bluuebunny/crossref_metadata_2025 huggingface dataset:
In Vivo Activity Of Medications In Different Dosage And Ultrahigh Dilutions
Authors: Komissarenko Anatoly A
Published: December 2021

Biological activity of medical remedies varies depending on the dosage of the medicinal substance. As we analyze the results of the medicinal effect we can determine three areas of its effect. First of all, this is a therapeutic area where its dose-dependent medical effect is demonstrated. When a certain amount of drug in the body it exceeded this causes transition to the toxic area where every medicine causes certain pathological manifestations. Significant decrease of the drug dose demonstrates the area of no effect on the body. At the same time similar body reaction can be observed with homeopathic remedies in ultrahigh dilutions. Classical definition of a dose as an amount of substance introduced into the body is not suitable for homeopathic remedies that often donâ€™t have drug substance molecules at all. The presence of areas of different reaction is explained by the effect of electromagnetic wave emissions of drug substances. It is known that molecules of all medicinal substances have certain frequencies that come into resonance with different body structures, including genes that have similar oscillatory characteristics. This causes expression of certain genes and increase of their activities. Increase of an allopathic substance dose causes voltage increase it its wave and consequently an increase of the effect on the genes. However overdose causes hyperstimulation and exhaustion of the gene under expression and consequently pathological symptoms develop. On the other hand a dose too small cannot stimulate gene activity and this causes a lack of medical effect. As demonstrated by long-term studies, the activity of potentiated remedies (in ultrahigh dilutions) is related to development of coherence. Coherence is a phasic shift of the medicinal wave that occurs with potentiation of a remedy. As the potency is increased, every step, i.e. coherent wave shift decreases, thus increasing the probability of exact coincidence of the drug and gene waves and their contraposition to the wave of a xenobiotic. Wave shift by have the phase of a xenobiotic wave makes them opposite in terms of amplitude. They begin to damp each other and thus pathogenic effects of a xenobiotic are neutralized. In such a way, drug activity on the body is determined by wave characteristics of the medicinal substance molecules. Activity of allopathic medications depends on the dose, e.g. the number of drug substance molecules. Activity of homeopathic medications depends on the degree of their potentiation.
Tropospheric warming over the North Indian Ocean caused by the South Asian anthropogenic aerosols: possible implications
Authors: Fadnavis Suvarna , Chavan Prashant , Joshi Akash , Sonbawne Sunil , Acharya Asutosh , Devara Panuganti , Rap Alexandru , Müller Rolf
Published: December 2021

Abstract. Atmospheric concentrations of South Asian anthropogenic aerosols and their transport play a key role in the regional hydrological cycle. Here, we use the ECHAM6-HAMMOZ chemistry-climate model to show the structure and implications of the transport pathways of these aerosols during spring. Our simulations indicate that large amounts of anthropogenic aerosols are transported from South Asia to the North Indian Ocean (the Arabian Sea and North Bay of Bengal). These aerosols are then lifted into the upper troposphere and lower stratosphere (UTLS) by the convection over the Arabian Sea and Bay of Bengal. In the UTLS, they are further transported to the southern hemisphere (30–40° S) and downward into the troposphere by the secondary circulation induced by the aerosol changes. The carbonaceous aerosols are also transported to the Arctic and Antarctic producing local heating (0.002–0.05 K d−1). The presence of anthropogenic aerosols causes negative radiative forcing (RF) at the TOA (0.90 ± 0.089 W m−2) and surface (−5.87 ± 0.31 W m−2) and atmospheric warming (+4.96 ± 0.24 W m−2) over South Asia (60° E–90° E, 8° N–23° N), except over the Indo-Gangetic plain (75° E–83° E, 23° N–30° N) where RF at the TOA is positive (+1.27 ± 0.16 W m−2) due to large concentrations of absorbing aerosols. The carbonaceous aerosols produced in-atmospheric heating along the aerosol column extending from the boundary layer to the UTLS (0.01 to 0.3 K d−1) and in the stratosphere globally (0.002 to 0.012 K d−1). The heating of the troposphere increases water vapor concentrations, which are then transported from the highly convective region (i.e. the Arabian Sea) to the UTLS (increasing water vapor by 0.02–0.06 ppmv).
Overview: Fusion of radar polarimetry and numerical atmospheric modelling towards an improved understanding of cloud and precipitation processes
Authors: Trömel Silke , Simmer Clemens , Blahak Ulrich , Blanke Armin , Doktorowski Sabine , Ewald Florian , Frech Michael , Gergely Mathias , Hagen Martin , Janjic Tijana , Kalesse-Los Heike , Kneifel Stefan , Knote Christoph , Mendrok Jana , Moser Manuel , Köcher Gregor , Mühlbauer Kai , Myagkov Alexander , Pejcic Velibor , Seifert Patric , Shrestha Prabhakar , Teisseire Audrey , von Terzi Leonie , Tetoni Eleni , Vogl Teresa , Voigt Christiane , Zeng Yuefei , Zinner Tobias , Quaas Johannes
Published: December 2021

Abstract. Cloud and precipitation processes are still a main source of
uncertainties in numerical weather prediction and climate change
projections. The Priority Programme “Polarimetric Radar Observations meet
Atmospheric Modelling (PROM)”, funded by the German Research Foundation
(Deutsche Forschungsgemeinschaft, DFG), is guided by the hypothesis that
many uncertainties relate to the lack of observations suitable to challenge
the representation of cloud and precipitation processes in atmospheric
models. Such observations can, however, at present be provided by the
recently installed dual-polarization C-band weather radar network of the
German national meteorological service in synergy with cloud radars and
other instruments at German supersites and similar national networks
increasingly available worldwide. While polarimetric radars potentially
provide valuable in-cloud information on hydrometeor type, quantity,
and microphysical cloud and precipitation processes, and atmospheric models
employ increasingly complex microphysical modules, considerable knowledge
gaps still exist in the interpretation of the observations and in the
optimal microphysics model process formulations. PROM is a coordinated
interdisciplinary effort to increase the use of polarimetric radar
observations in data assimilation, which requires a thorough evaluation and
improvement of parameterizations of moist processes in atmospheric models.
As an overview article of the inter-journal special issue “Fusion of radar
polarimetry and numerical atmospheric modelling towards an improved
understanding of cloud and precipitation processes”, this article outlines
the knowledge achieved in PROM during the past 2 years and gives
perspectives for the next 4 years.
Estimating vertical wind power density by using tower observation and empirical models over varied desert steppe terrain in northern China
Authors: Zhou Shaohui , Yang Yuanjian , Gao Zhiqiu , Xi Xingya , Duan Zexia , Li Yubin
Published: December 2021

Abstract. A complex and varied terrain has a great impact on the distribution of wind energy resources, resulting in uncertainty in accurately assessing wind energy resources. In this study, three wind speed distributions of kernel, Weibull, and Rayleigh type for estimating average wind power density were first compared by using meteorological tower data from 2018 to 2020 under varied desert steppe terrain contexts in northern China. Then three key parameters of scale factor (c) and shape factor (k) from the Weibull model and surface roughness (z0) were investigated for estimating wind energy resource. The results show that the Weibull distribution is the most suitable wind speed distribution over that terrain. The scale factor (c) in the Weibull distribution model increases with an increase in height, exhibiting an obvious form of power function. While there were two different forms for the relationship between the shape factor (k) and height: i.e., the reciprocal of the quadratic function and the logarithmic function, respectively. The estimated roughness length (z0) varied with the withering period, the growing period, and the lush period, which can be represented by the estimated median value in each period. The maximum and minimum values of surface roughness length over the whole period are 0.15 m and 0.12 m, respectively. The power-law model and the logarithmic model are used to estimate the average power density values at six specific heights, which show greater differences in autumn and winter, and smaller differences in spring and summer. The gradient of the increase in average power density values with height is largest in autumn and winter, and smallest in spring and summer. Our findings suggest that dynamic changes in three key parameters (c, k, and z0) should be accurately considered for estimating wind energy resources under varied desert steppe terrain contexts.
The potential of synthetic aperture radar interferometry for assessing meltwater lake dynamics on Antarctic ice shelves
Authors: Li Weiran , Lhermitte Stef , López-Dekker Paco
Published: December 2021

Abstract. Surface meltwater drains on several Antarctic ice shelves, resulting in surface and sub-surface lakes that are potentially critical for the ice shelf collapse. Despite these phenomena, our understanding and assessment of the drainage and refreezing of these lakes is limited, mainly due to lack of field observations and to the limitations of optical satellite imagery during polar night and in cloudy conditions. This paper explores the potential of backscatter intensity and of interferometric coherence and phase from synthetic aperture radar (SAR) imagery as an alternative to assess the dynamics of meltwater lakes. In four case study regions over Amery and Roi Baudouin ice shelves, East Antarctica, we examine spatial and temporal variations in SAR backscatter intensity and interferometric (InSAR) coherence and phase over several lakes derived from Sentinel-1A/B C-band SAR imagery. Throughout the year, the lakes are observed in a completely frozen state, in a partially frozen state with a floating ice lid and as open-water lakes. Our analysis reveals that the meltwater lake delineation is challenging during the melting period when the contrast between melting snow and lakes is indistinguishable. Despite this finding, we show using a combination of backscatter and InSAR observations that lake dynamics can be effectively captured during other non-summertime months. Moreover, our findings highlight the utility of InSAR-based observations for discriminating between refrozen ice and sub-surface meltwater and indicate the potential for phase-based detection and monitoring of rapid meltwater drainage events. The potential of this technique to monitor these meltwater change events is, however, strongly determined by the satellite revisit interval and potential changes in scattering properties due to snowfall or melt events.
PENENTUAN KELAS PEMANEN KELAPA SAWIT DI PT. DWIWIRA LESTARI JAYA ESTATE
Authors: Maykurnia Nabila , Mirasari Rossy , Rusmini
Published: December 2021

Penelitian ini dilatarbelakangi oleh pentingnya menentukan kriteria kelas pemanen yang merupakan penilaian yang dilakukan ke masing masing pemanen, agar pemanen berkompetisi secara sehat dalam meningkatkan produktivitas, kehadiran dan tidak memanen buah mentah serta menjaga tanamaan dan melakukan pekerjaan yang benar.  Sehingga adanya penilaian ke pemanen ini juga diharapkan mandor panen akan secara mendetail lagi memetakan anggotanya mana yang bagus dan mana yang perlu pengarahan.  Penelitian ini bertujuan untuk mengetahui kriteria kelas pemanen kelapa sawit berdasarkan nilai-nilai produktivitas, kehadiran dan panen buah mentah di PT. Dwiwira Lestari Jaya (DLJ) Estate 1 Kabupaten Berau Provinsi Kalimantan Timur. Penelitian ini menggunakan metode deskriptif kualitatif, dengan mengambil data primer berupa observasi, data lapangan, dokumentasi, wawancara, dan data sekunder berupa dokumen perusahaan. Responden diambil dengan metode sampling jenuh, Hasil penelitian menunjukkan bahwa sebagian besar (46,7%) masuk dalam kategori C yang dimana kategori ini hanya tergolong cukup atau merupakan kelas terendah di antara kelas lainnya, kemudian 33.3% yang masuk dalam kategori B yaitu tergolong baik dan hanya 20% yang masuk kategori A yaitu kelas sangat baik. Hasil ini berdasarkan penilaian produktivitas, kehadiran dan panen buah mentah.
PEMANFAATAN GOOGLE EARTH ENGINE DALAM PEMETAAN PEMETAAN POTENSI KARBON PROVINSI KALIMANTAN TIMUR
Authors: Hertianti Erina , Arifin Dawamul , Wumu Romansah
Published: December 2021

Perubahan iklim merupakan permasalahan serius yang dihadapi dunia internasional. Salah satu factor yang mempengaruhi perubahan iklim adalah pelepasan CO2 yang berasal dari vegetasi/ hutan. Hal tersebut menjadikan pengelolaan dan pemeliharaan vegetasi harus dilakukan dengan baik untuk mencegah pelepasan CO2. Provinsi Kalimantan Timur merupakan salah satu provinsi dengan tutupan vegetasi yang luas. Untuk mengetahui potensi karbon yang dimiliki oleh Provinsi Kalimantan Timur dapat dilakukan perhitungan melalui perhitungan luasan jenis tutupan lahan dan kemudian dikalikan dengan factor pengali dari potensi karbon yang terdapat pada jenis tutupan lahan tersebut. Perhitungan luasan dalam rangka perhitungan potensi karbon dapat dilakukan secara lebih mudah dengan menggunakan Google Earth Engine (GEE) yang mampu melakukan processing data secara serentak/ sekaligus. Pengolahan data juga dapat dilakukan dengan menambahkan parameter-parameter dalam pengolahan image. Pengolahan citra sentinel-2 dalam penentuan tutupan lahan menghasilkan 3 kelas tutupan lahan yakni badan air (384.754,752 ha), pemukiman (463.396,001 ha) dan vegetasi (11.873.800,520 ha). Dari luasan tersebut diperoleh potensi karbon yang ada di Provinsi Kalimantan Timur adalah sebesar 761.267.197,15 ton.
KETEGUHAN LENTUR DAN KETEGUHAN PATAH SAMBUNGAN FINGER JOINT KAYU MERANTI (Shorea sp) PADA POSISI SAMBUNGAN VERTIKAL & HORIZONTAL
Authors: Iskandar  , Priyono Joko , Yusdiansyah
Published: December 2021

Keterbatasan panjang kayu yang tersedia dilapangan mengharuskan bahan elemen sruktur disambung. Namun semakin panjang bahan elemen struktur tersebut, gaya lentur yang akan terjadi akan semakin besar bahkan dapat mengakibatkan patah bila beban yang bekerja pada bahan tersebut tidak seimbang dengan kemampuan dari pada bahan tersebut. Untuk itu perlu diteliti jenis sambungan yang bisa menahan gaya lentur dengan lebih baik. Proses pengujian penelitian ini menggunakan kayu solid dan papan finger joint yang dipotong dengan ukuran 2 cm x 5 cm x 20 cm masing masing sebanyak 15 pengulangan setiap pengujian. Pengujian yang dilakukan antara lain pengujian kadar air, pengujian kerapatan, pengujian MoE dan yang terakhir yaitu pengujian MoR.Dari hasil pengujian MoR dan MoE papan finger joint, didapat bahwa nilai MoE finger joint meningkat 31,75 % terhadap nilai MoE kayu utuh, sedangkan untuk MoR finger joint telah menurun sebesar 24,14 % terhadap MoE kayu utuhnya.
PENAMBAHAN DAGING AYAM PADA PEMBUATAN ABON AMPAS KELAPA (Cocos nucifera L.)
Authors: Hamka  , Ruten Asmina Sunriyani , Marwati  , Nurmarini Eva , Salusu Heriad Daud , Beze Husmul , Yulianto
Published: December 2021

Tujuan penelitian ini adalah untuk mengetahui karakteristik kimia berupa uji kadar air, kadar abu, kadar protein, kadar lemak dan karbohidrat dan organoleptik tingkat kesukaan panelis terhadap warna, aroma, rasa dan tekstur dari abon ampas kelapa yang ditambahkan daging ayam.Penelitian ini menggunakan rancangan acak lengkap (RAL) dengan penambahan ampas kelapa dan daging ayam yang terdiri dari 4 perlakuan dan setiap perlakuan di ulang sebanyak 3 (tiga) kali. Parameter yang diamati pada penelitian ini adalah Uji kadar air, kadar abu, kadar protein, kadar lemak, karbohidrat dan organoleptik yang terdiri dari warna, aroma, rasa dan tekstur. Adapun perlakuan pembuatan abon ampas kelapa yakni perlakuan ampas kelapa 0 gram dan daging ayam 350 gram, ampas kelapa 100 gram daging 250 gram, ampas kelapa 200 gram daging ayam 150 gram dan ampas kelapa 300 gram daging ayam 50 gram. Hasil penelitian menunjukan Hasil uji kimia pembuatan abon menggunakan ampas kelapa sebagai bahan pengisi memiliki kandungan air yang tinggi pada perlakuan dengan daging ayam 350 gram dan ampas kelapa 0 gram dengan nilai kadar air 13.07% tidak sesuai syarat mutu SNI abon. Kadar abu  dan kadar lemak yang tertinggi pada perlakuan dengan daging ayam 50 gram dan ampas kelapa 300 gram  dengan nilai 2.79% dan 40,64%. sementara kadar protein dan karbohidrat yang tertinggi pada perlakuan dengan daging ayam 0 gram dan ampas kelapa 350 gram  dengan nilai rata-rata 25.63% dan 47,97%. Hasil uji organoleptik terhadap pembuatan abon menggunakan ampas kelapa sebagai bahan pengisi dengan penambahan daging ayam memperlihatkan bahwa warna, aroma, rasa dan tekstur terhadap kesukaan panelis menunjukan angka suka yaitu dengan rata - rata nilai tertinggi pada perlakuan dengan daging ayam 150 gram dan ampas kelapa 200 gram dengan nilai rata-rata 3.61(suka), aroma 3.80 (suka), rasa 3.67(suka) dan pada tekstur 3.85(suka).
Crítica al fundamentalismo electoral a través del mecanismo del sorteo: propuestas democráticas de Burnheim y Goodwin desde una perspectiva utópica
Authors: Camarelles Queralt Gabriel
Published: December 2021

El sorteo, practicado por primera vez en Atenas a principios del siglo V a. e. c., ha sido considerado durante mucho tiempo, por parte de la teoría política, como un importante mecanismo democratizador. Sin embargo, este recurso entró en desuso durante el desarrollo de la democracia moderna representativa a favor de las elecciones por votación, un fenómeno que algunos autores han calificado como “fundamentalismo electoral”. El objetivo de este artículo es presentar, comparar y evaluar dos propuestas utópicas de democracia por sorteo ofrecidas por John Burnheim y Barbara Goodwin. La tarea que se plantea es analizar su validez y limitaciones, así como considerar su potencial de cara a mejorar las actuales democracias representativas.
Impact of Social Anxiety and Humor Styles on Mental Health
Authors: Obaid Qazi Novera , Khizar Umbreen , Baloch Umber
Published: December 2021

The present study is a “cross-sectional survey research”; aimed toward monitoring the impact of Social Anxiety and Humor Styles on Mental Health. For the study, 500 subjects (205 males, 295 females) were approached. The sample was obtained through the use of random sampling. “The age range” of the applicants was as of 18 to 31 years. The Liebowitz Social Anxiety Scale by Michael Liebowitz was used to measure the Social Anxiety among the participants, the “four Humor Styles (Affiliative, Self-enhancing, Aggressive and Self-defeating)” be measured by means of Humor Style Questionnaire by Dr. Rod A. Martin, and the Mental Health Inventory (MHI-5) by Veit and Ware was used to measure the Mental Health of the research participants. Results of the study revealed that Social Anxiety and Humor Styles have a significant impact on Mental Health. The study further monitored how men and women differ in terms of Social Anxiety, Humor Styles and Mental Health. The findings suggested that no gender differences exist in Social Anxiety and Mental Health. As far as the four Humor Styles are concerned, no gender difference was found in “Aggressive and Self-enhancing Humor Styles”; while Affiliative and “Self-defeating Humor Styles” varied in terms of gender. The findings of the study suggested that make use of the “Adaptive Humor Styles Affiliative and Self-enhancing” lessens the Social Anxiety and causes amelioration in the Mental Health; while the use of “Mal-adaptive Humor Styles (Aggressive and Self-defeating)” exacerbates the Social Anxiety and causes deterioration in the Mental Health.
The dilemma of cesarean myomectomy: Is it safe or not?
Authors: GÜRSOY Ali , ATASAYAN Kemal , DOĞAN TEKBAŞ Ezgi , İLTER Erdin
Published: December 2021

To evaluate the safety and effectiveness of myomectomy during cesarean section. The data of fifty-four pregnant who underwent cesarean myomectomy and twenty-six pregnant with uterine leiomyoma who had cesarean section without myomectomy between the years of 2017 and 2020 in our tertiary clinic were examined retrospectively. There was no significant difference in terms of maternal age, weeks of gestation, gravida, parity, use of additional uterotonics, type of leiomyoma, size of leiomyoma, cesarean indications, blood transfusion requirement, postoperative fever, preoperative hemoglobin (g/dl), change in hemoglobin (g/dl), preoperative hematocrit (%), change in hematocrit (%), length of hospital stay between the two groups (p˃0.05). While no significant difference was observed according to the location of the leiomyomas between the anterior, fundal and posterior location between the two groups, cervical leiomyomas were significantly higher in the CS group (p˂0.05). This study shows that cesarean myomectomy is a safe procedure in selected cases. It also offers the advantage of avoiding a second operation in patients.
Is there any possibility of uterine sarcoma, STUMP and benign myoma variants in the patients operated for myoma uteri
Authors: TOPÇU Elif Göknur , ÜLKER Volkan , GÜNDÜZ Nermin , GÖKSEVER ÇELİK Hale
Published: December 2021

Malignant pathologies may be observed in the histopathological examination of the patients who were operated with the diagnosis of myoma uteri. We aimed to investigate the rates of detection of uterine sarcoma, smooth muscle tumor of uncertain malignant potential and benign myoma variants who were operated due to myoma uteri. Patients who were operated with the diagnosis of myoma uteri between 2012-2018 were included. Patients with and without malignant pathology were compared in terms of their characteristics. The malignancy was encountered in 39 patients (1.5%) among 2583 patients. A significant difference was found between the patients with and without malignancy in terms of age, admission complaints, and cervical smear results. Patients in the malignant group were found to be older (52.5±11.0 vs 48.1±6.1, p=0.016). Postmenopausal bleeding was significantly a more common complaint in the malignant group (p=0.028). The rate of abnormal cytology in the cervical smear results in the malignant group was 5.1% (p=0.004). Pathology reports of the patients who were operated for myoma uteri may result with malignancy. In the preoperative evaluation, it is necessary to pay attention to the patients’ characteristics, to evaluate the risk factors for the possibility of a malignancy.
Does recurrent pregnancy loss have an inflammatory background?
Authors: GÜVEY Huri , ÇELİK Samettin , SOYER ÇALIŞKAN Canan , YAŞAR Burak , YAZICIOĞLU Bahadır , TÜRE Eda , ULUBAŞOĞLU Hasan
Published: December 2021

Although several pathophysiological mechanisms are defined in etiology recurrent pregnancy loss, still causes of half of the cases haven’t revealed yet. It is reported that inflammatory processes take place in the etiology of the disease. In our study, we aimed to reveal the relationship between recurrent pregnancy loss with white blood cell count (WBC), C-reactive protein (CRP) and ferritin levels. We included our study 90 pregnant women having recurrent miscarriage history and 101 pregnant women without recurrent miscarriages, 191 patients in total. Maternal and gestational age, height, weight, body mass index (BMI), gravidity, parity, abortion and living children count and WBC, CRP and ferritin levels of these pregnant were evaluated retrospectively. According to outcomes, while the age (p = 0.01; p<0.05), gravidity (p = 0.00; p<0.01) and abortion counts (p = 0.004; p<0.01) of the study group were found significantly to be higher than that of the control group, weight measurement of them was significantly lower than that of the control group (p = 0.04; p <0.05). Height and BMI measurements, parity and living children counts of the groups showed no statistically significant difference (p>0.05). While WBC levels of the study group was found to be lower (p=0.045, p<0,05) than that of control group, there was no significant difference regarding ferritin and CRP levels (p> 0.05). In our study, WBC, CRP and ferritin parameters did not indicate the inflammatory background in recurrent pregnancy loss. We think that further prospective randomized controlled studies are required regarding these parameters.
Pelatihan Desain Pembelajaran dengan E-learning Berbasis LMS Moodle
Authors: Silalahi Parulian , Agripina Charlota , Agita Yang
Published: December 2021

Tujuan dari pengabdian ini adalah untuk melatih guru agar memiliki pengetahuan dan keterampilan dalam mendesain dan mengembangkan pembelajaran dengan E-learning berbasis LMS Moodle. Pelatihan ini diberikan pada guru SMP Maria Goretti Sungailiat Bangka. Metode pelaksanaan pengabdian dilakukan dengan tiga phase: phase 1. persiapan; phase 2. pelaksanaan; dan phase 3. Evaluasi. Pelaksanaan pengabdian dilakukan secara tatap muka dan daring. Melalui tatap muka pelatihan diberikan dengan ceramah dan demonstrasi yang diselenggarakan selama 3 kali pertemuan pada bulan Juli 2020 dengan jumlah yang guru yang ikut dalam pelatihan ini sebanyak 10 orang. Secara daring diberikan dengan menggunakan aplikasi Moodle..  Hasil pelatihan menunjukkan bahwa pengetahuan dan keterampilan guru dalam mendesain dan mengembangkan pembelajaran menggunakan aplikasi E-learning LMS Moodle meningkat. Selanjutnya dari aplikasi Moodle yang telah dikembangkan oleh pengabdi untuk pembelajaran yang diberikan guru kepada siswa, dapat  diterapkan dengan baik.
BIODEGRADATION POTENTIAL OF RHIZOSPHERIC MICROORGANISMS OF RHIZOPHORA RACEMOSA IN CRUDE OIL CONTAMINATED MANGROVE SWAMP IN THE NIGER DELTA
Authors: Aina O. R. , Atuanya E. I. , Oshoma C. E. , Omotayo A. E. , Olaleye O. N.
Published: December 2021

Rhizophora racemosa (red mangrove tree) belongs to the family Rhizophoraceae; it is an important constituent of the mangrove swamp in Niger Delta, an oil producing region in Nigeria. The remediation of soils containing organic pollutants is possible with the use of microbial communities when the ecology is understood for potentials maximization. This study investigated the biodegradation potential of rhizospheric microorganisms of Rhizophora racemosa in crude oil- contaminated mangrove swamp in the Niger Delta.The total microbial count was determined by the serial dilution method. The hydrocarbon-utilizing bacteria and fungi were enumerated using Mineral Salts Agar containing crude oil as the sole carbon source. The biodegradation potential of these rhizomicrobes was determined using screen test, shake flask degradation tests, Total Organic Gas (TOG) and Total Petroleum Hydrocarbon (TPH) InfraCal Analyzer (HATR-T2 and CH). The turbidity, total organic gas (TOG-N) and total petroleum hydrocarbon were measured weekly for twenty-eight days. Hydrocarbon-degrading microbes isolated from the rhizosphere were identified as Marinococcus sp., Azotobacter sp., Acinetobacter sp. Aspergillus niger, Aspergillus flavus and Candida albicans. The highest rate of TPH reduction was recorded in Acinetobacter sp. (from 150 mg/L on day 1 to ˂0.0031 mg/L on day 14). This was followed by Candida albicans (148mg/L on day 1 to 2.68mg/L on day 28) and Aspergillus flavus (150mg/L on day 1 to 4.21mg/L on day 28) In conclusion, it can be inferred that the some rhizospheric microbes of Rhizophora racemosa can efficienctly degrade hydrocarbon up to 100% rate over a period of 28 days.
Hyperglycemia results in significant pathophysiological changes of placental spiral artery remodeling and angiogenesis, further contributing to congenital defects
Authors: Qin Yushu , McCauley Naomi , Ding Zehuan , Lawless Lauren , Liu Zhimin , Zhang Ke , Xie Linglin
Published: December 2021

Introduction: Hyperglycemic conditions achieved during pregnancy have been shown to have detrimental effects to fetal development and increase the prevalence of childhood comorbidities. However, the mechanisms in which diabetic pregnancies affect placental development and subsequently contribute to adverse health effects on the mother and offspring remain unclear. Research design and methods: Streptozotocin was used to induce gestational diabetes in mice. In this model, hyperglycemia was established at embryonic day 3.5 (E3.5). Pregnancy mass was collected at E10.5, E12.5, E14.5, and E16.5 for different assessments. Results: Both placental and embryonic weights were found to be significantly elevated at E16.5. At E14.5, a significantly larger junctional zone with increased number of glycogen trophoblasts was found in the placentas from hyperglycemic pregnancies (HG group) compared to the placentas from normoglycemic pregnancies (NG group). Importantly, the HG placenta exhibited decreased trophoblast giant cell (TGC) association and TUNEL+ cells, and increased expression of α-SMA on the spiral artery, suggesting arterial remodeling was impacted. Moreover, the interhemal membrane of the labyrinth layer, was found to be thicker in the HG placentas. Furthermore, hyperglycemia resulted in more offspring congenital defects, which were associated with a thicker interhemal membrane. Conclusions: Together, these results suggest that gestational diabetes perturbs proper placental development and function, specifically spiral artery remodeling and angiogenesis, thereby negatively impacting embryonic development.
Functional mapping of gravitropism and phototropism for a desert tree, Populus euphratica
Authors: Jiang Peng , Ma Nan , Sun Fengshuo , Ye Meixia , Wu Rongling
Published: December 2021

Background: Plants have evolved the dual capacity for maximizing light assimilation through stem growth (phototropism) and maximizing water and nutrient absorption through root growth (gravitropism). Previous studies have revealed the physiological and molecular mechanisms of these two processes, but the genetic basis for how gravitropism and phototropism interact and coordinate with one another to determine plant growth remains poorly understood. Methods: We designed a seed germination experiment using a full-sib F1 family of Populus euphratica to simultaneously monitor the gravitropic growth of the radicle and the phototropic growth of the plumule throughout seedling ontogeny. We implemented three functional mapping models to identify quantitative trait loci (QTLs) that regulate gravitropic and phototropic growth. Univariate functional mapping dissected each growth trait separately, bivariate functional mapping mapped two growth traits simultaneously, and composite functional mapping mapped the sum of gravitropic and phototropic growth as a main axis. Results: Bivariate model detected 8 QTLs for gravitropism and phototropism (QWRF, GLUR, F-box, PCFS4, UBQ, TAF12, BHLH95, TMN8), composite model detected 7 QTLs for growth of main axis (ATL8, NEFH, PCFS4, UBQ, SOT16, MOR1, PCMP-H), of which, PCFS4 and UBQ were pleiotropically detected with the both model. Many of these QTLs are situated within the genomic regions of candidate genes. Conclusions: The results from our models provide new insight into the mechanisms of genetic control of gravitropism and phototropism in a desert tree, and will stimulate our understanding of the relationships between gravity and light signal transduction pathways and tree adaptation to arid soil.
Co-expression modules construction by WGCNA and identify potential hub genes and regulation pathways of postpartum depression
Authors: Deng Zhifang , Cai Wei , Liu Jue , Deng Aiping , Yang Yuan , Tu Jie , Yuan Cheng , Xiao Han , Gao Wenqi
Published: December 2021

Purpose: The purpose of our present study was to, for the first time, identify key genes associated with postpartum depression (PPD) and discovery the potential molecular mechanisms of this condition. Methods: First, microarray expression profiles GSE45603 dataset were acquired from the Gene Expression Omnibus (GEO) in National Center for Biotechnology Information (NCBI). The weighted gene co-expression network analysis (WGCNA) was performed to identify the top three modules from differentially expressed genes (DEGs). Furthermore, cross-validated differential gene expression analysis of the top three modules and DEGs was used to identify the hub genes. Gene set enrichment analysis (GSEA) was conducted to identify the potential functions of the hub genes. We conducted a Receiver Operator Characteristic (ROC) curve to verify the diagnostic efficiencies of the hub genes. Lastly, GSE44132 dataset was used to search the association between the methylation profiles of the hub genes and susceptibility to PPD. Results: Altogether, 8979 genes were identified as DEGs for WGCNA analysis. The turquoise, yellow, and green functional modules were the most significant modules related to PPD development after WGCNA analysis. The enrichment analysis results of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway demonstrated that hub genes in the three modules were mainly enriched in the neurotrophin signaling pathway, chemokine signaling pathway, Fcγ receptor-mediated phagocytosis, and Mitogen-activated protein kinase (MAPK) signaling pathway. Eight genes (HNRNPA2B1, IL10, RAD51, UBA52, NHP2, RPL13A, FBL, SPI1) were identified as “real” hub genes from cross-validation data of the three modules and DEGs, and possessed diagnostic value in PPD. The GSEA suggested that “OLFACTORY_TRANSDUCTION”, “BUTANOATE_METABOLISM”, “MELANOMA”, “AMINOACYL_TRNA_BIOSYNTHESIS”, and “LYSINE_DEGRADATION” were all crucial in the development of PPD. Highly significant differentially methylated positions in the three genes (HNRNPA2B1, RPL13A and UBA52) were identified in the GSE44132. Conclusion: Using WGCNA analysis of GEO data, our present study, for the first time, may contribute to elucidate the pathophysiology of PPD and provide potential diagnostic biomarkers and therapeutic targets for postpartum depression.
Association of COMT, BDNF and 5-HTT functional polymorphisms with personality characteristics
Authors: Tommasi Marco , Sergi Maria Rita , Konstantinidou Fani , Franzago Marica , Pesce Mirko , Fratta Irene La , Grilli Alfredo , Stuppia Liborio , Picconi Laura , Saggino Aristide , Gatta Valentina
Published: December 2021

Background: The real impact of genetic factors on personality is still unknown, even if in literature about 50% of variance in personality traits are considered genetically determined. The determination of the genetic variance in personality traits could promote psychological well-being and the prevention of psychopathologies, because there are many experimental evidences showing that mental illness is associated to personality. Numerous studies have showed that Catechol-O-methyltransferase (COMT), brain derived neurotrophic factor (BDNF) and serotonin transporter (5-HTT) are genes whose variants are associated with personality traits. This aim of this study is the investigation of the association between personality traits and 5-HTTLPR/rs255315-HTT promoter variant, COMT Val158Met and BDNF Val66Met gene polymorphisms. Methods: The sample was composed by 132 healthy female students. Genomic DNA was extracted from buccal swab, while personality was assessed with Cloninger’s Temperament and Character Inventory-Revised (TCI-R). Linear discriminant analysis was used to analyze how personality characteristics can differentiate individuals in relation to their genetic polymorphisms. Results: Data showed that the temperament trait Reward Dependence discriminated individuals with different BDNF variants; Novelty Seeking and Harm Avoidance discriminated individuals with different 5HTTLPR variants; Persistence discriminated individuals with different COMT variants. Conclusions: Since these traits are connected to psychological diseases as depression, social anxiety, anorexia and obsessive-compulsive disorders of personality, the study of their genetic component can be used as intermediary issue to better define the connection between genes and predisposition toward maladaptive behavior and mental illness.
Appraisal of the antimicrobial and cytotoxic potentials of nanoparticles biosynthesized from the extracts of Pelargonium quercetorum Agnew
Authors: Dumlupınar Berrak , Karatoprak Gökçe Şeker , Fırat Mehmet , Akkol Esra Küpeli
Published: December 2021

Aim: The aim of this study is the synthesis of nanosilver particles (AgNPs) from Pelargonium quercetorum Agnew. (Geraniaceae) and evaluation of the antimicrobial and the cytotoxic potential of AgNPs. Methods: The synthesized AgNPs were evaluated for antimicrobial and anticancer efficacy using the minimum inhibition concentration method and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide) assay. Results: The AgNPs inhibited approximately 90% the growth of gram-positive Staphylococcus aureus and gram-negative Esherichia coli and yeast Candida albicans pathogens at a concentration of 500 μg/mL. The synthesized AgNPs showed excellent toxicity in MCF-7 cells, and specifically, pq70 AgNP inhibited the growth of MCF-7 cells by 52% at a concentration of 3.125 μg/mL. Conclusion: It was determined that the AgNPs, which had been synthesized from extracts that contained a high phenolic composition, were smaller in size, and showed high anticancer and antimicrobial properties.
Multidisciplinary of anti-COVID-19 battle: from immunological weapons to ecological interventions
Authors: Boem Federico , Nannini Giulia , Amedei Amedeo
Published: December 2021

The COVID-19 pandemic is not just a medical and epidemiological problem. In fact, its impact concerns numerous aspects of human life (such as social and the political-economic dimension). This review aims at highlighting some crucial and neglected aspects of the pandemic in order to include them into a more general framework for the understanding of the phenomenon. Accordingly, it is structured as follows. First, after e brief recap of COVID-19 onset, it is argued the so-called proximate causes of the pandemic, i.e., the mechanisms by which viruses infect their hosts and the patterns of spread of the resulting pathologies, are not enough for a more adequate understanding of it. Second, it is shown how possible solutions to the risk of an upcoming pandemic involve studying the ultimate causes of this phenomenon. This means understanding not only how COVID-19 has become a global issue but also why it was possible for this to happen. Next, it is argued that is urgent to go to the root of the possible conditions: thus looking at the ecological dimension of diseases, the role of microorganisms in evolution, up to rethinking the organization of health systems. Third, to keep these very different perspectives together entails the study of COVID-19 from the point of view of the relationships between biological entities in a purely systemic dimension. Fourth, special attention is given to the symbiotic perspective offered by the study of the microbiota. It is argued how this perspective on microbiota provides an innovative interpretative lens with which to analyze various aspects (from the immunological to the ecosystemic one) of the pandemic. In conclusion, it is claimed that this field of study could perhaps offer not only elements that will be useful to make the treatment and containment strategies of the pandemic effective in its mechanisms, but also may suggest innovative elements for the solutions about the deep reasons that have made COVID-19 a global issue.
Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids
Authors: Ye Hanlin , Wang Linlin , Ma Li , Ionov Maksim , Qiao Gan , Huang Jianlin , Cheng Li , Zhang Yuxi , Yang Xiaohui , Cao Shousong , Lin Xiukun
Published: December 2021

Backgroud: Protein kinases play an important role in cell proliferation, differentiation, mobility and cell cycle arrest etc. These enzymes act as important targets in developing anticancer agents. Over the years, a large number of protein kinase inhibitors have been discovered and developed as anticancer agents for the treatment of cancers clinically. However, the drug-resiatance and off-targeting limit their effeciancy for the treatment of human cancer. Materials and methods: Alkaloids are an important class of natural products with broad spectrum biological activities. In the past decades, numerus alkaloids with significant anticancer activity by inhibiting protein kinases were identified. In the present mini-review, we will present the key enzymes including mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and janus-activated kinases/signal transducer and activator of transcription (JAK/STAT) targeted by alkaloids and highlight the special sites targeted by alkaloids on protein kinases and/or reversing drug resistance. Additionally, the challenge and prospect of developing alkaloids as new anticancer agents are also discussed. Conclusion: Alkaloids suppressed tumor growth through targeting different signaling pathways mediated by protein kinases of cancer cells. It is conceivable that novel alkaloids anticancer agents with promising clinical value will be developed in the future.
Analysis of Social Phenomenon on Tattoo Using Big Data and Social Network Analysis - News texts for the last year as collated -
Authors: Seo Ran-Sug
Published: December 2021

The purpose of this study was to identify the social phenomena of tattoo, which have been of constant interest in our society, through analysis of social networks collected from big data on what the social phenomena implied in keywords emphasized in newspaper articles over the past year. To this end, by analyzing keywords about tattoos that frequently appeared in newspaper articles, we could see what the main interests of social phenomena related to tattoos were. Data on tattoos were collected from newspaper articles over the past year and analyzed how they formed meaning regarding the relationship structure and centrality between the keywords at issue through social network analysis. These findings provide basic data on social discussions and policy directions related to tattoos in practice and discussions related to ways to improve them. This study is an extension from existing quantitative research by analyzing the social phenomena of tattoos through Bigdata and social network analysis. Apart from statistical surveys or subjective qualitative research, we have approached them with content analysis using big data and social network analysis. The conclusion of this study is as follows. First, as a result of analyzing the word cloud regarding tattoos, it was confirmed that “rose” and “300” were the most prominent, and there were keywords that could analyze various other social phenomena. Second, as a result of analysis by connection centrality, it was proved that the social interest and popularity of tattoos increased. Third, as a result of analysis by eigenvector centrality, the popularity of tattoos was proved. It objectified academic research by attempting research from a different perspective from the analysis of research trends and provided visualized research results of readers.
Skin Care Characteristics According to the General Characteristics of Middle-aged Women Living in Dalian, China
Authors: Piao Yan-Yan , Kang Soo-Kyung
Published: December 2021

This study was attempted to find out whether there are differences in skin care characteristics depending on general characteristics of middle-aged women living in Dalian, China. As a result, age showed significant differences from skin care information source, preferred facial care, academic background showed differences from skin care information source, preferred facial care, occupations showed differences in skin care method, average monthly income from skin care information source, skin care methods, and preferred facial care. Through this study, it was revealed that there are significant differences in skin care characteristics depending on the general characteristics of middle-aged women living in Dalian, China. In particular, skin care information sources were most introduced by friends and acquaintances, and they mainly take care of their skin through home care. This seems to have an impact on relationship culture based on experience and trust even though middle-aged women's social advancement and educational background are gradually increasing under China's reform and opening policy. Therefore, skin care marketing for middle-aged women, who are emerging as a new blue ocean in the Chinese skin beauty market, needs to establish a strategy based on China's relationship culture. The results of this study are meaningful in providing basic data for the development and marketing of skin care programs for middle-aged Chinese women.
Giá trị phản ánh hiện thực của địa danh ở tỉnh Sóc Trăng
Authors: Nguyễn Thúy Diễm , Nguyễn Minh Ca
Published: December 2021

Bài viết nhằm hướng đến giá trị phản ánh hiện thực của địa danh ở Sóc Trăng, bao gồm các khía cạnh: phản ánh lịch sử, địa lý, kinh tế, dân tộc học, tín ngưỡng, tôn giáo, văn học, ngôn ngữ, văn hóa và giao thông. Bài viết góp phần khẳng định giá trị phản ánh hiện thực của địa danh, vai trò quan trọng của địa danh đối với việc tìm hiểu một địa phương, một đất nước. Địa danh chính là những tấm bia lịch sử - văn hóa có ý nghĩa lớn lao, tồn tại từ đời này sang đời khác.
Sắc số, đa thức tô màu và tính duy nhất tô màu của đồ thị K2r
Authors: Lê Xuân Hùng
Published: December 2021

Một trong những vấn đề chủ yếu trong lý thuyết đồ thị là bài toán tô màu đồ thị. Đặc biệt là xác định sắc số, đa thức tô màu và nghiên cứu tính duy nhất tô màu của đồ thị. Trong bài báo này, chúng ta sẽ xác định sắc số, đa thức tô màu và nghiên cứu tính duy nhất tô màu của đồ thị r phần đầy đủ  K2 r.
Một số vấn đề lý luận về xây dựng môi trường chơi ngoài trời cho trẻ mầm non
Authors: Võ Thị Lan , Lê Thị Bích Vân
Published: December 2021

Bài viết trình bày một số vấn đề lý luận về xây dựng môi trường chơi ngoài trời với những nội dung và nguyên tắc cơ bản khi thiết kế sân chơi, trang bị và sắp xếp vật liệu chơi, bố trí không gian sao cho hấp dẫn, khuyến khích được trẻ chủ động tham gia các hoạt động chơi một cách tích cực.
ENTITLEMENT TO USE OF SUBJECTS OF GENERAL LAND RIGHTS GRANTED FOR THE CONSTRUCTION AND MAINTENANCE OF RESIDENTIAL BUILDINGS: SOME PROBLEMS OF REALIZATION
Authors: Krasutski G.
Published: December 2021

The right to use land is integral to ensuring its efficient use. The consistency, complexity and stability of legal regulation of the relevant public relations are designed to ensure the protection of the rights of land users. The article analyzes the scientific approaches, legislation and its practical applications on certain problematic issues of the implementation of the right to use land plots under common law. The author made proposals that can be used to improve legislation on the protection and use of land. Appropriate changes and additions will help to reduce the total number of land disputes, their prompt and reasonable resolution, as well as protect the rights of land users in the exercise of their rights to use land on common law, including from encroachments by other participants in this right.
GENESIS OF THE LEGAL REGULATION OF PRE-TRIAL CRIMINAL PROCEDURE IN THE ANCIENT BELARUSIAN LANDS
Authors: Shkaplerov Y.
Published: December 2021

The article considers the genesis of the legal regulation of pre-trial criminal procedure in the ancient Belarusian lands from the beginning of the XI century. In particular, the provisions of the senior written source of Kievan Rus law – Russkaya Pravda, which regulates such procedural institutions as “svod”, “gonenie sleda”, are analyzed. Thus is considered their essence and opinions of various authors on the designated problems. The author focuses the attention on the fact that the legal regulation of traces fixation of socially dangerous acts, determined by some provisions of the Russkaya Pravda, was taken by the legislator after some centuries and reflected in the Statutes of the Grand Duchy of Lithuania in 1529, 1566, 1588, which were in force on the Belarusian land until the XIX century.