bluuebunny/crossref_metadata_2025 huggingface dataset:
Malnutrition in Amyotrophic Lateral Sclerosis: Insights from Morphofunctional Assessment and Global Leadership Initiative on Malnutrition Criteria
Authors: Zarco-Martín María Teresa , Freire Carmen , Andreo-López María Carmen , Leyva-Martínez Socorro , Fernández-Soto María Luisa
Published: August 2024

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease frequently accompanied by malnutrition due to weight loss, increased energy expenditure, and muscle mass loss. This study aimed to evaluate morphofunctional assessment tools as predictors of malnutrition and to investigate their relationship with muscle status and disease severity in ALS patients. A cross-sectional study was conducted with 45 ALS patients at the San Cecilio University Hospital in Granada. Malnutrition was assessed using the Global Leadership Initiative on Malnutrition (GLIM) criteria. Morphofunctional assessment was performed using Bioimpedance Vectorial Analysis (BIVA), handgrip strength (HGS), and Short Physical Performance Battery (SPPB). Malnutrition prevalence was 38% according to GLIM criteria. Significant differences were observed between malnourished and non-malnourished groups in age (70 ± 9 vs. 62 ± 10 years, p = 0.01), sex (female prevalence: 58.8% vs. 25.0%, p = 0.02), dysphagia prevalence (83% vs. 29%, p < 0.001), PEG/PRG use (35.3% vs. 3.6%, p = 0.01), and ALSFRS-R scores (30 ± 12 vs. 34 ± 12, p = 0.02). Malnourished patients had lower values in anthropometric measurements, muscle mass obtained by BIVA, and phase angle (PA) (4.05 ± 0.8° vs. 5.09 ± 0.8°, p < 0.001). No significant differences were found in muscle strength or functional status. PA showed significant correlations with muscle strength (r = 0.52, p < 0.001) and muscle mass measures (r = 0.48, p < 0.001). Moreover, PA was associated with poorer disease progression and physical performance. In our sample, BIVA metrics such as PA (<4.3°), SPA (<−0.8), body cell mass (<9.2 kg/m), and extracellular water (>49.75%) were identified as malnutrition risk factors. The study underscores the critical importance of comprehensive morphofunctional assessment and the use of advanced diagnostic criteria, for early identification and intervention in malnutrition among people with ALS. Further research is warranted to validate these findings and develop targeted nutritional strategies into routine clinical practice.
Frailty Is Associated with Malnutrition–Inflammation Syndrome in Older CKD Patients
Authors: Molinari Paolo , Caldiroli Lara , Abinti Matteo , Nardelli Luca , Armelloni Silvia , Cesari Matteo , Castellano Giuseppe , Vettoretti Simone
Published: August 2024

Patients affected by chronic kidney disease (CKD) are generally considered to be frailer than those with preserved renal function. We cross-sectionally evaluated the associations between frailty, malnutrition–inflammation syndrome and circulating inflammatory cytokines in 115 older individuals with advanced CKD. As for frailty definition, we adopted Fried’s frailty phenotype (FP), while malnutrition–inflammation syndrome was assessed using the Malnutrition–Inflammation Score (MIS) and circulating inflammatory cytokines (IL-6; TNFα; MCP-1). A total of 48 patients were frail, and mean eGFR was comparable in both frail and non-frail patients (24 ± 10 vs. 25 ± 11 mL/min/1.73 m2; p = 0.63). Frail patients had higher MIS (6 [4–11] vs. 4 [3–5]; p < 0.0001) but cytokine concentrations were comparable in both groups. At multivariate regression, FP was independently associated with MIS, age, gender and pre-albumin but not with cytokines. However, we found some associations between inflammatory cytokines and some specific frailty criteria: weight loss and slowness were associated with MCP-1 (respectively p = 0.049 and p < 0.0001) and weakness with IL-6 (p = 0.005); in conclusion, in older patients with advanced CKD, frailty is strictly associated with malnutrition–inflammation syndrome but not with circulating inflammatory cytokines.
Silymarin: A Natural Compound for Obesity Management
Authors: de Freitas Jessica Alves , Santamarina Aline Boveto , Otoch José Pinhata , Pessoa Ana Flávia Marçal
Published: August 2024

Silybum marianum (L.) Gaertn, commonly known as milk thistle, is an herbal medicine rich in silymarin, a bioflavonoid complex. Historically, silymarin was used for treating liver diseases, but recent studies highlight silymarin’s potential for obesity management. This narrative review aims to provide an in-depth examination of the existing knowledge of Silybum marianum (L.) and its secondary compounds concerning obesity and associated comorbidities, summarizing data from in vitro, preclinical, and clinical studies. Obesity is a significant public health issue, exacerbated during the COVID-19 pandemic, as a major risk factor for mortality. It contributes to metabolic dysfunction, including oxidative stress, metainflammation, cardiovascular diseases, and type 2 diabetes development. Silymarin has demonstrated benefits on insulin signaling and lipid metabolism, as well as antioxidant and anti-inflammatory properties at the molecular level. Innovative studies also suggest silymarin’s potential as a prebiotic, positively influencing gut microbiota composition, a key factor affected by obesity. These promising findings support the potential anti-obesity action of silymarin in clinical practice. Looking forward, using silymarin as an innovative complementary therapy could offer substantial benefits for natural health promotion and obesity management. Nevertheless, further research into optimal doses and cellular mechanisms is still needed.
Neutron Star–Dark Matter Admixed Objects in the Mass Gap Region
Authors: Vikiaris Michael
Published: August 2024

To this day, the nature of dark matter (DM) remains elusive despite all our efforts. This type of matter has not been directly observed, so we infer its gravitational effect. Since galaxies and supermassive objects like these are most likely to contain DM, we assume that dense objects such as neutron stars (NSs) are also likely to host DM. The NS is considered the best natural laboratory for testing theories and collecting observational data. We mainly focus on two types of DM particles, fermions and bosons, with a mass range of [0.01–1.5] GeV and repulsive interactions of about [10−4–10−1] MeV−1. Using a two-fluid model to solve the TOV equations, we find stable configurations that span hundreds of kilometers and weigh tens or even hundreds of solar masses. To visualize results, we think of a giant invisible compact DM object and the NS in the center as the core, the only visible part. Stability criteria are met for these configurations, so collapsing into a black hole is unlikely. We go further and use this work for smaller formations that exist inside the mysterious Mass Gap. We also find stable configurations of 3–4 solar masses, with NS-DM mixing capable of describing the mass gap. Regardless, the present theoretical prediction, if combined with corresponding observations, could shed light on the existence of DM and even more on its fundamental properties.
BacSPaD: A Robust Bacterial Strains’ Pathogenicity Resource Based on Integrated and Curated Genomic Metadata
Authors: Ribeiro Sara , Chaumet Guillaume , Alves Karine , Nourikyan Julien , Shi Lei , Lavergne Jean-Pierre , Mijakovic Ivan , de Bernard Simon , Buffat Laurent
Published: August 2024

The vast array of omics data in microbiology presents significant opportunities for studying bacterial pathogenesis and creating computational tools for predicting pathogenic potential. However, the field lacks a comprehensive, curated resource that catalogs bacterial strains and their ability to cause human infections. Current methods for identifying pathogenicity determinants often introduce biases and miss critical aspects of bacterial pathogenesis. In response to this gap, we introduce BacSPaD (Bacterial Strains’ Pathogenicity Database), a thoroughly curated database focusing on pathogenicity annotations for a wide range of high-quality, complete bacterial genomes. Our rule-based annotation workflow combines metadata from trusted sources with automated keyword matching, extensive manual curation, and detailed literature review. Our analysis classified 5502 genomes as pathogenic to humans (HP) and 490 as non-pathogenic to humans (NHP), encompassing 532 species, 193 genera, and 96 families. Statistical analysis demonstrated a significant but moderate correlation between virulence factors and HP classification, highlighting the complexity of bacterial pathogenicity and the need for ongoing research. This resource is poised to enhance our understanding of bacterial pathogenicity mechanisms and aid in the development of predictive models. To improve accessibility and provide key visualization statistics, we developed a user-friendly web interface.
Respiratory Syncytial Virus: The Urgent Need for Innovative Preventive Strategies
Authors: Virgili Fabrizio , Midulla Fabio , de Benedictis Fernando Maria
Published: August 2024

Respiratory Syncytial Virus (RSV) is a medium-sized enveloped Pneumovirus belonging to the Paramyxoviridae family [...]
The Influence of the Dominant Leg in Body Asymmetries in Children and Adolescent Male Soccer Players
Authors: Theodorou Eleni , Grivas Theodoros B. , Hadjicharalambous Marios
Published: August 2024

The current study aimed to examine (a) whether the dominant leg (DL) was associated with the contralateral side of functional scoliosis and (b) if any of the postural asymmetries’ evaluation variables may be a reliable predictor of the functional scoliosis development in young male soccer players. Six hundred-nine (n = 609) male soccer players (age: 10.8 ± 2.7 years; height: 147 ± 17 cm; weight: 43.4 ± 14.6 kg; DL: Right 81.6%, Left 14%, Both 4.4%) participated in this study. The spinal asymmetries evaluation included thoracic kyphosis, lumbar lordosis, truncal rotation, shoulders alignment from posterior view, anterior and posterior pelvic tilt, anterior superior iliac spine (ASIS), hamstring tightness, and lower extremities discrepancy. A significant association was observed between the DL and the truncal rotation side: χ2(4) = 30.84, p = 0.001, V = 0.16. Participants with longer left legs were likelier to present a spinal asymmetry (OR = 1.18). The participants with higher left shoulders were 2.13 times more likely to have spinal asymmetry than the participants with normal shoulders level. Participants with left ASIS higher were 3.08 times more likely to present asymmetry than those with normally aligned ASIS levels. There was also a significant association between the DL and the side of truncal rotation: χ2(2) = 13.30, p = 0.001, V = 0.449. Logistic regression analysis for the functional scoliotic group and truncal rotation side demonstrated that the taller participants and participants with shorter right legs were more likely to have asymmetry on the left side (OR = 1.29, OR = 0.32). Participants with greater right hamstring stiffness were likelier to have a truncal rotation on the right side (OR = 0.93). Participants with higher left shoulders were 0.20 times less likely to have a truncal rotation on the left side than the participants with normal shoulders level. In conclusion, leg dominance in children and in youth soccer players may be a factor causing truncal rotation on the contralateral side. Additional causes, such as leg length discrepancy and pelvic tilt, may progressively lead to functional scoliosis.
Comparative Analysis of the Characteristics of Two Hardy Kiwifruit Cultivars (Actinidia arguta cv. Cheongsan and Daebo) Stored at Low Temperatures
Authors: Eo Hyun Ji , Kim Chul-Woo , Lee Uk , Kim Yonghyun
Published: August 2024

A cold storage system is useful for maintaining the quality of hardy kiwifruit. However, extended cold storage periods inevitably result in cold stress, leading to lower fruit marketability; the severity of chilling injury depends on fruit types and cultivars. In this study, the impact of cold storage conditions on the physicochemical properties and antioxidant capacity of two phenotypically different hardy kiwifruit cultivars—‘Cheongsan’ (large type) and ‘Daebo’ (small type)—stored at low (L; 3 °C, relative humidity [RH]; 85–90%) and moderate-low (ML; 5 °C, RH; 85–90%) temperatures was determined. Significant differences in fruit firmness and titratable acidity between treatments L and ML were observed in both cultivars during the experimental storage period. Meanwhile, the browning and pitting rates of the ‘Cheongsan’ fruits in treatment L increased for 8 weeks compared with those of the ‘Daebo’ fruits in treatments L and ML; nonetheless, fruit decay was observed in the ‘Daebo’ fruits in treatment ML after 6 weeks. The total chlorophyll, carotenoid, flavonoid, and ascorbic acid concentrations as well as the antioxidant activities of both the cultivars significantly differed between treatments L and ML. After 2 weeks of storage, the ‘Cheongsan’ fruits in treatment L had lower antioxidant activities and ascorbic acid content than those in treatment ML. These results demonstrate that the quality attributes and antioxidant activity of hardy kiwifruit are influenced by the low-temperature storage conditions and the specific kiwifruit cultivars. Our findings suggest that optimal cold storage conditions, specific to each hardy kiwifruit cultivar, promise to maintain fruit quality, including their health-promoting compounds, during long-term storage.
Environmental Filters Structure Cushion Bogs’ Floristic Composition along the Southern South American Latitudinal Gradient
Authors: Figueroa-Ponce Felipe , Hinojosa Luis Felipe
Published: August 2024

The environmental filtering hypothesis predicts that abiotic factors restrict communities by selecting species capable of survival and persistence under specific conditions, resulting in variations in beta diversity, phylogenetic clustering, and niche differentiation among communities when studying environmental gradients. Cushion bogs and high-altitude wetlands along the Andes display homogeneous flora contrasting with zonal vegetation. Despite being influenced by microclimatic conditions, these ecosystems are subject to diverse environmental effects. Here, we test the environmental filtering hypothesis on the structure of cushion bog communities along a broad-scale latitudinal gradient from 15° S to 42° S. We analyzed 421 bogs and 293 species across three macroclimatic regions with distinct summer, winter, and transitional arid rainfall regimes. Using variance partitioning and membership-based regionalization models, we examined the impacts of climatic, edaphic, and spatial variables on beta diversity. We also assessed species’ niche overlap and the influence of environmental filters on the communities’ phylogenetic diversity. Results show that species turnover and niche overlap vary with macroclimatic differences, delineating three distinct regions. Notably, phylogenetic clustering in the driest part of the gradient (23° S–24° S) highlights the impact of environmental filtering. Aridity and temperature variations at a broad scale serve as environmental filters shaping the composition of bog communities across southern South America.
Foliar Co-Applications of Nitrogen and Iron on Vines at Different Developmental Stages Impacts Wine Grape (Vitis vinifera L.) Composition
Authors: Fu Xiaoke , Chen Xi , Chen Yiwen , Hui Yueran , Wang Rui , Wang Yaqi
Published: August 2024

The co-application of N and Fe can improve wine grape composition and promote the formation of flavor compounds. To understand the effects of foliar co-application of N and Fe on wine grape quality and flavonoid content, urea and EDTA-FE were sprayed at three different developmental stages. Urea and EDTA-Fe were sprayed during the early stage of the expansion period, at the end of the early stage of the expansion period to the late stage of the veraison period, and during the late stage of the veraison period. The results demonstrated that the co-application of urea and EDTA-Fe, particularly N application during the late stage of the veraison period and Fe application during the early stage of the berry expansion period (N3Fe1), significantly improved grape quality. Specifically, the soluble solid content of berries increased by 2.78–19.13%, titratable acidity decreased by 6.67–18.84%, the sugar-acid ratio became more balanced, and yield increased by 13.08–40.71%. Further, there was a significant increase in the relative content of amino acids and flavonoids. In conclusion, the application of Fe and N fertilizers at the pre-expansion and late veraison stages of grapes can significantly improve the quality and yield of berries; ultimately, this establishes a foundation for future improvement in the nutritional value of grapes and wine.
Antidepressant- and Anxiolytic-like Effects of Pomegranate: Is It Acting by Common or Well-Known Mechanisms of Action?
Authors: Estrada-Camarena Erika , López-Rubalcava Carolina , Vega-Rivera Nelly , González-Trujano María
Published: August 2024

The pharmacological effects of pomegranates have been described considering metabolic aspects such as hypoglycemic and hypolipidemic activities. The pomegranate extract has activity on the central nervous system (CNS) as a natural antidepressant and anxiolytic. The chemical composition of pomegranates is complex since the bioactive compounds are multiple secondary metabolites that have been identified in the extracts derived from the peel, seed, flowers, leaves, or in their combination; so, it has not been easy to identify an individual compound as responsible for its observed pharmacological properties. From this point of view, the present review analyzes the effects of crude extracts or fractions of pomegranates and their possible mechanisms of action concerning antidepressant- and anxiolytic-like effects in animal models. Serotonin receptors, estrogen receptors, the peroxisome proliferator-activated receptor gamma (PPARγ), or monoamine oxidase enzymes, as well as potent antioxidant and neuroplasticity properties, have been described as possible mediators involved in the antidepressant- and anxiolytic-like behaviors after pomegranate treatment. The pharmacological effects observed on the CNS in experimental models associated with a specific stress level suggest that pomegranates could simultaneously modulate the stress response by activating several targets. For the present review, scientific evidence was gathered to integrate it and suggest a possible pathway for mediators to be involved in the mechanisms of action of the pomegranate’s antidepressant- and anxiolytic-like effects. Furthermore, the potential benefits are discussed on comorbid conditions with anxiety and depression, such as perimenopause transition and pain.
Adaptation of the Invasive Plant Sphagneticola trilobata (L.) Pruski to Drought Stress
Authors: Zhang Qilei , Wang Ye , Weng Zhilong , Chen Guangxin , Peng Changlian
Published: August 2024

Invasive species and their hybrids with native species threaten biodiversity. However, there are few reports on the drought stress adaptability of invasive species Sphagneticola trilobata (L.) Pruski and its hybrid with native species S. calendulacea. In this study, relative water content (RWC), abscisic acid (ABA), reactive oxygen species, antioxidant capacity, and photosynthetic capacity were measured in the hybrid and its parents under drought stress (13% PEG-6000). Under drought stress, the ABA content and RWC in S. trilobata were the highest. RWC decreased by 28% in S. trilobata, 41% in S. calendulacea, and 33% in the hybrid. Activities of the antioxidant enzymes in S. trilobata were the highest, and the accumulation of malondialdehyde (MDA) was the lowest (4.3 μg g−1), while it was the highest in S. calendulacea (6.9 μg g−1). The maximum photochemical efficiency (Fv/Fm) of S. calendulacea was the lowest (0.71), and it was the highest in S. trilobata (7.5) at 8 h under drought stress. The results suggest that the drought resistance of the hybrid was weaker than that of S. trilobata but stronger than that of S. calendulacea. Therefore, the survival of S. calendulacea may be threatened by both the invasive species S. trilobata and the hybrid.
Toughening Polylactic Acid with Ultrafine Fully Vulcanized Powdered Natural Rubber Graft-Copolymerized with Poly(styrene-co-acrylonitrile): Tailoring the Styrene–Acrylonitrile Ratio for Enhanced Interfacial Interactions
Authors: Gholami Reza , Lawan Ibrahim , Ebrahimi Sahar , Pattulee Achiraya , Ahn Cheol-Hee , Rimdusit Sarawut
Published: August 2024

This study investigated the sustainable toughening of polylactic acid (PLA) by incorporating ultrafine fully vulcanized powdered natural rubber graft-copolymerized with poly-styrene-co-acrylonitrile (UFPNR-SAN). We investigated the effect of the styrene-to-acrylonitrile ratio (ST:AN) used during the grafting process on the final UFPNR-SAN compatibility with PLA. The ST:AN ratio was systematically varied during the grafting reaction to prepare UFPNR-SAN with a range of different surface energies. The ST:AN ratio of 4:1 showed the highest compatibility with the PLA matrix, attributed to optimal interfacial interactions and improved dispersion, as indicated by contact angle measurements and SEM observations. This resulted in a remarkable toughening of the PLA/UFPNR-SAN composite. For instance, an obvious fully ductile behavior without crack formation and flexural strain of around 17.5% against 5% of the neat PLA was recorded. In addition, 3.5 times improvement in the impact strength of the composite at 25 wt% dosage of the UFPNR-SAN was also achieved without compromising thermal properties. Overall, this study established the suitable ST:AN ratio on the grafting onto natural rubber to enhance interfacial interactions with PLA and its effects on the properties of the resulting PLA/UFPNR-SAN bio-based composite.
The Buffer Capacity of Polyelectrolyte Microcapsules Depends on the Type of Template
Authors: Dubrovskii Alexey V. , Kim Aleksandr L. , Tikhonenko Sergey A.
Published: August 2024

One of the key physicochemical parameters of polyelectrolyte microcapsules (PMCs) is their buffer capacity (BC). The BC of the microcapsules allows for an assessment of the change in protonation state across the entire polyelectrolyte system, which directly impacts the buffer barrier of PMCs, as well as the stability and physical properties of their shell. However, the buffer capacity of PMCs and their behavior under changes in ionic strength and temperature can differ depending on the type of core used to form the microcapsules. As part of this study, we revealed the buffer capacity (BC) of polyelectrolyte microcapsules formed on polystyrene cores (PMCPs) and studied the influence of ionic strength and environmental temperature on the BC of these capsules. We found that the buffer capacity of PMCPs differs from the BC of water at a pH above 8; the addition of sodium chloride leads to an increase in buffer capacity in alkaline conditions, and conversely, thermal treatment leads to its decrease at a pH of 9. The results obtained are different from the BC of polyelectrolyte microcapsules formed on CaCO3 cores, which suggests a difference in the physicochemical properties of these types of capsules. The buffer capacity of polyelectrolyte microcapsules depends on the type of template used.
The Role of the Vitamin D Receptor in the Epidermal Stem Cell Response to Wounding
Authors: Bikle Daniel D.
Published: August 2024

Chronic skin wounds are estimated to affect 6.5 million patients in the US, at a cost of over USD 25 billion. Efforts to prevent and/or treat such wounds will result in reduced morbidity and economic losses. This project is focused on the role of vitamin D signaling in the epidermis in the control of stem cell (SC) activation and function during the initial response to the wounding of the skin, a response that, if defective, contributes to poor wound healing or cancer. In this review, I first describe the anatomy of the skin, focusing first on the epidermis, describing the different cell layers which in a spatial way also represent the differentiation process of the interfollicular epidermis (IFE) as it undergoes continuous regeneration. I then describe the other components of the skin, particularly the hair follicle (HF), which undergoes a cyclic pattern of regeneration. Adult SCs residing in these regenerative tissues play essential roles in the maintenance of these tissues. However, when the skin is wounded, the progeny of SCs from all regions of the HF and IFE contribute to the healing process by changing their initial cell fate to take on an epithelial genotype/phenotype to heal the wound. Although earlier lineage tracing studies helped to define the contributions SCs from the different niches made to wound healing, scRNAseq studies have demonstrated a considerably more nuanced picture. The role of vitamin D signaling will be introduced by reviewing the unique role played by the epidermal keratinocyte first in producing vitamin D and then in metabolizing it into its active form 1,25(OH)2D. 1,25(OH)2D is the principal ligand for the vitamin D receptor (VDR), a transcription factor that helps to mediate the genomic changes in the stem cells in their response to wounding. In these actions, the VDR is regulated by coregulators, of which the steroid receptor coactivator complexes SRC 2 and 3 and the mediator complex (MED) play essential roles. The VDR generally acts in association with other transcription factors such as p63 and β-catenin that can colocalize with the VDR in the genes it regulates. Although much remains to be understood, the role of the VDR in the stem cell response to wounding is clearly essential and quite different from its classic roles in regulating calcium metabolism, although calcium is essential for the actions of vitamin D signaling in the skin.
More than Daughters: Women’s Experiences at Southern Baptist Colleges during the Progressive Era
Authors: Lile Joanna
Published: August 2024

This article examines students’ experiences at Southern Baptist colleges that educated women during the Progressive era (1880–1920). Denominational leaders and school faculty attempted to recreate Christian home life on college campuses by tightly restricting students’ freedoms and behavior. This article examines female college students’ publications to better understand their views on family and home life on the college campus. Their writings indicate that students did believe that the college was like a family. However, students reinterpreted the meaning of home life and family on the college campus by reimagining the use of residential space, developing alternative hierarchical and intimate relationships on campus, and exercising more autonomy over their religious rituals.
Monitoring Changes in the Enhanced Vegetation Index to Inform the Management of Forests
Authors: Rodriguez Peter S. , Schwantes Amanda M. , Gonzalez Andrew , Fortin Marie-Josée
Published: August 2024

In the absence of forest ecosystem time series data, monitoring proxies such as the enhanced vegetation index (EVI) can inform the capacity of forests to provide ecosystem services. We used MODIS-derived EVI at 250 m and 16-day resolution and Breaks for Additive and Seasonal Trend (BFAST) algorithms to monitor forest EVI changes (breaks and trends) in and around the Algonquin Provincial Park (Ontario, Canada) from 2003 to 2022. We found that relatively little change occurred in forest EVI pixels and that most of the change occurred in non-protected forest areas. Only 5.3% (12,348) of forest pixels experienced one or more EVI breaks and 27.8% showed detectable EVI trends. Most breaks were negative (11,969, 75.3%; positive breaks: 3935, 24.7%) with a median magnitude of change of −755.5 (median positive magnitude: 722.6). A peak of negative breaks (2487, 21%) occurred in the year 2013 while no clear peak was seen among positive breaks. Most breaks (negative and positive) and trends occurred in the eastern region of the study area. Boosted regression trees revealed that the most important predictors of the magnitude of change were forest age, summer droughts, and warm winters. These were among the most important variables that explained the magnitude of negative (R2 = 0.639) and positive breaks (R2 = 0.352). Forest composition and protection status were only marginally important. Future work should focus on assessing spatial clusters of EVI breaks and trends to understand local drivers of forest vegetation health and their potential relation to forest ecosystem services.
Evaluating Federated Learning Simulators: A Comparative Analysis of Horizontal and Vertical Approaches
Authors: Elshair Ismail M. , Khanzada Tariq Jamil Saifullah , Shahid Muhammad Farrukh , Siddiqui Shahbaz
Published: August 2024

Federated learning (FL) is a decentralized machine learning approach whereby each device is allowed to train local models, eliminating the requirement for centralized data collecting and ensuring data privacy. Unlike typical typical centralized machine learning, collaborative model training in FL involves aggregating updates from various devices without sending raw data. This ensures data privacy and security while collecting a collective learning from distributed data sources. These devices in FL models exhibit high efficacy in terms of privacy protection, scalability, and robustness, which is contingent upon the success of communication and collaboration. This paper explore the various topologies of both decentralized or centralized in the context of FL. In this respect, we investigated and explored in detail the evaluation of four widly used end-to-end FL frameworks: FedML, Flower, Flute, and PySyft. We specifically focused on vertical and horizontal FL systems using a logistic regression model that aggregated by the FedAvg algorithm. specifically, we conducted experiments on two images datasets, MNIST and Fashion-MNIST, to evaluate their efficiency and performance. Our paper provides initial findings on how to effectively combine horizontal and vertical solutions to address common difficulties, such as managing model synchronization and communication overhead. Our research indicates the trade-offs that exist in the performance of several simulation frameworks for federated learning.
Roadmap of Adversarial Machine Learning in Internet of Things-Enabled Security Systems
Authors: Harbi Yasmine , Medani Khedidja , Gherbi Chirihane , Aliouat Zibouda , Harous Saad
Published: August 2024

Machine learning (ML) represents one of the main pillars of the current digital era, specifically in modern real-world applications. The Internet of Things (IoT) technology is foundational in developing advanced intelligent systems. The convergence of ML and IoT drives significant advancements across various domains, such as making IoT-based security systems smarter and more efficient. However, ML-based IoT systems are vulnerable to lurking attacks during the training and testing phases. An adversarial attack aims to corrupt the ML model’s functionality by introducing perturbed inputs. Consequently, it can pose significant risks leading to devices’ malfunction, services’ interruption, and personal data misuse. This article examines the severity of adversarial attacks and accentuates the importance of designing secure and robust ML models in the IoT context. A comprehensive classification of adversarial machine learning (AML) is provided. Moreover, a systematic literature review of the latest research trends (from 2020 to 2024) of the intersection of AML and IoT-based security systems is presented. The results revealed the availability of various AML attack techniques, where the Fast Gradient Signed Method (FGSM) is the most employed. Several studies recommend the adversarial training technique to defend against such attacks. Finally, potential open issues and main research directions are highlighted for future consideration and enhancement.
Information Pandemic: A Critical Review of Disinformation Spread on Social Media and Its Implications for State Resilience
Authors: Surjatmodjo Dwi , Unde Andi Alimuddin , Cangara Hafied , Sonni Alem Febri
Published: August 2024

This research examines the spread of disinformation on social media platforms and its impact on state resilience through a systematic literature review of 150 peer-reviewed studies published between 2014 and 2024. The analysis revealed that disinformation spreads six times faster than accurate information, with emotions and platform algorithms playing a significant role in its spread. Factors such as low digital literacy, political polarization, and declining trust in institutions increase people’s vulnerability to disinformation. Impacts on national security include threats to the integrity of democratic processes, the erosion of social cohesion, and decreased public trust. The most effective coping strategies include improving digital literacy (78 percent effective), fact-checking (65 percent), and content regulation (59 percent). However, these efforts face ethical and legal challenges, especially regarding freedom of expression. This research highlights the need for a multidimensional approach in addressing the “information pandemic”, integrating technological, educational, and policy strategies while considering ethical implications. The findings provide a foundation for further policy development and research to protect the integrity of public information spaces and state resilience in the digital age.
Linking Diversity–Productivity Conditions of Farming Systems with the Well-Being of Agricultural Communities
Authors: Francois Jean R. , Nelson Katherine S. , Burchfield Emily K.
Published: August 2024

Agricultural diversity, productivity, and human well-being have been popular topics in recent decades, partly fueled by our quest for sustainability. However, the exact nature of the interconnections among these global priorities remains an area yet to be fully understood and explored. We contribute to this literature by examining how community well-being interacts with distinct levels of diversity and productivity in cropping systems across multiple U.S. communities. Using data at the county-level from 2010 to 2019, we first analyze how well-being varies across communities that differ in their levels of crop diversity and productivity. Then, we investigate how well-being varies across both diversity–productivity characteristics and farming intensity levels. We employ mapping techniques in conjunction with descriptive statistics to uncover and visualize patterns in well-being across contexts. Study findings show a consistent pattern of high levels of well-being across most diversity–productivity categories, with the notable exception of areas that are both highly diverse and highly productive. In addition, places with substantial commercial operations, and where agriculture contributes greatly to overall GDP and employment generally appears to have higher well-being scores compared to other places. Our analysis also reveals that there is more variability in the index of community well-being within each group than across groups of counties. Overall, the results suggest that the differences in community well-being are not solely determined by agricultural indicators, such as diversity–productivity characteristics and farming intensity levels, but also depend on contextual factors, such as social infrastructure, non-agricultural job opportunities, or local economic diversification.
Understanding Consumer Perception towards Sustainable Apparel: A Parallel Mediation Analysis on Satisfaction and Trust
Authors: Cho Heejun , Jo Donghyuk , Kim Hyojung
Published: August 2024

Many manufacturing industries today are adopting sustainable production methods in response to environmental regulations and efforts. One of the typical criteria they consider is the United Nations has set global objectives (Sustainable Development Goals: SDGs) designed to address various social, economic, and environmental challenges. “Ensuring sustainable consumption and production patterns” (Goal 12) is one of these goals. As a result, not only are manufacturers interested in sustainable products, but consumers are also showing increased interest. Consequently, the market size for sustainable products is also on the rise. This study aims to examine the mechanisms of how to improve customer loyalty of South Korean consumers who have experience purchasing sustainable apparel to vitalize the sustainable product market in Korea. Specifically, this study reveals the impact of perceived value (PV) on loyalty (LY), focusing on the mediating effects of satisfaction (SAT) and trust (TR). The analysis finds that functional value (FV), emotional value (EMV), and green value (GV) have significant direct effects on LY. Additionally, SAT and TR have significant mediating effects between PV and LY, and there is no difference in the strength of the indirect effects of SAT and TR in the relationship between FV, EMV, GV, and LY. This study extends the theoretical background of the mechanisms enhancing loyalty to sustainable apparel through the verification of parallel mediating effects. Furthermore, it is expected that these insights will serve as a direction for the operational strategies of sustainable apparel manufacturing companies.
Evaluation of Photocatalytic Hydrogen Evolution in Zr-Doped TiO2 Thin Films
Authors: Garay-Rodríguez Luis F. , Alfaro Cruz M. R. , González-Ibarra Julio , Torres-Martínez Leticia M. , Kim Jin Hyeok
Published: August 2024

Doping titanium dioxide has become a strategy for enhancing its properties and reducing its recombination issues, with the aim of increasing its efficiency in photocatalytic processes. In this context, this work studied its deposition over glass substrates using a sol–gel dip coating methodology. The effect of doping TiO2 with Zirconium cations in low molar concentrations (0.01, 0.05, 0.1%) in terms of its structural and optical properties was evaluated. The structural characterization confirmed the formation of amorphous thin films with Zr introduced into the TiO2 cell (confirmed by XPS characterization), in addition to increasing and defining the formed particles and their size slightly. These changes resulted in a decrease in the transmittance percentage and their energy band gap. Otherwise, their photocatalytic properties were evaluated in hydrogen production using ethanol as a sacrificial agent and UV irradiation. The hydrogen evolution increased as a function of the Zr doping, the sample with the largest Zr concentration (0.1% mol) being the most efficient, evolving 38.6 mmolcm−2 of this gas. Zr doping favored the formation of defects in TiO2, being responsible for this enhancement in photoactivity.
Calcium Hydroxyapatite in Its Different Forms in Skin Tissue Repair: A Literature Review
Authors: Cruel Paola Tatiana Espinosa , dos Santos Camila Pascoal Correia , Cueto Thalia Malave , Avila Lisbeth Patricia Vasquez , Buchaim Daniela Vieira , Buchaim Rogerio Leone
Published: August 2024

The skin is crucial for homeostasis and body defense, requiring quick healing to maintain internal balance. Initially used for bone repair, calcium hydroxyapatite (HAp) is now being studied for soft tissue engineering. This literature review investigated HAp’s role in tissue repair through searches on PubMed, Scopus (Elsevier), Science Direct, Springer Link, and Google Scholar databases without time restrictions, using keywords “hydroxyapatite AND skin AND wound” and “hydroxyapatite AND skin repair”. Inclusion criteria encompassed in vivo studies in humans and animals, English publications, full access, and sufficient data on HAp’s role in tissue repair. Exclusions included duplicates, unrelated articles, editor letters, reviews, comments, conference abstracts, dissertations, and theses. Out of the 472 articles initially identified, 139 met the inclusion criteria, with 21 focusing on HAp for tissue repair. Findings indicate that HAp and nano-HAp in skin regeneration are promising, especially when combined with other biomaterials, offering antimicrobial and anti-inflammatory benefits and stimulating angiogenesis. This suggests their potential application in dermatology, surgery, and dentistry, extending HAp’s versatility from hard tissues to enhancing critical properties for soft tissue repair and accelerating healing.
The Aesthetics and Pragmatics of Symmetry in High-Gain and Wideband Circularly Polarized Antenna Design
Authors: Liao Chunping , Liu Wenyong , Lin Xianjing
Published: August 2024

In this study, a high-gain broadband circularly polarized crossed dipole antenna is designed. This antenna utilizes two pairs of cross dipoles and a pair of phase delay lines to form circularly polarized radiation. Open-circuit stubs are symmetrically loaded on the four arms of these dipole pairs to introduce new circularly polarized resonating frequencies. Additionally, a symmetrically positioned rectangular ring patch is introduced directly beneath the cross dipoles to generate the third circularly polarized resonating frequency, thereby enhancing the axial ratio bandwidth of the antenna symmetrically. Furthermore, metal posts are symmetrically loaded at the four right angles of the rectangular ring patch to augment the antenna gain, maintaining the overall symmetrical balance crucial for optimal circularly polarized radiation performance. This symmetric design ensures that the antenna achieves a 3dB axial ratio bandwidth of 29.2% (1.9–2.55 GHz) and sustains a gain of 7.5 dB within the passband, showcasing excellent circularly polarized radiation attributes.
Regularization and Propagation in a Hamilton–Jacobi–Bellman-Type Equation in Infinite-Dimensional Hilbert Space
Authors: Bianca Carlo , Dogbe Christian
Published: August 2024

This paper is devoted to new propagation and regularity results for a class of first-order Hamilton–Jacobi–Bellman-type problems in a separable infinite-dimensional Hilbert space. Specifically, the related Cauchy problem is investigated by employing the Faedo–Galerkin approximation method. Under some structural assumptions, the main result is obtained by using the probabilistic representation formula of the solution in order to define the weak continuity assumptions, by assuming the existence of a symmetric positive definite Hilbert–Schmidt operator and by employing modulus continuity arguments.
Effect of Orbital Symmetry on Time–Energy Distributions of F− Ions in the Attoclock Scheme
Authors: Chen Jian-Hong , Zhao Song-Feng
Published: August 2024

The mapping relation between the emission angle of the photoelectron and its ionization time (i.e., the angle–time mapping) is important for the attoclock measurement. For a long time, the angle–time mapping was assumed to be angularly uniform. Recent investigations have demonstrated that the angle–time mapping is discontinuous for the low-energy electron at the angle for the minimum yield. However, the previous results were interpreted based on the assumption of s-electron initial states for noble-gas atoms, and the effect of the initial orbital symmetry on the angle–time mapping has been rarely investigated. In this work, we investigate the influence of the initial orbital symmetry on time–energy distribution using F− ions as a specific example. We demonstrate that the initial orbital symmetry significantly impacts the time–energy distribution. This behavior can be well explained by the saddle-point method. More interestingly, it is found that the angle–time mapping is strongly dependent on the initial orbital symmetry in the elliptically polarized laser field, especially for the low-energy electrons. Our work holds great significance for further developing the attoclock scheme.
A New Species of Brachynemurus Hagen in the B. versutus Subgroup (Neuroptera, Myrmeleontidae, Brachynemurini) from the Sonoran Province, Mexico
Authors: Marquez-López Yesenia , Chávez-Valdez Eder Leonardo , Tavares Leon Gustavo de Miranda , Contreras-Ramos Atilano
Published: August 2024

Brachynemurus bowlesi, sp. n. is a newly discovered myrmeleontid from the Sonoran Province, the northernmost subtropical region of Mexico. The new species fits within the Brachynemurus versutus subgroup, which now includes five species, all of them occurring in Mexico and the central and western United States. The new species may be identified by characteristics of the internal male genitalia, especially by a roof-like mediuncus, as well as the basal part of the 10th gonostyli, with paired processes in an acute angle and a shield-like expansion more evident in the dorsocaudal view. The formerly proposed synonymy of Brachynemurus mexicanus Banks, under B. versutus (Walker), is herein reinstated and supported.
House Sparrow Nesting Site Selection in Urban Environments: A Multivariate Approach in Mediterranean Spain
Authors: Bernat-Ponce Edgar , Gil-Delgado José A. , López-Iborra Germán M.
Published: August 2024

The House Sparrow (Passer domesticus) is a common but declining bird species in its native urban areas, partly due to reduced nesting site availability caused by modern urbanisation and loss of old architectural styles. In this study, we analysed, through a multivariate approach, the environmental factors influencing House Sparrow nest site selection in three diverse inland urban areas within the Valencian Community, Spain. We located 584 House Sparrow nests during spring 2017 and also selected 300 random points (habitat availability) in the study localities. We used Factorial Analyses of Mixed Data to assess urban feature gradients of nests and urban variables. We carried out Generalized Linear Mixed Models to compare nest locations to random points and explore variations in nesting typologies between urban zones. Specific nest site preferences vary between urban sectors, indicating that House Sparrow nests are not randomly located in urban areas. Nests are typically found near parks, schools, vacant plots, city limits, and surrounding crops, where greater vegetation cover provides abundant food sources. Low-rise terraced houses with traditional roofs and open clay tiles are consistently preferred for nesting, whereas modern architectural trends reduce nesting opportunities. Preserving green areas and old architecture with open clay tiles is essential for maintaining nesting sites and promoting House Sparrow conservation in Mediterranean urban areas. Adherence to these conservation measures may also benefit other hole-nesting species and urban wildlife reliant on green spaces.
Intranasal Delivery of Quillaja brasiliensis Saponin-Based Nanoadjuvants Improve Humoral Immune Response of Influenza Vaccine in Aged Mice
Authors: Silveira Fernando , García Florencia , García Gabriel , Chabalgoity José A. , Rossi Silvina , Baz Mariana
Published: August 2024

Increasing the effectiveness of vaccines against respiratory viruses is particularly relevant for the elderly, since they are prone to develop serious infections due to comorbidities and the senescence of the immune system. The addition of saponin-based adjuvants is an interesting strategy to increase the effectiveness of vaccines. We have previously shown that ISCOM matrices from Q. brasiliensis (IMXQB) are a safe and potent adjuvant. In this study, we evaluated the use of IMXQB as an adjuvant for the seasonal trivalent influenza vaccine (TIV) in an aged mice model. Herein, we show that subcutaneous injection of the adjuvanted vaccine promoted higher titers of IgM, IgG (and isotypes), and serum hemagglutination inhibition titers (HAI). Notably, aged mice immunized by intranasal route also produced higher IgG (and isotypes) and IgA titers up to 120 days after priming, as well as demonstrating an improvement in the HAI antibodies against the TIV. Further, experimental infected aged mice treated once with sera from adult naïve mice previously immunized with TIV-IMXQB subcutaneously successfully controlled the infection. Overall, TIV-IMXQB improved the immunogenicity compared to TIV by enhancing systemic and mucosal immunity in old mice conferring a faster recovery after the H1N1pdm09-like virus challenge. Thus, IMXQB nanoparticles may be a promising platform for next-generation viral vaccines.