bluuebunny/crossref_metadata_2025 huggingface dataset:
Boosting Mitochondrial Potential: An Imperative Therapeutic Intervention in Amyotrophic Lateral Sclerosis
Authors: Dhasmana Swati , Dhasmana Anupam , Kotnala Sudhir , Mangtani Varsha , Narula Acharan S. , Haque Shafiul , Jaggi Meena , Yallapu Murali M. , Chauhan Subhash C.
Published: September 2022

Background:

Amyotrophic Lateral Sclerosis (ALS) is a progressive and terminal neurodegenerative disorder. Mitochondrial dysfunction, imbalance of cellular bioenergetics, electron chain transportation and calcium homeostasis are deeply associated with the progression of this disease. Impaired mitochondrial functions are crucial in rapid neurodegeneration. The mitochondria of ALS patients are associated with deregulated Ca2+ homeostasis and elevated levels of reactive oxygen species (ROS), leading to oxidative stress. Overload of mitochondrial calcium and ROS production leads to glutamatereceptor mediated neurotoxicity. This implies mitochondria are an attractive therapeutic target.

Objective:

The aim of this review is to brief the latest developments in the understanding of mitochondrial pathogenesis in ALS and emphasize the restorative capacity of therapeutic candidates.

Results:

In ALS, mitochondrial dysfunction is a well-known phenomenon. Various therapies targeted towards mitochondrial dysfunction aim at decreasing ROS generation, increasing mitochondrial biogenesis, and inhibiting apoptotic pathways. Some of the therapies briefed in this review may be categorized as synthetic, natural compounds, genetic materials, and cellular therapies.

Conclusion:

The overarching goals of mitochondrial therapies in ALS are to benefit ALS patients by slowing down the disease progression and prolonging overall survival. Despite various therapeutic approaches, there are many hurdles in the development of a successful therapy due to the multifaceted nature of mitochondrial dysfunction and ALS progression. Intensive research is required to precisely elucidate the molecular pathways involved in the progression of mitochondrial dysfunctions that ultimately lead to ALS. Because of the multifactorial nature of ALS, a combination therapy approach may hold the key to cure and treat ALS in the future.
Association between Some Helminths and Tumorigenesis through
Immunological and Biochemical Factors
Authors: Fasihi-Karami Maryam , Afrisham Reza , Karami Saina , Beigzadeh Ehsan , Kazemi Forough
Published: September 2022

It has been reported that more than 20% of malignancies in the developing countries are
induced by some infections. However, helminth infections related to malignancies have been less
appreciated. Since, helminths sometimes infect their hosts for over decades, the host’s immune responses
get modulated Several studies have shown that there are many similarities between the persistence
of parasite infection and the progression of tumors in terms of biochemical and immune
responses. Thus, this review was designed to evaluate the association between some helminths and
tumorigenesis through immunological and biochemical factors. The results of the current study
showed that helminth infections could be implicated in the pathogenesis of some cancers. Several
factors contribute to tumorigenesis of these helminth-stimulated tumors. These helminth infections
increase the proportions of CD19+ B cells and F4/80+ macrophages as well as reduce the proportions
of CD8+ lymphocytes, and increase the levels of VEGF, IL-10, and IL-4. In addition, this parasitestimulated
inflammation may encourage neoplasia. Also, catechol-estrogens and oxysterols related to
some helminths can play a key role in tumorigenesis. Thus, the effects of parasitic helminth infections
on the development of tumor are very important. However, the investigation on these issues
requires further study, which can be helpful in preventing parasitic helminth infections-related cancers.
Strategies for the Separation and Quantification of Non-Steroidal Anti-
Inflammatory Drugs Using ZIC-HILIC-HPLC with UV Detection
Authors: Rasheed Ashraf S. , Waheb Ali Amer , Hassan Mohammed Jasim M.
Published: September 2022

Background:

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used
worldwide for their analgesic, anti-inflammatory, and antipyretic properties.

Objective:

The article highlights the development of zwitterionic hydrophilic interaction liquid
chromatography (ZIC-HILIC) methods to quantify three NSAIDs as active ingredients in pharmaceutical
formulations simultaneously.

Method:

For NSAIDs analysis, two homemade ZIC-HILIC stationary phases were carried out by
adding sulfobetaine monomers to polystyrene-divinylbenzene particles. The methods were developed
by examining the effect of HILIC mode parameters like the kind of organic modifier (methanol
or acetonitrile), acetonitrile content, pH and concentration of the acetate buffer in the eluent.

Results:

The experimental data exhibit the predominant mechanism of NSAIDs with two ZICHILIC
stationary phases. The different chain lengths in the two ZIC-HILIC stationary phases are
employed to investigate NSAIDs retention behaviour. The strategies were evaluated for their
specificity, linearity, accuracy, and precision. The linear ranges were 0.01-5.0, 0.05-17.5 and
0.12-13.5 μg ml-1, LOD 0.005. 0.015 and 0.046 μg ml-1 and LOQ 0.015, 0.045 and 0.139 μg ml-1
for nimesulide, tenoxicam and diclofenac, respectively.

Conclusion:

They represent interactions with three NSAIDs, ZIC-HILIC columns, and mobile
phase in a mixed-mode of hydrophilic and hydrophobic interactions. In contrast to the ZICHILIC-
1 stationary phase with a shorter chain length, the ZIC-HILIC-4 stationary phase with a
longer chain length exhibited a longer retention time, lower detection and limit of quantitation for
three NSAIDs.The verification findings demonstrate the suitability of the proposed ZIC-HILIC
methods for quantifying NSAIDs in pharmaceutical formulations.
27-21
Authors: Krasnoshchekov S.V.  , Gainullin I.K.  , Laptev V.B.  , Klimin S.A.
Published: September 2022

The IR transmittance spectrum of an isotopic mixture of chlorodifluoromethane (CHF2Cl, Freon-22) with a 33% fraction of 13C and a natural ratio of chlorine isotopes was measured in the frequency range 1400-740 cm–1 with a resolution of 0.001 cm–1 at a temperature of 20C. An ab initio calculation of the structure and sextic potential energy surface and surfaces of the components of the dipole moment has been carried out by the the electronic quantum-mechanical method of Möller-Plesset, MP2/cc-pVTZ. Then the potential was optimized by replacing the harmonic frequencies with the frequencies calculated by the electronic method of coupled clusters, CCSD(T)/aug-cc-pVQZ. The fundamental and combination frequencies were calculated using the operator perturbation theory of Van Vleck (CVPTn) of the second and fourth order (n=2,4). Resonance effects were modeled using an additional variational calculation in the basis up to fourfold VCI excitation (4). The average prediction error for the fundamental frequencies of the 12C isotopologues was ~1.5 cm–1. The achieved accuracy made it possible to reliably predict the isotopic frequency shifts of the 13C isotopologues. It is shown that the strong Fermi resonance ν4/2ν6 dominates in the 12C isotopologues and is practically absent in 13C. The literature assumption [Spectrochim. Acta A, 44: 553] about the splitting of ν1 (CH) due to the resonance ν1/ν2+ν7+ν9 is confirmed. The coefficients of the polyadic quantum number are determined. The analysis made it possible to carry out a preliminary identification of the centers of the vibrational-rotational bands of isotopologues 13CHF235Cl и 13CHF237Cl in the spectrum of the mixture in preparation for individual analyzes of the vibrational-rotational structures of individual vibrational transitions.
25-21
Authors: Chukalina E. P.  , Igolkina T. A.  , Karimov D. N
Published: September 2022

We report on the high-resolution Fourier spectroscopy study of KY3F10:Pr3+ crystals. The analysis of the transmission and luminescence spectra allowed us to refine and supplement the information on the crystal-field levels of the Pr3+ ion. The value of the hyperfine splitting of the ground state of Pr3+ in the KY3F10 cubic matrix is estimated. The observed shape of the spectral lines indicates the presence of defects in the sample under study.
38-21
Authors: Krylosv A. S.  , Vtyurin A. N.  , Gudim I. A.  , Nemtsev I. V.  , Krylova S. N.
Published: September 2022

The Raman spectra of four crystals of TbFe3-хGax (BO3) 4 solid solutions (x from 0 to 0.54) were studied in the temperature range from 8 to 350 K. The temperatures of structural phase transitions were determined. The observed spectral behavior is characteristic to condensation and restoration of soft modes. Soft modes are associated with a structural phase transition from the R32 phase to the P3121 phase. The Compositions-Temperature phase diagram was constructed
42-21
Authors: Karimullin K. R.  , Arzhanov A. I.  , Surovtsev N. V.  , Naumov A. V.
Published: September 2022

The temperature-dependent luminescence spectra were analyzed to determine the parameters of the electron-phonon interaction (Huang-Rhys factor and the average phonon energy) for nanocomposites with colloidal CdSe/CdS/ZnS quantum dots (deposited on the surface of a glass substrate and embedded in a thin polymer film of polyisobutylene, and in a frozen colloidal solution in toluene). The measured values of the parameters are analyzed in comparison with model calculations and data obtained using the low-frequency Raman spectroscopy. It is found that in the case of a vitrified colloidal solution of quantum dots in toluene, the matrix effect leads to a noticeable change in the parameters of the electron-phonon interaction.
36-21
Authors: Smirnova E. A.  , Lozing N. A.  , Gladush M. G.  , Naumov A. V.
Published: September 2022

The current paper demonstrates theoretical analysis of two types of spectral curves for several configurations of system of two-level light emitters, considering the influence of local field and close environment inside a transparent medium. Probe field absorption spectra and resonant fluorescence spectra are calculated under excitation of a strong monochromatic cw laser. The sensitivity of absorption and emission optical spectroscopy method is compared for revealing the effects of the medium on individual emitters and their ensembles. Spectral curves were calculated for model emitters considering local field influence of a transparent dielectric medium and local electron-phonon interactions, which determined the response of the emitters to an external laser field and effective relaxation mechanisms. The calculation formalism is based on a semiclassical approach, while the relaxation processes associated with the phonon contribution are introduced phenomenologically with references to other studies.
35-21
Authors: Blois L.  , Carneiro Neto A. N.  , Longo R. L.  , Costa I. F.  , Paolini T. B.  , Brito H. F.  , Malta O. L.
Published: September 2022

Eu3+ complexes and specially β-diketonate compounds are well known and studied in several areas due to their luminescence properties, such as sensors and lightning devices. A unique feature of the Eu3+ ion is the experimental determination of the 4f-4f intensity parameters Ωλ directly from the emission spectrum. The equations for determining Ωλ from the emission spectra are different for the detection of emitted power compared to modern equipment that detects photons per second. It is shown that the differences between Ωλ determined by misusing the equations are sizable for Ω4 (ca. 15.5%) for several Eu3+β-diketonate complexes and leads to differences of ca. 5% in the intrinsic quantum yields Q_Ln^Ln. Due to the unique features of trivalent lanthanide ions, such as the shielding of 4f-electrons, which lead to small covalency and crystal field effects, a linear correlation was observed between Ωλ obtained using the emitted power and photon counting equations. We stress that care should be exercised with the type of detection should be taken and provide the correction factors for the intensity parameters. In addition, we suggest that the integrated intensity (proportional to the areas of the emission band) and the centroid (or barycenter) of the transition for obtaining Ωλ should be determined in the properly Jacobian-transformed spectrum in wavenumbers (or energy). Due to the small widths of the emission bands of typical 4f-4f transitions, the areas and centroids of the bands do not depend on the transformation within the experimental uncertainties. These assessments are relevant because they validate previously determined Ωλ without the proper spectral transformation.
Numerical modeling of carbides behavior under high-energy liading
Authors: K. K. Maevskii
Published: September 2022

The results of research on modeling thermodynamic parameters ofshock-wave loading of carbides with different stoichiometric ratios arepresented. The carbides are considered as a mixture of carbon with thecorresponding component. The calculations of pressure, compression andtemperature values under shock-wave loading for solid and porous carbides inthe range of pressure values above 3 GPa are performed. The modelcalculations are compared with the known experimental results on theshock-wave loading of carbides with different porosity values. Thepossibility of modeling the behavior according to the proposed method forcarbides for which there are no experimental data at high dynamic loads isshown. Keywords: Equation of state, shock adiabat, thermodynamic equality,porous heterogeneous medium, carbides\
Radar absorbing properties of polyvinyl alcohol/Ni-Znferrite-spinel composite
Authors: Kostishyn V.G.  , Isaev I.M.  , Shakirzyanov R.I.  , Salogub D. V.  , Kayumova A.R.  , Olitsky V.K.
Published: September 2022

The electromagnetic and radio-absorbing characteristics offerrite-polymer composites with conductive inclusions based on polyvinylalcohol are investigated. The Ni-Zn spinel ferrite powder of 2000NN gradewith composition Ni0.32Zn0.68Fe2O4 was used as filler. It is shown that theobtained composites are effective absorbers in the frequency range of 2-5 GHz with peak reflection loss less than ~20 dB. Through the analysis of thepermittivity spectra and permeability spectra, as well as the calculatedreflection loss spectra, critical factors of the electromagnetic waveabsorption in obtained composites are established. Keywords: polymer composite, radio absorption, nickel-zinc ferrite,polyvinyl alcohol\
Application of the method of dielectric spectroscopy to study theproperties of blood serum of mice with malignant ascites
Authors: Salnikova Zh. A.  , Smirnov A. P.  , Bogdanov A. A.  , Verlov N. A.  , Kastro R. A.
Published: September 2022

The article presents the results of a study by the method ofdielectric spectroscopy of high-frequency relaxation processes in the bloodserum of intact mice and mice vaccinated with an oncological disease --- Ehrlich's ascites carcinoma. Using the formalism of the electrical module,the relaxation parameters were calculated for the serum samples of the twostudied systems. Keywords: electrical module, relaxation parameters, oncological disease.\
A method to detect the characteristics of intermittent generalized synchronization based on calculation of probability of the synchronous regime observation
Authors: Moskalenko O. I.  , Koronovskii A. A.  , Selskii A. O.  , Evstifeev E. V.
Published: September 2022

A method to define the characteristic phases in the behavior of unidirectionally coupled systems located near the boundary of the generalized chaotic synchronization regime onset based on calculating the probability of the synchronous regime observation in an ensemble of coupled systems is proposed. Using the example of unidirectionally coupled Rossler systems in the band chaos regime, we have shown its efficiency in comparison with other known methods for detecting the characteristics of intermittent generalized synchronization. Keywords: generalized synchronization, intermittent behavior, unidirectionally coupled systems, multistability, laminar phases, probability of the laminar phase observation.
Determination of thickness and doping features of multilayer 4H-SiC structures by frequency analysis of IR reflection spectra
Authors: Afanasjev A. V.  , Zubkov V. I.  , Ilyin V. A.  , Luchinin V. V.  , Pavlova M. V.  , Panov M. F.  , Trushliakova V. V.  , Firsov D. D.
Published: September 2022

A technique has been developed for frequency analysis of the IR reflection spectrum to determine the thickness and order of the layers in the epitaxial structure of silicon carbide. Calculations for the 4H-SiC epitaxial structure have been performed. The method has been shown to be highly sensitive to optical boundaries resulting from a sequential increase in the doping level during the layer growth. Keywords: Silicon carbide, epitaxial layer, IR reflection, spectrum
A Conversation with the Organizers of Saving Ukrainian Cultural Heritage Online (SUCHO)
Authors: LeBlanc Zoe , Janco Andrew , Wermer-Colan Alex , Dombrowski Quinn , Kijas Anna , Majstorovic Sebastian , Strong Dena , Peaslee Erica
Published: September 2022

Following the Russian invasion of Ukraine this February, a global community of volunteers has endeavored to help preserve Ukraine’s online cultural heritage. While this community comprises over 1300 volunteers, many of them work as librarians or in cultural preservation, including two of the leaders of this group, Quinn Dombrowski and Anna Kijas. Dombrowski and Kijas, along with Sebastian Majstorovic, have been instrumental in coordinating this community of experts across time zones together and also spearheading what the Washington Post described as “a lifeline for cultural officials in Ukraine.” To capture both their experiences, as well as how librarianship has informed SUCHO, we convened a roundtable with the organizers, as well as two of the most active volunteers Dena Strong and Erica Peaslee, who also work in GLAM.
Analysis of the HBsAg status of toddlers born to HbsAg-reactive mothers at the Sikumana Community Health Center, Kupang City, in 2021
Authors: Hurek Rosina Kardina Kidi , Mindarsih Theresia , Pay Frida Sisternike
Published: September 2022

Background: Hepatitis is an infectious disease which is regarded as a public health problem due to its high prevalence. It is an inflammation of the liver that may develop into fibrosis, cirrhosis or liver cancer. The data obtained from the basic health research in 2017 shows that East Nusa Tenggara has the second highest percentage of HBsAg reactive-amongpregnant women in Indonesia (5.26%).

Objectives: This study aims to analyze the HBsAg status of toddlers born from pregnant women with HbsAg-reactive at the Sikumana Health Center, Kupang City, in 2021.

Methods: This is an analytical research carried out with a quantitative approach carried out and a cross sectional research design. This research was conducted at the Sikumana Community Health Center in September-October 2021 with a total sample of 53 toddlers born to HBsAg-reactive pregnant women in 2019. The data used were primary data collected using instruments in the form of questionnaires and blood samples taken for the HBsAg examination which was carried out by laboratory workers at the Sikumana Community Health Center. Meanwhile, the data analysis was performed using univariate and bivariate (chi square) method with version 20 of SPSS application.

Results: The results show that there were 53 HbsAg-reactive pregnant women at the Sikumana Community Health Center, Kupang City, and most of whom (83.0%) had good knowledge about Hepatitis B. The HBsAg RDT test in infants born to pregnant women with HbsAg-reactive revealed that there were 4 toddlers (7.5%) with HBsAg reactive, indicating that there was still a failure in immunoglobulin (HBIg). Furthermore, the results of the chi square test showed that there was a relationship between mother's knowledge, child's age, and history of HBIG administration with toddler's HBsAg status.

Conclusions: Health workers are expected to increase education and socialization about Hepatitis B and the importance of re-examination of infants who have received HBIG immunoprophylaxis. The re-examination is necessary considering that the confirmation examination program for the HBsAg RDT test has not been going well and immunoglobulin (HBIg) failures still occurred even if only in small number. Furthermore, this re-examination plays pivotal role to detect the effectiveness of HBIG so that early treatment can be given if there is a HBIG failure.
Psychoeducation in impproving psychological support for caregiver of chilhood cancer: literature review
Authors: Hasanah Laila Nidaul , Allenidekania Allenidekania
Published: September 2022

Background: Cancer is one of the main causes of death in the world, especially in developing countries. Cancer is not only a problem for adults but also a major health problem in children. Cancer in children is a chronic disease and responds to parents/caregivers. Psychological and emotional responses cause psychological problems and stress in parents/caregivers. One of the interventions to reduce psychological problems is psychoeducation. Family psychoeducation is a  modality of therapy with the focus of treatment on the family.

Objectives: To know various psycho-educational techniques and their impact on increasing caregiver psychological support

Methods: The research method used is a literature review using the Proquest, Pubmed, Google Scholar, and Science Direct databases, with the keywords caregiver or parent or family and pediatric cancer or childhood cancer and psychoeducation or psychosocial and psychological support.

Results: This study provides diversity in providing psychoeducation to caregivers with cancer children. Various techniques are used in the form of positive thinking, cognitive therapy, and brief therapy, educational and psychosocial techniques. The various techniques used have a positive impact on reducing anxiety, depression, stress, and trauma, improving coping strategies and quality of life, and increasing family resilience.
Conclusions: Psychoeducation is a nursing intervention that can be given to caregivers with childhood cancer. Psychoeducation is given to caregivers to improve the ability to care for patients and increase psychological support.
Robots in Assisted Living Facilities: Scoping Review (Preprint)
Authors: Trainum Katie , Tunis Rachel , Xie Bo , Hauser Elliott
Published: September 2022

BACKGROUND

Various technological interventions have been proposed and studied to address the growing demand for care of residents in assisted living facilities, in which a preexisting shortage of professional caregivers has been exacerbated by the COVID-19 pandemic. Care robots are one such intervention with the potential to improve both the care of older adults and the work life of their professional caregivers. However, concerns about efficacy, ethics, and best practices in the applications of robotic technologies in care settings remain.

OBJECTIVE

This scoping review aimed to examine the literature on robots used in assisted living facilities and identify gaps in the literature to guide future research.

METHODS

On February 12, 2022, following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) protocol, we searched PubMed, CINAHL Plus with Full Text, PsycINFO, IEEE Xplore digital library, and ACM Digital Library using predetermined search terms. Publications were included if they were written in English and focused on the use of robotics in assisted living facilities. Publications were excluded if they did not provide peer-reviewed empirical data, focused on user needs, or developed an instrument to study human-robot interaction. The study findings were then summarized, coded, and analyzed using the Patterns, Advances, Gaps, Evidence for practice, and Research recommendations framework.

RESULTS

The final sample included 73 publications from 69 unique studies on the use of robots in assisted living facilities. The findings of studies on older adults were mixed, with some studies suggesting positive impacts of robots, some expressing concerns about robots and barriers to their use, and others being inconclusive. Although many therapeutic benefits of care robots have been identified, methodological limitations have weakened the internal and external validity of the findings of these studies. Few studies (18/69, 26%) considered the context of care: most studies (48/69, 70%) collected data only on recipients of care, 15 studies collected data on staff, and 3 studies collected data on relatives or visitors. Theory-driven, longitudinal, and large sample size study designs were rare. Across the authors’ disciplines, a lack of consistency in methodological quality and reporting makes it difficult to synthesize and assess research on care robotics.

CONCLUSIONS

The findings of this study call for more systematic research on the feasibility and efficacy of robots in assisted living facilities. In particular, there is a dearth of research on how robots may change geriatric care and the work environment within assisted living facilities. To maximize the benefits and minimize the consequences for older adults and caregivers, future research will require interdisciplinary collaboration among health sciences, computer science, and engineering as well as agreement on methodological standards.
Changes in Intrapersonal Factors of Participants in the Pregnancy Remote Monitoring Study Who Are at Risk for Pregnancy-Induced Hypertension: Descriptive Quantitative Study (Preprint)
Authors: Lanssens Dorien , Vandenberk Thijs , Storms Valerie , Thijs Inge , Grieten Lars , Bamelis Lotte , Gyselaers Wilfried , Tang Eileen , Luyten Patrick
Published: September 2022

BACKGROUND

The peripartum period, defined as the period from the beginning of the gestation until 1 year after the delivery, has long been shown to be potentially associated with increased levels of stress and anxiety with regard to one’s transition to the status of parent and the accompanying parental tasks. Yet, no research to date has investigated changes in intrapersonal factors during the peripartum period in women at risk for pregnancy-induced hypertension (PIH).

OBJECTIVE

The aim of this study is to explore and describe changes in intrapersonal factors in participants at risk for PIH.

METHODS

We used an explorative design in which 3 questionnaires were sent by email to 110 participants the day following enrollment in the Pregnancy Remote Monitoring program for pregnant women at risk for PIH. Women were invited to complete the questionnaires at the beginning of their participation in the Pregnancy Remote Monitoring project (mostly at 14 weeks of gestation) and after approaching 32 weeks of gestational age (GA). The Generalized Anxiety Disorder-7 Scale (GAD-7) and the Patient Health Questionnaire-9 were used to assess anxiety and depression, and adaptation of the Pain Catastrophizing Scale was used to measure trait pain catastrophizing.

RESULTS

Scores were significantly higher at 32 weeks of GA than at the moment of enrollment (GAD-7 score=7, range 4-11 vs 5, range 3-8; P=.01; and Patient Health Questionnaire-9 score=6, range 4-10 vs 4, range 2-7; P<.001). The subscale scores of the Pain Catastrophizing Scale were all lower at 32 weeks of GA compared with 14 weeks of GA (rumination: 4, range 1-6 vs 5, range 2-9.5; P=.11; magnification: 3, range 1-5.5 vs 4, range 3-7; P=.04; and helplessness: 5, range 2-9 vs 6, range 3.5-12; P=.06). The proportion of women with a risk for depression (GAD-7 score >10) was 13.3% (10/75) at enrollment and had increased to 35.6% (26/75) at 32 weeks of GA.

CONCLUSIONS

This study shows that pregnant women at risk for PIH have higher levels of stress and anxiety at 32 weeks of GA than at the moment of enrollment. Further research is recommended to investigate potential strategies to help pregnant women at risk for PIH manage feelings of stress and anxiety.

CLINICALTRIAL

ClinicalTrials.gov NCT03246737; https://clinicaltrials.gov/study/NCT03246737
Factors associated with food choice motives of adolescents in Yogyakarta Special District
Authors: Wahyuningtyas Rifka , Wisnusanti Setyo Utami , Kusuma Mutiara Tirta Prabandari Lintang
Published: September 2022

Background: Adolescents begin to have eating autonomy which causes changes in behavior and habits related to food selection. Various factors are considered to be able to influence food choice motives. Objective: The study aimed to determine factors related to adolescents' food choice motives. Methods: A cross-sectional study involving 121 students who studied at two state Junior High schools in Yogyakarta Special District (YSD) from April to May 2020. The independent variables are gender, perception of body image, nutritional knowledge, peer influence, school location, amount of pocket money, family income, parental education, and media influence. The dependent variables are nine food choice motives. Data collection was used online questionnaires via an online form. The data were analyzed by using multiple linear regression. Results: Most respondents had health motive as their primary motive in food choice, followed by natural content, price, and ethical concern. This research also found that there was a relationship between nutritional knowledge with a natural content motive; media influence, nutritional knowledge, and amount of pocket money with ethical concern motive; parental education with price motive; perception of body image, media influence, amount of pocket money, and nutritional knowledge with weight control motive (p<0,05). Conclusions: Perception of body image, nutritional knowledge, media influence, amount of pocket money, and parental education were related to the food choice motives of adolescents. Future intervention strategies related to healthy eating behavior in adolescents can be designed based on these factors.* Presented at the International Nutrition and Health Symposium (INHESION) on Sunday, November 15th, 2020, in Yogyakarta, organized by HIMAGIKA and the Department of Health Nutrition, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
Pengaruh chronotype dan tingkat stres terhadap status gizi dengan mediator perilaku makan pada mahasiswa perkuliahan daring
Authors: Rafkhani Tesa , Fanani Mohammad , Nuhriawangsa Adi Magna Patriadi
Published: September 2022

The effect of chronotype and stress levels on nutritional status mediated by eating behavior in college students with online lectureBackground: College students are a group at risk of experiencing changes in stress levels, changes in eating behavior, and sleep quality. Unhealthy eating behavior, if done continuously, will lead to weight gain.Objective: This study aims to analyze the effect of chronotype and stress levels on nutritional status mediated by the eating behavior of college students with online lectures.Methods: Cross-sectional survey with multistage cluster random sampling on 220 respondents. Chronotype data used by Morningness - Eveningness Questionnaire (MEQ). Stress level data using by Perceived Stress Scale (PSS-10) questionnaire. Eating behavior data was used by Dutch Eating Behavior Questionnaire (DEBQ). Nutritional status data is measured according to body mass index (BMI) by measuring weight (kg) and height (m2). Data were analyzed using Partial Least Square-Structural Equation Model (PLS-SEM) analysis using SmartPLS software.Results: The results showed that there was a significant indirect effect between chronotype (x1) on nutritional status (y2) mediated by eating behavior (p=0.037) with an impact of 0.085 or 8.5%. In comparison, the magnitude of the direct effect without a mediator was 0.193 or 19.3%. Furthermore, there is a significant indirect effect between stress level (x2) on nutritional status (y2) mediated by eating behavior (p=0.017) with an impact of 0.074 or 7.4%. The direct effect without a mediator is 0.217 or 21.7%.Conclusions: There is a significant indirect effect between chronotype and stress level on nutritional status mediated by eating behavior in students with online lectures. During the COVID-19 pandemic, college students should continue to pay attention to healthy eating behavior by preventing emotional eating, setting bedtime earlier, and avoiding stress by increasing physical activity.
Problem and Alternative Solutions: Impact of Changes in Law concerning Regional Government on the Law of the National Sea
Authors: Khomsin Khomsin
Published: September 2022

As one of the largest archipelagic countries in the world, Indonesia has an area of inland waters of 3.11 million km2 and a territorial sea area of 290,000 km2. Indonesia also has 17,504 islands, 34 provinces, and 514 cities/districts. For orderly administration, the government and parliament established Law No. 32/2004 amended by Law No. 23/2014 concerning regional governance. In both laws, there is little regulation on the management of marine areas in the provinces and districts/cities. Since the Law No. 32 of 2004 on amendments became Law No. 23 of 2014, some problems arose, namely vertical references, management authority, and archipelagic provinces or districts/cities. This paper describes the problems and alternative solutions to address the problems caused by the amendments to Law no. 32/2004 into Law no. 23/2014. The method used is to compare the vertical references used by Law no. 32/2004 namely LWL with Law. No. 23/2014 namely HWL. The results of this study recommend that to return to the vertical reference used, it must return to HWL by UNCLOS 1982. In addition, the authority for managing marine areas must also be returned to the district and city governments and there is recognition of districts/cities and archipelagic provinces that are not separated by the sea.
Migration Trajectories among Rural Households in Indonesia
Authors: Pitoyo Agus Joko , Ihwanudin Idris , Sukamdi Sukamdi , Alfana Muhammad Arif Fahrudin , Aryati Seri
Published: September 2022

International migration trajectory is one of the important aspects discussed when viewing the migration culture of a region. The specific types and patterns created are unique and dependent on the length of the migration history. Therefore, this study is aimed to explain the migration history carried out by residents in Ponorogo Regency, East Java Province, and the factors that influence international migration. This is a survey research of 515 international migrants. The results showed that the migration pattern in Ponorogo Regency was divided into one, two, and three destination countries with temporal space-related cultural factors used to determine an important influence on rural households' ability to work abroad. Similar to other studies, age and gender are the two key variables related to migration trajectories in Ponorogo Regency.
Rapid spatial growth of cities and its planning implications for developing countries: a case study of Abuja, Nigeria.
Authors: Chukwurah Gladys Ogochukwu , John-nsa Chioma Onwuneme , Okeke Francis , Chukwudi Eze Charles , Ogorchukwu Isimah Matthew
Published: September 2022

Accelerated spatial growth of urban areas is a key driver to land use/land cover change with its concomitant effect on environmental sustainability. The dearth of data on the rate of urban expansion, especially in many developing countries, including Nigeria has continued to hinder effective land use planning and sustainable development. The study aims to identify and analyze the settlement patterns and trends in urban growth at ten years intervals and their planning implications in Abuja, Nigeria. It relied on data generated via remote sensing and Geographic Information Systems to create the map and examine the land cover change in the study area. Classification of land cover using LANDSAT data and land cover transitions for 29 years (1990 to 2019) were mapped and the net land cover change was computed. The results showed the settlement pattern and an increase in the urban built-up area ranging from 1.8% in 1990 to 19.3% in 2019. The dispersion pattern revealed a large concentration of the built-up spaces to be in the eastern region and that the expansion continued from east to south and south-west. The bare land cover types were found to have increased while vegetation land cover decreased rapidly by 30.4% from 1990-2019. The study recommends the need for city planners to decentralize urban planning and development control with adequate provision of affordable urban facilities at the peripheries of cities in Nigeria. Furthermore, massive integration of green infrastructure in built-up areas is required to mitigate the effects of vegetation loss in cities.
Peran Socio-Personal Petani Dalam Kaitannya Dengan Keputusan Menentukan Jenis Komoditi Pertanian di Desa Duren Kecamatan Bandungan
Authors: Sudrajat Sudrajat , Agista Devi Ega , Rohmah Siti
Published: September 2022

Abstrak: Keputusan  menentukan jenis komoditi pertanian yang akan diusahakan pada lahan pertanina  tidak terlepas dari pengaruh kondisi sosiol-demografi maupun budaya petani. Berdasarkan hal tersebut penelitian ini dilakukan dengan tujuan untuk menganalisis peran  socio-personal petani kaitannya dengan keputusan menentukan jenis komoditi pertanian. Metode survei digunakan untuk mengambil  sampel di lapangan. Pengukuran data kualitatif menggunakan metode skala likert dan dianalisis dengan menggunakan metode quartil (Q), sedangkan analisis data  kuantitatif menggunakan uji statistik logistik binari. Hasil analisis menemukan bahwa aspek socio-personal petani yang diwujudkan dalam aspek socio-culture  sangat berperan terhadap keputusan petani menentukan jenis komoditi pertanian. Hasil uji regresi logistik binari  menunjukkan bahwa peran aspek socio-cultutre petani berpengaruhi signifikan terhadap keputusan petani menentukan jenis komoditi padi daripada jenis komodti lainnya. Demikian, juga dengan faktor umur dan pengalaman petani berpengaruh siginifikat terhadap keputusan petani menentukan jenis komoditi padi, sedangkan faktor pendidikan tidak signifikan. Abstract: The decision to determine the type of agricultural commodity to be cultivated on agricultural land cannot be separated from the influence of socio-demographic conditions and farmers' culture. Based on this, this research was conducted with the aim of analyzing the socio-personal role of farmers in relation to the decision to determine the type of agricultural commodity. The survey method was used to take samples in the field. Qualitative data measurement using the Likert scale method  and analyzed using the quartile (Q) method.  while the quantitative data analysis used binary logistic statistical tests. The results of the analysis found that the socio-personal aspects of farmers which were manifested in the socio-cultural aspects played a very important role in the farmers' decisions to determine the types of agricultural commodities. The results of the binary logistic regression test show that the role of the socio-cultural aspect of farmers has a significant effect on the decision of farmers to determine the type of rice commodity rather than other types of commodities. Likewise, the age and experience of farmers have a significant effect on farmers' decisions to determine the type of rice commodity, while the education factor is not significant.
The Multiverse: A Unique Movement towards Absolute Truth
Authors: Fang Zihan
Published: September 2022

There is a distinct relationship between the multiverse theory and the perception of truth when viewed through the lens of German Idealism. At their core, both theories are concerned with movement, or a constant state of flux. This paper draws two analogies between the multiverse theory and German Idealism. First, Kant’s theory of “the thing-in-itself” is posited as a rejection of the idea of a unified universe. Second, similarities are drawn between how the multiverse can be seen as layers of shifting reality and Hegel’s description of the road towards truth, which is filled with movements toward negation and advancement. Finally, the paper discusses how these analogies constitute a critique of scientism: the multiverse theory, as well as German Idealism’s concept of truth, both stand in direct contrast to how modernity places dogmatic and exaggerated trust in empirical science.
EVALUATION OF RELEASED TEF (ERAGROSTIS TEF [ZUCC.] TROTTER) VARIETIES AT SOUTHWESTERN PART OF ETHIOPIA
Authors: BELETE TEGEGN
Published: September 2022

Objective: The objective of the study was to evaluate performance and identify high yielding and stable variety for southwestern part Ethiopia and recommend identified varieties for large scale production.
Experimental Materials: Eight nationally released tef varieties were included in the study. The materials were obtained from Debre Zeit Agricultural Research Center (DZARC).
Design and Trial Management: The experiment was conducted during the 2019 main cropping season at six locations, namely: Melko, Gechi, Omonada, Kersa, Mana, and Gooma weredas of Southwestern Ethiopia. The trial was conducted using randomized complete block design with three replications at all locations under rain-fed conditions. Sowing was done manually. Spacing between plots was 1 m, whereas that between replications was 1.5 m and the total plot size was 2 m × 2 m. Seed rates were based on the recommendation which was 15 kg/ha.
Result and Discussion: Analysis of variance revealed the presence of significant (P < 0.05) differences among eight tef varieties of traits of days to heading, days to maturity, plant height, panicle length, lodging index, above ground biomass, and grain yield across locations. This indicated the presence of performance variation among the tested varieties for grain yield and it is possible to identify high yielder varieties for possible use in these locations.
Conclusion and Recommendation: In general, varieties Dagim and Kora were high yielding and stable across locations and variety Gibe, Tesfa, and Negus were stable and low yielders across locations. The high yielding and stable varieties were recommendable for large scale production in southwestern part of Ethiopia. The experiment used data collected for only one season, which may limit the strength of its recommendation. However, the results are crucial in directing the breeding decision following additional season evaluation of the varieties in the same locations.
IN SILICO ANALYSIS OF PHYTOCHEMICALS FROM ZINGIBER OFFICINALE FOR THE INHIBITION OF TUMOR PROTEIN-53 BINDING PROTEIN 1 ASSOCIATED WITH HEPATOCELLULAR CARCINOMA
Authors: M PRIYANKA , A SNEHA , KHAN NILOFAR
Published: September 2022

Objectives: The bioactive phytocompounds present in Zingiber officinale were assessed for their tumor-suppressing activity against TP-53 BP1 linked to hepatocellular carcinoma.
Methods: The study investigates the interaction of the phytochemicals from Ginger (Zingiber officinale) with the tumor protein TP53. Drug likeness of the chosen ligand was evaluated using SWISS ADME. The Autodock tools were used to investigate the interactions of the ligands with that TP-53 BP1 protein. The docking interactions were visualized using PLIP (Protein-Ligand Interaction Profiler).
Results: It is observed that all the ligands show high gastrointestinal absorption along with the presence of blood-brain barrier permeability and have moderate solubility whereas Gingerenone A exhibits high solubility up to par. Docking analysis shows high-efficiency binding of the ligand (Gingerol) to the receptor.
Conclusion: The bioactive ligand gingerol is a beta-hydroxy ketone compound that displays better binding with the tumor proteins.
COMPUTATIONAL PREDICTION OF BIOACTIVE COMPOUNDS AS POTENTIAL INHIBITORS OF COVID-19 MAIN PROTEASE, SPIKE GLYCOPROTEIN RECEPTOR-BINDING DOMAIN, AND RNA-DEPENDENT RNA POLYMERASE
Authors: SHARMA RUCHIKA , BUWA VAEESHNAVI
Published: September 2022

Objectives: It has been known for ages that natural products have potent antiviral activity and hence show inhibitory effects on SARS-CoV-2 infections. In this study, some promising bioactive compounds from natural sources for drug development against SARS-CoV-2 were studied.
Methods: The study was based on a computational approach using different phytochemicals for evaluating their potential against non-structural (main protease [MPro], RNA-dependent RNA polymerase [RdRp], and structural [spike [S] glycoprotein receptor-binding domain]) viral proteins. Molecular docking was conducted systematically using PyRx and AutoDock 4.2 to determine the binding affinities between bioactive compounds and Mpro, spike RBD, and RdRp. Twenty-two ligands were selected in this study from different sources including three known inhibitors of the virus remdesivir, favipiravir, and nelfinavir. The pharmacological assessment of the ligands was achieved using ADMET filters.
Results: The docking results revealed that β-carotene, piperine, and cianidanol were the best antagonists for Mpro, isovitexin, quercitin, β-carotene, piperine, and cianidanol were the best antagonists for RdRp, and in case of the spike RBD, capsaicin, cianidanol, curcumin, gingerol, isovitexin, piperine, quercitin, rhapontin, and riboflavin were found to be best.
Conclusion: All of these bioactive compounds could be considered potential drug candidates for COVID-19 inhibition due to their promising binding affinities with the viral structural and non-structural proteins.
HUMAN RIGHTS AS TAUGHT BY THE QUR’AN, SUNNAH OF THE PROPHET (SAW), AND HIS RIGHTLY GUIDED CALIPHS
Authors: AHMED NURA , SALISU AUWAL , YAKASAI MUSA UMAR
Published: September 2022

The paper examines the human rights taught by the prophet Sallallahu Alaihi wa Sallam (SAW) and his rightly guided caliphs. The rights in Islam are all provided by Allah, the lawgiver, that is to say, a divine revelation (Qur’an) regulates and specifies the human rights and the explanation of His prophet (SAW), otherwise called Sunnah. Therefore, Qur’an and Sunnah are vital sources of information on human rights in Islam. Similarly, the paper investigates the theoretical concepts, the origin of the human species; it also considers the difference between human beings and other creatures. Before Islam, the period was also cognizance of how human beings’ rights were respected in our contemporary era. Therefore, the relevance of rights from an Islamic point of view and western understanding is known as (Man-made Law), which only considers the rights of individuals and means the struggle. Therefore, the Islamic religion aims to have a peaceful society that provides these rights classes to people, thereby granting them religious, social, and moral satisfaction.