bluuebunny/crossref_metadata_2025 huggingface dataset:
Descriptive Analysis Study of the Total Sugar Content of Pre-packaged Beverages Available in Saudi Arabia
Authors: Almutairi Lulu , Alammari Nouf , Alqahtani Amani
Published: March 2024

Background
Since beverages are a major source of sugar, most efforts to reduce sugar consumption focus on limiting sugary drinks. Measuring the sugar content in beverages can assist public health organizations in regulating the total and added sugar content in pre-packaged beverages, leading to better public health outcomes. Therefore, this study aims to provide a descriptive analysis of total sugar content and determine the sugar/sweetener types in a representative sample of pre-packaged beverages available in Saudi Arabia.
Methods
This is a descriptive observational analysis study of pre-packaged beverages within the Saudi branded food database. The analysis covered 12 beverage categories and 28 types of commonly available sugars in beverages. Moreover, the product's source of data, the product's origin, and the amount of total sugar and added sugar in the beverages categories were described. The beverages' median total sugar was also determined and assessed based on the World Health Organization (WHO) recommended upper limit of sugar intake and the multiple traffic light labeling (MTL) criteria. Different analyses were performed including frequencies and median to determine the categories with high sugar content and non-parametric tests to compare the median of the total sugar among categories.
Results
We included 1400 beverages in this study; the median total sugar content in beverage products in the Saudi market was 11 g/100 mL, and fruit juices and soft drinks had the highest median of total sugar 12–11g/100mL, respectively. The top sugar terms found are (Sucrose, High-fructose corn Syrup, and Glucose syrup) were found in 110 beverage products (7.8%), collectively. The median total sugar in our study amounts to 20% of the WHO upper limit recommendation for a person on a 2000-calorie diet, and 46.22% of the beverage products would receive a ‘red’ (high) label for sugar content per 100mL based on the MTL criteria.
Conclusion
Sugar content in the pre-packaged beverages is high compared to the recommended daily limit of sugar. To promote healthy dietary choices, we suggest that public health specialists launch educational campaigns to inform consumers about the risks associated with higher sugar intake and how to interpret labels effectively.
Anti-depressant like effects of Aethoscytus foveolus oil by improving stress-mediated alterations of monoamine oxidase, oxidative stress, and neuroinflammation in-vivo
Authors: Rao Lavisha , Verma Vartika , Jain Smita , Pinapati Kishore Kumar , Bhagyawant Sameer S , Sharma Swapnil , Srivast Nidhi
Published: March 2024

Background: Depression is a neuropsychological disorder with a complex pathophysiology and its pharmacotherapy is compromised with adverse side effects. Addressing the need for effective treatment for depression, the current study aims to characterize the antidepressant activity of oil extract derived from Aethoscytus foveolus, bugs that are widely available in India, in a mice model of stress-induced depression.
Approach and Results: Chemical moieties characterized by GC-MS of A. foveolus oil extract have shown good affinity for monoamine oxidase A (MAO-A) in-silico. In-vitro MAO-inhibitory assay using mouse brain homogenates also showed similar results at IC50 1.363 nM (R2=0.981, SD±0.05, n=3) of it. These results encouraged us to investigate the antidepressant potential of this oil extract in vivo. Stress-exposed mice (Swiss Albino, either sex, 25-30 gm) were administered 5 and 10 mg/kg doses of oil extract and classified as separate groups (N=6 per group). Behavioral tests like the forced-swim test, tail-suspension test, and open-field test demonstrated significant attenuation of stress-induced depressive-like behaviors in mice by both doses (p<0.0001 with positive control group i.e., stress group), while biochemical tests on mice brain tissues showed amelioration of stress-induced hyperactivation of MAO (p<0.0001) and oxidative stress (by increasing Superoxide dismutase and catalase, while reducing lipid peroxidase and nitric oxide) (p<0.0001). The altered mRNA expression of proinflammatory cytokines (NF-𝜅B, IL-6, IL-12, and TNF-α) (p<0.015) was also improved by this oil extract. In addition, histopathology of hippocampus tissues of mice supports that this oil recovers stress-mediated structural changes of the brain.
Conclusion: Our findings suggest that oil derived from A. foveolus could be beneficial in the alleviation of stress-mediated depressive-like behaviors of mice, and in our knowledge, this is the first report identifying anti-neurodegenerative potential of A. foveolus.
Targeted glomerular mesangium transfection by antifibrotic gene nanocarriers inhibits kidney fibrosis and promotes regeneration
Authors: Tai Yifan , Liu Zhen , Wang Yanrong , Zhang Xinyan , Li Ruifang , Yu Jiangyue , Chen Yao , Zhao Lili , Li Jia , Bai Xueyuan , Kong Deling , Midgley Adam C.
Published: March 2024

Renal fibrosis and loss of kidney function are key characteristics of chronic kidney disease (CKD). To address the lack of effective treatments, multifunctional layer-by-layer (LbL) assembled polymeric gene-carrier nanoparticles (PCHS-NP) are prepared to realize preferential accumulation and retention within the renal mesangium, thereby effectively leveraging cortically localized structures for the synthesis and paracrine secretion of the antifibrotic growth factor, bone morphogenetic protein-7 (BMP7). PCHS-NP have stable homogenous morphologies, kidney-targeting functionality, antioxidative effects, and high transfection efficiency. In unilateral ureteral obstruction (UUO)-induced renal fibrosis, a single systemic injection of PCHS-NP prevents tubular atrophy and interstitial fibrosis, and the resultant tissue microenvironment is more conducive to tubular regeneration driven by the upregulation of proliferative SOX9-expressing tubular cells. In longer-term folic acid (FA)-induced renal fibrosis, we show that repeat systemic injections restore kidney health and function. This study indicates that PCHS-NP accomplish a promising therapeutic option for the treatment of CKD.
Responsible Leadership: A Bibliometric Analysis
Authors: Sharma Priti , Gulia Karambir , Gupta Shivani , Sanjana
Published: March 2024

This study aims to trace the magnitude of the number of publications in the field of Responsible Leadership. This study also aims to gauge the Annual Scientific production, most relevant contributors in the field of Responsible Leadership with their citations, Author Productivity through Lotka’s Law, most relevant journals, Journal production over time, Affiliation of the country, Corresponding author's country, Keywords used in the publications with their frequency, trendy topics, collaboration network of the authors, co-citation network and Factorial analysis. The outcomes of the study not only contribute to the existing literature but also prove to be a great help in doing a Systematic Literature Review. Future research in the field will also be easy to decide with the help of this study.
Exploring psychotic experiences in borderline versus schizophrenic patients through a quali-quantitative method: The role of situational dysphoria
Authors: D'Agostino Alessandra , Gagliardi Chiara , Pagani Ariela F. , Monti Mario Rossi
Published: March 2024

Psychotic symptoms in patients with borderline personality disorder (BPD) are common, distressing, and challenging to treat. Yet, little is known about their specific characteristics. The objective of this study was to investigate psychotic experiences in borderline patients comparing them with those of psychotic patients and paying particular attention to the role of dysphoria. Two groups of adult psychiatric patients (aged 18-65 years), one with BPD and the other with schizophrenia, were administered a questionnaire assessing the presence and phenomenology of psychotic experiences (QPE), together with self-reports measuring other dimensions. Results showed that BPD patients had more heterogeneous hallucinations in terms of sensory modality, higher prevalence but lower severity of paranoid delusions, and, especially, a higher degree of situational dysphoria particularly triggered by recent interpersonal events. This suggests that psychotic symptoms in borderline patients begin to show a specific psychopathological profile, which deserves more attention from the scientific community.
The Caregiving Burden of Older People with Functional Deficits and Associated Factors on Malaysian Family Caregivers
Authors:   Department of Medical Surgical Nursing, Kulliyyah of Nursing, International Islamic University Malaysia Kuantan Campus, Pahang, Malaysia, Abdul Wahab Patimah , Abdul Talib Nurul Afiah ,   Department of Operation Theatre, Gleneagles Hospital Medini, Johor, Malaysia, Nik Mohd Hatta Nik Noor Kaussar ,   Department of Medical Surgical Nursing, Kulliyyah of Nursing, International Islamic University Malaysia Kuantan Campus, Pahang, Malaysia, Saidi Sanisah ,   Department of Medical Surgical Nursing, Kulliyyah of Nursing, International Islamic University Malaysia Kuantan Campus, Pahang, Malaysia, Abdul Mulud Zamzaliza ,   Centre for Nursing Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Selangor, Malaysia, Abdul Wahab Muhammad Nubli ,   Centre of Human Science, Universiti Malaysia Pahang, Pahang, Malaysia, Pairoh Hasanah ,   Faculty of Nursing, Prince of Songkhla University, Pattani Campus, Pattani, Thailand
Published: March 2024

Background: Providing care to older people can be an extremely complex task, given their increased functional deficits, which may lead to family caregivers experiencing burnout and a deteriorated health status. This study investigated the caregiving burden of older people with functional deficits on family caregivers and associated factors. Methods: This cross-sectional study was conducted on family caregivers of older people with functional deficits living in FELDA schemes in Pahang, Malaysia. A self-administered questionnaire was used to collect data, which included the sociodemographical profile, health status and caregiving demands factors. The caregiving burden was assessed using the Malay version of the Zarit Burden Interview (ZBI). Multiple linear regression was used to assess the factors associated with burden. Results: A total of 271 family caregivers completed the questionnaire. Their mean age was 45.8 (SD 0.9) years old. The mean score for caregiving burden was 18.5 (SD 13.6). Caregivers’ gender (3.5 [95% CI: 0.2, 6.8]; P = 0.037), older people with chronic disease (9.6 [95% CI: 2.4, 16.9]; P = 0.010) and the functional independence of older people (–1.1 [95% CI: –1.6, –0.6]; P < 0.001) were predictors of family caregiving burden. Conclusion: The caregiving burden among family caregivers was mild and influenced mainly by care recipients’ health status. A proper assessment should be conducted and relevant health education provided to prepare family caregivers to care for their family members before discharge from the hospital.
Knowledge, Attitudes and Intention to Donate Organs among the Public, Health Sciences Students and Health Personnel: A Scoping Review with a Systematic Review of Malaysian Studies
Authors:   Department of Obstetrics and Gynaecology, International Medical University, Clinical Campus, Johor, Malaysia, Saleh Emad Eldin Naguib , Jin Wei Tan ,   International Medical University, Negeri Sembilan, Malaysia, Hui Bing Lim ,   International Medical University, Negeri Sembilan, Malaysia, Annamalai Oppilal ,   International Medical University, Negeri Sembilan, Malaysia, Chii Ming Sim ,   International Medical University, Negeri Sembilan, Malaysia, Elhariri Sherreen ,   Department of Surgery, International Medical University, Negeri Sembilan, Malaysia
Published: March 2024

Background: Various barriers lead to a shortage of organs for transplantation in Malaysia. One drive to improve the organ donation rate operates through future healthcare practitioners and practitioner advocacy. This scoping review was carried out to establish and summarise findings about organ donation-related articles among the public, health sciences students and health personnel. A further aim was to synthesise the latest data on knowledge and attitudes towards organ donation in the Malaysian population. Methods: PubMed, Scopus, Google Scholar and the Malaysian Medical Repository (MyMedR) were used for a search conducted up to May 2022. Relevant search terms included ‘Organ donation’ and ‘Malaysia’. Journal articles related to knowledge, attitudes and intention were grouped under the general public and health science. Students and health personnel were included. Eligible studies were reviewed by two independent reviewers. Any disagreements were resolved by consensus with a third reviewer. Results: The 31 included articles revealed an increased level of awareness among the public regarding organ donation. The analysis identified that nonrecognition of brainstem death (38.5%), no knowledge of how to contact the Organ Transplant Coordinator (82.3%) and never approaching the families of a potential donor (63.9%) led to a lack of confidence among healthcare practitioners to promote organ donation. Conclusion: The shortage of organ donors is the result of the failure to identify the expected donor, obtain consent and procure the organs due to the passivity of Malaysian health professionals in promoting the organ donation process.
Does the Difference in Axial Length Affect the Refractive Outcome?
Authors:   Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Saidi Noor Amalina , Abdul Karim Nur Syahirah ,   Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Ismail Adawiyah ,   Department of Ophthalmology Hospital Sultanah Nur Zahirah, Terengganu, Malaysia, Raja Othman Raja Nor Farahiyah ,   Department of Ophthalmology Hospital Sultanah Nur Zahirah, Terengganu, Malaysia, Ahmad Kasah Nor Higrayati ,   Department of Ophthalmology Hospital Sultanah Nur Zahirah, Terengganu, Malaysia, Yaakub Azhany ,   Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Zhe Ngoo Qi ,   Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
Published: March 2024

Background: The purpose of this study is to compare axial length (AL) and the refractive outcome after phacoemulsification surgery from 2014 to 2019 at Hospital Sultanah Nur Zahirah, Terengganu, Malaysia. Method: This was a retrospective record review of all cataract patients who met the inclusion criteria and underwent uneventful superior wound phacoemulsification with nontoric intraocular lens (IOL) by a single surgeon from 2014 to 2019. Using optical biometry or immersion technique, the preoperative AL determined solely via the Sanders, Retzlaff and Kraff 2 (SRK2) formula was selected. The postoperative spherical equivalent (SE) at 6 weeks–12 weeks was retrieved. Using Statistical Package for the Social Sciences version 24.0, the mean differences between targeted and actual postoperative SE were analysed based on the AL. Result: In this study, 490 eyes of 472 patients aged 25 years old–88 years old (mean age 65.72 years old [SD 8.83]) were involved. There were 162 eyes (33%) in Group A (< 23 mm), 189 eyes (39%) in Group B (23.01 mm–24.0 mm) and 139 eyes (28%) in Group C (> 24.0 mm). The mean AL was 23.63 mm (SD 1.19). The mean differences between the targeted and actual postoperative SE were: −0.09 D (SD 0.60) in Group A, −0.07 D (SD 0.53) in Group B and −0.16 D (SD 0.52) in Group C. No significant difference was found between these groups (P = 0.327). Conclusion: There was no significant difference in the refractive outcome using the SRK2 formula in different ALs after phacoemulsification surgery. Hence, there is no reason to modify or adjust the targeted SE based on AL.
Codebase release r1.4 for CoVVVR
Authors: Shyamsundar Prasanth , Scott Jacob L. , Mrenna Stephen , Matchev Konstantin T. , Kong Kyoungchul
Published: March 2024

Monte Carlo (MC) integration is an important calculational technique in the physical sciences. Practical considerations require that the calculations are performed as accurately as possible for a given set of computational resources. To improve the accuracy of MC integration, a number of useful variance reduction algorithms have been developed, including importance sampling and control variates. In this work, we demonstrate how these two methods can be applied simultaneously, thus combining their benefits. We provide a python wrapper, named COVVVR, which implements our approach in the VEGAS program. The improvements are quantified with several benchmark examples from the literature.
A szociálisprobléma-megoldás, a megküzdési stratégiák és az asszertív kommunikáció jellemzői 10-11 évesek körében
Authors: Balogh-Pécsi Anett
Published: March 2024

A szociálisprobléma-megoldás a társas probléma megoldására irányuló motivációs-kognitív-érzelmi-viselkedéses folyamat, mely nagymértékben befolyásolja az egyének negatív helyzettel való megküzdését, amiben szintén meghatározó szerepet játszik az egyén kommunikációs stílusa. A kommunikációs stílusok (asszertív, agresszív, szubmisszív, passzív-agresszív) azonosítása és tudatosítása nagymértékben hozzájárul a problémahelyzetek felismeréséhez, ezáltal számos konfliktus megelőzhető. A tanulmányban ismertetjük a 10-11 évesek körében (N=182) végzett mérés eredményeit, melynek célja a szociálisprobléma-megoldás, az asszertív kommunikáció és a megküzdési stratégiák jellemzőinek és azok kapcsolatainak feltárása volt, fókuszálva a lányok és fiúk közötti eltérésekre, hiszen számos korábbi kutatás alapján a nem szerinti jellemzők szoros kapcsolatot mutatnak több háttérváltozóval és személyiségjellemzővel. Az eredmények alapján inkább a lányokra jellemző, hogy problémáikhoz pozitívan viszonyulnak, egyúttal igyekeznek a tényekre koncentráltan és asszertív kommunikációs eszközökkel megoldani társas problémáikat. Az elkerülő megoldói stílust mutatókra jellemző leginkább a passzív vagy a szubmisszív kommunikációs stílus, ami a fiúk körében gyakoribb. Mivel a nemek közötti különbségek azonosítása a fejlesztéseket megelőző kutatásoknak is az egyik kiemelt célja, a kutatás eredményei hozzájárulnak a kommunikációalapú szociálisprobléma-megoldást, illetve a megküzdést fejlesztő programok kidolgozásához.
The contemporary political elite of Central and South-Eastern European countries: Personalities and general trends (reflecting on a recent book)
Authors:   St. Petersburg State University, Khudoley Konstantin K.
Published: March 2024

The purpose of the article is to study the state of the modern political elite in the countries of Central and South-Eastern Europe, to identify the main trends in its development and the role of personal factors based on the analysis carried out by the authors of the collective monograph of the Institute of Slavic Studies of the Russian Academy of Sciences. Generally, the transition in Central European countries from socialism to capitalism successfully took place, and the line of integration into the Western world prevailed. However, among the countries’ ruling circles, there are both supporters of total acceptance of the rules established in Brussels and those who seek to preserve greater independence for their countries within European and Euro-Atlantic structures. These contradictions are serious but surmountable due to the already established political institutions in these countries and some experience of political compromises. In South-Eastern Europe, the transition to capitalism was more complex, accompanied by acute national conflicts. It is currently complicated by a de facto suspension of these countries’ accession to the EU. The result is a more diverse composition of the elite in this region compared to Central Europe — former communists, military men, and nationalists are significantly more numerous here. The situation is aggravated by the weakness of political institutions and the elites’ inability, and sometimes unwillingness, to seek solutions to problems through compromises. Particularly noteworthy are the biographies of R. Erdogan and A. Tsipras, who tried (the first successfully, the second not) to implement radical changes in the political life of their countries. Politicians from all considered countries focusing on national characteristics and traditional values generally have significant potential. It would be advisable for Russia to analyze the successes and failures in relations with the Central and South-Eastern European countries in recent decades and learn from this experience for future policy.
Natural diet of the Southern king crab Lithodes santolla (LITHODIDAE) in the Beagle Channel, Tierra del Fuego, Argentina
Authors: Comoglio Laura Inés , Amin Oscar Antonio
Published: March 2024

Stomach contents of 320 Southern king crabs (Lithodes santolla) ranging from 40 mm to 100 mm in carapace length (CL) from Beagle Channel, near Ushuaia city, Argentina, were examined by the frequeney of occurrence method of analysis and by the relative weight of stomach content. Of the total number of the crabs contained food (77.19%) 24 were damaged, so that they were excluded of the analysis. Molluscs (mainly gastropods) dominated in terms of frequeney of occurrence; crustaceans and bryozoa were the second-and third- most important groups, respectively. The relativo frequeney of different prey groups varied in relation to the size class and season. No significant differences in the quantity of relativo weight of food was observed between sexes, but significant differences were detected in the quantity' of food consumed from different seasons and size groups. Consumption was greatest during winter in crabs <70 mm (CL). Generally small crabs (<60 mm CL contained more food than did large crabs (>70 mm CL).
Variaciones mensuales en el asentamiento de semilla de cholga (Aulacomya atra atra MOLINA) sobre colectores artificiales en el golfo de San José, Argentina.
Authors: Lizarralde Zulma I.
Published: March 2024

En el presente trabajo se analizan los cambios mensuales en el asentamiento de semilla de cholga (Aulacomya atra atra Molina) en el golfo San José (Argentina, 42°20’S, 64°30’ W) y de las incrustaciones biológicas asociadas a los colectores. El colector utilizado consistió en una red de 11,02 mm de abertura de malla, de 1 m de largo x 0,30 m de ancho. Los colectores permanecieronsumergidos por dos meses, entre septiembre de 1987 y agosto de 1989. Los juveniles se asientan durante todo el año, con un pico máximo en primavera. La talla promedio de los individuos asentados fue durante el periodo estudiado < 2 mm. El ciclo de variación anual de las incrustaciones biológicas registró un pico máximo en los meses de primavera y verano.
Hábitos alimentarios de la Raya Urotrygon asterias en la costa de Jalisco y Colima, México.
Authors: Valadez-González Carmen
Published: March 2024

Se capturó un total de 537 ejemplares of Utotrygon asterias (Jordán y Gilbert, 1982) en la costa de Jalisco y Colima México, en muéstreos mensuales desde septiembre de 1997 hasts agosto de 1998, de los cuales se analizaron 302 estómagos y se descartaron 235 por estar vacíos. De acuerdo con el Indice de Importancia Relativa (IIR), esta especie se elimentó principalmente de estomatópodos del género Squilla (Latreille, 1803) y Eurysquilla veleronis (Schmitt, 1940), los decápodos Ogyrides alphaerotris (Holthuis, 1955), Processa peruviana (Ortmann, 1890) y peces intdeterminados. Se encontró una variación de la alimentación a lo largo del año y con respecto a la talla de los organismos analizados.
Implementation of the empowerment model of female laborers on Arabica coffee processing industry in Bangli Regency, Bali Province
Authors: Astiti Ni Wayan Sri , Darmawan Dwi Putra
Published: March 2024

The Model Analytic Hierarchy Process (AHP) selection of the female laborers' empowerment strategy at UPH which refers to the results of the SWOT analysis shows that strengthening the competence of women laborers' is the main priority of empowerment as a solution to gap performance of female laborers' in the arabica coffee processing industry in Bali. Based on the model, the purpose of this research is to increase the capability of female laborers. The search for female laborers' empowerment needs using the method of appreciative inquiry, through (a) rapid research involving multidisciplinary teams; (b) in-depth interviews and direct observation; (c) Interactive Management sessions; (d) peer review. The main results of the implementation of strategies for strengthening female laborers capability in UPH Kintamani Indonesia are (a) achievement of capability outcome in technical and production management and processing, as well as in UPH institution management; (b) documents of infrastructure development needs in the UPH and roadmap of UPH development documents, SOPs (machine utilization and added value enhancements), and regulations on strategic partnership arrangements. Empowerment of female laborers in UPH Kintamani Indonesia needs to be continuously evaluated and the results are followed up to produce premium-quality Arabica coffee production processed in accordance with IG certification, supported by distinctive product design innovations to support business independence and partnership contract sustainability.
Dr. Agro Aliado del asistente técnico agropecuario.
Authors:   Corporación Colombiana de Investigación Agropecuaria, Mosquera (Colombia)
Published: March 2024

El Dr. Agro es una herramienta de bolsillo que apoya la toma de decisiones de los Asistentes Técnicos Agropecuarios (ATA), en el reconocimiento, manejo y control de agentes causales en diferentes cultivos del país. Esta aplicación se encuentra disponible en las tiendas App Store o Google Play para su descarga a través de Internet.
Intention to Use an Electronic Community Health Information System Among Health Extension Workers in Rural Northwest Ethiopia: Cross-Sectional Study Using the Unified Theory of Acceptance and Use of Technology 2 Model (Preprint)
Authors: Hailemariam Tesfahun , Atnafu Asmamaw , Gezie Lemma , Kaasbøll Jens , Klein Jorn , Tilahun Binyam
Published: March 2024

BACKGROUND

IT has brought remarkable change in bridging the digital gap in resource-constrained regions and advancing the health care system worldwide. Community-based information systems and mobile apps have been extensively developed and deployed to quantify and support health services delivered by community health workers. The success and failure of a digital health information system depends on whether and how it is used. Ethiopia is scaling up its electronic community health information system (eCHIS) to support the work of health extension workers (HEWs). For successful implementation, more evidence was required about the factors that may affect the willingness of HEWs to use the eCHIS.

OBJECTIVE

This study aimed to assess HEWs’ intentions to use the eCHIS for health data management and service provision.

METHODS

A cross-sectional study design was conducted among 456 HEWs in 6 pilot districts of the Central Gondar zone, Northwest Ethiopia. A Unified Theory of Acceptance and Use of Technology model was used to investigate HEWs’ intention to use the eCHIS. Data were cleaned, entered into Epi-data (version 4.02; EpiData Association), and exported to SPSS (version 26; IBM Corp) for analysis using the AMOS 23 Structural Equation Model. The statistical significance of dependent and independent variables in the model was reported using a 95% CI with a corresponding P value of <.05.

RESULTS

A total of 456 HEWs participated in the study, with a response rate of 99%. The mean age of the study participants was 28 (SD 4.8) years. Our study revealed that about 179 (39.3%; 95% CI 34.7%-43.9%) participants intended to use the eCHIS for community health data generation, use, and service provision. Effort expectancy (β=0.256; P=.007), self-expectancy (β=0.096; P=.04), social influence (β=0.203; P=.02), and hedonic motivation (β=0.217; P=.03) were significantly associated with HEWs’ intention to use the eCHIS.

CONCLUSIONS

HEWs need to be computer literate and understand their role with the eCHIS. Ensuring that the system is easy and enjoyable for them to use is important for implementation and effective health data management.
Decomposition of post-coordinated SNOMED CT expressions for storage as HL7 FHIR resources (PCEtoFHIR) (Preprint)
Authors: Ohlsen Tessa , Drenkhahn Cora , Ingenerf Josef
Published: March 2024

BACKGROUND

To guarantee interoperability, structural and semantic standards must be adhered to. For exchanging medical data between information systems, the structural standard FHIR (Fast Healthcare Interoperability Resource) is recently gaining traction. In terms of semantic interoperability, the reference terminology SNOMED CT as a semantic standard enables a post-coordination in comparison to many other vocabularies. These post-coordinated expressions (PCEs) result in SNOMED CT being an expressive and flexible interlingua, which enables precise coding of medical facts, but at the expense of increased complexity and challenges with storage and processing. In addition, the boundary between the scope of semantic (terminology) and structural (information model) standards blurs, the so-called TermInfo problem.

OBJECTIVE

Although often discussed critically, the TermInfo overlap can also be explored for its beneficial potential by enabling a flexible transformation of parts of the PCEs. In this paper, an alternative solution for the storage of PCEs is presented, i. e., in combination with the FHIR data model. In the end, all components of a PCE should be expressible exclusively by pre-coordinated concepts that are linked to suitable elements of the information model.

METHODS

The approach is based on storing PCEs and/or parts of them conforming to FHIR resources. Using the Web Ontology Language for generating an OWL ClassExpression in combination with an external reasoner and semantic similarity measures, a pre-coordinated SNOMED CT concept that describes the PCE most precisely is determined as a superconcept. In addition, the non-matching attribute relationships between the superconcept and the PCE are determined as the so-called delta. Once SNOMED CT attributes have been mapped to FHIR elements manually, FHIRPath expressions can be determined for the superconcept and the delta, which in turn enable the identified pre-coordinated codes to be stored in FHIR resources.

RESULTS

A web application called PCEtoFHIR was developed to implement this approach. In a validation with 600 randomly selected pre-coordinated concepts, the correctness of the generated OWL ClassExpression could be confirmed. Additionally, two different approaches for calculating semantic similarities were validated, with the approach by Sanches et al. demonstrably yielding more precise results. In a validation of the entire approach, considering 33 already existing PCEs, the correct functionality could also be demonstrated.

CONCLUSIONS

PCEtoFHIR provides services to decompose PCEs for storing them in FHIR resources. When creating structure mappings concerning certain subdomains of SNOMED CT concepts (e.g. allergies) to desired FHIR profiles, the use of SNOMED CT Expression Templates has proven to be very useful. Domain experts can prepare templates with suitable mappings that can be reused in a constrained way by end users more easily.
Participation of Social Organizations in Urban Social Governance: Realistic Dilemma and Optimization Path
Authors: Li Chao
Published: March 2024

In order to promote the modernization of social governance, we cannot ignore the indispensable role of social organizations in urban social governance. Affected by factors such as backward value cognition, weak supervision mechanism, weak service ability and insufficient resource support, the role of social organizations has not been fully brought into play. In order to solve the problem of function output of social organizations in municipal social governance, it is necessary for the government, society and social organizations to form a joint force, commit to updating the value concept of social organizations, improve the supervision system of social organizations, pay attention to the capacity building of social organizations and strengthen multi-channel resource support, so that social organizations can better participate in municipal social governance.
DRUG-INDUCED CUTANEOUS REACTIONS: A PHARMACOVIGILANCE STUDY
Authors: DUA MITALI , NARWAT ARVIND , GOYAL ABHINAV
Published: March 2024

Objective: Drug-induced cutaneous reactions are common problem in our country and can range from simple rash to severe reactions. Early recognition of these reactions enables early identification and withdrawal of offending drugs, thereby reducing morbidity and mortality. So present study aimed to assess clinical pattern of drug-induced cutaneous reactions in Dermatology OPD. Methods: This study was an open, non-comparative, non-interventional, observational study conducted on patients visiting dermatology department to see the clinical pattern of drug-induced cutaneous reactions. A total of 60 patients with suspected cutaneous adverse drug reactions were recruited. A detailed physical examination was done by a physician, including drug intake during 3 w preceding reactions and type of drug reactions. Results: Most frequently reported cutaneous drug reactions were Stevens-Johnson Syndrome (23%), Maculopapular rash (18%) Toxic Epidermal Necrolysis (15%) and were caused by antiepileptic drugs in 21(35%) patients, followed by antibiotics in 17(28.33%) cases, NSAID’s in 7(11.6%) cases, antitubercular drugs in 3(5%) and antiretroviral drugs in 3(5%) cases. A high proportioned of these reactions (50%) were moderate (31%) of these were severe because they require hospitalisation or increased the duration of stay in hospital or were life-threatening in (1%). Principal offending drug was phenytoin. Conclusion: A good knowledge of ADRs, a careful history taking and watchful approach while prescribing of drugs can prevent many of adverse drug reactions. These facts justify the development of an intensive programme of pharmacovigilance.
HAEMATO-BIOCHEMCIAL STUDIES OF NANOPARTICLE-BASED VACCINE AGAINST R2B STRAIN OF NEW CASTLE DISEASE IN CHICKS
Authors: TOMAR RUHI , YADAV SHIVANI , CHAUHAN DUSHYANT K.
Published: March 2024

Objective: The goal of the current study is to create a Newcastle disease vaccine based on green synthesised metal oxide nanoparticles and to study the haematological and biochemical effects of this vaccine in chicks.
Methods: Copper Oxide Nanoparticles (CuONPs) from Momordica charantia were synthesised biologically. These copper oxide nanoparticles were combined with a commercially available freeze-dried Newcastle Di0sease (ND) vaccination of the live R2B strain to use it as a vaccine delivery method in the current work. Haematological and biochemical parameters were investigated in pre-challenged and post-challenged chicks.
Results: After the injection of copper nanoparticles-based vaccines, it was found that the pre-challenged animals and post challeneged animals showed highly significant difference (P<0.05) in their total White Blood Cells (WBC) counts, hemoglobin concentration, hematocrit value, and Erythrocyte Sedimentation Rate (ESR) in comparison to control and live vaccinated groups. It was also investigated that for biochemical parameters After the injection of copper nanoparticles-based vaccines, both pre-challenged animals and post challeneged animals showed highly significant difference (P<0.05) in their blood glucose level, serum total protein, creatinine, serum alkaline phosphatase, Aspartate Amino Transferase (ALT) and Alanine Amino Transferasse (AST) in comparison to control and live vaccinated groups.
Conclusion: The vaccine not only makes chicks healthier, but also shields them from the virus that causes Newcastle disease
AI-enabled cancer target prioritization with optimal profiles balancing novelty, confidence and commercial tractability
Authors: Long Xi , Steurer Barbara , Wong Chun Wai , Kozlova Ekaterina , Naumov Vladimir , Pun Frank W , Aliper Alex , Ren Feng , Zhavoronkov Alex
Published: March 2024

The identification of new biological targets is crucial to advance cancer therapy, but deciphering the fiendishly complex processes that drive and sustain disease can be tedious and resource intensive. To optimize and accelerate the drug discovery process, artificial intelligence (AI) platforms are emerging that enable fast and cost-effective identification and prioritization of novel and disease-specific therapeutic targets with optimal target profiles, balancing confidence, novelty and commercial tractability. AI-streamlined target profiling has the potential to significantly improve the commercial burden of traditional drug development, and provides an unbiased approach for novel target identification. Here, we discuss the AI-assessed target profile and clinical relevance of genes recently identified by our AI-driven target discovery platform as top priority cancer targets.
Alcances e importancia de la cadena de valor como herramienta de diagnóstico y análisis para micro y pequeños negocios gastronómicos
Authors: Mendoza Acevedo Mariana , López Ojeda Andrés
Published: March 2024

Objetivo: analizar los alcances y la importancia de la cadena de valor aplicada a los micronegocios gastronómicos en el Estado de México para saber cuáles son los elementos que dan ventaja competitiva. Metodología: exploratoria, etnográfica y analítica, derivada del trabajo de campo in situ y de un seminario taller. Resultados: se comprobó la pertinencia y la utilidad del modelo aplicado a pequeños emprendimientos del sector de servicios. Se observaron valores compartidos y diferencias. Limitaciones: debido al carácter cualitativo del trabajo, los emprendimientos que se analizaron son singulares, por lo que los resultados no son generalizables. Conclusiones: el modelo es pertinente y de incidencia positiva en este tipo de negocios, debido al aprovechamiento del patrimonio gastronómico regional como elemento diferenciador del resto de la oferta actual, como la comida ultraprocesada. Se requieren indicadores contextualizados para la gestión eficiente de esos ecosistemas. El valor compartido demuestra la importancia de las decisiones para hacer eficientes los recursos y asegurar la permanencia en los mercados.
INDIKATOR HISTOPATOLOGI PENCEMARAN AIR PADA INSANG IKAN NILA (Oreochormis niloticus L)
Authors: Mandia Sayati , Susanti Silvi , Maharani Ade Dewi
Published: March 2024

Tujuan penelitian ini adalah untuk melihat efek pencemaran perairan terhadap ikan melalui observasi preparat histologis insang ikan nila (Oreochormis niloticus L). Penelitian dilakukan pada Bulan Januari 2017. Jenis penelitian ini adalah penelitian kualitatif menggunakan metode observasi langsung terhadap struktur insang ikan nila. Teknik pengambilan sampel adalah purposive sampling pada 3 lokasi di Danau Maninjau. Pembuatan preparat menggunakan metode paraffin dan pewarnaan Haematoxylin-Eosin di Laboratorium Balai Veteriner, Bukittinggi. Hasil pengamatan struktur histologi insang menunjukkan adanya perubahan struktur histologi berupa hipertropi, fusi lamella, kerusakan struktur lamella hingga hilangnya struktur lamella. Dapat disimpulkan bahwa efek pencemaran perairan dapat mengakibatkan perubahan terhadap struktur histologi insang ikan nila.
WILD PTERIDOPHYTA THAT CAN BE USED AS DECORATIVE PLANTS BY THE SOCIALITY
Authors: Nursyahra Nursyahra , Putri Lola Dwi , Zural Mimin Mardhiah , Meriko Lince
Published: March 2024

Abstract. Fern is a plant that is spread so widely that it can be found from the lowlands to the highlands, has a high diversity of Indonesian flora groups and many grow in moist areas such as oil palm plantations, forests, hills and even river flows. In the river there are fern plants that grow attached to the stone. The study was conducted in July-August 2019 and aims to find out the types of fern plants that are used as decorative plants by sociality. The method used in this study is a descriptive survey by field observation and direct collection. Collections obtained were identified using with plant taxonomy books and field guides. Analysis of research data was done descriptively. The results showed that there were 6 types of decorative fern plants consisting of 1 class, 1 nation, 5 tribes, and 6 clans.Keywords: Pteridophyta, The Benefits of Fern
GAYA BELAJAR DAN HUBUNGANNYA DENGAN HASIL BELAJAR BIOLOGI SISWA MADRASAH ALIYAH NEGERI DI ERA COVID- 9
Authors: Gusmaweti Gusmaweti , Susanti Wilda
Published: March 2024

This study aims to describe learning styles and their relationship to biology learning outcomes for students of class XI IPA Madrasah Aliyah Negeri (MAN) in the era of covid-19. This type of research is descriptive quantitative research. The learning styles studied include visual, auditory and kinesthetic learning styles. Sampling was done by total sampling with a total sample of 68 students of class XI IPA. The research instrument was a questionnaire on the types of student learning styles that were valid and reliable. The results of the validity test of the questionnaire by two validators were 3.25 and 3.00, respectively, with a valid and appropriate category for use, and the results of the questionnaire reliability test were obtained at 0.66 with a fairly high interpretation. The results showed that the overall student learning style was kinesthetic by 41%; auditory 30% and visual 29%, the highest learning style is kinesthetic. There is a positive relationship between learning styles and student biology learning outcomes. It can be concluded that the higher the percentage of learning styles, the higher the students biology learning outcomes. The results of this study provide information to teachers to use appropriate and varied strategies and methods as well as learning media during the learning process.
THE INFLUENCE OF WHATSAPP GROUP-BASED BLENDED LEARNING ON STUDENTS' CRITICAL THINKING ABILITIES
Authors: Herlina Meti , Lubis Rukiah , Fitriyani Nesti
Published: March 2024

This research aims to determine the influence of WhatsApp Group-based Blended Learning on students' critical thinking abilities. The study adopts a quasi-experimental design and is conducted at SMAN 8 Seluma. The sample consists of Class XII MIPA 1 as the experimental group receiving blended learning treatment, and Class XII MIPA 2 as the control group undergoing conventional learning. The Statistics Group Pretest-Posttest design is employed. Non-Probability Sampling is used for sample selection, and data analysis is performed using the t-test. The research findings reveal a significant difference in students' critical thinking abilities between the experimental and control groups. The average critical thinking ability score for the experimental group is 49.55, while for the control group, it is 46.43. The t-test results indicate a significance level of Sig. (2-tailed) = 0.000 < 0.05, and Tcount (calculated t-value) = 5.668 > Ttable (critical t-value) = 2.022 (sig: 5.668 > 2.022). Therefore, H1 is accepted, and H0 is rejected, leading to the conclusion that WhatsApp Group-based Blended Learning has a significant influence on students' critical thinking abilities.
PENGEMBANGAN LEMBAR KERJA SISWA (LKS) BERBASIS REALISTIK PADA MATERI SEGI EMPAT
Authors: Aima, M.Pd Zulfitri , Suryani Mulia , Nita Afrili
Published: March 2024

Penelitian ini dilandasi oleh penggunaan bahan ajar yang kurang efisien dan guru menjelaskan menggunakan powerpoint yang belum memberikan kesempatan kepada siswa untuk mengkonstruksikan pemahamannya sehingga hasil belajar siswa rendah pada materi segi empat. Selain itu, siswa juga belum dituntun untuk menemukan sendiri suatu konsep dan mengaitkannya dalam kehidupan sehari-hari.Upaya untuk mengatasi masalah tersebut adalah dengan mengembangkan bahan ajar berupa LKS berbasis realistik. Penelitian ini bertujuan untuk menghasilkan LKS berbasis realistik pada materi Segi Empat yang valid di kelas VII MTsN Kuranji Kota Padang. Penelitian ini merupakan penelitian pengembangan yang menggunakan rancangan Plomp yang terdiri atas tahap preliminary research dan prototyping phase. Metode evaluasi yang digunakan mengacu kepada rancangan evaluasi formatif yang terdiri atas evaluasi diri dan tinjauan ahli. Penelitian ini menghasilkan produk berupa LKS berbasis realistik pada materi segi empat dalam pembelajaran matematika. LKS ini dinyatakan sangat valid dengan nilai validitas 84,85 % oleh validator baik dari segi aspek kelayakan isi, penyajian, kebahasaan dan kegrafikaan.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE TEAM ASSISTED INDIVIDUALIZATION UNTUK MENINGKATKAN PEMAHAMAN KONSEP MATEMATIS SISWA
Authors: Mardiyah Ainil , Muslim Audra Pramitha , Syari Engla Devia
Published: March 2024

Penelitian ini dilatarbelakangi oleh pemahaman konsep matematis siswa yang masih rendah dan tingginya sikap individual siswa yang berkemampuan tinggi. Tujuan penelitian ini yaitu untuk mengetahui apakah pemahaman konsep matematis siswa dengan penerapan model pembelajaran kooperatif tipe Team Assisted Individualization (TAI) lebih baik daripada kemampuan pemahaman konsep matematis siswa dengan menerapkan pembelajaran konvensional siswa kelas XI IPA SMAN 2 Bayang. Jenis penelitian ini adalah penelitian eksperimen dengan rancangan penelitian random terhadap subjek. Populasi penelitian ini adalah siswa kelas XI IPA SMAN 2 Bayang yang terdiri dari lima kelas. Teknik pengambilan sampel dilakukan secara acak, dimana kelas XI IPA 4 sebagai kelas eksperimen dan kelas XI IPA 5 sebagai kelas kontrol. Instrumen yang digunakan adalah tes akhir yang berbentuk esai dengan reliabilitas 0,76. Berdasarkan tes akhir yang diperoleh, kedua kelas sampel berdistribusi normal dan homogen. Statistik uji yang digunakan untuk pengujian hipotesis penelitian adalah uji t satu pihak dengan thitung = 1,79 dan ttabel = 1,67 karena thitung  > ttabel maka hipotesis diterima. Sehingga dapat disimpulkan pemahaman konsep matematis siswa dengan penerapan model pembelajaran kooperatif tipe TAI  lebih baik daripada pemahaman konsep matematis siswa dengan menerapkan pembelajaran konvensional siswa kelas XI IPA SMAN 2 Bayang.
Android-Based Learning Media Using MIT App Inventor on Algebra Materials for Junior High School Student
Authors: Amri Arif Rahman , Anggraini Villia , Fitri Dewi Yuliana
Published: March 2024

During the Covid-19 pandemic, the learning system in Indonesia was carried out online. In the context of learning mathematics for junior high school students, especially algebra material, this online learning system makes students confused and do not focus on the learning material. As a result, students are unable to answer or complete or solve the algebra problems given. This situation then has a big impact on learning outcomes. For that reason, this research propose Android-Based Learning Media using MIT App Inventor on Algebra Materials. This research designed as part of development which conducted the assessment phase. Based on data analysis, it can be concluded that Android-Based Learning Media using MIT App Inventor on Algebra Materials obtained a value of 89.67% with the valid category from the expert, practicality test results scored 82.44% students with very practical categories. As the conclusion the android-based MIT App Inventor learning media on algebra material is appropriate for use in the learning process.