bluuebunny/crossref_metadata_2025 huggingface dataset:
The roles of a light-dependent protochlorophyllide oxidoreductase (LPOR), and ATP-dependent dark operative protochlorophyllide oxidoreductase (DPOR) in chlorophyll biosynthesis
Authors: SUN Wenli , SHAHRAJABIAN Mohamad H. , CHENG Qi
Published: September 2021

Chlorophyll is a green photosynthetic pigment, and photosynthesis drives the global carbon cycle. The reduction of protochlorophyllide (Pchlide) to chlorophyllide (Chlide) in the penultimate stage of biosynthesis of chlorophyll (Chl) is catalyzed by light-independent protochlorophyllide reducatse (DPOR), and the light-dependent protochlorophyllide oxidoreductase (LPOR). The search was done to all manuscript sections according to terms chlorophyll, a light-dependent protochlorophyllide oxidoreductase, ATP-dependent dark operative protochlorophyllide oxidoreductase, chlorophyll, photosynthesis and chlorophyllide. Within the framework of photosynthesis and chlorophyll, this review article was aimed to provide an overview of the functional studies in chlorophyll biosynthesis, protein crystal structure, disclosure of action mechanisms, and possible future available direction of LPOR and DPOR in the biosynthesis of chlorophyll.
Children with congenital heart disease in COVID-19 pandemic times: an integrative review
Authors: Silva Aline Cerqueira Santos Santana da , Góes Fernanda Garcia Bezerra , Silva Liliane Faria da , Silva Laura Johanson da , Bonifácio Michelly Cristynne Souza , Coelho Yasminn Canella Cabral Banjar
Published: September 2021

ABSTRACT Objective: to identify the scientific production in health about children with congenital heart disease in COVID-19 pandemic times. Method: this is an integrative review, carried out in June 2020 in the information resources Latin American and Caribbean Literature in Health Sciences (LILACS), National Library of Medicine, National Institutes of Health (PubMed), Scientific Electronic Library Online Journal Portal (SciELO) and Brazilian Institute of Information Science and Technology (Oasis Ibict). Results: 14 studies composed this review. Most studies pointed to tests, interventional procedures and surgery for children with heart disease in pandemic times; others discussed possible complications of COVID-19 among children with congenital heart disease. Conclusion: the incipient production of studies and the weak level of evidence denote an important knowledge gap so far, highlighting the need for studies with strong scientific evidence for the formulation of care guidelines aimed at children with heart disease.
Incidence of acute radiodermatitis in women with breast cancer undergoing hypofractionated radiotherapy
Authors: Martelletti Laura Beatriz Sousa de Jesus , Aguiar Beatriz Regina Lima de , Vieira Larissa Aparecida Corrêa , Menêses Amanda Gomes de , Bontempo Priscila de Sousa Maggi , Ferreira Elaine Barros , Reis Paula Elaine Diniz dos
Published: September 2021

ABSTRACT Objective: To estimate the incidence and degree of acute radiodermatitis at the end and after the end of treatment in women with breast cancer undergoing hypofractionated radiotherapy. Methods: Observational, prospective, and longitudinal study, conducted between March 2019 and January 2020, in a radiotherapy outpatient clinic. Results: Thirty-two women participated in the study, among whom, in the last session of hypofractionated radiotherapy, 15 (46.9%) had radiodermatitis, erythema in 13 (40.6%), and wet peeling in 2 (6.3%). In the post-treatment evaluation, 27 (84.4%) had radiodermatitis, erythema in 17 (53.1%), dry peeling in 8 (25%), and wet peeling in 2 (6.3%). Conclusion: The general incidence of radiodermatitis after hypofractionated radiotherapy in women with breast cancer was 37.5%, erythema, 12.5%, and dry peeling, 25%. The development of care protocols for the management of radiodermatitis after treatment is of paramount importance.
Assessment of stigma and prejudice in the organization of care networks for drug users
Authors: Santos Elitiele Ortiz dos , Pinho Leandro Barbosa de , Silva Aline Basso da , Eslabão Adriane Domingues
Published: September 2021

ABSTRACT Objective: To assess stigma and prejudice in the organization of the Psychosocial Care Network for drug users. Methods: this is a qualitative study, developed through Empowerment Assessment. The survey was conducted in a municipality in Rio Grande do Sul, with 42 network workers. For data collection, participant observation, semi-structured interviews and open forum were used. For data analysis, thematic analysis was used. Results: the network’s mission involved a proposal for care without prejudice and judgments for drug users. It was identified that the composition of the network with training in multidisciplinary residency and psychiatry facilitates achieving the mission, and among the difficulties, the challenges to overcome prejudice were analyzed. Strategies for continuing education, seminars, and user empowerment in the community are suggested. Final considerations: stigma and prejudice need to be problematized in the networks for the organization of more inclusive and rehabilitating psychosocial care.
Ciência e ética em Popper: a ética da responsabilidade dos cientistas
Authors: Dias Elizabeth de Assis
Published: September 2021

Resumo: O presente trabalho tem por objetivo analisar as relações entre ciência e ética em Popper, mais precisamente, a natureza dessa ética que está na base de sua teoria da ciência. A pretensão é evidenciar que sua concepção de ciência está alicerçada em uma ética da responsabilidade, a qual pressupõe a autonomia dos cientistas, sua liberdade de escolha, o que os torna responsáveis por suas decisões por determinados “padrões” de pesquisa. Almeja-se mostrar que essa ética da responsabilidade já se faz presente em sua lógica da investigação, de forma pouco explícita, quando suas preocupações estão voltadas para o problema da demarcação científica e sua proposta de um critério de cientificidade e de uma metodologia para a ciência. A adoção de tal proposta requer dos cientistas uma decisão que envolve objetivos e valores. Em escritos, nos quais expressa suas preocupações com questões éticas inerentes a ciência, essa ética da responsabilidade se apresenta de forma nítida, ao definir certos compromissos para os cientistas, tendo por base o juramento de Hipócrates, bem como os princípios éticos que devem nortear suas pesquisas.
Reflexões sobre o ninguém na obra de Hannah Arendt
Authors: Almeida Vanessa Sievers de
Published: September 2021

Resumo: Em sua obra As origens do totalitarismo, Hannah Arendt afirma que os regimes totalitários evidenciaram que é possível transformar pessoas em seres supérfluos, isto é, elementos substituíveis e descartáveis. Já em seus escritos tardios, como os da coletânea Responsabilidade e julgamento, a pensadora se refere ao ninguém, um ser humano que deixou de ser uma pessoa. Assim, embora sob diferentes designações, o ninguém aparece em vários pontos de sua obra. Neste artigo, procuro compreender essa figura, estabelecendo contrapontos com a figura do alguém, ou do quem, e com a do “egoísta”. Arendt mesma não usa o termo “egoísta”, mas é possível pensar que a distinção entre ele e o ninguém ajuda a caracterizar o último com maior nitidez, como um fenômeno próprio da sociedade de massa, em especial dos regimes totalitários. Espero mostrar como as figuras extremas do ninguém e do alguém e, em algum ponto entre os extremos, a do egoísta se tornam profícuas, não só para compreender algumas experiências analisadas por Arendt, mas também para pensar sobre as nossas.
Subsídios para uma discussão da formação das estrelas na sala de aula
Authors: Horvath J. E.
Published: September 2021

As novas diretrizes da Base Nacional Comum Curricular sugere Unidades Temáticas onde os temas de Estrutura e Evolução das Estrelas têm um lugar natural. Porém, um levantamento recente mostrou que o tema da Formação das Estrelas quase nem é abordado na literatura. Apresentamos neste trabalho um panorama completo deste assunto com a intenção de fornecer subsídios para seu tratamento em sala de aula, atualizado e acessível aos professores da Ciências.
Transitional Era: from analogical to digital workflow in oral rehabilitation: a case report
Authors: ZAVOLSKI Adrielly , GRANVILLE Francielly , POMINI Marcos Cezar , OLIVEIRA Fabio Brasil de , PINHEIRO Lidia Olga Bach , RUNNACLES Patricio , SAMRA Adriana Postiglione Buhrer
Published: September 2021

ABSTRACT Digital dentistry is a ubiquitous phenomenon nowadays but it requires access to technologies and learning curve. To aid digital workflow implementation, digital steps can be progressively incorporated in conventional workflows. We aimed to demonstrate a multidisciplinary oral rehabilitation performed mixing conventional procedures with digital open-source software programs and low-cost devices. A 46-year-old female patient had photographs, intraoral scans, and cone-beam computed tomography obtained and used in combination with conventional clinical exams to develop a treatment plan. Power point software was used for digital smile planing and Horos for digital implant planning. The digital dataset were used to guide conventional clinical procedures (scaling and root planning, gingivoplasty, in-office tooth bleaching, fiber-post restoration, implant and bone graft placement, teeth preparation, and protheses design and milling). The inclusion of digital steps in the conventional workflow enabled the performance of rehabilitation procedures with reduced clinical time and increased predictability, favoring the overall workflow and the communication among the different dental specialties. A mixed workflow can progressively lead to an exclusively digital workflow as technologies become accessible and learning curve is coped.
Family literacy in preschoolers’ linguistic and metalinguistic skill development
Authors: Borges Monica Teixeira , Azoni Cíntia Alves Salgado
Published: September 2021

ABSTRACT Purpose: to verify family literacy practices with preschoolers from a public school in a municipality of the Northeast Region of Brazil. Methods: 21 parents/guardians of pre-kindergarten and kindergarten students from a public school participated in this study. A questionnaire with 18 items on the parents’/guardians’ participation in family literacy practices was develop for this research. The resulting data underwent descriptive and inferential analysis, with the significance level set at 5%. Results: the preschoolers’ mean age was 69 months, and that of the parents/guardians who answered the questionnaire was 31 years. The educational level of most parents/guardians was either high school or unfinished middle school. A significant, positive relationship, between the parents’/guardians’ educational level and the following questionnaire items was seen: paying attention to the children when they spoke, calling their attention to the sound of letters and words, and teaching/encouraging them to write their names. Conclusion: family literacy practices are not commonly developed in the culture of the Northeast Region of Brazil, and when so, most of them are similar to activities taught at school. There was also a weak correlation between the parents’/guardians’ educational level and the family literacy practices.
Maternidad, migración y prematuridad: experiencias en una unidad de neonatología
Authors: Mira Andrea , Bastías Rodolfo
Published: September 2021

Resumen Los procesos migratorios son un fenómeno global que puede resultar en condiciones de vida más vulnerables. Dadas estas condiciones es que se hace relevante brindar los apoyos necesarios para las familias en situación de migración, donde algunos momentos críticos para esto serán el embarazo, el parto y la crianza. Es así como las mujeres migrantes viven su maternidad en un contexto cultural distinto y que dadas las condiciones de vida desfavorables pueden enfrentar dificultades en el embarazo, tales como el parto prematuro, lo que podría representar una experiencia traumática y estresante. Existen pocos estudios que aborden estas temáticas en Latinoamérica y es por esto que el objetivo de este estudio es describir las vivencias de madres migrantes con un hijo o hija de pretérmino hospitalizado/a en una unidad de neonatología. Se utilizó una metodología cualitativa con un enfoque fenomenológico. Se realizaron entrevistas en profundidad a 16 madres y de éstas emergieron temáticas relevantes tales como las diferencias culturales sobre la maternidad y crianza, las condiciones de vida, sus experiencias en el parto, y finalmente lo que significa ser madre es en un país diferente al suyo. Estos hallazgos permiten tener un mejor entendimiento sobre este fenómeno y podría facilitar el desarrollo de estrategias que favorecerían una maternidad respetuosa y multicultural en las unidades de neonatología.
Effects of shoot tip size on in vitro regeneration and virus elimination of grapevine cv. superior seedless
Authors: Saygaç Simin , Önder Serkan
Published: September 2021

In this study, we investigate the relation between the explant size and the success of virus elimination in ‘Superior Seedless’ grape variety. Plants were tested by prior to thermotherapy and in vitro culture by using Double Antibody Sandwich-Enzyme-Linked Immunosorbent Assay (DAS-ELISA) and Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and verified as infected by different viruses (Grapevine leafroll associated virus -1+3, Grapevine leafroll associated virus -4 Strains, Grapevine rupestris stem pitting associated virus). Different size of shoot tip explants (0.1-0.5-1-5-10 mm) were excised and cultured on MS medium supplemented with 1 mgl-1 BA. All of the explants bigger than 0.1 mm 100% regenerated while 70% of the 0.1 mm explants showed complete regeneration and turned into a whole plant. Plants regenerated from 10 mm shoot tip explants have all three viruses (GLRaV-1+3, GLRaV-4 strains and GRSPaV) as founded in mother plant. Plants regenerated from 5 mm explants have two of them (GLRaV-1+3, GLRaV-4 strains) and plants regenerated from 1 mm explants have one (GLRaV-1+3). Plants regenerated from 0.1 mm explants were found completely virus-free.
The Grammar of Leprosy: Temporal Politics and the Impossible Subject
Authors: Meek Laura A.
Published: September 2021

This research article critically interrogates the implications and unintended consequences of the World Health Organization’s purported elimination of leprosy as a public health problem. I explore how leprosy has been portrayed (for nearly a century) as something from the past, recalcitrantly lingering on into the present, but surely about to be gone—a temporal framing I call the ‘grammar of leprosy’. I recount the experiences of Daniel, my interlocutor in Tanzania, whose existence became a problem for his doctors. This problem they ultimately resolved by fabricating negative test results in order to record what they already knew: leprosy had been eliminated. I also analyse how researchers working for Novartis (the supplier of leprosy’s cure) continue to push for an always imminent ‘elimination’, while field researchers repeatedly caution about the potential problems of this approach. Finally, I reveal how the grammar of leprosy operates through a complex set of temporal politics, pulling into its orbit and being enabled by multiple interwoven temporalities. I conclude that—due to this grammar, the impossible subjects it produces, and the temporal politics through which it operates—leprosy elimination campaigns may have dire consequences for the lives of people with leprosy today, impeding rather than enabling treatment.
CECR : par ici la sortie !
Authors: Maurer Bruno , PUREN Christian
Published: September 2021

En février 2018, le Conseil de l’Europe publie, plus de 15 ans après le CECR, un Volume complémentaire censé parachever le document de 2001, avec de nouvelles échelles de descripteurs, notamment pour la médiation. Cet ajout tardif ignore toutes les critiques du CECR formulées entre-temps, comme si ce document était la référence indépassable et définitive en didactique des langues-cultures. Les trois premières parties de cet ouvrage CECR : par ici la sortie ! font une critique serrée de ces deux publications au terme de laquelle il apparaît que le projet du CECR et de son volume complémentaire peut être résumé en quelques mots : feindre de traiter d’enseignement-apprentissage-évaluation, mais ne travailler en réalité qu’à promouvoir une forme d’évaluation limitée et commerciale, à savoir la certification. Dans les deux premières parties, la mainmise d’intérêts privés sur le projet européen d’enseignement scolaire des langues est établie, preuves à l’appui, alors que la troisième partie met en lumière le grand nombre des impasses et insuffisances théoriques et pratiques du CECR, en particulier sa dépendance à une méthodologie unique, l’approche communicative. Les deux dernières parties tracent deux voies parallèles de sortie du Cadre, toutes deux dans une perspective résolument pluriméthodologique : une « évaluation intégrée » qui prend en compte l’ensemble des enjeux du processus d’enseignement-apprentissage des langues ; une « méthodologie plurilingue intégrée » qui s’appuie sur le déjà-là en termes de répertoire langagier des apprenants et sur le déjà-construit en termes de savoirs sur les langues et de compétences d’apprentissage des langues. La « sortie » du CECR est désormais ouverte, libre et large!
Natsume Soseki’nin Eserleri Üzerinden Japon Edebiyatı Öğretiminde Ulus Bilinci Kavramının Değerlendirilmesi
Authors: ATLI USTA Nihan
Published: September 2021

Ulus bilincinin oluşumunda, ortak dilin, kültürün ve tarihi olayların etkisi büyüktür. Uzun süre ülkesinin kapılarını kapamış Japonya için modern Japonya’nın temellerinin atıldığı Meiji Dönemi, ulus bilincinin oluşumunda önemli bir rol oynamaktadır. “Tek ulus, tek millet” (Tanabe, 2001:398-400) olduğu savunulan Japonya, bu süreçte Batı medeniyetini sindirerek, ulusun ayakta kalmasını sağlamak için “Zengin ülke, güçlü ordu” sloganıyla Batılı ülkeleri tanıyıp onların ilmini ve teknolojisini öğrenme yoluna gider. Bu çalışmada Japonya’nın ulus devlet bilincinin oluşturulduğu Meiji Dönemi yazarları dikkate alınarak Japonya’daki edebiyat öğretiminde ulus bilincinin nasıl biçimlendiği incelenmiştir. Japon Eğitim-Kültür-Spor-Bilim ve Teknoloji Bakanlığı (MEXT) açık kaynaklarında yer alan ders müfredatları, ders materyali kılavuzları ve ders kitapları incelendiğinde, ortaokul kitaplarında Natsume Sōseki’nin (1867-1916) Küçük Bey (Botchan『坊ちゃん』), lise kitaplarında Gönül (Kokoro『こころ』) eserlerinin müfredatlarına dahil edildiği gözlemlenmiştir. Eserlerin ders kitaplarına dahil edilen bölümleri incelendiğinde, ortaokul ders müfredatında yer alan Küçük Bey eseri ile geleneksel Japon ruhunun bilinci oluşturulurken, lise ders müfredatında yer alan Gönül eseriyle modern Japon insanının ruhunun öğretildiği anlaşılmıştır. Ayrıca müfredatın, geleneksel Japon ruhuyla, modern Japon ruhu arasında bir geçiş olacak şekilde düzenlenmesi ile ulus kimlik bilincinin pekiştirildiği düşünülmektedir. Yapılan bu çalışma ile geniş ölçekte “Edebiyatta Japon Ulus Bilincinin Yansıması”, dar ölçekte ise “Japonya’daki Edebiyat Öğretiminde Ulus Bilinci” üzerine yapılan çalışmalara yeni ve detaylı bir bakış açısı sunulmaktadır.
Japon İmparatorluğu’nun Kore’deki Yabancı Dil Olarak Japon Dili Eğitimi: Kim Sa-Ryang’ın Kurgusunda Japon Dili ve Kimlik
Authors: KABA Melek
Published: September 2021

Sömürge Kore’de 1910’dan sonra resmen uygulanmaya başlanan Japon dili eğitimi politikaları zaman içerisinde, entelektüel kimliği Japon dilinde yapılanan ve bu dilde edebi eserler verebilen bir nesli ortaya çıkarmıştır. Bu makale, Japon yönetimi döneminde Kore Yarımadası’nda uygulanan Japon dili eğitimi politikalarını tarihi süreci içerisinde ele almakta ve Koreli yazar Kim Saryang’ın “Işıklar İçinde (Hikari no Nakani)” adlı kurgusunda, Tokyo’da Koreli halkın kimliğinin konumlanışını, melezleşen kültür ve dil bağlamında tartışmaktadır. Kore asıllı yazarların içerisinde, Japonca yazılan edebiyat alanının öncülerinden olan Kim Saryang’ın Işıklar İçinde adlı kurmaca metni, Korelilerin Japonca konuşmak ve Korece konuşmak şeklindeki kültürel ve etnik kimliklerinin konumlanışlarını dile getirmektedir. Çalışmanın amacı, post kolonyal kuram çerçevesinde Japon İmparatorluğu tarafından uygulanan Kore’deki Japon dili Eğitiminin tarihini incelemek ve Kim Sa-Ryang’ın bu politikalara bakışını yazarın “Işıklar İçinde” adlı eseri üzerinden değerlendirmektir.
Türkiye’de Matematik Eğitimi Alanında Problem Çözmeye Yönelik Yapılan Çalışmaların Bir İçerik Analizi
Authors: COŞKUN Ayşegül , SOYLU Yasin
Published: September 2021

Bu çalışmada, 2000-2020 yılları arasında Türkiye’de matematik eğitimi alanında problem çözmeye yönelik çalışmaların içerik analiz yöntemiyle incelenmesi amaçlanmıştır. Çalışmada nitel araştırma yöntemlerinden durum çalışması deseni kullanılmıştır. Verilerin toplanmasında doküman inceleme, verilerin analizinde ise içerik analiz yöntemi kullanılmıştır. Bu çalışmada problem çözmeye yönelik çalışmaların yayım yılı, araştırma grupları, araştırma yöntemleri, veri toplama araçları ve sonuçlarına ait elde edilen veriler frekans ve yüzde hesaplamalarıyla grafik ve tablolar oluşturulmuş ve bulgulara ulaşılmıştır. Problem çözme ile ilgili çalışmalara bakıldığında 2005 yılından itibaren çalışmaların arttığı, en çok ortaokul öğrencileriyle çalışıldığı, en fazla nicel araştırma yöntemleri ile deneysel araştırma deseninin uygulandığı, test veri toplama aracının ise en fazla kullanıldığı belirlenmiştir. Rutin olmayan problem çözme ve yaratıcı problem çözme becerileri bakımından yeterli olmadığı, okuma becerisinin problem çözme becerisine etkisi olduğu, problemi anlama, plan yapma ve değerlendirme basamaklarında ise yetersizliklerin olduğu sonuçlarına ulaşılmıştır.
KEMİK VE EKLEM AĞRISI İLE BAŞVURAN AKUT LENFOBLASTİK LÖSEMİLİ ÇOCUK HASTALARIN KLİNİK, LABORATUVAR VE RADYOLOJİK ÖZELLİKLERİNİN DEĞERLENDİRİLMESİ
Authors: GUZELKUCUK Zeliha , YILMAZ Eymen , ISİK Melek , SİVRİ Mesut , YARALI Hüsniye Neşe
Published: September 2021

Amaç

Akut lenfoblastik lösemi (ALL) en sık görülen çocukluk

çağı kanseridir. Çabuk yorulma, morarma, kanama,

sebebi bilinmeyen ateş gibi şikayetlerin yanı sıra;

non-spesifik kemik ve eklem ağrısı ilk başvuru bulgusu

olabilmektedir. Bu çalışmanın amacı; kemik ve

eklem ağrısı şikayeti ile başvuran hastaların demografik

özelliklerini, laboratuvar bulgularını ve tedavi sonuçlarını

belirlemek, kemik eklem ağrısı olmayan ALL

hastaları ile karşılaştırmak ve kemik-eklem ağrısı olan

hastaların radyolojik bulgularını değerlendirmektir.

Gereç ve Yöntem

Sağlık Bilimleri Üniversitesi Ankara Çocuk Sağlığı ve

Hastalıkları Çocuk Hematoloji Onkoloji Eğitim Araştırma

Hastanesi Pediatrik Hematoloji Bilim Dalında,

Ocak 2013 – Haziran 2018 tarihleri arasında ALL tanısı

alan 163 hastanın dosyası retrospektif olarak incelendi.

Kemik ve eklem yakınmaları ile başvuran 33

hasta tespit edildi. Kemik eklem yakınması olan hastalar;

Grup I ve kemik eklem yakınması olmayan hastalar;

Grup II olarak sınıflandırıldı. Tüm hastaların tanı

sırasındaki demografik özellikleri, laboratuvar bulguları

ve son durumları geriye dönük olarak incelendi.

Bulgular

Grup I ve Grup II’ de yer alan hastalar arasında yaş,

cinsiyet, immünfenotiplendirme açısından istatistiksel

olarak anlamlı fark bulunmadı (p>0,05).Grup I’de; ortanca

başvuru beyaz küre değeri düşük ve trombosit

değeri ise daha yüksek saptandı (p
Chilean experience using “Theranostics” for treating metastatic neuroendocrine tumors with [177Lu]Lu DOTA-TATE
Authors: Horacio Amaral
Published: September 2021

Introduction: Well-differentiated, Neuroendocrine Tumors (NET) are highly heterogenic and slow-growing pathologies, characterized by unspecific symptomatology and elevated expression of somatostatin receptors (SSTR). Despite the high incidence of NETs, several patients are diagnosed in advance stages of the disease when surgery is insufficient to treat the pathology. Peptide receptor radionuclide therapy (PRRT) has emerged as a new state-of-the-art treatment for NET-patients in advanced stages. Results: In this retrospective study, between 2004 and 2018 a total of 66 patients with advanced-stage-NETs, refractory to other therapies, were treated with [177Lu]Lu DOTA TATE. At the end of the study, 56.1% of the patients were alive and the median overall survival for all patients in the study was 86.3 months. Patients that received doses ≥ 22.2 GBq showed increased overall survival (OS) in comparison with patients that received doses < 22.2 GBq (HR, 0.168; 95%CI 0.12- 0.99; p<0.001), adjusted by gender. Likewise, patients that received doses ≥29.6 GBq had an increased OS (HR, 0.42; 95%CI 0.19-0.94, p<0.05). Conclusion: Although several studies have shown that PRRT is an effective alternative for advanced NET, patients in South America have no regular access to PRRT. Our study proves that [177Lu]Lu-DOTA-TATE effectively increases the survival of patients with metastatic NET and provides an excellent alternative in terms of cost-efficiency for South American countries.
Cognitive impact in bipolar disorder
Authors: Michel Bourin
Published: September 2021

It appears that bipolar patients suffer from cognitive difficulties whereas they are in period of thymic stability. These intercritical cognitive difficulties are fairly stable and their severity is correlated with the functional outcome of patients. Nevertheless, the profile of cognitive impairment varies significantly from study to study quantitatively and qualitatively. According to the studies, the authors find difficulties in terms of learning, verbal memory, visual memory, working memory, sustained attention, speed of information processing, functions executive. On the other hand, deficits of general intelligence, motor functions, selective attention, and language are not usually found. One of the reasons for the heterogeneity of results is the difficulty of exploring cognition in bipolar disorder. Many factors must be taken into account, such as the presence of residual mood symptoms, the longitudinal history of the disorder (age of onset, number of episodes due, among others, the neurotoxic impact of depressive episodes and deleterious cognitive effects). (length of hospitalization), level of disability severity, comorbidities (particularly addictive).
Comparison of level of mental stress between exercising and non-exercising undergraduate physical therapy students of LUMHS, Jamshoro
Authors: Sana Naqi , Kainat Faizan , Fayaz Chandio , Aadil Ameer Ali , Shoaib Waqas , Suhani Bhatti , Aiman Bachani
Published: September 2021

Objective: To Compare the Level of Mental Stress among Exercising and Non-Exercising under graduate Physiotherapy Students of LUMHS, Jamshoro. Methodology: A cross sectional survey was conducted from October to December 2019, and the data was collected from the undergraduates students of Institute of Physiotherapy & Rehabilitation Sciences, Liaquat University of Medical and Health Science Jamshoro, Pakistan. The Perceived Stress Scale (PSS) was used among 194 undergraduate physiotherapy students. Apart from the demographics (age, gender, education & locality) the PSS questionnaire consist of 10 questions. The Statistical Package for Social Sciences (SPSS) version 22 was used to interpret the data. Result: The majority (n=101, 51.7%) were from the age group of 18 to 21 years and (n=127, 65.1%) were female. Mostly (n=49, 25.1%) were the students of 1st year Doctor of Physical Therapy and (n=116, 59.4%) of the students were the residents of urban area. Among the non-exercising group of students majority (n=66,68%) were suffering from low level of mental stress, (n=33,34%) were suffering from moderate level of mental stress and (n=24,24.7%) were suffering from severe level of mental stress followed by the exercise group, in which (n=40,41.2%) were suffering from low level of mental stress, (n=21,21.6%) were suffering from moderate level of mental stress and (n=10,10.%) were suffering from severe level of mental stress. Conclusion: The study finalized that the exercising group of students had lower level of mental stress as compare to the non-exercising group of students. However both groups have the individuals with mental stress but the exercising students group had low number of those individuals.
Chemical Compounds and Biological Activity of Turkish Santolina chamaecyparissus L. Essential Oil by Microwave Assisted Distillation
Authors: SÜFER Özge , CEYLAN Ahmet , ONBAŞILI Dilşad , ÇELİK YUVALI Gökçen , BOZOK Fuat
Published: September 2021

Aim of study: The essential oil of S. chamaecyparissus (SEO) was isolated by microwave assisted distillation system to analyze the antioxidant and antimicrobial activities.

Area of study: S. chamaecyparissus were collected from Osmaniye province of Turkey in April 2018.

Material and method: The chemical constituents and groups (by GC/MS and FTIR spectroscopy, respectively), antioxidant (by DPPH technique) and antimicrobial activities (by agar disc diffusion method) of SEO were investigated.

Main results: Twenty aromatic compounds were determined and artemisia ketone (39.83%), camphor (17.65%), β-phellandrene (8.03%) and β-bisabolene (7.32%) were the most abundant. IC50 values which were the indicators of antioxidant behavior of SEO, butylated hydroxytoluene (BHT) and gallic acid recorded as 88.301, 0.212 and 0.021 g/L respectively. The antimicrobial activity results showed that all tested microorganisms (Escherichia coli, Streptococcus mutans, Bacillus cereus, Bacillus subtilis, Candida albicans) were highly inhibited.

Highlights: SEO could be a good source of monoterpenes especially artemisia ketone. Its herbaceous fragrance may provide a new usage area in men’s perfumery.
Çocuğun İyi Olma Hâlinin Gelişmesinde Sosyoekonomik ve Yönetsel Politikalar: Finlandiya Örneği
Authors: KURBAN Samed
Published: September 2021

Son yıllarda, çocuğun iyi olma hâline odaklanan politikaların daha bütüncül bir yaklaşımla ele alındığı görülmektedir. Bunun sebebi sadece eğitim, sağlık ya da maddi yaşam koşullarına vurgu yapan sosyal refah politikalarını uygulamanın tek başına yeterli olamayacağıdır. Çünkü çocuğun iyi olma hâli çocukların bugünkü yaşamları yanında geleceklerine ilişkin durumu da içine almaktadır. Dolayısıyla, politika yapıcıların tek taraflı bir iradenin sonucu olarak uyguladığı politikalar, beşerî ve maddi kaynaklardan yeterince faydalanılamamasına yol açacaktır. Çocuğun iyi olma hâli, doğru politikaların ve yeterli düzeyde kaynak kullanımının sonucunda gençler ve yetişkinler için olumlu dışsallıklar ortaya çıkarmaktadır. Bunun için çocuklara yönelik gerek toplumsal gerekse ekonomik açıdan birtakım amaçların yönlendirilmesine ihtiyaç duyulmaktadır. Finlandiya, çocukların nesnel yaşam koşullarının ve öznel değerlendirmelerinin gelişimini olumlu yönde etkileyen yaklaşımlara sahiptir. Eğitim, sağlık, sosyal refah hizmetleri gibi temel alanlarda çocuklara yönelik uygulanan politikalar, kamunun belirleyiciliğinin başarısını ortaya koymaktadır. Temel kamu hizmetlerine ilişkin uygulanan politikalar yanında çocukların kendilerini ifade edebilmelerine imkân tanınmaktadır. Çalışma, sosyal refah hizmetleri ve yönetsel politikalar üzerinden Finlandiya’da çocuğun iyi olma hâline odaklanmaktadır. Bu bağlamda, çocuklar için daha kaliteli bir yaşamın oluşturulması sürecinde devletin üzerine düşen sorumluluğun önemi irdelenmektedir.
The Legal Nature and the Place of the Right to Disconnect in European and in Russian Labour Law
Authors: Chesalina Olga
Published: September 2021

The first part of this article is devoted to the legislative proposal for a Directive of the European Parliament and the Council on the right to disconnect that was adopted on 21 January 2021 in the European Parliament Resolution. In this part of the article the legal nature of the “right to disconnect, “the personal and material scope of this right as well as the relationship to other (fundamental) labour rights and different aspects of the employment relationship are analysed. Furthermore, the author discloses the gaps of the legislative proposal and makes some suggestions concerning a new concept of working conditions. The second part of the article focuses on Russian labour law. During the process of reforming the legislation on remote work it was widely discussed whether “a right to disconnect” should be provided for in the Russian Labour Code. The author analyses problems with the organisation of working time concerning the application of a special working regime entitled “unregular working day” and the recording of working time. Furthermore, the perspectives of the application of self-protection of labour rights as a way to guarantee the right to disconnect are examined. The conclusion stresses which measures would be necessary for an effective execution and enforcement of the right to disconnect.
Presumption of Consent or a Lack Thereof of the Victim and the Presumption of Guilt (Innocence) of the Accused in Cases of Sexual Offences: Emphasise What Is Necessary, Cross Out Everything Unnecessary
Authors: Besedin Gleb , Stepanov Pavel
Published: September 2021

The article focuses on the significance and relevance of victims consent in sexual offenses cases. The case-law of national legal systems as well as of international judicial bodies demonstrates that consent is a conditio sine qua non for qualifying an act as a sexual offense. However, the recent examples of criminal cases raised from national and international jurisprudence allow authors to conclude that the non-consensual character of sexual acts is frequently complicated to prove in due to some peculiarities of the sexual offenses per se. This paper analyses the modern technique of sexual offenses criminalization which can be characterized by one of two possible approaches: first, the presumption of the alleged victim’s consent to sexual intercourse or, on the contrary, second, the presumption of the lack of thereof. Despite the fact that the second approach seems to be more favorable for alleged survivors, the implementation of this approach entails a number of difficulties. The main one is the hypothetical conflict with the metapresumption of criminal procedure (i.e. the presumption of innocence). In the paper this contradiction is analyzed from the perspective of the legislation and jurisprudence of different jurisdictions, as well as the practice of international judicial bodies (European Court of Human Rights, International Criminal Tribunal for the former Yugoslavia, International Criminal Tribunal for Rwanda).
Legal Mechanisms to Regulate Civil Liability for Actions of Artificial Intelligence in the Russian Federation and European Union Law
Authors: Kondrateva Ksenya , Nikitin Timur
Published: September 2021

In this article authors discuss existing ideas about liability of artificial intelligence based on guilty and strict approaches to defining the elements of civil liability in the Russian Federation and European Union. These approaches have drawbacks, which are, first of all, in the excessive limitation of the development of innovations, and with low efficiency in achieving the goals of civil legal responsibility and the implementation of its functions. The risk-based approach proposed by the author to the determination of the elements of civil liability for the actions of artificial intelligence is intended to neutralize the named drawbacks. Based on the analysis of the spheres of application and artificial intelligence technology, the risk-based approach allows a more efficient and flexible approach to the definition of the subject of responsibility, its types and limits, ensuring a balance between the development of innovation and the goals of civil liability. As a result of the study, the author’s definition of a risk-based approach to civil liability for the actions of artificial intelligence has been given, its features, elements have been disclosed, and its advantages over existing approaches to civil liability have been demonstrated.
Local Legislative Process in Russia: Perspectives and Barriers
Authors: Mamontova Victoria , Gladun Elena
Published: September 2021

The legislative process is an important tool of direct democracy for creating checks and balances on public authority. Making local laws is an essential function of the local government that is linked to direct communication between public officials and citizens. This paper sets out to evaluate the opportunities, constraints and challenges in the practices of local direct democracy in Russian municipalities, and to describe the frameworks and capacities that municipal authorities provide for citizens. The paper analyzes the political and legal circumstances for law-making initiatives at the local level and examines citizens’ activities in the local legislative process. The research question is whether citizens have the capacity and opportunity to participate in the local legislative process and to what extent barriers and challenges prevent them from doing so. To answer the research question the authors use methods of context analysis to study Russian legislation and municipal legal documents, a case study of several Russian municipalities and a survey with representatives of local communities in Tyumen, a Russian mid-sized city located in Western Siberia. The results of the study show a reluctance on the part of local residents to engage in the various aspects of direct democracy and a lack of the necessary skills, knowledge and willingness to participate in the initiative process. The results further show that the initiative process is frequently not well planned and lacks clear objectives, requirements and guidelines. The study concludes that seminars and professional training as well as roundtable workshops are effective ways to support local law-making initiatives. One promising step towards modernizing initiatives would be to organize them in e-forms. Many citizens demonstrate their ability to use electronic options that can expand the possibilities for their participation in the local legislative process.
CONDITIONS FOR THE COINCIDENCE OF THE LS AND AITKEN ESTIMATIONS OF THE HIGHER COEFFICIENT OF THE QUADRATIC REGRESSION MODEL
Authors: Savkina Marta
Published: September 2021

In the paper in the case of heteroscedastic independent deviations a regression model whose function has the form $ f (x) = ax^2 + bx + c$, where $a$, $b$, and $c$ are unknown parameters, is studied. Approximate values (observations) of functions $f (x)$ are registered at equidistant points of a line segment. The theorem proved in the paper states that Aitken estimation of the higher coefficient of the quadratic model in the case of odd the number of observation points coincides with its estimation of LS iff values of the variances satisfy a certain system of nonlinear equations. Under these conditions, the Aitken and LS estimations of $b$ and $c$ will not coincide. The application of the theorem for some cases of a specific quantity of observation points and the same values of the variances at nodes symmetric about the point $\frac{1}{2}$ is considered. In all these cases it is obtained that the LS estimation will be coincide Aitken estimation if the variance in two points accepts arbitrary values, and at all others does certain values that are expressed through the values of variances in these two points.
Personalistic Analysis of Post-Traumatic Deformation of Conscious Processes
Authors: Krasilo A.I.
Published: September 2021

The article is devoted to the study of the sources and features of post-traumatic deformation of the conscious processes of victims from the perspective of a new direction in counseling — cultural and historical personalism. For this purpose, a psychological analysis of the social form of psychological trauma is undertaken, which allows us to explain the obsessive memories and post-traumatic reactivity of the victims as their own, but objectified and alienated, neurotic activity in the sphere of kaleidoscopic consciousness. This neurotic activity also has an existential side: the victim seeks to free himself from the psychological power of the participant in the traumatic situation, on whom he pro-jects all the blame for the pain of his experiences.
Psychological Determinants of Young People's Attitudes towards Extremist Activity
Authors: Kuznetsova A.S. , Khavylo A.V.
Published: September 2021

The article is dedicated to the study of psychological determinants of young people's intolerant behavior towards individuals of other cultures and ethnic groups as a prerequisite to one's inclination to extremist activity. Theoretical analysis revealed that a tendency towards extremist activity is formed from cognitive and behavioral manifestations such as low awareness of the problem of extremism, rejection of other values and cultures, negative attitudes towards other ethnic groups and difficulties in determining legitimacy of one's actions. The empirical study was conducted on a sample of young people from Kaluga aged 18-25. The Volitional Control Questionnaire, the Big Five Personality Inventory and a specially developed questionnaire have been used. It has been established that a large part of the youth is informed about the manifestations of extremism but isn't fully aware of the severity of such crimes. A link between behavioral and cognitive manifestations related to extremism with certain personality determinants such as high sensitivity, inadequate self-assessment, insufficient maturity of outlook-related attitudes, lack of goodwill and rigidity of opinions is demonstrated.
Indicators of Pre-Suicidal State of Minors in the Internet Space
Authors: Ponomareva E.S. , Delibalt V.V.
Published: September 2021

The article aims to describe potential indicators of pre-suicidal state of minors manifesting in online-behavior that were revealed in the empirical study which involved 43 respondents aged 13-15 (M=14.19). The subjects for the study were selected among the teenagers who had responded to our advertisement messages published in various groups on the VKontakte social network. The following methodologies were used: UCLA Loneliness Scale (version 3) (D. Russell, L. A. Peplau, M. Ferguson); Beck Hopelessness Inventory; WHO-5 Well-being Index (1998); Cognitive Errors in Online Communication (I.S. Luchinkina); Sentence Completion for Events from the Past Test (SCEPT) (F.Raes et al.); Individual Typological Child Questionnaire (L.N. Sobchik). The data obtained lead to conclude about the characteristics of the profile related to presence of a distinct pre-suicidal condition: a tendency towards increase in the proportion between the number of subscriptions where suicide is mentioned (including those associated with corresponding emotions, as well communities collecting suicide-related art) and the total number of subscriptions. The number of comments on one's page is inversely proportional to the severity of one's pre-suicidal condition.
Aspects of Emotional Maturity Manifestation in Female Convicts Serving Deprivation of Liberty Sentences
Authors: Pozdnyakov V.M. , Kalashnikova T.V. , Ovsyannikova M.V. , Kalashnikova M.M.
Published: September 2021

This article presents theoretical and methodological basis for studying the phenomena of emotional intelligence and emotional maturity in foreign and Russian psychology including the status of research done by prison psychologists. The article also provides data of our research on determination and psychodynamics of emotional intelligence, as well as transformation of other personality characteristics in 220 female convicts at various stages of serving their sentence in penal correction colonies in five regions of Russia. The findings of the psychodiagnostics indicate insufficient levels of emotional intelligence and reveals the prison-specific subcultural manifestation of its components in the examined inmates, who at the same time possess underdeveloped compensatory personality resources. Cluster analysis made it possible to isolate the predominant types of convicted women: "emotionally impulsive" and "emotionally rigid" whose contrasting psychological characteristics must be taken into account when developing individual correctional and group-related correctional and developmental programs. In order to improve female convicts' emotional maturity, a series of measures of legal-institutional and correction- and development-related character has been substantiated.
Trubnikov G.A. Chronic bronchitis in conditions of ecological disadvantage. - Astrakhan, Astrakhan State Medical Academy Press, 1996, 180 p.
Authors: Bogoyavlensky V. F.
Published: September 2021

The monograph of Professor G.A. Trubnikov, Astrakhan Medical Academy, as well as his act speech, which was pronounced at the ceremonial meeting of the Academy on 20.11.1996 on the occasion of the 78th anniversary of the famous medical institution, reveals the basis of the new direction of the clinic of internal diseases - pulmonology ecology.
International Symposium "Current Views on Hypertension"
Authors: Latfullin I. A.
Published: September 2021

Prof. R.G. Oganov, Director of the Center for Preventive Medicine, RF Ministry of Health (Moscow), touched upon epidemiological aspects of hypertension. High prevalence of arterial hypertension (AH) was found among men and women, and it increases with age, reaching 20-25% by the age of 50. Long-term prospective observations have shown that AH depends on age, body weight and alcohol consumption.
Hypertensive disorders in pregnancy at the federal medical centre, Yenagoa, South-South Nigeria: a 5 year review
Authors: Oriji Peter Chibuzor , Allagoa Dennis Oju , Ubom Akaninyene Eseme , Kattey Amos Kattey , Briggs Datonye Christopher , Chika Maduabuchi Nduaguba , Iloeje Ugoeze Nneka , Akanatei Inere Daniel , Atemie Gordon
Published: September 2021

Background: Hypertensive disorders complicate 5.2%-8.2% of pregnancies, and contribute significantly to perinatal and maternal morbidity and mortality worldwide. To determine the incidence, clinical characteristics, maternal and perinatal outcomes of hypertensive disorders in pregnancy at the Federal medical centre, Yenagoa, Bayelsa State, South-South Nigeria.Methods: This retrospective study was conducted between 1 January, 2016 and 31 December, 2020. Relevant data was retrieved, entered into a pre-designed proforma, and analysed using IBM SPSS version 25.0.Results: Out of the 4,571 obstetric patients that were managed in our Centre in the period under review, 335 of them had HDP, giving an incidence rate of 7.32%.The most common HDP were pre-eclampsia (189, 56.4%) and eclampsia (82, 24.5%), while the least common was chronic hypertension (3, 0.9%). A little more than one-half (171, 51.0%) of the women delivered preterm, with a mean gestational age at delivery of 35.5 weeks. The most common route of delivery was emergency Caesarean section (205, 61.2%). There were three maternal deaths, giving a case fatality rate of 0.9%. Two of the maternal deaths were due to eclampsia, and one, from pre-eclampsia.Conclusions: Women should be adequately counseled to embrace preconception care, and early and regular antenatal care visits, with proper monitoring of blood pressure and urine protein. Prompt diagnosis and management are key in preventing the maternal and perinatal morbidity and mortality that are associated with these disorders.