bluuebunny/crossref_metadata_2025 huggingface dataset:
Amino acid composition of low-fat sesame ﬂour and prospects for its use in manufacturing organic products for special purposes
Authors: Yevchuk Y. , Kononenko L. , Voitovska V. , Tretiakova S.
Published: July 2021

The article presents a qualitative assessment and chemical component of sesame ﬂour depending on the color. Enrichment of consumer products to increase the nutritional value of products intended for major populations is extremely important today. Increasing the nutritional value of products using various technological techniques, for example, by adding raw materials of natural origin, in particular, sesame ﬂour is a promising solution of the issueo. This ﬂour contains a large number of nutritious and valuable nutrients. Therefore, the determination of the qualitative content and amino acid composition for further use and combination with other types of raw materials is relevant. The purpose of the research was to study the feasibility of using non-traditional baking raw material of sesame seed ﬂour, evaluation of its amino acid composition for further use in the baking industry in the development of technology for special purpose organic products. The ﬂour of sesame seeds of different colors harvested in 2017–2020 was used for research. The amino acid composition in low-fat sesame ﬂour, depending on the color, allows us to note that the content of essential and substitutable acids on average over the years of research was higher in black ﬂour, and the lowest - in dark brown. The high content of glycine was noted in black sesame – 1.398 g, 0.017 g lower than white, gold – 0.040 g, light brown – 0.058 g and dark brown – 0.082 g. Palmitoleic and oleic (omega-9) represent Monounsaturated fatty acids in sesame low-fat ﬂour. The color of sesame ﬂour has a signifcant effect on their content. Of the polyunsaturated fatty acids, the highest content of linoleic is founding in black – 19.5 g, only 0.2 g less in white and 0.5 g – in gold. Light and dark brown compared to black were lower by 0.8 and 1.1 g, respectively.
Кey words: essential and replaceable amino acids, cealics, hypocalcemia, gluten-free products, color.
The reasons for the decrease in the feld crops yield against the background of ﬂat-cut basic tillage
Authors: Yeshchenko V. , Koval G. , Kalievsky M.
Published: July 2021

The purpose of the research was to establish the reason for the decrease in the productivity of crops grown in the experiments under replacing the main processing of moldboard plowing with ﬂat-cut loosening to appropriate depths based on a review of the literature and our own experiments conducted on podzolized chernozem in a fve-feld crop rotation of soybeans – spring rape – spring wheat – oil ﬂax – spring barley. According to the research data, the average yield of 15 crops decreased by 9.0 % due to such replacement. In our experience, the average yield of spring crops decreased by the same amount. Such a decrease in the yield of crops cultivated in diﬀerent experiments against the background of ﬂat-cut cultivation instead of plowing could not be caused by a deterioration in the physical condition of the soil due to the absence of the latter, sinse in 15 experiments, according to the literature data, the density of the addition of the arable layer of different soils changed only by 0.7 % and the content of agronomically valuable structures – only by 0.1 %, and in our experience – respectively by 2.1 and 1.4 % (towards improvement). The total soil permeability in the arable layer also decreased by 1.9 % in our study due to the use of ﬂatcut tillage instead of fall plowing, while remaining within the acceptable range. Changes in the water regime related to the change in the method of basic soil cultivation could not negatively manifest at the level of productivity of crops cultivated in diﬀerent experiments. In addition, only in fve publications out of 15 the reserves of available moisture in the root layer decreased due to replacing moldboard cultivation with non-moldboard loosening, and in the rest 10 ones they remained unchanged or they increased signifcantly. Therefore, the reserves of soil moisture available against the background of ﬂat-cut loosening were 1.7 % higher in comparison with plowing. In the experiment, the advantage of ﬂat-cut cultivation over plowing in terms of available moisture reserves in a meter layer of soil at the middle and end of the growing season of spring crops increased to 6.1 and 6.4 %, respectively. The average productivity of crops cultivated in crop rotation against the background of ﬂat-cut cultivation was signifcantly (by 9.0 %) lower in comparison with plowing. The reason for this could be almost a third (by 27–31 %) higher infestation of crops after the moldboard-free main autumn tillage.
Key words: fve-feld crop rotation, physical condition of the soil, reserves of available moisture, crops weediness, crop yield.
Inﬂuence of seed pre-sowing treatment with multicomponent treaters on the condition of winter wheat pigment complex in the Southern Steppe of Ukraine
Authors: Klipakova Yu. , Bilousova Z. , Korotka I. , Keneva V.
Published: July 2021

In the conditions of climate change, the existing technologies for winter grain crops growing need constant improvement. Development of the leaf surface and its longest preservation is the main vector of any technology for growing winter wheat, and this issue is especially important in unstable weather conditions. The aim of the research was to establish the inﬂuence of multicomponent and multidirectional seed treaters on the state of pigment complex in the leaves of plants of different winter wheat varieties and its productivity during the growing season. When studying pigment complex in the leaves of winter wheat plants in the vegetative period of development this indicator for Antonivka variety was s fund to be 7.17 mg/g of dry matter, and for Shestopalivka variety – 8.04 mg/g of dry matter on average for the variants. The generative period was noted to have an increase in chlorophyll content for both varieties - it was 8.19 mg/g of dry matter for Antonivka and 8.22 mg/g of dry matter for Shestopalivka variety, which is 14.2 % and 2.2 % more than in vegetative period. The productivity of chlorophylls in the vegetative period of plants growth and development averaged 5.14 mg of dry matter/mg of chlorophyll per day for Antonivka, which is 28.4 % more than in Shestopalivka variety (3.69 mg of dry matter/ mg of chlorophyll) per day). With the beginning of the generative period, Shestopalivka variety was noted to have a more stable pigment complex, which is confrmed by a double increase in chlorophylls productivity compared to the previous period. Thus, the increase in chlorophyll content, depending on the pre-sowing treatment with the preparations, is more active in Antonivka variety, but the quantitative index is dominated by Shestopalivka variety. In arid climates, moderate formation of pigments and preservation of their productivity stabilizes grain maturation process, which was noted for both varieties treated with Lamardor and Lamardor plus Gaucho.
Key words: chlorophyll, winter wheat, seed treater, pigment productivity.
Bakery properties of spelt wheat grain depending on fertilization and storage period
Authors: Lubich V. , Zhelyezna V.
Published: July 2021

The article presents the study results of spelt wheat grain baking properties depending on fertilization and storage period. Europe (huskless) winter spelt wheat variety obtained by hybridization of Triticum aestivum L./Triticum spelta L. was studied. For fertilization, ammonium nitrate, ammonium sulfate, granular superphosphate, potassium chloride were used. Spelt wheat grain was stored for a year without air access at an unregulated temperature regime dry (moisture content during storage – 13.0–13.5 %) in airtight polyethylene sleeves in the conditions of usual storage. It was found that spelt wheat has a high response to the application of nitrogen fertilizers. The protein content increased from 18.6 to 22.8 % in P60K60 + N120 variant. The spelt wheat grain quality varied depending on the storage period. Thus, before storage, the gluten content was 41.1–50.4 % depending on the fertilizer variant. The lowest indicator was in the control variant and for P60K60 introduction – 41.1–41.2 %. In other fertilizer variants, the gluten content was at the level of 49.1–49.9 %. The largest was in P60K60 + N60S70 + N60 –50.4 % variant or 9 % compared to the control. Storage had a positive eﬀect on the gluten content in spelt wheat grain as its content increased signifcantly. It can be explained by the post-harvest grain ripening, in the process of which the protein-proteinase complex changes due to the oxidizing action, oxygen, in particular. Thus, after storage for 30 days, this indicator was 41.8–52.1 % depending on the experiment variant. It was the largest when N60S70 + N60 was applied – 52.1 %, and the smallest in the variant with no fertilizers and with phosphorus-potassium (P60K60) fertilizer – 41.8–42.3 %. These indicators exceeded the gluten content before storage by an average of 1.2 abs. %. The content of protein and gluten-forming fractions is the highest after storage for 90 days. These indicators almost did not change after 180–270 days of storage. After 360 days they decreased to the grain quality indicators before storage. The gluten deformation index increased to 105–108 units of GSI instrument or by 4–8 % depending on the fertilization compared to fresh grain. Gluten moisture content decreased after 30 days of grain storage, and then increased to 68.0–69.8 % after 360 days, depending on the experiment variant. The grain acidity also increased from 3.0 to 4.0–4.1 degrees.
Key words: spelt wheat, fertilization, storage, protein, gluten, dynamics, moisture content, acidity.
Development of biotechnological method for temporary isolation of filled honeycombs to increase the productivity of honey collection and the quality of bee hone
Authors: Bezpalyi I. , Postoіenko V. , Merzlov S. , Postoіenko D.
Published: July 2021

The honey productivity of bee colonies during the bribe from the white acacia was increased by the method of selection of unripe honey from the nest. Empty honeycombs were substituted in their place. On the fifth day of honey collection from white acacia in the families of the research group, a third one with empty combs was placed between two buildings. Between buildings 2 and 3, a bee limiter was placed, allowing worker bees to easily get into building 2, but did not allow them to come back. Sampling of honey, analysis of physical and chemical parameters was carried out according to DSTU 4497: 2005 "Natural honey. Technical conditions" (DSTU 4497: 2005, 2007). The use of a biotechnological technique for the temprary isolation of filled cells with unripe honey to increase the honey yield by an average of 26.6% and preserve the quality of the finished product has been substantiated. At the time of bribe from white acacia, freshly brought nectar contained an average of 23.57% sucrose and 38.95% water. Until the end of the first day of the experiment, under the intense influence of the receiving bees, 13.35% of the water is removed on the product, due to which a rapid increase in the concentration of sucrose occurred.At the final stage of the ninth day of maturation, the bees sealed mature honey with a water content of 16.40%, sucrose - 4.95% and 75.64% monosaccharides. Upon the return of the isolated combs with the immature product to the nest, the bees had access to the product for 3 days, and then on the 4th day they began to seal the cells. Honey in terms of water, monosugar and sucrose content did not differ from the product in the control group of bee colonies.
Key words: honeyripening, bees, sucrose, monosaccharides, whiteacacia, nectar.
Age dynamics of reproductive qualities of sows depending on the duration of the suckling period
Authors: Shvachka R. , Povod M.
Published: July 2021

The article studied the influence of sows' age on their reproductive qualities at the traditional - 28 days and shortened - 21 days duration of the suckling period. It was found that the total number of piglets born increased from the second reproductive cycle to the sixth inclusive. With the traditional duration of the suckling period, the most significant growth was observed during the third, fourth and fifth farrowing (8.0-8.6%), while with a reduced duration of the suckling period, it was significantly lower (3.8-4.9%). and lasted from the third to the fifth reproductive cycle. As sows' reproductive age increased, their fertility increased. Its highest growth in both terms of weaning of piglets was on the third farrowing and then gradually decreased. Sows with a reduced suckling period had a lower increase in fertility throughout reproductive life. The nest weight of piglets at birth increased until the third farrowing and then gradually decreased. With the traditional duration of the suckling period, the intensity of the increase in the nest weight of piglets born at the age of sows is higher compared to analogues in which the lactation period was reduced. Preservation of piglets in sows' nests deteriorated with increasing reproductive age. It worsened less intensely in sows with a reduced suckling period. The number of weaned piglets depended to a greater extent on the age of the sows and to a lesser extent on the length of the suckling period. From the third farrowing, it constantly decreases with increasing age of the sow, regardless of the length of the suckling period. The average weight of one piglet increases with the age of sows from the third farrowing, and its growth is more intense with a reduced duration of lactation. The increase in the weight of the nest of piglets at weaning is most significant for 3-5 farrowings, after which there was a decrease in this indicator for both periods of weaning piglets. A comprehensive assessment of the reproductive quality of sows using indices confirms the increase in sow productivity during the second - fourth reproductive cycle with a gradual decrease during the fifth to sixth farrowing, both in the traditional and reduced duration of the suckling period. It is proved that the sow age factor determines the probable influence on the number of piglets at weaning (9.43 %), their safety (5.56 %), the weight of the nest of piglets at weaning (1.87 %) and fertility (1.65 % ). While the suckling period factor affected the nest weight of piglets at weaning with a force of 28.49 %, the number of piglets at weaning with a force of 0.62 %, the safety of piglets before weaning at 0.19 % and did not affect the fertility of sows.
Key words: sow, reproductive cycle, duration of lactation, fertility, safety, piglet.
Simulation of Structure, Intensity and Track of Super Cyclone Amphan Using High Resolution WRF-ARW Model
Authors: Sarker MMA , Quadir DA , Rashid T , Ahasan MN , Shuvo SD , Meandad J , Rabbani KMG , Fariha TR
Published: July 2021

Bangladesh, one of the most densely populated countries in the world with a density of about 1,265 persons per km2 having a limited land area with high development potential. Being able to accomplish noteworthy achievements in MDGs, Bangladesh is heading towards achieving the targets of the SDGs amid several challenges like high population, resource constraints, poverty etc. This study aims at addressing the challenges and prospect of increasing population density in achieving the SDGs. An exploratory approach has been applied to address how the density of population might influence the achievement of the SDGs. Data on population and other relevant parameters have been identified from census, published documents and articles. The current progress of SDGs attainment shows some of the goals are on track, but more progress could have been achieved unless being hindered by the high density of population. Feeding and providing the basic amenities to this huge population is quite a big challenge with limited resources, in contrast, optimum utilization of the demographic dividend by ensuring effective participation of the young active population in the current development process can also expedite the progress of attainment of SDGs. The adversities of the high density of population can essentially be offset by redistribution of urban population and decentralization of economic activities from major cities. Alongside appropriate and precise policy measures, comprehensive study on quantifying how the density of population is affecting the attainment of SDGs is recommended.

The Dhaka University Journal of Earth and Environmental Sciences, Vol. 8(2), 2019, P 17-23
Modeling of Lightning Events using WRF-derived Microphysical Parameters
Authors: Islam Md Ashraful , Meandad Javed , Shuvo Saurav Dey , Kabir Alamgir
Published: July 2021

Numerical simulation of lightning events in Bangladesh has been carried out by using Weather Research and Forecasting Model with Advanced Research Dynamic solver (WRF-ARW). Three major lightning events have been considered for the case study; Case_1, lightning occurrence in Netrokona district in March 24 2017, Case_2, lightning event in Barishal district in April 23 2017, and case_3, lightning event in Sherpur district in April 29, 2018. The model simulation was run in 9 km and 3 km of horizontal resolution using six hourly NCEP-FNL datasets. Yonsei University (YSU) PBL scheme, Rapid Radiative Transfer Model (RRTM) long-wave scheme for radiation, and Kain-Fritsch cumulus parameterization scheme is used for this study. The obtained results from the simulation could reasonably capture the lightning condition of the atmosphere for all the three cases. The WRF simulation give reasonable agreement with the available observational data with some spatial and temporal variations, for example the Convective Available Potential Energy (CAPE) values observed are 1299 J/Kg, 3150 J/kg, 1221 J/kg and CAPE values simulated are 1618 J/kg, 3275 J/kg and 1023 J/kg for case_1, case_2 and case_3 respectively. The regression analysis of the flash count with the microphysical parameters is also studied. It is found that there is strong correlation between the lightning flash counts with the microphysical parameters. This study will help to understand the lightning better and will help to design a better lightning forecasting system.

The Dhaka University Journal of Earth and Environmental Sciences, Vol. 8(2), 2019, P 41-50
Predictors of Outcome in Intracerebral Hemorrhage and Performance of Hemphill ICH Score and GVS Score
Authors: Islam Mahmudul , Hasan Mashfiqul , Mukherjee Sudipta Kumer , Naznin Jobaida , Islam Rafiqul , Hakim Maliha
Published: July 2021

Background: The outcome of intracerebral hemorrhage (ICH) is gloomy. There are several scoring systems for predicting its outcome.

Objective: The purpose of the present study was to observe the predictors of outcome in ICH patients and to assess the performance of ‘Hemphill ICH score’ and ‘GVS score’.

Methodology: This cohort study involved patients of ICH admitted within 72 hours of acute event in July to December 2017 in the Department of Neurology at National Institute of Neurosciences (NINS) & Hospital, Dhaka, Bangladesh. Clinical and radiological data at admission and in-hospital events were obtained from medical records. Patients who were discharged from the hospital were interviewed at 30th day after event by face to face interview or over telephone. Follow up data was not found for 4 patients.

Results: This study involved 115 patients of ICH [median age 60 years (interquartile range, IQR 50-70); 46% (53/115) female]. In-hospital and 30-day mortality of the ICH patients was 22% (25/115: 95% CI 15-30%) and 38% (42/111; 95% CI 29–48%) respectively. There was almost perfect agreement between Hemphill ICH score and GVS score (p<0.001 and κ=0.862). Kaplan-Meier survival curves of patients with different Hemphill ICH scores revealed significant difference among them; which was also true for patients with different GVS scores (by log-rank test, p<0.001 for both). The area under the curve (AUC) for the Hemphill ICH score to predict mortality was 0.70 (95% CI, 0.60–0.80) and for the GVS score 0.74 (95% CI, 0.64–0.83). In bivariate logistic regression, NIHSS score, GCS score, blood glucose at admission, nosocomial pneumonia, ICH volume, midline shift along with both Hemphill ICH and GVS score were observed to predict mortality at 30 days (p<0.05 for all). In two separate models adjusting for blood glucose and nosocomial pneumonia, every 1-point increase in the Hemphill ICH score and GVS score increases the mortality risk by 2.35 fold (adjusted OR: 2.35; 95% CI 1.33-4.16; p=0.003) and 2.99 fold (adjusted OR: 2.99; 95% CI 1.57-5.72; p=0.001) respectively.

Conclusions: Both Hemphill ICH and GVS score have comparable predicting ability of outcome in ICH. In addition to components of scoring systems, occurrence of nosocomial pneumonia and blood glucose seems important.

Journal of National Institute of Neurosciences Bangladesh, January 2021, Vol. 7, No. 1, pp. 3-9
Evaluation of Child Development Centre Based Intervention for Children with Multiple Disability
Authors: Mahbub Mustafa , Rafiqa Humaira , Begum Dilara
Published: July 2021

Background: Children with multiple disabilities usually have more than one significant disability that may include speech, physical mobility, learning, mental retardation, visual, hearing, and possibly others.

Objective: The purpose of the present study was to evaluate the types of multiple disabilities in children with cerebral palsy and epilepsy and their fate after the intervention.

Methodology: This retrospective observational study was conducted at Dhaka Shishu hospital from January 2011 to Decemberb2011.Children with multiple disabilities were referred to the child development center of Dhaka Shishu Hospital and were assessed for impairments and appropriate intervention done in special clinics.

Result: Out of 540 children 66% were male. 43% of children were age group from 12-23 months. 58% had tetraplegic cerebral palsy (CP) with epilepsy and the second-highest group was diplegic CP with epilepsy 75(14.0%). Among 72 selected children who came in regular follow up, all children had motor disabilities. Cognitive delay, speech delay, vision and hearing impairment were found in 50%, 79%, 58% and 54% respectively. After intervention more improvement was found in motor function (92%).

Conclusion: Intervention in specialized clinics improved the quality of life of children with multiple disability.

Journal of National Institute of Neurosciences Bangladesh, January 2021, Vol. 7, No. 1, pp. 38-41
Clinical Findings of Pelvic Inflammatory Diseases among women in Reproductive Age
Authors: Laizu Ismat Ara , Banu Laila Anjuman , Fayez Fowzia Abul
Published: July 2021

Background: Pelvic Inflammatory disease is a very common gynaecological condition among the women in reproductive age group.

Objectives: The purpose of the present study was to find out the clinical findings of Pelvic inflammatory diseases among the women during reproductive age group.

Methodology: This cross-sectional study was carried out in the Department of Obstetrics and Gynaecology at Mymensingh Medical College Hospital, Mymensingh, Bangladesh from January 2008 to June 2009 for a period of one (01) and a half year. Women who were presented with pelvic inflammatory disease (PID) attended at the OPD of gynecology Department at Mymensingh Medical College Hospital, Mymensingh, Bangladesh were selected as study population. Detailed clinical history of each patient was taken and thorough physical examination was performed.

Result: A total number of 300 cases were recruited. The mean age with SD was 30.3±9.57 years. Majority of the patients had tenderness in the lower abdomen which was 96(64.0%) cases. However, 152(50.7%) patients had vaginal discharge and 34(11.3%) patients had uterovaginal proplapse. However, cervical tear was present in 96(32.0%) cases and chronic cervicitis was present in 138(46.0%) cases.

Conclusion: In conclusion most common clinical feature is lower abdominal tenderness followed by vaginal discharge.

Journal of National Institute of Neurosciences Bangladesh, January 2021, Vol. 7, No. 1, pp. 52-55
Hubungan Lama Hemodialisis dengan Fungsi Kognitif pada Pasien yang Menjalani Hemodialisis Menggunakan Metode Mini Mental State Examination Ditinjau dari Kedokteran dan Islam
Authors: Purnama Suci , Armelia Linda
Published: July 2021

Hemodialisis merupakan terapi pengganti ginjal pada penyakit ginjal kronik. Terdapat data statistik yang berbeda untuk prevalensi gangguan kognitif di Indonesia pada pasien yang menjalani hemodialisis mulai dari 20% - 47%. Penelitian ini menggunakan analitik korelatif dengan desain cross sectional yang dilakukan pada bulan Agustus 2018 di RS Anna Medika Bekasi dengan jumlah sampel sebanyak 102 responden yang diambil dengan cara consecutive sampling. Peneliti melakukan wawancara dengan menggunakan kuisioner Mini Mental State Examination (MMSE). Analisis data dengan menggunakan uji spearman. Fungsi kognitif pasien hemodialisis berdasarkan MMSE didapatkan penurunan fungsi kognitif ringan sebanyak 56 (54,9%), penurunan fungsi kognitif sedang sebanyak 13 (12,7%) dan tidak mengalami penurunan fungsi kognitif sebanyak 33 (32,4%). Hubungan antara lama hemodialisis dengan fungsi kognitif didapatkan p value 0,002. Terdapat hubungan signifikan antara lama hemodialisis dengan fungsi kognitif pada pasien hemodialisis di RS Anna Medika
INTENSITY OF INNOVATION ACTIVITY AND ITS PROGRESSIVITY IN ENTERPRISES IN SLOVAKIA IN THE ERA OF INDUSTRY 4.0
Authors: RICHNÁK PATRIK
Published: July 2021

At present, it is not easy to define and recognise the innovative potential of an enterprise in a market environment. It is about identifying the components, relationships and understanding the concepts, interconnections and achieving the expected economic, social, environmental consequences of introducing and managing innovation. Innovation is associated with increased performance, the creation of new markets and competitive advantage. Enterprises are innovating to defend their existing competitive positions as well as to seek a sustainable competitive advantage. The paper's main goal was to examine the degree of the introduction of innovations in enterprises in Slovakia in the era of Industry 4.0 on the basis of a knowledge base and a questionnaire survey. By applying theoretical knowledge and statistical methods of evaluating the questionnaire survey, we came to potential opportunities for the development of innovation activity in the ongoing fourth industrial revolution in the surveyed enterprises.
POSITIONAL EMPHASIS IN THE MODERN LITERARY TEXT
Authors: HALAUR SVITLANA , SHRAMKO RUSLANA , PEDCHENKO SVITLANA
Published: July 2021

The given article touches upon one of the most relevant in modern psycholinguistics problems of literary cognition of reality by the addresser and perception of his knowledge by the addressee. A positional emphasis has therefore been analysed as a productive way of regulating the reader’s perception of the text information. The research focuses on the relevant exposure of all the traits of lingual units’ actualization and on the further sustainable in-depth description of its linguistic techniques. The investigation grounds on up-to-date methods of literary texts’ analysis, particularly on lingual-poetic interpretation, regulatory structuring as well as on information-content one. The psycholinguistic experiment and the survey likewise the method of gradual scaling as its constituents revealed their productivity.
Measurement of IT Risk Management Maturity Level in CEC Using IT Domain Risk Governance Framework
Authors: Iswahyudi Annas
Published: July 2021

IT Risk Management has long been adopted and implemented in CEC. This is inseparable from the high need for reliable and trusted information technology services at CEC as a government institution that has primary task for eradicating corruption. With a good IT risk management is expected to reduce the impact if the IT risk occurs and impacted to overall business process in CEC. However, up to 15 years after the implementation of IT risk management has never been measured how the level of IT maturity risk management. In this research, Author will use the IT Risk Framework with the risk governance domain approach as a standard IT risk management framework to evaluate the implementation of IT risk management in CEC. The process of evaluating the level of IT maturity is based on the maturity model that has been defined in the IT risk framework.
Implementation of Meltdown Attack Simulation for Cybersecurity Awareness Material
Authors: Chattra Eka , Brillyant Obrin Candra
Published: July 2021

One of the rising risk in cybersecurity is an attack on cyber physical system. Today’s computer systems has evolve through the development of processor technology, namely by the use of optimization techniques such as out-of-order execution. Using this technique, processors can improve computing system performance without sacrificing manufacture processes. However, the use of these optimization techniques has vulnerabilities, especially on Intel processors. The vulnerability is in the form of data exfiltration in the cache memory that can be exploit by an attack. Meltdown is an exploit attack that takes advantage of such vulnerabilities in modern Intel processors. This vulnerability can be used to extract data that is processed on that specific computer device using said processors, such as passwords, messages, or other credentials. In this paper, we use qualitative research which aims to describe a simulation approach with experience meltdown attack in a safe environment with applied a known meltdown attack scheme and source code to simulate the attack on an Intel Core i7 platform running Linux OS. Then we modified the source code to prove the concept that the Meltdown attack can extract data on devices using Intel processors without consent from the authorized user.
Free Open-Source High – Availability Solution for Java Web Application Using Tomcat And MySQL
Authors: Dhanny Dhanny , Atiim Sandi Badiwibowo
Published: July 2021

With the growth of the internet, the number of web applications is also growing. Many web applications are becoming more important to the stakeholders that they cannot afford downtime which can cause loss of revenue, loss of productivity, etc. In the past, only big organizations with deep pocket could afford implement high-availability for their web application, but nowadays there are free open-source software programs that support high-availability feature available to everyone. This research studied the feasibility of implementing high-availability for Java web application system without using commercial software. This research compared the capability of proprietary and free open-source high-availability solution for Java web application based on a simple high-availability design, where a test Java web application was deployed into the environment based on proprietary and free open-source solutions, and tested how well each solution perform when problem occurs. The result showed that the free open-source high-availability solution worked, but not as well as proprietary one. However, the proprietary high-availability solution for database did not perform well, and neither did the open-source one. This research concludes that the free open-source high-availability solution works and thus made high-availability become much more affordable, especially for individual or small organizations with budget constraints.
Sosialisasi Senam Ceria Bersama Ibu-Ibu PKK (Pemberdayaan Kesejahteraan Keluarga) Dalam Menyambut Hari Olahraga Nasional
Authors: Indah Eka Purnama , Anggara Norma , Pratiwi Endang , Prayoga Hegen Dadang
Published: July 2021

Senam Kebugaran Jasmani adalah rangkaian gerakan senam yang bertujuan untuk meningkatkan atau mempertahankan kebugaran jasmani. Sesuai dengan kaidah dan ciri-ciri Senam Kebugaran Jasmani (SKJ), gerakan-gerakan direncanakan, disusun secara sistematis, dan bertujuan untuk memperoleh kesehatan dan kebugaran jasmani. Dalam melakukan SKJ selalu diiringi musik yang telah ada. Orang yang bugar berarti sehat secara dinamis. Sehat dinamis menunjang terhadap aktivitas fisik maupun pisikis. Kebugaran yang dimiliki seseorang akan memberikan pengaruh yang positif terhadap kinerja seseorang dan juga akan memberikan pengaruh yang positif terhadap produktifitas bekerja atau belajar. Kebugaran jasmani adalah kesanggupan tubuh untuk melakukan aktivitas tanpa mengalami kelelahan yang berarti dan masih memiliki cadangan tenaga untuk melakukan kegiatan yang lain. Klasifikasi kebugaran jasmani menurut organisasi kesehatan di seluruh dunia diartikan dari kata sehat, adalah terbebasnya tubuh baik fisik maupun mental dari segala penyakit. Bugar adalah kemampuan seseorang untuk melakukan aktivitas sehari-hari secara maksimal, dan masih mempunyai. cadangan tenaga tanpa mengalami kelelahan yag berlebih Senam Kebugaran Jasmani adalah rangkaian gerakan senam yang bertujuan untuk meningkatkan atau mempertahankan kebugaran jasmani. Agar seseorang dikatakan kebugaran jasmaninya baik, maka orang tersebut pada status setiap komponennya harus dalam keadaan baik. Kebugaran jasmani diuraikan menjadi dua golongan yakni komponen kebugaran yang berhubungan dengan kesehatan dan komponen yang berhubungan dengan keterampilan.
Sharing Informasi Pedoman Cuci Tangan Untuk Pencegahan Covid-19 Berbasis Sosial Media Di SD Negeri 88 Palembang
Authors: Laili Reni , Abdillah Leon A. , Yulianingsih Evi , Seprina Iin
Published: July 2021

Teknologi Internet pada masa pandemi saat ini sangat dibutuhkan dan sangat membantu peradaban manusia melakukan semua aktivitas yang mengikuti protokol kesehatan yang diinstruksikan oleh pemerintah yaitu mulai dari social distancing, dilarang berkerumun, penggunaan masker, cara cuci tangan dan penggunaan hand sanitizer yang kesemuanya harus di taati demi menghambat penyebaran wabah virus corona ini. Salah satu cara untuk memutus rantai penyebaran virus Covid-19 , dengan memberikan penyuluhan kepada Masyarakat khsusnya disekolah-sekolah untuk mengetahui pentingnya pedoman cuci tangan yang baik menurut WHO dengan menggunakan QR-Code agar lebih mudah dan efektif untuk mendapatkan informasinya melalui sosial media. Dari Kegiatan Pengabdian Masyarakat yang sudah dilakukan dapat disimpulkan bahwa Semua peserta lebih mengenal bagaimana mendapatkan informasi yang tepat terkait protocol kesehatan pencegahan COVID-19. Dengan menggunakan QR-Qode tentang pedoman cuci tangan, mereka mengetahui langkah-langkah mencuci tangan yang baik dan benara menurut WHO. Dalam pemanfaatan sosial media khususnya Guru-guru dan siswa dapat dengan mudah mencari informasi akurat terkait cara mencuci tangan sesuai dengan protocol kesehatan yang ditetapkan WHO.
The symmetries of quantum and classical information
Authors: Penchev Vasil
Published: July 2021

The paper considers the symmetries of a bit of information corresponding to one, two or three qubits of quantum information and identifiable as the three basic symmetries of the Standard model, U(1), SU(2), and SU(3) accordingly. They refer to “empty qubits”, i.e. those in which no point is chosen (recorded). The choice of a certain point, i.e the certain coefficients of superposition in any qubit, violates those symmetries. It can be represented furthermore as the choice of a privileged reference frame (e.g. that of the Big Bang), which can be described exhaustively by means of 16 numbers (4 for position, 4 for velocity, and 8 for acceleration) independently of time, but in space-time continuum, and still one, 17th number is necessary for the mass of rest of the observer in it.The same 17 numbers describing exhaustively a privileged reference frame thus granted to be “zero”.
Tourism and territorial development: a valid alternative?
Authors: Martin-Merino Mario
Published: July 2021

For at least half a century, tourism has been considered as one of the most useful means to stimulate the socioeconomic development of certain geographical areas that, for different reasons, have not been able to achieve it so far. This consideration of tourism is supported by the World Tourism Organization (UNWTO) as part of the conclusions of the United Nations Conference on Trade and Development held between April 21 and 26, 2012 in Doha (Qatar). Its conclusions recognize the great importance of tourism as a generator of wealth, employment and business opportunities, as well as basic infrastructures in both developing and developed areas. Although the benefits obtained from tourism are obvious, it can also generate unwanted consequences, which have been denounced. Sometimes, and if it is not previously planned, tourism generates more inconveniences than advantages and, it is not always a valid alternative to achieve socioeconomic development.
Preliminary report on climate risk in the Cambridgeshire & Peterborough region, 2020-2099
Authors: Aines Ethan , Simpson Charles , Munro-Faure Amy , Shuckburgh Emily
Published: July 2021

Commissioned by the Cambridgeshire and Peterborough Independent Commission on Climate, this report provides a high-level risk assessment of changes the Cambridgeshire & Peterborough region may experience due to climate change between 2020 and 2099. It examines the interplay between two factors, future overheating and changes in seasonal rainfall patterns, and provides a preliminary overview of some of the major risks associated with these changes. Insight into the changing regional climate is provided through the UK Climate Projection 2018 (UKCP18) data and associated products and research. The region faces at least 42 local risks and opportunities of the 53 national risks referenced in the UK Climate Change Risk Assessment 2017.Of these, the most severe risks faced by the region before 2099 will relate to more extreme summer temperatures and changes in the character of seasonal and annual precipitation.These changes will impact people, the built environment, biodiversity, and the economy.
Using the electromagnetic spectrum
Authors: Accettulli-Huber Manuel , Allwright David , Berman David S. , Campillo-Funollet Eduard , Date Paresh , Gonzo Riccardo
Published: July 2021

We consider the problem of estimating the power and position of an unknown transmitter using only observations on the received power for several sensors, without any directional information. We describe several existing propagation models, and we compute the Fisher in- formation for the free-space loss model. For more complex model, we present some results using a Markov Chain Monte Carlo method, and we describe the application of a particle filter to estimate posterior distributions for the transmitter and channel characteristics.
Human Serum Enhances Biomimicry of Engineered Tissue Models of Bone and Cancer
Authors: Villasante Aranzazu , Robinson Samuel T. , Cohen Andrew R. , Lock Roberta , Guo X. Edward , Vunjak-Novakovic Gordana
Published: July 2021

For decades, fetal bovine serum (FBS) has been used routinely for culturing many cell types, based on its empirically demonstrated effects on cell growth, and the lack of suitable non-xenogeneic alternatives. The FBS-based culture media do not represent the human physiological conditions, and can compromise biomimicry of preclinical models. To recapitulatein vitrothe features of human bone and bone cancer, we investigated the effects of human serum and human platelet lysate on modeling osteogenesis, osteoclastogenesis, and bone cancer in two-dimensional (2D) and three-dimensional (3D) settings. For monitoring tumor growth within tissue-engineered bone in a non-destructive fashion, we generated cancer cell lines expressing and secreting luciferase. Culture media containing human serum enhanced osteogenesis and osteoclasts differentiation, and provided a more realisticin vitromimic of human cancer cell proliferation. When human serum was used for building 3D engineered bone, the tissue recapitulated bone homeostasis and response to bisphosphonates observed in native bone. We found disparities in cell behavior and drug responses between the metastatic and primary cancer cells cultured in the bone niche, with the effectiveness of bisphosphonates observed only in metastatic models. Overall, these data support the utility of human serum for bioengineering of bone and bone cancers.
Human Breast Milk Enhances Intestinal Mucosal Barrier Function and Innate Immunity in a Healthy Pediatric Human Enteroid Model
Authors: Noel Gaelle , In Julie G. , Lemme-Dumit Jose M. , DeVine Lauren R. , Cole Robert N. , Guerrerio Anthony L. , Campbell James D. , Kovbasnjuk Olga , Pasetti Marcela F.
Published: July 2021

Breastfeeding has been associated with long lasting health benefits. Nutrients and bioactive components of human breast milk promote cell growth, immune development, and shield the infant gut from insults and microbial threats. The molecular and cellular events involved in these processes are ill defined. We have established human pediatric enteroids and interrogated maternal milk’s impact on epithelial cell maturation and function in comparison with commercial infant formula. Colostrum applied apically to pediatric enteroid monolayers reduced ion permeability, stimulated epithelial cell differentiation, and enhanced tight junction function by upregulating occludin. Breast milk heightened the production of antimicrobial peptide α-defensin 5 by goblet and Paneth cells, and modulated cytokine production, which abolished apical release of pro-inflammatory GM-CSF. These attributes were not found in commercial infant formula. Epithelial cells exposed to breast milk elevated apical and intracellular pIgR and enabled maternal IgA translocation. Proteomic data revealed a breast milk-induced molecular pattern associated with tissue remodeling and homeostasis. Using a novelex vivopediatric enteroid model, we have identified distinct cellular and molecular events involved in human milk-mediated improvement of human intestinal physiology and immunity.
AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function
Authors: Xie Ruxin , Wang Zhongke , Liu Tianyao , Xiao Rui , Lv Keyi , Wu Chuan , Luo Yi , Cai Yun , Fan Xiaotang
Published: July 2021

Transient Receptor Potential Canonical 6 (TRPC6) has been suggested to be involved in synapse function and contribute to hippocampal-dependent cognitive processes. Gene silencing of TRPC6 was performed by injecting adeno-associated virus (AAV) expressing TRPC6-specific shRNA (shRNA-TRPC6) into the hippocampal dentate gyrus (DG). Spatial learning, working memory and social recognition memory were impaired in the shRNA-TRPC6 treated mice compared to control mice after 4 weeks. In addition, gene ontology (GO) analysis of RNA-sequencing revealed that viral intervention of TRPC6 expression in DG resulted in the enrichment of the process of synaptic transmission and cellular compartment of synaptic structure. KEGG analysis showed PI3K-Akt signaling pathway were significantly down-regulated. Furthermore, the shRNA-TRPC6 treatment reduced dendritic spines of DG granule neurons, in terms of spine loss, the thin and mushroom types predominated. Accompanying the spine loss, the levels of PSD95, pAkt and CREB in the hippocampus were decreased in the shRNA-TRPC6 treated animals. Taken together, our results suggest that knocking down TRPC6 in the DG have a disadvantageous effect on cognitive processes.
Interneuron Heterotopia in the Lis1 Mutant Mouse Cortex Underlies a Structural and Functional Schizophrenia-Like Phenotype
Authors: Garcia-Lopez Raquel , Pombero Ana , Estirado Alicia , Geijo-Barrientos Emilio , Martinez Salvador
Published: July 2021

LIS1 is one of the principal genes related to Type I lissencephaly, a severe human brain malformation characterized by an abnormal neuronal migration in the cortex during embryonic development. This is clinically associated with epilepsy and cerebral palsy in severe cases, as well as a predisposition to developing mental disorders, in cases with a mild phenotype. Although genetic variations in the LIS1 gene have been associated with the development of schizophrenia, little is known about the underlying neurobiological mechanisms. We have studied how the Lis1 gene might cause deficits associated with the pathophysiology of schizophrenia using the Lis1/sLis1 murine model, which involves the deletion of the first coding exon of the Lis1 gene. Homozygous mice are not viable, but heterozygous animals present abnormal neuronal morphology, cortical dysplasia, and enhanced cortical excitability. We have observed reduced number of cells expressing GABA-synthesizing enzyme glutamic acid decarboxylase 67 (GAD67) in the hippocampus and the anterior cingulate area, as well as fewer parvalbumin-expressing cells in the anterior cingulate cortex in Lis1/sLis1 mutants compared to control mice. The cFOS protein expression (indicative of neuronal activity) in Lis1/sLis1 mice was higher in the medial prefrontal (mPFC), perirhinal (PERI), entorhinal (ENT), ectorhinal (ECT) cortices, and hippocampus compared to control mice. Our results suggest that deleting the first coding exon of the Lis1 gene might cause cortical anomalies associated with the pathophysiology of schizophrenia.
A Zinc Metalloprotease nas-33 Is Required for Molting and Survival in Parasitic Nematode Haemonchus contortus
Authors: Huang Yan , Wu Jie , Chen Xueqiu , Tong Danni , Zhou Jingru , Wu Fei , Zhang Hui , Yang Yi , Ma Guangxu , Du Aifang
Published: July 2021

Molting is of great importance for the survival and development of nematodes. Nematode astacins (NAS), a large family of zinc metalloproteases, have been proposed as novel anthelmintic targets due to their multiple roles in biological processes of parasitic nematodes. In this study, we report a well conserved nas-33 gene in nematodes of clade V and elucidate how this gene is involved in the molting process of the free-living nematode Caenorhabditis elegans and the parasitic nematode Haemonchus contortus. A predominant transcription of nas-33 is detected in the larval stages of these worms, particularly in the molting process. Knockdown of this gene results in marked molecular changes of genes involved in cuticle synthesis and ecdysis, compromised shedding of the old cuticle, and reduced worm viability in H. contortus. The crucial role of nas-33 in molting is closely associated with a G protein beta subunit (GPB-1). Suppression of both nas-33 and gpb-1 blocks shedding of the old cuticle, compromises the connection between the cuticle and hypodermis, and leads to an increased number of sick and dead worms, indicating essentiality of this module in nematode development and survival. These findings reveal the functional role of nas-33 in nematode molting process and identify astacins as novel anthelmintic targets for parasitic nematodes of socioeconomic significance.