bluuebunny/crossref_metadata_2025 huggingface dataset:
SNORA5A regulates tumor-associated macrophage M1/M2 phenotypes via TRAF3IP3 in breast cancer
Authors: Zhang Yiqi , Zheng Ang , Shi Yue , Lu Heng
Published: November 2022

SnoRNAs have robust potential functions and therapeutic value in breast cancer. Herein, we investigated the role SNORA5A in breast cancer. This study reviewed samples from TCGA. The transcription matrix and clinical information were analyzed using R software and validated in clinical tissue sample. SNORA5A was significantly down-regulated in breast cancer and high expression of SNORA5A correlated with a favorable prognosis. High expression of SNORA5A induced high concentration of tumor-associated macrophages M1 and low concentration of tumor-associated macrophages M2. Moreover, SNORA5A were clustered in terms related to cancer and immune functions. Possible downstream molecules of SNORA5A were identified, among which TRAF3IP3 was positively correlated with M1 and negatively correlated with M2. The function of TRAF3IP3 in tumor inhibition and its relation with macrophages in clinical tissue samples were in accordance with bioinformatics analysis results. Hence, SNORA5A could regulate macrophage phenotypes through TRAF3IP3 and serves as a potential prognostic marker for breast cancer patients.
A Mechanical Analysis of Zhang’s knot, a New Slip Knot with Locking Mechanism
Authors: Han Qing-xin , Ma Jia , Zhang Lei , Tong Yi , Li Yan
Published: November 2022

Background: An effective knot, which is used under the arthroscopy, must possess the optimal balance of knot security and loop security. The aim of this research was to assess the biomechanical performance of the Zhang’s knot, a new slip knot, comparing with Tennessee knot, Roeder knot, and SMC knot.
Methods: The Zhang’s knot and other 3 arthroscopic sliding knots (Tennessee knot, Roeder knot, and SMC knot) were tied with 3 reversing half-hitches on alternating posts (RHAPs) following. A total of 60 specimen of 5 different types of knots were assessed, with the static surgeon’s knot as comparison. The knots were tied around a 30 mm circumference plastic post for a unified 30 mm loop circumference before locking the complex knots by tensioning the wrapping limb of the suture. The loop security (the capacity of knot maintaining a tight suture loop without slippage) was assessed based on the circumference of knots under 5 N preload; the knot security was assessed based on the maximum force to failure at 3 mm of crosshead displacement or suture breakage during single-pull load testing.
Results: Regarding the loop circumferences, under 5 N preload, the Zhang’s knot was not significantly different from Tennessee knot (P = 0.396), but smaller than SMC knot (P = 0.029), Roeder knot (P = 0.007) and surgeon’s knot (P = 0.007). In term of load-to-failure, the Zhang’s knot was not significantly different from Tennessee knot (P = 0.077) and SMC knot (P = 0.903), but stronger than Roeder knot (P = 0.030) and surgeon’s knot (P < 0.001).
Conclusions: The Zhang’s knot is easily reproducible and shows a great balance of loop security and knot security just as Tennessee knot with 3 RHAPs.
Healthy Lifestyle and all-cause and cause-specific dementia in Individuals with or without Type 2 diabetes: the roles of diabetes duration and insulin use
Authors: Zhou Chunmiao , Dong Caiyun , Wang Qi , Fu Chunying , Xie Ziwei , Hao Wenting , Sun Huizi , Zhu Dongshan
Published: November 2022

Background
Diabetes and dementia share common lifestyle risk factors, while few studies have examined the effect of seven healthy lifestyle factors as recommended by the diabetes management guidelines on all-cause and cause-specific dementia in individuals with type 2 diabetes (T2DM). Also, the roles of diabetes duration and insulin therapy in their association remain unclear.
Methods
This study analyzed data of 459 840 participants from the UK Biobank. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CI) for the association of an overall healthy lifestyle score (derived from smoking, social connection, alcohol consumption, physical activity, sedentary, sleep duration and diet) with all-cause and cause-specific dementia of Alzheimer's disease (AD), Vascular dementia (VD) and Non-Alzheimer non-vascular dementia (NAVD), using people without T2DM as the reference group. We also analyzed the role of diabetes duration and insulin use on the association between lifestyle score and dementia.
Results
During a mean follow-up of 12.1 years, 5 268 incident dementia events were recorded. Using diabetes-free participants who had a lifestyle score of 5–7 as reference group, in diabetes-free participants, we observed a clear trend that higher healthy lifestyle score was related to lower risk of all-cause and cause-specific dementia. However, in people with T2DM, we did not observe such a trend with all-cause dementia. People with lifestyle score of 2–3, 4 and 5–7 all had around two-time risk of all-cause dementia (HR: 2.20–2.36), while those with a score of 0–1 had over three-time risk (HR: 3.14, 95% CI 2.34–4.21). After separating the analyses with dementia subtypes, a dose-response trend was only observed with VD (each two-point increase: 0.75, 0.61–0.93), and no significant association with AD (0.95, 0.77–1.16). The reduced risk of all-cause dementia, AD, VD, and NACD with higher lifestyle score was only observed in patients with diabetes duration less than 10 years, or in patients with no insulin use.
Conclusions
In people with T2DM, higher healthy lifestyle score was associated with lower risk of all-cause dementia, while the relationship with cause-specific dementia was inconsistent. A dose-response trend was only observed with VD, not with AD. The beneficial effect of healthy lifestyle was only observed in people with diabetes duration less than 10 years, or in those with no insulin use.
A versatile hybrid image fusion model to fuse multispectral image data
Authors: Ignatious Henry Alexander , El-Sayed Hesham , Khan Manzoor Ahmed , Kulkarni Parag
Published: November 2022

Higher-level autonomous driving necessitates the best possible execution of important moves under all conditions. Most of the accidents in recent years caused by the AVs launched by leading automobile manufacturers are due to inadequate decision-making caused by their poor perceivance of environmental information. In todays, technology-bound scenarios, versatile sensors are used by AVs to collect environmental information. Due to various technical and natural calamities, the environmental information acquired by the sensors may not be complete and clear, due to which the AVs may misinterpret the information in a different context leading to inadequate decision making causing fatal accidents. To overcome this drawback effective preprocessing of raw sensory data is a mandatory task. Pre-processing the sensory data involves two vital tasks namely data cleaning and data fusion. Since the raw sensory data is complex and exhibits multimodal characteristics, more emphasis is given to data preprocessing. Since more innovative models have been proposed for data cleaning, this study focuses on data fusion. In particular, we propose a generic data fusion engine, which classifies different formats of sensory data and fuses them accordingly to improve accuracy. This study proposes a generic framework to fuse the text, image, and audio data. In the first stage of this research, an innovative hybrid model is proposed to fuse multispectral image and video data. Simple and efficient models to extract the salient image features are also proposed. The proposed models are evaluated using various standard metrics with existing popular models. The proposed image fusion model performed better than the other models.
A Study on the Possible Mediating Role of Covid-19 Pandemic in Psychological Distress and Disordered Eating Behaviours Among Young Adults
Authors: Awasthi Snigdha , Ephraim Rufus
Published: November 2022

Background
The COVID-19 pandemic-associated social restrictions brought various challenges among the youth, including mental health issues and disordered eating patterns. It, therefore, becomes imperative for clinicians to know the extent and causative factors of the problem.
Objectives
To explore the prevalence and possible mediation role of the COVID-19 pandemic in causing mental distress and disordered eating behaviors among Indian adults between 18–35 years old.
Methods
This was a month-long, community-based, cross-sectional study conducted via an online questionnaire. The Coronavirus Impact Scale (CIS), Depression, Anxiety, Stress Scale (DASS-21), SCOFF questionnaire for eating disorders, and Three-Factor Eating Questionnaire-Revised 18-item version (TFEQ-18) were used. In addition, the mediation effects of the psychosocial impact of the pandemic, psychological distress, and disordered eating behaviors, were tested using PROCESS v4.0 by Andrew Hayes.
Results
49% of the subjects (n = 101) reported stress and discord in their families due to the pandemic. 10% of the respondents reported features suggestive of moderate depression and anxiety, while almost 10% of the participants suffered from a likely eating disorder, requiring further clinical evaluation. A positive association was observed between psychosocial stress due to COVID-19 and depression (r = 0.366, p < 0.001), anxiety (r = 0.402, p < 0.001) and stress (r = 0.416, p < 0.001). Also, on mediation analysis, the pandemic-induced psychological distress was found to significantly affect disordered eating patterns (b = 0.104, CI = 0.09, 2.17).
Conclusions
The COVID-19 pandemic has caused or aggravated significant psychological distress and, in turn, has indirectly mediated disordered eating patterns among the younger population, who are already at higher risk for developing mental disorders.
Improved Macromodeling Helps Sizing of Multi-stage Op Amps – A Case Study
Authors: Xie Qixu , Shi Guoyong
Published: November 2022

Behavioral modeling of analog integrated cir- cuits has many applications. When used for sizing, ac- curacy of compact models can be used for directly eval- uating part of circuit performance targets, helping to quickly forming initial sizing for further iterations. In this paper we elaborate on modeling improvement of the current buffer (CB) compensation recently received attention in multi-stage operational amplifier (op amp) designs. Limitation in conventional models is pointed out and improvement is proposed. We demonstrate via cases that the improved macromodels can leverage the eﬀiciency of sizing by incorporating the gm/ID method.
Knowledge of Stroke Risk Factors and Warning Signs Among High Risk Individuals in Nnewi North and South Local Government Areas, Anambra State, Nigeria
Authors: Akosile Christopher Olusegun , Okonkwo Uchenna Prosper , Aninyei Desmond , Raji Najim Olayiwola , Abdullahi Auwal , Okoye Emmanuel Chiebuka , Odetunde Morufat Oluyemisi , Akobundu Uzoamaka Nwakego , Okafor Christiana Nkiru
Published: November 2022

Background: Increasing the level of knowledge of stroke risk factors and warning signs among individuals at high risk for stroke may empower them for positive health actions.Aim: This study assessed the knowledge of stroke risk factors and warning signs among individuals at increased risk and the association between these knowledge levels and some of the participants’ demographics.Method:This study was a cross-sectional survey of one hundred and forty-six individuals (mean age= 53.16±17.66 years) at high risk for stroke from some selected communities in Nnewi North and South Local Government Areas, Anambra State. A self-developed questionnaire was used to measure the participants’ knowledge level.Data Analysis:Data obtained were analyzed using descriptive statistics of frequency counts, percentages, mean and standard deviation while inferential statistics of Chi-square and Spearman rank-order correlation were used for testing the hypotheses at 0.05 alpha-level.Result:Participants' were mostly males 98 (65.07%), married, and gainfully employed (67.1%) and had at least a secondary level education (76.7%). About half of the participants had poor knowledge of stroke risk factors (52.05%) and warning signs (49.32%) despite their high literacy level. Being a male participant with a tertiary level of education and working in the public or private sector was associated with a better knowledge level (p≤0.05). No significant association existed between the age and marital status of the individuals. Knowledge of stroke risk factors and warning signs was poor for many in the sampled population particularly those with little or no education and those who are either unemployed or self-employed. Efforts should be made to increase the level of awareness among these groups of high-risk individuals through stroke awareness campaigns, which may empower them for positive health actions toward stroke prevention.
Reflective practice and self-reliance development among nursing students
Authors: ATMANI Zineb EL , BELLFKIH EL MEHDI , MADRANE MOURAD
Published: November 2022

The nursing student walks through a complex study system in a field full of challenges. He is called upon to embark on a three-year training program that should foster a better link between theory and practice and be part of a professionalization approach, thus ensuring the development of his autonomy. In such a context, taking a step back and questioning the practice on the part of each student remains an area rarely explored. Following the implementation of the competency-based approach, the development of reflective practice (RP) in students and the need to stimulate critical thinking skills in them are a priority. From this perspective, this study aims to study the development of RP among 200 students from 21 ISPITS (Higher Institute of Nursing Professions and Health Technologies) from different corners of the Kingdom of Morocco. It is done using a questionnaire, the internal validity of which has been approved, sent through the Google Forms platform. As such, this quantitative study will focus on two aspects on the first is descriptive exploratory to study the level of development of RP in ISPITS. The second aims to study the relationship between RP and the development of autonomy among nursing students and to verify the existence of a possible impact on their academic success. The results show a positive impact on the importance given to RP in ISPITS training. Also, the statistical tests demonstrated a positive impact of the RP on the development of autonomy and on the students' success.
Über den Zusammenhang von sozialer Exklusion und Mobilität. Konzeptionelle Überlegungen zur Einrichtung eines Reallabors in der Region Hannover
Authors: Rozynek Caroline , Schwerdtfeger Stefanie , Lanzendorf Martin
Published: November 2022

Mobilität ist eine wesentliche Voraussetzung für soziale Teilhabe. Jedoch ist Mobilität mit Kosten verbunden, sodass die soziale Teilhabe bei geringen finanziellen Mitteln gefährdet sein kann. Das Projekt Social2Mobility begegnet dieser Problematik, indem es das Ziel verfolgt, die soziale Teilhabe von Menschen, die von finanzieller Armut betroffen oder bedroht sind, durch Stärkung ihrer Mobilität zu steigern. Um dieses Ziel zu erreichen, soll im Rahmen des Projektes in der Region Hannover ein Reallabor eingerichtet werden. Das Arbeitspapier begleitet dessen Konzeption und geht der Frage nach, inwiefern in der Region Hannover ein Reallabor zum Thema mobilitätsbezogene soziale Exklusion eingerichtet werden kann. So werden in diesem Arbeitspapier die konzeptionellen Überlegungen zur räumlichen Verortung, zur Zielgruppenauswahl und zu möglichen Themen für das Reallabor dargestellt. Zudem werden die Spezifizierung auf die Zielgruppen Haushalte mit Kindern und ältere Menschen (ab 60 Jahren) sowie die Auswahl der Kommune Ronnenberg als Verortung für das Reallabor begründet.
Nachhaltige Mobilität in Lincoln
Authors: Klein Marcu , Klinger Thomas , Lanzendorf Martin
Published: November 2022

Die Lincoln-Siedlung, eine ehemalige Housing Area der US-Army im Süden von Darmstadt, wird seit dem amerikanischen Truppenabzug im Jahr 2008 als autoreduziertes Wohnquartier entwickelt. Der Autobesitz der Bewohner*innen wird über eine zentrale Stellplatzvergabe mit einem Stellplatzschlüssel von 0,65 Parkplätzen pro Wohneinheit reglementiert. Gleichzeitig stehen zahlreiche Alternativen, wie eine verbesserte Fuß- und Radverkehrsinfrastruktur, eine eng getaktete ÖPNV-Verbindung in die Innenstadt, mehrere (teils vergünstigte) Carsharing- und Fahrradverleihangebote sowie eine Mobilitätsberatung zur Verfügung. Die vorliegende Studie stützt sich auf eine quantitative Haushaltsbefragung (N = 166), evaluiert die genannten Elemente alternativer Mobilität aus Bewohner*innensicht und untersucht die umzugsbedingten Veränderungen im Mobilitätsverhalten der Bewohner*innen. Diese befürworten die Maßnahmen grundsätzlich, bezweifeln jedoch teilweise deren Wirksamkeit, etwa hinsichtlich der Minderung von Verkehrsaufkommen und Schadstoffbelastung. Im Hinblick auf das Mobilitätsverhalten zeigen die Daten eine signifikante Verringerung von Besitz und Nutzung privater Pkw im Vergleich zum Zeitraum vor dem Umzug in die Lincoln-Siedlung. Die Nutzung von Carsharing-Angeboten sowie Bus und Bahn ist hingegen signifikant angewachsen. Diese Veränderungen sind hinsichtlich der überwiegend kurzen Wohndauer der befragten Personen sowie der andauernden Quartiersentwicklung bemerkenswert. Als künftige Maßnahmen konnten bessere Informationen über das Gesamtkonzept und die einzelnen Mobilitätsangebote sowie die Kommunikation von Visionen der fertiggestellten Siedlung identifiziert werden.
Evaluation des hessischen Landestickets
Authors: Klinner Nora , Kraus Monika
Published: November 2022

Seit dem 1. Januar 2018 erhalten alle aktiven Beamt*innen, Richter*innen, Tarifbeschäftigte und Auszubildende des Landes Hessen eine Freifahrtberechtigung, sodass sie den öffentlichen Personennah- und Regionalverkehr im gesamten Bundesland kostenlos nutzen können. Diese Umstellung stellt den Anlass für die Fallstudie dar, die die Auswirkungen der Einführung eines solchen Tickets am Beispiel der Beschäftigten der Goethe-Universität Frankfurt untersucht. Im Frühjahr 2019 wurde eine quantitative Online-Befragung an der Goethe-Universität durchgeführt (n=1686). Als Grundlage und Vergleichsdatensatz diente eine Studie, die im Jahr 2015 an der Goethe-Universität durchgeführt worden ist. Ziel der Befragung war es, Informationen über die Verkehrsmittelnutzung sowie die Einstellungen zu unterschiedlichen Mobilitätsangeboten zu erhalten. Der Schwerpunkt der Befragung lag dabei auf der Nutzung des hessischen Landestickets, sodass die Forschungsfrage untersucht wurde, welche mobilitätsbezogenen Verhaltensänderungen das hessische Landesticket hervorruft. Im Vergleich der Befragungen unter den Beschäftigten der Goethe-Universität 2015 und 2019 lässt sich in der Studie von 2019, ein Jahr nach der Einführung des hessischen Landestickets, ein signifikanter Anstieg der regelmäßigen Nutzung des öffentlichen Verkehrs erkennen. Im Hinblick auf eine erhoffte Verkehrswende weg von motorisiertem Individualverkehr hin zu ökologisch freundlicherem, öffentlichem Personennahverkehr lassen sich aus diesem Ergebnis politische Implikationen ableiten.
Idiopathic Bone Cavity of Mandibular Symphysis: a Case Report
Authors: Lima Luciano Henrique Ferreira , Di Spagna André Raymundo , Tunel Fernando Matheus Santana , Sverzut Alexander Tadeu
Published: November 2022

Introduction:An idiopathic bone cavity of the jaw is a rare pseudocyst with unclear etiology and is most commonly found in the body of the mandible. This lesion is generally asymptomatic and incidentally discovered on dental radiographs. Objetives:The aim of this study is to report the case of a 15-year-old male with surgical treatment of this lesion involving the mandibular symphysis, but the vitality pulp was positive. Conclusion: Although there is a non-surgical or surgical option for the treatment of this lesion, the latter is most indicated due to the possibility of a definitive diagnosis and improving bone repair.
Substantiation of the efficiency of the method for processing viburnum by the method of osmotic dehydration
Authors: Samilyk Marina , Korniienko Daria , Demidova Evgenia , Tymoshenko Anna , Bolgova Natalia , Yeskova Oksana
Published: November 2022

In the process of any food production, it is important not only to obtain a high quality product, but also to minimize industrial waste, reduce energy costs for the process. Recently, buyers are also paying special attention to the biological value, the popularity of organic and natural products is growing. The search for new types of non-traditional raw materials and the choice of a rational way of processing it is an important task for scientists and manufacturers. The subject of the study was the viburnum fruits (Viburnum opulus). The object is the process of osmotic dehydration. The purpose of the study is to substantiate the effectiveness of the method of processing Viburnum opulus fruits by the method of osmotic dehydration. The process of processing viburnum fruits provides for mandatory pre-freezing, defrosting, osmotic dehydration and drying. A method was developed for waste-free processing of viburnum fruits using the process of osmotic dehydration. Products of viburnum processing (osmotic solution and powders) were studied. Analysis of the mineral composition of powders of their derivatives from the processing of viburnum showed the highest content of potassium (5.74 %). In addition, vitamin C was found in the products of viburnum processing: in powders – 8.28 mg/100 g, in an osmotic solution − 1.12 mg/100 ml. Given that wild berries were used for the study, a study of powders for the presence of microorganisms and heavy metals was carried out. Mesophilic aerobic, facultative anaerobic microorganisms, yeasts and molds were not detected. The content of heavy metals is less than 10 ppm Pb. Thus, viburnum fruits are safe raw materials. When using osmotic dehydration, their biological value and organoleptic properties are preserved.
The spread of Parlatoria cinerea Hadden 1909, and the plants which it parazitises in the south of Albania
Authors: Hasani Lavdi
Published: November 2022

In the following material, the role of one of the parasites of citrus fruits and ornamental plants is treated, that of Parlatoria cinerea Hadden 1909. Among the representatives of the U/Order Coccinea, Order Hemiptera, Class Insecta, P. cinerea Hadd. 1909; is presented as one of the most widespread pests among all representatives of the Parlatoria genus analyzed in our study. To determine this species, it is necessary to familiarize ourselves with many of its determining characteristics. It should be emphasized that, in this material, the distribution of this species in the entire territory kept under control is also dealt with. This group of parasites precisely in the Region of South-Western Albania has studied.

The paper, in addition to the spread of the species in question, also identifies the entire variety of vegetation that it frequents, the plant organs where the insect prefers to parasitize, and also the frequency of plant liking by it.

In this paper, in addition to the species P.cinerea Hadden 1909, data on other representatives of the genus ParlatoriaTargini - Tozzetti, 1868 are also treated, such as: P. eleae Colv., P. thea Ckll. and P. pergandii Comst. By presenting in a comparative manner the data collected for all these species found in the region in question, the role and importance of the study of this species is highlighted. The material also deals with data on the damage caused by it and the negative impacts on the contaminated vegetation. Thus, on the basis of a chronological work in the field of over 5 years, we have also reached a number of valuable conclusions for citrus growers and equally for park specialists who cultivate and breed ornamental plants in parks of relaxation and in the courtyards of our homes.
Research on accuracy of electrical energy measurement in microgrid for mine dewatering
Authors: Vasylets Kateryna , Vasylets Sviatoslav , Kylymchuk Anton
Published: November 2022

The object of the study is the current transformers of the electricity metering unit as part of the microgrid for mine dewatering, which includes a photovoltaic station. The need to pump mine waters is caused by the danger of flooding large areas. The introduction of a photovoltaic station to power underground pumps reduces electricity consumption from the central power grid. At the same time, it changes the operating conditions of the metering unit. There is a need to measure both the currents of the pumps in the absence of solar generation, as well as relatively small current flows in the case of commensurate capacities generated and consumed within the microgrid. A feature of electromagnetic current transformers is a decrease in the accuracy of operation if the primary current is several percent of the rated value. Based on the analysis of variance of the experimental data, it was established that there is a statistically significant connection between the secondary and primary currents of the measuring transformer at insignificant values of the primary current. Estimates of the values of the linear regression parameters that link the secondary and primary currents were determined. It was established that in the range of the transformer primary current from 0.22 % to 1.4 %, the current error reaches a value of 6.7 %. Taking into account the resulting dependence in the software of the electricity metering unit will make it possible to increase the accuracy of energy metering. Accordingly, the accuracy of financial calculations will be increased
The comparison of the dimensionality results provided by the automated item selection procedure and DETECT analysis
Authors: MOR DİRLİK Ezgi , KARTAL Seval
Published: November 2022

The dimensionality is one of the most investigated concepts in the psychological assessment, and there are many ways to determine the dimensionality of a measured construct. The Automated Item Selection Procedure (AISP) and the DETECT are non-parametric methods aiming to determine the factorial structure of a data set. In the current study, dimensionality results provided by the two methods were compared based on the original factorial structure defined by the scale developers. For the comparison of the two methods, the data was obtained by implementing a scale measuring academic dishonesty levels of bachelor students. The scale was conducted on junior students studying at a public and a private university. The dataset was analyzed by using the AISP and DETECT analyses. The “mokken” and “sirt” packages on the R program were utilized for the AISP and DETECT analyses, respectively. The similarities and differences between the findings provided by the methods were analyzed depending on the original factor structure of the scale verified by the scale developers.
Views of academician examiners on the testing accommodations of the measurement, selection and placement center for disabled test takers
Authors: İLHAN Mustafa , ŞAHİN Melek Gülşah , ÇETİN Bayram
Published: November 2022

The Measurement, Selection and Placement Center–MSPC (original acronym: Ölçme, Seçme ve Yerleştirme Merkezi–ÖSYM) administers many of the high-stake examinations applied in Türkiye. In order to support equality of opportunity in education and create a fair evaluation system, MSPC actualizes various testing accommodations by adjusting the standardization protocol for disabled test takers. In this research, we examined the views of academicians who served in the halls where disabled candidates take the test in the examinations held by MSPC about the testing accommodations for the disabled. The study design was in the basic qualitative research model. The participants consisted of 12 academicians working at a state university in Türkiye, who had served at least three times in the examination halls reserved for disabled test takers by MSPC. We collected the data via an interview form which included four items and administered it to the participants according to the drop-off and pick-up later method. The research results revealed that academician examiners have various positive opinions about MSPC’s testing accommodations for disabled test takers. However, the participants also expressed that current accommodations have certain limitations that should be revised.
An observational look at classroom practices in the Turkish language teaching process
Authors: KÖROĞLU Mustafa , BALCI Ahmet
Published: November 2022

The aim of this study is to determine the practices of middle school 8th grade Turkish teachers towards comprehension (reading) teaching in the process of learning-teaching Turkish lessons and how long they allocate for these practices. The model of the research is the case study model, which is one of the qualitative research methods. The participants of the study consist of five Turkish teachers who gave eighth grade Turkish lessons in the 2019-2020 academic year and participated in the study voluntarily. In the study, an "Observation Form" developed by the researcher was used as the data collection tools. Literature review was used in the development of measurement tools, expert opinion was obtained, and the level of harmony between coders was examined. Descriptive statistical techniques (frequency, percentage, average, etc.) were used to analyze the data. In the study, each of the teachers wrote five to the poem text "Kaldırımlar" (Sidewalks) in the theme "Individual and Society", the informative text "Gündelik Hayatımızda E-Hastalıklar" (E-Diseases in Our Daily Life) in the "Science and Technology" theme and the narrative text "Göç Destanı" (Epic of Migration) under the theme "Our National Culture" lesson time (600 minutes) had been allocated. Accordingly, 75 lesson hours (3000 minutes) of five Turkish teachers were observed in total. As a result, it was seen that 8th grade Turkish lesson teachers, whose teaching process was observed in our study, used only the texts and activities related to the texts while applying comprehension (reading) strategies in the Turkish lesson learning-teaching process.
Efficient and scalable path integral Monte Carlo simulations with worm-type updates for Bose-Hubbard and XXZ models
Authors: Sadoune Nicolas , Pollet Lode
Published: November 2022

We present a novel and open-source implementation of the worm
algorithm, which is an algorithm to simulate Bose-Hubbard and
sign-positive spin models using a path-integral representation of the
partition function. The code can deal with arbitrary lattice structures
and assumes spin-exchange terms, or bosonic hopping amplitudes, between
nearest-neighbor sites, and local or nearest-neighbor interactions of
the density-density type. We explicitly demonstrate the near-linear
scaling of the algorithm with respect to the system volume and the
inverse temperature and analyze the autocorrelation times in the
vicinity of a U(1)U(1)
second order phase transition. The code is written in such a way that
extensions to other lattice models as well as closely-related
sign-positive models can be done straightforwardly on top of the
provided framework.
RNAI TECHNOLOGY AND ITS APPLICATION-REVIEW
Authors:   SardarBhagwan Singh Post Graduate Institute Of Biomedical Sciences And Research HNB Garhwal University, Uttarakhand Dehradun, Balawala., Kaul Rashmi , Nautiyal Anjali ,   GB Panthnagar University, Uttrakhand.
Published: November 2022

RNA interference (RNAi), an evolutionarily conserved mechanism triggered by double-stranded RNA (dsRNA), causes gene silencing and inhibit translation in a sequence-specific manner. This technique was first time discovered in Nematode Caenorhabditiselegans.The specificity and robustness of RNAi have triggered an immense interest in using RNAi as a tool in various settings which results intovarious significantachievements in the area of therapeutics, crop protection, crop production, weed management etc. Furthermore, it has found to have immense potential in controlling agricultural and non agricultural pest such as pathogen i.ebacteria, fungi & virus, insect pest and nematodes. Moreover, RNAi leads to theenhancement of micronutrient or macronutrient bioavailability, improved salinity and droughttolerance as well as enhanced resistance toextreme hot and cold temperature tolerance.In this paper, we first reviewed the RNAi technology and its mechanism and then focused on of its applications in agriculture and biomedical research such as treatment for HIV, viral hepatitis and several other diseases.
A STUDY TO EVALUATE THE HEARING EFFICACY OF BONE CEMENT OSSICULOPLASTY FOR INCUDOSTAPEDIAL REBRIDGING
Authors: Natarajan Dhinakaran , Rajangam Vinodh , Raju Malaichamy Monisha
Published: November 2022

Background:The goal of surgery in cases with chronic otitis media both safe and unsafe types is to achieve a maximal disease clearance and restore the near normal hearing. Various techniques of ossiculoplasty have been used to reconstruct the eroded ossicular chain. The ideal material to be employed in ossiculoplasty techniques should be bio active, bio compatible, safe, stable and with easier to apply. Hydroxyapatite, which is a calcium phosphate compound bone cement is similar in composition to living human bone and satisfies all the all above characteristics of an ideal ossiculoplasty material. Objectives:The purpose of this study is to evaluate the hearing outcomes of hydroxyapatite bone cement ossiculoplasty done in patients with incudostapedial erosion in both safe and unsafe types of chronic otitis media. The study is also aimed to determine the ideal candidates for bone cement ossiculoplasty. Methodology:A total of thirty patients of chronic otitis media with incudostapedial erosion were included in the study. Patients underwent ossicular reconstruction with hydroxyapatite bone cement. Preoperative and post operative hearing results with pure tone audiogram and impedance audiometry were recorded. One year period of follow up was done and reduction in air bone gap was analyzed. Results:The post operative air bone gap was found to be significantly reduced after a period of follow up of one year. The mean preoperative and postoperative pure tone averages was found to be 47.46 and 36.86 respectively. The mean preoperative and post operative air bone gaps were 37.89 and 27.28 respectively with p<0.001. No complications were recorded during the study in relation to the bone cement. Conclusions:Incudostapedialrebridgingossiculoplasty with hydroxyapatite bone cement is a safe and reliable method that is cost effective and provides significant hearing outcomes in selected patients with no complications recorded.
MECKEL GRUBER SYNDROME- A RARE CASE REPORT
Authors:   Department of Obstetrics and Gynaecology., Shireesha Chinthala , Manasa A. ,   Kurnool Medical College, Kurnool.
Published: November 2022

Meckel Gruber Syndrome is a rare and lethal autosomal recessive congenital anomaly syndrome, characterized by a triad of : occipital encephalocele Postaxial polydactyly, bilateral dysplastic cystic kidneys and other occasional features. Diagnosis can be made on ultrasonography with atleast two of the major features. Here we present a pregnant women complicated with meckel gruber syndrome. We relayed on ultrasonography findings and MRI ,preganancy was terminated at 22weeks of gestational age. Ultrasonography, MRI and clinical examination of bady after termination suggestive of Meckel Gruber Syndrome.
CHANGE IN LEARNING PERCEPTION DURING PANDEMIC AND BEYOND
Authors:   Department of Geography Naba Barrackpur Prafulla Chandra Mahavidyalaya, West Bengal State University, Kolkata- 700131., Banerjee Mallicka
Published: November 2022

Since 2020, entire world adopted effective measures to counter the spread of deadly pandemic, caused by the virus SARS-CoV-2 (COVID-19). Restrictions, in terms of movement of people and goods, which was imposed by the governments, compelled various institutions to search for alternative approaches to maintain their stipulated work flow. Online platforms appeared to be best suited approach to cope-up with the altered and challenging environment. Education system was under the purview of these restrictive measures as well. As all the educational institutions were closed for a longer period of time, authorities tried online platforms, as a new avenue to provide education to the students. To provide effective and productive education, both the interactive (bidirectional) and non-interactive (unidirectional) communication strategies were adopted. In this longitudinal study, perception of three groups, i.e. Higher Secondary, Under Graduate and Post Graduate students were evaluated. Perception regarding online mode of education and gradual transition thereafter toward regular mode of education were taken into account while this study was conducted. To carry out this evaluation, two tier structured questionnaire survey was conducted amongst 320 students through the stratified random sampling. In the first tier, survey conducted through online mode, whereas, second tier of survey was carried out through off line/regular mode, that is after reopening of institutions from January,2022. This study suggested that, as far as access to the online mode of education is concerned, 87.50% students marked it to be the most positive factor whereas, 92% students considered network to be the major barrier. Study also revealed that there are perception wise differences amongst Higher Secondary and Under Graduate students. However, it could be opined from this study that after re-entering into offline mode, most of the students faced learning deterioration.
Finding God’s Way: Spiritual Well-Being on the People Who Do Tirakat Mlaku
Authors: Himawanti Izza , Hamzah Imam Faisal , Faiq Muhammad
Published: November 2022

One of the ways to get closer to God is to escape from the world's temptations by going on a journey (safar, mlaku). This study aims to uncover the meaning of spiritual well-being in individuals who perform tirakat mlaku. This article is qualitative research with a phenomenological approach. The subject of this study is the congregation (jemaat) of Sheikh Abdullah Ibn Mas'ud Sukabumi, who perform tirakat mlaku. Data were collected through semi-structured interviews and using interpretive phenomenological analysis. This study found that there are three meanings for those who undergo tirakat mlaku: (1) quality of life, (2) social well-being, and (3) environment well-being. This study also reveals that spiritual well-being is an interrelationship between one's relationship with God, subjective well-being, and socio-environment well-being. This article provides a new perspective on the concept of tirakat as a path to closeness to God, directly affecting the quality of life, social life, and environmental protection.Contribution: The results of this study can be used as a guide in constructing the dimension of spiritual well-being in the context of Islamic psychological theory. While practically, it provides an outlook of the meanings of divinity that are implemented in social activities.
A Small Beautiful Example of Sustainability in the Heart of Zimbabwe
Authors: Venkatesh G
Published: November 2022

Zimbabwe has diligently started pursuing the Sustainable Development Goals (SDGs) defined by the United Nations in 2015. While making progress and being aware of it, will be a shot in the arm, with success breeding more success, the journey may seem daunting at times. However, the journey – sustainable development towards the targets set - is what matters more than the final destination, as philosophers and savants often remind us. This article, while dwelling on sustainable development in this southern-African landlocked country in general, presents a beautiful example of a collaborative venture, undertaken by dedicated and determined international partners, and predicated on SDG#4 (Quality Education) and SDG#5 (Gender Equality), and harnessing the complementarities and synergies with the other SDGs, which set root during the COVID-pandemic, in Mwenezi in southern Zimbabwe. The pandemic while being a scourge, tended to have some silver linings to it, as it gave birth to many collaborations and made human beings realise that one’s own happiness is dependent to a very great extent on that of others. This venture emphasizes girls’ education and skills-development, which open the doors, synergistically, to sustained growth, development and progress. Education, indisputably, is a key component of the freedom necessary to live a life of value. To quote Nelson Mandela, ‘It is the most powerful weapon which you can use to change the world.”
Statistical Inferences of HIVRNA and Fracture Based on the PAK1
Expression via Neural Network Model
Authors: Yuan Zheng , Ma Rui , Zhang Qiang , Zhao Chang-song
Published: November 2022

Background:

Acquired immune deficiency syndrome and fracture are all serious hazards
to human health that create a widespread alarm. Biomarkers that are closely linked to HIVRNA and
fracture are unknown.

Methods:

48 cases with HIV and fracture and 112 normal cases were recruited. Blood neutrophil
count (NEU), white blood cell count (WBC), PAK1 and HIVRNA were measured. Pearson's chisquared
test was used to evaluate the association between HIVRNA with fracture and NEU, WBC,
PAK1. BP neural network model was constructed to analyze the predictive power of the combined
effects of NEU, WBC, PAK1 for HIV RNA with fracture.

Results:

There exist strong correlations between PAK1, NEU, WBC and HIVRNA with fracture.
The neural network model was successfully constructed. The overall determination coefficients of
the training sample, validation sample, and test sample were 0.7235, 0.4795, 0.6188, 0.6792, respectively,
indicating that the fitting effect between training sample and overall was good. Statistical
determination coefficient of the goodness of fit R2 ≈ 0.82, it can be considered that degree of fit
between the estimate and corresponding actual data is good.

Conclusion:

HIVRNA with fracture could be predicted using a neural network model based on
NEU, WBC, PAK1. The neural network model is an innovative algorithm for forecasting HIVRNA
levels with fracture.
Chemical Kindling as an Experimental Model to Assess the Conventional
Drugs in the Treatment of Post-traumatic Epilepsy
Authors: Aghdash Simin Namvar , Foroughi Golsa
Published: November 2022

Background:

Traumatic brain injury (TBI) is one of the leading causes of morbidity and
mortality today, which will surpass many infectious diseases in the coming years/decades. Posttraumatic
epilepsy (PTE) is one of the most common debilitating consequences of TBI. PTE is a secondary,
acquired epilepsy that causes recurrent, spontaneous seizures more than a week after TBI. The
extent of head injury in individuals who develop PTE is unknown; however, trauma is thought to account
for 20% of symptomatic epilepsy worldwide. Understanding the mechanisms of epilepsy following
TBI is crucial for the discovery of new anticonvulsant drugs for the treatment of PTE, as well
as for improving the quality of life of patients with PTE.

Objective:

This review article explains the rationale for the usage of a chemical model to access new
treatments for post-traumatic epilepsy.

Results:

There are multiple methods to control and manage PTE. The essential and available remedy
for the management of epilepsy is the use of antiepileptic drugs. Antiepileptic drugs (AEDs) decrease
the frequency of seizures without affecting the disease's causality. Antiepileptic drugs are administrated
for the prevention and treatment of PTE; however, 30% of epilepsy patients are drug-resistant, and
AED side effects are significant in PTE patients. There are different types of animal models, such as
the liquid percussion model, intracortical ferric chloride injection, and cortical subincision model, to
study PTE and neurophysiological mechanisms underlying the development of epilepsy after head injury.
However, these animal models do not easily mimic the pathological events occurring in epilepsy.
Therefore, animal models of PTE are an inappropriate tool for screening new and putatively effective
AEDs. Chemical kindling is the most common animal model used to study epilepsy. There is a strong
similarity between the kindling model and different types of human epilepsy.

Conclusion:

Today, researchers use experimental animal models to evaluate new anticonvulsant drugs.
The chemical kindling models, such as pentylenetetrazol, bicuculline, and picrotoxin-induced seizures,
are important experimental models to analyze the impact of putative antiepileptic drugs.
Effectiveness of an Educational Intervention on Clinical Competency among Mental Health Nurses Working at a Government Mental Health Hospital: A Quasi-experimental Study
Authors: Alzahrani Manal S.J. , Sharif Loujain S.
Published: November 2022

Background:

Mental health nurses play an important role in caring for patients with mental illnesses. In order to provide comprehensive mental health nursing care, it is important to establish periodic educational interventions about mental health and psychiatric nursing in any mental health institution. The presence of frequent educational programs can lead to improvements in mental health nurses' clinical competency.

Aim:

To evaluate the effectiveness of an educational intervention on the clinical competency of mental health nurses.

Methods:

A quasi-experiment study pretest and posttest with one group study design were conducted among 80 nurses in a large mental health hospital in Tabuk city, Saudi Arabia. Data were collected by using the clinical competence evaluation in mental health nurses scale to evaluate the effectiveness of an educational intervention on the clinical competency of mental health nurses by comparing the result of the pretest and posttest scores.

Result & Discussion:

The total score for the pre-test was (74.83±14.25/Average), and then the score increased dramatically for the post-test (96.18±26.53/Good) also, the Wilcoxon signed-rank test indicated that Post-test (Mean rank=102) significantly higher than pre-test (Mean rank=59) (U=1480, p<0.001). As a result of the current study, the program showed great effectiveness (p<0.001) with an advantage for post-test.

Conclusion:

The collected data analysis revealed a statistically significant positive effect of educational programs on improving mental health clinical competency, hence, Healthcare organizations and senior decision-makers should develop well designed periodic mental health programs that involve nurses who have a master's and doctorate degrees in mental health nursing to enhance mental health clinical competency.