Emergência de Staphylococcus aureus resistentes aos antimicrobianos: um desafio contínuo
Authors: Oliveira Caio Ferreira de , Morey Alexandre Tadachi , Biasi-Garbin Renata Perugini , Perugini Marcia Regina Eches , Yamauchi Lucy Megumi , Yamada-Ogatta Sueli Fumie 
Published: November 2017

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Os seguintes descritores foram utilizados: methicillin-resistant </span><em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri-Italic;">Staphylococcus aureus </span></em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">(MRSA), MRSA infection, vancomycin-intermediate </span><em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri-Italic;">S. aureus </span></em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">(VISA), heterogeneous-VISA (hVISA), staphylococcal </span><em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri-Italic;">cassete </span></em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">chromosome </span><em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri-Italic;">mec </span></em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">(SCC</span><em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri-Italic;">mec</span></em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">). A seleção dos artigos foi baseada em dois critérios: 1) publicação entre os anos 2000 e 2014 (até a data de submissão); 2) artigos cujos autores contribuíram com descobertas relevantes sobre os temas, independente do ano de publicação. </span><strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri-Bold;">Resultados: </span></strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">As consultas realizadas nos bancos de dados resultaram em 268 artigos, dos quais 59 foram utilizados para escrita dessa revisão. </span><strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri-Bold;">Conclusão: </span></strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">As comunidades, médica e científica, são constantemente desafiadas com a emergência de bactérias resistentes aos antimicrobianos. MRSA continua sendo um grande problema de saúde pública no mundo todo. Resistência aos glicopeptídeos (vancomicina e teicoplanina), uma das últimas escolhas para o tratamento intravenoso de infecções causadas por cepas de MRSA também tem sido descrita. A partir deste novo cenário, observou-se o surgimento de VRSA (</span><em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri-Italic;">vancomycin-resistant S. aureus</span></em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">), VISA (</span><em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri-Italic;">vancomycin-intermediate S. aureus</span></em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">) e hVISA (</span><em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri-Italic;">heterogeneous</span></em><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">-VISA). Esses dados indicam a necessidade urgente de adoção de métodos mais sensíveis e rigorosos para detecção dessas cepas no laboratório de microbiologia clínica. 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