bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Indoor Particulate Matter Emissions in Civil Engineering Laboratories
Authors: Zumrut Irem Bayram , Kale Ozge Akboga , Tetik Yilmaz Ogunc , Baradan Selim
Published: December 2022

In the departments of civil engineering, many experiments are conducted in laboratories for educational and research purposes. Varying degrees of respirable dust is generated as the outcome of these experiments which could cause harm to instructors’ and students’ health. This study is devised to highlight the importance of indoor air quality in university laboratories. As part of the research, four different particulate matter (PM) sizes (PM1.0, PM2.5, PM4.0, and PM10) were measured during specific experiments—sieve analysis, preparation of concrete mixture, crushing aggregate by jaw crusher, dynamic triaxial compression test, sieve analysis of silt specimen, cleaning sieve by air compressor and proctor compaction test—being conducted periodically in the laboratories of civil engineering departments. The measured values are mainly high compared to the indoor air quality standards. Recommendations are suggested to reduce indoor air PM levels and control measures were applied to the three experiments which contain the highest PM levels. The results have shown that control measures could make a remarkable difference to protect the instructors and civil engineering students.
An Improved Approximation of Interval Specific Estimates of Parameters for Biological Growth Models
Authors: Karim Md Aktar Ul , Bhowmick Amiya Ranjan
Published: December 2022

Biological growth curves are used to make predictions about natural growth phenomena and have an excellent record of success in several disciplines. A conventional approach is to treat the growth equations as mechanistic nonlinear models and fit them to real data sets by nonlinear least squares or maximum likelihood method. Bhowmick et al. (2014)'s method explicitly utilized the functional form of growth equations and obtained interval-specific estimates of parameters. These estimates have been found to perform better in estimating relative growth rate (RGR) and have the potential for selecting the best model from a set of competitive nonlinear models. Indeed the model-specific estimates of RGR have already been used in growth studies for model selection purposes. However, its computation involves a lengthy mathematical calculation, and many times explicit expressions for the interval-specific estimators are not available that are a function of data alone. For highly nonlinear models, where the parameters are non-linearly related, the computation of interval estimates is almost impossible and may suffer from significant approximation errors. We propose a computational approach to obtain interval estimates of parameters based on the maximum likelihood estimation method. The likelihood function is maximized using the data on smaller intervals. We found that the proposed strategy provides stable estimates compared to an existing approach involving several steps of mathematical calculations. It is also found to be robust when the process error has a significant variance. In addition, it does not require manual mathematical manipulation, instead, it uses available optimizers in software packages efficiently, therefore, giving more accessibility to the practitioners. The validity of the proposed estimation process has been carried out by both simulation studies and real data sets.
Effectiveness of keratinized mucosa augmentation procedures around dental implants based on risk assessment: a 5-year retrospective cohort study
Authors: Wang Jing , Xie Chao , Wei Hong-bo , Yu Zhuo , Li De-Hua
Published: December 2022

Objectives: Evidence on the decision-making of keratinized mucosa (KM) augmentation procedures around dental implants is lacking. The aim of this study was to evaluate the effectiveness of KM augmentation with different techniques around dental implants based on risk assessment.
Materials and methods: Thirty-nine patients who underwent KM augmentation at implant sites in the posterior mandible were included. Three different techniques were used based on risk assessment: apically positioned flap (APF alone), apically positioned flap plus free gingival graft (APF plus FGG), and apically positioned flap plus collagen matrix (APF plus CM). Keratinized mucosa width (KMW), implant/prosthesis survival rates, and bone/soft tissue parameters were analyzed. The correlation between local anatomy characteristics and different techniques was tested separately. The association between KM augmentation outcomes and related factors was analyzed using linear model.
Results: In overall, 74 sites received KM augmentation in the lower jaw, with an effective rate of 94.6% in 1-year follow-up and 93.2% in 5-year follow-up.KMW for APF plus FGG group (3.85±1.22 mm) appeared to be higher than those for APF alone group (3.05±0.90 mm) and APF plus CM group (3.21±1.17 mm) after 5 years. There was no significant difference on the effective/ineffective outcomes in 1-year and 5-year follow-up among the three groups.
Conclusions: Comparable effective outcomes would be achieved with three different KM augmentation techniques following the decision-making criterion based on risk assessment.
Study registration: Chinese Clinical Trial Registry (ChiCTR2200062113)
Clinical Relevance
Scientific rationale for study: The clinical effectiveness of KM augmentation procedures around implants has been documented. However, limited studies reported detailed anatomical characteristics and evidence on the decision-making of KM augmentation procedures around dental implants is lacking.
Principal findings: APF plus FGG could achieve more KW than APF alone and APF plus CM, though there was no significant difference on the effective/ineffective outcomes in 5-year follow-up.
Practical implications:Risk assessment according to anatomical characteristics is necessary before the KM augmentation surgery. Comparable effective outcomes can be achieved with different KM augmentation techniques following the decision-making criterion based on risk assessment.
Parinaud’s syndrome caused by a cerebral infarction in a Covid positive child secondary to diabetic ketoacidosis
Authors: Khalatyan Garik , Boschi Antonella , Duprez Thierry , Coutel Maëlle , de Clety Stéphan Clément , Nassogne Marie-Cécile
Published: December 2022

Cerebral infarction is a very rare complication of diabetic ketoacidosis (DKA) which is a
metabolic disorder caused by insulin deficiency. A previously healthy 6-year-old boy with a
newly diagnosed Type 1 diabetes mellitus presented with a severe DKA. The patient, who
tested positive for SARS-CoC-2 nasopharyngeal PCR, developed about 72 hours after
admission a Parinaud’s syndrome (PS), also known as dorsal midbrain syndrome, which is
described as an up-gaze saccadic paresis, a convergence-retraction nystagmus, a light-near
dissociation of the pupils and occasionally a lid retraction. The brain magnetic resonance
imaging revealed an ischemic infarction in the left thalamus and the thalamo-mesencephalic
junction with a slight extension in the midbrain tegmentum. His symptoms improved
gradually and at 3-weeks follow-up he had a full neuro-ophthalmological recovery.
By describing a Parinaud syndrome as a neuro-ophthalmologic complication in
diabetic ketoacidosis (DKA) crisis, which, to our best knowledge, has not been described yet,
our case expands the knowledge of the neurological manifestations occurring in
children during diabetic ketoacidosis and reiterates the importance to keep those patients
under strict neurological monitoring for at least 72 hours, especially in severe DKA and to
request early brain imaging for any child with neurological deterioration.
Perception of women survivors of sexual violence regarding sexual and reproductive health in conflict settings, eastern Democratic Republic of Congo
Authors: Kimoni Glorieux Bikyeombe , Martin Ravonna , Mukengere Denis Mukwege , Ntamwenge Sifa Naweza , Kerchove Cathleen , Goelz Audrey C
Published: December 2022

Background
Survivors have a particular understanding of sexual and reproductive health issues. The armed conflict in the Democratic Republic of Congo (DRC) is known for the increased use of rape as a weapon of war. This study analyzes sexual and reproductive health issues among survivors of sexual violence in conflict settings in the DRC.
Methods
The study is qualitative analysis of those affected over 10 days. The study population consisted of 61 survivors of sexual violence including adolescents aged 10 to 19 and females aged 20 to 40. 6 adolescent girls and 55 young women survivors receiving psychosocial follow-up were part of the study. Information was collected using 4 focus groups conducted at two sites in the South Kivu region (Kavumu and Bunyakiri). Discussions were transcribed into a composition book and analyzed according to context.
Results
Methods to avoid pregnancy are generally unknown in the adolescent cohort. The girls were unaware of the consequences of unprotected sex, or HIV and AIDS. The more mature women, for their part, unanimously refute the practice of voluntary termination of pregnancy. They are aware of the efficacy of contraception though it is not in common use. Early marriage is not condoned by them.
Conclusion
The psychosocial and medical impact of conflict-related sexual violence can provide a better understanding of how the experience of such an act may affect survivors' perceptions of sexual and reproductive health.
Expression and localisation of MUC1 modified with sialylated core-2 O-glycans in mucoepidermoid carcinoma
Authors: Sugiura Takanori , Hashimoto Kazuhiko , Kikuta Kazutaka , Anazawa Ukei , Nomura Takeshi , Kameyama Akihiko
Published: December 2022

Mucoepidermoid carcinoma (MEC) is the most frequent of the rare salivary gland malignancies. We previously reported high expression of Mucin 1 (MUC1) modified with sialylated core-2 O-glycans in MEC by using tissue homogenates. In this study, we characterised glycan structures of MEC and identified the localisation of cells expressing these distinctive glycans on MUC1. Mucins were extracted from the frozen tissues of three patients with MEC, and normal salivary glands (NSGs) were extracted from seven patients, separated by supported molecular matrix electrophoresis (SMME) and the membranes stained with various lectins. In addition, formalin-fixed, paraffin-embedded sections from three patients with MEC were subjected to immunohistochemistry (IHC) with various monoclonal antibodies and analysed for C2GnT-1 expression by in situ hybridisation (ISH). Lectin blotting of the SMME membranes revealed that glycans on MUC1 from MEC samples contained α2,3-linked sialic acid. In IHC, MUC1 was diffusely detected at MEC-affected regions but was specifically detected at apical membranes in NSGs. ISH showed that C2GnT-1 was expressed at the MUC1-positive in MEC-affected regions but not in the NSG. Conclusion: MEC cells produced MUC1 modified with α2,3-linked sialic acid-containing core 2 O-glycans. MUC1 containing these glycans deserves further study as a new potential diagnostic marker of MEC. (200 words)
Confirmed COVID-19 in a Patient with Pre-Existing Pulmonary Tuberculosis: A Case Report
Authors: Bereda Gudisa
Published: December 2022

Co-infection with COVID-19 and TB frequently results in fever, coughing, hypotension, a changed blood cell count, raised liver enzymes, and decreased hemoglobin. On May 19, 2022, a retired black African woman in her 59s arrived at the emergency room with a tuberculosis diagnosis. She had no recent travel history and was COVID-19-infected. Five days prior to her admission, her sons, who worked in the medical field, were found to be infected with the COVID-19 infection. The patient arrived at the emergency room with weak muscles, a fever, a productive cough, a sore throat, a lack of appetite, a headache, night sweats, and shortness of breath that had lasted for a day. On chest auscultation, there were reduced breath sounds in the right middle and upper lungs. A Mycobacterium tuberculosis infection without rifampicin resistance was detected in a sputum sample using the GeneXpert Mycobacterium tuberculosis and rifampicin tests. After 36 hours, a throat swab polymerase chain reaction test produced positive findings, confirming the presence of the COVID-19 infection. The patient required continuous oxygen at a rate of four liters per minute via a nasal cannula for the first five days while in the hospital, and she is still taking her anti-tubercular medications. In order to combat hospital-acquired infections, she was given therapy with broad-spectrum antibiotics consisting of 500 mg of azithromycin given once a day for five days and 1 g of intravenous ceftriaxone administered daily for five days.
Am(III) adsorption on aluminum (hydr)oxide minerals: Surface complexation modeling
Authors: Satpathy Anshuman , Hixon Amy E.
Published: December 2022

Americium is a highly radioactive actinide element found in used nuclear fuel. Its adsorption on aluminum (hydr)oxide minerals is important to study for at least two reasons: (i) aluminum (hydr)oxide minerals are ubiquitous in the subsurface environment and (ii) bentonite clays, which are proposed engineered barriers for the geologic disposal of used nuclear fuel, have the same ≡AlOH sites as aluminum (hydr)oxide minerals. Surface complexation modeling is widely used to elucidate the adsorption of heavy metals on mineral surfaces. While americium sorption is understudied, multiple adsorption studies for europium, a chemical analog, are available. In this study we compiled data describing Eu(III) adsorption on three aluminum (hydr)oxide minerals—corundum (α-Al2O3), γ-alumina (γ-Al2O3) and gibbsite (γ-Al(OH)3)—and developed surface complexation models for Am(III) adsorption on these minerals by employing diffuse double layer (DDL) and charge distribution multisite complexation (CD-MUSIC) electrostatic frameworks. For corundum and γ-alumina, two different adsorbed Am(III) species, one each for strong and weak sites, were found to be important regardless of which electrostatic framework was used. The formation constant of the weak site species was almost 10,000 times weaker than the formation constant for the corresponding strong site species. For gibbsite, two different adsorbed Am(III) species formed on the single available site type and were important for the DDL model, whereas the best-fit CD-MUSIC model for Am(III)-gibbsite system required only one Am(III) surface species. The corundum and γ-alumina models were validated using limited Am(III) adsorption data available from the literature. The CD-MUSIC model for corundum and both the DDL and the CD-MUSIC models for γ-alumina predicted the Am(III) adsorption data very well, whereas the DDL model for corundum overpredicted the Am(III) adsorption data. The root mean square of errors of the DDL and CD-MUSIC models developed in this study were smaller than those of previously-published models describing Am(III)-γ-alumina system, indicating the better predictive capacity of our models. Overall, our results suggest that using Eu(III) as an analog for Am(III) is practical approach for predicting Am(III) adsorption onto well-characterized minerals.
How rational is practical decision-making?
Authors: Sakaki Shungo
Published: December 2022

Rationality, the premise of economics, is an ideal behavioral norm. In the real world, however, intertemporal decision-making is based on adaptive or sequentially rational behavioral principles from companies to individual households. It bases on managerial accounting procedures, whereby action plans are formulated and implemented, differences from actual results are recognized, and revisions accumulate over time.
We take the intertemporal decision-making problem of households' consumption/investment planning in this paper. And we compare the validity of rationality and adaptability as decision-making principles.
First, rational decision-making in the optimal growth model leads to a unique path. However, optimal growth planning is unstable on the saddle-point path and can only realize if it assumes rationality leading to perfect foresight.
On the other hand, the growth paths guided by budget-controlled adaptive decision-making are diverse and distributed in the myriad around the optimal growth path. This redundancy creates stability in the management and operation of the plan. Because through the trial-and-error process of planning and actual comparison, we can implement a more advantageous plan while allowing for multiple next-best goals, including the optimal growth path.
Moreover, the numerical results show that the adaptive consumption/investment planning is comparable to the optimal growth plan on a social welfare basis, calculated by accumulating consumption utility, and is practically manageable. For example, paths that exceed 0.9 as a ratio to the optimal growth plan are reachable from the initial planning stage at a ratio of 0.58.
JEL codes: C61, C63, O41
Heavy metals in street dust in Beijing, China: seasonal and spatial variations, pollution characteristics and health risk assessment
Authors: Chen Xinhao , Feng Haiyan , Guan Jian , Yu Xiangnan , Xue Fei , Yang Danyu
Published: December 2022

Street dust samples were collected from industrial, residential, educational, commercial, and park areas in Beijing, China, during spring and winter to investigate the contents of heavy metals (Cr, Ni, Cu, Zn, Pb, As, Cd and Hg) and evaluate the source apportionment and degree of environmental pollution according to the geo-accumulation index, ecological indices, and human health risk assessment. The average contents of eight heavy metals (mg/kg) in spring are as follows: Cr (98.17), Ni (26.38), Cu (67.33), Zn (394.87), Pb (64.39), As (6.32), Cd (0.618), and Hg (0.207). In winter they are Cr (94.54), Ni (26.13), Cu (73.03), Zn (341.73), Pb(73.09), As (7.66), Cd (0.635), and Hg (0.279). The rank order of heavy metals concentrations in functional areas is IA (Industrial area) >CA (Commercial area) >EA (Educational area) >RA(Residential area) >PA (Park area). The source apportionment analysis indicates that heavy metals in the street dust are mainly derived from mixed sources of natural, industrial and traffic-related source (54.64%). Both the geo-accumulation index and potential pollution index shows the pollution levels of different heavy metals in different functional areas: from unpolluted, moderately polluted to heavily polluted. A health risk assessment shows no non-carcinogenic and carcinogenic risk of heavy metals to children and adults. Among the five functional areas, the industrial area has the highest non-carcinogenic and carcinogenic risk compared to that of the others.
Translated consent documents rarely used in non-industry sponsored studies
Authors: Garon Edward , Velez Maria , Glenn Beth , Garcia-Jimenez Maria , Cummings Amy , Lisberg Aaron , Nanez Andrea , Radwan Yazeed , Lind-Lebuffe Jackson , Brodrick Paige , Li Debory , Fernandez-Turizo Maria , Gower Arjan , Lindenbaum Maggie , Hegde Manavi , Brook Jenny , Grogan Tristan , Elashoff David , Teitell Michael
Published: December 2022

Patients from historically underrepresented racial and ethnic groups are enrolled in cancer clinical trials at disproportionately low rates in the United States 1-3. As these patients often have limited English proficiency4-7, we hypothesized that one barrier to their inclusion is the cost to investigators of translating consent documents. To test this hypothesis, we evaluated more than twelve-thousand consent events at a large Cancer Center and assessed whether patients requiring translated consent documents would sign consent documents less frequently in studies lacking industry sponsorship (for which the principal investigator pays translation costs) than for industry sponsored studies (for which this cost is covered by the sponsor). Here, we show that the proportion of consent events for patients with limited English proficiency in studies not sponsored by industry was approximately half of that seen in industry sponsored studies. We also show that among those signing consent documents, the proportion of consent documents translated into the patient’s primary language in studies without industry sponsorship was approximately half of that seen in industry sponsored studies. Our results suggest that the cost of consent document translation in trials not sponsored by industry is a potentially modifiable barrier to the inclusion of patients with limited English proficiency.
Fluorescent in situ hybridization is a deceptive method for screening NRG1 gene rearrangements
Authors: Pu Xiaohong , Li Lin , Ren Shuang , Li Jing , Chen Jun , Fan Xiangshan , Peng Shuangshuang , Fu Yao , Zhang Qing , Ye Qing
Published: December 2022

Background
NRG1 rearrangement has been identified in many tumors and is considered an important treatment target. However, the prevalence of NRG1 fusion is extremely rare, and there are no universal testing algorithms for genetic testing.
Methods
A total of 3008 cases of various kinds of tumors were included in this study. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) were used to screen NTRK translocation and p-HER3 expression. FISH translocation or p-HER3 IHC-positive cases were further subjected to next-generation sequencing (NGS) testing.
Results
No cases were p-HER3 positive by IHC. Twenty-nine cases (0.96%, 29/3008) with NTRK translocation were found by FISH, and there were three different signal types: (A) break-apart signal (three cases) with or without a high copy number of the 3’-end of the gene; (B) low copy number of the 5’-end of the gene with respect to the 3’-end of the gene, with fusion signals (12 cases); and (C) low copy number of the 5’-end of the gene with respect to the 3’-end of the gene, without fusion signals. Through NGS, only eight of the 29 cases were confirmed to carry NRG1 fusion. The FISH type C group was completely consistent with the NGS results. For clinical characteristics, all of these NGS NRG1 fusion tumors were adenocarcinomas, and the majority of these tumors (7/8, 87.5%) were female. In addition to NRG1 fusion-enriched breast cancer and lung cancer, we also found cholangiocarcinoma and colorectal carcinoma with NRG1 fusion.
Conclusions
Although FISH is a deceptive method for screening NRG1 gene rearrangements, signals showed low copy number of the 5’-end of the gene with respect to the 3’-end of the gene, without fusion signals were reliable for NTRK fusions. Because of the high false negativity and high cost of NGS, FISH is still a good method for screening NRG1 fusions across cancers.
J-V Characteristics of Dark Current in Truncated Conical Quantum Dot Infrared Photodetectors (QDIPs)
Authors: Ali Nouran M. , El-Batawy Yasser M.
Published: December 2022

Quantum Dot Infrared Photodetector (QDIP) is one of the promising candidates for infrared photodetection due to its controllable heterojunction bandgap and sensitivity to normal incident radiation. It is expected to be superior to infrared photodetectors of mature technologies such as an HgCdTe or a quantum well infrared photodetector. In the presented paper, we have developed a theoretical model for the dark current in truncated conical QDIP as the truncated conical shaped QD structure is more appropriate to describe the fabricated dots. The dark current model is based on the drift diffusion model solving the main governing Poisson’s and continuity equations. In this model, the carrier mobility is calculated by solving time-dependent Boltzmann transport equation in the photodetector material with embedded truncated conical QDs using finite difference technique. The results of the developed model have been compared with the dark current characteristics with published experimental results of InAs/GaAs truncated QDIP. The effects of QD volume, QD aspect ratio and QD density and the operating temperature on the dark current characteristics have also been investigated.
COVID-19: Mental health consequences and strategies put in place to overcome them from the perspective of young adults experiencing social precarity and substance use in Montreal.
Authors: Lemaire Elise Cournoyer , Bertrand Karine , Aranda Jorge Flores , Batel Charlotte , Goyette Mathieu , Milot David-Martin , Jauffret-Roustide Marie , Wagner Vincent , Loignon Christine
Published: December 2022

This study explores the impact of the pandemic on mental health and the strategies put in place to overcome these challenges, from the perspective of young adults who experience social precarity and PS use in Montreal. This collaborative study used a descriptive qualitative design. Ten semi-directed interviews were conducted with young adults aged 18 to 30 years old who experience social precarity and PS use and were analysed thematically. Results demonstrate that participants experienced increased loneliness, psychological distress, and PS use resulting from the sanitary measures. They demonstrated capacities to rely on personal resources to promote harm reduction, resilience, self-entertainment, emotional and social support. The impacts of COVID-19 on mental health demonstrate the importance of maintaining and increasing psychosocial services’ offer in a pandemic context and to better adapt them to the realities of young adults, while also acknowledging and accounting for their strengths and capacities.
Replacement of Signalized Traffic Network Design with Hamiltonian Roads: Delay? Nevermind
Authors: Eriskin Ekinhan , TURKER Gul Fatma , GUNDUZ Fatih Kursat , Terzi Serdal
Published: December 2022

Signal optimisation is essential in traffic engineering. The traffic light control timings should be set as optimum. However, it is challenging because the traffic network is a non-polynomial problem. In this study, the problem is evaluated from a unique perspective. The primary idea is to remove the crossings of the intersections. A Hamiltonian cycle algorithm has been used to design the network. So, vehicles are only able to join or split. Thus, no control mechanism is needed that delays or interrupts the flow. The suggested algorithm and intersection design were tested on Allsop and Charlesworth's widely used sample network. Findings were compared with the literature in the form of delay calculated using the Highway Capacity Manual 2010 formula. The suggested network’s delay is calculated to be 98.17% and 95.45% less than the original network and recently published study-based delay, respectively. As a result, Hamiltonian roads seem sustainable in time and fuel consumption and could be used for future designs.
A study on spatio-temporal coordination and driving forces of urban land and water resources utilization efficiency in the Yangtze River Economic Belt
Authors: Li Zhenqiang , Guo Jiayao , You Xiaoyue
Published: December 2022

Using panel data from 11 provinces from 2003 to 2017 in the Yangtze River Economic Belt, the study explores the spatio-temporal differentiation characteristics and driving forces of coupling coordination of urban land and water resource utilization efficiency by constructing the coupling coordination model and the spatial econometric model. The results show that (1) in terms of time, the situation of inefficient utilization of urban land and water resources was severe. Spatially, the distribution of utilization efficiency of two resources was consistent with the pattern of regional economic development; (2) the coupling coordination degree of urban land and water resources utilization efficiency was mainly of mild disorder type and transitional type, and was in a gradient decreasing spatial distribution from downstream to midstream to the upstream region; (3) the coupling coordination degree of urban land and water resources utilization efficiency presented significantly positive spatial auto-correlation, but the agglomeration trend was weakening; (4) per capita GDP, employment labor force and fixed assets investment were important driving forces for the coordination development of urban land and water resources, while the role of government and the total population had a negative impact on it, and the driving role of the industrial structure had not yet been played.
A predictive model for ammonium removal in polishing ponds operated in sequential bath mode
Authors: de Morais Carlos Eduardo Pereira , dos Santos Silvânia Lucas , van Haandel Adrianus
Published: December 2022

The magnitude of pH changes in polishing ponds can be predicted by simple stoichiometric rules if the extent of processes affecting this parameter is known. Thus, the objective of this article was to develop a model that predicts pH variation and ammonia desorption in polishing ponds in sequential batches, depending on the rates of processes that affect pH in ponds and to evaluate the influence of temperature and depth on these processes. As the temperature conditions change during the year, for model validation, tests were carried out under two medium temperature conditions (hot period and cold period) and four lakes with depths between 0.2 and 1.0 m. The proposed model is validated by the good correspondence between the simulated and experimentally obtained values for the two temperature conditions and for both periods. For the hot period, the model excelled, presenting a high linear correlation, always with R 2 above 0.90 for all ponds. For the cold period, the lowest R 2 obtained was 0.74 for the four lakes. Thus, the proposed model is suitable to describe the pH variation and ammonia desorption in polishing ponds in sequential batches, at all analyzed depths and under both temperature conditions.
A VINGANÇA EM "NA FESTA DE SÃO LOURENÇO"
Authors: Hata Luli , Mello Luiz Carlos Migliozzi Ferreira de
Published: December 2022

O presente artigo analisa o auto Na Festa de São Lourenço, de José de Anchieta, a partir da semiótica de orientação francesa. A vingança é uma paixão lexicalizada na peça e tem diferentes significações para o europeu e para o índio, a cuja etnia o auto é dirigido. A análise revela que a vingança constitui-se como estratégia para conter a relação belicosa entre tribos Tupinambá, uma vez que ela, a vingança, é o fundamento de sua cosmogonia. A Semiótica das paixões mostra que a vingança caracteriza-se por ser um ato individual, por meio do qual se busca o reequilíbrio passional. Contudo, pelo desenvolvimento deste artigo, fica evidente que o sentimento de reparação da falta acontece em um patamar coletivo daquela sociedade. Dessa forma, não obstante a lexicalização da paixão vingança no enunciado, o que existe no auto Na festa de São Lourenço é a discursivização da paixão da justiça.
O CIÚME NO CONTO “OS DOZE PARAFUSOS”, DE MOREIRA CAMPOS
Authors: Oliveira Gustavo de , Leite Júnior José
Published: December 2022

O presente trabalho tem o objetivo de analisar a paixão do ciúme em um conto do escritor cearense Moreira Campos, intitulado “Os doze parafusos”. Ao analisar como uma paixão aparece discursivizada em um texto específico, mostraremos assim a principal característica da abordagem semiótica de paixões: a sintagmatização destas no discurso. Para tanto, utilizar-nos-emos do aporte teórico de Greimas e Fontanille (1993) e das contribuições da vertente tensiva, a partir de Fontanille (1993, 2015), Fontanille e Zilberberg (2001), Zilberberg (2006, 2011) e Tatit (2010a, 2010b). Ao fim deste percurso de análise, acreditamos poder mostrar não só a “imagem” que Moreira Campos cria do ciúme em seu conto, mas também o quanto as sutilezas do estilo moreiriano, e do discurso literário em geral, estão a serviço da abordagem de paixões.
Recent Advances in Synthetic Strategies of Benzimidazole and its Analogs: A Review
Authors: Singh Himanshu , Kumar Rajnish , Tiwari Prashant , Singh Ayushi
Published: December 2022

It has been established on the basis of reported research that benzimidazoles and their analogs are active scaffolds. Benzimidazole is a benzofused imidazole compound that is present in several marketed molecules with a wide range of uses that established its importance in pharmaceutical sectors and industry. Drugs with a benzimidazole nucleus have unique structural characteristics and an electron-rich environment that allows them to attach to a variety of physiologically significant sites and produce a variety of actions. The development of benzimidazole heterocyclic molecules as antihistaminic (H1-receptor antagonist, for example, bilastine; 5-HT3 antagonist, for example, leri-setron); antimicrobial (antibiotic, for example, ridinilazole); antiulcer (proton pump inhibitor (PPI), for example, ilaprazole); antihypertensive (calcium channel blocker, for example, mibefradil); and drugs used to treat cancer include those that are antiparasitic (specifically anthelmintic, such as fubendazole), antipsychotic (D2 receptor antagonist, such as clopimozide), analgesic (opioid analgesic, such as clonitazene), and phosphodiesterase inhibitor (PDE3 inhibitor, such as adibendan). Due to its broad applications, scientists are continuously enthralled by benzimidazoles and their derivatives to study their chemistry. Several synthesis strategies can prepare benzimidazole or its derivatives and the focus will always be on new, greener, and more economical ways for its synthesis. Among all methods, catalytic cyclization, catalytic coupling, and catalytic reactions are the most used approaches for the synthesis of benzimidazoles and their analogs. The present review entitled various synthetic approaches for synthesizing benzimidazole from 2009 to 2021 and its derivatives, which will be very useful to researchers for developing benzimidazole moieties.
Preliminary Study on Human Adipose Stem Cells Promoting Skin Wound
Healing through Notch Signaling Pathway
Authors: Wang Yi , Dong Mengjie , Zheng Yang , Wang Chao , Ding Xu , Wu Heming , Wu Yunong , Zhang Wei , Song Xiaomeng
Published: December 2022

Background:

Mesenchymal stem cells (MSCs) have been documented as possible candidates for wound healing treatment because their use could reinforce the regenerative capacity of many tissues. Human adipose stem cells (hADSCs) have the advantages of easy access, large quantity and easy operation. They can be fully applied in the treatment of skin wounds.

Objective:

In this study, we aim to explore the roles and potential mechanisms of hADSCs in cutaneous wound healing.

Methods:

hADSCs were obtained from human subcutaneous fat. Adipocytes and osteocytes differentiated from hADSCs were determined by staining with Oil Red O and alkaline phosphatase (ALP), respectively. We assessed the effects of hADSCs and hADSC conditional medium (CM) on wound healing in an injury model of mice. Then, we investigated the biological effects of hADSCs on human keratinocytes HaCAT cells in vitro.

Results:

The results showed that hADSCs could be successfully differentiated into osteogenic and lipogenic cells. hADSCs and hADSCs-CM significantly promote skin wound healing in vivo. hADSCs significantly promoted HaCAT cell proliferation and migration by activating the Notch signaling pathway and activated the AKT signaling pathway by Rps6kb1 kinase in HaCAT cells. In addition, we found that hADSCs-mediated activation of Rps6kb1/AKT signaling was dependent on the Notch signaling pathway.

Conclusion:

We demonstrated that hADSCs can promote skin cell-HaCAT cell proliferation and migration via the Notch pathway, suggesting that hADSCs may provide an alternative therapeutic approach for the treatment of skin injury.
The Evolution of Pancreatic Islet Function in a Diabetic Patient after
Pancreatic Neuroendocrine Neoplasm Surgery: A Case Report
Authors: Zhou Ligang , Wen Song , Pan Junhong , Liu Congying , Yuan Xinlu , Wang Congcong , You Qinghua , Liu Xinjiang
Published: December 2022

Background:

Pancreatic neuroendocrine neoplasms (pNENs) are rare primary tumors
of the pancreas. Although these tumors are heterogeneous and can be classified as functional or
non-functional according to pancreatic endocrine biomarkers, the more prevalent type is non-functional
pNENs with endocrine differentiation but with non-specific symptoms and often late diagnoses.
The treatment option for patients often involves surgical management, but the reported outcomes,
especially on insulin secretion change and the trend of diabetes in these patients, varied to
date. Hence, the purpose of this clinical report is to study the functional change of pancreatic β-
cell corresponding to the mass of tumorectomy of pNEN in a diabetic patient.

Case Presentation:

We reported that a 39-year-old man with diabetes was found complicated with
neuroendocrine neoplasm. He was admitted to the General Surgery of our hospital for further examination
and therapy. The patient received a pancreatectomy + splenectomy + lymphadenectomy
on the pancreatic body and tail. We analyzed the pancreatic mass change and performed Oral Glucose
Tolerance Test (OGTT) before and after the surgery to evaluate the function of the pancreas.

Conclusions:

This case may provide us a reference to predict the extent of islet function loss before
the pancreatectomy, and apply personalized hypoglycemic therapy after surgery in these patients.
Kinerja Modulasi BPSK Modem Software Defined Radio pada DSK TMS320C6713
Authors: Sari Sapriesty Nainy
Published: December 2022

Abstractâ€” Software Defined Radio (SDR) is a signal processing technology that optimizes the use of PC as a device supporting. With the application of SDR in wireless communication system so it will provide possibility and flexibility on manipulating DSP without the need of hardware changes. SDR modems are designed to take advantage of Digital Signal Processor Starter Kit (DSK) TMS320C6713 for baseband signal processing. In the implementation phase, the DSK is programmed directly using Matlab Simulink integration to build a system of modulation and demodulation Binary Phase Shift Keying (BPSK). Sampling frequency 8000 kHz is used with a variety of bit rate of 1 kbps and 2 kbps.
Pengontrolan Nutrisi pada Sistem Tomat Hidroponik Menggunakan Kontroler PID
Authors: Akbar Faizal Beni , Muslim Muhammad Aziz , Purwanto Purwanto
Published: December 2022

â€“ Sistem hidroponik merupakan sebuah metode bercocok tanam modern tanpa menggunakan media tanah melainkan air dengan menekankan pemenuhan kebutuhan nutrisi pada tanaman. Sistem Nutrient Film Technique (NFT) merupakan sistem yang mendukung dimana aliran air sangat dangkal mengandung semua nutrisi terlarut. Pengontrolan nutrisi pada sistem tomat hidroponik diperlukan, karena pertumbuhan tanaman bergantung pada pemberian nutrisi yang ideal. Pemberian nutrisi dapat dilihat dari kadar keasaman (pH) air tomat hidroponikÂ  yang idealnya berkisar antara 5.5 hingga 6.5. Sedangkan, air hidroponik biasanya bersifat basa. Dengan menggunakan kontroler PID, sistem akan menghasilkan error steady state yang kecil dan akan mendapatkan settling time yang cepat. Proses perancangan kontroler PID dengan menggunakan metode Ziegler-Nichols didapatkan parameter PID dengan nilai parameter Kp = 4.26, Ki = 0.1065, dan Kd = 42.6. Dari hasil pengujian kontroler PID didapatkan settling time sebesar 520 detik dan recovery time sebesar 118 detik.Â
A Study on variation of Kimhakgongjeon and making of Singyehujeon
Authors:   Korean Language & Literature, Kim Jin-young
Published: December 2022

The main goal of this paper is to examine in terms of work theory that Singyehujeon was created through the epic variation of Kimhakgongjeon. To this end, the plots and narrative characteristics of Kimhakgongjeon and Singyehujeon, and the principle of the narrative and the correlation between the two works were reviewed. Based on this, the value of the two works and the significance of literary history were pointed out. First, Kimhakgongjeon and Singyehujeon have homogeneity in major plots, but the distinction between the two works has expanded by using auxiliary plots in Singyehujeon. If the former is a single plot that secures the narrative portion through the enlargement of the scene, the latter is a multiple plot that satisfies the narrative portion through pixel borrowing. If the former blocked the variation at the inflection point of the narrative to become a single plot, the latter proceeded with the variation at the inflection point to have the editorial narrative character of the plural plot. Second, through the narrative principles of Kimhakgongjeon and Singyehujeon, the problem of the precedence of creation was confirmed. Kimhakgongjeon is a Korean novel based on the existing narrative. Therefore, the circular narrative worked with centripetal force, so the expansion of the narrative did not occur. On the other hand, Singyehujeon borrowed various existing pixels with the addition of an auxiliary plot, and centrifugal force worked importantly. Therefore, it is understood that Singyehujeon, which adds a commercial character, was created in the simple narrative Kimhakgongjeon. Third, the value of the two works and the significance of literary history are noteworthy. When the two works were built, new-style novels appeared and were competing with classical novels. Then, a modern novel that surpassed these two appeared and tried to find a new way out. It is a group of novel works based on Chuno-narrative that can confirm such changes in detail. In other words, they include “Kimhakgongjeon,” which is woven into a single plot using traditional narratives, “Singyehujeon,” which changed it from a commercial purpose to a stratified plot, and “Tangeumdae,” which was recreated by changing the novel technique based on them. Therefore, it can be seen that they are a useful group of works to track the flow of Korean novel history. In this regard, it is worth noting their novel value and the significance of novel history.
A study on vowel harmony for conjugated form in Wanju dialect: focus on geographical differentiation aspects between southern and northern in Wanju
Authors:   Korean Language & Literature, Jang Seung-ick
Published: December 2022

The purpose of this study is to examine that the vowel harmony for conjugated form in Wanju dialect appears differently in southern and northern regions. Until now, Wanju has been regarded as the same dialect area as Jeonju. However, some studies have mentioned that the Wanju dialect differs geographically. To examine this, this article divides the boundaries between the southern and northern Wanju, and analyzes the data of the elderly at each point. In particular, the vowel harmony pattern that appears in the conjugated forme was analyzed. This is because vowel harmony is the main criterion for dividing the Jeollabuk-do dialect into the southeast and northwest. Therefore, it was considered useful to check the difference between the dialects of the southern and northern Wanju. The vowel harmony patterns of type 1 (when the vowel of the stem is 'a, æ') were different in the southern and northern regions of Wanju. This was generally consistent with the characteristics of the southeastern and northwest regions of Jeollabuk-do, respectively. And, type 2(when the vowel of the stem is 'o, ø') maintained the characteristics of the Jeollabuk-do dialect in both the southern and northern Wanju. In addition, it was interpreted that the vowel harmony of p-irregular verb shows the process of assimilating the vowel harmony pattern of the southern part of Wanju to the northern characteristics.
Uplifting the well-being of teacher candidates through virtual exchange during COVID-19
Authors: Hilliker Shannon , Loranc Barbara , Samarakkody Devindi
Published: December 2022

COVID-19 is a time of adversity for college students. Different universities have taken different measures to uplift student well-being. Virtual exchange was a tool that improved student well-being, relieved distress, and helped students focus on their studies. This virtual exchange that partnered teacher candidates outlines how effective this measure was for the participants during COVID-19. This study explores how virtual exchange impacted the well-being of teacher candidates when their university classes were moved online. The data for this research were obtained from a questionnaire, with qualitative and quantitative components, given to the teacher candidates of two universities at the end of the semester regarding their experience interacting virtually throughout the semester. Interacting with a virtual partner when all the classes moved online when less in-person interaction was available benefited students in uplifting wellbeing in terms of Positive emotions, Engagement, Relationships, Meaning and Purpose, and Accomplishment (PERMA).
Assessing the impact of a virtual short-term study-abroad program on Japanese university students’ global-mindedness
Authors: Deacon Brad , Miles Richard
Published: December 2022

Short-Term Study-Abroad (STSA) programs are popular in Japanese higher education; however, participating students’ experiences are under-researched, particularly in areas outside of second-language acquisition. This study empirically assessed the impact of a six-week study-abroad program with a US university (conducted online as a virtual program due to the COVID-19 pandemic) on sophomore Japanese university students’ Global-Mindedness (GM). This mixed-methods study employed experimental (n=53) and control (n=82) groups to investigate the following research question: What is the impact of a virtual STSA program on the GM of participating students? Quantitative data were collected at three time periods (pretest/posttest/post-posttest) using a modified version of the 30- item, five-factor GM Scale (GMS, see Hett, 1993). Descriptive statistics and two-way ANOVAanalyses revealed a significant increase in the experimental groups’ posttest results, which then returned to similar pretest levels in the post-posttest period. Reflection papers, surveys, and semi-structured interviews informed the qualitative perspective, and findings suggested a need for sustained post-program supportive measures to help maintain students’ GM.
Transcription factors as potential markers of carcinogenic effects of chronic exposure. Review
Authors:   Urals Research Center for Radiation Medicine of FMBA RF, Kodintseva E.A.
Published: December 2022

Chronic human exposure to ionizing radiation causes mainly damage to red bone marrow cells, that primarily affects T-cell part of the immunity. Increased incidence of cancer and cardiovascular diseases in the affected people has been registered during long time. Mechanisms of the late radiation-induced immunity changes have not been sufficiently studied. Pathophysiological mechanisms of late effects of chronic exposure are unknown. The paper reviews the latest information on some transcription factors, among them NF-κB, JNK, Р38 and other, involved in cellular response to ionizing radiation. The main transcription factors, such as STAT3, GATA3, T-BOX, FOXР3, RORС and other, control T-lymphocytes differentiation. Location of some transcription factors and short description of their functions are given in the paper. The latest methods of the transcription factors research have been summarized, their advantages and disadvantages have been analyzed. Radiation effects on cells are mainly realized through stress-adaptive mechanism, this makes difficult to study cells response to ionizing radiation and mechanisms of the effects realization, especially delayed effects. Complex research of intracellular signal pathway in relation to genetic and receptor cells apparatus (Т-lymphocytes, performing regulatory functions, and cells effectors of antitumor immunity) will allow the future researches to find out mechanisms of late effects of ionizing radiation chronic exposure to a human, primarily carcinogenic effects