bluuebunny/crossref_metadata_2025 huggingface dataset:
IL CONTROLLO POLITICO DELL'ECONOMIA: GLI STUDI SUL CICLO POLITICO-ECONOMICO
Authors: Radaelli Claudio Maria
Published: May 2019

Introduzione

Lo studio degli aspetti politici dei fenomeni economici ha acquisito, nel corso degli ultimi due decenni, un ruolo di crescente importanza nei lavori di politologi ed economisti appartenenti alla «scuola» della political economy, generando grandi aspettative, ma anche qualche cocente delusione. Le aspettative sono sicuramente elevate, se Stephen Weatherford (1988, 99) ha potuto sostenere che «i modelli del ciclo economico-politico sono diventati la nuova ortodossia negli studi accademici sul processo di formazione della politica economica». Le delusioni discendono invece dalla mancata rilevazione di regolarità empiriche dotate di una sufficiente stabilità, dall'esiguità di controlli comparati delle ipotesi, da un apparato concettuale che contempla tratti estremamente ed eccessivamente stilizzati del sistema politico.
Restriction fragment length polymorphisms in plant breeding and genetics
Authors: Prince James P. , Tanksley Steven D.
Published: May 2019

Synopsis

The usefulness of restriction fragment length polymorphisms (RFLPs) in plant breeding and genetics is discussed, with particular emphasis on tagging genes, map-based cloning, the assessment of genetic variability and distances, and comparative genome mapping.

The Department of Plant Breeding and Biometry has currently established tight linkages between RFLPs and more than 20 genes of economic importance. Approximately half of these genes confer resistance to major pathogens including nematodes, bacteria, fungi, and viruses. Other genes tagged are involved in various aspects of crop quality.

Locating genes with respect to DNA markers on an RFLP map provides a starting point for cloning the genes by chromosome walking. This strategy is currently being pursued for three disease-resistance genes that have been placed on the tomato RFLP map;Pto(resistance toPseudomonas syringae),Mi(resistance to root-knot nemotodes) andTm2a(resistance to tobacco mosaic virus). Further discussion will include the construction of a yeast artificial chromosome library and the collection of additional DNA markers in the regions of interest through RAPD analysis of nearly isogenic lines.

The assessment of genetic variability and fingerprinting varieties based on RFLP data will be briefly discussed.

Comparative genome mapping in the family Solanaceae has allowed the relationships among tomato, potato, and pepper to be unravelled. Tomato and potato share a near perfect conservation of gene order throughout their genomes. In contrast, while pepper shares most of its single copy DNA with tomato and potato, the order of these markers is highly rearranged compared with the other two species.
Splicing of plant pre-mRNAs
Authors: Simpson Craig G. , Simpson Gordon G. , Clark Gillian , Leader David J. , Vaux Petra , Guerineau F. , Waugh Robbie , Brown John W. S.
Published: May 2019

Synopsis

Pre-messenger RNA (pre-mRNA) splicing or the removal of introns from pre-mRNA transcripts is a key process in the maturation of mRNA. This process requires the assembly of a large complex of RNA and protein molecules, called the splicosome, on the pre-mRNA transcripts. Molecular and biochemical analyses of plant intron sequence and structure and of the components of the plant spliceosome are providing information on the mechanism of intron recognition and splice site selection in both monocoty-ledonous and dicotyledonous plants. This knowledge will help in gaining an understanding of phenomena such as the difference in splicing between monocotyledonous and dictoyledonous plants, the enhancement of gene expression brought about by the presence of some introns and alternative splicing. The importance of introns and pre-mRNA splicing to accurate and regulated gene expression, therefore, is of direct relevance to transgene expression and genetic manipulation.
Control of insect pests by plant genetic engineering
Authors: Gatehouse Angharad M. R. , Hilder Vaughan A. , Gatehouse John A.
Published: May 2019

Crop protection against pests and diseases is of prime importance and plays a major role in agricultural production both in the Developed and Developing parts of the world.

Although chemical pesticides have been in use for a long time it is only since the Second World War that a very heavy and almost exclusive reliance has been placed upon their use. This, in many cases, has resulted in the rapid build-up of resistance by insect pests to such compounds, as is illustrated by the rapidly developed resistance to the organochloride insecticides by the cotton bollworm, Heliothis virescens. Indeed, there are many examples of resistance in a major pest being observed within the first year of field use (Metcalf 1986). In some cases the indiscriminate application of pesticides has exacerbated the problem of insect herbivory where elimination of a wide range of predatory species along with the primary pests has resulted in secondary pests becoming primary pests themselves with even more devastating effects (Heinrichs & Mochida 1983).
Genetic engineering of virus resistance: a successful genetical alchemy
Authors: Harrison B. D.
Published: May 2019

Synopsis

Some of the most successful early applications of genetic engineering in crop improvement have been in the production of virus-resistant plants. This has been achieved not by the transfer of naturally occurring resistance genes from one plant species or variety to another but by transformation with novel resistance genes based on nucleotide sequences derived from the viruses themselves or from virus-associated nucleic acids. Transformation of plants with a DNA copy of the particle protein gene of viruses that have positive-sense single-stranded RNA genomes typically confers resistance to infection with the homologous and closely related viruses. Transformation with a gene that is transcribed to produce a benign viral satellite RNA can confer virus-specific tolerance of infection. In addition, recent work with viral poly-merase gene-related sequences offers much promise, and research is active on other strategies such as the use of virus-specific ribozymes.

Already the field trialling of plants incorporating transgenic virus resistance has begun, with encouraging results, and effects on virus spread are being studied. Deployment strategies for the resistant plants must now be devised and the conjectural hazards of growing them assessed. Genetically engineered virus resistance promises to make a major contribution to the control of plant virus diseases by non-chemical methods.
Genetic engineering for stress tolerance in the Triticeae
Authors: Forster B. P.
Published: May 2019

Synopsis

Genetic variation within a crop species is often limited and restricts improvement by conventional breeding methods. This is particularly true for environmental stresses, both biotic and abiotic. Wild relatives of crop plants, however, provide a rich source of novel variation which can be introduced into the crop. Many alien genes for biotic stress resistance have already been introduced into crops; in contrast, the genetic control of abiotic stress tolerance is poorly understood. Genetic engineering of abiotic stress tolerance in the Triticeae is the main subject discussed here with particular reference to salt tolerance in wheat and barley. Methods of alien gene transfer, including locating tolerance genes and restructuring chromosomes, are described. One of the major limitations in transferring genes for stress tolerance is the lack of good tests for resistance or tolerance which is largely due to the fact the physiological mechanisms involved are not fully understood. Genetic markers provide a new opportunity of detecting chromosome segments carrying desired genes easily and efficiently, and these will become increasingly important as the genetic maps of crop species are expanded. Although many stress genes have been located to specific chromosomes, and some have been mapped intra-chromosomally and their dominance relations determined, there is a great lack of knowledge of the control of these genes at the molecular level. Molecular studies of this type are difficult, but it is anticipated that the limitations will be overcome in the near future.
Patents for plants and genes under the European Patent Convention
Authors: Byrne Noel
Published: May 2019

Synopsis

The cost of patenting an invention should be incurred only where the patent is likely to give the inventor an economic or a tactical advantage. Where it is practicable, secrecy may be preferable to patenting. If an advantage from patenting can be envisaged, then in Western Europe the inventor can apply either for a European patent under the European Patent Convention or for a national patent. The inventor in plant biotechnology faces a ban on patenting certain inventions, including plant varieties and essentially biological processes for the production of plants. But since this ban is interpreted strictly, there are opportunities for patenting what at first glance might seem not patentable. A patent application must give a written description of the invention that is complete enough for a skilled person to reproduce it. The inventor may be required to supplement the description in a patent specification for a biotechnological invention, by depositing a sample of relevant biological materials. A European patent is treated as a national patent in the country for which it was granted. Since a patent may be invalidated in enforcement proceedings, patenting may turn out to have been a costly mistake.
From venom to toxin to drug?
Authors: Harvey Alan L.
Published: May 2019

Synopsis:

Venoms are complex mixtures of many different components, whereas a toxin is a single pure compound whose activity can be specified. Toxins often have novel, highly specific activities. Studies on toxins open the way to design therapeutically useful molecules based on the structural information obtained from the toxins.

An example of successful drug development from a component of a snake venom is that of the inhibitors of angiotensin-converting enzyme (ACE). The first ACE inhibitors were developed from work on peptides isolated from the Brazilian arrowhead viperBothrops jaracusathat prolonged the action of bradykinin. The venom components blocked the enzyme that inactivated bradykinin; the same enzymeactivatedthe precursor of the vasoconstrictor hormone angiotensin. Hence, a valuable new type of therapy was established by developing the leads provided by the natural toxin.

Dendrotoxins are small proteins from mamba venoms that block rapidly activating K+channels in neurones. There are possibilities that dendrotoxin could be the basis for drug design. A small analogue that mimicked the activity of dendrotoxin in the central nervous system might boost the activity of certain neuronal pathways. Potentially, such a compound might be able to restore some of the function of systems damaged by progressive neurodegenerative diseases. Although dendrotoxin-like compounds would not be a cure for these diseases, they may provide temporary relief from symptoms.

Conversely, compounds with the specificity of dendrotoxin but with ability to activate K+channels, rather than block them, may be a novel way of reducing abnormal electrical activity in the brain. Hence, they may form the basis of a new type of anticonvulsant drug for epilepsies.

Recent work at Strathclyde has concentrated on defining the structure-activity relationships of the naturally occurring dendrotoxins and on synthesising small analogues of the postulated ‘active site’. Preliminary results are encouraging, and it is hoped to go from green mamba venom to dendrotoxin to therapeutically useful drugs.
Protein evolution and its analytical potential
Authors: Dufton Mark J.
Published: May 2019

Synopsis:

With the recent advances in gene technology, a substantial premium has been placed on the ability to predict protein structure and mechanism from sequence data alone. This is because the direct experimental approaches are more time and labour intensive, and progress is slower. One area of theoretical investigation which has a clear potential to assist in predictive exercises is the natural evolution of protein structure and sequence.

Some aspects of protein evolution, such as the fact that homology of sequence often denotes common ancestry, are routinely considered in predicting three-dimensional structure and mechanism. However, there are other aspects to this natural process which are either not realised or are not appreciated as potential analytical tools.

This article introduces the different ways protein evolution can be investigated and indicates developing techniques as well as those already well established.
Iron chelating agents with clinical potential
Authors: Hider R. C. , Singh S. , Porter J. B.
Published: May 2019

Synopsis:

Iron is a critically important metal for a wide variety of cellular events. The element holds this central position by virtue of its facile redox chemistry and the high affinity of both redox states (iron II and iron III) for oxygen. These same properties also render iron toxic when levels exceed the normal binding capacity of the cell. As a result of this potential toxicity, selective iron chelators are finding an important role in the treatment of iron overload associated with many forms of thalassaemia. In addition, they appear to have potential in treating situations where a local increase in iron concentration causes an unfavourable pathology, for instance, in reperfused tissue (heart disease and stroke) and in Parkinsonian brain. There is also evidence that iron chelators may minimise the toxicity of paraquat and the side effects of bleomycin and doxorubicin.

Non-haem iron enzymes can also be inhibited by iron chelators and consequently such enzymes as ribonucleotide reductase and lipoxygenase can be selectively inhibited. Such inhibitory action is being investigated for the treatment of malaria, neoplastic disease, psoriasis and asthma.

Recent developments in these areas are discussed in the present overview.
Cell proliferation and oxidative stress: basis for anticancer drugs
Authors: Burdon Roy H.
Published: May 2019

Synopsis:

A wide variety of normal and malignant mammalian cells, as well as inflammatory cells, release extracellular active oxygen species such as superoxide and hydrogen peroxide. Both these species at low levels can stimulate growth and growth responses in a range of normal and malignant cell types. In order to assess the significance of such findings, superoxide dismutase and catalase were added exogenously to the culture medium of hamster (BHK-21) and rat (208F) fibroblasts (non-transformed or oncogene transformed). This resulted in a reduction of cell proliferation and increased cellular uptake of trypan blue stain, suggesting that superoxide and/or hydrogen peroxide may have important roles as extracellular ‘messengers’ promoting cell proliferation and maintaining cell viability. Superoxide dismutase mimics, like superoxide dismutase itself, are also cytostatic towards these cells and provide a basis for the development of tumour-specific antiproliferative drugs.
Diabetic Neuropathy: Models, Mechanisms and Mayhem
Authors: Thomas P.K.
Published: May 2019

Rational treatment of diabetic polyneuropathy depends upon establishing its cause, which is at present unknown. A number of animal models of diabetes have been examined and although abnormalities are detectable in the peripheral nervous system they do not duplicate the degenerative neuropathy encountered in the human. The relevance of these abnormalities is therefore uncertain, although they may reflect the earlier changes in man. For human neuropathy, it is likely that vascular lesions or an abnormal susceptibility to mechanical injury are responsible for focal neuropathies. The evidence that ischaemia and hypoxia are responsible for the diffuse sensory neuropathy and autonomic polyneuropathy is still equivocal and it is often difficult to establish whether the vascular changes are primary or secondary. Metabolic explanations, such as sorbitol accumulation in nerve, have not so far been adequately validated by responses to treatment. The manifestations of diabetic neuropathy are complex and a single explanation should not be sought.
Lesions of the Tunica Media in Traumatic Rupture of Vertebral Arteries: Histologic and Biochemical Studies
Authors: Pollanen M.S. , Deck J.H.N. , Boutilier L. , Davidson G.
Published: May 2019

Discontinuous non-circumferential lesions of tunica media were observed in four cases of traumatic rupture of the vertebral artery. We hypothesize that these lesions were due to mechanical disruption of smooth muscle cells and the liberation of catabolic enzymes with subsequent degradation of the arterial media. To test this hypothesis, healthy vertebral arteries were incubated with crude extracts of bovine smooth muscle cytosol in attempt to reproduce the histological changes of the arterial media in traumatized vertebral arteries. We observed cytosol-induced degradation of tunica media, characterized by pallor of staining with the Masson’s Trichrome method, which was due to catabolic enzyme activity that was effectively inhibited by heat inactivation of the cytosol. The cytosol-induced tinctorial changes were similar to the lesions of the tunica media in naturally-occurring cases of traumatic vertebral artery rupture. We conclude that although vertebral arteries can be ruptured by physical distortion alone, associated lesions of the tunica media are due to in situ trauma-associated release of heat-labile catabolic enzymes.
Concerning the Mechanism of Recovery in Stroke Hemiphegia
Authors: Fisher C. Miller
Published: May 2019

Two patients with pure motor hemiplegia were regaining strength in the affected limbs when a pure motor stroke developed on the opposite side. At the same time as the new hemiplegia appeared, the recovering side became re-paralyzed, suggesting that activity in the contralateral corticospinal tract had participated in the recovery process. Pathological studies were confirmatory. The literature pertaining to contralateral motor compensation is reviewed.
Prevalence of Multiple Sclerosis in Barrhead County, Alberta, Canada
Authors: Warren Sharon , Warren K.G.
Published: May 2019

A prevalence study of multiple sclerosis (MS) was carried out in the town of Barrhead and surrounding county of Barrhead, in Alberta, Canada. The prevalence rate for clinically probable/definite multiple sclerosis on January 1, 1990 was 196/100,000. The average annual incidence rates for patients living in the area at onset were 1.31/100,000 for 1950–59, 4.97/100,000 for 1960–69, 3.77/100,000 for 1970–79, and 4.22/100,000 for 1980–89. Fifty per cent of the patients were relapsing-remitting. Sixty per cent were still walking without assistance. The female-to-male ratio was 1:1. Mean current age, age at onset and duration of illness were 49, 27 and 22 years respectively. The majority of patients (40%) experienced multiple symptom onset. Fifty per cent were of single ethnic origin (either British or German); the rest were predominantly North European combinations. Forty per cent of patients reported another MS relative. MS had affected the work status of 60% of the patients, 15% of whom were confined to an extended care centre.
Precise Bathymetry as a Step Towards Producing Bathymetric Electronic Navigational Charts for Comparative (Terrain Reference) Navigation
Authors: Stateczny Andrzej , Gronska-Sledz Daria , Motyl Weronika
Published: May 2019

Bathymetric Electronic Navigational Charts (bENCs) contain only bathymetry data and can be used in applications such as underwater positioning, dredging and piloting. According to International Hydrographic Organization (IHO) standard S-57, Electronic Navigational Charts (ENCs) contain depth information with pure density of depth contours. Typical depth contours encoded by Hydrographic Offices are limited to 2, 5, 10 and 20 m. Availability of more depth contours in bENCs would allow the visualisation of a safety contour which is closer to users' specific needs, especially in restricted waters such as ports, lakes and rivers. Another problem is non – Global Navigation Satellite System (GNSS) Unmanned Underwater Vehicle (UUV) navigation. bENCs could be used as reference data for UUV comparative navigation. This is called terrain reference navigation. This article presents the results from bathymetric data processing that was performed to convert data contained in bENCs into a reference for underwater comparative navigation. We use data obtained using a multibeam echo sounder to produce depth data with a horizontal spacing of 0·10 m that is suitable for use in restricted waters. The experimental data was collected in and around the Port of Gdansk, Poland.
Forecasting Item Movement with Scan Data: Box-Jenkins Results
Authors: Eastwood David B. , Gray Morgan D. , Brooker John R.
Published: May 2019

Preliminary forecasts using the Box-Jenkins methodology for supermarket scan data for ground beef and roast item movement are described. The functional form and the accuracy of the forecasts vary by product. Results suggest that further analyses incorporating price and advertising may increase the accuracy of the forecasts.
Integrated Assessment of Environmental Effects from Agricultural Production
Authors: Lee John G. , Lovejoy Stephen B.
Published: May 2019

Agriculture's impact on the environment is a complex research problem. A challenge to future economic research is to account for the interrelationship between agricultural production activities, soil productivity, erosion, and water quality. It will become increasingly important to determine not only the economic consequences, but also the environmental effectiveness of alternative policies aimed at improving resource use and quality. The application of biophysical simulation models to environmental quality problems provides a means to better understand the complex interaction between agricultural production and environmental quality.
Comparative Economics of Alternative Agricultural Production Systems: A Review
Authors: Fox Glenn , Weersink Alfons , Sarwar Ghulam , Duff Scott , Deen Bill
Published: May 2019

The agricultural policy agenda in the United States, Canada, and in Western Europe has been increasingly influenced by concerns for the sustainability of agricultural production systems. National, state, and provincial governments in North America are becoming increasingly sensitive to the environmental and human-health risks associated with current modes of agricultural production and policy actions, including restrictions on the use of certain agricultural chemicals and inducements to encourage the use of alternative production practices. Many restrictions and inducements have been undertaken or are currently under consideration in many jurisdictions.
Quality Changes and Limited Marketing Season Effects on the Demand for Fresh Blueberries
Authors: Hoelper Antonia L. , Marra Michele C.
Published: May 2019

This study examines the notion that fresh-fruit prices follow a time trend separate from the effect of seasonal supply changes over the marketing season. In particular, quality changes and a limited marketing season are hypothesized to contribute to the seasonal changes in demand. The empirical results support these hypotheses for the Boston fresh-blueberry market.
Molecular mechanisms relating to amino acid regulation of protein synthesis
Authors: Cao Yangchun , Liu Shimin , Liu Kai , Abbasi Imtiaz Hussain Raja , Cai Chuanjiang , Yao Junhu
Published: May 2019

Some amino acids (AA) act through several signalling pathways and mechanisms to mediate the control of gene expression at the translation level, and the regulation occurs, specifically, on the initiation and the signalling pathways for translation. The translation of mRNA to protein synthesis proceeds through the steps of initiation and elongation, and AA act as important feed-forward activators that are involved in many pathways, such as the sensing and the transportation of AA by cells, in these steps in many tissues of mammals. For the translation, phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) is a critical molecule that controls the translation initiation and its functions can be regulated by some AA. Another control point in the mRNA binding step in the translation initiation is at the regulation by mammalian target of rapamycin, which requires a change of phosphorylation status of ribosomal protein S6. In fact, the change of phosphorylation status of ribosomal protein S6 might be involved in global protein synthesis. The present review summarises recent work on the molecular mechanisms of the regulation of protein synthesis by AA and highlights new findings.
Catastrophic ongoing decline in Cambodia’s Bengal Florican Houbaropsis bengalensis population
Authors: MAHOOD SIMON P. , HONG CHAMNAN , VIRAK SON , SUM PHEARUN , GARNETT STEPHEN T.
Published: May 2019

In 2013 a prediction was made that the South-East Asian subspecies of Bengal Florican Houbaropsis bengalensis blandini would be extinct within 10 years. In 2018 we conducted a survey in the Tonle Sap floodplain, Cambodia, of the last population of Bengal Florican in South-East Asia. We found that the rate of decline in displaying males was 55% over five years, a decline comparable to that recorded between 2005–2007 and 2012. The estimated number of displaying males in 2018 was 104 (95% CI: 89–117), down from 216 (156–275) in 2012. We also conducted surveys by flushing birds in the non-breeding season, which indicated that the sex ratio of males to females is 3:1. We therefore estimate that the total population of adult Bengal Floricans in Cambodia in 2018 was 138 (119–156), making H. b. blandini the most threatened bustard taxon. The number of sites that support displaying male Bengal Floricans was reduced from 10 to four between 2012 and 2018. Between 2012 and 2018 we monitored numbers of displaying males in most years at the sites that support 80% of the total population. The only site where numbers of birds are stable is Stoung-Chikraeng Bengal Florican Conservation Area, where there were 44 (25–63) displaying males in 2018. This is the only site that has an ongoing NGO-government conservation programme. Our data indicate that Bengal Floricans are lost from sites when the area of grassland falls below 25 km2. We found evidence that displaying male Bengal Floricans abandon display territories when grassland is lost, this also creates hope that they may disperse and could colonise newly created habitat. All remaining sites that support Bengal Floricans in Cambodia are imperilled and we outline what must be done to reduce the possibility that H. b. blandini will be extinct by 2023.
Elimination of arrhythmogenesis after subtotal resection of congenital cardiac fibroma: a case report
Authors: Nabeshima Taisuke , Sato Seiichi , Nakayashiro Mami
Published: May 2019

Subtotal tumour resection is used to treat infants with congenital cardiac fibroma and medication-resistant ventricular arrhythmias; however, complete elimination of arrhythmogenic substrates has been unclear. A 4-month-old male infant with congenital cardiac fibroma and ventricular fibrillation underwent subtotal tumour resection and implantable cardioverter-defibrillator implantation. Five years later, angiography revealed impending compression of the left coronary artery. Elimination of the arrhythmogenic substrate was confirmed and the device was removed successfully.
First steps to a clinical research unit for developmental research in paediatric cardiology: conception and progress of the LEADER project (Long Term Early Development Research) in CHD
Authors: Pfitzer Constanze , Ferentzi Hannah , Rosenthal Lisa-Maria , Kramer Peter , Berger Felix , Schmitt Katharina R. L.
Published: May 2019

Objective:

We developed the Long-term Early Development Research (LEADER) project to investigate the development of children with CHD and/or after cardiopulmonary resuscitation. Both populations are at risk for delays in motor, cognitive, and language development. However, few studies to date have investigated the longitudinal development in these children.

Methods:

To establish a clinical research unit, we planned three studies: a cross-sectional study in children after cardiopulmonary resuscitation (LEADER-REA Pilot Study), a longitudinal study in children after cardiopulmonary resuscitation, with a focus on evaluating various biomarkers as predictors for developmental outcome (LEADER-CPR study), and a longitudinal study in children with ventricular septal defect, tetralogy of Fallot, or transposition of the great arteries after cardiac surgery (LEADER-CHD study).

Results:

Implementation of all three LEADER studies was successful and study protocols were conducted as planned. Findings from the LEADER-REA Pilot study have been recently published and data collection for both prospective trials is ongoing. Descriptive analysis of the first 20 assessments of the LEADER-CHD study showed no severe deficits in overall cognitive, motor, and language developments in the children.

Conclusions:

Children with CHD and/or after cardiopulmonary resuscitation are at risk for developmental delay. Therefore, a detailed developmental assessment is necessary as a pre-requisite for individual developmental support. Our LEADER project has been shown to be feasible in a clinical setting and is the first step towards the establishment of a clinical research unit in our clinic with a focus on longitudinal research.
The problem of non-truth-conditional, lower-level modifiers: a Functional Discourse Grammar solution
Authors: KEIZER EVELIEN
Published: May 2019

This article discusses two groups of prosodically and linearly integrated modifiers: evaluative (‘subject-oriented’) adverbs (e.g.cleverly,stupidlyandrecklessly) and non-restrictive prenominal modifiers (e.g.oldas inmy old mother). What these two groups of elements have in common is the rather puzzling fact that both are (or have been analysed as) relatively low-level modifiers (i.e. as part of the proposition), while at the same time being non-truth-conditional/non-restrictive (suggesting they are non-propositional). In this article it is argued that although there is indeed compelling syntactic evidence that these elements modify a relatively low layer in the clause (proposition or lower), this need not be incompatible with their non-truth-conditional/non-restrictive status. Using the theory of Functional Discourse Grammar (FDG), an analysis is proposed in which these elements are not part of the proposition expressed by the clause in which they occur, but instead form part of a separate proposition, in which they function as non-verbal predicates taking a specific layer of analysis (e.g. a proposition, State-of-Affairs, entity or property) as their argument. The analysis proposed not only reconciles the specific semantic and syntactic properties of the modifiers in question, but also reveals the similarities between the two groups of modifiers discussed.
MARGINALIZED YET MOBILIZED
Authors: McGregor Alecia J. , Bogart Laura M. , Higgins-Biddle Molly , Strolovitch Dara Z. , Ojikutu Bisola
Published: May 2019

Both African American and LGBT voters can prove pivotal in electoral outcomes, but we know little about civic participation among Black LGBT people. Although decades of research on political participation has made it almost an article of faith that members of dominant groups (such as White people and individuals of higher socioeconomic status) vote at higher rates than their less privileged counterparts, recent work has suggested that there are circumstances under which members of marginalized groups might participate at higher rates. Some of this research suggests that political participation might also increase when groups perceive elections as particularly threatening. We argue that when such threats are faced by marginalized groups, the concern to protect hard-earned rights can activate a sense of what we call “political hypervigilance,” and that such effects may be particularly pronounced among members of intersectionally-marginalized groups such as LGBT African Americans. To test this theory, we use original data from the 2016 National Survey on HIV in the Black Community, a nationally-representative survey of Black Americans, to explore the relationship among same-sex sexual behavior, attitudes toward LGBT people, and respondent voting intentions in the 2016 presidential election. We find that respondents who reported having engaged in same-sex sexual behavior were strongly and significantly more likely to say they “definitely will vote” compared to respondents who reported no same-sex sexual behavior. More favorable views of LGBT individuals and issues (marriage equality) were also associated with greater intention to vote. We argue that these high rates provide preliminary evidence that political hypervigilance can, in fact, lead to increased political engagement among members of marginalized groups.
United States Heat Wave Frequency and Arctic Ocean Marginal Sea Ice Variability
Authors: Budikova Dagmar , Ford Trent W. , Ballinger Thomas J.
Published: May 2019

Recent studies point to a significant rise in the number of summer extreme weather events that correspond with the presence of amplified, quasistationary midtropospheric planetary waves, weakened atmospheric circulation in the Northern Hemisphere, and coincide with reduced summer Arctic sea ice cover. This study explores potential connections between 1979 and 2016 summer heat wave frequency across the USA and regional Arctic sea ice extent (SIE) in various Arctic basins. Most notable SIE interannual relationships exist across the southern Plains and southeastern US during low Hudson Bay summer SIE. Locally increased frequencies of summer heat waves coincide with unseasonably warm conditions developed and sustained by the presence of an omega blocking pattern situated over the southern US throughout summer. The block appears following anomalous atmospheric warming and reduced mean zonal winds observed throughout spring (March–May) over northeastern Canada, the northwestern Atlantic basin, and Greenland. Spring preconditioning of summer ice melt is favored by the presence of strong negative phase of the North Atlantic Oscillation and positive Greenland Blocking Index. Summer synoptic flow related to Hudson Bay ice melt over North America appears to be influenced by the background state of atmospheric variability, namely, the positive phase of the Atlantic Multidecadal Oscillation. Antecedent local humidity, soil moisture, and precipitation conditions are shown to influence the “flavor” of the heat waves, which are more likely to be oppressive in the southeastern US and extreme across the southern Plains during summers experiencing low Hudson SIE.
Annual Cycle of Gravity Wave Activity Derived From a High‐Resolution Martian General Circulation Model
Authors: Kuroda Takeshi , Yiğit Erdal , Medvedev Alexander S.
Published: May 2019

The paper presents results of simulations with a high‐resolution (equivalent to ∼67‐km grid size) Martian general circulation model (MGCM) from the surface up to the mesosphere for a full Martian year. The obtained climatology of the small‐scale disturbances can serve as a proxy for gravity waves (GWs) that are largely not resolved by MGCMs with conventional grid resolution and thus have to be parameterized. GW activity varies greatly with season and geographical location, which contradicts with the constant in space and time sources in the lower atmosphere adopted by GW parameterizations employed by coarse‐grid MGCMs. In particular, lower‐atmospheric GW activity is smaller in polar regions of the troposphere throughout all seasons, and the intensity is larger in southern spring and summer and in winter hemisphere at both solstices. In the mesosphere, the peak of GW activity shifts toward middle and high latitudes, and the interhemispheric symmetry is much larger compared to the lower atmosphere. The detailed climatology created in this study can be used for prescribing sources of GWs in parameterizations utilized by MGCMs as well as for validating the parameterizations in the middle and upper atmosphere.
Introducing the New Editor-in-Chief of JGR: Planets
Authors: Mont�si Laurent
Published: May 2019

Find out about the person taking the helm of JGR: Planets and his plans for taking the journal forward in the coming years.
Detecting Carbonates on the Surface of Mars
Authors: Underwood Emily
Published: May 2019

A new study shows how a warm, wet climate weathered rocks on early Mars.
Interplanetary Shock Parameters Near Jupiter's Orbit
Authors: Echer E.
Published: May 2019

Fast interplanetary shocks occurrence, their parameters, and drivers near Jupiter's orbit are determined in this paper. It was found that 70% of the fast shocks are forward (FS) and 30% are reverse (RS). Interplanetary coronal mass ejection‐driven FS occur more frequently in all solar cycle phases except in the declining phase, when corotating interaction region‐driven shocks predominate. Most of the shocks were quasi‐perpendicularly (65° to 70°) propagating relative to the ambient interplanetary magnetic field. The average shock magnetosonic Mach number is slightly higher for FS (2.6) than for RS (2.4), which in turn are stronger than shocks near 1 and 10 AU reported in previous works. This occurs because of the full development of corotating interaction region shocks and higher occurrence of strong interplanetary coronal mass ejections near 5 AU and that the magnetosonic speed at 5 AU has only 60% of its value at 1 AU.
Self‐Similarity of ICME Flux Ropes: Observations by Radially Aligned Spacecraft in the Inner Heliosphere
Authors: Good S. W. , Kilpua E. K. J. , LaMoury A. T. , Forsyth R. J. , Eastwood J. P. , Möstl C.
Published: May 2019

Interplanetary coronal mass ejections (ICMEs) are a significant feature of the heliospheric environment and the primary cause of adverse space weather at the Earth. ICME propagation and the evolution of ICME magnetic field structure during propagation are still not fully understood. We analyze the magnetic field structures of 18 ICME magnetic flux ropes observed by radially aligned spacecraft in the inner heliosphere. Similarity in the underlying flux rope structures is determined through the application of a simple technique that maps the magnetic field profile from one spacecraft to the other. In many cases, the flux ropes show very strong underlying similarities at the different spacecraft. The mapping technique reveals similarities that are not readily apparent in the unmapped data and is a useful tool when determining whether magnetic field time series observed at different spacecraft are associated with the same ICME. Lundquist fitting has been applied to the flux ropes, and the rope orientations have been determined; macroscale differences in the profiles at the aligned spacecraft may be ascribed to differences in flux rope orientation. Assuming that the same region of the ICME was observed by the aligned spacecraft in each case, the fitting indicates some weak tendency for the rope axes to reduce in inclination relative to the solar equatorial plane and to align with the solar east‐west direction with heliocentric distance.
Effect of Unidirectional Vertical Wind Shear on Tropical Cyclone Intensity Change—Lower‐Layer Shear Versus Upper‐Layer Shear
Authors: Fu Hao , Wang Yuqing , Riemer Michael , Li Qingqing
Published: May 2019

In this study, a quadruply nested, nonhydrostatic tropical cyclone (TC) model is used to investigate how the structure and intensity of a mature TC respond differently to imposed lower‐layer and upper‐layer unidirectional environmental vertical wind shears (VWSs). Results show that TC intensity in both cases decrease shortly after the VWS is imposed but with quite different subsequent evolutions. The TC weakens much more rapidly for a relatively long period in the upper‐layer shear than in the lower‐layer shear, which is found to be related to the stronger storm‐relative asymmetric flow in the middle‐upper troposphere and the larger vertical vortex tilt in the former than in the latter. The stronger storm‐relative flow in the former imposes a greater ventilation of the warm core in the middle‐upper troposphere, leading to a more significant weakening of the storm. The storm in the lower‐layer shear only weakens initially after the VWS is imposed but then experiences a quasi periodic intensity oscillation with a period of about 24 hr. This quasi periodic behavior is found to be closely related to the boundary layer thermodynamic “discharge/recharge” mechanism associated with the activity of shear‐induced outer spiral rainbands. There is no significant intensity oscillation for the storm embedded in the upper‐layer shear, even though outer spiral rainbands develop quasi periodically also. The boundary layer inflow is very weak in that case and the low equivalent potential temperature air induced by downdrafts in outer spiral rainbands therefore cannot penetrate into the inner core but remains in the outer region.
Evaluating the Extent of North Atlantic Deep Water and the Mean Atlantic δ13C From Statistical Reconstructions
Authors: Bengtson Shannon A. , Meissner Katrin J. , Menviel Laurie , Sisson Scott A. , Wilkin John
Published: May 2019

Benthic δ13C is often used to infer past changes in ocean circulation, though the interpretation of this proxy is difficult due to data scarcity and uncertainties. We present two methods for reconstructing the δ13C signal of North Atlantic Deep Water (NADW) and Antarctic Bottom Water and calculating the average oceanic δ13C values for the Atlantic Ocean based on δ13C from benthic foraminifera. The two simple statistical models are described and tested for the Holocene and the Last Glacial Maximum. The first statistical model consists of regressions of the δ13C data, which vary quadratically with depth and linearly with latitude. It differentiates between two regions, one for NADW and another for Antarctic Bottom Water. The second method consists of a hyperbolic tangent regression, which is bound asymptotically by the water mass source region averages (end‐members). To test the robustness of the statistical models, two isotope‐enabled climate models, the UVic ESCM and LOVECLIM, are sampled randomly, generating “pseudoproxies.” These are then used for testing the accuracy of the statistical models against the complete climate model δ13C outputs. We quantitatively compare the average δ13C and NADW depth against the original climate model outputs. We find that both statistical approaches are robust, regardless of the spatial distribution of the pseudoproxies, with the quadratic approach better able to capture the shape of NADW δ13C signal. Hence, this method can potentially be applied to different δ13C data sets to evaluate past changes in NADW.
CAD/CAM for scalable nanomanufacturing: A network-based system for hybrid 3D printing
Authors: Yoon Hae-Sung , Lee Hyun-Taek , Jang Ki-Hwan , Kim Chung-Soo , Park Hyunseo , Kim Dae-Wook , Lee Kunwoo , Min Sangkee , Ahn Sung-Hoon
Published: May 2019

Micro- and nano-structuring have been highlighted over several decades in both science and engineering fields. In addition to continuous efforts in fabrication techniques, investigations in scalable nanomanufacturing have been pursued to achieve reduced feature size, fewer constraints in terms of materials and dimensional complexity, as well as improved process throughput. In this study, based on recent micro-/nanoscale fabrication processes, characteristics and key requirements for computer-aided design and manufacturing (CAD/CAM) systems for scalable nanomanufacturing were investigated. Requirements include a process knowledge database, standardized processing, active communication, adaptive interpolation, a consistent coordinate system, and management of peripheral devices. For scalable nanomanufacturing, it is important to consider the flexibility and expandability of each process, because hybrid and bridging processes represent effective ways to expand process capabilities. As an example, we describe a novel CAD/CAM system for hybrid three-dimensional (3D) printing at the nanoscale. This novel hybrid process was developed by bridging aerodynamically focused nanoparticle printing, focused ion beam milling, micromachining, and spin-coating processes. The system developed can print a full 3D structure using various inorganic materials, with a minimum process scale of 50 nm. The most obvious difference versus CAD/CAM at ‘conventional’ scales is that our system was developed based on a network to promote communication between users and process operators. With the network-based system, it is also possible to narrow the gap among different processes/resources. We anticipate that this approach can contribute to the development of CAD/CAM for scalable nanomanufacturing and a wide range of hybrid processes.
Combination therapy with BYL719 and LEE011 is synergistic and causes a greater suppression of p-S6 in triple negative breast cancer
Authors: Yuan Yuan , Wen Wei , Yost Susan E. , Xing Quanhua , Yan Jin , Han Ernest S. , Mortimer Joanne , Yim John H.
Published: May 2019

A third of patients with triple negative breast cancer (TNBC) have relapsed disease within 2–5 years from initial diagnosis, leaving an unmet need for therapeutic targets. TNBC frequently harbors alterations of the PI3K/AKT/mTOR pathway, but single agent PI3K/AKT/mTOR inhibitors have not shown marked efficacy. In this study, we investigated a strategy to improve efficacy of PI3K-α inhibitor BYL719 (alpelisib) in TNBC. While BYL719 is effective at inhibiting cell proliferation in T47D, a triple positive cell line, it had limited activity in TNBC. This may be partially due to persistent phosphorylation of RB, and incomplete inhibition of p-S6 in TNBC, since the inhibitory effect of BYL719 on p-RB and p-S6 was significantly reduced in TNBC compared to T47D cells. Addition of the CDK4/6 inhibitor LEE011 to BYL719 caused a simultaneous reduction of p-RB and p-S6, and a more complete inhibition of p-S6, leading to decreased expression of the pro-survival protein MCL-1, an induction of apoptosis, and an enhanced reduction of tumor growth in a PDX model of TNBC. These findings suggest that inhibition of p-RB and p-S6 is important for an effective response to the treatment of TNBC, and provides a strong rationale for clinical development of combination therapy with BYL719 and LEE011 for treatment of metastatic TNBC with intact RB.

Presentation: This study was presented in part as an abstract at the 2016 San Antonio Breast Cancer Symposium (P3-03-15) and the 2018 Cancer Research and Targeted Therapy in London.