bluuebunny/crossref_metadata_2025 huggingface dataset:
Gender Differences in the Associations Between Physical Activity, Smartphone Use, and Weight Stigma
Authors: Xu Ping , Chen Jung-Sheng , Chang Yen-Ling , Wang Xiaodong , Jiang Xingyong , Griffiths Mark D. , Pakpour Amir H. , Lin Chung-Ying
Published: March 2022

Background

Physical activity (PA) is important for health. However, there is little evidence on how weight stigma, time spent on sedentary activities (including smartphone, social media, online learning), time spent on outdoor activity, and nomophobia associate with PA among Chinese individuals with consideration of gender. The present study examined the aforementioned associations in the COVID-19 pandemic era.

Methods

University students (N = 3,135; 1,798 females, 1,337 males) with a mean age of 19.65 years (SD = 2.38) years completed an online survey from November to December, 2021. The online survey assessed weight stigma (using the Perceived Weight Stigma Scale and Weight Bias Internalization Scale), PA (using the International Physical Activity Questionnaire Short Form), time spent on different activities (using self-designed items for time on smartphone, outdoor activity, social media, and online learning), and nomophobia (using the Nomophobia Questionnaire). Parallel mediation models were constructed (dependent variable: PA; mediators: perceived weight stigma, weight-related self-stigma, time spent on smartphone, time spent on outdoor activity, time spent on social media, and time spent online learning; independent variable: nomophobia) and evaluated using Hayes' Process Macro Model 4 (IBM SPSS 20.0).

Results

Weight-related self-stigma (β = −0.06; p = 0.03), time spent on outdoor activity (β = 0.21; p < 0.001), time spent on social media (β = 0.07; p = 0.02), time spent on online learning (β = 0.06; p = 0.03), and nomophobia (β = −0.07; p = 0.01) were all significant factors explaining the PA among female participants. Perceived weight stigma (β = −0.07; p = 0.01), time spent on outdoor activity (β = 0.27; p < 0.001), and time spent on online learning (β = 0.10; p = 0.002) were all significant factors explaining PA among male participants.

Conclusion

Chinese healthcare providers should design programs on weight stigma reduction and outdoor activity improvement to enhance PA among university students.
Validity and Psychometric Evaluation of the Chinese Version of the 5-Item WHO Well-Being Index
Authors: Fung Sai-fu , Kong Chris Yiu Wah , Liu Yi-man , Huang Qian , Xiong Zike , Jiang Zhiquan , Zhu Fangfang , Chen Zhenting , Sun Kun , Zhao Huiqin , Yu Ping
Published: March 2022

Aims

This article evaluates the psychometric properties of the Chinese version of the 5-item WHO Well-Being Index (WHO-5) in mainland China.

Methods

Two cross-sectional studies with 1,414 participants from a university in China were conducted. The Chinese version of the WHO-5 was assessed to determine its internal consistency, concurrent validity, factorial validity, and construct validity.

Results

The results indicate that the WHO-5 is unidimensional and has good internal consistency, with Cronbach'sa= 0.85 and 0.81 in Study 1 (n= 903) and Study 2 (n= 511), respectively. The findings also demonstrate that the WHO-5 has good concurrent validity with other well-established measures of wellbeing, self-efficacy, self-esteem, and mental wellbeing. The results of confirmatory factor analysis also suggest that the scale has a good model fit.

Conclusions

This study provides empirical data demonstrating that the Chinese version of the WHO-5 has good psychometric properties. The scale can be a useful measure in epistemological studies and clinical research related to wellbeing in Chinese populations.
Backchannel Behavior Influences the Perceived Personality of Human and Artificial Communication Partners
Authors: Blomsma Peter , Skantze Gabriel , Swerts Marc
Published: March 2022

Different applications or contexts may require different settings for a conversational AI system, as it is clear that e.g., a child-oriented system would need a different interaction style than a warning system used in emergency situations. The current article focuses on the extent to which a system's usability may benefit from variation in the personality it displays. To this end, we investigate whether variation in personality is signaled by differences in specific audiovisual feedback behavior, with a specific focus on embodied conversational agents. This article reports about two rating experiments in which participants judged the personalities (i) of human beings and (ii) of embodied conversational agents, where we were specifically interested in the role of variability in audiovisual cues. Our results show that personality perceptions of both humans and artificial communication partners are indeed influenced by the type of feedback behavior used. This knowledge could inform developers of conversational AI on how to also include personality in their feedback behavior generation algorithms, which could enhance the perceived personality and in turn generate a stronger sense of presence for the human interlocutor.
Development of a Novel Framework for the Assessment and Improvement of Climate Adaptation and Mitigation Actions in Europe
Authors: Ottaviani Aalmo Giovanna , Gioli Beniamino , Rodriguez Divina Gracia P. , Tuomasjukka Diana , Liu Hai-Ying , Pastore Maria Chiara , Salbitano Fabio , Bogetoft Peter , Sæbø Arne , Konijnendijk Cecil
Published: March 2022

The greenhouse gases (GHG) emissions in the European Union (EU) are mainly caused by human activity from five sectors—power, industry, transport, buildings, and agriculture. To tackle all these challenges, the EU actions and policies have been encouraging initiatives focusing on a holistic approach but these initiatives are not enough coordinated and connected to reach the much needed impact. To strengthen the important role of regions in climate actions, and stimulate wide stakeholders' engagement including citizens, a conceptual framework for enabling rapid and far-reaching climate actions through multi-sectoral regional adaptation pathways is hereby developed. The target audience for this framework is composed by regional policy makers, developers and fellow scientists. The scale of the framework emphasizes the regional function as an important meeting point and delivery arena for European and national climate strategies and objectives both at urban and rural level. The framework is based on transformative and no-regret measures, prioritizing the Key Community Systems (KCS) that most urgently need to be protected from climate impacts and risks.
Applying a Multi-Method Framework to Analyze the Multispectral Acoustic Response of the Seafloor
Authors: Menandro Pedro S. , Bastos Alex C. , Misiuk Benjamin , Brown Craig J.
Published: March 2022

Improvements to acoustic seafloor mapping systems have motivated novel marine geological and benthic biological research. Multibeam echosounders (MBES) have become a mainstream tool for acoustic remote sensing of the seabed. Recently, “multispectral” MBES backscatter, which is acquired at multiple operating frequencies, has been developed to characterize the seabed in greater detail, yet methods for the use of these data are still being explored. Here, we evaluate the potential for seabed discrimination using multispectral backscatter data within a multi-method framework. We present a novel MBES dataset acquired using four operating frequencies (170, 280, 400, and 700 kHz) near the Doce River mouth, situated on the eastern Brazilian continental shelf. Image-based and angular range analysis methods were applied to characterize the multifrequency response of the seabed. The large amount of information resulting from these methods complicates a manual seabed segmentation solution. The data were therefore summarized using a combination of dimensionality reduction and density-based clustering, enabling hierarchical spatial classification of the seabed with sparse ground-truth. This approach provided an effective solution to synthesizing these data spatially to identify two distinct acoustic seabed classes, with four subclasses within one of the broader classes, which corresponded closely with seafloor sediment samples collected at the site. The multispectral backscatter data also provided information in likely, unknown, sub-surface substrate differences at this site. The study demonstrates that the adoption of a multi-method framework combining image-based and angular range analysis methods with multispectral MBES data can offer significant advantages for seafloor characterization and mapping.
Sustainability Assessment in Manufacturing for Effectiveness: Challenges and Opportunities
Authors: Kumar Manish , Mani Monto
Published: March 2022

Manufacturing organizations continuously improve their energy, environmental, and economic performance at different manufacturing levels (products, processes, enterprise, etc.) using various assessment methodologies for visibility and a competitive market edge. Sustainability assessment has become the focus of the manufacturing performance measurement in the last decade and has triggered numerous methodological developments and adoption in practice. The assessment focus has broadened from process to enterprise-level, single to multiple parameters, fragmented to a holistic point of view, and local businesses to global sustainability and circularity. Increasing global environmental burden, resource scarcity, and human health challenges urge a shift toward effective assessment practices. This article critically reviews sustainability assessment practices in manufacturing from a methodological efficiency-effectiveness perspective. A clear distinction between efficiency and effectiveness practices has been discussed. The requirements and research challenges for effectiveness in the sustainability assessment practice in theory (academia) and practice (industry) is presented.
What Do We Mean by “Climate” and “Climate Change”?
Authors: Regoto Pedro , Burgard Clara , Jones Chris
Published: March 2022

Climate change is all over the news. But what exactly do we mean by “climate” and “climate change?” The word “climate” describes the average state of the atmosphere. It is a result of the composition and interactions between the natural elements: the air, oceans, plants and animals, ice and snow, and rocks. There are several different climate zones around the world. The state of the global climate is described by the average global air temperature. This temperature depends on how much heat the Earth receives from the Sun and how much of this heat is sent back to space. If the amount of heat received through the sun’s rays or the composition of one or several of the natural elements changes, the amount of heat taken up by the Earth changes. All elements are connected and constantly interacting, and this has consequences for the whole planet: climate change.
Integrated Soil Health Management for Plant Health and One Health: Lessons From Histories of Soil-borne Disease Management in California Strawberries and Arthropod Pest Management
Authors: Muramoto Joji , Parr Damian Michael , Perez Jan , Wong Darryl G.
Published: March 2022

Many soil health assessment methods are being developed. However, they often lack assessment of soil-borne diseases. To better address management strategies for soil-borne disease and overall soil and plant health, the concept of Integrated Soil Health Management (ISHM) is explored. Applying the concept of Integrated Pest Management and an agroecological transdisciplinary approach, ISHM offers a framework under which a structure for developing and implementing biointensive soil health management strategies for a particular agroecosystem is defined. As a case study, a history of soil-borne disease management in California strawberries is reviewed and contrasted with a history of arthropod pest management to illustrate challenges associated with soil-borne disease management and the future directions of soil health research and soil-borne disease management. ISHM system consists of comprehensive soil health diagnostics, farmers' location-specific knowledge and adaptability, a suite of soil health management practices, and decision support tools. As we better understand plant-soil-microorganism interactions, including the mechanisms of soil suppressiveness, a range of diagnostic methodologies and indicators and their action thresholds may be developed. These knowledge-intensive and location-specific management systems require transdisciplinary approaches and social learning to be co-developed with stakeholders. The ISHM framework supports research into the broader implications of soil health such as the “One health” concept, which connects soil health to the health of plants, animals, humans, and ecosystems and research on microbiome and nutrient cycling that may better explain these interdependencies.
Fermented Wheat Bran Polysaccharides Intervention Alters Rumen Bacterial Community and Promotes Rumen Development and Growth Performance in Lambs
Authors: Wang Wenwen , Wang Yuan , Cui Zhiwei , Yang Yi , An Xiaoping , Qi Jingwei
Published: March 2022

There is growing interest in the utilization of plant polysaccharides for the modulation of the rumen bacterial community and enhancement of growth performance in ruminants. Fermented wheat bran polysaccharides (FWBPs), plant polysaccharides, have been shown to improve the growth performance of lambs, but little is known about their effect on rumen bacteria. The aim of this study was to investigate the effects of FWBPs supplementation to milk replacer (MR) on the growth performance, blood metabolites, weight and morphology of rumen, rumen fermentation, and rumen bacterial community which were investigated in lambs. Twelve 1.5-month-old crossbred lambs (Dorper × Small-tailed Han Sheep) with an initial body weight (BW) of 11.38 ± 0.19 kg were randomly divided into two groups, namely, the control group and FWBPs group. Compared with the control group, the FWBPs group had a higher average daily weight gain and serum total protein concentrations, and a lower feed: gain ratio. A tendency of increase in final BW and carcass BW was also observed. Administration of FWBPs increased the ruminal papillae width and ruminal butyrate proportion and decreased the concentration of ammonia nitrogen and the proportion of isobutyrate and isovalerate. In addition, the epithelial cell thickness had an increased trend in the FWBPs group. High-throughput sequencing data showed that the relative abundance of Lachnospiraceae_NK3A20_group and Solobacterium was enhanced by FWBP treatment; meanwhile, the relative abundance of NK4A214_group, Megasphaera, and Treponema showed a tendency to be higher than that of the control group. Furthermore, Spearman's correlation analysis revealed that the relative abundances of NK4A214_group, Treponema, and Lachnospiraceae_NK3A20_group were positively correlated with butyrate proportion. Collectively, FWBPs supplementation to MR on lambs altered the rumen bacterial community, promoted rumen development, and improved growth performance.
Stability Studies of 16 Antibiotics for Continuous Infusion in Intensive Care Units and for Performing Outpatient Parenteral Antimicrobial Therapy
Authors: Loeuille Guillaume , D’Huart Elise , Vigneron Jean , Nisse Yann-Eric , Beiler Benoit , Polo Caroline , Ayari Gillian , Sacrez Matthieu , Demoré Béatrice , Charmillon Alexandre
Published: March 2022

The use of continuous infusion to improve the therapeutic efficacy of time-dependent antibiotics has been demonstrated. There is still a lack of data to safely perform these continuous infusions. The objectives in this study were to evaluate the stability by using stability-indicating methods (High-Performance Liquid Chromatography) of 16 antibiotics in concentrated solutions, especially for administration in intensive care units and solutions in elastomeric diffusers at 37 °C for outpatient parenteral antimicrobial therapy. The solutions were considered stable if the percentage of the drug was ≥90%, and the colour and clearness remained unchanged. In syringes, the stability data vary from 4 to 8 h (h) for meropenem in Dextrose 5% (D5W) and Normal Saline (NS), respectively, 6 h for cefotaxime, 12 h for cefoxitin, and 24 h for aztreonam, cefazolin, cefepime, cefiderocol, ceftazidime/avibactam, ceftolozane/tazobactam in NS and D5W, and in water for injection for cloxacillin. A stability period of 48 h has been validated for vancomycin (D5W), aztreonam, and piperacillin/tazobactam. Cefoxitin, cefazolin, cefepime, cefotaxime, cloxacillin, and piperacillin are unstable for diffuser administration. In diffusers, stability times vary from 6 h for cefiderocol, 8 h for ceftazidime, 12 h for ceftazidime/avibactam and ceftolozane/tazobactam (NS), 24 h for temocillin (NS) and piperacillin/tazobactam (D5W), up to 48 h for aztreonam and vancomycin. Solutions stored at 37 °C are less stable and allow the administration of seven antibiotics using diffusers.
Joint Distribution Analysis of Forest Fires and Precipitation in Response to ENSO, IOD, and MJO (Study Case: Sumatra, Indonesia)
Authors: Nurdiati Sri , Sopaheluwakan Ardhasena , Septiawan Pandu
Published: March 2022

To evaluate the impact of the El Niño Southern Oscillation (ENSO), Indian Ocean Dipole (IOD), and Madden Julian Oscillation (MJO) on the occurrence of land and forest fire in Sumatra, copula-based joint distribution analysis and quadrant analysis (for extreme events) were carried out in this research. This research used dry spells (number of days without rain) and precipitation anomalies as climate indicators and hotspots as land and forest fire indicators. Using data spanning from 2001 to 2020, this research shows that ENSO and IOD strongly influence hotspots in Sumatra with monsoonal-type precipitation. Even though the impact is not linear, the probability of a higher number of hotspots occurring increases significantly, especially during strong El Niño and weak El Niño combined with positive IOD. Furthermore, the results show that moderate El Niño has a similar impact to weak El Niño on the affected area, while weak El Niño combined with positive IOD can result in effects similar to robust El Niño impact. Meanwhile, this research has shown that the MJO affects hotspots in the first dry season of Sumatran areas that have equatorial-type precipitation. Although its impact on dry spell–precipitation anomaly dependency is unclear, phases 6,7, and 8 of MJO significantly increase dry spell–hotspot dependency during dry conditions.
A Sensitivity Study on High Resolution NWP ICON—LAM Model over Italy
Authors: De Lucia Carmine , Bucchignani Edoardo , Mastellone Andrea , Adinolfi Marianna , Montesarchio Myriam , Cinquegrana Davide , Mercogliano Paola , Schiano Pasquale
Published: March 2022

In this work, the results of a sensitivity study based on ICON-LAM simulations at 2.5 km of spatial resolution over the Italian area, driven by ECMWF IFS global data, are presented. The main aim is to provide a contribution to the selection of suitable parameterization schemes that result in more effective for a proper representation of the Italian climate features. Model evaluation was conducted in terms of the air temperature and precipitation for three subregions, comparing a set of 13 simulations against SCIA and E-OBS standard datasets. In addition, evaluation was also conducted against selected data stations scattered over the Italian area. We found that the ICON-LAM model was able to provide a good representation of the temperature over Italy, whereas non-negligible biases were observed for precipitation in certain regions. The model proved to be sensitive to changes in physical parameterization schemes. In particular, we found that the explicit treatment of deep convection and the “clouds as in turbulence” scheme for cloud cover allowed for a better representation of precipitation in the summer over the Alpine region. The single moment scheme is currently the best option for cloud microphysics.
China’s Port Carbon Emission Reduction: A Study of Emission-Driven Factors
Authors: Yu Yao , Sun Ruikai , Sun Yindong , Wu Jinyou , Zhu Wanying
Published: March 2022

Ports offer an effective way to facilitate the global economy. However, massive carbon emission during port operating aggravates the atmospheric pollution in port cities. Capturing characteristics of port carbon emission is vital to reduce GHG (greenhouse gas) in the maritime realm as well as to achieve China’s carbon neutral objective. In this work, an integrated framework is proposed for exploring the driving factors of China ports’ emissions combined with stochastic effects on population, affluence and technology regression (STIRPAT), Global Malmquist-Luenberger (GML) and multiple linear regression (MLR). The port efficiency is estimated for each port and the potential driving factors of carbon emission are explored. The results indicate that port carbon emissions have a strong connection with port throughput, productivity, containerization and intermodal transshipment. It is worth noting that the containerization ratio and port physical facility with fossil-free energy improvement have positively correlated with carbon emissions. However, the specific value of waterborne transshipment shows a complex impact on carbon dioxide emission as the ratio increases. The findings reveal that China port authorities need to improve containerization ratio and develop intermodal transportation; meanwhile, it is responsible for port authorities to update energy use and improve energy efficiency in ways to minimize the proportion of non-green energy consumption in accordance with optimizing port operation management including peak shaving and intelligent management systems under a new horizon of clean energy and automatic equipment.
Acute Effect of a Simultaneous Exercise and Cognitive Task on Executive Functions and Prefrontal Cortex Oxygenation in Healthy Older Adults
Authors: Pellegrini-Laplagne Manon , Dupuy Olivier , Sosner Philippe , Bosquet Laurent
Published: March 2022

The rapid increase in population aging and associated age-related cognitive decline requires identifying innovative and effective methods to prevent it. To manage this socio-economic challenge, physical, cognitive, and combined stimulations are proposed. The superiority of simultaneous training compared to passive control and physical training alone seems to be an efficient method, but very few studies assess the acute effect on executive function. This study aimed to investigate the acute effect of simultaneous physical and cognitive exercise on executive functions in healthy older adults, in comparison with either training alone. Seventeen healthy older adults performed three experimental conditions in randomized order: physical exercise, cognitive exercise, and simultaneous physical and cognitive exercise. The protocol involved a 30 min exercise duration at 60% of theoretical maximal heart rate or 30 min of cognitive exercise or both. Executive functions measured by the Stroop task and pre-frontal cortex oxygenation were assessed before and after the intervention. We found a main effect of time on executive function and all experimental condition seems to improve inhibition and flexibility scores (<0.05). We also found a decrease in cerebral oxygenation (Δ[HbO2]) in both hemispheres after each intervention in all cognitive performance assessed (p < 0.05). Simultaneous physical and cognitive exercise is as effective a method as either physical or cognitive exercise alone for improving executive function. The results of this study may have important clinical repercussions by allowing to optimize the interventions designed to maintain the cognitive health of older adults since simultaneous provide a time-efficient strategy to improve cognitive performance in older adults.
Immunomodulatory Properties of Immune Checkpoint Inhibitors—More than Boosting T-Cell Responses?
Authors: Kuske Michael , Haist Maximilian , Jung Thomas , Grabbe Stephan , Bros Matthias
Published: March 2022

The approval of immune checkpoint inhibitors (ICI) that serve to enhance effector T-cell anti-tumor responses has strongly improved success rates in the treatment of metastatic melanoma and other tumor types. The currently approved ICI constitute monoclonal antibodies blocking cytotoxic T-lymphocyte-associated protein (CTLA)-4 and anti-programmed cell death (PD)-1. By this, the T-cell-inhibitory CTLA-4/CD80/86 and PD-1/PD-1L/2L signaling axes are inhibited. This leads to sustained effector T-cell activity and circumvents the immune evasion of tumor cells, which frequently upregulate PD-L1 expression and modulate immune checkpoint molecule expression on leukocytes. As a result, profound clinical responses are observed in 40–60% of metastatic melanoma patients. Despite the pivotal role of T effector cells for triggering anti-tumor immunity, mounting evidence indicates that ICI efficacy may also be attributable to other cell types than T effector cells. In particular, emerging research has shown that ICI also impacts innate immune cells, such as myeloid cells, natural killer cells and innate lymphoid cells, which may amplify tumoricidal functions beyond triggering T effector cells, and thus improves clinical efficacy. Effects of ICI on non-T cells may additionally explain, in part, the character and extent of adverse effects associated with treatment. Deeper knowledge of these effects is required to further develop ICI treatment in terms of responsiveness of patients to treatment, to overcome resistance to ICI and to alleviate adverse effects. In this review we give an overview into the currently known immunomodulatory effects of ICI treatment in immune cell types other than the T cell compartment.
Discovery of Pre-Treatment FDG PET/CT-Derived Radiomics-Based Models for Predicting Outcome in Diffuse Large B-Cell Lymphoma
Authors: Frood Russell , Clark Matthew , Burton Cathy , Tsoumpas Charalampos , Frangi Alejandro F. , Gleeson Fergus , Patel Chirag , Scarsbrook Andrew F.
Published: March 2022

Background: Approximately 30% of patients with diffuse large B-cell lymphoma (DLBCL) will have recurrence. The aim of this study was to develop a radiomic based model derived from baseline PET/CT to predict 2-year event free survival (2-EFS). Methods: Patients with DLBCL treated with R-CHOP chemotherapy undergoing pre-treatment PET/CT between January 2008 and January 2018 were included. The dataset was split into training and internal unseen test sets (ratio 80:20). A logistic regression model using metabolic tumour volume (MTV) and six different machine learning classifiers created from clinical and radiomic features derived from the baseline PET/CT were trained and tuned using four-fold cross validation. The model with the highest mean validation receiver operator characteristic (ROC) curve area under the curve (AUC) was tested on the unseen test set. Results: 229 DLBCL patients met the inclusion criteria with 62 (27%) having 2-EFS events. The training cohort had 183 patients with 46 patients in the unseen test cohort. The model with the highest mean validation AUC combined clinical and radiomic features in a ridge regression model with a mean validation AUC of 0.75 ± 0.06 and a test AUC of 0.73. Conclusions: Radiomics based models demonstrate promise in predicting outcomes in DLBCL patients.
Alternative Splicing in Cancer and Immune Cells
Authors: Bernard Antoine , Boidot Romain , Végran Frédérique
Published: March 2022

Splicing is a phenomenon enabling the excision of introns from pre-mRNA to give rise to mature mRNA. All the 20,000 genes of the human genome are concerned by this mechanism. Nevertheless, it is estimated that the proteome is composed of more than 100,000 proteins. How to go from 20,000 genes to more than 100,000 proteins? Alternative splicing (AS) is in charge of this diversity of proteins. AS which is found in most of the cells of an organism, participates in normal cells and in particular in immune cells, in the regulation of cellular behavior. In cancer, AS is highly dysregulated and involved in almost all of the hallmarks that characterize tumor cells. In view of the close link that exists between tumors and the immune system, we present in this review the literature relating to alternative splicing and immunotherapy. We also provide a global but not exhaustive view of AS in the immune system and tumor cells linked to the events that can lead to AS dysregulation in tumors.
Endoscopic Ultrasound Plus Endoscopic Retrograde Cholangiopancreatography Based Tissue Sampling for Diagnosis of Proximal and Distal Biliary Stenosis Due to Cholangiocarcinoma: Results from a Retrospective Single-Center Study
Authors: Troncone Edoardo , Gadaleta Fabio , Paoluzi Omero Alessandro , Gesuale Cristina Maria , Formica Vincenzo , Morelli Cristina , Roselli Mario , Savino Luca , Palmieri Giampiero , Monteleone Giovanni , Del Vecchio Blanco Giovanna
Published: March 2022

Differentiating between benign and malignant biliary stenosis (BS) is challenging, where tissue diagnosis plays a crucial role. Endoscopic retrograde cholangiopancreatography (ERCP)-based tissue sampling and endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) or biopsy (FNB) are used to obtain tissue specimens from BS. The aim of this retrospective study was to evaluate the diagnostic yield of EUS-FNA/B plus ERCP with brushing or forceps biopsy in BS. All endoscopic procedures performed in patients with BS at our gastroenterology unit were reviewed. The gold standard for diagnosis was histopathology of surgical specimens or the progression of the malignancy at radiological or clinical follow-up. A total of 70 endoscopic procedures were performed in 51 patients with BS. Final endoscopic diagnosis was reached in 96% of the patients and was malignant in 61.7% and benign in 38.3% of cases. Sensitivity, specificity, and diagnostic accuracy were 73.9%, 100%, and 80%, respectively, for EUS-FNA/B; 66.7%, 100%, and 82.5% for ERCP; and 83.3%, 100%, and 87.5% for both procedures carried out in the same session. The combination of EUS and ERCP tissue sampling seems to increase diagnostic accuracy in defining the etiology of BS. Performing both procedures in a single session reduces the time required for diagnostic work-up and optimizes resources.
Use of Venetoclax in Patients with Relapsed or Refractory Acute Myeloid Leukemia: The PETHEMA Registry Experience
Authors: Labrador Jorge , Saiz-Rodríguez Miriam , de Miguel Dunia , de Laiglesia Almudena , Rodríguez-Medina Carlos , Vidriales María Belén , Pérez-Encinas Manuel , Sánchez-Sánchez María José , Cuello Rebeca , Roldán-Pérez Alicia , Vives Susana , Benzo-Callejo Gonzalo , Colorado Mercedes , García-Fortes María , Sayas María José , Olivier Carmen , Recio Isabel , Conde-Royo Diego , Bienert-García Álvaro , Vahi María , Muñoz-García Carmen , Seri-Merino Cristina , Tormo Mar , Vall-llovera Ferran , Foncillas María-Ángeles , Martínez-Cuadrón David , Sanz Miguel Ángel , Montesinos Pau
Published: March 2022

The effectiveness of venetoclax (VEN) in relapsed or refractory acute myeloid leukemia (RR-AML) has not been well established. This retrospective, multicenter, observational database studied the effectiveness of VEN in a cohort of 51 RR-AML patients and evaluated for predictors of response and overall survival (OS). The median age was 68 years, most were at high risk, 61% received ≥2 therapies for AML, 49% had received hypomethylating agents, and ECOG was ≥2 in 52%. Complete remission (CR) rate, including CR with incomplete hematological recovery (CRi), was 12.4%. Additionally, 10.4% experienced partial response (PR). The CR/CRi was higher in combination with azacitidine (AZA; 17.9%) than with decitabine (DEC; 6.7%) and low-dose cytarabine (LDAC; 0%). Mutated NPM1 was associated with increased CR/CRi. Median OS was 104 days (95% CI: 56–151). For the combination with AZA, DEC, and LDAC, median OS was 120 days, 104 days, and 69 days, respectively; p = 0.875. Treatment response and ECOG 0 influenced OS in a multivariate model. A total of 28% of patients required interruption of VEN because of toxicity. Our real-life series describes a marginal probability of CR/CRi and poor OS after VEN-based salvage. Patients included had very poor-risk features and were heavily pretreated. The small percentage of responders did not reach the median OS.
Enhanced Recovery Pathway in Lung Resection Surgery: Program Establishment and Results of a Cohort Study Encompassing 1243 Consecutive Patients
Authors: Nguyen Yen-Lan , Maiolino Elena , De Pauw Vincent , Prieto Mathilde , Mazzella Antonio , Peretout Jean-Baptiste , Dechartres Agnès , Baillard Christophe , Bobbio Antonio , Daffré Elisa , Alifano Marco
Published: March 2022

Introduction: In spite of increasing diffusion, Enhanced Recovery Pathways (ERP) have been scarcely assessed in large scale programs of lung cancer surgery. The aim of this study was auditing our practice. Methods: A two-step audit program was established: the first dealing with our initial ERP experience in patients undergoing non-extended anatomical segmentectomies and lobectomies, the second including all consecutive patients undergoing all kind of lung resections for NSCLC. The first step aimed at auditing results of ERP on occurrence of postoperative complications and at assessing which ERP components are associated with improved short-term outcomes. We also audited late results by assessing long-term survival of patients in the first step of our study. The second step aimed at auditing on large-scale short-term results of the ERP in a real-life setting. Results: Over a one-year period, 166 patients were included. The median number of ERP procedures per patient was three (IQR 3–4). No postoperative death occurred. The overall adverse events rate was 30%. In multivariate analyzes, the only element associated with reduced adverse postoperative events was chest tube withdrawal within POD2 (OR = 0.21, 95% CI (0.10–0.46)). The 1-, 3-, and 5-year survival rates were 97%, 86.1%, and 76.3%, respectively. In the second period, 1077 patients were included in our ERP; 11 patients died during the postoperative period or within 30 days of operation (1.02%). The overall postoperative adverse event rate was 30.3%, major complication occurring in 134 (12.4%), and minor ones in 192 (17.8%). Respiratory complications occurred in 64 (5.9%). Thoracoscore independently predicted postoperative death, the occurrence of complications (all-kind, minor, major, or respiratory ones). Conclusions: Compliance to ERP procedures and early chest tube removal are associated with reduced postoperative events in patients with lung resection surgery. In a large setting scale, ERP can be applied with satisfactory results in terms of mortality and morbidity. Thoracoscore is a useful tool in predicting mortality and postoperative adverse events.
Improving the Dyeing of Polypropylene by Surface Fluorination
Authors: Namie Masanari , Kim Jae-Ho , Yonezawa Susumu
Published: March 2022

The surface of polypropylene (PP) was modified with fluorine gas at 25 °C and 10–380 Torr for 1 h. The surface roughness of the fluorinated PP samples was approximately two times larger than that (5 nm) of the untreated sample. The results of Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy showed that the bonds (e.g., -C-C- and -CHx) derived from raw PP decreased and were converted into fluorinated bonds (e.g., -CFx) after surface fluorination. These fluorinated bonds showed higher electronegativity according to the zeta potential results. Fluorinated PP could be stained with the methylene blue basic dye because of the increased surface roughness and the negatively charged surface.
Changes in Soil-Phosphorus Fractions by Nitrogen and Phosphorus Fertilization in Korean Pine Plantation and Its Natural Forest
Authors: Hussain Anwaar , Chen Lixin , Jamil Muhammad Atif , Abid Kulsoom , Khan Kashif , Duan Wenbiao , Li Changzhun , Khan Attaullah
Published: March 2022

Phosphorus (P) is the restraining aspect in the forest ecosystem, particularly in temperate regions, and makes the ecosystem more liable to nitrogen (N)-derived acidification. However, it remains poorly understood how N and P fertilization together affects soil-P availability and other soil properties. To address this question, a factorial experiment was conducted with N and P additions under two forest ecosystems, i.e., Korean pine plantation (KPP) and natural Korean pine forest (NKPF). Both forests were divided in to three subplots and each subplot underwent four different treatments, i.e., C: control (no N and P addition), L: Low treatment (5 g N m−2 a−1 + 5 g P m−2 a−1), M: Medium treatment (15 g N m−2 a−1 + 10 g P m−2 a−1), and H: High treatment (30 g N m−2 a−1 + 20 g P m−2 a−1). Results revealed that the soil-P fractions changed during N and P fertilization over time although organic-P (Po) fractions were lower than inorganic-P (Pi) fractions. The residual P was increased overall, along with N deposition in soil. Soil organic carbon (SOC) was more present in NKPF soils as compared to KPP. Principal component analysis (PCA) indicated that at medium treatment there is maximum availability of P fractions as compared to other treatments in both forests, while high treatment showed some fixation of P in soils across both forests. Furthermore, SOC showed a negative correlation with residual P, while pH showed a positive correlation. Total N in soil showed a negative correlation with soil pH and residual P. Therefore, it is recommended that application of N and P at the rate of 15 g N m−2 a−1 + 10 g P m−2 a−1 is suitable in these two forest types to enhance P availability.
Effect of Simulated Combined N and P on Soil Acidity within Soil Aggregates in Natural and Planted Korean Pine Forest in Northeast China
Authors: Jamil Muhammad Atif , Hussain Anwaar , Duan Wenbiao , Chen Lixin , Khan Kashif , Abid Kulsoom , Li Changzhun , Guo Qiwen , Zarif Nowsherwan , Qu Meixue , Wang Yafei , Khan Attaullah
Published: March 2022

Globally, atmospheric nitrogen (N) deposition is rising, adversely impacting soil health, i.e., increasing soil acidity. While phosphorus (P) is the limiting element in the temperate environment and plays a key role in making the ecosystem more vulnerable to N-derived acidification. The impact of elevated N and P inputs on soil acidity and exchangeable base cations have been extensively studied; however, few studies have focused on these parameters, especially within various soil aggregate fractions in the temperate forest. In 2017, a field experiment was conducted under N and P additions with four soil aggregate fractions (>5 mm, 2–5 mm, 0.25–2 mm, and <0.25 mm) in two forests, i.e., the broad leave Korean pine forest (BKPF) and Korean pine plantation (KPP) in the Liangshui National Natural Reserves in Northeast China. Results showed that high NP addition decreases pH, base cations, Mg2+ Ca2+, and BS% and increases in Fe3+, Al3+, and E.A (effective acidity) in all four aggregate fractions, in descending order; overall concentration of the base cations is ranked as BKPF > KPP. Thus, soil acidification is primarily caused by a decrease in base cations, such as Ca2+ and Mg2+, and increase in exchangeable Fe3+ and Al3+ ions in large macro-aggregates and macro-aggregates, which leads to the depletion of soil nutrients. The initial pH value (5.69) in >5 mm soil aggregate was decreased to (5.4) under high fertilizer application, while a minimum value of 5.36 was observed in 0.25–2 mm aggregates under high fertilizer application. The same trend was observed in all aggregates because of decrease in base cations, which, in turn, affects the vitality and health of the forests.
Evolutionary and Association Analysis of Buffalo FABP Family Genes Reveal Their Potential Role in Milk Performance
Authors: Ye Tingzhu , Shaukat Aftab , Yang Lv , Chen Chao , Zhou Yang , Yang Liguo
Published: March 2022

The fatty acid-binding protein (FABP) family gene encode a group of proteins that affect long-chain fatty acid (LCFAs) trafficking and play a crucial function in the regulation of milk fat synthesis. Nevertheless, little is known regarding the identification of members, theevolutionary background, and functional characteristics of FABP genes in buffalo. In this study, in silico analysis was performed to identify the members of FABPs in buffalo. The results revealed that a total of 17 FABP genes were identified. Based on their phylogenetic relationships, these sequences clustered into five groups with similar motif patterns and gene structures. According to positive selection analyses, all duplicated gene pairs containing FABPs in buffalo had Ka/Ks (nonsynonymous/synonymous) ratios that were less than 1, suggesting that they were under purifying selection. Association analysis showed that one SNP in LOC102401361 was found significantly associated with buffalo milk yield. The expression levels of several FABPs in buffalo mammary epithelial cells were regulated by palmitic and stearic acid treatment. The findings of this study provide valuable information for further research on the role of FABPs in regulating buffalo milk synthesis.
Transcriptome Analysis Revealed Long Non-Coding RNAs Associated with mRNAs in Sheep Thyroid Gland under Different Photoperiods
Authors: Wang Wei , He Xiaoyun , Di Ran , Wang Xiangyu , Chu Mingxing
Published: March 2022

The thyroid gland is a vital endocrine organ involved in the reproduction of animals via the regulation of hormone synthesis and secretion. LncRNAs have been proven to play important roles in reproductive regulation; however, the associated mechanism in the thyroid gland has not been clarified. In this study, we investigated to identify photoperiod-induced lncRNAs and mRNAs in the thyroid gland in Sunite ewes by comparing the expression profiles of short photoperiod (SP) and long photoperiods (LP). A total of 41,088 lncRNAs were identified in the thyroid gland through RNA-Seq. Functional analysis of differentially expressed lncRNAs using the R package revealed that reproductive hormone- and photoperiod response-related pathways, including the prolactin signaling, cAMP signaling, and circadian rhythm pathways, were significantly enriched. An mRNA-lncRNA interaction analysis suggested that the lncRNA LOC1056153S88 trans targets ARG2 and CCNB3, and the lncRNA LOC105607004 trans targets DMXL2, both of these might be involved in seasonal sheep breeding reproduction. Together, these results will provide resources for further studies on seasonal reproduction in sheep.
Association between Gastrointestinal Diseases and Migraine
Authors: Kim Jemin , Lee Sujin , Rhew Kiyon
Published: March 2022

Migraine is a common disease worldwide, and recent studies showed that the incidence of migraine was increased in patients with gastrointestinal (GI) diseases. In addition, preclinical evidence suggested a bidirectional relationship between the GI nervous system and the central nervous system called the gut–brain axis. This study aimed to determine the association between several high-prevalence GI diseases and migraine. Patients diagnosed with migraine or GI diseases were classified as the patient group at least twice a year. We included peptic ulcer disease, dyspepsia, inflammatory bowel disease, irritable bowel syndrome, and gastroesophageal disease as GI diseases. A total of 781,115 patients from the HIRA dataset were included in the study. The prevalence of migraine was about 3.5 times higher in patients with one or more GI diseases after adjusting for age, gender, and insurance type (adjusted odds ratio (ORadj = 3.46, 95% CI: 3.30–3.63, p < 0.001). In addition, the prevalence of migraine was increased as the number of comorbid GI diseases increased. The prevalence of GI disease was also higher in patients with medication for migraine, both preventive and acute treatment, compared to patients with either acute preventive or acute treatment. There was a statistically significant association between the prevalence of GI diseases and migraine, and the higher the number of accompanying GI diseases, the higher the correlation was in patients using both preventive and acute treatment drugs for migraine.
Device-Based Movement Behaviors, Executive Function, and Academic Skills among African American Children with ADHD and Disruptive Behavior Disorders
Authors: Santiago-Rodríguez María Enid , Ramer Jared D. , Marquez David X. , Frazier Stacy L. , Davis Catherine L. , Bustamante Eduardo E.
Published: March 2022

Background: Physical activity (PA) has been identified as a promising intervention to improve executive function (EF) and reduce ADHD symptoms in children. Few African American children with ADHD and Disruptive Behavior Disorders (DBDs) from families with low incomes are represented in this literature. The purpose of this study is to test the relationships between PA and sedentary time (ST), and EF and academic skills among African American children with ADHD and DBD from low-income families. Methods: Children (n = 23, 6–13 years old) wore an ActiGraph for one week to measure PA and ST. EF was measured through parent report and direct neuropsychological tests. Academic skills were measured with the Curriculum-Based Measurement System. Bivariate correlations tested relationships between PA, ST, EF, and academic skills. Results: A significant correlation was observed between vigorous PA time and parent reported EF (r = −0.46, p = 0.040). Light PA and moderate PA were not related to EF or academic skills, and neither was ST. Conclusions: Vigorous PA may prove useful as an adjunct treatment to improve EF in African American children with ADHD and DBD in low-income neighborhoods. Research using experimental and longitudinal designs, and examining qualitative features of PA experiences, will be critical for understanding relationships between PA, academic skills, and EF in this population.
Incidence of Surgical Site Infection and Use of Antibiotics among Patients Who Underwent Caesarean Section and Herniorrhaphy at a Regional Referral Hospital, Sierra Leone
Authors: Carshon-Marsh Ronald , Squire James Sylvester , Kamara Kadijatu Nabbie , Sargsyan Aelita , Delamou Alexandre , Camara Bienvenu Salim , Manzi Marcel , Guth Jamie Ann , Khogali Mohamed Ahmed , Reid Anthony , Kenneh Sartie
Published: March 2022

Surgical site infections (SSIs) are common postoperative complications. Surgical antibiotic prophylaxis (SAP) can prevent the occurrence of SSIs if administered appropriately. We carried out a retrospective cohort study to determine the incidence of SSIs and assess whether SAP were administered according to WHO guidelines for Caesarean section (CS) and herniorrhaphy patients in Bo regional government hospital from November 2019 to October 2020. The analysis included 681 patients (599 CSs and 82 herniorrhaphies). Overall, the SSI rate was 6.7% among all patients, and 7.5% and 1.2% among CS patients and herniorrhaphy patients, respectively. SAP was administered preoperatively in 85% of CS and 70% of herniorrhaphy patients. Postoperative antibiotics were prescribed to 85% of CS and 100% of herniorrhaphy patients. Ampicillin, metronidazole, and amoxicillin were the most commonly used antibiotics. The relatively low rate of SSIs observed in this study is probably due to improved infection prevention and control (IPC) measures following the Ebola outbreak and the current COVID-19 pandemic. A good compliance rate with WHO guidelines for preoperative SAP was observed. However, there was a high use of postoperative antibiotics, which is not in line with WHO guidelines. Recommendations were made to ensure the appropriate administration of SAP and reduce unnecessary use of antibiotics.