bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating network pharmacology and molecular docking for the identification of key genes and therapeutic targets of Nigella sativa in multiple sclerosis treatment
Authors: Kapadia Hardi , Vora Divya , S. Manjegowda Dinesh , Nair Ajay , Sharma Sameer , Dinesh Susha
Published: July 2023

Introduction and Aim: Multiple sclerosis (MS) is a chronic neurodegenerative disease affecting around 2.8 million people worldwide. MS pathophysiology is not yet explained up to the mark, which is the cause of difficulty and complexity in treating the illness. Most present-day scenarios are engrossed in inhibiting central nervous system (CNS) inflammation. However, this is not enough, hence the present study aims at finding best neuroprotective treatment without adverse effects.
 
Materials and Methods: In silico attempt to validate the phytocompounds from Nigella sativa and showcase their use for targeting the neuroprotective mechanism involved in management of MS by finding the key potential genes which were derived from mRNA datasets of previous research. Various bioinformatics tools and software such as GEO, String, ShinyGO, PyRx were used to carry out the current study. The leading steps involve retrieval of targets from mRNA datasets, molecular docking of phytocompounds with the targets and pharmacological analysis.
 
Results: These phytocompounds from seeds of N. sativa showed promising results as therapeutic agents against target genes RPL27, RPS14 and FAU for management of MS during current in silico study, but any treatment prior its clinical practice should validate with large robust data, which lies as the future prospective here.
 
Conclusion: In summary notable progress in management of MS with better understanding of pathology has been made and many disease modifying therapies (DMT) are made available but the question of safety and efficacy is still challenging due to adverse effects associated with these therapies. Hence properties of N. sativa must be explored as a therapeutic agent that can reduce the neuronal degeneration.
Analysis of Financial Performance Before and After the Pandemic Covid-19
Authors: Rachmatullah Muhammad , Haliah Haliah , Kusumawati Kusumawati
Published: July 2023

The purpose of this study was to analyze the financial performance before and during the Covid-19 pandemic in automotive and component sub-sector companies listed on the Indonesia Stock Exchange. This study uses financial ratio analysis by testing hypotheses using paired sample t-tests and using data collection techniques in the form of financial statement searches and literature studies. The results showed that there were no significant differences in the current ratio and debt-equity ratio between the period before the covid-19 pandemic and during the covid-19 pandemic, there were significant differences in return on assets and total asset turnover between the period before the covid-19 pandemic and during the covid-19 pandemic.Keywords: Covid-19 Pandemic, Current Ratio, Debt Equity Ratio, Return On Assets, Total Asset Turnover
Build Back Better: Rehabilitation And Reconstruction After The Cianjur Earthquake Disaster
Authors: Ihsan Muhammad , Marnani Christine S. , Bahar Fauzi
Published: July 2023

Geographically, Indonesia is located in an area with a tropical climate, making Indonesia a country prone to disasters. Located within the Pacific Ring of Fire (volcanic arc), 76 out of 147 volcanoes in Indonesia have active status making this country the most disaster-prone place in the world. In recent years, various earthquake activities have been recorded in Indonesia, one of which occurred in Cianjur on November 21, 2022. The Cianjur earthquake was caused by active fault activity of the Eurasian plate with a shear fault type, a shallow crustal earthquake which caused the damage so big. This study aims to identify the development of earthquake resistant houses with RISHA technology (Simple Healthy Instant Houses) for sustainable development. This study used a qualitative approach with documentation data collection methods and data analysis using descriptive methods. The results of this study are sustainable post-disaster management in accordance with what is stated in the 2015-2030 Sendai Framework, namely build back better. Construction of permanent housing in Cianjur using RISHA earthquake resistant housing technology as a form of mitigation or preventing the occurrence of new disaster risks and reducing existing disaster risks while still paying attention to the living conditions and livelihoods of the local community.
Meios de fixação mais utilizados em fraturas de ângulo mandibular
Authors: Franck Felipe Calile , Oliveira Junior Paulo Afonso de , Vitale Marcelo , Pino Danilo Siqueira , Dias Francisco José de Nadai
Published: July 2023

A mandíbula, apesar de ser um osso resistente e pesado, está sujeita a fraturas por se localizar na região inferior da face. Em casos de acidentes de trânsito, pela brusca força gerada na movimentação da cabeça, a mandíbula absorve esta força e a projeta na face. Embora 40% de todas as fraturas de face sejam na mandíbula, sendo 21% delas na região de ângulo mandibular, o tratamento ideal para este tipo de fratura ainda é controverso. Exis-tem duas filosofias diferentes que os cirurgiões se fundamentam para a escolha da técnica a ser realizada no tratamento de fratura na região de ângulo mandibular (FAM): o primeiro grupo segue os  mandamentos da AO/ASIF (Arbeitsgemeinschaft für Osteosynthesefra-gen), que acredita que os fragmentos da fratura devem ser totalmente imobilizados, ou seja, deve-se utilizar um método rígido; já o segundo grupo acredita nos fundamentos da técnica desenvolvida por Champy, em que o meio de fixação deve ser semirrígido, sem a ne-cessidade de imobilização absoluta dos cotos da fratura. Estudos recentes apontam que o uso de miniplacas proporcionam estabilidade relativa, ou seja, não há imo-bilização absoluta. A técnica tornou-se popular entre os cirurgiões por se mostrar segura, eficaz e menos invasiva, quando bem indicada. É possível concluir que não há necessidade de o cirurgião sempre optar por um único meio de fixação nos casos de fratura em ângulo mandibular. O melhor meio de fixação neste tipo de fratura deve ser escolhido de acordo com cada caso clínico, podendo ser rígido ou semirrígido, com acesso intraoral ou extraoral. O presente trabalho objetiva reali-zar um levantamento bibliográfico a respeito dos meios de fixação mais utilizados por cirurgiões especialistas no tratamento de fratura no ângulo mandibular em traumas de face, elegendo a técnica ideal para cada caso.
Perda de eficiência na destilaria
Authors: Bonatto Cássia Beatriz , Rego Paulo de Tarso Fernandes Ramos do
Published: July 2023

O Brasil é um dos maiores produtores de cana-de-açúcar, e já produz quase um quarto do etanol gerado no mundo. Para isso, o setor sucroalcooleiro vem crescendo e se modernizando, desde a lavoura de cana-de-açúcar até a indústria para obter ganhos de eficiência e produtividade na produção de açúcar, etanol e energia. Porém, há interferências que geram uma perda de eficiência na etapa de destilação das empresas deste setor. Neste presente estudo, buscou-se entender a perda de eficiência na destilaria de uma empresa de grande porte, causada pela oscilação do vapor vegetal nas colunas de destilação, utilizando ferramentas da qualidade como Diagrama de Pareto para encontrar a principal causa e Diagrama de Ishikawa, analisando todos os fatores que envolvem o processo, a fim de identificar quais têm maior impacto no processo de obtenção do etanol, e propor sugestões para mitigá-los ou até mesmo eliminá-los.
Translation of Cultural Words in Folk Tale “The Origin of the Word Babah” on the Google Translate Service
Authors: Siddiq Mohammad , Nur Ali Ahmad Juma Khatib
Published: July 2023

Background: Folk tale contains words that are bound to a certain cultural context. Globalization and technological developments have made wider access to the folk tales. Google Translate is a translation service that can help translate folk tales with a wide range of users.

Purpose: The focus of this research is limited to how the Google Translate service translates the cultural words in the folk tale of The Origin of the Word Babah.

Design and methods: This research method is descriptive qualitative with research data on the cultural words in the folk tale The Origins of the word Babah which is published by the Ministry of Education and Culture in 1978. This study used analysis of translation strategies and Newmark’s Cultural Words categories as referred classification.

Results: The result of the study shows that the 10 (ten) research data are all in the category of social customs. The translation strategies used are Loan with 5 (five) data and Literal Translation with 5 (five) data. This research shows that Google Translate has not been able to detect cultural contexts, hence it is not accurate in translating cultural addresses and special terms.
ALOE BARBADENSIS MILLER: A COMPREHENSIVE REVIEW
Authors: M. Saleem
Published: July 2023

At present food, nutraceuticals, and pharmaceutical industries desperately searching for new natural compounds with interesting therapeutic potentials from numerous sources. However, there are lots of plants having pharmaceutical benefits but Aloe vera is probably the most applied medicinal plant worldwide since biblical times. Aloe vera is a perennial succulent plant known as the “miracle plant” belonging to the family Liliaceae, commonly known as ghee kwar. It is the most extensively used variety in commercial products because of its therapeutic properties. Aloe vera informed to be contained as much as 75 nutrients, with 200 active components including lignin, anthraquinones, sugar, minerals, saponins, enzymes, vitamins, amino acids, and salicylic acid. Biologically active compounds extracted from aloe vera had been reported to possess several pharmacologic characteristics, specifically to promote healing of the wound, burn, and frostbite, along with antioxidant, laxative, anti-inflammatory, antifungal, antiviral, antibacterial, antitumor, hypoglycemic, gastroprotective antitumor properties. However, on the other side isolated bioactive components such as anthraquinones, phytosterols and saponins are extensively using in nutraceuticals and pharmaceutical products to cure many health ailments. Antioxidant activity is possessed by anthraquinones that are involved in free radical scavenging activity during the inflammatory response and prevent cell necrosis.
1 - Domination and Resistance: Epidemic and Exile in the German Togoland Colony
Authors: Dennis Laumann
Published: July 2023

En 1914, le Roi Dagadu III de Kpandu fut forcé à l’exil par le régime colonial vers la colonie allemande du Togo. Le bannissement du roi pouvait être considéré comme le point culminant d’une série de frictions entre sa cour royale et l’administration coloniale allemande. A l’origine de ce conflit sont les soupçons que les Allemands nourrissaient envers Dagadu qui à leurs yeux demeurait trop amical avec ses anciens alliés britanniques de la Côte d’Or voisine. Cependant, des tensions firent surface au début d’une épidémie à Kpandu. La première charge contre Dagadu était qu’il encourageait la résistance contre une campagne de vaccination allemande dont le but était de freiner la propagation de la maladie du sommeil. Du point de vue du peuple de Kpandu, cette campagne de de vaccination était la cause de l’augmentation des décés dans leur ville alors que le coupable était la méningite. Cette histoire fournit fournit l’opportunité d’explorer comment la domination et la résistance en Afrique coloniale étaient interprétées dans l’arène de la médecine. Tandis que les allemands croyaient que leur connaissance de la santé était « rationnelle » et « scientifique », le peuple de Kpandu voyait leurs colonisateurs comme des tyrans ignorants qui faisaient preuve d’un manque de compréhension totale de la médecine locale. Basé sur l’histoire orale du Ghana et sur les archives coloniales allemandes, cet article prend en compte les notions contradictoires de santé et maladie et les espaces de souveraineté contestées dans l’état colonial.vo
8 - The Western Super-Powers and the Liberation Struggle in Africa: The Politics of Imperialism, Domination and Resistance, 1948-1980s
Authors: Sifiso Mxolisi Ndlovu
Published: July 2023

Controlling South Africa during the Cold War era was geostrategic to the West- ern super powers because of its 1,900-mile coastline with harbours at Durban, East London, Port Elizabeth, Cape Town and Walvis Bay (a seaport in the then South West Africa, now Namibia). Being the southernmost country on the Af- rican continent, South Africa abuts on both the Indian and the Atlantic Oceans and its fascist leaders vociferously pledged to ‘defend the free world from the communist threat’ during the Cold War era. Thus, apartheid South Africa played a vital role in the global strategy of imperialism led by Western super powers such as the United States of America and United Kingdom to make the Indian Ocean area a region for their dominance and total control. South Africa was thus regarded as a ‘second Gibraltar’ or ‘gatekeeper’ to the Indian and Atlantic Oceans. This article is about imperial interventions in the African continent spearheaded by Western super powers, and the pivotal role of apartheid South Africa in this regard. It also discusses the actions of African countries whose leaders acted in solidarity with the apartheid regime which had divisive for- eign policy. But those African leaders who acted in solidarity with the racist South African government represented a minority group vigorously opposed by a majority of Organisation of African Unity member states and the African National Congress (ANC).
9 - History and Literature/Domination and Resistance: Re-Reading the British-Sudan
Authors: Afis Ayinde Oladosu
Published: July 2023

This article is hinged on the assumption that the history, and indeed the historiography, of the violent domination of Africa in the late nineteenth and early twentieth century has been written from and therefore could be situated, tentatively, in-between two discordant perspectives: that of the perpetrator and the victim. Whereas it is true that these histories, particularly those of North African States (Egypt and Sudan) have largely been preserved in, and are ac- cessible both in English and Arabic, recent findings have shown that there still exist a third and an un-explored perspective – the experiential-literary-histori- cal. In trying to explore the latter – that in which the Sudanese writer, Muhammad Miftâh al-Faytûrî attempts not only to ‘tell’ but also ‘show’ how and why the themes of domination and resistance in African history should be reread – this study relies on a combination of Western, Eastern and Afro-Ara- bic historical-theoretical styles, including those of al-Jabartî, Ibn Khaldûn, Ali Mazrui, Friedrich Nietzsche and Nawal Saadawi. The article subsequently finds the following questions highly imperative: Exactly how many histories of the domination of and resistance to oppression in Africa are in existence? In other words, what is the difference between Afranj, Africanist and African histories of domination and resistance? What exactly is the philosophy upon which the ‘perpetrator’ premises his ‘history’ of Africa and how is his perspective sub- verted by that of the ‘victim’? How might the attempt to re-read the history of domination and resistance in Africa benefit from the methods and insights of literary writers and critics? How has the literature of the colonial era func- tioned in writing/telling the hi/story behind the hi/story, and in filling the gaps in Africa’s memory and dignity?
10 - L’artisanat africain entre domination et résistance de la période coloniale à nos jours : le cas de la ville de Maroua au Nord du Cameroun
Authors: François Wassouni
Published: July 2023

Cette réflexion a pour ambition de lire l’histoire de la domination et de la résistance en Afrique à travers les arts et spécifiquement de l’artisanat. La réflexion a été axée sur le Cameroun et spécifiquement sur la ville de Maroua, chef-lieu de la province de l’Extrême-Nord du Cameroun. Ainsi, les filières artisanales mises en place dans cette cité au XIXe siècle par les Kanouri et Haoussa ont subi des influences multiples, de la période coloniale française jusqu’à nos jours. La politique coloniale d’appui à l’artisanat développée par les Français, l’ouverture de la région du Nord-Cameroun au tourisme dans les années 1970 et l’avènement des organisations non gouvernementales qui tra- vaillent dans la promotion de l’artisanat, sont autant de facteurs qui ont changé la physionomie de l’artisanat de Maroua tant du point de vue techni- que, organisationnel que commercial. Face à tous ces éléments analysés sous forme de domination, les artisans de Maroua n’ont pas manqué de riposter par des manières diverses qui témoignent leur résistance aux impositions, laquelle résistance a permis de sauvegarder ces savoir-faire locaux qui consti- tuent un pan important de l’histoire du Cameroun et de l’Afrique tout entière.
12 - De la résistance congolaise à la pénétration monétaire européenne (1878-1930) : une véritable guerre des monnaies
Authors: Guillaume Nkongolo Funkwa
Published: July 2023

Dans un pays dépendant, le contrôle du pouvoir étranger dominant sur le pouvoir local peut passer, ou passe souvent, par le contrôle de sa monnaie. L’article rend compte de cette réalité historique en s’appuyant sur le cas de la République Démocratique du Congo. En effet, il démontre comment, entre 1878 et 1930, le Roi des Belges Léopold II, ses envoyés et puis, le gouvernement colonial belge qui l’a succédé, ont livré bataille à coût d’ordonnances, d’arrêtés, des instructions et des menaces pour prendre contrôle du commerce congolais par l’entremise du contrôle de la circulation monétaire. Création d’une nouvelle unité monétaire (Franc du temps léopoldien), adoption à titre transitoire de l’une des unités de compte traditionnelle dites monnaies-marchandises (Mitako), démonétisation de cette dernière et remplacement par le numéraire (Franc congolais du temps colonial), interdiction de l’unité de compte traditionnelle qualifié de troc, etc ; tous les coups étaient permis. L’article démontre d’autre part, comment les Congolais ont entrepris de résister ou de contourner ces mesures, faisant persister la circulation de leurs monnaies traditionnelles. C’est la victoire finale dans cette guerre des monnaies qui a permis à la Belgique d’asseoir finalement son emprise totale sur l’économie congolaise.
7 - From the Hub of Lagos: Horizontal Integration for the Southwest Region of Nigeria, a Developmental Imperative
Authors: Kenneth Chukwuemeka Nwoko  , Omon Merry Osiki
Published: July 2023

In Nigeria, the experiment at federalism has demonstrated that no meaningful development could be achieved with the present structure of economically and politically weak federating units and a dominating strong centre. The imperative for economic development, therefore, calls for the strengthening of the federating state units. This article investigates the nexus between horizontal integration of the southwest states of Nigeria into a regional bloc within the Nigerian state and the socio-economic development of the region, in relation to the long-term economic development plan of Nigeria. It argues that this horizontal integration is the major catalyst necessary for the attainment of the vision 20:2020 goal of the country. The success of this integration in the southwest would serve as a model for the other regions of the country. This study is an attempt to encourage regional integration and from it regional planning as a critical element of the new economic development strategies of the federating state units in Nigeria in order to provide the spatial development framework for other strategies to succeed.
4 - Le squelette fragile du pouvoir colonial : travail forcé et réseau routier en Basse- Casamance dans l’entre-deux-guerres
Authors: Romain Tiquet
Published: July 2023

Cet article analyse la mise en place locale d’une forme de travail forcé au Sénégal pendant l’entre-deux-guerres : les prestations pour la construction du réseau routier. En prenant l’exemple de la construction de la route Tobor-Ziguinchor en Casamance par des travailleurs forcés prestataires, l’objectif est de montrer comment certaines contingences locales ont influé sur le déroulé des travaux, rendant inapplicables localement des réglementations générales dictées à l’échelle du territoire ou de la fédération. Ainsi, penser les formes de mobilisation forcée de la main-d’oeuvre permet de réfléchir à une nouvelle géographie du travail rompant avec la tendance « dakarocentrée » de l’historiographie classique, qui envisage trop souvent le territoire du Sénégal dans une globalité fictive. Par ailleurs, les populations soumises au travail forcé sur les chantiers routiers sont loin de rester des acteurs passifs de ce système. Elles ont réagi de manière multiple et d versifiée, réussissant à mettre en échec un système arbitraire en son essence.
Afrika Zamani: n°26, 2018 - Full Issue
Authors: Journal System
Published: July 2023

Contents

Conscientious Achievements of the Dangme before the Atlantic Contact: Insights from Archaeological and Ethnohistorical Investigations at Sega and Kpone, Greater Accra Region, Ghana

Fritz Biveridge .......................................................... 1

Quand la reine-mère Dokuwa libère l’Akyem Abuakwa de ladomination Ashanti

Kouamé René Allou .......................................................................25

Recruitment, Resistance and Memories of the First World War among the Terik of Kenya 

Eliud Biegon .................................................................................33

Parcours de la première génération de leaders politiques en Casamance : affirmation identitaire et luttes politiques au Fuladu (1946-1958) 

Mouhamadou Moustapha Sow .................................................................................59

Youth Activism and Ethnic Violence in Nigeria: From Decolonisation to the Nigeria-Biafra War 

Gloria Chuku ..............................................................................................77

Operation Vijiji and its Aftermath: Land Nationalisation, Villagisation and Disputes in Mbulu District, North-Western Tanzania, 1961–2006 

Juma Marmo Paresso .............................................................................109

Le minbar de la dispute ou l’affaire de la « grande mosquée » de Bakel (1995-1996) 

Saliou dit Baba Diallo ........................................................................................ 133
4 - Quand Abidjan était la plaque tournante de l’immigration clandestine africaine vers l’Europe (1960–1975)
Authors: Chikouna Cisse  , Alassane Diabaté
Published: July 2023

Dans cet article, nous tentons d’éprouver la méthode historique dite régressive si chère à Marc Bloch. Elle consiste à appréhender le passé à partir des évolutions et des dynamiques du temps présent. Si l’immigration irrégulière africaine vers l’Europe cristallise de nos jours l’intérêt à l’échelle du globe, c’est en raison de la charge émotionnelle suscitée par les milliers de morts africains en Méditerranée et ailleurs. Nous nous proposons cependant de dépasser cette actualité immédiate pour braquer le projecteur sur l’historicité du phénomène à partir de la Côte d’Ivoire entre les années 1960 et 1975. Le raisonnement historique vise ainsi un double objectif : montrer la centralité de la Côte d’Ivoire dans les mobilités africaines post-coloniales selon des trajectoires et des logiques en rupture avec celles de la période coloniale ; souligner ensuite l’ancienneté du phénomène de la migration irrégulière africaine vers l’Europe, lorsqu’au cours des deux décennies post-indépendance, Abidjan, la capitale ivoirienne, en était l’une des plaques tournantes.
Accrual Accounting: Change And Managing Change
Authors: Saleh Zakiah , Isa Che Ruhana , Abu Hasan Haslida
Published: July 2023

The Malaysian government has decided to adopt accrual accounting to enhance financial accountability and to have a better asset-liability management. Based on experiences of other countries such as Australia and New Zealand, the change process has to be properly man- aged to ensure successful implementation of the new accounting system. Employees’ com- mitment to change has been identified as a critical factor in organisational change. Commit- ment to change model as proposed by Herscovitch and Meyer consists of three components: affective (want to change), normative (ought to change) and continuance (have to change). Hence it is very important for public sector organisations to identify and manage organisa- tional and individual factors influencing commitment to change. The literature has identified factors including organisational support (ICT and human resource), top management support or leadership, communication channel and flow, attitude towards change, employee participa- tion or involvement, are pivotal to successful implementation of accrual accounting. Thus, a study will be conducted to investigate whether the Malaysian government is ready to embrace the change or otherwise.
Strategi Pemasaran Untuk Meningkatkan Pejualan Produk Pada PT. Cipta Niaga Semesta Palembang
Authors: Rusdianto Rusdianto , Subiyanto Subiyanto
Published: July 2023

Tujuan penelitian ini adalah untuk mengetahui bagaimana strategi pemasaran pada PT. Cipta Niaga semesta Palembang dengan menggunakan bauran pemasaran atau marketing mix. Data yang digunakan adalah data sekunder dari tahun 2016-2020,  hasil penelitian ditemukan beberapa strategi pemasaran di PT. Cipta Niaga semesta Palembang yaitu strategi pemasaran dibidang promosi. Pelaksanaan periklanan yaitu menggunakan iklan di televisi, youtube, dan bagi-bagi brosur, pelaksanaan personal selling yaitu dengan cara menawarkan produk ke pasar-pasar tradisional, toko-toko, dan outlet-outlet, pelaksanaan promosi penjualan yaitu dengan cara SPG/B menjual ke warung kecil, warung kopi dan masyarakat setempat serta membawa hadiah, pelaksanaan publikasi yakni menjadi sponsor dalam acara-acara tertentu dan pelaksanaan hubungan masyarakat yakni dengan cara melakukan sampling. Strategi promosi yang dilakukan PT Cipta Niaga semesta Palembang sudah lumayan efektif yakni menerapkan strategi personal selling, periklanan, publisitas, hubungan masyarakat, dan juga promosi penjualan. Hanya saja tidak semua strategi promosi berjalan dengan lancar seperti personal selling, dan promosi penjualan. Hal-hal tersebut berdampak langsung terhadap penjualan. Untuk itu penulis memberi saran perusahaan harus lebih memperhatikan alat untuk meningkatkan  penjualan maka pelaksanaan personal selling sebaiknya para tenaga kerja atau sales diberi training atau latihan khusus yang terprogram, dan pada pelaksanaan promosi penjualan perusahaan hendaknya mulai mencari cara-cara baru yang lebih mudah dan efektif dalam membujuk calon pelanggan serta ditingkatkan dan diperpanjang lagi masa periode pemberian hadiah.
Review: Pengembangan Branding Bangkalan Sebagai Kota dengan Kultur Islami yang “Sustainable”
Authors: Wicaksono Dian , Dianfitria Mira , Pradana Andang
Published: July 2023

Munculnya pandemi COVID-19 di awal tahun 2020 telah memberikan tantangan berat bagi Kabupaten Bangkalan dalam mengakselerasi pertumbuhan perekonomian. Dalam menghadapi momentum- momentum pada tahun 2020 – 2030, maka Kabupaten Bangkalan membutuhkan Strategic Roadmap 2030 sebagai acuan arah pembangunan dan memperkuat persepsi stakeholder terhadap brand Kabupaten Bangkalan.  Tahapan pembangunan tersebut yaitu (1) Mengembangkan Pariwisata Halal yang terintegrasi dengan memanfaatkan Entrepreneurial Mindset, (2) Pengembangan Ekosistem Industri Halal Untuk Pengembangan Ekonomi, (3) Mewujudkan Kota Islam yang Berkelanjutan. Pada fase pembangunan pertama mengusung tema target pembangunan yaitu “Integrated Halal Tourism with Entrepreneurial Spirit”. Fase pertama ini merupakan fase pemulihan (recovery) perekonomian akibat situasi pandemi. Pengembangan potensi wisata dapat menjadi alternatif terbaik untuk menjadi quick win pengembangan Kabupaten Bangkalan dengan memanfaatkan sumber daya lokal yang sudah tersedia melalui berbagai kolaborasi. Pada konsep Halal Entrepreneurial Mindset, pariwisata halal yang terintegrasi di Kabupaten Bangkalan dapat dibangun melalui 3 kunci utama: (1) Memanfaatkan peluang dalam menarik wisatawan, (2) Berani mengambil risiko untuk mengembangkan produk pariwisata, dan (3) Kolaborasi dalam meningkatkan brand pariwisata Bangkalan.
Relevance and Responsiveness of the Bachelor of Science in Customs Administration Program as Assessed by Stakeholders
Authors: Balajadia Ruth
Published: July 2023

Responsiveness/relevance is perceived as the starting point for determining what constitutes a quality education. Since development is necessary, systems that support development, like education and training systems, must be responsive. This study is focused on the relevance and responsiveness of the Bachelor of Science in Customs Administration (BSCA) program and to determine whether the initiatives currently practiced by the college to make the program relevant/responsive are effective. John B. Lacson Colleges Foundation-Bacolod is a higher education institution that offers a BSCA program and is the only one in Negros Occidental. However, despite the very satisfactory results in the board examination in the past years and the high demand for employment in the import and export industry, only a few are enrolled in the program. Hence, the conduct of this study is to explore opportunities to improve enrolment.  This descriptive study used the survey method to gather the data needed, with Mean and Standard Deviation as statistical tools. A discussion with representative stakeholders was made on the initiatives and strategies practiced by the college to calibrate the program. The respondents were 24 BSCA students, 53 alumni, and 22 industry representatives. The findings showed that the BSCA program is relevant and responsive to a very great extent, as assessed by the alumni and students, and relevant/responsive to a great extent by the industry.
Extent of Forensic Practices of Police Investigators: A Basis for Enhancement Plan
Authors: Quiape Japhet , Painaga Ermee Joy
Published: July 2023

In criminal investigations, the Directorate for Investigation and Detective Management – Police investigators are required by Philippine National Police orders to conduct forensic science-based crime scene investigations. In order to ensure that every government employee adheres to the accepted belief that public office is a public trust, it is challenging to assess the work of police detectives performing crime scene investigations using forensic technology. This essential value of forensic science in police investigations is undeniable. This study discusses the scope of police forensic methods in ballistics, photography, and dactyloscopy, specifically in the Province of Antique. These issues regarding the scope of practices in conducting investigations and forensic examinations are expressed via a survey questionnaire and a series of statistical tests. In addition, the report outlines the difficulties experienced by these Philippine National Police investigators. The results of the study found that police investigators had a high level of forensic experience with ballistics and photography. Further, results revealed low level of forensic experience with dactyloscopy.. Therefore, Police investigators, among many solutions, may consider the following to be of great help: 1-attending relevant seminars and trainings involving dactyloscopy, and 2- specifying budget allocation for lacking equipment.
ENDIVIDAMENTO DOS MUNICIPIOS DO ESTADO DO RIO DE JANEIRO: UMA ANÁLISE DOS EFEITOS DA LEI DE RESPONSABILIDADE FISCAL
Authors: De Souza Ribeiro Edvander , Carvalho Andrade Maria Elisabeth Moreira , Olímpia Neves Mamede Maestri Claudia , Lucena de Oliveira Rodrigo
Published: July 2023

A Lei de Responsabilidade Fiscal (LRF) tem o objetivo de estabelecer limites para a administração de recursos e gestão de receitas e despesas da União, dos estados e municípios, sendo considerada um elemento de suma importância para a busca de uma administração economicamente sustentável dos entes públicos. O objetivo geral deste estudo é investigar as variáveis financeiras que afetaram o nível de endividamento dos municípios do Estado do Rio de Janeiro no período de 2005 a 2019, este estado foi escolhido devido ser o primeiro a decretar estado de calamidade financeira em junho de 2016. Os efeitos da LRF sobre o endividamento público municipal foram analisados com base em indicadores de gestão financeira descritos por Macedo e Corbari (2009). Os resultados obtidos demonstraram que há uma correlação positiva entre o endividamento dos municípios e as variáveis de Endividamento Defasado, Estrutura de Capital e Despesa de Pessoal, embora esta última não tenha apresentado variação significativa ao longo do período analisado. Em relação às variáveis de Liquidez, Grau de Dependência e Despesa com Investimento, foi observado um coeficiente negativo. Dessa forma é possível concluir que a aprovação da LRF, embora seja um verdadeiro marco para a Administração Pública brasileira, não é suficiente isoladamente para solucionar o endividamento dos municípios do estado analisado, sendo necessário a criação de outras estratégias que fortaleça a cultura de valorização do equilibro fiscal de forma a priorizar a redução do endividamento público.
Characteristics and clinical features of cauda equina syndrome: insights from a study on 256 patients
Authors: Zeb Junaid , Zaib Jehan , Khan Arshad , Farid Mehreen , Ambreen Seemab , Shah Syed Hussaini
Published: July 2023

Objective: To determine the frequency, clinical presentation, and etiological factors of cauda equina syndrome (CES). Materials and method: This retrospective study was done on 256 participants, and aimed to analyze the frequency and patterns of clinical presentation in suspected cases of CES. The inclusion criteria included participants aged 18 or older with medical records available for review and having red-flagged symptoms for CES. The study collected information on various factors such as age, gender, confirmation of CES on MRI, neurological deficits, etiological factors, duration of symptoms, and more. The data collected was analyzed using descriptive statistics and logistic regression to identify significant variables between MRI-proven CES and suspected CES. Results: The mean age was 58.05 ± 19.26 years, with 151 females (58.98%) and 105 males (41.02%). The majority (50.78%) had a neurological deficit, while other symptoms included difficulty initiating micturition or impaired sensation of urinary flow (17.58%), loss of sensation of rectal fullness (3.12%), urinary or faecal incontinence (35.16%), bilateral sciatica (21.88%), neurological symptoms in the lower limbs (25.00%), anaesthesia or any leg weakness (24.22%), and bilateral sciatica as the predominant symptom (21.88%). Symptoms were chronic in 47.27% and acute in 21.88%. The odds of MRI-proven CES increase by 3% per year of age. Neurological deficit was strongly associated with MRI-proven CES (OR = 14.97), while loss of sensation of rectal fullness increased the odds by 10-fold (OR = 10.62). Conclusion: CES can present with various symptoms, including the bilateral neurological deficit, urinary and faecal incontinence, and bilateral sciatica, with age, severe bilateral neurological deficit, and loss of sensation of rectal fullness being associated with MRI-proven CES. Early diagnosis and treatment are crucial for better outcomes.
Old Irish Námae 'Enemy' and the Celtic NT-Stems
Authors: Joseph Lionel
Published: July 2023

In this study, I will present as complete a collection as I can of Celtic nt-stems in order to answer the general question what types of nt-stems occur in Celtic, and specifically to use that collection to determine the most probable pre-form of Old Irish námae ‘enemy’ and its Gaulish cognates, about which there has been a lively discussion ever since 1923. I will also discuss in detail the system of adjectives and abstracts of which Old Irish lethan ‘broad’ : lethet ‘breadth’ is representative.
Participación de los públicos, inclusión social, innovación y Gobernanza de los Centros de Ciencia en Colombia
Authors: Blanco Valbuena Carlos Emilio
Published: July 2023

El objetivo de este artículo es evaluar las prácticas tácitas y explícitasrelacionadas con la gobernanza de los Centros de Ciencia de Colombia(ccc) desde la participación de los públicos, la inclusión social, y lainnovación, con el fin de proponer mecanismos y estrategias quefortalezcan las capacidades de los diferentes actores, para tener unaciudadanía cada vez más participativa, científica y democrática. Parala identificación de la muestra teórica nos basamos en los aportes deStrauss y Corbin (1998). En una muestra teórica, los casos se eligenpara rellenar categorías teóricas y para proporcionar ejemplos desituaciones extremas y tipos polares (Eisenhardt, 1989). Se llevarona cabo entrevistas presenciales hechas en profundidad mediante uncuestionario de preguntas específicas seleccionadas en función delas variables. Los datos fueron analizados con técnicas destinadas al desarrollo de la teoría basada en los aportes de (Strauss y Corbin,1998), conceptualizando y reduciendo los resultados de las entrevistasen categorías comunes, y encontrando relaciones a través de ellas.Los resultados de este estudio están en concordancia con Bandelli etal. (2009), Freeman (2010) y Quick y Bryson (2016), cuando afirmanque la participación implica la contribución directa o indirecta hechapor personas o grupos con capacidad para influir en el desarrollo deproyectos y programas. Concluimos que los ciudadanos no participande la toma de decisiones con respecto a la gestión, y ello es debidofundamentalmente a que las estructuras internas concebidas sonrígidas y están administradas por los miembros de la junta y losdirectivos. El artículo es original producto de la investigación.
La nueva política migratoria marroquí ante retos de transnacionalismo y codesarrollo
Authors: Aboussi Mourad
Published: July 2023

Marruecos está promoviendo durante la última década una nueva política migratoria basada en la inclusión de sus emigrantes en las instituciones del país estableciendo las bases de su participación en el proceso democrático. Las reivindicaciones de la comunidad marroquí en el extranjero han entrado en la agenda política del país en los cinco últimos años y han sido atendidas mediante varias iniciativas estatales, teniendo en cuenta las prácticas de transnacionalismo, los efectos de la crisis y las posibilidades de codesarrollo. Este artículo relata los cambios que han sucedido, analiza la pertinencia y eficacia de las iniciativas emprendidas y propone una reflexión sobre la coherencia de la infraestructura institucional existente AbstractMorocco is promoting a new migratory policy withthe challenge of including its emigrants in the country's institutions and of establishing the basis of their participation in the democratic process. In the last five years, the demands made by the Moroccan community abroad in defense of their rights have made their way onto the country's political agenda and have been addressed by means of various state initiatives, considering the transnational practices, the effects of economic crisis and the possibilities of codevelopment.This article calls into question the relevance and effectiveness of the public policies aimed at Moroccan emigrants and the coherence of the institutional infrastructure in place.
HIỆN TRẠNG KHAI THÁC NGUỒN LỢI THỦY HẢI SẢN Ở KHU DỰ TRỮ SINH QUYỂN THẾ GIỚI CÙ LAO CHÀM-HỘI AN
Authors: Long Nguyen Van , Dat Mai Xuan
Published: July 2023

Đánh giá hiện trạng khai thác nguồn lợi thủy hải sản ở Khu dự trữ sinh quyển thế giới Cù Lao Chàm - Hội An được thực hiện thông qua 11 cuộc tham vấn cộng đồng tại 11 xã/phường có hoạt động khai thác liên quan vào tháng 11–12/2015 kết hợp với phân tích 150 mẫu nguồn lợi từ các loại nghề khai thác chính và các điểm lên cá vào mùa mưa (tháng 11/2015) và mùa khô (tháng 6/2016). Kết quả nghiên cứu cho thấy hoạt động khai thác thủy hải sản trong Khu dự trữ sinh quyển thế giới khá đa dạng gồm 29 loại nghề với trên 208 loài được khai thác, trong đó 36 nhóm đối tượng được xem là nguồn lợi quan trọng. Tổng sản lượng khai thác thủy hải sản hàng năm ước đạt 12.796,4 tấn thương phẩm cùng với 7.020.400 con giống (tương đương 780 kg) cá dìa công và 385.400 con giống (cá hồng bạc, cá mú mè, cá mú điểm gai, cá nâu và cua xanh) được khai thác trong năm 2015 với doanh thu khoảng 210 tỷ đồng, trong đó cá là thành phần chiếm ưu thế. Vùng nước ngoài rạn san hô và cửa sông chiếm sản lượng cao gấp 10,8 lần so với vùng hạ lưu sông Thu Bồn và gấp 22,2 lần so với rạn san hô. Khu vực phân bố tập trung của hầu hết các loại con giống là các bãi bồi xung quanh Gò Hí - Thôn 4 nơi có sự hiện diện của cỏ biển và dừa nước thuộc khu vực rừng dừa bảy mẫu xã Cẩm Thanh.
The Effectiveness of Roselle Kombucha Tea in Increasing Haemoglobin Levels Mice (Mus imusculus) With Anaemic
Authors: Wijayanti Tut Rayani Aksohini , Retnaningsih Reny
Published: July 2023

Anaemic caused by Iron deficiency can be affected by a lack of vitamin C. Vitamin C can reduce ferrous iron (Fe3+) to ferrous (Fe2+) in the small intestine so that it is easily absorbed. Kombucha tea is a functional drink known to the public for a long time and provides health benefits. The study aimed to determine the effectiveness of kombucha rosella tea against increasing haemoglobin levels in mice (Mus musculus) anaemic. The type of research is true experimental with a pre-post test randomized control group design. Treatment with four treatments and three repetitions. The sample from this study was mice (Mus musculus), female, 2-3 months, weighing 20-25 as many as 24 heads. Administration of kombucha rosella tea in anaemic mice at different doses (0.36 ml / 20 g BB, 0.55 ml / 20 g BB and 0.73 ml / 20 g BB) for 14 days. Giving kombucha rosella tea can increase haemoglobin levels in the blood of mice (Mus musculus) anaemic. The optimal dose of use of kombucha rosella tea against an increase in haemoglobin levels in the blood of anaemic mice is 0.73 ml / 20 g BB. It is necessary to conduct further research on using kombucha rosella tea in human subjects to obtain further substantiation of the benefits of kombucha rosella tea as a treatment therapy.
Molecular study of the relationship of gene expression of some genes with the temperature variation of bacterial growth
Authors: Al-Fhdawi Ahmed Attalla Hasan , Rabee Adel Meshaan
Published: July 2023

Pseudomonas aeruginosa is an opportunistic pathogen responsible for serious infections. At least three different exopolysaccharides, alginate, polysaccharide synthesis locus (Psl), and pellicle exopolysaccharide (Pel) make up the biofilm matrix in P. aeruginosa . The effect of temperature on the biofilm formation and gene expression was examined by microtiter plate and real-time quantitative polymerase chain reaction (qRT-PCR). To be able to determine the effect of temperature on biofilm formation and gene expression of P. aeruginosa, 303 clinical and environmental samples were collected. Pseudomonas aeruginosa was isolated from 61 (20.1%) and 48 (15.8%) of the clinical and environmental samples, respectively. The ability of clinical and environmental P. aeruginosa isolates to develop biofilm was observed in 86.9% and 85.42% of the isolates, respectively, distributed into strong, moderate, and weak biofilm producers. Moreover, gene expression for pslA, pelA and algD genes was estimated for clinical and environmental isolates, the clinical P. aeruginosa isolates showed the highest biofilm production and the highest gene expression of pslA, pelA and algD genes as compared to environmental isolates when temperature changed. In summary, both clinical and environmental isolates formed biofilm and carried psl A, pel A and alg D genes regardless of the intensity of the biofilm. Also, 37°C represented the best temperature for biofilm production.
Editorial introduction for special issue -- Regional Communication Student Colloqium (RCSC) 2022
Authors: A Rahman Nur Atikah , Balaraman Rani Ann
Published: July 2023

In light of equipping ourselves with further perspective on how hybrid communication has made an impact to our communication and media field, the School of Communication, Universiti Sains Malaysia has organized the Regional Communication Student Colloquium (RCSC) 2022 in 20th October 2022, to provide students a platform to exchange their knowledge, experience and perspectives on the pertaining issue. RCSC 2022 aspires to offer a valuable research culture among students, both undergraduates and postgraduates in preparing them to become competent and established scholars. In specific, this colloquium is about “Celebrating Novice Researchers” in fostering students to share their novel ideas and offer opportunities for students to present their research to the communication society, in Malaysia as well as abroad. Particularly, our aim is to foster research culture among students and give them exposure on the research practices among scholars. Hence, this Special Issue presents the core perspectives of hybrid communication and digitally connected world in further sustaining people’s lives. The papers in this Special Issue comprise diverse range of topics, perspectives and research in communication and media that were presented and discoursed by both postgraduate and undergraduate students. In specific, the articles engage readers on issues, impact and challenges that are related to hybrid communication. Dr Nur Atikah A Rahman and Dr Rani Ann Balaraman Advisors of RCSC 2022 Organising Committee School of Communication Universiti Sains Malaysia
Naxitamab-combination therapy for the treatment of patients with refractory and/or relapsed high-risk neuroblastoma
Authors: Trovillion Erin , Michael Meghan , Brown Lauren , Phillips Katlin , Oesterheld Javier , Sholler Giselle Saulnier
Published: July 2023

Approved treatments for patients with refractory and/or relapsed (R/R)
high-risk (HR) neuroblastoma are limited, and there is a high unmet need
for new treatment combinations. The Atrium Health Levine Children’s
Hospital pediatric oncology solid tumor team has successfully treated
ten patients with R/R HR neuroblastoma with the anti-disialoganglioside
2 antibody naxitamab with granulocyte-macrophage colony-stimulating
factor (GM-CSF), and four patients with naxitamab and GM-CSF in
combination with cyclophosphamide and topotecan. Antibody therapy with
chemoimmunotherapy was well tolerated in the four heavily pre-treated
patients with R/R HR neuroblastoma who had few treatment options and
overall poor prognosis.
TARIKAN SUPERMARKET TERHADAP PERGERAKAN KENDARAAN
Authors: Artana Made Agus , Ardi Juni
Published: July 2023

Supermarket merupakan salah satu jenis pemanfaatan tata guna lahan yang akan menimbulkan tarikan pergerakan kendaraan. Untuk mengetahui model tarikan kendaraan pada supermarket data yang digunakan meliputi data jumlah pengunjung, jumlah pegawai, luas gedung, luas area parkir, dan jumlah kendaraan. Dua model hasil matematis weekday dan weekend,   yaitu (Y) 5,775 + 41,225 (X3)   pada weekday dengan variabel jumlah pegawai (X3) yang paling berengaruh dengan nilai R2 (R Square) sebesar 0,814 dan (Y) = 276,130 + 1,520 (X4)  pada  weekend  dengan  variabel  jumlah  kendaraan  (X5)  yang  paling berengaruh dengan nilai R2 (R Square) sebesar 0, 941.