bluuebunny/crossref_metadata_2025 huggingface dataset:
Complications due to Biliary Stent Deviation
Authors:   Department of Gastroenterology, Oita University, Oita, Japan, Kumar Kinoshita , S Fukuchi ,   Department of Gastroenterology, Oita University, Oita, Japan, K Murakami ,   Department of Gastroenterology, Oita University, Oita, Japan
Published: June 2021

We often encounter complications from biliary stents used as a treatment for obstructive jaundice and acute cholangitis. Early complications after stent placement include pancreatitis, bleeding, and duodenal perforation [1]. Stent deviation is also a complication. This is particularly prominent for plastic stents, where stent deviation is observed in 6-18.7 % of cases [2]. Stent deviation is more common among patients who have undergone endoscopic sphincterotomy (Figure 1). Most deviated biliary plastic stents are excreted in stool or collected endoscopically, but, very rarely, complications causing gastrointestinal perforation have been reported. We have described deviated biliary plastic stents causing sigmoid colon diverticulum perforation and even uterine appendage penetration (Figure 2). Diagnosis can be made from clinical symptoms and abdominal computed tomography. Treatment is basically surgery. Biliary stent-related complications are inevitable, and sometimes become serious. On suspicion of such complications, the most important issue is to accurately and rapidly diagnose complications and conduct appropriate management.
Synthesis, characterization, molecular docking and in vitro anticancer activity of 3-(4-methoxyphenyl)-5-substituted phenyl-2-pyrazoline-1- carbothioamide
Authors: Benupani Sahu  , Rajapandi R  , Avik Maji  , Abhik Paul  , Tanushree Singha  , Tapan Kumar Maity
Published: June 2021

In the present study, eight numbers of new 3- (4-methoxy phenyl)-5-substituted phenyl-2-pyrazoline-1-carbothioamide (5a-h) have been synthesized from 1- (4-methoxy phenyl)-3- (substituted phenyl)-prop-2-en-1-one (3a-h) and structurally characterized by using FT-IR, 1H NMR, 13C NMR, Mass and Elemental analysis. The synthesized molecules were biologically evaluated for their in vitro anticancer activity against human breast adenocarcinoma (MCF-7), liver cancer (Hep-G2) and leukaemia cancer (K-562) cell line using Sulforhodamine B (SRB) bioassay technique. From the all synthesized compounds 5a, 5c, 5d, and 5e exhibited potent anticancer activity (GI50= <10µg/ml) as compared to the controlled drug 5-Fluorouracil (5-FU) (GI50=44.5µg/ml) and Adriamycin (ADR) (GI50= <10µg/ml) on MCF-7 cell lines. Besides this, all the synthesized compounds have exhibited moderate activity against human liver cancer (Hep-G2) and leukaemia cancer (K-562) cell lines. In addition, molecular docking studies were also explored in order to study the probable binding specificity into the active site of Epidermal Growth Factor Receptor tyrosine kinase (EGFR) (PDB ID: 1M17) using Molegro Virtual Docker Evaluation 2013 6.0.1 (MVD). Based on the molecular docking result, it was found that compound 5a exhibited the best interaction with the above target (i.e., EGFR) by interacting with specific amino acid residues such as: Thr 766, Gin 767, Thr 830, Cys 575, Ala 719 and Met 769.
Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19
Authors: Lazari Lucas Cardoso , Ghilardi Fabio De Rose , Rosa-Fernandes Livia , Assis Diego M , Nicolau José Carlos , Santiago Veronica Feijoli , Dalçóquio Talia Falcão , Angeli Claudia B , Bertolin Adriadne Justi , Marinho Claudio RF , Wrenger Carsten , Durigon Edison Luiz , Siciliano Rinaldo Focaccia , Palmisano Giuseppe
Published: June 2021

SARS-CoV-2 infection poses a global health crisis. In parallel with the ongoing world effort to identify therapeutic solutions, there is a critical need for improvement in the prognosis of COVID-19. Here, we report plasma proteome fingerprinting that predict high (hospitalized) and low-risk (outpatients) cases of COVID-19 identified by a platform that combines machine learning with matrix-assisted laser desorption ionization mass spectrometry analysis. Sample preparation, MS, and data analysis parameters were optimized to achieve an overall accuracy of 92%, sensitivity of 93%, and specificity of 92% in dataset without feature selection. We identified two distinct regions in the MALDI-TOF profile belonging to the same proteoforms. A combination of SDS–PAGE and quantitative bottom-up proteomic analysis allowed the identification of intact and truncated forms of serum amyloid A-1 and A-2 proteins, both already described as biomarkers for viral infections in the acute phase. Unbiased discrimination of high- and low-risk COVID-19 patients using a technology that is currently in clinical use may have a prompt application in the noninvasive prognosis of COVID-19. Further validation will consolidate its clinical utility.
PREDICTION OF FINANCIAL DISTRESS: CASE OF MINING ENTERPRISES IN CZECH REPUBLIC
Authors: Rowland Zuzana , Kasych Alla , Suler Petr
Published: June 2021

The ability to predict a company's financial health is a challenge for many researchers and scientists. It is also a distracting topic, as many other new approaches to financial health predictions have emerged in recent years. In this paper, we focused on identifying the financial health of mining companies in the Czech Republic. We chose the neural network method because, based on various instances of related research, neural networks represent a more reliable financial forecast than mathematical-statistical methods such as discriminant analysis and logistic regression. The concept of a neural network emerged with the first artificial neural networks, inspired by biological systems. The existence of prediction and classification problems directly predetermines artificial neural networks with respect to a given issue. We used the Amadeus database for processing, including financial indicators, SPSS, and Visual Gene Developer software. In total, we analyzed sixty-four mining companies. Complete data on financial stability were available for fifty-three companies, which we explored, and based on these results, identified financial situations for the other thirteen. Based on the available information, we processed a neural network and regression analysis. We managed to classify thirteen companies as solvent, insolvent, and in the grey zone, with the help of prediction.
MANAGERIAL EVALUATION OF THE LOGISTICS PERFORMANCE AND ITS DEPENDENCIES ON ECONOMIES IN SELECTED COUNTRIES
Authors: Filova Alexandra , Hrda Veronika
Published: June 2021

The objective of the paper is managerial evaluation of the level of logistics on individual continents and to find out dependence between the level of logistic systems and the level of GDP in the selected countries of the world. To evaluate logistics, we used the Logistics Performance Index and its six categories (customs clearance, infrastructure, international shipment, logistic competencies, monitoring shipment, and satisfaction). The index of gross domestic product was shown per capita and in constant U.S. dollars for 2010. The analyzed period was the years 2010, 2012, 2014, 2016, and 2018. Together, we analyzed 134 countries from five of the world’s continents. Results are provided separately for the European countries and the Slovak Republic. To find out mutual linear dependence, we used the correlation coefficient. From the results of the research, it is clear that there is a connection between the variables LPI and GDP and thus that there exists a direct linear dependence. Only in one case, that of the African continent in 2018, was the coefficient of correlation close to zero and we had to state that the variables were not linearly dependent. For most resulting values of the correlation coefficient, we found only slight linear dependence. The exception was the countries of Australia and Oceania, where a strong dependence was found for all the years in question. This kind of analysis has significance primarily on the macroeconomic level. The individual countries can investigate, evaluate, and consequently improve their respective logistic systems and services. Understanding and decomposing the components of trade and logistics performance can help countries improve freight transport efficiency and identify where international cooperation could help overcome barriers.
DIGITAL HUMAN SKILLS FORM THE CORPORATE ECONOMY AND BUSINESS DEVELOPMENT
Authors: Malkawi Elena , Khayrullina Marina
Published: June 2021

Digitalization, intensified by the COVID-19 pandemic, presents great opportunities for economic growth and development of businesses. At the same time, it brings challenges such as new requirements for human skills. To facilitate digital transition in the corporate sector and obtain its benefits, there is high demand for people skilled in the existing digital technologies and able to adapt to changes quickly. Digital transformation demands lifelong learning and reinforces the link between education, training, and work. Educators and other professionals in the field need to adjust to being “twenty-first century educators” and to consider a range of new digital skills that will allow students to develop a variety of professional and personal abilities. To examine human skills required by digitalization, this study set out to investigate elements of an existing digital learning environment in a university based on feedback from its 2020 spring term students. The research is grounded in a social cognitive perspective of self-regulation and in recent contributions from the multidisciplinary humancomputer interaction (HCI) field. The data came from the total of 2,347 university students, was collected through an online survey, evaluated using the SPSS software, and qualitatively analyzed. The study revealed that students pinpointed three groups of problems in online learning: the process of concentration and self-regulation; the process of getting feedback from tutors and peers; and technical difficulties with staying connected. The researchers attempted to shed light on self-regulation as an essential human skill that is required for successful business and corporate development in the digitalized environment.
Age-Related Changes in Circadian Rhythms and Their Effects on Cognition and Psychological Well-Being: A Literature Review
Authors: McMahon Aoife , Tolentino Raymond , Thum Phoebe
Published: June 2021

Introduction: Circadian rhythms, the internal “clocks” that control a variety of physiological processes, have been found to change considerably throughout one’s lifetime. Young adults tend to be more “evening” people, while older adults tend to be more “morning” people due to age-related changes in their sleep-wake cycles. This review aims to discuss the corresponding physiological and psychological changes that occur due to the changing circadian rhythms that come with age.
Methods: A literature search was conducted using the databases PubMed, PsycINFO, and AgeLine. Keywords included variations of “circadian rhythms”, “aging”, “chronotype”, “cognition”, “depression”, “mood”, “bipolar disorder”, and “anxiety”. Studies were selected and findings regarding the physiological and psychological changes due to circadian rhythms and aging were reviewed.
Results: Research shows that age-related disruptions in circadian rhythms are associated with cognitive and psychological decline. Diminished sleep quality is associated with older age, due to the aforementioned underlying dysregulated circadian rhythms. Sleep deprivation is associated with increased levels of fatigue, stress, and overall mood disturbances. Moreover, circadian rhythm abnormalities associated with old age are related to greater mood disturbances, depression, and anxiety.
Discussion: Poor sleep and older age are important factors that can negatively affect one’s mood and emotional well-being. It is imperative that healthcare providers consider these factors when consulting and treating patients. Populations such as shift workers have been found to have impaired levels of alertness, mood, memory, and cognitive performance due to their dysregulated circadian rhythms. Furthermore, time of day plays a crucial role in the educational success of children and adolescents. Young individuals with an evening chronotype are put at a disadvantage for early school start times due to their opposing optimal times of performance.
Conclusion: Circadian rhythm dysfunction that is commonly associated with aging has the potential to contribute to adverse outcomes in human health, including cognitive deficits and pathological conditions. Future research efforts should concentrate on further clarifying the relationship between changing circadian rhythms and its impact on psychological well-being.
Principles of digitalisation of the state economy
Authors: Pypenko Iryna Sergiivna , Melnyk Yuriy Borysovych
Published: June 2021

Background: The digitalisation of the world economy as a means of improving the quality of human life is becoming increasingly important. The essence of the digital economy is multifaceted and insufficiently studied, in particular, the concept of “digital economy” needs to be clarified, the principles for digitalisation of the economy for specific countries and ways to implement them need justification. Purpose: To explore the current trends for digitalisation of the world economy and on this basis to develop principles and ways to implement them at the state level. Materials and Methods: A set of theoretical methods was used: analysis of academic literature, current normative documents and draft legislative acts, as well as synthesis, comparison, generalization, systematization to define and substantiate the guiding principles for digitalisation of the economy and ways to implement them in Ukraine. Results: Current trends in the digitalisation of the world economy were studied. The essence of the concept of “digital economy” was clarified. We propose to understand the digital economy as a type of economic activity in the system of socio-behavioral and cultural relations with the use of digital technologies, characterized by the creation, collection, processing, storage, transfer and use of digitized resources. The guiding principles for digitalisation of the economy were justified: integrity, phasing, leading, innovation, adaptability, simplicity (accessibility). Ways of implementation were developed for each principle. They contain answers to key questions: what needs to be done? how to stimulate? what support should be provided by the state? Conclusions: This paper reveals the current trends of digitalisation of the world economy and provides responsible persons, who determine the country policy, the guiding principles for defining and implementing digitalisation strategies in the most appropriate sectors of the economy at the state level
Overview on intestinal transplantation: indications, techniques, outcomes, major advancements and future prospectives
Authors: Coco D. , Leanza S.
Published: June 2021

Overview on intestinal transplantation: indications, techniques, outcomes, major advancements and future prospectives
Combination of dermatotraction procedure and of the wound therapy, using negative pressure, in treatment of defects after the lower extremity fasciotomy
Authors: Zhydkov R. , Stashek M. , Ctirad P.
Published: June 2021

Combination of dermatotraction procedure and of the wound therapy, using negative pressure, in treatment of defects after the lower extremity fasciotomy
Reakcje duchowieństwa w Trójmieście na zapowiedzi normalizacji stosunków między państwem a Kościołem rzymskokatolickim po Grudniu ’70
Authors: Abryszeński Piotr , Gucewicz Daniel
Published: June 2021

Zmiany personalne na najwyższych stanowiskach państwowych wywołane brutalnym stłumieniem protestów w Grudniu ’70 spotkały się z pozytywną reakcją większości społeczeństwa, również duchownych Kościoła katolickiego. Jednak władze zdawały sobie sprawę, że nie wystarczy to do szybkiego uspokojenia nastrojów. Jednym z narzędzi służących legitymizacji nowej ekipy rządzącej stała się deklaracja gotowości do dialogu i normalizacji stosunków z Kościołem. Była ona sygnałem skierowanym zarówno do duchowieństwa, jak i do wiernych. Proces rozpoczęła wymiana korespondencji prymasa Stefana Wyszyńskiego z premierem Piotrem Jaroszewiczem, co otworzyło drogę do spotkań przedstawicieli Episkopatu Polski z przedstawicielami władz PRL. Rozmowy te przeniosły się również na poziom lokalny.

Deklaracje współpracy oraz towarzyszące im kurtuazyjne gesty zasadniczo spotykały się z zadowoleniem księży. Liczyli oni, że dzięki temu uda się pozytywnie zakończyć wiele nierozwiązanych dotychczas spraw i postulatów zgłaszanych władzom. Efektem rozmów było uregulowanie kwestii własności na Ziemiach Zachodnich i Północnych, uchylenie urzędowego obowiązku prowadzenia ksiąg inwentarzowych przez duchowieństwo czy realizacja części kościelnych postulatów dotyczących budownictwa sakralnego. Symbolem złagodzenia polityki władz była zgoda na budowę kościoła na gdańskim Przymorzu – dynamicznie rozwijającej się dzielnicy, której mieszkańcy od lat zabiegali o swoją świątynię. Znamienny był również zwrot kościoła św. Stanisława w Gdańsku‑Wrzeszczu na cele sakralne, o co bezskutecznie starano się od zakończenia wojny. Komuniści nie byli chętni do zbyt dużych ustępstw i stopniowo odzyskiwali kontrolę nad procesem normalizacji. Jednak nawet sam prymas Wyszyński dostrzegał pozytywne strony tego procesu.

Artykuł przedstawia pierwsze reakcje duchowieństwa w Trójmieście na normalizację stosunków między państwem a Kościołem rzymskokatolickim po rewolcie grudniowej 1970 r. Jest rozwinięciem i uzupełnieniem tez zawartych w książce Grudniowa kolęda. Kościół katolicki w Trójmieście wobec Grudnia ’70 (Gdańsk–Warszawa 2020).
Gdańska koncepcja praw człowieka. Szkic z filozofii praw człowieka wokół treści Karty Powinności Człowieka proklamowanej 2 września 2000 r. w Gdańsku
Authors: Snarski Tomasz
Published: June 2021

Artykuł stanowi próbę studium z filozofii praw człowieka w oparciu o treść Karty Powinności Człowieka (zamiennie: gdańskiej Karty) podpisanej i ogłoszonej 2 września 2000 r. w Gdańsku. W opracowaniu przedstawiono okoliczności opracowania i przyjęcia Karty, przeanalizowano jej postanowienia oraz zaproponowano w oparciu o nie zarys gdańskiej koncepcji praw człowieka. Autor rozważa również znaczenie gdańskiej Karty w kontekście kategorii pedagogiki miejsca sformułowanej przez Marię Mendel. Pośród różnych cech wyróżniających gdańską koncepcję praw człowieka za najistotniejszą uznać należy wzajemne konieczne powiązanie praw człowieka z określonymi wobec nich powinnościami, ujmowanymi jako wskazania moralnego postępowania. Co więcej, w ujęciu Karty Powinności Człowieka prawa człowieka mają wybitnie moralny charakter, stanowiąc w pierwszym rzędzie kategorię praw moralnych. Na podstawie interpretacji postanowień tegoż dokumentu można także mówić o zaniechaniu wypełnienia przez podmiot moralny powinności człowieka jako swoistym przypadku naruszenia praw człowieka.
México 2020: la pandemia del Sars-Cov-2 y sus diferentes tasas de intensidad. Algunas características sociodemográficas
Authors:   Universidad Autónoma del Estado de Hidalgo
Published: June 2021

La presente investigación tiene como finalidad analizar el impacto que ha tenido la pandemia del Sars-Cov-2 en las defunciones de mexicanos, especialmente aquellos que presentan ciertas comorbilidades, y la hipótesis que se manejó dentro de la presente investigación, plantea que son estas personas las que tienen una mayor probabilidad de complicación y de fallecimiento ante un contagio del Sars-Cov-2. La pandemia del COVID19 ha generado tasas de mortalidad diferenciando por sexo, edad, entre otras variables demográficas; sin embargo los recursos de atención médica, el distanciamiento social y las políticas de salud han causado grandes variaciones en el alcance y la dinámica de la pandemia en todas las naciones. Por ello se ha hecho difícil estimar la prevalencia, la tasa de mortalidad por infección y otros factores importantes para los proveedores de atención y los encargados de formular políticas públicas y de salud. Rahmandad, Lim y Sterman, estimaron la propagación a nivel mundial del COVID-19, para ello utilizaron los datos de 84 países, realizando pruebas confiables que incluyen 4.75 mil millones de personas y desarrollaron un modelo epidemiológico dinámico que integra datos sobre casos, muertes, exceso de mortalidad y otros factores para estimar cómo la transmisión asintomática, la agudeza de la enfermedad, la hospitalización y las respuestas conductuales y políticas influyen la prevalencia del COVID19. Para los países seleccionados ellos estimaron casos y defunciones hasta el 18 de junio del presente año; estimaron en 11.8 la tasa de mortalidad por infección y un error en la estadística de 1.48 veces los informes oficiales respectivamente. Afirman que en todas las naciones permanecen muy por debajo del nivel necesario para la inmunidad colectiva. También concluyeron que se hubiera alertado al público antes, con ellos se hubieran reducido los contactos y se podrían haber evitado 35.3 millones de casos y 197 mil muertes. Sin embargo, los resultados futuros dependen menos de las pruebas y más de la voluntad de las comunidades y los gobiernos de reducir la transmisión (Rahmandad, Lim y Sterman, 2020).
Project-Based Versus Traditional Lecture Teaching Methods
Authors: Hafeez Muhammad
Published: June 2021

To compete the world in 21st century, it is necessary to adopt the modern learning strategies like inquiry-based, project-based, problem-based. The traditional learning strategies are no viable now to improve the learning skills of the learners.  A review of previous studies on traditional lecture-based and project-based learning strategies has been conducted to evaluate the effectiveness of both learning strategies. The learning outcomes and statistical results of 15 previous published articles have selected for this review study. The learning outcomes and statistical results of previous literature indicated that all the studies showed the significant improvement in the learning and cognitive skills of the learners. The effectiveness of project-based teaching strategy in various educational levels are also described in the study.
From “The Saddest Story” to “A Tale of Passion”: Modernist Narrative Techniques and Themes in Ford Madox Ford’s The Good Soldier
Authors: CAN Taner
Published: June 2021

Modernist British fiction has been customarily associated with a small group of authors, including Virginia Woolf, James Joyce, D. H. Lawrence and Samuel Beckett and their experimental works. This highly exclusive view of modernism largely overshadowed the place and legacy of Ford Madox Ford, along with some of his contemporaries, in the history of modernist British fiction. Despite this neglect in critical trajectory, Ford’s works, in fact, anticipates the technical and thematic concerns of the modernist fiction in many ways. The aim of this paper is to explore Ford’s affinities with major modernist writers through a comprehensive analysis of his 1915 novel The Good Soldier: A Tale of Passion. The subtitle of the novel “A Tale Passion” provides the necessary critical framework for literary analysis with its implications about Ford’s theory of the novel. Accordingly, the first part of the article focuses on the narrative strategies inspired by the definition of ‘tale’ and explores how Ford’s impressionistic writing style challenges the established conventions of the nineteenth century realism. The second part discusses the way Ford employs the theme of destructive passion to explore the overarching themes of shifting sense of morality and class as well as the political turmoil in the pre-war period.
Gadolinium Orthovanadate GdVO4:Eu3+ Nanoparticles Ameliorate Carrageenan-Induced Intestinal Inflammation
Authors: Tkachenko Anton , Pogozhykh Denys , Onishchenko Anatolii , Myasoedov Valeriy , Podrigalo Leonid , Klochkov Vladimir , Chumachenko Tetyana , Prokopyuk Volodymyr , Yefimova Svetlana , Gubina-Vakulyck Galina , Kavok Nataliya , Butov Dmytro , Andrieiev Andrii , Polikarpova Hanna , Nakonechna Oksana
Published: June 2021

Gadolinium orthovanadate GdVO4:Eu3+ nanoparticles (VNPs) have been shown to scavenge reactive oxygen species (ROS), making them a promising therapeutic agent in inflammation. This study aims to assess the effects of VNPs administered orally on E407a-induced inflammation. Materials and Methods: Fragments of the small intestine of 8 rats treated orally with a carrageenan-containing food additive E407a at a dose of 140 mg / kg of weight during 2 weeks, 8 animals orally exposed to both E407a and VNPs at a dose of 20 μg / kg of weight during the same period of time, and 8 control rats were stained routinely and immunostained for CD3 and CD68 with the subsequent immunohistochemical scoring. Moreover, analysis of viability and cell death modes of granulocytes was performed by flow cytometry using Annexin V and 7-aminoactinomycin D (7-AAD). Results: Oral exposure to the food additive E407a resulted in the development of enteritis associated with altered small intestinal morphology, infiltration of the lamina propria with macrophages and T-lymphocytes, and activation of peripheral blood granulocyte apoptosis. VNPs administered against the background of E407a-induced slight intestinal inflammation improved small intestinal morphology, decreased infiltration rate of the immune cells mentioned above without affecting the intensity of granulocyte apoptosis. Conclusion: Oral administration of VNPs ameliorates E407a-induced enteritis.
The relationship of HbA1c levels with creatinin levels in diabetes mellitus type 2 patients
Authors: Cahyani Putri Nur , Martsiningsih Atik , Setiawan Budi
Published: June 2021

Background: People with Type 2 Diabetes Mellitus in Indonesia continue to increase in prevalence. Understanding of complications due to this disease, one of which is diabetic nephropathy or damage to kidney nephrons. Objective: To determine the relationship between HbA1c levels and creatinine levels in patients with Type 2 Diabetes Mellitus. Method: This study was an observational experiment using a cross sectional approach based on secondary data. The research was carried out in February to April 2020. The population of this research study is a member of Prolanis (Chronic Disease Management Advanced Program) in Gamping 1 Puskesmas Sleman Yogyakarta. Sample with 24 patients. Analysis of data using the Spearman’s test. Results: From the results of the normality test using the Shapiro Wilk test data obtained were not normally distributed so that continued with the Spearman rank test obtained r of -0.006 and p values with sig. (2-tailed) of 0.961 or> 0.05 (H0 received). This means that there is no relationship between HbA1c levels and blood creatinine levels in patients with type 2 DM. Conclusion: There is no relationship between HbA1c levels and creatinine levels in patients with Type 2 Diabetes Mellitus.
Efektivitas pengomposan sampah organik menggunakan electrical rotary aerobic composter (ERAC)
Authors: Iswanto Iswanto , Puspawati Catur , Suwerda Bambang
Published: June 2021

Organic waste that produced in The Polytechnic Health Yogyakarta campus has not been processed and just disposed to Piyungan Landfill. To recycle the organic waste is required engineering technology that can produce compost quickly. Electrical Rotating Aerobic Composter (ERAC) is an aerobic powered electric composter model that is designed to rotate continuously for maintaining the stability of environmental factors (oxygen, temperature, humidity) and the homogeneity of processed organic matter. This study aims to determine effect and effectiveness of rotation speed of the ERAC on duration and quality of compost. This research is an experiment with Post-Test Design Only with Control Group Design. The sample of this research is organic waste that taken by proportionate stratified random sampling in The  Polytechnic Health Yogyakarta campus.  The composition of organic materials filled in the ERAC consist of 1 part organic waste from the canteen, 1 part of the yard / garden waste, 1 part of cattle manure and 5% active bioactivator. Rotation speed of the ERAC was set with variations: A = 0.20 rpm; B = 0.10 rpm; C = 0.05 rpm; K = 0.00 rpm (control). Each treatment was repeated 3 times and monitored daily until compost was formed. Compost samples are sent and checked for quality in the laboratory. Based on the physical parameters (temperature, color, texture and smell) of compost, showed that ERAC is able to process organic waste into compost within 7 days or four times faster than control (28 days). However, the variation of rotation speed was not significantly affect duration of composting. The quality of compost that produced by ERAC has fulfilled SNI No. 19-7030-2004 including  C/N ratio, water content, N, P, K and C-organic. The compost quality according to rotation speed of the ERAC (0,20 rpm; 0,10 rpm; 0, 05 rpm, control (0.00 rpm))  respectively are: C / N ratio (19,83,19,84,19,95,19,90); water content (11,36%; 10,81%; 10,83%; 10,97%); N (1.00%; 1.06%; 1.11%; 1,024%); P (0,57%; 0,60%; 0,58%; 0,64%); K (1.37%; 1.32%; 1.30%; 1.28%); C-organic (19.69%; 20,99%; 21,90%; 20,18%).The result of statistical analysis with Kruskal Wallis test with SPPS program version 16 showed that water content, N, P, C-organic and C / N ratio between the three variations of rotation speed of ERAC is not significantly different, except K level. But when it was associated with workload of the ERAC engine, the lowest rotation speed (0.05 rpm) is the most effective.
Terima kasih kepada mitra bebestari pada tahun 2018
Authors: ARSHI Veterinary Letters Editor
Published: June 2021

Proses telaah naskah dalam suatu jurnal ilmiah merupakan hal yang sangat penting untuk penjaminan mutu kualitas yang terbaik atas naskah yang dipublikasikan. Naskah yang telah berhasil dipublikasikan pada tahun 2018 berjumlah 40 dengan jenis tulisan studi kasus 26 naskah, 13 naskah hasil penelitian, dan 1 naskah tentang catatan teknis. Editor mengucapkan banyak terima kasih kepada para mitra bebestari atas kerjasama, curahan waktu, dan dedikasinya yang diberikan untuk eksistensi jurnal ini pada tahun 2018 lalu, yaitu:Erwin, .;Lestari, Citra Ayu;Noviana, Deni;Sudisma, I Gusti Ngurah;Ulum, Mokhamad Fakhrul;Winarso, Aji.
Efektivitas antimikroba terhadap Pasteurella multocida dan Mannheimia haemolityca dari sapi yang diduga menderita bovine respiratory disease kompleks
Authors: Klobongona Maria Luisa MNB , Afiff Usamah , Rotinsulu Dordia Anindita
Published: June 2021

Penelitian ini bertujuan untuk mempelajari efektivitas beberapa jenis antibiotik terhadap Pasteurella multocida dan Mannheimia haemolityca dari sapi yang diduga menderita Bovine Rsepiratory Disease complex (BRD complex). Isolat diperoleh dari paru-paru sapi. Identifikasi bakteri menunjukkan adanya bakteri yang umum terlibat pada kasus BRD complex  seperti P. multocidadan M. haemolityca. Uji sensitivitas antimikroba dilakukan terhadap tujuh antibiotik (bacitracin, vancomicin, oxytetracycline, enrofloxacin, gentamicin, ampicillin, dan erythromycin) menggunakan metode Kirby-Bauer dengan mengukur diameter zona hambat. Interpretasi standar yang digunakan didasarkan pada Clinical Laboratory Standards Institute (CLSI). Hasil penelitian menunjukkan bahwa isolat P. multocida sensitif terhadap enrofloxacin, oxytetracycline, gentamicin, dan ampisilin; resisten terhadap bacitracin dan vankomisin; ke eritromisin. Sedangkan isolat M. haemolityca sensitif terhadap enrofloxacin dan gentamicin; resisten terhadap bacitracin, vankomisin, oksitosin ampisilin, dan eritromisin
Efektifitas penggunaan filgastrim untuk terapi leukopenia pada kasus infeksi canine parvovirus
Authors: Sajuthi Tiara Putri , Fauzia Anisa Hasby , Widjanarko Christophorus Algriawan Bayu
Published: June 2021

Canine parvovirus (CPV) adalah salah satu penyakit infeksius pada anjing dengan angka morbiditas dan mortalitas yang tinggi. Infeksi CPV umumnya menyerang organ sistem pencernaan sehingga mengakibatkan gejala klinis berupa muntah dan diare. Organ lain yang diserang oleh virus ini antara lain sumsum tulang, sistem limfatik, dan myocardium (terutama pada hewan muda). Salah satu gejala klinis yang kerap muncul adalah leukopenia akibat perusakan prekursor leukosit dan sel-sel limfoid oleh virus. Filgastrim (Leucogen®) adalah rekombinan Human Granulocyte – Colony Stimulating Factor (rH G-CSF) yang berfungsi menstimulasi proliferasi dan diferensiasi sel-sel granulosit. Tiga ekor anjing ras Cocker Spaniel (a) (2 tahun), Bernese Mountain (b) (6 bulan), dan mixed breed (c) (3 bulan) dibawa ke PDHB 24 Jam drh. Cucu K. Sajuthi, dkk. dengan kondisi klinis anorexia, lethargy, vomit, melena, dan dehidrasi. Uji rapid test kit CPV menunjukan interpretasi positif. Pemeriksaan darah lengkap menunjukan nilai WBC 2 x 103/µL (a); 3,5 x 103/µL (b); dan 3,6 x 103/µL (c), serta nilai absolut granulosit 1,1 x 103/µL (a); 2,1 x 103/µL (b); dan 2,6 x 103/µL (c). Ketiga pasien diberikan terapi filgastrim (10 µg/kg/hari) selama tiga hari berturut-turut bersama dengan terapi suportif lainnya. Darah lengkap kembali dilakukan pemeriksaan dan menunjukan nilai WBC 5,8 x 103/µL (a); 9,7 x 103/µL (b); dan 51,4 x 103/µL (c) serta nilai absolut granulosit 3,4 x 103/µL (a); 7,3 x 103/µL (b); dan 42,5 x 103/µL (c). Terapi menggunakan filgastrim pada ketiga pasien menunjukkan peningkatan kondisi yang nyata terhadap gejala leukopenia. Pasien juga menunjukan perbaikan kondisi klinis yang signifikan membaik.
Khasiat fluralaner terhadap kutu keras (Rhipicephalus sanguineus) pada anjing
Authors: Hadi Upik Kesumawati , Soviana Susi , Bin Kamiring Azery , Hidayat Syarif
Published: June 2021

Fluralaner is a new molecular entity from the isoxazoline class that exhibits acaricidal and insecticidal activity and it is recommended as an anti-ticks drugs. The aim of this study is to analyze the effect of fluralaner against dog infested by tick. A total of 10 dogs weighing about 20-40 kg which consists of various races, were divided into control groups with-out medication (n=2), and treatment group (n=8) received fluralaner tablets once by orally, at a dose of 25 mg / kg body weight. The results showed that based on observation of day of drug application at 24th hour was the time where the drug reaches the standard of efficacy with decrease number of the tick by 97.3%. In 28 and 56 days post treatment were the highest levels of efficacy with a decrease number of tick reaching 100%. The efficacy of the fluralaner was still very high until 84 days post treatment reached up to 94.1%. This study also proved that 12 weeks of drug work believed to overcome reinfestation of the tick. The rapid tick-killing effect and the long duration of efficacy showed the potency fluralaner to aid in the prevention of tick borne diseases.
O ENSINO DE ECOLOGIA NA PERSPECTIVA DE PROFESSORES DA REGIÃO AMAZÔNICA
Authors: Pereira Carmel do Nascimento , Melo Eloídes de Sousa , NASCIMENTO GISELE DE ALMEIDA , Vasconcelos Elizandra Rêgo
Published: June 2021

à biodiversidade animal e vegetal. Devido ao o desenvolvimento
econômico, científico e tecnológico em ascensão na região, surgem os problemas
socioambientais que implicações entre os movimentos sociai
Movimentos familiares
Authors: Naranjo Diego , Naranjo Cláudia
Published: June 2021

Se examinarmos os inúmeros planos de pastoral, desde os da CNBB até os Paroquiais, em número assaz considerável - para não dizer na maioria deles - aparece a família como uma das prioridades...
“Ama e faze o que quiseres”
Authors: Meulenberg Leonardo
Published: June 2021

Acontece que os homens têm sonhos. Eles pensam num ideal a ser realizado. E isso é, de fato, um estímulo indispensável para continuar a luta por uma vida digna, pelo reino da justiça, da fraternidade e do amor. Mas parece que é preciso tomar cuidado. Pois às vezes a visão é tão universal, abrangente, que a gente se assusta. Até onde nos leva uma tal idéia? E nesta altura um fracasso qualquer vai confirmando aquela apreensão. O medo se apodera de nós. E aos poucos se perde a esperança. Mais ainda. Acontece que acabamos trancados dentro da nossa preocupação com a própria sorte...
Fundamentals of Diabetic Cataractogenesis and Promising Ways of its Pharmacological Correction
Authors: Spassov A. A. , Naumenko L. V. , Govorova Yu. A.
Published: June 2021

Cataracts in diabetes mellitus lead to decreased visual function and blindness. Cataract surgery for diabetes mellitus has limitations and complications. The search for effective means of conservative cataract therapy continues. The review presents the analysis of data from scientific sources, mainly for 2015–2020 using Internet resources (PubMed, Web of Science, Medline, eLibrary.Ru, Cyberleninka). In the work, diabetic cataractogenesis is presented as a sum of interrelated pathobiochemical processes. The main ones are the polyol pathway of glucose conversion, non-enzymatic glycation and oxidative modification of lens proteins, which are enhanced in diabetes mellitus. The lens has a high protein content. The formation of high molecular weight protein aggregates is of particular importance for the appearance of light scattering zones and a decrease in lens transparency. This review presents data on anti-cataract compounds that affect post-translational crystallin modification, prevent osmotic and oxidative stress in the lens, and exhibit antiglycation properties. This information shows that the search for means of pharmacological correction of cataractogenesis should be carried out among compounds with antioxidant and antiglycation activity.
Cellular Technologies in Traumatology: From Cells to Tissue Engineering
Authors: Dremina N. N. , Trukhan I. S. , Shurygina I. A.
Published: June 2021

Injuries and degenerative changes of tendons are common damages of the musculoskeletal system. Due to its hypovascular character the tendon has a limited natural ability to recover. For typical surgical treatment, the tendon integrity is restored, but in most cases, there occurs formation of the connective tissue scar resulting in structural and mechanical functionality disruption. The insufficient effectiveness of traditional therapy methods requires the search for alternative ways to restore damaged tendon tissues. This article discusses new effective methods for improving the treatment that base on the use of cellular technologies among which one of the main directions is mesenchymal stem cell application. Due to mesenchymal stem cells, there is a shift from pro-fibrotic and pro-inflammatory reactions of cells to pro-regenerative ones. Stem cells being multipotent and having among other things tenogenic potential are considered a promising material for repairing damaged tendons. The article also describes the sources of progenitor tendon cells including the tendon bundles and pericytes the main markers of which are Scx and Mkx that are proteins of the transcription factor superfamily, and Tnmd that is transmembrane glycoprotein.

The growth factors that not only enhance the proliferative activity of mesenchymal stem cells but also promote in vitro tenogenic genes expression as well as the collagen Itype production what is necessary for tendon formation are considered. Along with growth factors, the morphogenetic protein BMP14 is presented, this protein increases themesenchymal stem cell proliferation and contributes directed tenogenic differentiation of these cells, suppressing their adipogenic and chondrogenic potentials.

In recent years, mesenchymal stem cells have been used both separately and in combination with various growth factors and different three-dimensional structures providing the interaction with all of the cell types.

The issues of the latest 3D-bioprinting technology allowing to make tissue-like structures for replacement damaged tissues and organs are discussed. 3D-bioprinting technology is known to allow acting exact spatio-temporal control of the distribution of cells, growth factors, small molecules, drugs and biologically active substances.
Epidemiological Risk of Dirofilariasis in the Voronezh Region
Authors: Bespalova N. S. , Zolotykh T. A.
Published: June 2021

Background. Dirofilariasis is a vector-borne helminthiasis that tends to expand spatial boundaries in areas with temperate and cold climates. In the Voronezh oblast, located in the Central Black Earth Region of the Russian Federation there were previously isolated reports of cases of dirofilariasis in humans and dogs, but this issue was not specifically studied.

Aims. To determine the degree of infection of dogs with Dirofilaria immitis and Dirofilaria repens in the Voronezh oblast in order to determine the level of epidemiological risk.

Materials and methods. For seven years, targeted work was carried out to study the spread of different types of dirofilariae in dogs in the Voronezh region. Blood from 3 498 dogs of different breeds, ages, conditions of keeping and household use was examined. Dirofilaria larvae were counted using the Fuchs-Rosenthal camera. The type of dirofilaria larvae isolated from the blood of dogs was determined by the histochemical method. The antigen of the imaginal form of D. immitis was detected using a chromatographic test system the ImmunoRun Antigen Detection Kit Caninae Heartworm Biogal chromatographic test system (Israel). Statistical processing of the material was carried out in the Microsoft Excel 2010 program. Studies were carried out with the consent of animal owners and in accordance with the European Convention for the Protection of Vertebral Animals used for experimental and other scientific purposes (Strasbourg, 1986).

Results. As a result of the conducted studies, it was found that in the Voronezh oblast, the average infection of domestic dogs (Canis familiaris) with dirofilariasis is 14.14 ± 0.31 %. The indicator depends on the conditions of keeping animals and makes 27.15 % in stray dogs, 25.26 % – in service dogs and 10.54 % – in apartment dogs. In service dogs, the species D. repens occurs in 52.39 % of cases, D. immitis – in 42.95 %, mixtinvasia – in 4.80 % of cases. In stray dogs, the species D. repens prevails (80.10 %). The second type of D. immitis was established in 10.0 % of cases. At the same time, both types were also established in 10.0 % of cases. The maximum number of cases of dirofilariasis occurs in urban dogs (65.87 %), which is due to the high density of their population and close contact with the vector of transmission in urbanized areas. The seasonal dynamics of infestation is determined by the year-round detection of cases with a peak in October (46.77 %). The number of cases of dirofilariasis increases with age, in dogs from one to six years old it reaches maximum of 63.26 %. There is an epidemiological risk of dirofilariasis in the Voronezh oblast. This is due to the existence and active functioning of synanthropic and natural foci of invasion on the territory of the Voronezh oblast.
Retrospective of International Serological Studies on the Formation and Dynamics of the Humoral Immune Response to SARS-CoV-2: from 2020 to 2021
Authors: Novikova E. A. , Petrova A. G. , Moskaleva E. V. , Vanyarkinа A. S. , Rychkova L. V.
Published: June 2021

Last year the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has started. The new coronavirus is highly contagious and causes severe complications. The mechanisms of humoral immunity and kinetics of SARS-CoV-2 specific antibodies in a population are not well understood. Therefore, we aimed to summarize and analyze numerous global and Russian serological studies for understanding dynamics of the SARSCoV-2 humoral immune response and getting an accurate picture of the seroprevalence to SARS-CoV-2 in the world population. The PubMed and e-library databases were searched from February 2020 to March 2021 using terms “SARSCoV-2”, “antibodies”, “humoral immunity”. At the beginning of the pandemic first studies were cross-sectional by design and were responsible for determination of the seropositivity and for understanding the fundamental humoral immunity parameters of SARS-CoV-2. Since then, longitudinal seroepidemiological studies have been studying antibody kinetics. Seroconversion time for IgM, IgG antibodies varies, but most researchers report the seroconversion of IgM from the 1st to 14th days after the onset of clinical manifestations, and the seroconversion for IgG is around the 14th day with a concentration peak by the 21st day. Regarding seroprevalence we may say about low herd immunity at the COVID-19 pandemic. Thus, global seroprevalence is about 10 %, and more than 20 % for regions with high incidence and among healthcare workers. Seroprevalence studies have to be continued for more accurate monitoring of long-term humoral immunity to SARS-CoV-2, because the majority of the world’s population is still susceptible to SARS-CoV-2 infection.
Risk Factors of Thrombotic Complications and Antithrombotic Therapy in Paediatric Cardiosurgical Patients
Authors: Karakhalis N. B. , Karakhalis M. N.
Published: June 2021

The development of cardiosurgical care for paediatric and neonatal patients is undergoing the rapid growth. Complex, multi-stage reconstructive operations and the use of invasive monitoring are associated with high risk of venous and arterial thrombosis.

The cardiac surgery patient is inherently unique, since it requires controlled anticoagulation during cardiopulmonary bypass. Moreover, the most cardiovascular pediatric patients require antithrombotic measures over the perioperative period. In addition to medication support with the use of various groups of antithrombotic agents, vascular access management is justified in order to minimize the risk of thromboembolic complications, which can affect both the functional status, and common and inter-stage mortality.

The purpose of this review was to systematize the available data on risk factors contributing to the development of thrombotic complications in patients with congenital heart disease.

An information search was carried out using Internet resources (PubMed, Web of Science, eLibrary.ru); literature sources for period 2015–2020 were analysed. As a result of the analysis of the literature data age-dependent features of the haemostatic system, and associated with the defect pathophysiology, and undergone reconstructive interventions were described. The issues of pathophysiology of univentricular heart defects and risk factors associated with thrombosis were also covered.

Moreover, aspects of intraoperative anti-thrombotic support are discussed, as well as measures to prevent thromboembolic complications in this population.

Coordinated actions of haematologists, cardiologists, anaesthesiologists, intensivists, and cardiac surgeons will allow achieving a fine balance between risks of bleeding and thrombosis in the population of paediatric patients undergoing cardiovascular surgery.
František Dvorník, Velehrad Unionism and Church Unity
Authors: Ambros Pavel
Published: June 2021

This paper brings a so far neglected aspect of Francis Dvornik’s work to the fore, namely the influence of the Velehrad unionistic movement on the scientific and personal formation of Dvornik at the beginning of his scientific career on the one hand, which was on the other hand connected with the increasing Dvornik’s influence on the Velehrad unionistic movement. The reciprocal influence is documented on the gradual transformation of the period correlative unionism (on the background of the modernistic tension in the catholic theology) and by strengthening its protoecumenical tendencies towards the clear ecumenical program formulated by Dvornik himself.