bluuebunny/crossref_metadata_2025 huggingface dataset:
Muscle mass is an important prognostic factor for patients with lung cancer: a cross-sectional multicenter prospective cohort study
Authors: Shi Hanping , Wang Xin , Zhao Hong
Published: November 2024

Introduction:
Muscle dysfunction and loss of mass are significant clinical concerns and key features of cancer cachexia. However, the potential predictive role of muscle mass, especially hand grip strength (HGS), as a prognostic factor in lung cancer remains underexplored. The aim of this study is to determine whether HGS, as a measure of muscle mass, is an effective predictor of clinical outcomes in patients with lung cancer.
Methods
This research is a cross-sectional multicenter prospective cohort study, encompassing patients aged over 18 from 29 medical centers. These patients were diagnosed with lung cancer between June 2012 and December 2019. We assessed muscle mass using several indicators: hand grip strength (HGS), mid-arm circumference (MAC), left mid-arm muscle circumference (MAMC), mid-arm muscle area (MAMA), left maximum calf circumference (MCC), and an overall muscle wasting score (OMWS). These indicators serve to measure muscle strength and mass. The primary outcomes of this study are overall survival (OS) time and all-cause mortality. Hazard ratios (HRs) were applied to analyze the impact of muscle mass on the all-cause mortality.
Results
Totally 3496 patients from 29 medical centers were included. Patients were stratified into four groups based on the quartiles of their HGS scores, with group sizes of 874, 860, 887 and 875, respectively. Subgroup analysis revealed that patients with lower HGS scores had significantly poorer outcomes than those with higher scores. The 5-year survival probabilities were 30.73%, 35.43%, 31.04 and 39.06% for each group respectively (p < 0.0001), even after adjusting for tumor stage and gender. Univariate Cox regression analysis revealed that higher HGS was an independent protective factor for patients with lung cancer (hazard ratio = 0.69, 95% confidence interval [CI]: 0.59–0.81). Multivariable Cox proportional hazards regression analysis corroborated this finding. Other muscle mass metrics, such as MAC, MAMC, MAMA, MLC and OMWS, also underscore the protective role of maintaining muscle mass in lung cancer prognosis.
Conclusions
The progressive and widespread reduction of skeletal muscle mass and strength is a critical negative prognostic indicator in lung cancer patients. Among all the evaluated parameters, HGS demonstrates the most significant correlation with overall survival. It stands out as a key factor in predicting the prognosis of patients with lung cancer.
Promoting sustainable food purchases in online grocery shopping: insights from a pilot randomised controlled field trial
Authors: Bentil Helena , Oyebode Oyinlola , Scarborough Peter , Thompson Claire , Brock Jessica , Clark Michael , White Martin , Rens Thijs Van
Published: November 2024

Objective
It remains unclear which interventions are effective in promoting more sustainable (or healthier) food choices within online grocery shopping environments.
We set out to 1) use a plug-in (browser extension) to implement a pilot randomised controlled trial of eco-labels for specific food products to promote more sustainable purchasing and collect food purchase data, and 2) collect data to inform a larger trial investigating the effectiveness of eco-labels and other interventions promoting environmentally sustainable online food purchases. The plug-in was custom-built and active on a large UK supermarket website, accessed using the Google Chrome browser on a desktop or laptop.
Results
Of 504 participants screened, 161 met eligibility criteria and were invited to participate in the study. 57 of these downloaded the plug-in, of which 22 shopped at least once over the 1-month trial. There was no significant difference in average eco-score of purchases between control and intervention groups (p= 0.22). 69/161 eligible participants responded to an endline survey and suggested technical support, reminders, greater incentives, and more information about eco-labels were needed for the full trial. We showed that it is feasible to evaluate online grocery shopping interventions without the collaboration of a supermarket using a web browser extension.
Community-associated methicillin-resistant Staphylococcus aureus infection of diabetic foot ulcers in an eastern diabetic foot center in China: A whole-genome-based study
Authors: Chen Yixin , Ji Jingshu , Lei Yongzhen , Zhu Weifen , Wang Chiyu , Yang Jie , Wang Ying , You Jiaxing , Liu Chao , Li Hong , Li Lin
Published: November 2024

Background
Diabetic foot infections are an important cause of hospitalization and disability in patients with diabetes. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is commonly linked to skin and soft tissue infections and is prevalent in diabetic foot wounds. This study aimed to investigate the clinical features of methicillin-resistant Staphylococcus aureus (MRSA) infections in diabetic foot ulcers and characterize the genetic profiles of MRSA strains.
Results
Sixteen Staphylococcus aureus strains were collected from 16 diabetic foot infections, including 10 MRSA and 6 methicillin-sensitive Staphylococcus aureus (MSSA) from severe cases. Through next-generation sequencing, nine of the ten MRSA strains were genetically identified as CA-MRSA clones. Six of the nine CA-MRSA clones were associated with severe infections. There was no significant difference in the number of virulence or drug-resistance genes between the MRSA and MSSA strains. ST59-IVa was the most commonly isolated MRSA strain (40%, 4/10), with three of the four strains (75%) being the Asia-Pacific clone ST59-t437-IVa. All four ST59 strains carried the chp and seb genes; in contrast, three of the ST59 strains carried the pvl gene.
Conclusion
In our center, CA-MRSA clones were the most common cause of MRSA infections in diabetic foot ulcers, with ST59-IV being the predominant clone. The combination of drug resistance and high virulence in CA-MRSA poses a significant threat to patients with diabetes and foot ulcers.
DCE-MRI detects OATP-expressing transplanted cells using clinical doses of gadolinium contrast agent
Authors: Bhattacharyya Tapas , Mallett Christiane L. , Hix Jeremy M.-L. , Shaprio Erik
Published: November 2024

Purpose
Hepatic organic anion transporting polypeptides (OATPs) transport off-the-shelf, FDA-approved, hepatospecific Gd-based MRI contrast agents into cells that express the transporters enhancing signal on T1-weighted MRI. Studies have used MRI to identify OATP-overexpressing tumors and metastases transplanted in mice following the delivery of Gd-EOB-DTPA at 27-67-fold higher than clinical doses. With safety and regulatory concern over Gd-based contrast agents, translating OATPs as an MRI reporter protein to humans for regenerative medicine will require substantially lower doses of agent.
Procedures:
We engineered the MyC-CaP mouse tumor cell line to express rat OATP1B2, which influxes both Gd-EOB-DTPA and Gd-BOPTA, resulting in signal enhancement on T1-weighted MRI. We then inoculated mice with rat OATP1B2 and non-expressing cells bilaterally to generate tumors. 3–4 weeks after inoculation, when tumors had formed, in-vivo MRI imaging was performed with delivery of 0.025 mmol/kg or 0.25 mmol/kg of the Gd-based contrast agents. We complemented static T1-weighted MRI and T1-mapping with dynamic contrast enhanced (DCE)-MRI and performed area under the curve (AUC) analysis to discriminate the two tumor types.
Results
While all OATP1B2-expressing tumors were easily visible at the high dose of 0.25 mmol/kg on T1-weighted MRI and easy to distinguish from control tumors, OATP1B2-expressing tumors were hard to identify and distinguish from non-expressing tumors at the lower, clinical dose of 0.025 mmol/kg with standard T1-weighted MRI or T1-mapping. However, AUC analyses of the DCE-MRI curves could identify and distinguish these tumors, needing 30 (Gd-EOB-DTPA) or 45 (Gd-BOPTA) minutes acquisition time.
Conclusions
By performing AUC analyses of DCE-MRI curves following delivery of clinical concentration of MRI contrast agents, OATP1B2-expressing tumors could be identified and distinguished from control tumors, suggesting this imaging approach as a path to substantially reducing the amount of contrast agent needed to use OATPs as a clinically viable reporter protein for imaging regenerative medicine.
Evaluation of Mandibular and Maxillary Second Molar Root Canal Anatomy in a Turkish Subpopulation Using CBCT: Comparison of Briseno-Marroquin and Vertucci Classifications
Authors: GÜNEÇ Hüseyin Gürkan , ÖREROĞLU İpek , ÇAĞLAR Kemal , AYDIN Kader CESUR
Published: November 2024

Background
This retrospective study aims to characterise the root canal morphology of maxillary and mandibular molars using cone-beam computed tomography (CBCT). The number of roots and canal configurations were evaluated using both the Vertucci and Benjamı´n Brisen˜ o Marroquı´n classification systems.
Methods
Total of 1084 second molar images (523 upper; 266 right and 257 left sides & 561 lower; 285 right and 276 left sides) were obtained from 320 CBCT scans that were analysed. CBCT imaging provided superior visualisation of root canal anatomy compared to periapical radiography. The findings revealed diverse root canal configurations, with variations observed even within the same population. Statistical analyses, including the chi-squared test, were used to assess correlations between root number and demographic variables such as age and sex.
Results
According to Benjamı´n Brisen˜ o Marroquı´n classification system, the most common configuration for upper right three-rooted teeth mesial root was 3172−1 (n:66, 35.7%), for distal root was 3171 (n:169, 91.4%), and for palatal root was 3171 (n:165, 89.2%). Additionally, the most common configuration for upper left three-rooted teeth mesial root was 3271 (n:50, 28.4%), for distal root was 3271 (n:160, 90.9%), and for palatal root was 3271 (n:158, 89.8%). In lower left molars, the most common configuration in the two-rooted teeth mesial root was 2372 (n:114, 49.4%), and for the distal root was 2371 (n:170, 73.6%). For lower right the most common configuration for two-rooted teeth mesial root was 2472 (n:125, 52.5%), and for distal root was 2471 (n:173, 72.7%)( p < 0.05).
Conclusion
Due to highly variable morphological features observed in the upper- and lower-second molars of the Turkish subpopulation, CBCT is strongly recommended on a case-by-case basis. The results revealed extensive variations in root canal morphology.
Health-related quality of life and associated factors among individuals with heart failure attending public hospitals in Nekemte town, Western Oromia, Ethiopia: A cross-sectional study
Authors: Dinku Kidane , Chala Dereje , Regea Firaol , Lema Matiyos
Published: November 2024

Background:Heart failure has a significant impact on patients' health-related quality of life. Despite the potential importance of assessing the health-related quality of life among people with heart failure, only two studies have been conducted in Ethiopia, which may limit the generalizability of the findings in Ethiopia. Therefore, this study assessed the health-related quality of life and associated factors among people with heart failure attending public hospitals in Nekemte town, western Ethiopia.
Methods: A hospital-based cross-sectional study was conducted from May 20 to August 20, 2023; a random sampling method was used to enroll the 422 participants. Health-related quality of life was assessed using the Minnesota Living with Heart Failure Questionnaires standard tool. Data was coded and entered using Epi-Data version 4.6 and exported to SPSS software version 26 for cleaning and analysis. Bivariate and multivariable logistic regressions were used to determine the factors influencing health-related quality of life among people with heart failure. A P value ≤ 0.05 was considered statistically significant in this study.
Results:A total of 422 people with heart failure participated, (51.2%), 95% CI: (47.15–52.36) have poor health-related quality of life. More than half of the people with heart failure who participated in this study had poor health-related quality of life (51.2%), 95% CI: (47.15–52.36). Rural residency AOR=3.34, 95% CI (1.82, 6.13), lack of formal education AOR=2.92, 95% CI (1.17, 7.32), NYHA classes III and IV AOR=3.76, 95% CI (2.03, 6.96) and 4.91 (2.45, 9.90), respectively, longer duration with heart failure AOR=3.52, 95% CI (1.22, 10.13), and with other comorbid illnesses AOR=2.89, 95% CI (1.40, 5.97) were associated with poor health-related quality of life among people with heart failure.
Conclusions: This study indicates that more than half of the participants had poor health-related quality of life among people with heart failure.It is associated with rural residency, lack of formal education, higher NYHA classes, longer duration, and comorbid illnesses. So, clinicians should consider and improve the quality of life by addressing the factors associated with heart failure. Future studies are warranted to examine the causal relationship between quality of life and associated factors among people with heart failure.
Atypical Pulmonary Manifestations Suggestive of Lung Cancer in Behçet’s Disease with Spontaneously Regressing Lymphadenopathy and a Lung Mass: A Case Report
Authors: Kim So-yun , Yeo Min-kyung , Im Subin , Chung Chaeuk
Published: November 2024

Background
Behçet’s disease (BD) is a multisystem inflammatory disorder that can affect various organs, including the lungs. Pulmonary manifestations are rare and typically present as pulmonary artery aneurysms.
Case presentation
We report the case of a 56-year-old East Asian male with a 27-year history of BD, who had no respiratory symptoms, such as hemoptysis, cough, or fever. Chest imaging revealed lymph node enlargement and a lung mass, initially raising concerns of malignancy. Despite the suspicious radiological findings, three biopsies, including a surgical biopsy, were all negative for malignancy. Remarkably, over the course of 2 years, these pulmonary manifestations spontaneously regressed without any specific treatment for lung involvement, and the patient remained in a stable BD state.
Conclusions
BD patients are at an increased risk for malignancy compared to healthy controls, making it crucial to differentiate between malignancy and BD-related pulmonary abnormalities. This case highlights that, in the absence of active BD symptoms, lymphadenopathy and lung masses can occur and may resolve spontaneously. Accurate diagnosis and vigilant monitoring are essential in BD patients but BD-related lung involvement should be considered in similar cases.
3-Hydroxybutyrate, A Metabolite in Sustaining Neuronal Cell Vitality: A Mendelian Randomization and in Vitro Experimentation
Authors: Hu Xiaoling , Lin Yu , Huang Kaiwen , Xu HuiLin , Fu Changmei Huang , Ou Jiayin , Fan Xiude , Li Zhe , Fang Jiansong , Fang Shuhuan
Published: November 2024

Background Recent research has implicated mitochondrial DNA copy number (mtDNA-CN) and Tau protein levels in the blood as potential biomarkers for early Alzheimer's disease (AD) risk assessment, correlating with metabolite profiles. However, intermediary metabolites mediating these associations remain elusive.
Methods Employing a two-sample and a mediation Mendelian randomization (MR) analysis of the IEU OpenGWAS database, involving 383,476 participants from a genome-wide association study (GWAS) and an exome-wide association study (ExWAS), we identified intermediary metabolites linking mtDNA-CN and Tau.Meanwhile, the effects of mediating metabolites on HT22 cell viability and its mitochondrial morphology were also assessed in conjunction with in vitro experiments.
Results Our study revealed an association of mtDNA-CN on Tau (OR = 3.102, 95% CI: 1.016-9.472, P = 0.047), as well as on other 31 metabolites such as 3-Hydroxybutyrate (3HB), Docosahexaenoic acid (DHA), Acetate, Albumin, Apolipoprotein A-I (APOA1), and so on. Notably, 3HB was further implicated in a relationship with Tau (OR = 6.030, 95% CI: 1.054-34.491, P = 0.043), acting as a mediator between mtDNA-CN and Tau. In vitro experiments demonstrated that 3HB positively sustained HT22 cell viability by MTT assay and mitigated mitochondrial swelling under low glucose conditions, as observed via HIS-SIM.
Conclusions These findings underscore the potential of 3HB as a biomarker and mediator in early AD risk assessment. Moreover, 3HB's ability to enhance cell viability and preserve mitochondrial morphology in stressed conditions suggests its therapeutic potential in mitigating energy metabolism imbalances in AD brains.
2mg baricitinib may have fewer adverse reactions than we thought: A meta-analysis
Authors: Ou Zuzhen , Huang Hui , He Xu , Chen Shiqi , Wang Yuqing , Wang Caifeng , Liu Nian , Yin Rui , Liu Shulei
Published: November 2024

Background: Baricitinib, an oral selective inhibitor of Janus kinase 1 (JAK 1) and JAK 2, has been reported to perform amazingly in patients with moderate-to-severe atopic dermatitis (AD), but its adverse reactions are still contentious.
Objective: This study is design to evaluate the adverse reactions to 2 mg baricitinib in the treatment of patients suffering from moderate-to-severe AD.
Method: Trials involving adverse reactions of baricitinib in treatment of patients with moderate-to-severe AD were searched in the MEDLINE, Cochrane databases, EMBASE and Web of Science, and on ClinicalTrials.gov. The outcome of the research was the incidence of adverse events during the experimental period.
Results: Seven RCTs were brought into this study. Meta-analysis found that patients treated with 2 mg baricitinib suffered a higher risk of headache (RR 1.54, 95% CI 1.05–2.26, P = 0.03), while almost no difference was found in the incidence of other adverse events between the baricitinib and placebo groups.
Conclusion: Baricitinib (2 mg) had a higher risk of headache when treat patients with moderate-to-severe AD, but had little influence on other adverse events, such as skin infectious events and non-skin infectious events.
Long-term outcomes of Fistula Laser Closure (FiLaC ® ) with a 1470 nm diode laser for cryptoglandular anal fistula
Authors: Zhu Jingyi , Li Zhicheng , Jin Lei , Zhang Xiyue , Wu Jiong , Wang Zhenyi
Published: November 2024

Objective
The aim of this study was to evaluate the long-term efficacy of Fistula Laser Closure (FiLaC®)with using a 1470 nm diode laser in the treatment of cryptoglandular anal fistula.
Methods
Data of patients with cryptoglandular anal fistula who underwent FiLaC® in our department between September 2017 and December 2019 were retrospectively analyzed. Demographic data, perioperative data and postoperative data were collected and statistically analyzed.
Results
A total of 52 patients who met the inclusion criteria were included in the study. The cure rates at 1month, 1 year, and 5 years were 96.2% (50/52), 82.7% (43/52), and 76.9% (40/52), respectively. The differences among the internal opening position subgroups were statistically significant (P = 0.018), with the bilateral type having a higher cure rate than the anterior and posterior types (86.2%, 75% and 37.5%, respectively). No statistically significant differences were observed between the subgroups: Parks classification, number of internal openings, closure of internal openings, treatment of internal openings, number of external openings, relative position of internal and external openings, presence of straight fistula, and presence of blind fistula. All the scores, including visual analogue scale pain score (VAS-PS), cleveland clinic florida incontinence score (CCF-IS), and the quality of life in patients with anal fistula questionnaire score (QoLAF-QS), showed a gradual increase over time, followed by a subsequent decrease.
Discussion
Although the cure rate of the FiLaC® technique is inferior to that of traditional surgery, the FiLaC® technique has significant advantages in reducing the postoperative pain, the risk of fecal incontinence, and the postoperative quality of life. Furthermore, the FiLaC® technique is more suitable for cryptoglandular anal fistulas with an internal opening located on both sides or behind the anal canal. This study provides a preliminary evaluation of the FiLaC® technique, and we hope to increase the cure rate in the future by observing improvements in surgical methods, laser burning power, laser burning time and other aspects.
Stereotactic body radiotherapy (SBRT) as a treatment for localized prostate cancer: a retrospective analysis
Authors: De Cooman Brecht , Debacker Tibaut , Adams Thomas , Lamberts Guy , De Troyer Bart , Claessens Marc , De Kerf Geert , Mercier Carole , Dirix Piet , Ost Piet
Published: November 2024

Background
External beam radiotherapy (EBRT) is a standard treatment for localized prostate cancer, with recent advancements favoring a reduced number of treatment sessions. Stereotactic body radiotherapy (SBRT) is a form of radiotherapy that delivers higher doses per fraction, typically in five or fewer sessions. This retrospective study aims to evaluate the implementation of the PACE-B SBRT protocol for localized prostate cancer at our center by assessing the incidence and severity of toxicity, as well as biochemical relapse-free survival.
Methods
We conducted a retrospective analysis of patients with localized prostate cancer treated with SBRT at the Iridium Network in Antwerp, Belgium, who were treated between January 1, 2020, and December 31, 2022. Data were extracted from electronic medical records and included descriptive information on patient outcomes. Acute and late genitourinary (GU) and gastrointestinal (GI) toxicities were graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Acute toxicity was defined as events occurring within 90 days post-SBRT, whereas late toxicity was evaluated at 6 months, 1 year, 2 years, and 3 years post treatment. Biochemical recurrence was defined via the Phoenix criteria, as a rise in PSA levels of 2 ng/mL or more above the post treatment nadir.
Results
A total of 267 patients met the eligibility criteria for this study. In total, 9% of patients were low risk, 51% were intermediate risk, and 40% were high risk. The cumulative incidence of Grade 2 or higher GU toxicity was 27%, and for GI toxicity, it was 2%. At 24 months, 11.5% (20/175) of patients experienced CTCAE grade 2 or higher GU toxicity, and 1.7% (3/175) experienced grade 2 or higher GI toxicity. Biochemical relapse occurred in 1.5% (4/267) of patients, leading to a 3-year biochemical relapse-free survival rate of 98.5%.
Conclusion
SBRT for localized prostate cancer has favorable oncological outcomes with a low incidence of Grade 2 or higher toxicity. The results of this study are consistent with findings from prospective trials, suggesting that SBRT is an effective treatment modality.
Trial registration
Retrospectively registered.
The use of a heated helium-oxygen mixture in patients with severe COVID-19 and ARDS against the background of standard therapy and noninvasive ventilation
Authors: Nuralieva G. S. , Shmidt A. E. , Yaroshetskiy A. I. , Nekludova G. V. , Gaynitdinova V. V. , Tsareva N. A. , Merzhoeva Z. M. , Chikina S. Yu. , Trushenko N. V. , Avdeev I. S. , Avdeev S. N.
Published: November 2024

Introduction. One of the insufficiently studied methods of Acute Respiratory Distress Syndrome (ARDS) therapy is therapy with a heated helium-oxygen mixture. Due to physico-chemical properties, helium demonstrates high efficiency in the treatment of various diseases of the pulmonological profile.

Aim. To study the effect of a heated helium-oxygen mixture on the course of a severe form of COVID-19 occurring with the development of ARDS.

Materials and methods. The study involved 58 patients with severe and extremely severe coronavirus infection and ARDS, divided into the NVL + t-He/O2 group (n = 30) and the NVL+O2 control group (n = 28). In addition to standard treatment, patients of the NVL + t-He/O2 group received noninvasive ventilation (NVL) and therapy with a heated helium-oxygen mixture, according to clinical recommendations. In the main group, inhalations took place daily for 60 minutes per day for 5 days.

Results. Against the background of therapy with a heated helium-oxygen mixture, a more intense increase in the level of lymphocytes was observed: 1.39 (1.09-1.66) x 109/l in the NVL + t-He/O2 group versus 1.02 (0.78-1.40) x 109/l (p = 0.02). Also, as a result of treatment, there was a significant decrease in RR, D-dimer and CRP in the study group: the level of RR (21 (20-22)/minute versus 22.5 (21-24)/minute, p = 0.003), D-dimer (0.44 (0.29-0.60) FEU ng/ml versus 0.79 (0.42-1.34) FEU ng/ml, p = 0.02) and CRP (1.1 (0.7-3.1)mg/l versus 16.6 (8.5-29.5) mg/l, p = 0.03), respectively. Similarly to the NVL + t-He/O2 group, an increase in the level of PaO2 and the oxygenation index was noted. In addition, there were significantly fewer patients with grade III and IV lung damage in the NVL + t-He/O2 group compared with the control (p = 0.05).

Conclusion. The use of a heated helium-oxygen mixture in patients with severe COVID-19, occurring with the development of ARDS, against the background of standard therapy and NIV has shown its safety and effectiveness: there was a decrease in the intensity of inflammation, improved oxygenation and a reduction in the need for respiratory support.
Clinical assessment of patient outcomes post percutaneous pulmonary valve implantation: Insights from a single tertiary centre
Authors: Saluja Sushant , Myers Daniel , Keavney Bernard , Keshavarzi Freidoon , Anderson Simon
Published: November 2024

Background: Percutaneous pulmonary valve implantation (PPVI) has emerged as a promising treatment for congenital right ventricular outflow tract (RVOT) dysfunction and restoring conduit graft viability.
Methods: This is a single-centre retrospective study of 41 patients (18 men, 23 women; mean age 26.1±10.2 years) who underwent PPVI between December 2007 and November 2014 and were evaluated for right ventricular pressures and exercise tolerance.
Results: PPVI significantly reduced mean baseline RVOT gradients across different pathologies: stenosis (45 vs 18.4 mmHg), regurgitation (19.2 vs 7.6 mmHg), and mixed disease (32.5 vs 12 mmHg). Furthermore, mean right ventricular (RV) systolic pressures decreased from 61.6±2.3 to 41.9±2 mmHg (p<0.001), while RV diastolic pressures decreased by about 60% from 14.3±1.1 to 8.6±1.4 mmHg (p<0.001). Echocardiography revealed significant improvements in pulmonary and tricuspid valve velocities (p for trend<0.01). Additionally, there was a consistent reduction in the main pulmonary artery maximum pressure gradient measured pre-procedure. No significant changes were observed in PR, QRS, or QTc interval duration on follow-up electrocardiograms. Similarly, no changes were noted in cardiopulmonary exercise test performance during follow-up.

Conclusion: The study highlights the effectiveness of PPVI using Medtronic Melody and Edwards SAPIEN valves in patients with various pulmonary diseases. Immediate improvements in right ventricular pressures and functional outcomes suggest that PPVI is a valuable treatment option for individuals with RVOT dysfunction. Multi-centre collaborations are crucial for further elucidating the long-term effects of PPVI on cardiac function, exercise tolerance, and quality of life in RVOT dysfunction.
Heartfelt struggles: When ablation brings the squeeze
Authors: Al Hennawi Hussam , Shpilman Alexander
Published: November 2024

Pericarditis frequently occurs as a complication following pulmonary vein isolation (PVI) for atrial fibrillation (AF), yet it seldom progresses to constrictive pericarditis (CP). The diagnosis of constrictive pericarditis is often challenging owing to nonspecific signs and symptoms. Nevertheless, a high level of suspicion and prompt diagnosis offer an ultimate cure. We present a case of a 65-year-old patient who developed chronic pericarditis following PVI. This instance underscores the importance of promptly identifying this complication within this particular group of patients.
Capacitación por competencias para la equidad de género en estudiantes de la Universidad Nacional de Educación (Ecuador). Estudio comparativo
Authors: Seade-Mejía Carolina , Acosta-Altamirano María-Fernanda , Rosado-Holguín Giovanna-Rosalía
Published: November 2024

La presente investigación está enfocada en la capacitación por competencias para la equidad de género en estudiantes de la Universidad Nacional de Educación, pues este es un gran problema a nivel social. Se destaca la necesidad de promover la igualdad de género como un derecho humano fundamental. Por lo que el objetivo del estudio es visibilizar los resultados de la implementación de una capacitación por competencias sobre conceptos de género, sexo, equidad, violencia y derechos de género, destinada a los estudiantes de la Universidad Nacional de Educación. Con un enfoque cuantitativo a través de la implementación de un estudio pre-test/post-test, con la capacitación de por medio. Los resultados reflejan mejoras estadísticamente significativas en todas las dimensiones del cuestionario aplicado, tras la capacitación. Se visibiliza la necesidad de implementar este tipo de espacios formativos a toda la comunidad universitaria con el fin de erradicar las prácticas que perpetúan las inequidades de género.
Safahat ve Buhranlarımız Adlı Eserlerin İslamcılık Göstergeleri Bakımından Karşılaştırılması
Authors: Kurt Ömer
Published: November 2024

Osmanlı İmparatorluğu’nun Dağılıp Parçalanma Dönemi’nde içinde bulunulan kötü durumdan çıkış için aydınlar tarafından birçok kurtuluş reçetesi ortaya atılmıştır. Bu reçetelerden birisi de İslâmcılık fikridir. Buna göre birçok milliyeti içinde barındıran devleti bölünmekten kurtaracak yegâne çözüm, Hz. Muhammed’in Veda Hutbesi’nde özellikle vurguladığı İslâm kardeşliği çatısı altında sımsıkı kenetlenmek ve Garp’ın taarruzlarına karşı birlik olmaktır. Bu aydınlar oldukça realist bir bakış açısıyla Adriyatik’ten Çin ve Hindistan’a uzanan geniş coğrafyada İslâm dünyasının içinde bulunduğu geri kalmışlığı kabul etmiş ve bundan çıkış yolunu aramışlardır. Bu aydınlar arasında Osmanlı İmparatorluğu’na Sadrazam olarak görev yapmış Kavalalı Mehmet Ali Paşa’nın torunu Sait Halim Paşa ile İstiklâl Marşı’nı yazan Mehmet Âkif Ersoy bulunmaktadır. Sait Halim Buhranlarımız adlı eserinde görüşlerini derli toplu olarak yazıya dökerken Âkif Safahat adlı eserinde yer alan şiirlerinin fikrî arka planında söyleyeceklerini ifade etmiştir. Her iki isim de eserleri ayrıntılı incelendiğinde manevi vatan, edebiyatta muhit, şuursuz Batı taklitçiliği, hurafelerle örülmüş ve gelenekselleşmiş din, İslâm’ın özüne ters olan ırkçılık ile Batı’yı örnek almadan kendi ayakları üzerine yükselen bir medeniyetmiş gibi algıladıkları Japon medeniyeti gibi konularda birbirine çok yakın sayılabilecek savlar ileri sürmüşlerdir.
Sensitive HPLC Method to Support Pre-formulation Studies and to Determine Critical Quality Attributes of Therapeutic Contact Lenses Containing Dorzolamide Hydrochloride
Authors: Jani Harshilkumar , Ranch Ketan , Lalwani Rahul , Patel Yashkumar , Bodiwala Kunjan , Gajjar Anuradha
Published: November 2024

Background:

Dorzolamide hydrochloride (DRZ) is a carbonic anhydrase inhibitor used
to treat glaucoma and ocular hypertension. Drug-eluting contact lenses, such as Acuvue Theravision
™ with Ketotifen, offer improved drug delivery and reduced side effects compared to eye
drops. Drug-loaded nanoparticle-loaded contact lenses can sustain drug release and enhance comfort
for extended wear.

Objective:

High buffer concentration and low pH increase the risk of damage to silica-bonded
columns. Therapeutic contact lenses face challenges related to critical lens parameters, including
the estimation of drug incorporation and release due to interference of lens matrix leaching. There
is currently no analytical method available for estimating DRZ in contact lenses.

Methods:

The HPLC method, which was developed and validated using ICH Q2 (R1) criteria,
used a C18 column (250 mm × 4.6 mm, 5 μm) as a stationary phase and methanol:water (70:30
v/v) as the mobile phase. The detecting wavelength was 253 nm. Moreover, to support the efficiency
of the developed method, the marketed formulation of DRZ eye drops, drug purity, and loading
in contact lenses were analysed. The method was also employed to determine the Critical Quality
Attributes (CQAs) of therapeutic contact lenses and drug release and drug leaching during the sterilization
process.

Results:

The developed HPLC method shows Rt for DRZ at 2.881 minutes with good linearity (r2
> 0.998) between 2-32μg/mL, precision (RSD < 2%), accuracy (Recovery > 99.5%), sensitivity,
and specificity for quantifying DRZ in marketed formulations and therapeutic contact lenses. The
developed method is devoid of any buffer or modifier in the mobile phase, making it safer for the
stationary phase. This method mitigates the interference of lens matrix leaching, which induces an
overestimation of DRZ. All the result for therapeutic contact lenses was found to be closely
aligned with theoretically expected results, confirming the reliability of the developed HPLC
method for therapeutic contact lenses.

Conclusion:

This method is specific, accurate, and precise for quantifying DRZ in commercial formulations
and newly developed therapeutic contact lenses. It effectively evaluates the critical quality
attributes of these lenses, demonstrating their reliability for assessing their performance and ensuring
quality in therapeutic applications.
The role of voluntary green behavior and green performance in promoting sustainability in the hospitality industry
Authors:   Faculty of Agriculture, University of Medan Area, North Sumatera, Indonesia, Lubis Yusniar , Hernosa Siswa Panjang ,   Faculty of Agriculture, University of Medan Area, North Sumatera, Indonesia, Sofiyan Sofiyan ,   Faculty of Economics, University of Prima Indonesia, North Sumatera, Indonesia, Lubis Fajar Rezeki Ananda ,   Faculty of Economics, University of Prima Indonesia, North Sumatera, Indonesia, Syaifuddin Syaifuddin ,   Faculty of Economics, University of Prima Indonesia, North Sumatera, Indonesia, Nasib Nasib ,   Department of Management, Business Institute of Information Technology and Business, North Sumatera, Indonesia
Published: November 2024

This study aims to explore how green training, green commitment, and green information management affect green performance in 5-star hotels in Medan City, focusing specifically on voluntary green behavior. The study's participants included 331 employees from seven 5-star hotels in Medan City: JW Marriott Hotel, Aryaduta Hotel, Grand Mercure, Cambridge Hotel, Grand City Hall Medan, Hotel Danau Toba International, and Adimulia Hotel. Each of these hotels has been in operation for more than five years. Data was collected through a questionnaire and analyzed using structural equation modeling (SEM). The findings confirm that green training, green commitment, and green knowledge management play important roles in promoting sustainable practices in the hotel industry. Investing in employee training to build knowledge and skills, showing strong management commitment to sustainability, and implementing effective knowledge management are key to creating a work environment that supports sustainability and environmental responsibility. The managerial implications suggest that hotels should focus on developing policies and programs that encourage sustainable practices. This includes improving education and training, strengthening organizational commitment, and adopting effective knowledge management practices. By doing so, hotels can enhance their sustainability performance and strengthen their reputation and competitiveness in an increasingly eco-conscious market.
Influence of Training With Corrective Feedback Devices on Cardiopulmonary Resuscitation Skills Acquisition and Retention: Systematic Review and Meta-Analysis
Authors: Nicolau Abel , Jorge Inês , Vieira-Marques Pedro , Sa-Couto Carla
Published: November 2024

Background

Several studies related to the use of corrective feedback devices in cardiopulmonary resuscitation training, with different populations, training methodologies, and equipment, present distinct results regarding the influence of this technology.

Objective

This systematic review and meta-analysis aimed to examine the impact of corrective feedback devices in cardiopulmonary resuscitation skills acquisition and retention for laypeople and health care professionals. Training duration was also studied.

Methods

The search was conducted in PubMed, Web of Science, and Scopus from January 2015 to December 2023. Eligible randomized controlled trials compared technology-based training incorporating corrective feedback with standard training. Outcomes of interest were the quality of chest compression–related components. The risk of bias was assessed using the Cochrane tool. A meta-analysis was used to explore the heterogeneity of the selected studies.

Results

In total, 20 studies were included. Overall, it was reported that corrective feedback devices used during training had a positive impact on both skills acquisition and retention. Medium to high heterogeneity was observed.

Conclusions

This systematic review and meta-analysis suggest that corrective feedback devices enhance skills acquisition and retention over time. Considering the medium to high heterogeneity observed, these findings should be interpreted with caution. More standardized, high-quality studies are needed.

Trial Registration

PROSPERO CRD42021240953; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=240953
Navigating Awareness and Strategies to Support Dementia Advocacy on Social Media During World Alzheimer’s Month: Infodemiology Study
Authors: Bacsu Juanita-Dawne , Fraser Sarah Anne , Jamali Ali Akbar , Conanan Christine , Chasteen Alison L , Vellani Shirin , Gowda-Sookochoff Rory , Berger Corinne , Mah Jasmine C , Fehr Florriann , Virani Anila , Rahemi Zahra , Nanson Kate , Cammer Allison , Andrew Melissa K , Grewal Karl S , McGilton Katherine S , Lautrup Samantha , Spiteri Raymond J
Published: November 2024

Background

Understanding advocacy strategies is essential to improving dementia awareness, reducing stigma, supporting cognitive health promotion, and influencing policy to support people living with dementia. However, there is a dearth of evidence-based research on advocacy strategies used to support dementia awareness.

Objective

This study aimed to use posts from X (formerly known as Twitter) to understand dementia advocacy strategies during World Alzheimer’s Awareness Month in September 2022.

Methods

Posts were scraped from X during World Alzheimer’s Awareness Month from September 1, 2022, to September 30, 2022. After applying filters, 1981 relevant posts were analyzed using thematic analysis, and measures were taken to support trustworthiness and rigor.

Results

Our study revealed a variety of advocacy strategies, including sharing the voices of lived experience, targeting ethnic and cultural groups, myth-busting strategies, and political lobbying. Although a range of strategies were identified, further research is needed to examine advocacy strategies within different countries and political contexts. Furthermore, the impact of specific strategies on stigma reduction, cognitive health promotion, and policy change needs to be scientifically evaluated.

Conclusions

Our study offers valuable insight into strategies to bolster dementia advocacy and awareness campaigns to support people living with dementia. Findings from our research may provide critical insight for policymakers, organizations, and health professionals working to reduce dementia-related stigma and increase the uptake of risk-reduction activities to support the promotion of cognitive health.
Tele-exercise During the Confinement of the COVID-19 Pandemic Could Prevent Psychological Disorders in Community-Dwelling Older Mexican. An Exploratory Study (Preprint)
Authors: Ramírez-Arellano Otilia Aurora , Sánchez-Nieto José Miguel , Correa-Muñoz Elsa , Vaquero‑Barbosa Nayeli , Mendoza-Núñez Víctor Manuel
Published: November 2024

BACKGROUND

The confinement of older adults in the face of emerging situations such as the one experienced during the COVID-19 pandemic, represented a great challenge to continue with healthy aging programs at the community level, above all, because isolation is a risk factor for psychological disorders. One of the options to maintain these programs was the implementation of tele-gerontology.

OBJECTIVE

To determine the adherence and effect of tele-training in physical exercise during the confinement of the COVID-19 pandemic, on depression, anxiety, well-being and quality of life in a sample of older adults Mexicans.

METHODS

A exploratory quasi-experimental study was carried out in a convenience sample of 32 older adults. Two groups were formed: (i) Tai Chi Group n= 16; (ii) Strength Exercise Group n= 16. All were trained in the use of computers and smartphones, to use Zoom, WhatsApp. Their health status was evaluated to perform physical exercise and the following instruments were applied: (i) DASS-21 for depression and anxiety, (ii) WHOQOL-OLD for quality of life, (iii) PANAS for subjective well-being and (iv) Athens Insomnia Scale to detect insomnia, before and after supervised tele-exercise for six months.

RESULTS

Participant adherence to the tele-training physical exercise program was 90% in both groups. Likewise, the scores of the depression and anxiety, quality of life, subjective well-being and insomnia instruments did not show statistically significant differences (p>0.05) before and after the intervention in both groups.

CONCLUSIONS

Our findings suggest that tele-exercise could prevent psychological disturbances in emergent confinement situations such as that experienced during COVID-19.

CLINICALTRIAL

ISRCTN48485253
Comprehensive Towing Services Online
Authors: Tajne Ketan , Takale Abhijeet , Tale Mangesh , Patil Swaraj , Jha Swastik , Kanoje Swayam , Waikar Rahul
Published: November 2024

Abstract: This project aims to streamline and enhance the towing service experience through the development of a comprehensive web-based platform. Utilizing JavaScript, HTML, CSS, XAMPP, phpMyAdmin, and SQL, the platform offers a user-friendly interface that facilitates efficient towing services. JavaScript ensures dynamic client-side interactions, while HTML and CSS provide a clean and intuitive layout. XAMPP serves as the local server environment, and phpMyAdmin manages SQL database interactions. The backend, powered by SQL, securely handles user data, service requests, and provider details. Users can easily request towing services, track their status, and access service history, while providers can manage their fleet and respond to requests efficiently. This project represents a significant advancement in the towing service industry, offering a seamless solution that benefits both users and service providers through its robust technological foundation.
Dielectric Studies of Soil at Various Microwave Frequencies
Authors: Kumari Kamlesh , Vishu  , Gupta V. K.
Published: November 2024

Abstract: Dielectric constant (real and imaginary parts) of moist soils is calculated at microwave frequency with an empirical model. The model equation is generated by curve fitting experimental data with second order polynomial expression. Two types of sandy loam samples are used to estimation of dielectric constant at frequencies range from 4.0 GHz to 18.0 GHZ. Both soil samples (sandy loam) are differentiated according to their textural composition. The real part of dielectric constant is negatively corelated with microwave frequency while imaginary parts of soil increase as frequency increases.
AI-Powered Autonomous Trading: Enhancing Market Efficiency Through Predictive Analytics
Authors: Goyal Hemanshu , Chandel Nikhil , Maurya Abhishek , Shailja
Published: November 2024

Abstract: In the realm of financial markets, AI-powered autonomous trading systems are revolutionizing the way trades are executed and decisions are made. This paper presents a formal approach to developing an AI-powered trading system aimed at enhancing market efficiency through predictive analytics. The proposed system integrates machine learning algorithms, including deep learning and reinforcement learning, to analyze vast amounts of historical and real-time market data. Emphasis is placed on improving decision-making speed, accuracy, and risk management through techniques such as algorithmic trading, automated portfolio management, and sentiment analysis. The result is a robust, efficient, and scalable trading system that outperforms traditional models in terms of profitability, adaptability, and computational efficiency in high-frequency trading environments
Uses of Urban Sewer Water for Agriculture in Nanded City, Maharashtra, India
Authors: G Pawale R. , B Yannawar V.
Published: November 2024

Abstract: Estimating the effluent's quality is crucial for much wastewater research, as wastewater's chemical and physical characteristics influence its amount and usability. Field observations regarding the source or circumstances of wastewater occurring, the source of pollution, and other relevant factors that may impact wastewater quality are considered when assessing wastewater quality. The sustainability of wastewater for use is evaluated based on factors including pH, EC, TDS, hardness, total alkalinity, chloride, nitrate, sodium, and potassium. The assessment of sewer sustainability for irrigation is contingent upon its electrical conductivity and sodium content. These investigations were conducted in 2022 and 2023. Water samples gathered from industrial effluent, primarily used in farmlands and solely in the nearby areas, were examined in this study.
Implementing Football Prediction System Using Machine Learning
Authors: Bhatia Vedant , More Aditya
Published: November 2024

Abstract: The "Football Match Prediction System using Machine Learning" aims to predict football match outcomes using machine learning techniques. The project involves data preprocessing, feature engineering, and training various machine learning models, including Naive Bayes, Random Forest, and XGBoost. The results show the model can predict match outcomes with reasonable accuracy, providing valuable insights into match performance. Future work aims to refine the model by incorporating additional features like player data and external factors like weather conditions to further enhance prediction accuracy. The project aims to provide valuable insights into match performance. Impact Statement– The Football Match Prediction System is a data-driven tool that can revolutionize football match engagement by providing accurate predictions based on match outcomes. It aids team managers in strategy planning, informs betting markets, and enhances fan experience. The system integrates player statistics, match conditions, and team performance data for informed decision-making. As football becomes more data-driven, it enhances team performance and improves sport analytical understanding. Future iterations will incorporate more granular data and advanced ensemble methods.
Biologics Revolution: Mechanisms, Clinical Impact, and Emerging Trends
Authors: Garud Shrikant Subhash , Dhatrak Samadhan Ananda , Sayaji Thube Rushikesh , Chaudhari Amit Ambadas
Published: November 2024

Abstract: The rise of biologics has brought about a major change in modern medicine, offering new ways to treat complex and chronic diseases. Unlike traditional drugs, biologics are created from living cells, making them larger and more intricate. These therapies work by targeting specific parts of the immune system, which helps in treating conditions like cancer, autoimmune disorders, and infectious diseases more effectively. In recent years, biologics have shown great promise in clinical trials, providing better outcomes for patients who haven’t responded well to standard treatments. This review explores how biologics work, their impact on patient care, and emerging trends in this field, such as biosimilars and personalized medicine. Together, these advancements hold potential to improve treatment options and make biologics more accessible.