bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis
Authors: Boles Usama , Johansson Anders , Wiklund Urban , Sharif Zain , David Santhosh , McGrory Siobhan , Henein Michael
Published: January 2018

Background: Coronary artery ectasia (CAE) is a rare disorder commonly associated with additional features of atherosclerosis. In the present study, we aimed to examine the systemic immune-inflammatory response that might associate CAE. Methods: Plasma samples were obtained from 16 patients with coronary artery ectasia (mean age 64.9 ± 7.3 years, 6 female), 69 patients with coronary artery disease (CAD) and angiographic evidence for atherosclerosis (age 64.5 ± 8.7 years, 41 female), and 140 controls (mean age 58.6 ± 4.1 years, 40 female) with normal coronary arteries. Samples were analyzed at Umeå University Biochemistry Laboratory, Sweden, using the V-PLEX Pro-Inflammatory Panel 1 (human) Kit. Statistically significant differences (p < 0.05) between patient groups and controls were determined using Mann–Whitney U-tests. Results: The CAE patients had significantly higher plasma levels of INF-γ, TNF-α, IL-1β, and IL-8 (p = 0.007, 0.01, 0.001, and 0.002, respectively), and lower levels of IL-2 and IL-4 (p < 0.001 for both) compared to CAD patients and controls. The plasma levels of IL-10, IL-12p, and IL-13 were not different between the three groups. None of these markers could differentiate between patients with pure (n = 6) and mixed with minimal atherosclerosis (n = 10) CAE. Conclusions: These results indicate an enhanced systemic pro-inflammatory response in CAE. The profile of this response indicates activation of macrophages through a pathway and trigger different from those of atherosclerosis immune inflammatory response.
Caffeic Acid and Metformin Inhibit Invasive Phenotype Induced by TGF-β1 in C-4I and HTB-35/SiHa Human Cervical Squamous Carcinoma Cells by Acting on Different Molecular Targets
Authors: Tyszka-Czochara Malgorzata , Lasota Malgorzata , Majka Marcin
Published: January 2018

During the progression of epithelial cancer, the cells may lose epithelial markers and gain mesenchymal phenotype via Epithelial-Mesenchymal Transition (EMT). Such transformation of epithelial cancer cells to mesenchymal-like characteristic benefits plasticity and supports their ability to migrate. The aim of this study was to evaluate the influence of natural compound Caffeic Acid (CA) alone and in combination with antidiabetic drug Metformin (Met) on metastatic progression of two human cervical squamous cell cancer lines, C-4I and HTB-35/SiHa cells. EMT program was triggered by exposition of both epithelial cell lines to TGF-β1. Gene expression patterns related to epithelial/mesenchymal phenotype were evaluated by Real-Time PCR analysis and the protein amount was detected by western blot. The treatment of human squamous cancer cells with CA and with Met, suppressed the motility of cells and the effect depended on a particular cell line. Both compounds regulated the EMT process in C4-I and HTB-35 cells by interfering with different molecular targets. In TGF-β1-stimulated C4-I cells, CA suppressed the expression of mesenchymal transcription factor SNAI1 which resulted in enhanced expression of epithelial markers E-cadherin, Occludin and Claudin. Additionally, CA blocked MMP-9 and upregulated TIMP-1 expression, a specific inhibitor of MMP-9. In HTB-35 cells stimulated with TGF-β1, Met decreased the expression of Vimentin. By suppressing hypoxia master regulator HIF-1α, Met caused downregulation of CAIX, an enzyme involved in metastasis of aggressive malignant cells. In this study we showed that CA and Met inhibited EMT process in cancer cells via different mechanisms. However, when applied together, compounds exerted the greater effect on EMT than each compound alone. This is the first report revealing that CA alone and co-treated with Met may reverse mesenchymal phenotype of TGF-β1-treated cervical tumor cells and we believe that the use of the two small molecules may be considered as a potential therapeutic approach for metastatic cervical cancer.
Soybean-Derived Phytoalexins Improve Cognitive Function through Activation of Nrf2/HO-1 Signaling Pathway
Authors: Seo Ji , Kim Bo , Oh Jisun , Kim Jong-Sang
Published: January 2018

As soy-derived glyceollins are known to induce antioxidant enzymes in various types of cells and tissues, we hypothesized that the compounds could protect neurons from damage due to reactive oxygen species (ROS). In order to examine the neuroprotective effect of glyceollins, primary cortical neurons collected from mice and mouse hippocampal HT22 cells were challenged with glutamate. Glyceollins attenuated glutamate-induced cytotoxicity in primary cortical neuron isolated from mice carrying wild-type nuclear factor (erythroid-derived 2)-like 2 (Nrf2), but the compounds were ineffective in those isolated from Nrf2 knockout mice, suggesting the involvement of the Nrf2 signaling pathway in glyceollin-mediated neuroprotection. Furthermore, the inhibition of heme oxygenase-1 (HO-1), a major downstream enzyme of Nrf2, abolished the suppressive effect of glyceollins against glutamate-induced ROS production and cytotoxicity, confirming that activation of HO-1 by glyceollins is responsible for the neuroprotection. To examine whether glyceollins also improve cognitive ability, mice pretreated with glyceollins were challenged with scopolamine and subjected to behavioral tests. Glyceollins attenuated scopolamine-induced cognitive impairment of mice, but failed to enhance memory in Nrf2 knockout mice, suggesting that the memory-enhancing effect is also mediated by the Nrf2 signaling pathway. Overall, glyceollins showed neuroprotection against glutamate-induced damage, and attenuated scopolamine-induced memory deficits in an Nrf2-dependent manner.
Cytotoxicity Evaluation of Turmeric Extract Incorporated Oil-in-Water Nanoemulsion
Authors: Yoon Hee , Zhang Xiaowei , Kang Min , Kim Gyeong , Shin Sun , Baek Sang , Lee Bom , Hong Su , Kim Jun , Hong Kwonho , Bae Hojae
Published: January 2018

To overcome the drawbacks of conventional drug delivery system, nanoemulsion have been developed as an advanced form for improving the delivery of active ingredients. However, safety evaluation is crucial during the development stage before the commercialization. Therefore, the aim of this study was to evaluate the cytotoxicity of two types of newly developed nanoemulsions. Turmeric extract-loaded nanoemulsion powder-10.6 (TE-NEP-10.6, high content of artificial surfactant Tween 80), which forms the optimal nanoemulsion, and the TE-NEP-8.6 made by increasing the content of natural emulsifier (lecithin) to reduce the potential toxicity of nanoemulsion were cultured with various cells (NIH3T3, H9C2, HepG2, hCPC, and hEPC) and the changes of each cell were observed followed by nanoemulsion treatment. As a result, the two nanoemulsions (TE-NEP-10.6 and TE-NEP-8.6) did not show significant difference in cell viability. In the case of cell line (NIH3T3, H9C2, and HepG2), toxicity was not observed at an experimental concentration of less than 1 mg/mL, however, the cell survival rate decreased in a concentration dependent manner in the case of primary cultured cells. These results from our study can be used as a basic data to confirm the cell type dependent toxicity of nanoemulsion.
Early Detection and Diagnosis of Neonatal Intrahepatic Cholestasis Caused by Citrin Deficiency Missed by Newborn Screening Using Tandem Mass Spectrometry
Authors: Shigetomi Hiroko , Tanaka Toju , Nagao Masayoshi , Tsutsumi Hiroyuki
Published: January 2018

Citrullinemia is the earliest identifiable biochemical abnormality in neonates with intrahepatic cholestasis due to a citrin deficiency (NICCD) and it has been included in newborn screening panels using tandem mass spectrometry. However, only one neonate was positive among 600,000 infants born in Sapporo city and Hokkaido, Japan between 2006 and 2017. We investigated 12 neonates with NICCD who were initially considered normal in newborn mass screening (NBS) by tandem mass spectrometry, but were later diagnosed with NICCD by DNA tests. Using their initial NBS data, we examined citrulline concentrations and ratios of citrulline to total amino acids. Although their citrulline values exceeded the mean of the normal neonates and 80% of them surpassed +3 SD (standard deviation), all were below the cutoff of 40 nmol/mL. The ratios of citrulline to total amino acids significantly elevated in patients with NICCD compared to the control. By evaluating two indicators simultaneously, we could select about 80% of patients with missed NICCD. Introducing an estimated index comprising citrulline values and citrulline to total amino acid ratios could assure NICCD detection by NBS.
Ambient Assisted Living for Improvement of Health and Quality of Life—A Special Issue of the Journal of Informatics
Authors: Zhang Shuai , Nugent Chris , Lundström Jens , Sheng Min
Published: January 2018

The demographic change with respect to the ageing of the population has been a worldwide trend[...]
High-Temperature Raman Spectroscopy of Nano-Crystalline Carbon in Silicon Oxycarbide
Authors: Rosenburg Felix , Ionescu Emanuel , Nicoloso Norbert , Riedel Ralf
Published: January 2018

The microstructure of segregated carbon in silicon oxycarbide (SiOC), hot-pressed at T = 1600 °C and p = 50 MPa, has been investigated by VIS Raman spectroscopy (λ = 514 nm) within the temperature range 25–1000 °C in air. The occurrence of the G, D’ and D bands at 1590, 1620 and 1350 cm−1, together with a lateral crystal size La < 10 nm and an average distance between lattice defects LD ≈ 8 nm, provides evidence that carbon exists as nano-crystalline phase in SiOC containing 11 and 17 vol % carbon. Both samples show a linear red shift of the G band up to the highest temperature applied, which is in agreement with the description of the anharmonic contribution to the lattice potential by the modified Tersoff potential. The temperature coefficient χG = −0.024 ± 0.001 cm−1/°C is close to that of disordered carbon, e.g., carbon nanowalls or commercial activated graphite. The line width of the G band is independent of temperature with FWHM-values of 35 cm−1 (C-11) and 45 cm−1 (C-17), suggesting that scattering with defects and impurities outweighs the phonon-phonon and phonon-electron interactions. Analysis of the Raman line intensities indicates vacancies as dominating defects.
The Use of Municipal Solid Waste Incineration Ash in Various Building Materials: A Belgian Point of View
Authors: Joseph Aneeta , Snellings Ruben , Van den Heede Philip , Matthys Stijn , De Belie Nele
Published: January 2018

Huge amounts of waste are being generated, and even though the incineration process reduces the mass and volume of waste to a large extent, massive amounts of residues still remain. On average, out of 1.3 billion tons of municipal solid wastes generated per year, around 130 and 2.1 million tons are incinerated in the world and in Belgium, respectively. Around 400 kT of bottom ash residues are generated in Flanders, out of which only 102 kT are utilized here, and the rest is exported or landfilled due to non-conformity to environmental regulations. Landfilling makes the valuable resources in the residues unavailable and results in more primary raw materials being used, increasing mining and related hazards. Identifying and employing the right pre-treatment technique for the highest value application is the key to attaining a circular economy. We reviewed the present pre-treatment and utilization scenarios in Belgium, and the advancements in research around the world for realization of maximum utilization are reported in this paper. Uses of the material in the cement industry as a binder and cement raw meal replacement are identified as possible effective utilization options for large quantities of bottom ash. Pre-treatment techniques that could facilitate this use are also discussed. With all the research evidence available, there is now a need for combined efforts from incineration and the cement industry for technical and economic optimization of the process flow.
Real Time Spectroscopic Ellipsometry Analysis of First Stage CuIn1−xGaxSe2 Growth: Indium-Gallium Selenide Co-Evaporation
Authors: Pradhan Puja , Aryal Puruswottam , Attygalle Dinesh , Ibdah Abdel-Rahman , Koirala Prakash , Li Jian , Bhandari Khagendra , Liyanage Geethika , Ellingson Randy , Heben Michael , Marsillac Sylvain , Collins Robert , Podraza Nikolas
Published: January 2018

Real time spectroscopic ellipsometry (RTSE) has been applied for in-situ monitoring of the first stage of copper indium-gallium diselenide (CIGS) thin film deposition by the three-stage co-evaporation process used for fabrication of high efficiency thin film photovoltaic (PV) devices. The first stage entails the growth of indium-gallium selenide (In1−xGax)2Se3 (IGS) on a substrate of Mo-coated soda lime glass maintained at a temperature of 400 °C. This is a critical stage of CIGS deposition because a large fraction of the final film thickness is deposited, and as a result precise compositional control is desired in order to achieve the optimum performance of the resulting CIGS solar cell. RTSE is sensitive to monolayer level film growth processes and can provide accurate measurements of bulk and surface roughness layer thicknesses. These in turn enable accurate measurements of the bulk layer optical response in the form of the complex dielectric function ε = ε1 − iε2, spectra. Here, RTSE has been used to obtain the (ε1, ε2) spectra at the measurement temperature of 400 °C for IGS thin films of different Ga contents (x) deduced from different ranges of accumulated bulk layer thickness during the deposition process. Applying an analytical expression in common for each of the (ε1, ε2) spectra of these IGS films, oscillator parameters have been obtained in the best fits and these parameters in turn have been fitted with polynomials in x. From the resulting database of polynomial coefficients, the (ε1, ε2) spectra can be generated for any composition of IGS from the single parameter, x. The results have served as an RTSE fingerprint for IGS composition and have provided further structural information beyond simply thicknesses, for example information related to film density and grain size. The deduced IGS structural evolution and the (ε1, ε2) spectra have been interpreted as well in relation to observations from scanning electron microscopy, X-ray diffractometry and energy-dispersive X-ray spectroscopy profiling analyses. Overall the structural, optical and compositional analysis possible by RTSE has assisted in understanding the growth and properties of three stage CIGS absorbers for solar cells and shows future promise for enhancing cell performance through monitoring and control.
Spin Absorption Effect at Ferromagnet/Ge Schottky-Tunnel Contacts
Authors: Yamada Michihiro , Fujita Yuichi , Yamada Shinya , Sawano Kentarou , Hamaya Kohei
Published: January 2018

We study the influence of the junction size in ferromagnet (FM)/semiconductor (SC) contacts on four-terminal nonlocal spin signals in SC-based lateral spin-valve (LSV) structures. When we use FM/Ge Schottky-tunnel junctions with relatively low resistance-area products, the magnitude of the nonlocal spin signal depends clearly on the junction size, indicating the presence of the spin absorption effect at the spin-injector contact. The temperature-dependent spin signal can also be affected by the spin absorption effect. For SC spintronic applications with a low parasitic resistance, we should consider the influence of the spin absorption on the spin-transport signals in SC-based device structures.
Synthesis and Characterization of a Heterometallic Extended Architecture Based on a Manganese(II)-Substituted Sandwich-Type Polyoxotungstate
Authors: Ibrahim Masooma , Moreno-Pineda Eufemio , Bergfeldt Thomas , Anson Christopher , Powell Annie
Published: January 2018

The reaction of [α-P2W15O56]12− with MnII and DyIII in an aqueous basic solution led to the isolation of an all inorganic heterometallic aggregate Na10(OH2)42[{Dy(H2O)6}2Mn4P4W30O112(H2O)2]·17H2O (Dy2Mn4-P2W15). Single-crystal X-ray diffraction revealed that Dy2Mn4-P2W15 crystallizes in the triclinic system with space group P 1 ¯ , and consists of a tetranuclear manganese(II)-substituted sandwich-type phosphotungstate [Mn4(H2O)2(P2W15O56)2]16− (Mn4-P2W15), Na, and DyIII cations. Compound Dy2Mn4-P2W15 exhibits a 1D ladder-like chain structure based on sandwich-type segments and dysprosium cations as linkers, which are further connected into a three-dimensional open framework by sodium cations. The title compound was structurally and compositionally characterized in solid state by single-crystal XRD, powder X-ray diffraction (PXRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric (TGA), and elemental analyses. Further, the absorption and emission electronic spectra in aqueous solutions of Dy2Mn4-P2W15 and Mn4-P2W15 were studied. Also, magnetic properties were studied and compared with the magnetic behavior of [Mn4(H2O)2(P2W15O56)2]16−.
Structure Elucidation of Unknown Metabolites in Metabolomics by Combined NMR and MS/MS Prediction
Authors: Boiteau Rene , Hoyt David , Nicora Carrie , Kinmonth-Schultz Hannah , Ward Joy , Bingol Kerem
Published: January 2018

We introduce a cheminformatics approach that combines highly selective and orthogonal structure elucidation parameters; accurate mass, MS/MS (MS2), and NMR into a single analysis platform to accurately identify unknown metabolites in untargeted studies. The approach starts with an unknown LC-MS feature, and then combines the experimental MS/MS and NMR information of the unknown to effectively filter out the false positive candidate structures based on their predicted MS/MS and NMR spectra. We demonstrate the approach on a model mixture, and then we identify an uncatalogued secondary metabolite in Arabidopsis thaliana. The NMR/MS2 approach is well suited to the discovery of new metabolites in plant extracts, microbes, soils, dissolved organic matter, food extracts, biofuels, and biomedical samples, facilitating the identification of metabolites that are not present in experimental NMR and MS metabolomics databases.
Design Considerations for a Sub-mW Wireless Medical Body-Area Network Receiver Front End
Authors: Kargaran Ehsan , Manstretta Danilo , Castello Rinaldo
Published: January 2018

Wireless medical body-area networks are used to connect sensor nodes that monitor vital parameters. The radio consumes a large portion of the sensor energy budget, and hence its power dissipation should be minimized. The low-noise amplifier (LNA) is an important component of the receiver, and must guarantee low-noise amplification and impedance matching. In this work, an ultra-low-voltage ultra-low-power LNA is proposed that, thanks to the proposed transformer-based gate boosting technique, has a reduced current consumption of only 160 μA and can operate with a supply as low as 0.18 V. The LNA was designed using 40 nm Complementary Metal-Oxide Semiconductor (CMOS) technology and features a voltage gain of 14 dB, 5.2 dB NF and −8.6 dBm IIP3. This performance is comparable to a prior work by the same authors, but with the minimum supply voltage reduced by a factor of 4x.
Synthesis of Novel Reactive Disperse Silicon-Containing Dyes and Their Coloring Properties on Silicone Rubbers
Authors: Yu Ning , Zhang Shufen , Tang Bingtao , Ma Wei , Qiu Jinjing
Published: January 2018

Novel red and purple reactive disperse silicon-containing dyes were designed and synthesized using p-nitroaniline and 6-bromo-2,4-dinitro-aniline as diazonium components, the first condensation product of cyanuric chloride and 3-(N,N-diethyl)amino-aniline as coupling component, and 3-aminopropylmethoxydimethylsilane, 3-aminopropylmethyldimethoxysilane, and 3-aminopropyltrimethoxysilane as silicone reactive agents. These dyes were characterized by UV-Vis, 1H-NMR, FT-IR, and MS. The obtained reactive disperse silicon-containing dyes were used to color silicone rubbers and the color fastness of the dyes were evaluated. The dry/wet rubbing and washing fastnesses of these dyes all reached 4–5 grade and the sublimation fastness was also above 4 grade, indicating outstanding performance in terms of color fastness. Such colored silicone rubbers showed bright and rich colors without affecting its static mechanical properties.
Reference Gene Selection for Quantitative Real-Time Reverse-Transcriptase PCR in Annual Ryegrass (Lolium multiflorum) Subjected to Various Abiotic Stresses
Authors: Liu Qiuxu , Qi Xiao , Yan Haidong , Huang Linkai , Nie Gang , Zhang Xinquan
Published: January 2018

To select the most stable reference genes in annual ryegrass (Lolium multiflorum), we studied annual ryegrass leaf tissues exposed to various abiotic stresses by qRT-PCR and selected 11 candidate reference genes, i.e., 18S rRNA, E2, GAPDH, eIF4A, HIS3, SAMDC, TBP-1, Unigene71, Unigene77, Unigene755, and Unigene14912. We then used GeNorm, NormFinder, and BestKeeper to analyze the expression stability of these 11 genes, and used RefFinder to comprehensively rank genes according to stability. Under different stress conditions, the most suitable reference genes for studies of leaf tissues of annual ryegrass were different. The expression of the eIF4A gene was the most stable under drought stress. Under saline-alkali stress, Unigene14912 has the highest expression stability. Under acidic aluminum stress, SAMDC expression stability was highest. Under heavy metal stress, Unigene71 expression had the highest stability. According to the software analyses, Unigene14912, HIS3, and eIF4A were the most suitable for analyses of abiotic stress in tissues of annual ryegrass. GAPDH was the least suitable reference gene. In conclusion, selecting appropriate reference genes under abiotic stress not only improves the accuracy of annual ryegrass gene expression analyses, but also provides a theoretical reference for the development of reference genes in plants of the genus Lolium.
Mechano-Enzymatic Deconstruction with a New Enzymatic Cocktail to Enhance Enzymatic Hydrolysis and Bioethanol Fermentation of Two Macroalgae Species
Authors: Amamou Sameh , Sambusiti Cecilia , Monlau Florian , Dubreucq Eric , Barakat Abdellatif
Published: January 2018

The aim of this study was to explore the efficiency of a mechano-enzymatic deconstruction of two macroalgae species for sugars and bioethanol production, by using a new enzymatic cocktail (Haliatase) and two types of milling modes (vibro-ball: VBM and centrifugal milling: CM). By increasing the enzymatic concentration from 3.4 to 30 g/L, the total sugars released after 72 h of hydrolysis increased (from 6.7 to 13.1 g/100 g TS and from 7.95 to 10.8 g/100 g TS for the green algae U. lactuca and the red algae G. sesquipedale, respectively). Conversely, total sugars released from G. sesquipedale increased (up to 126% and 129% after VBM and CM, respectively). The best bioethanol yield (6 geth/100 g TS) was reached after 72 h of fermentation of U. lactuca and no increase was obtained after centrifugal milling. The latter led to an enhancement of the ethanol yield of G. sesquipedale (from 2 to 4 g/100 g TS).
Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases
Authors: Ghashghaei Ouldouz , Kielland Nicola , Revés Marc , Taylor Martin , Kelly John , Di Pietro Ornella , Muñoz-Torrero Diego , Pérez Belén , Lavilla Rodolfo
Published: January 2018

Imidazolium salts are privileged compounds in organic chemistry, and have valuable biological properties. Recent studies show that symmetric imidazolium salts with bulky moieties can display antiparasitic activity against T. cruzi. After developing a facile methodology for the synthesis of tetrasubstituted imidazolium salts from propargylamines and isocyanides, we screened a small library of these adducts against the causative agents of African and American trypanosomiases. These compounds display nanomolar activity against T. brucei and low (or sub) micromolar activity against T. cruzi, with excellent selectivity indexes and favorable molecular properties, thereby emerging as promising hits for the treatment of Chagas disease and sleeping sickness.
Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus
Authors: Huijbers Mieke , Van Alen Ilona , Wu Jenny , Barendregt Arjan , Heck Albert , Van Berkel Willem
Published: January 2018

Proline dehydrogenase (ProDH) is a ubiquitous flavoenzyme that catalyzes the oxidation of proline to Δ1-pyrroline-5-carboxylate. Thermus thermophilus ProDH (TtProDH) contains in addition to its flavin-binding domain an N-terminal arm, consisting of helices αA, αB, and αC. Here, we report the biochemical properties of the helical arm truncated TtProDH variants ΔA, ΔAB, and ΔABC, produced with maltose-binding protein as solubility tag. All three truncated variants show similar spectral properties as TtProDH, indicative of a conserved flavin-binding pocket. ΔA and ΔAB are highly active tetramers that rapidly react with the suicide inhibitor N-propargylglycine. Removal of the entire N-terminal arm (ΔABC) results in barely active dimers that are incapable of forming a flavin adduct with N-propargylglycine. Characterization of V32D, Y35F, and V36D variants of ΔAB established that a hydrophobic patch between helix αC and helix α8 is critical for TtProDH catalysis and tetramer stabilization.
Nanopatterning via Self-Assembly of a Lamellar-Forming Polystyrene-block-Poly(dimethylsiloxane) Diblock Copolymer on Topographical Substrates Fabricated by Nanoimprint Lithography
Authors: Borah Dipu , Cummins Cian , Rasappa Sozaraj , Senthamaraikannan Ramsankar , Salaun Mathieu , Zelsmann Marc , Liontos George , Ntetsikas Konstantinos , Avgeropoulos Apostolos , Morris Michael
Published: January 2018

The self-assembly of a lamellar-forming polystyrene-block-poly(dimethylsiloxane) (PS-b-PDMS) diblock copolymer (DBCP) was studied herein for surface nanopatterning. The DBCP was synthesized by sequential living anionic polymerization of styrene and hexamethylcyclotrisiloxane (D3). The number average molecular weight (Mn), polydispersity index (Mw/Mn) and PS volume fraction (φps) of the DBCP were MnPS = 23.0 kg mol−1, MnPDMS = 15.0 kg mol−1, Mw/Mn = 1.06 and φps = 0.6. Thin films of the DBCP were cast and solvent annealed on topographically patterned polyhedral oligomeric silsesquioxane (POSS) substrates. The lamellae repeat distance or pitch (λL) and the width of the PDMS features (dL) are ~35 nm and ~17 nm, respectively, as determined by SEM. The chemistry of the POSS substrates was tuned, and the effects on the self-assembly of the DBCP noted. The PDMS nanopatterns were used as etching mask in order to transfer the DBCP pattern to underlying silicon substrate by a complex plasma etch process yielding sub-15 nm silicon features.
Long-Term Mechanical Behavior of Nano Silica Sol Grouting
Authors: Pan Dongjiang , Zhang Nong , Zhang Chenghao , Qian Deyu , Han Changliang , Yang Sen
Published: January 2018

The longevity of grouting has a significant effect on the safe and sustainable operation of many engineering projects. A 500-day experiment was carried out to study the long-term mechanical behavior of nano silica sol grouting. The nano silica sol was activated with different proportions of a NaCl catalyst and cured under fluctuating temperature and humidity conditions. The mechanical parameters of the grout samples were tested using an electrohydraulic uniaxial compression tester and an improved Vicat instrument. Scanning electron microscope, X-ray diffraction, and ultrasonic velocity tests were carried out to analyze the strength change micro-mechanism. Tests showed that as the catalyst dosage in the grout mix is decreased, the curves on the graphs showing changes in the weight and geometric parameters of the samples over time could be divided into three stages, a shrinkage stage, a stable stage, and a second shrinkage stage. The catalyst improved the stability of the samples and reduced moisture loss. Temperature rise was also a driving force for moisture loss. Uniaxial compressive stress-strain curves for all of the samples were elastoplastic. The curves for uniaxial compression strength and secant modulus plotted against time could be divided into three stages. Sample brittleness increased with time and the brittleness index increased with higher catalyst dosages in the latter part of the curing time. Plastic strength-time curves exhibit allometric scaling. Curing conditions mainly affect the compactness, and then affect the strength.
Novel Hybrid Formulations Based on Thiourea Derivatives and Core@Shell Fe3O4@C18 Nanostructures for the Development of Antifungal Strategies
Authors: Limban Carmen , Missir Alexandru , Caproiu Miron , Grumezescu Alexandru , Chifiriuc Mariana , Bleotu Coralia , Marutescu Luminita , Papacocea Marius , Nuta Diana
Published: January 2018

The continuously increasing global impact of fungal infections is requiring the rapid development of novel antifungal agents. Due to their multiple pharmacological activities, thiourea derivatives represent privileged candidates for shaping new drugs. We report here the preparation, physico-chemical characterization and bioevaluation of hybrid nanosystems based on new 2-((4-chlorophenoxy)methyl)-N-(substituted phenylcarbamo-thioyl)benzamides and Fe3O4@C18 core@shell nanoparticles. The new benzamides were prepared by an efficient method, then their structure was confirmed by spectral studies and elemental analysis and they were further loaded on Fe3O4@C18 nanostructures. Both the obtained benzamides and the resulting hybrid nanosystems were tested for their efficiency against planktonic and adherent fungal cells, as well as for their in vitro biocompatibility, using mesenchymal cells. The antibiofilm activity of the obtained benzamides was dependent on the position and nature of substituents, demonstrating that structure modulation could be a very useful approach to enhance their antimicrobial properties. The hybrid nanosystems have shown an increased efficiency in preventing the development of Candida albicans (C. albicans) biofilms and moreover, they exhibited a good biocompatibility, suggesting that Fe3O4@C18core@shell nanoparticles could represent promising nanocarriers for antifungal substances, paving the way to the development of novel effective strategies with prophylactic and therapeutic value for fighting biofilm associated C. albicans infections.
Curcumin-Artemisinin Coamorphous Solid: Xenograft Model Preclinical Study
Authors: Mannava M. , Suresh Kuthuru , Kumar Bommaka Manish , Bhavani Konga Durga , Nangia Ashwini
Published: January 2018

Curcumin is a natural compound present in Indian spice turmeric. It has diverse pharmacological action but low oral solubility and bioavailability continue to limit its use as a drug. With the aim of improving the bioavailability of Curcumin (CUR), we evaluated Curcumin-Pyrogallol (CUR-PYR) cocrystal and Curcumin-Artemisinin (CUR-ART) coamorphous solid. Both of these solid forms exhibited superior dissolution and pharmacokinetic behavior compared to pure CUR, which is practically insoluble in water. CUR-ART coamorphous solid showed two fold higher bioavailability than CUR-PYR cocrystal (at 200 mg/kg oral dose). Moreover, in simulated gastric and intestinal fluids (SGF and SIF), CUR-ART is stable up to 3 and 12 h, respectively. In addition, CUR-PYR and CUR-ART showed no adverse effects in toxicology studies (10 times higher dose at 2000 mg/kg). CUR-ART showed higher therapeutic effect and inhibited approximately 62% of tumor growth at 100 mg/kg oral dosage of CUR in xenograft models, which is equal to the positive control drug, doxorubicin (2 mg/kg) by i.v. administration.
Suitability of Different Variants of Polyethylene Glycol Impregnation for the Dimensional Stabilization of Oak Wood
Authors: Meints Tillmann , Hansmann Christan , Gindl-Altmutter Wolfgang
Published: January 2018

The common method to impregnate wood with polyethylene glycol (PEG) is to store the samples for several weeks in aqueous PEG-solution, allowing for diffusion of PEG into the wood. As this method is poorly suited for industrial application, an alternative approach based on vacuum-pressure treatment is evaluated in the present study. Using European oak wood and three variants of PEG, including silane-functionalized PEG, impregnation experiments at different PEG concentrations were performed. Significant uptake of PEG resulted in clearly altered wood-water relations and improved dimensional stability of oak wood. These results are discussed in terms of stability in humid and aqueous environments, and in terms of effects of the anatomy of oak wood on differences in dimensional stabilization observed along the radial and tangential anatomical directions, respectively. While both of the PEG variants perform better with an anti-shrinkage efficiency of up to 80%, the PEG-silane variant performs less effectively in this respect; however PEG-silane is clearly predominant in case of water extraction.
Acknowledgement to Reviewers of Recycling in 2017
Authors:   Recycling Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Recycling maintains high quality standards for its published papers. In 2017, a total of 24 papers were published in the journal.[...]
Christianity, Antisemitism, and the Holocaust
Authors: Munson Henry
Published: January 2018

There is, in principle, a fundamental difference between Nazi racial antisemitism and the traditional anti-Judaism of Christianity. The church’s official view has been that conversion transforms a Jew into a Christian, whereas the Nazi view was that a Jewish convert to Christianity remained a Jew. Nevertheless, the distinction between racial and religious antisemitism has often been less clear-cut than is often claimed by those who claim that Christian churches bear no responsibility for the Holocaust. That is not to say that it is illusory, just that it has often been less clear-cut than is often claimed. During the Holocaust and the decades that preceded it, Christian clergy often stressed the same themes as the Nazis, notably with respect to the Jews being “parasitic” capitalists exploiting Christians, as well as communists seeking to overthrow the governments and traditional Christian values of Europe (Passelecq and Suchecky 1997, pp. 123–36). We shall see that these clerics often also spoke of Jews in racial, as well as religious terms. Conversely, the Nazis often exploited traditional Christian themes, such as the diabolical nature of the Jew, the image of the Jew as “Christ-killer,” and the contrast between “carnal” (materialistic) Judaism and spiritual Christianity. In other words, the Nazis effectively exploited two millennia of Christian demonization of the Jew. Most scholars who have studied the role of the Christian churches during the Holocaust are well aware of most of these facts (Barnett 1992; Bergen 1996; Ericksen and Heschel 1999a; Kertzer 2001). Yet many comparative studies of religion and violence ignore the role played by Christian churches during the Holocaust—apparently on the assumption that the most horrific mass murder in human history was a purely secular phenomenon. In fact, some prominent scholars, including the best-selling authors Karen Armstrong and—incredibly—Rabbi Jonathan Sacks, go so far as to attribute the Shoah to the demise of religious values in Europe (Armstrong 2014; Sacks 2015)! This article is an attempt to correct these mistaken assumptions.
Wetland Mapping Using SAR Data from the Sentinel-1A and TanDEM-X Missions: A Comparative Study in the Biebrza Floodplain (Poland)
Authors: Mleczko Magdalena , Mróz Marek
Published: January 2018

This research is related to the eco-hydrological problems of the herbaceous wetland drying and biodiversity loss in the floodplain lakes of the Middle Basin of the Biebrza River (Poland). An experiment was set up, with its main goals as follows: (i) mapping the vegetation types and the temporarily or permanently flooded areas, and (ii) comparing the usefulness of the C-band Sentinel-1A (S1A) and X-band TerraSAR-X/TanDEM-X (TSX/TDX) for mapping purposes. The S1A imagery was acquired on a regular basis using the dual polarization VV/VH and the Interferometric Wide Swath Mode. The TSX/TDX data were acquired in quad-pol, a fully polarimetric mode, during the Science Phase. The paper addresses the following aspects: (i) wetland mapping with the S1A multi-temporal series; (ii) wetland mapping with the fully polarimetric TSX/TDX data; (iii) comparing the wetland mapping using dual polarization TSX/TDX subsets, that is, the HH-HV, HH-VV and VV-VH; (iv) comparing wetland mapping using the S1A and TSX/TDX data based on the same polarization (VV-VH); (v) studying the suitability of the Shannon Entropy for wetland mapping; and (vi) assessing the contribution of interferometric coherence for wetland classification. Though the experimental results show the main limitations of the S1A dataset, they also highlight the good accuracy that can be achieved using the TSX/TDX data, especially those taken in fully polarimetric mode. Some practical outcomes significant for the study area management using SAR were also described.
Solar Radiation Pressure Models for BeiDou-3 I2-S Satellite: Comparison and Augmentation
Authors: Wang Chen , Guo Jing , Zhao Qile , Liu Jingnan
Published: January 2018

As one of the most essential modeling aspects for precise orbit determination, solar radiation pressure (SRP) is the largest non-gravitational force acting on a navigation satellite. This study focuses on SRP modeling of the BeiDou-3 experimental satellite I2-S (PRN C32), for which an obvious modeling deficiency that is related to SRP was formerly identified. The satellite laser ranging (SLR) validation demonstrated that the orbit of BeiDou-3 I2-S determined with empirical 5-parameter Extended CODE (Center for Orbit Determination in Europe) Orbit Model (ECOM1) has the sun elongation angle (ε angle) dependent systematic error, as well as a bias of approximately −16.9 cm. Similar performance has been identified for European Galileo and Japanese QZSS Michibiki satellite as well, and can be reduced with the extended ECOM model (ECOM2), or by using the a priori SRP model to augment ECOM1. In this study, the performances of the widely used SRP models for GNSS (Global Navigation Satellite System) satellites, i.e., ECOM1, ECOM2, and adjustable box-wing model have been compared and analyzed for BeiDou-3 I2-S satellite. In addition, the a priori SRP models are derived based on analytical cuboid box model and empirically spectra analysis, respectively. Use of the a priori model combined with ECOM1 was finally demonstrated to reduce the ε-angle-dependent systematic error, and thus improved the radial orbit accuracy by nearly 35 per cent when compared to the solution with standalone ECOM1, as revealed by the one way SLR residuals.
Fine-Resolution Precipitation Mapping in a Mountainous Watershed: Geostatistical Downscaling of TRMM Products Based on Environmental Variables
Authors: Zhang Yueyuan , Li Yungang , Ji Xuan , Luo Xian , Li Xue
Published: January 2018

Accurate precipitation data at a high spatial resolution are essential for hydrological, meteorological, and ecological research at regional scales. This study presented a geostatistical downscaling-calibration procedure to derive the high spatial resolution maps of precipitation over a mountainous watershed affected by a monsoon climate. Based on the relationships between precipitation and other environmental variables, such as the Normalized Difference Vegetation Index (NDVI) and digital elevation model (DEM), a regression model with a residual correction method was applied to downscale the Tropical Rainfall Measuring Mission (TRMM) 3B43 product from coarse resolution (25 km) to fine resolution (1 km). Two methods, geographical difference analysis (GDA) and geographical ratio analysis (GRA), were used to calibrate the downscaled TRMM precipitation data. Monthly 1 km precipitation data were obtained by disaggregating 1 km annual downscaled and calibrated precipitation data using monthly fractions derived from original TRMM data. The downscaled precipitation datasets were validated against ground observations measured by rain gauges. According to the comparison of different regression models and residual interpolation methods, a geographically-weighted regression kriging (GWRK) method was accepted to conduct the downscaling of TRMM data. The downscaled TRMM precipitation data obtained using GWRK described the spatial patterns of precipitation reasonably well at a spatial resolution of 1 km with more detailed information when compared with the original TRMM precipitation. The results of validation indicated that the GRA method provided results with higher accuracy than that of the GDA method. The final annual and monthly downscaled precipitation not only had significant improvement in spatial resolution, but also agreed well with data from the validation rain gauge stations (i.e., R2 = 0.72, RMSE = 161.0 mm, MAE = 127.5 mm, and Bias = 0.050 for annual downscaled precipitation during 2001 to 2015; and R2 = 0.91, RMSE = 22.2 mm, MAE = 13.5 mm, and Bias = 0.048 for monthly downscaled precipitation during 2001 to 2015). In general, the downscaling-calibration procedure is useful for complex mountainous areas with insufficient ground gauges.
Proposal of a Method to Determine the Correlation between Total Suspended Solids and Dissolved Organic Matter in Water Bodies from Spectral Imaging and Artificial Neural Networks
Authors: R. Veronez Maurício , Kupssinskü Lucas , T. Guimarães Tainá , Koste Emilie , Da Silva Juarez , De Souza Laís , Oliverio William , Jardim Rogélio , Koch Ismael , De Souza Jonas , Gonzaga Luiz , Mauad Frederico , Inocencio Leonardo , Bordin Fabiane
Published: January 2018

Water quality monitoring through remote sensing with UAVs is best conducted using multispectral sensors; however, these sensors are expensive. We aimed to predict multispectral bands from a low-cost sensor (R, G, B bands) using artificial neural networks (ANN). We studied a lake located on the campus of Unisinos University, Brazil, using a low-cost sensor mounted on a UAV. Simultaneously, we collected water samples during the UAV flight to determine total suspended solids (TSS) and dissolved organic matter (DOM). We correlated the three bands predicted with TSS and DOM. The results show that the ANN validation process predicted the three bands of the multispectral sensor using the three bands of the low-cost sensor with a low average error of 19%. The correlations with TSS and DOM resulted in R2 values of greater than 0.60, consistent with literature values.
A Localization-Free Interference and Energy Holes Minimization Routing for Underwater Wireless Sensor Networks
Authors: Khan Anwar , Ahmedy Ismail , Anisi Mohammad , Javaid Nadeem , Ali Ihsan , Khan Nawsher , Alsaqer Mohammed , Mahmood Hasan
Published: January 2018

Interference and energy holes formation in underwater wireless sensor networks (UWSNs) threaten the reliable delivery of data packets from a source to a destination. Interference also causes inefficient utilization of the limited battery power of the sensor nodes in that more power is consumed in the retransmission of the lost packets. Energy holes are dead nodes close to the surface of water, and their early death interrupts data delivery even when the network has live nodes. This paper proposes a localization-free interference and energy holes minimization (LF-IEHM) routing protocol for UWSNs. The proposed algorithm overcomes interference during data packet forwarding by defining a unique packet holding time for every sensor node. The energy holes formation is mitigated by a variable transmission range of the sensor nodes. As compared to the conventional routing protocols, the proposed protocol does not require the localization information of the sensor nodes, which is cumbersome and difficult to obtain, as nodes change their positions with water currents. Simulation results show superior performance of the proposed scheme in terms of packets received at the final destination and end-to-end delay.
Inclinometer Assembly Error Calibration and Horizontal Image Correction in Photoelectric Measurement Systems
Authors: Kong Xiaofang , Chen Qian , Wang Jiajie , Gu Guohua , Wang Pengcheng , Qian Weixian , Ren Kan , Miao Xiaotao
Published: January 2018

Inclinometer assembly error is one of the key factors affecting the measurement accuracy of photoelectric measurement systems. In order to solve the problem of the lack of complete attitude information in the measurement system, this paper proposes a new inclinometer assembly error calibration and horizontal image correction method utilizing plumb lines in the scenario. Based on the principle that the plumb line in the scenario should be a vertical line on the image plane when the camera is placed horizontally in the photoelectric system, the direction cosine matrix between the geodetic coordinate system and the inclinometer coordinate system is calculated firstly by three-dimensional coordinate transformation. Then, the homography matrix required for horizontal image correction is obtained, along with the constraint equation satisfying the inclinometer-camera system requirements. Finally, the assembly error of the inclinometer is calibrated by the optimization function. Experimental results show that the inclinometer assembly error can be calibrated only by using the inclination angle information in conjunction with plumb lines in the scenario. Perturbation simulation and practical experiments using MATLAB indicate the feasibility of the proposed method. The inclined image can be horizontally corrected by the homography matrix obtained during the calculation of the inclinometer assembly error, as well.
Underdetermined Wideband DOA Estimation for Off-Grid Sources with Coprime Array Using Sparse Bayesian Learning
Authors: Qin Yanhua , Liu Yumin , Liu Jianyi , Yu Zhongyuan
Published: January 2018

Sparse Bayesian learning (SBL) is applied to the coprime array for underdetermined wideband direction of arrival (DOA) estimation. Using the augmented covariance matrix, the coprime array can achieve a higher number of degrees of freedom (DOFs) to resolve more sources than the number of physical sensors. The sparse-based DOA estimation can deteriorate the detection and estimation performance because the sources may be off the search grid no matter how fine the grid is. This dictionary mismatch problem can be well resolved by the SBL using fixed point updates. The SBL can automatically choose sparsity and approximately resolve the non-convex optimizaton problem. Numerical simulations are conducted to validate the effectiveness of the underdetermined wideband DOA estimation via SBL based on coprime array. It is clear that SBL can obtain good performance in detection and estimation compared to least absolute shrinkage and selection operator (LASSO), simultaneous orthogonal matching pursuit least squares (SOMP-LS) , simultaneous orthogonal matching pursuit total least squares (SOMP-TLS) and off-grid sparse Bayesian inference (OGSBI).