bluuebunny/crossref_metadata_2025 huggingface dataset:
فاعلية (أنموذج بايبي البنائي) في تحصيل طالبات الصف الخامس الاعدادي في مادة رسم المنظور الهندسي
Authors: Maha Abd- AlSamad Salman
Published: April 2022

يهدف البحث الحالي الى تنمية مهارات طالبات الصف الخامس الاعدادي في مادة رسم المنظور الهندسي. ولدراسةدلك حددت الباحثة بناء خطط تدريسية لمهارات رسم المنظور الهندسي وفق (أنموذج بايبي البنائي). و تم صياغة فرضيتين صفريتين :

لا توجد فروق ذات دلالة إحصائية عند مستوى دلالة (0,05) بين رتب درجات طالبات المجموعتين (التجريبية والضابطة) في تقيم الاداء المهاري (قبليا)ً.

لا توجد فروق ذات دلالة إحصائية عند مستوى دلالة (0,05) بين رتب درجات طالبات المجموعتين (التجريبية والضابطة) في تقيم الاداء المهاري (بعدياً).

 وقد أظهرت نتائج هذه البحث ما يأتي:

فاعلية الخطط التدريسية على وفق (أنموذج بايبي البنائي) في تنمية مهارات رسم المنظور الهندسي لطالبات الخامس الاعدادي- المجموعة التجريبية. والتي كان لها التأثير الإيجابي للوصول الى النتائج المرغوبة.
دراسة بعض الخصائص الميكانيكية والفيزيائية نتيجة اضافة النيكل-المنيوم الى السليكا بطريقة الرش الحراري باللهب
Authors: 1Mohammed Jwair Dathaan  , 2Salih Y.Darweesh
Published: April 2022

تم عمل عينات بأبعاد قطرها 20mm, وارتفاعها 3mm من صفيحة فولاذ نوع 316L حيث ان النماذج حضرت بطريقة الرش الحراري باللهب, تم اخذ نسب مختلفة من مادتي %NiAl وبنسب مختلفة %(0,5,10,15,20,25) وتم اضافتها الى المادة الاساس من السليكا SiO2 وبذلك تكونت عينات سيرمتية (سيراميك+معدن), تم تلبيد العينات عند درجة حرارة 900°C ولزمن ساعتين, واجريت الفحوص الفيزيائية والميكانيكية والتي تم الحصول على افضل النتائج عند القيم المثلى من مسافة رش 16cm, وتلبيد 900°C , ونسبة مزج 25%, ووجد ان الصلادة هي (590Hv) , بينما كانت اقل مسامية هي (4.5%), واعلى قوة تلاصق (38MPa), بينما كان اقل قيمة للبلى هي(0.11), اما النتائج التركيبية والتي تمثلت بفحص المجهر الالكتروني الماسح (SEM) فقد بينت ان افضل النماذج تجانساً تشابكياً هي 25% من المادة المعدنية المدعمة Ni-Al.
دور الرسوم الإيضاحية في تعزيز الثقافة المرئية للطفل
Authors: أ.د.نصيف جاسم محمد  , أ.م.د.اكرم جرجيس نعمة
Published: April 2022

مع ازدياد التدفق المعلوماتي الكبير، والتطور الذي إشتمل الافراد والمجتمعات بفعل ما الت اليه التقنيات الحديثة، فإن مواكبة ذلك تتطلب الكثير من العمل والجهد في سبيل اللحاق بما يستجد، فهناك القنوات الفضائية، والصحف والمجلات والتقنيات الحاسوبية اللوحية، الى غير ذلك، ويبرز من بين ذلك كله الرسوم الايضاحية التي تشكل ركنا مرئيا مطلوبا من قبل الاطفال كونها تتناغم مع حواسهم وميولهم، هذه الرسوم التي تعد من بين تطبيقات التصميم الكرافيكي المعاصر قدمت وتُقدم كل يوم انماطا متنوعة من الحوار المرئي القريب من ذهنية وتصورات الاطفال، اذ يُعْرض من خلالها قصص وحكايات ارشادية متنوعة تعتمد تقنية الايضاح (Illustrations) القريبة من تصورات الأطفال، وتكمن مشكلة البحث في التساؤل الآتي :

ما الدور الذي تقوم به الرسوم الإيضاحية في تعزيز الثقافة المرئية للطفل؟
وعي طلبة الجامعة للحد من اخطار الكوارث وفقا لاطار سنداي الدولي
Authors: م.م.  محمد نجم الدن عبد الله  , أ.م.د. حسين سالم مكاون  , أ‌.د. نادية حسين يونس العفون
Published: April 2022

يهدف البحث الى التعرف على واقع الوعي وفقا لإطار سنداي للحد من مخاطر الكوارث، لدى طلبة جامعة الموصل/ كلية التربية للعلوم الصرفة/ قسم علوم الحياة/ المرحلة الاولى. واستخدم الباحثون المنهج الوصفي لملاءمة طبيعة البحث، اذ يتكون مجتمع البحث من (264) طالبا وطالبة، من المرحلة الاولى قسم علوم الحياة كلية التربية للعلوم الصرفة، وعينة البحث والبالغة (160) طالبا وطالبة، كما قام الباحثون ببناء مقياس الوعي للحد من مخاطر الكوارث المتضمن (68) فقرة، كأداة لجمع البيانات، وتم التأكد من الصدق الظاهري وصدق المحتوى للمقياس والثبات، واستخدمت الوسائل الاحصائية المناسبة، وتم تطبيق المقياس على عينة البحث الاساسية، وبينت نتائج الدراسة ان مستوى الوعي للحد من مخاطر الكوارث منخفض نسبيا، وهذا يرجع الى عدم تضمين ابعاد اطار سنداي المتفق عليه دوليا ضمن المناهج الدراسية، ويوصي الباحثون بأتباع السبل المتفق عليها عالميا ضمن إطار سنداي، ويقترحون إجراء دراسات مماثلة لقياس الوعي في الحد من مخاطر الكوارث لدى الطلبة في مستويات التعليم كافة.
العميد خليل ابراهيم حسين الزوبعي ودوره في وزارة الصناعة 1967-1968
Authors: Ahmed Hatem Taha  , Prof.Dr. Emad NI'MA Al-Abadi
Published: April 2022

تعد دراسة الشخصيات العسكرية والسياسية والفكرية من الدراسات التي تعطي للفرد دور في كتابة التاريخ ، وقد شهد تاريخ العراق المعاصر عدد كبير من الشخصيات البارزة و المؤثرة التي لها دور في احداثه, ومن هذه الشخصيات تبرز شخصية العميد المتقاعد خليل ابراهيم حسين الزوبعي موضوع الدراسة. وتكمن اهمية الموضوع ان العميد المتقاعد خليل ابراهيم حسين من الشخصيات المهمة في تاريخ العراق المعاصر فقد كان له دوره العسكري والسياسي والفكري المميز, اذا انه شغل العديد من المناصب اهمها استيزاره وزيراً للصناعة في 10 تموز 1968 ولغاية 17 تموز 1968 اذ قدم فيها الكثر من المنجزات وسعى جاهداً لتقديم كل ما يملك من خبرات في سبيل الارتقاء بالواقع الصناعي في العراق.
كتابات تاريخية موثقة في تصانيف العلامة نعمة الجزائري (1050-1112هـ/ 1640-1700م)
Authors: Assist. Prof. Dr. FERDAWS   ABDULRAHMAN  KAREEM
Published: April 2022

في الصفحات المتقدمة طاقة خلاقة، نشأت وتعلمت وابدعت وانتجت في عصر وبيئة يكون الخلق والإبداع فيها من عالم الأحلام، لما تراكم في مطباتها من التلف والضعف وتنوعت وتعددت في طريقها العقبات والمعوقات التي حالت بينها وبين سبل التطور والازدهار الحضاري والفكري، ومع اشتداد الأزمات وترادف النكسات، برزت بعض المشاعل الوضاءة لتمنح الفكر العربي الإسلامي روح الديمومة والبقاء والمواصلة، ولو في أضواء خافتة لكي لا تتحول الحياة العربية الإسلامية إلى العدم .     فكان العلامة الأديب المؤرخ نعمة الله الجزائري أحد الأفذاذ الذين ساهموا في مد حلقات التواصل الفكري والثقافي والأدبي والتأريخي في التراث العربي الإسلامي في عصره والعصور التي سبقته للارتباط بعد ذلك بالعصر الحديث.         كان من مبدأ نشوئه إلى آخر عمره مولعاً بطلب العلم ونشره وترويجه، كدوداً لا يفتر عنه ولا يمل، كان في أسفاره يستصحب معه ما يقدر عليه من الكتب، فإذا نزلت القافلة وضعها واشتغل بها إلى وقت الرحيل، وربما يأخذ الكتاب بيده يطالع فيه وهو على ظهر الدابة في المسير، وكان من شدة ولعه من العلم والمعرفة أن قد ساح في كثير من البقاع والبلاد ولم يزل صبياً، وواجه أصنافاً من المشقات والمصائب في سبيل التحصيل حتى بلغ به الحال أنه لم يجد ما يسد به رمقه أو يضيء به سراجه للمطالعة، وكان يواجه الحياة بتصميم عجيب وارادة عالية وعزم لا يفل، دؤوب مثابر، يزداد تعلقاً واعتناء في كتبه، فنبغ في كثير من العلوم والفنون، وصنف في التأريخ والحديث والتفسير والفقه والنحو والأدب، ومعظم مؤلفاته نافعة للناس لأنها تمس حياتهم وتعالج حالهم وسلوكهم وتزرع فيهم حب الفضيلة والخير.
التبئير في روايات حميد الربيعي
Authors: Nora Kamel Ali Al-Husseinawi  , Prof. Dr. Baida Mohy El-Din Al-Dosky
Published: April 2022

ومن خلال تطور مفهوم التبئير نرى إنه قد مر بمراحل متطورة وهذا التطور الذي جرى على كثير من الكتب النقدية والدراسات السردية مما جعله من أبرز المصطلحات المتداولة والمهمة حيث بلغ مركز الصدارة في الدراسات والابحاث وهذا جعل له عدة مسميات ( الرؤية أو وجهة النظر أو المنظور).
The Phylogeography of Rhizophora in Peninsular Malaysia: High Genetic Variation between West and East
Authors: Aboubakr Anwar E.
Published: April 2022

Geographic history of Rhizophora species and hybrid is effect on their genetic structure. In addition, determining population genetic variation is essential for phylogeography research. For this phylogeography investigation, Four natural population of Rhizophora were collected from five different regions in peninsular Malaysia for this phylogeography study. This study aims to evaluate the genetic diversity of Rhizophora species namely Rhizophora apiculata , Rhizophora mucronata , Rhizophora stylosa and hybrid R. × lamarcki and clarify their genetic structure of its populations using Nucleotide polymorphism in chloroplast intergenic spacer between trnL and trnF genes was studied.The populations of Rhizophora species and hybrids were divided into two groups: the east coast populations, which were represented by samples collected from Mersing, Tanjang Piai, and Sedili; and the west coast populations, which were represented by samples collected from Mersing, Tanjang Piai, and Sedili. The population of the west coast was the second cluster. This result was supported by UPGMA analysis using MEGA5 software.
Penyuluhan Hukum Undang-Undang Nomor 11 Tahun 2020 Tentang Cipta Kerja Kepada Milenial dan Pelaku Usaha Mikro Kecil Menengah
Authors: Hukunala Sandy Victor
Published: April 2022

Introduction: The COVID-19 pandemic has had a negative impact on the business world and the world of work. A shattered economy and massive layoffs are serious problems. Law Number 11 of 2020 concerning Job Creation is here to answer that challenge. With a focus on simplifying regulations so that investment and the business world can develop which of course has an impact on employment.Purposes of Devotion: The purpose of this service is to provide legal understanding and awareness to the millennial generation who are the active workforce and the majority of Micro Small Medium Enterprises actors today regarding the convenience, protection and empowerment provided by the government through Law Number 11 of 2020 so as to rediscover enthusiasm and confidence in the business world and work. Method of Devotion: The method used in this service is the educational method, namely conducting legal counseling regarding the substance of Law Number 11 of 2022 concerning Job Creation and several derivative rules or their implementation.Results of the Devotion: This legal counseling activity had a positive impact on the millennial generation and Micro Small Medium Enterprises actors in the Small Hative Village who had the opportunity to attend. This can be seen from the active response through the questions asked by the counseling participants. So we hope that understanding this legal counseling material can not only foster enthusiasm and motivation for participants but also raise awareness and legal culture which can later be implemented in the business world and the world of work.
Atención plena (mindfulness): por qué es posible que funcione y por qué es seguro que triunfe
Authors: Errasti-Pérez José , Al-Halabí Susana , López-Navarro Emilio , Pérez-Álvarez Marino
Published: April 2022

La atención plena (mindfulness) ha desbordado el ámbito clínico y comienza a aplicarse con entusiasmo en la escuela, el deporte o la empresa. La sospecha de que estamos ante una intervención que, aunque probablemente eficaz, tenga un tamaño de efecto pequeño, lo que obliga a realizar investigaciones con gran rigor. Así, solo conociendo los procesos psicológicos implicados en la atención plena podremos tener una visión más realista de su utilidad ante los diferentes problemas. Ante esto, ¿cómo explicar el extraordinario éxito que está obteniendo en Occidente la atención plena, tanto a nivel académico como mundano? Se presentan tres principios conductuales que se practican durante el entrenamiento en atención plena y se denuncia su uso ideológico, que aparece enmarcado, no en la mística existencial ni en el conductismo contextual, sino en la psicología positiva y su agenda neoliberal.
THE IDEAS OF EDUCATIONAL STEM-STEAM-PROJECTS
Authors: Shybka O. S. , Shybka H. I.
Published: April 2022

The modern requirements for reforming all sectors of Ukrainian education include, among other things, the active use of STEM-STEAM technologies. On the one hand, this approach provides a lasting interest of students in the conscious choice of future profession STEM-profile. On the other hand, the use of innovative educational technologies motivates teachers themselves to acquire new knowledge and skills. It is impossible to be an expert in all subjects of the school program at the same time. This is not the case when one teacher is forced to teach several unrelated subjects. But even the narrow specialization of the teacher can be an obstacle in finding interesting topics for student learning projects. A geography teacher cannot always come up with a project topic that combines philological subjects, exact sciences and computer science. Therefore, we offer some ideas for the implementation of STEM and STEAM projects that can inspire teachers to search for new topics in classroom, extracurricular and extracurricular activities. An important feature of the proposed ideas of STEM and STEAM projects is that their implementation does not require the presence in the school of a robotic complex or set of LEGO. According to the author, to narrow STEM-technologies to robotics is extremely wrong. STEM-technologies in education are, firstly, the integration of courses, topics and subjects, and, secondly, the project activities of students. And the project should include all obligatory stages: the formulation of the task, drawing up a work plan, the work according to the plan, checking the result of work in accordance with the formulated task, the presentation of the obtained results. The proposed ideas were embodied in different years in the circle of astronomy and information technology of the city station of young technicians of the Dnieper in the form of competitions, open classes, presentations within the school scientific society and more. In order not to impose a specific form of implementation of the proposed topics, the author presents them in plain text, rather than in the form of a synopsis.
Oligopleiodontia of the mandibular anterior segment
Authors: Muttineni Navya , Manasa N , Turimella Sindhura , Badipati Ramya Bharathi , Lalitha Garepally
Published: April 2022

Esthetic management of supernumerary tooth   is encountered routinely in our day to day practice. When such a case presents with underlying periodontal problems like gingival recession, its management requires a multidisciplinary approach for a long term successful outcome. This case report presents one such case where a connective tissue graft with an epithelial collar was placed using modified envelope flap technique for correction of gingival recession which preceded esthetic management of the ST in oligopleiodontia patient. Esthetic management was done by direct composite veneer. Direct placement of composite veneers has greater control, require a conservative removal of tooth structure and can be easily repaired and modified at any stage. 2 year follow up showed optimal root coverage and appreciable esthetics.
Nutritional and environmental epigenetics effects on human health and diseases
Authors: Almalki Waleed Hassan , Alshehri Ahmed , Almatrafi Basel Saeed , Alasmari Mohammed Abdullah , Jammal Jawad Ali , Alandijani Eyad Ahmad
Published: April 2022

Both industrialized and developing nations see an alarming rise in adult-onset illnesses such as T2D and CVD. According to human and animal research, prenatal and early postnatal circumstances may alter a person's vulnerability to chronic diseases later in life. Epigenetic modulation of gene expression has been proposed as one of the processes through which early life environment impacts future illness risk. It is possible that our understanding of the underlying mechanisms may lead us to design new intervention strategies that can lessen the burden of sickness in later life.
Un diagnostic clinique parfois difficile : ulcères de jambe et cancer
Authors: Anne JANIN
Published: April 2022

Le développement d’un cancer sur un ulcère chroniquede jambe est une éventualité connue, mais qui peut êtredifficile à diagnostiquer.Nous centrons cette revue moins sur les cancers ulcérésque sur les cancers se développant sur des ulcères anciens.Les carcinomes spinocellulaires sont les plus fréquentset une biopsie doit être réalisée au moindre doute pourassurer une exérèse chirurgicale la plus complète possible.Si l’on soupçonne un mélanome, une exérèse complètede la lésion suspecte doit être effectuée, et non un prélèvement biopsique.L’analyse microscopique de la lésion permet de confirmerle diagnostic de cancer
Pengaruh Penilaian Emosi Diri terhadap Motivasi Kerja Dukungan Sosial sebagai Variabel Intervening
Authors: Ramaida  , Fahmi Oemar
Published: April 2022

Penelitian ini dilaksanakan pada UPT Puskesmas Tembilahan Kota dengan tujuan untuk mengetahui efek mediasi dukungan sosial pada pengaruh penilaian emosi diri terhadap motivasi. Populasi penelitian yang dilakukan peneliti adalah pegawai negeri sipil dan non pegawai negeri sipil dilingkungan UPT Puskesmas Tembilahan Kota. Jumlah populasi dalam penelitian ini sekaligus dijadikan sampel sebanyak 93 orang. Analisa data penelitian ini menggunakan statistik deskriptif dan analisis verifikatif, sebagai alat analisis digunakan Struktural Equational Model yang diproses dengan software SmartPLS2. Hasil analisis membuktikan bahwa pada UPT Puskesmas Tembilahan Kota terdapat pengaruh yang signifikan penilaian emosi diri terhadap motivasi, terdapat pengaruh yang tidak signifikan dukungan sosial terhadap motivasi, terdapat pengaruh yang signifikan penilaian emosi diri terhadap dukungan sosial, dukungan sosial tidak berperan sebagai variabel mediasi pada Pengaruh Penilaian Emosi diri terhadap motivasi.
Convergence analysis of a local stationarity scheme for rate-independent systems
Authors: Sievers Michael
Published: April 2022

This paper is concerned with an approximation scheme for rate-independent systems governed by a non-smooth dissipation and a possibly non-convex energy functional. The scheme is based on the local minimization scheme introduced in Efendiev and Mielke [J. Convex Anal. 13 (2006) 151–167], but relies on local stationarity of the underlying minimization problem. Under the assumption of Mosco-convergence for the dissipation functional, we show that accumulation points exist and are so-called parametrized BV-solutions of the rate-independent system. In particular, this guarantees the existence of parametrized BV-solutions for a rather general setting. Afterwards, we apply the scheme to a model for the evolution of damage.
Real-World Experience with CDK4/6 Inhibitors for Metastatic HR+/HER2− Breast Cancer at a Single Cancer Center
Authors: Knudsen Erik S , Schultz Emily , Hamilton Deanna , Attwood Kris , Edge Stephen , O’Connor Tracey , Levine Ellis , Witkiewicz Agnieszka K
Published: April 2022

Background

A study was initiated at Roswell Park Comprehensive Cancer Center to capture the real-world experience related to the use of CDK4/6 inhibitors (Ciclibs) for the treatment of metastatic hormone receptor-positive and HER2-negative breast cancer (HR+/HER2-).

Patients and Methods

A total of 222 patients were evaluated who received CDK4/6 inhibitors in the period from 2015 to 2021. Detailed clinical and demographic information was obtained on each patient and used to define clinical and demographic features associated with progression-free survival on CDK4/6 inhibitor-based therapies.

Results

In this real-world analysis, the majority of patients received palbociclib as the CDK4/6 inhibitor with letrozole or fulvestrant as the predominant endocrine therapies. The median progression-free survival (PFS) in the letrozole (27.6 months) and fulvestrant (17.2 months) groups were comparable to that observed in clinical trials. As expected, age at start of the treatment and menopausal status influenced endocrine therapy utilization but were not associated with PFS. Patients with recurrent disease had shorter PFS (P = .0024) than those presenting with de novo metastasis. The presence of visceral metastasis trended toward shorter PFS (P = .051). Similarly, prior endocrine therapy (P = .003) or chemotherapy (P = .036) was associated with shorter PFS. Body mass index was not associated with PFS or with dose interruption and/or modification. While the number of minorities in this analysis is limited (n = 26), these patients as a group had statistically shorter PFS on treatment (P = .002).

Conclusions

The real-world progression-free survival with CDK4/6 inhibitors mimics that observed in the clinical trial. A number of clinical and demographic features were associated with PFS on CDK4/6 inhibitor-based therapy. Further studies are ongoing to validate these findings incorporating additional cancer centers.
Silk fibroin‐based films in food packaging applications: A review
Authors: Low Jia Tee , Yusoff Noor Izyan Syazana Mohd , Othman Norhayani , Wong Tuck‐Whye , Wahit Mat Uzir
Published: April 2022

Plastic pollution is a significant concern nowadays due to wastes generated from non‐biodegradable and non‐renewable synthetic materials. In particular, most plastic food packaging material ends up in landfills, creating mass wastes that clog the drainage system and pollute the ocean. Thus, studies on various biopolymers have been promoted to replace synthetic polymers in food packaging and consequently, the high number of research in biopolymers food packaging, especially in the characterization, properties and also the development of the biopolymer. For biopolymer‐based food packaging, silk fibroin (SF) has been highlighted because of its biodegradability and low water vapor permeability properties. This review focuses on the different properties of SF films prepared through solution casting and electrospinning for food packaging. Discussions encompassed chemical properties, mechanical properties, permeability, and biodegradability. This review also discussed the studies that used SF as the biomaterial for food packaging.
Camel milk composition by breed, season, publication year, and country: A global systematic review, meta‐analysis, and meta‐regression
Authors: Alhaj Omar A. , Altooq Noor J. , Alenezi Ahmad F. , Janahi Abdulrahman I. , Janahi Mohamed I. , Humood Ali M. , AlRasheed Maha M. , Bragazzi Nicola L. , Jahrami Haitham A. , Faye Bernard
Published: April 2022

Camel milk consists of an essential macro/micronutrient for human nutrition in the arid and urban regions. This review study aimed to use meta‐analysis statistical techniques for assessment and correction of publication bias, exploration of heterogeneity between studies, and detailed assessment of the effect of a comprehensive set of moderators including breed, season, country, year of publication, and the interaction between composition elements. This could provide a single synthesis of the camel milk composition to warrant strong generalizability of results, examine variability between available studies, and analyze differences in camel milk composition among different exposures. Such a finding will aid future researchers and health professionals in acquiring a more precise understanding of camel milk composition and drawing more clinical implications. Six searching databases and bibliographic were used including PubMed/MEDLINE, ScienceDirect, Springer, EBSCOhost, Scopus, and Web of Science from January 1980 to December 2021. The DerSimonian–Laird estimator was used to create the current random‐effects meta‐analysis. This systematic review and meta‐analysis included a total of 7298 camel milk samples from 23 countries. This review comprises 79 studies published in the English language on or after 1980, including a subgroup of 117 analyses consisting of seasons, sub‐breeds, and countries. The contents of macro/micronutrients in camel milk were identified as follows: protein, 3.17%; fat, 3.47%; lactose, 4.28%; ash, 0.78%; and total solids, 11.31%; calcium, 112.93 mg/100 g; iron, 0.45 mg/100 g; potassium, 116.13 mg/100 g; magnesium, 9.65 mg/100 g; sodium, 53.10 mg/100 g; zinc, 1.68 mg/100 g; vitamin C, 5.38 mg/100 g; vitamin A, 0.36 mg/100 g; vitamin B1,0.05 mg/100 g; vitamin B2, 0.13 mg/100 g; vitamin B3, 0.51 mg/100 g; vitamin B6, 0.09 mg/100 g; and vitamin B12, 0.0039 mg/100 g. Our meta‐regression analysis found that fat and total solids were statistically significant moderators of protein; moreover, total solids content is a statistically significant moderator of fat. Discrepancies observed in camel milk profiles are dependent upon several factors, including number of included studies, number of samples, different analytical techniques, feeding patterns, camel's breeds, geographical locations, and seasonal variations.
The European Sleep Research Society – past, present and future
Authors: Deboer Tom , Arnardóttir Erna Sif , Landolt Hans‐Peter , Luppi Pierre Hervé , McNicholas Walter T. , Pevernagie Dirk , Plazzi Giuseppe ,   The board of the European Sleep Research Society (ESRS)
Published: April 2022

It is 50 years ago, in 1972, that the founding conference of the European Sleep Research Society (ESRS) was organised in Basel. Since then the Society has had 13 presidents and a multitude of board members and has organised, among other things, another 24 congresses. At this 50th anniversary, as the 26th ESRS congress is approaching, we have summarised the history of the ESRS. In this review, we provide a background to show why the foundation of a European society was a logical step, and show how, in the course of the past 50 years, the Society changed and grew. We give special attention to some developments that occurred over the years and discuss where the ESRS stands now, and how we foresee its future.
Catheter ablation for persistent atrial fibrillation with left ventricular systolic dysfunction: Who is the best candidate?
Authors: Yu Lu , Jiang Ruhong , Sun Yaxun , Ye Yang , Zhang Pei , Liu Qiang , Sheng Xia , Zhang Zuwen , Chen Shiquan , Fu Guosheng , Jiang Chenyang
Published: April 2022

Background

Tachycardia‐induced cardiomyopathy is poorly recognized pre‐ablation. It remains unclear of better patient selection and timing for catheter ablation in persistent atrial fibrillation (PerAF) with heart failure (HF).

Methods

Consecutive patients with PerAF and left ventricular ejection fraction (LVEF) <50% referred for AF ablation were retrospectively included. The impact of LV size, heart rate (HR), and LVEF pre‐ablation were analyzed for assessing LV systolic function recovery, defined as LVEF increase of ≥20% or to a value ≥55% after ablation.

Results

A total of 120 patients (2017–2020) were included. After 19 ±14 months post ablation, LVEF improvement was similar in patients with normal or dilated LV (18.3 ± 9.4% vs. 16.1 ± 10.8%, P = .25), rapid or controlled HR (19.5 ± 10% vs. 16.1 ± 10%, P = .09), but higher in HFrEF (HF with reduced EF) than HFmrEF (HF with midrange EF) (21.6 ± 10.3% vs. 14.9 ± 9.3%, P < .01). There was more LV systolic function recovery in those with normal to moderate LV dilation (80%, odds ratio [OR] 15.22, P < .01), HR ≥80 bpm (79%, OR 5.38, P < .01) and HFmrEF (80%, OR 4.03, P < .01). The overall AF freedom was similar between normal and dilated LV (59% vs. 62%, P = .95), rapid and controlled HR (67% vs. 56%, P = .18), and HFmrEF and HFrEF (65% vs. 50%, P = .19).

Conclusion

Catheter ablation is effective independent of LV dilation, rate control or HFrEF. Patients with normal to moderate LV dilation, resting HR ≥80 bpm and HFmrEF may be candidates for early PerAF ablation to achieve LVEF normalization.
Challenges and Imperatives of Deep Learning Approaches for Detection of Melanoma: A Review
Authors: Gayatri Erapaneni , Aarthy S. L.
Published: April 2022

Recently, melanoma became one of the deadliest forms of skin cancer due to ultraviolet rays. The diagnosis of melanoma is very crucial if it is not identified in the early stages and later on, in the advanced stages, it affects the other organs of the body, too. Earlier identification of melanoma plays a major role in the survival chances of a human. The manual detection of tumor thickness is a very difficult task so dermoscopy is used to measure the thickness of the tumor which is a non-invasive method. Computer-aided diagnosis is one of the greatest evolutions in the medical sector, this system helps the doctors for the automated diagnosis of the disease because it improves accurate disease detection. In the world of digital images, some phases are required to remove the artifacts for achieving the best accurate diagnosis results such as the acquisition of an image, pre-processing, segmentation, feature selection, extraction and finally classification phase. This paper mainly focuses on the various deep learning techniques like convolutional neural networks, recurrent neural networks, You Only Look Once for the purpose of classification and prediction of the melanoma and is also focuses on the other variant of melanomas, i.e. ocular melanoma and mucosal melanoma because it is not a matter where the melanoma starts in the body.
Generic Gelfand-Tsetlin representations of Uqtw(𝔰𝔬3) and Uqtw(𝔰𝔬4)
Authors: Disch Jordan
Published: April 2022

We construct generic Gelfand-Tsetlin representations of the [Formula: see text]quantum groups [Formula: see text] and [Formula: see text]. These representations are infinite-dimensional analogs to the finite-dimensional irreducible representations provided by Gavrilik and Klimyk in [[Formula: see text]-deformed orthogonal and pseudo-orthogonal algebras and their representations, Lett. Math. Phys. 21 (1991) 215–220]. They are quantum analogs of generic Gelfand-Tsetlin representations constructed by Mazorchuk in [On Gelfand-Zetlin modules over orthogonal Lie algebras, Algebra Colloq. 8 (2001) 345–360]. We give sufficient conditions for irreducibility and provide an upper bound for the length with the help of Casimir elements found by Molev, Ragoucy and Sorba.
Site Selection of Precast Concrete Component Factory Based on PCA and GIS
Authors: Wang Shuqiang , Ruan Yuke , Hu Wanwei
Published: April 2022

In China, with the expansion of the prefabricated construction market, the demand for precast concrete (PC) components is increasing and the construction of production plants to meet this need is expanding. To address the problem of siting PC component plants in China's construction industry, a combination of qualitative and quantitative analysis using principal component analysis (PCA) and geographic information system (GIS) is proposed for their siting. Taking the site selection process of a PC component plant in Wuhan, Hubei Province, China as an example, the diamond model is combined with six dimensions of environmental factors, requirements, regional competition, related and supporting industries, technological innovation and policies and regulations to construct an indicator system for PC component plant site selection. In the preliminary selection stage, PCA was applied to analyze the site selection indexes to obtain the overall score and ranking of each district for the selection of PC component plants in Wuhan, and it was concluded that three districts, namely, Xinzhou, Hannan, and Huangpi, were more suitable for the construction of component plants. In the precise selection stage, based on the availability of data, Hannan was selected among the three areas suitable for site selection for GIS analysis, using the visual‐spatial analysis function of GIS to quantify the four geographical information indicators of environmental factors, and the results showed that Area C in Hannan was the most suitable area. The results show that the method has high accuracy and good applicability.
Creative Self-efficacy, Political Decision-making, and Offline and Online Political Participation
Authors: Kushin Matthew J. , Dalisay Francis , Kim Jinhee , Forbes Amy , David Clarissa C. , Somera Lilnabeth P.
Published: April 2022

Creativity plays an important role in politics in both online and offline spaces. Creative forms of political participation have long been tools of disenfranchised groups in their efforts to influence the government. Further, the rise of online creative participatory cultures has afforded new opportunities for civic and political involvement. Creative forms of participatory politics have the potential to facilitate exposure to ideas, foster dialogues, influence agendas and serve as ways to back talk authority. While many avenues for political involvement are creative, the role creativity may play in citizens’ political engagement is not well understood. This study examined the role of creative self-efficacy in political engagement and civic outcomes. Creative self-efficacy represents a belief in one’s ability to produce creative outcomes. A survey of participants living in Australia, South Korea, the Philippines and the USA (USA, Hawaii and Guam) ( N = 807) was conducted. Findings suggest that creative self-efficacy was positively associated with political efficacy and scepticism and not associated with apathy. Creative self-efficacy was indirectly associated with offline and online political participation through political efficacy. The implications of these findings are discussed in context of the role creative self-efficacy may play in impacting political outcomes.
[RETRACTED] Keto Light Plus Reviews - How Does It Works? v1
Authors: not provided ketolightplusreviews
Published: April 2022

[RETRACTED]

Keto Light Plus Reviews - How Does It Works?
Quality of wavefront reversal for four-wave interaction in a multimode waveguide with thermal nonlinearity
Authors:   Samara National Research University, Ivakhnik V.V. , Kapizov D.R. ,   Samara National Research University, Nikonov V.I. ,   Samara National Research University
Published: April 2022

For a four-wave radiation converter in a two-dimensional multimode waveguide with thermal nonlinearity at a low reflection coefficient, we analyze the influence of the spatial structure of pump waves on the quality of wavefront reversal. It is shown that the half-width of modulus of the point spread function of a four-wave radiation converter decreases with decreasing radius of Gaussian pump waves on the waveguide edges, leading to an improvement in the quality of wavefront reversal. For a four-wave radiation converter in a two-dimensional waveguide with infinitely conducting surfaces, we show the presence of "generation" points, near which a sharp increase in the object wave amplitude is observed, with its form completely determined by one of the waveguide modes.
Determination of the orbital angular momentum state of a radio wave beam based on quantitative characteristics of a radio communication system
Authors: Anufriyev E.G.
Published: April 2022

Nowadays, due to the lack of available radio frequency spectrum, there is a need for the development of technologies that would make it possible to use this spectrum more efficiently. One such technology involves the use of radio waves with orbital angular momentum (OAM). This paper proposes a new quantitative method for determining the number of single states of a beam carrying OAM based on an analysis of the S21 system parameters. This allows the receiver to be tuned to receive beams with a specific OAM state. The radio waves carrying OAM have a frequency of 80 GHz. In this work, a pyramidal horn was used as a transmitting antenna, with a spiral phase plate used to twist the emitted radio wave. An array of receiving antennas was in the form of dipoles. Limitations of this method were investigated. This work is a computer experiment.
Detection of fungal and bacterial contamination of hazelnut and determination of aflatoxin B by HPLC method in Isfahan, Iran
Authors: Saffari Elham , Madani Mahboobe , Karbasizade Vajihe , Shakib Pegah
Published: April 2022

Background and Purpose: Due to the fact that fungal species such as Aspergillus flavus and Aspergillus parasiticus produce carcinogenic and mutagenic aflatoxins and have the potential to produce fungal secondary metabolites, fungal contamination should be avoided. This study was conducted using the HPLC method and was aimed at examining the fungal contamination of Isfahan hazelnuts in order to identify the presence of Aflatoxins.
Materials and Methods: One hundred samples of hazelnuts were randomly collected from supermarkets in Isfahan. The samples were then cultured on Sabouraud dextrose agar (SDA) media and analyzed to determine fungal contaminations. The aflatoxin analysis was carried out using the HPLC method.
Results: It was discovered that nine genera of fungi, namely Aspergillus, Penicillium , Rhizopus, Ulocladium, Alternaria, Drechselera, Trichothecium, Scopulariopsis, and Mucor were identified in 78% of the samples. Samples contaminated with Aspergillus flavus (22 samples) were studied to determine the presence of aflatoxin. The results showed that 16 (72.72%) of the samples were contaminated with AFB1, AFB2 and AFG2 and the mean concentrations were 0.926, 0.563 and 0.155ng/g, respectively.
Conclusions: Some parameters that affect mycotoxin production are temperature, food substrate, strain of the mold and other environmental factors. Due to the toxigenic quality of some of these fungi and their hazard to human health, it is crucial that fungal contamination and aflatoxin identification tests are carried out before certain products are made available to the mass market.
Incidence and Prognostic Impact of WT-1 Gene Exon7 and 9 Mutations in Acute Promyelocytic Leukemia
Authors: Nejatifar Fatemeh , Rostami Shahrbano , Chahardouli Barham , Kasaeian Amir , Vaezi Mohammad , Kamranzadeh Hossein , Mousavi Seied Asadollah , Farbod Abolfazl , Alimoghaddam Kamran , Ghavamzadeh Ardeshir
Published: April 2022

Background: Wilms’ tumor gene 1 (WT1) gene mutation has been reported to be a prognostic factor in normal-cytogenetic acute myeloid leukemia (AML) patients. Higher rates of mutation in the WT1 gene have been reported in several tumors including normal-cytogenetic AML patients. Data regarding WT1 mutations in acute promyelocytic leukemia (APL) is very scarce. In this study, we evaluated the incidence and impact of WT1 mutation on the outcome of APL patients.
Materials and Methods: A total of 92 patients diagnosed with APL were studied in three distinct groups: early mortality, relapsed, and persistent complete remission. Genomic DNA of bone marrow samples of patients was analyzed. For quantification of expression levels of the WT1 gene, real-time quantitative PCR (rqPCR) was performed by a real-time PCR system. WT1 mutation and its impact on prognosis were considered the primary endpoint of the study. Statistical analysis was performed with STATA.
Results: WT1 mutation frequency was 6.25% in the early mortality group (1/16 patients), 13.16% in the relapse group (5/38 patients), and 7.89% in the persistent complete remission group (3/38 patients). 8 mutations were in exon 7 and one mutation in exon 9. WT1 mutation in the relapse group was associated with a trend toward worse disease-free survival (DFS) while overall survival (OS) was not affected by WT1 mutation in univariate analysis. Patients with no mutations in WT1 and FLT3/ITD had better overall survival and disease-free survival compared to patients with mutations in the WT1 gene or FLT3/ITD in the relapse group.
Conclusion: The frequency of WT1 gene mutations does not differ significantly between patients with early mortality, relapse, and persistent complete remission. The presence of WT1 mutation is associated with higher relapse and lower survival rates in relapse group patients.
The Diagnostic Value of Ultrasound-Guided Cervical Core Needle Biopsy in Diagnosis of Lymphoma in Suspected Patients
Authors: Kazemi Mohammad Ali , Yazdani Farzad , Sharifian Hashem , Aghazadeh Keyvan , Moradi Behnaz , Behravan Hengameh , Mikelani Mohsen
Published: April 2022

Background: Core needle biopsy (CNB) guided by imaging modalities seems to be an acceptable modality for diagnosis of lymphoma due to its safety, good applicability, availability as well as diagnostic accuracy, however; Studies have not reached a consensus on its diagnostic accuracy and factors affecting its performance. The present study aimed to assess the value of ultrasound-guided cervical CNB in the diagnosis of lymphoma in suspected patients.
Materials and Methods: This cross-sectional study was performed on 46 consecutive patients (20 to 82 years) with cervical mass or lymphadenopathy suspected of lymphoma and were candidates for diagnostic evaluation. Ultrasound-guided core needle biopsies (UGCNB) were done by a single radiologist under guided ultrasonography. The diagnostic value of UGCNB in the diagnosis and determination of specific lymphoma subtypes was assessed.
Results: Using UGCNB led to the diagnosis of lymphoma in 34.8% and non-lymphoma lesions in 43.5%, while the diagnosis remained unclear in other 21.7% with a total UGCNB-based identification rate of 78.3%. No patient with lymphoma was missed. All patients were followed up over a 6-month period. In none of the cases, clinical diagnosis and treatment response were found contrary to the initial pathologic diagnosis. No significant complication such as hematoma or infection was reported.
Conclusion: UGCNB has a high diagnostic value for determining the nature of the cervical lesions suspected of lymphoma.
Clinical and Pathological Features of Double-Hit and Triple-Hit High-Grade B-Cell Lymphomas: A Retrospective Study from Three Portuguese Tertiary Centers
Authors: Almeida Rui , Abrantes Carlos , Gigliano Davide , Oliveira Rui Caetano , Teixeira Paulo , Viegas Marta , Rodrigues Ângelo , Julião Maria José
Published: April 2022

Background: High-grade B-cell lymphoma (HGBL) with rearrangements of MYC and BCL2 and/or BCL6, called double and triple-hit lymphomas (DTH-HGBL), are lymphoid malignancies with inferior outcomes when treated with standard chemotherapy. The identification of DTH-HGBL cases is challenging, considering their variable clinical, morphologic, and immunohistochemical features.
Materials and Methods: Retrospective revision of medical data of patients diagnosed with DTH-HGBL confirmed by FISH, between January 2010 and January 2020, in three Tertiary Portuguese Hospitals (Coimbra Hospital and University Center, Portuguese Oncology Institute – Coimbra and Portuguese Oncology Institute – Porto). Pathological features, morphology, and immunohistochemical profile were evaluated by at least two experienced pathologists in hematopoietic and lymphoid neoplasms.
Results: The cohort included 24 patients: 33.3% triple-hit, 58.3%, MYC/BCL2 double-hit and 8.3% MYC/BCL6 double-hit. There was no gender predominance, with a median age of 62.5±14.3y, 33.3% were diagnosed as nodal disease, and 66.7% as extranodal. Morphologic features of  DLBCL were present in 50% of cases, morphological features of both DLBCL and Burkitt lymphoma (DLBCL/BL) in 45.8% and 4.2% of blastoid morphology. Immunohistochemical evaluation, regarding the Hans algorithm, revealed a Germinal center (GC)/GC-like subtype in 83.3% of cases and a non-GC/non-GC-like subtype in 16.7%.  MYC was positive in 42.9% and the median proliferative index was 80±12.4%.
Conclusion: DTH-HGBL has a very broad range of features. We consider that a cost-effective approach would be to perform cytogenetic analysis in DLBCL and DLBCL/BL cases with GC/GC-like subtype. MYC and BCL2 immunohistochemistry can be useful to identify patients who may benefit from more aggressive therapies, but not as tools for case selection for FISH.
Assessment the Effect of Human Umbilical Cord Wharton's Jelly Stem Cells on the Expression of Homing Genes; CXCR4 and VLA-4 in Cell Line of Breast Cancer
Authors: Vahdanikia Vida , Maleki Masoud , Irani Fam Roya Asl , Abdi Adel
Published: April 2022

Background: Breast cancer is the most common cancer in women.  The prevalence of breast cancer in Western women is one in eight.  Although the prevalence of breast cancer in Iran is lower than in Western countries (one in every 10-12 women), the incidence of breast cancer in it is 5-10 years earlier than in Western countries. Breast cancer is the second leading cause of cancer death among women after lung cancer. Therefore, finding new therapeutic methods could potentially help to reduce breast cancer mortality and increase the survival rate. Wharton jelly stem cells with mesenchymal morphology play an important role in inhibiting the progression of ovarian, osteosarcoma, and breast cancer by inducing apoptosis and reducing metastasis. Several environmental and genetic factors are involved in the occurrence of breast cancer. CXCR4 and VLA-4 genes are important genetic factors in breast cancer that play a role in cell survival, migration, proliferation, and metastasis of several types of cancer, especially breast cancer. Therefore, inhibition of these two genes by Wharton's Jelly Stem Cells could be a novel and effective therapeutic target in breast cancer.  The aim of this study was to investigate the effect of Wharton jelly stem cells secretion on the expression of CXCR4 and VLA-4 genes in cancer cells.
Materials and Methods: These cells were exposed to Wharton's Jelly Stem Cells after culturing breast cancer cells. RNA was extracted from treated cells. The expression of CXCR4 and VLA-4 genes was evaluated by real-time PCR.
Results: The results of the MTT and Scratching tests showed a significant difference compared to the control group. Also, the results of Real-time PCR showed a significant decrease in the expression of CXCR4 and VLA-4 genes compared to the control group.
Conclusion: The results of this study showed that different concentrations of Wharton Jelly Stem Cells reduce cancer cell growth and expression of CXCR4 and VLA-4 homing genes in MDA-MB-231 breast cancer cells. Therefore, Wharton Jelly Stem Cells can be considered as an effective treatment for breast cancer.
Opinions of cardiologists on class II recommendations in current European Society of Cardiology 2018-2020 guidelines: YELLOW BOX
Authors: KIŞ Mehmet , GÜZEL Tuncay , EKİCİ Berkay , ZOGHİ Mehdi
Published: April 2022

Objectives: We planned our survey study to evaluate the opinion of cardiologists about the class II recommendations on levels of evidence in the current European Society of Cardiology Guidelines (ESC). Our aim is to determine which diagnosis or treatment option most prefer by cardiologist when guidelines do not make clear recommendations.
Methods: The survey was conducted on September 2020 with the participation of cardiologists (n = 102). Our survey covers ESC's guidelines published in 2018-2020 on diagnosis and treatment strategies in coronary artery disease, diabetes, heart valve disease, arrhythmia, dyslipidemia and heart failure. Our survey consisting of 40 questions was shared with the cardiologists via e-mail.
Results: Participants answered all of the survey questions. The majority of the participants (79.41%) did not consider the addition of a second long-term antithrombotic medication in addition to aspirin for secondary prevention in diabetes mellitus (DM) and coronary artery disease (CAD) patients who are not at high risk of bleeding. The lowest low density lipoprotein (LDL) value achieved by the participant physicians with treatment in their practices was < 40 mg/dl in 32 (31.37%) participants . One of the striking results of the survey was that 51.96% of the participants stated that it was not possible to measure the lipoprotein a (Lp(a)) level in the center where they were carrying out their practices, and 34.31% did not consider the Lp(a) level in the treatment of dyslipidemia in terms of directing the treatment. As for patients with asymptomatic Wolff-Parkinson-White (WPW) syndrome, 58.82% of the participants considered catheter ablation therapy.
Conclusions: Although there were different opinions on some recommendations, the participants were mostly in agreement. We think that these survey results, which were mostly based on expert opinions, may contribute to the guidelines to be published in the future with the increase of survey studies on these issues.
Black Metal Istiqomah Dakwah "Hitam" di Media Sosial
Authors: Apriko M Syendi
Published: April 2022

Media supporting da'wah is not only limited to the pulpit of the mosque but has come in contact with modern communication technology, especially the use of the internet. This ease has an impact on the number of users from social media who actively share da'wah content so that it becomes viral. Another da'wah phenomenon that attracted the attention of researchers was the 'black' da'wah uploaded on social media by the Black Metal Istiqomah account through both social media Facebook and Instagram. On Instagram, this account has the name of the shadow Al-Varokah Nur Vahalla with followers of more than 16 thousand and the number of posts as many as 179. Researchers discuss further uploaded by this account and view it from the point of view of visual communication using theories that have been tested and use qualitative methods. There are several visual techniques used in Black Metal Istiqomah including; shading techniques, Dussel techniques, pointillary techniques, collage techniques and dry techniques. Work in the form of; comic stip, prayer illustration, typography made with the shape and style of Black metal music. In conclusion, the style of Black metal that is used only as an artistic form of attraction in order to create different nuances in conveying da'wah messages to young people has nothing to do with the heretical and negative schools which have been attached to Black metal music.