bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutrition knowledge and attitude of Babcock University medical and nursing students and Inter-professional collaboration with Dietitians in patient care
Authors: Ani Ime , Adeola Adeola , Ajuzie Nnenna , Sam-Okere Miriam
Published: July 2022

Objective: The study assessed nutrition knowledge and attitude of final year medical and nursing students and inter-professional collaboration with dietitians in the management of patients.
Methodology: This cross-sectional study of all final year medical and nursing and Babcock University students collected quantitative data using a structured questionnaire that contains sections on nutrition instruction hours, knowledge, attitude, and barriers to nutrition. Data obtained was analyzed using the Statistical Package for Social Sciences (SPSS) version 20. Statistics were significant at p<0.05.
Result: A total of 159 students participated in the study, 73 medical students and 86 nursing students. The proportion of those who had good, average, and poor knowledge scores were 50.3%, 39%, and 10.7% respectively. The attitude towards nutrition was positive. There was no significant relationship between nutrition knowledge and nutrition instruction hours during pre-clinical (P=0.368) and clinical years (P=0.245).
Conclusion: Significant proportions of the students had good nutrition knowledge, however, there were gaps in knowledge in clinical nutrition; nutritional management of diabetes, hypertension, and renal diseases, respectively. There was a high positive attitude towards nutrition among the students but nutrition education was not perceived as sufficient to adequately prepare them for nutrition care of patients. Insufficient training for doctors and nurses, lack of confidence in the efficacy of the intervention of dietitians/nutritionists, and Lack of interest from patients to see the dietitian were the prominent barriers to inter-professional collaboration with dietitians/nutritionists.
Pathogenesis of peritoneal drain complications; a case report of evolving adnexal evisceration following difficult retrieval of a retained peritoneal drain
Authors: Imaralu John , Oguntade Funmilayo , Nwankpa Chimaobi , Adelowo Olumuyiwa
Published: July 2022

Background: Intra-peritoneal drainage dates back to the time of Hippocrates when long bone tissue, metal, and glass tubes were employed. The benefit of routine intra-peritoneal drainage however remains debatable in contemporary times. Retained drains may be outward manifestations of more sinister or latent complications and how an entrapped surgical drain is removed, may determine the occurrence of further complications.
Case Presentation: We report here the case of a 32-year-old primipara who had a retained improvised peritoneal drain, which was inserted during the cesarean section for continued oozing of serosanguineous fluid. Omental tissue found at laparoscopy, to have plugged a fenestration in the drain, was promptly relieved. A loop of the Fallopian tube was however later observed trapped in another fenestration and herniating into the stab incision of the drain tube towards the exterior, this was freed with an atraumatic laparoscopic grasper and drain tube retrieval completed under laparoscopic visualization.
Conclusion: Insertion of the peritoneal drain during cesarean section should be carefully considered, when necessary; it should be done with the most appropriate drainage systems. Retrieval of the peritoneal drain is a risk factor for visceral herniation. Entrapped drains should be retrieved, under direct visualization, to prevent iatrogenic injuries.
EKSISTENSI PENDIDIKAN TOLERANSI BERAGAMA BERBASIS LITERASI BUDAYA DAN KEWARGAAN DALAM ERA MEDIA 4.0
Authors: Pertiwi Latif , Kharisma Nanda Veruna Enun
Published: July 2022

This study aims to describe the existence of cultural and civic-based religious tolerance education at SDN 04 Sipkanyin in the media moderation 4.0 era. This research uses a qualitative approach, case study model. The research data collection used observation, interviews, and documentation. The results showed that SDN 04 Sipkanyin has displayed the existence of religious tolerance through learning, school culture, and student self-development by utilizing existing modern technology. Through learning, lesson plan, implementation, assessment, and evaluation are succesfully observed. The academic culture is sensed through installing school’s vision and mission, and discipline. Religious cooperation and guidance are manisfested through democratic culture. Students' self-development is executed through routine extracurricular activities, literacy, religious harmony movies, morning apples, and Monday ceremonies. Spontaneous activities are in form of reprimands, advice, and praise. Exemplary is given through the provision of examples by teachers. Conditioning is by providing infrastructures. Keywords: Religious Tolerance Education; Cultural Literacy and Citizenship; Media Era 4.0
THE POLICY OF ORGANIZATION, THE SPIRIT OF PROGRESSIVISM ISLAM, AND ITS ASSOCIATION WITH SOCIAL WELFARE EDUCATORS
Authors: Karim Abdul , Faiz Aiman , Nur'Aini Nunuy , Rahman Febiyana Yolanda
Published: July 2022

The purpose of this article examines the advantages of understanding the spirit of progressive Islam, compliance with organizational policies related to social welfare. The research is carried out at SDIT Muhammadiyah Cirebon. The subjects of this study were the principal, 15 Educators, and 5 Education Personnel. This research uses qualitative which uses instruments in form of interviews, observations, and documentation, also strengthened quantitatively by questionnaires. The approach used is cultural interpretation. Descriptive statistical analysis is used to describe the general state, and the data obtained from the questionnaire will be analyzed statistically descriptively. The results showed that organizational policies are based on the spirit of progressive Islam, and the policy of SDIT Muhammadiyah’s principal through transforming, habituating, as well as forming values. Another finding is that the educators at SDIT Muhammadiyah are socially and financially prosperous. It can be concluded that education personnel have prospered socially in addition to compliance with the principal’s policies, also because the progressive Islam principles’ understanding.Keywords: Progressive Islam; Organizational Policy; Social Welfare; Muhammadiyah
MENIMBANG ISTIHSAN SEBAGAI DALIL LEGALITAS DALAM MUAMALAH
Authors: Muhajirin Muhajirin
Published: July 2022

The Istihsan method is a legal argument whose existence is not agreed upon by ushul scholars, so the legality of the law born from this method has been debated until now. The research method used is normative juridical, which is literature study. The approach used is by comparing between the opinions of Mutakallimin and Fuqaha. Researchers conclude that The Istihsan actually has a strong foundation from both the Qur'an and al-Hadith. Its existence is an independent syara', that it can be implemented in actual problems, notably in the field of muamalah. The difference of opinion among Ushul scholars about to have Istihsan or not actually goes back to the standard of Urf as one of Istidlal methods. Implementing the method in the field of muamalah (Islamic Economy) can be found within contract of Salam, Istishna' and sale and purchase (Bai' al-Taqsith or Bai' bi Tsaman al-'Ajl). Keywords: istihsan; salam; istshna'; bai' al-taqsith.
The Dynamic Evolution of Solar Wind Streams Following Interchange Reconnection
Authors: Scott Roger B. , Bradshaw Stephen J. , Linton Mark G.
Published: July 2022

Interchange reconnection is thought to play an important role in determining the dynamics and material composition of the slow solar wind that originates from near coronal-hole boundaries. To explore the implications of this process we simulate the dynamic evolution of a solar wind stream along a newly-opened magnetic flux tube. The initial condition is composed of a piecewise continuous dynamic equilibrium in which the regions above and below the reconnection site are extracted from steady-state solutions along open and closed field lines. The initial discontinuity at the reconnection site is highly unstable and evolves as a Riemann problem, decomposing into an outward-propagating shock and inward-propagating rarefaction that eventually develop into a classic N-wave configuration. This configuration ultimately propagates into the heliosphere as a coherent structure and the entire system eventually settles to a quasi-steady wind solution. In addition to simulating the fluid evolution we also calculate the time-dependent non-equilibrium ionization of oxygen in real time in order to construct in situ diagnostics of the conditions near the reconnection site. This idealized description of the plasma dynamics along a newly-opened magnetic field line provides a baseline for predicting and interpreting the implications of interchange reconnection for the slow solar wind. Notably, the density and velocity within the expanding N-wave are generally enhanced over the ambient wind, as is the O7+/O6+ ionization ratio, which exhibits a discontinuity across the reconnection site that is transported by the flow and arrives later than the propagating N-wave.
Curved Jet Motion. I. Orbiting and Precessing Jets
Authors: Fendt Christian , Yardimci Melis
Published: July 2022

Astrophysical jets are often observed as bent or curved structures. We also know that the different jet sources may be binary in nature, which may lead to a regular, periodic motion of the jet nozzle, an orbital motion, or precession. Here we present the results of 2D (M)HD simulations in order to investigate how a precessing or orbiting jet nozzle affects the propagation of a high-speed jet. We have performed a parameter study of systems with different precession angles, different orbital periods or separations, and different magnetic field strengths. We find that these kinds of nozzles lead to curved jet propagation, which is determined by the main parameters that define the jet nozzle. We find C-shaped jets from orbiting nozzles and S-shaped jets from precessing nozzles. Over a long time and long distances, the initially curved jet motion bores a broad channel into the ambient gas that is filled with high-speed jet material whose lateral motion is damped, however. A strong (longitudinal) magnetic field can damp the jet curvature that is enforced by either precession or orbital motion of the jet sources. We have investigated the force balance across the jet and ambient medium and found that the lateral magnetic pressure and gas pressure gradients are almost balanced, but that a lack of gas pressure on the concave side of the curvature is leading to the lateral motion. Magnetic tension does not play a significant role. Our results are obtained in code units, but we provide scaling relations such that our results may be applied to young stars, microquasars, symbiotic stars, or active galactic nuclei.
Toward a Unified Explanation for the Three-part Structure of Solar Coronal Mass Ejections
Authors: Song Hongqiang , Li Leping , Chen Yao
Published: July 2022

Coronal mass ejections (CMEs) are associated with the eruption of magnetic flux ropes (MFRs), which usually appear as hot channels in active regions and coronal cavities in quiet-Sun regions. CMEs often exhibit a classical three-part structure in the lower corona when imaged with white-light coronagraphs, including a bright front, dark cavity, and bright core. For several decades, the bright core and dark cavity have been regarded as the erupted prominence and MFR, respectively. However, recent studies have clearly demonstrated that both the prominence and hot-channel MFR can be observed as the CME core. The current research presents a three-part CME resulting from the eruption of a coronal prominence cavity on 2010 October 7, with observations from two vantage perspectives, i.e., edge-on from the Earth and face-on from the Solar Terrestrial Relations Observatory (STEREO). Our observations illustrate two important results: (1) for the first time, the erupting coronal cavity is recorded as a channel-like structure in the extreme-ultraviolet passband, analogous to the hot-channel morphology, and is dubbed as the warm channel; and (2) both the prominence and warm-channel MFR (coronal cavity) in the extreme-ultraviolet passbands evolve into the CME core in the white-light coronagraphs of STEREO-A. The results suggest that we are working toward a unified explanation for the three-part structure of CMEs, in which both prominences and MFRs (hot or warm channels) are responsible for the bright core.
The Volatile Carbon-to-oxygen Ratio as a Tracer for the Formation Locations of Interstellar Comets
Authors: Seligman Darryl Z. , Rogers Leslie A. , Cabot Samuel H. C. , Noonan John W. , Kareta Theodore , Mandt Kathleen E. , Ciesla Fred , McKay Adam , Feinstein Adina D. , Levine W. Garrett , Bean Jacob L. , Nordlander Thomas , Krumholz Mark R. , Mansfield Megan , Hoover Devin J. , Van Clepper Eric
Published: July 2022

Based on the occurrence rates implied by the discoveries of 1I/‘Oumuamua and 2I/Borisov, the forthcoming Rubin Observatory Legacy Survey of Space and Time (LSST) should detect ≥one interstellar object every year. We advocate for future measurements of the production rates of H2O, CO2, and CO in these objects to estimate their carbon-to-oxygen ratios, which trace formation locations within their original protoplanetary disks. We review similar measurements for solar system comets, which indicate formation interior to the CO snow line. By quantifying the relative processing in the interstellar medium and solar system, we estimate that production rates will not be representative of primordial compositions for the majority of interstellar comets. Preferential desorption of CO and CO2 relative to H2O in the interstellar medium implies that measured C/O ratios represent lower limits on the primordial ratios. Specifically, production rate ratios of Q(CO)/Q(H2O) < 0.2 and Q(CO)/Q(H2O) > 1 likely indicate formation interior and exterior to the CO snow line, respectively. The high C/O ratio of 2I/Borisov implies that it formed exterior to the CO snow line. We provide an overview of the currently operational facilities capable of obtaining these measurements that will constrain the fraction of ejected comets that formed exterior to the CO snow line. This fraction will provide key insights into the efficiency of and mechanisms for cometary ejection in exoplanetary systems.
Stage at Diagnosis and Patient Delay among Breast Cancer Women in Kabul, Afghanistan
Authors: Behrad Mohammad Sayed , Rashed Firoozeddin , Zarabi Attaullah , Saidi Surya
Published: July 2022

Background: Breast cancer is the commonest cause of mortality among women. According to WHO in 2012, about 7400 women died because of cancers in Afghanistan.   Aim: To obtain information about clinical stages of breast cancer of women at the time of diagnosis in Kabul, Afghanistan.   Patient and Method: This was a cross-sectional study of 240 women diagnosed with breast cancer from March 2016 to March 2019. The diagnosis of breast cancer was made by the surgeon on the basis of physical examination and Biopsy/Pathological reports. Clinical staging of the tumor was recorded according to the tumor, nodal, and metastasis (TNM) classification. The gap between knowing the problem and consulting a physician (Patient delay) was categorized: less than 3 months, 3-6 months and more than 6 months. Results: The mean age of patients was 49.31 years (SD ± 11.80) ranging from 18 to 76 years. The Patient delay was more than 6 months (65%). Infiltrating ductal carcinoma was the commonest morphological type (76.7%). Breast cancer in left breast of patients was 52.1%. Stage II was higher in left and stage III in right breast. The majority of patients were in stage II & III at the time of diagnosis. All stages were frequent in fourth decades of age group. The association between the clinical stages of breast cancer at the time of diagnosis, the age and breast R/L involvement of the patients was significant (P<0.001). The association between clinical stage and marital status was not significant (P<0.953). Conclusion: Late referrals, diagnosis delay and advanced stages of breast cancer are still a serious problem in Afghanistan. Cancer in right breast should be given more attention because higher stages of the disease are expected. Awareness and social education is great need.
Age as a Determinant in Selecting Type of Breast Cancer Surgery in Lovely Pink Solo Cancer Community
Authors: Faeni Hanum , Yarso Kristanto Yuli , Wasita Brian , Rahayu Rachmi Fauziah , Suyatmi Suyatmi , Wiyono Nanang , Persik Riza Novierta , Wicaksana Iman Hakim , Azmiardi Akhmad , Ramadhanty Zhafira
Published: July 2022

Breast-Conserving Surgery as a treatment option for older patients with early breast cancerHanum Faeni, MD1., Kristanto Yuli Yarso, MD2., Brian Wasita, MD3., Rachmi Fauziah Rahayu, MD4., Suyatmi Suyatmi, MD5., Nanang Wiyono, MD6., Riza Novierta Persik, MD3., Iman Hakim Wicaksana, MD1., Akhmad Azmiardi, MD7., Zhafira Ramadhanty, MD8.1 Resident of Surgery, Department of Surgery, Universitas Sebelas Maret, Surakarta, Jawa Tengah, Indonesia2 Oncology Surgeon, Department of Surgery, Universitas Sebelas Maret, Surakarta, Jawa Tengah, Indonesia3 Department of Anatomical Pathology, Universitas Sebelas Maret, Surakarta, Jawa Tengah, Indonesia4 Department of Radiology, Universitas Sebelas Maret, Surakarta, Jawa Tengah, Indonesia5 Department of Histology, Universitas Sebelas Maret, Surakarta, Jawa Tengah, Indonesia6 Department of Anatomy, Universitas Sebelas Maret, Surakarta, Jawa Tengah, Indonesia7 Doctoral Program on Public Health, Universitas Sebelas Maret, Surakarta, Jawa Tengah, Indonesia8 Medical Student, Universitas Sebelas Maret, Surakarta, Jawa Tengah, Indonesia
Objective: Breast cancer is one of the most common malignancies in Indonesia. Breast cancer occurs due to rapid and abnormal cell growth due to infiltration of lymphatic tissue and blood vessels. For this reason, surgery is vital to use as a treatment for breast cancer at an early stage. There are two surgical methods: Breast-Conserving Surgery (BCS) and mastectomy. In this regard, several factors have been studied to influence patients in choosing BCS or mastectomy. Looking at the age factor, the results varied and differed significantly throughout the study.Method: This analytical study used a retrospective cross-sectional approach. The research subjects were patients with breast cancer who were the Lovely Pink community members in Surakarta City, Central Java. Subjects were selected by simple random sampling with inclusion criteria consisting of female patients aged 20 to 80 years, being diagnosed with stage 1 and 2 breast cancer, and having received surgery employing BCS or mastectomy techniques.Result: This study was conducted on 218 breast cancer patients who had undergone mastectomy or BCS in Surakarta City, Central Java. It was found that 104 patients were < 50 years old and 114 patients > 50 years old. 76 patients (34.9%) and 142 patients (65.1%) had a total income of more or less than Rp2.5 million/month. As many as 155 patients (71.1%) and 63 patients (28.9%) had no history of disease. Based on the type of surgery performed, 141 people (64.7%) underwent mastectomy, and 77 people (35.3%) underwent BCS.Conclusion: It can be concluded that patients prefer to undergo mastectomy with significant results at the age of under and above 50 years supported by income, medical history, and work history.Keywords: breast-conserving surgery, mastectomy, age
The Role of Perioperative Levosimendan in Patients with Reduced Ejection Fraction undergoing Cardiac surgery in Reducing Post-operative Hemodynamic Support
Authors: Fakher Mohamed , Aboelghet Mohamed , Moharam Ayman , Khaled Mahmoud , Abdelaziz Ahmed
Published: July 2022

BACKGROUND: Acute perioperative left ventricular dysfunction is a major complication affecting patients subjected to cardiac surgery and is associated with increased mortality. Levosimendan as a “calcium sensitizers” with inodilator effect improves myocardial contractility by sensitizing troponin C to calcium without increasing myocardial oxygen consumption and without impairing relaxation and diastolic function.

AIM: The aim of this study was to evaluate the effect of perioperative levosimendan compared to the conventional management used in the patient with poor left ventricular function undergoing cardiac surgery to reduce the need of post-operative pharmacological and mechanical circulatory support.

METHODS: It is prospective observational studies were patients undergoing cardiac surgery divided into two groups of 25 patients each. The first group received conventional management while the other group received levosimendan additionally duration and type of post-operative pharmacological support, duration of mechanical ventilation, durations of ICU and hospital stays, and major outcomes, and data about the need of mechanical support were collected.

RESULTS: In the levosimendan, fewer patients required vasoactive agents post-surgery (Noradrenaline) compared to the conventional group, yet the use of inotropic support (adrenaline) in the 2nd day and the need of mechanical circulatory support was equal in both groups. The mortality was equal in both groups.

CONCLUSION: Perioperative levosimendan may reduce the need of vasoactive agents postoperatively, but it does not reduce the need of inotropic nor mechanical support.
Correlation between Hyponatremia and Cluster of Differentiation 4 in Response to Highly Active Antiretroviral Therapy Treatment in Patients with Human Immunodeficiency Virus Cerebral Toxoplasmosis
Authors: Ritarwan Kiking , Pujiastuti R. A. Dwi , Ginting Petrus Nilwan
Published: July 2022

BACKGROUND: The proportion of HIV patients with hyponatremia was significantly higher in hospital compared to those without hyponatremia. HIV patients with hyponatremia had significantly lower CD4 cell counts, about twice the HIV viral load and an approximately four-fold higher prevalence. Hyponatremia was positively correlated with a decrease in CD4 cell count.

AIM: The aim of this study was to determine the correlation between hyponatremia and CD4 cells in response to HAART treatment in patients with HIV cerebral toxoplasmosis.

METHODS: The design of this study was correlative analytic with retrospective data collection method with secondary data sources obtained from the medical records of HIV-toxoplasma cerebral patients with hyponatremia at Haji Adam Malik Hospital Medan who met the inclusion and exclusion criteria and were included in this study. The research started from December 2021 to January 2022.

RESULT: This study was conducted on 30 samples of medical records consisting of 24 males and six females with a mean (min-max) age of 36.1 (23–53). There were 28 subjects (83.3%) with an effective response to treatment and two subjects (6.6%) with a less effective response to treatment. There was a significant correlation between hyponatremia and CD4 cells in response to HAART treatment (p < 0.005; r = 0.0462). There was a significant correlation between hyponatremia and CD4 cell count before receiving HAART treatment (p < 0.005; r = 0.0526).

CONCLUSION: There is a significant correlation between hyponatremia and CD4 cells in response to HAART treatment in patients with HIV cerebral toxoplasmosis.
Stunting Prevention Program of West Sumbawa Regency Health Office: A Qualitative Study in West Nusa Tenggara, Indonesia
Authors: Rizal Samsur , Sumarni Sumarni , Aji Arif Sabta , Fatimah Fatma Siti , Sarwadhamana Raden Jaka
Published: July 2022

BACKGROUND: Indonesia has included stunting in one of the Sustainable Development Goals targets. Stunting is a chronic undernutrition status during growth and development since early life which is caused by multidimensional factors. Prevalence of stunting rate in West Nusa Tenggara (NTB) remains high.

AIM: This study aimed to determine the implementing process to stunting prevention program in West Sumbawa’s Public Health Office, NTB Province, Indonesia.

METHODS: This was qualitative research design using case studies where the researcher carefully investigated a program, event, activity, process, or group of individuals. The population in this study were all staff of the West Sumbawa’s public health office, health facilities, and pregnant women in West Sumbawa Regency (KSB), NTB with purposive sampling. The data analysis was thematic analysis with the Colaizzi method.

RESULTS: Stunting Prevention Programs in 2019, there were 11 priority programs that were approved by the Government and Regional Apparatus Organization outpatient department of KSB, five priority programs for the locus stunting in Maluk district and 10 recommendation programs through the APBDes in KSB, and the flagship program in KSB was the Hearth. Based on local food (Kelor), the implementation of two programs from five priority programs in Mantun Village did not successful like optimizing parenting classes and alert village forums had less success as the inhibiting factors being the lack of participation of community human resources. The achievement of stunting prevalence reduction in KSB in 2018–2020 decreasing from 32.6% to 12.3% in NTB Province.

CONCLUSION: Program launched by West Sumbawa’s Public Health Office in 2019 has been running and implemented with several important notes related to community participation and monitoring from agencies related to the program that has been launched by the government KSB.
The Effectivity of IC50 Test between Green Tea and Curcumin Extracts from Mt. Lawu as an Antioxidant for SOD and MDA Levels in a Cisplatin Rat Model
Authors: Primadewi Novi , Kariosentono Harijono , Probandari Ari , Wiboworini Budiyanti
Published: July 2022

Abstract
Purpose: This study aims to determine the relationship of the effective dose between Mt. Lawu green tea and Mt. Lawu curcumin as antioxidants based on superoxide dismutase (SOD) and malondialdehyde (MDA) levels.
Methods: Blood was undertaken through the orbital sinus and allowed to stand until serum was formed. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) method was used to observe the effective dose of Mt. Lawu green tea and curcumin by quantifying the color change of each sample after incubation. The color change measured the absorbance value through a spectrophotometer. The data were analyzed using a correlation test to measure the effective concentration of Mt. Lawu green tea and Mt. Lawu curcumin toward SOD and MDA as antioxidant parameters in a cisplatin (CN) rat model.
Result: The study results show that the IC50 green tea concentration of 0.75 ± 0.16 µg/mL and the curcumin concentration of 5.3 ± 0.4 µg/mL can reduce 50% of DPPH. Based on the graphs, SOD increased and MDA decreased.
Discussion and Conclusion: This study demonstrates that the IC50 parameter of Mt. Lawu green tea and curcumin extracts is a good indicator for assigning the SOD and MDA levels in a CN rat model. Extracts derived from Mt. Lawu green tea and curcumin have ideal lowering DPPH, and the dosage has a strong relationship with the increase in SOD and the decrease in MDA.
Indonesian Ciplukan Extract Inhibited TGF-β1/NF-κB Pathway in Experimental Psoriasis Mouse Models
Authors: Sylviningrum Thianti , Wasita Brian , Purwanto Bambang , Kariosentono Harijono , Soetrisno Soetrisno
Published: July 2022

Background:The global prevalence of psoriasis, a chronic inflammatory skin disease, has substantially increased in the last decade. The increase activity of Transforming Growth Factor ß1 (TGFß1)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway which cause inflammation, is the major pathological mechanism in psoriasis. Current psoriasis treatment using chemical agents is hampered by the side-effects when used long-term, which underlines the need for alternative, low side-effect anti-psoriatic agents. The extract of Physalis angulata L., also known as Ciplukan in Indonesia, contains Physalins, compounds known for their anti-inflammatory effects, but whose effect on psoriasis has not been studied.
Objective:  This study aimed to investigate the effect of Ciplukan extract (CE) to TGFß1/NF-κB pathway in psoriasis mouse models.
Methods: This was experimental study with posttest-only control group design. The CE active ingredients were identified using Liquid chromatography-tandem mass spectrometry (LC-MS/MS). Twenty-five female imiquimod (IMQ) induced psoriasis-like dermatitis mice were allocated into five groups, with three groups receiving 7 days of 400, 800, and 1200 mg/kg bodyweight doses of CE, respectively, and two groups serving as control and IMQ groups. The NF-κB and TGFß1 expressions were evaluated using Allred score based on immunohistochemistry (IHC) staining. Histopathology and clinical psoriasis manifestations were assessed using Baker’s from Hematoxylin Eosin (HE) staining and Psoriasis Area Severity Index (PASI) scores. The Kruskal-Wallis followed by Mann Whitney tests were conducted for data analysis. The p-value < 0.05 was considered to be statistically different.  
Results: Based on LC-MS/MS test, Physalin B, D, and F were active ingredients from CE in ethyl acetate solution. An improvement in psoriasis inflammation was observed in 400 and 800 mg/kg bodyweight doses of CE, but only the dosage of 800 mg/kg BW significantly decreased of Allred scores from NF-κB and TGFß1 expressions; Baker’s and PASI scores compared to IMQ group (p<0.05). The 1200 mg/kg bodyweight doses of CE associated with acute toxicity signs and mortality, meanwhile dosage of 800 mg/kg BW showed the highest efficacy with lowest toxicity effect.
Conclusions: Ciplukan extract improved psoriasis manifestations via inhibition effect to TGFß1/NF-κB pathway and the extract might be developed as an alternative anti-psoriasis agent
Genetic diversity as a paramount factor determining wheat adaptation to drought stress
Authors: Georgieva Mariyana , Dimitrova Anna , Vassileva Valya
Published: July 2022

Wheat (Triticum aestivum L.) is a globally important crop for food and nutritional security that requires sufficient water supply for optimal production. All stages of wheat growth and development are adversely affected by reduced water supply, which limit productivity across large areas of Central and Southern Europe. Since drought episodes are expected to occur more frequently and with a greater intensity, the research efforts are devoted to identification of key traits associated with drought resistance that could be used as direct and indirect selection criteria for wheat drought tolerance. We evaluated and quantified several key genetic and molecular features of wheat genotypes with contrasting drought tolerance under severe dehydration triggered by the treatment of wheat with 250 mM sorbitol in hydroponic systems. Plant status was evaluated non-destructively by measuring leaf chlorophyll index, nitrogen content, and leaf relative water content. The drought-tolerant genotype displayed higher chlorophyll and nitrogen content, when grown under drought and benign conditions. Since root architecture appears to be a key trait for breeding against dehydration, we analysed the members of the DEEPER ROOTING (DRO) gene family that allow the root to penetrate deeper into soil, which could increase the yield even upon water shortage. Expression patterns of the DRO members showed genotype-specific changes under drought stress, which correlated well with plant drought tolerance. Our experiments suggest that genes affecting root system architecture could contribute to development of wheat cultivars with higher drought adaptability.
Simple and rapid LC-MS/MS method for determination of Piribedil in human plasma
Authors: Alshishani Anas , Hasan Inas , Ghanayem Fatima , Al-khasawneh Sewar , Abu Dayah Alaa
Published: July 2022

A sensitive, simple, and fast LC-MS/MS method of analysis was developed and validated for the determination of piribedil in human plasma. Piribedil was extracted by protein precipitation using acetonitrile and separated on C18 Phenomenex Gemini column (150 × 4.6mm, 5 µm) using isocratic elution of 75% of ammonium acetate buffer (10 mM) and 25% acetonitrile at a flow rate of 1 ml.min-1 over 5 min run time. Piribedil and d8-Piribedil, as internal standard, were detected and quantified in positive ion mode via MRM at m/z 299/135 and 307/135 for piribedil and d8–piribedil, respectively. The suggested method for piribedil was validated according to FDA and EMA guidelines. The standard calibration curve was linear over the concentration range of 3.4–5952 pg.ml-1. The intra-day precision was 2.45–9.94% and accuracy 92.78–99.97%. The inter-day precision was 2.14–5.47% and accuracy 95.73–101.99%. The recovery of analyte and IS was 96.94% and 111.18%, respectively. piribedil in plasma was stable at benchtop (short term) for 24 h, in autosampler tray for 48 h, in instrumentation room for 24 h (post-preparative), after 5 freeze-thaw cycles (–70 °C), and 11 days in the freezer (–70 °C). The validated method was successfully applied to a bioequivalence study of piribedil formulations involving 15 healthy Jordanian volunteers.
Three new genera and one new species of leaf insect from Melanesia (Phasmatodea, Phylliidae)
Authors: Cumming Royce T. , Le Tirant Stéphane
Published: July 2022

With the first large-scale Phylliidae molecular phylogeny recently published adding a great deal of clarity to phylliid diversity, several of the rarer species which could not be included were methodically and morphologically reviewed. This review resulted in identification of numerous substantial morphological features that suggest there are Melanesian clades that create polyphyletic groups within the phylliids which should instead be taxonomically recognized as unique. These rarer Melanesia species have historically been considered to be southern representatives of the Pulchriphyllium Griffini, 1898 sensu lato. However, there are notable morphological differences between the Pulchriphyllium sensu stricto and the “schultzei” group. Therefore, two new genera are erected, Vaabonbonphylliumgen. nov. from the Solomon Islands and Papua New Guinea and Rakaphylliumgen. nov. from New Guinea and the Aru Islands. Erection of these two new genera warrants the following new combinations: Rakaphyllium schultzei (Giglio-Tos, 1912), comb. nov., Rakaphyllium exsectum (Zompro, 2001b), comb. nov., and Vaabonbonphyllium groesseri (Zompro, 1998), comb. nov. Additionally, while reviewing material an undescribed Vaabonbonphyllium gen. nov. specimen was located and is herein described as Vaabonbonphyllium rafidahaegen. et sp. nov. from Mt. Hagen, Papua New Guinea. Additionally, a morphologically unique clade of several species recovered as sister to the Nanophyllium sensu stricto was recognized and their numerous unique morphological features and monophyly leads the authors to erect the new genus Acentetaphylliumgen. nov. which warrants the following new combinations: Acentetaphyllium brevipenne (Größer, 1992), comb. nov., Acentetaphyllium larssoni (Cumming, 2017), comb. nov., Acentetaphyllium miyashitai (Cumming et al. 2020), comb. nov., and Acentetaphyllium stellae (Cumming, 2016), comb. nov. With the addition of several new genera, a key to phylliid genera is included for adult males and females.
Les milieux communs
Authors: Taylan Ferhat
Published: July 2022

Le mouvement qui vise à accorder des droits à la nature, s’il répond à un souci écologique légitime, se fait au détriment de la démocratie. La considération des milieux de vie comme des communs, dont les humains sont des usagers, permet au contraire de faire de l’écologie un enjeu démocratique.
Les transformations de l’action publique
Authors: Mauguin Philippe , Soriano Sébastien , Tavernier Jean-Luc , Gilli Frédéric , Sablic Laurent , Braune Camille
Published: July 2022

Les directeurs de trois grands instituts nationaux éclairent les recompositions récentes de l’action publique. S’ils insistent sur l’importance de leur autonomie, dans un contexte de plus en plus concurrentiel, ils souhaitent renforcer la confiance des citoyens et des salariés vis-à-vis de l’État.
Impact of the strong Allee effect in a predator-prey model
Authors: Ma Yudan , Zhao Ming , Du Yunfei
Published: July 2022

In this work, we propose and investigate a new predator-prey model with strong Allee effect in prey and Holling type Ⅱ functional response in predator. By performing a comprehensive dynamical analysis, we first derive the existence and stability of all the possible equilibria of the system and the system undergoes two transcritical bifurcations and one Hopf-bifurcation. Next, we have calculated the first Lyapunov coefficient and find the Hopf-bifurcation in this model is supercritical and a stable limit cycle is born. Then, by comparing the properties of the system with and without Allee effect, we show that the strong Allee effect is of great importance to the dynamics. It can drive the system to instability. Specifically, Allee effect can increase the extinction risk of populations and has the ability to switch the system's stability to limit cycle oscillation from stable node. Moreover, numerical simulations are presented to prove the validity of our findings.
Structural stability for the Darcy model in double diffusive convection flow with Magnetic field effect
Authors: Guo Zhanwei , Shi Jincheng
Published: July 2022

In this paper, we consider the Darcy model with magnetic field affect which is used to describe the double diffusive flow of a fluid containing a solute. Using the energy estimate methods, we derive the prior bounds of the solutions. By using these a prior bounds, the continuous dependence of the solutions to Darcy model on the magnetic coefficient and the boundary parameter is established.
An epidemic-economic model for COVID-19
Authors: Bai Jie , Wang Xiunan , Wang Jin
Published: July 2022

In this paper, we propose a new mathematical model to study the epidemic and economic consequences of COVID-19, with a focus on the interaction between the disease transmission, the pandemic management, and the economic growth. We consider both the symptomatic and asymptomatic infections and incorporate the effectiveness of disease control into the respective transmission rates. Meanwhile, the progression of the pandemic and the evolution of the susceptible, infectious and recovered population groups directly impact the mitigation and economic development levels. We fit this model to the reported COVID-19 cases and unemployment rates in the US state of Tennessee, as a demonstration of a real-world application of the modeling framework.
From Berlin to the Coral Sea
Authors: Margariti Roxani Eleni
Published: July 2022

In 1820 two young Prussian naturalists secured funds to travel to Egypt and the Levant and collect samples for Berlin’s budding zoological collections. Three years later, Wilhelm Friedrich Hemprich and Christian Gottfried Ehrenberg extended their research to the Red Sea, eventually reaching as far as the coast of Abyssinia, present-day Eritrea. Their journeys were marked by tragedy, yet their efforts led to early publications of Red Sea natural history that have been influential even if little known outside of scientific circles. More importantly, their drawings and observations offer a fascinating window onto routes and natural conditions on both coasts of the Red Sea and its islands and onto the networks of knowledge – crucially involving local interlocutors – from which modern scientific descriptions of that natural world developed. This study highlights published and unpublished materials from the Hemprich‑Ehrenberg expedition in the Red Sea and argues that its Nachlass constitutes an informative time capsule of scientific travel networks in the region as well as a palimpsest of local knowledge, particularly regarding maritime topography and marine and insular life.
Learning to write and read at Didymoi
Authors: Lougovaya Julia
Published: July 2022

The excavations of the Roman military fort of Didymoi in the Eastern Desert have yielded significant number of ostraca that can be associated with learning to write and read. While chronologically this evidence spans the two centuries of the fort’s existence, the nature of texts and their chronological distribution are far from homogenous. Taking into account the distinction between systematic school curriculum and ad hoc acquisition of immediately applicable skills, this paper aims to give a diachronic overview of educational practices at the fort.
An Indian coin in the Eastern Desert of Egypt
Authors: Bhandare Shailendra , Cuvigny Hélène , Faucher Thomas
Published: July 2022

In 2007, the French archaeological mission of the Eastern Desert found a square Indian coin during the excavations of the praesidium of Dios (Abu Qurayya). Located on the road from Koptos to Berenike, the fort was built in 115/116 AD. The coin is a new type in the series of the “stock coinage” of the Cheras, of South India, usually dated from the 1st and 2nd centuries AD. It is the only Indian coin ever found by the team during more than 25 years of excavations in the praesidia of the Eastern Desert and a rare witness of Erythrean trade in one of these Roman garrisons. If its presence is only anecdotic, its stratigraphic context helps to date the Chera coinage.
Le design des dispositifs d’automesure du sommeil
Authors: Calvignac Cédric
Published: July 2022

Cet article porte sur l’analyse de brevets d’invention américains dédiés à la mesure et à la gestion du sommeil. Il s’intéresse plus précisément aux inventions permettant l’automesure du temps et de la qualité du sommeil par l’usage d’objets connectés (ou quantified sleep). L’objectif poursuivi consiste à rendre compte des transformations suggérées par ces inventions dans la prise en charge individuelle et collective d’un problème de santé publique majeur : celui du manque de sommeil. Une attention particulière sera ici portée à la façon dont ces technologies de quantification de soi (quantified self) appellent à une redistribution des responsabilités individuelles et collectives en matière de bien-être et de santé. Les solutions proposées participent-elles du mouvement général de « médicalisation du quotidien » ? De quelle manière ? Prévoient-elles de responsabiliser davantage l’individu, de lui permettre de devenir un acteur autonome de sa santé ? Comment intègrent-elles la consultation ou non d’un tiers expert ou médical ? Comment ces brevets d’invention du quantified sleep prennent-ils en considération les collectifs auxquels appartiennent les usagers (famille et entreprise notamment) ? Autant de questions auxquelles cet article propose des éléments de réponse à l’appui d’un travail documentaire de grande ampleur portant sur 614 demandes de brevets déposées auprès de l’United States Patent and Trademark Office.
Le RGPD et la protection de la vie privée face à l’essor des objets connectés
Authors: DONADIEU Gwenaëlle
Published: July 2022

L’essor des objets connectés dans l’environnement des consommateurs conduit au traitement, par des professionnels, d’une grande quantité d’informations plus ou moins sensibles. Certains objets connectés peuvent en effet être dangereux pour la vie privée des consommateurs en raison de l’atteinte qui pourrait résulter de la diffusion de ces informations. Si le Règlement général sur la protection des données (RGPD) impose diverses obligations au responsable de traitement, comme une obligation d’information et de transparence ainsi que le recueil d’un consentement clair de la part de l’utilisateur lors d’un traitement de données personnelles, nous pouvons nous interroger sur les modalités de mise en œuvre de ces dispositions. Les chercheurs en économie comportementale ayant mis en exergue le fonctionnement du processus décisionnel des individus, il est désormais possible de mieux comprendre pourquoi certaines dispositions ne sont pas aussi efficaces qu’escomptées.
Dynamiques des échanges numériques autour d’un sujet controversé : le cas du forum Homéopathie sur le site Doctissimo
Authors: DEMONCEAUX Sophie
Published: July 2022

La controverse scientifique autour de l’homéopathie occupe une place importante en ligne : sur les réseaux sociaux, à travers les commentaires liés à des articles et sur les forums de discussion. Notre article s’intéresse aux interactions entre les participants du forum Homéopathie sur le site d’information santé Doctissimo. L’objectif est d’observer si la mise en débat d’un sujet controversé tel que l’homéopathie est possible sur ces dispositifs participatifs. Notre approche qualitative s’appuie sur la méthode de la théorisation ancrée : nous avons mené une analyse des publications faites en 2017 et 2018, années où le débat autour de la question du déremboursement était particulièrement vif. Après avoir présenté la particularité du terrain d’enquête et du corpus, nous verrons dans quelle mesure ce forum de discussion peut ou non être considéré comme un prolongement de l’espace public, une arène 2.0 permettant la mise en œuvre d’un débat entre internautes.
Cyberharcèlement au travail et messagerie électronique
Authors: DUPRÉ Delphine
Published: July 2022

Cet article traite du phénomène du harcèlement au travail et vise à prolonger, à partir d’une enquête empirique, une réflexion initiée après une revue de la littérature sur ce thème publiée en 2018. Nous nous demandons de quelles manières la messagerie électronique s’inscrit dans un processus de harcèlement et contribue à le redéfinir. Nous avons collecté les témoignages de cadres intermédiaires qui s’estimaient victimes de harcèlement professionnel. L’analyse par théorisation ancrée de nos témoignages démontre qu’il existe une continuité entre le harcèlement en présentiel et le harcèlement par messagerie électronique. Les propriétés sociotechniques de la messagerie électronique contribuent également à redéfinir les traits saillants du harcèlement : l’intention de nuire, l’intensité des actes, la répétition et le déséquilibre des pouvoirs. Le recours aux courriels favorise également l’émergence de violences de groupe potentialisées par les ressources numériques. Nous observons enfin des phénomènes de discrimination amplifiés par les usages des courriels, qui conduisent à l’exclusion des publics vulnérables et « non-conformes ».
Médiation du cinéma documentaire et pratiques des abonnés cinéphiles de Tënk
Authors: GANTIER Samuel
Published: July 2022

Cet article interroge les logiques de médiation du documentaire de création sur la plateforme de vidéo à la demande Tënk. L’originalité méthodologique de cette recherche-action est d’analyser les usages des abonnés à travers la conception d’un prototype interactif. Cet artefact est évalué en ayant recours à un protocole empirique qui analyse la réception d’un panel de dix utilisateurs cinéphiles de la plateforme. L’étude présente tout d’abord l’appropriation d’une proposition éditoriale qui combine les modèles sur abonnement (SVOD) et en visionnement à l’acte (VOD). Dans un deuxième temps, l’expérimentation met en avant les conditions nécessaires pour concevoir un système de recommandation sociale au sein d’une communauté d’abonnés qui partagent un goût commun pour le cinéma documentaire.