bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Kepemilikan Manajerial Terhadap Corporate Social Responsibility
Authors: Purwanto Eko
Published: July 2023

Penelitian ini bertujuan untuk memberikan gambaran terhadap faktor yang memberikan pengaruh terhadap pengungkapan CSR pada perusahaan farmasi yang teraftar di Bursa Efek Indonesia pada periode 2016 - 2020. Variabel dependen pada penelitian ini adalah pengungkapan CSR dan variabel independen pada penelitian ini adalah kepemilikan manajerial pada seluruh perusahaan farmasi yang terdaftar di Bursa Efek Indonesia periode 2016 – 2020. Populasi dari penelitian adalah laporan keuangan yang diperoleh dari website resmi BEI dengan jumlah sampel 10 perusahaan yang diambil sesuai kriteria. Teknik pengujian data dilakukan dengan uji asumsi klasik, uji koefisien regresi linier berganda, uji determinasi, uji korelasi dan uji hipotesis. Hasil penelitian ini menunjukkan bahwa kepemilikan manajerial berpengaruh terhadap pengungkapan CSR.
HUBUNGAN WORK-FAMILY CONFLICT DENGAN KEPUASAN PERNIKAHAN PADA ISTRI YANG MENJADI TULANG PUNGGUNG KELUARGA DI DESA JELEGONG RANCAEKEK
Authors: Anggarwati Fitria Rizqi , Kuswartanti Dyah Rachman , Annisa Nida Muthi
Published: July 2023

A working wife will have an impact on the emergence of work-family conflict on the wife and this will be related to the wife's satisfaction with her marriage. This study aims to determine the relationship between work-family conflict and marital satisfaction for the wife who is breadwinner of the family at Jelegong Rancaekek village. Respondents in this study amounted to 75 wifes with the criteria; living in Jelegong Rancaekek Village, working and being the breadwinner and living in the same house with their husband. The method of research used quantitative with correlational research. The population and sample technique used is population research, the data collection method used a questionnaire in the form of a questionnaire and the research using two measuring, namely the work-family conflict measurement (WFC) and the marital satisfaction measurement (ENRICH). The data analysis technique used in this study uses the product-moment technique with the help of SPSS version 22. Based on the results of data analysis, the significance level is 0.000 with a correlation value of 0.722. This shows that work-family conflict has a positive relationship with marital satisfaction for the wife who is the breadwinner of the family in Jelegong Rancaekek Village, so it can be interpreted that the higher the work-family conflict, the marital satisfaction will increase, and vice versa.
Penerapan Kebijakan Reorder Point pada Data Hasil Prediksi Permintaan Komponen Darah menggunakan Metode Peramalan Dekomposisi Aditif dan Pengendalian Persediaan Probabilistik
Authors: Febryan Arrizal Fitrah , Nahar Julita , Djauhari Eddy
Published: July 2023

Memasuki awal Maret 2020, pandemi COVID-19 menjadi sebuah tantangan di sektor kesehatan. Permintaan darah di UTD PMI Kabupaten Serang mengalami kecenderungan meningkat setiap minggunya sepanjang tahun 2020 sehingga instansi sering mengalami kekurangan pada komponen darah. Kelancaran dalam pelaksanaan pemenuhan darah akan sangat bergantung pada perencanaan persediaan yang optimal. Selain itu, komponen darah tidak memiliki daya tahan atau umur yang lama. Tujuan penelitian ini adalah melakukan peramalan jumlah permintaan darah berdasarkan komponen serta menentukan jumlah reorder point yang dapat diterapkan terhadap setiap komponen darah. Metode peramalan yang digunakan adalah Metode Dekomposisi Aditif dan Pengendalian Persediaan Probabilistik. Hasil peramalan permintaan komponen darah pada 01 Maret s.d 04 April 2021 dengan Metode Dekomposisi Aditif memperoleh komponen darah PRC (Packed Red Cell) yang kecenderungan menurun dan menghasilkan keakuratan peramalan sangat baik. Komponen darah WB (Whole Blood) mengalami kecenderungan meningkat dan menghasilkan keakuratan peramalan cukup. Komponen darah TC (Thrombocyte Concentrates) mengalami kecenderungan menurun dan menghasilkan keakuratan peramalan cukup. Instansi dapat melakukan pemenuhan persediaan darah pada 01 Maret s.d 04 April 2021 dengan perancangan kebijakan reorder point terhadap ketiga komponen darah dengan service level yang diterapkan pada rentang 90%-99%. Semakin tinggi service level yang diterapkan, maka semakin jarang terjadinya stock out pada komponen darah.
Pengaruh Pertumbuhan Perusahaan Terhadap Penerimaan Opini Audit Going Concern
Authors: Putri Anike
Published: July 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pertumbuhan perusahaan terhadap penerimaan opini audit going concern. Penelitian ini dilakukan pada perusahaan sektor pertambangan yang terdaftar di Bursa Efek Indonesia tahun 2017-2021. Metode penelitian yang digunakan pada penelitian ini adalah metode deskriptif kuantitatif. Data yang digunakan adalah data sekunder. Data sekunder bersumber dari laporan tahunan perusahaan. Model analisis data yang digunakan adalah analisis regresi logistik. Berdasarkan hasil uji statistik, disimpulkan bahwa pertumbuhan perusahaan secara parsial tidak berpengaruh terhadap penerimaan opini audit going concern pada perusahaan sektor pertambangan yang terdaftar di Bursa Efek Indonesia tahun 2017-2021.
Analisis Sentimen dengan Metode Klasifikasi Naïve Bayes Dan Seleksi Fitur Information Gain
Authors: Kustanto Natalia Syafitri , Gusriani Nurul , Firdaniza Firdaniza
Published: July 2023

Analisis sentimen merupakan pemrosesan bahasa alami yang bertujuan untuk menemukan opini, mengidentifikasi sentimen apa yang diungkapkan, dan mengklasifikasikannya berdasarkan nilai yang terkandung. Teknologi pembelajaran mesin, seperti Klasifikasi Naïve Bayes banyak digunakan dalam klasifikasi sentimen karena memiliki tingkat akurasi dan kecepatan yang tinggi. Pembelajaran mesin dapat dipadukan dengan metode seleksi fitur untuk meningkatkan efisiensi model. Salah satu metode seleksi fitur adalah metode Information Gain yang dapat digunakan untuk menentukan atribut paling efektif. Penelitian ini bertujuan untuk menganalisis sentimen masyarakat terhadap aplikasi PeduliLindungi dan menghitung evaluasi performa model berdasarkan nilai metrik F1-Score. Pada penelitian ini analisis sentimen dilakukan menggunakan metode Klasifikasi Naïve Bayes dengan penggabungan metode seleksi fitur Information Gain untuk meningkatkan performa model dan mempercepat komputasi. Hasil analisis sentimen menggunakan metode klasifikasi Naïve Bayes dan seleksi fitur Information Gain menunjukkan bahwa pengguna cenderung memberikan ulasan positif terhadap aplikasi PeduliLindungi. Performa model untuk analisis sentimen pengguna terhadap aplikasi PeduliLindungi ditentukan berdasarkan rata-rata F1-Score dengan 10-fold cross validation diperoleh sebesar 95.1%; artinya model yang diperoleh mempunyai presisi dan recall yang baik.
Script R Terintegrasi Berbasis Web Application untuk Model Markov Average-Based Weighted Fuzzy Time Series
Authors: Risdawati Risdawati , Firdaniza Firdaniza , Subartini Betty
Published: July 2023

Salah satu model yang baik untuk memprediksi data adalah model Fuzzy Time Series. Model tersebut sudah banyak digunakan oleh para peneliti, namun untuk proses pengolahan data masih dengan semi manual. Seiring dengan perkembangan ilmu pengetahuan, pengolahan data dapat dilakukan dengan bantuan software lainnya, salah satunya adalah software R. R memiliki banyak kelebihan diantaranya open source, gratis, dan memliki fitur yang komplit. Pada penelitian ini dibangun script R terintegrasi untuk model Markov Average-Based Weighted Fuzzy Time Series (ABW-FTS) berbasis web application dengan RShiny. Tahapan yang dilakukan dalam membuat web application shiny yaitu dengan membuat script User Interface (UI), script server, dan mempublikasikan aplikasi pada shinyapps.io. Script R kemudian diterapkan untuk memprediksi jumlah penjualan mobil toyota di Indonesia. Hasil prediksi dengan model Markov Average-Based Weighted Fuzzy Time Series (ABW-FTS) tergolong akurat dengan rata-rata nilai Mean Absolute Percentage Error (MAPE) sekitar 12%.
Pengaruh Whistleblowing System dan Tata Kelola Terhadap Kemampuan Mendeteksi Kecurangan Laporan Keuangan Perusahaan Manufaktur
Authors: Faiqoh Elok , Ardiansyah Aceu
Published: July 2023

Penelitian ini bertujuan untuk mengetahui ada pengaruh atau tidak wistleblowing system dan tata kelola perusahaan terhadap kecurangan laporan keuangan. Metode penelitian ini menggunakan metode regresi linier berganda. Pada hasil uji analisis diketahui bahwa kedua variabel independen tersebut yaitu whistleblowing system dan tata kelola perusahaan memiliki pengaruh signfikan terhadap kecurangan laporan keuangan. Pengaruh signifikan yang dimaksud adalah semakin tinggi penerapan whistleblowing system semakin rendah tingkat kecurangan laporan keuangan, sehingga whistleblowing system dapat dijadikan sebagai tindak preventif atas kecurangan laporan keuangan perusahaan manufaktur. Kemudian, tata kelola perusahaan memiliki pengaruh signifikan artinya semakin bagus tata kelola perusahaan dalam hal ini kepimilikan manajerial, maka semakin rendah kecurangan laporan keuangan pada perusahaan manufaktur. Perusahaan yang digunakan pada sampel ini adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia Tahun 2019-2022.
Penjadwalan Housekeepers Hotel Pada Era Pandemi COVID-19 dengan Pendekatan Goal Programming
Authors: Sutisna Yoga , Hidayanti Monika , Supian Sudradjat
Published: July 2023

Housekeepers mempunyai peranan penting dalam oprasional hotel karena kebersihan dan kenyamanan merupakan daya tarik hotel, terutama pada era pandemi COVID-19. Namun, pada saat pandemi banyak industri perhotelan yang mengalami penurunan nilai Tingkat Penghunian Kamar (TPK) sehingga menyebabkan beberapa hotel terpaksa tutup termasuk di wilayah Jawa Barat. Hal tersebut mengakibatkan beberapa pegawai dirumahkan termasuk Housekeepers, maka dari itu penjadwalan harus diatur kembali agar tidak ada pengurangan pegawai. Penelitian ini dimaksudkan untuk menentukan penjadwalan Housekeepers dengan pendekatan Goal Programming di era pandemi COVID-19 studi kasus di Hotel R Kota Bandung. Perbedaan pada saat pandemi COVID-19 ini terdapat pada jumlah Housekeepers yang berbeda dikarenakan ada pengurangan pada saat pandemi, sehingga dapat menambah beban kerja bagi Housekeepers lain. Hal tersebut dibuktikan dari hasil penjadwalan menggunakan software LINGO 11.0 yang disesuaikan dengan fungsi tujuan untuk meminimumkan penyimpangan pada setiap kendala. Dari hasil yang didapatkan diperoleh perbedaan dari jumlah jam kerja serta libur bagi Housekeepers sebelum dan sesudah pandemi COVID-19 akan tetapi memiliki penyimpangan sama dengan nol.
HUBUNGAN ANTARA SELF REGULATED LEARNING DENGAN PROKRASTINASI AKADEMIK DIMASA PEMBELAJARAN DARING PADA SISWA KELAS XII SMA NEGERI 1 CIAWIGEBANG
Authors: Anam Imatul , Hastuti Evi Srinur , Sinaga Anggian Heksa Efraim
Published: July 2023

Academic procrastination is a tendency to procrastinate activities related to academics. Students in the learning process need self-regulated learning abilities that help students manage thoughts, behaviors, and emotions so that they can successfully direct the learning process towards the learning goals to be achieved. The purpose of the study was to determine the relationship between self-regulated learning and academic procrastination during online learning in class XII students of SMAN 1 Ciawigebang. The research method used is the correlation method, which is to see the relationship between self-regulated learning variables and academic procrastination during online learning in class XII students of SMAN 1 Ciawigebang. The data collection technique used a questionnaire made in the form of google from. The measuring instrument for self-regulated learning variables is based on Zimmerman's theory (2011) and for academic procrastination variables based on  McCloskey's  theory  (2011). The  results  showed  that  there  was a  negative  and  significant relationship between self-regulated learning and academic procrastination during online learning in class XII students of SMAN 1 Ciawigebang, with a value of rs = -0.800. The lower the self- regulated learning, the higher the academic procrastination in class XII students of SMAN 1 Ciawigebang. On the other hand, the higher the self-regulated learning, the lower the academic procrastination in class XII students of SMAN 1 Ciawigebang.
Analisis Kinerja Keuangan PT Telekomunikasi Indonesia, Tbk Menggunakan Analisis Rasio Keuangan untuk Menilai Kinerja Keuangan Perusahaan Periode 2012–2021
Authors: Simarmata Harianto
Published: July 2023

PT Telekomunikasi Indonesia, Tbk adalah salah satu penyedia layanan telekomunikasi terkemuka di Indonesia. Penelitian ini di PT Telekomunikasi Indonesia Tbk bertujuan untuk mengevaluasi kinerja keuangan perusahaan dengan menggunakan analisis rasio keuangan, yaitu rasio likuiditas (Current Ratio), rasio solvabilitas (Debt to Assets Ratio), dan rasio profitabilitas (Net Profit Margin dan Return on Equity), berdasarkan laporan keuangan perusahaan tahun 2012-2021. Tingkat likuiditas perusahaan, yang diukur dengan Current Ratio selama periode 2012-2021, rata-rata sebesar 101,96%, menunjukkan kondisi yang tidak menguntungkan karena berada di bawah standar industri sebesar 200%. Tingkat solvabilitas PT. Telekomunikasi Indonesia Tbk., yang diukur dengan Debt to Assets Ratio selama 2012-2021, rata-rata sebesar 43,60% yang menunjukkan kondisi yang baik karena berada di atas standar industri sebesar 35%. PT. Telekomunikasi Indonesia Tbk., yang diukur dengan Net Profit Margin sebesar 23,185%, menunjukkan hasil yang cukup baik karena berada di atas rata-rata industri sebesar 20% dan diukur melalui Return on Equity selama 2012-2021, rata-rata sebesar 25,461% yang menunjukkan kondisi yang tidak menguntungkan karena berada di bawah standar industri sebesar 40%.
Keputusan Invesasi dengan Menggunakan Metode Capital Asset Pricing Model (CAPM)
Authors: Ningrum Retno Widya
Published: July 2023

Penelitian ini bertujuan untuk menentukan kondisi saham-saham yang mendorong JCI yang terlalu murah atau terlalu mahal, serta keputusan investasi yang berkaitan dengan hasil perhitungan menggunakan metode CAPM. Studi ini menggunakan metode penelitian deskriptif dengan pendekatan kuantitatif. Pemilihan sampel menggunakan metode purposive sampling dengan dua kriteria, yaitu (1) saham-saham dengan kapitalisasi pasar minimum sebesar IDR 50 triliun, dan (2) telah terdaftar di Bursa Efek Indonesia (IDX) sejak Januari 2018, dan diperoleh 9 saham sampel. Dari hasil penelitian ini diketahui bahwa terdapat 8 saham yang terlalu murah dengan keputusan investasi untuk membeli/menahan (hold), dan 1 saham yang terlalu mahal dengan keputusan investasi untuk menjual (sell).
Growth Strategy untuk Meningkatkan Daya Saing Koperasi Peternakan Bandung Selatan (KPBS) Pangalengan
Authors: Dewi Wulan Sari , Hafizhah Salsabila , Aprianti Vika
Published: July 2023

Penelitian ini bertujuan untuk memberikan usulan strategi bisnis untuk meningkatkan daya saing pada Koperasi Peternakan Bandung Selatan (KPBS) Pangalengan, dengan serangkaian perangkat yang digunakan untuk menganalisis lingkungan perusahaan, formulasi strategi, dan pemilihan strategi terbaik. Metode penelitian menggunakan pendekatan kuantitatif untuk menganalisis kondisi, mengetahui fenomena lingkungan internal dan eksternal, perumusan alternatif strategi menggunakan Analisa SWOT dengan pemetaan BCG Matrix (Modifikasi), GE Matrix (Orisinal), dan TOWS matriks. Hasil penelitian mengungkapkan nilai skor IFAS sebesar 4,9 dan EFAS 5,52 (keduanya diatas 2,5 (titik tengah)). Hal ini menyatakan PT. KPBS Pangalengan mampu mengatasi kekuatan, kelemahan, peluang dan ancaman. Selanjutnya, Alternatif Strategi diperoleh bahwa strategi prioritas yang diusulkan bagi PT. Susu KPBS Pangalengan yaitu Growth Strategy, strategi yang fokus pada pertumbuhan yang cepat, perusahaan dapat memperkuat posisinya di pasar dan meningkatkan pangsa pasar dengan memperluas wilayah geografis atau menambah lini produk.
Sistem Pakar Diagnosa Kerusakan Motor Matic Injection Menggunakan Metode Forward Chaining Berbasis Web
Authors: Selan Roni Dedi , Nababan Darsono , Kelen Yoseph P.K , Ullu Hevi Herlina
Published: July 2023

Pada umumnya masyarakat menggunakan sepeda motor sebagai alat transportasi utama dikarenakan sepeda motor dapat menghemat waktu dan tenaga serta biaya menuju tempat tujuan, yang salah satunya adalah motor matic injection. Namun demikian, motor matic injection juga memiliki kendala yang dapat menyebabkan kerusakan sehingga mengganggu aktivitas yang dilakukan. Sistem pakar berbasis web dapat digunakan untuk memecakan masalah dalam hal mendiagnosa kerusakan pada motor matic injection. Metode yang digunakan dalam mendiagnosa kerusakan motor matic injection adalah metode forward chaining. Proses metode forward chaining dimulai dengan menampilkan kumpulan data atau fakta-fakta yang diperoleh, kemudian diproses untuk mencapai suatu kesimpulan akhir yang diinginkan. Dari hasil penelitian dapat disimpulkan bahwa sistem pakar yang dibangun diharapkan mampu membantu masyarakat dalam mendiagnosa kerusakan pada motor matic injection sesuai dengan hasil perhitungan metode forward chaining yang didapat.
Multimedia Pembelajaran TIK Bagi Siswa Sekolah Dasar Menggunakan Aplikasi MINLearn
Authors: Apryanti Nurliah , Kelen Yoseph Pius Kurniawan , Tey Seran Krisantus Jumanto
Published: July 2023

Pengenalan akan pembelajaran Teknologi Informasi dan Komunikasi (TIK) menjadi satu hal yang penting dalam upaya untuk mengembangkan sistem pembelajaran yang berkembang dan tersistem. Untuk perlu adanya inovasi yang ikut mendorong perubahan tersebut. Madrasah Ibtidaiyah Negeri (MIN) Kefamenanu memiliki sistem pendidikan yang terintegritas dengan sangat baik, namun untuk kurikulum yang membahas akan TIK belum memadai. Melihat masalah di atas maka dalam penelitian ini dikembangkan sebuah aplikasi multimedia pembelajaran yang dapat membantu siswa-siswi di MIN Kefamenanu dalam mengenal TIK dan Perangkat Komputer. Aplikasi yang dibangun bernama MINLearn yaitu sebuah sebuah aplikasi berbasis android yang didalamnya berisi tentang materi pembelajaran TIK dan Komputer. Selain itu aplikasi ini memiliki menu quiz untuk mengukur kemampuan siswa-siswi tentang pengetahuan materi yang telah dipelajari. Dalam mengembangkan MINLearn digunakan Metode Waterfall. Pengembangan sistem dengan metode ini bekerja secara tahap demi tahap atau secara sistematis dan berurutan. Dengan menggunakan aplikasi ini pada MIN Kefamenanu siswa-siswi di sekolah ini dapat terbantu dalam pengenalan materi TIK dan Komputer. Hal ini ditunjukkan dengan tingkat kepuasan siswa-siswi yang sudah menggunakan aplikasi ini sebesar 90% mengatakan SANGAT BAIK.
Sintesis Khalkon dan Uji Aktivitas Tabir Surya Secara In Vitro
Authors: Napu Dewi Darmiyani
Published: July 2023

Synthesis of 2’,4’-dihydroxy-3,4-dimethoxychalcone and in vitro test of its sunscreen activity have been carried out. Chalcone was synthesized from 3,4-dimethoxybenzaldehyde and 2,4-dihydroxyacetophenone through Claisen-Schmidt condensation. The synthesis was performed by using KOH 40% under stirring at room temperature for 48 h. The synthesized compounds was characterized using FTIR, GC-MS and 1H NMR spectrometers. Further, the chalcone were screened for its in vitro sunscreen activity by using UV-Vis spectrophotometer. The result showed that the chalcone has been succesfully synthesized in 36.94% Yield. The activity of invitro test showed the chalcone has SPF values with maximal protection category at the consentration 15 µ/mL produce SPF 9.749
Karakterisasi Proses Pembuatan Simplisia Daun Sirih Hijau (Piper Betle) Sebagai Sediaan Obat Penyembuhan Luka
Authors: Kiko Paskalis Trianus , Taurina Wintari , Andrie Mohamad
Published: July 2023

Green betel leaf (Piper betle) is used in the manufacture of wound healing preparations, has a function as an antiseptic and eugenol that can kill bacteria. This study aims to characterize the process of making simplicia and simplicia green betel leaf (Piper betle L.) obtained at Jalan Parit Demang, Gg. Kulang Leather, Parit Tokaya No. 6, South Pontianak District, Pontinanak City, West Kalimantan 78121 which is used as raw material for wound healing drug preparations. Green betel leaf simplicia was characterized biologically including habitat, morphology, physically including organoleptic, microscopic, water content, ash content, and acid insoluble ash content, as well as chemically namely phytochemical screening. This characterization is also carried out in the process of making simplicia picking, wet sorting, packing, washing, dry sorting, making simplicia, packaging, and storage. The yield of simplicia was 23.27%. The results of the characterization of green betel leaf are at an altitude of 200-1000 m above sea stage which has a rainfall of 2250-4750 mm in keeping with year. Heart-fashioned leaves, sleek leaf surface, pointed with a leaf period of 6-17.5 cm and a width of 3.5-10 cm.betle leaves have a distinctive aroma, taste slightly spicy, and greenish brown in color. The water content, ash content, acid insoluble ash content and total phenol in green betel leaf simplicia were 12.8%, 7.04%, 3.13%, phenol content 760 nm, absorbance 0.0520 and obtained levels of 23.3379 ppm. Positive for alkaloids, flavonoids, saponins, triterpenoids, tannins.
Penetapan Kadar Paracetamol dalam Jamu di Kota Pontianak Menggunakan Instrumen Spektrofotometri UV-Vis
Authors: Nugraha Fajar , Kurniawan Hadi , Yastiara Iga
Published: July 2023

Jamu is a traditional medicine used for generations in Indonesia. There are many regulations for jamu in Indonesia, one of which is the Regulation of the Minister of Health number 7 of 2012. The Minister of Health regulates the prohibition of distribution of jamu containing medicinal chemicals (BKO) that can endanger health. However, there are still many herbs containing BKO circulating in Indonesia, one of which is paracetamol. This study aims to verify the analytical method and measure the levels of paracetamol of jamu in Pontianak City, West Kalimantan. The verification of the analytical methods in this study is the measurement of linearity, accuracy, precision, Limit of Detection (LOD), and Limit of Quantification (LOQ). 3 (three) samples with different brands and indications were obtained through purchases from online shops. UV-Vis spectrophotometry used as a quantitative analytical instrument. The results of the linearity test obtained an r value of 0.999 and an r2 value of 0.999 which met the requirements of ICH, SNI, AOAC, and Eurachem. The results of the accuracy test have a %recovery range of 97.1986-102.2856% which meets the AOAC requirements. The results of the precision test have a %RSD range of 1.8197-7.7966% which meets the AOAC and Horwitz requirements. The results of the LOD calculation are 0.3273 ppm and the LOQ value is 0.9918 ppm. The results of the analysis using UV-Vis spectrophotometry were samples A, B, and C containing paracetamol with levels of 5.1667% each; 18.9809%; and 22,9167%.
Hubungan Pengetahuan dan Sikap terhadap Pola Penggunaan Obat Tradisional untuk Swamedikasi di Masyarakat Kota Denpasar
Authors: Maharianingsih Ni Made
Published: July 2023

The behavior of self-medication in Indonesian society is quite large and one of the classes of drugs that can be used for self-medication is traditional medicine. The use of traditional medicine is influenced by the knowledge and attitudes of the community. This research aims to determine the relationship between knowledge and attitudes towards patterns of use of traditional medicine for self-medication in the community in Denpasar City. The research method used was an observational analytic cross-sectional study. The location used in this study is the city of Denpasar, with the time of the study taking place in July-September 2020. The research subjects are people who live in Denpasar City aged 20-64 years who buy and use traditional medicines with a total of 400 people. Data were collected by distributing questionnaires to research subjects to measure knowledge, attitudes, and patterns of use of traditional medicines. The results obtained were the pattern of self-medicated traditional medicine in most of the community with the frequency of using drugs more than 4 times a month (23.25%), the most common complaints were headaches (32.5%), the type of traditional medicine was the branded herbal medicine class %), the effect that was felt from the use of traditional medicine was getting better (98.5%) with no side effects (87.25%). Most of the information sources of traditional medicine were from the family (50.25%). Knowledge and attitudes of the people of Denpasar city are mostly classified as high with a percentage of 67.25% for knowledge and 65.50% for attitudes. It can be concluded that there is a significant or moderate relationship between knowledge and the respective patterns of use of traditional medicines, except for the relationship between attitudes and low or weak prices of traditional medicines.
Comparison Study of Caffeine Levels of Coffee Bean (Coffea Sp.) and Brands of Coffee Powder Circulate in Banda Aceh City
Authors: Prayoga Andre , Zumaira Zumaira
Published: July 2023

Coffee is one of the plantation commodities that has a fairly high economic value compared to other plantation crops and plays an important role as a source of foreign exchange for the country. Caffeine belongs to the methylxanthine group of compounds. Methylxanthine is a naturally occurring compound and belongs to the xanthine derivative which is a group of alkaloid compounds. To determine the difference in caffeine content between coffee beans and coffee grounds circulating in supermarkets in Banda Aceh. This type of research is a descriptive method with a purposive sampling method used. This research was carried out by analyzing the levels of caffeine in coffee beans and packaged coffee powder circulating in supermarkets in the city of Banda Aceh by UV-Vis Spectrophotometry. The results obtained from the manufacture of standard solutions are 273,20 nm, the correlation coefficient value is r of 0.99995, and the equation y = 0.0483x + 0.01098. From the research data obtained caffeine levels, namely samples of Robusta coffee beans with 0.305%, samples of Meulawi Coffee powder with 0.402%, samples of Arabica Coffee beans with 0.815%, samples of Solong Coffee powder with 1.498%, samples of King Coffee coffee powder with 2.256%. The highest level is in King Coffee powder with 2.256% and the lowest is boiled coffee beans with 0.305%. The difference in caffeine content of each coffee sample is caused by various factors, namely the method of roasting, storage, and treatment.
Kajian in Silico Daun Sungkai (Peronema canescens) dalam Menghambat Enzim lanosterol 14-α demethylase Jamur Candida albicans
Authors: Istiqomah Nurul , Fatikasari Safitri
Published: July 2023

Candida albicans (C. albicans) is a fungus that causes candidiasis. C. albicans has the enzyme Lanosterol 14- α demethylase. Lanosterol 14-α-demethylase has bioactivity in converting lanosterol to ergosterol, a special sterol found in fungal membranes, which mediates membrane permeability and fluidity. One way to treat candidiasis is to use traditional medicinal plants. Sungkai (Peronema canescens) can be used as an anti-fungal medicine. Drug development efforts can be done using the In silico method. Objectives of this study was to determine the interaction between terpenoid, flavonoid, and phenol compounds in Sungkai leaves against Lanosterol 14-α demethylase in Candida albicans. The research design used was a pre-experimental one-shot case study. Toxtree software was used to test the toxicity of compounds. Test for compound potency using the Pass Online webserver. Docking molecular using PyRx software. Visualization of docking results using Discovery Studio 2019 Software. Physicochemical test of compounds using Lipinski Test. The results showed that the compounds that had a low risk of toxicity were butanoic, catechol, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and phytol. Compounds that have anti-fungal activity based on Pharma-expert analysis are butanoic acid, genkwanin, guaiacol, hydroquinone, isopropanol, palmitic acid, and phytol. Compounds that have hydrogen bonds and binding affinity value 10 and RMSD value 2 are butanoic acid, catechol, genkwanin, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and quinic acid compounds. These compounds are thought to inhibit the Lanosterol 14-alpha demethylase enzyme in C. albicans. Compounds that comply with Lipinski's rules are anthocyanin and genkwanin compounds. The groups of compounds found in Sungkai leaves that have antifungal activity are the terpenoids, flavonoids, and phenols.
Perbandingan Manifestasi Klinis Penderita Demam Berdarah
Authors: Ahmad Zul Fikar , Salsabila Mongilong Nadila , Kadir Laksmyn , Indah Nurdin St. Surya , Rahmawaty Moo Dewi
Published: July 2023

Dengue hemorrhagic fever has spread throughout the region, especially in tropical and warm climates. Dengue fever has become a global health problem and causes outbreaks almost every year. This study aims to compare the clinical manifestations of DHF patients in pediatrics and adults. This study used a health center-based cross-sectional approach and used secondary data on DHF sufferers from 2019-2022 at the Tutuyan Health Center, namely 72 sufferers. Clinical manifestations of fever are symptoms that generally appear in patients with DHF (100%), and headaches (72.2%), vomiting (40.3%), nausea (34.7%). Meanwhile, the few symptoms found were abdominal pain (15.3%), aches (15.3%), rash (11.1%), joint pain (9.7%), and seizures (8.3%). Abdominal pain, joint pain, aches, nausea, and vomiting are commonly found in adults, while rashes and seizures are commonly found in pediatrics. More efforts are needed to strengthen national programs and thereby reduce the morbidity, mortality, and social and economic burden generated by DHF outbreaks and epidemics
Kepatuhan Minum Obat Antidiabetika Oral Pasien Ulkus Diabetikum Rawat Jalan di Klinik X Kota Pontianak Menggunakan Metode Kuantitatif
Authors: Laoura Prita , Nurmainah Nurmainah , Susanti Ressi
Published: July 2023

Non-communicable diseases (PMT) have increased globally and nationally which have occupied the top ten causes of death with the most cases being diabetes mellitus. Diabetes Mellitus is a chronic disease that occurs due to impaired insulin action which causes blood sugar levels to increase. Uncontrolled sugar levels cause complications, one of which is diabetic ulcers. This study aims to analyze the level of adherence in taking medication in patients and the factors that influence adherence in taking medication in diabetic ulcer patients at Clinic Pontianak. The method used in this research is analytic observational method with the research design used is a cohort study. Compliance with drug use was measured using the Medication Possession Ratio (MPR) method. Data collection was carried out retrospectively based on manual and electronic data collection (medical records) and outpatient diabetic ulcer patient prescriptions at the Clinic Pontianak from January to December. Analysis of compliance relationship data using the chi square test. The results of this study showed that patients tended to be 45 years old (16.7%), female sex (87.5%), and monotherapy regimen (87.3%), this stated that there was no significant relationship between compliance with patient characteristics. Based on the results of the research, the percentage of compliance with the use of oral anti-diabetic drugs in outpatient diabetic ulcer patients at the Pontianak Clinic  in 2021 is 26.1%.
Analisis Potensi Farmakokinetik dan Toksisitas Pada Curcumin (Curcuma xanthorrhiza) Sebagai Brightening Terhadap Reseptor Protein Tirosinase Secara in Silico
Authors: Wilapangga Anjas
Published: July 2023

Tyrosinase enzyme is an enzyme that plays an important role in melanin synthesis. This enzyme will oxidize the amino acid L-tyrosine into L- 3,4 dihydroxyphenylalanine (L-DOPA) and convert L-DOPA into DOPAquinone. Tyrosinase protein from Bacillus megaterium in complex with inhibitor kojic acid is the target protein that will interact with the ligand (Drug Candidate), Temulawak (Curcuma xanthorrhiza) is one of the medicinal plants of the Zingiberaceae family which is widely grown and used as a raw material for traditional medicine in Indonesia, the main content in Temulawak is curcumin which has antioxidant properties. Antioxidants in curcumin content can be used as ingredients for whitening preparations. In silico tests are used to predict pharmacokinetic activity and toxicity by docking using the Molegro Virtual Docker computer program. The receptor used was Protein Tyrosinase PDB code 3NQ1 with ligand KOJ_B_1351. Prediction of pharmacokinetic properties (ADME) and toxicity of Curcumin and Kojic Acid was performed using the pkCSM online tool program. Data analysis was performed by comparing the binding energy of docking results between Curcumin, Kojic Acid, and ligand on the target receptor. The in silico test results showed that the binding energy of Kurkumin =-142.766 kcal/mol, Kojic Acid = -60.6899 kcal/mol, and KOJ_B_1351 ligand =-62.266 kcal/mol. The results of in silico tests using the pkCSM online tool program show that Kurkumin compounds have good pharmacokinetic properties, and cause relatively low toxicity, and can be used as candidates for whitening materials.
Efektivitas Ekstrak Spirulina platensis terhadap Jumlah Fibroblas pada Tikus yang Dilakukan Insisi pada Kulitnya
Authors: Utami Riski Dwi , Misfa Olvaria , Irenesia Bimby , Marwan Deinike Wanita
Published: July 2023

Fibroblasts play a role in the wound healing process. The active compound content of Spirulina sp. has fibroblastic activity. The use of extracts from S. platensis can play a role in the wound healing process. To analyze the effectiveness of Spirulina platensis extract on the number of fibroblasts in rats that were incised in their skin. This study used a randomized post test only control group design. Forty-eight male Wistar rats were skin incised and infected with S.aureus divided into 4 groups, namely the group given S.platensis extract at a dose of 500 mg/kgBW/day, a dose of 750 mg/kgBW/day, the negative control group was given saline solution and positive control group with diclofenac 20 mg/kgBW orally. The number of fibroblasts was counted on histopathological examination of the wound tissue on the 7th and 14th days covering 5 visual fields. Data analysis was carried out with a one way ANOVA test and continued with the LSD Post Hoc Test. The mean number of fibroblasts on the 7th day in the 500 mg/kgBW/day group, 750 mg/kgBW/day, positive control and negative control was 13.33 ± 3.615; 117.42±3.980; 9.58±2.417; and 4.00 ± 1.761 with p 0.001. The number of fibroblasts on the 14th day in the 500 mg/kgBW/day, 750 mg/kgBW/day group, positive control and negative control was 16.17 ± 3.251; 19.67±1.633; 12.17±2.137; and 8.33 ± 2.317 with p 0.001. The post hoc test found that the number of fibroblasts on day 7 significantly increased in the 500 mg/kgBB/day S. platensis group compared to the positive and negative control groups. While at a dose of 750 mg/kg/day, the number of fibroblasts was higher than the positive and negative control groups after 14 days of treatment.Administration of Spirulina platensis extract at doses of 500 and 750 mg/kg/day significantly increased the number of fibroblasts in the incision wounds of Wistar rats.
Uji Sifat Fisik pH Dan Viskositas Pada Emulsi Ekstrak Bintangur (Calophyllum soulattri Burm. F.)
Authors: Pratiwi Tiara Bella , Nurbaeti Siti Nani , Ropiqa Meri , Fajriaty Inarah , Nugraha Fajar , Kurniawan Hadi
Published: July 2023

Bintangur (Calophyllum soulattri Burm. F.) is a type of medicinal plant that has quite a lot of benefits such as antioxidant, anti-inflammatory and antibacterial, so it is important to develop it into a dosage form. Emulsions are preparations containing liquid medicinal ingredients or drug solutions dispersed in a liquid carrier. Emulsion preparations are preparations that are more easily absorbed when administered orally. Evaluation of the physical properties of the emulsion was carried out from organoleptic, pH, and viscosity parameters to produce good physical properties because they affect the resulting therapeutic effect. 150 mL of the preparation was made and evaluated for the physical properties of the organoleptic test, pH test, and viscosity test. The pH of the preparation must correspond to the pH of the oral preparation, namely 5-7, and the resulting viscosity must not be too runny or too thick because it is difficult to redisperse. The organoleptic test results of the bintangur extract emulsion had a characteristic yellow-brown color and the aroma of coconut oil with a bitter-sweet taste. The pH test results of the bintangur extract emulsion entered the range for oral preparations 5-7 with an average of 5.936 and the viscosity of the bintangur extract emulsion was 114.2 cP.
Uji Aktivitas Antibakter Formulasi Sediaan Salep Ekstrak Daun Bidara (Ziziphus mauritania) terhadap Bakteri Staphylococcus aureus
Authors: Putri Shindi Pratiwi , Samsi Al Syahril , Suriati Israini
Published: July 2023

Infectious diseases are the highest contributor to morbidity and mortality in developing countries, including Indonesia. This is inseparable from the many pathogenic bacteria that attack humans, causing various diseases. Infection due to Staphylococcus aureus, starting from the entry of bacteria through a wound scratch. Infection will be characterized by tissue damage accompanied by local abscesses such as boils or pimples. As an effort to prevent Staphylococcus aureus bacterial infection, antibacterial ointment preparations are needed that can prevent infection and are practical in their use. In this study, the antibacterial activity test of the ointment formulation of Bidara leaf extract (Ziziphus mauritania) was carried out with concentrations of 40%, 50% and 60% w/v. the test bacteria used was Staphylococcus aureus. This research was conducted using the agar diffusion method. The results showed that the test results for antibacterial ointment preparations with Bidara leaf extract with concentrations of 40%, 50% and 60% w/v fulfilled the results of the organoleptic evaluation test, homogeneity, spreadability test, adhesion test and pH test. The results of the ANOVA analysis showed that the formulation of Bidara leaf extract ointment (Zizyphus mauritania) with a concentration of 50% and 60% w/v had non-significant antibacterial activity with gentamicin sulfate ointment as a positive control against the growth of Staphylococcus aureus bacteria.
Analisis Kadar Kalsium pada Kulit Pisang Ambon dan Pisang Raja dengan Metode Spektrofotometri Serapan Atom
Authors: Margaretha Margaretha , Apridamayanti Pratiwi , Kurniawan Hadi
Published: July 2023

Indonesia is one of the countries known as the world's banana producer. Banana is one of the local fruits that are widely spread in Pontianak, West Kalimantan. Ambon banana and raja banana are classified as bananas that can be consumed directly, so banana peels are often discarded and considered as waste. Whereas banana peels are rich in nutrients such as macro and micro minerals. The purpose of this study was to determine the mineral levels of calcium in the peels of ambon banana and raja banana. Sample preparation using dry digestion method with 0.5 M HNO3 solvent. Method verification was carried out with parameters of linearity, LOD, LOQ, precision and accuracy. The assay was carried out with atomic absorption spectrophotometry at a wavelength of 422.67 nm. The results showed that the mineral levels of calcium in the wet peels of ambon banana are 104.29 mg/kg and raja banana are 314.79 mg/kg. Based on the research conducted, it can be concluded that the levels of calcium mineral in raja banana peels are higher than ambon banana peels
Narrative Review : Efek Samping Penggunaan Antibiotik Azitromycin Pada Pasien Covid-19
Authors: Dian Suryani Valentina , Umilia Purwanti Nera , Nurmainah Nurmainah
Published: July 2023

Corona virous is the cause of infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This disease was named by the World Health Organization, namely Coronavirus Disease 2019 or also known as COVID-19. In the management of COVID-19 patients using antibiotic therapy. Azithromycin is a broad-spectrum macrolide antibiotic that is the first line in the treatment of COVID- 19, because azithromycin has anti-inflammatory properties. The purpose of this study was to examine the side effects of using azithromycin as a treatment in COVID-19 patients based on a systematic review of various research articles that have been carried out. The method used is Literature review with SPIDER analysis. The results showed that azithromycin caused side effects in COVID-19 patients in the form of sudden cardiac death by triggering torsade de pointes and other ventricular arrhythmias. The conclusion is that azithromycin has been shown to cause the most side effects in COVID-19 patients.
Gambaran Praktik Five Moment Cuci Tangan Pada Perawat Di Puskesmas
Authors: Susanthy Kue Paudi Hilmawaty
Published: July 2023

The prevalence of nosocomial infections around the world is a serious concern for all health services, especially in hospitals. One of the contributing factors is non-compliance in the implementation of handwashing procedures in accordance with standard operating procedures. The study aims to determine the level of compliance of nurses in the implementation of the five-moment Handwashing at the Dungingi Health Center in 2020. The design used is obsevasional descriptive with a cross sectional approach. The total sample was 97 people taken by purposive sampling . The data analysis carried out in this study is univariate data analysts. The results of the study found that most respondents had a compliance rate of less than 69.1%, moderate compliance as much as 18.6% and good compliance as much as 12.4%. It is recommended that all nurses be more concerned about the importance of implementing the five-moment hand hygiene standard procedure, and the Puskesmas provides rewards to nurses who are obedient in implementing these standards.
Uji Toksisitas Ekstrak Etanol Kulit Terong Ungu (Solanum melongena L.) Menggunakan Metode Brine Shrimp Lethality Test (BSLT)
Authors: Dwi Cahya Nur Rahma , Abdulkadir Widy Susanti , Hasan Hamsidar
Published: July 2023

Purple eggplant skin (Solanum melongena L.) is one of the herbal plants that contain compounds such as flavonoids, alkaloids, saponnins, tannins, and terpenoids that are beneficial for health. This research is a laboratory experimental study that aims to determine the level of acute toxicity (LC50) of the ethanol extract of purple eggplant skin (Solanum melongena L.) using the Brine Shrimp Lethality Test (BSLT) method. Purple eggplant peel extraction was carried out using 70% ethanol as solvent. This test was conducted using 10 Artemia salina Leach larvae with 3 replications at 6 concentration variants, which are 500 ppm, 250 ppm, 125 ppm, 50 ppm, 25 ppm, and 12.5 ppm, along with negative controls. The larval mortality rate was observed after 24 hours of adding extract. The result of probit analysis showed that the LC50 value of the ethanol extract of purple eggplant skin (Solanum melongena L.) was 100.8 ppm. Moreover, the results of LC50 1000 ppm indicated that the ethanol extract of purple eggplant skin (Solanum melongena L.) was considered toxic and potential to be an anticancer agent.
Pengaruh Pemberian Ekstrak Kulit Pisang dan Kulit Nanas terhadap Kadar Kalium Tikus Putih Wistar
Authors: Hiqbar Hiqbar , Kurniawan Hadi , Apridamayanti Pratiwi
Published: July 2023

The waste of banana peels and pineapple peels in its utilization is still very lacking, even though it has the potential to be developed because they have high potassium as potassium intake in the body. The combination of banana peel extract and pineapple peel extract is expected to have a synergistic effect as a potassium supplement. The purpose of this study was to determine serum potassium levels of rats (Rattus norvegicus L.) Wistar with banana peel and pineapple peel extracts. Banana peel and pineapple peel were extracted using the infusion method. The test animals used male and female Wistar rats. The control group was given glucose and sucrose bases, the test group was given doses of 100, 400, and 1000 mg/KgBW of banana peel and pineapple peel extract with glucose and sucrose bases, and the control satellite group and satellite dose of 1000 mg/KgBW. The results of all groups showed normal levels of potassium in blood serum. Potassium levels between each group did not show a significant difference (p≥0.05) in male and female rats. Conclusion: administration of banana peel and pineapple peel extract did not affect the serum potassium level of Wistar rats.
Pengaruh Pemberian Kombinasi Ekstrak Kulit Pisang dan Kulit Nanas terhadap Indeks Organ Tikus Wistar
Authors: Niken Safira Melania , Apridamayanti Pratiwi , Kurniawan Hadi , Fajriaty Inarah , Nugraha Fajar , Nani Nurbaeti Siti , Pratiwi Liza
Published: July 2023

Banana peel and pineapple peel contain potassium which may be developed into health supplements. The development of banana peels and pineapple peels as ingredients for potassium supplements must meet safety aspects that can be proven by subchronic toxicity tests. This subchronic toxicity test aimed to determine the effect of repeated administration of a combination of banana peel and pineapple peel extract for 28 days on the liver, kidney, kidney, lung, heart, and spleen index of Wistar rats. This research used male and female white rats which were divided into six treatment groups, namely the control group, low dose, middle dose, high dose, satellite control, and high dose satellite. The results showed that there was a significant increase in the liver and kidney organ index, and a significant decrease in the adrenal gland organ index after administration of a combination of banana peel and pineapple peel extract. This research concludes that the combination of banana peel and pineapple peel extract has an effect on the liver, kidney, and adrenal gland organ index in Wistar white rats.
Evaluasi Kesesuaian Peresepan Obat Pada Pasien Poliklinik Penyakit Dalam Terhadap Formularium di Rumah Sakit
Authors: Sutriati Tuloli Teti , Madania Madania , Rasdianah Nur , Pramesty Gobel Indah
Published: July 2023

National formulary is a list of medicines compiled by a national committee established by the Minister of Health based on cutting-edge, efficacious, safe, and affordable scientific evidence referred for drug use by national health insurance. This study aims to determine the evaluation of drug prescribing in the Hospital formulary. This retrospective study involved subjects qualified for the inclusion criteria i.e. 73 sheet recipes in August - December 2019. some prescribed drugs that are not listed in the hospital formulary in the following percentage: August (100%), September (60%), October (50%), November (81%), and December (65%) with the average of 71%. This indicates that the prescription does not conform to the hospital formulary regulation of 100%. In conclusion, there are some drugs prescribed by the doctor that is not conformed to the hospital formulary, which means tight supervision for the prescribing is required.