bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Chimera AMP–Endolysin with Wider Spectra Against Gram-Negative Bacteria Using High-Throughput Assay
Authors: Kogawa Masato , Yoda Takuya , Matsuhashi Ayumi , Matsushita Ai , Otsuka Yoshiki , Shibagaki Shohei , Hosokawa Masahito , Tsuda Soichiro
Published: January 2025

Bacteriophage-derived endolysins are being developed as an alternative to antimicrobials. The development of endolysins against Gram-negative bacteria requires the discovery of effective endolysins against the target species and the capability to penetrate the outer membrane of bacteria by endolysin. Here, we propose an efficient endolysin development approach that combines a data-driven endolysin search utilizing bacterial genomes with high-throughput laboratory assays. As a proof of concept, we analyzed endolysin genes detected in 273 bacterial genomes of Acinetobacter, Pseudomonas, and Escherichia. Firstly, we conducted assays of 192 recombinants of endolysin genes obtained through in silico search from bacterial genomes and identified natural endolysins degrading peptidoglycan of Acinetobacter baumannii. Then, we performed high-throughput screening against Gram-negative bacteria for hundreds of chimera AMP–endolysins, natural endolysin conjugated with antimicrobial peptide. As a result, we obtained four chimera AMP–endolysins against A. baumannii, which demonstrated the minimum inhibitory concentration ranging from 4 to 8 μg/mL. Moreover, we assessed the antimicrobial spectra of these chimera AMP–endolysins, validating that two endolysins exhibited antimicrobial efficacy against Pseudomonas aeruginosa and Escherichia coli with <32 μg/mL of concentration. This endolysin development approach can be applied to other Gram-negative bacterial targets and is expected to facilitate the acquisition of effective novel endolysins.
Dynamic Immune Response Landscapes of Avian Peripheral Blood Post-Vaccination Against Infectious Bronchitis Virus Infection
Authors: Li Xuefeng , Liang Yumeng , Zhang Yu , Liu Zheyi , Cui Lu , Xi Miaomiao , Feng Shufeng , Liu Xiaoxiao , Zhu Yongxin , Liu Shengwang , Li Hai
Published: January 2025

Background/Objectives: Despite decades of extensive vaccinations against avian infectious bronchitis virus (IBV) infection, outbreaks caused by constantly emerging variants due to genome recombination between different viral strains, including vaccine strains, occur annually worldwide. The development of novel vaccines with favorable safety and effectiveness is required but is hindered by a limited understanding of vaccination against IBV. Methods: Here, we performed a comprehensive analysis of the in vivo dynamics of peripheral blood mononuclear cells (PBMCs) in specific pathogen-free chickens inoculated with the widely used live attenuated IBV vaccine strain H120 at single-cell level, using high-throughput single-cell transcriptome sequencing (scRNA-seq). Results: High-quality sequencing dataset for four scRNA-seq data containing the transcriptomes of 29,846 individual chicken PBMCs were obtained, defining 22 populations and 7 cell types based on distinct molecular signatures and known markers. Further integrative analysis constructed the time series dynamic cell transition and immune response landscapes within the two weeks post-prime vaccination against IBV. Enhanced crosstalk between antigen-presenting cells and T lymphocytes was revealed as early as four days post-vaccination. The specific immune cell populations and their comprehensive cellular and molecular networks involved in the initiation phase of antiviral adaptive immune responses were elucidated in details. Conclusions: Our study provides a comprehensive view of the dynamic initiation of immune responses in chickens against IBV infection at the cellular and molecular levels, which provides theoretical support and potential solutions for the future rational design of safe and effective vaccines, the augmentation of the efficacy of current vaccines, and the optimization of immune programs.
Harm Reduction as a Complex Adaptive System: Results from a Qualitative Structural Analysis of Services Accessed by Young Heroin Users in Mauritius
Authors: White Gareth , Luczak Susan E. , Nöstlinger Christiana
Published: January 2025

Harm Reduction (HR) was introduced in Mauritius in 2006 to mitigate the local Human Immunodeficiency Virus (HIV) epidemic mainly driven by injecting drug use. With an estimated population of 55,000 drug users and an estimated population of 6600 injecting drug users with an average of 21 years at first injection, the impact of drug use on the epidemic remains high. Those aged 15–24 years account for 20% of all new HIV cases detected annually since 2010, with known causes of incidence including both injecting drug use and unprotected sexual intercourse. Beginning with an exploration of access and barriers to needles and syringes, our study evolved to consider the dynamics between concurrent services and the effectiveness of the resulting system. Utilising snowball and purposive sampling, we conducted in-depth interviews with 27 participants, including service providers, identified by peer fieldworkers from various NGOs. Our analysis showed that HR services were connected via informal networks and displayed the same characteristics as Complex Adaptive Systems (CAS). We propose using qualitative structural analysis as a viable method to explore the complexity of HR. CAS and proper acknowledgement of peer support could guide current and future HR policy reforms.
Biyoloji Öğretiminde Kullanılmak Üzere Geliştirilen Dijital Oyunun Akademisyen, Öğretmen ve Aday Öğretmen Görüşleriyle Değerlendirmesi
Authors: Varlık Melike , Dönel Akgül Güldem , Pınar Mehmet Ali
Published: January 2025

Bu çalışma, biyoloji öğretimine yönelik bir dijital eğitsel oyunun etkisini değerlendirmeyi amaçlamaktadır. Scratch platformu kullanılarak geliştirilen oyun, biyoloji konularını eğlenceli ve anlamlı bir öğrenme ortamında sunmayı hedeflemiştir. Scratch, grafik, ses ve video gibi özellikleri destekleyen bir platform olarak öğrencilerin yaratıcı düşünme, problem çözme ve mantıksal akıl yürütme becerilerini geliştirmeye katkı sağlar. Araştırma, Erzincan Binali Yıldırım Üniversitesi'nde 5 bilgisayar eğitimi uzmanı, 5 fen eğitimcisi, 10 fen bilgisi öğretmeni ve 40 öğretmen adayıyla yürütülmüş ve ilişkisel tarama modeli kullanılarak gerçekleştirilmiştir. Katılımcılara dijital materyal sunulmuş, ardından web tabanlı eğitim materyali değerlendirme ölçeği uygulanmıştır. Katılımcıların materyal hakkındaki görüşleri, ölçeğin bir bölümüne yerleştirilen sorularla alınmıştır. Elde edilen veriler, SPSS programı kullanılarak analiz edilmiş ve katılımcıların materyal hakkındaki görüşleri betimsel analiz tekniği kullanılarak incelenmiştir. Ölçeklerden elde edilen sonuçlara göre, materyal öğretmen ve öğretmen adayları tarafından “çok iyi”, akademisyenler tarafından “iyi” olarak değerlendirilmiştir. Betimsel analiz sonuçları, materyalin anlamlı öğrenmeyi desteklediğini, karmaşık biyoloji konularını kolayca anlaşılabilir hale getirdiğini ve motivasyonu artırdığını ortaya koymuştur. Ancak geri dönüt mekanizmasının eksikliği ile daha fazla ses efekti ve animasyon eklenmesi gerektiği vurgulanmıştır. Materyal genel olarak biyoloji öğretiminde etkili bir öğrenme aracı olarak değerlendirilmiştir.
Guerres, diplomatie et thésaurisation dans l’espace égéo-anatolien. Une autre approche des relations gréco-perses au IVe siècle avant J.-C.
Authors: Hochard Pierre-Olivier
Published: January 2025

Le IVe siècle avant J.-C. est marqué par une intense activité diplomatique et militaire entre Grecs et Perses. Les affrontements directs sont rares, mais les interventions perses dans le monde égéen ne manquent pas. Toutes ont souvent été présentées de la même manière : par les subsides déversés, les Perses ont maintenu la désunion des Grecs et évité l’émergence d’un hégémôn dans les Balkans. Cette étude propose d’aborder la question des relations gréco-perses du IVe siècle par le biais de la thésaurisation, afin d’aborder d’un autre point de vue le tableau hérité des auteurs antiques.
West-Pontos black-glazed and red-figured wares: towards the end of the illusive attic supremacy ?
Authors: Dupont Pierre
Published: January 2025

A programme of XRF‑analyses performed on a selection of b.g. and r.f. fine wares from Apollonia Pontica and from some other representative West‑Pontic settlements has evidenced a far less dominant position of Attic imports than generally assumed as well as a redistribution of the other ones into several separate units. The most significant one predominantly gathers finds from the Kalfata necropolis and thus might well be ascribable to local or regional manufacture.
Hellenistic and Roman gems and jewellery from south-western Turkey
Authors: Lafli Ergün , Henig Martin
Published: January 2025

In this paper, 19 Hellenistic and Roman engraved gemstones are discussed, all of which are in the collections of local museums at Aydın and Marmaris in south‑western Turkey. They are significant, as very few gemstones have been published from southern Ionia and from the whole of Caria. Following the listing of the gems in Aydın, the next section describes six gold finger rings and earrings with plain gem or glass settings, as well as a ring which has lost its gem. In addition, a rock‑crystal cabochon, probably of Roman date, from Aydın is illustrated. The final two parts of the paper describe two forgeries and then the bezel of a finger‑ring and a clay bulla, both of which are of Hellenistic date.
Alexandre émule d’Achille dans les Histoires d’Alexandre le Grand de Quinte‑Curce : modalités et enjeux d’un exemplum mythique dans un discours sur le pouvoir monarchique
Authors: Pérez Claire
Published: January 2025

Cet article étudie la manière dont l’historien romain Quinte-Curce s’est approprié le motif de l’imitation d’Achille par Alexandre le Grand, dans une oeuvre qui porte un discours sur la royauté à vocation exemplaire. Les mentions explicites d’Achille étant toutes utilisées dans les discours que l’historien prête à Alexandre, Quinte-Curce fait s’intégrer l’exemplum homérique dans la rhétorique du pouvoir de son personnage, qui vise à construire son mythe héroïque. Cependant, le personnage se réfère à Achille lors d’épisodes où l’historien dénonce sa faillite morale et ses passions. Pour affiner son portrait du roi, Quinte-Curce fait usage d’une technique de caractérisation qui mobilise la polyphonie du texte historique et l’intertexte poétique. Par ce biais, il appuie sa condamnation d’Alexandre en le représentant en pâle reflet et mauvais utilisateur du modèle héroïque.
Les traces d’une cosmogonie orphique chez Silius Italicus ? (Punica, XI, 440-480)
Authors: Voisin Corentin
Published: January 2025

Dans le livre XI des Punica, Silius Italicus met en scène la performance de l’aède de Cumes Teuthras qui expose dans un deuxième chant les exploits des grands lyricines antérieurs en concluant par Chiron et Orphée. Cependant, le centaure se voit prêter un poème cosmogonique très abrégé qui conviendrait mieux à Orphée au regard du reste de la littérature antique. Ce récit des origines pourrait s’apparenter à un fragment orphique prêté à Chiron, identifié probablement au maître d’Orphée, afin d’en rehausser encore l’ancienneté et l’autorité.
El supuesto fragmento de Fabio Píctor transmitido por Arnobio: una propuesta
Authors: Martinez-Pinna Jorge
Published: January 2025

Dans son récit sur une tête trouvée au Capitole, Arnobe l’identifie à celle d’Aulus de Vulci et il cite parmi ses sources un certain Fabius, habituellement identifié comme Fabius Pictor. Cet article tente de montrer qu’une telle identification est improbable et de proposer une alternative : Fabius Rusticus serait la source.
Uso da prototipagem em reconstrução de assoalho orbitário em sequela de fratura blow-out: relato de caso
Authors: Gregório João Anderval , Sá Rodrigo Tavares de , Brasil Richard Presley Silva Lima , Sobrinho Luiz Carlos Pires , Sousa Matheus Fernando Campos de , Carrero Pérola de Castro , Belle Júlia Ribeiro Lima , Vilela Thiago Freitas Prado
Published: January 2025

Fraturas orbitais do tipo blow-out tem ganhado espaço no planejamento tecnológico. A modernidade trouxe consigo exames de imagens tridimensionais para melhor visualização e a partir desses exames a criação dos modelos de prototipagens rápidas, modelo 3D, facilitando o planejamento e a execução. Este trabalho tem como objetivo relatar um caso de um paciente de 48 anos, sexo masculino, vitima de um acidente motociclistico, com diagnóstico de fratura orbital do tipo blow-out, seu tratamento cirúrgico e a importância da utilização dos modelos 3D’s no planejamento. O exame de imagem tridimensional (tomografia computadorizada) mostrou uma fratura do tipo blow-out na região, afetando o assoalho da cavidade ocular esquerda. Seu tratamento foi feito com acesso cirúrgico subtarsal, sob anestesia geral. Foi feita a fixação da tela de titânio de 1,5 mm na margem infraorbitária, com tela de titânio pré-moldada com auxílio do modelo impresso da órbita sequelada. A utilização de modelos de prototipagens rápidas torna cada procedimento personalizado, aumentando a capacidade de se obter um tratamento satisfatório, reduzindo risco de intercorrências, reoperações e de complicações após a cirurgia.
Internação por quadro respiratório de uma paciente usuária de cigarro eletrônico na cidade de Lages – SC: um relato de caso
Authors: Nogueira Tiago da Cruz , Fernandes Matheus Guanabara , Nedel Vitor Luís
Published: January 2025

Os dispositivos eletrônicos de fumar (DEF) se popularizaram mundialmente nos últimos anos devido sua associação com a cessação do tabagismo convencional, entretanto seu uso trouxe um novo problema para saúde pública, a lesão pulmonar associada ao uso de cigarros eletrônicos (EVALI). O objetivo é relatar o caso de uma paciente com a doença, apresentando seu quadro clinico, tratamento e evolução clínica. Se tratando de uma doença descoberta recentemente, seu diagnóstico, tratamento e prognostico ainda não estão bem elucidados, contudo até o momento o fator que apresenta efetividade na melhora clínica e prevenção da doença é a não utilização do DEF.
Taxonomic Revision and Conservation Status of the Species of Eryngium (Apiaceae, Saniculoideae) Native to Australia
Authors: Padin Ariana Lucía
Published: January 2025

The “Pacific” clade of Eryngium L. is a group comprising ca. 40 species that grow in Australia, Chile, the western United States, and east-central South America. Taxonomic studies of the American lineages of this clade have recently been published. However, the Australian species of Eryngium have not been taxonomically revised for more than a century. The objective of this study was a taxonomic revision of the Eryngium species native to Australia, including an analysis of their conservation status. For this, the morphology, geographic distribution, and habitat of ca. 550 herbarium specimens were analyzed. In addition, the conservation status of each species was informally evaluated following the IUCN Red List categories and criteria of the International Union for Conservation of Nature. In total, nine Eryngium species native to Australia are recognized, eight of which are endemic. A key for the recognition of these species is provided. For each species, a list of accepted synonyms, a morphological description, an illustration, a distribution map, and a discussion of habitats are presented. Two new synonyms are proposed, a new combination is presented, and nomenclatural problems are analyzed and resolved, including the typification of seven names. The morphological analyses of this study show that the majority of Eryngium species from Australia are heterophyllous. This characteristic had been reported previously for only two Australian Eryngium species. Two of the nine Australian species of Eryngium were found to be in a threatened category.
A Key to the Neotropical Genera of Lauraceae
Authors: Alves Flávio Macedo , Assis Leandro Cézanne de Souza , Quinet Alexandre , Baitello† João Batista
Published: January 2025

Lauraceae are a diverse family of the Neotropical flora that have recently undergone extensive taxonomic changes in the delimitation of genera. Here we review 30 currently accepted Neotropical genera of Lauraceae based on the combination of vegetative and reproductive characters, with a focus on floral characters. We present an identification key, as well as diagnostic descriptions, number of species, distribution, and phylogenetic information for the accepted Neotropical genera.
Los sistemas de información geográfica como recurso didáctico en enseñanzas de arquitectura y urbanismo. Iniciación al QGIS. 6) Creación capas vectoriales
Authors: Maruri Arana Ainhoa , Rodríguez Lora Juan Andrés , Navarro de Pablos Francisco Javier , López Bravo Celia , Ostos Prieto Francisco Javier , Molina Liñán María Mercedes , del Espino Hidalgo Blanca , Mosquera Adell Eduardo , Pérez Cano María Teresa , Navas Carrillo Daniel , Mosquera Pérez Clara Teresa
Published: January 2025

Los Sistemas de Información Geográfica (SIG) son un conjunto de herramientas que integran y relacionan diversos componentes, además de organizar, almacenar, manipular, analizar y modelizar grandes cantidades de datos geográficamente referenciados. De este modo, permiten incorporar datos espaciales vinculados al mundo real e incorporar aspectos sociales, culturales, económicos y ambientales que llevan a tomar decisiones de una manera más eficaz.

En este sentido, el estudiantado de estudios relacionados con la arquitectura o el urbanismo podrían, gracias a las herramientas SIG, crear consultas interactivas, analizar la información espacial, editar los datos, proponer mapas y planos, así como, representar gráficamente todos los resultados. En consecuencia, permitiría trabajar con bases de datos y hacer análisis complejos, aplicados a diversos campos de gran escala como la topografía y el relieve, la hidrografía o las redes de infraestructuras, entre otros, para los procesos de planificación del territorio y la ciudad, ya que proporcionan el manejo de grandes volúmenes de información gráfica y descriptiva.

Actualmente, en el Grado en Fundamentos de Arquitectura no hay asignaturas regladas específicas que ofrezcan enseñanzas de SIG, sino que son ciertos grupos de asignaturas concretas y por voluntad propia del profesorado que destinan parte de su docencia a la presentación de esta herramienta. Esto supone una enseñanza desigual entre el alumnado, ya que en algunos casos pueden llegar a finalizar sus estudios de grado sin haber recibido formación de la misma, siendo imprescindible actualmente en numerosos ámbitos del mundo laboral.

Por tanto, esta propuesta ha realizado una serie de vídeos didácticos que introduzcan al estudiantado en un manejo básico del software QGIS. Entre las herramientas SIG disponibles, QGIS resulta de especial interés por tratarse de una aplicación libre y de código abierto, en actualización constante y de fácil manejo, cuestión que propicia que tanto el estudiantado actual como el egresado pueda tener acceso con facilidad.

Así, con los diez vídeos didácticos lo que se ha buscado es exponer algunas cuestiones concretas de aplicación de QGIS a los estudios de arquitectura y urbanismo. En consecuencia, se han empleado las aplicaciones propias del SAV como Camtasia o Flashback-pro para grabación de pantalla del ordenador y, posteriormente, en el montaje se ha introducido a través de IA una breve introducción a los vídeos y la voz con las instrucciones de los mismos. Se ha buscado que las grabaciones didácticas no sean muy extensas, por lo que tienen una duración aproximada de 5 minutos y cada uno hace referencia a un tema en concreto.
UMA REVISÃO DE LITERATURA: ABORDAGEM DAS PESSOAS VIVENDO COM HIV NA APS A PARTIR DE UMA REVISÃO DA LITERATURA
Authors: André Freitas Barbosa Dyego
Published: January 2025

Quatro décadas após o surgimento da Aids, ainda é perceptível que algumas pessoas sofram vulnerabilidade em decorrência do HIV/Aids. A vulnerabilidades geralmente vem entrelaçada com a pobreza, é ela o principal fator de exclusão social desses pacientes. O quanto atendimento a esses pacientes a Atenção Primária à Saúde (APS) está fundamentada na atenção primária à saúde, orientando e buscando manter equidade e solidariedade social. O objetivo do trabalho é analisar como são feitas as abordagens das pessoas vivendo com HIV na APS. A pesquisa apresentada é uma revisão de literatura, o qual analisou 15 artigos publicados entre 2006 e 2023, nas bases da SciELO, google acadêmico, Ciência & Saúde, Capes, ciência e saúde. Foram analisadas quais abordagens utilizadas pelas unidades de atenção básica em saúde UBS aos pacientes soro positivos, quais dificuldades encontradas, e como é feito o atendimento. A pesquisa utilizasse de uma metodologia integrativa, o qual permite a análise das práticas empregadas de acordo com os artigos estudados. O estudo julga a necessidade de apoio a tais estruturas, concluindo que é necessário que as APS possuam melhores estruturas, melhor apoio por parte dos governantes para que todos os envolvidos exerçam suas obrigações, e dessa forma busquem fortalecer a gestão compartilhada, efetivando práticas democráticas, coletivas e participativas.

Palavras-chave: Atenção Primária à Saúde; HIV; Pacientes; Ciência;
C Language Classroom Reform Exploration Based On Learning Community Teaching Concept
Authors: DepengXu DepengXu , YanyingZou YanyingZou , Fen Yi Fen Yi , Qing Lu Qing Lu , Mengshan Li Mengshan Li
Published: January 2025

The learning of C language course is
the basis for the subsequent learning of other
professional courses for computer majors. C
language is a course with strong logic, strong
operability, many knowledge points and difficulty,
so the teaching of this course is a difficult point
.The reform of traditional C language classroom
teaching combined with the "learning community"
concept teaching can stimulate students' interest in
learning, promote students' practical ability, and
reduce the difficulty of teaching.
Entrepreneurship Orientation, Market Orientation On Business Performance; Study At Small And Medium Enterprise Food industry In Kendari ".
Authors: Nofal Nur Nofal Nur , Conny Conny
Published: January 2025

This study purpose was to measure
and analyzing effect of Entrepreneurship
Orientation, Market Orientation on Business
Performance at Food industry Small and Medium
Enterprises (SMEs) in Kendari. Research objects
are Food industry SMEs in Kendari. This study
uses primary data. Total population is 244 food
industry SMEs. Sampling technique is census
method. Data analysis is Multiple Regression
Analysis. Research results show that: Orientation
Entrepreneurship and Market Orientation and
business performance can affect business
performance. Orientation Entrepreneurship can
affect business performan, Market Orientation can
improve business performance
An Adaptive Mixed Finite Element Method for Second Order Elliptic Eigenvalue Problems
Authors: Xiaomin Cai Xiaomin Cai , Qiuxia Tian Qiuxia Tian , Shan Nie Shan Nie
Published: January 2025

This paper studies the Raviart-Thomas mixed finite element method for solving the general
second-order elliptic eigenvalue problem. It derives and analyzes a class of stable residual-type posterior error
estimators, and through theoretical analysis, proves the effectiveness and reliability of the proposed posterior
error indicators. Based on the posterior error estimate in this paper, we develop an adaptive algorithm to solve
the second-order elliptic eigenvalue problem, and the numerical results demonstrate that the adaptive algorithm
established in this paper is efficient.
Dynamics Cardiovascular Diseases Immune System; Mathematical Modeling
Authors: Annia Ruiz Sánches Annia Ruiz Sánches , Luis Eugenio Valdés García Luis Eugenio Valdés García , Priscila Soares Dos Santos Priscila Soares Dos Santos , Sandy Sánchez Domínguez Sandy Sánchez Domínguez , Adolfo Fernández García Adolfo Fernández García
Published: January 2025

In this work, investigations were carried out in relation to the cardiovascular system, the main diseases that affected it, the situation that exists worldwide, in the Americas, in Brazil and Cuba in relation to
these diseases; in addition, existing statistics regarding mortality due to these diseases in the indicated countries and regions are researched. A model is developed, through a system of differential equations, where it is
assumed that the patient has or does not have the presence of thrombi and/or atheromatous plaques; for the
case in which there are no disturbances in the process, this system has two equilibrium positions, the trajectories of the system are studied in the vicinity of the equilibrium positions and conclusions are drawn for both
cases in correspondence with the magnitudes treated in the process; Examples are given for each of the situations presented and it is verified that the system trajectory graphs correspond to the theoretically demonstrated
results
A Comparative Study of Gender Marking System In Biate And Thadou
Authors: Tariang Lorina D , Kim Haokip Dr. D Mary
Published: January 2025

The aim of the paper is to present a comparative study of gender marking system in Biate (ISO 639-3:biu) and Thadou (ISO 639-3:TCZ), two Kuki-Chin languages spoken in North east India. Biate is an endangered language spoken in the Southern Jaintia Hills, Meghalaya and western Dima Hasao, Assam by 19,000 speakers (Ethnologue 2019). Thadou is also a Kuki-Chin language spoken mainly in the North-Eastern part of India including Manipur, Nagaland, Assam and some parts of Myanmar by 1,90,595 speakers according to 2011 census of India. In both these languages, gender is marked with only the animate nouns. Gender is only a lexical feature in the two languages. They do not have grammatical gender. For example, in Biate, gender distinction for human beings is made by adding /pa/ for ‘masculine’ and /pui/ or /nu/ or /ni/ for ‘feminine’. In Thadou,in the case of nouns having generic names, male and female are indicated by the suffix -pa and -nu respectively. In other words, the suffix -nu indicates female while -pa indicates male. This paper aims to investigate the nature of gender marking in both the languages, their role in showing grammatical relationships and different strategies applied in finding the gender markers for the masculine and feminine genders of the two languages.
Job roles, Workforce requirements and Entrepreneurial opportunities in the Sector of Insurance
Authors: Sumi.S Sumi.S , Prof.A.Vimala Prof.A.Vimala
Published: January 2025

The study explores industry-specific career and entrepreneurial opportunities in India, with a special focus on the insurance sector. It aims to identify diverse employment opportunities within the industry, categorize them based on educational qualifications, and assess students' awareness of these prospects. The proposed sample of the study is 350 participants, and it is s purposive sampling. This study seeks to bridge the knowledge gap by shedding light on the varied career paths in the industry, helping students and job seekers make informed decisions, and ultimately contributing to reducing unemployment by tapping into the growing opportunities in the insurance sector.
Energy efficient technologies in food production: examples and implementation
Authors: Ishchenko S. M. , Slinchak M. D.
Published: January 2025

Energy-efficient technologies are a key factor in ensuring the sustainable development of the food industry. With rising energy costs and increasing environmental regulations, the implementation of energy-efficient solutions is becoming a necessity for the industry. This article examines the main energy-efficient technologies that can be applied in food production, such as induction heating, heat pumps, and energy recovery systems. Examples of the implementation of these technologies at Ukrainian enterprises, such as the companies “Roshen”, “Galychyna”, and “Myronivsky Hliboproduct”, demonstrate their effectiveness in reducing energy consumption and increasing productivity. Specifically, the introduction of induction ovens at Roshen factories has reduced energy consumption by 15 %, and the installation of heat pumps at the Galychyna dairy plant has reduced energy costs by 20 %. An analysis of the literature shows that modern scientific research actively supports the need to transition to energy-efficient technologies in the food industry.
The implementation of energy-efficient technologies not only reduces energy costs but also helps reduce greenhouse gas emissions, positively impacting the environment. For the successful adaptation of Western technologies to Ukrainian conditions, it is necessary to intensify scientific research and support innovative projects in this area.
In today’s world, where energy is becoming increasingly expensive and environmental challenges require urgent solutions, the issue of energy efficiency is becoming extremely relevant. This is especially true for the food industry, which is one of the largest energy consumers. The use of energy-efficient technologies in food production not only reduces energy costs but also helps to reduce greenhouse gas emissions, which has a positive impact on the environment.
SYNTHESIS AND CHARACTERIZATION OF NEW POLYMERIC COATINGS FROM ANTHOCYANIN DYE AND STUDY BIOLOGICAL ACTIVITY
Authors: Mayson Thafir Hadi  , Zainab A. Jabarah  , Sana H. Awad
Published: January 2025

This study was aimed to prepared new polymeric coverings reinforced by the naturally occurring pigment anthocyanins and investigate their biological efficacy when combined with certain drugs against specific kinds of microbe’s pathogens. FT-IR spectroscopy and mass spectrometry (MS) were used to identify the active groups of the anthocyanin pigment, which were situated the functional groups of anthocyanin in contrast to crystalline compounds, X-ray diffraction (XRD) examination also revealed the production of irregularly constituted compounds. Furthermore, all derivative compounds were had high inhibitory activity against the Gram-positive bacteria Staphylococcus aureus, as well as against the fungus Candida albicans in different concentrations.
OPTIMAL CONDITIONS FOR EXTRACTION PHENOLIC COMPOUNDS AND FLAVONOIDS FROM MILLET BRAN AND STUDYING SOME OF THEIR BIOLOGICAL ACTIVITY
Authors: Mariem M. A.AL-Abas  , Jassem. M. Nasser
Published: January 2025

The aim of this research is to determine the optimal conditions for extracting phenols and flavonoids from the bran of Iraqi proso millet and Ukrainian foxtail millet, whole and defatted, and  studying some of their biological characteristics. Petroleum ether, methyl alcohol (60% and 80%), distilled water, and ethyl alcohol at concentrations of 60, 80, 90, and 99% were used as extraction solutions. The flavonoid content was estimated using the Rutin standard curve, and the phenolic content was determined using the Folin-Ciocateau method based on the gallic acid standard curve. The results showed that the concentration of phenolic compounds and flavonoids in proso millet bran extracts were (770.56, 865.38, 1059.94, 883.16, 722.17, 726.12, 587.79, 400.69) µg/g and (188.26, 196.26, 353.60, 671.38, 96.94, 93.60, 117.60, 300.60) µg /g, respectively, and in Ukrainian millet bran extracts (889.08, 1034.80, 1182.00, 1331.17, 1008.19, 990.42, 592.85, 581.43) µg /g and (302.94, 484.26, 758.94, 940.32, 188.26, 97.60, 217.60, 554.94) µg/g respectively. The highest phenolic and flavonoids compounds concentrations were achieved when ethyl alcohol (99%) as extraction solution was used for Ukrainian millet. Therefore, this treatment was adopted in conducting the free radical scavenging test, at different concentrations (0.125, 0.250, 0.500, 0.750, 0.800) mg/ml, as RSA were (24.68, 40.18, 67.56, 81.98, 89.55%), respectively, compared to ascorbic acid at the same concentrations, which were (40.14, 57.34, 73.46, 89.93, 99.55%).
STUDY OF Bacillus licheniformis BACTERIA AS A BIO-CONTROL AGENT IN REDUCING AFLATOXIN B1 TOXICITY IN DRIED GRAPE SAMPLES
Authors: H. Z. Hussein  , E. K. Abdul-Karim  , M. I. Alghannoum
Published: January 2025

This study was aimed to isolate and identify fungi contaminating raisin samples and evaluate the effectiveness of bacteria in inhibiting fungal growth and reducing toxin levels. The isolation results the fungus A. flavus was the most frequent and appeared in the samples, reaching 54.5 and 44.4%, respectively. The results showed that all isolates of A. flavus had the ability to produce aflatoxin B1, as confirmed by the ammonia vapor test. The isolate with the highest toxin production was identified through nucleotide sequences deposited in the World Genomic Organization's Gene Bank under accession number OR192858. The results demonstrated the ability of the live bacteria Bacillus licheniformis to inhibit fungal growth, reaching 94.4%, compared to 72.56% for the killed bacterial filtrate. The toxin concentration was 62.11 ppb in the toxin-producing isolate treated with bacteria, while it was 285.866 ppb in the toxin-producing isolate without bacteria. An 85.65% reduction in toxin levels was observed compared to the control, which registered 0%, with a toxin concentration of 41.08 ppb in the bacteria-treated toxin-producing isolate, while it was 285.866 ppb in the untreated toxin-producing isolate.
Phytochemicals as Cancer Immunotherapeutics: Bridging Natural Compounds and Advanced Treatment Strategies
Authors: Akhtar Urva , Saleem Mahnoor , Shahid Aimun , Usman Nimra , Usman Zunaira , Khan Seemrose , Hayat Rabia , Haider Sameea , Rasheed Waqas
Published: January 2025

This article explores the potential of phytochemicals as immunomodulatory agents in cancer therapy, bridging the gap between traditional plant-based medicine and modern oncological treatments. Phytochemicals, including flavonoids, alkaloids, terpenoids, and polyphenols, have demonstrated significant immunomodulatory properties that can enhance immune system function and promote anti-tumor responses. These bioactive compounds work by modulating key signaling pathways, including immune cell activation, cytokine production, and tumor microenvironment interactions. Despite their promising therapeutic potential, challenges remain in optimizing their bioavailability and therapeutic efficacy. This review highlights the latest advances in the use of phytochemicals for cancer immunotherapy, discussing their mechanisms of action, clinical applications, and the need for further research to fully harness their potential in combination with existing cancer treatments. Integrating these natural compounds into modern cancer therapy could provide novel, effective and less toxic treatment options for cancer patients.
Interactions between Monetary and Budgetary Policies in the CEMAC Zone
Authors: manou Soule , Dessy-Karl Tadadjeu
Published: January 2025

The aim of this article is to analyse the impact of fiscal policy on the general price level in the CEMAC zone in a context of increasing of growing debt and budget deficits. In particular, it aims to study the effects of public deficit and debt on inflation. In using data from the 06 CEMAC countries covering the period 1990-2020, we have highlighted the budgetary theory of price levels. The results of the econometric estimates obtained using the Feasible Generalized methods show that the budget deficit and public (and external) debt (and external) debt have positive and significant effects on inflation. Furthermore, the results show that external public debt is more inflationary than inflationary than domestic public debt in this Zone.
Działalność polityczno-patriotyczna nauczycieli polskich wiejskich szkół ludowych w Galicji w okresie autonomii (1867–1918)
Authors: Pelczar Roman
Published: January 2025

Celem artykułu jest ukazanie środowiska nauczycieli pracujących w szkołach elementarnych (ludowych) w polskich wsiach w czasach autonomii (trwającej od połowy lat 60. XIX w. do 1918 r.). Artykuł powstał na zróżnicowanej i obszernej bazie, którą tworzą źródła archiwalne i drukowane, pamiętniki oraz tematyczna literatura. Przedmiotem szczegółowych analiz stała się działalność polityczna i patriotyczna nauczycieli, którzy współtworzyli wiejskie środowiska inteligenckie, wtedy jeszcze bardzo nieliczne. Pozytywnymi przejawami obecności nauczycieli na wsi (oprócz działalności oświatowej) było ich angażowanie się w lokalne życie społeczne i polityczne. Analiza materiału źródłowego wskazuje, iż podejmowali oni różne działania o charakterze politycznym i patriotycznym. W artykule zwrócono uwagę na różne uwarunkowania wpływające na te działania. Utrudniały ją austriackie władze centralne oraz Galicji, które nie pozwalały nauczycielom prowadzić antypaństwowej działalności politycznej i patriotycznej. Jednak duża część nauczycieli nie podporządkowała się tym nakazom. Starała się wychowywać swych uczniów na Polaków i patriotów. Poza tym włączała się w edukację polityczną osób dorosłych. Należała też do różnych partii politycznych. Nauczyciele angażowali się także w różne działania polityczne i wojskowe w czasie I wojny światowej.
THE IMPACT OF PERFORMANCE MANAGEMENT SYSTEM ON PRODUCTIVITY WITHIN SOUTH AFRICAN SOCIAL SECURITY AGENCY IN VHEMBE DISTRICT, 2021-2023
Authors: Mutshinyalo Magoro  , Dr.H.Hakweenda
Published: January 2025

This study examines the impact of the performance management system on employee productivity at the South African Social Security Agency (SASSA) in the Vhembe district. The objectives include identifying and explaining various approaches to implementing a performance management system, investigating its effects on employee productivity, and exploring alternative methods to enhance employee performance and productivity. A qualitative research approach was used, involving 24 respondents selected through purposive and random sampling techniques. The findings reveal that poor communication, lack of training, and insufficient resources significantly hinder productivity, even when a performance management system is in place. The study concludes that enhancing communication, providing targeted training, and ensuring adequate resources can improve the performance management system and boost productivity among SASSA employees. Recommendations emphasize adopting a systematic approach to promote effective and responsive service delivery within the agency.
KEYWORDS: Performance Management System, Productivity, Employee Performance and Service Delivery.
137Cs MIGRATION ACTIVITY IN THE LINK “SOIL – PLANT” IN THE KRASNOYARSK REGION CENTRAL AREAS AGRARIAN LANDSCAPE
Authors: Fedotova Arina
Published: January 2025

The purpose of the study is to assess the intensity of 137Cs migration in the “soil-plant” link in the central areas of the Krasnoyarsk Region in agricultural landscapes with additional radiation load; to establish the accumulation coefficient of 137Cs for soils of agricultural landscapes of the forest-steppe zone of the Krasnoyarsk Region; to assess the correlation between the content of 137Cs in soils and feeds, describe the identified dependence using linear regression equations. An extensive literature review is provided on the characteristics of the migration activity of 137Cs from various types of soils into plants in agrobiocenoses contaminated as a result of radiation accidents. The author, based on a radioecological survey of the territory of the central areas of the region, identified agricultural landscapes with anthropogenic pollution. Data on the specific activity of 137Cs in soils and feed produced in agricultural landscapes with additional technogenic load are presented. The ambient dose equivalent rate (ADR) in the tested agricultural landscapes corresponds to the value characteristic of the territory of the Krasnoyarsk Region. The specific activity of 137Cs in soils of agricultural landscapes with doses of 1.33 and 1.55 mGy/year exceeds the average for the Krasnoyarsk Region. The specific activity of 137Cs in feed of agricultural landscapes with absorbed doses of 1.33 and 1.55 mGy/year does not exceed the values of control levels; accordingly, radiation-safe feed is produced in the Krasnoyarsk Region. The accumulation coefficient of 137Cs for the “soil-plant” link for agricultural landscapes with absorbed doses of 1.33 and 1.55 mGy/year is 0.02, which indicates the availability of only 2 % of soil 137Cs during its migration into plants. In the tested agricultural landscapes, a linear correlation was determined between the specific activity of 137Cs in soils and feeds. A linear dependence of the 137Cs content in forb hay on the 137Cs concentration in soils was revealed; on this basis, linear regression equations were derived that make it possible to determine the radiation safety of feed based on 137Cs at a certain 137Cs concentration in soils.
TECHNOLOGICAL OPERATIONS INFLUENCE ON THE COMPOSITION OF CATIONS IN TYPE PORT LIQUEUR WINES FROM THE PLATOVSKY GRAPE VARIETY
Authors: Kalmykova Elena , Kalmykova Natal'ya , Gaponova Tat'yana
Published: January 2025

The purpose of the study is to establish the influence of grape processing technology, as well as the heat treatment process of wine materials on the cationic composition of liqueur wines such as port made from the Platovsky grape variety. Objectives: to analyze the composition of cations in liqueur wines such as port, obtained from the Platovsky grape variety, during their preparation. The study was carried out on the basis of the laboratory for quality control of grape and wine products of ARRIV&W, a branch of FSBSI FRASC. Test samples were prepared from a white technical grape variety of interspecific origin, bred by ARRIV&W, a branch of FSBSI FRASC – Platovsky.Wine materials were prepared according to the following technological schemes: infusion of the must on pulp with the addition of the enzyme preparation depectylclarification for 8–10 hours; infusing the wort on the pulp for 36 hours at ambient temperature, followed by pressing the pulp and fermenting the wort to a residual sugar of 100–120 g/dm3. As a control, wine material prepared by fermentation of must on the mash of Aligote variety was taken. It was found that an increase in potassium concentration is facilitated by such operations as fermentation (Aligote (control) – 1200 mg/dm3) and infusion (Platovsky B2 – 690 mg/dm3) of wort on pulp; calcium is increased by treating the pulp with enzyme preparations (Platovsky B1 – 130 mg/dm3). The amount of sodium does not depend on the technological operations performed. The lowest potassium content was established in the Platovsky B1 experiment (490 mg/dm3). An increase in the concentration of magnesium is facilitated by such operations as treating the pulp with enzyme preparations, since its highest value was noted in the Platovsky B1 experiment (260 mg/dm3). After heat treatment of wine materials, a decrease in the concentration of potassium and calcium was observed in all test samples of wine, as well as a decrease in the concentration of magnesium in the Platovsky B1 samples and the control Aligote.
Wściekłość i wrzask. Studium recepcji „Ładunku 200” Aleksieja Bałabanowa
Authors: Gorlewska Paulina
Published: January 2025

Przedmiotem artykułu jest analiza rosyjskiej recepcji Ładunku 200 (Gruz 200, reż. Aleksiej Bałabanow, 2007), która miała miejsce tuż po premierze utworu. Ocena filmu jako utworu artystycznego oraz prawdziwości zawartego w nim obrazu Rosji podzieliła zarówno krytyków, jak i zwykłych odbiorców, stając się tematem debaty społecznej. Analityczna część tekstu, dotycząca interpretacji krytycznych dzieła, jest oparta na historyczno-materialistycznej metodzie badania odbioru utworów filmowych opracowanej przez Janet Staiger. Punktem odniesienia jest w niej ideologia dominująca w polityce historycznej ówczesnej Rosji oraz w klasycznych regułach narracji. Do analizy afektywnych doświadczeń odbiorczych została użyta teoria psychoanalityczna.
Dzieciństwo i trauma – obraz młodego pokolenia Japończyków w kinie współczesnym
Authors: Loska Krzysztof
Published: January 2025

Tematem artykułu jest analiza wizerunku młodego pokolenia we współczesnym filmie japońskim, ze szczególnym uwzględnieniem traumatycznych przeżyć z okresu dzieciństwa lub wczesnej młodości. Autor wychodzi z założenia, że w dyskursie humanistycznym trauma przestaje być pojęciem klinicznym, staje się narzędziem interpretacji kultury, uświadamia nam charakter naszego stosunku do czasu minionego oraz wskazuje na problematyczność samego przedstawiania. W rozumieniu traumy Loska wychodzi od propozycji teoretycznych Dominicka LaCapry i Cathy Caruth, którzy zwracają uwagę na narracyjny wymiar tego pojęcia. Fikcja – jak zauważa LaCapra – jest w stanie analizować to, co traumatyczne, szczególnie w niedawnej przeszłości, w tym fragmentację, pustkę czy zanik doświadczenia, i może stawiać pytania o inne możliwe formy doświadczenia. Może również analizować w szczególnie przekonujący i niepokojący sposób afektywny czy emocjonalny aspekt doświadczenia i rozumienia. Przedmiotem analizy są filmy współczesnych reżyserów japońskich – Shinjiego Aoyamy, Masato Harady, Hideaki Anno, Akihiko Shioty, Eijiego Okudy, Toshiaki Toyody, Hirokazu Koreedy – opowiadające o kryzysie tożsamości, alienacji, zaburzeniach osobowości, a przede wszystkim o urazach psychicznych, które uniemożliwiają prawidłowe funkcjonowanie w społeczeństwie.
Czas dzieciństwa i dojrzewania. Dwie epoki heroiczne w „Sanatorium pod Klepsydrą”
Authors: Jakubowska Małgorzata
Published: January 2025

Sanatorium pod Klepsydrą (1973) Wojciecha Jerzego Hasa opowiada o powrocie do dzieciństwa i wieku nastoletniego, nie jest jednak historią utkaną z tradycyjnie rozumianych wspomnień. To film o wyprawie w głąb czasu. Dla Brunona Schulza, autora pierwowzoru, dojrzewanie do dzieciństwa jest egzystencjalnym zadaniem dla każdego człowieka. I chociaż postulat ten brzmi jak element psychoanalitycznej terapii, nie otrzymujemy powierzchownego freudyzmu ani w prozie Schulza, ani w filmie Hasa. Freud chciał uwolnić swego pacjenta od ciężaru dzieciństwa i zaoferować wolność w teraźniejszości po uporaniu się z traumą wczesnych doświadczeń. Natomiast w wizji Schulza dominuje pragnienie powrotu do czasu przeszłego, ponieważ tylko tam możemy odnaleźć wolność – dziecięcą, niczym nieskrępowaną twórczość. W Sanatorium pod Klepsydrą wokół figur rodzicielskich nie tylko krystalizuje się ludzka osobowość, ale zostaje ujawniona filozofia czasu. Has powtarza za Schulzem, że śmierć i narodziny to dwie strony życia, podobnie jak figury Matki i Ojca. Grób i łono są źródłami czasu, stamtąd wszystko wypływa i tam powraca. Żadna miłość nie jest pierwsza, a żadna śmierć ostateczna.
Climate-Smart Agriculture and Poverty Reduction in Ejisu-Juaben Municipality of Ghana
Authors: Sandow Baba , Issaka Amadu , Appiah Divine Odame
Published: January 2025

Climate change has emerged as a worldwide development issue affecting many sectors of the global economy, especially agriculture. Expected effects of climate change on agriculture, food security, and poverty are raising global concerns. The increase in agricultural production over the past years has been due to land area expansion with very little change in production strategies. Agriculture is the most important economic sector of Ghana, and central to the survival of most people, especially in Ejisu-Juaben Municipality where agriculture is the mainstay of most inhabitants. However, crop cultivation in the municipality is primarily subsistence and rain-fed, but changing climate affects harvest and food production. For sustainable food security, and for agriculture to feed the world in a way that can ensure sustainable rural development, it must become ‘climate-smart’. This, therefore led the researcher to assess the farmers’ adaptation strategies used for climate change and to assess the climate-smart on-farm land-use and water management strategies that can be adopted by smallholder farmers in the Ejisu-Juaben Municipality. Attention would be given to farmers’ climate-smart adaptation strategies and poverty reduction linkages in the municipality. The mixed approach was employed and a sample of 406 respondents was used. Mixed sampling techniques comprising stratified and multi-stage sampling methods were employed for the study. Data was analyzed using descriptive statistics embedded in SPSSv20. Results confirmed that farmers in the municipality employed several Climate-Smart Agriculture practices which helped in reducing the incidence of poverty and food insecurity