bluuebunny/crossref_metadata_2025 huggingface dataset:
Nicotinic acid protects germinal vesicle oocyte meiosis in mice and humans against toxicity of benzo(a)pyrene during maturation
Authors: Gao Min , Li Dungao , Zhan Shaoquan , Qiu Yanling , Chen Bohong , Cao Tianqi , Huang Jun jiu , Chen Zhiyun
Published: May 2023

BackgroundApproximately 5 nM -7 nM internal exposure concentration of BaP was detected in women who mainstream smoke or suffering assisted reproductive failure. In this study, we evaluated the effects of benzo(a)pyrene (BaP) on mouse and human germinal vesicle (GV) oocyte maturation in 5 nM BaP. Then, we tested whether nicotinic acid (NA) could restore GV meiotic failure caused by the BaP or not during in vitro maturation (IVM)?MethodsClinically discarded GV oocytes from young women (aged < 35 years) undergoing intracytoplasmic sperm injection (ICSI) / in vitro fertilization (IVF) and GV oocytes from 6–8 weeks old female CD1 mice were used. Oocyte quality was estimated by GV oocyte maturation, morphological observation, and mitochondrial functions. The subcellular structures were further evaluated using immunostaining, fluorescent intensity quantification or western blot to analyze spindle organization, chromosome arrangement, actin polymerization, mitochondrial distribution, DNA damage and the Sirt1 protein level during mouse oocyte meiotic.ResultsWe found 5 nM/50 nM BaP exposure significantly reduced first polar body extrusion during mouse GV oocytes maturation. Sirt1 protein expression decreased after BaP treatment in mouse oocytes. Moreover, BaP exposure disorganized spindle and chromosome arrangement, disrupted cortical actin cap, impaired mitochondrial redistribution, and caused DNA damage in IVM metaphase II (MII) mouse oocytes. Importantly, NA supplementation (15µM) increased Sirt1 expression and significantly rescued most of the abnormal effects. We then explored the effect of 5 nM BaP on human GV oocytes, a concentration close to that in human ovarian follicular fluid, and found that BaP caused GV meiotic failure by increasing mitochondrial membrane potential and markedly elevating reactive oxygen species (ROS) levels. Finally, we showed that 15 µM NA supplementation partially rescued human GV oocytes from the toxicity of 5 nM BaP during IVM.ConclusionsCollectively, our study indicated that internal exposure concentrations of BaP could seriously disrupt GV oocyte IVM and caused GV meiotic defects in both mouse and human. NA partially protected GV oocyte meiosis against toxicity of BaP during IVM.
RACK1 mediates NLRP3 inflammasome activation during Pasteurella multocida infection
Authors: Ran Jinrong , Yin Hang , Xu Yating , Wang Yu , Li Gang , Wu Xingping , Peng Lianci , Peng Yuanyi , Fang Rendong
Published: May 2023

Pasteurella multocida is gram-negative bacteria that causes serious diseases in a wide range of animal species. Inflammasome as an intracellular multimolecular protein complex plays a critical role in host defense against microbial infection. Our previous study showed that bovine Pasteurella multocida type A (PmCQ2) infection induces NLRP3 inflammasome activation. However, the exact mechanism of PmCQ2-induced NLRP3 inflammasome activation is less studied. Here, we show that NLRP3 inflammasome activation is positive regulated by a scaffold protein called receptor for activated C kinase 1 (RACK1). This study showed that RACK1 expression was downregulated by PmCQ2 infection in mice primary peritoneal macrophages and mice tissues while overexpression of RACK1 rescued PmCQ2-induced cell death, indicating the positive role of RACK1 in the host. Next, RACK1 knockdown by si-RNA significantly attenuated PmCQ2-induced NLRP3 inflammasome activation with the reduction of protein expression of interleukin (IL)-1β, pro-IL-1β, caspase-1 and NLRP3 as well as the formation of ASC specks while RACK1 overexpression by pcDNA3.1-RACK1 plasmid transfection significantly promoted PmCQ2-induced NLRP3 inflammasome activation, indicating RACK1 is essential for NLRP3 inflammasome activation. Furthermore, RACK1 knockdown decreased PmCQ2-induced NF-κB activation but RACK1 overexpression increased its activation. In addition, results of immunofluorescence staining and immunoprecipitation showed that RACK1 colocalized with NLRP3 and NEK7 and interacted with them. However, blockage of potassium efflux significantly attenuated RACK1-NLRP3-NEK7 interaction. Our study demonstrated that RACK1 plays an important role in promoting NLRP3 inflammasome activation by regulating NF-κB and promoting the NLRP3 inflammasome assembly.
KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors
Authors: Zhou Yan , Zhang Bo , Zhao Chen , Shen Wenchen , Li Wei , Zheng Yue , Kong Xiangfei , Wang Junbao , Wu Xudong , Zeng Tao , Liu Ying
Published: May 2023

The hippocampus plays major roles in learning and memory, and its formation requires precise coordination of patterning, cell proliferation, differentiation, and migration. Here we removed the chromatin-association capability of KDM2B in the progenitors of developing dorsal telencephalon (Kdm2b∆CxxC) to discover that Kdm2b∆CxxC hippocampus, particularly the dentate gyrus, became drastically smaller with disorganized cellular components and structure. Kdm2b∆CxxC mice displayed prominent defects in spatial memory, motor learning and fear conditioning, resembling patients with KDM2B mutations. The migration and differentiation of neural progenitor cells was greatly impeded in the developing Kdm2b∆CxxC hippocampus. Mechanism studies revealed that Wnt signaling genes in developing Kdm2b∆CxxC hippocampi were de-repressed due to reduced enrichment of repressive histone marks by polycomb repressive complexes. Activating the Wnt signaling disturbed hippocampal neurogenesis, recapitulating the effect of KDM2B loss. Together, we unveiled a previously unappreciated gene repressive program mediated by KDM2B that controls progressive fate specifications and cell migration, hence morphogenesis of hippocampus.
Big Data Analytics in the Healthcare Sector: Opportunities and Challenges in Developing Countries. A Literature Review
Authors: Muhunzi David , Kitambala Lucy , Mashauri Harold
Published: May 2023

Background: The availability of vast amounts of healthcare data, along with the advancements in big data analytics techniques, has led to an unprecedented opportunity for healthcare organizations to improve patient outcomes and reduce healthcare costs. Despite the ongoing digitization of healthcare sector in developing countries, the full adoption of big data analytics in healthcare and the effective realization of its potential benefits still need to be reached. Exploring opportunities and challenges encountered in implementing data analytics in healthcare in developing countries is essential for designing implementation strategies and interventions.
Objective:Exploring opportunities and challenges towards integrating big data analytics technologies in the healthcare industry in developing countries.
Methodology: A literature search was conducted in PubMed, Science Direct and Google Scholar with the keywords "big data analytics", "big data analytics healthcare", "big data analytics healthcare developing countries", "healthcare data analytics", and "healthcare data analytics developing countries". Articles with predetermined keywords and written in English were included in the review.
Results:Big data analytics finds its application in medical images analysis and imaging informatics, population health management, clinical informatics and bioinformatics, as decision support algorithms even in developing countries. The major challenges to the clinical adoption of big data analytics in healthcare in developing countries include the need for more evidence for its practical benefits, competing priorities, the lack of trained personnel for analyzing big healthcare data and the lack of substantial financial investment required.
Conclusion:Integrating big data analytics in developing countries’ healthcare industry can potentially open new avenues for enhancing healthcare delivery. Despite the benefits big data analytics can have in the healthcare industry of developing countries, highlighted strategies should be implemented to address several challenges encountered towards using this technology.
Associations between Probiotic Exposure and yogurt consumption with Hepatic Steatosis: A nationwide cross-sectional study
Authors: Song Yancheng , Guo Wencong , Wang Junke , Liu Shuguang , Li Zhaopeng , Li Zhao , Guo Dong , Li Yu
Published: May 2023

Background Recent research showed that probiotics treatment may reduce insulin resistance, regulate lipid metabolism, raise liver enzyme levels, and ameliorate inflammation in individuals with non-alcoholic fatty liver disease (NAFLD). However, the association between probiotic use and hepatic steatosis in people has not been identified. The purpose of this study was to investigate the possible relationship between probiotic exposure and hepatic steatosis.Methods The cross-sectional research was conducted among adults with complete data on probiotic exposure and hepatic steatosis in the 2011–2016 National Health and Nutrition Examination Survey (NHANES). Probiotic exposure was assessed using a dietary supplement questionnaire. Hepatic steatosis was evaluated with hepatic steatosis index (HSI). Weighted multivariable regression analysis, subgroup analysis, and interaction analysis were conducted to explore the independent relationship between probiotic exposure and hepatic steatosis. The restricted cubic spline (RCS) was used to analyze the curve association between yogurt and hepatic steatosis.Results A total of 7891 participants were included in the study represented 146.7 million non-institutionalized residents of the United States, of whom 4322 (54.77%) were diagnosed with hepatic steatosis. Multivariable logistic regression showed probiotic exposure had significantly inverse associations for hepatic steatosis (OR = 0.84, 95% CI: 0.72–0.97, P = 0.02) after adjusting for all covariates. Once more, the independent relationship between probiotic exposure and hepatic steatosis was verified by subgroup analysis and interaction analysis. The restricted cubic spline model demonstrated a robust J-shaped link between yogurt and hepatic steatosis, revealing a significant decrease in risk within the lower range of yogurt, which attained the lowest risk close to 0.4 cup.Conclusions These results suggested that probiotic exposure may have beneficial effects for hepatic steatosis, along with a J-shaped relationship between yogurt and hepatic steatosis. This study recommends that people take half a cup of yogurt daily. Further research is required to identify the mechanistic relationships between probiotics exposure and hepatic steatosis.
Impact of long-lasting insecticidal nets on resting and feeding behaviour of Anopheles fluviatilis and Anopheles culicifacies (Diptera: Culicidae), the vectors of malaria in East- Central India
Authors: Sahu S. S. , Gunasekaran K. , Shriram A. N. , Panigrahi D. K. , Baig Mohammed Mustafa , Krishnamoorthy N. , Mathivanan A. , Kumar B Vijaya , Rahi Manju , Kumar Ashwani
Published: May 2023

Background & Objectives: Currently, the malaria control strategies in Odisha to achieve the goal of malaria elimination rely on long-lasing insecticidal nets. Shifting of behaviour in anopheline vectors poses a significant challenge for elimination of malaria. This manuscript discusses the shift in the behaviour of two primary vectors of malaria; Anopheles fluviatilis James s. l. and Anopheles culicifacies Giles s. l. after universal coverage of LLINs in Odisha State during 2017.
Methods: Mosquito collections were made fortnightly from the selected villages of Koraput and Malkangiri districts of Odisha State from April 2019 to March 2021. The entomological parameters; density, parity, sibling species composition, infection and human blood index of two malaria vectors and epidemiological parameters such as malaria incidence were assessed.
Results: The PMD of An. fluviatilis was zero in human dwellings in both the districts and the average PMD in cattle sheds was 1.5 in Koraput and 0.01 in Malkangiri district. In Koraput district, the average PMD of An. culicifacies was zero in human dwellings and 7.0 in cattle sheds and the corresponding values in Malkangiri district was 2.2 and 10.1, respectively. The foot-hill and plain ecotypes had a significantly greater abundance of An. fluviatilis and An. culicifacies, respectively. While winter season was the favourable period for the abundance of An. fluviatilis, both summer and rainy seasons are favourable period for An. culicifacies. The HBI of An. fluviatilis and An. culicifacies was 0.01 and 0.007, respectively.
Discussion: A shift in the resting behaviour of An. fluviatilis from human dwellings to cattle sheds and feeding behaviour from anthropophagy to zoophagy, change in sibling species composition from species S to T and reduction of vector infection status to zero was observed in this study. None was found positive for malaria in the study villages.
Conclusion: The study highlighted the necessity of continuing the ongoing vector control tool, i.e. LLINs for effective control of malaria.
Colchicine-induced Jasminum sambac Polyploids Secured Altered Metabolic Profile with Unique Antifungal Compounds
Authors: S Vishnupandi , M Ganga , K Rajamani , R Kannan , S Manonmani , Ashraf Suhail , Boopathi Manikanda
Published: May 2023

Cercospora leaf spot is one of the critical foliar fungal diseases of jasmine, which causes considerable yield losses. There are no cultivars or germplasm accessions that are resistant to this infection and hence fungicide usage is the mainstay of management of this disease, which poses a hazard to the environment. Polyploidization is one of the key breeding methods in jasmine as newly obtained polyploids may have increased resistance/tolerance to diseases owing to altered metabolite production. In the present study, seventeen putative polyploids were obtained from Jasminum sambac Cv. Ramanathapuram Gundumalli by treating with the polyploidizing agent, colchicine. Among them, two mutant plants (generated from the wild parent following treatment with 0.25% colchicine) exhibited no symptoms for Cercospora leaf spot, whereas the control had the highest mean PDI (63.65%). Non-targeted metabolite profiling experiment indicated that couple of antifungal compounds (such as 1H-1,2,4-Triazole-1-ethanol, α-butyl-α-(2,4-dichlorophenyl) and Dasycarpidan-1-methanol, acetate (ester)) were present only in the two newly evolved mutants of J. sambac and absent in wild parent. Molecular docking results have shown that the compound Dasycarpidan-1-methanol, acetate (ester) binds effectively with two fungal proteins 7EUS and 7EUT, which are actively involved in biosynthesis of cercosporin (which is a photoactivated toxin that uses reactive oxygen species (ROS) in host cells and damage cell components such as membranes, proteins and lipids). Thus, this study enabled the development of a natural and eco-friendly method of evolving and characterizing novel lines in jasmine, which would have potential applications in flower industry.
On numerical equivalence of parallel generalized solutions of mixed boundary value problem of annulus
Authors: Lin Luobin , Chen Fuquan , Huang Xianhai
Published: May 2023

This paper provides two parallel generalized solutions on a fundamental mixed boundary value problem that a unit annulus is subjected to a partially fixed outer periphery and an arbitrary traction acting along the inner periphery by using the complex variable method. The mixed problem is transformed into two parallel Riemann-Hilbert problems with respective sets of different mathematically rigorous boundary conditions, which are solved by successive approximation method with the Lanczos filtering technique to obtain numerically equivalent stress and displacement results. Four typical numerical cases coded by FORTRAN are carried out and compared to the same cases performed on ABAQUS to validate these two parallel solutions. Based on the case results, the detailed reasons of numerically equivalence between these two parallel solutions are analytically elaborated and several insights of the application of the complex variable method are revealed.
Migrant Men’s Views and Experiences towards Female Genital Mutilation/Cutting (FGM/C) and its Prevention and Care in OECD Countries: A Qualitative Systematic Review Protocol
Authors: Dwira Mark Hayford
Published: May 2023

Objective This review aims to synthesize male migrants’ views and experiences about the provision of care services for survivors of FGM/C and related-prevention strategies in healthcare settings in OECD countries.Introduction: Concerns among survivors about FGM/C care access relate to the potential impact of newly enacted laws in the healthcare service delivery and whether their decisions to seek care are acceptable by their current or future male partners. Little is known of their male partners’ views.Inclusion criteria: The review will consider articles that included male migrants of all ages who have close relationships with survivors and live in OECD countries. In studies comprising (men and women), where perspectives of men are reported separately, they will be included. Non-OECD countries’ studies will be excluded.Methods The databases to be searched will include Ovid MEDLINE, EBSCOhost, CINAHL, ASSIA, Ovid Embase, PsycINFO, Cochrane library, JBI Databases and hand searching of relevant journals. Unpublished studies will be searched through OpenGray and websites of national and international organisations working on FGM/C, including the National Health Services and World Health Organisation. The search will identify English-language publications from January 2002 onwards. Titles and abstracts will be reviewed first, and then full texts will be screened by two independent reviewers against the inclusion criteria. Any disagreements will be resolved through discussion or a third reviewer. The result will be critically appraised for methodological quality. Data extraction results will be synthesised and evaluated for credibility and dependability.Systematic review registration number: PROSPERO: CRD42019155518
User experience of a family health history chatbot: A quantitative analysis
Authors: Allen Caitlin
Published: May 2023

Objective: Family health history (FHx) is an important tool in assessing one’s risk towards specific health conditions. However, user experience of FHx collection tools is rarely studied. ItRunsInMyFamily.com (ItRuns) was developed to assess FHx and hereditary cancer risk. This study reports a quantitative user experience analysis of ItRuns.
Methods: We conducted a public health campaign in November 2019 to promote FHx collection using ItRuns. We used software telemetry to quantify abandonment and time spent on ItRuns to identify user behaviors and potential areas of improvement.
Results: Of 11065 users who started the ItRuns assessment, 4305 (38.91%) reached the final step to receive recommendations about hereditary cancer risk. Highest abandonment rates were during Introduction (32.82%), Invite Friends (29.03%), and Family Cancer History (12.03%) subflows. Median time to complete the assessment was 636 seconds. Users spent the highest median time on Proband Cancer History (124.00 seconds) and Family Cancer History (119.00 seconds) subflows. Search list questions took the longest to complete (median 19.50 seconds), followed by free text email input (15.00 seconds).
Conclusion: Knowledge of objective user behaviors at a large scale and factors impacting optimal user experience will help enhance the ItRuns workflow and improve future FHx collection.
Procedural sedation and/or analgesia: a review
Authors: Leshchenko R. E. , Levit A. L. , Davydova Nadezhda S.
Published: May 2023

INTRODUCTION: In recent decades procedural sedation and/or analgesia (PS/PSA) have been widely used for diagnostic examinations and minimally invasive surgical interventions outside of the operating room. The recommendations for (PS/PSA) presented in the literature contain contradictory data related to indications, contraindications, baseline monitoring level, priority level and sedation protocols. OBJECTIVE: To perform an analysis of current practice guidelines, randomized clinical trials (RCTs), literature review and to systematize data on the potential use of sedatives and narcotic analgesics in procedural sedation. MATERIALS AND METHODS: PubMed, Medline, Embase, and eLibrary were searched for PS/PSA guidelines, RCTs, and articles. RESULTS: The literature review describes the levels of sedation in increase in difficulty and potential risk of complications. A comparative characteristic of first- and second-line drugs for sedation and anesthesia is presented. Minimum requirements for perioperative monitoring of vital signs, sedation and pain levels are formulated. CONCLUSIONS: The PS/PSA in a planned or emergency procedure provides safe, comfortable and successful performance of diagnostic examinations and mini-invasive surgical interventions. The principles of interaction and administration of sedatives with narcotic analgesics are the basis for the use of sedation regimens. The use of scales has important practical value for monitoring the dynamics of sedation levels and for more fine management of sedation doses. There are no absolute contraindications for PS/PSA. PS/PSA is a popular area of practice for the anesthesiologist and resuscitator today. The Russian Federation's lack of regulatory documents on PS/PSA makes it necessary to develop guidelines.
Self-binding of one-dimensional fermionic mixtures with zero-range interspecies attraction
Authors: Givois Jules , Tononi Andrea , Petrov Dmitry
Published: May 2023

For sufficiently large mass ratios the attractive exchange force caused by a single light atom interacting with a few heavy identical fermions can overcome their Fermi degeneracy pressure and bind them into an N+1N+1 cluster. Here, by using a mean-field approach valid for large NN, we find that N+1N+1 clusters can attract each other and form a self-bound charge density wave, the properties of which we fully characterize. Our work shows that there are no fundamental obstacles for having self-bound states in fermionic mixtures with zero-range interactions.
INTUSSUSCEPTIONIS IN ADULT, CASE REPORT OF ACUTE INTUSSUSCEPTIONON DUE TO METASTASIS FROM A TESTICULAR TUMOR
Authors:   CHU Mohamed VI, Marrakech Faculty of Medicine and Pharmacy, Cadi Ayyad University of Marrakech., Ait Ben Addi Rachid , Ait Blaid Wafae ,   CHU Mohamed VI, Marrakech Faculty of Medicine and Pharmacy, Cadi Ayyad University of Marrakech., Ahbala Tariq ,   CHU Mohamed VI, Marrakech Faculty of Medicine and Pharmacy, Cadi Ayyad University of Marrakech., Rabbani Khalid ,   CHU Mohamed VI, Marrakech Faculty of Medicine and Pharmacy, Cadi Ayyad University of Marrakech., Louzi A. Abdelouahed ,   CHU Mohamed VI, Marrakech Faculty of Medicine and Pharmacy, Cadi Ayyad University of Marrakech.
Published: May 2023

Intestinal intussusception is a rare pathology in adulthood and often secondary to an organic cause, reporting the observation of a young 36-year-old patient with no particular pathological history, who was diagnosed with intussusception due to metastasis of a testicular tumor.
CO2 AND H2S REMOVAL FROM BIOGAS BY USING FOUR MEMBRAN OF INTEREST
Authors:   Department of Energy, National Higher Institute of Industrial Technology of the National University of Sciences, Technologies, Engineering and Mathematics of Abomey (INSTI/UNSTIM), BP 133, Republic of Benin., D. F. Adamon Gildas , Aviansou G. ,   Department of Energy, National Higher Institute of Industrial Technology of the National University of Sciences, Technologies, Engineering and Mathematics of Abomey (INSTI/UNSTIM), BP 133, Republic of Benin., G. Godjo Thierry ,   Department of Energy, National Higher Institute of Industrial Technology of the National University of Sciences, Technologies, Engineering and Mathematics of Abomey (INSTI/UNSTIM), BP 133, Republic of Benin., Sodokin NDedji R. ,   Department of Energy, National Higher Institute of Industrial Technology of the National University of Sciences, Technologies, Engineering and Mathematics of Abomey (INSTI/UNSTIM), BP 133, Republic of Benin., Sylla M. ,   Energy4Impact, Benin, Fidjrosse, Villa nÃ‚Â°180, BP 633, Cotonou Republic of Benin., Agonman A. ,   Department of Energy, National Higher Institute of Industrial Technology of the National University of Sciences, Technologies, Engineering and Mathematics of Abomey (INSTI/UNSTIM), BP 133, Republic of Benin., T. Guidi Clotilde ,   Department of Energy, National Higher Institute of Industrial Technology of the National University of Sciences, Technologies, Engineering and Mathematics of Abomey (INSTI/UNSTIM), BP 133, Republic of Benin.
Published: May 2023

Biogas upgrading in Africa remains a huge challenge for producers of small installations due to the high cost of acquisition of all-in-one installations designed and used in developed countries. This study brings a clear idea on some purification methods accessible to these small producers while proposing those optimal for decarbonation and desulphurization of biogas. Starting from the analysis over time of the biogas resulting from the anaerobic digestion of cow dung, the system of NaOH filters and steel wool mounted in series is the one proposed for optimality (with purification capacities respective CO2 of the order of 95.9063 Ã‚Â± 0.0864 % and H2S of 100 %). Better still, the use of a steel wool filter in series with activated carbon (based on coconut shells or bamboo) makes it possible to increase the desulfurization capacity of the latter up to 100 %.
LA CONSULTATION DANNONCE DE CANCER ENTRE REALITES ET PERSPECTIVES
Authors:   Departement de Radiotherapie, Institut national doncologie, Maroc., Nouni K. , Fares H. ,   Departement de Radiotherapie, Institut national doncologie, Maroc., Elmajjaoui S. ,   Departement de Radiotherapie, Institut national doncologie, Maroc., Kebdani T. ,   Departement de Radiotherapie, Institut national doncologie, Maroc., Elkacemi H. ,   Departement de Radiotherapie, Institut national doncologie, Maroc., Hassouni K. ,   Departement de Radiotherapie, Institut national doncologie, Maroc.
Published: May 2023

The announcement of the diagnosis of cancer represents a fundamentalstep in the patientshistory, it conditions the quality of the bond of trust with the doctor and requiresveryspecial attention. It is for thisreasonthat the announcement consultation must beidentified in the course of care for cancer patients. The objective of oursurvey of 80 patients followed in the radiotherapydepartment at the National Institute of Oncologyis to analyze the methods of announcing cancer and the feelings of patients in order to target possible points for improvement for a better care whileaddressingsomepsychological and communicationalcharacteristics of the announcement of bad news, ethicalconsiderations and regulatory and deontologicalframeworksthat structure thisapproach in Morocco.
PARANEOPLASTIC DERMATOMYOSITIS REVEALING OVARIAN CANCER: ABOUT A CASE
Authors:   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech., Oualla Jamila , Bahbouhi Imane ,   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech., Oujennane Khadija ,   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech., Harou Karam ,   Department of Gynecology, Universitary Hospital, Marrakech, Morocco., Aboudourib Maryem ,   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech., Hocar Ouafa ,   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech., Amal Said ,   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech.
Published: May 2023

Dermatomyositis (DMs) is a systemic autoimmune disease affecting mainly muscle and skin. It may be associated with cancer in a paraneoplastic setting with a frequency ranging from 18 to 32% [1]. various types of cancer are described in the literature however, the association with gynecological cancers, especially in women, is more frequent. the incidence of ovarian cancer in dermatomyositis in women is 13.3% it is higher than in the general population (1%) [2]. We present the case of a patient with paraneoplastic dermatomyositis, who presented with a typical clinical symptomatology of paraneoplastic dermatomyositis, confirmed by other complementary examinations (creatine phosphokinase (CPK) + EMG (electromyogram) + skin biopsy). Etiological exploration by the ovarian specific tumor marker CA 125, and pelvic ultrasound completed by pelvic MRI oriented the diagnosis towards ovarian adenocarcinoma. Our results suggest that a complete gynecological workup including gynecological clinical examination, CA 125, CA 15-3 and pelvic ultrasound should be routinely performed in any woman over 40 years of age with DM.
AN INNOVATIVE DEVICE FOR TMJ VIBRATION ANALYSIS
Authors:   Junior Resident, Department of Prosthodontics and Crown & Bridge Government Dental College, Thiruvananthapuram, Kerala., M.U Shayistha , V. Nair Vivek ,   Professor, Department of Prosthodontics and Crown & Bridge Government Dental College Thiruvananthapuram, Kerala., Harshakumar Karunkaran ,   Professor & Head, Department of Prosthodontics and Crown & Bridge Government Dental College, Thiruvananthapuram, Kerala., Ravichandran Rajagopal ,   Professor, Department of Prosthodontics and Crown & Bridge Government Dental College, Thiruvananthapuram, Kerala.
Published: May 2023

Temporomandibular joint (TMJ) sounds are an important sign of temporomandibular disorder. Vibrations of different frequencies have been linked to certain types of disorders of the TMJ. Commercially available instrumentsemployed to record the vibrations of the TMJ are expensive and impractical to purchase in a clinical setup or for educational purposes. This article describes the development of a novel, innovative and inexpensive device using a pair of accelerometers, microphones and smartphones along with a developed software for the purpose of recording and analysing the recorded data from the TMJ.
SEMANTIC ANALYSIS OF ARABIC LOANWORDS IN MALAYSIAN POLITICAL DISCOURSE
Authors:   Associate Professor at the Research Centre for Arabic Studies and Islamic Civilization, Faculty of Islamic Studies, UniversitiKebangsaan Malaysia., Abu Bakar Kaseh , Al-Hadi Ab Hadi Amin ,   Masters candidate at the Research Centre for Arabic Studies and Islamic Civilization, Faculty of Islamic Studies, UniversitiKebangsaan Malaysia., Azwan Kamarudin Mohamad ,   Arabic Language Teacher at Faculty of Islamic Studies, UniversitiKebangsaan Malaysia., Hamdan Iqbal ,   Masters Candidate at the Research Centre for Arabic Studies and Islamic Civilization, Faculty of Islamic Studies, UniversitiKebangsaan Malaysia.
Published: May 2023

Loanwords are words borrowed from one language and incorporated into another. They may originate from a wide range of languages and can be modified to adhere to the phonological and grammatical conventions of the receiving language. The Malay language consists of a vast number of words borrowed from various languages, including Arabic. Arabic loanwords have helped develop the Malay language by enriching and diversifying its vocabulary. While Arabic loanwords are used extensively within the Islamic religious context, they are also employed in other fields, including politics. In Malaysia, where Malay is the official language, the use of Arabic loanwords is common in the political sense. Some Arabic loanwords related to politics have become so integrated into Malay that the pronunciation no longer sounds foreign, while others maintain the sound characteristics of Arabic. This study analyzed the use of Arabic loanwords in the current Malaysian political discourse via mainstream media, specifically newspapers and political blogs, from 2022 to 2023. The Arabic loanwords were then comparatively analyzed in terms of their lexical meaning in the donor and receiving language, as well as their contextual meaning in Malaysian politics. The findings of this study suggest that the intermixing between Islam and politics in Malaysia may have fueled the pervasiveness and trendiness of the use of Arabic loanwords in lieu of equivalent native words and loanwords of English origin, and competing loanword equivalents which have been phonologically modified.
HYDATID CYST OF THE LIVER RUPTURED INTO THE BILIARY TRACT: SERIES OF 52 CASES
Authors:   Digestive Surgical Department B, Ibn Sina University Hospital. Rabat, Morocco., Moufid Abdellah ,   Faculty of Medicine and Pharmacy. Mohammed V University in Rabat. Morocco., Rahal Mssrouri ,   Digestive Surgical Department B, Ibn Sina University Hospital. Rabat, Morocco.,   Faculty of Medicine and Pharmacy. Mohammed V University in Rabat. Morocco., Jalil Mdaghri ,   Digestive Surgical Department B, Ibn Sina University Hospital. Rabat, Morocco.,   Faculty of Medicine and Pharmacy. Mohammed V University in Rabat. Morocco., a Khalidlahlou ,   Digestive Surgical Department B, Ibn Sina University Hospital. Rabat, Morocco.,   Faculty of Medicine and Pharmacy. Mohammed V University in Rabat. Morocco., Said Benamar ,   Digestive Surgical Department B, Ibn Sina University Hospital. Rabat, Morocco.,   Faculty of Medicine and Pharmacy. Mohammed V University in Rabat. Morocco., Abdellatif Settaf ,   Digestive Surgical Department B, Ibn Sina University Hospital. Rabat, Morocco.,   Faculty of Medicine and Pharmacy. Mohammed V University in Rabat. Morocco.
Published: May 2023

The rupture of the hydatid cyst in the bile ducts is a frequent and serious complication whose evolution of the disease which from parasitic becomes hepatobiliary and involves the vital prognosis. The aim of our work is to review the clinical and therapeutic aspects of this complication. For this, we conducted a retrospective study of operated cases of ruptured hydatid cyst in the bile ducts. Between January 2015 and December 2022, 52 cases of hydatid cyst of the liver ruptured in the bile ducts were collected in our department, these are 30 women and 22 men, with an average age of 38.6 years with extremes between 18 and 70 years old. The clinical picture was marked in the majority of cases by an association of hepatic colic (84%), jaundice (28%), febrile syndrome (13%) and episodes of cholangitis in 8% of cases. Clinical examination found hepatomegaly in 25% of cases. The fistula between the cyst and the bile ducts was incidentally discovered in 2% of cases. The contribution of radiological examinations, in particular ultrasound, is invaluable, supplemented in case of doubt by computed tomography. The treatment of the cyst consisted of conservative treatment in most patients 71.15%, pericystectomy in 23.07%. This conservative treatment was completed by suture of the cystobiliary fistula 67.30%, catheterization 3.84%, Perdomo technique 13.46%, drainage of the main bile duct in 57.69% of cases, a bipolar drainage in 2 cases and finally a case of bilio-digestive anastomosis. The surgical procedure was radical in 3 cases. There was no known recurrence or late complications (jaundice) in the patients followed regularly in 82.69% of cases, while 11.53% patients presented postoperative complications.
AN EMPIRICAL ANALYSIS OF PRICEDISCOVERY EFFICIENCY OF THE MAIZE FUTURESMARKET IN INDIA
Authors:   Rama Devi Womens University, Bhubaneswar - 751022, Odisha., Prava Samal Gouri
Published: May 2023

Purpose - The present study examines the efficacy of the maize futures market of India in forecasting future spot pricesfor April 2020-March 2022. Design/methodology/approach - In this study, Granger causality tests and the Vector Auto Regression (VAR) model are used. The initial application of the Augmented Dickey-Fuller (ADF) test was to observe the stationarity in the spot and futures price series. Findings - The findings specified that allthe variables are stationary at the point of the first difference.According to the VAR model, neither the lag value of futures nor the same spot price of maize has a substantial impact on each other. Furthermore, the Granger Causality test suggested that the futures market has an insignificant ability to predict subsequent spot prices of maize in India. Originality/value - The results of this study will be beneficial for different players namely hedgers, speculators, commodity exchanges, policymakers, researchers, etc. who have a noteworthy interest in the agricultural commoditymarkets.
POSTPARTUM UTERINE ARTERIOVENOUS MALFORMATION: A CASE REPORT
Authors:   Department of Gynecology Obstetric, Mohamed VI University Medical Center, Marrakech, Morocco., Elmahfoudi A. , Harrou K. ,   Department of Gynecology Obstetric, Mohamed VI University Medical Center, Marrakech, Morocco., Fakhir B. ,   Department of Gynecology Obstetric, Mohamed VI University Medical Center, Marrakech, Morocco., Asmouki H. ,   Department of Gynecology Obstetric, Mohamed VI University Medical Center, Marrakech, Morocco., Soumani A. ,   Department of Gynecology Obstetric, Mohamed VI University Medical Center, Marrakech, Morocco.
Published: May 2023

Uterine arteriovenous malformations can be congenital or acquired. The acquired form results from arteriovenous anomalies in which one or more uterine arteries and venous plexuses from the endometrium and/or myometrium communicate without the interposition of a vascular nest. It is composed of tortuous arteriovenous shunts, fragile and with low resistance. It is a rare but serious pathology that can threaten the patients prognosis. The therapeutic strategy is determined by the symptoms, the desire for subsequent pregnancy, the extension and the location of the malformation. The two main types of treatment are selective embolization and hysterectomy. We report a new case of postpartum arteriovenous malformation treated by hysterectomy after failure of conservative treatment by ligation of the internal iliac arteries. The anatomopathological examination of the hysterectomy specimen confirmed the diagnosis of AVM.
Understanding the women’s digital employment intentions: The role of policies and values
Authors: Wang Wei , Jiang Songyu , Li Lin
Published: May 2023

The digital economy has enforced women’s employment and provided more possibilities for promoting employment for gender equality (SGD5). In order to achieve SDG5, the study aims to explore the role of digital employment policy and digital employment value on digital employment intention based on the support alliance theory and employment behavior theory and to build a model of digital employment for gender equality. 492 women with digital work experience from China participated in the survey. The results reveal that digital employment policy (β = 0.327, p < 0.001) and digital employment value (β = 0.454, p < 0.001) predict digital employment intention. Digital employment policy plays an active role in determining digital employment value (β = 0.546, p < 0.001). At the same time, the study claims the intermediary role of digital employment value in the structural model. This study can inspire the government and relevant departments to design more scientific and diversified employment policies for women, including policy support in economic, educational, and social aspects. Furthermore, women in the digital era should actively participate in training, improve their digital skills, understand the possibilities that digitalization brings to their work and life, and adapt themselves to the development of the digital society. This study encourages women to integrate into the digital society and actively improve their values, thus achieving SDG5.
The efficiency of the combination of topical and biological therapy in the treatment of nails psoriasis: a prospective study
Authors: Ostretsova M. N. , Kasikhina E. I. , Zhukova O. V. , Al-Hawatmi A.A-H.M.
Published: May 2023

Introduction. The severity of the psoriatic process is associated with the involvement of the scalp, genitals, fold zones and nails in the process. The selection of effective therapy for psoriasis of difficult localizations is an urgent task of modern dermatology.

Aim. To evaluate the effectiveness of treatment of moderate psoriasis and nail psoriasis with an IL-17A inhibitor in combination with a combined betamethasone dipropionate + salicylic acid ointment.

Material and methods. A 12-week prospective study included data from 60 patients who were under observation at the Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology in 2020-2021. Group 1 included 30 patients who received only the biological drug IL-17 inhibitor. Group 2 included 30 patients who received an IL-17 inhibitor in combination with topical therapy with an ointment of 0.05% betamethasone dipropionate and 3% salicylic acid (Rederm). The ointment was applied twice a day in two courses of 3 weeks with a break of 6 weeks between courses. When comparing indicators between groups, Student’s t-test was used for normal samples and the Mann- Whitney test for non- Gaussian samples.

Results. When comparing PASI and NAPSI in patients of group 2 who received an IL-17 inhibitor in combination with external therapy with an ointment of 0.05% betamethasone dipropionate and 3% salicylic acid 2 times a day for two courses of 3 weeks with a break of 6 weeks between courses, the index values statistically significantly decreased after 12 weeks of therapy (p = 0.003) compared to group 1 (p = 0.015).

Conclusions. The study showed that patients who received an IL-17 inhibitor in combination with a combined betamethasone dipropionate + salicycylic acid ointment achieved a significantly greater effect compared to patients who received only biologics. In addition, the combination with Rederm ointment has shown greater efficacy in the treatment of psoriatic onychodystrophy, which is difficult to treat even with biologics.
Chemical Characterization of Aspartic Protease from Artichoke Flower (Cynara cardunculus L. var scolymus) Using MIR Spectroscopy and Analytical Measurements
Authors: de Jesus Josane , Reis Lucas , Santos Mateus , Santos Leandro , Ferrão Sibelli
Published: May 2023

Vegetable proteases have been studied as milk coagulants, and artichoke flower (Cynara cardunculus L. var scolymus) has potential coagulant action as a substitute for microbial chymosin. The objective was to perform chemical characterization of aspartic proteases from artichoke flower (Cynara cardunculus L. var scolymus) by mid-infrared spectroscopy (MIR) and analytical measurements. Artichoke flower extracts were obtained and crude thistle flower extract and microbial chymosin were used as a reference. Plant extracts and microbial chymosin were analyzed for protein concentration, proteolytic activity (PA), milk clotting activity (MCA), specificity ratio (SR), effects of pH, temperature, NaCl and CaCl2 concentration on MCA and PA and characterized by electrophoretic, spectroscopic, chromatographic and storage stability. The results indicated that the crude extract of artichoke flower showed high MCA (510.08 SU mL-1 ), low PA (10.50 µg mg-1), SR (48.57) and storage stability for up to 90 days under frozen. The electrophoretic profile of artichoke flower resulted in a protein band with an apparent molecular weight of 32 kDa, associated with cardosin A. Artichoke flower may be a new alternative for commercial plant proteases with active enzymes for milk coagulation.
Techno-economic analysis of a hybrid electrodialysis–batch reverse osmosis process for brackish water desalination
Authors: Ankoliya Dipak , Mudgal Anurag , Sinha Manish Kumar , Patel Vivek , Patel Jatin
Published: May 2023

Hybridization of electrodialysis (ED) and batch reverse osmosis (BRO) process is used to reduce the brine volume and water production cost. The ED process has the benefit of high water volume recovery in brackish water desalination, while reverse osmosis can produce pure water at a low production cost. Here, a simple hybrid process layout is preferred in which the ED process is kept in the reject stream of the BRO process and permeate from both ED and BRO is mixed. Recovery of the ED process is kept at 70% which can decide the blending ratio of ED and BRO permeates. The capital cost and operating cost of ED and BRO processes are used to calculate water production cost. The water production cost from the hybrid ED–BRO process is found to be 0.22 $ m−3 of freshwater when the feed concentration is 1,100 ppm. The cost increases from 0.20 to 0.34 $ m−3 with feed concentration from 1,000 to 2,000 ppm. In the cost, a major portion comes from the capital equipment in which the highest contributor is the membrane for both ED and BRO processes.
Impact of bioretention cells in cities with a cold climate: modeling snow management based on a case study
Authors: Gougeon Garance , Bouattour Ons , Formankova Emma , St-Laurent Julien , Doucet Samuel , Dorner Sarah , Lacroix Sandrine , Kuller Martijn , Dagenais Danielle , Bichai Françoise
Published: May 2023

The performance of blue-green infrastructures (BGIs) has been well documented in temperate and subtropical climates, but evidence supporting their application in cold climates, especially during snowmelt, is still scarce. To address this gap, the present study proposes a modeling method for simulating the performance of bioretention cells during snowmelt according to different spatial implementation scenarios. We used the Storm Water Management Model (SWMM) of a catchment in a medium-sized city in Quebec, Canada as a case study. Pollutants commonly found in the snow (TSS, Cr, Pb, Zn, Cl–) were included in the model using event mean concentrations (EMCs) documented in the literature. Bioretention cells performed best on industrial road sites for the entire snowmelt period. Bioretention cell performance was affected by snow management procedures applied to the roads in residential areas. Not modeling the snow cover build-up and meltdown in the simulation led to higher runoff and bioretention cell performance. Modeling results facilitated the identification of bioretention cell sites that efficiently controlled runoff during snowmelt. Such information is needed to support decision planning for BGIs in cities with cold climate.
Hydrologic regionalization of non-stationary intensity–duration–frequency relationships for Indian mainland
Authors: Mohan Meera G , AR Akhilesh , S Adarsh , S Badarinadh , Krishnan Ajeesh , Rajan Anand
Published: May 2023

Intensity–duration–frequency (IDF) curve is one of the important hydrologic tools used for the design of hydraulic infrastructure. The static return period assumption of precipitation extremes is invalid in a changing climate environment, and the underestimation of rainfall intensity may lead to the failure of infrastructure in extreme events. This study first developed the non-stationary (NS) IDF curves for six selected locations in India based on sub-daily station data based on time-dependent estimates of five combinations of Generalized Extreme Value (GEV) distribution parameters. Then, in order to identify the critical regions of rainfall non-stationarity, the IDF curves were developed for 357 grid points over India using the daily gridded data for the period 1951–2016 at 1° × 1° resolution. The comparison of spatial patterns of rainfall intensity estimates under stationary and non-stationary showed that about 23% of grids showed an overestimation of NS rainfall over their stationary counterparts by at least 15%. About 32 grid locations which showed at least 15% overestimation of rainfall under an NS case displayed a significantly increasing rainfall trend. The majority of the grids with larger deviation of non-stationary rainfall estimates over stationary values are located in India's eastern regions and coastal belts.