bluuebunny/crossref_metadata_2025 huggingface dataset:
Phosphoproteomics guides low dose drug combination of cisplatin and silmitasertib against concurrent chemoradiation resistant cervical cancer
Authors: George Irene A. , Sambath Janani , Dhawale R. E. , Singh Manisha , Trivedi Vinita , Venkataramanan R. , Chauhan Richa , Kumar Prashant
Published: November 2024

Phosphoproteomics of non-responders vs. responders in cervical cancer. Identified unique phosphosignatures and dysregulated pathways. Activation of CSNK2A1 in non-responders. Therapeutic target validated using silmitasertib.
Self-assembled rosette nanotubes from tetra guanine-cytosine modules
Authors: Hemraz Usha D. , Yamazaki Takeshi , El-Bakkari Mounir , Cho Jae-Young , Fenniri Hicham
Published: November 2024

Self-assembly of small molecules into supramolecular architectures is a sustainable alternative to new advanced material design.
Molecular-scale in-operando reconfigurable electronic hardware
Authors: Wang Yulong , Zhang Qian , Nickle Cameron , Zhang Ziyu , Leoncini Andrea , Qi Dong-Chen , Borrini Alessandro , Han Yingmei , del Barco Enrique , Thompson Damien , Nijhuis Christian A.
Published: November 2024

A dynamic molecular switch with 3 different functionalities makes it possible to reconfigure devices at molecular length scales and to access different memory states by simply changing the applied voltage.
Sustainable protocol for Cu-catalysed A3-coupling under solvent-free conditions
Authors: Chaturvedi Anjali , Sharma Vishal , Rawal Ravindra K. , Singh Manpreet , Singh Virender
Published: November 2024

A Cu-catalyzed three-component cascade reaction has been developed, involving ortho-alkynylaryl aldehydes, terminal alkynes and aliphatic amines/aromatic amines or diamines.
Homophenylalanine-derived benzo[1,4]diazepine-2,5-diones are strong bacterial quorum sensing inhibitors
Authors: Einsiedler Manuel , Bogojević Sanja Š. , Milivojević Dušan , Vojnovic Sandra , Milčić Miloš K. , Maslak Veselin , Matura Anke , Gulder Tobias A. M. , Nikodinovic-Runic Jasmina
Published: November 2024

This work describes the evaluation of the antimicrobial properties of benzo[1,4]diazepine-2,5-diones, revealing their interference with bacterial quorum sensing (QS). Activity-based structural optimisation resulted in highly active QS inhibitors.
Highly reversible Zn electrodeposition enabled by glutathione-protected copper nanoclusters for aqueous Zn-ion batteries
Authors: Wang Lu-Fan , Wang Xiao-Yuan , Xu Shu , Wu Zhou , Sun Guoqiang , Liu Xiao-Fei , Huang Ren-Wu , Zang Shuang-Quan
Published: November 2024

A novel strategy to construct stable dendrite-free Zn anodes using a carbon cloth current collector modified with glutathione (GSH)-protected Cu nanoclusters was presented.
Constructing vertically aligned ZIF-67 microrod arrays on carbon cloth with commercial-level mass-loading for high-performance supercapacitors
Authors: Bai Chenchen , Li Bingjun , Li Dejun , Han Yan , Wang Caiyun
Published: November 2024

A solution immersion method is developed to construct ZIF-67 microrod arrays on CC with commercial-level mass-loading, which offers a superior capacitive performance.
Charge-transfer mediated J-aggregation in red emitting ultra-small-single-benzenic meta-fluorophore crystals
Authors: Mandal Mrinal , Mardanya Sukumar , Saha Arijit , Singh Manjeev , Ghosh Swarnali , Chatterjee Tanmay , Patra Ramen , Bhunia Surojit , Mandal Saptarshi , Mukherjee Soumen , Debnath Rahul , Reddy C. Malla , Das Mousumi , Mandal Prasun K.
Published: November 2024

CT-mediated J-aggregation leads to the red emission in crystals of ultra-small single benzenic meta-fluorophores.
Surfactant-influenced biosorption as a sustainable and effective way for the eradication of environmental pollutants: a review
Authors: Biswas Subhadeep , Nayak Ashish Kumar , Pal Anjali
Published: November 2024

Surfactant assisted biosorption is a powerful sustainable remediation technique for pollution abatement from water medium. The current review highlights the latest developments that took place in this field.
Multicolor solid-state fluorescence and multicolor afterglow carbon dots: preparation, luminescence regulation, and applications
Authors: Fu Qiang , Zhang Jianye , Zhang Kailin , Sun Shouhong , Dong Zhanhua
Published: November 2024

We review multicolor solid-state fluorescence and multicolor afterglow carbon dots (CDs) in perspectives of synthesis methods, luminescence modulation mechanisms, and applications.
Multifunctional azo-BODIPY-functionalised upconversion nanoparticles as sensors of hypoxia in biological environments
Authors: Yao Jingke , Simón-Fuente Silvia , Lopez-Peña Gabriel , Gómez-Pastor Silvia , Guisan-Ceinos Santiago , Marin Riccardo , Martín Rodríguez Emma , Jaque Daniel , Sanz-Rodríguez Francisco , Ribagorda Maria , Ortgies Dirk H.
Published: November 2024

A near-infrared excitable hypoxia-sensitive sensor was designed with upconverting nanoparticles and an azo-dye, absorbing their visible emissions. In hypoxic environments, the azo bond is reduced, recovering the nanoparticles’ upconversion emissions.
Exploring π-extended chiral ligands for the direct detection of circularly polarized light in 2D chiral perovskites
Authors: Jeon Taesu , Yeo Doyeong , Choi Wonbin , Kim Hongki , Jung In Hwan , Oh Joon Hak
Published: November 2024

In this work, we synthesized π-extended phenyl based chiral organic ligands and successfully constructed larger-sized chiral perovskites, enabling the detection of circularly polarized light.
Convective mixing in distant and close-in giant planets
Authors: Polman J. , Mordasini C.
Published: November 2024

Recent structure models of Jupiter suggest the existence of an extended region in the deep interior with a high heavy element abundance, referred to as a dilute core. This finding has led to increased interest in modelling the formation and evolution processes with the goal of understanding how and under what circumstances such a structure is formed and retained, to in turn better understand the relation between atmospheric and bulk metallicity. We modelled the evolution of giant planets, varying various parameters relevant for the convective mixing process, such as the mixing length parameter and the size of the mesh, and parameters related to the general evolution, such as the orbital distance and the initial luminosity. We in particular studied hot Jupiters and find that the effect of bloating on the mixing process is small but can in some cases inhibit convective mixing by lowering the intrinsic luminosity for a given entropy. Semi-convection can significantly lower the extent of a dilute core if it is strong enough. We find that dilute cores are unable to persist for initial luminosities much higher than ~3 × 103 LJ for a Jupiter-like planet for the initial heavy element profiles we studied. From this we conclude that, based on our model, it is unlikely that a large number of giant planets retain a dilute core throughout their evolution, although this is dependent on the assumptions and limitations of our method. Future work should focus on improving the link between formation and evolution models so that the mixing process is accurately modelled throughout a planet’s lifetime and on improving the understanding of how to model convection near radiative-convective boundaries.
Forbidden emission line spectro-imaging of the RU Lupi jet and low-velocity component
Authors: Birney M. , Whelan E. T. , Dougados C. , Pascucci I. , Murphy A. , Flores-Rivera L. , Flock M. , Kirwan A.
Published: November 2024

The first images of the jet and low-velocity component (LVC) from the strongly accreting classical T Tauri star RU Lupi are presented. Adaptive optics-assisted spectro-imaging of forbidden emission lines was used. The main aim of the observations was to test the conclusion from a recent spectro-astrometric study that the narrow component (NC) of the LVC traces a magnetohydrodynamic (MHD) disk wind, and to estimate the mass-loss rate in the wind. The structure and morphology support a wind origin for the NC. The upper limit to the launch radius and semi-opening angle of the wind in [O I] λ6300 emission are estimated to be 2 au and 19°, in agreement with MHD wind models for high accretors. The height of the [O I] λ6300 wind-emitting region, a key parameter for the derivation of the mass-loss rate, is estimated for the first time at ∼35 au, giving Ṁout = 2.6 × 10−11 M⊙ yr−1. When compared to the derived mass-accretion rate of Ṁacc = 1.6 × 10−7 M⊙ yr−1, the efficiency in the wind is too low for the wind to contribute significantly to the angular momentum removal.
Growth performance of Litopenaeus vannamei in low salinity cultivation with different natural feeds
Authors: Prasetyo Dony , Hakim Riza Rahman , Sutarjo Ganjar Adhywirawan , Purnomo Hari , Ariansyah Firdaus
Published: November 2024

The development of vanamei shrimp farming in freshwater aims to expand economic and social opportunities. However, raising shrimp outside their natural habitat presents challenges. This study aimed to identify the best acclimatization method, the lowest salinity level that supports shrimp growth, and suitable natural feeds for low-salinity conditions. The acclimatization process involved five treatments with three repetitions, gradually reducing salinity by 2 g/L and 1 g/L daily to reach 0, 3, 5, 8, and 10 g/L. A total of 1,000 postlarvae-10 were reared in aquariums for a month, followed by 300 shrimp in 1.5-meter tarpaulin ponds for two months. Shrimp were fed pellets, earthworms, and trash fish. The results showed that the best growth and survival rates at the lowest salinity were achieved at 5 g/L, with a survival rate of 90% and a length of 5.9 cm by DOC-30. Feeding shrimp with African Nightcrawler earthworms resulted in higher average body weight (ABW) and average daily growth (ADG), with survival rates and feed conversion ratios (FCR) comparable to those fed pellets and trash fish.
Halal human capital development strategy in Madura: ANP-SWOT approach
Authors: Dzikrulloh  , Mayvani Titov Chuk’s
Published: November 2024

Sharia economic growth in Indonesia has increased significantly, at present, the Indonesian human capital index remain relatively low. Hence, research on human capital is necessary to close the gap. This research is aimed to provide a significant strategy for human capital development in the halal industry, providing as a crucial guideline for policymakers involved in the economic development of Shariah in Indonesia. The research approach applied is qualitative, using the Analytic Network Process (ANP) method through the SWOT network framework (Strength-Weakness-Opportunity-Threat). The study investigates several types of strategies and steps that focus on the interrelationships and feedback of elements within clusters using both qualitative and quantitative methods. This approach collects the opinions of professionals with deep expertise in the topic. The data was collected from 15 respondents who are specialists in academia, regulation, and practice, conducting study on Madura Island. The experts' opinions were assessed using Super Decisions software and Microsoft Excel to determine priority values, which were further examined in the priority strategy. The research identifies the SO (Strength Opportunity) strategy for enhancing halal human capital development in three stages. Short-term goals include enhancing the infrastructure of the halal ecosystem. Medium-term objectives involve improving education quality, optimizing synergies, establishing a halal management laboratory, and enhancing promotion and socialization. Long-term strategies focus on strengthening capacity building, improving halal training programs, and establishing expert certification facilities.
Biosynthesis silver nanoparticle using Bacillus thuringiensis strain BT2 and its potential use against Spodoptera frugiperda J.E. Smith (Lepidoptera: Noctuidae)
Authors: Khoiri Syaiful , Rahmawati Isna Nur , Djunaedy Achmad , Pawana Gita , Megasari Dita
Published: November 2024

Spodoptera frugiperda J. E. Smith is a new invasive pest in Indonesia and is reported to be invasive almost worldwide. One of the controls carried out is using synthetic pesticides. However, using synthetic pesticides causes problems, such as resistance, product and environment contamination, and environmental damage. Nanotechnology is a modern research field that has the potential to be used as an alternative pest control technology, one of which is silver nanoparticles. However, the biological synthesis of nanosilver is still limited. This research aims to determine the ability of Bacillus thuringiensis as a reductant in the formation of silver nanoparticles and to test its activity as an insecticide against S. frugiperda. The method was conducted by detecting reductant produced by B. thuringiensis by mixing 5 mL of 0.01 M AgNO3 with 45 mL each of supernatant and bacterial pellet. The mixed solution was then shaken for 3 days at a rotation speed of 150 rpm until a color change occurred in the solution. The AgNP synthesis results were characterized using a UV-Vis spectrophotometer. The results showed that based on spectrophotometer measurements it was confirmed that AgNPs synthesized with B. thuringiensis reductants showed a maximum absorption peak at a wavelength of 412.9 nm. AgNPs were tested on S. frugiperda using various concentrations. The highest mortality values were obtained in the treatment of 10% AgNPs with larval mortality of 47%. The LC50.90 values of 10.99% and 91.83%. The LT50.90 values were 78.10 hours and 145,12 hours. These results indicate that bio-synthesize silver nanoparticles have the potential to be used as a bioinsecticide.
Student habituation program in elementary school: The orientation of cocurricular activities in developing characters of pancasila students
Authors: Pangestu Widya Trio , Sumadi Conny Dian
Published: November 2024

This study is aimed at studying the student habituation program in elementary school in developing characters of Pancasila students. Profile of Pancasila students involves worshipping God, having good attitude, implementing global unity-in-diversity, being cooperative, being independent, being critical, and being creative. In this study, a qualitative study is conducted which using observation, interview, and theoretical study in collecting data. The samples are elementary school teachers, students and parents whose schools have implemented consistent and systematic student habituation program in integrating the values of Pancasila. The results of this study show that it is found that the habituation program was implemented in some activities, such as ceremony, religious activities, cleaning environment, communal work, creating products, discussion, shaking hands, greeting, and smiling. Through the holistic and integrated habituation program, students can understand, internalize, and apply the values of Pancasila in their daily life. However, it is necessary for stakeholders to provide suggestions for the development of curriculum and habituation program. Moreover, the program can be considered as the main reference for policy makers and practitioners to strengthen the values of Pancasila characters in Indonesia.
A Policy Analysis of the implementation of local content curriculum for SMP/MTs in Jepara Regency
Authors: Al Mufti Alex Yusron , Setyawan Agung
Published: November 2024

This study evaluates the implementation of SMP/MTs local content curriculum policies (LCCP) in Jepara Regency. It includes an analysis of Regional Regulation No. 1 of 2018 formulation, evaluation of local government policies regarding SMP/MTs local content curriculum, analysis of policy impact on local content curriculum, and sustainability analysis to the SMA/MA/SMK level. The qualitative evaluation method was employed, focusing on Jepara District Government's policy. Data were sourced from the Department of Youth and Sports (Dispora), DPRD, SMP/MTs, and the furniture industry. Data collection methods included in-depth interviews, document studies, surveys, observations, and questionnaires, validated internally and externally through qualitative data analysis. Findings indicate Jepara Regional Government Policy formulation involved various stakeholders and met community representation and scholarly standards. However, the local government's policy implements Curriculum 2013, integrating carving skills into Arts and Crafts Lessons, contrary to the local regulation mandating carving as a separate subject in SMP/MTs. Non-compliance impacts limited involvement of the younger generation in tradition development, risking the decline of local culture. For sustainability, local regulations are needed for teaching carving content in SMA/MA/SMK, as these graduates contribute to the workforce. This study emphasizes aligning policy with practice to preserve and promote local traditions and skills across educational levels.
Madurese fathers are parents too: Their roles in complying children's rights
Authors: Oktavianingsih Eka , Fitroh Siti Fadjryana , Maf’ula Himmayatul , Latif M. Abdul
Published: November 2024

Parents play a pivotal role in the growth and development of children. Previous research highlights the significant benefits associated with fathers' involvement in parenting. This study aims to assess the perceptions of Madurese fathers regarding the fulfillment of children's rights and to identify predictors influencing these perceptions. Employing an explanatory sequential research design, this study combines both quantitative and qualitative methods to explore Madurese fathers' perspectives. A total of 75 Madurese fathers participated in the study, completing a questionnaire that gauged their perceptions and provided demographic information. Prior to its use, the questionnaire underwent thorough validity and reliability testing. Additionally, interviews were conducted to gain deeper insights into the factors influencing fathers' perceptions. The quantitative analysis revealed that Madurese fathers generally hold positive perceptions (M=125.40789) regarding the fulfillment of children's rights. Qualitative findings indicated the shapes of the Madurese fathers in complying the children rights. This result of this study sheds light on Madurese fathers' perceptions of children's rights fulfillment and the factors contributing to parental roles and responsibilities in child development. This study also offer conceptual contribution in escalating parent’s awareness through children rights and child-friendly parenting method. According to condition in 21st century, consideration of religious, culture, and tradition views through children rights need to be implied.The findings of this research provide valuable insights for stakeholders aiding in the formulation of strategies to enhance parental involvement and support in children's growth and well-being.
Ecological Study and Habitat Characteristics of Sea Cucumbers (Holothuroidea) in Kamal and Socah Waters, Bangkalan Regency, Madura, Indonesia
Authors: Pramithasari Febi Ayu , Triajie Haryo , Wardhana Arinda Widya
Published: November 2024

Sea cucumbers are economically valuable commodities in Bangkalan waters and play a crucial ecological role in marine ecosystems. Understanding their habitat characteristics and ecological health is essential for sustainable management and conservation. This study aims to assess the ecological health and habitat characteristics of sea cucumbers in Kamal and Socah waters of Bangkalan Regency, Madura, Indonesia. Sea cucumbers were collected using hand collection methods during low tide. Water quality and substrate conditions at the collection sites were evaluated to ensure suitability for sea cucumbers. The study identified four sea cucumber species: Phyllophorus sp., Phyllophorella spiculata, Acaudina leucoprocta, and Colochirus quadrangularis. Diversity indices were low (<1), with Kamal ranging from 0.2 to 0.86 and Socah from 0 to 0.87. Dominance values were medium to high (0.5-1), except in Socah area 5 where dominance was low (0.48). Phyllophorus sp. was the most dominant species, comprising 58% of the total biota in both locations. The low diversity and varying dominance of sea cucumber species are attributed to the sandy sediment and suitable water quality in both locations. These findings highlight the need for continued monitoring and management to ensure the sustainability of sea cucumber populations in Bangkalan waters.
Restorative justice approach in village fund corruption in Pamekasan Regency
Authors: Habibullah Abd. Wachid , Muti’ah Dewi , Sugiarsih Dewi
Published: November 2024

Village fund is provided by the central government to support the development of infrastructure, people empowerment, and public service in each village in Indonesia. However, in practice, there have been misuses in the management of village funds that have led to corruption. At least hundreds of suspects, including village heads and officials, have been arrested for corruption of village funds. Consequently, the operation of the village government and its development has stalled. A special approach from the concept of restorative justice is needed to resolve the problem. This research was conducted to explore the use of the restorative justice concept approach in resolving village fund corruption cases. This research applies juridical-empirical research method and sociological juridical approach. The types of data used were primary and secondary data. Primary data was obtained from respondents' information including experts through interviews. Meanwhile, secondary data was obtained from documents of related laws and regulations, scientific journals, and others. The research location was in Pamekasan Regency, Madura Island, East Java Province. The results of this research are expected to illustrate the ideal concept of the restorative justice approach and how it can be used to identify case characteristics in handling corruption of village funds. In the future, this research is expected to generally prevent other acts of manipulation and village funds can be optimized for village development.
Adaptation of the organizational culture profile scale into Indonesian: A psychometric study
Authors: Utomo Triyo , Handoyo Seger , Fajrianthi
Published: November 2024

The Organizational Culture Profile (OCP) is widely utilized to assess organizational culture. However, there has been no documented scientific study on its adaptation to the Indonesian language in reputable international journals. This study aims to adapt the OCP scale to Indonesian and evaluate its psychometric properties. A quantitative methodology was employed, involving 453 participants from government organizations in East Java, Indonesia. Confirmatory Factor Analysis (CFA) utilizing a five-factor model demonstrated that the measurement model met various fit indices, indicating a strong alignment between the model and field data. Additionally, the analysis confirmed the OCP scale's convergent validity. These findings affirm that the Indonesian version of the OCP scale is a valid research instrument.
Nuclear Magnetic Resonance and High-Speed Centrifugation for Gas-Water Relative Permeability Curve of Low-Permeability and Tight Sandstone
Authors: Yang Fenglai , Liu Huaxun , Gao Shusheng , He Sijie , Fang Feifei , Wang Cuili , Ye Liyou , Zhou Kun , Yang Xuejun , An Weiguo
Published: November 2024

Gas-water relative permeability curve is the foundation of gas reservoir dynamic analysis and numerical simulation. It is generally obtained through gas displacing water experiment. Referring to the existing national standards, gas-water relative permeability test is carried out for low-permeability and tight sandstone. The flow is discontinuous and the curve smoothness is poor, which affects the application of gaswater relative permeability curve. Based on the comparative analysis of a large number of mercury injection and NMR experimental results of low-permeability and tight sandstone, a method to characterize the throat radius distribution of low-permeability tight sandstone based on NMR T2 spectrum is explored. Combined with high-speed centrifugal experiment, the calculation formulas of core water saturation, phase relative permeability of gas-water under different centrifugal force are established. A new method of “nuclear magnetic resonance + high-speed centrifugation” for gas-water relative permeability curve test of lowpermeability and tight sandstone is formed, and the test is carried out on Sulige low-permeability tight sandstone core. The results show that: (1) The shape of cumulative distribution curve of throat radius by mercury injection method is basically consistent with that of T2 relaxation time by NMR, and there is a good corresponding relationship between them. (2) The centrifugation process is similar to the gas displacing water process. With the decrease of water saturation, water centrifugation in rock core becomes more and more difficult until it become irreducible. (3) The core relative permeability curve obtained by the new method is consistent with the curve obtained by the standard method and has good repeatability. The new method can be used for gas-water relative permeability tests of low permeability tight sandstone. (4) The test process of the new method is unified and standard and up to 6 cores can be tested at the same time. The calculation results of water saturation and relative permeability curve are reliable and the integral curve is smooth, which greatly improves the test efficiency of gas-water relative permeability curve in lowpermeability and tight sandstone. The new method can be widely used to study the gas-water two-phase seepage law in low-permeability and tight sandstone gas reservoir.
Evaluation of knowledge, attitudes, and practices regarding the justification of radiological examinations among general practitioners in Morocco
Authors: Harbaj I. , Kharchaf Amina , mahjoub Chakir El , Harbaj Sara
Published: November 2024

This cross-sectional study aimed to evaluate Moroccan general practitioners' knowledge, attitudes, and practices regarding the justification of radiological exams and to identify the factors influencing these practices. A total of 367 general practitioners completed a 44-item questionnaire. Data analysis used independent t-tests, ANOVAs, Pearson correlations, and multiple regressions. The mean scores for knowledge, attitudes, and practices were 6.41 ± 1.36 out of 12, 3.79 ± 0.42 out of 5, and 3.38 ± 0.42 out of 5, respectively. Practice scores varied statistically significantly by gender (p = 0.004), age (p = 0.000), work experience (p = 0.000), workplace (p = 0.010), and training (p = 0.011). Unexpectedly, physicians who had not received radiation protection training outperformed those who had. There were significant positive correlations between scores for knowledge and attitudes (r = 0.566, p < 0.001), knowledge and practices (r = 0.547, p < 0.001), and attitudes and practices (r = 0.517, p < 0.001). The factors influencing justifying radiological examinations were knowledge, attitudes, gender, and age. The study revealed insufficient knowledge and practice despite a positive attitude towards the rationale for radiological examinations. These results underline the need to reevaluate and improve existing training programs. We recommend focusing on practical cases and real-life clinical scenarios while developing ongoing training and support tools tailored to the local context.
Konzept zur Evaluation der Patientenschulung
Osteoporose
Authors: Maus Uwe , Derichs Anna , Nolde Sophie , Niedhart Christopher
Published: November 2024

Das Disease Management Programm (DMP) Osteoporose wurde zum 01.07.2020 in Kraft
gesetzt und befindet sich aktuell in Umsetzung. In einigen KV-Bereichen ist das
DMP bereits umgesetzt. Eine Anforderung im Rahmen des DMP ist der Nachweis einer
evaluierten Patientenschule. Da die bisherigen Patientenschulungen diese
Anforderungen nicht vollständig erfüllen, wurde eine neue Patientenschulung
entworfen. Sie wird aktuell über Train-the-trainer-Programme an die
Leistungserbringer verbreitet und kann damit auch den Patientinnen und Patienten
angeboten werden. Parallel zu dieser Umsetzung ist die Evaluation der Schulung
geplant, um für das DMP vom Bundesamt für soziale Sicherung (BAS) dauerhaft
akzeptiert zu werden. Dafür sollen insgesamt 400 Patientinnen und Patienten,
aufgeteilt auf 2 Gruppen, eine strukturierte Schulung erhalten und der Effekt
der Schulung auf den Wissenszuwachs und körperliche Funktionstests erfasst
werden.
A Predictive Model Integrating AI Recognition Technology and Biomarkers for Lung Nodule Assessment
Authors: Zhou Tao , Zhu Ping , Xia Kaijian , Zhao Benying
Published: November 2024

Background Lung cancer is the most prevalent and lethal cancer globally, necessitating accurate differentiation between benign and malignant pulmonary nodules to guide treatment decisions. This study aims to develop a predictive model that integrates artificial intelligence (AI) analysis with biomarkers to enhance early detection and stratification of lung nodule malignancy.

Methods The study retrospectively analyzed the patients with pathologically confirmed pulmonary nodules. AI technology was employed to assess CT features, such as nodule size, solidity, and malignancy probability. Additionally, lung cancer blood biomarkers were measured. Statistical analysis involved univariate analysis to identify significant differences among factors, followed by multivariate logistic regression to establish independent risk factors. The model performance was validated using receiver operating characteristic curves and decision curve analysis (DCA) for internal validation. Furthermore, an external dataset comprising 51 cases of lung nodules was utilized for independent validation to assess robustness and generalizability.

Results A total of 176 patients were included, divided into benign/preinvasive (n = 76) and invasive cancer groups (n = 100). Multivariate analysis identified eight independent predictors of malignancy: lobulation sign, bronchial inflation sign, AI-predicted malignancy probability, nodule nature, diameter, solidity proportion, vascular endothelial growth factor, and lung cancer autoantibodies. The combined predictive model demonstrated high accuracy (area under the curve [AUC] = 0.946). DCA showed that the combined model significantly outperformed the traditional model, and also proved superior to models using AI-predicted malignancy probability or the seven lung cancer autoantibodies plus traditional model. External validation confirmed its robustness (AUC = 0.856), achieving a sensitivity of 0.80 and specificity of 0.86, effectively distinguishing between invasive and noninvasive nodules.

Conclusion This combined approach of AI-based CT features analysis with lung cancer biomarkers provides a more accurate and clinically useful tool for guiding treatment decisions in pulmonary nodule patients. Further studies with larger cohorts are warranted to validate these findings across diverse patient populations.
Safety and efficacy of lumen-apposing metal stents for endoscopic ultrasound-guided drainage of pancreatic fluid collections: a systematic review and meta-analysis
Authors: Suresh Kumar Vishnu Charan , Singh Sahib , Moond Vishali , Mohan Babu P. , Aswath Ganesh , Khan Hafiz M. A. , Sapkota Bishnu , Adler Douglas G.
Published: November 2024

Endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collections (PFCs) has variable outcomes according to the type of lumen-apposing metal stent (LAMS) used. We aimed to perform a systematic review and meta-analysis of the available data.

Online databases, including EMBASE, PubMed, and SCOPUS, were searched from inception to 30 January 2024. The outcomes of interest were technical success, clinical success, adverse events (AEs), and the need for endoscopic necrosectomy. Pooled estimates stratified by the type of stent (Axios, Nagi, or Spaxus), severity of bleeding, and type of PFC were calculated using a random-effects model. Heterogeneity was assessed by I
2 values.

37 studies were included in the final analysis. The pooled outcomes (95%CIs) for PFC drainage using the Axios, Nagi, and Spaxus stents, respectively, were: technical success 97.7% (96.4%–98.8%), 96.9% (94.6%–98.5%), 98.2% (94.4%–99.9%); clinical success 90.9% (88.7%–92.8%), 88.5% (79.9%–95.0%), 93.5% (91.0%–95.6%); total AEs 20.4% (16.6%–24.6%), 17.1% (8.3%–28.3%), 7.6% (3.6%–13.0); migration 4.2% (2.9%–5.7%), 7.8% (4.1%–12.4%), 0.9% (0.1%–2.8%); overall bleeding 7.0% (4.9%–9.5%), 4.4% (2.2%–7.4%), 1.8% (0.8%–3.3%); and endoscopic necrosectomy 54.5% (38.9%–69.7%), 16.0% (11.4%–21.3%), 19.9% (6.6%–38.1%). In terms of severity, moderate–severe bleeding was most common with all three stents. AEs were higher in patients with walled-off necrosis compared with pseudocysts. Substantial-to-considerable heterogeneity (I
2 >60%) was present for total AEs for all of the stents.

Our study shows good technical and clinical success rates with all three LAMSs for EUS-guided PFC drainage. Total AEs and bleeding were highest with the Axios stent and lowest with the Spaxus. Stent migration was highest with the Nagi stent and lowest with the Spaxus.
Abstracts of the Ninth Libyan Cardiac Society Congress, December 29–31, 2023, Benghazi, Libya
Authors: Elneihoum Ali , Benoor Anwaar , Elbarouni Basem , Abonowara Abdulghani , Mangoush Omar , Elkadiki Abdelhadi , Makraz Ibrahim , Zunni Mohamed , Smer Aiman
Published: November 2024

The 9th Annual Scientific Meeting of the Libyan Cardiac Society Congress (CARDIOLIBYA 2023) was held between December 29 and 31, 2023, in Tibesti Hotel in Benghazi, Libya. Abstracts were received in three categories: clinical vignette, research, and quality improvement. All abstracts underwent a peer-review process by the scientific committee and independent reviewers. A grading system was used based on the abstract’s quality, novelty, and clinical significance. Here, we present both the oral and poster abstracts as submitted by the authors after minimal restyling to suit publication purposes. They are published here for rapid communication and to benefit those who could not attend the congress physically.
Innominate Artery Translocation with Hemiarch Replacement Strategy for Acute Type A Aortic Dissection: a Single-Center Study
Authors: Phothikun Amarit , Kanokkavinvong Nutthayuth , Nawarawong Weerachai , Taksaudom Noppon , Woragidpoonpol Surin
Published: November 2024

Background Aggressive surgical methods for acute type A aortic dissection (ATAD) can cause extended operating times and postoperative complications. less extensive techniques may increase the risk of needing further aortic reintervention. To prevent the need for extensive aortic arch surgery and subsequent re-sternotomy, hemiarch replacement (HAR) with innominate artery (a.) translocation is performed to create a suitable proximal landing zone for future endovascular repair.

Methods Retrospective study of 112 patients with ATAD who underwent aortic surgery from January 2009 to December 2020. Forty-one patients underwent HAR with innominate artery translocation, 16 underwent total arch replacement (TAR), and 55 underwent only HAR. Multivariable Cox regression and logistic regression analyses were used to study the outcomes and risk factors.

Results The TAR group had a higher incidence of postoperative acute kidney injury. The overall mortality rate of the TAR group was 25%, compared with 20% in the HAR group and 14.6% in the translocation group. The 5-year overall survival rates for the groups were 81.9%, 75.0%, and 77.7%, respectively. False lumen thrombosis at the aortic arch and descending aorta level were factors associated with reduced mortality in both univariable and multivariable analyses. The translocation group had a significantly higher reintervention rate of 41.5% compared with the TAR and HAR groups, with rates of 31.3% and 16.4%, respectively. The median reintervention time for the translocation group was 4.72 years.

Conclusion Despite the innominate translocation technique having a higher reintervention rate, it had similar mortality outcomes to HAR and TAR. Thus, it could be a more convenient option for reintervention, including creating a proximal landing zone, which could benefit patients needing endovascular repair.
Chronic Mesenteric Ischemia after a Type A Aortic Dissection Repair
Authors: Hardman Morgan , Farres Houssam , Lanka Santh Prakash , Erben Young
Published: November 2024

A 57-year-old male patient who underwent an open hemiarch repair with a femoral–femoral crossover bypass and right lower extremity fasciotomies for an acute Type A aortic dissection with limb ischemia presented 5 weeks' postrepair with a 20-pound weight loss due to intermittent hemodynamic collapse of the dissection flap over the origin of the superior mesenteric artery. This case highlights the challenges a dissection flap can cause after an urgent Type A aortic dissection repair.
Beyond dissonance: the transformative power of thought analysis in philosophical practice
Authors: Ding Xiaojun , Xie Caifeng , Yu Feng
Published: November 2024

This paper provides a comprehensive examination of thought analysis as a contemporary practice within philosophical inquiry, exploring its theoretical foundations, methodological approaches, and practical implications. Rooted in classical philosophical traditions yet acutely relevant to modern life, thought analysis—officially conceptualized by Tianqun Pan—serves as a bridge between knowledge and action, addressing the cognitive dissonance that often hinders personal growth and rational decision-making. Through an analysis of historical and recent sources, including case studies from the laboratory of thought analysis at Nanjing University, we investigate whether logical reasoning is an innate human capacity or developed through education and practice, highlighting the importance of fostering logical skills in thought analysis. Ethical considerations, such as trust between analyst and visitor and the principle of value neutrality, are critically examined to underscore the necessity of maintaining visitor autonomy and preventing bias. We explore the relationship between thought analysis and therapeutic practices, emphasizing that while thought analysis is not inherently therapeutic, it possesses qualities that can lead to psychological relief and personal development through the clarification of thought. Comparative analyses with Logic-based Therapy and Logotherapy illustrate the unique position of thought analysis within philosophical practice. By reframing thought analysis as a form of humanistic care rather than clinical therapy, the paper advocates for its role in promoting clear thinking, self-awareness, and ethical living, thereby contributing to individual well-being and social harmony. Ultimately, the study affirms thought analysis as a transformative practice that aligns philosophical inquiry with practical life, empowering individuals to achieve greater coherence between their beliefs and actions.
Ultrasound velocity and intermolecular interactions in liquid hydrogen
Authors: Pashkov V. V. , Marinin V. S. , Konovodchenko E. V.
Published: November 2024

Experiments have been conducted to determine the dependence of the ultrasound propagation velocity in liquid hydrogen on the thermodynamic parameters and the ortho–para mixture. The results are used to find the difference in the ultrasound velocity in normal and para hydrogen. The experimental data are analyzed using a theoretical model which takes into account the important role of the quantum effects and the anisotropy of molecular interactions in ortho-para hydrogen mixtures.
Matrix product state ansatz for the variational quantum solution of the Heisenberg model on Kagome geometries
Authors: Javanmard Younes , Liaubaite Ugne , Osborne Tobias J. , Xu Xusheng , Yung Man-Hong
Published: November 2024

The Variational Quantum Eigensolver (VQE) algorithm, as applied to finding the ground state of a Hamiltonian, is particularly well-suited for deployment on noisy intermediate-scale quantum (NISQ) devices. Here, we utilize the VQE algorithm with a quantum circuit ansatz inspired by the Density Matrix Renormalization Group (DMRG) algorithm. To ameliorate the impact of realistic noise on the performance of the method, we employ zero-noise extrapolation. We find that, with realistic error rates, our DMRG–VQE hybrid algorithm delivers good results for strongly correlated systems. We illustrate our approach with the Heisenberg model on a Kagome lattice patch and demonstrate that DMRG–VQE hybrid methods can locate and faithfully represent the physics of the ground state of such systems. Moreover, the parameterized ansatz circuit used in this work is low depth and requires a reasonably small number of parameters, so it is efficient for NISQ devices.
Applications of machine learning to high temperature and high pressure environments: A literature review
Authors: Wang Hengkai , Lv Zengtao , Kumar Santosh , Wang Qinglin
Published: November 2024

In recent years, machine learning as a new style of calculation has been developed quickly, and because it can obtain results that experiments cannot achieve, it has become a useful calculation tool in the field of high temperature and high pressure (HTHP). It can simulate and calculate the experimental results according to some calculation principles, such as first-principles, and execute prediction based on models created, such as Gaussian approximation potential, to obtain high-precision results. In addition, its simulation process is very fast, and the cost is not as expensive as that of density functional theory, so machine learning in the field of HTHP computing has aroused great research interest. The rapid development of machine learning makes it a powerful tool to predict some parameter or mechanism of materials and brings a new chance to simulate more complex experimental environments. In this paper, we review some of the most recent applications and insights into machine learning techniques in the fields of mechanics, thermology, electricity, and structural search under the demanding conditions of HTHP.
Influence of Janus structure on the thermoelectric performance of the α-Se monolayer
Authors: Liu Q. H. , Shi H. L. , Han Q. Z. , Yang J. , Zhao Y. H. , Gong L. J. , Yang H. , Cheng R. S. , Jiang Z. T.
Published: November 2024

Aiming at exploring whether the Janus structure is beneficial to improving the thermoelectric (TE) performance, we systematically study the TE properties of the α-Se-monolayer-based Janus structures including α-SSe2 and α-TeSe2 monolayers. In comparison with the semiconducting α-Se monolayer, the Janus α-SSe2 and α-TeSe2 monolayers are still kept to be indirect semiconductors but with suppressed energy bandgaps. Moreover, the phononic thermal conductance will be suppressed with other parameters like Seebeck coefficients, electrical conductances, and electronic thermal conductances being changed correspondingly. The TE figures of merit ZTs of the Janus α-SSe2 and α-TeSe2 monolayers are always greater than that of the α-Se monolayer, indicating that the Janus structure should be a potential scheme used to improve the TE performance of materials.
Dissecting neurofilament tail sequence-phosphorylation-structure relationships with multicomponent reconstituted protein brushes
Authors: Ding Erika A. , Yokokura Takashi J. , Wang Rui , Kumar Sanjay
Published: November 2024

Neurofilaments (NFs) are multisubunit, bottlebrush-shaped intermediate filaments abundant in the axonal cytoskeleton. Each NF subunit contains a long intrinsically disordered tail domain, which protrudes from the NF core to form a “brush” surrounding each NF. Precisely how the tails’ variable charge patterns and repetitive phosphorylation sites mediate their conformation within the brush remains an open question in axonal biology. We address this problem by grafting recombinant NF tail protein constructs NF-Light, -Medium, and -Heavy (NFL, NFM, and NFH) to surfaces, yielding protein brushes of defined stoichiometry that can be phosphorylated in vitro. Atomic force microscopy measurements reveal that brush height depends on composition monotonically but not always linearly for binary NFL:NFM or NFL:NFH systems, and that NFM-based brushes are highly extended, while brushes incorporating the much larger NFH are surprisingly compact even after multisite phosphorylation. Complementary self-consistent field theory (SCFT) predicts multilayer brush morphologies for NFM and phosphorylated NFH brushes. Further experiments and SCFT analysis with designed mutants reveal that N-terminal negative charges in the NFH tail repel phosphorylated residues to generate the multilayer morphology, while the C-terminal charge-neutral region contributes to multilayer brush morphology but not total brush height. Charge-shuffled NFM variants show that charge segregation promotes brush collapse near physiological ionic strengths. Collectively, this study supports a role for NFM in establishing a dynamic range for NF brush conformation, lending insight into previous in vitro and in vivo findings. More broadly, this work establishes a platform for dissecting contributions of disordered protein sequence to conformation at interfaces.
Slavery, sentimentality and the abolition of affect
Authors: Festa Lynn
Published: November 2024

This essay addresses the way details about the unspeakable conditions on the slave ships interrupt
the sentimentalization of the plight of the enslaved in order to examine the political volatility of affect — in
particular, disgust — in the late eighteenth-century metropolitan debates over the abolition of the slave trade. While
disgust, with its capacity to assign abject qualities to objects, would seem to be the province of the proslavery
advocates seeking to strip the enslaved of their claim to humanity, this volatile affect also plays a role in
abolitionist efforts to convert visceral responses to descriptions of the Middle Passage into an impetus for action,
making dehumanizing revulsion into moral outrage.
Touching difference and colonial space
Authors: Birkeli Helene Engnes
Published: November 2024

This essay argues that Little Marie on Neky’s Arm (1838), a portrait by the Danish
painter Niels P. Holbech, provides a challenge to sentimental constructions of the West-Indian “nanny” figure. The
relational ambiguity of this painting recalls that of the wet nurse and her charge, a figure of nineteenth-century
French painting described by Linda Nochlin (1988). In the context of the
colonial imaginary, the nanny figure represented fears of “miscegenation” while also acting as a foil to white
European motherhood. Other Danish painters portrayed the nanny figure against the backdrop of the external world.
Holbech, however, foregrounds Neky and her charge, Marie by locating them in an indeterminate space. Through its close
attention to detail and difference, the painting lays bare the colonial ideology demarcating near and far, nation and
colony.
Politics and faith, slavery and abolition in nineteenth-century Brazilian literature
Authors: Collins Jane-Marie
Published: November 2024

The first Brazilian abolitionist novel, Úrsula (1859), was written by a black
woman, Maria Firmina dos Reis (1825–1917). Reis’s entire literary production was lost for over a century and discovery
and recovery commenced only in the 1960s. This chapter examines Úrsula, and Reis’s short story
A escrava [The slave woman] (1887). Úrsula was written in the decade following
the abolition of the trans-Atlantic slave trade to Brazil in 1850, while A escrava was written on the
brink of the abolition of slavery (1888) and the fall of the monarchy (1889). The analysis presented here locates
Reis’s writing within the history and historiography of slavery and abolition in nineteenth-century Brazil.
Intellectually, this study also examines Reis's two texts through conventions of sentimental and Romantic writing,
allowing a discursive and historical disentangling of her literary treatment of slavery and abolition. Culturally, it
is argued that Reis's religious belief, as a Roman Catholic, was critical to her writing in ways that have been
overlooked in the scholarship to date. Finally, it is proposed that as a descendant of enslaved Africans herself,
Reis's anti-slavery writing belongs to the wider corpus of black women's writing across the Americas.