bluuebunny/crossref_metadata_2025 huggingface dataset:
DIREKTNE STRANE INVESTICIJE U REPUBLICI SRBIJI
Authors: Panić Milorad
Published: January 2025

Rad se bavi analizom direktni stranih investicija na teritoriji Republike Srbije. Period posmatranja analiziranih faktora je od 2017. do 2023. godine, takođe određeni faktori posmatrani su i u tekućoj 2024. godini. Posmatrani makroekonomski faktori su: učešće direktnih stranih investicija u BDP, zaposlensot, indeks zarade i inflacija.
POVIŠENJE ZADOVOLJSTVA KORISNIKA REALIZACIJOM „POSLEDNJE MILJE“ U ISPORUCI DOSTAVE HRANE KURIRSKOM SLUŽBOM
Authors: Radanović Jovana
Published: January 2025

Ovaj rad obuhvata primenu metoda i tehnika rađenih na primeru poslovanja kompanije Glovo i njene platforme za dostavu hrane, U radu je prikazan postupak kreiranja alata, obuhvaćenih u okviru SWOT analize, Ishikawa dijagrama i TOWS matrice, na osnovu čega je data podloga za projektovanje mera unapređenja. Predložene mere unapređenja zasnovani su na planovima održivog razvoja i ispunjenju ekoloških zahteva.
UTICAJ STRESA NA RADNOM MESTU NA ZADOVOLjSTVO POSLOM
Authors: Darmanović Jovana
Published: January 2025

Zadovoljstvo poslom predstavlja opšti stav zaposlenog prema svom radnom angažmanu. Zadovoljni zaposleni imaju pozitivan stav prema svom poslu, dok nezadovoljni gaje negativan stav. Stres na radnom mestu se odnosi na emocionalni i fiziološki odgovor na izazove i zahteve koji proizlaze iz radnog okruženja. Ovaj stres može biti uzrokovan različitim faktorima, uključujući prekomeran rad, nerealna očekivanja, konflikte sa kolegama ili nadređenima, nedostatak kontrole nad radnim zadacima i loši uslovi rada. U cilju ispitivanja kako i u kojoj meri stres na radnom mestu utiče na zadovoljstvo poslom, sprovedeno je istraživanje koje se sastojalo od dve ankete od ukupno 100 ispitanika. Rezultati istraživanja su potvrdili istraživačke hipoteze.
PRIMENA METODA KVALITETA U UNAPREĐENJU LOGISTIČKIH OPERACIJA U AUTO INDUSTRIJI
Authors: Medić Ljubica
Published: January 2025

Logistika i kvalitet su neraskidivo povezani elementi u modernom poslovanju, posebno u složenim industrijama poput automobilske. Kvalitet obuhvata celokupno iskustvo korisnika, doslednost u isporuci i sposobnost kompanije da se prilagodi promenama i konstantno unapređuje svoje procese. U ovom radu opisana su unapređenja u logističkim procesima korišćenjem metoda kvaliteta koje se primenjuju u automobilskoj industriji.
SISTEMATSKI PREGLED TEHNIKA I ALATA ZA OPTIMIZACIJU KORIŠĆENJA SWIFT PROGRAMSKOG JEZIKA
Authors: Melović Sandra
Published: January 2025

Ovaj rad pruža sistematski pregled literature o tehnikama i alatima koje programeri koriste za prevazilaženje izazova sa kojima se suočavaju pri korišćenju Swift programskog jezika. Rad istražuje različite kategorije problema koji utiču na performantnost aplikacija pisanih u Swift-u. Ističe prednosti i ograničenja trenutnih pristupa što omogućava programerima da efikasnije koriste Swift i poboljšaju performanse svojih aplikacija. Takođe, sugeriše pravce za buduća istraživanja koja bi mogla doprineti daljem unapređenju praksi i alata za rad sa pomenutim jezikom.
ALGORITMI ZA REKONSTRUKCIJU SLIKE NA OSNOVU BAJEROVOG MOZAIKA
Authors: Tešanović Tamara
Published: January 2025

U radu je razmatran proces generisanja slike u boji korišćenjem matričnih senzora slike sa Bajerovim mozaikom. Proces obrade slike započinje sa merenjem količine svetlosti u crvenom, zelenom i plavom delu spektra. Umesto razdelnika snopa svetlosti kojim bi se slika projektovala na tri različita fotoosetljiva elementa, u slučaju Bajerovog mozaika koristi se niz kolor filtara sa specifičnim prostornim rasporedom na matričnom senzoru. Način interpolacije nedostajućih spektralnih merenja (uklanjanja mozaika) i redosled operacija kao što su uklanjanje šuma i povećanje prostorne rezolucije nisu proizvoljni i u značajnoj meri utiču na kvalitet rekonstruisane slike. U radu su analizirane tehnike interpolacije zasnovane na Hamiltonovim interpolacionim formulama i vođenom filtriranju slike korišćenjem interpolacije reziduala. Eksperimentalnim poređenjem rezultata rekonstrukcije sa tehnikama koje koriste konvolucione neuronske mreže (CNN) identifikovani su najefikasniji pristupi za poboljšanje kvaliteta slike i uklanjanje mozaika.
PROJEKAT REVITALIZACIJE NAPUŠTENOG OBJEKTA I UNUTRAŠNJEG DVORIŠTA BIOSKOPA EVROPA U KRUŠEVCU
Authors: Kopanja Nevena
Published: January 2025

U okviru svog master projekta, fokusiraću se na izradu predloga idejnog rešenja za revitalizaciju i adaptivnu prenamenu napuštenog prostora unutrašnjeg dvorišta i pomoćnog objekta bioskopa u sklopu hotela Evropa u urbanom jezgru Kruševca, mom rodnom mestu. Kroz adaptaciju jednog dela objekta za potrebe kreativnog haba i kroz izgradnju nove strukture u unutrašnjem dvorištu kako bi se stvorio prostor za odmor, igru, okupljanje, kao i za scenske događaje na otvorenom, želja je oživeti prostor i ukazati na jedan od mogućih načina da postane vitalan deo gradskog života. Ovaj projekat teži stvaranju prostora koji će istovremeno odgovoriti na savremene potrebe, kao i predstavljati integralni deo kulturnog nasleđa, čuvajući duh grada i inspirišući lokalnu zajednicu.
#030 Reabilitação de dentes endodonciados em casos de destruição coronária severa:caso clínico
Authors:   Egas Moniz School of Health & Science, Egas Moniz School of Health % 26 Science, Tenda Diogo , Carvalho Rui ,   Egas Moniz School of Health & Science, Egas Moniz School of Health % 26 Science
Published: January 2025

Introdução: Com os avanços na dentisteria restauradora e conservadora, a reabilitação de dentes com perda severa de estrutura, utilizando abordagens mais conservadoras e procurando preservar o máximo de estrutura dentária remanescente, tornou-se cada vez mais comum. Contudo, dentes com extensa destruição coronária, tratados endodonticamente e com pouca estrutura cervical remanescente, continuam a representar um desafio. Descrição do Caso Clínico: Paciente do sexo feminino, 43 anos de idade, dirigiu- se à Clínica Universitária Egas Moniz, com objectivo de reabilitar o dente 44, de uma forma económica e conservadora. O exame clínico revelou extensa lesão de cárie com envolvimento pulpar e destruição de estrutura coronária. Após a realização do tratamento endodôntico foi colocado um espigão em fibra de vidro com confeção de um núcleo em resina, preparação vertical e confecionada uma coroa provisória. Após 15 dias, e com os tecidos devidamente cicatrizados, foi realizada a impressão. Realizada e aprovada a prova em PMMA, procedeu-se à cimentação da coroa cerâmica final em dissilicato de lítio com um cimento autoadesivo resinoso. Discussão e Conclusões: A escolha da abordagem terapêutica para reabilitar um dente desvitalizado depende de vários fatores. Os pré-molares estão sujeitas a forças mais complexas. Por isso, podem precisar da colocação de um espigão em casos de destruição coronária severa. Neste contexto, os espigões de fibra de vidro, pelas propriedades físicas semelhantes às da dentina natural, são atualmente a opção preferida. Além disso, as restaurações indiretas são uma boa alternativa às restaurações diretas em cavidades de três, ou mais, paredes. Do ponto de vista biomimético, preservar e conservar a estrutura do dente é essencial. Nesse sentido, as preparações com linha de acabamento vertical são menos invasivas em comparação com as preparações horizontais. Este caso clínico demonstra a aplicação bem-sucedida de técnicas modernas e materiais avançados na reabilitação de dentes com destruição coronária extensa, resultando numa reabilitação estética e funcional.
#032 Planeamento digital estético no setor anterior: Caso clínico
Authors:   Egas Moniz School of Health & Science, Egas Moniz School of Health % 26 Science, Rosa Rita , Marquês Martim ,   Egas Moniz School of Health & Science, Egas Moniz School of Health % 26 Science, Carvalho Rui ,   Egas Moniz School of Health & Science, Egas Moniz School of Health % 26 Science
Published: January 2025

Introdução: Com os avanços tecnológicos, o enceramento digital tem-se tornado cada vez mais prevalente, demonstrando ser mais preciso, exato e menos desconfortável para o paciente em comparação com as impressões tradicionais. As coroas e facetas dentárias, fundamentais na medicina dentária moderna, oferecem soluções para problemas funcionais e estéticos, e podem utilizar materiais de alta resistência como a zircónia e o dissilicato de lítio, que mostram aumentar a durabilidade e melhorar os resultados. Descrição do Caso Clínico: Paciente do sexo feminino, de 50 anos, que compareceu na clínica dentária com fratura do dente 11. Realizámos a restauração pré-endodôntica e posterior tratamento endodôntico. Foi feito um scan recorrendo ao scanner intraoral 3Shape, enceramento digital pelo software Meshmixer e subsequente impressão do modelo 3D. Uma chave de silicone foi utilizada para a realização do mock-up e consequentes provisórias em resina bisacrilica AcryTemp. Realizou-se o preparo da coroa no dente 11 com a técnica Vertiprep e o preparo da faceta guiada pelo mock-up no dente 21, devido a ser uma zona estética e de forma a ficar mais harmonioso. Fez-se a dupla impressão (com Light e Putty) para obter os modelos de trabalho. Realizou-se duas provas em PMMA. Por fim, procedeu- se à cimentação da coroa em zircónia com RelyX Unicem 2 Automix (3M) e adesão da faceta em dissilicato de lítio com resina Filtek Z100 (3M) aquecida a 55ºC. Discussão e Conclusões: O uso de scanners intra-orais e softwares de desenho em 3D possibilitam uma captação e manipulação detalhada de imagens, além de melhorarem a comunicação entre médicos dentistas, pacientes e técnicos de prótese dentária, sendo especialmente útil para reabilitações orais com coroas ou facetas dentárias.
GAS CHROMATOGRAPHY METHOD OF CLEANING VALIDATION PROCESS FOR 2-PROPANOL RESIDUE DETERMINATION IN PHARMACEUTICAL MANUFACTURING EQUIPMENT
Authors: Czubak Łukasz , Krygier Alina , Tejchman-Małecka Bożena
Published: January 2025

Cleaning validation is an integral operation of good manufacturing practice in pharmaceutical industry. The aim of this study was to validate simple analytical method for detection of 2-propanol residue in equipment, which is likely contaminated with 2-propanol, usually used in the production area. The gas chromatography with flame ionization detection (GC-FID) method was validated on a GC system using DB-FFAP capillary column at the flow rate of 4.9 mL/min. The calibration curve was linear over concentration range from 2.8µg/mL to 110.7µg/mL with a correlation coefficient equal to 0.99981. The detection limit (LOD) and quantitation limit (LOQ) were 1.1µg/mL and 2.8µg/mL, respectively. The simplicity of gas chromatography method makes it useful for routine analysis of 2-propanol residue and is an alternative to corresponding methods.
SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL 2-[(5-ARYL)-4, 5-DIHYDRO-1H-PYRAZOLE-3-YL]-1H-BENZIMIDAZOLES WITH ANTIMICROBIAL ACTIVITY
Authors: Kunduru Ravinder Reddy , Vanga Malla Reddy , Boche Srinivas
Published: January 2025

A novel series of 4-(1H-benzo[d]imidazol-2-yl)-6-phenyl-2-pyrimidinamines (6a-h) have been synthesized in good to excellent yields by using commercially available o-phenylenediamine (o-PDA) (1a-d) and α-hydroxy propionic acid 2 and by involving 2-(α-hydroxy)ethyl benzimidazoles (3a-d), 2-acetyl benzimidiazoles (4a-d) and 1-(1H-benzimidazol-2-yl)-3-(substituted phenyl) prop-2-en-1-ones (5a-h) as intermediates. The chemical structures of the all newly synthesized compounds were clarified by their IR, 1H & 13C NMR, mass spectral data and elemental analysis. Finally, the target compounds were used to find their antimicrobial activity against various microorganisms.
STANDARDIZATION OF CHITRAKADI VATI: AN AYURVEDIC POLYHERBAL FORMULATION
Authors: Khanvilkar Vineeta , Patil Leena , Kadam Vilasrao
Published: January 2025

Standardization of herbal formulation is essential in order to assess the quality, purity, safety and efficacy of drugs. World health organization (WHO) in 1999 has given a detail protocol for the standardization of herbal drugs comprising of a single content but very little literature is available for the standardization of polyherbal formulations. Chitrakadi Vati is official in ayurvedic formulary of India and it is prescribed for the treatment of irritable bowel syndrome, rheumatoid arthritis and loss of appetite. In the present work, attempt has been made to develop a chromatographic method for standardization of Chitrakadi Vati. All raw materials used were standardized by macroscopic, microscopic and physico-chemical parameters. Piperine in Piper nigrum and Piper longum; Plumbagin in Plumbago zeylanica are active components in the formulation and can be considered as marker compounds. A simple, rapid, precise, accurate and reproducible High Performance Thin Layer Chromatography (HPTLC) densitometric method was developed. The separation was performed on TLC aluminium plates precoated with silica gel 60 F254, good separation was achieved in the mobile phase of toluene: ethyl acetate: formic acid (7.5:2.5:0.5 v/v/v) and densitometry determination of piperine (0.39 ± 0.02) and plumbagin (0.70 ± 0.02) was carried out at single wavelength scanning at 280 nm. The developed method has been validated as per ICH (International conference on harmonization) guidelines. The developed and validated HPTLC method was applied for standardization of Chitrakadi Vati by detection and quantification of markers piperine and plumbagin simultaneously from in-house and marketed formulations.
INVOLVEMENT OF NITRIC OXIDE IN THE ADAPTOGENIC EFFECT OF BACOPA MONNIERA (BRAHMI)
Authors: KU Bansod , SN Umathe
Published: January 2025

Bacopa monniera (BM) is an Ayurvedic medicine, used for centuries as nootropoic, anxiolytic, antidepressant, analgesic, antipyretic, antiepileptic agent and adaptogen. Adaptogens are drugs that promote non-specific resistance of the body and recognized as useful anti-stress agents. Although, the adaptogenic effect of BM is well documented, its mechanism is still not well defined. Stress is known to increase nitric oxide (NO) level in brain tissues, moreover, BM reported to inhibit iNOS expression in vitro. Hence, the present investigation was designed to evaluate the involvement of NO in adaptogenic effect of BM. Mice were exposed to overnight audiogenic stress from day 1 to 10. Various drugs treatments were given before the exposure on each day. Effects of stress were assessed interms of anxiety by social interaction and depression by forced swim test. Results showed that exposure to audiogenic stress significantly induced anxiety and depression on day 1 and 4, whereas, no difference after day 7 and 10, indicated adaptation to stress. Administration of BM (40 and 80 mg/kg, p.o.) attenuated the effect of audiogenic stress and facilitated the adaptation to stress. L-arginine impaired the adaptation to stress. In addition, concomitant administration of BM and L-NAME or 7-NI produced synergistic effect in audiogenic stress mice. Moreover, BM attenuated the effects of L-arginine. Further, BM administration significantly decreased audiogenic stress-induced increased NOx levels in cortex, hypothalamus and hippocampus. Thus, BM has significant adaptogenic activity and this effect is probably medicated through nitrergic system.
PREPARATION, BIODEGRADATION OF COCONUT OIL DRIVEN CHEMICALLY MODIFIED BOVINE SERUM ALBUMIN MICROPARTICLES OF ENCAPSULATED CICER ARIETINUM AMYLASE AND STUDY OF THEIR APPLICATION IN WASHING DETERGENTS
Authors: Rani Kirti , Mehta Vartika
Published: January 2025

In present work, Cicer arietinum amylase was encapsulated by emulsification through covalent coupling by glutaraldehyde into chemically modified bovine serum albumin. Biodegradation of coconut oil driven emulsified bovine serum albumin encapsulated Cicer arietinum amylase was carried out by the alkaline protease for its controlled and sustained release of encapsulated enzyme from prepared microparticles of encapsulated Cicer arietinum amylase and its stability increased up to 6 months as compared to free enzyme. Its biodegradation was carried out by the using different concentration of alkaline protease (5U, 10U, 15U, 20U, 25U, 30U, 35U, 40U). Further, this coconut oil driven chemically modified bovine serum albumin microparticles of encapsulated Cicer arietinum amylase with alkaline protease were used with detergents for washing of stained cloths which have rust, gel pen ink, grease and chocolate strains. These chosen strains are very commonly present on uniforms of school going children which are very tough upon drying, hence, not to be easily vanish with well known brand detergents upon in one wash. But, the mixture solution of coconut oil driven chemically modified bovine serum albumin microparticles of encapsulated Cicer arietinum amylase along with alkaline protease were used with detergents powder for washing of these dry tough strains (rust, gel pen ink, grease and chocolate strains) leads to vanishing these strains very fast with absolute clear results were found as compared to results of washing of stained cloths with detergents only.
ANALGESIC AND ANTI-INFLAMMATORY EVALUATION OF ETHANOLIC EXTRACT OF SEENTHIL CHURANAM
Authors: Rajalakshimi V. , Gauthaman K. , Alhazzani Adel Ali , Kamalraj R. , Nisar Nazima , Devdass G.
Published: January 2025

The polyherbal formulation of Seenthil churanam is composition of whole plant extracts of Eclipta prostata, Tinospora cordifolia and the dried powder form of Earthworm used in folk medicine. The study was conducted to evaluate the scientific figures for the treatment of anti-inflammatory and analgesic activity of ethanolic extract of Seenthil churanam by acetic acid induced writhing test and eddy’s hot plate method, and carrageenan induced paw edema method. There was significant response in analgesic and inflammatory activity at high dose (400 mg/kg) compared to low dose 200 mg/kg against the standards Analgin (500 mg/kg), Aspirin (100 mg/kg) and Diclofenac sodium (100 mg/kg) body weight of mice and rats. The results of this study show that the chronic oral administration of an ethanolic extract of Seenthil churanam at a 400 mg/kg body weight dosage be a good alternative natural medicine for analgesics and anti-inflammatory drug without side effects.
EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT MOMORDICA CHARANTIA UNRIPEN FRUIT
Authors: Saldanha T. , Kaspate D. , Karmarkar B. , Shah K. , Narkhede S.
Published: January 2025

The aim of the present study was to investigate the antidepressant activity of Momordica charantia in swiss albino mice. In this study ethanolic extract of unripen fruit along with seeds of this plant was investigated by using animal models like Despair Swim Test (DST) and Tail Suspension Test (TST) along with 100, 300 and 500 mg/kg (p.o.) doses and distilled water as a vehicle for 14 days of treatment and imipramine as a standard drug was administered orally on the test days. During dosing period test was carried out on 1st, 7th and 14th day of treatment. The results showed a significant decrease in immobility time of treated mice as compared to control group.
IDENTIFICATION OF CYTOTOXIC AND ANTIOXIDANT COMPOUNDS FROM ALLIUM GRAMINEUM FLOWERS
Authors: Mskhiladze Lasha , Chincharadze David , Tits Monique , Wauters Jean- Noël , Bellahcène Akeila , Castronovo Vincent , Mickalad Ange Mouithys- , Franck Thierry , Frédérich Michel
Published: January 2025

The present study evaluates the in vitro anticancer, antiplasmodial and antioxidant activity of the ethanolic crude extract from the flowers of Allium gramineum growing in Georgia and of one flavonol and two steroidal glycosides which were isolated from this plant. The flowers were extracted with ethanol and this total extract was subjected to successive bioguided fractionations to provide glycosides 1-3. Their structures were elucidated on the basis of NMR and ESI-MS spectrometric data in comparison with the existing literature and have been identified as: isorhamnetin-3-O-β-D-glucopyranoside (1), diosgenin-3-O-α-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (Prosapogenin A of dioscin) (2), diosgenin-3-O-α-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-]-β-D-glucopyranoside (Deltonine) (3). The ethanolic extract has been shown to strongly inhibit the growth of breast adenocarcinoma cell lines, with an IC50 of 4.5 ± 0.7μg/mL for MDAMB-231 and 4.8 ± 0.9μg/mL for MCF-7 cells. The cytotoxic activity was related to 2 and 3 which exhibited potent cytotoxicity, with an IC50 of ± 3μM. Concerning antiplasmodial activities, only weak activities were observed using the ethanolic extract and the two saponins. The flavonoid was almost inactive. Finally, the radical-scavenging activity of the ethanolic extract was tested in presence of ABTS•+ solution. A decrease of the absorbance intensity was observed, with an IC50 value of 22.1 ± 0.6μg/mLwhile trolox, used as Standard drug, showed a pronounced activity (IC50 = 12.7±0.5μM). The glycoside 1 showed the lowest IC50 value of 20.1 ± 0.8μM while both 2 and 3 exhibited very weak radical scavenging activity.
SIMULTANEOUS ESTIMATION OF GUGGULSTERONE E, GUGGULSTERONE Z, KBA, AKBA, WITHAFERIN A AND 6-GINGEROL BY USING HPLC-DAD METHOD FROM ARIFLEX TABLET FORMULATION
Authors: Patil Pankaj , Nipanikar Sanjay , Bhusnar Hanumant , Nagore Dheeraj
Published: January 2025

Simple, accurate, precise, sensitive and validated HPLC method was developed for simultaneous determination of Guggulsterone E (GE), Guggulsterone Z (GZ), 11-keto-β-boswellic acid (KBA), 3- Acetyl 11-keto-β-boswellic acid (AKBA), Withaferin A (WA) and 6-Gingerol (GNRL) in Ariflex tablet. The gradient RP-HPLC analysis was performed on Inertsil ODS-3V C18 column (250 × 4.6 mm id), using a mobile phase consisting of 0.1% Ortho-phosphoric acid and mixture of acetonitrile: Methanol (50: 50 v/v) in solvent gradient elution for 60 min at a flow rate of 1.0 mL min−1. Quantification was carried out using a photodiode array detector at 225nm. The employment of diode array detector allowed selectivity confirmation by peak purity evaluation. The method was validated according to International Conference on Harmonization guidelines. No chromatographic interference from tablet excipients was found and hence this method is applicable for simultaneous determination of GE, GZ, KBA, AKBA, WA and GNRL in Ariflex Tablet.
A NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF TRIFLUOPERAZINE AND ISOPROPAMIDE IN TABLET DOSAGE FORM
Authors: Pattanayak Suman , Y. Ash Rani
Published: January 2025

The present paper describes a reverse phase HPLC method for simultaneous estimation of Trifluoperazine and Isopropamide from their combined tablet dosage form. The proposed RP-HPLC method utilizes an Agilent Zorbax, C18 column (250 × 4.6 mm, 5μm particle size) using a mobile phase consisting of mixture of Buffer: Acetonitrile (80: 20 v/v) mobile phase flow rate of 0.8 ml/min; and UV detection at 227nm. The retention time for Trifluoperazine and Isopropamide were 2.4 and 3.62 minutes respectively. The method was linear in the range of 40-120μg/ml and 100-300μg/ml and correlation coefficients were 1.00 and 1.00 for Trifluoperazine and Isopropamide respectively. The limit of detection was found to be 2.963 and 2.985µg/ml for Trifluoperazine and Isopropamide respectively. Limit of quantification was found to be 9.877 and 9.9502 for Trifluoperazine and Isopropamide respectively. The percentage recoveries for Trifluoperazine and Isopropamide ranged from 100.03-100.36% and 100.00-100.07 % respectively. The percentage of RSD for precision of the method was found to be less than 2%. The proposed method can be used for the routine analysis for the estimation of these drugs in combined dosage form.
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF NEBIVOLOL HYDROCHLORIDE AND AMLODIPINE BESYLATE IN TABLET DOSAGE FORMS BY RP-HPLC
Authors: N Usha Rani , B Satya Priya , Ankani Nagoor
Published: January 2025

A simple, specific and precise high performance liquid chromatographic method was developed and validated for Nebivolol HCl and Amlodipine besylate in a combined tablet dosage form. Nebivolol hydrochloride, a long acting, cardioselective β-blocker and Amlodipine besylate, a calcium channel blocker are considered in combination for the treatment of hypertension. The chromatographic separation was performed using Eclipse XDB plus C18 Column (4.6 × 150 mm, 5μm particle size). The mobile phase consisted of combination of 0.01 M Ammonium acetate buffer (pH 4.5) and Acetonitrile in the ratio of 50:50 v/v at a flow rate of 0.8 ml/min with the detection wavelength at 265 nm. Both the drugs showed good linearity in the concentration range of 10-50μg/ml and 5-25μg/ml respectively with a correlation coefficient of 0.999 for both drugs. The retention time for Nebivolol HCl and Amlodipine besylate were found to be 3.553 and 2.970 min respectively. The developed analytical method was validated for linearity, precision, accuracy, ruggedness, robustness, specificity and system suitability, which were within the acceptance limits according to ICH guidelines. The developed method can successfully be employed for routine quality control of Nebivolol HCl and Amlodipine besylate in combined tablet dosage forms.
DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) METHOD FOR DETERMINATION OF FIPRONIL AND PYRIPROXYFEN IN A VETERINARY PHARMACEUTICAL PRODUCT
Authors: Neagu M. , Soceanu G. , Bucur A. , Tanase A.
Published: January 2025

In the present study, an analytical HPLC method was developed for the estimation of Fipronil, Pyriproxyfen, Benzyl alcohol, Butylhydroxyanisole (BHA) and Butylhydroxytoluene (BHT) and related substances from a veterinary pharmaceutical product. The method showed linearity in the range of 0.44-200% with a correlation coefficient of 0.99. The method was validated for different validation parameters such as: specificity (peak identification and interference study), precision, accuracy, linearity, robustness, limit of detection (LOD) and limit of quantitation (LOQ), stability of standard solutions and sample solution. The results were found to be within the acceptance limits as per ICH guidelines.
DEVELOPMENT OF COMPRESSION COATED PANTOPRAZOLE TABLETS USING SPRAY DRIED POLYMER BLEND: EVALUATION AND PROCESS OPTIMISATION BY EXTREME VERTICES DESIGN
Authors: Rath Seemanchala , Pal Arna , Surai Somnath , Das Debanjan , Maiti Richinandan , Bala Nripendra Nath , Ray Krishnanghu , Gupta Bijan Kumar
Published: January 2025

In the present investigation, a combination of Eudragit L 30 D 55 and ethyl cellulose are used as enteric materials in a spray dried form to constitute the barrier layer for compression coating of directly compressed PSS core tablets. The study also includes analysis of the effect of Eudragit L 30 D 55 and ethyl cellulose and their optimisation using an extreme vertices design. Dissolution profile of compression coated tablets was best fitted to zero order and first order dissolution models. Mechanism of drug release was found to be Super case - II transport in all the batches as evidenced from the release exponent values of the Korsmeyer Peppas model. Mixture regression equations have indicated that Eudragit L 30 D 55 has more contribution towards the delayed drug release pattern, because it controls drug release below pH 6 in the acidic medium. Normal probability plots supported the accuracy of the chosen mixture design model for studying the effect of independent mixture variables, and had also shown that the residual values of response variables were minimal. Press coated tablets prepared using these optimised ratios of two mixture components have shown no statistical significant difference between their predicted and observed values of response variables as evidenced from the paired t-test (p-value > 0.2 in all the cases).
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF OLANZAPINE BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: Murthy Ayyagari Rama , Babu K. Raghu , Vekariya N. A.
Published: January 2025

Objective of the study was to develop and validate a new rapid, sensitive, reverse phase High Performance Liquid Chromatography technique for the estimation of Olanzapine in bulk and dosage form. Chromatographic separation was achieved on a BDS Hypersil C18, (150 mm × 4.6 mm, 5μm) with a mobile phase of 0.01M Tetra butyl ammonium hydrogen sulphate: Methanol (60:40) v/v. The flow rate was 1.0 ml/min, temperature of the column was maintained at ambient and detection was made at 228 nm. The run time was as short as 10.0 min. The developed method was validated according to the International Conference on Harmonization (ICH) guidelines with respect to linearity, accuracy, precision, specificity and robustness. The developed method was linear for Olanzapine from 10 - 80μg/ml and the linear regression obtained was 0.9994. Recovery of Olanzapine was found to be in the range of 99.6 -101.7%. Precision, evaluated by intra- and inter-day assays had relative standard deviation (R.S.D) values within 1.0 %. The ruggedness of the method was validated by performing the analysis by two different analysts and no significant difference in the result was found. Robustness of the method was checked by varying flow rate by 0.2 ml/min and the result was not affected significantly. The analysis of the marketed sample indicated that the method can also be applied to dosage form successfully. The method is precise, accurate, linear, robust and fast. The retention time and run time was very short; hence it is cost effective, making it more economical and rapid. Hence, this method can be used for the analysis of large number of samples.
A REVIEW ON THERAPEUTIC POTENTIAL OF POLYHERBAL FORMULATIONS
Authors: Barik C. S. , Kanungo S. K. , Tripathy N. K. , Panda J. R. , Padhi M.
Published: January 2025

Nature has been a source of medicinal agents for more than thousands of years and herbal therapy predominates in traditional systems of medicine as well as in alternative medicine practiced in various cultures such as Indian system of medicine, Chinese Traditional Medicine, Unani classical literature. The present review deals with various polyherbal formulations used by different countries of the world. Information on traditional herbal formulations was documented in the form of research and review articles in various journals. The aim of this review is to summarize the different types of herbs used for the preparation of polyherbal formulations, their therapeutic potentials including clinical and preclinical results along with their safety and efficacy. This review will facilitate to gain all about the past scientific research and the necessary information about the enormous pharmacological activities of polyherbal formulations which will insist the young researchers for future research to protect human beings from various types of diseases and may serves as a natural gold for the promotion of mankind.
QUALITY CONTROL OF A MARINE ORIGIN BASED HERBO-MINERAL UNANI FORMULATION
Authors: Aslam Mohd , Tariq Mohd , Farhan Katheem M. , Ahmad Mohd Aftab , Jolly Reshma , Siddiqui Aisha
Published: January 2025

Kushta Marjan (KM) is one well-known formulation prepared from coral used by Unani physicians for effective treatment of a various ailments. Coral is the calcareous skeleton of the minute marine organism and belongs of phylum coelenterate and is used internally in the form of kushta. It is highly efficacious in Cough, Asthma and Anorexia. Till date no scientific work has been performed to establish quality control of KM. In this study we have enlightened the preparation procedures, structural, functional and physico-chemical properties of KM by analyzing it on classical tests along with modern scientific techniques like FTIR (Fourier-transform infrared spectroscopy), TGA (Thermogravimetric Analysis) and DSC (Differential Scanning Calorimetry) to establish its quality control parameters. FTIR spectra showed peaks attributed to calcium oxide, organic matter and several other substances. Total weight loss during TGA was 30.09% and DSC curve showed peaks at 20°C, 65°C, 183°C and 261°C. Since the study has been first of its kind the results obtained might be taken as standard finger print of kushta marjan and might be helpful for further formulation and standardization of KM in routine analysis.
DEVELOPMENT AND VALIDATION OF ISOCRATIC STABILITY INDICATING REVERSE PHASE LC METHOD WITH PDA DETECTION FOR SIMULTANEOUS ESTIMATION OF OLMESARTAN MEDOXOMIL AND HYDROCHLOROTHIAZIDE IN ITS MARKETED FORMULATION
Authors: Yunoos Mohammad , Sankar D. Gowri
Published: January 2025

A simple and precise stability indicating RP-HPLC method was developed and validated for simultaneous determination of Olmesartan Medoxomil (OLM) and Hydrochlorothiazide (HCTZ) in pure drug and Pharmaceutical marketed formulation. Chromatography was carried out on Inertsil ODS C18 (150 × 4.6 mm, 5m particle size) column in an isocratic mode with mobile phase containing 0.2 % acetate buffer and acetonitrile in the ratio of 60:40% v/v at a flow rate of 1.0 ml/min. The analyte was monitored using PDA detector at 252 nm. The retention time was found to be 5.080 min and 10.493 min for Hydrochlorothiazide (HCTZ) and Olmesartan Medoxomil (OLM) respectively. The proposed method was found to be having linearity in the concentration range of 20-120µg/ml for Olmesartan Medoxomil (OLM) and 12.5-75.0µg/ml for Hydrochlorothiazide (HCTZ) with correlation coefficient value of 0.999 respectively. The mean % recoveries obtained were found to be 99.86-100.02 % for Hydrochlorothiazide (HCTZ) and 99.92-100.16 % for Olmesartan Medoxomil (OLM) respectively. Stress testing which covered acid, base, peroxide, UV light, neutral and thermal degradation was performed on under test to prove the specificity of the method and the degradation was achieved. The developed method has been statistically validated according to ICH guide lines. Thus the proposed method can be successfully applied for the stability indicating simultaneous determination of Olmesartan Medoxomil (OLM) and Hydrochlorothiazide (HCTZ) in bulk and combined tablet dosage form and in routine quality control analysis.
Tierra Nueva, familias y generaciones
Authors: Martínez Baracs Rodrigo
Published: January 2025

Tierra Nueva. Revista de Letras Universitarias apareció en la Ciudad de México en los años 1940, 1941 y 1942, con el apoyo de la Universidad Nacional Autónoma de México. La dirigieron tres jóvenes literatos nacidos en 1918 –Alí Chumacero, Jorge González Durán y José Luis Martínez– y un filósofo algo mayor, nacido en 1912 –Leopoldo Zea. La revista se imprimió pulcramente en la Imprenta Universitaria, al cuidado de Francisco Monterde y Julio Prieto. En un comienzo, era una revista estudiantil, con el apoyo de algunos mayores reconocidos, pero pronto adquirió personalidad como revista literaria, con los poemas de Chumacero y la crítica literaria de Martínez. La revista fue importante en la vida de sus responsables, que emprendieron carreras literarias diferentes, y jugó un papel significativo, entre las revistas Letras de México, Taller y El Hijo Pródigo, en un momento particularmente fructífero de las letras mexicanas.
Tierra Nueva, Families and Generations
Abstract
Tierra Nueva. Revista de Letras Universitarias was published in Mexico City in 1940, 1941, and 1942, with the support of the Universidad Nacional Autónoma de México. Its directors were three young writers born in 1918 –Alí Chumacero, Jorge González Durán, and José Luis Martínez– and a philosopher a little older, born in 1912 –Leopoldo Zea. The review was printed in the Imprenta Universitaria, under the care of Francisco Monterde and Julio Prieto. At the beginning, it was a student’s review, with the support of a few wel-established “grown-ups”, but it soon got its own personality as a literary review, with Chumacero’s poems and Martínez’s literary criticism. The review was important in the life of its directors, that would lead different literary careers, and played a role, between the reviews Letras de México, Taller, and El Hijo Pródigo, in a particularly fruitful moment in Mexican letters.
Recibido: 28 de julio de 2024Dictaminado: 3 de octubre de 2024Aceptado: 19 de noviembre de 2024
Una casa de papel y celuloide: Nuevo Cine (1961-1962) y la reinvención de la crítica cinematográfica mexicana
Authors: Sánchez Prado Ignacio M
Published: January 2025

Este ensayo propone una lectura de la revista Nuevo Cine (1961-1962), enfocada en su intervención en la interpretación histórica del cine mexicano y su constitución de un canon de cine mundial dentro de la encrucijada de inicios de los sesenta. Con particular énfasis en los escritos de Salvador Elizondo, Jomi García Ascot y José de la Colina, el ensayo discute el posicionamiento crítico de la revista frente a temas como la crisis del cine industrial, la cuestión de lo humano y la evaluación de las revoluciones formales de la cinematografía. En el ensayo, se discuten también los posicionamientos de estos críticos frente a varios directores del cine de la época: Fernando de Fuentes, Otto Preminger, Federico Fellini, Nicholas Ray y Jean-Luc Godard, entre otros.
A House of Letters and Celluloid: Nuevo Cine (1961-1962) and the Reinvention of Mexican Film Criticism
Abstract
This essay proposes a reading of the magazine Nuevo cine (1961-1962), focused on its intervention in the historical interpretation of Mexican cinema and its constitution of a canon of world cinema in the context of the crossroads that defined the early sixties. With particular emphasis in the writings of Salvador Elizondo, Jomi García Ascot and José de la Colina, the essay discusses the magazine’s critical positioning in relation to the crisis of industrial cinema, the question of the human and the assessment of the formal revolutions in cinematography. The essay also discusses the positions of these critics in relation to a series of filmmakers from the time: Fernando de Fuentes, Otto Preminger, Federico Fellini, Nicholas Ray, and Jean-Luc Godard, amongst others.
Recibido: 30 de julio de 2024Dictaminado: 4 de noviembre de 2024Aceptado: 27 noviembre de 2024
Los orígenes “neoliberales” de El Malpensante. Lecturas paradójicas (1996): paradojas de la cultura colombiana
Authors: Pineda Buitrago Sebastián
Published: January 2025

El artículo analiza la revista colombiana El Malpensante. Lecturas paradójicas, fundada en 1996, como un caso de estudio para explorar el impacto del neoliberalismo cultural en la prensa latinoamericana. Se investiga cómo la revista ha logrado mantenerse relevante al adaptarse a formatos impresos y digitales, desafiando la hegemonía cultural estatal y nacionalista. Igualmente, se examina si esta publicación adopta una perspectiva cosmopolita influenciada por el periodismo cultural angloamericano. La metodología incluye un estudio de contenido editorial y publicitario, así como una revisión teórica sobre estudios culturales y publicaciones periódicas.
The “neoliberal” Origins of El Malpensante. Lecturas Paradójicas (1996): Paradoxes of Colombian Culture
Abstract
The article examines the Colombian magazine El Malpensante. Lecturas paradójicas, established in 1996, as a case study to explore the impact of cultural neoliberalism on Latin American press. It investigates how the magazine has remained relevant by adapting to both print and digital formats, challenging state and nationalist cultural hegemony. At the same time, it assesses whether this publication adopts a cosmopolitan perspective influenced by Anglo-American cultural journalism. The methodology includes an analysis of editorial and advertising content, alongside a theoretical review of cultural studies and periodical publications.
Recibido: 16 de agosto de 2024Dictaminado: 24 de octubre de 2024Aceptado: 25 de noviembre de 2024
Julio Ramos. (2022). Paradojas de la letra. Lengua, subjetividad y ley.
Authors: García de la Sienra Rodrigo
Published: January 2025

Resulta afortunado que, después de que las dos primeras ediciones de este libro (1996, 2006) se volvieran inaccesibles, Mimesis nos brinde ahora la oportunidad de acceder a esta faceta del trabajo de Julio Ramos, sin duda complementaria de aquella, ampliamente conocida, que quedara consignada en Desencuentros de la modernidad en América Latina. Literatura y política en el siglo XIX.
Emiliano Martín del Campo y otros. (2024). Narradores mexicanos del siglo XXI (Entre la entropía y la neguentropía).
Authors: Gálvez Peralta Víctor
Published: January 2025

La literatura contemporánea se caracteriza por desbordar las categorías de análisis previas; de igual forma, se requiere que las aproximaciones teóricas se transformen. La crítica literaria actual marcha por un derrotero donde resulta difícil ponderar en su justa medida los aportes recientes; sin embargo, con la obra Narradores mexicanos del siglo XXI (Entre la entropía y la neguentropía) se propone un sendero. Tanto a nivel temático, como en el apartado metodológico, la apuesta es arriesgada: el corpus de obras en revisión es heteróclito e incluso, podría decirse, sui generis, de tal suerte que el lector se encuentra ante una cuidadosa selección de artículos críticos entre la entropía y la neguentropía.
Revista Mexicana de Literatura y Cuadernos del Viento: espacios cosmopolitas para la Generación del medio siglo
Authors: Hernández y Rojas Mariana
Published: January 2025

Los autores de la Generación del medio siglo se insertaron en un campo literario restringido. En respuesta, crearon un habitus a través de declaraciones simbólicas cosmopolitas opuestas a las imposiciones nacionalistas del poder. Para ello, recurrieron a prácticas –creación, traducción, crítica– ejercidas en publicaciones como la Revista Mexicana de Literatura y Cuadernos del Viento. En este artículo, siguiendo la metodología de Pierre Bourdieu, se analiza el posicionamiento de estos autores en el campo a partir del cual abrieron espacios a autores dentro y fuera del país, diversificaron los intercambios simbólicos y fijaron un nuevo canon.
Revista Mexicana de Literatura and Cuadernos del Viento: Cosmopolitan Spaces for the Mid-Century Generation
Abstract
The Mid-Century Generation authors formed part of a literary field under strict control of the government. In response, they stablished a habitus through symbolic cosmopolitan declarations challenging the State’s impositions. To achieve this, they turned to practices –publishing, creating, translating, and critique– in publications such as the Revista Mexicana de Literatura and Cuadernos del Viento. Following Pierre Bourdieu’s methodology, we will understand the authors’ positioning within the literary field, where they opened spaces to authors inside and outside the country, diversified symbolic exchanges, and fixated a new cannon.
Recibido: 20 de junio de 2024Dictaminado: 11 de octubre de 2024Aceptado: 22 de noviembre de 2024
Cotch
Authors: Bell-Kovacs Keisha
Published: January 2025

This creative writing piece offers a reflection on a Patwa word and the Third Culture experience.
LA PREGUNTA COMO ESTRATEGIA PARA LA FORMACIÓN DEL PROFESORADO. APORTES DESDE LAS DIDÁCTICAS DE LA MATEMÁTICA, DE LA BIOLOGÍA Y DE LA HISTORIA
Authors: Jara Miguel Ángel , Martínez Rosa , Rassetto María Josefa
Published: January 2025

Las didácticas específicas, como disciplinas del campo educativo, se ocupan de problemas relacionados a la enseñanza y al aprendizaje de un objeto de conocimiento particular. En el caso de los profesorados, las prácticas docentes constituyen uno de los espacios fundamentales desde el cual podemos visibilizar los límites y las posibilidades de la formación. En este trabajo rescatamos el lugar de las preguntas como estrategias formativas y articulamos los aportes, experiencias y saberes de las Didácticas de la Matemática, de la Biología y de la Historia, en el espacio de la práctica. Hacemos foco en las preguntas que se formulan los y las practicantes en sus propuestas de enseñanza; también nos interesa poner en tensión el lugar de la pregunta didáctica como estrategia en la formación, para analizar y reflexionar sobre: ¿cómo abordar las preguntas como problema epistemológico didáctico en la formación del profesorado?
ESCOLARIDAD E INCLUSIÓN: SUBJETIVIDADES TRANS EN EL ÁMBITO ESCOLAR
Authors: Latorre Chávez Rhonny , Salazar Barnechea Arnaldo
Published: January 2025

Este artículo es parte de un esfuerzo por visibilizar la experiencia de escolaridad en personas trans de Chile, en el marco de un modelo educativo estandarizado y binario. Se entrega una contextualización de los estudios y cifras disponibles hasta el momento, y se complementa con relatos concretos de trayectorias educativas de personas género no conforme, haciendo énfasis en los puntos críticos que vuelven la trayectoria educativa -al parecer-, incompatible con la generación de una identidad no binaria.
AMPLIANDO LAS DINÁMICAS DEL PODER: FREIRE Y LA POLÍTICA DE LA RAZA EN LA EDUCACIÓN
Authors: Apple Michael W
Published: January 2025

En este artículo me enfoco en discutir las formas en que las relaciones de poder se ocultan en la educación, la cultura y la economía, enfatizando en la naturaleza del poder diferencial y sobre los efectos de la política de exclusión y de las realidades opresivas que experimentan las personas. Recordando las conversaciones sostenidas con Paulo Freire vuelvo a reflexionar sobre el significado de la identidad y la raza para una pedagogía de los oprimidos y desarrollo lo que le habría dicho a Paulo si nuestras conversaciones hubiesen continuado. Dirigiré mi atención a las realidades de la raza en las naciones con las que estoy más familiarizado, aunque también me referiré a Brasil, Portugal y otros países. Mi base epistemológica será freireana interrogando la "cultura del silencio" en la que vivimos, especialmente los silencios de los grupos dominantes. Sostengo que los grupos dominantes prefieren vivir en una "niebla epistemológica", en la que no ver, no saber, es crucial para su dominio. Concluyo señalando que ver el mundo de manera más política, a través de los ojos de los oprimidos, es una condición necesaria pero no suficiente para la transformación social. Argumentaré que no es posible comprender completamente la génesis y los efectos de las “reformas” neoliberales y neoconservadoras en la educación y la sociedad en un gran número de naciones, sobre las cuales Freire tenía mucho que decir en sus últimos libros, sin colocar a la raza en el centro del análisis crítico
INTRODUCCIÓN Y CONSOLIDACIÓN DE LOS PRINCIPIOS DE MERCADO EN EL DISCURSO OFICIAL SOBRE EDUCACIÓN DE LA DICTADURA CIVIL MILITAR CHILENA (1973-1990)
Authors: Pérez Navarro Camila , Rojas Murphy Andrés
Published: January 2025

Este artículo analiza el cambio discursivo de la dictadura civil militar chilena (1973-1990) respecto a la introducción de principios de mercado en el sistema educativo. A partir de fuentes primarias, se evidencia que se enfrentan dos posiciones diferentes en el diseño de la política educacional, una Estado–docentista o más conservadora, representada por los contraalmirantes que dirigieron el Ministerio de Educación entre 1973 y 1978; y una corriente neoliberal, defendida por el grupo de colaboradores civiles de la dictadura, conocidos como los “Chicago Boys”. Primero, se expone el discurso oficial de la dictadura civil militar sobre educación con posterioridad al Golpe de Estado en septiembre de 1973, el cual estuvo enfocado en la mantención del desarrollo lineal del sistema, el control y depuración de las instituciones y en la planificación del cambio. Posteriormente, se profundiza en la transformación del discurso oficial, el cual transitó desde una estrategia de renovación continua y planificada, basada en la Doctrina de Seguridad Nacional y en una administración educacional desarrollista, a una reforma estructural orientada por el objetivo de una modernización educacional y fundamentada en una racionalidad economicista. Finalmente, se muestra cómo se introdujo mecanismos de mercado en la política educativa y cómo se consolidó la perspectiva neoliberal en el discurso oficial sobre educación.
LA PEDAGOGÍA HISTÓRICO-CRÍTICA, EL CONTEXTO DE SU SURGIMIENTO Y SUS BANDERAS DE LUCHA
Authors: Orso Paulino José
Published: January 2025

En este artículo, partiendo del supuesto de que la Pedagogía Histórico-Crítica se constituye en la principal teoría pedagógica contra hegemónica existente en la actualidad, nos proponemos a rescatar el contexto en que ella surgió, así como, explicitar tanto aquello que ella combate, como lo que defiende.