bluuebunny/crossref_metadata_2025 huggingface dataset:
Harmonizácia daňového práva v Európskej únii
Authors:   Pavol Jozef Šafárik University in Košice, Ristveyová Sandra
Published: February 2023

Harmonization of EU tax law The article entitled "Harmonization of tax law in the EU" deals with the issue of harmonization of tax liability in the European Union, while the thesis analyzes taxes in the European Union and develops the harmonization of individual taxes. Harmonization is implemented in the area of taxes and indirect taxes. The objectives enshrined in the EU Treaties are achieved through other legislation. In general, the Directive sets out, as a legal act, the objectives to be achieved by the EU Member States. The article contains the most current directives concerning the harmonization of value added taxes. We confirmed the theoretical control and implementation of the EU into the legislation of the Slovak Republic for accidental interventions of the European Union. Analysis of individual deadlines and implementation of confirming work objectives and analysis of harmonization processes in the field of control and determination of taxes, as well as harmonization of processes in the field of tax administration, in EU conditions and their impact on the control of orders in the Slovak Republic. URL: https://vsas.fvs.upjs.sk/
Ориентир коллизионного регулирования в современных условиях глобализации
Authors: Леанович Елена
Published: February 2023

В статье показана специфика коллизионного регулирования в условиях современных вызовов глобализации. Раскрыты причины и следствие осложнения практики разрешения частных отношений с иностранным элементом и усиления роли публично-правовых предписаний в последние годы. Приведены выводы современной доктрины международного частного права в свете теорий глобального управления и открытых обществ. На основе расширенного методологического подхода с учетом нормативных, исторических, социокультурных и экономических детерминант выявлен и описан ориентир коллизионного регулирования. Дано сущностное определение коллизионного регулирования. Сформулированы дополнения в статью 1093 Гражданского кодекса Республики Беларусь, а также сделан вывод о возможном совершенствовании коллизионного регулирования в случае кодификации белорусского коллизионного права.
Эволюция научных взглядов на теории трудовой миграции
Authors: Чжуаньсунь Цяочу
Published: February 2023

Актуальность данной статьи определяется существенно возросшей интенсивностью миграционных процессов, ростом их влияния на экономические, общественно-политические, социально-демографические параметры развития стран. Как следствие, повышается потребность широкой совокупности сторон в объяснении причин наблюдаемых процессов, инструментария влияния на них, методов прогнозирования миграционных потоков. Поиск ответов на эти вопросы лежит в плоскости теорий миграции и их составного элемента — теорий трудовой миграции. Ряд авторов критикуют современное состояние теории трудовой миграции, указывая на снижение интенсивности разработок, негативно сказывающееся на глубине понимания миграционных процессов. В подобных условиях видятся важными и актуальными ретроспективная оценка развития взглядов на теорию трудовой миграции и характеристика наиболее важных работ в рассматриваемой сфере.
Metacognition and Colours for Inclusion: results of an explorative activity in a simplexity approach
Authors: Paolo Alessio Di
Published: February 2023

Schools and teachers are called upon, in the age of complexity, to deal with a plurality of problems related to the many stimuli arising from the personal and environmental influences of students. Complexity requires teachers to be in constant training and updating, to be able to propose flexible and adaptable teaching paths for the individual learner. This type of action implies a change of perspective in the way of working, leading to the stimulation of lateral thinking, capable of generating creativity. Creativity and lateral thinking imply the activation of metacognitive mechanisms, which are useful for teachers to reflect on their actions and improve their work with students, especially from an inclusive perspective. This paper presents the results of an exploratory activity, conducted on 657 teachers in training at the university of salerno, as part of the training activities for teaching support to pupils with special educational needs. The aim was to investigate whether teachers in training can develop lateral thinking, based on suggestions derived from de bono's studies (2015a) and, specifically, his theory of "the six hats for thinking" highlighting points of agreement with the theory of simplexity proposed by berthoz (2011).
Self-Directed Interdisciplinary Curriculum Trends in Higher Education
Authors:   The Korean Society of Culture and Convergence, Min Jeeyoung
Published: February 2023

This study examined self-directed interdisciplinary curriculum trends in higher education by delving into the self-directed interdisciplinary curricula (SDIC) of Korean universities, compared to those of U.S. universities. Data sources included SDIC information from the individualized studies program websites and hyperlinked documents. The analysis centered on (1) whether a student should include interdisciplinary independent study and experiential learning courses and (2) whether a student was given support in curriculum design and course study. Results revealed that U.S. and Korean universities enacted SDIC under different names to make the traditional curriculum diverse and flexible. The former required students to develop course plans, including interdisciplinary independent study and experiential learning courses. The latter encouraged students to design course plans to improve their multidisciplinary expertise and skills. Both SDIC were oriented toward the shared object: to foster individuals equipped with creativity and interdisciplinary competencies to meet the needs of society and industry. U.S. universities provided diverse aids to students who planned to take the SDIC. Korean universities gradually secured professionals to help students design and complete the SDIC. Based on the results, I suggested management systems of SDIC in higher education.
Analysis of a Single Crystal Solidification Process of an Ni-based Superalloy using a CAFE Model
Authors: Jeong Jae Jun , Lee HyungSoo , Yun Dae Won , Jeong Hi Won , Yoo Young-Soo , Seo Seong-Moon , Lee Je Hyun
Published: February 2023

The efficiency of gas turbines depends on the gas turbine working temperature. Single crystal blades are being applied more often than equiaxed blades in gas turbine engines, to increase the turbine inlet temperature, resulting in enhanced turbine engine efficiency. Single crystal blades endure creep conditions at high temperature better than polycrystal blades because the single crystals do not include grain boundaries. The single crystal process is a breakthrough technology, however, production yield is relatively low compared with polycrystal, and their mechanical properties depend on the crystallographic orientation of the single crystals. In this study, a thermal simulation model, the 3D cellular automation-finite element (CA-FE), was used on the single crystal process with the Bridgman method. The simulation model was well expected, by analysis of the microstructure and EBSD, on the grain selection in the single crystal process. The evolution of single crystal grains was analyzed on process of grain selection in start block and spiral selector. Single crystal orientation was also investigated to determine the effect of nucleation density, forming in the initial stage of solidification.
Thermal-Cycling-Induced Si3N4 Damage in Semiconductor Devices Assembled Utilizing a Lead-on-Chip Package
Authors: Lee Seong-Min , Kim Yeon-Wook
Published: February 2023

This article shows how fractures in the Si3N4 layer, which comprises the top layer of semiconductor devices encapsulated utilizing a lead-on-chip (LOC) packaging technique, are influenced by changes in the lead-frame materials and thermal-cycling test conditions. Using thermal-cycling tests, it was found that fractures in the Si 3 N 4 layer are the most sensitive to changes in the lead-frame materials at the early stage of thermal-cycling, between -65sup>oC and 150sup>oC. Through SEM examinations and stress simulations, this work shows that adopting a copper lead-frame with a CTE-value similar to that of a package body effectively prevents filler-driven Si3N4 damage, providing semiconductor devices with better reliability margins during thermal-cycling.
Battery Cycle Stability in Additive-free MAX(Ti3AlC2) Li-ion Battery Anode
Authors: Hong Jae-Young , Park Byoung-Nam
Published: February 2023

We fabricated an additive-free MAX(Ti3AlC2) phase Li-ion battery (LIB) electrode using the electrophoretic deposition (EPD) method. In this study, MAX, a precursor of MXene, which has recently been receiving great attention as a negative electrode material for LIBs, was manufactured as a coin cell through EPD rather than the conventional slurry system. We excluded the effect of additives on the electrochemical performance, enabling evaluation of the intrinsic electrochemical properties related to battery charging and discharging. As a result, the battery using MAX as an anode material showed a large specific capacity of 148.2 mAh/g in the first discharge and superior cycle stability. Enhanced cycle stability and reversible electrochemical reactions were attributed to activation of faradaic and non-faradaic behavior, i.e., pseudocapacitive behavior, caused by delamination of the MAX(Ti3AlC2) into MXene (Ti3C2). This was confirmed by the decrease in the charge transfer resistance and the increase in total capacitance at the interface, using electrochemical impedance spectroscopy and cyclic voltammetry measurements. In addition, the activation of pseudocapacitive behavior was confirmed by the change in kinetic mechanism, as evidenced from a significant increase in the Li ion diffusivity with cycles. These results demonstrate that MAX(Ti3AlC2) is promising as an anode material for LIBs and at the same time shows potential for tuning electrochemical properties through the electrochemical delamination process.
Adoption of Mechanical Transplanting of Rice (MTR) Among Rice Growers in the Rice-Zone of Punjab, Pakistan
Authors: Umar Muhammad , Ali Shoukat , Ali Asghar , Bashir Muhammad K. , Nawaz Naima , Khan Muhammad H. N. , Riaz Amir
Published: February 2023

We conducted this study to analyze the adoption of Mechanical Transplanting of Rice (MTR) in one of the prominent rice-producing districts Gujranwala of Punjab, Province. Rice has been a significant source of income in this area. A total of 220 rice growers, were selected using the non-probability method of selection from Wazirabad and Kamoki tehsils of district Gujranwala. Selected respondents were interviewed face to face on a structured questionnaire which was pre-tested and validated before final data collection. Collected data were analyzed using Statistical Package for Social Sciences (SPSS). Results were distributed into three sections (i) demographic profile, (ii) relative advantage of MTR and (iii) constraints analysis. Demography unveiled that young age farmers had less inclination towards rice growing, although the majority of respondents had formal education, had ownership of their lands and farmers were irrigating rice crops using tube well. As for as relative advantage was concerned, MTR relatively produced a high extent in terms of effectiveness (X̅ = 4.04, SD=0.62) due to high efficiency, less labour intensive, and high yield. Mandatory use of lesser land levellers, maintenance issues of MTR, unskilled labour and inadequate training for the farmers were prominent consents aced by the MTR user. This study urges more technical backstopping from the concerned institutions to foster the adoption of MTR on the farm level.
Linking Socio-Economic Traits with the Adoption of Weed Management Practices (WMP) in Punjab, Pakistan
Authors: Usman Muhammad , Hina Humaira , Mushtaq Shama , Aslam Sadia , Nawaz Naima , Rasool Asima , Fatima Zareen
Published: February 2023

Agricultural growth is obligatory for sustainable rural development and meeting the food requirements for the increasing population. Weeds put biotic stress on the crops and cause yield decline eventually. In this study, we explored the effect of socio-economic attributes of the farmers on the adoption of weed management practices (WMP) in four cropping systems (Rice-Wheat, Rice, Potato, Rice-Maize and Rice-Peas) of the Punjab, Province. Face-to-face interviews were conducted with the 356 respondents chosen through a proportionate sampling method from the District Gujranwala of Punjab. Data were analyzed using Statistical Package for Social Sciences and frequency, percentage and regression analysis was applied to the data. Results confirmed that respondents' age, education and income were statistically significant (P0.05) with the adoption of WMP. As for as information sources were concerned, the association was significant in R-P (P0.05) and R-Peas (P0.05) cropping systems. This study endorsed that socio-economic characteristic had a key role in technological adoption. To accelerate the adoption, training programs for the farmers, provision of quality weedicides, subsidized inputs and awareness campaigns are suggested.
Implementing Universal Design for Learning in Introduction to American Government
Authors: Javian Katharine
Published: February 2023

Universal Design for Learning (UDL) is an approach to instructional design that encourages instructors to create learning environments that are accessible to students regardless of their disability status. The idea is that every student learns differently and when we design courses that anticipate and break down common barriers to learning, we help all students. This paper provides a brief overview of UDL and offers tips and strategies for its implementation. The paper also offers an American Government syllabus as an example resource.
Institutions of Engagement: Political Participation in College Yearbooks
Authors: McSweeney Patrick
Published: February 2023

College campuses are an important location for young people to fight for their interests. Throughout the years, major events on campuses have been covered by student journalists and archived in college yearbooks. Yearbooks are most often student run and independent from the campus administration providing an example of students telling the story of students. Therefore, as our students explore these books, they will observe events occurring in familiar locations making it easier to relate and connect with the individuals involved. In this paper I describe a lesson where students use college yearbooks as a hands-on tool to help them understand the more complex history of student civic engagement. Beyond a lesson on civic engagement, students will also learn more about their institution as they observe changes and continuities over time. Exploring yearbooks also provides students with experience exploring archives and analyzing qualitative data.
PARADOKS KOPERASI MATI SEGAN HIDUP TAK MAU
Authors: Ramdani Edon , Martono Adi
Published: February 2023

Cikal bakal koperasi di Indonesia sudah ada sejak akhir abad ke 19 dan tanggal 12 Juli 1947 ditetapkan sebagai hari Koperasi Indonesia dalam kongres pertama koperasi. Namun demikian, hingga saat ini koperasi belum mampu memberikan kontribusi yang nyata pada perekonomian Indonesia sebagaimana dicita-citakan Mohammad Hatta, Bapak Koperasi Indonesia. Hingga saat ini sumbangan koperasi bagi perekonomian Indonesia baru mencapai angka 5,2 persen dengan jumlah sekitar 123.000 unit koperasi dan 25 juta anggota. Jumlah tersebut terhitung sangat kecil jika dibandingkan dengan UMKM yang mampu berkontribusi 60 persen lebih. Pada tahun 1953, Bung Hatta sebagai Bapak koperasi Indonesia telah mencanangkan bahwa koperasi merupakan salah satu jalan untuk melepaskan diri dari kemiskinan pasca penjajahan Belanda. Namun demikian, apa yang dicanangkan oleh Bung Hatta dan upaya pemerintah dalam mendorong tumbuhnya koperasi melalui berbagai kemudahan dalam regulasi belum memberikan dampak signifikan bagi perkembangan perekonomian di Indonesia, tetap saja badan usaha dengan sistem ekonomi kapitalis yang menguasai perekonomian. Banyak tantangan yang dihadapi oleh koperasi seperti kondisi persaingan di mana koperasi bersaing dengan sistem ekonomi kapitalis dalam mengambil peran dalam sistem perekonomian, kesiapan sarana dan prasarana koperasi yang kalah dibandingkan bentuk badan usaha lainnya. Koperasi tidak hanya menghadapi tantangan dari sisi internal namun juga sisi eksternal. Berdasarkan uraian yang telah disampaikan maka penulis tertarik untuk meneliti kembali mengenai kontribusi koperasi kepada perekonomian Indonesia. penelitian ini bertujuan untuk mengkaji seberapa besar sebenarnya sumbangan kontribusi yang dapat diberikan koperasi bagi perekonomian Indonesia. Sehubungan dengan hal tersebut, penelitian ini dilakukan dengan fokus pada aspek kinerja koperasi di Indonesia. Pada penelitian ini, penulis menggunakan metode kualitatif deskriftif dengan metode studi literatur yang bersumber dari penelitian-penelitian terdahulu berupa artikel-artikel, ulasan para ahli, buku-buku, studi keperpustakaan dan media cetak lainnya. Diharapkan hasil penelitian ini dapat menambah wawasan mengenai perkembangan koperasi dan kinerjanya dalam menopang pembangunan perekonomian Indonesia. Kemudian hasil dari penelitian ini berupa artikel yang akan penulis terbitkan pada Jurnal Nasional terakreditasi.
Workflow for computational characterization of PDMS cross-linked systems
Authors: Kampmann Steffen , Croy Alexander , Dianat Arezoo , Cuniberti Gianaurelio
Published: February 2023

The aim of this work is to demonstrate a computational workflow for the generation of cross-linkable viscoelastic polymers and the determination of elastic and hyperelastic properties by means of all-atoms classical molecular dynamics simulations, using polydimethylsiloxane (PDMS) as an example. To improve the computational efficiency of the workflow, a phenomenological description of the cross-linking process is chosen instead of a quantum mechanical description of the cross-linking mechanism. The structures produced differ in their conversion degree of cross-linking (cdc) of 60, 70, and 80 percent and their quantity ratio between polymer chains and cross-linking units of 2 to 1 and 5 to 1. In order to exclude finite size effects of the molecular systems as much as possible, large systems of about 40,000 atoms are considered. Furthermore, for each possible configuration from the combination of cdc and the ratio of polymer chains to cross-linking units, six structures different from each other are used. Tensile and compression tests are performed to determine mechanical properties. A dependence of stresses in the deformation direction on strain rate is found for strain rates 107, 108, and 109 1/s. As the cdc increases, an increase in the stress values is observed in the tensile tests. To determine the viscoelastic material properties, relaxation tests are performed following the tensile tests. Thereby, the determined relaxed stresses after the tensile test rise with the increase of the cdc. Furthermore, no large stress deviations, .34 MPa maximum, between structures differing by chain to linker ratio are observed with the Ogden model. The computational workflow shows that classical all-atom molecular dynamics simulations can be a suitable method for structure generation and subsequent characterization of elastic and hyperelastic properties of cross-linked polymers.
Oxidative stress induced by berberine-based mitochondria-targeted low temperature photothermal therapy
Authors: Hu Hongzhi , Song Qingcheng , Yang Wenbo , Zeng Qianwen , Liang Zihui , Liu Weijian , Shao Zengwu , Zhang Yiran , Chen Chao , Wang Baichuan
Published: February 2023

Introduction: Mitochondria-targeted low-temperature photothermal therapy (LPTT) is a promising strategy that could maximize anticancer effects and overcome tumor thermal resistance. However, the successful synthesis of mitochondria-targeted nanodrug delivery system for LPTT still faces diverse challenges, such as laborious preparations processes, low drug-loading, and significant systemic toxicity from the carriers.

Methods: In this study, we used the tumor-targeting folic acid (FA) and mitochondria-targeting berberine (BBR) derivatives (BD) co-modified polyethylene glycol (PEG)-decorated graphene oxide (GO) to synthesize a novel mitochondria-targeting nanocomposite (GO-PEG-FA/BD), which can effectively accumulate in mitochondria of the osteosarcoma (OS) cells and achieve enhanced mitochondria-targeted LPTT effects with minimal cell toxicity. The mitochondria-targeted LPTT effects were validated both in vitro and vivo.

Results:In vitro experiments, the nanocomposites (GO-PEG-FA/BD) could eliminate membrane potential (ΔΨm), deprive the ATP of cancer cells, and increase the levels of reactive oxygen species (ROS), which ultimately induce oxidative stress damage. Furthermore, in vivo results showed that the enhanced mitochondria-targeted LPTT could exert an excellent anti-cancer effect with minimal toxicity.

Discussion: Taken together, this study provides a practicable strategy to develop an ingenious nanoplatform for cancer synergetic therapy via mitochondria-targeted LPTT, which hold enormous potential for future clinical translation.
Disseminated Talaromyces marneffei infection after renal transplantation: A case report and literature review
Authors: Xu Liang , Chen Xiuxiu , Yang Xuying , Jiang Hongtao , Wang Jianli , Chen Shaowen , Xu Jian
Published: February 2023

We reported a 31-year-old man who received renal transplantation for more than 2 years. He was admitted to our hospital on 9 March 2022 due to intermittent diarrhea accompanied by leukopenia for more than 1 month. The patient successively developed high fever, cough, anemia, weight loss, gastrointestinal bleeding, and liver function impairment. Computed tomography (CT) revealed a slight inflammation in the lower lobes of both lungs, enlargement of the lymph nodes in the retroperitoneal and the root of mesenteric areas, and hepatosplenomegaly. Talaromyces marneffei was detected by metagenomics next-generation sequencing (mNGS) in blood and bronchoalveolar lavage fluid, and the pathogen was subsequently verified by blood culture. After endoscopic hemostatic therapy and antifungal therapy with voriconazole and amphotericin B cholesteryl sulfate complex, the patient was successfully discharged. Oral voriconazole was given regularly after discharge. Diarrhea, fever, enlargement of the lymph nodes, and endoscopic evidence of erosion may indicate intestinal T. marneffei infection. Although the mortality of T. marneffei infection after renal transplantation is very high, timely and effective antifungal therapy with amphotericin B cholesteryl sulfate complex is still expected to improve its prognosis.
Body mass index and atrial fibrillation recurrence post ablation: A systematic review and dose-response meta-analysis
Authors: Liu Fuwei , Song Tiangang , Hu Qingwen , Zhu Xin , Zhao Huilei , Tan Ziqi , Yu Peng , Ma Jianyong , Luo Jun , Liu Xiao
Published: February 2023

Objectives

The aim of this study was to evaluate the shape of the dose-response relationship between body mass index (BMI) and atrial fibrillation (AF) recurrence in patients who have undergone radiofrequency ablation.

Methods

Studies investigating BMI and AF recurrence in patients with AF after ablation were identified through electronic searches in the PubMed, EMBASE, and Cochrane Library databases. The potential non-linear relationship was fitted using robust error meta-regression. Our study was registered with PROSPERO (CRD42019121373).

Results

Twenty-six cohort studies with 7,878 cases/26,450 individuals were included, and a linear dose-response relationship between BMI and AF recurrence (Pnon–linearity = 0.12) was found. The risk of AF recurrence in patients with a BMI over 28 was significantly increased. Specifically, for each 5 kg/m2 increase in BMI, the risk of AF recurrence increased by 15% (95% CI: 1.08–1.22) with moderate heterogeneity (I2 = 53%). Subgroup analyses showed that the pooled risk ratio was not significantly changed in subgroup analysis adjustment for the following important potential intermediate factors: left atrial diameter and obstructive sleep apnea.

Conclusion

This study showed that there is a borderline positive linear association between BMI and AF recurrence post ablation. Overweight and obesity are significantly associated with AF recurrence.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42019128770.
Study on the impact of industrial green development and technological innovation on employment structure
Authors: Li Yue , Hu Mingzhao , Zhao Lingdi
Published: February 2023

Exploring the relationship between industrial green development, technological innovation, and employment structure, especially the impact between industrial green development and technological innovation on employment structure, is of enormous theoretical and practical importance to achieve high-quality employment as well as optimize the employment structure of China. Thirty Chinese provinces’ data from 2009 to 2019 is adopted to assess industrial green development levels. Considering the above, this research innovatively integrates industrial green development, technological innovation, and employment structure into an analytical framework, and empirically investigates the effects of the two factors and their interaction on employment structure by adopting a two-way fixed effects model. The specific conclusions are presented as follows. Firstly, China’s industrial green development levels exhibit a fluctuating and rising time-series evolutionary feature from 2009 to 2019 and have regional differences. Secondly, industrial green development, technological innovation, and their interaction are conducive to optimizing China’s employment structure. Thirdly, the eastern and northeastern areas’ employment structure optimization is boosted by industrial green development. However, the corresponding regression coefficients in the western and central areas are not significant. The northeastern, eastern, and western areas’ technological innovation encourages employment structure improvement. Instead, the employment structure is hampered by technological innovation in the central region. An interaction between industrial green evolution and technological innovation positively affects relevant employment structures in the four regions. Specific results of this research are of necessary theoretical significance and the realistic reference price for whether industrial green development and the interplay affect employment structure.
Mineral content estimation for salt lakes on the Tibetan plateau based on the genetic algorithm-based feature selection method using Sentinel-2 imagery: A case study of the Bieruoze Co and Guopu Co lakes
Authors: Guo Hengliang , Dai Wenhao , Zhang Rongrong , Zhang Dujuan , Qiao Baojin , Zhang Gubin , Zhao Shan , Shang Jiandong
Published: February 2023

Salt lakes on the Tibetan Plateau (TP) are rich in lithium (Li), boron (B) and other mineral resources, and accurate assessment of the mineral content and spatial distribution of the brine in those salt lakes is important to guide the development and utilization of their mineral resources. There are few studies estimating the mineral content of salt lakes on the TP due to the lack of in situ investigation data. This study introduced an intelligent prediction model combining a feature selection algorithm with a machine learning algorithm using Sentinel-2 satellite data to estimate the Li, B, and TDS contents of Bieruoze Co and Guopu Co lakes on the TP. First, to enrich the spectral information, four mathematical transformations (reciprocal, logarithmic, reciprocal of logarithm, and first-order derivative) were applied to the original bands. Then, feature selection was performed using the genetic algorithm (GA) to select the optimal input variables for the model. Finally, prediction models were constructed by partial least squares regression (PLSR), multiple linear regression (MLR), and random forest (RF). The results showed that: 1) The spectral mathematical transformation provided rich spectral information for the mineral content estimation. 2) The performance of the estimation model constructed by the feature optimization method using GA was better than that of the estimation model constructed based on all spectral bands. Based on GA for feature optimization, the MAPE of GA-RF for estimating Li, B and TDS contents on the testing set was reduced by 77.52%, 28.54% and 36.79%, respectively. 3) Compared with the GA-MLR and GA-PLSR models, GA-RF estimated Li (R2=0.99, RMSE=1.15  mg L-1, MAPE=3.00%), B (R2=0.97, RMSE=10.65  mg L-1, MAPE=2.73%), and TDS (R2=0.93, RMSE=0.60 g L-1, MAPE=1.82%) all obtained the optimal performance. This study showed that the combination of the GA-based feature selection method and the RF model has excellent performance and applicability for monitoring the content of multiple minerals using Sentinel-2 imagery in salt lakes on the TP.
Design method of frequency similarity relation for shaking table model test
Authors: Guo Mingzhu , Chen Xudong , Zeng Jinyan
Published: February 2023

It is very important to determine the dynamic similarity relation in the shaking table model test. The accurate dynamic similarity relation can make the model reflect the dynamic characteristics of the prototype to the greatest extent. This paper describes the principle of similarity design for shaking table model test and reviews the related literature. According to the different research objects and purposes, four common similarity design methods including separation similarity method, artificial mass method, less artificial mass method and ignoring gravity method are summarized. Analysis of the shortcomings of the method of deriving frequency compression ratio from static factors in the design of seismic wave similarity relation. The Duhamel integral analytic expression of the structure motion equation under earthquake is analyzed. The seismic response of the structure is closely related to the natural vibration frequency of the structure. A design method using frequency as input seismic wave similarity design control quantity is proposed. The natural vibration frequencies of the prototype and the model are studied by means of the Gonza landslide field ground pulsation test and the model white noise excitation. A new frequency compression ratio design scheme is given from the perspective of dynamic similarity. It is of great reference significance to optimize the dynamic similarity design of shaking table model test and improve the accuracy of test results.
Dynamic mechanical properties and energy dissipation analysis of frozen sandstone with initial damage
Authors: Xie Qihang , Chen Yanlong , Lyu Haoyan , Gu Jun , Chen Yuanguang , Cui Huidong , Wu Peng
Published: February 2023

Damaged rock masses on the slopes of open pit coal mines are prone to geological disasters such as landslides under low temperatures and dynamic loads such as blasting impacts. Based on the Low Temperature Split Hopkinson Pressure Bar (LT-SHPB) system, dynamic compressive tests were done on sandstone specimens, which were damaged by uniaxial loading and unloading test. Dynamic stress–strain curves and dynamic mechanical properties of frozen sandstone with initial damage were analyzed as well as the energy dissipation characteristics. The results indicate that both compressive state and plastic deformation state of the dynamic stress-strain curves increase with the increase of the damage value. Dynamic peak stress and dynamic elastic modulus exhibit an evident damage weakening effect while the dynamic peak strain, in contrast, exhibits a damage enhancement effect. In addition, all three dynamic mechanical properties of the damaged frozen sandstone exhibit an impact effect. The dissipation energy ratio and reflection energy ratio of frozen sandstone increase with the increase of initial damage value while the transmission energy ratio decreases. With the increase of initial damage value and strain rate, the energy utilization rate during the sandstone failure process increases, resulting in more small fragments and powders.
Teachers’ authentic strategies to support student motivation
Authors: Radil Amanda I. , Goegan Lauren D. , Daniels Lia M.
Published: February 2023

Introduction

Most theories of motivation have largely developed from the work of scholars rather than the perspectives of teachers. This means that although researchers have many recommendations to guide the way teachers motivate students, there is little understanding of what teachers naturally do to support student motivation. The purpose of this study was to prioritize teachers’ perspectives by asking them, separate from theory, what they do to motivate students.

Methods

Forty-two practicing teachers completed an open-ended online survey in which they described their personal strategies for motivating students. We used thematic analysis to identify codes and themes from practicing teachers’ responses in a qualitative descriptive design.

Results

We identified 36 discrete codes that gave rise to nine themes: relevance, interest, relationships, effort, safe environment, goals, student self-regulated learning, delivery, and rewards. Member checks were completed to provide evidence of confidence in the results.

Discussion

All of the strategies that teachers described align with recommendations motivation researchers would make with the exception of rewards, which, from a research perspective, are often discouraged. We discuss the results in light of motivation design principles and their relevance to partnering with teachers as a ubiquitous influence on student motivation.
PTH 1-34 promoted bone formation by regulating iron metabolism in unloading-induced bone loss
Authors: Che Jingmin , Ren Weihao , Chen Xin , Wang Fang , Zhang Gejing , Shang Peng
Published: February 2023

PTH 1-34 (teriparatide) is approved by FDA for the treatment of postmenopausal osteoporosis. Iron overload is a major contributing factor for bone loss induced by unloading. Whether iron metabolism is involved in the regulation of PTH 1-34 on unloading-induced osteoporosis has not yet been reported. Here, we found that PTH 1-34 attenuated bone loss in unloading mice. PTH 1-34 regulated the disturbance of iron metabolism in unloading mice by activating Nrf2 and further promoting hepcidin expression in the liver. In addition, the Nrf2 inhibitor selectively blocked hepcidin expression in the liver of unloading mice, which neutralized the inhibitory effect of PTH 1-34 on bone loss and the recovery of iron metabolism in unloading mice. Finally, we found that PTH 1-34 promoted the differentiation and inhibited apoptosis of osteoblasts by regulating iron metabolism and maintaining redox balance under unloading conditions. Our results suggested that PTH 1-34 promoted bone formation by regulating iron metabolism under unloading conditions.
Remote glucose monitoring is feasible for patients and providers using a commercially available population health platform
Authors: Crossen Stephanie S. , Romero Crystal C. , Lewis Carrie , Glaser Nicole S.
Published: February 2023

Objective

Remote patient monitoring (RPM) holds potential to enable more individualized and effective care for patients with type 1 diabetes (T1D), but requires population analytics to focus limited clinical resources on patients most in need. We explored the feasibility of RPM from patient and provider standpoints using a commercially available data analytic platform (glooko Population Health) among a cohort of youth with T1D.

Study design

Patients aged 1-20 years with established T1D (≥12 months) and CGM use (≥3 months) were recruited to participate. Participants’ CGM devices were connected to the glooko app and linked to the research team’s glooko account during a one-month baseline period. This was followed by a six-month intervention period during which participants with >15% of glucose values >250 mg/dl or >5% of values <70 mg/dl each month were contacted with personalized diabetes management recommendations. Participants were surveyed about their experiences, and effects on glycemic control were estimated via change in glucose management indicator (GMI) generated from CGM data at baseline and completion. Changes in time spent within various glucose ranges were also evaluated, and all glycemic metrics were compared to a non-randomized control group via difference-in-difference regression, adjusting for baseline characteristics.

Results

Remote data-sharing was successful for 36 of 39 participants (92%). Between 33%-66% of participants merited outreach each month, and clinician outreach required a median of 10 minutes per event. RPM was reported to be helpful by 94% of participants. RPM was associated with a GMI change of -0.25% (P=0.047) for the entire cohort, and stratified analysis revealed greatest treatment effects among participants with baseline GMI of 8.0-9.4% (GMI change of -0.68%, P=0.047; 19.84% reduction in time spent >250 mg/dl, P=0.005).

Conclusions

This study demonstrates the feasibility of RPM for patients with T1D using a commercially available population health platform, and suggests that RPM with clinician-initiated outreach may be particularly beneficial for patients with suboptimal glycemic control at entry. However, larger randomized studies are needed to fully explore the glycemic impact of RPM.

Clinical trial registration

https://clinicaltrials.gov/ct2/show/NCT04696640, identifier NCT04696640.
Alkaline phosphatase in clinical practice in childhood: Focus on rickets
Authors: Cannalire Giuseppe , Pilloni Simone , Esposito Susanna , Biasucci Giacomo , Di Franco Anna , Street Maria Elisabeth
Published: February 2023

Serum alkaline phosphatase (ALP) and its isoenzymes reflect bone metabolism: ALP increases the ratio of inorganic phosphate to pyrophosphate systemically and facilitates mineralization as well as reduces extracellular pyrophosphate concentration, an inhibitor of mineral formation. On the contrary, low ALP activity is associated with reduction of bone turnover. ALP includes four isoenzymes depending on the site of tissue expression: intestinal ALP, placental ALP, germ cell ALP and tissue nonspecific ALP or liver/bone/kidney ALP. The bone isoenzyme (B-ALP) is involved in bone calcification and is a marker of bone turnover as a result of osteoblastic activity. ALP and its isoenzymes are crucial in the diagnostic process of all the forms of rickets.The most common cause of rickets is vitamin D nutritional deficiency. The aim of this review is to update on the role played by ALP serum concentrations as a relevant marker in thediagnosis and treatment of rickets. Indeed, the diagnosis of rickets is based on its clinical, radiological and laboratory characteristics. An elevated ALP level is one of the markers for the diagnosis of rickets in children, though it is also associated with bone formation process. ALP is also useful for the differentiation between rickets and other disorders that can mimic rickets because of their clinical and laboratory characteristics, and, together with other biochemical markers, is crucial for the differential diagnosis of the different forms of rickets. Age, severity and duration of rickets may also modulate ALP elevation. Finally, ALP measurements are useful in clinical and therapeutic follow-up.
Spatial structure and influencing factors of regional city supply networks in manufacturing: A case study of Shandong, China
Authors: Yan Yiran , Wang Xingping , Zhao Sidong , Zhang Yang
Published: February 2023

COVID-19 has driven the formation of regional supply chains. In addition, cities became the basic units of intra-regional supply chain organization under urban administrative economies. Based on the data mining of the buyer-supplier relationship of listed manufacturing firms, this study explores the spatial characteristics of city supply networks within Shandong by the indexes of degree centrality, closeness centrality, betweenness centrality, eigenvector centrality, and a community detection algorithm using the social network analysis (SNA) method and ArcGIS software. It investigates the influencing factors of city supply networks by the correlation and regression of the quadratic assignment procedure (QAP). The results show the following: 1) Shandong has formed a multi-center city supply network with Jinan, Qingdao, Yantai-Weihai, and the distribution pattern of city centrality measured by different centrality indicators shows differences. 2) Cities belonging to the same network community show a coexistence of spatial proximity and “enclave” distribution. 3) Geographic proximity, convenient transportation links, administrative district economy, similarity of business environments represented by development zones, export-oriented or domestic market-oriented division of labor between cities, value chain division of labor between cities, and land price differences between cities promote the formation of regional city supply networks. Conversely, differences in local market size and wage levels between cities hinder the formation of city supply networks. This study attempts to apply the analysis results to regional planning from the perspective of regional industrial synergy development. Additionally, as it is based on typical Chinese provinces, it can provide policy references for national administrative regions and countries/regions at similar spatial scales for manufacturing supply chains, as well as for regional spatial layout decisions of manufacturing enterprises.
Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk
Authors: Bieuville Margaux , Faugère Dominique , Galibert Virginie , Henard Morgane , Dujon Antoine M. , Ujvari Beata , Pujol Pascal , Roche Benjamin , Thomas Frédéric
Published: February 2023

It is increasingly thought that part of human susceptibility to cancer is the result of evolutionary mismatches: our ancestors evolved cancer suppression mechanisms in a world largely different from our modern environments. In that context, it has been shown in cohorts from general Western populations that reproductive traits modulate breast cancer risk. Overall, the more menses women experience, the more at risk they are to develop postmenopausal breast cancer. This points towards an evolutionary mismatch but brings the question whether the reproductive pattern also modulates the breast cancer risk in menopausal women at high familial risk. We thus studied the influence of menses on breast cancer risk in a case–control study of 90 postmenopausal women (including BRCA1/2 and non BRCA1/2) nested within a cohort at high familial risk. We tested the association of the lifetime number of menses and the number of menses before first full-term pregnancy with postmenopausal breast cancer risk using Cox survival models. We showed that the total lifetime number of menses was significantly associated with postmenopausal breast cancer risk and associated with a quicker onset of breast cancer after menopause. Those results align with similar studies lead in general cohorts and suggest that the reproductive pattern modulates the familial risk of developing breast cancer after menopause. Altogether, those results impact how we envision breast cancer prevention and call for more research on how ecological and genetic factors shape breast cancer risk.
Case Report: A novel mutation in WFS1 gene (c.1756G>A p.A586T) is responsible for early clinical features of cognitive impairment and recurrent ischemic stroke
Authors: Chen Yuan , Zhang Miao , Zhou Yuying , Li Pan
Published: February 2023

Wolfram syndrome 1 (WFS1) gene mutations can be dominantly or recessively inherited, and the onset of the clinical picture is highly heterogeneity in both appearance and degree of severity. Different types of WFS1 mutations have been identified. Autosomal recessive mutations in the WFS1 gene will underlie Wolfram syndrome 1 (WS1), a rare and severe neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and other neurological, urological and psychiatric abnormalities. Other WFS1-related disorders such as low-frequency sensorineural hearing impairment (LFSNHI) and Wolfram syndrome-like disease with autosomal dominant transmission have been described. It is difficult to establish genotype-phenotype correlations because of the molecular complexity of wolframin protein. In this report, we presented a case of WSF1 gene mutation-related disease with cognitive impairment as the initial symptom and recurrent cerebral infarction in the course of the disease. Brain structural imaging results suggested decreased intracranial volume, dramatically reduced in cerebral cortex and cerebellum regions. Multimodal molecular imaging results suggested Tau protein deposition in the corresponding brain regions without Aβ pathology changes. These pathological changes may indicate a role of WFS1 in neuronal vulnerability to tau pathology associated with neurodegeneration and ischemia-induced damage.
Analysis of bulk RNA-seq data from sepsis patients reveals sepsis-associated lncRNAs and targeted cell death-related genes contributing to immune microenvironment regulation
Authors: Cheng Yanwei , Xu Lijun , Wang Jiaoyang , Cao Xue , Chen Dong , Zhang Peirong , Yang Lei , Qin Lijie
Published: February 2023

Background

Sepsis is a life-threatening organ dysfunction syndrome that leads to the massive death of immune cells. Long non-coding RNAs (lncRNAs) have been reported to exert key regulatory roles in cells. However, it is unclear how lncRNAs regulate the survival of immune cells in the occurrence and development of sepsis.

Methods

In this study, we used blood whole transcriptome sequencing data (RNA-seq) from normal controls (Hlty) and patients with uncomplicated infection (Inf1 P), sepsis (Seps P), and septic shock (Shock P), to investigate the fraction changes of immune cell types, expression pattern of cell death-related genes, as well as differentially expressed lncRNAs. Association network among these factors was constructed to screen out essential immune cell types, lncRNAs and their potential targets. Finally, the expression of lncRNAs and cell death genes in sepsis patients were validated by qRT-PCR.

Results

In this study, we found fifteen immune cell types showed significant fraction difference between Hlty and three patient groups. The expression pattern of cell death-related genes was also dysregulated in Hlty compared with patient groups. Co-expression network analysis identified a key turquoise module that was associated with the fraction changes of immune cells. We then identified differentially expressed lncRNAs and their potential targets that were tightly associated with the immune cell dysregulation in sepsis. Seven lncRNAs, including LINC00861, LINC01278, RARA-AS1, RP11-156P1.3, RP11-264B17.3, RP11-284N8.3 and XLOC_011309, as well as their co-expressed cell death genes, were finally identified, and we validated two lncRNAs (LINC00861 and LINC01278) and four mRNA targets using qRT-PCR in sepsis samples.

Conclusion

The global analysis of cell death-related genes in the occurrence and development of sepsis was carried out for the first time, and its expression regulation mode was displayed. The expression pattern of sepsis-associated lncRNAs were analyzed and identified, and the lncRNAs were significantly related to the change of immune cell proportion. We highlight the important roles of lncRNAs and their potential targets in the regulation of immune cell fraction changes during sepsis progression. The identified lncRNAs and their target genes may become new biomarkers and therapeutic targets of sepsis.