bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Ibu Nyai for The Development of Local Community-Based Public Health Services
Authors: Arifin Samsul , Baharun Mukhammad , Saputra Rahmat
Published: July 2023

People with mental disorders are continually increasing every year. However, they are very few who seek treatment. The causative factor is the limited mental health services. One solution is to develop services based on Islamic boarding schools or pesantren. For pesantren, mental health is part of da'wah bil-irsyad or counseling.This paper aims to describe the role and potential of ibu nyai (female scholars of pesantren) in developing local community-based public health services. The study used a qualitative method with an ethnographic-hermeneutic approach. The results show that firstly, ibu nyai had the potential as leaders for female students, many are highly educated, some have colleges and health facilities, and some have sizeable social capital. Second, ibu nyai had a concern for health services because of her theological motivation and passion for da’wah. Third, ibu nyai has a powerful social network, which is expected to be helpful as a communication strategy for strengthening public health. Islamic boarding school-based public health has its own appeal and market share. This research is useful for developing public health science based on local wisdom. Masyarakat yang mengalami gangguan jiwa setiap tahun selalu meningkat. Mereka sedikit sekali yang berusaha mencari pengobatan. Faktor penyebabnya, karena terbatasnya layanan kesehatan mental. Salah satu solusinya, mengembangkan layanan yang berbasis pesantren. Bagi pesantren, kesehatan mental termasuk bagian dakwah bil-irsyad atau konseling. Tujuan tulisan ini untuk mendeskripsikan peran dan potensi ibu nyai dalam mengembangkan layanan kesehatan masyarakat berbasis komunitas lokal. Penelitian ini menggunakan metode kualitatif dengan pendekatan etnografi-hermeneutik. Hasil penelitian menunjukkan bahwa pertama, para ibu nyai berpotensi sebagai pemimpin bagi santri perempuan, banyak yang berpendidikan tinggi, ada yang memiliki perguruan tinggi dan fasilitas kesehatan serta memiliki modal sosial yang besar. Kedua, ibu nyai memiliki kepedulian terhadap layanan kesehatan karena motivasi teologis dan semangat khidmah dalam berdakwah. Ketiga, ibu nyai memiliki jejaring sosial yang sangat kuat, yang diharapkan bermanfaat sebagai strategi komunikasi dalam penguatan kesehatan masyarakat.  Kesehatan masyarakat berbasis pesantren memiliki daya tarik dan pangsa pasar tersendiri. Penelitian ini berguna untuk mengembangkan ilmu kesehatan masyarakat yang berbasis kearifan lokal.
Mapping Religious Activities and Pluralities in Houses: Case Study at Balun Village Lamongan
Authors: Subaqin Agus , Sudikno Antariksa , Wulandari Lisa Dwi , Santoso Herry
Published: July 2023

Religious activities are basic things that are indispensable in life and are primary needs that must be met. Religious plurality is a social reality in life; it is a challenge to create religious harmony, but on the other hand, it is prone to conflict. The study aims to map religious activities in the settlement of religious plurality, namely Islam, Christianity, and Hinduism, in Balun village, Lamongan. It applied an environment behavior study approach with a place-centered mapping method to find individuals or groups using and accommodating their behavior in a certain time and space, with aspects studied, namely religious activities, space, and time. Data were obtained from direct observation and interviews with purposive, systematic samples. The results showed that religious activities at home with religious plurality were mapped into two categories: the religious activities of individuals or groups according to their religion; and the religious activities by inviting citizens to their religion and different religions. Mapping of space use showed that the use of semi-public and public space in the home for religious activities result in flexibility in spatial functions and changes in sacred-profane spatial boundaries. The research contributed to the theoretical development of using shared space in the home and creating a space of tolerance in Balun village's religious life. Kegiatan keagamaan merupakan hal mendasar yang sangat diperlukan dalam kehidupan dan menjadi kebutuhan primer yang harus dipenuhi. Pluralitas agama termasuk realitas sosial dalam kehidupan; merupakan tantangan untuk menciptakan kerukunan umat beragama, namun di sisi lain rawan konflik. Kajian ini bertujuan untuk memetakan aktivitas keagamaan dalam penyelesaian pluralitas agama, yaitu Islam, Kristen, dan Hindu, di desa Balun, Lamongan. Penelitian ini menerapkan pendekatan kajian perilaku lingkungan dengan metode place-centered mapping untuk menemukan individu atau kelompok yang menggunakan dan mewadahi perilakunya dalam ruang dan waktu tertentu, dengan aspek yang dikaji yaitu kegiatan keagamaan, ruang, dan waktu. Data diperoleh dari observasi langsung dan wawancara dengan sampel purposif, sistematik. Hasil penelitian menunjukkan bahwa kegiatan keagamaan di hunian dengan pluralitas agama dipetakan menjadi dua kategori yaitu kegiatan keagamaan individu atau kelompok menurut agamanya; dan kegiatan keagamaan dengan mengajak warga untuk beragama dan berbeda agama. Pemetaan pemanfaatan ruang menunjukkan bahwa pemanfaatan ruang semi publik dan publik di rumah untuk kegiatan keagamaan mengakibatkan terjadinya fleksibilitas fungsi ruang dan perubahan batas ruang yang sakral-profan. Penelitian ini berkontribusi pada pengembangan teori pemanfaatan ruang bersama di rumah dan penciptaan ruang toleransi dalam kehidupan beragama di Desa Balun.
Chapter 1, Chronic Poverty Report 5 - Pandemic Poverty
Authors: Shepherd Andrew , Diwakar Vidya
Published: July 2023

This is chapter 1 of the Chronic Poverty Report 5 - Pandemic Poverty.
Universidad y Mediación: vertientes lingüística y socioeducativa.
University and Mediation: Linguistic and Socio-educational Aspects
Authors: González Vallejo Rubén
Published: July 2023

Este artículo centra su interés en el análisis de la mediación lingüística e intercultural en el sistema educativo escolar y universitario desde un posicionamiento empírico, ya que ambos enfoques comparten una interdependencia que no consiente la visión de una sin la otra durante el recorrido académico y profesional. Por ello, el volumen contempla reflexiones e investigaciones llevadas a cabo en Costa de Marfil, España, Estados Unidos y Francia, y que abarcan diferentes necesidades educativas: desde la situación del español en diferentes centros internacionales, junto con la creación de unidades didácticas, hasta el análisis de las aulas de adaptación lingüística dirigidas al alumnado extranjero y la percepción de los programas bilingües de varios centros públicos por parte de las familias.
Aulas temporales de adaptación lingüística (ATAL). Temporary linguistics adaptation classrooms (ATAL)
Authors: Galloso Camacho María Victoria
Published: July 2023

El sistema educativo español y andaluz debe seguir respondiendo con políticas de apoyo e integración a las necesidades educativas que presenta el alumnado inmigrante. Con el fin de apoyar la adquisición de competencias lingüísticas y comunicativas del alumno desconocedor de nuestro idioma, se crearon en Andalucía las Aulas Temporales de Adaptación Lingüística (ATAL). Este programa será el encargado de acoger en nuestros centros públicos andaluces al alumnado inmigrante con desconocimiento del español como lengua vehicular. El objetivo de este artículo es: abordar lo que dispone la ley en aquellos casos en los que los alumnos de origen extranjero no presenten el dominio necesario del castellano como lengua vehicular; qué actuaciones prevé la Junta de Andalucía en nuestro caso; y cómo se afronta la enseñanza de español como lengua extranjera para este colectivo minoritario en el programa ATAL.
Redesigning a Spanish undergraduate course considering affordability, diversity, equity, and learning styles. Plan and results. Rediseñar un curso de grado en español considerando la asequibilidad, la diversidad, la equidad y los estilos de aprendizaje. Plan y resultados
Authors: Fernández-Ulloa Teresa
Published: July 2023

En este artículo, mostraré cómo rediseñé el curso de grado Español-3710 (Temas de Literatura-Teatro barroco español), uno de los cursos del grado en español de la California State University, Bakersfield. Al rediseñar este curso, tenía cinco cosas en mente principalmente: 1) simplificar los materiales y hacerlos más asequibles a los estudiantes seleccionando materiales gratuitos y de acceso abierto; 2) dar más vida a las obras barrocas exponiendo a los estudiantes a las obras grabadas (unas veces en la versión clásica y otras con diferentes enfoques modernos); 3) continuar incorporando a las mujeres al canon de la literatura; 4) ofrecer a los estudiantes una oportunidad de aprendizaje activa y atractiva a través de las discusiones, los videos hechos con Flipgrid (ahora Flip) y los proyectos visuales creativos (mapas mentales y pósteres); y 5) seguir trabajando en las habilidades lingüísticas y discursivas que adquirieron en Español 3000 (Advanced Language Skills).
Recensión/Book Review Lenguas de España: combatiendo los prejuicios en torno a la realidad lingüística española
Authors: Fernández Suárez Aida
Published: July 2023

Reseña crítica sobre la obra Lenguas de España: Combatiendo los prejuicios en torno a la realidad lingüística española, de David Pinto Pajares. Publicada en Ediciones TREA (2022).
KONTRIBUSI NORMALISASI HYSTERETIC ENERGY TERHADAP DAMAGE INDEX DI PADA RESPONS INELASTIK STRUKTUR SDOF AKIBAT GEMPA
Authors: Widodo  , Mushthofa Malik
Published: July 2023

At a relatively large earthquake ground acceleration, the response of the structure is no longer elastic but is already in the inelastic phase where hysteretic energy is one of the elements of the earthquake energy content. In this phase, structural damage can not be avoided and structural damage is generally expressed in term of damage index DI. Studies on the contribution of normalization of hysteretic energy to the SDOF structure have been carried out. The inelastic behavior of the structure is simulated according to the behavior of Modified Takeda hysteretic model. In this study, two variables were used, namely the earthquake frequency content which is expressed in term of A/V ratio and the vibration period of the structure T. The results showed that the lower the value of the A/V ratio tends to result in a greater damage index DI, both for relatively rigid structures and for relatively flexible structures. The more flexible a structure tends to experience a greater damage index DI both for earthquakes high, medium and low frequency. The contribution of normalization of hysteretic energy to the damage index DI ranges from 10-30%, and the more flexible the structure, the contribution of normalization of hysteretic energy will be smaller. Furthermore, there is also a tendency that the lower the earthquake frequency content, the smaller the contribution of normalized hysteretic energy will accordingly.
ChatGPT for Digital Forensic Investigation: The Good, The Bad, and The Unknown
Authors: Scanlon Mark , Breitinger Frank , Hargreaves Christopher , Hilgert Jan-Niclas , Sheppard John
Published: July 2023

The disruptive application of ChatGPT (GPT-3.5, GPT-4) to a variety of domains has become a topic of much discussion in the scientific community and society at large. Large Language Models (LLMs), e.g., BERT, Bard, Generative Pre-trained Transformers (GPTs), LLaMA, etc., have the ability to take instructions, or prompts, from users and generate answers and solutions based on very large volumes of text-based training data. This paper assesses the impact and potential impact of ChatGPT on the field of digital forensics, specifically looking at its latest pre-trained LLM, GPT-4. A series of experiments are conducted to assess its capability across several digital forensic use cases including artefact understanding, evidence searching, code generation, anomaly detection, incident response, and education. Across these topics, its strengths and risks are outlined and a number of general conclusions are drawn. Overall this paper concludes that while there are some potential low-risk applications of ChatGPT within digital forensics, many are either unsuitable at present, since the evidence would need to be uploaded to the service, or they require sufficient knowledge of the topic being asked of the tool to identify incorrect assumptions, inaccuracies, and mistakes. However, to an appropriately knowledgeable user, it could act as a useful supporting tool in some circumstances.
The Impact of a School Dog on Children’s Social Inclusion and Social Climate in a School Class
Authors: Mombeck Mona , Albers Timm
Published: July 2023

Animal-assisted pedagogy (AAP) is well known in classroom practice, but scientific evidence is still lacking. At the same time, the biggest challenge in education systems worldwide is the social in-tegration of students. In a pre-post design, 30 heterogeneous students (16f/14m) from four different school classes (grades 5-7) were interviewed (problem-centred interview) about their social inclu-sion and their social climate in class before and after being taught selected subjects with a school dog (of different breeds) for one school term. At the second measurement point, they were also asked about their perception of AAP. The data was analysed both qualitatively (Kuckartz) and in terms of the number of quotes on the main topics using MAXQDA analysis software. The presence of a dog in the classroom leads to an improved social climate and more social integration. In ad-dition, the perception of the other students and the teacher changes to a more positive and friendly image. Through AAP, a new social role is added to the classroom, where caring and bonding are prioritised. Social interaction and norms are influenced and sterotypical and individual roles can be changed. Therefore, AAP can be a key to promoting social inclusion in the school environment.
Graph-Root: Prediction of Root-Associated Proteins in Plants Based on Graph Convolutional Network and Network Embedding Method
Authors: Chen Lei , Liu Siyang
Published: July 2023

The root system plays an irreplaceable role in plant growth. Its improvement can increase crop productivity. However, such system is still mysterious for us. The underlying mechanism has not been fully uncovered. The investigation on proteins related to the root system is an important means to complete this task. In the previous time, lack of root-related proteins makes it impossible to adopt machine learning methods for designing efficient models for the discovery of novel root-related proteins. Recently, a public database on root-related proteins was set up and machine learning methods can be applied in this field. In this study, we proposed a machine learning based model, named Graph-Root, for identification of root-related proteins. The features derived from protein sequences and one network were extracted, where the former features were processed by graph convolutional neural network and multi-head attention, and the later features abstracted the linkage between proteins. These features were fed into the fully connected layer to make prediction. The 5-fold cross-validation and independent tests suggested its good performance. It also outperformed the only one previous model, SVM-Root. Furthermore, the importance of each feature type and component in the proposed model was investigated.
MENGGALI MATURITAS DIRI: KAJIAN METAFORA PADA LIRIK LAGU ALBUM RIUH
Authors: Suryani Azizah , Nurjanah Neneng
Published: July 2023

This study examines the concept of self-maturity in the metaphor on the Riuh album created by Feby Putri by utilizing a qualitative approach using literature study techniques. The researcher focuses on the metaphors in Riuh's album through song lyrics which consist of ten songs. The data in this study is descriptive data that describes the concept of self-maturity in the metaphor of the song lyrics on the album 'Riuh'. The data source for this research is the verses in the song lyrics on the album 'Riuh'. The findings are 1) the researcher only took 4 different songs as research material, 2) there were 12 metaphorical data showing self-maturity in the lyrical verses studied
THE MYTH OF HOMECOMING in THE FILM PURANG BY AZHAR KINOI LUBIS A STUDY OF ROLAND BARTHES' SEMOTICS
Authors: Alfarobby Mufti Isror , Rengganis Ririe
Published: July 2023

ABSTRACT

The film that will be studied in this research is "Pulang" by Azhar Kinoi Lubis. The film, produced by KlikFilm Productions, RK23 and Canary studios, premiered on April 2, 2022. Carrying the genre of Indonesian family drama. The analysis in this study was conducted to describe the symbols in the film Pulang and identify the form of meaning contained in it, starting from the meaning of denotation, connotation and myth. The method used in this research is Content Analysis using Rolan Barthes' semiotic analysis theory. This study uses descriptive qualitative research to solve 3 main problems, including: (1) identifying the meaning of denotation, (2) identifying the meaning of connotation, (3) outlining the meaning of myth in the cinema entitled Pulang by director Azhar Kinoi Lubis. This research concludes that the denotative meaning in this film is about the amount of love that parents have for their children, the connotative meaning of each conflict that arises as a result of their respective egos, and the myth of going home to hometown is not only about going home to celebrate a meeting, but also about going home to celebrate a meeting. 

Keywords: film, semiotic, connotation, denotation, myth
PERSEPSI MAHASISWA DALAM PERKULIAHAN DARING PADA MATA KULIAH BAHASA INDONESIA DI UNIVERSITAS AMIKOM YOGYAKARTA
Authors: Fitra Romadani Anggit Tiyas , Yusi Kurniati
Published: July 2023

This study aims to describe student perceptions of the implementation of online lectures in the Indonesian language course at Amikom University, Yogyakarta. The results of the study show that most students have a positive perception of the implementation of online lectures in Indonesian courses. This perception is measured from three aspects, including aspects of the lecture process, aspects of lecturer competence, and aspects of facilities. In the aspect of the lecture process, most students gave a positive perception of the online lecture process. Students think that online lectures can train for independent learning and save on transportation costs. In terms of lecturer competence, most students agree that lecturers are competent so that online lectures can run smoothly. Meanwhile  the aspect of facilities, some students stated that facilities in the form of internet networks could be an obstacle in online lectures. However, students always get positive support from parents in online lectures
Critical Adaptability and Collaboration: A Student Reflection on Preparing for Scholarly Communication Librarianship
Authors: Lindsay Ruby
Published: July 2023

The quickly changing landscape of the scholarly communication ecosystem necessitates critical reflection on the preparedness of students entering this area of librarianship. A literature review of common roles, skills, and competencies of scholarly communication librarians followed by a personal reflection on learning and development as a Masters of Library and Information Studies (MLIS) student reveals that collaboration and adaptability are required to succeed in this area.
CSO and Media Contributions to the Fight Against Corruption in Ghana’s Extractive Sector: A Political Economy Analysis
Authors: Ofosu-Peasah Gideon
Published: July 2023

Estimates show that Ghana losses approximately 30 percent of domestic revenue to corruption. Although losses due to corruption in Ghana’s extractive sector have not yet been quantified, the sector is plagued with incidents of corruption despite the country's commitment to international conventions, transparency mechanisms and best practices. A concerted efforts by state and nonactors is key to ease this canker. Understanding the role of CSOs and media in exposing corruption, promoting oversight and identifying the enablers and obstacles to their work is key to informing practise in the development space. This study examines the role of CSOs and media in the fight against extractive sector corruption. It identifies political economy factors that enable or hinder them in exposing corruption. Lastly, it identifies practical suggestions for surmounting the identified adverse political and economic factors. The research examines two cases of corruption, based on a desktop review and a survey of 11 state and non-state actors. A direct association between the role of CSOs and media and the level of corruption were established. Coalition building, using legal suits, sustaining advocacy, collaborations between media and CSOs are some enabling political economy factors identified. Inadequate resources to sustain advocacy, excessive duplicity of roles amongst oversight institutions, vested interests in extractive sector, inadequate prosecution of offenders by the legal system, inadequate evidence-based policy solutions by government, inadequate political will, limited access to information; little or no funding for legal action, increasing CSO and media employee turnover rates, are identified as some key political economy factors militating against efforts towards stemming corruption in Ghana’s extractive sector. These findings provide reliable information for CSOs and media in development practice, informs advocacy design, evaluates and improves media and CSO effectiveness in ridding the extractive sector of corruption.
Defense and Attack Strategy Optimization for Reliability Systems with Virtual Components and Active Redundancy with a Game Theory Approach
Authors: Noormohammadi Gholamreza , najafi esmaeil , Safari Jalal , Sobhani Farzad Movahedi
Published: July 2023

Today, one of the most basic strategies for a government's survival is to defend sensitive places and resources, and to achieve this goal, strategic and efficient approaches are required. The goal of this research is to determine the best way to defend sensitive systems in which the defender tries to minimize the damage caused by the attacker while taking into account budget constraints and the space needed for defense equipment, and the attack tries to maximize the defender's injury. In this case, the defense creates a number of artificial targets in order to deceive the attacker, all while attempting to decrease the risk of damaging sensitive systems by not attacking them definitively. The goal's economic, human, and symbolic worth must be considered by both the defender and the attacker. The defender attempts to minimize projected harm and defense costs. The attacker aims to do as much damage as possible while keeping the attack's cost low. The attacker will "maybe" identify the targets because they are unable to identify the virtual targets. For the first time, a program model was developed that considers the possibilities for identifying virtual targets, reliability structures with mixed strategies (active and cold standby), non-homogeneous components in parallel series systems, and the game theory approach to finding equilibrium. A nonlinear layout is provided to optimize defense subsystems. The results are modeled and the results are evaluated in this research.
Successful use of HTF as a basal fertilization medium during SEcuRe mouse in vitro fertilization
Authors: Wigger Magdalena , Schneider Marco , Feldmann Anni , Assenmacher Sonja , Zevnik Branko , Tröder Simon E.
Published: July 2023

Objective: The ever-increasing number of genetically engineered mouse models highlights the need for efficient archiving and distribution of these lines. Sperm cryopreservation has become the preferred technique for the majority of these models due to its low requirement of costs, time and experimental animals. Yet, current in vitro fertilization (IVF) protocols either exhibit decreased fertilization efficiency for the most popular C57BL/6 strain, as recently demonstrated by us, or require costly and difficult-to-prepare media, respectively. As a result, we previously developed SEcuRe, a modified IVF protocol with low costs and high fertilization efficiency. The popular basal fertilization medium, Cook’s® proprietary “Research Vitro Fert” (RVF), used in this protocol has recently been discontinued. As a result, the application of the SEcuRe approach and other IVF protocols employing this medium has been severely limited.
Results: Here we show that human tubal fluid (HTF), a popular and widely available medium with a known composition, can be used as a basal fertilization medium instead of RVF. Comparison of RVF and HTF during 58 independent SEcuRe IVFs with cryopreserved C57BL/6 sperm revealed equal fertilization rates. In addition, we demonstrate that HTF has a substantially extended shelf-life by utilizing commercial HTF that was six months past its expiration date, yet did not affect fertilization during IVF or subsequent embryo development. This finding not only increases the economic value of our modified method, but also validates it once more. Our results demonstrate that common, shelf-life extended HTF can be used in SEcuRe IVF in place of now-discontinued RVF medium and ensure the applicability of the method, which we since termed SEcuRe 2.0. Our modified SEcuRe 2.0 strategy will assist researchers to efficiently archive and distribute genetically engineered mouse models in a cost-effective, easily adaptable, and 3R-compliant manner with minimal animal use.
Lens subluxation combined with Parry-Romberg Syndrome and a mini review
Authors: Tang Yating , Jing Qinghe , Jiang Yongxiang , Lu Yi
Published: July 2023

Introduction:
Parry-Romberg syndrome (PRS) is a rare progressive degenerative disorder of unknown etiology. Here we report a rare case of PRS combined with lens subluxation in Eye and ENT hospital of Fudan University, Shanghai. To our knowledge, it is the first reported case of PRS combined with lens subluxation that has been managed surgically with phacoemulsification and CTR placement and IOL implantation in Shanghai.
Patient and clinical findings:
A 60-year-old woman was referred for “right visual blur for 2 years” and had persistent right facial paralysis of unknown etiology since the age 12. She had right facial muscle atrophy and paralysis. Eye examination also showed the right eyelid pseudoptosis, enophthalmos, age-related cataract combined with lens subluxation existed in the right eye.
Diagnosis, intervention, and outcomes:
The patient was diagnosed as age-related cataract and lens subluxation in the right eye and progressive hemifacial atrophy (Parry-Romberg syndrome). We conducted a combined phacoemulsification, IOL and CTR implantation and pupilplasty surgery for the patient under general anesthesia and the postoperative UCVA was 20/30 and remained for 1 year’s follow up.
Conclusions
Here we reported a rare case of PHA combined with lens subluxation in China. After appropriate eye surgery, the patient achieved satisfying vision result in the right eye.
From colonial clusters to colonial sheaths: analysis of Microcystis morphospecies in mesocosm by imaging flow cytometry
Authors: Zhumakhanova Adina , Mirasbekov Yersultan , Malashenkov Dmitry V. , Davidson Thomas A. , Levi Eti Ester , Jeppesen Erik , Barteneva Natasha S.
Published: July 2023

The alarming increase in the frequency of blooms of Microcystis in freshwater lakes and reservoirs occurs worldwide, with major implications for their ecosystem functioning and water quality. We applied FlowCAM-based imaging flow cytometry together with PCR and sequencing to get a comprehensive picture of the seasonal development of Microcystis community in a long-term running lake mesocosm experiment. The IFC analysis with manual taxonomic classification confirmed early findings with a machine learning algorithm that some Microcystis morphospecies completely disappeared and re-appeared along the mesocosm experiment timeline. This observation supports the hypothesis of the main transition pathways of colonial Microcystis. For the first time, colonial mucilaginous envelopes or sheaths were reported as separate entities, and not as a part of Microcystis colonies. The colonial sheaths may contain a few single Microcystis cells and reach significant numbers (thousands) during a cyanobacterial bloom. We also found that non-identifiable colonial small clusters of Microcystis cells are an important stage in the complex mosaic of a Microcystis bloom and are associated with the development of colonial forms. Our findings were validated by the principal component analysis coupled with the constructed associative matrices. We hypothesize that colonial sheaths may be crucial at Microcystis spp. dispersal and represent one of the stages of colonies development.
Geographic distribution and impacts of climate change on the suitable habitats of Rhamnus utilis in China
Authors: guiquan Song , Jiali Feng , shuai Gong , wenya Hao , xiangkun Kong , Sheng Zhao , yueling Zhao , xuelian Jiang
Published: July 2023

Rhamnus utilis (Rhamnaceae) is an ecologically and economically important tree species. The growing market demands and recent anthropogenic impacts to R. utilis forests has negatively impacted its populations severely. However, little is known about the potential distribution of this species and environmental factors that affect habitat suitability for this species. By using 219 occurrence records along with 51 environmental factors, present and future suitable habitat were estimated for R. utilis using MaxEnt modelling; the important environmental factors affecting its distribution were analyzed. The results indicate that January water vapor pressure, the normalized difference vegetation index, mean diurnal range, and precipitation of the warmest quarter represented the critical factors explaining the environmental requirements of R. utilis. The potential habitat of R. utilis included most provinces from central to southeast China. Under climate change scenario SSP 245, MaxEnt predicted a cumulative loss of ca. 0.73 × 105 km2 for suitable habitat for R. utilis by the 2060s while an increase of ca. 0.65 × 105 km2 occurred in the 2010s. Furthermore, under this climate change scenario, the suitable habitat will geographically expand to higher elevations. The findings of our study provide a foundation for targeted conservation efforts and inform future research on R. utilis. By considering the identified environmental factors and anticipating the potential impacts of climate change, conservation strategies can be developed to preserve and restore suitable habitats for R. utilis. Protecting this species is not only crucial for maintaining biodiversity but also for sustaining the economic benefits associated with its ecological services.
Exploring challenges and best practice in Memory Assessment Services in England and Wales – a national survey and case study approach
Authors: Smith Sarah Jane , Surr Claire
Published: July 2023

Background: To explore the design, delivery models and identify good and innovative practices in Memory Assessment Services (MAS) in England and Wales.
Methods: A two-stage service evaluation comprising 1) on-line survey of MAS providers to identify features of the commissioning models, service design, delivery, and challenges alongside examples of good/innovative practice; 2) qualitative case studies using video/telephone interviews with key staff and people who had used the service.
Results: The 49 respondents to the survey reported a shift in delivery of MAS services post COVID and identified key areas for improvement, including need for specialist staff, support for MCI and rarer dementias, and capacity for post diagnostic support. The 15 case studies illustrated good practice and innovation focusing on post diagnostic support, equity of access, working with external services/service location, MCI and rarer dementia and involving specialist staff.
Conclusions: The evaluation speaks to the importance of (re)evaluation of services to identify local need and the importance of commissioning based on local need and innovative approaches that my sit outside of ‘typical’ MAS pathways.
2D Capsule Networks Detect Perceived Changes in Infant∼Environment Relationship Reflected in 3D Movement Dynamics
Authors: khodadadzadeh Massoud , Sloan Aliza T. , Jones Nancy Aaron , Coyle Damien , Kelso J. A. Scott
Published: July 2023

Can infant exploration and causal discovery be detected using Artificial Intelligence (AI)? A recent experiment probed how purposeful action emerges in early life by manipulating infants’ functional connection to an object in the environment (i.e., tethering one foot to a colorful mobile). Vicon motion capture data from multiple infant joints were used here to create Histograms of Joint Displacements (HJDs) to generate pose-based descriptors for 3D infant spatial trajectories. Using HJDs as inputs, machine and deep learning systems were tasked with classifying the experimental state from which snippets of movement data were sampled. The architectures tested included k-Nearest Neighbour (kNN), Linear Discriminant Analysis (LDA), Fully connected network (FCNet), 1D-Convolutional Neural Network (1D-Conv), 1D-Capsule Network (1D-CapsNet), 2D-Conv and 2D-CapsNet. Sliding window scenarios were used for temporal analysis to search for topological changes in infant movement related to functional context. kNN and LDA achieved higher classification accuracy with single joint features, while deep learning approaches, particularly 2D-CapsNet, achieved higher accuracy on full-body features. For each AI architecture tested, measures of foot activity displayed the most distinct and coherent pattern alterations across different experimental stages (reflected in the highest classification accuracy rate), indicating that interaction with the world impacts the infant behaviour most at the site of organism∼world connection. Pairing theory-driven experimentation with AI tools thus opens a path to developing functionally-relevant assessments of infant behaviour that are likely to be useful in clinical settings.
Employing electrochemically derived pH gradients for Lab-on-PCB protein preconcentration implementations
Authors: Maxted Grace , Estrela Pedro , Moschou Despina
Published: July 2023

Protein preconcentration is an essential sample preparation step when analysing samples where the targeted proteins are in low concentrations, such as bodily fluids as well as water or wastewater. Nonetheless, very few practical implementations of miniaturized protein pre-concentration devices have been demonstrated in practice and even fewer in integration with other microanalytical steps. In this paper we propose for the first time a miniaturized isoelectric focusing-based protein-preconcentration device based on electrochemically derived pH gradients, rather than existing chemical reagent approaches. That way we are reducing the need for additional chemical reagents to zero, whilst enabling the device incorporation in a seamlessly integrated full protein analysis microsystem via Lab-on-PCB technology. We apply our previously presented Lab-on-PCB approach to quantitatively control the pH of a solution at the vicinity of planar electrodes using the electrochemical generation of acid through redox-active self-assembled monolayers. The presented device was comprised of a printed circuit board with an array of gold electrodes which was functionalised with 4-Aminothiophenol; this formed a self-assembled monolayer which was electropolymerised to improve its electrochemical reversibility. Protein preconcentration was performed in two configurations, one of which was open and required the use of a holder to suspend a well of fluid above the electrodes, and another which used microfluidic channels to enclose small volumes of fluid. Reported here is the data for protein preconcentration in both these forms with a quantitative concentration factor shown for the open form and qualitative proof shown for the microfluidic.
RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding.
Authors: Lin Ying , Wu Yun , Zhang Qiangzu , Tu Xunwei , Chen Sufang , Pan Junfan , Xu Nengluan , Lin Ming , She Peiwei , Niu Gang , Chen Yusheng , Li Hongru
Published: July 2023

Background: Ceramide metabolism is crucial in the progress of brain metastasis (BM). However, it remains unexplored whether targeting ceramide metabolism may arrest BM.
Methods: RNA sequencing was applied to screen different genes in primary and metastatic foci and whole-exome sequencing (WES) to seek crucial abnormal pathway in BM+ and BM-patients. Cellular arrays were applied to analyze the permeability of blood-brain barrier (BBB) and the activation or inhibition of pathway. Database and Co-Immunoprecipitation (Co-IP) assay were adopted to verify the protein-protein interaction. Xenograft and zebrafish model were further employed to verify the cellular results.
Results: RNA sequencing and WES reported the involvement of RPTOR and ceramide metabolism in BM progress. RPTORwas significantly upregulated in BM foci and increased the permeability of BBB, while RPTOR deficiency attenuated the cell invasiveness and protected extracellular matrix. Exogenous RPTOR boosted the SPHK2/S1P/STAT3 cascades by binding YY1, in which YY1 bound to the regions of SPHK2 promoter (at -353 ~ -365 nt), further promoting the expression of SPHK2. The latter was rescued by YY1 RNAi. Xenograft and zebrafish model showed that RPTOR blockade suppressed BM of non-small cell lung cancer (NSCLC) and impaired the SPHK2/S1P/STAT3 pathway.
Conclusion: RPTOR is a key driver gene in the brain metastasis of lung cancer, which signifies that RPTORblockade may serve as a promising therapeutic candidate for clinical application.
Genome-Wide Analysis of the Lateral Organ Boundaries Domain (LBD) Gene Family in Sweet Potato
Authors: Shi lei , Lin Xiongjian , Tang Binquan , Zhao Rong , Wang Yichi , Lin Yingyi , Wu Liangliang , Zheng Chao , Zhu Hongbo
Published: July 2023

Background
Sweet potato (Ipomoea batatas (L.) Lam.) serves as an important food source for human beings. The lateral organ boundary (LOB) structural domain (LBD) genes are a family of genes encoding plant-specific transcription factors that play important roles in regulating plant growth and development, nutrient metabolism, and environmental stresses. However, the function of IbLBD genes in sweet potato remains unclear.
Results
In this study, We identified a total of 53 IbLBD genes in sweet potato. Genetic structure showed that most of the IbLBD genes contained only two exons. Based on the phylogenetic analysis, the IbLBD gene family was classified into class I (45, with the largest number of Ia genes (20)) and class II (8), both classes of proteins contained relatively conservative Motif1 and Motif2 domains. The sweet potato LBD gene was also analyzed regarding its chromosomal distributions, gene duplications, promoters and PPI network. In addition, gene expression profiling and real-time quantitative PCR analysis showed that the expression of 12 IbLBD genes differed in six different tissues and different abiotic stresses. The IbLBD genes of Class I were mainly expressed in the primary root, pencil root, and leaves, while Class II genes were mainly expressed in the different roots of sweet potatoes. Besides the expression pattern analysis of salt and drought treatment plants showed that abiotic stress treatment could significantly induce the expression of IbLBD genes. Specific expression patterns of IbLBD genes under salt and drought stresses suggest their important role in resisting adverse external environments.
Conclusions
Taken together, the molecular basis of LBD genes in sweet potato was analyzed from multiple perspectives, which provides a theoretical basis to further investigate the functions of sweet potato LBD genes.
Predicting Fracture Risk for Chinese Elderly Osteoporosis Patients by Hybrid Model
Authors: Liu Menghan , Wei Xin , Xing Xiaodong , Ma Zicheng , Ren Jiwu , Gao Xiaofeng , Xu Ajing
Published: July 2023

Background: In China, there are many elderly people who suffer from osteoporosis. Fractures, the most serious complication of osteoporosis, can greatly affect people’s quality of life and add pressure to the social pension system. Thus, predicting fracture risk in elderly patients with osteoporosis is imperative, which allows for timely treatment and ameliorates the strain on healthcare resources. Machine learning (ML) models based on Electronic Health Records (EHR) can be contracted to predict fracture risk.
Methods: Data of patients with osteoporosis were extracted from the Electronic Health Records (EHR) in Xinhua Hospital. Demographic and clinical features that are readily available from EHR were used to develop prediction models based on 12 independent ML algorithms (Naïve Bayes classifier [BP], logistic regression [LR], decision tree [DT], k-nearest neighbors [KNN], support vector machine [SVM], random forests [RF], extremely randomized trees [ERT], gradient-boosted decision trees [GBDT], adaptive boosting [AdaBoost], categorical boosting [CatBoost], extreme gradient boosting [XGBoost], multilayer perceptron [MLP]) and 3 hybrid ML models (XGBoost + MLP, XGBoost + LR, XGBoost + SVM). A comprehensive importance score was designed to interpret features from several aspects.
Results: A total of 8530 patients with osteoporosis were included for analysis, of which 1090 cases (12.8%) were fracture patients. The hybrid XGBoost and SVM model had the best predictive performance in terms of accuracy and precision (above 90%) among all models. We obtained 20 important features according to the comprehensive importance score, which represents high-risk factors for fractures and was interpreted from a clinical point of view.
Conclusions: The hybrid XGBoost and SVM model can be reliable tools for predicting the risk of fracture in patients with osteoporosis. And the hybrid model had the best predictive performance, which can be used to assist clinicians in identifying high-risk fracture patients and implementing early interventions.
Cannabis-fruit/vegetable syndrome: an unusual case without pollen co-sensitization
Authors: Wang Joanne , Lam Godfrey , Mak Raymond
Published: July 2023

Background:
Cannabis use has become increasingly popular since its legalization. In 2022, 19% of Canadians over 16 years of age report using cannabis within the past 30 days1. Cannabis is associated with an extensive spectrum of cross-reactivity with fruits and vegetables through a phenomenon known as cannabis-fruit/vegetable syndrome2. While most patients are co-sensitized with cross-reactive pollen, we present a unique case of cannabis-fruit/vegetable syndrome without birch pollen co-sensitization.
Case Presentation:
Since 2021, a 26-year-old female with intermittent cannabis smoking began noticing IgE mediated symptoms when eating previously tolerated fruits within the birch pollen family. Her first instance was with fresh cherries where she instantly experienced ocular/throat pruritus and generalized urticaria. In 2022, she had similar reactions to fresh peaches and raspberries. Concurrently, she began experiencing immediate ocular/throat pruritus with Cannabis sativa but not with Cannabis indica. Her fresh fruit skin test was positive to nectarine (10mm), plum (6mm), raspberry (12mm), blackberry (6mm), and both Cannabis sativa (7mm) and indica (11mm). Her environmental panel was negative to common grass, tree and weed pollens. She was prescribed an epinephrine autoinjector given her systemic symptoms.
Conclusion:
Multiple potential allergens including non-specific lipid transfer proteins (nsLTP), thaumatin-like protein, ribulose-1,5-bisphosphate carboxylase oxygenase, and oxygen evolving enhancer protein are thought to be contributors to cannabis allergies3. Of these, nsLTP is a pan-allergen found ubiquitously throughout the plant kingdom, potentially explaining cross activities between cannabis, fruits, and vegetables. Our case of cannabis-fruit/vegetable syndrome in an otherwise non-atopic individual is interesting as her skin testing showed no reaction against common pollens, specifically birch, a well-known aeroallergen to cross-react with cherries, peaches, and plums. These findings suggest the patient became sensitized to fruits through cannabis use. With increasing cannabis accessibility, more awareness in the medical community is necessary on allergic implications of cannabis use.
Outcomes of allogeneic hematopoietic stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma
Authors: Kato Koji , Sugio Takeshi , Ikeda Takashi , Yoshitsugu Kanako , Miyzaki Kana , Suzumiya Junji , Yamamoto Go , Kim Sung-Won , Ikegame Kazuhiro , Uehara Yasufumi , Mori Yasuo , Ishikawa Jun , Hiramoto Nobuhiro , Eto Tetsuya , Nakazawa Hideyuki , Kobayashi Hikaru , Serizawa Kentaro , Onizuka Makoto , Fukuda Takahiro , Atsuta Yoshiko , Suzuki Ritsuro
Published: July 2023

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) are curative treatment modalities for diffuse large B-cell lymphoma (DLBCL) because of the intrinsic graft-versus-lymphoma effect. However, limited information is available regarding which patients with relapsed or refractory DLBCL are likely to benefit from allo-HSCT. We retrospectively analyzed data from 1,268 DLBCL patients who received allo-HSCT. The overall survival and progression-free survival (PFS) rates were 30.3% and 21.6% at 3 years, respectively. Multivariate analysis revealed that stable or progressive disease at transplantation, male patient, poorer performance status at transplantation and shorter interval from previous transplantation were associated independently with a lower PFS. Four prognostic factors were used to construct a prognostic index for PFS, predicting 3-year PFS of 55.4%, 43.7%, 20.4% and 6.6%, respectively. The prognostic model predicted relapse rates following allo-HSCT accordingly (P < 0.0001), whereas did not predict transplantation-related mortality (P = 0.249). The prognostic index can identify a subgroup of DLBCL patients whobenefit from allo-HSCT and it is worthwhile to evaluate whether this model is also applicable to patients undergoing allo-HSCT in cases of relapse after chimeric antigen receptor engineered T-cell therapy, although the application of allo-HSCT has been declining with the increase of novel immunotherapies.
Separablilty of metric measure spaces and choice axioms
Authors: Howard Paul
Published: July 2023

We prove that the assertion “For every metric space (X, d ) with a Borel measure μ such that the measure of every open ball is positive and finite, (X, d ) is separable.” lies strictly between the axiom of choice for countable collections of finite sets and the axiom of choice for countable collections of sets in deductive strength in set theory without the axiom of choice. This gives an answer to a question of Dybowski and Gorka [1].