bluuebunny/crossref_metadata_2025 huggingface dataset:
FORMULASI DAN UJI STABILITAS FISIK GEL ANTIJERAWAT EKSTRAK ETANOL DAUN SURUHAN (Peperomia pellucida L.)
Authors:   Universitas Islam Makassar, Arifin Arfiani , Intan Intan ,   Universitas Islam Makassar, Ida Nur ,   Universitas Islam Makassar
Published: January 2023

Suruhan leaves (Peperomia pellucida L.) are known to be rich in secondary metabolites including alkaloids, flavonoids, saponins, tannins and triterpenoid compounds that have potential as anti-acne so that they can be applied as active ingredients in gel preparations. The purpose of this study was to determine the best base for the formulation of an anti-acne gel preparation of suruhan leaf extract that was physically stable. The research method includes the extraction of suruhan leaves by maceration using 96% ethanol. The gel formulation was designed with variations of carbopol base, HPMC, and Na CMC with a concentration of 2%. Physical stability tests include organoleptic, homogeneity, pH, dispersion, viscosity and adhesion which were carried out before and after accelerated storage using a climatic chamber. The results of this study showed that the gel preparation of the ethanol extract of suruhan leaves using carbopol and HPMC bases produced a physically stable gel based on the results of organoleptic tests, homogeneity, pH, dispersibility, adhesion and viscosity, before and after accelerated storage.
KEPATUHAN PENGAMBILAN ULANG OBAT ANTI HIPERTENSI PASIEN HIPERTENSI RUJUK BALIK DI APOTEK APPO FARMA BANJARMASIN
Authors:   Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Prihandiwati Erna , Susanto Yugo ,   Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Alfian Riza ,   Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Sari Maya ,   Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Rianto Leonov ,   Sekolah Tinggi Ilmu Kesehatan IKIFA
Published: January 2023

Complications of hypertension in the body's organs cause a high mortality rate. Hypertension requires long-term drug therapy so that patients must adhere to treatment. One type of adherence in the treatment of hypertension is adherence to taking drugs from health care facilities so that patients always have the availability of drugs to drink. The purpose of this study was to examine the adherence to taking antihypertensive drugs in patients with hypertension who were referred back at the Appo Farma Pharmacy Banjarmasin. The study used an observational design. Data collection was carried out retrospectively. Data were collected from patient prescriptions for referrals at the Appo Farma Pharmacy Banjarmasin in the period May-June 2022. A total of 123 samples were used in this study. The sampling method used simple random sampling technique. Data on adherence to drug taking was analyzed using the Medication Possession Ratio (MPR) method. The parameters of the MPR calculation results are divided into compliant categories if 80% and non-compliant if less than 80%. The research data is displayed descriptively. The results showed that the measurement of adherence to repeated drug taking with a period of 3 months and 6 months were both dominated by samples with the category of adherence to taking medication again with a total of 103 samples (83.74%). Based on these data, it can be concluded that the samples of hypertensive patients in this study were not all adherence in taking their antihypertensive drugs.
FORMULASI DAN EVALUASI NANO HIDROGEL EKSTRAK DAUN SERUNAI (Chromolaena odorata L.) DENGAN VARIASI KONSENTRASI POLIMER CARBOPOL 980
Authors:   Program Studi Sarjana Farmasi, Fakultas Kesehatan, Universitas Sari Mulia, Nabillah Syafira , Noval Noval ,   Program Studi Sarjana Farmasi, Fakultas Kesehatan, Universitas Sari Mulia, Hidayah Nur ,   Program Studi Sarjana Teknik Industri, Fakultas Sains dan Teknologi, Universitas Sari Mulia
Published: January 2023

Hydrogel is an ideal preparation as a wound dressing because it can provide a cold sensation that can reduce swelling in the wound area. Nanoparticles are particles that have a size of 1-1000 nm. Nanoparticles have the advantage of reducing the particle size and delivering the active substance to the target site. In the manufacture of nanohydrogels it is necessary to have a gelling agent in order to obtain a preparation that meets the requirements. In this study, nanohydrogels were made using Chrysanthemum leaf extract (Chromolaena odorata L.) as the active substance and made with various concentrations of carbopol 980 as a gelling agent. The purpose of this study was to determine the effect of variations in the concentration of carbopol 980 on nanohydrogel preparations of chrysanthemum leaf extract. The method used is Quasi Experimental Design. Simplicia was made into extracts and then made into nano preparations and evaluated. Data were analyzed using One Way Anova and Kruskal-Wallis. The particle size of Formula I nanohydrogel preparation was obtained at 412.9 nm. The results of the evaluation of the preparation showed that the nanohydrogel of chrysanthemum leaf extract with variations in the concentration of carbopol 980 had no effect on homogeneity, but it did affect the pH, viscosity, dispersibility, and adhesion test as shown in the One Way Anova statistical test (p<0.05). From the evaluation results, the ideal formula for nano hydrogel preparations was found in formula I with a carbopol 980 concentration of 0.5%.
ANALISIS KINERJA APOTEK AVICENA MENGGUNAKAN PENDEKATAN BALANCED SCORECARD DENGAN ANALISIS SWOT
Authors:   Fakultas Farmasi, Universitas Setia Budi, Rhomah Eka Hayati , Sunarni Titik , Purwidyaningrum Ika
Published: January 2023

The concept of BSC can be used as performance evaluation tool . The purpose of this study is to analyze the performance of Pharmacy in BSC perspectives and determine the strategic map using SWOT method. This research is non-experimental research with a descriptive design. Performance on the BSC. The results of performance measurements are combined with SWOT analysis to determine the strategy map. The results showed the value of TOR, ROI and Nett Profit Margin have not met the standard. Dispensing time meets the standards; Based on the SWOT analysis, the strategy map prepared prioritizes strengthening perspective of learning and growth to improve the quality of pharmaceutical services so can increase customer and revenue growth.
Pengaruh Motivasi Kerja Terhadap Kinerja Penyuluh Pertanian Lapangan
Authors: Mahulauw Faiz Adiansyahputra , William Thenu Stephen Frans , Siwalette Jeter Donald
Published: January 2023

This study aimed to identify the characteristics of PPL in the Salahutu sub-district and to analyze the effect of work motivation on the performance of agricultural extension workers in the Central Maluku district. The study consisted of 9 variables, namely the Performance of Extension Officers X1 Leadership, X2 Work Environment, X3: Intensive or Operational Costs X4 Work Culture, X5 Communication, X6 Salary, X7 Training, X8 Awards, X9 Age factor, which was analyzed using the Multiple Linear Regression Method with assistance SPSS Version 23.0. The study results show that all of these variables jointly affect the performance of agricultural extension workers (PPL). seven variables have a positive and significant effect on paddy rice production. In contrast, the training and reward variables have a positive and insignificant relationship to the performance of field agricultural extension workers (PPL).
Students' Mathematical Communication Skills Through Learning 4k Models To Improve The Character Of Curiosity
Authors: Saironi Moh , A H Busiri
Published: January 2023

In essence, every human being must always communicate, but the level of breadth of communication will always be different. Communicating that is more meaningful is determined by the level of one's thinking ability. Thinking more creatively and innovatively in dealing with problems and situations will not be possessed without extensive knowledge. The goal of mathematics is that students have the ability to understand mathematical concepts, use reasoning, solve problems, communicate ideas, and have an attitude of appreciating the usefulness of mathematics in life. This study used techniques and methods of systematic literature review or also known as literature review. The method used for data collection techniques is conducting a literature study, then identifying, studying, evaluating, and interpreting the available research, literature books, and reports. As a result of the maximum educational process, teacher activity is needed in choosing learning strategies. The obligation as an educator, is not only to transfer knowledge, but also to change the behavior and character of students and provide positive encouragement, so that students are motivated to provide a pleasant learning atmosphere so that they can develop as much as possible. The conclusion is that the selection of learning strategies to be used in the learning process must be oriented towards the learning objectives to be achieved. In addition, it must be adjusted to the type of material, the characteristics of students, the conditions in which the learning process will take place.
Assessment of endothelial dysfunction and inflammation in type 2 diabetic postmenopausal women
Authors: Abbak Yavuz , Çam Abbak Hilal , Bahtiyar Nurten , Toplan Selmin
Published: January 2023

Objective: Vascular complications in type 2 diabetes mellitus are an important cause of morbidity and mortality. Also, endothelial dysfunction arises with vascular ageing during the postmenopausal period. Our objective in this study was to evaluate inflammation and endothelial function parameters and their possible diagnostic roles in type 2 diabetic postmenopausal patients.
Material and Methods: The study was conducted on four groups, including type 2 diabetic premenopausal (n:20), non-diabetic premenopausal (n:20), type 2 diabetic postmenopausal (n:20), and non-diabetic postmenopausal subjects (n:20). Serum endothelin-1 (ET-1), endothelial nitric oxide synthetase (eNOS), interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), and chitinase-3-like protein 1 (YKL-40) levels were determined as inflammatory and endothelial function markers using ELISA kits.
Results: Serum ET-1, IL-6, and YKL-40 levels were higher in the type 2 diabetic postmenopausal group compared to the non-diabetic premenopausal group (p<0.01, p<0.05, and p<0.01, respectively).  ET-1, IL-6, and YKL-40 levels were higher in the type 2 diabetic postmenopausal group compared to the non-diabetic postmenopausal group (p<0.001, p<0.05, and p<0.01 respectively). ROC analysis revealed serum ET-1 (AUC 0.933, sensitivity 87.5%, specificity 85.7%), IL-6 (AUC 0.812, sensitivity 56.3%, specificity 92.8%), and YKL-40 (AUC 0.880, sensitivity 81.2%, specificity 92.8%), as good diagnostic parameters, especially in the type 2 diabetic premenopausal vs. non-diabetic premenopausal cohorts.
Conclusion: Serum ET-1, IL-6, and YKL-40 levels were at the highest levels in the 2 diabetic postmenopausal group, and the increase in these markers was remarkable in diabetes compared with menopausal periods. Also, ET-1, IL-6, and YKL-40 were good diagnostic parameters for detecting endothelial function and inflammation in type 2 diabetic postmenopausal and non-diabetic premenopausal cohorts.
Persiapan Ujian Nasional (UN) Mata Pelajaran Matematika SMP Negeri 20 Pontianak Utara (Survey tentang Upaya Sekolah, Guru, Orang Tua, dan Siswa dalam Mempersiapkan Siswa Memenuhi Standar Kelulusan UN)
Authors: Pratiwi
Published: January 2023

Tujuan  dalam penelitian ini secara umum adalah untuk mengetahui hubungan dan pengaruh persiapan orang tua siswa dan persiapan siswa secara bersama-sama terhadap hasil UN mata pelajaran Matematika siswa SMP Negeri 20 Pontianak Utara. Metode penelitian yang digunakan dalam penelitian ini adalah metode survey. Penelitian menggunakan teknik komunikasi tidak langsung dan angket sebagai alat pengumpul data pokok. Ada 373 orang yang ditetapkan sebagai populasi dalam penelitian ini, terdiri atas: (1) responden yang menduduki jabatan fungsional pada tingkatan manajemen puncak (top of management level) di sekolah, yaitu Kepala Sekolah, Wakil Kepala Sekolah, Waka Kurikulum, dan Waka Kesiswaan; (2) guru matematika; (3) orang tua siswa (dihitung 1 mewakili sebagai orang tua); dan (4) siswa. Kesimpulan yang didapat diantaranya: (1) Hubungan fungsional antara persiapan orang tua siswa dan siswa SMP Negeri 20 Pontianak Utara dengan hasil UN Matematikanya mempunyai arah positif; (2) Korelasi majemuk persiapan orang tua siswa dan persiapan siswa SMP Negeri 20 Pontianak Utara dengan hasil UN Matematikanya tergolong Sangat Rendah, ditunjukkan dengan r = 0,135, tetapi tidak signifikan.
Upaya Meningkatkan Hasil Belajar Matematika Siswa Melalui Pendekatan Active Learning Tipe Quiz Team Pada Materi Bangun Ruang Kelas VIII-1 Di SMP Negeri 30 Jakarta
Authors: Sara Yuni
Published: January 2023

Penelitian ini bertujuan untuk meningkatkan hasil belajar matematika siswa pada materi bangun ruang sisi datar melalui pendekatan active learning tipe quiz team di kelas   VIII-1 SMP Negeri 30 Jakarta. Metode penelitian yang digunakan adalah Penelitian Tindakan Kelas (PTK) dengan model Kemmis dan Mc Taggart melalui empat tahapan, yaitu: perencanaan, pelaksanaan, pengamatan, dan refleksi. Subjek penelitian adalah siswa kelas VIII-1 SMP Negeri 30 Jakarta tahun pelajaran 2019-2020 yang berjumlah 30 siswa, terdiri dari 11 siswa laki-laki dan 19 siswa perempuan. Penelitian ini dilaksanakan dengan dua siklus. Pada siklus pertama, sebagian siswa belum terbiasa dengan cara pendekatan active learning tipe quiz team. Dalam siklus kedua, siswa memahami pendekatan active learning tipe quiz team dan menunjukkan hasil yang memuaskan. Hasil belajar siswa yang mencapai KKM yaitu 80 pada siklus I yakni mencapai 63,33%, sedangkan pada siklus II terjadi peningkatan mencapai 86,67% dengan nilai rata-rata kelas pada siklus I yaitu 82,4 dan siklus II yaitu 86,5. Hal ini menunjukkan terjadinya peningkatan hasil belajar siswa secara signifikan. Dari hasil observasi aktivitas siswa menunjukkan peningkatan skor rata-rata pada siklus I sebesar 29,5 menjadi 35,25 pada siklus II. Dengan demikian dapat disimpulkan bahwa pendekatan active learning tipe quiz team dapat meningkatkan hasil belajar matematika siswa dengan materi bangun ruang pada siswa kelas VIII-1 SMP Negeri 30 Jakarta.
A responsabilidade penal individual dos delitos econômicos empresariais: uma análise sobre 'o Caso Samarco'
Authors: Oliveira André
Published: January 2023

O artigo apresenta discussões da dogmática penal nacional e estrangeira acerca dos critérios de imputação da responsabilidade penal
individual nos delitos econômicos empresariais, notadamente os conceitos de posição de garante e omissão penalmente relevante. Em seguida, propõe um estudo de caso prático mediante a análise da ação penal promovida pelo Ministério Público Federal no crime ambiental ocorrido em 2015 na cidade de Mariana/MG, popularmente chamado “Caso Samarco”, resultando na morte de diversas pessoas. O uso de conceitos jurídicos de outros ramos do direito possibilita pontuar os deveres legais nos vários níveis de um
contexto empresarial complexo, concluindo-se pela adequação da ação penal proposta no caso concreto.
TAX PLANNING ANALYSIS TO MINIMIZE INCOME TAX PAYMENT PT. “MTH”
Authors: Muti’ah  , Marsyaf  , Bambang Subiyanto
Published: January 2023

This study aims to describe the implementation of Tax Planning, in order to minimize Income Tax payments at PT. MTH. The type of data used is primary and secondary data. The analytical method used is descriptive quantitative and descriptive qualitative. Based on the results of the study it can be concluded that the Tax Planning carried out by PT.” MTH” is not optimal, where there are still company expenses that can be recorded as expenses for obtaining, collecting and maintaining income ( by placing the company logo on employee uniforms as a promotion platform, making a nominative list related to entertainment expenses , phone credit and cell phone repairs for employees because of their position or job, giving natura in the form of allowances) thus the total operational costs in the profit/loss report become larger so that the impact on year-end profits becomes smaller.
KEYWORD: Tax Planning, Efficiency, commercial financial reports
THE STRUCTURE OF A NEURO-FUZZY NETWORK BASED ON BAYESIAN LOGICAL-PROBABILISTIC MODEL
Authors:   Candidate of Technical Sciences, Associate Professor, Emperor Alexander I St. Petersburg State Transport University, Saint Petersburg, Russia, Kozhomberdieva Gulnara I. , Burakov Dmitry P. ,   Candidate of Technical Sciences, Associate Professor, Emperor Alexander I St. Petersburg State Transport University, Saint Petersburg, Russia, Khamchichev Georgii A. ,   Postgraduate Student, Emperor Alexander I St. Petersburg State Transport University, Saint Petersburg, Russia
Published: January 2023

The article presents a multilayer structure of a neurofuzzy network based on the Bayesian logicalprobabilistic model of fuzzy inference, previously proposed, researched and implemented by the authors. A brief description of the Bayesian logicalprobabilistic model is given, an example of setting up a neurofuzzy network for solving a fuzzy inference problem is presented. The example shows which network parameters can be used for its training. According to the authors, the proposed network structure with three parametric layers is comparable to the wellknown Takagi– Sugeno–Kang and Wang–Mendel fuzzy neural networks.
IMPROVING METHODOLOGY FOR ASSESSING THE SOCIAL RESPONSIBILITY OF TRADE ORGANIZATIONS
Authors:   Plekhanov Russian University of Economics, Moscow, Russia, Mayorova Elena A. , Lipatov Nikita S. ,   Plekhanov Russian University of Economics, Moscow, Russia, Sokolov Aleksey S. ,   Plekhanov Russian University of Economics, Moscow, Russia
Published: January 2023

The aggravation of social problems actualized the issues of corporate social responsibility management, including in the field of trade. Effective management of social responsibility involves its assessment. The purpose of the study is to improve the methodological support for assessing the social responsibility of trade organizations. The existing methodological approaches to such an assessment are characterized, its methodology is proposed, which complements the well-known tools and allows analyzing the perception of the social responsibility of trade organizations by stakeholders, taking in to account the significance of its individual parameters. The technique can be used in the practice of trading structures, including network ones.
FEATURES OF THE SELECTION OF PERSONNEL AT THE ENTERPRISE OF CREATIVE ORIENTATION
Authors:   Manufacturing Company «My portrait», Moscow, Russia All-Russian Association of Lawyers of Russia ", Aleeva Anna O. ,   VAYUR",   , Moscow, Russia
Published: January 2023

The article is devoted to identifying the reasons why it is so difficult to assemble a strong and longterm team in creative projects and effectively manage them. The author notes that only those companies whose HR managers are familiar with phased screening methods can do this. It is concluded that following the correct sequence of candidates passing through the selection funnel automatically solves two key problems associated with the management of creative personnel. Analytical work has been carried out to study methodologies for evaluating creative personnel in foreign and Russian companies and an own effective algorithm for passing creative applicants through the HR funnel has been proposed.
IMPROVING THE NATION: PROBLEMS AND SOLUTIONS
Authors:   Vladimir Branch of RANEPA, Vladimir, Russia, Zhambrovsky Sergey V. , Kremlev Umar N. ,   Vladimir Branch of RANEPA, Vladimir, Russia, Novikov Alexander I. ,   Vladimir Branch of RANEPA, Vladimir, Russia, Savelev Igor I. ,   Vladimir State University named after A.G. and N.G. Stoletovs, Vladimir, Russia
Published: January 2023

The issues of improving the health of the nation are considered as a set of actions of state authorities, society and business to protect public health as national wealth, to achieve the social well-being of the nation, its economic and social prosperity. The improvement of the nation is considered as a process of sustainable social and economic development (economic growth, poverty reduction, achievement of social justice), the acquisition of spiritual and moral health, the provision of guarantees for health protection and the achievement of passionate health and energy.
PROBLEMS AND PROSPECTS OF «3 + 3» COOPERATION IN THE SOUTH CAUCASUS
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russia, Karimov Sh. I.
Published: January 2023

The subject of the work is a complex of problems related to the establishment of close and constructive relations between the countries of the South Caucasus and their neighbors – Russia, Turkey, Iran. The specifics of the relations between the Transcaucasian countries and Western countries are touched upon. The circle of geopolitical interests of Western countries (led by the United States) regarding this region is described. Further use is proposed for establishing a mutual dialogue between the countries on the “3 + 3” platform (Russia, Turkey, Iran, Armenia, Azerbaijan and Georgia). The research uses scientific methods: systemic, institutional and statistical. It has been proved that cooperation between the Transcaucasian countries and their geopolitical neighbors is quite productive in the “3 + 3” format. Conclusions are drawn that Western countries are directly interested in spreading influence in the region. However, at the moment they are distracted by the geopolitical agenda related to Russia's special military operation in the Donbas. After resolving this issue, the West will deal with the destabilization of the South Caucasus, which can be prevented by the joint efforts of Russia, Turkey, Iran, Azerbaijan, Armenia and Georgia.
METHODOLOGICAL APPROACHES TO FINANCING INVESTMENT PROJECTS
Authors:   Irkutsk National Research Technical University, Irkutsk, Russia, Nechaev Andrey S. , Badanov Alexey B. ,   Irkutsk National Research Technical University, Irkutsk, Russia
Published: January 2023

The article analyzes the theoretical and methodological aspects of financing investment projects. Based on theoretical approaches to financing, the authors have identified business goals for the implementation of investment projects, which consist in: expanding sales of existing products; developing or acquiring new technical skills and assets; entering new markets or creating new products that meet a certain market need. The business goals of investment projects defined by the authors will allow us to prepare an accurate assessment of the estimated costs associated with the necessary measures for financing projects at enterprises. The analysis of classification methods for alternative investment proposals is carried out, namely; the size of the project; potential benefits from the project; the degree of interdependence between investment projects; the type and timing of receipt of funds. The basic principles of financing investment projects have been identified, which delimit powers, determine the equality of participants in the implementation of projects, influence the attraction of additional financing and concentrate financial resources. The article also reflects the process of financing the organization, which regulates the internal analysis of financial potential. This process is based on the history of cash income, the type of assets and fixed assets, as well as the experience and quality of employees involved in the implementation of the investment project. The problems that investors and creditors may have are identified and recommendations for their elimination are proposed.
The level of copper in the milk of breeding cows in winter and spring
Authors:   Federal Research Center for Animal Husbandry named after Academy Member L. K. Ernst, Dubrovitsy, city of Podolsk, Russian Federation, Voronina Oksana A.
Published: January 2023

As an essential test for all forms of life on earth, copper (Cu) is of great interest and a vast field for research. The inclusion of Cu in the functioning of a group of substances is carried out through amino acids. The scope of action of copper-containing proteins is quite wide. They are involved in the accumulation of blood cells and the functioning of the immune system, include increased lipid content, contraction of the cardiovascular system and body growth. The purpose of this work is to follow the dynamics of the Cu content in milk at the time of the season change and to establish the strength and direction of correlations with the amino acid composition of milk. In total, 88 samples of milk from the Ladoga breeding farm were studied in the work. Direct analysis in the Department of Physiology and Biochemistry of Farm Animals of the Federal Research Center for Animal Husbandry named after Academy Member L. K. Ernst. In January, February, March and May, a random sample of 22 lactating cows was formed from the dairy herd. Milk samples were prepared for Cu analysis using the ETHOS EASY system (Italy), direct analysis was performed on a ZEEnit 650 P atomic absorption spectrometer (Analytik Jena AG). For the analysis of amino acids, an HPFA LC-20 AD Prominence system (Shimadzu, Japan) with an analytical module for post-column derivatization АРМ-1000 (Sevko&Co, Russia) is used. The highest values for Cu were set in March (149,4±7,6 μg/l), the lowest in May (79,9±4,2 μg/l). Significant differences with respect to January were established in May (p˂0,001) and March (p˂0,05). The most significant correlation coefficients in January – threonine, alanine, cysteine, tyrosine, phenylalanine, histidine, lysine; in February – aspartic and glutamic acids, threonine, serine, glycine, alanine, cysteine, valine, isoleucine, leucine, tyrosine, phenylalanine, histidine, lysine, proline; in March – aspartic and glutamic acids, threonine, serine, glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, histidine, arginine.
Express-methods for selective and nonselective determination of indole alkaloids
Authors:   All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, Moscow, Russian Federation, Volnin Andrey A. , Tsybulko Nataliya S. ,   All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, Moscow, Russian Federation, Savin Pavel S. ,   All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, Moscow, Russian Federation, Myasnikova Svetlana B. ,   All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, Moscow, Russian Federation
Published: January 2023

In this work, we have considered the methodological features of the use of non-selective colorimetric determination of total content of indole alkaloids (with van Urk reagent) and qualitative-quantitative selective determination of the alkaloid composition by thin-layer chromatography (TLC) with densitometric scanning of chromatograms for related to cultivation a live collection of parasitic strains of Claviceps purpurea. The total content of ergoalkaloids, as well as the content of the target ergoalkaloid, was determined in 4 strains: for VKM F-3602 D, producent of ergocryptine, total content of alkaloids was 0,42±0,02 g/100 g with the content of α-ergocriptine from 71 to 79 %, for VKM F-2641 D ergotamine producent total content of alkaloids was 0,56±0,03 g/100 g with ergotamine content from 43 to 67 %, for VKM F-3410 D ergocristine producent total content of alkaloids was 0,42±0,02 g/100 g with an ergocristine content of 62 to 89 %, for A- 144 ergocristine producent, the amount of alkaloids was 0,42±0,04 g/100 g with an ergocristine content of 62 to 75 %. The solvent system methylene chloride: dioxane: ethanol: ammonia in the ratio 36:3:1:0.3 was used for separate of ergoalkaloids.
Morphological changes in nerve fibers in the skin of sheep during melophagosis
Authors:   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin, Moscow, Russian Federation, Baymatov Valery N. , Shakirova Galiya R. ,   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin, Moscow, Russian Federation, Nigmatullin Rustem G. ,   Bashkir Scientific and Production Veterinary Laboratory
Published: January 2023

Experimental infection of sheep with melaphagosis leads to significant structural damage to the skin and its nerve fibers. Bloodsuckers are mechanically transferred through skin scratching to endothelial cells and tissue settled macrophages from places of microtrauma caused by the piercing- sucking apparatus of the carriers and the runes themselves. Proboscis parasites injure the skin, blood vessels, causing inflammation. A synchrony of local and generalized inflammatory processes is formed, which last for a long time due to the blood-sucking of ectoparasites. Periodic suction of blood is accompanied by injection of saliva and coxal fluid into the capillary, which contain the pathogen, anticoagulants and enzymes. At the site of injury, labrocyte degranulation occurs, a large number of inflammatory mediators are released: histamine, heparin, serotonin, which initiate an inflammatory reaction and pain syndrome. Re-irritation of skin receptors, afferent pathways leads to depletion of metabolites in the nerve fibers, and dystrophic processes develop. The protective reaction at the site of the entrance gate is accompanied by the simultaneous generalization of the recovery process after the treatment of sheep with mediatrin. In the skin, compensatory- adaptive changes are observed in the epithelial sheaths of the hair roots, in the sebaceous glands and the restoration of the structure of the endothelium of the blood capillaries. Significant destructive changes in the structure of collagen and elastic fibers remain in the reticular layer of the dermis. Labrocytes, with a large number of granules, testify to a decrease in the intensity of the inflammatory process in the skin of sheep.
Efficiency of a feed additive based on Leuzea safflower and animal protein obtained from vermiculture
Authors:   Perm State Pharmaceutical Academy, Perm, Russia, Kashina Tatyana A. , Shutova Anastasia A. ,   Perm State Pharmaceutical Academy, Perm, Russia, Solodnikov Sergei Yu. ,   Perm National Research Polytechnic University, Perm, Russia, Malysheva Ksenia O. ,   Perm National Research Polytechnic University, Perm, Russia, Veretennikov Vladislav V. ,   St. Petersburg State University of Veterinary Medicine, St. Petersburg, Russia, Tarlavin Nikolai V. ,   St. Petersburg State University of Veterinary Medicine, St. Petersburg, Russia
Published: January 2023

The article presents the results of studying the effectiveness of the use of a feed additive consisting of Leuzea safflower and vermiculture powder on the protective mechanisms of broiler chickens. In the course of the study, the influence of the use of the feed additive on the increase in live weight, hematological parameters (biochemical and morphological parameters of blood), indicators of acquired and innate immunity of broiler chickens were evaluated. It has been established that when a feed additive is included in the diet of chickens, a significant increase in body weight gain of broiler chickens of the experimental group is observed in comparison with the control group. In the course of assessing the biochemical and immunological status in animals of the experimental group a tendency to an increase in the concentration of immunoglobulins A and M in the blood serum was established. Thus, the use of a new feed additive based on Leuzea safflower accelerates the weight gain of broiler chickens. The results of the study substantiate the feasibility of using a feed additive in the diet of broiler chickens.
Dialogic Interaction and Cyber Democracy: A Study of Twitter Accounts of Pakistani Politicians
Authors: Khurshid Amna , Rawan Bakht
Published: January 2023

Social media use equalizes the power among public and politicians, which promotes cyber democracy. This study explores dialogic interaction between Pakistani politicians and the public by examining Twitter accounts of politicians of major parties i.e., Pakistan Tehreek-e-Insaf (PTI), Pakistan Muslim League (Nawaz) PML (N), and Pakistan People’s Party (PPP) for the year of 2021. It was hypothesized that among dialogic interaction features, it is more likely that conversations of visitors, usefulness of information, and the style of dialogic interaction will be the dominant features as compared to dialogic loop in Twitter accounts of Pakistani politicians. Content analysis was conducted on twitter accounts of Pakistani politicians (two politicians from each party). Total number of tweets during the selected time was 5421 from which 989 tweets were selected for analysis. The result showed that politicians are using usefulness of information followed by a style of dialogic interaction, dialogic loop and conversation of visitors. The results do not support hypothesis as dialogic loop is not least used feature in tweets of Pakistani politicians.
PERFORMANCE EVALUATION OF THE POPULAR SWRC MODELS AT DIFFERENT SOIL BULK DENSITY RANGES
Authors: Too Vitalis , Omuto Christian , Biamah Elijah , Paul Obiero John
Published: January 2023

Soil bulk density is an important soil property which influences the hydraulic properties of soil. Soil bulk density has never been a fixed soil property, but it varies spatially due to soil changes and temporally due to human activities, soil management and effects of climate change. This changes in soil bulk density affects the characterization of hydraulic properties of soil especially when mathematical soil retention models are used. Since the measurement of the soil water retention characteristics in the field is expensive, labor intensive and time consuming, mathematical models have been developed to predict these properties. Therefore, it is important to establish the impact of the soil bulk density on the performance of these mathematical models especially their accuracy to fit measured data using measured data. The aim of this study was performance evaluation of the water retention models at different soil bulk density ranges. The study used the dataset downloaded from the global database (ISRIC). The study used Residual Standard Error (RSE) and R2 to measure the accuracy of the model in predicting or quantify the goodness of fit to the experimental data. The low values of RSE shows that experimental data are close to the model predictions. This paper discussed the popular Soil Water Retention Characteristic (SWRC) models then it assessed their performance on varying soil bulk density ranges. The results from the study showed that the performance of the models improved with increase in values of field bulk density. It was established that Gardner and Bi-exponential models were better suited to describe SWRC irrespective of the variation of soil bulk density because they displayed consistent best performance (R2 greater than 0.98) at low and high soil bulk density. From the study, the soil scientist can choose these models to apply especially when the soil bulk density varies greatily.
DEVELOPMENT OF A PREDICTIVE MAINTENANCE MODEL FOR A CASSAVA PULVERISER
Authors: A.E Oluleye , K.R Ekun
Published: January 2023

Cassava is an important staple crop that serves as a primary food source in Nigeria. Nigeria produces about 20% (60 million tonnes) of the total world cassava production (302.6 million tonnes) of cassava. To process cassava tubers into edible products, machines and mechanical tools are frequently used. Cassava pulverisers are essential machines for shearing cassava cakes into fine particles. Determining a method to predict the time to next failure occurrence of a cassava pulveriser is desirable for reducing maintenance costs, ensuring equipment availability, and reducing the Mean Time Between Failure (MTBF). This study presents a model that uses a pulveriser’s vibrational, sound, temperature, and feed capacity data to determine its time to next failure occurrence and maintenance actions.  Primary data of the pulveriser’s conditions was obtained over eight months, characterised, and assessed using Pearson’s R-Correlation Coefficient and Principal Component Analysis (PCA). Two multivariate prediction models were developed. While the Multiple Linear Regression (MLR) was the base predictive maintenance model, the Support Vector Regressor (SVR) was the improved model that considered the non-linearity of the independent variables with the dependent variable. The performance of the MLR and SVR models were evaluated using the Root Mean Square Error (RMSE), Multiple R-squared score, Mean Absolute Deviation (MAD), and Adjusted R-squared score metrics. Subsequently, the SVR model was deployed to a web-based application. The results of this study revealed MTBF of approximately 12 days and a correlation of all independent variables with the cassava pulveriser’s time to next failure occurrence. For the MLR model, a Multiple R-squared score of 0.2823, RMSE of 4.023, MAD of 3.0462, and Adjusted R-squared value of 0.14939 were obtained. The MLR model underfit the data set, and predictions were approximately three days away from the actual failure days on average. In comparison, the SVR model produced a Multiple R-squared score of 0.7524, Adjusted R-squared value of 0.7065, MAD of 1.1538, and RMSE of 2.3632 when implemented with its parameters, C value of 24, Gamma value of 0.042, Epsilon of 0.03, and a Radial Basis Function (RBF) Kernel. These results validated the SVR model as a reliable regression model for the pulveriser data set. The Multiple R-squared score indicates that 75% of the independent variables selected sufficiently explained the values of the dependent variable and the MAD outlines that the predictions are one day away from the actual failure time on average. In conclusion, the developed SVR model successfully modelled the deterioration trends of the cassava pulveriser and provided reliable predictions of its time to next failure occurrence to aid maintenance planning. This study recommends continuous data collection and retraining of the SVR model to gain ongoing insights into the dynamics of the cassava pulveriser.
Análisis Estadístico de Sobretensiones por Maniobra de energización en Líneas de Transmisión de Extra Alta Tensión
Authors: Cuenca Wilian , Calle John
Published: January 2023

En este trabajo se aplican las distribuciones Gaussiana y Weibull modificada para obtener las sobretensiones representativas de maniobras de energización en líneas de Extra Alto Voltaje y se comparan los resultados obtenidos en las sobretensiones representativas fase-tierra y fase-fase para tres escenarios de energización. Además, se expone la metodología para realizar un estudio estadístico de sobretensiones en el software ATPDraw, tomando como caso de estudio la interconexión Ecuador-Perú 500 kV. Los resultados demuestran que ambas distribuciones son aplicables para un análisis estadístico de sobretensiones si se consideran magnitudes de voltaje con igual probabilidad de aparecer en el sistema.
Sosialisasi Dampak Sampah Laut sebagai Upaya Peningkatan Kepedulian Masyarakat Terhadap Lingkungan di Desa Pesisir Besuki, Kabupaten Situbondo
Authors: Sakinah Wazirotus , Saifurridzal  , Septiningtyas Dina Tri , Arianto Pratama Yuli
Published: January 2023

Plastic waste is generally discarded in waters from the river that will eventually empty into the sea and directly discharged into the high seas as happened in the village of Pesisir Besuki, Situbondo district. The problems faced by partners are the lack of public awareness of the short-term and long-term impact of waste disposal activities in the waters and poor management of waste management. So that required waste socialization that include the guidance in environmentally friendly waste management and able to increase awareness of coastal communities to care for the environment. This community dedication use socialization as method with questionnaire before and after activity. The results obtained after the activities carried out are increasing the insight of the people of the Pesisir Village, Besuki District and increasing awareness of the environment so that they are trying to manage the waste they produce independently. According to the questionnaires result, before socialization waste management in Besuki Coastal Region has percentage 73% citizen throw their wastes in the sea or/and the river, 27% has been burned, and 0% in temporary garbage disposal. After socialization, it became 13% throw their waste in the sea or/and the rever, 7% in temporary garbage disposal, and 80% choose to burn their wastes. Generally, they does not have the basic knowledge about marine debris impact with percentage up to 80% and the citizen who know about the knowledge is 20%. Their interest about self waste management is 33%. But after socialization, it became 67% for their interest.

Keywords : Waste socialization, Waste Management,  Environmental Care
Edukasi dan Sosialisasi Kesehatan Lansia Pasca Pandemi COVID di Kemuning Lor Jember
Authors: Harlianingtyas Irma , Kusumawardani Devi Arine , Taufika Ramadhan , Hartatie Dian , Supriyadi
Published: January 2023

COVID-19 causes an increase in morbidity and mortality until 2021. One of the important components in dealing with the threat of the Covid-19 pandemic is care for the elderly group. Jember Regency as one of the districts that experienced an increase in the percentage of the elderly from 2018 to 2020 requires special attention regarding the prevention of COVID-19 transmission in the elderly. Based on the survey results to service partners, several problems that need to be resolved are the lack of knowledge about increasing immunity, especially among the elderly, partners still do not have awareness about the dangers of the COVID-19 virus, partners have not implemented health protocols such as social distancing, washing hands regularly, wearing masks when leaving the house, and spraying disinfectants regularly. The solution provided by the proposing team is the service team providing education about the importance of healthy living and to increase awareness while adhering to health protocols during the pandemic.  This activity was attended enthusiastically by the participants. this can be measured by 100% of the invitees attending the event. The education and socialization running smoothly. Communities are equipped with the knowledge and skills to make hand sanitizer independently. After this activity, the community is motivated to maintain health and comply with health protocols.
THAILAND STUDENTS’ DIFFICULTIES AND MOTIVATION IN STUDYING BIPA AT UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA
Authors: Srikandi Cut Novita
Published: January 2023

This study was conducted to identify the difficulties, challenges, and motivations of foreign students studying Bahasa at the Universitas Muhammadiyah Sumatera Utara (UMSU). This research was conducted by taking data from 12 foreign students from Thailand who took part in the Bahasa Indonesia Bagi Penutur Asing (BIPA) program at UMSU as research respondents. Observations, questionnaires, and interviews were used as research materials to obtain data and analyzed using the descriptive qualitative method by looking at the percentage only. The results showed that there were several difficulties faced by BIPA students, including; difficulty pronouncing some phonemes in Bahasa; lack of time both in learning and practicing Bahasa; lack of confidence to speak Bahasa; challenging teaching materials, students’ cultural background; the different languages of the learners; and the lack of additional resources that can be accessed online. It was also found that the respondents had a positive attitude and high motivation when learning Bahasa. Further findings indicate that BIPA teachers’ role also motivates students to learn Bahasa. Overall, foreign students have a positive attitude and high motivation to learn Bahasa if they get encouragement and guidance from the teacher and the surrounding environment.
UPAYA MENINGKATKAN KEMAMPUAN LITERASI DIGITAL MAHASISWA DENGAN PELATIHAN RENDERFOREST.COM
Authors: Batubara Muhammad Hasyimsyah , Nasution Awal Kurnia Putra , Lbs Mukhlis , Nurmalina Nurmalina
Published: January 2023

Kemampuan menggunakan teknologi menjadi semakin penting bagi mahasiswa di era sekarang. Banyak pekerjaan membutuhkan keterampilan digital dasar, seperti kemampuan menggunakan email, membuat dan mengedit dokumen, design dan melakukan pencarian di internet. Penguasaan literasi digital menjelma sebagai pendukung sarana pembelajaran dalam memudahkan pendidik dan peserta didik untuk memahami topik yang sedang dibahas. Namun menurut penelitian menunjukkan bahwa banyak anak muda tidak memiliki keterampilan literasi digital yang mereka butuhkan untuk berpartisipasi penuh di dunia digital. Dalam upaya meningkatkan kemampuan literasi digital mahasiswa dapat dilakukan dengan memberikan pelatihan cara penggunaan berbagai digital tools, salah satu cara dengan memperkenalkan website Renderforest.com. Pada PkM ini akan dikupas fitur-fitur yang tersedia di Renderforest.com seperti untuk membuat berbagai macam video animasi seperti video presentasi, video iklan, video promosi, video tutorial, dan lain sebagainya. Dengan semakin pentingnya literasi digital di dunia saat ini, sangat penting bagi mahasiswa untuk memiliki keterampilan digital yang dibutuhkan untuk menjadi sukses.
Overview of the Characteristics of Meningocele Patients at Dr. Kariadi General Hospital, Semarang, Indonesia
Authors: Irawan Putro Aji Nawa , Erie B. P. Setya Budi Andar
Published: January 2023

Background: Meningocele is a medical condition where there is a defect in the spinal area, which allows protrusion of cerebrospinal fluid through the defect. Although epidemiologically, this case is relatively small, given the potential for high morbidity and mortality caused by this disorder, it becomes urgent for further exploration regarding meningocele. This study aimed to provide a clinical picture of meningocele patients at Dr. Kariadi General Hospital, Semarang, Indonesia.

Methods: This study was a descriptive observational study. A total of 12 meningocele patients participated in this study. Observation of clinical data and management of meningocele patients was carried out in this study. Univariate analysis was carried out with the help of SPSS software.

Results: The mean age of the patients when they were first treated was 533 days, and the average age when they were first operated on was 191.5 days. Meningocele patients have an average hospital stay of 16.5 days. The majority of patients are male. The majority of meningocele patients have congenital limb anomalies. The majority of patients have a neural tube defect located in the lumbosacral region. The majority of meningocele patients have no infectious complications, and the majority receive VP-shunt placement.

Conclusion: Meningocele patients at Dr. Kariadi General Hospital, Semarang, Indonesia, mostly have an overview of the location of neural tube defects in the lumbosacral region and have complications of limb anomaly.