bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Nasturtium Extract on Oral Cancer
Authors: Nilash Amid B. , Jahanbani Jahanfar , Jolehar Maryam
Published: October 2023

Background:

Considering the global prevalence of cancers and the complications of common cancer treatments, there is growing interest in using medicinal herbs to complement cancer treatments and reduce treatment's side effects. Therefore, we investigate the effect of the extract of Nasturtium on the viability of oral cancer cells.

Materials and Methods:

In this experimental study, we prepared aqueous extract from Nasturtium leaves and human oral cancer cells (OCC-24) and normal fibroblast cells (HF2FF cell line) from a cell bank. Then the toxic effect of different concentrations of the extract on cell viability after 24–48 hours of exposure was investigated with the methylthiazol tetrazolium assay. Ultimately, the optical density was measured at 570 nm by an Elisa Reader. Analysis of inhibitory concentration 50 (IC50) was also performed. The data were analyzed by paired Student's t-test and one-way analysis of variance.

Results:

Data showed that the extract had statistically significant anticancer effects in concentrations above 0.125 mg/ml for 24-hour exposure and in concentrations above 0.5 mg/ml for 48-hour exposure (p-value <0.05). Also, this extract had an adverse effect on the viability of normal cells; however, this effect occurred in high doses of the extract (p-value <0.05). Analysis of IC50 criteria indicates that with increasing time, a higher concentration of the extract is required to inhibit the viability of cancer cells.

Conclusion:

Because of the results, this aqueous extract can be suggested as a potential therapeutic agent in oral cancer. The best concentration of the extract was found to be 1 mg/ml.
Detection of HSV-1, HSV-2 and VZV Isolated from Cerebrospinal Fluid Samples of Children Suspected to Encephalitis
Authors: Dehghan Golnaz , Goudarzi Hossein , Saket Sasan , Kazemi Aghdam Maryam , Golrokh Mofrad Morvarid , Faghihloo Ebrahim
Published: October 2023

Background:

Encephalitis is an uncommon, serious brain infection that can cause fatality among children. The cause of most encephalitis remained unknown, yet viruses are the most well-known infectious agents that cause encephalitis. This study aimed to determine varicella–zoster virus (VZV) and herpes simplex virus type 1, 2 (HSV1/2) among individuals who are under 5 years of age in Iran.

Materials and Methods:

In this study, 149 cerebrospinal fluid samples of suspected patients of encephalitis were analyzed with some symptoms, such as seizure, fever, nausea loss of consciousness, and dizziness from Mofid Children's Hospital in Tehran, Iran. Then, the molecular evaluation of samples was performed using multiplex Polymerase Chain Reaction (PCR) for detecting HSV1/2 and VZV.

Results:

The mean age of the patients was 1.8 years. Also, 63.4% of children were male and 36.6% were female. Out of 149 tested samples, 11 (7.3%) showed the viral DNA for one of the herpes viruses (7.3%). Nine samples were HSV1 positive (6.0%) and two samples were VZV positive (1.3%). Fever and vomiting were the most frequent symptoms. The mean ± standard deviation (SD) WBC and counts in cerebrospinal fluid (CSF)-positive samples, and all included samples were 298.8 ± 552.7 cells/μL and 131.1 ± 474.6 cells/μL, respectively.

Conclusions:

Although viral encephalitis is considered a threat to children's health, with accurate diagnosis and appropriate antiviral drugs, death and neurological complications in children can be prevented.
Clinico-Mycological Study of Onychomycosis in Indian Diabetic Patients
Authors: Agrawal Sonia , Singal Archana , Grover Chander , Das Shukla , Madhu S. V.
Published: October 2023

Background:

Onychomycosis (OM) is the most common nail disorder accounting for 40–50% of all onychopathies. Onychomycosis is caused by dermatophytes in majority, mostly Trichophyton (T.) rubrum followed by T. mentragrophytes var. interdigitale. However, there is a variation in the etiological profile with the subset of population, time, and geographical location. In immunocompromised hosts, non-dermatophytic molds (NDMs) and yeasts like Candida albicans and Candida parapsilosis are the main causative agents. Diabetes mellitus (DM) is a well-established risk factor for OM.

Aim and Objectives:

This study was conducted to determine the clinical and mycological characteristics of OM in diabetic patients and to evaluate the clinico-etiological correlation, if any.

Materials and Methods:

Three hundred consecutive diabetic patients were screened, of whom 102 (34%) patients were diagnosed with OM based on clinical, mycological, dermoscopic, and histological criteria.

Results:

Distal lateral subungual onychomycosis was the most common clinical variant seen in 80 (78.43%) patients. Fungal culture was positive in 57 (55.88%) of which NDMs constituted approximately half (47.61%) of the isolates, followed by Candida species (30.15%) and dermatophytes (22.22%). The clinico-mycological correlation was performed to look for the association of various fungi with the clinical type of OM. Distal lateral subungual onychomycosis was majorly caused by NDMs (51.02%), followed by Candida species (28.57%), and dermatophytes (20.40%).

Conclusion:

Non-dermatophytic molds are increasingly incriminated as the causative organisms for OM in DM and must be considered as potential pathogens in the present scenario, thus necessitating the change in the treatment options accordingly.
Post-Traumatic Extensive Scalp Ulceration: A Diagnostic and Management Challenge!
Authors: Tyagi Meha , Grover Chander , Sharma Sonal
Published: October 2023

Dissecting cellulitis of scalp (DCS) is an uncommon inflammatory dermatosis, which can be difficult to diagnose in the absence of concomitant cutaneous markers. We present an interesting case of DCS in a 60-year-old male, with an onset after blunt trauma to head. The progression was fast and diagnosis could be achieved on multiple biopsies only. The response to therapy with a combination of oral isotretinoin and intralesional triamcinolone acetonide injections is highlighted in this difficult to treat dermatoses.
Impact on patients’ workload due to COVID-19 pandemic in a high volume radiodiagnosis department and its effect on health-care personnel of a tertiary care hospital in Bihar
Authors: Kumar Rajeev , Kumar Santosh , Kumar Arunav , Sakshi  , Jha Ashutosh , Ram Nain Kumar , Suman Sanjay Kumar
Published: October 2023

Background:

The study aimed to estimate the effect of the COVID-19 pandemic on the amount of work and mental well-being of the employees. The front-line workers of the radiodiagnosis department incorporated remarkable stress, during caring for COVID-19-infected patients, which led to new encounters of work arrangements in the department.

Methodology:

The study was piloted from April 2019 to March 2022, to estimate the amount of work and mental well-being of health workers in the Department of Radiodiagnosis at Tertiary Health Care Hospital of North India. General Health Questionnaire-12 was applied to assess the mental well-being.

Results:

Health-care personnel, who faced COVID-19 patients, were subjected to more workload and mental stress compared to others. Radiological investigation requires a very close contact with the patients and due to high infectivity, morbidity, mortality, and no definite line of treatment, it causes unprecedented mental and physical stress to radiologist, radiographer, and hospital attendants, in comparison to the other investigations.

Conclusion:

Job nature, working hours, learning level, and close contact with COVID-19 patients, affected the adverse mental status of the members of the radiodiagnosis department. Radiographers and residents were under higher mental stress compared to others. We advocated that complete support should be delivered to support the well-being of health-care personnel. Front-line workers in the department of radiodiagnosis are supposed to be low stress and workload, but high work commitment.
Pregnancy-related acute kidney injury: A narrative review
Authors: Soni Abhilasha , Bajpayee Archana , Chaturvedy Manish , Jhorawat Rajesh , Bajpai Nitin K
Published: October 2023

An acute renal insult during pregnancy increases the chances of acquiring chronic kidney disease in future by many folds; thus, the management of renal disease in pregnancy becomes increasingly important to the nephrologist. In depth understanding of normal physiological changes during pregnancy is crucial in diagnostic evaluation and management. Acute insult to kidney can happen any time during pregnancy and even in the postpartum period. The incidence of acute kidney injury during pregnancy has decreased over time due to improvement in health sector and various policies promoting woman health. Women with pre-existing renal disorders face various challenges in pregnancy including increased risk of disease progression, the potential teratogenicity of medications and various fetal implications like preterm delivery or intra-uterine death. Pre-existing autoimmune disease or diabetes mellitus requires interdisciplinary team management for favorable maternal and fetal outcome. This review highlights the physiologic changes in pregnancy, different spectrum of kidney diseases related to pregnancy and their management.
Role of percutaneous CT-guided biopsy in the characterisation of pleural diseases
Authors: Pasha Iram , Singh Anil K. , Hashim Zia , Nath Alok , Neyaz Zafar , Mishra Richa , Agrawal Vinita
Published: October 2023

Background:

Computed tomography (CT)-guided biopsy is emerging as a preferred and safe method for obtaining tissue samples in pleural diseases.

Objective:

This study aimed to evaluate the diagnostic yield and safety of percutaneous CT-guided biopsy in pleural diseases and to find CT findings predictive of malignant neoplastic pleural disease.

Material and Methods:

This retrospective study included 77 patients with pleural disease who underwent CT-guided pleural biopsies from July 2013 to May 2020. All procedures were performed with a coaxial semi-automatic biopsy device. Histopathology was performed in all cases, and additional tests such as immunohistochemistry (IHC) or microbiological analysis were carried out depending on clinical suspicion. The correlation of CT findings with final diagnosis was performed by Chi-square, Fisher's exact test and logistic regression analysis.

Results:

The overall technical success rate of CT-guided pleural biopsy was 100% with a diagnostic yield of 96.1%. No major complication was encountered, with minor complications encountered in the form of minimal pneumothorax and chest pain. Malignant pleural conditions constituted the largest group including metastatic adenocarcinoma as the most common (31.2%), followed by metastatic squamous cell carcinoma and mesothelioma. Tubercular pleural involvement was the second most common category (16.9%). The cartridge-based nucleic acid amplification test (CB-NAAT) assay had 90% sensitivity on pleural tissue in tubercular cases. CT features predictive of malignancy were irregular and nodular pleural thickening, mediastinal and diaphragmatic pleural involvement and mediastinal/chest wall invasion. There was a good correlation between higher pleural thicknesses with malignant outcome.

Conclusion:

Percutaneous CT-guided biopsy is a safe method for obtaining pleural tissue samples with high diagnostic yield. CT findings provide clues, which favour malignant pleural involvement.
Pre-extensively drug-resistant tuberculosis among pulmonary multidrug-resistant tuberculosis patients in Eastern Nigeria
Authors: Nwachukwu Ndubuisi O. , Ulasi Amara E. , Okoronkwo Christopher U. , Unegbu Valentine N.
Published: October 2023

Background:

Pre-extensively drug-resistant tuberculosis (Pre-XDR-TB), an emerging form of drug-resistant tuberculosis, is challenging efforts at tuberculosis control, leading to treatment failure among multidrug-resistant tuberculosis (MDR-TB) patients and progression to extensively drug-resistant tuberculosis (XDR-TB). We determined the rate of Pre-XDR-TB among multidrug-resistant patients in Southeast, Nigeria.

Methods:

A prospective laboratory-based study was carried out at the South East Zonal Tuberculosis Reference Laboratory from January 2021 to December 2021. Second-line drug (SLD) resistance was performed on 225 sputum samples of multidrug-resistant patients prior to treatment initiation using GenoType MTBDRsl genotypic drug susceptibility testing (DST) method.

Results:

The rate of Pre-XDR-TB among 225 MDR-TB cases was 3.1%. Fluoroquinolone-resistant Pre-XDR-TB was observed (100%) in previously treated tuberculosis cases. Only one (0.4%) case showed resistance to both fluoroquinolone (FQ) and one second-line injectable drug (XDR-TB). The extensively drug-resistant case observed was a de-novo resistance. Exactly 0.9% of the multidrug-resistant cases showed resistance to second-line injectables.

Conclusion:

The prevalence of Pre-XDR-TB among MDR-TB cases was high. There is need for rapid detection of Pre-XDR-TB among MDR-TB cases before treatment initiation.
Pharmacists Working to Avert an Avoidable Apocalypse
Authors: Alderman Chris
Published: October 2023

A recently published novel paper explored the frightening prospect of living in an imaginary world where antibiotics can no longer fulfill their valuable function in modern medicine. The authors of this piece demonstrate an interesting approach that they feel might motivate health care professionals to contemplate more carefully what can be done to preserve the utility of antimicrobials. In what is perhaps a more pragmatic approach, in this edition of the journal, we publish a joint position statement addressing the role of senior care pharmacists in antimicrobial stewardship. The position statement addresses a range of concepts, but of importance overall it speaks to the need for pharmacists to play an important role in preserving the efficacy of antibiotics.
Infectious Disease: Historic Triumphs and Future Tragedy?
Authors: Baldwin Paul
Published: October 2023

With each new source of infection has come increased understanding of the means of transmission and the development of vaccines and antibiotics to combat them. In this month's penultimate edition of Policy Currents, the author provides resources on infectious diseases for senior care and consultant pharmacists.
Lower bounds on Bourgain’s constant for harmonic measure
Authors: Badger Matthew , Genschaw Alyssa
Published: October 2023

For every
$n\geq 2$
, Bourgain’s constant
$b_n$
is the largest number such that the (upper) Hausdorff dimension of harmonic measure is at most
$n-b_n$
for every domain in
$\mathbb {R}^n$
on which harmonic measure is defined. Jones and Wolff (1988, Acta Mathematica 161, 131–144) proved that
$b_2=1$
. When
$n\geq 3$
, Bourgain (1987, Inventiones Mathematicae 87, 477–483) proved that
$b_n>0$
and Wolff (1995, Essays on Fourier analysis in honor of Elias M. Stein (Princeton, NJ, 1991), Princeton University Press, Princeton, NJ, 321–384) produced examples showing
$b_n<1$
. Refining Bourgain’s original outline, we prove that
$$\begin{align*}b_n\geq c\,n^{-2n(n-1)}/\ln(n),\end{align*}$$
for all
$n\geq 3$
, where
$c>0$
is a constant that is independent of n. We further estimate
$b_3\geq 1\times 10^{-15}$
and
$b_4\geq 2\times 10^{-26}$
.
Analgesic effect of ultrasound-guided bilateral transversus abdominis plane block in laparoscopic gastric cancer
Authors: Wang Ya-Ya , Fu Hua-Jun
Published: October 2023

Postcholecystectomy bile duct injury (BDI) remains a devastating iatrogenic complication that adversely impacts the quality of life with high healthcare costs. Despite a decrease in the incidence of laparoscopic cholecystectomy-related BDI, the absolute number remains high as cholecystectomy is a commonly performed surgical procedure. Open Roux-en-Y hepaticojejunostomy with meticulous surgical technique remains the gold standard surgical procedure with excellent long-term results in most patients. As with many hepatobiliary disorders, a minimally invasive approach has been recently explored to minimize access-related complications and improve postoperative recovery. Since patients with gallstone disease are often admitted for a minimally invasive cholecystectomy, laparoscopic and robotic approaches for repairing postcholecystectomy biliary stricture are attractive. While recent series have shown the feasibility and safety of minimally invasive post-cholecystectomy biliary stricture management, most are retrospective analyses with small sample sizes. Also, long-term follow-up is available only in a limited number of studies. The principles and technique of minimally invasive repair resemble open repair except for the extent of adhesiolysis and the suturing technique with continuous sutures commonly used in minimally invasive approaches. The robotic approach overcomes key limitations of laparoscopic surgery and has the potential to become the preferred minimally invasive approach for the repair of postcholecystectomy biliary stricture. Despite increasing use, lack of prospective studies and selection bias with available evidence precludes definitive conclusions regarding minimally invasive surgery for managing postcholecystectomy biliary stricture. High-volume prospective studies are required to confirm the initial promising outcomes with minimally invasive surgery.
Examining the impact of early enteral nutritional support on postoperative recovery in patients undergoing surgical treatment for gastrointestinal neoplasms
Authors: Chen Zhi , Hong Bo , He Jiang-Juan , Ye Qian-Qian , Hu Qiao-Yi
Published: October 2023

Postcholecystectomy bile duct injury (BDI) remains a devastating iatrogenic complication that adversely impacts the quality of life with high healthcare costs. Despite a decrease in the incidence of laparoscopic cholecystectomy-related BDI, the absolute number remains high as cholecystectomy is a commonly performed surgical procedure. Open Roux-en-Y hepaticojejunostomy with meticulous surgical technique remains the gold standard surgical procedure with excellent long-term results in most patients. As with many hepatobiliary disorders, a minimally invasive approach has been recently explored to minimize access-related complications and improve postoperative recovery. Since patients with gallstone disease are often admitted for a minimally invasive cholecystectomy, laparoscopic and robotic approaches for repairing postcholecystectomy biliary stricture are attractive. While recent series have shown the feasibility and safety of minimally invasive post-cholecystectomy biliary stricture management, most are retrospective analyses with small sample sizes. Also, long-term follow-up is available only in a limited number of studies. The principles and technique of minimally invasive repair resemble open repair except for the extent of adhesiolysis and the suturing technique with continuous sutures commonly used in minimally invasive approaches. The robotic approach overcomes key limitations of laparoscopic surgery and has the potential to become the preferred minimally invasive approach for the repair of postcholecystectomy biliary stricture. Despite increasing use, lack of prospective studies and selection bias with available evidence precludes definitive conclusions regarding minimally invasive surgery for managing postcholecystectomy biliary stricture. High-volume prospective studies are required to confirm the initial promising outcomes with minimally invasive surgery.
Bariatric surgery reduces colorectal cancer incidence in obese individuals: Systematic review and meta-analysis
Authors: Liu Ying-Ning , Gu Jing-Feng , Zhang Jian , Xing Dong-Yang , Wang Gui-Qi
Published: October 2023

Postcholecystectomy bile duct injury (BDI) remains a devastating iatrogenic complication that adversely impacts the quality of life with high healthcare costs. Despite a decrease in the incidence of laparoscopic cholecystectomy-related BDI, the absolute number remains high as cholecystectomy is a commonly performed surgical procedure. Open Roux-en-Y hepaticojejunostomy with meticulous surgical technique remains the gold standard surgical procedure with excellent long-term results in most patients. As with many hepatobiliary disorders, a minimally invasive approach has been recently explored to minimize access-related complications and improve postoperative recovery. Since patients with gallstone disease are often admitted for a minimally invasive cholecystectomy, laparoscopic and robotic approaches for repairing postcholecystectomy biliary stricture are attractive. While recent series have shown the feasibility and safety of minimally invasive post-cholecystectomy biliary stricture management, most are retrospective analyses with small sample sizes. Also, long-term follow-up is available only in a limited number of studies. The principles and technique of minimally invasive repair resemble open repair except for the extent of adhesiolysis and the suturing technique with continuous sutures commonly used in minimally invasive approaches. The robotic approach overcomes key limitations of laparoscopic surgery and has the potential to become the preferred minimally invasive approach for the repair of postcholecystectomy biliary stricture. Despite increasing use, lack of prospective studies and selection bias with available evidence precludes definitive conclusions regarding minimally invasive surgery for managing postcholecystectomy biliary stricture. High-volume prospective studies are required to confirm the initial promising outcomes with minimally invasive surgery.
Religiosity, conservatism, and value preferences as predictors of attitudes towards science
Authors: Zajas Aleksandra
Published: October 2023

Anti-science attitudes and movements have been attracting more, and more attention of researchers in the past years, especially during the pandemic. Anti-science attitudes can be defined as a dismissal of established, and empirically confirmed scientific facts for reasons that are not scientifically grounded. Previous research in social psychology has consecutively shown that this phenomenon can be predicted much better by ideological, and worldview variables than by education level. The aim of this research was to examine the role of religiosity, political orientation (conservatism), and individual value preferences in predicting four attitudes towards science, i.e.: climate change denialism, vaccination skepticism, anti-evolutionism, and general positive belief in science. The study was carried out according to the quantitative research paradigm. Hierarchical regression analysis was applied to test the predictive power of each independent variable. For each dependent variable a 3-step regression analysis was carried out, with age as control variable added in step 1, religiosity, and conservatism added in step 2, and 12 values preferences in step 3. The highest correlation could be observed between religiosity, political conservatism, anti-evolutionism, and Tradition value preference. The strongest negative correlations appeared between Universalism, and Power preference, as well as between belief in science, and anti-evolutionism. Conservatism was a positive predictor of climate change denialism, and Universalism preference predicted it negatively. Vaccine skepticism regression analysis did not bring any significant results. Anti-evolutionism was influenced by religiosity, and conservatism, as well as a lower preference of Security, Conformity, and Universalism values. Belief in science was positively predicted by Security preference, and negatively predicted by religiosity, and Tradition preference.
A Novel Implementation of QPSK Modulator on FPGA
Authors: B Reshma Parveen
Published: October 2023

QPSK is one of the digital modulation techniques in communication system that has wide applications in the field of wireless, satellite communication, Bluetooth, OFDM etc. The Conventional QPSK modulators designs are generally based on IQ approach. In these modulators multipliers are used to separate the modulating signal into the in-phase and quadrature phase which increases the hardware complexity. The objective of this work is to implement the digital QPSK modulator with conventional and another approach of digitization. In this approach a digitized carrier wave is generated and QPSK phase shifting is provided by 4:1 multiplexer according to the data bits. The implementations of both the designs are done on Spartan 3E Xilinx FPGA through the verilog hardware description language. The QPSK modulator based on the Digitized approach is simpler in terms of hardware circuitry.
Classification and analysis of key parameters in predicting the state of facultative oligotrophs in two different reservoirs
Authors:   University of Kragujevac, Faculty of Science, Serbia, Radojević Ivana , Stefanović Nenad ,   University of Kragujevac, Faculty of Technical Sciences Čačak, Serbia, Ostojić Aleksandar ,   University of Kragujevac, Faculty of Science, Serbia
Published: October 2023

This study analyzes the condition, influence and dependence of facultative oligotrophs, with different physico-chemical and biological parameters determined in the routine monitoring of the status of natural water quality. The SeLaR database was used for advanced data analysis -statistical methods and data mining. Data were analyzed for reservoirs of different morphometric qualities, different positions, trophic status and dominant bacterial communities, Gruža and Grošnica. Classification and analysis of key influencing factors were applied in this research. The results indicate that the designed data mining system can successfully analyze the condition and impact of facultative oligotrophs in open waters, thus providing new information and knowledge valuable for research investigation and decision making.
A Machine Learning approach combining omics data for Alzheimer’s Disease analysis
Authors:   Ionian University, Department of Informatics, Bioinformatics and Human Electrophysiology Laboratory, Corfu, Greece, Dimitrakopoulos Georgios Ν. , Lazaros Konstantinos ,   Ionian University, Department of Informatics, Bioinformatics and Human Electrophysiology Laboratory, Corfu, Greece, Vrahatis Aristidis G. ,   Ionian University, Department of Informatics, Bioinformatics and Human Electrophysiology Laboratory, Corfu, Greece, Krokidis Marios ,   Ionian University, Department of Informatics, Bioinformatics and Human Electrophysiology Laboratory, Corfu, Greece, Skolariki Konstantina ,   Ionian University, Department of Informatics, Bioinformatics and Human Electrophysiology Laboratory, Corfu, Greece, Vlamos Panagiotis ,   Ionian University, Department of Informatics, Bioinformatics and Human Electrophysiology Laboratory, Corfu, Greece, Exarchos Themis ,   Ionian University, Department of Informatics, Bioinformatics and Human Electrophysiology Laboratory, Corfu, Greece
Published: October 2023

Alzheimer’s disease (AD) is a complex neurological disorder whose underlying mechanisms remain elusive to this day. Molecular biology methodologies, especially techniques like single-cell RNA sequencing (scRNA-seq), offer unparalleled granularity in deciphering the disease’s cellular intricacies. However, despite the potential of scRNA-seq, comprehensive machine-learning analyses are yet to be fully harnessed. Emphasizing the multi-omics machine-learning-based approaches, which integrate diverse single-cell omics datasets, could highlight novel therapeutic targets and deepen our understanding of AD’s intricate nature. In this work, we propose a machine-learning-based method to embed gene expression into a protein interaction graph. Specifically, we model each interaction with a regression model on the participating genes and we use the R2 score as edge weight. Our aim is to detect parts of the PPI graph that differentiate between control and disease conditions. Application on a scRNA-seq AD dataset managed to identify interactions forming small subgraphs, which consisted of genes involved with biological processes related to neurons.
Implementasi Program Jari Tangan: Analisis Pelaksanaan dan Dampaknya
Authors: Syaufi Nafilah Isyfi , Luthfi Wazirul , Nur Aisyah Fatimah Winar , Achrodi Slamet , Alvin Firdausa Diaz , Nur Fadhlillah Annisa
Published: October 2023

The popularity of Corporate Social Responsibility (CSR) continues to rise, reflecting a company's commitment to addressing social and environmental issues to support sustainable development. As an example of CSR commitment, PT Pertamina EP Zona 7 Jatibarang Field has put this approach into practice. Their community development program, known as "Jari Tangan" (Independent Farming and Sustainable Food Production), is focused on developing sustainable horticulture cultivation. This research analyzes the implementation of the "Jari Tangan" program using a qualitative approach. The research findings demonstrate that this program has a positive impact on the local community in terms of economic, environmental, and social aspects. The program helps farmers increase their income, optimize land management, and introduce environmentally friendly farming practices. Additionally, the program introduces innovation in the form of the Bio-Cyclo Farming System, which helps address organic waste issues and enhances agricultural productivity. The success of the “Jari Tangan” program in Bongas Wetan Village extended to its replication in Karanganyar Village. This replication helped farmers enhance their rice harvests and income. The significance of the "Jari Tangan" program extends beyond the local context and aligns with broader sustainable development goals like poverty alleviation and sustainable agriculture improvement. The program's success is also recognized by the awards it has received in the field of CSR. Therefore, the "Jari Tangan" program not only serves as an example of a company actively engaged in sustainable development but also illustrates how appropriate innovations can generate significant positive impacts on society, the environment, and the economy.
Enterprise Architecture Patterns For Online Transportation
Authors: Usady Huyearka , Dirgahayu Teduh
Published: October 2023

Online transportation is an internet-based service where passengers can order transportation via a platform. Gojek and Grab are one of the largest platforms in Southeast Asia and dominate the online transportation market share. However, platform development generally only focuses on value creation and stakeholder regulation without considering information technology (IT) services. In practice, enterprise architecture (AE) has an important role in IT-business strategy alignment. An enterprise architect can use the AE Pattern concept to provide effective solutions when developing enterprise systems. Organizations that do not implement enterprise patterns will produce poor solution targets. Therefore, the importance of implementing the AE pattern in aligning business-IT and the lack of practice related to the AE pattern. This research uses various kinds of modeling to be able to produce AE Patterns for online transportation. The purpose of this research is to model AE patterns on business and data on online transportation. The results of the AE pattern modeling are evaluated by making a prototype design then testing with the UAT method and producing using cases/processes that are successful or appropriate.
Fraudulent Financial Reporting and Fraud Hexagon: Evidence from Infrastructure Companies in ASEAN
Authors: Naldo Reyhan Rifqi
Published: October 2023

"This study aims to analyse the factors that may influence fraudulent financial reporting using the fraud hexagon model. The subjects of this study are the infrastructure sector companies listed on the stock exchanges of every ASEAN country for the period of 2019-2021. This study uses logistic regression with F-Score as the measurement for the dependent variable. The result of this study suggests that financial target, change in BOD, and CEO’s education affect fraudulent financial reporting. While financial stability, external pressure, e-procurement, electronic whistle blowing system, change in auditor, and CEO’s military or political connection do not affect fraudulent financial reporting. This study advances the knowledge of variables that may influence fraudulent financial reporting using a few new proxies for the fraud hexagon’s element, namely the e-procurement, electronic whistle blowing system, CEO’s education, and CEO’s military or political connection. The findings of this study have provided several practical implications for the company’s stakeholders to prevent fraudulent financial reporting. In the context of the fraud hexagon, this research is the first study to date that can show the significant and positive relationship between CEOs’ education and fraudulent financial reporting. The limitations of this study are the short observation period and the low R-square of the model."
Intellectual Property in Malaysia: Initiatives, Challenges & Real Infringement Cases
Authors: Johari Razana Juhaida
Published: October 2023

"The Industrial Revolution 4.0 has improved economic and societal well-being in Malaysia, and this has necessitated creativity and invention, which has resulted in the development of intellectual property. Intellectual property rights (IPR), which include patents, copyrights, designs rights, and trademarks, are largely responsible for providing incentives and protections for creative inventions. Yet, disputes between the parties at the time of IP registration and at a later stage still occur despite the intellectual property protection being in place. Hence, this study attempts to shed light on the numerous IPR activities taken by the Malaysian government, as well as on IPR challenges, their preventative measures, and actual infringement instances. Scopus, Web of Science, Science Direct, and Google Scholar were only a few of the databases that were examined to compile the literature on the subject from 2005 to 2021. This article contributes to the public’s knowledge and comprehension of intellectual property in Malaysian business, particularly in terms of its practices and difficulties."
Production Dynamics of Groundnut and Green gram in Odisha
Authors: Hossain Sk Mosharaf
Published: October 2023

"Increased production of non-paddy crops especially pulses and groundnut assume multidimensional significance in a state like Odisha, where the rice-based cropping system is increasingly proven nonsustainable; economically and environmentally. Increased production and productivity achieved through high resource use efficiency makes farming of these crops remunerative and enhances food and nutritional security. However, the growth pattern of area, yield and production of both the crops over the decades is highly inconsistent and unstable both for Odisha and India as measured through CAGR and Cuddy-Della Valle index. Cobb-Douglas production function reported allocative inefficiency of several key inputs for both groundnut and green gram. Technical efficiency as assessed through Frontier production function amply showed high production inefficiency prevalence. To revamp the production and productivity of these two major non-paddy crops, a systematic and well-coherent measure to be promoted targeting consistent and decent growth in area and productivity. Diffusion of technical know-how and targeted capacity development program can complement the efforts to make the production cost effective and profitable."
The Role of leadership in Stimulating Innovation and the Creative Potential of the team
Authors: Rayets Margaryta
Published: October 2023

"The article investigates the significance of leadership concerning the team’s innovation and creative potential. It provides an analysis of the essential elements of effective leadership in stimulating innovation and creative potential within a team. A comprehensive depiction of the contemporary perception of a leader’s role in teamwork is presented. Additionally, the model for team development and its various stages are described, alongside the manager’s creative approach in addressing intricate challenges associated with team development. Moreover, the discussion processes corresponding to each stage are identified. The research aims to elucidate the role of leadership in stimulating the innovation and creative potential of a team. The research employed various methods, including description, analysis and synthesis, comparison, and generalization, to facilitate the study’s objectives. The study explores the perception of the leader’s role and position within a team. It investigates an approach in which the leader’s primary responsibility lies in preventing the team from encountering crises. The contemporary comprehension of the leader’s role in a team is established. Leadership is delineated as a collection of leader traits, and different types of leaders are characterized. Furthermore, the study determines the group’s perception of the leader. The concepts of leader and leadership are carefully analyzed, providing a comprehensive understanding of their implications. The components essential to effective leadership in fostering innovation and unleashing the creative potential of a team are described. These components encompass various attributes such as creativity, innovation, motivation, emotionality, business acumen, and goal orientation. The article provides an analysis of the Team Development Model, examining its principal stages and elucidating the nature of leader-team discussions at each stage. Furthermore, potential justifications for employing a creative approach to address the prevailing issues are identified. The interactions between the leader and the team are thoroughly explored, focusing on their dynamics and characteristics at each stage of the model."
The Value of Marketing Research for the Creation and Successful Implementation of Effective Strategies in the Field of Marketing
Authors: Shumkova Olena
Published: October 2023

"The article considers the importance of marketing research for the creation and successful implementation of effective strategies in the field of marketing. The problem lies in the need to understand the role of marketing research in the process of developing and implementing marketing strategies, as well as in determining their scientific and practical significance. This article uses an analytical approach based on scientific literature, which allows considering various aspects of marketing research. The authors analyze research methods used in marketing, as well as the specificity of the object and subject of research. The object of research is marketing research, which is aimed at creating and implementing effective strategies in the field of marketing. The subject of the study is the methods and approaches used in marketing research, as well as their importance for the development of marketing strategies. The scientific novelty of the article is a detailed analysis of the methods and approaches used in marketing research of digital marketing, as well as the determination of their importance for the creation and implementation of effective marketing strategies. The authors of the article emphasize the importance of marketing research in the process of making informed decisions in order to achieve success in the market. The application of marketing research is an integral part of the process of creating and successfully implementing strategies in the field of marketing. Marketing research allows you to collect and analyze information about the market, consumers and competitors, which helps businesses understand their target audience and develop effective marketing strategies. The conclusions of the article emphasize the importance of marketing research as a means of achieving market success and developing effective marketing strategies. The studies provide practical recommendations for enterprises on the use of marketing research in their activities. They emphasize the importance of understanding consumers, developing a unique offer, using effective communication channels and other strategic approaches to achieve success in the field of marketing."
Use of Social Media Platforms as a Key Element of brand Marketing Strategies
Authors: Khurdei Viktoriia
Published: October 2023

"This article delves into the exploration of social media platforms as crucial components of brand marketing strategies. It characterizes the essence of social media platforms, emphasizing the significance of social networks within this context. The primary objectives of brand strategies, specifically those deployed on social media, are explicated. Contemporary brand strategies employed on social media platforms are elucidated. The study also scrutinizes the distinct features of brand marketing strategies utilized for positioning within social networks. This research aims to unveil the intricacies surrounding the utilization of social media platforms as pivotal elements within brand marketing strategies. The object of this study centers on social media platforms functioning as integral components of the virtual environment. The research employs various methodologies, including description, analysis, synthesis, comparison, generalization, and content analysis, to achieve comprehensive insights into the subject matter. This article focuses on the examination of social media platforms as vital elements within brand marketing strategies. To fulfill the objectives of this study, an exploration is conducted on the role of social media platforms in individuals’ lives, encompassing the essence of social networks and the positioning of brand promotion within their life cycle. Additionally, the article characterizes the business opportunities arising from the integration of social media platforms as components of marketing strategies. This paper provides an in-depth examination of the advantages and disadvantages associated with leveraging social media platforms for brand promotion. It defines contemporary strategies adopted by brands on social media platforms. Additionally, the research sheds light on the pivotal role of targeting within the realm of brand promotion."
Intra-Industry trade in Manufactured Goods between India and Select Southeast Asian Nations: An Empirical Examination using the G-l Index
Authors: Khalid Nikhat
Published: October 2023

"Post the wave of industrialisation, a new order of world trade emerged, which could not be explained by the classical and neoclassical models of trade. Such a trade pattern came to be denoted as ‘Intra- Industry-Trade’(IIT), implying exchange of similar or identical goods and services within an industry or sector between countries. The ASEAN is India’s fourth largest trading partner, and their economic partnership has been growing exponentially. A high degree of IIT exists in India-ASEAN trade. The present study undertakes a comprehensive examination of IIT in manufactures between India and top five trade partners among ASEAN, i.e., Indonesia, Malaysia, Singapore, Thailand, and Vietnam during the period 1992-2020. As manufactures comprise of the most traded category between India-ASEAN, Intra-Industry trade is examined at technology level, wherein manufactures are classified into resource based, low, medium, and high technology manufactures, and at commodity category level, wherein IIT is examined based on major manufactured categories. The analysis reveals exponential increase in India’s IIT among manufactured goods with the select ASEAN countries from 1992 to 2020. Albeit the degree of IIT varies by country, which has been examined in detail. The study suggests the promotion of IIT between the partner countries such that the several benefits of IIT can be harnessed, such as, efficiency gains, improved competitiveness, increased productivity, and greater economic growth, which would be mutually advantageous to India and ASEAN countries."
Competitiveness of Fruits' and Vegetables' Exports from India
Authors: M.S. Raman,
Published: October 2023

"The study aims to evaluate the competitiveness of selected fruits and vegetables in India by using four revealed comparative advantage (RCA) indices from 2001 to 2019 based on International Trade Centre (INTRACEN) database. The results revealed that out of 25 selected fruits and vegetable products, only seven product groups namely onion fresh, cucumber & gherkin, dried vegetables, cooked or uncooked vegetables, cashewnut shelled, guava & mango and tamarind showed comparative advantage in all the RCA indices. While other fruits and vegetables exhibited comparative disadvantage in a few RCA indices. To measure the consistency across different measures of RCAs, the study used three consistency tests, namely, cardinal, ordinal, and dichotomous tests. The findings indicate that the four indices exhibit greater consistency when measured as an ordinal scale, while showing less consistency when measured as cardinal or dichotomous scales. Moreover, stability of these indices was also revealed in the analysis. The study also suggested specific strategies to boost fruits and vegetables products’ exports."
Economic Analysis of Factors Affecting Sugarcane Production in Major Sugarcane Producing States of India
Authors: Dwivedi Neha
Published: October 2023

"Sugarcane (Saccharum sp.) is one of the most significant commercial crops in the world due to its strategic position, extensive uses in every nation’s everyday life, and industrial uses for sustaining economic and nutritional needs. The present study, an economic analysis of factors affecting sugarcane production and policy implications in major sugarcane-producing states of India, centers on the objective to analyse the variables influencing sugarcane production. A secondary time series data for 14 states namely: Uttar Pradesh, Maharashtra, Karnataka, Tamil Nadu, Bihar, Gujarat, Haryana, Punjab, Andhra Pradesh, Madhya Pradesh, Uttarakhand, Telangana, Chhattisgarh, and Jharkhand, for the period 1998-99 to 2018-19 have been utilized for the present study. The variables considered in this study were area, yield, rainfall, and price (FRP). The findings imply that there was a significant linear relationship between the area and sugarcane production. The linear association of yield with production was positive but weaker than the area. Rainfall and FRP (Fair and Remunerative Prices) had a weakly positive association with production,as observed there was the insensitivity of sugarcane production to FRP and rainfall thus, efforts should be made to increase price responsiveness by reducing the sugarcane cane reservation area."
Transcriptome analysis of the allometric growth of golden pompano (Trachinotus ovatus) following soybean meal feed
Authors: Liu Bo , Liu Bao-Suo , Guo Hua-Yang , Yang Jing-Wen , Zhang Nan , Lin Xian , Zhu Ke-Cheng , Zhang Dian-Chang
Published: October 2023

Golden pompano (Trachinotus ovatus) is a marine fish of great commercial value. It was selected for a study on allometric growth using fermented soybean meal (SBM) as the primary protein source during an 8-week culture period. By comparing the gene expression levels of different individuals in the fermented soybean meal group, we discovered that 1026 genes exhibited significant changes in slow and fast-growth individuals. Among these genes, 358 showed high expression levels, while 668 showed low ones. Subsequently, we conducted go function annotation and KEGG pathway enrichment analysis on all the significantly differentially expressed genes. This analysis revealed that many of these genes were associated with oxidative phosphorylation, steroid biosynthesis, glyceride metabolism, alanine, aspartic acid, and glutamate metabolism. Identifying these differentially expressed genes is a foundation for unraveling the molecular mechanisms behind growth and development. Additionally, it provides valuable gene data for future studies on the cloning and expression of growth-related genes and offers insights for subsequent biological research.