bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 5 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Authors: Greer Rachel M. , Peyton Michael , Larsen Jill E. , Girard Luc , Xie Yang , Gazdar Adi F. , Harran Patrick , Wang Lai , Brekken Rolf A. , Wang Xiaodong , Minna John D.
Published: April 2023

PDF file - 69K, H1395 cells were transfected with firefly luciferase siRNA, cIAP1 siRNA, cIAP2 siRNA, XIAP siRNA, caspase 3 siRNA, caspase 4 siRNA, caspase 9 siRNA, caspase 8 siRNA, RIPK1 siRNA, TNFR1 siRNA, or cIAP1, cIAP2, and XIAP siRNAs, or treated with JP1201. 24 hours later, cells were harvested and total RNA prepared (RNeasy Plus Mini Kit, 74134, Qiagen, Hilden, Germany). cDNA was synthesized from 1 mg total RNA using the iScript cDNA synthesis kit (BioRad, Hercules, CA). Gene specific TaqMan probes (Applied Biosystems, Foster City, CA) were used to quantitate GAPDH, cIAP1, cIAP2, XIAP, Caspase 3, 4, 8, and 9, RIPK1, TNFR1, and TNFa levels in biological duplicates as well as duplicate samples of siRNA transfected H1395 cells. The 2-DDCT method was used to calculate relative expression levels (19). Expression of target genes were normalized to GAPDH expression, and expression was normalized to H1395 cells transfected with luciferase siRNA. * - indicates where no gene expression data has been determined. ** ND indicates where gene expression was not detected.
Supplementary Methods from Targets of the Tumor Suppressor miR-200 in Regulation of the Epithelial–Mesenchymal Transition in Cancer
Authors: Schliekelman Mark J. , Gibbons Don L. , Faca Vitor M. , Creighton Chad J. , Rizvi Zain H. , Zhang Qing , Wong Chee-Hong , Wang Hong , Ungewiss Christin , Ahn Young-Ho , Shin Dong-Hoon , Kurie Jonathan M. , Hanash Samir M.
Published: April 2023

PDF file - 57K
Supplementary Table 4 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Authors: Greer Rachel M. , Peyton Michael , Larsen Jill E. , Girard Luc , Xie Yang , Gazdar Adi F. , Harran Patrick , Wang Lai , Brekken Rolf A. , Wang Xiaodong , Minna John D.
Published: April 2023

PDF file - 45K, Cells were seeded at 500 cells per well in 6 well dishes. The appropriate concentrations of drug were prepared from stock solutions in medium and given to cells for 10-28 days depending on the cell line. At the end of the assay, medium was aspirated and cells were fixed and stained with 0.5% methylene blue in 50% ethanol for 30 minutes. After staining, wells were washed and black and white images of the plates were taken using a ChemiDoc XRS imager and colonies counted (Quantity One software v4.6.5, BioRad, Hercules, CA). Colony counts are averages of triplicate wells done in triplicate over a two week period. - indicates where no drug sensitivity data has been determined.
Supplementary Figure 2 from Targets of the Tumor Suppressor miR-200 in Regulation of the Epithelial–Mesenchymal Transition in Cancer
Authors: Schliekelman Mark J. , Gibbons Don L. , Faca Vitor M. , Creighton Chad J. , Rizvi Zain H. , Zhang Qing , Wong Chee-Hong , Wang Hong , Ungewiss Christin , Ahn Young-Ho , Shin Dong-Hoon , Kurie Jonathan M. , Hanash Samir M.
Published: April 2023

PDF file - 256K, The most significant networks TGFB containing networks from Ingenuity Pathway Analysis for cellular compartments.
Supplementary Figure 1 from Targets of the Tumor Suppressor miR-200 in Regulation of the Epithelial–Mesenchymal Transition in Cancer
Authors: Schliekelman Mark J. , Gibbons Don L. , Faca Vitor M. , Creighton Chad J. , Rizvi Zain H. , Zhang Qing , Wong Chee-Hong , Wang Hong , Ungewiss Christin , Ahn Young-Ho , Shin Dong-Hoon , Kurie Jonathan M. , Hanash Samir M.
Published: April 2023

PDF file - 296K, The most significant networks from Ingenuity Pathway Analysis networks for cellular compartments.
Supplementary Table 2 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Authors: Greer Rachel M. , Peyton Michael , Larsen Jill E. , Girard Luc , Xie Yang , Gazdar Adi F. , Harran Patrick , Wang Lai , Brekken Rolf A. , Wang Xiaodong , Minna John D.
Published: April 2023

PDF file - 102K, Cell growth assays were performed in 96 well format for 5 days. Cells were plated on day zero and exposed to drug for four days before cell survival was determined using MTS (Promega; final concentration, 333 mg/mL) read at 490 nm 1‐3 hours after addition. Drug sensitivity curves and IC50 were determined using in house software. Data represents average of �3 determinants.
Supplementary Table 1 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Authors: Greer Rachel M. , Peyton Michael , Larsen Jill E. , Girard Luc , Xie Yang , Gazdar Adi F. , Harran Patrick , Wang Lai , Brekken Rolf A. , Wang Xiaodong , Minna John D.
Published: April 2023

PDF file - 674K, Cells labeled with tumor type of NSCLC have an undetermined histotype. Genes listed in the table have mutations in the tumor lines marked with +, determined by sequencing by the Sanger Center (Forbes et al., 2001). Tumor types are as follows, adenocarcinoma (AC), squamous cell carcinoma (SCC), large cell carcinoma (LCC), tumors with undefined histo-subtype are simply labeled as NSCLC.
Supplementary Methods from RNA Helicase DDX5 Is a p53-Independent Target of ARF That Participates in Ribosome Biogenesis
Authors: Saporita Anthony J. , Chang Hsiang-Chun , Winkeler Crystal L. , Apicelli Anthony J. , Kladney Raleigh D. , Wang Jianbo , Townsend R. Reid , Michel Loren S. , Weber Jason D.
Published: April 2023

PDF file - 102K
Supplementary Figure 4 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Authors: Greer Rachel M. , Peyton Michael , Larsen Jill E. , Girard Luc , Xie Yang , Gazdar Adi F. , Harran Patrick , Wang Lai , Brekken Rolf A. , Wang Xiaodong , Minna John D.
Published: April 2023

PDF file - 69K, Western blot analysis of activated caspase 4 after chemotherapy treatment. H1395 cells were treated with 500 nM gemcitabine, 100 nM vinorelbine, or 500 nM thapsigargan (a known ER stress inducer), samples were collected as indicated, protein isolated and analyzed by western blot for HSP90 and caspase 4.
Supplementary Figure 3 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Authors: Greer Rachel M. , Peyton Michael , Larsen Jill E. , Girard Luc , Xie Yang , Gazdar Adi F. , Harran Patrick , Wang Lai , Brekken Rolf A. , Wang Xiaodong , Minna John D.
Published: April 2023

PDF file - 115K, Conditioned medium samples were taken from H2126 (a JP1201 sensitive NSCLC line), and eight other NSCLC cell lines (JP1201 resistant) 12, 24, 48, 72, and 96 hrs after being placed in RPMI with the following treatments: untreated, 10 mM JP1201, 2000 nM gemcitabine, 1000 nM vinorelbine, and 1000 nM vinorelbine with 10 mM JP1201, to test if treatment with chemotherapy can cause TNFa secretion.
Supplementary Figure 2 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Authors: Greer Rachel M. , Peyton Michael , Larsen Jill E. , Girard Luc , Xie Yang , Gazdar Adi F. , Harran Patrick , Wang Lai , Brekken Rolf A. , Wang Xiaodong , Minna John D.
Published: April 2023

PDF file - 671K, A, H358, D, H1819, G, H2887 treated with gemcitabine alone (brown circles), or treated with gemcitabine in the presence of 10 mM JP1201 (red diamonds), luciferase siRNA (black circles), cIAP1 siRNA (blue triangles), cIAP2 siRNA (grey triangles), XIAP siRNA (green squares), or the combination of cIAP1, cIAP2, and XIAP siRNA (orange squares). B, H358, E, H1819, H, H2887 treated with paclitaxel alone (brown circles), or treated with paclitaxel in the presence of 10 mM JP1201 (red diamonds), luciferase siRNA (black circles), cIAP1 siRNA (blue triangles), cIAP2 siRNA (grey triangles), XIAP siRNA (green squares), or the combination of cIAP1, cIAP2, and XIAP siRNA (orange squares). C, H358, F, H1819, I, H2887 treated with vinorelbin alone (brown circles), or treated with vinorelbine in the presence of 10 mM JP1201 (red diamonds), luciferase siRNA (black circles), cIAP1 siRNA (blue triangles), cIAP2 siRNA (grey triangles), XIAP siRNA (green squares), or the combination of cIAP1, cIAP2, and XIAP siRNA (orange squares).
Supplementary Table 3 from Cell-Cycle Regulator Cks1 Promotes Hepatocellular Carcinoma by Supporting NF-κB–Dependent Expression of Interleukin-8
Authors: Lee Eun-Kyoung , Kim Dae-Ghon , Kim Jang-Seong , Yoon Yeup
Published: April 2023

PDF file - 204K
Supplementary Methods, Figures 1-10 from Angiopoietin-1 and -2 Exert Antagonistic Functions in Tumor Angiogenesis, yet Both Induce Lymphangiogenesis
Authors: Fagiani Ernesta , Lorentz Pascal , Kopfstein Lucie , Christofori Gerhard
Published: April 2023

PDF file - 20915K
Supplementary Table 2 from Cell-Cycle Regulator Cks1 Promotes Hepatocellular Carcinoma by Supporting NF-κB–Dependent Expression of Interleukin-8
Authors: Lee Eun-Kyoung , Kim Dae-Ghon , Kim Jang-Seong , Yoon Yeup
Published: April 2023

PDF file - 36K
Supplementary Figure 8 from Cell-Cycle Regulator Cks1 Promotes Hepatocellular Carcinoma by Supporting NF-κB–Dependent Expression of Interleukin-8
Authors: Lee Eun-Kyoung , Kim Dae-Ghon , Kim Jang-Seong , Yoon Yeup
Published: April 2023

PDF file - 80K
Supplementary Tables 1-2 from The RASSF3 Candidate Tumor Suppressor Induces Apoptosis and G1–S Cell-Cycle Arrest via p53
Authors: Kudo Takumi , Ikeda Mitsunobu , Nishikawa Misa , Yang Zeyu , Ohno Kikuo , Nakagawa Kentaro , Hata Yutaka
Published: April 2023

PDF file - 19K, Sup Table 1: This table summarizes the primers for quantitative RT-PCR used in this study. Sup Table 2: This table summarizes the twenty-one-oligomers to knock down various genes used in this study
Supplementary Figure 6 from Cell-Cycle Regulator Cks1 Promotes Hepatocellular Carcinoma by Supporting NF-κB–Dependent Expression of Interleukin-8
Authors: Lee Eun-Kyoung , Kim Dae-Ghon , Kim Jang-Seong , Yoon Yeup
Published: April 2023

PDF file - 97K
Supplementary Figure 4 from Cell-Cycle Regulator Cks1 Promotes Hepatocellular Carcinoma by Supporting NF-κB–Dependent Expression of Interleukin-8
Authors: Lee Eun-Kyoung , Kim Dae-Ghon , Kim Jang-Seong , Yoon Yeup
Published: April 2023

PDF file - 79K
Supplementary Figure 5 from The RASSF3 Candidate Tumor Suppressor Induces Apoptosis and G1–S Cell-Cycle Arrest via p53
Authors: Kudo Takumi , Ikeda Mitsunobu , Nishikawa Misa , Yang Zeyu , Ohno Kikuo , Nakagawa Kentaro , Hata Yutaka
Published: April 2023

PDF file - 148K, This figure demonstrates that RASSF3 regulates cell cycle in HeLa cells and that RASSF3 is involved in UVB- and VP-16-induced G1/S arrest in HeLa cells
Supplementary Figure 2 from Cell-Cycle Regulator Cks1 Promotes Hepatocellular Carcinoma by Supporting NF-κB–Dependent Expression of Interleukin-8
Authors: Lee Eun-Kyoung , Kim Dae-Ghon , Kim Jang-Seong , Yoon Yeup
Published: April 2023

PDF file - 58K
Supplementary Figure 3 from The RASSF3 Candidate Tumor Suppressor Induces Apoptosis and G1–S Cell-Cycle Arrest via p53
Authors: Kudo Takumi , Ikeda Mitsunobu , Nishikawa Misa , Yang Zeyu , Ohno Kikuo , Nakagawa Kentaro , Hata Yutaka
Published: April 2023

PDF file - 137K, This figure demonstrates that RASSF3-induced apoptosis in HeLa cells is p53-dependent
Supplementary Figures 1-9 from A Zebrafish Model to Study and Therapeutically Manipulate Hypoxia Signaling in Tumorigenesis
Authors: Santhakumar Kirankumar , Judson Emma C. , Elks Philip M. , McKee Sarah , Elworthy Stone , van Rooijen Ellen , Walmsley Sarah S. , Renshaw Stephen A. , Cross Simon S. , van Eeden Fredericus J.M.
Published: April 2023

PDF file - 817K, Figure S1 shows in vivo expression of phd3::EGFP in wild-type and vhl-/- Figure S2 shows that phd3::EGFP mRNA expression recapitulates endogenous phd3 expression. Figure S3 shows that EGFP expression in phd3::EGFP embryos is Hif dependent. Figure S4 shows that EGFP expression in phd3::EGFP embryos can be activated by inhibitors of PHD hydroxylases. Figure S5 shows the half life of the fluorescence of the phd3::EGFP line. Figure S6 shows that the phd3::EGFP transgene acts as an in vivo marker for detecting LOH events at the vhl locus in vhl+/- fish. Figure S7 shows morphology of gonadal tumors after DMBA treatment. Figure S8 shows the sequence analysis of the vhl locus in dissected tumors. Figure S9 shows that vhl mRNA levels are decreased in EGFP+ tumors in vhl+/- fish.
Supplementary Figure 4 from The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway
Authors: Wang Yugang , Alam Goleeta N. , Ning Yu , Visioli Fernanda , Dong Zhihong , Nör Jacques E. , Polverini Peter J.
Published: April 2023

PDF file - 88K, Perk-knockout mouse embryonic fibroblasts (MEF) show decreased VEGF expression level upon GD
Supplementary Figure 6 from Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition
Authors: Casás-Selves Matias , Kim Jihye , Zhang Zhiyong , Helfrich Barbara A. , Gao Dexiang , Porter Christopher C. , Scarborough Hannah A. , Bunn Paul A. , Chan Daniel C. , Tan Aik Choon , DeGregori James
Published: April 2023

PDF file - 191K, Western blotting for phosphorylated (Y1068) EGFR, total EGFR, pERK and total ERK in NSCLC cells treated with DMSO, gefitinib and/or Wnt pathway inhibitors, qPCR analyses of Axin-2 mRNA levels in cells in cells treated with canonical Wnt pathway inhibitors, western blotting for activated beta-catenin in stable cell lines, and determination of the ability of activated beta-catenin expression to mitigate the impact of gefitinib and/or XAV939 treatment in HCC4006 NSCLC cells
Supplementary Figure 5 from Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition
Authors: Casás-Selves Matias , Kim Jihye , Zhang Zhiyong , Helfrich Barbara A. , Gao Dexiang , Porter Christopher C. , Scarborough Hannah A. , Bunn Paul A. , Chan Daniel C. , Tan Aik Choon , DeGregori James
Published: April 2023

PDF file - 222K, Demonstration that beta-catenin or TCF-4 knockdown results in enhanced sensitivity of NSCLC cells to gefitinib treatment, that beta-catenin or TCF-4 knockdowns reduce the expression of the corresponding protein, that there is minimal correlation between the expression of canonical Wnt target genes and gefitinib sensitivity for a panel of NSCLC cell lines, that there is no significant correlation of SLuGs with gefitinib induced genes, and that SLuGs are not enriched in lung cancer specific genes
Supplementary Video 2 from Iodide Transporter NIS Regulates Cancer Cell Motility and Invasiveness by Interacting with the Rho Guanine Nucleotide Exchange Factor LARG
Authors: Lacoste Claire , Hervé Julie , Bou Nader Myriam , Dos Santos Alexandre , Moniaux Nicolas , Valogne Yannick , Montjean Rodrick , Dorseuil Olivier , Samuel Didier , Cassio Doris , Portulano Carla , Carrasco Nancy , Bréchot Christian , Faivre Jamila
Published: April 2023

MOV file - 2MB, Time lapse video microscopy of HEK293 cells expressing full-length NIS
Supplementary Video 1 from Iodide Transporter NIS Regulates Cancer Cell Motility and Invasiveness by Interacting with the Rho Guanine Nucleotide Exchange Factor LARG
Authors: Lacoste Claire , Hervé Julie , Bou Nader Myriam , Dos Santos Alexandre , Moniaux Nicolas , Valogne Yannick , Montjean Rodrick , Dorseuil Olivier , Samuel Didier , Cassio Doris , Portulano Carla , Carrasco Nancy , Bréchot Christian , Faivre Jamila
Published: April 2023

MOV file - 1MB, Time lapse video microscopy of HEK293 cells transfected with empty
Supplementary Figure 2 from Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition
Authors: Casás-Selves Matias , Kim Jihye , Zhang Zhiyong , Helfrich Barbara A. , Gao Dexiang , Porter Christopher C. , Scarborough Hannah A. , Bunn Paul A. , Chan Daniel C. , Tan Aik Choon , DeGregori James
Published: April 2023

PDF file - 235K, Validation of shRNA-mediated knockdown of tankyrase-1 expression, demonstration of enhanced NSCLC cell killing by combined inhibition of tankyrase and EGFR in multiple NSCLC cell lines, and specificity of this synergistic cell killing for NSCLC cells with EGFR activation
Supplementary Figure 1 from Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition
Authors: Casás-Selves Matias , Kim Jihye , Zhang Zhiyong , Helfrich Barbara A. , Gao Dexiang , Porter Christopher C. , Scarborough Hannah A. , Bunn Paul A. , Chan Daniel C. , Tan Aik Choon , DeGregori James
Published: April 2023

PDF file - 105K, Graphical representation of shRNA counts obtained by deep sequencing in the screen for synthetic lethality with gefitinib in H322C and HCC4006 NSCLC cells
Supplementary Figures 1-4 from Interleukin-10 Ablation Promotes Tumor Development, Growth, and Metastasis
Authors: Tanikawa Takashi , Wilke Cailin Moira , Kryczek Ilona , Chen Grace Y. , Kao John , Núñez Gabriel , Zou Weiping
Published: April 2023

PDF file - 99K
Supplementary Figure Legends 1-6 from NF-κB Hyperactivation in Tumor Tissues Allows Tumor-Selective Reprogramming of the Chemokine Microenvironment to Enhance the Recruitment of Cytolytic T Effector Cells
Authors: Muthuswamy Ravikumar , Berk Erik , Junecko Beth Fallert , Zeh Herbert J. , Zureikat Amer H. , Normolle Daniel , Luong The Minh , Reinhart Todd A. , Bartlett David L. , Kalinski Pawel
Published: April 2023

PDF file - 17K
Supplementary Figure 4 from NF-κB Hyperactivation in Tumor Tissues Allows Tumor-Selective Reprogramming of the Chemokine Microenvironment to Enhance the Recruitment of Cytolytic T Effector Cells
Authors: Muthuswamy Ravikumar , Berk Erik , Junecko Beth Fallert , Zeh Herbert J. , Zureikat Amer H. , Normolle Daniel , Luong The Minh , Reinhart Todd A. , Bartlett David L. , Kalinski Pawel
Published: April 2023

PDF file - 109K, CCL22 is predominantly expressed by HLA-DR+ APC, whereas CXCL10 and CCL5 are expressed by both HLA-DR positive and negative cells
Supplementary Figure 2 from Potentiation of the Novel Topoisomerase I Inhibitor Indenoisoquinoline LMP-400 by the Cell Checkpoint and Chk1-Chk2 Inhibitor AZD7762
Authors: Aris Sheena M. , Pommier Yves
Published: April 2023

PDF file - 245K
Supplementary Figure 1 from Potentiation of the Novel Topoisomerase I Inhibitor Indenoisoquinoline LMP-400 by the Cell Checkpoint and Chk1-Chk2 Inhibitor AZD7762
Authors: Aris Sheena M. , Pommier Yves
Published: April 2023

PDF file - 111K
Supplementary Methods from Genetic Determinants for Promoter Hypermethylation in the Lungs of Smokers: A Candidate Gene-Based Study
Authors: Leng Shuguang , Stidley Christine A. , Liu Yushi , Edlund Christopher K. , Willink Randall P. , Han Younghun , Landi Maria Teresa , Thun Michael , Picchi Maria A. , Bruse Shannon E. , Crowell Richard E. , Van Den Berg David , Caporaso Neil E. , Amos Christopher I. , Siegfried Jill M. , Tesfaigzi Yohannes , Gilliland Frank D. , Belinsky Steven A.
Published: April 2023

PDf file - 81K
Supplementary Table 3 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma
Authors: Janouskova Hana , Maglott Anne , Leger David Y. , Bossert Catherine , Noulet Fanny , Guerin Eric , Guenot Dominique , Pinel Sophie , Chastagner Pascal , Plenat François , Entz-Werle Natacha , Lehmann-Che Jacqueline , Godet Julien , Martin Sophie , Teisinger Jan , Dontenwill Monique
Published: April 2023

PDF file - 27K, Relationship between Alpha5 mRNA level and p53 status in human biopsies and in human xenografts in nude mice
Supplementary Note 2 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis
Authors: Dulak Austin M. , Schumacher Steven E. , van Lieshout Jasper , Imamura Yu , Fox Cameron , Shim Byoungyong , Ramos Alex H. , Saksena Gordon , Baca Sylvan C. , Baselga Jose , Tabernero Josep , Barretina Jordi , Enzinger Peter C. , Corso Giovanni , Roviello Franco , Lin Lin , Bandla Santhoshi , Luketich James D. , Pennathur Arjun , Meyerson Matthew , Ogino Shuji , Shivdasani Ramesh A. , Beer David G. , Godfrey Tony E. , Beroukhim Rameen , Bass Adam J.
Published: April 2023

PDF file - 88K, Description of Sample Validation
Supplementary Note 1 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis
Authors: Dulak Austin M. , Schumacher Steven E. , van Lieshout Jasper , Imamura Yu , Fox Cameron , Shim Byoungyong , Ramos Alex H. , Saksena Gordon , Baca Sylvan C. , Baselga Jose , Tabernero Josep , Barretina Jordi , Enzinger Peter C. , Corso Giovanni , Roviello Franco , Lin Lin , Bandla Santhoshi , Luketich James D. , Pennathur Arjun , Meyerson Matthew , Ogino Shuji , Shivdasani Ramesh A. , Beer David G. , Godfrey Tony E. , Beroukhim Rameen , Bass Adam J.
Published: April 2023

PDF file - 50K, Description of Combining SNP6.0 and 250K Platforms
Supplementary Figure 2 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma
Authors: Janouskova Hana , Maglott Anne , Leger David Y. , Bossert Catherine , Noulet Fanny , Guerin Eric , Guenot Dominique , Pinel Sophie , Chastagner Pascal , Plenat François , Entz-Werle Natacha , Lehmann-Che Jacqueline , Godet Julien , Martin Sophie , Teisinger Jan , Dontenwill Monique
Published: April 2023

PDF file - 48K, Nutlin-3a decreases the total expression of Beta1 integrin subunit in U87MG cells but not its expression at the cell membrane
Supplementary Figure 1 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma
Authors: Janouskova Hana , Maglott Anne , Leger David Y. , Bossert Catherine , Noulet Fanny , Guerin Eric , Guenot Dominique , Pinel Sophie , Chastagner Pascal , Plenat François , Entz-Werle Natacha , Lehmann-Che Jacqueline , Godet Julien , Martin Sophie , Teisinger Jan , Dontenwill Monique
Published: April 2023

PDF file - 131K, The effect of Alpha5 integrin on p53 activity and resistance to temozolomide is restricted to p53wt expressing cells
Supplementary Figures 1-13 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis
Authors: Dulak Austin M. , Schumacher Steven E. , van Lieshout Jasper , Imamura Yu , Fox Cameron , Shim Byoungyong , Ramos Alex H. , Saksena Gordon , Baca Sylvan C. , Baselga Jose , Tabernero Josep , Barretina Jordi , Enzinger Peter C. , Corso Giovanni , Roviello Franco , Lin Lin , Bandla Santhoshi , Luketich James D. , Pennathur Arjun , Meyerson Matthew , Ogino Shuji , Shivdasani Ramesh A. , Beer David G. , Godfrey Tony E. , Beroukhim Rameen , Bass Adam J.
Published: April 2023

PDF file - 1MB, Supplemental Figures 1-13 - Figure S1. Average levels of focal amplification and deletion along the chromosome arm; Figure S2. Patterns of chromosomal instability differ across adenocarcinomas of the gastrointestinal tract after removing samples without arm-level alterations; Figure S3. Numbers of high-level amplifications and deletions using arm-level based thresholds; Figure S4. Identification of arm-level alterations in esophageal, gastric, and colorectal adenocarcinomas; Figure S5. Comparison of SNP6.0 and 250K adenocarcinoma data to Progenetix database; Figure S6. Significance of focal amplifications in esophageal, gastric, and colorectal adenocarcinomas; Figure S7. Variable levels of focal alterations across gut adenocarcinomas; Figure S8. KRAS alterations differ across gut adenocarcinomas; Figure S9. Quantitative real-time PCR confirms FGFR2 amplification in EA tumors; Figure S10. Focal alterations in gut adenocarcinomas shared with all cancers; Figure S11. Significance of focal deletions in esophageal, gastric, and colorectal adenocarcinomas; Figure S12. Length distribution of SCNAs in gut adenocarcinomas; Figure S13. Observed distribution of copy number event amplitudes in the data set.
Supplementary Figure Legends 1-3 from Effective Combination Therapy for Malignant Glioma with TRAIL-Secreting Mesenchymal Stem Cells and Lipoxygenase Inhibitor MK886
Authors: Kim Seong Muk , Woo Ji Sun , Jeong Chang Hyun , Ryu Chung Heon , Lim Jung Yeon , Jeun Sin-Soo
Published: April 2023

PDF file - 72K
Supplementary Figure 14 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis
Authors: Dulak Austin M. , Schumacher Steven E. , van Lieshout Jasper , Imamura Yu , Fox Cameron , Shim Byoungyong , Ramos Alex H. , Saksena Gordon , Baca Sylvan C. , Baselga Jose , Tabernero Josep , Barretina Jordi , Enzinger Peter C. , Corso Giovanni , Roviello Franco , Lin Lin , Bandla Santhoshi , Luketich James D. , Pennathur Arjun , Meyerson Matthew , Ogino Shuji , Shivdasani Ramesh A. , Beer David G. , Godfrey Tony E. , Beroukhim Rameen , Bass Adam J.
Published: April 2023

PDF file - 340K, Hierarchical clustering of copy-number profiles
Supplementary Figure 3 from Effective Combination Therapy for Malignant Glioma with TRAIL-Secreting Mesenchymal Stem Cells and Lipoxygenase Inhibitor MK886
Authors: Kim Seong Muk , Woo Ji Sun , Jeong Chang Hyun , Ryu Chung Heon , Lim Jung Yeon , Jeun Sin-Soo
Published: April 2023

PDF file - 2.6MB, DR5-mediated cytotoxic effect of combined treatment with AA861 and TRAIL
Supplementary Figure 2 from Effective Combination Therapy for Malignant Glioma with TRAIL-Secreting Mesenchymal Stem Cells and Lipoxygenase Inhibitor MK886
Authors: Kim Seong Muk , Woo Ji Sun , Jeong Chang Hyun , Ryu Chung Heon , Lim Jung Yeon , Jeun Sin-Soo
Published: April 2023

PDF file - 1.8MB, Upregulation of DR5 after treatment with MK886 in glioma cells
Supplementary Figure 7 from Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary Epithelium
Authors: Brown Nelson E. , Jeselsohn Rinath , Bihani Teeru , Hu Miaofen G. , Foltopoulou Parthena , Kuperwasser Charlotte , Hinds Philip W.
Published: April 2023

PDF file - 103K, Characterization of proliferation in HMECs following knockdown of cyclin D1 or inhibition of Cdk4/6 activity
Supplementary Movie from FRMD4A Upregulation in Human Squamous Cell Carcinoma Promotes Tumor Growth and Metastasis and Is Associated with Poor Prognosis
Authors: Goldie Stephen J. , Mulder Klaas W. , Tan David Wei-Min , Lyons Scott K. , Sims Andrew H. , Watt Fiona M.
Published: April 2023

Quicktime file - 7.8MB, Movies of cell behavior
Supplementary Figure 4 from Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary Epithelium
Authors: Brown Nelson E. , Jeselsohn Rinath , Bihani Teeru , Hu Miaofen G. , Foltopoulou Parthena , Kuperwasser Charlotte , Hinds Philip W.
Published: April 2023

PDF file - 287K, Immortalized KE/Ink4(-) MECs display impaired proliferation and ErbB2/NeuT-mediated transformation
Supplementary Tables 1-6 from Hepatocyte–Stellate Cell Cross-Talk in the Liver Engenders a Permissive Inflammatory Microenvironment That Drives Progression in Hepatocellular Carcinoma
Authors: Coulouarn Cédric , Corlu Anne , Glaise Denise , Guénon Isabelle , Thorgeirsson Snorri S. , Clément Bruno
Published: April 2023

PDF file - 183K
Supplementary Figure 3 from Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary Epithelium
Authors: Brown Nelson E. , Jeselsohn Rinath , Bihani Teeru , Hu Miaofen G. , Foltopoulou Parthena , Kuperwasser Charlotte , Hinds Philip W.
Published: April 2023

PDF file - 233K, Analysis of senescence in mammary glands and tumors
Supplementary Figure Legends 1-5 from Estrogen Promotes ER-Negative Tumor Growth and Angiogenesis through Mobilization of Bone Marrow–Derived Monocytes
Authors: Iyer Vandana , Klebba Ina , McCready Jessica , Arendt Lisa M. , Betancur-Boissel Monica , Wu Meng-Fen , Zhang Xiaomei , Lewis Michael T. , Kuperwasser Charlotte
Published: April 2023

PDF file - 78K
Supplementary Figure 2 from Prohibitin Attenuates Colitis-Associated Tumorigenesis in Mice by Modulating p53 and STAT3 Apoptotic Responses
Authors: Kathiria Arwa S. , Neumann William L. , Rhees Jennifer , Hotchkiss Erin , Cheng Yulan , Genta Robert M. , Meltzer Stephen J. , Souza Rhonda F. , Theiss Arianne L.
Published: April 2023

PDF file - 76K, PHB Tg mice are less susceptible to CAC and mortality
Supplementary Methods, Tables 1-6, Figure Legends 1-4 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma
Authors: Gao Qiang , Zhao Ying-Jun , Wang Xiao-Ying , Qiu Shuang-Jian , Shi Ying-Hong , Sun Jian , Yi Yong , Shi Jie-Yi , Shi Guo-Ming , Ding Zhen-Bin , Xiao Yong-Sheng , Zhao Zhong-Hua , Zhou Jian , He Xiang-Huo , Fan Jia
Published: April 2023

PDF file - 229K
Supplementary Movie 2 from In Vivo Imaging of Drug-Induced Mitochondrial Outer Membrane Permeabilization at Single-Cell Resolution
Authors: Earley Sarah , Vinegoni Claudio , Dunham Joshua , Gorbatov Rostic , Feruglio Paolo Fumene , Weissleder Ralph
Published: April 2023

AVI file, 169KB, Time lapse image sequence of MDA-MB-231 breast cancer cells treated with ABT-263, showing the fluorescent IMS-RP MOMP reporter. The cell with the asterisk undergoes MOMP during this image sequence.
Supplementary Figure 5 from MLK3 Regulates Paxillin Phosphorylation in Chemokine-Mediated Breast Cancer Cell Migration and Invasion to Drive Metastasis
Authors: Chen Jian , Gallo Kathleen A.
Published: April 2023

PDF file - 47K, Maintenance of MLK3 silencing in MDA-MB-231 primary tumors
Supplementary Figure 1 from In Vivo Imaging of Drug-Induced Mitochondrial Outer Membrane Permeabilization at Single-Cell Resolution
Authors: Earley Sarah , Vinegoni Claudio , Dunham Joshua , Gorbatov Rostic , Feruglio Paolo Fumene , Weissleder Ralph
Published: April 2023

PDF file, 394KB, Fig. S1: Colocalization of IMS-RP with full-length Smac/DIABLO and AIF.
Supplementary Figure 1 from Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage
Authors: Fitzgerald Daniel P. , Subramanian Preeti , Deshpande Monika , Graves Christian , Gordon Ira , Qian Yongzhen , Snitkovsky Yeva , Liewehr David J. , Steinberg Seth M. , Paltán-Ortiz José D. , Herman Mary M. , Camphausen Kevin , Palmieri Diane , Becerra S. Patricia , Steeg Patricia S.
Published: April 2023

PDF file - 954K
Supplementary Figure 1 from Global Quantitative Phosphoproteome Analysis of Human Tumor Xenografts Treated with a CD44 Antagonist
Authors: Weigand Stefan , Herting Frank , Maisel Daniela , Nopora Adam , Voss Edgar , Schaab Christoph , Klammer Martin , Tebbe Andreas
Published: April 2023

PDF file - 490K, Overview of regulated phosphoprotein networks after 4.5h anti-CD44 treatment compared to the vehicle control
Supplementary Figure 2 from Alternate Splicing of the p53 Inhibitor HDMX Offers a Superior Prognostic Biomarker than p53 Mutation in Human Cancer
Authors: Lenos Kristiaan , Grawenda Anna M. , Lodder Kirsten , Kuijjer Marieke L. , Teunisse Amina F.A.S. , Repapi Emmanouela , Grochola Lukasz F. , Bartel Frank , Hogendoorn Pancras C.W. , Wuerl Peter , Taubert Helge , Cleton-Jansen Anne-Marie , Bond Gareth L. , Jochemsen Aart G.
Published: April 2023

PDF file - 173K, Analysis of HDMX-S mRNA expression in the NCI60. Cells were examined for HDMX-FL and HDMX-S mRNA expression
Supplementary Legends for Figures 1-4, Tables 1-4 from Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer
Authors: Lee Sangjun , Stewart Sheila , Nagtegaal Iris , Luo Jingqin , Wu Yun , Colditz Graham , Medina Dan , Allred D. Craig
Published: April 2023

PDF file - 74K
Supplementary Figure 1 from Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer
Authors: Lee Sangjun , Stewart Sheila , Nagtegaal Iris , Luo Jingqin , Wu Yun , Colditz Graham , Medina Dan , Allred D. Craig
Published: April 2023

PDF file - 184K, Quantitative realtime polymerase chain reaction (qRT-PCR) was used to confirm the differential expression of selected genes between DCIS and IBC
Supplementary Figure Legends 1-7 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma
Authors: Huang Ping , Rani M.R. Sandhya , Ahluwalia Manmeet S. , Bae Eunnyung , Prayson Richard A. , Weil Robert J. , Nowacki Amy S. , Hedayat Hirad , Sloan Andrew E. , Lathia Justin D. , Rich Jeremy N. , Tipps Russell , Gladson Candece L.
Published: April 2023

PDF file - 79K
Supplementary Figure 2 from Activation of Thermogenesis in Brown Adipose Tissue and Dysregulated Lipid Metabolism Associated with Cancer Cachexia in Mice
Authors: Tsoli Maria , Moore Melissa , Burg Dominic , Painter Arran , Taylor Ryland , Lockie Sarah H. , Turner Nigel , Warren Alessandra , Cooney Greg , Oldfield Brian , Clarke Stephen , Robertson Graham
Published: April 2023

PDF file - 229K, Expression of nuclear transcription factor genes and target genes involved in lipid metabolism
Supplementary Figure 4 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma
Authors: Huang Ping , Rani M.R. Sandhya , Ahluwalia Manmeet S. , Bae Eunnyung , Prayson Richard A. , Weil Robert J. , Nowacki Amy S. , Hedayat Hirad , Sloan Andrew E. , Lathia Justin D. , Rich Jeremy N. , Tipps Russell , Gladson Candece L.
Published: April 2023

PDF file - 658K, Characterization of the integrin receptors mediating the attachment of primary brain ECs to collagen, fibronectin and laminin.
Supplementary Materials and Methods from Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET
Authors: Xu Lu , Kikuchi Eiki , Xu Chunxiao , Ebi Hiromichi , Ercan Dalia , Cheng Katherine A. , Padera Robert , Engelman Jeffrey A. , Jänne Pasi A. , Shapiro Geoffrey I. , Shimamura Takeshi , Wong Kwok-Kin
Published: April 2023

PDF file - 329K, Procedures for xenografts and a list of antibodies used for IHC and Western blots
Supplementary Figure Legends 1-6 from Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET
Authors: Xu Lu , Kikuchi Eiki , Xu Chunxiao , Ebi Hiromichi , Ercan Dalia , Cheng Katherine A. , Padera Robert , Engelman Jeffrey A. , Jänne Pasi A. , Shapiro Geoffrey I. , Shimamura Takeshi , Wong Kwok-Kin
Published: April 2023

PDF file - 99K
Supplementary Figures 1-3 from Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment
Authors: Lesokhin Alexander M. , Hohl Tobias M. , Kitano Shigehisa , Cortez Czrina , Hirschhorn-Cymerman Daniel , Avogadri Francesca , Rizzuto Gabrielle A. , Lazarus John J. , Pamer Eric G. , Houghton Alan N. , Merghoub Taha , Wolchok Jedd D.
Published: April 2023

PDF file - 1.8MB
Supplementary Figure 1 from TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression
Authors: Duvvuri Umamaheswar , Shiwarski Daniel J. , Xiao Dong , Bertrand Carol , Huang Xin , Edinger Robert S. , Rock Jason R. , Harfe Brian D. , Henson Brian J. , Kunzelmann Karl , Schreiber Rainer , Seethala Raja S. , Egloff Ann Marie , Chen Xing , Lui Vivian W. , Grandis Jennifer R. , Gollin Susanne M.
Published: April 2023

PDF file - 139K, Anti-TMEM16A antibody recognizes endogeneous TMEM16A in immunohistochemistry. A rabbit polyclonal antibody was raised against a human TMEM16A epitope (as described in the Materials and Methods). This antibody was validated in immunohistochemistry using tissues obtained from Tmem16a -/- mice and wild-type littermates. Gastrointestinal stromal tumor (a tumor type that is known to overexpress TMEM16A) is used a positive control. The in-house antibody was compared against a commercial rabbit monoclonal DOG1 antibody (Thermo Fisher Scientific, Rockford, IL) which is a validated antibody that is used by our clinical Pathology laboratory for IHC (A). Surface biotinylation was used to demonstrate that TMEM16A is present on the cell membrane of T24 cells, and migrates at the expected molecular weight (~115kDa). Murine Tmem16a migrates at a higher molecular weight (~150 kDa), in accordance with previously published data (B).
Supplementary Table 2 from Mammalian Sterile 20–like Kinase 1 Suppresses Lymphoma Development by Promoting Faithful Chromosome Segregation
Authors: Kim Tae-Shin , Lee Da-Hye , Kim Sang Kyum , Shin So Youn , Seo Eul-Ju , Lim Dae-Sik
Published: April 2023

PDF file - 19K, Characteristics of moribund p53-/-Mst1+/+ and p53-/-Mst1-/- mice
Supplementary Table 1 from Mammalian Sterile 20–like Kinase 1 Suppresses Lymphoma Development by Promoting Faithful Chromosome Segregation
Authors: Kim Tae-Shin , Lee Da-Hye , Kim Sang Kyum , Shin So Youn , Seo Eul-Ju , Lim Dae-Sik
Published: April 2023

PDF file - 19K, Characteristics of ENU-treated moribund mice
Supplementary Tables 1-2, Figures 1-7 from Extracellular Matrix Protein CCN1 Limits Oncolytic Efficacy in Glioma
Authors: Haseley Amy , Boone Sean , Wojton Jeffrey , Yu Lianbo , Yoo Ji Young , Yu Jianhua , Kurozumi Kazuhiko , Glorioso Joseph C. , Caligiuri Michael A. , Kaur Balveen
Published: April 2023

PDF file - 441K
Supplementary Figure 1 from RANK Induces Epithelial–Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis
Authors: Palafox Marta , Ferrer Irene , Pellegrini Pasquale , Vila Sergi , Hernandez-Ortega Sara , Urruticoechea Ander , Climent Fina , Soler Maria Teresa , Muñoz Purificación , Viñals Francesc , Tometsko Mark , Branstetter Dan , Dougall William C. , González-Suárez Eva
Published: April 2023

PDF file - 91K, RANK is expressed and active in MCF10A cells
Supplementary Table 1 from Frequent PVT1 Rearrangement and Novel Chimeric Genes PVT1-NBEA and PVT1-WWOX Occur in Multiple Myeloma with 8q24 Abnormality
Authors: Nagoshi Hisao , Taki Tomohiko , Hanamura Ichiro , Nitta Masakazu , Otsuki Takemi , Nishida Kazuhiro , Okuda Keiko , Sakamoto Natsumi , Kobayashi Satoru , Yamamoto-Sugitani Mio , Tsutsumi Yasuhiko , Kobayashi Tsutomu , Matsumoto Yosuke , Horiike Shigeo , Kuroda Junya , Taniwaki Masafumi
Published: April 2023

PDF file - 122K, Findings of interphase FISH signal patterns
Supplementary Figure 3 from Stromal Progenitor Cells from Endogenous Adipose Tissue Contribute to Pericytes and Adipocytes That Populate the Tumor Microenvironment
Authors: Zhang Yan , Daquinag Alexes C. , Amaya-Manzanares Felipe , Sirin Olga , Tseng Chieh , Kolonin Mikhail G.
Published: April 2023

PDF file - 2.2MB, Identification of ASC among mouse PBMC leukocytes
Supplementary Figure 5 from A Positive Feedback Signaling Loop between ATM and the Vitamin D Receptor Is Critical for Cancer Chemoprevention by Vitamin D
Authors: Ting Huei-Ju , Yasmin-Karim Sayeda , Yan Shian-Jang , Hsu Jong-Wei , Lin Tzu-Hua , Zeng Weisi , Messing James , Sheu Tzong-Jeng , Bao Bo-Ying , Li Willis X. , Messing Edward , Lee Yi-Fen
Published: April 2023

PDF file - 275K
Supplementary Figures 1-7 from High-Throughput RNAi Screening Reveals Novel Regulators of Telomerase
Authors: Cerone Maria Antonietta , Burgess Darren J , Naceur-Lombardelli Cristina , Lord Christopher J. , Ashworth Alan
Published: April 2023

Supplementary Figures 1-7 from High-Throughput RNAi Screening Reveals Novel Regulators of Telomerase
Supplementary Figure Legends 1-7 from High-Throughput RNAi Screening Reveals Novel Regulators of Telomerase
Authors: Cerone Maria Antonietta , Burgess Darren J , Naceur-Lombardelli Cristina , Lord Christopher J. , Ashworth Alan
Published: April 2023

Supplementary Figure Legends 1-7 from High-Throughput RNAi Screening Reveals Novel Regulators of Telomerase
Supplementary Figure 3 from CD44s Regulates the TGF-β–Mediated Mesenchymal Phenotype and Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
Authors: Mima Kosuke , Okabe Hirohisa , Ishimoto Takatsugu , Hayashi Hiromitsu , Nakagawa Shigeki , Kuroki Hideyuki , Watanabe Masayuki , Beppu Toru , Tamada Mayumi , Nagano Osamu , Saya Hideyuki , Baba Hideo
Published: April 2023

PDF file - 2.6MB, TGF-beta signaling triggered the mesenchymal phenotype and induced the expression of CD44s in HCC cells
Supplementary Figure 1 from Metastatic Progression with Resistance to Aromatase Inhibitors Is Driven by the Steroid Receptor Coactivator SRC-1
Authors: McBryan Jean , Theissen Sarah M. , Byrne Christopher , Hughes Eamon , Cocchiglia Sinead , Sande Stephen , O'Hara Jane , Tibbitts Paul , Hill Arnold D.K. , Young Leonie S.
Published: April 2023

PDF file - 175K
Supplementary Figure 1 from CD44s Regulates the TGF-β–Mediated Mesenchymal Phenotype and Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
Authors: Mima Kosuke , Okabe Hirohisa , Ishimoto Takatsugu , Hayashi Hiromitsu , Nakagawa Shigeki , Kuroki Hideyuki , Watanabe Masayuki , Beppu Toru , Tamada Mayumi , Nagano Osamu , Saya Hideyuki , Baba Hideo
Published: April 2023

PDF file - 2.2MB, The expression profile of cancer stem cells markers in five HCC cell lines
Supplementary Table 3 from Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma
Authors: Dougherty Joseph D. , Fomchenko Elena I. , Akuffo Afua A. , Schmidt Eric , Helmy Karim Y. , Bazzoli Elena , Brennan Cameron W. , Holland Eric C. , Milosevic Ana
Published: April 2023

XLS file - 43K, Summary of all information for DorQ candidates Fold Change: Average fold of normal Olig2 cells vs all tumor samples. P-value: associated limma p-value with and without FDR. Allen ISH: Scoring on Allen Brain Atlas in situ hybridization patterns for a pattern consistent with expression in OPCs. S: Specific, E: Expressed in these cells and others, A: Absent, U: No signal (unscorable), N: Clearly not in OPCs. *Ttr has a pattern suggestive of choroid plexus, consistent with PDGFRA expression in choroid. Ratio Del/Dups - is the ratio of the number of human glioma samples with a deletion to those with duplications, as counted by RAE algorithm (N=216). % of tumors showing a deletion
Supplementary Figure 2 from Expression of P2X7 Receptor Increases In Vivo Tumor Growth
Authors: Adinolfi Elena , Raffaghello Lizzia , Giuliani Anna Lisa , Cavazzini Luigi , Capece Marina , Chiozzi Paola , Bianchi Giovanna , Kroemer Guido , Pistoia Vito , Di Virgilio Francesco
Published: April 2023

PDF file, 88KB, Fig. S2. Effect of P2X7 expression on the growth of CT26 colon carcinoma. Panel A, detection of mP2X7 by semiquantitative PCR and Western blot in CT26-wt cells and in three stably transfected clones (CT26-mP2X7c1, c2, and c3). G3PDH and actin are shown as housekeeping control gene and protein, respectively. Panel B, representative sizes of tumor masses excised at d 15 post-inoculum. Panel C, average � SE volumes of excised tumor masses; green, CT26wt (n=10); black, CT26-mP2X7c1( n=10) ; red, CT26-mP2X7c2 (n=10); blue, CT26-mP2X7c3 (n=10). * p <0.05 versus CT26-wt.
Supplementary Figure 3 from Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma
Authors: Dougherty Joseph D. , Fomchenko Elena I. , Akuffo Afua A. , Schmidt Eric , Helmy Karim Y. , Bazzoli Elena , Brennan Cameron W. , Holland Eric C. , Milosevic Ana
Published: April 2023

PDF file - 391K, Gene Ontology analysis reveals that RNAs specific to OPCs (such as in black box, from Figure 2E), are highly enriched in messages related to cell cycle, as expected, as well as in genes involved in biopolymer modification
Supplementary Figure 2 from Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma
Authors: Dougherty Joseph D. , Fomchenko Elena I. , Akuffo Afua A. , Schmidt Eric , Helmy Karim Y. , Bazzoli Elena , Brennan Cameron W. , Holland Eric C. , Milosevic Ana
Published: April 2023

PDF file - 1MB, Gene Ontology analysis reveals Biological Process categories enriched for A) Neuron, B) Astrocyte, and C) Mature Oligodendrocyte gene lists
Supplementary Figure 1 from Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma
Authors: Dougherty Joseph D. , Fomchenko Elena I. , Akuffo Afua A. , Schmidt Eric , Helmy Karim Y. , Bazzoli Elena , Brennan Cameron W. , Holland Eric C. , Milosevic Ana
Published: April 2023

PDF file - 1.1MB, Histological and immunocytochemical characterization of the RACS-PDGFb-induced tumors in Ntv-a-Olig2-bacTRAP mice resemble human grade IV malignant glioblastoma. A-A1: Low magnification image of the hematoxylin and eosin stained cryostat section of the large, high grade tumor excised from the Ntv-a/ink4a/arf+/- Olig2::EgfpL10a mouse. Higher magnification of the boxed area in A shows similarities with the human GBM, including pseudopalisades (arrows), surrounding areas of necrosis (asterisk), and vascular proliferation (arrowheads). B: Large number of Olig2-positive cells in the PDGF-B-induced glioblastoma on the Ntv-a/ink4a/arf+/- Olig2: EgfpL10a background are labeled with the antibody against proliferation marker Ki67, confirming high proliferative index of tumor cells
Supplementary Figure 6 from Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter
Authors: Basseville Agnes , Tamaki Akina , Ierano Caterina , Trostel Shana , Ward Yvona , Robey Robert W. , Hegde Ramanujan S. , Bates Susan E.
Published: April 2023

PDF file - 26K, Chaperone expression after HDI treatment
Supplementary Figure 5 from Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter
Authors: Basseville Agnes , Tamaki Akina , Ierano Caterina , Trostel Shana , Ward Yvona , Robey Robert W. , Hegde Ramanujan S. , Bates Susan E.
Published: April 2023

PDF file - 29K, Impact of CHX and actinomycin D on HDI-induced ABCG2 surface overexpression
Supplementary Figure 4 from Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter
Authors: Basseville Agnes , Tamaki Akina , Ierano Caterina , Trostel Shana , Ward Yvona , Robey Robert W. , Hegde Ramanujan S. , Bates Susan E.
Published: April 2023

PDF file - 26K, CHX does not affect histone and �-tubulin acetylation induced by HDIs
Supplementary Materials and Methods from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma
Authors: Jube Sandro , Rivera Zeyana S. , Bianchi Marco E. , Powers Amy , Wang Ena , Pagano Ian , Pass Harvey I. , Gaudino Giovanni , Carbone Michele , Yang Haining
Published: April 2023

PDF file - 106K
Supplementary Figure 3 from Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter
Authors: Basseville Agnes , Tamaki Akina , Ierano Caterina , Trostel Shana , Ward Yvona , Robey Robert W. , Hegde Ramanujan S. , Bates Susan E.
Published: April 2023

PDF file - 43K, HDIs do not induce endogenous ABCG2 expression in Flip-In-293 cells