bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between Spinal Instability and Ankle Injuries in Amateur Marathon Runners
Authors: B. Shinde Sandeep , S. Kadam Shivanjali , D. Berde Shreeya , K. Gaonkar Nishant , V. Shinde Ravindra , Kumar Patil Sanjay
Published: April 2023

Background: Marathon running is becoming more popular among middle-aged people who have no prior running experience. Improper or incomplete knowledge increases the risk of injuries in amateur runners. Individuals with spinal instability experience alteration in balance control while walking as well as running which in turn results in asymmetrical bodyweight distribution throughout the lower extremity. This changes the pattern of running leading to injuries of hips, knees, and ankle. Methods: The objective of the study was to correlate spinal instability with ankle injuries in amateur marathon runners. In this study, both male and female amateur marathon runners between the age group of 20 and 45 years with normal body mass index (BMI) were chosen and individuals with the previous surgery as well as degenerative diseases of spine and ankle fractures were ruled out. Spinal instability tests were carried out on amateur marathon runners with symptoms of instability. Subjects were asked questions related to ankle injuries. Outcome measures used were Oswestry Disability Index (ODI) and tests for spinal instability. Results: About 57% of participants were tested positive for the passive lumbar extension test and 42% of participants were tested positive for the prone instability test. There was the presence of ankle pain (68%), ankle swelling (24%), heel pain (60%), blisters (42%), ankle sprain (28%), and strain (26%) in selected participants. There were 68% runners with minimal disability and 32% runners with moderate disability. Conclusion: Amateur marathon runners with spinal instability had the presence of ankle injuries like ankle pain, ankle swelling, heel pain, blisters, ankle sprain, and strain. Based on the test performed and interpretation of the ODI and after correlating spinal instability with ankle injuries, we concluded that spinal instability increases the risk of ankle injuries in amateur marathon runners.
Mid-Day Meal Scheme amidst COVID-19 in India - A Review Based Analysis
Authors: Arora Samridhi , Sharma Kanchan
Published: April 2023

The COVID-19 pandemic posed a crisis like situation in the health and education sector devastating lives of many, particularly children from poor families and putting their future heath on the verge of deterioration. It made hard for today’s man to get a healthy meal a day in pandemic induced economic shutdown. Mid-Day Meal Scheme is also promising a kind of food security to the children for whom it is quite hard to get their daily meals in the crisis. It is really important to determine the drivers and stressors deteriorating health and nutritional conditions since the pandemic is on high. Keeping these in notice, the present study was conducted to have a holistic view of the current condition of the operationalization of the Mid-Day Meal Scheme. It has been tried to know whether the current implementation of Mid-Day Meal Scheme is promising a healthy meal to the children since the operationalization has been changed in context of the COVID-19 scenario. Instead of hot cooked meal, food security allowances, and dry ration are supplied to the beneficiary children. The study was conducted to know that at how much level the beneficiaries actually receiving the benefits of the scheme currently. Some suggestions were also made at the end of the study to make the scheme more available and better in terms of its distribution of services to the beneficiary children.
Minimum Dietary Diversity-Women Score, a Key Indicator of Micronutrient Adequacy and its Association with Iron Status among Pregnant Women: Evidence from a Hospital-Based Cross-Sectional Study
Authors: Saggu Sofia Rani , Prasad Ranu , Verma Anisha
Published: April 2023

A diversified diet is crucial for micronutrient adequacy in a pregnant woman. Iron deficiency Anemia (IDA) is linked to a lack of diversity in diets. The Minimum Dietary Diversity-Women (MDD-W) is a global indicator developed by the FAO to assess diet quality among women of reproductive age. The study seeks to determine the prevalence of MDD scores and its association with sociodemographic factors and iron status among pregnant women. Hospital-based cross-sectional study was conducted among pregnant women at the women’s hospital, Prayagraj, Uttar Pradesh using systematic sampling frame. An enumerator-administered semi-structured interview schedule was used. Hemoglobin levels were assessed and IDA categorized. The prevalence of anemia was 47.4%, of which only 18.1% of women consumed a diverse diet and 81.89% had low MDD-W scores. The mean hemoglobin was 10.82 g/dl, Standard deviation 1.58. Socioeconomic status showed significant correlation to anemia (P = 0.001), and an OR of 1.099 at 95% confidence interval. The high prevalence of IDA and low MDD-W scores proves the need for increased awareness on dietary diversity rates among pregnant women so that micronutrient adequacy can be achieved.
Screening and Evaluation of Bacteriocin Producing L. planatrum and L. pentosus Against Food-Borne Pathogenic Bacteria Isolated from Raw Milk of Cow and Goat from Northern Region of India
Authors: Virk Verinder , Verma Garima , Ram Chand
Published: April 2023

This study focused on inhibitory effect of L. planatrum and L. pentosus isolated from raw milk of cow and goat. The milk samples were taken because of broad spectrum against various food spoilage microorganisms. The spreading of food contaminating micro flora and food-borne pathogens bacteria is threats for food security and public health issues. In the screening of lactic acid bacteria (LAB), out of 18 strains of LAB were isolated from 56 were identified according to their morphological and biochemical characteristics. Whereas, only two isolates (Cm12 and Gm6) showed the bacteriocin producing activity. The cell-free supernatant of these two isolates are protinecous in nature having antimicrobial molecule present in the culture supernatant were found most promising to inhibit all food contaminating bacteria such as Escherichia coli, Staphylococcus aureus, and Bacillus cereus. Thus, further extensive research L. pentosus strains were considered as novel potential bacteria that were further goes for enhancing the longevity of food products.
Amelioration of Rhabdomyolysis-Induced Myoglobinuric Acute Renal Failure by Citrullus lanatus Seeds
Authors: Patil Rupali A. , Tiwari Amit , Amrutkar Sunil V.
Published: April 2023

Citrullus lanatus (Thunb.) (Cucerbitaceae) is a trailing annual herb native to India, Nigeria, and Africa, commonly known as Matsum and Nakai. It thrives in all tropical, subtropical, and warm temperate areas with hot summers. In India, seeds have long been used to treat hypotensive and diuretic effects, as well as kidney stones and urinary passages. This study looked at the effects of a methanol extract of C. lanatus seeds (MCL) on rhabdomyolysis-induced myoglobinuric acute renal failure (ARF) in Wistar rats. Five groups (n = 5) of male Albino Wistar rats weighing 150–200 g were formed. A single intramuscular injection of glycerol (GL) (8 ml/kg) was used to induce ARF. Following GL injection, all animals were sacrificed and blood was collected. Renal function tests utilizing blood urea nitrogen (BUN) and creatinine were performed on freshly separated serum. The right kidney was stored in 10% buffered formalin for histological sectioning, and the amount of lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) activity were all measured. The data were analyzed using a one-way ANOVA and Dunnett’s test. *P > 0.05 was considered statistically significant. Animals pre-treated with MCL (100 and 300 mg kg-1, p.o.) for 7 days before GL dramatically altered and restored serum creatinine, BUN, creatinine clearance, urea clearance, and renal morphology in comparison to the GL-treated group. Oxidative stress markers such as lipid peroxidation, SOD, CAT, and GSH were also dramatically improved. The findings of this study suggest that C. lanatus seed has a possible anti-GL-induced ARF effect, verifying its ethnomedicinal use.
Advent Through the Traditional Medicine Regime for Kshata Guda, that is, Parikartika: A Case Series
Authors: Anand Ajay Kumar , Shinde Archana Kukade , Babar Sanjay
Published: April 2023

One of the most common symptoms in anorectal diseases which encounters in routine clinical practice is Kshata guda, that is, Parikartika, mentions in Ayurved Samhitas. Parikartanam means excessive cutting pain around the anus. Pain is the most important clinical symptoms in this disease. Anal fissure is one of the eloquent causes of pain with per rectum bleeding, sphincter spasm in the anal region at times. Fissure is a crack or a split in the lower end of anal canal. Bailey and Love (1968) have described fissure-in-ano as an elongated ulcer in long axis of anal canal. It is mostly due to constipation. Exact etiology is obscure, one theory is that the fissure-in-ano is caused by overstretching of the epithelial lining of the anal canal by the pressure of a hard fecal mass during defecation against the posterior wall of anorectal junction which is relatively poor supported by musculature on this aspect of the rectum and anal canal. In this case series, the cases are observe symptomatically for the drug healing properties and the objective of the hypothetical parameters shows fruitful results with the application of Yashtimadhu tail (medicated oil) in the management of Parikatika (Fissure-in-ano), leading to non-surgical management of Parikatika (Fissure-in-ano) in very cost-effective way.
RP-HPLC Method Development and Validation for Simultaneous Estimation of Alprazolam and Melatonin in Pharmaceutical Dosage Form
Authors: Rupsi Rupsi , Kumar Rakesh
Published: April 2023

Melatonin a hormone is a major product of the pineal gland. Alprazolam is an anti-anxiety drug that belongs to the benzodiazepines category. The quantity of alprazolam and melatonin had been calculated by the use of a regression equation and the responses were measured at 277 nanometers wavelength using the above-mentioned conditions RP-HPLC simultaneous estimation of Alprazolam and Melatonin has developed a method and determined for validation. The method was estimated as specific and no interference was seen from impurities and excipients. The present study method developed as simple, precise, and accurate for determination and can be further used for the analysis of Alprazolam and Melatonin for dosage formulation.
Ksheeravasthi in AVN Femoral Head – A Case Study
Authors: Deepa M. S. , V Aswathi Nair
Published: April 2023

A 41-year-old male patient radiologically diagnosed as a case of avascular necrosis of head of both femur with Grade 2 of Ficat and Arlet classification, presented with the following chief complaints of pain in both hip joints, more on left side, of Harris Hip score was 66 and associated with decreased range of movements with slight limping. This presentation was correlated with Asthikshayaja vyadhi and treated accordingly. Initially, patient had been administered dipana and pacana followed by snehapana and koshtasodhana by virechana. Further panchathikthaka ksheera vasthi (medicated enema prepared with milk and ghee) was administered. This resulted with improvement of Harris hip score to 91.
Predictors of Adverse Events Following Immunization Reporting amongst Healthcare Workers in Jigawa State, Northern Nigeria, 2022
Authors: Uba Belinda Vernyuy
Published: March 2023

An adverse event following immunization (AEFI) is any untoward medical occurrence that follows immunization and does not necessarily have a causal relationship with the usage of the vaccine. Reporting of AEFI is suboptimal amongst healthcare workers (HWs). This study aimed to determine predictors of HW’s reporting of AEFI. A descriptive cross-sectional study was conducted among HWs in selected health facilities (HFs) in Jigawa State using an open data kit self-administered questionnaire to collect data on socio-demographic characteristics, training, knowledge, and their practices on AEFI reporting. Analysis was conducted using Statistical Package for Social Sciences (SPSS) for frequencies, proportions, and associations using bivariate analysis and multivariate analysis using logistic regression to determine predictors of AEFI reporting with statistical significance set at p<0.05 and 95% confidence interval. Of the 400 respondents, 280 (70%) respondents had good knowledge of AEFI, 328(82%) sends routine AEFI reports and of 212 (53%) who recently encountered an AEFI, 174 (82.1%) exhibited some good reporting practices. Female gender (AOR 0.46, p=0.035), full-time employees (AOR 0.227, p=0.019), a recent encounter with an AEFI (AOR 3.087, p=0.007) and being trained on AEFI (AOR 5.54, p=0.011), reporting to elicit training (AOR 2.70, p=0.031) were predictors of routine reporting from health facility and reporting an encountered AEFI respectively. Overall, gender, employment status, being trained, and recent AEFI encounter to elicit training were predictors of AEFI reporting. To improve reporting of AEFI, there is a need to engage and train health workers on AEFI surveillance. Keywords: Adverse events following immunization, Knowledge, Practice, Predictors, Reporting.
Barriers and Facilitators to Integration of Social Determinants into Clinical Practice in Hospitals in Uganda
Authors: Emmanuel Higenyi
Published: March 2023

Integration of social determinants into clinical practice is an emerging attractive phenomenon because of its potential benefits to the health system and patients however inadequate understanding of the barriers and facilitators poses immense challenges in designing programs and interventions aimed at enhancing integration of social determinants into clinical practice. This study investigated the barriers and facilitators to integration of social determinants into clinical practice in hospitals in Uganda. Data was collected from 21 key informants using a key informant guide that covered various aspects of integration of social determinants into clinical practice. The study identified barriers and facilitators at institutional and health-worker associated barriers. These barriers were at patient, departmental and community levels. There were similarities and differences in the barrier’s ad facilitators observed in this study and those articulated in literature. More so this study revealed some unique barriers and facilitators. The study confirmed existence of barriers and facilitators to integration of social determinants into clinical practice in hospitals in Uganda. Although in-depth interviews were conducted it was not possible to eliminate self-report bias Keywords: Barriers, Facilitators, Social determinants, Integration, Hospitals.
Daily streamflow prediction based on the long short-term memory algorithm: a case study in the Vietnamese Mekong Delta
Authors: Nguyen Huu Duy , Van Chien Pham , Nguyen Quoc-Huy , Bui Quang-Thanh
Published: April 2023

The objective of this study is the development of a state-of-the-art method based on long short-term memory (LSTM), support vector machine (SVM), and random forest (RF) to predict the streamflow in the Mekong Delta in Vietnam, an area crucial to Vietnam's food security. Water level and flow data from 2014 to 2018 at the Tan Chau station and Can Tho (on the Hau River) were used as the input data of the prediction model. Three different ranges of data – from the preceding 4, 8, and 12 days – were used to predict streamflow for both 1 and 7 days ahead, resulting in six individual predictions. Various statistical indices, namely root-mean-square error, mean absolute error (MAE), and the coefficient of determination (R2), were used to assess the predictive ability of the model. The results showed that the SVM and random forest models were successful in improving the performance of the LSTM model, with R2 > 80%. For a prediction of 1 day ahead, the proposed models gave an R2 value of 2–5% higher than a prediction of 7 days ahead. These results highlighted that LSTM is a robust technique for characterizing and predicting time series behaviors in hydrology applications.
Sustainable Green Synthesis of Pyrimidine Derivatives: Review on
Multicomponent Synthesis, Catalysts and Techniques
Authors: Eid Elshimaa Mohmed
Published: March 2023

“The founder of green chemistry explains how chemicals manufacturing must change to support a sustainable future.” In this review, Green chemistry is considered in the synthesis of heterocycles compounds containing Pyrimidine nuclei using different catalyzes, solvents, and techniques for the synthesis of pyrimidine derivatives that achieve sustainabil-ity. The mentioned fused heterocycles are classified according to the type of ring system. The yield of the target molecules reported in the review is given in the reaction's last step.
Diabetes and TB: Confluence of Two Epidemic and Its Effect on Clinical
Presentation
Authors: Dhamotharaswamy Kumudha , Selvaraj Hemalatha , Lakshmanaperumal Padmashree , R. Harsha , Sasankan Anuja S. , Thangavelu Prabha , K. Menaka , Thangavel Sivakumar
Published: March 2023

Background:

Tuberculosis (TB) has become a rising concern in low-income countries,
particularly in those with Human Immuno Deficiency Virus (HIV) epidemics, and type 2 diabetes
has emerged as a significant global chronic health problem, owing to increases in obesity, lifestyle
changes, and ageing populations. Diabetes has been identified as a major risk factor for the development
of TB. Despite the fact that diabetes imparts a substantially lower risk of TB (3-fold) as
compared to HIV (>20-fold), in communities where the number of DM patients is high, the contribution
of diabetes to TB might be bigger than HIV.

Methods:

This review will focus on the link between TB and diabetes, which is now one of the
most important topics for physicians since diabetes impacts the clinical presentation and outcome
of TB and vice versa.

Results:

Though TB is more common in type 1 diabetes, the extent of the problem in type 2 diabetes
should be taken into account with equal care, as type 2 diabetes affects a substantially higher
number of individuals.

Conclusions:

Diabetes patients are more vulnerable to infections because of their impaired immune
systems. Increased glucose level leads to a rise in the infection status among TB patients and
also leads to a rise in various complications. Extensive and increased screening for both TB and
DM over years can help diagnose disease priorly and help in better management. TB, when diagnosed
in its early stages, can be easily eradicated.
Acetyl-L-carnitine and Amyotrophic Lateral Sclerosis: Current Evidence
and Potential use
Authors: De Marchi Fabiola , Venkatesan Sakthipriyan , Saraceno Massimo , Mazzini Letizia , Grossini Elena
Published: March 2023

Background:

The management of neurodegenerative diseases can be frustrating for clinicians,
given the limited progress of conventional medicine in this context.

Aim:

For this reason, a more comprehensive, integrative approach is urgently needed. Among various
emerging focuses for intervention, the modulation of central nervous system energetics, oxidative
stress, and inflammation is becoming more and more promising.

Methods:

In particular, electrons leakage involved in the mitochondrial energetics can generate reactive
oxygen-free radical-related mitochondrial dysfunction that would contribute to the etiopathology
of many disorders, such as Alzheimer's and other dementias, Parkinson's disease, multiple sclerosis,
stroke, and amyotrophic lateral sclerosis (ALS).

Results:

In this context, using agents, like acetyl L-carnitine (ALCAR), provides mitochondrial support,
reduces oxidative stress, and improves synaptic transmission.

Conclusion:

This narrative review aims to update the existing literature on ALCAR molecular profile,
tolerability, and translational clinical potential use in neurodegeneration, focusing on ALS.
Mammalian Target of Rapamycin (mTOR) Signalling Pathway-A Potential
Target for Cancer Intervention: A Short Overview
Authors: Basnet Rajesh , Bahadur Basnet Buddha , Gupta Radheshyam , Basnet TilBahadur , Khadka Sandhya , Shan Alam Md
Published: March 2023

Background:

The mammalian role of the rapamycin (mTOR) pathway is the practical nutrient-sensitive regulation of animal growth and plays a central role in physiology, metabolism, and common diseases. The mTOR is activated in response to nutrients, growth factors, and cellular energy. The mTOR pathway activates in various cellular processes and human cancer diseases. Dysfunction of mTOR signal transduction is associated with metabolic disorders, cancer for instance.

Objective:

In recent years, significant achievements envisaged in developing targeted drugs for cancer. The global impact of cancer continues to grow. However, the focus of disease-modifying therapies remains elusive. The mTOR is a significant target in cancer to be considered for mTOR inhibitors, even though the costs are high. Despite many mTOR inhibitors, potent, selective inhibitors for mTOR are still limited. Therefore, in this review, the mTOR structure and protein-ligand interactions of utmost importance to provide the basis for molecular modelling and structure-based drug design are discussed.

Conclusion:

This review introduces the mTOR, its crystal structure, and the latest research on mTOR.Besides, the role of mTOR in cancer, its function, and its regulation are reviewed. In addition, the mechanistic role of mTOR signalling networks in cancer and interaction with drugs that inhibit the development of mTOR and crystal structures of mTOR and its complexes are explored. Finally, the current status and prospects of mTOR-targeted therapy are addressed.
Indium Metal-Mediated Reactions in Water: Diverse Synthesis of
Important Organic Compounds
Authors: Kamboj Monika , Bajpai Sangeeta , Pandey Garima , Banik Bimal Krishna
Published: March 2023

Ecofriendly Indium catalyzed synthesis of organic compounds finds various applica-tions in health sectors, electronics, semiconductors, and many more. An efficient co-catalyst and oriented catalyst behavior of Indium has become a choice for many organic transformations. Its compatibility with water, showing nontoxic and nonreactive action, proceeds the reactions with ease. Focus on Indium metal-mediated important organic transformations in water, is visible dur-ing the last decades, resulting in diverse organic compounds with excellent yields This present mini-review highlights some important indium metal-mediated reactions in water, for the diverse synthesis of important organic compounds.
Gingival and Periodontal Diseases in Children
Authors: Kumar Kulkarni Vinaya , Dixit Mala , Balasubramanian Shruti , Jetpurwala Abdulkadeer
Published: March 2023

Pediatric population experiences a wide array of gingival and periodontal
diseases. Studies have shown that gingivitis is almost universally prevalent among
pediatric patients. However, lesser attention is given to periodontitis in children owing
to the shorter life span of primary dentition. Periodontal assessment must be
incorporated into the routine oral examination of the child since prompt diagnosis plays
a crucial role in successfully managing periodontal conditions. Severe periodontal
disease may also occur among children with concomitant systemic conditions.
Therefore, the presence of a destructive periodontal condition may serve as an early
indicator of an underlying systemic condition, and the dentist may be the first to notice
such a condition. Hence, a thorough medical evaluation should be performed for
children exhibiting severe periodontitis, especially for cases that appear resistant to
therapy, to determine the systemic causes of the condition. Although at present, there is
increased awareness regarding periodontal health and treatment modalities, it is
restricted to adults with a negligible focus on children. Intraoral assessment of children
is cecentredroundan examination of hard tissues with minimal focus on the health of
soft tissue. Hence, this chapter enlightens various gingival and periodontal conditions
and the importance of overall health during childhood. 
adoption of environmental management accounting
Authors: Wedasuar Putu Rany , Sudana I Made , Yintayani Ni Nyoman
Published: April 2023

The use of environmental management accounting concepts for companies encourages the ability to minimize the environmental problems it faces. The same is the case with five-star hotel companies in the Nusa Dua area. this study aims to examine the adoption of EMA in the hotel industry in Nusa Dua and the Adoption of Environmental Management Accounting (EMA) among hotel companies in Nusa Dua. This research is qualitative research. Data collection is done by survey, interview, and observation. Data analysis used interactive model of analysis from Miles and Huberman. The findings that can be seen are scale of environmental costs and contemporary management accounting practices affect the implementation of environmental management accounting in the hotel industry. The company considers that the implementation of Activity Based Costing provides better insight into the structure of hotel expenses.
Modeling of a Positive Case of Covid-19 Through Regressive Objective Regression Without Doing PCR
Authors: González Melba Zayas
Published: April 2023

Currently, new technological advances in biomedicine make the creation of multidisciplinary teams of vital importance. These groups can be made up clinicians, epidemiologists, mathematicians, statisticians, computer scientists, biologists, among others, all together they can achieve an accurate prediction of infectious diseases and thus draw up the appropriate strategies by the competent authorities. The fundamental objective of this work is to obtain, through Regressive Objective Regession (ROR), the modeling of the next positive case that arrived with COVID-19 without performing PCR at the “Marta Abreu” Trashing Polyclinic in the city of Santa Clara. In this work, daily data were used from January to March corresponding to the year 2021 of the number of Covid-19 cases in the “Marta Abreu” Teaching Polyclinic in the city of Santa Clara, in the province of Villa Clara, Cuba, a total of 3294 cases of them 58 positive, of which they are assigned in the database an order number (No) according to how they were registered in the database. In the short-term modeling, the model was assigned to 19.7% with an error of0.12 the dichotomous variables, saw tooth and inverted saw tooth, and the risk returned in 1.3 and 12 cases, the trend is negative and not significant. The ROR modeling of predictions obtained give very significant results for the study of the COVID-19 pandemic at the Marta Abreu Teaching Polyclinic. With the results of the study, the authorities are provided, and in fact they are already doing so, with information on the short-and medium-term behavior of variables of great interest to understand the expansion of SARS-CoV2, which could be used for decision-marking.
Use of a Smartphone-Based Medication Adherence Platform to Improve Outcomes in Uncontrolled Type 2 Diabetes Among Veterans: Prospective Case-Crossover Study
Authors: Rai Amneet , Riddle Mark , Mishra Rajendra , Nguyen Nhien , Valine Kelly , Fenney Megan
Published: April 2023

Background

Medication nonadherence is a problem that impacts both the patient and the health system.

Objective

The objective of this study was to evaluate the impact of a novel smartphone app with patient-response-directed clinical intervention on medication adherence and blood glucose control in noninsulin-dependent patients with type 2 diabetes mellitus (T2DM).

Methods

We enrolled 50 participants with T2DM not on insulin with smartphones from a rural health care center in Northern Nevada for participation in this case-crossover study. Participants underwent a standard of care arm and an intervention arm. Each study arm was 3 months long, for a total of 6 months of follow-up. Participants had a hemoglobin A1c (HbA1c) lab draw at enrollment, 3 months, and 6 months. Participants had monthly “medication adherence scores” (MAS) and “Self-Efficacy for Appropriate Medication Use Scale” (SEAMS) questionnaires completed at baseline and monthly for the duration of the study. Our primary outcomes of interest were the changes in HbA1c between study arms. Secondary outcomes included the evaluation of the difference in the proportion of participants achieving a clinically meaningful reduction in HbA1c and the difference in the number of participants requiring diabetes therapy escalation between study arms. Exploratory outcomes included the analysis of the variation in medication possession ratio (MPR), MAS, and SEAMS during each study arm.

Results

A total of 30 participants completed both study arms and were included in the analysis. Dropouts were higher in participants enrolled in the standard of care arm first (9/25, 36% vs 4/25, 16%). Participants had a median HbA1c of 9.1%, had been living with T2DM for 6 years, had a median age of 66 years, and had a median of 8.5 medications. HbA1c reduction was 0.69% in the intervention arm versus 0.35% in the standard of care arm (P=.30). A total of 70% (21/30) of participants achieved a clinically meaningful reduction in HbA1c of 0.5% in the app intervention arm versus 40% (12/30) in the standard of care arm (odds ratio 2.29, 95% CI 0.94-5.6; P=.09). Participants had higher odds of a therapy escalation while in the standard of care arm (18/30, 60% vs 5/30, 16.7%, odds ratio 4.3, 95% CI 1.2-15.2; P=.02). The median MPR prior to enrollment was 109%, 112% during the study’s intervention arm, and 102% during the standard of care arm. The median real-time MAS was 93.2%. The change in MAS (1 vs –0.1; P=.02) and SEAMS (1.9 vs –0.2; P<.001) from baseline to month 3 was higher in the intervention arm compared to standard of care.

Conclusions

A novel smartphone app with patient-response-directed provider intervention holds promise in the ability to improve blood glucose control in complex non–insulin-dependent T2DM and is worthy of additional study.
Understanding What Drives Long-term Engagement in Digital Mental Health Interventions: Secondary Causal Analysis of the Relationship Between Social Networking and Therapy Engagement
Authors: O'Sullivan Shaunagh , van Berkel Niels , Kostakos Vassilis , Schmaal Lianne , D'Alfonso Simon , Valentine Lee , Bendall Sarah , Nelson Barnaby , Gleeson John F , Alvarez-Jimenez Mario
Published: April 2023

Background

Low engagement rates with digital mental health interventions are a major challenge in the field. Multicomponent digital interventions aim to improve engagement by adding components such as social networks. Although social networks may be engaging, they may not be sufficient to improve clinical outcomes or lead users to engage with key therapeutic components. Therefore, we need to understand what components drive engagement with digital mental health interventions overall and what drives engagement with key therapeutic components.

Objective

Horyzons was an 18-month digital mental health intervention for young people recovering from first-episode psychosis, incorporating therapeutic content and a private social network. However, it is unclear whether use of the social network leads to subsequent use of therapeutic content or vice versa. This study aimed to determine the causal relationship between the social networking and therapeutic components of Horyzons.

Methods

Participants comprised 82 young people (16-27 years) recovering from first-episode psychosis. Multiple convergent cross mapping was used to test causality, as a secondary analysis of the Horyzons intervention. Multiple convergent cross mapping tested the direction of the relationship between each pair of social and therapeutic system usage variables on Horyzons, using longitudinal usage data.

Results

Results indicated that the social networking aspects of Horyzons were most engaging. Posting on the social network drove engagement with all therapeutic components (r=0.06-0.36). Reacting to social network posts drove engagement with all therapeutic components (r=0.39-0.65). Commenting on social network posts drove engagement with most therapeutic components (r=0.11-0.18). Liking social network posts drove engagement with most therapeutic components (r=0.09-0.17). However, starting a therapy pathway led to commenting on social network posts (r=0.05) and liking social network posts (r=0.06), and completing a therapy action led to commenting on social network posts (r=0.14) and liking social network posts (r=0.15).

Conclusions

The online social network was a key driver of long-term engagement with the Horyzons intervention and fostered engagement with key therapeutic components and ingredients of the intervention. Online social networks can be further leveraged to engage young people with therapeutic content to ensure treatment effects are maintained and to create virtuous cycles between all intervention components to maintain engagement.

Trial Registration

Australian New Zealand Clinical Trials Registry: ACTRN12614000009617; https://www.australianclinicaltrials.gov.au/anzctr/trial/ACTRN12614000009617
Metaphor in Foreign Language Learning and Teaching and its Implications
Authors: Miao Zhu
Published: March 2023

Metaphor, as a conceptual and cognitive tool, plays an important role in language learning and teaching. Based on the related research on metaphor, this paper discusses the performance of metaphor in foreign language learning and teaching and the relationship between them. This paper discusses the relationship between metaphor and foreign language learning from three aspects: vocabulary, foreign language communicative competence and culture. Finally, this paper summarizes the implications of metaphor for foreign language teaching: developing metaphoric awareness, strengthening metaphoric competence and using metaphor analysis in teaching evaluation.
FRANSA BİSİKLET TURU MAYO KLASMANINDAKİ SPORCULARIN GENEL KLASMAN SIRALAMASIYLA İLİŞKİSİNİN ÇEŞİTLİ DEĞİŞKENLERLE KARŞILAŞTIRILMASI
Authors: SATILMIŞ Nuray , AKBAŞ Duran , BAYRAKDAR Akan , BAYRAKTAR Işık
Published: March 2023

Fransa Bisiklet Turunu dünyanın en popüler yarışlarından birisi olması ve mayo klasmanlarında gözlemlenen literatür eksikliğinden bu çalışmanın yapılmasına ihtiyaç duyulmuştur. Bu çalışmanın amacı 2000-2022 yılları arasındaki Fransa Bisiklet Turunda beyaz mayo, kırmızı mayo ve yeşil mayo klasmanındaki ilk üç (toplam; altmış dokuz) sporcunun müsabaka sonuçlarının, genel klasman sıralamasıyla ilişkisinin çeşitli değişkenlere göre incelenmesidir. Çalışmadaki sporcuların yarış sonuçları Procyclingstats ve Tour de France sitelerinden alınmıştır. Her mayo klasmanı için ilk üç sırada yer alan 69 sporcunun genel klasmandaki sıraları yaş, sıra, hız değişkenleriyle karşılaştırılmıştır. Normal dağılım sergilemeyen verilerin karşılaştırılmasında Kruskal Wallis ve Spearman korelasyon testleri kullanılmıştır. Araştırma sonuçlarında beyaz mayo klasmanındaki ilk üç sporcunun genel klasmandaki ortalama sıraları arasında anlamlı farklılık tespit edilmiştir. Beyaz mayo klasmanındaki ilk üç sporcunun “genel klasman sıraları” ile arasında pozitif yönde yüksek düzeyde (rho=0,726), yeşil mayo klasmanındaki (puana dayalı) ilk üç sporcunun “genel klasman sıraları ” ve “ortalama hız” arasında negatif yönde orta düzeyde (rho=-0,477), kırmızı mayo klasmanındaki (puana dayalı) ilk üç sporcunun “genel klasman sıraları” ve “ortalama hız” arasında negatif yönde orta düzeyde (rho=-0,429) ve “genel klasman sırası” ile “genel klasman yaş” arasında pozitif yönde düşük düzeyde bir ilişki (rho=0,29), olduğu tespit edilmiştir. Kırmızı ve yeşil mayo klasman sıralamaları puanla ve beyaz mayo klasmanı sporcuların bitirme sürelerine göre belirlenmektedir. Kırmızı mayo klasmanındaki kişiler en iyi yokuş çıkan sporcular olduğu için bu kişilerin yaş faktörüyle düşük düzeyde ilişkili olduğu sonucuna varılmıştır.
Práticas comunicativas e pesquisa científica no cárcere: experiências e desafios interpostos pela pandemia
Authors: Ribeiro de Oliveira Josilene , Oliveira de Brito Suelen
Published: April 2023

A presente obra é fruto do trabalho colaborativo horizontal de iniciação à pesquisa no cárcere. Não é um manual de pesquisa, mas sim o resultado de uma revisão de literatura e uma abordagem etnográfica de pesquisa de campo. Trabalhos que só foram possíveis fazer por ter no grupo pessoas comprometidas, éticas e engajadas em fazer pesquisa científica com seriedade, mesmo em meio a uma pandemia e às restrições por ela geradas ao trabalho empírico.
Phenomenon and Concept of EMANCIPATION
Authors: Ledeneva Valentina V. , Kovina Tamara P. , Fesenko Emiliya Ya. , Bazhenova Alina P.
Published: April 2023

The study of the conceptual sphere is a field of linguistics which is closely related to the study of culture, the mentality of a particular linguistic personality or society of a certain epoch, the people as a carrier of mentality. Research in this area is important not only in synchrony, but also in diachrony, due to the historical variability of cultural codes, the volume and content of language resources as the means of representation of concepts, the evolution of the social substratum of language in the developing world. This determines the relevance of addressing the phenomenon of emancipation, since it is associated with shifts in social (primarily legal) relations of various kinds, in culture, rightly regarded by science as having humanitarian value. The aim of the study is to characterize from a linguistic point of view the content features of the concept of EMANCIPATION, which are determined by social trends, the passionarity of the epoch, the intentions of individuals evaluating the phenomenon, taking into account the noticeable stability of the core of Abstract semantics of its most important representative - the word emancipation. The research is carried out from anthropocentric positions, in synchronous-diachronic terms, using a set of methods: descriptiveanalytical, elements of component analysis, comparative analysis, synthesis, methods of cognitive linguistics, sociolinguistic (survey). The main material was the data of the National Corpus of the Russian Language (Ruscorpora), namely, the contexts of a sample of documents presented in it from different eras with the word emancipation in various grammatical forms. The research has shown that the word emancipation in the Russian conceptual sphere is consistently represented primarily by the concept, the semantic dominant of which is formed by ‘woman’ ( the phenomenon of women’s emancipation, female emancipation ), so that we can talk about its prominence in the Russian culture with this name: EMANCIPATION. Artistic and journalistic works of Russian writers, including “women’s prose”, contributed to the isulation of this concept. The word emancipation, used with other pragmatic attitudes, performs the function of one of the verbalizers of the concepts of related spheres: INDEPENDENCE, FREEDOM of CREATIVITY. The practical application of this material can be associated with its use in university linguistic courses, in the study of terminology, in lexicography, in literary studies, in explaining the scope of the term emancipation in the official business style, modern legal discourse.
Microhabitat partitioning between sympatric intertidal fish species highlights the importance of sediment composition in gravel beach conservation
Authors: Wagner Maximilian , Benac Čedomir , Pamić Maja , Bračun Sandra , Ladner Martin , Plakolm Pia , Koblmüller Stephan , Svardal Hannes , Brandl Simon
Published: April 2023

1 Gravel beaches in the Mediterranean ecoregion represent an
economically important and unique habitat type. Yet, burgeoning tourism,
intensive coastal development and artificial nourishment of beaches may
jeopardize their ecological communities. To date, species that reside on
gravel beaches and the consequences of beach alterations are poorly
understood, which hampers the development of a sustainable coastal
tourism industry along the region’s shorelines. 2 Using a simple
collection method based on dredging buckets through the intertidal
section of beaches, we quantified the microhabitat association of two
sympatric clingfish species in the genus Gouania at seven natural and an
artificial gravel beach based on sediment characteristics. We
hypothesized that slender (G. pigra) and stout (G. adriatica)
morphotypes would partition interstitial niche space based on sediment
size, which may affect the vulnerability of the species to changes in
gravel beach composition due to coastal development. 3 We detected
substantial differences in gravel composition within and among the
sampled beaches which suggests scope for microhabitat partitioning in
Gouania. Indeed, we found significant relationships between species
identity and the presence/absence and abundance of individuals in hauls
based on their positioning on PC1. 4 Our results suggest that
modifications of gravel beaches through coastal development, including
beach nourishment, intensifying coastal erosion, or artificial beach
creation, may have detrimental consequences for the two species if
sediment types or sizes are altered. We posit that, given the simplicity
and efficacy of our sampling method and the sensitivity of Gouania
species to prevailing gravel composition, the genus could serve as an
important indicator for gravel beach management in the Mediterranean
ecoregion.
Estudio comparativo entre México y Colombia de las prácticas docentes en contextos rurales en tiempos de la pandemia covid-19
Authors: González Fernández María Obdulia , Vargas Mesa Enid Daniela , Martínez Martínez Gloria , Arias López José Luis
Published: April 2023

La educación rural latinoamericana se ha caracterizado por una serie de inequidades; no fue la excepción durante el periodo de la pandemia covid-19. Por ello, el objetivo de este trabajo es describir las prácticas de los maestros rurales mexicanos y colombianos e indagar en los principales retos y aciertos de las estrategias de enseñanza. El estudio es de naturaleza cualitativa descriptiva, basado en entrevistas con 10 maestros rurales de nivel básico de Colombia y México. El guión de entrevista fue validado por juicio de expertos utilizando la razón de validez de contenido. Mientras que la elección de la muestra fue por conveniencia. Se utilizó análisis de contenido para interpretar los datos utilizando el software MAXQDA 2022. Los resultados muestran una inequidad en el acceso a las tecnologías, servicios de internet, así como un aumento del rezago educativo. Las estrategias didácticas se caracterizaron por guías impresas y seguimiento asincrónico a través de plataformas como WhatsApp. Uno de los aciertos metodológicos fue el asesoramiento personalizado in situ. Los docentes expresan el desarrollo de habilidades digitales, comunicación y diseño de estrategias para el trabajo remoto en escuelas rurales.
The Use of A Static Mixer for The Coagulation Unit in The Duren Seribu II Water Treatment Plant
Authors: Sari Sheryline Putri Chandra , Kusumadewi Riana Ayu , Winarni Winarni
Published: April 2023

In the drinking water treatment plant involves a significant component i.e., coagulation, which distributed coagulants vastly and equally through rapid stirring for destabilizing colloids and suspended particles in the raw water. In water treatment plants, coagulation units are often classified into mechanical and hydraulic coagulation. This study aimed to discover the use of and in-line static mixers as coagulation in designing the Duren Seribu II Drinking Water Treatment Plant (WTP). The design criteria for coagulation unit in Duren Seribu II WTP was determined by comparing several data obtained from literature studies and evaluation of the existing conditions of Duren Seribu I WTP. Duren Seribu I WTP was evaluated by direct measurement in the field. From the results of data analysis, the design criteria appropriate for Duren Seribu II WTP, the G value is 2078.07 sec-1, the detention time (td) is 4 sec, and the G.td value is 8352.19.
Sustainable Development of Vietnam Stock Market
Authors: Vung Dinh Thi , Ha Nguyen Thi Thu
Published: March 2023

Vietnam's stock market is considered to be potential, developing strongly, and is an important capital channel of the economy. Through analyzing the collected data, it can be seen that the development of Vietnam's stock market such as capitalization value, newly added products, increased number of listed companies. Besides, with data analysis and processing methods, the research also shows that Vietnam's stock market is facing significant challenges such as lack of transparency, unsustainability. The study has suggested some solutions to improve the operational efficiency of Vietnam's stock market in the coming period.
Personal Construction of the “Ego”: A Prenatal Discovery of the Body
Authors: Persoons Dominique J. , Bryde Jette I.
Published: March 2023

For Sigmund Freud, founder of psychoanalysis, the Unconscious is characterized by the fact that it is born from the repression of impulses. For Carl Jung, on the other hand, the Unconscious is made up of everything that is not conscious. According to Jung: “It is inherent to reality and to the communication of the conscious with the Unconscious, and allows the becoming of the individual”. He called it “collective” because its pictorial manifestations, the archetypes, were common to all human beings. For 20 years he searched, with the physicist Wolfgang Pauli, for an extra-personal origin of the Unconscious, called “synchronicity”. The study of near-death experiences sheds new light on this question: the last image the dying man/woman sees would be himself a few weeks before his birth. The ego is believed to be built in the fetal stage around the discovery of the body, and to remain unchanged until brain death. Personalism would describe the fetus’ access to self-consciousness by discovering his body.
Meaning of Entrepreneurial Journalism Among Journalists of Mass Media Companies
Authors: Vazza Agung Pragitya , Mulyana Ahmad
Published: March 2023

The development of communication technology allows journalists to publish journalistic content independently through personal accounts on social media and sharing platforms. Independent publication allows journalists to earn additional income exceeding their official salary as journalists in media companies. This practice indicated as entrepreneurial journalism often blurs the boundaries between journalistic and commercial aspects. This study aims to reveal the meaning of entrepreneurial journalism among journalists of mass media companies. This study uses the social construction of technology (SCoT) theory with Alfred Schutz's phenomenological method and a qualitative approach. The study showed that journalists publish news through social media accounts and sharing platforms in various forms and content formats. The journalists practice entrepreneurial journalism because their skills support their passion for mastering technological devices. Besides, they also achieve self-satisfaction from working independently. Journalists regard entrepreneurial journalism as a side job while upholding the journalistic aspect rather than the economic reason. Expectations and opportunities to earn additional income do not attract journalists practicing entrepreneurial journalism to ignore journalistic values and norms. Journalists prioritize creating and publishing quality news content by following the Journalistic Code of Ethics. Entrepreneurial journalism tends to be interpreted by journalists personally as a form of repositioning and self-actualization during social life.