bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisa Proyek Pengembangan Sistem Informasi Perpustakaan Umum Menggunakan Unified Modeling Language
Authors: Nurseptaji Adi , Adamsyah Agusdael , Wildan Mochamad , Akmal Muhamad , Ardiansyah Pyan , Firmansyah Ricky
Published: November 2021

The library is an important facility as a source of information, especially in the world of education to support learning activities for students and knowledge seekers to add insight and knowledge. To facilitate and accelerate library services, a Library Information System is needed in order to increase productivity, effectiveness and efficiency in the library. For the development stage of the library information system using the Unified Modeling Language (UML) as a tool for modeling and documenting the Library Information System. With the Public Library Information System Development Project Analysis Using the Unified Modeling Language, it is hoped that it can improve service, productivity, effectiveness and efficiency in libraries to increase reading interest for students and facilitate and speed up the transaction process of borrowing and returning books to the library.
Prinsip Non-Diskriminasi dalam Penerapannya pada Peraturan Bank Indonesia tentang Gerbang Pembayaran Nasional
Authors: Ananda Puja Dwi , Ramlan Ramlan
Published: November 2021

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaturan prinsip non diskriminasi berdasarkan GATs dan Impelementasinya di Indonesia dilihat dari pengaturan mengenai National Payment Gateway. Metode yang digunakan adalah metode penelitian hukum normatif dengan pendekatan sejarah (historical approach), perundang-undangan (normative approach) dan kasus (case approach). Hasil penelitian menunjukkan bahwa pengaturan mengenai prinsip non diskriminasi jelas diatur di dalam GATs, yaitu Pasal II mengenai prinsip Most Favoured Nation dan Pasal XVII mengenai prinsip national treatment. Adapun prinisp non diskriminasi menyebutkan bahwa suatu negara tidak boleh melakukan perlakuan yang berbeda terhadap negara lain yang menjadi anggota dari GATs-WTO sebagaimana yang telah dinyatakan dalam Schedules of Spesific Commitment. Indonesia menerbitkan peraturan mengenai National Payment Gateway dimana beberapa pasal dalam peraturan tersebut berbeda dengan komitmen yang didaftarkan dan membatasi akses pasar dari jasa negara lain.
Stateless Person dalam tinjauan Hukum Nasional dan Hukum Internasional di Indonesia
Authors: Khalid Fadjri , Ardianto Budi
Published: November 2021

Penelitian ini bertujuan untuk mengetahui bagaimana pengaturan Orang Tanpa Kewarganegaraan atau Stateless Person berdasarkan instrumen hukum internasional maupun instrumen hukum nasional di Indonesia. Indonesia yang terdampak dalam globalisasi karena gencarnya promosi pariwisata memiliki pengaturan terhadap lalu lintas orang asing melalui Undang-undang Nomor 6 Tahun 2011 tentang Keimigrasiaan dan disisi lain Indonesia tidak mengakui keberadaan Orang Tanpa Kewarganegaraan berbeda dengan pengaturan sebagaiman tercantum dalam Convention Relating To The Status of Stateless Persons 1954. Penelitian ini bertujuan untuk mengetahui bahwa pengaturan mengenai Orang Tanpa Kewarganegaraan di Indonesia untuk saat ini belum diatur secara khusus. Walaupun Indonesia telah meratifikasi International Covenant on Civil and Political Rights. Hal ini menunjukkan bahwa Indonesia belum mengatur dengan tegas dan dalam penanganannya terhadap Orang Tanpa Kewarganegaraan cenderung lambat yang mengakibatkan pendetensian melebihi ambang dari batas yang ditentukan. Adapun rumusan masalah yang diangkat yakni bagaimana  pengaturan Orang Tanpa Kewarganegaraan dalam Hukum Internasional dan dalam hukum keimigrasian Indonesia beserta konsukuensi hukum yang di dapat. Metode penelitian yang digunakan adalaha tipe normative dengan cara studi pustaka. Hasil penelitian ini menunjukkan bahwa pengaturan Orang Tanpa Kewarganegaraan di lingkup Internasional berbeda dengan pengaturan di Indonesia karena tidak adanya peraturan yang tegas mengenai hal ini.
Polluter Pays Principle Terkait Pertanggungjawaban Corporate PTTEP Australasia Terhadap Pencemaran Minyak Di Laut Timur Indonesia
Authors: Panjaitan Annisah Dian Utami , Novianti Novianti , Farisi Mochammad
Published: November 2021

This research is aimed to analyze and determine the 16th provision principle of the declaration on environment and development, namely the polluter pays principle, as one of the state’s form of accountability towards the polluting across borders between PTTEP Australia and Indonesia. This is a juridical research, which analyzes the issue discussed through the use of many realted sources. The Polluter Pyas Principle, as a form of State responsibility in environmental pollution, has some advantages and disadvantages when applied as a recommendation by the OECD (Organization for Economic Cooperation and Development). From a legal perspective, this principle can be applied as a civil liability law, whereas from an economic perspective, it can be viewed as effort to control pollution by means which the polluter has an obligation to pay for the environmental pollution that he/she caused. Even so this principle also has its weakness, in an economic approach this principle is difficult to determine the determination of the cost of loss. In some countries themselves have applied this principle in handling cases of environmental pollution. In the case of cross-border environmental pollution, the principle of good neighborliness and the principle of state responsibility in dealing with pollution cases as a sign of State’s goodwill to comply with existing international law. The case of environmental pollution itself is not only the State that can sue, but a group of people or the community can also sue, if they feel harmed by the pollution that occurs. One of them is by carrying out Class Action in holding accountable for the consequences of pollution that has occurred, and is detrimental to a group or large number of people. Even though international environmental law is a soft law, it can become hard law depending on the pollution case that occurs. Even so, International Environmental Law contained in the Stockholm Declaration, Rio de Jeneiro, Civil Liability Convention and other related international arrangements have been very good in their regulatory fields. Only the state which ratifies the convention applies according to the pollution case that occurs.
A Scoping Review of Trauma-Informed Curricula for Primary Care Providers
Authors: Gundacker Constance , Barreto Tyler W. , Phillips Julie P.
Published: November 2021

Background and Objectives: Traumatic experiences such as abuse, neglect, and household dysfunction have a lifetime prevalence of 62%-75% and can negatively impact health outcomes. However, many primary care providers (PCPs) are inadequately prepared to treat patients with trauma due to a lack of training. Our objective was to identify trauma-informed approach curricula for PCPs, review their effectiveness, and identify gaps.
Methods: We systematically identified articles from Medline, Scopus, Web of Science, Academic Search Premier, Cochrane, PsycINFO, MedEd Portal, and the STFM Resource Library. Search term headings “trauma-informed care (TIC),” “resilience,” “patient-centered care,” “primary care,” and “education.” Inclusion criteria were PCP, pediatric and adult patients, and training evaluation. Exclusion criteria were outside the United States, non-English articles, non-PCPs, and inpatient settings. We used the TIC pyramid to extract topics. We analyzed evaluation methods using the Kirkpatrick Model.
Results: Researchers reviewed 6,825 articles and identified 17 different curricula. Understanding health effects of trauma was the most common topic (94%). Evaluation data revealed overall positive reactions and improved knowledge, attitudes, and confidence. Half (53%) reported Kirkpatrick level 3 behavior change evaluation outcomes with increased trauma screening and communication, but no change in referrals. Only 12% (2/17) evaluated Kirkpatrick level 4 patient satisfaction (significant results) and health outcomes (not significant).
Conclusions: Pilot findings from studies in our review show trauma-informed curricula for PCPs reveal positive reactions, an increase in knowledge, screening, communication, and patient satisfaction, but no change in referrals or health outcomes. Further research is needed to examine the impact of trainings on quality of care and health outcomes.
AS MULHERES E O DIREITO A CIDADE: INVESTIGANDO ESSA PERCEPÇÃO
Authors: Fernandes Daniela De Borba , De Oliveira Giovana Mendes
Published: November 2021

O presente trabalho é um artigo surgido a partir de um trabalho de conclusão de curso (TCC) do curso de Geografia - Bacharelado, da Universidade Federal de Pelotas (UFPel). A pesquisa tem como principal objetivo saber como as mulheres compreendem o seu direito à cidade, e além disso, se o gênero é também um fator determinante para que alguém tenha ou não este direito. A pesquisa perpassa por discussões acerca de cidade, direito à cidade e desigualdade de gênero. É uma pesquisa feminista e que critica e questiona todas as desigualdades presentes nos espaços urbanos e perpassa por conceitos de geografia de gênero e geografia urbana.
Teaching Business Transaction Cycles Using a Hands-On Activities Approach
Authors: Wang Tawei , Chiu Victoria , Wang Yunsen , Chiu Tiffany
Published: November 2021

We present a novel hands-on approach for teaching students the concepts and business processes of transaction cycles. Specifically, the hands-on activities focus on sales and procurement cycles. Upon completion of the hands-on activities, students will (a) develop a better understanding of the business processes and business forms for sales and procurement cycles and (b) build relevant critical thinking skills. We evaluate students' learning by providing a comparison between students who learned the concepts of transaction cycles and business processes and performed the transaction cycle hands-on activity in class versus those students who only learned the concepts of transaction cycles and business processes in class. Although the hands-on activities were used in an accounting information systems class, they can also be applied to other business disciplines, such as engineering and project management classes.
Financial Reporting, Auditing, Analyst Scrutiny, and Investment Efficiency
Authors: Chan Derek K. W. , Liu Nanqin
Published: November 2021

This paper presents an economic framework to study strategic interactions along the analyst-auditor-owner disciplinary chain, in which the auditor examines the financial reports prepared by the owner, and the analyst uncovers financial misreporting, as well as audit failure. We find that although analyst scrutiny ex post detects misreporting, it ex ante aggravates the owner's misreporting behavior and further impairs financial statement reliability if the legal penalties for the auditor and the owner are small. We also show how the effects of a regulation depend on its target's disciplinarian(s). Specifically, (1) although enhancing the auditor's legal liability always increases audit quality and financial statement reliability, it decreases investment efficiency if and only if the analyst is highly independent, and (2) increasing the owner's misreporting penalty decreases investment efficiency if and only if either of (but not both) the regulations on the auditor and the analyst are strict.

JEL Classifications: M41; M42; M48.
Emotional Correlates of the COVID-19 Pandemic in Individuals With and Without Diabetes
Authors: Myers Barbara A. , Klingensmith Rachel , de Groot Mary
Published: November 2021

OBJECTIVE

To compare the mental health experiences associated with coronavirus disease 2019 (COVID-19) in adults with and without diabetes.

RESEARCH DESIGN AND METHODS

Between 29 May 2020 and 30 June 2020, 2,176 U.S. adults completed an online survey including demographics, COVID-19 experiences, depression (eight-item Patient Health Questionnaire) and anxiety (seven-item Generalized Anxiety Disorder) symptoms, perceived stress (10-item Perceived Stress Scale), resilience (Brief Resilience Scale), and diabetes-related distress (in participants with diabetes) (17-item Diabetes Distress Scale).

RESULTS

Mean age was 49.6 years (SD 16.9); participants were primarily women (80.0%) and White (88.3%), with an annual household income of ≥$60,000 (57.6%). One hundred reported a diagnosis of type 1 diabetes (4.6%), 304 type 2 diabetes (13.9%), and 145 prediabetes (6.6%). Nearly one-third (29.7%) indicated decreases in income attributable to the pandemic. Participants with type 1 diabetes had higher levels of diabetes distress than participants with type 2 diabetes (P < 0.05), with moderate severity in both groups. Participants with type 2 diabetes had significantly more comorbidities and COVID-19 risk factors than all other groups (all P < 0.01). After controlling for covariates, participants with type 2 diabetes reported significantly more depressive symptoms than those without diabetes (P < 0.05) and lower levels of resilience (P < 0.05). Subgroup analyses by sex and age indicated that women and younger adults, particularly those age 18–34 years, reported significantly more depression and anxiety symptoms, stress, and diabetes-related distress and lower levels of resilience than men and adults age ≥51 years.

CONCLUSIONS

In this naturalistic observational study, participants with type 2 diabetes reported more depression, lower resilience, and significantly more COVID-19 risk factors and medical comorbidities than participants without diabetes. Overall, our participants demonstrated worse depression and anxiety symptoms during compared with before the pandemic.
PENYULUHAN TENTANG KUALITAS TIDUR PADA MASA PANDEMI COVID-19
Authors: Sulistyani Sulistyani
Published: November 2021

ABSTRAK
Pandemi COVID-19 menimbulkan berbagai masalah kesehatan masyarakat di seluruh dunia, salah satunya adalah trauma psikis yang dapat mempengaruhi kualitas tidur. Kualitas tidur sulit untuk didefinisikan namun dapat diidentifikasi dengan istrumen penilaian PSQI Pittsburgh Sleep Quality Index). Kualitas tidur yang baik mempunyai peran penting dalam meningkatkan fungsi kognitif terutama retensi memori. Kualitas tidur malam yang buruk menyebabkan kantuk di siang hari dapat mempengaruhi kesehatan fisik dan kognitif pada pelajar atau mahasiswa siswa dan mempengaruhi nilai akademik. Tujuan penyuluhan ini adalah untuk meingkatkan pengetahuan tentang kualitas tidur yang baik. Hasil penyuluhan terdapat 60% gangguan tidur pada peserta penyuluhan dan terdapat peningkatan pengetahuan tentang kualitas tidur. Simpulan yang dapat diambil adalah penyuluhan dapat meningkatkan pengetahuan tentang kualitas tidur yang baik.
 
ABSTRACT
The COVID-19 pandemic causes psychological trauma. It has an impact on sleep quality. PSQI (Pittsburgh Sleep Quality Index assessment instrument) is the instrument to identify sleep quality disorders. Good quality sleep can improve cognitive function, particularly memory retention. A poor night's sleep quality causes daytime sleepiness and affects physical, cognitive health, and academic grades. The purpose of the counseling is to increase knowledge about good sleep quality. There were 60% sleep disorders in counseling participants and an increase in knowledge about sleep quality. The conclusion is counseling can increase knowledge about good sleep quality.
Sosiaalisen median kommenttien analyysi multimodaalisesta näkökulmasta digitaalisen journalismin ja poliittisen viestinnän tutkimuksessa
Authors: Salonen Margareta , Kannasto Elisa , Paatelainen Laura
Published: November 2021

Societal discussions flow on social media platforms that are studied by researchers in multiple ways and through various kinds of data sets that are extracted from them. In the studies of these discussions, multimodality unravels the semiotic modes that are communication resources through which meanings are socially and culturally created and expressed. In addition, the viewpoint of affordances can be used for viewing the functions of social media platforms and their discussions. Furthermore, this review was conducted to better understand how social media comments are researched from the perspective of multimodality in the context of digital journalism and political communication. A systematic literature review and qualitative content analysis were used as methods. The review discovered that the studies under review were not that high in multimodality and that text as an individual mode was the most common one. Furthermore, Twitter was the most researched platform and the one where the use of modes was more thoroughly explained.
Pengaruh Bauran Promosi, Harga, Display Produk dan Kualitas Layanan terhadap Keputusan Pembelian pada Apotek Anugerah Farma di Kota Gorontalo
Authors: Suyanto Mohamad Afan , M Muh Akmar , Karundeng Deby Rita
Published: November 2021

The research aims to determine the effect of: Promotion Mix on Purchasing Decisions, Prices on Purchasing Decisions, Product Display on Purchasing Decisions, Service Quality on Purchasing Decisions at Anugerah Farma Pharmacy in Gorontalo City and to determine the Effect of Promotion Mix, Price, Product Display and Service Quality on Purchasing Decision at Anugerah Farma Pharmacy in Gorontalo City

This research approach is a qualitative descriptive approach. This type of research is a survey, namely analyzing the facts that support the information needed to support the research discussion, in solving and answering the main problems posed. The data were obtained through distributing questionnaires, then the data were analyzed descriptively and multiple regression analysis.

The results showed that partially the promotion mix had a positive and significant effect on purchasing decisions. Price has a positive and insignificant effect on the decision. Product display has a positive and significant effect on purchasing decisions. Service quality has a positive and significant effect on purchasing decisions at Anugerah Farma Pharmacy and simultaneously the promotion mix, price, product display and service quality have a positive and significant effect on purchasing decisions at Anugerah Farma Pharmacy, Gorontalo City.
Dampak Pandemi Covid-19 terhadap Bisnis Online Shop (Baju Anak-Anak) di Kota Serang
Authors: Hidayat Syarif
Published: November 2021

This study aims to find out and analyze the impact of the COVID-19 pandemic on online shop businesses in the city of Serang. The research method used is descriptive qualitative method, using sources from informants. The process of selecting key informants rolled like a snowball. The research time is March to June 2021. Data collection techniques use field observations, interviews with research objects, and documentation as research supporting materials. The research locus is in Serang City. The results of the study found that the impact of the Covid-19 pandemic on the online shop business was a decline in sales because consumers were now more focused on buying basic necessities and medicines for health.
Formulasi dan Uji Efektivitas Sediaan Body scrub Labu Kuning (Curcubita moschata)
Authors: Leny Leny , Ginting Indra , N Sitohang Tiary , Fatimah Hanum Siti , Hafiz Ihsanul , Iskandar Benni
Published: November 2021

Penggunaan body scrub merupakan salah satu perawatan kulit untuk mengangkat sel- sel kulit mati akibat radikal bebas, labu kuning merupakan salah satu tanaman yang banyak mengandung beta karoten serta vitamin C dan E yang berfungsi sebagai antioksidan alami untuk menangkal radikal bebas pada kulit. Penelitian ini bertujuan untuk membuat formulasi sediaan krim body scrub yang mengandung sari labu kuning (Cucurbita moschata). Sari labu kuning diformulasikan dalam variasi konsentrasi 10%, 15% dan 20%. Evaluasi formula krim body scrub yang dilakukan meliputi uji homogenitas, organoleptis, pH, stabilitas menggunakan metode cycling test, uji iritasi pada kulit, dan efektivitas pada kulit dengan mengamati kemampuan menghaluskan kulit dan meningkatkan kadar air pada kulit dengan menggunakan perangkat skin analyzer. Hasil penelitian menunjukkan bahwa sediaan krim body scrub sari labu kuning (Cucurbita moschata) homogen saat difomulasikan, memiliki bentuk, warna, tidak berubah setelah pengujian stabilitas dengan metode cycling test, dan mempunyai nilai pH yang memenuhi persyaratan pH kulit, serta tidak menimbulkan iritasi pada kulit sukarelawan. Sediaan yang dengan konsentrasi sari labu kuning 20% (F3) memiliki efektivitas paling mendekati kontrol positif yaitu mampu memperbaiki kehalusan kulit (evenness) hingga 50,00% dan meningkatkan kadar air (moisture) hingga 46,33%. Kesimpulan dari penelitian ini adalah sari labu kuning (Cucurbita moschata) dapat diformulasikan dalam bentuk sediaan krim body scrub yang stabil dan mampu memperbaiki kondisi kulit yang kasar menjadi lebih baik.
O que quer dizer viver uma Ecologia Integral? Reflexões de Papa Francisco e Monsenhor Bruno-Marie Duffé
Authors: Abreu Helen Teixeira Sousa
Published: November 2021

O presente artigo trata do tema da Ecologia Integral e sua relação com o desenvolvimento humano e a espiritualidade cristã, como descritos por Monsenhor Bruno-Marie Duffé na palestra de referência e nos documentos do Papa Francisco, principalmente a encíclica Laudato si’. A Ecologia Integral só pode ser vivida se considerados seus aspectos social, cultural, ambiental e espiritual, pois a realidade é integrada e não fragmentada. Para isso, é preciso questionar e abandonar o paradigma tecnocrático, a partir do qual as possibilidades técnicas e a ideia de progresso econômico definem o que deve ser feito, e abraçar um novo paradigma cultural, que resgate a memória e construa a esperançadas comunidades e que conduza as pessoas a viverem em harmonia com a natureza, da qual a humanidade também faz parte. Esse paradigma é baseado no cuidado mútuo, no estabelecimento de limites para a técnica e consumo, na contemplação da natureza e na solidariedade entre as pessoas.
The Role of Nano-Silicon and Other Soil Conditioners in Improving Physiology and Yield of Drought Stressed Barley Crop
Authors: Mahmoud Abdel Wahab M. , Hassan A.Z.A , Mottaleb Shady Abdel , Rowezak Mohamed M. , Salama Azza M.
Published: November 2021

A field experiment was conducted in sandy soil to assess the effect of different sources of soil conditioners on barley (Hordeum vulgare L. cv. Giza 137) growth and its yield under drought stress. Plants were exposed to two levels of drought stress until grain maturity: (A) drought at 75% available water (AW) with NPK as control (treatment, T1); (B) mild drought stress at 50% AW with foliar spray of nano-silicon at 75 ppm (treatment, T2), foliar spray of nano-zeolite at 75 ppm (treatment, T3), perlite at 4 tons/h (treatment, T4), natural zeolite at 600 kg/ha (treatment, T5), bentonite at 4 tons/h (treatment, T6), and a combined treatment of T2+T3+T4+T5+T6 at the half amount of each material (T7). All the treatments received the recommended doses of organic matter. Vegetative growth and yield characters as well as anatomical characters were recorded. The physical and chemical soil properties were significantly improved by both foliar and soil conditioners application. The nutrients content of the barley crop were augmented under combined treatment (T7) as compared to other treatments. Under that treatment, barley crop chemical components, i.e. protein, ash, chlorophylls, amino acids, vitamins, and fibre were significantly higher compared to other treatments. In addition, gibberellic acid (GA3) and abscisic acid (ABA) content besides antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD) activities were significantly affected by all treatments. The economical profits were achieved, as reflected by an investment factor value equal to or higher than 3, and this was achieved for all tested nanosilicon, zeolite, and soil conditioners indicated the effectiveness and profitability of studied treatments.
Type I interferon therapies of multiple sclerosis and hepatitis C virus infection
Authors: Jasyk Izabella , Siednienko Jakub
Published: November 2021

Interferons type I (IFN-I), activated following a bacterial or viral infection, play a major role in the induction and regulation of the immune system. The immune response results in viral RNA and binds to receptors such as RIG-I-like receptors (RLRs) or Toll-like receptors, leading to the IFN-I signaling cascade. Thanks to its cellular function, IFN-I is widely used in therapies for such diseases as multiple sclerosis (MS) and hepatitis C disease (HCD).

MS is a neurological, autoimmune, chronic inflammatory disease of the central nervous system (CNS). During MS, nerve cell demyelination is observed due to the myelin heaths and oligodendrocyte damage. As a result, neuronal signal and neuron communication are attenuated. The mechanism of MS is still unknown. MS therapy applies interferon-β (IFN-β). IFN-β therapy has been used since the last century, but the therapeutic mechanism of IFN-β has not been completely understood. MS can lead to four syndromes: clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS).

HCD occurs as a result of infection with the hepatitis C virus (HCV), belonging to the Flaviviridae family. HCV is a blood-borne virus with a positive single-stranded RNA. A vaccine for HCV is not available yet. HCD can lead to liver damage or cancer. In HCD interferon-α therapy (IFN-α) is applied. As with MS, the mechanism of IFN-α therapy is not completely known.
Kobalamina – właściwości biomedyczne i niedobór w ujęciu biochemicznym
Authors: Rzepka Zuzanna , Słaby Daniel , Wrześniok Dorota
Published: November 2021

Abstrakt

Kobalamina (witamina B12) jest rozpuszczalnym w wodzie związkiem organicznym, zaliczanym do witamin grupy B. Złożona budowa i polarność cząsteczki witaminy B12 sprawiają, że do jej prawidłowego wykorzystania i przemian w organizmie człowieka niezbędny jest udział wyspecjalizowanych białek. Głównym źródłem kobalaminy człowieka jest pokarm pochodzenia zwierzęcego. Ze względu na rezerwy tkankowe tej witaminy, jej niedobór ujawnia się dopiero po kilku latach niewystarczającej podaży z pożywieniem. Badania przesiewowe pod kątem deficytu kobalaminy są jednak uzasadnione u osób z czynnikami ryzyka hipokobalaminemii, takimi jak: stan po resekcji żołądka lub jelita cienkiego, dieta wegańska, długotrwałe stosowanie metforminy, antagonistów receptora histaminowego H2 oraz leków z grupy inhibitorów pompy protonowej, a także podeszły wiek.

Witamina B12 jako kofaktor enzymatyczny uczestniczy w licznych przemianach wewnątrzmitochondrialnych oraz w syntezie metioniny, niezbędnej do powstania S-adenozylometioniny istotnej w procesie metylacji cząsteczek biologicznie czynnych. Przez powiązania metaboliczne z kwasem foliowym kobalamina wpływa na proces syntezy DNA i podział komórki. Obecnie coraz częściej zwraca się uwagę na potencjalny udział niedoboru witaminy B12 w patogenezie chorób neurodegeneracyjnych, a także nowotworowych. Niedobór kobalaminy na poziomie molekularnym destabilizuje genom komórek, zwiększając ryzyko ich złośliwej transformacji. Jednak u osób z chorobą nowotworową lub obciążonych ryzykiem jej rozwoju witamina B12 może nasilać ekspansję komórek neoplastycznych.
PENGEMBANGAN MODUL IPA MATERI HUBUNGAN MAKHLUK HIDUP DAN LINGKUNGANNYA BERBASIS PENDEKATAN KONTEKSTUAL
Authors: Gita Sari Damara , Annisa Muhsinah , Nanna Wilda Indra
Published: November 2021

This study aimed to produce teaching materials in the form of IPA Modules of living creatures and the environment based on a quality contextual approach in terms of expert validation and testing to students. This development research uses the ADDIE model development procedure (analysis, design, development, implementation, evaluation). The subjects of this study are students of grade IV-B SD Negeri 033 Tarakan with a total of 24 people. Criteria for quality of IPA module material of living creature relationship and environment, viewed material validation result 98% (very valid), design validation 87.5% (very valid), validation of language 97% (very valid), 100% validation validation (very valid) and validation practitioner 88% (very valid), so the average validation result gets a percentage of 94% (very valid). Based on the questionnaire, the students' responses were 93% (very good) Based on what has been explained that the IPA module based on the contextual approach that has been developed is qualified.
Variables asociadas a la carga en cuidadores primarios de personas con enfermedad renal crónica
Authors: Arredondo Pantaleón Aranel de Jesús , Jurado Cárdenas Samuel
Published: November 2021

El objetivo del presente estudio fue identificar las variables del cuidado que se relacionan significativamente con la carga del cuidador, y cuantificar la intensidad del malestar que producen dichas variables en los cuidadores primarios de personas con enfermedad renal crónica. Participaron 31 cuidadores, quienes respondieron la Escala de Carga del Cuidador de Zarit y un cuestionario elaborado ex profeso que evaluó la intensidad del malestar que generan las variables del cuidado; cabe mencionar que entre dichos cuidadores, 71% mostró algún grado de carga. Se encontraron relaciones significativas entre la carga y ciertas variables de tipo social, económico y hospitalario referidas a la rigurosidad del tratamiento, la salud del paciente, el rol del cuidador y la dependencia del paciente, mismas que también fueron valoradas por los participantes como generadoras de niveles elevados de malestar. Dado los resultados, es necesario identificar a los cuidadores con carga, al igual que diseñar e implementar intervenciones orientadas a promover su bienestar biopsicosocial.
La autoeficacia y su influencia en la insatisfacción de la imagen corporal: revisión sistemática
Authors: Nápoles Neyra Nayalis , Blanco Vega Humberto , Jurado García Perla Jannet
Published: November 2021

Introducción: La autoeficacia influye de forma efectiva en la imagen corporal de los adolescentes. Objetivo: Analizar por medio de una revisión sistemática la relación entre autoeficacia y la insatisfacción de la imagen corporal. Método: Se realizó una búsqueda en las bases de datos Scopus, Scielo, Dialnet, Redalyc, Ebsco y Pubmed. Resultados: Inicialmente se identificaron 479 documentos, de los cuales 25 cumplieron con los criterios de inclusión. Discusión: Mediante la revisión efectuada, se confirma que la autoeficacia es una variable mediadora entre el estilo de vida saludable en cuanto a la alimentación y el ejercicio físico y las percepciones corporales y la satisfacción con la imagen corporal.
Efecto de la atención plena compasiva en dolor, ansiedad y respuestas fisiológicas en la artritis reumatoide
Authors: Patoni Maldonado Roberto Israel , Rodríguez Henríquez Pedro José , Salinas Rivera Edgar , Moreno Coutiño Ana Beatriz
Published: November 2021

La artritis reumatoide (AR) es una enfermedad autoinmune caracterizada principalmente por dolor, inflamación, deformidad y destrucción persistente de las articulaciones afectadas. La AR suele estar asociada con sintomatología ansiosa debido a la falta de predictibilidad de los ataques de dolor y a las complicaciones de la enfermedad. El objetivo de este proyecto fue evaluar el efecto de la atención plena compasiva (APC) en la disminución de la percepción del dolor, sintomatología ansiosa y reactividad fisiológica ante estresores de pacientes con diagnóstico de AR, ya que previamente no se había investigado el efecto de la APC sobre estas variables en México. Participaron seis pacientes del hospital “Dr. Manuel Gea González” de la Ciudad de México, los cuales asistieron a una intervención de nueve sesiones con duración de dos horas cada una, a razón de una por semana. La intervención estuvo compuesta por psicoeducación, práctica y ejercicios para el hogar. Se implementó un diseño pretest-postest con muestreo a conveniencia. Los resultados mostraron una reducción significativa de la percepción del dolor, pero no de la sintomatología ansiosa. En las reacciones fisiológicas solo se obtuvieron cambios clínicos objetivos en algunas respuestas. La intervención con APC disminuye la percepción de dolor en pacientes con AR. Se sugiere un mayor número de participantes en futuros estudios, así como seguimientos a tres, seis y doce meses.
Sievietes reproduktīvās mazspējas iemesli un genomiskās pieejas to risināšanai. Promocijas darba kopsavilkums
Authors:   ,   Rīgas Stradiņa universitāte, Voložonoka Ludmila
Published: November 2021

Sievietes reproduktīvās mazspējas iemesli un genomiskās pieejas to risināšanai Sievietes reproduktīvās mazspējas ģenētisko cēloņu identificēšana, izmantojot mūsdienīgas ģenētiskās tehnoloģijas, vienlaikus saglabājot pacientu drošību un virzoties uz personalizētas ārstēšanas lietošanu, ir reproduktīvās medicīnas izaicinājums 21. gadsimtā. Darba mērķis bija demonstrēt genomisko tehnoloģiju lietojumu dažādos sievietes reproduktīvās mazspējas etapos reālos klīniskajos vai pētījumu apstākļos. Tika lietotas vairākas genomiskās metodoloģijas – pirmsimplantācijas embriju testēšanai, lai atlasītu embrijus bez iedzimtas monogēnas patoloģijas un hromosomālajām aberācijām, salīdzinošā genoma hibridizācija uz mikročipiem un mikrosatelītu analīze augļa hromosomu analīzei pārtraukušās grūtniecības materiālā, nosakot mātes šūnu kontaminācijas klātbūtni paraugā, un, visbeidzot, nākamās paaudzes sekvencēšana dzemdes kakla nepietiekamības izraisītu priekšlaicīgu dzemdību ģenētiskās etioloģijas raksturošanai. Paveiktais praktiskais darbs tika publicēts trijos zinātniskajos rakstos, kas veido trīs darba sadaļas. Salīdzinošā genoma hibridizācija uz mikročipiem apvienojumā ar lokusa ģenētiskās testēšanas metodēm deva iespēju veikt pirmsimplantācijas analīzi, lai atlasītu embrijus bez testētās patoloģijas, savukārt kombinācijā ar mikrosatelītu analīzi ļāva noteikt hromosomālās patoloģijas izraisošas agrīnas grūtniecības pārtraukšanos, vienlaikus mazinot mātes šūnu kontaminācijas izraisītas kļūdainas diagnozes iespēju. Lietojot nākamās paaudzes sekvencēšanu, tika identificēti gēnu varianti, kas potenciāli veicina nesindromiskas dzemdes kakla nepietiekamības attīstību. Gēnu ceļu bagātināšanas analīze atklāja palielinātu gēnu variācijas slogu gēnos, kas nodrošina audu mehānisko un biomehānisko izturību. Literatūras analīze ļauj secināt, ka gēnu skaits ar zināmu ietekmi uz sievietes reproduktīvās mazspējas attīstību nepārtraukti aug un aizvien lielāks gēnu skaits veido labu kandidātu kopu, kas gaida replikācijas pētījumus. Diagnostisko gēnu paneļu klīniskajai izveidei un lietošanai un ģenētisko sasniegumu iekļaušanai sievietes reprodukcijas klīniskajā praksē nepieciešama standartizēta identificēto gēnu klīniskās validitātes novērtēšana un labās prakses vadlīniju izstrāde.
Cobertura vacinal das gestantes em Ponte Nova – MG e fatores associados
Authors: Andrade Luana Silva de , Garcia Ruth Maria Alves
Published: November 2021

Objetivo: Estimar a Cobertura VacinalCV) dos gestantes no município de Ponte Nova – MG. Métodos: Trata-se de um estudo descritivo, quantitativo e retrospectivo realizado através da coleta de dados fornecidos pelo Departamento de Informática do Sistema Único de Saúde (DATASUS) - TABNET entre os anos de 2018 e 2020. Resultados: A CV das gestantes no município mineiro seguiu um padrão de queda em praticamente todos os anos analisados, sendo que a vacina da Influenza uma diminuição de 34,49% entre os anos de 2020, o mesmo ocorreu com a dT e com a dTpa gestante que teve uma queda de aproximadamente 44% quando comparados os anos de 2018 e 2020, já a dTpa gestante preconizada a todas as gestantes apresentou queda de 24,15% entre os anos de 2018 e 2020. Por fim, a CV da hepatite B para toda a população-alvo apresentou redução de 26,82% de 2018 para 2019 e elevação entre 2019 e 2020 de 30,51%. Conclusão: Constatou-se que a situação vacinal gestantes no município de Ponte Nova - MG e também no território brasileiro está abaixo dos valores de cobertura preconizado pelas entidades de saúde.
Light and Laser-based Treatments for Hidradenitis Suppurativa: A Systematic Review
Authors: Mukovozov Ilya , Mirali Sara , Khaslavsky Sofi , Kalia Sunil
Published: November 2021

Background: Hidradenitis suppurativa (HS) is characterized by painful, recurrent lesions occurring mainly in intertriginous areas. The pain, odor, and disfigurement caused by HS significantly impacts quality of life and is challenging to treat. A comprehensive systematic review evaluating the use of light and laser-based treatments for HS is lacking.
Methods: We performed a systematic review by searching Cochrane, MEDLINE and Embase. Title, abstract and full text screening, and data abstraction were done in duplicate.
Results: Forty studies met the inclusion criteria, representing a total of 821 patients. Included studies were comprised of 5 randomized within-patient controlled trials, 1 randomized controlled trial, and 34 case series. Overall, treatments with the most reported cases were laser surgery, photodynamic therapy (PDT), and laser field treatments which showed a response in 80% (n=344/431), 73% (n=122/167) and 71% (n=84/101) of treated patients respectively. The pooled response rate for psoralen plus ultraviolet A was 69% (n=9/13).
Conclusion: Our results suggest that laser surgery using carbon dioxide (CO2) laser or a combination of CO2 and Nd:YAG lasers has a moderate response rate for HS with the most reported cases. Laser for field treatment and PDT also had moderate response rates with a large number of reported cases. However, extrapolation of these results may be limited due to the majority of the studies being case series, lack of standardized outcomes being assessed, and insufficient long term follow up results.
Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 (TYK2) Inhibitor, Compared With Placebo and Apremilast in Moderate to Severe Psoriasis: Integrated Laboratory Parameter Results From the Phase 3 POETYK PSO-1 and POETYK PSO-2 Trials
Authors: Thaci Diamant , Gordon Kenneth , Gooderham Melinda , Strober Bruce , Korman Neil , Banerjee Subhashis , Banerjee Subhashis , Colston Elizabeth , Kim Jonghyeon , Throup John , Morita Akimichi
Published: November 2021

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Efficacy and Safety of Tazarotene 0.045% Lotion in White Adults with Moderate-to-Severe Acne
Authors: Del Rosso James , Stein Gold Linda , Tyring Stephen , Philip Werschler William , Cook-Bolden Fran , Han George , Bhatia Neal , Guenin Eric
Published: November 2021

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Determination of the Area of Skin Capable of Being Covered by the Application of 250 mg of Tirbanibulin Ointment, 1%
Authors: Dunn Austin , Han Haowei , Gade Anita , Berman Brian
Published: November 2021

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Therapeutic Recommendations for the Treatment of Toenail Onychomycosis in the US
Authors: Lipner Shari , Josepth Warren , Vlahovic Tracy , Scher Richard , Rich Phoebe , Ghannoum Mahmoud , Daniel Ralph , Elewski Boni
Published: November 2021

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CLINICAL AND EPIDEMIOLOGICAL FEATURES OF OVARIAN NEOPLASMS IN GRODNO REGION
Authors:   Grodno State Medical University, Grodno, Belarus, Savanevich E. L. , Harelik T. M. ,   Grodno University Clinic, Grodno, Belarus, Miklashevich F. S. ,   Grodno University Clinic, Grodno, Belarus, Keda V. V. ,   Grodno University Clinic, Grodno, Belarus, Shulga A. V. ,   Grodno State Medical University, Grodno, Belarus
Published: November 2021

Background. When providing specialized medical care and planning preventive measures, analysis of epidemiological data is instrumental in determining what should be done to reduce morbidity and mortality from ovarian malignant neoplasms (OMNs) within the given scenario. Purpose of research. To study the epidemiological situation with OMNs in the Grodno region. Material and methods. The OMN incidence and indicators of the quality of oncological care in the Grodno region were analyzed according to the data obtained from the Belarusian cancer registry. Results. Since 2007, the OMN morbidity and mortality rates have been relatively stable. In most cases, the diagnosis of malignant ovarian pathology has been based on the results of a pathomorphological investigation. The histological variant of the neoplasm significantly affects the prognosis for life. The most common neoplasms are serous ovarian carcinomas (69%). Neoplasms of non-epithelial origin occur in 8% of all cases. About 16% of women have multiple primary neoplasms with ovarian involvement. In most cases of metachronous development of polyneoplasia the ovarian neoplasm occurs last. The analysis of the age-specific morbidity showed that OMN was most often (52%) diagnosed at the age of 46-65 years. During the study period, about 70% of neoplasms were diagnosed at a later stage, 10% of patients were incurable and received only symptomatic therapy. The indicators of the quality of oncological care demonstrate an increase in the number of cases diagnosed at an early stage. In 2019, in the Grodno region, OMNs of stage I-II were diagnosed in 42% of patients. Conclusion. To improve oncological care for the population and reduce morbidity and mortality from OMNs, it is necessary to develop and implement a set of measures aimed primarily at early diagnosis of the disease and prevention of neoplasm development in the case of primary multiple forms.
RENAL INVOLVEMENT IN PRIMARY SJOGREN’S SYNDROME (CASE REPORT)
Authors:   Grodno State Medical University, Grodno, Belarus, Ausianik E. S. , Zhigaltsov A. M. ,   Grodno State Medical University, Grodno, Belarus, Luchko V. S. ,   Grodno University Clinic, Grodno, Belarus
Published: November 2021

This article presents a clinical case of primary Sjogren's syndrome with a detailed description of the clinical and laboratory dynamics of the disease and its extraglandular manifestations based on the analysis of the data obtained during the patient's hospitalizations in the rheumatology department of the Grodno University Clinic in the period from March 2018 to June 2021.
ANAMNESIS MORBI OF DOCTOR FREUD: PSYCHO-HISTORICAL ANALYSIS
Authors:   Grodno State Medical University, Grodno, Belarus, Assanovich M. A.
Published: November 2021

Sigmund Freud is known as a creator of psychoanalysis, developmental theory and models of personality. Freud's personality, his life story invariably attracts scientists, researchers and practitioners. This article is devoted to the history of Freud's illness, which lasted for 16 years, from 1923 until his death in 1939. Freud suffered from cancer of the upper jaw on the right. An attending physician who performed many operations and prosthetics for Freud was oral surgeon Hans Pichler. Freud bravely endured suffering of the illness. Despite the pains and difficulties in functioning, he continued to work on scientific works and receive patient visits. On September 21, 1939, family doctor Max Schur, at Freud's request, performed euthanasia by injecting a lethal dose of morphine. Among the factors that influenced Freud's decision to be euthanized, the hypothesis of loss of the meaning of further suffering is considered. The concept of meaning is implicitly embedded in understanding of functioning of the Ego in structural model of personality developed by Freud.
Rebuilding a Smart and Sustainable Human Society for the World
Authors: Richard Renaud
Published: November 2021

A bit under 10 years: That’s what it took engineers and project managers to bring some human beings to the Moon in the 60’s. That’s also the time we have to act and rebuild a smart and sustainable human society for the world, and one good indicator for this is reaching the UN’s Sustainable Development Goals by the year 2030. The Sulitest’s matrix gives an excellent structure to explain the current situation and share information in a structured and helpful way; a way in which all can find an answer to this key question: “What can YOU do NOW to rebuild a smart and sustainable society for the world?” The Framework for Strategic Sustainable Development, also known as The Natural Step Framework, is the best approach I’ve found to help create needed systemic and strategic changes. Examples from the business or scientific areas can shed light on how to achieve this incredibly needed change to discuss the role of technology, and to explore how systems change and can be transformed. In this paper, I’ll share some of the experience and learnings I’ve gained over the last 20 years, trying to acce lerate change towards sustainability. I’ll share the fact that it’s fun and motivating, as well as an incredible opportunity for all, even if it’s not necessarily always easy like most good things which do require efforts to reach. And for all the ones who won’t be able to read further: If not now, when? If not here, where? If not you and I, who?
Understanding College Students’ Phone Call Behaviors Towards a Sustainable Mobile Health and Well-Being Solution
Authors: Kim Yugyeong , Vhaduri Sudip , Poellabauer Christian
Published: November 2021

Durante la transición de la escuela secundaria a la vida universitaria en el campus, un estudiante deja su casa y empieza a enfrentarse a enormes cambios en su vida, como cono cer gente nueva, mayores responsabilidades, estar lejos de la familia y retos académicos. Estos cambios provocan un aumento del estrés y la ansiedad, lo que afecta a la salud y el bienestar del estudiante. Con la ayuda de los smartphones y su enriquecida colección de sensores, podemos monitorizar continuamente varios factores que afectan a los patrones de comportamiento de los estudiantes, como las conductas de comunicación asociadas a su salud, bienestar y éxito académico. En este trabajo tratamos de evaluar los patrones de comunicación de los estudian tes universitarios (en términos de duración y frecuencia de las llamadas telefónicas) que varían a través de varios contextos geográficos (por ejemplo, dormitorios, clases, comedores) durante diferentes momentos (por ejemplo, épocas de un día, días de una semana) utilizando técnicas de visualización. Los resultados de este trabajo ayudarán a fomentar el diseño y la realización de intervenciones sanitarias basadas en los teléfonos inteligentes; de este modo, se ayudará a los estudiantes a adaptarse a los distintos cambios en sus vidas.
Prevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. Standards and real clinical practice
Authors: Maksimova Marina Yu. , Fonyakin Andrei V. , Geraskina Liudmila A.
Published: November 2021

The article outlines aspects of the current state of the problem of the priority choice of an oral anticoagulant for indefinite prevention of stroke and systemic thromboembolism in patients with atrial fibrillation. The advantages of direct oral angicoagulants over warfarin are presented, as well as a comparative analysis of the individual characteristics of the main direct oral angicoagulants from the point of view of personification of preventive therapy in accordance with modern treatment standards. The efficacy and safety of oral anticoagulant therapy has been reviewed in terms of the net clinical benefit. Particular attention is paid to the age-related aspects of choosing an anticoagulant for indefinite prophylaxis; an assessment of anticoagulants is presented in accordance with the FORTA concept, which regulates the use of drugs in elderly patients. In conclusion, recommendations are formulated for the choice of an anticoagulant in patients with atrial fibrillation in the most common clinical situations. As a general rule, the choice of a particular drug should be individualized based on risk factors, tolerability, net clinical benefit, patient preference, potential adverse interactions, and other clinical characteristics.