bluuebunny/crossref_metadata_2025 huggingface dataset:
Tünel Tipi ve Yığma Ağılda Yetiştirilen Kuzuların Büyüme ve Sağlık Özellikleri
Authors: PEHLİVAN Başak , TÖLÜ Cemil , SAVAŞ Türker
Published: June 2021

Amaç: Tüm dünyada olduğu gibi Türkiye’de de koyun yetiştiriciliğinde kuzu ölümleri önemli bir sorundur. Bu sorunun çok farklı nedenleri olmakla birlikte öncelikli nedenin sağlıksız ağıllar olduğu düşünülmektedir. Barınak iklimi, özellikle kötü havalandırma nedeniyle oluşan zararlı gazlar kuzuların büyümesini ve sağlığını olumsuz etkileyebilmektedir. Bu çalışmada, basit, ucuz ve bir tarafı tamamen açık olan bir tünel tipi ağıl (TA) ve yetiştirici koşullarındaki tamamen kapalı yığma ağılda (YA) yer alan Karacabey Merinosu kuzularının büyüme performansı ve sağlık özelikleri incelenmiştir.Materyal ve Metot: Her bir ağıl tipinde anneleriyle birlikte barındırılan 20 baş Karacabey Merinosu kuzular kullanılmıştır. Çalışmada toplam 40 kuzu kullanılmıştır. Kuzular doğum ağırlıkları, cinsiyetleri ve doğum tiplerine göre TA ve YA gruplarına şansa bağlı olarak dağıtılmıştır.Bulgular: Deneme boyunca takip edilen oransal nem, dış çevre için %18 ile %94, TA için %8 ile %97, YA için ise %24 ile %90 arasında değişmiştir. Ağıllardaki NH3 konsantrasyonu ortalaması TA için 6.4 ppm, YA için 15.0 ppm olarak gerçekleşmiştir (P<0.0001). Kuzularda günlük canlı ağırlık artışı 52 günlük yaşa kadar TA için 223.9±21.89 g, YA için 217.9±30.27 g (P=0.8793); aynı değerler 130 günlük yaşa kadar ise TA için 307.5±13 g ve TA için 341±12 g olarak tespit edilmiştir (P=0.0059). Denemenin ilk ayında, hemoglobin (P=0.0186) değerleri ve eritrosit sayıları (P=0.0156) bakımından TA grubunda YA grubundan daha yüksek değerler elde edilmiştir. Ancak denemenin ikinci ayında değerler arası farklılık ortadan kalkmıştır. Yığma ağılda ölüm oranı %30 olurken, tünel tipi ağılda kuzu ölümü gerçekleşmemiştir (P=0.0057).Sonuç: Çalışmada, yığma ağılda kötü havalandırma koşulları nedeniyle ölen kuzular sonrasında, sağlık özellikleri bakımından iki grubun değerlerinin birbirine yaklaştırdığı söylenebilir. Düşük maliyetli olması, kurulumu ve taşınmasının kolay olması nedeniyle, tünel tipi ağılların, özellikle şiddetli rüzgârlara mümkün olduğunca kapalı alanlarda kullanılabileceği ifade edilebilir.
Designing the Holistic Evaluation in Teaching Reading/Tasmim al-Taqwim al-Syumuli Fi Ta’lim al-Muthala’ah
Authors: Rini Rini , Harahap Partomuan
Published: June 2021

The purpose of this article is to design the holistic evaluation in teaching reading. Assessment plays an important role in education process. Good evaluation is essential for good education and good learning. The evaluation of reading material is able to depict the faults and advantages of a reading instruction program. Also, students are able to know the level of their ability and absorption of reading materials from the assessment. The research method used is the library method. Assessment is an important part of teaching reading. So far, there are still found some designs of reading assessment which are not integrated and comprehensive, identical to the theory of reading comprehension including literal reading, interpretive reading, critical reading, and creative reading. As a result of this research, the design of the reading assessment is based upon the teaching and learning process (the daily calendar) or the so-called formative evaluation and an evaluation that is based at the end of the lecture in the form of midterm exams and final exams, or what is called a final evaluation. The evaluation design has two types comprising the practice evaluation and the written evaluation.
Arabic Language and the Concept of I’jaz al-Qur’an (Critics to Louwis ‘Awad’s thoughts/Bahasa Arab dan Konsep I’jaz al-Qur’an (Kritik Pemikiran Louwis ‘Awad)
Authors: Kurniawan Rahadian , Asmara Musda , Hardivizon H
Published: June 2021

This article discusses the concept of I'jaz al-Qur'an and its relationship with Arabic as a form of criticism of the logos concept put forward by Louis Awad. This research is a literature review conducted by collecting related data sources to analyze the character's thought in question. The concept of I'jaz al-Qur'an is a study related to the faith of Muslims, in this case the existence of the al-Qur'an as Kalamullah. Among the Islamic scholars, two views have been very influential since this issue was raised, namely the Asy'ariyah and Mu'tazilah circles. These two groups agree to believe that the Qur'an is Kalamullah. However, in this case, Dr. Louwis expresses this opinion and relates it to the concept of Christian Logos, in which the concept of al-Qur'an, as the eternal Kalamullah (qadim) put forward by two major groups in Islamic Theology, is an adoption of the Christian Logos concept. The misappropriation of the information provided by Dr. Louwis shows his lack of understanding and mastery regarding the issues he addresses in his book. Not supported by historical facts and correct scientific studies, he conveyed in his book a form of hatred against Islam, the Koran and the Arabic language in particular and the Arab nation in general.
Ayat-Ayat Hukum dalam Alquran Mengatur Hubungan Sesama Manusia
Authors: Hendrianto H. , Elfalahy Lutfi
Published: June 2021

This study aims to reveal the legal verses in the Koran, especially the legal verses about human relationships (habluminannas) that have been written in the Koran, as a guide or reference for Muslims. Especially in the case, the number of verses regarding muamalah law is relatively small, especially when compared to the law verses on worship. While the development of life seems to continue to change. while the verse has no changes and additions. This research was conducted with literature study, data collection techniques using documentation techniques with data analysis, namely content analysis. The results show that the verses of muamalah law are classified into 7 (seven) sections, including those related to family law, civil law, criminal law, procedural law, administrative law, economic law, and finance. The verse of law regulates fellow human beings or muamalahs which provide little opportunity for Muslims to implement muamalah activities in accordance with the guidelines contained in the Koran and Hadith, if not explicitly explained it is supported by other legal products such as ushul fiqh and kaedah- fiqh principles.
Región y Nación. La construcción provincial de Chile. Siglo XIX
Authors: Sosa Vota Silvina
Published: June 2021

Reseña de Región y Nación. La construcción provincial de Chile. Siglo XIX, editado por Armando Cartes Montory, Santiago de Chile: Editorial Universitaria, 2020, 428 páginas.
El dilema identitario de la educación ciudadana frente al actual proceso constituyente en Chile
Authors: Contreras Quiroz Natalia
Published: June 2021

La educación de la ciudadanía es un tema central para los avances políticos y sociales que demanda el actual escenario de proceso constituyente en Chile, surgido del estallido social de octubre de 2019. Este texto se pregunta por la identidad de la formación de la ciudadanía en el entendido de que esta es una política de Estado que ha tenido presencia en nuestro sistema educativo desde los orígenes de la nación. Este trabajo se enmarca en un análisis reflexivo del tipo ensayo expositivo, que busca profundizar en el dilema actual de la educación al integrarse al debate político, no solo como una demanda social, sino que también como una herramienta de formación de la ciudadanía crítica que busque la justicia social.
A Review of Research on Agroecosystem Services Based on Bibliometric Analysis
Authors: Tang Haiying , Huang Guoqin
Published: June 2021

Agricultural ecosystem is one of the most important ecosystems in the world, which provides multiple ecosystem services such as grain production, climate regulation, water conservation and biodiversity. The degradation of ecosystem services has become an important factor that severely restricts the sustainable development of agriculture. Agroecosystem services have become the core and hot topic of ecological research. In recent years, countries and related institutions have been increasing their research on agricultural ecosystem service. Based on Web of Science(WoS) and China Knowledge Resource Integrated (CNKI) databases, the development characteristics and trends of agroecosystem services research were analyzed by bibliometric methods. The results show that: (1) The number of papers on agroecosystem services is increasing, which shows that the research on it is developing. (2) Developed countries are the main research forces in the field of ecosystem services, and the developed countries in Europe and the United States occupy the absolute leading position; China Agricultural University and the University of California in the United States are the main research institutions. (3) At present, eight research hotspots in this field are the study of ecosystem services mechanism, protection management and sustainability, sustainable development, biodiversity, land use and landscape change, value assessment, climate change, sustainable development of agriculture, ecological compensation. From the overall distribution of research hotspots in each period, the international research focuses more on the interdependence between ecosystem services and ecosystem services and human well-being, while the research in China focuses more on ecosystem services assessment. (4) In recent years, there is a big gap between China and foreign countries in the field of ecosystem services research. It is necessary to strengthen cooperation with research institutions in developed countries in Europe and the United States, and further improve the research content, research vision and research methods
The Characteristics of Fish Diversity and Age Structure in Pelus River Area Residency of Banyumas - Indonesia
Authors: Susanto Susanto , Rijal Muhammad Azharul
Published: June 2021

This research was purposed to reveal and discover fish community in Pelus River, Banyumas Residency. It includes: (1) water quality which include physical and chemical parameters and plankton species variation, (2) Fish diversity, (3) Fish age structure was based weight and total length. Research done by survey methods, with purposive random sampling methode. The research was conducted in Pelus River Region of Banyumas Residency, which were location one (upstream of Pelus River), location two (middlestream of Pelus River), and location three (downstream of Pelus River). This Research applied survey method, with purposive random sampling technique. Research was done in eight months which replicated every month, since December 2016 untill May 2017. Result indicated that nesearch fishes caught were as many as 544 fishes divided to 18 Species, eight Family and five Ordo. Water quality factor including aquatic physical and chemical parameters, which were temperature, flowrate, clarity, dissolved oxygen and pH and bilogical parameter (plankton)  variation in Pelus River Banyumas Residency were in good condition and suitable for fish life. Cyprinidae Family found as most variated species and most founded spesies in individual number at Pelus River Banyumas Residency. There were low species diversity, but there weren’t found any dominancies. Fish species diversity in Pelus river low. Age structure shows the condition of fish in Pelus River of Banyumas regency is in a vulnerable condition, so it needs attention in order to conserve fish species. Keywords: Fish diversity, age structure, Pelus river, Banyumas
Aplikasi Berbasis Web untuk Analisis Data Menggunakan Korelasi Bivariat Pearson
Authors: Mustafidah Hindayati , Giarto Wahyu Giri Pambudi
Published: June 2021

Statistika adalah ilmu yang berkaitan dengan tata cara  atau metode pengumpulan data, analisis data, dan interpretasi hasil analisis untuk mendapatkan informasi guna penarikan kesimpulan dan pengambilan keputusan khususnya dalam kegiatan penelitian. Banyak program aplikasi pengolah data seperti SPSS, Matlab, Minitab, dan lainnya. Alat bantu hitung yang efisien menjadi salah satu modal utama yang digunakan oleh pengguna aplikasi agar penelitiannya dapat memperoleh hasil analisis data yang tepat dan dideskripsikan dalam bentuk kalimat ataupun kata-kata. Kebutuhan tersebut menjadi dasar dalam penarikan sebuah kesimpulan. Oleh karena itu, pengembangan aplikasi berbasis web untuk analisis data menggunakan korelasi bivariat Pearson dapat menjadi salah satu solusi. Aplikasi uji statistik ini dikembangkan dengan model sekuensial linier. Penelitian ini menghasilkan sebuah aplikasi uji statistik yang dapat memberikan sebuah kesimpulan yang dideskripsikan berupa kalimat sehingga dapat membantu pengguna dalam memaknai hasil penelitiannya khususnya analisis korelasi bivariat atau yang dikenal dengan korelasi Pearson. Berdasarkan hasil pengujian, program aplikasi yang dikembangkan ini memiliki tingkat akurasi yang sama dengan hasil perhitungan dan analisis data yang dilakukan secara manual maupun dengan menggunakan program SPSS. Dengan demikian, program aplikasi ini bisa dijadikan sebagai salah satu alternatif yang dapat digunakan sebagai alat bantu analisis data berupa korelasi bivariat Pearson. Kata-kata kunci: Analisis data, korelasi bivariat, Pearson, sekuensial linier, aplikasi berbasis web
Pengobatan Lele Dumbo (Clarias gariepinus L.) yang Terinfeksi Aeromonas hydrophila di Kabupaten Banyumas dengan Menggunakan Ekstrak Daun Api-Api (Avicennia marina)
Authors: Mulia Dini Siswani , Vauziyyah Syiva
Published: June 2021

Aeromonas hydrophila merupakan salah satu bakteri patogen yang sering menginfeksi lele dumbo (Clarias gariepinus L.) dan menyebabkan penyakit motile aeromonas septicemia (MAS) atau dikenal dengan aeromoniasis. Penyakit ini dapat menyebabkan gagal panen dan menimbulkan kerugian yang sangat besar pada budidaya ikan tersebut. Tujuan penelitian ini adalah mengkaji pengobatan lele dumbo yang terinfeksi bakteri A.hydrophila di Kabupaten Banyumas dengan menggunakan ekstrak daun api-api (Avicennia marina). Penelitian menggunakan metode eksperimen dengan rancangan acak lengkap (RAL), yang terdiri atas 4 perlakuan dan 4 kali ulangan. Perlakuan berupa konsentrasi pemberian ekstrak A.marina, yaitu P0=tanpa pemberian ekstrak daun A. marina, P1= konsentrasi ekstrak daun A. marina 0,2 g/L, P2= konsentrasi ekstrak daun A. marina 0,3 g/L, dan P3=konsentrasi ekstrak daun A. marina 0,4 g/L. Pengobatan ikan dilakukan secara rendaman. Proses recovery diamati selama 30 hari setelah pengobatan. Parameter utama dalam penelitian adalah perkembangan penyakit, proses recovery, sintasan, pertambahan berat ikan, dan panjang ikan. Parameter pendukung dalam penelitian, yaitu suhu, pH, dan kadar O2 terlarut. Data sintasan dianalisis menggunakan Analisis of Variance (anova) dan dilanjutkan dengan menggunakan uji Duncan Multiple Range Test (DMRT) pada taraf uji 5%. Hasil penelitian menunjukkan lele dumbo yang diobati dengan menggunakan ekstrak daun A. marina mengalami penyembuhan pada hari ke-12, sedangkan kontrol pada hari ke-30. Hasil analisis data sintasan menunjukkan P0 berbeda nyata (P<0,05) dengan P1, P2, dan P3. Konsentrasi ekstrak A. marina yang paling efektif dan efisien pada penelitian ini adalah 0,2 g/L (P1). Kata-kata kunci: Aeromonas hydrophila, Avicennia marina, Banyumas, ekstrak, lele dumbo
Pengaruh Regenerasi Kota Terhadap Kualitas Lingkungan Permukiman Industri Kecil Batik Studi Kasus: Kawasan Pabean, Kota Pekalongan
Authors: Sucahyo Hari , Pradoto Wisnu
Published: June 2021

The development of Pekalongan city is rapidly due to its strategic location in the northern coast of Java and the establishment of a world heritage of Batik, so that it gives an influence on all aspects, especially social and economic. Pabean as one of the centers of the home-based batik industry in Pekalongan also played a role in the development of batik, but the existence of the tidal disaster coupled with the lack of conscious entrepreneurs in waste processing has made settlements at customs in a declining environmental quality. Regional recovery programs have been present with the aim of returning the function of settlement infrastructure and facilities in Pabean. This study seeks to examine how much influence the urban regeneration has on the quality of the residential environment in Pabean. by using multiple linear regression analysis using three independent variables which are the concept of urban regeneration, namely social relations of the community, participation of the private sector and the government in maintaining environmental quality, and the relationship between the public and private sector and the government towards the dependent variable of the quality of the settlement environment is obtained by the effect of 14, 29 percent.Keywords: urban regeneration, pekalongan, batik, Pabean
Evaluasi Kampung Kota Berkelanjutan Melalui Pendekatan Asian New Urbanism (Studi Kasus: Kampung Jambangan Kota Surabaya)
Authors: Rukmana Siti Nuurlaily , Sucipto Sucipto
Published: June 2021

The success of the Jambangan Village as one of the best environmental management icons in Surabaya city and as a village that has won an award as the Best of the Best Category in 2011 became a unique phenomenon to be studied. To evaluate the preservation of the Jambangan Village, this study used the Asian New Urbanism Approach. This approach was chosen because it is seen from the suitability of the life behavior of East Asian people who have a yard in each of their houses even with minimal land conditions. There were two aspects examined in this study, including evaluating the existence of Jambangan Village with the Asian New Urbanism approach and followed by analyzing the model of sustainable villages. The method used was descriptive qualitative and evaluative with percentage analysis and triangulation analysis techniques. The results obtained showed that Jambangan Village has implemented a model of sustainable village with the Asian New Urbanism approach of 80%, while the model of sustainable village of Jambangan Village is called the “Kampong Improvement Model”, which has 5 important points, consisting of the provision of space for economic activities, suitability of spatial use and policies, capital spread towards the society, cooperation for the improvement of the quality of the village, and socialization for the improvement of the quality of human resources Keywords: Asian New Urbanism, Sustainable Village, Triangulation
ANALISIS FAKTOR PENDORONG DAN FAKTOR PENGHAMBAT PENGEMBANGAN AGRIBISNIS PERIKANAN TANGKAP DENGAN PENDEKATAN SUBSISTEM DI KABUPATEN PENAJAM PASER UTARA
Authors: Setiawati Novita Putri
Published: June 2021

The marine fishery production of Penajam Paser Utara was 6,045 tons per year of 2018 which was close to the national production number. In addition, fishery is a leading sector after agriculture in PPU which will be developed, the fisheries sector should be able to contribute to a large GDP as well, but this was not in line because seeing the contribution of the fisheries sector to GRDP, constant prices from 2012 to 2016 have decreased by 12,760.03 million rupiah. The purpose of this research is to determine the driving factors and inhibiting factors for the development of fisheries capture agribusiness. This was certainly supported by the direction of Spatial Plans of Penajam Paser Utara Regency in 2011-2031, namely realizing the Regency as the center of agribusiness. The methods used in this research were content analysis to identify driving and inhibiting factors of fisheriescatching agribusiness. The results obtained were as many as 21 variables were the driving factors for agribusiness development and 1 additional variable as an inhibiting factor namely the quality of the Fish Auction Place or TPI. Keywords: Regional Development, Fisheries Capture Agribusiness, Subsystem.
Perancangan Identitas Visual Berbasis Religi Dan Budaya Pesisir Di Kota Demak
Authors: Rochani Agus
Published: June 2021

ABSTRACKThe identity of the city is a form of visual that represents the mental image of the average people. Demak as a city on the north coast of Java Island has much historical value in terms of the spread of Islam. The collaboration between the two aspects is very interesting to expres in the form of a visual identity of the city. This study aims to develop a visual identity design based on the religious values and coastal culture in Demak. The research is formulating qualitatively, which is built from natural basic elements, which depart from data, utilizing existing theories as explanatory material and ending with an identity concept. The design of identity adopts Islamic architectural forms and values at the Great Mosque of Demak, which is collaborated with city characters coast, represented by the shape of sea waves, Islamic ornaments and traditional Javanese Demak Djung boats. Key word: regional image, visual identity, mass composition.  ABSTRAKIdentitas visual kota merupakan wujud visual yang mewakili gambaran mental rata-rata masyarakatnya. Kota Demak sebagai kota yang berada ada di pesisir utara Pulau Jawa memiliki nilai historis yang kuat dalam hal penyebaran Agama Islam. Kolaborasi kedua aspek tersebut sangat menarik dituangkan dalam bentuk indentitas visual kota. Penelitian ini bertujuan menyusun rancangan indentitas visual yang dikembangkan berdasarkan nilai nilai religi dan budaya pesisir di Kota Demak. Penelitian dirumuskan secara kualitatif, yang dibangun dari elemen elemen dasar alamiah, yang berangkat dari data, memanfaatkan teori yang ada sebagai bahan penjelas dan berakhir dengan sebuah konsep identitas. Perancangan identitas mengadopsi bentuk dan nilai arsitektural Islam di Masjid Agung Demak, yang dikolaborasi dengan karakter kota pesisir diwakili oleh bentuk ombak air laut, ornamen Islam dan kapal tradisional Demak Djung Jawa.Kata kunci: citra kawasan, identitas visual, gubahan masa.
KALKULASI KEBUTUHAN UDARA PEMBAKARAN PADA TURBIN GAS PG-9001A SEBAGAI PENYEDIA PANAS UNTUK PEMBANGKITAN STEAM DI HRSG B-9203A BERDASARKAN KONDISI FIRED MODE
Authors: Utama M. Fiqih Alif , , Zulkifli
Published: June 2021

Instalasi Kombinasi (Combyne Cylcle) adalah sebuah proses pembangkitan energi yang menggabungkan turbin gas, yang bertugas membangkitkan energi listrik dan Boiler untuk pembangkitan steam, dimana gas bekas yang keluar dari turbin gas yang masih memiliki enthalpy dan temperatur yang cukup tinggi dimanfaatkan sebagai energi atau udara pembakaran (tambahan burner) pada boiler untuk mengubah air menjadi uap (steam). Pengamatan ini bertujuan untuk menghitung  seberapa besar kontribusi gas buang dari turbin  terhadap efisiensi dari boiler melalui perhitungan neraca massa dan neraca energi dari gas buang dan air umpan boiler. Perhitungan kebutuhan udara pembakaran pada turbin menjadi salah satu hal yang penting guna melihat seberapa besar laju alir massa dari gas buang dan pengaruhnya terhadap pengoptimalan panas pada HRSG. Dari hasil perhitungan didapat kebutuhan udara pembakaran  pada  turbin  sebesar  72.668,2657  Kg/h  dan  pada  burner  sebesar 3.862,6548  Kg/h,  sehingga  total  laju  aliran  massa  gas  buang  didapat  sebesar 279.787,7544 Kg/h, untuk total laju aliran energi panas gas buang turbin dan burner yang diberikan terhadap HRSG sebesar 268.980.660,5674 kJ/h dengan laju aliran energi panas yang diterima HRSG sebesar 201.081.031,4 kJ/h dan besar panas yang hilang mencapai 67.899.629,1674 kJ/h. Sehingga didapatlah efisiensi HRSG berdasarkan kondisi fired mode sebesar 74,76 %.Keyword : Boiler, Burner, HRSG, Steam dan Turbin.
EVALUASI PROGRAM PENINGKATAN KOMPETENSI GURU MADRASAH IBDTIDAIYAH PADA DIKLAT PENYUSUNAN RPP DI BALAI DIKLAT KEAGAMAAN MEDAN
Authors: Safaruddin Safaruddin , Wijaya Candra , Ali Rahmadi
Published: June 2021

This research was conducted at the Balai Diklat Keagamaan Medan with the aim of evaluating the Madrasah teacher competency improvement program in substantive technical training for the preparation of the RPP for Madrasah Ibtidaiyah Teachers. This type of research is qualitative research using the CIPP (context, input, process and product) evaluation model which focuses on core questions, namely the context of the Madrasah teacher competency improvement program, the input conditions for the Madrasah teacher competency improvement program, the process conditions for the improvement program. Madrasah teacher competencies and product conditions in the Madrasah teacher competency improvement program. The results of this study consisted of 4 components. First. The context dimension is the analysis of the legal basis criteria, that every education and training must have a legal umbrella including Regulation of the Minister of Religion 10 of 2018 concerning amendments to PMA No. 59 of 2015 concerning the Organization and Work Procedure of the Education and Training Center and the Criteria for the Analysis of the Education and Training Organization, that the education and training organization that manages the education and training activities has a legal basis and also has a legal basis at work, the education and training organization is a transition of responsibility from the Kasi to the training committee. Educational and Religious Technical Staff were then given a Letter of Appointment (SK).
Genome-wide association studies promise to discover novel indicators of hypertension. Endothelin-related SNPs are currently in clinical trials
Authors: Dowaidar Moataz
Published: June 2021

Nevertheless, in the field of hypertension genomics, it is likely that new genetic markers will be identified, but until they are, the results are restricted. Following on from this, and by drawing from pharmacogenomic, pleiotropic, and functional studies, the follow-up and clinical translation of these genetic results seems to be very promising. These endothelin-related SNPs, which have gone on to the clinical trial stage, signify further success in the advancement of hypertension precision medicine that has already been discovered through genetic research. Although the use of polygenic risk scores may appear advantageous, further study is required to verify their effectiveness, and this issue must be examined further to determine the potential for these scores to lead to an increase in health inequity.
lncRNAs are upregulated and downregulated in OS cells. Angiogenesis, metastasis, cell signaling, autophagy, and death are among biological processes that RNAs play a role in
Authors: Dowaidar Moataz
Published: June 2021

Many lncRNAs are elevated and downregulated in osteosarcoma (OS) cells. These RNAs are involved in a variety of biological processes, including angiogenesis, metastasis, cell signaling, autophagia, and death. In this paper, we give a concise rundown of the lncRNAs that are abnormally expressed in CDDP-resistant OS cell lines. The manipulation of influx/efflux transporters, apoptosis escape, interference in DNA repair mechanisms, autophagy triggered by therapy, and the control of cell signaling pathways appear to be essential mechanisms implicated in the chemoresistance of CDDP mediated by lncRNAs. Overexpression of LNC-ROR, OIP5-AS1, NCK-AS1, and NORAD increases drug efflux transporter activity, whereas overexpression of ANRIL and DNAJC3-AS1 and downregulation of NEAT1, LINC00161, and LINC00473 lowers apoptotic activation. Furthermore, elevated levels of SNHG16 are linked to autophagy induction, whereas overexpression of MIR17HG, TTN-AS1, and KCNQ1OT1 is linked to DNA damage repair and cell cycle dysregulation. Finally, Wnt/-catenin modulation is linked to overexpression of MSC-AS1, TUG1, HOTTIP, and OIP5-AS1, and PI3K/AKT promotes OS cancer cell chemoresistance. When taken together, these findings are expected to lead to a better understanding of CDDP chemoresistance in OS patients as well as improved therapeutic options.
The ability to combine multiple mRNA antigens targeting multiple pathogens simultaneously, and the robust immune responses are confirmed in several clinical studies
Authors: Dowaidar Moataz
Published: June 2021

In the last decade, great progress has been made on mRNA vaccines. MRNA vaccines that are well-tolerated and human immunogenic, stable and can be scaled up to hundreds of millions of doses have been produced with advancements in mRNA design, lipid nanoparticles (LNPs) composition and production techniques. The ability to combine multiple mRNA antigens in the same LNP, targeting multiple pathogens simultaneously, the lack of vector immunity, and the robust immune responses confirmed in several clinical studies make mRNA vaccines a disruptive technology that could change the development of vaccines in the coming years. Moreover, as mRNA was recently employed for large-scale vaccination applications, there is still plenty of room for refining and new advances.Ad-vector-based vaccines have also become promising immunization platforms. Ad vectors' structural components can be harnessed and modified for enhanced tropism, efficient transduction, and optimal antigen expression, and the structural components of Ad vaccine vectors can be harnessed and modified for enhanced tropism, effective transduction, and optimal antigen expression. Ad vectors can be readily created and mass-produced on a commercial basis, and their potency and stability make single-shot immunizations viable without using a frozen cold chain. Ad vectors' flexibility and promise for present and future vaccination applications is evidenced by their development against many illnesses.The use of biomaterials and engineering to improve vaccine delivery control has shown promise in boosting vaccination efficiency and fine-tuning the responses induced. Taken together, these vaccine science innovations have the potential to overcome many of the shortcomings in traditional vaccination technology, and they will almost probably play a crucial part in developing future known and novel disease vaccines.
Energi
Authors: Okarniatif Andi Assyifa Mappedeceng
Published: June 2021

Tubuh memerlukan energi sebagai sumber tenaga untuk segala aktivitas. Energi diperoleh dari makanan sehari-hari yang terdiri dari berbagai zat gizi terutama karbohidrat dan lemak. Energi yang dipergunakan untuk melakukan pekerjaan, dilepaskan dalam tubuh pada proses pembakaran zat-zat makanan. Dengan mengukur jumlah energi yang dikeluarkan itu dapat diketahui berapa banyak makanan yang diperlukan untuk menghasilkannya (Soediaoetama,2000).
Health Insurance Uptake and Affordability of Care Among Patients with Hypertension in a Federal Teaching Hospital in Southwestern Nigeria
Authors: Ipinnimo Tope Michael , Ibirongbe Demilade Olusola , Omowaye Motunrayo Temidayo , Ajayi Paul Oladapo , Ogunleye Taiwo Samuel
Published: June 2021

This study aims to assess health insurance uptake and affordability of care among patients with hypertension in a Federal Teaching Hospital in Southwestern Nigeria. This was a cross sectional study involving 138 hypertensive patient selected through systematic random sampling technique from the cardiology clinic of a Federal Teaching Hospital. A semi-structured, interviewer administered questionnaire was used to collect data. Analysis was done using Statistical Package for Social Sciences (SPSS) version 21. A significance level of 5% was used. The mean age (standard deviation) of the patients was 57.4 (12.8) years with median (interquartile range) monthly income of ₦46,500.00 (₦55,000.00) [US$129 (US$152.78)]. The health insurance uptake among them was 26.8%. Out of those who had no health insurance cover, 87.2% of them believed it could make their financial burden less and wish to be registered. Hypertensive patients enrolled under health insurance were significantly less likely to face financial difficulty when paying for drugs (p<0.001) and investigations (p<0.001). Additionally, these patients were significantly less likely to deny or defer project(s) in order to pay for their illness (p=0.004) and to have their source of livelihood being negatively affected by this illness (p=0.002). This study found a low health insurance uptake among hypertensive patients, even though most of the patients who had no health insurance cover were ready to enroll. Additionally, health insurance was identified to promote affordability of care among these patients. It is therefore crucial to put in place measures that will increase health insurance coverage among these patients.
Single-gene mutations in mtDNA-associated proteins are unlikely to be the main cause of sporadic Parkinson's disease. Cumulative genetic variation in numerous genes may be important in neurodegeneration and PD risk
Authors: Dowaidar Moataz
Published: June 2021

More than two decades ago, numerous individuals with mitochondrial abnormalities and Parkinson's disease were reported. Some of these individuals have mtDNA (mtDNA) mutations, which cause instability. Patients who had neurodegeneration in the SNpc showed that mtDNA abnormalities were important in neurodegeneration and PD risk. Similar findings were found in the MitoPark mice as in PD. Single-gene mutations in mtDNA-associated proteins are unlikely to be the main cause of sporadic PD. The mutation in several genes, functioning in concert in intricate functional networks, results in mild to moderate PD symptoms. Single-gene and PD-GWA studies have had little success in uncovering mtDNA risk loci. In this case, mitochondrial biogenesis and compensation processes are associated with the missing compensatory mechanisms in PD. Maintaining a source of wild-type mtDNA helps to fight age-related development of mtDNA abnormalities. PD risk may be enhanced by increasing age-related neuronal loss, if dysregulated or inhibited.Additionally, PD genes, such as PRKN, LRRK2, are multi-taskers. This involves mtDNA participation as well. Some new discoveries connect mtDNA maintenance and mtDNA stress with PRKN/PINK1 PD-mediated inflammation. mtDNA maintenance pathways might potentially be crucial for monogenic PD. How mitochondria can affect monogenic and sporadic kinds of PD is unknown. Continual study only deepens our understanding of the mitochondrial transcriptome. Additionally, mtDNA is known to encode peptides, mRNAs, and small and long noncoding RNAs. These control mitochondrial gene expression, metabolic activity, and stress response. MtDNA mutations impact the nuclear epigenome through creating variations in mitochondrial intermediates that regulate histones. Additionally, mitochondrial DNA polymerases are present. This creates brand-new possibilities for mtDNA replication and repair. We have identified evidence that nDNA that codes for and/or regulates mitochondrial related activities may add to Parkinson's disease (PD) risk. Cumulative genetic variation in numerous genes (including the NRF-1 and NRF-2 pathway) may be important in neurodegeneration and PD risk. It will need more research to figure out which mtDNA gene mutations are responsible for increasing PD risk.The gradual loss of dopaminergic neurons in the substantia nigra pars compacta is one of the defining characteristics of Parkinson's disease (PD) (SNpc). Rigidity, tremor, and bradykinesia are preceded by hallucinations and sleep difficulties as a result of nigrostriatal dopamine depletion. Symptoms vary greatly and their presence and intensity fluctuate over time. Parkinsonism is a catch-all name for a variety of neurological illnesses, including PD, that can cause symptoms that mimic PD. Parkinsonism instances that lack all of the essential symptoms are referred to as parkinsonism instances.
Kebutuhan Energi Gizi Dalam Tubuh
Authors: Hadza Roza Qoni
Published: June 2021

Tubuh memerlukan energi sebagai sumber tenaga untuk segala aktivitas. Energi diperoleh dari makanan sehari-hari yang terdiri dari berbagai zat gizi terutama karbohidrat dan lemak. Energi yang dipergunakan untuk melakukan pekerjaan, dilepaskan dalam tubuh pada proses pembakaran zat-zat makanan. Dengan mengukur jumlah energi yang dikeluarkan itu dapat diketahui berapa banyak makanan yang diperlukan untuk menghasilkannya (Soediaoetama,2000).Kebutuhan energi seseorang adalah konsumsi energi dari makanan yang diperlukan untuk menutupi pengeluaran energi seseorang bila ia mempunyai ukuran dan komposisi tubuh dengan aktivitas yang sesuai dengan kesehatan jangka panjang dan yang memungkinkan pemeliharaan aktivitas fisik yang dibutuhkan secara sosial dan ekonomi.
RNA therapies hold great promise for treating cancer. High-throughput screening techniques have facilitated the development of RNA treatments
Authors: Dowaidar Moataz
Published: June 2021

High throughput screening techniques have facilitated the creation of RNA treatments, and these findings have been accompanied by unique modifications of RNA structures to increase stability and minimize toxicity, as well as innovative delivery systems such as LNPs. "undruggable" targets, "swiftly construct vaccinations," and to provide therapeutic approaches that can be tailored to individual patients Like the genetic code, RNA therapies hold great promise.At the same time, our hospital launched a specialized RNA Therapeutics program that assists both our internal scientists and external academic groups or small firms aiming to apply their fundamental research discoveries to innovative treatments. mRNA is primarily stable because of our primary study in sequencing and structure. For synthesis, purification, and validation of RNA constructs, we have a contemporary GMP program with clean rooms. Our company collaborates with Nanomedicine to build LNP structures that transport mRNA constructs locally and systemically. We have an opportunity to hire and integrate first-in-man clinical trials unit, as well as a big hospital system with a clinical research infrastructure that enables industry-sponsored Phase 2 and 3 clinical trials. Additionally, we have a large-scale mRNA construction industrial sponsor for Phases 2, 3, and commercialization. Essentially, we've put up a production line for universities and small firms interested in turning their mRNA creations into revolutionary medications. One hospital, one point of entry to ensure that RNA-based drugs are created and translated into the clinic efficiently. Many tiny firms with fresh concepts for disruptive mRNA therapeutics cannot reach the clinic without new translational capabilities. We think we are the only academic organization with the infrastructure to help small academic groups and biotech enterprises, and we want to aid both internal and external translational activities in the coming years.
Kebutuhan Energi Dalam Tubuh
Authors: awalia Widya
Published: June 2021

ebutuhan energi seseorang adalah konsumsi energi dari makanan yang diperlukan untuk menutupi pengeluaran energi seseorang bila ia mempunyai ukuran dan komposisi tubuh dengan aktivitas yang sesuai dengan kesehatan jangka panjang dan yang memungkinkan pemeliharaan aktivitas fisik yang dibutuhkan secara sosial dan ekonom
Synuclein is a protein that is expressed in brain tissue. The specific missense mutation (SNCA) found in a family with Parkinson's disease is the cause. Other diseases include Alzheimer's disease and REM sleep behavior disorder
Authors: Dowaidar Moataz
Published: June 2021

Synuclein is a protein that is expressed in brain tissue. The specific missense mutation (SNCA) found in a family with Parkinson's disease is the cause. Other diseases which have-syn nuclein aggregates include Alzheimer's disease and REM sleep behavior disorder (RBD). All three proteins have well-conserved amino-terminal domains. Central and peripheral nervous system alpha-synuclein is present. Mendelian disease results from mutations in the SNCA genes. The expression of SNCB is more localized to the brain, as is the expression of SNCA. Though substantia nigra is SNCG's largest expression, Parkinson's disease shows it far less. MDSgene classifies four SNCA missense variants as definitely pathogenic. Pathogenicity for two mutations formerly linked to PD is no longer clear. It is clear that polymorphism in the Synuclein alpha gene plays a function in all synucleinopathies. Depending on the variations and illnesses, its role will alter. PD, PDD, and DLB Synuclein alpha mutations have been extensively documented. MSA and PAF are exceptions; thus far, mutations in sickness have been examined in relation to another trait. Similarly, the connection between genetic risk factors and PD, DLB, and PDD/MSA is clear, but uncertain for PAF.Soon, whole-genome sequencing in PD and other synucleinopathies will allow for the detection of further disease-related variants. More research will be required, but the significance of these findings is unclear.To comprehensively comprehend the common and specific pathophysiological mechanisms of synucleinopathies, we will have to integrate genetic tools with biochemical, biophysical, and structural research.
The vasoconstrictor endothelin system involvement in chronic kidney diseases pathogenesis is now the most often employed treatment method
Authors: Dowaidar Moataz
Published: June 2021

Over 30,000 publications have been published about the vasoconstrictor endothelin-1, which was identified by Yanagisawa and co-workers in 1988. While the evidence is quite compelling, scientists can only speculate on how the endothelin (ET) system affects blood pressure and renal function at this time. ET system involvement in chronic kidney diseases (CKD) pathogenesis is now the most often employed treatment method. ET1, ET2, and ET3 are all members of the endothelin family. Endothelium, renal, and smooth muscle cells all generate ET-1, a significant isoform found in both cardiovascular and renal systems.Kidney cells act on, and contain, ET-1. The ETA receptor is found in the brain and medulla, but not in the vasa recta or glomeruli. Epithelial and endothelial cells contain the ETB receptor, which is most prominent in collecting duct cells. 3 In several experiments, ET-1 has been established to be largely a preglomerular vasoconstrictor. Mesangial proliferation, contraction, and collagen production are regulated by ET-1 and ETB receptors in podocytes. The epithelium in the collecting duct cells in the medulla is important in controlling Na excretion and BP. Without the ET-1 gene, the mice have hypertension and reduced natriuresis in response to salt loading. Et-1, ETB receptor, and hypertension are shown in mice that have lost the ETB receptor gene. There is no correlation between blood pressure regulation and natriuresis.Combined disruption of the ETA and ETB receptors has greater effects on blood pressure and Na reabsorption than when ETB receptor activity is missing. It appears that the ETB receptor doesn't work until ETB is present. Collecting duct-derived ET receptors reduces the transport of sodium. Src kinase and MAPK1/2 decrease epidermal Na channel (ENaC) function, decreasing water and salt reabsorption. Moreover, inner medullary collecting duct cells and vasa recta-bearing cells will release NO, which decreases sodium transport.
Glioblastoma therapeutic approaches were established utilizing contemporary discoveries in delivering medicines to the brain as smart nanoparticles for focused therapy
Authors: Dowaidar Moataz
Published: June 2021

The blood-brain barrier (primary) and the blood-brain tumor barrier (secondary) are the main barriers for Glioblastoma (GBM) treatment options. Brain design is connected to a critical barrier that restricts medicine delivery to a specific brain region, leaving the rest of the brain without therapeutic chemicals. This requires moving to a different treatment strategy to reach effective therapeutic concentration in brain tumor tissue. Due to more accurate controlled release of medication to the affected area, a continual shift from standard treatment to targeted administration of medication to the brain is attracting more attention these days. GBM's therapeutic approach was established utilizing contemporary discoveries in delivering medicines to the brain as smart nanoparticles for focused therapy. Better knowledge of molecular mechanisms involved in brain targeting and receptor-based therapeutic potential can boost the therapy results. Nonetheless, the most promising technology is still under development, and continual attempts to infer the fundamental process involved in medication delivery will assist hasten nanoparticles' translation into clinical application. Furthermore, numerous complex nanoparticles, including multifunctional smart nanoparticles, have been created to overcome such challenges for CNS drug delivery and their prospective application has been clinically demonstrated or is in the trial phase.
CAR T cell research has quickly advanced from the bench to the clinic and back. The results of the trials have revealed new mechanisms
Authors: Dowaidar Moataz
Published: June 2021

CAR T cell research has fast progressed into the clinic and now back to the bench, with trial outcomes exposing new mechanisms of efficacy, toxicity, and resistance, and sparking the hunt for additional targets, clarification of signaling systems, and application of newer technology. CAR design, transduction methods, and cell type selection are all predicted to improve responses and change therapy for patients with a variety of malignancies.
Osteoporosis is a prominent source of morbidity and mortality in the elderly, particularly in postmenopausal women. Long noncoding RNAs (lncRNAs) have been found to be important regulators and possible gene therapy targets
Authors: Dowaidar Moataz
Published: June 2021

Fragility fractures caused by osteoporosis are a prominent source of morbidity and mortality in the elderly, particularly in postmenopausal women. In a number of studies, long noncoding RNAs (lncRNAs) have been found to be important regulators of osteoporosis. The particular mechanisms through which lncRNA affects osteogenesis and osteoclastogenesis, on the other hand, are complicated and unknown. More study is needed in the future to examine how lncRNA expression might be modulated, since this might lead to therapeutic benefits for osteoporosis.
HOSPITALITAS KRISTEN KEPADA WISATAWAN DI TORAJA
Authors: Ratte Febriana
Published: June 2021

Suku Toraja adalah suku yang mempunyai keunikan, yang dimana Suku Toraja mempunyai banyak keunikan dalam suatu adat dan kebudayaannya, hal ini yang membuat para wisatawan tertarik untuk datang mengunjungi suku Toraja. Oleh sebab itu agar para wisatawan dapat betah untuk mengunjungi Toraja, orang Toraja haruslah menunjukan sikap hospitalitasnya. Orang Toraja harus mampu menerapkan sikap hospitalitas Kristen yaitu mampu menerapkan kasih Allah kepada orang?orang yang berkunjung di daerah Toraja, sehingga mereka juga dapat merasa aman dan nyaman dalam berwisata di daerah Toraja
KOMPOSISI GIZI
Authors: Husain Zulfa
Published: June 2021

Zat gizi adalah senyawa dari makanan yang digunakan tubuh untuk fungsi fisiologis normal. Definisi yang luas ini mencakup senyawa yang digunakan langsung untuk produksi energi yang membantu dalam metabolisme (koenzim), untuk membangun struktur tubuh atau untuk membantu dalam sel tertentu. Suatu zat gizi sangat penting untuk organisme dalam kelangsungan siklus hidup dan terlibat dalam fungsi organisme. Berdasarkan jumlah yang dibutuhkan oleh tubuh, zat gizi terbagi ke dalam dua golongan,
THE CONDITION OF SMEs AMID THE COVID-19 PANDEMIC
Authors: Widyadari Aliyya
Published: June 2021

In 2020, COVID-19 begins to hit Indonesia and has hit small and medium enterprises (SMEs) hard, through the resulting economic lockdowns and downturns.