bluuebunny/crossref_metadata_2025 huggingface dataset:
Body Part Terms as a Source of Chained Metonymies in Hausa
Authors: Gwarzo Yusuf Ahmed
Published: September 2024

This study aims to analyze the serial structure of chained metonymies related to body parts in Hausa. Specifically, it seeks to identify the metonymic mappings frequently found within these chained metonymies and the most prevalent semantic domains where they occur. The analysis employs the chained metonymy model proposed by Hilpert (2005) and the conceptual metonymy theory developed by Lakoff and Johnson (1980), which was later refined by Radden and Dirven (2007). Data for this study were collected through participant observations, with the literal meanings of each concrete noun expression identified. Additionally, other meanings evoking multiple conceptual shifts were also identified and collected. The study found that the most common metonymic mapping is the E-E-C metonymy, occurring eight times, followed by the E-C metonymy, which occurs six times, and the E-E metonymy, which occurs twice. Another significant finding is that various body parts are extensively used by Hausa speakers to create conceptual expressions through chained metonymies. The findings also support Hilpert's (2005) assertion that chained metonymies typically begin with E-metonymies. The analysis shows that no chained metonymy starts with C-metonymies, indicating that C-metonymies are rarely found at the beginning of a chained metonymy.
A clinical observation of diagnosis of late-onset Fabry desiase in patient with hypertrophic cardiomyopathy on the basis of the «V.A. Baranov republican hospital» in Karelia Republic
Authors: Barysheva O. Yu. , Vezikova N. N. , Vybach M. V. , Smirnova D. V.
Published: September 2024

BACKGROUND. Fabry disease is a rare hereditary x-linked liesomic accumulation disease, due to a decrease in the activity of α-galactosidase A, then glicosfinggolipids accumulates in different tissues of the body. The complexity of diagnosing of Fabry disease due to its rarity, as well as a variety of symptoms and syndromes, which can lead to an incorrect diagnosis. Early diagnosis of Fabry disease is crucial for the timely therapeutic intervention and a slowdown in the development of threatening organ damage... PATIENTS AND METHODS. The article presents a clinical observation of diagnosis of late-onset Fabry desiase in patient with hypertrophic cardiomyopathy, CKD C3a and stroke in patient’s history. he decrease in the activity of α-galactosidase A was assessed by determining the concentration of globotrializesfingosin (LySo-GB3) in dry stains of blood by tandem mass spectrometry. RESULTS. The first patient with Fabry's disease in the Republic of Karelia was found in the cardiology department. The patient was offered enzyme replacement therapy, and proband's relatives were offered family screening. At the time of publication, there was no decrease in the activity of α-galactsidase-A among 27 patients on the program hemodialysis. Screening still in progress. CONCLUSION. The results of the study confirm the rarity of the disease and a wide range of its manifestations. The clinical case illustrates the development of cardiovascular, cerebrovascular complications, the progression of renal failure in the Fabry disease.
Original Public Meaning and Pregnancy’s Ambiguities
Authors: Bernick Evan
Published: September 2024

Relying on 1868 abortion statutes, the 2022 Supreme Court held in Dobbs v. Jackson Women’s Health Organization that no federal constitutional right to abortion exists. Mere months later, a petition for certiorari asked the Court to determine that “person” in the Fourteenth Amendment includes prenatal existence, which would require criminalization of abortion in all states. The petitioners cited Dobbs and claimed the authority of legal history in 1868 and before. These arguments will be heard again, and they are increasingly framed in terms of the “original public meaning” of the Fourteenth Amendment.

This Article refutes these arguments on their own terms. It looks at 1868, but it doesn’t stop at statutes, treatises, or dictionaries. Instead, it looks at the reality of pregnancy in 1868, as experienced by the public—in particular, by women and their doctors. This was a reality full of ambiguities. Pregnancy was not medically diagnosable until quickening; ideas of prenatal development were fluid and women let doctors take their miscarried fetal tissue and stillborn babies away for scientific study; and pregnancy loss was common, expected, and impossible to distinguish from abortion.

Women and their doctors lived these ambiguities. Nothing in the laws in 1868 changed them. These ambiguities similarly negate any possibility that the original public meaning of “person” in the Fourteenth Amendment included prenatal existence.
Dosimetric Comparison of Accelerated Partial Breast Irradiation Techniques: Multicatheter Interstitial Brachytherapy and Conformal External Beam Radiotherapy
Authors: Bryantseva Zh. V. , Akulova I. A. , Yaganova T. S. , Ulrikh D. G. , Tabagua T. T. , Krivorotko P. V. , Novikov S. N.
Published: September 2024

Purpose: To compare dosimetric plans obtained in patients with breast cancer (BC) that underwent accelerated partial breast irradiation (APBI) by conformal external beam radiotherapy (EBRT) or interstitial high dose rate brachytherapy (HDRB).

Material and methods: From 2017 to 2022 APBI was performed in 210 patients with stage I–II BC (рТ1N0M0–pT2N0M0). APBI was delivered to the tumor bed: in 99 cases — by EBRT, in another 111 patients — by HDRB. Leﬅ breast was irradiated in 101 women: in 51 women using HDRB, in 50 patients — by EBRT. Following dosimetric parameters were used for comparison of the dosimetric plans: Dmax – maximum dose in the organ at risk; Dmed – mean dose in the organ at risk (heart, leﬅ main coronary artery and its descending branch, ipsilateral lung, breast, skin and subcutaneous tissues).

Results: When the tumor bed was irradiated by HDRB, in comparison with EBRT, Dmax for the skin and subcutaneous tissue decreases from 98.4 % to 68.7 %, р < 0.002. The use of HDRB made it possible to reduce the radiation load on the ipsilateral lung: Dmax decreased from 71.9 % to 42.7 % , р < 0.002; Dmed was 5.5 % for HDRB and 2.9 % for EBRT, р > 0.05. On the contrary EBRT associated with higher dose to the breast Dmed breast — 46 % in comparison with HDRB Dmed breast — 16.5 % , р < 0.002. Dose to the heart was higher with HDBT Dmax heart — 20.2 %, Dmed heart was 4.9 % than with EBRT Dmax heart — 14.4 %, Dmed heart — 0.8 %. Dose to the left coronary artery with HDRB Dmax — 6.5 % , Dmed — 3.9 % was higher than with EBRT Dmax — 3.3 % , Dmed — 1.3 % . Dose to the descending branch of the left coronary artery was higher with HDRB Dmax — 12.6 % , Dmed — 9.3 % than with EBRT Dmax — 8.9 % and Dmed — 3.4 % . But this differences were non-significant (р > 0.05).

Conclusions. APBI by HDRB associated by significant reduction of the radiation dose to the ipsilateral breast lung, breast, skin and subcutaneous tissues.
Intra-Arterial Chemotherapy for Locally Advanced Oral Cavity Cancer
Authors: Vyzhigina B. B. , Kropotov M. A. , Dolgushin B. I. , Safarov D. A. , Pogrebnyakov I. V. , Alieva S. B.
Published: September 2024

Introduction: The standard treatment for locally advanced oral cavity cancer is surgery with followed by chemoradiotherapy Surgical treatment carries serious external and aesthetic risks and a long period of rehabilitation. On the other hand, standard chemoradiation treatment does not achieve adequate results. Intra-arterial chemotherapy is a promising treatment option. This method allows targeting the tumor to be while minimizing systemic factors and organ preservation, and the quality of life of the patients.

Purpose: To compare the results of treatment of patients with locally advanced oral cancer using induction intra-arterial chemotherapy and surgical treatment at the first step.

Material and methods: 62 patients were treated from 2017 to 2023 with locally advanced oral cancer. 23 patients underwent induction chemotherapy according to the DCF regimen with intra-arterial administration of cisplatin and docetaxel. In the second group, 39 patients underwent combined treatment with surgical treatment at the first step. The primary endpoint of the study was overall and disease-free survival. Secondary — objective response, treatment toxicity and the occurrence of prognostic factors in the intra-arterial chemotherapy group.

Results: The duration of follow-up of patients in the intra-arterial group was 20.37 (CI 13.23–25.87) and in the surgery group 32.6 (CI 17.1–43.6) months. 1-year overall survival (OS) in the intra-arterial group and in the surgical group was 84.1 % and 69.2 % (p = 0.582), relapse-free survival (RFS) — 77.9 % and 62.5 % (p = 0.944). A subgroup analysis revealed an improvement in OS in patients treated with one arterial basin (p = 0.005). 1-year OS aﬅer induction chemotherapy for complete response, partial response, and stabilization were 90.9, 67.5, and 0 % (p < 0.001), respectively. 1-year RFS for complete response, partial response, and stabilization were 80, 76.2, and 0 % (p < 0.000), respectively.

Conclusions: Intra-arterial chemotherapy has equivalent eﬃcacy in terms of survival in patients with locally advanced tumors, oral cavity conclusion is indicated.
ET/CT-18F-fluorodeoxyglucose in POEMS syndrome. Clinical Case
Authors: Khakulova B. M. , Subbotin A. S. , Pronin A. I. , Semenova A. A.
Published: September 2024

A brief review of the literature and our own detailed description of POEMS syndrome according to PET/CT data with 18F FDG in a 26-year-old patient are provided. A comprehensive examination was carried out and appropriate systemic therapy was prescribed.
A mini-update on chronic rhinosinusitis
Authors: Darougar Sepideh , Hematyar Masoumeh , Savoji Pantea Bozorg
Published: September 2024

Chronic rhinosinusitis (CRS) is an inflammatory disorder of the paranasal sinuses and the nasal cavity lasting longer than 12 weeks. This disease is a common clinical syndrome with significant monetary burden due to the high costs of medical visits, diagnostic tests, medications, and surgical therapies. CRS without nasal polyposis (CRSsNP) is the most common subtype of CRS, accounting for about 70% of all patients. Other subtypes include CRS with nasal polyposis (CRSwNP) and allergic fungal rhinosinusitis (AFRS). CRSwNP has the worldwide prevalence of 2% to 4% and is often accompanied by type 2 inflammation and asthma as a comorbid condition. Pediatric chronic sinusitis is distinct from adult chronic sinusitis and is currently considered an infectious process, characterized by persistent inflammation representing an exaggerated immune response to an external stimulus. The medical and surgical management of CRS has been remarkably modified in the past two decades. The aim of this study was to present an update on CRS based on the recent years’ literature.
Diagnostic and prognostic role of NLR in testicular cancer
Authors: Sarejloo Shirin , Babadi Saghar , Khanzadeh Shokoufeh , Salimi Amirhossein , Clark Alec , Khazaeli Dinyar , Khanzadeh Monireh , Ghaedi Arshin , Lucke-Wold Brandon
Published: September 2024

Background: To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa).
Methods: The search was conducted on PubMed, Scopus, and Web of Science up to November 21, 2021. Finally, a total of 31 studies were included in this review.
Results: NLR was higher in tCa patients compared to healthy controls and benign testis pathologies, and decreased significantly after orchiectomy. An elevated NLR predicts poor prognosis, advanced stage, presence of nodal or distant metastases, contralateral tumor development, lower time-to-cancer specific death, worse OS, and poorer response to chemotherapy. However, NLR could not differentiate between seminomas and non-seminomatous tCa.
Discussion: NLR has a significant diagnostic and prognostic value in tCa.
Redefining hemorrhoid therapy with endoscopic polidocanol foam sclerobanding
Authors: Rao Asad Gul , Nashwan Abdulqadir J
Published: September 2024

Hemorrhoids are a common and painful condition, with conventional treatments such as endoscopic rubber band ligation (ERBL) and injection sclerotherapy often falling short due to high recurrence rates and significant post-operative pain. A clinical trial by Qu et al introduces a novel approach called endoscopic poli-docanol foam sclerobanding (EFSB). This multicenter randomized trial involved 195 patients with grade II and III internal hemorrhoids and demonstrated that EFSB significantly reduced recurrence rates and post-procedural pain while improving symptom relief and patient satisfaction compared to ERBL. The study's strengths include its robust design, comprehensive outcome evaluation, and patient-centered approach. Despite limitations such as the single-blind design and relatively short follow-up period, the findings suggest that EFSB could enhance clinical practice by offering a more effective and patient-friendly treatment option. Further research is needed to validate these results and explore the long-term benefits and cost-effectiveness of EFSB.
Dual-targeted treatment for inflammatory bowel disease: Whether fecal microbiota transplantation can be an important part of it
Authors: Zhang Zi-Ning , Sang Li-Xuan
Published: September 2024

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disease. With the emergence of biologics and other therapeutic methods, two biologics or one biologic combined with a novel small-molecule drug has been proposed in recent years to treat IBD. Although treatment strategies for IBD are being optimized, their efficacy and risks still warrant further consideration. This editorial explores the current risks associated with dual-targeted treatment for IBD and the great potential that fecal microbiota transplantation (FMT) may have for use in combination therapy for IBD. We are focused on addressing refractory IBD or biologically resistant IBD based on currently available dual-targeted treatment by incorporating FMT as part of this dual-targeted treatment. In this new therapy regimen, FMT represents a promising combination therapy.
Computed tomography-based multi-organ radiomics nomogram model for predicting the risk of esophagogastric variceal bleeding in cirrhosis
Authors: Peng Yu-Jie , Liu Xin , Liu Ying , Tang Xue , Zhao Qi-Peng , Du Yong
Published: September 2024

BACKGROUND

Radiomics has been used in the diagnosis of cirrhosis and prediction of its associated complications. However, most current studies predict the risk of esophageal variceal bleeding (EVB) based on image features at a single level, which results in incomplete data. Few studies have explored the use of global multi-organ radiomics for non-invasive prediction of EVB secondary to cirrhosis.

AIM

To develop a model based on clinical and multi-organ radiomic features to predict the risk of first-instance secondary EVB in patients with cirrhosis.

METHODS

In this study, 208 patients with cirrhosis were retrospectively evaluated and randomly split into training (n = 145) and validation (n = 63) cohorts. Three areas were chosen as regions of interest for extraction of multi-organ radiomic features: The whole liver, whole spleen, and lower esophagus–gastric fundus region. In the training cohort, radiomic score (Rad-score) was created by screening radiomic features using the inter-observer and intra-observer correlation coefficients and the least absolute shrinkage and selection operator method. Independent clinical risk factors were selected using multivariate logistic regression analyses. The radiomic features and clinical risk variables were combined to create a new radiomics-clinical model (RC model). The established models were validated using the validation cohort.

RESULTS

The RC model yielded the best predictive performance and accurately predicted the EVB risk of patients with cirrhosis. Ascites, portal vein thrombosis, and plasma prothrombin time were identified as independent clinical risk factors. The area under the receiver operating characteristic curve (AUC) values for the RC model, Rad-score (liver + spleen + esophagus), Rad-score (liver), Rad-score (spleen), Rad-score (esophagus), and clinical model in the training cohort were 0.951, 0.930, 0.801, 0.831, 0.864, and 0.727, respectively. The corresponding AUC values in the validation cohort were 0.930, 0.886, 0.763, 0.792, 0.857, and 0.692.

CONCLUSION

In patients with cirrhosis, combined multi-organ radiomics and clinical model can be used to non-invasively predict the probability of the first secondary EVB.
Liver transplantation following two conversions in a patient with huge hepatocellular carcinoma and portal vein invasion: A case report
Authors: Liang Li-Cong , Huang Wen-Sou , Guo Zhao-Xiong , You Hong-Ji , Guo Yong-Jian , Cai Ming-Yue , Lin Li-Teng , Wang Guo-Ying , Zhu Kang-Shun
Published: September 2024

BACKGROUND

Surgical resection and liver transplantation (LT) are the most effective curative options for hepatocellular carcinoma (HCC). However, few patients with huge HCC (> 10 cm in diameter), especially those with portal vein tumor thrombus (PVTT), can receive these treatments. Selective internal radiation therapy (SIRT) can be used as a conversion therapy for them because it has the dual benefit of shrinking tumors and increasing residual hepatic volume. However, in patients with huge HCC, high lung absorbed dose often prevents them from receiving SIRT.

CASE SUMMARY

A 35-year-old man was admitted because of emaciation and pain in the hepatic region for about 1 month. The computed tomography scan showed a 20.2 cm × 19.8 cm tumor located in the right lobe–left medial lobes with right portal vein and right hepatic vein invasion. After the pathological type of HCC was confirmed by biopsy, two conversions were presented. The first one was drug-eluting bead transarterial chemoembolization plus hepatic arterial infusion chemotherapy and lenvatinib and sintilimab, converted to SIRT, and the second one was sequential SIRT with continued systemic treatment. The tumor size significantly decreased from 20.2 cm × 19.8 cm to 16.2 cm × 13.8 cm, then sequentially to 7.8 cm × 6.8 cm. In the meantime, the ratio of spared volume to total liver volume increased gradually from 34.4% to 55.7%, then to 62.9%. Furthermore, there was visualization of the portal vein, indicating regression of the tumor thrombus. Finally, owing to the new tumor in the left lateral lobe, the patient underwent LT instead of resection without major complications.

CONCLUSION

Patients with inoperable huge HCC with PVTT could be converted to SIRT first and accept surgery sequentially.
Analysis of real-world data for medical device evaluation: Chinese manual
Authors: Kasimova A. R. , Zhao Wenlong
Published: September 2024

Real-word data obtained using medical devices differ from the use of drugs. When using medical devices, the effectiveness is usually not in doubt, and the issues of biocompatibility, safety, and long-term use come to the fore. This article presents a translation of the clinical guidelines of the People’s Republic of China on planning and conducting studies on the use of medical devices in real-world clinical practice, as well as statistical processing of the information obtained in an abbreviated form.
Post Marketing evaluation of Anti Snake Venom (ASV) administered as a standard treatment for snakebite. Experience from western India
Authors: Patel Dhirubhai C , V B Sovani  , Patel N J
Published: September 2024

Aim: To study the safety profile and effectiveness of Anti Snake venom (ASV) in western India
Methods: This retrospective study gathered safety, epidemiological and clinical data on 157 snake bite patients admitted at Shri Sainath Hospital, in Dharampur, Gujarat, from July 2022 to February 2023. 
Results: Majority of the bites occurred between August and November. There were 88 males between 5 and 70 yrs. (mean 39.14 yrs.), 69 females between 2 and 70 years (mean 40.32 yrs.).  6 of these were children ranging from 2 to 12 years.134 were agricultural labourers.
120 cases were analysable. 17 had neurotoxicity and 103 had haemotoxicity. Mean (SD) number of vials used was 10.1(6.2), time to discontinue ASV was 3.0(5.2) hours, and duration of hospital stay was 4.5(2.6) days. Patients bitten by saw scaled vipers were discharged early. In Russel’s Viper bites, number of vials used, was higher if the bite to needle time was less than 6 hours
9 patients suffered 24 adverse events, with two possible cases of anaphylaxis. One case had urticaria, itching and tachycardia as a triad. The remaining were isolated events of mild urticaria, itching, tachycardia, hypotension, cough, rigor.
Conclusion:  All cases were successfully managed with no fatalities or severe comorbidities. Adverse events were reported in 5.7% cases. Mean of 10.1 vials were needed for control of envenomation, a number much less that national guidelines. The ASV brand used was well tolerated. Patients who were brought late suffered more renal complications
Coverage of Japanese Encephalitis Vaccine in Kalaburagi City, Karnataka, India: A Cross-Sectional Study after the Vaccination Campaign
Authors: Sangita S  , G. Ajay Kumar  , Ramesh
Published: September 2024

INTRODUCTION: Group B arbovirus is the cause of Japanese encephalitis (JE), with a 20–40% case fatality rate, is spread by the culicine mosquito.1 Due to the rise in incidence reported in Karnataka, JE immunization campaign with inactivated JENVAC vaccine was conducted in December 2022 in 10 Karnataka districts including Kalaburagi, an undeveloped district vaccinating children aged 1-15 years.2
OBJECTIVES: To evaluate vaccine coverage and the challenges faced among children in Kalaburagi city, following the campaign.
MATERIALS & METHODS: 210 children were chosen using 30*7 cluster sample method.3 Eligible children residing at Kalaburagi city were included, although recently immigrated and immunized residents of surrounding talukas were not. This survey was conducted two months following the campaign. JE vaccination status was assessed using a pretested, semi-structured questionnaire from reliable informants. SPSS software version 16 was used for analysis after the data were entered into an Excel sheet. Statistical tests like Chisquare, frequency and percentage were used.
RESULTS: Of the 210 children, the majority were younger than five years old. Estimated vaccine coverage was 68.6% with the major reason being unawareness followed by hesitancy for vaccination with no significant association with sociodemographic factors.
CONCLUSION: Raising awareness through the media and medical professionals contributes to the vaccination's ability to lower the prevalence of JE and vaccinating nonvaccinators unless contraindicated.
İngiliz Kültür Tarihi ve İncelemeleri
Authors: Haykılıç Funda , Demir Ayşegül , Pınar Dolaykaya Mürüvvet Mira , Şentürk Emine , Arıkan Seda , Balcı Adem , Doğan Özger Pelin , Uçar Asya Sakine , Yazgı Cihan
Published: September 2024

Giriş
Zeynep Z. ATAYURT FENGE
İngiliz Toplumunda Çokkültürlülüğün Tarihi
Funda HAY KILIÇ
Birleşik Krallık’ta Ulusal Kimlikler
Ayşegül DEMİR
On Dokuzuncu Yüzyıl Macera Romanlarında İmparatorluk, Britanyalılık ve Milli Kimlik: Mercan Adası (1857) ve Define Adası (1883)
Mürüvvet Mira PINAR DOLAYKAYA
Altkültürden Akışkan Kimliğe: İngiliz Gençlik Kültürü
Emine ŞENTÜRK
Çokkültürlülük, Kültürlerarasılık ve Edebiyat
Seda ARIKAN
Bir Küçük Adadan Diğerine: Andrea Levy’nin Küçük Ada Romanında Kimliğini Arayan Küçük Adalılar
Adem BALCI
Çağdaş Britanya Tiyatrosunda Çokkültürlülük Temsilleri
Pelin DOĞAN ÖZGER
Salman Rushdie’nin Mağriplinin Son İç Çekişi Adlı Romanında Çokkültürlülük ve Tarihe Palimpsest-Ekfrastik
Bir Bakış
Asya Sakine UÇAR
Brexlit: Brexit Sonrası İngiliz Romanında Öne Çıkan İzlekler
Cihan YAZGI
Tekrarlayan Gebelik Kayıplarının Etiyolojik ve Demografik Verilerinin İncelenmesi
Authors: Seyhan Berna
Published: September 2024

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Effondrement De L’etat Libyen : Facteurs Et Indicateurs (Collapse Of The Libyan State: Factors and Indicators)
Authors: Lingoto Fortunat Bokeka
Published: September 2024

Observation of the Libyan state leads to the observation that this state is currently collapsed. This collapse results in its inability to carry out its sovereign missions. This situation is justifiable by distant causes which are endogenous and exogenous, as well as those which are close. These causes are palpable through indicators which are at the same time social, economic and political. It is with this in mind that this article is concerned with knowing how the Libyan state came to collapse? And what are the supporting evidence?
A Comprehensive Review of Strategies for Managing and Aligning Psychological Contracts to Enhance Organizational Commitment
Authors: Singh Aditi
Published: September 2024

Effective management and alignment of psychological contracts are pivotal in fostering enhanced organizational commitment. Psychological contracts, the unspoken agreements between employees and employers regarding mutual expectations, significantly influence workplace behavior and attitudes. This paper explores various strategies to manage and align these psychological contracts to bolster organizational commitment. Key strategies include clear communication, consistent leadership, recognition and rewards, and employee involvement. Additionally, promoting work life balance, ensuring fair treatment, and fostering a strong organizational culture are essential. Addressing psychological contract breaches promptly and effectively, along with continuous monitoring and evaluation, further solidifies trust and commitment. By implementing these strategies, organizations can create a supportive and engaging work environment, leading to improved employee satisfaction, loyalty, and performance.
A Study on Transnational Organised Crimes And Terrorism
Authors: Mamkuttathil Dr. Soman P , Palathingal Abdul Azeez
Published: September 2024

Transactional crimes are crimes that have actual or potential effects across national borders and crimes that are intrastate but offend fundamental values of the International Community. The terms is commonly used in the law enforcement and academic communities. Transactional organized crime refers specifically to transactional crime carried entirely crime organizations.
Fair Play Öğretim Öz-Yeterliği: Ölçek Geliştirme Çalışması
Authors: Aktaş İsmail , Sezen Balçıkanlı Gülfem
Published: September 2024

Bir yaşam ideali olan fair playin öğretim süreci, hem beden eğitimi ve spor hem eğitim hem de toplumsal düzen için önem arz etmektedir. Dolayısıyla bu çalışmada; bu öğretim sürecini etkili bir şekilde yürütebilmeye yönelik inancı temsil eden fair play öğretim öz-yeterliğini değerlendirmeye yarayan bir ölçme aracı geliştirmek amaçlanmıştır. Araştırma, faktör yapısını (1. Çalışma AFA n=348 DFA n=203) ve yapı geçerliğini (2. Çalışma n=528) test etmek için iki çalışma ile yürütülmüştür. Araştırma bulguları fair play öğretim öz-yeterlik ölçeğinin dört alt boyut ve 36 maddeden oluştuğunu ve bu yapının geçerli ve güvenilir sonuçlara işaret ettiğini göstermektedir. Ölçeğin eğitim politikalarını planlayan mercilere ve öğretmen yetiştiren kurumlara rehberlik edeceği düşünülmekte ve ölçeğin hem teorik hem de uygulamadaki kazanımları ve sınırlılıkları literatür eşliğinde tartışılmaktadır.
Strategies to Enhance Student Engagement and Retention in Higher Education Learning Environments
Authors: Shaıbou Abdoulaı Hajı
Published: September 2024

This paper explores strategies to enhance student engagement and retention in higher education institutions in Cameroon, focusing on interactive and collaborative learning tools. The study examines current practices, challenges, and the potential benefits of integrating innovative learning methods to foster an engaging educational environment. Using a mixed-methods approach, integrating both qualitative and quantitative data, this research identifies key factors influencing student engagement and retention. Surveys and interviews conducted with students, educators, and administrators provide comprehensive insights into the effectiveness of these learning tools. The findings highlight the positive impact of interactive platforms and collaborative activities on student motivation and academic success. Furthermore, the paper discusses the challenges faced in implementing these strategies, such as limited access to technology and inadequate training for educators. By addressing these issues, the study offers actionable recommendations for educators, policymakers, and stakeholders in the Cameroonian higher education sector to improve student outcomes and create a more supportive learning environment.
The implication of liquid hemostatic matrices to prevent hemorrhages during stereotactic biopsy of brain tumors
Authors: Rostorguev E. E. , Kuznetsova N. S. , Kavitskiy S. E. , Matevosyan B. V. , Reznik G. A. , Khatyushin V. E. , Kit O. I.
Published: September 2024

Purpose of the study. Development of a method for preventing hemorrhages during stereotactic biopsy of a brain tumor using liquid hemostatic matrices on the example of the drug "Floseal®".

Patients and methods. The target of the biopsy is the most representative area of tumor tissue according to the data of various modalities of MRI neuroimaging, including contrast-enhanced ones. Out of 133 patients, 60 patients with signs of intraoperative bleeding along the biopsy needle cannula were included in the study group. Further, patients with signs of intraoperative bleeding along the cannula of the biopsy needle were divided into 2 subgroups by independent sequential randomization. Control subgroup (n = 45): cases with signs of intraoperative bleeding of varying severity were operated on, according to the standard technique, without the use of the liquid hemostatic drug Floseal®. The main subgroup (n = 15): in case of intraoperative signs of bleeding, the hemostatic fluid drug Floseal® was injected into the area of tumor material removal.

Results. In 6.7 % of patients of the control subgroup, the formation of massive intracerebral hemorrhages was noted in the postoperative period. In 53.3 % of the observations of the control subgroup according to X-ray computer examinations of the brain, there were signs of minor hemorrhages at the point of tumor material collection, which did not require repeated surgical interventions. Postoperative hemorrhages after injection of the Floseal® liquid hemostatic matrix into the biopsy needle in the study subgroup were not detected according to neuroimaging X-ray CT.

Conclusion. A method of hemostasis has been developed to prevent hemorrhages using liquid hemostatic matrices. If signs of bleeding from the biopsy needle appeare, the introduction of a hemostatic matrix in the volume of 2 ml helps to manage bleeding intraoperatively, as well as to prevent the occurrence of hemorrhage in the early postoperative period.
Cellular, genomic and transcriptomic effects of secondary metabolites of the Hybrid Butterbur on the HeLa cell line
Authors: Zlatnik E. Yu. , Enin Ya. S. , Burov O. N. , Bondarenko E. S. , Sagakyants A. B. , Kutilin D. S. , Dzigunova Yu. V. , Novikova I. A. , Przhedetskiy Yu. V.
Published: September 2024

Purpose of the study.To evaluate the cellular, genomic (gene copy number) and transcriptomic (gene expression) effects ofP.hybridus(L.) secondary metabolites when they affect the HeLa cell line.

Materials and methods.The isolation of secondary metabolites from plant material and its identification were carried out by preparative chromatography. The composition was determined using mass spectrometric analysis, and the final verification of structural formulas was carried out by nuclear magnetic resonance at the Department of Natural Compounds, the Faculty of Chemistry of the Southern Federal University. The subsequent phase of the study was conducted using both cultural and molecular methods. HeLa cells were cultivated under standard conditions in a MEM medium. Once the confluence level was reached 75–80 %, the nutrient medium was replaced with the introduction of the studied compounds (at a concentration of 4 micrograms/ml) and cultivated for 72 hours. Cell mortality was determined using a NanoEnTek JuliFl counter (Korea) in the presence of 0.4 % trypan blue. The assessment of apoptosis following secondary metabolite exposure was conducted on a BD FACSCanto II flow cytometer using the FITC Annexin V Apoptosis Detection Kit I. The level of replication and expression of the genes responsible for apoptosis was assessed by digital droplet PCR (ddPCR).

Results.The following compounds were isolated and verified, and were assigned the following sequence numbers to facilitate their use in the experiment: No. 2 – 2,4-dihydroxy-2,5-dimethylfuran-3(2H)-one, No. 3 – 5-(hydroxymethyl) furan-2-carbaldehyde, No. 5.3 – 2,2,8-trimethyldecahydroazulene-5,6-dicarbaldehyde,P. hybridus(L.) At the stage of cell death assessment, it was found that the greatest effect was achieved in the compound under ordinal No. 2. However, the evaluation of the copy number and expression of theCASP8,CASP9,CASP3, BAX, BCL2, TP53, MDM2, CDKN1B, CDK1, CCND1, CCND3, andRB1genes by DD-PCR revealed the presence of apoptosis initiation in tumor cells at the molecular level under the action of compounds No. 2 and No. 5.3 obtained fromP. hybridus(L.).

Conclusion.The outcomes were multifeatured. Only compound 2,4-dihydroxy-2,5-dimethylfuran-3(2H)-one exhibited a pronounced cytostatic effect out of all compounds utilized in the experiment. Concurrently, the compound 2,2,8-trimethyldecahydroazulene-5,6-dicarbaldehyde was found to induce an increase in the expression of theCASP3, CASP8, TP53, andBAXgenes.
Changes in the concentration of freely circulating mutant DNA and wild-type DNA of the H3F3А (K27M) gene in the blood and cerebrospinal fluid of children with diffuse midline gliomas during a course of radiation therapy
Authors: Regentova O. S. , Bozhenko V. K. , Kudinova E. A. , Kulinich T. M. , Dzhikiya E. L. , Kaminskiy V. V. , Antonenko F. F. , Parkhomenko R. A. , Zelinskaya N. I. , Sidibe N. , Polushkin P. V. , Shevtsov A. I. , Bliznichenko M. A. , Solodkiy V. A.
Published: September 2024

Purpose of the study. To study the possibility of detecting freely circulating DNA of the H3F3A (K27M) gene in blood plasma and cerebrospinal fluid in the lumbar spine in children with diffuse midline gliomas (DMG) during a course of radiation therapy (RT).

Materials and methods. Molecular genetic studies were carried out by digital PCR. 96 samples of lumbar cerebrospinal fluid and 288 samples of peripheral blood plasma from 96 pediatric patients were analyzed. The concentration of circulating tumor (ctDNA) mutant DNA and wild-type DNA of the H3F3A (K27M) gene was determined in the studied material against the background of a course of RT. Lumbar cerebrospinal fluid sampling was performed once at the beginning of therapy, blood sampling was performed three times: The 1st test before the start of RT, the 2nd against the background of a total dose 10–15 Gy, and the 3rd after the completion of the RT course. Patients are divided into the following groups: patients with stabilization of brain tumor growth during early magnetic resonance (MR) control 3 months after completion of the course of RT; patients with disease progression during the same follow-up period who underwent radiation or chemoradiotherapy.

Results. When the disease stabilized after a RT course during treatment, the concentration level of both the mutant variant of ctDNA and wild-type ctDNA significantly decreased in the third blood fraction. The absence of changes or an increase in the concentration of mutant ctDNA and wild-type ctDNA of the H3F3A (K27M) gene by the end of the course of radiation therapy was typical for patients with disease progression in the form of the appearance of metastatic foci in the central nervous system or continued tumor growth. At the same time, the concentration of wild-type DNA of the H3F3A (K27M) gene in the group of patients with progression was higher both in the lumbar cerebrospinal fluid and in the first fraction of blood plasma.

Connclusion. Determination of the concentration and dynamics of circulating tumor DNA of the mutant and wild-type of the H3F3A (K27M) gene in blood plasma and lumbar cerebrospinal fluid in children with diffuse median gliomas of the brain during radiation therapy is promising from the point of view of predicting the effectiveness of therapy.
Okul Öncesi Öğretmenlerinin Kaynaştırma Eğitimi Uygulamalarına Yönelik Bir İnceleme (Siirt İli Örneği)
Authors: Acar Gök Sevgi , Epçaçan Cevdet , Gök Ömer
Published: September 2024

Araştırmanın amacı, okul öncesinde görev yapan öğretmenlerin kaynaştırma eğitimi uygulamalarına yönelik görüşlerini belirlemektir. Bu araştırmada kesitsel tarama modelinden yararlanılmıştır. Bu araştırmanın çalışma grubunda, 2022-2023 öğretim yılı ikinci yarıyılında Siirt İli merkezinde anaokulu ve ilkokul bünyesinde bulunan anasınıflarında görevli olan okul öncesi öğretmenleri bulunmaktadır. Verilerin toplanması amacıyla da 162 öğretmene ulaşılmıştır. Araştırmacıların hazırlamış olduğu Okul Öncesi Öğretmenlerinin Kaynaştırma Eğitimi Uygulamalarına Yönelik Görüşleri Ölçek formu araştırmanın veri toplama aracı olarak kullanılmıştır. Araştırmada elde edinilen veriler SPSS bilgisayar paket programı istifade edilerek elde edinilmiştir. İstatistiksel olarak; Betimsel İstatistik, Parametrik testlerden tek yönlü varyans analizi ve ilişkisiz gruplar t testi ile POST Hoc LSD testi uygulanmıştır. Okul öncesi öğretmenlerin maddelerin çoğuna birbirleri ile tutarlı ve olumlu görüş belirttikleri görülmüştür. Bu nedenle öğretmenlerin kaynaştırma eğitimi uygulamalarına yönelik görüşlerinin genel düzeyi olumludur. Cinsiyet, eğitim durumu, mesleki hizmet yılı, hizmet içi eğitim alma ve kaynaştırma eğitimini yeterli bulma değişkenleri açısından incelendiğinde okul öncesi öğretmenlerinin görüşlerinde anlamlı bir farklılık bulunmadığı belirlenmiştir. Kurumda çalışma süresi, sınıf öğrenci mevcudu, kaynaştırma öğrenci sayısı değişkenleri açısından öğretmen görüşlerinde anlamlı bir farklılık bulunduğu sonucuna ulaşıldığı belirtilebilir.
El Refuerzo Académico en Educación Básica Superior en el Área de Matemática
Authors: Fierro Barrera Gladys Teresa , Aldaz Aimacaña Eva del Rocio , Chipantiza Salán Clara Marlene , Llerena Mosquera Nubia Cecilia , Morales Villegas Nancy Rocio , Morales Armijo Paul Ariel , Bernal Párraga Augusto Paolo
Published: September 2024

El presente estudio analiza el impacto positivo que el refuerzo académico, específicamente en el campo de las matemáticas, puede tener en el rendimiento de los estudiantes de educación básica superior. El presente estudio tuvo como objetivo investigar la eficacia de distintos enfoques de refuerzo académico en el ámbito de las matemáticas, considerada una de las disciplinas que presenta mayores desafíos para los estudiantes. La investigación se realizó en diversas instituciones educativas, donde se evaluó el desempeño de los estudiantes antes y después de recibir apoyo académico. El estudio empleó una metodología mixta, combinando técnicas cuantitativas y cualitativas con el fin de obtener una perspectiva completa sobre el impacto del refuerzo académico. Los datos fueron recolectados mediante pruebas estandarizadas y entrevistas realizadas a estudiantes y docentes. Según los resultados obtenidos, los estudiantes que asistieron de manera regular a sesiones de refuerzo experimentaron un avance notable en su comprensión de los conceptos matemáticos, así como en su desempeño global en la materia. Se ha observado que la asistencia al refuerzo académico no solo contribuyó al progreso de los estudiantes en el área de matemáticas, sino que también incrementó su autoconfianza y motivación para involucrarse de manera activa en las clases convencionales. Por su parte, los profesores resaltaron la relevancia de ajustar las sesiones de refuerzo a las necesidades específicas de cada estudiante. Esto indica que un enfoque personalizado es fundamental para optimizar los beneficios del refuerzo académico. Un hallazgo significativo del estudio fue que la tutoría académica ayudó a disminuir las disparidades de rendimiento entre estudiantes con distintos niveles de habilidad, fomentando así una mayor equidad en la adquisición de conocimientos matemáticos. Esto sugiere que la aplicación eficaz del refuerzo académico puede constituir una herramienta de gran impacto para elevar el desempeño académico y promover un proceso de aprendizaje más inclusivo. En resumen, la importancia del refuerzo académico en la educación básica superior, específicamente en matemáticas, es enfatizada en este artículo. Se destaca la necesidad de implementar enfoques personalizados que se ajusten a las necesidades individuales de los estudiantes, con el fin de lograr un impacto positivo y perdurable en su desempeño académico.
El suicidio relacionado con problemas de pareja
Authors: Aguirre López Mardonio
Published: September 2024

El presente estudio evaluó el impacto de problemas de pareja en el estado mental y el riesgo de suicidio en 120 participantes mediante un cuestionario estructurado. Los resultados indican que un porcentaje significativo de los participantes experimenta sentimientos persistentes de tristeza, dificultades para conciliar el sueño y pensamientos suicidas, con un alto grado de conflicto en las relaciones de pareja. Las dificultades en la comunicación, la pérdida de interés en actividades placenteras, y la percepción de falta de apoyo emocional se asociaron estrechamente con un mayor riesgo de suicidio. Estos hallazgos subrayan la necesidad urgente de estrategias de intervención y apoyo específico para abordar los factores emocionales y relacionales que contribuyen al riesgo suicida, y destacan la importancia de enfoques integrales en la prevención del suicidio.
HOSPITALIDADE E COMENSALIDADE NAS FESTAS POPULARES: ESPAÇO DE SOCIABILIDADE E REECANTAMENTO DO MUNDO PELA PERSPECTIVA DO IMAGINÁRIO SOCIAL.
Authors: Paiva Lílian Pacheco Ferreira , Tricárico Luciano Torres
Published: September 2024

Este artigo é baseado em uma revisão literária que fundamentou esta pesquisa e tem a finalidade de apresentar uma discussão sobre a relação existente entre hospitalidade, comensalidade e festas populares. Este trabalho objetiva conhecer a significação desses termos para a manutenção do equilíbrio do convívio em grupo, observando o processo de sociabilidade existente na oferta de alimentos e bebidas, nos atos de estar junto e comer junto e na preservação das tradicionais festas populares tidas como projeções resultantes de um imaginário social coletivo. Metodologicamente realizou-se uma pesquisa bibliográfica, pautadas em uma revisão literária baseada em livros, revistas eletrônicas, artigos e sites que fundamentam esta pesquisa. Como resultados percebeu-se que o alimento e a comensalidade possuem uma função social, eles sempre fizeram com que os homens se aproximassem e que houvesse uma relação de troca de valores entre as sociedades. As festas possuem as características de unir e diferenciar, ao mesmo tempo, os que estão participando e os que estão de fora. É necessário preservar e proteger as festas populares como patrimônio brasileiro de maneira mais eficaz, com ações do poder público mais pontuais para essa finalidade, pois mesmo diante dessa multiplicidade de manifestações da cultura popular são incipientes os registros e salvaguardas das práticas culturais enquanto patrimônio imaterial.
ALGUMAS REFLEXÕES SOBRE A PRÁTICA DE SER PROFESSOR
Authors: Crivellaro Renan Elvis , Santos Franklin Noel dos , Capellini Raiane , Moraes Priscila Farias
Published: September 2024

O professor exerce um papel fundamental na transformação da sociedade, atuando como um mediador do processo de ensino-aprendizagem e como agente de desenvolvimento crítico e humano. Este artigo analisa a evolução histórica do papel do professor, desde suas origens tradicionais até o modelo contemporâneo de pedagogia crítica, que enfatiza a colaboração e o diálogo entre educadores e alunos. O texto discute a importância do relacionamento professor-aluno, destacando o impacto do exemplo do educador na formação ética e cidadã dos alunos. Aborda também a necessidade de constante aperfeiçoamento profissional, com foco na inovação pedagógica e na adaptação às novas tecnologias. O artigo conclui que o professor deve ser um pesquisador ativo da realidade em que atua, comprometido com a formação integral dos estudantes e com a promoção de uma educação que valorize a autonomia, o pensamento crítico e a cidadania. A educação, assim, é vista como um processo contínuo de aprendizado e renovação, tanto para os alunos quanto para os professores, que devem estar sempre prontos para enfrentar os desafios de uma sociedade em transformação.
TEOLOGIA, VIOLÊNCIA E INTOLERÂNCIA RELIGIOSA NO PARANÁ: UMA ANÁLISE DE CONJUNTURA
Authors: Quintas Michel Eriton , Gamboa Regina de Holanda
Published: September 2024

Desde os antigos registros de manifestações religiosas, passando pela concepção de ser humano na cultura arcaica grega, pela hegemonia cristão-católica na era medieval, pelos pressupostos éticos da teologia protestante que culminaram na formação de um sistema econômico, e chegando ao fenômeno religioso contemporâneo, a figura de Deus – ou deuses – exerce grande influência. Assim, importa atentar ao tipo de religiosidade presente, alinhada aos direitos humanos fundamentais ou emergentes, feitos instrumento de propagação de violências. Nesse sentido, com o objetivo de analisar apenas uma parcela do contexto religioso do Brasil, o presente artigo aplica o método da análise de conjuntura, juntamente de revisão e reflexão bibliográfica, para mapear casos de intolerância, compreender suas raízes e identificar possíveis transformações. Na medida em que a coleta de dados de diferentes dossiês da esfera pública aponta para um crescente número de casos de intolerância religiosa, muitas vezes praticados entre as próprias denominações religiosas, a pesquisa bibliográfica relacionada possibilita a compreensão de suas origens ou, ao menos, de alguns aspectos dela. Dessa forma, conclui-se que o presente artigo/análise de conjuntura, além de facilitar uma reflexão urgente, serve de ferramenta para que diferentes atores sociais promovam o respeito, uma religiosidade positiva e uma cultura de coexistência.
ESTRATÉGIAS PEDAGÓGICAS INCLUSIVAS NO ENSINO MÉDIO: REFLEXÕES A PARTIR DE UMA AÇÃO EDUCATIVA
Authors: Carvalho Célia Regina , Bonfim Laiane Nunes , Silva Lorena , Mendes Marianne Louise Marinho
Published: September 2024

O artigo relata a experiência de uma ação educativa focada na Educação Inclusiva (EI) com professores do ensino médio em uma escola pública de tempo integral em Petrolina-PE. A intervenção foi realizada em 2023 e envolveu cinco professoras, abordando estratégias pedagógicas para promover um ambiente escolar mais inclusivo e melhorar a qualidade de vida de todos os envolvidos. A atividade consistiu em uma palestra seguida de debate, destacando a importância de metodologias que considerem os recursos disponíveis e as necessidades dos alunos. As discussões enfatizaram a necessidade de formação continuada para os docentes, essencial para a implementação eficaz de práticas inclusivas. Os resultados revelaram pontos críticos como a discrepância entre teoria e prática docente, a falta de apoio institucional e a superlotação das salas de aula. A experiência evidenciou a relevância da formação colaborativa e contínua para os professores, bem como a necessidade de adaptar o ambiente escolar para atender à diversidade, promovendo uma educação de qualidade que valorize as diferenças individuais. A participação dos alunos na discussão foi identificada como uma oportunidade para enriquecer futuras intervenções, reforçando a importância de envolver todos os atores do ambiente escolar na promoção de uma educação inclusiva, especialmente no contexto pós-pandemia. Conclui-se que, embora a ação tenha sido significativa, a inclusão dos estudantes pode ampliar a eficácia de futuras iniciativas.