bluuebunny/crossref_metadata_2025 huggingface dataset:
FOXD3 Suppresses the Proliferation of CRC Bone Metastatic Cells via the
Ras/Raf/MEK/ERK Signaling Pathway
Authors: Wang Kangwei , Chu Yan , Zhang Hongqiang , Qu Xinglong , Wang Bing , Han Yu
Published: May 2023

Background:

The improvements in the treatment of colorectal cancer (CRC) and prolongation
of survival time have improved the incidence of bone metastasis. Forkhead box D3
(FOXD3) is involved in the development of CRC. However, the role and mechanism of FOXD3 in
CRC bone metastases development are unknown.

Objective:

Using the combined bioinformatics and cytology experimental analyses, this study
aimed to explore the mechanistic role of FOXD3 in the bone metastasis of colon cancer, thereby aiding
in the treatment of colon cancer bone metastasis and identification of drug-targeting markers.

Methods:

First, the changes in the expression levels of the FOXD3 gene and differentially expressed
genes (DEGs) between the colon cancer samples and colon cancer metastases were obtained
from The Cancer Genome Atlas (TCGA) database. Then, the correlations of the FOXD3
gene with the DEGs were identified. Next, the effects of the FOXD3 on the proliferation and invasion
abilities of colon cancer bone metastatic cells were identified using Cell Counting Kit-8
(CCK8) and Transwell cell migration assays, respectively. In addition, Western blot analysis was
used to identify the expression levels of the proteins related to the EGFR/Ras/Raf/MEK/ERK
(EGFR/ERK) signaling pathway and epithelial-to-mesenchymal transition (EMT).

Results:

FOXD3 was downregulated in colon cancer and could interact with multiple DEGs in colon
cancer bone metastases. FOXD3 gene knockdown could increase the proliferation of human
colon cancer bone metastatic cells and their invasive ability. FOXD3 gene knockdown could activate
the expression of EGFR/ERK signaling pathway-related proteins and inhibit/promote the expression
of EMT-related proteins, which in turn promoted the proliferation and metastasis of LoVo
cells from colon cancer bone metastases.

Conclusion:

Overall, this study demonstrated that the downregulation of the FOXD3 gene might
promote the proliferation of colon cancer bone metastatic cell lines through the EGFR/ERK pathway
and promote their migration through EMT, thereby serving as a promising therapeutic target.
Anti-tumoral Titanium(IV) Complexes Stabilized with Phenolato Ligands and Structure-Activity Relationship
Authors: Zhao Tiankun , Wang Peng , Zhang Xupeng , Liu Nan , Zhao Wenzhuo , Zhang Yong , Yuan Pengpeng , Li Shanjia , Yang Mingjun , Yang Zhongduo , Huhn Thomas
Published: May 2023

Titanocene dichloride and budotitane have opened a new chapter in medicinal chemistry of titanium(IV) complexes being novel non-platinum antitumor metallic agents. Numerous efforts have led to the discovery of the diamino bis-phenolato titanium(IV) complexes. Among which, the [ONNO] and [ONON] type ligands namely Salan, Salen and Salalen coordinated titanium(IV) alkox-yl complexes have demonstrated significantly enhanced aqueous stability, their in vitro and in vivo antitumor efficacy, mechanism of action, structure-activity relationships and combined tumor thera-py have been intensively investigated. Replacement of the labile alkoxyls with a second chelator re-sulted in structural rigid titanium(IV) complexes, which showed exceedingly good aqueous stability and potent antitumor activity both in vitro and in vivo. The unique ligand system successfully al-lowed the access of isotopic [45Ti]Titanium(IV) complexes, post-synthetic modification, facile syn-thetic protocols and antitumor congeneric zirconium(IV) and hafnium(IV) complexes. This review presents recent research progress in the field of antitumor group 4 metal complexes stabilized with phenolato ligands; especially their structure-activity relationships are summarized.
Biomarkers of Growth Faltering and Neurodevelopmental Delay in
Children who are HIV-Exposed but Uninfected: A Systematic Review
Authors: Sirajee Reshma , Brophy Jason , Conroy Andrea L. , Namasopo Sophie , Opoka Robert O. , Rai Urvi , Forgie Sarah , Salami Bukola O. , Hawkes Michael T.
Published: May 2023

Introduction:

Children who are HIV-exposed but uninfected (CHEU) are at risk of linear
growth faltering and neurodevelopmental delay. Circulating biomarkers associated with these adverse
outcomes may elucidate pathways of injury.

Objective:

To identify biomarkers associated with growth faltering and neurodevelopmental delay
in CHEU.

Methods:

We performed a systematic review of electronic databases MEDLINE (1946-April 2021),
EMBASE (1974-April 2021), Scopus (2004-April 2021), and PubMed (1985-April 2021), following
the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The systematic
review was registered on the International Prospective Register of Systematic Reviews
(PROSPERO, registration number CRD42021238363).

Results:

We found seven studies associating biomarker abnormalities and growth outcomes in
CHEUs and two studies on biomarker abnormalities and neurodevelopmental delay. Biomarker abnormalities
associated with growth restriction were: C-reactive protein (CRP), tumour necrosis factor
(TNF), interferon-gamma (IFN-γ), interleukin (IL)-12p70, IFN-γ-induced protein-10
(CXCL10/IP-10), lipopolysaccharide binding protein (LBP), insulin-like growth factor-1 (IGF-1),
and IGF-binding protein-1 (IGFBP-1). Biomarkers associated with motor, language, and cognitive
delay were CRP, IFN-γ, IL-1β, -2, -4, -6, -10, -12p70, neutrophil gelatinase-associated lipocalin
(NGAL), granulocyte-macrophage colony-stimulating factor (GM-CSF), and matrix metalloproteinase-
9 (MMP-9).

Conclusion:

Elevated markers of inflammation (acute phase reactants, pro-inflammatory cytokines,
chemokines) and intestinal microbial translocation are associated with growth faltering. Elevated
markers of inflammation are associated with adverse neurodevelopment.
Synthesis and Self-assembly of a Novel Amphiphilic Tri-arm Star-shaped Copolymer Poly(ethylene oxide)-b-Poly(ε-caprolactone)
Authors: Zhang Xiaoyan , Kang Kexin , Wu Tao
Published: May 2023

Amphiphilic tri-arm star-shaped copolymers, poly(ethylene oxide)-b-poly(ε-caprolactone) PEO3-b-PCL3, with different poly (ε-caprolactone) (PCL) molecular weights were successfully synthesized by ring-opening polymerization (ROP). Firstly, the tri-arm star-shaped PEO3 was prepared by ROP of trimethylolpropane and ethylene oxide (EO). The ring-opening polymerization (ROP) of ε- caprolactone (CL) was initiated using the tri-arm star-shaped PEO3 with the hydroxyl group as macroinitiator and Sn(Oct)2 as a catalyst. Amphiphilic tri-arm star-shaped copolymers PEO3-b-PCL3 were obtained. By changing the ratio of monomer and macroinitiator, a series of PEO3-b-PCL3 were prepared with a well-defined structure, molecular weight control, and narrow molecular weight distribution. The expected intermediates and final products were confirmed by 1H NMR and Gel Permeation Chromatography (GPC) analyses. In addition, the sizes and morphologies of the obtained micelles with different PCL segment lengths were investigated with dynamic light scattering (DLS) and transmission electron microscopy (TEM), respectively. It was found that the self-assembly morphologies were spherical micelle in aqueous solution.
Analysis of Ultrasound Supported Antimicrobial and Antibiofilm Activities
of Disinfection By-product Bromochloroacetonitrile
Authors: E.R. Sevda
Published: May 2023

Introduction:

Some microorganism threaten human health by forming biofilm in water systems. Because microorganism in the biofilm structure are more resistant to antimicrobials.

Methods:

Water systems are disinfected with physical methods, such as ultrasonication techniques and chemical disinfectants. Bromochloroacetonitrile is produced as a by-product from algae and fulvic acid sources during water chlorination. This study aimed to investigate the antimicrobial and antibiofilm effects of bromochloroacetonitrile on some bacteria alone and with ultrasound treatment.
The study used Escherichia coli ATCC 25922, Klebsiella pneumoniae MCTC 13438, and Staphylococcus aureus ATCC 25923 strains. The antimicrobial and antibiofilm activities of the test substance were analyzed alone with bromochloroacetonitrile and Ultrasound-assisted. Minimum Inhibitory Concentration values of the test substance against Escherichia coli ATCC 25922, Klebsiella pneumoniae MCTC 13438, and Staphylococcus aureus ATCC 25923 strains were 25, 25 and 50 mM, respectively, and Minimum Bactericidal Concentration values were 50, >50, and >50 mM, respectively.

Results:

The obtained data show that bromochloroacetonitrile is a potential disinfection agent that can be used against biofilm formation in water systems. Besides, it was revealed that when ultrasound treatment was applied with bromochloroacetonitrile, it showed 100% antibiofilm activity on E. coli and K. pneumoniae and 79.45% antibiofilm activity on S. aureus strains. The obtained data show that bromochloroacetonitrile is a potential disinfection agent that can be used against biofilm formation in water systems. This study is preliminary and planned to reveal the cytotoxic effects of bromochloroacetonitrile on healthy human skin and liver cells in the following study.

Conclusion:

These results will contribute to the literature, as no study reveals the antimicrobial and antibiofilm activities of bromochloroacetonitrile.
Design, Synthesis and Cytotoxic Studies of Novel 4-anilinoquinazoline Derivatives of Potential Agents for Non-small-cell Lung Cancer
Authors: Dwivedi Deepak K. , Agrawal Ram Kishore , Jain Sanyog , Kuche Kaushik
Published: May 2023

Background:

The pre-existing EGFR (Epidermal Growth Factor Receptors) inhibitors (Gefitinib,
Afatinib and osimertinib) show significant resistance after one year of EGFR therapy in NSCLC
(Non-small cell lung cancer) patients. With the aim of overcoming the resistance problem associated with
a current therapeutic regimen, there is an imperative need for the development of novel 4-
anilinoquinazoline derivatives that are specifically designed for resistance cases of NSCLC patients.

Objective:

We designed and synthesized eighteen 4-anilinoquinazolines derivatives as a novel scaffold
and evaluated their anti-cancer potential against different NSCLC cell lines.

Methods:

Molecular docking study of designed compounds were performed on Glide v5.8 (Schrodinger,
LLC, New York, NY). Synthesis of 4-anilinoquinazoline derivatives were performed, based on the docking
score and was characterized by various spectroscopic methods. Further, in vitro anti-cancer activity
was performed using MTT assay on different cancer cell lines.

Results:

Molecular docking analysis [EGFRT790M mutant (4I22)] indicated that most of these analogs (6g,
6j, 6l, 6m and 6o) were found to be higher docking scores than gefitinib. Furthermore, spectral analysis
revealed that the designed compounds were synthesized successfully. The compounds 6a, 6d, 6g, 6i, 6j
and 6m were identified as the potent inhibitors against (A431, H1975, A549) cell lines as compared to
reference standard gefitinib. Excitingly, compound 6j (with IC50 values of 4.88 ± 0.13, 4.38 ± 0.08 &
11.97 ± 0.14 μM) was identified as the most potent inhibitor for (A431, H1975, A549) cell lines.

Conclusion:

The study suggested that the six derivatives showed significant therapeutic potential against
different NSCLC cell lines as compared to reference standard gefitinib.
Zinc Acetate in Organic Synthesis and Catalysis: A Review
Authors: Alam Mohammed Mujahid , Varala Ravi , Seema Vittal
Published: May 2023

Among the many zinc salts that can be found, zinc acetate is one of the readily available,
affordable, low-hazardous Lewis acids. It can be referred to as a multifunctional catalyst due to its
unique physical and chemical properties, which show that they are effective in enabling a variety of
synthetic transformations in both organic synthesis and catalysis. This review included noteworthy
innovations that have been created during the past two and half decades using zinc acetate as a catalyst
or reagent.
The Decline in the Age of Onset of Puberty – A Source of Concern
Authors: Mangla Mishu
Published: May 2023

Puberty refers to physical transitions that occur in the body of adolescents, taking them
from a stage of sexual immaturity to sexual maturity. Nowadays, it is being observed that more and
more girls are attaining menarche at an age less than ten years, so the age of onset of Puberty being
somewhere around 7.5 to 8 years. The reasons and implications are manifold. Early age of onset of
puberty is a risk factor for ovarian and breast malignancies and also for a number of chronic diseases.
The present article expresses author’s opinion regarding the issue on the basis of recent literature and
tries to highlight the reasons responsible for this, especially in the current scenario and discusses modifiable
factors so that the process can be halted.
Legal-Jurisprudential Protection of Women in Cases of Spousal Unauthorized
Psychological-Verbal Domestic Violence, A Narrative Review
Study
Authors: Ghodrati Fatemeh
Published: May 2023

Background:

Intimate partner violence [IPV) in all its physical, mental, overt and covert
forms is an important issue in terms of its consequences.

Objective:

This study aimed to provide legal-jurisprudential support for women in cases of spousal
abuse and unauthorized psychological violence.

Material and Methods:

This review article is the result of reviewing the published evidence on the
supportive aspects of unauthorized psychological-verbal IPV between 1995 and 2021 in Magiran,
SID, Iranmedex Persian databases, and in Scopus, PubMed, Science Direct, and EBSCO English databases. To gather information first, articles and jurisprudential texts containing one of the words “verbal violence, domestic violence, spousal abuse, legal protection of women, law, Islam” in the title or
text, alone or in combination, were searched for.

Results:

Twenty-three out of 58 studies related to legal-jurisprudential support for women in Iran in
cases of psychological-verbal IPV were reviewed. Verbal psychological IPV, attack on the spiritual
status of the wife, accusing the wife of sexual infidelity, insulting, using inappropriate instincts, harshness, humiliation, intimidation and misbehavior, the verbal threat of harassment, and even threat of
murder, etc., were the instances of such violence. The Shari’a supported the wife with punishments of
Solemn Imprecation, imprisonment, lashes, and fines.

Conclusion:

In addition to the current legal solutions, the main legal gap that causes the ineffectiveness of laws and the violation of women’s rights is the solution and removal of obstacles that, in practice and in court, have made it difficult to prove psychological-verbal violence against women at
home.
Mechanistic Role of Tempol: Synthesis, Catalysed Reactions and
Therapeutic Potential
Authors: Tiwari Abhishek , Tiwari Varsha , Banik Bimal Krishna , Sahoo Biswa Mohan
Published: May 2023

Tempol (TP) was introduced in 1960 by Lebedev and Kazarnovskii and is an excellent
catalyst extensively used in the synthesis and oxidation of various reagents. 4-Hydroxy-2,2,6,6-
tetramethylpiperidin-1-oxyl (TP) has also been explored against various disorders like inflammation,
superoxide anion-influenced molecular linked behavioural modifications, radical capturing, cardioprotective,
protective ocular damage, against skin burns, fibrocystic diseases, breast cancer prevention,
respiratory infections, alopecia, and cerebral malaria, etc. This review article comprises five
major aspects of TP namely (a) Approx. 25 different Synthesis schemes of TP (b) major reactions
catalysed by TP (c) Therapeutic potential of TP. It also provides scientific information that supports
the use of TP which may be proven as a “MIRACLE” drug for the treatment of numerous disorders
namely in reducing the reactive oxygen species, superoxide mutases, vision disorders, cancer as well
as in covid. It also possesses a significant role in minimising side effects in combination therapy.
This review will be beneficial to researchers, healthcare, and academic professionals for further
research.
A Complete Sojorum on Thermosensitive Hydrogels for Wound Healing:
Recent Developments and Ongoing Research
Authors: Markandeywar Tanmay Sudhakar , Singh Dilpreet , Narang Raj Kumar
Published: May 2023

The nature of the wound typically dictates the available wound-healing therapies. On the
other hand, inadequate care results in persistent wounds, fibrosis, tissue loss of function, and ultimately
dismemberment. Suturing, unloading, irrigation, debridement, negative pressure therapies, growth
factor supplementation, and grafting are examples of current medicines that all have limitations in
terms of meeting the needs of full treatment. Natural or synthetic materials/polymers have been utilized
to prepare smart thermosensitive hydrogels to facilitate quick and targeted action on wounds.
These are intelligent hydrogel system that shows sol-gel transitions at physiological body temperature.
Hydrogel provides a moist environment, scaffold-like structure, and localized delivery of drug/growth
factor that speed up wound healing even if it eliminates side effects associated with systemic administration.
In this article, we summarized the detailed mechanisms of wound healing, conventional
strategies, and ongoing thorough research work in the field of thermosensitive hydrogels utilized for
wound healing. Moreover, the clinical needs of this formulation, as evident from the commercially
available systems are also described in the prior art.
Patent Technology of Shipborne Stabilized Platform
Authors: Zou Yuxin , Liu Hongbo , Liu Xianli , Yang Xiao Dong
Published: May 2023

Background:

When a ship is sailing or operating at sea, it is unavoidable to produce sixdegrees-
of-freedom movements of rolling, pitching, and yawing under the action of sea wind and
waves, which seriously impacts the operation of precision equipment on the ship and the safety of
personnel. The ship-borne stabilized platform can isolate the ship's motion and eliminate the impact
of sea waves on the personnel and equipment on it to a large extent. With the increasing demand for
ship surfaces in marine fields, such as navigation equipment, military facilities, and sea condition
simulation, there is an urgent need to study ship-borne platforms with high stability and efficiency
to isolate swaying and ensure ship performance.

Objective:

This study aims to analyse the patents and summarize the characteristics and existing
problems of the shipborne platform to provide a reference for the future development of the shipborne
stabilized platform.

Methods:

Various representative patents related to shipborne stabilized platforms and multi-DOF
platforms were researched in this study.

Results:

Through the analysis and comparison of patent technology, the main problems existing in
the structure and design principle of the existing shipborne stabilized platform are summarized, and
the development trend and direction of the shipborne stabilized platform are discussed.

Conclusion:

Shipborne stabilization is highly significant in isolating the ship's motion. At present,
the ship-borne stabilized platform has produced six degrees of freedom of movement, but due to the
improvement of control response requirements, the structure of the platform needs to be further improved.
With the development of test technology toward intelligent and big data-driven technology,
the shipborne stabilized platform is moving toward cloud computing and large-scale testing.
Biosurfactants for Biodégradation
Authors: Alia Telli
Published: May 2023

The low toxicity, biodegradability, powerful surface activity, and the
functionality under extreme conditions (pH, salinity and temperature) make the
surfactants produced by micro-organisms (bacteria, fungi, and yeasts) best surface active molecules that can replace hazardous and non degradable chemical surfactants in
different industries and fields. In recent decades, there has been growing interest in the
use of biosurfactants for bioremediation of environmental pollution and biodegradation
of various categories of hydrophobic pollutants and waste due to their eco-friendly and
low-cost properties. This chapter presents the classification, the characteristics, and the
potential uses of biosurfactants in the solubilization and enhancing the biodegradation
of low solubility compounds.
Microbial Bioremediation of Microplastics
Authors: Kumar Singh Manish , Raza Beg Younus , Nishad Gokul Ram , Singh Priyanka
Published: May 2023

Plastic is being used over the entire globe in the form of capsules,
microbeads, fibers or microplastics. The waste thus generated has gained concern due
to the loss of aesthetic value, the presence of various toxic chemicals such as
plasticizers, antioxidants, etc., and the release of greenhouse gases. The small size and
slow degradability of microplastics are responsible for their accumulation in the
environment and organisms. Plastic degradability can be improved by altering its
chemical and physical structure or using better degrading agents. Different types of
microorganisms and enzymes are being designed and employed for degrading plastic
waste. This chapter gives an overview of the degradation mechanism along with
different microbial, plant and animal species responsible for this process. 
Microbial Degradation of Plastics
Authors: Geetanjali  , Singh Vikram , Singh Ram
Published: May 2023

The essentiality of plastics in our daily life is inseparable. Almost all
industrial sectors utilize plastics either directly or indirectly. But the downside of
plastics also increased simultaneously. These materials increased water and soil
pollution due to unmanaged discharge. Hence, plastic waste treatment becomes
essential for a sustainable and efficient environment. Plastic recycling and degradation
are two processes to deal with plastic waste. Out of the three degradation processes,
physical, chemical, and biological, biological degradation is near to a sustainable
environment. Recent studies revolve around the use of micro-organisms for the
degradation of plastics. The present chapter reports the microbial degradation of plastic
waste using bacteria and fungi. The discussion also includes the impact of plastic
properties and environmental factors on biodegradation.
Compressed Video-Based Classification for Efficient Video Analytics
Authors: Sangeeta  , Gulia Preeti , Singh Gill Nasib
Published: May 2023

Videos have become a crucial part of human life nowadays and share a large
proportion of internet traffic. Various video-based platforms govern the mass
consumption of videos through analytics-based filtering and recommendations. Various
video-based platforms govern their mass consumption by analytics-based filtering and
recommendations. Video analytics is used to provide the most relevant responses to our
searches, block inappropriate content, and disseminate videos to the relevant
community. Traditionally, for video content-based analytics, a video is first decoded to
a large raw format on the server and then fed to an analytics engine for metadata
generation. These metadata are then stored and used for analytic purposes. This
requires the analytics server to perform both decoding and analytics computation.
Hence, analytics will be fast and efficient, if performed over the compressed format of
the videos as it reduces the decoding stress over the analytics server. This field of
object and action detection from compressed formats is still emerging and needs further
exploration for its applications in various practical domains. Deep learning has already
emerged as a de facto for compression, classification, detection, and analytics. The
proposed model comprises a lightweight deep learning-based video compression-cum classification architecture, which classifies the objects from the compressed videos into
39 classes with an average accuracy of 0.67. The compression architecture comprises
three sub-networks i.e. frame and flows autoencoders with motion extension network to
reproduce the compressed frames. These compressed frames are then fed to the
classification network. As the whole network is designed incrementally, the separate
results of the compression network are also presented to illustrate the visual
performance of the network as the classification results are directly dependent on the
quality of frames reconstructed by the compression network. This model presents a
potential network and results can be improved by the addition of various optimization
networks.
Object Detection and Tracking: Exploring a Deep Learning Approach and Other Techniques
Authors: Oluyemi Owoeye Samuel , Durodola Folasade , Odeyemi Jethro
Published: May 2023

Object detection and tracking have a wide range of uses, for example, in
security and surveillance systems to deter and investigate crimes, for traffic monitoring,
and for communication through video sharing. In a smart city, data is continuously
being obtained through various means. In terms of video data, the data collected
through cameras and other digital devices need to be analyzed to derive useful
information from it. Hence, the concept of object detection and tracking comes into
play. This chapter looks into developing various frameworks for object detection and
tracking in the context of video data. We will be working with a database of 1,939
pencil images. These images will be used to train a neural network that performs image
classification tasks. Various object detection methods are implemented such as
Convolution Neural Network (CNN) image classification, Canny edge detection, object
detection using the Haar Cascade classifier, and background subtraction. The
experiments are carried out with Python programming language, TensorFlow, and
OpenCV library.
A Review of Progress Status in Achieving the Jal Jeevan Mission Goals in the State of Chhattisgarh
Authors: Rahamatkar Surendra , Patnaik Sweta , Patnaik Satyendra
Published: May 2023

The water governance process is seen as a mechanism to solve both the deficiencies of the broader governance process and the Millennium Development Goals (MDGs). Millions of people in India rely on unstable, low-quality water supplies that are expensive and far from their homes. Water scarcity has a wide range of socioeconomic consequences. Women and girls are typically entrusted with the responsibility of collecting water for domestic purposes. Providing rural communities with piped water for drinking and domestic needs is an important and difficult endeavor. In light of the above Amity University Chhattisgarh partnering with UNICEF Chhattisgarh is entrusted with the responsibility of providing technical & monitoring support to the Mission Directorate, Jal Jeevan Mission (JJM), and Public Health & Engineering Department (PHED), Government of Chhattisgarh along with Institutional Capacity Building, planning, monitoring and reporting for effective implementation of safe rural drinking water facilities across the Chhattisgarh State.

Materials and Methods: In this perspective, the prime objective of the project was to strengthen the institutional capacity building, and program monitoring in 28 districts of Chhattisgarh through the establishment of the State Program Management Unit (SPMU) at the Directorate of Jal Jeevan Mission (JJM) and Project Management Unit (DPMU) at 14 district levels with light support to 14 additional districts. The method used for data collection was primary and secondary. The findings of the study are presented in suitable tables and graphs.

Results: Results of the study show the progress in solving drinking water problems in rural areas of Chhattisgarh since the inception of the monitoring project i.e. 1st June 2021.

Conclusion: In this paper, an attempt has been made to report the progress of the implementation of the JJM scheme in partnership with UNICEF Chhattisgarh.
Social reality in communication in rural areas
Authors: Peñarrieta-Muñoz Yandry Javier , Moreira-Morales Sabina Eroina , Candela-Muñoz Ulfrido Siffrido , Alcívar-Moreira Mirla Katherine , Zambrano-Villegas Yenny Alexandra
Published: May 2023

Social reality is the construction that arises from the interaction of individuals in a specific context, many students from rural areas operate in environments that can affect their integral development, a situation where emphasis is placed on promoting communication as a support element. The objective of the study is to determine the relationship between social reality and communication in rural areas. The methodology is mixed, integrated by qualitative and quantitative methods. The technique used was the student survey and documentary analysis. The study population was made up of 105 high school students from the Dr. Carlos Romo Educational Unit. The results reflect that in the rural area there are risk factors that can affect the learning and integrity of the students. It is concluded in the importance of communication between school and family to face these situations.
RESEARCH OF PHYSICO-CHEMICAL PROPERTIES OF “JAMU” POWDER FROM MORINGA LEAF, BELUNTAS LEAF, AND NONI LEAF EXTRACTS
Authors:   Universitas Pembangunan Nasional Veteran Jawa Timur, Priyambodo Angelica Apnia , Rosida Dedin Finatsiyatull ,   Universitas Pembangunan Nasional Veteran Jawa Timur
Published: May 2023

Jamu has been used by Indonesian people for generations. Noni, Moringa, and Beluntas leaves have the potential to be utilized as herbal medicine because they contain natural antioxidants such as alkaloids, anthraquinones, tannins, flavanoids. ascorbic acid, and phenolics. Maltodextrin and gum arabic are fillers commonly used in the manufacture of powdered beverages. Gum arabic has a great emulsifying property, but it is relatively expensive. Meanwhile, maltodextrin is a good encapsulant, but its properties as an emulsifier are not good. The purpose of this research was to determine the effect herbal leaf sources (moringa, noni, beluntas) as well as the proportion of maltodextrin and gum arabic on the physical and chemical properties of herbal powder drinks. This research used a 2 Factorial Completely Randomized Design (CRD) with 2 (two) replicates. The results obtained in herbal powder drinks have a moisture content of 3.05-4.05%, ash content of 0.35-1.24%, vitamin C content of 39.45-210.59 mg/100g, solubility of 78.94- 82.91%.
LEPROSY NEUROPATHY
Authors: Prachika Fahrani Yossa , Kurniawan Shahdevi Nandar
Published: May 2023

Leprosy is a major cause of peripheral neuropathy in developing countries, affecting sensory, motor, and autonomic nerve function. Neuropathy complications can include sensory loss and muscle weakness. Impaired sensory nerve function is often the first symptom encountered in leprosy neuropathy. Early detection and treatment of neuropathy in leprosy are important to prevent disability.
Aquisição das vogais orais tónicas por aprendentes chineses com proficiência intermédia-alta no português europeu como língua segunda
Authors: Duan Hongrui , Castelo Adelina , Freitas Maria João
Published: May 2023

No processo de aquisição do Português Europeu (PE) por falantes nativos do Chinês Mandarim (CM), vários desafios fonéticos e fonológicos se colocam, sendo uma das maiores dificuldades a aquisição dos pares contrastivos /e, ɛ/, /o, ɔ/. Para identificar as dificuldades na aprendizagem destas vogais por alunos chineses, o presente estudo-piloto centra-se nas vogais /e/, /ɛ/, /o/ e /ɔ/ produzidas em posição tónica, em diferentes condições experimentais (tarefas de nomeação, de descrição, de repetição e de leitura); as informantes observadas são chinesas, estudam português como língua segunda (L2) e têm nível intermédio-alto de proficiência linguística. Os resultados evidenciam a aquisição problemática dos contrastes vocálicos /e, ɛ/ e /o, ɔ/, sendo a Altura de Vogal a propriedade mais problemática, com as vogais médias [e, o] associadas a taxas de sucesso baixas. Observou-se, ainda, uma maior quantidade de produções corretas das labiais do que das coronais e um melhor desempenho nas tarefas de repetição, de leitura e de nomeação do que na de descrição. Transferência do conhecimento linguístico prévio (CM), princípios universais e caraterísticas fonológicas da língua-alvo (PE) são evocados na discussão sobre o que condiciona o desempenho das informantes. Com base nos dados recolhidos e nas hipóteses sobre as causas a estas subjacentes, defende-se a relevância de uma instrução explícita sobre a pronúncia das vogais /e/, /ɛ/, /o/ e /ɔ/ em níveis avançados de ensino-aprendizagem de português como L2, da análise acústica como ferramenta de aprendizagem da pronúncia e da realização de tarefas de fala controlada e espontânea.
Desenvolvimento das habilidades de consciência fonológica em inglês (L2) no uso da plataforma Lexia Core5 Reading: uma análise de processo a partir da teoria de sistemas dinâmicos complexos
Authors: Costa Cruz Marion , Kickhöfel Alves Ubiratã
Published: May 2023

A partir de uma metodologia de análise ancorada na Teoria dos Sistemas Dinâmicos Complexos, o presente trabalho apresenta uma análise de processo do desenvolvimento das habilidades de consciência fonológica em língua inglesa de um aluno do 3.º ano do Ensino Fundamental de uma escola brasileira com uma proposta bilíngue (Português-Inglês) de ensino. Visando ao desenvolvimento das habilidades fonológicas do aprendiz, a referida escola adotou a plataforma online Lexia Core5 Reading (Lemire, 2021). Para a análise longitudinal deste trabalho, foram empregados dois métodos de análise dinâmica de dados: análises de pico com simulações de Monte Carlo e Correlações Móveis. Os resultados das referidas análises demonstraram o progresso do aprendiz ao longo do período estudado, além de revelarem as tarefas que se mostraram mais dificultosas ao longo do processo.
Effect of task type on the use of discourse markers in L2 Portuguese by L1 Chinese learners
Authors: Yang Aoran , Li Qinxue
Published: May 2023

In an attempt to analyze the effect of different oral tasks on the use of discourse markers (DMs) in second language (L2) Portuguese by first language (L1) Chinese speakers at different L2 proficiency levels, the current study is oriented by two research questions: (1) in what way does L2 proficiency of L1 Chinese speakers influence the use of DMs in Portuguese across tasks in terms of the frequency and variety of different DM classes? (2) how does oral task type affect the use of DMs by L1 Chinese speakers of L2 Portuguese in terms of the frequency and variety of different DM classes? Data for the present study were collected by using two oral tasks, conversation task and narrative task, conducted by 12 Chinese speakers of Portuguese at a lower and higher L2 proficiency levels. Results showed that the Chinese speakers tended to use the DMs in L2 Portuguese at a higher rate and wider variety when they were asked to perform the conversation task and the use of some DM categories seems not to stay correlated with the L2 proficiency levels across tasks.
O texto literário como recurso didático para o ensino-aprendizagem de PLE: pressupostos, desafios e propostas
Authors: Ramón Macaela
Published: May 2023

O português é a língua usada por uma vasta comunidade de autores de todo o espaço lusófono para a criação das suas obras literárias. Deste modo, o texto literário afigura-se como um recurso particularmente útil para o processo de ensino-aprendizagem de Português Língua Estrangeira (PLE), porquanto permite o contacto natural e autêntico com este idioma pluricêntrico, evidenciando a sua diversidade ao nível linguístico e cultural. No plano linguístico, os textos literários lusógrafos permitem dar a conhecer as distintas variedades do português; no plano cultural, abrem amplas perspetivas de conhecimento e de reflexão, recusando o etnocentrismo. Neste artigo, sintetizam-se alguns pressupostos teóricos relativos ao uso do texto literário para a aprendizagem de PLE, reflete-se sobre os desafios que tais textos colocam e apresentam-se sugestões didáticas para a sua inclusão na prática docente, a partir de um poema do autor timorense Fernando Sylvan.
Conhecimento linguístico e gêneros discursivos digitais: correlações possíveis a partir de fenômenos variáveis em interações por chat
Authors: Ferreira de Carvalhaes Pinheiro Andrei , Paredes Silva Vera , Abreu Gomes Christina
Published: May 2023

Diversos estudos sobre a língua inglesa têm verificado, na comunicação informal por ambiente digital, estratégias de redução ou simplificação sintática, entre as quais se atesta a não expressão do sujeito de 1.ª pessoa do singular. Este artigo focaliza um gênero discursivo digital com o objetivo de verificar se a língua usada no ambiente digital se diferencia dos usos observados na fala e na escrita convencionais, ao incorporar diferentes frequências de variantes morfossintáticas. São analisados dados das variáveis realização do sujeito pronominal de 1.ª pessoa do singular e do objeto direto anafórico de 3.ª pessoa do português brasileiro. Os dados foram coletados de interações por chat (ou mensagens instantâneas), tipicamente informais. Os resultados indicam a predominância das variantes nulas para ambas as variáveis, reproduzindo taxas atestadas para a realização do sujeito na escrita e para a realização do objeto direto anafórico na fala. Dessa forma, constitui-se um padrão específico do gênero discursivo digital analisado. A partir da abordagem dos Modelos baseados no Uso, buscamos argumentar que os padrões observados nos gêneros discursivos, incluindo os digitais, também integram o conhecimento linguístico do falante.
Marañón: un acercamiento al contexto productivo, social, ambiental y agroindustrial en la altillanura de Vichada.
Authors: Cano Fidel , Rincón Reina Alexander , González Chavarro Carlos Felipe , Mateus Cagua Diana , Orduz Rodríguez Javier Orlando , Pisco Yeinny Carolina
Published: May 2023

La lectura de este documento le permitirá tener una visión sencilla pero amplia del cómo se ha venido construyendo el proceso agrícola, industrial y cultural, cuáles son los logros y problemas, y con mayor importancia los desafíos futuros. Este esfuerzo mancomunado que arranca hace años con unos pocos, y que en el andar del tiempo nos ha permitido ir sumando productores y empresarios convencidos de las ventajas comparativas de Vichada, es la base fuerte que respalda la meta propuesta de llegar a 100.000 hectáreas para el año 2030 y convertir al departamento de Vichada en el mayor exponente de la producción sostenible para exportación.
https://repository.agrosavia.co/handle/20.500.12324/37345
Authors: Lerma Lasso Jose Libardo , Meneses Buitrago Diego Hernán , Castro Rincon Edwin
Published: May 2023

Ante los interrogantes que tienen los productores ganaderos de lechería especializada de trópico alto del departamento de Nariño sobre cuáles son los volúmenes de agua requeridos para la producción de biomasa como pasturas o praderas, y en función de las condiciones agroclimáticas de la región cuál es el nivel o potencial para la producción de biomasa, la Corporación Colombiana de Investigación Agropecuaria – AGROSAVIA, por medio del manual Gestión eficiente del recurso hídrico en predios ganaderos del trópico alto nariñense, propone alternativas y recomendaciones para resolver dichos interrogantes y mejorar la competitividad y sostenibilidad del sistema productivo.
Adherence to Patient-Reported Symptom Monitoring and Subsequent Clinical Interventions for Patients With Multiple Myeloma in Outpatient Care: Longitudinal Observational Study
Authors: Lehmann Jens , de Ligt Kelly M , Tipelius Stefanie , Giesinger Johannes M , Sztankay Monika , Voigt Sandra , van de Poll-Franse Lonneke V , Rumpold Gerhard , Weger Roman , Willenbacher Ella , Willenbacher Wolfgang , Holzner Bernhard
Published: May 2023

Background

The use of software to monitor patient-reported outcome measures (PROMs) can improve outcomes for patients with cancer receiving anticancer therapy; however, evidence from applications used in routine clinical practice is lacking.

Objective

We aimed to investigate adherence to and patient perceptions of a weekly, web-based PROM symptom monitoring program in routine clinical practice for patients with Multiple Myeloma. Moreover, we aimed to capture how clinical alerts prompted by the system influenced clinical care.

Methods

We conducted a single-center longitudinal observational study to evaluate patient adherence to and perceptions of the PROM monitoring software in routine practice. Patients with Multiple Myeloma remotely completed weekly treatment-specific PROMs to monitor key symptoms via a dedicated web-based platform. Alarming symptoms triggered clinical alerts in the application for the treatment team, which could initiate clinical interventions. The primary outcomes were the web-based assessment completion rate and patients’ perceptions of the monitoring program, as assessed by an evaluation questionnaire. Moreover, clinical alerts prompted by the system and consequential clinical interventions were analyzed.

Results

Between July 2021 and June 2022, a total of 55 patients were approached for participation; 39 patients participated (24, 61% male, mean age 63.2, SD 9.2 years). The median assessment completion rate out of all weekly scheduled assessments was 70.3% (IQR 41.2%-89.6%). Most patients (77%) felt that the health care team was better informed about their health status due to the web-based assessments. Clinical alerts were triggered for 1758 of 14,639 (12%) reported symptoms. For 548 of 1758 (31.2%) alerts, the symptom had been registered before and no further action was required; for 348 of 1758 (19.9%) alerts, telephone consultation and self-management advice sufficed. Higher-level interventions were seldom needed in response to alerts: referral to a doctor or specialist (88/1758, 5% alerts), medication changes (22/1758, 1.3%), scheduling additional diagnostics (9/1758, 0.5%), or unplanned emergency visits (7/1758, 0.4%). Most patients (55%) reported the calls in response to alerts gave them “quite a bit” or “very much” of an added feeling of security during therapy.

Conclusions

Our study shows that high adherence to regular and tailored PROM monitoring can be achieved in routine clinical care. The findings provide valuable insight into how the PROM monitoring program and the clinical alerts and resulting interventions shaped clinical practice.

Trial Registration

ClinicalTrials.gov NCT05036863; https://clinicaltrials.gov/study/NCT05036863
Methodologies for Monitoring Mental Health on Twitter: Systematic Review (Preprint)
Authors: Di Cara Nina H , Maggio Valerio , Davis Oliver S P , Haworth Claire M A
Published: May 2023

BACKGROUND

The use of social media data to predict mental health outcomes has the potential to allow for the continuous monitoring of mental health and well-being and provide timely information that can supplement traditional clinical assessments. However, it is crucial that the methodologies used to create models for this purpose are of high quality from both a mental health and machine learning perspective. Twitter has been a popular choice of social media because of the accessibility of its data, but access to big data sets is not a guarantee of robust results.

OBJECTIVE

This study aims to review the current methodologies used in the literature for predicting mental health outcomes from Twitter data, with a focus on the quality of the underlying mental health data and the machine learning methods used.

METHODS

A systematic search was performed across 6 databases, using keywords related to mental health disorders, algorithms, and social media. In total, 2759 records were screened, of which 164 (5.94%) papers were analyzed. Information about methodologies for data acquisition, preprocessing, model creation, and validation was collected, as well as information about replicability and ethical considerations.

RESULTS

The 164 studies reviewed used 119 primary data sets. There were an additional 8 data sets identified that were not described in enough detail to include, and 6.1% (10/164) of the papers did not describe their data sets at all. Of these 119 data sets, only 16 (13.4%) had access to ground truth data (ie, known characteristics) about the mental health disorders of social media users. The other 86.6% (103/119) of data sets collected data by searching keywords or phrases, which may not be representative of patterns of Twitter use for those with mental health disorders. The annotation of mental health disorders for classification labels was variable, and 57.1% (68/119) of the data sets had no ground truth or clinical input on this annotation. Despite being a common mental health disorder, anxiety received little attention.

CONCLUSIONS

The sharing of high-quality ground truth data sets is crucial for the development of trustworthy algorithms that have clinical and research utility. Further collaboration across disciplines and contexts is encouraged to better understand what types of predictions will be useful in supporting the management and identification of mental health disorders. A series of recommendations for researchers in this field and for the wider research community are made, with the aim of enhancing the quality and utility of future outputs.

CLINICALTRIAL
EVALUATION OF INCIDENCE OF MALIGNANCY IN SOLITARY THYROID NODULE AT A TERTIARY CARE HOSPITAL
Authors: NOOR ALAM MOHAMMAD , DULANGE VIJAYLAXMI , S. ALAM SADIA AFREEN , PRAMOD
Published: May 2023

Objective: This study aims to identify the incidence of malignancy in solitary nodule thyroid in a tertiary care hospital in Kalaburagi, Karnataka.
Methods: This was a prospective non-randomized hospital-based interventional study carried out on 50 patients over a period of 1 y, who presented with clinically palpable solitary thyroid swellings and subsequently underwent surgery for the same at the Department of General surgery, Gulbarga Institute of Medical Sciences, Kalaburagi, Karnataka.
Results: Over the total duration of the study period, there were 50 cases of clinically detected solitary thyroid nodule with a high female preponderance. The mean age of the incidence of solitary thyroid nodule was 40.6 y. The incidence of malignancy in solitary thyroid nodule was found to be 18%.
Conclusion: It is concluded from the present study that 18% of solitary thyroid nodules are malignant, with female preponderance and a mean age of solitary thyroid nodule is 40.62 y.
A Psychoanalytical Reading of Ibsen’s The Wild Duck
Authors: Gogoi Atlanta
Published: May 2023

Ibsen, as a playwright, as Thomas F. Van Lann comments, has been accused of deceiving his audience regarding the matters of his play- both its central business and its manner; particularly in his style and mode. While reviewing Ibsen through a Lacanian lens, critics such as Oliver W. Gerland III, argue that reading Ibsen is a task of revising interpretative paradigms and that Ibsen’s protagonist revises strategies for enacting the “self”. The Wild Duck (1884), has been critiqued as a poignant drama of illusions, where an idealistic outsider’s gratuitous truth-telling destroys a family. This paper argues that Ibsen’s texts stage the Oedipal crisis in a revised form by taking recourse to Lacan’s re-reading of Freud, where he suggests a paradigmatic triad as a representation of the displaced form of familar Oedipal structure. For Lacan, the Oedipal structure is not a simple love for the mother and hatred for the father, rather it places the child in the realm of the Symbolic, i.e its linguistic association with the father. He argues that the self is rooted in the mirror stage and the infant’s identification with images of coherence and stability- e.g its own reflected image. This paper argues that Ibsen locates his drama in the simples of the Oedipal complex, but revises it. Hjalmar Ekdal’s Imaginary web is disrupted when the idealist Gregers Werle breaks down the Imaginary, invokes the Symbolic authoritarian “no”, and substitutes it with the retelling of Hakon Werle. This paper seeks to accentuate Gregers’ idealism as what Lacan termed as obsessional neurosis and a display of his own lacking in preserving his Imaginary i.e playing a father to his friend and maintaining Hjalmar’s heroic image in his mind, finally resulting in little Hedvig’s suicide.