bluuebunny/crossref_metadata_2025 huggingface dataset:
Addiction, Trauma, Attachment and Dissociation: A Treatment with Limbic Psychotherapy®
Authors: MAYER Bernard
Published: January 2025

Within the range of methods amalgamating restricted verbal and non-verbal tactics, integrative therapies imbued with the complex neurophysiological facets of the condition present the best prospects. At the junction of physical and psychological dimensions, these "bottom-up" methodologies possess a distinct ability to activate the patient's neurophysiological reserves, while guarding against any susceptibility to suggestion on the part of the therapist. Targeted manual interventions, previously employed in TICE® [12], reinforce the initial effects, which fundamentally derive from the patient's innate self-healing capacities. The blockages arising from double or triple binds, often including those of a higher order, maintain this deregulated state of functioning in order to survive, because this is how the patient's nervous system was able to respond at the time of his or her trauma, as Pierre Janet already stated in the 1890’s : this constitutes the very essence of Limbic Psychotherapy®, an approach refined over decades of clinical experience with patients. Limbic Psychotherapy® regulates the limbic system by intervening directly at the neurophysiological level, in particular on the balance between the ventral and dorsal vagal pathways of the autonomic nervous system, as described in S. Porges' model. As a result, Limbic Psychotherapy® is both a psychotherapy and a neurotherapy, and is particularly effective in cases of structural and, above all, functional dissociation [33]. A clinical framework ideally suited to treating dissociative states, chronic stress, persistent pain, digestive problems, addictions and trauma. Thanks to the application of double tuning and specialized somatic interventions, the regulation of sympathetic/parasympathetic responses often begins as early as the first session, offering immediate relief to the patient.
Money sign as a legal means of payment and an object of civil rights
Authors: Babaskin Anatoly
Published: January 2025

The statistics have identified penny marks as a legal payment method and an object of civil rights. On the basis of the analysis of the norms of the legislation of Ukraine, doctrinal sources, the general characteristics of monetary signs in civil law are provided, the place of monetary signs in the system of objects of civil rights, etc. is determined. In the course of the research, the author determines the economic and legal functions of money signs. Based on the conducted research, the author draws the following conclusions.

1. The absence of norms in the legislation of Ukraine that would imperatively prevent the situation when payments for significant amounts were made in coins is a shortcoming of the legislation of Ukraine that needs to be eliminated.

2. Payment tokens have the economic functions of a means of circulation, payment, accumulation, measure of value, as well as the main legal function — a legal means of payment.

3. Money signs are symbolic or fiat money, due to the lack of their provision by any monetary standard.

4. Although money is a separate object of civil rights, diﬀerent from things, the law extends the legal regime of property to banknotes, which indicates the need for further research into this legal phenomenon.

5. The provisions of the law, which define currency signs as an «unconditional obligation of the NBU», should be understood as a public legal obligation of the state regulator aimed at ensuring the stability of the purchasing power of the hryvnia and the functioning of money circulation on the territory of Ukraine.

Key words: money, cash, cashless money, unprepared money, digital money, legal means of payment, bank, non-banking payment establishment, a thing, obligation, right of demand.
Problems of applying legal mechanisms for housing construction ﬁnancing
Authors: Venetska Marina
Published: January 2025

The article is devoted to the issues of distinguishing the legal mechanisms of housing construction financing, which are used in the activities of construction financing funds and joint investment institutions (JII).

It is argued that the specified legal mechanisms are diﬀerent and cannot be applied together — by one business entity, first of all, due to the fact that the subjects of relations arising from the application of these financial and legal mechanisms are legal entities with a special status, that diﬀerent types of licensed activity on the capital markets, and which operate on the basis of special laws, the application of which has priority over general legislation.

On the basis of the analysis of current legislation, the conclusion is drawn that the legal mechanism of investment and financing of housing construction with the involvement of JII can be carried out only in accordance with the special legislation regulating the activity of JII , and should include the attraction of investors’ funds through the sale of CII securities and further financing of construction housing at the expense of such funds with the subsequent sale of the built housing to buyers with the purpose of obtaining income in the interests of the participants, or the sale of the invested housing to its participants in the ways provided for by the legislation on the JII (liquidation of the JII and distribution of assets, redemption of own securities, etc.).

At the same time, the status of funds received by JII from counterparties — investors under investment contracts cannot in any way be considered joint investment funds, since such investors did not purchase JII securities and did not become JII participants. According to the results of the conclusion of these contracts, a person who contributes funds to the account of investment funds does not become a member of the JII but actually transfers funds for the construction of real estate on the basis of investment contracts, which may be declared invalid due to defects in the subject structure of the transactions.

Key words: investments, investment contracts, construction financing funds, joint. investment institutions, housing construction financing.
Justice & fairness: the relationship and the corruption factor
Authors: Kvasha Oksana
Published: January 2025

The article analyzes the concepts of justice and fairness. The highest level of corruption in Ukraine, according to ordinary citizens, scientists, and experts, is precisely in the sphere of justice. The criminogenic basis of widespread corruption in Ukraine is malfeasance in the judicial system of Ukraine. Such actions of judges provide an opportunity for many corrupt persons to avoid punishment for corrupt actions. Since justice naturally includes «justice» as an imperative component, the expediency of using the concept of «fair justice» in scientific investigations should be questioned. At the same time, the formula «justice = justice» does not work in Ukraine.

And corruption is the main negative factor of this situation. Therefore, in the Ukrainian information space, we quite often come across the wording «fair justice», which emphasizes the problems of modern justice in Ukraine (for example, the USAID project
«Fair Justice»). Recognizing the protection of the rights and freedoms of every citizen of Ukraine by a fair court as an absolute, it should be noted that the concepts «right to a fair trial» and «principle of natural justice» are consistent. Justice is a universal natural idea embodied in the legal system of any social legal state. Justice, by its very nature, means that the violated right, justice, is restored. Therefore, justice during the war is first and foremost a fair punishment for both the Russian occupiers and the traitors of Ukraine, the inevitability of responsibility for those who betrayed their Motherland. At the same time, unfair justice against corrupt oﬃcials in state authorities, its selectivity, in the conditions of war and post-war reconstruction of the country, can cause devastating consequences for the state. There must be a systematic approach, the political will of the state leadership, the inevitability of responsibility for everyone without excluding persons involved in corruption.

Key words: justice, fairness, right to a fair trial, corruption, war crime, collective victim, court decision, purpose, method, principle, rule of law, legality, access to justice, national security, equality before the law.
Application of information systems and databases in pretrial investigation
Authors: Nersesyan Armen
Published: January 2025

In the modern conditions of the development of the information society in all areas of human life, the application of achievements and developments of scientific and technical progress, artificial intelligence becomes necessary in the implementation of all, without exception, the directions of the state policy of Ukraine. The field of criminal justice was no exception. But regulation at the legislative level of the use of information systems and databases in pre-trial investigation does not mean the absence of problems during the practical implementation of the legislation on the use of the latest information technologies in the specified field.

The purpose of this study was to identify the problems of using information systems and databases in pre-trial investigation and propose measures to solve them.

The generalized databases used in the pre-trial investigation are: information and search systems for forensic purposes (forensic registration); information and search systems for registration of citizens of general social purpose; corporate information and search systems; information systems that appeared under martial law: the information system «Book of Executioners of the Ukrainian People», the analytical application «War Criminals of the russian federation», online platforms for recording the crimes of the Russian Federation against the civilian population of Ukraine.

These include: insuﬃcient regulatory regulation of the creation of databases and their use; insuﬃcient protection of such data from illegal use or theft; the need for the latest software and technical support; insuﬃcient preparation of specialists. In order to solve these issues, it is proposed to: develop a regulatory and legal mechanism to ensure the creation and use of databases and the security of the information contained in them, by providing appropriate authorization documents to law enforcement oﬃcers and establishing responsibility for their unauthorized use or theft; personnel professional training and retraining of specialists who carry out pre-trial investigation and software and technical support of the needs of law enforcement oﬃcers in this area; establishment and development of international cooperation on information exchange through the creation of joint databases with access to law enforcement oﬃcers of diﬀerent countries. This will make it possible to significantly increase the eﬃciency of the use of information systems in pre-trial investigation, which will contribute to the implementation of the state policy on fighting crime in the country.

Key words: information system, database, pre-trial investigation, criminal proceedings, criminal justice, information society, implementation of technologies, inquiry, pre-trial investigation, information technologies, investigative activity, criminal justice, digitalization.
The principle of prohibition of the threat of force from the position of the UN International Court of Justice
Authors: Kononenko Valerii
Published: January 2025

The principle of prohibition of the threat of force in relations between states is established in Art. 2(4) of the United Nations Charter. This principle contains a double prohibition: it requires states to refrain from the use of force and any provocations that could potentially lead to the use of force. The principle of non-use of force is an imperative norm of international law (jus cogens). As an exception, threats can be considered as actions of self-defense and/or as defensive counter-threats.

The political leadership of the Russian Federation announced «demilitarization» and «denazification» as the oﬃcial goal of the Russian army’s invasion of Ukraine. Instead, almost forty years ago, the UN International Court of Justice expressed its position on this issue. The court noted that a state’s choice of its ideology or political system does not give another state the right to interfere in its internal aﬀairs.

Militarization of a state cannot justify the use of force by another state. In international law, the level of armament of a sovereign state is regulated in a contractual or other normative form. This principle applies to all countries without exception.
The International Court of Justice, like the UN as a whole, is not an eﬀective mechanism for ensuring compliance with the principles of prohibition of the threat of force and its use.

Actions related to looting, seizure and exploitation of natural resources committed by military personnel on the territory of another state are a violation of international obligations on the part of the state to which they are subordinate.
Actions of a military nature directed against another state on its territory, in particular, occupation and active support to irregular anti-state formations operating on the territory of such a state, are a violation of the principle of non-use of force in international relations and the principle of non-interference in the internal aﬀairs of states.

The question of the admissibility of a threat as an act of self-defense and whether defensive counter-threats should be considered nonviolent acts of self-defense requires further study.

Key words: the principle of prohibition of the threat of force, demilitarization, denazification, the International Court of the United Nations, aggression, jus cogens.
Humanization of society as a priority of modernization of humanitarian policy of Ukraine
Authors: Horbatenko Volodymyr
Published: January 2025

The process of humanizing society as a priority for the modernization of Ukraine’s humanitarian policy is analyzed. The concepts of «humanization of society» an «humanitarian policy» are considered in the context of modern needs, and their expanded interpretation is formulated. The main directions of ensuring the process of humanization of society are substantiated, which include: policy reorientation to real human needs; humanization of the state administration system and the activities of its subjects; realization of the humanistic potential of science and education.

It was concluded that the humanitarian policy of Ukraine at the current stage of national development requires the preservation of a strong state, strong by the strict limitation of state structures by law, legal frameworks, and the level of real protection of a person’s life, his rights, property and interests.

It was concluded that the humanization of society at the current stage of Ukraine’s national development requires the preservation of the state, which is characterized by the strict limitation of state structures by law, legal frameworks, and the level of real protection of a person’s life, rights, property and interests. From a humanistic point of view, the priority role in a democratic country should belong to civil society, which is independent to the extent that the state is tolerant of such independence. Viable and eﬀective in the modern conditions of the development of the state administration system should be considered a functional approach, which means the distribution of responsibilities and powers in an integral social organism, subject to their coordination, as well as a communicative approach as a specific means of interaction, with the help of which the purpose of the community is clarified, the common interests of the subjects of interaction are implemented, common and binding rules of conduct are developed. Science and education should orient a person to the continuity of the educational process and the limitlessness of scientific knowledge of the surrounding world.

The task of this inseparable system is to direct the state and society to self-improvement and innovative development, create prerequisites for the existence of various human manifestations, readiness for communication with representatives of other cultures, the ability to creatively master a complex and partly unpredictable reality, the ability to survive during changes, war disasters and other social upheavals.

Key words: humanization of society, humanitarian policy of Ukraine, human dimension of politics, public administration system, science and education.
The EU Sanctions Policy: the Destructive Inﬂuence of Eurosceptics’ Personal Factors
Authors: Yavir Vira , Zubrytska Liudmyla , Alimov Anton
Published: January 2025

Introduction. The peculiarities of the EU’s general sanctions policy are analyzed. Particular attention is paid to the destructive impact of irrational personal factors of eurosceptic leaders on a critical area of EU foreign policy — the development of sanctions policy, which weakens EU unity, slows down the response to crises and reduces the ability to respond. The authors oﬀer recommendations for creating a more transparent mechanism for making sanctions decisions.

The purpose of this study is to determine the destructive impact of personal irrational factors of Eurosceptics on the adoption of sanctions in the EU. To explain the personal factors several methods are used: framing theory and the theory of bounded rationality. Framing looks at value constraints and the impact of the way some European politicians frame the issue on the adoption of sanctions. In contrast, the theory of bounded rationality is used to explain possible limitations in the rational thought process and to express the positions of European politicians that influence the adoption of sanctions policies.

Conclusions. It is founded out, that personal factors of Eurosceptic leaders can seriously influence the EU’s sanctions policy. And not only on the issue of sanctions, but also on the entire EU foreign policy, blocking, in particular, the adoption of aid to countries. The limited rationality and value biases of some radical European politicians significantly limit the ability to respond quickly and make the necessary decisions. It is worth considering the factor of elections in the EU and the European Parliament, which may result in more radical and Eurosceptic parties coming to power. The growing popularity of Eurosceptics could lead to the formation of an anti- European coalition of leaders within the EU, which would jeopardize the integrity and unity of the EU, in particular on the issue of sanctions policy.

Key words: European Union, EU foreign policy, EU sanctions policy, sanctions, euroscepticism.
The Issue of Exercising the Right to Alternative Military Service During a State of War and Mobilization
Authors: Terletsky Roman
Published: January 2025

Abstract: This article investigates the issue of exercising the right to alternative military service in Ukraine during a state of war and mobilization.

It has been emphasized that after Ukraine declared its independence, laws on religious freedom, as a subjective legal right, and religious organizations, as instruments and systems for meeting religious needs, have occupied a significant place. The main laws, subordinate acts, and decrees ensuring the right to religious freedom in Ukraine have also been analyzed, including the Law of Ukraine No. 1975-XII of December 12, 1991, «On Alternative (Non-Military) Service.» An analysis of the eﬀectiveness of the Law of Ukraine No. 1975-XII of December 12, 1991, «On Alternative (Non-Military) Service,» and the mechanisms for its implementation in practice by executive authorities during a particular period in the state's history has been conducted.

It has been noted that in Ukraine, two international legal documents are in eﬀect, according to which the State of Ukraine guarantees its citizens the right to freedom of conscience and religion: the Convention for the Protection of Human Rights and Fundamental Freedoms and the International Covenant on Civil and Political Rights. It is observed that relying on the provisions of these documents, Ukraine is obligated to ensure the right to alternative military service, regardless of any internal legal regime.
The verdicts of the courts in cases of charges related to the commission of a crime under Article 336 of the Ukrainian Criminal Code, specifically, evading conscription during mobilization due to religious beliefs, have been analyzed. The emphasis has been placed on the fact that, in the absence of clear legal provisions, Ukraine experiences the application of precedent law.

It has been observed that to prevent the escalation of religious hostility during times of military conflict and to avoid unwanted legal actions, it is necessary to ensure international standards for the protection of human rights, including freedom of conscience and religion, in the sphere of military duty. To achieve this, amendments should be made to the Law of Ukraine «On Alternative (Non-Military) Service» to define the procedure for directing citizens to alternative service during mobilization and the conscription of Ukrainian citizens for compulsory military service during a special period.

Key words: religion, freedom of religion, freedom of conscience, special period, state of war, mobilization, principles of equality, religious organizations, international legal documents, alternative military service, judicial precedent, law eﬀectiveness.
Comparative analysis of the resolution and prevention of judicial error in diﬀerent legal systems
Authors: Dydikov Andriy
Published: January 2025

This article analyses the experience of countries belonging to diﬀerent legal systems in resolving and preventing miscarriages of justice. The aim of the study is to determine whether the methods and ways of preventing and overcoming miscarriages of justice in countries belonging to a particular legal family can be applied to Ukrainian justice. The author determines that no special study of the issue of miscarriage of justice in diﬀerent legal systems has been carried out in the national science, and therefore there is a need to study this issue.

In order to characterise miscarriages of justice in diﬀerent countries, the author reveals the specific features of four legal families: Romano-Germanic, Anglo-Saxon, religious and traditional. Based on the results of the analysis, the author concludes that not all foreign experience of resolving and preventing judicial errors can be implemented into Ukrainian legislation. In particular, this is due to the specifics of legal understanding inherent in a particular legal family, as well as the level of legal awareness of the population.

Given the conclusions reached by the author in the article, an eﬀective way to overcome miscarriages of justice is pre-trial and judicial dispute resolution with the involvement of a mediator, which is actively used in religious and traditional countries. In his opinion, the institute of reconciliation should be actively introduced into national legislation.

In addition, the article emphasises that enshrining the principle of consistency of case law of higher courts at the legislative level, based on the Anglo-Saxon «stare decisis», may reduce the quantitative indicator of miscarriages of justice in Ukraine. The author also justifies that, in order to avoid judicial errors by national courts, there is a need to introduce a court for minor cases, similar to Israel, as well as to introduce the positions of temporary military judges, following the example of common law countries.

Key words: miscarriage of justice, legal family, judicial enforcement, source of law, understanding of law.
Heoretical basis of the principles criminal law of Ukraine
Authors: Golub Yana
Published: January 2025

The article researches theoretical approaches to understanding the principles of law in criminal law science. It is the principles on which law is based in general that ensure the system of law and its potential. The principles of criminal law find their constitutive (mandatory) manifestation in the norms of the criminal law in accordance with the essential legal nature of these fundamental principles of law, and, of course, these provisions must be taken into account during lawmaking and law enforcement. This is an axiom for each and every branch of law, including criminal law. At the same time, a single coherent doctrine of legal principles has not yet been created, which would form the basis of the development of branch principles. In the hierarchy of principles of modern criminal law of Ukraine, justice should be at the top.

One of the main properties of the principles of law is their understanding as the spirit of law, and therefore the justified expediency of their direct application to fill the gaps in criminal law or in the situation of overcoming illegal criminal law. The principles of law are a guide for the law enforcer in the situation of legislative discretion or illegal law. Unlike the draft Criminal Code of Ukraine, the current Criminal Code of Ukraine does not contain a separate section devoted to the principles/general principles of criminal liability. At the same time, it would be an exaggeration to claim that the current criminal law is completely devoid of fundamental principles of law.

Therefore, understanding the essence and meaning of the fundamental principles of law within one or another branch of law has not only theoretical, but also purely practical significance.

Key words: principles of law, criminal law, theoretical foundations, legal principles, branch principles, justice, system of principles, natural law, positive law, hierarchy, non-legal law, criminal responsibility.
Application of law: towards the problem of terminological deﬁnition of the concept
Authors: Teptiuk Maksym
Published: January 2025

The article, dedicated to the issue of law application in Ukraine, examines the pressing question of the quality of legal regulation. It emphasizes the importance of not only developing and adopting quality laws but also their proper application in practice, which is key to the eﬀectiveness of the legal system. The article highlights that correct application of laws can compensate for certain deficiencies, while improper application can undermine their legal significance.
Attention is drawn to the absence of specialized scientific research on the issue of law application, although the problem of legal application has long been a subject of study in legal science. The article cites works of scholars who have researched this issue at various stages.

The main goal of the article is to illuminate the issue of the absence of a clear and unambiguous understanding of the concept of «application of the law» in the scientific community. The authors argue the necessity of clarifying the methodological aspects of developing and formulating this concept.

The article analyzes the broad use of the term «application of the law» in legal practice, particularly in the context of the Criminal Procedure Code of Ukraine, as well as in court decisions, scientific-practical commentaries, and methodological recommendations. Special attention is given to the analysis of cases of applying legal norms, raising questions about the diﬀerences between the concepts of «application of the law» and «application of a legal norm».

Considering the use of the term «application of the law» in general explanatory dictionaries and specialized literature, the authors note its absence in legal terminological dictionaries and legal encyclopedias. Examples are provided from educational and scientific literature, where the concept of «application of the law» also has not received adequate representation.

The author concludes that in legal theory, the concept of «application of the law» as an independent subject of study does not yet exist. He emphasizes the urgent need for a scientific analysis of this concept as a component of the legal regulation process, which can help solve problems in legal practice and contribute to improving the legal regulation of social relations in Ukraine.

Key words: law, legal activity, operation of law, application of law, legal norm.
HONGKONG SULAWESI: Penyelundupan Kopra di Tolitoli Selatan, 1950-1967
Authors: Lumangino Wilman D. , Fatma Fatma , Hadara Ali , Aditama Muhammad Reza
Published: January 2025

Artikel ini menjelaskan kondisi ekonomi dan aktifitas smokol serta implikasinya di Pantai Barat Sulawesi Tengah. Sejauh ini historiografi Pantai Barat Sulawesi Tengah pada masa transisi hanya berkutat pada konflik politik pemerintah dan DI/TII. Padahal pada saat yang sama, aktifitas penyelundupan juga mencapai masa keemasannya di wilayah tersebut. Periodisasi studi ini dimulai 1950-1967 berdasarkan populernya penyelundupan di Tolitoli Selatan. Penyebab utamanya yaitu harga kopra yang rendah, dan produksi yang melimpah. Serta adanya jaringan perdagangan lama yang dilalui dari Teluk Dondo ke Tawau, Brunei, dan Singapura. Oleh karena itu, smokol mampu menghadirkan kondisi dan situasi ekonomi baru bagi masyarakat Tolitoli Selatan. Ogotua dan Soni sebagai pusat penyelundupan dilabeli sebagai Hongkong Sulawesi, label ini terkait dengan adanya jaringan pelayaran dan perdagangan ilegal dengan kopra sebagai komoditas dagang utama. Selanjutnya, ketika kembali dari Tawau, para penyelundup membawa barang-barang mewah untuk digunakan sendiri atau dijual di berbagai pasar desa. Ada juga yang ditukar dengan kopra. Melihat peningkatan ekonomi yang terjadi di Pantai Barat Sulawesi Tengah, aparat negara pun ikut melibatkan diri ke dalam aktivitas penyelundupan. Smokol pun menjadi terlihat legal saat itu.
The seven-dimensional universe
Authors: Kesanasetty Sasidhar
Published: January 2025

This paper elucidates the concept of dark energy and the acceleration of the universe through the quantization of space in hidden dimensions, which provides the foundation for gravitational force. Space-time is conceptualized as a four-dimensional elastic grid within a seven-dimensional universe, wherein matter expands concurrently with the universe. Each cube of the grid is considered a quantum of hidden three-dimensional space of Planck volume containing Planck charge, rendering the universe seven-dimensional. The phenomenon of dark energy is attributed to the electrostatic repulsion between Planck charges in each quantum of the hidden space, and the corresponding energy density is correlated with the Hubble parameter H(z), which accounts for the accelerated expansion of the universe and the increase in the relative cosmological potential energy/rest mass of matter. The expansion of space-time is posited to result not from the creation of new space but from the stretching of existing space-time, analogous to an elastic ruler where proper length and volume remain constant. The relative values of the Planck constant, gravitational constant, permittivity of free space, and Boltzmann constant are demonstrated to vary due to the expansion or contraction of space in cosmological and gravitational frameworks but are compensated for by the proportional change in the rest mass. This theory also establishes a framework for the relativistic Newtonian theory of gravity, the respective MONDian (Modified Newtonian dynamics) gravity, identifies a rationale for the transition of Newtonian gravity to MOND at a0, and elucidates the dynamics of galaxy clusters without invoking dark matter.
The Relationship Between Family Support and Medication Adherence in Type 2 Diabetes Patients at Cililin Hospital, Bandung, Indonesia
Authors: Kartini Yayu , Tohri Tonika , Warna Mawar Puspa
Published: January 2025

Background: Diabetes mellitus is often called the silent killer and often causes complications for sufferers that require long-term treatment. Family support is the involvement provided by the family to the patient which includes a positive attitude, affirmation and assistance. Compliance is the degree to which patients carry out treatment methods and behavior recommended by health workers. This study aims to determine the relationship between family support and medication adherence to type 2 diabetes mellitus patients at the internal medicine polyclinic of Indonesian Hospital. Methods: Categorical comparative analysis in 2 groups was not paired with a cross-sectional approach. The population in this study is 325 respondents. Sampling was determined using the purposive sampling technique as many as 77 respondents who met the criteria. The instruments in this study used the Nursalam social family support questionnaire and the MMAS-8 (Morisky Medication 8-item Adherence Scale) questionnaire. Data analysis used univariate and bivariate analysis with the Fisher Exact test. Results: The results of the fisher exact test obtained a p-value of 0.00 or <0.05, namely there was a relationship between family support and medication adherence in type 2 diabetes mellitus patients. Conclusion: There is a significant relationship between family support and medication adherence in patients with type 2 diabetes mellitus at the internal medicine polyclinic of Cililin Hospital.
Effectiveness of Snakehead Fish (Channa striata) Snacks in Improving Protein Intake and Albumin Levels in Adolescent Girls at Risk of Chronic Energy Deficiency
Authors: Mustafa Annasari , Soelistyorini Dwie , Pudjirahaju Astutik , Safitri Puput Dewi
Published: January 2025

Background: Chronic Energy Deficiency (CED) is a condition characterized by long-term inadequate intake of energy and protein, identified through Mid-Upper Arm Circumference (MUAC) measurements with a threshold of less than 23.5 cm. According to the 2013 Riskesdas data, the prevalence of CED among individuals aged 15-19 years in Indonesia was 46.6%, which decreased to 36.3% in 2018 for non-pregnant women. In East Java, the prevalence of CED among 15-19-year-olds was 52.5% in 2013 and 37.73% in 2018. Despite this decline, low albumin levels often signal poor nutritional status, typically resulting from prolonged nutrient deficiencies. Snakehead fish (Channa striata), known for its high protein content, particularly albumin, offers a potential solution for improving protein intake and blood albumin levels among adolescent girls at risk of CED. In this study, snacks made from snakehead fish provide significant protein, including 216.1 kcal and 8.01g of protein (Nugget), 214.88 kcal and 13.76g of protein (Siomay), and 216.4 kcal and 7.8g of protein (Ekado). When combined with vegetables, these snacks are expected to improve nutritional values, especially protein and albumin levels. This study aims to assess the impact of snakehead fish (Channa striata)-based snacks on protein intake and blood albumin levels in adolescent girls at risk of CED. Methods: The study used an experimental, quasi-experimental design with a one-group pretest-posttest approach. The intervention was provided twice a week for 2 months, with monitoring through 24-hour food recall forms and food records. Results: The results showed a significant improvement in protein intake (p = 0.009, paired sample T-test) and blood albumin levels (p = 0.000, Wilcoxon test) after the intervention. Conclusion: Snakehead fish (Channa striata)-based snacks effectively enhance protein intake and blood albumin levels in adolescent girls at risk of CED.
Koinsidensi Vaginosis Bakterial pada Pasien dengan Kandidiasis Vulvovaginalis Kronis
Authors: Pradestine Sesia , Mawardi Prasetyadi
Published: January 2025

Vaginosis bakterial (VB) dan kandidiasis vulvovaginal (KVV) adalah infeksi vagina yang umum terjadi dengan etiologi yang berbeda, namun dapat terjadi bersamaan dan mempersulit pengobatan. Ketidakseimbangan dalam mikrobiota vagina menjadi ciri khas VB, sedangkan KVV adalah infeksi jamur yang disebabkan oleh Candida spp. Interaksi antara infeksi ini dapat mempengaruhi hasil pengobatan.  Kami melaporkan seorang wanita berusia 19 tahun yang datang dengan keputihan berwarna putih kental, berbau, dan gatal. Dia memiliki riwayat gejala yang berulang dan sering menggunakan antibiotik. Pemeriksaan fisik menunjukkan beberapa papula dan cairan putih susu. Pemeriksaan mikroskopis menunjukkan adanya pseudohifa, sel tunas, dan bakteri batang gram negatif dengan sel petunjuk. Pasien didiagnosis dengan VB bersamaan dengan KVV kronis dan diobati dengan metronidazol dan flukonazol, diikuti dengan itrakonazol, yang menghasilkan perbaikan. Terjadinya VB dan KVV secara bersamaan mempersulit pengobatan karena mikrobiota vagina yang berubah. Antibiotik untuk VB dapat meningkatkan pertumbuhan Candida, yang menyebabkan KVV. KVV kronis pada pasien membutuhkan terapi antijamur yang lebih lama. Memahami interaksi antara VB dan KVV sangat penting untuk manajemen yang efektif, terutama pada kasus-kasus kronis. Kesimpulannya adalah manajemen VB dan KVV yang efektif secara bersamaan membutuhkan pemahaman yang komprehensif tentang interaksi keduanya dan strategi pengobatan yang disesuaikan. Penelitian lebih lanjut diperlukan untuk mengeksplorasi mekanisme interaksi ini dan meningkatkan pendekatan terapeutik.
Integrated approach with UHPLC-Q-Exactive-tandem mass spectrometry, network analysis, and molecular docking to determine potential active compounds and mechanisms of Rhizoma Musae decoction in osteoarthritis treatment
Authors: Zhang Jian , Shen Wanyan , Liu Fanzhi , He Hehe , Han Shuquan , Luo Lina
Published: January 2025

Objective

This study aimed to identify the potential active compounds in Rhizoma Musae decoction and understand their mechanisms of action in osteoarthritis treatment.

Methods

UHPLC-Q-Exactive-MS/MS technology was used for an in-depth analysis of the chemical compounds present in Rhizoma Musae decoction. A network analysis approach was used to construct a comprehensive network of compounds, targets, and pathways, which provided insights into the molecular mechanisms of Rhizoma Musae decoction in osteoarthritis treatment.

Results

The integrated analysis revealed the presence of 534 chemical compounds in Rhizoma Musae decoction, with 7beta-hydroxyrutaecarpine, 7,8-dihydroxycoumarin, pinocembrin diacetate, and scopoletin being identified as potential active compounds. Potential targets such as GAPDH, AKT1, TNF, IL6, and SRC were implicated in key pathways including MAPK signaling pathway, lipid and atherosclerosis, PI3K-Akt signaling pathway, and IL-17 signaling pathway. Molecular docking studies showed significant binding affinity between the core targets and key components. In vitro cell experiments have demonstrated that RM decoction can enhance cell proliferation and upregulates the expression of TNFα, IL-6, and SRC, while down-regulating the expression of GAPDH and AKT1.

Conclusion

The potential active compounds present in Rhizoma Musae decoction influence specific targets and signaling pathways involved in osteoarthritis pathogenesis, providing new insights for the functional development and utilization of RM.
Multi-Objective Optimization for Green BTS Site Selection in Telecommunication Networks Using NSGA-II and MOPSO
Authors: Babaei Salar , Khalaj Mehran , Keramatpour Mehdi , Enayati Ramin
Published: January 2025

Today, facility location planning primarily pertains to the long-term strategic and operational decision-making of large public and private organizations, and the significant costs associated with facility location, construction, and operation have turned location research into long-term decision-making. Presenting a hub location model for the green supply chain can address the current status of facilities and significantly improve demand coverage at an acceptable cost. Therefore, in this study, a network of facilities for hub location in the service site domain, considering existing and potential facilities under probable scenarios, has been proposed. After presenting the mathematical model, validation was performed on a small scale, followed by sensitivity analysis of the main parameters of the model. Furthermore, a metaheuristic algorithm was employed to analyze the NP-Hardness of the model. Additionally, two metaheuristic algorithms, NSGAII and MOPSO, were developed to demonstrate the efficiency of the model. Based on the conducted analysis, it can be observed that the computational time increases exponentially with the size of sample problems, indicating the NP-Hardness of the problem. However, the NSGAII algorithm performs better in terms of computational time for medium-sized problems compared to the MOPSO algorithm. These algorithms were chosen due to their proven efficiency in handling NP-hard optimization problems and their ability to balance exploration and exploitation in search spaces.
Fast Dynamic Time Warping and Hierarchical Clustering with Multispectral and Synthetic Aperture Radar Temporal Analysis for Unsupervised Winter Food Crop Mapping
Authors: Li Hsuan-Yi , Lawarence James A. , Mason Philippa J. , Ghail Richard C.
Published: January 2025

Food sustainability has become a major global concern in recent years. Multiple complimentary strategies to deal with this issue have been developed; one of these approaches is regenerative farming. The identification and analysis of crop type phenology are required to achieve sustainable regenerative faming. Earth Observation (EO) data have been widely applied to crop type identification using supervised Machine Learning (ML) and Deep Learning (DL) classifications, but these methods commonly rely on large amounts of ground truth data, which usually prevent historical analysis and may be impractical in very remote, very extensive or politically unstable regions. Thus, the development of a robust but intelligent unsupervised classification model is attractive for the long-term and sustainable prediction of agricultural yields. Here, we propose FastDTW-HC, a combination of Fast Dynamic Time Warping (DTW) and Hierarchical Clustering (HC), as a significantly improved method that requires no ground truth input for the classification of winter food crop varieties of barley, wheat and rapeseed, in Norfolk, UK. A series of variables is first derived from the EO products, and these include spectral indices from Sentinel-2 multispectral data and backscattered amplitude values at dual polarisations from Sentinel-1 Synthetic Aperture Radar (SAR) data. Then, the phenological patterns of winter barley, winter wheat and winter rapeseed are analysed using the FastDTW-HC applied to the time-series created for each variable, between Nov 2019 and June 2020. Future research will extend this winter food crop mapping analysis using FastDTW-HC modelling to a regional scale.
Changes in Soil Organic Carbon and Enzyme Activity After Land Use Change in Northeast China
Authors: Wang Yang , Shan Te , Zhang Peng , Li Ming
Published: January 2025

In Northeast China, the establishment of irrigated paddy fields manifests on soil characterized as upland soils. However, the implications of soil conversion from upland soil to paddy soil for soil aggregates, soil organic carbon (SOC), and enzyme activity within soil aggregates remain poorly understood. Exploring the repercussions of soil conversion on SOC is paramount in delineating enhanced strategies for ameliorating soil structure and bolstering organic carbon sequestration within terrestrial ecosystems. Therefore, this study aimed to quantify the impact of land use modifications on SOC content and enzyme activity within soil aggregates. In this study, paddy (rice field) and upland (maize field) plots were selected from Mollisols in Northeast China, which is characterized by akin soil type, level topography, and climatic conditions. The results indicated that microaggregates represented the predominant fraction in both land use types, ranging from 36.96% to 48.99%, with a notably higher proportion in paddy soil compared to upland soil. After 40 years of rice cultivation, a significant decrease of 9.90% and 2.97% was observed in mean weight diameter and geometric mean diameter, respectively. In paddy soils, the SOC content in aggregates of varying sizes had the following order: macroaggregates (26.41 g kg−1) < microaggregates (21.91 g kg−1) < silt + clay (15.55 g kg−1) fractions. Similarly, in upland soil, the highest SOC content was found in macroaggregates, with the following sequence: macroaggregates (21.67 g kg−1) < microaggregates (17.44 g kg−1) < silt + clay (15.03 g kg−1) fractions. β-glucosidase (BG) displayed the highest enzyme activities, with average values of 95.99 nmol h−1 g−1 in paddy soil and 85.34 nmol h−1 g−1 in upland soil. Macroaggregate fractions exhibited the highest BG activity in both soil types (paddy: 112.49 nmol h−1 g−1, upland: 96.71 nmol h−1 g−1). In conclusion, the conversion from upland fields to paddy fields changes the occurrence mechanism of SOC in the aggregate, which is an important way of sustainable C sequestration in cropland ecosystems.
Identification and Characterization of the ROP GTPase Gene Family in Strawberry and the Positive Role of FveROP4 in Fruit Resistance to Gray Mold
Authors: Zhao Shuai , Zhu Baode , Zou Zhijun , Zhai Yushan , Liao Sufeng , Xu Ming , Li Kunyang , Mehmood Nasir , Liao Xiong
Published: January 2025

ROP small GTPases function as signaling hubs that mediate various physiological processes, including plant defense. Their specific roles in strawberry resistance against gray mold remain uncharacterized. In this study, we identified 53 ROP genes across the genomes of six Rosaceae species. Based on sequence homology, they were classified into three distinct phylogenetic clades. Detailed analysis of FveROP proteins revealed the presence of highly conserved catalytic G-domains, which are essential for their GTPase activity. By conducting transient overexpression experiments in strawberry fruits challenged with the gray mold pathogen Botrytis cinerea, we investigated the impact of the FveROP4 gene on disease resistance. The overexpression of both wild-type and constitutively active forms of FveROP4 enhanced resistance against B. cinerea infection. Subsequent analysis revealed that overexpression of FveROP4 and FveCAROP4 genes led to increased accumulation of reactive oxygen species. Moreover, FveROP4 was localized on the plasma membrane, where it interacted directly with FveRBOHF1, corroborating the results obtained through yeast two-hybrid and luciferase complementation imaging assays. The study findings may provide valuable insights for investigating the mechanisms of ROP signaling in regulating the immune response in strawberries and could significantly contribute to strawberry breeding programs aimed at developing new cultivars with enhanced fruit shelf life.
Fish Meal Replacement by Chicken By-Product Meal in Diet: Impacts on Growth and Feed Availability of Juvenile Rockfish (Sebastes schlegeli), and Economical Analysis
Authors: Li Ran , Cho Sung Hwoan
Published: January 2025

A 56-day feeding experiment was carried out to evaluate the effects of substituting fish meal (FM) with chicken by-product meal (CBM) in diets on the growth and feed utilization of rockfish (Sebastes schlegeli). Six experimental diets were formulated to be isonitrogenous and isolipidic. The control (Con) diet included 55% FM. In the Con diet, 10%, 20%, 30%, 40%, and 50% of FM was replaced with CBM, named as the CBM10, CBM20, CBM30, CBM40, and CBM50 diets, respectively. A total of 540 juvenile fish were distributed into 18 tanks (30 fish per tank and 3 tanks per diet) and fed to apparent satiation two times daily for 56 days. The weight gain and specific growth rate of rockfish fed the CBM10 and CBM20 diets were comparable to rockfish fed the Con diet. The feed consumption of rockfish fed the Con and CBM10 diets was significantly (p < 0.001) higher than that of fish fed all other diets, except for the CBM20 diet. However, protein retention, biometric indices, chemical composition, amino acid profiles, and plasma and serum parameters of rockfish were not significantly influenced by dietary FM substitution with CBM. The Con, CBM10, and CBM20 diets showed superior (p < 0.001) economic profit index (EPI) compared to the CBM30, CBM40, and CBM50 diets. Conclusively, FM up to 20% could be substituted by CBM in diets without impairing growth, feed availability, chemical composition, amino acid profiles, and blood parameters of rockfish grown from 2.5 g to 12.5 g. However, the long-term effects of CBM substitution or the potential use of combined CBM and other alternative protein sources for FM in rockfish diets are needed in future.