bluuebunny/crossref_metadata_2025 huggingface dataset:
Liraglutide protects against high-fat diet-induced kidney injury by ameliorating apoptosis
Authors: Liang Riying , Wang Meijun , Fu Chang , Liang Hua , Deng Hongrong , Tan Ying , Xu Fen , Cai Mengyin
Published: September 2020

Background:

Obesity is associated with the development and progression of chronic kidney disease. Emerging evidence suggests that glucagon-like peptide-1 receptor agonist could reduce renal damage and albuminuria. Sirtuin 1 (SIRT1) was considered as a crucial regulator in metabolism-related kidney disease. Herein, the role of SIRT1 in liraglutide-ameliorated high-fat diet (HFD)-induced kidney injury was illustrated.

Methods:

Male C57BL/6 mice were fed HFD for 20 weeks to induce kidney injury that was then treated with liraglutide for 8 weeks to estimate its protective effect on the kidney. Also, the mechanism of the drug in SV40 MES 13 (SV40) mouse mesangial cells was elucidated.

Results:

Liraglutide treatment ameliorated HFD-induced metabolic disorders, including hyperglycemia, increasing body weight, and insulin resistance. In addition, kidney weight, urine albumin-to-creatinine, and kidney morphological changes such as vacuolated tubules, glomerulomegaly, thickened glomerular basement membrane, and tubulointerstitial fibrosis were also significantly ameliorated. Furthermore, apoptotic cells and apoptosis markers were downregulated in the kidney of liraglutide-treated mice. In addition, the expression of SIRT1 protein was upregulated, whereas thioredoxin-interacting protein (TXNIP), which serves as a mediator of oxidative stress and apoptosis in metabolism disease, was downregulated by liraglutide. In SV40 cells, the effect of liraglutide on reversing the upregulation of cleaved caspase-3 induced by high glucose (30 mM) was hampered when SIRT1 was knocked down; also, the downregulation of TXNIP by liraglutide was blocked.

Conclusions:

Liraglutide might have a beneficial effect on metabolism-related kidney damage by inhibiting apoptosis via activation of SIRT1 and suppression of TXNIP pathway.
Dsg2-mediated c-Met activation in anaplastic thyroid cancer motility and invasion
Authors: Lee Kyungmin , Lee Sang-Hyun , Kim Wooil , Lee Jangwook , Park Jong-Gil , Kim Jang-Seong , Kim Jung Tae , Kang Yea Eun , Shong Minho , Lee Hyo Jin , Kim Jin-Man , Kim Won Gu , Koo Bon Seok , Kim Koon Soon , Min Jeong-Ki
Published: September 2020

Anaplastic thyroid cancer (ATC) is a rapidly growing, highly metastatic cancer with limited therapeutic alternatives, thus targeted therapies need to be developed. This study aimed to examine desmoglein 2 (Dsg2) expression in ATC and its biological role and potential as a therapeutic target in ATC. Consequently, Dsg2 was downregulated or aberrantly expressed in ATC tissues. ATC patients with low Dsg2 expression levels also presented with distant metastasis. Dsg2 depletion significantly increased cell migration and invasion, with a relatively limited effect on ATC cell proliferation in vitro and increased distant metastasis in vivo. Dsg2 knockdown induced cell motility through the hepatocyte growth factor receptor (HGFR, c-Met)/Src/Rac1 signaling axis, with no alterations in the expression of EMT-related molecules. Further, specific targeting of c-Met significantly inhibited the motility of shDsg2-depleted ATC cells. Decreased membrane Dsg2 expression increased the metastatic potential of ATC cells. These results indicate that Dsg2 plays an important role in ATC cell migration and invasiveness. Therapies targeting c-Met might be effective among ATC patients with low membrane Dsg2 expression levels, indicating that the analysis of Dsg2 expression potentially provides novel insights into treatment strategies for ATC.
Growing human trophoblasts in vitro: a review of the media commonly used in trophoblast cell culture
Authors: Nursalim Yohanes N S , Blenkiron Cherie , Groom Katie M , Chamley Lawrence W
Published: September 2020

Trophoblasts are unique epithelial cells found only in the placenta. It has been possible to isolate and maintain human trophoblasts in in vitro culture for many decades. During this period there have been a vast array of media and supplements reported for trophoblast culture and often the reasons for using the media and specific supplements employed in any given laboratory have been lost in the ‘mists of time’. After a gradual development over many years this field has recently changed, with the publication of several reports of the isolation, growth and differentiation of human trophoblast stem or stem-like cells. This advance was made largely because of a greater understanding of the molecular pathways that control human trophoblasts and availability of media supplements that can be used to manipulate those pathways. We have searched the literature and here summarise many of the different media and supplements and describe how and why they were developed and are used to culture human trophoblasts.
Obesity induction in adult zebrafish leads to negative reproduction and offspring effects
Authors: Virote Bárbara do Carmo Rodrigues , Moreira Amanda Maria Siqueira , Silva Souza José Gilmar da , Castro Tássia Flávia Dias , Melo Naiara , Carneiro William Franco , Drummond Cristina Delarete , Vianna André Rodrigues da Cunha Barreto , Murgas Luis David Solis
Published: September 2020

Obesity is a transgenerational epigenetic metabolic disturbance. Although the diet-induced obese (DIO) zebrafish model is well established, reproductive parameters and changes in offspring have not yet been evaluated. Thus, the aim of this study was to evaluate possible changes in reproductive parameters, embryos and offspring (F1) generated by the reproduction of diet-induced obese males and females. The adult zebrafish were divided into two groups: one group receiving a balanced diet (control group) and the other group was overfed (DIO group) . The dietary protocol was maintained for 8 weeks. During this period, males and females in the same group were stimulated through a weekly reproduction protocol. To verify parental obesity, body weight, blood glucose, triglyceride, the hepatosomatic and gonadosomatic index and adipose tissue morphometry evaluations were carried out. Reproductive parameters were evaluated through ovarian and oocyte maturation stage, total spawning, fertility and fertilization index. To verify possible changes caused by parenteral obesity, all offspring were kept in separate groups in correspondence with their parents and were fed a control diet. Plasma glucose, triglycerides, mortality rate, hatching, and deformities were determined. After 8 weeks under the diet protocol, the DIO group exhibited characteristic obesity alterations, displaying significant increases in body mass and hepatosomatic and gonadosomatic indices, hyperglycemia and visceral and subcutaneous adipocyte hypertrophy. In addition, high mortality rates, morphologic deformities and high plasmatic glucose and triglyceride levels, with 100% mortality at 60 dpf, were observed for the offspring. Therefore, obesity induction in adults led to negative effects on their offspring, with a high occurrence of deformities and mortality.
Aquapheresis: An Institutional Experience
Authors: Khine San Kyaw , Lam Eric , Dholakia Kush , Scheinerman S. Jacob , DeVita Maria
Published: September 2020

Background: Aquapheresis (AQ) consists of the extracorporeal extraction of plasma water from the vascular space across a semipermeable membrane in response to a transmembrane pressure gradient. The primary utilization of AQ has been in the management of patients with diuretic resistant heart failure with a treatment goal directed to quickly eliminate the excess fluid and optimize volume status. This modality is similar to isolated ultrafiltration performed on those patients requiring dialysis, but utilizes a machine that is smaller and easier to initiate and operate compared with traditional dialysis equipment.
Method: A retrospective study that describes the indications in which AQ was utilized at Lenox Hill Hospital. The patient list was generated by searching for the keyword “Aquaph” in our electronic health record (EHR) orders. Patients were categorized based on hospital location and indication of AQ therapy. Additional information includes duration of treatment (days), changes in creatinine (start of AQ to stop of AQ), and total volume removed.
Results: The search generated 28 patients; five were excluded as AQ was not initiated. In the remaining 23 patients, the mean aquapheretic volume per day was 1954 mls, with no significant change in creatinine. Indications for AQ broke out into five main categories: cardiogenic shock including post cardiothoracic procedure (10 pts); anasarca (5 pts); ATN with volume overload (4 pts); ESKD with bridge ultrafiltration between hemodialysis treatments (2 pts); and post-op volume overload (2 pts).
Conclusion: We found that aquapheresis can be utilized in situations other than diuretic resistant heart failure. Also to consider, is the ease in which this less complicated aquapheresis equipment can be operated compared to the more complex hemodialysis equipment.
Elicitación de la distribución multinomial a partir de varios expertos
Authors: Montoya Espinosa Yurledy , Correa Morales Juan Carlos
Published: September 2020

El objetivo de este trabajo es implementar una metodologa de elicitacion mediante el metodo Delphi que permita estimar el vector de parametros de la distribucion multinomial a partir de la cuanticacion de opinion y creencias de multiples expertos, buscando as conseguir un resultado diferenciador y de mas valor que la suma de aportaciones individuales para obtener una unica distribucion que represente el conocimiento del conjunto de expertos.
cubm package in R to fit CUB models
Authors: Barajas Freddy Hernández , Usuga Manco Olga Cecilia , García Muñoz Sebastián
Published: September 2020

The class of CUB models is commonly used by practitioners to model ordinal data, in this paper we propose the cubm package which provides the class of CUB models in the R system for statistical computing. The cubm package allows to specify a formula for each parameter of the model, the Maximum Likelihood (ML) estimation is performed by optimization via the functions nlminb, optim and DEoptim and the variance-covariance matrix can be obtained by numerical approximation of the Hessian matrix or by bootstrap method. The utility of the package is illustrated by an application and a simulation study.
Reflexión sobre la exhortación apostólica Evangelii Gaudium
Authors: Martínez Mora Felipe Augusto
Published: September 2020

La propuesta del papa Francisco para la renovación de la Iglesia es la misión. Tomamos como punto de partida la invitación del papa Francisco a salir al encuentro con el otro para proponer la reflexión sobre la incidencia que tiene en él la cuestión teológica. Es necesario, urgente, que la misión modifique la acción pastoral y el lenguaje teológico, ya que el decir y el hacer están estrechamente unidos. Dios, Jesucristo, el hombre, la cultura y las consecuencias éticas de la transformación misionera son los temas que se pretenden abordar en este artículo. El papa Francisco afirma que la misión es transformadora y que hay que dejar todo de manera distinta a como estaba, la teología tiene que dejarse interpelar por la praxisde la evangelización y a su vez la evangelización tiene que alimentarse de la  teología que manifiesta la grandeza de Dios y el hombre.
RPL-4 and RPL-9 ̶Mediated Ribosome Purifications Facilitate the Efficient Analysis of Gene Expression in Caenorhabditis elegans Germ Cells
Authors: Nousch Marco
Published: September 2020

In many organisms, tissue complexity and cellular diversity create a barrier that can hinder our understanding of gene expression programs. To address this problem, methods have been developed that allow for easy isolation of translated mRNAs from genetically defined cell populations. A prominent example is the Translating Ribosome Affinity Purification method also called TRAP. Here, ribosome associated mRNAs are isolated via purification of the ribosomal protein RPL10A/uL1, which is expressed under the control of a tissue specific promoter. Originally developed to investigate gene expression in mouse neurons, it has by now been adopted to many different organisms and tissues. Interestingly, TRAP has never been used successfully to analyze mRNA translation in germ cells. Employing a combination of genetic and biochemical approaches, I assessed several ribosomal proteins for their suitability for TRAP using the Caenorhabditis elegans germline as a target tissue. Surprisingly, I found that RPL10A/uL1 is not the ideal ribosomal component to perform such an analysis in germ cells. Instead other proteins such as RPL4/uL4 or RPL9/eL6 are much better suited for this task. Tagged variants of these proteins are well expressed in germ cells, integrated into translating ribosomes and do not influence germ cell functions. Furthermore, germ cell-specific mRNAs are much more efficiently co-purified with RPL4/uL4 and RPL9/uL6 compared to RPL10A/uL1. This study provides a solid basis upon which future germ cell TRAP experiments can be built, and it highlights the need for rigorous testing when adopting such methods to a new biological system.
HtsRC-Mediated Accumulation of F-Actin Regulates Ring Canal Size During Drosophila melanogaster Oogenesis
Authors: Gerdes Julianne A , Mannix Katelynn M , Hudson Andrew M , Cooley Lynn
Published: September 2020

Ring canals in the female germline of Drosophila melanogaster are supported by a robust filamentous actin (F-actin) cytoskeleton, setting them apart from ring canals in other species and tissues. Previous work has identified components required for the expansion of the ring canal actin cytoskeleton, but has not identified the proteins responsible for F-actin recruitment or accumulation. Using a combination of CRISPR-Cas9 mediated mutagenesis and UAS-Gal4 overexpression, we show that HtsRC—a component specific to female germline ring canals—is both necessary and sufficient to drive F-actin accumulation. Absence of HtsRC in the germline resulted in ring canals lacking inner rim F-actin, while overexpression of HtsRC led to larger ring canals. HtsRC functions in combination with Filamin to recruit F-actin to ectopic actin structures in somatic follicle cells. Finally, we present findings that indicate that HtsRC expression and robust female germline ring canal expansion are important for high fecundity in fruit flies but dispensable for their fertility—a result that is consistent with our understanding of HtsRC as a newly evolved gene specific to female germline ring canals.
PHYSIOCHEMICAL PROPERTIES AND ACE INHIBITORY CAPACITY OF HAZELNUT PROTEIN ISOLATE AND HYDROLYSATES
Authors: EROGLU EVREN CAGLAR , Oztop Kamuran , Aksay Salih
Published: September 2020

Protein solubility, water holding capacity, fat absorption capacity, emulsion activity index, emulsion stability index, gel formation capacity and Angiotensin-Converting Enzyme (ACE) inhibitory capacity of hazelnut protein isolate (HPI) and its hydrolysate were determined. The results showed that protein solubility had U shape solubility profile with an isoelectric point at pH 4.5-5 and highest value at pH 2 and pH 10.  Water holding capacity and fat absorption capacity of HPI was found as 1.95 mL water/g protein and 2.1 g fat/g protein, respectively. Emulsion activity index and emulsion stability index values were found as 44 m2/g and 46 min at pH 7.0, respectively. Weak gel formation of HPI was seen at 8% and firm gel (LGC) was observed at 12% protein concentration. The concentration of pepsin hydrolysates needed to inhibit 50% of the ACE activity values (IC50) at 0, 30, 60 and 120 min of hydrolysis were 1.47 mg protein/mL, 0.27 mg protein/mL, 0.27 mg protein/mL and 0.26 mg protein/mL respectively. Whereas, IC50 of trypsin hydrolysates at 0, 30, 60 and 120 min were 5.51 mg protein/mL, 0.61 mg protein/mL, 0.56 mg protein/mL and 0.54 mg protein/mL. These results showed that isolates and hydrolysates of hazelnut has valuable functional properties and noted as good candidates for effectively reducing hypertension.
Estratégias de aprendizagem na educação a distância: revalidação de uma escala
Authors: Umekawa Elienay Eiko Rodrigues , Zerbini Thaís
Published: September 2020

Frente a uma nova realidade educacional, o ensino a distância atesta suas contribuições aos processos formativos de modo que compreender o padrão de uso das estratégias de aprendizagem online torna-se fundamental para o aperfeiçoamento do planejamento educacional pois favorece o reconhecimento dos processos individuais de aprendizagem bem como dos procedimentos instrucionais adequados. Este artigo objetiva contribuir com o campo educacional ao verificar evidências de validade da ferramenta “Estratégias de Aprendizagem”. Participaram do estudo 126 alunos inscritos em cursos a distância ofertados por instituições de ensino do interior paulista. Após coleta de dados foram efetuadas análises estatísticas de Componentes Principais e Fatoriais, e de consistência interna (alfa de Cronbach). Após validação estatística a escala apresentou quatro fatores: Monitoramento da compreensão, 14 itens (α = 0,87); Estratégias autorregulatórias, 7 itens (α = 0,80); Busca de ajuda interpessoal, 3 itens (α = 0,82); Estratégias cognitivo-comportamentais, 7 itens (α = 0,78). Os resultados indicam que a escala é estatisticamente válida e confiável.
O viés da aquiescência e a estrutura fatorial do Dirty Dozen e do Short Dark Triad
Authors: Simões Natália Costa , Hauck Nelson
Published: September 2020

A tríade sombria—maquiavelismo, narcisismo e psicopatia—tem sido tradicionalmente avaliada via inventários de autorrelato. Entretanto, instrumentos de autorrelato podem estar suscetíveis à aquiescência ou tendência a concordar com itens mesmo quando possuem conteúdo antagônico. O presente estudo teve por objetivo investigar a dimensionalidade de dois populares instrumentos de autorrelato da tríade, o Dirty Dozen e o Short Dark Triad, verificando a interferência do viés da aquiescência na estrutura fatorial de cada medida. Participaram do estudo 449 universitários (média de idades = 23,47; DP = 6,76; 64% mulheres). O controle da aquiescência produziu soluções fatoriais mais interpretáveis do que a tradicional modelagem bi-factor, amplamente utilizada na área. Os achados também revelam fragilidades na composição teórica de ambos os instrumentos. Argumenta-se que a economia das medidas breves da “tríade sombria” não deve vir desencontrada de uma estrutura fatorial que reflita o conhecimento atual sobre a multidimensionalidade desses traços.
The Synthesis of Edible Film from Tilapia Fish (Oreochromis niloticus) Bones for Ecofriendly Material of Halal Packaging Applications
Authors: Windayani Neneng , Irwansyah Ferli Septi , Effendi Meila N
Published: September 2020

Packaging materials, especially in food is the most important of healthy aspect. However, today many types of packaging materials used are hazardous to health and environment, then was found alternative halal packaging materials that are safe for health and environment. One of the alternatives is edible film, synthesis from tilapia bone gelatin, it is using sorbitol as plasticizer. Edible film synthesized by dissolving tilapia fish (Oreochromis niloticus) from bone gelatin in distilled water containing sorbitol, then stirred, poured on flat glass, and heated at 50°C. The procedure is performed with a concentration of gelatin (8% and 10% w/v) and sorbitol (25% and 37% v/v). Then was characterized it is mechanical properties include thickness, tensile strength, and elongation to determine eligibility. The optimum condition of the edible film was obtained from 10% concentration of gelatin with 37% sorbitol, with the character of it is mechanical properties value are 0.05 mm thickness, 3,07 MPa tensile strength, and 64.34% elongation.
O PROGRAMA MAIS MÉDICOS E ALOCAÇÃO EQUITATIVA DE MÉDICOS NA ATENÇÃO PRIMÁRIA À SAÚDE (2013-2017)
Authors: Macedo Alex dos Santos , Ferreira Marco Aurélio Marques
Published: September 2020

RESUMO Analisou-se o processo alocativo de médicos pelo Programa Mais Médicos (PMM), procurando identificar se o objetivo de priorizar os municípios com maiores vulnerabilidades em saúde, a fim de reduzir a escassez de médicos no território nacional, foi cumprido. Para tanto, a partir de aspectos epidemiológicos e socioeconômicos foi construído o Índice de Vulnerabilidade e Condições em Saúde (IVCS) antes e após a implementação do PMM, nos períodos de 2012 e 2015, para mais de 97% de todos os 5.570 municípios brasileiros. Em seguida, analisou-se o processo alocativo de médicos considerando o índice proposto. Os resultados indicaram incremento de médicos no período em estudo (2013 a 2017) em territórios anteriormente desassistidos ou com dificuldades de fixação de médicos. Houve ampliação na cobertura e alocação de médicos em municípios em situação de severa e alta vulnerabilidade em saúde, nos municípios de pequeno porte e situados nas regiões norte e nordeste do país. Entretanto, evidenciou-se iniquidades alocativas e redução da oferta regular de médicos nos municípios em condição severa de vulnerabilidade e naqueles de pequeno porte.
PROPOSTA DE CONSTRUÇÃO DE MODELO DE MATURIDADE EM GOVERNANÇA E GESTÃO DE TIC
Authors: Santos Pedro Otávio Londe dos , Silva Ana Paula Bernardi da , Souza Neto João , Sousa Júnior Rafael Timóteo de
Published: September 2020

RESUMO Trata-se de uma proposta de um modelo de avaliação da maturidade em governança e gestão de Tecnologia da Informação e Comunicação (TIC) para os órgãos da Administração Pública Federal (APF) pertencentes ao Sistema de Administração dos Recursos de Informação e Informática (SISP) do Poder Executivo. Identificou-se os critérios de maturidade da literatura que subsidiaram a aplicação da Teoria Fundamentada para se obter as conceituações sobre governança e gestão de TIC na visão do SISP. De posse desses elementos, elaborou-se o referido modelo para fomentar a melhoria dos níveis de maturidade em governança e gestão de TIC no Governo Federal sob a ótica do SISP. A pesquisa concluiu que a maturidade em governança e gestão de TIC envolve mudanças no desempenho, na cultura organizacional e nos controles internos. O emprego da Teoria Fundamentada permitiu desenvolver conceitos sobre governança e gestão de TIC baseados nas documentações do SISP com conceituações sem premissas e vieses pessoais.
La frontera como intersticio: Reflexiones en torno a la violencia epistémica de las fronterizaciones
Authors: Stang Fernanda
Published: September 2020

Resumen Al hilo de inquietudes surgidas en el trabajo de campo de una investigación sobre procesos migratorios de colombianos y peruanos con subjetivaciones sexo-genéricas no heteronormativas, el artículo problematiza las fronteras aparentemente claras trazadas entre los atributos definidos para seleccionar a los sujetos del estudio: la relación tiempo-espacio implicada en el desplazamiento migratorio, y la subjetivación sexo-genérica “homosexual”. A partir de esas reflexiones, y de aportes de autores que han trabajado en torno a la noción, se propone un modo intersticial de pensar la frontera.
Gênero, sexualidades e deslocamentos: notas etnográficas sobre imigrantes e "refugiados LGBTI" no Norte do Brasil
Authors: França Isadora Lins , Fontgaland Arthur
Published: September 2020

Resumo Neste trabalho, partimos da emergência da categoria de “refugiados LGBTI” nos anos 2000 e de como ela tem operado no Brasil, para em seguida apresentar uma visão de conjunto em torno da literatura sobre o tema. Num segundo momento, tensionamos essa literatura mobilizando notas etnográficas de pesquisas realizadas num abrigo voltado para refugiados reconhecidos como “LGBTI” em Manaus e na Operação Acolhida em Boa Vista e em Pacaraima, na região Norte do Brasil. Além de oferecer uma contribuição desde a perspectiva antropológica para um tema relativamente novo no entrecruzamento entre refúgio, gênero e sexualidade, o artigo visa também contribuir para as pesquisas sobre as recentes migrações venezuelanas.
Dinámicas de (in)visibilidad en la migración LGTBIQ+: una cuestión comunicacional
Authors: Theodoro Hadriel , Cogo Denise , Bailén Amparo Huertas
Published: September 2020

Resumen Presentamos en este artículo un conjunto de reflexiones teóricas sobre las dinámicas de (in)visibilidad en la migración LGTBIQ+. Estas reflexiones están vinculadas al desarrollo de una investigación doctoral sobre el tema. El artículo, de carácter ensayístico, se basa en una revisión bibliográfica de la articulación de los estudios en comunicación, género y migración. En concreto, analizamos la dimensión comunicacional de esas relaciones y sus diferentes implicaciones en la movilidad (inter o transnacional) de los sujetos LGTBIQ+. En general, las prácticas comunicativas observadas se relacionan, por un lado, con la consabida precariedad y vulnerabilidad de los sujetos LGBTIQ+ y, por otro, con las luchas por el reconocimiento y la transformación social.
La construcción de las fronteras europeas como origen de la criminalización de las migraciones en Europa: retóricas de securitización y humanitarismo
Authors: Gorrín Ana Belén Estrada , Fuentes Lara María Cristina
Published: September 2020

Resumen El presente artículo realiza un breve recorrido histórico en torno a la construcción de las fronteras exteriores de Europa a partir del tratado de Schengen (1985). La progresiva desaparición de las fronteras interiores genera un estiramiento de las fronteras europeas, las cuales se construyen como espacios dinámicos justificando su continua reterritorialización allí donde se fundamenten cómo artefacto para garantizar la seguridad, y consecuentemente entendiendo la migración hacia Europa y dentro de esta como una amenaza. La gestión de las fronteras por la Unión Europea no se vincula a un discurso de odio, si bien en la actualidad sí existe un auge de las fuerzas políticas ultraderechistas en Europa, sino que debe basarse a nivel discursivo en una retórica de seguridad, pero también de humanitarismo. Sin embargo, las fronteras, como afirma Balibar (2003), son la condición absolutamente no democrática -o discriminatoria- de las sociedades democráticas.
Telessaúde em um centro de referência em Diabetes Mellitus: uma análise transversal
Authors: Schroder Ana Carolina , Vanz Ana Paula , Geremia César , Trindade Carolina Sturm , Canabarro Simone Travi
Published: September 2020

Resumo Objetivo Analisar uma ferramenta de telessaúde de um centro de referência em Diabetes Mellitus sob a ótica dos cuidadores. Método Estudo transversal, com abordagem quantitativa, desenvolvido em um centro de referência em Diabetes Mellitus, com cuidadores de crianças e adolescentes que utilizaram a Hot-Line e responderam ao questionário online, no período de novembro de 2018 a fevereiro de 2019. Resultados A amostra foi constituída de 90 participantes, sendo 76 (84,4%) do sexo feminino, tendo como o maior parentesco o materno 68 (75,6%). Quanto aos motivos das ligações, 31 (34,4%) referem-se às orientações gerais, 41 (45,6%) ao ajuste de dose de insulina, 6 (6,7%) à hipoglicemia aguda, 6 (6,7%) à hiperglicemia aguda, 2 (2,2%) aos dias de doença e 4 (4,4%) referem-se aos resultados de exames. Os participantes apresentaram um alto índice de satisfação com o uso da linha telefônica. Conclusão e implicações práticas O teleatendimento produz benefícios imediatos aos pacientes, sendo resolutivo no manejo da doença. Cabe ressaltar que o uso da telessaúde como forma de promoção da saúde contribui para a prevenção de agravos de maneira rápida, satisfatória e sem o deslocamento do paciente e sua família.
Fatores preponderantes para a internacionalização docente na pós-graduação em ciências sociais no Brasil
Authors: Maia João Marcelo Ehlert , Medeiros Jimmy
Published: September 2020

Resumo Nas últimas duas décadas ocorreu uma expansão dos programas de pós-graduação em ciências sociais e, ao mesmo tempo, uma crescente pressão, por parte das agências financiadoras, para a “internacionalização”. Tal processo não é isento de contradições, muitos já apontados na literatura, como a dificuldade de “internacionalizar” programas relacionados às humanidades. Neste sentido, o presente estudo discute os principais fatores explicativos da internacionalização de docentes das ciências sociais. Para tanto, desenvolve uma descrição dos aspectos relacionados à internacionalização da carreira dos professores e, ao final, identifica os fatores preponderantes para este processo, a partir de um survey on-line nacional. Os principais resultados são: realização de pós-doutorado no exterior é mais significativo para internacionalização do que doutorado sanduíche; antropologia tem indicadores de internacionalização maiores do que sociologia e ciência política, embora não seja possível inferir as causas; docentes de programas considerados como periféricos compensam a dificuldade de internacionalização com “estratégias de baixo custo”.
Constraint and Satisfiability Reasoning for Graph Coloring
Authors: Hebrard Emmanuel , Katsirelos George
Published: September 2020

Graph coloring is an important problem in combinatorial optimization and a major component of numerous allocation and scheduling problems. In this paper we introduce a hybrid CP/SAT approach to graph coloring based on the addition-contraction recurrence of Zykov. Decisions correspond to either adding an edge between two non-adjacent vertices or contracting these two vertices, hence enforcing inequality or equality, respectively. This scheme yields a symmetry-free tree and makes learnt clauses stronger by not committing to a particular color. We introduce a new lower bound for this problem based on Mycielskian graphs; a method to produce a clausal explanation of this bound for use in a CDCL algorithm; a branching heuristic emulating Br´elaz’ heuristic on the Zykov tree; and dedicated pruning techniques relying on marginal costs with respect to the bound and on reasoning about transitivity when unit propagating learnt clauses. The combination of these techniques in both a branch-and-bound and in a bottom-up search outperforms other SAT-based approaches and Dsatur on standard benchmarks both for finding upper bounds and for proving lower bounds.
Functional Movement Screening: An Early Detection of The Student Injury Risk in Sport Class
Authors: Syafei Muhamad , Budi Didik Rilastiyo , Listiandi Arfin Deri , Festiawan Rifqi , Kusnandar Kusnadar , Nurcahyo Panuwun Joko , Stephani Mesa Rahmi , Qohhar Wildan
Published: September 2020

Physical Education class is one of the solutions taken by regional schools to improve achievements in sports. The process of recruiting physical education class students has mostly conducted by using  the talent scouting test method which consists of physical test and skill test. However, the implementation of sport injury detection test using Functional Movement Screening (FMS) is still insignificant. The purpose of this study was to identify the student risk of injury in physical education class by using the FMS test. The research was an ex-post-facto method. The research samples were 32  students of class VIII in the physical education class at SMPN 1 Baturaden (20 males and 12 females) aged 14 years in average. The research instrument used was the Functional Movement Screening (FMS) test with the validity and reliability of 0.81. Data processing and analysis employed the Benchmark Reference (PAN) with the help of Ms. Excel. The results showed that 56.25% of physical education class students at SMPN 1 Baturaden were identified at risk of sports injuries. The results also showed an imbalance of strength between the right and left body muscles. The study  concludes that the use of Functional Movement Screening (FMS) test is important to minimize the high likelihood of injury of the students in physical education class.
Transformation of University Libraries During the Digital Era
Authors: Baryshev Ruslan A.
Published: September 2020

The paper considers the transition period of society development, based on the use of digital information and communication technologies. Now the digital economy covers all the spheres of society, so the question of its study is relevant. The transition to a new digital economy model contributes to improving the life quality of the population. In higher education institutions educational paths are changing, a rapid transition from physical to virtual reality is observed. However, the educational environment lags far behind the pace of industrial production based on modern technologies. In such situation, approaches to modernizing the training system need to be developed. This case university strategies, aimed at creating a full environment for the development of education and science, information and knowledge from the intellectual global environment, are being developed. In the context of the transition to digital technologies in education, the library, as one of the main structural divisions of the university, should also become digital. The paper reveals the different viewpoints of the library community that show the strategy and direction of library development for the digital environment. Libraries are now actively developing information and communications technology providing services to their users, while maintaining traditional forms and methods of working with readers. This symbiosis meets the needs of different groups of readers and users. On the basis of theoretical research of formation processes and development of electronic library, problems of transition period are considered, strategy of digital library development is identified, technologies of creation and introduction of information resources into university educational environment are determined. The purpose of the research was to study the activity of using information resources in the educational process and research activities, in order to improve the quality of service to library users. It will identify the attitudes of students towards information resources and library services. The relevance and importance of the transition to the digital library is noted, the impact of this process on the development of all library activities is analysed, while maintaining the continuity of its main functional purpose. In addition, the emergence of new social and technological tasks is indicated, the specifics of working with digital users are distinguished. The library works with both virtual users and real readers. Book loan and electronic resources to users are analyzed. The library’s activities are covered in educational and leisure activities with university students and teachers. In the article, the recommendations presented will improve the efficiency of the library
History of Complex Identity Research
Authors: Zamaraeva Yuliya S. , Koptseva Natalia P.
Published: September 2020

The article reveals conceptual problems of the formation of the concept of “complex identity” in modern humanities based on the analysis of foreign and Russian studies. In scientific history, the conceptual definition of the notion emerged in the last third of the 20th century in sociology and social psychology, however, since the beginning of the 21st century it received further development due to the interdisciplinary research, which allowed scientists to identify complex forms of identity in a dynamically developing world. At the beginning of the 21st century, the interest in identity as a cultural problem increased and it became necessary to study it in the context of modern culture and intercultural relations. Culturological problems allow us to combine existing ideas into a conceptual definition of the concept of “complex identity” and to prioritize research in accordance with modern socio-cultural relations
State Regulations and Elitisation: A Study of Civil Society Elites in Indonesia and Cambodia
Authors: Lay Cornelis , Eng Netra
Published: September 2020

This article analyses how and to what extent state regulation of civil society organisations (CSOs) have resulted in elitisation, i.e., the process of obtaining elite status within and beyond civil society. This is studied in the context of emerging democracy in Indonesia and shrinking civic space in Cambodia. Combining Bourdieu’s concepts of field and elite with strategic action fields, the article uses data from interviews with civil society leaders. It finds different patterns. In Indonesia, elitisation occurs through a process of CSO formalisation and bureaucratisation, with elites gaining legitimacy owing to their formal offices. As a result, competition for formal positions intensifies: This is particularly notable among national CSO leaders, who may shift their activities to the grassroots level to seek further empowerment and other capitals to legitimise their elite status, facilitate the rise of leaders in existing fields, and create pluralistic forms of elites. Regulations have also resulted in the marginalisation of non-formal elites and shifted the locus of legitimacy from activism to formalism. Meanwhile, in Cambodia, regulatory formalisation and bureaucratisation has not only reduced the space for elite competition and level of competitiveness, but also created ‘most dominant actors’ or ‘hyper-elites’ who are loyal to and support the regime and its priorities while punishing those who do not. This has resulted in a monolithic form of elites.
Pathways to Leadership within and beyond Cambodian Civil Society: Elite Status and Boundary-Crossing
Authors: Norén-Nilsson Astrid , Eng Netra
Published: September 2020

Elitisation in Cambodian civil society and how such processes relate to holding elite status in the state, electoral politics, and economic fields, is poorly understood. This article seeks to identify different pathways to becoming an elite within and beyond Cambodian civil society. We focus on four case studies, representing different forms of organisations within the sectors of agriculture and youth. Three main questions are explored. Firstly, we identify different forms of capital needed to reach elite status in civil society. Secondly, we explore how elite status within civil society is related to elite status within other fields, by identifying three pathways of boundary-crossing (Lewis, 2008a) from civil society into the state, electoral politics, and economic fields. Thirdly, we map the perceived possibilities and limitations of each field. In exploring these questions, this article argues for a reappraisal of Cambodian civil society, shifting attention to the networks and platforms that fall outside of the dominant focus on professional NGOs. By empirically tracing how elites move between fields, it aspires to provide a better understanding of the contours of, and relations between, civil society and other fields (including government, electoral politics, and business), including in terms of what particular forms of power pertain to each.
“REGIONAL HYDROCHEMISTRY OF UKRAINE” (2019) – A MODERN TEXTBOOK ON THE STUDY OF THE CHEMICAL COMPOSITION OF SURFACE, GROUNDWATER AND SEA WATERS IN THE COUNTRY
Authors: Zabokrytska M.R.
Published: September 2020

The article reviewed and analyzed the textbook “Regional Hydrochemistry of Ukraine” (authors V.K. Khilchevskyi, V.I. Osadchyi, S.M. Kurylo), published in 2019. The textbook comprehensively summarizes and covers materials on the hydrochemistry of precipitation, rivers, lakes, reservoirs and ponds, underground and sea waters in Ukraine. The authors used the latest results of studies of the chemical composition of water of various water bodies in the country, applied the hydrochemical characteristics of the river basin districts according to the modern hydrographic zoning of Ukraine (2016), which takes into account the requirements of the European Union Water Framework Directive (WFD 2000/60/EC).
A feature of the textbook is that the authors were largely based on the materials of their own studies of the chemical composition of surface waters. They also systematized and generalized the monographic works of leading Ukrainian scientists, in different years (from the 1950s to the present day) they studied fundamental and applied issues of hydrochemistry of surface, underground and sea waters. The structure of the textbook consists of a preface, 11 sections, applications and a list of references. The textbook is intended for students of the specialty “Earth Sciences”, studying in educational programs of hydrological, hydroecological and hydrogeological profile. It may be useful for students of the specialty “Geography”, students in educational programs of a physical-geographical and geo-ecological profile.
Verification of a labor market domain using an academic crowdsourcing system
Authors: Azofeifa Esteban J. , Novikova Galina M.
Published: September 2020

Students desiring to become a valuable good in the labor market are willing to pay a considerable monetary cost to obtain knowledge about their prospective job opportunities, nowadays with a diminishing interest in the obtainment of a diploma. Considering the behavior of the labor market as a domain theory under uncertainty, it is straightforward to expect the presence of contradictions, in the form of salaries unable to be classified due to high inconsistency and variation. We provide an algorithm to verify a labor market domain theory based on a crowdsourcing academic system, in which feedback about possible contradictions is generated as a result of consultations with experts inside of the market and clustered into different contexts. We found that the verification process can be repeated iteratively as long as the students overall tuition is equal or greater than a quantity partially defined by the number of different profiles of the students.
INFLUENCE OF FAMILY ON FORMATION ON THE IDENTITY OF THE CRIMINAL
Authors: Dikusar Ya. S.
Published: September 2020

The paper sets an approach to the definition of the family as a social system, considers the concept of family identity, which is one of the factors of the favorable influence of the family on the formation of the child’s personality. The structure of the family identity of minors is revealed, its most significant factors are determined. The article examines in detail such a component of the structure of family identity as family cohesion. The author also presents data from a survey of adolescent delinquent and normative behavior using the «Family Cohesion and Adaptation Scale» (FACES-3), analyzes them, identifies the types of families of juvenile delinquents, and presents the results of a study of the family identity of juvenile delinquents in a table form. Using t-student test, statistically significant differences were revealed between the prevailing types of families of adolescents with delinquent behavior and adolescents with normative behavior. As a result of the work, the author of the article emphasizes that the lack of a sense of adolescents' connection with the family, acceptance by the family, satisfaction with their family complicates their social development situation and can lead to illegal behavior. The author also makes brief recommendations on overcoming family disunity to form a cohesion factor as an indicator of family identity.
PHONON SPECTRAL ENERGY DENSITY IN METALSWITH THE CUBIC LATTICE STRUCTURE
Authors: Orlov A. V. , Zelenskiy V. I.
Published: September 2020

This study derives an expression of spectral energy density of acoustic phonons, as well as introducing the basic properties of anharmonic phonons and deriving an expression of their spectral energy density. The description of the vibrations of the atoms of the crystal lattice to this day cannot be considered completely finished, despite the existence of the theory of heat capacity at a constant volume (Debye theory). Debye's theory perfectly explains the law of cubic increase in heat capacity with temperature at low values of the latter. However, at high temperatures, the Debye model seems insufficiently substantiated. In particular, it is not clear for what physical reasons the value of the critical frequency was introduced - the phonon frequency, above which their appearance is impossible. In addition, the spectral energy density of anharmonism phonons is not considered, although this information is extremely important. It is the spectral composition of the anharmonic phonons that is necessary for an objective description of the phonon-phonon interaction in a crystal. In this paper, the principles are stated on the basis of which the spectral energy density of phonons can be calculated. The consideration is carried out for a simple cubic crystal lattice.
Mechanisms of cytotoxic action of a series of directionally synthesized heterocyclic hydroxamic acids
Authors: Neganova M.E. , Aleksandrova Yu.R. , Pukhov S.A. , Klochkov S.G. , Osipov V.N.
Published: September 2020

Cyclic hydroxamic acids based on quinazoline-4(3H)-one and dihydroquinazoline-4(1H)-one have been synthesized. The antioxidant and iron-chelating properties of these compounds, their effect on the activity of the histone deacetylase enzyme, and their cytotoxic effect on cells of various tumor lines have been investigated. We have identified two compounds-hits, which exhibit the multipharmacological type of the antineoplastic activity. Their cytotoxic effect on cells of human lung carcinoma A549 and breast adenocarcinoma MCF-7 is obviously associated with their ability to modulate the level of reactive oxygen species and to chelate Fe(II) ions, as well as to inhibit the metalloenzymes, histone deacetylases, involved in the epigenetic regulation of tumor genesis. Thus, the synthesized hydroxamic acids may be considered as a promising basis for creating potential oncolytics.
Estudiantes LGBT+ y profesores universitarios. Prácticas de inclusión y exclusión en la educación superior
Authors: Espinoza Romero Migdelina Andrea , Rodríguez Jiménez José Raúl
Published: September 2020

The purpose of this work was to explore the interactions between university professors and LGBT+ higher education students. The majority of participants considered that professors abused their power: they practiced negative academic leadership, imposed clearly heteronormative interactions in the classroom, discriminating and despising students who differ from this pattern, which affected these students academically and emotionally. Only in a few cases, respondents described professors who developed inclusive pedagogical practices. The empirical information that supported this work came from 31 interviews conducted with sexually diverse higher education students enrolled in 11 higher education institutions in Sonora, Mexico.
Ocular side effects of anti-tubercular drugs in patients receiving Anti-Tb treatment at tertiary care center
Authors: Panchal Kruti , M Solu Trupti
Published: September 2020

India is among the countries that carry the highest burden for tuberculosis. Antitubercular drugs are frequently associated with ocular toxicity. Among ATT, ethambutol is the most commonly implicated drug causing optic neuropathy. For assessing spectrum of ATT induced ocular toxicity, clinical presentation, monitoring, and preventive measures a prospective observational follow up study was conducted.

A newly diagnosed drug susceptible pulmonary tuberculosis patients referred to ophthalmology OPD during a study period from May 2018 - October 2019 at a tertiary care hospital. The detailed history, best corrected visual acuity, fundus examination, color vision test and visual fields were carried out in all patients at the start of treatment and thereafter every month up to 6 months after initiation of ATT.

During six month follow up study, out of 94 study participants, 14 eyes of seven patients (7.44%) had drop in visual acuity from baseline (p value = 0.03). Total 10 eyes of five patients (5.32%) had developed colour vision abnormality (p=0.001) and 8 eyes of four patients had developed optic disc changes from baseline. Visual field defects were noted in ten (5.32%) eyes (p = 0.001). In our study ATT related ocular toxicity was found in 5.32% on standard HRZE drug regimen.

The course of ethambutol-induced ocular toxicity is unpredictable. The early recognition of ocular toxicity is paramount to prevent irreversible visual loss.