bluuebunny/crossref_metadata_2025 huggingface dataset:
Crosstalk between mitochondrial homeostasis and AMPK pathway mediate the receptor-mediated cardioprotective effects of estradiol in ovariectomized female rats
Authors: Gowayed Mennatallah A. , Zakaraya Zainab Zaki , Abu-Samra Nehal , Elhamammy Reem H. , Abdel Moneim Lobna M. , Hafez Hala A. , Moneam Ihab A. , Oriquat Ghaleb A. , Kamel Maher A.
Published: December 2024

Estrogen (E2) deficiency is a risk factor for cardiovascular disease (CVD), however, the exact mechanism for the E2 protective effect on CVD remains unclear. This study aimed to investigate the estrogen receptor (ER) and non-receptor mediated effects of E2 treatment on the cardiac expression of adenosine monophosphate-dependent protein kinase (AMPK), autophagic, mitophagy and mitochondrial homeostasis-regulating genes in ovariectomized (OVX) rats. Female rats were divided into two main groups; sham and bilaterally OVX rats, then each group was subdivided into four subgroups according to treatment; untreated, subcutaneously treated with E2 (30 μg/kg), or Fulvestrant (F) (5 mg/Kg), or a combination of both drugs for 28 days. The OVX rats or F-treated sham rats showed dyslipidemia, and marked disturbances in parameters of AMPK signaling, autophagy, mitophagy, mitochondrial fission, fusion and biogenesis. E2 administration to OVX or F-treated sham rats has corrected the disturbed lipid and cardiac profiles, increased AMPK, and restored the balance of cardiac autophagy, mitophagy, and mitochondrial dynamics and homeostasis. Most of these effects in OVX rats were blocked by the ER antagonist (F). Estrogen treatment has cardioprotective effects in OVX females through modulating cardiac mitochondrial homeostasis, mitophagy and autophagy and restoring the AMPK signaling pathway. As witnessed by Fulvestrant, these effects suggest the main role of ER-mediated signaling in regulating mitophagy and plasma and cardiac lipids along with the existence of a post-translational control mechanism or the involvement of estrogenic non-receptor pathway controlling the postmenopausal cardiac mitochondrial energy production machinery that needs further investigation.
A 13,000-year history of vegetation and fire in a rare inland pine barrens: The Albany Pine Bush (Albany County, New York, USA)
Authors: Tremblay Megan , Stager J. Curt , St-Jacques Jeannine-Marie , Murphy Skylar , Peros Matthew , Carl Brian S.
Published: December 2024

Two radiocarbon-dated pollen and charcoal records from cores collected at Stump Pond and a wetland in suburban Albany County, New York, provide new insights into the environmental history of a unique inland pine barrens that is currently surrounded and threatened by urban development: the Albany Pine Bush (APB). The Stump Pond core shows that the pond formed roughly 13,000 years ago with the recession of glacial Lake Albany. From ca. 13,000 to 11,000 years ago spruce (Picea) and other boreal forest taxa were more common in the region than they are today, but both cores show that pine-oak (Pinus-Quercus) assemblages similar to those of today’s APB have been predominant components of the local forests for the last ca. 11,000 years. Abundant charcoal in both cores demonstrates that fire activity was a frequent occurrence in the APB throughout its history, particularly for the last ca. 6400 years. Water tables rose in response to increasingly humid hydroclimates, leading to the establishment of the wetland site ca. 6400 years ago and a greater abundance of ferns and mosses there during the last millennium. More recently, expanding urbanization and its associated impacts demonstrate that human activity has become the primary driver of change in the APB ecosystem.
Andean bears (Tremarctos ornatus) display selective behaviors while foraging bromeliads (Puya spp.) in high elevation puna grasslands
Authors: Pilfold Nicholas W. , Mateo-Chero Denisse , Farfan-Rios William , Watsa Mrinalini , Owen Megan A. , Van Horn Russell C.
Published: December 2024

Andean bears (Tremarctos ornatus) forage extensively on bromeliads (Puya spp.) across their range, although their selectivity for bromeliads is less understood. We report on foraging activity by Andean bears on two species of bromeliad, Puya leptostachya and Puya membranacea, in high elevation puna grasslands (3499–3806 m.a.s.l) within and near Manu National Park (MNP) in SE Peru. We established two ridgeline transects (inside and outside MNP) with perpendicular transects running downslope. We recorded whether bromeliad plants were foraged by Andean bears on four separate sampling occasions that included wet and dry seasons from July 2017 to August 2018. We observed foraging by Andean bears at 6.8% of the available individual plants spread across 16.7% of the available patches. We utilized Resource Selection Functions to evaluate the environmental factors influencing the selection of bromeliad patches by Andean bears for foraging. Andean bears showed selection for Puya leptostachya over Puya membranacea, preferring to forage during the dry season at higher density patches of younger vegetative-stage bromeliads, possibly due to the increased bioavailability of nutrients in the basal meristematic plant tissue the bears prefer to eat. Andean bears selected bromeliad patches growing on east-facing, steep, high-altitude slopes, in a band near the cloud forest edge, which likely reflected a combination of optimal growing conditions for the bromeliads and habitat selection by the bears. Observations of foraging on grassland bromeliads occurred almost exclusively within the boundaries of MNP, which may in part reflect bears avoiding cattle impacts outside of the park. Andean bears showed active behavioral selection for bromeliads within the puna grasslands, and we recommend that grassland buffers around the cloud forest should be considered as primary habitat in conservation management plans.
Factors associated with anxiety and fear of falling in older adults: A rapid systematic review of reviews
Authors: Whitmore Carly , Neil-Sztramko Sarah , Grenier Sebastien , Gough Amy , Goodarzi Zahra , Weir Erica , Niculescu Iulia , Suthakaran Abitha , Adedeji Isaac , Akram Mahnoor , Mojgani Juliette , Chan Titus , Flint Alastair J. , Juola Heli , Reynolds Kristin , Trenaman Shanna , Van Amerigen Michael , Yeung Anthony , Levy AnneMarie , Iaboni Andrea
Published: December 2024

Background

Anxiety disorders are prevalent amongst older adults and negatively impact their quality-of-life and health. Anxiety disorders often go undetected or are misattributed to age-related changes. The aim of this systematic review of reviews, was to synthesize existing evidence on risk factors associated with anxiety in older adults to improve opportunities for early detection and intervention.

Methods

A rapid systematic review of reviews was performed. Studies were included if they were systematic reviews, specific to older adults, reported modifiable or non-modifiable factors associated with increased or decreased frequency of anxiety, and reported on anxiety disorders or symptoms of anxiety (including fear of falling).

Results

27 papers met criteria for inclusion. A total of 77 unique risk and protective factors across demographic, health, environmental, and psychosocial domains were identified. Recurrently identified risk factors for anxiety included female sex, health (e.g., multimorbidity, sensory impairments), physical functions (e.g., impaired balance, history of falls), psychological factors (e.g., fear of falling, depression), social isolation, and sleep disturbances, whereas good physical health and balance confidence were protective.

Conclusions

This review reinforces the multifaceted and complex nature of anxiety in older adults. The results synthesized, highlight risk factors that should prompt detection of older adults for anxiety disorders and provide valuable insight for the development of tailored detection tools that better identify older adults at risk. Future research should address methodological limitations and include more diverse populations to improve opportunities for early detection and intervention in this vulnerable population.
Prevalence and associations of problematic smartphone use with smartphone activities, psychological well-being, and sleep quality in a household survey of Singapore adults
Authors: Ong Rebecca Hui Shan , Sim Hui Shan , Bergman Manfred Max , How Choon How , Png Constance Ai Li , Lim Chau Sian , Peh Lai Huat , Oh Hong Choon
Published: December 2024

Introduction

Despite the many benefits of smartphones, researchers have raised concerns over problematic smartphone use (PSU) and its negative effects on physical and psychological well-being. Studies examining PSU and its impact among adults remain limited. Hence, we aim to examine the prevalence of PSU among adults in Singapore, and explore its associations with smartphone activities, sleep quality, and psychological well-being, as well as age and gender-related differences in these associations.

Methods

A household survey (n = 1200) was conducted among multi-ethnic Singapore adults aged 21 to 60. The survey employed a proportionate stratified random sampling approach. The Smartphone Addiction Scale–Short Version was used to determine risk of PSU. Adjusted multivariable logistic regressions, age-stratified (21–30, and above 30) analyses and sensitivity analyses were performed.

Results

The survey response rate was 45.7%. PSU prevalence rate was estimated to be 34.0%. Adults at risk were younger (OR = 3.72, p < 0.001), had poor sleep quality (OR = 2.94), reported depressive (OR = 2.84, p = 0.001) or anxiety symptoms (OR = 2.44, p < 0.001), tend to use smartphones for social media (OR = 2.81, p = 0.002) or entertainment (OR = 2.72, p < 0.001). Protective factors include higher levels of social support (OR = 0.76, p = 0.007), using smartphones for calling family (OR = 0.39, p = 0.003) and friends (OR = 0.53, p = 0.030), and spending four hours or less of smartphone usage duration (OR = 0.40, p < 0.001). Sensitivity analyses confirmed these findings. Associations between PSU and poor sleep quality (OR = 3.72, p < 0.001), depressive (OR = 3.83, p < 0.001), and anxiety symptoms (OR = 2.59, p = 0.004) and social media usage (OR = 3.46, p < 0.001) were more pronounced in adults over 30. PSU was more prevalent among females in those aged 21–30 (OR = 2.60, p = 0.022). Social support appears to be a protective factor for adults over 30 (OR = 0.64, p < 0.001) but was not observed in those aged 21–30. Among males, younger age (21–30 years), poor sleep quality, depressive symptoms, and anxiety symptoms, and using social media and entertainment apps were significantly associated with PSU. Females showed similar associations. Social support appears to be a protective factor for females (OR = 0.70, p = 0.018), but this association was not observed for males. Shorter smartphone usage times were inversely associated with PSU in both genders.

Conclusion

A substantial proportion of adults exhibited PSU. Findings highlight the differential associations between PSU and psychological well-being, social support, interactions with technology, and sleep quality. These associations are influenced by age which has implications for preventive efforts.
Towards 90-70-90 targets: Individual and community level factors associated with cervical cancer screening among women of reproductive age in Tanzania: A multi-level analysis based on 2022 Tanzania demographic and health survey
Authors: Asgedom Yordanos Sisay , Hailegebireal Aklilu Habte , Woldegeorgis Beshada Zerfu , Koyira Mengistu Meskele , Seifu Beminate Lemma , Fente Bezawit Melak , Gebrekidan Amanuel Yosef , Tekle Habtamu Azene , Asnake Angwach Abrham , Kassie Gizachew Ambaw
Published: December 2024

Introduction

Cervical cancer is a major public health problem worldwide, and is mainly caused by human papillomaviruses. More than 90% of cervical cancer cases can be prevented by using a human papilloma vaccine and screening. Despite the ongoing global cervical cancer screening target, uptake remains unacceptably low in sub-Saharan Africa such as Tanzania. Although cervical cancer is the leading cause of mortality in Tanzania, evidence on the individual- and community-level factors associated with cervical cancer screening among women of reproductive age is scarce. Therefore, this study aimed to determine the individual- and community-level factors associated with cervical cancer screening among women of reproductive age in Tanzania.

Methods

This study used data from the 2022 Tanzania Demographic and Health Survey (TDHS). A weighted sample of 15,140 women of reproductive age was included in this study. Given the effect of clustering and binary nature of the outcome variable, we used a multilevel binary logistic regression model. The adjusted odds ratio (AOR) with 95% Confidence Interval (CI) was statistically significant. Moreover, the model with the lowest deviance best suited the data.

Results

The overall uptake of cervical cancer screening among Tanzanian women was 7.28% (95% confidence interval [CI]: 6.87%, 7.70%). Women’s age (25–34, 35–49), women with primary, secondary, and higher educational levels, being employed, a high household wealth index, visiting health facilities in the last 12 months, owning mobile phones, urban residence, and southern highlands, Southern, and Zanzibar administrative zones, were significantly associated with cervical cancer screening.

Conclusion

Cervical cancer screening among women in Tanzania was low. Low uptake underscores the need for increased focus on addressing the coverage of the 2030 Sustainable Development Goals (SDGs). The study would help policymakers create programs that consider education, employment, visiting health facilities, mobile phones, wealth, residence, and administrative zones, which would make women undergo cervical cancer screening. Pointing to women living with low cervical cancer screening could help increase their uptake and achieve the targets of the national and World Health Organization.
Assessing the impact of apnea duration on the relationship between obstructive sleep apnea and hearing loss
Authors: Jo Yong Seok , Lee Jeon Mi
Published: December 2024

Objectives

The relationship between obstructive sleep apnea (OSA) and hearing loss (HL) remains uncertain. This study aimed to investigate the relationship between OSA and HL, and to identify which factors play a key role.

Methods

A retrospective review was conducted of 90 subjects diagnosed with OSA. These subjects underwent overnight polysomnography (PSG) and pure-tone audiometry at a single institution from February 2014 to November 2023. Hearing evaluations involved the comparison of OSA subjects with a non-OSA group, identified through national data utilizing the STOP-BANG questionnaire (SBQ) and age-sex 1:1 matching. Subsequently, individuals with OSA were categorized into HL and non-HL groups. Comparisons were made to ascertain differences in PSG parameters, followed by regression analysis to assess their actual impact.

Results

The OSA group exhibited elevated hearing thresholds across all frequencies compared to the non-OSA group. Furthermore, classification of OSA subjects into the HL and non-HL groups revealed a statistically significant increase in apnea duration in the HL group for all-frequency and high-frequency cases (p = 0.038, 0.006). Multiple linear regression analysis, adjusting for age and sex, revealed a significant influence of apnea duration on HL in both all-frequency and high-frequency cases (ß = 0.404, p = 0.002; ß = 0.425, p = 0.001).

Conclusion

These findings underscore the significant association between OSA and reduced auditory function, with apnea duration standing out as a crucial factor contributing to hearing loss. Our results suggest that prolonged apnea duration may be a marker of chronic hypoxic damage in patients with OSA, further clarifying its potential role in the development of hearing loss.
Prevalence and predictors of functional gastrointestinal disorder among the undergraduate students of Bangladesh
Authors: Roy Simanta , Eva Fahima Nasrin , Dev Dipa , Roy Sanchita , Tipu Shafkat Kamal , Chowdhury Sristi , Medha Madhu Ritu Bhadra , Poonya Purzia Tanaz Haque , Juthi Israt Jahan , Nowrin Jwearia Hoque , J. C. Eaasvar , Sumat Tahsin , Dey Disha Mony , Chowdhury Sreshtha , Iktidar Mohammad Azmain , Hawlader Mohammad Delwer Hossain
Published: December 2024

Objective

This study aimed to address this knowledge gap by investigating FGID prevalence and its predictors among undergraduate students in Bangladesh.

Design

This cross-sectional study was conducted between 01 August 2023 and 31 January 2024 among 1,019 undergraduate students. Data were collected using a web-based survey containing questions on socio-demographics, the Rome IV questionnaire, the insomnia severity index, the perceived stress scale 4, the patient health questionnaire, and the smartphone addiction scale. Descriptive statistics, the chi-square test, the t-test, and the multivariable logistic regression model were used to report our study findings.

Results

The overall prevalence of FGID was 38.24%, with functional constipation being the most common subtype (18.24%). The multivariate analysis revealed that college canteen meal (AOR: 1.593, CI: 1.068, 2.376), occasionally and regularly delayed meal (AOR: 1.663, CI: 1.031, 2.682; AOR: 1.872, CI: 1.061, 3.301), physical inactivity (AOR:0.41, CI: 1.061, 3.301), family history of FGID and GI disease (AOR: 4.7, CI: 2.55, 8.66; AOR: 2.42, CI: 1.47, 3.96), history of abdominal surgery (AOR: 2, CI: 1.08, 3.72), psychological trauma (AOR: 1.64, CI: 1.04, 2.57), dairy-product consumption (AOR: 1.64, CI: 1.04, 2.59), >3 meals/day (AOR: 1.89, CI: 1.2, 2.98), insomnia (AOR: 1.98, CI: 0.73, 5.40), and depression (AOR: 7.02, CI: 2.74, 17.98) were significantly associated with FGID.

Conclusion

The burden of FGIDs among Bangladeshi students is concerning. This study found significant factors contributing to their prevalence, including meal source and number of daily meals, delayed meals, family history of disease, physical activity, abdominal surgery, history of psychological trauma, depression, and insomnia. This study recommends further exploration and holistic healthcare approaches to better the well-being of young adults dealing with FGIDs.
Immunopeptidomic MHC-I profiling and immunogenicity testing identifies Tcj2 as a new Chagas disease mRNA vaccine candidate
Authors: Versteeg Leroy , Adhikari Rakesh , Robinson Gonteria , Lee Jungsoon , Wei Junfei , Islam Nelufa , Keegan Brian , Russell William K. , Poveda Cristina , Villar Maria Jose , Jones Kathryn , Bottazzi Maria Elena , Hotez Peter , Tijhaar Edwin , Pollet Jeroen
Published: December 2024

Trypanosoma cruzi is a protozoan parasite that causes Chagas disease. Globally 6 to 7 million people are infected by this parasite of which 20–30% will progress to develop Chronic Chagasic Cardiomyopathy (CCC). Despite its high disease burden, no clinically approved vaccine exists for the prevention or treatment of CCC. Developing vaccines that can stimulate T. cruzi-specific CD8+ cytotoxic T cells and eliminate infected cells requires targeting parasitic antigens presented on major histocompatibility complex-I (MHC-I) molecules. We utilized mass spectrometry-based immunopeptidomics to investigate which parasitic peptides are displayed on MHC-I of T. cruzi infected cells. Through duplicate experiments, we identified an array of unique peptides that could be traced back to 17 distinct T. cruzi proteins. Notably, six peptides were derived from Tcj2, a trypanosome chaperone protein and member of the DnaJ (heat shock protein 40) family, showcasing its potential as a viable candidate vaccine antigen with cytotoxic T cell inducing capacity. Upon testing Tcj2 as an mRNA vaccine candidate in mice, we observed a strong memory cytotoxic CD8+ T cell response along with a Th1-skewed humoral antibody response. In vitro co-cultures of T. cruzi infected cells with splenocytes of Tcj2-immunized mice restricted the replication of T. cruzi, demonstrating the protective potential of Tcj2 as a vaccine target. Moreover, antisera from Tcj2-vaccinated mice displayed no cross-reactivity with DnaJ in lysates from mouse and human indicating a decreased likelihood of triggering autoimmune reactions. Our findings highlight how immunopeptidomics can identify new vaccine targets for Chagas disease, with Tcj2 emerging as a promising new mRNA vaccine candidate.
Transitioning through drawing
Authors: Saunders Janet
Published: December 2024

‘Transitioning through drawing’ is a series of works on paper that explore the value and role of drawing to alleviate the emotional distress and isolation experienced by people experiencing illness, while also facilitating opportunities for contemplation and inquiry into the clinical procedures through an aesthetic lens. This series reflects a practice-led enquiry that stemmed from the artist’s exploration of various forms of drawing within their creative practices. Drawing experiments included marks made by oil paint across water and movements of the body on an inked glass surface, both of which created imprints on large sheets of paper. These marbled surfaces and body monoprints became the foundation for further additions, including forms, surface marks and textures. The phenomenological nature of these drawings, combined with the physical act of creating them, mirrors the diagnostic process of searching for disease and decay within the body through medical imaging. Through this artistic lens, the drawings evoke the shared experience of vulnerability.
Hulladékgazdálkodási esettanulmányok feldolgozása
Authors: Vuk Aliz , Bauerné Gáthy Andrea
Published: December 2024

A települési szilárd hulladékgazdálkodás terén a világ
országai más és más nehézségekbe ütköznek. Az évente keletkező
hulladék mennyiségének csökkentése érdekében a körforgásos
gazdaság bevezetése egy lehetséges megoldás lenne. Viszont a
különféle helyzetben levő, különböző gazdasági fejlettségű
országokban eltérő megközelítéseket figyelhetünk meg. A
tanulmányban 7 esettanulmány feldolgozása alapján mutatjuk be és
értékeljük a vizsgált országokat hulladékgazdálkodásuk
szempontjából. A magasabb gazdasági fejlettségű országoktól
(Olaszország, Finnország, Dél-Korea) egészen az alacsony gazdasági
fejlettségű országokig (Brazília, Afrika) vizsgáltunk meg
eseteket. Jó gyakorlatokat találtunk, ilyen São Tomé városa is,
ahol a helyi közösség maga szervezte meg a hulladékgazdálkodását.
Értékeltünk olyan esetet is, ahol a politikai döntéshozatalban
megjelenik a körforgásos gazdaság, de a megvalósításában még több
minden megkérdőjelezhető. Az viszont mindenhol elmondható, hogy a
közösségi összefogás és a fogyasztók tudatossága egy kulcs pontja
a haladásnak. Ezen kívül az önkormányzatok részvétele és a
szervezeti együttműködés elengedhetetlen a hatékony és sikeres
hulladékkezeléshez.
Az energiaválság optimális részvénybefektetői döntésekre
gyakorolt hatása
Authors: Csontos György , Gergő Tömöri
Published: December 2024

A 2020-as években lezajló válsághelyzetek különösképpen
erős hatást gyakoroltak az eurózónán kívül eső, így pénzügyileg
sérülékenyebb és a kiéleződött geopolitikai konfliktusoknak
kitettebb közép-európai országokra, illetve azon belül is, a
válságra sajátos kormányzati válaszreakciókat adó Magyarországra.
Kutatási célunk volt a zöldítési politika, a Covid utáni
újranyitás és az orosz energiahordozók importját érintő, európai
uniós szankciós politika együttes következményeképpen kialakuló
energiakrízis hatásának vizsgálata a magyarországi részvénypiacra
fókuszálva, melyet a blue chipek, illetve az energetikai
üzletágban érdekelt ALTEO Nyrt. részvényeinek elemzésén és az
azokból kialakított portfóliók optimalizálásán keresztül végeztünk
el. Ennek keretében kívántuk meghatározni, hogy egy, az előbbi 5
részvényből összeállított portfólió variancia és Gini-index alapon
optimalizált struktúrájára milyen hatást gyakoroltak a 2020-2023
közötti időszak turbulens válságjelenségei, kiemelten az
energiaárak inflációjára. Mivel mindkét metódus bár eltérő
mértékben, de az energiaválság hatására ugyanazon, energetikában
érdekelt társaság részvényeinek portfólióban betöltött súlyát
növelte meg szignifikánsan, így kijelenthető, hogy a diverzifikált
portfólió összetételének változása visszatükrözte a makrogazdasági
körülmények részvénypiacra gyakorolt hatásait.
CRIATIVIDADE COMO COMPETÊNCIA PRESENTE NA BASE NACIONAL COMUM CURRICULAR (BNCC):
Authors: Nakano Tatiana
Published: December 2024

A criatividade vem sendo valorizada como uma das competências essenciais no século XXI. Dentre os contextos em que o desenvolvimento dessa característica tem sido buscado, o ambiente escolar se destaca, onde tem sido desenvolvida, intencionalmente, no cenário internacional. Consequentemente, nos últimos anos, diferentes políticas públicas passaram a incluir a criatividade como uma das metas do ensino brasileiro, sendo que, dentre elas, a Base Nacional Comum Curricular (BNCC) pode ser considerada a mais importante. É nesse cenário que o presente estudo, de análise documental foi desenvolvido, tendo como objetivo principal, compreender como a criatividade foi enfocada na BNCC. A revisão do documento foi realizada, buscando-se identificar trechos em que há referência direta a essa competência, nos diferentes níveis educacionais que compõem a educação básica (educação infantil, ensino fundamental e ensino médio). Os resultados são apresentados, juntamente com uma análise da situação atual relacionada à sua implementação prática no processo de ensino-aprendizagem.
NARRATIVAS PARA ALÉM DA PALAVRA
Authors: Ney Lilian da Silva , Dorneles Aline Machado
Published: December 2024

Este texto de cunho narrativo é um convite a que possamos pensar e sentir sobre possibilidades outras de pesquisar e conversar acerca de nossas práticas educativas e investigativas em educação. Investigar narrativamente nossas práticas, flerta com uma escrita e uma escuta atenta e amorosa, apostando nas narrativas como possibilidade de potencializar as práticas educativas, estudos e experiências nos/dos/com os cotidianos e os saberes e fazeres que acontecem nas universidades e nas escolas. Neste sentido, o presente artigo tece reflexões  sobre o devaneio como proposta de artesania narrativa, a deriva como possibilidade de ressignificar o vivido e a própria narrativa como um fazer poético. Investigar narrativamente o que se passa no cotidiano, tomando a prática como centralidade, é colocar a experiência do sujeito no centro do debate. Somos constituídas de histórias, únicas e singulares, narramos nossas experiências e memórias, compartilhamos saberes e conhecimentos buscando tecer outras reflexões teórico-metodológicas ao nos reinventarmos através da narrativa, em um processo de (auto)formação pessoal em conversa com a memória individual e coletiva. Uma formação singular habitada por muitas “pessoinhas”, com nossas histórias e biografias singulares e plurais, individuais e coletivas, pois somos feitas de histórias, de muitas histórias passadas, presentes e futuras. Viver de utopias, sonhos, devaneios, metáforas, presenças, ausências, atravessamentos, encantamentos, é um convite a investigar e compartilhar narrativamente essas experiências.
Unveiling digital pedagogy tools for citizenship through a child-led study setting
Authors: Demiral Seran
Published: December 2024

This article aims to propose a child-led study setting as a bottom-up community-building approach concerning children’s engagement in digital environments. Beginning with a theoretical framework addressing the boundaries and intersections between participation and engagement, it initiates a discussion on children’s presence in the research field. This discussion is grounded in the preparation and implementation of a small-scale case study on the digital citizenship experiences of children in Istanbul, Türkiye. Viewed through a critical lens that examines the relationships among participants and contributors, including the researcher and the study’s leader/co-researchers (which include children), this article also touches on the incorporation of children into democratic processes, discussions and decision-making. Since individuals under the age of 18 are often regarded as partial citizens who are excluded from social life and political decision-making processes, this field study aims to promote an understanding of digital citizenship within the context of social, political and cultural engagement. Following the principles of democratic participation, this study takes into account the potential of social media and digital tools as spaces where different segments of society intersect and converge, thereby enhancing the participation of children and adolescents transitioning into adulthood across various domains of life.
In memory of Tatyana Gratsievna Voznesenskaya
Authors: Article Editorial
Published: December 2024

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The Language Environment of Santri at Salaf Islamic Boarding School in Cirebon
Authors: Uctuvia Vina , Jaza Zimam Farid Hadi
Published: December 2024

This research delves into the linguistic intricacies within the Salafi Islamic boarding school situated in Babakan, Ciwaringin, Cirebon—a microcosm of diversity in social and linguistic backgrounds. Employing a descriptive qualitative design with a sociolinguistic approach, the study explores language maintenance and shift among the students, emphasizing the intricate interplay between language and social contexts. Through the Simak Bebas Libat Cakap 'observation' technique, questionnaires, and interviews, the data unveils a dynamic coexistence of language maintenance and shift, notably observed in Bahasa Cirebon, Indonesian, and regional languages. Native speakers exhibit resilience in using Bahasa Cirebon during interactions with diverse interlocutors, while language shift occurs when individuals with distinct linguistic backgrounds opt for languages other than the regional one in communicative events. This research not only provides insights into linguistic resilience within the Salafi pesantren community but also highlights the adaptability of regional languages in multifaceted linguistic environments. The incorporation of the Unified Regional Linguistic Resilience Theory enriches the theoretical underpinning, offering a comprehensive lens for comprehending language dynamics in Islamic boarding schools. This contribution extends to the broader discourse on language, identity, and communication, emphasizing the significance of regional languages in diverse sociocultural settings.
Translation Method in Song Lyric “Cintanya Aku” From Indonesian to English
Authors: Sihite Rani Amelia , Marbun Waldi , Hutabarat Sabrina Wandani , Saragih Frans Ananda
Published: December 2024

This study analyzes the translation methods in the lyrics of the song "Cintanya Aku" from Indonesian to English. In the process of translation analysis, the researcher uses the theory of translation methods based on Newmark's theory, namely word-for-word translation, literal translation, faithful translation, semantic translation, adaptation, free translation, idiomatic translation, and communicative translation. This research uses descriptive qualitative method in analyzing the data. The problems discussed in this study are: 1. What is the meaning of the lyrics of the song "Cintanya Aku" into English? 2. What translation method is used by the translator to translate the lyrics of the song "Cintanya Aku" into English? Finally, the researcher found that the most dominant method which is used by the translator is Free translation. This free translation prioritizes the overall meaning and impact of the source text over a direct word-for-word translation.
Impacto de las decisiones de la Corte IDH: lograr su modulación desde la tradición constitucional colombiana
Authors: Zarabanda Suárez Diana Marcela
Published: December 2024

Mantener la armonía entre las decisiones de la Corte Interamericana de Derechos Humanos y las legislaciones de sus Estados parte puede convertirse en una tarea engorrosa y compleja. El caso colombiano frente a la configuración de su régimen disciplinario se ha convertido en la perfecta evidencia de ello, por cuanto ha mostrado la capacidad del Tribunal Supranacional de ejercer control de convencionalidad sobre normas constitucionales generando tensiones jurídicas que, en el intento de mitigarlas, pueden producir inconvenientes internos todavía peores. Este documento ejemplifica esa situación y propone una fórmula para identificar dichas tensiones y mitigarlas en un caso concreto.
La migración y sus implicaciones en el mundo del trabajo en Colombia
Authors: García Jiménez Sneyder , Ostau de Lafont de Leon Francisco Rafael , Niño Chavarro Ángela
Published: December 2024

Los fenómenos como la pobreza, la discriminación y la violencia han producido el desplazamiento de la fuerza laboral, como respuesta de supervivencia del ser humano. Este artículo tiene como propósito establecer las implicaciones de los estándares del Pacto mundial para la migración segura, ordenada y regular (GCM) en los derechos humanos laborales en Colombia, a partir de la sociología de la migración con perspectiva sociojurídica. Se concluye con algunos criterios para el empleo de estándares internacionales de gobernanza para la migración y su protección internacional, como medida para restablecer el multiculturalismo desde la marginación del transnacionalismo. Ello, en el marco de la responsabilidad de los Estados en la garantía de los derechos humanos laborales.
La criminología predictiva: ¿un futuro próximo o una ficción en lontananza?
Authors: Pérez Salazar Bernardo
Published: December 2024

Este artículo presenta un análisis de la incorporación de modelos estadísticos predictivos para asistir la operación del enfoque de policía predictiva en la prevención de delitos en grandes centros urbanos. Se discuten las experiencias documentadas en la literatura reciente especializada sobre el desarrollo y el ajuste de modelos predictivos basados en aprendizaje automático (machine learning), su aplicación en el marco del enfoque de policía predictiva y sus limitaciones. Luego examina, de forma crítica, los efectos del uso del aprendizaje automático en el campo más amplio de la criminología predictiva, en especial en relación con la reducción de homicidios. Concluye con una discusión sobre los aportes potenciales de la criminología predictiva a la gestión de la seguridad ciudadana en grandes centros urbanos.
Scientific Diplomacy: An Opportunity for Security and National Defense in Colombia
Authors: Navas Camargo Fernanda Johanna
Published: December 2024

The present paper introduces the concept of Science Diplomacy for Security and Defense in Colombia as a means to pursue Soft Power activities that can contribute to both the perception of security by the community, and  the development of Defense strategies for the country. For this purpose, the document begins by making a review of the definition of Scientific Diplomacy for Security and National the Defense and continues into highlighting emblematic cases from Colombia, as the central argument into recognizing the great potential this area has for Security and National Defense in the domains of land, sea, air and cyberspace. The scope of the research is descriptive, as its intention is to be a starting point for further analysis on the subject. The problem identified is the lack of recognition of the potential that science diplomacy represents both in terms of competitive advantage for geopolitics and as a contribution to the image of the military forces as an organization whose functions go beyond purely war activities to include important scientific developments. The paper concludes by issuing general recommendations to achieve such recognition.
Principios del derecho internacional: punto de partida para la garantía de los derechos humanos
Authors: Castillo Dussán César Augusto
Published: December 2024

Los principios generales de derecho internacional y los propósitos de la comunidad internacional incorporados en diferentes convenciones internacionales se convierten en directrices para la normatividad jurídica a emplear por los Estados, en cuanto estos contienen valores esenciales para lograr los ideales de convivencia y de justicia; además, sus bases teóricas son fundamentales en el actuar de los sujetos de derecho internacional. Los Estados, en su propósito de hacer efectivas sus políticas internas y su política exterior, deben basar sus actuaciones en esos lineamientos que contienen los principios y los propósitos del derecho internacional. La comunidad internacional organizada destaca su importancia y vigencia para prevenir violaciones a los derechos humanos, para garantizarlos y para evitar quebrantamientos y amenazas a la paz y a la seguridad mundiales. Es fundamental entender la esencia de los principios y utilizarlos bajo parámetros de consensualidad, para que se hagan vigentes y efectivos; de esta manera se podrá superar retos y alcanzar los objetivos pretendidos por los Estados1, reivindicar su obligación de garantizar los derechos humanos y, de cierta forma, procurar por la supervivencia de la humanidad.
Desafíos de la seguridad humana en los nuevos dominios de la guerra
Authors: Cano Cuevas Diego Fernando
Published: December 2024

El presente documento examina los nuevos dominios de la guerra y los desafíos que plantean a la seguridad humana en la era moderna. En particular, se analiza el ciberespacio, las operaciones de información y la militarización del  espacio exterior como dominios emergentes que requieren una atención estratégica y una política adecuada. En primer lugar, se aborda el ciberespacio como un dominio crítico. El crecimiento exponencial de la conectividad digital ha dado lugar a una mayor vulnerabilidad a los ciberataques, arriesgando la seguridad e intimidad de las personas. Proteger los datos de cada persona y la infraestructura digital se vuelve esencial para salvaguardar la seguridad humana. En segundo lugar, se exploran las operaciones de información como un desafío importante. La propagación de desinformación puede disminuir la confianza en las instituciones y generar polarización en la sociedad; por eso, se prioriza enseñar sobre medios y pensamiento crítico para contrarrestar estas amenazas a la seguridad humana. Por último, se analiza la militarización del espacio exterior como un nuevo dominio de guerra: actividades militares en el espacio como la vigilancia y el desarrollo de armas antisatélite plantean riesgos significativos para la seguridad y la estabilidad mundial. La comprensión de estos desafíos y el desarrollo de políticas efectivas son cruciales para proteger la seguridad de las personas y sus derechos. El abordaje integral de estos desafíos es esencial para garantizar el bienestar de cada ser humano en un mundo que cada día depende más de la cibernética y la tecnología.
La consulta previa como derecho de los pueblos indígenas: el caso venezolano en derecho comparado
Authors: Pérez Alvarez Carla
Published: December 2024

Este artículo analiza el cumplimiento del Estado venezolano en cuanto al derecho a la consulta previa de los pueblos indígenas, de acuerdo con los estándares establecidos en el derecho internacional y los convenios asumidos por el Estado en el marco de participación del sistema normativo de las Naciones Unidas. Para ello, se utiliza el método del derecho comparado y se revisan las legislaciones y jurisprudencias de otros países americanos que han reconocido este derecho. Además, se evalúa la situación actual de este derecho en Venezuela, destacando las fallas y violaciones del Estado, especialmente en las zonas afectadas por el Arco Minero del Orinoco. Se concluye que el Estado venezolano no ha respetado este derecho fundamental de los pueblos indígenas.
Problems of Implementation of the Provisions of the Council of Europe Convention on Preventing and Combating Violence Against Women and Domestic Violence in Ukraine’s Legislation
Authors: Bogdanov Roman , Levchenko Kateryna , Legenkyi Mykola , Lehenka Maryna
Published: December 2024

The Council of Europe Convention on Preventing and Combating Violence Against Women and Domestic Violence is an important international instrument aimed at preventing and addressing violence against women and domestic violence. Ukraine, like other signatories of the Convention, continues to encounter basic scientific and practical challenges in implementing its provisions in national legislation in matters relating to domestic violence. This article identifies some of predicaments and impediments affecting the national laws of Ukraine making it difficult in aligning with international prescription. Ukraine continues to face numerous challenges when addressing violence against women and domestic violence, such as awareness and understanding among relevant stakeholders, insufficient funding, resistance from certain sectors of society, and weaknesses in the existing legal framework. The article concludes by suggesting some guidelines for addressing these challenges, such as emphasizing the importance of raising awareness, ensuring adequate funding, engaging with resistant sectors of society, and strengthening the legal framework. Continued efforts are necessary to fully implement the Convention and prevent violence against women and domestic violence in Ukraine.
El impacto de las tecnologías en el proceso judicial: una mirada a partir de los conceptos de juez digital y debido proceso
Authors: Guevara Flórez Lady Juliana , Botero Chica Luis Alfonso , Moreno Mosquera Víctor Julián
Published: December 2024

Se aborda el impacto de tecnologías emergentes como la inteligencia artificial (IA), en el proceso judicial, destacando la visión representativa del “juez digital” y su potencial para transformar la administración de justicia. Mediante un enfoque analítico-descriptivo, enmarcado en un tipo de metodología cualitativa, se examina cómo la integración de la IA incide en la aplicación de los principios fundamentales del derecho y la operatividad del sistema judicial. Se inicia con una discusión sobre la constitucionalización del derecho en la era digital. Así, se puede dar un acercamiento al concepto de juez digital. Finalmente, se aborda el uso del sistema PretorIA en la Corte Constitucional de Colombia. Al determinar que PretorIA corresponde a un tipo representativo de juez digital conocido como “herramientas de soporte para decisiones”, se implica que la IA será meramente un facilitador de la justicia, al ubicar y facilitar al operador judicial información jurídicamente relevante en segundos, gracias a las tecnologías como el big data o las blockchains que permiten una mayor celeridad por parte del sistema judicial. Se comprende, así, cómo en la era digital es importante hacer uso de las nuevas tecnologías, sin desconocer riesgos de ella, como puede suceder con la IA generativa. A través de este análisis, se busca contribuir al debate sobre la configuración de un sistema judicial que respete los principios de justicia, equidad y debido proceso en la era digital.
Desarrollo de una escala de evaluación de actitudes hacia la corrupción en población colombiana (EAC-3)
Authors: Martínez-Rodríguez Tomás , Aycardi Renata , Cortés-Briceño María Juliana , Tovar-Peña Natalia , Riveros Munévar Fernando
Published: December 2024

La corrupción es un problema mundial y tiene efectos en los ámbitos político, económico, social e incluso ambiental. Este fenómeno puede ser ejercido y contemplado por cualquier individuo en diversas situaciones de la vida cotidiana —personal, política, laboral y académica—, hacia las que las personas manifiestan una serie de actitudes, las cuales se requiere evaluar objetivamente. Se desarrolló un estudio empírico y cuantitativo, de tipo psicométrico y de carácter instrumental, con el objetivo de diseñar una escala para medición y evaluación de actitudes hacia la corrupción. Se llevó a cabo una revisión teórica a partir de la cual se construyó una tabla de especificaciones para establecer las dimensiones y el número de ítems pertinentes por cruce; se diseñaron los reactivos, que fueron sometidos a validación por jueces y, tras realizar los ajustes necesarios, la escala se aplicó a 386 adultos colombianos entre 18 y 83 años (M=26,73; DE=13,69). Luego, se adelantó un análisis factorial exploratorio, que agrupó los reactivos en tres factores: actitudes hacia la corrupción propia, actitudes hacia la corrupción ajena y actitudes hacia la corrupción en posiciones de poder. Asimismo, se realizaron análisis de confiabilidad, los cuales mostraron una alta consistencia interna y confiabilidad (alfa de Cronbach= 0,873; GLB= 0,938) y alta validez (varianza explicada del 51,6 %). Por último, se desarrollaron los baremos de calificación. En conclusión, la escala de evaluación de actitudes hacia la corrupción EAC-3 es un instrumento válido, confiable y consistente para su utilización en contexto colombiano, y se recomienda la evaluación de las actitudes hacia la corrupción como un indicador de riesgo hacia dicha conducta.
Methyltransferase like 13 promotes malignant behaviors of bladder cancer cells through targeting PI3K/ATK signaling pathway
Authors: Zhang Jun , He Jiejie , Qiang Ziyang , Zhang Junli , Hao Fengchen , Song Shiqi , Chen Xiuying , Ma Wei , Li Yan
Published: December 2024

Bladder cancer (BC) is the tenth most common tumor worldwide, characterized by high incidence rates and mortality. This study aimed to explore the role of Methyltransferase like 13 (METTL13) in BC cells. J82 and T24 cells were cultured for in vitro experiments. Cell viability, migration, and invasion were assessed using CCK-8 and transwell assays. Senescence-associated beta-galactosidase (SA-β-gal) levels were detected using a β-galactosidase staining kit. METTL13 and cell cycle-related protein levels were quantified using RT-qPCR and Western blotting. The results showed that METTL13 was upregulated in BC cells. Silencing METTL13 decreased cell viability, migration, and invasion in BC cells, whereas METTL13 overexpression increased these parameters. Additionally, METTL13 knockdown inhibited the phosphorylation levels of PI3K, AKT, and mTOR. Inhibition of the PI3K/AKT pathway reversed the effects of METTL13 on cell viability, migration, invasion, and cell cycle-related proteins in BC cells. In vivo experiments showed that METTL13 knockdown inhibited tumor growth and development. In conclusion, this study demonstrated that METTL13 promoted the malignant behaviors of BC cells through activation of the PI3K/AKT signaling pathway. METTL13 may be a promising therapeutic target for BC in the future.
Emotion-Driven Training: Innovating Virtual Reality Environment for Autism Spectrum Disorder Patients
Authors: Abdulbaki Alshirbaji Tamer , Arabian Herag , Igel Marcel , Wagner-Hartl Verena , Moeller Knut
Published: December 2024

Autism Spectrum Disorder (ASD) presents neurodevelopmental challenges in social interaction, communication, and restricted or repetitive patterns of behaviour. Common conditions of ASD may include difficulties in understanding social cues and engaging in conversations. With the spread of virtual and augmented reality technologies, there has been growing interest to develop game-based learning approaches for helping patients and reducing the impact of ASD. Thus, a virtual environment has been developed to be used in a system dedicated for the emotional training of patients with ASD to improve social interaction and develop appropriate emotional responses to real-life scenarios.