bluuebunny/crossref_metadata_2025 huggingface dataset:
Roman Infrastructure in Early Medieval Britain
Authors: Fafinski Mateusz
Published: April 2021

Early Medieval Britain is more Roman than we think. The Roman Empire left vast infrastructural resources on the island. These resources lay buried not only in dirt and soil, but also in texts, laws, chronicles - even charters, churches, and landscapes. This book uncovers them and shows how they shaped Early Medieval Britain. Infrastructure, material and symbolic, can work in ways that are not immediately obvious and exert an influence long after the builders have gone. Infrastructure can also rest dormant and be reactivated with a changed function, role and appearance. This is not a simple story of continuity and discontinuity: it is a story of transformation, of how the Roman infrastructural past was used and re-used, and also how it influenced the later societies of Britain.
Medina Gounass: Constructing Extra-National Space in a West African Borderland
Authors: Glovsky David Newman
Published: April 2021

The historical autonomy of the religious community of Medina Gounass in Senegal represents an alternative geographic territory to that of colonial and postcolonial states. The borderland location of Medina Gounass allowed the town to detach itself from colonial and independent Senegal, creating parallel governmental structures and imposing a particular interpretation of Islamic law. While in certain facets this autonomy was limited, the community was able to distance itself through immigration, cross-border religious ties, and smuggling. Glovsky’s analysis of the history of Medina Gounass offers a case study for the multiplicity of geographical and territorial entities in colonial and postcolonial Africa.
Dynamical Borel–Cantelli lemma for recurrence theory
Authors: HUSSAIN MUMTAZ , LI BING , SIMMONS DAVID , WANG BAOWEI
Published: April 2021

We study the dynamical Borel–Cantelli lemma for recurrence sets in a measure-preserving dynamical system
$(X, \mu , T)$
with a compatible metric d. We prove that under some regularity conditions, the
$\mu $
-measure of the following set
$$\begin{align*}R(\psi)= \{x\in X : d(T^n x, x) < \psi(n)\ \text{for infinitely many}\ n\in\mathbb{N} \} \end{align*}$$
obeys a zero–full law according to the convergence or divergence of a certain series, where
$\psi :\mathbb {N}\to \mathbb {R}^+$
. The applications of our main theorem include the Gauss map,
$\beta $
-transformation and homogeneous self-similar sets.
Quasimaps and stable pairs
Authors: Liu Henry
Published: April 2021

We prove an equivalence between the Bryan-Steinberg theory of$\pi $-stable pairs on$Y = \mathcal {A}_{m-1} \times \mathbb {C}$and the theory of quasimaps to$X = \text{Hilb}(\mathcal {A}_{m-1})$, in the form of an equality of K-theoretic equivariant vertices. In particular, the combinatorics of both vertices are described explicitly via box counting. Then we apply the equivalence to study the implications for sheaf-counting theories onYarising from 3D mirror symmetry for quasimaps toX, including the Donaldson-Thomas crepant resolution conjecture.
Consumer Stigma and the Reputation Trap Hypothesis: An In-Store Experiment with Colorado Wines
Authors: Costanigro Marco , Jablonski Becca B.R.
Published: April 2021

We conducted an in-store experiment to test the hypothesis that Colorado wines may suffer from reputational stigma. The context relates to marketing challenges faced by novel wine regions entering the competitive retail environment, even in a local context, and the possibility of being stuck in a “bad reputation trap.” Adopting a 2×2 design where we varied region of production (Colorado vs. California) and grape variety (familiar vs. unfamiliar), we administered a between-subject information treatment that revealed the origin of production to only half of the participants. We measured taste perceptions using Likert scales, and we elicited valuation via a multiple price listing. Our results are consistent with the presence of stigma against wines produced in Colorado. In the discussion, we draw from the literature on stigmatized markets to suggest plausible strategies to remove or avoid stigma. (JEL Classifications: L1, L15, Q1, Q13)
From “notable Syrians” to “ordinary Anatolians”: the politics of “normalization” and the experience of exile during World War I
Authors: Çiçek M. Talha
Published: April 2021

This article examines an important attempt at the political engineering undertaken in Syria during the Great War. It focuses on the experience of the Arabs exiled to Anatolia by Cemal Pasha to redesign Syrian society in line with the Committee of Union and Progress’ idea of empire, which imagined an authoritarian regime. The members of the Arabist parties were removed from Syria to eliminate their contemporaneous and future resistance to the emerging despotic regime. The article sets out to analyze what the exiles experienced in Anatolia using their memoirs in Arabic and the Ottoman documents describing their conditions in Anatolia, and to what extent the aims could be realized. It argues that the purpose was to put a politics of “normalization” into practice by depoliticizing the Arab notable families through “relocation” to Anatolia, although the resistance of the exiles and varying attitudes in Ottoman bureaucracy significantly differentiated outcomes. It also uncovers many untold stories with regard to the daily life of the exiles and adds much to our knowledge on the experience of Arab exiles in Anatolia. It is the first serious examination of the experiences of the Arab exiles using their own texts and narrative.
Increasing Precision without Altering Treatment Effects: Repeated Measures Designs in Survey Experiments
Authors: CLIFFORD SCOTT , SHEAGLEY GEOFFREY , PISTON SPENCER
Published: April 2021

The use of survey experiments has surged in political science. The most common design is the between-subjects design in which the outcome is only measured posttreatment. This design relies heavily on recruiting a large number of subjects to precisely estimate treatment effects. Alternative designs that involve repeated measurements of the dependent variable promise greater precision, but they are rarely used out of fears that these designs will yield different results than a standard design (e.g., due to consistency pressures). Across six studies, we assess this conventional wisdom by testing experimental designs against each other. Contrary to common fears, repeated measures designs tend to yield the same results as more common designs while substantially increasing precision. These designs also offer new insights into treatment effect size and heterogeneity. We conclude by encouraging researchers to adopt repeated measures designs and providing guidelines for when and how to use them.
KSBA compactification of the moduli space of K3 surfaces with a purely non-symplectic automorphism of order four
Authors: Moon Han-Bom , Schaffler Luca
Published: April 2021

We describe a compactification by KSBA stable pairs of the five-dimensional moduli space of K3 surfaces with a purely non-symplectic automorphism of order four and$U(2)\oplus D_4^{\oplus 2}$lattice polarization. These K3 surfaces can be realized as the minimal resolution of the double cover of$\mathbb {P}^{1}\times \mathbb {P}^{1}$branched along a specific$(4,\,4)$curve. We show that, up to a finite group action, this stable pairs compactification is isomorphic to Kirwan's partial desingularization of the GIT quotient$(\mathbb {P}^{1})^{8}{/\!/}\mathrm {SL}_2$with the symmetric linearization.
Taxes, Wagenburgs and a Nightingale: The Imperial Abbey of Ellwangen and the Hussite Wars, 1427–1435
Authors: WHELAN MARK
Published: April 2021

Drawing upon unpublished financial accounts, this article sheds new light on how an ecclesiastical institution in southern Germany navigated the tense military and political environment of the Holy Roman Empire during the Hussite wars. The accounts of Ellwangen Abbey offer a compelling window into how its community dealt with a series of military, economic and diplomatic challenges – from raising extraordinary war taxes and hosting the visiting emperor-elect, to equipping its own military contingent – encouraging a reassessment of the burdens borne by ecclesiastical foundations during the Hussite era and offering new perspectives on how holy war impacted on daily life in smaller communities in Central Europe.
Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study
Authors: Ocak E , Mulazimoglu S , Kocaoz D , Mirici E , Dagli E , Acar A
Published: April 2021

Objective

To investigate the effects of nasal irrigation with sodium hyaluronate and surfactant solutions on mucociliary clearance time in patients with mild persistent allergic rhinitis.

Methods

A total of 120 patients diagnosed with mild persistent allergic rhinitis were enrolled in this prospective study. The patients were allocated randomly to the surfactant, sodium hyaluronate or isotonic saline (as a control) nasal irrigation group. The mucociliary clearance times and improvements in mucociliary clearance times were compared.

Results

Improvements in mean mucociliary clearance time were significantly greater in the surfactant and sodium hyaluronate groups than in the control group (p < 0.01). The mean post-treatment mucociliary clearance time of the surfactant group was significantly lower than that of the control (p < 0.001) and sodium hyaluronate groups (p = 0.03).

Conclusion

Surfactant and sodium hyaluronate nasal irrigation solutions may both be used as adjunctive treatments for allergic rhinitis. Surfactant nasal irrigation resulted in better mucociliary clearance times.
Radiological measurement of cochlear dimensions in cochlear hypoplasia and its effect on cochlear implant selection
Authors: Pamuk G , Pamuk A E , Akgöz A , Bajin M D , Özgen B , Sennaroğlu L
Published: April 2021

Objective

To determine the effect of cochlear dimensions on cochlear implant selection in cochlear hypoplasia patients.

Methods

Temporal bone computed tomography images of 36 patients diagnosed with cochlear hypoplasia between 2010 and 2016 were retrospectively reviewed and compared with those of 40 controls without sensorineural hearing loss.

Results

Basal turn length and mid-modiolar height were significantly lower in the cochlear hypoplasia patients with subtypes I, II and III than in the control group (p < 0.001). Mid-scalar length was significantly shorter in subtype I–III patients as compared with the control group (p < 0.001). In addition, cochlear canal length (measured along the lateral wall) was significantly shorter in subtype I–IV patients than in the control group (subtypes I–III, p < 0.001; subtype IV, p = 0.002)

Conclusion

Cochlear hypoplasia should be considered if basal turn length is less than 7.5 mm and mid-modiolar height is less than 3.42 mm. The cochlear implant should be selected according to cochlear hypoplasia subgroup. It is critically important to differentiate subtype II from incomplete partition type I and subtype III from a normal cochlea, to ensure the most appropriate implant electrode selection so as to optimise cochlear implantation outcomes.
The intonation of yes–no questions in Luganda
Authors: Myers Scott
Published: April 2021

The intonation of yes–no questions in Luganda (Bantu, Uganda) has only been sketched in passing. Hyman states that Luganda yes–no questions are marked by a ‘super-high tone’ immediately following the last lexical high tone in the sentence, but there is little agreement in the literature about the intonation of yes–no questions if there is no lexical high tone in the sentence. To clarify the differences between statements and yes–no questions in Luganda, an acoustic production study was conducted. Nineteen speakers read aloud sentences differing in the location of the last lexical high tone relative to the end of the sentence. Each sentence was produced as a statement and as a question. Analysis of f0 measurements supported Hyman’s description of sentences with a lexical high tone, since the questions had an f0 peak that was higher and later than in the corresponding statements. For sentences without a lexical high tone, yes–no questions were found to begin with an interval in which f0 is higher than in corresponding statements, and end with a final f0 value lower than in statements. It is proposed that the yes–no question marker is a phrase accent (H–). Like the high phrase accent posited by Pierrehumbert for English, this intonational tone is associated after the last tone in the phrase, but in Luganda that last tone is lexical, rather than being an intonational focus marker as in English. This H–accent is subject to upstep in the position after a high tone.
Genetic diversity of marbled goby populations in the Anatolian coasts of the north-eastern Mediterranean
Authors: Seyhan-Ozturk Dilruba , Engin Semih
Published: April 2021

The demographic histories, genetic relationships and population structure of sedentary fishPomatoschistus marmoratus(Risso, 1810), which was sampled from the north-eastern basin of the Mediterranean Sea (including the Turkish coasts of the Black Sea, Aegean Sea, Levantine Sea and Sea of Marmara), were investigated by mitochondrial cytochrome c oxidase subunit I (652 bp) and cytochrome b (526 bp) regions. It was found that the population groups had high haplotype diversity while the nucleotide diversity was quite low for both gene regions. Phylogeographic analyses of the haplotypes indicated that the Levantine population (LEV) were genetically different from other populations. Also, the gene flow between LEV and the other populations was very limited. The results of the analyses of neutrality and mismatch distributions that were applied to the population groups were evaluated as a whole. It was determined that the haplogroup that represents the Black Sea and Sea of Marmara populations (BLAMAR) was stable, but the Levantine population (LEV) was under the sudden demographic expansion model following the population bottleneck. The genetic variance indices indicated sudden demographic expansion following population contraction. This was supported by star-shaped haplotype networks. The reason for this limited gene flow and differentiation between the Levantine population (LEV) and the others was linked with wind-driven offshore transport of the larvae and surface currents in these sub-basins. The timing of the differentiation, demographic histories of populations associated with geological and palaeo-climatic events and current ecological conditions were discussed.
Lessons from practitioners for designing and implementing effective amphibian captive breeding programmes
Authors: Karlsdóttir Berglind , Knight Andrew T. , Johnson Kevin , Dawson Jeff
Published: April 2021

With 40% of global amphibian species threatened with extinction, captive breeding programmes are an increasingly important conservation tool. The highest priority species occur in tropical countries, which presents a number of challenges. We conducted semi-structured interviews with 25 practitioners in Latin America, Africa and Asia to investigate how the effectiveness of amphibian captive breeding programmes could be improved. A thematic analysis identified 94 barriers and enablers across 13 themes. We found that existing programmes commonly followed a reactive and often ineffective four-stage operational model. Subsequently, we developed a proactive operational model, using the barriers and enablers identified by this study, to support programme managers in the implementation of effective programmes. Our findings suggest human dimensions are often critical barriers or enablers across all stages of captive breeding programmes. We recommend the development of strategic partnerships between institutions, including zoos, NGOs, governments and captive breeding programmes, to help overcome these critical barriers and improve the effectiveness of global amphibian conservation. This operational model could be translated to captive breeding programmes for other taxa.
Molecular phylogeny and new light microscopic data ofMetchnikovella spiralis(Microsporidia: Metchnikovellidae), a hyperparasite of eugregarinePolyrhabdinasp. from the polychaetePygospio elegans
Authors: Frolova Ekaterina V. , Paskerova Gita G. , Smirnov Alexey V. , Nassonova Elena S.
Published: April 2021

Metchnikovellids are a deep-branching group of microsporidia, parasites of gregarines inhabiting the alimentary tract of polychaetes and some other invertebrates. The diversity and phylogeny of these hyperparasites remain poorly studied. Modern descriptions and molecular data are still lacking for many species. The results of a light microscopy study and molecular data forMetchnikovella spiralisSokolova et al., 2014, a hyperparasite of the eugregarinePolyrhabdinasp., isolated from the polychaetePygospio elegans, were obtained. The original description ofM. spiraliswas based primarily on the analysis of stained preparations and transmission electron microscopy images. Here, the species description was complemented with the results ofin vivoobservations and phylogenetic analysis based on the SSU rRNA gene. It was shown that in this species, free sporogony precedes sac-bound sporogony, as it occurs in the life cycle of most other metchnikovellids. Spore sacs are entwined with spirally wound cords, and possess only one polar plug. Phylogenetic analyses did not groupM. spiraliswithM. incurvata, another metchnikovellid from the same gregarine species, but placed it as a sister branch toAmphiacantha. The paraphyletic nature of the genusMetchnikovellawas discussed. The taxonomic summary forM. spiraliswas emended.
Immunological underpinnings of Ascaris infection, reinfection and co-infection and their associated co-morbidities
Authors: Magalhães Luisa , Nogueira Denise S. , Gazzinelli-Guimarães Pedro H. , Oliveira Fabricio M. S. , Kraemer Lucas , Gazzinelli-Guimarães Ana Clara , Vieira-Santos Flaviane , Fujiwara Ricardo T. , Bueno Lilian L.
Published: April 2021

Human ascariasis is the most common and prevalent neglected tropical disease and is estimated that ~819 million people are infected around the globe, accounting for 0.861 million years of disability-adjusted life years in 2017. Even with the existence of highly effective drugs, the constant presence of infective parasite eggs in the environment contribute to a high reinfection rate after treatment. Due to its high prevalence and broad geographic distribution Ascaris infection is associated with a variety of co-morbidities and co-infections. Here, we provide data from both experimental models and humans studies that illustrate how complex is the interaction of Ascaris with the host immune system, especially, in the context of reinfections, co-infections and associated co-morbidities.
What is a mental disorder? An exemplar-focused approach
Authors: Stein Dan J. , Palk Andrea C. , Kendler Kenneth S.
Published: April 2021

The question of ‘what is a mental disorder?’ is central to the philosophy of psychiatry, and has crucial practical implications for psychiatric nosology. Rather than approaching the problem in terms of abstractions, we review a series of exemplars – real-world examples of problematic cases that emerged during work on and immediately after DSM-5, with the aim of developing practical guidelines for addressing future proposals. We consider cases where (1) there is harm but no clear dysfunction, (2) there is dysfunction but no clear harm, and (3) there is possible dysfunction and/or harm, but this is controversial for various reasons. We found no specific criteria to determine whether future proposals for new entities should be accepted or rejected; any such proposal will need to be assessed on its particular merits, using practical judgment. Nevertheless, several suggestions for the field emerged. First, while harm is useful for defining mental disorder, some proposed entities may require careful consideration of individualv.societal harm, as well as of societal accommodation. Second, while dysfunction is useful for defining mental disorder, the field would benefit from more sharply defined indicators of dysfunction. Third, it would be useful to incorporate evidence of diagnostic validity and clinical utility into the definition of mental disorder, and to further clarify the type and extent of data needed to support such judgments.
Coronavirus conspiracy suspicions, general vaccine attitudes, trust and coronavirus information source as predictors of vaccine hesitancy among UK residents during the COVID-19 pandemic
Authors: Allington Daniel , McAndrew Siobhan , Moxham-Hall Vivienne , Duffy Bobby
Published: April 2021

Background

Vaccine hesitancy presents an obstacle to the campaign to control COVID-19. It has previously been found to be associated with youth, female gender, low income, low education, low medical trust, minority ethnic group membership, low perceived risk from COVID-19, use of certain social media platforms and conspiracy beliefs. However, it is unclear which of these predictors might explain variance associated with others.

Methods

An online survey was conducted with a representative sample of 4343 UK residents, aged 18–75, between 21 November and 21 December 2020. Predictors of vaccine hesitancy were assessed using linear rank-order models.

Results

Coronavirus vaccine hesitancy is associated with youth, female gender, low income, low education, high informational reliance on social media, low informational reliance on print and broadcast media, membership of other than white ethnic groups, low perceived risk from COVID-19 and low trust in scientists and medics, as well as (to a much lesser extent) low trust in government. Coronavirus conspiracy suspicions and general vaccine attitudes appear uniquely predictive, jointly explaining 35% of variance. Following controls for these variables, effects associated with trust, ethnicity and social media reliance largely or completely disappear, whereas the effect associated with education is reversed.

Conclusions

Strengthening positive attitudes to vaccination and reducing conspiracy suspicions with regards to the coronavirus may have a positive effect on vaccine uptake, especially among ethnic groups with heightened vaccine hesitancy. However, vaccine hesitancy associated with age and gender does not appear to be explained by other predictor variables tested here.
Lessons from the vaginal mesh scandal: enhancing the patient-centric approach to informed consent for medical device implantation
Authors: O'Neill Jennifer
Published: April 2021

The vaginal mesh scandal, in which thousands of women were irreversibly maimed by polypropylene mesh, revealed multilevel failures in medical device regulation and implantation, demonstrating that patient-centric care has not yet fully transcended from policy into practice. In law, informed consent is considered by a two-stage test: reasonable treatment and patient information disclosure. The standard of reasonable treatment is determined according to what is deemed acceptable in accordance with a body of medical opinion. However, such bodies of medical opinion were vulnerable to external influence from device manufactures. Vaginal mesh manufacturers were found to have had financial links to research, royal colleges, and influential clinicians, which then influenced the basis of the evidence-based practice that often guides such bodies of medical opinion. According to the Independent Medicines and Medical Device Safety Report, patients’ mesh complications were also frequently under-reported and patient-based evidence of harm disregarded. Patients were also not sufficiently informed of the material risks or reasonable alternatives to mesh, which is required of the second stage of informed consent pertaining to information disclosure. This paper makes the following recommendations: that conflict of interest disclosure be mandated, that greater value be afforded to patient-based evidence to improve evaluation of treatments, and that information disclosure for informed consent should relate to the risks, benefits, and alternatives to the surgical procedureandmedical device. This will ensure that patients can evaluate whether surgeons are offering unbiased treatment options and are also informed of the potential long-term risks associated with device implantation.
Are we there yet? A review of proposed Aboriginal cultural heritage laws in New South Wales, Australia
Authors: Lingard Kylie , Stoianoff Natalie P. , Wright Evana , Wright Sarah
Published: April 2021

This article examines the extent to which a recent law reform initiative in New South Wales (NSW), Australia—the draft Aboriginal Cultural Heritage Bill 2018 (NSW)—advances the general principles outlined in the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP). The examination reveals some improvements on the current legal framework and some concerning proposals that distance the NSW government from the UNDRIP principles. Key concerns include a proposed transfer of administrative responsibility to Aboriginal bodies with no corresponding guarantee of funding; the continued vesting of key decision-making powers in government; inept provisions for the protection of secret knowledge; and lower penalties for harming cultural heritage than for related offences in existing environmental and planning legislation. Given the bill’s weaknesses, the article explores pragmatic alternatives to better advance the UNDRIP principles.
Ten years of weekly epidemiological teleconference (EpiLag) – an effective and time-efficient tool for infectious disease event information, Germany, 2009–2018
Authors: Milde-Busch Astrid , Zeitlmann Nadine , Mücke Inge , Gilsdorf Andreas , Rexroth Ute , an der Heiden Maria ,   the EpiLag-Working Group
Published: April 2021

In 2009, the Robert Koch Institute (RKI) and the 16 German federal state public health authorities (PHAs) established a weekly epidemiological teleconference (EpiLag) to discuss infectious disease (ID) events and foster horizontal and vertical information exchange. We present the procedure, discussed ID topics and evaluation results of EpiLag after 10 years. We analysed attendance, duration of EpiLag and the frequency of reported events. Participants (RKI and state PHA) were surveyed regarding their satisfaction with logistics, contents and usefulness of EpiLag (Likert scales). Between 2009 and 2018, RKI hosted 484 EpiLag conferences with a mean duration of 25 min (range: 4–60) and high participation (range: 9–16; mean: 15 PHAs). Overall, 2975 ID events (39% international, 9% national and 52% subnational) were presented (mean: 6.1 per EpiLag), most frequently on measles (18%), salmonellosis (8%) and influenza (5%). All responding participants (14/16 PHAs and 9/9 at RKI) were satisfied with the EpiLag's organization and minutes and deemed EpiLag useful for an overview and information distribution on ID events relevant to Germany. EpiLag is time efficient, easily applicable and useful for a low-threshold event communication. It supports PHAs in crises and strengthens the network of surveillance stakeholders. We recommend its implementation to other countries or sectors.
Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study
Authors: Liu Fang , Chang Li , Bai Ting , Liu Xiaojuan , Hu Jinliang
Published: April 2021

The present study attempted to analyse human papillomavirus (HPV) genotype distribution and its association with cervical cytology results in women in western China. The present retrospective analysis was performed in 1089 female outpatients with a positive HPV test result who had undergone a cervical cytology test at the gynaecological clinic, West China Second Hospital, Sichuan University, China, between January 2014 and December 2016. Of the 1089 patients with HPV infection, multiple HPV genotypes were detected in 220 patients (20.20%). Among the 1368 HPV genotypes detected, 1145 (83.70%) were high-risk subtypes. The most common genotypes were HPV-52 (18.64%), HPV-16 (16.59%), HPV-58 (13.23%), HPV-18 (6.80%), HPV-56 (5.56%) and HPV-59 (5.56%). Cervical cytology revealed abnormal cells in 430 (39.49%) patients. The most common diagnoses were atypical squamous cells of undetermined significance (ASC-US; 236 cases, 54.88%), low-grade squamous intraepithelial lesions (LSIL; 151 cases, 35.12%), high-grade squamous intraepithelial lesions (HSIL; 63 cases, 14.65%) and atypical glandular cells (AGC; 21 cases, 4.88%). HPV-66 was significantly associated (P = 0.037) with ASC; HPV-52 and HPV-56 were significantly associated with LSIL (P = 0.009 and 0.026, respectively); HPV-16 (P < 0.001), HPV-33 (P = 0.014) and HPV-58 (P = 0.003) were significantly associated with HSIL; and HPV-16 (P = 0.005) was significantly associated with AGC. HPV-16, HPV-52 and HPV-58 are associated with different diagnoses in patients with positive cervical cytological findings.
Economic Aspects of Settlement in the Oasis of Bukhara, Uzbekistan: An Archaeo-Economic Approach
Authors: Rante Rocco , Trionfetti Federico
Published: April 2021

This paper focuses on the new approach studying variations in city size and the impact that the Silk Road had on the structure of cities, demonstrated through the study of economic aspects of the Bukhara oasis. We use archaeological data, compare the ancient economy to modern ones, use modern economic theory and methods to understand ancient society, and use what we have learned about the ancient economy to understand modern economies better. In sum, we explore the past through the present and the latter through the former. Our main finding is the generation of models able to answer to the city-size distribution in different territories, comparing them between the past and the present. This study first revealed that, through Zipf's Law, we found similarities between modern post-Industrial Revolution and medieval economics. Secondly, we also found that in ancient times the structure of the city was linked with the local economic demand. We have demonstrated this through the study of cities along the Silk Road.
Planned reduction in Fontan fenestration size using the Atrial Flow Regulator
Authors: Aregullin E. Oliver , Samuel Bennett , Vettukattil Joseph
Published: April 2021

Fontan fenestration allows right-to-left shunting increasing cardiac output and oxygen delivery. Increased shunting occurs as cardiac function and ventricular end-diastolic pressures improve, potentially decreasing oxygen saturation. Complete closure may result in impaired Fontan haemodynamics and low cardiac output; however, there are no dedicated devices to reduce fenestration size. We describe Fontan fenestration size reduction using the Atrial Flow Regulator.
Long-term neurodevelopmental effects of intraoperative blood pressure during surgical closure of a septal defect in infancy or early childhood
Authors: Lauritzen Daniel J. , Asschenfeldt Benjamin , Evald Lars , Hjortdal Vibeke E. , Heiberg Johan
Published: April 2021

Background:

Many children born with congenital heart defects are faced with cognitive deficits and psychological challenges later in life. The mechanisms behind are suggested to be multifactorial and are explained as an interplay between innate and modifiable risk factors. The aim was to assess whether there is a relationship between mean arterial pressure during surgery of a septal defect in infancy or early childhood and intelligence quotient scores in adulthood.

Methods:

In a retrospective study, patients were included if they underwent surgical closure of a ventricular septal defect or an atrial septal defect in childhood between 1988 and 2002. Every patient completed an intelligence assessment upon inclusion, 14–27 years after surgery, using the Wechsler Adult Intelligence Scale Version IV.

Results:

A total of 58 patients met the eligibility criteria and were included in the analyses. No statistically significant correlation was found between blood pressure during cardiopulmonary bypass and intelligence quotient scores in adulthood (r = 0.138; 95% CI−0.133–0.389). Although amongst patients with mean arterial pressure < 40 mmHg during cardiopulmonary bypass, intelligence quotient scores were significantly lower (91.4; 95% CI 86.9–95.9) compared to those with mean arterial pressure > 40 mmHg (99.8; 95% CI 94.7–104.9).

Conclusions:

Mean arterial pressure during surgery of ventricular septal defects or atrial septal defects in childhood does not correlate linearly with intelligence quotient scores in adulthood. Although there may exist a specific cut-off value at which low blood pressure becomes harmful. Larger studies are warranted in order to confirm this, as it holds the potential of partly relieving CHD patients of their cognitive deficits.
Mechanical Turk and the “Don’t Know” Option
Authors: Brown Adam R. , Pope Jeremy C.
Published: April 2021

Luskin and Bullock’s (2011) randomized experiment on live-interview respondents found no evidence that American National Election Studies and Time-Sharing Experiments for the Social Sciences respondents hide knowledge behind the “don’t know” (DK) option. We successfully replicated their finding using two online platforms, the Cooperative Congressional Election Study and Google Surveys. However, we obtained different results on Amazon’s Mechanical Turk (MTurk). We attribute this difference to MTurkers’ experience with attention checks and other quality-control mechanisms, which condition them to avoid errors. This conditioning leads MTurkers to hide knowledge behind DK in ways not observed on other platforms. Researchers conducting political knowledge experiments or piloting surveys on MTurk should be aware of these differences.
LEONARD SAVAGE, THE ELLSBERG PARADOX, AND THE DEBATE ON SUBJECTIVE PROBABILITIES: EVIDENCE FROM THE ARCHIVES
Authors: Zappia Carlo
Published: April 2021

This paper explores archival material concerning the reception of Leonard J. Savage’s foundational work of rational choice theory in its subjective-Bayesian form. The focus is on the criticism raised in the early 1960s by Daniel Ellsberg, William Fellner, and Cedric Smith, who were supporters of the newly developed subjective approach but could not understand Savage’s insistence on the strict version he shared with Bruno de Finetti. The episode is well known, thanks to the so-called Ellsberg Paradox and the extensive reference made to it in current decision theory. But Savage’s reaction to his critics has never been examined. Although Savage never really engaged with the issue in his published writings, the private exchange with Ellsberg and Fellner, and with de Finetti about how to deal with Smith, shows that Savage’s attention to the generalization advocated by his correspondents was substantive. In particular, Savage’s defense of the normative value of rational choice theory against counterexamples such as Ellsberg’s did not prevent him from admitting that he would give careful consideration to a more realistic axiomatic system, should the critics be able to provide one.
Systematic review of transdermal treatment options in attention-deficit/hyperactivity disorder: implications for use in adult patients
Authors: Correll Christoph U. , Starling Brittney R. , Huss Michael
Published: April 2021

Background

Adults with attention-deficit/hyperactivity disorder (ADHD) often face delays in diagnosis and remain untreated, despite significant negative impacts. To evaluate the safety and efficacy of transdermal treatment options in children, adolescents, and adults, a systematic literature review was conducted, with a focus on the implications of transdermal therapies for ADHD in adults.

Methods

A MEDLINE/Embase/BIOSIS/SCOPUS database search was conducted December 4, 2019, for English-language articles of interventional clinical trials using transdermal formulations for the treatment of ADHD without publication date limit. Assessed outcomes included efficacy, safety, adherence, abuse potential, cost efficacy, and health-related quality of life.

Results

Of 23 eligible publications, 18 were in children or adolescents (n = 1699; range 23-305), and 5 in adults (n = 274; range 14-90); all included methylphenidate transdermal system (MTS). All seven pediatric publications reporting change in ADHD symptomology from baseline reported a significant improvement with MTS treatment. Similarly, in three adult publications, ADHD symptoms improved significantly with MTS treatment. Safety findings in pediatric and adult studies were comparable; the most frequently reported treatment-emergent adverse events (TEAEs), namely, headache, decreased appetite, and insomnia, were reported in 13/16 (81%) of publications reporting specific TEAEs. MTS-related dermal reactions were mostly mild and transient. Discontinuation due to dermal reactions was reported in 10 studies (range 0%-7.1% [1 of 14 patients]). MTS compliance was high when assessed (97%-99%).

Conclusions

Transdermal therapies provide a useful treatment formulation for ADHD. Studies of MTS and other transdermal formulations, such as amphetamine, in adult patients are needed in this underserved population.
Pharmacologic interventions for antidepressant-induced sexual dysfunction: a systematic review and network meta-analysis of trials using the Arizona sexual experience scale
Authors: Luft Marissa J. , Dobson Eric T. , Levine Amir , Croarkin Paul E. , Strawn Jeffrey R.
Published: April 2021

Background

Despite the prevalence of antidepressant-related sexual side effects, comparisons of treatments for these problematic side effects are lacking.

Methods

To address this, we performed a systematic review and Bayesian network meta-analysis to compare interventions for antidepressant-induced sexual dysfunction in adults. Using PubMed and clinicaltrials.gov, we identified published and unpublished prospective treatment trials from 1985 to September 2020 (primary outcome: the Arizona sexual experience scale [ASEX] score). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation framework.

Results

We identified 57 citations (27 randomized controlled trials, 66 treatment arms, 27 open-label trials, and 3 crossover trials) that evaluated 33 interventions (3108 patients). In the systematic review, 44% (25/57) of trials reported successful interventions; this was more common in open-label (70%, 19/27) compared to placebo-controlled studies (22%, 6/27). In the meta-analysis of placebo-controlled studies that used the ASEX (N = 8), pycnogenol was superior to placebo (standardized mean difference: −1.8, 95% credible interval [CrI]: [−3.7 to 0.0]) and there was evidence that, at a 6% threshold, sildenafil improved sexual dysfunction (standardized mean difference: −1.2, 95% CrI [−2.5 to 0.1]). In the meta-analysis including single-arm studies (15 studies), treatment response was more common with sildenafil, tianeptine, maca, tiagabine, and mirtazapine compared to placebo, but these differences failed to reach statistical significance.

Conclusions

While heterogeneity across randomized controlled trials complicates identifying the single best intervention, multiple trials suggest that sildenafil ameliorates antidepressant-induced sexual dysfunction. More randomized controlled trials are needed to examine the putative efficacy of other interventions.
In (deficit) schizophrenia, a general cognitive decline partly mediates the effects of neuro-immune and neuro-oxidative toxicity on the symptomatome and quality of life
Authors: Maes Michael , Kanchanatawan Buranee
Published: April 2021

Background

Schizophrenia and deficit schizophrenia are accompanied by neurocognitive impairments. The aim of this study was to examine whether a general factor underpins impairments in key Cambridge Neuropsychological Test Automated Battery (CANTAB) probes, verbal fluency test (VFT), world list memory (WLM), True Recall, and mini mental state examination (MMSE).

Methods

We recruited 80 patients with schizophrenia and 40 healthy controls. All patients were assessed using CANTAB tests, namely paired-association learning, rapid visual information processing, spatial working memory, one touch stockings of Cambridge, intra/extradimensional set-shifting (IED), and emotional recognition test.

Results

We found that a general factor, which is essentially unidimensional, underlies those CANTAB, VFT, WLM, True Recall, and MMSE scores. This common factor shows excellent psychometric properties and fits a reflective model and, therefore, reflects a general cognitive decline (G-CoDe) comprising deficits in semantic and episodic memory, recall, executive functions, strategy use, rule acquisition, visual sustained attention, attentional set-shifting, and emotional recognition. Partial least squares analysis showed that 40.5% of the variance in G-CoDe is explained by C-C motif ligand 11, IgA to tryptophan catabolites, and increased oxidative toxicity, and that G-CoDe explains 44.8% of the variance in a general factor extracted from psychosis, hostility, excitation, mannerism, negative symptoms, formal thought disorders, and psychomotor retardation, and 40.9% in quality-of-life scores. The G-CoDe is significantly greater in deficit than in nondeficit schizophrenia.

Conclusions

A common core shared by a multitude of neurocognitive impairments (G-CoDe) mediates the effects of neurotoxic pathways on the phenome of (deficit) schizophrenia.
Determinants of uptake and strategies to improve agricultural insurance in Africa: a review
Authors: Nshakira-Rukundo Emmanuel , Kamau Juliet Wanjiku , Baumüller Heike
Published: April 2021

Weather shocks affect smallholder farmers and pastoralists in Sub-Saharan Africa unequally. Agricultural insurance has emerged as a safety net option to protect farmers’ welfare. However, in comparison to other regions, fewer African farmers and pastoralists have adopted agricultural insurance. This review synthesises broad recent literature on why insurance take-up has remained low and highlights six key themes, including: (1) product quality, (2) product design, (3) affordability, (4) information and education, (5) behavioural and sociocultural factors, and (6) the role of government in enabling markets. We shed light on how insurance uptake can be encouraged.
Phonological transfer effects in novice learners: A learner's brain detects grammar errors only if the language sounds familiar
Authors: Gosselke Berthelsen Sabine , Horne Merle , Shtyrov Yury , Roll Mikael
Published: April 2021

Many aspects of a new language, including grammar rules, can be acquired and accessed within minutes. In the present study, we investigate how initial learners respond when the rules of a novel language are not adhered to. Through spoken word-picture association-learning, tonal and non-tonal speakers were taught artificial words. Along with lexicosemantic content expressed by consonants, the words contained grammatical properties embedded in vowels and tones. Pictures that were mismatched with any of the words’ phonological cues elicited an N400 in tonal learners. Non-tonal learners only produced an N400 when the mismatch was based on a word's vowel or consonants, not the tone. The emergence of the N400 might indicate that error processing in L2 learners (unlike canonical processing) does not initially differentiate between grammar and semantics. Importantly, only errors based on familiar phonological cues evoked a mismatch-related response, highlighting the importance of phonological transfer in initial second language acquisition.
Assessing nutritional value of ready-to-eat breakfast cereals in the province of Quebec (Canada): a study from the Food Quality Observatory
Authors: Perron Julie , Pomerleau Sonia , Gagnon Pierre , Gilbert-Moreau Joséane , Lemieux Simone , Plante Céline , Paquette Marie-Claude , Labonté Marie-Ève , Provencher Véronique
Published: April 2021

Objective:

The Food Quality Observatory was created in the province of Quebec (Canada) in 2016. In this study, the Observatory aimed to generate a methodology to (1) test the use of sales data combined with nutrient values to characterise the nutritional composition of ready-to-eat (RTE) breakfast cereals offered and purchased in the province of Quebec (Canada) and (2) verify the extent to which a front-of-pack label based on the percentage of daily value (DV) for total sugar, as a strategy to improve the food supply, would be distributed in this food category.

Design:

Nutritional information were obtained by purchasing each RTE breakfast cereal available in the Greater Montreal area. Cereals were then classified according to their processing type.

Setting:

The nutritional values of 331 RTE breakfast cereals available in Quebec were merged with sales data covering the period between May 2016 and May 2017. A total of 306 products were successfully cross-referenced.

Results:

Granola and sweetened cereals were the most available (36·6 % and 19·6 %, respectively) and purchased (19·8 % and 40·9 % of sales, respectively). When compared with other types of cereals, granola cereals had a higher energy, fat, saturated fat, protein content and a lower Na content. A larger proportion of chocolate (65 %) and sweetened cereals (49 %) were above 15 % of the DV for sugar.

Conclusions:

This study showed that the methodology developed generates important data to monitor nutritional quality of the food supply and ultimately contribute to improve the nutritional quality of processed foods.
Household structure and concurrent stunting and overweight among young children in Indonesia
Authors: Ciptanurani Ceria , Chen Hsin-Jen
Published: April 2021

Objective:

To examine the association of household type and household composition with concurrent stunting and overweight in young children from urban and rural Indonesia.

Design:

This study is a secondary data analysis using a nationally representative cross-sectional survey. Household structure was analysed as household type, household size, number of working adults, number of dependent adults and children, and household head’s gender. We defined ‘concurrent stunting and overweight’ as height-for-age Z-score <–2 and weight-for-height Z-score >+2 based on WHO growth standards. Multivariable logistic regression to test the aforementioned association was performed separately for urban and rural areas.

Setting:

Data were from Indonesia Basic Heath Research 2013.

Participants:

Children aged 2–5 years (n 45 050).

Results:

The prevalence of concurrent stunting and overweight children was 5·6 %. In rural areas, this prevalence differed significantly by household types and the highest prevalence was among children in nuclear two-parent households (6·8 %). In rural areas, children in extended households had lower odds of concurrent stunting and overweight than those from nuclear households (OR = 0·73, 95 % CI 0·59, 0·92). In urban areas, household size and number of working adults were significantly associated with the decreased odds of concurrent stunting and overweight in children.

Conclusions:

Household structure was associated with children’s concurrent stunting and overweight in urban and rural regions of Indonesia. The patterns of the association might differ between urban and rural regions, but no significant interaction term was found.