bluuebunny/crossref_metadata_2025 huggingface dataset:
ЗАЩИТА ПРАВ ГРАЖДАН ПРИ ПРОВЕДЕНИИ КЛИНИЧЕСКИХ ИССЛЕДОВАНИЙ ГЕНОТЕРАПИИ
Authors:   Московский государственный юридический университет имени О.Е. Кутафина, Белова Дина Александровна
Published: February 2022

Статья посвящена рассмотрению правовых механизмов, направленных на защиту жизни и здоровья граждан, участвующих в клинических исследованиях генотерапии. Доказывание причинно-следственной связи между участием в клиническом исследовании и причинением вреда жизни и здоровью, необходимое для получения страховой выплаты, представляет значительные сложности для лиц, претендующих на ее получение и являющихся слабой стороной складывающихся отношений. Предлагается закрепление опровержимой презумпции, в силу которой вред, причиненный жизни или здоровью участника клинических исследований в процессе таких исследований или в течение одного года с момента их завершения, считается находящимся в причинно-следственной связи с участием в исследовании.
ПРАВОВОЕ РЕГУЛИРОВАНИЕ ГЕНЕТИЧЕСКИХ ТЕХНОЛОГИЙ В СЕЛЬСКОМ ХОЗЯЙСТВЕ В КОНТЕКСТЕ ОБЕСПЕЧЕНИЯ ПРОДОВОЛЬСТВЕННОЙ БЕЗОПАСНОСТИ
Authors:   Московский государственный юридический университет имени О.Е. Кутафина, Воронина Наталья Павловна
Published: February 2022

Ускоренное развитие генетических технологий требует эффективного правового регулирования. Применение генетических технологий при осуществлении сельскохозяйственной деятельности позволяет решить одну из мировых проблем – проблему голода и обеспечить продовольственную безопасность. Анализ действующего законодательства свидетельствует о необходимости совершенствования правового регулирования в сфере применения геномных технологий, в том числе и в сфере сельского хозяйства. В статье сформулирован авторский подход по определению концептуальной модели правового регулирования применения генетических технологий в сельском хозяйстве.
МЕСТО РЕЗУЛЬТАТОВ ГЕНОМНЫХ ИССЛЕДОВАНИЙ В СИСТЕМЕ ОБЪЕКТОВ ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ
Authors:   Томский государственный университет, Копылов Андрей Юрьевич
Published: February 2022

На основе анализа нормативно-правовых актов, практики их применения, мнений и суждений исследователей автор приходит к выводу, что результаты геномных исследований не могут быть отнесены к какому-либо одному объекту интеллектуальной собственности. В зависимости от содержания и формы выражения такие результаты либо попадают под один из правовых режимов существующих объектов интеллектуальной собственности, либо относятся к иным охраняемым объектам гражданских прав.
[RETRACTED] Keto Burn Dx Dragons Den UK (United Kingdom) Reviews 2022 v1
Authors: not provided ketoburndenreviews
Published: February 2022

[RETRACTED]

Keto Burn Dx Dragons Den UK (United Kingdom) Reviews 2022
Geocarto International manuscript data v1
Authors: R.H. Pshegusov , Va Chadaeva
Published: February 2022

This paper presents an approach to studying rangeland degradation by integrating remote sensing data, geographic information systems, and ecological niche theory. The document provides information about the source data used in writing the manuscript.
La escuela laica y el librepensamiento
Authors: Abelló Teresa , Puente Ginés
Published: February 2022

A comienzos del año 1887, Teresa Mañé y Víctor Ferrer aceptaban la propuesta del pedagogo librepensador Bartolomé Gabarró Borràs de dirigir dos escuelas laicas, una de niñas y otra de niños, en Vilanova i la Geltrú.
La llegada de las ideas laicistas a la localidad generó una gran controversia en la prensa local. En definitiva, fueron la chispa que encendió la llama de un conflicto latente entre dos modelos sociales y políticos, que venía gestándose desde hacía años entre la población.  Republicanos federales, por un lado, y conservadores, por otro, dirimieron sus diferencias des de las páginas de los periódicos locales, visualizando la fragmentación de la sociedad vilanovense, en sintonía con la dinámica imperante en otros núcleos industriales.
Así, en las páginas del Diario de Villanueva, La Defensa, El Mensajero y El Vendaval, se plasmaría un enfrentamiento que hizo derramar ríos de tinta. El análisis discursivo de estas publicaciones antagónicas respecto el laicismo pedagógico, el catolicismo y el federalismo, es el objeto de este artículo que pretende radiografiar la situación vivida en Vilanova i la Geltrú a través de la prensa, reflejo de lo acontecido en otras localidades.
On the Process of Including Shipping in EU Emissions Trading: Multi-Level Reinforcement Revisited
Authors: Wettestad Jørgen , Gulbrandsen Lars H.
Published: February 2022

As part of the EU Green Deal initiative in 2019, the EU Commission decided to develop a proposal to include emissions from shipping in the EU emissions trading system. This occurred only one year after the Commission had heralded the emissions reduction agreement negotiated in the International Maritime Organization (IMO) as a significant step forward—thereby signalling support for the IMO process. We apply a multi-level reinforcement perspective to explain this apparent policy volte-face, resulting in a Commission proposal in July 2021 which is now moving through institutions in the EU. Such a perspective notes the “friendly” competition for leadership among central actors at various levels in the EU—particularly the Commission, the European Parliament, and leading member states. We find, first, that the inclusion of shipping is in line with the broadening ambitions of the Commission since the start of the emissions trading system. Second, until 2019, the Parliament carried the regulatory torch. A turning point in the policymaking process was the inclusion of the shipping issue in Ursula von der Leyen’s programme for getting accepted by the Parliament and elected as Commission leader in 2019. From then on, the Commission again took the lead. Third, despite the 2018 IMO agreement, progress there was deemed slow, which further motivated EU policymakers to act unilaterally.
Cultural history in the context of history of culture
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Pavlova O. Y.
Published: February 2022

The article is devoted to the definition of basic concepts and methodological principles of the organization of the humanities, in particular culture studies in a diachronic perspective. The shift of the field of cultural research in the process of understanding its historical principles is studied. In particular, there is a pattern of shifting humanities knowledge from direct identification with the field of "human sciences" ("Geisteswissenschaften") to the study of the fundamental multiplicity of human way of life, and, accordingly, exposing the transcendental status of culture and the need to understand the basic principles of interaction of different cultures in the diachronic dimension. Recognition of the original guideline of cultural diversity presupposes a rethinking of the historical sequence as an evaluative guideline, but, on the other hand, the avoidance of a futile denial of the principle of historicism in general. Thus, understanding the history of culture requires the study of cultural history as the basis of historical understanding of the very knowledge of culture. In general, the discipline – the history of culture or even "history of cultures" is derived from the concept of culture as a whole in two dimensions: defining the scope and content of the term "culture". As well as the recognition of its original non-homogeneity, and hence the need for reflection on the basic principles of its classification; the initial guideline for cultural diversity provides for the possibility of defining not only a synchronous but also a diachronic perspective; Thus, cultural history is a theoretical field of cultural research, which captures, comprehends and formulates the subject field and methodological guidelines for understanding the historical dynamics of culture in its correlation with the content of basic concepts. Thus, the subject field of cultural history implicitly provides the context of the history of culture, and the history of culture – the need to reflect on the order of organization of their theoretical and empirical guidelines.
Inicio del poblamiento prehistórico en la isla de Bioko (Guinea Ecuatorial)
Authors: Rosas Gonzalez Antonio , García Tabernero Antonio , Morales Hidalgo Juan Ignacio , Rodríguez Berriguete Álvaro , Fero Meñe Maximiliano , Esono Mba Fidel , Sánchez del Moral Sergio
Published: February 2022

El inicio del poblamiento humano en la isla de Bioko (antigua Fernando Poo) (Guinea Ecuatorial) es un tema mal conocido. Investigaciones previas establecen una secuencia de ocupación exclusivamente Holocena a pesar de que Bioko ha estado conectada con el continente durante el último periodo glacial. Con  objeto de localizar evidencias de ocupación Pleistocena se georeferenciaron  44 puntos/afloramientos, distinguiéndose sedimentos volcánicos y materiales volcano-sedimentarios eluviales y aluviales. Entre estos cabe destacar el hallazgo de una larga serie de sedimentos lacustres correspondientes a un paleolago ubicado en un cráter. A pesar de lo exhaustivo de las prospecciones no se halló ninguna evidencia de presencia humana atribuible a una cronología pleistocena. Nuestros resultados confirman una ocupación muy tardía de Bioko posterior a los 8000 años BP. La ausencia de ocupaciones previas podría obedecer a condiciones ecológicas hostiles (pluviosidad, parasitismo), aunque  es posible que las ocupaciones pleistocenas estuvieran restringidas a las zonas costeras y que estas se encuentren hoy sumergidas.
Rasgos morfométricos de los canchales y sus áreas fuente de la vertiente occidental del macizo de Las Ubiñas (cordillera Cantábrica, León)
Authors: Peña Pérez Sergio Alberto
Published: February 2022

Este trabajo muestra las principales características de los canchales situados en el entorno de La Becerrera, en la vertiente oeste del macizo de Las Ubiñas (cordillera Cantábrica). Para el estudio se ha generado la cartografía de detalle de los canchales y sus áreas fuente mediante el uso de técnicas de análisis cartográfico y trabajo de campo. El posterior tratamiento de las variables estadísticas ha mostrado la relación entre las proporciones de las áreas fuente y los canchales, siendo la longitud y la superficie del área fuente, dos factores muy importantes en la dimensión de los canchales. Las características del área fuente y la topografía del terreno donde se asientan los canchales, afectan de manera significativa en su morfología. Los canchales adoptan dos morfologías principales, taludes y conos, asociados estos últimos a la presencia de canales en el área fuente. La orientación del área fuente y del canchal pueden diferir debido a la presencia de canales de aludes en cabecera. Las pendientes de los canchales son homogéneas correspondiéndose con el ángulo de reposo de los derrubios.
A Versatile Solver of the Normal Modes for Horizontal Stratified Complicated Models
Authors: Wu Bo , Chen Xiaofei
Published: February 2022

Because of the current widespread attention and interest in surface waves, whether in theoretical study or in applications, the significantly different application scales in diverse fields and the various complex media types with special properties necessitate an effective analysis tool for computing normal modes of surface waves for different models to meet all kinds of application demands. By further improving and generalizing the algorithm of generalized reflection and transmission coefficients, we propose a versatile solver of normal modes for horizontal stratified complicated models. Under a series of tests with commonly encountered models of various types and of abnormal medium properties (e.g., low-velocity layers included, fluid sandwiched), whether on the model adaptability, on the capability of the complete computation of the normal modes, or on the stability or computing efficiency, this solver fully demonstrates that it is a powerful tool for the theoretical calculation and inversion of surface waves.
COMPARISON OF POROSITY OF CASTS PRODUCED BY HPDC AND VPDC TECHNOLOGIES
Authors:   Technical University of Kosice, Faculty of Manufacturing Technologies with a seat in Presov, GASPAR STEFAN , MAJERNIK JAN ,   The Institute of Technology and Business in Ceske Budejovice, Faculty of Technology, TUPAJ MIROSLAW ,   Rzeszow University of Technology, The Faculty of Mechanics and Technology in Stalowa Wola, PODARIL MARTIN ,   The Institute of Technology and Business in Ceske Budejovice, Faculty of Technology
Published: February 2022

The die casting technology enables the production of complex casts with good mechanical properties and high repeatability of the production within narrow tolerance limits. However, the casts are showing signs of porosity to some extent, which may reduce their mechanical and qualitative properties. The presented article solves the problem of reducing the porosity f the high pressure die casts by vacuuming the mold. Under constants technological parameters of casting, series of casts are being casted using the HPDC and VPDC technology. The indirect method of verifying the density and volume of individual samples is used to analyze the porosity of casts. At the same time, a macroscopic examination of the homogeneity of the casts is performed on selected samples. Macroscopic examination showed a detectable decrease in pore size and distribution in the casts. Based on the measurements, i tis proved that by using the vacuum pressure die casting process while maintaining the constant settings of the technological parameters of casting, a reduction in the porosity of the casts by an average of 24.4 % was achieved.
Sistema de monitorización y control de un robot cartesiano basado en PLC
Authors: Lozano Jesús , Calderón Antonio José , Miñambres Víctor , Pérez Alberto Tomás
Published: February 2022

Se presenta en esta comunicación un sistema robotizado para aplicaciones docentes. El sistema consta de un robot cartesiano de tres ejes, el soporte del robot con el área de trabajo y el sistema de control. El sistema de control está basado en un autómata Siemens S7-1200 (CPU 1214C DC/DC/DC), cuyas salidas por transistor permiten proporcionar los trenes de pulsos necesarios para el movimiento de los motores. Se ha diseñado además el armario de control, con todos los elementos del sistema y el conexionado, y un sistema SCADA – interfaz HMI para realizar el control manual del robot, moverlo a una posición absoluta o relativa a la velocidad deseada, moverlo automáticamente hasta la posición de HOME y referenciarlo o moverlo siguiendo una Tabla de comandos.
Identificación de diferentes zumos mediante nariz electrónica portátil
Authors: González Sara , Palomeque-Mangut David , Fernández Juan Álvaro , Santos José Pedro , Lozano Jesús
Published: February 2022

Se describe en esta comunicación una nariz electrónica portátil con conexión wifi para la identificación de aromas. La nariz electrónica es fácil de utilizar y es autónoma gracias a sus baterías. Consta de un sistema de una bomba para la extracción de los aromas, microsensores resistivos y un microcontrolador para el control de todo el sistema. Además tiene conexión a internet y una pantalla táctil a color. Por último, mediante un sistema de reconocimiento de patrones se procesan los datos obtenidos de los sensores para conseguir una clasificación de las muestras en categorías previamente aprendidas. Los resultados muestran que el sistema permita la clasificación de cuatro sabores de zumos diferentes.
Modelado dinámico y simulación de un robot trepador tipo serie con 4 grados de libertad
Authors: Peidró Adrián , Hortal Alba , Gil Arturo , Marín José María , Úbeda David , Reinoso Óscar
Published: February 2022

Este artículo presenta el modelado dinámico completo de un robot trepador con arquitectura serie y 4 grados de libertad. En primer lugar se obtiene el modelo cinemático del robot, modelándolo como un sistema articulado libre en el espacio. A continuación, se obtiene su modelo dinámico inverso empleando las ecuaciones de Lagrange. El modelo obtenido permite resolver la dinámica inversa del robot trepador estudiado independientemente de cuál de sus garras se fije al entorno o de cuál sea su postura en dicho entorno. El modelo obtenido ha sido implementado en una interfaz gráfica de usuario que permite simular la cinemática y la dinámica inversa del robot estudiado.
Robot nadador tipo flagelo bacteriano plano: estudio y simulación del mecanismo de propulsión
Authors: Traver José Emilio , Vinagre Blas M. , Tejado Inés
Published: February 2022

Este artículo propone una nueva técnica de propulsión para entornos viscosos basada en el movimiento de los peces que puede ser idónea para la propulsión de robots de pequeñas dimensiones. Se estudian y simulan diferentes formas de generar un movimiento de onda viajera, optando por el movimiento realizado por la categoría de peces Carangiforme. La propulsión de este tipo de peces podría modelarse mediante un filamento elástico excitado por un conjunto de actuadores piezoeléctricos distribuidos.
Arquitectura de control multimodal para robótica asistencial
Authors: Catalán José M. , Díez Jorge A , Bertomeu-Motos Arturo , Badesa Francisco J. , Puerto Rafael , Sabater José M. , García-Aracil Nicolás
Published: February 2022

Este documento presenta una arquitectura de control multimodal para robótica de asistencia, la cual trata de tener en cuenta las decisiones del usuario para mejorar en el desempeño de las tareas al mismo tiempo que se implementa un método para minimizar posibles errores en el manejo del robot mediante un control visual. A través de la información proporcionada por el sistema de eyetracking, el usuario será capaz de interactuar con el sistema para seleccionar el objeto deseado, indicar la intención de cogerlo o incluso abortar la ejecución. El sistema incorpora un sistema de tracking 3D para conocer la ubicación de los objetos con respecto al manipulador robótico. Este sistema nos sirve tanto para definir la posición que debe alcanzar el robot, como para corregir las posibles desviaciones durante la ejecución de la trayectoria.
Plataforma didáctica de bajo coste para el control de actitud y orientación de UAVs multirotor
Authors: Rico-Azagra Javier , Gil-Martínez Montserrat , Rico Ramón , Maisterra Paloma
Published: February 2022

El presente trabajo presenta el diseño y desarrollo de una plataforma didáctica de bajo coste para el control de actitud y orientación de vehículos aéreos no tripulados (UAV) de tipo multirotor. El sistema está compuesto por un UAV de cuatro rotores y una estructura mecánica que permite su rotación en los tres ángulos de Euler sin presentar desplazamiento lineal. La configuración y programación del equipo se realiza íntegramente empleando un entorno software sencillo desarrollado en Matlab-Simulink. El equipo puede ser empleado para adquirir conocimientos y validar en laboratorio estrategias de modelado experimental, sistemas de estimación y control de actitud y orientación de multirotores, y protocolos de comunicación, entre otros.
Doctus, una herramienta de e-learning innovadora para educación en automática y áreas afines
Authors: Gómez-Estern Fabio , Muñoz de la Peña David , Sánchez Cazorla Carlos
Published: February 2022

En este trabajo se presenta una nueva herramienta para su uso en docencia en asignaturas del área de Ingeniería de Sistemas y Automática, y por extensión en cualquier materia científico-técnica. Doctus es una versión completamente renovada de Goodle GMS, una aplicación que en los últimos años ha cobrado relevancia en entornos académicos con la que se ha tratado de llevar el concepto de evaluación automática mucho más allá de los paradigmas tradicionales recogidos en Moodle y herramientas afines. La extensa base de datos de ejercicios creados hasta la actualidad en Goodle y compatibles con el nuevo Doctus, permite un acceso rápido a las funcionalidades de autocorrección. Además de presentar una arquitectura software modular orientada a objetos y una interfaz mejorada, Doctus posee una serie de características innovadoras que resultan de interés práctico en el área de Automática.
Estudio dinámico del comportamiento de un robot ápodo modular e hiper-redundante
Authors: González José L. , P. Turiel Javier , Fraile Juan C. , Pérez María A. , Martín Ricardo
Published: February 2022

La aplicación de la robótica en la medicina se ha incrementado de manera significativa en los últimos años. Sin embargo todavía existen procedimientos de diagnóstico, como la endoscopia, en los que existen limitaciones importantes. Esta técnica tiene todavía un gran margen de mejora siendo de gran interés el avance de sus capacidades de acceso y maniobrabilidad, la óptica, la calidad de imagen y el desarrollo de nuevos materiales y métodos. En el presente trabajo se analizará el comportamiento físico, en especial el aspecto dinámico que afecta a un robot de este tipo con el objetivo de comprobar las características de los distintos componentes que lo forman y tener la opción de variarlos buscando la optimización de cada uno de ellos.
Nash solution as a multi-criteria decision making technique for control problems
Authors: Sabina Sánchez Helem , Vilanova Ramón , Visioli Antonio , Arrieta Orlando
Published: February 2022

. A control system problem can be viewed as a multi- objective problem due to the fact that there are many requirements to be satisfied. Nowadays, multi-objective optimization deals with this kind of problem by implementing optimization techniques, capable of searching for the Pareto set approximation, hereafter the designer needs to select the best solution that provides a good trade-off among the competitive objectives from the Pareto front approximation. Therefore, in this communication we address the problem of selecting the best trade-o_ between the conflictive objectives, this stage is called the Multi-Criteria Decision Making (MCDM). In this paper we propose to use the Nash solution as a tuning technique to select the design alternative to implement on the control system. This selection is compared with others Proportional-Integral (PI) tuning rules on the literature.
MANUAL PARA LA OBTENCIÓN Y APLICACIÓN DE VARIABLES HIDROMETEOROLÓGICAS DESDE BASES DE DATOS GLOBALES PARA LA GESTIÓN DE SEQUIAS
Authors: Araneda Cabrera Ronnie Javier , Puertas Agudo Jerónimo , Alvarez Enjo Manuel Ali , Penas López Víctor
Published: February 2022

Este manual tiene como objetivo principal ser una herramienta básica introductoria para la gestión de sequías. Este fenómeno hidrológico extremo es de los más importantes dentro de la gestión de recursos hídricos, debido a que causan anualmente inmensas pérdidas económicas y ecológicas en todo el mundo condicionando la seguridad alimentaria y calidad de vida de las personas.
Avaliação de Cursos de Aperfeiçoamento Profissional em Diagnóstico por Imagem na Odontologia: Formatos On-line e Híbrido
Authors: Cavalcanti Marcelo , Piruna Aline , Gimenez Thais
Published: February 2022

Com todas as grandes mudanças impostas pela pandemia de COVID-19, novos desafios surgiram para as instituições de ensino de formação e capacitação de profissionais de saúde. Consequentemente, estas passaram a buscar formas alternativas de manter o processo de ensino-aprendizagem. Este estudo tem como objetivo avaliar a aceitabilidade de um grupo de 42 alunos a mudança na metodologia de ensino aplicadas em dois cursos de aperfeiçoamento profissional na FFO-USP, com formatos diferentes, um com conteúdo totalmente online (Odontologia Digital: Diagnóstico por imagem) e outro híbrido (online e presencial) (Tomografia computadorizada: Conhecer, indicar e interpretar). Este trabalho também propôs avaliar a metodologia de aprendizado, as adaptações e mudanças de métodos de ensino durante e após o período crítico da pandemia COVID 19, assim como o impacto na produtividade dos cursos. O presente trabalho foi conduzido através de um estudo observacional com delimitação transversal. Os dados foram coletados através da aplicação de questionários. Os resultados encontrados demonstraram que o ensino remoto e o híbrido formam bem consolidados, por não proporcionarem grandes interferências em suas rotinas e manter a qualidade do ensino. Concluiu-se a importância da aproximação em tempo real (atividades síncronas) e presencial quando ao conteúdo de atividades práticas e ressaltando a interação do educador e o educando, na informação dos objetivos a serem atingidos, conteúdos e métodos.
Palavras-chave: Ensino híbrido. Educação a distância. Ambiente virtual de aprendizagem. Diagnóstico por imagem.
Contribuições para a Gestão de Pessoas em um Centro de Educação a Distância – CEAD
Authors: Pereira Fabiana da Costa , Lopes Taize de Andrade Machado
Published: February 2022

Temos visto, por meio dos dados do Censo da Educação Superior, o aumento significativo dos cursos a distância e do número de alunos nessa modalidade. Este artigo consiste num relato de experiência que teve como objetivo descrever como ocorre o processo de gestão de pessoas num Centro de Educação a Distância, considerando a necessidade de organização de uma equipe multidisciplinar. A experiência das autoras como gestores da EAD demonstra que é imprescindível que sejam identificados os inúmeros profissionais necessários para o funcionamento adequado do setor, pensadas algumas estratégias para um trabalho em equipe integrado e que haja suporte na estrutura organizacional através de um sistema informacional que auxilie na logística dos processos. Como considerações finais, ressaltamos a observação a três fatores essenciais que precisam estar alinhados, quais sejam: a escolha do profissional, a valorização do trabalho desenvolvido pela equipe e o desenvolvimento do sistema de produção. Estes são elementos representativos do comportamento organizacional que poderão garantir uma maior eficiência e eficácia no resultado do trabalho.

Palavras-chave: Trabalho em equipe. Equipe multidisciplinar. EAD.
Capacitação de Gestor Cultural: uma Realidade em EAD no Exército Brasileiro
Authors: Lima Jéssica Tarine Moitinho de , Costa Ludmila Leite Madeira da , Marques Fernanda Cristina Nunes Pontes
Published: February 2022

Este artigo é uma descrição e análise da experiência do projeto de capacitação Estágio Geral Interdisciplinar de Gestão Cultural, realizado em 2019 pela Diretoria do Patrimônio Histórico e Cultural do Exército, cuja finalidade é de melhor qualificar oficiais, subtenentes e sargentos na gestão de 150 Espaços Culturais do Exército Brasileiro. Em meio às temáticas discutidas aqui estão: a apresentação do cenário institucional do EB quanto aos seus Espaços Culturais; o planejamento dos módulos de Museologia e Gestão de Espaços Culturais na modalidade à distância; e a descrição dos resultados obtidos na experiência. As práticas aqui descritas, deixam espaço para aprimoramento, seja da metodologia utilizada, seja do processo de feedback da capacitação. Podemos concluir que, compartilhar este projeto junto a universidade foi fundamental para dar corpo e credibilidade ao projeto. O sucesso do programa demonstra que é possível uma educação continuada nos conhecimentos que a gestão dos Espaços Culturais demanda. A partir da documentação legal a experiência é explicitada desde a implementação até os resultados finais de conclusão do Estágio pelos militares participantes, demonstrando a concretização dos objetivos propostos, avanços em prol da valorização e preservação do patrimônio militar do Exército Brasileiro.

Palavras-chave: Educação à distância. Museologia. Gestão patrimonial. patrimônio. Exército Brasileiro.
Salt-Tolerant Rhizobia for Enhancing Common Bean (Phaseolus vulgaris L.) Productivity under Salt Stress
Authors: Laurette Ngo Nkot , Stephane Youagang Gougueu Harris , Firmin Semboung Lang , Laurence Timb Sara Augustine , Lambert Dongmo Kenfack Julio , Dieudonne Nwaga
Published: February 2022

Salinity is one of the most important abiotic factors which are responsible for lower yields. To reduce its impact, conventional methods have been unable to solve the problem at all. In this context, developing sustainable methods which increase the productivity of saline soils without harming the environment is necessary. Some microorganisms such as rhizobia are tolerant to salt stress and can then grow in saline areas. Therefore, salt tolerant (ST) rhizobia are believed to reduce the impact of salinity on plant productivity. The aim of this study is to select the major salt-tolerant isolate of rhizobia that can alleviate salt stress in the common bean. Five salt-tolerant rhizobia were used for bean inoculation in greenhouse under salt stress (0 mM, 25 mM and 50 mM). A month after sowing, plants are harvested and analyzed for nodulation, growth and biochemical stress markers production. Collected data are analyzed statistically using SPSS 12.0. Results show that plant inoculation with ISRA352, PvNk8, PvMb1, PvNk7 reduces the effects of stress through the increase of growth, total pigments and osmolytes (proline and glycine betaine) contents compared to positive and negative controls. Plant inoculation with PvMb1 and ISRA352 led to low stress at 50 mM of NaCl. PvMb1, PvNk8 and PvNj5 are good inoculants for bean cultivation even in salt-affected soils. This research study contributes to allow the cultivation of bean in salty areas. On the other hand, the study comes up with a solution for remediation of saline soils yet to be enhanced.
Comparison of Partial Laryngectomy Versus Radiotherapy for the Treatment of Early Glottic Carcinoma: Complications and Oncological Results: A Nonrandomized Clinical Trial
Authors: Jafari Mehrdad , Aghili Mahdi , Kamali Hakim Elham , Sahebi Leyla , Saedi Babak
Published: February 2022

The aim of this non-randomized clinical trial was to evaluate tumor outcomes and subjective quality of voice following radiotherapy and partial laryngectomy in early-stage glottic laryngeal cancers. Non-Randomized Clinical Trial. Otolaryngology and radiation oncology clinics of Imam Khomeini (an affiliated hospital of Tehran University of Medical Sciences) and Amir Aalam Hospitals. Fifteen patients with early-stage glottic laryngeal carcinoma were admitted to the otolaryngology clinic, divided into two treatment groups: radiotherapy and partial laryngectomy. Of the total 50 patients, 25 had a partial laryngectomy and 25 radiotherapies. The comparison of the average of the Voice Handicap Index (VHI) showed significant improvement of vocal quality after treatment for both partial laryngectomy and radiotherapy (P<0.0001 for both). But there was no significant difference in VHI mean scores between the two treatment groups (patients treated by partial laryngectomy and radiotherapy). Short- and long-term complication was higher in patients undergoing surgery than radiotherapy group (P<0.0001). With regard to oncological outcome after one and eight-year after treatment, no differences were observed in the two treatment groups; there was a significant relationship between smoking cessation and recurrence of disease in the partial laryngectomy treatment group (P=0.012). There was no significant difference in voice quality and life expectancy of patients operated on using open surgery and patients treated with radiotherapy in this series. Open surgery may have more noticeable complications than radiotherapy.
Isolated Mediastinal Langerhans Cell Histiocytosis in a 7-Year-Old Child
Authors: Miri-Aliabad Ghasem , Dahmardeh Hamid , Rajabi Mohammad Saleh
Published: February 2022

We describe the case of a 7-year-old boy who presented with suprasternal swelling. The chest computed tomography scan showed a large mass of mediastinum. Biopsy from the mediastinal mass was performed. Histologic and immunohistochemistry findings were consistent with Langerhans cell histiocytosis [LCH]. LCH should also be considered in the differential diagnosis of anterior mediastinal tumor in children.
Evaluation of mechanisms of colistin resistance in Klebsiella pneumoniae strains isolated from patients with urinary tract infection in ICU
Authors: Niazadeh Mojtaba , Nikkhahi Farhad , Robatjazi Saeedeh , Javadi Amir , Farzam Seyed Amir , Babaei Samaneh , Zeynali Parisa
Published: February 2022

Background and Objectives: One of the major causes of urinary tract infections is Klebsiella pneumoniae. Currently, few studies investigated the mechanisms of resistance to colistin in Iran. The current study aimed to determine the prevalence of plasmid and chromosome-mediated resistance to colistin in K. pneumoniae isolates.
Materials and Methods: 177 urine samples were collected from patients with urinary tract infections hospitalized in the intensive care unit (ICU) of hospitals in the city of Qazvin. K. pneumoniae isolates were identified by standard biochemical methods, resistance to colistin among K. pneumoniae isolates were tested by disk diffusion and microbroth dilution methods. The chromosomal mutation and presence of the mcr genes in colistin-resistant K. pneumoniae were evaluated by PCR.
Results: Out of 177 samples, 65 K. pneumoniae were obtained from patients in the ICU. Six colistin-resistant isolates were isolated with MIC values ≥4 μg/mL, none of them was positive for mcr1-5. In 4 isolates, missense mutation in mgrB gene resulted in amino acid substitutions and in one isolate of mgrB gene was found intact mgrB gene.
Conclusion: The results suggest that mgrB mutation was the main mutation among colistin-resistant isolates and plas- mid-borne colistin resistance was not expanded among strains.
Evaluation of the frequency of Escherichia coli pathogroups in Brassica oleracea cultivars
Authors: Razeh Fatemeh , Salmanzadeh-Ahrabi Siavosh , Zarei Roghaieh , Attaran Bahareh
Published: February 2022

Background and Objectives: Pathogenic diseases resulting from microbial contamination of food have been widely distrib- uted in many parts of the world. Among these, Escherichia coli is one of the most important foodborne pathogenic bacteria. Diarrhea is one of the major causes of children’s death in developing countries, with approximately 2 million deaths annually. The current study aimed to determine the frequency of diarrheagenic E. coli pathotypes such as Enteropathogenic E. coli (EPEC), Enterotoxigenic E. coli (ETEC), Enteroaggregative E. coli (EAEC), and Shiga toxin-producing E. coli (STEC) in Brassica oleracea cultivars in order to provide information on the assessment of diarrheagenic E. coli pathogenesis risk.
Materials and Methods: 100 samples of vegetables were collected in Tehran, including cabbage, cauliflower, broccoli and Brussels sprouts. After homogenizing samples, enrichment was done in the EC broth medium. Five colonies of pure culture were used for DNA extraction. Pathotypes were identified by PCR using virulence genes.
Results: The results showed that the prevalence of diarrheagenic E. coli strains was 7%. The EPEC prevalence was 3%, All EPEC isolates were atypical. The ETEC frequency was 3%, And the EAEC prevalence was 1%.
Conclusion: These findings indicated that Brassica oleracea cultivars could be consideredas a source of contamination with diarrhea-causing E. coli strains.
Effect of extracellular vesicles of Lactobacillus rhamnosus GG on the expression of CEA gene and protein released by colorectal cancer cells
Authors: Keyhani Gissou , Mahmoodzadeh Hosseini Hamideh , Salimi Ali
Published: February 2022

Background and Objectives: Almost all living cells secret nano-sized structures enclosed by the lipid bilayer called extra- cellular vesicles (EVs) into their extracellular milieu. These EVs play important roles in several physiological processes as a cargo delivery system. In probiotics, EVs are the main communication tool with the host. The present study aimed to assess the effect of EVs originated from Lactobacillus rhamnosus GG on the Carcinoembryonic antigen (cea) gene expression and protein (CEA) synthesis in the SW480 and HT-29 cell lines.
Materials and Methods: Different concentrations of Lactobacillus rhamnosus GG EVs were applied on the SW480 and HT-29 cell lines. The MTT assay, Real-Time PCR, and ELISA analysis methods were exploited to explore the cell viability and the expression level of the cea gene in comparison with the β-actin gene as the control.
Results: The two concentrations of 80 and 100 μg/ml of Lactobacillus rhamnosus GG EVs considerably affected the an- ti-proliferation and increased the amount of both CEA mRNA and protein (p < 0.05).
Conclusion: Our findings showed that EVs of Lactobacillus rhamnosus GG could induce the gene expression and protein synthesis of CEA. Also, they reduced the cell proliferation of HT29 and SW480. Thus, probiotics such as EVs of Lactoba- cillus rhamnosus GG could be useful for preventing colorectal cancer.
Investigation of human parvovirus B19 prevalence in a large healthy umbilical cord blood donors
Authors: Ramezany Hooman , Kheirandish Maryam , Samiee Shahram , Khosravifar Mina , Hashemi Seyedeh Melika
Published: February 2022

Background and Objectives: Umbilical cord blood (UCB) was used to source hematopoietic stem cells in the past. Despite the apparent advantages of UCB transplantation, virus reactivation poses a considerable danger in allogeneic hematopoietic stem cell transplantation (HSCT). Human Parvovirus B19 is regarded as a potential threat to UCB contamination. This study aimed to evaluate the prevalence of parvovirus B19 in cord blood donors by Semi-Nested PCR. This study is the first large- scale report of the B19 DNA in cord blood donors in Iran.
Materials and Methods: A total of 691 umbilical cord blood were collected under standard procedure. Then, DNA from buffy coat and plasma were extracted, and semi-nested PCR was performed for all samples.
Results: Two out of 691 samples (0.29%) indicated viremia in plasma and buffy coat.
Conclusion: In this line, designing and validating a quantitative PCR assay for detection, quantification, and discrimination of Human B19 DNA genotypes of cord blood donors is necessary to enhance the safety of this source of stem cells.
Evaluation of catalase activity of clinical and environmental isolates of Aspergillus species
Authors: Gharaghani Maral , Jafarian Hadis , Hatami Maryam , Shabanzadeh Mahboubeh , Zarei Mahmoudabadi Ali
Published: February 2022

Background and Objectives: Catalases are a good scavenger of H2 O2 which degrades hydrogen peroxide into water and 2 2 oxygen. They are considered as a virulence factor that are present in both spores and hypha of fungi. There is limited data regarding catalase activity in Aspergillus species. This study aimed to assess the mycelial catalase activity of clinical and environmental isolates of Aspergillus niger, A. tubingensis, A. flavus, A. luchuensis, A. piperis and A. terreus.
Materials and Methods: Briefly, clinical and environmental Aspergillus species were used in the current study. Catalase ac- tivity was assessed for both groups of isolates including 13 A. flavus (12 clinical, 1 environmental), 13 A. terreus (8 clinical,  5 environmental), 26 A. tubingensis (13 clinical, 13 environmental), and 44 A. niger (25 environmental, 19 clinical) species. Fungal balls of mycelia were separated from the liquid culture and were crushed using homogenizer. The supernatants were collected and used for a catalase activity assay.
Results: Totally, in our study 98 Aspergillus including 45 environmental and 53 clinical isolates were assessed for catalase activity. High catalase activity was detected among environmental Aspergillus species (Mean= 1.62 mU/ml) and the mean of mycelial catalase activity among clinical A. terreus isolates was higher than environmental strains.
Conclusion: In summary, mycelial catalase activity varied among species and environmental isolates demonstrated higher catalase activity. Totally a significant difference was found between clinical and environmental Aspergillus isolates.
The Effect of Eight Weeks of Voluntary Wheel Running Exercise with Royal Jelly Consumption on Behavioral Disorders and Antioxidant Capacity in Rats with Trimethytin Model of Alzheimer’s Disease
Authors: Azimpour M , Fathi M , Dezfoulian O
Published: February 2022

Background & Objective: Alzheimer is a neurodegenerative disease in which numerous changes occur in the patient's brain, since it is suggested that royal jelly (RJ) and Physical activity have several pharmacological activities, including neuroprotective and improvement of cognitive function. This study aimed to investigate the effect of eight weeks of voluntary wheel running exercise with royal jelly consumption on behavioral disorders and antioxidant capacity in rats with Trimethytin model of Alzheimer’s disease.
Materials & Methods: This experimental study was performed on 48 male rats; Alzheimer's Trimethytin was induced on 40 rats. The rats were then randomly divided into six groups each group consisting of 8 members: healthy control group (HC), Alzheimer control group (ADC), voluntary exercise (VW) (wheel running), sham (SH), voluntary exercise combined with the royal jelly intake (VWJ) and royal jelly intake (RJ). Voluntary wheel running was done for eight weeks, three sessions per week and 60 minutes each session. To determine depression and anxiety, The Forced Swimming Test (FST) and Elevated Plus-Maze (EPM) were used respectively. Real-Time PCR was used to determine Gene expression of Superoxide dismutase (SOD) and Glutathione peroxidase (GPX). Data analysis was performed by the multivariate analysis of variance (MANOVA) test and post hoc Scheffe at the significance level of P <0.05 using SPSS software version 20.
Results: The results of multivariate analysis of variance show that there is a significant difference in all five variables of OAT, SOD, GPX, OAE and immobility in at least one group. According to the results of Scheffe post hoc test the findings showed that immobility time decreased in the VWJ, RJ, HC groups. The anxiety related indices increased in VWJ, RJ, HC groups. Although the differences in SOD antioxidant index were not significant, Gene expression of GPX increased in VWJ and RJ groups.
Conclusion: In this study, voluntary exercise alone did not reduce anxiety and depression, and this highlights the role of Royal Jelly in it, and the results with the effect size of 0.757 showed the greatest effect on reducing the depression index. It seems that the combination of voluntary exercise with royal jelly supplementation can modulate behavioral disorders and antioxidant capacity in rats with trimethylettin-induced Alzheimer’s disease.
Investigating the Relationship between Positive and Negative Affect Experiences and Resilience and Tolerance of Ambiguity among Patients with HIV
Authors: Babaei Nadiluei K , Gholmohammadzade S , Mohammadpur ASL A , Sattari M
Published: February 2022

Background & Objective: Patients with HIV experience considerable negative affects, which may jeopardize their physical, mental, and social health. On the other hand, resilience and ambiguity tolerance in challenging situations may increase the psychological health of high-risk individuals, specifically HIV patients who are exposed to high levels of risk and stress. Hence, the present study aimed to investigate the relationship between positive and negative affect experiences and resilience and ambiguity tolerance among patients with HIV in 2019.
Materials & Methods:  This study used a descriptive-correlational design. Out of the HIV patients recorded in Hematological and Oncological Research Center, Tabriz University of Medical Sciences, 95 cases were selected via simple random sampling method and, then, they were included in the study. Afterwards, data collection was performed using resilience, ambiguity tolerance, and PANAS (positive and negative affect schedule) questionnaires. Subsequently, multiple regression analysis was used to analyze the collected data.
Results: There was a significantly negative relationship between the negative affect experiences and ambiguity tolerance and resilience. Besides, the positive affect experiences were shown to have a significantly positive relationship with resilience and ambiguity tolerance. In addition, results of the regression demonstrated that the resilience and ambiguity tolerance variables could appropriately predict the positive and negative affect experiences.
Conclusions: Considering the difficult conditions of the patients with HIV as well as their great number of problems, it might be possible to reduce the experiences of negative affect and, as a result, prevent the consequent outcomes of negative affect by increasing ambiguity tolerance and resilience.
The Effect of Cerastoderma lamarcki and Rice Bran Extract on Wharton's Jelly-Derived Mesenchymal Stem Cells Differentiation
Authors: Nosrati F , Mohseni Kouchesfahani H , Nabiuni N , Karimzadeh L , Dorazehi F
Published: February 2022

Background & Objective: Nowadays, the use of natural materials in regenerative medicine is very important, especially using substances with calcium carbonate structure due to their similarity to the bone structure. In this study, the effect of Cerastoderma lamarcki shell and rice bran extract on stem cell proliferation and differentiation has been investigated.
Materials & Methods: First, crastoderma shells were collected and cut into small pieces. Its compounds were analyzed by X-ray diffraction. Finally, the structural features of shells were investigated by SEM. Stem cells were extracted and cultured from the umbilical cord of Wharton's jelly. After cells seeding on the scaffold, cell survival was studied by MTT. Adhesion, morphology, and diffusion of cells on the shells were also examined by SEM. Cells were stimulated by osteogenic medium and osteoblastic differentiation by alkaline phosphatase activity was studied. Rice bran ethanolic extract was used. Cell survival was studied by MTT technique and osteogenic differentiation was studied by Alizarin Red staining.
Results: MTT studies showed appropriate adhesion of cells on the scaffold and SEM studies also showed successful binding and their appropriate morphology on the scaffold. Alkaline phosphatase studies showed that osteogenic differentiation of cells on shells is significant. In another part of this study, we studied the survival and osteogenic differentiation of these cells in treatment with ethanolic extract of rice bran. MTT studies showed a dose-dependent decrease in cell survival in the presence of the extract. Alizarin staining also showed the differentiation potential of this substance.
Conclusion: The results showed the appropriate potential of these two natural substances in bone differentiation. However, further studies are needed to prove their effects.
Antioxidant, Antimicrobial and Antiangiogenic Properties of Corylus Avellana Essential Oil Nanoemulsion (CAEO-NE)
Authors: Gholami H , Homayouni Tabrizi M , Ardalan T
Published: February 2022

Background & Objective: Corylus avellana essential oil (CAEO) due to its individual phytochemicals and phenolic compounds has been recognized as a potent cell-protective compound against oxidative stresses. In the current study, CAEO was encapsulated in the nanoemulsion drug delivery system to improve its bioactivity properties assuming antioxidant, antimicrobial, and anti-angiogenic potentials.
Materials & Methods: CAEO nanoemulsions (CAEO-NE) were synthesized applying a high energy ultrasonic method for the emulsification processes and were characterized by DLS, AFM, and SEM analysis. Their antioxidant activity was evaluated by measuring the radical scavenging effect on both DPPH and ABTS free radicals. The CAEO antibacterial and antiangiogenic potentials were studied by measuring the non-growth ring diameter of the staphylococcus aureus culture plate and monitoring the blood vessels of the chick chorioallantoic membrane and its length, respectively.
Results: The 45.9-nm CAEO-NE significantly inhibited both DPPH and ABTS free radicals. Meaningful antibacterial and antiangiogenic impacts were detected following increasing CAEO-NE treatment doses (P-value < 0.001).
Conclusion: CAEO-NE exhibited three key medicinal activities (antioxidant, antibacterial, and antiangiogenic), which make it a potentially safe antibacterial compound. It is suggested that CAEO-NE has anticancer potential due to its antioxidant and antiangiogenic effects. However, further in vitro and in vivo studies are required to verify its mentioned bioactivities and define details of its mechanism.