bluuebunny/crossref_metadata_2025 huggingface dataset:
Beekeepers’ perceptions toward a new omics tool for monitoring bee health in Europe
Authors: Cini Elena , Potts Simon G. , Senapathi Deepa , Albrecht Matthias , Arafah Karim , Askri Dalel , Bocquet Michel , Bulet Philippe , Costa Cecilia , Rúa Pilar De la , Klein Alexandra-Maria , Knauer Anina , Mänd Marika , Raimets Risto , Schweiger Oliver , Stout Jane C. , Breeze Tom D.
Published: January 2025

Pressures on honey bee health have substantially increased both colony mortality and beekeepers’ costs for hive management across Europe. Although technological advances could offer cost-effective solutions to these challenges, there is little research into the incentives and barriers to technological adoption by beekeepers in Europe. Our study is the first to investigate beekeepers’ willingness to adopt the Bee Health Card, a molecular diagnostic tool developed within the PoshBee EU project which can rapidly assess bee health by monitoring molecular changes in bees. The Bee Health Card, based on MALDI BeeTyping®, is currently on level six of the Technology Readiness Level scale, meaning that the technology has been demonstrated in relevant environments. Using an on-line survey from seven European countries, we show that beekeepers recognise the potential for the tool to improve colony health, and that targeted economic incentives, such as subsidises, may help reduce cost being a barrier to the adoption and frequent use of the tool. Based on the description of the tool, 43% of beekeepers appear to be moderately confident in the effectiveness of the Bee Health Card. This confidence could increase if the tool was easy to use and not time consuming, and a higher confidence could also contribute to raising the probability of accepting extra costs linked to it. We estimate that, in the worst-case scenario, the cost per single use of the Bee Health Card should be between €47–90 across a range of European countries, depending on the labour and postage costs. However, the monetary benefits in terms of honey production could exceed this. In order to successfully tackle colony health issues, it is recommended using the BHC five times per year, from the end to the beginning of winter. Finally, we discuss the knowledge needs for assessing beekeeper health tools in future research.
Epidemiological trends and healthcare disparities in onychomycosis: An analysis of the All of Us research program
Authors: Gupta Aditya K. , Economopoulos Vasiliki , Wang Tong , Piguet Vincent
Published: January 2025

Onychomycosis is a common, difficult to treat nail disorder. Our objective was to explore disparities in current clinical management practices for onychomycosis in patients from underrepresented groups and with specific comorbidities. We conducted a cross-sectional study using the All of Us (AoU) research program. The AoU program gathers survey, and electronic health records from participants in the United States with the aim of increasing the representation of minorities groups in health research under the framework of precision medicine. We identified 18,763 onychomycosis patients (2017–2022) and compared the rates of diagnostic testing, prescription medications and surgical procedures. Younger patients were more likely to receive oral medications, while older patients were more likely to undergo surgical nail procedures. Patients with lower income and education, Black and Hispanic patients were less likely to receive testing to confirm diagnosis, and less likely to receive prescription medications (topical and/or oral) except in the case of fluconazole. Lower income and education were associated with a higher likelihood of debridement and trimming procedures, while Black and Hispanic patients were less likely to undergo these procedures. Patients with disabilities also received different treatments when compared to able-bodied individuals, being less likely to receive ciclopirox, efinaconazole and terbinafine, but more likely to undergo debridement and trimming procedures. There are clear differences in the management of onychomycosis in the different demographic and comorbid populations that we studied. Efforts to reduce these inequalities, such as expanded health coverage, reducing communication barriers and increasing patient and physician education are needed.
Effect of one dose of ceftriaxone during endotracheal intubation on the incidence of aspiration pneumonia in cerebral hemorrhage patients: A randomized, controlled, double-blind clinical study protocol
Authors: Liu Xinyan , Wang Qizhi , Bi Yang , Yue Yanru , Song Xuan
Published: January 2025

Introduction

Patients with cerebral hemorrhage often require a tracheal intubation to protect the airway and maintain oxygenation. Due to the use of analgesic and sedative drugs during endotracheal intubation and the opening of the glottis may easily cause aspiration pneumonia. Ceftriaxone is a semi-synthetic third-generation cephalosporin with strong antimicrobial activity against most gram-positive and gram-negative bacteria. It can effectively prevent and treat aspiration pneumonia.

Methods and analysis

This is a prospective, randomized, controlled, double-blind clinical study. Patients with intracerebral hemorrhage (ICH) undergoing endotracheal intubation in Dong E Hospital of Shandong Province from April 2023 to April 2025 will be enrolled and randomly assigned to the intervention group or control group. The intervention group will be treated using 100mL 0.9% sodium chloride with 2g ceftriaxone intravenously over the course of one hour beginning within two hours after endotracheal intubation. The control group will be given 100mL 0.9% sodium chloride injection intravenously of the course of one hour beginning within two hours after endotracheal intubation. The primary outcome is the incidence of aspiration pneumonia within 48 hours after endotracheal intubation. Secondary outcomes include: intensity of antimicrobial use, length of hospital stay, duration without mechanical ventilation, and 28-day mortality.

Discussion

The primary objective of this study is to explore whether a single dose of ceftriaxone administered during endotracheal intubation in patients with ICH reduced the incidence of pneumonia within 48 hours and provide evidence for the prevention of aspiration pneumonia in patients with ICH with endotracheal intubation.

Trial registration

The trial is registered at the Chinese Clinical Trial Registry: ChiCTR2200066837. Registered on December 19, 2022.
Navigating adulthood: Exploring the transition needs of adolescents and young adults affected by Duchenne or Becker muscular dystrophy
Authors: Barak Sharon , Ackerman Laufer Shirley , Gudinsky Elyashiv Michal , Rubinstein-Shatz Sharon , Davidson Rama , Kaplan Tali
Published: January 2025

For individuals with Duchenne or Becker muscular dystrophy (DMD and BMD, respectively), transitioning to adulthood presents significant challenges. Although considerable attention has been given to facilitating medical transitions due to the complexity of these conditions, less focus has been placed on other aspects of the transition, such as achieving independence. This study assessed the transition needs of people with DMD or BMD, exploring various domains including health, education, employment, living arrangements, transportation, daily activities, and independent personal life. Men with DMD or BMD participated in this cross-sectional study. Transition to adulthood was assessed using Transition Readiness Assessment for Young Adults with DMD. The questionnaire evaluates transitions in health care, education and employment, housing and transportation, activities of daily living, and independent life and autonomy. Factors associated with and predicting transition to adulthood were evaluated using Spearman’s correlations and multiple regression analysis. Forty-two people with DMD or BMD (mean age: 24.3±5.3) participated in this study. The transition domains in which most participants needed help were education and employment (52.5%) and activities of daily living (57.0%). Transition needs that stood out included palliative care (66.6%), employment and education support (76.1%), social worker consultation for housing assistance (76.1%), and assistive device consultation (64.2%). Mobility and breathing function did not correlate with transition level. Number of siblings positively correlated with and predicted most transition domains. Older age predicted only education and employment status. In conclusion, the analysis showed that the most problematic transition domains among people with DMD or BMD were activities of daily living and education and employment. In most transition domains, help needed did not decrease with age and was not affected by function. However, adolescents and adults with more siblings typically reported being more ready to transit to adult life.
Anti-inflammatory effects of moxifloxacin and levofloxacin on cadmium-activated human astrocytes: Inhibition of proinflammatory cytokine release, TLR4/STAT3, and ERK/NF-κB signaling pathway
Authors: Phuagkhaopong Suttinee , Sukwattanasombat Jidapha , Suknuntha Kran , Power Christopher , Wonganan Piyanuch , Vivithanaporn Pornpun
Published: January 2025

Cadmium is a non-essential element and neurotoxin that causes neuroinflammation, which leads to neurodegenerative diseases and brain cancer. To date, there are no specific or effective therapeutic agents to control inflammation and alleviate cadmium-induced progressive destruction of brain cells. Fluoroquinolones (FQs), widely used antimicrobials with effective blood-brain barrier penetration, show promise in being repurposed as anti-inflammatory drugs. Therefore, we aimed to test the efficacy of repurposed FQs for the treatment of cadmium-induced inflammation using cultures of U-87 MG human astrocytes and primary human astrocytes. Both FQs abrogated cadmium-induced interleukin (IL)-6 and IL-8 release from human astrocytes in a concentration and time-dependent manner, although levofloxacin had a stronger inhibitory effect than moxifloxacin. The downregulation of inflammatory cytokine release occurred with a concomitant reduction in cadmium-induced elevations in p65 nuclear factor-κB (NF-κB) and extracellular signal-regulated kinases (ERKs) 1/2 phosphorylation. Additionally, levofloxacin treatment significantly alleviated cadmium-induced activation of phosphorylated NF-κB translocation and toll-like receptor (TLR)-4/signal transducer and activator of transcription (STAT) 3 signaling. Transcriptome analysis revealed that modulation of inflammation-related pathways was the most enriched after FQ treatment. Our data suggest that FQs, particularly levofloxacin, attenuate the inflammatory process mediated by cadmium in human astrocytes. These effects may be mediated, at least in part, by inhibition of immune pathways regulated by TLR4, STAT3, ERK MAPK, and NF-κB.
Protective effect of luteinizing hormone on frozen-thawed ovarian follicles and granulosa cells
Authors: Chen Jie , Yu Boyang , Zhang Shengbo , Wang Zhikang , Dai Yanfeng
Published: January 2025

Ovarian tissue cryopreservation addresses critical challenges in fertility preservation for prepubertal female cancer patients, such as the lack of viable eggs and hormonal deficiencies. However, mitigating follicle and granulosa cell damage during freeze-thaw cycles remains an urgent issue. Luteinizing hormone (LH), upon binding to luteinizing hormone receptors (LHR) on granulosa cells, enhances estrogen synthesis and secretion, contributing to the growth of granulosa cells and follicles. This study examined mouse ovarian follicles and granulosa cells to identify optimal LH treatments using morphological assessments and LIVE/DEAD assays. The study found significant increases in the expression of Leucine-rich G-protein-coupled receptor 5 (Lgr5) and Forkhead box L2 (Foxl2) in mural and cumulus granulosa cells under LH influence, alongside marked reductions in active caspase-3 expression. Double immunofluorescence of Ki67 with Foxl2 and Lgr5 revealed ongoing proliferative activity in granulosa cells post freeze-thaw. In addition, LH treatment significantly boosted the expression of transforming growth factor (TGF-β) and its superfamily members in both granulosa cells and oocytes. These findings suggest that LH addition during cryopreservation can diminish damage to follicles and granulosa cells, offering new strategies to enhance the efficacy of mammalian ovarian cryopreservation.
Enhancing the visual environment of urban coastal roads through deep learning analysis of street-view images: A perspective of aesthetic and distinctiveness
Authors: Zhang Yu , Xiong Xing , Yang Shanrui , Zhang Qinghai , Chi Minghong , Wen Xiaoyu , Zhang Xinyu , Wang Junwei
Published: January 2025

Urban waterfront areas, which are essential natural resources and highly perceived public areas in cities, play a crucial role in enhancing urban environment. This study integrates deep learning with human perception data sourced from street view images to study the relationship between visual landscape features and human perception of urban waterfront areas, employing linear regression and random forest models to predict human perception along urban coastal roads. Based on aesthetic and distinctiveness perception, urban coastal roads in Xiamen were classified into four types with different emphasis and priorities for improvement. The results showed that: 1) the degree of coastal openness had the greatest influence on human perception while the coastal landscape with a high green visual index decreases the distinctiveness perception; 2) the random forest model can effectively predict human perception on urban coastal roads with an accuracy rate of 87% and 77%; 3) The proportion of low perception road sections with potential for improvement is 60.6%, among which the proportion of low aesthetic perception and low distinctiveness perception road sections is 10.5%. These findings offer crucial evidence regarding human perception of urban coastal roads, and can provide targeted recommendations for enhancing the visual environment of urban coastal road landscapes.
The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole
Authors: Seveno Marie , Loubens Manon N. , Berry Laurence , Graindorge Arnault , Lebrun Maryse , Lavazec Catherine , Lamarque Mauld H.
Published: January 2025

A sustained blood-stage infection of the human malaria parasite P. falciparum relies on the active exit of merozoites from their host erythrocytes. During this process, named egress, the infected red blood cell undergoes sequential morphological events: the rounding-up of the surrounding parasitophorous vacuole, the disruption of the vacuole membrane and finally the rupture of the red blood cell membrane. These events are coordinated by two intracellular second messengers, cGMP and calcium ions (Ca2+), that control the activation of their dedicated kinases, PKG and CDPKs respectively, and thus the secretion of parasitic factors that assist membranes rupture. We had previously identified the serine-threonine phosphatase PP1 as an essential enzyme required for the rupture of the surrounding vacuole. Here, we address its precise positioning and function within the egress signaling pathway by combining chemical genetics and live-microscopy. Fluorescent reporters of the parasitophorous vacuole morphology were expressed in the conditional PfPP1-iKO line which allowed to monitor the kinetics of natural and induced egress, as well as the rescue capacity of known egress inducers. Our results underscore a dual function for PP1 in the egress cascade. First, we provide further evidence that PP1 controls the homeostasis of the second messenger cGMP by modulating the basal activity of guanylyl cyclase alpha and consequently the PKG-dependent downstream Ca2+ signaling. Second, we demonstrate that PP1 also regulates the rounding-up of the parasitophorous vacuole, as this step is almost completely abolished in PfPP1-null schizonts. Strikingly, our data show that rounding-up is the step triggered by egress inducers, and support its reliance on Ca2+, as the calcium ionophore A23187 bypasses the egress defect of PfPP1-null schizonts, restores proper egress kinetics and promotes the initiation of the rounding-up step. Therefore, this study places the phosphatase PP1 upstream of the cGMP-PKG signaling pathway, and sheds new light on the regulation of rounding-up, the first step in P. falciparum blood stage egress cascade.
Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independently of beta-tubulin
Authors: Collins J. B. , Dilks Clayton M. , Hahnel Steffen R. , Rodriguez Briana , Fox Bennett W. , Redman Elizabeth , Yu Jingfang , Cooke Brittany , Sihuta Kateryna , Zamanian Mostafa , Roy Peter J. , Schroeder Frank C. , Gilleard John S. , Andersen Erik C.
Published: January 2025

Widespread anthelmintic resistance has complicated the management of parasitic nematodes. Resistance to the benzimidazole (BZ) drug class is nearly ubiquitous in many species and is associated with mutations in beta-tubulin genes. However, mutations in beta-tubulin alone do not fully explain all BZ resistance. We performed a genome-wide association study using a genetically diverse panel of Caenorhabditis elegans strains to identify loci that contribute to resistance to the BZ drug thiabendazole (TBZ). We identified a quantitative trait locus (QTL) on chromosome V independent of all beta-tubulin genes and overlapping with two promising candidate genes, the cytochrome P450 gene cyp-35D1 and the nuclear hormone receptor nhr-176. Both genes were previously demonstrated to play a role in TBZ metabolism. NHR-176 binds TBZ and induces the expression of CYP-35D1, which metabolizes TBZ. We generated single gene deletions of cyp-35D1 and nhr-176 and found that both genes play a role in TBZ response. A predicted high-impact lysine-to-glutamate substitution at position 267 (K267E) in CYP-35D1 was identified in a sensitive strain, and reciprocal allele replacement strains in different genetic backgrounds were used to show that the lysine allele conferred increased TBZ resistance. Using competitive fitness assays, we found that neither allele was deleterious, but the lysine allele was selected in the presence of TBZ. Additionally, we found that the lysine allele significantly increased the rate of TBZ metabolism compared to the glutamate allele. Moreover, yeast expression assays showed that the lysine version of CYP-35D1 had twice the enzymatic activity of the glutamate allele. To connect our results to parasitic nematodes, we analyzed four Haemonchus contortus cytochrome P450 orthologs but did not find variation at the 267 position in fenbendazole-resistant populations. Overall, we confirmed that variation in this cytochrome P450 gene is the first locus independent of beta-tubulin to play a role in BZ resistance.
Missões diplomáticas portuguesas em Viena de Áustria nos fins do século XVII
Authors: Almeida Luís Ferrand de
Published: January 2025

Étant donné les liens étroits entre les deux branches de la Maison d'Autriche, il n'est pas surprenant qu’avec la Restauration portugaise de 1640 et ses conséquences, particulièrement la captivité de l'infant D. Duarte, ainsi qu’une guerre si prolongée entre le Portugal et l'Espagne (1640-1668), les relations entre le Portugal et l'Empire germanique soient devenues impossibles pendant longtemps.
Dans les années 1680 et 1690, le siège de Vienne par les Turcs, la grande bataille qui a sauvé la ville et la longue et dure reconquête qui s’ensuivit suscitèrent des intérêts et quelques formes de soutien ou de participation. Cependant, la barrière de ressentiment qui séparait les deux Cours ne fut pas dissipée.
Le mariage entre D. Pedro et Marie-Sophie de Neubourg, sœur de l'impératrice Éléonore et donc belle-sœur de l'empereur Léopold Ier, contribua à la réconciliation, d'autant plus qu'aux liens familiaux s'ajouta l'évolution de la politique européenne. La neutralité portugaise dans la guerre de la Ligue d'Augsbourg fit naître un projet de médiation et, en 1694, le 2ᵉ marquis d’Arronches fut désigné ambassadeur à Vienne. Cette mission, bien reçue à la cour impériale, se termina bientôt de manière désastreuse. Accusé d’un crime de sang, l’ambassadeur abandonna son poste et s’enfuit en Italie (1696).
D. Pedro II chargea alors l'envoyé portugais aux Pays-Bas, Francisco de Sousa Pacheco, de se rendre à Vienne afin de donner satisfaction à l'empereur et de lui assurer son désir de maintenir une bonne amitié. L'objectif politique fut pleinement atteint (1698), et l'envoyé en profita pour obtenir des informations sur les jeunes archiduchesses, filles de Léopold Ier, dont une, Marie-Anne, finit par épouser D. João V.
L’épisode de l’ambassadeur, le marquis d’Arronches, n’eut donc pas d’impact véritablement préjudiciable sur des relations qui présentaient des avantages pour les deux parties. Très probablement, la question de la succession espagnole poussa Léopold Ier, un des principaux prétendants, à cultiver l'amitié portugaise, compte tenu de la position géographique et, par conséquent, de l'importance stratégique du pays. En juillet 1700, le premier agent diplomatique permanent de l'Empire, le comte de Waldstein, arriva à Lisbonne. En 1703, il participa aux négociations qui menèrent à l'adhésion du Portugal à la Grande Alliance, laquelle soutenait la candidature de l'archiduc Charles d'Autriche au trône espagnol.
La participation portugaise dans la guerre facilita certainement la réalisation d’un projet qui remontait au XVIIᵉ siècle : le mariage de l'héritier de la couronne portugaise, plus tard roi D. João V, avec une archiduchesse (1708). Une fois les liens politiques renforcés, la voie pour des contacts plus intenses était ouverte, comme cela se vérifia au cours du XVIIIᵉ siècle.
En annexe sont publiés 20 documents inédits.
O nascimento do concelho da Batalha
Authors: Gomes Saul António
Published: January 2025

Cette étude analyse le processus historique de la constitution de la municipalité de Batalha, consacrée par une charte royale datée de 1500. Après une description des principaux modèles de peuplement et d’organisation des municipalités dans l’espace géographique de la province d’Estremadura du XIIe au XIVe siècle, l’auteur examine le cas particulier de la localité de Batalha, née à l’ombre du Monastère de Santa Maria da Vitória, dont la construction a commencé vers l’année 1386. Tout au long du XVe siècle, la population locale établit des liens d’identité sociale, culturelle, institutionnelle et politique. Vers 1450, les habitants fixent les lignes de démarcation de la municipalité, à l’insu des autorités légales compétentes.
Néanmoins, la municipalité de Batalha ne verrait le jour que 50 années après cet épisode, grâce à la persistance des forces oligarchiques locales qui n’ont cessé de revendiquer l’établissement d’une nouvelle municipalité au sein du district de Leiria. Ces prétentions ont trouvé un bon accueil dans le contexte favorable de l’évolution politique de la fin du XVe siècle. En effet, avec l’arrivée au trône du roi D. Manuel Ier, un processus de réformes administratives a été initié, notamment dans le domaine des réseaux de pouvoirs locaux. D’autre part, ce monarque a accordé une attention particulière au Monastère de Batalha, panthéon dynastique des générations royales précédentes, auquel il aspirait à accorder une plus grande importance politique. On souhaitait ainsi développer dans la localité de Batalha une dignitas symbolique qui puisse correspondre à la signification politique et mémoriale du mausolée de la dynastie d’Aviz qui y fut érigé.
Elvárt és valós munkavállalói kompetenciák vizsgálata a köz- és versenyszférában
Authors: Bajkai-Tóth Katinka , Garamvölgyi Judit , Rudnák Ildikó
Published: January 2025

Jelen tanulmány a magyar közszféra és a versenyszféra munkaerőpiaci elvárásait, valamint a munkavállalók belépésekor és később megszerzett kompetenciáit vizsgálja. A szakirodalmi részben a magyar munkaerőpiac két nagy szegmensét – köz- és a versenyszféra – mutatják be a szerzők a munkaerőpiaci kompetenciákkal kapcsolatos kutatások és modellek tükrében. Az empirikus részben a kérdőív (N=617) válaszait elemzik statisztikai módszerekkel. Az eredmények azt mutatják, hogy mindkét ágazatban magasak az elvárások a munkavállalókkal szemben, függetlenül attól, hogy a kezdeti vagy a későbbi foglalkoztatási időszakban vannak. Az önbevallások által nyert munkavállalói kompetenciaértékek elemzése alapján megállapítható, hogy mindkét ágazatra magas és hasonló értékek jellemzők, amelyek közül kiemelkedik a segítőkészség, a problémamegoldás és a precizitás. Az elvárt kompetenciák, amiket a két szegmens munkáltatói jelölnek meg, ugyanazok mindkét szféra esetében: precizitás, problémamegoldás, elhivatottság, munkához való pozitív hozzáállás, valamint a csapatmunka képessége.
A Z-generáció fogyasztói attitűdjének vizsgálata a sötét turizmusban az önkéntelen szemmozgás alapján
Authors: Mészáros Boglárka Ágnes , Németh Péter , Csapó János
Published: January 2025

Jelen kutatás a Z-generáció fogyasztói attitűdjét vizsgálja a sötét turizmus kontextusában, a neuromarketing területén népszerűvé vált szemkamerás módszer alkalmazásával. A kutatás célja feltárni, hogy Vajdahunyadi vár, mint népszerű erdélyi desztináció sötét turisztikai kínálatának mely elemei keltik fel a Z-generáció, mint potenciális fogyasztók figyelmét, milyen érzelmi asszociációkat társítanak ezekhez a sötét kínálati elemekhez, illetve hatással van-e a sötét kínálatban megjelenő emberi jelenlét az érzelmi asszociációk minőségére. A kutatás eredményei rávilágítanak arra, hogy a résztevők túlnyomó része negatív érzelmeket társít a vár sötét kínálati elemeihez. Ugyanakkor megfigyelhető, hogy a fogyasztói percepció érzékenyebb az emberi jelenléthez köthető sötét tárgyi elemek vizualizációja esetében, ahol statisztikailag igazolhatóan magasabb a negatív és alacsonyabb a pozitív és semleges érzelmek aránya. Tekintve, hogy a szerzők és a rendelkezésre álló tudományos adatbázisok szerint a hazai és nemzetközi turisztikai szakirodalomban még nem jelent meg hasonló témát és módszert egyszerre ötvöző tudományos munka, jelen kutatás indokoltsága megalapozott, illetve hiánypótlónak tekinthető.
Az akciótanulás, mint a gazdasági felsőoktatás kihívásaira adható módszertani válasz
Authors: Dén-Nagy Ildikó , Király Gábor
Published: January 2025

A felsőoktatási intézmények az innováció és a regionális fejlődés kulcsfontosságú szereplői, ágensei, amelyek most átmeneti periódushoz érkeztek: a régi, bevált gyakorlatok többé már nem, vagy nem úgy működnek, mint korábban, ugyanakkor még nem jelentek meg kiforrott, széles körben alkalmazott új megoldások. A határátlépésnek ezt az időszakát a gazdasági felsőoktatási intézmények két globális kihívása szemszögéből vizsgálják a szerzők (eltömegesedés és digitalizáció), majd az akciótanulást, mint ezekre a kihívásokra adható lehetséges választ mutatják be, amelyet az empirikus irodalmak áttekintésével is alátámasztanak, külön figyelmet fordítva az előnyökre és hátrányokra. Áttekintik, hogy miként jelent és jelenhet meg a tudományos oktatási gyakorlatban a hagyományos, deduktív pedagógiai eljárások alternatívájaként/kiegészítőjeként ez az induktív, kompetenciamegközelítésű eszköz.
Factores de riesgo ergonómico en trabajadores de fábricas de muebles en el estado de Chihuahua, México
Authors: Gutiérrez Escajeda Maria Teresa , Morales Chávez Emmanuel , Castillo Villanueva Vanessa , Vásquez Vásquez Gisela
Published: January 2025

La aplicación de los métodos de evaluación ergonómica es útil cuando se desea identificar actividades que, potencialmente, pueden ser un factor de riesgo en el desarrollo de trastornos musculoesqueléticos (TME) para los trabajadores. En el presente estudio se realizó una evaluación ergonómica en la industria mueblera de la región centro-sur del estado mexicano de Chihuahua, con la finalidad de identificar las posturas de mayor riesgo y aplicar el método de evaluación rápida de miembros superiores (RULA, por sus siglas en inglés) para determinar el nivel de riesgo en el desarrollo de TME; y, generar una base sobre la cual se propongan los cambios pertinentes en el método y diseño de trabajo para mejorar la calidad de vida laboral. Los resultados arrojaron que, de la muestra de 31 trabajadores evaluados, el 29% identificaron la presencia de dolor en la espalda, el 24% en el cuello y el 13% en las muñecas, principalmente. Además, los resultados del método RULA, mostraron que en el 89% de las fábricas de muebles, los trabajadores del área de ensamble se encuentran en un nivel de riesgo alto de desarrollar TME, por lo que se considera la urgencia de cambios en las tareas desarrolladas por los trabajadores.
Efecto de la permeabilidad en el factor de seguridad de presas de tierra bajo precipitaciones
Authors: Flores Berenguer Isaida , Rodríguez Odalys Jacobo , García Martínez Samantha , González Haramboure Yoermes , García Tristá Jenny
Published: January 2025

En esta investigación, se relacionan la permeabilidad y el contenido volumétrico de agua para evaluar su influencia en el factor de seguridad de presas de tierra homogéneas de 30 metros de altura. Para ello, se consideran cinco casos de análisis, incluyendo suelos arcillosos en el terraplén, uno para cada caso; un prisma de drenaje y una base impermeable. Estableciendo tres relaciones entre la permeabilidad y el contenido volumétrico de agua, a partir de los parámetros propios de los estudios de suelos y con el empleo de las ecuaciones de Terzaghi y Schlichter, se constituyen las condiciones fundamentales de la investigación. Se consideran cinco días de lluvia continua para tres intensidades, relacionadas con la permeabilidad saturada de cada suelo. Para ello, se emplea un modelo híbrido de elementos finitos y de equilibrio límite, mediante el programa GeoStudio (2018). El resultado permite establecer una relación entre el tiempo de falla, el método de estimación de la permeabilidad y el factor de seguridad para las intensidades de lluvia, observando que, con la aplicación del método de Schlichter, el factor de seguridad decrece abruptamente en las primeras 48 horas, mientras que para el método de Terzaghi los resultados muestran una mayor similitud con los obtenidos a partir de los parámetros propios de los estudios de suelos.
Regional governance as a success factor in protected area management. Network analysis of the Lüneburg Heath Nature Park (Germany)
Authors: Ströbel Kerstin , Job Hubert , Von Ruschkowski Eick
Published: January 2025

Protected areas are crucial for landscape-scale conservation, but striking a balance between centralised guidance (heteronomy) and local autonomy (self-determination) is essential. This balance is particularly important for parks that cross administrative boundaries or impose land-use restrictions, as these factors can impact local acceptance and actors’ responsibilities. Analysing governance structures can unveil communication effectiveness, power distribution and collaboration levels within protected areas. This paper presents a network analysis intended to obtain empirical evidence of the above. To the best of our knowledge, this is the first such analysis to be conducted in a German conservation context. This approach reveals responsibility distributions and motives behind spatial interventions. In the pilot study of the Lüneburg Heath Nature Park, 34 actors were identified. In the core group, data was generated from 12 semi-structured expert interviews. We identified existing communicative and collaborative structures between key actors, local rights holders and stakeholders facing implementation challenges. Leveraging structures like the ‘Nature Conservation Coordination Group’, which has the status of a higher-level assembly, can encourage an open communication culture and affirm each actor’s value. We conclude that strengthening existing governance structures and implementing them on the ground, even on an informal basis, is essential for fostering a shared understanding and greater acceptance of landscape-scale conservation issues.
PERAN PENDAMPING PEKERJA MIGRAN PEREMPUAN DALAM MENCEGAH TINDAK PIDANA PERDAGANGAN ORANG DI KABUPATEN KENDAL
Authors: Khasanah Dian Ratu Ayu Uswatun , Rizkiana Rina Elsa , Khanifa Nurma Khusna , Pongantung Ronald Jolly , Muzammil Moh.
Published: January 2025

Praktik Tindak Pidana Perdagangan Orang (TTPO) merupakan salah satu kasus migran yang terjadi di Kabupaten Kendal. Pendamping migran menjadi jembatan dalam memberikan pendampingan bagi pekerja migran perempuan. Metode yang digunakan dalam penelitian ini adalah metode pendekatan yuridis empiris dengan didukung data primer melalui wawancara secara mendalam dengan pendamping dan calon pekerja migran maupun mantan pekerja migran di Kabupaten Kendal. Hasil penelitian ini menunjukkan bahwa peran pendamping pekerja migran dilakukan secara mandiri dan sukarela dalam menagani masalah para pekerja migran perempuan. Dengan memberikan pendampingan kepada para pekerja migran perempuan dan keluarganya yang mengalami masalah pada saat bekerja dan setelah bekerja di luar negeri dengan memberikan pendidikan kritis, memberikan pemberdayaan ekonomi, memberikan pelatihan bagi yang sudah kembali ke Indonesia.
Female diminutives in English Translations of Czech Texts (based on the examples from Michal Ajvaz »Druhé město« and Karel Čapek »Válka s mloky« using the Czech corpora)
Authors: Rubach Joanna
Published: January 2025

This article is devoted to female diminutives in English Translations of Czech texts. The research for this article was conducted using the Czech corpora (korpus.cz) where the author created a query to analyze two texts originally written in Czech. The author briefly describes the struggle of translating Czech diminutives to English, as these two languages have quite different stylistic forms. The subject of the analysis is female Czech diminutives in the texts Druhé město by Michal Ajvaz and Válka s mloky by Karel Čapek and the measure of equivalence used when translating said diminutives to English
Amatorskie słowniczki brneńskiego hantecu – ich rola i zastosowanie
Authors: Juszczak Bartosz
Published: January 2025

Artykuł porusza zagadnienie roli i zastosowania amatorskich wydań leksykograficznych i dydaktycznych brneńskiego hantecu – socjolektu powstałego przed I wojną światową w Brnie. Autor dokonuje oglądu literatury przedmiotu oraz analizy jakościowej dwóch słowników hantecu pod kątem ich budowy. W artykule została zwrócona szczególna uwaga na obiektywizm materiału leksykalnego i samych autorów. Poza konkluzjami lingwistycznymi autor wskazuje, że omawiane słowniki pełnią ważną rolę regionalną i mogą być traktowane jako nośnik zmaterializowanych wartości terytorialnych, kulturowych i tożsamościowych Brna i jego mieszkańców.
Sokrates, czyli człowiek wolny w komunistycznej Czechosłowacji
Authors: Firlej Agata
Published: January 2025

Punktem wyjścia do badań prezentowanych w artykule jest koncepcja Jana Patočki dotycząca dwóch możliwych postaw wolnościowych wobec przewagi reżimu totalitarnego: sokratejskiej (otwarta konfrontacja) i platońskiej (emigracja wewnętrzna). Pierwszy, radykalny sposób praktykowania wolności został opisany na przykładzie losów wybranych postaci kultury czechosłowackiej: Jana Patočki, Jiřego Nĕmca i Evy Kantůrkovej, których bezkompromisowe decyzje narażały na śmierć, wygnanie lub uwięzienie. Wskazane zostaną trzy najważniejsze idee, które przyświecały bohaterom artykułu: prawda, duchowość i wola. W konkluzji przypomniane zostają prace ukraińskiego literaturoznawcy, Ołeksandra Bojczenki, poświęcone postawie Sokratesa w kontekście ukraińskiej opozycji.
Morawskość jako jeden z wątków redefiniujących literaturę czeską po zmianach ustrojowych z 1989 roku
Authors: Németh Vítová Lenka
Published: January 2025

The author presents selected works by Czech writers associated with the Moravian region and published after the political changes of 1989 (Ota Filip, Jiří Kratochvil, Antonín Bajaja, Alena Mornštajnová, Kateřina Tučková, Jan Balabán) and highlights how the theme of “Moravianism” in Czech literature not only revealed new possibilities for incorporating elements of authenticity but, more importantly, restored the reputation of the previously profaned concept of literary engagement, and gave renewed relevance – appropriate for the era of freedom – to the concept of agency of literary works.
The Founding Meeting of the Claims Conference and its Record
Authors: Creangă Ovidiu
Published: January 2025

While the history of the Claims Conference has been documented, little is known about the meeting that established the organization over 70 years ago. This study examines the founding of the Claims Conference using its first record, the transcript of the meeting that took place at the Waldorf Astoria Hotel in New York City, on October 25–26, 1951. Many historical accounts about the Claims Conference offer cursory descriptions of its inception without examining the full scope of the debate underlying its founding. A few attempts in recent years have addressed this gap but a need for a more comprehensive analysis remains. This study explores the inaugural meeting through the lens of the organizations that took part in the conference and demonstrates the important role they played in shaping the outcome of the conference. By examining the transcript of that meeting in greater detail, this study contributes to a deeper understanding of the Claims Conference’s origin and of its subsequent history.
Es braucht Beziehungen, auch an Hochschulen
Authors: Tschopp Lukas
Published: January 2025

Die zunehmende Präsenz von KI in der Hochschulbildung wirft Fragen über die Bedeutung menschlicher Beziehungen auf. Der Artikel argumentiert, dass trotz – oder gerade wegen – technologischer Entwicklungen persönliche Beziehungen für erfolgreiches Lernen zentral bleiben. Lehrende und Bibliotheksmitarbeitende spielen dabei eine wichtige Rolle, indem sie Räume für Dialog, kritische Reflexion und echten Austausch schaffen.
Energy Availability in Female Collegiate Beach Volleyball Athletes
Authors: Willingham Brandon D. , Daou Marcos , VanArsdale Jake , Thomas Meghan , Saracino Patrick G.
Published: January 2025

Willingham, BD, Daou, M, VanArsdale, J, Thomas, M, and Saracino, PG. Energy availability in female collegiate beach volleyball athletes. J Strength Cond Res XX(X): 000–000, 2024—Low energy availability (LEA) is a present risk for many female athletes. Yet, the literature on LEA is often reliant on single, short-term, snapshots, which may not be reflective of the chronic energy balance surrounding female athletes in sport. Therefore, the purpose of this study was to establish the current prevalence of LEA in female collegiate beach volleyball athletes during the preseason and across the competitive season. One-way repeated measures analysis of variance was used to compare measures of EA (i.e., dietary intake, activity energy expenditure [EE], body composition) and EE (i.e., resting metabolic rate and thermic effect of feeding) at 4 timepoints—once in the preseason (i.e., Fall), and 3 times across the 10-week competitive season in Spring (i.e., week 1, week 5, and week 9). Significance was set at p ≤ 0.05. Although mean EA was in the subclinical zone (i.e., 30–45 kcal·kg FFM−1·d−1) at each timepoint, the prevalence of LEA for individuals was 30.8% in the preseason, 37.5% at week 1, 25.0% at week 5, and 62.5% at week 9. Further, carbohydrate intake was below the recommended range for power athletes at each timepoint, suggesting that female beach volleyball athletes with LEA may benefit from increasing carbohydrate intake. Despite no statistical differences in body mass across the season (p = 0.577), there was a trend for increasing fat-free mass (p = 0.062) as the season progressed. Importantly, LEA is not a team-wide condition but an individual one. Therefore, approaches to mitigate LEA should be individualized.
Effect of Fitness Level on Time Course of Recovery After Acute Strength and High-Intensity Interval Training
Authors: Grammenou Maria , Kendall Kristina L. , Wilson Cody J. , Porter Tenielle , Laws Simon M. , Haff G. Gregory
Published: January 2025

Grammenou, M, Kendall, KL, Wilson, CJ, Porter, T, Laws, SM, and Haff, GG. Effect of fitness level on time course of recovery after acute strength and high-intensity interval training. J Strength Cond Res XX(X): 000–000, 2024—The aim was to investigate time course of recovery after acute bouts of strength (STR) and high-intensity interval training (HIIT). A secondary goal was to assess the influence of total fitness score (TFS), composed of handgrip strength and maximum aerobic power on recovery. Twenty-eight resistance-trained individuals completed 8 testing sessions within a 14- to 17-day period. Subjects performed a testing battery comprising isometric midthigh pull (IMTP), countermovement jump (CMJ), and a modified Wingate test (WINmod) at baseline, immediately after exercise, as well as at 6 and 24 hours after the training sessions. A one-way ANOVA was performed to examine time changes after the training sessions. Subjects were then grouped based on their TFS in high, medium, and low groups. To examine the influence of TFS on time course of recovery, we performed a linear mixed-effects model. Statistical significance was set at p < 0.05. Both training sessions resulted in a significant reduction in peak force (PF) that persisted for up to 6 (p < 0.05) and 24 hours (p < 0.001). The STR session showed immediate and 24-hour postexercise declines in jump height and reactive strength index modified (RSImod) compared with baseline. The low TFS group exhibited a significant RSImod reduction immediately after HIIT (p < 0.001), compared with the medium TFS group (p = 0.0002). In the STR session, the high TFS group displayed an increased eccentric displacement during CMJ 24 hours after exercise compared with baseline (p = 0.033). Overall, subjects with high TFS may be able to recover CMJ performance at the same rate as other TFS groups, despite performing more work.
Time Perception and Enjoyment of Professional Soccer Players in Different Training Sessions: Implications for Assessment of Session-RPE and Training Load
Authors: Edwards Andrew Mark , Coleman Damian , Fuller James , Kesisoglou Antonis , Menting Stein Gerrit Paul
Published: January 2025

Edwards, AM, Coleman, D, Fuller, J, Kesisoglou, A, and Menting, SGP. Time perception and enjoyment of professional soccer players in different training sessions: Implications for assessment of session-RPE and training load. J Strength Cond Res XX(X): 000–000, 2024—The purpose of this study was to investigate whether the perception of time and enjoyment levels among professional soccer players varied according to the type of training undertaken and whether this influenced the training load (TL) assessment method of session-rating of perceived exertion (sRPE). Sixteen male professional soccer players participated in this study. A diverse range of 7 training events was sampled, comprising passive sessions (e.g., long and short video analysis sessions; VA1 & VA2), sport-specific game play (small-sided games), physical tactical sessions (tactical formation training), individual skills training, and cardiovascular training sessions (long and short; CV1 & CV2). Sessions varied in duration. Subjects estimated duration, enjoyment, and perceived exertion. The activities rated as most enjoyable (all physical training sessions with the exception of CV1 & CV2) were also the sessions considered to last shortest, or time perceived as running fastest (P < 0.01). Long-duration video analysis (VA2) and high-intensity cardiovascular training (without a ball) (CV2) were rated least enjoyable (P < 0.01) and were the sessions where time estimates were longer than chronological time, indicating time perceived as running slow (P < 0.01). Differences in subjective and chronological estimates of sRPE substantially impacted TL estimates across the 5 physically active sessions (P < 0.01). The outcomes of this study indicate that systematic and task-specific variations in time perception and enjoyment exist among professional soccer players. This could be impactful for training design, optimizing the training experience, and reliably assessing TL.
The Impact of Stance Width on Kinematics and Kinetics During Maximum Back Squats
Authors: Larsen Stian , Zee Mark de , Tillaar Roland van den
Published: January 2025

Larsen, S, Zee, Md, and Tillaar, Rvd. The impact of stance width on kinematics and kinetics during maximum back squats. J Strength Cond Res XX(X): 000–000, 2024—This study compared the lower extremity peak net joint moments (NJMs) and muscle forces between wide and narrow stance widths defined as 1.7 and 0.7 acromion width in the last repetition of the concentric phase in 3 repetition maximum back squats. Twelve recreationally trained men (age:25.3 ± 2.9 years, height:179 ± 7.7 cm, body mass:82.8 ± 6.9 kg) volunteered for the study. The NJMs were estimated using inverse dynamics and individual muscle forces with static optimization. The main findings of interest were that the wide stance resulted in statistically smaller knee flexion angles (Cohen's d: 0.9; 95% confidence interval [CI]: −17.96 to −3.18°), knee extension NJMs [d: 1.45; 95% CI: −1.56 to −0.61 Nm·kg−1], and vastii forces [d: 1.3; 95% CI: −27.7 to −0.9.5 N·kg−1] compared with the narrow stance. Moreover, we observed significantly larger hip abduction angles [d: 3.8; 95% CI: 12.04 to 16.86°] for the wide stance. Hence, we suggest that recreationally trained men aiming to optimize muscle forces in the vastii muscles during maximum back squat training should consider adopting a narrow stance.
Targeted nanozyme-enabled treatment of cardiovascular diseases
Authors: Liu Lin , Lv Jie , Wang Xiuxiu , Huang Xiao , Zhang Chenchen , Pan Qingqing , Yan Wei , Qin Zhen
Published: January 2025

Cardiovascular diseases (CVDs) pose a significant threat to human health due to the high mortality and morbidity rates. Traditional drugs often have limited efficacy due to inherent constraints, such as low bioavailability and notable side effects. As a highly regarded therapeutic strategy, nanotechnology offers new perspectives and means for treating CVDs. Nanozyme-based targeted therapeutic drugs specifically address the biological processes in areas affected by CVDs, thereby achieving precise treatment. Compared to traditional drugs, targeted nanozymes offer advantages, such as high efficiency, specificity, controllability, and fewer side effects, showing great efficacy in treating CVDs. This paper first explores the design strategies and mechanisms of nanozyme-based targeted therapy, then introduces its application in key CVDs, such as ischemic stroke, myocardial infarction, and coronary heart disease. Finally, the paper discusses the challenges of introducing targeted nanozymes into clinical applications and the future development prospects in the treatment of CVDs.