bluuebunny/crossref_metadata_2025 huggingface dataset:
Aging T cells portend poor outcome in follicular lymphoma
Authors: Zeng Hu
Published: March 2019

Immune cell profiling identifies intratumoral T cell subsets associated with patient survival in follicular lymphoma.
Onward and [K
+
]Upward: a New Potassium Importer under the Spell of Cyclic di-AMP
Authors: Pham Huong Thi , Turner Mark S.
Published: March 2019

Cyclic di-AMP (c-di-AMP) is a second messenger which plays a major role in osmotic homeostasis in bacteria. In work by Quintana et al. (I.
Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy
Authors: Rahim Yasmin , Tareen Farrukh Zia , Ahmed Rashida , Khan Javaid Ahmed
Published: March 2019

Extramedullaryplasmacytoma (EMP) represents a peculiar and typically progressive malignancy that can originate outside the bone marrow. Primary pulmonary plasmacytoma (PPP) is a rare subset of EMP, confined to the lung. A 55-year-old man, diabetic, non-smoker presented to our clinic with a right chest wall swelling. A routine chest radiograph showed a well-circumscribed opacity in the right upper lung zone. A CT of the chest revealed a large right upper lobe mass with extensive local infiltration. Biopsy and immunohistochemical evaluation led to a diagnosis of PPP. Screening for multiple myeloma was negative. Serum immunofixation showed an IgG lambda monoclonal gammopathy, found in a minority of PPP patients. In view of disease extent, treatment with chemotherapy and radiotherapy was initiated. The patient is currently in out patient follow-up and has shown a favourable response to the treatment with a considerable decrease in serum IgG levels.
Sudden death due to pulmonary embolism after minor ankle surgery
Authors: Mukhtar Maryam , Hamid Mohsin , Khan Muhammad Atique Alam , Ullah Waqas
Published: March 2019

Venous thromboembolism prophylaxis guidelines are clear for major orthopaedic surgeries, but data regarding ankle surgery are insufficient. Death from pulmonary embolism (PE) after ankle surgery is rare with the frequency of less than 0.037%.1We present a case of a fatal PE after ankle surgery to raise awareness about this rare but potentially fatal complication. Our patient had a left ankle fracture status postsurgical fixation and was discharged without venous thromboembolism (VTE) prophylaxis. Twenty days later, she presented with a sudden onset of dyspnoea and palpitations and was diagnosed to have extensive right-sided PE. Intravenous heparin and thrombolytics were given, but she had multiple pulseless electrical activity arrests, developed disseminated intravascular coagulation and died. Our case depicts an unusual complication of ankle surgery and highlights the importance of considering VTE as one of the complications. Medical personnel should evaluate the need for VTE prophylaxis after ankle surgery on a case to case basis.
Visual loss in giant cell arteritis 3 weeks after steroid initiation
Authors: Le Goueff Anouk , Peters James , Willcocks Lisa , Jayne David
Published: March 2019

Giant cell arteritis (GCA) is the most common vasculitis in adults and blindness is a common complication if left untreated. Oral glucocorticoids are the mainstay of treatment and if started promptly, loss of vision can usually be prevented. We present the case of a 77-year-old man who developed irreversible bilateral blindness after a confirmed diagnosis of GCA and oral steroid treatment. The roles of diagnostic delay, steroid dosing, significance of visual symptoms at diagnosis and after commencing oral glucocorticoids, and interpretation of ophthalmological signs are reviewed.
Severe tooth loss secondary to orofacial dyskinesias in anti-NMDA receptor encephalitis
Authors: Di Luca Daniel Garbin , Margolesky Jason H
Published: March 2019

A 24-year-old woman with no significant medical or psychiatric history was brought to the emergency department due to altered mental status and bizarre behaviour. Physical examination was remarkable for decreased speech output and orofacial dyskinesia. Upon further evaluation, electroencephalogram showed extreme delta brush waves and cerebrospinal fluid was positive for anti-NMDA receptor antibodies. Despite aggressive treatment with steroids and immunosuppressive therapy, her dyskinesia was severe enough to cause tooth loss, tongue and lip laceration.
Pseudo to pseudo connection: pseudoaneurysm draining into the pseudocyst causing pseudohaemobillia
Authors: Ullah Waqas , Hamid Mohsin , Sarwar Usman , Mehmood Asif
Published: March 2019

Haemosuccus pancreaticus (HP) is an exceedingly rare cause of lower gastrointestinal (GI) bleed where pseudoaneurysm of the peripancreatic vessels ruptures into a pancreatic pseudocyst and blood travel through the pancreatic duct, thereby, draining into GI tract via the ampulla of Vater.1We present a case of 65-year-old African-American woman with a history of alcohol abuse presented with melena for 1 day. The contrast-enhanced CT of abdomen/pelvis showed peripancreatic vascular pseudoaneurysm with active haemorrhage. Angiography confirmed the diagnosis of HP and successful transcatheter embolisation was performed.
Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank
Authors: Luo Shan , Au Yeung Shiu Lun , Zhao Jie V , Burgess Stephen , Schooling C Mary
Published: March 2019

Objective

To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction.

Design

Two sample mendelian randomisation study using genetic variants as instrumental variables, randomly allocated at conception, to infer causality as additional randomised evidence.

Setting

Reduction by Dutasteride of Prostate Cancer Events (REDUCE) randomised controlled trial, UK Biobank, and CARDIoGRAMplusC4D 1000 Genomes based genome wide association study.

Participants

3225 men of European ancestry aged 50-75 in REDUCE; 392 038 white British men and women aged 40-69 from the UK Biobank; and 171 875 participants of about 77% European descent, from CARDIoGRAMplusC4D 1000 Genomes based study for validation.

Main outcome measures

Thromboembolism, heart failure, and myocardial infarction based on self reports, hospital episodes, and death.

Results

Of the UK Biobank participants, 13 691 had thromboembolism (6208 men, 7483 women), 1688 had heart failure (1186, 502), and 12 882 had myocardial infarction (10 136, 2746). In men, endogenous testosterone genetically predicted by variants in the
JMJD1C
gene region was positively associated with thromboembolism (odds ratio per unit increase in log transformed testosterone (nmol/L) 2.09, 95% confidence interval 1.27 to 3.46) and heart failure (7.81, 2.56 to 23.8), but not myocardial infarction (1.17, 0.78 to 1.75). Associations were less obvious in women. In the validation study, genetically predicted testosterone (based on
JMJD1C
gene region variants) was positively associated with myocardial infarction (1.37, 1.03 to 1.82). No excess heterogeneity was observed among genetic variants in their associations with the outcomes. However, testosterone genetically predicted by potentially pleiotropic variants in the
SHBG
gene region had no association with the outcomes.

Conclusions

Endogenous testosterone was positively associated with thromboembolism, heart failure, and myocardial infarction in men. Rates of these conditions are higher in men than women. Endogenous testosterone can be controlled with existing treatments and could be a modifiable risk factor for thromboembolism and heart failure.
UK TAVI registry
Authors: Ludman Peter F
Published: March 2019

The UK Transcatheter Aortic Valve Implantation (TAVI) registry has collected data about every TAVI procedure performed in the UK. The latest data are from 2016 when 3250 procedures (49.5 pmp) were performed. There has been no change in the mean age of patients but there has been a shift to lower risk with fall in mean Logistic Euroscore since 2012. The switch from general anaesthetic to conscious sedation has been rapid, and propensity-adjusted analysis has not shown a difference in outcomes. In-hospital mortality has fallen to 1.8% in 2016, and relative survival analysis has shown outcome the same as the matched general population to 3 years. The UK TAVI registry has provided valuable benchmarks, and a risk adjustment model that includes frailty measures has been successfully developed and is available online.
Sutureless aortic valve prostheses
Authors: Bilkhu Rajdeep , Borger Michael A , Briffa Norman Paul , Jahangiri Marjan
Published: March 2019

Conventional surgical aortic valve replacement (AVR) is the ‘gold standard’ for treatment of severe or symptomatic aortic valve stenosis. The increasing age of patients and increasing comorbidities has led to the development of procedures to minimise operative time and reduce risks of surgery. One method of reducing operative times is the use of sutureless aortic valves (SU-AVR). We examine the current literature surrounding the use of SU-AVR. Alternatives to AVR are SU-AVR, sometimes referred to as rapid deployment valves, or transcatheter aortic valve implantation (TAVI). TAVI has been demonstrated to be superior over medical therapy in patients deemed inoperable and non-inferior in high and intermediate-risk patients compared with surgical AVR. However, the lack of excision of the calcified aortic valve and annulus raises concerns regarding long-term durability and possibly thromboembolic complications. TAVI patients have increased rates of paravalvular leaks, major vascular complications and pacemaker implantation when compared with conventional AVR. SU-AVR minimises the need for suturing, leading to reduced operative times, while enabling complete removal of the calcified valve. The increase in use of SU-AVR has been mostly driven by minimally invasive surgery. Other indications include patients with a small and/or calcified aortic root, as well as patients requiring AVR and concomitant surgery. SU-AVR is associated with decreased operative times and possibly improved haemodynamics when compared with conventional AVR. However, this has to be weighed against the increased risk of paravalvular leak and pacemaker implantation when deciding which prosthesis to use for AVR.
Patient-specific computer simulation for transcatheter cardiac interventions: what a clinician needs to know
Authors: de Jaegere Peter , Rocatello Giorgia , Prendergast Bernard D , de Backer Ole , Van Mieghem Nicolas M , Rajani Ronak
Published: March 2019

Patient-specific computer simulation consists of the assessment of the interaction of the device with the host based on the integration of the detailed geometric and biomechanical properties of the device and host. Hence, it allows the prediction of valve performance (efficacy) and complications (safety) and may consequently help the physician to select the valve/device that best fits the individual patient, thereby improving outcome. There is currently little awareness and information in clinical medicine on patient-specific computer simulation. In this paper, we describe the technical background and a number of illustrations to illustrate how patient-specific computer simulation may be used for catheter-based treatment planning of acquired heart disease.
Patient-prosthesis mismatch following aortic valve replacement
Authors: Bilkhu Rajdeep , Jahangiri Marjan , Otto Catherine M
Published: March 2019

Patient-prosthesis mismatch (PPM) occurs when an implanted prosthetic valve is too small for the patient; severe PPM is defined as an indexed effective orifice area (iEOA) <0.65 cm2/m2following aortic valve replacement (AVR). This review examines articles from the past 10 years addressing the prevalence, outcomes and options for prevention and treatment of PPM after AVR. Prevalence of PPM ranges from 8% to almost 80% in individual studies. PPM is thought to have an impact on mortality, mainly in patients with severe PPM, although severe PPM accounts for only 10–15% of cases. Outcomes of patients with moderate PPM are not significantly different to those without PPM. PPM is associated with higher rates of perioperative stroke and renal failure and lack of left ventricular mass regression. Predictors include female sex, older age, hypertension, diabetes, renal failure and higher surgical risk score. PPM may be a marker of comorbidity rather than a risk factor for adverse outcomes. PPM should be suspected in patients with persistent cardiac symptoms after AVR when there is high prosthetic valve velocity or gradient and a small calculated effective orifice area. After exclusion of other causes of increased transvalvular gradient, re-intervention may be considered if symptoms persist and are unresponsive to medical therapy. However, this decision needs to consider the available options to relieve PPM and whether expected benefits justify the risk of intervention. The only effective intervention is redo surgery with implantation of a larger valve and/or annular enlargement. Therefore, focus needs to be on prevention.
PD-L1 expression on routine samples of non-small cell lung cancer: results and critical issues from a 1-year experience of a centralised laboratory
Authors: Vigliar Elena , Malapelle Umberto , Iaccarino Antonino , Acanfora Gennaro , Pisapia Pasquale , Clery Eduardo , De Luca Caterina , Bellevicine Claudio , Troncone Giancarlo
Published: March 2019

Aims

Our laboratory is a centralised centre receiving routine non-small cell lung cancer (NSCLC) samples for programmed death ligand-1 (PD-L1) immunohistochemical (IHC) evaluation. Since literature data are not concordant here we review our clinical records to assess the rate of PD-L1 positive and negative NSCLC cases in real-world practice.

Methods

PD-L1 expression was evaluated by a validated 22C3 IHC laboratory developed test on 211 prospectively collected routine NSCLC samples, received from 10 outside institutions. PD-L1 expression was assessed by the tumour proportion score (TPS) and reported by using a three cut-point system: TPS<1, TPS 1%–49% and TPS≥50%.

Results

Overall, 193 out of 211 samples (91.5%) meet the criteria for adequacy (more than 100 viable neoplastic cells). In 62.7% (121/193) of samples TPS was <1%; 17.6% of samples (34/193) expressed PD-L1 with a TPS of 1%–49% and 19.7% (38/193) with a TPS of >50%. There was no significant difference in PD-L1 expression rates between different histotypes and site of sampling. Instead, a statistically significant difference was associated to the type of samples: in fact, cytological samples were more frequently negative for PD-L1 expression (TPS<1%) and less often displayed PD-L1 expression at high levels (TPS>50%) than surgical resections and biopsies.

Conclusions

We present a referral laboratory experience on IHC PD-L1 expression of prospectively collected routine NSCLC samples. Data from the real-world practice can better clarify the percentage of PD-L1 positive and negative cases, to establish benchmarks for good practice standards.
Smoking and hospitalisation: harnessing medical ethics and harm reduction
Authors: Sue Kimberly , Applewhite Dinah
Published: March 2019

As resident physicians practicing Internal Medicine in hospitals within the USA, we are confronted on a daily basis with patients who wish to leave the hospital floor to smoke a cigarette. While many physicians argue that hospitals should do everything in their power to prevent patients from smoking, we argue that a more comprehensive and nuanced approach is needed. In part 1 of this perspective piece, we outline the various forms of smoking bans in hospital settings, applauding the development of indoor smoking bans while questioning the move towards stricter, campus-wide smoking bans. In part 2, we turn to traditional biomedical ethics to guide our approach to the hospitalised patient who smokes. This approach, which is informed by our backgrounds in harm reduction and medical anthropology, takes into account the lived realities of patients and acknowledges the complicated sociohistorical contexts of tobacco use.
Incidence of anti‐Der f 2 and anti‐Zen 1‐specific immunoglobulin E antibodies in atopic dogs from South‐East England
Authors: Patel Anita , Curtis Cathy F , Cerundolo Rosario
Published: March 2019

Recent studies from North America and continental Europe have reported Zen 1 as a major allergen in atopic dogs, and Der f 2 as a minor allergen. In contrast, Der f 2 is considered a major allergen in Japan. In this study, allergen‐specific IgE against Der f 2, Zen 1 and crude Dermatophagoides farinae (DF) was determined using ELISA assays in English atopic dogs. Serum samples were obtained from 59 dogs with non‐seasonal atopic dermatitis. ELISA assays using horseradish peroxidase‐labelled anti‐dog IgE monoclonal antibody (Bethyl; A40‐125P) and recombinant Der f 2 (Zenoaq), natural Zen 1 (Zenoaq) and DF extract (Greer Laboratories; North Carolina) were performed by Zenoaq, Fukushima, Japan. The mean optical density (OD) of each sample was determined and the cut‐off value was calculated from OD readings obtained from four healthy control dogs. Der f 2, Zen 1 and DF‐specific IgE antibodies were found in the serum samples taken from 57 (97 per cent), 45 (76 per cent) and 47 (80 per cent) atopic dogs, respectively, suggesting that both Zen 1 and Der f 2 are ‘major allergens’ in the South‐East England.
Bluetongue virus detection in new Culicoides species in Sardinia, Italy
Authors: Foxi Cipriano , Meloni Giorgio , Puggioni Giantonella , Manunta Daniela , Rocchigiani Angelamaria , Vento Luigi , Cabras Pierangela , Satta Giuseppe
Published: March 2019

Bluetongue is an infectious disease transmitted by Culicoides biting midges. Culicoides imicola is considered the main vector in the Mediterranean basin but other species have been implicated in the Bluetongue virus (BTV) transmission. During 2017, BTV serotype 4 re‐occurred in Sardinia causing outbreaks in sheep farms. A survey was carried out on affected farms with the aim to detect the virus in field‐collected Culicoides. Biting midges were morphologically identified, pooled and then assayed with a real time RT‐PCR. To evaluate BTV dissemination, some Culicoides were dissected and head, thorax and abdomen were tested singly by PCR. A total of 173,738 Culicoides adults were collected. Viral RNA was detected in 68 out of 77 pools and all species analysed resulted positive. Detection of BTV in parous female body regions (head, thorax and abdomen) confirmed the full dissemination of BTV in all species analysed. During this study, the vector competence of C imicola, C newsteadi s.l. and Obsoletus complex was confirmed. The authors found two new Culicoides species BTV positive, C paolae never associated with BTV transmission and C circumscriptus only recently found BTV positive in Turkey, which could be considered potential vectors.
Model for planning and controlling the delivery and assembly of engineer-to-order prefabricated building systems: exploring synergies between Lean and BIM
Authors: Bataglin Fernanda S. , Viana Daniela D. , Formoso Carlos T. , Bulhões Iamara R.
Published: March 2019

The adoption of prefabricated building systems has grown due to the need to reduce duration and cost of construction projects, as well as to improve quality and working conditions. However, the adoption of those systems requires an intense exchange of information to integrate the production of components, logistics operations, and site assembly. This is particularly important in engineer-to-order environments, in which the level of uncertainty tends to be high. This research proposes a model for planning and controlling the delivery and assembly of ETO prefabricated building systems, emphasizing the integration between site installation and logistics operations. This model was devised in an empirical study carried out in a company that delivers and assembles prefabricated concrete structures. The main theoretical contribution is a set of approaches to implement the “pull production” and “reduce variability” principles in this particular context, exploring synergies that exist between Lean Production principles and Building Information Modeling (BIM) functionalities.
Thickness dependence of AC conductivity in TlSe thin films
Authors: Saglam Ugur , Yakut Sahin , Karabak Binnur , Bozoglu Deniz
Published: March 2019

Thalium selenide (TlSe), which has a lattice with tetragonal symmetry, is a member of the A3B6 semiconductor group. The structure of TlSe is defined as chains where atoms inside are bonded with an ionic-covalent bond. TlSe thin films were deposited by thermal evaporation under a high vacuum on glass substrates. The structure of TlSe thin films is amorphous with a tetragonal structure. The AC conductivity measurements were operated via the measurements of capacitance and dielectric dissipation (tanδ) at room temperature. AC conductivity values change between 10−11 and 10−6 S/cm at the low-frequency side with decreasing thickness. Two different conduction regions were observed with increasing frequency. The region observed at the low-frequency side can be attributed to the motion of a chain-like part of the lattice, while the region observed at the high-frequency side can be attributed to side groups.
One-loop correction to Z → νν in the minimal R-symmetric supersymmetric Standard Model
Authors: Sun Ke-Sheng , Chen Jian-Bin , Yang Xiu-Yi , Zhang Hai-Bin
Published: March 2019

We analyze the one-loop correction to [Formula: see text] decay in framework of Minimal R-symmetric Supersymmetric Standard Model (MRSSM) in detail with normal and inverse neutrino mass orderings, as a function of [Formula: see text], Dirac mass parameters [Formula: see text] and [Formula: see text], slepton mass [Formula: see text] that parametrize the mass matrices. The numerical results indicate that the branching ratio for [Formula: see text] decay is compatible with the experimental measurement and the SM expectation at [Formula: see text] level. For inverse neutrino mass ordering, the prediction exceeds the SM expectation at [Formula: see text] level. The prediction on [Formula: see text] increases proportionally to [Formula: see text] and inversely proportionally to [Formula: see text]. For normal neutrino mass ordering, the peak value of the prediction on [Formula: see text] exceeds the SM expectation at [Formula: see text] level.
A multi-parameter integrated chip system for water quality detection
Authors: Wang Jiaqi , Bian Chao , Li Yang , Sun Jizhou , Tong Jianhua , Xia Shanhong
Published: March 2019

Water pollution has always been an important issue threatening human health. Water quality monitoring is an important step to ensure water quality safety. Water quality parameters such as pH, temperature and conductivity are important indicators in water quality monitoring. In this paper, a multi-parameter water quality detection integrated chip system is studied, and multiple sensors are integrated on the same chip to realize the monitoring of conventional parameters such as pH, temperature and conductivity in drinking water. The chip system was processed by MEMS technology. A ruthenium oxide (RuO2) film is used for pH detection, and the sensor exhibits a super-Nernst response (62.88 mV/pH) in the range of pH 1.92–11.74. The patterned micro Pt film is used as the temperature sensor, and the three-wire orthogonal structure is used for temperature detection. The sensitivity of this temperature sensor is 5.517 [Formula: see text]/[Formula: see text]C in the range of 6 to 80[Formula: see text]C. Conductivity was measured by a four-electrode system, and the electrode constant was 1.667 cm[Formula: see text] measured between 0.994 and 21.167 mS/cm. The test results show that the multi-parameter integrated chip system can realize the simultaneous detection of pH, temperature and conductivity in water, and has the characteristics of miniaturization and low cost, and provides an effective way for simultaneous detection of water quality.
k-DDD Measure and MapReduce Based Anonymity Model for Secured Privacy-Preserving Big Data Publishing
Authors: Madan Suman , Goswami Puneet
Published: March 2019

Nowadays, big data publishing is the emerging trend since they have good potential for the decision support in the applications, such as a hospital, government, industries, etc. Existing algorithms have many problems in preserving the privacy of the data when the data is in large size. To avoid these problems, this paper introduces a novel anonymity model for the data publishing based on K-DDD measure and MapReduce. This paper presents the Duplicate-Divergence-Different properties enabled dragon Genetic (DDDG) algorithm based on the k-DDD anonymization and the dragon operator based genetic algorithm. The proposed DDDG algorithm allows the privacy preservation in the big data by modifying the MapReduce techniques with the proposed DDDG algorithm. The performance of the proposed anonymity model is analyzed with the metrics such as information loss (IL) and the classification accuracy (CA). The adult database from the UC Irvine dataset is used for the simulation. The simulation results show that the proposed DDDG algorithm achieved the lowest IL of 0.0191 and the highest CA with the value of 0.8977 than the existing algorithms for k value of 2.
Particle Grey Wolf Optimizer (PGWO) Algorithm and Semantic Word Processing for Automatic Text Clustering
Authors: Vidyadhari Ch. , Sandhya N. , Premchand P.
Published: March 2019

Text mining refers to the process of extracting the high-quality information from the text. It is broadly used in applications, like text clustering, text categorization, text classification, etc. Recently, the text clustering becomes the facilitating and challenging task used to group the text document. Due to some irrelevant terms and large dimension, the accuracy of text clustering is reduced. In this paper, the semantic word processing and novel Particle Grey Wolf Optimizer (PGWO) is proposed for automatic text clustering. Initially, the text documents are given as input to the pre-processing step which caters the useful keyword for feature extraction and clustering. Then, the resultant keyword is applied to wordnet ontology to find out the synonyms and hyponyms of every keyword. Subsequently, the frequency is determined for every keyword which is used to build the text feature library. Since the text feature library contains the larger dimension, the entropy is utilized to select the most significant feature. Finally, the new algorithm Particle Grey Wolf Optimizer (PGWO) is developed by integrating the particle swarm optimization (PSO) into the grey wolf optimizer (GWO). Thus, the proposed algorithm is used to assign the class labels to generate the different clusters of text documents. The simulation is performed to analyze the performance of the proposed algorithm, and the proposed algorithm is compared with existing algorithms. The proposed method attains the clustering accuracy of 80.36% for 20 Newsgroup dataset and the clustering accuracy of 79.63% for Reuter which ensures the better automatic text clustering.
A New Type 2 Fuzzy Time Series Forecasting Model Based on Three-Factors Fuzzy Logical Relationships
Authors: Abhishekh  , Gautam Surendra Singh , Singh Shiva Raj
Published: March 2019

The study of fuzzy time series models have been extensively used to improve the accuracy rates in forecasting problems. In this paper, we present a new type 2 fuzzy time series forecasting model based on three-factors fuzzy logical relationship groups. The proposed method uses a new technique to define partitions the universe of discourse into different length of intervals for different factors. Also, the proposed method fuzzifies the historical data sets of the main factors, second factors and third factors to their maximum membership grades obtained by their corresponding triangular fuzzy sets and construct the fuzzy logical relationship groups which is based on the three-factors to enhance in the forecasting accuracy rates. This paper introduces a new defuzzification technique based on their frequency occurrences of fuzzy logical relationships in fuzzy logical relationship groups. The fitness of the propose method is verified in the forecasting of Bombay Stock Exchange (BSE) Sensex historical data and compare in terms of root mean square and average forecasting errors which indicates that the proposed method produce more accurate forecasted output over the existing models in fuzzy time series.
The Distributivity Equations of Semi-Uninorms
Authors: Su Yong , Liu Hua-Wen , Pedrycz Witold
Published: March 2019

Distributivity between two operations is a property posed many years ago — that is especially interesting in the framework of logical connectives because of its applications to fuzzy logic and approximate reasoning as their applications. Since semi-uninorms have been used in these topics, the study of the distributivity between two semi-uninorms becomes of particular interest that calls for thorough studies. The distributivity between two semi-uninorms, which are non-commutative and non-associative uninorms, has been developed only in the cases when both semi-uninorms are examples of very special classes of semi-uninorms. On the other hand, in general, the distributivity does not rely on the commutativity and associativity. The objective of this work is twofold. The first one is to show new solutions to distributivity equations for semi-uninorms. The second one is to check whether the results concerning the distributivity between two uninorms are valid for semi-uninorms. We investigate the distributivity involving two semi-uninorms when only one semi-uninrom lies in the most studied classes of semi-uninorms, achieving the above two objectives simultaneously.
Structural, Morphological, Magnetic and Self-Heating Studies of One-Step Polyol Synthesized Manganese Ferrite (MnFe2O4) Nanoparticles
Authors: Ghutepatil P. R. , Pawar S. H.
Published: March 2019

In this paper, uniform and superparamagnetic nanoparticles have been prepared using one-step polyol synthesis method. Structural, morphological and magnetic properties of obtained MnFe2O4 nanoparticles have been investigated by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscope (FE-SEM), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM) and thermogravimetric analysis (TGA) techniques. Structural investigation showed that the average crystallite size of obtained nanoparticles was about 10[Formula: see text]nm. Magnetic study revealed that the nanoparticles were superparamagnetic at room temperature with magnetization 67[Formula: see text]emu/g at room temperature. The self-heating characteristics of synthesized MnFe2O4 nanoparticles were studied by applying external AC magnetic field of 167.6 to 335.2[Formula: see text]Oe at a fixed frequency of 265[Formula: see text]kHz. The SAR values of MnFe2O4 nanoparticles were calculated for 2, 5, 10[Formula: see text]mg[Formula: see text]mL[Formula: see text] concentrations and it is observed that the threshold hyperthermia temperature is achieved for all concentrations.
A synchronous quantum blind signature scheme with entanglement swapping
Authors: Fan Ling , Cao Cong
Published: March 2019

We present an arbitrated quantum blind signature scheme by entanglement swapping, which is simplified from the preparation and operation of the quantum states. Compared with the classical blind signature, quantum arbitration has added the role of the third party arbitration, so the structure of the protocol has changed. The traceability depends on the third party arbitration, and the blind operation and the signature operation can be carried out simultaneously.
Absolutely maximally entangled states from phase states
Authors: Mansour M. , Daoud M. , Bouhouch L.
Published: March 2019

We derive absolutely maximally entangled (AME) states from phase states for a multi-qudit system whose dynamics is governed by a two-qudit interaction Hamiltonian of Heisenberg type. AME states are characterized by being maximally entangled for all bipartitions of the multi-qudit system and present absolute multipartite entanglement. The key ingredient of this approach is the theory of phase states for finite-dimensional systems (qudits). We define further the unitary phase operators of [Formula: see text]-qudit systems and we give next the corresponding separable phase states. Using a qudit–qudit Hamiltonian acting as entangling operator on separable phase states, we generate entangled phase states. Finally, from the labeled entangled phase states, we derive the absolutely maximally entangled states.
On Graphs with Three or Four Distinct Normalized Laplacian Eigenvalues
Authors: Huang Xueyi , Huang Qiongxiang
Published: March 2019

We characterize all connected graphs with exactly three distinct normalized Laplacian eigenvalues among which one is equal to 1, and determine all connected bipartite graphs with at least one vertex of degree 1 having exactly four distinct normalized Laplacian eigenvalues. In addition, we find all unicyclic graphs with three or four distinct normalized Laplacian eigenvalues.
Multiplicity-Free Gradings on Semisimple Lie and Jordan Algebras and Skew Root Systems
Authors: Han Gang , Liu Yucheng , Lu Kang
Published: March 2019

A G-grading on an algebra, where G is an abelian group, is called multiplicity-free if each homogeneous component of the grading is 1-dimensional. We introduce skew root systems of Lie type and skew root systems of Jordan type, and use them to construct multiplicity-free gradings on semisimple Lie algebras and on semisimple Jordan algebras respectively. Under certain conditions the corresponding Lie (resp., Jordan) algebras are simple. Two families of skew root systems of Lie type (resp., of Jordan type) are constructed and the corresponding Lie (resp., Jordan) algebras are identified. This is a new approach to study abelian group gradings on Lie and Jordan algebras.
Notes on Solvability andp-Supersolvability of Finite Groups
Authors: Zhang Jia , Qiu Tingting , Miao Long , Tang Juping
Published: March 2019

A subgroup H of G is called ℳ-supplemented in G if there exists a subgroup B of G such that G = HB and HiB < G for every maximal subgroup Hiof H. In this paper, we use ℳ-supplemented subgroups to study the structure of finite groups and obtain some new characterization about solvability and p-supersolvability for a fixed prime p. Some results in the literature are corollaries of our theorems.
CI-Property for Decomposable Schur Rings over an Abelian Group
Authors: Kovács István , Ryabov Grigory
Published: March 2019

A Schur ring over a finite group is said to be decomposable if it is the generalized wreath product of Schur rings over smaller groups. In this paper we establish a sufficient condition for a decomposable Schur ring over the direct product of elementary abelian groups to be a CI-Schur ring. By using this condition we offer short proofs for some known results on the CI-property for decomposable Schur rings over an elementary abelian group of rank at most 5.
Interaction between the folded structures of the Western Papua New Guinea Highlands: an example of how surface observations can assist in subsurface understanding
Authors: Ollarves Reinaldo , Zhao Siyuan , Gilby Fleur
Published: March 2019

We defined the folding sequence of the fold–thrust belt of the Western Papua New Guinea Highlands by analysing the surface expression of the structures and the response of the drainage system to the active fold–thrust belt. The interaction between structures is typically assessed by examining the syn-kinematic strata preserved; however, in our study area, this is problematic as these strata are poorly imaged on seismic lines. This study found common morphological features that allowed grouping and mapping of three different structural settings: group I, basement-involved tectonics; group II, thin-skinned anticlines which sole near the Koi–Iangi Sandstone; and group III, thin-skinned folds associated with the intra-Ieru Formation detachment. Fold Front Sinuosity analysis supports the idea that the fold–thrust belt propagates from the NW to the SE. Considering the detailed morphotectonics and drainage analyses, we interpret that the group II folds developed as out-of-sequence thrusting and folding, associated with buttressing against the group I larger structures.
Variation in syn-subduction sedimentation patterns from inner to outer portions of deep-water fold and thrust belts: examples from the Hikurangi subduction margin of New Zealand
Authors: McArthur A. D. , Claussmann B. , Bailleul J. , Clare A. , McCaffrey W. D.
Published: March 2019

The structure and distribution of accommodation in fold and thrust belts vary both laterally and longitudinally. Here we integrate gravity, bathymetry and 2D seismic datasets to investigate the structural and stratigraphic variation in the southern part of the Hikurangi subduction wedge, onshore and offshore North Island, New Zealand. Three morphostructural portions are recognized:

The inner portion demonstrates reactivation of inherited structures, producing thick-skinned deformation. Pre-subduction rocks are represented by kilometres of acoustically chaotic seismofacies. Thick-skinned deformation and readily deformable substrate lead to the development of wide trench-slope sub-basins, infilled with >5 km of syn-subduction sediments.

The mid portion typically demonstrates thrust faults with connections to deeper structures, leading to the development of an imbricate system with asymmetrical sub-basins typically <5 km thick developed on the back-limb of thrust related folds.

An antiformal stack marks the transition from the thick-skinned interior of the basin to the thin-skinned accretionary prism. Beyond this, the relatively non-deformed outer portion demonstrates frontal folds, propagating thrusts and up to 3 km thickness of syn-subduction strata.

Structural variation across the subduction wedge controls the generation of accommodation with implications for sediment distribution within fold and thrust belts and for petroleum system development.
Temporal Relational Ranking for Stock Prediction
Authors: Feng Fuli , He Xiangnan , Wang Xiang , Luo Cheng , Liu Yiqun , Chua Tat-Seng
Published: March 2019

Stock prediction aims to predict the future trends of a stock in order to help investors make good investment decisions. Traditional solutions for stock prediction are based on time-series models. With the recent success of deep neural networks in modeling sequential data, deep learning has become a promising choice for stock prediction.

However, most existing deep learning solutions are not optimized toward the target of investment, i.e., selecting the best stock with the highest expected revenue. Specifically, they typically formulate stock prediction as a classification (to predict stock trends) or a regression problem (to predict stock prices). More importantly, they largely treat the stocks as independent of each other. The valuable signal in the rich relations between stocks (or companies), such as two stocks are in the same sector and two companies have a supplier-customer relation, is not considered.

In this work, we contribute a new deep learning solution, namedRelational Stock Ranking(RSR), for stock prediction. Our RSR method advances existing solutions in two major aspects: (1) tailoring the deep learning models for stock ranking, and (2) capturing the stock relations in a time-sensitive manner. The key novelty of our work is the proposal of a new component in neural network modeling, namedTemporal Graph Convolution, which jointly models the temporal evolution and relation network of stocks. To validate our method, we perform back-testing on the historical data of two stock markets, NYSE and NASDAQ. Extensive experiments demonstrate the superiority of our RSR method. It outperforms state-of-the-art stock prediction solutions achieving an average return ratio of 98% and 71% on NYSE and NASDAQ, respectively.
Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer
Authors: Wang Kai , Baldwin Graham S. , Nikfarjam Mehrdad , He Hong
Published: March 2019

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies worldwide. All-trans retinoic acid (ATRA) has been used as an antistromal agent in PDA, and its antitumor effect has also been reported in various kinds of cancer, including PDA. Inhibition of p21-activated kinases (PAKs) is associated with decreased tumor growth and increased gemcitabine sensitivity. The aim of this study was to evaluate the inhibitory effects of ATRA alone and in combination with gemcitabine on cell growth and migration of wild-type and gemcitabine-resistant PDA cells and the potential mechanism(s) involved. Human (MiaPaCa-2) and murine (TB33117) PDA cell lines were incubated in increasing concentrations of gemcitabine to establish resistant clones. Cell growth, clonogenicity, and migration/invasion were determined using a sulforhodamine B assay, a colony formation assay, and a Boyden chamber assay, respectively. Protein expression was measured by Western blotting. ATRA reduced cell proliferation, colony formation, and migration/invasion in both wild-type and gemcitabine-resistant cell lines. PAK1 expression was significantly increased in resistant cells. Cells treated with ATRA showed decreased expression of PAK1, PAK2, PAK4, and α-smooth muscle actin. The combination of ATRA and gemcitabine synergistically reduced cell growth in both wild-type and gemcitabine-resistant cell lines. Depletion of PAK1 enhanced ATRA sensitivity in MiaPaCa-2 cells. In conclusion, the antitumor effects of ATRA and its synergism with gemcitabine are associated with downregulation of PAKs.

NEW & NOTEWORTHY The inhibitory effect of all-trans retinoic acid (ATRA) on cell proliferation, colony formation, and migration/invasion was associated with downregulation of p21-activated kinases (PAKs), and depletion of PAK1 enhanced ATRA sensitivity in MiaPaCa-2 cells. The combination of ATRA and gemcitabine synergistically reduced cell growth in both wild-type and gemcitabine-resistant pancreatic ductal adenocarcinoma cells. As an important prognostic marker, α-smooth muscle actin also can be downregulated by ATRA in pancreatic ductal adenocarcinoma cells.
Plasma free fatty acid concentration is closely tied to whole body peak fat oxidation rate during repeated exercise
Authors: Frandsen Jacob , Vest Stine Dahl , Ritz Christian , Larsen Steen , Dela Flemming , Helge Jørn W.
Published: March 2019

Plasma free fatty acids (FFA) are a major contributor to whole body fat oxidation during exercise. However, the extent to which manipulating plasma FFA concentrations will influence whole body peak fat oxidation rate (PFO) during exercise remains elusive. In this study we aimed to increase plasma FFA concentrations through a combination of fasting and repeated exercise bouts. We hypothesized that an increase in plasma FFA concentration would increase PFO in a dose-dependent manner. Ten healthy young (31 ± 6 yr) (mean ± SD) well-trained (maximal oxygen uptake 65.9 ± 6.1 ml·min−1·kg−1) men performed four graded exercise tests (GXTs) on 1 day. The GXTs were interspersed by 4 h of bed rest. This was conducted either in a fasted state or with the consumption of a standardized carbohydrate-rich meal 3.5 h before each GXT. Fasting and previous GXTs resulted in a gradual increase in PFO from 0.63 ± 0.18 g/min after an overnight fast (10 h) to 0.93 ± 0.17 g/min after ∼22 h of fasting and three previous GXTs. This increase in PFO coincided with an increase in plasma FFA concentrations ( r2 = 0.73, P < 0.0001). Ingestion of a carbohydrate-rich meal 3.5 h before each GXT resulted in unaltered PFO. This was also reflected in unchanged plasma FFA, glucose, and insulin concentrations. In this study we show that plasma FFA availability is closely tied to whole body PFO and that the length of fasting combined with previous exercise are robust stimuli toward increasing plasma FFA concentration, highlighting the importance for preexercise standardization when conducting GXTs measuring substrate oxidation.

NEW & NOTEWORTHY We show that peak fat oxidation is increased in close relationship with plasma free fatty acid availability after combined fasting and repeated incremental exercise tests in healthy highly trained men. Therefore it may be argued that whole body fat oxidation rate measured in most cases after an overnight fast indeed does not represent whole body maximal fat oxidation rate but a whole body peak fat oxidation rate within the context of the preexercise standardization obtained in the study design.
Sexual dimorphism in the control of skeletal muscle interstitial Po2 of heart failure rats: effects of dietary nitrate supplementation
Authors: Craig Jesse C. , Colburn Trenton D. , Hirai Daniel M. , Musch Timothy I. , Poole David C.
Published: March 2019

Sex differences in the mechanisms underlying cardiovascular pathophysiology of O2 transport in heart failure (HF) remain to be explored. In HF, nitric oxide (NO) bioavailability is reduced and contributes to deficits in O2 delivery-to-utilization matching. Females may rely more on NO for cardiovascular control and as such experience greater decrements in HF. We tested the hypotheses that moderate HF induced by myocardial infarction would attenuate the skeletal muscle interstitial Po2 response to contractions (Po2is; determined by O2 delivery-to-utilization matching) compared with healthy controls and females would express greater dysfunction than male counterparts. Furthermore, we hypothesized that 5 days of dietary nitrate supplementation (Nitrate; 1 mmol·kg−1·day−1) would raise Po2is in HF rats. Forty-two Sprague-Dawley rats were randomly assigned to healthy, HF, or HF + Nitrate groups (each n = 14; 7 female/7 male). Spinotrapezius Po2is was measured via phosphorescence quenching during electrically induced twitch contractions (180 s; 1 Hz). HF reduced resting Po2is for both sexes compared with healthy controls ( P < 0.01), and females were lower than males (14 ± 1 vs. 17 ± 2 mmHg) ( P < 0.05). In HF both sexes expressed reduced Po2is amplitudes following the onset of muscle contractions compared with healthy controls (female: −41 ± 7%, male: −26 ± 12%) ( P < 0.01). In HF rats, Nitrate elevated resting Po2is to values not different from healthy rats and removed the sex difference. Female HF + Nitrate rats expressed greater resting Po2is and amplitudes compared with female HF ( P < 0.05). In this model of moderate HF, O2 delivery-to-utilization matching in the interstitial space is diminished in a sex-specific manner and dietary nitrate supplementation may serve to offset this reduction in HF rats with greater effects in females.

NEW & NOTEWORTHY Interstitial Po2 (Po2is; indicative of O2 delivery-to-utilization matching) determines, in part, O2 flux into skeletal muscle. We show that heart failure (HF) reduces Po2is at rest and during skeletal muscle contractions in rats and this negative effect is amplified for females. However, elevating NO bioavailability with dietary nitrate supplementation increases resting Po2is and alters the dynamic response with greater efficacy in female HF rats, particularly at rest and following the onset of muscle contractions.