bluuebunny/crossref_metadata_2025 huggingface dataset:
Health Outcomes for Children in Haiti Since the 2010 Earthquake: A Systematic Review
Authors: Dube Annie , Moffatt Madeline , Davison Colleen , Bartels Susan
Published: December 2017

Background

Haiti remains the poorest country in the Americas and one of the poorest in the world. Children in Haiti face many health concerns, some of which were exacerbated by the 2010 earthquake. This systematic review summarizes published research conducted since the 2010 earthquake, focusing on health outcomes for children in Haiti, including physical, psychological, and socioeconomic well-being.

Methods

A literature search was conducted identifying articles published from January 2010 through May 2016 related to pediatric health outcomes in Haiti. Two reviewers screened articles independently. Included research articles described at least one physical health, psychological health, or socioeconomic outcome among children less than 18 years of age in Haiti since the January 2010 earthquake.

Results

Fifty-eight full-length research articles were reviewed, covering infectious diseases (non-cholera [N=12] and cholera [N=7]), nutrition (N=11), traumatic injuries (N=11), mental health (N=9), anemia (N=4), abuse and violence (N=5), and other topics (N=3). Many children were injured in the 2010 earthquake, and care of their injuries is described in the literature. Infectious diseases were a significant cause of morbidity and mortality among children following the earthquake, with cholera being one of the most important etiologies. The literature also revealed that large numbers of children in Haiti have significant symptoms of posttraumatic stress disorder (PTSD), peri-traumatic stress, depression, and anxiety, and that food insecurity and malnutrition continue to be important issues.

Conclusions

Future health programs in Haiti should focus on provision of clean water, sanitation, and other measures to prevent infectious diseases. Mental health programming and services for children also appear to be greatly needed, and food insecurity/malnutrition must be addressed if children are to lead healthy, productive lives. Given the burden of injury after the 2010 earthquake, further research on long-term disabilities among children in Haiti is needed.

DubeA,MoffattM,DavisonC,BartelsS.Health outcomes for children in Haiti since the 2010 earthquake: a systematic review.Prehosp Disaster Med.2018;33(1):77–88.
Sounding Riddims: King Tubby’s dub in the context of soundscape composition
Authors: Yoganathan Nimalan , Chapman Owen
Published: December 2017

A significant body of academic literature and music journalism has explored the historical trajectory of Jamaican dub music and its innovative use of audio recording technology. The present article seeks to demonstrate the similarities between the studio compositional methods of Jamaican dub innovator King Tubby and those of Canadian soundscape composers Barry Truax and Hildegard Westerkamp. Rather than attempting to identify aesthetic and stylistic similarities between Tubby’s dub music and soundscape composition, this article presents a comparative analysis of dub in relation to soundscape composition focusing on artistic articulations of contextual meaning and acoustic communication. Specifically, this work argues that Tubby’s compositional approach directly addresses the following conceptual themes common in soundscape composition: 1) referential composition and the invocation of past listening associations through sonic abstraction, 2) timbral play as a means of linking sound processing to acoustic communication, and 3) the evocation of real-world motion cues by way of ecologically informed sound-processing effects. Exploring the conceptual similarities between Tubby’s work and the established academic-affiliated genre of soundscape composition provides a new perspective on his work as reflecting a multifaceted musical approach that warrants further scholarly study.
Military Bands in the Romanian Principalities between 1821 and 1878
Authors: Gheorghiţă Nicolae
Published: December 2017

The abandonment in the early nineteenth century of the Ottoman military bands (mehterhâne and tabl-khāne) that had provided ceremonial music for the Romanian princes, and the establishment of Western-style military bands in the newly formed army, brought about a radical shift in the cultural paradigm that was to have an effect upon the entire spectrum of musical life in the capitals of the Romanian provinces of Wallachia and Moldavia. This change occurred at two levels: on the one hand, musicians and the repertory current in noble salons were imported from the West, and, on the other, a native ethnic element was activated in a series of works and orchestrations based on folk themes. The present study examines the emergence, development and organization of the modern military bands in the Principalities of Wallachia and Moldavia in the context of native musical practices and the transition of Romanian society from an oriental mentality to an outlook and behaviour specific to Western Europe, in the period from the nineteenth century to the War of Independence (1877).
Projection models for health expenses
Authors: Christiansen Marcus , Denuit Michel , Lucas Nathalie , Schmidt Jan-Philipp
Published: December 2017

This note proposes a practical way for modelling and projecting health insurance expenditures over short time horizons, based on observed historical data. The present study is motivated by a similar age structure generally observed for health insurance claim frequencies and yearly aggregate losses on the one hand and mortality on the other hand. As an application, the approach is illustrated for German historical inpatient costs provided by the Federal Financial Supervisory Authority. In particular, similarities and differences to mortality modelling are addressed.
The oldest representative of the family Austropanorpidae (Mecoptera) from the Lower Jurassic of Siberia
Authors: Krzemiński Wiesław , Soszyńska-Maj Agnieszka , Kopeć Katarzyna , Sukatsheva Irena D.
Published: December 2017

The family Austropanorpidae (Mecoptera) was described by Willmann in 1977 from the Eocene of Australia, based on one genus and species, Austropanorpa australis Riek, 1952. During a restudy of the collection of the Paleontological Institute, Russian Academy of Sciences in Moscow, a second and much older representative of this family was found. This specimen, described as Orthophlebia martynovae Sukatsheva, 1985 from Siberia (Russia), was considered until now to be a member of family Orthophlebiidae. We transfer this species to the Austropanorpidae, extending the age of this family back to the Early Jurassic. An updated diagnoses of the family Austropanorpidae and genus Austropanorpa are presented here.
Publisher Correction: Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials
Authors: Koo Bonkon , Koh Chin Su , Park Hae-Yong , Lee Hwan-Gon , Chang Jin Woo , Choi Seungjin , Shin Hyung-Cheul
Published: December 2017

A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
Prediction of aesthetic reconstruction effects in edentulous patients
Authors: Yuan Fusong , Cheng Cheng , Dai Ning , Sun Yuchun
Published: December 2017

The aim of the study is to establish a virtual prediction method to predict aesthetic reconstruction effects in edentulous patients. The facial soft tissue surface data before and after wearing complete dentures of ten edentulous patients were acquired with a facial Three-dimension scanner. Then, the two sets of scanned data were entered into the same coordinate system. Manual interaction was performed to extract the external boundary of the perioral appearance deformation area, and the proportional relationships of key facial anatomical features were measured. A virtual prediction software module was developed based on back-propagation neural networks and a Laplacian deformation algorithm. Virtual prediction of the aesthetic reconstruction effects in the overall appearance of the lower third of the face was performed in 10 edentulous patients. The mean accuracy of the virtual predictions was approximately 0.769 ± 0.205 mm, and there were statistically significant differences between the 10 patients (p < 0.05). The scope of the changes in facial appearance of edentulous patients was smaller than the scope of the lower third of the face. This method can achieve the virtual prediction of soft tissue appearance in the lower third of the face after wearing complete dentures to an extent.
Knockdown of long non-coding RNA H19 inhibits multiple myeloma cell growth via NF-κB pathway
Authors: Sun Yuanyuan , Pan Jing , Zhang Ning , Wei Wei , Yu Shanshan , Ai Limei
Published: December 2017

Long non-coding RNAs (lncRNAs) are implicated in the complex network of cancer including Multiple myeloma (MM) and play important roles in tumor development. lncH19 was significantly up-regulated in multiple cancer types, suggesting it is a potential oncogene. However, the exact functions and downstream mechanisms are largely unknown. This study aimed to investigate whether H19 participates in the cell growth of MM and elucidate the underlying mechanism. We found that H19 was abnormally overexpressed in MM cell lines and sorted CD138+ MM bone marrow tissues. H19 knockdown induced by shRNA transfection significantly inhibited proliferation, viability and colony formation in MM cells, as well as inactivated NF-κB pathway. Moreover, combination treatment of H19 knockdown and NF-κB suppression (induced by specific inhibitor PDTC) produced synergistically inhibitory effects. Bone marrow expression of H19 was positively associated with circulating IL-6 or IL-8 level in the same MM patients. And patients with high expression of H19 had a lower survival rate. Taken together, we confirmed the abnormal upregulation of a novel lncRNA, H19, in human MM. H19 was involved in MM cell growth. The linkage between H19 and NF-κB pathway may provide a novel interpretation for the mechanism of H19’s growth regulation in MM.
The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis
Authors: Ogata Kayoko , Tsumuraya Tomoyuki , Oka Kyoko , Shin Masashi , Okamoto Fujio , Kajiya Hiroshi , Katagiri Chiaki , Ozaki Masao , Matsushita Masayuki , Okabe Koji
Published: December 2017

Transient receptor potential melastatin-7 (TRPM7) is a bi-functional protein containing a kinase domain fused to an ion channel. TRPM7 is highly expressed in ameloblasts during tooth development. Here we show that TRPM7 kinase-inactive knock-in mutant mice (TRPM7 KR mice) exhibited small enamel volume with opaque white-colored incisors. The TRPM7 channel function of ameloblast-lineage cells from TRPM7 KR mice was normal. Interestingly, phosphorylation of intracellular molecules including Smad1/5/9, p38 and cAMP response element binding protein (CREB) was inhibited in ameloblasts from TRPM7 KR mice at the pre-secretory stage. An immunoprecipitation assay showed that CREB was bound to TRPM7, suggesting that direct phosphorylation of CREB by TRPM7 was inhibited in ameloblast-lineage cells from TRPM7 KR mice. These results indicate that the function of the TRPM7 kinase domain plays an important role in ameloblast differentiation, independent of TRPM7 channel activity, via phosphorylation of CREB.
Discovery of novel solid solution Ca3Si3−x
O3+x
N4−2x
: Eu2+ phosphors: structural evolution and photoluminescence tuning
Authors: Wang Baochen , Liu Yan-gai , Huang Zhaohui , Fang Minghao , Wu Xiaowen
Published: December 2017

Discovery of novel phosphors is one of the main issues for improving the color rendering index (CRI) and correlated color temperature (CCT) of white light-emitting diodes (w-LEDs). This study mainly presents a systematic research on the synthesis, crystal structure variation and photoluminescence tuning of novel (oxy)nitride solid solution Ca3Si3−x
O3+x
N4−2x
: Eu2+ phosphors. XRD refinements show that lattice distortion occurs when x value diverges the optimum one (x = 1). The lattice distortion causes a widening of emission spectrum and an increase of Stokes shift (ΔSS), which leads to a bigger thermal quenching. With decrease of x value, the emission spectrum shows an obvious red-shift from 505.2 to 540.8 nm, which is attributed to the crystal field splitting. The enhanced crystal field splitting also broadens the excitation spectrum, making it possible to serve as the phosphor for near ultraviolet (n-UV) LEDs. A 3-phosphor-conversion w-LED lamp was fabricated with the as-prepared phosphor, which exhibits high CRI (Ra = 85.29) and suitable CCT (4903.35 K). All these results indicate that the Ca3Si3−x
O3+x
N4−2x
: Eu2+ phosphor can serve as the green phosphor for n-UV w-LEDs, with a tunable spectrum by controlling the crystal structure and morphology.
Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy
Authors: Tang Shirong , Luo Zhong , Qiu Xiaowei , Zhang Yanke , Lu Xi , huang Hao , Xu Zhongxiang , Xu Zucai
Published: December 2017

Growth hormone releasing hormone (GHRH) has recently been shown to increase the level of γ-aminobutyric acid (GABA) and activate GABA receptors (GABARs) in the cerebral cortex. GABA is an inhibitory neurotransmitter that can inhibit seizures. Does GHRH enhance the inhibitory effect of GABA to prevent epilepsy by increasing the GABA level and activating GABARs? In this study, patients with epilepsy and C57/BL6 mice with epilepsy induced by kainic acid (KA) or pentylenetetrazol (PTZ) served as the research subjects. Western blots were used to observe the differences in GHRH expression between the normal group and the epilepsy group, immunofluorescence was performed to explore the localization of GHRH in the brain, and coimmunoprecipitation was used to observe the interaction between GHRH and GABARs. GHRH expression was significantly increased in both patients with temporal lobe epilepsy (TLE) and in two mouse models induced by KA or PTZ compared with that in the normal groups (P < 0.05 or P < 0.01). GHRH was expressed in neurons in both humans and mice. Additionally, GHRH co-localized with presynaptic and postsynaptic sites of inhibitory neurons. Coimmunoprecipitation confirmed that GHRH interacted with GABAAα1 and GABAAβ2 + 3. GHRH may play an important role in inhibiting seizures by activating GABAARs.
A curated mammography data set for use in computer-aided detection and diagnosis research
Authors: Lee Rebecca Sawyer , Gimenez Francisco , Hoogi Assaf , Miyake Kanae Kawai , Gorovoy Mia , Rubin Daniel L.
Published: December 2017

Published research results are difficult to replicate due to the lack of a standard evaluation data set in the area of decision support systems in mammography; most computer-aided diagnosis (CADx) and detection (CADe) algorithms for breast cancer in mammography are evaluated on private data sets or on unspecified subsets of public databases. This causes an inability to directly compare the performance of methods or to replicate prior results. We seek to resolve this substantial challenge by releasing an updated and standardized version of the Digital Database for Screening Mammography (DDSM) for evaluation of future CADx and CADe systems (sometimes referred to generally as CAD) research in mammography. Our data set, the CBIS-DDSM (Curated Breast Imaging Subset of DDSM), includes decompressed images, data selection and curation by trained mammographers, updated mass segmentation and bounding boxes, and pathologic diagnosis for training data, formatted similarly to modern computer vision data sets. The data set contains 753 calcification cases and 891 mass cases, providing a data-set size capable of analyzing decision support systems in mammography.
Take-off engine particle emission indices for in-service aircraft at Los Angeles International Airport
Authors: Moore Richard H. , Shook Michael A. , Ziemba Luke D. , DiGangi Joshua P. , Winstead Edward L. , Rauch Bastian , Jurkat Tina , Thornhill Kenneth L. , Crosbie Ewan C. , Robinson Claire , Shingler Taylor J. , Anderson Bruce E.
Published: December 2017

We present ground-based, advected aircraft engine emissions from flights taking off at Los Angeles International Airport. 275 discrete engine take-off plumes were observed on 18 and 25 May 2014 at a distance of 400 m downwind of the runway. CO2 measurements are used to convert the aerosol data into plume-average emissions indices that are suitable for modelling aircraft emissions. Total and non-volatile particle number EIs are of order 1016–1017 kg−1 and 1014–1016 kg−1, respectively. Black-carbon-equivalent particle mass EIs vary between 175–941 mg kg−1 (except for the GE GEnx engines at 46 mg kg−1). Aircraft tail numbers recorded for each take-off event are used to incorporate aircraft- and engine-specific parameters into the data set. Data acquisition and processing follow standard methods for quality assurance. A unique aspect of the data set is the mapping of aerosol concentration time series to integrated plume EIs, aircraft and engine specifications, and manufacturer-reported engine emissions certifications. The integrated data enable future studies seeking to understand and model aircraft emissions and their impact on air quality.
Colorimetric molecular diagnosis of the HIV gag gene using DNAzyme and a complementary DNA-extended primer
Authors: Kim Seong U. , Batule Bhagwan S. , Mun Hyoyoung , Byun Ju-Young , Shim Won-Bo , Kim Min-Gon
Published: December 2017

A simple, sensitive and selective colorimetric molecular diagnosis of HIV-I infections by horseradish peroxidase (HRP)-mimicking DNAzyme integrated PCR technique was demonstrated.
Correction: Tridentate tripodal sulfur ligand as a stable molecular surface anchor for the fabrication of oligonucleotide-gold based label-free biosensors
Authors: Deodhar Tejal J. , Yin Huancai , Chen Mingli , Lu Yihong , Xiong Daxi , Hu Jun Jack
Published: December 2017

Correction for ‘Tridentate tripodal sulfur ligand as a stable molecular surface anchor for the fabrication of oligonucleotide-gold based label-free biosensors’ by Huancai Yin et al., Anal. Methods, 2017, 9, 600–608.
An access to 1,3-azasiline-fused quinolinonesviaoxidative heteroannulation involving silyl C(sp3)–H functionalization
Authors: Wu Li-Jun , Yang Yuan , Song Ren-Jie , Yu Jiang-Xi , Li Jin-Heng , He De-Liang
Published: December 2017

A Mn-promoted intermolecular oxidative heteroannulation ofN-(2-cyanoaryl)-acrylamides with tertiary silanes toward 1,3-azasiline-fused quinolinones is presented.
Long-range behavior of the transition dipole moments of heteronuclear dimers XY (X, Y = Li, Na, K, Rb) based onab initiocalculations
Authors: Bormotova E. A. , Kozlov S. V. , Pazyuk E. A. , Stolyarov A. V.
Published: December 2017

The electronic transition dipole moments between the ground and excited states converging to the lowest three dissociation limits of heteronuclear dimers XY (X, Y = Li, Na, K, Rb) wereab initiocalculated and asymptotically analyzed at large internuclear distance.
Quantitative biosensor detection by chemically exchanging hyperpolarized 129Xe
Authors: Korchak S. , Riemer T. , Kilian W. , Mitschang L.
Published: December 2017

Quantitative modeling and evaluation of biosensor detection by hyperpolarized 129Xe chemical exchange saturation transfer (Hyper-CEST).
Investigation of the interaction of amyloid β peptide (11–42) oligomers with a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membrane using molecular dynamics simulation
Authors: Xiang Ning , Lyu Yuan , Zhu Xiao , Narsimhan Ganesan
Published: December 2017

The mechanism of pore formation in model neural cell membranes by β amyloid (Aβ) peptides was investigated using molecular dynamics simulation which indicated that Aβ oligomers of size equal or greater than 3 has a higher tendency for pore formation than monomers and that cholesterol tends to retard Aβ binding and insertion into the membrane.
Magnetic nickel ferrite nanoparticles as highly durable catalysts for catalytic transfer hydrogenation of bio-based aldehydes
Authors: He Jian , Yang Song , Riisager Anders
Published: December 2017

Commercial nickel ferrite (NiFe2O4) nanoparticles are efficient, durable and magnetically recoverable heterogeneous catalysts for catalytic transfer hydrogenation of biomass-derived furfural as well as other aldehydes with 2-propanol as the H-donor forming furfuryl alcohol and various aromatic/allyl/alkenyl alcohols, respectively.
Triphenylstannyl((arylimino)methyl)benzoates with selective potency that induce G1 and G2/M cell cycle arrest and trigger apoptosis via ROS in human cervical cancer cells
Authors: Basu Baul Tushar S. , Longkumer Imliwati , Duthie Andrew , Singh Priya , Koch Biplob , Guedes da Silva M. Fátima C.
Published: December 2017

Newly synthesized triphenylstannyl 4-((arylimino)methyl)benzoates show enhanced cytotoxicity and excellent selectivity in vitro towards human cervical cancer cells.
A(VO2F)(SeO3) (A = Sr, Ba) and Ba(MOF2)(TeO4) (M = Mo, W): first examples of alkali-earth selenites/tellurites with a fluorinated d0-TM octahedron
Authors: Liang Ming-Li , Ma Yun-Xiang , Hu Chun-Li , Kong Fang , Mao Jiang-Gao
Published: December 2017

First examples of alkali-earth selenites/tellurites with a fluorinated d0-TM octahedron, namely, A(VO2F)(SeO3) (A = Sr 1, Ba 2) and Ba(MOF2)(TeO4) (M = Mo 3, W 4), were synthesized successfully by hydrothermal reactions.
Tuning the redox profiles of polyoxovanadate-alkoxide clusters via heterometal installation: toward designer redox Reagents
Authors: VanGelder L. E. , Brennessel W. W. , Matson E. M.
Published: December 2017

Herein, we describe a rational synthetic approach for tuning the electrochemical profiles of a series of Lindqvist polyoxovanadate-alkoxide clusters through heterometal functionalization.
Foliar surface free energy affects platinum nanoparticle adhesion, uptake, and translocation from leaves to roots in arugula and escarole
Authors: Kranjc Eva , Mazej Darja , Regvar Marjana , Drobne Damjana , Remškar Maja
Published: December 2017

Low arugula surface free energy enhanced platinum nanoparticle adsorption, with decreased uptake and translocation to roots relative to escarole.
Correction: Wastewater from hydraulic fracturing in the UK: assessing the viability and cost of management
Authors: O'Donnell M. C. , Gilfillan S. M. V. , Edlmann K. , McDermott C. I.
Published: December 2017

Correction for ‘Wastewater from hydraulic fracturing in the UK: assessing the viability and cost of management’ by M. C. O'Donnell et al., Environ. Sci.: Water Res. Technol., 2018, DOI: 10.1039/c7ew00474e.
Ruthenium(ii) oxidase catalysis for C–H alkenylations in biomass-derived γ-valerolactone
Authors: Bechtoldt Alexander , Baumert Marcel E. , Vaccaro Luigi , Ackermann Lutz
Published: December 2017

Ruthenium(ii) biscarboxylate oxidase catalysis is a powerful tool for the assembly of functionalized arenes with oxygen as a green oxidant. An improved level of sustainability has been achieved with the biomass-derived GVL as solvent.
The combination of endolysosomal escape and basolateral stimulation to overcome the difficulties of “easy uptake hard transcytosis” of ligand-modified nanoparticles in oral drug delivery
Authors: Cui Yi , Shan Wei , Zhou Rui , Liu Min , Wu Lei , Guo Quan , Zheng Yaxian , Wu Jiawei , Huang Yuan
Published: December 2017

Ligand-modified nanoparticles (NPs) are an effective tool to increase the endocytosis efficiency of drugs, but these functionalized NPs face the drawback of “easy uptake hard transcytosis” in the oral delivery of proteins and peptides.
2D end-to-end carbon nanotube conductive networks in polymer nanocomposites: a conceptual design to dramatically enhance the sensitivities of strain sensors
Authors: Pu Jun-Hong , Zha Xiang-Jun , Zhao Min , Li Shengyao , Bao Rui-Ying , Liu Zheng-Ying , Xie Bang-Hu , Yang Ming-Bo , Guo Zhanhu , Yang Wei
Published: December 2017

A highly sensitive strain sensor with end-to-end CNT networks and showing a high gauge factor (248) at small strain (5%) is fabricated.
Iodine(iii)-mediated intramolecular sulfeno- and selenofunctionalization of β,γ-unsaturated tosyl hydrazones and oximes
Authors: Yu Jing-Miao , Cai Chun
Published: December 2017

A cascade radical cyclization/sulfenylation or selenylation of β,γ-unsaturated hydrazones and oximes was realized under mild conditions with phenyliodine(iii) diacetate (PIDA) as the sole oxidant, leading to the construction of diversely functionalized heteroatom-containing pyrazoline and isoxazoline derivatives.
Ecofriendly preparation of graphene sheets decorated with an ethylenediamine copper(ii) complex composite modified electrode for the selective detection of hydroquinone in water
Authors: Sakthinathan Subramanian , Kokulnathan Thangavelu , Chen Shen-Ming , Karthik Raj , Chiu Te-Wei
Published: December 2017

A reduced graphene oxide decorated copper(ii) ethylenediamine complex composite modified electrode was applied for the electrochemical determination of hydroquinone.
Nanocomposite of MoO2 and MoC loaded on porous carbon as an efficient electrocatalyst for hydrogen evolution reaction
Authors: Lv Cuncai , Huang Zhipeng , Yang Qianpeng , Zhang Chi
Published: December 2017

MoO2/MoC@C nanocomposite was synthesized by an ultrasonic spray pyrolysis, and the synergic effect between MoO2 and MoC in hydrogen evolution reaction was demonstrated.
Treatment of real benzene dye intermediates wastewater by the Fenton method: characteristics and multi-response optimization
Authors: Guo Ying , Xue Qiang , Zhang Huanzhen , Wang Ning , Chang Simiao , Wang Hui , Pang Hao , Chen Honghan
Published: December 2017

Benzene dye intermediates (BDI) wastewater has caused major environmental concern due to its potential carcinogenic, teratogenic, and mutagenic effects.
Chetracins E and F, cytotoxic epipolythiodioxopiperazines from the marine-derived fungus Acrostalagmus luteoalbus HDN13-530
Authors: Yu Guihong , Wang Yanjuan , Yu Rilei , Feng Yanyan , Wang Lu , Che Qian , Gu Qianqun , Li Dehai , Li Jing , Zhu Tianjiao
Published: December 2017

Three epipolythiodioxopiperazines with two new ones were isolated from a marine-derived fungus, and all of them exhibited extensive cytotoxicity.
An unexpected re-arrangement of the antibiotic carbapenem core to new 1,4-diazepin-5-one scaffolds
Authors: Peters Byron K. , Razuwika Rufaro , Samipillai Marivel , Arvidsson Per I. , Kruger Hendrik G. , Govender Thavendran , Naicker Tricia
Published: December 2017

Herein we report a peculiar organocatalyzed domino-reaction on the carbapenem core structure.
Microstructure dependence of performance degradation for intermediate temperature solid oxide fuel cells based on the metallic catalyst infiltrated La- and Ca-doped SrTiO3 anode support
Authors: Ni Chengsheng , Lu Lanying , Miller David N. , Cassidy Mark , Irvine John T. S.
Published: December 2017

High peak power density and slow performance degradation for Ni–Fe infiltrated LSCTA− anode resulted from a favourable interaction between NiFe and the perovskite backbone due to the formation of a Fe-rich oxide interface layer.
Overcoming blood–brain barrier by HER2-targeted nanosystem to suppress glioblastoma cell migration, invasion and tumor growth
Authors: Song Zhenhuan , Liu Ting , Chen Tianfeng
Published: December 2017

Herein we synthesize an HER2 antibody-conjugated selenium nanoparticle platform can efficiently deliver both therapeutic agents and diagnostic agents (superparamagnetic iron oxide nanoparticles) across the BBB into the tumor tissues and enhances their effects on brain tumor treatment and MR imaging.
Up-conversion quantum yields of SrF2:Yb3+,Er3+ sub-micron particles prepared by precipitation from aqueous solution
Authors: Kuznetsov S. , Ermakova Yu. , Voronov V. , Fedorov P. , Busko D. , Howard I. A. , Richards B. S. , Turshatov A.
Published: December 2017

Herein, we report near-infrared-to-visible up-conversion (UC) in SrF2:Yb3+,Er3+ sub-micron crystals prepared via a facile route in an aqueous solution.
Development of a Communicative Disorders Training Program for Rwanda: Joining the Dots
Authors: Mukara Kaitesi Batamuliza , Tumusiime David K. , Barrett Helen , Donner Segerien R. , Kagwiza Jeanne N. , Murenzi Joyce
Published: December 2017

Communication disabilities remain a challenge worldwide but more especially in the developing world. Unpublished data from the recently concluded categorization of persons with disabilities (PWDs) conducted in Rwanda estimated that approximately 40% of PWDs have a disorder of speech, language, or hearing. Based on challenges faced by clinicians during patient care, a decision to start a training program was reached and shared with university of Rwanda administration in 2012 to solicit support to offer the intended programs. The discussions and curricula planning culminated in a participatory stakeholder validation workshop in February 2016 with the purpose of brainstorming the way forward towards approval and implementation of the programs. Subsequently, in May 2016, a strategic planning workshop was held with the objective of mapping resources and budgeting for the long-term sustainability of the programs as well as establishment of the professions and employability of graduates. Currently, the important step is to get funding for the curricula implementation. Thus, this paper describes the process of development of two programs to train a cadre of professionals in communication disorders; specifically speech and language and audiology and solicits any potential and interested funder to partner with the University of Rwanda.
Transoral robotic surgery advantages and disadvantages: a narrative review
Authors: Voutyrakou Dialekti Athina , Papanastasis Athanasios , Chatsikian Melkon , Katrakazas Panagiotis , Koutsouris Dimitrios
Published: December 2017

Robots were used for the first time in surgery back in 1997. Since then abdominal surgeries ensued with robotic surgery ‘infiltrating’ urology, gynaecology, and thoracic surgery fields as well. Lately, robotic surgery methodologies found application in head and neck surgeries leading to the development of the transoral robotic surgery (TORS). So far TORS has improved work of surgeons dealing with the oropharynx, hypopharynx, larynx, nasopharynx, thyroid, parapharyngeal space and skull areas of the human body. However, with the introduction of such a new efficacious modality, new questions emerge regarding its integration. The purpose of this review is to provide a thorough analysis of the advantages and disadvantages of TORS according to methodologies that have already been applied, along with their economic aspects, surgery processes, benefits compared to conventional surgery techniques, clinical results and any research gaps. Results indicate that TORS technical advantages denote its quality and importance in the field of robotic surgery.
Models for microbial fuel cells: a critical review
Authors: Xia Chengshuo , Zhang Daxing , Zhu Yingmin , Guo Yongxian
Published: December 2017

Microbial fuel cells (MFCs) have been widely viewed as one of the most promising alternative renewable energy source. MFCs have attracted a large amount of interest in the past decade and much scientific effort has been dedicated to making this technology more efficient. MFCs are complex bioelectrochemical system that generates electrical energy by the catalytic reaction of organic substrates. The study of MFCs requires an interdisciplinary approach. Experimental method is time‐consuming and uneconomical. Modelling of MFCs is an effective way not only for thorough understanding the effects of operation conditions on the power generation performance, but also for the successful implementation of MFCs. The state of the art of MFCs modelling is present in this article. Models and modelling methods are elaborated based on the classification of mechanism‐based models and application‐based models. Furthermore, mechanism, advantages, drawbacks, and application fields of different models are illustrated.
Collaborative control strategy of power electronic transformer and fault current limiter in DC microgrid
Authors: Kong Liang , Nian H
Published: December 2017

With rapid development of DC microgrid (DCMG), the protection against short circuit fault on the whole DC system has gained widespread concern. This paper proposes an approach which uses power electronic transformer (PET) and fault current limiters (FCLs) to improve the impact of short circuit current in DCMG. FCL in the fault line can work in the fault current limiting mode to limit short circuit current in this line. PET adjusts the input power from AC grid to DC grid to keep the DC voltage stability in the DCMG. A complete model of PET and DCMG is developed and the collaborative control strategy of PET and FCL is analysed. The simulation results confirm that the proposed control strategy based on the collaborative operation of PET and FCL can enhance the ability to ride through the short circuit fault of each part of DCMG system.
Siting and sizing method of energy storage system of microgrid based on power flow sensitivity analysis
Authors: Wang Haifeng , Lv Qing , Yang Geng , Geng Hua
Published: December 2017

Energy storage system (ESS) plays a power balance role in a microgrid integrated with many distributed renewable generators, but the cost and the lifetime of ESS like battery pack are weighted against the mass application, so it is of great significance to improve the efficiency of ESS. This study proposes a sitting and sizing method of ESS based on power flow analysis and multi‐objective optimisation. The method focuses on the optimal solution in terms of the control performance, line power losses and capacity of the ESS. A design process based on power flow sensitivity is described at the same time. A ten‐node microgrid model is selected for the validation of the method and simulations show the effectiveness.
The lithium-rotation connection in the 125 Myr-old Pleiades cluster
Authors: Bouvier J. , Barrado D. , Moraux E. , Stauffer J. , Rebull L. , Hillenbrand L. , Bayo A. , Boisse I. , Bouy H. , DiFolco E. , Lillo-Box J. , Morales Calderón M.
Published: December 2017

Context. The evolution of lithium abundance over a star’s lifetime is indicative of transport processes operating in the stellar interior. Aims. We revisit the relationship between lithium content and rotation rate previously reported for cool dwarfs in the Pleiades cluster.

Methods. We derive new LiI 670.8 nm equivalent width measurements from high-resolution spectra obtained for low-mass Pleiades members. We combine these new measurements with previously published ones, and use the Kepler K2 rotational periods recently derived for Pleiades cool dwarfs to investigate the lithium-rotation connection in this 125 Myr-old cluster.

Results. The new data confirm the correlation between lithium equivalent width and stellar spin rate for a sample of 51 early K-type members of the cluster, where fast rotating stars are systematically lithium-rich compared to slowly rotating ones. The correlation is valid for all stars over the (J–Ks) color range 0.50–0.70 mag, corresponding to a mass range from about 0.75 to 0.90 M⊙, and may extend down to lower masses.

Conclusions. We argue that the dispersion in lithium equivalent widths observed for cool dwarfs in the Pleiades cluster reflects an intrinsic scatter in lithium abundances, and suggest that the physical origin of the lithium dispersion pattern is to be found in the pre-main sequence rotational history of solar-type stars.
A tail like no other
Authors: Volwerk Martin , Goetz Charlotte , Richter Ingo , Delva Magda , Ostaszewski Katharina , Schwingenschuh Konrad , Glassmeier Karl-Heinz
Published: December 2017

Context. The Rosetta Plasma Consortium (RPC) magnetometer (MAG) data during the tail excursion in March–April 2016 are used to investigate the magnetic structure of and activity in the tail region of the weakly outgassing comet 67P/Churyumov–Gerasimenko (67P).

Aims. The goal of this study is to compare the large scale (near) tail structure with that of earlier missions to strong outgassing comets, and the small scale turbulent energy cascade (un)related to the singing comet phenomenon.

Methods. The usual methods of space plasma physics are used to analyse the magnetometer data, such as minimum variance analysis, spectral analysis, and power law fitting. Also the cone angle and clock angle of the magnetic field are calculated to interpret the data.

Results. It is found that comet 67P does not have a classical draped magnetic field and no bi-lobal tail structure at this late stage of the mission when the comet is already at 2.7 AU distance from the Sun. The main magnetic field direction seems to be more across the tail direction, which may implicate an asymmetric pick-up cloud. During periods of singing comet activity the propagation direction of the waves is at large angles with respect to the magnetic field and to the radial direction towards the comet. Turbulent cascade of magnetic energy from large to small scales is different in the presence of singing as without it.
A Novel 18F-Labeling Method for the Synthesis of [18F]-Piperidine-Containing Ligands as Potential PET Radiotracers for σ Receptors
Authors: Li Zibo , Wang Qiu , Ortiz Gerardo , Chansaenpak Kantapat , Wang Mengzhe , Ma Xiaofen , Wang Hui
Published: December 2017

We report a novel 18F-labeling method for the preparation of 18F-containing piperidine derivatives. This method is demonstrated on the design and synthesis of 18F-labeled potential PET radiotracers of σ receptors for initial biological evaluations.

1 Introduction

2 Design and Synthesis of Novel [19F]-3 and [
19F]-3′

3 Radiosynthesis of Novel [18F]-3 and [18F]-3′

4 In vivo Uptake and Pharmacokinetics of [18F]-3 and [18F]-3′

5 Conclusion
Management of Destructive Colon Injuries after Damage Control Surgery
Authors: Prakash Priya , Symons William , Chamieh Jad
Published: December 2017

After the World War II, fecal diversion became the standard of care for colon injuries, although medical, logistic, and technical advancements have challenged this approach. Damage control surgery serves to temporize immediately life-threatening conditions, and definitive management of destructive colon injuries is delayed until after appropriate resuscitation. The bowel can be left in discontinuity for up to 3 days before edema ensues, but the optimal repair window remains within 12 to 48 hours. Delayed anastomosis performed at the take-back operation or stoma formation has been reported with variable results. Studies have revealed good outcomes in those undergoing anastomosis after damage control surgery; however, they point to a subgroup of trauma patients considered to be “high risk” that may benefit from fecal diversion. Risk factors influencing morbidity and mortality rates include hypotension, massive transfusion, the degree of intra-abdominal contamination, associated organ injuries, shock, left-sided colon injury, and multiple comorbid conditions. Patients who are not suitable for anastomosis by 36 hours after damage control may be best managed with a diverting stoma. Failures are more likely related to ongoing instability, and the management strategy of colorectal injury should be based mainly on the patient's overall condition.
Whole Exon Deletion in the GFAP Gene Is a Novel Molecular Mechanism Causing Alexander Disease
Authors: Green Lydia , Berry Ian , Childs Anne-Marie , McCullagh Helen , Jose Sandhya , Warren Dan , Craven Ian , Camm Nick , Prescott Katrina , van der Knaap Marjo , Sheridan Eamonn , Livingston John
Published: December 2017

Alexander disease (AD) is a leukodystrophy caused by heterozygous mutations in the gene encoding the glial fibrillary acidic protein (GFAP). Currently, de novo heterozygous missense mutations in the GFAP gene are identified in over 95% of patients with AD. However, patients with biopsy-proven AD have been reported in whom no GFAP mutation has been identified. We report identical twin boys presenting in infancy with seizures and developmental delay in whom MR appearances were suggestive of AD with the exception of an unusual, bilateral, arc of calcification at the frontal white–gray junction. Initial mutation screening of the GFAP gene did not identify a mutation. Whole exome sequencing in both brothers revealed a de novo heterozygous in-frame deletion of the whole of exon 5 of the GFAP gene. Mutations in the GFAP gene are thought to result in a toxic effect of mutant GFAP disrupting the formation of the normal intermediate filament network and resulting in Rosenthal fiber formation, which has hitherto not been linked to exonic scale copy number variants in GFAP. Further studies on mutation negative AD patients are warranted to determine whether a similar mechanism underlies their disease.
Comparison of Cervicovaginal Cytopathological Samples Collected in Basic Health Units and in Private Clinics in the Midwest of Santa Catarina
Authors: Dallazem Bárbara , Dambrós Bibiana Paula , Gamba Conrado de Oliveira , Perazzoli Marcelo , Kirschnick Alexandre
Published: December 2017

Objective To compare the quality of cervicovaginal samples obtained from basic health units (BHUs) of the Unified Health System (SUS) and those obtained from private clinics to screen precursor lesions of cervical cancer.

Methods It was an intervention study whose investigated variables were: adequacy of the samples; presence of epithelia in the samples, and cytopathological results. A total of 940 forms containing the analysis of the biological samples were examined: 470 forms of women attended at BHUs of the SUS and 470 forms of women examined in private clinics in January and February of 2016.

Results All the unsatisfactory samples were collected at BHUs and corresponded to 4% of the total in this sector (p < 0.0001). There was a higher percentage of samples containing only squamous cells in the SUS (43.9%). There was squamocolumnar junction (SJC) representativeness in 82.1% of the samples from the private clinics (p < 0.0001). Regarding negative results for intraepithelial lesions and/or malignancies, the percentages obtained were 95.9% and 99.1% (p < 0.0049) in the exams collected in the private system and SUS, respectively. Less serious lesions corresponded to 0.89% of the samples from the SUS and 2.56% of the tests from the private sector; more serious lesions were not represented in the samples obtained from BHUs, whereas the percentage was 1.49% in private institutions.

Conclusion Unsatisfactory cervical samples were observed only in exams performed at the SUS. There is a need for guidance and training of professionals who perform this procedure to achieve higher reliability in the results and more safety for women who undergo this preventive test.
Staging des Lungenkarzinoms nach der revidierten TNM-Klassifikation
Authors: Niehoff Julius , Diederich Stefan , Höink Anna
Published: December 2017

Das Lungenkarzinom ist eine der häufigsten Krebserkrankungen des Menschen. Die komplexen und häufig multimodalen Therapiekonzepte dieses Krankheitsbildes setzen eine exakte Klassifikation jedes Tumors anhand von Tumorgröße (T), Lymphknotenstatus (N) und Fernmetastasen (M) voraus. Die TNM-Klassifikation für Lungentumoren ist von der International Association for the Study of Lung Cancer (IASLC) kürzlich in der 8. Auflage veröffentlicht worden.
Neurodevelopmental Outcome in Children With Single Ventricle After Total Cavopulmonary Connection
Authors: Vahsen Nicole , Bröder Arndt , Hraska Viktor , Schneider Martin
Published: December 2017

Background The purpose of the present study was to assess a broad range of neuropsychological outcome variables in children with functionally single ventricle hearts after a total cavopulmonary connection and to examine potential risk factors for impaired neurodevelopment.

Patients & Method A total of 104 patients aged 2 to 20 years underwent follow-up standardized psychological testing, including measures of intelligence, motor function, visuospatial abilities, behavioural outcome and health-related quality of life.

Results With a mean fluid intelligence score of 93.0 and a mean crystallized intelligence score of 92.3, patients scored significantly lower on tests of intelligence compared to the general population (p<0.001). Reduced motor function was found in 34% of the patients (p<0.001), impaired visuospatial abilities in 51%; parents reported significantly more behavioural problems (p<0.001). There was no difference in the self-reported quality of life compared to the general population. Risk factors for reduced fluid intelligence were deep hypothermic circulatory arrest times (p=0.03) and complications causing suboptimal brain perfusion prior to the total cavopulmonary connection (e. g. seizures; p=0.04).

Conclusions Patients with functionally single ventricle hearts palliated with a total cavopulmonary connection are at an increased risk of neurodevelopmental delays and behavioural disorders. Nevertheless, they adapt well in terms of quality of life. Early diagnostics and interventions are necessary when developmental delays are suspected.
Code of Conduct Digital Health der Deutschen Diabetes Gesellschaft
Authors: Müller-Wieland Dirk , Ickrath Manuel
Published: December 2017

Die „digitale Transformation“ verändert alle Gesellschafts- und Lebensbereiche – und damit auch die Medizin und Diabetologie. Eine medizinisch-wissenschaftliche Fachgesellschaft, wie die Deutsche Diabetes Gesellschaft (DDG), sollte den wissenschaftlich und ethisch basierten „medizinischen Standard“ für diesen primär durch Technik getriebenen Wandel formulieren. Forderungen, die sich daraus ergeben, müssen erkennbar zusammengefasst werden und damit einen „Handlungsrahmen“ für Akteure im Gesundheitswesen definieren: Dies soll der „Code of Conduct Digital Health“ (CoC DH) der DDG leisten.