bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Earning Per Share (EPS), Return On Equity (ROE), Dan Net Profit Margin (NPM) Terhadap Harga Saham
Authors: Zalukhu Rika Surianto , Hutauruk Rapat Piter Sony , Colyn Daniel , Sudarjah Gugum Mukdas
Published: August 2024

The purpose of this study is to analyze the effect of earnings per share (EPS), return on equity (ROE), and net profit margin (NPM) on stock prices. The dependent variable of the study is the stock price while the independent variables of the study are EPS, ROE and NPM. The study was conducted on LQ45 index companies listed on the Indonesia Stock Exchange (IDX) for the period from August 2018 to January 2019. The study population consisted of 45 companies, and the sampling technique used was saturated sampling. This study uses secondary data. The data was analyzed using multiple linear regression analysis methods. The results of the analysis show that earnings per share and return on equity have a partially positive and significant effect on stock prices. While Net Profit Margin has a negative and insignificant effect on stock prices. Earning per share, return on equity and net profit margin simultaneously have a significant effect on stock prices.
Analisis Peramalan Nilai Ethereum Menggunakan Model Autoregressive Integrated Moving Average
Authors: Liunardo Nycholas , Gunawan Didik , Murniati Neni
Published: August 2024

The purpose of this study is to test the ability of the Autoregressive Integrated Moving Average (ARIMA) model to predict the Ethereum value which fluctuates greatly due to the Rusian and Ukraine War. The population in this study is daily closing price data for the period May 2021 to May 2022, so the sample in this study is 396 data time series data. The results showed that the best ARIMA model for predicting the Ethereum value was ARIMA (1,1,0). ARIMA (1,1,0) can predict the Ethereum value pretty good because the value of the forecasting results is not much different from the actual value. This is also evidenced by the results of the accuracy test using MAPE which has a result of 0,448 which means the accuracy of forecasting is 55,2%.
PENGUATAN MANAJEMEN USAHA DAN STRATEGI PEMASARAN UMKM DI DESA SEI SUKA DERAS KECAMATAN SEI SUKA KABUPATEN BATU BARA
Authors: Syafrizal Rodi , Nainggolan Benhard
Published: August 2024

Usaha Mikro Kecil Menengah di desa Sei Suka Deras memiliki banyak potensi untuk memperoleh tingkat keuntungan yang cukup tinggi. Namun, disayangkan kebanyakan masyarakat di sana masih belum mengetahui potensi akan desa tersebut. Tujuan dari kegiatan ini adalah untuk  menggali potensi –potensi usaha yang ada. Terlebih, saat ini perkembangan teknologi yang semakin pesat dimana akan semakin mempermudah menjalankan suatu usaha. Metode yang dilakukan dalam kegiatan pengabdian ini adalah dengan cara Pengamatan, observasi serta wawancara kepada para pelaku UMKM. Hasilnya para pelaku bisnis memahami mekanisme strategi pemasaran dengan lebih baik, dan mereka menggunakan media elektronik untuk mempromosikan produk dan layanan mereka untuk meningkatkan penjualan.
STIE Bina Karya Students’ Financial Literacy
Authors: Haratika Haya , Purba Anita , Suryaman Restu A
Published: August 2024

Financial litarcy is essential to be implemented seriously in individual life. The good financial management will lead someone into prosperity and the poor financial management will lead into financial collapse. Education background affects someone’s ability in managing their expenses. The higher education, the better understanding on financial literacy . The purpose of this study was to gain the information from the 8th semester college students year 2023 STIE Bina Karya about their financial litearcy. This study implemented qualitative method which took 36 informants who represent each class. The researcher distributed open-ended questions through online based questionaire to obtain the data. The data then analyzed by utilyzing thematic analysis. The findings of this study were STIE Bina Karya the 8th semester students knew well about financial literacy, they have implemented the four parts of financial literacy those were: personal financial management, bank deposits, insurance, and stock investment. The implication of this research findings was to enhance the number of college students’ understanding of financial literacy and to inform the benefits after implementing the correct financial literacy.
Pengembangan Umkm Dan Pengelolahan Bank Sampah Sebagai Industri Kreatif Melalui Kuliah Kerja Nyata Dikelurahan Tanjung Marulak
Authors: Arseto Dedi Dwi , Siregar Aisyah , Sianipar Christin
Published: August 2024

Keberadaan Bank Sampah sangat membantu dalam mengurangi volume sampah dan dapat menunjang kehidupan ekonomi serta sosial masyarakat sekitar. Namun beberapa kendala muncul seiring berjalannya waktu. Sehingga eksistensi Bank Sampah ini mulai terancam. Beberapa persoalan muncul disebabkan antara lain karena kurangnya kesadaran dan motivasi, pengetahuan dalam pemilahan sampah, pengelolaan yang kurang efektif serta masih minimnya pengembangan dan pemanfaatan hasil Bank Sampah yang bisa dirasakan oleh masyarakat. Tujuan Pengabdian Kepada Masyarakat ini adalah untuk meningkatkan peran serta masyarakat dalam kegiatan Bank Sampah dan meningkatkan manfaat dari Bank Sampah. Sehingga Bank Sampah mempunyai daya tarik dan dapat memotivasi warga untuk lebih aktif dalam kegiatan Bank Sampah. Wujud dari program pengabdian ini adalah mengubah sampah menjadi kerajinan tangan dan menjaga kebersihan lingkungan dari sampah plastik sekaligus bisa dimanfaatkan kembali reuse menjaga kebersihan lingkungan dari sampah plastik sekaligus
Pengaruh Kualitas Produk, Harga Dan Citra Merek Terhadap Keputusan Pembelian Melalui Kepercayaan Pada Kosmetik Ms Glow Di Kota Tebing Tinggi
Authors: Lukieto Cahyadi  , Khoirotun Nisa Br. Purba
Published: August 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kualitas produk, harga dan citra merek terhadap keputusan pembelian melalui kepercayaan pada kosmetik MS Glow diKota Tebing Tinggi. Metode penelitian yang digunakan adalah metode kuantitatif dengan menggunakan bantuan SPSS versi 25.00.yang dikumpulkan dari hasil penyebaran kuisioner kepada pengguna MS Glow Kota Tebing Tinggi sebanyak 96 responden. Metode analisis yang digunakan dalam penelitian ini yaitu menggunakan uji instrumen yaitu uji validitas dan reliabilitas. Uji asumsi klasik yaitu uji normalitas , uji multikolonearitas, uji heteroskedasitas, analisis regresi linier berganda, analisis koefisien determinasi (R2), uji hipotesis yaitu uji T dan analisis jalur (Path analysis). Hasil dari SPSS dalam penelitian ini yaitu variabel Kualitas Produk (X1) tidak berpengaruh terhadap variabel Kepercayaan (Z), variabel Harga (X2) berpengaruh terhadap variabel Kepercayaan (Z),  variabel Citra Merek (X3) tidak berpengaruh terhadap variabel Kepercayaan (Z),Variabel variabel Kualitas Produk (X1) tidak berpengaruh terhadap keputusan pembelian (Y), Variabel Harga (X2) tidak berpengaruh terhadap keputusan pembelian (Y), Variabel Citra Merek (X3) berpengaruh terhadap keputusan pembelian (Y), variabel Kepercayaan (Z) berpengaruh terhadap keputusan pembelian (Y) dan analisis jalur memperlihatkan Kualitas Produk (X1) tidak berpengaruh terhadap keputusan pembelian (Y) melalui Kepercayaan (Z), Harga (X2) berpengaruh terhadap keputusan pembelian (Y) melalui Kepercayaan (Z) dan Citra Merek (X3) berpengaruh terhadap keputusan pembelian (Y) melalui Kepercayaan (Z).
Peran Kebijakan Dividen Dalam Memediasi Harga Saham Perusahaan Sub Sektor Asuransi
Authors: Yuni Andri Ekawati  , Nursaimatussaddiya  , Lianarti Purba
Published: August 2024

Tujuan dilakukan penelitian ini yaitu untuk melihat pengaruh Return On Assets dan Earning Per Share dan Kebijakan dividen yang yang diproksikan Dividend Payout Ratio terhadap harga saham dalam perusahaan asuransi yang termasuk pada Bursa Efek Indonesia. Pengaruh yang ingin diketahui yaitu pengaruh langsung imaupun itidak ilangsung. iJenis ipenelitian iini iadalah iexsplanatory iresearch yang imenjelaskan ihubungan ikausal iantara ivariabel-variabel imelalui ipengujian ihipotesis. Penelitian iini imenggunakan isampel isebanyak i8 iperusahaan. iPengambilan isampel menggunakan teknik ipurposive isampling. iAlat iuji iyang idigunakan iyaitu isoftware ismart ipls i3.0. iDari ihasil pengujian ipengaruh ilangsung iini idapat idisimpulkan ibahwa iReturn iOn iAssets, iEarning iPer Share idan iKebijakan idividen itidak imemiliki ipengaruh iterhadap iHarga iSaham. iReturn OniAssets imemiliki ipengaruh iterhadap ikebijakan idividen isedangkan iEarning iPer iShare itidak memiliki ipengaruh iterhadap ikebijakan idividen. iHasil ipengujian itidak ilangsung ijuga menunjukkan ibahwa iReturn iOn iAssets idan iEarning iPer iShare itidak imemiliki ipengaruh itidak langsung iterhadap iharga isaham yang dimediasi oleh kebijakan dividen.
Analisis Pengaruh Kualitas Pelayan Dan Promosi Terhadap Loyalitas Nasabah Melalui Kepuasan Nasabah Sebagai Variabel Intervening
Authors: Lubis Nanda Sri Dewi , Gunawan Didik
Published: August 2024

This study aims to find out more clearly how the Analysis of Service Quality and Promotion of Customer Loyalty through Customer Satisfaction as an Intervening variable (Case Study of PT Pegadaian Tebing Tinggi Branch Office). This study uses quantitative methods. This type of research is explanatory research which explains the causal relationship between variables and hypothesis testing. The sample used in this study amounted to 100 respondents with the accidental sampling method with the characteristics of customers who have made purchases and used the services of PT Pegadaian Tebing Tinggi Branch. Data analysis in this study used Validity Test, Reliability Test, Hypothesis Testing (t test). The data processing program in this study uses a software program Smart PLS version 3.0. The results of the study indicate that Service Quality has an effect on Customer Satisfaction of PT. Pegadaian Tebing Tinggi Branch. Promotion has an effect on Customer Satisfaction of PT. Pegadaian Tebing Tinggi Branch. Service Quality has no effect on Customer Loyalty of PT. Pegadaian Tebing Tinggi Branch. Promotion has no effect on Customer Loyalty of PT. Pegadaian Tebing Tinggi Branch. Customer Satisfaction has no effect on Customer Loyalty of PT. Pegadaian Tebing Tinggi Branch. Service quality has no effect on Customer Loyalty through customer satisfaction as an intervening variable on the product of PT Pegadaian Branch Tebing Tinggi. Promotion has no effect on Customer Loyalty through Customer Satisfaction as an intervening variable on the product of PT Pegadaian Branch Tebing Tinggi
Pengaruh Motivasi dan Komitmen Organisasi Terhadap Kepuasan Kerja Pada Karyawan Cafe Kopi Dolok Jl. Jenderal Sudirman Kota Tebing Tinggi
Authors: Nainggolan Benhart
Published: August 2024

This study aims to determine how the influence of motivation and Organizational Commitment on Job Satisfaction of   employees of Cafe Kopi Dolok Jl.  Jenderal Sudirman Tebing Tinggi City. Based on the results of observations made by researchers, it is known that there are several problems regarding job satisfaction at the Cafe Kopi Dolok, including motivation and organizational commitment. The research sample used as many as 31 people with saturated sampling method. This research uses a type of quantitative research with nature of replication research. This research is a replication of previous research where the difference lies only in the object studied. The research method uses multiple linear regression analysis. The results of the hypothesis test state that: Hypothesis 1 is accepted, then motivation has an  affects on  job satisfaction. Hypothesis 2 is accepted, so  organizational commitment affects job satisfaction  . Hypothesis 3 is accepted, then the variables of motivation and organizational commitment  simultaneously affect the job satisfation of employees  Cafe Kopi Dolok Jl. Jenderal Sudirman  Tebing Tinggi City.
Peningkatan Kapasitas Aparat Desa dalam Pemetaan Kawasan Potensi dan Sumberdaya Perdesaan
Authors: Samsuar Samsuar , Useng Daniel , Sapsal Muhammad Tahir , Ali Hikmah
Published: August 2024

Tujuan Kegiatan ini adalah untuk memperkenalkan dan memberikan pengetahuan serta keterampilan kepada aparat perdesaan tentang pentingnya pemetaan potensidesa yang akan dijadikan rujukan dan basis data dalam perencanaan dan pengelolaan pengembangan wilayah perdesaan di masa yang akan datang. Target khusus yang ingin dicapai adalah sistem kendali yang ditawarkan ini, akan memberikan pengendalian yang lebih teliti dan tepat adanya peningkatan kapasitas aparat desa dlam memetakan potendi yang ada di desanya masing masing yang dapat diakses dengan cepat oleh para pengambil keputusan yang ada dalam perencanaan pengembangan wilayah berbasis peta peta digital. Metode yang digunakan dalam kegiatan ini terdiri dari beberapa tahapan. Tahap (1) Identifikasi kemampuan dasar, pemetaan dari aparat desa, (2) penyiapan perangkat penunjang pelatihan aparat desa, (3) demonstrasi dan pendampingan pemetaan potensi sumberdaya desa, (4) pada tahap akhir kegiatan, dilakukan evaluasi untuk mengetahui tingkat keberhasilan kegiatan. Kegiatan dilaksanakan pada satu kecamatan di Kabupaten Sinjai yakni Kecamatan Sinjai Barat yang terdiri atas 8 Desa.
Optimalisasi Pemanfaatan Lahan Pekarangan Untuk Menumbuhkan Ketahanan Pangan Rumah Tangga Dimasa Pandemi Covid-19
Authors: Maulidiyah Rafiqah , Iqbal
Published: August 2024

Covid-19 is a disease caused by the acute respiratory syndrome corona virus 2 (SARS-CoV-2) and can be transmitted from one human to another through coughing / sneezing (droplets), not through the air. As a result of the Covid-19 pandemic, various policies were implemented to break the chain of the spread of the Covid-19 virus in Indonesia, one of which was the implementation of physical distancing. This has an impact on one of the sectors in Indonesia, namely the agricultural sector in terms of fulfilling community food. Efforts to foster household food security can be made by optimizing the use of yard land as a source of food. This community service activity aims to invite the people of Banyorang Village to optimize the use of their yards as a source of food. This activity was carried out by using the method of making a demonstration plot for farm yards and recording a video of the activity which was then published on YouTube so that it could be watched by the community, especially the people of Banyorang Village. The result of this activity is to raise public awareness in utilizing yard land and obtaining food from the yard. This activity is carried out from home so that in addition to meeting food needs, it can also minimize the spread of covid-19.
Edukasi Pemanfaatan Limbah Botol Plastik Sebagai Media Tanam Di Lahan Sempit Dan Pembagian Benih Kepada Masyarakat Di Kelurahan Kadidi
Authors: Febriana Febi , Azis Abdul
Published: August 2024

Budidaya tanaman sayur di era moderen ini dapat menjadi salah satu kegiatan untuk mengisi waktuluang dengan hal positif di tengah pandemic covid-19. Salah satu upaya yang dapat kita lakukandengan penanaman sayur atau buah dengan menggunakan media barang bekas atau bisa dikatakanplastik bekas untuk wadah media tanam, hal in tidak hanya kita memiliki kebun sayur sendiri tanpalahan tanah yang luas namun juga dapat menjadu upaya pengurangan sampah plastik. Denganpengenalan, pelatihan, dan pendampingan untuk mengetahui bagaimana cara penanman sayur yangefektif dengan media barang bekas atau sampah plastik. Dari hasil penelitian, metode tersebut sangatrelevan dan cocok diguanakan untuk meningkatkan upaya pengurangan sampah plastik dan jugamenjadi kegiata yang positif bagi masyarakat ditengah pandemic covid-19 ini.
Penyuluhan Pertanian Organik dan pembuatan pupuk organik cair Di Desa Bola Bulo, Kecamatan Pitu Riase, Kabupaten Sidenreng Rappang
Authors: Ramadani Putri , Azis Abdul
Published: August 2024

Kuliah Kerja Nyata (KKN) merupakan suatu kegiatan yang memberikan kesempatan kepada mahasiswa untuk bisa berdampingan baik dengan masyarakat. Peran mahasiswa sebagai Social Control yaitu mahasiswa diharapkan mampu menjadi pengontrol sebuah kehidupan sosial pada masyarakat dengan cara memberikan saran, kritik serta solusi untuk permahsalahan sosial masyarakat maupun permasalahan bangsa. KKN yang diselenggarakan perguruan tinggi menyebarkan mahasiswa ke beberapa desa maupun wilayah yang masih perlu dikembangkan. Namun, berbeda dengan tahun ini, pandemi Covid-19 yang melanda berbagai negara termasuk Indonesia, menyebabakan terjadinya perubahan sistem pembelajaran. Tak terkecuali pada pelasnaan program KKN oleh mahasiswa. Universitas Hasanuddin dengan cepat melakukan penyesuaian , dimana pada Kuliah Kerja Nyata (KKN) mahasiswa kali ini pihak universitas mengusung tema KKN Tematik yakni “Peningkatan Peran Mahasiswa KKN Unhas dalam Mewujudkan Masyarakat Sehat Ekonomi Bangkit di Masa Pandemi Covid-19 Tahun 2021” Gel.106 Universitas Hasanuddin, dengan tema tersebut setiap mahasiwa bebas untuk memilih program kerja, baik yang sesuai dengan bidang ilmu yang dimiliki maupun diluar dari bidang keilmuannya. Program pengabdian melalui KKN Tematik ini dilaksanakan menggunakan metode pengabdian secara during dan luring. Program KKN dilaksanakan di Desa Bola Bulu, Kecamatan Pitu Riase, Kabupaten Sidenreng Rappang. Program kerja menghasilkan beberapa luara diantaranya masyarakat dapat mengetahui budidaya pertanian organik dan cara pembuatan pupuk oganik cair dengan memanfaatkan limbah sayuran rumah tangga dan bahan-bahan yang ada di sekitar lingkungan masyarakat.
Edukasi Pemanfaatan Nasi Basi Sebagai Pupuk Organik Cair Dan Aplikasinya Untuk Pemupukan Tanaman Di Kelurahan Campaga, Kecamatan Tompobulu, Kabupaten Bantaeng
Authors: Amanah Nurhalizah , Azis Abdul
Published: August 2024

Dapat dipastikan di setiap harinya ada nasi yang tersisa dan tidak dapat untuk dikonsumsi lagi. Nasi basi yang dibuang begitu saja di tempat sampah tanpa ada pengolahan lanjutan hingga lambat laun memberikan efek bau yang kurang sedap pada lingkungan dan dapat menjadi tempat hidup mikroorganisme-mikroorganisme yang tidak diharapkan. Terdapat salah satu upaya yang dapat dilakukan untuk meminimalisir limbah nasi basi ini adalah yakni dengan mengolah limbah nasi basi tersebut menjadi pupuk organik cair. Tujuan dari pelaksanaan program kerja ini adalah memberikan edukasi kepada masyarakat mengenai cara pengolahan limbah nasi basi menjadi pupuk organik cair yang dapat bermanfaat dalam mengoptimalkan pertumbuhan tanaman yang dibudidayakan sekaligus mengurangi limbah nasi basi dan limbah pertanian yang dapat mencemari lingkungan. Adapun metode yang digunakan dalam pelaksanaan program kerja pengabdian yaitu melakukan identifikasi masalah melalui survei pelaksanaan KKN dan observasi langsung di rumah warga, mencari dan mengumpulkan materi untuk bahan brosur POC yang akan dibuat, mengumpulkan alat dan bahan pembuatan POC dan yang terakhir mengupload brosur edukasi ke media sosial dan melakukan edukasi langsung kepada masyarakat melalui pembagian brosur. Dan juga diadakan pembagian hasil dari POC nasi basi kepada masyarakat. Pelaksanaan program kerja dilakukan di Kelurahan Campaga, Kecamatan Tompobulu, Kabupaten Bantaeng, Sulawesi Selatan. Melalui edukasi pemanfaatan limbah nasi basi menjadi pupuk organik cair dapat meningkatkan kreativitas masyarakat dalam pembuatan pupuk organik cair yang dapat bermanfaat pada pertumbuhan tanaman.
PENERAPAN PAKET TEKNOLOGI TEPAT GUNA DAN PEMANFAATAN LIMBAH UNTUK DIVERSIFIKASI PRODUK OLAHAN KELAPA
Authors: Parhusip Bastian
Published: August 2024

Kelapa mempunyai daya guna yang luas karena selain sebagai bahan baku industri pangan dan non pangan juga sebagai konsumsi rumah tangga. Pendayagunaan kelapa tidak hanya sebagai minyak goreng tetapi ada beberapa produk olahan kelapa lain yang menjadi mata dagang dipasar internasional antara lain, kelapa parut, santan segar, arang tempurung, gula kelapa dan minyak kelapa murni atau yang dikenal dengan sebutan Virgin Coconut Oil (VCO). Desa Pondos berada di wilayah Kecamatan Amurang Barat, Kabupaten Minahasa Selatan, Sulawesi Utara. Daerah ini memiliki hasil perkebunan kelapa yang mencapai 20.000 butir/bulan. Melalui Badan usaha milik desa, pemerintah desa Pondos membentuk IKM yang diberi nama Mapalus. IKM ini memiliki beberapa permasalahan diantaranya 1) Pengupasan kelapa masih manual menggunakan tangan, jumlah kelapa yang dikupas setiap harinya berkisar antara 400-600 butir kelapa (12 jam pengerjaan), 2) pemerasan santan masih manual menggunakan tangan, 3) santan yang dihasilkan tidak homogen sehingga kualitas rendah, 4) produk belum ada uji laboratorium tentang komposisi kimia minyak kelapa, 5) hasil limbah kelapa tidak dimanfaatkan, 6) belum adanya diverisifikasi produk olahan kelapa.
Berdasarkan hasil Kegiatan PKM yang diadakan oleh tim, untuk meningkatkan produktifitas, kualitas pengolahan kelapa dan pengolahan produk limbah kelapa, terdapat beberapa kegiatan yang dialakukan diantaranya: 1) tersedianya Mesin Pengupas kelapa yang bisa menghasilkan minimal 9600 buah kelapa dalam 8 jam kerja setiap harinya, 2) Terdapat peralatan pemeras santan sehingga memudahkan proses pembuatan olahan minyak kelapa; 3) Adanya alat sentrifugasiuntuk menghomogenkan santan dan memudahkan pemisahan krim dan skim; 4) Pengujian laboratorium terhadap komposisi kimia minyak kelapa; 5) pemberian pelatihan manajemen pemasaran. Hasil kegiatan ini meningkatkan produktifitas dan perekonomian masyarakat terkhusus IKM Mapalus Pondos
Rajawali (Ragam Jejak Warisan Budaya Dan Kearifan Lokal): Pengembangan Desa Wisata Berkelanjutan Berbasis Budaya Dan Produk Lokal Di Desa Sanrobone, Kabupaten Takalar
Authors: Khovifah Basri Aisyah Nur , Fahmi Alfarabi  , Andi Halil Alamsyah Ys  , Muhammad Hasyim  , Nurul Aliyah Akhmad  , Engki Fatiawan  , Dedi  , Sadir Riadi  , Multi Altazani  , Rahmawati Agmus  , Mutmainnah  , Maha Rani Abdullah  , Rially Riall Rabid  , Dhea Anugrah  , Husnul Mubarak
Published: August 2024

Pada abad ke-15 M, di Desa Sanrobone, Kabupaten Takalar, terdapat kerajaan dengan nama yang sama. Namun, perubahan sosial dan ekonomi membuat kondisi masyarakat tidak sebaik sebelumnya. Situs-situs penting seperti rumah adat Balla Lompoa, makam leluhur, dan masjid tua usang dimakan waktu. Sektor pertanian dan kelautan menjadi mata pencaharian utama, tetapi juga terdapat pengembangan UMKM. Artikel ini memberikan wawasan dan panduan bagi pengembangan desa wisata budaya di daerah lain dengan potensi budaya dan kearifan lokal yang kaya. Pendekatan pemberdayaan masyarakat menggunakan tujuh dimensi (7D) dan melibatkan survei, pelatihan, pendampingan, monitoring, dan evaluasi. Peneliti berinteraksi dengan Kepala Desa dan aparat desa, serta menggunakan literatur pendukung seperti jurnal, artikel, dan video. Tindakan disesuaikan dengan kebutuhan masyarakat yang diidentifikasi dalam survei, termasuk pelatihan UMKM, publikasi, dan pengelolaan desa wisata. Evaluasi dilakukan untuk menganalisis hasil dan tingkat antusiasme masyarakat. Pengembangan desa wisata budaya di Desa Sanrobone menghasilkan perubahan signifikan. Masyarakat mitra terampil mengelola UMKM, pemuda mahir dalam pengambilan gambar situs budaya, dan kelompok sadar wisata aktif dalam pengelolaan situs budaya serta pembuatan papan informasi. Kesadaran dan pengetahuan masyarakat tentang potensi wisata budaya meningkat, dengan rasa tanggung jawab bersama menjaga situs-situs tersebut.
PENGARUH METODE PENGERINGAN TERHADAP KADAR VITAMIN C DAN AKTIVITAS ANTIOKSIDAN DAUN KELOR (Moringa oleifera)
Authors: Paramita Vilia Darma
Published: August 2024

Daun kelor kaya akan nutrisi karena mengandung protein, karbohidrat, lemak, serat, vitamin, dan mineral karenanya banyak digunakan sebagai makanan dan obat. Penelitian ini bertujuan untuk mengetahui pengaruh berbagai metode pengeringan terhadap kadar vitamin C dan aktivitas antioksidan daun kelor. Penelitian ini membandingkan kadar vitamin C dan aktivitas antioksidan dari daun kelor yang dikeringkan dengan metode pengeringan matahari, dalam ruangan dan oven suhu 40, 50 dan 60oC. Hasil penelitian menunjukkan pengeringan terbaik menggunakan oven suhu 40oC dan matahari dengan kadar vitamin C masing-masing 15,82 dan 15,04 mg/100 g bahan. Secara umum berbagai metode pengeringan tidak mempengaruhi aktivitas antioksidan yang ditunjukkan dengan nilai IC50 yang tergolong antioksidan kuat, tetapi untuk perlakuan dengan suhu tinggi (50 dan 60oC) terdapat sedikit pengurunan nilai IC50 dari nilai IC50 daun segar, hal ini mungkin disebabkan karena produksi produk reaksi Maillard (MRPs) yang bersifat antioksidan.  Penelitian menunjukkan metode pengeringan dengan oven pada suhu 40°C memberikan hasil terbaik.
Food Bar Formulation Based on Local Soy Tempe Flour and Kepok Banana Flour
Authors: Zesita devy 99 Bemy cornellia
Published: August 2024

Food bar adalah jenis makanan dengan kalori tinggi dan dihasilkan dari bermacam bahan atau biasa disebut blended food, bersifat kaya akan nutrisi, dan berbentuk padat serta kompak. Food bar umumnya mengandung protein, karbohidrat dan serat yang tinggi. Sebagai salah satu aplikasi program diversifikasi pangan, perlu dikembangkan pembuatan food bar dari bahan-bahan lokal seperti tempe kedelai dan pisang kepok. Penelitian ini bertujuan untuk mengetahui perbedaan karakteristik kimia dan sensori food bar dengan perbedaan formulasi tepung tempe kedelai dan tepung pisang kepok, serta mendapatkan formulasi yang menghasilkan karakteristik kimia dan sensori terbaik. Rancangan penelitianyang digunakan adalah Rancang Acak Kelompok (RAK) dengan satu faktor (p) yaitu formulasi tepung tempe kedelai dan tepung pisang kepok (p) yang terdiri dari 5 taraf dan 5 kali ulangan. Hasil penelitian menunjukkan bahwa formulasi tepung tempe dan tepung pisang kepok mempengaruhi kadar air, kadar abu, kadar lemak dan kadar protein, namun tidak mempengaruhi kadar serat kasar food bar yang dihasilkan. Formula yang menghasilkan karakteristik kimia dan sensori terbaik adalah formulasi tepung tempe dan tepung pisang kepok (45:55) dengan kadar air 12,66%, kadar abu 2,44%, kadar lemak 31,64%, kadar protein
 
18,90%, kadar karbohidrat 34,35%, kadar serat kasar 0,97%, penilaian warna 2,93 (kurang suka – sangat suka), rasa 3,38 (suka – sangat suka), aroma 2,70 (kurang suka – sangat suka), tekstur 3,30 (suka – sangat suka), dan kesukaan keseluruhan 3,22 (suka – sangat suka).
Kata Kunci : Protein, Serat, Tepung Tempe Kedelai, Tepung Pisang Kepok, Tapioka, Food Bar.
KOMPARASI NILAI INDEKS FAKTOR PANJANG DAN KEMIRINGAN LERENG PADA BEBERAPA DATA DIGITAL ELEVATION MODEL RESOLUSI MENENGAH
Authors: Faisol Arif , Mashudi Mashudi , Bachri Samsul
Published: August 2024

Faktor panjang dan kemiringan lereng (LS) merupakan parameter utama pada sejumlah model prediksi erosi. Sejumlah peneliti didunia telah mengembangkan algoritma untuk menganalisis LS berdasarkan data Digital Elevation Model (DEM). Penelitian ini bertujuan untuk membandingkan nilai LS pada 2 (dua) Daerah Aliran Sungai (DAS) di Kabupaten Manokwari Provinsi Papua Barat berdasarkan analisis beberapa data DEM resolusi menengah, yaitu DEM Space Shuttle Radar Topography Mission (SRTM), ASTER Global DEM, Jaxa’s Global ALOS 3D World, dan Copernicus DEM. Nilai LS dihitung menggunakan metode Desmet – Govers. Hasil penelitian menunjukkan LS yang dianalisis menggunakan DEM Copernicus memberikan nilai yang lebih tinggi dibandingkan LS yang dihasilkan dari DEM SRTM, ASTER Global DEM, dan Jaxa’s Global ALOS 3D World, sedangkan LS yang dihasilkan dari data ASTER Global DEM memberikan nilai lebih rendah. Berdasarkan uji F dan uji korelasi pearson, LS hasil analisis metode Desmet – Govers dan DEM SRTM, ASTER Global DEM, Jaxa’s Global ALOS 3D World, dan Copernicus DEM  memiliki perbedaan yang signifikan dengan tingkat korelasi lemah hingga sedang
Morphometric Analysis of Karangan Watershed East Kutai Regency, Using Remote Sensing Data and GIS Techniques
Authors: Suryanto Joko , Amprin Amrpin , Krisbiyantoro Joko , Anisum Anisum
Published: August 2024

Pengelolaan Daerah Aliran Sungai (DAS) membutuhkan informasi karakteristik DAS yaitu parameter morfometri DAS. Teknik Geographic Information System (GIS) dan pemanfaatan data penginderaan jauh berupa data Digital Elevation Model (DEM) dapat digunakan dalam menganalisis parameter morfometri DAS. Penelitian ini bertujuan untuk memperoleh parameter morfometri DAS berupa aspek linier, areal, dan aspek relief DAS Karangan. Penelitian menggunakan data DEM Shuttle Radar Topography Mission (SRTM) dan teknik GIS untuk memperoleh parameter morfometri DAS. Hasil analisis jaringan aliran yang diperoleh dari ekstraksi data DEM SRTM diperoleh bahwa DAS Karangan mempunyai orde sungai sebanyak 7 dengan kerapatan aliran sangat rendah dan tekstur aliran yang halus. Parameter kerapatan aliran, tekstur aliran, jumlah infiltrasi, dan konstanta pemeliharaan sungai menunjukkan bahwa DAS Karangan mempunyai kapasitas infiltrasi yang tinggi dan aliran permukaan yang sedikit sehingga DAS tidak rentan terhadap bahaya erosi. Parameter rasio percabangan sungai rendah dan rasio elongasi yang tinggi menunjukkan bahwa DAS Karangan mempunyai bentuk mendekati bulat dengan karakteristik curah hujan cepat terkonsentrasi menjadi debit aliran. Nilai Hypsometric integral menunjukkan bahwa DAS Karangan dalam fase perkembangan geomorfologi dewasa dan didominasi bentuk lahan fluvial.
The Effect of Drying Air Velocity and Grain Mass on the Drying Rate of Inpari 42 Grain in a Fluidized Bed Dryer.
Authors: Ibrahim A. Muh. Farhan Qibran , Salengke Salengke , Salim Iqbal , Hardinasinta Gemala
Published: August 2024

Statistical data shows that rice production increases every period along with the increase in demand. Harvested paddy must be dried immediately to avoid damage due to microbial attack that can live in high moisture content. Therefore, the main objective of drying is to reduce the moisture content from the harvest moisture content (23-27%) to a safe moisture content for storage (14%). Currently, there are several dryers made as a solution in post-harvest handling of grains such as green beans, soybeans, grain and so on. One example of this dryer is the Fluidized Bed Dryer. This tool is a mechanical dryer that can be used in drying grain. The advantage of this tool is that the temperature can be controlled and can produce quality and uniform drying results. The purpose of this study was to determine the drying characteristics of Inpari 42 grain using a fluidized bed dryer. This research method uses speed variations of 1.5 m/s, 2.0 m/s, and 2.5 m/s with sample masses of 200 g, 250 g and 300 g, using a temperature of 55 ℃. The research parameters include moisture content, drying rate, damaged grain. The drying process shows that the change in sample mass is influenced by the air velocity used. Along with the increase in moisture content, the drying rate will affect the rate of drying obtained in this study the drying rate pattern is decreasing. It can be concluded that air velocity affects the drying rate and air velocity affects the cracked grain.
Türkiye, Hindistan ve Brezilya’daki Petrol Kiralarının Otoregresif Kesirli Bütünleşik Hareketli Ortalama (ARFIMA) Modeli ile Belirlenmesi
Authors: Sarıçam Semanur , Aşıkgil Barış
Published: August 2024

Petrol kiraları, üretim, ithalat ve tüketim vergileri üzerinden elde edilen gelir olduğu için enerji politikalarının bir parçası olarak değerlendirilir. Türkiye, Hindistan ve Brezilya gibi ülkelerin enerji politikaları, petrol ürünlerine yüksek vergiler uygulanmasından dolayı bu ülkelerin gelir elde etme yöntemlerinin bir parçasıdır. Petrol kiralarının ekonomide önemli rolü göz önüne alındığında, bu çalışma, bu ülkelerin 1970-2016 yıllarını kapsayan petrol kira verilerini kullanılarak uzun hafıza modellerinden biri olan otoregresif kesirli bütünleşik hareketli ortalama (ARFIMA) modeliyle incelemeyi amaçlamaktır. İlk aşamada, Türkiye, Hindistan ve Brezilya'nın petrol kira serilerinin durağan olup olmadığını belirlemek için klasik birim kök testleri uygulanmıştır. Sonrasında, serilerin uzun hafızaya sahip olup olmadığını değerlendirmek amacıyla Hurst'ün R/S istatistiği kullanılmıştır. İkinci aşamada ise p ve q değerleri 2'den küçük veya eşit olacak şekilde olası tüm otoregresif hareketli bütünleşik ortalama (ARIMA) ve ARFIMA modelleri test edilmiştir. En iyi model belirlenebilmesi için Akaike Bilgi Kriteri (AIC) ve Bayesci Bilgi Kriteri (BIC) iki temel bilgi kriterlerinden yararlanılmıştır. En uygun model belirlendikten sonra, bu model aracılığıyla geleceğe yönelik tahminler yapılmıştır.
A Production Inventory Model for Fractionally Time-Dependent Demand Rate with Weibull Deterioration and Partially Backlogged Items
Authors: Yadav Ritu , Sharma Anil Kumar , Singh Pujari Thakur
Published: August 2024

This article presents a report on a creation stock model that the point is to foster an ideal creation and stock procedure that boosts the general benefit while thinking about the impact of expansion on the decaying things over the long haul. The exponential demand rate is thought to accurately reflect real-world demand fluctuations over time. The model gives a manager’s realistic representation of the production and inventory system by considering these aspects, allowing them to make informed decisions. To enhance the creation and stock strategy, a numerical structure is created, consolidating different expense parts, for example, holding cost, arrangement cost, creation cost, and lack cost. The goal is to find the ideal creation amount and reorder point that limit the all-out cost and expand the general benefit. The proposed model's analytical results show a complex connection between the optimal production quantity, reorder point, and other relevant parameters. According to the findings, production inventory models must consider both the exponential demand rate and the inflation rate of deteriorating goods. The proposed model offers a pragmatic methodology for upgrading the creation and stock choices, at last improving the productivity and functional effectiveness of organizations managing crumbling things within the sight of expansion. This paper has followed an analytical approach to diminish the entire inventory cost. Finally, a sensitivity analysis was performed to study the effect of changes of different parameters of the model on the optimal policy. Moreover, in order to approve the determined models, we have clarified mathematical models and examined affectability.
Studies on Blend Beverage form Pomegranate (Punica granatum L.), Aonla (Emblica officinalis Gaertn.) and Aloe Vera (Aloe barbadensis Miller)
Authors: Neelam  , Deen Bhagwan
Published: August 2024

The pomegranate (Punica granatum L.), aonla (Emblica officinalis Gaertn.), and aloe vera (Aloe barbadensis miller.) have nutritional, medicinal, and therapeutic values. The present research was conducted at the Post Graduate Laboratory of the Department of Post Harvest Management, College of Horticulture and Forestry, Acharya Narendra Deva University of Agriculture & Technology, Kumarganj, Ayodhya (U.P.) during the year 2022–23. In the present studies, pomegranate juice, aonla juice and aloe vera gel were blended in different ratios viz., 100:0:0 (T1), 0:100:0 (T2), 0:0:100 (T3), 33.33:33.33:33.33 (T4), 40:30:30 (T5): 50:25:25 (T6), 60:20:20 (T7), 70:15:15 (T8), 80:10:10 (T9) and 90:5:5 (T10) for the preparation of RTS  10 percent of blend comprising 80 percent pomegranate juice, 10 percent aonla juice,10 percent aloe vera gel was found best on 9- point hedonic scale for the preparation of RTS with 13 percent TSS, 0.3 percent acidity and 120 ppm benzoic acid. than other blend combinations. Whereas ascorbic acid (vitamin C), non-reducing sugars, and organoleptic quality declined as the storage period progressed, TSS, acidity, reducing sugars, total sugars, and browning increased. At room temperature, the squash was kept. When stored at room temperature for five months, the beverage retained its organoleptic qualities. In terms of taste, colour, flavour, nutrition, and medicinal and therapeutic qualities, the current study showed that pomegranate, aonla, and aloe vera can be used to make palatable RTS that can benefit consumers.
Assessment of Drought Tolerance in Rabi Sorghum Genotypes under Polyethylene Glycol-induced Osmotic Stress
Authors: R Navyashree , U.V Mummigatti , P Nethra , B Basavaraj , N. G. Hanamaratti
Published: August 2024

Sorghum is a vital cereal crop globally, especially in arid and semi-arid regions of India, where rabi sorghum is critical for food security. This study investigates the impact of polyethylene glycol (PEG 6000)-induced osmotic stress on the germination, seedling growth, and vigor of twenty rabi sorghum genotypes. PEG 6000, a non-toxic osmotic agent, was utilized to simulate drought conditions by reducing water potential. The genotypes were subjected to three osmotic stress regimes (0%, 0.5%, and 1% PEG) and evaluated for germination percentage, root and shoot length, seedling dry weight, and seedling vigor indices. Results demonstrated significant variations in germination and seedling performance across genotypes and osmotic stress levels. The highest germination percentage was observed in ICSV-15017 (86.67%) under control conditions, while the lowest was in Annigeri-1 (23.33%) under 1% PEG. Shoot and root lengths decreased with increasing PEG concentration, with ICSV-15017 and SVD-1419 consistently showing superior growth under stress. Seedling dry weight and vigor indices also varied significantly, with DSV-5 and SVD-1419 exhibiting higher values compared to others under osmotic stress. The study identifies ICSV-15017, Parbani Motti, and DSV-4 as the most drought-tolerant genotypes, based on minimal reductions in germination percentage, seedling length, and vigour index under PEG-induced stress. In contrast, Annigeri-1 and ICSV-16006 showed limited drought tolerance. These findings highlight the effectiveness of PEG-induced osmotic stress for screening drought-tolerant sorghum genotypes and provide valuable insights for developing drought-resistant varieties in water-scarce regions.
Reservoir Management Structure A Field "RK" Using Water Injection Project Planning with the Suspended Well Reactivation Method
Authors: R Dyah Rini , Kristianti MTH , K Edgie , Rama Richard , Sigalingging Emi , Parwa Indar
Published: August 2024

In reservoir management to increase oil production in structure A of the "RK" Field with an area of ​​98.12ft2, a thickness of 76,124 ft, a porosity of 0.21%, and an initial water saturation of 0.25% which already matches the high watercut, it is necessary to plan water injection to increase the recovery factor. This is considered based on water availability, production performance results, and also from an economic perspective. The structure development study of "RK" Field A contains five active production wells and four suspended wells. Of the four suspended wells, one well was used as an injection well and three wells were reactivated to determine the effect of the waterflooding injection carried out using reservoir simulation methods by analyzing field petrophysical data such as oil saturation, permeability, and OPU maps. Based on the reservoir simulation, waterflooding injection was carried out in the AB_05 injection well with daily injection rates varying from 141 to 1200 BWIPD with injection pressures varying from 1782 to 2537 psi using one injection well. Based on the results of running simulations, the most optimal scenario is obtained with an injection rate of 750 BWIPD with an injection pressure of 2411 psi which produces a cumulative production of 4,687 MMSTB from 3.55 MMST, a recovery factor of 56,511% from 42.8% and a water cut of 60.9% from 43% so it is economical to carry out. water injection in structure A of the RK field.
Cadmium-induced Up-regulation of Nitric Oxide Synthase Activity in Rats' Testes: Ameliorative Effect of PurXcel
Authors: E. O. Aribo , J. N. Nwangwa , N. E. Udokang
Published: August 2024

Background: Cadmium is a common environmental pollutant and induces testicular dysfunction via mechanisms which include oxidative stress linked with inflammation. PurXcel is a polyherbal remedy said to be rich in antioxidants. The action of Cadmium on nitric oxide homeostasis and possible effect of the polyherbal on any functional aberration from this are not known and hence this study.
Methods: Twenty male Wistar rats were randomly assigned into control, Cadmium-only, PurXcel-only and Cadmium+PurXcel groups of five rats each. Duration of daily administration was 28 days after which animals were sacrificed and their testes dissected out for determination of necessary parameters.
Results: The results showed a significant increase (p≤0.05) in the testicular activity of Nitric Oxide synthase in the Cadmium-only group compared with the control but which was significantly lower in the PurXcel-only and Cadmium+PurXcel groups than in the Cadmium-only group(p≤0.05). The concentration of testicular nitric oxide was significantly increased in the Cadmium-only group compared with the control (p≤0.05) but significantly lower in the Cadmium+PurXcel and PurXcel-only groups than in the Cadmium-only group (p≤0.05). The levels were significantly higher in the Cadmium+PurXcel than in the PurXcel-only groups (p≤0.05).
Conclusion: In conclusion, PurXcel administration ameliorates Cadmium-induced up-regulation of Nitric Oxide Synthase activity and the resultant increase in the concentration of nitric oxide in rats testes. Therefore, dysregulation of Nitric Oxide homeostasis may play an important role in Cadmium-induced cytotoxicity.
Introduction and Management of Mustard Aphid [Lipaphis erysimi Kaltenbach (Homoptera: Aphididae)]: A Review
Authors: Dwarka  , Thakur Shobharam , Kumar Anil , Kumar Kailash , Parmar Shradha , Vishwakarma Deepali , Chadar Nisha
Published: August 2024

Mustard crops tend to be more vulnerable to various insect pests compared to other oilseed crops. This increased susceptibility is due to several factors, including the crop growth habits, environmental conditions, and the range of pests that specifically target mustard plants. One of the major causes of reduced production is the introduction of insects, such as L. erysimi (K.), B. brassica (L.), Athelia lugens proxima (K.), Pieris brassicae (L.), B. picta (K), Spodoptera litura (F.), Chromatomyia horticola (G.) Thrips tabaci and Bemesia tabaci (G.). Among them, Lipaphis erysimi K., is the most destructive pest in India and is present in many other nations. It is also discovered that the most favored crop for sucking complexes. Aphids are small, soft-bodied insects with a pearl-like shape and two cornicles, or honey tubes extending from the 5th or 6th abdominal segment. They go through four instars or nymphal stages before reaching adulthood. The abdomen of winged female aphids is a dark green color marked by dark lateral stripes between the body sections and dark veins on the wings. Aphids in males are typically olive-green to brown. The infestations usually begin in December and persist until March, thriving at temperatures of 20°C or lower. Cloudy and cold weather conditions further promote their growth. Aphids can produce about 45 generations annually.
Kinetic Resolution of 1,1′‐Biaryl‐2,2′‐Diols and Amino Alcohols through NHC‐Catalyzed Atroposelective Acylation
Authors: Lu Shenci , Poh Si Bei , Zhao Yu
Published: August 2014

We present here a highly efficient NHC‐catalyzed kinetic resolution of a wide range of 1,1′‐biaryl‐2,2′‐diols and amino alcohols to provide them in uniformly ≥99 % ee. This represents the first highly enantioselective catalytic acylation of axially chiral alcohols. The aldehyde backbone that is incorporated into the chiral acyl azolium intermediate was found to have a significant effect on the enantioselectivity of the process.
FACTORING THE MULTITEST‐MULTIOCCASION CORRELATION MATRIX*
Authors: Jo̎reskog K. G.
Published: August 2014

In this paper we consider various models for analyzing multitest‐multioccasion data such as obtained in growth studies where several tests have been administered to the same examinees at several occasions. A general model is described first and then some special cases of this model are studied in greater detail. It is shown that all models are special cases of an even more general model proposed and investigated by Jo̎reskog (1969b). The estimation and testing problems may be handled by an analysis of this model. Two methods for estimating the parameters of the models are considered: the least squares method and the maximum likelihood method. One model is illustrated by means of some growth data.
Emotion regulation in first episode adolescent non‐suicidal self‐injury: What difference does a year make?
Authors: Voon David , Hasking Penelope , Martin Graham
Published: August 2014

We examined the roles of cognitive reappraisal, expressive suppression, and rumination in first episode non‐suicidal self‐injury (NSSI) among adolescents, and the impact of age‐related differences in emotion regulation use. Adverse life events and psychological distress played a significant role in NSSI onset. Being male and less use of cognitive reappraisal contributed to NSSI risk but only in regard to 12‐month incidence; this effect was not observed when predicting 24‐month incidence. Neither expressive suppression nor rumination was related to NSSI onset in our sample. Age‐related differences in emotion regulation were found, but did not modify the above relationships. Findings hint at the possible impact of developmental changes in adolescents' cognitive‐emotional processing and their subsequent risk of NSSI. Results support further investigation into prevention and early intervention initiatives aimed at assisting adolescents cope with acute life stressors to prevent/delay first episode NSSI.
Implementierung von Studienergebnissen
Authors: Roes Martina
Published: August 2014

Täglich muss sich die Pflegepraxis mit Neuigkeiten auseinanderzusetzen: einmal sind es im Rahmen von Studien entwickelte Assessmentinstrumente zur besseren Einschätzung des Zustands eines Pflege Bedürftigen, ein anderes Mal sind es Neuerungen zur Wundversorgung oder es gibt unsichere Hinweise auf die Wirksamkeit komplexer Interventionen. Immer wieder müssen Pflegenden entscheiden, ob es sich bei diesem Wissen um relevante Evidence handelt und wenn ja, wie dies ihren Alltag beeinflusst.
RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage
Authors: Nugues A-L , El Bouazzati H , Hétuin D , Berthon C , Loyens A , Bertrand E , Jouy N , Idziorek T , Quesnel B
Published: August 2014

The receptor-interacting protein kinase 3 (RIP3) associates with RIP1 in a necrosome complex that can induce necroptosis, apoptosis, or cell proliferation. We analyzed the expression of RIP1 and RIP3 in CD34+ leukemia cells from a cohort of patients with acute myeloid leukemia (AML) and CD34+ cells from healthy donors. RIP3 expression was significantly reduced in most AML samples, whereas the expression of RIP1 did not differ significantly. When re-expressed in the mouse DA1-3b leukemia cell line, RIP3 induced apoptosis and necroptosis in the presence of caspase inhibitors. Transfection of RIP3 in the WEHI-3b leukemia cell line or in the mouse embryonic fibroblasts also resulted in increased cell death. Surprisingly, re-expression of a RIP3 mutant with an inactive kinase domain (RIP3-kinase dead (RIP3-KD)) induced significantly more and earlier apoptosis than wild-type RIP3 (RIP3-WT), indicating that the RIP3 kinase domain is an essential regulator of apoptosis/necroptosis in leukemia cells. The induced in vivo expression of RIP3-KD but not RIP3-WT prolonged the survival of mice injected with leukemia cells. The expression of RIP3-KD induced p65/RelA nuclear factor-κB (NF-κB) subunit caspase-dependent cleavage, and a non-cleavable p65/RelA D361E mutant rescued these cells from apoptosis. p65/RelA cleavage appears to be at least partially mediated by caspase-6. These data indicate that RIP3 silencing in leukemia cells results in suppression of the complex regulation of the apoptosis/necroptosis switch and NF-κB activity.
Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy
Authors: Tachikawa Shoji , Miyoshi Tatsuro , Koganei Hayato , El-Zaria Mohamed E. , Viñas Clara , Suzuki Minoru , Ono Koji , Nakamura Hiroyuki
Published: August 2014

Significant anti-tumor effects and longer survivals were observed in the tumor-bearing mice treated with spermidinium closo-dodecaborate-encapsulating liposomes after thermal neutron irradiation.