bluuebunny/crossref_metadata_2025 huggingface dataset:
A Contratação De Serviços Advocatícios E A Lei De Licitações E Contratos
Authors: Ribeiro Rosália Tavares Braga Telles , Melo Lisâneo Macedo Moreira
Published: May 2021

A Administração Pública é regida por princípios que visam garantir o respeito à cidadania e os direitos dos administrados, assegurando a regularidade e a licitude de todos os atos administrativos. Um desses princípios é o da obrigatoriedade de licitar, previsto nas normas constitucionais e infraconstitucionais, e segundo o qual o Poder Público está obrigado a instaurar procedimento administrativo específico para selecionar o candidato mais adequado ao interesse público, sempre que realizar compras e alienações, contratar obras e serviços. Nenhum princípio, todavia, é absoluto. Assim, a própria legislação brasileira prevê exceções à obrigatoriedade de licitar. O objetivo deste trabalho é analisar o alcance de inexigibilidade de licitação para a hipótese da contratação de serviços advocatícios. Para tanto, realizou-se pesquisa bibliográfica em conjunto com o exame da legislação vigente e a análise dos debates sobre a questão pelo Poder Judiciário. A investigação permitiu concluir que os serviços advocatícios, por sua natureza singular, impossibilitam a competição e, consequentemente, enquadram-se na hipótese de inexigibilidade de licitação.
MÁS ALLÁ DEL CAMBIO CLIMÁTICO: IMPLICACIONES DE LA CONTAMINACIÓN MARINA POR AGROQUÍMICOS SOBRE LAS INTERACCIONES SIMBIÓTICAS Y EL ÉXITO ECOLÓGICO DE LOS CORALES
Authors: OCAMPO-ALVAREZ HECTOR , RODRÍGUEZ-ZARAGOZA FABIAN ALEJANDRO
Published: May 2021

Coral reefs are highly productive marine ecosystems that harborahigh biodiversity. The forming organisms of these reefs are the scleractinian corals, which form symbiotic interactions with multiple microorganisms. One of the best known symbiotic interactions in these systems is the one established with the microalgae Symbiodinium. The microalgae produce through photosynthesis up to 90% of the energy required by the coral. On the other hand, Symbiodiniumreceives from the coral an appropriate niche, that protects Symbiodiniumfrom the external environment, from the competition with other organisms and predation; it also provides abundant nutrients produced by other coral symbiontshighlighting the bacteria. As well as this, multiple symbiotic interactions confer metabolic capabilities to corals, which have enabled their capacity to adapt to climate changes for millions of years. However, in recent decades coral reef ecosystems are being extensively decimated. Given the new characteristics of an environment with significant changes sometimes somewhat erratic, probably the interactions that initially provided ecological advantages to corals are no longer sufficient to overcome environmental adversities or that as a result of the changes generated in the environment. The diversity of microorganisms capable of interactions that can be formed with the few remaining microorganisms do not confer to the coral, sufficient adaptative advantages to face the challenge of climate change. In this essay, we argue about the possibility that a decrease in the stock of microorganisms capable of interacting with corals, as a result of marine pollution, is a cause of the loss of biological aptitude of corals to survive in the current global climate change.
Sobre la estética analógica de Mauricio Beuchot
Authors: Granados Valdéz Juan
Published: May 2021

La estética ha resucitado. Después de declararla muerta, o porque se la asociaba con una disciplina impositiva y prescriptiva del arte, o porque no rebasaba las discusiones conceptuales, la estética renace. La estética es el saber de la propia sensibilidad, la teoría de la belleza y la filosofía del arte. No prescribe ni describe, sino que se apropia comprendiendo desde el contexto sus objetos materiales. Igualmente se involucra, incluso se funda, en la epistemología y la ontología, así como se relaciona, porque las implica, con la ética y la política. Para este ensayo se tiene como propósito comentar la estética analógica de Mauricio Beuchot. Se entiende que comentar es mantenerse en (cum) la mente del autor (mentis), esto es, exponer el contenido de un texto para facilitar su comprensión. Con esto se acepta que una estética analógica es una que, fundada y fundamentada en la hermenéutica analógica, evita los extremos univocista y equivocista, y recupera los criterios para las artes, pero aprendiendo las lecciones de la Modernidad y la Posmodernidad y así volver a posicionarse como un quehacer filosófico pertinente.
Adherence Level Of Medical Personnel In Implementing 2019 Postoperative Pain Management Guidelines
Authors: Nasrulloh Nasrulloh , Hamzah Hamzah , Utariani Arie , Susila Dedi
Published: May 2021

Introduction: Inadequate pain management may increase the risk of complications and postoperative chronic pain. Postoperative Pain Management Guidelines of The Anesthesiology and Reanimation Department, Faculty of Medicine Universitas Airlangga/ Dr. Soetomo Hospital Surabaya were arranged in 2019. Purposes: This study aim is to analyze the medical personnel’s adherence in implementing postoperative pain management guidelines. Methods: This is descriptive observational study with retrospective design. Total sampling was carried out on the medical records of patients who underwent elective surgery and received postoperative acute pain management during March-May 2020. Results: A total of 349 patients, most of the pain intensity was moderate (62.8%). The medical personnel adherence with postoperative pain management guidelines was 88.0%. The overall use of multimodal analgesia was 61.0%. Adherence to guidelines on pain category was mostly good adherence: 99.1% in mild pain, 82.6% in moderate pain, and 81.2% in severe pain. The use of multimodal analgesia was found in 12.3% mild pain; 83.6% moderate pain, and 100% severe pain patients. Conclusion: Most of the medical personnel have adhered to the postoperative pain management guideline, and widely-used multimodal analgesia. Systematic evaluation of guidelines implementation, patient satisfaction, and outcomes are needed.
The Correlation Between Nutritional Status And Urine Glucose With Estimated Fetal Weight In Trimester III Pregnant Women At Prima Husada Hospital
Authors: Masruroh Nur , Putro Ragil Santoso Andreas
Published: May 2021

The nutritional status of a pregnant woman can be seen from several things, including the Body Mass Index and the diameter of the upper arm circumference. Urine glucose describes the state of glucose in urine. The well-being of a baby in the womb can be measured through the estimated fetal weight according to the gestational age. This study aims to determine the relationship between nutritional status and urine glucose on the estimated fetal weight. Using a cross sectional research method with a sample of 30 respondents taken at the Prima Husada Hospital Sidoarjo during May-July 2020. The results of the analysis of body mass index and estimated fetal weight obtained p value = 0.337 (> 0.05), on the upper arm circumference and estimates fetal weight obtained p value = 0.03 (<0.05) and in urine glucose and fetal weight estimates obtained p value = 0.19 (> 0.05). In conclusion, there is no relationship between body mass index and estimated fetal weight. There is a relationship between the circumference of the upper arm and the estimated fetal weight. And there is no relationship between urine glucose and estimated fetal weight. Women must prepare physically from before pregnancy to optimize future baby growth. Midwives must also regularly provide health education to improve women's health status
The Effects Analysis of Transformational Leadership, Work Motivation and Compensation on Employee Performance in PT. Sago Nauli
Authors: Purba Kuras , Sudibjo Kusman
Published: May 2021

This study aims to describe the effect of transformational leadership, work motivation and compensation on the performance of employees of PT. Sago Nauli. This research was conducted at PT. Sago Nauli which lasts for 5 (five) months, starting from October 2019 to February 2020. This research uses proportional random sampling method. The population in this study were all employees of PT. Sago Nauli palm oil mill totaling 180 people. The respondents of this study were determined using the slovin formula which numbered 124 (one hundred twenty four) people. The instrument used was a questionnaire to collect data from transformational leadership variables, work motivation, compensation and employee performance variables. Data analysis techniques used are validity test, reliability test, descriptive analysis, multicollinearity test, normality test, heterokedasticity test, multiple linear regression analysis, partial hypothesis test or t test, simultaneous hypothesis test or F test, and calculation of the coefficient of determination. Descriptive analysis results for transformational leadership variables, work motivation, compensation variables and employee performance are in the good category at PT. Sago Nauli. Based on partial analysis, transformational leadership, work motivation, compensation has a positive and significant effect on employee performance at PT Sago Nauli. Simultaneously, transformational leadership, work motivation and compensation have a positive and significant influence on employee performance at PT. Sago Nauli. The contribution of transformational leadership variables, work motivation, and compensation explained the employee performance variable of 0.760 or 76%. The remaining 0.240 or 24% is influenced by other independent variables not examined in this study.
An Exploratory Discussion of a British Apparel Brand in Relation to New Markets: Developing Actionable Recommendations Based on Network, Relationship, and Collaboration Perspectives
Authors: Linh Le Thuy , Oe Hiroko
Published: May 2021

Marks and Spencer (M&S) is a leading UK fashion retailer. However, the organisation is struggling to improve its domestic operation and to achieve its international objectives, most notably manifest through its withdrawal from China. Through conducting a critical analysis and an evaluation of the supply networks of M&S, the global apparel industry and the Chinese market, this discussion paper aims to propose a new set of strategies for M&S’s re-entry.  Based on an analytical discussion, the following actionable recommendations are proposed for the company: (1) to seek suitable network partners in China, (2) to build sustainable relationships with relevant partners to build business strategies based on Chinese consumers’ perspectives and behaviour, and (3) to focus on a new value chain to enhance profitability and sustainability in the new market.
The Effect of the Comprehensive Midwifery Care Model with the One Student One Client (OSOC) Approach to Birth Outcomes in North Aceh Regency
Authors: Rildayani Rildayani , Nurjannah Nurjannah , Saputra Irwan , Yeni Cut Meurah , Usman Said
Published: May 2021

Maternal and Newborn Health is a priority as the main indicator in health. During the pregnancy period until the puerperium it is estimated that as many as 15% can experience life-threatening complications of the mother and baby. However, this death is considered to be prevented through the provision of comprehensive care that can be done with the One Student One Client (OSOC) approach, which is an activity that exists between low-risk pregnant women and midwife students during pregnancy up to 6 weeks post delivery. Objective: This study aims to assess the relationship of comprehensive midwifery care with the One Student One Client (OSOC) approach to birth outcomes (gestational age at delivery, prolonged labor and asphyxia) Method: This study is a retrospective cohort study, using secondary data from medical record documentation Results: Comprehensive midwifery care with the OSOC approach was associated with the occurrence of prolonged labor p value 0.046 (RR 95% CI; 3.2 (1.08-9.74), asphyxia with p value 0.037 (RR 95% CI; 2.57 1.12-6.50) Conclusion: The OSOC method can be used in comprehensive midwifery care for all mothers and babies from pregnancy up to 6 weeks post delivery in an effort to improve birth outcomes.
Analysis of Marketing Strategy of Muslim Street Vendors at Day Night in Efforts to Improve Community Economy in Binjai City
Authors: Dalimunthe Zunaida Riska
Published: May 2021

The obstacles faced by Muslim street vendors at night in an effort to improve the economy of the people in Binjai City, among others evictions occur, considering that evicted street vendors are usually without compensation because they are considered illegal. Some of the obstacles faced by street vendors in Binjai City include the weather that is easy to change like rain, the need to find a bright location, at least have personal lights, and often thuggery comes at night. As well as people who think that the existence of street vendors in urban areas can be said to be irregular, in general they are not orderly and dirty because they sell on sidewalks, in city parks, even on roads, so that they become or cause traffic jams or damage the beauty of the city. The solution made by Muslim street vendors at night in an effort to improve the community's economy in Binjai City Street vendors in Binjai City from the results of the SWOT analysis found that street vendors are in the growth quadrant with a total score of internal business strength having a number of 3.39 and a total power score the industrial attractiveness is 3.34 where the quadrant shows a very favorable situation. Traders have opportunities and strengths so they can take advantage of the opportunities that exist.
Duethe Heir’s Oral Will of the Heirth before the Tradition of Batak Toba Instruction Happened on the Instructed Land
Authors: Sitinjak Imman Yusuf , Sitinjak Humala , Gultom Sariaman
Published: May 2021

This research aims to identify and discuss the problems and symptoms that occur when death and open inheritance occurs, while the will of the heir has been said verbally to the heirs in the traditional inheritance of Batak Toba. This research discusses the problems that arise when the traditional inheritance of Batak Toba is carried out and there is a verbal will by the heir, especially in the heir's land ownership. The problem that arises when open inheritance is carried out in customary inheritance is a dispute from the heirs who are dissatisfied with the unequal distribution to the heirs, while the heirs who get a portie in inheritance are boys, while for women it is a form of gift given male heirs to girls. In the event of a dispute over inherited land, when the name of the land is transferred to the BPN office, there will be obstacles.
Evaluation of the Mineral Fertilizer Lateral Distribution Performed by Centrifugal Spreaders
Authors:   Rosinformagrotekh, Skorlyakov V.I. , Negreba O.N. ,   Rosinformagrotekh, Nazarov A.N. ,   Rosinformagrotekh, Popelova I.G. ,   Rosinformagrotekh
Published: May 2021

An analysis of the shortcomings of the methodology for assessing the mineral fertilizer distribution performed by centrifugal spreaders is provided. A method is proposed for assessing the spreader fertilizer distribution over the working width using a minimum number of samplers.
Development and Research of a Dehumidifier and an Air Heater Based on Peltier elements
Authors:   VIM, Tikhomirov D.A. , Trunov S.S. ,   VIM, Kuzmichev A.V. ,   VIM
Published: May 2021

A functional flow diagram of an energy-saving dehumidifier and an air heater based on Peltier elements has been developed. A method for calculating the heat-power and design parameters of a thermoelectric assembly is presented. Physical modeling of the process of dehumidification and heating of air in a thermoelectric installation has been carried out. The results of tests of a working model of the thermoelectric dehumidifier and air heater are presented. Rational operating modes of the installation have been substantiated, and its energy efficiency in the heat pump mode has been shown.
Correlation Between Follicle Stimulating Hormone, Anti-Müllerian Hormone and Antral Follicle Count with Different Age Groups in Infertile Women
Authors: Bhowmik Juthi , Fatima Parveen , Banu Jesmine , Deeba Farzana , Chowdhury Sheuli , Isharat Shakeela
Published: May 2021

Background: Reduced ovarian reserve predicts poor ovarian response and poor suc-- cess rates in infertile women who undergo Assisted Reproductive Technology (ART). Ovarian reserve decreases with age but the rate of decline varies from one woman to another. Follicle Stimulating Hormone (FSH) Anti-Müllerian Hormone (AMH) and antral follicle count (AFC) represent the three most frequently utilized laboratory tests in determining Ovarian Reserve (OR). To determine correlation between FSH, AMH and AFC in infertile female.

Materials and methods: It was an observational (Cross sectional) study. This study was done in the Department of Reproductive Endocrinology and Infertility, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, between July 2018 to June 2019. The study population consisted of all the diagnosed female infertility patients of reproductive age. The women attending the study center during study period having primary or secondary infertility was considered as study population. They were divided in 4 age groups 21-25, 26-30, 31-35 yrs and 36-40 yrs years. Data was collected using a structured questionnaire following physical & lab examination. For D2 FSH level fasting blood was collected on D2/3 of menstrual cycle, serum FSH level was measured by ADVIA Centraur(R) XP immunoassay system. For S. AMH level blood sample was collected on 2nd day of cycle and measured by BECKMAN COULTER machine using Chemiluminescent Immunoassay method. For AFC count TVS was done on D2-5 of cycle using KONTRON medical USG machine. Collected data were classified, edited, coded and entered into the computer for statistical analysis by using SPSS version 23.

Results: Out of 74 patients the mean age was found 32.6±5.5 years. Serum FSH, AMH and AFC were significantly associated with different age group. A negative correlation was found between serum FSH and serum AMH in all age group. But strong correlation found in age group 31-35 yrs and in 36-40 years age group. A negative correlation was found between serum FSH and total AFC in age group 26- 30 years, 31-35 years and 36-40 years respectively. A positive correlation was found between serum AMH and total AFC in all age group but most strong in age group 31-35 years. In multivariate logistic regression analysis serum AMH (<1.0 ng/ml) and total AFC (<5 number) were found to be significantly associated with age group >35 years patients.

Conclusion: In all age grqoup, FSH, AMH and AFC correlates but it is more pronounced in advanced age that means >35 years age group.

Chatt Maa Shi Hosp Med Coll J; Vol.20 (1); January 2021; Page 22-27
Pattern of UTI in Chronic Kidney Disease: Experience from A Tertiary Care Hospital, Bangladesh
Authors: Arjumand Marina , Ali Golam Mohammad Tayeb , Dutta Pradip Kumar , Hassan Md Habib , Hasan Kazi Md Abrar , Barua Biplob Kumar
Published: May 2021

Background: Urinary Tract Infection (UTI) is common and higher in prevalence in patients with Chronic Kidney Disease (CKD). To find out the frequency and clinicobacteriological pattern of UTI in CKD patients.

Materials and methods: A cross-sectional study was done on 1000 of CKD patients attending Nephrology Department of Chattogram Medical College Hospital (CMCH) a tertiary level hospital in Bangladesh during January to December, 2017. Cleancatch midstream urine samples were collected from study populations irrespective of symptoms. Macroscopic and microscopic examinations were done. Urine samples were then inoculated in Blood agar and Mac’Conkey agar and incubated aerobically at 37 °C for 18-24 hours. Microscopic observations and conventional biochemical tests were done to identify the isolated organisms. Significant growth of organisms in urine was defined as UTI. The isolated organisms were tested for antimicrobial susceptibility by using modified Kirby Bauer technique.

Results: The prevalence of UTI was 61.8%. with significant asymptomatic UTI for 28%. Gram-negative organisms were most frequent 564 (93%) with predominant Escherichia coli 399 (64%) followed by Klebsiella 113(18%) and Pseudomonas 39(6%). Among Gram positive isolates, Staphylococcus (6%) was the dominant organism isolated. Regarding antibiotic susceptibility, Gram-negative microorganisms were found to be most sensitive to carbapenem and amikacin whereas Gram-positive microorganisms were most sensitive towards carbapenem, colistin and linezolid.

Conclusion: In CKD patients, asymptomatic UTI was detected significantly. E.coli was found to be predominant organisms and resistant towards most of the studied common antibiotics.

Chatt Maa Shi Hosp Med Coll J; Vol.20 (1); January 2021; Page 41-45
Compulsive Behaviors in the Workplace
Authors: Deciu Valeriu
Published: May 2021

Compulsive behaviors are psychiatric challenges that interfere with the regular life practices of those who exhibit them. This study qualitatively identified compulsive behaviors within three organizations located in no.2 major cities from Romania, aiming to explore their effects on workers' productivity and extended community, including coworkers and employers. To understand the exact behaviors, a literature search was done from Google Scholar to understand examples of compulsive behaviors in the workplace before gathering data from the participants. Using three organizations, from construction materials and adjacent industries, 15 participants were selected and agreed to be interviewed. Further, a survey questionnaire was used to explore the severity and effect of the behaviors on productivity at work. The main results noted workplace compulsive behaviors like repetitive cleanliness, ritualistic behaviors like repetitive ordering or organizing things in a particular manner, persistent repetition of certain words or actions for the perfection of the work assigned, and isolation from other members. The findings from the results entailed an understanding that most compulsive behaviors conflict with established workplace code of conduct. Also, employees confirmed their continued struggle to control the exhibited behaviors. The effects of the behaviors on the employees' productivity and time management were also highlighted. Importantly, most participants confirmed that most employers and coworkers understand their situations and provide social support.
Kuru femur kemiklerinde kollodiyafiz (inklinasyon) açı ile diğer osteometrik ölçümler arasındaki ilişki ve klinik önemi
Authors: AÇAR Gülay , DİGİLLİ Betül
Published: May 2021

Bu çalışmada antropologlar ve ortopedistler için faydalı olacak proksimal ve distal femoral geometriye ilişkin geniş bir morfometrik veri setinin oluşturulması amaçlanmıştır. Femoral morfometri adlî antropoloji alanında cinsiyet ve yaş tespiti için kullanılır. Femur anatomisine ilişkin bu morfometrik bilgi, cerrahî açıdan kalça ve diz artroplastisinde özellikle önemlidir. Çalışmamızda yaşı ve cinsiyeti bilinmeyen 120 (60 sağ, 60 sol) kuru femur kemikleri incelenmiştir. Dijital kumpas ve gonyometre kullanılarak 15 doğrusal ve bir açısal antropometrik parametre değerlendirilmiştir. Ölçüm parametreleri; femur uzunluğu, femur gövde uzunluğu ve genişliği, femur başının çevresi ve dikey çapı, femur boyun çevresi, genişliği, ön ve eksen uzunlukları, intertrokanterik mesafe, kollodiyafiz açı (inklinasyon açısı), fossa intercondylaris genişliği ve yüksekliği, fossa intercondylaris endisi, medial ve lateral kondüllerin genişliği ve bikondüler genişlik olarak belirlenmiştir. Ayrıca femurlar, fossa intercondylaris’in şekline ve endisine göre üç gruba ayrılmıştır. Ölçüm değerleri arasında sağ-sol karşılaştırması açısından anlamlı fark bulunmamıştır (p>0,05). İnklinasyon açısının femur boynu ön ve eksen uzunlukları ile anlamlı negatif korelasyon gösterdiği tespit edilmiştir (r=-0,255, p=0,005; r=-0,190, p=0,038). İnklinasyon açısı dışında diğer proksimal femur parametreleri arasında kuvvetli pozitif korelasyon görülmüştür. Ayrıca, distal femur parametreleri arasında da medial kondül genişliği dışında pozitif korelasyon bulunmuştur. Elde edilen morfometrik verilerin ileride yapılacak antropometrik çalışmalar için referans veri tabanı olarak kullanılabileceği ve kalça ve diz protezlerinin tasarımı açısından cerrahlar için faydalı olabileceği düşüncesindeyiz.
Croatian accentual norm at the beginning of the 21st century (from theory to practice and back)
Authors: Martinović Blaženka
Published: May 2021

Croatian accentual norm is in a constant state of flux. Its stability is impeded, first of all, by two mutually intertwined forces: the nature of the accentual norm, which belongs to speech (dynamic dimension, individual realisation), and the disagreement amongst linguists as to what to record and prescribe (in constant interaction between the stress accent and pitch accent systems). The modern accentual norm is obtained from non-orthoepical manuals, i.e. grammar books, dictionaries, handbooks (which further complicates the clarification of the orthoepical reality). We will conduct a comparative analysis of the approach, in modern handbooks, to accent alternations in morphology, falling accent in non-initial syllables in word formation, post-tonic length, uncertainties regarding lexical stress, etc. Grammar books and dictionaries approach the open questions in different ways and this paper gives an overview of the (systematic and non-systematic) solutions offered by linguists today, with the aim of presenting the dynamics of the codified norm (which carries the label of being “conservative” and “hidebound”). The changes in the modern norm are compared then to usus occurrences, illustrated by a narrower speech corpus – the speech of actors. In their orthoepical research, linguists resort to the speech of radio and television presenters, linguists in specialised radio and television programmes, students of the Croatian language or phonetics, Croatian language teachers, etc., and, more recently, to the speech of actors reading audio books (MP3 files are available at www.lektire.skole.hr). Presenters, teachers and actors have always been perceived as quintessential competent speakers of the standard language, so close observation of their speech as one of the steps in the process of describing and prescribing is the basis of every orthoepical research. Since the modern speech/pronunciation (e-lektira, audio versions of school reading list books available online) has still not been analysed and valorised linguistically/orthoepically, and since it is available to those learning and listening to speech values in this type of material, the paper turns to the corpus with the intention of determining the basic features of pronunciation. Prose texts whose pronunciation has been analysed are those written in or translated into the standard language. Special attention has been given to accent (stress placement and stress shift) and to the prosodic word. Specific pronunciation traits (especially those related to the accentual norm) have been compared to those prescribed in handbooks. Finally, the accentual traits acknowledged by the modern conception of accentual norm and codification were clarified as well as those that are systematically ignored in modern prescription.
ANALISIS INOVASI PEMERINTAHAN DIGITAL VILLAGE DALAM PENINGKATAN PELAYANAN PUBLIK DI NUSA TENGGARA TIMUR
Authors: Banabera Gerry I. S.
Published: May 2021

Penilitian terfokuskan pada analisis inovasi pemerintahan digital village dalam peningkatan pelayanan publik di Kelurahan Naikoten II, Kecamatan Kota Raja, Kota Kupang. Tujuan penilitian ini adalah untuk mengetahui dan menganalisis pelaksanaan inovasi digital village, faktor-faktor apa saja yang mempengaruhinya, dan strategi yang dilakukan dalam mengatasi faktor penghambat pelaksanaan inovasi pemerintah digital village .Teori yang digunakan adalah teori karateristik inovasi yang dikemukakan oleh  Everett M. Roger. Desain penilitian yang digunakan adalah penilitian kualitatif dengan pendekatan deskriptif. Hasil penilitian menunjukan bahwa pelaksanaan inovasi pemerintahan digital village di Kelurahan Naikoten II sejauh ini sudah bisa dikatakan dapat meningkatkan pelayanan publik dengan memanfaatkan sarana, prasarana dan teknologi sehingga dapat menciptakan efektifitas dan efisiensi dalam memberikan pelayanan. Adapun faktor penghambat dalam pelaksanaan inovasi pemerintah digital village dalam meningkatkan pelayanan publik adalah kebergantungan pada 1 (satu) staf/operator komputer untuk mengoperasikan komputer server; sering tering terjadi kerusakan jaringan dan kegagalan pada server yang mengganggu aktivitas pelayanan; masih kurangnya penyesuaian oleh sebagian masyarakat sehingga masih dilayani secara manual; belum adanya anggaran khusus dari Pemerintah Daerah yang; sering terjadi rotasi atau mutasi pegawai yang akan mempengarauhi proses pelayanan; dan menurunnya tingkat disiplin pegawai karena menurunnya beban kerja dengan adanya inovasi ini. Oleh karena itu strategi yang perlu dilakukan oleh pemeritah daerah adalah membangun kerja sama antara Pemerintah Daerah dan pihak ketiga untuk pengambangan inovasi digital village di Kelurahan Naikoten II serta penerapannya di kelurahan lain lingkup pemerintah Kota Kupang dan menyusun rencana penetapan inovasi digital village untuk menjadi program tetap pemerintah sebagai standar pelakasanaan pelayanan kelurahan lingkup pemerintah Kota Kupang.
IMPLEMENTASI KEBIJAKAN PERATURAN MENTERI SOSIAL NOMOR 1 TAHUN 2018 TENTANG PROGRAM KELUARGA HARAPAN (PKH) OLEH DINAS SOSIAL DI KECAMATAN PANGALENGAN KABUPATEN BANDUNG
Authors: Adiwilaga Rendy , Widiyaningrum Widdy Yuspita , Hasanah Dera Izhar
Published: May 2021

Program Keluarga Harapan (PKH) adalah program pemberian uang tunai kepada Rumah Tangga Sangat Miskin (RTSM) berdasarkan persyaratan dan ketentuan yang telah ditetapkan dengan melaksanakan kewajibannya. Program semacam ini secara internasional dikenal sebagai program conditional cash transfers (CCT) atau program Bantuan Tunai Bersyarat. Persyaratan tersebut dapat berupa kehadiran di fasilitas pendidikan (misalnya bagi anak usia sekolah), ataupun kehadiran di fasilitas kesehatan (misalnya bagi anak balita, atau bagi ibu hamil) dengan tujuannya untuk meningkatkan kualitas hidup keluarga miskin dan rentan melalui peningkatan aksesibilitas terhadap layanan kesehatan, pendidikan, dan kesejahteraan sosial, perlu program perlindungan sosial yang terencana, terarah, dan berkelanjutan yang tertuang dalam Peraturan Menteri Sosial Nomor 1 Tahun 2018 tentang Program Keluarga Harapan (PKH) diuji berdasarkan teori Implementasi Kebijakan dari Edward III. Pendekatan dalam penelitian ini menggunakan penelitian kualitatif menggunakan latar alamiah dengan maksud menafsirkan fenomena yang terjadi dan dilakukan dengan jalan melibatkan berbagai metode yang ada melalui wawancara, pengamatan, dan pemanfaatan dokumen. Dengan melakukan penelitian diharapkan akan memberikan kontribusi untuk khalayak khususnya dalam Implementasi Kebijakan Peraturan Menteri Sosial

Nomor 1 Tahun 2018 Tentang Program Keluarga Harapan (PKH) Oleh Dinas Sosial Bidang Perlindungan Jaminan Sosial Melalui Pendampingan PKH dalam Meningkatkan Kualitas Hidup Keluarga Miskin dan Rentan di Kecamatan Pangalengan Kabupaten Bandung.
Social Support of Parents on Medication Adherence to Tuberculosis Patients in Children
Authors: Ningtyias Farida Wahyu , Nafikadini Iken , Hamdalah Afif , Muldayani Wahyu
Published: May 2021

Adherence to taking this medication is needed in all diseases, especially TB disease, because this disease requires extra supervision in its treatment. Adherence to medication behavior is basically influenced by several factors, one of which is social support from those closest to the patient. Support can be obtained from the patient's family (father and mother), who always monitor the progress of patients. The 4 basic forms of social support, namely emotional support, instrumental support, informative support and reward support. This was qualitative research. Focus group discussion with 12 informants used for collected data. Results of this research showed that parents gave social supports i.g emotional support, instrumental support, informative support and reward support which related with medication adherence.

Keywords: social support; parents; medication adherence; tuberculosis; children
Gondomono (Hedycium spicatum) Ethanol Exstract Anti-Proliferation, Apoptosis and P53 Cancer Cell Line
Authors: Rahman Nur
Published: May 2021

The incidence of cancer from year to year continues to increase. Some of the causes of this incident include an unhealthy lifestyle, smoking, a diet high in fat and low in fiber. The Gondomono plant (Hedychium spicatum) are the most studied species. Interesting compounds have been identified like coronarin D, which possesses antibacterial, antifungal and antitumor activities, as well as isocoronarin D, linalool and villosin that exhibit better cytotoxicity towards tumor cell lines than the reference compounds used, with villosin not affecting the non-tumor cell line. This study aims to obtain scientific evidence that Gondomono extract (Hedychium spicatum) is proven to be anti-cancer. The impact obtained will be utilized by local Indonesian plants that can be processed or produced as functional food and herbal medicine for anti-cancer bioactivity toxicity with various tests including the making gondomono (Hedycium spicatum) flour, ethanol extraction method, insilico analysis and Gas Chromatography-Mass Spectrometry (GC-MS) analysis, then the second stage test, namely the MTT test, P53 test and apoptosis test. The research design was experimental. Gondomono extract when compared to anticancer ingredients was indeed very far away, gondomono extract was starting to be able to act as apoptosis, it requires a fairly high concentration, from 200 to 400 ppm. As conclusion, the higher the dose of gondomono extract, the higher the expression of p53 protein, the higher. Gondomono extract as a cancer cell killer requires a minimum dose of 368.51 ppm.

Keywords: gondomono; Hedycium spicatum; anti-proliferasi; cancer cell line
Baseline Conservative and Surgical Management in the Treatment of NSAID-Exacerbated Respiratory Disease
Authors: Sillanpää Saara , Numminen Jura
Published: May 2021

Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) is a chronic medical condition that includes asthma, chronic rhinosinusitis with nasal polyposis, and hypersensitivity to aspirin and other NSAIDs. Eosinophilic inflammation in the upper and lower airways is treated with local corticosteroids, repeated antibiotics, oral corticosteroid courses, endoscopic sinus surgery, and in some cases aspirin treatment after desensitization (ATAD). Nevertheless, the disease may be uncontrolled and it has a great impact on quality of life. A better understanding of the pathomechanisms of the disease and the development of medications that target type 2 inflammation mediators may have a crucial role in achieving better disease control in patients with N-ERD.
Microalgal Biodiesel Production: Realizing the Sustainability Index
Authors: Patnaik Reeza , Mallick Nirupama
Published: May 2021

Search for new and renewable sources of energy has made research reach the tiny little tots, microalgae for the production of biodiesel. But despite years of research on the topic, a definitive statement, declaring microalgae as an economically, environmentally, and socially sustainable resource is yet to be seen or heard of. With technological and scientific glitches being blamed for this delay in the progress of the production system, an assessment of the sustainability indices achieved so far by the microalgal biodiesel is important to be done so as to direct future research efforts in a more coordinated manner to achieve the sustainability mark. This article provides a review of the current economic, environmental, and social status of microalgal biodiesel and the strategies adopted to achieve them, with suggestions to address the challenges faced by the microalgal biodiesel production system.
Morphological and Rheological Guided Design for the Microencapsulation Process of Lactobacillus paracasei CBA L74 in Calcium Alginate Microspheres
Authors: Di Natale Concetta , Lagreca Elena , Panzetta Valeria , Gallo Marianna , Passannanti Francesca , Vitale Michele , Fusco Sabato , Vecchione Raffaele , Nigro Roberto , Netti Paolo
Published: May 2021

The intestinal microbiota is a real ecosystem composed of several bacterial species and a very huge amount of strains that through their metabolic activities play a crucial role in the development and performance of the immune system and other functions. Microbiota modulation by probiotics establishes a new era into the pharmaceutical and healthcare market. Probiotics play, in fact, an important role in helping and sustaining human health, but in order to produce benefits, their viability must be preserved throughout the production process up to consumption, and in addition, their bioactivity required to be safeguarded while passing through the gastrointestinal tract. In this frame, encouraging results come from encapsulation strategies that have proven to be very promising in protecting bacteria and their viability. However, specific effort has to be dedicated to the design optimization of the encapsulation process and, in particular, to the processing parameters that affect capsules microstructure. Herein, focusing on calcium alginate microspheres, after a preliminary selection of their processing conditions based on size distribution, we implemented a micro-rheological analysis, by using the multiple-particle tracking technique, to correlate the inner microstructure to the selected process conditions and to the viability of the Lactobacillus paracasei CBA L74. It was assessed that the explored levels of cross-linking, although changing the microorganism constriction, did not affect its viability. The obtained results confirm how this technology is a promising and a valid strategy to protect the microorganism viability and ensure its stability during the production process.
Boron Oxide Nanoparticles Exhibit Minor, Species-Specific Acute Toxicity to North-Temperate and Amazonian Freshwater Fishes
Authors: MacCormack Tyson J. , Gormley Patrick T. , Khuong B. Ninh , Adams Olivia A. , Braz-Mota Susana , Duarte Rafael M. , Vogels Christopher M. , Tremblay Luc , Val Adalberto L. , Almeida-Val Vera M. F. , Westcott Stephen A.
Published: May 2021

Boron oxide nanoparticles (nB2O3) are manufactured for structural, propellant, and clinical applications and also form spontaneously through the degradation of bulk boron compounds. Bulk boron is not toxic to vertebrates but the distinctive properties of its nanostructured equivalent may alter its biocompatibility. Few studies have addressed this possibility, thus our goal was to gain an initial understanding of the potential acute toxicity of nB2O3 to freshwater fish and we used a variety of model systems to achieve this. Bioactivity was investigated in rainbow trout (Oncorhynchus mykiss) hepatocytes and at the whole animal level in three other North and South American fish species using indicators of aerobic metabolism, behavior, oxidative stress, neurotoxicity, and ionoregulation. nB2O3 reduced O. mykiss hepatocyte oxygen consumption (ṀO2) by 35% at high doses but whole animal ṀO2 was not affected in any species. Spontaneous activity was assessed using ṀO2 frequency distribution plots from live fish. nB2O3 increased the frequency of high ṀO2 events in the Amazonian fish Paracheirodon axelrodi, suggesting exposure enhanced spontaneous aerobic activity. ṀO2 frequency distributions were not affected in the other species examined. Liver lactate accumulation and significant changes in cardiac acetylcholinesterase and gill Na+/K+-ATPase activity were noted in the north-temperate Fundulus diaphanus exposed to nB2O3, but not in the Amazonian Apistogramma agassizii or P. axelrodi. nB2O3 did not induce oxidative stress in any of the species studied. Overall, nB2O3 exhibited modest, species-specific bioactivity but only at doses exceeding predicted environmental relevance. Chronic, low dose exposure studies are required for confirmation, but our data suggest that, like bulk boron, nB2O3 is relatively non-toxic to aquatic vertebrates and thus represents a promising formulation for further development.
An Overview of the Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy
Authors: Cao Yu , Yang Zhao , Chen Ying , Jiang Shuai , Wu Zhen , Ding Baoping , Yang Yang , Jin Zhenxiao , Tang Haifeng
Published: May 2021

Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by its complex pathogenesis, higher risk of mortality, and the lack of effective diagnosis and treatment methods. Many studies focus on the diagnosis and treatment of diabetes mellitus (DM) and have reported that the pathophysiology of DN is very complex, involving many molecules and abnormal cellular activities. Given the respective pivotal roles of NF-κB, Nrf2, and TGF-β in inflammation, oxidative stress, and fibrosis during DN, we first review the effect of posttranslational modifications on these vital molecules in DN. Then, we describe the relationship between these molecules and related abnormal cellular activities in DN. Finally, we discuss some potential directions for DN treatment and diagnosis. The information reviewed here may be significant in the design of further studies to identify valuable therapeutic targets for DN.
Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea
Authors: Durán Alonso María Beatriz , Vendrell Victor , López-Hernández Iris , Alonso María Teresa , Martin Donna M. , Giráldez Fernando , Carramolino Laura , Giovinazzo Giovanna , Vázquez Enrique , Torres Miguel , Schimmang Thomas
Published: May 2021

Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea. Meis2 is expressed in several tissues required for inner ear induction and in non-sensory tissue of the cochlear duct. Global inactivation of Meis2 in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of Meis2 reveal that its expression in the hindbrain is essential for otic vesicle formation. Inactivation of Meis2 in the inner ear itself leads to an aberrant coiling of the cochlear duct. By analyzing transcriptomes obtained from Meis2 mutants and ChIPseq analysis of an otic cell line, we define candidate target genes for Meis2 which may be directly or indirectly involved in cochlear morphogenesis. Taken together, these data show that Meis2 is essential for inner ear formation and provide an entry point to unveil the network underlying proper coiling of the cochlear duct.
Tyrosine-Protein Phosphatase Non-receptor Type 9 (PTPN9) Negatively Regulates the Paracrine Vasoprotective Activity of Bone-Marrow Derived Pro-angiogenic Cells: Impact on Vascular Degeneration in Oxygen-Induced Retinopathy
Authors: Desjarlais Michel , Ruknudin Pakiza , Wirth Maëlle , Lahaie Isabelle , Dabouz Rabah , Rivera José Carlos , Habelrih Tiffany , Omri Samy , Hardy Pierre , Rivard Alain , Chemtob Sylvain
Published: May 2021

Background and Aim

Insufficient post-ischemic neovascularization is an initial key step in the pathogenesis of Oxygen-Induced Retinopathy (OIR). During neovascularization, pro-angiogenic cells (PACs) are mobilized from the bone marrow and integrate into ischemic tissues to promote angiogenesis. However, the modulation of PAC paracrine activity during OIR and the specific mechanisms involved remain to be explored. Because Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) is reported to be a negative regulator of stem cell differentiation and angiogenesis signaling, we investigated its effect on PAC activity in the context of OIR.

Methods and Results

In a rat model of OIR, higher levels of PTPN9 in the retina and in bone marrow derived PACs are associated with retinal avascular areas, lower levels of the mobilization factor SDF-1 and decreased number of CD34+/CD117+/CD133+ PACs. PACs exposed ex vivo to hyperoxia display increased PTPN9 expression, which is associated with impaired ability of PAC secretome to promote angiogenesis ex vivo (choroidal vascular sprouting) and in vitro (endothelial cell tubule formation) compared to the secretome of PACs maintained in normoxia. Suppression of PTPN9 (using siRNA) increases VEGF and SDF-1 expression to normalize PAC secretome during hyperoxia, leading to restored angiogenic ability of PAC secretome. Moreover, endothelial cells exposed to the secretome of siPTPN9-treated PACs expressed increased levels of activated form of VEGF receptor 2 (VEGFR2). In the rat model of OIR, intravitreal injection of secretome from siPTPN9-treated PACs significantly reduced retinal vaso-obliteration; this was associated with higher retinal levels of VEGF/SDF-1, and increased recruitment of PACs (CD34+ cells) to the retinal and choroidal vessels.

Conclusion

Our results suggest that hyperoxia alters the paracrine proangiogenic activity of BM-PACs by inducing PTPN9, which can contribute to impair post-ischemic revascularization in the context of OIR. Targeting PTPN9 restores PAC angiogenic properties, and provide a new target for vessel integrity in ischemic retinopathies.
Coordinated Formation of IMPDH2 Cytoophidium in Mouse Oocytes and Granulosa Cells
Authors: Ni Shiwen , Zhang Teng , Zhou Chenmin , Long Min , Hou Xuan , You Liji , Li Hui , Shi Lanying , Su You-Qiang
Published: May 2021

Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme catalyzingde novobiosynthesis of guanine nucleotides, aggregates under certain circumstances into a type of non-membranous filamentous macrostructure termed “cytoophidium” or “rod and ring” in several types of cells. However, the biological significance and underlying mechanism of IMPDH assembling into cytoophidium remain elusive. In mouse ovaries, IMPDH is reported to be crucial for the maintenance of oocyte–follicle developmental synchrony by providing GTP substrate for granulosa cell natriuretic peptide C/natriuretic peptide receptor 2 (NPPC/NPR2) system to produce cGMP for sustaining oocyte meiotic arrest. Oocytes and the associated somatic cells in the ovary hence render an exciting model system for exploring the functional significance of formation of IMPDH cytoophidium within the cell. We report here that IMPDH2 cytoophidium formsin vivoin the growing oocytes naturally andin vitroin the cumulus-enclosed oocytes treated with IMPDH inhibitor mycophenolic acid (MPA). Inhibition of IMPDH activity in oocytes and preimplantation embryos compromises oocyte meiotic and developmental competences and the development of embryos beyond the 4-cell stage, respectively. IMPDH cytoopidium also formsin vivoin the granulosa cells of the preovulatory follicles after the surge of luteinizing hormone (LH), which coincides with the resumption of oocyte meiosis and the reduction of IMPDH2 protein expression. In cultured COCs, MPA-treatment causes the simultaneous formation of IMPDH cytoopidium in cumulus cells and the resumption of meiosis in oocytes, which is mediated by the MTOR pathway and is prevented by guanosine supplementation. Therefore, our results indicate that cytoophidia do form in the oocytes and granulosa cells at particular stages of development, which may contribute to the oocyte acquisition of meiotic and developmental competences and the induction of meiosis re-initiation by the LH surge, respectively.