bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiple Tobacco Product Use among Adolescents with Asthma in Korea
Authors: Kim Seokhwan , Jo Kyuhee
Published: August 2022

Few studies have examined the use of multiple tobacco products among adolescents with asthma. The purpose of this study was to examine multiple tobacco product use and smoking behaviors. In this study, data from the Korea Youth Risk Behavior Web-based Survey (KYRBWS) were used, and 57,303 samples from 400 middle schools and 400 high schools in Korea were classified as study participants. Statistical analysis was performed with a complex sample design, using frequency analysis, chi-square test, and multiple logistic regression analysis. Adolescents with asthma had a higher current smoking rate for combustible cigarettes (CC), e-cigarettes (EC), and heated tobacco products (HTPs) than those without asthma (p < 0.001). The rates of dual use (using two types of tobacco; CC + EC or CC + HTPs or EC + HTPs; OR = 2.62, 95% CI: 1.626–4.240, R2 = 26.8%) and triple use (using three types of tobacco; CC + EC + HTPs; OR = 2.61, 95% CI: 1.678–4.065, R2 = 34.9%) were higher in adolescents with asthma than those without asthma, after adjusting for confounders. The smoking rate of new types of tobacco among adolescents with asthma is on the rise. Therefore, the calculation of basic data related to new tobacco smoking among adolescents is essential for establishing a continuous monitoring system to alleviate the burden of disease on national health.
Effect of Flexible Sacrum Position on Maternal and Neonatal Outcomes in Public Health Facilities, Amhara Regional State, Ethiopia: A Quasi-Experimental Study
Authors: Badi Marta Berta , Abebe Solomon Mekonnen , Weldetsadic Mulat Adefris , Christensson Kyllike , Lindgren Helena
Published: August 2022

Restricting women giving birth in health care facilities from choosing the most comfortable position during labor and birth is a global problem. This study was aimed to examine the effect of flexible sacrum birth positions on maternal and neonatal outcomes in public health facilities in Ethiopia’s Amhara Region. A non-equivalent control group post-test-only design was employed at public health facilities from August to November 2019. A total of 1048 participants were enrolled and assigned to intervention or control groups based on their choice of birth position. Participants who preferred the flexible sacrum birth position received the intervention, while participants who preferred the supine birth position were placed in the control group. Data were collected using observational follow-up from admission to immediate postpartum period. Log binomial logistic regression considering as treated analysis was used. Of the total participants, 970 women gave birth vaginally, of whom 378 were from the intervention group, and 592 were from the control group. The intervention decreased the chance of perineal tear and poor Apgar score by 43 and 39%, respectively. The flexible sacrum position reduced the duration of the second stage of labor by a mean difference of 26 min. Maternal and newborn outcomes were better in the flexible sacrum position.
How Is It to Live with Diabetes Mellitus? The Voices of the Diabetes Mellitus Clients
Authors: Ngoatle Charity , Mothiba Tebogo Maria
Published: August 2022

Background: Diabetes mellitus is described as a chronic disease resulting from failure of the pancreas to generate enough insulin or inability of the body to efficiently utilize the insulin it generates. Diabetes clients must adjust their lives to live healthy with the diseases for the rest of their lives. Optimizing diabetic knowledge and awareness among people living with diabetes will yield better health outcomes. This study seeks to investigate the knowledge, practices, and challenges of diabetes mellitus clients regarding management of the disease at selected clinics in the Capricorn District of Limpopo Province, South Africa. Methods: This study used a qualitative research approach and a phenomenological research design. A purposive sampling method was used to acquire the 18 participants for this study. Semi-structured interviews with a guide were used to collect data. Tesch’s coding method was employed for data analysis. Results: The study findings revealed that there are comparable explanations of what it means to follow medication instructions by diabetes mellitus clients, and challenges living with DM. The findings also indicate that there are problems related to conceptualization of medication instructions among diabetes clients. Conclusion: This study indicated that diabetes mellitus clients have poor knowledge regarding management of the disease and its process, and problems related to medication instructions. Therefore, proper teaching of clients and guidance regarding diabetes and its management are required to improve compliance and delay of long-term complications.
Influence of Smartphone-Based Digital Extension Service on Farmers’ Sustainable Agricultural Technology Adoption in China
Authors: Li Baozhi , Zhuo Ni , Ji Chen , Zhu Qibiao
Published: August 2022

The literature about how Information and Communication Technologies (ICTs) influence farmers’ adoption of sustainable agricultural technology is emerging, studies regarding the effects of particular smartphone-based digital extension services on farmers’ sustainable agricultural technology practices are limited. This study investigates the relationship between a digital extension service (“Zhe’ yang’ shi” WeChat application) and the adoption of soil testing and formula fertilization, a precision fertilization technology. A household choice model is constructed to explain the impact of the application. Based on a household-level data set from a survey of 400 farmers in Zhejiang in 2022, empirical results show that the use of the “Zhe’ yang’ shi” WeChat application significantly increases the adoption of soil testing and formula fertilization. We also discuss the heterogeneous effect by different production scales. The findings enrich the literature regarding ICTs’ influence on farmers’ behavior in adopting sustainable agricultural technology. It provides a valuable example for developing countries to promote sustainable agriculture through digital technology.
Development and Validation of the COVID-19-Related Stigma Scale for Healthcare Workers (CSS-HCWs)
Authors: Tsukuda Makoto , Ito Yoshiyasu , Nojima Keisuke , Kayano Tomonori , Honda Junko
Published: August 2022

Stigma among healthcare workers during the coronavirus disease 2019 (COVID-19) pandemic is an issue that requires immediate attention, as it may otherwise lead to the collapse of healthcare systems. In this study, we developed the COVID-19-related stigma scale for healthcare workers (CSS-HCWs) and assessed its reliability and validity. Data were collected online from 500 participants, including physicians and nurses involved in COVID-19 care. The first item of the draft scale was developed based on a literature review and qualitative study. The draft scale consisted of 24 items, which were rated on a six-point Likert scale. Descriptive statistics were calculated and the data distribution was analyzed. To assess the scale’s validity and reliability, structural validity was evaluated through an exploratory factor analysis. Criterion-related validity was examined through a correlation analysis using the E16-COVID19-S, a COVID-19 scale developed for physicians in Egypt. Reliability was evaluated by examining the scale’s stability and internal consistency. The findings revealed that the stigma scale was a valid and reliable instrument. The final scale consisted of 18 items across three domains: personal stigma, concerns of disclosure and others, and family stigma. In conclusion, the scale is a valid and reliable instrument that can measure COVID-19-related stigma among healthcare workers.
Healthy Environments: Understanding Perceptions of Underrepresented Communities in the United Kingdom
Authors: Roberts Lily F. , Lounsbury Olivia , Awuzudike Veronica , Jennings Neil , Lawrance Emma L.
Published: August 2022

A healthy environment has been defined by global health organisations as one that is safe, supportive of healthy lifestyles, and free of hazards. Such definitions disregard the complexity of what it means for an environment to be perceived as ‘healthy’—such as the mental, not just physical, health effects on citizens. This study aimed to understand the attributes that underrepresented groups of the United Kingdom (UK) public assign to healthy environments—an important step for directing public policy and actions to create environments that are inclusive of all citizens. This co-created study involved 95 participants from underrepresented communities in 10 separate focus groups, each facilitated by a community member. Thematic analyses highlighted five key attributes of a healthy environment: sounds and sights, accessibility, safety, familiarity and mental health and wellbeing. This study draws a picture of key attributes underrepresented groups of the UK public assign to healthy environments that is richer than that drawn by existing definitions. These findings illustrate the importance of hearing diverse voices when directing research, policy, and actions that attempt to develop healthy environments for all.
The Top 100 Most Cited Scientific Papers in the Public, Environmental & Occupational Health Category of Web of Science: A Bibliometric and Visualized Analysis
Authors: Hernández-González Vicenç , Carné-Torrent Josep Maria , Jové-Deltell Carme , Pano-Rodríguez Álvaro , Reverter-Masia Joaquin
Published: August 2022

(1) Background: The main basis for the public recognition of the merits of scientists has always been the system of scientific publications and citations. Our goal is to identify and analyze the most cited articles in the Public, Environmental & Occupational Health category. (2) Methods: We searched the Web of Science for all articles published in the “Public, Environmental & Occupational Health” category up to March 2022 and selected the 100 most cited articles. We recorded the number of citations, the journal, the year of publication, quartile, impact factor, institution, country, authors, topic, type of publication and collaborations. (3) Results: 926,665 documents were analyzed. The top 100 had 401,620 citations. The journal with the most articles was the Journal of Clinical Epidemiology and the one with the highest number of citations was Medical Care. The year with the highest number of articles in the top 100 was 1998. The country with the highest percentage of publications was the USA and the most productive institution was Harvard. The most frequent keywords were bias, quality, and extension. The largest collaboration node was between the USA, Canada, Germany, Spain, Australia, France, and Sweden. (4) Conclusions: This bibliometric study on Public, Environmental & Occupational Health provides valuable information not only to identify topics of interest in the analyzed category, but also to identify the differences in the topics they study.
Stress Response and Safe Driving Time of Bus Drivers in Hot Weather
Authors: Sun Xianglong , Dong Junman
Published: August 2022

Purpose: To evaluate the impact of high-temperature environments on bus drivers’ physiology and reaction times, and to provide a basis for driver occupational health management. Methods: The physiological and reaction indexes of 24 bus drivers under different temperatures were investigated. The statistical analysis method was used to analyze the changes in drivers’ physiological stress, the relationship between stress and response ability, and a safe driving time. The Kaplan–Meier survival function was used to analyze the survival rate of bus drivers under different temperatures and driving times. Results: The results showed that body temperature, heart rate, physiological strain index (PSI), and reaction ability were significantly different among different compartment temperatures. PSI was positively correlated with reaction ability. The safe driving time was 80 min, 73 min, and 53 min, respectively, at 32 °C, 36 °C, and 40 °C. The survival rate decreased to less than 60% at 36 °C when driving continuously for 73 min; it decreased to 20% at 40 °C when driving for 53 min, and it was 0 for 75 min. Conclusions: High-temperature environments lead to heat stress of bus drivers, physiological indexes have changed significantly, and behavioral ability is also decreased. The higher the temperature, the lower the survival rate. Improvement measures can be taken from the aspects of convection, conduction, and behavior to ensure the bus driver’s physiological health and driving safety under high temperatures and to improve the survival rate.
A Prospective Comparative Analysis Regarding the Assessment of Oral Mucosal Disease Using a Validated Questionnaire to Improve the Teaching of Dental Students
Authors: Roeschmann Nico , Rau Andrea , Kesting Marco R. , Maier Eva , Buchbender Mayte
Published: August 2022

Structured examination and treatment are essential in medicine. For dental students, a structured approach to the assessment of oral mucosal lesions is missing thus far. To validate an approach, a structured questionnaire was compared with the habitually used free description of oral lesions (white lesions, ulcers, hyperplasia). Thirty-three dental students were divided into two groups (Group 1 (n = 17) used the free description; Group 2 (n = 16) used a guided questionnaire) to characterize mucosal lesions in patients and make a tentative diagnosis. Although no difference was found between the groups regarding the suspected diagnosis or the histopathological findings, there was a significant advantage of the structured questionnaire in all aspects of the description compared to the free description (p = 0.000018). Thus, a structured description is an important aspect in the evaluation of oral mucosal changes, and a guided questionnaire should be implemented in the study of dentistry.
Online Peer-Support Group’s Role in Addressing Filipino Domestic Workers’ Social Support Needs: Content and Social Media Metrics Analysis
Authors: Cheng Qijin , Vicera Christine
Published: August 2022

The study aimed to examine what types of social support a prominent online peer support group has provided to Filipino domestic workers (FDWs) in Hong Kong (HK), how impactful each type of support was, and to what extent the support could address group members’ expressed needs. Posts published from 1 September 2021 to 31 December 2021 in one of the largest online peer-support groups for FDWs in HK and their meta-data were extracted from Facebook. Thematic content analysis was performed to extract relevant information from the posts. Descriptive statistical analysis on the social media metrics was conducted to measure post impacts. A total of 599 posts published over the study period can be categorized to provide informational (76.67%), emotional (33.56%), and instrumental support (13.52%). Posts including emotional support were often more impactful. A total of 58 posts responded to requests explicitly expressed by individual FDWs, of which 13 required external resources. The online peer-support group acts as a new channel to raise FDWs’ awareness of important issues related to their well-being, to encourage and facilitate them to seek formal and informal help, and to keep them emotionally attended to. Formal support services should recognize and collaborate with them and support their long-term sustainability.
Use of Artificial Intelligence to Manage Patient Flow in Emergency Department during the COVID-19 Pandemic: A Prospective, Single-Center Study
Authors: Arnaud Emilien , Elbattah Mahmoud , Ammirati Christine , Dequen Gilles , Ghazali Daniel Aiham
Published: August 2022

Background: During the coronavirus disease 2019 (COVID-19) pandemic, calculation of the number of emergency department (ED) beds required for patients with vs. without suspected COVID-19 represented a real public health problem. In France, Amiens Picardy University Hospital (APUH) developed an Artificial Intelligence (AI) project called “Prediction of the Patient Pathway in the Emergency Department” (3P-U) to predict patient outcomes. Materials: Using the 3P-U model, we performed a prospective, single-center study of patients attending APUH’s ED in 2020 and 2021. The objective was to determine the minimum and maximum numbers of beds required in real-time, according to the 3P-U model. Results A total of 105,457 patients were included. The area under the receiver operating characteristic curve (AUROC) for the 3P-U was 0.82 for all of the patients and 0.90 for the unambiguous cases. Specifically, 38,353 (36.4%) patients were flagged as “likely to be discharged”, 18,815 (17.8%) were flagged as “likely to be admitted”, and 48,297 (45.8%) patients could not be flagged. Based on the predicted minimum number of beds (for unambiguous cases only) and the maximum number of beds (all patients), the hospital management coordinated the conversion of wards into dedicated COVID-19 units. Discussion and conclusions: The 3P-U model’s AUROC is in the middle of range reported in the literature for similar classifiers. By considering the range of required bed numbers, the waste of resources (e.g., time and beds) could be reduced. The study concludes that the application of AI could help considerably improve the management of hospital resources during global pandemics, such as COVID-19.
Evolution of Legislation and the Incidence of Elective Abortion in Spain: A Retrospective Observational Study (2011–2020)
Authors: Pellico-López Amada , Paz-Zulueta María , Manjón-Rodríguez Jimena B. , Sánchez Movellán Mar , Ajo Bolado Purificación , García-Vázquez José , Cayón-De las Cuevas Joaquín , Ruiz-Azcona Laura
Published: August 2022

Background: According to the WHO, “unsafe abortion occurs when a pregnancy is terminated either by people lacking the necessary skills or in an environment that does not conform to minimal medical standards, or both”. Aim: To review the legislation that ensures access to elective abortion and the main indicators of elective abortion in Spain. Methods: A retrospective observational study was conducted across all regions of Spain from 2011 to 2020. The regulations of each region on the creation of the clinical committee and the creation of the registry of conscientious objector professionals were identified. Data were collected on rates of elective abortions per 1000 women, type of health center where the intervention was performed, interval of weeks of gestation, and cause. Results: After Law 2/2010 entered into force, the Spanish regions created a clinical committee; however, very few regions have a registry of conscientious objectors. During the study period, the average annual rate in Spain was 11.10 elective abortions per 1000 women between 15 and 44 years of age, showing a decreasing trend (annual percentage change of −1.92%). Only 10.67% of abortions were performed at public centers. In 90.18% of the cases, abortions were performed at the woman’s request. Conclusion: Spain legislated late compared to most European Union countries. The current law is similar to that of other member states, allowing abortion at the woman’s request in the first fourteen weeks and thereafter for medical reasons. Most abortions are performed at private centers, although many territorial inequalities are observed.
Emission Trading System, Carbon Market Efficiency, and Corporate Innovations
Authors: Zhu Rui , Long Liyu , Gong Yinghua
Published: August 2022

Taking China’s emission trading system (ETS) pilot in 2013 as a quasi-natural experiment, this paper uses the difference-in-differences (DID) models to study whether the regional pilot ETS can promote technological innovation in enterprises. In addition, this paper examines the influence mechanism of the ETS innovation effect, with a focus on three key dimensions of the carbon market efficiency: market price effectiveness, market product diversity, and market order normativity. The results show that the pilot ETS has significantly promoted the technological innovation of regulated enterprises, specifically, 1.405*** for the total R&D investment, and 2.783*** for the number of patent applications. Moreover, the regional carbon price has a positive moderating effect on the innovation effect of ETS. Meanwhile, the innovation effect is more significant when the gap between the carbon price and the marginal abatement cost (MAC) of CO2 is smaller, when the carbon financial derivatives are more abundant, or when the local market supervision is stronger. This study provides empirical evidence for the improvement of the national unified market and provides useful policy implications for developing countries to design ETS suitable for their national conditions.
A New Approach for Constructing a Health Care Index including the Subjective Level
Authors: Jaworeck Sandra
Published: August 2022

Until now, health care systems have been compared by means of macro criteria, an approach that might have its shortcomings in assessing the actual benefits that health care systems may provide for people. Therefore, a new health care index is presented which combines individual assessments of health care systems with objective macro health care system criteria. Two steps are taken for furthering this approach: First, a data-driven procedure is used to determine the influence of self-rated health on confidence in the health care system through macro criteria of health care systems. The macro indicators are weighted accordingly and created into an index, which adds to the subjective level of the link. In a second step, the constructed health care index is tested in a multilevel model with self-rated health being the dependent variable, to avoid tautological conclusions. The index is able to reduce country differences, decrease explained variability and has a statistically significant effect without affecting other estimates.
The Origin, Application and Mechanism of Therapeutic Climbing: A Narrative Review
Authors: Liu Sheng , Gong Xiaoqin , Li Hanping , Li Yuan
Published: August 2022

As an innovative exercise therapy, therapeutic climbing (TC) has attracted more attention than ever before in recent years. In this review of the related studies on TC, the authors explore its origin and development; summarize its therapeutic effect in treating depression, low back pain and other diseases; and further analyze its underlying mechanism. According to the literature, TC was primarily applied in the field of orthopedics and then was gradually used in neurology, psychiatry and psychology. It provides a new means for the treatment of depression, lower back pain, multiple sclerosis and other diseases. There are two potential mechanisms: physiological and psychological. In the future, exercise effects, adverse effects and exercise prescriptions of TC should be explored with large samples and high-quality randomized controlled trials.
COVID-19 Outbreak: Understanding Moral-Distress Experiences Faced by Healthcare Workers in British Columbia, Canada
Authors: Alonso-Prieto Esther , Longstaff Holly , Black Agnes , Virani Alice K.
Published: August 2022

Pandemic-management plans shift the care model from patient-centred to public-centred and increase the risk of healthcare workers (HCWs) experiencing moral distress (MD). This study aimed to understand HCWs’ MD experiences during the COVID-19 pandemic and to identify HCWs’ preferred coping strategies. Based on a qualitative research methodology, three surveys were distributed at different stages of the pandemic response in British Columbia (BC), Canada. The thematic analysis of the data revealed common MD themes: concerns about ability to serve patients and about the risks intrinsic to the pandemic. Additionally, it revealed that COVID-19 fatigue and collateral impact of COVID-19 were important ethical challenges faced by the HCWs who completed the surveys. These experiences caused stress, anxiety, increased/decreased empathy, sleep disturbances, and feelings of helplessness. Respondents identified self-care and support provided by colleagues, family members, or friends as their main MD coping mechanisms. To a lesser extent, they also used formal sources of support provided by their employer and identified additional strategies they would like their employers to implement (e.g., improved access to mental health and wellness resources). These results may help inform pandemic policies for the future.
Managing Directors’ Perspectives on Digital Maturity in German Hospitals—A Multi-Point Online-Based Survey Study
Authors: Burmann Anja , Fischer Burkhard , Brinkkötter Nico , Meister Sven
Published: August 2022

Background: The digitalization and integration of data are increasingly relevant for hospitals. Several methods exist to assess and structurally develop digital maturity. However, it is notable that German hospitals lag behind the European average with respect to digitalization. Objective: We hypothesized that: (a) the perspective of hospital managing directors regarding the state of digitalization in German hospitals plays an important role in the investigation of barriers, and (b) the Hospital Future Act in 2020 may help to surmount those barriers. Methods: Aligned with the Checklist for Reporting Results of Internet E-Surveys (CHERRIES), two online surveys were conducted, one in 2019 and one in 2021. Results: The first study covered 184/344 hospitals and the second, 83/344. The responsibility for deciding on the implementation of digitalization lay with the management (115/184; 62.5%). About 54.9% (101/184) of the managing directors desired digitally supported workflows, together with employees or users. In total, 74.7% (62/83) of hospital managing directors expressed an increase in digitization compared to 2019, with a percentage increase of 25.4% (SD 14.41). In some cases, we analyzed the data using an ANOVA, chi-squared test and Pearson’s correlation, but there was no significant relation identified among the variables. Conclusions: This online-based survey study demonstrated that the development of a digitalization strategy is still strongly tied to or dominated by the attitude of the management. One could assume a lack of acceptance among employees, which should be surveyed in future research. The Hospital Future Act, as well as the COVID-19 pandemic, has positively influenced the digital maturity of hospitals.
Manipulation under Anesthesia versus Non-Surgical Treatment for Patients with Frozen Shoulder Contracture Syndrome: A Systematic Review
Authors: Salomon Mattia , Pastore Chiara , Maselli Filippo , Di Bari Mauro , Pellegrino Raffaello , Brindisino Fabrizio
Published: August 2022

Purpose: To investigate the efficacy of manipulation under anesthesia (MUA) compared to other non-surgical therapeutic strategies for patients with frozen shoulder contracture syndrome (FSCS). Methods: A systematic review of literature was conducted. A literature search was performed in MEDLINE, EMBASE, PEDro, Cochrane Central Library and Scopus. Only randomized controlled trials were included and assessed for critical appraisal through the Cochrane Collaborations tools. Results: Five randomized controlled trials were included. The overall risk of bias (RoB) was high in 4 out of 5 of the included studies. MUA was found to be not superior in terms of reduction of pain and improvement of function when compared to cortisone injections with hydrodilatation (mean regression coefficient MUA −2.77 vs. injection −2.75; 95% CI (−1.11 to 1.15)) and home exercise (mean difference 95% CI: 0.2 (−0.64 to 1.02)) in the short term (3 months), and cortisone injections with hydrodilatation (mean regression coefficient MUA 3.13 vs. injection 3.23; 95% CI (−0.90 to 1.11)) in the long term (>6 months). Moreover, if compared to structured physiotherapy, MUA highlighted a higher Oxford Shoulder Score at final 1-year follow up (mean difference 95% CI: 1.05 (−1.28 to 3.39); p = 0.38). Similar results were obtained for disability, with statistically no significant long-term (>12 months) differences between MUA and home exercise (mean difference 95% CI: 0 (−3.2 to 3.2)) or structured physiotherapy (mean difference 95% CI: −0.50 (−5.70 to 4.70); p = 0.85)). Only two trials reported adverse events. Conclusions: This review suggested that limited and inconsistent evidence currently exists on the efficacy of MUA compared to other non-surgical strategies in the management of patients with FSCS. Future research should focus on clinical trials with higher methodological quality.
The Association between Types of COVID-19 Information Source and the Avoidance of Child Health Checkups in Japan: Findings from the JACSIS 2021 Study
Authors: Ojio Masafumi , Maeda Yuto , Tabuchi Takahiro , Fujiwara Takeo
Published: August 2022

The coronavirus disease 2019 (COVID-19) pandemic can affect children’s well-being through mothers’ avoidance of health checkups for children due to media portrayal of the disease. This study investigated the association between the type of information source for COVID-19 received by mothers and the avoidance of their children’s health checkups. The study was an online-based survey, and the participants comprised 5667 postpartum women with children aged under 2 years during the study period. We analyzed the analytic sample and three groups of women with children aged 0–3 months, 4–6 months, and 6 months or older according to the timing of children’s health checkups in Japan. Among the participants, 382 women (6.7%) avoided their children’s health checkups. Multivariate logistic regression analysis revealed that mothers with children over 6 months who used magazines as an information source about COVID-19 tended to avoid their children’s health checkups (adjusted odds ratio (aOR): 3.19; 95% confidence interval (CI): 1.68–6.05) compared with those who did not. In contrast, those using public websites were less likely to avoid their children’s health checkups (aOR 0.58, 95% CI 0.43–0.77). This study showed that specific types of information source on COVID-19 could have varying effects on mothers’ decisions about their children’s health checkups.
The Role of Mindfulness in Mitigating the Detrimental Effects of Harsh Parenting among Chinese Adolescents: Testing a Moderated Mediation Model in a Three-Wave Study
Authors: Sun Wenyan , Guo Tengfei , Spruyt Karen , Liu Zhijun
Published: August 2022

Based on the conservation of resources theory, this study aimed to investigate the mediating role of depressive symptoms and the moderating role of mindfulness in the association between harsh parenting and adolescent suicidal ideation in the Chinese cultural context. Using a three-wave (i.e., three months apart) data collection among 371 Chinese adolescents, this study found that depressive symptoms mediated the relationship between harsh parenting and adolescent suicidal ideation. Moreover, adolescent mindfulness mitigated the effects of harsh parenting on suicidal ideation, as well as the indirect effect of harsh parenting on suicidal ideation via depressive symptoms. The theoretical and practical implications are discussed.
Collaborative Reverse Logistics Network for Infectious Medical Waste Management during the COVID-19 Outbreak
Authors: Luo Xuan , Liao Wenzhu
Published: August 2022

The development of COVID-19 in China has gradually become normalized; thus, the prevention and control of the pandemic has encountered new problems: the amount of infectious medical waste (IMW) has increased sharply; the location of outbreaks are highly unpredictable; and the pandemic occurs everywhere. Thus, it is vital to design an effective IMW reverse logistics network to cope with these problems. This paper firstly introduces mobile processing centers (MPCs) into an IMW reverse logistics network for resource-saving, quick response, and the sufficient capacity of processing centers. Then, a multi-participant-based (public central hospitals, disposal institutions, the logistics providers, and the government) collaborative location and a routing optimization model for IMW reverse logistics are built from an economic, environmental perspective. An augmented ε-constraint method is developed to solve this proposed model. Through a case study in Chongqing, it is found that for uncertain outbreak situations, fixed processing centers (FPCs) and MPCs can form better disposal strategies. MPC can expand the processing capacity flexibly in response to the sudden increase in IMW. The results demonstrate good performance in reduction in cost and infection risk, which could greatly support the decision making of IMW management for the government in the pandemic prevention and control.
Exploring the Impact of Floating Population with Different Household Registration on Theft
Authors: Xu Chong , Chen Xi , Chen Jianguo , Chen Debao
Published: August 2022

The floating population is frequently treated as a homogeneous whole to explore its impact on crime in numerous crime studies in China. However, there are different compositions within the floating population and significant differences in the effects on crime. In this study, the floating population was divided into three types based on household registration (i.e., Hukou): the floating population from other districts in the same city (FPFOD), the floating population from other cities in the same province (FPFOC) and the floating population from other provinces (FPFOP). The Moran index was used to analyze their spatial distribution patterns and aggregation, respectively, and several negative binomial regression models were constructed to explore the influence of different types of floating populations on theft. The results show that the three types of floating populations are mainly distributed in different urban areas, implying differences in their impact on theft. Among them, the proportion of the FPFOD shows insignificant negative correlation on theft, while the proportion of the FPFOC and the FPFOP present a significant positive correlation. Meanwhile, the proportion of the FPFOP creates a stronger effect on theft than the proportion of entire floating population. Overall, the model performs best when variables of the proportion of the FPFOC and the FPFOP are included. The research conclusions can provide a meaningful reference for precisely measuring the floating population in crime research.
Recent Research Progress of Ionic Liquid Dissolving Silks for Biomedicine and Tissue Engineering Applications
Authors: Heng Hang , Deng Qianqian , Yang Yipeng , Wang Fang
Published: August 2022

Ionic liquids (ILs) show a bright application prospect in the field of biomedicine and energy materials due to their unique recyclable, modifiability, structure of cation and anion adjustability, as well as excellent physical and chemical properties. Dissolving silk fibroin (SF), from different species silkworm cocoons, with ILs is considered an effective new way to obtain biomaterials with highly enhanced/tailored properties, which can significantly overcome the shortcomings of traditional preparation methods, such as the cumbersome, time-consuming and the organic toxicity caused by manufacture. In this paper, the basic structure and properties of SF and the preparation methods of traditional regenerated SF solution are first introduced. Then, the dissolving mechanism and main influencing factors of ILs for SF are expounded, and the fabrication methods, material structure and properties of SF blending with natural biological protein, inorganic matter, synthetic polymer, carbon nanotube and graphene oxide in the ILs solution system are introduced. Additionally, our work summarizes the biomedicine and tissue engineering applications of silk-based materials dissolved through various ILs. Finally, according to the deficiency of ILs for dissolving SF at a high melting point and expensive cost, their further study and future development trend are prospected.
Heritable Epigenomic Modifications Influence Stress Resilience and Rapid Adaptations in the Brown Planthopper (Nilaparvata lugens)
Authors: Gupta Ayushi , Nair Suresh
Published: August 2022

DNA methylation in insects is integral to cellular differentiation, development, gene regulation, genome integrity, and phenotypic plasticity. However, its evolutionary potential and involvement in facilitating rapid adaptations in insects are enigmatic. Moreover, our understanding of these mechanisms is limited to a few insect species, of which none are pests of crops. Hence, we studied methylation patterns in the brown planthopper (BPH), a major rice pest, under pesticide and nutritional stress, across its life stages. Moreover, as the inheritance of epigenetic changes is fundamentally essential for acclimation, adaptability, and evolution, we determined the heritability and persistence of stress-induced methylation marks in BPH across generations. Our results revealed that DNA methylation pattern(s) in BPH varies/vary with environmental cues and is/are insect life-stage specific. Further, our findings provide novel insights into the heritability of stress-induced methylation marks in BPH. However, it was observed that, though heritable, these marks eventually fade in the absence of the stressors, thereby suggesting the existence of fitness cost(s) associated with the maintenance of the stressed epigenotype. Furthermore, we demonstrate how 5-azacytidine-mediated disruption of BPH methylome influences expression levels of stress-responsive genes and, thereby, highlight demethylation/methylation as a phenomenon underlying stress resilience of BPH.
Cobalt Ferrite Magnetic Nanoparticles for Tracing Mesenchymal Stem Cells in Tissue: A Preliminary Study
Authors: Večerić-Haler Željka , Kojc Nika , Wechtersbach Karmen , Perše Martina , Erman Andreja
Published: August 2022

Therapy with mesenchymal stem cells (MSCs) is promising in many diseases. Evaluation of their efficacy depends on adequate follow-up of MSCs after transplantation. Several studies have shown that MSCs can be labeled and subsequently visualized with magnetic nanoparticles (NPs). We investigated the homing of MSCs labeled with magnetic cobalt ferrite NPs in experimentally induced acute kidney injury in mice. To explore the homing of MSCs after systemic infusion into mice, we developed a pre-infusion strategy for optimal tracing and identification of MSCs with polyacrylic acid-coated cobalt ferrite (CoFe2O4) NPs by light and transmission electron microscopy (TEM) in various organs of mice with cisplatin-induced acute kidney injury and control mice. By correlative microscopy, we detected MSCs labeled with NPs in the lungs, spleen, kidney, and intestine of cisplatin-treated mice and in the lungs and spleen of control mice. Our results confirm that labeling MSCs with metal NPs did not affect the ultrastructure of MSCs and their ability to settle in various organs. This study demonstrates the usefulness of cobalt ferrite NPs in ex vivo visualization of MSCs and offers correlative microscopy as a useful method in routine histopathology laboratories for tracing MSCs in paraffin-embedded tissue.
Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin Signalling and Migration
Authors: Azubuike Udochi F. , Newton Claire L. , van den Bout Iman
Published: August 2022

Kisspeptin is an anti-metastatic mediator in many cancer types, acting through its receptor, KISS1R. However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic roles have been ascribed to it. In KISS1R overexpressing triple-negative breast cancer (TNBC) cells, stimulation has been associated with increased invasion and MMP-9 expression, leading to the suggestion that hormone receptor status determines the metastatic effects of kisspeptin. To assess the veracity of this claim, we compared endogenous KISS1R signalling and physiological output in the hormone receptor-negative MDA-MB-231 and BT-20 cell lines after KP-10 (shortest active kisspeptin peptide) stimulation. MDA-MB-231 cells are metastatic when implanted in mice while BT-20 are not and remain epithelial-like. We show that both cell lines express KISS1R mRNA and respond to KP-10 by elevating calcium mobilisation. However, KP-10 stimulation induced migration of MDA-MB-231, but not BT-20 cells, in a calcium-dependent manner. Moreover, only BT-20 cells responded to KP-10 by increasing ERK phosphorylation in a β-arrestin-dependent manner. Interestingly, both cell lines displayed different complements of β-arrestin 1 and 2 expression. Overall, our data shows that, in TNBC, it is not universally true that kisspeptin/KISS1R stimulate migration or pro-metastatic behaviour, as divergent responses were observed in the two TNBC lines tested. Whether this divergence is related to the observed differences in β-arrestin complements warrants further investigation and may enable further stratification of the ability of kisspeptin to influence breast tumour behaviour.
Current Knowledge in Skin Metabolomics: Updates from Literature Review
Authors: Paganelli Alessia , Righi Valeria , Tarentini Elisabetta , Magnoni Cristina
Published: August 2022

Metabolomic profiling is an emerging field consisting of the measurement of metabolites in a biological system. Since metabolites can vary in relation to different stimuli, specific metabolic patterns can be closely related to a pathological process. In the dermatological setting, skin metabolomics can provide useful biomarkers for the diagnosis, prognosis, and therapy of cutaneous disorders. The main goal of the present review is to present a comprehensive overview of the published studies in skin metabolomics. A search for journal articles focused on skin metabolomics was conducted on the MEDLINE, EMBASE, Cochrane, and Scopus electronic databases. Only research articles with electronically available English full text were taken into consideration. Studies specifically focused on cutaneous microbiomes were also excluded from the present search. A total of 97 papers matched all the research criteria and were therefore considered for the present work. Most of the publications were focused on inflammatory dermatoses and immune-mediated cutaneous disorders. Skin oncology also turned out to be a relevant field in metabolomic research. Only a few papers were focused on infectious diseases and rarer genetic disorders. All the major metabolomic alterations published so far in the dermatological setting are described extensively in this review.
Phylogenetic-Related Divergence in Perceiving Suitable Host Plants among Five Spider Mites Species (Acari: Tetranychidae)
Authors: Hu Qi-Qi , Yu Xin-Yue , Xue Xiao-Feng , Hong Xiao-Yue , Zhang Jian-Ping , Sun Jing-Tao
Published: August 2022

Spider mites belonging to the genus Tetranychus infest many important agricultural crops in both fields and greenhouses worldwide and are diversified in their host plant range. How spider mites perceive their suitable host plants remains not completely clear. Here, through two-host-choice designs (bean vs. tomato, and bean vs. eggplant), we tested the efficacies of the olfactory and gustatory systems of five spider mite species (T. urticae, T. truncatus, T. pueraricola, T. piercei, and T. evansi), which differ in host plant range in sensing their suitable host plant, by Y-tube olfactometer and two-choice disc experiments. We found that spider mites cannot locate their suitable host plants by volatile odours from a long distance, but they can use olfactory sensation in combination with gustatory sensation to select suitable host plants at a short distance. Highly polyphagous species displayed strong sensitivity in sensing suitable host plants rather than the lowered sensitivity we expected. Intriguingly, our principal component analyses (PCAs) showed that the similarity among five spider mite species in the performance of perceiving suitable host plants was highly correlated with their relative phylogenetic relationships, suggesting a close relationship between the chemosensing system and the speciation of spider mites. Our results highlight the necessity of further work on the chemosensing system in relation to host plant range and speciation of spider mites.
Hemodynamic Performance of Two Current-Generation Transcatheter Heart Valve Prostheses in Severely Calcified Aortic Valve Stenosis
Authors: Potratz Max , Mohemed Kawa , Omran Hazem , Gortamashvili Lasha , Friedrichs Kai Peter , Scholtz Werner , Scholtz Smita , Rudolph Volker , Piper Cornelia , Gilis-Januszewski Tomasz , Schramm René , Furukawa Nobuyuki , Gummert Jan , Bleiziffer Sabine , Rudolph Tanja Katharina
Published: August 2022

Background: Treatment of severely calcified aortic valve stenosis is associated with a higher rate of paravalvular leakage (PVL) and permanent pacemaker implantation (PPI). We hypothesized that the self-expanding transcatheter heart valve (THV) prostheses Evolut Pro (EPro) is comparable to the balloon-expandable Sapien 3 (S3) regarding hemodynamics, PPI, and clinical outcome in these patients. Methods: From 2014 to 2019, all patients with very severe calcification of the aortic valve who received an EPro or an S3 THV were included. Propensity score matching was utilized to create two groups of 170 patients. Results: At discharge, there was significant difference in transvalvular gradients (EPro vs. S3) (dPmean 8.1 vs. 11.1 mmHg, p ≤ 0.001) and indexed effective orifice area (EOAi) (1.1 vs. 0.9, p ≤ 0.001), as well as predicted EOAi (1 vs. 0.9, p ≤ 0.001). Moderate patient prosthesis mismatch (PPM) was significantly lower in the EPro group (17.7% vs. 38%, p ≤ 0.001), as well as severe PPM (2.9% vs. 8.8%, p = 0.03). PPI and the PVL rate as well as stroke, bleeding, vascular complication, and 30-day mortality were comparable. Conclusions: In patients with severely calcified aortic valves, both THVs performed similarly in terms of 30-day mortality, PPI rate, and PVL occurrence. However, patient prothesis mismatch was observed more often in the S3 group, which might be due to the intra-annular design.
A Machine Learning Model for Predicting Hospitalization in Patients with Respiratory Symptoms during the COVID-19 Pandemic
Authors: De Freitas Victor Muniz , Chiloff Daniela Mendes , Bosso Giulia Gabriella , Teixeira Janaina Oliveira Pires , Hernandes Isabele Cristina de Godói , Padilha Maira do Patrocínio , Moura Giovanna Corrêa , De Andrade Luis Gustavo Modelli , Mancuso Frederico , Finamor Francisco Estivallet , Serodio Aluísio Marçal de Barros , Arakaki Jaquelina Sonoe Ota , Sartori Marair Gracio Ferreira , Ferreira Paulo Roberto Abrão , Rangel Érika Bevilaqua
Published: August 2022

A machine learning approach is a useful tool for risk-stratifying patients with respiratory symptoms during the COVID-19 pandemic, as it is still evolving. We aimed to verify the predictive capacity of a gradient boosting decision trees (XGboost) algorithm to select the most important predictors including clinical and demographic parameters in patients who sought medical support due to respiratory signs and symptoms (RAPID RISK COVID-19). A total of 7336 patients were enrolled in the study, including 6596 patients that did not require hospitalization and 740 that required hospitalization. We identified that patients with respiratory signs and symptoms, in particular, lower oxyhemoglobin saturation by pulse oximetry (SpO2) and higher respiratory rate, fever, higher heart rate, and lower levels of blood pressure, associated with age, male sex, and the underlying conditions of diabetes mellitus and hypertension, required hospitalization more often. The predictive model yielded a ROC curve with an area under the curve (AUC) of 0.9181 (95% CI, 0.9001 to 0.9361). In conclusion, our model had a high discriminatory value which enabled the identification of a clinical and demographic profile predictive, preventive, and personalized of COVID-19 severity symptoms.