bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Operative Intervention Volume on the State of the Vagina Microbiocenosis in Women with Uterine Leiomyoma
Authors: Маланчук Л.М. , Мартынюк В.Н. , Маланчин И.Н. , Кучма З.Н. , Маланчук С.Л.
Published: April 2022

Работа посвящена оценке и сравнительному анализу микробиоценоза генитального тракта у женщин, которым выполнялась экстирпация матки с и без овариоэктомии. Установлено, что двусторонняя овариоэктомия приводит к формированию хирургической менопаузы и нарушений в микроэкосистеме влагалища в сторону элиминации лактофлоры и развития патогенной и условно-патогенной микрофлоры. На основании проведенного клинико-лабораторного обследования, которое дополнялось результатами бактериоскопического и бактериологического исследования влагалищных мазков, определены закономерности патогенетического течения бактериального вагиноза у женщин, перенесших оперативные вмешательства на яичниках.

This scientific work is devoted to the estimation and comparative analysis of microbiocenosis of vagina in women, which had extirpation uteruses with and without additions. It is set that bilateral ovarioectomy results in forming of surgical menopause and violations in the microecosystem of vagina towards the elimination of lactoflora and development of pathogenic and conditionally- pathogenic microflora. On the basis of the conducted clinical and laboratory inspection that was complemented by the results of bacterioscopical and bacteriological examination of vaginal strokes, conformities to law of nosotropic motion of bacterial vaginosis are certain for women that carried operative interventions on additions.
Placental Disorders: Early Diagnosis and Preventive Correction
Authors: Гутикова Л.В. , Смолей Н.А. , Усков С.И.
Published: April 2022

Плацентарные нарушения осложняют до 60 беременностей и являются одной из причин перинатальной заболеваемости и смертности. Поиск этиопатогенетических механизмов развития плацентарных нарушений лежит в основе разработки разных способов лечения данного осложнения гестации. Важное значение в поддержании нормального маточно-плацентарного кровотока при физиологической беременности имеет базальная секреция оксида азота эндотелием сосудов в кровоток. В то же время метод исследования функции эндотелия как один из способов диагностики и прогнозирования развития плацентарных нарушений до настоящего времени не использовался. Отсутствие данных о взаимосвязи нарушения кровообращения в системе мать плацента плод и нарушения вазорегулирующей функции эндотелия и легли в основу совершенствования ранней диагностики и превентивной коррекции плацентарных нарушений. Разработанный нами метод визуализации просвета плечевой артерии с помощью ультразвука высокого разрешения позволяет исследовать вазорегулирующую функцию эндотелия. При выявлении показателей чувствительности плечевой артерии и напряжения сдвига на эндотелии выше нормального значения обследованные беременные формируют группу риска по развитию плацентарных нарушений. Разработанная схема коррекции, включающая метаболическую терапию и комплекс физических упражнений, позволяет нормализовать показатели вазорегуляции сосудистой стенки и снизить вероятность развития плацентарных нарушений на 70.

Placental disorders complicate up to 60 of pregnancies and are one of the causes of perinatal morbidity and mortality. The search for etiopathogenetic mechanisms for the development of placental disorders underlies the development of different methods of treating this complication of gestation. The basal secretion of nitric oxide by the vascular endothelium into the bloodstream is important in maintaining normal utero-placental blood flow during physiological pregnancy. At the same time, the method of studying endothelial function as one of the methods for diagnosing and predicting the development of placental disorders has not yet been used. The lack of data on the relationship between endothelial vasoregulatory dysfunction and circulatory dysfunction in the mother-placenta-fetus system formed the basis for improving early diagnosis and preventive correction of placental disorders. Our method of visualization of the brachial artery lumen using high-resolution ultrasound allows to study the vasoregulatory function of the endothelium. When the brachial artery sensitivity and endothelial shear stress are detected above the normal value, the examined pregnant women form a risk group for the development of placental disorders. The developed correction scheme, including metabolic therapy and a set of physical exercises, allows normalizing the parameters of vasoregulation of the vascular wall and reducing the likelihood of placental abnormalities by 70.
Clinical and Diagnostic Principles of Pregnancy Follow-up with Diffuse Endemic Goiter
Authors: Смолей Н.А.
Published: April 2022

Течение беременности у женщин с диффузным эндемическим зобом характеризуется высокой частотой осложнений. При этом плацентарные нарушения возникают в 53,34 случаев, преждевременные роды наблюдаются в 13,33 случаев, оперативное родоразрешение в экстренном порядке в 30,0 случаев. Диагностируются также и нарушения психологического статуса, наиболее частым из которых является субклинически выраженная тревога (55,72 случаев). При сочетании патологии щитовидной железы и преэклампсии течение беременности усугубляется, а частота рождения здорового ребенка снижается до 9,4. Патогенетические механизмы нарушения течения гестационного процесса при диффузном эндемическом зобе и преэклампсии обусловлены характером гормональных и метаболических изменений в организме женщины. Нарушение функции щитовидной железы приводит к дезорганизации работы прооксидантной системы и повышению концентрации продуктов перекисного окисления липидов. Разработанные методы коррекции диффузного эндемического зоба при беременности в сочетании с преэклампсией позволяют нормализовать функциональное состояние тиреоидной системы. Восстановление гормонального баланса приводит к снижению частоты акушерских осложнений. Слабость родовой деятельности, равно как и острая, и хроническая внутриматочная гипоксия плода, диагностируется в 6,7 раза реже по сравнению с таковыми в подгруппе пациентов, получавших традиционную терапию. При этом частота рождения здорового ребенка повышается в 4 раза у женщин с диффузным зобом и в 6,47 раза при его сочетании с преэклампсией.

The course of pregnancy in women with diffuse endemic goiter is characterized by a high frequency of complications. In this case, placental disorders occur in 53.34 of cases, premature birth is observed in 13.33 of cases, operative delivery in an emergency order in 30.0 of cases. Psychological status disorders are also diagnosed, the most frequent of which is asymptomatic expressed anxiety (55.72 of cases). In combination with thyroid pathology and preeclampsia, the course of pregnancy is aggravated, and the birth rate of a healthy child is reduced to 9.4. Pathogenetic mechanisms of gestational process disorders in diffuse goiter and preeclampsia are due to the nature of hormonal and metabolic changes in the female body. Violation of thyroid function leads to disorganization of the pro-oxidant system and increase the concentration of lipid peroxidation products. The developed methods of correction of diffuse endemic goiter during pregnancy in combination with preeclampsia allow to normalize the functional state of the thyroid system. Restoration of hormonal balance leads to a decrease in the frequency of obstetric complications. Violations of labor activity, as well as acute and chronic intrauterine fetal hypoxia are diagnosed 6.7 times less frequently compared to those in the subgroup of patients receiving conventional therapy. At the same time, the rate of birth of a healthy child increases 4 times in women with diffuse goiter and 6.47 times in combination with preeclampsia.
Evaluation of Ultrasound Endometrial Receptivity Markers to Predict Outcomes of Assisted Reproductive Technology Programs (Literature Review)
Authors: Турок И.В. , Улезко Е.А.
Published: April 2022

Обзор литературы посвящен возможностям ультразвуковой диагностики (УЗД) в предикции исходов программ вспомогательных репродуктивных технологий (ВРТ). В качестве ультразвуковых маркеров (УЗМ) рецептивности эндометрия (РЭ) на сегодняшний день используются толщина и структура эндометрия, состояние переходной зоны, оценка маточного кровотока и перистальтика эндометрия. В статье представлен анализ литературных данных о современных взглядах на возможности использования УЗМ РЭ в практической деятельности с целью повышения эффективности методов ВРТ.

A review of the literature is dedicated to the possibilities of ultrasound diagnostics in predicting the outcome of assisted reproductive technology programs. Today, the thickness and pattern of the endometrium, evaluation of the transition zone, the assessment of uterine blood flow and endometrial peristalsis are used as ultrasound markers of endometrial receptivity. The article presents an analysis of literary data on modern views on the possibility of using ultrasound in practice in order to increase the effectiveness of ART methods.
"My smartphone is Following Me": Medical and Psychological Discourse of using Mobile Communication Devices. Part 2
Authors: Николаев Е.Л. , Кулыгина М.А.
Published: April 2022

Интенсивное использование смартфонов сопровождается появлением новых психосоциальных феноменов, негативно влияющих на здоровье и благополучие человека. Описывается целый ряд таких состояний. Выраженные проявления синдромов фантомной вибрации и фантомного звонка связаны с клиническими признаками тревоги и депрессии. Номофобия (страх остаться без мобильного устройства или без контакта с ним) рассматривается как манифестация формирующегося тревожного расстройства или зависимого от смартфона поведения. Селфитис (навязчивое стремление фотографировать самого себя и размещать снимки в социальных сетях) ведет к нарушениям в эмоциональной сфере и искажениям самовосприятия, что, в свою очередь, чревато высоким риском травм и смертельных случаев. Кибербуллинг как явление намеренно повторяющегося причинения вреда человеку посредством общения в виртуальной среде представляет явную опасность для молодого поколения, в том числе из-за высокого риска суицидальности. В заключении даны профилактические рекомендации по снижению возможного вреда от негативных воздействий современных средств мобильной связи на физическое и психическое здоровье и благополучие пользователя.

Heavy use of smartphones is accompanied by the list of new psychosocial phenomena that are unfavorably associated with a person’s health and well-being. the whole spectrum of such conditions is presented here. Expressed manifestations of phantom ringing and phantom vibration syndromes, which are sensory or auditory hallucinations of sensing or hearing a phone signal when there is really none, are associated with the clinical symptoms of anxiety and depression. Nomophobia (fear of staying without a mobile device or without access to it) is regarded as the manifestation of the growing anxiety disorder or the addictive smartphone behavior. apart from being harmful to health, the behavior of those dependent on smartphone or social networks can have negative socialconsequences (decrease of working efficiency, risk of accidents). Selfitis is an obsessive urge to take photos of oneself and share them on social media, which leads to emotional disorders, depreciated self-attractiveness, high risk of injuries and fatalities. Cyberbullying, as a phenomenon of harming a person repeatedly by means of communication electronic devices, is obviously dangerous for the children’s health and well-being due to its association with suicidality. the conclusion gives prophylactic recommendations on reducing the harmful effects of modern mobile communication devices on mental health of their users.
Results of Separate Determination on General, Platelet and Free Serotonin in Blood Plasma of Primary Donors
Authors: Мулярчук О.В.
Published: April 2022

В статье изложены данные о физиологической роли серотонина. Представлены данные о содержании его уровня в плазме крови и тромбоцитах у 126 доноров в возрастеот 22 до 55 лет (73 мужчины и 53 женщины), которые осуществляли донацию крови впервые.Все доноры были обследованы в соответствии с требованиями Порядка медицинского обследования доноров крови и/или ее компонентов, утвержденного Приказом МЗ Украины от01.08.2005 г. № 385 «Об инфекционной безопасности донорской крови и ее компонентов»как доноры, кровь которых используется для изготовления компонентов. Перед донациейдонорам проводили анкетирование и медицинское освидетельствование квалифицированными специалистами в соответствии с требованиями действующего Порядка медицинского обследования доноров крови и/или ее компонентов. У каждого донора определяли содержание гемоглобина (норма: мужчины – не менее 130 г/л, женщины – не менее 120 г/л).Представлен метод фракционного определения серотонина в предварительно высушеннойпробе биосубстрата, осуществляемый путем экстракционных процедур при оптимальныхконтролируемых значениях рН, необходимых для выделения серотонина, образованияфлуорофоров соответственно ортофталевому альдегиду и нингидрину с последующейфлуориметрической оценкой его содержания на отечественном флуориметре «БИАН». Обсуждаются возможные патофизиологические механизмы влияния изученных факторов на метаболические процессы.

In the article, the data on physiological role of serotonin are stated. There are presented the dataon its level in blood plasma and platelets of 126 donors aged from 22 to 55 years (73 men and53 women), who carried out the first donation. All donors were examined according to the MedicalExamination Procedure for Donors of Blood and (or) its Components approved by the Decree ofthe Ministry of Health of Ukraine № 385 dated 01.08.2005 "On Infectious Safety of Donor Blood andits Components" as donors, whose blood is used for production of components. Before donation,blood donors filled in the questionnaire and were examined by qualified specialists according tothe requirements of the applicable Medical Examination Procedure for Donors of Blood and (or)its Components. Hemoglobin was measured in all the donors (RR: M – no less than 130 g/l, F –no less than 120 g/l). There was presented the method of fractional determination of biologicalamines – serotonin – in preliminarily dried biosubstrate sample. The described method includessome extraction procedures with optimal controlled pH values necessary for isolating serotonin,producing fluorophors in accordance with orthophtaldialdehide and ninhydrin, with the followingfluorimetric estimation of their levels performed on the domestic fluorimeter "BIAN". The possiblepathophysiological mechanisms of the influence of the studied parameters on metabolic processeswere discussed.
On the Issue of differential Diagnosis of Pseudosarcoma and Kaposi’s Sarcoma (Clinical Case)
Authors: Алиев А.Ш. , Мухамедов Б.И. , Колдарова Э.В.
Published: April 2022

В статье представлены литературные данные по саркоме Капоши: описаны основные формы, клинические проявления, трудности и алгоритм диагностики. Подробно освещены критерии дифференциального диагноза саркомы и псевдосаркомы Капоши. Представлен клинический случай развития псевдосаркомы Капоши типа Мали у пациента 74 лет.

The article presents the literature review on Kaposi’s sarcoma – the main forms, clinical manifestations, difficulties and diagnostic algorithm are described. Criteria for differential diagnosis of Kaposi’s sarcoma and pseudosarcoma are covered in detail. The paper presents the clinical case of Pseudosarcoma Kaposi Mali type of patient at age of 74 years.
Audiovisual Quality Control and Preservation Case Studies from Libraries, Archives, and Museums
Authors: Kim Julia , Colloton Eddy , Finn Dan , Fraimow Rebecca , Lin Shu-Wen , Sanchez Crystal , Schweikert Annie
Published: April 2022

Digital audiovisual workflows are complex. They can hinge on a breadth and depth of knowledge that is difficult to find within a single team or institution. The areas of knowledge called on can range from obscure and obsolete audiovisual carriers, to all the components in a digitization workflow chain, as well as new and evolving community resources and digital competencies for discovering errors during the quality control process. While there are many standardized audiovisual workflows, as this paper illustrates, QC work can be difficult even with a high level of training and experience; and problems, when caught, are often resource-intensive to diagnose and address. This paper details six distinct audiovisual case studies in which different digital preservation obstacles that are difficult to qualify, fully understand, and document are discussed; as well as, when possible, their solutions. They are all unique, but also unexceptional: we expect there are comparable situations, perhaps not-yet discovered or addressed in many audiovisual archives. This paper will underscore difficulties, and guide readers through some of the processes -- both formal and informal -- used to further analyze audiovisual file problems. Ultimately, in addition to helping other staff with similar problems, this paper should emphasize to administrators the special resource needs of audiovisual files and the staff responsible for them.
ISSUES AND CHALLENGES OF COVID-19 PANDEMIC ON TOURISM AND HOSPITALITY EDUCATION IN MALAYSIA: A PRELIMINARY STUDY OF THE EVENT
Authors: Mohd Shariff Nurhazani , Zainol Abidin Azlan
Published: April 2022

The COVID-19 pandemic has immobilized almost the entire world today. In fact, the COVID-19 pandemic has also incapacitated all aspects of world life including education, community, employment and many more. Tourism and hospitality is one of the industries which seriously affected amid COVID-19 pandemic. It is undeniable that education is highly impacted within the industry amid COVID-19 and affects the future graduates’ employability. This study investigates issues and challenges of Malaysian tourism and hospitality education amid COVID-19 pandemic. A semi-structured interview was conducted through telephone involving 11 tourism and hospitality educators to identify issues and challenges faced within the academic institutions amid COVID-19 pandemic. The number of respondents is considered appropriate for a preliminary study to understand the event before proceeding with further study. The respondents were asked three major questions; (i) issues faced amid COVID-19 pandemic, (ii) challenges and (iii) recommendations for further action in dealing with the issues and challenges. The findings revealed that the critical issues faced within tourism and hospitality education during the pandemic are impacts toward internships and delivery of teaching and learning. The COVID-19 pandemic also brings about challenges in terms of unemployment and requirement of new skills for graduates’ employability. Further, three skills are needed by the tourism and hospitality graduates amid COVID-19 namely technology skills, soft skills and entrepreneurial skills. In conclusion, the findings suggest the need to reform Malaysia tourism and hospitality education as digital education. This study is considered as a preliminary study involving only few educators to identify issues and challenges of tourism and hospitality education amid COVID-19 pandemic, hence the findings cannot be generalized to the whole academic institutions offering the courses. Future study is recommended to be undertaken using more number of respondents representing the academic institutions in Malaysia.
A REVIEW ON THE RESILIENCE MODELS AND ATTRIBUTES WITHIN THE BUILT ENVIRONMENT
Authors: Ali Ahmed Hamed , Mohamed Khaizdir Khairul Anwar , Mohd Rashid Aiman
Published: April 2022

Resilience is considered as the ability of systems to cope (or adapt) with adversity over time. However, there is an ongoing debate around the resilience paradigm, and similarly, most resilience descriptions are often application specific. This article reviews various resilience models in the built environment such as the representation of resiliency and its characteristics (e.g., sociocultural networks), objectives (e.g., enhancing knowledge systems), challenges (e.g., adaption), and applications (e.g., climate resiliency and disaster). This paper aims to establish a foundation for further investigation in built environment resilience. Open issues are drawn toward the end of this article to reveal new research avenues to shed light and spark new interest in this research field.
mudança da esfera pública brasileira na “Teoria do medalhão”, de Machado de Assis
Authors: Moraes Felipe Moralles e
Published: April 2022

A partir do conto “Teoria do medalhão”, enfrento três interpretações correntes sobre a obra machadiana – de uma obra que ironiza criticamente as relações baseadas na hierarquia, escravidão e troca de favores, como lê Roberto Schwarz, ou de uma obra que ironiza o ser humano cinicamente, assim Alfredo Bosi, ou tragicamente, assim Rogério de Almeida. Argumento que o conto retrata a função de ornamentação da esfera pública brasileira no momento importante da reconfiguração de uma sociedade rural e estratificada em uma urbana e massificada, como anunciava o movimento republicano. E que a ironia machadiana tem em vista o potencial transformador de uma esfera pública culta, racional e não ornamental, ainda que subalterna, presente na literatura.
Concentrations and diffusion coefficients of thermal equilibrium point defects in silicon crystals
Authors: Suezawa Masashi , Iijima Yoshiaki , Yonenaga Ichiro
Published: April 2022

The dependencies of concentrations of thermal equilibrium vacancies and interstitials on temperatures in Si crystals are determined directly, which has been a long-standing issue since the 1950s. They are evaluated by combining the formation energies and self-diffusion entropies deduced from the analyses of self-diffusion coefficients, and migration entropies deduced from diffusion coefficients of point defects. The concentrations as the number density of thermal equilibrium vacancies and interstitials at temperature T (K) are determined to be 5 × 1022exp(6.5)exp(–3.85 eV/k
B
T) and 5 × 1022exp(10.6)exp(–4.3 eV/k
B
T) cm−3, respectively. The diffusion coefficients of vacancies and interstitials are determined to be 2.7 × 10−3exp(–0.45 eV/k
B
T) and 2.5 × 10−2 exp(–0.49 eV/k
B
T) cm2 s−1, respectively. The results are discussed in comparison with those reported experimentally.
Characterization of interface properties of Al2O3/n-GaSb and Al2O3/InAs/n-GaSb metal-oxide-semiconductor structures
Authors: Yokoyama Masafumi , Yokoyama Haruki , Takenaka Mitsuru , Takagi Shinichi
Published: April 2022

The interfacial InAs layers can improve the metal-oxide-semiconductor (MOS) interface properties of n-type GaSb (n-GaSb) MOS capacitors (MOSCAPs) with Al2O3 insulating layers deposited by an ex situ atomic-layer deposition (ALD) process. The n-GaSb MOSCAPs show the capacitance response in the accumulation region at RT, but they did not show the response with any low frequency at 100 K, indicating the quite high interface trap density (D
it). On the contrary, the n-GaSb MOSCAPs with the interfacial InAs layers show sufficient accumulation responses at 100 K as well as RT, indicating the lower D
it. The 1.5 nm thick InAs/n-GaSb MOSCAP with ALD-Al2O3 deposited at 150 °C exhibited relatively low D
it of 2.6 × 1013 cm−2 eV−1, and the 2.5 nm thick InAs/n-GaSb MOSCAP with ALD-Al2O3 deposited at 300 °C exhibited low D
it of 2.6 × 1012 cm−2 eV−1, while the 2.5 nm thick InAs layers can induce the delay of the response of electrons with the high frequency measurements at low temperature.
Fabrication of reduced graphene oxide with high electrical conductivity by thermal-assisted photoreduction of electrochemically-exfoliated graphene oxide
Authors: Hirotomi Yuji , Kubota Wataru , Utsunomiya Toru , Ichii Takashi , Sugimura Hiroyuki
Published: April 2022

Electrochemical exfoliation of graphite is a method for synthesizing graphene oxide (GO) with fewer structural defects than GO synthesized by conventional chemical oxidation. Photoreduction of GO has been focused on due to their facile procedures, and environmental friendliness. In this report, electrochemically-exfoliated graphene oxide (EGO) was irradiated by vacuum ultraviolet (VUV) light at 140 °C under a high vacuum environment, named thermal-assisted VUV light treatment. Conductive atomic force microscopy was used to investigate the electrical characteristics of individual sheets on the nanometer scale. The electrical conductivity of the treated sheet (1.4 × 105 S m−1) was higher than the pristine EGO by an order of magnitude. The chemical and structural analysis showed that the EGO was reduced and their π-conjugated domains were restored through a hybrid of photochemical and thermal treatment. These results indicate that our hybrid approach has the potential for reducing the EGO.
Layer-resolved magnetic moments in N-surfactant assisted FeNi ordered alloy thin films
Authors: Kawaguchi K. , Miyamachi T. , Gozlinski T. , Iimori T. , Takahashi Y. , Hattori T. , Yamamoto K. , Koitaya T. , Iwayama H. , Ishiyama O. , Nakamura E. , Kotsugi M. , Wulfhekel W. , Yokoyama T. , Komori F.
Published: April 2022

We investigated structural and magnetic properties of FeNi ordered alloy thin films grown by nitrogen-surfactant assisted process using scanning tunneling microscopy and soft-X-ray absorption spectroscopy/magnetic circular dichroism. With the help of structurally controlled surface and interface by the N surfactant effect, the results successfully provide the layer-resolved spin magnetic moments of the Fe layer. Furthermore, the critical role of the topmost layer on the magnetic anisotropy is identified from a thickness dependence of the Fe orbital magnetic moment; the out-of-plane magnetization emerges when the Fe–N bonds, which favor the in-plane magnetization, break and the Ni–N bonds form in the NiN topmost layer.
İn Vitro Lipopolisakkarit Uyarımlı Karaciğer Yangı Modelinde Alfa-Terpineol’ün Etkinliğinin Araştırılması
Authors: TUNÇER Ayşe Pınar , KÜÇÜKGÜL Altuğ , İŞGÖR Mehmet Mustafa
Published: April 2022

Terpinoller monoterpen bileşikler olup, birçok çalışmada antioksidan özelliklerinden dolayı antikanser, antikonvülsant ve antiülser gibi biyolojik etkileri ortaya konulmuştur. Araştırmanın amacını, LPS’in karaciğer hücrelerine uygulanarak oluşturulan yangı modelinde, α-terpineol’ün antiinflamatuar ve antiapoptotik biyofonksiyonlarının araştırılması oluşturmuştur. Denemede insan orijinli HepG2 (ATCC® HB-8065) hücreleri materyal olarak seçilmiştir. LPS ve α-terpineol, hücrelere farklı konsantrasyonlarda 24 saat uygulanmıştır ve etkin konsantrasyonları, hücre canlılık testleriyle (MTT) gerçekleştirilmiştir. Sonrasında, TNF-α, IL-1β, IL-10, Kaspaz 3, Bax ve Bcl-2 gen ekspresyon düzeyleri tam zamanlı kantatif polimeraz zincir reaksiyonuyla (qRT-PCR) araştırılmıştır. LPS’in 50 ng/ml konsantrasyonu %11,5 oranında hücre kayıplarına neden olduğu belirlenmiş ve modelleme için bu konsantrasyon seçilmiştir. Ancak, 10 μM konsantrasyonda α-terpineolün hücre kayıplarını % 2.12 oranında önlediği bulunmuştur. Çalışmada, LPS’in TNF-α ve IL-1β gen ekspresyonlarını arttırdığı, α-terpineol uygulamasının ise bu durumu tersine çevirdiği tespit edilmiştir. Yine, IL-10 gen ekspresyonu yüksek LPS konsantrasyonu ile baskılanırken, α-terpineol tarafından anlamlı düzeyde uyarıldığı da ortaya konulmuştur. Bununla birlikte, LPS’in kaspaz 3 ve Bax gen ekspresyonlarını arttırdığı, ancak α-terpineol’ün bu stimülasyonu baskıladığı tespit edilmiştir. Bcl-2 gen ekspresyonları ise LPS tarafından baskılanırken, α-terpineol tarafından uyarıldığı bulunmuştur. Özetle, α-terpineol’ün kısa süreli ve düşük olan proliferatif konsantrasyonunun özellikle patojen kaynaklı karaciğer rahatsızlıklarında alternatif bir tedavi ajanı olabileceği görülmüştür.
DIVA (Differentiating Infected from Vaccinated Animals) Vaccines and Strategies
Authors: ERDEM Asena Esra , SAREYYÜPOĞLU Barış
Published: April 2022

In veterinary medicine, vaccination is one of the most effective techniques for control and prevention of diseases. When other methods fail in control of animal diseases, different vaccines and strategies are developed. DIVA (Differentiating Infected from Vaccinated Animals) vaccines lacking one or more antigenic epitope(s)/ protein(s) in the prevailing field strain and the accompanying diagnostic tests are effective in eradication and control of diseases. While currently used vaccines can not distinguish between vaccinated and infected animals, DIVA vaccines can be very useful for the purpose. Serological tests, such as ELISA (Enzyme-Linked ImmunoSorbent Assay), used together with DIVA vaccines, can be used to determine which animals are infected and which are vaccinated. DIVA vaccines and strategies for some animal diseases have been developed and continue to be developed.

In this review, it is aimed to explain the general characteristics, importance, production, advantages of DIVA vaccines and strategies and their use in various animal diseases.
Tendências e projeções de temperatura do ar e precipitação para os municípios de Monteiro e Patos (Paraíba)
Authors: Silva Louise Pereira da , Santos Paula Rose De Araújo , Ribeiro Giusep Magno da Silva , Medeiros Susane Eterna Leite , Abrahão Raphael
Published: April 2022

No presente trabalho foram realizadas análises de tendências mediante o teste de Mann-Kendall e a aplicação do modelo climático regionalizado Eta-BESM para projeções futuras por meio dos cenários RCP4.5 e RCP8.5, nos municípios de Monteiro e Patos, localizados no estado da Paraíba (Brasil). Os parâmetros selecionados foram temperatura máxima, mínima, média do ar e precipitação pluvial. Os resultados indicam que em Monteiro as temperaturas do ar apresentam tendências históricas significativas e crescentes. Em Patos foi observado o mesmo comportamento, exceto na temperatura mínima do ar. As projeções são superiores quando comparadas aos dados históricos de temperatura do ar, para o RCP8.5, e confirmam o prognóstico de que as temperaturas do ar continuarão aumentando nas próximas décadas. No cenário RCP4.5, em alguns meses a temperatura do ar é inferior ou semelhante ao período histórico. Para os cenários RCP4.5 e RCP8.5, a precipitação projetada é superior à dos dados históricos no primeiro semestre do ano para as duas localidades.
Compactação do solo em uma área livre com árvores urbanas em solos argilosos
Authors: Novaes Davidson Da Silva , Brun Eleandro José , Konig Brun Flávia Gizele
Published: April 2022

O objetivo deste estudo foi subsidiar o manejo de árvores urbanas quanto aos aspectos relativos aos solos que as sustentam, por meio da análise da compactação do solo, no entorno de árvores urbanas que possuíam afloramento de raiz, em Dois Vizinhos, PR. Os dados foram levantados em seis ruas, com amostragem do entorno de 10 árvores de espécies diferentes, comumente usadas na arborização urbana de cidades do Sul do Brasil. Observaram-se os parâmetros qualidade fitossanitária da árvore, intensidade do afloramento de raízes e compactação do solo, no entorno da árvore, que foi medida quanto à resistência à penetração no solo. A resistência à penetração no solo nas áreas livres com afloramento de raízes foi elevada, principalmente entre o tronco e o meio-fio (> 6000 kPa), mas igualmente classificada como elevada em todos os lados do tronco (> 4800 kPa), o que é indicativo de valores altamente impeditivos ao crescimento de raízes em todos os lados do tronco. Para um novo plantio nesses locais, a descompactação do solo deve ser o foco principal. Assim, para melhorar o ambiente para o crescimento de uma nova árvore, é necessário fazer a abertura de covas amplas, até cerca de 60 cm de profundidade, para descompactar o solo nas camadas mais impeditivas ao crescimento de raízes.
An investigation of scientific research and patent output of major aquaculture producers and their impact on the economic growth (2001–2016): A scientometric evaluation
Authors: St. Louis Tracy Jeanel , Pedroza Filho Manoel Xavier
Published: April 2022

Este artigo investiga o desenvolvimento científico e tecnológico da produção de aquicultura de grandes produtores globais, por meio de uma análise da cienciometria baseada em publicações e patentes, junto com o impacto desse desenvolvimento sobre o crescimento econômico. Nossa análise mostra que, durante o período de 2001−2016, a China e o Japão foram os únicos grandes países produtores de aquicultura que estavam ativos em ciência e tecnologia junto com a produção de peixes. Uma análise posterior mostrou que os principais países produtores de aquicultura são mais fracos em tecnologia e inovação do que em ciência. No entanto, este estudo não pôde confirmar diretamente o impacto do desenvolvimento da ciência e da inovação em aquicultura e piscicultura sobre o crescimento econômico. Dadas as variáveis, o artigo recomenda que, para que a aquicultura e a piscicultura fomentem o crescimento econômico em termos de ciência e tecnologia, cada país deve primeiro focar seus programas na ciência e tecnologia nesses campos. Em nível de país, o setor também depende de uma economia baseada no conhecimento, do apoio de organizações públicas para melhorar a P&D, investimentos estrangeiros diretos, fortes políticas de patentes, proteção comercial, maior qualidade do capital humano e abertura ao comércio na cultura do crescimento econômico.
Diagnóstico da frota de cerco no Sudeste e Sul do Brasil: acesso formal e oferta de matéria-prima ao mercado
Authors: Martins Raquel Rennó Mascarenhas , Pereira Hamilton Hissa , De Souza Geysa Marinho , Schwingel Paulo Ricardo
Published: April 2022

O objetivo deste trabalho foi apresentar o diagnóstico da frota de cerco em operação no Sudeste e Sul do Brasil, caracterizando o acesso formal das embarcações, bem como a oferta de matéria-prima ao mercado. A frota autorizada foi analisada por meio do número de embarcações por modalidade de permissionamento e pelas características físicas das embarcações em 2020. A oferta de matéria-prima foi avaliada pelos dados referentes aos anos 2018 e 2019 do monitoramento pesqueiro, executado no Rio de Janeiro, Santa Catarina e São Paulo. As atividades da frota de cerco e o escoamento da matéria-prima para o mercado estão concentradas nos estados do Rio de Janeiro e Santa Catarina. Na última década, a frota de cerco foi significativamente expandida, com maior impacto sobre a sardinha-laje (Opisthonema oglinum) como espécie-alvo, especialmente em Santa Catarina. Essa frota apresenta capacidade de pesca menor do que a da frota autorizada para a sardinha-verdadeira (Sardinella brasiliensis), que cresceu em menor intensidade. Diante da redução da captura da sardinha-verdadeira, os principais recursos explorados foram a sardinha-laje, em Santa Catarina, e a sardinha-boca-torta (Cetengraulis edentulus), no Rio de Janeiro. O excesso de capacidade de pesca e o uso desordenado de recursos alternativos geram preocupação quanto à manutenção dos estoques e da cadeia produtiva.
Dolgedraaid. Mogen peuters nog peuteren en kleuters nog kleuteren?
Authors: Goorhuis-Brouwer Sieneke , Levering Bas
Published: April 2022

De spontane ontwikkeling van peuters en kleuters staat onder grote druk. Niet alleen pedagogen en leerkrachten zijn bezorgd over de huidige ontwikkelingen binnen het onderwijs aan jonge kinderen, waar leerlingvolgsystemen, test- en compensatieprogrammas de overhand krijgen. Ook medisch specialisten maken zich zorgen. Meer dan vroeger zien zij hun poliklinieken volstromen met gezonde kinderen, bij wie desalniettemin een achterstand in de motorische, sociaal-emotionele of taalontwikkeling wordt verondersteld. Hieruit wordt pijnlijk duidelijk dat de variaties die bij een normaal ontwikkelingsproces horen niet altijd meer erkend worden. In deze bundel met discussiebijdragen van deskundigen uit het onderwijs, de pedagogiek, ontwikkelingspsychologie en medische wetenschappen, wordt aandacht gevraagd voor de eigen positie en identiteit van peuters en kleuters in het onderwijs. Mogen peuters nog peuteren en kleuters nog kleuteren? Orthopedagoog Sieneke Goorhuis-Brouwer is als hoogleraar spraak- en taalstoornissen bij kinderen verbonden aan de Rijksuniversiteit te Groningen. Bas Levering is lector Algemene Pedagogiek aan Fontys Hogescholen en hoofdredacteur van Pedagogiek in Praktijk Magazine.
Analisis Determinan Kemiskinan Provinsi Daerah Istimewa Yogyakarta Tahun 2015 - 2020
Authors: Nabilawaty Risma Cindy , Hutajulu Dinar Melani
Published: April 2022

Poverty is a serious obstacle to economic development in a country, especially developing countries. Poverty has the potential to generate a wide range of issues in many sectors of the economy. In fact, there are various other factors that can affect poverty. This contemplate directs to psychoanalyse the constituents that influence the impoverishment commensurate of DI Yogyakarta responsibility in 2015-2020. Fountain-heads of collections euphemistic pre-owned therein contemplate are less important collections from the fundamental Statistics superintendence (BPS) and accompanying instrumentalities and literature. The psychoanalysis disposition euphemistic pre-owned is venire collections retrogression analysis. Economic growth and the Human Development Index (HDI) have a negative but substantial i on poverty levels in Yogyakarta Province, according to the findings of the study. Factors such as the unemployment rate also have an influence on the poverty level in Yogyakarta Province, although it shows a relatively small impact. Yogyakarta Province's population growth and decline have a positive and substantial impact on the region's poverty level.
SPECIFICS OF FINANCING PRIORITY PROJECTS IN RUSSIA
Authors:   Plekhanov Russian University of Economics, Moscow, Russia, Kookueva Victoria V.
Published: April 2022

The article presents the system of financing national projects in Russia. The main goals and objectives of the sources of this funding have been studied. The data on the planned and actual volumes of financial support are systematized. Significant discrepancies in the project passport with the data of the Federal Treasury, problems of underfunding, blurring of sources between different programs were revealed, which does not allow a deep assessment of the effectiveness of their project implementation.
THE IMPACT OF THE GLOBAL STOCK MARKET ON THE RUSSIAN FINANCIAL SECTOR BEFORE AND DURING THE PANDEMIC
Authors:   Central Economics and Mathematics Institute of the Russian Academy of Sciences, Moscow, Russia, Egorova Elena N. , Vigriianova Maria S. ,   Central Economics and Mathematics Institute of the Russian Academy of Sciences, Moscow, Russia
Published: April 2022

Тhe statistical dependencies of the RTS stock indicators and the financial sector of the Russian stock market on the dynamics of the global financial stock market sector are studied. The experimental calculations were carried out and the main factors influencing the dynamics of this market in 2006–2019 (before the pandemic) and in 2020–2021 (during the pandemic) were identified. Calculations were carried out both on the dynamics of the RTS index and on the stock quotes of the largest banks as PJSC Sberbank and VTB Bank. It was shown that the COVID-19 pandemic did not have a significant qualitative impact on the closeness of the statistical relationship between the dynamics of these indicators and the indicator of the financial sector of the global stock market, since the coefficients of determination of the statistical relationship remained high.
ACTUAL PROBLEMS OF DEVELOPMENT OF THE UNIFIED SCIENTIFIC AND TECHNOLOGICAL SPACE OF THE UNION STATE OF RUSSIA AND BELARUS
Authors:   Russian University of Economics named after G. V. Plekhanov, Moscow, Russia, Morozov Ivan V. , Surilov Meir N. ,   Russian University of Economics named after G. V. Plekhanov, Moscow, Russia, Ilyina Alyona I. ,   Russian University of Economics named after G. V. Plekhanov, Moscow, Russia
Published: April 2022

The development of the unified scientific and technological space of the Union State should ensure the alignment of common priorities of the federal and regional innovation policy of Russia and Belarus in the medium term. In modern realities, when the countries participating in the integration have not recovered from the impact of the COVID-19 pandemic, the Union State has faced new external challenges associated with the escalation of the conflict between Russia and Ukraine, which led to the rupture of foreign policy and economic contacts with Western countries. In the current conditions, the model of socio-economic development of the Union State should be rebuilt on anti-crisis and anti-sanctions rails, ensuring the implementation of import substitution programs and support for innovation activity in all spheres of economic activity. The article is devoted to the identification and actualization of systemic problems of the development of the unified scientific and technological space of the Union State of Russia and Belarus in the new foreign policy and macroeconomic realities.
SHOCK IN THE POULTRY MEAT MARKET IN 2021
Authors:   Vyatka State University, Kirov, Russia, Stepanyan Vladimir Kh.
Published: April 2022

The article analyzes the poultry meat market for the year, summarizes statistical data on per capita consumption and the average price for this type of product. It was revealed that the consumption of poultry meat per person per year is 3.3 kg less than the value recommended by the Ministry of Health of Russia. It follows from statistical data on prices of agricultural producers that in 2012–2020 the price of a kilogram of poultry meat increased by 34%, and in 9 months of 2021 – by 26%. The main reasons that caused a negative reaction in the poultry meat market are given, recommendations on how to get out of this situation are given.
Langkah Strategis Implementasi Aplikasi Layanan Interaktif di Perpustakaan
Authors: Mariani Mariani , Irawati Indira
Published: April 2022

Research on interactive service applications in libraries is still mostly about the use of various applications, application development, and evaluation of service applications in libraries. Utilization of service applications places more emphasis on the technology used, including assessing technical opportunities and obstacles. No research has been found that specifically discusses the preparation and management of interactive applications in libraries. The purpose of this study is to provide an overview of the application of interactive service applications that are mostly carried out in libraries and to open opportunities to obtain other views on the implementation of interactive service applications in libraries. This study uses a qualitative method with a literature review approach. From 20 articles, three major issues are found. They are the use of library service applications, a total of twelve articles; library service application development is found in 5 articles; and evaluation of library service applications in 3 articles. Conclusion from this research is that another view is needed in the implementation of interactive service applications in the library.
Formalization of Security Requirements-A Case Study on a Web- Based Application
Authors: Mishra Aditya Dev , Mustafa K.
Published: April 2022

Security of web-based applications is one of the main concerns today. With the expanding cyberspace, utility and threats are increasing simultaneously. Like earlier, even today security is taken as an afterthought. Functional requirements override the security assurance. Therefore, different security issues such as threat, vulnerability, security breaches, etc. may arise after the deployment of web-based applications. The use of formal specifications for the security requirements while developing web-based applications is cost-effective, time-saving, and error-free. Most of the exiting models rarely deal with a formal approach. The objective of this research paper is to provide an idea about the formal specification and formal verification of web-based applications. In this paper, a novel and broad approach are proposed to specify the security requirement. The proposed approach has been verified through a case study of a web-based mobile banking application. This research paper mainly focused on the specification of security properties by considering some security requirements such as authentication, authorization, confidentiality, and integrity. These security properties are formally verified by the existing more formal tools which is an extension of the proposed work.
SAR Object Detection Using a Novel Convolutional Neural Network Architecture
Authors: Kumar Bibek , Ranjan Ranjeet Kumar , Husain Arshad
Published: April 2022

In recent years, the importance of SAR (synthetic aperture radar) image analysis is growing day by day due to the vast applications in the field of oceanography, military war, land observation, agriculture, disaster management and geography. These applications required accurate classification of highresolution SAR images. In the present study, two different machine learning techniques are applied on the SAR dataset to analyze the classification accuracy. The first classification technique is SVM (support vector machine) along with principal component analysis (PCA) for feature reduction. While, in the second technique, a novel CNN (convolutional neural network) has been proposed to perform the classification on SAR images. Essential experimental analysis has been carried out based on the MSTAR dataset. Experimental results of the current study showed that the proposed CNN model outperformed the SVM classifier with an accuracy of 98.69%
Detection of Covid-19 from Chest X-Ray Images
Authors: Sangulagi Prashant , Kumar Abhinav
Published: April 2022

The capability of deep learning on chest radiographs is diagnosed in this dissertation, and an image classifier based on the COVID-Net has been provided to categorize chest X-Ray pictures. Information augmentation was recommended to extend COVID-19 reports 17 times in the case of a little amount of COVID-19 metadata. The system aims to improve transfer learning and model integration by categorizing chest X-ray pictures into three categories: normal, COVID-19, and infectious pneumonia. Choose the models ResNet-101 and ResNet-152 with best outcomes for fusion based on accuracy and loss value, and apathetically enhance its weight percentage during the training procedure. The system can obtain 97 percent accuracy in chest X-Ray pictures post training. In the diagnosing of lung nodules, this technique offers a higher accuracy than radiologist. It can assist radiologists enhance their efficiency levels and diagnostic performance as an additional diagnostic technique.
Feature Based Depression Detection from Twitter Data Using Machine Learning Techniques
Authors: Kumar Piyush , Samanta Poulomi , Dutta Suchandra , Chatterjee Moumita , Sarkar Dhrubasish
Published: April 2022

The statistics presented by the World Health Organization attribute depression to be a primary cause of concern globally, leading to suicide in the majority of the cases if left undetected. Studies show that depression generally has an impact on the writing style and corresponding language use. The primary aim of the proposed research is to study users’ posts on Twitter and identify the attributes that may indicate depressive symptoms of online users. The paper employed machine learning approaches and natural language processing techniques for training our data and evaluating the efficiency of our proposed method. The work proposed a numerical score for each user based on the sentiment value of their tweets and demonstrated that this feature can detect depression with an accuracy of 78% with the XGBoost classifier. This attribute is combined with other Linguistic features (N-Gram+TF-IDF) and LDA to achieve an accuracy of 89% using the Support Vector Machine classifier. According to the proposed research, proper feature selection and their combinations help in achieving better improvement in performance.