bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Coder Reliability on Reconstructing Archaeological Settlement Patterns from Satellite Imagery: a Case Study from South Africa
Authors: Sadr Karim
Published: May 2015

A large archaeological remote sensing project is underway to digitize and classify the pre‐colonial stone walled structures (SWS) on Google Earth satellite imagery in the southern part of Gauteng Province, South Africa. Over 7000 such SWS have been digitized in a study area of some 8000 km2. Several research assistants have been involved in classifying the structures. The problem is that different analysts may assign the same SWS to different types and even digitize their outline differently no matter how well they have been trained. Such inter‐analyst variability is a common problem in many fields. In order to minimize its impact, a thorough study of coder reliability in classification of remotely sensed Iron Age SWS has been initiated. The results show unacceptably high variability in the classification of individual SWS. Several contributing factors have been identified. Surprisingly, at the regional level, relatively high levels of inter‐analyst agreement are seen in the same data. The reason probably has to do with strong agreement on the classification of the most diagnostic structures. This may suffice to produce the replicable results at the regional level. Copyright © 2015 John Wiley & Sons, Ltd.
Centrosome nucleates numerous ephemeral microtubules and only few of them participate in the radial array
Authors: Alieva Irina B. , Berezinskaya Tatyana , Borisy Gary G. , Vorobjev Ivan A.
Published: May 2015

It is generally accepted that long microtubules (MTs) grow from the centrosome with their minus ends anchored there and plus ends directed towards cell membrane. However, recent findings show this scheme to be an oversimplification. To further analyze the relationship between the centrosome and the MT array we undertook a detailed study on the MTs growing from the centrosome after microinjection of Cy3 labeled tubulin and transfection of cells with EB1‐GFP. To evaluate MTs around the centrosome two approaches were used: path photobleaching across the centrosome area (Komarova et al., ) and sequential image subtraction analysis (Vorobjev et al., ). We show that about 50% of MTs had been nucleated at the centrosome are short‐living: their mean length was 1.8 ± 0.8 μm and their life span − 7 ± 2 s. MTs initiated from the centrosome also rarely reach cell margin, since their elongation was limited and growth after shortening (rescue) was rare. After initial growth all MTs associated with the centrosome converted to pause or shortening. After pause MTs associated with the centrosome mainly depolymerized via the plus end shortening. Stability of the minus ends of cytoplasmic MTs was the same as for centrosomal ones. We conclude that in fibroblasts (1) the default behavior of free MTs in the cell interior is biased dynamic instability (i.e., random walk of the plus ends with significant positive drift); (2) MTs born at the centrosome show “dynamic instability” type behavior with no boundary; and (3) that the extended radial array is formed predominantly by MTs not associated with the centrosome.
Implantation of a 29 mm sapien XT valve in a pediatric patient with an unstented right ventricular outflow tract
Authors: Rothman Abraham , Galindo Alvaro , Evans William N.
Published: May 2015

We describe a 29 mm Sapien XT valve implantation in a 10‐year‐old girl with repaired Tetralogy of Fallot, severe pulmonary regurgitation, and right ventricular dilatation, using the NovaFlex+ delivery system and the expandable introducer eSheath, without pre‐stenting of the right ventricular outflow tract. © 2015 Wiley Periodicals, Inc.
Expanding the armamentarium for effective PFO closure
Authors: Jumean Marwan , Kimmelstiel Carey
Published: May 2015

Key Points

PFO Closure with the Nit‐Occlud PFO Occlusion device is feasible and safe.

Residual shunting across the PFO at 6 months requires further definition.

Longer term follow‐up is required to establish clinical efficacy.
Bioresorbable drug‐eluting scaffold restenosis
Authors: Belardi Jorge A. , Albertal Mariano
Published: May 2015

Key Points

Bioresorbable coronary scaffold emerges as an attractive alternative to permanent scaffolds.

Bioresorbable scaffold restenosis, similar to permanent, appears strongly related to underexpansion.

The use of intravascular imaging should be recommended in patients undergoing bioresorbable scaffold implantation
Intravascular ultrasound predictors of acute side branch occlusion in coronary artery bifurcation lesions just after single stent crossover
Authors: Sakamoto Nobuo , Hoshino Yasuto , Mizukami Hiroyuki , Sugimoto Koichi , Yamaki Takayoshi , Kunii Hiroyuki , Nakazato Kazuhiko , Suzuki Hitoshi , Saitoh Shu‐ichi , Takeishi Yasuchika
Published: May 2015

Objectives

We aimed to assess the intravascular ultrasound (IVUS) predictors of acute side branch (SB) occlusions just after single stent crossover in percutaneous coronary intervention (PCI) for coronary bifurcation lesions.

Background

PCI for bifurcation lesions remains technically challenging and has more clinical complications such as SB occlusion than non‐bifurcation lesions. Although single stent crossover is the most common approach in treating bifurcation lesions, the predictors of acute SB occlusion are unclear.

Methods

Single stent crossover was performed on 174 patients with a total of 272 bifurcation lesions who were enrolled in this study. Each patient also underwent pre‐PCI IVUS in a major vessel (MV). SB was defined as ostium diameter of ≥1.5 mm measured by IVUS, and occluded SB was defined as a thrombolysis in myocardial infarction flow grade of ≤2 just after stent implantation. We defined the SB diameter ratio as ostial SB total diameter (media‐to‐media) divided by ostial SB luminal diameter (intima‐to‐intima).

Results

There were 52 SBs in the occluded group (19.1%). There were no significant differences in baseline characteristics between the SB occluded and non‐SB occluded groups. Logistic‐regression analysis revealed that the thickness of MV plaque on the bilateral sides of SB at the junction site and the SB diameter ratio were independent predictors of SB occlusion just after stent implantation.

Conclusions

In the IVUS observation, the MV plaque thickness at the junction site and the SB diameter ratio are predictors of acute SB occlusion just after single stent crossover. © 2015 Wiley Periodicals, Inc.
Achievable radiation reduction during pediatric cardiac catheterization: How low can we go?
Authors: Borik Sharon , Devadas Sunder , Mroczek Dariusz , Jin Lee Kyong , Chaturvedi Rajiv , Benson Lee N.
Published: May 2015

Objectives

To assess the effectiveness of radiation‐reduction measures implemented during pediatric catheterization, and provide data on the radiation doses for common interventional and diagnostic procedures, indexed to body weight.

Background

Ionizing radiation exposure must be minimized to “as low as reasonably achievable,” by instituting radiation‐limiting techniques and knowledge of expected radiation exposure.

Methods

Radiation‐reduction measures included pulsed‐fluoroscopy at 7.5 pulses/second (0.032–0.045 µGy/pulse), an air‐gap magnification technique for children <20 kg, operator awareness, and additional exposure reduction techniques through projection optimization. Radiation doses for procedures performed between 2007 through 2014 were retrospectively reviewed, including dose area product (DAP) and DAP/kg of body weight for 25 procedural types. Median doses were compared with those previously published from other large centers and multi‐institutional databases and assessed for changes over time.

Results

Reviewed were 5,196 cases, which included 2,819 interventional, 710 endomyocardial biopsies and 1,667 diagnostic studies, documenting a significant difference in exposure between various procedures and body weights. The absolute exposure was significantly greater in larger children (e.g., for ductal closure median DAP/kg: 17 µGy*m2/kg 10–20 kg children vs. 37 µGy*m2/kg for those >30 kg, P < 0.001). Dose exposure using radiation‐reduction techniques were the lowest reported in the literature for all procedure types compared (e.g. median DAP for pulmonary valvuloplasty 163 µGy*m2 vs. 405 to 1,230 µGy*m2 reported by 3 large centers). Reduction of fluoroscopy acquisition to 7.5 pulses/second nearly halved radiation exposure (P < 0.001).

Conclusions

Implementing a radiation dose reduction and awareness program can lead to documented reduction in exposure, across a variety of procedures performed by multiple operators. © 2015 Wiley Periodicals, Inc.
Outcomes after multivessel or culprit‐Vessel intervention for ST‐elevation myocardial infarction in patients with multivessel coronary disease: A Bayesian cross‐design meta‐analysis
Authors: Bittl John A. , Tamis‐Holland Jacqueline E. , Lang Christopher D. , He Yulei
Published: May 2015

Introduction

During primary percutaneous coronary intervention (PCI), patients with ST‐elevation myocardial infarction (STEMI) and multivessel coronary disease can undergo either multivessel intervention (MVI) or culprit‐vessel intervention (CVI) only.

Background

Randomized controlled trials (RCTs) support the use of MVI, but cohort studies support the use of CVI.

Methods

We developed Bayesian models that incorporated parameters for study type and study outcome after MVI or CVI.

Results

A total of 18 studies (4 RCTs, 3 matched cohort studies, and 11 unmatched observational studies) enrolled 48,398 patients with STEMI and multivessel CAD and reported outcomes after MVI or CVI‐only at the time of primary PCI. Using a Bayesian hierarchical model, we found that the point estimates replicated previously reported trends, but the wide Bayesian credible intervals (BCI) excluded any plausible mortality difference between MVI versus CVI in all three study types: RCTs (odds ratio [OR] 0.60, 95% BCI 0.31–1.20), matched cohort studies (OR 1.37, 95% BCI 0.86–2.24), or unmatched cohort studies (OR 1.16, 95% BCI 0.70–1.89). Both the global summary (OR 1.10, 95% BCI 0.74–1.51) and a sensitivity analysis that weighted the RCTs 1–5 times as much as observational studies revealed no credible advantage of one PCI strategy over the other (OR 1.05, 95% BCI 0.64–1.48).

Conclusions

Bayesian approaches contextualize the comparison of different strategies by study type and suggest that neither MVI nor CVI emerges as a preferred strategy in an analysis that accounts mortality differences. © 2015 Wiley Periodicals, Inc.
The wedding cake solution: A percutaneous correction of a form fruste superior sinus venosus atrial septal defect
Authors: Crystal Matthew A. , Vincent Julie A. , Gray William A.
Published: May 2015

We present the case of a patient with a superior sinus venosus defect (SSVD), with the atypical finding of an intact atrial septum and posterior atrial wall, which underwent percutaneous closure in the cardiac catheterization laboratory for repair. SSVDs are rare congenital cardiac anomalies, but when the anatomy is amenable to percutaneous strategies, a collaborative and creative approach can result in a safe and effective result. © 2015 Wiley Periodicals, Inc.
ChemInform Abstract: Two‐Dimensional Cu2Si Monolayer with Planar Hexacoordinate Copper and Silicon Bonding.
Authors: Yang Li‐Ming , Bacic Vladimir , Popov Ivan A. , Boldyrev Alexander I. , Heine Thomas , Frauenheim Thomas , Ganz Eric
Published: May 2015

A new Cu2Si two‐dimensional monolayer featuring planar hexacoordinate copper and planar hexacoordinate silicon is predicted on the basis of DFT calculations and molecular dynamic simulations.
ChemInform Abstract: Influence of the Oxygen Content in Obtaining Tunable and Strong Photoluminescence from Low‐Temperature Grown Silicon Oxycarbide Films.
Authors: Lin Zhenxu , Guo Yanqing , Song Chao , Song Jie , Wang Xiang , Zhang Yi , Huang Rui , Huang Xintang
Published: May 2015

Amorphous SiCxOy films are prepared by very high frequency plasma enhanced chemical vapor deposition at 150 °C using a gas mixture of SiH4, CH4, and O2 as the precursor.
ChemInform Abstract: Fe4I3O24H15: A Novel Semiconductor with High Performance in Photodegradation of Rhodamine B Dyes under Visible Light Irradiation.
Authors: Li Datang , Tang Jianting , Li Jing
Published: May 2015

UV/VIS diffuse reflectance spectroscopy indicates that the title compound is a semiconductor with a band gap of about 2.30 eV.
ChemInform Abstract: Mn2FeWO6: A New Ni3TeO6‐Type Polar and Magnetic Oxide.
Authors: Greenblatt Martha
Published: May 2015

Polycrystalline black Mn2FeWO6 is synthesized from a stoichiometric mixture of MnO, Fe2O3, and WO3 (multi‐anvil press, 8 GPa, 1673 K, 1 h) and characterized by powder XRD, TEM, XANES, second harmonic generation, magnetic, dielectric and polarization measurements, and DFT calculations.
ChemInform Abstract: The Phase Equilibria and Crystal Structure of the Phases in the Hf—Ti—P System.
Authors: Lomnytska Yaroslava , Dzevenko Mariya , Oliynyk Anton , Kushnir Ivanna , Toma Oksana
Published: May 2015

The new phosphide Hf5.35Ti8.65P8.93 exists in the title system at 1070 K.
ChemInform Abstract: Crystal Structure and Moessbauer Studies of the Isotypic Fe6‐Cluster Compounds RE15[Fe8C25], RE: Dy, Ho.
Authors: Davaasuren Bambar , Dashjav Enkhtsetseg , Kreiner Guido , Borrmann Horst , Weber Sven‐Ulf , Becker Klaus‐Dieter , Jochen Litterst Fred , Kniep Ruediger
Published: May 2015

The title compounds are prepared by arc melting of the elements followed by annealing (Ta ampules, 1373 K, 21 d).
ChemInform Abstract: Cytisine as a Scaffold for ortho‐Diphenylphosphinobenzenecarboxamide Ligands for Pd‐Catalyzed Asymmetric Allylic Alkylation.
Authors: Philipova Irena , Stavrakov Georgi , Vassilev Nikolay , Nikolova Rositsa , Shivachev Boris , Dimitrov Vladimir
Published: May 2015

Novel phosphino‐benzenecarboxamide ligands are synthesized starting from (‐)‐cytisine and applied in the Pd‐catalyzed asymmetric allylic alkylation of (E)‐1,3‐diphenyl‐2‐propenyl acetate.
ChemInform Abstract: Asymmetric Hydrogenation via Capture of Active Intermediates Generated from Aza‐Pinacol Rearrangement.
Authors: Yu Chang‐Bin , Huang Wen‐Xue , Shi Lei , Chen Mu‐Wang , Wu Bo , Zhou Yong‐Gui
Published: May 2015

A highly enantioselective Pd‐catalyzed hydrogenation of reactive intermediates generated by aza‐pinacol rearrangement of N‐sulfonyl aminoalcohols offers an efficient access to N‐cycloalkyl substituted sulfonamides with up to 98% e.e.
ChemInform Abstract: Enantioselective Cycloadditions of Vinyl Cyclopropanes and Nitroolefins for Functionally and Optically Enriched Nitrocyclopentanes.
Authors: Li Wen‐Ke , Liu Ze‐Shui , He Long , Kang Tai‐Ran , Liu Quan‐Zhong
Published: May 2015

The two diastereomers can be easily separated by column chromatography.
ChemInform Abstract: Organocatalyzed Asymmetric Aldol Reactions of Ketones and β,γ‐Unsaturated α‐Ketoesters and Phenylglyoxal Hydrates.
Authors: Konda Swapna , Guo Qun‐Sheng , Abe Manabu , Huang Huicai , Arman Hadi , Zhao John C.‐G.
Published: May 2015

Quinidine‐derived thiourea derivative (Ia) is an efficient catalyst for the asymmetric aldol reaction of β,γ‐unsaturated α‐ketoesters (II) with acetophenones (III), whilst similar catalyst (Ib) is successfully applied for the synthesis of 2‐hydroxy‐1,4‐diones (VII) via aldol reaction of arylglyoxal hydrates (V) with cycloalkanones (VI).
ChemInform Abstract: Divergent Regioselectivity in Photoredox‐Catalyzed Hydrofunctionalization Reactions of Unsaturated Amides and Thioamides.
Authors: Morse Peter D. , Nicewicz David A.
Published: May 2015

A mild and efficient method for the synthesis of novel oxazole, thiazoline, and thiazine derivatives is presented which operates under mild conditions.
ChemInform Abstract: Gold(I)‐Catalyzed 1,4‐ and/or 1,5‐Heteroaryl Migration Reactions Through Regiocontrolled Cyclizations.
Authors: Wang Chengyu , Xie Xin , Liu Jun , Liu Yuanhong , Li Yuxue
Published: May 2015

This reaction provides a concise access to stereodefined trisubstituted alkenes by endo cyclization with concomitant 1,5‐migration of the furanyl group in the presence of unactivated molecular sieves.
ChemInform Abstract: Synergistic Photocatalytic Aerobic Oxidation of Sulfides and Amines on TiO2 under Visible‐Light Irradiation.
Authors: Lang Xianjun , Leow Wan Ru , Zhao Jincai , Chen Xiaodong
Published: May 2015

TiO2 acts as a photocatalyst in the synergistic aerobic oxidation of aryl sulfides and benzylamines.
ChemInform Abstract: Enabling Catalytic Ketone Hydrogenation by Frustrated Lewis Pairs.
Authors: Mahdi Tayseer , Stephan Douglas W.
Published: May 2015

In this simple metal‐free procedure borane and ether behave as a frustrated Lewis pair to activate H2 and effect the reduction of ketones.
ChemInform Abstract: Synthesis of 4,4‐Difluoro‐1‐H‐pyrazole Derivatives.
Authors: Breen Jessica R. , Sandford Graham , Patel Bhairavi , Fray Jonathan
Published: May 2015

The reaction of 3,5‐dimethyl and 3‐phenyl‐5‐alkyl 1H‐pyrazoles with Selectfluor furnishes the corresponding 4‐monofluoro pyrazole derivatives, but fails for pyrazole systems bearing two electron withdrawing groups.
ChemInform Abstract: Ruthenium‐Catalyzed Reductive Amination Without an External Hydrogen Source.
Authors: Kolesnikov Pavel N. , Yagafarov Niyaz Z. , Usanov Dmitry L. , Maleev Victor I. , Chusov Denis
Published: May 2015

A wide range of amines is obtained using carbon monoxide as reductant.
ChemInform Abstract: Preparation and Catalytic Activity of BINOL‐Derived Silanediols.
Authors: Wieting Joshua M. , Fisher Thomas J. , Schafer Andrew G. , Visco Michael D. , Gallucci Judith C. , Mattson Anita E.
Published: May 2015

A series of enantiopure silanediols are derived from BINOL and applied as catalyst to the asymmetric N‐acyl Mannich reaction.
ChemInform Abstract: Mild Rhodium(III)‐Catalyzed C—H Allylation with 4‐Vinyl‐1,3‐dioxolan‐2‐ones: Direct and Stereoselective Synthesis of (E)‐Allylic Alcohols.
Authors: Zhang Shang‐Shi , Wu Jia‐Qiang , Lao Ye‐Xing , Liu Xu‐Ge , Liu Yao , Lv Wen‐Xin , Tan Dong‐Hang , Zeng Yao‐Fu , Wang Honggen
Published: May 2015

The scalable and operationally simple transformation does not require exclusion of air and moisture and tolerates a range of functional groups.
ChemInform Abstract: A New Organocatalytic Concept for Asymmetric α‐Alkylation of Aldehydes.
Authors: Caruana Lorenzo , Kniep Florian , Johansen Tore Kiilerich , Poulsen Pernille H. , Joergensen Karl Anker
Published: May 2015

Enamine‐activated aldehydes are added to p‐quinone methides to yield aldehydes with two contiguous stereocenters with good diastereo‐ and excellent enantioselectivity.
ChemInform Abstract: Mesoporous Silica MCM‐41 Supported N‐Heterocyclic Carbene‐Pd Complex for Heck and Sonogashira Coupling Reactions.
Authors: Sarkar Shaheen M. , Yusoff Mashitah Mohd , Rahman Md. Lutfor
Published: May 2015

A heterocyclic carbene‐Pd complex anchored onto mesoporous silica MCM‐41 exhibits excellent catalytic activity in Heck as well as Sonogashira coupling reactions under phosphine‐free conditions.
ChemInform Abstract: Copper‐Catalyzed 1,2‐Addition of α‐Carbonyl Iodides to Alkynes.
Authors: Xu Tao , Hu Xile
Published: May 2015

The title reaction of in situ generated α‐carbonyl iodides with terminal alkynes for the efficient α‐alkenylation of ketones provides β,γ‐iodoketones.
ChemInform Abstract: Copper(I)‐Catalyzed Enantioselective Synthesis of α‐Chiral Linear or Carbocyclic (E)‐(γ‐Alkoxyallyl)boronates.
Authors: Yamamoto Eiji , Takenouchi Yuta , Ozaki Taichi , Miya Takanori , Ito Hajime
Published: May 2015

The title reaction starts from allyl acetates bearing a variety of functional groups and proceeds with high E‐selectivity and excellent enantioselectivity.
ChemInform Abstract: Ambient Synthesis of Dienals via Triazole—Gold and Amine Catalysis Relay.
Authors: Motika Stephen E. , Wang Qiaoyi , Ye Xiaohan , Shi Xiaodong
Published: May 2015

Due to isomerization of the prepared dienals, the products are isolated after reduction of the carbonyl group.
ChemInform Abstract: CuSO4·5H2O‐H‐Phosphonate‐Catalyzed Intermolecular C—S Bond Formation: Synthesis of (E)‐Vinyl Alkylsulfones from Alkynes and DMSO.
Authors: Chen Xiao‐Lan , et al.
Published: May 2015

This protocol provides an alternative approach to various vinyl sulfones, with the advantages of cheap catalysts, readily available starting materials, operational simplicity and high stereo‐ and regioselectivity.
ChemInform Abstract: Direct Catalytic Cross‐Coupling of Alkenyllithium Compounds.
Authors: Hornillos Valentin , Giannerini Massimo , Vila Carlos , Fananas‐Mastral Martin , Feringa Ben L.
Published: May 2015

A catalytic method for the direct cross‐coupling of various alkenyllithium compounds with aryl and alkenyl halides is described.
ChemInform Abstract: Transition‐Metal‐Free, Potassium tert‐Butoxide/Dimethyl Sulfoxide Mediated Amination Between Tertiary Amines and Aryl Halides.
Authors: Huang Pei , He Bang‐Yue , Wang Hui‐Min , Lu Jian‐Mei
Published: May 2015

The C—N coupling of aromatic and tertiary amines with aryl halides is achieved.
ChemInform Abstract: Improved Sommelet Reaction Catalyzed by Lanthanum Triflate.
Authors: Xu Wenhao , Su Weike
Published: May 2015

A novel procedure for carrying out the Sommelet reaction under eco‐friendly conditions is developed.
ChemInform Abstract: General Base‐Tuned Unorthodox Synthesis of Amides and Ketoesters with Water.
Authors: Khamarui Saikat , Maiti Rituparna , Maiti Dilip K.
Published: May 2015

The base‐tuned preparation of a new λ3‐hypervalent iodane species from inexpensive PhI(OAc)2 is reported.
ChemInform Abstract: A Practical Way to Prepare Isobutyronitrile Amides Through Reactions Between Carboxylic Acids and Azobisisobutyronitrile.
Authors: Rong Guangwei , Liu Defu , Yan Hong , Chen Jie , Zheng Yang , Zhang Guoqi , Mao Jincheng
Published: May 2015

Isobutyronitrile amides are efficiently synthesized via a simple one‐step pathway without any catalysts or additives.
ChemInform Abstract: Synthesis of Isonitriles from N‐Substituted Formamides Using Triphenylphosphine and Iodine.
Authors: Wang Xia , Wang Qing‐Gang , Luo Qun‐Li
Published: May 2015

A practical method for a convenient access to isonitriles by using inexpensive and readily available reagents of low toxicity is presented.
ChemInform Abstract: An Enantioselective Approach to the Preparation of Chiral Sulfones by Ir‐Catalyzed Asymmetric Hydrogenation.
Authors: Peters Byron K. , Zhou Taigang , Rujirawanich Janjira , Cadu Alban , Singh Thishana , Rabten Wangchuk , Kerdphon Sutthichat , Andersson Pher G.
Published: May 2015

The scalable hydrogenation of vinylic, allylic, and homoallylic sulfones is investigated with the conversion of the E‐isomers being faster than the one of Z‐isomers while delivering opposite enantiomers.
ChemInform Abstract: Symmetric Diarylsulfoxides as Asymmetric Sulfinylating Reagents for Dialkylmagnesium Compounds.
Authors: Ruppenthal Simon , Brueckner Reinhard
Published: May 2015

The Mg reactants are complexed with the optically active agent LBN prior to the addition of a diarylsulfoxide.
ChemInform Abstract: Palladium‐Catalyzed ortho‐Arylation of Benzoic Acid Derivatives via C—H Bond Activation Using an Aminoacetic Acid Bidentate Directing Group.
Authors: Zhou Xiaomeng , Wang Qing , Zhao Weihua , Xu Songsong , Zhang Wei , Chen Junmin
Published: May 2015

This improved protocol for the ortho‐arylation of benzoic acids with aryl iodides utilizes an aminoacetic acid‐based N,O‐coordination strategy leading to mono‐arylation of benzoyl aminoacetic acid substrates.
ChemInform Abstract: Facile and Diastereoselective Synthesis of 3,2′‐Spiropyrrolidine‐oxindoles Derivatives, Their Molecular Docking and Antiproliferative Activities.
Authors: Kathirvelan D. , Haribabu J. , Reddy B. S. R. , Balachandran C. , Duraipandiyan V.
Published: May 2015

Title compounds (IV) and (VI) are prepared through 1,3‐dipolar cycloaddition of an azomethin ylide formed in situ from isatin (III) and amino acids (II) or (V) with dipolarophile (I).
ChemInform Abstract: Diastereoselective Synthesis of Spirocyclic Dihydrofurans and 1‐Oxaspiro[4.5]decan‐6‐one Derivatives from Norbornyl α‐Diketones.
Authors: Mahadevegowda Surendra H. , Khan Faiz Ahmed
Published: May 2015

Various spirocyclic dihydrofuran structures are prepared in a diastereoselective manner following the sequence shown for (IV) and (VII).
ChemInform Abstract: Synthesis of Oxaspiranic Compounds Through [3 + 2] Annulation of Cyclopropenones and Donor—Acceptor Cyclopropanes
Authors: Rivero Alexandra R. , Fernandez Israel , Ramirez de Arellano Carmen , Sierra Miguel A.
Published: May 2015

The reaction between equimolar ratios of substrates allows the direct access to the title compounds.
ChemInform Abstract: Stereoselective Radical C—H Alkylation with Acceptor/Acceptor‐Substituted Diazoreagents via Co(II)‐Based Metalloradical Catalysis.
Authors: Cui Xin , Xu Xue , Jin Li‐Mei , Wojtas Lukasz , Zhang X. Peter
Published: May 2015

A new chiral amidoporphyrin derivative acts as a catalyst in the intramolecular 1,5‐C—H alkylation of α‐methoxycarbonyl α‐diazosulfones of type (I) to give chiral sulfolane derivatives of type (II) in high yields with excellent diastereoselectivities and enantioselectivities.
ChemInform Abstract: Bridging Homogeneous and Heterogeneous Catalysis with CAN·SiO2 as a Solid Catalyst for Four‐Component Reactions for the Synthesis of Tetrasubstituted Pyrroles.
Authors: Atar Amol B. , Kim Jong Su , Lim Kwon Taek , Jeong Yeon Tae
Published: May 2015

Title compounds [(V) and (IX)] are simply and efficiently synthesized by an economical and environmentally friendly one‐pot procedure.
ChemInform Abstract: Quick and Easy Access to N‐Mannich Bases of 1‐Isoindolinones by Catalytic Electroactivation of Primary and Secondary Amines and Tandem Reaction with 2‐Formylbenzonitriles.
Authors: Palombi Laura , Di Mola Antonia , Massa Antonio
Published: May 2015

Title compounds are synthesized under simple galvanostatic conditions without any metal or basic catalyst.
ChemInform Abstract: Rapid α‐Amination of N‐Substituted Indoles by Using DBU‐Activated N‐Haloimides as Nitrogen Sources.
Authors: Li Yanru , Zhang Luyan , Yuan Haiyan , Liang Fushun , Zhang Jingping
Published: May 2015

The rapid and efficient reaction tolerates variously substituted indole‐derivatives which are aminated using N‐bromosuccinimide, N‐bromophthalimide, and N‐bromosaccharin.
ChemInform Abstract: 2‐Iodoisatogens: Versatile Intermediates for the Synthesis of Nitrogen Heterocycles.
Authors: Maduli Elvis J. M. , Edeson Steven J. , Swanson Stephen , Procopiou Panayiotis A. , Harrity Joseph P. A.
Published: May 2015

The Cu(I)‐promoted cyclization of 2‐nitrophenylhaloacetylenes to 2‐iodoisatogens is described.
ChemInform Abstract: “Transition‐Metal‐Free” Synthesis of Carbazoles by Photostimulated Reactions of 2′‐Halo[1,1′‐biphenyl]‐2‐amines.
Authors: Guerra Walter D. , Rossi Roberto A. , Pierini Adriana B. , Barolo Silvia M.
Published: May 2015

The starting materials are generally prepared following the approaches shown for (IIIa) and (XIII).
ChemInform Abstract: Pd‐Catalyzed Dehydrogenative Aryl—Aryl Bond Formation via Double C(sp2)—H Bond Activation: Efficient Synthesis of [3,4]‐Fused Oxindoles.
Authors: Bunescu Ala , Piou Tiffany , Wang Qian , Zhu Jieping
Published: May 2015

Starting from easily available 2‐bromo anilides a domino reaction involving two cyclization reactions is described which allows for the efficient construction of tetracyclic strained [3,4]‐fused oxindoles.
ChemInform Abstract: Asymmetric Lewis Acid Catalysis Directed by Octahedral Rhodium Centrochirality.
Authors: Wang Chuanyong , Chen Liang‐An , Huo Haohua , Shen Xiaodong , Harms Klaus , Gong Lei , Meggers Eric
Published: May 2015

The catalytic activities of the rhodium‐based asymmetric catalysts Δ‐ and Λ‐RBO are compared to the activities of the corresponding iridium catalysts.
ChemInform Abstract: Synthesis of Azoimidazolium Dyes with Nitrous Oxide.
Authors: Tskhovrebov Alexander G. , Naested Lara C. E. , Solari Euro , Scopelliti Rosario , Severin Kay
Published: May 2015

AlCl3‐mediated coupling of a variety of arenes with N2O‐adducts of NHC‐carbenes offers a synthetic route to novel azoimidazolium dyes (IV) and (VI).
ChemInform Abstract: Synthesis of 2‐Amino‐1,3,4‐oxadiazoles and 2‐Amino‐1,3,4‐thiadiazoles via Sequential Condensation and I2‐Mediated Oxidative C—O/C—S Bond Formation.
Authors: Niu Pengfei , Kang Jinfeng , Tian Xianhai , Song Lina , Liu Hongxu , Wu Jie , Yu Wenquan , Chang Junbiao
Published: May 2015

The transition metal free sequence allows a facile and generally high‐yielding approach to the title heterocycles with a use of aromatic, aliphatic, and cinnamic aldehyde reactants.
ChemInform Abstract: Rh(III)‐Catalyzed Oxidative C—H Bond Arylation with Hydroquinones: Sustainable Synthesis of Dibenzo[b,d]pyran‐6‐ones and Benzo[d]naphtho[1,2‐b]pyran‐6‐ones.
Authors: Yang Wei , Wang Shan , Zhang Qian , Liu Qun , Xu Xianxiu
Published: May 2015

The arylation—lactonization tandem reaction of N‐methoxyarylamides with hydroquinone (II) provides access to a series of dibenzopyran‐6‐ones (III) and analogues (V), (XIII), and (XV).
ChemInform Abstract: Ionic Liquid Catalyzed Synthesis of 2‐(Indole‐3‐yl)‐thiochroman‐4‐ones and Their Novel Antifungal Activities.
Authors: Song Ya‐Li , Wu Fan , Zhang Chao‐Chao , Liang Guo‐Chao , Zhou Guan , Yu Jiao‐Jiao
Published: May 2015

15 Title compounds are prepared and screened for their antifungal activities.
ChemInform Abstract: Efficient 2‐Sulfolmethyl Quinoline Formation from 2‐Methylquinolines and Sodium Sulfinates under Transition‐Metal Free Conditions.
Authors: Xiao Fuhong , Chen Shuqing , Chen Ya , Huang Huawen , Deng Guo‐Jun
Published: May 2015

A series of 2‐sulfonylmethyl quinolines (III) and (V) is readily prepared by a sulfonylation of corresponding 2‐methylquinolines with sodium sulfinates in the presence of tBuOOH and KI.
ChemInform Abstract: Diversity‐Oriented Synthesis of Intensively Blue Emissive 3‐Hydroxyisoquinolines by Sequential Ugi Four‐Component Reaction/Reductive Heck Cyclization.
Authors: Moni Lisa , Denissen Melanie , Valentini Gianluca , Mueller Thomas J. J. , Riva Renata
Published: May 2015

A convergent approach to highly functionalized 3‐hydroxyisoquinolines is reported.
ChemInform Abstract: 3‐Methyl‐1‐sulfoimidazolium Ionic Liquids as Recyclable Medium for Efficient Synthesis of Quinoline Derivatives by Friedlaender Annulation.
Authors: Sarma Parishmita , Dutta Arup Kumar , Gogoi Pinky , Sarma Bipul , Borah Ruli
Published: May 2015

Various quinoline derivatives are obtained under solvent‐free reaction conditions using the title ionic liquids as reaction medium.
ChemInform Abstract: Stereoselective Lewis Base Catalyzed Formal 1,3‐Dipolar Cycloaddition of Azomethine Imines with Mixed Anhydrides.
Authors: Hesping Lena , Biswas Anup , Daniliuc Constantin G. , Mueck‐Lichtenfeld Christian , Studer Armido
Published: May 2015

Azomethine imines generated in situ from (II) react with esters generated in situ from 2‐phenylacetic acid derivatives (I) and benzoyl chloride in a dipolar cycloaddition reaction to afford tricyclic heterocycles of type (III) or (VI) with high diastereoselectivity and enantioselectivity.
ChemInform Abstract: Multicomponent Strategy to Indeno[2,1‐c]pyridine and Hydroisoquinoline Derivatives Through Cleavage of Carbon—Carbon Bond.
Authors: Feng Xian , Wang Jian‐Jun , Xun Zhan , Huang Zhi‐Bin , Shi Da‐Qing
Published: May 2015

A three‐component domino reaction is presented which allows the preparation of the heterocyclic scaffolds under transition metal free conditions A).
ChemInform Abstract: An Efficient Synthesis of 1,5‐Benzodiazepines Catalyzed by Bismuth Nitrate.
Authors: Bhattacharya Asish K. , Dange Santoshkumar S. , Polanki Innaiah K. , Chand Hemender R.
Published: May 2015

An efficient and convenient method for the synthesis of biologically active benzodiazepine derivatives via Bi‐catalyzed condensation reactions of o‐phenylenediamines with ketones at room temperature or microwave irradiation condition is given.
ChemInform Abstract: Alkynylboranes: A Practical Approach by Zinc‐Catalyzed Dehydrogenative Coupling of Terminal Alkynes with 1,8‐Naphthalenediaminatoborane.
Authors: Tsuchimoto Teruhisa , Utsugi Hirokazu , Sugiura Tetsuya , Horio Shin
Published: May 2015

Alkynylboranes [(III) and (VII)] are synthesized by title reaction.
ChemInform Abstract: 9‐Silafluorenes via Base‐Promoted Homolytic Aromatic Substitution (BHAS) — The Electron as a Catalyst.
Authors: Leifert Dirk , Studer Armido
Published: May 2015

The reaction proceeds efficiently for diphenyl substituted silanes, but not for dialkyl substituted silanes.
ChemInform Abstract: Enantioselective Synthesis of Arylglycine Derivatives by Direct C—H Oxidative Cross‐Coupling.
Authors: Wei Xiao‐Hong , Wang Gang‐Wei , Yang Shang‐Dong
Published: May 2015

This oxidative arylation is suitable for a variety of α‐amino acid derivatives, e.g. esters and amides including peptides.
ChemInform Abstract: (+)‐ and (‐)‐Petromyroxols: Antipodal Tetrahydrofurandiols from Larval Sea Lamprey (Petromyzon marinus L.) that Elicit Enantioselective Olfactory Responses.
Authors: Li Ke , Huertas Mar , Brant Cory , Chung‐Davidson Yu‐Wen , Bussy Ugo , Hoye Thomas R. , Li Weiming
Published: May 2015

Racemic petromyroxol (I) is isolated and chromatographically resolved.
ChemInform Abstract: Spirangien Derivatives from the Myxobacterium Sorangium cellulosum: Isolation, Structure Elucidation, and Biological Activity.
Authors: Bruns Nicole , Collisi Wera , Bernecker Steffen , Stadler Marc , Richter Christian , Schwalbe Harald , Kalesse Markus
Published: May 2015

In addition to the known spirangiens A (Ia) and B (Ib), eleven new analogues G‐Q are isolated.
ChemInform Abstract: Persistent Luminescent and Photocatalytic Properties of ZnxGa2O3+x (0.8 ≤ x ≤ 1) Phosphors.
Authors: Li Darong , Wang Yinhai , Xu Ke , Zhao Hui , Hu Zhengfa
Published: May 2015

The title phosphors (x = 1, 0.95, 0.9, 0.85, 0.8) are prepared by stoichiometric solid state reactions of ZnO and Ga2O3 (corundum crucible, 1300 °C, 5 h).
ChemInform Abstract: Microstructural Design of New High Conductivity — High Strength Cu‐Based Alloy.
Authors: Gorsse S. , Ouvrard B. , Goune M. , Poulon‐Quintin A.
Published: May 2015

The evolution of microstructural, electrical, and mechanical properties of Cu—Mg alloys with different content of Mg (4.1 at.%, 8.1 at.%, 23.1 at.%) are investigated.
ChemInform Abstract: Recent Progress in Preparation and Lithium‐Ion Storage Properties of TiO2 Mesocrystals
Authors: Hong Zhensheng , Wei Mingdeng
Published: May 2015

Review: 40 refs.
ChemInform Abstract: Aqueous Alteration of Potassium‐Bearing Aluminosilicate Minerals: From Mechanism to Processing
Authors: Skorina Taisiya , Allanore Antoine
Published: May 2015

Review: 144 refs.
ChemInform Abstract: Recent Advances in Synthesis of Reshaped Fe and Ni Particles at the Tips of Carbon Nanofibers and Their Catalytic Applications
Authors: Duan Xuezhi , Ji Jian , Qian Gang , Zhou Xinggui , Chen De
Published: May 2015

Review: 90 refs.
ChemInform Abstract: SnO2: A Comprehensive Review on Structures and Gas Sensors
Authors: Das Soumen , Jayaraman V.
Published: May 2015

Review: 886 refs.
ChemInform Abstract: Palladium‐Catalyzed α‐Arylation of Carbonyls in the de novo Synthesis of Aromatic Heterocycles
Authors: Potukuchi Harish K. , Spork Anatol P. , Donohoe Timothy J.
Published: May 2015

Review: [12 refs.
ChemInform Abstract: The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: From Ebenaceae to Solanaceae
Authors: Yong Joseph N. , Ntie‐Kang Fidele
Published: May 2015

Review: 100 refs.
ChemInform Abstract: Synthesis of Triazole, Indole, and Five or Six‐Membered Saturated Heterocyclic Compounds
Authors: Sajiki Hironao , Monguchi Yasunari , Sawama Yoshinari
Published: May 2015

Review: [61 refs.
ChemInform Abstract: Pillar[n]arenes and Other Cavitands: Aspects of Complex Thermodynamics
Authors: Park Chiyoung , Kim Kyoung Taek
Published: May 2015

Review: 67 refs.
ChemInform Abstract: Pillarene‐Involved Metallic Supramolecular Nanostructures
Authors: Zhang Chang‐Wei , Chen Li‐Jun , Yang Hai‐Bo
Published: May 2015

Review: 68 refs.
ChemInform Abstract: Magnetically Recoverable Catalysts with Dendritic Ligands for Enhanced Catalysis and Easy Separation
Authors: Bronstein Lyudmila M.
Published: May 2015

Review: 8 refs.
ChemInform Abstract: Directed Lithiation and Substitution of Pyridine Derivatives
Authors: El‐Hiti Gamal A. , Smith Keith , Hegazy Amany S.
Published: May 2015

Review: 72 refs.
ChemInform Abstract: Chemistry of Macrocyclic β‐Lactam: An Overveiw
Authors: Narayan Pati Hari , Bhaskar Vangala Vijaya , Rachappa Maddani Mahagundappa , Mohan Hindupur Rama
Published: May 2015

Review: [44 refs.
ChemInform Abstract: Catalytic Properties of Unsupported Palladium Nanoparticle Surfaces Capped with Small Organic Ligands
Authors: Gavia Diego J. , Shon Young‐Seok
Published: May 2015

Review: 105 refs.
ChemInform Abstract: Enantioselective Helicene Synthesis by Rhodium‐Catalyzed [2 + 2 + 2] Cycloadditions
Authors: Tanaka Ken , Kimura Yuki , Murayama Koichi
Published: May 2015

Review: [26 refs.
ChemInform Abstract: Hydrindacenes as Versatile Supramolecular Scaffolds
Authors: Kawai Hidetoshi
Published: May 2015

Review: [35 refs.
ChemInform Abstract: Asymmetric Catalysis with Short‐Chain Peptides
Authors: Lewandowski Bartosz , Wennemers Helma
Published: May 2015

Review: 43 refs.
ChemInform Abstract: Modification of Purine and Pyrimidine Nucleosides by Direct C—H Bond Activation
Authors: Liang Yong , Wnuk Stanislaw F.
Published: May 2015

Review: 81 refs.
ChemInform Abstract: Total Synthesis of Steroids and Heterosteroids from BISTRO
Authors: Ibrahim‐Ouali Malika
Published: May 2015

Review: 134 refs.
ChemInform Abstract: Recent Advances in Metal Free‐ and Late Transition Metal‐Catalyzed Hydroamination of Unactivated Alkenes
Authors: Bernoud Elise , Lepori Clement , Mellah Mohamed , Schulz Emmanuelle , Hannedouche Jerome
Published: May 2015

Review: 154 refs.
ChemInform Abstract: Recent Developments in the Synthesis of Imidazo[1,2‐a]pyridines
Authors: Pericherla Kasiviswanadharaju , Kaswan Pinku , Pandey Khima , Kumar Anil
Published: May 2015

Review: [151 refs.
ChemInform Abstract: Challenges in the Substitution of Terminal C—C Double Bonds with Tertiary Alkyl Groups
Authors: Nishikata Takashi , Ishikawa Shingo
Published: May 2015

Review: [23 refs.
ChemInform Abstract: Organic and Hybrid Molecular Systems
Authors: Nifantiev Nikolay E. , et al.
Published: May 2015

Review: [68 refs.
ChemInform Abstract: Total Synthesis of Natural and Pharmaceutical Products Powered by Organocatalytic Reactions
Authors: Sun Bing‐Feng
Published: May 2015

Review: [21 refs.
ChemInform Abstract: Mechanochemical Synthesis of Advanced Nanomaterials for Catalytic Applications
Authors: Xu Chunping , De Sudipta , Balu Alina M. , Ojeda Manuel , Luque Rafael
Published: May 2015

Review: [92 refs.
ChemInform Abstract: Progress and Developments in the Turbo Grignard Reagent i‐PrMgCl·LiCl: A Ten‐Year Journey
Authors: Li‐Yuan Bao Robert , Zhao Rong , Shi Lei
Published: May 2015

Review: [57 refs.
ChemInform Abstract: Sustainable Metal‐Based Catalysts for the Synthesis of Cyclic Carbonates Containing Five‐Membered Rings
Authors: Comerford James W. , Ingram Ian D. V. , North Michael , Wu Xiao
Published: May 2015

Review: [107 refs.
ChemInform Abstract: Giant Magnetotransmission and Magnetoreflection in Ferromagnetic Materials
Authors: Telegin A. V. , Sukhorukov Yu. P. , Loshkareva N. N. , Mostovshchikova E. V. , Bebenin N. G. , Gan'shina E. A. , Granovsky A. B.
Published: May 2015

Review: such as chromium chalcogenide spinel, manganites with perovskite structure, anthin‐film metallic nanostructures; 64 refs.
ChemInform Abstract: Selected Hybrid Natural Products as Tubulin Modulators
Authors: Dasari Bhanudas , Jimmidi Ravikumar , Arya Prabhat
Published: May 2015

Review: [67 refs.
ChemInform Abstract: Advances in the Discovery of Novel Antimicrobials Targeting the Assembly of Bacterial Cell Division Protein FtsZ
Authors: Li Xin , Ma Shutao
Published: May 2015

Review: 139 refs.
ChemInform Abstract: Bio‐Derived Materials as a Green Route for Precious & Critical Metal Recovery and Re‐Use
Authors: Dodson Jennifer R. , Parker Helen L. , Munoz Garcia Andrea , Hicken Alexandra , Asemave Kaana , Farmer Thomas J. , He He , Clark James H. , Hunt Andrew J.
Published: May 2015

Review: 217 refs.
Geometric Ergodicity for Piecewise Contracting Processes with Applications for Tropical Stochastic Lattice Models
Authors: Majda Andrew J. , Tong Xin T.
Published: May 2015

Stochastic lattice models are increasingly prominent as a way to capture highly intermittent unresolved features of moist tropical convection in climate science and as continuum mesoscopic models in material science. Stochastic lattice models consist of suitably discretized continuum partial differential equations interacting with Markov jump processes at each lattice site with transition rates depending on the local value of the continuum equation; they are a special case of piecewise deterministic Markov processes but often have an infinite state space and unbounded transition rates. Here a general theorem on geometric ergodicity for piecewise deterministic contracting processes is developed with full generality to apply to stochastic lattice models. A highly nontrivial application to the stochastic skeleton model for the Madden‐Julian oscillation (Thual et al., 2013) is developed here where there is an infinite state space with unbounded and also degenerate transition rates. Geometric ergodicity for the stochastic skeleton model guarantees exponential convergence to a unique invariant measure that defines the statistical tropical climate of the model. Another application of the general framework is developed here for stochastic lattice models designed to capture intermittent fluctuation in the simplest tropical climate models. Other straightforward applications to models motivated by material science are mentioned briefly here. © 2016 Wiley Periodicals, Inc.
An efficient RFID anticollision algorithm using early adjustment of frame length
Authors: Chen Wen‐Tzu
Published: May 2015

This paper proposes a radio frequency identification (RFID) anticollision algorithm to enhance the read performance of the EPCglobal UHF Class‐1 Generation‐2 standard. Our algorithm is based on the mechanism of early adjustment of frame length, as well as dynamic framed slotted ALOHA. To reduce computation complexity, the proposed algorithm adopts a simple rule for a reader to determine when and how the early adjustment starts. Furthermore, the proposed method resorts to at most three examinations of whether the early adjustment should start in each read round. As compared with the algorithms of examining at every time slot, the proposed method can significantly reduce the number of examinations. The normalized throughput of our method can reach a value of up to 34.6%. The advantage of low computation complexity comes at the expense of only 1.4% degradation of throughput. Therefore, it is suitable for most RFID readers built with a capability‐limited microprocessor. Copyright © 2015 John Wiley & Sons, Ltd.
The uFLIP benchmark revisited for evaluating SSDs
Authors: Kang Yoonsuk , Jo Yong‐Yeon , Cha Jaehhyuk , Kim Sang‐Wook , Shin Young Kyun
Published: May 2015

Solid‐state drives (SSDs) provide higher bandwidth and lower access latency than hard disk drives (HDDs) and thus have been rapidly replacing HDDs. SSD manufacturers, which produce different types of SSDs, do not open their SSD architecture and control firmware in detail. To find the best SSD for a given application, it is necessary to compare and analyze the performances of different kinds of SSDs. A benchmark is widely used to analyze the storage devices performance. However, most existing benchmarks are mainly targeted for HDDs. The uFLIP (understanding Flash IO Patterns) is a benchmark proposed to consider flash devices' characteristics. In this paper, we first exploit the uFLIP benchmark to analyze and to evaluate the performances of different types of SSDs. Through extensive experiments, we have identified common SSD characteristics: (1) the input/output (IO) size and queue depth affect the parallelism that is an inherent characteristic in SSDs; (2) the size of SSDs access space considerably affects the SSDs performance. Then, via a series of experiments, we verify whether the uFLIP benchmark could correctly characterize applications by its micro‐benchmarks. The results reveal that the performance of the uFLIP micro‐benchmarks, produced to have features similar to that of a target application, is quite different from the performance of the target application. Copyright © 2015 John Wiley & Sons, Ltd.
Functional analysis of Hairy genes in Xenopus neural crest initial specification and cell migration
Authors: Vega‐López Guillermo A. , Bonano Marcela , Tríbulo Celeste , Fernández Juan P. , Agüero Tristán H. , Aybar Manuel J.
Published: May 2015

Background: Neural crest formation is one of the fundamental processes in the early stages of embryonic development in vertebrates. This transient and multipotent embryonic cell population is able to generate a variety of tissues and cell types in the adult body. hairy genes are transcription factors that contain a basic helix–loop–helix domain which binds to DNA. In Xenopus three hairy genes are known: hairy1, hairy2a, and hairy2b. The requirement of hairy genes was explored in early neural crest development although the late requirements of these genes during neural crest maintenance, migration and derivatives formation are still unknown. Results: In this work, we extended the analysis of Xenopus hairy genes expression patterns and described new domains of expression. Functional analysis showed that hairy genes are required for the induction and migration of the neural crest and for the control of apoptosis. Moreover, we showed that hairy genes function as transcriptional repressors and that they are down‐regulated by bone morphogenetic protein‐Smad signaling and positively regulated by the Notch/Delta‐Su(h) pathway. Conclusions: Our results indicate that hairy genes have a functional equivalence between them and that they are required for multiple processes during neural crest development. Developmental Dynamics 244:988–1013, 2015. © 2015 Wiley Periodicals, Inc.
Generation of a tamoxifen inducible Tnnt2MerCreMer knock‐in mouse model for cardiac studies
Authors: Yan Jianyun , Sultana Nishat , Zhang Lu , Park David S. , Shekhar Akshay , Hu Jun , Bu Lei , Cai Chen‐Leng
Published: May 2015

Tnnt2, encoding thin‐filament sarcomeric protein cardiac troponin T, plays critical roles in heart development and function in mammals. To develop an inducible genetic deletion strategy in myocardial cells, we generated a new Tnnt2:MerCreMer (Tnnt2MerCreMer/+) knock‐in mouse. Rosa26 reporter lines were used to examine the specificity and efficiency of the inducible Cre recombinase. We found that Cre was specifically and robustly expressed in the cardiomyocytes at embryonic and adult stages following tamoxifen induction. The knock‐in allele on Tnnt2 locus does not impact cardiac function. These results suggest that this new Tnnt2MerCreMer/+ mouse could be applied towards the temporal genetic deletion of genes of interests in cardiomyocytes with Cre‐LoxP technology. The Tnnt2MerCreMer/+ mouse model also provides a useful tool to trace myocardial lineage during development and repair after cardiac injury. genesis 53:377–386, 2015. © 2015 Wiley Periodicals, Inc.