bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptome Analysis of Drought Stress and Rehydration in the Trachycarpus fortunei Seedling Stage
Authors: Feng Xiao , Yang Zhao , Xiu-Rong Wang
Published: February 2020

Background: Trachycarpus fortunei has broad economic benefits and excellent drought resistance; however, its drought response, adaptation, and recovery processes remain unclear. In this study, the response, tolerance, and recovery processes of T. fortunei leaves and roots under drought stress were determined by Illumina sequencing.Results: Under drought stress, T. fortunei reduced its light-capturing ability and composition of its photosynthetic apparatus, thereby reducing photosynthesis to prevent photo-induced chloroplast reactive oxygen damage during dehydration. The phenylpropanoid biosynthesis process in the roots was contained and ABA induced the accumulation of intracellular osmoprotectants, as well as DHNs, LEA, Annexin D2, NAC, and other genes, which may play important roles in protecting the cell membrane’s permeability in T. fortunei root tissues. During the rehydration phase, fatty acid biosynthesis in T. fortunei roots was repressed. Weighted correlation network analysis (WGCNA) screened modules that were positively or negatively correlated with physiological traits. The Real-time quantitative PCR (RT-qPCR) results indicated the reliability of the transcriptomic data. Conclusions: These findings provide valuable information for identifying important components in the T. fortunei drought signaling network and enhances our understanding of the molecular mechanisms by which T. fortunei responds to drought stress.
WITHDRAWN: Identification of death-associated protein-like 1 (DAPL1) as a novel prognostic biomarker of breast cancer
Authors: Zhang Haichao , Qu Xin , Han Lu
Published: February 2020

Background: It is meaningful to identify the potential clinical prognosis-associated oncogenes for cases with breast cancer, considering the complicated pathogenesis of breast cancer.Methods: We first utilized the bioinformatics approach to investigate the role of the DAPL1 (death-associated protein-like 1) in breast cancer, based on the available datasets of TCGA and GEO.Results: DAPL1 is lowly expressed in breast cancer tissues compared with the normal tissues. For the breast cancer cases of the TCGA-BRCA cohort, we observed a correlation between lowly expressed DAPL1 gene and poor clinical prognosis of overall survival ( P =0.0028). Based on the survival data of GEO, the low DAPL1 expression was associated with a poor prognosis of distant metastasis free survival ( P =0.0023), and relapse free survival ( P =0.0065). DAPL1 expression was linked to the mutation status or copy number variation o f several genes, such as MAP3K1 , NUP98 , and CCDC59. The infiltration level of immune cells (e.g., M1 macrophage, Follicular B helper T cells, etc.) may be involved in the etiology of breast cancer. Based on the DAPL1 -correlated genes, GSEA, GO, and KEGG analysis data indicated the association between DAPL1 expression and a series of biological issues, such as DNA packaging complex, DNA repair complex, nucleotide excision repair, ubiquitin-like protein binding, and ubiquitin proteasome pathway. We also identified several DAPL1 -associated phosphorylation kinases, such as MAPK, PRKACA, and GSK3B.Conclusions: DAPL1 gene is first identified as a prognosis biomarker of breast cancer, and the underlying molecular mechanism involves protein phosphorylation, immune cell infiltration, and DNA repair or protein ubiquitin-associated cellular pathways.
SERS imaging elucidates the folate receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs-induced cell apoptosis
Authors: Tang Ping , Xing Meishuang , Tao Qiao , Chen Wendai , Xing Xinyue , Liu Shengde , Lu Xiaoxu , Zhong Liyun
Published: February 2020

Background: Chemotherapy and radiotherapy are common methods of cancer treatment, but they are accompanied by serious side effects. Actually, many cancer cells have overexpression of folic acid (FA) receptor and by FA receptor-mediated endocytosis, anticancer drugs can be easily internalized into cancer cell, this will greatly improve the curative effect and decrease side effects. Along with the development of nanotechnology, phototherapy, owning advantages in tissue selectivity, process controlling, low toxicity and reproducible treatment, has become very promising, especially for photothermal therapy (PTT) and photodynamic therapy (PDT). Since both PTT and PDT involve the utilization of light energy, so they synergistic treatment should be a good solution by ingenious design. In this paper, based on surface enhanced Raman spectroscopy (SERS) imaging, we hope to construct a FA receptor-mediated PTT/PDT synergistic anticancer nanodrug (nanoprobe), and achieve the intracellular distribution information of the nanodrugs during cell apoptosis, and then elucidate PTT/PDT-induced cell apoptosis and synergistic efficiency.Results: FA receptor-mediated PTT/PDT synergistic anticancer nanodrugs with tracing function are prepared by the chemical synthesis and modification of gold nanorods (GNR), involving protoporphyrin IX (PpIX), 4-mecaptobenzoic acid (MBA), and FA. Based on SERS imaging, it is found that the FA receptor-mediated endocytosis can greatly facilitate the nanodrugs internalization, in which both the number and intracellular dispersion of the PpIX-GNR-MBA-FA nanodrugs are improved relative to the GNR-MBA or PpIX-GNR-MBA compositions, and then enhance the PTT/PDT-induced cell apoptosis.Conclusion: SERS imaging is very suitable for the phototherapy tracing due to its high sensitivity and stability. The FA receptor-mediated way can significantly facilitate nanodrugs internalization, PTT/PDT-induced cell apoptosis and synergistic efficiency. Importantly, this FA receptor-mediated SERS imaging based PTT/PDT synergistic treatment will provide a novel strategy for the design and application of anticancer phototherapy nanodrugs.
Analyses of DNA methylation involved in the activation of nuclear karyopherin alpha 2 leading to the progression and prognostic significance across human breast cancer
Authors: Cui Xiangrong , Liang Hongping , Hao Chonghua , Huo Kai , Jing Xuan
Published: February 2020

Background: Karyopherin alpha 2 (KPNA2) is a nuclear import factor that plays a crucial role in nucleocytoplasmic transport, as well as cell proliferation, migration and invasion in several cancers. However, the roles of KPNA2 in breast cancer as well as the underlying molecular mechanisms have not been elucidated. Methods: To evaluate gene expression alterations during breast carcinogenesis, KPNA2 expression was analyzed using the Gene Expression Profiling Interactive Analysis and Oncomine analyses. The correlation between methylation and expression was analyzed using the MEXPRESS tool, UALCAN cancer database, and cBioPortal browser. Then, the expression and prognostic value of KPNA2 was investigated by our own breast cancer samples using RT-PCR. KPNA2 methylation level was detected by methylation-specific PCR. Results: We obtained the following important results. (1) KPNA2 expression was significantly higher in breast cancer than normal samples and regulated by aberrant DNA hypomethylation of promoter region. (2) Among patients with breast cancer, those with higher KPNA2 expression had a lower survival rate. (3) The major mutation type of KPNA2 in breast cancer samples was missense mutation. (4) Homer1 was able to promote breast cancer progression may be through up-regulating TPX2 expression. Conclusions: Our findings suggest that aberrant DNA hypomethylation of promoter regions contributes to the aberrant expression of KPNA2 in breast cancer, which might be a potential indicator of poor prognosis.
Melatonin affects hypoxia-inducible factor 1α and ameliorates delayed brain injury following subarachnoid hemorrhage via H19/miR-675/HIF1A/TLR4
Authors: Xia Da-yong , Jiang Xiao-chun , Li Zhen-bao , Dai Yi , Zhang Zi-huan , Yang Song
Published: February 2020

Background: This study was aimed to investigate the molecular mechanism of how melatonin interferes with hypoxia-inducible factor 1α (HIF1A) and TLR4 expression, which is implicated in the management of delayed brain injury (DBI) after subarachnoid hemorrhage (SAH). Method: Luciferase assay, real-time PCR, Western-blot analysis and immunohistochemistry (IHC) assays were utilized to explore the interaction among H19, miR-675, HIF1A and TLR4, and to evaluate the effect of MT on the expression of above transcripts in different groups. Results: MT enhanced H19 expression by promoting the transcription efficiency of H19 promoter, and HIF1A was identified as a target of miR-675. HIF1A enhanced TLR4 expression via promoting the transcription efficiency of TLR4 promoter. Furthermore, administration of MT up-regulated miR-675 but suppressed the expressions of HIF1A and TLR4. Treatment with MT alleviated neurobehavioral deficits and apoptosis induced by SAH. According to the result of IHC, HIF1A and TLR4 protein levels in the SAH group were much higher than those in the SAH+MT group. Therefore, the administration of MT increased the levels of H19 and miR-675 which have been inhibited by SAH. In a similar way, treatment with MT decreased the levels of HIF1A and TLR4 which have been enhanced by SAH. Conclusion: MT could down-regulate the expression of HIF1A and TLR4 via the H19/miR-675/HIF1A/TLR4 signaling pathway, while TLR4 is crucial to the release of pro-inflammatory cytokines. Therefore, the treatment with MT could ameliorate post-SAH DBI.
WITHDRAWN: Silent information regulator 1 ameliorates oxidative stress injury via PGC-1α/PPARγ-Nrf2 pathway after ischemic stroke in rat.
Authors: zhou yang , Peng Li , Jiang Ning , Wu Jingxian , Li Yixin , Yu Shanshan , zhao yong
Published: February 2020

Background Astrocytes mediate brain defense against oxidative stress-induced injury. Silent information regulator 1 (SIRT1) has anti-oxidative stress effects in many diseases and is highly expressed in astrocytes. However, the neuroprotective effects of SIRT1 on astrocytes after cerebral ischemia/reperfusion injury are unclear. Methods Here, we evaluated the effects of SIRT1 in astrocytes after cerebral ischemia/reperfusion injury using oxygen-glucose deprivation/recovery in astrocytes in vitro and middle cerebral artery occlusion in rats in vivo. Results SIRT1 knockdown reduced cell viability, increased oxidative stress, and decreased peroxisome proliferator activated receptor (PPAR)-γ coactivator (PGC)-1α, PPARγ, nuclear factor erythroid 2-related factor 2 (NRF2), heme oxygenase (HO)-1, and NAD(P)H:quinone oxidoreductase-1 (NQO1) expression. Moreover, SIRT1 knockdown also suppressed PGC-1α activity, the PGC-1α/PPARγ interaction, and the PPARγ/peroxisome proliferator-response element (PPRE) interaction. Similarly, in our in vivo experiments, SIRT1 overexpression and PGC-1α or PPARγ knockdown reduced PGC-1α, PPARγ, NRF2, HO-1, and NQO1 protein expression and blocked the PGC-1α/PPARγ interaction. SIRT1 overexpression plus PPARγ knockdown inhibited the interaction of PPARγ with PPRE. NRF2 knockdown blocked NRF2 expression and downstream proteins induced by SIRT1 overexpression. Conclusion Overall, our data indicated that SIRT1 directly mediated the PGC-1α/PPARγ pathway in response to focal cerebral ischemia/reperfusion-induced neurological deficit, providing insights into the treatment of focal cerebral ischemia/reperfusion injury.
Efficacy and safety of wait and see strategy versus surgery for rectal cancer with cCR/near-cCR response after neoadjuvant chemoradiotherapy: a meta-analysis
Authors: Zhao Guo-hua , Deng Li , Ye Dong-man , Wang Wen-hui , Yan Yan , yu tao
Published: February 2020

Background To evaluate the efficacy and safety between wait and see strategy (WS) and surgery of rectal cancer patients with cCR/near-cCR response after neoadjuvant chemoradiotherapy. Methods We searched PubMed, Cochrane Library, CNKI(China National Knowledge Infrastructure) and Wanfang databases to compare wait and see strategy with surgery for rectal cancer with cCR/near-cCR response after neoadjuvant chemoradiotherapy up to January 2020. We collected the data of local recurrence, distant metastasis, cancer related death, overall survival and diseasr-free survival and compared the advantages and disadvantages of the two groups. Results 14 English studies with 3932 patients were included. There were 700 patients in WS group and 3232 patients in surgical group. WS group had higher local recurrence rate than surgery group(OR:3.55, 95% CI:2.35 to 5.36, P <0.001). WS group had better 2-year DFS(OR:0.74, 95% CI:0.56 to 0.96, P =0.03) and 2-year OS (OR:0.38, 95% CI:0.28 to 0.52, P <0.001) than surgery group. Subgroup analysis of WS group and radical surgery group also obtained the similar results. Eastern studies also supported the conclusion. There was no significant difference of other data between the two groups. Conclusion Compared with surgery group, WS group would increase the risk of local recurrence rate, but WS group had better 2-year DFS and OS than surgery group. However, WS group did not increase the possibility of distant metastasis and cancer related death of the patients.
Ca alleviated Cd-induced toxicity in Salix matsudana by affecting Cd absorption, translocation, subcellular distribution, and chemical forms
Authors: Shang Xiaoshuo , Xue Wenxiu , Jiang Yi , Zou Jinhua
Published: February 2020

Background: Cadmium (Cd), a ubiquitous and highly toxic heavy metal pollutant, is toxic to animals and plants. Calcium (Ca) is an essential component for plant growth and reduces plant Cd adsorption by competing with Cd. To gain deeper insight into the effects of Ca on Cd absorption, translocation, subcellular distribution, and chemical forms in S. matsudana seedlings under Cd stress, an investigation was conducted on these properties. Results: Adding Ca alleviated Cd physiological toxicity in S. matsudana, reduced Cd adsorption, increased the translocation from roots to shoots, lead to subcellular redistribution of Cd by increasing the proportion of Cd in soluble fractions but decreasing Cd in the cell wall and changed the chemical forms of Cd from 0.6 M HCl- and 2% HAc-extracted Cd to 1 M NaCl-extracted Cd. The energy dispersive X-ray analyses (EDXA) results revealed that after adding Ca, Cd was transferred through the root epidermis, cortex, endodermis, and vascular cylinder, transported to the shoots, and was highly accumulated in leaf epidermal and mesophyll cells, but less in leaf vein and guard cells. The genes involved in Cd uptake and xylem loading included NRAMP1, ZIP8, HMA2, and HMA4, which were up-regulated significantly (p < 0.05) in the Cd and Cd + Ca treatments compared to the control. Conclusions: The findings of this study provide new insight into the mechanism that Ca alleviates Cd toxicity in woody tree species, as well as propose an important prospect of Ca addition for improving the phytoremediation of Cd contamination.
Properties of heavy mesons at finite temperature
Authors: Montaña Gloria , Ramos Angels , Tolós Laura
Published: February 2020

We study the properties of heavy mesons using a unitarized approach
in a hot pionic medium, based on an effective hadronic theory. The
interaction between the heavy mesons and pseudoscalar Goldstone bosons
is described by a chiral Lagrangian at next-to-leading order in the
chiral expansion and leading order in the heavy-quark mass expansion so
as to satisfy heavy-quark spin symmetry. The meson-meson scattering
problem in coupled channels with finite-temperature corrections is
solved in a self-consistent manner. Our results show that the masses of
the ground-state charmed mesons D(0^-)D(0−)
and D_s(1^-)Ds(1−)
decrease in a pionic environment at T\neq 0T≠0
and they acquire a substantial width. As a consequence, the behaviour of
excited mesonic states (D_{s0}^*(2317)^\pmDs0*(2317)±
and D_0^*(2300)^{0,\pm}D0*(2300)0,±),
generated dynamically in our heavy-light molecular model, is also
modified at T\neq 0T≠0.
The aim is to test our results against Lattice QCD calculations in the
future.
Xanthan-based biodegradable packaging for fish and meat products
Authors: Giro Tatiana , Beloglazova Kristina , Rysmukhambetova Gulsara , Simakova Inna , Karpunina Lidiya , Rogojin Anton , Kulikovsky Andrey , Andreeva Svetlana
Published: February 2020

Nowadays, the development of environmentally-friendly packaging materials is relevant worldwide. Biodegradable packaging materials are promising due to their safety and ability to extend shelf life of food products. This study aimed to investigate the properties of biodegradable film based on a bacterial exopolysaccharide (xanthan) with the view to extend the quality and shelf life of chilled meat products. We studied pork and carp samples packed in biodegradable film and stored at 0–2°C. Biodegradable packaging had positive effects on sensory, physicochemical, and microbiological parameters, as well as on ecological safety of the raw materials. During storage of packed chilled pork, its mass loss decreased from 2.16 to 0.21% (norm to 0.30%), and water activity reduced from 0.985 to 0.960, which had a positive effect on the microbiological resistance of pork during storage. The use of biodegradable film contributed to the preservation of quality and freshness of carp, which was confirmed by sensory and microbiological indicators. Total microbial contamination in carp packed in biodegradable film was significantly lower than that in unpacked samples, which extended its shelf life for one day compared to control. Biodegradable packaging also allowed mass loss and pH value to decrease during storage and inhibited oxidation processes in the samples under study. Free fatty acid content decreased by a factor of two, and peroxides, by 7%. Thus, biodegradable films can be effective film coatings to use in the food industry. This method of packaging not only preserves the functional and technological properties of food products, lowers their mass loss, and extends their shelf life, but also reduces costs and is environmentally friendly.
Evaluating the performance of a simple phenomenological model for online forecasting of ammonium concentrations at WWTP inlets
Authors: Vezzaro Luca , Pedersen Jonas Wied , Larsen Laura Holm , Thirsing Carsten , Duus Lene Bassø , Mikkelsen Peter Steen
Published: February 2020

A simple model for online forecasting of ammonium (NH4+) concentrations in sewer systems is proposed. The forecast model utilizes a simple representation of daily NH4+ profiles and the dilution approach combined with information from online NH4+ and flow sensors. The method utilizes an ensemble approach based on past observations to create model prediction bounds. The forecast model was tested against observations collected at the inlet of two wastewater treatment plants (WWTPs) over an 11-month period. NH4+ data were collected with ion-selective sensors. The model performance evaluation focused on applications in relation to online control strategies. The results of the monitoring campaigns highlighted a high variability in daily NH4+ profiles, stressing the importance of an uncertainty-based modelling approach. The maintenance of the NH4+ sensors resulted in important variations of the sensor signal, affecting the evaluation of the model structure and its performance. The forecast model succeeded in providing outputs that potentially can be used for integrated control of wastewater systems. This study provides insights on full scale application of online water quality forecasting models in sewer systems. It also highlights several research gaps which – if further investigated – can lead to better forecasts and more effective real-time operations of sewer and WWTP systems.
Decoding Protein-protein Interactions: An Overview
Authors: Slater Olivia , Miller Bethany , Kontoyianni Maria
Published: February 2020

Drug discovery has focused on the paradigm “one drug, one target” for a long time. However, small molecules can act at multiple macromolecular targets, which serves as the basis for drug repurposing. In an effort to expand the target space, and given advances in X-ray crystallography, protein-protein interactions have become an emerging focus area of drug discovery enterprises. Proteins interact with other biomolecules and it is this intricate network of interactions that determines the behavior of the system and its biological processes. In this review, we briefly discuss networks in disease, followed by computational methods for protein-protein complex prediction. Computational methodologies and techniques employed towards objectives such as protein-protein docking, protein-protein interactions, and interface predictions are described extensively. Docking aims at producing a complex between proteins, while interface predictions identify a subset of residues on one protein that could interact with a partner, and protein-protein interaction sites address whether two proteins interact. In addition, approaches to predict hot spots and binding sites are presented along with a representative example of our internal project on the chemokine CXC receptor 3 B-isoform and predictive modeling with IP10 and PF4.
The Molecular Docking of Flavonoids Isolated from Daucus carota as a Dual Inhibitor of MDM2 and MDMX
Authors: Muhammad Ijaz , Rahman Noor , Nayab Gul E. , Niaz Sadaf , Shah Mohibullah , Afridi Sahib G. , Khan Haroon , Daglia Maria , Capanoglu Esra
Published: February 2020

Background:

Cancer is characterized by overexpression of p53 associated proteins, which
down-regulate P53 signaling pathway. In cancer therapy, p53 activity can be restored by inhibiting the
interaction of MDMX (2N0W) and MDM2 (4JGR) proteins with P53 protein.

Objective:

In the current, study in silico approaches were adapted to use a natural product as a source
of cancer therapy.

Methods:

In the current study in silico approaches were adapted to use a natural product as a source of
cancer therapy. For in silico studies, Chemdraw and Molecular Operating Environment were used for
structure drawing and molecular docking, respectively. Flavonoids isolated from D. carota were
docked with cancerous proteins.

Result:

Based on the docking score analysis, we found that compound 7 was the potent inhibitor of
both cancerous proteins and can be used as a potent molecule for inhibition of 2N0W and 4JGR interaction
with p53.

Conclusion:

Thus the compound 7 can be used for the revival of p53 signaling pathway function however,
intensive in vitro and in vivo experiments are required to prove the in silico analysis.
The Cardiac Conduction and Contractility Complications of Methamphetamine Use and the Relationship to Psychiatric Comorbidity: A Systematic Review
Authors: Baker Sarah , Castle David
Published: February 2020

Background:

Methamphetamine has the potential to produce more severe short and long
term effects than typical amphetamines due to the drug’s increased purity. The cardiovascular consequences
compromise a large proportion of the drug’s mortality. Previous reviews have not examined
these complications in relation to psychiatric patients who have high rates of substance use and
physical comorbidity.

Methods:

Ovid Medline, Embase, Emcare, PsycINFO, CINAHL, and Cochrane were systematically
searched in English until November 2017. Data were coded according to study design, sample size,
demographics, medical and psychiatric comorbidity, electrocardiograph abnormalities, echocardiograph
parameters, illness severity, treatment, and outcome on follow up.

Results:

The 11 included studies were predominantly case series conducted in the USA. Males were
more likely to use methamphetamine and be associated with global systolic dysfunction. The mean
age was lower for those with methamphetamine-related cardiovascular complications. QTc interval
prolongation was the most frequent electrocardiograph abnormality. Continued methamphetamine
use was associated with persistently impaired ventricular function, whilst discontinuation led to
remodeling and improved ejection fraction. Only one study referenced psychiatric comorbidity or
dual diagnosis.

Conclusion:

This review describes the range of variables related to methamphetamine associated
arrhythmias and cardiomyopathies. Early detection of methamphetamine use and the subsequent
cardiac complications is important, especially in a psychiatric cohort where physical illness is more
commonly neglected. The monitoring of electrocardiographs in methamphetamine users is also
crucial. Future research is needed to allow for appropriate recommendations in managing the harmful
impacts of methamphetamine use in this population.
Using Blockchain Technology to Mitigate Challenges in Service Access for the Homeless and Data Exchange Between Providers: Qualitative Study
Authors: Khurshid Anjum , Rajeswaren Vivian , Andrews Steven
Published: February 2020

Background

In the homeless population, barriers to housing and supportive services include a lack of control or access to data. Disparate data formats and storage across multiple organizations hinder up-to-date intersystem access to records and a unified view of an individual’s health and documentation history. The utility of blockchain to solve interoperability in health care is supported in recent literature, but the technology has yet to be tested in real-life conditions encompassing the complex regulatory standards in the health sector.

Objective

This study aimed to test the feasibility and performance of a blockchain system in a homeless community to securely store and share data across a system of providers in the health care ecosystem.

Methods

We performed a series of platform demonstrations and open-ended qualitative feedback interviews to determine the key needs and barriers to user and stakeholder adoption. Account creation and data transactions promoting organizational efficiency and improved health outcomes in this population were tested with homeless users and service providers.

Results

Persons experiencing homelessness and care organizations could successfully create accounts, grant and revoke data sharing permissions, and transmit documents across a distributed network of providers. However, there were issues regarding the security of shared data, user experience and adoption, and organizational preparedness for service providers as end users. We tested a set of assumptions related to these problems within the project time frame and contractual obligations with an existing blockchain-based platform.

Conclusions

Blockchain technology provides decentralized data sharing, validation, immutability, traceability, and integration. These core features enable a secure system for the management and distribution of sensitive information. This study presents a concrete evaluation of the effectiveness of blockchain through an existing platform while revealing limitations from the perspectives of user adoption, cost-effectiveness, scalability, and regulatory frameworks.
Kearifan Lingkungan Masyarakat Dayak Benuaq dalam Novel Api Awan Asap: Kajian Ekokritik Giiford
Authors: Putri Nina Queena Hadi , Rahman Hasrul , Afifah Nisa Fitriyanti
Published: February 2020

Penelitian ini bertujuan untuk mendeskripsikan lima nilai kearifan lingkungan yang diturunkan dari kaidah estetika pastoral Giiford. Etstika Pastoral mendasari nilai kearifan lingkungan dalam sastra sebagai dasar kajian ekokritik sastra yang antroposentris, sehingga sastra tidak kehilangan fungsi kultural dan ekologisnya engenai landasan manusia dalam melestarikan alam berkaitan dengan sikap hormat, tanggung jawab, solidaritas, kasih saying dan kepedulian terhadap alam, serta tidak mengganggu kehidupan alam dalam novel Api Awan Asap karya (AAA) Korrie Layun Rampan (KLR). Jenis Penelitian ini merupakan deskriptif kualititif dengan metode content analysis Harold D. Laswell yang bertujuan untuk mengetahui isi dan makna yang terkandung dalam data yang dianalisis dengan pembahasan secara mendalam terhadap isi dari informasi tertulis, dalam hal ini adalah novel AAA yang ditulis sebagai jawaban terhadap isi kerusakan lingkungan yang disebabkan oleh masyarakat Dayak melalui pembakaran hutan. Kegiatan yang dilakukan adalah membaca, mencermati, menafsirkan, dan menganalisis novel AAA karya KLR. Sumber data dalam penelitian ini adalah novel AAA karya KLR dan literatur yang relevan. Teknik pengumpulan data dilakukan dengan teknik baca, teknik catat, dan teknik kajian kepustakaan. Hasil penelitian dapat disimpulkan bahwa terdapat lima nilai kearifan lingkungan dalam novel AAA karya karya KLR.
Flexa Ribeiro
Authors: Coutinho Maria Angélica da Gama Cabral , Gouvêa Fernando César Ferreira
Published: February 2020

A pesquisa ora apresentada busca compreender a importância do professor Flexa Ribeiro, secretário de educação do governo de Carlos Lacerda, entre os anos de 1960 e 1965, durante a elaboração do projeto de educação da Guanabara, à época de sua constituição como ente federativo, após a instalação da capital federal em Brasília. A investigação histórica busca reconstruir a trajetória biográfica do secretário, concentrando-se em fontes primárias: as notícias do jornal carioca “Tribuna da Imprensa”, do ano de 1962, focalizando o personagem e suas ações; e as cartas e os memorandos trocados entre Flexa e outras autoridades do governo estadual, sobretudo o governador e o secretário de governo, além de alguns parlamentares e diplomatas. Foi um período de muitas realizações, de grandes transformações no campo educacional, que ainda permanecem na memória do povo carioca. A pesquisa finaliza concluindo que, apesar de muitas das iniciativas no campo educacional serem reputadas à concepção do governador, na verdade foram empreendidas por seu secretário da pasta da educação.
Festividades cívico-patrióticas na formação da juventude brasileira nas cidades fronteiriças de Porto União (SC) e União da Vitória (PR) em 1941
Authors: Stentzler Márcia Marlene , Chelepa Marina Gabrielli Topolski
Published: February 2020

Neste artigo analisamos o papel de festividades e desfiles cívicos na formação da juventude nas cidades fronteiriças de União da Vitória (PR) e Porto União (SC), a partir do Decreto-Lei nº 2072, de 8 de março de 1940, que institui e fixa bases para a educação cívica, moral e física para crianças e jovens matriculados em estabelecimentos de ensino. Para isso, utilizamos fotografias localizadas no Arquivo Público de Florianópolis e notícias publicadas pelo periódico “O Comércio”, de Porto União (SC), revelando o entusiasmo com a formação da juventude e infância por ocasião da comemoração alusiva à Independência do Brasil e à Juventude Brasileira. A pesquisa é de cunho sócio-histórico e está vinculada ao Núcleo de Catalogação e Pesquisas em História da Educação (Nucathe), curso de Pedagogia da Unespar - União da Vitória (PR). Como base teórica, citamos Bencostta (2006; 2011); Hobsbawm (1990; 1998) e Horta (2012). Durante o Estado Novo, portanto, o culto aos símbolos pátrios durante sessões públicas tornou-se obrigatório para crianças e jovens estudantes de 7 a 18 anos, conformando uma cultura dentro de perspectivas ideológicas específicas do período ditatorial.
PERSEPSI KARYAWAN TERHADAP SISTEM PENENTUAN THE BEST EMPLOYEE OF THE YEAR DI HOTEL FAIRMONT SANUR BEACH BALI
Authors: Devi Afun Intan , Pantiyasa I Wayan
Published: February 2020

Tujuan dari penelitian ini adalah untuk mengetahui sistem penentuan karyawan terbaik tahun ini di Hotel Fairmont Sanur Beach Bali dan mengetahui persepsi karyawan tentang sistem indikator penentuan karyawan terbaik. Jenis data yang digunakan adalah data kualitatif dan data kuantitatif, sedangkan sumber data yang digunakan adalah data primer dan data sekunder. Teknik pengumpulan data yang digunakan adalah wawancara dan kuesioner menggunakan rumus Slovin dengan 156 sampel dari 225 pupulasi. Dan teknik analisis data yang digunakan adalah validitas, reliabilitas, dan analisis deskriptif kuantitatif. Hasil penelitian ini menunjukkan bahwa sistem penentuan karyawan terbaik di Hotel Fairmont Sanur Beach Bali menggunakan sistem formal yaitu penilaian seseorang yang memiliki wewenang formal untuk menilai bawahannya dan memiliki hak untuk menerapkan kebijakan lebih lanjut kepada karyawan tersebut, jadi penilaian formal ini akan menentukan apakah karyawan akan bergerak secara vertikal / horizontal, diberhentikan, atau layanan yang dikembalikan akan dinaikkan. Berdasarkan perhitungan skala likert dari 156 responden untuk lima indikator yaitu Relevansi, Sensitivitas, Keandalan, Akseptabilitas, dan Praktis memperoleh rata-rata di kisaran 3,8-4,2, yang berarti bahwa setiap indikator dianggap baik oleh karyawan.
Sociology of sports and the space of sports practices: Social genesis and sociological theories
Authors: Sharkov F. I. , Silkin V. V.
Published: February 2020

In recent years, the importance of sports in Russia has increased dramatically, which is determined primarily by the country’s hosting international sport events, in particular, the Olympics and the FIFA World Cup 2018. The influence of sports on social processes has increased, sports began to strengthen its position in public opinion as a prestigious sphere of employment and an important social category [24. P. 60]. Thus, there is an obvious need to identify the relationship of physical culture with society as a whole and with all elements of the social structure and specific social institutions. The article examines the origins and prerequisites for the formation of sociology of sport as a relatively independent scientific discipline; presents the issues of sports sociology in the historical perspective - in the context of both their social genesis and contemporary sociological theories; considers the social role and social functions of sport education and sports. The authors believe that the differentiated social distribution of sports practices is determined by the interconnections of the space of possible practices (supply) and the space of demand for certain practices. In the article, the well-known foreign scientists are presented in the new perspective - as sociologists who provided for both Russian and foreign authors the incentive and direction for theoretical studies of sports issues. The article also presents to Russian readers the original studies on sociology of sports conducted by famous scientists - Norbert Elias, Eric Dunning, Anna Ingram, Georges Hébert, etc.
Budget expenditures: less or more?
Authors: Zalevskaia T. D.
Published: February 2020

This article is a review of the book by V. Tanzi Pravitelstvo i rynki: menjajushchajasja rol gosudarstva [Government versus Markets: The Changing Economic Role of the State] (Moscow: Gaidar Institute Press, 2018. 584 p.). This is a book by a leading international expert on tax policy and its impact on the economic development, a former Head of the Office of Budget Affairs of the International Monetary Fund. Tanzi considers the economic role of the state in the 20-21 centuries in the historical and geographical context, and notes what the state should do or try to do in the economic sphere including in the near future. The review emphasizes that the book can be considered a kind of a guide on the analytical division of the market and the state, and also on the development of a strategy for overcoming budget crises of our time.
Social media: The development of a new McDonaldized institution
Authors: Shchekoturov A. V.
Published: February 2020

The article examines the phenomenon of social media from the perspective of the McDonaldization theory. The author considers social media as inextricably linked with the consumer society systems to show that such media have become a new McDonaldized institution, the study of which provides new theoretical and methodological possibilities. The article provides an overview of the studies proving the increasing McDonaldizing effect on various social institutions of the Russian society, and considers social media in terms of factors of the McDonaldization theory. Two social networks - Facebook and VK - are described in G. Ritzer’s concepts of ‘nothing’ and ‘something’ as the McDonaldized institutions. The author identifies the theoretical-methodological significance of considering social media as McDonaldized institutions; shows that social media functionally correspond to all five factors of Ritzer’s McDonaldization; explains why the social network Facebook is a grobalized form of ‘nothing’ and, thus, a driving force of globalization, while the social network VK is a glocal form of ‘nothing’ and, thus, creates unique meanings at the border of local and global levels. One of such new meanings is that the VK reflects the traditional interpretation of gender identity, sexual orientation and marriage. The author concludes that social media are a McDonaldized institution that can become a new research optics, which presupposes the use of mixed methods research.
ESTUDO COMPARATIVO DOS IMPACTOS ERGONÔMICOS DA UTILIZAÇÃO DE PROCESSOS FÍSICOS E ELETRÔNICOS NO PODER JUDICIÁRIO
Authors: Naiditch Isadora Franck , Funck Matheus , Sander Natália Eloísa , Lerman Laura Visintainer
Published: February 2020

Analisar um posto de trabalho sob o ponto de vista ergonômico possibilita garantir qualidade do serviço e produtividade, bem como, qualidade de vida e saúde aos trabalhadores. As funções daqueles que trabalham nas esferas do judiciário brasileiro envolvem a utilização de computadores e o levantamento de processos jurídicos que podem passar dos 12kg. Os dados foram coletados com um ano de intervalo sendo a primeira amostra ainda com processos físicos muito presentes e a segunda com a adoção dos processos eletrônicos. Utilizaram-se três métodos para avaliar os riscos de lesões e doenças relacionados às posturas adotadas durante estas atividades: RULA, diagrama das áreas dolorosas e NIOSH. Como resultados, as posturas adotadas no computador são inapropriadas, porém houve a redução de riscos de problemas na saúde com a eliminação dos levantamentos de cargas frequente.
Sostenibilidad - Recursos Naturales y su relación con la Sociedad Posmoderna en Guanacaste, Costa Rica
Authors: Morataya Montenegro Ricardo A. , Villegas Arguedas Juan Carlos , Oreamuno Herra Steven
Published: February 2020

El presente artículo hace una discusión crítica entre la sociedad postmoderna guanacasteca y su vinculación con los recursos con que cuenta. Esta relación se enfoca en tres sentidos: a) flora y fauna, b) recurso hídrico y c) urbanismo. Esto debido a que los recursos naturales de la región guanacasteca entran a jugar un papel importante para el desarrollo de la sociedad que se ha establecido desde mediados del siglo XX, dándose algunas dinámicas político-agrarias, y la consecuente destrucción “invisible” de los recursos naturales, siendo el indicador detonante de esa política la escases de agua en la región. El artículo describe a los recursos de flora y fauna y esa relación con la conservación y turismo, la cual busca hoy en día un equilibro sustentado el fortalecimiento del turismo rural, pero el crecimiento urbano y rural en cuanto a la interacción con el medio que le rodea aumentan la demanda por el recurso agua de forma integral (producción de bienes y consumo en el hogar).
Análisis multicriterio del modelo de gestión de la Reserva Biológica Bosque Nuboso Monteverde, Puntarenas, Costa Rica
Authors: Hernández Chaverri Rodolfo Antonio , Camacho Céspedes Fabricio , Hernandez Barrero Jeannette
Published: February 2020

Desde sus orígenes y a través de los años, la Reserva Bosque Nuboso Monteverde se han convertido en un referente internacional en cuanto a la conservación de los recursos naturales y la biodiversidad. La reserva no solamente ha logrado la protección de más de 4200 hectáreas de Bosque Nuboso, uno de los ecosistemas más amenazados por la deforestación y el cambio climático, sino que lo ha logrado en forma participativa e inclusiva con la comunidad local e internacional. El modelo de gestión de la reserva se enfoca en los tres pilares de la sostenibilidad: ambiental, social y económico. El modelo es robusto, pero es amenazado por su fuerte dependencia a los ingresos generados por el programa de ecoturismo. El equipo de gestión del área protegida debe buscar otras fuentes de financiamiento para fortalecer la sostenibilidad económica a mediano y largo plazo.
Pensiones para personas con discapacidad en Colombia
Authors: Parra-Dussan Carlos
Published: February 2020

In Colombia, the right to a pension, in any modality, is one of the mechanisms for guaranteeing the right to social security. In order to determine which pension regimes are more suited to the social and labor reality of the country’s people with disabilities, Colombian legislation and jurisprudence were reviewed through an exploratory-descriptive study method. It was found that this right gives special treatment to that population. Colombian legislation regulates at least ten kinds of pensions for this group of people with special constitutional protection.
Nota de retractación
Authors: Nino-Munoz Diana
Published: February 2020

Retractación de:  Seguridad del paciente y su percepción en los profesionales de la salud. Martínez Reyes, C., Agudelo Durango, J., Areiza Correa, S., y Giraldo Palacio, D. (Vol. 17 No. 33, 2017, pp. 277-292).  doi: 10.22518/usergioa/jour/ccsh/2017.2/a17
Law Enforcement to Transcendental Based of Paramedic Doctoroid Practices in Health Service
Authors: Soekiswati Siti , Absori Absori
Published: February 2020

Purpose of the study: This article aims to discuss the paramedic doctoroid practices in primary health care in Community Health Center conducted by paramedic doctors.Methodology: This research is socio-legal research; research on law application, viewing law acting as law in action, which involves the interrelation between law and social institutions.Main Findings: Delegation of duty policies under the roof of paramedic doctoroid practices in health services in Community Health Center. This research is a socio-legal aimed at uncovering the phenomenon of paramedic doctoroid practices.Applications of the study: The current study provides criticism for the government in creating inconsistent policies, poor supervision, and law enforcement behind doctoroid practice persistence.Novelty/Originality of the study: the concept of law enforcement is based on the philosophy of the first principle of Pancasila as the Indonesian ideology, transcendental-based law enforcement.
The Importance Of Moral Value Through Law Enforcement In Indonesia In Nonsystematic Legal Approach
Authors: Zuliyah Siti
Published: February 2020

ABSTRACT  Objective: This writing is purposed to explore the importance of moral value through law enforcement in Indonesia as basic dispensing justice, which is essential through a nonsystematic legal approach.  Methodology: This research using the philosophical approach method, which is purposed to explore the importance of moral value through law enforcement.  As it for the method used in this research is descriptive, then proceeded in interpretive. Invention: Nonsystematical legal approach views that jurisprudence is living and developing behavior patterns in society so that between law and moral can not be separated. In relation to the importance of moral value through law enforcement is intended as guidelines for law enforcement officer in the act of implementing their job well and responsibly, so that can give justice. Purpose: This research can help explain the importance of moral value through law enforcement so that can be a formulation of regulation or guidelines for law enforcement officer about how should take action in implementing law enforcement that becomes responsible properly. Recency/Originality: In relation to law enforcement in Indonesia, have been struggling at the positivist paradigm or systematic that bring law out of value and religion, so that just being instrumentalist tools. Therefore needed a new approach by accommodate moral value and religion to law enforcement optimized.               Keywords: Moral Value, Law Enforcement, Nonsystematic Legal Approach
Prophetical Law Paradigm: A Synthesis Of Thoughts Of Legal Philosophy Development
Authors: Yunianto Catur
Published: February 2020

ABSTRACT Purpose: This article aims to explain the philosophy dialectics of positivistic law and post positivistic law and elaborate on the dialectics of synthesis of thoughts of prophetic legal. Methodology: This research used a philosophical approach. The data were taken from secondary data using primary and secondary legal materials. The data were presented in an analytical descriptive manner, then analyzed in a normative juridical manner. Finding: The development of legal philosophy as an art of thought between empiricism, reality, rationality, and irrationality. Integration must be in presence to find the legal synthesis which is perceived capable of providing answers to the missing synthesis concerning the law. The basis of integration is conducted by retrieving the history and the thought schools development of natural philosophy, positivistic, non-systematic law and prophetic law. The synthesis of the thought schools of philosophical law is not only a reality built from the law itself but also the existence of extracurricular nullifications that can be synergized into near-perfect law. Benefit: The benefit of this research is to present the phenomena of various legal paradigms that develop simultaneously as a synthesis of legal development and as an answer to various problems of legal philosophy. The positivistic, non-systematic synthesis and the prophetic paradigm are the paths to near-perfect truth. Originality/Novelty: The prophetic paradigm developed within the framework of micro and macro realities are considered capable of providing answers to the reality of various criticisms that have existed so far. This prophetic paradigm has bonded micro, macro and transcendent realities which are divided into three categories; Theology, Humanity and Natural Sciences which are based on God’s verses on the Qur'an and Sunnah. Keyword: Philosophy of Law, Synthesis, Prophetic
Effect of energy and CO2 consumption on the economy in Sub-Sahara Africa
Authors: Ngonadi Josiah Chukwuma , Huaping Sun , Okere Joy , Ngonadi John Uche
Published: February 2020

The study focused on the long-term related effect among energy consumption (EC), CO2 production and economy growth (EG) of 12 randomly selected countries in sub-Saharan Africa. We used validation and causality tests in the 2008-2018 annual record. Special effects vary from country to country, in the long term, strong consumption of energy and economy growth in many countries has been linked with an increment in air pollution. The observation of the longitudinal study showed economic growth resulting in short-term CO2 emissions in Benin, the Democratic Republic of Congo, Ghana, Nigeria and Senegal, reflecting a lack of economy. This would not be possible without affecting the environment. The effect between CO2 and EG in Gabon, Nigeria and Togo has shown that environmental policies aimed at reducing pollution can be harmful. economic growth. In addition, long-term economic and CO2 production in Nigeria has been closely linked to the long-term links to Congo and Gabon. In the long-run, greenhouse gas emissions are the result of EC, EG and CO2 emission in Benin, Ivory Coast, Nigeria, Senegal, South Africa and Togo.