bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnosis of Vibrio cholerae isolated from patients with Vibriosis in Thi-Qar province
Authors: Helal Kareema , Al-Mozan Hanaa
Published: December 2024

The gram-negative bacteria Vibrio cholerae is the source of cholera a severe case of diarrhea. Cholera occurs either sporadically, epidemically, or endemic. Overpopulation, untreated water supplies, and unsanitary circumstances have historically been closely linked to cholera outbreaks and pandemics. This study aimed to determine the accuracy of routine and advanced biochemical methods in diagnosing Vibrio cholerae, the extent of the prevalence of bacteria and which age groups and gender are most susceptible to infection. Stool specimens were obtained from patients suspected with cholera disease from both gender in different hospitals in Thi-Qar province through the period from September to December 2023. Cary Blair medium was used to transfer the suspicious stool specimens to the Thi-Qar province's Central Health Laboratory. Routine and advanced biochemical methods were used to diagnose Vibrio cholerae. A total of 400 specimens of stool from patients suspected cholera have been collected, only (45) isolates were given growth V. cholerae with 11.25 % in biochemical routine test while in API20 E test 41 isolates were given growth V. cholerae with 10.25%. The age group with the highest infection rate was 55–65, whereas the age group with the lowest infection rate was under 5 years. With no statistically significant difference, the illness most commonly impacted females. The results have showed different morphology characteristics of all V. cholerae isolates which grow on different media. Routine and advanced biochemical tests may not give the same results, which have prompted to search for a more accurate and faster method of diagnosis.
Tomato (Solanum lycopersicum L.) yield and quality depending on the osmotic potential and the number of stems
Authors: Mendoza-Pérez Cándido , Rubiños-Panta Juan E. , Núñez-Ramírez Fidel , Romero-Félix Celia S. , Ruelas-Islas Jesús del Rosario
Published: December 2024

Objective: To evaluate the biochemical components, physical characteristics (number of stems and fruit), and yield of Saladette tomato (Solanum lycopersicum L.), Var. Cid F1, grown under greenhouse conditions and its response to a constant increase (from 1 to 2.5 dS m-1) of the osmotic potential of a nutrient solution, during three phenological stages (transplantation, 2nd cluster fruiting, and 6th cluster fruiting) of plants subjected to a single- and two-stem training system.
Design/Methodology/Approach: A sampling was carried out in the 5th cluster to determine the physical characteristics (firmness, size, number, color) and biochemical components (total soluble solids, titratable acidity, vitamin C, lycopene, pH, electrical conductivity, and ripening index) of the fruits. The experiment was established in 2018, under a greenhouse hydroponic system at Colegio de Postgraduados. The experiment was set as randomized complete block design with four replicates.
Results: The increase of osmotic potential and pruning had a positive effect on yield and number of fruits without affecting the biochemical components. Regarding the physical characteristics, T1 had 76% large fruits, 19% medium-sized fruits, 4% small fruits, and 1% tiny fruits.
Study Limitations/Implications: This methodology should be evaluated to other tomato varieties using different substrate mixtures and rates of chemical and organic fertilizers to evaluate water response and crop yield.
Findings/Conclusions: Increasing the osmotic potential of the nutrient solution, during phenological stages of maximum water and nutrient demand and the removal of old leaves had a positive response by increasing fruit number, size, and yield.
The Impact of Mobbing on the Performance of a Higher Education Institution: The Economic and Marketing Context
Authors:   Pryazovskyi State Technical University, Razumova Hanna V. , Zaika Yuliya A. ,   Pryazovskyi State Technical University, Kurnosova Olha I. ,   Pryazovskyi State Technical University
Published: December 2024

Mobbing (bullying) at higher education institutions (HEIs) is a serious social and organizational problem that can negatively affect their effectiveness not only in terms of social atmosphere, but also in terms of economic performance and market competitiveness. The article discusses various aspects of mobbing in the educational environment, its impact on productivity, motivation and economic performance of institutions. The aim of the article is to analyze the impact of mobbing on the efficiency of higher education institutions with an emphasis on its economic and marketing consequences, as well as to develop recommendations for minimizing this phenomenon to improve the internal climate, increase the productivity of employees and strengthen the competitiveness of institutions in the market of educational services. The main causes of mobbing are studied. It is noted that organizational culture can stimulate or suppress the occurrence of mobbing in the team. The main consequences of mobbing for higher education institutions are defined. It is found that mobbing can be one of the causes of significant economic losses for higher education institutions (decrease in labor productivity, increase in staff replacement costs, loss of reputation and decrease in attractiveness for students), negatively affect the brand of higher education institutions and their competitiveness in the educational market (decrease in the quality of educational products, decrease in the number of students, threat to international cooperation), as well as negatively affect the efficiency of employees. An analysis of ways to minimize the impact of mobbing to improve both the internal climate and the external reputation and economic sustainability of HEIs is carried out. Measures to overcome mobbing have been proposed, which require HEIs to implement policies and programs that have economic value, but provide stability and increase competitiveness in the long term. An effective fight against mobbing requires investment in the corporate culture and internal climate of the institution, which is the basis of its stable development and successful marketing strategy.
Problems of Spatial Development of Ukrainian Regions in the Wartime Period
Authors:   Research Centre for Industrial Problems of Development of NAS of Ukraine, Tur Olena V. , Yeremieiev Oleksandr V. ,   Research Centre for Industrial Problems of Development of NAS of Ukraine
Published: December 2024

The aim of the article is to identify the problems of spatial development of the regions of Ukraine in the wartime period. The full-scale russian invasion provoked an aggravation of the problems of spatial development of the regions, as well as caused the emergence of new challenges related to the deterioration of the security component of the functioning of the territories of Ukraine. The security problems of the spatial development of the regions relate to the need to create decent conditions for people’s livelihoods, in particular peace. Full-scale russian aggression has exacerbated the need to solve security problems, which actualizes the need to consider the challenges of the wartime period. In this regard, it is expedient to outline the main challenges of the spatial development of the regions of Ukraine in order to differentiate approaches to their solution. Therefore, it is necessary to identify the problems of development of domestic territories in the wartime period in order to determine the key vectors of their future functioning. The article allocates such regional problems as population decline due to death of people and forced migration; negative changes in the labor market; deterioration of business conditions and relocation of enterprises. The consequences of the increase in the general and economic burden on the population of the western regions of Ukraine are studied, which consist, in particular, in the deformation of the internal labor market against the background of an increase in the supply of labor from internally displaced persons. A high probability of relocation of highly qualified specialists abroad and an increase in the need for specialists of a certain profile is noted. It is determined that such a feature of domestic regions in the wartime period as the coincidence of the beginning of the war with the pandemic of coronavirus disease requires the intensification of research on problem situations associated with the transition of crises of a certain origin into crises with other causes and nature of the development.
Methodological and Applied Principles of the State Policy of Ensuring the Economic Security of the Region
Authors:   Drohobych Ivan Franko State Pedagogical University, Siuta Sviatoslav B.
Published: December 2024

The article updates the issue of economic security management at the regional level. The aim of the research is to generalize the existing and develop new methodological and applied principles of the State policy of ensuring the economic security of the region. It is shown that the system of ensuring the economic security of the region is a specially created economic system designed to initiate, organize, implement and control the processes of guaranteeing the appropriate level of security and protection of the socioeconomic system of the region from external and internal challenges, risks and threats in the economic sphere. As a result of the generalization of the theoretical and methodological provisions, it was stated that the State policy of ensuring the economic security of the region should be interpreted as a purposeful activity of the power structures, which is implemented in accordance with the relevant principles and is aimed at achieving the desired state of the economic security of the region and the system of its provision in the form of institutional, organizational, economic and other subsystems, the mechanisms, tools and means of which are aimed at achieving a common goal, strategic and operational goals and objectives, which are based on the sustainable and structurally balanced development of the regional economy, its protection from challenges and threats, balancing and implementation of socioeconomic interests of the individual, society and the State (at the regional level). Clear differences between the concepts of the State policy of ensuring the economic security of the region and State administration and State regulation in this area have been identified. Based on these principles and as a result of the theoretical generalization of the provisions of the differentiation of State policy and strategic planning of the development of the regional economy, it was determined that the basic elements of managing the economic security of the region are the purpose, goals, principles, subjects of regulation and objects of influence, mechanisms, tools and means of implementation control.
Research of New Trends in the Confectionery Business
Authors:   Just Right: Cakes, Coffee, Gifts, Chystiukhina Anastasiia O.
Published: December 2024

The aim of this article is to determine the essence and theoretical features of new trends in the confectionery business, as well as the problems of the functioning of these enterprises and the possibilities of their further development. The main research methods used in the article are the following: induction, synthesis, analysis, comparison and generalization. Trends in the confectionery market, which are rapidly changing, reflecting the changing tastes and preferences of consumers, have been studied. Data on the most important trends of the confectionery market in 2024 based on Puratos' annual report "Taste Tomorrow" were studied. It is analyzed and predicted how artificial intelligence, conscious consumption, veganism and sustainable agriculture will dominate the confectionery, bakery and chocolate sectors in 2024. It is determined how the interest of consumers is focused on the appearance and design of confectionery products, in addition, it is found that desserts and other confectionery products should be not only tasty, but also attractive for social networks. Further, the trend towards the growth of demand for confectionery products from different countries of the world, and especially in the conditions of the popularity of healthy living and veganism, the use of natural ingredients (without artificial dyes and flavors, from pieces of real fruit, without GMOs), was surveyed. The role and preferences of chocolate for people who have given up sugar and promote a healthy lifestyle have been studied. Also the trend towards conscious consumption, environmentally friendly production and green marketing was taken into consideration. The main characteristics that determine the interest of consumers in confectionery are determined, namely in the following indicators: healthy pleasure, taste experiments, special diets, individuality and personalization, visual appeal, environmental friendliness and social responsibility, digital transformation and innovative technologies. The parameters that enable confectionery market participants to remain at the top of their development and conquer new markets have been determined. The constantly changing and developing world trends of confectionery products have been characterized, concluding that studying the indicators of sensitivity to trends, experiments and the level of striving for perfection in the confectionery market is worth to be concerned with.
Empowering Communities Through the Desa Berdaya Program: Lessons from Bligo Village
Authors: Orbawati Eny Boedi , Fadlurrahman Fadlurrahman , Sujatmiko Sujatmiko , Mukti Ari
Published: December 2024

Desa Berdaya (Empowered Village) is an acceleration initiative in rural areas utilizing an integrated approach encompassing capacity building, economy, health, education, environment, and disaster preparedness. Its primary aim is to foster and develop local institutions to address community issues. This study seeks to portray the success of community empowerment through the Desa Berdaya program in Bligo Village, initiated by the private organization Rumah Zakat, by analyzing the 5P empowerment strategies: enabling, strengthening, protecting, supporting, and maintaining. A qualitative method with a case study approach was employed. Data collection was conducted using in-depth interviews, focus group discussions, observations, and documentation. Informants were selected purposively, including Bligo Village Government officials, Rumah Zakat facilitators, women’s farming groups, the Bligo Beriman waste bank, entrepreneurs, and local community members, totaling ten informants. The findings reveal that the implementation of the Desa Berdaya program in Bligo Village does not follow specific criteria but is based on program facilitators’ recommendations, often prioritizing their home villages. Based on the 5P empowerment strategy, the enabling stage involved dialogues with the village head, community leaders, and other key members deemed capable of implementing the Desa Berdaya program. During the strengthening stage, formal groups were formed, and collaborations with various internal and external parties were initiated. The protection stage was realized by issuing official decrees for the established groups, along with financial support from Rumah Zakat, Bligo Village Government, and the Magelang Regency Agricultural Office. The supporting stage was conducted through facilitation and guidance provided by program facilitators to the community. Finally, the maintenance stage was carried out by fostering a conducive atmosphere within the empowerment groups. The Desa Berdaya program positively impacts Bligo Village, particularly in social, health, environmental, and economic aspects. The reactivation of community groups and the establishment of a waste bank, which remains well-managed, are among the significant outcomes. The people of Bligo Village have become increasingly critical in addressing social and economic issues in their community due to the continuous empowerment process, which persists to this day.
Innovative Super Steel Belt Technology and its Application in the Drying and Treatment of Iron-bearing Waste Ash in Baosteel Zhanjiang lron & Steel Co., Ltd
Authors:   School of Applied Sciences, Mongolian University of Science and Technology, Ulaanbaatar 14191, Mongolia, Qian Yu , Bold Tungalagtamir ,   School of Applied Sciences, Mongolian University of Science and Technology, Ulaanbaatar 14191, Mongolia, Batdelger Byambagar , Punsantsogvoo Munkhbaatar , Munkhtur Enkhujin ,   School of Applied Sciences, Mongolian University of Science and Technology, Ulaanbaatar 14191, Mongolia,  Main campus of MUST Baga toiruu 34, Sukhbaatar district, Ulaanbaatar, Mongolia
Published: December 2024

During the ironmaking, steelmaking and steel rolling processes,
steel enterprises generate a large amount of solid waste including
iron, zinc, dust (ash) and mud, accounting for about 10% of the
total steel production [1]. These solid wastes mainly include
fly ash or sludge of blast furnace and rotary hearth furnace
and some steel rolling sludge. The traditional way is to recycle
these sediment (ash) as ingredients and return them to sintering,
achieving internal recycling and utilization within the enterprise.
However, some of the ash contains high levels of harmful elements
such as zinc and lead. Directly returning to the batching process
will cause zinc and lead to continuous circulation and enrichment
in the system, resulting in excessive loads of zinc and lead in blast
furnaces, which seriously affects the safety, stable production, and
equipment life of steelmaking enterprises.
Simulation of the Performance of Li-Ion Batteries in DC/AC Operating Mode for Electric Vehicles
Authors:   Facultad de Físicas. Universidad Complutense de Madrid, Spain, Deu Carlos Armenta , Carriquiry Juan Pedro ,   Facultad Ingeniería. Universidad de la República, Montevideo, Uruguay
Published: December 2024

This work simulates the performance of lithium batteries for electric vehicles under different charge and discharge rates. The
simulation is based on similarity factors for power, voltage, and current, reproducing the current operation conditions of an
electric vehicle at the model scale. Most current driving modes are analyzed corresponding to discharge rates from 0.1C to
0.37C. The simulation also applies to determining the charging time using charge power in current conditions, from 6.1 kW
to 18.3 kW (0.1C to 0.3C). Driving conditions derive from equations for vehicle motion, including all forces. Tests have been
run under two configurations, continuous and alternate current circuits, to reproduce the two types of engines used by electric
vehicles. The simulation shows good agreement in charge and discharge processes, with an average deviation of 3% related to
current operating conditions and 1.6% between them, proving the validity of the simulation process.
Aircraft Engine Maintenance and Digital Twin Technology in Aircraft Engines
Authors:   Master’s degree in mechanical engineering, Iran Aircraft Maintenance Engineering License from Civil Aviation Technology College(CATC), Iran, Moghtadaei Anahita
Published: December 2024

Aircraft engine maintenance stands as a critical aspect of aviation safety and operational efficiency. Traditional methods often
rely on periodic inspections and scheduled maintenance routines, which may not fully capture the dynamic conditions and potential anomalies within the engine. This article explores the integration of digital twin technology into aircraft engine maintenance processes, offering real-time monitoring, predictive analytics, and explanations of the role of human factors in aircraft
engine maintenance are given and explain simulation capabilities to optimize maintenance strategies and enhance overall reliability. Through a comprehensive review of current practices and emerging trends, this article highlights the potential benefits
and challenges of adopting digital twin technology in the aviation industry.
Before or After - The Big Bang Paradox
Authors:   Scientifique Global Limited, Cao Yang
Published: December 2024

This article describes the hypothesis-testing experiments conducted simultaneously in time. The theoretical basis of the hypothesis is designed in a way that the null hypothesis and alternative hypothesis contradicts each other, while the alternative hypothesis cannot be theoretically reached without the null hypothesis. Modern and contemporary cosmological theories have the
common source from the Big Bang theory, albeit none guarantees the absolute correctness of it. The null hypothesis is falsified
in the experiments, without developing further cosmological theory thereon. It is an intermediate corroboration to the Conformal Cyclic Cosmology, but does not prove it. The methods adopted in the experiments adapted special relativity and quantum
physics to observational instrumentation and data science. The experiments conclude the logic in Big Bang falsification, and the
cosmological possibility in Tycho particles from the evidence of Hawking points.
Advancing Precision Drug Therapy in Pregnant Women: PBPK Modeling of Antiviral Drugs
Authors: Abdulsamed Mohamed , A Naass Ashraf , Eswani Mohamed S A , O Elbasir Mohamed , Bashir Sedigh ,   Libyan Biotechnology Research Center
Published: December 2024

PBPK/PD modeling is essential in modern drug development. Traditional drug development methods frequently rely on
trial and error, which can be time-consuming, costly, and could be risky. Predicting pharmacokinetics (PK) of drugs in
pregnant women, encompassing the intricate aspect of placental drug transfer, remains a complex task. This study was to
compare of simulated or predicted and observed (previously published approaches) pharmacokinetic parameters among
the four antiviral drugs in pregnant and non-pregnant women. In addition, this investigation endeavors to construct and
assess physiologically-based pharmacokinetic (PBPK) models specific to maternal-fetal interactions for four antiviral
drugs, Acyclovir, Emtricitabine, Dolutegravir (DTG) and Raltegravir (RAL). PBPK models were built with the Open
Systems Pharmacology software suite (PK-Sim/MoBi). Different approaches to inform placental drug transfer were
applied and compared. Model performance was evaluated using in vivo all 4 a forementioned antiviral maternal plasma
concentrations during the 2nd and 3rd trimesters and umbilical vein concentrations at delivery. All clinical in vivo data
were obtained from the International Maternal paediatric and Adolescent AIDS Clinical Trials (IMPAACT) Network
P1026s study. The PBPK models successfully predicted plasma concentration-time profiles of four antiviral drugs in
the 2nd and 3rd trimesters and most predicted PK parameters fell within a 1.33-fold error range. Predicted umbilical
vein concentrations of DTG among others were in reasonable agreement with in vivo data but were sensitive to changes
in the placental partition coefficient and transplacental clearance. Maternal-fetal PBPK modeling reliably predicted
maternal PK of previously mentioned antiviral during pregnancy. For the fetal PK, data on the unbound fraction of
highly protein-bound DTG has proven to be important to adequately capture changes in total clearance in silico. More
research efforts, along with clinical data, are needed to verify the predictions of fetal PK of antiviral. In conclusion,
the findings suggest the feasibility of employing physiologically-based pharmacokinetic (PBPK) models to assess the
disposition of antiviral drugs in pregnant women and their fetuses.
Radius Model for Some Cells in Human Body on Multiplicative Calculus
Authors: Altay Zeynep , Yılmaz Emrah , Uşen Meryem , Demirbağ Fadime
Published: December 2024

The cell is the basic structure and process unit that carries all the living characteristics of a living thing and has the ability to survive on its own under suitable conditions. The relationship of cell size with nutrient absorption and nutrient consumption in the cell membrane has been examined with the current model using the theory of differential equations in classical analysis. During these examinations, the cell considered was assumed to be spherical. In fact, the shapes of cells vary depending on their functional properties. Many have long appendages, cylindrical parts or branch-like structures. However, in this study, a simple global cell will be discussed, leaving all these complex situations aside. In the current model, the relationship between the change in the radius of the cell and the nutrient absorption and consumption in the cell membrane is detailed using classical differential equations. The answer to the question for which cell size is the consumption rate exactly balanced with the absorption rate was found in classical analysis. The current model consists of first-order differential equations. In this model, the dependent variables are the radius of the cell and the mass of the cell. The classical solutions of these models will be examined, the size of the cell and the cell membrane relationship will be examined, and details will be given with numerical examples. However, in order to consider this biological phenomenon from different perspectives and compare the results, the relevant event will be modeled using multiplicative analysis, one of the Non-Newtonian analyses. The new models will be solved using multiplicative analysis techniques, and the results will be compared with classical analysis. With this new model, it is planned to clarify the results obtained in the classical case, to reveal more clearly the relationship between the size of the cell and nutrient absorption and consumption in the cell membrane, and to obtain important results.
Microsatellite and mitochondrial DNA D-loop based analysis of genetic diversity in captive populations of Crocodylus siamensis in China
Authors: Ayub Maliha , Pan Tao , Yan Peng , Li En , Hanif Misbah , Wu Xiaobing
Published: December 2024

Reintroduction of threatened species is a common strategy used to mitigate population decline and reduce the risk of extinction. In order to assess the success of such reintroduction programs, it is critical to monitor the demographic and genetic features of reintroduced populations. In this work, we conducted a genetic assessment of the Critically Endangered crocodile species Crocodylus siamensis to determine the genetic diversity, utilising both microsatellite markers and mitochondrial DNA D-loop region. The genetic analysis revealed a moderate level of genetic diversity within the sampled populations, as indicated by the microsatellite markers (Ho = 0.505 ± 0.080; He = 0.297 ± 0.091) and mtDNA D-loop (hd = 0.622 ± 0.061; Pi = 0.01294 ± 0.00041). Notably, 22 distinct haplotypes were observed. Additionally, we identified evidence of hybridisation that might have occurred between C. siamensis and Crocodylus niloticus raising concerns about the potential compromise of the species' genetic integrity. This study represents the first genetic assessment of captive bred C. siamensis populations in China, encompassing both microsatellite and mtDNA D-loop analyses. To ensure preservation of C. siamensis, we recommend identifying and excluding hybrid individuals from conservation programmes. Our findings support the feasibility of implementing breeding and captive management plans for C. siamensis, providing a solid theoretical basis for their reintroduction and captive breeding to safeguard and augment the population of this Critically Endangered freshwater crocodile. This research marks the initial step towards establishing a scientifically sound source population for the conservation of C. siamensis in China.

Keywords: protection, reintroduction genotype, haplotypic diversity, nucleotide diversity
Evaluating Sudomotor Function: Aging, Diabetes, and the Sudomotor Autonomic Neuropathy Index
Authors:   ¹Department of Surgery and Biomedical Engineering, University of California Irvine, California, USA, Young Annie TL , Danev Slav ,   Medeia Inc, Santa Barbara, CA, USA, Lakey Jonathan RT ,   ¹Department of Surgery and Biomedical Engineering, University of California Irvine, California, USA
Published: December 2024

Assessing sudomotor function is essential for diagnosing and monitoring autonomic disorders,
especially in cases of diabetes and small fiber neuropathies. Traditional methods are effective but often
complicated and less accessible. Recent innovations, particularly the VitalScan-SudoCheck, provide
a non-invasive and rapid alternative for evaluating sudomotor function through techniques such as
Quantitative Sudomotor Axon Reflex Test (QSART) and Sympathetic Skin Response (SSR).
This study investigates the impact of aging on the risk of developing autonomic neuropathy within a
large cohort (n=143,900) using the Sudomotor Autonomic Neuropathy Index (SANI). As individuals
age from 20 to 90 years, their SANI scores increase, reflecting a higher risk of autonomic neuropathy.
Additionally, the study evaluates the effectiveness of the SANI score in detecting diabetic neuropathy
compared to clinical diagnoses made by healthcare professionals for patients with type 2 diabetes
mellitus (T2DM). The findings reveal that T2DM patients (n=2,560) have higher SANI scores than the
elderly cohort aged 80 to 90.
The SANI, developed by SudoCheck, facilitates comprehensive monitoring of autonomic health,
particularly among older adults. Despite these encouraging findings, further research is necessary
to standardize sudomotor function tests and enhance their clinical utility. By addressing the barriers
to the adoption of sudomotor assessments, this study highlights the importance of timely diagnosis in
improving patient outcomes and managing the economic impact of diabetes-related complications.
Investigation of the Relationship Between Burnout Levels and Time Management of Students of the Faculty of Sport Sciences
Authors: Bayıroğlu Gül Bahar , Alp Hulusi
Published: December 2024

The aim of the research is to examine the relationship between time management and burnout levels of students studying in sports sciences. The population of the research consisted of 640 students studying at faculty of sports sciences, and the sample group consisted of a total of 153 volunteer students randomly selected. The research was conducted using the survey model, one of the quantitative research methods. Participants in the study were asked to answer the personal information form and the time management and athlete burnout scale in the literature. In order to analyze the data obtained, frequency, arithmetic mean, standard deviation, kurtosis and skewness values were calculated. Independent t test was used for pairwise comparisons, One-Way Anova test was used for multiple comparisons, and Pearson correlation analysis was applied to examine the relationship between variables. As a result, no significant differences were detected in the participants' time management and athlete burnout scales in terms of gender and sport type variables. In the time planning sub-dimension of the time management scale; It has been determined that individuals who read books plan their time better than individuals who do not read, and individuals who participate in recreational activities do better than individuals who do not participate, depending on the age variable, the department studied.
Spor Merkezi Çalışanlarının Öğle Yemeği Kalitesinin İş Performansı ve İş Tatminine Etkisi
Authors: Dere Güven
Published: December 2024

Çalışanlarının performanslarını artırma arayışında olan işletmeler en değerli sermayesi olan çalışanlarına etki eden bütün unsurlarla ilgilenmektedirler. Bu araştırmanın amacı, işletmelerin çalışanlarına sundukları yemek hizmeti kalitesinin, çalışanların iş tatmin ve performanslarına etkilerinin tespit edilerek değerlendirilmesidir. İstanbul'da faaliyet gösteren özel spor merkezleri çalışanları bu araştırmanın çalışma grubunu oluşturmuştur. Araştırmanın örneklem büyüklüğü “n=384” belirlenmiş, 162 kadın ve 331 erkek gönüllü olarak katılmıştır. Araştırmada nicel veri toplama yöntemlerinden olan anket tekniği kullanılmıştır. Kişisel Bilgi Formu, İşyerinde Verilen Yemek Hizmetinin Kalitesi (İVYHK) Ölçeği, Minnesota İş Tatmini Ölçeği ve İş Performansı Ölçeği olmak üzere dört bölümden oluşmaktadır. Analizler SPSS (Sosyal Bilimler için İstatistik Paketi) kullanılarak yapılmıştır. Araştırma sonucunda; işletmeler tarafından sunulan yemek hizmetinin kalitesinin iş tatmini (β =0,957) ve iş performansı (β =0,891) üzerinde anlamlı ve pozitif etkisi tespit edilmiştir. Araştırma sonucunda, örgütler tarafından sağlanan yemek hizmeti kalitesinin çalışanların iş performansını ve iş tatminini anlamlı bir şekilde artırdığı tespit edilmiştir. Araştırmanın diğer sektörlere ilişkin yapılması halinde daha net sonuçların elde edilebileceği değerlendirilmektedir. Spor merkezleri özelinde tespit edilen bu sonuçlara göre; çalışanlarının iş tatmin ve performanslarını artırmayı hedefleyen işletmeler çalışanların tercih ve yapılarına uygun lezzet ve çeşitlilik, sağlıklı alternatifleri içeren menüleri çalışanlarına uygun ortamlarda sunmalıdırlar. Bu bağlamda araştırma sonucu elde edilen bilgiler ile toplu yemek hizmeti sunan işletme ve kurumların ilgisinin çekilmesi hedeflenmektedir.
Traffic-derived air pollution and brain health
Authors:   , Gerber Lora-Sophie
Published: December 2024

Traffic is a crucial contributor to urban air pollution, an environmental risk factor for a wide range of diseases, including neurological disorders. Ultrafine particles (UFP) consist of solid (non-volatile) and liquid (semi-volatile) particles with an aerodynamic diameter of ≤0.1 µm. Due to their small size, UFP can cross biological barriers, e.g., the lung epithelium, and they thus have the potential to reach and harm secondary target organs including the brain.
To date, little is known about the possible effects of exposure to UFP on brain health and function and to what extent UFP has unique features that are not well covered by regulating PM10 an PM2.5. In addition, identifying which fractions of the UFP mixture are most hazardous may guide engineers and regulators to develop strategies that reduce negative health impact and can be used to evaluate the effectiveness of guideline levels to protect human health. Therefore, the research presented in this thesis was centered around the main aim to study the neurotoxic hazards of UFP, to identify the most hazardous components of UFP, and to understand the impact of fuel alternatives to reduce the hazard of UFP. We explored the applicability of microelectrode array (MEA) recordings using rat primary cortical cells for neurotoxicity testing of UFP. Moreover, we applied a novel approach to study the neurotoxicity of UFP upon simulated inhalation exposure in vitro by combining an air-liquid interface (ALI) cultured lung model with MEA recordings in cortical cultures for neurotoxicity screening.
In summary, this thesis demonstrates that nanomaterials and UFP reduce neurotoxic hazard. However, the neurotoxic potency of traffic-derived UFP is impacted by factors affecting the chemical composition of the UFP including emission source, generation and sampling conditions, and atmospheric aging. Moreover, while MEA recordings of rat primary cortical cultures are suitable for studying the impact of nanomaterials and UFP on neuronal function, crucial elements relevant for neuroinflammation and neurodegeneration are missing in our test model. Moreover, our data suggest that combining in vitro is a promising approach to investigate systemic exposure effects, however, further development and effort are needed to capture the complexity of the whole organism in vitro.
Evaluation of the QRS detector using the Medicom-combi complex for daily monitoring of ECG and blood pressure using the MIT-BIH ECG signal test database
Authors: Khairetdinova G. A. , Fedulaev Yu. N. , Nikolaeva A. M. , Gogichaev V. A. , Evdokimov F. A.
Published: December 2024

Purpose. To evaluate the accuracy of the QRS complex detectorof the Medicom-combi complex for daily monitoring of ECG and blood pressure using the MIT-BIH ECG signal test database in accordance with the requirements of GOST R IEC60601–2–47–2017, 30324.2.47–2012.

Materials and methods. During the tests, the operation of the detector was evaluated using the MIT-BIH Arrhythmia Database, containing 48 records of 30 minutes each. Each selected QRS complex was assigned one of the following types: N (supraventricular complex, normal QRS complex, including bundle branch block), V (ventricular complex), U (complex that experts find difficult to determine) and A (artifact). Rates of sensitivity (Sen), specificity or positive predictive rate (PPR), and overdiagnosis (FPR) were determined.

Results. The sensitivity of the QRS complex detector of the Medicom-combi complex for daily monitoring of ECG and blood pressure was 99,98%, and the specificity was 99,87%. The sensitivity of determining ventricular complexes was 99,97%, the specificity of determining ventricular complexes was 99,64%. Overdiagnosis of ventricular complexes does not exceed 0,03%.

Conclusion. The Medicom-combi complex for daily monitoring of ECG and blood pressure, designed for long-term ECG monitoring, has sufficient sensitivity and specificity for analyzing Holter ECG recordings, as well as identifying ventricular ectopic complexes.
Long-term effects of treatment of acute lymphoblastic leukemia in childhood on the part of the musculoskeletal system
Authors: Karseladze N. D. , Orlova N. V. , Tiganova O. A. , Sichinava D. P. , Nalegach T. V.
Published: December 2024

Effective treatment of leukemia in children has improved both the five-year and long-term survival of patients. An increase in life expectancy requires an assessment of the long-term effects of treatment. The use of antitumor drugs such as mercaptopurin, methotrexate, tyrosine kinase inhibitors, as well as glucocorticosteroids often negatively affect the musculoskeletal system, including bone mineralization, which can lead to fractures, necrosis, arthropathy and other lesions of the musculoskeletal system, Side effects of anticancer drugs, glucocorticosteroids on bone tissue are especially important in childhood, when the skeleton is being formed and their long-term negative effect on the musculoskeletal system is no less important. The assessment of long-term consequences will make it possible to develop timely preventive measures. KEYWORDS: bone tissue, antitumor therapy, leukemia, long-term effects of treatment.
New health programs to address the demographic problem
Authors: Orlova N. V. , Goryainova S. V.
Published: December 2024

Healthcare plays an important role in solving the demographic problem. In order to raise the birth rate, a new standard of obstetric and gynecological care has been introduced. A key element of the new standard is the creation of women’s health centers. It is planned to create women’s health centers on the basis of a multidisciplinary hospital. This will make it possible to use additional hospital resources for examination, pregnancy management, maternity care, and treatment, if necessary, of the mother and newborn. As part of the medical examination, an assessment of the reproductive health of working men and women is being introduced, including screening of anti-muller hormone in women, the possibility of carrying out a genetic test of embryos, IVF, cryopreservation. All services will be provided to women through compulsory health insurance.
Effective combination therapy for telogen hair loss
Authors: Shatokhina E. A. , Khaldina M. V. , Mayransaeva S. R. , Klyushina O. Yu. , Bezborodova A. V.
Published: December 2024

Background. Telogen hair loss is one of the most common forms of alopecia, associated with a disruption in the phases of the hair growth cycle – specifically, the premature transition of the hair follicle into the telogen phase. The primary causes are the influence of triggering factors such as increased stress levels and previous illnesses. The main goal of therapy is to prolong the anagen phase and stimulate hair growth through the use of topical peptides and a multivitamin complex.

Objective. To study the effectiveness of a hair growth restoration method in the treatment of telogen alopecia using cosmetic hair growth products and dietary supplements.

Methods. The study involved 20 patients diagnosed with telogen alopecia who received treatment with the topical cosmetic products «Time to Grow» and the dietary supplement «Thick and Strong Hair» for 9 weeks. The effectiveness of the treatment was assessed at 3, 6, and 9 weeks after the start of therapy.

Results. The analysis of the study showed statistically significant changes in trichoscopy indicators in patients with telogen alopecia, demonstrating the effectiveness of using hair growth cosmetics (p<0.05). At the final assessment point, a reduction in hair loss was observed in 100 % of the subjects, along with improvements in hair quality and volume. A survey evaluating the participants’ subjective experiences demonstrated satisfaction with the treatment and adherence to the therapy.

Conclusion. The use of hair growth products and the dietary supplement «Time to Grow» has proven effectiveness in the treatment of telogen hair loss.
Features of sleep disorders in children with psoriasis and comorbid pathologies
Authors: Bychkov S. G. , Murashkin N. N. , Kozhevnikova O. V. , Epishev R. V. , Opryatin L. A.
Published: December 2024

Purpose of the study. To analyze observations of sleep disorders in children with psoriasis and comorbid diseases.

Materials and methods. This article describes clinical cases of sleep disorders in 14- and 15-year-old patients with psoriasis and comorbid diseases (psoriatic arthritis (PsA) and exogenous-constitutional obesity of the 2nd degree) who were treated at National Medical Research Center for Children’s Health of the Ministry of Health of the Russia.

Results. Based on the results of collecting anamnesis and polysomnographic study (PSG), it was found that a 14-year-old child with a combination of severe plaque psoriasis (PASI index-21.3 points) and PsA had restless legs syndrome (RLS) of moderate severity, decreased sleep efficiency, and increased sleep fragmentation due to frequent awakenings. A 15-year-old patient with severe plaque psoriasis (PASI-66 score) and grade 2 exogenous-constitutional obesity had moderate obstructive sleep apnea syndrome (OSAS), as well as increased time to fall asleep, reduced sleep efficiency, and increased sleep fragmentation due to frequent awakenings.

Conclusions. Sleep disorders are common in children with psoriasis and comorbid pathologies. At the same time, the implementation of a specific variant of dyssomnia or parasomnia depends on both the underlying disease and the concomitant ones.
Current concepts of pustular psoriasis: pathogenesis, diagnosis, treatment
Authors: Shatokhina E. A. , Egoshina I. G. , Bridan-Rostovskaуa A. S. , Kruglova L. S.
Published: December 2024

Psoriasis is a chronic skin disease with a variety of clinical forms. Rare variants of pustular psoriasis are associated with the dominance in the pathogenesis of innate and autoinflammatory immune reactions, the leading role in which is played by the cytokine IL-36. Prospects for therapy of generalized pustular psoriasis are associated with the use of inhibitors of the activity of this cytokine. Data on the efficacy of treatment of generalized pustular psoriasis with IL-17A inhibitors are limited, although the drugs are more readily available in practice. A series of clinical cases of successful use of netakimab in the therapy of generalized pustular psoriasis is demonstrated.
Knee joint injuries in the structure of injuries among elite athletes of the highest achievements
Authors: Petrova V. V. , Khan A. V. , Nazaryan S. E. , Shulepov P. A. , Petrov A. A.
Published: December 2024

The article carries out a statistical analysis of sports injuries, with the greatest attention paid to injuries of the knee joint, as the most common among athletes of a high level of professional skill in various sports. An analysis of the causes leading to injuries and operations on the knee joint was carried out, most often these are stress injuries. Risk factors for injury were analyzed.
ÇOCUK YOKSULLUĞU LİTERATÜRÜNÜN VOSVİEWER İLE BİBLİYOMETRİK ANALİZİ
Authors: Akçe İslam , Buz Sema
Published: December 2024

Çocuk yoksulluğu, giderek artan yoksul çocuk sayısı ve yoksulluğun çocuklara üzerindeki olumsuz etkileri nedeniyle küresel bir endişe kaynağıdır. Birçok ülkede çocuk nüfusunun büyük bir kısmı yoksulluk içinde yaşamaktadır, bu da insani gelişme göstergelerinin beklenenden çok daha düşük seviyelerde kalmasına neden olmaktadır. Çocuk yoksulluğu, sosyal, ekonomik ve politik temellere sahip karmaşık bir sorun olup, çözümü için çeşitli bileşenlerin işbirliği yapması gerekmektedir. Türkçe ve İngilizce literatürde "çocuk yoksulluğu" temalı araştırmaların eksikliği önemli bir boşluğu temsil etmektedir. Bu çalışmanın amacı, 2000-2023 yılları arasındaki "çocuk yoksulluğu" ile ilgili araştırmaları bibliyometrik analizle inceleyerek, literatürü Sürdürülebilir Kalkınma Hedefleri, betimsel, kavramsal, gönderme ve ortaklıklar açılarından değerlendirmektir. Bu doğrultuda; WoS veri tabanından elde edilen 622 makale VOSviewer programıyla analiz edilmiştir. Elde edilen bulgulara göre; araştırmaların çoğunluğu Sürdürülebilir Kalkınma Hedeflerinin birinci ve onuncu hedefi çerçevesinde yazılmıştır. En etkin dergi “Child Indicators Research”, en etkin yazar Yekaterina Chzken, en etkin kurum Columbia Üniversitesi olmuştur. En sık kullanılan anahtar kelimeler; “çok boyutlu yoksulluk”, “yoksunluk” ve “sosyal politika” olmuştur. Günümüze yaklaştıkça çocuk yoksulluğunun tanımı ve ölçümüyle ilgili kelimelerin daha sık kullanıldığı saptanmıştır. Tıp dergilerinin ve ekonomi yazarlarının atıf düzeyinde en yoğun bağlantılara sahip olduğu saptanmıştır. Son olarak ABD ve İngiltere’ nin çocuk yoksulluğu alanında hem en üretken ülkeler hem de en yoğun işbirliği içindeki ülkeler olduğu görülmüştür.