bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of Precipitating Factors of Hepatic Encephalopathy in Chronic Liver Disease Patients in a Tertiary Hospital
Authors: Kabir Md Asadul , Chowdhury Jewel , Bari Md Anwarul , Bodruddoza Kazi , Saha Asim Kumer , Alam Sayik Bin
Published: December 2017

Background: Chronic liver disease (CLD) is commonly encountered by physicians in hospital practice. Hepatic encephalopathy is a serious complication of chronic liver disease, arising most commonly in those with advanced liver cirrhosis. In patients with otherwise stable cirrhosis, hepatic encephalopathy often follows clearly identifiable precipitating events. The aim of study is to find out the precipitating factors and their frequency in patients of CLD presenting with hepatic encephalopathy to prevent mortality and morbidity.Methods: This descriptive observational study was carried out to identify the precipitating factors and their frequency among 50 cases of diagnosed chronic liver disease presenting with hepatic encephalopathy at department of Medicine of Sir Salimullah Medical College & Mitford hospital, Dhaka from July 2012 to December 2012 for a period of 6 months.Results: Among 50 patients, 36 patients (72%) were male, 14 (28%) were female. Study showed that age frequency 14 (28%) were from 41-50 years and 08 (16%) were from 51-60 years, 12 (24%) >60 years of age. Out of 50 patients, the etiology of liver cirrhosis was hepatitis B virus in 28 (56%), hepatitis C virus in 4 (8%), both Hepatitis B & C in 02 (4%) Among 50 patients, 13 (26%)were in Grade-3 and 11 (22%) in Grade-2 Hepatic encephalopathy. According to Child-Pugh scoring 16 (32%) in Grade-C & 09 (18%) in Grade-B. The most common precipitating factors were identified as GI bleeding (28%), Infection (26%), mixed (16%) & unknown (20%). In this study, mortality rate was 32% most of the patients from Child-Pugh class-C.Conclusions: Commonest precipitating factors of hepatic encephalopathy in this study were upper G.I. bleeding, infection, mixed factor and electrolyte imbalance. To prevent hepatic encephalopathy caution must be exercised in putting chronic liver disease patient on diuretics. Early and effective infection control measures and better hygienic conditions in government hospitals are needed to be maintained.J MEDICINE Jan 2018; 19 (1) : 10-14
Utilization of Global Precipitation Datasets in Data Limited Regions: A Case Study of Kilombero Valley, Tanzania
Authors: Koutsouris Alexander , Seibert Jan , Lyon Steve
Published: December 2017

This study explored the potential for bias correction of global precipitation datasets (GPD) to support streamflow simulation for water resource management in data limited regions. Two catchments, 580 km2 and 2530 km2, in the Kilombero Valley of central Tanzania were considered as case studies to explore three GPD bias correction methods: quantile mapping (QM), daily percentages (DP) and a model based (ModB) bias correction. The GPDs considered included two satellite rainfall products, three reanalysis products and three interpolated observed data products. The rainfall-runoff model HBV was used to simulate streamflow in the two catchments using (1) observed rain gauge data; (2) the original GPDs and (3) the bias-corrected GPDs as input. Results showed that applying QM to bias correction based on limited observed data tends to aggravate streamflow simulations relative to not bias correcting GPDs. This is likely due to a potential lack of representativeness of a single rain gauge observation at the scale of a hydrological catchment for these catchments. The results also indicate that there may be potential benefits in combining streamflow and rain gauge data to bias correct GPDs during the model calibration process within a hydrological modeling framework.
Reversible Single-Crystal-to-Single-Crystal Structural Transformation in a Mixed-Ligand 2D Layered Metal-Organic Framework: Structural Characterization and Sorption Study
Authors: Wang Chih-Chieh , Ke Szu-Yu , Chen Kuan-Ting , Hsieh Yi-Fang , Wang Tzu-Heng , Lee Gene-Hsiang , Chuang Yu-Chun
Published: December 2017

A 3D supramolecular network, [Cd(bipy)(C4O4)(H2O)2]·3H2O (1) (bipy = 4,4′-bipyridine and C4O42− = dianion of H2C4O4), constructed by mixed-ligand two-dimensional (2D) metal-organic frameworks (MOFs) has been reported and structurally determined by the single-crystal X-ray diffraction method and characterized by other physicochemical methods. In 1, the C4O42− and bipy both act as bridging ligands connecting the Cd(II) ions to form a 2D layered MOF, which are then extended to a 3D supramolecular network via the mutually parallel and interpenetrating arrangements among the 2D-layered MOFs. Compound 1 shows a two-step dehydration process with weight losses of 11.0% and 7.3%, corresponding to the weight-loss of three guest and two coordinated water molecules, respectively, and exhibits an interesting reversible single-crystal-to-single-crystal (SCSC) structural transformation upon de-hydration and re-hydration for guest water molecules. The SCSC structural transformation have been demonstrated and monitored by single-crystal and X-ray powder diffraction, and thermogravimetic analysis studies.
Association between Multiscale Entropy Characteristics of Heart Rate Variability and Ischemic Stroke Risk in Patients with Permanent Atrial Fibrillation
Authors: Matsuoka Ryo , Yoshino Kohzoh , Watanabe Eiichi , Kiyono Ken
Published: December 2017

Multiscale entropy (MSE) profiles of heart rate variability (HRV) in patients with atrial fibrillation (AFib) provides clinically useful information for ischemic stroke risk assessment, suggesting that the complex properties characterized by MSE profiles are associated with ischemic stroke risk. However, the meaning of HRV complexity in patients with AFib has not been clearly interpreted, and the physical and mathematical understanding of the relation between HRV dynamics and the ischemic stroke risk is not well established. To gain a deeper insight into HRV dynamics in patients with AFib, and to improve ischemic stroke risk assessment using HRV analysis, we study the HRV characteristics related to MSE profiles, such as the long-range correlation and probability density function. In this study, we analyze the HRV time series of 173 patients with permanent AFib. Our results show that, although HRV time series in patients with AFib exhibit long-range correlation (1/f fluctuations)—as observed in healthy subjects—in a range longer than 90 s, these autocorrelation properties have no significant predictive power for ischemic stroke occurrence. Further, the probability density function structure of the coarse-grained times series at scales greater than 2 s is dominantly associated with ischemic stroke risk. This observation could provide valuable information for improving ischemic stroke risk assessment using HRV analysis.
A Method of Abnormal States Detection Based on Adaptive Extraction of Transformer Vibro-Acoustic Signals
Authors: Zou Liang , Guo Yongkang , Liu Han , Zhang Li , Zhao Tong
Published: December 2017

State monitoring is very important for the safe operation of high-voltage transformers. A non-contact vibro-acoustic detection method based on the Blind Source Separation (BSS) was proposed in this paper to promote the development of transformer on-line monitoring technology. Firstly, the algorithm of Sparse Component Analysis (SCA) was applied for the adaptive extraction of vibro-acoustic signals, which utilizes the sorted local maximum values of the potential function. Then, the operating states of the transformer were detected by analyzing the vibro-acoustic signal eigenvectors. Different conditions including running normally, increasing of transformer vibro-acoustic amplitude and changing of frequency component of transformer vibro-acoustic were simulated. Moreover, experiments were carried out in a 220 kV substation. The research results show that the number of mixed noise sources can be estimated and the transformer vibro-acoustic signal was always ranked first in the separation signals. The source signals were effectively separated from the mixed signals while all of the correlation coefficients are more than 0.98 and the quadratic residuals are less than −32 dB. As for the experiments, the vibro-acoustic signal was separated out successfully from two voice signals and two interference signals. The acoustic signal reflection is considered as the main cause of the signal interference, and the transformer volume source model is considered as the main reason of unstable vibro-acoustic signal amplitude. Finally, the simulated abnormal states of the transformer were well recognized and the state of the tested transformer was judged to be normal.
Experimental Evaluation of a Switching Matrix Applied in a Bank of Supercapacitors
Authors: Reveles-Miranda Maria , Flota-Bañuelos Manuel , Chan-Puc Freddy , Pacheco-Catalán Daniella
Published: December 2017

Distributed power generation systems (DPGSs) integrate power sources that tend to be smaller than the typical utility scale, such as for renewable energy sources and other applications. Storage systems that incorporate supercapacitors (SCs) have been proposed to extend the life of batteries and to increase the power capacity of the DPGSs, guaranteeing maximum efficiency. The extraction of energy in SCs is more demanding than in the case of batteries; when SCs have delivered only 75% of their energy, their voltage has already decreased to 50%. Beyond this value, the banks fail to meet the requirements demanded by loads that require a minimum voltage to operate correctly, leaving 25% of the energy unused, thereby limiting the deep charge/discharge cycles that occur. This paper presents a model of a switching matrix applied in a bank of SCs. The model allows the use of a simpler circuit to achieve a large number of serial/parallel-configuration connections (levels), improving the utilization of energy to obtain deep discharge cycles in each SC; therefore, by increasing the average energy extracted from each SC, it extends the power delivery time in the storage bank. The efficiency was verified by experimental results obtained using a bank of six SCs.
Design and Selection of Innovative Primary Circulation Pumps for GEN-IV Lead Fast Reactors
Authors: Borreani Walter , Alemberti Alessandro , Lomonaco Guglielmo , Magugliani Fabrizio , Saracco Paolo
Published: December 2017

Although Lead-cooled Fast Reactor (LFR) is not a new concept, it continues to be an example of innovation in the nuclear field. Recently, there has been strong interest in liquid lead (Pb) or liquid lead–bismuth eutectic (LBE) both critical and subcritical systems in a relevant number of Countries, including studies performed in the frame of GENERATION-IV initiative. In this paper, the theoretical and computational findings for three different designs of Primary Circulation Pump (PCP) evolving liquid lead (namely the jet pump, the Archimedean pump and the blade pump) are presented with reference to the ALFRED (Advanced Lead Fast Reactor European Demonstrator) design. The pumps are first analyzed from the theoretical point of view and then modeled with a 3D CFD code. Required design performance of the pumps are approximatively around an effective head of 2 bar with a mass flow rate of 5000 kg/s. Taking into account the geometrical constraints of the reactor and the fluid dynamics characteristics of the molten lead, the maximum design velocity for molten lead fluid flow of 2 m/s may be exceeded giving rise to unacceptable erosion phenomena of the blade or rotating component of the primary pumping system. For this reason a deep investigation of non-conventional axial pumps has been performed. The results presented shows that the design of the jet pump looks like beyond the current technological feasibility while, once the mechanical challenges of the Archimedean (screw) pump and the fluid-dynamic issues of the blade pump will be addressed, both could represent viable solutions as PCP for ALFRED. Particularly, the blade pump shows the best performance in terms of pressure head generated in normal operation conditions as well as pressure drop in locked rotor conditions. Further optimizations (mainly for what the geometrical configuration is concerned) are still necessary.
The Future of the European Electricity Grid Is Bright: Cost Minimizing Optimization Shows Solar with Storage as Dominant Technologies to Meet European Emissions Targets to 2050
Authors: Norwood Zack , Goop Joel , Odenberger Mikael
Published: December 2017

The European roadmap for the power sector dictates an 80–95% cut of existing levels of carbon dioxide emissions is needed by the year 2050 to meet climate goals. This article describes results from a linear cost optimization investment model, ELIN, coupled with a solar technology model, Distributed Concentrating Solar Combined Heat and Power (DCS-CHP), using published investment costs for a comprehensive suite of renewable and conventional electricity generation technologies, to compare possible scenarios for the future electricity grid. The results of these model runs and sensitivity analyses indicate that: (1) solar photovoltaics (PV) with battery storage will likely play a very large role in meeting European targets; (2) concentrating solar power (CSP) with thermal energy storage is at a slight economic disadvantage with respect to PV to compete economically; (3) the economic potential of wind power is only comparable with solar PV if high wind penetration levels are allowed in the best wind sites in Europe; and (4) carbon capture and nuclear technologies are unlikely to compete economically with renewable technologies in creating a low-carbon future grid.
Large Eddy Simulation Analysis on Confined Swirling Flows in a Gas Turbine Swirl Burner
Authors: Liu Tao , Bai Fuqiang , Zhao Zixuan , Lin Yuzhen , Du Qing , Peng Zhijun
Published: December 2017

This paper describes a Large Eddy Simulation (LES) investigation into flow fields in a model gas turbine combustor equipped with a swirl burner. A probability density function was used to describe the interaction physics of chemical reaction and turbulent flow as liquid fuel was directly injected into the combustion chamber and rapidly mixed with the swirling air. Simulation results showed that heat release during combustion accelerated the axial velocity motion and made the recirculation zone more compact. As the combustion was taking place under lean burn conditions, NO emissions was less than 10 ppm. Finally, the effects of outlet contraction on swirling flows and combustion instability were investigated. Results suggest that contracted outlet can enhance the generation of a Central Vortex Core (CVC) flow structure. As peak RMS of velocity fluctuation profiles at center-line suggested the turbulent instability can be enhanced by CVC motion, the Power Spectrum Density (PSD) amplitude also explained that the oscillation at CVC position was greater than other places. Both evidences demonstrated that outlet contraction can increase the instability of the central field.
Modelling the Small Throw Fault Effect on the Stability of a Mining Roadway and Its Verification by In Situ Investigation
Authors: Piotr Małkowski , Łukasz Ostrowski , Piotr Bachanek
Published: December 2017

The small throw fault zones cause serious problems for mining engineers. The knowledge about the range of fractured zone around the roadway and about roadway’s contour deformations helps a lot with the right support design or its reinforcement. The paper presents the results of numerical analysis of the effect of a small throw fault zone on the convergence of the mining roadway and the extent of the fracturing induced around the roadway. The computations were performed on a dozen physical models featuring various parameters of rock mass and support for the purpose to select the settings that reflects most suitably the behavior of tectonically disturbed and undisturbed rocks around the roadway. Finally, the results of the calculations were verified by comparing them with in situ convergence measurements carried out in the maingate D-2 in the “Borynia-Zofiówka-Jastrzębie” coal mine. Based on the results of measurements it may be concluded that the rock mass displacements around a roadway section within a fault zone during a year were four times in average greater than in the section tectonically unaffected. The results of numerical calculations show that extent of the yielding zone in the roof reaches two times the throw of the fault, in the floor 3 times the throw, and horizontally approx. 1.5 to 1.8 times the width of modelled fault zone. Only a few elasto-plastic models or models with joints between the rock beds can be recommended for predicting the performance of a roadway which is within a fault zone. It is possible, using these models, to design the roadway support of sufficient load bearing capacity at the tectonically disturbed section.
Addition of WEEE Glass to Metakaolin-Based Geopolymeric Binder: A Cytotoxicity Study
Authors: Catauro Michelina , Lancellotti Isabella , Leonelli Cristina
Published: December 2017

Waste Electrical and Electronic Equipment (WEEE) types of glass, including Cathode Ray Tube (CRT) glass, are now separately collected in European Union 28 (EU28) zone. Due to the high level of Pb and Ba in their compositions, this type of waste finds its way to the disposal. In the present research, a geopolymer matrix based on metakaolin is used to blend in fine powder panel and funnel glass from personal computer (PC) and television (TV) monitors. Such waste glass, which cannot be directed to glass melting furnaces, is safely incorporated into a geopolymer matrix. The consolidation of the geopolymeric matrix containing the waste glass was followed by pH and conductibility up to 28 days of curing. Scanning electron microscope equipped with energy dispersive spectroscopy (SEM/EDS) was used to obtain information on the microstructure of the consolidated products. Cytotoxicity tests helped the environmental evaluation of these materials.
Mapping Net Stocked Plantation Area for Small-Scale Forests in New Zealand Using Integrated RapidEye and LiDAR Sensors
Authors: Xu Cong , Morgenroth Justin , Manley Bruce
Published: December 2017

In New Zealand, approximately 70% of plantation forests are large-scale (over 1000 ha) with accurate resource description. In contrast, the remaining 30% of plantation forests are small-scale (less than 1000 ha). It is forecasted that these small-scale forests will supply nearly 40% of the national wood production in the next decade. However, in-depth description of these forests, especially those under 100 ha, is very limited. This research evaluates the use of remote sensing datasets to map and estimate the net stocked plantation area for small-scale forests. We compared a factorial combination of two classification approaches (Nearest Neighbour (NN), Classification and Regression Tree (CART)) and two remote sensing datasets (RapidEye, RapidEye plus LiDAR) for their ability to accurately classify planted forest area. CART with a combination of RapidEye and LiDAR metrics outperformed the other three combinations producing the highest accuracy for mapping forest plantations (user’s accuracy = 90% and producer’s accuracy = 88%). This method was further examined by comparing the mapped plantations with manually digitised plantations based on aerial photography. The mapping approach overestimated the plantation area by 3%. It was also found that forest patches exceeding 10 ha achieved higher conformance with the digitised areas. Overall, the mapping approach in this research provided a proof of concept for deriving forest area and mapping boundaries using remote sensing data, and is especially relevant for small-scale forests where limited information is currently available.
Growth, Physiological, Biochemical, and Ionic Responses of Morus alba L. Seedlings to Various Salinity Levels
Authors: Lu Nan , Luo Zijing , Ke Yuzhou , Dai Li , Duan Hongjing , Hou Rongxuan , Cui Binbin , Dou Suhan , Zhang Yadong , Sun Yuhan , Li Yun
Published: December 2017

Mulberry (Morus alba L.), a moderately salt-tolerant tree species, is considered to be economically important. In this study, 1-year-old mulberry seedlings cultivated in soil under greenhouse conditions were treated with five concentrations of sodium chloride (NaCl; 0%, 0.1%, 0.2%, 0.3%, and 0.5%) for 3 and 21 days. Plant growth parameters were not affected by 0.1% NaCl, but significant reductions were observed after treatment with 0.2%, 0.3%, and 0.5% NaCl. The malondialdehyde content and cell membrane stability of mulberry seedlings exposed to 0.1% NaCl did not change, indicating that mulberry is not significantly affected by low-salinity conditions. The Na contents of various organs did not increase significantly in response to 0.1% NaCl, but the K:Na, Mg:Na, and Ca:Na ratios of various organs were affected by NaCl. Marked changes in the levels of major compatible solutes (proline, soluble sugars, and soluble proteins) occurred in both the leaves and roots of NaCl-treated seedlings relative to control seedlings. Under severe saline conditions (0.5% NaCl), the ability of mulberry to synthesize enzymatic antioxidants may be impaired.
Are Pericentric Inversions Reorganizing Wedge Shell Genomes?
Authors: García-Souto Daniel , Pérez-García Concepción , Pasantes Juan J.
Published: December 2017

Wedge shells belonging to the Donacidae family are the dominant bivalves in exposed beaches in almost all areas of the world. Typically, two or more sympatric species of wedge shells differentially occupy intertidal, sublittoral, and offshore coastal waters in any given locality. A molecular cytogenetic analysis of two sympatric and closely related wedge shell species, Donax trunculus and Donax vittatus, was performed. Results showed that the karyotypes of these two species were both strikingly different and closely alike; whilst metacentric and submetacentric chromosome pairs were the main components of the karyotype of D. trunculus, 10–11 of the 19 chromosome pairs were telocentric in D. vittatus, most likely as a result of different pericentric inversions. GC-rich heterochromatic bands were present in both species. Furthermore, they showed coincidental 45S ribosomal RNA (rRNA), 5S rRNA and H3 histone gene clusters at conserved chromosomal locations, although D. trunculus had an additional 45S rDNA cluster. Intraspecific pericentric inversions were also detected in both D. trunculus and D. vittatus. The close genetic similarity of these two species together with the high degree of conservation of the 45S rRNA, 5S rRNA and H3 histone gene clusters, and GC-rich heterochromatic bands indicate that pericentric inversions contribute to the karyotype divergence in wedge shells.
Nature Cure and Non-Communicable Diseases: Ecological Therapy as Health Care in India
Authors: Alter Joseph , Nair R. , Nair Rukmani
Published: December 2017

With rapidly increasing rates of non-communicable diseases, India is experiencing a dramatic public health crisis that is closely linked to changing lifestyles and the growth of the middle-class. In this essay we discuss how the practice of Nature Cure provides a way of understanding the scale and scope of the crisis, as it is embodied, and a way to understand key elements of a solution to problems that the crisis presents for institutionalized health care. As institutionalized in contemporary India, Nature Cure involves treatment and managed care using earth, air, sunlight, and water as well as a strict dietary regimen. In this regard, the essay shows how Nature Cure’s bio-ecological orientation toward public health, which is grounded in the history of its modern incorporation into India, provides an expansionist, ecological model for holistic care that counters the reductionist logic of bio-medical pharmaceuticalization.
Pets, Purity and Pollution: Why Conventional Models of Disease Transmission Do Not Work for Pet Rat Owners
Authors: Robin Charlotte , Perkins Elizabeth , Watkins Francine , Christley Robert
Published: December 2017

In the United Kingdom, following the emergence of Seoul hantavirus in pet rat owners in 2012, public health authorities tried to communicate the risk of this zoonotic disease, but had limited success. To explore this lack of engagement with health advice, we conducted in-depth, semi-structured interviews with pet rat owners and analysed them using a grounded theory approach. The findings from these interviews suggest that rat owners construct their pets as different from wild rats, and by elevating the rat to the status of a pet, the powerful associations that rats have with dirt and disease are removed. Removing the rat from the contaminated outside world moves their pet rat from being ‘out of place’ to ‘in place’. A concept of ‘bounded purity’ keeps the rat protected within the home, allowing owners to interact with their pet, safe in the knowledge that it is clean and disease-free. Additionally, owners constructed a ‘hierarchy of purity’ for their pets, and it is on this structure of disease and risk that owners base their behaviour, not conventional biomedical models of disease.
Stress-Induced Hyperglycemia in Diabetes: A Cross-Sectional Analysis to Explore the Definition Based on the Trauma Registry Data
Authors: Rau Cheng-Shyuan , Wu Shao-Chun , Chen Yi-Chun , Chien Peng-Chen , Hsieh Hsiao-Yun , Kuo Pao-Jen , Hsieh Ching-Hua
Published: December 2017

Background: The diagnosis of diabetic hyperglycemia (DH) does not preclude a diabetes patient from having a stress-induced hyperglycemic response. This study aimed to define the optimal level of elevated glucose concentration for determining the occurrence of stress-induced hyperglycemia (SIH) in patients with diabetes. Methods: This retrospective study reviewed the data of all hospitalized trauma patients, in a Level I trauma center, from 1 January 2009 to 31 December 2016. Only adult patients aged ≥20 years, with available data on serum glucose and glycated hemoglobin A1c (HbA1c) levels upon admission, were included in the study. Long-term average glucose levels, as A1c-derived average glucose (ADAG), using the equation, ADAG = ((28.7 × HbA1c) − 46.7), were calculated. Patients with high glucose levels were divided into three SIH groups with diabetes mellitus (DM), based on the following definitions: (1) same glycemic gap from ADAG; (2) same percentage of elevated glucose of ADAG, from which percentage could also be reflected by the stress hyperglycemia ratio (SHR), calculated as the admission glucose level divided by ADAG; or (3) same percentage of elevated glucose as patients with a defined SIH level, in trauma patients with and without diabetes. Patients with incomplete registered data were excluded. The primary hypothesis of this study was that SIH in patients with diabetes would present worse mortality outcomes than in those without. Detailed data of SIH in patients with diabetes were retrieved from the Trauma Registry System. Results: Among the 546 patients with DH, 332 (32.0%), 188 (18.1%), and 106 (10.2%) were assigned as diabetes patients with SIH, based on defined glucose levels, set at 250 mg/dL, 300 mg/dL, and 350 mg/dL, respectively. In patients with defined cut-off glucose levels of 250 mg/dL and 300 mg/dL, SIH was associated with a 3.5-fold (95% confidence interval (CI) 1.61–7.46; p = 0.001) and 3-fold (95% CI 1.11–8.03; p = 0.030) higher odds of mortality, adjusted by sex, age, pre-existing comorbidities, and injury severity score, than the 491 patients with diabetic normoglycemia (DN). However, in patients with a defined cut-off glucose level of 350 mg/dL, adjusted mortality in SIH in DM was insignificantly different than that in DM. According to the receiver operating characteristic (ROC) curve analysis, a blood sugar of 233 mg/dL, a glycemic gap of 79 (i.e., blood sugar of 251 mg/dL), and a SHR of 1.45 (i.e., blood sugar of 250 mg/dL) were identified as cut-offs for mortality outcomes, with AUCs of 0.622, 0.653, and 0.658, respectively. Conclusions: In this study, a cut-off glucose level of 250 mg/dL was selected to provide a better definition of SIH in DM than glucose levels of 300 mg/dL or 350 mg/dL.
Adsorption of Pb(II) and Cu(II) by Ginkgo-Leaf-Derived Biochar Produced under Various Carbonization Temperatures and Times
Authors: Lee Myoung-Eun , Park Jin , Chung Jae
Published: December 2017

Ginkgo trees are common street trees in Korea, and the large amounts of leaves that fall onto the streets annually need to be cleaned and treated. Therefore, fallen gingko leaves have been used as a raw material to produce biochar for the removal of heavy metals from solutions. Gingko-leaf-derived biochar was produced under various carbonization temperatures and times. This study evaluated the physicochemical properties and adsorption characteristics of gingko-leaf-derived biochar samples produced under different carbonization conditions regarding Pb(II) and Cu(II). The biochar samples that were produced at 800 °C for 90 and 120 min contained the highest oxygen- and nitrogen-substituted carbons, which might contribute to a high metal-adsorption rate. The intensity of the phosphate bond was increased with the increasing of the carbonization temperature up to 800 °C and after 90 min of carbonization. The Pb(II) and Cu(II) adsorption capacities were the highest when the gingko-leaf-derived biochar was produced at 800 °C, and the removal rates were 99.2% and 34.2%, respectively. The highest removal rate was achieved when the intensity of the phosphate functional group in the biochar was the highest. Therefore, the gingko-leaf-derived biochar produced at 800 °C for 90 min can be used as an effective bio-adsorbent in the removal of metals from solutions.
Response to Comments on Zheng et al. “Association between Promoter Methylation of Gene ERCC3 and Benzene Hematotoxicity” Int. J. Environ. Res. Public Health 2017, 14, 1393
Authors: Xing Caihong , Zheng Min
Published: December 2017

We would like to thank Moshammer and Poteser for their comments [...]
Secondary Metabolic Profiles of Two Cultivars of Piper nigrum (Black Pepper) Resulting from Infection by Fusarium solani f. sp. piperis
Authors: Da Luz Shirlley , Yamaguchi Lydia , Kato Massuo , De Lemos Oriel , Xavier Luciana , Maia José , Ramos Alessandra , Setzer William , Da Silva Joyce
Published: December 2017

Bragantina and Cingapura are the main black pepper (Piper nigrum L.) cultivars and the Pará state is the largest producer in Brazil with about 90% of national production, representing the third largest production in the world. The infection of Fusarium solani f. sp. piperis, the causal agent of Fusarium disease in black pepper, was monitored on the cultivars Bragantina (susceptible) and Cingapura (tolerant), during 45 days’ post infection (dpi). Gas Chromatography-Mass spectrometry (GC-MS) analysis of the volatile concentrates of both cultivars showed that the Bragantina responded with the production of higher contents of α-bisabolol at 21 dpi and a decrease of elemol, mostly at 30 dpi; while Cingapura displayed an decrease of δ-elemene production, except at 15 dpi. The phenolic content determined by the Folin Ciocalteu method showed an increase in the leaves of plants inoculated at 7 dpi (Bragantina) and 7–15 dpi (Cingapura); in the roots, the infection caused a phenolic content decrease in Bragantina cultivar at 45 dpi and an increase in the Cingapura cultivar at 15, 30 and 45 dpi. High Performance Liquid Chromatography-Mass spectrometry (HPLC-MS) analysis of the root extracts showed a qualitative variation of alkamides during infection. The results indicated that there is a possible relationship between secondary metabolites and tolerance against phytopathogens.
Poly-γ-glutamic Acid Synthesis, Gene Regulation, Phylogenetic Relationships, and Role in Fermentation
Authors: Hsueh Yi-Huang , Huang Kai-Yao , Kunene Sikhumbuzo , Lee Tzong-Yi
Published: December 2017

Poly-γ-glutamic acid (γ-PGA) is a biodegradable biopolymer produced by several bacteria, including Bacillus subtilis and other Bacillus species; it has good biocompatibility, is non-toxic, and has various potential biological applications in the food, pharmaceutical, cosmetic, and other industries. In this review, we have described the mechanisms of γ-PGA synthesis and gene regulation, its role in fermentation, and the phylogenetic relationships among various pgsBCAE, a biosynthesis gene cluster of γ-PGA, and pgdS, a degradation gene of γ-PGA. We also discuss potential applications of γ-PGA and highlight the established genetic recombinant bacterial strains that produce high levels of γ-PGA, which can be useful for large-scale γ-PGA production.
Impact of Omega-3 Fatty Acids on the Gut Microbiota
Authors: Costantini Lara , Molinari Romina , Farinon Barbara , Merendino Nicolò
Published: December 2017

Long-term dietary habits play a crucial role in creating a host-specific gut microbiota community in humans. Despite the many publications about the effects of carbohydrates (prebiotic fibers), the impact of dietary fats, such as omega-3 polyunsaturated fatty acids (PUFAs), on the gut microbiota is less well defined. The few studies completed in adults showed some common changes in the gut microbiota after omega-3 PUFA supplementation. In particular, a decrease in Faecalibacterium, often associated with an increase in the Bacteroidetes and butyrate-producing bacteria belonging to the Lachnospiraceae family, has been observed. Coincidentally, a dysbiosis of these taxa is found in patients with inflammatory bowel disease. Omega-3 PUFAs can exert a positive action by reverting the microbiota composition in these diseases, and increase the production of anti-inflammatory compounds, like short-chain fatty acids. In addition, accumulating evidence in animal model studies indicates that the interplay between gut microbiota, omega-3 fatty acids, and immunity helps to maintain the intestinal wall integrity and interacts with host immune cells. Finally, human and animal studies have highlighted the ability of omega-3 PUFAs to influence the gut–brain axis, acting through gut microbiota composition. From these findings, the importance of the omega-3 connection to the microbiota emerges, encouraging further studies.
Joint Effects of PON1 Polymorphisms and Vegetable Intake on Ischemic Stroke: A Family-Based Case Control Study
Authors: Juan Juan , Jiang Xia , Tang Xun , Wu Yiqun , Sun Kexin , Xiang Xiao , Tian Yaohua , Wu Tao , Sun Qi , Kraft Peter , Hu Yonghua
Published: December 2017

Paraoxonase 1 gene (PON1) polymorphisms and dietary vegetable and fruit intake are both established determinants of ischemic stroke (IS). However, little is known about whether these factors jointly influence the risk of IS. We analyzed the main effects of PON1, as well as the interactions between PON1 and dietary vegetable or fruit intake with the risk of total IS and its subtypes in a family-based case-control study conducted among 2158 Chinese participants (1007 IS cases and 1151 IS-free controls) from 918 families. Conditional logistic regression models, with each family as a stratum, were used to examine the association between rs662 and IS. Gene-diet interactions were tested by including a cross-product term of dietary vegetable or fruit intake by rs662_G allele count in the models. Each copy of the PON1 rs662_G allele was associated with 28% higher risk of total IS (p = 0.008) and 32% higher risk of large artery atherosclerosis subtype (LAA) (p = 0.01). We observed an interaction between rs662 and vegetable intake for both total IS (p = 0.006) and LAA (p = 0.02) after adjustment for covariates. Individuals who carry the rs662_A allele may benefit to a greater extent from intake of vegetables and thus be more effectively protected from ischemic stroke, whereas carriers of the G allele may still remain at greater risk for ischemic stroke due to their genetic backgrounds even when they consume a high level of vegetables. More studies are needed to replicate our findings among other populations.
Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52
Authors: Chen Chin-Chuan , Huang Ju-Sui , Wang Tong-Hong , Kuo Chen-Hsin , Wang Chia-Jen , Wang Shu-Huei , Leu Yann-Lii
Published: December 2017

Effective DNA repair enables cancer cells to survive DNA damage induced by chemotherapeutic or radiotherapeutic treatments. Therefore, inhibiting DNA repair pathways is a promising therapeutic strategy for increasing the efficacy of such treatments. In this study, we found that dihydrocoumarin (DHC), a flavoring agent, causes deficiencies in double-stand break (DSB) repair and prolonged DNA damage checkpoint recovery in yeast. Following DNA damage, Rad52 recombinase was revealed to be inhibited by DHC, which results in deficiencies in DSB repair and prolonged DNA damage checkpoint recovery. The deletion of RPD3, a class I histone deacetylase (HDAC), was found to mimic DHC-induced suppression of Rad52 expression, suggesting that the HDAC inhibitor activity of DHC is critical to DSB repair and DNA damage sensitivity. Overall, our findings delineate the regulatory mechanisms of DHC in DSB repair and suggest that it might potentially be used as an inhibitor of the DNA repair pathway in human cells.
Universal Signal Conditioning Technique for Fiber Bragg Grating Sensors in PLC and SCADA Applications
Authors: Allwood Gary , Wild Graham , Hinckley Steven
Published: December 2017

Optical fibre sensors, such as Fibre Bragg Gratings (FBGs), are growing in their utilisation, although very niche in their applications. To enable a more diverse range of end users, expensive application-specific optical fibre interrogation hardware needs to be made compatible with and, ideally, easily incorporated into existing instrumentation and measurement hardware. The Programmable Logic Controller (PLC) is an ideal example of hardware used for data acquisition in many industries. As such, a module that can be connected into an existing PLC slot to collect data from electrically-neutral, EMI-immune and versatile FBG sensors is of significant advantage to the growing optical fibre sensing market. In this work, we show that both digital and analogue signals can be collected from FBG sensors and integrated seamlessly into the PLC-based control system using a transmit-reflect detection system. This technique enables fibre optic sensors to be compatible with standard industrial automation controllers in a relatively low cost and plug and play manner.
Mutual Effects of Fluorine Dopant and Oxygen Vacancies on Structural and Luminescence Characteristics of F Doped SnO2 Nanoparticles
Authors: Wang Xiaolong , Wang Xuan , Di Qingyin , Zhao Hongli , Liang Bo , Yang Jingkai
Published: December 2017

SnO2 and F doped SnO2 (FTO) nanoparticles (NPs) have been synthesized by the hydrothermal method with subsequent annealing at 500 °C. The microstructure and photoluminescence (PL) property of SnO2 and FTO NPs have been investigated, and an assumption model about the luminescence process of FTO NPs has been proposed. All of the SnO2 and FTO NPs possess polycrystalline tetragonal rutile structures, and the average size in the range of 16.5–20.2 nm decreases with the increasing of F doping content. The doping element F is shown a uniformly distribution by electron energy loss spectroscopy (EELS) mapping. The oxygen vacancy concentration becomes higher as is verified by Raman and X-ray photoelectron spectra (XPS). There are three kinds of oxygen chemical states in SnO2 and FTO NPs, in which Oα corresponds to oxygen vacancies. The room temperature PL position is observed to be independent of F doping content. F− may substitute O2− into the SnO2 lattice by generating F O + and one extra e−, which can combine with V O + or V O + + to generate V O 0 or V O + to ensure charge balance.
Equivalence Analysis of Mass and Inertia for Simulated Space Manipulator Based on Constant Mass
Authors: Tian Sihui , Tang Xiaoqiang , Xiang Chengyuan
Published: December 2017

A simulated space manipulator is designed to verify the reliability of the zero-gravity simulation system, which can avoid the risks of experiments involving the space manipulator in this zero-gravity ground system. To achieve similarity between the simulated and actual space manipulators, the mass, barycenter, and inertia must be considered. In this study, a counterweight component is designed and an optimization method is used to match the mass parameters of the simulated joints to those of the space joints. In addition, an equivalence method is used to establish the relationship between the torques of these two manipulators.
The Potential of Indonesian Heterobranchs Found around Bunaken Island for the Production of Bioactive Compounds
Authors: Fisch Katja , Hertzer Cora , Böhringer Nils , Wuisan Zerlina , Schillo Dorothee , Bara Robert , Kaligis Fontje , Wägele Heike , König Gabriele , Schäberle Till
Published: December 2017

The species diversity of marine heterobranch sea slugs found on field trips around Bunaken Island (North Sulawesi, Indonesia) and adjacent islands of the Bunaken National Marine Park forms the basis of this review. In a survey performed in 2015, 80 species from 23 families were collected, including 17 new species. Only three of these have been investigated previously in studies from Indonesia. Combining species diversity with a former study from 2003 reveals in total 140 species from this locality. The diversity of bioactive compounds known and yet to be discovered from these organisms is summarized and related to the producer if known or suspected (might it be down the food chain, de novo synthesised from the slug or an associated bacterium). Additionally, the collection of microorganisms for the discovery of natural products of pharmacological interest from this hotspot of biodiversity that is presented here contains more than 50 species that have never been investigated before in regard to bioactive secondary metabolites. This highlights the great potential of the sea slugs and the associated microorganisms for the discovery of natural products of pharmacological interest from this hotspot of biodiversity.
Analysis of the Comprehensive Tensile Relationship in Electrospun Silk Fibroin/Polycaprolactone Nanofiber Membranes
Authors: Yin Yunlei , Pu Dandan , Xiong Jie
Published: December 2017

The mechanical properties of electrospun nanofiber membranes are critical for their applications. A clear understanding of the mechanical properties that result from the characteristics of the individual fiber and membrane microstructure is vital in the design of fiber composites. In this reported study, silk fibroin (SF)/polycaprolactone (PCL) composite nanofiber membranes were preparedusing an electrostatic spinning technology. The nanofiber orientation distribution (FOD) of the membrane was analyzed using multi-layer image fusion technology, and the results indicated the presence of an approximately uniform distribution of fibers in the electrospun membranes. The relationship between the single nanofiber and the membrane was established by analyzing the geometrical structure of the cell by employing a representative volume element (RVE) analysis method. The mechanical properties of the 272 nm diameter SF/PCL composite fibers were then predicted using the developed model.
Rhodium and Hafnium Influence on the Microstructure, Phase Composition, and Oxidation Resistance of Aluminide Coatings
Authors: Zagula-Yavorska Maryana , Wierzbińska Małgorzata , Sieniawski Jan
Published: December 2017

A 0.5 μm thick layer of rhodium was deposited on the CMSX 4 superalloy by the electroplating method. The rhodium-coated superalloy was hafnized and aluminized or only aluminized using the Chemical vapour deposition method. A comparison was made of the microstructure, phase composition, and oxidation resistance of three aluminide coatings: nonmodified (a), rhodium-modified (b), and rhodium- and hafnium-modified (c). All three coatings consisted of two layers: the additive layer and the interdiffusion layer. Rhodium-doped (rhodium- and hafnium-doped) β-NiAl phase was found in the additive layer of the rhodium-modified (rhodium- and hafnium-modified) aluminide coating. Topologically Closed-Pack (μ and σ) phases precipitated in the matrix of the interdiffusion layer. Rhodium also dissolved in the β-NiAl phase between the additive and interdiffusion layers, whereas Hf-rich particles precipitated in the (Ni,Rh)Al phase at the additive/interdiffusion layer interface in the rhodium- and hafnium-modified coating (c). The rhodium-modified aluminide coating (b) has better oxidation resistance than the nonmodified one (a), whereas the rhodium- and hafnium-modified aluminide coating (c) has better oxidation resistance than the rhodium-modified (b) and nonmodified (a) ones.
Selective Recovery of Mushistonite from Gravity Tailings of Copper–Tin Minerals in Tajikistan
Authors: Sun Lei , Hu Yuehua , Sun Wei , Gao Zhiyong , Tian Mengjie
Published: December 2017

Tajikistan has abundant copper–tin resources. In this study, mineralogical analysis of copper–tin ores from the Mushiston deposit of Tajikistan indicates that tin mainly occurred in mushistonite, cassiterite, and stannite, while copper mainly occurred in mushistonite, malachite, azurite, and stannite. The total grades of tin (Sn) and copper (Cu) were 0.65% and 0.66%, respectively, and the dissemination size of copper–tin minerals ranged from 4 μm to over 200 μm. Coarse particles of copper–tin minerals were partially recovered by shaking table concentrators with a low recovery rate. Based on the mineralogical analysis, flotation recovery was used for the first time on the fine particles of copper–tin minerals, including mushistonite, from shaking table tailings. Single factor flotation experiments, open circuit flotation tests, and closed circuit flotation tests were performed to determine the optimized flotation conditions. Results indicated that benzohydroxamic acid (C6H5CONHOH) and lead nitrate could effectively recover the mushistonite, cooperating with other depressants. The final concentrate contained 13.28% Sn, with a recovery rate of 61.56%, and 18.51% Cu, with a recovery rate of 86.52%. This method proved effective for the exploitation and use of this type of copper–tin resource in Tajikistan.
Response of Ustilago maydis against the Stress Caused by Three Polycationic Chitin Derivatives
Authors: Olicón-Hernández Dario , Uribe-Alvarez Cristina , Uribe-Carvajal Salvador , Pardo Juan , Guerra-Sánchez Guadalupe
Published: December 2017

Chitosan is a stressing molecule that affects the cells walls and plasma membrane of fungi. For chitosan derivatives, the action mode is not clear. In this work, we used the yeast Ustilago maydis to study the effects of these molecules on the plasma membrane, focusing on physiologic and stress responses to chitosan (CH), oligochitosan (OCH), and glycol-chitosan (GCH). Yeasts were cultured with each of these molecules at 1 mg·mL−1 in minimal medium. To compare plasma membrane damage, cells were cultivated in isosmolar medium. Membrane potential (Δψ) as well as oxidative stress were measured. Changes in the total plasma membrane phospholipid and protein profiles were analyzed using standard methods, and fluorescence-stained mitochondria were observed. High osmolarity did not protect against CH inhibition and neither affected membrane potential. The OCH did produce higher oxidative stress. The effects of these molecules were evidenced by modifications in the plasma membrane protein profile. Also, mitochondrial damage was evident for CH and OCH, while GCH resulted in thicker cells with fewer mitochondria and higher glycogen accumulation.