kez daldırarak bahçe kaynaklı toz ve kalıntılar uzaklaştırılmıştır. Taze kesim işleminden sonra %1 ve %2 AA uygulanmış pırasa örnekleriyle kontrol grubu köpük kâselere yerleştirilerek üzeri streç filmle (16 µ) kaplanmıştır. Ambalajlanmış pırasalar 0±1 °C ve %90±5 oransal nemde 30 gün boyunca depolanmıştır. Depolama boyunca altı gün aralıklarla pırasalarda ağırlık kaybı (%), yalancı gövde sertliği (N), suda çözünebilir kuru madde (%), titre edilebilir asitlik (g 100 ml-1), solunum hızı (ml CO2/kg‐1 h‐1), yalancı gövde rengi ve duyusal özellikler belirlenmiştir. AA uygulamaları kontrole kıyasla taze kesilmiş pırasalarda ağırlık kayıplarını azaltmıştır. Depolama boyunca %2’lik doz daha etkili olmak üzere, AA uygulamaları yalancı gövde sertliğini kontrole göre daha iyi korumuştur. Soğukta depolama boyunca AA uygulamaları taze kesilmiş pırasaların TEA miktarını korumuş ve solunum hızını net bir şekilde baskılamıştır. AA uygulamaları kontrol örneklerine kıyasla depolama süresince pırasaların görsel kalitelerini daha iyi korumuştur. Sonuç olarak, AA uygulanmayan kontrol grubundaki pırasalar 0±1 °C ve % 90±5 oransal nemde 24 gün depolanabilirken, her iki AA (%1ve %2) uygulaması bu süreyi 30 güne kadar uzatmıştır. Ancak farklı doz ve uygulama şekilleri kullanılarak bu konuda daha detaylı çalışmalara ihtiyaç vardır.
A Comparison of Acrylamide Contents of Some Nuts Produced Organically and Conventionally
Authors: YILMAZ Baha Aydın , AYDIN ÜNSAL Işın , TAŞAN Murat
Published: January 2023

Acrylamide is a carcinogenic and neurotoxic compound defined as a heat treatment process contaminant. Due to its health concern, acrylamide formation needed to be minimized. The objective of this study is to examine how much acrylamide is contained in dried almonds (Prunus dulcis), hazelnuts (Corylus avellana), pistachios (Pistacia vera), peanuts (Arachishypogaea), sunflower seeds (Helianthus annuus) as well as pumpkin seeds (Cucurbita pepo) that have been cultivated via organically-certified and conventional processes. Frequently and regularly-consumed nuts - comprising 180 samples that have been cultivated via organically-certified and conventional processes - were studied with UHPLC-MS/MS approach in Turkey. Substantial disparities were statistically found (P
Study on Controlling Residual Stress in Thick Copper Film for Heat Sink Using Graphene
Authors: Bae Jeongwoon
Published: January 2023

Nowadays, high-density electronic devices and component mounting have gained popularity. Because of the heat generated from these devices, efficiency of the electronic parts is significantly lowered and life time of these devices is considerably shortened. Therefore, it is very important to efficiently dissipate the heat generated from the device to extend product. In this study, a copper thick film was deposited using a sputtering technique using plasma. In addition, graphene, a two-dimensional nanomaterial, was inserted in the form of a sandwich structure between the deposited copper (Cu) layers of various thicknesses. Through this, a study was conducted to control the residual stress of thick copper foil deposited by sputtering. In this study, the residual stress was measured according to the location where graphene was inserted, the treatment method, and the transfer area. As a result, the highest residual stress reduction effect was observed when the transfer area of graphene was about 70%. Reduction of residual stress was observed by inserting graphene into the deposited copper thick film of various thicknesses. In addition, by increasing the number of layers of graphene inserted, changes in residual stress were observed.
Un relato anti-geopolítico de la identidad angolana: La traumática historia del colonialismo en Angola a través de Teoría General del Olvido
Authors: De Pablo Javier , Di Minico Elisabetta
Published: January 2023

La historia poscolonial de Angola está marcada por feroces guerras, la de la independencia contra Portugal, el país colonizador, y la guerra civil que la siguió. En tal contexto, se sitúa un sistema de conflicto constante entre yo y otro, centro y periferia, exterior e interior. A través de la perspectiva de la geopolítica popular y del análisis sociopolítico e histórico, se realiza un examen de la novela de 2012 Teoría general del olvido. El artículo pretende analizar el imaginario anti-geopolítico propuesto por el autor y reflexionar sobre la violencia entre alteridad e identidad inherente a la Angola colonial y poscolonial, aclarando cómo la memoria, la violencia y la pacificación se entrecruzan en la historia del país.
Anti-oxidant, Anti-diabetic and Anti-inflammatory Effect of Muntingia calabura (L.) Fruit Extract
Authors: Sowmya S.  , Jayaprakash A.
Published: January 2023

The anti-oxidant, anti-diabetic and anti-inflammatory properties of Muntingia calabura fruit extracts were studied by in vitro models. Various solvent extraction of Muntingia calabura were primarily analyzed by phytochemical test, and the aqueous methanolic extract was found more potent in all the aspects of analysis. Phytochemical analysis showed the presence of phenol, flavonoids, and tannins. The fruit extract exhibited good antioxidant capacity and revealed an anti-inflammatory effect when compared to standard and the extract demonstrated anti-diabetic efficacy by enhancing glucose transport across the cell membrane in yeast cells without deleterious effects by in vitro model.
ANTIFUNGAL AND WOUND HEALING ACTIVITIES OF CHITOSAN NANOPARTICLES FROM GREEN MUSSEL SHELL (Perna viridis) AND JERNANG (Daemonorops draco) ETHANOL EXTRACT DRESSING PATCH
Authors: Nuraeni Novi , Yuvie Arkhi , Pratama Putu , Herianti Danisha , Kusumaningtyas Valentina , Jasmansyah Jasmansyah
Published: January 2023

The development of chitosan nanoparticles and jernang (Daemonorops draco) as wound medicine materials have received a lot of attention from researchers. In this research the two materials will be combined. The antifungal of the materials determined based on inhibition test of Candida albicans and Malassezia furfur. The wound healing activities determined based on the in vivo wound healing test on Wistar rat (Rattus novergicus). The materials applicated on wound dressing patch. Chitosan was sinthesized from green mussels shell waste (Perna viridis L). The result showed that the yield of chitosan was 64.67% and degree of deacetylation (DD) was 69.53%. Meanwhile, chitosan nanoparticles can be prepared based on ball mill process. The result showed that average of the particles size was 437.6 nm (nanoparticles size is 1-1000 nm). Jernang was obtained by maseration process using ethanol organic solvents technical. The yield was 22.41% and showed positively of alkaloid, saponin, flavonoid and triterpenoid test. F3 has highest activies on antifungal and wound healing test results.