bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptation of trend analysis over a small-scale region for assessing climate change parameters
Authors: P Vincent , Baanu Bharani , U Brindha , C Ananth , K Jeyasubramanian
Published: April 2024

Several natural and anthropogenic activities mainly escalate the demand for water and food and develop implications for their availability. Hence, it is necessary to analyse the natural and man-made changes for managing resources precisely. This study focuses on assessing the trends of climatic factors such as rainfall and temperature using the Mann–Kendall (MK) test and innovative trend analysis (ITA) for the agricultural cropping seasons. The findings revealed that a statistically insignificant increasing trend in rainfall is observed for all three cropping seasons (i.e.) Kuruvai/Samba (June–September), Thaladi/Navarai (October–January), and Sornavari (February–May), while the mean temperature shows a significantly increasing trend for all three cropping seasons. The results obtained using the MK test are compared with those of the ITA test to identify the reliable trend technique for climatic factor analysis of small regions. To manage the impacts of climate change and develop sustainable conditions in agriculture, this micro-level study assists the decision makers to prefer suitable trend analysis techniques and helps in identifying the climate change adaptation strategies for small regions. Also, this study is helpful for rural farmers to increase their adaptability conditions with regard to the climate change impacts as they are the frontline victims of climate change.
Experimental study of the effect of rectangular debris blockage on the scour hole development around a cylindrical bridge pier
Authors: Khalili Ali Mahdian , Hamidi Mehdi , Dadamahalleh Pouria Akbari
Published: April 2024

Studying the influences of the debris settled by the flood upstream of the bridge pier on the scour is important. In the present study, experimental tests were performed as four models including the bridge pier, the bridge pier with buried debris, the bridge pier with the free debris, and the bridge pier with free debris and the bed sill with the downstream gap equal to 0, 1, 2, 3, and 4 times of pier diameter. The results showed that buried debris increased the maximum length of the scour hole (ls), and the maximum width of the scour hole (ws) by about 50, and 180% respectively in comparison with the alone pier. It resulted that buried debris has a more increased effect than free debris. Free debris at low submergence ratios reduces ls by up to 27%, and in high submergence ratios increases it by up to 37%. Also, free debris increases ws in all submergence ratios, which is by up to 127% for the critical case compared to the case without debris. At all distances, the bed sill reduces ls and ws, and the best performance for reducing ls and ws is when it is attached to the bridge pier.
Wkład kardynała Stefana Wyszyńskiego w przygotowania do Soboru Watykańskiego II
Authors: Białkowski Michał
Published: April 2024

Prymas Stefan Wyszyński odegrał kluczową rolę w przygotowaniu Kościoła w Polsce do obrad Soboru Watykańskiego II. Z inicjatywy kardynała już w kwietniu 1959 roku powołana została Komisja Soborowa Episkopatu Polski. Gremium to – w ścisłej współpracy z pryma- sem – przygotowało listy pasterskie, w których wyjaśniano problematykę soborową. Jako metropolita gnieźnieński i warszawski skierował obszerne vota, w których zawarł propozycje i sugestie dotyczące tematyki obrad przyszłego soboru. Hierarcha uczestniczył również w pracach Papieskiej Centralnej Komisji Przygotowawczej, której członkiem został jeszcze w czerwcu 1960 roku. Na Katolickim Uniwersytecie Lubelskim w sierpniu 1961 roku patronował specjalnej konferencji naukowej. Do oryginalnych działań prymasa Polski należały Maryjne czuwania modlitewne ujęte w ramy czteroletniego programu duszpasterskiego „Czuwań Soborowych”. Były one jednym z najważniejszych przygotowań do duchowego prze- życia obrad soborowych realizowanym na szczeblu ogólnopolskim, diecezjalnym, dekanalnym, parafialnym i rodzinnym.
Otwarcie Soboru Watykańskiego II w perspektywie zniewolonej Polski
Authors: Żaryn Jan
Published: April 2024

Otwarcie Soboru Watykańskiego II było wydarzeniem o znaczeniu historycznym nie tylko z perspektywy Kościoła powszechnego. Jednak w tym samym czasie, gdy Sobór rozpoczynał obrady, Kościół w Polsce, aktywnie uczestnicząc w pracach przedsoborowych i soborowych, kierowanych przez prymasa Stefana Wyszyńskiego, musiał skupić się na odnowionej obronie katolicyzmu w przestrzeni publicznej zagrożonego wzmożoną antykościelną polityką władz komunistycznych. Paradoksalnie otwartość Jana XXIII na dialog m.in. z lewicowymi nurtami ideowymi na Zachodzie, a także z państwami komunistycznymi na Wschodzie zbiegła się w czasie w PRL-u z powrotem do praktyk stalinowskich w odniesieniu do polityki religijnej, prymasa i Kościoła. Prymas Stefan Wyszyński i polscy biskupi musieli więc pogodzić wewnętrzną potrzebę suwerennego uczestnictwa w ogólnoświatowym i ponadpokoleniowym wydarzeniu w dziejach Kościoła powszechnego z jednoczesną, przyziemną reakcją na re- presje i prowokacje organizowane przez władze komunistyczne wobec Polaków – katolików świeckich, duchownych i zgromadzeń zakonnych. Komuniści, manipulując otwarciem się papieża na komunistyczny Wschód, mogli w ten sposób winą za złe stosunki państwo-Kościół w Polsce obarczać kard. Wyszyńskiego, który rzekomo odrzucał dialog z nimi.
Kardynał Stefan Wyszyński prekursorem reformy i odnowy liturgii w Kościele posoborowym w Polsce
Authors: Janiec Zdzisław
Published: April 2024

Sobór Watykański II zapoczątkował dzieło reformy i odnowy liturgii w Kościele powszechnym. W posoborowy trend włączył się Kościół w Polsce z kard. Stefanem Wyszyńskim. Stąd jemu został poświęcony niniejszy tekst, którego problem streszcza się w pytaniach: na ile prymas Wyszyński jest prekursorem reformy i odnowy liturgii w Kościele posoborowym w Polsce i jaki jest jego wkład w to dzieło? 

Referat ustrukturyzowany został w formie tryptyku. W pierwszej części prymas Wyszyński został ukazany jako wzorowy liturg i kompetentny liturgista. Druga część prezentuje realizację reformy liturgicznej, zaś trzecia – dokonania w dziedzinie odnowy liturgicznej. W opracowaniu tekstu posłużono się metodą analizy tekstów i syntezy. 

Niniejsze studium przedstawia prymasa Polski jako zasłużonego prekursora reformy i odnowy liturgii Kościoła w Polsce. Ukazuje jego cenny wkład w to dzieło, które do dziś stanowi trwałą podstawę religijnej kultury katolickiego społeczeństwa.
Działalność dydaktyczna i badawcza ks. dr. Józefa Glempa
Authors: Góralski Wojciech
Published: April 2024

Ksiądz dr Józef Glemp, absolwent Wydziału Obojga Praw Papieskiego Uniwersytetu Laterańskiego w Rzymie, a także Studium Administracji Kościelnej przy Kongregacji Soboru oraz Studium Rotalnego, pełni od 1967 roku absorbujące funkcje w Sekretariacie Prymasa Polski. Rok później podjął również pracę dydaktyczną na Wydziale Prawa Kanonicznego Akademii Teologii Katolickiej w Warszawie, gdzie prowadził ćwiczenia z prawa rzymskiego oraz kanonicznego prawa małżeńskiego, które kontynuował do roku 1979, kiedy to został mianowany przez Jana Pawła II biskupem warmińskim. 

Znaczącą pomocą dydaktyczną dla studentów był opracowany przez niego skrypt Lexiculum prawa rzymskiego (Warszawa 1974).Prowadził pracę badawczą, której owocem jest ponad 50 publikacji, które wzbogaciły piśmiennictwo kanonistyczne. Wśród tych tekstów dostrzec można następujące nurty tema- tyczne: Kościół lokalny i partykularny, małżeństwo, sądownictwo kościelne, historia prawa kanonicznego w Polsce, a w szczególności biografistyka. Prace te znamionuje oryginalność w ujęciu poruszanych zagadnień (w szczególności z zakresu prawa małżeńskiego), jasność wywodów oraz stosowanie właściwych metod.
Nauka i kontemplacja – o dwóch inicjatywach prymasa Józefa Glempa. Rzecz o Towarzystwie Uniwersyteckim Fides et Ratio oraz Kapitule Kolegiackiej Kampinosko-Bielańskiej
Authors: Żukowska-Gardzińska Dominika
Published: April 2024

Mało znanym wątkiem biograficznym jest zaangażowanie prymasa Józefa Glempa w powstanie w archidiecezji warszawskiej nowych wspólnot, towarzystw i kolegiat. Przykładem może być nieoczywista z pozoru więź, jaka z inicjatywy prymasa powstała między Towarzystwem Uniwersyteckim Fides et Ratio i Kapitułą Kolegiacką Kampinosko-Bielańską. Poprzez działalność obydwu instytucji podczas 20 latach ich istnienia widać wyraźnie, że dzieła te były przez prymasa Glempa przemyślane i kompatybilne nie tylko w założeniu. To poprzez takie właśnie dzieła i inicjatywy prymas ukazuje się jako pasterz, który rozumiał potrzebę łączenia modlitwy i religijnej refleksji z namysłem intelektualnym oraz pracą naukową.
„Nie będziesz miał bogów cudzych przede Mną” (Wj 20,3). Przesłanie moralne kardynała Stefana Wyszyńskiego, prymasa Polski
Authors: Dziuba Andrzej
Published: April 2024

Pierwsze przykazanie Dekalogu odnosi się do prawdy samego Boga. Człowiek ze swej natury już od początku swego świadomego życia nosi w sobie potrzebę odnoszenia się do Boga. Jest uznawany pozytywnie za Boga Stwórcę. Kardynał Wyszyński zwraca uwagę, że trzeba od początku widzieć w Nim także Ojca w Chrystusie. W kontekście tej wielkości Boga pojawia się również, jak mówi opis biblijny, pragnienie przebóstwienia człowieka, aby człowiek chciał zastąpić Boga. Następnie dochodzi do tego deifikacji materii, która jest zaprzeczeniem przykazania: nie mieć innych bogów. Taki sposób myślenia prowadzi do zanegowania Boga i poważnego zachwiania zaufania do Niego. W tym kontekście pojawiają się różne formy ateizmu. Z kolei człowiek zaczyna budować inną koncepcję wolności i inaczej z niej korzystać. Życie człowieka według Dekalogu nie jest zadaniem łatwym. Niejednokrotnie człowiek musi przezwyciężyć różne pokusy, jakie oferuje pogański świat, wraz z różnymi przemianami. A jednak różne postawy wobec tego zjawiska mogą prowadzić do dojrzałości wiary.
Rady ewangeliczne w życiu świeckich konsekrowanych według bł. Stefana Wyszyńskiego
Authors: Hadryś Jacek
Published: April 2024

Artykuł został poświęcony nauczaniu bł. Stefana Wyszyńskiego na temat życia według rad ewangelicznych, które było skierowane do członkiń Instytutu Świeckiego Pomocnic Maryi Jasnogórskiej Matki Kościoła. W związku z powyższym analizie zostało poddane nauczanie Wyszyńskiego w tymże aspekcie, a obejmujące lata 1943-1981, czyli okres od pierwszego spotkania ks. Wyszyńskiego z członkiniami powstającego Instytutu aż do jego śmierci. Zachowując klimat i specyfikę ascetycznych konferencji i rozważań kard. Wyszyńskiego, zaprezentowano uzasadnienie życia konsekrowanego, a następnie nauczanie dotyczące konsekrowanej czystości, ubóstwa oraz posłuszeństwa. W zakończeniu artykułu umieszczono podsumowanie badań oraz podano tezy i wnioski z nich wypływające, wskazując m.in. na fakt, iż zachowywanie przez Pomocnice rad ewangelicznych Wyszyński traktował nie tylko jako środek służący ich osobistemu uświęceniu, ale również jako przygotowanie do owocnego pełnienia przez nie misji ewangelizacyjnej.
Repercussões do desmame precoce para a saúde dos recém nascidos e lactentes
Authors: Pinto Rayanne Rocha de Oliveira , Godinho Jannaína Sther Leite , Souza Alessandra da Silva , Silva Eliara Adelino da , Vieira Carolina de Lourdes Julião , Rodrigues Lília Marques Simões
Published: April 2024

A falta de amamentação assim como sua interrupção precoce (antes dos seis meses) e a entrada de outros alimentos na dieta do lactente, nesse período, são comuns, trazendo consequências sérias para a saúde do bebê, que ficam mais expostos a agentes infecciosos, em contato com proteínas estranhas, lhes prejudicando a digestão e também a assimilação de elementos nutritivos, etc. O objetivo do trabalho foi estudar os principais motivos e consequências do desmame precoce para a saúde das crianças, evidenciando a importância do Aleitamento Materno (AM). Para tanto foi realizada uma revisão de literatura, onde se rastreou e, posteriormente selecionou autores que embasassem o objetivo proposto. O estudo observou que o desmame precoce pode ser bastante prejudicial para a saúde dos recém nascidos e lactentes, e que os principais fatores desse desmame são as crenças e tabus ainda existentes sobre o leite materno, problemas nos mamilos, trabalho da mãe fora de casa, baixa escolaridade e baixa renda da mãe, idade da mãe, e bebês que nasceram com a saúde afetada, tendo que ser internados em Unidades de Tratamento Intensivo Neonatal (UTINs). O estudo verificou também que para mulher manter o aleitamento materno exclusivo necessitará do apoio da família, da sociedade, e, principalmente dos profissionais de saúde, destacando-se o profissional de enfermagem.
Palavras-chave: Aleitamento Materno; Desmame Precoce; Assistência de Enfermagem.
Aspectos subjetivos na abordagem educativa ao sujeito hipertenso e diabético: revisão integrativa
Authors: Brezolin Christhian Antônio , Teixeira Enéas Rangel , Silva Jorge Luiz Lima da , Carvalho Rozana Neves Guimarães de , Barbosa Kevin Sousa
Published: April 2024

Introdução: identificar e discutir com base na revisão da literatura científica aspectos subjetivos de sujeitos hipertensos e diabéticos no contexto da educação em saúde. Materiais e método: revisão integrativa da literatura com coleta de dados nas bibliotecas Medline, Lilacs, BDenf, Scielo, BVS e Pubmed, no período de 2017 a novembro de 2022, utilizando os descritores Hypertension, Diabetes Mellitus e Health Education, com textos publicados no período 2014-2022. Os artigos foram lidos e os conteúdos tabulados e interpretados. Resultados: ao serem aplicados os critérios de inclusão e exclusão foram obtidos 22 artigos, cujas análises textuais permitiram a construção de três categorias temáticas: aspectos subjetivos da esfera emocional; subjetividades advindas do mundo social; aspectos subjetivos inerentes à autopercepção do paciente. Considerações finais: os aspectos subjetivos integram o processo de saúde e adoecimento do sujeito com hipertensão arterial e diabetes mellitus e agem na forma como a enfermidade é compreendida pelo indivíduo e consequentemente na adoção de atitudes e comportamentos diante do tratamento. Estratégias de educação em saúde devem contemplar esses aspectos para maior humanização e efetividade das ações de promoção à saúde e prevenção de complicações das doenças.
Palavras-chave: Hipertensão Arterial; Diabetes Mellitus; Educação em Saúde; Enfermagem, Psicologia.
O papel do enfermeiro na prevenção do desmame precoce
Authors: Lima Júlia Amancio Soares , Silva Jannaína Sther Leite Godinho da , Souza Alessandra da Silva , Gomes Elisângela do Nascimento Fernandes , Silva Eliara Adelino da , Lima Thainá Oliveira
Published: April 2024

O leite materno é o principal e único alimento que deve haver na vida de um bebê até seus seis meses de vida, porém existem dificuldades que fazem com que haja conflitos para um aleitamento materno exclusivo de sucesso, resultando em um desmame precoce. O objetivo geral do estudo é compreender a importância do papel do enfermeiro frente à prevenção do desmame precoce. Trata-se de uma pesquisa descritiva-exploratória, realizada através de busca na literatura de pesquisas que guardam familiaridade com o problema em questão. É de extrema importância que o enfermeiro seja um agente de mudanças, capaz de fornecer suporte não apenas para questões relacionadas às mamas, mas também para oferecer apoio emocional. Isso é essencial para auxiliar no enfrentamento do medo e da ansiedade que podem estar presentes e prejudicar esse período de amamentação. Além de fornecer orientações técnicas, o enfermeiro deve estar preparado para ouvir as preocupações e sentimentos das mães, proporcionando um ambiente acolhedor e de confiança. Ao abordar tanto as necessidades físicas quanto emocionais das mães, o enfermeiro desempenha um papel fundamental no apoio integral durante o processo de amamentação. Percebe-se que o papel do enfermeiro é de grande importância na prevenção do desmame precoce, pois o mesmo tem a oportunidade de acompanhar a mulher desde o início da gestação, até após o nascimento, podendo proporcionar a oportunidade de uma lactação de sucesso.
Palavras-Chave: Enfermagem; Desmame Precoce; Aleitamento Materno.
Ensino de enfermagem relacionado à assistência de enfermagem às gestantes usuárias de álcool e drogas
Authors: Bittencourt Mariane Alves Correa , Ferreira Helen Campos
Published: April 2024

O uso, o abuso de álcool e outras drogas durante a gestação constitui um dos transtornos psiquiátricos mais frequentes na gestação. Os efeitos do uso de substâncias são extremamente nocivos à saúde materna e ao desenvolvimento fetal. Objetiva-se identificar o desenvolvimento de competências de acadêmicos de enfermagem relacionados à assistência às gestantes usuárias de álcool e outras drogas durante a formação acadêmica. Elaborar uma proposta de cuidados de enfermagem e habilidades profissionais necessárias para assistência de enfermagem às gestantes usuárias de álcool e outras drogas. Trata-se de um estudo descritivo, exploratório, de caráter qualitativo, realizado em um Centro de Atenção Psicossocial em Álcool e drogas (CAPS AD) do município de Nova Friburgo-RJ no qual cinco acadêmicos de enfermagem de uma determinada instituição de saúde foram entrevistados por meio do preenchimento de um questionário e seus depoimentos constituíram evidências temáticas. Assim, os resultados apontam que: a temática foi pouco explorada durante a graduação e de forma superficial. Os discentes, em seu período final de formação, não se sentem preparados para assistir essas gestantes. Conclui-se, evidencia-se a necessidade de enfatizar a temática nos ambientes acadêmicos, aprimorando competências que os profissionais de enfermagem necessitam desenvolver para atuar com este público específico.
Palavras-Chave: Ensino de enfermagem; Gestantes; Assistência de Enfermagem; Usuários de drogas; Transtornos Relacionados ao Uso de Substâncias.
A relação entre a apneia obstrutiva do sono e mudanças no estilo de vida.
Authors: Costa Silva Raphael , Conceição de Siqueira Emílio
Published: April 2024

A apneia obstrutiva do sono (AOS) é uma patologia de alta prevalência e impacto deletério na saúde em função disso é um distúrbio o qual vem sendo cada vez mais estudado. A AOS é caracterizada por colapsos repetidos das vias aéreas superiores durante o sono, trazendo à esfacelação do sono, hipóxia e outros problemas. A obesidade, a idade, os hábitos de vida destoantes e o sexo são fatores de risco para a AOS. O tratamento padrão é o uso de pressão positiva contínua nas vias aéreas (CPAP), porém mudanças no estilo de vida, como modificação na dieta, exercícios e perda de peso, também são recomendadas. Foi realizada uma busca por trabalhos prévios nas bases de dados PubMed e Portal Regional da BVS e um total de 17 artigos científicos foram incluídos após a aplicação de critérios de inclusão e exclusão. Através das análises dos estudos foi visto que grande parte disserta a favor da mudança no estilo de vida e redução de peso evidenciando que são favoráveis na melhora da AOS, reduzindo a gravidade da doença e melhorando a qualidade de vida, outros artigos divulgam a importância da inclusão da tecnologia na busca por tal causa de se beneficiar na melhora da patologia e por fim há alguns pontos que abordam o tempo nesse quesito de tratamento. Visto isso, é fundamental que possamos fornecer e saber a devida importância das alterações na maneira de viver sobre a patologia AOS, redução de peso, exercícios físicos e outras medidas saudáveis são impactantes.
Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic
Insights
Authors: Soleimani Atena , Saeedi Nikoo , Al-Asady Abdulridha Mohammed , Nazari Elnaz , Hanaie Reyhane , Khazaei Majid , Ghorbani Elnaz , Akbarzade Hamed , Ryzhikov Mikhail , Avan Amir , Mehr Seyed Mahdi Hasanian
Published: April 2024

Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells
(CSCs) increase the probability of tumor development. These cells are identified by using CSC markers,
which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs
as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present
review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133,
and CD44, which offers a targeted and comprehensive analysis of their functions. The selection criteria for these
markersCancer were based on their established significance in Colorectal Cancer (CRC) pathogenesis and
clinical outcomes, providing novel insights into the CSC biology of CRC. Through this approach, we aim to elevate
understanding and stimulate further research for developing effective diagnostic and therapeutic strategies
in CRC.
Comprehensive Insights into Pathophysiology of Alzheimer's Disease:
Herbal Approaches for Mitigating Neurodegeneration
Authors: Sen Debasis , Rathee Sunny , Pandey Vishal , K. Jain Sanjay , K. Patil Umesh
Published: April 2024

Alzheimer's disease [AD] is a progressive neurodegenerative disorder characterized by
cognitive decline, memory loss, and functional impairment. Despite extensive research, the exact
etiology remains elusive. This review explores the multifaceted pathophysiology of AD, focusing
on key hypotheses such as the cholinergic hypothesis, hyperphosphorylated Tau Protein and Amyloid
β hypothesis, oxidative stress hypothesis, and the metal ion hypothesis. Understanding these
mechanisms is crucial for developing effective therapeutic strategies. Current treatment options
for AD have limitations, prompting the exploration of alternative approaches, including herbal interventions.
Cholinesterase inhibitors, targeting the cholinergic hypothesis, have shown modest efficacy
in managing symptoms. Blocking Amyloid β [Aβ] and targeting hyperphosphorylated tau
protein are under investigation, with limited success in clinical trials. Oxidative stress, implicated
in AD pathology, has led to the investigation of antioxidants. Natural products, such as Punica
granatum Linn, Radix Scutellariae, and Curcuma longa have demonstrated antioxidant properties,
along with anti-inflammatory effects, offering potential neuroprotective benefits. Several herbal
extracts, including Ginkgo biloba, Bacopa monnieri, and Withania somnifera, have shown
promise in preclinical studies. Compounds like Huperzine A, Melatonin, and Bryostatin exhibit
neuroprotective effects through various mechanisms, including cholinergic modulation and anti-inflammatory
properties. However, the use of herbal drugs for AD management faces limitations, including
standardization issues, variable bioavailability, and potential interactions with conventional
medications. Additionally, the efficacy and safety of many herbal products remain to be established
through rigorous clinical trials. This review also highlights promising natural products currently
in clinical trials, such as Resveratrol and Homotaurine, and their potential impact on AD
progression. DHA, an omega-3 fatty acid, has shown cognitive benefits, while Nicotine is being
explored for its neuroprotective effects. In conclusion, a comprehensive understanding of the complex
pathophysiology of AD and the exploration of herbal interventions offer a holistic approach
to managing this devastating disease. Future research should address the limitations associated
with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.
An Overview of Recent Analytical Techniques for Air Quality Monitoring
and Assessment
Authors: Mohammed Sa’adatu Eri , Badamasi Hamza , Unimke Augustine A. , Durumin Iya Naseer Inuwa , Olubunmi Aderibigbe Deborah , Okoro Chinyere , Okezie Onyemaechi , Olaleye Abdul Ademola
Published: April 2024

Access to clean air, a vital necessity for life, faces severe constraints globally due to industrialization and urbanization, leading to widespread air quality deterioration. To safeguard human
health and the environment from detrimental effects, the essential components of proper monitoring,
assessment, and management of air quality are paramount. Conventional air quality analytical techniques such as gas chromatography/ mass spectrometry, selected ion flow tube mass spectrometry,
thermal desorption/ gas chromatography, and mass spectrometry are widely used for air quality analysis. These methods, however, are laborious, necessitate sample preparation, require expansive and
hazardous reagents, and have a high cost of equipment and maintenance. As such, more rapid, sensitive, specific, cost-effective, portable, user-friendly, and environmentally friendly analytical tools are
required for efficient air quality monitoring and control. Over the years, various techniques have
emerged to address these challenges, including mobile sensors, microbial monitoring, the Internet of
Things (IoT), biomonitoring, and bio- and nanosensors in both indoor and outdoor settings. This
paper offers an overview of recent advancements in air quality monitoring and assessment methods.
The review encompasses sample preparations for air pollutants, data analysis methodologies, and
monitoring strategies. It also delves into the crucial role of microorganisms in air quality analysis.
Additionally, the paper explores the applications of the Internet of Things (IoT) and biosensors in air
quality monitoring and assessment, elucidating their roles in advancing these endeavors. The paper
concludes by presenting insightful perspectives on the current state of air quality monitoring techniques and outlining future directions for research and development in this critical field.
Primary Pulmonary Lymphoepithelioma-like Carcinoma: A Case Report Utilizing
Camrelizumab and Anlotinib for Prolonged Survival
Authors: Lei ShuangYi , Tian ShanShan , Lu SongMei , Qing Zhou , Long JianLin , Li LuChun , Yang Dan
Published: April 2024

Background:

Primary Pulmonary Lymphoepithelioma-like Carcinoma (PPLELC) is a rare form of
cancer for which no standard treatment has been established to date. Patients with advanced-stage PPLELC generally
have a poor prognosis with overall survival of 22.7 months.

Case Presentation:

Here, we report a case of advanced primary pulmonary lymphoepithelioma-like carcinoma.
Initially, the patient underwent a first-line (GP) and a second-line (DP) of chemotherapy, which provided temporary
relief but resulted in varying degrees of myelosuppression. When the disease progressed again, we administered
a third-line treatment consisting of camrelizumab combined with anlotinib.

Result:

This resulted in a progression-free survival of over 26 months without significant toxic side effects.

Conclusion:

Our findings suggest that combining camrelizumab and anlotinib could lead to a long progressionfree
survival in patients with advanced PPLELC.
Lactic Acid Bacteria As Biological Control Agent For Controlling Aspergillus Growth and Aflatoxin Production: A Review
Authors: Ahuja Rubi , Khan Minhaj Ahmad
Published: April 2024

:

Aspergillus sp., a ubiquitous filamentous fungus, poses significant challenges to the food industry
as a common spoilage and mycotoxin producing organism. The conventional use of chemical preservatives
to control Aspergillus contamination raises concerns about potential health risks and environmental impacts.
Therefore, alternative approaches, such as the utilization of natural biopreservatives, as inexpensive, safe,
and promising mycotoxin decontamination strategies are being explored. Lactic acid bacteria have gained
considerable attention as potential candidates due to their antimicrobial properties and long-standing safe use
in food fermentation. This review provides a thorough summary of the potential of lactic acid bacteria as
biopreservatives against Aspergillus sp. The inhibitory mechanisms of lactic acid bacteria against the proliferation
of Aspergillus and mycotoxin yield are explored, highlighting the role of organic acids, antimicrobial
peptides, and other bioactive compounds. The versatile application of lactic acid bacteria based natural preservatives
across a range of food matrices, storage conditions, etc. is also addressed. Further research is warranted
to optimize lactic acid bacteria strains, explore synergistic combinations, and investigate their efficacy
in real food systems. Implementing lactic acid bacteria based biopreservative strategies could significantly
enhance food safety and quality by reducing Aspergillus contamination and mycotoxin risks.
Effect of Chitosan-Beeswax Edible Coating on Microbiological Profile of Chicken Thigh Meat at Freezer Storage
Authors: Salwa Haneefah Fauzia  , Dedi Fardiaz  , Laprianika Retha Hapita Sari  , Dewi Masyithoh
Published: April 2024

This research examined the effect of chitosan and beeswax edible coating with different percentages on the microbiological value (aerobic bacteria, Staphylococcus aureus, Coliform, and Escherichia coli) of chicken thigh meat in two days of storage at freezer temperature (-18oC to -20oC). The study used Completely Randomized Design with 4 treatments and 5 replications. Treatments included were A0 (control), A1 (chitosan 2%), A2 (chitosan 2% + beeswax 1%), and A3 (chitosan 2% + beeswax 2%). Variables observed were the number of aerobic bacteria, S. aureus, Coliform, and E. coli using 3MTM PetrifilmTM Plates. Results showed significant differences (p<0.05) in the number of aerobic bacteria colonies with the least colony on treatment A1. S. aureus and Coliform colonies showed significant differences (p<0.05) with the least colony on treatment A2 and A3, sequentially. There was no significant difference (p>0.05) in E. coli count due to no colonies detected on all treated samples. However, compared to controlled samples, it was found to decrease. The decrease in colony numbers shows that edible coating treatments can be used to help preserve or extend the shelf life of chicken thigh meat.
Análisis de la implementación de cárceles agrícolas de la Zona 8 del Ecuador, un aporte a la inlclusión y sostenibilidad
Authors: Sotomayor Peralta Melany , Tigrero Romero Andrea , Marriott Zurita Gustavo
Published: April 2024

Los resultados que se exponen proceden de la investigación desarrollada con el objetivo de analizar la alternativa de implementación de cárceles agrícolas en atención a la rehabilitación social de los sancionados con pena privativa de libertad hasta cinco años en los establecimientos penitenciarios de la zona 8 de Ecuador. Asumido el enfoque cuantitativo con alcances descriptivo y explicativo, con el uso del método inductivo-deductivo y sistémico se establecieron las regularidades jurídicas. El estudio documental, la encuesta y la entrevista, con la aplicación de métodos matemáticos, posibilitó la corroboración sobre las insuficiencias de la rehabilitación en el sistema carcelario. Se obtuvieron criterios desfavorables de las condiciones de los establecimientos penitenciarios de la zona y de la atención por parte del Estado. La experiencia de los abogados participantes, confirma la importancia de actividades productivas para la rehabilitación y autovaloración del sancionado de hasta cinco años de privación de libertad con vistas a su reincorporación social y recomiendan la implementación de  cárceles agrícolas para los sancionados por delitos de menor trascendencia, en cumplimiento de lo refrendado por la Constitución de la República, siendo esencial, la garantía presupuestaria; el mejoramiento de la seguridad carcelaria; y, la capacitación de los funcionarios del sistema.
A Random Forest Algorithm for Assessing Risk Factors Associated With Chronic Kidney Disease: Observational Study
Authors: Liu Pei , Liu Yijun , Liu Hao , Xiong Linping , Mei Changlin , Yuan Lei
Published: April 2024

Background

The prevalence and mortality rate of chronic kidney disease (CKD) are increasing year by year, and it has become a global public health issue. The economic burden caused by CKD is increasing at a rate of 1% per year. CKD is highly prevalent and its treatment cost is high but unfortunately remains unknown. Therefore, early detection and intervention are vital means to mitigate the treatment burden on patients and decrease disease progression.

Objective

In this study, we investigated the advantages of using the random forest (RF) algorithm for assessing risk factors associated with CKD.

Methods

We included 40,686 people with complete screening records who underwent screening between January 1, 2015, and December 22, 2020, in Jing’an District, Shanghai, China. We grouped the participants into those with and those without CKD by staging based on the glomerular filtration rate staging and grouping based on albuminuria. Using a logistic regression model, we determined the relationship between CKD and risk factors. The RF machine learning algorithm was used to score the predictive variables and rank them based on their importance to construct a prediction model.

Results

The logistic regression model revealed that gender, older age, obesity, abnormal index estimated glomerular filtration rate, retirement status, and participation in urban employee medical insurance were significantly associated with the risk of CKD. On RF algorithm–based screening, the top 4 factors influencing CKD were age, albuminuria, working status, and urinary albumin-creatinine ratio. The RF model predicted an area under the receiver operating characteristic curve of 93.15%.

Conclusions

Our findings reveal that the RF algorithm has significant predictive value for assessing risk factors associated with CKD and allows the screening of individuals with risk factors. This has crucial implications for early intervention and prevention of CKD.
Assessing Differences in mHealth Usability and App Experiences Among Young African American Women: Secondary Analysis of a Randomized Controlled Trial
Authors: Opper Claudia A , Browne Felicia A , Howard Brittni N , Zule William A , Wechsberg Wendee M
Published: April 2024

Background

In North Carolina, HIV continues to disproportionately affect young African American women. Although mobile health (mHealth) technology appears to be a tool capable of making public health information more accessible for key populations, previous technology use and social determinants may impact users’ mHealth experiences.

Objective

The objective of this study was to evaluate mHealth usability, assessing differences based on previous technology use and social determinants among a sample of African American women in emerging adulthood.

Methods

As part of a National Institute on Drug Abuse–funded randomized controlled trial with African American women (aged 18-25 years), counties were assigned to receive an evidence-based HIV risk reduction intervention through mHealth and participants were asked to complete usability surveys at 6- and 12-month follow-ups. Participants’ first survey responses were analyzed through 2-tailed t tests and linear regression models to examine associations with previous technology use and social determinants (P<.05).

Results

The mean System Usability Scale (SUS) score was 69.2 (SD 17.9; n=159), which was higher than the threshold of acceptability (68.0). Participants who had previously used a tablet indicated higher usability compared to participants without previous use (mean 72.9, SD 18.1 vs mean 57.6, SD 11.4; P<.001), and participants with previous smartphone use also reported higher usability compared to participants without previous use (mean 71.9, SD 18.3 vs mean 58.0, SD 10.7; P<.001). Differences in SUS scores were observed among those reporting homelessness (mean 58.3, SD 19.0 vs mean 70.8, SD 17.2; P=.01), unemployment (mean 65.9, SD 17.2 vs mean 71.6, SD 18.1; P=.04), or current school enrollment (mean 73.2, SD 18.5 vs mean 65.4, SD 16.5; P=.006). Statistically significant associations were not observed for food insecurity (mean 67.3, SD 18.6 vs mean 69.9, SD 17.7; P=.45).

Conclusions

Although above-average usability was observed overall, these findings demonstrate differences in mHealth usability based on past and current life experiences. As mHealth interventions become more prevalent, these findings may have important implications for ensuring that mHealth apps improve the reach of evidence-based interventions.

Trial Registration

ClinicalTrials.gov NCT02965014; https://clinicaltrials.gov/study/NCT02965014

International Registered Report Identifier (IRRID)

RR2-10.1186/s12889-018-5796-8
Assessing Differences in mHealth Usability and App Experiences Among Young African American Women: Secondary Analysis of a Randomized Controlled Trial (Preprint)
Authors: Opper Claudia A , Browne Felicia A , Howard Brittni N , Zule William A , Wechsberg Wendee M
Published: April 2024

BACKGROUND

In North Carolina, HIV continues to disproportionately affect young African American women. Although mobile health (mHealth) technology appears to be a tool capable of making public health information more accessible for key populations, previous technology use and social determinants may impact users’ mHealth experiences.

OBJECTIVE

The objective of this study was to evaluate mHealth usability, assessing differences based on previous technology use and social determinants among a sample of African American women in emerging adulthood.

METHODS

As part of a National Institute on Drug Abuse–funded randomized controlled trial with African American women (aged 18-25 years), counties were assigned to receive an evidence-based HIV risk reduction intervention through mHealth and participants were asked to complete usability surveys at 6- and 12-month follow-ups. Participants’ first survey responses were analyzed through 2-tailed t tests and linear regression models to examine associations with previous technology use and social determinants (P<.05).

RESULTS

The mean System Usability Scale (SUS) score was 69.2 (SD 17.9; n=159), which was higher than the threshold of acceptability (68.0). Participants who had previously used a tablet indicated higher usability compared to participants without previous use (mean 72.9, SD 18.1 vs mean 57.6, SD 11.4; P<.001), and participants with previous smartphone use also reported higher usability compared to participants without previous use (mean 71.9, SD 18.3 vs mean 58.0, SD 10.7; P<.001). Differences in SUS scores were observed among those reporting homelessness (mean 58.3, SD 19.0 vs mean 70.8, SD 17.2; P=.01), unemployment (mean 65.9, SD 17.2 vs mean 71.6, SD 18.1; P=.04), or current school enrollment (mean 73.2, SD 18.5 vs mean 65.4, SD 16.5; P=.006). Statistically significant associations were not observed for food insecurity (mean 67.3, SD 18.6 vs mean 69.9, SD 17.7; P=.45).

CONCLUSIONS

Although above-average usability was observed overall, these findings demonstrate differences in mHealth usability based on past and current life experiences. As mHealth interventions become more prevalent, these findings may have important implications for ensuring that mHealth apps improve the reach of evidence-based interventions.

CLINICALTRIAL

ClinicalTrials.gov NCT02965014; https://clinicaltrials.gov/study/NCT02965014

INTERNATIONAL REGISTERED REPORT

RR2-10.1186/s12889-018-5796-8
LASSO Based Analysis for Prediction of Prognostic Signature Genes Associated with Breast Cancer (Preprint)
Authors: Guha Souvik
Published: April 2024

BACKGROUND

Cancer is a genetic disease, where gene alterations play a significant role in the disease onset and pathogenesis. Analysis of the underlying gene interaction pathways could reveal new biomarkers and could also potentially help in the development of targeted drugs for therapeutics. Microarray techniques have emerged as powerful tools capable of simultaneously measuring the expression levels of thousands of genes, making them invaluable in cancer biology research. However, the processing of the resultant datasets poses significant challenges due to their high dimensionality. Also, feature extraction becomes essential to discern the crucial features within these extensive datasets.

OBJECTIVE

To mitigate these difficulties advanced computational techniques like Machine Learning (ML) could be instrumental. LASSO- regression-based classification is an advanced ML technique that can help in feature selection by evaluating individual parameters like genes.

METHODS

This study focuses on uncovering key prognostic genes for breast cancer using a combination of LASSO regression-based classifier and statistical bioinformatics models. Differentially expressed genes (DEGs) were identified using the "Limma" package in R, and significant genes were further filtered using the LASSO-based classifier significance coefficient. Genes common to both methods were considered as the focus of this study. Additionally, Protein-Protein Interaction (PPI) networks of these key genes were constructed using STRING, and hub genes, significant modules, and associated genes were identified using Cytoscape.

RESULTS

This study identified CCR8, CXCL11, CCL23, CCL24, CCL28, and CCL21 as signature prognostic genes for breast cancer, revealing a strong association between chemokines and breast cancer pathogenesis. Extensive literature searches were conducted to validate and confirm their prognostic significance in the disease.

CONCLUSIONS

These findings are pivotal for enhancing our comprehension of the pathways involved in breast cancer. Additionally, they hold promise as novel biomarkers for diagnostic purposes and may also reveal significant therapeutic targets for the management of breast cancer.
Induced Resistance of Shallot (Allium cepa L. var aggregatum) against Twisted Disease Using Ultraviolet-B Light
Authors: Ahmad Yan Syahrial , Wibowo Arif , Widiastuti Ani
Published: April 2024

Ultraviolet-B (UV-B) light is known to induce plant resistance in suppressing disease infection. Its ability to induce plant resistance has been widely used as an inducer of plant resistance. This study aims to determine the ability of UV-B light in suppressing shallot twisted disease, potency of plant resistance induction through accumulation of peroxidase enzymes, salicylic acid, chlorophyl content and to observe shallot growth after treatment. This study applied UV-B light with a duration of 65 mW/m2 for 4 hours each day for 3, 5 and 7 days, for inoculated and non-inoculated plants. Fungicide (Benomyl) was used as a comparison for inoculated plants. The results showed that UV-B irradiation of 4 hours/day for 7 days was able to reduce the incidence of shallot twisted disease, but the incubation period among treatments was not significantly different. UV-B irradiation of 4 hours/day, for 7 days was able to increase salicylic acid content, and maintain the same chlorophyll content as the negative control, however the peroxidase enzyme content was not significantly different. Treatment of UV-B 4 hours/day for 7 days irradiation did not inhibit the growth and production of shallot plants.
Utilization of Arbuscular Mycorrhizal Fungi and Bacillus velezensis Inoculation in Suppressing Twisted Disease of Shallot
Authors: Abdullah Jilan Tsani , Suryanti Suryanti , Joko Tri
Published: April 2024

Twisted disease is one of the problems in shallot cultivation. The application of the biological agents Bacillus velezensis and Arbuscular Mycorrhizal Fungi is an alternative expected to overcome disease problems in shallot plantings. The purpose of this study was to determine the effect of the application of B. velezensis and Arbuscular Mycorrhizal Fungi on the growth and health of shallot. The research was conducted in Gotakan, Panjatan, Kulon Progo, and the Phytopathology Laboratory, Department of Plant Protection, Faculty of Agriculture, Universitas Gadjah Mada, Yogyakarta. Shallot treatments with the application of biological agents were carried out either individually by soaking the bulbs in B. velezensis suspension before planting, coating the bulbs using Arbuscular Mycorrhizal Fungus (Rhizophagus intraradices) with a carrier medium of kaolin flour before planting, and a combination of spraying the B. velezensis suspension on plants at two-week intervals during the growth period and coating the bulbs before planting with R. intraradices. The results of the study showed that the shallot-applied single application of B. velezensis reduced the intensity and incidence of twisted disease by 2.51% and 37.6%, respectively. The combination treatment of B. velezensis and R. intraradices was able to increase the resistance of bulbs to postharvest pathogen Fusarium solani infection, with infected bulbs and areas of 0.70% and 0.71%, respectively.
An Ecolinguistic Perspective Study on Linguistic Resources Emotions of Migrants in Huizhou
Authors: Cai Yuxuan
Published: April 2024

Mobility has received burgeoning attention in social science studies, and it is of great significance to the academic research to migrants’ dialects in China. Most research shows that individuals have a strong emotional attachment to their first language. However, in this study, from the perspective of ecology, semi-structured interviews were used to explore the experience and emotional attitudes of immigrants living in Huizhou city, Guangdong Province. Although immigrants take their native language as a symbol of their early life memories, other languages could also be a suitable medium for showing their inner world when they move to a new place and use another language. People’s positive or negative emotions towards their first or second languages depend on how they interact with their surroundings. Based on the results, this paper provides a deeper understanding of adult migrants’ language choices from an ecolinguistic perspective.
Research on the Development Strategy of Red Study Tourism in Ganzi Prefecture
Authors: Xie Wei
Published: April 2024

The study found that Ganzi Prefecture is rich in red historical sites and cultural symbols, but faces multiple challenges in its development, such as insufficient policy support, problems with tourists’ experience, and difficulties in cultural inheritance. By strengthening policy guidance, improving product quality, promoting the integration of industry and education, as well as focusing on cultural inheritance and innovation. At the same time, it focuses on environmental protection and social participation in the development process to ensure the sustainability of red study tours, promote the combination of red study tours and cultural inheritance, and realize the win-win situation of economic benefits of tourism and cultural heritage, which is of positive significance for promoting the development of local society and economy, as well as protecting and inheriting the red culture.
Assessment of completed BRIDGE Discovery projects Synthesis at programme level
Authors:   KMU Forschung Austria, Kaufmann Joachim , Kaufmann Peter , Grabner Simone Maria
Published: April 2024

The aim of this short evaluation was to systematically collect information from the completed projects of the BRIDGE Discovery programme as of June 2023. This will be used for strategic optimisation and decision making for the funding period 2025-2028. BRIDGE Discovery is an open-topic funding programme at the interface between basic and applied research, which is jointly funded and implemented by the Swiss National Science Foundation (SNSF) and Innosuisse - Swiss Agency for Innovation Promotion. The study used a mixed-methods approach to gather information about the programme context and the funded projects: analyses of programme documents; interviews with programme managers, members of the steering committee, the evaluation panel, etc.; analyses of project data and reports; interviews with principal investigators and implementation partners; and an online survey. The results of the study indicate a rather large gap between the portfolios of the SNSF and Innosuisse, resulting in a high demand for BRIDGE Discovery. Given the current budget constraints, options for a more comprehensive picture of portfolio integration are outlined.