bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposta de plano de ação, no âmbito do programa saúde na escola, para prevenção e controle da obesidade infantil em um município da grande São Paulo - SP
Authors: Da Silva Alves Batista Mariangela
Published: May 2021

O presente trabalho teve por objetivo elaborar um plano de ação para prevenção e controle da obesidade infantil, no âmbito do Programa Saúde na Escola (PSE), para escolas municipais de ensino fundamental de um Município da Grande São Paulo – SP. Métodos: foram realizados 3 (três) encontros com gestores e profissionais das áreas da saúde e da educação para construção do plano de ação de acordo com a realidade local. Resultados: foram escolhidas 3 Unidades de Saúde da Família (1 na região central e 2 em regiões periféricas) e 5 escolas (1709 alunos) prioritárias para a proposta de repactuação do PSE. Optou-se pela potencialização das ações já realizadas por estas escolas, como, por exemplo, a Horta Escolar. Foi proposta a construção de um grupo de trabalho intersetorial para planejamento e gestão das ações. Conclusão: as discussões e reuniões com profissionais e gestores da área da saúde e educação possibilitaram a construção de um plano de ação adequado à realidade local e especificidades das escolas e unidades básicas de saúde.
O uso de informações para o processo de territorialização no planejamento da Atenção Básica
Authors: Vitorino Marcos Ricardo , Câmara Gampietro Julia Fernanda , Schiavon Duarte Ligia , da Costa Rosa Tereza Etsuko
Published: May 2021

A doença renal crônica (DRC) tem ganhado destaque e preocupação pelo seu custo, pelo número de mortes e pelo impacto negativo na qualidade de vida das pessoas acometidas pelo agravo. Esse artigo apresenta reflexões com base em duas experiências desenvolvidas em âmbito municipal sobre a viabilidade da efetivação do processo de territorialização na Atenção Básica como enfrentamento dos problemas de saúde da população, em especial, do cuidado das doenças crônicas não transmissíveis. O uso de informações georreferenciadas na rotina de trabalho dos formuladores de políticas públicas, gestores da política e trabalhadores do SUS encontra obstáculos relacionados com o esforço necessário para a padronização das informações de bases de dados e para a capacitação dos trabalhadores para o uso de informações em planilhas eletrônicas. No entanto, cabe o esforço para ultrapassar esses entraves, posto que a utilização do georrefenciamento permite a sobreposição de camadas diversificadas de informações, o que possibilita identificar regiões intramunicipais de sobre risco para agravos como a doença renal crônica e compreender de forma mais geral as condições de vida da população. O fornecimento de um diagnóstico mais preciso sobre a distribuição das doenças no território municipal pode subsidiar discussões com a equipe e elaborar ações mais focalizadas.
O programa de tratamento do tabagismo oferecido pelo Sistema Único de Saúde no Estado de São Paulo
Authors: Longanezi Valeria , Goi Porto Alves Maria Cecília
Published: May 2021

O artigo apresenta análise do tratamento do tabagismo oferecido pelo SUS no estado de São Paulo, entre 2012 e 2105, e discute algumas das estratégias adotadas pelo Programa de Tratamento do Tabagismo. Foram verificados altos índices de cessação quando considerada a quarta sessão de tratamento (média 44,03%). A cobertura de serviços para promover o tratamento da população fumante mostrou-se baixa (menos de 10% em 2015), frente ao contingente de pessoas que desejam cessar o hábito de fumar. Aumentá-la é um desafio a ser enfrentado pelo Ministério da Saúde, coordenação estadual e municípios, que devem buscar estratégias que aumentem a oferta de atendimento e a divulgação dos serviços já existentes, no sentido de facilitar o acesso ao tratamento e a ação do tabagista em direção à cessação do hábito de fumar. Discussões realizadas com base nos resultados do estudo e sua utilização em cursos de capacitação para o tratamento do fumante têm contribuído para a sensibilização dos profissionais de saúde quanto à importância do cuidado ao tabagista e da redução da prevalência de fumantes.
Grupos de reflexão em saúde mental
Authors: Yamaguti Claudiney Augusto , De Lima Salum e Morais Maria
Published: May 2021

O presente trabalho tem como objetivo relatar a pesquisa-intervenção conduzida com uma equipe de Saúde da Família no que se refere às ações de Saúde Mental na Atenção Básica. A pesquisa foi desenvolvida no Município de Itapevi – SP. Para tal, foram realizados cinco grupos de reflexão com a equipe. Verificou-se nas discussões: pouca capacidade de identificação das demandas e riscos em saúde mental; tendência à medicalização do sofrimento mental; sentimento de impotência dos trabalhadores; inexpressiva participação dos usuários nos próprios tratamentos; discussões centradas nos casos graves; fragmentação do cuidado; práticas de promoção de saúde pouco consolidadas; diretrizes genéricas e falta de detalhamento dos fluxos de atenção e do tipo de abordagem terapêutica a ser utilizada em cada situação. Apesar dos problemas relatados, o trabalho possibilitou avanços na discussão da temática proposta, mudanças de percepção dos trabalhadores em relação à pessoa com sofrimento mental e a mobilização dos recursos internos dos trabalhadores para lidar com situações relacionadas com a saúde mental dos usuários. O trabalho foi apresentado para gestores do município, denotando sua potencialidade como elemento de introdução para o matriciamento em Saúde Mental, cuja implantação está em discussão no município.
Między Tekstem a Kulturą: Z Zagadnień Przekładoznawstwa
Authors: Grucza Franciszek , Krzeszowski Tomasz P. , Chruszczewski Piotr P. , Charzyńska-Wójcik Magdalena , Tabakowska Elżbieta , Majewski Marcin , Sporniak Artur , Szostek Teresa , Czajkowski Michał , Klimkowski Konrad , Piotrowska Maria , Knapik Aleksandra R. , Bogucki Łukasz , Deckert Mikołaj , Chojnowski Ryszard , Brzózka Aleksander , Dybiec-Gajer Joanna , Misior-Mroczkowska Aleksandra , Górski Tomasz P. , Zazula Piotr , Zielińska-Elliott Anna , Soliński Wojciech , Cimała Alicja
Published: May 2021

Przedmiotem badania tej monografii jest przekład. Przekład bywa tu pojmowany bardzo wąsko – jako produkt, szeroko – jako proces, a niekiedy wręcz bardzo szeroko – jako akt interpretacyjny, graniczący niemal z aktem stwórczym. Monografia zbudowana jest z prac wielu autorów (teoretyków przekładu, praktyków przekładu, językoznawców, literaturoznawców, kulturoznawców, germanistów, polonistów, italianistów, bohemistów, japonistów, hebraistów, latynistów, anglistów, a nawet teologa), zajmujących się różnymi aspektami przekładu. Autorzy tego tomu prezentują różne stanowiska, mieszczące się na skali między Nabokovem a Gadamerem. Część Autorów to badacze już obsypani nagrodami, inni dopiero wchodzą w świat badań i na nich nagrody dopiero czekają. Część zamieszczonych tu prac pięknie ze sobą współgra, a część pokazuje zgoła odmienne punkty widzenia na zgłębiany przedmiot badań. Jesteśmy zdania, że tak właśnie powinno być, jeśli tom ma rzetelnie reprezentować pewien wycinek uprawianej nauki, bowiem nauka opiera się na ścieraniu się poglądów. Pragnęliśmy, aby ta monografia była publikacją prawdziwą, która oddaje piórem swoich autorów faktyczny stan badań nad przekładem i przekładoznawstwem.
Przetłumacz mi książeczkę. Kilka słów o przekładzie literatury dziecięcej i młodzieżowej tylko dla dorosłych
Authors: Brzózka Aleksander
Published: May 2021

The following article focuses on ideology and power relations involved in the act of translating children’s literature. It is proposed that discussions within the theory of CLTS be shifted away from questions of how to produce better translations by avoiding manipulation to focusing on how manipulation and ideology work in translated texts for children. A series of fourteen Polish translations of Mark Twain’s Adventures of Tom Sawyer is used to show the influence that the translator’s ideosomatic and idiosomatic programming has on handling offensive and religious expressions. The extensive data collected allows for a detailed synchronic and diachronic analysis, which proves that although vocabulary considered inappropriate varies relative to both ideological and individual aspects, not a single translation avoids some degree of manipulation; reflecting both contemporary ideology and personal attitude.
Problemy tłumaczeniowe w przekładzie prozy Harukiego Murakamiego
Authors: Zielińska-Elliott Anna
Published: May 2021

Haruki Murakami’s texts stand out when it comes to their linguistic aspects. Despite writing in Japanese, Haruki Murakami often uses English loanwords, quotes, and intertextual references. By using such stylistic devices, the author gives rise to the feeling of estrangement. This is, however, often lost when his literature is translated into other languages. To set some of the characters apart, to show that they are different, lonely or eccentric, Murakami makes them speak in dialects. The most popular methods of translating such utterances include creating a fictitious dialect, using colloquial language or a parallel dialect existing in the target language, or omitting the dialect completely, therefore neutralizing how a given character speaks. In “Yesterday,” one of Murakami’s works translated by Anna Zielińska-Elliott into Polish, a character originally speaking the Kansai dialect uses the Poznań dialect.
EVALUASI PURNA HUNI PASAR TRADISIONAL KOTA PONTIANAK DITINJAU DARI ASPEK PERILAKU (STUDI KASUS: PASAR KEMUNING DAN PASAR DAHLIA)
Authors: M. Nurhamsyah  , M. Ridha Alhamdhani  , Rudiyono
Published: May 2021

Penataan pasar tradisional merupakan program kerja yang telah dijalankan Pemerintah Kota Pontianak. Kebijakan tersebut sebagai upaya untuk mempertahankan eksistensi pasar tradisional sebagai salah satu penggerak ekonomi bagi masyarakat berpenghasilan menengah dan menengah kebawah. Program penataan pasar tradisional yang telah diwujudkan antara lain penataan Pasar Kemuning dan Pasar Dahlia yang merupakan objek terpilih dalam penelitian ini. Sejalan berfungsinya pasar tersebut masih terdapat beberapa kendala, antara lain tidak semua kios/lapak yang digunakan dapat berfungsi, perubahan kapasitas pengguna lapak, dan perubahan posisi ruang lapak dari perencanaan awal. Penelitian ini bertujuan untuk mengevaluasi bangunan dengan melihat lingkup permasalahan perilaku pengguna pasar. Metode yang digunakan adalah Evaluasi Purna Huni (EPH) dari aspek perilaku yang mencakup faktor manusia sebagai pengguna bangunan, akses sirkulasi, titik simpul pergerakan, area teritori dan orientasi. Penelitian ini menggunakan 2 (dua) unsur data yaitu data literatur (standar), dan data observasi lapangan (data kuantitatif). Data literatur digunakan untuk melihat kesesuaian desain bangunan dengan standar yang telah ditetapkan. Data observasi lapangan adalah data primer berupa hasil pengamatan perilaku pengguna pasar dengan metode person center mapping. Kedua data tersebut kemudian dianalisis untuk melihat kondisi performa bangunan berdasarkan standar yang ada dan aspek perilaku pengguna pasar sehingga dapat menggambarkan tingkat kualitas performansi dan fungsi bangunan pasar. Hasil penelitian menunjukkan terdapat beberapa kesamaan kualitas perfomansi bangunan dari aspek perilaku antara kedua pasar terutama pada akses sirkulasi, titik simpul, teritori dan orientasi, meskipun diantara keduanya terdapat perbedaan dan ciri khas tertentu berdasarkan lokasi.
STUDI ANALISIS DIMENSI DAN STABILITAS TUBUH BENDUNGAN URUGAN BERINGIN SILA
Authors: Natalia Yuliana Margaretha  , I Made Kamiana  , Dwi Anung Nindito
Published: May 2021

Bendungan urugan Beringin Sila merupakan konstruksi penampung air yang direncanakan untuk mengatasi masalah ketidakseimbangan kuantitas air yang tersedia dalam memenuhi kebutuhan masyarakat di Kecamatan Utan, Kabupaten Sumbawa. Oleh karena itu, analisis dimensi dan stabilitas bendungan perlu dilakukan dengan tujuan memperoleh konstruksi bendungan yang efektif untuk menampung air dan memenuhi syarat keamanan bendungan yang dipengaruhi oleh gaya-gaya yang bekerja pada bendungan. Metode perhitungan yang digunakan dalam menentukan analisis dimensi yaitu penelusuran banjir kala ulang 1.000 tahun dan metode S.M.B. Metode perhitungan stabilitas yang digunakan yaitu metode Cassagrande untuk mengetahui formasi garis depresi dengan syarat Qf < Qinflowmaks, Forchheimer untuk menggambar jaringan trayektori, dan Bishop untuk mengetahui stabilitas lereng tubuh bendungan dengan syarat Fk > 1,2. Hasil perhitungan dimensi diperoleh tinggi bendungan 87 meter, lebar mercu 13 meter, panjang bendungan 800,93 meter, kemiringan lereng hulu 1:4, kemiringan lereng hilir 1:3, dimensi drainase horisontal 2 meter x 240 meter. Hasil analisis terhadap stabilitas aliran filtrasi bendungan diperoleh 11,88 x 10-3 m3/det < 11,88 m3/det (aman). Hasil analisis terhadap stabilitas lereng bendungan pada kondisi baru selesai dibangun sisi hulu 4,34 (aman) dan hilir 2,99 (aman), pada kondisi muka air bendungan mencapai elevasi penuh 2,13 (aman), dan pada kondisi bendungan mengalami penurunan air mendadak 3,82 (aman). Hasil analisis stabilitas terhadap boiling dan piping diperoleh 6,44 x 10-6 m/det < 0,06 m/det (aman).
AN EB IV DAGGER FROM TELL ES-SULTAN/JERICHO
Authors: Montanari Daria
Published: May 2021

The paper is focused on dagger TS.14.143, a weapon found in the Jericho Necropolis in an EB IV shaft tomb unfortunately violated by illegal diggers in the area of Cemetery A recovered by archaeologists. Such an item allows a series of observation on this renowned class of weapons, widely spread over Southern Levant during the Early Bronze Age IV
Influence of off-road vehicle trails on small mammal community structure in western Maryland
Authors: Thady Erin , Harlon Emily K. , Edwards Sabrina , Lambert Thomas D.
Published: May 2021

To minimize risks associated with off-road vehicle use, agencies often designate areas for off-road vehicle recreation; however, this can concentrate impacts. Trails can cause a change in habitat structure and may divide home ranges. Our objective was to survey small mammal populations along a newly established trail to determine whether small mammals were more impacted by changes to habitat structure or the creation of a barrier. Transects established along the trail were trapped to quantify small mammal community structure. Nine species were captured, with Peromyscus spp. being the most abundant. Peromyscus spp. abundance was significantly greater at the immediate trail edge than in the forest interior. Edge effects on habitat structure extended 50 m into the interior but did not appear to affect abundances significantly. Our study suggests that the trail edge itself is more important than the associated habitat change in driving changes to small mammal abundance.
Salamander survey of Jakey Hollow Natural Area, Columbia County, Pennsylvania
Authors: Hartzell Sean M.
Published: May 2021

With current declines in amphibian and reptile populations, herpetological surveys of protected natural areas are crucial to management of these organisms, especially as natural areas become more insular due to surrounding land use. Jakey Hollow Natural Area (JHNA) is a locally significant biological site in Columbia County, PA, consisting of wooded slopes bisected by a small-order stream. This report presents the results of a salamander survey at JHNA during the spring of 2020. Cover object surveys revealed a total of 190 salamanders belonging to seven species. The most common salamanders observed at JHNA were Plethodon cinereus and Desmognathus ochrophaeus, which typify other surveys of similar habitats in Pennsylvania. Other species found in lower abundance were D. fuscus, Eurycea bislineata, Gyrinophilus porphyriticus, P. glutinosus, and Pseudotriton ruber. Future surveys utilizing other techniques may reveal the presence of additional salamander species at this site.
Financial and operational benefit of improving patient status assignment and observation services across seven hospitals in the United States
Authors: Munsiff Amar V. , Dillon G. Scott
Published: May 2021

Objective: This aim of this project was to assess, develop and implement a paradigm for patient status assignment and more efficiently provide observation services. Patients who require hospitalization in the United States may remain an outpatient receiving observation services in the hospital, instead of inpatient status. Accurate and justifiable designation of patients to the right classification is of paramount importance because observation stays are reimbursed significantly less than inpatient admissions, incurring financial losses for hospitals, and sometimes patients.Methods: We reviewed the processes for patient status assignment and observation service delivery at seven hospitals over a 12 month period for each facility between February 2017 and December 2020, conducted interviews with key stakeholders, and reviewed medical records for medical necessity documentation and accuracy of patient status designation. We implemented a bundle of interventions to improve accurate patient status assignment and operational performance, such as the length of stay and proportion of patients undergoing status changes.Results: At all hospitals we achieved decreases in the proportion of patients assigned to observation services (38% to 17%, p < .001), average observation patients’ length of stay (from 34 to 23 hours), and average daily observation census (from 24 to 12 patients). The accuracy of initial status assignment and medical necessity documentation increased, with a decrease in the proportion of hospitalized patients undergoing any status change (p < .001 for all). The annual post-intervention financial gain ranged from $2.5M to $20.8M.Conclusions: A comprehensive bundle of interventions achieved large operational and financial improvements in observation service delivery at hospitals of various sizes in the US.
Análise da Experiência dos Usuários da plataforma virtual Balcão de Oportunidades Birigui
Authors: Boni Cláudio Roberto , Silva Conrado Renan da , Medina Camila , Pires Mariana Petruccelli , Paschoarelli Luis Carlos , Zitkus Emilene
Published: May 2021

Atualmente, sites de busca e oferta de emprego têm se tornado importantes artefatos comunicacionais que auxiliam indivíduos na recolocação no mercado de trabalho. O presente estudo busca avaliar a experiência do usuário (UX) frente ao Site do Balcão de Oportunidades da Prefeitura Municipal de Birigui, SP. Participaram da pesquisa indivíduos desempregados (n=5) que já estavam cadastrados no sistema. O estudo apontou uma série de oportunidades de melhoria no design da plataforma, que teria impacto direto na experiência dos usuários.
Analysis of the Basic Science Questions on the Orthopaedic In-Training Examination From 2014 to 2019
Authors: Shen Tony S. , Driscoll Daniel A. , Ellsworth Bridget K. , Premkumar Ajay , Lebrun Drake G. , Bostrom Mathias P. G. , Cross Michael B.
Published: May 2021

Introduction:

The Orthopaedic In-Training Examination (OITE), produced by the American Academy of Orthopaedic Surgeons (AAOS), plays an important role in the educational mission of orthopaedic residency programs nationwide. An up-to-date understanding of this examination is critical for programs to develop an appropriate curriculum and for individuals to identify learning resources. This study presents an updated analysis of the basic science section of the OITE from 2014 to 2019.

Methods:

All questions from the OITE from 2014 to 2019 were reviewed. Each question from the basic science section was categorized by topic and taxonomy. The use of radiographic images or other clinical media was recorded. The reference section was analyzed for bibliometric factors. Pearson chi-square tests were used as appropriate for statistical comparison.

Results:

In total, 185 of 1,600 questions in the basic science section were used over the 6-year study period (11.6%). The proportion of basic science questions ranged from 10.7% to 12.0% from year to year. The most frequently tested topics were cellular and molecular biology (23.8%), physiology/pathophysiology (16.8%), and pharmacology (10.8%). There was an increase in the number of biostatistics questions from 2017 to 2019 compared with the number from 2014 to 2016 (P = 0.02). The most common taxonomic category was knowledge recall (89.7%). A total of 383 references were cited from 122 sources. The 3 most common sources accounting for 44.4% of all citations were produced by the AAOS.

Discussion:

The basic science section of the OITE accounts for approximately 11% of all questions, with the most common taxonomy being knowledge recall (89.7%). Recent tests have emphasized biostatistics, highlighting the importance of incorporating biostatistics into residency education. Reference materials produced by the AAOS were highly cited in this section.
Potential Benefits of Limited Clinical and Radiographic Follow-up After Surgical Treatment of Ankle Fractures
Authors: Friedman Lisa G. M. , Sanchez Daniela , Zachos Terri A. , Marcantonio Andrew , Audet Megan , Vallier Heather , Mullis Brian , Myers-White Adam , Kempton Laurence , Watts Jeffrey , Horwitz Daniel S.
Published: May 2021

Introduction:

Ankle fractures are one of the most prevalent musculoskeletal injuries, with a significant number requiring surgical treatment. Postoperative complications requiring additional interventions frequently occur during the early postoperative period. We hypothesize that there is a limited need for routine clinical and radiographic follow-up once the fracture is deemed healed.

Methods:

IRB approval was obtained at four academic trauma centers. A retrospective chart review was done to identify adults with healed unimalleolar and bimalleolar ankle fractures treated surgically with at least 12 months of follow-up. Based on postoperative radiographs, changes in fracture alignment and implant position from radiographic union to final follow-up were documented. The average reimbursement for a final follow-up clinic visit and a set of ankle radiographs were estimated.

Results:

A total of 140 patients met inclusion criteria. The mean age at injury was 49.5 years, and 67.9% of patients were female. The mean time to healing was 82.2 days (±33.5 days). After radiographic healing, one patient had radiographic changes but was asymptomatic and full weight bearing at their final follow-up. On average, our institution was reimbursed $46 to $49 for a follow-up clinic visit and $364 to $497 for a set of ankle radiographs.

Conclusion:

Given the average time to healing, there is limited utility in routine radiographic and clinical follow-up beyond 16 weeks in asymptomatic patients. In our series, this would result in a savings of $950 to $1,200 per patient. However, after ankle fractures were deemed healed, 0.7% patients had radiographic evidence of a change in implant position. Documenting this change did not modify the immediate course of fracture treatment. Surgeons will need to balance the need for routine follow-up with the potential economic benefits in reducing costs to the healthcare system.
MOR and MOE of Serbian Spruce (Picea omorika Pančić/Purkyně) Wood from Natural Stands
Authors: Petrović Danijela , Dukić Vojislav Dukić , Popović Zdravko , Todorović Nebojša
Published: May 2021

The paper presents the results of testing the bending stress of Serbian spruce wood from natural stands. In testing the samples, in addition to the modulus of rupture, the bending stress at the proportionality limit, the ratio between the stress at the proportionality limit and the modulus of rupture as well as the modulus of elasticity of wood were determined. The study included nine trees from natural stands, and a total of 261 samples were tested. Regression analysis determined the dependences of these mechanical properties on the annual ring width, the proportion of late wood and wood density, as well as the dependence of the modulus of elasticity on the modulus of rupture.
AN OSCILLATiON THEOREM FOR A NEUTRAL DIFFERENCE EQUATION WITH POSITIVE AND NEGATIVE COEFFICIENTS
Authors: LI WAN-TONG , CHENG SUI-SUN
Published: May 2021

An oscillation criterion is derived which supplements the oscillation theorems dervied in [1].
Foreword to Special Issue
Authors: McCarthy Judith , Condell Joan
Published: May 2021

According to the International Council of Museums (ICOM, https://icom.museum/en/) current definition, “A museum is a non-profit, permanent institution in the service of society and its development, open to the public, which acquires, conserves, researches, communicates and exhibits the tangible and intangible heritage of humanity and its environment for the purposes of education, study and enjoyment.” As we move into the third decade of the 21st century, cultural heritage institutions throughout the world are using innovative digital solutions to enhance their work in all areas and also in how they communicate and exhibit heritage. This journal Special Issue presents articles that show examples and case studies demonstrating how invention and innovation can successfully take place when Museums and Digital Media converge.
The Acropolis on the Immersive Web
Authors: Engberg Maria , Bolter Jay David , Freeman Colin , Liestøl Gunnar , MacIntyre Blair
Published: May 2021

We report here on an application of reality media (virtual and augmented reality) to digital cultural heritage. The particular challenge we address is: how to combine VR and AR to bridge the gap between the center (the museum housing cultural artifacts) and periphery (the heritage site where the artifacts were found) while at the same time attending to, even enhancing, the aura of both artifacts and sites? Our proposed solution is to implement the cultural heritage technique known as situated simulation (sitsim) in combination with a social virtual environment called Hubs. Our case study is a sitsim of the Acropolis in Athens, which can function on location and remotely and offers real-time conferencing capabilities for its participants.
Comparison of Changes in Incisors Inclination and Dental Arch Dimensions in Damon and MBT Systems Using Dolphin Software
Authors: Eslami Neda , Sharifi Farid , Nasseri Athar , Jahanbin Arezoo
Published: May 2021

Background: There is great controversy regarding the effect of MBT and Damon bracket systems on dental arch dimensions and incisor position. Objectives: We aimed to study the effects of two different brackets (MBT and Damon) on dental arch dimensions and incisors position after orthodontic treatment. Methods: In this retrospective study, the records of 20 patients who underwent orthodontic treatment with MBT or Damon bracket systems were studied. All patients had class I skeletal and dental malocclusion and were treated without extraction. The patients were treated either with Damon or MBT bracket systems (n = 10). Lateral cephalograms were traced using the Dolphin software to determine the position of incisors. In addition, transverse dimensions of dental arches were measured on occlusal photographs. Fishers’ exact test, independent-test, Man-Whitney, paired t-test, and Wilcoxon were used for statistical analysis. P < 0.05 was set as significant. Results: There was no significant difference between the two groups regarding age, sex, and initial values of the variables studied. U1-Apog (mm), upper inter-canine, lower inter-second premolar distance showed a significant difference before and after treatment in the Damon system. However, no significant difference was observed between initial and post-treatment values in the MBT group. L1-Apog (°), IMPA (°), maxillary inter-first and second premolars, inter-canine, and mandibular inter-canine distance was higher in the Damon system after treatment compared to MBT. Changes of the upper and lower transverse dimensions of the dental arches and the incisor positional did not reveal a notable difference in the Damon and MBT systems (P > 0.05). Conclusions: There was no significant difference regarding changes in dental arches and incisor positions between the Damon and MBT systems.
Handicapping Rules and Performance of Sailing Yachts
Authors: Letcher John S.
Published: May 2021

The structure of some past and present rules is discussed and the general problem of optimum performance under the rule is considered. This requires a rational performance model, which would itself form the most equitable rating rule possible under the existing level of technical understanding of mechanics of sailing.

The theory of sailboat performance estimates is outlined and surveyed. New theories are presented on the performances of geometrically similar vessels and on the implications of optimum sail trim. Two rational ways are proposed for averaging performance over a probability distribution of operating conditions appropriate to different types of races. The theory suggests a new form for a rule, in which multiple ratings are assigned characterizing average potential speeds in various ranges of operating conditions.
Some Observed Effects of Foil Control on Hydrofoil Sailing Vehicle Performance
Authors: Bradfield W. S.
Published: May 2021

Fixed lifting foil sailing vehicles are at about the same stage of development as were catamarans about 15 years ago. So far it has been established (experimentally) that fixed foil vehicles do “fly”; that there exists an optimum take off speed corresponding to each given hull configuration; that for a given catamaran configuration with and without foils in true wind speeds in excess of 15 knots; and that the observed improvement is not equal to that predicted.

The present paper concludes on the basis of timed runs that the discrepancy between predicted ideal and observed performance is due to lack of control of vehicle stability and balance in the hard and gusty winds required for top speed. Herein, are developed some simple ideas for improving sailing hydrofoil performance with minimal helmsman control of foil incidence and dihedral. The design and development of two hydrofoil sailboats incorporating these ideas is described and the results of comparative predicted and measured performance of one of them is presented.
Debating real integrated territorial cooperation approaches to post-2020 EU policies: the challenges arising from COVID-19 from the perspective of the Association of European Border Regions (AEBR).
Authors: Guillermo Ramirez Martin
Published: May 2021

The European Union (EU) territorial development and cohesion have been supported by European institutions for decades, but they currently face a critical moment: the COVID-19 pandemic and European coordination gaps have to be added to previously-existing difficulties, such as the growing climate-related and demographic challenges, and the wave of Euroscepticism, nationalism and populism. Viruses do not recognise borders, but the EU is still divided between those thinking that the economy should prevail over politics and those thinking otherwise. European citizens living in border areas know very well that we need a common approach (and a stronger commitment) to the preservation of our values and rights, as well as to the definitive positioning of the EU as a global player. Integration starts at the bottom and moves across borders. The legacy of cohesion and territorial stability that the EU leaves for future generations will depend on how it protects and strengthens cross-border cooperation at this stage.
Évaluation par compétences : les préoccupations des enseignants en matière d’évaluation au cours d’une expérimentation des « classes sans notes » dans un collège français
Authors: Saillot Éric
Published: May 2021

Cet article s’appuie sur une recherche collaborative menée de 2016 à 2018 dans un collège français sur les « classes sans notes », expérimentation qui propose une évaluation des élèves par compétences, et non plus avec des notes chiffrées. Notre problématique vise à mieux comprendre les préoccupations des enseignants qui doivent évaluer sans le système de notation sur 20. Nous avons mené 1 entretien avec 5 cadres dirigeants, 4 groupes de discussion avec 26 enseignants et des réunions collectives, dans l’esprit des « disputes professionnelles réglées » de Clot (2006). Nous avons identifié six types de préoccupations relatives aux pratiques évaluatives par compétences.
Raconter sa biographie langagière en la géolocalisant : le récit cartographique numérique comme outil de formation en didactique des langues secondes
Authors: Bedou Stéphanie , Hamel Marie-Josée
Published: May 2021

Cet article détaille une étude portant sur le récit cartographique numérique comme outil de formation en didactique des langues secondes permettant de raconter sa biographie langagière de manière dynamique et multimodale. Pour mener à bien cette étude, nous avons analysé un corpus de biographies langagières (N=10) produites avec le logiciel StoryMap par des étudiants bilingues en formation en didactique des langues secondes. Les résultats de notre analyse thématique font ressortir les caractéristiques de composition du récit biographique numérique et de l’expression des expériences langagières formelles et informelles d’apprentissage de ces étudiants qui se destinent à enseigner le français langue seconde. Ils mettent en évidence que ce type de tâche d’écriture médiatique leur a permis de matérialiser (par l’écriture, l’image, la géolocalisation) leur répertoire langagier, d’expliciter leurs rapports aux langues et de prendre du recul sur leur parcours de formation.
The first private newspaper of the Taurida Governorate– "Crimean Leaflet"
Authors: Khas'yanova Arzy Dilyaverovna
Published: May 2021

This article examines the establishment of private periodical press of the Taurida Governorate in the late XIX century. The object of this research is the first private newspaper – “Crimean Leaflet”. The author explores the socioeconomic processes and censorship conditions, which affected the emergence of the Crimean private periodicals. An overview is given to the historiography and sources used in this work. The first part of the article studies the sociopolitical and cultural-historical prerequisites for the emergence of mass media in the governorate. The second part examines the process of opening and operation of the newspaper, its outline, biography of the publisher, as well as composition of the editorial board. The third part reveals the subject matter of the published materials and the peculiarities of interaction of the newspaper with the provincial administration and censorship authorities. The author also analyzes the reasons why the newspaper was shut down. In conclusion, the author reviews the role of the newspaper in formation of private provincial press, and its impact upon public relations in the Taurida Governorate. The scientific novelty consists in introduction into the scientific discourse of previously unstudied archival materials, as the historiography virtually had no records on the newspaper and the personality of the publisher. This work contributes to studying the development of private press in the Taurida Governorate, as well as reveals certain details of state policy with regards to provincial press in the late XIX century.
Assessment of “maturity” of the taxpayer's internal control system for tax monitoring purposes
Authors: Berezina Elena Vladimirovna , Balandina Anna Sergeevna , Belomyttseva Ol'ga Svyatoslavovna
Published: May 2021

The internal control system is examined as a variety of internal control of an economic entity on the one hand, and as the foundation for transitioning towards tax monitoring on the other. Such approach allows assessing this structure from the perspective of taxpayers, as well as from the standpoint of implementation of public function of tax control. The object of this article is the process of improving internal control system of tax obligations by the taxpayer in the conditions of digitalization of tax administration. The subject of this article is the theoretical aspects of internal control as an administrative function, as well as comparative analysis of the Russian “internal control” system with the classical COSO model. The scientific novelty consists in comprehensive research of the internal control of tax obligations, determination of its essential characteristics,  and assessment of the consequences of formalization of requirements thereof, which led to the conclusion on transformation of the internal control of the taxpayer from the area of reputational merits of the economic entity and internal administration instruments to the subject of public control by tax authorities in tax monitoring processes. It remains to be seen whether state interference in such delicate sphere of activity of an economic entity as internal control is justified. The goal of this research consists in the analysis of the effective requirements of the Federal Tax Service of Russia from the perspective of possibility of their implementation by the particular taxpayers. The article provides the examples of assessment of certain components of the internal control system based on the criteria set by the Federal Tax Service of Russia. The author formulates the definition of control procedure, carries out classification of the aforementioned criteria; develops the examples of effective design of some controls; as well as presents the examples of assessment of IT systems from in the context of extended requirements of the Federal Tax Service of Russia.
Limited inhibition of multiple nodes in a driver network blocks metastasis
Authors: Yesilkanal Ali Ekrem , Yang Dongbo , Valdespino Andrea , Tiwari Payal , Sabino Alan U , Nguyen Long Chi , Lee Jiyoung , Xie Xiao-He , Sun Siqi , Dann Christopher , Robinson-Mailman Lydia , Steinberg Ethan , Stuhlmiller Timothy , Frankenberger Casey , Goldsmith Elizabeth , Johnson Gary L , Ramos Alexandre F , Rosner Marsha R
Published: May 2021

Metastasis suppression by high-dose, multi-drug targeting is unsuccessful due to network heterogeneity and compensatory network activation. Here, we show that targeting driver network signaling capacity by limited inhibition of core pathways is a more effective anti-metastatic strategy. This principle underlies the action of a physiological metastasis suppressor, Raf Kinase Inhibitory Protein (RKIP), that moderately decreases stress-regulated MAP kinase network activity, reducing output to transcription factors such as pro-metastastic BACH1 and motility-related target genes. We developed a low-dose four-drug mimic that blocks metastatic colonization in mouse breast cancer models and increases survival. Experiments and network flow modeling show limited inhibition of multiple pathways is required to overcome variation in MAPK network topology and suppress signaling output across heterogeneous tumor cells. Restricting inhibition of individual kinases dissipates surplus signal, preventing threshold activation of compensatory kinase networks. This low-dose multi-drug approach to decrease signaling capacity of driver networks represents a transformative, clinically relevant strategy for anti-metastatic treatment.
Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors
Authors: Beekhof Gerrit Cornelis , Osório Catarina , White Joshua J , van Zoomeren Scott , van der Stok Hannah , Xiong Bilian , Nettersheim Ingo HMS , Mak Willem Ashwin , Runge Marit , Fiocchi Francesca Romana , Boele Henk-Jan , Hoebeek Freek E , Schonewille Martijn
Published: May 2021

Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features are at the core of the modular organization of the cerebellum. Previously, we showed that firing activity of PCs differs between ZebrinII-positive and ZebrinII-negative cerebellar modules (Zhou et al., 2014; Wu et al., 2019). Here, we investigate the timing and extent of PC differentiation during development in mice. We found that several features of PCs, including activity levels, dendritic arborization, axonal shape and climbing fiber input, develop differentially between nodular and anterior PC populations. Although all PCs show a particularly rapid development in the second postnatal week, anterior PCs typically have a prolonged physiological and dendritic maturation. In line herewith, younger mice exhibit attenuated anterior-dependent eyeblink conditioning, but faster nodular-dependent compensatory eye movement adaptation. Our results indicate that specific cerebellar regions have unique developmental timelines which match with their related, specific forms of cerebellum-dependent behaviors.
Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation
Authors: Weber Daniel K , Reddy U Venkateswara , Wang Songlin , Larsen Erik K , Gopinath Tata , Gustavsson Martin B , Cornea Razvan L , Thomas David D , De Simone Alfonso , Veglia Gianluigi
Published: May 2021

Phospholamban (PLN) is a mini-membrane protein that directly controls the cardiac Ca2+-transport response to β-adrenergic stimulation, thus modulating cardiac output during the fight-or-flight response. In the sarcoplasmic reticulum membrane, PLN binds to the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA), keeping this enzyme's function within a narrow physiological window. PLN phosphorylation by cAMP-dependent protein kinase A or increase in Ca2+ concentration reverses the inhibitory effects through an unknown mechanism. Using oriented-sample solid-state NMR spectroscopy and replica-averaged NMR-restrained structural refinement, we reveal that phosphorylation of PLN’s cytoplasmic regulatory domain signals the disruption of several inhibitory contacts at the transmembrane binding interface of the SERCA-PLN complex that are propagated to the enzyme’s active site, augmenting Ca2+ transport. Our findings address long-standing questions about SERCA regulation, epitomizing a signal transduction mechanism operated by posttranslationally modified bitopic membrane proteins.
Fusion of text and graph information for machine learning problems on networks
Authors: Makarov Ilya , Makarov Mikhail , Kiselev Dmitrii
Published: May 2021

Today, increased attention is drawn towards network representation learning, a technique that maps nodes of a network into vectors of a low-dimensional embedding space. A network embedding constructed this way aims to preserve nodes similarity and other specific network properties. Embedding vectors can later be used for downstream machine learning problems, such as node classification, link prediction and network visualization. Naturally, some networks have text information associated with them. For instance, in a citation network, each node is a scientific paper associated with its abstract or title; in a social network, all users may be viewed as nodes of a network and posts of each user as textual attributes. In this work, we explore how combining existing methods of text and network embeddings can increase accuracy for downstream tasks and propose modifications to popular architectures to better capture textual information in network embedding and fusion frameworks.
Experimental indications of gardeners’ anecdotes that snails interfere with invasive slugs
Authors: Dörler Daniel , Dorn Verena , Widhalm Theresia , Horacek Micha , Heigl Florian , Euteneuer Pia , Leisch Friedrich , Frank Thomas , Zaller Johann G.
Published: May 2021

The invasive Spanish slug (Arion vulgaris) is an important pest species in agriculture and horticulture in Europe. In the last decades it has spread across the continent where it outcompetes native slug and snail species, thus posing a threat for biodiversity. A popular anecdote suggests to promote Roman snails (Helix pomatia) in gardens because they are able to controlA. vulgaris. We examined a potential interrelationship between these two species using a mesocosm experiment with lettuce plants.13C-15N stable isotope labelling of lettuce allowed us to investigate interactions betweenHelixandArionon weight gain/loss and herbivory. Additionally, we wanted to know whether different watering regimes (daily vs. every 3rd day watering of weekly amount) and earthworms alter these interactions. Egg predation ofHelixonArioneggs was further tested in a food-choice experiment.Arionshowed a five times higher herbivory per body mass thanHelixin a single-species setting. However, in mesocosms containing both species percentage of herbivory per body mass was significantly lower than inArion-only mesocosms, especially when watered every three days. Overall isotope uptake via eaten lettuce was unaffected by the presence of the other species. Only very little predation (three out of 200 eggs) ofHelixonArioneggs was observed. Our results provide no evidence for a clear dismissal or confirmation of the popular gardener’s anecdote thatHelixsnails have a negative effect onArionabundance or herbivory.
Identification of robust diagnostic and prognostic gene signatures in different grades of gliomas: a retrospective study
Authors: Liu Jieting , Zhang Hongrui , Zhang Jingyun , Bing Zhitong , Wang Yingbin , Li Qiao , Yang Kehu
Published: May 2021

Background

Gliomas are the most common primary tumors of the central nervous system. The complexity and heterogeneity of the tumor makes it difficult to obtain good biomarkers for drug development. In this study, through The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA), we analyze the common diagnostic and prognostic moleculer markers in Caucasian and Asian populations, which can be used as drug targets in the future.

Methods

The RNA-seq data from Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) were analyzed to identify signatures. Based on the signatures, the prognosis index (PI) of every patient was constructed to predict the prognostic risk. Also, gene ontology (GO) functional enrichment analysis and KEGG analysis were conducted to investigate the biological functions of these mRNAs. Glioma patients’ data in the CGGA database were introduced to validate the effectiveness of the signatures among Chinese populations. Excluding the previously reported prognostic markers of gliomas from this study, the expression of HSPA5 and MTPN were examined by qRT-PCR and immunohistochemical assay.

Results

In total, 20 mRNAs were finally selected to build PI for patients from TCGA, including 16 high-risk genes and four low-risk genes. For Chinese patients, the log-rank test p values of PI were both less than 0.0001 in two independent datasets. And the AUCs were 0.831 and 0.907 for 3 years of two datasets, respectively. Moreover, among these 20 mRNAs, 10 and 15 mRNAs also had a significant predictive effect via univariate COX analysis in CGGA_693 and CGGA_325, respectively. qRT-PCR and Immunohistochemistry assay indicated that HSPA5 and MTPN over-expressed in Glioma samples compared to normal samples.

Conclusion

The 20-gene signature can forecast the risk of Glioma in TCGA effectively, moreover it can also predict the risks of Chinese patients through validation in the CGGA database. HSPA5 and MTPN are possible biomarkers of gliomas suitable for all populations to improve the prognosis of these patients.