bluuebunny/crossref_metadata_2025 huggingface dataset:
An Empirical Study of Visitors’ Experience at Kuching Orchid Garden with Mobile Guide Application
Authors: Othman Mohd Kamal , Idris Khairul Izham , Aman Shaziti , Talwar Prashanth
Published: June 2018

This empirical study was conducted to measure visitors’ experiences with a mobile guide application at Kuching Orchid Garden (KOG). A between-group experimental design with 114 participants was conducted to test three groups;(1)a group using the mobile guide application as an information aid,(2)a control group (with no information aid), and(3)a group using pamphlets to explore the KOG. The Museum Experience Scale (MES) was used to evaluate visitors’ experience for all participants, whilst the Multimedia Guide Scale (MMGS) was used to evaluate the visitors’ experience with the mobile guide group. The most notable result from the Museum Experience Scale (MES) showed an impact on the visitors in terms of knowledge and learning when using the mobile guide application. However, the study found that enhancing visitors experience goes beyond simply providing interactive technologies in public settings to aid with information delivery. A limitation was providing relevant information in a timely and seamless manner due to inaccuracies of mapping between physical and digital environments. Future works should consider beacons and other Bluetooth low energy (BLE) technology to address the issues with location based devices. It is also important to highlight that the use of one’s own device had a significant impact on learnability and control of the device, thus suggesting that the BYOD concept should be widely used in informal educational settings implementing mobile guide applications. The use of MES and MMGS informs future researches with an understanding of the different dimensions of visitors’ experiences with mobile guide technology in public spaces to inform mobile application development that may further boost visitors’ engagement, emotional connection, and meaningful experience.
A Two-Level Sound Classification Platform for Environmental Monitoring
Authors: Mitilineos Stelios A. , Potirakis Stelios M. , Tatlas Nicolas-Alexander , Rangoussi Maria
Published: June 2018

STORM is an ongoing European research project that aims at developing an integrated platform for monitoring, protecting, and managing cultural heritage sites through technical and organizational innovation. Part of the scheduled preventive actions for the protection of cultural heritage is the development of wireless acoustic sensor networks (WASNs) that will be used for assessing the impact of human-generated activities as well as for monitoring potentially hazardous environmental phenomena. Collected sound samples will be forwarded to a central server where they will be automatically classified in a hierarchical manner; anthropogenic and environmental activity will be monitored, and stakeholders will be alarmed in the case of potential malevolent behavior or natural phenomena like excess rainfall, fire, gale, high tides, and waves. Herein, we present an integrated platform that includes sound sample denoising using wavelets, feature extraction from sound samples, Gaussian mixture modeling of these features, and a powerful two-layer neural network for automatic classification. We contribute to previous work by extending the proposed classification platform to perform low-level classification too, i.e., classify sounds to further subclasses that include airplane, car, and pistol sounds for the anthropogenic sound class; bird, dog, and snake sounds for the biophysical sound class; and fire, waterfall, and gale for the geophysical sound class. Classification results exhibit outstanding classification accuracy in both high-level and low-level classification thus demonstrating the feasibility of the proposed approach.
Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice
Authors: Taddio Marco F. , Mu Linjing , Keller Claudia , Schibli Roger , Krämer Stefanie D.
Published: June 2018

Physiologically based pharmacokinetic modelling (PBPK) is a powerful tool to predict in vivo pharmacokinetics based on physiological parameters and data from in vivo studies and in vitro assays. In vivo PBPK modelling in laboratory animals by noninvasive imaging could help to improve the in vivo-in vivo translation towards human pharmacokinetics modelling. We evaluated the feasibility of PBPK modelling with PET data from mice. We used data from two of our PET tracers under development, [11C]AM7 and [11C]MT107. PET images suggested hepatobiliary excretion which was reduced after cyclosporine administration. We fitted the time-activity curves of blood, liver, gallbladder/intestine, kidney, and peripheral tissue to a compartment model and compared the resulting pharmacokinetic parameters under control conditions ([11C]AM7 n=2; [11C]MT107, n=4) and after administration of cyclosporine ([11C]MT107, n=4). The modelling revealed a significant reduction in [11C]MT107 hepatobiliary clearance from 35.2±10.9 to 17.1±5.6 μl/min after cyclosporine administration. The excretion profile of [11C]MT107 was shifted from predominantly hepatobiliary (CLH/CLR = 3.8±3.0) to equal hepatobiliary and renal clearance (CLH/CLR = 0.9±0.2). Our results show the potential of PBPK modelling for characterizing the in vivo effects of transporter inhibition on whole-body and organ-specific pharmacokinetics.
Minimally Invasive Plate Osteosynthesis for Proximal Humerus Fractures: A Retrospective Study Describing Principles and Advantages of the Technique
Authors: Alberio Riccardo Luigi , Del Re Matteo , Grassi Federico Alberto
Published: June 2018

Background. The aim of this study was to evaluate the clinical and radiographic results after minimally invasive plate osteosynthesis (MIPO) for proximal humerus fractures. Potential advantages of this approach include the easier exposure of the greater tuberosity and the limited surgical dissection around the fracture site. Materials and Methods. From October 2011 to March 2016, thirty-nine patients (32 women, 7 men) with a mean age of 64.9 years (range: 48–80) were surgically treated with the MIPO technique for proximal humeral fractures. According to Neer classification, there were 12 two-part, 24 three-part, and 2 four-part fractures and 1 two-part fracture-dislocation; the AO/OTA system was also used to categorize the fractures. The Constant-Murley (CMS) and the Oxford Shoulder (OSS) Scores were used to evaluate shoulder function. Results. Thirty-four patients were available for clinical and radiographic evaluation at a mean follow-up of 31.8 months (range: 12–54 months). All fractures healed and no postoperative complications occurred. Full recovery of pretrauma activities was reported by 27 patients, while 7 patients presented mild functional limitations. The mean absolute CMS was 75.2 (range: 55–95), the mean normalized CMS was 90.5 (range: 69–107), and the mean OSS was 43.7 (range: 31–48). The only statistically significant correlation was found between the female gender and lower absolute CMS and OSS. Radiographic evaluation revealed varus malunion in 4 cases and valgus malunion in 1 case, while incomplete greater tuberosity reduction was detected in 4 cases. All malunions were related to inadequate reduction at time of surgery and not to secondary displacement. Conclusions. MIPO for proximal humeral fractures is an effective and safe surgical procedure. The limited tissue dissection allows minimizing the incidence of nonunion, avascular necrosis, and infection. The technique is not easy, requires experience to achieve mastery, and should be reserved for selected fracture patterns. In our experience, the main advantage of this approach consists in the direct access to the greater tuberosity, thus facilitating its anatomic reduction and fixation.
Synthesis, Morphology, and Hydrogen Absorption Properties of TiVMn and TiCrMn Nanoalloys with a FCC Structure
Authors: Li Bo , Li Jianding , Shao Huaiyu , Li Wei , Lin Huaijun
Published: June 2018

TiVMn and TiCrMn alloys are promising hydrogen storage materials for onboard application due to their high hydrogen absorption content. However, the traditional synthesis method of melting and continuous necessary heat treatment and activation process are energy- and time-consuming. There is rarely any report on kinetics improvement and nanoprocessing in TiVMn- and TiCrMn-based alloys. Here, through ball milling with carbon black as additive, we synthesized face-centered cubic (FCC) structure TiVMn- and TiCrMn-based nanoalloys with mean particle sizes of around a few to tens of μm and with the crystallite size just 10 to 13 nm. Differential scanning calorimetry (DSC) measurements under hydrogen atmosphere of the two obtained TiVMn and TiCrMn nanoalloys show much enhancement on the hydrogen absorption performance. The mechanism of the property improvement and the difference in the two samples were discussed from microstructure and morphology aspects. The study here demonstrates a new potential methodology for development of next-generation hydrogen absorption materials.
Prevalence and Risk Factors Associated with Injurious Falls among Community-Dwelling Older Adults in Indonesia
Authors: Pengpid Supa , Peltzer Karl
Published: June 2018

Objective. To assess the prevalence and health correlates of fall-related injury in a national population-based community-dwelling sample of older Indonesians. Methods. Participants were 6698 older adults, 50 years and older (median age 58.0 years, IQR=11.0, and age range of 50–101 years), who took part in in the Indonesia Family Life Survey (IFLS-5) in 2014-15. They provided information about sociodemographic, various health variables, including a falling down and received treatment history in the last two years. Results. Overall, 12.8% had one or more fall-related injuries in the past two years, 14.0% among women and 11.5% among men, 7.6% had a single fall, and 5.2% multiple fall-related injuries in the past two years. In multivariable logistic regression models, having two or more chronic conditions, urinary problems, and functional disability was independently associated with multiple fall-related injuries in the past two years in both sexes. Sex-specific risk factors were former tobacco use, having or having had a cataract, sleep disturbance, and sleep impairment in men and poorer economic background, depression symptoms, and low cognitive functioning in women. Conclusion. A significant proportion of older adults in Indonesia have fall-related injury. Several homogenous between the sexes and sex-specific risk factors for fall-related injury were identified that can help in designing fall-prevention strategies.
Vision System-Based Design and Assessment of a Novel Shoulder Joint Mechanism for an Enhanced Workspace Upper Limb Exoskeleton
Authors: Piña-Martínez Eduardo , Roberts Ricardo , Leal-Merlo Salvador , Rodriguez-Leal Ernesto
Published: June 2018

Exoskeletons arise as the common ground between robotics and biomechanics, where rehabilitation is the main field in which these two disciplines find cohesion. One of the most relevant challenges in upper limb exoskeleton design relies in the high complexity of the human shoulder, where current devices implement elaborate systems only to emulate the drifting center of rotation of the shoulder joint. This paper proposes the use of 3D scanning vision technologies to ease the design process and its implementation on a variety of subjects, while a motion tracking system based on vision technologies is applied to assess the exoskeleton reachable workspace compared with an asymptomatic subject. Furthermore, the anatomic fitting index is proposed, which compares the anatomic workspace of the user with the exoskeleton workspace and provides insight into its features. This work proposes an exoskeleton architecture that considers the clavicle motion over the coronal plane whose workspace is determined by substituting the direct kinematics model with the dimensional parameters of the user. Simulations and numerical examples are used to validate the analytical results and to conciliate the experimental results provided by the vision tracking system.
Diarrhea Prevalence and Sociodemographic Factors among Under-Five Children in Rural Areas of North Gondar Zone, Northwest Ethiopia
Authors: Getachew Atalay , Guadu Tadesse , Tadie Alebachew , Gizaw Zemichael , Gebrehiwot Mulat , Cherkos Daniel Haile , Menberu Martha Alemayehu , Gebrecherkos Teklay
Published: June 2018

Background. Diarrheal disease remains one of the principal causes of morbidity and mortality in infants and children in developing countries, including Ethiopia. Risk factors for diarrhea vary by settings and have important implications for developing intervention strategies to reduce the burden of the disease. Thus, the aim of this study was to assess diarrhea prevalence and sociodemographic factors among under-five children in rural areas of North Gondar Zone. Methods. A community-based cross-sectional study was conducted from April to June 2016 among 736 randomly selected households with one child under five years old. A structured questionnaire was used for collecting information on sociodemographic characteristics and diarrheal occurrence. Data was analyzed using SPSS version 20. The bivariate and multivariable logistic regression analysis were used to determine the association between risk factors and diarrheal occurrence, and a p value < 0.05 was taken as statistically significant. Results. A total of 736 under-five children and their respondents were enrolled during the study period. Almost all respondents were biological mothers 96.4% (709/736), married 94.2% (693/736), and house wives 86% (632/736). The overall prevalence of diarrheal disease among under-five children was 22.1% (163/743). Of these, children with age group of less than one year old, 7.7 % (57/736), were commonly infected with diarrheal diseases. Children less than or equal to one year [AOR=1.82, 95% CI= (1.39, 4.63)], guardians [AOR=4.37, 95% CI= (1.73, 11.1)], and children with no breast feeding practice [AOR=3.13, 95% CI= (1.62, 6.03)] were the major risk factors for the occurrence of diarrhea. Conclusion. Childhood diarrhea remains an important health concern in the study area. Occurrence of diarrhea was statistically associated with child age less than or equal to one year, educational status of mother/guardians, and breast feeding. To minimize the magnitude childhood diarrhea, various designing and implementing strategies, such as health education, child care, breast feeding, and weaning practice, integrated with the existing national health extension are quite essential.
The Bioactive Substance Secreted by MSC Retards Mouse Aortic Vascular Smooth Muscle Cells Calcification
Authors: Wang Shuangshuang , Tong Maoqing , Hu Siwang , Chen Xiaomin
Published: June 2018

Background. Vascular calcification, which is associated with low-level chronic inflammation, is a complication that occurs during aging, atherosclerosis, chronic kidney disease, diabetes mellitus, and hyperlipaemia. In this study, we used conditioned media from mesenchymal stem cells (MSC-CM), a source of autologous cytokines, to test the hypothesis that MSC-CM inhibits vascular smooth muscle cell (VSMC) calcification by suppressing inflammation and apoptosis. Methods. VSMCs were treated with β-glycerophosphate (β-GP) to induce calcification and MSC-CM was used as a treatment. Calcium deposition was evaluated using alizarin red and von Kossa staining after a 7-day induction period. Intracellular calcium contents were measured via the o-cresolphthalein complexone method, and alkaline phosphatase (ALP) activity was determined using the para-nitrophenyl phosphate method. The expressions of specific-osteogenic markers, inflammatory cytokines, and apoptosis-associated genes/proteins were examined by real-time polymerase chain reaction or western blotting. Results. MSC-CM inhibited β-GP-induced calcium deposition in VSMCs and decreased intracellular calcium content and ALP activity. Additionally, MSC-CM suppressed the β-GP-induced increases in BMP2, Msx2, Runx2, and osteocalcin expression. Additionally, MSC-CM decreased the expression of TNF-α, IL-1β, and IL-6 in VSMC. MSC-CM also partly blocked β-GP-induced VSMC apoptosis, which was associated with an increase in the Bcl-2/Bax expression ratio and a decrease in caspase-3 expression. Conclusion. Our study results suggest that MSC-CM can inhibit VSMC calcification. This suggests a potential novel clinical application for MSCs in the treatment of vascular calcification and associated diseases.
Basosquamous Carcinoma: A Single Centre Clinicopathological Evaluation and Proposal of an Evidence-Based Protocol
Authors: Oldbury Jordan W. , Wain Richard A. J. , Abas Sameera , Dobson Christopher M. , Iyer Srinivasan S.
Published: June 2018

Basosquamous carcinoma (BSC) is an uncommon skin malignancy with significant invasive and metastatic potential. There are currently no clear management guidelines. This study evaluates the management and outcomes of patients diagnosed with BSC over a 7-year period. We present an evidence-based unit protocol for the management of BSC. All patients treated for BSC between 2009 and 2015 were reviewed. Data collected included patient demographics, tumour-specific information, management strategy, presence of recurrence or metastasis, and details of follow-up. 74 patients were identified, making this one of the largest cohorts of BSC patients reported. Mean age at diagnosis was 75.4 years, with a male:female ratio of 1.6:1. The most common tumour site was the head and neck (n=43, 58.1%). All tumours were graded at pT1 (n=51) or pT2 (n=23). Inadequate excision occurred in 17 patients (23%). Mean excision margins were >4mm peripherally and deep. Inadequately excised BSCs were further treated with wide local excision (n=6) or radiotherapy (n=5), or both (n=1). There were no cases of local recurrence or metastatic disease. This study demonstrates a cohort of patients with BSCs that appear less aggressive than previously reported. Current management with surgical excision appears to produce adequate results. However, an evidence-based guideline is still lacking.
Factors Associated with Successful Trial of Labor after Cesarean Section: A Retrospective Cohort Study
Authors: Thapsamuthdechakorn Aram , Sekararithi Ratanaporn , Tongsong Theera
Published: June 2018

Objective. To determine the effectiveness of trial of labor after cesarean section (TOLAC) and the factors associated with a successful TOLAC. Materials and Methods. A retrospective cohort study was conducted on consecutive singleton pregnancies with a previous single low-transverse cesarean section planned for TOLAC at a tertiary teaching hospital. The potential risk factors of a successful TOLAC were compared with those associated with a failed TOLAC. A simple audit system used in the first two years was also taken into account in the analysis as a potential factor for success. Results. During the study period, 2,493 women were eligible for TOLAC and 704 of them were scheduled for TOLAC, but finally 592 underwent TOLAC. Among them, 355 (60%) had a successful vaginal birth and 237 (40%) had a failed TOLAC. The independent factors associated with the success rate included the audit system, prior vaginal birth, low maternal BMI, and lower birth weight or gestational age, whereas induction of labor and recurring indications in previous pregnancy significantly increased the risk of having a failed TOLAC. Strikingly, the strongest predictor of a successful TOLAC was the audit system with OR of 6.4 (95%CI: 3.9-10.44), followed by a history of vaginal birth in previous pregnancies (OR: 3.2; 95%CI: 1.87-5.36). Conclusion. The simple audit system had the greatest impact on the success rate of TOLAC, instead of the less powerful obstetrical factors as reported in previous reports. The audit system is the only potential factor that could be strengthened to improve the success rate.
A Heuristic Approach for Optimal Planning and Operation of Distribution Systems
Authors: Alzaidi Khalid Mohammed Saffer , Bayat Oguz , Uçan Osman N.
Published: June 2018

The efficient planning and operation of power distribution systems are becoming increasingly significant with the integration of renewable energy options into power distribution networks. Keeping voltage magnitudes within permissible ranges is vital; hence, control devices, such as tap changers, voltage regulators, and capacitors, are used in power distribution systems. This study presents an optimization model that is based on three heuristic approaches, namely, particle swarm optimization, imperialist competitive algorithm, and moth flame optimization, for solving the voltage deviation problem. Two different load profiles are used to test the three modified algorithms on IEEE 123- and IEEE 13-bus test systems. The proposed optimization model uses three different cases: Case 1, changing the tap positions of the regulators; Case 2, changing the capacitor sizes; and Case 3, integrating Cases 1 and 2 and changing the locations of the capacitors. The numerical results of the optimization model using the three heuristic algorithms are given for the two specified load profiles.
Parotid Oncocytoma as a Manifestation of Birt-Hogg-Dubé Syndrome
Authors: Yoshida Kazuki , Miyagawa Masao , Kido Teruhito , Ide Kana , Sano Yoshifumi , Sugawara Yoshifumi , Takahata Hiroyuki , Monden Nobuya , Furuya Mitsuko , Mochizuki Teruhito
Published: June 2018

Birt-Hogg-Dubé syndrome (BHD) is a rare autosomal dominant disease characterized by skin fibrofolliculomas, pulmonary cysts, spontaneous pneumothoraces, and renal cancers. Oncocytomas are benign epithelial tumors that are also rare. Recently, there have been a few case reports of BHD with a parotid oncocytoma that appears to have a BHD phenotype. Here we document the eighth known case and describe the magnetic resonance imaging features of the parotid oncocytoma, which mimicked Warthin’s tumor. Radiologists should be aware of the association between these rare disorders.
Impaired Mitophagy of Nucleated Erythroid Cells Leads to Anemia in Patients with Myelodysplastic Syndromes
Authors: Jiang Huijuan , Yang Liyan , Guo Lifang , Cui Ningbo , Zhang Gaochao , Liu Chunyan , Xing Limin , Shao Zonghong , Wang Huaquan
Published: June 2018

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by cytopenia and dysplasia. Anemia is the most common symptom in patients with MDS. Mitophagy and mitochondrial dysfunction might be involved in the development of MDS. In this study, we investigated the change of mitophagy in erythroid precursors in MDS patients. We found that NIX‐mediated mitophagy was impaired in bone marrow nucleated red blood cells (NRBC) of MDS patients, associated with an increased amount of damaged mitochondria and increased ROS level which might lead to apoptosis and ineffective erythropoiesis. The results showed that the amount of mitochondria in GlycoA+ NRBC positively correlated with the count of ring sideroblasts in bone marrow samples. Meanwhile, the level of autophagy‐associated marker LC3B in GlycoA+ NRBC had a positive correlation with hemoglobin (Hb) levels, and the amount of mitochondria in GlycoA+ NRBC had a negative correlation with Hb levels in high‐risk MDS patients. Our results indicated that mitophagy might involve the pathogenesis of anemia associated with MDS. Autophagy might be a novel target in treatments of MDS patients.
Light Leakage of Multidomain Vertical Alignment LCDs Using a Colorimetric Model in the Dark State
Authors: Tien Chuen-Lin , Lin Rong-Ji , Yeh Shang-Min
Published: June 2018

Light leakage from liquid crystal displays in the dark state is relatively larger and leads to a degraded contrast ratio and color shift. This work describes a novel colorimetric model based on the Muller matrix that includes depolarization of light propagating through liquid crystal molecules, polarizers, and color filters. In this proposed model, the chromaticity can be estimated in the bump and no-bump regions of an LCD. We indicate that the difference between simulation and measurement of chromaticity is about 0.01. Light leakage in the bump region is three times that in no-bump region in the dark state.
The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study
Authors: Muzaffar Mahvish , Johnson Helen M. , Vohra Nasreen A. , Liles Darla , Wong Jan H.
Published: June 2018

Background.Inflammatory breast cancer (IBC) is a rare but most aggressive breast cancer subtype. The impact of locoregional therapy on survival in IBC is controversial.Methods.Patients with nonmetastatic IBC between 1988 and 2013 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry.Results.We identified 7,304 female patients with nonmetastatic inflammatory breast cancer (IBC) who underwent primary tumor surgery. Most patients underwent total mastectomy with only 409 (5.6%) undergoing a partial mastectomy. In addition, 4,559 (62.4%) were also treated with radiation therapy. The patients who underwent mastectomy had better survival compared to partial mastectomy (49% versus 43%,p= 0.003). The addition of radiation therapy was also associated with improved 5-year survival (55% versus 40%,p< 0.001). Multivariate analysis showed that black race HR (1.22, 95% CI 1.18–1.35), ER negative status (HR 1.22, 95% CI 1.16–1.28), and higher grade (HR 1.14, 95% CI 1.07–1.20) were associated with poor outcome. Cox proportional hazards model showed that total mastectomy (HR 0.75, 95% CI 0.65–0.85) and radiation (HR 0.64, 95% CI 0.61–0.69) were associated with improved survival.Conclusions. Optimal locoregional therapy for women with nonmetastatic IBC continues to be mastectomy and radiation therapy. These data reinforce the prevailing treatment algorithm for nonmetastatic IBC.
Cross-Talk between Gut Microbiota and Heart via the Routes of Metabolite and Immunity
Authors: Bu Jin , Wang Zhaohui
Published: June 2018

Considering the prevalence of cardiovascular disease (CVD), significant interest has been focused on the gut microbiota-heart interaction because the gut microbiota has been recognized as a barometer of human health. Dysbiosis, characterized by changes in the gut microbiota in CVD, has been reported in cardiovascular pathologies, such as atherosclerosis, hypertension, and heart failure. Conversely, gut microbiota-derived metabolites, such as trimethylamine/trimethylamineN-oxide (TMA/TMAO), can impact host physiology. Further, bacterial dysbiosis can disturb gut immunity, which increases the risk of acute arterial events. Moreover, studies of germ-free mice have provided evidence that microbiota diversity and the presence of a specific microbe in the gut can affect immune cells in hosts. Therefore, the changes in the composition of the gut microbiota can affect host metabolism and immunity. Importantly, these effects are not only confined to the gut but also spreaded to distal organs. The purpose of the current review is to highlight the complex interplay between the microbiota and CVD via TMAO and different immune cells and discuss the roles of probiotics and nutrition interventions in modulating the intestinal microbiota as novel therapeutic targets of CVD.
Secondary Bleedings in Oral Surgery Emergency Service: A Cross-Sectional Study
Authors: Igelbrink Sebastian , Burghardt Stefan , Michel Barbara , Kübler Norbert R. , Holtmann Henrik
Published: June 2018

Introduction. Bleeding after dental surgery is still a common cause for emergency presentation in patients using anticoagulants. Our aim was to analyze pertinent characteristic features on the one hand and to bare existing problems in handling on the other. Materials and Methods. The study included 76 patients. We documented basic data, anticoagulant medication, type of surgery, and tooth socket sutures in respective patients. Results. The vast majority of patients took a coumarin derivative (41) and acetylsalicylic acid (27). Nine (12%) of the patients had to be hospitalized due to ongoing bleeding despite local haemostyptic steps and/or circulatory dysregulation. Most patients could be successfully treated in outpatient settings. No statistically significant correlation between bleeding, level of INR value, number of extracted teeth, and sewed alveoli could be shown. Sixty-five percent of cases with tooth extractions did not have suture of tooth sockets. Eighty-seven percent of the patients denied being informed about possible self-treatment options by their surgeon/dentist, and none of the patients got presurgical-fabricated bandage plate(s). Conclusions. Patients taking coumarin derivative currently, furthermore, represent the biggest anticoagulant after-bleeding group in dentoalveolar surgery. The major part of after-bleedings (90%) can be handled in an outpatient setting with simplest surgical interventions. Unfortunately, the biggest part of the patient collective got no suture, no prefabricated dental bandage plate(s), and no explanation by their dentist how to handle in case of after-bleeding. Therefore, dental practitioners should furthermore get enlightenment on how to prevent after-bleeding situations.
Mechanical Properties of Steel Fibers and Nanosilica Modified Crumb Rubber Concrete
Authors: Wang Yihong , Chen Jiawei , Gao Danying , Huang E.
Published: June 2018

Crumb rubber concrete (CRC) is an environment‐friendly material using crumb rubber as a composition of cement concrete. It provides an alternative method for recycling of waste tires scientifically. CRC exhibits numerous advantages compared to ordinary concrete. However, the application of CRC is limited due to its low compressive and tensile strengths. This paper puts forward a new modified method by adding steel fibers and nanosilica in CRC. Material properties’ testing of eighteen concrete mixtures was investigated, considering different strength grades of CRC and crumb rubber contents. In addition, four different steel fiber contents (0%, 0.5%, 1.0%, and 1.5%) and three different nanosilica content (0%, 1%, and 2%) were taken into consideration. The brittle failure of the CRC can be improved and the mechanical properties can be enhanced according to the test results. More importantly, the modified CRC with 1.0% steel fiber content has relatively high compressive and splitting tensile strengths. Furthermore, the noncompactness of CRC can be effectively improved by nanosilica, enhancing the efficiency of steel fibers simultaneously. Finally, the failure mechanism of the modified CRC is discussed in this paper.
Effect of Helicobacter pylori Infection on Serum Lipid Profile
Authors: Haeri Mohamadreza , Parham Mahmoud , Habibi Neda , Vafaeimanesh Jamshid
Published: June 2018

Background. Some studies suggest a significant relationship between Helicobacter pylori infection and atherogenesis; but the mechanism of the relationship is almost unknown. The current study aimed at evaluating the relationship between H. pylori infection and serum lipid profile. Patients and Methods. The current study was conducted on 2573 patients, from 2008 to 2015. The serum anti-Helicobacter pylori antibody titer and serum lipid profile were assessed in the study population; data were statistically analyzed by SPSS version 16. P values < 0.05 were considered significant. Results. In the current study, 66.5% of the cases were serologically positive for H. pylori. Among male cases, the level of low density lipoprotein (LDL) was higher in patients with H. pylori infection, compared with that of the ones without the infection (P=0.03); although level of triglyceride (TG) was higher and the level of high density lipoprotein (HDL) was lower in the cases with H. pylori infection; there was no statistically significant difference between the cases with and without H. pylori infection regarding the level of HDL and TG. Among female cases, the level of TG was significantly lower in patients with H. pylori infection, compared with that of the ones without the infection (P=0.001); but there was no significant difference between the cases with and without H. pylori infection regarding the level of LDL and HDL. The mean fasting blood sugar (FBS) in the cases with H. pylori infection was significantly higher than that of the ones without the infection (P=0.04). Conclusion. According to the results of the current study, the levels of LDL and FBS were high among the male cases with H. pylori infection. However, in females with H. pylori infection the level of TG was low; hence, it seems that the atherogenicity of H. pylori affected the level of blood sugar more.
A Simple Model for Elastic‐Plastic Contact of Granular Geomaterials
Authors: Wang Jian , Li Qimin , Yang Changwei , Huang Yidan , Zhou Caizhi
Published: June 2018

We propose a simple elastic‐plastic contact model by considering the interaction of two spheres in the normal direction, for use in discrete element method (DEM) simulations of geomaterials. This model has been developed by using the finite element method (FEM) and nonlinear fitting methods, in the form of power‐law relation of the dimensionless normal force and displacement. Only four parameters are needed for each loading‐unloading contact process between two spheres, which are relevant to material properties evaluated by FEM simulations. Within the given range of material properties, those four parameters can be quickly accessed by interpolating the data appended or by regression functions supplied. Instead of the Von Mises (V‐M) yield criterion, the Drucker–Prager (D‐P) criterion is used to describe the yield behavior of contacting spheres in this model. The D‐P criterion takes the effects of confining pressure, the intermediate principal stress, and strain rate into consideration; thus, this model can be used for DEM simulation of geomaterials as well as other granular materials with pressure sensitivity.
Biochar and/or Compost Applications Improve Soil Properties, Growth, and Yield of Maize Grown in Acidic Rainforest and Coastal Savannah Soils in Ghana
Authors: Mensah Albert Kobina , Frimpong Kwame Agyei
Published: June 2018

Use of biochar for soil fertility improvement is gaining popularity due to its potential to improve soil quality, increase crop yield, and sequester carbon from the atmosphere-biosphere pool into the soil. A 40-day pot experiment was carried out to investigate the effects of corncob biochar and compost applied alone (at a rate of 2%, w/w) or in combination (1% of each, thus 1% compost + 1% biochar) on soil physicochemical properties, growth, and yield of maize on two soils of contrasting pH and texture collected from the Rainforest and Coastal Savannah agroecological zones of Ghana. Biochar and compost applied alone or in combination significantly increased soil pH, total organic carbon, available phosphorus, mineral nitrogen, reduced exchangeable acidity, and increased effective cation exchange capacity in both soils. Additionally, combined application and single application biochar or compost additions increased the plant height, stem girth, and dry matter yields of two maize (local (“ewifompe”) and hybrid (Obaatanpa)) varieties used in the study. The study showed that biochar applied alone or in combination with compost offers the potential to enhance soil quality and improve maize yield.
Protection of Corneal Limbus from Riboflavin Prevents Epithelial Stem Cell Loss after Collagen Cross-Linking
Authors: Lee Hyo Kyung , Ryu Jin Suk , Jeong Hyun Jeong , Kim Mee Kum , Oh Joo Youn
Published: June 2018

Purpose. To investigate whether the protection of corneal limbus from riboflavin exposure during collagen cross-linking (CXL) prevents limbal epithelial stem cell (LESC) loss. Methods. Ten New Zealand white rabbits received an epithelium-off CXL using an accelerated protocol. Seven days before procedure, 5-bromo-2-deoxyuridine (BrdU) was intraperitoneally injected. During procedure, riboflavin was applied to the corneal surface within a 9 mm diameter retention ring in 5 rabbits, thereby preventing the limbus from riboflavin exposure. In other 5 rabbits, riboflavin was instilled every 2 min, allowing the spillover to the limbus. One day after UVA irradiation, corneas were subjected to histological and molecular assays. Results. There were no differences in corneal thickness and epithelial healing between the groups. The numbers of BrdU-labelled and p63+ limbal epithelial cells were markedly reduced in the group without a ring, but significantly increased when a ring was used. Robust expression of CK3/12 was observed in the limbal epithelium in the group with a ring. The mRNA levels of ABCG2, FGF2, IL-1β, and IL-6 were significantly increased in the corneas with a ring. Conclusions. Protection of limbus from riboflavin during CXL was effective in preserving LESCs. However, inflammation was increased in the cornea treated with riboflavin using a ring.
Cytokine Secretion of Peripheral Blood Mononuclear Cells by Hydnocarpus anthelminthicus Seeds
Authors: Leelawat Surang , Leelawat Kawin
Published: June 2018

Background. Hydnocarpus anthelminthicus is primarily used as a traditional medicine for the treatment of leprosy. Previous studies demonstrated that the clinical course of leprosy and the susceptibility to mycobacteria are recognized by the immune response of the host. The current study aims to investigate the effect of H. anthelminthicus seed oil and extracts on the secretion of cytokines from PBMCs involved in immune regulation. Methods. PBMCs from healthy volunteers were cultured and treated with LPS and H. anthelminthicus seed oil or extracts. Cell viability was detected with WST-1 cell proliferation assay reagent. Proinflammatory cytokines were quantified using ELISA with a specific antibody. Results. LPS-treated PBMCs significantly increased IL6 and TNF-α secretion. H. anthelminthicus seed oil had a synergistic effect with LPS on TNF-α secretion. The aqueous extract of H. anthelminthicus seed kernels and hulls significantly induced IL6 and TNF-α secretion. However, the ethanol extract of H. anthelminthicus seed kernels and hulls significantly decreased IL6, IL8, and TNF-α secretion in LPS-treated PBMCs. Conclusions. Extracts of H. anthelminthicus seeds demonstrated various effects on the proinflammatory cytokine secretion of PBMCs. The application of these extracts should depend on the immune response of the host, which determines the manifestation of the disease.
Absence of the Rashba Splitting of Au(111) Surface Bands
Authors: Yakovkin I. N.
Published: June 2018

The electronic structure of Au(111) films is studied by means of relativistic DFT calculations. It is found that the twinning of the surface bands, observed in photoemission experiment, does not necessarily correspond to the spin-splitting of the surface states caused by the break of the inversion symmetry at the surface. The twinning of the bands of clean Au(111) films can be obtained within nonrelativistic or scalar-relativistic approximation, so that it is not a result of spin-orbit coupling. However, the spin-orbit coupling does not lead to the spin-splitting of the surface bands. This result is explained by Kramers’ degeneracy, which means that the existence of a surface itself does not destroy the inversion symmetry of the system. The inversion symmetry of the Au(111) film can be broken, for example, by means of adsorption, and a hydrogen monolayer deposited on one face of the film indeed leads to the appearance of the spin-splitting of the bands.
People, Means, and Activities: A Conceptual Framework for Realizing the Educational Potential of Makerspaces
Authors: Hira Avneet , Hynes Morgan M.
Published: June 2018

Makerspaces are environments where individuals use technologies to make physical artifacts within a community of fellow Makers. There has been growing interest in the educational potential of Making activities which has resulted in many schools procuring tools and technologies to set up their Makerspaces. However, there is scant research investigating the efficacy of Making these newly emerging Makerspaces intended for learning. In our work, we narrow this gap in knowledge between the claimed educational potential of Making and its attainment. By synthesizing prior work and publically available data on Makerspaces, we introduce a framework to situate the educational considerations for Makerspaces and recommend directions for future research on educational Makerspaces. Being cognizant of the Maker culture having emerged outside of the academic literature, we synthesize publically available data from 53 untraditional but relevant sources. These sources include definitions of Making forwarded by 3 well-established Maker initiatives (Makerspace, Hackerspace, and Fab Lab), 18 relevant sites of Making activities across the United States, 17 sites from other countries (namely, China, India, Morocco, and Spain), and 15 Maker initiatives at schools in the United States. After proposing and detailing the framework, we recommend directions for future research to attain the potential of educational Making.
Primitive Idempotents of Irreducible Cyclic Codes of Length n
Authors: Lin Yuqian , Yue Qin , Wu Yansheng
Published: June 2018

Let Fq be a finite field with q elements and n a positive integer. In this paper, we use matrix method to give all primitive idempotents of irreducible cyclic codes of length n, whose prime divisors divide q-1.
Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability
Authors: Kahl Vivian F. Silva , Dhillon Varinderpal , Fenech Michael , de Souza Melissa Rosa , da Silva Fabiane Nitzke , Marroni Norma Anair Possa , Nunes Emilene Arusievicz , Cerchiaro Giselle , Pedron Tatiana , Batista Bruno Lemos , Cappetta Mónica , Mártinez-López Wilner , Simon Daniel , da Silva Juliana
Published: June 2018

Pesticides used at tobacco fields are associated with genomic instability, which is proposed to be sensitive to nutritional intake and may also induce epigenetic changes. We evaluated the effect of dietary intake and genetic susceptibility polymorphisms in MTHFR (rs1801133) and TERT (rs2736100) genes on genomic and epigenetic instability in tobacco farmers. Farmers, when compared to a nonexposed group, showed increased levels of different parameters of DNA damage (micronuclei, nucleoplasmic bridges, and nuclear buds), evaluated by cytokinesis‐block micronucleus cytome assay. Telomere length (TL) measured by quantitative PCR was shorter in exposed individuals. Global DNA methylation was significantly decreased in tobacco farmers. The exposed group had lower dietary intake of fiber, but an increase in cholesterol; vitamins such as B6, B12, and C; β‐carotene; and α‐retinol. Several trace and ultratrace elements were found higher in farmers than in nonfarmers. The MTHFR CT/TT genotype influenced nucleoplasmic bridges, nuclear buds, and TL in the exposed group, whereas TERT GT/TT only affected micronucleus frequency. We observed a positive correlation of TL and lipids and an inverse correlation of TL and fibers. The present data suggest an important role of dietary intake and subjects’ genetic susceptibility to xenobiotics‐induced damages and epigenetic alterations in tobacco farmers occupationally exposed to mixtures of pesticides.
Generalized Fractional Integral Operators Involving Mittag-Leffler Function
Authors: Amsalu Hafte , Suthar D. L.
Published: June 2018

The aim of this paper is to study various properties of Mittag-Leffler (M-L) function. Here we establish two theorems which give the image of this M-L function under the generalized fractional integral operators involving Fox’s H-function as kernel. Corresponding assertions in terms of Euler, Mellin, Laplace, Whittaker, and K-transforms are also presented. On account of general nature of M-L function a number of results involving special functions can be obtained merely by giving particular values for the parameters.
Bioimmobilized Limestone Powder for Autonomous Healing of Cementitious Systems: A Feasibility Study
Authors: Shaheen Nafeesa , Khushnood Rao Arsalan , Ud din Siraj
Published: June 2018

For preserving concrete structures and hindering ingress of chemicals through cracks and fissures, repair is inevitable. Microbial calcite precipitation is an intrinsic approach for crack rectification and emulating way of sustainability for reducing anthropogenic greenhouse gases (GHGs) along with conserving the natural resources. In this study, Bacillus subtilis strain is applied for intrinsic repair of concrete’s cracks because of its high pH endurance and capability of sporulation. For prolonged survival of microorganisms, immobilization technique was employed. B. subtilis was immobilized through limestone powder (LSP) before adding into cement matrix. Self‐healing proficiency of B. subtilis was deliberated in terms of mechanical strength regain after cracking at 3, 7, 14, and 28 days. To examine the microstructure and characterization of healing precipitate, micrographical (field emission scanning electron microscopy), chemical (energy dispersive X‐ray), and thermal (thermogravimetric analysis) analyses were performed after the healing period of 28 days. The results revealed evident signs of calcite precipitation in nano‐/microcracks subsequent to microbial activity. Furthermore, immobilized LSP improved the compressive strength of the analyzed formulations.
Reducing Subspaces of the Dual Truncated Toeplitz Operator
Authors: Hu Yinyin , Deng Jia , Yu Tao , Liu Liu , Lu Yufeng
Published: June 2018

We define the dual truncated Toeplitz operators and give some basic properties of them. In particular, spectrum and reducing subspaces of some special dual truncated Toeplitz operator are characterized.
Elective “True Day Case” Laparoscopic Inguinal Hernia Repair in a District General Hospital: Lessons Learned from 1000 Consecutive Cases
Authors: Solodkyy A. , Feretis M. , Fedotovs A. , Di Franco F. , Gergely S. , Harris A. M.
Published: June 2018

Introduction. Laparoscopic inguinal hernia repair (LIHR) is ideal for day case surgery. It is recommended that at least 70% should be day cases as a measure of cost-effectiveness. The aims of this study were to (i) assess the rate of true day case (TDC) surgery and (ii) identify predictors associated with unexpected overnight stay (UOS). Methods. Data was collected prospectively on 1000 consecutive elective LIHR performed in a District General Hospital (DGH) over a 7-year period. Data was collected on baseline patient demographics, ASA grade, and intraoperative details. A multivariate analysis was performed in order to identify predictors of UOS. Results. 1000 patients (927 males) underwent elective LIHR. Mean age was 57.3±15.2 years. 915 patients were planned as day case procedures. 822/915 day cases (89.8%) were discharged on the same day and 93 (10.2%) stayed overnight unexpectedly. Patient age, duration of procedure, and patient slot in the operating list were found to be independent predictors (p<0.05) of UOS. Conclusion. Our results demonstrate that LIHR is a “true” day case procedure in a DGH. Although some factors associated with UOS cannot be altered, careful patient selection and operating list planning are of paramount importance in order to minimise the burden on healthcare resources.