bluuebunny/crossref_metadata_2025 huggingface dataset:
Difusi Teknologi Lubang Resapan Biopori di Musim Penghujan untuk Antisipasi Kelangkaan Air Sumur di Musim Kemarau
Authors: Firdaus Feris
Published: March 2024

Curah bujan yang sudah mulai tinggi menyebabkan terjadinya genangan air hujan di kawasan Komplek Masjid Al-Muhajirin, Tiyasan, Kelurahan Condongcatur, Kecamatan Depok, Sleman, D.I.Yogyakarta. Selain itu, genangan air yang terjadi saat hujan di kawasan Komplek Masjid Al-Muhajirin tersebut dipicu oleh maraknya program pengecoran jalan-jalan perkampungan dan ruas-ruas halaman rumah warga yang juga dicor beton dan paving block dalam beberapa tahun terakhir yang tidak didukung dengan drainase yang memadahi. Hasil kegiatan pengabdian masyarakat yang dilakukan di lokasi tersebut menunjukkan bahwa masyarakat sangat antusias dalam difusi teknologi lubang resapan biopori tersebut. Kegiatan pengabdian masyarakat ini dimulai dengan tahapan pelatihan di serambi masjid yang diikuti oleh takmir masjid dan jama’ah masjid yang tinggal di sekitar kawasan masjid. Materi yang disampaikan berupa konsep teknis difusi teknologi lubang resapan biopori berikut peralatan dan bahan yang diperlukan yakni alat bor tanah secara manual berbentuk T dengan ukuran panjang 1 m dan pipa PVC dengan ukuran diameter 4 inch beserta penutupnya yang sudah dilubangi menggunakan alat solder listrik. Tahapan berikutnya adalah praktik pembuatan lubang resapan biopori menggunakan alat adan bahan tersebut yang dilakukan secara pasrtisipatori yakni berdasarkan hasil pelatihan lantas masyarakat dapat mengimplementasikan pengetahuannya untuk membuat lubang resapan biopori yang didampingi pengabdi secara langsung. Pada tahapan praktik ini dihasilkan produk percontohan lubang resapan biopori dengan kedalaman 50 cm sebanyak 2 lubang resapan lengkap dengan 2 pipa PVC yang sudah dilubangi beserta tutupnya yang sudah siap meresapkan air hujan yang turun kemudian.

Kata Kunci: difusi, lubang resapan, biopori, air hujan, air sumur.
Optimalisasi Manajemen Persediaan Obat dan Bahan Medis Habis Pakai di RSUD Sleman
Authors: Mahmudi Mahmudi , Nurhidayat Syarif , Najamuddin Yunan
Published: March 2024

RSUD Sleman sebagai Badan Layanan Umum Daerah (BLUD) berfungsi memberikan pelayanan kesehatan kepada masyarakat tanpa mengutamakan mencari keuntungan. RSUD Sleman dituntut dapat memberikan pelayanan kesehatan yang berkualitas dengan harga yang terjangkau oleh masyarakat. Untuk itu RSUD Sleman harus mampu mengoptimalkan pendapatan dan melakukan efisiensi biaya. Dari sisi optimalisasi pendapatan, RSUD Sleman perlu melakukan perubahan tarif layanan, sedangkan dari sisi efisiensi biaya, RSUD Sleman perlu melakukan perbaikan manajemen persediaan obat dan bahan medis habis pakai. Saat ini, manajemen persediaan obat di RSUD Sleman masih memiliki beberapa kelemahan. Kelemahan tersebut antara lain terkait dengan pengadaan obat dilakukan berdasarkan permintaan masing-masing dokter (doctor-centric), beberapa pencatatan persediaan masih dilakukan secara manual, belum ada sistem informasi manajemen persediaan obat dan bahan medis habis pakai yang terintegrasi. Selain itu terdapat keterbatasan kapasitas gudang obat di RSUD Sleman. Program pengabdian ini dilakukan untuk membantu RSUD Sleman memperbaiki manajemen persediaan obat dan bahan medis habis pakai melalui perbaikan tata kelola sediaan medis dengan pendekatan management-centric. Metode yang digunakan dalam pengabdian ini adalah focus group discussion (FGD), wawancara, observasi, dan analisis dokumen. Luaran pengabdian ini adalah kajian manajemen persediaan obat dan bahan medis habis pakai di RSUD Sleman yang berisi analisis masalah dan rekomendasi perbaikan.
Implementasi Budaya Kerja 5S (Seiri, Seiton, Seiso, Seiketsu Dan Shitsuke) Di Emping Melinjo Ibu Sukati
Authors: Marfuah Hasti Hasanati , Hapsari Yaning Tri , Kurniawanti
Published: March 2024

Emping Melinjo Ibu Sukati merupakan salah satu UKM yang memproduksi emping di Tegalkenongo, Tirtonirmolo, Kasihan, Bantul. Proses produksi emping dilakukan di lantai produksi yang tidak rapi, peralatan produksi yang digunakan cenderung berserakan dimana-mana, tempat penjemuran tidak tertata rapi. Penataan peralatan kerja yang tidak tertata rapi menyebabkan para pekerja akan membutuhkan waktu lebih lama dalam mengambil peralatan produksi yang digunakan serta mempengaruhi tingkat produktivitas para pekerjanya. Tujuan dari pengabdian ini yaitu untuk memberikan pemahaman dan mendampingi dalam penerapan konsep 5S kepada mitra sehingga proses produksi lebih teratur dan rapi. Solusi untuk mengatasi masalah yang ada pada mitra adalah dengan menggunakan metode sosialisasi dan pendampingan penerapan budaya kerja 5S. Istilah 5S berasal dari bahasa Jepang yang dikenal sebagai singkatan dari: Seiri (Pemilahan), Seiton (Penataan), Seiso (Pembersihan), Seiketsu (Perawatan) dan Shitsuke (Pembiasaan). Rata-rata hasil evaluasi pelaksanaan pengabdian ini adalah 79,67% sehingga dapat dikatakan pengabdian ini cukup memberikan pemahaman bagi mitra dan mitra mampu menerapkan dalam pekerjaannya. Penerapan 5S membuat proses produksi berjalan lebih teratur dan rapi serta emping yang dihasilkan lebih terjaga kebersihannya.
Pendampingan Pengelolaan Media Sosial Bagi Pelaku Usaha UMKM Tanaman Hias Bonsai
Authors: Johansyach Muhammad Wildan , Abadi Totok Wahyu , Febriana Poppy
Published: March 2024

Program Abdimas merupakan upaya penyelesaian masalah yang berkaitan dengan pemilik usaha UMKM Aksara Bonsai di Gempol, Pasuruan. Permasalahanya dimana pelaku usaha ini kurang paham dalam pengelolaan media sosial. Maka dari itu, media sosial penting bagi pihak pelaku usaha dalam pengenalan produk secara efisien dan memasarkan di media sosial yang sebelumnya hanya pada pendeketan konvensional. Adapun tahapan pelaksanaan program tersebut yaitu observasi dan wawancara, perencanaan ide, proses kegiatan, pendampingan dan evaluasi kegiatan. Kegiatan dilaksanakan dalam waktu 2 (dua) minggu 2 kali yakni dari Minggu, 18 dan 25 Juni 2023 pada pukul 09.00 – 13.00 WIB di stand aksara bonsai Gempol, Pasuruan. Hasil dari kegiatan yakni pelaku usaha UMKM telah memahami pengelolaan media sebagai wadah untuk berjualan/memasarkan produk, penataan lapak penjualan, dan cara membuat logo sebagai identitas UMKM.
Application of Solar-Based Light Lumen to Papuyu Fish Farmers in Penggalaman Village, West Martapura
Authors: Kartini Dwi , Nugrahadi Dodon Turianto , Ramadhani Rahmat
Published: March 2024

Desa Penggalaman, Martapura Barat, Kabupaten Banjar, Kalimantan Selatan merupakan salah satu wilayah pengembangan perikanan ikan papuyu. Lokasi desa sangat strategis yang berada di sepanjang aliran irigasi Desa Penggalaman dan memiliki potensi yang sangat cukup dalam usaha perikanan bagi warga pembudidaya ikan. Warga Desa telah melakukan kegiatan pembudidayaan bibit ikan papuyu yang memiliki kolam untuk pembuahan buatan ikan papuyu, kolam penetasan telur ikan papuyu dan kolam pembesaran tetapi belum menerapkan pencahayaan dalam proses kegiatan budidaya ikan. Hal ini disebabkan karena membutuhkan energi listrik yang cukup banyak dan mengeluarkan biaya yang besar untuk kegiatan tersebut. Solusi kelistrikan yang ditawarkan ialah penggunaan peralatan listrik berbasis tenaga surya. Alat ini dilengkapi dengan lampu lumens kuning dan putih, controller, baterai, aerator dan panel surya serta sistem kontrol otomatis. Penerapan lumen cahaya lampu berbasis tenaga surya akan memberikan solusi teknologi pada pencahayaan kolam bibit dan pembesaran ikan papuyu bagi pembudidaya ikan papuyu Desa Penggalaman. Pencahayaan lumens warna kuning dan putih, selain memberikan penerangan di malam hari dapat mengurangi serangan predator malam. Hasil dari penerapan teknologi ini yaitu terpenuhinya penerapan cahaya lumens tenaga surya pada pembibitan ikan papuyu dan meningkatkan pencahayaan bibit dan pembesaran ikan papuyu kurang lebih 80%, serta mengurangi serangan predator malam hingga 70%.
Studies on airborne microbiota in Mexico, a review
Authors: Álvarez-Rivera Óscar Omar , Estrada-Medina Héctor , Monserrat Ferrer Miriam , O’connor-Sánchez Aileen
Published: March 2024

Airborne microbiota has garnered increasing interest in recent decades, not only because of its role as carrier of pathogenic microorganisms and its involvement in the deterioration of man-made objects, buildings, and food but also because of its participation in atmospheric processes and its content of microorganisms, important for biogeochemical cycles in different ecosystems. In order to understand and comprehensively analyze existing studies on airborne microbiota in Mexico, a systematic review was conducted utilizing Web of Science and Google Scholar as search tools. The information found in the 35 identified publications was systematically organized, including title, study location, sampling method, laboratory approach, identification method, and organisms found. This information was then ordered into three sections: bibliometric analysis, employed methodologies, and main findings. Through this work, it was revealed that the studies were carried out in 14 out of the 32 states of Mexico, with Mexico City standing out with 17 articles. Three methodological approaches were identified: microbial cultures (77% of the studies), microscopy (11.5%), and metagenomics (11.5%). The studies predominantly focused on state capitals or densely populated cities, making the identification of potentially pathogenic organisms from humans, animals, and plants, of particular interest. This comprehensive review lays the foundation for proposing compelling avenues of future research, aimed at advancing our comprehension of airborne microbiota in Mexico.
Analysis of Intensity Limits for Light Emitting Diodes Used in Toys and Consequences for Children's Visual Health
Authors: Martinsons Christophe , Enouf Olivier , Behar-Cohen Francine , Torriglia Alicia , Viénot Françoise , Attia Dina
Published: March 2024

The analysis of the current safety standards for electric toys showed that the normative intensity limits for visible light emitted by LEDs integrated in toys are overestimated. These limits were originally set in a scientific article published in 2012 that was adapted into the international safety standard published in 2017, and into the subsequent European and national standards, all published in 2020. The overestimation of the intensity limits results from several errors made in the original article. Accordingly, the current normative intensity limits for visible light used in toys do not protect the children’s eyes against adverse effects of exposure to high intensity LEDs which may compromise their visual health. Updating the safety standards for electric toys using a method based on robust scientific data is recommended to protect children's visual health and ensure their long-term well-being.
Topic Modelling of Management Research Assertions to Develop Insights on the Role of Artificial Intelligence in Enhancing the Value Propositions of New Companies
Authors: Tanev Stoyan , Keen Christian , Bailetti Tony , Hudson David
Published: March 2024

The article suggests a Value Proposition (VP) framework that enables the analysis of the beneficial impact of Artificial Intelligence (AI) resources and capabilities on specific VP development activities. To develop such a framework, we examined existing management research publications to identify and extract assertions that could be used as a source of actionable insights for new growth-oriented companies. The extracted assertions were assembled into a corpus of texts that were subjected to topic modelling analysis – a machine learning approach to natural language processing that is used to identify latent themes in large corpora of text documents. The topic modeling resulted in the identification of seven topics. Each topic is defined by a set of most frequent words co-occurring in a distinctive subset of texts that could be interpreted in terms of activities constituting the core elements of the VP framework. We then examined each activity in terms of its potential to be enhanced by employing AI resources and capabilities. The interpretation of the topic modeling results led to the identification of seven topics: 1) Value created; 2) Stakeholder value propositions; 3) Foreign market entry; 4) Customer base; 5) Continuous improvement; 6) cross-border operations; and 7) Company image. The uniqueness of the adopted topic modeling approach consists in the quality of the assertions and the interpretation of the seven topics as an activity framework, i.e. in its capacity to generate actionable insights for practitioners. The additional analysis suggests that there is a potential for AI to enhance emerging the four core elements of the VP framework: Value created, Stakeholder value propositions, Foreign market entry, and Customer base. More importantly, we found that the greatest number of assertions related to activities that could be enhanced by AI are part of the Customer base topic, i.e., the topic that is most directly related to the growth potential of the companies. In addition, the VP framework suggests that a company’s customer base growth is continuously enhanced through a positive loop enabled by activities focused on the Continuous improvement of the activities and the amount of Value created, the alignment of Stakeholder value propositions, and companies’ Foreign market entry. Thus, Foreign market entry appears as a factor that helps in understanding the beneficial impact of AI on the VP development of new growth-oriented companies.
Preventing Functional Decline with Age: Biomarkers and Best Practices
Authors: Halma Matthew , Marik Paul
Published: March 2024

The aging populations observed across numerous countries worldwide necessitate a thorough exploration of interventions aimed at promoting healthy aging. As individuals age, they undergo significant physiological changes that impact their functional capacity and often necessitate increased reliance on external support systems. Enhancing the autonomy and well-being of elderly individuals emerges as a critical imperative, serving not only individual interests but also broader societal goals. This review investigates various interventions designed to optimize the health and independence of aging populations, offering insights into effective strategies for promoting healthy aging and mitigating the societal burdens associated with an aging demographic.
Predicting and Analyzing Rainfall Patterns in Ethiopia Using Linear Regression Modeling
Authors: Melesse Moges Tsegaw , Delele Gezahegn Mulusew
Published: March 2024

With the use of linear regression modeling, this study sought to forecast and analyze rainfall patterns in Ethiopia. The dataset included historical rainfall data as well as pertinent independent variables. The R-squared score and mean squared error (MSE) were used to assess the effectiveness of the linear regression model. The results showed that the model's ability to forecast and analyze rainfall patterns was not very good. Only around 5.3% of the variance in rainfall could be explained by the chosen independent variables, according to the R-squared score of 0.053. This low number indicated that there was little correlation between the selected variables and rainfall, and that a sizable percentage of the variation in the dependent variable was not captured by the model. The model's accuracy in forecasting rainfall was shown to be quite low by the MSE error, with significant squared discrepancies between the expected and actual amounts. These results support the notion that the linear regression model as it is now designed is not appropriate for studying or forecasting Ethiopia's rainfall patterns. Alternative modeling approaches, the inclusion of other pertinent factors, and the assurance of the availability of high-quality data that faithfully captures the intricate dynamics of rainfall in the area all require more investigation.
Production of Polyhydroxyalkanotes by an Extreme Halophilic Bacterium Halomonas gomseomensis Using Different Carbon Sources
Authors: Tejo-Valencia Radamés , Cervantes-Uc José Manuel , Ramírez-Benitez Efraín , Lizama-Uc Gabriel , Fortis-Hernández Manuel , Rueda-Puente Edgar Omar
Published: March 2024

Polyhydroxyalkanoates (PHAs) are natural polyesters consisting of various chains of hydroxyalkanoates (HAs) produced by microorganisms; this polyestres has attention due environmentally friendly compounds from renewable sources as a substitute to conventional petroleum-based plastics. The objective of this study consisted in evaluating the Genotypic characterization and production of polimer of a halobacterium isolated from hypersaline ponds located at Las Coloradas (Yucatan, Mexico). Characterization of polymer produced by this strain was also performed. We concluded that, the analyzes obtained from this work demonstrated that the JCCOL25.2 strain has a 99% similarity with Halomonas gomseomensis, and is capable of using different carbon sources to synthesize PHAs. The physicochemical analyzes allowed the identification of the biopolymer produced and classifying it as polyhydroxybutyrate (PHB), because the characteristics of this biopolymer have been reported for similar polymers. PHB has various applications in the pharmaceutical, medical, food and agronomy areas. Likewise, PHB has interesting properties for use in food packaging, due to its characteristics such as biodegradability, optical activity and good barrier properties. Finally, the significance and impact of our study, there is only one study published on the biosynthesis of PHA’s by H. gomseomensis strains, although the characterization of the obtained polymer was not report.
Precision Medicine – Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care
Authors: Evans William , Meslin Eric M , Kai Joe , Qureshi Nadeem
Published: March 2024

Precision medicine (PM), also termed stratified, individualised, targeted or personalised medicine, embraces a rapidly expanding area of research, knowledge, and practice. It brings together two emerging health technologies to deliver better individualised care: the many “-omics” arising from increased capacity to understand the human genome; and “big data” and data analytics including Artificial Intelligence (AI). PM has the potential to transform an individual’s health, moving from population-based disease prevention to more personalised management. There is however a tension between the two, with a real risk that this will exacerbate health inequalities and divert funds and attention from basic healthcare requirements leading to worse health outcomes for many. All areas of medicine should consider how this will affect their practice, with PM now strongly encouraged and supported by government initiatives and research funding. In this review we discuss examples of PM in current practice and its emerging applications in primary care, such as clinical prediction tools that incorporate genomic markers and pharmacogenomic testing. We look towards potential future applications and consider some key questions for PM including evidence of real-world impact, its affordability, the risk of exacerbating health inequalities, and the computational and storage challenges of applying PM technologies at scale.
The Impact of Soil and Water Conservation Measures on Base Flow Modification: Evidence from Northeast Highland of Ethiopia.
Authors: Mihidin Mohammed Seid , Ayana Mekonen , Biru Zelalem , Alamerew Tenna , Desta Gizaw
Published: March 2024

Abstract: Due to sever land degradation throughout Ethiopia, the government has been implementing massive soil and water conservation works at the watershed scale since 2010 to conserve soil and water resources. However, most of the rivers in Ethiopia carry huge amount of sediment in the rainy season and streams dried up in the dry period. Planned research was conducted on two paired micro-catchments of Mt.Yewel with the main objective of evaluating the impact of soil and water conservation measures on base flow modification. Stream flow and rainfall data were collected from 22/11/2020 to 8/11/2022 on both micro-catchments at their outlets and center respectively. Base flow separation was done using Sp. Hydro base flow separation tool and SPSS Ver.21 statistical software was employed for data analysis. Flow duration curve (FDC) for both watersheds were developed. The FDC indicated that the base flow from treated micro-catchment is higher and sustained in the dry season while it is low and un-sustained in untreated micro-catchment. From statistical analysis, there is a significant difference in base flow enhancement between the treated and untreated micro-catchment (P<0.001). Hence, catchment treatment contributed to improve groundwater recharge and sustain base flow in the dry season by reducing surface runoff during rainy season.
Elevated NET, Calprotectin and Neopterin Levels Discriminate between Disease Activity of COVID-19 as Evidenced by Need of Hospitalization for Patients in Northern Italy
Authors: Hetland Geir , Fagerhol Magne Kristoffer , Mirlashari Mohammad Reza , Nissen-Meyer Lise Sofie Haug , Croci Stefania , Lonati Paola Adele , Bonacini Martina , Salvarani Carlo , Marvisi Chiara , Bodio Caterina , Muratore Francesco , Borghi Maria Orietta , Meroni Pier Luigi
Published: March 2024

Coronavirus disease 2019 (COVID-19) displays clinical heterogeneity, but little information is available for patients with mild or very early disease. We aimed to characterize biomarkers that are useful in discriminating the hospitalization risk in a COVID-19 cohort from Northern Italy during the first pandemic wave.
We enrolled and followed for four weeks 76 symptomatic SARS-CoV-2 positive patients and age/sex-matched healthy controls. Patients with mild disease were discharged (n.42), and the remaining were hospitalized (n.34). Blood was collected before any anti-inflammatory/immunosuppressive therapy and assessed for soluble C5b-9/C5a, H3-neutrophil extracellular traps (NET), calprotectin, DNase plasma levels by ELISA, and a panel of pro-inflammatory cytokines by ELLA.
Calprotectin and NET levels discriminate between hospitalized and non-hospitalized patients, while DNase negatively correlates with NET levels; there are positive correlations between calprotectin and both NET and neopterin levels. Neopterin levels increase in patients at the beginning of the disease and more in hospitalized than non-hospitalized ones. C5a and sC5b-9, and other acute phase proteins correlate with neopterin, calprotectin, and DNase. Both NET and neopterin levels negatively correlate with platelet count.
We show that calprotectin, NET, and neopterin are important proinflammatory parameters potentially useful in discriminating between COVID-19 patients at risk for hospitalization.
Oral Antiviral Defense: Saliva- and Beverage-Like Hypotonicity Dynamically Regulate Formation of Membraneless Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial Cells
Authors: Sehgal Pravin. B , Yuan Huijuan , Centone Anthony , DiSenso-Browne Susan V
Published: March 2024

The oral mucosa represents a defense between the external environment and the rest of the body and encompasses several antimicrobial and antiviral mechanisms. Oral mucosal cells are constantly bathed in hypotonic saliva (normally one-third tonicity compared to plasma) and are repeatedly exposed to environmental stresses of tonicity, temperature and pH by the drinks we imbibe (e.g. hypotonic: water, tea, coffee; hypertonic: assorted fruit juices, red wines), as well as of diverse microbial and viral flora. In the mouth, the broad-spectrum antiviral mediator MxA (a dynamin-family large GTPase) is constitutively expressed in healthy periodontal tissues, and also induced by Type III interferons (e.g. IFN-λ1). Endogenously induced human MxA and exogenously expressed human GFP-MxA formed membraneless biomolecular condensates in the cytoplasm of oral carcinoma cells (OECM1 cell line). These condensates likely represent storage granules in equilibrium with antivirally active dispersed MxA. Remarkably, cytoplasmic MxA condensates were exquisitely sensitive sensors of hypotonicity – the condensates in oral epithelium disassembled within 1-2 min of exposure of cells to saliva-like one-third hypotonicity, and spontaneously reassembled in the next 4-7 min. OECM1 cells preloaded with calcein-AM (a reporter of cytosolic “macromolecular crowding”) confirmed unquenching and then requenching of calcein fluorescence during this process. Hypertonicity had little effect on MxA condensates. The spontaneous reassembly of GFP-MxA condensates in oral epithelial cells even under continuous saliva-like hypotonicity was slowed by the protein phosphatase inhibitor cyclosporin A (CsA) and by the K-channel blocker tetraethylammonium chloride (TEA) suggestive of the involvement of the volume-sensitive WNK kinase-protein phosphatase (PTP)-K-Cl cotransporter (KCC) pathway in the regulated volume decrease (RVD) during condensate reassembly in oral cells. Thus, physiologically, hypotonic drinks (water, tea, coffee) trigger a rapid deployment of antiviral MxA throughout the cytoplasm of oral epithelial cells, with subsequent salvage of MxA back into storage granules/condensates.
Design and Performance Analysis of a Novel Hollow Core-Based Photonic Crystal Fiber for Edible Oil Sensing in the
Terahertz (THz) Regime
Authors: Ferdous Jannatun , Siddik Md. Abubakar , Haque Dr. Md. Dulal , Hossain Md. Selim , Rahman Mahafujur
Published: March 2024

This work proposes a hollow-core photonic crystal fiber-based edible oil sensor in the terahertz (THz) range (e.g., 1.0THz ≤ f ≤ 3.0THz) and different sensing characteristics are numerically analyzed. The suggested sensor’s performance was assessed by means of COMSOL Multiphysics, a commercial program that uses the finite element approach. The computational results indicate that the relative sensitivity is 85.591%, 84.648%, 82.625%, 82.683%, and 79.161%, respectively, at f = 2.2 THz, for several types of sunflower oil, mustard oil, coconut oil, olive oil and palm oil; and the corresponding effective areas are 7.22×10-8 um2, 7.09×10-8 um2, 6.83×10-8 um2,7.09×10-8 um2, 6.5231 ×10-8 um2. In addition, the effective material loss for sunflower oil, muster oil, coconut oil, olive oil, and palm oil has been found to be 0.02561 cm-1, 0.027054 cm-1, 0.030322 cm-1, 0.028854 cm-1 ,0.035427cm-1 respectively. Moreover, the proposed sensor also has low confinement loss are 1.55×10-8 dB/m, 1.63×10-8 dB/m, 1.31×10-8 dB/m, 1.99×10-8 dB/m, 4.0345×10-8 dB/m.This proposed sensor can be fabricated using extrusion and 3D-printing technologies, and due to its augmented detecting capabilities, it can be a vital part of oil sensing devices implemented in real life such as industry fields.
Comparative Effectiveness of Supervised and Home-based Rehabilitation after Anterior Cruciate Ligament Reconstruction in Competitive Athletes
Authors: Syed Rehan Iftikhar Bukhari , Hangody Laszlo Rudolf , Frischmann Gergely , Kós Petra , Kopper Bence , István Berkes
Published: March 2024

Background: After the increasingly common anterior cruciate ligament reconstruction (ACLR) procedure in competitive athletes, rehabilitation is crucial for facilitating a timely return to sports (RTS) and preventing re-injury. This pilot study investigates the biomechanical and psychological outcomes of postoperative rehabilitation in competitive athletes, comparing supervised rehabilita-tion (SVR) and home-based rehabilitation (HBR). Methods: After ACLR, 60 (out of 74 screened) athletes were recruited and equally divided into 2 groups using non-probability convenience sam-pling: 30 HBR and 30 SVR (each group comprising 15 males and 15 females). Rehabilitation out-comes in respective groups were evaluated at 8 months using measures (Tegner-Activity-Scale [TAS], International Knee Documentation Committee subjective knee form [IKDC-SKF], ACL Return to Sport after Injury [ACL-RSI]) and objective parameters (isometric muscle strength, hamstring/quadriceps asymmetry). RTS was evaluated at 9 months; with ACL re-injury rates rec-orded approximately 6 months post-RTS. Results: Both groups exhibited decreased TAS scores (HBR: 8 to 6, SVR: 8 to 7), with the SVR group demonstrating superior post-operative IKDC-SKF scores (81.82 vs. 68.43) and lower ACL-RSI scores (49.46 vs. 55.25). Isometric and isokinetic mus-cle strength, along with asymmetry values, favored the SVR group 8 months post-ACLR (p
Tea Grounds as a Waste Biofiller for Natural Rubber
Authors: Juszkiewicz Aleksandra , Maciejewska Magdalena
Published: March 2024

The aim of this study was utilization of ground tea waste (GT) left after brewing the black tea as a biofiller of natural rubber (NR) composites. Ionic liquids (ILs), i.e., 1-ethyl-3-methylimidazolium lactate and 1-benzyl-3-methylimidazolium chloride, often used to extract phytochemicals from tea, were applied to improve the dispersibility of GT particles in elastomeric matrix. The influence of GT loading and ILs on curing characteristics, crosslink density, mechanical properties, thermal stability and resistance of NR composites to thermo-oxidative aging was investigated. The amount of GT did not significantly affect curing characteristics and crosslink density of NR composites, but had serious impact on tensile properties. Applying 10 phr of GT improved the tensile strength by 40% compared to unfilled NR. Further increasing in GT content worsened the tensile strength due to the agglomeration of biofiller in elastomer matrix. ILs significantly improved the dispersion of GT particles in elastomer and increased the crosslink density by 20% compared to the benchmark. Owing to the poor thermal stability of pure GT, it reduced the thermal stability of vulcanizates compared to unfilled NR. Most importantly, GT-filled vulcanizates showed improved resistance to thermo-oxidative aging, since the aging factor increased by 25% compared to the unfilled vulcanizate.
Application of Waste Tire in Construction: A Road Towards Sustainability and Circular Economy
Authors: Hassan M. Rokib , Rodrigue Denis
Published: March 2024

The global demand for rubber is on a steady rise, which is driven by the increasing production of automobiles and the growing need for industrial, medical, and household products. This surge in demand has led to a significant increase in rubber waste, posing a major global environmental challenge. End-of-life tire (ELT) is a primary source of rubber waste, which possesses significant environmental hazards due to its massive stockpiles. While landfilling is a low-cost and easy-to-implement solution, it is now largely prohibited due to environmental concerns. Recently, ELT rubber waste has garnered considerable attention for its potential applications in civil engineering and construction. These applications not only enhance sustainability but also foster a circular economy between ELT rubber waste and the civil engineering and construction sectors.
This review article concentrates on the recent research progress and challenges in the civil engineering applications of ELT rubber waste. It also discusses commercially available recycled rubber-based construction materials, their properties, testing standards, and certification. To the best of the authors' knowledge, this is the first time such a discussion on commercial products has been presented.
Ovarian Fibrothecoma in a Mare-Case Report
Authors: Tamulionytė-Skėrė Raimonda , Juodžiukynienė Nomeda , Rimkutė Paulina , Gruodytė Renata , Duliebaitė Iveta , Savickytė Akvilė
Published: March 2024

Ovarian tumors in mares are not common in comparison to other neoplasms and are divided into three categories: gonadal stromal tumors, coelomic epithelium surface tumors, and germinative cell tumors [12]. Some ovarian neo-plasms histologically show a mixture of multiple cell types in the same tumor, such as fibrothecoma, therefore the dif-ferentiation between fibroma and thecoma is often difficult [1]. According to World Health Organization, fibrothecoma is classified as sex cords stromal tumor (pure stromal tumor) [13]. Neoplasms, such as fibrothecoma have a very scarce morphology, clinical signs, ultrasonographic view and endocrine profile. To diagnose this type of tumor, a broad clini-cal examination is needed, but histopathology remains the most accurate. Herein, we report a case of incidentally found ovarian fibrothecoma during diagnostic laparotomy in 6-year-old KWPN mare which was presented to the clinic with colic symptoms. After unilateral ovariectomy, the altered right ovary, based on histopathological features was diag-nosed as fibrothecoma.
Autoimmune Hemolytic Anemias
Authors: Loriamini Melika , Cserti-Gazdewich Christine , Branch Donald R.
Published: March 2024

Autoimmune hemolytic anemias (AIHAs) are conditions whereby a person produces an antibody to their own red blood cells (RBCs). These conditions can be primary with unknown cause or secondary, associated with diseases or infections. There are seven different categories of AIHA, warm-antibody AIHA (wAIHA); cold-antibody AIHA that includes cold agglutinin syndrome (CAS) and cold agglutin disease (CAD); mixed AIHA, also called combined cold and warm AIHA; paroxysmal cold hemoglobinuria (PCH) also termed Donath-Lansteiner test-positive AIHA; direct antiglobulin test-negative AIHA (DAT-neg AIHA); drug-induced immune hemolytic anemia (DIIHA); and passenger lymphocyte syndrome. This review will discuss each of these AIHAs and provide information on diagnosis and treatment.
Quantum Entanglement Asymmetry and the Cosmic Matter-Antimatter Imbalance: A Theoretical and Observational Analysis
Authors: Neukart Florian
Published: March 2024

In this study, we investigate Quantum Entanglement Asymmetry (QEA) as a potential explanation for the matter-antimatter imbalance observed in the universe. By integrating quantum mechanics with cosmological phenomena, the study proposes a model in which quantum entanglement among particle-antiparticle pairs in the early universe leads to an asymmetry favoring matter. Through theoretical development and numerical simulations, we explore how this model predicts unique patterns in Cosmic Microwave Background (CMB) anisotropies and the distribution of matter, setting a foundation for empirical verification. The study aims to enhance the understanding of cosmological asymmetries and highlight the significance of quantum entanglement in the universe's evolution.
Green and efficient extraction of phenolic components from plants with supramolecular solvents: Experimental and theoretical studies
Authors: Xia Bo-hou , Yu Zhi-lu , Lu Yu-ai , Liu Shi-jun , Li Ya-mei , Xie Ming-xia , Lin Li-mei
Published: March 2024

Supramolecular solvent (SUPRAS) has received increasing interest as an innovative, efficient, and green solvent for the effective extraction and separation of bioactive compounds from natural resources. However, studies on the use of SUPRAS for the extraction of phenolic components from plants, which are highly valued in food products due to their excellent antioxidant capacity, are still lacking. The present study developed a green ultrasound-assisted and efficient SU-PRAS method to simultaneously determine three phenolic acids in Prunella vulgaris by high-performance liquid chromatography (HPLC) and the experimental parameters were optimized in detail. The efficiency and antioxidant properties of the phenolic compounds obtained by different extraction methods were also compared. Under the optimal conditions, the extraction efficiency of SUPRAS, prepared with octanoic acid reverse micelles dispersed in ethanol-water, was substantially higher than conventional organic reagents. Moreover, this SUPRAS method also showed more significant antioxidant capacities. The confocal laser scanning microscopy (CLSM) images presented the spherical droplet structure of SUPRAS (A well-defined circle), which coincided with the position of the fluorescence position of phenolic acids. The phenolic acids were encapsulated in the vesicles by the SUPRAS droplets, which indicated the efficient extraction capacities of SUPRAS for the target compounds. Finally, combined with the CLSM method, the mechanism of the proposed method was further clarified, and the superior extraction performance of SUPRAS was theoretically demonstrated through molecular dynamics simulations. In comparison with conventional methods, the higher extraction efficiency of SUPRAS can be illustrated by the larger solvent contact surface area, more types of hydrogen bonds between extractants and supramolecular solvents, and stronger and more stable interaction forces. The results of the theoretical studies are in rational agreement with the experimental outcome.
Exploring Dengue Dynamics: Multi-Scale Analysis of Spatio-Temporal Trends in Ibagué, Colombia
Authors: Otero Julian , Tabares Alejandra , Santos-Vega Mauricio
Published: March 2024

Our study examines how dengue incidence is associated with spatial (demographic and socioeconomic) alongside temporal (environmental) factors at multiple scales. We used the incidence of dengue in Ibagué, Colombia, from 2013 to 2018, to examine the associations with climate, socioeconomic and demographic factors from the census and satellite imagery at various levels of local spatial aggregation, including Manzanas, Secciones, Sectores, and Comunas. Our findings show a significant effect of spatial variables at finer levels of aggregation, showing varying degrees of correlation with dengue incidence. Temporal variables such as temperature and precipitation displayed consistent patterns across all spatial levels, with notable variations in Relative Risk (RR). Our study employs Geographically Weighted Regression (GWR) to identify relevant socioeconomic and demographic predictors. Then, these predictors were integrated into hierarchical models implemented in Integrated Nested Laplace Approximation (INLA) at each spatial level to assess spatiotemporal interactions. We comprehensively analyzed the three distinct models developed for each level: spatial, temporal, and spatiotemporal. A comparative evaluation of the models reveals that while higher aggregation levels often yield a better overall model fit, finer levels offer more detailed insights into the localized impacts of socioeconomic and demographic variables on dengue incidence. Our results underscore the importance of considering macro and micro-level factors in epidemiological modeling and highlight the potential for targeted public health interventions based on localized risk factor analysis. Notably, the intermediate level Secciones emerged as the most informative, balancing spatial heterogeneity and case distribution density, thereby providing a robust framework for understanding the spatial determinants of dengue.
Traditional Plant‐Derived Compounds Inhibit Cell Migration and Induce Novel Cytoskeletal Effects in Glioblastoma Cells
Authors: Thompson Evan , Prior Sally , Brüning-Richardson Anke
Published: March 2024

Glioblastomas (GBMs) are aggressive and invasive cancers of the brain, associated with high rates of tumor recurrence and poor patient outcomes despite initial treatment. Targeting cell migration is therefore of interest in highly invasive cancers such as GBMs, to prevent tumor dissemination and regrowth. One current aim of GBM research focusses on assessing anti-migratory properties of novel or repurposed inhibitors, including plant-based drugs which display anti-cancer properties. We investigated the potential anti-migratory activity of plant-based products with known cytotoxic effects in cancers, using a range of two-dimensional (2D) and three-dimensional (3D) migration and invasion assays as well as immunofluorescence microscopy to determine specific anti-migratory and phenotypic effects of three plant-derived compounds, Turmeric, Indigo and Magnolia bark, on established glioma cell lines. Migrastatic activity was observed in all three drugs, with Turmeric exerting the most inhibitory effect on GBM cell migration into scratches and from the spheroid edge at all timepoints investigated (p < 0.001). We also observed novel cytoskeletal phenotypes affecting actin and focal adhesion dynamics. By determining the migrastatic activity of Turmeric, Indigo and Magnolia on GBM cell migration, we demonstrate a potential role for Turmeric as a novel GBM anti-migratory therapeutic, in combination with the current standard of care, to prevent tumor recurrence and promote patient survival.
Organellar RNA Helicases as Key Tools in Plant Organellar RNA Splicing and Regulation of Gene Expression
Authors: Mizrahi Ron , Ostersetzer-Biran Oren
Published: March 2024

Mitochondria are semiautonomous organelles, which are pivotal for the energy metabolism of eukaryotic cells. These organelles contain their own genetic system (mtDNA, mitogenome) that encodes to some structural RNAs and organellar proteins. The biogenesis and function of mitochondria is tightly regulated by nuclear-encoded protein cofactors. The mtDNAs of land plants are characteristically large, with a complex mode of gene organization and expression, in particularly at the post-transcriptional level. To become functional, the primary organellar transcripts undergo extensive maturation steps, which include endo- and exo-nucleolytic cleavage, RNA-base editing, and both ‘cis’- and ‘trans’-splicing events. These essential processing steps rely on the activities of a large set of nuclear-encoded factors. Among these, the RNA helicases serve as key players in organellar (mt-)RNA metabolism. This review summarizes the important roles played by these factors in regulating the highly dynamic processes of transcription, RNA processing, and translation within the mitochondria of land plants. We further discuss recent advancements in understanding how dysregulation of mitochondrial RNA helicases affects the organellar gene expression, respiratory functions, and hence the growth, development and physiology of land plants.
Application of Polysaccharide‐Based Columns for the Separation of Racemic Mixtures Obtained Based on (R,S)‐2‐Octanol by Reversed‐Phase Chiral Liquid Chromatography
Authors: Urbańska Magdalena
Published: March 2024

The polysaccharide-based chiral stationary phase (CSP) columns for high-performance liquid chromatography (HPLC) were applied in the separation of liquid crystalline racemic mixtures obtained based on (R,S)-2-octanol and were found to be highly effective in recognizing isomers of minor structural differences. The mobile phase (MP), which consists of acetonitrile (ACN)/water (H2O) at different volume ratios, was used. All measurements were made at room temperature. The order of the elution was also determined. The chromatographic parameters such as resolution - (Rs), selectivity - (α), and the number of theoretical plates, i.e., column efficiency - (N), were determined. The polysaccharide-based CSP columns have unique advantages in separation technology, and this study has shown the potential usefulness of the CSP columns in separating liquid crystalline racemic mixtures belonging to the same homologous series.
Identification of Fatty Acids, Amides and Cinnamic Derivatives in Supercritical-CO2 Extracts of Cinnamomum tamala Leaves Using UPLC-Q-TOF-MSE Combined with Chemometrics
Authors: Lohani Hema , Kumar Arvind , Bidarakundi Vinod , Agrawal Lalit , Haider Syed Zafar , Chauhan Nirpendra Kumar
Published: March 2024

Cinnamomum tamala leaf (CTL), also known as tejpat and Indian bay leaf, is used all over the world for seasoning, flavouring, and medicinal purposes. Numerous researchers are interested in exploring the nutritional and medicinal benefits of CTL due to their potential as nutraceuticals. These characteristics could be explained by the presence of several essential bioactive substances and lipid derivatives. There are no reports available on this species about its metabolites profile. In this work, rapid screen and identify chemical compounds in supercritical (SC)-CO2 extracts of CTL by use of UPLC-Q-TOF-MSE with multivariate statistical analysis approach was established in both negative and positive mode. As a results, a total of 166 compounds, including 66 monocarboxylic fatty acids, 52 dicarboxylic fatty acids, 27 fatty acid amides, and 21 others were tentatively identified based on accurate mass, and the mass spectrometric fragmentation pattern, out of which 142 compounds are common and found in all five CTL extracts. They displayed robust [M+H]+ and/or [M-H]- ions in both low- and high-energy collision-induced dissociations (CIDs). Based on chemical profiling and chemometric analysis, CTL4 (300bar/55°C) extract was found significantly more potent in other CTL’s extracts. A new mono- and di-carboxylic fatty acids, fatty acid amides and other essential bioactive compounds were separated within 20 min runtime and identified in CTL for the first time. The combination of UPLC-Q-TOF-MSE and chemometric analysis is a powerful method to rapidly screen the metabolites profile for the quality control of C. tamala leaf.
Mangled Thumb Injury Reconstruction with the Use of Definitive External Fixation and the Masquelet Technique
Authors: Berkay Fehmi , Schneider Andrew , Minhas Arjun , Wimalawansa Sunishka
Published: March 2024

Case:

A 23-year-old right-hand dominant man presented with a high-velocity gunshot wound injury to the right thumb with severe soft-tissue damage, vascular injury, and large osseous defect of the right thumb metacarpal. The patient was successfully treated with metacarpophalangeal joint arthrodesis and metacarpal reconstruction using definitive external fixation, an intramedullary Kirschner wire, and use of the Masquelet bone grafting technique.

Conclusion:

The authors' treatment approach for a mangled thumb injury with definitive external fixation and utilization of the Masquelet technique resulted in restoration of a large osseous defect, avoidance of infection, and limited loss of mobility.
Bell Palsy and Parsonage-Turner Syndrome Following Pneumococcal Vaccination: A Case Report
Authors: Maez Devin A. , Pierce Carina S. , Richter Dustin L.
Published: March 2024

Parsonage-Turner syndrome (PTS), also known as brachial neuritis, is a rare self-limiting, idiopathic condition characterized by sudden onset upper extremity pain with associated weakness and muscle atrophy. There exists a growing association between the development of PTS and infection/vaccinations in recent years. No case of PTS has been documented following pneumococcal vaccination to date. Bell palsy (BP) is an idiopathic disease process involving acute-onset unilateral acute facial paralysis resulting from edema and inflammation of the seventh cranial nerve. The etiology of BP is also largely unknown, but infectious processes, including viral reactivation and adverse vaccination reactions, have recently been documented. Although both PTS and BP are uncommon on their own, it is extremely rare for the 2 conditions to occur simultaneously. This case report presents a unique case of PTS and BP developing following the administration of the pneumococcal 20-valent conjugate vaccine.