bluuebunny/crossref_metadata_2025 huggingface dataset:
Gaya Hidup Hedonis Ditinjau Dari Kecerdasan Finansial Mahasiswa Di Kota Madiun
Authors: Dwi Nila Andriani Novita Erliana Sari,
Published: October 2020

This study aims to determine the hedonic lifestyle of students in terms of financial intelligence. Hedonic lifestyles are the patterns of life of people who rely on pleasure. Financial intelligence is a person's ability to manage finances. It is assumed that student financial intelligence influences the hedonic style of students. This research is quantitative research. The research sample was all students in Madiun who were still actively studying. This study was tested with SPSS. 17 with simple linear regression analysis. The results of this study are hedonic lifestyles not influenced by financial literacy. Conclusions can be drawn from this study, although student financial intelligence can be said to be good, but with regard to lifestyle, students tend to choose what they enjoy for their lives.
Pengaruh Model Pembelajaran Kooperatif Tipe Gallery Walk terhadap Hasil Belajar Pada Pelajaran Ekonomi Kelas X di SMA Negeri 1 Perbaungan
Authors: Darwin Bangun Yuni Mariani Manik,
Published: October 2020

This study aims to determine the effect of cooperative learning gallery walk type on learning outcomes of class X1 students in SMA Negeri 1 Perbaungan as well as an overview of student learning outcomes after the application of the learning model. This study used a Pre-Experimental Research Design The one Pretest-posttest Design group with a population of all students in class X1 Perbaungan 1 High School, amounting to 30 students. Because the population is relatively small so that samples are taken as much as 100% of the population, the number of samples in this study are 30 students (One Experimental Class). Data collection is done by using questionnaires, tests, observations, and documentation. The data analysis technique used is descriptive statistical analysis and inferential statistical analysis. The results showed that the walk gallery type cooperative learning model had a correlation of 0.782 in the medium category with a simple regression analysis equation Y = -12.507 +1.641X. The results of hypothesis testing with SPSS obtained tcount = 6.640 and ttable of 2.048 with a calculated value abel t table with a value of 6.640 ³2.048 with a significance value of 0.000 so H1 is accepted and H0 is rejected, this indicates that the influence of the gallery walk type cooperative learning model on results studying class X1 Negeri 1 Perbaungan students. The magnitude of the contribution of the influence of the learning model is 61.2 percent, while 38.8 percent is influenced by other factors that have not been studied in this study.
Analisis Faktor Eksternal terhadap Perilaku Belajar Siswa SMA Patra Dharma Kota Balikpapan
Authors: Yuliani Tutik
Published: October 2020

This study aims to determine the effect of family environment and peer interaction on the learning behavior of XI SMA Patra Dharma Balikpapan students. Samples were obtained by means of random or random sampling techniques, with a sample of 95 students. How to collect data in this study by distributing questionnaires to class XI students of Patra Dharma High School students. To prove the hypothesis in this study by using t test and F test. The results of this study indicate that partially family environment, peer interaction affects the learning behavior of class XI students of Patra Dharma High School Balikpapan, this is shown by looking at the value of t count 2.223> t table 1,660 for family environment variables and t count 2,946> t table 1,660 for peer interaction. Whereas simultaneously the family environment, peer interaction affects the learning behavior of XI Patra Dharma Balikpapan class XI students, this is indicated by the calculated F value of 9.204 greater than Ftable = 3,098.
Pengaruh Struktur Kepemilikan Terhadap Nilai Perusahaan Dengan Profitabilitas Sebagai Variabel Intervening Studi Pada Sektor Property dan Real Estate
Authors: Luky Retno Sari Sutrisno,
Published: October 2020

This study aims to investigate the effect of ownership on firm value with profitability as an intervening variable. The dependent variable used is PBV. While the independent variables used are managerial ownership and institutional ownership. The intervening variable used is ROA. The data in this study used an annual report from 18 property and real estate companies listed on the Indonesia Stock Exchange in 2014 to 2018. The data collection technique used purposive sampling technique obtained from the web www.idx.co.id and each website from the sample company. Data processing uses panel data regression and the results reveal that managerial ownership and institutional ownership have no effect on firm value. While profitability (ROA) is able to mediate institutional ownership of firm value. But profitability (ROA) is not able to mediate managerial ownership of firm value.
Havalimanlarının Bulanık DEMATEL ve MABAC yöntemleri ile sıralanması
Authors: ÖZDAĞOĞLU Aşkın , KELEŞ Murat Kemal , IŞILDAK Barış
Published: October 2020

Havayolu ulaşımı, diğer ulaşım alternatiflerine göre hızlı, güvenilir ve konforlu olduğu için insanlar tarafından gün geçtikçe daha çok tercih edilmektedir. Ülkemizde havayolu ile ulaşımın yaygınlaşmasına paralel olarak havalimanı sayısında artış olmuş, mevcut havalimanlarının kapasiteleri genişletilmiştir. Havayolu ulaşımına talebin artmasıyla havalimanlarının hizmetleri ve performansları da önemli hale gelmiştir. Bu çalışmada, Türkiye’de aktif olarak faaliyet gösteren 52 adet havalimanının performansları Çok Kriterli Karar Verme Yöntemleri kullanılarak değerlendirilmiştir. Çalışmada, Devlet Hava Meydanları İşletmesi’nin havalimanlarına ilişkin 2019 yılına ait verileri analiz edilmiştir. Havalimanlarının performanslarının değerlendirilmesinde; havalimanına inen ve kalkan “toplam uçak sayısı”, havalimanını kullanarak seyahat eden “yolcu sayısı”, havalimanını kullanan “ticari uçak sayısı”, havalimanında işlem gören “Yük” miktarı kriterleri olmak üzere 4 adet kriter baz alınmıştır. Kriterlerin ağırlıkları Bulanık DEMATEL yöntemiyle bulunmuş, en önemli kriterin “yolcu sayısı” kriteri olduğu tespit edilmiştir. Havalimanlarının performansları ise MABAC yöntemiyle sıralanmıştır. Yapılan sıralama sonucunda İstanbul’da faaliyet gösteren havalimanlarının ilk 3 sırada yer aldığı görülmüştür. Analizler Excel paket programıyla yapılmıştır.
Lecithin as a Putative Biodegradable Blocker of SARS-CoV-2
Authors: Qaisrani Muhammad Nawaz , Rehman Jawad Ur , Belousov Roman , Goliaei Elham Moharramzadeh , Girotto Ivan , Franklin Ricardo , Güell Oriol , Hassanali Ali , Roldan Edgar
Published: October 2020

Understanding the physical and chemical properties of viral infection at molecular scales is a major challenge of the scientific community in the fight against the Coronavirus (COVID-19) pandemic. We employ all-atoms molecular dynamics simulations to study the interaction between the receptor-binding domain of the SARS-CoV-2 spike protein and the surfactant lecithin in water solutions. Our microsecond simulations reveal a preferential binding of lecithin to the receptor-binding motif (RBM) of SARS-CoV-2. Furthermore, we find that the lecitin-RBM binding events are mainly dominated by the hydrophobic interactions, which are accompanied by dewetting of water molecules near the RBM. These proof-of-concept simulations provide a demonstration of the use of biodegradable phospholipids as blockers of binding of SARS-CoV-2 with the human Angiotensin-Converting Enzyme 2 (ACE2) receptor.
High-Resolution Mining of SARS-CoV-2 Main Protease Conformational Space: Supercomputer-Driven Unsupervised Adaptive Sampling
Authors: Jaffrelot Inizan Theo , Célerse Frédéric , Adjoua Olivier , El Ahdab Dina , Jolly Luc-Henri , Liu Chengwen , Ren Pengyu , Montes Matthieu , Lagarde Nathalie , Lagardère Louis , Monmarché Pierre , Piquemal Jean-Philip
Published: October 2020

We provide a new unsupervised adaptive sampling strategy capable of producing microsecondtimescale molecular dynamics (MD) simulations using many-body polarizable force fields (PFF) on modern supercomputers. The global exploration problem is decomposed into a set of separate MD trajectories that can be restarted within an iterative/selective process to achieve sufficient phase-space sampling within large biosystems, while accurate statistical properties can be obtained through debiasing. With this pleasingly parallel setup, the Tinker-HP package can be powered by an arbitrary large number of GPUs (Graphics Processing Unit) cards available on pre-exascale supercomputers, reducing to days explorations that would have taken years. We applied the approach to the urgent problem of the modeling of the SARS–CoV–2 Main protease (Mpro) dimer. A 15.14 microsecond high-resolution all-atom simulation (AMOEBA PFF) of its apo state is provided and compared to other available long-timescale non-PFF data. Noticeable differences are found between clustering analysis of the simulations, the AMOEBA adaptive results exhibiting a richer conformational space. Overall, our high-resolution AMOEBA structural analysis captures key experimental observations concerning the stability of the oxyanion hole, a marker of activity through the stability of different stacking and salt bridge interactions. A dissymmetry is found between the enzyme protomers that exhibit different volumes. One of them appears fully inactive while the other is "activable", exhibiting some partial activity features. This activity evaluation can be further traced back to the large flexibility of the C terminal domain, fully captured by AMOEBA but not seen in X-rays due to insufficient electron densities related to the domain high mobility. The C–terminal region of the fully inactive protomer is shown to oscillate between several states, one of them interacting with the other protomer active site, therefore potentially modulating down its activity. Overall, these results reinforce the experimental hypothesis of a full inactivation of the apo state and clearly capture the asymmetric nature of protomers. Additional analysis show that the cavities volumes of the active and distal sites are found to be larger in the most active protomer with AMOEBA. To a larger extend, the PFF finds significantly larger cavities than those obtained with classical, non-polarizable simulations. The consequences on druggability are discussed as additional potential druggable cryptic pockets are found. All data produced within this research are fully accessible to the community for further analysis.
A Convenient Way for the Synthesis of Mono N-Alkylated Ethanolamine
Authors: LI ZHE , Yan Changren
Published: October 2020

N-alkylated ethanol amines, especially the N-monoalkylated ethanol amines, feature widely applications in industries. This manuscript would introduce a new methodology to prepare N-monoalkylated ethanol amine derivatives that could avoid potential side reactions forming N,N-dialkylated by-products.
Structural Properties of NdTiO2N and Its Application as Photoanode
Authors: Ma Zili , Chen Kaixuan , Jaworski Aleksander , Rokicińska Anna , Kustrowski Piotr , Dronskowski Richard , Slabon Adam
Published: October 2020

Mixed-anion inorganic compounds offer diverse functionalities as a function of the different physicochemical characteristics of the secondary anion. The quaternary metal oxynitrides, which originate from substituting oxygen anions (O2–) in a parent oxide by nitrogen (N3–), are encouraging candidates for photoelectrochemical (PEC) water splitting owing to their suitable and adjustable narrow band gap and relative negative conduction band (CB) edge. Given the known photochemical activity of LaTiO2N, we investigated the paramagnetic counterpart NdTiO2N. The electronic structure was explored both experimentally and theoretically at the density-functional theory (DFT) level. A band gap (Eg) of 2.04 eV was determined by means of Ultraviolet-visible (UV-vis) spectroscopy, and a relative negative flat band potential of –0.33 V vs. reversible hydrogen electrode (RHE) was proposed via Mott–Schottky measurements. 14N solid state nuclear magnetic resonance (NMR) signals from NdTiO2N could not be detected,which indicates that NdTiO2N is berthollide, in contrast to other structurally related metal oxynitrides. Although the bare particle-based photoanode did not exhibit noticeable photocurrent, Nb2O5 and CoOx overlayers were deposited to extract holes and activate NdTiO2N. Multiple electrochemical methods were employed to understand the key features required for this metal oxynitride in order to fabricate photoanodes.
FTIR, GC-MS and HPLC analysis of Baliospermum montanum (Willd.) Muell. Arg.
Authors: Sushma B K  , Raveesha H R
Published: October 2020

The present work is aimed to determine the chemical constituents in Baliospermum montanum methanolic extracts. An in vitro regenerated procedure was developed for the induction of callus from stem explant cultured on Murashige and Skoog (MS) medium fortified with various concentration and permutations of 2, 4-dichloro phenoxy acetic acid, 1-naphthalene acetic acid, 6-benzyl amino purine and gibberellic acid. FTIR & GC-MS analysis was done according to standard procedure. The quantitative estimation of β-sitosterol was done by HPLC method. Maximum fresh and dry weight of callus was estimated in the combination of GA3 (0.5 mg/L) + NAA (2 mg/L) compared to other concentration. The FTIR analysis showed various functional compounds with different characteristic peak values in the extracts. Major bioactive constituents were recognized in the GC-MS analysis. Root extract revealed the existence of 1-hexadecanol, pentanoic acid, 2-(aminooxy)- and 1-hexacosanol. Leaf extract showed the presence of propanoic acid, 2-oxo-, trimethylsilyl ester, 9,12-octadecadienoic acid (z,z)-, trimethylsilyl ester, docosane, 1,22-dibromo- and pentatriacontane. Stem and stem derived callus exhibit the presence of 1,6,3,4-dihydro-2-deoxy-beta-d-lyxo-hexopyranose, n-hexadecanoic acid and pentanoic acid, 2-(aminooxy). The methanolic extract of leaf exhibited 0.2149 % of β-sitosterol content. There were no peaks observed in the root, stem and stem derived callus. Further studies are necessary for the isolation and characterization of bioactive compounds from B. montanum.
Validated stability indicating HPLC method to quantify lamivudine and dolutegravir in tablets
Authors: Rama Kumar Kandula  , Raja Sundararajan
Published: October 2020

Dovato tablets (lamivudine and dolutegravir combination) are full therapy regimen for the Type 1 human immunodeficiency virus (HIV-1) infection in adults without history of antiretroviral therapy. The aim of present research focused on development of validated stability indicating method for the quantification of lamivudine and dolutegravir in combined dosage form.The separation was achieved on a Cosmicsil C18 column. The mobile phase consisted of 0.1% orthophosphoric acid (pH 3.5) – acetonitrile (50:50, v/v). Photodiode array detector was used to detect the analytes at 258 nm. The method performance was validated in compliance with the recommendations of the International Conference on Harmonization.The method was validated with selectivity, limit of detection (0.262 μg/ml for lamivudine and 0.238 μg/ml for dolutegravir), linearity (150-450 μg/ml for lamivudine and 25-75 μg/ml for dolutegravir), limit of quantification (0.874 μg/ml for lamivudine and 0.793 μg/ml for dolutegravir), accuracy (percent recovery was nearer to 100%), precision (percent relative standard deviation was less than 2.0%) and robustness (system suitability values are within limits). The stability indicating method was performed by under the various stress conditions. Degradants did not interfere with lamivudine and dolutegravir detection. The developed method can suggest that quantification of lamivudine and dolutegravir in quality control of analytical laboratories.
RP-HPLC Method Development and Validation for the Estimation of Midostaurin in Bulk and Pharmaceutical Dosage Form
Authors: Narayanaswamy Harikrishnan  , Gejalakshmi Subramanian  , Hemalatha C N  , Pavankumar V
Published: October 2020

An elementary, Valid, speedy and decisive strategy was developed to determine Midostaurin quantitatively in a fixed dosage form. Effective Chromatographic separation of Midostaurin was achieved by using Hypersil C18 Column (250 mm X 4.6 mm internal diameter, five μm particle size) using a mobile phase composed of Methanol and Buffer in the proportion of 75:25(by volume). The Mobile phase was siphoned using a gradient HPLC system at a flow rate of 1.0 ml/min, and quantification was based on peak area measurement at 270 nm. RT (Retention Time) for Midostaurin was 2.142 min, and dimensionality of Midostaurin was found to be linear with a statistic value of 0.999. The acceptance criteria of precision were relative variance should be less than 2.0%, and also the strategy showed precision 0.3 for Midostaurin, which shows that the tactic was precise. The full Recovery was found to be 99.96 %. Detection Limit and Quantitation Limit values for Midostaurin were found as 0.439 & 1.466. The exactness and authenticity were assessed by evaluation of validation parameters like linearity, precision, specificity, accuracy, LOD, LOQ values as per ICH guidelines. The proposed strategy has been applied to the formulation without additives interference and specific for the estimation of Midostaurin.
Cardioprotective activity of Piper betle juice in isoproterenol induced hypertrophic rat models
Authors: Doss VA  , Suruthi Arumugam  , Dharaniyambigai Kuberapandian
Published: October 2020

Impaired electrolytes (preferably Na+, K+, Cl-, HCO3-) is one of the key fundamental complications associated with cardiac hypertrophy (enlarged heart) mediated heart failure. Piper betle (P. betle - family Piperaceae) due to its potent antioxidant activity is used in various pharmacological applications. The present study evaluates the cardioprotective (anti-hypertrophic) potential of aqueous (juice) extract of P. betle in restoring electrolyte homeostasis, thereby its ability to curb the fundamental progression of hypertrophy. Isoproterenol (ISO - 10 mg/kg b.w., i.p., 7 days) induced cardiac hypertrophic rats were developed that were simultaneously treated with the standard drug losartan (50mg/kg b.w., orally., 7days) and aqueous juice extract of P. betle (30mg/kg b.w., orally., 7 days). The biochemical estimation of glucose, protein, cholesterol, cardiac marker enzymes like SGOT, SGPT, LDH, enzymatic antioxidants namely SOD, catalase, GPx and electrolytes (Na+, K+, Cl- and bicarbonate) in serum were statistically performed along with the histopathological analysis of left ventricles (H&E stain). The present study showed increased levels of glucose, protein, cholesterol, cardiac marker enzymes, reduced enzymatic antioxidants with reduced electrolytes during cardiac hypertrophy (ISO) that were reflected in a histopathological analysis by thickened abnormal myocardial architecture which was reversed similar to normal in plant juice administered rats. Hence, this study demonstrated the beneficial effect of P. betle (aqueous juice) on electrolytes (Na+, K+, Cl-, HCO3-), thereby imposing an interventional effect against cardiac hypertrophy.
Clinical trial for comparison of clinical performance of I-Gel with LMA-proseal in elective surgeries
Authors: Amit B. Kadam  , Jamale P B
Published: October 2020

The I-gel is genuinely interesting second era aviation route gadget with delicate gel like non inflatable sleeve. The objective of this study was to evaluate and compare the ease of insertion and number of insertion attempts, airway sealing pressure, and evaluation of device position and occurrence of complication. Total70 adult patients were allocated to either i-gel group or P-LMA group with 35patients in each group. Both i-gel and P- LMA were introduced with standard technique. The outcomes measured ease of insertion, number of insertion attempts, airway sealing pressure, changes, evaluation of device position and complications. the i-gel group the success rate at ease of insertion was greater (97% vs72% respectively;P=0.012). Airway sealing pressure was lesser (24.72±1.37 cmH2Ovs 30.09±2.64 cmH2O respectively; P=0.0003). The incidence of postoperative sore throat was lower (2.8% vs 25.7% respectively;P=0.01). Changes in parameters were not clinically significant. The i-gel is easier to insert than P-LMA however with a lower airway sealing pressure. It has a lower incidence of postoperative complications.
Proton Pump Inhibitors Adversely Induce Selective Changes in the Bone Mineral Density Detected by Dual-Energy X-ray Absorptiometry in Postmenopausal Women
Authors: Saleh Y S  , Al-Nimer M S M
Published: October 2020

Dual-energy X-ray absorptiometry (DEXA) is a universal tool that can detect bone loss and diagnose osteoporosis. Long term of using certain drugs contributed to the etiopathology of bone loss. Proton pump inhibitors (PPIs) users are at risk of developing osteoporosis. This study aimed to prove the selectivity of PPIs in inducing bone loss in postmenopausal women by determining the T-score of the axial spine and femur bone. A total number of 215 menopausal women were recruited from a Teaching hospital and private clinics from August 2018 to November 2019. The participants were grouped into Group I, n=150 (had no PPIs treatment) and Group II, n=65 (had treatment with PPIs). All the participants were subjected to DEXA investigation. Group II patients showed significantly lower T-score of the femur bone, while Group I patients showed a significantly lower T-score of lumbar vertebrae. The percentage of Group II patients had a T-score – 2.5 in femur ward bone is 35.4%, while the percentage of Group I patients had a T score -2.5 in the lumbar-3 vertebrae is 35.3%. Moreover, PPIs users showed an acceleration of bone loss despite the age, duration of menopause, body mass index, and waist-to-height ratio. We conclude that PPIs users are at risk of developing bone mass loss in the femur more than in the lumbar vertebrae
Histochemical changes in Piper nigrum Linn leaves infected with galls caused by Diptera
Authors: Asha Renjith  , Payal Lodha
Published: October 2020

Piper Linn. (Black pepper) belongs to the family Piperaceae and an economically and medicinally important spice and is a native of Southern India. The gall tissues have shown various structural and physiological changes in the host tissues. The normal and gall tissue showed differential in terms of the metabolites and enzymes. The Diptera comprises a large group of insects including the common flies, mosquitoes, gnats and midges are by the position of only the pair of wings. Some of them are , others feed on nectar or plant sap and decaying animal and vegetable matter and few others are blood sucking. When feeding on plant tissues these insects and mites inject or secrete a chemical substance into the plant that causes the plant to grow abnormally and produce a gall. Stimulus for gall formation is usually provided by the feeding stage of the insect. in the gall as until the completion and maturity of their life stages and emerges from the exit holes. present investigation, The intensity of starch, cellulose, carbohydrates, proteins, lipids, lignin, and the viz. acid , and oxidase was observed in diseased leaf of Piper and estimated and the results have been discussed in the light of , induced by Diptera.
Rational design of cyclic tetra and pentapeptides as therapeutic agents for dengue NS2B/NS3 protease using structure-based molecular docking (MOE and AutoDock 4.2)
Authors: Nadeem Abdalsatar Abdalrazaq  , Ezatul Ezleen Kamarulzaman
Published: October 2020

Dengue virus infection is one of the health problems in tropical and subtropical countries. Although this disease is common, unfortunately, until now no licensed vaccine or relevant drugs available in the market. The first objective of this study is to design potent and selective peptidic inhibitors by studying the interactions between the designed peptides and the dengue NS2B/NS3 protease using computational docking technique and secondly to compare the quantitative and qualitative docking results using two independent docking programs (MOE and AutoDock 4.2). The proposed peptides were designed based on literature reviews and previous findings on the interaction between dengue NS2B/NS3 protease and reported peptides, thus, we designed ten cyclic tetrapeptides and twenty cyclic pentapeptides. The reported 3D structure of Wichapong and co-workers on the dengue NS2B/NS3 protease homology model was used in this study. The designed peptides were docked using MOE and AutoDock 4.2 softwares targeting dengue NS2B/NS3 protease. The results demonstrated that most of the proposed peptides were connected to the protease binding pocket and made interactions with the protease catalytic triad residues (His51, Asp75 and Ser135). Based on quantitative and qualitative docking results from the two docking programs, it showed that two cyclic tetrapeptides (1-C4 and 4-C4) and four cyclic pentapeptides (4-C5, 16-C5, 20-C5, and 6-C5) are the best potential inhibitors with the lowest free energy of binding and the high number of interactions with protease. In conclusion, the two independent docking programs could give almost the same results based on its quantitative and qualitative docking results. Thus, these potential peptides could serve as promising inhibitors for dengue virus. These findings will be further continued for the synthesis of these cyclic peptides and in vitro biological assays to confirm their activity.
Role of mhealth in the management of Tuberculosis: A new approach to improve adherence
Authors: Rajavardhana T  , Rajanandh M G  , Geethavani M  , Sreedhar V
Published: October 2020

Compliance with Tuberculosis (TB) treatment is essential in enhancing singly and public health as well. may come out with suffering, disease worsening, and mortality and also leads to increased economic burden to the patients. Through this article, we want to explore new ideas to strengthen medication adherence with the assistance of approaches to monitor and enhance TB patient's medication-taking behavior. have more success rates in particular parts, whereas its limitations in improving the adherence can be understood in the world health organization End Tuberculosis plan of action. To provide disease and treatment-related education to the patients, apps should be of educational worth to patients by delivering classified information, which is easily accessible to the patients and caregivers. Hurdles to TB treatment compliance are noteworthy and multiple. Mobile health accounts for an arising field with significant promises to locate barriers, thus enhancing every single individual and community health and health care systems planning.
Studying the Anti-Diabetic Basis of Ayurvedic Formulations –Avipattikara Churna And Triphala Churna
Authors: Dixit Praveen K  , Nagarajan K  , Kumar Sokindra
Published: October 2020

Diabetes mellitus (DM), belongs to the class of metabolic diseases having the primary symptom associated with this disease is high sugar levels in the blood for an extended period. It can be categorized to the world's major diseases considering that affects the high population on the earth and presents two main types I and II.The prevalence of diabetes for all age-groups world-wide was estimated to be 2.8% in 2000 and 4.4% in 2030. Diabetes complications include possible blindness, amputation of a lower limb, renal failure, and cardiac arrest or stroke. There are twenty types of Pramehas (Kaphaja-10 Pittaja-6, and Vataja-4) have been mentioned in the Ayurveda. ‘Prameha’ and ‘Diabetes’ are synonymous. Diabetes is one of the ‘Prameha’ which consists of two words, ‘Pra’ meaning abundant, and ‘Meha' meaning 'passing of large quantity of Urine. Incidentally, the term diabetes has been derived from the Greek term 'Diabainein' to mean 'to cross through a siphon' meaning the continuous free flow of water and applied to mean the elimination of large quantity of Urine. Thus the terms ‘Prameha’ and ‘Diabetes’ carry similar meaning. This review summarizes the two Ayurvedic formulations for both types of DM, which are mentioned in the Ayurvedic Formulary of India. Till now, various kinds of synthetic and herbal formulations were made, and many are more frequently used to achieve desirable treatment. Patients prefer oral anti-diabetic medications since they are more comfortable to be administered, and for this reason, researchers focus their studies in this direction. This review aimed to explore the possibility of anti-diabetic treatment from herbal sources well mentioned in Ayurvedic Formulary of India that is Avipattikara Churna, Triphala Churna.Triphala Churna
A synthesis and review of ethnomedicinal uses, phytochemistry and biological activities of Antidesma venosum E. Mey. ex Tul. (Phyllanthaceae)
Authors: Alfred Maroyi
Published: October 2020

Antidesma venosum is an evergreen to semi-deciduous tree used traditionally to treat various human and animal diseases. This review aims to provide an overview and critically analyze the ethnomedical uses, phytochemistry and biological activities of A. venosum. The results of the current study are based on literature survey conducted using various search engines such as Elsevier, Pubmed, Google Scholar, PubMed, Springer, Science Direct, Taylor and Francis, and pre-electronic sources such as books, book chapters, scientific journals and other grey literature. The bark, fruit, leaf, root and stem bark decoction or infusion of A. venosum are mainly used for magical rituals, as anthelmintic and ethnoveterinary medicine, and traditional cure for epilepsy, hernia, malaria, skin infections, oral candidiasis, snakebites, sexually transmitted infections, abdominal pains, menstrual problems, respiratory infections, infertility, and gastrointestinal infections. The chemical constituents identified from A. venosum include essential oils, isoquinoline alkaloids, triterpenoids, lactones, phytosterols, saponins, cardiac glycosides, tannins and flavonoids. The species possesses a wide range of biological activities which include antibacterial, antimycobacterial, antifungal, anti-inflammatory, antioxidant, antischistosomal, mutagenic and cytotoxicity activities. Antidesma venosum is a valuable medicinal plant species, and future research should focus on animal experiments aimed at assessing toxicity and clinical efficacy of species extracts.
The biofilm eradication activity of C-10 massoialactone against Staphylococcus aureus
Authors: Hasyrul Hamzah  , Triana Hertiani  , Sylvia Utami Tunjung Pratiwi  , Titik Nuryastuti
Published: October 2020

C-10 massoaialactone is a major component of stem bark essential oils Massoia aromatica Becc, which has potential as antibacterial and antifungal but antibiofilm activity against S. aureus has never been reported. The discovery of anti-biofilm drug candidates is needed to overcome infections associated with biofilms. This study aims to determine the eradication activity of C-10 massoialactone against S. aureus biofilms. Antibacterial testing and eradication activity of S. aureus biofilms was determined using the microtiter broth method. The effectiveness of C-10 massoilactone against S. aureus biofilm was analyzed by calculating the value of minimum biofilm eradication concentration. The mechanism of action of C-10 massoilactone against S. aureus biofilms was tested using scanning electron microscopy (SEM). C-10 massoilactone 1% gives antibacterial activity of 86.80% ± 0.01 and can eradication S. aureus biofilm by 68.98% ± 0.01 and not much different from the eradication activity of chloramphenicol drug control. The results also provide evidence that C-10 masoaialactone can damage the extracellular polymeric substance (EPS) matrix and S. aureus biofilm morphology. Therefore, C-10 masoaialactone is very potential to be developed as a candidate for a new antibiofilm drug against S. aureus biofilm.
Surgical Correction of Congenital Double Lip - A Case Report
Authors: Janani Kandamani  , Sudarssan Subramaniam Gouthaman  , Divya Sanjeevi Ramakrishnan  , Santhosh Kumar M. P.
Published: October 2020

Lip provides an attractive and pleasing appearance to the face. Lip anomaly is by the presence of excess fold or redundant or tissue on side of the lip which is referred as double lip. It can be either congenital or acquired and unilateral or bilateral. Such rare entity can affect either upper lip or lower lip or both as seen in syndrome which can be easily diagnosed clinically and rarely reports were published on congenital double lip. During growth and development, the upper lip possesses an outer cutaneous zone often referred as pars and an inner zone which is known as pars which are the two transverse zones. The non-inflammatory labial mucous gland of the pars and unreasonable abundant tissue results in double lip. Treatment should be carried out by an excision of the and sub tissue, without involvement of the underlying muscle This article is a report of a 10 years old boy with this deformity who presented with the complaint of huge lips causing unaesthetic appearance of face and was surgically managed improving the appearance of the face aesthetically acceptable which in turn improves the confidence level of an individual.
Mirabegron a novel approach in the management of overactive bladder
Authors: Harshith N  , Daniel Joseph  , Kanakavalli K. Kundury  , Sujay Mugaloremutt Jayadeva
Published: October 2020

Many prescriptions are available for the therapy of the overactive bladder, yet assessing and choosing the correct medication is essential. The study was carried to examine whether Mirabegron could be the drug that can be used effectively in treating overactive bladder. To assess the effectiveness of Mirabegron, the field survey for this project was conducted through a structured questionnaire form the doctors in Bengaluru for about two months with the Support of Micro Labs Pvt. Ltd by involving 44 leading Doctors in the City from February- March 2020. The Survey population was chosen based on convenient random sampling. The analysis was done based on the occurrence of overactive bladder observed in their clinical practice every month, the age group, and the gender, who are being affected. It evaluated Mirabegron as a treatment option for incontinence episode and micturition frequency. Results showed noteworthy improvement in the quantity of incontinence episode and the quantity of micturition recurrence by utilising Mirabegron. The study outcomes indicated that Mirabegron promising effect in the management of overactive bladder.
In Silico Prediction Tool for Drug-likeness of Compounds based on Ligand Based Screening
Authors: Ani R  , Anand P S  , Sreenath B  , Deepa O S
Published: October 2020

Drug Likeness prediction is a time-consuming and tedious process. An in-vitro method the drug development takes a long time to come to market. The failure rate is also another one to think about in this method. There are many in-silico methods currently available and developing to help the drug discovery and development process. Many online tools are available for predicting and classifying a drug after analyzing the drug-likeness properties of compounds. But most tools have their advantages and disadvantages. In this study, a tool is developed to predict the drug-likeness of compounds given as input to this software. This may help the chemists in analyzing a compound before actually preparing a compound for the drug discovery process. The tool includes both descriptor-based calculation and fingerprint-based calculation of the particular compounds. The descriptor-calculation also includes a set of rules and filters like Lipinski’s rule, Ghose filter, Veber filter and BBB likeness. The previous studies proved that the fingerprint-based prediction is more accurate than descriptor-based prediction. So, in the current study, the drug-likeness prediction tool incorporated the molecular descriptors and fingerprint-based calculations based on five different fingerprint types. The current study incorporated five different machine learning algorithms for prediction of drug-likeness and selected the algorithm, which has a high accuracy rate. When a chemist inputs a particular compound in SMILES format, the drug-likeness prediction tool predicts whether the given candidate compound is drug or non-drug.
Awareness of Cryo Electro-Tomography among Dental Students
Authors: Nithyanandham Masilamani  , Dhanraj Ganapathy
Published: October 2020

CryoElectronomography (CryoET) is indeed an imaging method used to create high resolution (~1-4 nm) three-dimensional viewpoints of specimen, usually physiological macromolecules as well as cell lines. CryoET is really a highly specialized implementation of scanning electron microscopy cryomicroscopy whereby the specimen are scanned since they are tilted, triggering a series of Image data which can be processed to create a 3d image, analogous to 3D images, similar to a CT scan of the human body. This survey was done for assessing the awareness of Cryo electro tomography amongst dental students. This was a questionnaire oriented cross-sectional type of survey comprising 100 dental college students in Chennai. A self-designed questionnaire comprising ten questions based on the knowledge and awareness aboutCryo-electron tomography amongst dental college students. Questionnaires were circulated through an online website survey planet. The questions explored the awareness of using Cryo-electron tomography as a tool to study various biological applications. After the responses were received from 100 participants, data was collected and analyzed .7% are aware about Cryo Electro-tomography. 3% are aware of the mechanism of action of Cryo Electro-tomography. 5% are aware of the diagnostic applications of Cryo Electro-tomography. 3% are aware of the limitations Cryo Electro-tomography.91% are willing to learn about Cryo Electro-tomography. This study concluded that dental students showed less knowledge and awareness toward Cryo Electro-tomography. There are large gaps in the knowledge and attitudes requiring strong remedial measures.
2014-ben megjelent, jog- és államtudományi tárgyú könyvek annotált bibliográfiája 2. rész
Authors: DE A DE jogi karának oktatói-hallgatói munkaközössége
Published: October 2020

Folyóiratunkban rendszeresen jelenik meg az elmúlt időszak új, hazai szakkönyveiről készült, annotált bibliográfia. Az annotáció a könyv felhasználhatóságáról írott, rövid, tényszerű leírás, amely a bibliográfiai adatok mellett meghatározza a műfajt, illetve röviden körvonalazza a feldolgozott témát és a bemutatott eredményeket is. Az annotációk szerzői valamilyen formában kivétel nélkül kötődnek a Debreceni Egyetem Állam- és Jogtudományi Karához, legyen szó munkatársainkról, óraadóinkról vagy hallgatóinkról, PhD-hallgatóinkról. Ebben a számban a 2014-ben megjelent könyvekről készült leírások második részét közöljük.
2017-ben megjelent, jog- és államtudományi tárgyú könyvek annotált bibliográfiája - 2. rész
Authors: DE A DE jogi karának oktatói-hallgatói munkaközössége
Published: October 2020

Folyóiratunkban rendszeresen jelenik meg az elmúlt időszak új, hazai szakkönyveiről készült, annotált bibliográfia. Az annotáció a könyv felhasználhatóságáról írott, rövid, tényszerű leírás, amely a bibliográfiai adatok mellett meghatározza a műfajt, illetve röviden körvonalazza a feldolgozott témát és a bemutatott eredményeket is. Az annotációk szerzői valamilyen formában kivétel nélkül kötődnek a Debreceni Egyetem Állam- és Jogtudományi Karához, legyen szó munkatársainkról, óraadóinkról vagy hallgatóinkról, PhD-hallgatóinkról. Ebben a számban a 2017-ben megjelent könyvekről készült leírások második részét közöljük.
Strategi Guru PAI dalam Pembelajaran Hadits di SMAN 1 Teladan Yogyakarta
Authors: Indriani Sri Anugrah
Published: October 2020

Penelitian ini bertujuan untuk mendeskripsikan problem solving dalam meningkatkan pemahaman belajar hadits bagi peserta didik di SMAN 1 Teladan Yogyakarta. Penelitian ini penelitian ini bertujuan untuk mendeskripsikan praktek pembelajaran hadits di SMAN 1 Teladan Yogyakarta. Penelitian ini adalah penelitian kualitatif dengan menggunakan metode wawancara dan observasi untuk mendapatkan data yang valid dari narasumber. Hasil penelitian mengungkapkan bahwa pembelajaran hadits di SMAN 1 Teladan Yogyakarta dimulai dengan pembacaan hadits bagi kelas X, kemudian menghafalkan hadits bagi peserta didik kelas XI dan teruntuk kelas XII diberikan tugas berupa penyampaian kultum sebelum memulai pembelajaran PAI. Selain itu, ada faktor yang mempengaruhi pemahaman peserta didik dalam hal ini adalah dari pihak guru dan juga dari peserta didik selaku teman sebaya. Dan juga, tentu ada problem solving atau strategi yang digunakan oleh guru PAI dalam mengatasi permasalahan yang ada terkait dengan pemberian tugas ini, yaitu dengan melalui pembuatan list materi dan kegiatan untuk mentkahrij hadits.
Tujuan Tujuan Pendidikan Islam Berbasis Mabādi ’Khaira Ummah
Authors: Wicaksono Herman
Published: October 2020

Tujuan pendidikan merupakan satu hal yang tak terpisahkan dari setiap penyelenggaraan pendidikan, tak terkecuali dalam pendidikan Islam. Belum adanya rumusan tujuan Pendidikan Islam yang konkret dan terukur menjadi salah satu pemantik munculnya kajian ini. Penelitian ini bertujuan untuk memberikan terobosan baru bagi pendidikan Islam. Melalui penelitian ini penulis rumuskan satu rumusan baru terkait tujuan pendidikan Islam yakni tujuan pendidikan Islam berbasis Mabādi’ Khaira Ummah. Konsep ini merupakan prinsip dalam bidang kemsyarakatan yang dicetuskan oleh salah satu organisasi terbesar di Indonesia, NU, yang menurut pandangan penulis sangatlah relevan untuk dijadikan acuan dalam merumuskan tujuan pendidikan Islam. Untuk itu, melalui penelitian kepustakaan, penulis mencari, mengumpulkan, dan mengolah data berkenaan dengan tujuan pendidikan Islam dan Mabādi’ Khaira Ummah untuk kemudian dirumuskan menjadi satu rumusan tujuan pendidikan Islam yang baru. Walhasil, dari hasil analisa penulis, tujuan pendidikan Islam hendaknya mencetak peserta didik yang memiliki sikap: jujur, dapat dipercaya, menepati janji, adil, gemar tolong menolong, dan konsisten dalam kebaikan.
Comparative Analysis of Implementation of Solar PV Systems Using the Advanced SPECA Modelling Tool and HOMER Software: Kenyan Scenario
Authors: Kibaara Samuel Kariuki , Murage D. K. , Musau P. , Saulo M. J.
Published: October 2020

Globally, attention has majorly been focused on pollution and exhaustion of fossil fuels allied to the conventional energy sources while the non-conventional energy/renewable energy sources have always been considered clean and environmentally friendly. Of the two, the non-conventional (renewable) is being preferred because it is believed to be more environmentally friendly. Renewable Energy Technologies (RETs) especially Solar Photovoltaics have seen many plants being constructed to either supplement the grid or as alternatives for those far from the grid. Solar Photovoltaics plants occupy large tracts of land which would have been used for other economic activities for revenue generation such as agriculture, forestry or tourism in archaeological sites.  The negative impacts slow down the application of Solar PV , but a modelling tool that can easily and quantitively assess the impacts in monetary form would accelerate the Solar PV application. The work presents a developed modelling tool that is able to assess not only the techno-economic impacts but also the environmental impacts in monetary form, for one to be able to determine the viability of a plant in a given region. The results are compared with those of HOMER software.
Phytochemical Study of Endemic Species Helleborus Caucasicus and Helleborus Abchasicus
Authors: Beridze Medea , Kalandia Aleko , Japaridze Indira , Vanidze Maia , Varshanidze Natela , Turmanidze Nazi , Dolidze Ketevan , Diasamidze Inga , Jakeli Eteri
Published: October 2020

The floristic region of Adjara represents “Hotpoint” of Caucasian which is distinguished with the uniqueness of its it relict Colchis flora.It represents one of the most powerful refuge in western Eurasia , which is not touched by the chilling because has the special geographical location. There are 176 endemic plants spread in southern Colchis, of which 45 ones can be used for some medical treatments. The bioecology and detailed phytochemical content of some medicinal plant populations have not been studied so far. The research objective is to study the phytochemical content of endemic species of Helleborus caucasicus and Helleborus abchasicus spread in southern Colchis. The research method for the phytochemical content included the separation analysis, which was performed by using UPLC-MS (Waters Acquity QDa detector). Three Steroidal glycosides were isolated from the MeOH extract of the plants of Helleborus caucasicus and Helleborus abchasicus: Hellebrigenin-D-glucose, 20 – Hydroxyecdysone and Hydroxyecdysone – 3 glucoside. Three Steroidal glycosides and Hydroxyecdysone -3 glucoside have been isolated from the MeOH extract of Helleborus caucasicus.
New Technologies and Innovative Solutions in the Development Strategies of Energy Enterprises
Authors: Borowski Piotr F.
Published: October 2020

Energy companies face challenges arising from the ecological, social and legal environment. The reduction of negative impact on the environment and society while maintaining sustainable development affects the formation of new development strategies and push to introduce the state of art innovative technologies. The main aim of the research is to analyze the importance and role of the adaptation strategy to external requirements and to determine the mechanisms of the occurrence of passive and active adaptation. As a new approach to carrying out strategic analysis, two models were used simultaneously (inductive and hypothetical-deductive) which allows for realization qualitative (interviews, observations) and quantitative (statistical analysis) research methods generally called mixed methods. The study was conducted on the basis of mixed-method analysis of adaptations strategies of enterprises from the energy sector. The results of the conducted research show the influence of particular macroeconomic elements (e.g. technologies, ecologies) on making strategic decisions. The issue of adapting an enterprise to its environment is also related to its involvement in the research and development (R&D) sphere. Depending on the size of the company there are different amounts dedicated to R&D. Regulations and the technological environment force innovations of energy companies in the direction of reducing harmful impact on the environment and society. Legal and political factors (both national and EU) determine the activities of power companies (in each group: small, medium and large) and determine the choice of adaptation strategies. The intensity of adaptation to the requirements of the environment changes depends on the size of the company. Power companies apply passive adaptation strategies and as they increase their position on the market, they begin to implement an active adaptation strategy.
The Use of Zipline Drones Technology for COVID-19 Samples Transportation in Ghana
Authors: Lamptey Emmanuel , Serwaa Dorcas
Published: October 2020

Drone technology has had many general applications in the military, agriculture, data processing industry, security and the health sector. The emergence the novel coronavirus pandemic has increase its revolution in the healthcare industry. Ghana, a western African country, was the first country to programme and deploy automated drones to shuttle medical supplies and samples of suspected COVID-19 patients. By this approach, Ghana was able to respond timely to the pandemic and quickly saved the lives of the general population. This paper presents a narrative study on the use of Zipline drones for transporting samples of suspected COVID-19 patients, the challenges and potential barriers encountered.