bluuebunny/crossref_metadata_2025 huggingface dataset:
MicroRNA and endocrine ophthalmopathy, involvement in glucocorticoid response
Authors:   Department of ophthalmology Russian Medical Academy of Continuous Professional Education, Moscow, Brovkina A.F. ,   Botkin Hospital, Moscow, Sychev D.A. ,   Department of ophthalmology Russian Medical Academy of Continuous Professional Education, Moscow, Toropova O.S. ,   Botkin Hospital, Moscow
Published: June 2021

The accumulated clinical experience proves the existence of glucocorticoid-resistant forms of endocrine ophthalmopathy. It is assumed that epigenetic factors (miRNA) affect the pathogenesis of the disease and are involved in the formation of the glucocorticoid response. Purpose. To study the role of miRNA-146a and miRNA-155 in patients with clinical forms of endocrine ophthalmopathy and to assess their effect on the glucocorticoid response. Material and method: The study included 20 patients (40 orbits) with image intensifier tubes, treated with glucocorticoids (GC) with a negative result, mean age – 52.65 ± 12.6 years. The control group - 28 volunteers without autoimmune and tumor diseases, age 62.9 ± 7.54 years. The expression level of miRNA-155 and miRNA-146a was determined by real-time PCR. Results: The obtained data indicate an increase in the expression level of miRNA-146a and miRNA-155 in patients with clinical forms of endocrine ophthalmopathy at the stage of fibrosis (p <0.01). Conclusion: The obtained results of the functional activity of miRNA-146a and miRNA-155 confirm their participation in the pathogenesis of the development of edematous exophthalmos and endocrine myopathy by activating the fibroplastic process. Key words: endocrine ophthalmopathy, GC therapy, microRNA.
The influence of para-aminobenzoic acid on the inflammatory process in dry eye disease in patients with diabetes mellitus (clinical and laboratory research)
Authors:   Moscow Regional Research and Clinical Institute (MONIKI) n.o. M.F. Vladimirsky, Moscow, Ryabtseva A.A. , Ali-Zade G.K. ,   Moscow Regional Research and Clinical Institute (MONIKI) n.o. M.F. Vladimirsky, Moscow, Akberova S.I. ,   Medical center «Medkvadrat», Moscow, Moskalets O.V. ,   Moscow Regional Research and Clinical Institute (MONIKI) n.o. M.F. Vladimirsky, Moscow, Andryukhina A.S. ,   Moscow Regional Research and Clinical Institute (MONIKI) n.o. M.F. Vladimirsky, Moscow
Published: June 2021

Purpose. Study of the effect of 0.007% PABA solution in the form of the drug Aktipol-M on the inflammatory process based on the assessment of the level of sIL-6R and NE in the lacrimal fluid (LF), with dry eye disease (DED) in patients with diabetes mellitus (DM). Material and methods. The study involved 30 patients (60 eyes) with type 1 and 2 diabetes, aged 35 to 70 years, with a diagnosis of DED. Patients received Aktipol-M eye drops for one month. The contents of NE (10 patients, 20 eyes) and sIL-6R (20 patients, 40 eyes) were determined in the LF. The control group consisted of 10 healthy volunteers (20 eyes). Quantitative determination of the content of sIL-6R and NE was carried out by the method of enzyme-linked immunosorbent assay. Thirty patients (60 eyes) with type 1 and 2 diabetes, aged 35 to 70 years, with a diagnosis of DED were examined. The patients received Aktipol-M eye drops for one month. The content of NE (10 patients, 20 eyes) and sIL-6R (20 patients, 40 eyes) was determined in the LF. The control group consisted of 10 healthy volunteers (20 eyes). The quantitative determination of the content of sIL-6R and NE was carried out by the method of enzyme-linked immunosorbent assay. Results. The patients showed a higher content of sIL-6R (10974.8±1228.5 pkg/ml) and NE (3.85 ± 0.13 ng / ml) compared with the control group (4.6 ± 0.7 pkg / ml and 0.22 ± 0.08 ng/ml, respectively). After 1 month after the start of treatment, a significant decrease in these parameters was observed in all patients and in both eyes: on average, the content of sIL-6R by 80.5% and the NE content by 58.7%. Conclusion. PABA 0.007% in the dosage form of eye drops Aktipol-M has an anti-inflammatory effect, suppressing the production of sIL-6R and NE in the LF in DED in patients with diabetes. Key words: para-aminobenzoic acid, dry eye disease, diabetes mellitus, inflammation, neutrophilic elastase, soluble interleukin-6 receptor.
Еffects of optical correction methods on accomodation in children with progressive myopia (literature review)
Authors:   National Myopia Institute, Moscow, Poskrebysheva Z.N. , Tyurina A.A. ,   National Myopia Institute, Moscow, Zhabina O.A. ,   National Myopia Institute, Moscow, Avetisov S.E. ,   Research Institute of Eye Diseases, Moscow, Myagkov A.V. ,   National Myopia Institute, Moscow
Published: June 2021

Accommodation disorders in young people are more common than diagnosed. This review is based on the data of domestic and foreign literature and studies the effect of contact lenses of various designs on accommodation. Particular attention has been given to bifocal soft contact lenses as one of the recognized interventions for treating juvenile progressive myopia and their ability to slow axial elongation. Key words: accommodation, myopia control, bifocal contact lenses, orthokeratology.
Local antibiotic therapy of bacterial infectious and inflammatory diseases of the anterior segment of the eye (literature review)
Authors:   Ufa Eye Research Institute, Ufa, Babushkin A.E.
Published: June 2021

Inflammatory eye diseases are one of the most important problems of ophthalmology. They can be caused by various pathogens of the infection, which is still more often bacterial. Therapy of bacterial inflammatory diseases of the eye involves the use of antibacterial drugs (sulfonamides, antiseptics, nitrofurans, etc.), among which antibiotics are of primary importance. Of this group of drugs, in this review article, special attention is paid to quinolones, mainly synthetic fluoroquinolones, which are distinguished by a wide range of bactericidal action, fairly high efficiency, low level of resistance of microorganisms to it and the frequency of side effects, as well as good tolerability by patients, i.e. they best meet the requirements for modern topical antimicrobial agents. In certain clinical situations and indications, it is advisable to use ophthalmic antiseptics and combined preparations containing several antibiotics of different effects at once, or an antibiotic and a corticosteroid. Key words: infectious and inflammatory eye diseases, antibacterial agents, antibiotics, combined preparations, antiseptics.
ANALISIS PENGEMBANGAN USAHA NENAS SAKINAH BERDASARKAN ASPEK KEUANGAN KONVENSIONAL DAN SYARIAH (HAMDI’S METHOD)
Authors: Agustin Hamdi , Azmi Novita , Armis  , Asril
Published: June 2021

Penelitian ini dilakukan pada Usaha Keripik Nanas Sakinah yang terletak di Jl. Raya Pekanbaru-Bangkinang, Km. 26,5 Kualu Nenas, Kecamatan Tambang, Kabupaten Kampar, Provinsi Riau. Tujuan penelitian ini adalah menganalisis pengembangan usaha Keripik Nanas Sakinah berdasarkan aspek-aspek keuangan. Analisis aspek keuangan berdasarkan konvensional terdiri dari Net Present Value (NPV), Payback Period (PP), Profitability Index (PI). Aspek keuangan berdasarkan syariah Islam dengan menggunakan Hamdi’s Method terdiri dari Gold Value Method (GVM), Gold Index (GI) dan Investible Surplus Method (ISM). Hasil penelitian ini menunjukkan bahwa usaha Keripik Nanas Sakinah layak untuk dikembangkan berdasarkan hasil analisis aspek keuangan.
Utilidad de la pH-metría en el reflujo gastroesofágico
Authors: Campoverde Chiquito Hilda Margarita , Yagual Lucas Gonzalo Mauricio , Haro Parra Astrid Carolina , Valencia Rodríguez Ronald Adrián
Published: June 2021

El reflujo gastroesofágico (RGE) es el paso del contenido gástrico hacia el esófago con o sin vómitos o regurgitación, esta última se diferencia del vómito porque se realiza sin esfuerzo y no se presenta en forma explosiva, aunque a veces en el lactante menor puede ser muy intensa. El RGE es un fenómeno fisiológico que ocurre en todas las edades, pero principalmente en el lactante, en que la mayoría de los episodios de RGE duran menos de tres minutos, ocurren en período post prandial y cursan con pocos o ningún síntoma. Existe el criterio generalizado entre los médicos, incluidos los gastroenterólogos, que el diagnóstico del reflujo gastroesofágico (RGE) patológico puede formularse en la mayoría de los casos en base al cuadro clínico, particularmente por la presencia de los síntomas clásicos de pirosis y regurgitación. Sin embargo. Aun cuando el «gold standard» para el diagnóstico de reflujo ácido patológico hacia el esófago, es el estudio de pH de 24h. Se considera que los síntomas son molestos y alteran la calidad de vida cuando ocurren dos o más veces por semana. Es una entidad muy prevalente en la población general. En Japón afecta del 6,5 al 9,5% de la población, en EE.UU. 10% a 20%, Europa cercano a 10% y 20% y en América Latina del 11,9 al 31,3%. Se estima que su incidencia es del 4,5-5,4/1000 pacientes por año. La metodología de la investigación, es una revisión de tipo bibliográfico, que se ha apoyado en medios electrónicos como Google Académico, PubMed, entre otros, para la obtención de la información. La hpmetria es una de más mejores técnicas para el manejo de pacientes con RGE, que, junto con el tratamiento médico, han logrado la disminución del tratamiento quirico. La utilidad de la hpmetria está más que demostrada, ya que: permite evaluar la cantidad de relajaciones transitorias que ocurren en el esfínter esofágico inferior, es útil para evaluar la respuesta a la terapia anti secretora, permite determinar la asociación temporal entre el reflujo ácido y frecuencia de un síntoma como tos y en los asmáticos o sibilantes, detectar reflujo ácido que puede ser un factor agravante de sus crisis, se utiliza fundamentalmente para confirmar la sospecha de RGE en pacientes que no responden al tratamiento empírico y presentan endoscopia normal, entre otras.
Stress-strain analysis of details and units of the seeding section of a grain seed drill
Authors: Ovtov Vladimir Alexandrovich , Yashin Alexandr Vladimirovich , Khaleev Dmitriy Yurevich
Published: June 2021

The analysis of failure of parts and units of the sowing section during abnormal operation of seeders is given. Using modern CAD systems, a stress-strain analysis of parts and assemblies of the sowing section was carried out, which made it possible to identify a failure above the indicated one, which is associated with a violation of the technological and technical process of operating seeders when sowing grain and industrial crops.
Influence of Waste Tire Rubber Particles Size on the Microstructural, Mechanical, and Acoustic Insulation Properties of 3D-Printable Cement Mortars
Authors: Sambucci Matteo , Valente Marco
Published: June 2021

3D printing technologies of construction materials are gaining ground in the building industry. As well documented in the literature, these advanced manufacturing methodologies aim to reduce work-related injuries and materials waste, enhancing architectural flexibility which would enable more sophisticated designs for engineering and aesthetic purposes. In this framework, the development of functional and eco-sustainable printable materials represents an extremely attractive challenge for research, promoting digital fabrication to reach its maximum cost-effective and technological potentials. The use of recycled tire rubber particles in 3D printable Portland-based compounds is an exclusive contribution in this field. This line of research aims to integrate the well-known engineering performances of rubber-cement materials with the advanced peculiarities of additive manufacturing methodologies. As an innovative contribution, the authors propose here a detailed study on the possible relationship between rubber particle size and technological properties of the 3D printable mix. Specifically, two groups of continuous size grading polymer aggregates (0-1 mm rubber powder and 1-3 mm rubber granules as fine and coarse fractions, respectively) were analyzed in terms of impact on rheology, print quality, microstructure, mechanical properties, and acoustic insulation performance. Concerning the print quality, rubber aggregates altered the fluidity of the fresh mix, improving the adhesion between the printed layers and therefore enhancing the mechanical isotropy in the post-hardening sample. A remarkable influence of the rubber gradation on the compounds’ behaviour was found in hardened properties. By comparing the rubberized compounds, the fine polymer fraction shows greater interfacial cohesion with the cement paste. However, more significant mechanical strength loss was found due to a greater reduction in density and increased porosity degree. On the other hand, mortars doped with larger rubber particles tend to have a higher unit weight, finest pore distribution, minor mechanical strength drop, and higher ductility but worse interface binding with the matrix. Regarding the acoustic insulation properties, a proper balance between rubber powder and granules in the mixes allows to obtain comparable/superior performance compared to plain mortar but the effect of the aggregate size is strongly dependent on the sound frequency range investigated. Future findings revolve around applicability studies of these formulations in civil and architectural fields, benefiting from the design flexibility of 3D printing. Doi: 10.28991/cej-2021-03091701 Full Text: PDF
Assessment and Evaluation of Blended Cement Using Bamboo Leaf Ash BLASH Against Corrosion
Authors: Dacuan Cecielle N. , Abellana Virgilio Y. , Canseco Hana Astrid R.
Published: June 2021

Concrete provides a high degree of protection against corrosion of embedded steel reinforcement. Owing to the harsh environmental conditions and the presence of aggressive elements from the marine environment, deteriorating corrosion affects the durability of reinforced concrete structures. This study evaluated the effectiveness of bamboo leaf ash BLASH as a supplementary cementing material or admixture with Portland cement to improve the durability of reinforced concrete structures. Specimens of 0, 10, 15, and 20% BLASH mixtures were prepared using 16, 20, and 25 mm  steel reinforcements. A total of 100 cylindrical specimens were cast and used in this study. The specimens were accelerated by corrosion using impressed current techniques and a galvanostatic method in a simulated environment. The results show that specimens with a BLASH content of 10% exhibited superior performance and exhibited longer corrosion initiation and propagation times. It has a higher resistance to acid penetration and lower corrosion rates. The crack parameters of the specimen with BLASH admixtures, such as the crack width and crack frequency, were negligible. The use of BLASH as an admixture strengthens its durability and improves its residual strength and serviceability. Doi: 10.28991/cej-2021-03091707 Full Text: PDF
ANALYSIS OF CHARACTERISTIC DAMAGES OF BEARING AND FENCING STRUCTURES IDENTIFIED DURING INSPECTION OF SCHOOL BUILDINGS IN THE ROSTOV REGION
Authors: Buzalo Nina , Klimenko Maksim , Ponomarev Roman
Published: June 2021

The article considers and analyzes the parameters of physical wear and tear of building structures of school buildings, built over the past 50-70 years. The main content of the research is the analysis of materials from surveys of municipal institutions of secondary education in the Rostov region. The paper describes the most common structural schemes of buildings and features of supporting structures. The characteristic deformations and damages of the bearing and enclosing building structures of school buildings are considered and methods for their elimination are proposed. The significant social role of the safety of school buildings and their technical condition for the secondary education system and, as a consequence, the stability of society is noted.
EFECTOS DE LA GRAN RECESIÓN SOBRE LA DISTRIBUCIÓN DEL INGRESO EN MÉXICO
Authors: Ruiz Hernandez Maria del Rosario , Gatica Leonardo Adalberto
Published: June 2021

En este artículo analizamos el impacto que la Gran Recesión tuvo sobre la desigualdad del ingreso en México. Estudiamos tres diferentes dimensiones del ingreso de los hogares: el ingreso por trabajo asalariado, el ingreso total por trabajo y el ingreso monetario. Encontramos que el impacto negativo de la contracción económica sobre la inequidad del ingreso monetario no se observa para el ingreso por trabajo asalariado. Esta diferencia se explica por la caída en el ingreso por negocios que afectó en mayor proporción a los hogares del decil más alto, que a los hogares en los cuatro deciles más bajos de la distribución. Esta caída desproporcionada, de los ingresos por negocios, redujo ligeramente la desigualdad de los ingresos totales del trabajo. En el nivel regional se observan efectos heterogéneos; algunos de ellos se contraponen a lo observado en promedio, en el nivel nacional.
DESIGN OF DC CHOPPER CONTROL CIRCUIT
Authors: Alobaidly Ali
Published: June 2021

The aim of this research is to design a control power circuit which has the ability to operate the solenoid valve, the pump and the DC motor of the bottle filling machine. This circuit contains of three main parts the PIC16F876a, the Interface Circuit and the Snabber Circuit. The power circuit is supplied by 110 V. The (PIC 16F876a) is supplied by 5 V. The power switch MOSFET is supplied by 24 V. The Snabber Circuit and the interface circuit are designed in this research. The purpose and the role of the circuit and the Interface Circuit in the power control circuit are determined in this research.
Educar en la p´ractica de la Economía Social y Solidaria
Authors: Astudillo José
Published: June 2021

La Economía Social y Solidaria es una alternativa para superar la múltiple y compleja crisis que vive la humanidad en su relación con la naturaleza.  Es imperativo dar un salto cualitativo del discurso a la praxis, que conlleve a una coherencia entre lo que se habla, escribe y se practica; por lo que un proceso de educación en Economía Social Popular y Solidaria tiene necesariamente que recuperar la historia de la cooperación y la organización, a través de nuevas propuestas educativas y proyectarlas a la construcción de escenarios concretos y creíbles que se plasmen en Buenos Vivires.
Peningkatan Keandalan Load Lugger dengan Pendekatan Failure Mode and Effect Analysis
Authors: Fitriah Fitriah , Setiawan Heri , Nalhadi Ahmad , Sucipto Eko Hadi , Supriyadi Supriyadi
Published: June 2021

Masalah: Keandalan peralatan merupakan salah faktor untuk meningkatkan produktivitas kerja.  Tingkat downtime yang tinggi pada mesin load lugger membuat delay pekerjaan yang berdampak pada kinerja peralatan

Tujuan: mengetahui tingkat availability load lugger dan perbaikan terhadap tingkat downtime untuk meningkatkan availability load lugger.

Metodologi: penelitian ini menggunakan metode Failure Mode and Effect Analysis (FMEA) untuk mengetahui proses yang menyebabkan downtime terbesar.

Temuan/Hasil Penelitian: Perbaikan dengan cara memodifikasi desain pin hook serta mengganti material pin hook agar lebih kuat menahan beban scrap box dan meningkatkan lifetime pin hook dapat meningkatkan nilai availability dari 74% menjadi 99%. Implementasi FMEA efektif dalam mengidentifikasi tingkat kerusakan suatu peralatan sebagai dasar melakukan perbaikan.

Jenis penelitian: Riset lapangan
Pengaruh Display, Promosi Penjualan dan Kualitas Produk Pada Toko Online Terhadap Loyalitas Konsumen Dengan Variabel Intervening Kepuasan Pelanggan
Authors: Indah Lestari Novia
Published: June 2021

Perkembangan teknologi mendorong perilaku belanja konsumen pada sikap belanja online. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh display, promosi penjualan, dan kualitas produk yang dijual secara online terhadap loyalitas konsumen dengan menambahkan variabel intervening kepuasan pelanggan untuk melihat pengaruhnya. 116 responden di Kota Bandung yang pernah melakukan pembelian produk secara online dilibatkan. Hasil penelitian menunjukkan display toko online secara parsial tidak berpengaruh dan signifikan terhadap loyalitas konsumen, sedangkan promosi penjualan dan kualitas produk berpengaruh dan signifikan terhadap loyalitas konsumen. Secara Simultan display dan promosi penjualan tidak signifikan terhadap loyalitas konsumen dan berdasarkan hasil perhitungan promosi penjualan dan kualitas produk berpengaruh terhadap loyalitas konsumen. Hasil perhitungan setelah ditambahkan intervening, kepuasan pelanggan dengan sobel test, berpengaruh mediasi karena konsumen yang puas dengan kualitas produk mampu meningkatkan loyalitas konsumen. Display dan promosi penjualan, setelah dimasukkan variabel intervening tidak mampu meningkatkan loyalitas konsumen karena kepuasan pelanggan atas display toko online dan promosi rendah.

Kata Kunci : Toko online,display, promosi penjualan, kualitas produk, kepuasan pelanggan, loyalitas konsumen.
E-Purchasing Trends for the Time of Covid-19 Pandemic
Authors: P Nivetha
Published: June 2021

The Corona virus has dramatically changed the world. These variations are unintended effects of already existing files. It explores how e-commerce is entering the market and its effect on consumers’ shopping habits and purchasing power. This article addresses e-retailers’ supremacy in the retail sector because of online shopping. Due to Corona virus effect of Computers, e-Purchasing would increase greatly. We want to assess the possible importance of this in monetary and government policymaking.
AN INSTITUTIONAL REINFORCEMENT MODEL FOR THE PROTECTION OF MANGROVES SUSTAINABLE ECOTOURISM IN INDONESIA
Authors:   Universitas Brawijaya, Faculty of Fisheries and Marine Science, Indonesia, PURWANTI Pudji , FATTAH Mochammad ,   Universitas Brawijaya, Faculty of Fisheries and Marine Science, Indonesia, QURRATA Vika Annisa ,   Universitas Negeri Malang, Faculty of Economics, Indonesia, NARMADITYA Bagus Shandy ,   Universitas Negeri Malang, Faculty of Economics, Indonesia
Published: June 2021

This study aims at examining the sustainability of mangrove ecotourism at Cengkrong Mangroves Ecotourism in Indonesia. A quantitative approach was adopted to capture the complexity of the phenomenon. The study was conducted in an area with most mangroves in Indonesia, including Cengkrong Ecotourism in Trenggalek, East Java. Sustainability is achieved when each stakeholder makes a positive contribution to others in ecology, economy, social, institutional and law enforcement, and technology. Using multi-dimensional scaling and Monte Carlo approach, the findings of this study indicate that Cengkrong mangrove ecotourism is classified as “sustainable” (76.20%). The highest dimension is ecology due to the minimum level of pollution in the area. Even Cengkrong beach mangrove is a tourist destination which is potentially polluted by the tourist; however, the area is not densely populated. Nevertheless, amongst the other indicator, social is the lowest (67.95%).
Production technology development baked carbonade
Authors:   Volga Region Research Institute of Manufacture and Processing of Meat-and-Milk Production, Gorlov I.F. , Bozhkova S.E. ,   Volgograd State Technical University, Gnilomedova S.A. ,   Volgograd State Technical University, Surkova S.A. ,   Volga Region Research Institute of Manufacture and Processing of Meat-and-Milk Production
Published: June 2021

Aim. Development of technology and optimization of the recipe for baked carbonade with improved consumer properties. Material and Methods. The production of the studied samples of carbonade was carried out in accordance with the current regulatory and technical documentation (GOST R 55795-2013). Formulation optimization was performed using Excel. Sampling and preparation of samples for laboratory research was carried out according to a unified methodology in accordance with the requirements of GOST R 51447-99 (ISO 3100-1-91). Determination of organoleptic characteristics was carried out according to the requirements of GOST 9959-91; GOST R 53159-2008; GOST R 53161-2008. The mass fraction of fat was determined according to GOST 23042-86; protein – according to GOST 25011-81. Results. In the process of research, a recipe for baked carbonade was developed. It was revealed that with the introduction of apple pectin into the formulation of baked carbonade, the content of miner-al nutrients increases, and the content of vitamins significantly increases. For the production of baked carbonade, the following salting method was chosen: raw material was injected by brine in an amount of 10% by weight. Then the raw material is massaged in a massager with a drum rotation frequency of 16 rpm for 15 minutes. Heat treatment consists in baking. The carbonade is baked at 100-120 oC for 1-2 hours. The carbonade is considered ready when the temperature in its thick-ness reaches 70-72 oC. The finished product is sent for cooling to the chambers until the temperature reaches 8 oC in the thickness of the product. The developed product was distinguished by high organoleptic and stable physicochemical and mi-crobiological indicators, corresponding to the current regulatory and technical documentation for this type of product. The prime cost of baked carbonade is 439.69 rubles / kg, which at the moment, taking into account the costs of the manufacturer and the distribution network, is the average price in the market. Conclusion. A technology has been developed for the production of baked pork carbonade with high consumer properties, which contributes to the expansion of the range of functional meat products. The product is recommended for a wide range of consumers of different age groups.
TEORI EKONOMI (DAVID RICARDO, THOMAS MALTUS DAN J.B SAY)
Authors: Hendra Samsul
Published: June 2021

Ricardo dianggap pakar ilmu ekonomi sebagai ilmu yang kokoh dalam melibatkan ketepatan hitungan matematika. Penalaran yang digunakan serta kemampuan analisis model dengan melibatkan beberapa variabel mampu menghasilkan kesimpulan yang kuat. Pendekatan matematika untuk memecahkan maslah ekonomi kemudian diikuti oleh John Maynard Keynes, Paul Samuelson, Milton Friedman sehingga model ekonometrik menjadi popular. Teori Ricardo yang terkenal adalah tentang teori keunggulan komparatif
RESUME HTN 151 Riski
Authors: Riski
Published: June 2021

Menurut paham komunis,sifat dan tujuannya partai politik bergantung pada situasi apakah partai komunis berkuasa di negara di mana ia berada atau tidak.di negara di mana partai komunis tidak berkuasa,partai-partai politik lain di anggap sebagai mewakili kepentingan kelas tertentu yang tidak dapat bekerja untuk kepetingan umum
Jalan Panjang RUU MHA Memperoleh Pengakuan
Authors: Gultom Pardomuan
Published: June 2021

“Ubi Societas Ibi Ius, di mana ada masyarakat, di situ ada hukum.” Demikian adagium yang pernah diungkapkan Marcus Tullius Cicero, seorang ahli hukum Romawi yang hidup antara106-43 SM. Ungkapan ini bermakna bahwa hukum lahir dan terbentuk akibat dari pola interaksi sesama anggota masyarakat yang mengandung nilai-nilai dan hubungannya terhadap alam dimana ia tinggal serta melangsungkan kehidupan secara turun-temurun hingga pada akhirnya membentuk kebudayaan.
Predicting Invasive Lobular Carcinoma Using Machine Learning
Authors: P. Rucha
Published: June 2021

The critical identification and prediction of the kind of malignant development should generate an interest in illness research, to assist and manage patients. The criticality of classifying illness patients into high or low risk groups necessitates that several examination groups from the biomedical and bioinformatics fields study and study the use of artificial intelligence (AI) technologies.An approach based on strategic regression and multi-classifiers has been presented to predict breast cancer.To develop deep projections in a different environment based on facts on bosom illness. This article examines the many information mining techniques that make use of classification that may be used to Breast Cancer data to provide deeper projections. Apart from that, this inquiry forecasts the best Model-generating elite by evaluating the dataset using several classifiers. Breast malignant growth dataset was gathered from the UCI AI vault and contains 569 instances with 31 attributes. The data gathering process begins with the simple logistic regression methodology, followed by IBK, K-star, Multi-Layer Perceptron (MLP), Random Forest, Decision table, Decision Trees (DT), PART, Multi-Class Classifiers, and REP Tree. Cross approval with a 10-overlap is used, and preparation is carried out to design and test new Models. The outputs are evaluated against a variety of criteria, including accuracy, root mean square error, sensitivity, specificity, F-Measure, ROC Curve Area, and Kappa measurement, as well as the time required to construct the model. The analysis of the results reveals that, of all the classifiers, Simple Logistic Regression produces the deepest predictions and obtains the best model that produces high and precise results, followed by other techniques. IBK: Nearest Neighbor Classifier, K-Star: Example-Based Classifier, and MLP-Neural Organization Different methods have a lower degree of accuracy when examined using the Logistic relapse methodology.
Nurfadrianti-Resume Htn
Authors: Nurfadrianti
Published: June 2021

Warga negara harus memiliki peran dalam memilih pejabat pemerintah yang penting (Hershey(2014:129)). Model pemilihan secara langsung (direct election model) telah terinstitusionalisasikan dalam politik Indonesia sejak 2005 pilkada serentak 9 desember 2015 yang juga menjadi bentuk implementasi dari amanat UU No. 32 Tahun 2004 tentang pemerintahan daerah. Pasal 56 menyatakan, “kepala daerah dan wakil kepala daerah dipilih dalam satu satu pasangan calon yang dilaksanakan secara demokratis berdasarkan asas langsung, umum, bebas, rahasia, jujur, dan adil.
New Polarization Converter for Reflector Antennas
Authors: Chen Xi
Published: June 2021

This article presents the design and characteristics of new wideband polarization transformer based on a square waveguide with diaphragms. Matching and polarization characteristics of the polarization transformer have been simulated and optimized. Frequency dependences of the simulated characteristics are presented. Developed polarization transformer can be applied in modern satellite antennas.
resume HTN 139 putri Rahayu
Authors: Rahayu Putri
Published: June 2021

Mendefinisikanpartaipolitiktidaklahsederhana. Partaipolitikumumnyabersifatnormatifdanjawabanyangdiberikanolehparailmuwanpolitikberbeda-bedadariwaktukewaktu.Tetapi,adaanggapanumummengenaipartaipolitikyangberangkatdarianggapan bahwa dengan membentuk wadah organisasimereka bisamenyatukanorang-orangyangmempunyaipikiranserupasehinggapikirandanorientasimerekabisadikonsolidasikan.
Bullying in Schools and LGBTQ+ Youth Mental Health: Relations with Voting for Trump
Authors: Hobaica Steven , Kwon Paul , Reiter Shari , Aguilar-Bonnette Aaron , Scott Walter , Wessel Andrea , Strand Paul
Published: June 2021

The current study utilized the 2018 Washington State Healthy Youth Survey to explore the relations among school district political attitudes, bullying experiences, and mental health outcomes, particularly for LGBTQ+ students. Although bullying was associated with greater psychological distress (i.e., anxiety, depression, and suicidality) for all students, LGBTQ+ students experienced more bullying and psychological distress. Bullying experiences mediated the relation between LGBTQ+ identity and psychological distress. However, school district voting record moderated the relation between LGBTQ+ identity and bullying, such that LGBTQ+ students in more conservative districts, or districts with more votes for Donald Trump in the 2016 election, experienced more bullying, which was associated with greater psychological distress. Additionally, increased teacher intervention during instances of bullying was related to less bullying for LGBTQ+ students. Finally, in more conservative-leaning districts, LGBTQ+ students reported less teacher intervention, which was associated with more bullying and psychological distress. Given that political conservatism was related to higher rates of bullying and poorer mental health outcomes for LGBTQ+ students, we recommend improving school-based LGBTQ+ bullying policies to prioritize the mental health of LGBTQ+ youth.
Antiklimaks Revisi Pasal "Karet" UU ITE
Authors: Gultom Pardomuan
Published: June 2021

Haatzai Artikelen merupakan perspektif hukum warisan kolonial Belanda yang hingga kini dianggap sebagai ketentuan yang masih dipakai dalam Kitab Undang-Undang Hukum Pidana (KUHP) yang terdapat pada Pasal 134, 136 bis, 137 ayat (1), 154, 155, dan Pasal 156a dengan penekanan adanya penghinaan, kebencian, dan permusuhan kepada pemerintah atau golongan tertentu. Di masa Orde Baru, Pasal 154 dan Pasal 156 ini kedudukannya diperkuat dengan Putusan Mahkamah Agung Nomor 71 K/Kr/1973.
Discursive construction of migrant otherness on Facebook: A distributional semantics approach
Authors: Yantseva Victoria
Published: June 2021

This work aims to study the social construction of migrant categories and immigration discourse on Swedish-speaking Facebook pages in the last decade. It combines the insights from computational linguistics and the distributional semantics approach with those from classical sociological theories to explore a corpus of more than 1M Facebook posts. This allows one to compare the meanings of labels denoting various categories of migrants and identify the interpretative repertoires used by Facebook users to discuss the immigration topic. The study concludes that, despite the expressions of tolerance and support for refugees and immigrants, the Facebook audience is nevertheless active in the objecti?cation and discursive discrimination of those identified as belonging to either of those discursive categories. The study results are then related to the technological design of new media and the overall social and political climate surrounding the Swedish immigration agenda.
Revision of Ireland’s Cost-Effectiveness Threshold: New State-Industry Drug Pricing Deal Should Adequately Reflect Opportunity Costs
Authors: O'Mahony James F
Published: June 2021

Ireland’s cost-effectiveness threshold is currently €45,000 per quality-adjusted life-year (QALY). It has previously been determined by periodic agreements between the State and a pharma industry lobby body. A new deal is now due and it is therefore timely to re-examine Ireland’s threshold, how it is set and transparency around adherence to it. Previous research has noted a series of problems with the threshold, including that it is likely too high relative to the opportunity cost of unmet need in Ireland’s health system. This means reimbursement at the threshold may do net harm to population health. The high threshold may also mean the Irish health system is failing to satisfy existing legislation on healthcare resource allocation. Recent COVID-19 related pressures on healthcare capacity and public spending appear to increase the urgency for an evidence-based revision of threshold to better reflect opportunity costs within the Irish healthcare system. Despite these problems, the prospects for reform of the threshold do not appear strong as the political and institutional incentives may favour the status quo. At the very least, the State should provide greater transparency regarding how the threshold is set and adhered to. In the longer run, there may be good arguments for partially abandoning thresholds in favour of an auction process to achieve the lowest cost per QALY from new drug interventions.
Audit Studies of Housing in the United States: Established, Emerging, and Future Research
Authors: Gaddis S. Michael , DiRago Nicholas V.
Published: June 2021

Since the 1960s, social scientists, fair housing agencies, and the federal government have conducted hundreds of in-person and correspondence housing audits. Researchers use these covert experiments to make strong causal claims about difficult-to-detect behavior, such as racial, gender, and other types of discrimination. These studies have consistently uncovered discrimination in multiple stages and contexts of the housing exchange process. The housing audit literature is broad and robust, and a number of in-depth reviews already exist. In this chapter, we build on those reviews by focusing attention on emerging areas of inquiry and suggest new avenues of research pursuits. We begin by briefly reviewing the long history of housing audits including in-person HUD audits and correspondence audits of home sales and housing rentals. Next, we discuss three emerging areas of housing audit research – housing choice vouchers, short-term rentals, and roommate searches – and highlight important findings, new innovations, and areas of weakness. Finally, we conclude with a discussion about future directions of housing audits including using experiments to test for ways to reduce discrimination, using additional data to examine the mechanisms of housing discrimination, and designing modified audits to explore discrimination in other stages of housing exchange.
Studying the anticancer activity in vitro of doxorubicin-encapsulated pH-sensitive redox nanoparticles
Authors:   Faculty of Biology and Biotechnology, University of Science, Vietnam National University Ho Chi Minh city (VNU-HCMC), Nguyen Thi Hoang , Trinh Nhu Thuy ,   Faculty of Biology and Biotechnology, University of Science, Vietnam National University Ho Chi Minh city (VNU-HCMC), Vong Binh Long ,   School of Biomedical Engineering, International University, VNU-HCMC
Published: June 2021

Doxorubicin (DOX) is known as a chemotherapeutic agent for treating a variety of cancers. However, due to non-specific distribution, DOX causes severe side effects, leading to the limitation of its clinical application. In this study, pH-sensitive redox nanoparticles containing DOX were studied to form drug-coated nanoparticles with the size of about 40-60 nm that increases the concentration of drugs accumulated at the tumor site in response to low pH conditions. The optimal properties of the nanoparticles were investigated by analysing the antioxidant activity, sensitivity to pH, drug delivery in a low pH environment, and toxicity on cancer cells, thereby observing the possibility of inhibiting the migration of cancer cells. Results showed that the combination of DOX and the pH-sensitive redox nanoparticles not only increases anticancer in colorectal cancer (C-26), breast cancer (MCF-7) but also reduces bovine aorta endothelial cells (BAEC) and inhibits C-26 cell migration in vitro.Thepaper results reveal the application potential of the pH-sensitive redox nanoparticles in improving the effectiveness of cancer treatment.
Process evaluation for simultaneous determinationof Zidovudine and Lamivudineon the nanocarrier dendrimerby HPLC-PDA method
Authors:   Institute of Drug Quality Control - Ho Chi Minh City (IDQC-HCMC), Nguyen Thi Thinh ,   Institute of Applied Materials Science, Nguyen Cuu Khoa ,   Institute of Applied Materials Science
Published: June 2021

To determine Zidovudine (AZT) and Lamivudine (3TC) at the same time based on PAMAM dendrimer modified with Pluronic F127, application as anti-HIV drug control. A fast, accurate HPLC-PDA determination of AZT and 3TC with high reliability and selectivity has been developed and validated according to ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use) guidelines. The chromatography was carried out by C18 inversion column using the mobile phase of phosphate buffer solution of pH 2.5 - methanol (65:35), flow rate 1.0 ml/min, and detective wavelength 266 nm. The retention times of AZT and 3TC are 3.5 and 4.3 minutes, respectively with 3.15 resolution. Linearity ranges from 2.16 to 324.53 μg/ml for AZT, and from 2.54 to 152.10 μg/ml for 3TC (r=1.000); mean recovery 100.3% (RSD=0.36%) for AZT and 99.73% (RSD=0.50%) for 3TC. The evaluation results showed that the accuracy and suitability of the method in the analysis of active ingredients AZT and 3TC on the PAMAM G3.0-F127@AZT/3TC dendrimer nano carrier system are adequate.
Assessment of production capacity of three combinations of hybrid chickens
Authors:   Thuy Phuong Poultry Research Center, NIAS, Pham Thuy Linh , Nguyen Quy Khiem ,   Thuy Phuong Poultry Research Center, NIAS, Dang Dinh Tu ,   Thuy Phuong Poultry Research Center, NIAS, Nguyen Trong Thien ,   Thuy Phuong Poultry Research Center, NIAS, Le Ngoc Tan ,   Thuy Phuong Poultry Research Center, NIAS, Dao Thi Bich Loan ,   Thuy Phuong Poultry Research Center, NIAS, Vu Quoc Dung ,   Thuy Phuong Poultry Research Center, NIAS, Le Van Hung ,   Thuy Phuong Poultry Research Center, NIAS, Nguyen Thi Thu Hien ,   Thuy Phuong Poultry Research Center, NIAS, Nguyen Duy Trang ,   Thuy Phuong Poultry Research Center, NIAS
Published: June 2021

The research was conducted at the Pho Yen Chicken Research Station, Thuy Phuong Poultry Research Center, from January 2019 to August 2020 to evaluate the productive ability of the combinations of hybrid parent hens (♂TN1 x ♀TN2, ♂TN1 x ♀TN3, ♂TN1 x ♀TN32) and commercial chicken TN12, TN13, TN132. The results achieved: 3 parent hen hybrid combinations (♂TN1 x ♀TN2, ♂TN1 x ♀TN3, ♂TN1 x ♀TN32) have the egg yield/hen/68 weeks of age and feed consumption/10 eggs are 191.74 eggs and 2.30 kg; 196.32 eggs and 2.27 kg; 198.78 eggs and 2.25 kg respectively. The rate of embryo reaches 97.43, 97.07, and 97.67%. The commercial chickens TN12, TN13, TN132 have the body weight at 8 weeks of age and feed consumption/kg body weight gain are 2440.07 and 2.29 kg; 2360.12 and 2.26 kg; and 2407.15 g and 2.22 kg respectively.
Overcoming the problem of the lack of an immune response to cancer: A possible haptogenic approach to cancer immunotherapy
Authors: Riley Patrick
Published: June 2021

Cancer cells possess a number of unusual features, most of which are explicable in the light of the theory of epigenetic carcinogenesis. This includes the remarkable failure of malignant cells to evoke an immunological response from the host which is ascribed to their deviant behaviour resulting from anomalous expression of normal gene products. Given this background a possible approach to eliciting a specific anti-cancer immune response is proposed which involves selective haptenation of an identifiable target protein.
Estimates of Causality with Medical Image in Oncology
Authors: Martí-Bonmatí Luis
Published: June 2021

This work defines a research on data strategy focused on medical imaging and derived image biomarkers to critically assess the concept of causal inference and uncertainties. Computational observational studies will be valued to generate casual inference from real world data. Our main goal is to propose a scientific methodology that allows to estimate causalities from observational studies through quality control of large databases, definition of plausible hypotheses, using computational estimated models and artificial intelligence tools. The computational approach of radiology to precision medicine by using epidemiological strategies is based on causal inference studies relies on real-world data observational, longitudinal, case-control analysis designed (being case the presence, and control the absence of the event to be estimated). In this new research setting, we consider disease in classical epidemiology as phenotyping, response to treatment and final prognosis; and exposure equals to the presence of a radiomic, dynamic image biomarker or AI modeling solution. Research with data on which causality is to be inferred must control for recruitment of closed cases, in which the researcher does not intervene in the patient’s clinical history but works on databases, collecting data to be secondary used in generating consistent causalities.
Self-regulation as a predictor of Fear of Missing Out in emerging adulthood
Authors: Surya Dedy , Aulina Dara
Published: June 2021

The use of social media due to the development of technology has implications for the tendency to know the activity in their social circle. This tendency is called Fear of Missing Out (FoMO). This study aims to determine the relationship between self-regulation and FoMO in emerging adulthood. By using quantitative correlational research methods, this study involved 99 students of Department of Psychology, Malikussaleh University, Aceh, Indonesia with an emerging adulthood age range. The data in this study was collected using two scales, namely Self-Regulation Scale and FoMO Scale. Data analysis using Pearson Correlation. The results showed that there was no significant association between self-regulation variables and FoMO, indicated by the coefficient r = 0.544 and p = 0.000 < 0.05. This result means that there is a negative relationship between self-regulation and FoMO. Self-regulation contributed to FoMO in 4,00%. There were still 96% of other factors related to FoMO tendency. This research showed that self-regulation is too weak to predict FoMO in emerging adulthood
Empathy therapy to raise awareness of verbal bullying hazards
Authors: Hesty Dini Mai , Surya Dedy
Published: June 2021

The low awareness of verbal bullying hazard is caused by a low of empathy in individuals. Empathy therapy can be used to develop a sense of empathy, and it can raise awareness about verbal bullying hazard, thereby minimizing the tendency of verbal bullying. This study aims to see the effectiveness of empathy therapy for raised awareness of verbal bullying hazards. This research used a quantitative approach-quasi experimental (one group pretest-posttest design), with a purposive sampling technique, sample by six female participants between ages 17 and 19 in Gampong Paya Bujok Tunong. The instrument used in the research is the tendency scale of verbal bullying. The finding showed that there was a significant empathy therapy decreasing the tendency of verbal bullying.
Identification of Palestinian national identity (based on selected literary works)
Authors:   Al-Farabi KazakhNational University, Koptileuova D.T. , Zhumadilova A.E. ,   Al-Farabi KazakhNational University
Published: June 2021

This article examines the phenomenon of the division of Palestinian national identity in relation to Israel based on the literary works of Palestinian writers. To conduct the study, there were used a specific historical method of analysis and interpretation of original literary works to work with the sources. There were selected such works of fiction for the study as Sahar Khalifa’s Wild Thorns (1974), Gharib Haifaoui’s Snatcher of Sleep (2012) and Ibtisam Azim’s The Book of Disappearance (2014) and Said Kashua’s Dancing Arabs (2002). Based on these materials, it is concluded that the Palestinian nation is divided against Israel, from attempted assimilation to armed confrontation. It also concludes that there is short-term pragmatism and a willingness of mostPalestinians to maintain economic relations with Israel,with a consequent increase in thenumber ofArabs who speak Hebrew and are familiar with Jewish culture.
Nodular dermatitis (review)
Authors:   BIOTRON GROUP LLP, Puntus I.A. , Babak V.A. ,   BIOTRON GROUP LLP
Published: June 2021

The paper discusses the topic of the spread of a highly contagious transboundary emergent viral disease of cattle, nodular dermatitis; describes its etiology, epizootological data, pathogenesis, clinical signs and pathological changes, features of the course, diagnosis, differential diagnosis and treatment; the high growth rate of countries where the disease is registered is noted. The Republic of Kazakhstan is among them. The authors paid special attention to the significant economic damage caused by lumpy skin disease, as well as to the effectiveness of various schemes and methods of combating the disease, including stamping out, and in particular to specific prevention using two types of vaccines: heterologous virus vaccines, containing strains of sheeppox virus, and live attenuated virus vaccines from the Neethling strain.