bluuebunny/crossref_metadata_2025 huggingface dataset:
Los modos de organizar la atención de salud pública de niñes con discapacidad.
Authors: Pereyra Cristina del Valle
Published: December 2021

El presente artículo deriva de una investigación socio-antropológica, acerca de las interrelaciones entre las maestras de apoyo a la inclusión (MAI) y les profesionales de salud (PS) en torno a niñes con discapacidad. La construcción de la información empírica se inicia en el año 2019 en un Centro de Servicios Alternativos y Complementarios (CSAYC), en escuelas primarias de educación común y en instituciones de salud pública vinculadas con la atención de niñes con discapacidad en la ciudad de Comodoro Rivadavia, provincia Chubut. Nos proponemos realizar una descripción acerca de los modos de organizar la atención de salud de niñes con discapacidad que habitan en contextos de desigualdad y pobreza urbana, a partir de los sentidos y prácticas que despliegan les profesionales de salud en distintas instituciones públicas. Planteamos que estas instituciones se encuentran atravesadas por situaciones de precariedad laboral y recortes presupuestarios debido a la crisis político- económico que vivencia la provincia de Chubut.
Analisis Batuan Gunungapi di Daerah Banyuwangi dan Sekitarnya, Provinsi Jawa Timur Berdasarkan Aspek Geokimia
Authors: Prabowo Arif , Permanadewi Sam , Samodra Hanang
Published: December 2021

Batuan gunungapi (lava) di daerah Banyuwangi dan sekitarnya merupakan litologi penyusun Formasi Batuampar dan Merubetiri yang berumur Oligo-Miosen, serta terdapat pada batuan gunungapi Kuarter. Sebaran batuan gunungapi tua mendominasi daerah pantai selatan, sedangkan yang lebih muda (Kuarter) terdapat di bagian utara daerah penelitian. Hasil analisis geokimia 8 (delapan) sampel batuan gunungapi umumnya berjenis basal yang berasal dari seri magma toleit, bersifat metaluminous dan berasal dari kedalaman antara 52,26-169,41 km. Data dan informasi ilmiah analisis geokimia dapat digunakan untuk penelitian, pendidikan dan kegiatan geowisata berdasarkan pemahaman geologi yang lengkap.Katakunci: Banyuwangi, batuan gunungapi, geokimia, lavaKata kunci : Banyuwangi, Batuan Gunungapi, Lava, GeokimiaÂ
DFT/TDDFT studies of the structural, electronic, NBO and non-linear optical proper-ties of triphenylamine functionalized tetrathiafulvalene
Authors: BOUACHRINE Mohammed , AZAID Ahmed , ABRAM Tayeb , KACİMİ Rchid , RAFTANI Marzouk , SBAİ Abdelouahid , LAKHLIFI Tahar
Published: December 2021

In this paper, we present a theoretical analysis of the molecular structure of a conjugated molecule TTPA-TTF at the DFT level using the B3LYP method and the 6-31G (d) basis set. The TTPA-TTF mole-cule presented a twisted configuration, which gave it good solubility in different organic solvents. The Partial atomic charge, molecular electrostatic potential (MEP) map, and global reactivity descriptors highlight the reactive sites of the molecule with the possible prediction of its reactivity. Moreover, a clear image of the intra- and intermolecular interactions illustrates hyperconjugative interactions based on the charge delocalization that emerges from the natural bond orbital analysis. The non-linear optical proper-ties of the TTPA-TTF molecule can also be calculated by determining their first hyperpolarizabilities. The time-dependent density theory method TD-DFT-B3LYP 6-31G (d) was used for the study of absorption. The obtained results show a broad spectrum in the visible range favorable to harvest solar light.
Acoustic analysis of swallowing as an auxiliary method for assessing dysphagia in Parkinson's disease
Authors: Silva Glauce Souza da , Figueiredo Ana Clara Gonçalves de , Zeigelboim Bianca Simone , Araújo Cristiano Miranda de , Stechmann Neto José , Santos Rosane Sampaio
Published: December 2021

Objective: To measure the accuracy of DeglutiSom as an auxiliary method to assess swallowing in patients with Parkinson's disease (PD). Methodology: Accuracy study. Among 248 individuals, 91 participants met the inclusion criteria, with a mean age of 64.9 years (SD 7.7), 53.8% male and 46.2% female, with a mean disease duration of 12.6 years (SD 3.8 years). Two instrumental studies were performed: An acoustic analysis with Sonar Doppler via the DeglutiSom Software, and a videofluoroscopic swallow study. Three judges analyzed the swallowing sounds in the DeglutiSom software and the instrumental examination findings. Results: The inter-rater reliability was 90.1%, with 4.4% degree of partial agreement and 5.5% disagreement. Sensitivity resulted in 90.0% and specificity in 90.0%. A sensitivity of 97.0% and specificity of 91.0% are indicators of a high validity for the dysphagia screening method, with predictive value (+) of 97.0% and predictive value (-) of 91.0%, with an accuracy method of 96.0%. The validity indicator values for screening aspiration were also high, with a sensitivity of 90.0%, specificity of 90.0%, predictive value (+) of 82.0%, predictive value (-) of 95% , 0% and 90.0% accuracy. Conclusion: The method proposed is considered appropriate for oropharyngeal dysphagia and tracheal aspiration screening in patients with Parkinson's Disease.
Potential utilization of glycerol as crosslinker in starch films for application in Regenerative Dentistry
Authors: Rodrigues Simone , Fornazier Mariana , Magalhães Denildo , Ruggiero Reinaldo
Published: December 2021

Periodontal disease results in damage to dental insertion apparatus. Regenerative procedures are proposed to replace lost structures in the context of guided tissue regeneration (GTR), guided bone regeneration (GBR) techniques and frequently associate bone substitutes with physical barriers aiming at greater longevity and improvement of aesthetic pattern. This study evaluates the possibility of using glycerol as a starch films modifying agent, acting as a cross-linking agent, without compromising its plasticizing effect. Biodegradable cassava starch films were prepared incorporating glycerol at concentrations of 0, 15, 20, 30 and 40% aiming application at dental regenerative procedures. The characterization of films by microscopy (SEM), thermal analysis (DSC), spectroscopic (UV / Vis., FTIR, XRD), mechanical (Traction), and analysis of protein swelling, degradation and diffusion and physiological temperature) showed that the incorporation of glycerol in up to 20% attributed to the films a plasticizer character and in higher concentrations, conferred a greater interaction of glycerol (crosslinking) with the starch chains and a degradation time that allows the physical barrier in RTG and ROG. The films presented mechanical resistance, malleability and permissiveness to protein diffusion in the in vitro assays, which meet the current attributes that guide the use of these resources in biomaterials.
Apitoxina como ferramenta auxiliar na profilaxia da infecção contra SARS-CoV-2
Authors: Cerqueira Rilkaelle Gomes de Melo , Ibiapina Sofia Isis de Oliveira , Moreira Mariana de Carvalho , Pereira Lara Vitória de Araújo Costa , Silva Luciane Costa , Sá Marcela Coelho de , Rocha Izaura Maria , Reis Liana Cynthia de Macedo , Sousa Marcos André Arrais de , Monteiro Amanda Laurindo , Castro Sérgio Augusto Dias , Rodrigues Augusto Cesar Evelin , Silva Francisco Laurindo da
Published: December 2021

O SARS-CoV-2 faz parte do grupo familiar do betacoronavírus, responsável pelos maiores índices de morbimortalidade na população. Em março de 2020 o mundo entrou em estado de emergência devido a pandemia pelo betacoronavírus que ocasiona a doença Covid-19, por isso há a busca de terapêuticas eficazes para o controle da pandemia. A apitoxina vem despertando interesse pela possibilidade da sua utilização na modulação do sistema imunológico na inativação de vírus. Nesse sentido, o projeto de pesquisa teve como objetivo principal analisar o uso da apitoxina como uma ferramenta auxiliar na profilaxia da infecção ocasionada pelo SARS-CoV-2. A apitoxina foi obtida de abelhas pertencentes à espécie Apis Mellifera, por meio de choque elétrico. Na execução dos ensaios foram utilizados ratos pertencentes a espécie Wistar, com aproximadamente 350g de peso e todos da mesma linhagem. Utilizou-se 15 animais nos experimentos. A dose de apitoxina inoculada nos animais foi 30 μg/mL A coleta do sangue nos animais foi realizada em triplicata randomicamente, nos intervalos de tempo de 7, 14, 21 e 28 dias. Os testes sorológicos foram realizados pelo método imunocromatográfico para o SARS-CoV-2. Os resultados demonstraram a produção de IgM anti- SARS-CoV-2, nos intervalos de tempo em que foram feitas as coletas do sangue dos animais. Portanto, a apitoxina na concentração utilizada, de fato induziu a produção de anticorpos pertencentes a classe IgM contra o SARS-CoV-2 em modelos animais e pode ser utilizada como uma ferramenta auxiliar na modulação do sistema imune, contra o vírus que ocasiona a Covid-19.
Análise da presença de microrganismos patógenos em maquiagens: revisão da literatura
Authors: Silva Jéssica Soares , Santos Morrana Porto , Santos Tayanne Andrade dos , Silva Tatielle Pereira
Published: December 2021

Este artigo tem como objetivo analisar estudos científicos que avaliaram a presença de microrganismos patogênicos em cosméticos. Desta forma, foi realizada uma revisão de literatura, a partir das bases de dados scielo, google acadêmico, Seminário Transdisciplinar da Saúde, Revista de ciências farmacêuticas básica e aplicada, entre outras fontes de dados, publicados nos idiomas português e inglês. Os cosméticos são preparações compostas por substâncias naturais ou sintéticas que podem ser utilizadas externamente em várias partes do corpo humano, e tem por finalidade limpar, adicionar fragrância, alterar sua aparência ou corrigir o odor corporal. Algumas maquiagens podem causar reações adversas aos usuários. Esses efeitos geralmente podem ser causados ​​por fatores pessoais como fisiológicos ou pelo uso impróprio do produto, portanto, testes biológicos para avaliação de segurança devem ser realizados antes que os cosméticos sejam colocados no mercado. A garantia na qualidade dos cosméticos é um fator de suma importância no que diz respeito à saúde da pele. Vários microrganismos, patógenos ou não, podem estar presentes nas formulações cosméticas, com tudo a presença de outros microrganismos oriundos do uso constante e até indevido destes cosméticos podem levar a um desequilíbrio da microflora da pele cosmética. Conclui-se, a partir dos resultados deste estudo, a presença de bactérias do grupo Staphylococcus em cosméticos, sendo elas subdivididas em: aureus e epidermidis. Tais bactérias podem trazer prejuízos para a saúde humana, que vão desde infecções simples até as mais complexas devido ao fato de que os cosméticos são produtos não estéreis.
Fatores desencadeantes de depressão na adolescência: uma revisão integrativa
Authors: Silva Jadiane de Jesus da , Siqueira Maria da Conceição Caetano de
Published: December 2021

Nos últimos anos os transtornos mentais vêm atingindo a população em grande escala, se tornando um dos assuntos mais comentados da atualidade, sendo estes caracterizados por um grupo de distúrbios psíquicos que desencadeiam sintomas envolvendo principalmente a emoção, a função cognitiva e a capacidade de controlar comportamentos complexos, que frequentemente cursam para o caminho crônico, dentre essas psicopatologias estão os transtornos depressivos que tem acometido a população de uma forma progressiva. O objetivo deste estudo é identificar os principais fatores desencadeantes de depressão entre adolescentes. Realizou-se uma revisão integrativa da literatura através de pesquisas em bases de dados utilizando estudos completos e disponíveis nas bases de dados científicas que tinham sido publicados no período de 2010 a 2020. Foram selecionados após a leitura exploratória um total de 15 trabalhos que se enquadram aos objetivos da pesquisa. Os principais fatores desencadeantes de depressão entre adolescentes evidenciados foram: conflitos familiares; vulnerabilidade social; gênero e idade; aspectos psicoafetivos e psicossociais. Com base nas pesquisas realizadas foi possível evidenciar que a depressão entre os adolescentes é multifatorial assim como nos adultos, várias situações corroboram para o seu surgimento, porém grande parte dos estudos apontou como principal fator o âmbito familiar, a forma como esses adolescentes são criados, educados e o vínculo que os mesmos têm com os pais.
Prevalência e impactos da pandemia COVID-19 em adolescentes residentes na região da calha norte do estado do Pará
Authors: Marques Bruna Carvalho , Costa Francimara Guimarães , Valente Antônia Regiane Pereira Duarte
Published: December 2021

A rápida disseminação da COVID-19 atraiu a atenção mundial desde seu surgimento. Portanto, algumas estratégias foram adotadas para conter o desenvolvimento da doença, como o distanciamento e o isolamento social, mas essas medidas causaram consequências físicas e psicossociais, sobretudo para os adolescentes, cujo cotidiano foi completamente alterado. Identificar o quantitativo de casos de COVID-19 nos adolescentes nos municípios que compõe a calha Norte do estado do Pará; descrever a prevalência a cada 100 adolescentes. Pesquisa bibliográfica documental, com abordagem quantitativa e qualitativa realizada através de coleta de dados no Ministério da Saúde e Secretaria de Saúde Pública do estado do Pará, bem como nas bases de dados: Scielo, Lilacs, PubMed, Google Acadêmico e Periodics CAPES. Coletou-se o número de casos notificados por municípios entre o período de 3 de abril de 2020 a 12 de setembro de 2021, entre a faixa etária de 12 à 19 anos, sexo e prevalência. Constatou-se que dentre os municípios analisados Oriximiná apresentou maior prevalência, entretanto Terra Santa e Prainha apresentaram menor prevalência. Foram analisados dez estudos voltados aos impactos causados na vida dos adolescentes, durante período pandêmico. O estudo cumpriu os objetivos estabelecidos. Discorrer sobre a prevalência e os impactos ocorridos nesse período foi de grande relevância em nível de conhecimento científico. Sugerem-se mais produções de estudos epidemiológicos abrangendo a saúde do adolescente e pesquisas de campo voltadas para esse público, que certamente contribuirá para criação de políticas públicas e para o enriquecimento do acervo cientifico.
Tinjauan Hukum Gugatan Pembatalan Hibah dari Ayah Kepada Anak
Authors: Faizah Nadjematul , Zahra Siti Fatimatu
Published: December 2021

This research is a literature study (library research/content analysis) with the type of normative legal research through a statute approach, an Islamic law approach and a case approach. The results of this study conclude that parents may donate assets to their children, grants are made by paying attention to justice between their children. Even though a parent can withdraw the grant, a valid reason and evidence must be had, because the grant cannot be withdrawn immediately, even though the grant is given from the father to his child. In the case discussed in this study, the Panel of Judges decided to reject the grant cancellation lawsuit filed by the father against his children. the absence of the ex-wife's consent to withdraw the grant from the joint property.
Analisis Kesesuaian UU No. 33 Tahun 2014 Tentang Jaminan Produk Halal Pada Pangan Impor di Indomaret Wilayah Kabupaten Kuningan
Authors: Aulia Mulfi , Hanifah Alya
Published: December 2021

This study uses a field research method with a qualitative approach. Qualitative data on the procurement process for imported products and product sales under the JPH Law were obtained through interviews with store heads, observations and documentation of Indomaret outlets in the Kuningan Regency area. The results of this study indicate, first, the provisions for imported food products that can be found in Indonesia according to the JPH Law, namely the discovery of the appropriate halal label on the product and has a halal certificate and has a registration number (this is specifically for halal certified products abroad, it is mandatory to register to) BPJPH and its registration number on the product). Second, the products supplied to Indomaret in the Kuningan Regency area come from one Distribution Center (DC), namely DC Cirebon, so it can be ascertained that all products sold at Indomaret outlets in the area, including imported food products, are the same. Third, during the five-year transition period (October 2014-October 2019) it turned out that some importers had not utilized optimally to implement halal certification of products. The proof is that in 2021, which means that two years have passed since the transition period, there are still products that are not labeled as halal or labeled as not halal in Indomaret, the Kuningan Regency area.
Intellectual Capital and Disclosure Practices of Miscellaneous Industries: Evidence from Cable Companies in Indonesia
Authors: Partiwi Dwi Astuti  , Anis Chariri  , Abdul Rohman
Published: December 2021

The important role of intellectual capital for value creation has led many companies to disclose their intellectual capital information in annual reports. This study aims to provide, via content analysis, an overview of the disclosure and presentation of intellectual capital information in the annual reports of cable companies listed on the Indonesia Stock Exchange in 2015. This study found that structural capital is the most common category of intellectual capital disclosed in the annual reports. In addition, most intellectual capital disclosures are discursive, with positive and past-oriented information. However, there is no systematic framework for disclosing intellectual capital information in annual reports. Disclosures made do not have a special pattern and are still random. This finding may contribute to an understanding of how companies communicate intellectual capital information for their own benefit, as well as the benefit of stakeholders, customers and employees.
The Condition and Challenges of Community Learning Centre in the Oil Palm Plantations of Sarawak, Malaysia
Authors: Bemen Win-Keong Wong  , Suriati Ghazali  , Nooriah Yusof
Published: December 2021

Sarawak is facing the problem of labour shortage in its oil palm plantations. It is difficult to recruit Malaysians to work in the plantations and, therefore, hiring foreign workers has become one of the solutions. Since the number of Indonesian workers and children is increasing, the Indonesian Government has requested to set up Community Learning Centre (CLC) in plantations for the Indonesian children in Sarawak. This article aims to explore the existence of CLC and the challenges faced by its teachers. A qualitative study has been employed, and data was collected using face-to-face interviews and interviews via telephone and text messages. The face-to-face interviews were conducted before and after the Movement Control Order was implemented in Sarawak. The first 16 CLCs were set up in 2016, and the number increased to 63 in 2020. CLC uses the Indonesian teaching syllabus, and the subjects are taught by Indonesian teachers (Guru Pamong and Guru Bina). Up to June 2020, there were 114 Indonesian CLC teachers in the state. The constraints of the CLC in Sarawak include limited classrooms, low motivation of the students, and lack of teaching and learning equipment which affects the effectiveness of teaching and learning. On the bright side, the CLC has given an opportunity to the Indonesian children in oil palm plantations in Sarawak to have primary education. After graduating from CLC, they can continue their studies in a secondary school in Indonesia since the teaching syllabus in CLC is similar to the one used in Indonesia.
Application of Shariah Enterprise Theory on Disclosure of Corporate Social Responsibility in Sharia Banking
Authors: Eti Kusmiati  , Ungkari Marti Dewi
Published: December 2021

The goal of this research is to find out what information Islamic banks provide in their corporate social responsibility reports, as well as to determine the acceptability of such material in terms of Shariah Enterprise Theory (SET). This study employed a qualitative research method using a case study methodology. Primary and secondary data are the two types of data used. Data reduction, data presentation, and verification are some of the data processing strategies employed. Findings. The findings of the research demonstrate that Bank Muamalat's CSR disclosures contained Sharia Enterprise Theory disclosure elements such as vertical and horizontal accountability, indicating that Bank Muamalat Indonesia has declared its social responsibility in a very informative manner.
Photosynthetic Conversion of CO2 Into Pinene Using Engineered Synechococcus sp. PCC 7002
Authors: Yang Ruigang , Zhu Lingyun , Li Tao , Zhu Lv-yun , Ye Zi , Zhang Dongyi
Published: December 2021

Metabolic engineering of cyanobacteria has received much attention as a sustainable strategy to convert CO2to various longer carbon chain fuels. Pinene has become increasingly attractive since pinene dimers contain high volumetric energy and have been proposed to act as potential aircraft fuels. However, cyanobacteria cannot directly convert geranyl pyrophosphate into pinene due to the lack of endogenous pinene synthase. Herein, we integrated the gene encodingAbies grandispinene synthase into the model cyanobacteriumSynechococcussp. PCC 7002 through homologous recombination. The genetically modified cyanobacteria achieved a pinene titer of 1.525 ± 0.l45 mg L−1in the lab-scale tube photobioreactor with CO2aeration. Specifically, the results showed a mixture ofα- andβ-pinene (∼33:67 ratio). The ratio ofβ-pinene in the product was significantly increased compared with that previously reported in the engineeredEscherichia coli. Furthermore, we investigated the photoautotrophic growth performances ofSynechococcusoverlaid with different concentrations of dodecane. The work demonstrates that the engineeredSynechococcusis a suitable potential platform forβ-pinene production.
Regeneration in Echinoderms: Molecular Advancements
Authors: Medina-Feliciano Joshua G. , García-Arrarás José E.
Published: December 2021

Which genes and gene signaling pathways mediate regenerative processes? In recent years, multiple studies, using a variety of animal models, have aimed to answer this question. Some answers have been obtained from transcriptomic and genomic studies where possible gene and gene pathway candidates thought to be involved in tissue and organ regeneration have been identified. Several of these studies have been done in echinoderms, an animal group that forms part of the deuterostomes along with vertebrates. Echinoderms, with their outstanding regenerative abilities, can provide important insights into the molecular basis of regeneration. Here we review the available data to determine the genes and signaling pathways that have been proposed to be involved in regenerative processes. Our analyses provide a curated list of genes and gene signaling pathways and match them with the different cellular processes of the regenerative response. In this way, the molecular basis of echinoderm regenerative potential is revealed, and is available for comparisons with other animal taxa.
Neuraminidase1 Inhibitor Protects Against Doxorubicin-Induced Cardiotoxicity via Suppressing Drp1-Dependent Mitophagy
Authors: Qin Yating , Lv Chao , Zhang Xinxin , Ruan Weibin , Xu Xiangyu , Chen Chen , Ji Xinyun , Lu Li , Guo Xiaomei
Published: December 2021

Anthracyclines, such as doxorubicin (DOX), are among the effective chemotherapeutic drugs for various malignancies. However, their clinical use is limited by irreversible cardiotoxicity. This study sought to determine the role of neuraminidase 1 (NEU1) in DOX-induced cardiomyopathy and the potential cardio-protective effects of NEU1 inhibitor oseltamivir (OSE). Male Sprague–Dawley (SD) rats were randomized into three groups: control, DOX, and DOX + OSE. NEU1 was highly expressed in DOX-treated rat heart tissues compared with the control group, which was suppressed by OSE administration. Rats in the DOX + OSE group showed preserved cardiac function and were protected from DOX-induced cardiomyopathy. The beneficial effects of OSE were associated with the suppression of dynamin-related protein 1 (Drp1)-dependent mitochondrial fission and mitophagy. In detail, the elevated NEU1 in cardiomyocytes triggered by DOX increased the expression of Drp1, which subsequently enhanced mitochondrial fission and PINK1/Parkin pathway-mediated mitophagy, leading to a maladaptive feedback circle towards myocardial apoptosis and cell death. OSE administration selectively inhibited the increased NEU1 in myocardial cells insulted by DOX, followed by reduction of Drp1 expression, inhibition of PINK1 stabilization on mitochondria, and Parkin translocation to mitochondria, thus alleviating excessive mitochondrial fission and mitophagy, alleviating subsequent development of cellular apoptotic process. This work identified NEU1 as a crucial inducer of DOX-induced cardiomyopathy by promoting Drp1-dependent mitochondrial fission and mitophagy, and NEU1 inhibitor showed new indications of cardio-protection against DOX cardiotoxicity.
Dynamics of Water and Other Molecular Liquids Confined Within Voids and on Surface of Lignin Aggregates in Aging Bio Crude Oils
Authors: Bonini Massimo , Fratini Emiliano , Faraone Antonio
Published: December 2021

Neutron scattering methods were employed to study the microscopic structure and dynamics of Bio Crude Oils (BCOs) and their lignin fractions. The structure of the carbonaceous aggregates was investigated using Small Angle Neutron Scattering to reveal a fractal hierarchy as well as a growth of the aggregates as the aging of the BCO proceeds. Elastic Neutron Scattering measurements indicate that BCO liquid phase, comprised of water and other hydrogenated molecular liquids, is in a state of extreme confinement. Quasi-Elastic Neutron Scattering yields information on the molecular motions, indicating that long range translational diffusion is suppressed and only localized dynamics take place on the tens of picosecond time range. The obtained results provide quantitative information on the molecular activity, as aging proceed, in these reactive materials of relevance as potential renewable energy sources.
Application of One-Dimensional Nanomaterials in Catalysis at the Single-Molecule and Single-Particle Scale
Authors: Yuan Saisai , Zhang Qitao
Published: December 2021

The morphology of nanomaterials has a great influence on the catalytic performance. One-dimensional (1D) nanomaterials have been widely used in the field of catalysis due to their unique linear morphology with large specific surface area, high electron-hole separation efficiency, strong light absorption capacity, plentiful exposed active sites, and so on. In this review, we summarized the recent progress of 1D nanomaterials by focusing on the applications in photocatalysis and electrocatalysis. We highlighted the advanced characterization techniques, such as scanning tunneling microscopy (STM), atomic force microscopy (AFM), surface photovoltage microscopy (SPVM), single-molecule fluorescence microscopy (SMFM), and a variety of combined characterization methods, which have been used to identify the catalytic action of active sites and reveal the mechanism of 1D nanomaterials. Finally, the challenges and future directions of the research on the catalytic mechanism of single-particle 1D nanomaterials are prospected. To our best knowledge, there is no review on the application of single-molecule or single-particle characterization technology to 1D nanomaterial catalysis at present. This review provides a systematic introduction to the frontier field and opens the way for the 1D nanomaterial catalysis.
Multidisciplinary Team Managements and Clinical Outcomes in Patients With Pulmonary Arterial Hypertension During the Perinatal Period
Authors: Shu Tingting , Feng Panpan , Liu Xiaozhu , Wen Li , Chen Huaqiao , Chen Yunwei , Huang Wei
Published: December 2021

Background: Pulmonary arterial hypertension (PAH) patients with pregnancy have high maternal mortality. This study aimed to provide clinical evidence with multidisciplinary team (MDT) management and to evaluate the clinical outcomes in PAH patients during the perinatal period.

Methods: We conducted a retrospective evaluation of PAH patients pregnant at the First Affiliated Hospital of Chongqing Medical University between May 2015 and May 2021.

Results: Twenty-two patients (24 pregnancies) were included in this study and received MDT management, and 21 pregnancies chose to continue pregnancy with cesarean section. Nine (37.5%) were first-time pregnancies at 27.78 ± 6.16 years old, and 15 (62.5%) were multiple pregnancies at 30.73 ± 3.71 years old. The average gestational week at hospitalization and delivery were 29.38 ± 8.63 weeks and 32.37 ± 7.20 weeks, individually. Twenty-one (87.5%) pregnancies received single or combined pulmonary vasodilators. The maternal survival rate of PAH patients reached 91.7%. Fifteen (62.5%) pregnancies were complicated with severe adverse events. Patients with complicated adverse events showed lower percutaneous oxygen saturation (SpO2), lower albumin, lower fibrinogen, higher pulmonary artery systolic pressure (PASP), higher blood pressure, longer activated partial thromboplastin time, and longer coagulation time. Fourteen (66.7%) pregnancies with cesarean sections were prematurely delivered and 85.7% newborns who survived after the operation remained alive.

Conclusion: The survival rate of parturients with PAH was improved in relation to MDT and pulmonary vasodilator therapy during the perinatal period compared with previous studies. SpO2, albumin, PASP, blood pressure, and coagulation function should be monitored carefully in PAH patients during pregnancy.
Elevation of the Gangdese Mountains and Their Impacts on Asian Climate During the Late Cretaceous—a Modeling Study
Authors: Zhang Jian , Liu Yonggang , Fang Xiaomin , Zhang Tao , Zhu Chenguang , Wang Chengshan
Published: December 2021

Uplift of the Gangdese Mountains is important to the evolution of Asian monsoons and the formation of Tibetan Plateau, but its paleoaltitude before the India-Asia collision (Late Cretaceous) is less constrained so far. In this study, we investigate whether the geological records, which are indicators of soil dryness, discovered in East Asia can provide such a constraint. Through climate modeling using the Community Earth System Model version 1.2.2, it is found that the extent of dry land in East Asia is sensitive to the altitude of the Gangdese Mountains. It expands eastwards and southwards with the rise of the mountain range. Comparison of the model results with all the available geological records in this region suggests that the Gangdese Mountains had attained a height of ∼2 km in the Late Cretaceous.
Trends and Climate Response in the Phenology of Crops in Northeast China
Authors: Xiao Dengpan , Zhang Yi , Bai Huizi , Tang Jianzhao
Published: December 2021

Crop phenology is the process of crop growth and yield formation, which is largely driven by climatic conditions. It is vital to investigate the shifts in crop phenological processes in response to climate variability. Previous studies often only explored the response of a single crop phenology to climate change, and lacked comparative studies on the climate response in different crop phenology. We intend to investigate the trends in phenological change of three typical crops (i.e., maize, rice and soybean) in Northeast China (NEC) and their response to climate change during 1981–2010. Its main purpose is to reveal the differences in the sensitivity of different crop phenology to key climate factors [e.g., mean temperature (T), accumulated precipitation (AP) and accumulated sunshine hours (AS) during the crop growth period]. We found that the three crops have different phenological changes and varying ranges, and significant spatial heterogeneity in phenological changes. The results indicated that the lengths of different crop growth stages [e.g., the vegetative growth period (VGP), the reproductive growth period (RGP) and the whole growth period (WGP)] were negatively correlated with T, especially in VGP and WGP. However, the lengths of growth period of the three crops were positively correlated with AP and AS. For each 1°C increase in T, the number of days shortened in WGP (about 5 days) was the largest, and that in RGP (less than 2 days) was the smallest. Therefore, the increases in T during past 3 decades have significantly shortened VGP and WGP of three crops, but had slight and inconsistent effects on RGP. Moreover, changes in AP has slight impact on the growth periods of maize and rice, and significantly shortened RGP and WGP of soybean. Changes in AS exerted important and inconsistent effects on the phenology of three crops. This study indicated that there are significant differences in the sensitivity and response of different crop phenology to climate factors. Therefore, in evaluating the response and adaptation of crops to climate change, comparison and comprehensive analysis of multiple crops are helpful to deeply understand the impact of climate change on crop production.
Study on Load-Participated Demand Response Model Based on Load Aggregator
Authors: Pei Zixia , Ma Yunlong , Wu Mengyun , Yang Jianlan
Published: December 2021

In the reform of the electricity market, along with the gradual opening of the electricity sales side as well as the increase in the proportion of residential electricity consumption, the user load of the demand side has become an essential resource for demand response (DR). To efficiently utilize the residential load resources, new market participants, such as load aggregator (LA) have emerged. First, the basic concept of load aggregator is introduced in this paper, the origin and definition of LA is studied, and the classification of aggregated resources and the current situation of LA operation in some countries are presented. Then the article analyzes the market operation mode of LA and the uncertainty of LA in operation in detail, including the LA service on the user side, transaction mode and hierarchical structure associated with the operation, the uncertainty classification analysis, and associated strategies to address the problem. The LA load integration method and the scheduling control strategy are discussed. Finally, suggestions and ideas on the future research direction are proposed.
Identification of a Risk Locus at 7p22.3 for Schizophrenia and Bipolar Disorder in East Asian Populations
Authors: Li Wenqiang , Zhang Chu-Yi , Liu Jiewei , Guan Fanglin , Shao Minglong , Zhang Luwen , Liu Qing , Yang Yongfeng , Su Xi , Zhang Yan , Xiao Xiao , Luo Xiong-Jian , Li Ming , Lv Luxian
Published: December 2021

Background: Shared psychopathological features and mechanisms have been observed between schizophrenia (SZ) and bipolar disorder (BD), but their common risk genes and full genetic architectures remain to be fully characterized. The genome-wide association study (GWAS) datasets offer the opportunity to explore this scientific question using combined genetic data from enormous samples, ultimately allowing a better understanding of the onset and development of these illnesses.

Methods: We have herein performed a genome-wide meta-analysis in two GWAS datasets of SZ and BD respectively (24,600 cases and 40,012 controls in total, discovery sample), followed by replication analyses in an independent sample of 4,918 SZ cases and 5,506 controls of Han Chinese origin (replication sample). The risk SNPs were then explored for their correlations with mRNA expression of nearby genes in multiple expression quantitative trait loci (eQTL) datasets.

Results: The single nucleotide polymorphisms (SNPs) rs1637749 and rs3800908 at 7p22.3 region were significant in both discovery and replication samples, and exhibited genome-wide significant associations when combining all East Asian SZ and BD samples (29,518 cases and 45,518 controls). The risk SNPs were also significant in GWAS of SZ and BD among Europeans. Both risk SNPs significantly predicted lower expression of MRM2 in the whole blood and brain samples in multiple datasets, which was consistent with its reduced mRNA level in the brains of SZ patients compared with normal controls. The risk SNPs were also associated with MAD1L1 expression in the whole blood sample.

Discussion: We have identified a novel genome-wide risk locus associated with SZ and BD in East Asians, adding further support for the putative common genetic risk of the two illnesses. Our study also highlights the necessity and importance of mining public datasets to explore risk genes for complex psychiatric diseases.
Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells
Authors: Harcha Paloma A. , López-López Tamara , Palacios Adrián G. , Sáez Pablo J.
Published: December 2021

The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated autocrine and paracrine signaling. We also summarize the contribution of PANXs with the cytoskeleton, which is also key regulator of cell migration. PANXs, as mechanosensitive ATP releasing channels, provide a unique link between cell migration and purinergic communication. The functional association with several purinergic receptors, together with a plethora of signals that modulate their opening, allows PANX channels to integrate physical and chemical cues during inflammation. Ubiquitously expressed in almost all immune cells, PANX1 opening has been reported in different immunological contexts. Immune activation is the epitome coordination between cell communication and migration, as leukocytes (i.e., T cells, dendritic cells) exchange information while migrating towards the injury site. In the current review, we summarized the contribution of PANX channels during immune cell migration and recruitment; although we also compile the available evidence for non-immune cells (including fibroblasts, keratinocytes, astrocytes, and cancer cells). Finally, we discuss the current evidence of PANX1 and PANX3 channels as a both positive and/or negative regulator in different inflammatory conditions, proposing a general mechanism of these channels contribution during cell migration.
Regulatory Role of Fc Receptor in mIgM+ B Lymphocyte Phagocytosis in Flounder (Paralichthys olivaceus)
Authors: Hao Yanbo , Tang Xiaoqian , Xing Jing , Sheng Xiuzhen , Chi Heng , Zhan Wenbin
Published: December 2021

Fc receptor (FcR) is an important opsonin receptor on the surface of immune cells, playing an important role in antibody-dependent cell-mediated immunity. Our previous work found that the FcR of flounder showed a marked expression response in phagocytizing IgM+ B cell, which suggested that FcR might participate in regulating Ig-opsonized phagocytosis. In this paper, in order to elucidate the potential role of FcR in mediating phagocytosis of IgM+ B cell, flounder anti-E. tarda serum was prepared and complement-inactivated for the use of E. tarda opsonization, and the sera of healthy flounder were used as control. Flow cytometric analysis showed that the phagocytosis rates of antiserum-opsonized E. tarda in peripheral blood mIgM+ B lymphocytes were significantly higher than the control group, and higher phagocytosis rates of mIgM+ B lymphocyte could be detected with an increasing incubation time ranging from 1 to 5 h. The phagocytosis rates of antiserum-opsonized E. tarda by mIgM+ B lymphocyte for an incubation time of 1, 3 or 5 h were 51.1, 63.0, and 77.5% respectively, which were significantly higher than the phagocytosis rates in the control groups with 40.2, 50.9, and 63.8%, respectively. While the Fc fragment of IgM on the surface of opsonized E. tarda was blocked by rabbit anti-flounder IgM polyclonal antibodies, phagocytosis rates of mIgM+ B lymphocyte decreased significantly compared with the unblocked group. Moreover, the proportion of mIgM+ B lymphocytes with higher intracellular reactive oxygen species (ROS) levels rose to 32.1% from the control level of 23.0% after phagocytosis of antiserum-opsonized E. tarda. FcγRII and Syk were found to be significantly upregulated, while FcγRIII was significantly downregulated in the mIgM+ B lymphocytes post phagocytosis. Furthermore, when FcγRII of mIgM+ B lymphocytes was blocked by the prepared antibodies, their phagocytosis rate of antiserum-opsonized E. tarda was 39.0%, which was significantly lower than the unblocked group of 54.0%. These results demonstrate that FcR plays a critical role in mediating phagocytosis and bactericidal activity of mIgM+ B lymphocytes, which would facilitate an improved understanding of the regulatory roles of FcR in phagocytosis of teleost B lymphocytes.
Degradation Behaviors of Two Epoxy Coatings After Dry/Wet-Accelerated Fog Exposure of Different Solutions
Authors: Zhang Jibiao , Zhu Bo , Wang Haoran , Zhang Cheng , Zeng Weixiu , Zhou Qixin
Published: December 2021

Applying organic coating is an important and effective approach for the protection of metal from corrosion. Weathering degradation and under-film corrosion are the two major important factors that cause the failure of organic coatings. In this work, the degradation investigation of two epoxy coatings (clear and pigmented coatings) was carried out under the dry–wet circulation of three different water fog solutions (deionized water, 0.5 wt% NaCl, 0.05 wt% NaCl + 0.35 wt% (NH4)2SO4) in 35 days. The apparent performance (pull-off adhesion and surface potentials) and electrochemical features [electrochemical noise and electrochemical impedance spectroscopy (EIS)] of the coating samples were monitored after dry–wet fog exposure. In our three accelerating systems of the fog atmosphere, the time that the detectable defects appeared on the surface of coating samples was far ahead in the mixed salt solution than that in the deionized water or 0.5 wt% NaCl solution. For a defective or damaged coating surface, the derived results by using the standard deviation method (SDM) or Fourier power spectrum (FPS) were rather higher than those obtained from EIS as a whole, while for the same coating, the degradation trend with time derived from EIS, SDM, FPS, and scanning Kelvin probe was consistent with each other.
Effect of Intermittent Ultrasonic Vibration-Assisted Compression on the Mechanical Properties of Zr-Based Amorphous Alloys
Authors: Lingyun Yang , Shenpeng Xu , Yan Lou
Published: December 2021

Bulk amorphous alloys have some good mechanical properties due to their special atomic arrangement and are now popular in the field of materials. Zr-based amorphous alloys have good mechanical properties, but they are different from lattice slip materials with high ductility. When these materials are compressed and deformed, it generates a concentrated elastic force in the shear zone that causes instantaneous amorphous fracture. The extremely poor plasticity of Zr-based amorphous materials highlight their shortcomings and make them difficult to use in engineering applications. In this paper, it is found that the plasticity of Zr-based amorphous alloys is enhanced to a certain extent by intermittent ultrasonic vibration-assisted compression (IUVC). The ultrasonic vibration stress of IUVC can increase the extra free volume of Zr-based amorphous alloys and increase their degree of “rejuvenation”, which is manifested as an increase in plasticity. To explore how IUVC affects the plasticity of Zr-based amorphous alloys, we design experiments to analyse the effects of different intermittent times, pre-pressures and ultrasonic amplitudes on the plasticity of amorphous alloys.
Community Outbreak Moderates the Association Between COVID-19-Related Behaviors and COVID-19 Fear Among Older People: A One-Year Longitudinal Study in Taiwan
Authors: Kuo Yi-Jie , Chen Yu-Pin , Wang Hsiao-Wen , Liu Chieh-hsiu , Strong Carol , Saffari Mohsen , Ko Nai-Ying , Lin Chung-Ying , Griffiths Mark D.
Published: December 2021

Although health behavior theories indicate that fear is effective in activating preventive behaviors, the question of whether COVID-19 severity moderates the association between fear of COVID-19 and preventive behaviors remains unclear. The present study investigated the association between the fear of COVID-19 and preventive behaviors during the COVID-19 community outbreak of two severity levels in Taiwan. Data were obtained regarding the fear of COVID-19 and practice of preventive behaviors from 139 older people (mean age = 71.73 years; 30.2% men) through in-person interviews during a mild COVID-19 outbreak period (baseline assessment). Data from 126 of the 139 participants were obtained again through a telephone interview during a severe COVID-19 outbreak period (follow-up assessment). A significant increase in the fear of COVID-19 (d = 0.39, p < 0.001) and a decrease in preventive behaviors (d = 0.63, p < 0.001) were found in the follow-up assessment. The association between fear of COVID-19 and preventive behaviors was not significant at baseline (r = −0.07, p > 0.05) but became significant at the follow-up assessment (r = 0.32, p < 0.001). The severity of a COVID-19 outbreak may alter older people's psychological status and related behaviors.
Impact of Plasma 5 Hydroxyindoleacetic Acid, a Serotonin Metabolite, on Clinical Severity in Acute Respiratory Distress Syndrome
Authors: Tanaka Takeshi , Mori Masahiko , Tashiro Masato , Izumikawa Koichi
Published: December 2021

Acute respiratory distress syndrome (ARDS) is characterized by dysregulated vascular permeability. The clinical outcomes remain poor, and the disease burden is widespread. We demonstrated that plasma 5-hydroxyindoleacetic acid (5-HIAA), a serotonin metabolite, is a pivotal severity indicator of ARDS. Serotonin is an effector of cellular contraction and a modulator of vascular permeability. Plasma 5-HIAA levels were significantly elevated in severe ARDS cases with shock status (p = 0.047) and positively correlated with SOFA (p < 0.0001) and APACHE-II score (p < 0.0001). In the longitudinal analysis, plasma 5-HIAA levels were also a strong independent predictor of mortality rate (p = 0.005). This study indicates that plasma 5-HIAA is a biomarker of ARDS severity and highlights the importance of evaluating vascular leakage levels for ARDS treatment.
Revisiting I-BAR Proteins at Central Synapses
Authors: Chatzi Christina , Westbrook Gary L.
Published: December 2021

Dendritic spines, the distinctive postsynaptic feature of central nervous system (CNS) excitatory synapses, have been studied extensively as electrical and chemical compartments, as well as scaffolds for receptor cycling and positioning of signaling molecules. The dynamics of the shape, number, and molecular composition of spines, and how they are regulated by neural activity, are critically important in synaptic efficacy, synaptic plasticity, and ultimately learning and memory. Dendritic spines originate as outward protrusions of the cell membrane, but this aspect of spine formation and stabilization has not been a major focus of investigation compared to studies of membrane protrusions in non-neuronal cells. We review here one family of proteins involved in membrane curvature at synapses, the BAR (Bin-Amphiphysin-Rvs) domain proteins. The subfamily of inverse BAR (I-BAR) proteins sense and introduce outward membrane curvature, and serve as bridges between the cell membrane and the cytoskeleton. We focus on three I-BAR domain proteins that are expressed in the central nervous system: Mtss2, MIM, and IRSp53 that promote negative, concave curvature based on their ability to self-associate. Recent studies suggest that each has distinct functions in synapse formation and synaptic plasticity. The action of I-BARs is also shaped by crosstalk with other signaling components, forming signaling platforms that can function in a circuit-dependent manner. We discuss another potentially important feature—the ability of some BAR domain proteins to impact the function of other family members by heterooligomerization. Understanding the spatiotemporal resolution of synaptic I-BAR protein expression and their interactions should provide insights into the interplay between activity-dependent neural plasticity and network rewiring in the CNS.