bluuebunny/crossref_metadata_2025 huggingface dataset:
Resection of Pulmonary Metastasis from Parathyroid Carcinoma
Authors: Hundley Jonathan C. , Albertson David A. , Bradley Robert F. , Levine Edward A.
Published: November 2022

The management of metastasis from parathyroid carcinoma (PC) is an unusual challenge. Systemic therapy has minimal effect on the course of the disease and its associated hypercalcemia. Resection of isolated pulmonary metastases is an attractive option in the setting of recurrent hypercalcemia. We report a case of a patient who underwent resection of multiple functional PC pulmonary metastases almost 20 years after the original neck resection. The patient originally presented in 1982 with what was thought to be hyperparathyroidism secondary to a parathyroid adenoma. Surgical exploration revealed the presence of a well differentiated PC. The patient was transiently normocalcemic, but underwent surgical exploration in 1993 and 1996 for recurrent PC in the neck. The patient again improved, but presented in 2001 with diffuse arthralgia, fatigue, malaise, weight loss, and decreased appetite. She was found to have a serum calcium of 12.7 mg/dL and an intact parathyroid hormone of 1542 pmol/L. Computed tomography identified the presence of two right-sided and two left-sided pulmonary masses. Sternotomy with bilateral pulmonary metastectomy was performed. Functional PC metastasis was confirmed on pathological examination. One year following metastectomy the patient is hypocalcemic, requiring oral calcium and vitamin D supplementation. Functional pulmonary metastasis from PC is a rare cause of hypercalcemia. Complete resection of isolated pulmonary metastases can provide effective palliation with long-term survival.
Incisional Herniorrhaphy with Intraperitoneal Composite Mesh: A Report of 95 Cases
Authors: Cobb William S. , Harris James B. , Lokey Jonathan S. , Mcgill Eric S. , Klove Karin L.
Published: November 2022

Incisional herniorrhaphy remains a formidable challenge to the general surgeon. Recurrence rates after primary repair are reported between 31–54 per cent while tension-free repairs with prosthetic mesh have lowered this rate to 10 per cent. Repairs with composite mesh (polypropylene/ePTFE) have been gaining in popularity due to the ease of mesh placement in the intraperitoneal location. This paper reviews our experience with composite repairs at a teaching community hospital. A retrospective chart review was performed which evaluated all patients undergoing abdominal incisional hernia repairs over a 4½-year period. The data were analyzed for mortality, recurrence, infection, subsequent bowel obstruction, and fistula formation. Two hundred twenty-one incisional herniorrhaphies were identified in the resident database of which 95 were repaired with Com[posix mesh (Bard Surgical, Cranston, RI) in the intraperitoneal position. There were two (2%) recurrences and eight (8%) infections. Fistulization to the small bowel from exposed polypropylene occurred in one patient. There were no bowel obstructions. One postoperative death occurred secondary to pulmonary embolus. Mesh removal was required in all infected cases, and there was a high incidence (63%) of methicillin-resistant Staphylococcus aureus (MRSA). Our findings parallel the low recurrence rate following prosthetic repair. We have reported a higher than expected infection rate particularly with MRSA. Although repairs with Composix mesh are highly successful in regard to recurrence, the high infection rate and resulting morbidity needs to be further evaluated.
Laparoscopy in the Evaluation of Penetrating Thoracoabdominal Trauma
Authors: Mcquay Nathaniel , Britt L.D.
Published: November 2022

The evaluation of penetrating thoracoabdominal trauma for the presence of a diaphragmatic injury presents a diagnostic challenge to the trauma surgeon. The use of diagnostic laparoscopy (DL) in this setting was reviewed at a level-one trauma institution. Eighty patients (71 males, 9 females) with penetrating injuries to the thoracoabdominal region underwent DL to rule out injury to the diaphragm. Fifty-eight patients (72.5%) had a negative study and were spared a celiotomy. In the remaining 22 patients (27.5%), injury to the diaphragm was identified. This subset of patients underwent a mandatory celiotomy to rule out an associated intra-abdominal injury. Seventeen out of 22 (77.2%) patients had a positive exploration requiring surgical intervention, representing an associated intra-abdominal injury rate of 21.2 per cent. Intra-abdominal injuries requiring repair included small bowel, colon, spleen, liver, and stomach, in descending order. There were no missed injuries or deaths. One patient with a left diaphragmatic injury secondary to a stab wound developed a subdiaphragmatic abscess. Respiratory insufficiency secondary to atelectasis was the most common complication. Diagnostic laparoscopy is an essential and safe modality for the evaluation of diaphragmatic injuries in penetrating thoracoabdominal trauma.
Reliability of Physical Examination as a Predictor of Vascular Injury after Penetrating Neck Trauma
Authors: Azuaje Rafael E. , Jacobson Lewis E. , Glover Jennifer , Gomez Gerardo A. , Rodman George H. , Broadie Thomas A. , Simons Clark J. , Bjerke H. Scott
Published: November 2022

The policy of routine angiography (ANG) for all penetrating neck wounds results in a high rate of negative studies. The medical records of all patients who presented to Wishard Memorial Hospital and Methodist Hospital of Indiana with penetrating injuries to the neck from January 1992 to April 2001 were reviewed. All patients who were hemodynamically stable underwent four-vessel ANG to evaluate for vascular injury irrespective of findings on physical examination (PE). A total of 216 patients sustained penetrating neck injuries. Patients were divided according to positive or negative PE findings and the results of ANG. Of the 63 patients with a positive PE, 40 (68%) also had a positive ANG finding. Of the 89 patients with negative PE, only 3 had a positive ANG and none of these injuries required operative repair. PE therefore had a 93 per cent sensitivity (SEN) and a 97 per cent negative predictive value (NPV) for predicting the results of ANG. The SEN and NPV of PE for detecting vascular injuries requiring operative repair were both 100 per cent. In this series, no patient with a negative PE had a vascular injury that required operative repair, irrespective of zone of injury. Routine ANG may therefore be unnecessary for patients with penetrating neck injuries and a negative PE.
Appendiceal Abscess: Immediate Operation or Percutaneous Drainage?
Authors: Brown Carlos V.R. , Abrishami Michael , Muller Matthew , Velmahos George C.
Published: November 2022

Conflicting evidence exists regarding the optimal treatment for abscess complicating acute appendicitis. The objective of this study is to compare immediate appendectomy (IMM APP) versus expectant management (EXP MAN) including percutaneous drainage with or without interval appendectomy to treat periappendiceal abscess. One hundred four patients with acute appendicitis complicated by periappendiceal abscess were identified. We compared 36 patients who underwent IMM APP with 68 patients who underwent EXP MAN. Outcome measures included morbidity and length of hospital stay. The groups were similar with regard to age (30.6 ± 12.3 vs. 34.8 ± 13.5 years), gender (61% vs. 62% males), admission WBC count (17.5 ± 5.1 x 103 vs. 17.0 ± 4.8 x 103 cells/dL), and admission temperature (37.9 ± 1.2 vs. 37.8 ± 0.9°F). IMM APP patients had a higher rate of complications than EXP MAN patients at initial hospitalization (58% vs. 15%, P < 0.001) and for all hospitalizations (67% vs. 24%, P < 0.001). The IMM APP group also had a longer initial (14.8 ± 16.1 vs. 9.0 ± 4.8 days, P = 0.01) and overall hospital stay (15.3 ± 16.2 vs. 10.7 ± 5.4 days, P = 0.04). We conclude that percutaneous drainage and interval appendectomy is preferable to immediate appendectomy for treatment of appendiceal abscess because it leads to a lower complication rate and a shorter hospital stay.
Does Reoperation Predispose to Postoperative Wound Infection in Women Undergoing Operation for Breast Cancer?
Authors: Tran Cam-Ly , Langer Samantha , Broderick-Villa Gregory , DiFronzo L. Andrew
Published: November 2022

Reoperations for breast cancer predispose to a higher risk of postoperative wound infections than primary procedures. We accomplished a retrospective chart review of 320 women who underwent multiple breast cancer procedures between 10/97 and 8/02. The mean number of procedures was 2.4 (range, 2–5). The overall incidence of wound infection was 6.1 per cent. Wound infections developed, on average, 12 days after surgery (range, 2–30). There was a statistically significant difference in the incidence of wound infection comparing the initial procedure versus the subsequent operation (1.6% vs. 9.4%, P < 0.001). This was also seen with reoperation after an operative biopsy compared to operation after a core biopsy (11.1% vs. 9.7%, P < 0.01). The incidence was increased to 22.0 per cent when the initial operation involved lymph node dissection (sentinel lymph node biopsy or complete axillary lymph node dissection). Wire localization did not increase the incidence of postoperative wound infections, and prophylactic antibiotics were associated with a decreased incidence of wound infection in the reoperative setting. The incidence of wound infection is increased with reoperation after operative biopsy compared to operation after core biopsy and is further increased when the initial biopsy involved lymph node dissection.
Lymphatic Tumor Burden Negatively Impacts the Ability to Detect the Sentinel Lymph Node in Breast Cancer
Authors: Vargas Hernan I. , Vargas M. Perla , Venegas Rose , Gonzalez Katherine D. , Burla Melissa , Mishkin Fred , Khalkhali Iraj
Published: November 2022

Sentinel lymph node (SLN) biopsy is the preferred method of nodal breast cancer staging. Techniques of SLN biopsy rely on transport of interstitial molecules through mammary lymphatics. Lymphatic flow may be disrupted by tumor emboli. Increased lymphatic tumor burden may be responsible for failure to identify the sentinel lymph node in patients with breast cancer. A prospective database of 110 patients who had SLN biopsy between January 2001 and December 2002 was analyzed. The number of metastatic axillary lymph nodes was used as a measure of lymphatic tumor burden. SLN was found in 94 per cent of cases. It was not found in seven patients; five of them had extensive axillary metastases (71%) compared to 23 per cent when SLN was found ( P = 0.001). The average number of metastatic lymph nodes was larger when SLN was not found compared to when SLN was found (12.8 vs. 3.9, respectively, P = 0.002). Increasing numbers of metastatic nodes correlated with decreasing success in SLN biopsy ( P = 0.075). The incidence of axillary metastases is higher in patients in whom the sentinel node is not found. High lymphatic tumor burden may have a causative role in SLN biopsy technical failure. Axillary dissection should be performed if SLN is not found, regardless of the tumor size or histology.
Appendicitis, 2002: Relationship between Payors and Outcome
Authors: Schweitzer Jeremy , Fairman Nathan , Schreyer Kristin , Waxman Kenneth
Published: November 2022

As the status of health-care insurance changes in the United States, studies have indicated that uninsured patients are less likely to receive timely and quality health care. Previous studies of appendicitis have shown that insurance status may effect the stage of presentation and outcome. However, these studies were based on databases lacking information regarding stage of presentation, timeliness of diagnosis and treatment, and character of hospitalization (length of stay, duration of antibiotic therapy, hospital costs). We accomplished a case control study, retrospective analysis of 975 patients treated for acute appendicitis between January 1996 and December 1999. Times to operation, number of preoperative outpatient visits, number of studies, severity of presentation, length of antibiotics and hospital stay, and hospital costs were analyzed [analysis of variance (ANOVA) techniques, P < 0.05 significant]. We sought answers to the following: (1) Did insurance status affect the timeliness of diagnosis and treatment? (2) Did insurance status affect the stage of presentation? (3) Did insurance status affect hospitalization, as measured by length of stay, duration of antibiotic therapy, and hospital costs? (4) Did age affect outcome independent of insurance status? There were no correlations between insurance status and timeliness of diagnosis or severity of presentation. Length of stay and hospital costs were also not different between insurance categories. Pediatric patients (<12 years old) and the elderly (>65 years old) presented with more advanced appendicitis, independent of insurance category. In contrast to previously published data, the treatment of acute appendicitis is not affected by insurance coverage in the sample community. Age and timeliness of presentation were the only factors correlating to outcomes.
Sequential Compression Devices as Prophylaxis for Venous Thromboembolism in High-Risk Colorectal Surgery Patients: Reconsidering American Society of Colorectal Surgeons Parameters
Authors: Ramirez Jesus I. , Vassiliu Pantelis , Gonzalez-Ruiz Claudia , Vukasin Petar , Ortega Adrian , Kaiser Andreas M. , Beart Robert W.
Published: November 2022

The American Society of Colorectal Surgeons (ASCRS) recently endorsed low-molecular-weight heparin and low-dose heparin as primary prophylaxis for venous thromboembolism (VTE) in highest-risk patients. Our study evaluates the feasibility of sequential compression device (SCD) use for VTE prophylaxis in these patients. Computerized databases of discharge diagnoses from three hospitals were reviewed. All patients with colorectal cancer or inflammatory bowel disease during a 7-year period were identified. Those who underwent major abdominal surgery and received VTE prophylaxis exclusively with SCDs were selected for the study. Patients diagnosed with postoperative VTE were identified through review of the three databases and of patient records for 90 days after surgery. One thousand two hundred eighty-one patients classified as highest-risk under the published ASCRS parameters underwent major abdominal surgery and received SCDs perioperatively. The incidence of clinically detectable postoperative VTE was 0.78 per cent. There were trends toward lower incidence among patients with malignancy (0.53%) compared with inflammatory bowel disease (1.48%, P = 0.09), and those with abdominal compared to pelvic procedures (0.62% vs. 1.04%, P = 0.41). Prophylaxis for perioperative VTE solely with SCD is a viable option for patients classified as highest-risk under ASCRS parameters.
Colorectal Malignancies in HIV-Positive Patients
Authors: Yegüez José F. , Martinez Sergio A. , Sands Dana R. , Sands Laurence R. , Hellinger Michael D.
Published: November 2022

Due to the development of more effective medications, those infected with HIV are living longer. Consequently, more tumors and infections have been added to the AIDS-defining criteria in the last decade. Our aim was to review the occurrence and clinical course of colorectal (CR) malignancies in HIV infected/AIDS patients from a single institution. A retrospective review of HIV/AIDS patients with colorectal malignant tumors was undertaken. We included adult patients, with ELISA and Western blot test positive for HIV, and primary malignant tumors located in the colon or rectum. Malignant neoplasms of the anus were excluded for the purposes of this study. Twelve patients (9 males and 3 females), mean age 41 years, were identified with the following neoplasm: 6 adenocarcinomas (ACA), 5 non-Hodgkin lymphomas (NHL), and 1 small-cell carcinoma. Intravenous drug abuse was the main risk factor for HIV. No patient had identified risk factors for colorectal neoplasm. Five out of six patients with ACA had metastatic disease at the time of diagnosis. One patient with stage II ACA developed early liver metastases after colonic resection. Seven out of 12 patients underwent surgery. Six (85.7%) of these sustained postoperative complications, primarily wound infection. The overall survival in our series was dismal, averaging 20 months. For NHL average survival was 29 months, and 12 months for CR-ACA. This is the largest series of cases of colorectal cancer in the HIV/AIDS patient population published in the English language and the largest number of colorectal ACA reported in this unique population. Early in our experience, tumors frequently found in immunoincompetent patients were detected (NHL). More recently, we have only treated patients with colorectal ACA; none of them had no risk factors for colorectal cancer (family history, IBD, FAP, HNPCC). These patients developed tumors at earlier ages and were diagnosed at an advanced stage. Therefore, these tumors may be associated with the grade of immunosuppression induced during the course of the HIV infection and with a tumorigenic effect of the HIV on the colonic epithelium. Consequently, a high index of suspicion when evaluating chronic abdominal complaints in such patients is warranted. The use of the new antiretroviral therapy regimens should be further evaluated to know its impact in the survival.
An Argument against Routine Sentinel Node Mapping for DCIS
Authors: Farkas E.A. , Stolier A.J. , Teng S.C. , Bolton J.S. , Fuhrman G.M.
Published: November 2022

Indications for sentinel lymph node mapping (SLNM) for patients with ductal carcinoma in situ (DCIS) of the breast are controversial. We reviewed our institutional experience with SLNM for DCIS to determine the node positive rate and clarify indications for nodal staging in patients with DCIS. Since 1998 we have used SLNM to stage breast cancer patients using both blue dye and radiocolloid. In DCIS patients, SLNM has been reserved for patients considered at high risk for harboring coexistent invasive carcinoma or treated by mastectomy. All sentinel nodes were evaluated with serial sectioning, hematoxylin and eosin staining, and immunohistochemical evaluation for cytokeratins. We identified 44 patients with 46 cases of DCIS (two patients with bilateral disease). SLNM identified at least one sentinel node in all cases. In all cases, the sentinel node(s) were negative for axillary metastasis. We calculated the binomial probability of observing 0 of 46 cases as negative when the expected incidence according to published reports in the surgical literature was 13 per cent and found a P value of <0.01. Based on this case-series observation, we conclude SLNM should not be routinely performed for patients with DCIS. We now use SLNM only for DCIS patients treated by mastectomy.
Does Setting Specific Goals and Providing Feedback during Training Result in Better Acquisition of Laparoscopic Skills?
Authors: Gonzalez Rodrigo , Bowers Steven P. , Smith C. Daniel , Ramshaw Bruce J.
Published: November 2022

The aim of this study was to evaluate whether setting specific goals and providing feedback stimulates trainees to improve their laparoscopic skills. Two groups of eight fourth-year medical students practiced on a MIST-VR trainer, a black box laparoscopic suturing trainer, and computer-based training modules for 30 minutes, twice a week for 3 weeks. A precourse assessment of laparoscopic and open suturing skills and performance of MIST-VR tasks was obtained. Students in group A were given specific goals to achieve and were provided feedback. Group B was given no specific goals or feedback. At the end of the course, seven different tasks and skills were evaluated and subjectively scored during a laparoscopic cholecystectomy in an animal laboratory. A higher number of students in group A completed 10 or more repetitions in the MIST-VR than in group B. The groups showed no difference in final MIST-VR or overall scores in the animal laboratory. The only different scores between groups were for the use of the nondominant hand (NDH). The initial scores in the acquired cut task (ACT) in the MIST-VR correlated well with the performance in the animal laboratory. Setting goals and providing feedback tended to motivate students to practice more compared with the self-directed group. There was no difference in final MIST-VR scores or the performance in the animal laboratory, except for the NDH. The best predictor of performance was initial ACT score.
Mucosal Regeneration of a Duodenal Defect Using Small Intestine Submucosa
Authors: De Ugarte Daniel A. , Choi Edmund , Weitzbuch Hal , Wulur Isabella , Caulkins Carrie , Wu Ben , Fonkalsrud Eric W. , Atkinson James B. , Dunn James C.Y.
Published: November 2022

Intestinal tissue engineering has the potential of developing new treatment strategies for patients with a deficit in intestinal surface area. The purpose of this study was to investigate the capacity of small intestine submucosa (SIS) to regenerate intestinal epithelia in a rodent model for a duodenal defect. A duodenotomy was created in 20 Sprague-Dawley rats and was repaired with a circular patch of SIS. The repaired sites were retrieved 1, 2, 4, and 12 weeks after implantation. The size of the residual mucosal defect was measured. The retrieved tissues were fixed in formalin and processed by standard histologic techniques. The animals tolerated the procedure well. The mean size of the mucosal defects significantly decreased with time. Complete epithelializa-tion of the defects was noted within 4 weeks in three of five samples. Histologically, the defects were lined with crypts and villi, but the muscularis layer did not regenerate. In the rodent model, SIS can be used as a patch to repair a duodenotomy. Mucosal regeneration was observed in the area of the defect. Further studies will determine whether SIS may be used to preserve or increase mucosal surface area in patients whose bowel length is compromised.
Granular Cell Tumor of the Breast
Authors: Montagnese Miguel D. , Roshong-Denk Stacie , Zaher Aiman , Mohamed Iman , Staren Edgar D.
Published: November 2022

Granular cell tumors (GCT) are uncommon, usually benign, neoplasms that are thought to derive from Schwann cells of the peripheral nerves. They can originate anywhere in the body but are most frequently found in the head and neck, particularly in the oral cavity. When they are located in the breast, as may occur in 5–8 per cent of cases, the clinical and pathologic appearance is similar to that of a malignant tumor. Immunohistochemical analysis, including reactivity for periodic acid–Schiff, CD68, and S100 and negative reactivity for cytokeratin, is required for definitive diagnosis. Awareness of this tumor's unique characteristics might aid in differentiating it from the more common malignant tumors of the breast.
Role of Sentinel Lymph Node Biopsy in Patients with Thick (>4 mm) Primary Melanoma
Authors: Jacobs Ira A. , Chang C.K. , Salti George I.
Published: November 2022

Lymphatic mapping and sentinel lymphadenectomy have become a routine part of the treatment algorithm for primary melanoma. Their role in the management of thick (>4 mm) lesions is evolving. Our purpose was to evaluate the influence of single lymph node (SLN) histology on survival of patients with thick melanomas. A computerized patient database was accessed to obtain records on patients with thick melanomas. Survival curves were constructed with the Kaplan-Meier method, and a Cox regression analysis was used to establish statistical significance. Between 1997 and 2002, 266 SLN biopsy procedures were performed, using both radioisotope and blue dye, in 259 patients with malignant melanoma. Forty-five patients (17%) had thick melanomas. Twenty patients (44%) had at least one positive sentinel lymph node. The mean disease-free survival (DFS) of SLN–positive patients was 44 months compared with 53 months in SLN–negative patients ( P = 0.0221). Increasing Breslow thickness was associated with a decrease in DFS, whereas no other histologic parameters such as Clark level, mitotic rate, or ulceration had an influence on DFS. Our data indicate that the status of the SLN node is predictive of disease-free survival in patients with thick melanomas. SLN biopsy is thus justified in patients with thick melanoma.
Splenic Infarction Associated with Anti-Car diolipin Antibody: A Report of Two Cases
Authors: Mcvay Carie L. , Zhang Yibin , Ko Albert , Memsic Leslie , Hamburg Solomon I. , Morgenstern Leon , Silberman Allan W.
Published: November 2022

There are few cases of splenic infarction associated with antiphospholipid antibody reported in the literature. We present two cases of splenic infarction associated with anticardiolipin antibody, one complicated by the development of a splenic pseudocyst. Clinical diagnostic features of splenic infarction are described. In addition, a review of the literature on thrombotic manifestations of antiphospholipid syndrome is presented.
Indicated Cholangiography in Patients Operated on by Routine versus Selective Cholangiographers
Authors: Kohn Annemarie , Creech Steve , Shayani Vafa
Published: November 2022

Intraoperative cholangiography (IOC) remains a subject of much debate among laparoscopic surgeons. When IOC is indicated, the surgeon's preference for routine cholangiography (RC) or selective cholangiography (SC) may have an impact on the outcome of IOC and cholecystectomy. Hereafter, we present our experience with cholangiography in patients with clear indications for IOC when operated on by surgeons favoring SC versus RC. Between January 1, 1999, and December 1, 2000, 389 patients underwent laparoscopic cholecystectomy at Loyola University Medical Center. One hundred fifty-one patients had indication for IOC (jaundice, pancreatitis, increased liver function tests (LFTs), abnormal anatomy, ductal dilatation, or ductal stones identified on preoperative ultrasound), and they constitute the sample for this study. The results of IOC and subsequent outcome of cholecystectomy were reviewed using the electronic medical database. Thirty-nine patients were operated on by 2 surgeons favoring RC and 112 by 12 favoring SC. Patient demographics were similar in both groups. Only 30 (27%) of the SC group had attempted IOC with 28 successful IOCs (25% of all patients). In contrast, 38 (97%) of the RC group had successful IOC, which was significantly higher than the SC group ( P < 0.0001 by χ2test). Adverse events included conversions to open, postoperative endoscopic retrograde cholangiopancreatography, bile leak, repeat operative intervention, pancreatitis, elevated LFTs, intraabdominal and wound infection, prolonged emesis, and persistent abdominal pain. Two (5%) adverse events occurred in the RC group, which was significantly less than the 33 (30%) adverse events in the SC group ( P = 0.002 by χ2test). Conversions to open were significantly less in the RC group, with no conversions in the RC group and 20 (18%) in the SC group ( P = 0.005). There were no mortalities in this series. In a univariate analysis, age and gender did not correlate with increased risk of complications. In conclusion, surgeons who perform SC are less likely to attempt IOC even when IOC is indicated. More conversions to open and more adverse events occurred following cholecystectomy by those favoring SC. Our study further supports routine cholangiography during laparoscopic cholecystectomy.
Influence of Demographics on Colorectal Cancer
Authors: Mostafa Gamal , Matthews Brent D. , Norton H. James , Kercher Kent W. , Sing Ronald F. , Heniford B. Todd
Published: November 2022

The purpose of this study was to examine the influence of race, gender, and age on colorectal cancer cases in our tumor registry between January 1987 and December 2000 and to determine the implications of these factors on screening strategies. Tumors were defined as early (Stage I/II) or late (Stage HI/IV) and proximal or distal (relationship to splenic flexure). Effect of age was examined by stratifying patients into three groups (<50 years, 50–70 years, >70 years). Two time periods (1/87–12/96 and 1/97–12/00) were compared. Significance ( P < 0.05) was determined by univariate and logistic regression analysis. Between January 1987 and December 2000, 1355 patients (M:F, 699:656; mean, 65.9 years) were entered into the tumor registry [998 whites, 357 African Americans (AA)]. The AA population had a significantly higher proportion of females ( P = 0.0001) and patients <50 years ( P = 0.01). The incidence of carcinoma in situ (CIS) was significantly higher in AA ( P = 0.01). African Americans were more likely to present with late disease ( P = 0.05), proximal cancers ( P = 0.05), and well-differentiated tumors ( P = 0.04). In the entire cohort, proximal lesions were significantly larger ( P = 0.002), poorly differentiated ( P = 0.002), and occurred more often in females ( P = 0.03), patients >70 years ( P = 0.04), and patients with family history of colon cancer compared to distal lesions. Proximal migration of tumors occurred in the latter part (1997–2000 compared to 1987–1996) of the study ( P = 0.002). Patients <50 years had a higher incidence of late stage ( P = 0.03) and poorly differentiated tumors ( P = 0.009). The probability for a proximal tumor in an AA female >70 years was 61.9 per cent and in a white male >50 years was 35.1 per cent. Significant differences exist in the stage and location of tumors according to patient's age, race, and gender. These factors should be considered in implementing public screening strategies. Specifically, African-American patients were more likely to present with late-stage tumors, and more aggressive patient education and screening programs should be implemented. For all groups, a proximal migration of colorectal tumors was identified. This factor should eliminate use of sigmoidoscopy as a screening tool. Complete colonoscopy, instead, should be the procedure of choice to identify colonic neoplasia.
The Ultrasound Screen for Penetrating Truncal Trauma
Authors: Bokhari Faran , Nagy Kimberly , Roberts Roxxane , Brakenridge Scott , Smith Robert , Joseph Kimberly , An Gary , Barrett John
Published: November 2022

A prospective blinded pilot study was performed at an urban level 1 trauma center to evaluate the efficacy of ultrasound in ruling out penetrating visceral truncal injury. For 8 months, 49 nonconsecutive patients who presented with truncal gunshot and stab wounds were evaluated by a 10-MHz ultrasound tranducer probe. The deepest muscle bundle and the fascia enveloping it was examined by ultrasound. These images were compared to the equivalent contralateral unaffected side of the patient. All the patients then underwent standard testing to evaluate for potential intracavitary injury. Forty-nine patients with a mean age of 28 years (SD, 8.8) were evaluated by ultrasound. A total of 58 injuries were evaluated of which 37 were stab wounds and 21 were gunshot wounds. Thoracoabdominal and back and flank injuries were the most commonly evaluated injuries. There were 20 true positives, 20 false positives, and 18 true negatives, each with approximately twice as many stab as gunshot wounds. There were no false negatives. The sensitivity and negative predictive value of ultrasound in determining clinically significant truncal visceral injury in penetrating truncal trauma is 100 per cent. The specificity and positive predictive value are both approximately 50 per cent. Ultrasonic examination of the injured abdominal wall layers in truncal penetrating trauma is an excellent screening tool. Simple comparative assessment with the unaffected contralateral side allows a highly sensitive method of decreasing the number of potentially morbid, time consuming, and expensive tests that are currently employed to rule out visceral injury.
Acute Vagotomy Does Not Augment the Systemic Inflammatory Response in Patients with Peptic Ulcer Disease
Authors: Heider T. Ryan , Koruda Mark J. , Farrell Timothy M. , Behrns Kevin E.
Published: November 2022

Recent accumulating evidence suggests that the vagus nerve modulates the response to peripheral immunologic stimuli and that intact vagal mediation decreases the systemic inflammatory response. We hypothesized that patients who had vagotomy for complicated peptic ulcer disease would be at increased risk of an enhanced systemic inflammatory response compared to patients that did not have a vagotomy as part of their operative treatment. Ninety-six patients were identified from 1985 to 2000 and their medical records were reviewed. Patients were assigned to three groups based on the performance of a truncal vagotomy: truncal vagotomy (TV; N = 62 patients), nontruncal vagotomy (NTV; N = 34 patients), or a subgroup of the TV group, acute truncal vagotomy (ATV; N = 40 patients). Operative indications in the NTV and ATV groups were perforation (94% vs 47%) and bleeding (6% vs 53%). Systemic or organ-specific complications did not differ between groups (NTV vs ATV), and the sepsis (24% vs 23%) and mortality rates (29% vs 20%) were similar. The ICU and hospital length of stay did not differ substantially among the groups. This clinical study demonstrated that acute truncal vagotomy does not increase the risk of the systemic inflammatory response in surgical patients with complicated peptic ulcer disease.
The First Lung Transplant
Authors: Dalton Martin L.
Published: November 2022

On the occasion of the 40th anniversary of the first successful human lung transplant performed by Hardy et al., it seems prudent to review the preliminary research, the operative procedure, and the outcome of this significant operation. I have also attempted to establish the primacy of this operation for James Daniel Hardy.
Rapamycin Inhibits Release of Tumor Necrosis Factor-α from Human Vascular Smooth Muscle Cells
Authors: Adkins Jonathan R. , Castresana Manuel R. , Wang Zhongbiao , Newman Walter H.
Published: November 2022

Neointimal proliferation with plaque formation is the principal cause of coronary artery disease. In the neointima, inflammatory cytokines like tumor necrosis factor-α (TNF-α) are expressed by vascular smooth muscle cells (VSMCs). These cytokines stimulate proliferation and migration of VSMCs, events that are crucial to neointima formation. Stents, liberating rapamycin, have been shown to reduce neointima formation in human coronary arteries. The purpose of this study was to determine if rapamycin could inhibit the production of TNF-α by VSMCs. With institutional review board approval, VSMCs were cultured from saphenous vein segments obtained from five patients. Cells were identified as VSMC by immunostaining for smooth muscle α-actin. Cells were exposed to bacterial lipopolysaccharide (LPS), LPS plus rapamycin, or LPS plus isoproterenol for 24 hours. Cells with no treatment served as controls. The culture medium was then removed and analyzed for TNF-α. Additionally, the effect of treatment on viability was determined by assay of mitochondrial activity. TNF-α released into the culture medium is expressed as pg TNF-α/mg cell protein. Statistical analysis was by ANOVA. In control cells, TNF-α was undetectable in the culture medium. The addition of LPS (10 μg/mL) increased TNF-α release to 4312 ± 705 pg/mg at 24 hours. The addition of 1 ng/mL rapamycin with LPS reduced TNF-α production 50 per cent ( P < 0.01 vs LPS alone). A similar reduction of TNF-α release was seen with 1 μM isoproterenol. LPS, rapamycin, or isoproterenol did not affect cell viability. These data show that rapamycin effectively inhibits the release of TNF-α from VSMCs stimulated with inflammatory mediators like LPS. Rapamycin is as effective as agents that raise intracellular cyclic AMP (e.g., isoproterenol). Therefore, a potential mechanism for the effectiveness of rapamycin-releasing stents is reduction of inflammatory cytokine expression by VSMCs.
Sentinel Lymph Node Mapping and Biopsy for Ductal Carcinoma in situ and Other Controversial Indications
Authors: Fuhrman George M.
Published: November 2022

This review discusses the currently available literature regarding three controversial indications for sentinel node mapping for breast cancer patients. For women with ductal carcinoma in situ (DCIS), the use of sentinel lymph node mapping (SLNM) should be limited to women having a mastectomy. For patients with multifocal breast carcinoma, SLNM is accurate when a retroareolar injection technique is employed in the procedure. When treatment plans for node-negative patients call for neoadjuvant chemotherapy, accurate sentinel node mapping can be performed prior to the administration of chemotherapy. The resolution of these and other controversies should result in the expansion of the number of patients evaluated with SLNM in the future.
Technical Advances in Sentinel Lymph Node Biopsy for Breast Cancer
Authors: Tuttle Todd M.
Published: November 2022

Technical advances in the past several years have simplified and improved sentinel lymph node (SLN) biopsy for breast cancer. The use of alternative injection sites (skin or subareolar) yields high SLN identification rates and may shorten the learning curve associated with standard peritumoral injection. The dual-agent (radiocolloid plus blue dye) technique is now recommended to decrease false-negative rates, especially when surgeons are just learning how to perform SLN biopsy. Methylene blue may be an acceptable substitute for isosulfan blue dye and is associated with fewer hypersensitivity reactions. Hand-held gamma probes are now smaller and more maneuverable, with better shielding for directional detection of gamma rays. Routine preoperative lymphoscintigraphy can be avoided, thus facilitating operating room scheduling. Surgeons can use minimally invasive techniques to identify and remove internal mammary SLNs.
Pediatric Blunt Trauma Resulting in Major Arterial Injuries
Authors: Milas Zvonimir L. , Dodson Thomas F. , Ricketts Richard R.
Published: November 2022

Ten children, aged 4 to 14 years, sustaining blunt arterial trauma from motor vehicle collisions (6), bicycle accidents (2), and falls (2) were identified over a 10-year period. The arteries injured included the common iliac (3), abdominal aorta (2), carotid (2), brachial (2), and the subclavian, renal, and femoral artery (1 each). One patient had three arterial injuries. Six patients had associated injuries including a pelvic and lumbar spine fracture, Horner's syndrome, liver laceration, skull fracture, open humerus fracture, small bowel serosal tear, and a brachial plexus injury. Definitive diagnosis was made using arteriography (6), computed tomography (CT) scan (2), and physical examination (2). The types of arterial injuries found included incomplete transection, complete transection with pseudo-aneurysm formation, traumatic arteriovenous (AV) fistulas, complete occlusion, and dissection. Repair was accomplished by hypogastric artery interposition or bypass grafting, synthetic grafting with polytetrafluoroethylene (PTFE), reverse saphenous vein grafting, or primary repair, depending on the circumstances. An AV fistula between the carotid artery and cavernous sinus was embolized. All grafts remained patent with exception of the aorto-renal bypass graft at follow-up ranging from 1 month to 3 years. The principles for repairing vascular injuries in children are slightly different than those in adults. Every effort should be made to use autogenous tissue such as the hypogastric artery or saphenous vein for repair if possible. If not, PTFE grafts can be used, although the long-term patency of these grafts in growing children is not known.
Common Bile Duct Papillary Adenoma Causing Obstructive Jaundice: Case Report and Review of the Literature
Authors: Fletcher Nicholas D. , Wise Paul E. , Sharp Kenneth W.
Published: November 2022

Common bile duct (CBD) adenomas are rare tumors that often present in a fashion similar to their malignant counterparts. We report a case of a papillary CBD adenoma causing obstructive jaundice. We also present a review of the CBD adenomas found in the English literature through a Medline search (1970–2003). A 74-year-old female presented with a 10-day history of pruritus, progressive painless jaundice, acholic stools, bilirubinuria, and 10-lb weight loss. Abdominal exam showed no masses. Abdominal ultrasound (U/S) showed cholelithiasis without choledocholithiasis. Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic U/S revealed a shelf-like stricture, 1.5 cm long and 0.9 cm in diameter, located in the distal CBD. At the time of biliary stent placement, fine-needle aspiration showed benign ductal epithelial cells in sheets and clusters. Abdominal CT scan showed a low attenuation 15 x 17 mm lesion in the head of the pancreas that abutted the superior mesenteric vein (SMV) but no metastatic lesions. We performed a standard pancreaticoduodenectomy (Whipple procedure). Final pathology showed a papillary adenoma without evidence of dysplasia in the distal common bile duct proximal to the ampulla of Vater. The incidence of these tumors and their potential for malignant degeneration is unknown. Pancreaticoduodenectomy is an effective means of treatment and cure for CBD adenoma.
Reducing Medication Errors in a Surgical Residency Training Program
Authors: Larson Kenneth A. , Wiggins Ernest F. , Goldfarb Michael A.
Published: November 2022

Medication errors contribute to in-hospital morbidity and mortality. Teaching hospitals and the surgical residency training programs they support should take proactive steps to reduce error frequency. In order to accomplish meaningful error reduction, we must first define the scope and nature of the problem. Pharmacists at the Monmouth Medical Center prospectively recorded medication prescribing errors made by surgical residents during 2 years. These data were reviewed to determine the types of medication errors made most frequently by surgical house officers. Seventy-five medication-prescribing errors were made by surgical house staff in the years 2001 and 2002. Thirty-three of these errors involved orders for antibiotic therapy. Errors that could not be directly attributed to knowledge deficits were responsible for 36 of the 75 errors (48%), whereas specific knowledge deficits were responsible for 39 of the 75 errors (52%). Twenty-eight of the 36 errors not directly attributable to knowledge deficits (78%) were made at the postgraduate year one level, whereas only 15 of the 39 knowledge deficit errors (38%) were made at the postgraduate year one level. Though targeted education to address specific knowledge deficits may substantially reduce the occurrence of “knowledge deficit” medication errors within surgical residency training programs, more costly measures such as the implementation of physician computerized order entry will likely be needed to reduce maximally the frequency of medication ordering errors. Many prescribing errors cannot be attributed to specific knowledge deficits.
The Hottest Sentinel Lymph Node is Not Always the Positive Node
Authors: Camp E.R. , Cendan J.C. , Feezor R. , Lind D.S. , Wilkinson E. , Copeland E.M.
Published: November 2022

The technique of identifying the sentinel lymph node (SLN) varies from each individual institution. Generally, the highest isotope count in a lymph node is considered the SLN, whereas other radioactive nodes might also be removed. The purpose of our study was to determine if the hottest node was always the tumor-containing node. Two hundred forty-seven breast cancer patients underwent SLN biopsy from April 1998 to April 2002. Lymphatic mapping involved a radiocolloid injection and lymphoscintigraphy followed by intraoperative assessment with a hand-held gamma probe. All SLN(s) with radioactive counts 10 per cent or more of the ex vivo counts of the most radioactive SLN were removed. The SLN were sliced at 2-mm intervals with 4–μm step-sections (92–μm spacing) and evaluated by microscopy and immunohistochemistry. One hundred twenty (49%) of the 247 patients had 2 or more nodes resected. Of these 120 patients, 33 (28%) had a tumor-bearing node. In 25 (74%) cases, the tumor-bearing node was the most radioactive; however, in 8 (26%) cases, the positive node was a lesser reactive node. Although the most radioactive node in a draining basin is considered the SLN, this is often not the metastatic node. Therefore, all nodes with significant radioactive counts must be removed to ensure accurate staging.
Advanced Age is not a Prohibitive Factor in Laparoscopic Nephrectomy for Renal Pathology
Authors: Cobb William S. , Heniford B. Todd , Matthews Brent D. , Carbonell Alfredo M. , Kercher Kent W.
Published: November 2022

Since the first procedure by Clayman and colleagues in 1990, laparoscopic nephrectomy has been performed at multiple institutions worldwide and is an accepted approach for benign and malignant renal pathology. We retrospectively compared the outcomes of laparoscopic nephrectomy for renal pathology in patients older than and less than 65 years of age. Data were collected for all patients undergoing elective nephrectomy (simple, radical, and nephroureterectomy) for renal pathology between November 2000 and June 2003. A total of 94 laparoscopic nephrectomies (62 hand-assisted, 32 totally laparoscopic) for renal disease were performed. Indications for surgery included renal cell carcinoma (63), transitional cell carcinoma (7), hypertension (9), chronic pyelonephritis (6), nonfunctioning kidney (4), complex cyst (3), and polycystic kidney disease (2). There were 33 elderly patients (≥65 years) and 61 adult patients (<65 years). The elderly group had a mean operative time (238 min vs 234.3 min; P = 0.89) and blood loss (88.5 mL vs 149.8 mL; P = 0.68) similar to the adult group. Likewise, the incidence of perioperative complications was no different between the two groups (intra-op: 3.0% vs 0%; P = 0.35 / post-op: 21.2% vs 16.4%; P = 0.56). The length of hospitalization was longer in the elderly population (5.7 days versus 5.0 days; P = 0.01) compared to the younger adult group. Laparoscopic nephrectomy is well tolerated in the elderly population. For all surgical indications, the use of a minimally invasive approach confers operative times, blood loss, and morbidity that are comparable to those of younger patients. Yet, length of stay remains longer for elderly patients undergoing nephrectomy.