bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the assortment of ice wine in online stores in Ukraine
Authors: Krupitskaya L. , Lutskova V.
Published: July 2020

Unbalanced structure of the assortment leads to the decrease in the level of proft, loss of the competitive position of enterprises, including wine ones, in promising markets. In the conditions of the modern wine market, there is a tendency to increase consumer inﬂuence on the formation of the assortment range of wineries, focusing on wines with original consumer properties, in particular ice.
Ice wine is a rare wine of a special type, the technology of which involves the use of non-classical methods of processing grapes. Therefore, ice wine is characterized by original consumer properties leading to increased interestamong consumers who increasingly use distance means of buying goods.In this regard, in this article the monitoring of the ice wine assortment was conducted, which is presented on the sites of Ukrainian online stores, both general retail and specialized wine networks.Coefcient estimation methods were used to evaluate the assortment of ice wines based on comparison with the benchmark system. According to the results of the study, the low coefcients of breadth and depth of ice wine assortment presented in the onlinestoresin Ukraine were obtained.
It was determined that most ice wines are wines of foreign producers made from Riesling grapes. The Rozetka online store has the entire list of ice wines on sale, but the largest assortment of ice wines from around the world is not available for orders on the website of the specialized wine online store Wine Style. It should be noted that not a single position of ice wine was found in the online stores of Ukrainian grocery retail chains. Therefore, the subsequent formation of an assortment of ice wines is an urgent task, which will allow us to correctly propose eﬀective methods to increase the competitiveness of ice wines on the Ukrainian retail market.
It was determined that most ice wines are wines of foreign producers made from Riesling grapes. The Rozetka online store has the entire list of ice wines on sale, but the largest assortment of ice wines from around the world is not available for orders on the website of the specialized wine online store Wine Style. It should be noted that not a single position of ice wine was found in the online stores of Ukrainian grocery retail chains. Therefore, the subsequent formation of an assortment of ice wines is an urgent task, which will allow us to correctly propose eﬀective methods to increase the competitiveness of ice wines on the Ukrainian retail market.
Key words: assortment, market, online store, ice wine, depth ofassortment, breadth of assortment.
In Àuence factors for enterprise free cash Àow: correlation and regression analysis
Authors: Rohanova H.
Published: July 2020

A specific informative indicator allowing judging enterprise movement through its life cycle stages is a Free Cash Flow (FCF). Differences in FCF determining considerably influence its calculation and further analysis methods. Thus the issue of FCF size determination algorithm formalization arises. The present time need in practical usage of certain applied aspects regarding the enterprise FCF management stipulates the research issues and thesis relevance as well.
The aim – identification of both negative and positive influence factors for the confectionary enterprises FCF by means of correlation and regression analysis; checking of the selected influence factors statistical meaning and model adequacy.
The article refers to the correlation and regression analysis, liner regression. It allows transferring from factors functional relation and effective indicator to scholastic dependence. The correlation and regression analysis allows the task solving: to determine the analytical form of relation between the effective and factor indicators as well as define their density relation level.
The correlation analysis is held for 15 confectionary enterprises FCF size in 2002-2018 and 85 indicators of No1-3 financial accounting forms indicators in the first case. According to the correlation analysis results 10 influence factors possessing the close relation with FCF size are chosen.
Pre-requisite availability of independent and not related factors in the regression modelresults in their reduction to 5. The greatest reverse influence makes the enterprise income from the capital assets sell and financial investments; its correlation coefficient is equal to -0.76. The other factors possess the correlation coefficient meaning at the visible and high level. The received empiric linear regression equation possesses multiple correlation effect on 0.9 level. The hypothesis on heteroscedastic model absence is confirmed.
The model received according to the correlation and regression analysis results is adequate and statistically meaningful. The offered model application allows forecasting the general FCF indicator meaning for confectionary industry enterprises as well as determining tendencies in the future and managing it in general.
Key words: free cash flow, NOPAT, financial result, cash flow report, confectionary enterprise, correlation analysis, regression analysis, model, heteroscedasticity.
Seeds laboratory similarity of introduced Callistephus chinensis (L.) Ness.
Authors: Polischuk V. , Turchyna S. , Karpuk L. , Balabak A. , Osipov M. , Pavlichenko A.
Published: July 2020

Laboratory similarity of introduced Chinese calisthephus varieties has been investigated with a view to further using seedlings in soil conditions of the best genotypes. Also, the main task was to determine the actual intensity of seeds germination in the studied varieties of Chinese callistephus in the laboratory.
The studies uexamined 20 introduced varieties of Chinese calisthephus plants with diff erent characteristics, origin and direction of use, with their further study on the main economic and valuable features for landscaping. As a result of the studies conducted on the similarity of Chinese introduced calicephus varieties seeds with diff erent economic traits, productivity and direction of use, the genotypes were isolated and grouped, on average over the years, with high, medium and low coeffi cient of similarity.
Accordingly, the germination control was performed starting from the fourth day after sowing. It should be noted that the sprouts were not recorded in six varieties, respectively – in the Malynovyi shar, Esmeralda, Vesnyanka, Syedaya Dama, Salmon Turm and Sofi a. The varieties of Oksamyt, Oksana, Princess and Amber had a similarity rate of 10 %.
Medium and high rates of seed germination (50–90 %) were recorded in the varieties of Odarka, Hilda, Snizhana, Anastasia (Soph.), Winter Cherry, Alexandra, Swan Lake and King Size (red), which will further enable the respective varieties research on the study of economic biological, and most importantly the decorative properties of introduced varieties for the purpose of their further use in the landscape gardening.
Key words: genotype, Chinese callistephus, varieties, introduction, economically valuable traits, decorative, seed germination, multiplication factor.
Effect of living mulch on physiological and biochemical parameters of cherry leaves and fruits with organic growing technology
Authors: Gerasko T.
Published: July 2020

In organic sweet cherry (Prunus avium L./Prunus mahaleb) orchard standard mechanical cultivation was compared with living mulch – spontaneous vegetation cover. Since 2013 the experimental orchard has been maintained with two different orchard ﬂoor management systems: standard mechanical cultivation (MC) – one discing at a 15 cm depth + manual weeding during the growing season was compared with living mulch (LM) – spontaneous vegetation cover. The natural vegetation of grasses was mowed 4 times during the growing season and the clippings were left on the ground for decomposition. Any other management was identical in each treatment. Synthetic fertilizers and chemical plant protection products were not used. It was established that total moisture content of the leaves was signiﬁcantly reduced under LM (over 2 years) or did not diﬀer signiﬁcantly from MC (1 year). The water-retaining ability of the leaves did not diﬀer signiﬁcantly between LM and MC (2 years) or was higher in the conditions of LM (1 year). The total leaf area at the beginning of the study (1 year) was larger in MC conditions. In the following year, the diﬀerence between LM and MC was insigniﬁcant. In 2019, the total leaf area was signiﬁcantly larger in the conditions of LM. An increase in the total leaf area under LM conditions led to a signiﬁcant decrease in the speciﬁc surface density of the leaves, the accumulation of chlorophylls in them, and a decrease in the ratio of chlorophylls (a/b) due to an increase in the content of chlorophyll b (compared to the MC conditions). The diﬀerence in fruit size parameters, average weight of the fruits, total soluble solids, total sugars, titratable acidity, sugar-acid index were insigniﬁcant between LM and MC. Ascorbic acid and total anthocyanins content of sweet cherry fruit was signiﬁcantly increased under LM conditions compared to MC. The results show that cherry trees gradually adapt to coexistence with natural herbs and, during stress, accumulate more physiologically active substances in the fruit. Key words: sweet cherry, organic orchard, living mulch, total leaf area, speciﬁc leaf density, chlorophylls, fruit size, ascorbic acid, anthocyanins.
Characteristic of spelt-like forms of wheat created with hybridization of Triticum aestivum L. × Triticum spelta L.
Authors: Diordiieva I.
Published: July 2020

A number of new wheat samples have been created as a result of hybridization of soft and spelt wheat. Wheat samples were selected with individual family selection among the oﬀspring. The samples were characterized by considerable diversity in morphological and biological characteristics. Forms that diﬀer signiﬁcantly in plant height were observed among the created oﬀspring. The range of variability on this trait was 55–118 cm. 1561 sample diﬀered positively in the weight of grain from the ear, which signiﬁcantly exceeded the Star of Ukraine variety and did not diﬀer signiﬁcantly on this trait from the Podolyanka variety. 1561 sample was positively diﬀerent in yielding capacity (6,66 t/ha). It was signiﬁcantly higher than Star of Ukraine variety and not signiﬁcantly inferior to the Podolyanka variety. In terms of protein and gluten content, the sample 162 containing 44.3 % of gluten and 21.4 % of protein was the best. A signiﬁcant increase of the weight of 1000 grains relative to both standards was recorded in sample 1710 (59.2 g). We have identiﬁed samples in which the earning and ripening were recorded at the level of early ripening soft wheat varieties. Samples 1710 and 1809 have a vegetation period of 280–285 days and their yielding capacity signiﬁcantly exceeding the Star of Ukraine variety (5.77–6.02 t/ha).
A number of new spelt-like forms of wheat were created with the use of remote hybridization of soft and spelt wheat. The obtained forms were analyzed in terms of economic value and found suitable for introduction in breeding improvement schemes. 2. Forms that combine high productivity with high grain quality, in particular sample 1561 containing 36.4 % of gluten, 17.5 % of protein and has yields 6.66 t/ha were selected. 3. Artaplot variety was created with hybridization of soft and spelt wheat; the variety is listed in the State Register for Plant Varieties Suitable for Distribution in Ukraine since 2018.
Key words: plant height, protein content, gluten content, yielding capacity, variety.
The inﬂuence of biostimulants and microbiological preparation on the production process of peas (Pisum sativum L.) in the drought Steppe of Ukraine
Authors: Kolesnykov M. , Ponomarenko S. , Paschenko Yu.
Published: July 2020

The use of plant growth bioregulators and microbiological preparations stimulates growth processes, improves nitrogen nutrition, and enhances crop resistance to adverse conditions. Therefore, the aim of the work was to elucidate the characteristics of the additive effect of biostimulants (Stimpo, Regoplant) and the microbiological preparation Azotoﬁt-R on the growth, development, formation of a photoassimilating apparatus and the productivity of peas Oplot variety in the dry Steppe of Ukraine.
Presowing and foliar treatments with biological products were made in the doses recommended by the manufacturers. The number of root nodules was calculated, the leaf area index, the content of chlorophyll were determined, and the netto-photosynthesis productivity was calculated in the experiment. The structural elements of the biological productivity of pea crops were recorded.
It is established that Stimpo and Regoplant combined with Azotoﬁt-r contributed to increase in the numbers of nodules by 14–17 % till ﬂowering stage in comparison with the variants under the separate application of biostimulants. Presowing treatment of peas seeds and foliar treatment with more active leaves surface formation was noticed under combined application of biopreparations compared to separate one and it promoted the raise of netto-photosynthesis. Synergistic interaction of biostimulants (Stimpo, Regoplant) with bioactivator (Azotoﬁt) was observed in the processes of chlorophyll synthesis and accumulation. Combined interaction of Stimpo, Regoplant with Azotoﬁt rised the beans number per plant by 8 % to 28 %, and weight of 1000 seeds by 4.4 % to 6.3 % respectively. Under separate application of Azotoﬁt, Stimpo, Regoplant, the biological yield of peas crop was 3.4, 3.8 and 3.4 t/ha. Whereas, under combined application of biopreparations (Azotoﬁt+Stimpo) the yield was – 4.4 t/ha and (Azotoﬁt+Regoplant) – 4.2 t/ha and its exceeded the control yield (3.1 t/ha) of peas.
These data conﬁrm the results of biopreparations positive inﬂuence on legumine biological productivity, which indicates a future perspective to research the productive processes under biopreparations eﬀect.
Key words: biostimulator, Rehoplant, Stimpo, Azotoﬁt, pea, photoassimilation apparatus, yield.
Winter wheat varieties productivity of on elements of growing technology under the conditions of Southern Step of Ukraine
Authors: Markovska O. , Hrechyshkina T.
Published: July 2020

Agrarian science has faced the problem of is the humanity provision with food, the major part of which is provided by grain crops. Winter wheat the most fully uses the existing bioclimatic potential of the Ukrainian regions. The highest productivity of this crop can be obtained with the use of modern adapted varieties with high genetic potential of productivity taking into account the soil-climatic conditions of the zone, improvement and development of highly effi cient, scientifi cally grounded systems of nutrition and plants protection against harmful organisms.
The article presents the results of the research conducted in 2017–2019 on dark brown medium-loam low-saline soils under the conditions of the experimental fi eld of State Enterprise Experimental Farm “Kopani” of the Institute of Irrigated Agriculture of NAAS of Bilozersky district of Kherson region. The infl uence of varietal characteristics, mineral and organic-mineral fertilizer system, biological and chemical methods of disease protection on the productivity of winter wheat plants was investigated. The fi eld, laboratory, mathematical and statistical methods were used in the experiment according to the generally accepted methods and
guidelines in Ukraine.
It was found out that the highest level of productivity was formed by wheat plants of Maria winter variety on the background of application of pre-sowing cultivation of mineral fertilizers at a N30P30 dose with the use of foliar
fertilization with organic-mineral fertilizer ROST, solution (2.0 l/ha) at the beginning of the restoration of spring vegetation and in a stage of the fl ag leaf and chemical protection of plants using fungicide – Colossal, emulsion concentrate (1.0 l/ha). Thus, on average during the years of research, the grain yield in this variant was 4.96 t/ha, the number of productive stems – 411 pieces/m2, the number of grains in the ear – 27.6 pieces, the mass of 1000 grains – 51.5g. When using the chemical method of protection to control dark brown spotting (Drechslera sorociniana Subram) of winter wheat, the rate of development of the disease ranged 2.0–3.1 %, and the eff ectiveness ranged 83.1 – 89.4 %.
Key words: fertilizers, biologicals, fungicide, yield, foliar feeding, plant protection.
IMPROVEMENT OF WRITING SKILL OF PANTUN USING THE FIELDTRIP METHOD FOR ELEMENTARY SCHOOL STUDENTS
Authors: Vista Aprima , Arief Darnis
Published: July 2020

This research is motivated by the low ability in writing Pantun for elementary school students. The purpose of this study was to determine the improvement of the ability to write pantun for elementary school students using the field trip method. This research was a classroom action research carried out in grade 5 of SDN 01 Nan Sabaris, Padang Pariaman Regency consisting of 30 students. The research procedure consisted of planning, implementing, observing, and reflecting. Data collection techniques used the method of observation, measurement of learning test results and documentation. Data analysis techniques consisted of quantitative data. Quantitative data used to analyze the results of the ability to write Pantun by measuring the percentage of mastery learning and class average. The results showed that the students' initial ability score in writing rhymes was 67.00, cycle I got a score of 72.00, and cycle II got a score of 83.00. This research proved that there was an increase in the ability to write rhymes for elementary school students using the field trip method. The implication of this research is to be used as a reference for teachers in implementing the learning process of Pantun writing for elementary school students.
Venous cerebral infarction in patient with thrombophilia while taking hormonal drugs
Authors: Putilina M. V. , Ermoshkina N. Yu. , Sidelnikova L. V.
Published: July 2020

A clinical case of venous cerebral infarction in a patient with congenital thrombophilia without thrombosis of cerebral venous sinuses is presented. Etiology, diagnosis and treatment of venous heart attacks are considered. Particular attention is paid to methods of diagnosis and therapy.
ANALISIS PERBANDINGAN PELACAKAN OBJEK MENGGUNAKAN ALGORITMA HORN-SCHUNCK DAN LUCAS-KANADE
Authors: Supriyatin Wahyu
Published: July 2020

Object tracking one of computer vision. Computer vision similar to human eye function. The difficulty is to detect presence an object and object tracking application made. Object tracking used in aircraft, track cars, human body detectors at airports, a regulator the number of vehicles pass and navigation tools on robots. This study is to identify objects that pass in frame. This research also count the number of objects that pass in one frame. Object tracking done by comparing two algorithms namely Horn-Schunck and Lucas-Kanade. Both algorithms tested using the Source Block Parameter and Function Block Parameter. The test carried out with video resolution 120x160 and the position camera is 2-4 m. The object tracking test is conducted in the duration of 110-120 seconds. Stages tracking object was thresholding, filtering and region successfully obtain object binary video. The Lucas-Kanade has faster in identifying objects compared to the Horn-Schunck algorithm.
PERBANDINGAN KINERJA METODE PRA-PEMROSESAN DALAM PENGKLASIFIKASIAN OTOMATIS DOKUMEN PATEN
Authors: Nugroho Budi , Denih Asep
Published: July 2020

This paper presents a performance analysis and comparison of several pre-processing methods used in automatic patent classification with graph kernels for Support Vector Machine (SVM). The pre-processing methods are based on the data transform techniques, namely data scaling, data centering, data standardization, data normalization, the Box-Cox transform and the Yeo-Johnson transform. The automatic patent classification is designed to classify an input of patent citation graphs into one of 10 possible classes of the International Patent Classification (IPC). The input is taken with various background conditions. The experiments showed that the best result is achieved when the pre-processing method is data normalization, achieving a classification accuracy of up to 85.33.15% for the KEHL and 93.80% for the KVHL. In contrast, for the KEHG, the preprocessing method application decreased the accuracy.
KEMAMPUAN SPASIAL SISWA SMP DALAM MEMECAHKAN MASALAH GEOMETRI RUANG BERDASARKAN KECERDASAN SPASIAL DAN KECERDASAN LOGIKA
Authors: Faizah Siti
Published: July 2020

Matematika merupakan mata pelajaran yang penting, sehingga matematika diajarkan pada tingkat SD sampai perguruan tinggi. Salah satu materi yang diajarkan pada siswa sejak SD adalah tentang geometri, kemudian pada tigkat SMP materi tersebut dikembangkan menjadi geometri ruang. Dalam mempelajari geometri ruang tidak terlepas dari kemampuan spasial karena kemampuan spasial merupakan kemampuan untuk menghasilkan, menyimpan, mengambil dan mengubah gambar tiga dimensi yang terstruktur dengan baik. Sehingga kemampuan spasial siswa SMP dalam memecahkan masalah geometri ruang yakni siswa mampu berusaha mengembangkan kemampuan penginderaan spasialnya yang sangat berguna dalam memahami relasi dan sifat-sifat dalam geometri untuk memecahkan masalah matematika dan masalah dalam kehidupan sehari-hari serta dapat menumbuhkan kemampuan berfikir logis, mengembangkan kemampuan memecahkan masalah dan pemberian alasan.Kata Kunci: Kemampuan spasial, geometri ruang, kecerdasan spasial dan kecerdasan logika
Impact of Cytokines and Phosphoproteins in Response to Chronic Joint Infection
Authors: Prince Nicole , Penatzer Julia A. , Dietz Matthew J. , Boyd Jonathan W.
Published: July 2020

The early cellular response to infection has been investigated extensively, generating valuable information regarding the mediators of acute infection response. Various cytokines have been highlighted for their critical roles, and the actions of these cytokines are related to intracellular phosphorylation changes to promote infection resolution. However, the development of chronic infections has not been thoroughly investigated. While it is known that wound healing processes are disrupted, the interactions of cytokines and phosphoproteins that contribute to this dysregulation are not well understood. To investigate these relationships, this study used a network centrality approach to assess the impact of individual cytokines and phosphoproteins during chronic inflammation and infection. Tissues were taken from patients undergoing total knee arthroplasty (TKA) and total knee revision (TKR) procedures across two tissue depths to understand which proteins are contributing most to the dysregulation observed at the joint. Notably, p-c-Jun, p-CREB, p-BAD, IL-10, IL-12p70, IL-13, and IFN-γ contributed highly to the network of proteins involved in aseptic inflammation caused by implants. Similarly, p-PTEN, IL-4, IL-10, IL-13, IFN-γ, and TNF-α appear to be central to signaling disruptions observed in septic joints. Ultimately, the network centrality approach provided insight into the altered tissue responses observed in chronic inflammation and infection.
Modulation of Renal Injury by Variable Expression of Myo-Inositol Oxygenase (MIOX) via Perturbation in Metabolic Sensors
Authors: Sharma Isha , Deng Fei , Kanwar Yashpal
Published: July 2020

Obesity is associated with perturbations in cellular energy homeostasis and consequential renal injury leading to chronic renal disease (CKD). Myo-inositol oxygenase (MIOX), a tubular enzyme, alters redox balance and subsequent tubular injury in the settings of obesity. Mechanism(s) for such adverse changes remain enigmatic. Conceivably, MIOX accentuates renal injury via reducing expression/activity of metabolic sensors, which perturb mitochondrial dynamics and, if sustained, would ultimately contribute towards CKD. In this brief communication, we utilized MIOX-TG (Transgenic) and MIOXKO mice, and subjected them to high fat diet (HFD) administration. In addition, ob/ob and ob/MIOXKO mice of comparable age were used. Mice fed with HFD had increased MIOX expression and remarkable derangements in tubular injury biomarkers. Decreased expression of p-AMPKα (phospho AMP-activated protein kinase) in the tubules was also observed, and it was accentuated in MIOX-TG mice. Interestingly, ob/ob mice also had decreased p-AMPKα expression, which was restored in ob/MIOXKO mice. Parallel changes were observed in Sirt1/Sirt3 (silent mating type information regulation 2 homolog), and expression of other metabolic sensors, i.e., PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) and Yin Yang (YY-1). In vitro experiments with tubular cells subjected to palmitate-BSA and MIOX-siRNA had results in conformity with the in vivo observations. These findings link the biology of metabolic sensors to MIOX expression in impaired cellular energy homeostasis with exacerbation/amelioration of renal injury.
Changes in Circulating Extracellular Vesicles in Patients with ST-Elevation Myocardial Infarction and Potential Effects of Remote Ischemic Conditioning—A Randomized Controlled Trial
Authors: Haller Paul M. , Jäger Bernhard , Piackova Edita , Sztulman Larissa , Wegberger Claudia , Wojta Johann , Gyöngyösi Mariann , Kiss Attila , Podesser Bruno K. , Spittler Andreas , Huber Kurt
Published: July 2020

(1) Background: Extracellular vesicles (EVs) have been recognized as a cellular communication tool with cardioprotective properties; however, it is unknown whether cardioprotection by remote ischemic conditioning (RIC) involves EVs. (2) Methods: We randomized patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) to additionally receive a protocol of RIC or a sham-intervention. Blood was taken before and immediately, 24 h, four days and one month after PCI. Additionally, we investigated EVs from healthy volunteers undergoing RIC. EVs were characterized by a high-sensitive flow cytometer (Beckman Coulter Cytoflex S, Krefeld, Germany). (3) Results: We analyzed 32 patients (16 RIC, 16 control) and five healthy volunteers. We investigated platelet-, endothelial-, leukocyte-, monocyte- and granulocyte-derived EVs and their pro-thrombotic sub-populations expressing superficial phosphatidylserine (PS+). We did not observe a significant effect of RIC on the numbers of circulating EVs, although granulocyte-derived EVs were significantly higher in the RIC group. In line, RIC had not impact on EVs in healthy volunteers. Additionally, we observed changes of PS+/PEV, EEVs and PS+/CD15+ EVs irrespective of RIC with time following STEMI. 4) Conclusion: We provide further insights into the course of different circulating EVs during the acute and sub-acute phases of STEMI. With respect to the investigated EV populations, RIC seems to have no effect, with only minor differences found for granulocyte EVs.
Adjuvant Therapy Reduces Fat Mass Loss during Exercise Prescription in Breast Cancer Survivors
Authors: Mascherini Gabriele , Tosi Benedetta , Giannelli Chiara , Ermini Elena , Osti Leonardo , Galanti Giorgio
Published: July 2020

Improvements in cancer care over the years have increased the numbers of cancer survivors. Therefore, quality of life, fat mass management and physical activity are growing areas of interest in these people. After the surgical removal of a breast cancer, adjuvant therapy remains anyway a common strategy. The aim of this study was to assess how adjuvant therapy can affect the effectiveness of an unsupervised exercise program. Forty-two women were enrolled (52.0 ± 10.1 years). Assessments performed at baseline and after six months of exercise prescription were body composition, health-related quality of life, aerobic capacity by Six-Minute Walk Test, limbs strength by hand grip and chair test and flexibility by sit and reach. Statistical analyses were conducted by ANOVA tests and multiple regression. Improvements in body composition, physical fitness and quality of life (physical functioning, general health, social functioning and mental health items) were found. The percentage change in fat mass has been associated with adjuvant cancer therapy (intercept = −0.016; b = 8.629; p < 0.05). An unsupervised exercise prescription program improves body composition, physical fitness and health-related quality of life in breast cancer survivors. Adjuvant therapy in cancer slows down the effectiveness of an exercise program in the loss of fat mass.
Multiphase Storm Deposits Eroded from Andesite Sea Cliffs on Isla San Luis Gonzaga (Northern Gulf of California, Mexico)
Authors: Guardado-France Rigoberto , Johnson Markes E. , Ledesma-Vázquez Jorge , Santa Rosa-del Rio Miguel A. , Herrera-Gutiérrez Ángel R.
Published: July 2020

The 450-m long spit that extends westward from the northwest corner of Isla San Luis Gonzaga is one of the largest and most complex constructions of unconsolidated cobbles and boulders found anywhere in Mexico’s Gulf of California. The material source derives from episodic but intense storm erosion along the island’s andesitic cliff face with steep northern exposures. A well-defined marine terrace from the late Pleistocene cuts across the same corner of the island and provides a marker for the subsequent development of the spit that post-dates tectonic-eustatic adjustments. A total of 660 individual andesite clasts from seven transects across the spit were measured for analyses of change in shape and size. These data are pertinent to the application of mathematical formulas elaborated after Nott (2003) and subsequent refinements to estimate individual wave heights necessary for lift from parent sea cliffs and subsequent traction. Although the ratio of boulders to clasts diminishes from the proximal to distal end of the structure, relatively large boulders populate all transects and the average wave height required for the release of joint-bound blocks at the rocky shore amounts to 5 m. Based on the region’s historical record of hurricanes, such storms tend to decrease in intensity as they migrate northward through the Gulf of California’s 1100-km length. However, the size and complexity of the San Luis Gonzaga spit suggests that a multitude of extreme storm events impacted the island in the upper gulf area through the Holocene time, yielding a possible average growth rate between 7 and 8 m/century over the last 10,000 years. In anticipation of future storms, a system to track the movement of sample boulders should be emplaced on the San Luis Gonzaga spit and similar localities with major coastal boulder deposits.
Corporate Governance Quality, Ownership Structure, Agency Costs and Firm Performance. Evidence from an Emerging Economy
Authors: Rashid Khan Haroon ur , Khidmat Waqas Bin , Hares Osama Al , Muhammad Naeem , Saleem Kashif
Published: July 2020

The purpose of this paper is to investigate the effect of corporate governance quality and ownership structure on the relationship between the agency cost and firm performance. Both the fixed-effects model and a more robust dynamic panel generalized method of moment estimation are applied to Chinese A-listed firms for the years 2008 to 2016. The results show that the agency–performance relationship is positively moderated by (1) corporate governance quality, (2) ownership concentration, and (3) non-state ownership. State ownership has a negative effect on the agency–performance relationship. Various robust tests of an alternative measure of agency cost confirm our main conclusions. The analysis adds to the empirical literature on agency theory by providing useful insights into how corporate governance and ownership concentration can help mitigate agency–performance relationship. It also highlights the impact of ownership type on the relationship between agency cost and firm performance. Our study supports the literature that agency cost and firm performance are negatively related to the Chinese listed firms. The investors should keep in mind the proxies of agency cost while choosing a specific stock. Secondly; the abuse of managerial appropriation is higher in state-held firms as compared to non-state firms. Policymakers can use these results to devise the investor protection rules so that managerial appropriation can be minimized.
Eating Disorders in Pregnant and Breastfeeding Women: A Systematic Review
Authors: Martínez-Olcina María , Rubio-Arias Jacobo A. , Reche-García Cristina , Leyva-Vela Belén , Hernández-García María , Hernández-Morante Juan José , Martínez-Rodríguez Alejandro
Published: July 2020

Background and objectives: Pregnancy is a stage associated with various biopsychosocial changes. These changes, along with concerns about keeping an adequate weight, can modulate an individual’s risk for psychological disorders, especially eating disorders (EDs). The aim of this review was to investigate the prevalence, associated risks, and consequences of eating disorders in pregnancy and in breastfeeding mothers. Materials and Methods: A systematic review was carried out following the PRISMA guidelines in the scientific databases: PubMed, Web of Science, Scopus, and PsycINFO. Search terms related to EDs, pregnancy, and breastfeeding were used. The evaluation of the methodological quality of the studies was carried out using different scales; CASP (Checklist for Cohort Study), NICE (Methodology Checklist for Cohort Study), ARHQ (Methodology Checklist for Cross-Sectional), and NOS (Newcastle-Ottawa Scale for Cohort). Results: From 2920 studies, 16 were selected to study EDs in pregnant women and 2 studies in nursing mothers. Most of the studies used questionnaires and scales as tools for the diagnosis of EDs. Binge eating, anxiety, and depression were the most common comorbidities of EDs, accompanied in most cases by excessive concern about weight gain. The consequences of EDs are diverse. The prevalence of EDs in this population is estimated to be 1 out of 20. Conclusions: Eating disorders are related to anxiety and depression and have negative consequences for both mothers and fetuses (cesarean, miscarriages, premature births). More research on the field to determine the risk factors for EDs in the population of pregnant and lactating women is needed.
Inhibition of Salmonella Binding to Porcine Intestinal Cells by a Wood-Derived Prebiotic
Authors: Božić Aleksandar , Anderson Robin C. , Crippen Tawni L. , Swaggerty Christina L. , Hume Michael E. , Beier Ross C. , He Haiqi , Genovese Kenneth J. , Poole Toni L. , Harvey Roger B. , Nisbet David J.
Published: July 2020

Numerous Salmonella enterica serovars can cause disease and contamination of animal-produced foods. Oligosaccharide-rich products capable of blocking pathogen adherence to intestinal mucosa are attractive alternatives to antibiotics as these have potential to prevent enteric infections. Presently, a wood-derived prebiotic composed mainly of glucose-galactose-mannose-xylose oligomers was found to inhibit mannose-sensitive binding of select Salmonella Typhimurium and Escherichia coli strains when reacted with Saccharomyces boulardii. Tests for the ability of the prebiotic to prevent binding of a green fluorescent protein (GFP)-labeled S. Typhimurium to intestinal porcine epithelial cells (IPEC-J2) cultured in vitro revealed that prebiotic-exposed GFP-labeled S. Typhimurium bound > 30% fewer individual IPEC-J2 cells than did GFP-labeled S. Typhimurium having no prebiotic exposure. Quantitatively, 90% fewer prebiotic-exposed GFP-labeled S. Typhimurium cells were bound per individual IPEC-J2 cell compared to non-prebiotic exposed GFP-labeled S. Typhimurium. Comparison of invasiveness of S. Typhimurium DT104 against IPEC-J2 cells revealed greater than a 90% decrease in intracellular recovery of prebiotic-exposed S. Typhimurium DT104 compared to non-exposed controls (averaging 4.4 ± 0.2 log10 CFU/well). These results suggest compounds within the wood-derived prebiotic bound to E. coli and S. Typhimurium-produced adhesions and in the case of S. Typhimurium, this adhesion-binding activity inhibited the binding and invasion of IPEC-J2 cells.
SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders
Authors: Benazzo Marco , Cassaniti Irene , Maiorano Eugenia , Calastri Anna , Novazzi Federica , Bonetti Alice , Sarasini Antonella , Bruno Raffaele , Baldanti Fausto
Published: July 2020

The main object of the study was to investigate the SARS-CoV-2 molecular and serological pattern in patients with mild symptoms including anosmia and ageusia. A cohort of 69 patients with olfactory and taste disorders (OTDs) were enrolled and prospectively monitored. Serological and molecular assays for the characterization of SARS-CoV-2 IgG and SARS-CoV-2 RNA, respectively, were performed at the time of enrolment and after 7 and 14 days. Patients were stratified according to the symptoms’ onset. A total of 52 patients (75.4%) were diagnosed as COVID-19 positive being SARS-CoV-2 RNA and/or SARS-CoV-2 IgG positive. The remaining 17 (24.6%) were negative for COVID-19 and excluded from the analysis. We reported that only 34 out of 52 patients (65.4%) were positive for SARS-CoV-2 RNA. Moreover, the median time from onset of symptoms and enrolment was significantly higher in those patients with negative SARS-CoV-2 RNA in nasal swabs, suggesting that symptoms might last longer than SARS-CoV-2 replication. The great majority of patients (80%) developed SARS-CoV-2 IgG at three weeks after symptoms’ onset while the detectability of SARS-CoV-2 RNA dramatically decreased over time, suggesting the crucial role of combination of molecular and serological assays for the diagnosis of COVID-19 in those patients reporting mild symptoms.
Lipids by Yarrowia lipolytica Strains Cultivated on Glucose in Batch Cultures
Authors: Carsanba Erdem , Papanikolaou Seraphim , Fickers Patrick , Erten Huseyin
Published: July 2020

Oleaginous microorganisms, such as Yarrowia lipolytica, accumulate lipids that can have interesting applications in food biotechnology or the synthesis of biodiesel. Y. lipolytica yeast can have many advantages such as wide substrate range usage and robustness to extreme conditions, while under several culture conditions it can produce high lipid productivity. Based on this assumption, in this study, 12 different Yarrowia lipolytica strains were used to investigate microbial lipid production using a glucose-based medium under nitrogen-limited conditions in shake-flask cultivations. Twelve wild-type or mutant strains of Yarrowia lipolytica which were newly isolated or belonged to official culture collections were tested, and moderate lipid quantities (up to 1.30 g/L) were produced; in many instances, nitrogen limitation led to citric acid production in the medium. Lipids were mainly composed of C16 and C18 fatty acids. Most of the fatty acids of the microbial lipid were unsaturated and corresponded mainly to oleic, palmitic and linoleic acids. Linolenic acid (C18:3) was produced in significant quantities (between 10% and 20%, wt/wt of dry cell weight (DCW)) by strains H917 and Po1dL.
Experimental Study on Biomass Heating System in the Greenhouse: A Case Study in Xiangtan, China
Authors: Huang Tao , Li Hongqiang , Zhang Guoqiang , Xu Feng
Published: July 2020

To meet the indoor heat load demand of greenhouses in China rural areas in winter, the authors proposed and designed a novel biomass heating system in greenhouses. The system uses biomass flue gas as the thermal working medium and heats the shallow soil inside the greenhouse through the buried flue gas-soil heat exchanger, thereby improving the indoor thermal environment of the greenhouse. To further study the heating system performance, we built up the heating experimental platform in a plastic greenhouse. Through testing the actual operation effect of the biomass heating system of the plastic greenhouse, no taking any heating measures system, the biomass heating system of the plastic greenhouse can improve the air average temperature and the soil average temperature 5.1 °C and 8.2 °C, respectively. The greenhouse biomass heating system is very economical, compared with the greenhouse without heating system, which can bring a 105% excess return rate for farmers every year. This study has obvious significance to promote the sustainable development of rural agriculture and the efficient utilization of rural biomass resources.
A Plausible Model of Inflation Driven by Strong Gravitational Wave Turbulence
Authors: Galtier Sébastien , Laurie Jason , Nazarenko Sergey V.
Published: July 2020

It is widely accepted that the primordial universe experienced a brief period of accelerated expansion called inflation. This scenario provides a plausible solution to the horizon and flatness problems. However, the particle physics mechanism responsible for inflation remains speculative with, in particular, the assumption of a scalar field called inflaton. Furthermore, the comparison with the most recent data raises new questions that encourage the consideration of alternative hypotheses. Here, we propose a completely different scenario based on a mechanism whose origins lie in the nonlinearities of the Einstein field equations. We use the analytical results of weak gravitational wave turbulence to develop a phenomenological theory of strong gravitational wave turbulence where the inverse cascade of wave action plays a key role. In this scenario, the space-time metric excitation triggers an explosive inverse cascade followed by the formation of a condensate in Fourier space whose growth is interpreted as an expansion of the universe. Contrary to the idea that gravitation can only produce a decelerating expansion, our study reveals that strong gravitational wave turbulence could be a source of inflation. The fossil spectrum that emerges from this scenario is shown to be in agreement with the cosmic microwave background radiation measured by the Planck mission. Direct numerical simulations can be used to check our predictions and to investigate the question of non-Gaussianity through the measure of intermittency.
MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals
Authors: Stunnenberg Melissa , van Pul Lisa , Sprokholt Joris K. , van Dort Karel A. , Gringhuis Sonja I. , Geijtenbeek Teunis B. H. , Kootstra Neeltje A.
Published: July 2020

The mitochondrial antiviral protein MAVS is a key player in the induction of antiviral responses; however, human immunodeficiency virus 1 (HIV-1) is able to suppress these responses. Two linked single nucleotide polymorphisms (SNPs) in the MAVS gene render MAVS insensitive to HIV-1-dependent suppression, and have been shown to be associated with a lower viral load at set point and delayed increase of viral load during disease progression. Here, we studied the underlying mechanisms involved in the control of viral replication in individuals homozygous for this MAVS genotype. We observed that individuals with the MAVS minor genotype had more stable total CD4+ T cell counts during a 7-year follow up and had lower cell-associated proviral DNA loads. Genetic variation in MAVS did not affect immune activation levels; however, a significantly lower percentage of naïve CD4+ but not CD8+ T cells was observed in the MAVS minor genotype. In vitro HIV-1 infection of peripheral blood mononuclear cells (PBMCs) from healthy donors with the MAVS minor genotype resulted in decreased viral replication. Although the precise underlying mechanism remains unclear, our data suggest that the protective effect of the MAVS minor genotype may be exerted by the initiation of local innate responses affecting viral replication and CD4+ T cell susceptibility.
Profitability of Frequency Regulation by Electric Vehicles in Denmark and Japan Considering Battery Degradation Costs
Authors: Calearo Lisa , Marinelli Mattia
Published: July 2020

This paper determines the profitability of the primary frequency regulation (FR) service considering the wear of the electric vehicle (EV) battery as a cost. To evaluate the profitability of the FR service, the cost of degradation from FR provision is separated from the degradation caused by driving usage. During FR, the power response is proportional to the frequency deviation with full activation power of 9.2 kW, when deviations are larger than 100 mHz. The degradation due to FR is found to be an additional 1–2% to the 7–12% capacity reduction of a 40 kWh Lithium-ion NMC battery pack over 5 years. The overall economic framework is applied in Denmark, both DK1 and DK2, and Japan, by considering historical frequencies. The DK2 FR market framework is taken as reference also for the Japanese and the DK1 cases. Electricity prices and charger efficiency are the two main parameters that affect the profitability of the service. Indeed, with domestic prices there is no profitability, whereas with industrial prices, despite differences between the frequencies, the service is similarly profitable with approx. 3500€ for a five-year period.
Some Aspects of the Development of Medical Transplantology in the Works of Russian Authors (Literature Review)
Authors: Balayan A.
Published: July 2020

Despite the statistically substantiated relevance of the transplantation procedure among patients, there is an acute problem of the shortage of donor organs associated with various problems of a social, ethical and scientific nature in Russia. These problems have a significant impact on the development of national transplantology, affect the formation of areas of medical thought. During the period of absence of an alternative of an effective care for patients with severe organ failure, continuous improvement of the federal regulatory framework in the field of transplantology is required, as well as the study of the experience of other countries.
Low-frequency ultrasound and photochromotherapy in the complex treatment of patients with chronic bacterial and viral rhinosinusitis
Authors: Kornova Natalya , Krylov A.
Published: July 2020

The article presents results of a study on the effectiveness of using lowfrequency ultrasound and photochromotherapy in the complex treatment of patients with chronic bacterial and viral rhinosinusitis. The study involved 69 people aged 18 to 55 years: 39 (56.83 %) women and 30 (45.11 %) men with chronic rhinosinusitis during the period of clinical exacerbation and concomitant chronic tonsillitis without exacerbation. All patients included in the study underwent X-ray examination or computed tomography and magnetic resonance imaging of the paranasal sinuses. 100 % of the patients were examined for the presence of antibodies to Human gammaherpesvirus 4 (ELISA), had study of blood serum for IgM and IgG and test to determine the avidity of Ig G antibodies to γ-herpesviruses. The obtained data indicate the effectiveness of including low-frequency ultrasound and photochromotherapy in the complex treatment of patients with chronic rhinosinusitis and concomitant chronic tonsillitis of bacterial and viral nature without exacerbation.
Features of immunogenesis in various types of pregnancy
Authors: Levkova E. , Savin S. , Gulieva K.
Published: July 2020

The article presents cell-mediated mechanisms of immunological relationship in various types of pregnancy and demonstrates immunotypes characteristic of the physiological and pathological course of gestation. Disturbance of immune homeostasis in complicated pregnancy ranged from autoimmune one with the threat of miscarriage to severe immunosuppressive condition with gestosis.