bluuebunny/crossref_metadata_2025 huggingface dataset:
Failing professional practice placements in allied health: What do we understand about the student experience? A scoping review
Authors: Milgate Wendy , Copley Jodie , Hill Jessica
Published: June 2023

Professional practice placements are an essential component of allied health and nursing programs. Whilst most students pass these placements, a small percentage of students will fail or be at risk of failing. Supporting students undergoing a failing experience is a time critical, time consuming, emotional and resource-heavy task which is often undertaken by key university staff and impacts all stakeholders. Whilst several studies have provided insight into this experience from the educator and/or university perspective, this scoping review aimed to identify the students’ experience of failing or nearly failing a professional practice experience. Following Arskey and O’Malley’s framework for scoping reviews, 24 papers were included in this review. This review generated six themes including the reasons for failure, how failure looks and feels, how supports, service and strategies influence the student experience of failure, the importance of communication, relationships and organisational culture, the impact infrastructure and policies have, and the consequences of failure. The outcomes of this scoping review highlighted three key characteristics of the research to date: (a) the student voice is still largely missing; (b) the student perspective is distinctly different to that of other stakeholders; and (c) the interventions used appear not to be student-informed or student-led. Better understanding this experience from the student’s perspective could create a more sustainable practice education environment by designing and implementing more effective supports, services or strategies that reduce the overall impact a failing experience has on students and key stakeholders.
Betting on the House: The Impact of Gambling on Homeownership in Australia
Authors: Baako Kingsley Tetteh , Mintah Kwabena , Churchill Sefa Awaworyi , Farrell Lisa
Published: June 2023

Gambling is commonly associated with social and economic disadvantage. In this paper we examine the impact of gambling on homeownership, using Australian panel data. We find that gambling is associated with a lower probability of homeownership. Specifically, our endogeneity corrected estimates show that an increase in problem gambling is associated with between 1.6 and 1.8 percentage point decrease in the probability of owning a home depending on the model. Our result show that financial stress and social capital are channels through which gambling influences the probability of homeownership.
The Role of Social Support and Belonging in Predicting Recovery from Problem Gambling
Authors: Penfold Katy L. , Ogden Jane
Published: June 2023

Research indicates a role for both social support and belonging in addiction recovery, however little is known about the role of these constructs in the recovery from problem gambling, and whether they relate to the effectiveness of mutual aid groups such as Gamblers Anonymous. The aim of this study was therefore to explore the relationship between social support and belonging, and to assess the role of demographics (including group membership of GA), social support and/or belongingness in predicting gambling addiction recovery in terms of gambling urges and quality of life. Using a cross sectional design, participants identifying as having problem gambling (n = 60) completed an online questionnaire with two independent variables (Social Support and Belonging), two dependent variables (Gambling Urges and Quality of Life) to assess gambling addiction recovery and measures of GA membership. The results showed no significant association between gender, age, ethnicity, education or employment status and gambling urges or quality of life. Membership to GA, and length of membership were significantly associated with gambling recovery indicating that being a member of GA and longer membership was associated with lower gambling urges and higher quality of life. Further, the results showed a high but not perfect correlation between social support and belonging (r(58) = .81, p =  < .01). A regression analysis showed that although there was a significant correlation between social support and belongingness, they played different roles in gambling addiction recovery. Social support alone predicted higher quality of life, but not a reduction in gambling urges; belonging (along with being a member of GA) predicted a reduction in gambling urges, but not an increase in quality of life. Social support and belonging have a differential impact on aspects of gambling addiction, and should be considered as different constructs. In particular, whilst the process underpinning reduced gambling urges is membership of GA and the sense of belonging it provides its members, social support per se is a better predictor of quality of life. These findings have implications for the development of treatment for problem gamblers in the future.
On the relativistic spatial localization for massive real scalar Klein–Gordon quantum particles
Authors: Moretti Valter
Published: June 2023

I rigorously analyze a proposal, introduced by D.R. Terno, about a spatial localization observable for a Klein–Gordon massive real particle in terms of a Poincaré-covariant family of POVMs. I prove that these POVMs are actually a kinematic deformation of the Newton–Wigner PVMs. The first moment of one of these POVMs, however, exactly coincides with a restriction (on a core) of the Newton–Wigner self-adjoint position operator, though the second moment does not. This fact permits to preserve all nice properties of the Newton–Wigner position observable, dropping the unphysical features arising from the Hegerfeldt theorem. The considered POVM does not permit spatially sharply localized states, but it admits families of almost localized states with arbitrary precision. Next, I establish that the Terno localization observable satisfies part of a requirement introduced by D.P.L. Castrigiano about causal temporal evolution concerning the Lebesgue measurable spatial regions of any Minkowskian reference frame. The validity of the complete Castrigiano’s causality requirement is also proved for a notion of spatial localization which generalizes Terno’s one in a natural way.
New space-efficient quantum algorithm for binary elliptic curves using the optimized division algorithm
Authors: Kim Hyeonhak , Hong Seokhie
Published: June 2023

In the previous research on solving the elliptic curve discrete logarithm problem, quantum resources were concretely estimated. In Banegas et al. (IACR Trans Cryptogr Hardw Embed Syst 2021(1):451–472, 2020. https://doi.org/10.46586/tches.v2021.i1.451-472), the quantum algorithm was optimized for binary elliptic curves, with the main optimization target being the number of the logical qubits. The division algorithm was primarily optimized in Banegas et al. (2020) since every ancillary qubit is used in the division algorithm. In this paper, we propose a new quantum division algorithm on the binary field that uses fewer qubits. Specifically, for elements in a field of $$2^n$$

2
n

, our algorithm saves $$n - 3\lfloor \log {n} \rfloor - 2$$

n
-
3
⌊
log
n
⌋
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2

qubits instead of using $$n^2 - 64n\lfloor \log (n) \rfloor + O(n)$$

n
2

-
64
n

⌊
log

(
n
)

⌋

+
O

(
n
)

more Toffoli gates, which leads to a more space-efficient quantum algorithm for binary elliptic curves. For the small size n of 16, 127, 163, 233, 283 and 571, both the number of qubits and the number of Toffoli gates are actually reduced. When the size n is 571, the reduction in ancillary qubits amounts to approximately 23% compared to the previous algorithm.
Crosslinguistic influence on spelling in written compositions: Evidence from English-Spanish dual language learners in primary grades
Authors: Wolters Alissa Patricia , Kim Young-suk Grace
Published: June 2023

We investigated spelling errors in English and Spanish essays by Spanish-English dual language learners in Grades 1, 2, and 3 (N = 278; 51% female) enrolled in either English immersion or English-Spanish dual immersion programs. We examined what types of spelling errors students made, whether they made spelling errors that could be due to crosslinguistic influence, and whether errors were associated with instructional program, English learner status, and grade level. Compositions were transcribed and coded using the Systematic Analysis of Language Transcripts (SALT) software. Spelling errors were suggestive of crosslinguistic influence that was mostly unidirectional from one language to the other rather than bidirectional. Spelling errors were related to instructional program such that students in Spanish-English dual immersion made more English spelling errors in English compositions due to Spanish influence, and students in English immersion made more spelling errors in Spanish compositions due to English influence. Students in higher grades also made less English spelling errors in English compositions due to Spanish influence than students in lower grades. These findings suggest that dual language learners acquire spelling patterns in one language influenced by instruction and home language, which transfers to spelling in the other language.
Checking in at bee hotels: trap-nesting occupancy and fitness of cavity-nesting bees in an urbanised biodiversity hotspot
Authors: Prendergast Kit S.
Published: June 2023

With urbanisation leading to loss of nesting resources, and increasing public interest in helping bees, bee hotels (trap-nests) are becoming popularised. However, their success is relatively understudied. The influence of habitat type in determining occupancy and emergence is also poorly known. Over two years across 7 bushland remnant and 7 residential garden sites, trap-nests were installed and completed nests collected monthly over spring-summer. Bees appeared to take a month to find the trap-nests, irrespective of month they were installed. A small percentage (13% and 6% in the two years) of tubes were occupied, but this was within the range of other trap-nesting studies. Smaller 4 and 7 mm diameter nests had a higher occupancy rate than 10 mm diameter tubes. An impressive number − 24 bee species – occupied the trap-nests. Representation however was dominated by five species. The species composition (species and their relative abundances) of cavity-nesting bees differed greatly between those using the trap-nests compared with those observed in the field. Bushland remnants tended to have more bee hotels occupied, and male body size of emerged bees was larger in this habitat. Unexpectedly native and total flower diversity reduced bee hotel occupancy, whereas native flower parameters tended to positively influence bee fitness. Overall installing bee hotels can provide additional nesting resources for native bees in urbanised areas, and providing high proportions of native flora in the vicinity should enhance fitness of the bees using them.
The synergistic hydration mechanism and environmental safety of multiple solid wastes in red mud-based cementitious materials
Authors: Zhu Junge , Yue Hongzhi , Ma Laijun , Li Zichao , Bai Rong
Published: June 2023

Red mud (RM) is a solid waste material with high alkalinity and low cementing activity component. The low activity of RM makes it difficult to prepare high-performance cementitious materials from RM alone. Five groups of RM-based cementitious samples were prepared by adding steel slag (SS), grade 42.5 ordinary Portland cement (OPC), blast furnace slag cement (BFSC), flue gas desulfurization gypsum (FGDG), and fly ash (FA). The effects of different solid waste additives on the hydration mechanisms, mechanical properties, and environmental safety of RM-based cementitious materials were discussed and analyzed. The results showed that the samples prepared from different solid waste materials and RM formed similar hydration products, and the main products were C–S–H, tobermorite, and Ca(OH)2. The mechanical properties of the samples met the single flexural strength criterion (≥ 3.0 MPa) for first-grade pavement brick in the Industry Standard of Building Materials of the People's Republic of China-Concrete Pavement Brick. The alkali substances in the samples existed stably, and the leaching concentrations of the heavy metals reached class III of the surface water environmental quality standards. The radioactivity level was in the unrestricted range for main building materials and decorative materials. The results manifest that RM-based cementitious materials have the characteristics of environmentally friendly materials and possess the potential to partially or fully replace traditional cement in the development of engineering and construction applications and it provides innovative guidance for combined utilization of multi-solid waste materials and RM resources.
Impact of vacuum ultraviolet (VUV) photolysis on ethylene degradation kinetics and removal in mixed-fruit storage, and direct exposure to ‘Fuji’ apples during storage
Authors: Mabusela Bongolwethu P. , Belay Zinash A. , Godongwana Buntu , Caleb Oluwafemi James
Published: June 2023

Accumulated ethylene in fruit storage/transportation causes rapid senescence resulting in reduced shelf-life and postharvest losses. The aim of this study was to investigate the application of vacuum ultraviolet (VUV) photolysis modular reactor for fruit storage. The first experiment compared the effectiveness of VUV photolysis reactor with the standard fruit industry adsorbent (potassium permanganate, KMnO4) on the removal of ethylene from mixed-fruit loading of apples, banana, and pears stored at ambient temperature (16 °C) for 6 days. Second study evaluated the impact of direct VUV radiation on quality attributes of apples stored at 10 °C for 21 days. Results showed that ethylene produced in mixed-fruit loading storage significantly (p < 0.05) reduced by 86.9% in the storage chamber connected to VUV modular reactor compared to 25.4% for storage under potassium permanganate. Direct exposure of apples to VUV radiation successfully reduced both ethylene and respiration rate but damaged the skin of the apples. Hue angle and lightness (L*) for apples exposed to VUV radiation declined significantly (p < 0.05) from 60.7 ± 1.09 to 33.5 ± 9.51 and 58.1 ± 3.60 to 50.4 ± 1.13, respectively. This study showed the potential of VUV photolysis as an innovative technique for removing ethylene from storage facility.
Engineer Nanoscale Defects into Selective Channels: MOF-Enhanced Li+ Separation by Porous Layered Double Hydroxide Membrane
Authors: Lu Yahua , Zhou Rongkun , Wang Naixin , Yang Yuye , Zheng Zilong , Zhang Miao , An Quan-Fu , Yuan Jiayin
Published: June 2023

Two-dimensional (2D) membrane-based ion separation technology has been increasingly explored to address the problem of lithium resource shortage, yet it remains a sound challenge to design 2D membranes of high selectivity and permeability for ion separation applications. Zeolitic imidazolate framework functionalized modified layered double hydroxide (ZIF-8@MLDH) composite membranes with high lithium-ion (Li+) permeability and excellent operational stability were obtained in this work by in situ depositing functional ZIF-8 nanoparticles into the nanopores acting as framework defects in MLDH membranes. The defect-rich framework amplified the permeability of Li+, and the site-selective growth of ZIF-8 in the framework defects bettered its selectivity. Specifically speaking, the ZIF-8@MLDH membranes featured a high permeation rate of Li+ up to 1.73 mol m−2 h−1 and a desirable selectivity of Li+/Mg2+ up to 31.9. Simulations supported that the simultaneously enhanced selectivity and permeability of Li+ are attributed to changes in the type of mass transfer channels and the difference in the dehydration capacity of hydrated metal cations when they pass through nanochannels of ZIF-8. This study will inspire the ongoing research of high-performance 2D membranes through the engineering of defects."Image missing"
Towards Practical Application of Li–S Battery with High Sulfur Loading and Lean Electrolyte: Will Carbon-Based Hosts Win This Race?
Authors: Gong Yi , Li Jing , Yang Kai , Li Shaoyin , Xu Ming , Zhang Guangpeng , Shi Yan , Cai Qiong , Li Huanxin , Zhao Yunlong
Published: June 2023

As the need for high-energy–density batteries continues to grow, lithium-sulfur (Li–S) batteries have become a highly promising next-generation energy solution due to their low cost and exceptional energy density compared to commercially available Li-ion batteries. Research into carbon-based sulfur hosts for Li–S batteries has been ongoing for over two decades, leading to a significant number of publications and patents. However, the commercialization of Li–S batteries has yet to be realized. This can be attributed, in part, to the instability of the Li metal anode. However, even when considering just the cathode side, there is still no consensus on whether carbon-based hosts will prove to be the best sulfur hosts for the industrialization of Li–S batteries. Recently, there has been controversy surrounding the use of carbon-based materials as the ideal sulfur hosts for practical applications of Li–S batteries under high sulfur loading and lean electrolyte conditions. To address this question, it is important to review the results of research into carbon-based hosts, assess their strengths and weaknesses, and provide a clear perspective. This review systematically evaluates the merits and mechanisms of various strategies for developing carbon-based host materials for high sulfur loading and lean electrolyte conditions. The review covers structural design and functional optimization strategies in detail, providing a comprehensive understanding of the development of sulfur hosts. The review also describes the use of efficient machine learning methods for investigating Li–S batteries. Finally, the outlook section lists and discusses current trends, challenges, and uncertainties surrounding carbon-based hosts, and concludes by presenting our standpoint and perspective on the subject.
Justice for Children in Ghana: The Untold Dimension
Authors: Marfo Samuel , Aniagyei Wilson , Bamaora Florence Naah
Published: June 2023

Studies on criminal justice in Ghana have implicated the police in bribery, breach of trust, crime trade, and brutality, among others. This study departed from the approach of “perceived wrongs” cited against the police and examined the less untold challenges which militate against child-friendly policing in the country. A total of 160 police respondents were randomly selected from three police districts in the Northern Region of Ghana in a correlational study design. Administering a questionnaire was used as the primary data collection method. The study found that the police are constrained by inadequate cells for juveniles, inadequate serviceable vehicles, lack of remand homes for juveniles, lack of State-owned temporary shelters for victims of abuse and inadequate budgetary support for handling juvenile crimes. Using Kendall’s coefficient of concordance, with a 147.119 (df = 5) value for χ2, the asymptotic significance (p) was 0.000, signifying a significant agreement among police officers’ grading scores. Kendall’s coefficient of concordance (W) figure was found to be 0.751, implying that 75.1% of the ranking scores given by police officers were in consonance with these challenges which have restrained them from any practical child-friendly policing and administration of juvenile justice in the study locality.
Access to justice and the role of parliamentarians: what happens to those who fall through the justice gap?
Authors: Newman Daniel , Robins Jon
Published: June 2023

This is the first academic paper to consider the role that parliamentarians play in access to justice. Under austerity, England and Wales has seen cuts to legal aid and local authority budgets that have impacted the ability of people to get help for legal problems in social welfare law from the advice sector. Members of the UK Parliament and Members of the Senedd Cymru are increasingly being called upon by their constituents to fill the resultant gap in advice. This paper draws on interviews with parliamentarians that draw out the nature of the role they are now playing in access to justice across three key areas of civil justice: welfare benefits; housing; and immigration. The growth of parliamentarians as figures in access to justice has thus far been largely neglected but is crucial to grasp, as the implications for the future of access to justice are massive. The paper calls for more research to better understand the phenomenon but urges caution that elected representatives should not be considered as an adequate substitute for a properly functioning, adequately funded advice sector.
THE ROLE OF COURTS IN PLASTIC POLLUTION GOVERNANCE
Authors: Varvastian Samvel
Published: June 2023

Plastic pollution is a planetary crisis posing a significant threat to humans and the environment. The regulatory response to this crisis has so far been piecemeal and has not prevented the accumulation and ubiquity of plastic pollution. The growing concern over plastic pollution and the first regulatory measures directed against it soon resulted in court cases. By early 2023, cases concerning plastic pollution emerged in more than 30 countries around the world. From holding private polluters accountable to considering the constitutionality of restrictions on certain plastic products and to ordering regulatory bodies to adopt or implement such measures, courts are playing an increasingly important role in plastic pollution governance.
The New Liberals and Chinese Civilization: Idealist Philosophy, Evolutionary Sociology, and the Quest for a Humanitarian Ethics in Edwardian Britain
Authors: Lee Charles C. H.
Published: June 2023

It is well known that the leading New Liberals L. T. Hobhouse and J. A. Hobson were critics of the British Empire, and their sympathy with China has been understood as an expression of their anti-imperialism. However, this article argues that this reading is at best one-sided. By examining Hobhouse's and Hobson's ethical and sociological thought, it demonstrates that their Sinophile position drew on a broader concern about the turn-of-the-century moral crisis. Informed by Idealist philosophy, positivism, and evolutionary biology, their quest for a post-Christian ethics led to an appreciation of the harmonic order of Chinese society and its secularism. The leading New Liberals’ earnest study of China on the one hand represented a departure from the Eurocentric position of British Liberals who had seen “stationary” China as a negative object lesson, and on the other anticipated a generation of Liberal/progressive thinkers who were attracted to Chinese culture.
Die Rolle der Ernährung für die Muskelgesundheit im Alter
Authors: Fischer Andreas M. , Kressig Reto W.
Published: June 2023

Zusammenfassung: Die altersmedizinisch veränderte Bedeutung der Ernährung für die Muskelgesundheit beginnt ab dem 50. Lebensjahr. Die Alterung des Bewegungsapparats ist aufgrund ihrer Auswirkungen auf die Mobilität und körperliche Selbstständigkeit älterer Menschen eine der grössten Herausforderungen und Aufgaben für die öffentliche Gesundheit einer sich im demografischen Wandel befindenden Schweiz. Insbesondere die Sarkopenie, eine über altersassoziierte Veränderungen hinausgehende pathologische Abnahme der Muskelkraft, Muskelmasse und Muskelfunktion, korreliert mit einem deutlich erhöhten Sturzrisiko sowie einer zunehmenden Morbidität und Mortalität. Im Alter gehäufte chronische Krankheiten begünstigen nicht nur den Muskelabbau, sondern fördern auch die Gebrechlichkeit, was zu einer zusätzlichen Beeinträchtigung der Lebensqualität führt. Hausärztinnen und Hausärzten kommt bei der Ersteinschätzung sich verändernder Lebensumstände und Aktivitätsprofile älterer Menschen eine besondere Rolle zuteil. Dank einer meist jahrelangen Betreuung können sie funktionelle Einbussen ihrer älter werdenden Patientinnen und Patienten frühzeitig identifizieren und rechtzeitig adressieren. Dies ist umso wichtiger, als hier mit einer einfachen Kombination aus proteinreicher Ernährung und körperlichem Training äusserst wirksam interveniert werden kann. Proteinreicher zu essen (unter Berücksichtigung des neu deutlich nach oben korrigierten täglichen Proteinbedarfs für gesunde Senioren von 1,0–1,2g/kg Körpergewicht (KG)) kann dabei den altersassoziierten Muskelabbau bereits massgeblich verlangsamen. Je nach Alter und Komorbiditäten liegt der tägliche Proteinbedarf noch höher (1,5 bis 2,0g/kg KG). Dabei empfiehlt es sich gemäss aktueller Studienlage, für eine optimale muskelwachstumsstimulierende Wirkung der Proteine pro Hauptmahlzeit die Menge von 25–35g nicht zu unterschreiten. Eine besondere Rolle kommt der Aminosäure L-Leucin und entsprechend L-Leucin-reichen Lebensmitteln zuteil, die ganz spezifisch die myofibrilläre Proteinsyntheserate zu steigern vermögen und somit einen begünstigenden Einfluss auf die Muskelgesundheit im Alter ausüben.
Classification of IR Images of Small Eruptions at the Erebus Volcano, Antarctica, With Zernike Moments and Support Vector Machine
Authors: Honarbakhsh L. , Morra G.
Published: June 2023

To investigate the explosive nature of the Erebus volcano, Antarctica, millions of infrared images of the Ray lava lake were analyzed to identify time and position of non‐explosive small eruptions (NESEs). We developed a new technique based on two steps: (a) feature recognition using Zernike moments of the IR images and (b) classification using Support Vector Machine (SVM) applied to Zernike moments. Measures of the performance score were at least higher than 97% via different metrics for different categorization tasks. We observed distinctly different Zernike spectrums between NESEs and no‐eruption images. In the three months with the best quality images (December 2013, December 2014, and January 2015), out of about one million images per month, 654, 405, and 3,650 NESEs were detected, respectively. Using k‐means clustering three activity regimes emerged: low (≤4 NESEs per hour), intermediate (4 <NESEs per hour <14), and intense (≥14 NESEs per hour). December 2013 and December 2014 were associated with low and medium activity regimes only, while January 2015 had mainly medium and intense activity. The frequency of large eruptions and of NESEs do not show a correlation, supporting the hypothesis of the existence of multiple deep processes at the origin of the gas release. Space analysis of NESEs shows that they emerge over the surface primarily above the conduit, but not isotropically, pointing to complex interaction with the magma lake convection.
Understanding the Physical Forcings Behind the Biogeochemical Productivity of the Hudson Bay Complex
Authors: Deschepper Inge , Myers Paul G. , Lavoie Diane , Papakyriakou Tim , Maps Fréderic
Published: June 2023

Multiple factors influence the spatial and temporal chlorophyll‐a concentration of marine systems. The Hudson Bay Complex has historically been seen as a large, low‐production inland sea situated in the north of Canada. However, recent field campaigns, for the BaySys project, have provided new data on primary production in the bay. Due to the Hudson Bay complex's positioning, it experiences seasonal sea‐ice cover and has many rivers draining into it, resulting in a unique estuarine‐like environment. We use the biogeochemical model BLINGv0 + DIC, coupled to the online regional physical oceanographic and sea‐ice models, NEMOv3.6 and LIM2, respectively, forced with two bias‐corrected Coupled Model Intercomparison Project 5 climate forcings (MIROC5 and MRI) to simulate the base of the ecosystem. The simulations were evaluated with chlorophyll‐a satellite imagery and observations collected in 2018 and analyzed with Empirical Orthogonal Functions to understand the underlying physical forcings and key areas of chlorophyll‐a concentration distribution. The evaluation showed that both simulations successfully reproduced the sea‐ice melt, from west to east and formation, from north to south and correlated well with spatial bloom patterns. The main drivers of phytoplankton growth are the seasonal light and nutrient levels (48% and 54%), the mixed layer depth dynamics (18% and 14%), nutrient supply from rivers (13% and 8%), and sea ice production (7%) for the MIROC5 and MRI simulations, respectively. The sea‐ice dynamics and river runoff played a significant role in the system's productivity. Therefore, with future climate change and increased river regulation projects, up to 20% of overall chlorophyll‐a may be negatively impacted.
Asymmetric Impacts of El Niño Development and Decay Stages on the Hadley Circulation
Authors: Feng Juan , Ji Xuanliang , Li Jianping , He Enye
Published: June 2023

The impact of El Niño on the Hadley Circulation (HC) has been a topic of previous studies, but the results have been inconclusive. We study how El Niño affects the HC during different stages of its cycle. In development years, the HC anomaly shows an equatorial quasi‐symmetric pattern, while in decay years, it shows an asymmetric pattern. This resolves previous discrepancies among studies about El Niño's impacts on the HC. The differences in tropical sea surface temperature (SST) during different stages of El Niño cause differences in SST meridional gradients, which determine the location of convergence. This explains why the HC anomalies have different spatial structures during El Niño development and decay years. Our results show that the meridional distribution of SST during different El Niño stages has significantly distinct impacts on meridional circulation and clarify the differences in El Niño's effects on climate.
Fluxbots: A Method for Building, Deploying, Collecting and Analyzing Data From an Array of Inexpensive, Autonomous Soil Carbon Flux Chambers
Authors: Forbes Elizabeth , Benenati Vincent , Frey Spencer , Hirsch Mare , Koech George , Lewin Grace , Mantas John Naisikie , Caylor Kelly
Published: June 2023

Soil carbon flux rates are a crucial metric of carbon cycling that contribute to calculating an ecosystem's carbon budget, and thus whether it is a source or sink of atmospheric carbon dioxide. However, soil carbon flux datasets are frequently low‐resolution across either space or time, limiting our abilities to identify small‐scale ecological contexts that influence soil carbon dynamics. Existing datasets are distributed unevenly, with some soil carbon‐rich regions (like tropical grasslands) significantly understudied. We developed an autonomous, inexpensive, do‐it‐yourself (DIY) soil carbon flux chamber (a “fluxbot”) and data processing software. We deployed a distributed array of 12 fluxbots in a long‐term experiment in a central Kenyan savanna where it has been logistically impossible to collect high‐resolution soil carbon flux data. With this array we collected over 10,000 individual flux estimates over almost two months, spanning the end of a dry season and the start of a wet season. With our successful deployment in situ, we demonstrate the potential for low‐cost, autonomous, DIY sensors in improving resolution of soil carbon flux datasets (particularly in under‐studied or logistically challenging systems). If implemented widely, such an improvement in data collection capacities could improve our understanding of ecological and climatic drivers of soil carbon flux dynamics on the local to global scale.
Exploring Spatiotemporal Paleoenvironmental and Paleoceanographic Changes on the Continental Shelf Using Authigenic Greigite: A Case Study From the East China Sea
Authors: Liu Jianxing , Xu Taoyu , Zhang Qiang , Yu Xiaoxiao , Wu Yonghua , Liu Qingsong , Shi Xuefa
Published: June 2023

The lack of suitable indicators of changes in such as sea‐level and circulation has been a major limit to paleoenvironmental and paleoceanographic investigations in continental shelf regions. This paper presents an environmental magnetic study by comparing two late‐Quaternary sediment cores (DH02 and DH03) from the outer shelf of the East China Sea (ECS). Late and early Marine Isotope Stage (MIS) 3 sediments were deposited in a prodelta under cold coastal currents and an open‐shelf with the Taiwan Warm Current and upwelling. The dominant iron‐bearing minerals of the late and early MIS 3 sediments are authigenic greigite (Fe3S4) and pyrite (FeS2), respectively, which were assumed to be formed nearly syndepositionally. The overlying sediments, however, are magnetically dominated by detrital magnetite. This pattern corresponds well to the temporal changes in sea‐level over this period. The widespread occurrence of greigite in the late MIS 3 sediments can also be used for future stratigraphic division and correlation in the ECS. Additionally, compared to microfossil assemblages, rock magnetic parameters based on greigite may be more sensitive to environmental changes on continental shelves. Furthermore, the inter‐borehole spatial comparisons imply not only a sedimentary hiatus/erosion of at least 30‐m thickness in core DH02, most probably during the Last Glacial Maximum, but also that core DH02 was in a more reductive environment than core DH03 during late MIS 3. The findings highlight the potential of authigenic greigite as an indicator of spatiotemporal changes in paleoenvironmental and paleoceanographic conditions on the continental shelf at orbital or even suborbital timescales.
A Physics‐Aware Machine Learning‐Based Framework for Minimizing Prediction Uncertainty of Hydrological Models
Authors: Roy Abhinanda , Kasiviswanathan K. S. , Patidar Sandhya , Adeloye Adebayo J. , Soundharajan Bankaru‐Swamy , Ojha Chandra Shekhar P.
Published: June 2023

Modeling hydrological processes for managing the available water resources effectively is often complex due to the existence of high nonlinearity, and the associated prediction uncertainty mainly arising from model inputs, parameters, and structure. Despite several attempts to quantify the model prediction uncertainty, reducing the same for improving the reliability of models is indispensable for their wider acceptance. This paper presents a novel modeling framework for minimizing the prediction uncertainty in the streamflow simulation of the conceptual hydrological model (HBV) by integrating with the Bayesian‐based Particle Filter technique (PF) and machine learning algorithm (Random Forest algorithm, RF). Initially, the streamflow prediction interval (PI) is derived from the stochastically estimated parameters of the HBV model through the PF technique (HBV‐PF model). As the HBV‐PF model quantifies only parametric uncertainty, the RF algorithm was employed (HBV‐PF‐RF model) for further minimizing the prediction uncertainty by inherently taking care of different sources of uncertainty. The RF algorithm inherently combines the physics of the hydrological system (i.e., process‐based variables) with machine learning‐based approach to minimize the overall prediction uncertainty. The proposed framework was analyzed on Nepal and India's Sunkoshi and Beas River basins, through several statistical performance indices for assessing the accuracy and uncertainty of the model prediction. The framework was observed to be consistently improving the model performance minimizing the uncertainty in both watersheds. Therefore, the proposed framework can be considered to be more reliable in improving the prediction capability of hydrological models.
Initial severity of the Positive and Negative Syndrome Scale (PANSS)-30, its main subscales plus the PANSS-6, and the relationship to subsequent improvement and trial dropout: a pooled participant-level analysis of 18 placebo-controlled risperidone and paliperidone trials
Authors: Hieronymus Fredrik , Correll Christoph Ulrich , Østergaard Søren Dinesen
Published: June 2023

Greater initial severity on the 30-item Positive and Negative Syndrome Scale (PANSS-30) correlates positively with antipsychotic-placebo separation and trial dropout, but it is unknown whether these associations are present also on PANSS-derived subscales. We assessed the relationship between initial severity and antipsychotic-placebo separation as measured by PANSS-30 and four PANSS symptom subscales: the positive (PANSS-POS), negative (PANSS-NEG), general (PANSS-GEN) and 6-item (PANSS-6) subscales, using patient-level data from 18 placebo-controlled risperidone and paliperidone trials. Analysis of covariance in the intention-to-treat population (last-observation-carried-forward) was used to assess antipsychotic-placebo separation and trial dropout. Across 6685 participants (90% schizophrenia, 10% schizoaffective disorder), the initial severity-by-treatment interaction was statistically significant for PANSS-30 (beta: −0.155; p < 0.001) and all PANSS subscales (beta range: −0.097 to −0.135; p-value range: < 0.001 to 0.002). In all cases, antipsychotic-placebo differences increased with initial severity. Judging by the distribution of relative outcomes (percent remaining symptoms), the interaction was partly explained by an increased chance of responding, but also by larger numerical responses in those who did respond, as initial severity increased. Except for PANSS-NEG, high initial severity on all PANSS scales predicted increased trial dropout, although not statistically significantly so for PANSS-6. In summary, we thus replicate previous findings showing greater initial severity to predict larger antipsychotic-placebo separation and extend these results to four PANSS subscales. For PANSS-POS and PANSS-GEN, but not for PANSS-NEG and PANSS-6, we also replicate the association between initial severity and trial dropout. Patients with low initial negative symptom severity were identified as a group of particular interest for further study since their results diverged most from the average both with regard to antipsychotic-placebo separation (low separation measured by PANSS-NEG) and trial dropout (high level).
The ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma
Authors: Wang Kun , Chen Siyu , Wu Yue , Wang Yang , Lu Yousheng , Sun Yanzi , Chen Yijun
Published: June 2023

Pancreatic adenocarcinoma (PAAD) is the most malignant cancer with a high mortality rate. Despite the association of ribosomal protein L10 (RPL10) with PAAD and previous reports on RPL26 ufmylation, the relationship between RPL10 ufmylation and PAAD development remains unexplored. Here, we report the dissection of ufmylating process of RPL10 and potential roles of RPL10 ufmylation in PAAD development. The ufmylation of RPL10 was confirmed in both pancreatic patient tissues and cell lines, and specific modification sites were identified and verified. Phenotypically, RPL10 ufmylation significantly increased cell proliferation and stemness, which is principally resulted from higher expression of transcription factor KLF4. Moreover, the mutagenesis of ufmylation sites in RPL10 further demonstrated the connection of RPL10 ufmylation with cell proliferation and stemness. Collectively, this study reveals that PRL10 ufmylation plays an important role to enhance the stemness of pancreatic cancer cells for PAAD development.
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
Authors: Iglesias Maria Jesus , Sanchez-Rivera Laura , Ibrahim-Kosta Manal , Naudin Clément , Munsch Gaëlle , Goumidi Louisa , Farm Maria , Smith Philip M. , Thibord Florian , Kral-Pointner Julia Barbara , Hong Mun-Gwan , Suchon Pierre , Germain Marine , Schrottmaier Waltraud , Dusart Philip , Boland Anne , Kotol David , Edfors Fredrik , Koprulu Mine , Pietzner Maik , Langenberg Claudia , Damrauer Scott M. , Johnson Andrew D. , Klarin Derek M. , Smith Nicholas L. , Smadja David M. , Holmström Margareta , Magnusson Maria , Silveira Angela , Uhlén Mathias , Renné Thomas , Martinez-Perez Angel , Emmerich Joseph , Deleuze Jean-Francois , Antovic Jovan , Soria Fernandez Jose Manuel , Assinger Alice , Schwenk Jochen M. , Souto Andres Joan Carles , Morange Pierre-Emmanuel , Butler Lynn Marie , Trégouët David-Alexandre , Odeberg Jacob
Published: June 2023

Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. Here we show, using proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, how Complement Factor H Related 5 protein (CFHR5), a regulator of the alternative pathway of complement activation, is a VTE-associated plasma biomarker. In plasma, higher CFHR5 levels are associated with increased thrombin generation potential and recombinant CFHR5 enhanced platelet activation in vitro. GWAS analysis of ~52,000 participants identifies six loci associated with CFHR5 plasma levels, but Mendelian randomization do not demonstrate causality between CFHR5 and VTE. Our results indicate an important role for the regulation of the alternative pathway of complement activation in VTE and that CFHR5 represents a potential diagnostic and/or risk predictive plasma biomarker.
All-silicon quantum light source by embedding an atomic emissive center in a nanophotonic cavity
Authors: Redjem W. , Zhiyenbayev Y. , Qarony W. , Ivanov V. , Papapanos C. , Liu W. , Jhuria K. , Al Balushi Z. Y. , Dhuey S. , Schwartzberg A. , Tan L. Z. , Schenkel T. , Kanté B.
Published: June 2023

Silicon is the most scalable optoelectronic material but has suffered from its inability to generate directly and efficiently classical or quantum light on-chip. Scaling and integration are the most fundamental challenges facing quantum science and technology. We report an all-silicon quantum light source based on a single atomic emissive center embedded in a silicon-based nanophotonic cavity. We observe a more than 30-fold enhancement of luminescence, a near-unity atom-cavity coupling efficiency, and an 8-fold acceleration of the emission from the all-silicon quantum emissive center. Our work opens immediate avenues for large-scale integrated cavity quantum electrodynamics and quantum light-matter interfaces with applications in quantum communication and networking, sensing, imaging, and computing.
Spatial distribution of three ARGONAUTEs regulates the anther phasiRNA pathway
Authors: Tamotsu Hinako , Koizumi Koji , Briones Alejandro Villar , Komiya Reina
Published: June 2023

Argonaute protein (AGO) in association with small RNAs is the core machinery of RNA silencing, an essential mechanism for precise development and defense against pathogens in many organisms. Here, we identified two AGOs in rice anthers, AGO1b and AGO1d, that interact with phased small interfering RNAs (phasiRNAs) derived from numerous long non-coding RNAs. Moreover, 3D-immunoimaging and mutant analysis indicated that rice AGO1b and AGO1d cell type-specifically regulate anther development by acting as mobile carriers of these phasiRNAs from the somatic cell layers to the germ cells in anthers. Our study also highlights a new mode of reproductive RNA silencing via the specific nuclear and cytoplasmic localization of three AGOs, AGO1b, AGO1d, and MEL1, in rice pollen mother cells.
Resistance to thyroid hormone induced tachycardia in RTHα syndrome
Authors: Dore Riccardo , Watson Laura , Hollidge Stefanie , Krause Christin , Sentis Sarah Christine , Oelkrug Rebecca , Geißler Cathleen , Johann Kornelia , Pedaran Mehdi , Lyons Greta , Lopez-Alcantara Nuria , Resch Julia , Sayk Friedhelm , Iwen Karl Alexander , Franke Andre , Boysen Teide Jens , Dalley Jeffrey W. , Lorenz Kristina , Moran Carla , Rennie Kirsten L. , Arner Anders , Kirchner Henriette , Chatterjee Krishna , Mittag Jens
Published: June 2023

Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart. Surprisingly, we report that treatment of RTHα patients with thyroxine to overcome tissue hormone resistance does not elevate their heart rate. Cardiac telemetry in male, TRα1 mutant, mice indicates that such persistent bradycardia is caused by an intrinsic cardiac defect and not due to altered autonomic control. Transcriptomic analyses show preserved, thyroid hormone (T3)-dependent upregulation of pacemaker channels (Hcn2, Hcn4), but irreversibly reduced expression of several ion channel genes controlling heart rate. Exposure of TRα1 mutant male mice to higher maternal T3 concentrations in utero, restores altered expression and DNA methylation of ion channels, including Ryr2. Our findings indicate that target genes other than Hcn2 and Hcn4 mediate T3-induced tachycardia and suggest that treatment of RTHα patients with thyroxine in high dosage without concomitant tachycardia, is possible.
Role of the Maritime Continent in the remote influence of Atlantic Niño on the Pacific
Authors: Liu Siying , Chang Ping , Wan Xiuquan , Yeager Stephen G. , Richter Ingo
Published: June 2023

Atlantic Niño, the dominant climate mode in the equatorial Atlantic, is known to remotely force a La Niña-like response in the Pacific, potentially affecting seasonal climate predictions. Here, we use both observations and large-ensemble simulations to explore the physical mechanisms linking the Atlantic to the Pacific. Results indicate that an eastward propagating atmospheric Kelvin wave from the Atlantic, through the Indian Ocean, to the Pacific is the primary pathway. Interaction of this Kelvin wave with the orography of the Maritime Continent induces orographic moisture convergence, contributing to the generation of a local Walker Cell over the Maritime Continent-Western Pacific area. Moreover, land friction over the Maritime Continent dissipates Kelvin wave energy, affecting the strength of the Bjerknes feedback and thus the development of the La Niña-like response. Therefore, improving the representation of land–atmosphere–ocean interactions over the Maritime Continent may be fundamental to realistically simulate Atlantic Niño’s impact on El Niño-Southern Oscillation.
Eye tracking and eye expression decoding based on transparent, flexible and ultra-persistent electrostatic interface
Authors: Shi Yuxiang , Yang Peng , Lei Rui , Liu Zhaoqi , Dong Xuanyi , Tao Xinglin , Chu Xiangcheng , Wang Zhong Lin , Chen Xiangyu
Published: June 2023

Eye tracking provides valuable insight for analyzing visual attention and underlying thinking progress through the observation of eye movements. Here, a transparent, flexible and ultra-persistent electrostatic sensing interface is proposed for realizing active eye tracking (AET) system based on the electrostatic induction effect. Through a triple-layer structure combined with a dielectric bilayer and a rough-surface Ag nanowire (Ag NW) electrode layer, the inherent capacitance and interfacial trapping density of the electrostatic interface has been strongly enhanced, contributing to an unprecedented charge storage capability. The electrostatic charge density of the interface reached 1671.10 μC·m−2with a charge-keeping rate of 96.91% after 1000 non-contact operation cycles, which can finally realize oculogyric detection with an angular resolution of 5°. Thus, the AET system enables real-time decoding eye movements for customer preference recording and eye-controlled human-computer interaction, supporting its limitless potentiality in commercial purpose, virtual reality, human computer interactions and medical monitoring.