bluuebunny/crossref_metadata_2025 huggingface dataset:
Contribution of Starmerella bacillaris and Oak Chips to Trebbiano d’Abruzzo Wine Volatile and Sensory Diversity
Authors: Perpetuini Giorgia , Rossetti Alessio Pio , Battistelli Noemi , Zulli Camillo , Piva Andrea , Arfelli Giuseppe , Corsetti Aldo , Tofalo Rosanna
Published: March 2023

In this study, six fermentation trials were carried out: co-inoculation and sequential inoculation of Saccharomyces cerevisiae and Starmerella bacillaris in the presence and absence of oak chips. Moreover, Starm. bacillaris strain was attached to the oak chips and co-inoculated or sequentially inoculated with S. cerevisiae. Wines fermented with Starm. bacillaris adhered to oak chips showed a higher concentration of glycerol (more than 6 g/L) than the others (about 5 g/L). These wines also showed a higher content of polyphenols (more than 300 g/L) than the others (about 200 g/L). The addition of oak chips induced an increase of yellow color (b* value of about 3). Oak-treated wines were characterized by a higher concentration of higher alcohols, esters and terpenes. Aldehydes, phenols and lactones were detected only in these wines, independently from the inoculation strategy. Significant differences (p < 0.05) were also observed in the sensory profiles. The fruity, toasty, astringency, and vanilla sensations were perceived as more intense in wines treated with oak chips. The white flower descriptor showed a higher score in wines fermented without chips. Oak surface-adhered Starm. bacillaris cells could be a good strategy to improve the volatile and sensory profile of Trebbiano d’Abruzzo wines.
Neural Network-Based Adaptive Fractional-Order Backstepping Control of Uncertain Quadrotors with Unknown Input Delays
Authors: Yang Yi , Zhang Haiyan H.
Published: March 2023

Adaptive control is essential and effective for reliable quadrotor operations in the presence of uncertain modeling parameters and unknown time-delayed inputs. This paper presents an original radial basis function neural network-based adaptive fractional-order backstepping controller (RBF-ADFOBC). The nonlinearity of the time-delayed inputs is eliminated by introducing an augmented state variable via Pade’s approximation method. For each subsystem in the quadrotor dynamics, a companioned second-order compensation system is developed. The candidate Lyapunov functions are then properly designed by incorporating the control errors, parameter uncertainties and estimation errors of the neural networks’ weight vectors. It is shown that the semi-globally uniformly ultimately boundedness of all the state variables and the estimation error of uncertain parameters can be guaranteed. In addition, the trajectory-tracking error of the state variables can be driven to an adjustable small neighborhood of origin by properly setting the selectable parameters. Numerical simulations reveal that the tracking performance of the proposed controller can be improved continuously as the fractional order increases to a specific positive value, and the controller with a negative order may demonstrate higher robustness to the modeling uncertainties. Favorably, the comparison to the other two previous controllers further reveals the superior tracking accuracy and robustness of the proposed RBF-ADFOBC controller.
Fungal Carboxymethyl Chitosan-Impregnated Bacterial Cellulose Hydrogel as Wound-Dressing Agent
Authors: Suneetha Maduru , Won So-Yeon , Zo Sun Mi , Han Sung Soo
Published: March 2023

Bacterial cellulose (BC) produced by Gluconoacetobacter hansenii is a suitable polymeric fiber network for wound-dressing purposes, but its lack of antibacterial properties limits it from healing bacterial wounds. We developed hydrogels by impregnating fungal-derived carboxymethyl chitosan to BC fiber networks using a simple solution immersion method. The CMCS–BC hydrogels were characterized using various characterization techniques such as XRD, FTIR, water contact angle measurements, TGA, and SEM to know the physiochemical properties. The results show that the impregnation of CMCS into BC fiber networks greatly influences BC’s improving hydrophilic nature, which is crucial for wound healing applications. Furthermore, the CMCS–BC hydrogels were studied for biocompatibility analysis with skin fibroblast cells. The results revealed that by increasing the CMCS content in the BC, biocompatibility, cell attachment, and spreading capacity also increase. The antibacterial activity of CMCS–BC hydrogels is shown using the CFU method against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). As a result, the CMCS–BC hydrogels exhibit more suitable antibacterial properties than those without BC due to the CMCS having amino groups that enhance antibacterial properties. Therefore, CMCS–BC hydrogels can be considered suitable for antibacterial wound dressing applications.
Design and Evaluation of Paeonol-Loaded Liposomes in Thermoreversible Gels for Atopic Dermatitis
Authors: Wang Yu , Yue Yan , Jia Ruoyang , Liu Xinyi , Cheng Zhiqing , Cheng Yongfeng , Xu Yinxiang , Xie Zili , Xia Hongmei
Published: March 2023

Paeonol (PAE) is a hydrophobic drug. In this study, we encapsulated paeonol in a lipid bilayer of liposomes (PAE-L), which delayed drug release and increased drug solubility. When PAE-L was dispersed in gels (PAE-L-G) based on a poloxamer matrix material for local transdermal delivery, we observed amphiphilicity, reversible thermal responsiveness, and micellar self-assembly behavior. These gels can be used for atopic dermatitis (AD), an inflammatory skin disease, to change the surface temperature of the skin. In this study, we prepared PAE-L-G at an appropriate temperature for the treatment of AD. We then assessed the gel’s relevant physicochemical properties, in vitro cumulative drug release, and antioxidant properties. We found that PAE-loaded liposomes could be designed to increase the drug effect of thermoreversible gels. At 32 °C, PAE-L-G could change from solution state to gelatinous state at 31.70 ± 0.42 s, while the viscosity was 136.98 ± 0.78 MPa.S and the free radical scavenging rates on DPPH and H2O2 were 92.24 ± 5.57% and 92.12 ± 2.71%, respectively. Drug release across the extracorporeal dialysis membrane reached 41.76 ± 3.78%. In AD-like mice, PAE-L-G could also relieve skin damage by the 12th day. In summary, PAE-L-G could play an antioxidant role and relieve inflammation caused by oxidative stress in AD.
Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels
Authors: Li Rui , Zhou Qing-Ling , Tai Min-Rui , Ashton-Mourney Kathryn , Harty Mathew I. , Rifai Aaqil , Parish Clare L. , Nisbet David R. , Zhong Sai-Yi , Williams Richard J.
Published: March 2023

Bioinspired self-assembly is a bottom-up strategy enabling biologically sophisticated nanostructured biogels that can mimic natural tissue. Self-assembling peptides (SAPs), carefully designed, form signal-rich supramolecular nanostructures that intertwine to form a hydrogel material that can be used for a range of cell and tissue engineering scaffolds. Using the tools of nature, they are a versatile framework for the supply and presentation of important biological factors. Recent developments have shown promise for many applications such as therapeutic gene, drug and cell delivery and yet are stable enough for large-scale tissue engineering. This is due to their excellent programmability—features can be incorporated for innate biocompatibility, biodegradability, synthetic feasibility, biological functionality and responsiveness to external stimuli. SAPs can be used independently or combined with other (macro)molecules to recapitulate surprisingly complex biological functions in a simple framework. It is easy to accomplish localized delivery, since they can be injected and can deliver targeted and sustained effects. In this review, we discuss the categories of SAPs, applications for gene and drug delivery, and their inherent design challenges. We highlight selected applications from the literature and make suggestions to advance the field with SAPs as a simple, yet smart delivery platform for emerging BioMedTech applications.
The Klinefelter Syndrome and Testicular Sperm Retrieval Outcomes
Authors: Sá Rosália , Ferraz Luís , Barros Alberto , Sousa Mário
Published: March 2023

Klinefelter syndrome (KS), caused by the presence of an extra X chromosome, is the most prevalent chromosomal sexual anomaly, with an estimated incidence of 1:500/1000 per male live birth (karyotype 47,XXY). High stature, tiny testicles, small penis, gynecomastia, feminine body proportions and hair, visceral obesity, and testicular failure are all symptoms of KS. Endocrine (osteoporosis, obesity, diabetes), musculoskeletal, cardiovascular, autoimmune disorders, cancer, neurocognitive disabilities, and infertility are also outcomes of KS. Causal theories are discussed in addition to hormonal characteristics and testicular histology. The retrieval of spermatozoa from the testicles for subsequent use in assisted reproduction treatments is discussed in the final sections. Despite testicular atrophy, reproductive treatments allow excellent results, with rates of 40–60% of spermatozoa recovery, 60% of clinical pregnancy, and 50% of newborns. This is followed by a review on the predictive factors for successful sperm retrieval. The risks of passing on the genetic defect to children are also discussed. Although the risk is low (0.63%) when compared to the general population (0.5–1%), patients should be informed about embryo selection through pre-implantation genetic testing (avoids clinical termination of pregnancy). Finally, readers are directed to a number of reviews where they can enhance their understanding of comprehensive diagnosis, clinical care, and fertility preservation.
EGFRvIII Promotes the Proneural–Mesenchymal Transition of Glioblastoma Multiforme and Reduces Its Sensitivity to Temozolomide by Regulating the NF-κB/ALDH1A3 Axis
Authors: Shi Zhong-Fang , Li Guan-Zhang , Zhai You , Pan Chang-Qing , Wang Di , Yu Ming-Chen , Liu Chi , Zhang Wei , Yu Xiao-Guang
Published: March 2023

(1) Background: Glioblastoma multiforme (GBM) is the most common and malignant intracranial tumor in adults. At present, temozolomide (TMZ) is recognized as the preferred chemotherapeutic drug for GBM, but some patients have low sensitivity to TMZ or chemotherapy resistance to TMZ. Our previous study found that GBM patients with EGFRvIII (+) have low sensitivity to TMZ. However, the reasons and possible mechanisms of the chemoradiotherapy resistance in GBM patients with EGFRvIII (+) are not clear. (2) Methods: In this study, tissue samples of patients with GBM, GBM cell lines, glioma stem cell lines, and NSG mice were used to explore the causes and possible mechanisms of low sensitivity to TMZ in patients with EGFRvIII (+)-GBM. (3) Results: The study found that EGFRvIII promoted the proneural–mesenchymal transition of GBM and reduced its sensitivity to TMZ, and EGFRvIII regulated of the expression of ALDH1A3. (4) Conclusions: EGFRvIII activated the NF-κB pathway and further regulated the expression of ALDH1A3 to promote the proneural–mesenchymal transition of GBM and reduce its sensitivity to TMZ, which will provide an experimental basis for the selection of clinical drugs for GBM patients with EGFRvIII (+).
Identification of Selection Signatures and Loci Associated with Important Economic Traits in Yunan Black and Huainan Pigs
Authors: Han Yachun , Tan Tao , Li Zixin , Ma Zheng , Lan Ganqiu , Liang Jing , Li Kui , Bai Lijing
Published: March 2023

Henan Province is located in central China and rich in domestic pig populations; Huainan (HN) pigs are one of three Henan indigenous breeds with great performance, including early maturation, strong disease resistance and high meat quality. Yunan (YN) black pigs are a typical, newly cultivated breed, synthesized between HN pigs and American Duroc, and are subjected to selection for important traits, such as fast growth and excellent meat quality. However, the genomic differences, selection signatures and loci associated with important economic traits in YN black pigs and HN pigs are still not well understood. In this study, based on high-density SNP chip analysis of 159 samples covering commercial DLY (Duroc × Landrace × Large White) pigs, HN pigs and YN black pigs, we performed a comprehensive analysis of phylogenetic relationships and genetic diversity among the three breeds. Furthermore, we used composite likelihood ratio tests (CLR) and F-statistics (Fst) to identify specific signatures of selection associated with important economic traits and potential candidate genes. We found 147 selected regions (top 1%) harboring 90 genes based on genetic differentiation (Fst) in the YN-DLY group. In the HN-DLY group, 169 selected regions harbored 58 genes. In the YN-HN group, 179 selected regions harbored 77 genes. In addition, the QTLs database with the most overlapping regions was associated with triglyceride level, number of mummified pigs, hemoglobin and loin muscle depth for YN black pigs, litter size and intramuscular fat content for HN pigs, and humerus length, linolenic acid content and feed conversion ratio mainly in DLY pigs. Of note, overlapping 14 tissue-specific promoters’ annotation with the top Fst 1% selective regions systematically demonstrated the muscle-specific and hypothalamus-specific regulatory elements in YN black pigs. Taken together, these results contribute to an accurate knowledge of crossbreeding, thus benefitting the evaluation of production performance and improving the genome-assisted breeding of other important indigenous pig in the future.
Proteome Dynamics Analysis Reveals the Potential Mechanisms of Salinity and Drought Response during Seed Germination and Seedling Growth in Tamarix hispida
Authors: Pang Xin’an , Liu Shuo , Suo Jiangtao , Yang Tiange , Hasan Samira , Hassan Ali , Xu Jindong , Lu Sushuangqing , Mi Sisi , Liu Hong , Yao Jialing
Published: March 2023

Understanding the molecular mechanisms of seed germination and seedling growth is vital for mining functional genes for the improvement of plant drought in a desert. Tamarix hispida is extremely resistant to drought and soil salinity perennial shrubs or trees. This study was the first to investigate the protein abundance profile of the transition process during the processes of T. hispida seed germination and seedling growth using label-free proteomics approaches. Our data suggested that asynchronous regulation of transcriptomics and proteomics occurs upon short-term seed germination and seedling growth of T. hispida. Enrichment analysis revealed that the main differentially abundant proteins had significant enrichment in stimulus response, biosynthesis, and metabolism. Two delta-1-pyrroline-5-carboxylate synthetases (P5CS), one Ycf3-interacting protein (Y3IP), one low-temperature-induced 65 kDa protein-like molecule, and four peroxidases (PRX) were involved in both water deprivation and hyperosmotic salinity responses. Through a comparative analysis of transcriptomics and proteomics, we found that proteomics may be better at studying short-term developmental processes. Our results support the existence of several mechanisms that enhance tolerance to salinity and drought stress during seedling growth in T. hispida.
Trauma-Related Clinical Practice Variation in Dutch Emergency Departments
Authors: Tierie Elise L. , Barten Dennis G. , Esteve Cuevas Laura M. , Veugelers Rebekka , Gaakeer Menno I.
Published: March 2023

Structural insights in the use of protocols and the extent of practice variation in EDs are lacking. The objective is to determine the extent of practice variation in EDs in The Netherlands, based on specified common practices. We performed a comparative study on Dutch EDs that employed emergency physicians to determine practice variation. Data on practices were collected via a questionnaire. Fifty-two EDs across The Netherlands were included. Thrombosis prophylaxis was prescribed for below-knee plaster immobilization in 27% of EDs. Vitamin C was prescribed in 50% of EDs after a wrist fracture. Splitting of applied casts to the upper or lower limb was performed in one-third of the EDs. Analysis of the cervical spine after trauma was performed by the NEXUS criteria (69%), the Canadian C-spine Rule (17%) or otherwise. The imaging modality for cervical spine trauma in adults was a CT scan (98%). The cast used for scaphoid fractures was divided between the short arm cast (46%) and the navicular cast (54%). Locoregional anaesthesia for femoral fractures was applied in 54% of the EDs. EDs in The Netherlands showed considerable practice variation in treatments among the subjects studied. Further research is warranted to gain a full understanding of the variation in practice in EDs and the potential to improve quality and efficiency.
Common Traditions, Practices, and Beliefs Related to Safe Motherhood and Newborn Health in Morocco
Authors: Moujahid Chaimae , Turman Jack E. , Amahdar Loubna
Published: March 2023

The cultural context influences women’s antenatal care and postpartum knowledge. This study aims to determine the traditional practices related to maternal health in Morocco. We conducted in-depth qualitative interviews with 37 women from three different Moroccan regions on the first postpartum day. We used thematic content to analyze data, and an a priori coding framework was created utilizing the pertinent literature. Beliefs regarding pregnancy and postpartum positively affect maternal health, such as family support, prolonged rest for health recovery, and specific dietary precautions according to the mode of delivery of the new mother. However, some practices may negatively affect maternal health, such as cold postpartum treatment through traditional medicine and not seeking prenatal care after the first pregnancy experience. Such practices include painting newborns with henna, using kohl and oil to hasten the umbilical cord’s descent, and producing solutions based on chicken throat to cure respiratory ailments in newborns that might harm their health.
Functional Disability and Symptomatic Slow-Acting Drugs for Osteoarthritis in Adults with Periodontitis
Authors: Nik-Azis Nik-Madihah , Mohd Nurulhuda , Baharin Badiah , Mohd Fadzilah Fazalina , Mohamed Haflah Nor Hazla , Mohamed Said Mohd Shahrir
Published: March 2023

Osteoarthritis (OA) patients have decreased functional ability and restricted access to healthcare facilities and are on a spectrum of medications. These can impact their oral health. This study aims to investigate the association between periodontal disease and OA disease parameters, specifically the functional disability and the medications taken. This was a cross-sectional study on OA participants recruited from the Hospital Canselor Tuanku Mukhriz. Periodontal health parameters were obtained from an oral examination of the participants. A Health Assessment Questionnaire (HAQ) was administered to ascertain the functional status of the participants. Out of the 130 participants recruited, 71 (54.6%) had periodontitis. There was a correlation between the teeth count with OA severity, where participants with a greater Kellgren–Lawrence score had less teeth (rs = 0.204, p = 0.025). Participants with a greater degree of functional limitation also had less teeth (rs = −0.181, p = 0.039) and a higher clinical attachment loss (rs = 0.239, p = 0.006). There were no associations found between the symptomatic slow-acting drugs in OA and periodontal health parameters. In conclusion, there was a high proportion of periodontitis in patients with OA. Functional disability was associated with measures of periodontal health. It is suggested that clinicians treating OA patients consider the need for a referral for dental care when managing this group of patients.
Hypoxia-Inducible Factor-Prolyl-Hydroxylase and Sodium-Glucose Cotransporter 2 Inhibitors for Low-Risk Myelodysplastic Syndrome-Related Anemia in Patients with Chronic Kidney Disease: A Report of Three Cases
Authors: Yamasaki Satoshi , Horiuchi Takahiko
Published: March 2023

Although daprodustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, and dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, have been approved for the treatment of renal anemia in Japan, their efficacy and safety for patients aged 80 years or older with low-risk myelodysplastic syndrome (MDS)-related anemia have not been demonstrated. Our case series comprised two men and one woman aged >80 years with low-risk MDS-related anemia and diabetic mellitus (DM)-related chronic kidney disease who were dependent on red blood cell transfusions and in whom erythropoiesis-stimulating agents had been insufficient. All three patients received daprodustat and additional dapagliflozin achieved red blood cell transfusion independence and were followed up for >6 months. Daily oral daprodustat was well tolerated. There were no fatalities or progression to acute myeloid leukemia during the >6-month follow-up after daprodustat initiation. On the basis of these outcomes, we consider 24 mg of daprodustat combined with 10 mg of dapagliflozin daily an effective form of treatment for low-risk MDS-related anemia. Further studies are required to clarify the synergistic effects of daprodustat and dapagliflozin, which correct chronic kidney disease-related anemia by promoting endogenous erythropoietin production and normalizing iron metabolism to manage low-risk MDS in the long term.
GIS-Facilitated Seed Germination, Fertilization Effects on Growth, Nutrient and Phenol Contents and Antioxidant Potential in Three Local Endemic Plants of Crete (Greece) with Economic Interest: Implications for Conservation and Sustainable Exploitation
Authors: Hatzilazarou Stefanos , Kostas Stefanos , Pipinis Elias , Anestis Ioannis , Papaioannou Evgenia , Aslanidou Vasiliki , Tsoulpha Parthena , Avramakis Manolis , Krigas Nikos , Tsoktouridis George
Published: March 2023

This multidisciplinary study is focused on the conservation and sustainable utilization of Lomelosia minoana (Dipsacaceae; subsp. minoana and subsp. asterusica) and Eryngium ternatum (Apiaceae), three local endemic plants of Crete (Greece) with economic interest. Using Geographical Information Systems and open-source geodatabases, detailed ecological profiles were compiled to illustrate the abiotic environmental conditions prevailing in their wild habitats. We examined for the first time temperature effects (10, 15, 20 and 25 °C) on seed germination and fertilization effects (INM, integrated nutrient management, and chemical fertilization compared to control) on growth parameters and nutrient content of leaves as well as their phenol content and antioxidant potential. L. minoana subsp. asterusica germinated better at 15 °C (61.25%), subsp. minoana at 10 and 15 °C (30% and 27.50%, respectively) while E. ternatum did not show significant differences. The seedling fertilization with INM resulted in 10–15-fold higher absorption of copper without toxicity compared with chemical fertilization and the control; INM was also superior to chemical fertilization in most of the macronutrients in leaves. The total phenol content and the antioxidant capacity of leaf extracts were positively affected by chemical fertilization in L. minoana subsp. minoana and E. ternatum. Both fertilization treatments almost equally affected the morphological and physiological characteristics of the examined taxa. In light of the above-mentioned and the research gaps bridged for the studied taxa, we re-evaluated and updated both the feasibility and the readiness timescale for their sustainable exploitation in economic sectors.
In Vitro Screening for Salinity Tolerance in Garden Pea (Pisum sativum L.)
Authors: Grozeva Stanislava , Kalapchieva Slavka , Tringovska Ivanka
Published: March 2023

Soil salinity is one of the abiotic stress factors gaining importance in recent years due to the changing climate and rising temperatures. This possesses a serious risk to food security worldwide and a range of adaptations and mitigation strategies are required. Crop improvement through breeding is a possible solution to overcome salinity stress. In this respect, a study was designed to screen a collection from garden pea accessions to salinity tolerance in in vitro conditions. We analyzed the effects of four salinity levels (0, 50, 100, and 200 mM NaCl) on seed germination, seedling emergence, shoot and root lengths, and plant fresh weight in 22 garden pea genotypes. Data showed that more of the pea genotypes are able to tolerate 50 mM NaCl concentration. The increasing of salt levels to 100 and 200 mM NaCl caused a significant decrease in germination and reduced the length and weight of shoots and roots. Among the genotypes, varieties Uspeh 72, Paldin, and Flora 6 were highly sensitive to salinity stress, while varieties Prometey, Musala, and Zornitsa were distinguished as more tolerant. The results depicted that salinity treatments had a more negative effect on plant growth than on seed germination, which is probably due to the in vitro conditions in which the experiments were conducted. The studied accessions of garden pea were sensitive to salt stress; nevertheless, some tolerant accessions were identified.
Nitrogen Interactions Cause Soil Degradation in Greenhouses: Their Relationship to Soil Preservation in China
Authors: Awadelkareem Waleed , Haroun Mohammed , Wang Juanjuan , Qian Xiaoqing
Published: March 2023

Proper greenhouse fertilization is crucial for establishing high-quality yields, particularly as food demand grows. In this review, the effect of fertilizers, specifically nitrogen, on greenhouses and degradation caused by nitrogen interactions are critically evaluated based on a literature analysis. Nitrogen (N) fertilizers, which represent reactive or biologically accessible nitrogen in soil, are currently used in agricultural systems. Soil, water, and air are endangered by reactive nitrogen pollution. Increasing food demand causes a rise in N fertilizer use, which harms the environment and living organisms. In developing countries, more N is used per capita than in underdeveloped countries. Greenhouse agriculture accounts for 3.6% of total agricultural production. It was revealed that greenhouses in China often get 13–17 times as much nitrogen fertilizer as traditional farming. N was overused abundantly throughout the year, which led to soil acidity, nutritional imbalance, and secondary salinization. Studies on soil salinization and secondary salinization in China date back 70 years. This review attempts to draw attention to the soil damage in greenhouses caused by excessive nitrogen. Nitrate leaching and soil acidity received special attention in this review. Numerous eco-friendly techniques for avoiding soil degradation brought on by the execessive use of fertilizer are also discussed.
Odonata as Indicators? Dragonflies and Damselflies Respond to Riparian Conditions along Ozark Spring Streams
Authors: Cheri Cameron R. , Finn Debra S.
Published: March 2023

The Odonata are not typically regarded as informative taxa for stream bioassessment in North America compared to other insects, particularly when monitoring the ecological impacts of organic pollution. However, we hypothesized that stream-dwelling odonates are useful bioindicators of riparian conditions because vegetation associated with streams is used for oviposition and establishing breeding territories and is likely a cue for a suitable nymphal habitat. We sampled odonates from multiple microhabitats and all macroinvertebrates from riffle habitat in 12 Ozark Highlands (USA) spring streams along a gradient of riparian conditions. We also measured a standard suite of physical and chemical variables in each stream. We compared various aspects of the odonate and riffle macroinvertebrate assemblages among sites to evaluate sensitivity to variables associated with riparian structure compared to the other physical and chemical variables measured. The odonates were strongly associated with riparian-specific variables, while riffle macroinvertebrates were associated with riparian variables to a lesser degree. The additional environmental variables explained minimal variation in either assemblage. Overall, our results suggest that Odonata alone could be useful for biomonitoring associated with riparian structure around Ozark spring streams. The sensitivity of odonates to riparian conditions in other Nearctic regions should be further studied to identify regional and species-specific differences.
Participation in the Global Corporate Challenge®, a Four-Month Workplace Pedometer Program, Reduces Psychological Distress
Authors: Stone Jessica , Barker S. Fiona , Gasevic Danijela , Freak-Poli Rosanne
Published: March 2023

Background: Psychological distress (stress) has been linked to an increased risk of chronic diseases and is exacerbated by a range of workplace factors. Physical activity has been shown to alleviate psychological distress. Previous pedometer-based intervention evaluations have tended to focus on physical health outcomes. This study aimed to investigate the immediate and long-term changes in psychological distress in employees based in Melbourne, Australia after their participation in a four-month pedometer-based program in sedentary workplaces. Methods: At baseline, 716 adults (aged 40 ± 10 years, 40% male) employed in primarily sedentary occupations, voluntarily enrolled in the Global Corporate Challenge© (GCC©), recruited from 10 Australian workplaces to participate in the GCC® Evaluation Study, completed the Kessler 10 Psychological Distress Scale (K10). Of these, 422 completed the K10 at baseline, 4 months and 12 months. Results: Psychological distress reduced after participation in a four-month workplace pedometer-based program, which was sustained eight months after the program ended. Participants achieving the program goal of 10,000 steps per day or with higher baseline psychological distress had the greatest immediate and sustained reductions in psychological distress. Demographic predictors of immediate reduced psychological distress (n = 489) was having an associate professional occupation, younger age, and being ‘widowed, separated or divorced’. Conclusions: Participation in a workplace pedometer-based program is associated with a sustained reduction in psychological distress. Low-impact physical health programs conducted in groups or teams that integrate a social component may be an avenue to improve both physical and psychological health in the workplace.
Exploratory Study on Central Sensitization and Bioelectrical Activity of the Selected Masticatory Muscles in Subjects with Myopia
Authors: Zieliński Grzegorz , Matysik-Woźniak Anna , Baszczowski Michał , Rapa Maria , Ginszt Michał , Szkutnik Jacek , Rejdak Robert , Gawda Piotr
Published: March 2023

Background: Myopia is one of the most common eye disorders involving abnormal focusing of light rays. The studies recognize the association between the stomatognathic and visual systems. This compound may have a neurological basis associated with disorders such as central sensitization. The main aim of this study was to evaluate the influence of central sensitization on the bioelectrical activity of selected muscles of the masticatory organ in subjects with myopia. Methods: Selected masticatory and cervical spine muscles were analyzed using an eight-channel BioEMG III electromyograph. Central sensitization was analyzed using the central sensitization inventory. Results: Statistical analysis revealed significantly higher scores on the central sensitization inventory in subjects with axial myopia compared to subjects without refractive error. Repeated positive correlations were observed in the sternocleidomastoid muscle activity and negative correlations in the digastric muscle activity during open and closed eyes in myopic subjects. Conclusions: Subjects with myopia have an increased score in the central sensitization inventory. The increase in the central sensitization inventory score is connected with the changes within the electromyographic activity of the masticatory and neck muscles. The effect of central sensitization on masticatory muscle activity in myopic subjects requires further study.
Study on the Radioactivity Levels of Metal Tailings in the Lhasa Area of Tibet
Authors: Weng Rengui , Tian Feng , Chen Guohong , Dong Shuo , Bai Junjiang
Published: March 2023

The main purpose of this study was to determine the natural radioactivity level of raw radionuclides in the metal tailings of a mine in Lhasa, Tibet, and to conduct sampling and detection in 17 typical metal tailing mines in Lhasa, Tibet. The specific activity concentrations of 226Ra, 232Th, and 40K in the samples were calculated. The total αβχγ radiation, radon concentration, and outdoor absorbed dose rate in the air 1.0 m above the ground were measured. The γ radiation levels affecting miners and their surrounding residents were assessed. The results show that the radiation dose ranges from 0.08 μSv/h to 0.26 μSv/h, and the radon concentration ranges from 10.8 Bq/m3 to 29.6 Bq/m3, which does not exceed the national radiation-related standards, and the environmental hazard risk is low. The specific activity concentration of 226Ra ranged from 8.91 Bq/kg to 94.61 Bq/kg, the specific activity concentration of 232Th ranged from 2.90 Bq/kg to 89.62 Bq/kg, and the specific activity concentration of 40K was less than MDA to 762.89 Bq/kg. The average absorbed dose rate (DO) of the 17 mining areas was 39.82 nGy/h, the average annual effective dose rate (EO) was 0.057 mSv/y. The average external risk index of the 17 mining areas was 0.24, the average internal risk index was 0.34, and the average γ index was 0.31, all of which were less than the maximum permissible limit. This means that the metal tailings from all 17 mining areas were within the limit for γ radiation and, therefore, can be used in bulk as major building materials without posing a significant radiation threat to the residents of the study area.
Solvent Extraction for Separation of Indonesian Oil Sands
Authors: Cui Wenlong , Zhu Qingqing , Zhao Chenze , Zhou Weiyou , Wang Cheli
Published: March 2023

Based on the examination of the basic properties, the solvent extraction process (SEP) was applied with high efficiency in the extraction of bitumen from Indonesian oil sands. To separate the oil sands, different organic solvents were first screened, and the extraction effects were analyzed to select a suitable solvent. Then, the effects of operating conditions on the extraction rate of bitumen were investigated. Finally, the compositions and structures of the bitumen obtained under suitable conditions were analyzed. The results showed that the Indonesian oil sands were oil-wet oil sands with a bitumen content of 24.93%, containing a large number of asphaltenes and resins with high polarity and complex structures. The separation performance was affected by different organic solvents and operating conditions. It was shown that the closer the structure and polarity of the selected solvent is to the solute, the better the extraction effect. The extraction rate of bitumen reached 18.55% when toluene was used as the extraction solvent under the operating conditions of V (solvent):m (oil sands) 3:1, temperature 40 °C, stirring velocity 300 r/min, time 30 min. The method could also be applied to the separation of other oil-wet oil sands. The compositions and structures of bitumen can guide the separation and comprehensive use of industrial oil sands.
Corporate Sustainability Development Strategy and Corporate Environmental Governance—The Moderating Role of Corporate Environmental Investments
Authors: Ao Xiangyuan , Ong Tze San , Teh Boon Heng
Published: March 2023

Environmental degradation and ecological devastation have become widespread global concerns in recent years as a result of the expansion of the international economy. China’s rapid economic development has been accompanied by a sloppy economic growth model that has damaged the local ecological environment. The Chinese government intends to improve the ecological environment by the end of 2020 in an effort to direct and improve these environmental issues. The strictest environmental laws became effective in 2015. In light of this, this research uses panel data analysis to examine the environmental strategy and environmental governance of Chinese corporations. This article analyses 14,512 samples of listed mainland Chinese enterprises from 2015 to 2020. This research investigates the connection between Corporate Sustainability Development Strategy and Corporate Environmental Governance, as well as the moderating effect of Corporate Environmental Investments.
Knowledge, Awareness, and Attitude of Healthcare Stakeholders on Alzheimer’s Disease and Dementia in Qatar
Authors: Paul Pradipta , Mahfoud Ziyad Riyad , Malik Rayaz A. , Kaul Ridhima , Muffuh Navti Phyllis , Al-Sheikhly Deema , Chaari Ali
Published: March 2023

Dementia is characterized by progressive cognitive decline, memory impairment, and disability. Alzheimer’s disease (AD) accounts for 60–70% of cases, followed by vascular and mixed dementia. Qatar and the Middle East are at increased risk owing to aging populations and high prevalence of vascular risk factors. Appropriate levels of knowledge, attitudes, and awareness amongst health care professionals (HCPs) are the need of the hour, but literature indicates that these proficiencies may be inadequate, outdated, or markedly heterogenous. In addition to a review of published quantitative surveys investigating similar questions in the Middle East, a pilot cross-sectional online needs-assessment survey was undertaken to gauge these parameters of dementia and AD among healthcare stakeholders in Qatar between 19 April and 16 May 2022. Overall, 229 responses were recorded between physicians (21%), nurses (21%), and medical students (25%), with two-thirds from Qatar. Over half the respondents reported that >10% of their patients were elderly (>60 years). Over 25% reported having contact with >50 patients with dementia or neurodegenerative disease annually. Over 70% had not undertake related education/training in the last 2 years. The knowledge of HCPs regarding dementia and AD was moderate (mean score of 5.3 ± 1.5 out of 7) and their awareness of recent advances in basic disease pathophysiology was lacking. Differences existed across professions and location of respondents. Our findings lay the groundwork for a call-to-action for healthcare institutions to improve dementia care within Qatar and the Middle East region.
Spatial Distribution Characteristics and Influencing Factors of Rural Governance Demonstration Villages in China
Authors: Xie Xinyu , Zhang Ying , Qiu Xiaoping
Published: March 2023

Rural governance plays a significant role in constructing national governance systems and promoting rural development. An accurate understanding of the spatial distribution characteristics and influencing factors of rural governance demonstration villages is conducive to giving full play to their leading, demonstration and radiating roles and further promoting the modernization of rural governance systems and governance capacity. Therefore, this study uses Moran’s I analysis, local correlation analysis, kernel density analysis and a geographic concentration index to analyze the spatial distribution characteristics of rural governance demonstration villages. Moreover, this study proposes a conceptual framework to construct the cognition of rural governance and uses Geodetector and vector data buffer analysis methods to explore the internal influence mechanism of their spatial distribution. The results show the following: (1) The spatial distribution of rural governance demonstration villages in China is unbalanced. The distribution difference between the two sides of the “Hu line” is significant. The peak appears at 30° N and 118° E. (2) The rural governance demonstration villages in China are clustered, which forms a high-density core area, a sub-high density belt, two sub-high-density centers and several single core concentration areas. Additionally, the hot spots of rural governance demonstration villages in China are mostly located on the eastern coast, tending to cluster in places with superior natural conditions, convenient transportation, and excellent economic development. (3) Based on the distribution characteristics of Chinese rural governance demonstration villages, this study proposes a “one core, three axes and multiple centers” spatial structure to optimize the distribution of rural governance demonstration villages. (4) A rural governance framework system consists of a governance subject subsystem and influencing factor subsystem. The results of Geodetector show that under the mutual leading role of the three governance subjects, the distribution of rural governance demonstration villages in China is the result of multiple factors. Among them, nature is the basic factor, economy is the key factor, politics is the dominant factor, and demographic is the important factor. The interaction network formed by general public budget expenditure and total power of agricultural machinery affects the spatial distribution pattern of the rural governance demonstration villages in China.
A New Interpretation of Relative Importance on an Analysis of Per and Polyfluorinated Alkyl Substances (PFAS) Exposures on Bone Mineral Density
Authors: Kirk Andrea B. , DeStefano Alisa , Martin Alexander , Kirk Karli C. , Martin Clyde F.
Published: March 2023

Background: The relative contribution of environmental contaminants is an important, and frequently unanswered, question in human or ecological risk assessments. This interpretation of relative importance allows determination of the overall effect of a set of variables relative to other variables on an adverse health outcome. There are no underlying assumptions of independence of variables. The tool developed and used here is specifically designed for studying the effects of mixtures of chemicals on a particular function of the human body. Methods: We apply the approach to estimate the contributions of total exposure to six PFAS (perfluorodecanoic acid, perfluorohexane sulfonic acid, 2-(N-methyl-PFOSA) acetate, perfluorononanoic acid, perfluoroundecanoic acid and perfluoroundecanoic acid) to loss of bone mineral density relative to other factors related to risk of osteoporosis and bone fracture, using data from subjects who participated in the US National Health Examination and Nutrition Surveys (NHANES) of 2013–2014. Results: PFAS exposures contribute to bone mineral density changes relative to the following variables: age, weight, height, vitamin D2 and D3, gender, race, sex hormone binding globulin, testosterone, and estradiol. Conclusion: We note significant alterations to bone mineral density among more highly exposed adults and significant differences in effects between men and women.
A Qualitative Study of Rural and Remote Australian General Practitioners’ Involvement in High-Acuity Patients
Authors: Turner Sinead , Isaac Vivian , Lim David
Published: March 2023

This study aimed to understand the experiences, barriers, and facilitators of rural general practitioners’ involvement with high-acuity patients. Semi-structured interviews with rural general practitioners in South Australia who had experience delivering high-acuity care were audio-recorded, transcribed verbatim, and analyzed through content and thematic approaches incorporating Potter and Brough’s capacity-building framework. Eighteen interviews were conducted. Barriers identified include the inability to avoid high-acuity work in rural and remote areas, pressure to handle complex presentations, lack of appropriate resources, lack of mental health support for clinicians, and impacts on social life. Enablers included a commitment to community, comradery in rural medicine, training, and experience. We concluded that general practitioners are a vital pillar of rural health service delivery and are inevitably involved in disaster and emergency response. While the involvement of rural general practitioners with high-acuity patients is complex, this study suggested that with the appropriate system, structure and role supports, rural general practitioners could be better empowered to manage high-acuity caseloads locally.
Research on the Evaluation and Spatial Characteristics of China’s Provincial Socioeconomic Development and Pollution Control Based on the Lotka–Volterra Model
Authors: Zhou Xue , Wang Jiapeng
Published: March 2023

Aims: To evaluate the degree of mutualism between socioeconomic development and industrial and domestic pollution in provinces of China and to analyze the differences in spatial characteristics between their regions. Methods: This study used the HDI to measure socioeconomic development and the Lotka–Volterra model to group and estimate the force-on and mutualism degree indexes of industrial and domestic pollution and socioeconomic development in 31 provinces of China, which were then used to them. Then, the study calculated the global and local Moran’s I under different space weights matrices to analyze their spatial autocorrelation and heterogeneity. Results: The research showed that in 2016–2020, compared with 2011–2015, the number of provinces where socioeconomic development and industrial pollution control mutually promoted each other was approximately the same, while the number of provinces that promoted each other’s effectiveness with domestic pollution control was reduced. There were many provinces with industrial pollution ranked in the S-level, while most provinces placed a different emphasis on industrial and domestic pollution control. The rank in China tended to be spatially balanced in 2016–2020. There was a negative spatial autocorrelation between the ranks of most provinces and neighboring provinces in 2011–2020. The ranks of some eastern provinces showed a phenomenon of a high–high agglomeration, while the ranks of provinces in the western region were dominated by a high–low agglomeration.
Development of an Online Mind–Body Physical Activity Intervention for Young Adults during COVID-19: A Pilot Study
Authors: Strehli Ildiko , Burns Ryan D. , Bai Yang , Ziegenfuss Donna H. , Block Martin E. , Brusseau Timothy A.
Published: March 2023

The purpose of this study was to examine the association between the implementation of an online mind–body physical activity (MBPA) intervention and physical activity (PA), stress, and well-being in young adults during COVID-19. The participants were a sample of college students (N = 21; 81% female). The MBPA intervention was organized in four online modules that were administered asynchronously for 8 weeks with three separate 10 min sessions per week. The intervention components consisted of traditional deep breathing, diaphragm mindful breathing, yoga poses, and walking meditation. Objective PA behaviors were assessed using wrist-worn ActiGraph accelerometers, and stress and well-being data were collected using validated self-report instruments. A 2 (sex) × 3 (time) doubly multivariate analysis of variance test with a univariate follow-up showed that the % of wear time in light (LPA) and moderate-to-vigorous physical activity (MVPA) was significantly higher at the end of the intervention compared to baseline (LPA mean difference = 11.3%, p = 0.003, d = 0.70; MVPA mean difference = 2.9%, p < 0.001, d = 0.56). No significant differences were observed for perceived stress and well-being, and there was no moderating effect of sex. The MBPA intervention showed promise, as it was associated with higher PA in young adults during COVID-19. No improvements were observed for stress and well-being. These results warrant further testing of the intervention’s effectiveness using larger samples.