bluuebunny/crossref_metadata_2025 huggingface dataset:
Possible signals of poleward surface ocean heat transport, of Arctic basal ice melt, and of the twentieth century solar maximum in the 1904-2012 Isle of Man daily timeseries
Authors: Matthews J. B. , Matthews J. B. R.
Published: January 2014

Abstract. This is the second of two papers on observational timeseries of top of ocean heat capture. The first reports hourly and daily meridional central tropical Pacific top 3 m timeseries showing high Southern Hemisphere evaporation (2.67 m yr−1) and Northern Hemisphere trapped heat (12 MJ m−2 day−1). We suggested that wind drift/geostrophic stratified gyre circulation transported warm water to the Arctic and led to three phases of Arctic basal ice melt and fluxes of brackish nutrient-rich waters to north Atlantic on centennial timescales. Here we examine daily top metre 1904–2012 timeseries at Isle of Man west coast ~54° N for evidence of tropical and polar surface waters. We compare these to Central England (CET) daily land-air temperatures and to Arctic floating ice heat content and extent. We find three phases of ocean surface heating consistent with basal icemelt buffering greenhouse gas warming until a regime shift post-1986 led to the modern surface temperature rise of ~1 °C in 20 yr. Three phases were: warming +0.018 °C yr−1 from 1904–1939, slight cooling −0.002 °C yr−11940–86 and strong warming +0.037 °C yr−1 1986–2012. For the same periods CET land-air showed: warming +0.015 °C yr−1, slight cooling −0.004 °C yr−1, about half SST warming at +0.018 °C yr−1. The mid-century cooling and a 1959/1963 hot/cold event is consistent with sunspot/solar radiation maximum 1923–2008 leading to record volumes of Arctic ice meltwater and runoff that peaked in 1962/3 British Isles extreme cold winter. The warming Arctic resulted in wind regime and surface water regime shifts post 1986. This coincides with the onset of rapid Arctic annual ice melt. Continued heat imbalance is likely to lead to tidewater glacier basal icemelt and future sealevel rise after remaining relatively stable over 4000 yr. Our work needs confirmation by further fieldwork concentrating on the dynamics and thermodynamics of ocean top 3 m that controls the 93 % anthropogenic global warming in the oceans. This may be done most cost-effectively through focussed multidisciplinary scientific research adaptively managed and funded.
Emerging Infectious Diseases, Antimicrobial Resistance and Millennium Development Goals: Resolving the Challenges through One Health
Authors: Asokan G. V. , Kasimanickam R. K.
Published: January 2014

Most emerging infectious diseases are zoonoses, which could severely hamper reaching the targets of millennium development goals (MDG). Five out of the total eight MDG’s are strongly associated with the Emerging Infectious Diseases (EIDs). Recent emergence and dissemination of drug-resistant pathogens has accelerated and prevent reaching the targets of MDG, with shrinking of therapeutic arsenal, mostly due to antimicrobial resistance (AMR). World Health Organization (WHO has identified AMR as 1 of the 3 greatest threats to global health.Until now, methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) have been observed in hospital-acquired infections. In India, within a span of three years, New Delhi metallo-β-lactamase prevalence has risen from three percent in hospitals to twenty- fifty percent and is found to be colistin resistant as well. Routine use of antimicrobials in animal husbandry accounts for more than 50% in tonnage of all antimicrobial production to promote growth and prophylaxis. This has consequences to human health and environmental contamination with a profound impact on the environmental microbiome, resulting in resistance. Antibiotic development is now considered a global health crisis. The average time required to receive regulatory approval is 7.2 years. Moreover, the clinical approval success is only 16%. To overcome resistance in antimicrobials, intersectoral partnerships among medical, veterinary, and environmental disciplines, with specific epidemiological, diagnostic, and therapeutic approaches are needed. Joint efforts under “One Health”, beyond individual professional boundaries are required to stop antimicrobial resistance against zoonoses (EID) and reach the MDG.
Fragile Identities, Capable Selves
Authors: Savage Roger W.H.
Published: January 2014

The spotlight that Martha Nussbaum turns on the plight of women in developing nations brings the disproportion between human capabilities and the opportunities to exercise them sharply into focus. Social prejudices, economic discrimination, and deep-seated traditions and attitudes all harbor the seeds of systemic injustices within governing policies and institutions. The refusal on the part of a dominant class to recognize the rights and claims of subaltern individuals and groups has both symbolic and material consequences. The power that one group exercises over another brings the refusal to recognize the rights and claims of others to the fore. Thanks to the moral priority that Paul Ricoeur accords to the victim against such refusals, I tie the fragility of identity to the idea of justice’s federating force. This federating force, I therefore argue, accompanies the struggle for recognition among capable human beings.
Compétences et moyens de l’homme capable à la lumière de l’incapacité
Authors: Wolff Ernst
Published: January 2014

Depuis Soi-même comme un autre, Ricœur place la notion de capacité ou du “je peux” au cœur de l’herméneutique du soi. Autant il explore l’éventail des capacités, autant la notion même de capacité reste indéterminée d’un point de vue que l’on peut appeler “technique.” La thèse que je défends dans cet article est que l’herméneutique de l’homme capable exige un développement de sa dimension technique, c’est-à-dire une réflexion sur les compétences et les moyens du “je peux.” Afin de soutenir cette thèse, cinq dimensions de l’incapacité de l’homme capable sont explorées afin d’affirmer que l’incapacité est l’horizon pratique de l’action de l’homme capable. Ensuite, la tension entre pouvoir et non-pouvoir est décrite comme la finitude originaire de l’acteur humain. Cette conclusion nous permet de démontrer que l’homme capable-incapable révèle l’homme technique et cela sur toute la gamme des interactions sociales.
La Reconnaissance, la justice, et la vie bonne
Authors: Reagan Charles
Published: January 2014

Cet article traite des notions de reconnaissance, de justice, et de vie bonne, d'abord, séparément, et ensuite comme un réseau où elles se renforcent et s’impliquent.  Je commence en abordant les significations de “la reconnaissance,” et en prenant comme texte de référence  Parcours de la reconnaissance de Paul Ricoeur. On peut distinguer la reconnaissance au sens épistémologique, la reconnaissance de soi, la reconnaissance d’autrui sur le plan social et politique. Dans un second temps, je concentre mon attention sur le sens de la justice, dans le sens de la justice judiciaire, c’est-à-dire toute la structure des cours (criminel et civil) et le système pénal et policier. Enfin, je décris les exigences sociales, légales et politiques pour accéder à "la vie bonne" dans un pays moderne.  Des systèmes de transport, d'éducation, marchand, bancaire, etc. sont aussi requis pour atteindre  "la vie bonne".  L'importance de ces éléments est particulièrement saillante lorsque nous observons ce qui arrive dans des pays en pleine guerre civile comme la Syrie, ou des pays détruits par des forces naturelles, comme le tremblement de terre en Haiti.  Ma conclusion est que la "vie bonne" exige la reconnaissance de l’un et de l’autre et d’un gouvernement légitime ainsi que des systèmes de justice.
Introduction
Authors: Chinello Chiara , Pedone Claudia , Romele Alberto
Published: January 2014

The English introduction to Volume 4, no. 2 (2013).
Review of Uchida, Kesao 2012 Subekaraku 60-ten-shugi
Authors: Connor Blaine P.
Published: January 2014

This reviews a biographical profile of Omura Kyoichiro, who headed Shiseido's advertising department in the 1970s and 1980s, by one of his colleagues.
Biotechnology Venture Investing and Neurodegenerative Medicine: Promise of New Approaches to Cure an Ailing Model
Authors: Riley Dushon DeVere , Cochran Mark
Published: January 2014

Neurodegenerative diseases are one of the leading public health challenges of the next 50 years. Pharmaceutical therapies have traditionally targeted the later stages of neurodegenerative diseases; however, this strategy - as the recent failures of clinical trials for Alzheimerâ€™s drugs have highlighted - has been unsuccessful. Venture capital has underperformed as well during this time, as many new companies have been unable to maintain growth once they reach the public market and have produced less than desirable returns. As a result, venture capitalists have opted for later-stage financing. Nevertheless, new technologies are being developed to answer the question of how to best address neurodegeneration. New tools of detection will allow for much earlier diagnosis and a much greater chance of discovering and applying effective treatments. Realizing that genetic knowledge is insufficient to produce innovative treatments for neurodegenerative diseases, scientists have begun to apply the genetic knowledge attained towards a future of individualized treatments. As these new tools of detection converge with an increased ability to create very precise individual solutions, the risk of successful future investments should come down and provide the potential for outsized returns that have traditionally governed the venture capital financial model.
Socio-Agricultural Correlation and Regionalization: A Case of the Districts of Pakistan
Authors: Razzaq Ahmed  , Khalida Mahmood  , Anila Kausar
Published: January 2014

The main economic activity of a large segment of population in Pakistan is agriculture. The contrasting pattern of topography and uneven distribution of resources create a wide difference in socio-agricultural relationship among the different administrative districts of the country. The study aims to investigate the correlation based on a number of variables extracted from different sectors of Pakistan’s agriculture and social infrastructure. In order to study the regionalization multivariate analysis has been done for hundred districts of Pakistan. The results produced, show sharp variation of regional disparity among the different districts of Pakistan. A clear cut longitudinal east-west divide is visible from the outcome of the study. The provinces of Punjab and Sindh, consisting of fertile plains of river Indus and its tributaries stand out with better socio-agricultural correlation. The western provinces of Khyber Pakhtoonkhwa and Balochistan, surrounded by mountains and plateau depict a deprived scene in terms of socio-agricultural well-being. In Pakistan districts are very vital for resource planning and development. These administrative units have a mix of both rural and urban activities that is why this study becomes more significant for future district planning decisions.
A metamorfose dos sistemas de informação na era da computação móvel
Authors: Barroca Filho Itamir de Morais , Aquino Junior Gibeon Soares de
Published: January 2014

Considerando a era da computação móvel percebemos que os sistemas de informação estão passando por um processo de metamorfose para possibilitar que seus usuários utilizem novas formas de acessos às informações a partir de dispositivos móveis. Isso se deve principalmente ao aumento da popularidade de dispositivos como smartphones e tablets. Impulsionado por esse novo cenário de computação, que está mudando velhos hábitos e criando novas maneiras da sociedade acessar informações que até então só eram acessíveis através de computadores tradicionais, crescem as demandas por aplicações móveis corporativas (Mobile Enterprise Application – MEA). Esse aumento é ocasionado pela necessidade das empresas garantirem aos seus clientes novas formas de interações com seus serviços. Com isso, esse artigo tem o objetivo de apresentar um processo denominado MetamorphosIS, que provê um conjunto de atividades categorizadas em abordagens negociais, técnicas e de interface gráfica para auxiliar o desenvolvimento de aplicações mobile baseadas em sistemas de informações existentes. Em seguida o artigo ainda descreve o aplicativo SIGAA mobile, que é um estudo de caso da aplicação das atividades descritas nesse processo em um sistema de informação denominado SIGAA.
Intenção e padrão de uso do Moodle por alunos do EAD: uma abordagem da teoria unificada de aceitação e uso da tecnologia (UTAUT)
Authors: Pereira Fernando Antonio de Melo , Ramos Anatália Saraiva Martins , Nogueira Cinthya Muyrielle da Silva , Gomes Anna Cecília Chaves , Mól Anderson Luiz Rezende
Published: January 2014

Utilizando o UTAUT, esta pesquisa tem por objetivo identificar as relações entre os construtos expectativa de desempenho, expectativa de esforço, influência social e condições facilitadoras com a intenção de uso e o padrão de uso do sistema Moodle com estudantes de um curso superior de administração pública de uma universidade federal. A técnica utilizada para a análise dos dados foi a modelagem de equações estruturais (SEM), por meio do método dos mínimos quadrados parciais por modelagem de caminhos. Foi comprovado que a intenção de uso é explicada pela expectativa de desempenho do usuário. Já o padrão de uso é explicado pela intenção de uso e pelas condições facilitadoras. Os resultados encontrados revelam a importância de oferecer uma plataforma virtual de ensino intuitiva e fácil de utilizar, bem como que ofereça um sistema de suporte online. Com a adoção do UTAUT com estudantes de ensino superior à distância, o modelo é aplicado em mais um ambiente de aceitação e uso de tecnologia, ampliando os contextos em que o modelo pode ser aplicado com sucesso.
Rádio universitária web: reflexões sobre um modelo em construção
Authors: Figueiredo Carolina Dantas de
Published: January 2014

O conceito de web rádio e as operações envolvidas no processo de implementação deste tipo de rádio estão em constante elaboração, no que se pode chamar de midiamorfose ou radiomorfose. O presente artigo visa discutir brevemente a radiomorfose do rádio AM para a web rádio, tentando conceituar este último termo no contexto da implantação da Rádio Universitária Web da Universidade Federal de Pernambuco.
Terceirização de sistemas de informação em Maceió: uma visão do provedor de serviços
Authors: Pereira Lucas Falcão , Tenório Michael Cabral Melville de Souza , Cunha Mônica Ximenes Carneiro da
Published: January 2014

Este artigo tem como objetivo apresentar os resultados iniciais de uma pesquisa sobre o mercado de terceirização de sistemas de informação, em Maceió, que foi realizada com o intuito de conhecer a realidade das empresas prestadoras desses serviços na cidade, especialmente aquelas que desenvolvem sistemas de informação. O artigo inicia com uma breve revisão bibliográfica sobre terceirização. Em seguida apresenta os resultados preliminares das entrevistas com profissionais que estão ou estiveram à frente de entidades responsáveis pela organização de empresas prestadoras de serviços, sejam em arranjos produtivos locais ou associações, bem como com gestores de empresas fornecedoras de serviços de sistemas de informação em Maceió.
Charms In Slovenian Culture
Authors: Babič Saša
Published: January 2014

Nowadays, there only remains a small fraction of charms that used to exist in Slovenia. Charms seem to have become a little known relic of Slovenian culture. Despite this, some healing charms have been preserved and even published in research works by Ivan Grafenauer and Milan Dolenc. The most widely known charms in Slovenia include charms for snakebite, sprain, toothache, cramp, fever, and red rash. In those charms there are obvious German influences, though some charms still show Slavic roots. Charms are a genre that has not been studied by the Slovenian researchers as intensively as other traditional genres, like narratives. We will introduce the main charm types and their characteristics in the Slovenian culture.
Folk narrative in the modern: Unity and diversity
Authors: Timotin Emanuela
Published: January 2014

Charms Symposium, The 16th Congress of the International Society for Folk Narrative Research, "Folk Narrative in the Modern: Unity and Diversity" (June 25–30, 2013, Vilnius, Lithuania) (Emanuela Timotin), pp. 141-143.
The CrIMSS EDR Algorithm: Characterization, Optimization, and Validation
Authors: Divakarla Murty , Barnet Christopher , Liu Xu , Gu Degui , Wilson Michael , Kizer Susan , Xiong Xiaozhen , Maddy Eric , Ferraro Ralph , Knuteson Robert , Hagan Denise , Ma Xia‐lin , Tan Changyi , Nalli Nicholas , Reale Anthony , Mollner Andrew K , Yang Wenze , Gambacorta Antonia , Feltz Michelle , Iturbide‐Sanchez Flavio , Sun Bomin , Goldberg Mitch
Published: January 2014

The Cross‐track Infrared Sounder (CrIS) and the Advanced Technology Microwave Sounder (ATMS) instruments aboard the Suomi National Polar‐orbiting Partnership satellite provide high‐quality hyperspectral infrared and microwave observations to retrieve atmospheric vertical temperature and moisture profiles (AVTP and AVMP) and many other environmental data records (EDRs). The official CrIS and ATMS EDR algorithm, together called the Cross‐track Infrared and Microwave Sounding Suite (CrIMSS), produces EDR products on an operational basis through the interface data processing segment. The CrIMSS algorithm group is to assess and ensure that operational EDRs meet beta and provisional maturity requirements and are ready for stages 1–3 validations. This paper presents a summary of algorithm optimization efforts, as well as characterization and validation of the AVTP and AVMP products using the European Centre for Medium‐Range Weather Forecasts (ECMWF) analysis, the Atmospheric Infrared Sounder (AIRS) retrievals, and conventional and dedicated radiosonde observations. The global root‐mean‐square (RMS) differences between the CrIMSS products and the ECMWF show that the AVTP is meeting the requirements for layers 30–300 hPa (1.53 K versus 1.5 K) and 300–700 hPa (1.28 K versus 1.5 K). Slightly higher RMS difference for the 700 hPa‐surface layer (1.78 K versus 1.6 K) is attributable to land and polar profiles. The AVMP product is within the requirements for 300–600 hPa (26.8% versus 35%) and is close in meeting the requirements for 600 hPa‐surface (25.3% versus 20%). After just one year of maturity, the CrIMSS EDR products are quite comparable to the AIRS heritage algorithm products and show readiness for stages 1–3 validations.
Double effort: Parental behavior of wild Azara's owl monkeys in the face of twins
Authors: Huck Maren , Van Lunenburg Mari , Dávalos Victor , Rotundo Marcelo , Di Fiore Anthony , Fernandez‐Duque Eduardo
Published: January 2014

In species of mammals that habitually bear single offspring, like most anthropoid primates, the occurrence of twins is expected to impose considerable energetic costs on the caretakers. The question then arises of how caregivers cope with the potentially increased costs of raising twins. These increased costs should lead to differing developmental rates in twins when compared to singletons, and/or to changes in the caregivers' behavior. Likewise, time budgets of parents of singletons are expected to differ from those of adults without offspring. Additionally, if twinning was an adaptive response to favorable ecological conditions, it should be more likely in years with high food abundance. Following the birth in 2011 of two sets of twins in a wild population of pair‐living Azara's owl monkeys (Aotus azarae) in Northern Argentina, we used long‐term demographic, behavioral, and phenological data to compare (a) the proportion of time that singleton and twin infants were carried by either parent; (b) adult time budgets and ranging behavior in groups with zero, one, or two infants; and (c) the availability of food in 2011 with food availability in other years. Twins, like singletons, were carried nearly exclusively by the male, and they were carried slightly more than singletons, suggesting a relatively inflexible pattern of infant care in the species. Time budgets showed that twin parents foraged more and moved less than singleton parents or groups without infants, despite the fact that phenological data indicate that fruit availability in 2011 was not substantially higher than in some of the other years. Overall, twinning thus presumably increased costs to breeders, especially males, but its effect on animals' long‐term reproductive success remains unclear. Am. J. Primatol. 76:629–639, 2014. © 2014 Wiley Periodicals, Inc.
Dihydroartemisinin (DHA) Treatment Causes an Arrest of Cell Division and Apoptosis in Rat Embryonic Erythroblasts in Whole Embryo Culture
Authors: Posobiec Lorraine M. , Clark Robert L. , Bushdid Paul B. , Laffan Susan B. , Wang Kai‐Fen , White Tacey E. K.
Published: January 2014

Within 24 hr after oral administration of the antimalarial artesunate to rats on Day 10 or 11 postcoitum (pc), there is depletion of embryonic erythroblasts (EEbs), leading to embryo malformation and death. The proximate agent is dihydroartemisinin (DHA), the primary metabolite. We investigated the causes of EEb depletion by evaluating effects of DHA on EEbs in whole embryo culture (WEC). Rat embryos cultured starting on Day 9 pc were treated with 1 or 7 μM DHA for 24 hr starting after 19 hr of culture (∼Day 10 pc) and for 2 to 12 hr starting after 43 hr of culture (∼Day 11 pc). DHA effects indicating the depletion of EEbs were paling of the visceral yolk sac and reductions in visible blood cells, H&E‐stained normal (Type II or III) EEbs, and dividing (BrdU‐stained) EEbs. DHA‐induced abnormal cell division was indicated by increases in symmetric and asymmetric binuclear cells. DHA‐induced apoptosis was indicated by increases in TUNEL‐ and Caspase‐3‐positive cells and EEbs with fragmented nuclei. In addition, although the overall number of EEbs was decreasing, DHA caused increases in the numbers of circulating early‐stage (Type I or earlier) EEbs that could not be accounted for by cell division, suggesting the release of new, less sensitive erythroblasts from the yolk sac. In summary, treatment of Day 10 or 11 pc rat embryos with DHA in WEC resulted in defective and arrested cell division in EEbs followed by apoptosis, suggesting a mechanism for their depletion after artesunate treatment in vivo.
Epoxidharzbeschichtete Bewehrung
Authors: Zintel Marc , Angst Ueli , Keßler Sylvia , Gehlen Christoph
Published: January 2014

Um die Korrosion von Stahl in Beton infolge Chlorideinwirkung zu ver‐ oder zumindest zu behindern, werden bisher vornehmlich in Nordamerika beachtliche Mengen epoxidharzbeschichteter Bewehrung (ECR) eingesetzt. Die Wirkungsweise und damit das Korrosionsschutzpotenzial von ECR werden in der Wissenschaft jedoch zum Teil kontrovers diskutiert. Nicht zuletzt aufgrund fehlender Informationen über das Langzeitverhalten von ECR fand bisher kein nachhaltiger Technologietransfer nach Deutschland bzw. Europa statt. Nichtsdestotrotz wurde in den Jahren 1989 und 1991 diese Art des Korrosionsschutzes erstmalig in zwei Pilotprojekten (Brückenbauwerke) in der Schweiz und Deutschland eingesetzt. Die dargestellten Untersuchungsergebnisse im Zuge einer Bauwerksinspektion nach über zwei Jahrzehnten Nutzungsdauer liefern einen entscheidenden Baustein zur quantitativen Bewertung des Korrosionsschutzpotenzials epoxidharzbeschichteter Bewehrung. Die Resultate zeigen, dass sich die Epoxidharzbeschichtung auch nach mehr als 20 Jahren im Beton in einem guten, funktionsfähigen Zustand befindet. Zusätzlich wird anhand von Laborversuchen der mögliche Effekt eines erhöhten kritischen Chloridgehalts bei ECR‐Einsatz (an Fehlstellen < 50 mm2) erstmals nachgewiesen. Eine hierdurch resultierende Lebensdauerverlängerung wird über eine erste Lebensdauerberechnung abgeschätzt.

Epoxy‐coated reinforcement – New findings after two decades of practical experience

Epoxy‐coated reinforcement (ECR) as a measure against chloride‐induced corrosion of steel in concrete has until now particularly in North America been used in considerable amounts. Nevertheless, in literature the mechanism of action and the potential corrosion protection effect of ECR are controversially discussed. The lack of information concerning the long‐term behavior of ECR in concrete is one of the main reasons for the low level of application of ECR in Germany or Europe in general. In 1989 and 1991, two road bridges were constructed with ECR as pilot projects in both Switzerland and Germany. This paper presents results from condition assessments of the two bridges after more than two decades of service life. The results show that the epoxy coating is still in a good and functional condition after more than 20 years in concrete. In addition, possible higher critical chloride contents at small defects of ECR (< 50 mm2) have been verified in laboratory tests for the first time. The possible resulting service life prolongation is assessed by first service life calculations.
Entwicklung der Spannbetonvorschriften in der DDR
Authors: Mertzsch Olaf
Published: January 2014

Die Spannbetonbemessung in der DDR wurde zunächst durch die DIN 4227 bestimmt. Im Jahr 1964 erfolgte die Einführung der TGL 0‐4227. Diese Norm erlaubte auch die Spannbetonbemessung im Zustand II. In den 1970er‐Jahren wurde mit dem “Einheitliches technisches Vorschriftenwerk Beton” (ETV Beton) ein Bemessungsverfahren auf der Grundlage des semiprobabilistischen Sicherheitskonzepts entwickelt und 1981 verbindlich eingeführt. Die seinerzeitigen Berechnungsansätze entsprechen weitgehend den Annahmen des heutigen Eurocodes.

Development of prestressed concrete rules in the GDR – 50 years TGL 0‐4227

The pre‐stressed concrete calculation in the GDR was defined by the DIN 4227 for the first time. In 1964 the TGL 0 4227 was introduced. This standard also allowed for the dimensioning of prestressed concrete in state II In the seventies, the uniform technical rules and regulations concrete (ETV Beton) was developed as a design method based on the semi‐probabilistic safety concept, and introduced in 1981 obligatory. These former calculation approaches are similar to the assumptions of today's eurocodes.
Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space‐time yields for less complex proteins
Authors: Maccani Andreas , Landes Nils , Stadlmayr Gerhard , Maresch Daniel , Leitner Christian , Maurer Michael , Gasser Brigitte , Ernst Wolfgang , Kunert Renate , Mattanovich Diethard
Published: January 2014

Chinese hamster ovary (CHO) cells are currently the workhorse of the biopharmaceutical industry. However, yeasts such as Pichia pastoris are about to enter this field. To compare their capability for recombinant protein secretion, P. pastoris strains and CHO cell lines producing human serum albumin (HSA) and the 3D6 single chain Fv‐Fc anti‐HIV‐1 antibody (3D6scFv‐Fc) were cultivated in comparable fed batch processes. In P. pastoris, the mean biomass‐specific secretion rate (qp) was 40‐fold lower for 3D6scFv‐Fc compared to HSA. On the contrary, qp was similar for both proteins in CHO cells. When comparing both organisms, the mean qp of the CHO cell lines was 1011‐fold higher for 3D6scFv‐Fc and 26‐fold higher for HSA. Due to the low qp of the 3D6scFv‐Fc producing strain, the space‐time yield (STY) was 9.6‐fold lower for P. pastoris. In contrast, the STY of the HSA producer was 9.2‐fold higher compared to CHO cells because of the shorter process time and higher biomass density. The results indicate that the protein secretion machinery of P. pastoris is much less efficient and the secretion rate strongly depends on the complexity of the recombinant protein. However, process efficiency of the yeast system allows higher STYs for less complex proteins.
Hydrogen‐Bonding in Aminocatalysis: From Proline and Beyond
Authors: Albrecht Łukasz , Jiang Hao , Jørgensen Karl Anker
Published: January 2014

Invited for the cover of this issue is the group of Karl Anker Jørgensen at the University of Aarhus. The image depicts the concept of the central role that hydrogen plays in hydrogen‐bonding aminocatalysis. Read the full text of the article at 10.1002/chem.201303982.
ChemInform Abstract: Structure and Reactivity of Binary Au12Pt Cluster.
Authors: Kuang Xiangjun , Wang Xinqiang , Liu Gaobin
Published: January 2014

An all‐electron scalar relativistic calculation on the geometrical structure and reactivity of Au12Pt cluster is performed by DFT with the generalized gradient approximation at PW91 level.
ChemInform Abstract: Li10SnP2S12: An Affordable Lithium Superionic Conductor.
Authors: Bron Philipp , Johansson Sebastian , Zick Klaus , Schmedt auf der Guenne Joern , Dehnen Stefanie , Roling Bernhard
Published: January 2014

The title compound is prepared from a stoichiometric mixture of Li4SnS4, Li2S, and P2S5 (evacuated quartz tube, 600 °C, 48 h).
ChemInform Abstract: Phase Chemistry in the Ca—Mn—Sb—O System at 1160—1250 °C.
Authors: Bazuev Gennady V. , Tyutyunnik Aleksander P. , Golovkin Boris G.
Published: January 2014

The new compound Ca7Sb2O12 is identified in the title system.
ChemInform Abstract: Three‐Dimensional MoS2 Hierarchical Nanoarchitectures Anchored into a Carbon Layer as Graphene Analogues with Improved Lithium Ion Storage Performance.
Authors: Zhao Xinyu , Hu Changwen , Cao Minhua
Published: January 2014

Graphene‐like MoS2 nanosheets uniformly dispersed in an amorphous carbon matrix are hydrothermally synthesized from mixtures of (NH4)6Mo7O24, thiourea, polyvinylpyrrolidone, and water (autoclave, 180 °C, 24 h).
ChemInform Abstract: Core/Shell Photocatalyst with Spatially Separated Co‐Catalysts for Efficient Reduction and Oxidation of Water.
Authors: Wang Daoai , Hisatomi Takashi , Takata Tsuyoshi , Pan Chengsi , Katayama Masao , Kubota Jun , Domen Kazunari
Published: January 2014

SiO2/Ta3N5 core/shell photocatalysts loaded with Pt nanoparticles on the inner Ta3N5 shell surface and IrO2 or CoOx on the outer shell surface show significantly enhanced water reduction and oxidation performance under visible light irradiation.
ChemInform Abstract: From an Open Framework to a Layered and a Hexagonal Tungsten Oxide Structure: Controlled Transformation Reactions of an Extended Solid‐State Material, Cs3Ga7(SeO3)12 to Ga(OH)(SeO3) and KGa3(SeO4)2(OH)6.
Authors: Ahn Hyun Sun , Lee Dong Woo , Ok Kang Min
Published: January 2014

Crystal structures of compounds (IV), (VII), and (X) are determined by single crystal XRD.
ChemInform Abstract: Synthesis and Modular Structural Architectures of Mineralogically Inspired Novel Complex Pb Oxyhalides.
Authors: Siidra Oleg I. , Zinyakhina Diana O. , Zadoya Anastasiya I. , Krivovichev Sergey V. , Turner Rick W.
Published: January 2014

The crystal structures of compounds (IV), (VII), and (IX) are determined by single crystal XRD.
ChemInform Abstract: Selective Aerobic Oxidation of Methanol in the Coexistence of Amines by Nanoporous Gold Catalysts: Highly Efficient Synthesis of Formamides.
Authors: Tanaka Shinya , Minato Taketoshi , Ito Eisuke , Hara Masahiko , Kim Yousoo , Yamamoto Yoshinori , Asao Naoki
Published: January 2014

A highly efficient access to formamides by gold‐catalyzed aerobe oxidative reaction of methanol and various primary and secondary amines with good to excellent yields is presented.
ChemInform Abstract: Rasta Resin‐TBD as a Reusable Catalyst for Transesterification Reactions.
Authors: Yang Yun‐Chin , Leung Dennis Y. C. , Toy Patrick H.
Published: January 2014

A rasta resin‐supported TBD polymer is prepared and successfully used as reusable catalyst for the alcoholysis of vinyl acetate.
ChemInform Abstract: Olefin‐Assisted Iron‐Catalyzed Alkylation of Aryl Chlorides.
Authors: Guelak Samet , Gieshoff Tim N. , Jacobi van Wangelin Axel
Published: January 2014

The reaction tolerates a wide range of functional groups and exhibits high chemoselectivity.
ChemInform Abstract: A Twin‐axial[5]pseudorotaxane Based on Cucurbit[8]uril and α‐Cyclodextrin.
Authors: Wang Li‐Hua , Zhang Zhi‐Jun , Zhang Heng‐Yi , Wu Hai‐Lang , Liu Yu
Published: January 2014

The title compound consists of a 1‐hexyl‐4,4′‐bipyridinium guest and cucurbit[8]uril (CB[8]) and α‐cyclodextrin.
ChemInform Abstract: Novel Organomagnesium Reagents in Synthesis. Catalytic Cyclomagnesiation of Allenes in the Synthesis of N‐, O‐, and Si‐Substituted 1Z,5Z‐Dienes.
Authors: D'yakonov Vladimir A. , Makarov Aleksey A. , Makarova Elina Kh. , Dzhemilev Usein M.
Published: January 2014

Allenes (I) undergo intermolecular cross‐cyclomagnesiation to yield dienic dimers of type (II) after hydrolytic workup.
ChemInform Abstract: “One‐Pot” Reductive Lactone Alkylation Provides a Concise Asymmetric Synthesis of Chiral Isoprenoid Targets.
Authors: Cao Jia , Perlmutter Patrick
Published: January 2014

Nucleophilic addition‐ring opening of lactones followed by modified in situ Clemmensen reduction provides a short synthetic route to chiral isoprenoid targets (III).
ChemInform Abstract: Microwave Assisted Efficient Aminocarbonylation of N‐Tosylhydrazones with Molybdenum Hexacarbonyl and Amines.
Authors: Rao K. Penta , Basak Ashok K. , Raju Amancha , Patil Vikas S. , Reddy L. Krishnakanth
Published: January 2014

An efficient aminocarbonylation of N‐tosylhydrazones in the presence of molybdenum hexacarbonyl is reported.
ChemInform Abstract: Development of an Improved Rhodium Catalyst for Z‐Selective anti‐Markovnikov Addition of Carboxylic Acids to Terminal Alkynes.
Authors: Wei Siping , Pedroni Julia , Meissner Antje , Lumbroso Alexandre , Drexler Hans‐Joachim , Heller Detlef , Breit Bernhard
Published: January 2014

The regioselective Rh‐catalyzed addition reaction of carboxylic acids to terminal alkynes in the presence of 2‐diphenylphosphinomethylpyridine as the catalytic ligand is studied.
ChemInform Abstract: Enantioselective Organocatalytic Fluorination‐Induced Wagner—Meerwein Rearrangement.
Authors: Romanov‐Michailidis Fedor , Guenee Laure , Alexakis Alexandre
Published: January 2014

This novel highly enantioselective title reaction affords a wide range of fluorinated spirocyclic derivatives by using the new BINOL derived phosphoric acid (BIN).
ChemInform Abstract: Heterogeneous Photocatalyzed Heck Reaction over PdCl2/TiO2.
Authors: Waghmode Suresh B. , Arbuj Sudhir S. , Wani Bina N.
Published: January 2014

The catalyst can be generated and reused up to three times with good catalytic activity.
ChemInform Abstract: Exploring the Potential of Diarylacetylenediols as Hydrogen Bonding Catalysts.
Authors: Tuerkmen Yunus E. , Rawal Viresh H.
Published: January 2014

Title compounds possessing an electron‐withdrawing group show increased activity as catalysts in Diels—Alder reactions but they also undergo facile, spontaneous cyclization into benz[b]furans.
ChemInform Abstract: Hydrogenation of Nitroarenes Using Defined Iron—Phosphine Catalysts.
Authors: Wienhoefer Gerrit , Baseda‐Krueger Mario , Ziebart Carolin , Westerhaus Felix A. , Baumann Wolfgang , Jackstell Ralf , Junge Kathrin , Beller Matthias
Published: January 2014

A novel, highly chemoselective hydrogenation of nitroarenes to corresponding amines (18 examples) is developed.
ChemInform Abstract: A Practical and Convenient Protocol for the Synthesis of (E)‐α,β‐Unsaturated Acids.
Authors: Mohite Amar R. , Bhat Ramakrishna G.
Published: January 2014

Decarboxylation of cyclic 1,3‐diesters, generated from Meldrum′s acid and aldehydes or ketones, provide α,β‐unsaturated acids with high E‐selectivity.
ChemInform Abstract: Allylic C—H Alkylation with a CF3‐Containing Nucleophile.
Authors: Li Lun , Chen Qing‐Yun , Guo Yong
Published: January 2014

Compounds (III) and (V) containing an all‐carbon quaternary center are synthesized by allylic C—H alkylation of allylarenes (I) with esters (II) and (IV).
ChemInform Abstract: Palladium‐Catalyzed Aminocarbonylation of Aryl Iodides Using Aqueous Ammonia.
Authors: Xu Tongyu , Alper Howard
Published: January 2014

Aminocarbonylation of aromatic iodides using aqueous ammonia in toluene is processed using Pd(OAc)2/CYTOP®292 (TPA) as catalyst.
ChemInform Abstract: Chirality of the Molecular Assembly Determined by Intra‐/Inter‐N—H···O Hydrogen Bonding in Doubly Substituted N‐Octanoylglyoxylic Amides.
Authors: Suryanti Venty , Bhadbhade Mohan , Bishop Roger , Black David StC. , Kumar Naresh
Published: January 2014

N‐Octanoylisatins undergo nucleophilic ring opening upon treatment with amines to afford the title amides (IV) and (VI).
ChemInform Abstract: Copper‐Mediated Cyanation of Aryl Boronic Acids Using Benzyl Cyanide.
Authors: Luo Yan , Wen Qiaodong , Wu Zhiyuan , Jin Jisong , Lu Ping , Wang Yanguang
Published: January 2014

Various arylboronic acids are converted into aryl nitriles using benzyl cyanides which act as cyanide source upon treatment with CuI/tBuOOH.
ChemInform Abstract: Synthesis of a Thermostable Polymer‐Supported Strongly Basic Catalyst and its Catalytic Activity.
Authors: Zan Huining , Hou Zhiai , Shi Rongfu , Wang Chunhong
Published: January 2014

A novel strongly basic polymer‐supported catalyst with guanidine groups is synthesized and successfully applied in Knoevenagel condensation reactions.
ChemInform Abstract: Synthesis, Structural Characterization and Catalytic Activity of Benzimidazole‐Functionalized Pd(II) N‐Heterocyclic Carbene Complexes.
Authors: Diao Yalin , Hao Rong , Kou Junfeng , Teng Mingyu , Huang Guoli , Chen Yegao
Published: January 2014

The title complexes are efficient catalysts for Mizoroki‐Heck reactions under mild conditions.
ChemInform Abstract: Regio‐ and Stereoselective Synthesis of (Z)‐2‐Arylsulfanyl Allylic Alcohols Using Anhydrous CeCl3 as Catalyst under Solvent Free Conditions.
Authors: Silveira Claudio C. , Martins Guilherme M. , Mendes Samuel R.
Published: January 2014

The title reaction is studied.
ChemInform Abstract: Controllable Mono‐/Dialkenylation of Benzyl Thioethers Through Rh‐Catalyzed Aryl C—H Activation.
Authors: Zhang Xi‐Sha , Zhu Qi‐Lei , Zhang Yun‐Fei , Li Yan‐Bang , Shi Zhang‐Jie
Published: January 2014

A thioether‐directed Rh‐catalyzed oxidative alkenylation of arenes is described.
ChemInform Abstract: Template‐Less Synthesis of Polymer Hollow Spheres: An Efficient Catalyst for Suzuki Coupling Reaction.
Authors: Choudhary Meenakshi , Islam Rafique Ul , Witcomb Michael J. , Phali Motlatsi , Mallick Kaushik
Published: January 2014

This method uses low catalyst loadings and has TOFs up to 2340 h‐1.
ChemInform Abstract: Oxyarylation and Aminoarylation of Styrenes Using Photoredox Catalysis.
Authors: Fumagalli Gabriele , Boyd Scott , Greaney Michael F.
Published: January 2014

The newly developed three‐component coupling of styrenes proceeds well with a low catalyst loading.
ChemInform Abstract: Gold(I)‐Catalyzed Functionalization of Benzhydryl C(sp3)—H Bonds.
Authors: Cera Gianpiero , Chiarucci Michel , Dosi Federico , Bandini Marco
Published: January 2014

A 1,5‐hydride shift is believed to be the key step of the cascade reaction.
ChemInform Abstract: Development of an Expedient Intramolecular Pauson—Khand Reaction Approach to Stereoselectively Construct the trans‐Decalin (XII) with a C1 Quaternary Chiral Center.
Authors: Shi Li‐Li , Shen Hong‐Juan , Fang Li‐Chao , Huang Jun , Li Chuang‐Chuang , Yang Zhen
Published: January 2014

Title reaction to synthesize trans‐decalins [(III), (V), (VII), (IX) and (XI)] is accomplished by using Co2(CO)8 and trimethylamine N‐oxide as promoter.
ChemInform Abstract: A Novel Reaction of the “Huisgen Zwitterion” with Benzofuran‐2,3‐diones: An Efficient Strategy for the Synthesis of Spirocyclic Benzofuran‐2‐one Derivatives.
Authors: Wang Ze‐Dong , Dong Nan , Wang Feng , Li Xin , Cheng Jin‐Pei
Published: January 2014

The nitrogen‐based nucleophile generated from azodicarboxylate and triphenylphosphine displays good reactivity toward benzofuran‐2,3‐diones to generate a variety of spirocyclic benzofuran‐2‐one derivatives.
ChemInform Abstract: Modular Synthesis of All‐Substituted Furans Through Oxidative Carbonylation of Cyclopropenes with Tandem Metal Relay Catalysis.
Authors: Song Chuanling , Dong Shuli , Feng Lei , Peng Xianlong , Wang Mingchao , Wang Jianwu , Xu Zhenghu
Published: January 2014

The title reaction allows the introduction of four different substituents into the furan core.
ChemInform Abstract: Synthesis, Structural Characterization, and Preliminary Evaluation of Non‐Indolin‐2‐one‐based Angiogenesis Inhibitors Related to Sunitinib (Sutent®).
Authors: Kelso Michael J. , et al. et al.
Published: January 2014

The indolin‐2‐one fused ring system and the 2,4‐dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib.
ChemInform Abstract: Diversity‐Oriented Three‐Component Reactions of Diazo Compounds with Anilines and 4‐Oxo‐Enoates.
Authors: Jing Changcheng , Xing Dong , Qian Yu , Shi Taoda , Zhao Yun , Hu Wenhao
Published: January 2014

This new multicomponent reaction allows the selective synthesis of pyrrolidines or the corresponding linear α‐amino ester derivatives by controlling the addition sequence of the substrates.
ChemInform Abstract: A Catalyst‐ and Solvent‐Free Three‐Component Reaction for the Regioselective One‐Pot Access to Polyfunctionalized Pyrroles.
Authors: Bhat Subrahmanya Ishwar , Trivedi Darshak R.
Published: January 2014

An improved and greener protocol for the reaction of 1,3‐dicarbonyl compounds, benzoin derivatives and ammonium acetate to give tetrasubstituted pyrroles is developed.
ChemInform Abstract: Cu‐Mediated 1,3‐Dipolar Cycloaddition of Azomethine Ylides with Dipolarophiles: A Faster Access to Spirooxindoles of Potential Pharmacological Interest.
Authors: Singh Shambhu Nath , Regati Sridhar , Paul Abir Kumar , Layek Mohosin , Jayaprakash Sarva , Reddy K. Venkateshwara , Deora Girdhar Singh , Mukherjee Soumita , Pal Manojit
Published: January 2014

The first Cu‐mediated one‐pot three‐component reaction of isatin derivatives (I), L‐proline (II), and terminal alkynes (III) leading to spiropyrrolidine oxindols (IV) is reported.
ChemInform Abstract: Rh(III)‐Catalyzed Tandem C—H Allylation and Oxidative Cyclization of Anilides: A New Entry to Indoles.
Authors: Cajaraville Ana , Lopez Susana , Varela Jesus A. , Saa Carlos
Published: January 2014

Optimized reaction conditions allow the synthesis of 2‐methylindoles via oxidative cyclization of various acetanilides (I) with allyl carbonate (II).
ChemInform Abstract: Regiocontrolled Synthesis of 3‐ and 5‐Aminopyrazoles, Pyrazolo[3,4‐d]pyrimidines, Pyrazolo[3,4‐b]pyridines and Pyrazolo[3,4‐b]quinolinones as MAPK Inhibitors.
Authors: Bagley Mark C. , Baashen Mohammed , Paddock Victoria L. , Kipling David , Davis Terence
Published: January 2014

This presents methods for the regioselective synthesis of 3‐ and 5‐aminopyrazoles and their transformation to polycyclic MAPK inhibitors, e.
ChemInform Abstract: DBSA Mediated Chemoselective Synthesis of 2‐Substituted Benzimidazoles in Aqueous Media.
Authors: Kumar Vikash , Khandare Dipratn G. , Chatterjee Amrita , Banerjee Mainak
Published: January 2014

An efficient method for the synthesis of 2‐substituted benzimidazoles in organized aqueous media in the presence of a surfactant like dodecylbenzenesulfonic acid as catalyst and iodine as co‐catalyst is developed.
ChemInform Abstract: Reaction of Carbon Disulfide with 2‐Bromoimidazolium Salts. Novel Bicyclic Mesoionic Thiazolo[3,2‐a]imidazoles.
Authors: Zama Sana , Bouraiou Abdelmalek , Bouacida Sofiane , Roisnel Thierry , Belfaitah Ali
Published: January 2014

A simple protocol is presented for the cyclocondensation of imidazolium salts with carbon disulfide to produce a new class of mesoionic thiazoloimidazoles.
ChemInform Abstract: Asymmetric Synthesis of (—)‐Bissetone via a Highly Enantioselective Hetero‐Diels—Alder Reaction.
Authors: Majer Jakub , Jurczak Janusz , Kwiatkowski Piotr , Cotarca Livius
Published: January 2014

A highly enantioselective hetero‐Diels—Alder reaction of triene (I) and ethyl glyoxylate by using a readily available Ti‐BINOL complex as catalyst is developed.
ChemInform Abstract: Novel Nitenpyram Analogues with Tetrahydropyridone‐Fixed cis‐Configuration: Synthesis, Insecticidal Activities, and Molecular Docking Studies.
Authors: Sun Chuan‐Wen , Wang Jing , Wu Ying , Nan Shi‐Bin , Zhang Wang‐Geng
Published: January 2014

Title compounds (IV) are synthesized via three‐component microwave assisted reaction of nitenpyram (I), aromatic aldehydes (II) and Meldrum′ acid (III).
ChemInform Abstract: An Enantioselective Artificial Metallo‐Hydratase.
Authors: Bos Jeffrey , Garcia‐Herraiz Ana , Roelfes Gerard
Published: January 2014

The first artificial metallo‐hydratase, which catalyses the conjugate addition of water to give chiral β‐hydroxy ketones with high enantioselectivities is described.
ChemInform Abstract: Nickel‐Catalyzed Enantioselective Arylation of Pyridinium Ions: Harnessing an Iminium Ion Activation Mode.
Authors: Chau Stephen T. , Lutz J. Patrick , Wu Kevin , Doyle Abigail G.
Published: January 2014

This novel enantioselective Negishi cross‐coupling reaction affords a wide range of synthetically valuable pyridone derivatives from readily prepared starting materials.
ChemInform Abstract: Synthesis of Epoxyisoindolo[1,2‐a]isoquinolinium Salts by an Intramolecular [2 + 4] Cycloadditon Reaction in 2‐Allyl‐1‐furylisoquinolinium Halides.
Authors: Zaytsev V. P. , et al. et al.
Published: January 2014

A fundamentally novel method for the synthesis of analogues of the isoindolo[1,2‐a]isoquinoline alkaloids jamtine and hirsutine is developed using the tandem alkylation/[2 + 4] cycloaddition of 1‐(2‐furyl)‐3,4‐dihydroisoquinolines (II) by various allyl halides.
ChemInform Abstract: Synthesis of Azahelicene N‐Oxide by Palladium‐Catalyzed Direct C—H Annulation of a Pendant (Z)‐Bromovinyl Side Chain.
Authors: Kaneko Eri , Matsumoto Yuki , Kamikawa Ken
Published: January 2014

The products can be further substituted in a slightly modified protocol using aryl bromides as substrates [products (IV)].
ChemInform Abstract: Modular Strategy for the Synthesis of Functionalized Aryl‐Fused Azabicyclo[2.2.2]octanes via Sequential Cu/Pd/Ru Catalysis.
Authors: McCormick Lucas F. , Malinakova Helena C.
Published: January 2014

This reaction sequence is suitable for substituted benzimines (I) to give products (IV), (V), and (VI), while an imine derived from 3‐bromo‐thiophen‐2‐yl carbaldehyde does not yield a corresponding Heck product.
ChemInform Abstract: An Alternative Synthetic Approach for the Synthesis of Biologically Relevant 1,4‐Disubstituted Pyrazolo[3,4‐d]pyrimidines.
Authors: Radi Marco , Bernardo Vincenzo , Vignaroli Giulia , Brai Annalaura , Biava Mariangela , Schenone Silvia , Botta Maurizio
Published: January 2014

An alternative approach for the synthesis of the title compounds is developed based on TBAF‐mediated N‐1‐functionalization of readily available chlorinated allopurinol (I) followed by C‐4 nucleophilic substitution under different conditions.
ChemInform Abstract: Copper‐Catalyzed Intramolecular Electrophilic Carbofunctionalization of Allylic Amides.
Authors: Cahard Elise , Bremeyer Nadine , Gaunt Matthew J.
Published: January 2014

This intramolecular, endo‐selective oxyarylation and oxyvinylation of allylic amides affords highly functionalized oxazine derivatives.
ChemInform Abstract: Design and Synthesis of 4‐Alkyl‐2‐amino(acetamino)‐6‐aryl‐1,3‐thiazine Derivatives as Influenza Neuraminidase Inhibitors.
Authors: Li Wan , Xia Lin , Hu Aixi , Liu Ailin , Peng Junmei , Tan Weiqing
Published: January 2014

Most of the title compounds (V), (VII) exhibit potent NA inhibitory activity.
ChemInform Abstract: Cyclization versus 1,1‐Carboboration: Reactions of B(C6F5)3 with Propargyl Amides.
Authors: Melen Rebecca L. , Hansmann Max M. , Lough Alan J. , Hashmi A. Stephen , Stephan Douglas W.
Published: January 2014

It is demonstrated that B(C6F5)3 induces the intramolecular cyclization of propargyl amides to give 5‐alkylidene‐4,5‐dihydrooxazolium borate species with high Z‐selectivity.
ChemInform Abstract: Tunable BODIPY Derivatives Amenable to ′Click′ and Peptide Chemistry.
Authors: Hansen Anna Mette , Sewell Alan L. , Pedersen Rasmus H. , Long De‐Liang , Gadegaard Nikolaj , Marquez Rodolfo
Published: January 2014

The BODIPY‐functionalized azide (V) can be successfully used in Cu‐catalyzed 1,3‐dipolar cycloadditions with terminal alkynes which gives an easy access to different substituted BODIPY derivatives.