bluuebunny/crossref_metadata_2025 huggingface dataset:
The roles of ROS and P21 in apoptosis-inducing effect of cepharanthine in human colorectal cancer cells
Authors:   , Saetung Rattana
Published: April 2023

Cepharanthine (CEP), a natural compound isolated from Stephania cepharantha Hayata, has been shown to possess anti-cancer activity against several cancers including colorectal cancer (CRC) cells. Previously, it was found that cytotoxicity of CEP was associated with ROS generation and p21Waf1/Cip1 expression. However, information regarding to the molecular mechanisms underlying the apoptosis-inducing effects of CEP in CRC cells is still limited. Therefore, the present study aimed to evaluate the roles of ROS and p21Waf1/Cip1 in the apoptosis-inducing effect of CEP in two human colorectal cancer cells lines, p53 wild-type HCT116 cells and p53 mutant HT-29 cells. The results demonstrated that CEP significantly inhibited the growth of both HT-29 and HCT116 cells. Remarkably, CEP was more effective than L-OHP in controlling the growth of HT-29 cells. Moreover, CEP induced apoptosis was mediated through upregulation of pro-apoptotic Bak, downregulation of anti-apoptosis Bcl-xL, and induction of poly (ADP-ribose) polymerase (PARP) cleavage in both HT-29 cells and HCT116 cells. Additionally, CEP was found to induce ROS generation in HT-29 and HCT-116 cells. It should be noted that N-acetyl cysteine (NAC) could abolish the apoptosis-inducing effects of CEP in both HT-29 cells and HCT116 cells, suggesting that CEP-induced apoptosis is mediated through ROS generation. Furthermore, CEP could modulate ERK1/2 signaling pathway by inhibiting ERK1/2 phosphorylation in HT-29 cells while activating ERK1/2 phosphorylation in HCT116 cells, which was found to be associated with ROS generation. Notably, CEP markedly upregulated the expression of p21Waf1/Cip1 in p53 mutant HT-29 cells but did not alter the expression of p21Waf1/Cip1 in HCT116 cells. A p21 inhibitor, UC2288, could abolish apoptosis-inducing effect of CEP in HT-29 cells, suggesting that CEP-induced apoptosis is mediated via upregulation of p21Waf1/Cip1 in p53 mutant HT-29 cells. Taken together, the results of this study demonstrated that generation of ROS and upregulation of p21 Waf1/Cip1 play a significant role in apoptosis-inducing effect of CEP in p53 mutant CRC cells.  It may be useful for treatment of colorectal cancer carrying mutant p53 which often cause resistant to current chemotherapeutic agents.
Effects of prenatal methamphetamine exposure on learning and memory and synaptogenesis in mouse hippocampus
Authors:   , Benya-aphikul Hattaya
Published: April 2023

The dynamic processes of brain development during perinatal period are vulnerable to neurotoxic insults leading to changes in brain structure and functions. Hippocampus plays an important role in learning and memory. Hippocampal formation can be influenced by substance used during brain developmental processes including neuron differentiation and synaptogenesis.  Brain-derived neurotrophic factor (BDNF) regulates neuron development and neuroplasticity via its receptor TrkB. Methamphetamine (MA) abused and the risk of MA exposed during pregnancy have increased recently. The present study aimed to elucidate the effects of prenatal MA exposure on learning and memory. Prenatal effects of MA on neuronal morphology and synaptogenesis, and the underlying neurotoxic mechanism involving BDNF-TrkB signaling pathway were also determined. Pregnant C57BL/6JNc mice were treated with either MA (5 mg/kg, s.c.) or normal saline on gestation day (GD) 8-15. Primary hippocampal cultures were prepared from embryos at GD16.5. Hippocampal neurons were used to examine morphology of axons and dendrites, synaptogenesis and BDNF-TrkB signaling protein expression. For in vivo study, adolescent (6 weeks old) and adult mice (12 weeks old) were conducted behavioral studies in open-field test, novel object recognition (NOR), novel location test (NLT), elevated plus maze (EPM) and forced swimming test (FST).  Brains from prenatal day 14 (PND14), adolescent and adult mice were collected to determine presynaptic (synapsin-I), post-synaptic (PSD-95), and BDNF-TrkB signaling protein expression. Prenatal MA exposure impaired NLT performance in female adolescent mice while MA-exposed male adolescent mice showed memory deficit in NOR test. Moreover, prenatal MA exposure caused memory impairments in NOR and NLT in female and male adult mice. However, there were no effects on locomotor activity, anxiety and depression levels. MA-exposed hippocampal primary culture demonstrated decreases in secondary dendritic branches, axonal length and diameter. The number of presynaptic terminals and co-localization between pre- and postsynapse in MA group were also declined. The expression levels of presynaptic protein were decreased in the hippocampus of MA-exposed PND14 mice, but an increase in postsynaptic protein expression levels were presented in adolescent and adult mice. Prenatal MA exposure reduced TrkB expressions in primary cultures, while the expression levels of BDNF-TrkB signaling proteins in hippocampal tissue were not changed.  The increased BDNF expression was observed in the prefrontal cortex and striatum of MA-exposed PND14 mice. This study showed the long-lasting effects of prenatal MA exposure on learning and memory impairments in adolescent and adult mice. These effects resulted from the disruptions of hippocampal neuronal growth and synaptogenesis in the developing brain. Alterations of BDNF-TrkB signaling and presynaptic proteins were found in early age, which lead to an adaptation in postsynaptic proteins.
Effect of social media model to improve sexual health literacy among secondary school female students in southern provinces, Thailand: a quasi experimental study
Authors:   , Narkarat Premyuda
Published: April 2023

Background/Objectives: Adolescent pregnancy is one of major public health issues globally and in Thailand. Female adolescents are at high risk of sexual and reproductive health problems like unintended pregnancies, abortion, childbirth related complications including sexually transmitted diseases (STDs) and AIDS due to poor sexual health literacy (SHL). Sexual health literacy (SHL) is one of very important factors to prevent teenage pregnancy. The aim was to examine the effect of social media model to improve sexual health literacy among secondary school female students in southern provinces of Thailand.

Method: This study employed a quasi-experimental research design using two groups the intervention and the control groups. The total number of 128 participants were participated in the study. 64 participants were placed in the intervention group and the control group equally. The study ran for 24-week with 4 serial measurements (0, 8, 16, 24 weeks of intervention). The intervention group received health education through social media model to improve sexual health literacy, while the control group attended regular school classes only and received neither social media model on sexual literacy. The sexual health literacy questionnaire composed of four elements including 1) accessing information, 2) understanding information, 3) appraising information and 4) applying/practicing. A self-administered questionnaire was used. Descriptive statistics including frequency, percentage, mean, and standard deviation (SD) were used to describe the socio-demographic characteristics; pair t-test, independent t-test, and One-Way ANOVA Repeated Measurement were used for data analysis.

Result: The baseline characteristics of both groups were similar. After the intervention program, the mean scores of both groups started to change in the week 8, 16 and 24. The mean scores of participants in the intervention groups had increased from the week 8, 16 and 24 respectively with statistically significant at the .05 level (F = 489.82, p = 0.00), while the mean scores of participants in the control group did not change much with statistically significant at the .05 level (F = 10.72, p = 0.00). In term of level of sexual health literacy, the scores among female students in the intervention group were sufficient (76.56%), whereas the scores of female students in the control group were inadequate (100%).  After the intervention program, the scores in the intervention group showed higher level distribution of the sexual health literacy scores more than the control group.

Conclusion:  Social media model has improved sexual health literacy (SHL) among secondary school female students.
Ismail Efendi Ndroqi - Një jetë në shërbim të pavarësisë së atdheut dhe edukimit shpirtëror të brezave
Authors: Ndroqi Dr. Zamir
Published: April 2023

Datat 28 nëntor 1912 dhe 11 shkurt 1920 janë ndër datat më kulmore në historinë tonë kombëtare të këtyre 110 viteve të fundit. Patriotët, njerëzit e përparuar, të shkolluar e të aftë që u vunë në drejtim të Shqipërisë dhe të kryeqytetit, ishin vizionarë. Ata kishin studiuar dhe jetuar në vende të përparuara dhe dëshironin që edhe Shqipëria jonë të kishte fytyrën e një vendi të përparuar, të lirë e më vete.

Familja Ndroqi, që nga stërgjyshi ynë, Aliu, shquhej në Tiranë si familje bamirëse dhe derë nacionalistësh, me veprimtari patriotike, ku shquhen tre vëllezërit: Ibrahimi, figurë e ndritur e shqiptarizmës në Tiranën e asaj kohe që kishte titullin “Myderriz” (profesor), Ismaili dhe Mehmeti, vëllai i tretë, ishte patriot i shquar, pjesëmarrës në lëvizjet përparimtare në fillimshekullin XX, i cili ngriti shtypshkronjën “Gutenberg”, e para në Tiranë, që përhapte librin, dijen e kulturën. Ismail Ndroqi është figura më e spikatur e familjes në këto periudha, shumë aktiv në jetën politike, qytetare e shpirtërore (fetare).

Ismaili u bë një nga figurat kryesore të lëvizjes kombëtare kundër pushtuesve osmanë dhe shovinistëve fqinjë, të cilët punonin për copëtimin e Shqipërisë.
Trokitje në dyert e dijes
Authors: Kona Viron
Published: April 2023

Në këtë artikull do të trajtojmë rolin e madh që ka mësuesit në edukimi e nxënësve në shkolla, si dhe nxitja e ideve, dëshirave, pasioneve dhe ëndrrave të nxënësve për jetën, për zhvillimet, shkencat, kulturën, artin etj.

Nxënësit, dëshirojnë, kërkojnë vetveten, përpiqen të gjejnë forma, të debatojnë e të paraqesin idetë, ambiciet, mendimet ashtu siç i ndjejnë dhe siç e kuptojnë jetën. Ata dëshirojnë jo vetëm të hedhin në letër dhe të botojnë pjesë në prozë apo vargjet e tyre poetike, por duan edhe të provojnë, të konkurrojnë, të tregojnë se edhe ata mund të bëhen gazetarë, të zbulojnë lajmin, të japin informacionin, të debatojnë dhe të hedhin në tavolinë ide dhe alternativa, të provojnë veten “sa vlejnë” si poetë, shkrimtarë, piktorë e skulptorë, si historianë e gjeografë, të thellojnë dijet e tyre në kimi, biologji, fizikë…, të dinë sa më shumë për kozmosin, të nxiten nga dëshira për aventura për të zbuluar enigmat dhe misteret e gjithësisë, pra, u pëlqen të shprehen me kurajë, duke u dhënë krahë ëndrrave, fantazisë, imagjinatës, dëshirës për të formuar personalitetin, për t`u bërë edhe ata dikush në jetë, të tregojnë prirjet e tyre progresive në rrugët e gjera të dijes.

Në artikull do të sjellim si shembull një almanak me krijime i nxënësve të një shkolle të mesme të bashkuar në fshatin Shalës të Elbasanit dhe tregohet se si mësuesi i tyre, ka ditur të nxisë dhe të organizojë dëshirën dhe mendimet poetike dhe krijimet në prozë të nxënësve. Mësuesi i kishte mbledhur së bashku me ta, siç mblidhen nga kopshti lulet e bukura dhe të freskëta në një buqetë dhe ishte kujdesur që ato të botoheshin në një libër të veçantë, duke vlerësuar arritjet e nxënësve, por edhe duke u kujdesur që talenti i tyre të zhvillohej përherë e më shumë. Çelësat e dyerve të dijeve, ua japin fëmijëve dhe nxënësve adoleshentë mësuesit e tyre, më të mirët, më të dashurit për ta, që i duan dhe i ndihmojnë. Këta mësues dinë se si t`ua bëjnë më të lehta gjërat më të vështira, se si ata të motivojnë sa më mirë vetveten, sesi t`u ngjallen shpresat dhe besimin se jeta është e bukur, por për ta jetuar atë, duhet punuar e luftuar vazhdimisht, duhet guxuar.
Procesi i komunikimit te fëmijët nga mosha 0-5 vjeç
Authors: Simo Marsi
Published: April 2023

Në moshën 1-vjeçare te fëmijët fillojnë të zhvillohen aftësitë metalinguistike, të cilat lidhen me aftësinë për të menduar dhe përdorur gjuhën. Diku pas moshës 2-vjeçare, të vegjlit mund të imitojnë ose përdorin zëra të ndryshëm sipas kërkesave që kanë. Ndërsa pas moshës 4-vjeçare, kanë mundësi të identifikojnë dhe të përdorin gjuhën trupore. Në vijim të viteve këto aftësi vijnë duke u përmirësuar. Fëmija nis një diskutim duke shprehur një mendim, por nuk duhet të harrojmë që ky mendim nuk ka ardhur nga hiçi. Ai është formuar nga mësimet e marra nga prindërit, shkolla, librat, apo mënyra të tjera të edukimit informal. Ndryshe nga të rriturit, të vegjlit nuk janë të pajisur me filtra për të nisur komunikimin dhe nuk e mendojnë gjatë, nëse duhet apo jo të komunikojnë, apo a është momenti i duhur për këtë komunikim. Ata nxiten nga kurioziteti dhe dëshira për të mësuar më shumë rreth botës që i rrethon.
Gjithashtu duhet theksuar rëndësia e komunikimit që përdor prindi ndaj fëmijës, jo vetëm si përcjellës informacioni dhe domosdoshmëri për ta aftësuar në mënyrë të pavarur, por edhe për ta formësuar të voglin me cilësi më të mira kryesisht në ato ndërpersonale. Nëse aftësia e inteligjencës (IQ) është paracaktuar në mënyrë gjenetike dhe nuk mund të ndryshojë me përvojën e jetës dhe se fati ynë në të shumtën e rasteve është i caktuar me këtë lloj dhurate, ajo që mund të përpunojnë prindërit është inteligjenca emocionale. Kjo inteligjencë ndërtohet hap pas hapi me metoda efikase të cilat janë aty pranë, që nga përrallat e thjeshta, deri te lodrat dhe lojërat që mund të krijohen nga prindi. Baza e kësaj inteligjence ështe empatia, apo aftësia për të kuptuar se çfarë ndjen tjetri.
Një analizë e ahengut dhe ndërthurjes së elementeve të kulturës tradicionale shqiptare me atë osmane
Authors: Bizhga Denis
Published: April 2023

Meloditë e muzikës qytetare të Shkodrës përmbajnë elemente të muzikës profesionale shqiptare. Stili muzikor i Shkodrës është krijuar në një qytet të madh me ndikim ekonomik, social dhe kulturor për shumë vite. Ai ka një nivel të lartë të sofistikimit të melodisë “arioso”, si rrjedhojë e performancës së hollësishme instrumentale.
Instrumentet në muzikën shkodrane luhen me një shkathtësi të madhe. Formacionet muzikore instrumentale, si bandat frymore dhe koret, patën një zhvillim të madh përgjatë gjysmës së dytë të shekullit XIX dhe të shekullit XX. Në varësi të këngëtarit dhe të periudhës kohore, vokali gjithashtu mund të përmbajë ndikime nga elemente të tjera muzikore. Kënga qytetare shkodrane gëzon një repertor të pasur dhe të larmishëm. E lindur në ambient me rrethana të caktuara historike, muzika qytetare ka fituar tipare të përcaktuara në interpretimin e saj muzikor. Për shembull, këngëtari i gjysmës së dytë të shekullit XX, Bik Ndoja, shpesh tingëllon plotësisht si një tenor i zhanrit klasik që interpreton këngë tradicionale shqiptare.
Instrumentet më të përdorura në stilin muzikor qytetar të Shkodrës përfshijnë klarinetën, violinën, kontrabasin, llautën, kitarën akustike, fizarmonikën, pianon dhe tamburin. Në muzikën shkodrane, asnjë instrument nuk ka fituar përparësi mbi të tjerët, përkundrazi meloditë kanë tendencë të shfaqen si një përzierje që përfshin në menyre të barabartë të gjitha instrumentet. Sidoqoftë, ka këngë që kanë tipare të dallueshme, ndonjëherë në formën e solos së një instrumenti të veçantë. Në këngët e muzikës qytetare shkodrane bëjnë pjesë ato të ceremonialit të dasmës dhe ahengu qytetar. Shumica e këngëve shkodrane i përmbahen një modeli të paracaktuar.
Onomastika në veprën e Thimi Mitkos
Authors: Krasniqi Faton
Published: April 2023

Onomastika e folklorit në veprën e Thimi Mitkos është një nga pjesët më të rëndësishme dhe njëherazi, shumë e pasur me emra të përveçëm vendesh e njerëzish, toponime e antroponime që janë pasqyruar në veprën e tij. Në veprën e Thimi Mitkos, përpos onomastikës, gjenden elemente logjike, etike, psikologjike, fizike e metafizike.

 Në lidhje me këtë, Thimi Mitko sjell citate për të mbështetur mendimet, duke përmendur emra autorësh e vendesh në shkrime të ndryshme. Onomastikën e veprës së Thimi Mitkos do ta paraqes në formë fjalori, sipas rendit alfabetik, në mënyrë që lexuesi apo studiuesi, duke i parë të renditura, ta ketë më të lehtë kërkimin dhe gjetjen e elementeve onomastike, që i duhen për t`i njohur ose për t`i studiuar. Në këtë shkrim do të trajtojmë onomastikën (emra të përveçëm vendesh e njerëzish- toponime e antroponime) që janë pasqyruar në veprën e Thimi Mitkos. Këta emra vetjakë (personalë) me vendet e tyre na njohin edhe me kulturën e Thimi Mitkos, natyrisht brenda rrethanave të kohës e të hapësirës së tij. Onomastika në veprën e Thimi Mitkos përmban emra të përveçëm, që i përkasin jo vetëm kohës së vjetër të Lindjes së Mesme, por edhe greqishtes së vjetër e latinishtes.

 Emrat e përmendur nga Thimi Mitko, kanë interes gjuhësor për t’u renditur, sepse në një mënyrë a në një tjetër krijojnë mundësi që të bëhen vrojtime të ndryshme, ndër të cilat edhe vrojtime gjuhësore për nga përshtatja fonetike e tyre në gjuhën shqipe, për nga burimi e të tjera si këto. Një pjesë e onomastikës përmbledh toponime e antroponime, që lidhen me vetë Thimi Mitkon dhe veprën e tij ose me vendin, popullin e gjuhën tonë, çka merret si dokumentim edhe nga ana historike.
Disa mendime dhe konsiderata mbi veprën e Averroesit
Authors: Kafilaj Melsen
Published: April 2023

Averroes megjithëse nuk është i pari që kërkon të bëjë një pajtim midis filozofisë dhe fesë, ai ka meritë për faktin se i jep një rol qendror intelektit dhe arsyetimit demonstrativ, si një proces esencial, i cili na çon për tek e vërteta. Këtë mendim ai e shpreh edhe te traktati i mësipërm, kur pohon se studimi i filozofisë nuk është thjesht i lejueshëm, por i detyrueshëm (wajib).  Një sërë të vërtetash filozofike të dhëna në mënyrë alegorike gjenden edhe në Kuran. Ai synon ta pajtojë botëkuptimin aristotelian me atë fetar, duke argumentuar se edhe tezat e papajtueshmërisë që ngre teologu Asherit Al Gazali ndaj tyre janë të paqëndrueshme. Një temë qendrore e “Traktatit Vendimtar” është edhe ajo e interpretimit. Averroes rimerr debatin e vjetër të shekujve VIII-X, midis tradicionalistëve dhe racionalistëve, dhe e “përkthen” atë brenda kontekstit social-politik të Andaluzisë së tij, duke anuar dukshëm nga racionalistët. Duke qenë se shkrimet e shenjta i përmbajnë në vetvete të dyja kuptimet (të hapura dhe të fshehta) dhe vetë Kurani e lejon interpretimin, Averroes propozon që ky proces të bëhet nga njerëzit më kompetentë në këtë drejtim, të cilët e përdorin silogjizmin dhe janë të aftë në çështjet metafizike, pra, të bëhet nga filozofët, pasi argumenti filozofik është më i rëndësishëm sesa ai juridik. Është pikërisht ky pohim që i “xhindosi” klerikët, të cilët e nxitën kalifin ta dëbonte Averroesin nga Kordova dhe librat e tij të digjeshin. Duke filluar që nga viti 1999, për individët, organizatat e ndryshme, apo edhe për personalitetet politike, kulturore e shkencore që kontribuojnë për demokracinë dhe lirinë e shprehjes në botën arabe, jepet edhe çmimi prestigjioz Ibn Rrushdi “Për lirinë e mendimit”.
Tuzi përgjatë shekujve osmanë
Authors: Bardhi Ali , Kanaqi Dr. Behlul
Published: April 2023

Zona e Tuzit (ashtu si i gjithë rajoni përreth) dhe treva e Ulqinit, ku kemi bërë studime, bart vlera të jashtëzakonshme të një trashëgimie kulturore autoktone. E gjithë kjo hapësirë, ku rrjedhimisht bën pjesë edhe Tuzi, përgjatë historisë, i përket trashëgimisë kulturore autoktone të fisit ilir të labeatëve.

Në këtë rajon janë identifikuar edhe gjetjet e kulturës materiale të periudhave të mesjetës, kohës së re dhe asaj bashkëkohore, gjë që dëshmon për vazhdimësinë e jetës në trevën e komunës së Tuzit (Malësi) që nga parahistoria.

Nga literatura shohim se në shekullin XIV, Tuzi na paraqitet si emër fisi dhe vendbanimi. Për të parën herë, Tuzi, si një ngulim i vjetër që ndodhet karshi Podgoricës, i quajtur ndryshe edhe “Katuni” (Bashkësia e barinjve), përmendet në vitin 1330, në një kristobulë të Manastirit të Deçanit, kryetar i të cilit ishte Llesh Tuzi. Megjithëse Tuzi në dokumentet e shkruara për të parën herë ndeshet në vitin 1330, këto troje kanë qenë të banuara nga banorët autoktonë ilirë qindra vite para toponimit “Tuz, Tussis” apo ndonjëherë “Tushena (Tuscena)”. Kurse në vitet 1416-1417, Tuzin e shohim të ketë qenë një fshat që numëronte gjithsej 150 shtëpi.
DIGITAL DIDACTIC GAMES AS A MEANS OF REMOTE SUPPORT FOR SCHOOL STUDENTS
Authors: Popova L.
Published: April 2023

In the context of dynamic digitalization of the educational space, the introduction of inclusive education, the task of remote support for educational activities of both gifted students and schoolchildren with disabilities is of high relevance, since it helps to meet special educational needs and resolve difficulties in educational activities. The article presents an overview of some didactic games available for teachers and students on the platforms and services of the Internet and the relevant methodology, as well as a descriptive algorithm for self-development of such games for teachers. The goals, features and advantages of digital didactic games for the elimination of typical subject-­related and psychological difficulties in the educational activities among students of different ages are shown. The work expands the search base of research in the field of teacher education by analyzing the technology of using digital didactic games in the educational process of general and inclusive secondary education. Methodology and research methods. The study relies on general research methods of systematization and generalization, structural and functional analysis of the targeted use of digital didactic games to prevent and eliminate the difficulties experienced by schoolchildren in educational activities. The methodological basis of the research is a system-­activity approach, taking into account the age characteristics of students, as well as the development trends of the modern digital educational environment. Results and scientific novelty. The analysis determined the goals, functional purposes of digital didactic games used in the process of remote support for elementary school students, as well as for the secondary and high school. The author proposed an algorithm and recommendations for the game development and use of some existing templates for creating digital didactic games available to teachers on digital platforms and services on the Internet and suitable for remote elimination of educational difficulties at schoolchildren. Practical significance. The results obtained can be used by teachers of general secondary and inclusive education to implement remote support for schoolchildren at different levels of education.
SCREENING DIAGNOSTICS OF THE PSYCHO-EMOTIONAL STATE OF STUDENTS IN HIGHER EDUCATION SYSTEM
Authors: Agapov M.A. , Skalin Yu.E. , Bocharova N.N.
Published: April 2023

Positive emotional state of students in the system of higher education is one of the most important factors that contribute to good mental health, the development of educational programs and the prevention of aggressive and deviant behavior of students. One of the determining factors of whether or not young people will have mental health issues is the early detection of psycho-­­emotional disorders of students in order to develop an algorithm for appropriate psychological support. The study aims at assessing the possibilities and prospects of screening psychological diagnostics of university students remotely. The study was first conducted through the electronic learning management system (LMS). Psycho diagnostics revealed a significant level of anxiety in the examinees at the subclinical level of severity, certain dynamics of anxiety disorders and depression of students of different years of study, as well as manifestations of different forms of aggressive behavior. The received data allow to conclude that timely psychological online screening allows to provide early detection of psychological issues, develop an algorithm of actions and support intradepartmental and out-of-departmental interaction.
BABALARIN TRAVMATİK DOĞUM ALGILARI
Authors: BOYLU GÜLEK İmran , ÖZERDOĞAN Nebahat
Published: April 2023

Doğum, kadının hayatında güçlü psikolojik etkilere sahip önemli bir olay olarak kabul edilmekte ve doğum süreci her kadın ve ailesi tarafından içinde bulundukları kültürel özellikler doğrultusunda farklı deneyimlenmektedir. Bu süreçte özellikle ailenin iyilik halinin korunması için travmatik doğumla ilgili faktörlerin belirlenmesi ve sonuçlarının çözümlenmesi son derece önemlidir. Doğum anne için travmatik olabildiği gibi, anne veya bebeğin tehlikede olduğunu algıladığında baba için de potansiyel olarak travmatik yaşanabilmektedir. Ancak doğumda daha çok annenin yaşadığı deneyimlere odaklanılırken babanın ruh sağlığı göz ardı edilebilmektedir. Bu bağlamda yapılan derleme çalışmasının amacı, travmatik doğumla ilgili babaların deneyimlerini araştıran çalışmaları inceleyerek babaların doğumu travmatik olarak algılama nedenleri ve travmatik doğuma yaklaşımlarını ortaya koymaktır. Ayrıca doğumun babalar için nasıl daha az travmatik olabileceği ile ilgili uygulamaları sağlık profesyonellerinin rolleri çerçevesinde tartışmaktır.
Peran Mantin Organizer Sebagai Event Organizer Di Kota Palu
Authors: S Hendri , Samudra Suryadi , Kadang Juliana
Published: April 2023

Mantin organizer adalah perusahaan yeng bergerak di bidang event organizerdi kota palu. Perusahaan ini memiliki peran penting dalam menyelenggarakan berbagai jenis acara di kota palu, seperti pernikahan, gathering ,launching produk, dan acara perusahhan lainnya. Sebagai event organizer, matin organizer memastikan bahwa setiap acara yang di adakan memenihi kebutuhan dan harapan klien. Perusahaan ini mampu menyediakan layanan yang lengkap, mulai dari perencanaan, pelaksanaan, hingga evaluasi setiap acara yang diadakan. Matin organizerjuga memiliki tim yang  terampil dan berpengalaman  dalam mengelola  berbagai acara. mereka mampu bekerja dengan baik dalam situasi yang penuh tekanan dan mampu memberikan solusi yang tepat untuk setiap kendala yang muncul selama pelaksanaan acara. Dalam perkembanganya, matin organizer telah mampu menciptakan citra positif sebagai event organizer yang profesional dan terpecaya  di kota palu . hal itu dapat di lihat dari tinginya kepercayaan klien yang terus menggunakan jasa mantin organizer dalam setiap acara yang mereka selenggarakan dalam kesimpulannya, peran mantin organizer sebagai event organizer di kota palu sangat penting dalam menyelenggarakan  berbagai jenis acara  dengan standar yang tinggi. Dengan pengalaman dan keahlian yang di milikinya, mantin organizer telah membuktikan diri sebagai mitra yang handal dalam menyelegarakan  acara- acara di kota palu.
The first updated checklist of novel fungi in Pakistan (1947–2021)
Authors: Raza Mubashar , Cai Lei , Abbasi Muhammad Waseem , Hafeez Rahila , Tariq Marium , Kirk Paul M. , Hussain Muzammil , Wijayawardene Nalin N.
Published: April 2023

The role of fungi in both natural and managed ecosystem processes is unequivocal with mycotaxa being key drivers of soil, plant and animal health. Recent advances in DNA-based species identification and classification have enforced mycologists to update national checklists for proper exploitation of fungal traits and functions. However, in some countries like Pakistan, a comprehensive checklist of fungal diversity, distribution, and their host range is still lacking. Herein, we summarize novel fungal species (including both macro- and micro-fungi) for the first time from distinct geographical locations of Pakistan. A total of 742 novel fungal species in 7 phyla have been reported in Pakistan since 1947, including 136 ambiguous species (as a result of cryptic species, taxonomy revisions, and lack of DNA sequence data) and 113 species with DNA sequence data. The compilation of the fungal name list provides an overview of the currently known fungal taxa in Pakistan and enables the assessment of the knowledge gap on the fungal biodiversity in comparison to the rest of the world. The current checklist will serve as a foundation for new fungi names to be added in the future and can be used as a reference by mycologists to retrieve fungal species from existing culture banks in Pakistan mentioned on the website, www.fungiofpakistan.com, to exploit their functional traits in the food industry, health sectors and for sustainable agriculture in Pakistan.
A Color Book Laparoscopic Techniques in Small Animal Surgery
Authors:   ICAR Indian Veterinary Research Institute, Uttar Pradesh, India, Kumar Maiti Swapan , Kumar Naveen ,   ICAR Indian Veterinary Research Institute, Uttar Pradesh, India
Published: April 2023

This book covers most of the topics with updated information of modern diagnostic laparoscopy, laparoscopic surgery, laparoscopic guided organ biopsy and laparoscopic ancillary diagnostic techniques employed in small animal in a very concise from. The book is divided into twelve chapters covering all modern diagnostic and laparoscopic surgical techniques used in small animal practices. The main objective of the book is to provide the latest information to meet the requirements of not only undergraduate and postgraduate students but also to the teachers and veterinarians involved in laparoscopic diagnosis and surgery. The book contains more than 100 good quality colour photographs of laparoscopic diagnosis, laparoscopic surgery and laparoscopic ancillary techniques.
A Rare Case of Synchronous Uterine Leiomyosarcoma and Endometrial Endometrioid Adenocarcinoma
Authors: Neupane Samir , Tuladhar Sampurna , Koirala Srijana , Pariyar Jitendra
Published: April 2023

Assessment Synchronous primary neoplasms are defined when two or more neoplasms take place concurrently in the same patient. Concomitant endometrial adenocarcinoma and uterine leiomyosarcoma are extremely rare. Here we present an extremely rare case of uterine leiomyosarcoma coexisting with endometrial endometrioid adenocarcinoma of the uterus. A 52 years old woman was reported to a gynecology outpatient clinic with chief complaints lower abdominal pain, severe dysmenorrhea, and irregular vaginal bleeding for 7 months. Ultrasound of pelvis and abdomen showed a solitary intramural fibroid measuring 10x10cm. Surgery was planned and a simple total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed and specimen was sent to the laboratory for examination. Histopathological examination from intramural mass showed high-grade leiomyosarcoma, spindle cell type with less than 50% of myometrial invasion. Sections from thickened endometrium showed endometrial endometrioid adenocarcinoma, FIGO grade I with an invasion of superficial fascicles of myometrium (<50%). Morphological diagnosis was supported by Immunohistochemistry. Here we report an exceptionally rare case of synchronous uterine leiomyosarcoma and endometrial endometrioid adenocarcinoma. Our study may contribute to understand the prognosis of such multiple malignancies, common associations, and etiology of the disease so that a proper plan for further management of the patient can be implemented.
Estimation of Abnormal Findings in Screening Mammography: A Crosssectional Descriptive Study
Authors: Panta Pratibha , Benjankar Raj Babu , Sharma Pradip
Published: April 2023

Introduction: Breast cancer is the second leading cause of death in women of Nepal. Breast cancer awareness and clinical breast examination are the key steps for early detection of breast cancer in countries with limited resources like Nepal. Meanwhile, screening mammography can be used as a major tool to detect breast cancer at an early stage before development of signs such as lump. Screening mammography is very effective in detection of breast cancer. The aim of this study was to estimate the abnormal findings in screening mammography. Methods: Quantitative, cross-sectional, descriptive study was performed in the Department of Radiology and Imaging of Civil Service Hospital. Data was collected over a period of 6 months (April to September 2018) of female patients who visited for screening mammography were included in this study. Results: Out of total 90 female patients, in screening mammography, 42.22% were benign lesions like macro calcifications and cysts, while 57.78% were normal findings. There was no evidence of breast malignancy in the study group. Among the age group of 35-44 years 15.38 % had abnormal findings. Women undergoing screening mammography were mostly in the age group of 45-54 where 53.47 % of 43 women had abnormalities. Similarly only 10 out of 18 and 1 out of 3 had abnormalities in the age group of 55-64 and 65 and above respectively. Conclusion: The study concluded that the abnormal findings in females who visited for screening mammography were benign lesions i.e. calcifications and cysts
Olanzapine versus Aprepitant as Antiemetic in Highly Emetogenic Chemotherapy - A Randomized Clinical Trial
Authors: Sapkota Simit , Pandit Subhas , Mahaseth Rita
Published: April 2023

Introduction: Chemotherapy induced nausea and vomiting is still a major problem in highly emetogenic chemotherapy protocols. Current guidelines use neurokinin 1 inhibitors, 5-hydroxytryptamine 3 receptor antagonist (5HT3) antagonist and dexamethasone for its prevention. Use of olanzapine has been shown to be effective, safe as and cheap alternative to standard antiemetic protocol. The purpose of this study was to compare effect of Olanzapine on nausea and vomiting when compared to standard antiemetic protocol. Methods: Chemotherapy naive fifty patients receiving highly emetogenic chemotherapy were enrolled. 25 patients were randomly grouped on each arm. In arm A, tab aprepitant 125 mg, inj granisetron 1mg and tab dexamethasone 12 mg on day 1, tab aprepitant 80mg day 2 and day 3, tab dexamethasone 8mg day 2, day 3 and day 4 was given. In Arm B, patients received tab olanzapine 10mg, inj granisetron 1mg and tab dexamethasone 12 mg was given on day 1 and tab olanzapine 10mg PO and tab dexamethasone 8mg day 2, day 3 and day 4 was given. Results: Complete response was 88 % for acute period (24 hours post chemotherapy) and 76% for delayed period (2-5 days post chemotherapy) in Arm A and 84 % for acute period and 72% for delayed period in Arm B, there were no grade 3 and 4 toxicities. Olanzapine containing regimen was comparable with aprepitant containing regimen in control of chemotherapy induced nausea and vomiting. Conclusion: Olanzapine when combined with dexamethasone and granisetron is very effective at controlling nausea and vomiting in patients receiving highly emetogenic chemotherapy. Olanzapine can be a safe, effective and cheaper alternative to aprepitant.
Prognostic Consequences of Anastomotic Leakage in Patients after Laparoscopic Rectal Cancer Resection
Authors: Shiwakoti Enesh , Song Jianning , Li Jun , Zhang Zhongtao
Published: April 2023

Introduction: Anastomotic leakage is the horrendous complication after the laparoscopic rectal cancer resection. The main objective of the present study is to assess the relationship between AL, tumor recurrence and overall survival in rectal cancer patients treated with laparoscopic surgery. Methods: One hundred seventy patients who were diagnosed as rectal cancer with stages 1-3 followed by laparoscopic surgery between March 2012 and February 2017 from Beijing Friendship Hospital were evaluated retrospectively. Twelve factors after laparoscopic surgery were evaluated by the univariate analysis and multivariate analysis. The disease-free survival and overall survival curves were performed by the Kaplan- Meier method and were compared with the log-rank test. Results: The incidence rate of AL was 18.82%. The multivariate analysis showed AL [Hazard Ratio (HR); 3.114, 95% Confidence Interval (CI); 1.029-9.428, P; 0.044], advanced TNM stage [HR; 12.714, 95%CI; 2.364-68.377, P; 0.003] and intraoperative blood loss [HR; 0.269, 95%CI; 0.085-0.859, P; 0.027] were associated with poor OS. In addition, AL [Hazard Ratio (HR); 3.134, 95% Confidence Interval (CI); 1.274-7.711, P; 0.013] and advanced TNM stage [HR; 88.378, 95%CI; 2.231-31.465, P; 0.002] were associated with poor DFS. The logrank test p-value for OS and DFS curve by Kaplan-Meier method were 0.382 and 0.108 respectively. Conclusion: Anastomotic leakage was associated with poorer overall survival and increased risk of tumor recurrence. Moreover, there was no difference in three-year/five-year overall survival rate and disease-frees survival rate between the leakage and non-leakage groups in the present analysis.
Quality of Life in Patients with Gastric Cancer, Translation and Pilot Validation of Nepalese Version of EORTC QLQ Module (STO-22)
Authors: Pandit Subhas , Sapkota Simit , Adhikar Abish , Shrestha Rabi , Khadka Subekshya , Paudel Saurav , Upreti Rachana
Published: April 2023

Introduction: To translate the EORTC QLQ STO-22 for assessment of quality of life of gastric cancer patients in Nepalese language and conduct pilot study of this translation for adapting it to use in Nepalese speaking population. Methods: In the process of translation, we followed the forward-backward translation process according to guidelines recommended by EORTC. Draft version was then pilot tested in a sample of 10 gastric cancer patients. Results: All steps of the EORTC translation guideline were followed successfully. Ten gastric cancer patients were included in the pilot study. Structured interview was conducted with each patient to get feedback on each translated question. Final translated version was created after the pilot study and was approved by EORTC. Conclusion: The Nepalese version of EORTC QLQ STO-22 is a result of a successfully conducted translation procedure. It shows good reliability and is acceptable to Nepalese patients. Further uses in clinical trials and practice will allow for confirmation of its psychometric property.
RANCANG BANGUN PERPUSTAKAAN DIGITAL MENGGUNAKAN FRAMEWORK CODEIGNITER PADA STMIK PRIMAKARA
Authors: Yasa I Wayan Darma , I Putu Satwika  , Eka Grana Aristyana Dewi
Published: April 2023

Digital Library is a library that utilizes information technology to manage library collections or any library activities. Library digitization is a must for every tertiary institution because this is explained in Article 24 Paragraph (3) of Law Number 43 of 2007. In addition, digital libraries are also needed when tertiary institutions carry out university accreditation. However, at STMIK Primakara, the existing digital library system has not been able to fulfill all data such as visit statistics required at the time of accreditation. To overcome these problems, then built a system that can support it. This study uses the Personal Extreme Programming (PXP) method and uses the CodeIgniter Framework as a system actor and in testing system effectiveness using the McLean and DeLone methods. This research succeeded in building and implementing a digital library system that had been designed. From the results of the system effectiveness test carried out by distributing questionnaires to STMIK Primakara students, it can be said that the system that has been built gets pretty good results on almost every variable to test its effectiveness.
PERANCANGAN SISTEM INFORMASI PENGELOLAAN RENCANA ANGGARAN BIAYA (RAB) PADA PERUSAHAAN KONSTRUKSI BERBASIS WEB (STUDI KASUS CV. OSA KARYA MANDIRI)
Authors: Ayu Suarpur Ni Komang Ayu Suarpurningsih , A.A Istri Ita Paramitha
Published: April 2023

At present there are many construction companies spread across Indonesia, so they have competition both in terms of promoting their companies and in terms of bidding on the right and quality construction costs. CV. OSA Karya Mandiri is a construction company that was founded in 2015. The bid for construction costs is CV. OSA Karya Mandiri is currently still recorded manually and computerized using Microsoft Excel version 2010 software which causes many errors to be found in recording and calculating the RAB itself. In order to overcome this, it is necessary to create a system that makes it easier to calculate the budget plan for a construction project by the company. This study aims to design a web-based budget plan management system using the System Development Life Cycle (SDLC) method. The result of this study is an information system for managing budget plans (rab) in web-based construction companies (case study cv. osa Karya Mandiri).
ANALISIS KEPUASAN WISATAWAN TERHADAP LAYANAN TRANSPORTASI ONLINE UNTUK MOBILITAS PARIWISATA DENGAN METODE FUZZY SURVQUAL (STUDI KASUS PROVINSI BALI)
Authors: I Kadek Suyadnya  , I Putu Satwika  , Bagus Wahyu Putu Nirmala
Published: April 2023

Development of technology and information in the modern era that is now sophisticated, the dissemination and receipt of information is now very easy for everyone to do. Technological advances have also led to trends in the use of information technology in various aspects and the media globally. One aspect of the use of this technology can be used in the field of tourism which is commonly referred to as smart tourism where in general smart tourism aims to develop infrastructure and information and communication capabilities in order to improve management/governance, facilitate service/product innovation, and improve the tourist experience.Bali Province is one of the most prominent provinces in Indonesia in the field of tourism where many tourists vacation in Bali. However, in the field of transportation, Bali does not yet have mass transportation that is connected throughout Bali. Because the problems that are not only in Bali, there is the use of technology with the existence of startups in the field of online transportation. This online transportation provider provides various services such as delivery, purchasing food, paying for tickets and others. The existence of online transportation is an alternative for tourists for their mobility, to evaluate the satisfaction of using this transportation, the Fuzzy Servqual method is used. Fuzzy Servqual measures per dimension attribute of service quality so that the accuracy of the data per dimension can be known.
ANALISIS PENGALAMAN PENGGUNA DALAM MENGGUNAKAN LEARNING MANAGEMENT SYSTEM DI STMIK PRIMAKARA
Authors: Jemris Obet Beay  , A.A. Istri Ita Paramitha  , Eka Grana Aristyana Dewi
Published: April 2023

STMIK Primakara Online Learning System (SPADA) is an LMS Learning Management System to carry out an online learning system between lecturers and students by providing classes for each subject in the system so that there is also a discussion of the system so that there is also a discussion of the assignments and there is also campus information related to lectures. exist in the system. This study aims to analyze the STMIK Primakara Online Learning System (SPADA) and find out the experiences of SPADA users. There are usability methods and User Experience Questionnaire (UEQ). Respondents consist of all active students and lecturers who use this system. From the results of the study to get the problem formulation in the introduction where there is still confusion in using SPADA so it is necessary to analyze the system so that it can evaluate improvements.
Antifungal Activity of Efinaconazole Compared with Fluconazole, Itraconazole, and Terbinafine Against Terbinafine- and Itraconazole-Resistant/Susceptible Clinical Isolates of Dermatophytes, Candida, and Molds
Authors: Gamal Ahmed , Elshaer Mohammed , Long Lisa , McCormick Thomas S. , Elewski Boni , Ghannoum Mahmoud A.
Published: April 2023

Background: Recently, an increasing number of resistant-to-terbinafine dermatophytosis cases have been reported. Thus, identifying an alternative antifungal agent that possesses broad-spectrum activity, including against resistant strains, is needed.

Methods: We compared the antifungal activity of efinaconazole with that of fluconazole, itraconazole, and terbinafine against clinical isolates of dermatophytes, Candida, and molds using in vitro assays. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of each antifungal agent were quantified and compared. Susceptible and resistant clinical isolates of Trichophyton mentagrophytes (n = 16), Trichophyton rubrum (n = 43), Trichophyton tonsurans (n = 18), Trichophyton violaceum (n = 4), Candida albicans (n = 55), Candida auris (n = 30), Fusarium spp, Scedosporium spp, and Scopulariopsis spp (n = 15 for each) were tested.

Results: Efinaconazole was the most active antifungal agent tested against dermatophytes, with MIC50 and MIC90 (concentrations that inhibited 50% and 90% of strains tested, respectively) values of 0.002 and 0.03 µg/mL, respectively. Fluconazole, itraconazole, and terbinafine showed MIC50 and MIC90 values of 1 and 8 µg/mL, 0.03 and 0.25 µg/mL, and 0.03 and 16 µg/mL, respectively. Against Candida isolates, efinaconazole MIC50 and MIC90 values were 0.016 and 0.25 µg/mL, respectively, whereas fluconazole, itraconazole, and terbinafine had MIC50 and MIC90 values of 1 and 16 µg/mL, 0.25 and 0.5 µg/mL, and 2 and 8 µg/mL, respectively. Against various mold species, efinaconazole MIC values ranged from 0.016 to 2 µg/mL versus 0.5 to greater than 64 µg/mL for the comparators.

Conclusions: Efinaconazole showed superior potent activity against a broad panel of susceptible and resistant dermatophyte, Candida, and mold isolates.
Change in depression during the COVID-19 pandemic among healthcare providers in Addis Ababa, Ethiopia
Authors: Workneh Firehiwot , Worku Alemayehu , Assefa Nega , Berhane Yemane
Published: April 2023

Background

The COVID-19 pandemic has increased mental health problems among healthcare workers globally. However, studies from low- and middle-income countries on this matter were minimal. This study assessed the change in depression prevalence during the first year of the COVID-19 pandemic and associated factors among healthcare providers in Addis Ababa, Ethiopia.

Methods

We conducted surveys among healthcare workers in Addis Ababa at two-time points, September 2020 and October 2021. A total of 577 study participants were randomly selected based on registers obtained from professional associations. Computer-assisted telephone interviewing technique was used for data collection. The Patient Health Questionnaire (PHQ-9) was used to screen for depression. Multivariable logistic regression analysis was performed to identify potential factors associated with depression.

Result

The prevalence of depression among healthcare workers was 2.3% (95% CI [1.1–4.8]) in Time 1 and 6.5% (95% CI [4.1–10.1]) in Time 2; nearly a three-fold increase in Time 2 compared to Time 1. The most frequently reported symptoms at both times based on the PHQ-9 item were having poor energy, sleep problem, and anhedonia, while reported suicidal ideation was less than 5%. Depression showed a positive and significant association with a positive COVID-19 test result (AOR 7.25 95% CI [1.32–39.4]) in Time 1, and with being a female healthcare provider (AOR 3.96 95% CI [1.08–14.51]) and lack of COVID-19 related policy or guidelines at the workplace (AOR 3.22 95% CI [1.11–9.35]) in Time 2.

Conclusion

The prevalence of depression among healthcare workers tripled during the first year of the COVID-19 pandemic. Panic reaction to positive COVID-19 test result seems to have a negative effect at the beginning while lack of disease-specific prevention guidelines and comprehensive psychological interventions for healthcare providers had an adverse effect on the mental health of health workers.