bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of host biomarkers from dried blood spots for monitoring treatment response in extrapulmonary tuberculosis
Authors: Khalid Shizza , Ambreen Atiqa , Khaliq Aasia , Ullah Hafeez , Mustafa Manal , Mustafa Tehmina
Published: January 2023

There is a lack of objective tools for monitoring treatment response in extrapulmonary tuberculosis (EPTB). This study aimed to explore the utility of inflammatory biomarkers from the dry blood spots (DBS) as a tool for monitoring treatment response in EPTB. In a prospective cohort study, 40 inflammatory biomarkers were investigated in DBS samples from 105 EPTB cases using a Luminex platform. The samples were taken before, and, at the end of the 2nd and 6th months of treatment. A total of 11 inflammatory host biomarkers changed significantly with treatment in all EPTB patients. CXCL9/MIG, CCL20, CCL23, CXCL10/IP-10, CXCL1, CXCL2, and CXCL8 significantly declined in our cohort of EPTB (48 TB pleuritis and 57 TB lymphadenitis) patients at both time points. A biosignature consisting of MIG, CCL23, and CXCL2, corresponded with the treatment response in 81% of patients in the 2nd month and 79% of patients at the end of treatment. MIG, CCL23, IP-10, and CXCL2 changed significantly with treatment in all patients including those showing partial clinical response at the 2nd month of treatment. The changes in the levels of inflammatory biomarkers in the DBS correspond with the treatment success and can be developed as a routine test in low-resource settings.
Salivary peptidome analysis and protease prediction during orthodontic treatment with fixed appliances
Authors: Wazwaz Fidaa , Saloom Hayder , Houghton Jack W. , Cobourne Martyn T. , Carpenter Guy H.
Published: January 2023

Orthodontic tooth movement (OTM) occurs through proteolytic remodelling within the periodontium following the application of external force to the tooth. This study describes the first characterization of the salivary peptidome and protease profile during the alignment stage of fixed appliance orthodontic treatment. Unstimulated whole mouth saliva from 16 orthodontic patients (10 males, 6 females, mean (SD) age 15.2 (1.6) years) was collected prior to fixed appliance placement (T1), 1-h (T2), 1-week (T3) following fixed appliance placement and on completion of mandibular arch alignment (T4). Salivary peptides were extracted using filtration followed by mass spectrometry to identify amino acid sequences. Protease prediction was carried out in silico using Proteasix and validated with gelatin zymography and enzyme-linked immunosorbent assay. A total of 2852 naturally-occurring peptides were detected, originating from 436 different proteins. Both collagen and statherin-derived peptide levels were increased at T2. Proteasix predicted 73 proteases potentially involved in generating these peptides, including metalloproteinases, calpains and cathepsins. Changes in predicted activity of proteases over time were also observed, with most metalloproteinases showing increased predicted activity at T2–T3. Increased gelatinolytic activity and MMP8/MMP9 levels were detected at T3. Collectively, multiple protein targets and changes in protease-predicted activity during OTM have been identified.
Vascular impulse technology versus elevation for reducing the swelling of upper and lower extremity joint fractures
Authors: El Barbari Jan S. , Schnetzke Marc , Bergmann Moritz B. , Baumann Lukas , Vetter Sven Y. , Swartman Benedict , Grützner Paul A. , Franke Jochen
Published: January 2023

Soft-tissue conditioning due to posttraumatic oedema after complicated joint fractures is a central therapeutic aspect both pre- and postoperatively. On average, 6–10 days pass until the patient is suitable for surgery. This study compares the decongestant effect of vascular impulse technology (VIT) with that of conventional elevation. In this monocentric RCT, 68 patients with joint fractures of the upper (n = 36) and lower (n = 32) extremity were included and randomized after consent in a 1:1 ratio. Variables were evaluated for all fractures together and additionally subdivided into upper or lower extremity for better clinical comparability. Primary endpoint was the time in days from hospital admission to operability. Secondary endpoints were total length of stay, oedema reduction, pain intensity, complications, and revisions. The time from admission until operability was reduced by 1.4 (95% CI − 0.4; 3.1) days in the mITT analysis (p = 0.120) and was statistically significant with 1.7 (95% CI 0.1; 3.3) days in the as-treated sensitivity analysis (pAT = 0.038). Significantly less pain and a faster oedema reduction were found in the intervention group. Due to rare occurrences, nothing can be concluded regarding complications and revisions. Administration of VIT therapy did not lead to a significant reduction in time until operability in the whole population but was superior to elevation for soft-tissue conditioning and pain reduction. However, there was a significant reduction by 2.5 days (95% CI 0.7; 4.3) in the subgroup of lower extremity fractures. VIT therapy therefore seems to be a helpful tool in the treatment of posttraumatic oedema after complex joint fractures of the lower and upper extremity, especially in tibial head and lower leg fractures.
Complex multiple introductions drive fall armyworm invasions into Asia and Australia
Authors: Rane Rahul , Walsh Thomas K. , Lenancker Pauline , Gock Andrew , Dao Thi Hang , Nguyen Van Liem , Khin Thein Nyunt , Amalin Divina , Chittarath Khonesavanh , Faheem Muhammad , Annamalai Sivapragasam , Thanarajoo Sathis Sri , Trisyono Y. Andi , Khay Sathya , Kim Juil , Kuniata Lastus , Powell Kevin , Kalyebi Andrew , Otim Michael H. , Nam Kiwoong , d’Alençon Emmanuelle , Gordon Karl H. J. , Tay Wee Tek
Published: January 2023

The fall armyworm (FAW)Spodoptera frugiperdais thought to have undergone a rapid ‘west-to-east’ spread since 2016 when it was first identified in western Africa. Between 2018 and 2020, it was recorded from South Asia (SA), Southeast Asia (SEA), East Asia (EA), and Pacific/Australia (PA). Population genomic analyses enabled the understanding of pathways, population sources, and gene flow in this notorious agricultural pest species. Using neutral single nucleotide polymorphic (SNP) DNA markers, we detected genome introgression that suggested most populations in this study were overwhelmingly C- and R-strain hybrids (n = 252/262). SNP and mitochondrial DNA markers identified multiple introductions that were most parsimoniously explained by anthropogenic-assisted spread, i.e., associated with international trade of live/fresh plants and plant products, and involved ‘bridgehead populations’ in countries to enable successful pest establishment in neighbouring countries. Distinct population genomic signatures between Myanmar and China do not support the ‘African origin spread’ nor the ‘Myanmar source population to China’ hypotheses. Significant genetic differentiation between populations from different Australian states supported multiple pathways involving distinct SEA populations. Our study identified Asia as a biosecurity hotspot and a FAW genetic melting pot, and demonstrated the use of genome analysis to disentangle preventable human-assisted pest introductions from unpreventable natural pest spread.
Altered gut microbiota in individuals with episodic and chronic migraine
Authors: Yong Dongeun , Lee Hakbae , Min Hyung-Gyu , Kim Kyungnam , Oh Hyun-Seok , Chu Min Kyung
Published: January 2023

Emerging evidence reveals a close association between gut microbiota and human neurological disorders. The present study aimed to assess whether the composition of gut microbiota in participants with episodic migraine (EM) and chronic migraine (CM) was altered in comparison to that of the controls. This study was a cross-sectional, case–control study. The gut microbiota were evaluated by the partial, targeted sequencing of the 16S rRNA V3–V4 region. This study enrolled 42 and 45 participants with EM and CM, respectively, and 43 controls. Alpha and beta diversities revealed no significant difference among the three groups; however, the microbiota composition at the class, order, family, and genus levels differed significantly between EM and the control, CM and the control, and the EM and CM groups. Moreover, higher composition of PAC000195_g was significantly associated with a lower headache frequency among the five genera that exhibited significantly different microbiota composition in EM and CM. Agathobacter revealed a significant negative association with severe headache intensity. The findings of the present study provide evidence of altered gut microbiota in EM and CM. These findings will help in understanding the course and treatment of migraine.
Linagliptin treatment is associated with altered cobalamin (VitB12) homeostasis in mice and humans
Authors: Tammen Harald , Kömhoff Martin , Delić Denis , Lund Søren S. , Hocher Berthold , Frankenreiter Sandra , Hess Rüdiger , von Eynatten Maximilian , Mark Michael , Klein Thomas
Published: January 2023

Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used for the treatment of type 2 diabetes, with additional beneficial effects for the kidney. Treatment of mice with linagliptin revealed increased storage of cobalamin (Cbl, Vitamin B12) in organs if a standard Cbl diet (30 µg Cbl/kg chow) is given. In order to translate these findings to humans, we determined methylmalonic acid (MMA), a surrogate marker of functional Cbl homeostasis, in human plasma and urine samples (n = 1092) from baseline and end of trial (6 months after baseline) of the previously completed MARLINA-T2D clinical trial. We found that individuals with medium Cbl levels (MMA between 50 and 270 nmol/L for plasma, 0.4 and 3.5 µmol/mmol creatinine for urine, at baseline and end of trial) exhibited higher MMA values at the end of study in placebo compared with linagliptin. Linagliptin might inhibit the N-terminal degradation of the transcobalamin receptor CD320, which is necessary for uptake of Cbl into endothelial cells. Because we demonstrate that linagliptin led to increased organ levels of Cbl in mice, sustained constant medium MMA levels in humans, and inhibited CD320 processing by DPP-4 in-vitro, we speculate that linagliptin promotes intra-cellular uptake of Cbl by prolonging half-life of CD320.
PIK3CA is recurrently mutated in canine mammary tumors, similarly to in human mammary neoplasia
Authors: Arendt Maja Louise , Sakthikumar Sharadha , Melin Malin , Elvers Ingegerd , Rivera Patricio , Larsen Majbritt , Saellström Sara , Lingaas Frode , Rönnberg Henrik , Lindblad-Toh Kerstin
Published: January 2023

Biological features of neoplastic disease affecting mammary gland tissue are shared between canines and humans. Research performed in either species has translational value and early phase clinical trials performed in canines with spontaneous disease could be informative for human trials. The purpose of this study was to investigate the somatic genetic aberrations occurring in canine mammary neoplasia by exome capture and next generation sequencing. Based on 55 tumor-normal pairs we identified the PIK3CA gene as the most commonly mutated gene in canine mammary tumors, with 25% of samples carrying mutations in this gene. A recurrent missense mutation was identified, p.H1047R, which is homologous to the human PIK3CA hotspot mutation found in different types of breast neoplasia. Mutations homologous to other known human mutation hotspots such as the PIK3CA p.E545K and the KRAS p.G12V/D were also identified. We identified copy number aberrations affecting important tumor suppressor and oncogenic pathways including deletions affecting the PTEN tumor suppressor gene. We suggest that activation of the KRAS or PIK3CA oncogenes or loss of the PTEN suppressor gene may be important for mammary tumor development in dogs. This data endorses the conservation of cancer across species and the validity of studying cancer in non-human species.
Secretory leukocyte protease inhibitor and risk of heart failure in the Multi-Ethnic Study of Atherosclerosis
Authors: Sawicki Konrad Teodor , Nannini Drew R. , Bielinski Suzette J. , Larson Nicholas B. , Lloyd-Jones Donald M. , Psaty Bruce , Taylor Kent D. , Shah Sanjiv J. , Rasmussen-Torvik Laura J. , Wilkins John T. , McNally Elizabeth M. , Patel Ravi B.
Published: January 2023

Circulating protease inhibitors are important regulators of inflammation that are implicated in the pathophysiology of heart failure (HF). Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor which protects pulmonary tissues against inflammatory damage; however, its role in HF is not well understood. We sought to evaluate associations of circulating SLPI and genetically-mediated serum SLPI with incident HF and its subtypes in a multi-ethnic cohort of adults using clinical and genetic epidemiological approaches. Among 2,297 participants in the Multi-Ethnic Study of Atherosclerosis (MESA), each doubling of serum SLPI was independently associated with incident HF (HR 1.77; 95% CI 1.02–3.02; P = 0.04), particularly incident HF with preserved ejection fraction (HFpEF; HR 2.44; 95% CI 1.23–4.84; P = 0.01) but not HF with reduced ejection fraction (HFrEF; HR 0.95; 95% CI 0.36–2.46; P = 0.91). Previously reported circulating SLPI protein quantitative trait loci (pQTLs) were not associated with serum SLPI levels or incident HF among MESA participants. In conclusion, baseline serum SLPI levels, but not genetically-determined serum SLPI, were significantly associated with incident HF and HFpEF over long-term follow-up in a multi-ethnic cohort. Serum circulating SLPI may be a correlate of inflammation that sheds insight on the pathobiology of HFpEF.
Traffic flow digital twin generation for highway scenario based on radar-camera paired fusion
Authors: Li Yanbing , Zhang Weichuan
Published: January 2023

Autonomous driving is gradually moving from single-vehicle intelligence to internet of vehicles, where traffic participants can share the traffic flow information perceived by each other. When the sensing technology is combined with the internet of vehicles, a sensor network all over the road can provide a large-scale of traffic flow data, thus providing a basis for building a traffic digital twin model. The digital twin can enable the traffic system not only to use past and present information, but also to predict traffic conditions, providing more effective optimization for autonomous driving and intelligent transportation, so as to make long-term rational planning of the overall traffic state and enhance the level of traffic intelligence. The current mainstream traffic sensors, namely radar and camera, have their own advantages, and the fusion of these two sensors can provide more accurate traffic flow data for the generation of digital twin model. In this paper, an end-to-end digital twin system implementation approach is proposed for highway scenarios. Starting from a paired radar-camera sensing system, a single-site radar-camera fusion framework is proposed, and then using the definition of a unified coordinate system, the traffic flow data between multiple sites is combined to form a dynamic real-time traffic flow digital twin model. The effectiveness of the digital twin building is verified based on the real-world traffic data.
Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design
Authors: Thies Arne , Sunkara Vikram , Ray Sourav , Wulkow Hanna , Celik M. Özgür , Yergöz Fatih , Schütte Christof , Stein Christoph , Weber Marcus , Winkelmann Stefanie
Published: January 2023

We previously reported the successful design, synthesis and testing of the prototype opioid painkiller NFEPP that does not elicit adverse side effects. The design process of NFEPP was based on mathematical modelling of extracellular interactions between G-protein coupled receptors (GPCRs) and ligands, recognizing that GPCRs function differently under pathological versus healthy conditions. We now present an additional and novel stochastic model of GPCR function that includes intracellular dissociation of G-protein subunits and modulation of plasma membrane calcium channels and their dependence on parameters of inflamed and healthy tissue (pH, radicals). The model is validated against in vitro experimental data for the ligands NFEPP and fentanyl at different pH values and radical concentrations. We observe markedly reduced binding affinity and calcium channel inhibition for NFEPP at normal pH compared to lower pH, in contrast to the effect of fentanyl. For increasing radical concentrations, we find enhanced constitutive G-protein activation but reduced ligand binding affinity. Assessing the different effects, the results suggest that, compared to radicals, low pH is a more important determinant of overall GPCR function in an inflamed environment. Future drug design efforts should take this into account.
Assessment of diffusion-weighted MRI in predicting response to neoadjuvant chemotherapy in breast cancer patients
Authors: Hottat Nathalie A. , Badr Dominique A. , Lecomte Sophie , Besse-Hammer Tatiana , Jani Jacques C. , Cannie Mieke M.
Published: January 2023

To compare region of interest (ROI)-apparent diffusion coefficient (ADC) on diffusion-weighted imaging (DWI) measurements and Ki-67 proliferation index before and after neoadjuvant chemotherapy (NACT) for breast cancer. 55 women were enrolled in this prospective single-center study, with a final population of 47 women (49 cases of invasive breast cancer). ROI-ADC measurements were obtained on MRI before and after NACT and were compared to histological findings, including the Ki-67 index in the whole study population and in subgroups of “pathologic complete response” (pCR) and non-pCR. Nineteen percent of women experienced pCR. There was a significant inverse correlation between Ki-67 index and ROI-ADC before NACT (r = − 0.443, p = 0.001) and after NACT (r = − 0.614, p < 0.001). The mean Ki-67 index decreased from 45.8% before NACT to 18.0% after NACT (p < 0.001), whereas the mean ROI-ADC increased from 0.883 × 10–3 mm2/s before NACT to 1.533 × 10–3 mm2/s after NACT (p < 0.001). The model for the prediction of Ki67 index variations included patient age, hormonal receptor status, human epidermal growth factor receptor 2 status, Scarff-Bloom-Richardson grade 2, and ROI-ADC variations (p = 0.006). After NACT, a significant increase in breast cancer ROI-ADC on diffusion-weighted imaging was observed and a significant decrease in the Ki-67 index was predicted.

Clinical trial registration number: clinicaltrial.gov NCT02798484, date: 14/06/2016.
Technological properties and composition of volatile compounds in winter wheat malts grown with addition of seed meals into soil
Authors: Gasiński Alan , Pytlarz Elżbieta , Hamkało Oliwia , Kawa-Rygielska Joanna
Published: January 2023

Wheat malts are necessary to produce wheat beers. In this study, wheat was grown with addition of seed meals into the soil, to determine whether such agricultural practice could improve the quality of the grain and, therefore, improve the quality of wheat malt produced from these grains. It was determined, that malt produced from the grains of the winter wheat cultivated with the use of seed meals is characterised with improved technological properties, such as saccharification time, filtration time and extract content and some of the seed meals had a positive impact on the content of various volatile compounds present in the produced malts.
Overexpression of soybean microRNA156b enhanced tolerance to phosphorus deficiency and seed yield in Arabidopsis
Authors: Lu Guangyuan , Tian Zhitao , Hao Yifan , Xu Meihua , Lin Yongxin , Wei Jinxing , Zhao Yongguo
Published: January 2023

microRNAs (miRNAs) are endogenous small RNAs that are key regulatory factors participating in various biological activities such as the signaling of phosphorus deficiency in the plant. Previous studies have shown that miR156 expression was modulated by phosphorus starvation in Arabidopsis and soybean. However, it is not clear whether the over-expression of soybean miR156b (GmmiR156b) can improve a plant’s tolerance to phosphorus deficiency and affect yield component traits. In this study, we generated Arabidopsis transgenic lines overexpressing GmmiR156b and investigated the plant’s response to phosphorus deficiency. Compared with the wild type, the transgenic Arabidopsis seedlings had longer primary roots and higher phosphorus contents in roots under phosphorus-deficit conditions, but lower fresh weight root/shoot ratios under either phosphorus-deficient or sufficient conditions. Moreover, the GmmiR156b overexpression transgenic lines had higher phosphorus content in shoots of adult plants and grew better than the wide type under phosphorus-deficient conditions, and exhibited increased seed yields as well as strong pleiotropic developmental morphology such as dwarfness, prolonged growth period, bushy shoot/branching, and shorter silique length, suggesting that the transgenic lines were more tolerant to phosphorus deficiency. In addition, the expression level of four SQUAMOSA PROMOTER BINDING PROTEIN LIKE (SPL) genes (i.e., AtSPL4/5/6/15) were markedly suppressed in transgenic plants, indicating that they were the main targets negatively regulated by GmmiR156b (especially AtSPL15) and that the enhanced tolerance to phosphorus deficiency and seed yield is conferred mainly by the miR156-mediated downregulation of AtSPL15.
Optimization of injection molding process parameters for the lining of IV hydrogen storage cylinder
Authors: Li Jin , Zhao Chunjiang , Jia Fuliang , Li Shunyang , Ma Shaohua , Liang Jianguo
Published: January 2023

The hydrogen storage cylinder lining was taken as the research object. The injection model of the cylinder liner was developed employing 3D software, a two-cavity injection molding system was built, and Moldflow was utilized for analysis to determine the best combination of injection molding process parameters. The effects of injection process parameters (melt temperature, mold temperature, holding pressure, holding time and cooling time) on the evaluation index were analyzed by orthogonal experiment L16(45). The prediction data of IV hydrogen storage cylinder lining under different parameters were obtained by the range analysis method. The multi-objective optimization problem of injection molding process was transformed into a single-objective optimization problem by using the grey correlation analysis method. The optimal parameters such as melt temperature 270 °C, mold temperature 80 °C, packing pressure 55 MPa, packing time 20 s and cooling time 13 s were obtained. Taguchi method was adopted to obtain SNR (signal-to-noise ratio), while range and variance methods were used for analysis. The results showed that warpage was 0.4892 mm, the volume shrinkage was 12.31%, the residual stress in the first direction was 98.13 MPa, and the residual stress in the second direction was 108.1 MPa. The comprehensive index was simultaneously most impacted by the melt temperature.
Incidence, risk factors, and clinical characteristics of airway complications after lung transplantation
Authors: Kim Hyeon Hwa , Jo Kyung-Wook , Shim Tae Sun , Ji Wonjun , Ahn Jee Hwan , Oh Dong Kyu , Hong Sang-Bum , Yun Jae Kwang , Lee Geun Dong , Choi Sehoon , Kim Dong Kwan , Park Seung-Il , Kim Ho Cheol
Published: January 2023

Airway complications may occur after lung transplantation and are associated with considerable morbidity and mortality. We investigated the incidence, risk factors, and clinical characteristics of these complications. We retrospectively reviewed the medical records of 137 patients who underwent lung transplantation between 2008 and 2021. The median follow-up period was 20 months. Of the 137 patients, 30 (21.9%) had postoperative airway complications, of which 2 had two different types of airway complications. The most common airway complication was bronchial stenosis, affecting 23 patients (16.8%). Multivariable Cox analysis revealed that a recipient’s body mass index ≥ 25 kg/m2 (hazard ratio [HR], 2.663; p = 0.013) was a significant independent risk factor for airway complications, as was postoperative treatment with extracorporeal membrane oxygenation (ECMO; HR, 3.340; p = 0.034). Of the 30 patients who had airway complications, 21 (70.0%) were treated with bronchoscopic intervention. Survival rates did not differ significantly between patients with and without airway complications. Thus, our study revealed that one fifth of patients who underwent lung transplantation experienced airway complications during the follow-up period. Obesity and receiving postoperative ECMO are risk factors for airway complications, and close monitoring is warranted in such cases.
Active visual search in naturalistic environments reflects individual differences in classic visual search performance
Authors: Botch Thomas L. , Garcia Brenda D. , Choi Yeo Bi , Feffer Nicholas , Robertson Caroline E.
Published: January 2023

Visual search is a ubiquitous activity in real-world environments. Yet, traditionally, visual search is investigated in tightly controlled paradigms, where head-restricted participants locate a minimalistic target in a cluttered array that is presented on a computer screen. Do traditional visual search tasks predict performance in naturalistic settings, where participants actively explore complex, real-world scenes? Here, we leverage advances in virtual reality technology to test the degree to which classic and naturalistic search are limited by a common factor, set size, and the degree to which individual differences in classic search behavior predict naturalistic search behavior in a large sample of individuals (N = 75). In a naturalistic search task, participants looked for an object within their environment via a combination of head-turns and eye-movements using a head-mounted display. Then, in a classic search task, participants searched for a target within a simple array of colored letters using only eye-movements. In each task, we found that participants’ search performance was impacted by increases in set size—the number of items in the visual display. Critically, we observed that participants’ efficiency in classic search tasks—the degree to which set size slowed performance—indeed predicted efficiency in real-world scenes. These results demonstrate that classic, computer-based visual search tasks are excellent models of active, real-world search behavior.
Differential effects of low and high temperature stress on pollen germination and tube length of mango (Mangifera indica L.) genotypes
Authors: Liu Xinyu , Xiao Yilin , Zi Jing , Yan Jing , Li Chunhong , Du Chengxun , Wan Jiaxin , Wu Hongxia , Zheng Bin , Wang Songbiao , Liang Qingzhi
Published: January 2023

Mango flowering is highly sensitive to temperature changes. In this research, the maximum values of pollen germination rate (PGR), pollen tube length (PTL) and their cardinal temperatures (Tmin, Topt and Tmax) were estimated by using quadratic equation and modified bilinear model under the conditions of 14–36 °C. The pollen germination rate in four mango varieties ranged from 29.1% (‘Apple mango’) to 35.5% (‘Renong No. 1’); the length of pollen tube ranged from 51.2 μm (‘Deshehari’) to 56.6 μm (‘Jinhuang’). The cardinal temperatures ranges (Tmin, Topt and Tmax) of pollen germination were 20.3–22.8 °C, 26.7–30.6 °C and 30.4–34.3 °C, respectively; similarly, cardinal temperatures (Tmin, Topt and Tmax) of pollen tube growth were 20.3–21.2 °C, 27.9–32.1 °C and 30.2–34.4 °C respectively. Of those, ‘Renong No. 1’ could maintain relatively high pollen germination rate even at 30 °C, however, ‘Deshehari’ had the narrowest adaptive temperature range. These results were further confirmed by changes of superoxide dismutase, catalase activity and malondialdehyde content. These results showed that mango flowering was highly sensitive to temperature changes and there were significant differences in pollen germination rate and pollen tube length among different varieties. Current research results were of great significance for the introduction of new mango varieties in different ecological regions, the cultivation and management of mango at the flowering stage and the breeding of new mango varieties.
Synergistic effects of l-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation
Authors: Xu Wei , Song Xianying , Qu Qingyun , Gong Zhihua , Xiao Wenjun
Published: January 2023

Ovalbumin (OVA), a commonly consumed food protein, can cause severe allergies and intestinal immune disorders.
Identification of umami peptides based on virtual screening and molecular docking from Atlantic cod (Gadus morhua)
Authors: Wang Yuanyuan , Luan Junjia , Tang Xuhua , Zhu Wenhui , Xu Yongxia , Bu Ying , Li Jianrong , Cui Fangchao , Li Xuepeng
Published: January 2023

Umami peptides have currently become the research focus in the food umami science field and the key direction for umami agent development.
Turbulence-induced vibrations prediction through use of an anisotropic pressure fluctuation model
Authors: van den Bos Nout , Zwijsen Kevin , van Zuijlen Alexander H. , Frederix Edo M.A , Roelofs Ferry
Published: January 2023

In nuclear fuel rod bundles, turbulence-induced pressure fluctuations caused by an axial flow can create small but significant vibrations in the fuel rods, which in turn can cause structural effects such as material fatigue and fretting wear. Fluid-structure interaction simulations can be used to model these vibrations, but for affordable simulations based on the URANS approach, a model for the pressure fluctuations must be utilised. Driven by the goal to improve the current state-of-the-art pressure fluctuation model, AniPFM (Anisotropic Pressure Fluctuation Model) was developed. AniPFM can model velocity fluctuations based on anisotropic Reynolds stress tensors, with temporal correlation through the convection and decorrelation of turbulence. From these velocity fluctuations and the mean flow properties, the pressure fluctuations are calculated. The model was applied to several test cases and shows promising results in terms of reproducing qualitatively similar flow structures, as well as predicting the root-mean-squared pressure fluctuations. While further validation is being performed, the AniPFM has already demonstrated its potential for affordable simulations of turbulence-induced vibrations in industrial nuclear applications.
Research on The Offensive Characteristics of La Liga Team Based on Social Network Analysis
Authors: Du Wei , Li Jingwen , Li Feiyu
Published: January 2023

To explore the difference of social network parameters between the network of passing before scoring and the network of passing before missing the goal, and to explore the correlation between social network parameters and team performance, this paper establishes the offensive pass network of 20 teams in the La Liga from 2017 to 2018, and 11 social network parameters are calculated. The Pearson correlation test is used to explore the linear correlation between 11 social network parameters and team performance. The results show that the linear correlation between the network parameters of passing before scoring and team performance is stronger than the network parameters of passing before missing the goal. According to the results, we can provide reliable and effective information to the football coaches to help improve the performance of football matches.
The Impact of Taobao’s Negative Comments on Consumer Willingness
Authors: Sun Liyuxi
Published: January 2023

Based on the theory of trust orientation and perceived risk, this study explores the impact of Taobao’s negative evaluation on consumer behaviour, and then conducts research. According to the theory of trust tendency, this paper discusses how consumers view the negative evaluation of goods. Through data analysis, it is found that consumers will have lower purchase intention when they browse negative comments. The psychological mechanism of this is that consumers are affected by perceived risks, resulting in lower brand identity. The subjects of this study are 70 Taobao users, and the hypothesis proposed is tested through correlation analysis.
Exploring the Communication Strategy of Intangible Cultural Heritage in the New Media Context
Authors: Meng Mei
Published: January 2023

As the pearl of China’s intangible cultural heritage, there are still many difficulties in the development of opera. This paper takes Meilin opera of Sanming City, Fujian Province, as an example, analyzes the current situation of the inheritance of Meilin opera in the context of “Internet+”, and compares it with the development of similar operas, and finally discusses the new strategies for the protection and development of intangible cultural heritage such as opera from the perspective of communication path and communication mechanism.
Research on the Use of Social Media to Grasp Consumers’ Psychology and Create Traffic: A Case Study of Brandy Melville
Authors: Liu Zheran
Published: January 2023

In recent years, Brandy Melville (Hereinafter referred to as BM), an Italian clothing brand, has gained popularity in mainland China because of the style of its slim tops and skirts, which echos the “freedom to dress” speech that has been popular in recent years. However, BM only produces one size and only girls who are thin enough can wear it. This makes other girls feel that their bodies are not recognized. Therefore, BM is also known as the “creator of body anxiety”. Nevertheless, wearing BM has become a hint to prove one’s “good figure”, and BM’s marketing strategy also cleverly utilizes consumers’ vanity to achieve the purpose of marketing itself. So even though there are a lot of critical comments, BM is still gaining popularity from the public. The purpose of this case study is to explore how Brandy Melville grasps consumers’ psychology and controls their emotions, and how it takes advantage of hot comments and critical comments to build its own image and drive consumers to buy. Through the case study of Brandy Melville and the interview with its audience and Key Opinion Leaders (KOLs), this paper aims to find out how social media is used to influence and guide the public’s psychology and emotions. Results show that social media can be used to build the brand image, lead the fashion trend, echo hot topics, and create public sentiment to grasp consumer’s psychology and create traffic.
Urban Communication Strategy Based on Short Video Platform: A Case Study of TikTok
Authors: Wang Xueyi
Published: January 2023

The concept of urban communication bred in the new media era takes short video platforms as the vehicle for emerging Internet-famous cities. The internal relationship between the communication strategy and development orientation of urban communication and the image practice and performance space of short videos is worth studying. Taking Chongqing and Xi’an as the research objects, this paper explores the operation mode and communication concept of urban space in the new media era from the perspectives of communication origin, user participation, and in-depth communication. The research shows that the advent of mobile short-video platforms offers a new vehicle and channel for the communication and reconstruction of urban space and enriches the audience’s cognition of city images.
Research on the Tax Dilemma of Network Broadcast Industry and Countermeasures
Authors: Yayi Li , Yi-ting Liu , Jing-yi Zhang
Published: January 2023

With the rapid development of new forms of Internet business, the network broadcast industry has gradually become the tuyer. The huge tax evasion event of network anchors such as Huang Wei and Lin Shanshan broke out, which caused huge social public opinion, but also reflected that there are many special difficulties in the tax work of network broadcast industry at present. However, the existing tax collection and administration system of China can not adapt to the needs of the emerging industry, which induced a series of tax evasion events. This paper will grasp the particularity of the tax work in the network live broadcast industry and analyze the realistic difficulties encountered by the tax authorities in the taxation of network broadcast industry, and put forward the countermeasures for the situation of our country based on the international advanced experience, and propose a new way to deeply integrate the tax work and high-tech.
Exploring the Effects of Overload and Stress Factors on WeChat Moments Users’ Discontinuous Usage Intention: an SSO Perspective
Authors: Zhang Qianrun
Published: January 2023

This study explores the factors that contribute to social media fatigue and how it affects users’ intentions to stop regularly using their WeChat Moments. The findings demonstrate that information overload, social overload, system feature overload, and upward social comparison (stressors) impact social media fatigue (Strain) and ultimately impact the decision to discontinue using WeChat Moments. Social media fatigue acts as a buffer between the stressors of social interaction and the outcome. Users who bear the pressure of the opinion leader role and have low clustering coefficients in the ego network are more likely to express the desire to discontinue using WeChat Moments.
Exploration of Government Collaboration in the Co-Location of Guangzhou and Foshan
Authors: He MuChuan
Published: January 2023

The basic feature of China’s economic development in the new era is the shift from the stage of high-speed growth to the stage of high-quality development, and the concept of crosstownization is developed in the context of economic globalization and regional economic integration. Co-location is a requirement of the times, and the essence is close cooperation between cities and towns to achieve good and fast development. This paper explores the governmental collaboration aspect of the Guangzhou-Foshan co-location, discussing three aspects: the current situation, problems and suggestions, analyzing the current situation of the development of the Guangzhou-Foshan co-location, the main problems and putting forward suggestions for future development.
Technological-progress and accident-drive: the presentation of the topic of “medical beauty” in the domestic media——the media reports of “People’s Daily”, “Southern Metropolis Daily” and “China Women’s Daily” as examples (2000-2022)
Authors: Zeng Kaiyin
Published: January 2023

Based on the framework theory, this study takes “People’s Daily”, “Southern Metropolis Daily” and “China Women’s Daily” three traditional media with different positioning as examples, to have a glimpse of their media discourse presentation and practice of “medical beauty”. Through content analysis, it is found that the media presentation of medical and aesthetic topics is mainly driven by events, and its positive aspects are not only reflected in the possibility of providing people with the chance to change their lives and destiny, but also tied to the discourse of technological nationalism. There are significant differences in the framework and topic focus of different media. People’s Daily pays more attention to constructive perspectives such as industrial economic framework and governance, while media such as Southern Metropolis Daily lays more emphasis on accidental issues that can draw the attention of the audience.
Visual Truth and Image Manipulation: Visual Ethical Anomie and Reconstruction of Digital Photography
Authors: Wang Xia , Hu Qianqian
Published: January 2023

Digital photography has impacted the visual truth in terms of image operation technology. The paper analyzes the performance of image manipulation in digital photography, and asserts that the operation image’s resolution of visual truth can be described by three aspects: the fact deviation, the reconstruction of the situation, the trust crisis, the filter survival, the second reprint, and the value change. Consequently, there are three visual ethical problems associated with the manipulation of images by technology, the siege of images on people, and distortions of social order caused by the manipulation of images by technology. Thus, it is suggested that visual ethics be reconstructed from three perspectives: reconstructing the dominant role of human beings in the digital era, returning to the original significance of visual images, and constructing multiple visual structures.
Research on the application status of image recognition technology in textile and clothing field
Authors: Ren Mingzhen , Liu Yajie , Ma Xinmin
Published: January 2023

With the development of the times, computer, information technology gradually penetrated into all walks of life. Textile and clothing design, production, consumption integration of machine vision, graphic image recognition technology development have become a trend. At present, the intelligence degree of the textile and clothing industry has reached an unprecedented new height. In the production and identification of fabrics, the machine vision gradually replaces the manual work, and realizes the automatic and accurate production line. In the design, manufacturing, consumption and other aspects of clothing, image recognition technology has assumed the historical responsibility. Combined with the Internet of things, cloud computing and other technologies, it has improved the production efficiency and achieved intelligent design and production.
Study of two-electron temperature plasma sheath using non-extensive electron distribution in presence of an external magnetic field
Authors: Sharma Gunjan , Paul Rupali , Deka Kishor , Moulick Rakesh , Adhikari Sayan , Kausik S. S. , Saikia B. K.
Published: January 2023

In this study, the physics of sheath formation in a collisional two-electron temperature plasma in the presence of an oblique external magnetic field has been investigated. At first, a comparative study among the fluid electron model, Boltzmann electron model, and the non-extensive electron model has been carried out and a suitable range of non-extensive parameter q has been predicted. In the latter part, a collisional two-electron temperature plasma is considered. Both the hot and cold electron densities are described using the non-extensive distribution, whereas cold ions are described by the fluid equations. The properties of the sheath are investigated in different collisional regimes by varying the non-extensive parameter (q) and the hot to cold electron densities and temperatures. The magnetic field inclination angle is varied in the limit 1° ≤ α ≤ 5°. It is observed that electron distribution significantly deviates from Boltzmann distribution for nearly parallel magnetic field. Moreover, collision enhanced flux deposition for highly magnetized case is a significant finding of the study. The results obtained in this study can enhance the understanding of plasma–matter interaction processes where multiple electron groups with near parallel magnetic field are found.
Investigation of friction coefficient to improve traction condition in R2R transport system
Authors: Shin Woojoo , Kim Myungsung , Lee Taehyun , Kang Dongwoo , Shim JaeWon , Kim Yongjin
Published: January 2023

In a roll-to-roll (R2R) system, the roller’s traction force for precision transportation is crucial for the commercialization of printed electronic devices. Moreover, greater traction force of the roller can prevent several issues, such as slippage, wrinkles, sagging, and air entrainment, which occur because of insufficient traction force. The wrap angle, tension, and friction coefficient between the roller and the transporting film are key factors for achieving greater traction force in an R2R transport system. However, design of the wrap angle and tension are limited by the film damage and complex arrangement of the rollers. For these reasons, this study focused on the method that increases the friction coefficient on the surface of the roller. We applied three methods—normal force, static electricity, and thin polydimethylsiloxane coating—on the surface of the roller. Then, we suggest an effective means of improving the friction coefficient to supplement the design restrictions of tension and the wrap angle in R2R transport systems.
Enhancement of electrical conductivity of Zn4Sb3 by addition of ZnO particles
Authors: Tahashi Masahiro , Goto Hideo
Published: January 2023

We have investigated the effect of the addition of 50 nm ZnO particles on the thermoelectric material Zn4Sb3 from the view point of the electrical conduction. The conductivity of Zn4Sb3 reached its maximum value upon the addition of 0.3 wt. % of ZnO particles. This value was four times larger than that of the undoped sample. The mobility also displayed the same trend as the conductivity, indicating that the change in the conductivity of Zn4Sb3 by the addition of ZnO particles was attributable to the ZnO content dependence of the mobility.
Origin of enhanced conductivity in low dose ion irradiated oxides
Authors: Borgersen Jon , Karsthof Robert , Rønning Vegard , Vines Lasse , von Wenckstern Holger , Grundmann Marius , Kuznetsov Andrej Yu , Johansen Klaus Magnus
Published: January 2023

Significant resistivity variations have previously been observed in oxides subjected to relatively low ion irradiation doses, nominally insufficient to generate the amount of bulk defects needed to explain the phenomena. In an effort to unveil the underlying mechanisms, we performed a systematic comparative study of the resistivity evolution in In2O3-based oxides as a function of low ion doses and ultraviolet (UV) illumination, observing striking correlations. Specifically, we found that irradiation with ∼3 × 1012 Si/cm2 and ∼18 h UV exposure result in similar resistivity drops, interpreted in terms of irradiation/illumination assisted desorption of oxygen containing species from the surface. This was further proven by post-irradiation exposure of one of the samples to an oxygen atmosphere partially restoring the resistivity. Combining the present results with literature data, we conclude that the radiation tolerance of In2O3-based and similar oxides depends on the surface charge modifications, individual defect contributions, and contributions from defect complexes at low, intermediate, and high doses, respectively.
Phase engineering in tantalum sulfide monolayers on Au(111)
Authors: Dombrowski Daniela , Samad Abdus , Mehlich Kai , Chagas Thais , Schwingenschlögl Udo , Busse Carsten
Published: January 2023

We prepare monolayers of tantalum sulfide on Au(111) by evaporation of Ta in a reactive background of H2S. Under sulfur-rich conditions, monolayers of 2H-TaS2 develop, whereas under sulfur-poor conditions TaS forms, a structure that can be derived from 2H-TaS2 by removal of the bottom S layer. We analyze the alignment of the layers with respect to the substrate and the relation with the domains in the Au(111) herringbone reconstruction using scanning tunneling microscopy. With the help of density functional theory calculations we can determine the registry of the two phases with the substrate. We develop a growth process that allows preparation of uniquely oriented 2H-TaS2 on Au(111). 2H-TaS2 and TaS have a remarkably similar in-plane lattice structure and we observe the formation of lateral 2H-TaS2-TaS heterostructures with atomically well-defined and defect-free boundaries. We observe mirror twin boundaries within 2H-TaS2 along the S- and Ta-edge.
Measuring pants
Authors: Doan Nhat Minh , Parlier Hugo , Tan Ser
Published: January 2023

We investigate the terms arising in an identity for hyperbolic surfaces proved by Luo and Tan, namely showing that they vary monotonically in terms of lengths and that they verify certain convexity properties. Using these properties, we deduce two results. As a first application, we show how to deduce a theorem of Thurston which states, in particular for closed hyperbolic surfaces, that if a simple length spectrum “dominates” another, then in fact the two surfaces are isometric. As a second application, we show how to find upper bounds on the number of pairs of pants of bounded length that only depend on the boundary length and the topology of the surface.