bluuebunny/crossref_metadata_2025 huggingface dataset:
The Placentas of Women Who Suffer an Episode of Psychosis during Pregnancy Have Increased Lipid Peroxidation with Evidence of Ferroptosis
Authors: Ortega Miguel A. , Fraile-Martinez Oscar , García-Montero Cielo , Funes Moñux Rosa M. , Rodriguez-Martín Sonia , Bravo Coral , De Leon-Luis Juan A. , Saz Jose V. , Saez Miguel A. , Guijarro Luis G. , Lahera Guillermo , Mora Fernando , Fernandez-Rojo Sonia , Quintero Javier , Monserrat Jorge , García-Honduvilla Natalio , Bujan Julia , Alvarez-Mon Melchor , Alvarez-Mon Miguel Angel
Published: January 2023

Psychosis is a complex entity characterized by psychological, behavioral, and motor alterations resulting in a loss of contact with reality. Although it is not common, pregnancy can be a period in which a first episode of psychosis can manifest, entailing detrimental consequences for both the fetus and the mother. The pathophysiological basis and study of maternofetal wellbeing need to be further elucidated. Lipid peroxidation and ferroptosis are two phenomena that are tightly linked to the placental dysfunction commonly observed in different complications of pregnancy. In the present study, we aim to explore the histopathological and gene expression of different markers of lipid peroxidation and ferroptosis in the placentas of women who underwent a first episode of psychosis during their pregnancy (n = 22). The aim is to then compare them with healthy pregnant women (n = 20). In order to achieve this goal, iron deposits were studied using Prussian Blue staining. In addition, the protein/gene expression of a transferrin receptor (TFRC), as well as an acyl-CoA synthetase long-chain family member 4 (ACSL-4), arachidonate lipoxygenase-5 (ALOX-5), malondialdehyde (MDA), and glutathione peroxidase 4 (GPX4) were all analyzed through gene expression (RT-qPCR) and immunohistochemical procedures. Our results demonstrate an increased presence of iron deposits that are accompanied by a further expression of TFRC, ACSL-4, ALOX-5, MDA, and GPX4—all of which are observed in the placenta tissue of women who have suffered from a first episode of psychosis. Therefore, in our study, a histopathological increase in lipid peroxidation and ferroptosis markers in the affected women is suggested. However, further studies are needed in order to validate our results and to establish possible consequences for the reported alterations.
Illuminating Intrinsically Disordered Proteins with Integrative Structural Biology
Authors: Evans Rachel , Ramisetty Sravani , Kulkarni Prakash , Weninger Keith
Published: January 2023

Intense study of intrinsically disordered proteins (IDPs) did not begin in earnest until the late 1990s when a few groups, working independently, convinced the community that these ‘weird’ proteins could have important functions. Over the past two decades, it has become clear that IDPs play critical roles in a multitude of biological phenomena with prominent examples including coordination in signaling hubs, enabling gene regulation, and regulating ion channels, just to name a few. One contributing factor that delayed appreciation of IDP functional significance is the experimental difficulty in characterizing their dynamic conformations. The combined application of multiple methods, termed integrative structural biology, has emerged as an essential approach to understanding IDP phenomena. Here, we review some of the recent applications of the integrative structural biology philosophy to study IDPs.
Hybridized Deep Learning Approach for Detecting Alzheimer’s Disease
Authors: Balaji Prasanalakshmi , Chaurasia Mousmi Ajay , Bilfaqih Syeda Meraj , Muniasamy Anandhavalli , Alsid Linda Elzubir Gasm
Published: January 2023

Alzheimer’s disease (AD) is mainly a neurodegenerative sickness. The primary characteristics are neuronal atrophy, amyloid deposition, and cognitive, behavioral, and psychiatric disorders. Numerous machine learning (ML) algorithms have been investigated and applied to AD identification over the past decades, emphasizing the subtle prodromal stage of mild cognitive impairment (MCI) to assess critical features that distinguish the disease’s early manifestation and instruction for early detection and treatment. Identifying early MCI (EMCI) remains challenging due to the difficulty in distinguishing patients with cognitive normality from those with MCI. As a result, most classification algorithms for these two groups perform poorly. This paper proposes a hybrid Deep Learning Approach for the early detection of Alzheimer’s disease. A method for early AD detection using multimodal imaging and Convolutional Neural Network with the Long Short-term memory algorithm combines magnetic resonance imaging (MRI), positron emission tomography (PET), and standard neuropsychological test scores. The proposed methodology updates the learning weights, and Adam’s optimization is used to increase accuracy. The system has an unparalleled accuracy of 98.5% in classifying cognitively normal controls from EMCI. These results imply that deep neural networks may be trained to automatically discover imaging biomarkers indicative of AD and use them to identify the illness accurately.
SERPINA3: Stimulator or Inhibitor of Pathological Changes
Authors: de Mezer Mateusz , Rogaliński Jan , Przewoźny Stanisław , Chojnicki Michał , Niepolski Leszek , Sobieska Magdalena , Przystańska Agnieszka
Published: January 2023

SERPINA3, also called α-1-antichymotrypsin (AACT, ACT), is one of the inhibitors of serine proteases, one of which is cathepsin G. As an acute-phase protein secreted into the plasma by liver cells, it plays an important role in the anti-inflammatory response and antiviral response. Elevated levels of SERPINA3 have been observed in heart failure and neurological diseases such as Alzheimer’s disease or Creutzfeldt–Jakob disease. Many studies have shown increased expression levels of the SERPINA3 gene in various types of cancer, such as glioblastoma, colorectal cancer, endometrial cancer, breast cancer, or melanoma. In this case, the SERPINA3 protein is associated with an antiapoptotic function implemented by adjusting the PI3K/AKT or MAPK/ERK 1/2 signal pathways. However, the functions of the SERPINA3 protein are still only partially understood, mainly in the context of cancerogenesis, so it seems necessary to summarize the available information and describe its mechanism of action. In particular, we sought to amass the existing body of research focusing on the description of the underlying mechanisms of various diseases not related to cancer. Our goal was to present an overview of the correct function of SERPINA3 as part of the defense system, which unfortunately easily becomes the “Fifth Column” and begins to support processes of destruction.
Pancreatic Cancer Resistance to Treatment: The Role of Microbiota
Authors: Nista Enrico Celestino , Del Gaudio Angelo , Del Vecchio Livio Enrico , Mezza Teresa , Pignataro Giulia , Piccioni Andrea , Gasbarrini Antonio , Franceschi Francesco , Candelli Marcello
Published: January 2023

Pancreatic cancer (PC) is an aggressive malignancy and the fourth leading cause of cancer death in the United States and Europe. It is estimated that PC will be the second leading cause of cancer death by 2030. In addition to late diagnosis, treatment resistance is a major cause of shortened survival in pancreatic cancer. In this context, there is growing evidence that microbes play a regulatory role, particularly in therapy resistance and in creating a microenvironment in the tumor, that favors cancer progression. The presence of certain bacteria belonging to the gamma-proteobacteria or mycoplasmas appears to be associated with both pharmacokinetic and pharmacodynamic changes. Recent evidence suggests that the microbiota may also play a role in resistance mechanisms to immunotherapy and radiotherapy. However, the interactions between microbiota and therapy are bilateral and modulate therapy tolerance. Future perspectives are increasingly focused on elucidating the role of the microbiota in tumorigenesis and processes of therapy resistance, and a better understanding of these mechanisms may provide important opportunities to improve survival in these patients.
A Longitudinal Observational Study of Medical Cannabis Use and Polypharmacy among Patients Presenting to Dispensaries in Pennsylvania
Authors: Hajjar Emily R. , Herens Allison , Kelly Erin L. , Madden Kayla , Lungen Jessica M. , Worster Brooke K.
Published: January 2023

Background: Cannabis use is increasing among adults to treat a variety of health conditions. Given the potential for interactions and adverse events, it is important to assess the use of medical cannabis along with other concomitant medications when assessing for polypharmacy. Methods: The objective of this observational, longitudinal study was to examine medical cannabis (MC) use along with concomitant medications over 12 months in patients with serious medical conditions enrolled in the Pennsylvania (PA) Department of Health’s (DOH) Medical Marijuana Program and to collect and catalog which forms of MC patients are taking along with their concomitant medications. Results: There were 213 participants who completed the baseline surveys in full, and 201, 187, and 175 who completed the 1, 6, and 12-month follow-up surveys. The mean age of the participants was 41.3 years, and 54.5% were female. The mean number of MC products taken at baseline was 3.41 and 3.47 at the 12-month survey. Participants took an average of 3.76 (SD 3.15) medications at baseline and 3.65 (SD 3.4) at 12 months. Most commonly used concomitant medications at baseline included vitamins (42.3%), antidepressants (29.1%), analgesics (22.1%), herbal products (19.7%), and anxiolytics (17.8%). Conclusion: Participants used multiple medical cannabis products to treat a number of medication conditions in conjunction with multiple medications.
Immuno-Modulatory Effects of Dexamethasone in Severe COVID-19—A Swedish Cohort Study
Authors: Asif Sana , Frithiof Robert , Larsson Anders , Franzén Stephanie , Anderberg Sara Bülow , Kristensen Bjarne , Hultström Michael , Lipcsey Miklos
Published: January 2023

Dexamethasone (Dex) has been shown to decrease mortality in severe coronavirus disease 2019 (COVID-19), but the mechanism is not fully elucidated. We aimed to investigate the physiological and immunological effects associated with Dex administration in patients admitted to intensive care with severe COVID-19. A total of 216 adult COVID-19 patients were included—102 (47%) received Dex, 6 mg/day for 10 days, and 114 (53%) did not. Standard laboratory parameters, plasma expression of cytokines, endothelial markers, immunoglobulin (Ig) IgA, IgM, and IgG against SARS-CoV-2 were analyzed post-admission to intensive care. Patients treated with Dex had higher blood glucose but lower blood lactate, plasma cortisol, IgA, IgM, IgG, D-dimer, cytokines, syndecan-1, and E-selectin and received less organ support than those who did not receive Dex (Without-Dex). There was an association between Dex treatment and IL-17A, macrophage inflammatory protein 1 alpha, syndecan-1 as well as E-selectin in predicting 30-day mortality. Among a subgroup of patients who received Dex early, within 14 days of COVID-19 debut, the adjusted mortality risk was 0.4 (95% CI 0.2–0.8), i.e., 40% compared with Without-Dex. Dex administration in a cohort of critically ill COVID-19 patients resulted in altered immunological and physiologic responses, some of which were associated with mortality.
Ultrasound Elastography: Basic Principles and Examples of Clinical Applications with Artificial Intelligence—A Review
Authors: Cè Maurizio , D'Amico Natascha Claudia , Danesini Giulia Maria , Foschini Chiara , Oliva Giancarlo , Martinenghi Carlo , Cellina Michaela
Published: January 2023

Ultrasound elastography (USE) or elastosonography is an ultrasound-based, non-invasive imaging method for assessing tissue elasticity. The different types of elastosonography are distinguished according to the mechanisms used for estimating tissue elasticity and the type of information they provide. In strain imaging, mechanical stress is applied to the tissue, and the resulting differential strain between different tissues is used to provide a qualitative assessment of elasticity. In shear wave imaging, tissue elasticity is inferred through quantitative parameters, such as shear wave velocity or longitudinal elastic modulus. Shear waves can be produced using a vibrating mechanical device, as in transient elastography (TE), or an acoustic impulse, which can be highly focused, as in point-shear wave elastography (p-SWE), or directed to multiple zones in a two-dimensional area, as in 2D-SWE. A general understanding of the basic principles behind each technique is important for clinicians to improve data acquisition and interpretation. Major clinical applications include chronic liver disease, breast lesions, thyroid nodules, lymph node malignancies, and inflammatory bowel disease. The integration of artificial intelligence tools could potentially overcome some of the main limitations of elastosonography, such as operator dependence and low specificity, allowing for its effective integration into clinical workflow.
Investigation of the Wetting Properties of Thalassemia Patients’ Blood Samples on Grade 5 Titanium Implant Surfaces: A Pilot Study
Authors: Temelci Ali , Yılmaz Hasan Güney , Ünsal Gürkan , Uyanik Lokman Onur , Yazman Dilek , Ayali Aysa , Minervini Giuseppe
Published: January 2023

Background and Objectives: Beta-thalassemia (BT) has a high prevalence in Mediterranean, Southeast Asian, and African countries. Studies stated that thalassemia is an endemic disease that causes significant health problems in Cyprus. This study aimed to measure the contact angle between the implant and blood samples from BT major patients and healthy individuals to compare the contact angles and wettability of Grade 5 titanium implant surfaces. Materials and Methods: Grade 5 titanium discs that were 10 mm in diameter were used since they mimic the surface of dental implants. Following receiving informed consent, blood samples were taken from the patients’ index fingers in each group with lancet needles and a photo of the contact angle between the blood samples and the titanium surface was taken; the collected blood was transferred to a titanium disc with a medical pipette. ImageJ software with a specific contact angle plugin was used for the contact angle measurements. Results: Theta-mean, theta-circular, and theta-ellipse values were compared between all groups, and no significant difference was found (p > 0.05). Conclusions: In this study, it was hypothesized that the patients’ rheological property of decreased deformability would affect the wettability of implant surfaces in vitro; however, no such finding was reached in this study. Since in-depth studies associated with dental implant success in BTM patients are absent in the literature and Cyprus is one of the Mediterranean countries with a high prevalence of BTM, this study was conducted to enrich the literature. While some systemic diseases may affect the contact angle between the implant surface and blood, it can be concluded that this condition was not present for BTM patients in our study. Last but not least, we emphasize that this experiment was done on a single surface type and the results can be totally different when using other surface types.
Evaluation of the Information Content for Determining the Vascular Tone Type of the Lower Extremities in Varicose Veins: A Case Study
Authors: Hammoud Ahmad , Tikhomirov Alexey , Briko Andrey , Volkov Alexander , Karapetyan Aida , Shchukin Sergey
Published: January 2023

The incidence of cardiovascular diseases is continuously increasing around the world. Therefore, the study of new methods for diagnosing cardiovascular diseases is very important. Early diagnosis and evaluation of the effectiveness of treatments are among the most important tasks. In this work, we study changes in vascular compliance and vascular tone of the lower extremities in a patient diagnosed with an early stage of varicose veins. The study is based on recording the bioimpedance signals of the lower extremities and their parts using the Rheo-32 multichannel device. Registration in the monitoring system takes place in two stages: the first in a state of relaxation, and the second after applying a local massage on one of the legs for five minutes. The results indicate a change in the type of vascular tone of the lower extremities after the massage, while the type of vascular tone changes and shifts on average towards the normotonic type. The method proposed in this study makes it possible to quantitatively and qualitatively assess changes in the tone of the vessels of the extremities.
Tunable Magneto-Plasmonic Nanosensor for Sensitive Detection of Foodborne Pathogens
Authors: Banerjee Tuhina , Panchal Nilamben , Sutton Carissa , Elliott Rebekah , Patel Truptiben , Kajal Kajal , Arogunyo Eniola , Koti Neelima , Santra Santimukul
Published: January 2023

Frequent outbreaks of food-borne pathogens, particularly E. coli O157:H7, continue to impact human health and the agricultural economy tremendously. The required cell count for this pathogenic strain of E. coli O157:H7 is relatively low and hence it is vital to detect at low colony forming unit (CFU) counts. Available detection methods, though sensitive, fall short in terms of timeliness and often require extensive sample processing. To overcome these limitations, we propose a novel magneto-plasmonic nanosensor (MPnS) by integrating surface plasmon resonance (SPR) properties with spin–spin magnetic relaxation (T2 MR) technology. We engineered MPnS by encapsulating several gold nanoparticles (GNPs) within the polymer-coating of iron oxide nanoparticles (IONPs). First, the polyacrylic acid (PAA)-coated IONPs were synthesized using a solvent precipitation method, then gold chloride solution was used to synthesize GNPs and encapsulate them within the PAA-coatings of IONPs in one step. A magnetic separation technique was used to purify the MPnS and the presence of GNPs within IONPs was characterized using transmission electron microscopy (TEM), energy dispersive x-ray spectroscopy (EDS), and other spectroscopic methods. The synthesized MPnS exhibits MR relaxation properties while possessing amplified optical properties than conventional GNPs. This allows for rapid and ultrasensitive detection of E. coli O157:H7 by SPR, T2 MR, and colorimetric readout. Experiments conducted in simple buffer and in milk as a complex media demonstrated that our MPnS-based assay could detect as low as 10 CFUs of this pathogenic strain of E. coli O157:H7 in minutes with no cross-reactivity. Overall, the formulated MPnS is robust and holds great potential for the ultrasensitive detection of E. coli O157:H7 in a simple and timely fashion. Moreover, this platform is highly customizable and can be used for the detection of other foodborne pathogens.
Sacrifice of Involved Nerve Root during Surgical Resection of Foraminal and/or Dumbbell Spinal Neurinomas
Authors: Vandenbulcke Alberto , D’Onofrio Ginevra Federica , Capo Gabriele , Baassiri Wassim , Barrey Cédric Y.
Published: January 2023

Even if usually needed to achieve the gross total resection (GTR) of spinal benign nerve sheath tumors (NSTs), nerve root sacrifice remains controversial regarding the risk of neurological deficit. For foraminal NSTs, we hypothesize that the involved root is poorly functional and thus can be safely sacrificed. All spinal benign NSTs with foraminal extension that underwent surgery from 2013 to 2021 were reviewed. The impacts of preoperative clinical status and patient and tumor characteristics on long-term outcomes were analyzed. Twenty-six patients were included, with a mean follow-up (FU) of 22.4 months. Functional motor roots (C5-T1, L3-S1) were involved in 14 cases. The involved nerve root was routinely sacrificed during surgery and GTR was obtained in 84.6% of cases. In the functional root subgroup, for patients with a pre-existing deficit (n = 5/14), neurological aggravation persisted in one case at last FU (n = 1/5), whereas for those with no preop deficit (n = 9/14), a postoperative deficit persisted in one patient only (n = 1/9). Preoperative radicular pain was the only characteristic significantly associated with an immediate postoperative motor deficit (p = 0.03). The sacrifice of an involved nerve root in foraminal NSTs seems to represent a reasonable and relevant option to resect these tumors, permitting one to achieve tumor resection in an oncologic fashion with a high rate of GTR.
The Role of the Left Inferior Frontal Gyrus in Introspection during Verbal Communication
Authors: Yoshioka Ayumi , Tanabe Hiroki C. , Nakagawa Eri , Sumiya Motofumi , Koike Takahiko , Sadato Norihiro
Published: January 2023

Conversation enables the sharing of our subjective experiences through verbalizing introspected thoughts and feelings. The mentalizing network represents introspection, and successful conversation is characterized by alignment through imitation mediated by the mirror neuron system (MNS). Therefore, we hypothesized that the interaction between the mentalizing network and MNS mediates the conversational exchange of introspection. To test this, we performed hyperscanning functional magnetic resonance imaging during structured real-time conversations between 19 pairs of healthy participants. The participants first evaluated their preference for and familiarity with a presented object and then disclosed it. The control was the object feature identification task. When contrasted with the control, the preference/familiarity evaluation phase activated the dorso-medial prefrontal cortex, anterior cingulate cortex, precuneus, left hippocampus, right cerebellum, and orbital portion of the left inferior frontal gyrus (IFG), which represents introspection. The left IFG was activated when the two participants’ statements of introspection were mismatched during the disclosure. Disclosing introspection enhanced the functional connectivity of the left IFG with the bilateral superior temporal gyrus and primary motor cortex, representing the auditory MNS. Thus, the mentalizing system and MNS are hierarchically linked in the left IFG during a conversation, allowing for the sharing of introspection of the self and others.
Speech and Nonspeech Parameters in the Clinical Assessment of Dysarthria: A Dimensional Analysis
Authors: Ziegler Wolfram , Schölderle Theresa , Brendel Bettina , Risch Verena , Felber Stefanie , Ott Katharina , Goldenberg Georg , Vogel Mathias , Bötzel Kai , Zettl Lena , Lorenzl Stefan , Lampe Renée , Strecker Katrin , Synofzik Matthis , Lindig Tobias , Ackermann Hermann , Staiger Anja
Published: January 2023

Nonspeech (or paraspeech) parameters are widely used in clinical assessment of speech impairment in persons with dysarthria (PWD). Virtually every standard clinical instrument used in dysarthria diagnostics includes nonspeech parameters, often in considerable numbers. While theoretical considerations have challenged the validity of these measures as markers of speech impairment, only a few studies have directly examined their relationship to speech parameters on a broader scale. This study was designed to investigate how nonspeech parameters commonly used in clinical dysarthria assessment relate to speech characteristics of dysarthria in individuals with movement disorders. Maximum syllable repetition rates, accuracies, and rates of isolated and repetitive nonspeech oral–facial movements and maximum phonation times were compared with auditory–perceptual and acoustic speech parameters. Overall, 23 diagnostic parameters were assessed in a sample of 130 patients with movement disorders of six etiologies. Each variable was standardized for its distribution and for age and sex effects in 130 neurotypical speakers. Exploratory Graph Analysis (EGA) and Confirmatory Factor Analysis (CFA) were used to examine the factor structure underlying the diagnostic parameters. In the first analysis, we tested the hypothesis that nonspeech parameters combine with speech parameters within diagnostic dimensions representing domain–general motor control principles. In a second analysis, we tested the more specific hypotheses that diagnostic parameters split along effector (lip vs. tongue) or functional (speed vs. accuracy) rather than task boundaries. Our findings contradict the view that nonspeech parameters currently used in dysarthria diagnostics are congruent with diagnostic measures of speech characteristics in PWD.
The Impact of Affective Temperaments on Suicidal Ideation and Behaviors: Results from an Observational Multicentric Study on Patients with Mood Disorders
Authors: Luciano Mario , Sampogna Gaia , Della Rocca Bianca , Simonetti Alessio , De Fazio Pasquale , Di Nicola Marco , Di Lorenzo Giorgio , Pepe Maria , Sambataro Fabio , Signorelli Maria Salvina , Koukopoulos Alexia Emilia , Delle Chiaie Roberto , Sani Gabriele , Fiorillo Andrea
Published: January 2023

Suicide ideation and behaviors are major health issues in the field of mental health. Several psychological and psychosocial factors have been taken into account as possible predictors of suicidality. Only recently affective temperaments have been considered as possible factors linked to suicide. This study aims to investigate the relationship between affective temperaments and suicidality, including the lifetime onset of suicide ideation, lifetime presence of suicide attempts and the total number of lifetime suicide attempts. This is a naturalistic multicentric observational study, involving outpatient units of seven University sites in Italy. Patients were administered with the short version of TEMPS-M and the Columbia Suicide Severity Rating Scale. A total of 653 participants were recruited, with a diagnosis of bipolar (55.7%), unipolar (35.8%) and cyclothymic disorder (8.4%). Regression models showed that the presence of lifetime suicide behaviors was increased in patients presenting trait related impulsivity (p < 0.0001), poor free-interval functioning (p < 0.05), higher number of affective episodes (p < 0.01), higher number of hospitalizations (p < 0.0001), cyclothymic and irritable affective temperaments (p < 0.05 and p < 0.05, respectively). Conversely, the presence of hyperthymic affective disposition reduced the likelihood of having suicidal behaviors (p < 0.01). Lifetime suicidal ideation was associated with trait-related impulsivity (p < 0.001), poor free-interval functioning (p < 0.05), higher number of affective episodes (p < 0.001) and of hospitalizations (p < 0.001). Depressive temperaments increased the likelihood of presenting suicidal ideation (p < 0.05), along with irritable temperaments (p < 0.01), contrary to hyperthymic affective (p < 0.05). Results of the present study confirm that affective disposition has a significant impact on the onset of suicidal ideation and behaviors, and that affective dispositions should be assessed in clinical settings to identify people at risk of suicide. Moreover, a wider clinical evaluation, including different clinical psychopathological dimensions, should be taken into consideration to develop effective preventive interventions.
Does Property Return Affect Seller Behavior? An Empirical Study of China’s Real Estate Market
Authors: Li Hongfei , Liang Limin , Sun Chengjiu
Published: January 2023

This paper examines the relationship between property return and seller behavior and aims to test the disposition effect in China’s real estate market. Using transaction data in Beijing, we find that loss properties have a lower sell propensity relative to gain properties, confirming the existence of the disposition effect. We also find that the disposition effect is more pronounced in samples with shorter holding periods. Sellers with financial constraints and popular projects are more likely to show the disposition effect. Furthermore, we find that sellers exhibit loss aversion; specifically, sellers with loss properties are likely to set a higher listing price, which provides indirect evidence for the disposition effect.
Perception of Size and Mass Relationships of Moving and Stationary Object in Collision Events in 10-to-11-Month-Old Infants
Authors: Sanal-Hayes Nilihan E. M. , Hayes Lawrence D. , Walker Peter , Mair Jacqueline L. , Bremner James Gavin
Published: January 2023

Around 5.5–6.5 months of age, infants first attend to object size and perceive its mass cues in simple collision events. Infants attend to the size of the moving object and expect a greater displacement following a collision with a large object and stationary object, and lesser displacement following a collision with a small object and stationary object. It has been proposed that infants of 6-to-7 months of age can differentiate between sizes of moving objects but do not perceive the size and mass relationships in simple collision events. The present two investigations aimed to investigate whether infants 10-to-11 months of age (N = 16) could perceive this relationship (experiment 1) and the reverse of this relationship (experiment 2) utilising the looking time paradigm. The reverse of this relationship entailed the circumstances in which the moving object size was kept constant, but the stationary object size varied (small or large). Results from these experiments revealed that infants did not differ in their looking times for size congruent and size incongruent distances in both conditions. Infants did not look longer at the incongruent test events that violated expectation. For that reason, we conclude infants of 10-to-11 months of age were unable to perceive size and mass associations in collision events in either direction (moving object or stationary object size).
How Does Collective Moral Judgment Induce Unethical Pro-Organizational Behaviors in Infrastructure Construction Projects: The Mediating Role of Machiavellianism
Authors: Xiong Qinqin , Pan Qi , Nie Shangyao , Guan Fei , Nie Xinyu , Sun Zhoubao
Published: January 2023

The sustainable development of infrastructure construction projects heavily depends on favorable cooperation of all parties and ethical code of conduct, while Un-ethical pro-organizational behavior (UPB) may undermine the mutual efforts and cause serious consequences. UPB has aroused wide interest of researchers, but what may trigger construction employees to engage in UPB at team-level has not been elucidated completely. With information asymmetry and huge uncertainty, the behaviors of employees in temporary project teams are marked by environmental and personal characters. The study discusses the influences of collective moral judgement focus on self (CMJS) and Machiavellianism on UPB. Through a moderated mediation analysis conducted on a set of survey data from Chinese construction projects, the empirical results of the two-level hierarchical linear model indicate that CMJS positively impacts UPB directly, and meanwhile Machiavellianism acts as a partial mediator in the relationship between CMJS and UPB. The findings also reveal that performance-avoidance goal orientation (PAGO) and motivation to learn (MTL) moderate and strengthen the relationship between Machiavellianism and UPB. The study offers practical suggestions for both project managers and policymakers of construction projects.
Holistic Approach towards a Sustainable Urban Renewal: Thermal Comfort Perspective of Urban Housing in Kigali, Rwanda
Authors: Irakoze Amina , Lee Kwanho , Kim Kee Han
Published: January 2023

Urban upgrading programs are implemented to enhance the living conditions in a city. However, the concept of to what extent the life of the targeted communities is improved remains contested and fluid. The purpose of this study was two-fold. First, it evaluated for the first time the indoor thermal conditions in the three main urban housing types in Kigali and analyzed whether the ongoing urban renewal takes into consideration occupant thermal comfort. Second, alternatives to improve thermal performance of urban housing were investigated and recommendations were given. Results indicate that modern urban housing performed significantly greater compared to other housing types, especially during daytime. Indoor thermal conditions in the planned low-income housing were no better—and, in fact, were slightly poorer—than in the informal settlement from which households were to be relocated. Through design parameter optimization, the indoor thermal conditions in the planned low-income housing were improved by 85.5% in the daytime hours and 71.2% in the nighttime hours. These findings are valuable to officials in resettlement programs by providing insights to improve urban dwellers’ living conditions from a wholistic prospective. This can assist related parties in mitigating project failure often caused by local resistance to resettlement.
Experimental Investigation on the Axial Compressive Behaviour of Cold-Formed Steel-Concrete Composite Columns Infilled with Various Types of Fibre-Reinforced Concrete
Authors: More Florence More Dattu Shanker , Subramanian Senthil Selvan
Published: January 2023

The exceptional structural strength and low cost of steel-concrete composite columns make them a popular choice for civil engineering structures. Numerous forms of composite columns, including steel tubes filled with concrete, have been produced recently in response to various construction situations. Cold-formed steel tubular columns with concrete filling have higher strength and ductility due to their capacity to withstand inner buckling and postpone outward buckling. The objective of this research is to determine the ductile and strength performance of composite columns containing various forms of fibre-reinforced concrete when subjected to axial compression. Several different kinds of fibre-reinforced concrete (FRC) are employed as additives in hollow steel columns, including steel FRC, carbon FRC, glass FRC, coir FRC, jute FRC, and sisal FRC. Axial compression tests were performed on 24 columns, including three hollow steel columns and 21 composite columns. Three distinct slenderness ratios were developed and used. Axial bearing capacity, compressive stress-strain curves, ductility, peak strain, axial shortening, and toughness were among the topics covered by the axial compression test. Experimental findings demonstrated that all conventional composite columns experienced failure through overall buckling, Local buckling and crushing of concrete infill, which was transformed into more ductile failure using fibre-reinforced concrete infills. The test results revealed that fibre-reinforced concrete-infilled steel columns outperformed conventional composite columns in terms of strength, ductility, and energy absorption capacity. The percentage increase in load-carrying capacity was observed as 203.88%, 193.48% and 190.03% when compared to hollow cold-formed steel tubular columns in medium, short and stub columns, respectively. Under assessment of stub, short, and medium columns, the load-strain plots demonstrated that the steel fibre-reinforced concrete in-filled columns performed well in terms of ductility. Localized buckling and crushing of the concrete infill caused the composite columns with low slenderness ratios to fail. In contrast, concrete-filled steel tube columns with higher slenderness ratios showed column failure through the overall buckling of the composite column.
Performance Analysis and Assessment of BIM-Based Construction Support with Priority Queuing Policy
Authors: Ham Nam-Hyuk , Yuh Ok-Kyung
Published: January 2023

A variety of methodological approaches have been developed to performance assessment for the adoption of building information modeling (BIM) at organizational and project levels. Recently, active research has been undertaken on the quantitative analysis of the effects of BIM on projects through BIM-based design validation methodologies. Nevertheless, few studies have addressed the interactions between the BIM staff providing BIM services and the project participants requesting BIM services from the viewpoint of micro-level management. In this study, with the aim of improving the performance of BIM-based construction support, we performed an analysis of the properties of the BIM request for information (RFI) in the construction phase, proposing a method for performance analysis and assessment which considers the competencies of the BIM staff that handle and process such requests. This study verified that, through the application of a priority policy according to the purpose of the information use in the construction phase, the performance of the BIM staff can be improved, and the waiting time of project participants to receive responses to the BIM RFIs can be reduced. The findings of this study are expected to be applied in areas such as decision making on allocation of BIM staff and analysis of return on investment (ROI) in hiring BIM services.
Metamodel-Based Hyperparameter Optimization of Optimization Algorithms in Building Energy Optimization
Authors: Si Binghui , Liu Feng , Li Yanxia
Published: January 2023

Building energy optimization (BEO) is a promising technique to achieve energy efficient designs. The efficacy of optimization algorithms is imperative for the BEO technique and is significantly dependent on the algorithm hyperparameters. Currently, studies focusing on algorithm hyperparameters are scarce, and common agreement on how to set their values, especially for BEO problems, is still lacking. This study proposes a metamodel-based methodology for hyperparameter optimization of optimization algorithms applied in BEO. The aim is to maximize the algorithmic efficacy and avoid the failure of the BEO technique because of improper algorithm hyperparameter settings. The method consists of three consecutive steps: constructing the specific BEO problem, developing an ANN-trained metamodel of the problem, and optimizing algorithm hyperparameters with nondominated sorting genetic algorithm II (NSGA-II). To verify the validity, 15 benchmark BEO problems with different properties, i.e., five building models and three design variable categories, were constructed for numerical experiments. For each problem, the hyperparameters of four commonly used algorithms, i.e., the genetic algorithm (GA), the particle swarm optimization (PSO) algorithm, simulated annealing (SA), and the multi-objective genetic algorithm (MOGA), were optimized. Results demonstrated that the MOGA benefited the most from hyperparameter optimization in terms of the quality of the obtained optimum, while PSO benefited the most in terms of the computing time.
Using the Dual Concept of Evolutionary Game and Reinforcement Learning in Support of Decision-Making Process of Community Regeneration—Case Study in Shanghai
Authors: Zhou Youmei , Lei Hao , Zhang Xiyu , Wang Shan , Xu Yingying , Li Chao , Zhang Jie
Published: January 2023

Under the digital revolution that spawned in recent years, AI support is raised in the context of urban design and governance as it aims to match the operation of the urban developing process. It offers more chances for ensuring equality in public participation and empowerment, with the possibility of projection and computation of integrated social, cultural, and physical spaces. Therefore, this research explored how scenario simulation of social attributes and social interaction dimensions can be incorporated into digital twin city research and development, which is seen as a problem to be addressed in the refinement and planning of future digital platforms and management in terms of decision-making. To achieve the research aim, this paper examined the evolution of social governance state and strain decision models, built a simulation method for the evolution of complex systems of social governance driven by the fusion of data and knowledge, and proposed a system response to residents’ ubiquitous perception and ubiquitous participation. The findings can help inspire the application of computational decision-making support in urban governance, and enhance the internal drive for comprehensive and sustainable urban regeneration. Moreover, they imply the role of the updated iterations of physical space and social interaction on social attributes.
Role of Etiology in Hepatocellular Carcinoma Patients Treated with Lenvatinib: A Counterfactual Event-Based Mediation Analysis
Authors: Sacco Rodolfo , Ramai Daryl , Tortora Raffaella , di Costanzo Giovan Giuseppe , Burlone Michela Emma , Pirisi Mario , Federico Piera , Daniele Bruno , Silletta Marianna , Gallo Paolo , Cocuzza Caterina , Russello Maurizio , Cabibbo Giuseppe , Rancatore Gabriele , Cesario Silvia , Masi Gianluca , Marzi Luca , Mega Andrea , Granito Alessandro , Pieri Giulia , Giannini Edoardo G. , Paolillo Rosa , Gadaleta-Caldarola Gennaro , Dadduzio Vincenzo , Giordano Guido , Giacomelli Luca , Papa Simonetta , Renzulli Matteo , Maida Marcello , Ghidini Michele , Borzio Mauro , Facciorusso Antonio
Published: January 2023

Background: Whether the etiology of underlying liver disease represents a prognostic factor in patients with hepatocellular carcinoma (HCC) treated with lenvatinib is still a matter of debate. This study investigates whether the viral etiology of HCC plays a prognostic role in overall survival (OS). Methods: Data derived from a multicenter series of 313 HCC patients treated with lenvatinib between 2019 and 2022 were analyzed. Actuarial survival estimates were computed using the Kaplan–Meier method and compared with the log-rank test. We performed an event-based counterfactual mediation analysis to estimate direct (chronic inflammation and immunosuppression), indirect (tobacco smoking, alcohol use, illicit drug abuse with injections), and the total effect of viral etiology on OS. Results were expressed as hazard ratio (HR) and 95% CI. Results: Median OS was 21 months (95% CI: 20–23) in the group with other etiologies and 15 months (14–16) in the group with viral etiology (p < 0.0001). The total effect of viral etiology was associated with OS (HR 2.76, 1.32–5.21), and it was mainly explained by the pure direct effect of viral etiology (HR 2.74, 1.15–4.45). By contrast, its total indirect effect was not associated with poorer survival (HR 1.05, 0.82–2.13). These results were confirmed when considering tobacco, alcohol consumption, or injection drug abuse as potential mediators. Median progression-free survival was 9 months (8–10) in patients with other etiologies and 6 months (5–7) in patients with viral etiology (p < 0.0001). No difference in terms of adverse event rate was observed between the two groups. Conclusions: Patients affected by HCC with nonviral etiology treated with lenvatinib exhibit longer survival than those with viral etiology. This finding may have relevance in the treatment decision-making process.
TIM-3 Is a Potential Immune Checkpoint Target in Cats with Mammary Carcinoma
Authors: Valente Sofia , Nascimento Catarina , Gameiro Andreia , Ferreira João , Correia Jorge , Ferreira Fernando
Published: January 2023

Recent findings in human breast cancer (HBC) indicate that T-cell immunoglobulin and mucin-domain-containing molecule-3 (TIM-3)-targeted therapies may effectively activate anticancer immune responses. Although feline mammary carcinoma (FMC) is a valuable cancer model, no studies on TIM-3 have been developed in this species. Thus, we evaluated the expression of TIM-3 by immunohistochemistry in total (t), stromal (s), and intra-tumoral (i) tumor-infiltrating lymphocytes (TILs) and in cancer cells, of 48 cats with mammary carcinoma. In parallel, serum TIM-3 levels were quantified using ELISA and the presence of somatic mutations in the TIM-3 gene was evaluated in 19 tumor samples. sTILs-TIM3+ were more frequent than iTILs-TIM-3+, with the TIM-3 ex-pression in sTILs and cancer cells being associated with more aggressive clinicopathological features. In contrast, the TIM-3 expression in iTILs and tTILs was associated with a more benign clinical course. Moreover, the serum TIM-3 levels were lower in animals with FMC when compared to healthy animals (p < 0.001). Only one somatic mutation was found in the TIM-3 gene, at intron 2, in one tumor sample. Altogether, our results suggest that the expression of TIM-3 among TILs subpopulations and cancer cells may influence the clinical outcome of cats with FMC, in line with the previous reports in HBC.
Multiomics Analysis Reveals Cuproptosis-Related Signature for Evaluating Prognosis and Immunotherapy Efficacy in Colorectal Cancer
Authors: He Rong , Zhang Heping , Zhao Huaxin , Yin Xiaolan , Lu Jingyi , Gu Cheng , Gao Jie , Xu Qing
Published: January 2023

Cuproptosis is a copper-induced form of mitochondrial cell death which is engaged in the proliferation and migration of a variety of tumors. Nevertheless, the role of cuproptosis in tumor microenvironment (TME) remodeling and antitumor therapy is still poorly understood. We characterized two diverse cuproptosis-associated molecular isoforms in CRC which exhibit distinct prognostic and TME characteristics. Subsequently, we constructed a cuproptosis-associated prognostic model containing five genes and divided the patients into a high CPS-score group and a low CPS-score group. Univariate and multivariate Cox analyses showed that the CPS score could be used as an independent prognostic factor. The nomogram, and its consequent calibration curves, indicated that this prognostic signature had good predictive power for CRC. The analysis of single-cell sequencing data showed the significant expression of HES4 and SPHK1 in various immune and stromal (including fibroblasts) cells. Further studies showed that tumor mutational burden (TMB), high microsatellite instability (MSI-H) ratio, immune checkpoint blockade (ICB), and human leukocyte antigen (HLA) gene expression all positively correlated with the CPS score, predicting a better reaction to immunotherapy in high CPS-core patients. The CPS score constructed from cuproptosis subtypes can be used as a predictive tool to evaluate the prognosis of CRC patients and their response to immunotherapy.
Sentinel Lymph Node Biopsy in Uterine Cancer: Time for a Modern Approach
Authors: Laas Enora , Fourchotte Virginie , Gaillard Thomas , Pauly Léa , Reyal Fabien , Feron Jean-Guillaume , Lécuru Fabrice
Published: January 2023

Since the validation of the sentinel node technique (SLN) for vulvar cancer 20 years ago, this technique has been introduced in the management of operable cervical cancer and endometrial cancer. For cervical cancer a “one fits all” attitude has mainly been presented. However, this approach, consisting of a frozen section during the operation, can be discussed in some stages. We present and discuss the main option for each stage, as well as some secondary possibilities. For endometrial cancer, SLN is now the technique of choice for the nodal staging of low- and intermediate-risk groups. Some discussion exists for the high-risk group. We also discuss the impacts of using preoperatively the molecular classification of endometrial cancer. Patients with POLE or TP53 mutations could have different nodal staging. The story of SLN in uterine cancers is not finished. We propose a comprehensive algorithm of SLN in early cervical and endometrial cancers. However, several ongoing trials will give us important data in the coming years. They could substantially change these propositions.