bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Financial Distress pada Perusahaan PT Pembangunan Perumahan menggunakan Model Altman Z-Score dan Zmijewski Periode 2020-2022
Authors: Rena Mustari Mokoginta
Published: February 2024

Abstract : Financial distress refers to the state of a company encountering financial difficulties due to increased debt. The cumulative debt of PT Pembangunan Perumahan (PTPP) had consistently risen from 2020 to 2022. This study aimed to determine the PTPP company's financial condition for 2020-2022 by employing the Altman Z-Score and Zmijewski models. This research utilised descriptive type. The study’s findings indicated that the Altman Z-Score model classified the PTPP company as being in the grey zone situation in 2020 and 2022. In 2021, the PTPP company encountered a distressed state of bankruptcy. The calculations using the Zmijewski model method demonstrated that the PTPP company was in an appropriate condition or was not encountering financial distress in 2020, 2021, and 2022.
Abstrak : Financial distress adalah kondisi keuangan perusahaan yang mengalami kesulitan keuangan karena meningkatnya jumlah utang yang dimiliki perusahaan. Total utang yang dimiliki oleh perusahaan PT Pembangunan Perumahan (PTPP) dari tahun 2020 sampai tahun 2022 terus mengalami peningkatan. Tujuan penelitian ini adalah untuk mengetahui perusahaan PTPP mengalami financial distress atau tidak dengan menggunakan model Altman Z-Score dan Zmijewski periode 2020-2022. Jenis penelitian ini adalah deskriptif. Hasil penelitian menunjukkan model Altman Z-Score perusahaan PTPP tahun 2020 dan tahun 2022 masuk dalam kondisi grey zone. Tahun 2021 perusahaan PTPP masuk dalam kondisi distress zone atau kondisi kebangkrutan. Hasil perhitungan menggunakan metode model Zmijewski perusahaan PTPP tahun 2020, 2021 dan 2022 masuk dalam kondisi sehat atau tidak mengalami financial distress.
Analysis of Women's Representation in Indonesian Films
Authors: Putri Siti Aminah
Published: February 2024

Film is a mass media that has a strong influence in shaping public perception. Representation of women in films can reflect the values and social norms that apply in society. This research aims to analyze the representation of women in Indonesian films. The method used is Roland Barthes' semiotic analysis model. Research data was obtained from three Indonesian films, namely "Marlina Si Pembunuh dalam Empat Babak", "Siti", and "Perempuan Berkalung Turban". The research results show that the representation of women in Indonesian films can be divided into two categories, namely: 1. Women as sexual objects. This representation shows women as weak, passive, and only as sexual objects. This can be seen in the film " Marlina Si Pembunuh dalam Empat Babak ", where Marlina is depicted as a weak woman who is a victim of rape. 2. Women as agents of change. This representation shows women as strong, independent, and able to act as agents of change. This can be seen in the films "Siti" and "Perempuan Berkalung Turban", where Siti and Annisa are depicted as female figures who dare to fight injustice and fight for women's rights.
PENYULUHAN HIPERTENSI MELALUI PELATIHAN BREATHING EXERCISE PADA LANSIA DI DUSUN NGARAN BALECATUR KECAMATAN GAMPING KABUPATEN SLEMAN
Authors: Rofiatun* Rofiatun , Lifsantin Na'ima Aisyah , Ayu Puspita Shinta , Achmad Febrian , Zahra Putri Aulia Dellia , Lian Nugroho Prayuda , Saputri Vinna
Published: February 2024

Hipertensi merupakan peningkatan tekanan darah sistolik mencapai ≥ 140 mmHg dan tekanan darah diastolik ≥  90 mmHg. Upaya yang dapat dilakukan untuk mengendalikan angka kejadian hipertensi yaitu dengan penanganan farmakologis dan non-farmakologis. Penanganan farmakologis dapat dilakukan dengan menggunakan obat antihipertensi, sedangkan untuk penanganan nonfarmakologis dapat dilakukan dengan mengurangi asupan garam, menurunkan konsumsi kafein dan alkohol, menurunkan berat badan, dan melakukan latihan/ exercise. Breathing exercise merupakan intervensi non-farmakologi yang berguna dalam mengendalikan hipertensi. Tujuan dari kegiatan pengabdian masyarakat ini adalah memberikan penyuluhan hipertensi melalui pelatihan breathing exercise sehingga lansia dapat mengontrol tekanan darah. Kegiatan pengabdian masyarakat ini dilakukan pada Hari Selasa, tanggal 26 Desember 2023 yang bertempat di Padukuhan Ngaran, Balecatur. Waktu pelaksanaan kegiatan dimulai pukul 07.30 s/d 10.00 WIB. Kegiatan ini dihadiri oleh 19 lansia Rt 03, Rw 19 Dusun Ngaran, Balecatur, Gamping, Sleman. Metode yang digunakan dalam kegiatan ini adalah penyuluhan hipertensi dan pelatihan breathing exercise. Hasil kegiatan pengabdian masyarakat ini adalah 63% peserta lansia mengalami hipertensi dan setelah diberikan intervensi berupa penyuluhan penyakit hipertensi dan pelatihan breathing exercise, didapatkan hasil positif terhadap tingkat pemahaman peserta, dibuktikan dengan adanya evaluasi berupa diskusi dan sesi tanya jawab langsung dari responden.
OPERATIVE MONITORING OF LOAD CAPACITY BY EFFICIENCY INDICATOR OBTAINED IN A STANDARD FIELD TEST
Authors: Pokhachevsky Andrey , Vlaskin Dmitriy
Published: February 2024

Monitoring of training work based on efficiency indicators provides individual control of the physiological cost of the performed work. Efficiency indicators are calculated by the MAXIPULSE program based on the results of a standard field test.
THE USE OF COMPUTER GAMES FOR MEDICINE AND SCIENCE
Authors: Bravyy Maksim
Published: February 2024

The aim of the study is to determine the level of awareness of the useful aspects of computer games for disease control research purposes among schoolchildren, teachers and scientists. To do this, a questionnaire was developed and a survey was conducted, in which 67 people participated and which showed that 40% of the participants were aware that computer games could be used in scientific research and disease control. Foldit and Phyllo games are leading the way for use in work and the educational process.
PERFORMANCE EVALUATION APPROACHES IN HIGH LEVEL SPORTS
Authors: Ertan Hayri
Published: February 2024

Muscular activation strategies or recruitment patterns are one of the hot topics in sport sciences. Researchers try to define specific muscular involvement patterns in a given sport branch and during execution of specific movement patterns. As chosen as one of the examples, archery release is very critical to reach high scores in sport archery. Especially, recurve archers use a device called clicker and as soon as its’ snap against the bow handle archer needs to release the string. Three-finger hook opened by active contraction of extensor muscles or just relaxation of forearm flexors. Active contraction of forearm extensor muscles thought to create a lateral deflection of bowstring, which may decrease the score on the target. Like archery, soccer kick is also one of specific movement patterns that have been observed for muscular activation strategies. Lower extremity muscles play an important role in kick movement to stationary ball. Activation of Biceps Femoris and Gastrocnemius muscles found to be different than that of high level soccer players. So, reaching high-level sport performance needs to develop certain muscular activation or recruitment patterns. This review focuses on the specific muscular involvement strategies in given sports.
A STUDY OF THE TECHNICAL ACTIONS OF MIXED MARTIAL ARTS FIGHTERS IN A DUEL
Authors: Pugachev Igor'
Published: February 2024

Based on the media visualization and study of 46 duels of the best mixed martial arts professionals according to the international rating, the differentiation according to the degree of manifestation of the accents of technical actions in the duel was verified. The degree of importance of the elements of the structure of technical action is distributed with the predominance of striking techniques with hands and feet and, to a lesser extent, of throwing techniques.
FACTOR IDENTIFICATION OF THE STRUCTURE OF CONDITION PREPAREDNESS OF MASTERS OF SAILING RACES ON YAL-6
Authors: Pugachev Igor'
Published: February 2024

Factor analysis revealed the parameters that have the greatest communality: running for 1 and 3 km; pull-ups on the bar; lifting a kettlebell; 100 m swimming; 100 m running. Obviously, when three control exercises are included in the program, their communality indicators should be quite high.
BIOMETRIC FLUCTUATIONS OF THE DYNAMICS OF THE PHYSICAL CONDITION OF MASTERS OF SAILING RACES ON YAL-6 UNDER THE INFLUENCE OF PRIVATE TRAINING PRINCIPLES
Authors: Pugachev Igor'
Published: February 2024

On the basis of the professional characteristics of the activities of the masters of sailing races on the Yal-6 and the long-term study of the process of sports training, which ended with the victory at the Russian Championship, five particular principles of training athletes are formulated.
INFORMATION AND COMMUNICATION TECHNOLOGY FOR MANAGING THE COMPETITIVE READINESS OF HIGH-CLASS ATHLETES
Authors: Pugachev Igor'
Published: February 2024

An initial occupational study of physical condition of athletes against the background of the impact of the critical emotional situation of competitions is supposed to determine the tendency of manifestation of human capabilities when the emergency physiological and psychophysiological internal hidden reserves of the body are turned on. Next, a biometric composite prediction criterion is suggested.
APPLICATION OF ARTIFICIAL INTELLIGENCE SYSTEMS FOR RECOGNITION AND EVALUATION OF MOTOR SKILLS AND TECHNIQUES IN HOCKEY
Authors: Yakovlev A.
Published: February 2024

A methodology and tools were developed for recognizing and evaluating the quality of performing techniques and skills in hockey using artificial intelligence methods.
USE OF THE MOBILE APPLICATION "SPORT SELECTION" FOR THE SELECTION AND TRAINING OF YOUNG ATHLETES
Authors: Baranayeu Yury , Mironov Vladimir
Published: February 2024

The result of the research was the development of a mobile application called Sport Selection, which uses an algorithm to compare a child's anthropometric model with the model of elite athletes and provides the result in percentage correspondence.
DIGITAL MECHANISMS FOR ACCOUNTING FOR PHYSICAL ACTIVITY OF THE POPULATION WHO ARE UNPROFESSIONALLY ENGAGED IN SPORTS
Authors: gavrilov nikolai
Published: February 2024

The article discusses digital methods and software mechanisms for accounting for the population who are unprofessionally engaged in sports at urban sports grounds.
AUTOMATED COLLECTION SYSTEM OF BASEBALL MEASURMENT STATISTICS
Authors: Bessonov Roman , Yumatov Boris , Kaverin Alexander , Gutovskaya Natalay
Published: February 2024

The article is devoted to the development of a system for the automated collection of measuring statistics of the baseball games based on measurements of an optoelectronic system, input of information by scorers, and a web site that displays the collected data in the form of interactive tables, graphs and video sequences.
Sloboda bez bratstva
Authors: Harbaš Bernard
Published: February 2024

Theoretical analyses have traditionally related the notion of freedom to politics, law and economy. An individual was perceived free only if he had the right to act politically as equal with other individuals in community. This thesis, which originates from the time of Aristotle, shows that freedom can be understood only in the context of politics. Traditionally, freedom was related to an individual’s economic activities, too. Liberal theorists believed that freedom lies exclusively in the free production and possession of the products of one’s own work. This idea influenced the development of the concept of free market and liberal economy as the foundations of a free society. Hannah Arendt transposed this theory by claiming that freedom must be interpreted beyond any natural necessity and, even more importantly, reciprocity. Following Arendt’s, but also Heidegger’s, line of thought, poststructuralist theoreticians Nancy and Derrida hold that freedom should be interpreted from freedom itself without referring to other experiences of human activity. For Derrida, freedom is breaking up with every conditionality and reciprocity. It cannot be subsumed under the notion of equality but must be understood as the possibility of the other to remain the other in his dissimilarity and secrecy. Key words: freedom, brotherhood, incommensurability, equality, the political.
PENDEKATAN STUDENT CENTERED LEARNING DALAM PENDIDIKAN AGAMA KRISTEN UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA
Authors: Boiliu Fredik
Published: February 2024

Artikel ini bertujuan membahas pendekatan student centered learning dalam pendidikan agama Kristen untuk meningkatkan motivasi belajar siswa. Pendekatan Student Centered Learning dalam pembelajaran yang dimaksud disini adalah proses pembelajaran yang dilakukan haru berpusat pada peserta didik bukan guru.  Metode yang digunakan dalam penelitian ini adalah studi pustaka yakni berisi teori-teori relevan terkait dengan masalah. Hasil penelitian akan menguraikan pendekatan SCL dalam pembelajaran PAK untuk meningkatkan motivasi belajar siswa.
PEMBELAJARAN BERBASIS LINGKUNGAN DALAM PENINGKATAN HASIL BELAJAR PESERTA DIDIK SMPK DON BOSCO ATAMBUA PADA MATERI KLASIFIKASI TUMBUHAN MONOKOTIL DAN DIKOTIL
Authors: Berek Pius A L , Mau Theresia Adelina Maria
Published: February 2024

Outdoor learning is learning through the application of the natural environment as a learning resource that allows students to be able to see, do something, involve themselves in the learning process (undergoing) and experience directly the things being studied. Learning activities will be more meaningful and valuable, because students or students are faced with actual events and situations. Learning is more real, more flexible, and the truth is more accountable. The aim of writing this good practice is to understand the concept of monocot and dicot plant classification after using an environment-based learning method, namely outdoor learning, and to measure whether outdoor learning can improve the learning outcomes of class VII students at Don Bosco Atambua Middle School on the material of monocot and dicot plant classification. The method used in this good practice is the application of outdoor learning to learning. The problem with this good practice is the lack of student learning outcomes in understanding science material, especially biology. The student's score did not reach the KKM set by the school, namely 75. The use of outdoor learning is rarely carried out by biology teachers at SMPK Don Bosco Atambua. Students tend to get bored studying in class. Abstract material concepts and complicated vocabulary regarding the classification of monocot and dicot plants, namely their characteristics. Taproot, fibrous, one and two pieces, parallel veins, pinnate and finger, lack of practical work, low learning motivation and so on. Assessment of student learning outcomes is obtained from evaluation of learning, observations during learning and written interviews with students who are samples in writing this good practice. Analyze data quantitatively and qualitatively by calculating the average student score. The average score obtained by class VII H students before outdoor learning was 55.75, while the score obtained after outdoor learning experienced an increase in learning outcomes with the average score obtained being 95.77 from a total of 34 students. This shows that understanding the material on the classification of monocot and dicot plants using the outdoor learning model is very effective in improving student learning outcomes.
IMPLIKASI INVESTASI PEMERINTAH DAERAH DAN PENINGKATAN POTENSI PAJAK DAERAH KABUPATEN KEPULAUAN SELAYAR
Authors: Aspa  , Ismail Badollahi
Published: February 2024

Investasi merupakan variabel yang sangat penting dalam menggerakan perekonomian suatu wilayah, baik itu dalam lingkup daerah maupun negara. Suatu negara yang mampu mencapai tingkat pertumbuhan ekonomi yang tinggi salah satunya karena ditunjang besarnya aliran investasi ke negara yang bersangkutan. Pertumbuhan ekonomi ditentukan oleh tingginya tabungan dan investasi. Jika tabungan dan investasi masyarakat rendah, maka pertumbuhan ekonomi masyarakat atau negara tersebut juga rendah. Pemda Kabupaten Kepulauan Selayar berinvestasi langsung dalam bentuk penyertaan modal pada Bank Sulselbar, BPR, PDAM dan Perusda. Diharapkan investasi itu bisa memberikan dampak perbaikan ekonomi masyarakat sehingga secara simultan dapat pula meningkatkan pajak daerah. Dengan cara membandingkan data rentang tahun 2019-2022, hasilnya tidak menunjukkan ada dampak pertumbuhan ekonomi demikian pula pada pajak daerah, meski PAD meningkat.
STUDI LITERATUR PENGARUH KINERJA KEUANGAN TERHADAP RETURN SAHAM PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR BURSA EFEK INDONESIA
Authors: Wahyudi Malik
Published: February 2024

Penelitian ini menyajikan hasil dari beberapa studi empiris yang bertujuan untuk mengidentifikasi pengaruh kinerja keuangan terhadap return saham pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI). Dengan Variabel dalam penelitian ini adalah Current Ratio (CR), Return On Assets ROA, Debt to Equity Ratio  (DER), dan Earning Per Share (EPS). Penelitian ini menggunakan metode studi literatur. Data penelititian analitik ini menggunakan data sekunDER dari berbagai sumber akrtikel jurnal yang telah diterbitkan.
A propos de la gestion du timing d’une leçon au groupe scolaire M'famial III le Bambino
Authors: DIGANA  NTETE Benjamin
Published: February 2024

Résumé Le choix porte sur ce sujet a été démontré quand nous posions le problème. Dans une leçon, la gestion du temps est tout a fait une obligation pour tous, vu les bénéfices que cela procure. Ce sujet revêt d'un intérêt capital pour toute société humaine qui veut se développer parce que l'homme doit maximiser son temps pour quantifier la production, c'est pourquoi les anglais disent que « The time is money » et le français : « Le temps c'est de l'or ». Le temps importe quelle tâche pour bien l'accomplir. C'est pourquoi Adelin Nsitu dit que « le temps crée le développement c'est-à-dire que si le temps est bien géré, on peut atteindre les objectifs avec succès (2008, page 5). Mots clés : Gestion du temps, leçons, classe.
Sporda Beyaz Yakalı Çalışanların Örgütsel Sinizm, Örgütsel Adalet ve Örgütsel Muhalefet Düzeylerinin Örgütsel Bağlılığa Etkisi
Authors: TERLEMEZ Murat
Published: February 2024

Bu çalışmanın amacı, spor sektöründe çalışan beyaz yakalıların örgütsel sinizm, örgütsel adalet ve örgütsel muhalefet düzeylerinin örgütsel bağlılığa etkilerinin incelenmesidir. Alan yazın taraması ile başlayan araştırmada elde edilen analiz sonuçları ve bulgulara yer verilmiştir. Spor sektöründe çalışan beyaz yakalıların örgütsel bağlılık düzeylerinin örgütsel sinizm, örgütsel adalet ve örgütsel muhalefet değişkenlerine göre farklılık gösterip göstermediği ve aralarındaki ilişkiler ile örgütsel sinizm ve örgütsel bağlılık arasındaki ilişkinin örgütsel adalet algısı ile modere edilip edilmediği analiz edilip yorumlanmıştır. Analiz neticesinde tüm değişkenlerin normal dağılıma uyduğu gözlemlenmiş olup varsayımlar sağlandıktan sonra ise hiyerarşik regresyon analizi uygulanmıştır. Örgütsel sinizm ve örgütsel adaletin örgütsel bağlılık üzerinde yordayıcı etkisinin analizi ile elde edilen sonuçlar çerçevesinde, örgütsel sinizm düzeyleri ile örgütsel bağlılık düzeyleri arasında negatif doğrusal anlamlı ilişki tespit edilmiştir. Katılımcıların örgütsel adalet düzeyleri ile örgütsel bağlılık düzeyleri arasında pozitif doğrusal anlamlı ilişki bulunduğu, örgütsel muhalefet ile örgütsel bağlılık düzeyleri arasında anlamlı bir ilişki olmadığı da ortaya çıkmıştır. Örgütsel sinizm ve örgütsel adalet düzeyleri arasında da anlamlı bir ilişki tespit edilmiş olup örgütsel sinizm ve örgütsel adaletin birlikte örgütsel bağlılığı anlamlı şekilde yordandığı da görülmüştür. Örgütsel sinizm ile örgütsel bağlılık arasındaki ilişki üzerinde örgütsel adaletin moderatör etkisi analizi ile elde edilen inceleme sonuçlarında ise örgütsel sinizm ve örgütsel adalet modele anlamlı katkı sağlarken ortak etkileşim etkisinin anlamlı bir katkı sağlamadığı ortaya çıkmıştır.
Haematological alterations of mullet Planiliza abu (Heckel, 1843) naturally infected by Ergasilus mosulensis Rahemo, 1982 (Copepoda: Ergaslidae) in a private fish farm from Basrah Province, Iraq
Authors: Al-Daraji Salem , Jabbar Intisar , Jassim Abdul Amer
Published: February 2024

Generally, there is no previous information about haematological parameters of parasitized fish maintained in fish farms in Al- Mashab area, Basrah, Iraq. In this study, the effects of parasitism by the copepod Ergasilus mosulensis. on haemoglobin (Hb), haematocrit (HCT), red blood cells (RBCS), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), and leucocytes were analysed in infected Planiliza abu. The high level of parasitism found in infected fishes was responsible for alterations in blood picture Hb, HCT, RBCS, MCV, MCH, MCHC, and leucocytes (P > 0.05). This is the first report regarding hematology of cultivated freshwater fish which are infected with parasitic copepods in Basrah Province.
Effect of the infection of the mugilid fish Planiliza subviridis with the copepod Ergasilus rostralis: A haematological study
Authors: Al-Daraji Salem , Mhaisen Furhan
Published: February 2024

A total of 83 specimens of Planiliza subviridis were collected from Khor Al-Zubair lagoon, northwest Arab Gulf, Iraq. These fishes were found infected with the copepod Ergasilus rostralis Ho, Javarajan & Radhakrishnan, 1992. Blood parameters: total leukocyte count (WBCs), total red blood cells (RBCs), haemoglobin content (Hb%) and haematocrit volume (PCV) were investigated for lightly (1-5 parasites/fish), mildly (6-10 parasites/fish) and heavily (> 10 parasites/fish) infected fish groups in comparison with uninfected fishes. Uninfected fishes had the highest values of all blood parameters, except WBCs. Hb%, PCV and RBCs significantly decreased in all infected groups when compared with the uninfected group. WBCs significantly increased in all infected fish groups in comparison with the uninfected fishes. WBCs insignificantly decreased in heavily infected group when compared with mildly infected fishes.
Dental unit waterlines and health risks of pathogenic microbial contamination: An update review
Authors: Hikal Wafaa , Kačániova Miroslava , Hussein Diaa Eldin , Ghit Amr , Smaoui Slim , Aleem Muhammad , Čmiková Natália , Said-Al Ahl Hussein
Published: February 2024

Recently, there has been great concern about the levels of oral diseases associated with inappropriate and unsanitary oral care methods. In this line, the most serious is the water contamination with pathogenic microbes. Owing to the water microbial contamination of dental units, patients' oral health is threatened as a result of systemic disorders. Patients receiving treatment in dental unit waterlines were found to be affected by dangerous bacteria. Since both clients and dental staff are exposed to aerosols and water from dental equipment, the water should be of great quality. Due to the fact that dental unit waterlines (DUWLs) create a suitable environment for microbial development and the formation of biofilms, the water is often contaminated with a high density of several microorganisms (e.g., bacteria, fungi, protozoa, viruses), causing a health problem for dentists, patients and elderly patients, especially those with immunocompromised. This has fueled interest in presenting the current situation to shed light on (i) the microbial contamination of DUWLs and (ii) the connected infectious risks. It is essential that an elevated degree of mouth care be combined with adequate water quality and preventive dental units to maintain oral comfort, prevent deterioration, and promote public health. The growing population of individuals with compromised immune systems and the latest technological advancements concerning biofilms, water quality, etc. necessitate the implementation of improved management practices and the application of decontamination protocols for waterlines.
Structural basis for preservation of a subset of Topologically Associating Domains in Interphase Chromosomes upon cohesin depletion
Authors: Jeong Davin , Shi Guang , Li Xin , Thirumalai D.
Published: February 2024

Compartment formation in interphase chromosomes is a result of spatial segregation between eu- and heterochromatin on a few mega base pairs (Mbp) scale. On the sub-Mbp scales, Topologically Associating Domains (TADs) appear as interacting domains along the diagonal in the ensemble averaged Hi-C contact map. Hi-C experiments showed that most of the TADs vanish upon deleting cohesin, while the compartment structure is maintained, and perhaps even enhanced. However, closer inspection of the data reveals that a non-negligible fraction of TADs is preserved (P-TADs) after cohesin loss. Imaging experiments show that, at the single-cell level, TAD-like structures are present
even without cohesin
. To provide a structural basis for these findings, we first used polymer simulations to show that certain TADs with epigenetic switches across their boundaries survive after depletion of loops. More importantly, the three-dimensional structures show that many of the P-TADs have sharp physical boundaries. Informed by the simulations, we analyzed the Hi-C maps (with and without cohesin) in mouse liver and human colorectal carcinoma cell lines, which affirmed that epigenetic switches and physical boundaries (calculated using the predicted 3D structures using the data-driven HIPPS method that uses Hi-C as the input) explain the origin of the P-TADs. Single-cell structures display TAD-like features in the absence of cohesin that are remarkably similar to the findings in imaging experiments. Some P-TADs, with physical boundaries, are relevant to the retention of enhancer-promoter/promoter-promoter interactions. Overall, our study shows that preservation of a subset of TADs upon removing cohesin is a robust phenomenon that is valid across multiple cell lines.
Control of meiotic entry by dual inhibition of a key mitotic transcription factor
Authors: Su Amanda J. , Yendluri Siri C. , Ünal Elçin
Published: February 2024

The mitosis to meiosis transition requires dynamic changes in gene expression, but whether and how the mitotic transcriptional machinery is regulated during this transition is unknown. In budding yeast, SBF and MBF transcription factors initiate the mitotic gene expression program. Here, we report two mechanisms that work together to restrict SBF activity during meiotic entry: repression of the SBF-specific Swi4 subunit through LUTI-based regulation and inhibition of SBF by Whi5, a functional homolog of the Rb tumor suppressor. We find that untimely SBF activation causes downregulation of early meiotic genes and delays meiotic entry. These defects are largely driven by the SBF-target G1 cyclins, which block the interaction between the central meiotic regulator Ime1 and its cofactor Ume6. Our study provides insight into the role of

SWI4
LUTI

in establishing the meiotic transcriptional program and demonstrates how the LUTI-based regulation is integrated into a larger regulatory network to ensure timely SBF activity.SBF subunit Swi4 is downregulated at meiotic entry by the LUTI-based mechanism

SWI4
LUTI

and Whi5 work together to inhibit SBF at meiotic entrySBF and Ime1 TFs antagonize each other, ensuring mutually exclusive cell statesSBF-target G1 cyclins block meiosis by preventing Ime1-Ume6 interaction
Plastic vasomotion entrainment
Authors: Sasaki Daichi , Imai Ken , Ikoma Yoko , Matsui Ko
Published: February 2024

The presence of global synchronization of vasomotion induced by oscillating visual stimuli was identified in the mouse brain. Endogenous autofluorescence was used and the vessel ‘shadow’ was quantified to evaluate the magnitude of the frequency-locked vasomotion. This method allows vasomotion to be easily quantified in non-transgenic wild-type mice using either the wide-field macro-zoom microscopy or the deep-brain fiber photometry methods. Vertical stripes horizontally oscillating at a low temporal frequency (0.25 Hz) were presented to the awake mouse, and oscillatory vasomotion locked to the temporal frequency of the visual stimulation was induced not only in the primary visual cortex but across a wide surface area of the cortex and the cerebellum. The visually induced vasomotion adapted to a wide range of stimulation parameters. Repeated trials of the visual stimulus presentations resulted in the plastic entrainment of vasomotion. Horizontally oscillating visual stimulus is known to induce horizontal optokinetic response (HOKR). The amplitude of the eye movement is known to increase with repeated training sessions, and the flocculus region of the cerebellum is known to be essential for this learning to occur. Here, we show a strong correlation between the average HOKR performance gain and the vasomotion entrainment magnitude in the cerebellar flocculus. Therefore, the plasticity of vasomotion and neuronal circuits appeared to occur in parallel. Efficient energy delivery by the entrained vasomotion may contribute to meeting the energy demand for increased coordinated neuronal activity and the subsequent neuronal circuit reorganization.
Future movement plans interact in sequential arm movements
Authors: Kashefi Mehrdad , Reschechtko Sasha , Ariani Giacomo , Shahbazi Mahdiyar , Tan Alice , Diedrichsen Jörn , Pruszynski J Andrew
Published: February 2024

Real-world actions often comprise a series of movements that cannot be entirely planned before initiation. When these actions are executed rapidly, the planning of multiple future movements needs to occur simultaneously with the ongoing action. How the brain solves this task remains unknown. Here, we address this question with a new sequential arm reaching paradigm that manipulates how many future reaches are available for planning while controlling execution of the ongoing reach. We show that participants plan at least two future reaches simultaneously with an ongoing reach. Further, the planning processes of the two future reaches are not independent of one another. Evidence that the planning processes interact is twofold. First, correcting for a visual perturbation of the ongoing reach target is slower when more future reaches are planned. Second, the curvature of the current reach is modified based on the next reach only when their planning processes temporally overlap. These interactions between future planning processes may enable smooth production of sequential actions by linking individual segments of a long sequence at the level of motor planning.
By-passing the National Level? Municipalities as Legal Actors in Multi-Level Governance in Norway and Sweden
Authors: Stokstad Sigrid , Wenander Henrik
Published: February 2024

This article aims at illuminating the role of Swedish and Norwegian municipalities as legal actors in multi-level governance. The research question is threefold: What is the role of Swedish and Norwegian municipalities as legal actors in relation to the European level? How do these
roles affect local autonomy at the national level? What is the impact of the different affiliations at the European level, Sweden's full membership, and Norway only being a party to the EEA Agreement on these questions? Previous research has shown that municipalities have been able to magnify
their influence, both externally and internally, through the intermediary of the European Union. The ability to magnify their influence will depend on the national constitutional framework and the formal affiliation to the European level, among other things. In this study, the role of the
municipalities in Norway and Sweden is described by analysing the constitutional position of municipalities at the national level, the municipal influence on the drafting of EU legislation, the Nordic municipalities as actors before the ECJ and the EFTA Court and the municipal implementation
of EU/EEA law. On a general level, the study found that the constitutional structures are mainly monolithic, although there are polycentric features. The ability of Norwegian and Swedish municipalities to by-pass national authorities is visible but cannot be described as strong. The role of
the municipalities in acting at the European level is noteworthy, but the legal framework does not allow for a significant increase in local autonomy. The EEA affiliation of Norway implies that the municipalities have a weaker position at the European level.
The Influence of Learning Leadership Competency Model on Teacher Performance
Authors: Singerin Sarlota
Published: February 2024

The introduction underscores the pivotal role of teachers in the Indonesian education system and acknowledges the challenges in achieving high-quality education. This study aims to assess the impact of the Learning Leadership Competency Model, Management Leadership, and Principal Decision-Making Ability on Pedagogical Competency and Teacher Performance, drawing insights from established leadership models and management functions to define the essential competencies for effective teaching. Employing a quantitative approach, the research utilizes Structural Equation Modeling (SEM) on a sample population for hypothesis testing. The section outlines the validity and reliability tests, including the R-Square test to gauge variable influence. Results emphasize the reliability of instruments and provide R-Square values for teacher performance and pedagogical competency. The study's population focuses on the impact of management leadership and principal decision-making ability on pedagogical competency and teacher performance, with a sample size of 100. Hypothesis testing indicates significant positive effects of management leadership, learning leadership competency, and pedagogical competency on teacher performance. The conclusion asserts that while decision-making ability doesn't directly impact teacher performance, it significantly influences pedagogical competency. Both management leadership and learning leadership competency exhibit positive effects on teacher performance and pedagogical competency. Notably, pedagogical competency emerges as a key factor influencing teacher performance.
Response of Mustard (Brassica juncea L.) to Different Bio-Regulators under Varying Fertility Levels
Authors: Damor R. P. , Patel D. M. , Chaudhari A. H. , Patel J. J. , Ganvit V.C.
Published: February 2024

A field experiment on “Response of mustard (Brassica juncea L.) to different bio-regulators under varying fertility levels” was carried out at Agronomy Instructional Farm, Chimanbhai Patel College of Agriculture, S. D. Agricultural University, Sardarkrushinagar during rabi 2017-18. With regard to the effect of different bio-regulators on mustard, all growth attributes studied during the course of investigation such as dry matter accumulation per plant, number of primary branches and secondary branches per plant showed significant improvement due to application of cycocel (CCC) @ 1500 ppm (B3). Whereas significantly the lowest plant height was exhibited under treatment B3. Similarly, treatments B3 (Cycocel @ 1500 ppm) and B1 (Brassinosteroid @ 0.5 ppm) remained comparable and exhibited significantly higher values of yield components and quality parameters viz., number of seeds per siliqua, number of siliquae per plant, test weight, seed yield per plant, protein content and oil yield. Application of cycocel @ 1500 ppm (B3) also significantly increased N and S content in seed and stover and also resulted in significant improvement in uptake of N, P, S and Zn in seed, stover and total uptake followed by treatment B1 (Brassinosteroid @ 0.5 ppm). However, harvest index, phosphorus and zinc content in seed and stover as well as available nutrients status in the soil (N, P2O5, S and Zn) did not influenced due to application of different bio-regulators. Treatment B3 (Cycocel @ 1500 ppm) realized the highest net return (₹ 64,090/ha) followed by treatment   B1 (Brassinosteroid @ 0.5 ppm). The results of the present investigation indicated that all the growth attributes in terms of plant height, number of primary and secondary branches per plant; yield attributes viz., number of seeds per siliqua, number of siliquae per plant, test weight, seed yield per plant, seed, stover yield and quality parameters viz., oil content, oil yield and  protein content showed significant improvement due to application of balanced fertilization treatment N4 (N50P50S40Zn1.7), though it was at par with treatment N3 (N50P50S40). Application of N50P50S40Zn1.7 (N4) registered significantly higher N, P2O5, S and Zn content (%) in seed and stover and seed, stover and total uptake by mustard followed by treatment N3 (N50P50S40). Similarly, application of N50P50S40Zn1.7 (N4) noted significantly higher available N (180.38 kg/ha), P2O5(39.68 kg/ha), S (8.49 mg/kg) and Zn (0.46 mg/kg), being at par with treatment N3 (N50P50S40) except available Zn status in soil. From economic point of view, the maximum net return (₹ 64,897/ha) and benefit cost ratio (3.13) were received with application of 50 kg N + 50 kg P2O5+ 40 kg S + 1.7 kg Zn/ha (N4) followed by treatment N3 (N50P50S40).
Emergency Surgical Management of Thoracic and Limb Injuries in a Hare (Lepus nigricollis)
Authors: Kumar Gaurav , Arora Neeraj , Tiwari Deepak Kumar , Sharma Satbir
Published: February 2024

A one-month old hare (Lepus nigricollis) was brought to the department in emergency with a complaint of dog bite two hours ago due to long chase with dog. Animal was unconscious due to numerous wounds on the thorax and limbs. On clinical examination, fast heart beats were measured from the thoracic perforation at 5th intercostal space and an open wound at the hock joint with abrasions was visible on right hind limb. The animal was handled with appropriate care and after stabilization of vital parameters, surgical management was undertaken under general anaesthesia. The animal showed marked improvement and recovered uneventfully on the 10th  post-operative day.
Hoechst 33258 as a pH‐Sensitive Probe to Study the Interaction of Amine Oxide Surfactants with DNA
Authors: Goracci Laura , Germani Raimondo , Savelli Gianfranco , Bassani Dario M.
Published: November 2004

The use of Hoechst 33258 (HO) as a fluorescent probe to characterize the interactions between DNA and pH‐sensitive amphiphiles is discussed. In the case of amine oxide amphiphiles dodecyldimethylamine oxide (DDAO) and p‐dodecyloxybenzyldimethylamine oxide (pDoAO), the decrease in fluorescence emission, which signals DNA–amphiphile association, is accompanied by a large hypsochromic shift in the emission maximum of the bound probe; this eventually reaches a value characteristic of HO in a neutral or slightly basic environment. These findings are compared to results obtained by using the more common ethidium bromide (EB) probe, which shows no such shift. Circular dichroism and fluorescence depolarization experiments indicate that fluorescence emission only occurs from the DNA‐bound probe, and the observed shift in emission maximum when using HO as a fluorescent probe is due to a variation in the local pH in the vicinity of the probe.
On the Electronic Structure of Ethidium
Authors: Luedtke Nathan W. , Liu Qi , Tor Yitzhak
Published: November 2004

The electronic structure of the common intercalating agent ethidium bromide (3,8‐diamino‐5‐ethyl‐6‐phenylphenanthridinium bromide) is dominated by an interplay of electron donating and withdrawing effects mediated by its nitrogen atoms. X‐ray crystallography, UV/Vis and IR absorption, fluorescence emission, and NMR spectroscopy are used to probe the electronic properties of the phenanthridinium “core” of ethidium as well as its exocyclic amines and 6‐phenyl groups. Interestingly, despite its positive charge, most of ethidium's aromatic carbon and hydrogen atoms have high electron densities (compared to both 6‐phenylphenanthridine and benzene). The data suggest that electron donation by ethidium's exocyclic amines dominates over the electron withdrawing effects of its endocyclic iminium in their combined influence on the electron densities of these atoms. Ethidium's nitrogen atoms are, conversely, electron deficient where the 5‐position is the most electropositive, followed by the 3‐amino, and lastly the 8‐amino group. These results have been used to generate an empirically‐based π‐electron density map of ethidium that may prove useful to understanding its nucleic acid binding specificity.
Dimeric Palladium Complexes with Bridging Aryl Groups: When are they Stable?
Authors: Albéniz Ana C. , Espinet Pablo , López‐Cimas Oscar , Martín‐Ruiz Blanca
Published: November 2004

Stable dimeric palladium(II) complexes of general formula [Pd2(μ‐R)2(η3‐allyl)2] (R=haloaryl, mesityl) have been prepared. Their X‐ray crystal structures, determined for some of the complexes, show that the two coordination square planes are usually coplanar. The haloaryl complexes are fluxional in solution, showing exchange between cis and trans isomers (relative to the orientation of the two allyl groups in the dimer) through solvent‐assisted associative bridge splitting. A number of other ancillary ligands (O,O, S,S, or C,N donors) failed to stabilize the bridging situation. Also, bridging phenyls were unstable. The reasons for this behavior and the formation of alternative compounds in attempts at synthesizing them are fully analyzed and explained. Stable aryl bridges seem to be favored by a combination of factors: the use of ancillary ligands of small size and lacking electron lone pairs, and the use of aryl ligands reluctant to homo and hetero CC coupling. These seem to be more important factors in the stabilization of bridging aryl complexes than the strength of the bridges themselves.
“Bent Bonds” between Bismuth and Carbon Atoms as a Result of CH Activation in MoBi Complexes
Authors: Roggan Stefan , Schnakenburg Gregor , Limberg Christian , Sandhöfner Steffen , Pritzkow Hans , Ziemer Burkhard
Published: November 2004

The reaction of molybdocenedihydride with two equivalents of [Bi(OtBu)3] proceeds via alcohol elimination and provides the compound [Cp2Mo{Bi(OtBu)2}2] (1), which contains two MoBi metal bonds, in good yields. If the two reagents are employed in a 1:1 ratio continuative condensation reactions occur. These initially lead to [{Cp2Mo}2{μ‐Bi(OtBu)}2] (2), which, however, is very unstable in solution and decomposes via additional alcohol elimination: Complex‐induced proximity effects facilitate the cleavage of CH bonds within the cyclopentadienyl ligands by the residual alkoxide ligands, so that spontaneously two further equivalents of alcohol are released, thereby yielding two isomeric compounds 3 and 4 with Cp ligands bridging MoBi metal bonds: The first isomer (3) contains two μ2‐η5:η1‐C5H4 ligands, the second isomer (4) contains one bridging μ3‐η5:η1:η1‐C5H3 ligand. The binding of these ligands to molybdenum and bismuth atoms at the same time is made possible through “bent bonds” between the bismuth and certain carbon centres. These unusual bonding situations were analysed by means of calculations based on density functional theory (DFT), the atoms in molecules (AIM) theory, natural bond order (NBO) considerations and the electron localisation function (ELF). According to the results the bonds can be understood in terms of carbanionic centres interacting with bismuth cations (i.e. closed‐shell interactions). The formation of these bonds and the thermodynamics/kinetics involved on going from 2 to 3 and 4 were also studied by theoretical methods, so that the product formation is rationalised. The crystal structures of all four new compounds were determined. These structures but also the properties and mechanisms of formation are discussed against the background of the corresponding results obtained while studying the system [MeCp2MoH2]/[Bi(OtBu)3].
Aufarbeitung von Elektronikschrott durch Nassoxidation
Authors: Ciesielczuk T. , Oleksowicz S. , Polednia E. , Duda J. , Kotowski W. , Armbruster U. , Martin A. , Lücke B.
Published: November 2004

No abstracts.
Minimaler Energiebedarf von Trennwandkolonnen
Authors: Poth N. , Stichlmair J. , Brusis D.
Published: November 2004

No abstracts.
Rührkesselreaktoren im mL‐Maßstab: Kultivierung von Escherichia coli
Authors: Puskeiler R. , Weuster‐Botz D.
Published: November 2004

No abstracts.
Einfluss der Absorption von Ammoniak auf die Form schwingender Wasserstrahlen in Anwesenheit von n‐Pentanol
Authors: Jatzkowski T. , Modigell M.
Published: November 2004

No abstracts.
Modellierung der Filtrations‐ und Konsolidierungsdynamik von geflockten und nicht geflockten feinstdispersen Kalksteinsuspensionen
Authors: Mladenchev T. , Tomas J.
Published: November 2004

No abstracts.
Unterstützung der Modellierung und Analyse von kontinuierlichen Kristallisationsprozessen mit Fortsetzungswerkzeugen
Authors: Grosch R. , Briesen H. , Marquardt W.
Published: November 2004

No abstracts.
Enlarged and prominent nucleoli may be indicative of MYCN amplification
Authors: Kobayashi Chie , Monforte‐Munoz Hector L. , Gerbing Robert B. , Stram Daniel O. , Matthay Katherine K. , Lukens John N. , Seeger Robert C. , Shimada Hiroyuki
Published: November 2004

BACKGROUND

According to the International Neuroblastoma Pathology Classification, neuroblastomas exhibiting MYCN amplification (A‐MYCN) have unique histologic features—namely, undifferentiated/poorly differentiated subtype with a high mitosis‐karyorrhexis index (U/PD‐H). Nonetheless, certain tumors possessing these histologic characteristics contain a nonamplified MYCN gene (NA‐MYCN).

METHODS

The clinical characteristics of patients from the Children's Cancer Group (CCG) 3881 and 3891 studies who had neuroblastoma, U/PD‐H, exhibiting A‐MYCN (n = 68) or NA‐MYCN (n = 33) were investigated. The histologic and cytologic features of tumors (A‐MYCN, n = 62; NA‐MYCN, n = 28) filed at the Pathology Reference Laboratory, Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles, were reviewed, and nucleolar areas in undifferentiated neuroblastic cells were evaluated using image analysis methods.

RESULTS

All 68 patients whose tumors exhibited A‐MYCN had disease that was in an advanced clinical stage (Stage III or IV); 89.7% of these patients were diagnosed between ages 0.5 and 3.5 years, and 67 of the 68 had been treated with the high‐risk protocol in the CCG‐3891 study. Children whose tumors exhibited NA‐MYCN were evenly distributed across all age groups; 30 of these 33 children had advanced‐stage disease, and 26 had been treated with a high‐risk protocol. The prognosis associated with A‐MYCN (event free survival [EFS], 15.7%; overall survival [OS], 22.2%) was significantly poorer than the prognosis associated with NA‐MYCN (EFS, 56.1%; OS, 69.3%). The lone histologic/cytologic difference between tumors exhibiting A‐MYCN and tumors exhibiting NA‐MYCN involved nucleolar appearance. Neuroblastic cells in tumors exhibiting A‐MYCN were characterized by the presence of 1 or more large, prominent nucleoli, and the mean nucleolar area was significantly greater in the 18 tumors exhibiting A‐MYCN that were assessed (7.63 μm2) than in the 16 tumors exhibiting NA‐MYCN that were assessed (5.53 μm2; P = 0.004).

CONCLUSIONS

Neuroblastomas, U/PD‐H, were found to vary in terms of molecular background and clinical behavior. The results of the current study indicate that nucleolar enlargement in neuroblastic cells may be a sign of MYCN amplification. Cancer 2005. © 2004 American Cancer Society.