bluuebunny/crossref_metadata_2025 huggingface dataset:
Caterpillar-Induced Volatile Emissions in Cotton: The Relative Importance of Damage and Insect-Derived Factors
Authors: Arce Carla M. , Besomi Gaia , Glauser Gaétan , Turlings Ted C. J.
Published: August 2021

In response to herbivore attack, plants release large amounts of volatiles that can serve as attractants for the natural enemies of the attacking herbivores. Such responses are typically triggered by damage- and insect-associated factors. Cotton plants are somewhat peculiar because they release specific blends of volatiles in two waves in response to caterpillar attack. They first emit constitutively stored volatile compounds, and after about 24 h a second wave that includes various de novo synthesized compounds. The relative importance of damage-associated and insect associated-factors in this induction of cotton volatile emissions is not yet fully clear. We evaluated how cotton plants respond to mechanical damage and to the application of the oral secretion from the generalist lepidopteran pest Spodoptera exigua, by measuring the local and systemic emissions of volatile compounds from their leaves. Our results confirm that cotton plants respond to damage-associated molecular patterns (DAMPs) as well as to herbivore-associated molecular patterns (HAMPs) present in the caterpillars’ oral secretion. Interestingly, a stronger response was observed for cotton plants that were treated with oral secretion from cotton-fed caterpillars than those fed on maize. We tested the possibility that volicitin, a common fatty acid-derived elicitor in caterpillar regurgitant plays a role in this difference. Volicitin and volicitin-like compounds were detected in equal amounts in the oral secretion of S. exigua fed on either cotton or maize leaves. We conclude that other elicitors must be involved. The identification of these eliciting cues is expected to contribute to the development of novel strategies to enhance the resistance of cotton plants to insect pests.
Rice Potassium Transporter OsHAK8 Mediates K+ Uptake and Translocation in Response to Low K+ Stress
Authors: Wang Xiaohui , Li Junfeng , Li Fei , Pan Yu , Cai Dan , Mao Dandan , Chen Liangbi , Luan Sheng
Published: August 2021

Potassium (K+) levels in the soil often limit plant growth and development. As a result, crop production largely relies on the heavy use of chemical fertilizers, presenting a challenging problem in sustainable agriculture. To breed crops with higher K+-use efficiency (KUE), we must learn how K+ is acquired from the soil by the root system and transported to the rest of the plant through K+ transporters. In this study, we identified the function of the rice K+ transporter OsHAK8, whose expression level is downregulated in response to low-K+ stress. When OsHAK8 was disrupted by CRISPR/Cas9-mediated mutagenesis, Oshak8 mutant plants showed stunted growth, especially under low-K+ conditions. Ion content analyses indicated that K+ uptake and root-to-shoot K+ transport were significantly impaired in Oshak8 mutants under low-K+ conditions. As the OsHAK8 gene was broadly expressed in different cell types in the roots and its protein was targeted to the plasma membrane, we propose that OsHAK8 serves as a major transporter for both uptake and root-to-shoot translocation in rice plants.
Egocentric and Allocentric Reference Frames Can Flexibly Support Contextual Cueing
Authors: Zheng Lei , Dobroschke Jan-Gabriel , Pollmann Stefan
Published: August 2021

We investigated if contextual cueing can be guided by egocentric and allocentric reference frames. Combinations of search configurations and external frame orientations were learned during a training phase. In Experiment 1, either the frame orientation or the configuration was rotated, thereby disrupting either the allocentric or egocentric and allocentric predictions of the target location. Contextual cueing survived both of these manipulations, suggesting that it can overcome interference from both reference frames. In contrast, when changed orientations of the external frame became valid predictors of the target location in Experiment 2, we observed contextual cueing as long as one reference frame was predictive of the target location, but contextual cueing was eliminated when both reference frames were invalid. Thus, search guidance in repeated contexts can be supported by both egocentric and allocentric reference frames as long as they contain valid information about the search goal.
Musicians as “Makers in Society”: A Conceptual Foundation for Contemporary Professional Higher Music Education
Authors: Gaunt Helena , Duffy Celia , Coric Ana , González Delgado Isabel R. , Messas Linda , Pryimenko Oleksandr , Sveidahl Henrik
Published: August 2021

This paper considers the purpose, values and principles underpinning higher music education (HME) as one of the performing arts in a context of turbulent global change. Recognising complex challenges and opportunities in this field, HME is addressed from dual perspectives: educating the next generations of professional musicians, and higher music institutions’ (HMEIs) engagement in society. The paper has a particular focus on the sector within HME that is dedicated to intensive practical craft training for performers, composers, programmers, producers, managers, and teachers. We argue that there is an urgent need for fresh orientating frameworks through which to navigate HME’s development. We examine concepts such as artistic citizenship, social responsibility and civic mission increasingly perceived to be relevant to the sector, and we explore their connexions to concepts of artistic excellence, imagination and creativity, and musical heritage. We identify apparent dichotomies of value within contemporary HME, including between intrinsic and instrumental purpose in the arts, cultural heritage, and new work, artistic imagination and entrepreneurship, and we argue that creative tensions between what have hitherto easily been perceived as opposing concepts or competing priorities need to be embraced. To support our argument we draw on the particular ethnomusicological concept of “musicking,” and we look toward a partnering of artistic and social values in order to enable HME to respond dynamically to societal need, and to continue to engage with the depth and integrity of established musical traditions and their craft. Based on this discussion we propose a conceptual foundation: the “musician as a maker in society,” in which developing vision as a musician in society, underpinned on the one hand by immersion in musical artistry and on the other hand sustained practical experience of connecting and engaging with communities, offers invaluable preparation for and transition into professional life. We propose that this idea, connecting societal and artistic vision and practise, is equally essential for HMEIs as it is for musicians, and sits at the heart of the roles they evolve within their local communities and wider society.
Applying Machine Learning Approaches to Suicide Prediction Using Healthcare Data: Overview and Future Directions
Authors: Boudreaux Edwin D. , Rundensteiner Elke , Liu Feifan , Wang Bo , Larkin Celine , Agu Emmanuel , Ghosh Samiran , Semeter Joshua , Simon Gregory , Davis-Martin Rachel E.
Published: August 2021

Objective: Early identification of individuals who are at risk for suicide is crucial in supporting suicide prevention. Machine learning is emerging as a promising approach to support this objective. Machine learning is broadly defined as a set of mathematical models and computational algorithms designed to automatically learn complex patterns between predictors and outcomes from example data, without being explicitly programmed to do so. The model's performance continuously improves over time by learning from newly available data.

Method: This concept paper explores how machine learning approaches applied to healthcare data obtained from electronic health records, including billing and claims data, can advance our ability to accurately predict future suicidal behavior.

Results: We provide a general overview of machine learning concepts, summarize exemplar studies, describe continued challenges, and propose innovative research directions.

Conclusion: Machine learning has potential for improving estimation of suicide risk, yet important challenges and opportunities remain. Further research can focus on incorporating evolving methods for addressing data imbalances, understanding factors that affect generalizability across samples and healthcare systems, expanding the richness of the data, leveraging newer machine learning approaches, and developing automatic learning systems.
Urban Green Infrastructure for Poverty Alleviation: Evidence Synthesis and Conceptual Considerations
Authors: Shackleton Charlie M.
Published: August 2021

The multiple benefits of urban green infrastructure (UGI) that support sustainable cities are increasingly acknowledged, and yet the bulk of research over the past decade or so has focused on only a small subset of the numerous benefits, notably recreation, physical and mental health, and regulating services. In contrast, there is very little information on the contribution of UGI to several of the other Sustainable Development Goals (SDGs), and in particular SDG 1 of reducing poverty, despite the pervasiveness of poverty globally. This paper considers the diverse direct and indirect ways in which UGI can contribute to poverty alleviation, drawing on the limited evidence from various regions of the world. The direct links between UGI and poverty alleviation is via three means, namely provision of (1) consumptive or provisioning goods such as wild foods and firewood, (2) employment in UGI development, maintenance, and restoration, and (3) land for urban agriculture, income generation and dwelling. There are also a number of indirect links such as cash savings, improved physical and mental health, improved social networks, improved educational outcomes, and regulation of potential natural disasters. However, the commonly unequal distribution of UGI within and between cities means that the poverty alleviation potential and benefits are inequitably distributed, often against those who are most in need of them, i.e., the urban poor. This demands greater attention to promoting the equitable distribution and quality of UGI and mainstreaming of UGI into poverty reduction strategies and programmes and vice versa, as well as greater examination of the links between UGI and poverty alleviation in a greater range of contexts.
Healthy Meal, Happy Brain: How Diet Affects Brain Functioning
Authors: Ahmad Fatima , Hasan Hiba , Abdelhady Samar , Fakih Walaa , Osman Nawara , Shaito Abdullah , Kobeissy Firas
Published: August 2021

Do you know that the foods you eat impact your health? Most importantly, what you eat can have negative effects on the most complex organ in your body: your brain! Amazingly, the food you eat affects neurons, which are the major cells of the brain. In the brain, an unhealthy diet that is rich in fats and sugars causes inflammation of neurons and inhibits the formation of new neurons. This can affect the way the brain works and contribute to brain disorders like depression. On the other hand, a diet that contains healthy nutrients, such as omega-3 fatty acids, is beneficial for brain health. Such a diet improves the formation of neurons and leads to improved thinking, attention, and memory. In sum, a healthy diet makes the brain happy, so we should all pay attention to what we eat.
Goldilocks And The San Francisco Estuary: How Scientists Determine When Water Is “Just Right”
Authors: Martinez Morgan N. , Flynn Theodore M.
Published: August 2021

Have you ever accidentally gotten seawater in your mouth? You probably spit it out because it tasted so bad, right? Even though it looks clear, water in rivers, bays, and oceans contains lots of other things besides H2O, including some things that are not healthy for people or animals! To determine the quality of a body of water, scientists measure the temperature and how much salt, sediment, and nutrients are present in that water. Too much or too little of these things, caused by pollution, floods, or droughts, might be bad for the health of the environment. Just like the porridge in the story of Goldilocks and the Three Bears, water quality must be “just right” to be healthy for the living things that need it.
Isolation and Genetic Characterization of Canine Parvovirus in a Malayan Tiger
Authors: Nur-Farahiyah Ahmad Nadzri , Kumar Kiven , Yasmin Abd Rahaman , Omar Abdul Rahman , Camalxaman Siti Nazrina
Published: August 2021

Naïve Felidae in the wild may harbor infectious viruses of importance due to cross-species transmission between the domesticated animals or human–wildlife contact. However, limited information is available on virus shedding or viremia in the captive wild felids, especially in Malaysia. Four infectious viruses of cat, feline herpesvirus (FHV), feline calicivirus (FCV), canine distemper virus (CDV), and canine parvovirus (CPV), were screened in leopards, feral cats, and tigers in Malaysia based on virus isolation in Crandell-Rees feline kidney (CRFK) cells, PCR/RT-PCR, and whole-genome sequencing analysis of the positive isolate. From a total of 36 sera collected, 11 samples showed three consecutive cytopathic effects in the cell culture and were subjected to PCR using specific primers for FHV, FCV, CDV, and CPV. Only one sample from a Malayan tiger was detected positive for CPV. The entire viral genome of CPV (UPM-CPV15/P. tigris jacksoni; GenBank Accession number MW380384) was amplified using the Sanger sequencing approach. Genome sequencing of the isolate revealed 99.13, 98.65, and 98.40% close similarity to CPV-31, CPV-d Cornell #320, and CPV-15 strains, respectively, and classified as CPV-2a. Time-scaled Bayesian Maximum Clade Credibility tree for the non-structural (NS) genes of CPV showed a close relationship to the isolates CPV-CN SD6_2014 and KSU7-SD_2004 from China and USA, respectively, while the capsid gene showed the same ancestor as the FPV-BJ04 strain from China. The higher evolution rate of the capsid protein (CP) (VP 1 and VP2) [1.649 × 10−5 (95% HPD: 7.626 × 10−3 to 7.440 × 10−3)] as compared to the NS gene [1.203 × 10−4 (95% HPD: 6.663 × 10−3 to 6.593 × 10−3)] was observed in the CPV from this study, and fairly higher than other parvovirus species from the Protoparvovirus genus. Genome sequencing of the isolated CPV from a Malayan tiger in the present study provides valuable information about the genomic characteristics of captive wild felids, which may add information on the presence of CPV in species other than dogs.
Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses
Authors: Hopster Klaus , Hurcombe Samuel D. A.
Published: August 2021

Bioreactance is the continuous analysis of transthoracic voltage variation in response to an applied high frequency transthoracic current and was recently introduced for non-invasive cardiac output measurement (NICOM). We evaluated NICOM compared to thermodilution (TD) in adult horses. Six healthy horses were used for this prospective, blinded, experimental study. Cardiac output (CO) measurements were performed simultaneously using TD and the bioreactance method. Different cardiac output scenarios were established using xylazine (0.5 mg/kg IV) and dobutamine (1.5–3 mcg/kg/min). Statistical analysis was performed by calculating the concordance rate, performing a regression analysis, Pearson correlation, and Bland Altman. The TD-based CO and NICOM values were highly correlated for low, normal and high CO values with an overall correlation coefficient. A 4-quadrant plot showed an 89% rate of concordance. The linear regression calculated a relationship between NICOM and TDCO of Y = 0.4874 · X + 0.5936. For the corrected Bland Altman agreement, the mean bias and lower/upper limits of agreement were −0.26 and −3.88 to 3.41 L/min, respectively. Compared to TD, bioreactance- based NICOM showed good accuracy at induced low, normal, and high CO states in normal horses. Future studies performed under more clinical conditions will show if this monitor can help to assess hemodynamic status and guide therapy in horses in ICU settings and under general anesthesia.
Social Determinants of Narcotics Use Susceptibility among School-Attending Adolescents in Bissau, Guinea-Bissau: A Cross-Sectional Analysis
Authors: Bollom Jon Edmund , Baldé Aladje , Jandi Zeca , Boiro Hamadou , Einarsdóttir Jónína , Gunnlaugsson Geir
Published: August 2021

Balanced medical and criminal justice approaches addressing determinants of alcohol and other drugs (AOD) use are central to achieving the United Nations Sustainable Development Goals 3 and 16. However, data on AOD use in resource-poor settings are characterised by relative paucity and anecdote. This study aimed to describe and analyse AOD use susceptibility and its determinants among school-attending adolescents in the capital Bissau, Guinea-Bissau. Survey data were collected through a locally adapted Planet Youth questionnaire in June 2017 across 16 schools in Bissau. The 2039-strong sample was selected through a multi-stage, random cluster process. Participants’ lifetime alcohol use was 27.3%, smoking 10.8%, and cannabis use 3.6%. In each instance, the ‘15 years and above’ age bracket was the most common initiation period, signifying increased instigation in later adolescence. Subsequent Varimax Principal Component Analysis (PCA) of 312 variables captured data-driven models of AOD use susceptibility, implying imitated, polydrug use among initiates. Linear regression analysis revealed drinking, group violence, male gender, school dismissal and relationship breakdown as explanatory variables. Overlapping predictive variables suggest singular interventions may pre-empt myriad antisocial behaviours. PCA offers alternatives to singular, potentially myopic quantifications of drug use. PCA facilitates the creation of context-sensitive composite variables, enabling the identification of related outcome behaviours relevant to studies’ sociocultural settings.
PSMA Theranostics: Science and Practice
Authors: Mokoala Kgomotso , Lawal Ismaheel , Lengana Thabo , Kgatle Mankgopo , Giesel Frederik L. , Vorster Mariza , Sathekge Mike
Published: August 2021

Prostate cancer (PCa) causes significant morbidity and mortality in men globally. While localized PCa may be managed with curative intent by surgery and/or radiation therapy, the management of advanced hormone resistant metastatic disease (mCRPC) is more challenging. Theranostics is a principle based on the ability to use an organ specific ligand and label it to both a diagnostic and a therapeutic agent. The overexpression of prostate specific membrane antigen (PSMA) on prostate cancer cells creates a unique opportunity for development of targeted radionuclide therapy. The use of both beta and alpha emitting particles has shown great success. Several clinical trials have been initiated assessing the efficacy and safety profile of these radionuclide agents. The results are encouraging with PSMA directed radioligand therapy performing well in patients who have exhausted all other standard treatment options. Future studies need to assess the timing of introduction of these radionuclide therapies in the management schema of mCRPC. Drugs or therapies are not without side effects and targeted radionuclide therapies presents a new set of toxicities including xerostomia and myelosuppression. New therapeutic strategies are being explored to improve outcomes while keeping toxicities to a minimum. This review aims to look at the various PSMA labelled tracers that form part of the theragnostic approach and subsequently delve into the progress made in the area of radionuclide therapy.
The Critical Role of Growth Factors in Gastric Ulcer Healing: The Cellular and Molecular Mechanisms and Potential Clinical Implications
Authors: Tarnawski Andrzej S. , Ahluwalia Amrita
Published: August 2021

In this article we review the cellular and molecular mechanisms of gastric ulcer healing. A gastric ulcer (GU) is a deep defect in the gastric wall penetrating through the entire mucosa and the muscularis mucosae. GU healing is a regeneration process that encompasses cell dedifferentiation, proliferation, migration, re-epithelialization, formation of granulation tissue, angiogenesis, vasculogenesis, interactions between various cells and the matrix, and tissue remodeling, all resulting in scar formation. All these events are controlled by cytokines and growth factors (e.g., EGF, TGFα, IGF-1, HGF, bFGF, TGFβ, NGF, VEGF, angiopoietins) and transcription factors activated by tissue injury. These growth factors bind to their receptors and trigger cell proliferation, migration, and survival pathways through Ras, MAPK, PI3K/Akt, PLC-γ, and Rho/Rac/actin signaling. The triggers for the activation of these growth factors are tissue injury and hypoxia. EGF, its receptor, IGF-1, HGF, and COX-2 are important for epithelial cell proliferation, migration, re-epithelialization, and gastric gland reconstruction. VEGF, angiopoietins, bFGF, and NGF are crucial for blood vessel regeneration in GU scars. The serum response factor (SRF) is essential for VEGF-induced angiogenesis, re-epithelialization, and blood vessel and muscle restoration. Local therapy with cDNA of human recombinant VEGF165 in combination with angiopoietin1, or with the NGF protein, dramatically accelerates GU healing and improves the quality of mucosal restoration within ulcer scars. The future directions for accelerating and improving healing include local gene and protein therapies with growth factors, their combinations, and the use of stem cells and tissue engineering.
Mitochondrial Ferritin: Its Role in Physiological and Pathological Conditions
Authors: Levi Sonia , Ripamonti Maddalena , Dardi Marko , Cozzi Anna , Santambrogio Paolo
Published: August 2021

In 2001, a new type of human ferritin was identified by searching for homologous sequences to H-ferritin in the human genome. After the demonstration that this ferritin is located specifically in the mitochondrion, it was called mitochondrial ferritin. Studies on the properties of this new type of ferritin have been limited by its very high homology with the cytosolic H-ferritin, which is expressed at higher levels in cells. This great similarity made it difficult to obtain specific antibodies against the mitochondrial ferritin devoid of cross-reactivity with cytosolic ferritin. Thus, the knowledge of the physiological role of mitochondrial ferritin is still incomplete despite 20 years of research. In this review, we summarize the literature on mitochondrial ferritin expression regulation and its physical and biochemical properties, with particular attention paid to the differences with cytosolic ferritin and its role in physiological condition. Until now, there has been no evidence that the alteration of the mitochondrial ferritin gene is causative of any disorder; however, the identified association of the mitochondrial ferritin with some disorders is discussed.
UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin
Authors: Peris-Moreno Dulce , Malige Mélodie , Claustre Agnès , Armani Andrea , Coudy-Gandilhon Cécile , Deval Christiane , Béchet Daniel , Fafournoux Pierre , Sandri Marco , Combaret Lydie , Taillandier Daniel , Polge Cécile
Published: August 2021

The ubiquitin proteasome system (UPS) is the main player of skeletal muscle wasting, a common characteristic of many diseases (cancer, etc.) that negatively impacts treatment and life prognosis. Within the UPS, the E3 ligase MuRF1/TRIM63 targets for degradation several myofibrillar proteins, including the main contractile proteins alpha-actin and myosin heavy chain (MHC). We previously identified five E2 ubiquitin-conjugating enzymes interacting with MuRF1, including UBE2L3/UbcH7, that exhibited a high affinity for MuRF1 (KD = 50 nM). Here, we report a main effect of UBE2L3 on alpha-actin and MHC degradation in catabolic C2C12 myotubes. Consistently UBE2L3 knockdown in Tibialis anterior induced hypertrophy in dexamethasone (Dex)-treated mice, whereas overexpression worsened the muscle atrophy of Dex-treated mice. Using combined interactomic approaches, we also characterized the interactions between MuRF1 and its substrates alpha-actin and MHC and found that MuRF1 preferentially binds to filamentous F-actin (KD = 46.7 nM) over monomeric G-actin (KD = 450 nM). By contrast with actin that did not alter MuRF1–UBE2L3 affinity, binding of MHC to MuRF1 (KD = 8 nM) impeded UBE2L3 binding, suggesting that differential interactions prevail with MuRF1 depending on both the substrate and the E2. Our data suggest that UBE2L3 regulates contractile proteins levels and skeletal muscle atrophy.
A Hybrid Analysis-Based Approach to Android Malware Family Classification
Authors: Ding Chao , Luktarhan Nurbol , Lu Bei , Zhang Wenhui
Published: August 2021

With the popularity of Android, malware detection and family classification have also become a research focus. Many excellent methods have been proposed by previous authors, but static and dynamic analyses inevitably require complex processes. A hybrid analysis method for detecting Android malware and classifying malware families is presented in this paper, and is partially optimized for multiple-feature data. For static analysis, we use permissions and intent as static features and use three feature selection methods to form a subset of three candidate features. Compared with various models, including k-nearest neighbors and random forest, random forest is the best, with a detection rate of 95.04%, while the chi-square test is the best feature selection method. After using feature selection to explore the critical static features contained in this dataset, we analyzed a subset of important features to gain more insight into the malware. In a dynamic analysis based on network traffic, unlike those that focus on a one-way flow of traffic and work on HTTP protocols and transport layer protocols, we focused on sessions and retained protocol layers. The Res7LSTM model is then used to further classify the malicious and partially benign samples detected in the static detection. The experimental results show that our approach can not only work with fewer static features and guarantee sufficient accuracy, but also improve the detection rate of Android malware family classification from 71.48% in previous work to 99% when cutting the traffic in terms of the sessions and protocols of all layers.
A Novel Faulty Phase Selection Method for Single-Phase-to-Ground Fault in Distribution System Based on Transient Current Similarity Measurement
Authors: Tang Yaojing , Chang Yongle , Tang Jinrui , Xu Bin , Ye Mingkang , Yang Hongbo
Published: August 2021

In modern electrical power distribution systems, the effective operation of inverter-based arc suppression devices relies on the accuracy of faulty phase selection. In the traditional methods of faulty phase selection for single-phase-to-ground faults (SPGs), power frequency-based amplitude and phase characteristics are used to identify the faulty phase. In the field, when a high-resistance SPG occurs in the system, traditional methods are difficult for accurately identifying the faulty phase because of the weak fault components and complicated process. A novel realizable and effective method of faulty phase selection based on transient current similarity measurements is presented when SPGs occur in resonantly grounded distribution systems in this paper. An optimized Hausdorff distance matrix (MOHD) is proposed and constructed by the transient currents of three phases’ similarity measurements within a certain time window of our method. This MOHD is used to select the sampling time window adaptively, which allows the proposed method to be applied to any scale of distribution systems. Firstly, when a SPG occurs, the expressions for the transient phase current mutation in the faulty and sound phases are analyzed. Then, the sampling process is segmented into several selection units (SUs) to form the MOHD-based faulty phase selection method. Additionally, the Hausdorff distance algorithm (HD) is used to calculate the waveform similarities of the transient phase current mutation among the three phases to form the HD-based faulty phase selection method. Finally, a practical resonant grounded distribution system is modeled in PSCAD/EMTDC, and the effectiveness and performance of the proposed method is compared and verified under different fault resistances, fault inception angles, system topologies, sampling time windows and rates of data missing.
Combining Sufficiency, Efficiency and Flexibility to Achieve Positive Energy Districts Targets
Authors: Erba Silvia , Pagliano Lorenzo
Published: August 2021

Energy efficiency, generation from renewable sources and more recently energy flexibility are key elements of present sustainability policies. However, we are beginning to see a recognition of the need to couple technological solutions with lifestyle and behavioral changes, sometimes labeled under the term “sufficiency”. Appropriate policies and design principles are necessary to enable sufficiency options, which in turn reveal that there is a bidirectional influence between the building and the district/city level. In this context, the authors discuss how city and building re-design should be implemented combining energy efficiency, flexibility, production from renewables and sufficiency options for achieving a positive energy balance at the district level even within the constraints of dense cities. Based on a review of recent advances, the paper provides a matrix of interactions between building and district design for use by building designers and city planners. It also compares possible scenarios implementing different strategies at the building and urban level in a case study, in order to evaluate the effect of the proposed integrated approach on the energy balance at yearly and seasonal time scales and on land take.
Paleovegetational Reconstruction and Implications on Formation of Oil Shale and Coal in the Lower Cretaceous Laoheishan Basin (NE China): Evidence from Palynology and Terpenoid Biomarkers
Authors: Song Yu , Zhu Kai , Xu Yinbo , Meng Qingtao , Liu Zhaojun , Sun Pingchang , Ye Xiang
Published: August 2021

In some cases, the oil shale deposited in shallow lakes may be genetically associated with the coal-bearing successions. Although paleovegetation is an important controlling factor for the formation of oil shale- and coal-bearing successions, few studies have focused on their joint characterization. In this study, a total of twenty-one oil shale and coal samples were collected from the upper member of the Lower Cretaceous Muling Formation (K1ml2) in the Laoheishan Basin, and investigated for their bulk geochemical, maceral, palynological, and terpenoid biomarker characteristics, in order to reconstruct the paleovegetation and reveal its influence on the formation of oil shale and coal. The K1ml2 is subdivided into lower, middle, and upper units. The studied oil shale samples from the lower and upper units display a high ash yield (Ad), low total organic carbon (TOC) and sulfur (S) contents, and limited hydrocarbon generation potential. The studied coal samples from the middle unit are characterized by low Ad, and high TOC and low S values, and show significant hydrocarbon generation potential. The paleovegetation during the formation of the lower unit was dominated by mire vegetation, such as shrubs (e.g., Lygodiaceae, Schizaeaceae), tree ferns (e.g., Dicksoniaceae/Cyatheaceae), and coniferous trees (e.g., Podocarpaceae). In the middle unit interval, the paleovegetation was represented by highland vegetation (Pinaceae and Araucariaceae) and peat-forming coniferous plants (e.g., Podocarpaceae, Cupressaceae/Taxodiaceae). Various vegetation, such as herbs (e.g., Osmundaceae), shrubs (e.g., Schizaeaceae), and coniferous trees (e.g., Podocarpaceae) was prosperous during the upper unit interval. Coniferous trees could provide abundant hydrogen-rich materials (e.g., resins) to the mire/lake, which may elevate the hydrogen content in peat/lake sediments, and finally result in higher hydrocarbon generation potential in the coal than in the oil shale. Therefore, the influence of paleovegetation on the formation of oil shale and coal should be fully considered when studying oil shale- and coal-bearing successions. The results also provide guidance for further exploration studies on oil shale and coal in northeast China.
Effect of Magnetic Treatment of Water or Seeds on Germination and Productivity of Tomato Plants under Salinity Stress
Authors: Samarah Nezar Husein , Bany Hani Mu’awia Muhsen Ibrahim , Makhadmeh Ibrahim Mahmoud
Published: August 2021

Salinity is an abiotic stress that reduces the seed germination and productivity of tomatoes. Magnetic treatment has been shown to have a positive effect on the seed germination, seedling growth, and productivity of various crop species. Therefore, three experiments were conducted to evaluate whether treating saline water or seeds with a magnetic field can improve the seed germination and productivity of tomatoes (Solanum lycopersicum) under salinity stress. To evaluate seed germination and seedling growth in response to a magnetic field, two laboratory experiments were carried out by passing four saline water solutions of NaCl (0, 5, 10, and 15 dS/m) through a magnetic field (3.5–136 mT) or exposing tomato seeds to the same magnetic field for 20 min before sowing. In a greenhouse experiment, plants were irrigated with different magnetically-treated and untreated saline water solutions to evaluate plant growth. Magnetic treatment of water or seeds improved seed germination percentage, speed of germination (lower mean time to germination), and seedling length and dry weight in the two laboratory experiments, especially under salinity stress of 5 and 10 dS/m. As the salinity level increased, germination performance and plant growth were significantly decreased. Irrigating tomato plants with magnetically-treated water improved plant height, stem diameter, and fruit yield per plant compared to untreated water, especially under salinity of 0 and 5 dS/m. In conclusion, magnetic treatment of saline water or seeds improved germination performance, plant growth, and fruit yield of tomatoes under saline conditions.
Assessing the Knowledge and Attitude toward COVID-19 Vaccination in Saudi Arabia
Authors: Zahid Heba M. , Alsayb May A.
Published: August 2021

COVID-19 was declared a pandemic by the WHO in March 2020. The most promising strategy to control the pandemic was to develop a vaccine. However, vaccination hesitancy is a major threat to world public health. Understanding the reasons behind this hesitancy might help in developing encouragement strategies. This cross-sectional study aimed to assess the knowledge and attitude toward the COVID-19 vaccine in Saudi Arabia. A total of 1599 responses were received; the overall vaccine acceptancy was 79.2%. Age, sex, and nationality of participants significantly predicted the vaccination status. A significantly higher proportion of participants, who reported being vaccinated, or intended to receive the vaccine, stated that the COVID-19 infection is dangerous, or varies from person to person; the vaccine is safe, and think there is a definite need for the vaccine (p < 0.001). The major encouragement factors to receive the vaccine were either confidence in the government decisions (54.8%), or the feeling of responsibility to stop the pandemic (48.7%), whereas the main discouraging factors were concerns about the insufficient clinical trials (11.4%), or the undiscovered side effects (11%). The results of this study indicate good acceptance toward the COVID-19 vaccine among residents of Saudi Arabia.
Resilience in Sports: Sport Type, Gender, Age and Sport Level Differences
Authors: Blanco-García Cecilia , Acebes-Sánchez Jorge , Rodriguez-Romo Gabriel , Mon-López Daniel
Published: August 2021

There seems to be a broad consensus that there is a positive correlation between resilience and sport performance. However, different studies show divergent results on the role played by certain variables in this relationship. This study aimed to analyze the possible relationships between resilience levels and the practiced sport according to gender, age, and competitive level of the athletes in 1047 competitive athletes from five different sports (handball, basketball, volleyball, athletics, and judo). Resilience was assessed with the Spanish version of the Brief Resilience Scale (BRS). Results of independent samples t-tests or analysis of variance (ANOVA) showed no significant differences on the level of resilience according to the practiced sport or the competitive level. However, the analyses of covariance (ANCOVA) showed that they were related to the gender and age of the athletes, being higher in males than in females, and there was a positive correlation with age. These results seem to suggest the convenience of using differentiated strategies, according to gender and age, when working on all those protective factors that could allow the athlete to perform better when facing adversity in the competitive environment.
The Onset of Depression in Middle-Aged Presumed Healthy Slovenian Family Practice Attendees and Its Associations with Genetic Risk Assessment, Quality of Life and Health Status: A Contribution for Family Medicine Practitioners’ Early Detection
Authors: Jerala Nina , Selič-Zupančič Polona
Published: August 2021

Despite depression being a major driver of morbidity and mortality, the majority of primary care patients remain undiagnosed, so this study aimed to assess the prevalence of depression and the association with demographic and clinical variables, genetic risk, and quality of life. The participants were presumably healthy model family medicine practice (MFMP) attendees between 30 and 65 years of age and recruited during a preventive check-up in 2019. Each of the 40 pre-selected MFMP pragmatically invited 30 attendees to voluntarily participate. They completed a questionnaire of demographic, clinical, and social determinants, as well as a three-generational family history. The results were analyzed using multivariable modelling to calculate the associations with signs of depression. A modified Scheuner method was used to calculate the level genetic risk level using family history. Of 968 participants, aged 42.8 ± 8.6 years, 627 (64.8%) were women. The prevalence of depression was 4.1%. Signs of depression were negatively associated with health-related quality of life score, in particular in the domains of self-care (p = 0.001) and anxiety/depression (p < 0.001). Depression was also associated with predicted high risk for comorbidities given the family history (p = 0.030). Primary care directed at improving patients’ quality of life should implement more widespread screening for mental health disorders. Family history for disease even beyond depression can be used by physicians as an important primary prevention tool.
How Does the Assessment of Work Organization during the COVID-19 Pandemic Relate to Changes in the Well-Being of Health System Workers?
Authors: Kubilienė Loreta , Griciūtė Aušra , Miglinė Vilma , Kukulskienė Milda , Stankūnienė Aurima , Žemaitienė Nida
Published: August 2021

In the case of various emergencies, especially pandemics, healthcare workers are faced with disproportionate pressures. Organizational support plays a significant role in protecting the psychological and physical health of healthcare workers. This interdisciplinary research aims to determine how changes in the physical and psychological well-being of healthcare and pharmacy workers during the first wave of the COVID-19 lockdown are related to work organization factors that support safety and stability. A quantitative research strategy was applied in the research. Data from an electronic survey assessed the changes in the physical and psychological well-being of healthcare and pharmacy workers during the lockdown period and the organizational factors supporting safety and stability. The sample of the quantitative research consisted of 967 employees of healthcare institutions and pharmacies in Lithuania. This research broadens the concept of organizational factors and provides data on their interaction with the changes of employee well-being indicators in a pandemic situation. It was found that positive changes in the evaluation of physical as well as psychological well-being during the COVID-19 lockdown could be consistently predicted by all the analyzed safety and stability supporting organizational factors that were found to be associated with subjective physical well-being and psychological well-being even when adjusting for the effect of socio-demographic factors (gender, age, work field, and specialty). The identification and proper management of organizational factors was significant for the psychological and physical well-being of healthcare workers during the lockdown period. It was found that all estimates of safety and stability supporting organizational factors during the first wave of the COVID-19 pandemic lockdown were positively related and could act as protective factors to the subjective physical and psychological well-being of healthcare and pharmacy workers.
Does Environmental Policy Affect Green Total Factor Productivity? Quasi-Natural Experiment Based on China’s Air Pollution Control and Prevention Action Plan
Authors: Li Tinghui , Ma Jiehua , Mo Bin
Published: August 2021

It is the scientific way to promote the transformation and optimization of an industrial structure to promote the improvement of its green total factor productivity (GTFP) by formulating environmental regulation policies. Based on the GTFP panel data of 30 provinces in China from 2004 to 2017, this paper takes the “Air Pollution Control and Prevention Action Plan” (APCP Action Plan) as the proxy dummy variable of environmental regulation, and uses the difference-in-differences (DID) model to explore the impact of the implementation of the APCP Action Plan on GTFP. In addition, by constructing the industrial structure optimization index, this paper analyzes how the APCP Action Plan policy affects GTFP through the transformation and optimization of industrial structure. The following basic conclusions are obtained: First, environmental regulation policies like the APCP Action Plan can improve GTFP. Second, the APCP Action Plan has regional heterogeneity in promoting GTFP in different regions. The policy only significantly affects the GTFP in the Pearl River Delta region in southern China. Third, the “quantity” and “quality” of the optimization of industrial structure will weaken the promoting effect of the APCP Action Plan on GTFP. In contrast, the rationalization of industrial structure will aggravate this promoting effect.
The Value of Active Arts Engagement on Health and Well-Being of Older Adults: A Nation-Wide Participatory Study
Authors: Groot Barbara , de Kock Lieke , Liu Yosheng , Dedding Christine , Schrijver Janine , Teunissen Truus , van Hartingsveldt Margo , Menderink Jan , Lengams Yvonne , Lindenberg Jolanda , Abma Tineke
Published: August 2021

An emerging body of research indicates that active arts engagement can enhance older adults’ health and experienced well-being, but scientific evidence is still fragmented. There is a research gap in understanding arts engagement grounded in a multidimensional conceptualization of the value of health and well-being from older participants’ perspectives. This Dutch nation-wide study aimed to explore the broader value of arts engagement on older people’s perceived health and well-being in 18 participatory arts-based projects (dance, music, singing, theater, visual arts, video, and spoken word) for community-dwelling older adults and those living in long term care facilities. In this study, we followed a participatory design with narrative- and arts-based inquiry. We gathered micro-narratives from older people and their (in)formal caregivers (n = 470). The findings demonstrate that arts engagement, according to participants, resulted in (1) positive feelings, (2) personal and artistic growth, and (3) increased meaningful social interactions. This study concludes that art-based practices promote older people’s experienced well-being and increase the quality of life of older people. This study emphasizes the intrinsic value of arts engagement and has implications for research and evaluation of arts engagement.
Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies
Authors: Mamun Abdullah Al , Pidaný Filip , Hulcová Daniela , Maříková Jana , Kučera Tomáš , Schmidt Monika , Catapano Maria Carmen , Hrabinová Martina , Jun Daniel , Múčková Lubica , Kuneš Jiří , Janoušek Jiří , Andrýs Rudolf , Nováková Lucie , Peřinová Rozálie , Maafi Negar , Soukup Ondřej , Korábečný Jan , Cahlíková Lucie
Published: August 2021

Alzheimer’s disease (AD) is a multifactorial neurodegenerative condition of the central nervous system (CNS) that is currently treated by cholinesterase inhibitors and the N-methyl-d-aspartate receptor antagonist, memantine. Emerging evidence strongly supports the relevance of targeting butyrylcholinesterase (BuChE) in the more advanced stages of AD. Within this study, we have generated a pilot series of compounds (1–20) structurally inspired from belladine-type Amaryllidaceae alkaloids, namely carltonine A and B, and evaluated their acetylcholinesterase (AChE) and BuChE inhibition properties. Some of the compounds exhibited intriguing inhibition activity for human BuChE (hBuChE), with a preference for BuChE over AChE. Seven compounds were found to possess a hBuChE inhibition profile, with IC50 values below 1 µM. The most potent one, compound 6, showed nanomolar range activity with an IC50 value of 72 nM and an excellent selectivity pattern over AChE, reaching a selectivity index of almost 1400. Compound 6 was further studied by enzyme kinetics, along with in-silico techniques, to reveal the mode of inhibition. The prediction of CNS availability estimates that all the compounds in this survey can pass through the blood-brain barrier (BBB), as disclosed by the BBB score.
Mitochondria Can Cross Cell Boundaries: An Overview of the Biological Relevance, Pathophysiological Implications and Therapeutic Perspectives of Intercellular Mitochondrial Transfer
Authors: Valenti Daniela , Vacca Rosa Anna , Moro Loredana , Atlante Anna
Published: August 2021

Mitochondria are complex intracellular organelles traditionally identified as the powerhouses of eukaryotic cells due to their central role in bioenergetic metabolism. In recent decades, the growing interest in mitochondria research has revealed that these multifunctional organelles are more than just the cell powerhouses, playing many other key roles as signaling platforms that regulate cell metabolism, proliferation, death and immunological response. As key regulators, mitochondria, when dysfunctional, are involved in the pathogenesis of a wide range of metabolic, neurodegenerative, immune and neoplastic disorders. Far more recently, mitochondria attracted renewed attention from the scientific community for their ability of intercellular translocation that can involve whole mitochondria, mitochondrial genome or other mitochondrial components. The intercellular transport of mitochondria, defined as horizontal mitochondrial transfer, can occur in mammalian cells both in vitro and in vivo, and in physiological and pathological conditions. Mitochondrial transfer can provide an exogenous mitochondrial source, replenishing dysfunctional mitochondria, thereby improving mitochondrial faults or, as in in the case of tumor cells, changing their functional skills and response to chemotherapy. In this review, we will provide an overview of the state of the art of the up-to-date knowledge on intercellular trafficking of mitochondria by discussing its biological relevance, mode and mechanisms underlying the process and its involvement in different pathophysiological contexts, highlighting its therapeutic potential for diseases with mitochondrial dysfunction primarily involved in their pathogenesis.