bluuebunny/crossref_metadata_2025 huggingface dataset:
From Concept to Market: Ensemble Predictive Model for Research Project Crowdfunding Readiness
Authors: Ionica Andreea Cristina , Cseminschi Stanislav , Leba Monica
Published: November 2024

This study introduces an ensemble model that integrates random forest, gradient boosting, and logistic regression to predict the success of crowdfunding campaigns. Our research develops a novel set of metrics that assess the developmental stage of research projects, facilitating the transition from concept to market-ready product. Utilizing data from multiple sources, including Kaggle’s dataset of Kickstarter and Indiegogo projects and a proprietary dataset tailored to our study, the model’s performance was evaluated against traditional implementations of random forest and gradient boosting. The results demonstrate the ensemble model’s superior performance, achieving an accuracy of 98.94% and an F1 score of 98.81%, significantly outperforming the individual models, showing the best accuracies of around 91% for random forest and lower scores for gradient boosting. This enhancement in predictive power allows for optimized resource allocation and strategic planning in project development, thereby increasing the likelihood of crowdfunding success. This approach streamlines the process of bringing innovative ideas to final products, while at the same time offering a methodologically advanced tool for stakeholders to enhance their campaign strategies effectively.
Longitudinal Comparison of Three T-Cell Assays and Three Antibody Assays Against SARS-CoV-2 Following Homologous mRNA-1273/mRNA-1273/mRNA-1273 and Heterologous ChAdOx1/ChAdOx1/BNT162b2 Vaccination: A Prospective Cohort in Naïve Healthcare Workers
Authors: Lee Hyeyoung , Ko Geon Young , Lee Jihyun , Bae Hyunjoo , Ryu Ji Hyeong , Jung Jin , Kang Hyunhye , Lee Raeseok , Lee Dong-Gun , Oh Eun-Jee
Published: November 2024

Background: Cellular and humoral immunity are key to the immune response against SARS-CoV-2, but the comparability and correlation across different assays remain underexplored. This study compares three T-cell and three antibody assays in two vaccine groups. Methods: This prospective longitudinal cohort study involved 46 naïve healthcare workers: a total of 11 in the homologous mRNA-1273 group (three doses) and 35 in the heterologous ChAd group (two ChAd doses followed by a BNT booster). Blood samples were collected at five time points. Cellular immunity was assessed using ELISPOT and two commercial interferon-gamma release assays: (IGRA)-QuantiFERON SARS-CoV-2 (QF) and Covi-FERON ELISA (CoVF). Humoral immunity was evaluated using total and IgG antibody assays and a surrogate virus neutralization test. Results: The mRNA-1273 group exhibited stronger and more consistent responses than the ChAd group. The correlations between ELISPOT and IGRA varied from weak to moderate (ρ = 0.300–0.410), while QF-IGRA and CoVF-IGRA showed stronger correlations (ρ = 0.700–0.737). The ELISPOT assay showed substantial agreement with QF [Ag2]-IGRA (k = 0.697–0.774) and CoVF [O-sp]-IGRA (k = 0.641–0.718), and an 80.4% agreement rate (k = 0.608) was found between the QF [Ag2]- and CoVF [O-sp]-IGRA tests. Three antibody assays demonstrated very strong correlations with each other and substantial to near-perfect agreement with ELISPOT (k = 0.866–0.949), QF [Ag2]-IGRA (k = 0.807–0.831), and CoVF [O-sp]-IGRA (k = 0.753–0.777). Conclusions: SARS-CoV-2-specific cellular and antibody responses vary by platform and vaccine type, highlighting the importance of measuring both T-cell and B-cell responses using multiple assays to comprehensively assess immune status.
A Statistical Model to Predict Protection Against Infant Respiratory Syncytial Virus Disease Through Maternal Immunization
Authors: Cai Bing , Chen Yili , Agosti Yasmeen , Schmoele-Thoma Beate , Koury Kenneth , Jansen Kathrin U. , Gruber William C. , Dormitzer Philip R. , Swanson Kena A.
Published: November 2024

Background/Objectives: Respiratory syncytial virus (RSV) is the leading cause of severe respiratory disease in infants worldwide. Maternal immunization to protect younger infants is supported by evidence that virus-neutralizing antibodies, which are efficiently transferred across the placenta from mother to fetus, are a primary immune mediator of protection. In maternal RSV vaccine studies, estimates of correlates of protection are elusive because many factors of maternal–fetal immunobiology and disease characteristics must be considered for the estimates. Methods: We developed statistical models that aims to predict vaccine efficacy (VE) in infants following maternal immunization by including quantifiable covariates of the antibody titer distribution of the mother (pre- and post-immunization), the transplacental transfer ratio of IgG antibodies, the rate of antibody decay, and RSV disease incidence rate, all of which are season- and time-dependent and vary by infant age. Result: Our model shows that integrating the lower respiratory tract disease risk based on infant airway diameter and associated airway resistance is critical to appropriately model predicted infant VE. The VE predictions by our models, which preceded maternal RSV prefusion F vaccine efficacy trial primary readouts, closely align with the VE outcomes of these field studies. Conclusion: Our models successfully predicted VE of the RSV maternal vaccines and have potential use in modeling the clinical trial out-comes of other respiratory disease vaccines where maternal antibodies play a role in the protection of newborns.
The Effect of Meloxicam on Inflammatory Response and Oxidative Stress Induced by Klebsiella pneumoniae in Bovine Mammary Epithelial Cells
Authors: Liu Kangjun , Qiu Shangfei , Fang Li , Cui Luying , Dong Junsheng , Guo Long , Meng Xia , Li Jianji , Wang Heng
Published: November 2024

Klebsiella pneumoniae (K. pneumoniae) is a significant pathogen associated with clinical mastitis in cattle. Anti-inflammatory drugs are necessary to alleviate pain and inflammation during clinical mastitis. Among many drugs, meloxicam (MEL) has been widely used in clinical mastitis because of its excellent inhibitory effect on the cyclooxygenase-2 (COX-2) enzyme. However, the effectiveness of MEL on the inflammatory response and oxidative stress induced by K. pneumoniae are unclear. In the present study, primary BMECs were infected with K. pneumoniae in the presence or absence of plasma maintenance concentration of MEL (0.5 and 5 μM). Following 1 or 3 h of combined treatment with K. pneumoniae and MEL, BMECs were gathered to assess the related indicators. The results showed that MEL at plasma maintenance concentrations exerted no influence on the viability of uninfected BMECs and also had no impact on bacterial load in BMECs. At these concentrations, MEL was able to inhibit the mRNA expression of COX-2, Interleukin (IL)-1β, Tumor necrosis factor α (TNF-α), and IL-6 while simultaneously elevating the mRNA levels of IL-8 in K. pneumoniae-infected BMECs. MEL had clear effects on relieving oxidative stress by increasing the activity of superoxide dismutase (SOD) and catalase (CAT) and the level of total antioxidant capacity (T-AOC). The mechanisms by which MEL mitigated the inflammatory response and oxidative stress were partially attributed to inhibition of the nuclear transcription factor-kappa B (NF-κB) signaling pathway and improvement of the activation of the nuclear factor erythroid 2-related factors (Nrf2) signaling pathway. To conclude, the results manifested that MEL at plasma maintenance concentrations protected BMECs from inflammatory and oxidative damage induced by K. pneumoniae.
Dynll1-PI31 Interaction Enhances Proteolysis Through the Proteasome, Representing a Novel Therapeutic Target for INF2-Related FSGS
Authors: Williquett Jillian , Perez-Gill Chandra , Allamargot Chantal , Rooney Faith , Pollak Martin R. , Sun Hua
Published: December 2024

Key Points

The R218Q mutation disrupts sequestration of Dynll1 by inverted formin 2, promotes Dynll1-PI31 interaction, and enhances proteasome-mediated nephrin degradation.

Suppression of proteasome-mediated proteolysis with proteasome inhibitors is a new therapeutic strategy for inverted formin 2-mediated FSGS.

Background

The p.Arg218Gln (R218Q) mutation in the inverted formin 2 (INF2) gene causes podocytopathy prone to FSGS. This mutation disrupts the ability of INF2 to sequester dynein light chain 1 (DYNLL1), thus promoting dynein-mediated mistrafficking of the slit diaphragm protein, nephrin, to proteolytic pathways. Bortezomib, a proteasome inhibitor, stabilizes nephrin in R218Q knockin (KI) podocytes, suggesting a role for the ubiquitin proteasome system (UPS) in dynein-driven pathogenesis. However, the link between dynein and the UPS is unknown. This study tested the hypothesis that INF2 R218Q promotes proteasome-mediated degradation of nephrin through an increased interaction between Dynll1 and the proteasomal inhibitor of 31kD (PI31), a Dynll1 adaptor that potentially couples the UPS with dynein cargoes.

Methods

The essential role of PI31 in UPS-mediated degradation of nephrin, a known dynein cargo, was studied in cultured R218Q KI mouse podocytes by applying genetic or chemical interventions to inhibit the activity of PI31 or of the proteasome. The protective effect of bortezomib in dynein-driven podocytopathy and FSGS was tested in R218Q KI mice challenged with puromycin aminonucleoside, a murine model of FSGS.

Results

The R218Q mutation in INF2 disrupted sequestration of Dynll1 by INF2, allowing Dynll1 to be captured by PI31 and promoting dynein-mediated transport of nephrin to the proteasome. Each of the following manipulations was sufficient to restore nephrin proteostasis in R218Q KI podocytes: knocking down Dynll1 or PI31, inactivating dynein, or inhibiting the activity of the proteasome. In R218Q KI mice challenged with puromycin aminonucleoside, dynein-mediated mistrafficking and depletion of nephrin were correlated with increased Dynll1-PI31 interaction; the resulting podocytopathy and FSGS were ameliorated by bortezomib.

Conclusions

The Dynll1-PI31 interaction facilitates dynein-driven trafficking of nephrin to the proteasome and proteasome-mediated degradation of nephrin in INF2-R218Q-mediated podocytopathy. This mechanism offers new therapeutic strategies for INF2-related FSGS by using pharmacologically available proteasome inhibitors.
Desafios, impactos e potencialidades do uso da inteligência artificial no poder judiciário
Authors: Inouye Cindy Marques , Sardeto Patricia Eliane da Rosa
Published: November 2024

A expansão da inteligência artificial alcançou o Poder Judiciário e é nesta seara que se insere a presente pesquisa, tratando de identificar os desafios, impactos e potencialidades da IA na instituição Poder Judiciário. Buscou-se delimitar os conceitos de inteligência artificial e aprendizagem de máquina, identificar como a IA está sendo usada, bem como seus benefícios, dificuldades e possibilidades. Utilizou-se o método sistêmico proposto por Maturana e Varela, que privilegia a delimitação de um sistema conceitual capaz de explicar o fenômeno observado, para então deduzir seus desdobramentos. Foi possível concluir que não há apenas um conceito para inteligência artificial, mas de forma geral, pode-se afirmar que ela busca replicar a inteligência humana. Um dos seus subcampos é o machine learning, que habilita computadores a aprenderem sozinhos, com a ajuda de um algoritmo. A IA é usada principalmente em atividades repetitivas e para aumentar a celeridade processual. Seus aspectos positivos indicam melhor gestão de recursos humanos, eficácia, agilidade e produtividade. Como adversidades, apontam-se vieses preconceituosos da máquina, incerteza quanto à responsabilização em caso de ofensas produzidas em suas decisões, e a fragmentação de diferentes sistemas utilizados ao redor do país. Os tribunais vêm se adequando à era digital e alguns benefícios já são percebidos, porém novos desafios podem surgir, o que exige um aprofundamento constante nas pesquisas nesta área.
Inclusión laboral de jóvenes, mujeres e inmigrantes en las empresas B uruguayas
Authors: Santiago Silvia Facal
Published: November 2024

Las empresas B o empresas híbridas, han tenido desde el momento en el cual comenzaron a certificarse un gran crecimiento en el mundo y de manera particular en América Latina. Es destacable el fuerte compromiso social, medioambiental y hacia la comunidad que presentan reflejado en diversas iniciativas para la mejora de problemas como el acceso al mercado laboral de los jóvenes, las mujeres e inmigrantes. El objetivo de este trabajo es el de analizar la inclusión laboral de los jóvenes, las mujeres e inmigrantes en las empresas B uruguayas, tres actores sociales vulnerables de la sociedad. 
Para encuadrar la problemática tratada en esta investigación hemos recurrido a autores referentes en la materia como Ryan Honeyman, Haigh y Hoffman entre otros.
El presente trabajo tiene un alcance exploratorio y descriptivo acompañado de un abordaje metodológico mixto en donde predomina del enfoque cuantitativo sobre el cualitativo. Las técnicas metodológicas utilizadas son las fuentes secundarias estadísticas, la encuesta, a través de la cual se ha medido el impacto de las empresas B en la inclusión de jóvenes, mujeres e inmigrantes en el mercado laboral, las entrevistas en profundidad a expertos y el análisis de contenido.
El mega puerto de Chancay: una herramienta clave para el desarrollo sostenible en el Perú
Authors: Sandoval Jorge Lescano , Sena Lucía Emperatriz Valdéz , Lobo Manuel Rimarachin , Cabrera Jonathan Novoa , García José Tomás Mendoza , Pedraza Karina Inés Hinojosa , Cristóbal Carmen Rocío Chávez
Published: November 2024

El presente trabajo aclara la falsa percepción de la ciudadanía respecto al Foro APEC 2024 y la inauguración del Megapuerto de Chancay, este último promovido por el Gobierno del Perú. Asimismo, expone aspectos relacionados con la sostenibilidad del Megapuerto y su competitividad. A fin de evitar su colapso, se presentan causas a evitar y la gestión portuaria a seguir basada en los puertos mejor posicionados en el ranking mundial 2024. Se comentan aspectos sobre la conveniencia o no de contar con una Zona Económica Especial – ZEE. Se señalan los beneficios y ventajas de implementar un Sistema de Gestión para los Objetivos de Desarrollo Sostenible de las Naciones Unidas, entre otros.
Маркеры неблагоприятного прогноза у пациентов с миелодиспластическим синдромом: способ прогнозирования исхода заболевания
Authors: А.С. Трубкина , И.А. Искров , И.Ю. Лендина , В.В. Смольникова , Т.В. Лебедева
Published: December 2024

Терапия выбирается в зависимости от риска, потребности в переливании компонентов крови, процента бластов в костном мозге и цитогенетического профиля. В группах низкого риска целью лечения является снижение потребности в заместительной терапии и профилактика трансформации в более высокий риск или острый миелоидный лейкоз. В группах более высокого риска цель – продлить выживание. В настоящее время нет утвержденных критериев выбора терапии пациентов с миелодиспластическим синдромом (МДС) на основе используемых классификаций и прогностических шкал, схем лечения при прогрессии МДС или его рефрактерных форм. Терапия МДС является сложной проблемой вследствие неблагоприятных демографических характеристик основной группы пациентов (средний возраст 65–70 лет), имеющих большое количество сопутствующих заболеваний и низкую толерантность к возможному проведению интенсивной терапии. Необходимо также отметить, что при трансформации в ОМЛ такие пациенты демонстрируют более низкий ответ на стандартную терапию, чем пациенты de novo ОМЛ [1]. В настоящее время IPSS и IPSS-R остаются наиболее часто используемыми прогностическими моделями в клинической практике, но при их применении на практике также выявлены некоторые недостатки, так как шкалы IPSS и IPSS-R были разработаны для пациентов с впервые выявленным МДС, которые не получали специфической терапии [2, 3].

Therapy is selected based on risk, need for transfusion of blood components, percentage of blasts in the bone marrow and cytogenetic profile. In low-risk groups, the goal of treatment is to reduce the need for replacement therapy and prevent transformation to higher risk or acute myeloid leukemia. In higher risk groups, the goal is to prolong survival. Currently, there are no approved criteria for selecting therapy for patients with myelodysplastic syndrome (hereinafter referred to as MDS) based on the classifications and prognostic scales used, treatment regimens for progression of MDS or its refractory forms. Treatment of MDS is a complex problem due to the unfavorable demographic characteristics of the main group of patients (average age 65–70 years), who have a large number of concomitant diseases and low tolerance to possible intensive therapy. It should also be noted that when transformed into AML, such patients demonstrate a lower response to standard therapy than patients with de novo AML [1]. Currently, the IPSS and IPSS-R remain the most commonly used prognostic models in clinical practice, but some shortcomings have also been identified in their use in practice, since the IPSS and IPSS-R scales were developed for patients with newly diagnosed MDS who did not receive specific treatment. therapy [2, 3].
Показатели ЭЭГ и РЭГ у рабочих с различной степенью профессиональной тугоухости
Authors: М.А. Бекмурадов , М.Т. Насретдинова , Ж.А. Хатамов , Э.И. Рустамова
Published: November 2024

Введение. Слуховая зона коры головного мозга первой реагирует на шумовое воздействие, давая толчок к последующим изменениям в других звеньях звукового анализатора. Клинические и экспериментальные наблюдения указывают также на тесную взаимосвязь нарушений церебральной гемодинамики и биоэлектрической активности головного мозга при различных заболеваниях. Цель. Изучить показатели биоэлектрической активности головного мозга и церебральной гемодинамики по данным ЭЭГ и РЭГ у лиц, подвергавшихся длительному воздействию производственного шума. Материалы и методы. Обследовано 102 человека в возрасте от 23 до 55 лет, работающих в условиях производственного шума. Для исследования состояния церебральной гемодинамики использовали биполярную реоэнцефалографию. Проведена статистическая обработка результатов исследований. Электроэнцефалограмму записывали в звукопоглощающей камере в положении испытуемого сидя с помощью 14-канального электроэнцефалографа. Результаты. Структура гемодинамики у рабочих «шумовых» профессий была неоднородной. По мере ухудшения слуховой функции изменялись и показатели гемодинамики. О повышении сосудистого тонуса свидетельствовали и показатели дикротического индекса. У работающих в условиях шума даже с нормальным слухом в корковых структурах головного мозга возникают стойкие очаги возбуждения. Заключение. Снижение амплитуды α-ритма в височных и затылочных областях головного мозга по мере ухудшения слуха у рабочих подтверждает наличие изменений в корковых структурах мозга.

Introduction. The auditory zone of the cerebral cortex is the first to respond to noise exposure, triggering subsequent changes in other parts of the sound analyzer. Clinical and experimental observations also indicate a close correlation between cerebral hemodynamic disorders and bioelectrical activity of the brain in various diseases. Purpose. To study brain bioelectrical activity and cerebral hemodynamic parameters according to EEG and REG data in individuals exposed to prolonged industrial noise. Materials and methods. A total of 102 people aged 23 to 55 years working in industrial noise conditions were examined. Bipolar rheoencephalography was used to analyze cerebral hemodynamics. Statistical processing of the research results was carried out. Electroencephalograms were recorded in a sound-absorbing chamber in the sitting position using a 14-channel electroencephalograph. Results. Hemodynamic structure in workers of "noisy" occupations was heterogeneous. As the auditory function deteriorated, hemodynamic parameters changed. Increasing vascular tone was also evidenced by the dicrotic index. In noise workers, even in those with normal hearing, persistent foci of arousal appear in the cortical structures of the brain. Conclusion. Decreasing in α-rhythm amplitude in the temporal and occipital regions of the brain along with hearing deterioration in workers confirms alterations in the cortical structures of the brain.
Современные представления об атипичных мастоидитах: обзор литературы
Authors: И.Д. Мухмадов , В.П. Шпотин , В.А. Сайдулаев , Ш.М. Алиев , А.К. Нуралиева
Published: November 2024

Атипичный мастоидит характеризуется скудной со стороны височной кости клинической картиной, являющейся показанием к экстренному оперативному вмешательству. Относительно редкая встречаемость атипичных мастоидитов обуславливает их недостаточную освещенность в медицинской литературе. Проведен поиск и анализ современных научных публикаций из общедоступных информационных ресурсов, включая обзорные статьи, оригинальные исследования, монографии, наблюдения клинических случаев, учебные пособия, материалы отечественных и зарубежных авторов, представленные на международных конференциях. Описаны анатомические и топографические особенности височной кости, способствующие возникновению атипичного мастоидита, клинические проявления и диагностические критерии его различных форм. Отмечено, что отсутствие достоверных методов выявления деструкции височной кости на ранних этапах воспаления является причиной несвоевременного начала адекватного лечения, что нередко ведет к интракраниальным осложнениям. Поиск и разработка способов ранней диагностики остеодеструкции остаются актуальной проблемой, решение которой позволит оптимизировать лечение различных форм острого мастоидита.

Atypical mastoiditis is characterized by a scanty clinical picture in the temporal bone, which is indicative for emergency surgery. A relatively rare occurrence of atypical mastoiditis is the reason for its insufficient coverage in the medical literature. A search and analysis of modern scientific publications from publicly available information resources were performed, including surveys, original studies, monographs, clinical case reports, textbooks, Russian and foreign authors’ materials presented at international conferences. Anatomical and topographical features of the temporal bone contributing to atypical mastoiditis, as well as clinical manifestations and diagnostic criteria for its various forms are described. It is noted that the lack of reliable methods for temporal bone destruction detection at early stages of inflammation is the reason for untimely starting of adequate treatment, often resulting in intracranial complications. Searching for and elaborating methods for early diagnosis of osteodestruction remain an urgent challenge, whose achievement will allows optimizing treatments of various forms of acute mastoiditis.
Effects of Thin Cell Layer Technique and Nutrient Media Contents of Regeneration and Browning Characteristics of the Laurus nobilis L. Explants
Authors: Toska Büşra , Güngör Halide Hande , Gürel Aynur
Published: November 2024

The aim of this study is in order to investigate the effects of explant source, explant type and MS media composition containing different concentrations of sucrose, activated carbon and Coconut milk for regeneration and browning of Laurus nobilis L. using thin cell layer (TCL) culture system. A higher rate of callus (57.15%) and shoot (2%) regeneration and a lower rate of blackening were determined in transversely cut stem TCL explants compared to leaf explants. While 1.33% callus regeneration was achieved in leaf explants; shoot regeneration could not be achieved. While more callus regeneration (35.17%) was found in explants taken from the field, more shoot regeneration (1.5%) and lower rate of browning were obtained in explants taken from in vitro. In the sugar trials, the highest callus regeneration (40.83%) was defined in MS medium containing 30 g/L sucrose supplemented with 1 mg/L BAP, and the highest shoot regeneration (2.5%) was determined in MS medium containing 45 g/L and 60 g/L sucrose supplemented with 1 mg/L BAP. When explant type, explant source and nutrient media composition are considered together; the highest callus regeneration (100%) was obtained in field-sourced stem TCL explants cultured in medium containing 25 mL/L coconut milk and 1 mg/L BAP. The highest shoot regeneration (6.6%) was determined in in vitro stem TCL explants cultured in MS media containing 30, 45, 60 g/L sucrose and 1 mg/L BAP. The lowest percentage of browning (50%) was obtained from in vitro stem TCL explants cultured in MS medium containing 2 g/L activated carbon and 1 mg/L BAP.
Nuevos registros y listado de abejas sin aguijón (Hymenoptera: Apidae: Meliponini) del paisaje cafetero del corredor Andino-Amazónico (Huila, Colombia)
Authors: Sardi-Saavedra Antonella , Acuña-Figueroa Sophia
Published: November 2024

Las abejas sin aguijón componen uno de los grupos de insectos más importantes para la polinización de plantas silvestres y cultivadas. Recientemente han aumentado los esfuerzos para llenar los vacíos de información respecto a la composición de especies de abejas en algunas regiones de Colombia. No obstante, el conocimiento de las abejas silvestres sin aguijón (Hymenoptera: Apidae: Meliponini) del departamento del Huila en Colombia es incipiente, particularmente en el paisaje cafetero del Corredor de Transición Andino-Amazónico (CTAA). El objetivo de este estudio fue elaborar y proporcionar el listado de especies y los nuevos registros de abejas silvestres sin aguijón
para el paisaje cafetero del Corredor de Transición Andino-Amazónico del departamento del Huila,
Colombia. Entre noviembre de 2023 y junio de 2024 se recolectaron abejas con red entomológica y
aspirador bucal en 18 áreas naturales (bordes de bosque ripario, bordes de cafetal, rastrojo, cercos
vivos o franjas de vegetación arbóreas y herbáceas) en el paisaje cafetero del CTAA. Se reportan en
total 17 especies de abejas sin aguijón para el CTAA del Huila, de estas siete son nuevos registros
de abejas, cuatro para el CTAA del Huila: Frieseomelitta paupera Provancher, Geotrigona subgrisea
Cockerell, Nannotrigona tristella Cockerell y Trigona fuscipennis Friese y tres son nuevos registros
para el departamento del Huila: Nannotrigona melanocera Schwarz, Scaptotrigona magdalenae Engel y
Tetragona perangulata Cockerell. En conclusión, estos hallazgos permiten tener un mejor conocimiento
de las abejas sin aguijón y su distribución en el CTAA el Huila, lo cual es importante pues aporta
información para la conservación de estos polinizadores nativos en la región.
Vinsensius de Paul “Seorang Kanonis” Catatan Yuridis-Kanonik seputar Pendirian Kongregasi MisiBagian I: Beberapa Akta Awal (1625-1627)
Authors: Galed Daniel Ortega
Published: November 2024

Banyak yang tidak mengetahui bahwa Vincent Depaul adalah seorang ahli hukum kanonik. Lebih sering daripada tidak, orang hanya berfokus pada karya-karya amalnya. Pendirian Kongregasi Misi pada abad ke-17 sebenarnya merupakan sebuah “terobosan” dalam hukum kanon. Vinsensius, sebagai seorang imam yang lahir setelah Konsili Trente, mencoba menjawab tantangan reformasi internal di dalam Gereja dengan mendirikan sebuah kelompok yang terdiri dari para biarawan dan biarawati yang hidup bersama dalam sebuah komunitas religius dengan tetap mempertahankan karakter sekulernya. Ini adalah sesuatu yang sangat tidak biasa pada waktu itu dalam perundang-undangan gerejawi. Gagasan Vinsensius memang melampaui tradisi yuridis pada waktu itu, tetapi hanya karena kebutuhan Gereja: ia melihat dan menyaksikan sendiri kemiskinan rohani di desa-desa karena buruknya kualitas para imam dan ketidaksediaan mereka untuk melayani gerejawi tanpa bayaran. Oleh karena itu, tampaknya selalu ada hubungan antara spiritualitas dan aspek yuridis pada periode awal pendirian Kongregasi Misi. Secara historis-kanonik, ide-ide Vinsensius dapat ditemukan baik secara langsung maupun tidak langsung dalam berbagai tindakan awal yang berkaitan dengan pendirian kongregasi. Studi ini berusaha untuk menunjukkan karakter yuridis yang paling mendasar dari masa-masa awal Kongregasi Misi secara langsung dari niat pendirinya, Vinsensius Depaul.
Membentuk Pemimpin Gereja Masa Depan: Mengadopsi Kebijaksanaan Salomon dalam Pembinaan Imam Vinsensian
Authors: Da Sales Yohanes Bunni , Jimiardi Thymotius , Adiman Gabriel Geri Goa
Published: November 2024

Penelitian ini menjawab pertanyaan penting: Bagaimana kita dapat membentuk pemimpin gereja masa depan yang mampu menghadapi tantangan zaman? Dengan mengintegrasikan kebijaksanaan Salomo dalam model pembinaan imam Vinsensian, penelitian ini menawarkan jawaban yang inovatif. Melalui metode penelitian kajian literatur biblikal dan berdasarkan kajian literatur spiritualitas vinsensian, penelitian ini menunjukkan bahwa para imam yang mengikuti program pembinaan ini mengalami transformasi signifikan dalam zaman sekarang yang semakin mengalami banyak perkembangan dan perubahan di berbagai bidang. Temuan ini mengindikasikan bahwa kebijaksanaan Salomon dapat menjadi kompas yang memandu para imam dalam menjalankan tugas pelayanan mereka dengan penuh integritas dan kasih. Dengan mengkolaborasikannya dengan semangat dan spiritualitas Vinsensian. Dengan tujuan untuk masuk dalam pelayanan Gereja, seorang calon imam meski ditempa dengan berbagai media yang membuatnya berkembang. Terutama perkembangan dalam semangat dan spiritualitas hidup dan dirinya. Maka dengan mengintegrasikan makna kebijaksanaan dan keutamaan vinsensian seorang calon pemimpin Gereja dibawa pada karakter pemimpin yang memiliki iman, persaudaran dan bela rasa.
ANALISI STABILITAS KAPAL RISET POLBENG DI PERAIRAN SEA-STATE 3
Authors: Purwoko Muhammad Sidik
Published: November 2024

Kapal Riset Polbeng merupakan kapal yang akan di bangun oleh Politeknik Negeri Bengkalis (Polbeng) bekerjasama dengan CV. Fatih bahari Enginering. Kapal ini berbahan Plastic High Density Polyethylene (HDPE), dengan ukuran utama kapal: Panjang LOA adalah 9 meter, Lebar B adalah  2.2 meter, Tinggi H adalah 1.2 meter, dan menggunakan mesin outboat 85 HP. Studi kenyaman kapal ini dilakukan untuk melihat performa kapal terhadap peralatan dan manusia dalam menunjang kegiatan Riset yang dilakukan oleh pihak Polbeng. Stabilitas adalah hal wajib yang harus terpenuhi karena untuk menjamin keselamatan dan kenyamanan. Pada penelitian ini di kondisikan pada 2 loadcase kapal yaitu pada kondisi kapal penuh dan kondisi kapal kosong kemudian mengacu pada regulasi IMO. Analisa perhitungan stabilitas kapal dengan kondisi lightship, serta fulload. Hasil analisa pada kondisi lightship dengan 8 penumpang diperoleh nilai lengan penegak GZ max sebesar 0,82 meter pada kemiringan 500, (kualifikassi IMO tidak boleh kurang atau sama dengan 25º (deg). Sedangkan buat periode oleng tertingi pada kondisi muatan fullload dengan respon saat 0,482 second, memenuhi kriteria IMO Code A.749 (18) Ch 3 - design criteria applicable to all ship.
Komparasi Berat Konstruksi 300 Feet Barge dengan Deck Load 5 T/m2 dan 8 T/m2
Authors: Mustikawati Diana Langgeng
Published: November 2024

Perkembangan teknologi kapal mulai menunjukan kearah lebih baik, kapal sebagai media utama transportasi di laut merupakan ladang bisnis yang cukup menjanjikan di industri pembangunan kapal di Indonesia, faktor-faktor yang mempengaruhi perkembangan kondisi kapal sangat diperhatikan, terutama hal yang menyangkut efisiensi dan efektifitas produksi kapal. Berat baja kapal merupakan hal utama yang menjadi pertimbangan bagi owner maupun pihak galangan mengenai pembangunan kapal, karena dengan bertambah besarnya berat yang dimiliki kapal akan mengurangi jumlah muatan yang dapat diangkut oleh kapal tersebut. Tujuan penelitian ini yaitu untuk mengetahui komparasi berat konstruksi 300 feet barge dengan deck load 5 T/   dan 8 T/  . Jenis penelitian yang digunakan peneliti yaitu jenis penelitian mengunakan pendekatan metode kuantitatif. Penelitian ini menggunakan dua variabel yaitu variabel bebas dan variabel terikat. Variabel bebasnya adalah komparasi berat konstruksi. Total keseluruhan perhitungan berat konstruksi 300 Feet barge deck load 5 T/   adalah 967282,1 kg/ 967,2821 ton; sedangkan total keseluruhan perhitungan berat konstruksi barge 300 feet deck load 8 T/   adalah 1098662 kg/ 1098,662 ton.
INFLECTION OF NOMINAL PARTS OF SPEECH IN THE PRIVILEGES TO THE KYIV CITY MAGISTRATE
Authors: Tytarenko V. , Yashchuk L.
Published: November 2024

The article analyzes the morphological features of the Privileges of the Kyiv Magistrate. The text of the record is kept in the Central State Archives (f. 62, in. 1, case 1). These documents are a copy of the 18th century. certificates issued to confirm the Magdeburg law of Kyiv for the years 1544–1659, taken from the private collection of Kozma Krychevets.
The study reveals the use of old and new endings in the paradigm of the noun, adjective, numeral, and pronoun in individual cases, which reflects the stage of formation of word change in the Ukrainian language. Adjective word change is characterized by the functioning of mainly compound adjectives and singular nouns. Among pronominal declensions, we notice the use of compound and non-compound forms, clipped forms are used sporadically under the influence of the Polish language. The inflection -ago of Church Slavonic origin is common. Fluctuations in the writing of forms are often reflected both in the same word and in different ones, parallelism is often found side by side. The outlined variability is caused by the lack of normalization of orthographic features, the procedural nature of language phenomena in the analyzed period, the preservation of traditions and the influence of the living language element, the interaction of the phonetic and morphological systems of the Church Slavonic, Polish and Ukrainian languages.
Individual word forms found in the analyzed text functioned under the influence of a foreign language, in particular, some were strengthened under the influence of the Polish language, while others were borrowed from it. In some places, Old Slavic elements can be traced in word change (inflection -ago in adjectives, participles).
Therefore, the analysis of the nominal parts of speech used in the letters of the Kyiv magistrate shows that in the system of declension of this category of words in the 16–17 centuries new (vernacular) forms were established, which later became the literary norm, archaic elements that were a tribute to the book tradition are also attested in a small amount. Along with such variants, foreign language influences are clearly marked – Polish and Church Slavonic languages. It is most likely that Church Slavonic forms were already included in the copy/translation of the 18th century, since such influences did not appear in records of the business style of previous centuries.
VOCABULARY FOR DESIGNATING VISUAL SENSATIONS IN THE REPRESENTATION OF YURI IZDRIK: LINGUISTIC SPECIFICITY, MORPHOLOGICAL EXPRESSION (ON THE MATERIAL OF THE "LOVE CALENDAR")
Authors: Yarynovska K.
Published: November 2024

The article analyzes the specifics of the functioning of the vocabulary to denote visual sensations on the material of one of the most famous modernist poets. The article determines that such vocabulary reflects one of the primary ways of experiencing the external world: colors, sounds, tastes, visual elements, etc. The object of our research is the visual vocabulary in Yuriy Izdrik's collection "Calendar of Love", taking into account its linguistic specificity and morphological expression. In linguistics, there is a substantial amount of research devoted to the analysis of the perceptual picture of the world, however, research in the field of visual vocabulary is rather small. The article describes the theoretical-methodological bases of identifying sensorisms, types of perceptual vocabulary. The study of perceptual vocabulary is quite relevant in our time, since the study of the work of postmodernist poets has become one of the objects of study only in the last few years. On the material of the "Calendar of Love" collection, examples of the use of visual vocabulary were singled out and each of the examples of use was analyzed separately, taking into account the morphological expression, linguistic specificity of use, interpretation by Yuriy Izdryk. In the author's poems, on the basis of which the research was carried out, visual sensorisms are one of the most connected modes, in particular, a significant number of visual sensorisms were highlighted, when the author uses the sign of olfactory and visual perception within the same stanza, as sensations that are quite connected closely. The vast majority of lexemes – visual percepts are characterized by the use of typical lexemes in atypical or uncharacteristic meanings for them. Another feature is that the author emphasizes the lack of visual perception, in particular depicts complete blindness.
HISTORICAL, FOLKLORIC AND ETHNOGRAPHIC FUNDAMENTALS OF FRANKO’S SHORT STORY "DOVBANYUK"
Authors: Pylypchuk S.
Published: November 2024

The article analyzes the historical background and the folkloric and ethnographic context of Ivan Franko's short story "Dovbanyuk." The work, which was published in 1886 in the journal "Zorya", served as a literary extension to the discussion on the pressing issue of Ukrainian-Polish relations. Once again, the writer put forward an effective formula for resolving the problem, relying on the principles of mutual respect and the search for consensus. The story highlights one of the vivid episodes in the history of Halychyna, related to the events of the turbulent year of 1863, when another unsuccessful Polish uprising took place. Through the lens of this literary work and using the realias of one Boyko village, the author attempts to portray the true state of affairs on the eve of and during the outbreak of the insurrection. The central figure in the story is the impoverished nobleman Yuriy Horodysky (known in the village by the nickname "Dovbanyuk"), who is a typical representative of the so-called "chodaczkowa szlachta" – a still significant stratum of society in the mid-19th century. Franko vividly illustrates this character, paying attention to his appearance, behavior, and psychology. Through the often tense relationships Dovbanyuk has with his fellow villagers, the author underscores the complex interactions between the nobility (even those who had fallen into extreme poverty) and the peasants. This conflict reaches its peak during the Polish armed uprising. When Horodysky decides to join the insurgents, it causes irritation and ridicule among the villagers, who, remembering the past abuses of the nobility, are in no way eager to see the return of "Old Poland". In the final part of the story, Dovbanyuk’s epiphany comes to the forefront, as through his own experience with the uprising, he finally realizes the impossibility of restoring the old order. Franko skillfully enriches the story with historical facts and integrates folkloric and ethnographic elements into the fabric of the text, giving it a unique coloring.
Diabetic Foot Gymnastics improves foot sensitivity in patients with Type 2 Diabetes Milletus
Authors: Wijayanti Agnes , Yunitrie Erwinda
Published: November 2024

Diabetes mellitus merupakan jenis penyakit tidak menular yang apabila dibiarkan dapat menyebabkan penyakit salah satunya adalah neuropati sensori akibatnya menimbulkan komplikasi. Penanganan yang perlu dilakukan adalah dengan cara melakukan latihan jasmani berupa senam kaki diabetik sebagai salah satu upaya untuk meningkatkan sensitivitas kaki pada pasien dengan diabetes mellitus, tujuan penelitian yaitu mengetahui pengaruh senam kaki diabetik terhadap tingkat sensitivitas pada penderita Diabetes Mellitus, metode penelitian menggunakan studi kasus deskriptif, dimana dalam studi kasus ini akan menjelaskan tentang kasus yang dialami oleh 2 pasien diabetes mellitus dengan aplikasi senam kaki diabetik, Instrument yang digunakan adalah Monofilament 10 g dan lembar observasi senam kaki. Hasil penelitian adanya pengaruh terhadap peningkatan sensitivitas kaki dari kedua responden sebelum dilakukan senam kaki dalam kategori risiko tinggi terjadi neuropati dalam waktu 4 tahun kedepan. Setelah dilakukan senam dalam kategori risiko rendah terjadi neuropati dalam waktu 4 tahun kedepan. Kesimpulan Setelah dilakukan senam kaki 3x dalam 1 minggu selama 30 menit menunjukkan adanya peningkatan sensitivitas kaki.
Hubungan Usia dan Pekerjaan dengan Kejadian Hipertensi di Desa Sungaibuntu Tahun 2023
Authors: Nursolihah Iha , Sembiring Dian Agnesa , Aulia Istiana Faizah , Ramadhanti Ikrimah Fitri , Putri Salwa Adelia , Indirajati Almira Shidqi
Published: November 2024

Introduction: The World Health Organization (WHO) states that one in three people is diagnosed with hypertension, and only 36.8% of them are undergoing treatment. In Indonesia, the age group with the highest hypertension is the elderly. Research Objective: To determine the relationship between age and occupation with the incidence of hypertension in Sungaibuntu. Research Method: Quantitative analytical research with a cross sectional research design, using primary data through questionnaires and blood pressure measurements on research respondents, namely residents of Sungaibuntu. Research Results: There is a significant relationship between age and systolic blood pressure (p=0.0001), and there is a significant relationship between age and diastolic blood pressure (p=0.018). Meanwhile, for the work variable, there was no relationship between work and systolic blood pressure (p=0.335), and there was no significant relationship between work and diastolic blood pressure (p=0.223). Conclusion: There is a positive correlation between age and systolic blood pressure and age and diastolic blood pressure, meaning that the higher the age, the higher the incidence of hypertension. Meanwhile, work was not related to the incidence of hypertension in respondents in Sungaibuntu.
KORELASI PENDAPATAN KELUARGA DAN TINGKAT PENDIDIKAN DENGAN KEJADIAN STUNTING
Authors: Handayani Saadah
Published: November 2024

Latar belakang: Menurut referensi WHO tahun 2005, stunting (pendek) adalah salah satu jenis gizi kurang yang ditandai dengan tinggi badan menurut umur diukur dengan standar deviasi.  Indikator TB/U menunjukkan masalah gizi jangka panjang yang disebabkan oleh kondisi yang berlangsung lama, seperti kemiskinan, perilaku hidup yang tidak sehat, dan pola asuh dan pemberian makan yang buruk sejak kelahiran, yang menyebabkan anak menjadi pendek. Determinan terdiri dari faktor dasar, seperti pendidikan dan ekonomi ibu, dan faktor intermediet, seperti jumlah anggota keluarga, tinggi badan ibu, usia, dan jumlah anak ibu juga menjadi faktor penyebab stunting.  Tujuan : Untuk mengetahui hubungan pendapatan keluarga dan tingkat pendidikan  dengan kejadian stunting pada balita usia 24-60 bulan Metode : Penelitian ini dilakukan secara observasional menggunakan desain case control study. Pengambilan data dilaksanakan pada bulan Desember 2023. Dengan jumlah populasi balita stunting 323 balita usia 0-60 bulan, jumlah sampel 64 responden balita stunting dan tidak stunting usia 24-60 bulan di Puskesmas Paduraksa Kabupaten pemalang , dengan tehnik purposive sampling. Analisis univariat dengan distribusi frekuensi tentang pendapatan keluarga dan tingkat pendidikan, analisa bivariat menggunakan uji chi square.  Hasil : pendapatan keluarga pada balita stunting sebagian besar <UMR sebesar 26 responden (81,3%) dan pendapatan keluarga pada balita yang tidak stunting sebagian besar ?UMR sebesar 22 responden (66,8%). Hasil pada tingkat pendidikan didapatkan sebagian besar tingkat pendidikan ibu pada balita stunting 22 responden (68,74%) berpendidikan dasar dan pendidikan ibu pada balita tidak stunting sebagian besar tingkat pendidikan atas 20 responden (62,50%) . Ada hubungan pendapatan keluarga dengan p value 0,028 dan tidak ada korelasi tingkat pendidikan dengan kejadian stunting dengan p value 0,660.Kata kunci : Pendapatan keluarga, Tingkat Pendidikan, Stunting
PENGARUH PEMBERIAN PEPAYA (CARICA PAPAYA L) TERHADAP PENINGKATAN VOLUME PRODUKSI ASI PADA IBU MENYUSUI DI DESA NGEMBAK KECAMATAN PURWODADI
Authors: Sugiarti Wiwit , Yuwanti Yuwanti , Ekasari Wahyu Utami
Published: November 2024

Latar belakang:  Masalah yang sering terjadi dalam proses menyusui salah satunya adalah ketidaklancaran produksi ASI, hal tersebut membuat kebanyakan ibu memilih untuk pemberian susu formula pada bayinya. Untuk mengatasi masalah tersebut maka pepaya dapat digunakan sebagai ASI booster karena memiliki kandungan laktagogum yang dapat mempengaruhi produksi ASI. WHO dan UNICEF mencatata bahwa cakupan ASI eksklusif pada tahun 2019 mencakup 41%. Sedangkan di Desa Ngembak sendiri untuk cakupan ASI eksklusif juga masih tergolong rendah yaitu 66,67% pada tahun 2023. Tujuan dilakukannya penelitian ini adalah untuk mengetahui bagaimana pengaruh pemberian pepaya terhadap peningkatan volume produksi ASI pada ibu menyusui di Desa Ngembak Kecamatan Purwodadi.Metode:  Penelitian ini merupakan penelitian kuantitatif menggunakan desain pre eksperimen dengan rancangan one grup pre test post test desaign. Dengan teknik pengambilan sampel yaitu purposive sampling. Sampel dalam penelitian adalah 35 ibu menyusui dan uji analisis yang digunakan adalah Uji Independent T-test.Hasil:  Hasil penelitian menunjukkan bahwa ada pengaruh pemberian  pepaya terhadap peningkatan volume produksi ASI pada ibu menyusui dengan nilai p-value 0.000.Kesimpulan:  Berdasarkan hasil penelitian tersebut maka dapat ditarik kesimpulan bahwa terdapat pengaruh pemberian pepaya terhadap peningkatan volume produksi ASI pada ibu menyusui di Desa Ngembak Kecamatan Purwodadi. Kata kunci : Pepaya, ASI eksklusif, Ibu Menyusui, Volume ASI
Efek Penambahan Ekstrak Daun Tagalolo (Ficus Septica Burm. F) terhadap Kadar Histamin dan Total Bakteri Ikan Cakalang (Katsuwonus pelamis L)
Authors: Kaunsui Marledi , Masinambou Charles , Saragih Ella Dertina , Harikedua Silvana D , Pandey Engel , Wonggo Djuhria , Montolalu Lita , Makapedua Daisy Monica
Published: December 2024

Histamine is one of the important parameters in determining the quality of fish quality, especially in fishery products that will be exported. This study aims to determine the effect of adding tagalolo leaf water extract on histamine levels and total plate counts in fresh skipjack (Katsuwonus pelamis L). The results showed that tagalolo leaves have the potential to slow down the rate of histamine and bacterial development in fish
Keyword: skipjack, histamine, tagalolo leaves, total plate count
 
Histamin merupakan salah satu parameter penting dalam penentuan kualitas mutu ikan terutama pada produk perikanan yang akan diekspor. Penelitian ini bertujuan untuk mengetahui efek penambahan ekstrak air daun tagalolo terhadap kadar histamin dan angka lempeng total pada ikan cakalang (Katsuwonus pelamis L) segar. Hasil penelitian menunjukkan bahwa daun tagalolo memiliki potensi untuk dapat memperlambat laju perkembangan histamin dan bakteri pada ikan.
Kata kunci: ikan, histamine, daun tagalolo, angka lempeng total
Pemberdayaan Kewirausahaan Kelompok Wanita Tani (KWT) dalam Pengembangan Inovasi Produk Makanan (Desa Cipedes, Kecamatan Ciniru, Kabupaten Kuningan)
Authors: Setiawan Iyan , Luviantika Irsa , Dandi  , H Siska Aulia
Published: November 2024

This study aims to implement a women farmer empowerment program in Cipedes Village through the innovation of traditional sagon food processing to enhance entrepreneurial skills. The methods used in this study include training, mentoring, and evaluation of women's farmer groups (KWT) in producing and marketing sagon more innovatively. The results show that innovations in sagon processing, including taste, shape, and packaging, have successfully increased market interest in this product. Furthermore, providing training and guidance on using digital technology for marketing has improved the entrepreneurial knowledge and skills of KWT members. This program has not only contributed to increasing household income but also strengthened the role of women farmers in local economic development. Therefore, empowering women farmers through the innovation of traditional food processing like sagon has great potential to be further developed as a model for economic empowerment in rural areas.