bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advances in Sodium Magnetic Resonance Imaging and Its Future Role in Kidney Disease
Authors: Akbari Alireza , McIntyre Christopher W.
Published: June 2023

Sodium imbalance is a hallmark of chronic kidney disease (CKD). Excess tissue sodium in CKD is associated with hypertension, inflammation, and cardiorenal disease. Sodium magnetic resonance imaging (23Na MRI) has been increasingly utilized in CKD clinical trials especially in the past few years. These studies have demonstrated the association of excess sodium tissue accumulation with declining renal function across whole CKD spectrum (early- to end-stage), biomarkers of systemic inflammation, and cardiovascular dysfunction. In this article, we review recent advances of 23Na MRI in CKD and discuss its future role with a focus on the skin, the heart, and the kidney itself.
A Case of Difficult Arterial Cannulation: Is Intra-Arterial Blood Pressure Monitoring an Absolute Requirement for Paediatric Liver Transplantation?
Authors: McKevitt Helen , Milan Zoka
Published: June 2023

Invasive arterial blood pressure monitoring is the standard of practice in terms of intraoperative blood pressure surveillance during liver transplantation. While this is an ideal, achieving reliable arterial access can be extremely challenging in the paediatric and neonatal population, repeated attempts at arterial cannulation are not without risk and alternative best practice means of haemodynamic monitoring are not clearly established. We describe a case of paediatric liver transplantation in a 3.9 kg infant that was complicated by difficult arterial cannulation, and we suggest that, when reasonable attempts to achieve intra-arterial access have failed, it is safe to proceed with paediatric liver transplantation with non-invasive blood pressure monitoring at 2 min intervals throughout the case and 1 min intervals at reperfusion. We recognise the unique technical challenges in paediatric liver transplant anaesthesia, and we advocate for the establishment of formal clinical training competencies in line with adult practice recommendations. We recommend the use of the Seldinger technique under ultrasound guidance as a first-line approach when difficult arterial cannulation is anticipated, and we discuss techniques for alternative approaches. We suggest that additional alternative means of haemodynamic monitoring should be considered when arterial access cannot be established; however, as no method demonstrates absolute superiority, one or a combination of techniques should be considered, depending on local availability and expertise.
Complicated Pocket Infection in Patients Undergoing Lead Extraction: Characteristics and Outcomes
Authors: Milman Anat , Wieder-Finesod Anat , Zahavi Guy , Meitus Amit , Kariv Saar , Shafir Yuval , Beinart Roy , Rahav Galia , Nof Eyal
Published: June 2023

Cardiac implantable electronic device (CIED) infection can present with pocket or systemic manifestations, both necessitating complete device removal and pathogen-directed antimicrobial therapy. Here, we aim to characterize those presenting with both pocket and systemic infection. A retrospective analysis of CIED extraction procedures included 300 patients divided into isolated pocket (n = 104, 34.7%), complicated pocket (n = 54, 18%), and systemic infection (n = 142, 47.3%) groups. The systemic and complicated pocket groups frequently presented with leukocytosis and fever > 37.8, as opposed to the isolated pocket group. Staphylococcus aureus was the most common pathogen in the systemic and complicated pocket groups (43.7% and 31.5%, respectively), while Coagulase-negative staphylococci (CONS) predominated (31.7%) in the isolated pocket group (10.6%, p < 0.001). No differences were observed in procedural success or complications rates. Kaplan–Meier survival analysis found that at three years of follow-up, the rate of all-cause mortality was significantly higher among patients with systemic infection compared to both pocket groups (p < 0.001), with the curves diverging at thirty days. In this study, we characterize a new entity of complicated pocket infection. Despite the systemic pattern of infection, their prognosis is similar to isolated pocket infection. We suggest that this special category be presented separately in future publications of CIED infections.
Contribution of Various Shale Components to Pore System: Insights from Attributes Analysis
Authors: Xu Lingling , Pan Renfang , Hu Huiyan , Meng Jianghui
Published: June 2023

Shale pore systems are the result of the geological evolution of different matrix assemblages, and the composition of gas shale is considered to affect the pore systems in shale reservoirs. This study aimed to investigate the impact of both organic and inorganic constituents on the shale pore system, including specific surface area (SSA) and pore volume in Wufeng–Longmaxi Shale. Multiple linear regression (MLR) was employed to examine the contributions of different components to shale pore structure. The pore structure parameters, including pore SSA and pore volume, were obtained by gas adsorption experiments in 32 Wufeng–Longmaxi Shale (Late Ordovician–Early Silurian) samples. Both pore SSA and pore volume were calculated by the density functional theory (DFT) model on shale samples, and the pore types were determined by high-resolution field emission scanning electron microscopy (FE-SEM). The results of the X-ray diffractometer (XRD) analysis indicate that the Wufeng–Longmaxi Shale is dominated by quartz, clays, carbonates, feldspar, pyrite, and organic matter. Four models were made using SPSS software, all of which showed significant correlation between shale pore size and organic matter (OM) and clays. The content of organic matter played the biggest role in determining the size and structure of the pores. Although the content of quartz is the highest and serves as a rigid skeleton in shale reservoirs, it has complicated effects on the pore structure. In this study, most of the quartz is biogenetic and part of it is transformed from clays in deep shale. Therefore, these two parts of quartz are, respectively, related to organic matter and clays. In essence, the pores related to these two parts of quartz should be attributed to organic matter and clays, which also support the conclusion of the MLR models.
Inverse Evaluation of Monopile Pile–Soil Interaction Parameters Using Random Search
Authors: Qiao Hou , Li Wei , Jiang Zhenqiang , Sheng Xi , Guo Chuanrui
Published: June 2023

To deal with the uncertainties in modeling offshore wind turbines, we propose a parameter inversion method for the pile–soil interaction model based on structural health monitoring results and the numerical model. The proposed parameter inversion method has a numerical model, an objective function selected using both the numerical and identified results, and an inverse optimization using a random search algorithm in the assumed parameter space. The parameter results in the minimum optimization objective function are identified as the in situ parameter. The proposed method is confirmed to converge after some number of iterations, depending on what the initial parameter values are. However, different initial parameter cases may converge to slightly different optimal parameters, implying that the pile results are sensitive to geological parameters. Moreover, a comparison with the original design results shows design redundancy or risks. Though the proposed method has several flaws, it can shed light on the influence of parameter uncertainties on offshore wind turbines.
Main Physical Processes Affecting the Residence Times of a Micro-Tidal Estuary
Authors: Hewageegana Viyaktha Hithaishi , Olabarrieta Maitane , Gonzalez-Ondina Jose M.
Published: June 2023

Residence time is an important parameter linked to the water quality in an estuary. In this paper, we identify and analyze the main processes that affect the residence time of the Caloosahatchee River Estuary, a micro-tidal and mixed diurnal-semidiurnal estuary located in western Florida. Multiyear validated hydrodynamic hindcast results were coupled with an offline particle tracking model to compute the residence time of the estuary, which showed a strong seasonality driven by the river discharge. The residence time reduced with increasing river flow. The wind velocity and direction also affected the residence time. The influence of the wind was dependent on the magnitude of the river discharge. In general, upstream-directed wind increased residence time, while downstream-directed wind decreased residence time. Downstream wind during the dry period reduced residence time on average by a week. Processes such as water density gradient-induced circulation and particle buoyancy also influenced the residence time of the estuary. The outcomes of this study can be used to better understand the influence of the main physical processes affecting the residence time at other similar estuaries and to help in the management of the estuaries to improve their water quality.
Comparison between the Employment of a Multibeam Echosounder on an Unmanned Surface Vehicle and Traditional Photogrammetry as Techniques for Documentation and Monitoring of Shallow-Water Cultural Heritage Sites: A Case Study in the Bay of Algeciras
Authors: Solana Rubio Soledad , Salas Romero Alberto , Cerezo Andreo Felipe , González Gallero Raúl , Rengel Juan , Rioja Luis , Callejo Joaquín , Bethencourt Manuel
Published: June 2023

Over the last few years, due to various climatic, anthropogenic, and environmental factors, a large amount of submerged heritage has been unearthed and exposed to deterioration processes in the Bay of Algeciras. These impacts can be more severe in shallow waters, where the cultural heritage is more vulnerable to natural and human-induced impacts. This makes it urgent to document cultural heritage at risk of disappearing using different techniques whose efficiencies in the archaeological record need to be determined and compared. For this purpose, we have documented a shipwreck in the Bay of Algeciras using two techniques: photogrammetry and a multibeam echosounder. The photogrammetric method consists of obtaining a 3D model from numerous photographs taken of an object or a site. The processing software creates three-dimensional points from two-dimensional points found in the photographs that are equivalent to each other. Multibeam echosounders are capable of providing side scan imagery information in addition to generating contour maps and 3D perspectives of the surveyed area and can be installed in an unmanned surface vehicle. As a result, we have obtained two 3D visualisations of the shipwreck, i.e., digital copies, that are being used both for the analysis of its naval architecture and for its dissemination. Through the comparison of the two techniques, we have concluded that while a multibeam echosounder provides a detailed digital terrain model of the seabed, photogrammetry performed by divers gives the highest resolution data on objects and structures. In conclusion, our results demonstrate the benefits of this combined approach for accurately documenting and monitoring shipwrecks in shallow waters, providing valuable information for conservation and management efforts.
Analysis of the Steady-Stream Active Flow Control for the Blended-Winged-Body Underwater Glider
Authors: Du Xiaoxu , Liu Xin , Song Yani
Published: June 2023

The BWB-UG is a glider with a smooth and integrated fuselage and wing. Its lift-to-drag properties are some of the most significant factors affecting its performance. In order to improve its hydrodynamic characteristics, the method of steady-stream active flow control (SS-AFC) is proposed. The computational fluid dynamics method is used to numerically investigate the SS-AFC of the BWB-UG. The mechanism of the SS-AFC effect on the lift-to-drag characteristics is revealed from the flow field aspect. The flow field of the BWB-UG before and after installing the SS-AFC was simulated using FLUENT. The results show that the SS-AFC can effectively optimise the hydrodynamic characteristics of the BWB-UG and can optimise the structure of the flow field around the BWB-UG. The steady-suction AFC can increase the lift-to-drag ratio of the BWB-UG by up to 45.01%. With the steady-jet AFC, the lift-to-drag ratio of the BWB-UG can be increased by as much as 93.17%.
Long-Term Safety of Omalizumab in Children with Asthma and/or Chronic Spontaneous Urticaria: A 4-Year Prospective Study in Real Life
Authors: Galletta Francesca , Caminiti Lucia , Lugarà Cecilia , Foti Randazzese Simone , Barraco Paolo , D’Amico Federica , Irrera Pierangela , Crisafulli Giuseppe , Manti Sara
Published: June 2023

Background: Insufficient data are available on the long-term “real-life” safety profile of omalizumab in children. This study evaluated the long-term safety of omalizumab in a pediatric cohort with severe asthma or chronic spontaneous urticaria (CSU). Methods: A monocentric, prospective study evaluated the long-term safety of omalizumab in patients aged 6–18 years. Each patient completed the standardized MedDRA questionnaire to identify adverse events (AEs). Results: In total, 23 patients, median age 15 (14–18) years, affected by severe asthma (60.8%) or CSU (39.2%), treated with omalizumab for 2 (1–4) years were enrolled. The most common AEs belong to the system organ class (SOC) of general disorders and administration-site conditions (37.17%). Skin and subcutaneous tissue problems represent the second most frequently reported AEs (24.35%). Central nervous system and musculoskeletal disorders were quite frequent (15.38% and 8.97%, respectively). Other adverse events were tachycardia (5.12%), vertigo and abdominal pain (2.60% and 3.86%, respectively), and dry eye (1.3%). Only one patient reported herpes virus infection during treatment (1.3%). No cases of anaphylaxis, hemopathies, uronephropathies, respiratory, psychiatric, hepatobiliary, or oncological pathologies were reported. Conclusions: Long-term “real-life” treatment with omalizumab in children appears well tolerated. Its safety and efficacy profile makes omalizumab an excellent alternative in severe asthma and CSU in children.
“Single Knot–Single Running Suture” Vesicourethral Anastomosis with Posterior Musculofascial Reconstruction during Robot-Assisted Radical Prostatectomy: A Step-by-Step Guide of Surgical Technique
Authors: Flammia Rocco Simone , Bologna Eugenio , Anceschi Umberto , Tufano Antonio , Licari Leslie Claire , Antonelli Luca , Proietti Flavia , Alviani Federico , Gallucci Michele , Simone Giuseppe , Leonardo Costantino
Published: June 2023

Background: Our aim is to describe Gallucci’s (VV-G) technique for vesicourethral anastomosis and posterior musculofascial reconstruction (PMFR) during robot-assisted radical prostatectomy (RARP) and to assess early urinary continence recovery and perioperative outcomes. VV-G consists of a “single knot–single running suture” vesicourethral anastomosis with PMFR. Methods: Between September 2019 and October 2021, we prospectively compared VV-G vs. conventional Van Velthoven anastomosis (VV-STD) during RARP. We excluded patients with urinary incontinence, pelvic radiotherapy, and urethral and BPH surgery prior to RARP. Social continence (SC) recovery, perioperative complications, and length of hospital stay (LOS) were compared between VV-G vs. VV-STD. SC was defined as 0–1 pad/die. We applied 1:1 propensity score matching (PSM) adjusting for different covariates (age, Charlson Comorbidity Index, BMI, prostate volume, nerve-sparing and lymph node dissection). Results: From 166 patients, 1:1 PSM resulted in two equally sized groups of 40 patients each with no residual differences (all p ≥ 0.2). VV-G yielded higher 3-month SC rates than VV-STD (97.5 vs. 55.0%, p < 0.001). A tiny difference was still recorded at one-year follow-up (97.5 vs. 80.0%, p = 0.029, HR: 2.90, 95% CI: 1.74–4.85, p < 0.001). Conversely, we observed no differences in any perioperative complications (15.0 vs. 22.5%, OR: 0.61, 95% CI 0.19–1.88, p = 0.4) and LOS (3 vs. 4 days, Δ: −0.69 ± 0.61, p = 0.1). Conclusions: VV-G significantly improved early SC recovery without increasing perioperative morbidity. In our opinion, VV-G represents an easy-to-learn and easy-to-teach technique due to its single-suture, single-knot, and symmetrical design.
Hydrologic Effectiveness and Economic Efficiency of Green Architecture in Selected Urbanized Catchment
Authors: Widomski Marcin K. , Musz-Pomorska Anna , Gołębiowska Justyna
Published: June 2023

This paper presents a numerical assessment of the influence of green roofs applied in the urbanized catchment on the rainwater outflow hygrogram as well as costs and economic efficiency analysis of the proposed green architecture application. The campus basin of the Lublin University of Technology, Poland, was selected as the object of the study. Three variants of extensive green roof applications were designed. The numerical model of surface runoff was developed in US EPA’s SWMM 5.2 software. The simulations were performed for three different rainfall events of various intensities and durations. The cost efficiency of the proposed green architecture was assessed by the Dynamic Generation Costs indicator, while economic effectiveness was tested by Benefits–Costs Ratio and Payback Period determined for all assumed variants. The determination of economic efficiency indicators was based on investment and maintenance costs estimation, assumed discount rate, and time duration of assessment. Results of numerical calculations showed up to 16.81% of peak flow and 25.20% of runoff volume reduction possibly due to the green roof application. All proposed variants of green roof applications in the studied urbanized catchment were assessed as generally profitable due to possible financial benefits related to heating and cooling energy savings and avoiding periodical change of bitumen roof cover.
Farmland Transfer Participation and Rural Well-Being Inequality: Evidence from Rural China with the Capability Approach
Authors: Han Wenjing , Fu Yang , Sun Wen
Published: June 2023

Participation in the farmland transfer market provides farmers with diversified opportunities which would generate a range of social and economic benefits to improve their overall well-being. However, the previous studies have disproportionately focused on the income increase of farmers’ participation while ignoring its impact on other dimensions significantly contributing to the well-being gap of farmers with different social and economic characteristics. Based on the capability approach, this study constructed a multi-dimensional well-being assessment framework and employed the fuzzy method to evaluate the well-being level of rural households. By employing the national rural survey data from China, this paper examined the impact of farmland transfer participation on the well-being of farmers with different livelihoods. Further, it explored the influence of farmland transfer participation on the well-being gap of farmers by using the quantile regression method. Our results suggest that farmland transfer participation played a positive role in increasing farmers’ well-being, while farmland transfer participation has no significant impact on farmers’ well-being inequality. Meanwhile, the heterogeneity of farmers’ livelihoods is the key factor for the differentiation of farmers’ well-being.
Four Secular Ruke Dongba Notes Generated during Fieldwork: An Innovative Language Documentation Approach
Authors: Xu Duoduo
Published: June 2023

This paper documents and analyzes several Dongba script notes collected during my interviews with the Ruke Dongba priests. It provides an overview of Ruke Dongba glyphs in processing daily vocabulary and the International Phonetic Alphabet. It compares these Dongba pictographs with the Geba script, the syllabic writing system of Naxi people, as well as the various types of scripts used by some other ethnic groups, which show a general tendency of Romanization in the generation of alphabetic writing systems and provides a pattern inherent in the historical evolution of writing. IPA symbols, a fundamental tool of field linguists, facilitate learners in grasping a language and nonalphabetic scripts. In addition to analyzing the Ruke Dongba pictographs attested in the secular manuscripts in the context of history of writing, this study contributes to the linguistic description of Ruke Dongba culture and the diversity of Dongba tradition.
Phonology of Adur Niesu in Liangshan, Sichuan
Authors: Ding Hongdi
Published: June 2023

This study describes the segmental and suprasegmental phonology of Adur Niesu, a Loloish (or Ngwi) language spoken mainly in Liangshan, Sichuan, southwest China. Phonemically, there are 41 consonants, 10 monophthongs and 1 diphthong in Adur Niesu. All Adur syllables are open. Its segmental changes mainly happen to the vowels, featuring high vowel fricativization, vowel lowering, vowel centralization, vowel assimilation and vowel fusion. It is common for Adur Niesu syllables to be reduced in continuous speech, with floating tones left. There are three main types of syllable reduction: complete reduction including the segment and tone, partial reduction with a floating tone left, and partial reduction with the initial consonant left. Adur Niesu employs tones as an important means for lexical contrast, namely, high-level tone 55, mid-level tone 33, and low-falling tone 21. There is also a sandhi tone 44. There are two types of tonal alternation: tone sandhi and tone change. Tone sandhi occurs at both word and phrasal levels, and is conditioned by the phonetic environment, while tone change occurs due to the morphosyntactic environment. Finally, some seeming tonal alternation is the result of a floating tone after syllable reduction.
Selection and Molecular Characterization of Promising Plum Rootstocks (Prunus cerasifera L.) among Seedling-Origin Trees
Authors: Korkmaz Kubra , Bolat Ibrahim , Uzun Aydın , Sahin Muge , Kaya Ozkan
Published: June 2023

The plum (Prunus cerasifera Ehrh) has been used worldwide both as a genetic source for breeding new rootstocks and as clonal rootstock for many Prunus species. Considering situations where wild relatives of plums are endangered, in-depth characterization of rootstock traits of genetic diversity of plum germplasm of Turkey with many ecogeographical locations is crucial. In the present study, therefore, three steps were followed for the selection of rootstock candidates among the plum germplasm grown in the Middle Euphrates. This region is characterized by an extremely hot climate with extremely warm summers and very low precipitation in summers. Initially, 79 rootstock candidates were selected based on rootstocks traits, and Myrobalan 29C was also used for the control rootstock in all steps. Hardwood cuttings were taken from each rootstock candidate, and after the rooting process in rootstock candidates, 39 rootstock candidates outperforming other candidates were selected according to root characteristics. Based on rooting ability, forty rootstock candidates with the longest root length below 33.50 mm, root number below 3.00, and rooting cutting number below 30.00% were eliminated. The second step of the study focused on the dwarfing characteristics of 39 rootstock candidates, and 13 and Myrobalan 29C out of 39 rootstock candidates’ dwarfing traits showed value higher compared to the other 26 rootstock candidates. Results indicated that the vigor of rootstock candidates was usually found to be strong (26), intermediate (4), and weak (9). Moreover, 13 out of 39 rootstock candidates’ dwarfism trait was better than the other 26 rootstock candidates. In Step 3, some morphological, physiological, and molecular evaluations were conducted in 13 rootstock candidates and the Myrobalan 29C clone, and there were significant differences between both rootstock candidates and the parameters evaluated. PCA has also been indicated that the reference rootstock Myrobalan 29C was grouped with 63B62, 63B69, and 63B14. The highest genetic similarity was found between 63B11 and 63B16, as well as between 63B76 and 63B66, while the lowest genetic similarity was observed between 63B72 and 63B61 candidates. Overall, the findings presented here provide valuable information about the level of rootstock candidates that could potentially be superior among previously uncharacterized plum cultivars in this plum-growing region of Turkey.
Outcomes of Pregnancy in COVID-19-Positive Mothers in a Tertiary Centre
Authors: Subramaniam Vigneshwaran , Ng Beng Kwang , Phon Su Ee , Muhammad Rafi’uddin Hamizan , Wira Sorfan Abd Razak , Siti Hajar Abd Azman , Nor Azlin Mohamed Ismail
Published: June 2023

Background: COVID-19 is an emerging global pandemic with potential adverse effects during pregnancy. This study aimed to determine the adverse maternal and foetal outcomes due to COVID-19 infection. We also compared maternal and neonatal outcomes with regard to the timing of diagnosis (first and second trimester vs. third and fourth trimester); early COVID-19 (stage I and II) vs. severe-stage COVID-19 (III, IV, and V); and lastly, women who were partially vaccinated vs. unvaccinated. Methods: This was a retrospective study conducted in HCTM from January 2021 to January 2022. All pregnant women admitted for COVID-19 infections were recruited. The patients’ records were traced. Adverse maternal and neonatal outcomes were documented and analysed. Results: There were 172 pregnant women recruited into this study. We excluded twenty-four patients with incomplete data and nine women who delivered elsewhere. The final 139 patients were available for data analysis. The majority of women were in their third trimester of pregnancy (87.8%); however, only 5.0% and 7.2% were in the first and second trimesters, respectively. The study population had a median BMI of 29.1 kg/m2 and almost half of them had never received a COVID-19 vaccination. A sub-analysis of data concerning adverse maternal and foetal outcomes comparing early vs. severe stages of COVID-19 infection showed that severe-stage disease increased the risk of preterm birth (54.5% vs. 15.4%, p < 0.001) and preterm birth before 34 weeks (31.9% vs. 2.6%, p < 0.001) significantly. The severe-stage disease also increased NICU admission (40.9% vs. 15.4%, p = 0.017) with lower birth weight (2995 g vs. 2770 g, p = 0.017). The unvaccinated mothers had an increased risk of preterm birth before 34 weeks and this was statistically significant (11.6% vs. 2.9%, p = 0.048). Conclusions: Adverse pregnancy outcomes such as ICU admission or patient death could occur; however, the clinical course of COVID-19 in most women was not severe and the infection did not significantly influence the pregnancy. The risk of preterm birth before 34 weeks was higher in a more severe-stage disease and unvaccinated mother. The findings from this study can guide and enhance antenatal counselling of women with COVID-19 infection, although they should be interpreted with caution in view of the very small number of included cases of patients in the first and second trimesters.
Analysis and Optimization of the Milling Performance of an Industry-Scale VSM via Numerical Simulations
Authors: Tong Chengguang , Chen Zuobing , Liu Chang , Xie Qiang
Published: June 2023

Vertical stirred mills (VSM) are widely used for powder processing in many situations like mechanical alloying preparation and raw material crushing and shaping. Many structural and operational parameters like stirrer helix angle and rotating speed have great significance on VSM performance, especially in a large industry-scale situation. Therefore, it becomes essential to investigate these parameters systematically to obtain high energy efficiency and good product quality. In this work, the discrete element method (DEM) was used to examine the effects of stirrer helix angle (α), stirrer diameter (d), and rotating speed (n) on the grinding performance in an industrial VSM, and then the response surface method (RSM) was employed for multi-objective optimization in the VSM. It is found that a media vortex phenomenon may happen near the stirring shaft. The media collisions are significantly influenced by α, d, and n. Through multi-objective optimization design (MOD), the power consumption (P) of the stirrer reduced by 8.09%. The media collision energy (E) increased by 9.53%. The energy conversion rate (R) rises by 20.70%. The collision intensity and frequency are both improved. This optimization method can help determine good operating parameters based on certain structures.
Evolution and Influencing Mechanisms of the Yili Loess Mechanical Properties under Combined Wetting-Drying and Freeze-Thaw Cycling
Authors: Zhang Yongliang , Zhang Zizhao , Hu Wanhong , Zhang Yanyang
Published: June 2023

Landslides frequently occur in the loess-rich Yili region of Xinjiang, China, due to the combined effects of wetting-drying and freeze-thaw (WD-FT) cycles, which cause changes in the soil/loess internal structure and shear strength. This paper explores the combined effect of WD-FT cycles on the shear strength evolution of Yili loess through cyclic and triaxial shear tests. The micromechanism of the effect of WD-FT cycles on the loess properties is studied through scanning electron microscopy tests. Finally, the gray correlation analysis method assesses the correlation between relevant macro and micro parameters. The results show that: (1) With the increase in WD-FT cycles, the cohesion of loess decreases first and then gradually stabilizes, while the internal friction angle first grows and then drops before stabilizing. This indicates that the WD-FT cycles cause different degrees of decline in the soil’s internal friction angle and cohesion. (2) As the number of WD-FT cycles increases, the average abundance and directional probability entropy fluctuate slightly, gradually decreasing and stabilizing. In contrast, the particle size dimensionality gradually decreases and stabilizes, and the pore area ratio first increases and then gradually stabilizes. (3) Six microstructural parameters (average diameter, average abundance, particle size dimensionality, directional probability entropy, particle roundness, and pore area) are selected for correlation analysis with the shear strength index of loess. The results show that the particle size dimensionality closely correlates with macroscopic internal friction angle under coupled cycling, while the pore area closely correlates with macroscopic cohesion. These findings are instrumental in preventing and controlling loess landslides caused by WD-FT cycles in the Yili region of Xinjiang, China, and similar loess-rich regions.
Experimental and Simulation Study of the Fracture Instability Behavior in Polypropylene Fiber-Reinforced Concrete
Authors: Cao Peng , Cao Liang , Chen Guoqing , Shi Feiting , Zhou Changjun , Wang Jianru
Published: June 2023

This study investigated the fracture characteristics of plain concrete and polypropylene fiber-reinforced concrete (PFRC) using pre-notched three-point bending beam tests with the digital speckle correlation method (DSCM). Then, the fracture instability behavior of the two types of beams was simulated in finite elements based on the plastic damage model and the cohesion model, for which the applicability was assessed. Furthermore, the stability of the Big Gang Mountain Dam made from plain concrete or PFRC subjected to the earth-quake loading was simulated with the plastic damage model. The results show that the limiting length of the non-local deformation zone can be used as an indicator of instability damage in a concrete structure. The simulation results of the plastic damage model agreed well with the local deformation in the pre-notched three-point bending beam test obtained from the DSCM. The plastic damage model was found to be capable of describing the residual strength phenomenon, which the cohesive model was not capable of. The damage evolution regions of the PFRC dam are strictly constrained in some regions without the occurrence of the local deformation band across the dam, and PFRC can dramatically reduce the failure risk under earthquake loading. The numerical solution proves that PFRC is an advisable material for avoiding failure in concrete dams.
Effect of Metal Coating on Displacement of the Silicon Electrothermal V-Shaped Actuator
Authors: Dai Fengqi , Liu Shuangjie , Hao Yongping , Liu Fengli
Published: June 2023

Electrothermal actuation is widely employed in MEMS systems, and the electrothermal V-shaped actuator (referred to as EVA) has garnered attention due to its stable output force. However, current EVAs in MEMS face the challenge of limited driving displacement. To investigate the impact of metal coating on the driving displacement of silicon EVAs, a mechanical model is established, and a formula for calculating the maximum displacement is derived. The theoretical analysis results are compared between cases with and without metal coating. To validate the formula’s accuracy, the COMSOL simulation platform is utilized, employing the finite element method to model and simulate actuators with various metal coatings. The analysis demonstrates that the calculated results have a maximum error of 10% compared to the simulation results. The metal coating enhances the displacement of silicon EVAs to different degrees, with a more pronounced effect observed for metal coatings with lower resistivity. Notably, a copper metal coating doubles the displacement of silicon EVAs at a voltage of 4 V. In other words, under the same displacement, a silicon EVA with a metal coating requires a lower input voltage compared to the group without a metal coating, resulting in a significant voltage reduction of 33.75%.
Decoding the Profitability of Insurance Products: A Novel Approach to Evaluating Non-Participating and Participating Insurance Policies
Authors: Yang Chih-Te , Ni Yensen , Yu Mu-Hsiang , Chen Yuhsin , Huang Paoyu
Published: June 2023

This study presents a novel approach to analyzing the present value of total profit for non-participating and participating insurance policies in order to determine the optimal profitability of non-participating and participating insurance policies based on applying the approach used in operations research to the field of finance. As such, a comprehensive insurance product evaluation model was developed using both mathematical models and numerical analysis to evaluate the demand for non-participating and participating life insurance policies in response to changes in interest rates. The findings indicate that non-participating life insurance policies offer greater solvency for insurance companies compared to participating policies. The study also highlights the significance of spontaneous and induced demand in determining the total profit of both types of policies. The study concludes that life insurance companies should focus on generating spontaneous consumer demand, reducing induced demand, and implementing the optimal pricing strategy to achieve maximum profits.
Univariate Probability-G Classes for Scattered Samples under Different Forms of Hazard: Continuous and Discrete Version with Their Inferences Tests
Authors: Eliwa Mohamed S. , Tahir Muhammad H. , Hussain Muhammad A. , Almohaimeed Bader , Al-Bossly Afrah , El-Morshedy Mahmoud
Published: June 2023

In this paper, we define a new generator to propose continuous as well as discrete families (or classes) of distributions. This generator is used for the DAL model (acronym of the last names of the authors, Dimitrakopoulou, Adamidis, and Loukas). This newly proposed family may be called the new odd DAL (NODAL) G-class or alternate odd DAL G-class of distributions. We developed both a continuous as well as discrete version of this new odd DAL G-class. Some mathematical and statistical properties of these new G-classes are listed. The estimation of the parameters is discussed. Some structural properties of two special models of these classes are described. The introduced generators can be effectively applied to discuss and analyze the different forms of failure rates including decreasing, increasing, bathtub, and J-shaped, among others. Moreover, the two generators can be used to discuss asymmetric and symmetric data under different forms of kurtosis. A Monte Carlo simulation study is reported to assess the performance of the maximum likelihood estimators of these new models. Some real-life data sets (air conditioning, flood discharges, kidney cysts) are analyzed to show that these newly proposed models perform better as compared to well-established competitive models.
Design Approach for Evolutionary Techniques Using Genetic Algorithms: Application for a Biped Robot to Learn to Walk and Rise after a Fall
Authors: Szabo Roland
Published: June 2023

In this research, a biped robot is programmed to learn to walk using genetic algorithms. The biped robot has the ability to rise after a fall. The system is made according to human genetics, where a child tries to learn to walk, takes a few steps, falls, and then stands up somehow after a fall. After this process, the system restarts and tries to walk again. The biped robot evolves after each generation, and after each generation it will have a more natural walking posture. The system is unpredictable, because the biped robot sometimes evolves faster and sometimes evolves slower, like in human genetics where some children are faster and other children are slower to walk. The biped robot is considered to have evolved enough after having a walking posture similar to that of a human and does not fall.
Marine Resources Offer New Compounds and Strategies for the Treatment of Skin and Soft Tissue Infections
Authors: Labes Antje
Published: June 2023

Bioprospecting of the marine environment for drug development has gained much attention in recent years owing to its massive chemical and biological diversity. Drugs for the treatment of skin and soft tissue infections have become part of the search, mainly with respect to enlarging the number of available antibiotics, with a special focus on multidrug-resistant Gram-positive bacteria, being the major causative agents in this field. Marine resources offer novel natural products with distinct biological activities of pharmaceutical importance, having the chance to provide new chemical scaffolds and new modes of action. New studies advance the field by proposing new strategies derived from an ecosystemic understanding for preventive activities against biofilms and new compounds suitable as disinfectants, which sustain the natural flora of the skin. Still, the development of new compounds is often stuck at the discovery level, as marine biotechnology also needs to overcome technological bottlenecks in drug development. This review summarizes its potential and shows these bottlenecks and new approaches.
New Assessment Tool—Postpartum Functional Assessment Questionnaire
Authors: Filipec Manuela , Blagaić Vladimir , Jadanec Đurin Marinela , Zekan Paulo , Hrabač Pero , Zovko Ana
Published: June 2023

Background and Objectives: Functional status of the mother after delivery is crucial for performing activities of daily living and caring for the newborn. It is important to assess functional abilities after childbirth in order to improve the quality of postpartum care. The aim of this study is to determine the psychometric properties of the questionnaire and assess the functional abilities after childbirth. Materials and Methods: This study is observational. Postpartum Functional Assessment Questionnaire includes eleven items. 301 women after childbirth, 234 after vaginal birth and 67 after caesarean section participated in the study. An assessment of pain intensity and functional abilities was performed on the first and third day after childbirth. The Factor and Cronbach’s alpha analyses were performed to determine the factor structure and internal consistency. Results: The analysis reveals two factors, with seven items loading on factor 1 and four on factor 2. Cronbach’s alpha for construct I (Mobility) at the first day was 0.927 and at the third day was 0.913; and for Factor II (Self-care) at the first day was 0.846 and at the third day was 0.894. All between-group differences in pain intensity and functional abilities were highly statistically significant (p < 0.001). Differences between the first and third postpartum day were statistically significant for all variables and all subgroups (p < 0.001). Conclusions: Postpartum Functional Assessment Questionnaire has good psychometric properties and is a valuable tool for use in clinical practice.
Multimodality Cardiac Imaging in COVID-19 Infection
Authors: Militaru Sebastian , Mihu Anca , Genunche-Dumitrescu Amelia Valentina , Neagoe Carmen Daniela , Avramescu Taina Elena , Istratoaie Octavian , Gheonea Ioana-Andreea , Militaru Cristian
Published: June 2023

COVID-19 infection often produces cardiovascular complications, which can range from mild to severe and influence the overall prognosis. Imaging is the cornerstone for diagnosing initial COVID-19 cardiovascular involvement as well as treatment guidance. In this review, we present the current state of the literature on this subject while also emphasizing possible algorithms for indicating and executing these investigations.
Molecular and Functional Characterisation of a Novel Intragenic 12q24.21 Deletion Resulting in MED13L Haploinsufficiency Syndrome
Authors: Siavrienė Evelina , Petraitytė Gunda , Mikštienė Violeta , Maldžienė Živilė , Sasnauskienė Aušra , Žitkutė Vilmantė , Ambrozaitytė Laima , Rančelis Tautvydas , Utkus Algirdas , Kučinskas Vaidutis , Preikšaitienė Eglė
Published: June 2023

Background and Objectives: Heterozygous pathogenic variants in the MED13L gene cause impaired intellectual development and distinctive facial features with or without cardiac defects (MIM #616789). This complex neurodevelopmental disorder is characterised by various phenotypic features, including plagiocephaly, strabismus, clubfoot, poor speech, and developmental delay. The aim of this study was to evaluate the clinical significance and consequences of a novel heterozygous intragenic MED13L deletion in a proband with clinical features of a MED13L-related disorder through extensive clinical, molecular, and functional characterisation. Materials and Methods: Combined comparative genomic hybridisation and single-nucleotide polymorphism array (SNP-CGH) was used to identify the changes in the proband’s gDNA sequence (DECIPHER #430183). Intragenic MED13L deletion was specified via quantitative polymerase chain reaction (qPCR) and Sanger sequencing of the proband’s cDNA sample. Western blot and bioinformatics analyses were used to investigate the consequences of this copy number variant (CNV) at the protein level. CRISPR-Cas9 technology was used for a MED13L-gene-silencing experiment in a culture of the control individual’s skin fibroblasts. After the MED13L-gene-editing experiment, subsequent functional fibroblast culture analyses were performed. Results: The analysis of the proband’s cDNA sample allowed for specifying the regions of the breakpoints and identifying the heterozygous deletion that spanned exons 3 to 10 of MED13L, which has not been reported previously. In silico, the deletion was predicted to result in a truncated protein NP_056150.1:p.(Val104Glyfs*5), partly altering the Med13_N domain and losing the MedPIWI and Med13_C domains. After MED13L gene editing was performed, reduced cell viability; an accelerated aging process; and inhibition of the RB1, E2F1, and CCNC gene expression were found to exist. Conclusions: Based on these findings, heterozygous intragenic 12q24.21 deletion in the affected individual resulted in MED13L haploinsufficiency due to the premature termination of protein translation, therefore leading to MED13L haploinsufficiency syndrome.
Onco-TESE (Testicular Sperm Extraction): Insights from a Tertiary Center and Comprehensive Literature Analysis
Authors: Cirigliano Lorenzo , Falcone Marco , Gül Murat , Preto Mirko , Ceruti Carlo , Plamadeala Natalia , Peretti Federica , Ferro Ilaria , Scavone Martina , Gontero Paolo
Published: June 2023

Background and Objectives: The peak of incidence of testicular cancer (TC) occurs among individuals in their reproductive age, emphasizing the importance of fertility preservation as an integral aspect of disease management. Sperm cryopreservation performed before orchiectomy is ineffective in azoospermic men, necessitating alternative approaches such as microdissection testicular sperm extraction (mTESE) at the time of orchiectomy (onco-mTESE) to obtain viable sperm. This study presents the findings from our institution’s experience with onco-mTESE and critically discusses our results in light of the existing body of literature. Materials and Methods: This is a tertiary center retrospective analysis of onco-mTESE procedures performed at a single center between December 2011 and July 2022. The included patients were post-puberal men with testicular tumors requiring orchiectomy, along with concomitant severe oligozoospermia or azoospermia. Bilateral mTESE was performed in all cases. Surgical outcomes, sperm retrieval rates, the usage of preserved viable sperm, assistive reproductive techniques’ results, and post-operative serum testosterone were recorded. Results: A total of nine patients were included, with a median age of 34 (IQR 29–36) years. All patients had germ cell tumors (GCTs), with seminomatous and non-seminomatous GCTs accounting for 44.4% (n = 4) and 55.6% (n = 5) of patients, respectively. Sperm retrieval occurred in three (33%) patients: one patient in the ipsilateral testis, one in the contralateral testis, and one in both testes. No complications were reported during the procedure, and no post-operative hypogonadism was observed. Among the three patients with successful sperm retrieval, an intracytoplasmic sperm injection (ICSI) was performed in two patients, resulting in two pregnancies, leading to one healthy live birth and one miscarriage. Conclusions: In the context of TC, it is essential to conduct a thorough evaluation of testicular function, including a semen analysis and cryopreservation. Onco-mTESE has proven its safety in preserving fertility in azoospermic cases while ensuring the efficacy of oncological treatment.
Phytobezoar-Induced Mechanical Ileus and Incipient Intussusception: A Case Report
Authors: Kosmidis Christoforos S. , Mystakidou Chrysi Maria , Varsamis Nikolaos , Koulouris Charilaos , Sevva Christina , Papadopoulou Konstantina , Michael Christina , Katsios Nikolaos Iason , Theodorou Vasiliki , Miltiadous Petrina , Papadopoulos Konstantinos , Vlassopoulos Konstantinos , Zarampouka Katerina , Mantalovas Stylianos
Published: June 2023

Phytobezoars constitute conglomerates of indigested plant fibers and are a rare cause of acute mechanical ileus. They exhibit an increased prevalence in the elderly population and people with specific predisposing conditions. Radiological imaging can often set a definitive diagnosis and dictate the optimal therapeutic approach, combined with the patient’s clinical status. An 81-year-old male presented with deteriorating clinical symptoms of intestinal obstruction, and an exploratory laparotomy was performed following inconclusive radiological findings; multiple phytobezoars and incipient intussusception were revealed intraoperatively. A patient’s medical history can often raise clinical suspicion of phytobezoars. However, a careful etiological investigation is imperative in all cases of mechanical ileus in advanced ages; early detection and dissolution of phytobezoars, when applicable, can reduce the need for surgical interventions.