bluuebunny/crossref_metadata_2025 huggingface dataset:
Storm surges in the water level variation in the New Port (gulf of Ob)
Authors: Piskun A. A. , Voinov G. N.
Published: March 2020

The processing of 6-hourly intervals level measurements at the New Port polar station was previously difficult due to poor data quality and the lack of methodology for assessing them and bringing observations into uniform rows. Therefore, since the second half of the 20th century, no research of wind-induced water has been carried out. In 2015, for the first time, the authors formed a base of residual levels (observations minus forecasting) for 1977–2012 on 6-hourly intervals observations of water level at the New Port station using the method of tide calibration. In the present work, a period of observations with relatively reliable data for 1977–1991 was selected for the research of the storm surges in the water level fluctuations. Surges are considered in comparison with the 5 % probability, and ranges with 95 % probability. The annual distribution of the number of surges and ranges showed an average of 12.4 surges and 11.2 ranges per year. The maximum number of surges and ranges was observed in 1981 and was 21 surges and 27 ranges. In the time course of fluctuations of residual levels during the above period, the maximum with the value of 634 cm was noted in 1987 and occurred during the autumn period (ice composition). The length of the surges varied between 0.25 days and 13.5 days. Most of the surges occurred in the period June-October (78.8 %) with the largest number in September (22,8 %). In the period January-May the number of surges decreases to 7.6 % and is zero in April. The lowest ranges residual level was observed in 1986 (343 cm above zero fasting). The total fluctuation of the residual level in New Port during the period of 6-hourly intervals level observations in 1977–1991 was 291 cm. This is 23 cm more than was recorded at the Cape Kamenny station. The length of the ranges varied from 1 day to 8 days. The majority of the intra-annual distribution of the number of ranges over a multi-year period was observed in July–October (83.7 %) with the maximum number in September (28.1 %). A small number of ranges were observed in January and March, and their total absence in April and May. The duration of surges and ranges is inversely dependent on their growth rate. Thus, the highest growth rate of the residual level at the deposit of 5.1 cm/hour corresponds to the duration of the deposit of 0.25 days. The greatest duration of growth of the surge level (9.25 days) corresponds to a speed of 0.14 cm/h. The drop in the level during the range occurred at the highest speed of 11.6 cm/h, the rise from the minimum residual level – at the speed of 6.97 cm/h. Corresponding to these rates, the duration of the decline and rise of the range level was 0.15 cm/h. The highest rise time of the residual range level was 5.25 days at an intensity of 0.44 cm/h.

The authors declare that they have no competing interests.
Spatial location of ice edge in August – September in the Russia’s eastern seas in early 21st century
Authors: Egorov A. G.
Published: March 2020

The goal of the present paper is to analyze the spatial-temporal variability of ice edge location in the Eastern Arctic seas of Russia (the Laptev, East-Siberian and Chukchi Seas) in late summer (August-September) during the period from 1981 to 2018, as well as to estimate the multi-year changes taking place in the 21st century. The special archive containing the information on latitude position of ice edge at the meridians between the Severnaya Zemlya Archipelago and Alaska was developed; the data of AARI (Arctic and Antarctic Research Institute) specialized observations and satellite images were used.

The inter-annual variability of ice edge position in the total area shows that the entire period 1981–2018 consists of two significantly different parts: the interval from 1981 to 2001 with southern ice edge position (mean latitude in September comprised 74,9° N), and the interval from 2002 to 2018 with northern ice edge position (mean latitude 78,7° N). The difference between the extreme values of ice edge latitude at some meridians reached 9 degrees of latitude (about 1000 km).

During the period from 2002 to 2018, the area of mostly active northward displacement of ice edge moved generally from east to west. From 2002 to 2010, the maximum northward displacement of ice edge was observed in the East-Siberian and Chukchi Seas; in 2007 the extreme northern position of ice edge was registered to the east of the New Siberia Archipelago (mean latitude comprised 84,0° N). However, during 2011–2018, the maximum northward displacement of ice edge was observed in the Laptev Sea; in 2014 the extreme northern position of ice edge was registered to the west of the New Siberia Archipelago (mean latitude comprised 84,5° N).

Typologically, the displacement of ice edge from south to north during the period from 2001–2018 looks like a wave; its crest and sole drift from the Chukchi Sea toward the Laptev Sea. Within the period from 2007 to 2010, the ice edge displacement reached its maximum, and after this, during 2011–2015, the reverse motion from north to south began. One can forecast that within the nearest coming years the ice edge oscillatory southward drift would continue, and by the end of 2020-s one can expect the ice edge to have the position typical for the period 2002–2006.

The author declares that he has no competing interests.
Tides in the southern area of the Kara Sea in the vicinity of the Belyi island
Authors: Voinov G. N. , Morozova O. A. , Nesterov A. V. , Kornishin K. A. , Yefimov Ya. O.
Published: March 2020

A number of promising hydrocarbon deposits are known in the south-western part of the Kara Sea. A safe development of these deposits requires hydrometeorological support, including sea-level observations. The paper deals with sea-level data of autonomous anchored buoy station. The period of observation is about 2 years, and the observation dataset is divided into 2 periods due to the displacement of the buoy station. The coordinates of the first position of the buoy station are known but they had been changed after the displacement (possibly due to the action of the ice ridge keels).

Data from two time series of observations are studied by harmonic analysis, using the method of least squares by AARI version. According to the average monthly and mean annual values of the main tides it is found that the data includes two independent series. It is determined that the second series may be considered uniform. In order to locate of the anchored buoy station we calculated new coordinates using the empirical tidal charts of the M2 wave.

As a result, the harmonic constants of the eight main tidal waves for the Belyi Island area are presented for the first time. The new data confirms the amphidromic system in tides O1 and Q1 , between the Zhelaniya Cape and the Belyi Island. According to the new data the maximum seasonal variation in the range of M2 tide was observed in June, and the minimum of the phase angle was observed in July. This unusual seasonal variation of the M2 tide corresponds to previous observations data from the Uedinenia Island.

The authors have no competing interests.
Research of R/V “Akademik Tryoshnikov” hull structures response to ice actions during the first stage of the expedition “Transarktika-2019”
Authors: Maksimova P. V. , Chernov A. V. , Likhomanov V. A. , Krupina N. A. , Likhomanov V. A.
Published: March 2020

At present, oil-producing offshore structures, as well as transport vessels transporting oil products extracted in the seas of the Russian Arctic are equipped with ice load monitoring systems (ILMS) to prevent environmental disasters. The ice-resistant self-propelled platform (IRSPP) that is under construction now, according to the design should be equipped with this system. First of all this system is the main system for ensuring the platform’s safety in ice conditions, and secondly makes the platform’s hull a unique tool for solving a wide range of tasks to study the effects of ice on any construction.

The main goal of the research during the expedition “Transarktika-2019” was to obtain the necessary data for the development of an ice load monitoring system of the constructing IRSPP “North Pole” and testing the prototype of the ILMS at long vessel’s drift in ice.

The measurements of stresses in the hull structures of the R/V “Akademik Tryoshnikov” were carried out during impacts on ice ridges and during ice compressions.

The standard ship ice load monitoring system (SILMS) of the R/V “Akademik Tryoshnikov” and strain gauges additionally installed on the frames and a shell plating in the middle part of the hull were used to perform the measurements.

The analysis of the obtained data showed that the maximal loads on the hull occurred during the forcing of ice ridges but the level of maximum stresses was not a danger to the hull.

Compressions during the drift did not have a strong effect on the ship’s hull. The data obtained made it possible to identify a number of features for the operation of ILMS in similar conditions.

Based on the results of the expedition research, recommendations for the design of the architecture of the ILMS for IRSPP were issued. The results of further analysis of the obtained materials will be used in the development of data processing algorithms for ILMS for IRSPP, as well as for the development of the prospective programs of scientific research of deformation, fracture and other processes of various scales that occur in drifting ice during the future drifts of the IRSPP “North Pole”.

The authors have no competing interests.
Evaluating Intrahepatic and Intraperitoneal Sodium Pentobarbital or Ethanol for Mouse Euthanasia
Authors: Laferriere Colin A , Leung Vivian SY , Pang Daniel SJ
Published: March 2020

Intraperitoneal (IP) injection of sodium pentobarbital (PB) is an accepted method of euthanasia for mice. However, this method has important drawbacks, including the potential for pain or misinjection. The objective of this prospective, randomized, blinded study was to determine whether
intrahepatic (IH) injection of PB is more effective than IP delivery for mouse euthanasia. Secondary objectives were to: 1) determine whether IP ethanol (ET) is a suitable alternative to PB and 2) study the effect of isoflurane anesthesia on euthanasia with either PB or ET. Eighty adult CD1
mice were randomly assigned to 6 different treatment groups, were euthanized by using IP or IH injections of either PB or ET, and were either anesthetized or conscious before injection. Variables of interest were: 1) misinjection rates (based on necropsy evaluation), 2) time from injection
to apnea and 3) time to cessation of heartbeat (CHB). The misinjection rate for IH injections was 93% (28/30). Two successful IH injections resulted in death within 4 s, but this method cannot be recommended due to the possibility for intrathoracic injection ( n = 4). In nonanesthetized
mice, time to apnea and CHB was significantly shorter with IP ET (apnea: 72.5 s [median], CHB: 115 s) than with IP PB (apnea: 136 s, CHB: 176 s). Anesthesia at time of injection was associated with a shorter CHB time for IP PB. These data show the difficulty in achieving successful IH injections
in mice, but confirm that IP ET is a viable and potentially superior alternative to IP PB. Lastly, anesthesia can shorten time to death after IP injection of PB.
Drug-Induced Heart Failure (Part 1: The Urgency of the Problem, the Prevalence, the Effect of Certain Groups of Drugs on the Risk of Development/Progression Heart Failure)
Authors: Ostroumova O. D. , Goloborodova I. V.
Published: March 2020

Despite all the achievements of modern medicine, heart failure remains one of the most prevalent, severe and prognostically unfavorable conditions that requires close attention of the medical community. The diversity of the clinical picture and the large number of co-morbidities go hand in hand with a rather complicated pharmacotherapy regimen which, in the vast majority of cases, includes several medicines. Some classes of drugs can provoke the onset/progression of heart failure in patients with left ventricular dysfunction, as well as contribute to the development of heart failure in patients without concomitant cardiovascular diseases. The aim of the study was to analyse and systematise data on risk factors for the development of drug-induced heart failure and data on its prevalence when using various groups of medicines. It has been established that drug-induced heart failure typically develops in association with the use of calcium channel blockers (verapamil, diltiazem, nifedipine), beta-blockers (propranolol), antiarrhythmic drugs (disopyramide, dronedarone, lidocaine, lorcainide, mexiletine, moricizine, propafenone, tocainide, ﬂecainide, encainide), hypoglycemic drugs (rosiglitazone, pioglitazone, saxagliptin), anthracyclines (doxorubicin, epirubicin) and other anticancer drugs (bevacizumab, inﬂiximab, trastuzumab), and non-steroidal anti-inﬂ ammatory drugs (diclofenac, ibuprofen, celecoxib, rofecoxib). It is assumed that this pathology develops in a small number of patients, mainly those who already have left ventricular dysfunction. However, the effects of drugs should be considered as one of potential and preventable causes of heart failure development/progression. Raising clinicians’ awareness of the potential adverse effects of individual medicines or entire pharmacological classes of drugs on the cardiac function, especially in patients with left ventricle dysfunction, can facilitate the timely diagnosis and prevention of drug-induced heart failure.
Immune Response Checkpoint Inhibitors: New Risks of a New Class of Antitumor Agents
Authors: Shubnikova E. V. , Bukatina T. M. , Velts N. Yu. , Kaperko D. A. , Kutekhova G. V.
Published: March 2020

The introduction into clinical practice of immune checkpoint inhibitors that block cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein-1 (PD-1), and programmed cell death ligand-1 (PD-L1), has improved the prognosis of patients with malignant neoplasms of diﬀ erent localisation. The antitumour eﬀ ect of immune checkpoint inhibitors is based on blocking CTLA-4 and PD-1/PD-L1 signaling pathways and enhancing lymphocyte antitumour activity. However, inhibition of immune checkpoints may lead to dysregulation of immune responses and appearance of a new type of adverse reactions resulting from changes in the activity of immunocompetent cells. The aim of the study was to analyse adverse reactions associated with the use of immune checkpoint inhibitors. It was demonstrated that the structure of immune-mediated adverse reactions varied depending on the class of immune checkpoint inhibitors. The incidence of immune-mediated adverse reactions was higher with CTLA-4 inhibitors as compared with PD-1/PD-L1 inhibitors, and increased signiﬁ cantly in the case of combination therapy. The treatment with CTLA-4 inhibitors most often resulted in skin reactions (rash, itching), gastrointestinal tract reactions (diarrhea, colitis), and endocrine gland problems (hypophysitis). The treatment with PD-1 inhibitors most often led to respiratory disorders (pneumonitis), and in some cases to gastrointestinal disorders (diarrhea, colitis), skin reactions (rash, itching), and endocrine gland problems (hypothyroidism), but they were less common. The treatment with PD-L1 inhibitors was associated with the development of pneumonitis. The development of immune-mediated adverse reactions may require discontinuation of treatment and administration of immunosuppressants, therefore early diagnosis and timely treatment of complications are important prerequisites for successful antitumour therapy. Further study of the mechanisms of immune-mediated adverse reaction development will optimise antitumour therapy with immune checkpoint inhibitors.
Relasi Prinsip Tauhid dalam Ekonomi Islam terhadap Pemikiran Etika Murthada Muthahari
Authors: Hasan Nugraha
Published: March 2020

Ethics is an interesting discussion because the principle recognizes ethical values, such as fairness and honesty. Ethics give instructions to humans how to do good and avoid the bad. This research is a type of qualitative research and includes literature studies using literature, in the form of books, articles, and the results of previous research. Data obtained through literature review are direct and indirect quotations. Human ego which cannot be controlled will damage the value system that God has created. God created man to carry out the task of khalifah on earth. Where humans must protect and prosper the earth. So in running the wheel of the human economy must pay attention to all aspects so as not to conflict with Islamic values. All forms of cheating or fraud and negative actions are strictly prohibited in Islamic economics. This is an important point of the caliph's principle, which apply Islamic values in the running of the economy for human life. The results of this paper state that tauhidad is the root of the moral principles of the faithful that cannot be uprooted by any power. When the feeling of the subconscious turns into conscious, then all human actions can be categorized as moral deeds. That is what is reflected in the person of the holy men.
Pengaruh Motivasi terhadap Produktivitas Kerja Karyawan PT. Telkom Tbk Cabang Makassar
Authors: Nurnaningsih Nurnaningsih , Tabe Ridwan
Published: March 2020

Effects of Motivation on Work Productivity of PT. Telkom Tbk Employees in Makassar Branch. The purpose of this study is 1) To determine the effect of employee motivation (External and Internal) on Employee Productivity at PT. Makassar Branch Telkom, 2) To find out which motivation is more dominant in influencing employee work productivity at PT. Telkom Makassar Branch. Data used in this study are primary and secondary data. Population in this study are all employees who work at PT. Telkom Tbk Makassar Branch, amounting to 540 people. Determination of samples using a simple random sampling technique which if the number of research subjects is less than 100, it is better to take all but if the subject is large then only 10% is taken so the total population taken is 54 people. The analytical method used in this study is multiple linear regression analysis using SPSS. The results showed that: 1) External Motivation in PT. Telkom companies had a significant influence on performance productivity based on employee perceptions, 2) From the results of the analysis, the results showed that external motivation (Working Conditions, Good Bosses, Financial and Social Guarantees) had an effect towards the productivity of the company. While the analysis obtained from internal motivation (Exciting Work, Challenging Work, and Attractive Work) has an influence on productivity. Thus, the proposed hypothesis is proven, 3) External and internal motivation has a simultaneous effect on employee performance. This is evidenced by the coefficient of determination test, which is equal to 47% of employee performance is influenced by variations in the two variables used in the study, the remaining 53% is influenced by other factors, 4) External motivation is more dominantly influencing employee performance this is evidenced by external motivation regression coefficient greater than internal motivation, 5) Internal motivation is the most dominant influence on productivity is good communication between employees and supervisors of internal motivation is the work performance that is owned based on the research conducted.
Internalisasi Goal Congruance untuk Pendeteksian Financial Statement Fraud Berbasis Behaviour Audit (Studi Kasus KAP Benny dan Rekan)
Authors: Majid Jamaluddin , Fani Alfian , Gama Marwah
Published: March 2020

This research aims to reveal goal congruence for the financial statement fraud- based behavioral audit. financial statement fraud. The agency relationship theory is a contract between the auditor (agent) and the principal (principal). Agency relationships arise when one or more principals employ another person (agent) to provide a service and then delegate authority to decision making to the agent. This study was conducted at KAP Benny and colleagues using qualitative research using phenomenology approach using secondary data and primary data analyzed using interview and interview method using tools in the form of recorder and manuscript aid and tested its validity. The result of this research is shown by case from from 2015 to 2017. In 2015 there was 86.3% of cases, in 2016 there was 86.7% and down in 2017 by 3.68%. Auditors' perception of goal congruence can help in achieving the goal of information that is not synchronized with other information. For that in building a good goal congruence then we need to build the ethics of an auditor.
Distribution in Islamic Economic Perspective (Critics to Capitalist)
Authors: Samad Telsy Fratama Dewi
Published: March 2020

Distribution is one of the economic topics that is necessary to be discussed, mainly the distribution of wealth because it concerns the effort to achieve prosperity for all levels of society in a country through equitable distribution of wealth. In this article, we will discuss the concept of wealth distribution both from conventional perspective, which is based on capitalist ideology and from the perspective of Islamic economics. As the public understanding about capitalism, it is one of the economic comprehension carried by the Father of Economics "Adam Smith" which emphasizes the individual freedom in managing assets without government intervention. Capitalism has led to injustice and income inequality in the community, causing conflict and creating permanent poverty for the citizens of society. Islam refers the process of distribution of wealth following Islamic principles. Islam prevents the accumulation of wealth in certain small groups and promotes the distribution of wealth to all levels of society. This research is descriptive qualitative based on the study of literature such as books and other literature that are relevant to the problems considered by the author. The purpose of this study is to understand the concept of wealth distribution based on Islamic economic and capitalist economic perspectives. The result of this article concluded that the capitalist wealth distribution system should be replaced by the Islamic economic system that emphasizes the value of freedom as well as the behaviour of human based on religious teachings and the value of justice in ownership.
Komparasi Fee Based Income pada Bank Konvensional dan Bank Syariah di Indonesia (Studi Laporan Keuangan)
Authors: Niu Fitria Ayu Lestari , Hasan Youlanda
Published: March 2020

Fee-based income which is another operating income is proportional to the banking operational income. The elements of operating income included in the group fee based income are commission and provision income, income from foreign exchange or foreign exchange transactions and other operating income. This study aims to describe the comparison of the acquisition of fee-based income in conventional banks and Islamic banks by using secondary data in the form of financial reports in 2014-2015 which were analyzed for comparison using ananalysis intercompany basis through a descriptive quantitative approach. The results showed that the comparison of fee-based income in the conventional bank group was surpassed by Bank Mandiri, which was able to achieve the highest fee-based income compared to BRI and BNI in the 2014-2018 period. Whereas the sharia bank group was outperformed by Bank Syariah Mandiri with the highest fee-based income compared to BRIS and BNIS in the 2014-2018 period. The acquisition of fee-based income in the conventional bank group compared to Islamic banks was outperformed by Conventional Banks namely Bank Mandiri, which each year significantly won the fee-based income highest. Whereas in the proportion of fee-based income to operating income at conventional banks, Bank Mandiri was still in the first position with the highest proportion of 28.61%, followed by BNI in the second position and BRI in the third position. As for Islamic banks, the average proportion of fee-based income to operating income was also occupied by Bank Syariah Mandiri with a gain of 12.89%, followed by BRIS in the second position with 4.84% and the last BNIS of 3.71%.
Assessment of risk factors for multifocal atherosclerosis in the workers of the main professions of coal enterprises in the South of Kuzbass
Authors: Filimonov E. S. , Korotenko O. Yu. , Rumpel O. A. , Blazhina O. N.
Published: March 2020

Introduction. The problem of high mortality from cardiovascular diseases is caused, among other things, by asymptomatic atherosclerosis, which proceeds latently for a long time and manifests itself as a serious vascular catastrophe, which is of particular importance for people working at production facilities with difficult and dangerous working conditions.

The aim of the study was to assess the risk factors for atherosclerosis and the state of the vascular wall in the workers of the main professions of coal enterprises in the South of Kuzbass.

Material and methods. In total, the study included 384 people (men), of whom 266 were the workers in coal mines in the South of Kuzbass and 118 people who were not employed in the coal industry, aged 40 to 55 years. The diagnosis of atherosclerosis was carried out on the ultrasound system “Vivid E9” of the manufacturing company GE using a linear sensor for measuring the thickness of the intima-media complex and visualization of atherosclerotic plaques. To identify significant risk factors, anthropometric, anamnestic data, indices of lipid and carbohydrate metabolism, and the presence of arterial hypertension were studied.

Results. Significant differences in the frequency of asymptomatic atherosclerosis in the form of an increase in intima-media thickness by more than 1 mm and / or the presence of atherosclerotic plaques in both groups were not found: 60.2% among the miners and 62.3% among non-coal mining workers (p=0.703); at the same time, the percentage of detection of atherosclerotic plaques in arteries was significantly lower among coal workers — 46.9% versus 60.5% among people in the comparison group (p=0.016). The common risk factors for all examined subjects were arterial hypertension and increased level of glycated hemoglobin; in turn, in coal miners additional risk factors were increased values of low density lipoproteins and waist-hip index, as well as burdened heredity for cardiovascular diseases, and among the individuals not employed in the coal industry it was smoking.

Conclusions. The most significant risk factors for atherosclerosis in coal industry workers were arterial hypertension, raised values of glycated hemoglobin, low density lipoproteins and waist-hip index, as well as burdened heredity for cardiovascular diseases. Significant differences in the frequency of asymptomatic atherosclerosis in the form of an increase in the thickness of the intima-media complex of the main arteries and the presence of atherosclerotic plaques in both groups were not established, but the percentage of the detection of atherosclerotic plaques was lower among coal miners.

The authors declare no conflict of interests.
Influence of violations of autonomic regulation on the development of occupational polyneuropathy of the upper extremities in Kuzbass miners
Authors: Gidayatova M. O. , Fleishman A. N. , Yamshchikova A. V. , Martynov I. D.
Published: March 2020

Introduction.Active coal mining in Kuzbass, with its unfavorable climatic and environmental conditions, necessitates the study of occupational diseases of workers in this industry. One of the most common occupationally caused diseases of miners is polyneuropathy of the upper extremities.

The aim of the studyis to assess the effect of autonomic disorders on the course of occupational upper limb polyneuropathy in workers of the Kuzbass coal industry using various methods of analyzing heart rate variability.

Materials and methods. 52 employees of coal enterprises aged from 43 to 64 years with the established diagnosis of “polyneuropathy of the upper extremities” were examined. The control group consisted of 16 healthy volunteers of the same age, engaged mainly in mental or light physical labor. Electroneuromyography was performed to assess the degree of damage to peripheral nerve fibers. Spectral and nonlinear parameters of heart rate variability were used to determine the state of autonomic regulation. The Mann-Whitney criterion was used to assess the statistical significance of differences between the study groups.

Results.3 groups of patients with polyneuropathy were identified according to the severity of violations of impulse conduction in the peripheral nerves. In subjects with mild, initial disturbances of pulse conduction (n=8, 15.4%), a decrease in parasympathetic influence is determined, which is manifested by a statistically significant decrease in the power of high frequency oscillations of the heart rate variability spectrum. With moderate signs of polyneuropathy (28 cases, 53.9%), there is a shift in the autonomic balance towards sympathetic activation; a statistically significant increase in very low-frequency fluctuations in heart rate variability indicates an increase in the influence of suprasegmental autonomic centers. In subjects with gross violations of the peripheral nerve impulses (n=16, 30.7%), there is a decrease in the power of oscillations in all frequency ranges of heart rate variability.

Conclusions. The obtained data confirm the influence of autonomic regulation on the course of occupational polyneuropathy.

The authors declare no conflict of interests.
Relationship of subdepressive symptoms with phases of emotional burnout in representatives of “assisting professions”
Authors: Vlakh N. I. , Danilov I. P. , Gugushvili M. A. , Paneva N. Ya. , Logunova T. D.
Published: March 2020

Introduction. The study of the problems of human stress resistance in various professions has shown that prolonged exposure to stress leads to such adverse consequences as a decrease in the overall mental stability of the body, the emergence of a sense of dissatisfaction with the results of their activities, the tendency to refuse to perform tasks in situations of increased demands, failures and defeats. Analysis of the factors that cause such symptoms in various activities has shown that there are a number of professions in which a person begins to experience a sense of internal emotional emptiness due to the need for constant contact with other people.

The aim of the study is to study the subdepressive symptoms in accordance with the phases of emotional burnout.

Materials and methods. The study involved 465 people, of whom 219 men and 246 women were representatives of various professional groups. The indicators of emotional burnout, including three phases-stages: “Tension”, “Resistance”, “Exhaustion” — each of which consists of 4 symptoms, are considered.

Results. The correlation coefficient of the level of formation of symptoms of emotional burnout according to the method of V.V. Boyko with the level of severity of each of the components of emotional burnout according to the MBI method are calculated.

Conclusions. It was found that people whose personal and professional lives are filled with meaning are only slightly or moderately susceptible to burnout syndrome. On the contrary, subjects with an existential vacuum showed, according to the MVI test, a high degree of severity of burnout syndrome.

The authors declare no conflict of interests
Effectiveness of ischemic preconditioning for correction of neuroautonomic disorders in vibration disease
Authors: Yamshchikova A. V. , Fleishman A. N. , Gidayatova M. O.
Published: March 2020

Introduction. Vibration disease, affecting the autonomic-vascular regulation at different levels, disrupts the balance of sympathetic and parasympathetic influences with the formation of vasospasm. The development of cardiac autonomic neuropathy leads to a worsening of the prognosis for the life of patients, and therefore, the search for effective methods for correcting autonomic disorders is an urgent task in the treatment of vibration disease.

The aim of the study is to evaluate the effectiveness of ischemic preconditioning for the correction of neurovegetative manifestations of vibration disease.

Materials and methods. A comparative assessment of the initial parameters of heart rate variability was carried out in the main group of patients with an established diagnosis of vibration disease (32 people), and in the control group (25 people who had never worked under the influence of industrial vibration). The main group of patients underwent ischemic preconditioning of the upper extremities for 4 days, followed by monitoring of heart rate variability. The Mann-Whitney criteria were used to compare two independent samples and Wilcoxon to assess the significance of changes in indicators before and after exposure. Values at p<0.05 were considered statistically reliable.

Results. An initial decrease in the power level of all spectral parameters of heart rate variability in the main group with the formation of relative sympathicotonia and a decrease in the values of the approximated entropy was revealed. After ischemic preconditioning, heart rate variability significantly increases, which indicates a decrease in the severity of autonomous neuropathy and an improvement in the prognosis for life.

Conclusions. In patients with vibration disease, all parts of the peripheral and central autonomic nervous system are involved in pathogenesis with the formation of persistent sympathicotonia and violation of regulatory mechanisms. Ischemic preconditioning can affect the identified disorders by inducing an adaptive vagal response.

The authors declare no conflict of interests.
Radonotherapy in restoring statokinetic functions in the patients with occupational joint damage
Authors: Gordeeva R. V. , Filimonov S. N. , Kuzmenko O. V. , Kireeva L. N. , Martynova E. A. , Anishchenkova T. I.
Published: March 2020

The results of the use of natural radon water in the form of general baths in patients working in the coal mining and metallurgical industry, with occupational diseases of the joints and spine, at the stage of rehabilitation are presented. Studies have shown that the course application of radon therapy has a pronounced analgesic and anti-inflammatory effect, a general sedative effect helps to restore the volume of movements in the affected joints, normalizes the statokinetic functions of the musculoskeletal system, slows down the progression of the joint process and the development of dystrophic changes in the musculoskeletal system.

Indicators of statodynamic functions of the musculoskeletal system in patients with occupational diseases of the joints and spine in the rehabilitation system against the background of course use of natural radon waters in the form of shared baths were studied. The aim of the study is to explore the effect of radon waters of natural origin on the dynamics of statodynamic parameters according to the data of a stabilometric study in patients working in the coal mining and metallurgical industry, with occupational diseases of the joints and spine.

Patients with occupational diseases of the joints and spine in rehabilitation were prescribed general radon baths (the main group). The control group of patients received freshwater baths. Before and after treatment were carried out studies of the static-dynamic functions stabiiloplatform (soft ware-hardware complex for clinical motion analysis “Biomechanics” published by the scientific-medical firm MBN), with the help of which the indicator of the common center of mass, the flexor setting up of the thigh, the coefficient of weight load on the foot, the inter-limb asymmetry, the vertical stance was determined in the initial position and in the Romberg position.

The use of common radon baths in the main group allowed to normalize the statokinetic functions of the musculoskeletal system in the form of reducing the period of alignment of the pelvic flexor installations and asymmetry of the distribution of weight load on the affected limb; increasing the level of adaptation of patients to functional loads against the background of reducing pain and inflammatory syndrome. There were no significant changes in these indicators in the control group. The use of general radon baths on the rehabilitation stage in patients working in the coal mining and metallurgical industry, with occupational diseases of the joints and spine, helps to restore the statodynamic functions of the musculoskeletal system, the disappearance of pain syndrome, and reduces inflammation.

The authors declare no conflict of interests.
On the issue of manganese intoxication
Authors: Gavrylyshena K. V. , Gurevich E. B. , Semenikhin V. A. , Strizhakov L. A. , Filimonov S. N. , Chasovskikh E. V.
Published: March 2020

Currently, the proportion of workers exposed to manganese compounds is quite high, but due to increased safety measures and changes in working conditions, the number of new cases of chronic occupational manganese intoxication has decreased significantly. an attempt has been made

An attempt has been made to highlight the difficulties of differential diagnosis of occupational chronic manganese intoxication and other neurological diseases on the example of clinical cases of examination of persons with extrapyramidal system lesions in the form of early development of Parkinson’s disease. The assessment of complaints, medical history, neurological status, laboratory tests, and instrumental studies to find the probable cause of Parkinsonism was carried out. The interest of the observations lies in the difficulty of interpreting the data obtained and the importance of studying the professional route of patients. Magnetic resonance imaging of the brain, electromyography of the extremities, electroencephalography, echoencephalography, the study of the concentration of metabolites characteristic of Niemann-Pik disease, copper indicators in the blood help in making a correct diagnosis.

When examining a contingent of people working in contact with manganese compounds, if they suspect chronic occupational manganese intoxication, it is important consider other diseases that lead to the development of Parkinson’s disease.

The authors declare no conflict of interests.
Universal mobile protection system for aerosol‐generating medical interventions in COVID-19 patients
Authors: Straube Florian , clemens wendtner , Volz Stefan , Dorwarth Uwe , Engel Markus , Schneider Niklas , Lärmer Jürgen , Nagel Bernhard , Friederich Patrick , Fisch Richard , Rieß Alexander , Benedikter Josef , Meyer Joachim , Lewerenz Bjoern , Schepp Wolfgang , Schmid Mathias , Dodt Christoph , Schmidt Wolfgang , Weidenbach Katrin , Rogowski Sebastian , Kossmann Hans , Berger Manuel , Gatos Konstantin , Würstl Benjamin , Deichstetter Markus , Ellen.Hoffmann@muenchen
Published: March 2020

A universal, mobile protection system for work close to patients suffering from acute infectious diseases with aerosol formation has been developed. It is considered useful by the main medical disciplines involved in the treatment of CoVid patients. In those times, disposable protection gear is scarce, and the robust, reusable protection system might be helpful for medical personnel to work more safely in vulnerable situations.
Metagenome of SARS-Cov2 from a patient in Brazil shows a wide range of bacterial species - Lautropia, Prevotella, Haemophilus - overshadowing viral reads, which does not even add up to a full genome, explaining false negatives
Authors: Chakraborty Sandeep
Published: March 2020

LetterHere, I analyze the metagenome from the nasopharyngeal swab of a suspected case of local transmission of Covid-19, in Brazil (Accid:PRJNA613951).Very little viral load, not covering the entire genomeThere are just 152 reads matching to SARS-Cov2 [1] (SIbrazil/SARS-Cov2.reads.fa), which adds up a total of 21190 bp, much lesser than the 30000bp SARS-Cov2 genome. This is a very plausible cause for false negatives, there is just not enough virus to detect.For eg, if the RT-PCR test was looking for a genomic fragment in the spike protein (3879bp) from 369– 1174, it would not find a match. Thus, it is important to use multiple primers spread across the genome, something which the CDC test does not do.Much more bacterial load - Lautropia, Prevotella, Haemophilus dominatingThere are a wide range of bacteria (SIbrazil/allbact.list.txt,n=117) - Lautropia, Prevotella, Haemophilus dominating (Table 1). These are the same bacteria found in China [2] and San Diego county [3]. There are 10851 reads matching to bacteria (SIbrazil/allbactsequences.fa). These bacterial co-infections form the basis of hydroxychloroquine and azithromycin working in clinical trials [4].
Hoạt động chiêu thị ảnh hưởng đến giá trị thương hiệu Vietjet Air
Authors: Giao Ha Nam Khanh , Phuoc Ngo Duc
Published: March 2020

Nghiên cứu nhằm đánh giá tác động của các hoạt động chiêu thị đến một số thành phần giá trị thương hiệu của hãng hàng không Vietjet Air, bằng việc khảo sát 385 hành khách đã sử dụng dịch vụ vận tải Vietjet Air. Phương pháp đánh giá độ tin cậy Cronbach’s Alpha, phân tích nhân tố khám phá (EFA), phân tích nhân tố khẳng định (CFA), mô hình cấu trúc tuyến tính (SEM) được sử dụng với sự trợ giúp của các phần mềm SPSS và AMOS. Kết quả nghiên cứu cho thấy các hoạt động chiêu thị tác động cùng chiều đến nhận biết thương hiệu theo thứ tự độ quan trọng giảm dần: bán hàng trực tiếp, quảng cáo, khuyến mãi, quan hệ công chúng; tác động cùng chiều đến trung thành thương hiệu theo độ quan trọng giảm dần: bán hàng trực tiếp, quan hệ công chúng. Bên cạnh đó, nhận biết thương hiệu cũng tác động cùng chiều đến trung thành thương hiệu. Từ kết quả nghiên cứu, một số hàm ý quản trị trong hoạt động chiêu thị được gợi ý đến ban quản lý Vietjet Air nhằm nâng cao sự nhận biết và trung thành thương hiệu của khách hàng.
The assessment of urban heat island effect and mitigation countermeasures
Authors: Chou Yu-Ching
Published: March 2020

Owing to the urban heat island effect, the urban design and planning have been encountered the severe plights. Based on our observational research show that each year in Taiwan during the summer season, the urban and rural area temperature difference of up to 3-8 ℃; our numerical simulation results show the environmental thermal forcing effect is quite significant during the occurrence period of the urban heat island effect. And environmental wind field was forced to change (from the original northwest wind to southwest wind), a rapid increase in the moisture field (the relative humidity up to 90％), convergence was forced in the low level, upward motion derivative is excited, and result show the unexpected afternoon thunderstorms phenomenon occurred on the urban region.On the vicinity of the architecture building or the urban construction region, planting the large arbor that the carbon sequestration force was strong (about 900 kg / m2 / yr), by thinking about to adjust planting location, direction, height, area, density, and design, to guide the suitable environmental wind field, it will effectively mitigate the urban heat island effect.
Active Surveillance for COVID-19 through artificial intelligence using concept of real-time speech-recognition mobile application to analyse cough sound.
Authors: IQBAL MOHAMMAD ZAFAR
Published: March 2020

In view of recent coronavirus (SARS-CoV2) outbreak, we propose a novel model of active surveillance for COVID-19 through artificial intelligence. Both past and recent events of viral disease outbreaks have shown us that we do not have effective methods to screen the whole population and efforts are failing to stop the pandemics. Moreover, at this stage, social distancing and home quarantine are only measures to stop the spread of COVID-19 infection. The purpose of our project is to introduce a robust method of using speech-recognition techniques through a mobile application in analysing cough sounds of suspected people, who previously were healthy, suffering from a respiratory ailment and actively monitor the progress of their symptoms in real-time. The mobile application will give feedback to the app users on a routine basis and advise to take medication and necessary precautions to avoid spreading of the infection. The app will also notify the local healthcare facilities about sick users or vice-versa if their symptoms deteriorates. A feedback will be sent to an app-centre notifying the number of both new and old sick users appeared in a particular region. With the data compiled at the app-centre, we will also be able to trace the disease spread patterns, categorise the regions in three levels- mild, moderate and severe based on the number of sick users and deploy the resources accordingly to stop the transmission hence, preventing unnecessary use of both human and medical resources to stop the infection in redundant regions.
The molecular basis of loss of smell in 2019-nCoV infected individuals
Authors: Gupta Krishan , Mohanty Sanjay Kumar , Kalra Siddhant , Mittal Aayushi , Mishra Tripti , Ahuja Jatin , Sengupta Debarka , Ahuja Gaurav
Published: March 2020

Among the prominent clinical symptoms such as fatigue, shortness of breath, fever, and cough, 2019-nCoV infected individuals often experience hyposmia/anosmia (decrease or loss of sense of smell). Angiotensin I Converting Enzyme 2 (ACE2), a key host receptor has now been established as an important moiety for the entry of 2019-nCoV into the host cells. A multitude of studies estimated the expression of ACE2 in multiple organs including heart, kidney, intestine, lungs, buccal cavity, etc. The ongoing medical examinations and the autopsy reports of the diseased individuals strongly corroborate these organ/tissue-level molecular insights. Olfactory mucosa harbors multiple functionally distinct cell types. Zeroing in on the cell lineages that underpin infection associated loss of olfaction may provide new leads for diagnostics/clinical management of 2019-nCoV infected individuals. Our pointed bioinformatic analysis of single-cell expression profiles underscored selective expression of ACE2 in a subset of sustentacular cells (SUSs), Olfactory Stem cells (HBCs and GBCs), and Bowman’s gland cells of the olfactory mucosa in humans. Co-expression analysis of ACE2 and TMPRSS2 (protease), two host-specific moieties indispensable for 2019-nCoV entry into the host cell revealed the highest infection susceptibility for the sustentacular cells. Additionally, an inspection of the ACE2 and TMPRSS2 levels in the olfactory mucosa of 4 additional mammalian species revealed comparable expression patterns, indicating the potential risk of olfactory dysfunction in these species. In summary, our findings pinpoint the molecular rationale of loss of smell in 2019-nCoV infected patients.
preprint title
Authors: salsabila novialindra chika
Published: March 2020

UNDERSTANDING OF DATA STRUCTURES
PELAKSANAAN UUD 1945 (REFORMASI) DALAM PERSPEKTIF KETATANEGARAAN
Authors: HI RISKI PUTRA UTAMA
Published: March 2020

Pelaksanaan dinamika UUD 1945 pada orde reformasi masih banyak penyimpangan yang terjadi karena pada masa ini belum semua UUD 1945 dilaksanakan dan masih adanya korupsi, kolusi dan nepotisme. Sehingga memunculkan orde ini terjadi krisis ekonomi, krisis social, krisis politik dan krisis hukum.
Dewi Ratna Sari
Authors: Sari Dewi Ratna
Published: March 2020

Resume implementation About Article of Hubungan Algoritma dan Struktur Data Dalam Pemprograman