bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential of Ethanol Extract of Red Gedi Leaves (Abelmoschus manihot L. Medik) Against Endogenous Antioxidant Activity in Rat Model of Diabetes Mellitus
Authors: Amalia Annora Rizky , Alfina Nurrahman  , Dewi Weni Sari  , Muhammad Firdaus
Published: July 2024

Diabetes mellitus (DM) is characterized by chronic hyperglycemia and increased oxidative stress, contributing to disease complications. Red gedi leaves (Abelmoschus manihot L. Medik) are rich in bioactive compounds, including tannins, saponins, alkaloids and flavonoids, with antioxidant potential. This study aims to evaluate the effect of ethanol extract of red gedi leaves on endogenous antioxidant activity in rat model of DM induced by STZ-NA. Male rats were induced with DM with streptozotocin (STZ)-NA. Rats were divided into five groups: normal control (KN), DM control (KDM), glibenclamide positive control (KPG), and group treated with red gedi leaf extract at a dose of 100 mg/kgBW (GEDI 100), 200 mg/kgBW (GEDI 200), and 400 mg/kgBW (GEDI 400). The parameters observed included blood glucose levels, malondialdehyde (MDA) as a marker of oxidative stress, as well as the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver tissue. Data analysis used one-way ANOVA and Tukey's post hoc test (p<0.05). The results showed that the yield of ethanol extract from red gedi leaves was 6.984%. Administration of red gedi leaf extract at a dose of 400 mg/kgBW (GEDI 400) significantly reduced blood glucose levels (p<0.05) and MDA (p<0.05), and increased the activity of SOD (p<0.05), CAT (p<0.05), and GPx (p<0.05) in DM rats compared to the DM control group (KDM). The effect of GEDI 400 was comparable to the effect of glibenclamide as a positive control. The ethanol extract of red gedi leaves at a dose of 400 mg/kgBW was effective in increasing endogenous antioxidant activity and reducing oxidative stress in STZ-NA-induced DM rats, showing potential as an antioxidant and antidiabetic agent.
Lonicerin Alleviates Interleukin-1β-Stimulated Extracellular Cartilage Matrix Degradation and Inflammation
Authors: Ma Jun , Gong Dong , Chen Xiaotao
Published: July 2024

This study aimed to investigate the effects of lonicerin on an osteoarthritis model in vitro and determine its mechanism of action. We induced SW1353 cells with interleukin-1β to construct a cell model of osteoarthritis. The effects of lonicerin on cell viability were observed using cell counting kit-8 assays. Quantitative polymerase chain reaction, immunoblot, and enzyme-linked immune-sorbent assays revealed the effects of lonicerin on inflammation. Additionally, quantitative polymerase chain reaction and immunoblot assays showed the degree of extracellular matrix degradation. Immunoblot assays were further performed to confirm the mechanism of action of lonicerin. Lonicerin contributed to interleukin-1β-stimulated SW1353 cell viability. Furthermore, lonicerin restrained the inflammatory response of interleukin-1β-stimulated SW1353 cells, suppressed the extracellular matrix degradation of interleukin-1β-stimulated SW1353 cells, and increased collagen II expression. Mechanically, lonicerin suppressed the nuclear factor-kappa B pathway and prevented osteoarthritis progression. Lonicerin alleviates interleukin-1β-stimulated cartilage extracellular matrix and inflammation.
Platycodin D Exerts Anticancer Effects by Promoting Mitochondrial Apoptosis in Laryngeal Squamous Cell Carcinoma
Authors: Kong Meihua , Cai Yanzhi , He Qian
Published: July 2024

Laryngeal squamous cell carcinoma is a challenging malignancy with increasing incidence globally, necessitating the exploration of novel therapeutic strategies. Platycodin D, a saponin derived from Platycodon grandiflorum, has shown promise in cancer therapy, exhibiting anticancer effects in various tumor types. However, the specific mechanisms of action of Platycodin D in laryngeal squamous cell carcinoma remain poorly understood. Therefore, our study aimed to investigate the anticancer effects of Platycodin D in laryngeal squamous cell carcinoma. We revealed that Platycodin D effectively inhibited the proliferation of laryngeal squamous cell carcinoma cells and induced mitochondrial apoptosis. Furthermore, we found that Platycodin D downregulated the expression of S-phase kinase-associated protein 2, indicating a novel target for PD’s action. Finally, the suppression of S-phase kinase-associated protein 2 by Platycodin D led to cell cycle arrest and enhanced apoptosis in laryngeal squamous cell carcinoma cells. Collectively, these findings underscore the potential of Platycodin D as a novel therapeutic agent for laryngeal squamous cell carcinoma, with implications for targeting mitochondrial apoptosis and S-phase kinase-associated protein 2 in cancer treatment.
Edukasi Pemanfaatan TOGA dan Pembuatan Produk Disinfektan serta Balsam Stik Berbahan Dasar Lengkuas
Authors: Ayuningtyas Nurista Dida , Hardy Junius , Pramitaningastuti Anastasia S , Arianditha Pranasti Ernestine , Reni Cyrena Santoso Feronia , Setiawan Benny
Published: July 2024

Background: Batok Village has quite a large agricultural land with the commodity of agricultural products, Alpinia galanga, but the selling value of Alpinia galanga is very cheap. Therefore, the community service team aims to provide education on planting TOGA and making disinfected products and balsam sticks to increase their market value. Methods: Steps taken are observation, preparation, implementation, and evaluation. Results: In the observation, it was observed that Batok Village has agricultural land that is fertile enough for TOGA planting. The preparation process carried out is the manufacture of disinfectant products and balsam sticks with Alpinia galanga as the active ingredient. The Alpinia galanga disinfectant is shown to inhibit the growth of microorganisms, and the resulting balsam stick is solid, easy to apply, produces a warm effect, and does not irritate. Conclusion: The participants were very enthusiastic in participating in the PkM activities, and the results of the evaluation analysis of the participants' knowledge level increased.
Rancang bangun aplikasi penilaian kinerja guru pada SMK PGRI Kasembon Kabupaten Malang
Authors: Muhammad Ilham Saleh  , Sulistiowati  , Tony Soebijono  , Martinus Sony Erstiawan  , Titik Lusiani
Published: July 2024

Salah satu SMK di kabupaten Malang adalah SMK PGRI Kasembon. Jurusan yang dimiliki sekolah ini adalah Akuntansi dan Lembaga Keuangan, Bisnis Daring dan Pemasaran, serta Teknik Komputer dan Jaringan. Saat ini jumlah guru sebanyak 29 guru dan 475 siswa. Komponen agar kualitas sekolah menjadi baik adalah adanya guru yang berkompeten. Hal ini dipantau melalui hasil penilaian kinerja guru sesuai Permendiknas tentang standar kualifikasi dan kompetensi guru. Permasalahannya adalah penilaian kinerja guru di SMK ini masih konvensional dengan pengisian form penilaian kinerja dan pengolahan datanya dengan Excel sehingga membutuhkan waktu lama. Solusi yang diberikan dengan merancang dan membangun Aplikasi penilaian kinerja Guru berbasis website. Aplikasi yang dihasilkan meliputi pengelolaan user, input dan perhitungan nilai sesuai kriteria Permendiknas beserta laporan. Hasil pengujian dengan Black Box testing diperoleh semua fungsi pada aplikasi telah berjalan dengan baik. Sedangkan hasil pengujian User Acceptance Testing (UAT) diperoleh rata-rata sebesar 96,6%, artinya aplikasi sesuai dengan kebutuhan pengguna
Sistem pakar diagnosis gangguan tumbuh kembang balita dengan certainty factor
Authors: Rastio Ajie Meraldy Fiko , Hartanti Dwi , Atina Vihi
Published: July 2024

Perkembangan dunia teknologi informasi dan komunikasi semakin pesat dan merambah ke beberapa sektor salah satunya yaitu dunia kesehatan. Salah satu hal yang dapat membantu di Dunia Kesehatan adalah membuat sesuatu yang dapat berfikir dan bertindak lazimnya manusia yang bisa disebut dengan “Sistem Pakar”. Gangguan tumbuh kembang balita berdampak negatif jangka panjang. Akses terbatas ke fasilitas kesehatan, seperti posyandu yang hanya sebulan sekali dan konsultasi dokter anak yang mahal serta waktu praktek terbatas, meningkatkan kasus gangguan tumbuh kembang pada balita. Dalam bidang ini, sistem pakar berguna dalam mendeteksi gangguan tumbuh kembang pada balita. Sistem pakar ini menggunakan metode certainty factor. Metode certainty factor akan berjalan dari fakta yang diimplementasikan dengan bagian IF dan THEN, kemudian melalui rule-rule yang berisi gejala dan penyakitnya, dan akhirnya menghasilkan diagnosis penyakit. Setelah dilakukan pengujian dengan menggunakan 15 sampel data pasien menunjukkan hasil akurasi sebesar 93%. Sistem pakar ini memungkinkan orang tua pasien mendeteksi gangguan tumbuh kembang balita secara dini dengan cepat, sehingga bisa segera mendapatkan perawatan terpadu dari dokter spesialis
Sistem manajemen gudang untuk UMKM dan pemanfaatan machine learning pada penjualan grosir minuman
Authors: Raisa Nuraffifa Sudardjat  , Vina Sari Yosephine
Published: July 2024

Di era industri 4.0, transformasi digital merupakan hal yang penting untuk meningkatkan fleksibilitas dan efisiensi operasional. Koneksi yang lebih baik dan teknologi seperti Internet of Things, artificial intelligence, dan robotika telah mengubah cara industri memproduksi, mengelola, dan berinteraksi dengan pelanggan. Usaha Mikro, Kecil, dan Menengah kini tengah menghadapi tantangan khusus dalam transformasi tersebut, terutama terkait dengan investasi yang signifikan untuk infrastruktur TI dan kebutuhan tenaga kerja yang mahir dalam keterampilan digital. Hambatan tersebut dapat menghambat adopsi dan integrasi penuh inovasi digital oleh UMKM. Meskipun demikian, transformasi digital sangat berpotensi bagi UMKM, terutama dalam pengembangan aplikasi manajemen gudang yang memanfaatkan teknologi digital. Inovasi tersebut dapat meningkatkan efisiensi secara signifikan dalam pemantauan stok, pelacakan inventory, dan pengelolaan logistik secara real-time, sehingga berdampak pada keberlanjutan bisnis UMKM di era digital. Penelitian ini bertujuan untuk mengembangkan model manajemen gudang yang terdiri dari sistem informasi dan teknologi machine learning yang disesuaikan untuk UMKM. Hasil pengujian laboratorium menunjukkan bahwa sistem ini memiliki tingkat akurasi yang tinggi, sehingga sesuai untuk digunakan oleh UMKM
Pengaruh Kualitas Produk, Harga Dan Promosi Terhadap Keputusan Pembelian Produk Di Toko Ramli Collection Gresik
Authors: Marsha Tsabita Sufi , Aslamiyah Suaibatul
Published: July 2024

The increasingly advanced development of the business world makes competition increasingly fierce, requiring enterpreneurs to analyze what factors influence purchasing decitions. This research aims to determine the influence of product quality, price and promotion on purchasing decisions at the Ramli Collection Gresik store. This research method is descriptive quantitative by obtaining primary data obtained directly from the source using a questionnaire. The population in this research are buyers who have made purchasing decisions about Ramli Collection Gresik products. The sample consisted of 144 respondents selected using the purposive sampling method. Data analysis uses research instrument tests, classical assumption tests, multiple regression analysis, and hypothesis testing. The analytical tool used in this research is SPSS 23. The results of the research show, partially the Product Quality, Price and Promotion have a positive and significant effect on Purchasing Decisions at the Ramli Collection Gresik Store
Pengaruh Fitur Layanan, Kemudahan, dan Keamanan Terhadap Minat Penggunaan Pada Aplikasi E-Wallet XYZ Di Gresik
Authors: Mahmudah Choirotul , Sukaris Sukaris
Published: July 2024

Perkembangan teknologi yang semakin pesat mempengaruhi banyak aktivitas masyarakat, salah satunya yaitu aktivitas dalam bertransaksi. Penelitian ini bertujuan untuk mendapatkan bukti empiris terkait pengaruh fitur layanan, kemudahan, dan keamanan terhadap minat penggunaan pada aplikasi e-wallet XYZ. Penelitian ini merupakan jenis penelitian kuantitatif dengan jumlah sampel sebanyak 150 responden. Data didapatkan melalui kuisioner yang disebar dengan ketentuan konsumen yang berminat atau pernah menggunakan aplikasi XYZ, yang bertempat tinggal di Gresik. Analisis yang digunakan dalam penelitian ini adalah regresi linear berganda yang selanjutnya akan menguji hipotesis. Adapun keterbatasan dalam penelitian ini adalah jumlah responden yang terlibat dalam penelitian ini terbatas, sehingga dapat membatasi representativitas hasil penelitian. Semakin besar ukuran sampel, semakin tinggi validitas dan reliabilitas temuan penelitian. Hal ini dapat mempengaruhi akurasi dan validitas hasil penelitian. Keterbatasan waktu dan sumber daya dapat membatasi dalam melaksanakan penelitian yang lebih komprehensif. Terdapat pembatasan dalam hal pengumpulan data dan analisis yang lebih mendalam. Sedangkan pengembangan penelitian ini kedepannya dapat mempertimbangkan tiga faktor utama, yaitu fitur layanan, kemudahan, dan keamanan. Untuk penelitian yang lebih komprehensif, dapat melibatkan variabel lain seperti presepsi kepercayaan, kepuasan pelanggan, atau faktor psikologis yang mempengaruhi pengunaan, serta memberikan kontribusi yang lebih signifikan dalam bidang penelitian ini.
Computational Techniques for Accurate Solutions of Astrophysical Problems Using Transform-Based Collocation
Authors: Adewumi A. O. , Akindeinde S. O. , Lebelo R. S.
Published: July 2024

This study applies three advanced techniques based on transforms to find approximate solutions to the Lane-Emden type equation, which is often encountered in mathematical physics and astrophysics. The proposed methods utilize new trial functions derived from expressing the second-order derivative of the variable function y(x) using Bernoulli polynomials, and applying Laplace, Sumudu, and differential transforms. To assess the effectiveness of the proposed methods, the study establishes an error analysis and stability analysis, and provides numerical examples demonstrating their accuracy and efficiency. In addition, a comparison of the absolute errors is made among the three methods, namely, Laplace Transform Bernoulli Collocation Method (LTBCM), Sumudu Transform Bernoulli Collocation Method (STBCM), and Differential Transform Bernoulli Collocation Method (DTBCM), and with those obtained from prior literature. The results show that all three methods perform very well in terms of efficiency and accuracy, and can be considered as suitable techniques for solving the Lane-Emden type equation.
Age-Related Features of the Prevalence, Early Diagnosis and Survival of Breast Cancer Patients (Clinical and Population-Based Study)
Authors: Мерабишвили Вахтанг Михайлович , Семиглазов Владимир Фёдорович , Бусько Екатерина Александровна
Published: July 2024

Введение. Рак молочной железы (РМЖ) — ведущая патология заболеваемости женщин злокачественными новообразованиями (ЗНО) в возрастном периоде от 30 до 70 лет. Современные методы ранней диагностики позволяют выявить ЗНО в ранний период его возникновения. Созданная в стране современная информационная система популяционных раковых регистров позволяет получить объективную информацию о состоянии службы. Значительным шагом в развитии надежности получаемых данных явилась организация ракового регистра в Северо-Западном федеральном округе (СЗФО), охватившего около 14 млн населения России, что больше населения Белоруссии, Латвии и Эстонии вместе взятых. Накопленная база данных (БД) составляет более 1,5 млн наблюдений, а главное на ее основе осуществляются расчеты наблюдаемой и относительной выживаемости больных.
Цель. Проанализировать современное состояние онкологической службы России и СЗФО РФ по распространенности РМЖ, ранней диагностике и выживаемость больных с учетом возрастных особенностей отдельно для женского и мужского населения.
Материалы и методы. Материалом исследования являются статистические данные Международного агентства по исследованию рака (МАИР) — XII том монографии «Рак на пяти континентах», справочники МНИОИ им П.А. Герцена и ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России, БД популяционных раковых регистров (ПРР) Санкт-Петербурга и Северо-Западного федерального округа России (СЗФО РФ). Обработка данных осуществлялась с помощью лицензионных программ MS Excel 2013-2016 и STATISTICA 6.1. Для расчета выживаемости использована модифицированная программа Eurocare, а также математические, библиографические и статистические методы.
Результаты. Результаты исследования свидетельствуют, что РМЖ в России и СЗФО РФ имеет средние уровни заболеваемости в пределах 50-60 ‱₀ среди женского населения и 0,4-1,0 ‱₀ среди мужского. С 2000 по 2021 гг. заболеваемость женщин РМЖ возросла в стандартизованных показателях с 38,2 до 50,42 ‱₀. Пандемия коронавирусной инфекции ограничила возможность получения специализированной онкологической помощи почти 9 тыс. больных. В стране активно внедряются новые методы ранней диагностики, в т. ч. цифровая маммография, направленная на своевременное выявление неинвазивного и раннего инвазивного РМЖ. Смертность женщин от РМЖ за 2021 г. снизилась на 27,73 %, мужчин — на 17,65 %. Существенно повысилось качество первичного учёта больных. Наивысшие показатели однолетней выживаемости женщин больных РМЖ регистрировались среди лиц в возрасте от 20 до 69 лет (90 %), среди долгожителей этот показатель составил около 35 %.
Заключение. Проведенное исследование впервые позволило детально исследовать характер повозрастных изменений уровней заболеваемости, смертности, качество учета впервые зарегистрированных больных РМЖ и повозрастную выживаемость, включая долгожителей
TP53 Mutation Type and Platinum-Free Interval in Patients with High-Grade Serous Ovarian Cancer
Authors: Соколенко Анна Петровна , Городнова Татьяна Васильевна , Котив Христина Богдановна , Берлев Игорь Викторович , Имянитов Евгений Наумович
Published: July 2024

Введение. Нарушение функции p53 — это драйверное событие в серозных карциномах яичника высокой степени злокачественности (HGSOC). Существует два основных функциональных типа мутаций TP53: инактивирующие повреждения, которые сопровождаются потерей экспрессии гена (LOF-мутации), и замены, приводящие к появлению новых онкогенных функций p53.
Цель. Изучить, влияет ли тип мутации TP53, а именно аминокислотные замены в ДНК-связывающем домене (DBD) p53 и инактивирующие повреждения, на скорость репопуляции микрометастазов в отсутствие цитотоксического воздействия и, таким образом, на продолжительность бесплатинового интервала (PFI) у пациенток с HGSOC.
Материалы и методы. Продолжительность PFI проанализирована у 60 больных HGSOC III-IV стадии FIGO, которые проходили лечение в ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России в 2017-2023 гг. В исследование включались пациентки с известным статусом мутаций BRCA1/2, которые завершили адъювантный этап платиносодержащей терапии и не имели признаков заболевания на момент окончания лечения. Соматические мутации TP53 определяли методом высокопроизводительного секвенирования.
Результаты. В BRCA1/2-ассоциированных карциномах были обнаружены значимые различия в продолжительности PFI у больных с LOF- и DBD-мутациями TP53 (медианы PFI 55,9 (95 % ДИ 12,5-99,4) и 11,5 (95 % ДИ 3,4-19,6) мес., соответственно (p = 0,04)). Продолжительность PFI > 12 мес. в группе BRCA1/2-ассоциированных раков чаще наблюдалась в случае LOF-мутаций, чем миссенс-мутаций в DBD (10/11 [91 %] vs. 8/17 [47 %], p = 0,04); в спорадических карциномах такое различие обнаружено не было.
Выводы. B BRCA1/2-ассоциированных карциномах яичника тип мутаций TP53 коррелирует с продолжительностью PFI и частотой достижения PFI > 12 мес. Анализ статуса p53 в HGSOC может улучшить возможности персонализированного лечения новообразований этой локализации.
First Experience of Testing for Human Papillomavirus in the Republic of Tajikistan
Authors: Мухсинзода Нилуфар Абдукаххоровна , Баротова Барно Уктамовна , Киёбекова Гулчехра Асадбековна , Турсунов Рустам Абдусамадович
Published: July 2024

Введение. Заболеваемость, распространенность и смертность от рака шейки матки имеет тенденцию устойчивого роста. Всемирная организация здравоохранения приняла глобальную стратегию по элиминации рака шейки матки на период до 2030 г. Начиная с 2020 г. для раннего выявления цервикальной интраэпителиальной неоплазии система здравоохранения Республики Таджикистан внедрила визуальный скрининг на национальном уровне. Тестирование вируса папилломы человека (ВПЧ) в период активного внедрения визуального скрининга в связи с ограниченными ресурсами отнесен в качестве дополнительного теста с перспективой его более широкого применения для ВИЧ-инфицированных женщин и на городское население по мере доступности средств.
Цель исследования. Изучение наиболее распространенных канцерогенных типов вируса папилломы человека среди инфицированных женщин Таджикистана по данным обращений по поводу цервикальной интраэпителиальной неоплазии шейки матки.
Материалы и методы. В исследовании приняли участие 2 лаборатории страны, которые наладили систему забора, транспортировки и направления пациенток с доступом во всех регионах республики. Всего за период с 2017 г. по 2023 г. (6 лет) в обоих лабораториях выполнено 304990 ВПЧ тестов.
Результаты. Самым распространенным ВПЧ канцерогенного типа оказался 16 тип (в 23,3% наблюдений), в пять основных наиболее часто встречаемые типа вошли 18, 31, 39, 53 и 66 типы. В отличие от литературных данных 52 и 58 типы также были обнаружены, но по частоте шли после первых 5 типов ВПЧ.    
Выводы. Первый опыт внедрения в систему диагностики ВПЧ тестирования для выявления предраковых и раковых заболеваний шейки матки является перспективным направлением. Пока получены общие данные о циркулировании онкогенных вирусов в стране. Данное исследование является основой для дальнейшего интегрирования ВПЧ тестирования в систему скрининга и диагностики РШМ в стране.
Knowledge, Attitude and Practice towards E-learning among Medical Undergraduate Students in a Medical College of Maharashtra
Authors: Oshin Agrawal  , Aastha N Pandey  , Akhil Bhalla
Published: July 2024

Introduction: E-learning is a new and quickly adapting means of learning among newer generation studentsas well as faculties. Aim & Objectives: To assess Knowledge, Attitude and Practicest owards e-learning methods to improve clinical and theoretica lskills amongst medical undergraduates and its incorporation in further medical education. Methods: In this cross-sectional study, we evaluated the conceptof e-learningamong undergraduate medical students of different socio-economic and demographic backgrounds.30 students fromeach MBBS batchwere chosen by stratified random sampling and a questionnaire having both open (3) andclose (23) ended questions regardinge-learningmethodswhichwereﬁlled by these students. Results: Total of 135 undergraduate medical students included, among them 55(40.7%) were males, 78 (57.8%) were females. Majority were aware of e-learning. About 88% of them had access to internet and 79.3% had personal computers or laptops. About 90.4% believed e-learning is innovative and shall be encouraged but at the same time 51.9% were afraid if employment would be tough or not. Conclusions: Majority felt that e-learning plays an important role in acquiring clinical skills along with other learning methods in educational institutes. So, there is a need to provide necessary infrastructure and include e-learning as a part of curriculum in medical education
A family of Pseudohypoparathyroidism: report on a family with affected three members
Authors: Antara Das  , Kausik Goswami  , Avik Ghoshal  , Soumita Roy  , Sk Rafikul Rahaman  , Sukanta Sen
Published: July 2024

Pseudohypoparathyroidism (PHP) represents a group of disorders due to end organ resistance to the actions of parathyroid hormone (PTH) and abnormalities in the PTH signalling pathway. PHP is characterized by hypocalcaemia and hyperphosphataemia, with or without a variable expression of physical features. The constellations of these physical features together are termed Albright hereditary osteodystrophy (AHO). PHP and related disorders are primarily clinical diagnoses in our setting as confirmatory laboratory testing is not widely available. Molecular genetics is the gold standard for confirmation and categorization of PHP into the different subtypes, but with recent advances in molecular diagnostics a pathophysiological approach appears to be more practical in the clinical setting. We present here the clinical course of a family of Pseudohypoparathyroidism who have been followed up at Paediatric Department of our hospital.  The cases responded well with calcium and calcitriol supplementation without access to genetic testing in our hospital.
Socio-demographic correlates and association between level of tobacco intake and severity of depression
Authors: Akansha Bhardwaj  , Rashmi Prakash  , Shafaq Raza  , Dimple Gupta  , Nimmi A Jose  , RC Jiloha
Published: July 2024

Background and Aim: Despite decades of research on co-occurring smoking and depression, cessation rates remain consistently lower for depressed smokers than for smokers in the general population, highlighting the need for theory-driven models of smoking and depression. This paper provides a systematic review with a particular focus on psychological states that disproportionately motivate smoking in depression, and frame an incentive learning theory account of smoking-depression co-occurrence. The objective of the study was to estimate the socio-demographic correlates of tobacco consumption and its association with depression.
 
Methodology: This is a cross sectional study.Over a period of one year around 120 depressed and tobacco dependent patients of age group 15 to 80 years were sampled from a tertiary care hospital in this study. Data on tobacco consumption and pattern was elicited from patients and household informants.Prevalence and socio- demographic profile of tobacco dependent depressed patients were used as outcome measures. Association between level of nicotine dependence and severity of depression was also assessed.
 
Results: It was observed that such patients were more associated with the male gender (Females; N=5<Male; N=115), with middle aged group, illiterate, lower middle socio-economic status. Alcohol intake (dependence and harmful use) was more common than other substance intake. In addition to this, there were greater number of depressed patients who had been taking tobacco for more than 10 years. N=66; (55%). They were more likely to use chewable form than smoking alone. N=56(46.7%) The results of HAMD revealed that more nicotine dependence were associated with the severe depression. N=35; (31.7%) It was also found that more number of depressed patients were associated with the moderate/severe dependence on nicotine N=59(49.2%) which was statistically significant. (p=0.001) Tobacco consumption was higher in poor, less educated populations.
Conclusion: The findings of the study highlight that higher nicotine dependence is associated with male smokers, low socio-economic status and low education and the moderate/severe level of depression.
Treatment Outcome of Category I Tuberculosis Patients under RNTCP in a Tuberculosis Unit of Ahmedabad Muncipal Corporation
Authors: Mansuri Sohil ,   GMERS Medical College Panchmahal-Godhra,Gujarat., Jain Shikha , Malek Rahima , Chaudhari Ashish kumar , Bhabhor Hitesh , Devalia Nishitkumar Chandrakantbhai ,   B.J. Medical college, Ahmedabad Gujarat.,   N.D.Desai Medical College, Nadiyad ,Gujarat.,   GMERS Medical College, Navsari, Gujarat.,   GMERS Medical College, Navsari, Gujarat.,   Government Medical College, Surat.
Published: July 2024

Background & Objectives: This study was aimed to know the treatment outcome of category I tuberculosis patients under RNTCP in a tuberculosis unit of Ahmedabad Municipal Corporation. Method: It was a longitudinal (follow up) study conducted from January 2014 to 0ctober 2014 in Rakhiyal tuberculosis unit in Ahmadabad city. Total187 patients of category I were studied. Data was collected using predesigned questionnaire by interviewing the patients thrice (1st visit on base line data second after completion of intensive phase and third after completion of continuation phase. Verbal consent was taken). Tools of study: Pre-designed questionnaire was prepared before study and two follow up visit were done at end of intensive phase first visit(at end of two month) and second at the end of continue phase (at end of six month). During study first of all basic demography profile was collected and verbal consent was taken from all patients and then all the participants were enrolled in this study. Result: The majority of study population was in reproductive age group (67.52%).The ratio of Pulmonary: Extra-pulmonary was 1.3:1.Almost half (48.12%) patients were new sputum smear positive (NSP), (43.32%) New extra-pulmonary and (8.56%) were new sputum smear negative. NSP (New sputum positive): NSN(New sputum negative) ratio was 5.6:1.In majority of patients (61.18%) DOTS was provided by TB Health workers. Sputum conversation rate was (75.56%) after two months. Majority (88.3%) completed the continuous phase. HIV coinfection was found 5.88%. Interpretation and conclusion: Study result showed that all the patients took treatment under the supervision whether in the presence of Community DOTS providers or Private practitioners and all the patients completed the intensive phase of the therapy. This reflects the responsible functioning of the healthcare providers to achieve the primary aim of the tuberculosis programme, which is to detect and cure infectious tuberculosis cases in order to reduce the transmission, morbidity and mortality. Overall sputum conversion rate (75.56%) which was low. The outcome indicates well within acceptable presence of RNTCP which reflect deep programme is being effectively implemented in Tuberculosis Unit. Increased switch over to MDR (4.81%) found in the study could be explained by HIV-TB co-infection and Diabetes.
A Study on Rifampicin Resistant Mycobacterium Tuberculosis in a Tertiary Care Hospital Setting in Mysuru, India
Authors: RanjithaShankare Gowda  , Jul Hassina Ahmed  , Vidyavathi B Chittaragi  , Krishna Karthik
Published: July 2024

ABSTRACT: Tuberculosis (TB) remains one of the commonest infectious diseases in India, where control is difficult due to the emergence of multi-drug-resistant TB (MDR-TB). The rifampicin resistance (RR) is an important surrogate marker of MDR-TB. With increasing use of Xpert MTB/RIF a point of care molecular test for simultaneous detection of TB and resistance to rifampicin, a growing number of rifampicin resistant cases are being detected and notified.  Traditional DST, on the other hand, is time-consuming, and there are significant issues with test consistency and drug stability in various culture media. The late detection of medication resistance could be a crucial factor in MDR-TB transmission. As a result, quick diagnostic assays are essential for efficient drug-resistant tuberculosis control.  Hence the current study was aimed in determining the rate of rifampicin resistance in sputum smear positive cases by drug susceptibility testing (DST) using Lowenstein Jensen media (Proportion method) and comparing these results with that of CBNAAT results.
Betondeckensanierung am ehemaligen Zentralflughafen Berlin Tempelhof/Renovation of the Concrete Ceiling at the Former Airport Berlin Tempelhof
Authors: Berger Jan , Schmidt Jan , Ciupack Yvonne
Published: July 2024

Bei der Instandsetzung historischer Stahlbetondecken am Flughafen Berlin Tempelhof erfolgen herausfordernde Planungs- und Bauleistungen, welche umfassende Voruntersuchungen am Bestand, Vorgaben des Denkmalschutzes und örtliche Besonderheiten im Kontext mit geltenden Normen berücksichtigen. Die Hangardecken werden für höhere Nutzlasten verstärkt und einer neuen Restnutzungsdauer zugeführt.

 

Für die Bemessung der mit bewehrtem Spritzbeton verstärkten Stahlbetondecken wurden durch Voruntersuchungen Schädigungsgrad, Werkstoffeigenschaften und Bewehrung auf etwa 9 260 m² Fläche analysiert. Im Folgenden werden die Ansätze der Nachweisführung für die filigrane Verstärkung vorgestellt. Für die Bauzustände werden modulare Abstützungen eingesetzt, um den Ausfall der unteren Bewehrungsebene auszugleichen und Verformungen zu minimieren. Die Betonoberfläche der in über 20 m Höhe über dem Hangarboden liegenden Decken wird durch Hochdruckwasserstrahlen vorbereitet, mit nicht rostender Bewehrung verstärkt und mit Spritzbeton reprofiliert. Dabei wird die historische Dicke der Stahlbetondecke von 18 cm nur geringfügig erhöht. Die Nachahmung der historischer Brettschalung schließt die Arbeiten ab.
La langue facteur d’identité : le cas des quartiers populaires, zones de relégation, en France
Authors: Goudaillier Jean-Pierre
Published: July 2024

In various places of relegation that exist in France, whether in the suburbs or in overseas territories, the role of language practices based on French or other languages as factors constituting speakers’ identity or various identities (spatial, sociological, socio-economic, cultural, etc.) has to be taken into consideration in order to understand how these identities emerge. In the case of suburbs, language behaviours based on the so-called Français Contemporain des Cités (FCC) and vernaculars related to immigration have to be considered as genuine acts of identity, as confirmed by the following statement: "....young people identify with this mode of expression... it’s something that’s very much their own, they find themselves in it", Ali Ibrahima of Groupe B-Vice, talking about the language spoken by young people of La Savine, a district to the north of Marseille (Canal+ ("La Grande Famille" programme), 24 January 1996). This is just one example of the use of language to assert identity.
Construction et reconstruction de l’identité « périphérique » : analyse des stratégies de la traduction en turc par Ebru Erbaş du français contemporain des cités dans le roman Grand frère de Mahir Güven
Authors: Dağtekin Gülseren Şen
Published: July 2024

This paper examines translation strategies through an analysis of a corpus of words and relevant examples in Mahir Guven’s novel Grand frère’s translation. It recalls the main characteristics of the Urban Youth Slang and emphasizes the significant role this variant of French plays in the novel. After defining the methodology for analyzing the translation strategies, we evaluate the results of the statistical analysis with concrete examples. The paper concludes with the overall effect of translation strategies on the process of recreating the peripheral identity of the narrators.
Guillaume Métayer (dir.), « Francophonies hongroises au féminin : traversées littéraires et sociales (XIXe-XXIe siècles) », Francofonia, no 83, automne 2022, 132.
Authors: Tóth Eszter
Published: July 2024

« Poser la question des voix francophones originaires de Hongrie – sans que le français soit forcément un choix, Agota Kristof et Katalin Molnár y insistent, tout comme d’une autre manière Nina Yargekov –, c’était s’interroger de manière ouverte à la fois sur la géopolitique des langues et des littératures implicites des écrivains […] » (Métayer, 2022 : 6). C’est ainsi que Guillaume Métayer présente la visée de cet ouvrage réalisé sous sa direction. Ce numéro ayant comme thème les écrivaines translingues hongrois-français, propose quatre études et trois interviews d’écrivaines francophones de Hongrie accompagnées d’un texte court d’Itóka Bölöni, de comptes rendus et de notes de lecture.
The Method of Building a Wide Span Structure at Gelora Bung Karno Aquatic Stadium
Authors: Yolanda Azhar Susanti  , Dewi Rachmaniatus  , Tika Novis Putri
Published: July 2024

According to the results and obervation, in the first construction in 1960, the Aquatic Stadium Gelora Bung Karno (GBK) with an area 24,000 m². GBK Aquatic Stadium is an international outdoor building that was inaugurated directly by the first president of Indonesia at that time Soekarno and Hatta, which had 4 swimming pools, namely competition pool, diving pool, water polo pool and training pool. GBK Aquatic Stadium was first designed by well-known architect Federick Silaban, which was later renovated in 2017 by architect Andra Matin, this renovation is because there must be conformity of the international stadium by following international swimming standards, namely the Federation Internationale de Natation (FINA) which one of the standards is indoor, the potential of the indoor stadium is related to the impact of the weather in Indonesia which is uncertain. In addition, the reason for renovating the GBK Aquatic Stadium is because there is a major event, namely is Asian Games which was held in Indonesia in 2018. The result of the renovation of Andra Matin is only on the roof. In accordance with the government's appeal at was, GBK Aquatic Stadium was a historic building, where the government did not allow any changes to the initial design of the stadium, Andra Matin also made new columns outside GBK Aquatic Stadium building as a support for the new roof. Andra Matin designed the roof of GBK Aquatic Stadium with a space frame wide span structure system, by applying form of fluidity or form of water properties. There are 5 waves on the right side, and flat on the roof on the left. According to Andra Matin, the water was exposed to the waves then calmed down. Since the renovation and Asian Games 2018, this area has attracted the attention of many people because of its unique building.
Uso de la Educación Financiera en la Microempresa, Análisis en Algunas Regiones de Chimborazo
Authors: Nieto Dorado Wuilian Franklin , Alvarado Buñay Johanna Carolina , Arteaga Verdezoto María Elena , Mendoza Pala María del Carmen
Published: July 2024

En la micro empresa de hoy, la educación financiera aborda procesos instructivos relacionados con el manejo económico y la toma de decisiones tornándose una necesidad permanente. El objetivo general de este artículo es aplicar encuestas a varios microempresarios para saber el uso de la educación financiera en el desarrollo de sus actividades económicas. Se aplicó 321 encuestas a varios microempresarios en algunas zonas urbanas de los diez cantones de la provincia de Chimborazo – Ecuador. La recopilación de datos se realizó por medio de la aplicación de los métodos empíricos, encontrándose dificultades en: el manejo del presupuesto, ahorros, crédito, planificación del retiro laboral, seguridad.  Los resultados se presentan mediante gráficos estadísticos.
La Gamificación como Estrategia Pedagógica en la Educación Matemática
Authors: Bernal Párraga Augusto Paolo , Haro Cedeño Elizabeth Leopoldina , Reyes Amores Carla Geovana , Arequipa Molina Alexander Damian , Zamora Batioja Iris Johanna , Sandoval Lloacana Marcia Yolanda , Campoverde Duran Veronica Del Rocio
Published: July 2024

Este artículo examina la gamificación como estrategia pedagógica en la educación matemática, explorando su impacto en el aprendizaje y la motivación de los estudiantes. La gamificación, que implica el uso de elementos de juego en contextos educativos, se ha convertido en una herramienta prometedora para abordar desafíos en la enseñanza de matemáticas, un área a menudo percibida como difícil y poco atractiva por los estudiantes. A través de un enfoque mixto que combina métodos cualitativos y cuantitativos, este estudio analiza cómo la integración de mecánicas de juego, tales como recompensas, niveles y desafíos, puede mejorar la comprensión conceptual y la participación activa en el aula de matemáticas. Los datos fueron recolectados mediante encuestas, entrevistas y observaciones en varias escuelas de educación básica, involucrando a estudiantes y docentes. Los resultados indican que la gamificación no solo aumenta la motivación y el compromiso de los estudiantes, sino que también facilita un aprendizaje más profundo y significativo. Se identificaron mejoras significativas en la resolución de problemas y en la actitud hacia las matemáticas, destacando la importancia de un diseño cuidadoso y contextualizado de las actividades gamificadas. Además, el estudio aborda los desafíos y limitaciones asociados con la implementación de la gamificación, tales como la necesidad de formación docente específica y la adaptación de recursos tecnológicos. Las implicaciones de estos hallazgos sugieren que la gamificación, cuando se implementa de manera efectiva, puede transformar la educación matemática, haciéndola más accesible y atractiva para los estudiantes. La gamificación ofrece un entorno seguro para la exploración y el ensayo, permitiendo a los estudiantes aprender de sus errores sin temor a la evaluación negativa. Este artículo concluye con recomendaciones prácticas para docentes y formuladores de políticas educativas, enfatizando la necesidad de un apoyo institucional robusto y formación continua para los docentes en el uso de técnicas de gamificación. También se proponen áreas para futuras investigaciones, con el objetivo de optimizar el uso de la gamificación en el aula y mejorar los resultados educativos en matemáticas. La integración de tecnologías educativas y la creación de recursos adaptativos son esenciales para maximizar el potencial de la gamificación en la educación matemática, promoviendo una educación más inclusiva y efectiva.
Current and suitable habitat of the Critically endangered Northern white-cheeked gibbon (Nomascus leucogenys) in Lao PDR
Authors: Phommexay Phansamai , Chaiyes Aingorn , Duengkae Prateep , Chuaynkern Chantip , Chuaynkern Yodchaiy
Published: July 2024

The northern white-cheeked gibbon (Nomascus leucogenys) is native species of Southeast Asia, found in Laos, Vietnam, and China. N. leucogenys is critically endangered on the IUCN Red List. This study aimed to evaluate and predict its potential distribution within Laos under current climate conditions (2022) and future scenarios for 2050 and 2070 using a species distribution modeling software. The study confirmed the presence of N. leucogenys by analyzing color patterns and call structures. Males have less reddish cheeks, a brownish chest patch, and mostly black fur with silver strands, except for pale cheek tufts. Females have a buff face-ring, creamy fur without dark underparts, and a dark brown crown patch with white facial hair. In terms of their calls, the duration of the great call is 14.10 ms, the maximum frequency is 2.260 kHz, and there are 13.00 pulses per great call. Solos last 6.80 ms with a maximum frequency of 1.420 kHz. Duet calls last 21.80 ms. The climate change significantly influences the potential distribution of N. leucogenys. The species distribution models (SDMs) suggest that the highest suited habitat for the 2070 scenario is 734.2 km², which is 0.3% of Laos PDR. This is followed by 2050 with 638.8 km² (0.2%), and 2022 with 236.93 km² (0.1%). These suitability assessments are affected by BIO 18 (23.5%, 29.4%, 38.8%), BIO 2 (15.5%, 12.9%, 12.6%), and river (15.2%, 11.9%, 9.7%). The results identified key considerations for conservation and future monitoring research, including three classes of habitat suitability: highly suitable, moderately suitable, and marginally suitable. These areas encompass approximately 1,397.3 km2 in 2022 (0.6% of Lao PDR), 2,752.8 km² in 2050 (1.2% of Lao PDR) and 3,026 km² in 2070 (1.3% of Lao PDR). These findings provide crucial baseline information for Laotian authorities to develop and implement an effective conservation action plan for N. leucogenys.
Global Neoliberal Capitalism and the Alternatives
Authors: Lane David ,   Emmanuel College, University of Cambridge
Published: July 2024

The paper describes the main features of neoliberalism, its benefits and drawbacks, and the reasons why it should be replaced. The author’s arguments are based on a study of the strengths and weaknesses of neoliberalism. He reveals the reasons behind its popularity and identifies its main shortcomings and ways to eliminate it. The fundamental question of this study is an attempt to find a viable alternative to the neoliberal agenda and possible ways of its practical implementation in the foreseeable future. The latter requires redefining a space for alternative political and economic forms of a developed industrial society, including looking through a prism of the concept proposed by Professor S.D. Bodrunov’s: a transition to reindustrialization, greater social solidarity based on state forms of economic coordination. The paper makes a valuable contribution to the discussion by proposing a hybrid form of regulated market socialism that could be adopted by the national economies of Russia, the United States and Western Europe.
New Products and Needs in the Era of Cyber-Physical Systems
Authors: Skokov Roman Yu. ,   Volga Institute of Economics
Published: July 2024

The article reveals the periodization of the evolution of the main scientific and industrial discoveries in the field of digitalization, artificial intelligence, cyberphysics, as well as the prospects for the evolution of needs and product markets in connection with the development of cyber-physical systems. For cyberphysical systems, there is already an extensive knowledge base formed by various technical disciplines, including information systems, engineering, computer science, and mechanotronics. Neurotechnological companies aim to create a holistic brain interface capable of linking biological and artificial intelligence more closely. The neural interface is able to absolutely determine consumer behavior in accordance with the project. He will be able to set, set consumer behavior in a range in accordance with management goals – from absolutely rational to irrational. The range of applications of cyber-physical systems includes transport, logistics, medical devices, energy, security systems, asset and resource management, distributed robotics, military systems and many others. The products of the future are a computer program that simulates the work of the mind; physical media for storing information; means of extracting and transferring information located in the brain to a computer; quantum computers; controlling machines with the power of thought; exchange of information between people without additional “physical” control interfaces.
Digital Transformation as a Trend of Promotion Towards Noonomy: Marketing Approach
Authors: Yanenko Marina B. ,   Peter the Great St. Petersburg Polytechnic University, Yanenko Mikhail E. ,   S.M. Kirov Saint Petersburg State Forestry University
Published: July 2024

An analysis of the influence of digital transformation on the progress towards noonomy is carried out. Based on the marketing approach, it is shown that digital technologies play a key role in interaction with consumers, allow the creation of new values, markets for goods and services, and change approaches to organizing distribution and delivery systems. It has been established that in the digital marketing complex an important place is given to the digital image of a product. Features of pricing policy are associated with the need to take into account two components – value in the real world, as well as the value of digital products and services in the virtual world. The development of electronic trading platforms, marketplaces, and digital business platforms has led to the emergence of a platform economy. Recommendations for improving competitive strategies in the context of the transition to noonomy are formulated. Considering the complexity and versatility of the impact of digital transformation on the business environment, directions for future research in the field of marketing approaches in noonomy are discussed.