bluuebunny/crossref_metadata_2025 huggingface dataset:
Japanese Philosophy? No Such Thing: Japan's Contribution to World Philosophizing
Authors: Kasulis Thomas P.
Published: July 2019

For almost five decades I have been studying Japanese philosophy, but only gradually have I come to realize there is no such thing. The ghost of Nakae Chōmin 中江 兆民 (1847–1901) probably gloats with satisfaction to hear this gaijin say that. My statement seems to echo his assessment more than a century ago when he pronounced that Japan had always been and continued to be devoid of philosophy. Although I admire Chōmin for his intellectual courage, standing up to the thought police even to the extent of being temporarily exiled from Tōkyō, my position is not at all the same as his. Nakae Chōmin is not only dead, but unfortunately, when it came to understanding both philosophy and its relation to Japan, he was also dead wrong. So although in reference to Japanese philosophy, I claim there is no such thing, I do not mean what Chōmin meant. To understand what I do mean, we have to examine my claim word by word.
Assessing the Ability of Structure From Motion to Map High‐Resolution Snow Surface Elevations in Complex Terrain: A Case Study From Senator Beck Basin, CO
Authors: Meyer Joachim , Skiles S. McKenzie
Published: July 2019

The utility of differentially mapping snow depth to assess snow water resources at the watershed scale has been demonstrated using snow‐free and snow‐on lidar surface elevations. On more limited spatial and temporal scales, the same principle has been successfully applied with the relatively new photogrammetric technique Structure from Motion (SfM). Given the low cost of cameras relative to lidar technology, early studies are promising, yet it is well known that reconstructing elevations over bright snow surfaces in complex terrain has been a limitation for traditional photogrammetric methods. Therefore, before progressing to snow depth, it is worthwhile to constrain how well snow surface elevations are mapped with SfM. The lidar‐based Airborne Snow Observatory, which also has an RGB camera, provides a unique opportunity to assess SfM against coincidentally collected lidar. Here we present a lidar‐SfM snow surface elevation comparison from the 21 February 2017 flight, which took place in Senator Beck Basin, San Juan Mountains, CO, during the National Aeronautics and Space Administration (NASA) SnowEx campaign (Year 1). After coregistration of the two surface models, the normalized median absolute deviation was 0.17 m with a mean relative elevation difference of 0.014 m at identical spatial resolution of 1 m. The digital surface model was created without the use of ground control points, shows a promising potential to apply SfM for watershed‐scale surface elevation and snow depth mapping, and warrants further investigation of SfM as a supplement or alternative to lidar.
Imaging Spontaneous Imbibition in Full Darcy‐Scale Samples at Pore‐Scale Resolution by Fast X‐ray Tomography
Authors: Bartels W.‐B. , Rücker M. , Boone M. , Bultreys T. , Mahani H. , Berg S. , Hassanizadeh S. M. , Cnudde V.
Published: July 2019

Spontaneous imbibition is a process occurring in a porous medium which describes wetting phase replacing nonwetting phase spontaneously due to capillary forces. This process is conventionally investigated by standardized, well‐established spontaneous imbibition tests. In these tests, for instance, a rock sample is surrounded by wetting fluid. The following cumulative production of nonwetting phase versus time is used as a qualitative measure for wettability. However, these test results are difficult to interpret, because many rocks do not show a homogeneous but a mixed wettability in which the wetting preference of a rock varies from location to location. Moreover, during the test the flow regime typically changes from countercurrent to cocurrent flow and no phase pressure or pressure drop can be recorded. To help interpretation, we complement Darcy‐scale production curves with X‐ray imaging to describe the differences in imbibition processes between water‐wet and mixed‐wet systems. We found that the formation of a spontaneous imbibition front occurs only for water‐wet systems; mixed‐wet systems show localized imbibition events only. The asymmetry of the front depends on the occurrence of preferred production sites, which influences interpretation. Fluid layers on the outside of mixed‐wet samples increase connectivity of the drained phase and the effect of buoyancy on spontaneous imbibition. The wider implication of our study is the demonstration of the capability of benchtop laboratory equipment to image a full Darcy‐scale experiment while at the same time obtaining pore‐scale information, resolving the natural length and time scale of the underlying processes.
Comparison Between Fluid Simulation With Test Particles and Hybrid Simulation for the Kelvin‐Helmholtz Instability
Authors: Ma Xuanye , Delamere Peter A. , Nykyri Katariina , Burkholder Brandon , Neupane Bishwa , Rice Rachel C.
Published: July 2019

A quantitative investigation of plasma transport rate via the Kelvin‐Helmholtz (KH) instability can improve our understanding of solar‐wind‐magnetosphere coupling processes. Simulation studies provide a broad range of transport rates by using different measurements based on different initial conditions and under different plasma descriptions, which makes cross literature comparison difficult. In this study, the KH instability under similar initial and boundary conditions (i.e., applicable to the Earth's magnetopause environment) is simulated by Hall magnetohydrodynamics with test particles and hybrid simulations. Both simulations give similar particle mixing rates. However, plasma is mainly transported through a few big magnetic islands caused by KH‐driven reconnection in the fluid simulation, while magnetic islands in the hybrid simulation are small and patchy. Anisotropic temperature can be generated in the nonlinear stage of the KH instability, in which specific entropy and magnetic moment are not conserved. This can have an important consequence on the development of secondary processes within the KH instability as temperature asymmetry can provide free energy for wave growth. Thus, the double‐adiabatic theory is not applicable and a more sophisticated equation of state is desired to resolve mesoscale process (e.g., KH instability) for a better understanding of the multi‐scale coupling process.
LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases
Authors: Abe Taiki , Umeki Ikumi , Kanno Shin-ichiro , Inoue Shin-ichi , Niihori Tetsuya , Aoki Yoko
Published: July 2019

Leucine zipper-like transcriptional regulator 1 (LZTR1) encodes a member of the BTB-Kelch superfamily, which interacts with the Cullin3 (CUL3)-based E3 ubiquitin ligase complex. Mutations inLZTR1have been identified in glioblastoma, schwannomatosis, and Noonan syndrome. However, the functional role of LZTR1 in carcinogenesis or human development is not fully understood. Here, we demonstrate that LZTR1 facilitates the polyubiquitination and degradation of RAS via the ubiquitin-proteasome pathway, leading to the inhibition of the RAS/MAPK signaling. The polyubiquitination and degradation of RAS was also observed in cells expressing MRAS, HRAS, NRAS, and KRAS as well as oncogenic RAS mutants and inhibited the activation of ERK1/2 and cell growth. In vivo ubiquitination assays showed that MRAS-K127 and HRAS-K170 were ubiquitinated by LZTR1 and that the polyubiquitinated-chains contained mainly Ub-K48, K63, and K33-linked chains, suggesting its possible involvement in autophagy. Immunoprecipitation analyses showed the interaction of LZTR1 and RAS-GTPases with autophagy-related proteins, including LC3B and SQSTM1/p62. Co-expression of LZTR1 and RAS increased the expression of lipidated form of LC3B. However, long-term treatment with chloroquine had little effect on RAS protein levels, suggesting that the contribution of autophagy to LZTR1-mediated RAS degradation is minimal. Taken together, these results show that LZTR1 functions as a “RAS killer protein” mainly via the ubiquitin-proteasome pathway regardless of the type of RAS GTPase, controlling downstream signal transduction. Our results also suggest a possible association of LZTR1 and RAS-GTPases with the autophagy. These findings provide clues for the elucidation of the mechanisms of RAS degradation and regulation of the RAS/MAPK signaling cascade.
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs
Authors: Hollingsworth Scott A. , Kelly Brendan , Valant Celine , Michaelis Jordan Arthur , Mastromihalis Olivia , Thompson Geoff , Venkatakrishnan A. J. , Hertig Samuel , Scammells Peter J. , Sexton Patrick M. , Felder Christian C. , Christopoulos Arthur , Dror Ron O.
Published: July 2019

Allosteric modulators are highly desirable as drugs, particularly for G-protein-coupled receptor (GPCR) targets, because allosteric drugs can achieve selectivity between closely related receptors. The mechanisms by which allosteric modulators achieve selectivity remain elusive, however, particularly given recent structures that reveal similar allosteric binding sites across receptors. Here we show that positive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (mAChR) achieve exquisite selectivity by occupying a dynamic pocket absent in existing crystal structures. This cryptic pocket forms far more frequently in molecular dynamics simulations of the M1 mAChR than in those of other mAChRs. These observations reconcile mutagenesis data that previously appeared contradictory. Further mutagenesis experiments validate our prediction that preventing cryptic pocket opening decreases the affinity of M1-selective PAMs. Our findings suggest opportunities for the design of subtype-specific drugs exploiting cryptic pockets that open in certain receptors but not in other receptors with nearly identical static structures.
Two-step chromosome segregation in the stalked budding bacterium Hyphomonas neptunium
Authors: Jung Alexandra , Raßbach Anne , Pulpetta Revathi L. , van Teeseling Muriel C. F. , Heinrich Kristina , Sobetzko Patrick , Serrania Javier , Becker Anke , Thanbichler Martin
Published: July 2019

Chromosome segregation typically occurs after replication has finished in eukaryotes but during replication in bacteria. Here, we show that the alphaproteobacteriumHyphomonas neptunium, which proliferates by bud formation at the tip of a stalk-like cellular extension, segregates its chromosomes in a unique two-step process. First, the two sister origin regions are targeted to opposite poles of the mother cell, driven by the ParABSpartitioning system. Subsequently, once the bulk of chromosomal DNA has been replicated and the bud exceeds a certain threshold size, the cell initiates a second segregation step during which it transfers the stalk-proximal origin region through the stalk into the nascent bud compartment. Thus, while chromosome replication and segregation usually proceed concurrently in bacteria, the two processes are largely uncoupled inH. neptunium, reminiscent of eukaryotic mitosis. These results indicate that stalked budding bacteria have evolved specific mechanisms to adjust chromosome segregation to their unusual life cycle.
A standard for near-scarless plasmid construction using reusable DNA parts
Authors: Ma Xiaoqiang , Liang Hong , Cui Xiaoyi , Liu Yurou , Lu Hongyuan , Ning Wenbo , Poon Nga Yu , Ho Benjamin , Zhou Kang
Published: July 2019

Here we report GT (Guanin/Thymine) standard (GTS) for plasmid construction under which DNA sequences are defined as two types of standard, reusable parts (fragment and barcode). We develop a technology that can efficiently add any two barcodes to two ends of any fragment without leaving scars in most cases. We can assemble up to seven such barcoded fragments into one plasmid by using one of the existing DNA assembly methods, including CLIVA, Gibson assembly, In-fusion cloning, and restriction enzyme-based methods. Plasmids constructed under GTS can be easily edited, and/or be further assembled into more complex plasmids by using standard DNA oligonucleotides (oligos). Based on 436 plasmids we constructed under GTS, the averaged accuracy of the workflow was 85.9%. GTS can also construct a library of plasmids from a set of fragments and barcodes combinatorically, which has been demonstrated to be useful for optimizing metabolic pathways.
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome
Authors: Sarret Catherine , Ashkavand Zahra , Paules Evan , Dorboz Imen , Pediaditakis Peter , Sumner Susan , Eymard-Pierre Eléonore , Francannet Christine , Krupenko Natalia I. , Boespflug-Tanguy Odile , Krupenko Sergey A.
Published: July 2019

Neuro-ichthyotic syndromes are a group of rare genetic diseases mainly associated with perturbations in lipid metabolism, intracellular vesicle trafficking, or glycoprotein synthesis. Here, we report a patient with a neuro-ichthyotic syndrome associated with deleterious mutations in the ALDH1L2 (aldehyde dehydrogenase 1 family member L2) gene encoding for mitochondrial 10-formyltetrahydrofolate dehydrogenase. Using fibroblast culture established from the ALDH1L2-deficient patient, we demonstrated that the enzyme loss impaired mitochondrial function affecting both mitochondrial morphology and the pool of metabolites relevant to β-oxidation of fatty acids. Cells lacking the enzyme had distorted mitochondria, accumulated acylcarnitine derivatives and Krebs cycle intermediates, and had lower ATP and increased ADP/AMP indicative of a low energy index. Re-expression of functional ALDH1L2 enzyme in deficient cells restored the mitochondrial morphology and the metabolic profile of fibroblasts from healthy individuals. Our study underscores the role of ALDH1L2 in the maintenance of mitochondrial integrity and energy balance of the cell, and suggests the loss of the enzyme as the cause of neuro-cutaneous disease.
An unconventional uptake rate objective function approach enhances applicability of genome-scale models for mammalian cells
Authors: Chen Yiqun , McConnell Brian O. , Gayatri Dhara Venkata , Mukesh Naik Harnish , Li Chien-Ting , Antoniewicz Maciek R. , Betenbaugh Michael J.
Published: July 2019

Constraint-based modeling has been applied to analyze metabolism of numerous organisms via flux balance analysis and genome-scale metabolic models, including mammalian cells such as the Chinese hamster ovary (CHO) cells—the principal cell factory platform for therapeutic protein production. Unfortunately, the application of genome-scale model methodologies using the conventional biomass objective function is challenged by the presence of overly-restrictive constraints, including essential amino acid exchange fluxes that can lead to improper predictions of growth rates and intracellular flux distributions. In this study, these constraints are found to be reliably predicted by an “essential nutrient minimization” approach. After modifying these constraints with the predicted minimal uptake values, a series of unconventional objective functions are applied to minimize each individual non-essential nutrient uptake rate, revealing useful insights about metabolic exchange rates and flows across different cell lines and culture conditions. This unconventional uptake-rate objective functions (UOFs) approach is able to distinguish metabolic differences between three distinct CHO cell lines (CHO-K1, -DG44, and -S) not directly observed using the conventional biomass growth maximization solutions. Further, a comparison of model predictions with experimental data from literature correctly correlates with the specific CHO-DG44-derived cell line used experimentally, and the corresponding dual prices provide fruitful information concerning coupling relationships between nutrients. The UOFs approach is likely to be particularly suited for mammalian cells and other complex organisms which contain multiple distinct essential nutrient inputs, and may offer enhanced applicability for characterizing cell metabolism and physiology as well as media optimization and biomanufacturing control.
Publisher Correction: Effect of statins on the association between high temperature and all-cause mortality in a socioeconomically disadvantaged population: a cohort study
Authors: Nam Young Hee , Bilker Warren B. , Leonard Charles E. , Bell Michelle L. , Alexander Lacy M. , Hennessy Sean
Published: July 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Molecular simulation of efficient removal of H2S pollutant by cyclodextrine functionalized CNTs
Authors: Darvish Ganji Masoud , Kiyani Hadis
Published: July 2019

DFT-D3 calculations were carried out to investigate interaction of H2S and CH4 between numerous functionalized CNTs (f-CNTs), including hydroxyl, carboxyl, and cyclodextrin groups as potential candidates for selective adsorption and elimination of toxic pollutants. It was found that pristine CNTs as well as nanotube surface of functionalized CNTs cannot stably adsorb the H2S molecule (adsorption energy of −0.17 eV). However, H2S adsorption was significantly enhanced with different magnitudes upon the functionalization of CNT. For f-CNTs, H2S adsorption was accompanied by releasing energies in the range between −0.34 to −0.54 eV where the upper limit of this range belongs to the cyclodextrin-functionalized CNT (CD-CNT) as the consequence of the existence of both dispersion and electrostatic interactions between the adsorbate and substrate. Findings also demonstrated a significantly weaker interaction between CH4 and CD-CNT in comparison to the H2S molecule with adsorption energy of −0.14 eV. Electronic properties of the selected substrates revealed no significant changes in the inherent electronic properties of the CNTs after functionalizing and adsorbing the gas molecules. Moreover, DFTB-MD simulation demonstrated high adsorption capacity as well as CD-CNT ability for H2S molecules against the CH4 one under ambient condition.
Responses of plant growth, physiological, gas exchange parameters of super and non-super rice to rhizosphere temperature at the tillering stage
Authors: Li Shuying , Jiang Haolin , Wang Jianjun , Wang Yandong , Pan Shenggang , Tian Hua , Duan Meiyang , Wang Shuli , Tang Xiangru , Mo Zhaowen
Published: July 2019

Temperature is one of the critical factors affecting rice growth and yield production. This study investigated the effects of rhizosphere temperature at the tillering stage on the growth, physiological parameters and gas exchange attributes of two rice cultivars, i.e., the super rice cultivar Yuxiangyouzhan and the non-super rice cultivar Xiangyaxiangzhan, under hydroponic conditions. Three rhizosphere temperature treatments, i.e., a low-rhizosphere-temperature treatment (LT, nutrient solution at 17.5 ± 1.5 °C), an ambient-temperature treatment (AT, nutrient solution at 27.5 ± 1.5 °C), and a high-rhizosphere-temperature treatment (HT, nutrient solution at 37.5 ± 1.5 °C), were applied in this study. The results showed significant differences in most of the rice growth and physiological and gas exchange parameters as a result of cultivar and rhizosphere temperature as well as their interaction. In addition, the marked reduction in total dry weight was positively correlated with a notable reduction in plant morphological parameters, such as the fresh and dry weight of the leaves and stem sheaths, and changes in gas exchange parameters. Moreover, antioxidant reactions were active in response to high and low rhizosphere temperatures, which varied in different plant tissues. These results suggested that the super and non-super rice were sensitive to high and low rhizosphere temperatures, respectively.
Molecular Dynamics Study of the Changes in Conformation of Calmodulin with Calcium Binding and/or Target Recognition
Authors: Kawasaki Hiroshi , Soma Natsumi , Kretsinger Robert H.
Published: July 2019

Calmodulin is a calcium binding protein with two lobes, N-lobe and C-lobe, which evolved from duplication and fusion of a single precursor lobe of a pair of EF-hand. These two lobes of calmodulin show subtle differences in calcium binding and target recognition; these are important for the functions of calmodulin. Since the structures, especially main chain conformations, of two EF-lobes in holo-form are quite similar; this is a good example to evaluate the effect of side chains for structural dynamics. We analyzed the structure of calmodulin using molecular dynamics and found differences in conformational ensembles between N- and C-lobes. We also showed the mutant structures created by homology modeling could reproduce the difference of dynamic motion between N- and C-lobes.
Epigenetics, N-myrystoyltransferase-1 and casein kinase-2-alpha modulates the increased replication of HIV-1 CRF02_AG, compared to subtype-B viruses
Authors: Bhargavan Biju , Kanmogne Georgette D.
Published: July 2019

HIV subtypes distribution varies by geographic regions; this is likely associated with differences in viral fitness but the predictors and underlying mechanisms are unknown. Using in-vitro, in-vivo, and ex-vivo approaches, we found significantly higher transactivation and replication of HIV-1-CRF02_AG (prevalent throughout West-Central Africa), compared to subtype-B. While CRF02_AG-infected animals showed higher viremia, subtype-B-infected animals showed significantly more weight loss, lower CD4+ T-cells and lower CD4/CD8 ratios, suggesting that factors other than viremia contribute to immunosuppression and wasting syndrome in HIV/AIDS. Compared to HIV-1-subtype-B and its Tat proteins(Tat.B), HIV-1-CRF02_AG and Tat.AG significantly increased histone acetyl-transferase activity and promoter histones H3 and H4 acetylation. Silencing N-myrystoyltransferase(NMT)-1 and casein-kinase-(CK)-II-alpha prevented Tat.AG- and HIV-1-CRF02_AG-mediated viral transactivation and replication, but not Tat.B- or HIV-1-subtype-B-mediated effects. Tat.AG and HIV-1-CRF02_AG induced the expression of NMT-1 and CKII-alpha in human monocytes and macrophages, but Tat.B and HIV-1-subtype-B had no effect. These data demonstrate that NMT1, CKII-alpha, histone acetylation and histone acetyl-transferase modulate the increased replication of HIV-1-CRF02_AG. These novel findings demonstrate that HIV genotype influence viral replication and provide insights into the molecular mechanisms of differential HIV-1 replication. These studies underline the importance of considering the influence of viral genotypes in HIV/AIDS epidemiology, replication, and eradication strategies.
The heterogeneity in link weights may decrease the robustness of real-world complex weighted networks
Authors: Bellingeri M. , Bevacqua D. , Scotognella F. , Cassi D.
Published: July 2019

Here we report a comprehensive analysis of the robustness of seven high-quality real-world complex weighted networks to errors and attacks toward nodes and links. We use measures of the network damage conceived for a binary (e.g. largest connected cluster LCC, and binary efficiency Effbin) or a weighted network structure (e.g. the efficiency Eff, and the total flow TF). We find that removing a very small fraction of nodes and links with respectively higher strength and weight triggers an abrupt collapse of the weighted functioning measures while measures that evaluate the binary-topological connectedness are almost unaffected. These findings unveil a problematic response-state where the attack toward a small fraction of nodes-links returns the real-world complex networks in a connected but inefficient state. Our findings unveil how the robustness may be overestimated when focusing on the connectedness of the components only. Last, to understand how the networks robustness is affected by link weights heterogeneity, we randomly assign link weights over the topological structure of the real-world networks and we find that highly heterogeneous networks show a faster efficiency decrease under nodes-links removal: i.e. the robustness of the real-world complex networks against nodes-links removal is negatively correlated with link weights heterogeneity.
Infant brain activity in response to yawning using functional near-infrared spectroscopy
Authors: Tsurumi Shuma , Kanazawa So , Yamaguchi Masami K.
Published: July 2019

Yawning is contagious in human adults. While infants do not show contagious yawning, it remains unclear whether infants perceive yawning in the same manner as other facial expressions of emotion. We addressed this problem using functional near-infrared spectroscopy (fNIRS) and behavioural experiments. We confirmed behaviourally that infants could discriminate between yawning and unfamiliar mouth movements. Furthermore, we found that the hemodynamic response of infants to a yawning movement was greater than that to mouth movement, similarly to the observations in adult fMRI study. These results suggest that the neural mechanisms underlying yawning movement perception have developed in advance of the development of contagious yawning.
Smartphone-based colorimetric assay of antioxidants in red wine using oxidase-mimic MnO2 nanosheets
Authors: Li Yongfei , Zhang Pu , Fu Wensheng , Chen Lingli , Wu Shiyue , Long Yunfei , Wang Yi
Published: July 2019

A smartphone-based colorimetric method is developed for the determination of total antioxidants in red wine using oxidase-mimic MnO2 nanosheets as probes.
A new colitis therapy strategyviathe target colonization of magnetic nanoparticle-internalizedRoseburia intestinalis
Authors: Xiao Mengwei , Shen Zhaohua , Luo Weiwei , Tan Bei , Meng Xiangrui , Wu Xing , Wu Shuai , Nie Kai , Tong Ting , Hong Junbo , Wang Xiaolei , Wang Xiaoyan
Published: July 2019

Magnetic nano-assistedRoseburia intestinaliscontributes to the initiation and maintenance of the homeostasis process in the gut tissues.
PEG-conjugated pyrrole-based polymers: one-pot multicomponent synthesis and self-assembly into soft nanoparticles for drug delivery
Authors: Moquin Alexandre , Hanna Ramez , Liang Tongyue , Erguven Huseyin , Gran Evan Rizzel , Arndtsen Bruce A. , Maysinger Dusica , Kakkar Ashok
Published: July 2019

A simple one-pot methodology provides easy access to amphiphilic PEG–pyrrole backbone polymers, which self-assemble into soft nanoparticles enabling efficient drug loading/sustained release and can be detected inside cells.
Robust magnetic double-network hydrogels with self-healing, MR imaging, cytocompatibility and 3D printability
Authors: Gang Fangli , Yan Hao , Ma Chunyang , Jiang Le , Gu Yingying , Liu Ziyu , Zhao Lingyun , Wang Xiumei , Zhang Jiwen , Sun Xiaodan
Published: July 2019

A strategy to improve the strength and self-healing properties of magnetic hydrogels while conferring cytocompatibility and 3D printability.
Exploring through-bond and through-space magnetic communication in 1,3,2-dithiazolyl radical complexes
Authors: Leckie Dominique , Stephaniuk Nadia T. , Arauzo Ana , Campo Javier , Rawson Jeremy M.
Published: July 2019

Coordination of the dithiazolyl radical MBDTA leads to strong intramolecular metal–radical magnetic exchange but the strength of the intermolecular exchange coupling is strongly dependent on molecular packing.
A dopamine-induced Au hydrogel nanozyme for enhanced biomimetic catalysis
Authors: Jiao Lei , Xu Weiqing , Yan Hongye , Wu Yu , Gu Wenling , Li He , Du Dan , Lin Yuehe , Zhu Chengzhou
Published: July 2019

Due to porous nanostructure and polydopamine-induced interfacial electron transfer effects, Au hydrogel nanozyme exhibits enhanced glucose oxidase-like and peroxidase-like activities, with a biomimetic cascade catalysis.
A highly efficient, colorimetric and fluorescent probe for recognition of aliphatic primary amines based on a unique cascade chromophore reaction
Authors: Li Lanqing , Li Wenting , Ran Xueguang , Wang Lingyun , Tang Hao , Cao Derong
Published: July 2019

A highly efficient, colorimetric and fluorescent probe for recognition of aliphatic primary amines based on a unique cascade chromophore reaction is developed.
Two-dimensional heterometallic CuIILnIII (Ln = Tb and Dy) coordination polymers bridged by dicyanamides showing slow magnetic relaxation behavior
Authors: Kong Jiao-Jiao , Zhang Jia-Chen , Jiang Yu-Xuan , Tao Jin-Xia , Wang Wen-Yan , Huang Xing-Cai
Published: July 2019

Two-dimensional heterometallic CuIILnIII (Ln = Gd, Tb and Dy) coordination polymers bridged by dicyanamides showed slow magnetic relaxation behaviour and a magnetic hysteresis loop at 1.8 K was observed for the CuTb compound.
Molecular tectonics: enantiomerically pure chiral crystals based on trans-1,2-cyclohexanediol
Authors: Forquin Benjamin , Berthaud Julien , Jouaiti Abdelaziz , Kyritskas Nathalie , Ferlay Sylvie , Hosseini Mir Wais
Published: July 2019

Enantiomerically pure trans-1,2-cyclohexanediol ((R,R) or (S,S)) based organic ligands act self-complementary units. In addition, their coordination behavior towards Cd2+ cation in the presence of N donor ancillary ligand was investigated.
Replica exchange MD simulations of two-dimensional water in graphene nanocapillaries: rhombic versus square structures, proton ordering, and phase transitions
Authors: Li Shujuan , Schmidt Burkhard
Published: July 2019

Minimum energy structures of quasi-two dimensional ice confined between graphene sheets.
Polypyrrole derivatives for optoelectronic applications: a DFT study on the influence of side groups
Authors: Coleone Alex Pifer , Lascane Leonardo Gois , Batagin-Neto Augusto
Published: July 2019

DFT calculations were used to evaluate the effect of side groups on the structural, optical and electronic properties of 3-substituted PPy derivatives. Simple relationships between the optoelectronic properties and Hammet parameters are proposed.
Dynamics of impurity clustering in superfluid 4He nanodroplets
Authors: Coppens François , Ancilotto Francesco , Barranco Manuel , Halberstadt Nadine , Pi Martí
Published: July 2019

Snapshot taken at 75 ps of the capture of six Ar atoms hitting a 4He5000 droplet at 100 m s−1.
Ab initio spectroscopy of water under electric fields
Authors: Cassone Giuseppe , Sponer Jiri , Trusso Sebastiano , Saija Franz
Published: July 2019

IR and Raman spectra of bulk liquid water under intense electric fields reveal the contraction of both spectra and the onset of a novel high-frequency librational mode band. Moreover, the water structure evolves toward “ice-like” arrangements.
Pinpointing the active sites and reaction mechanism of CO oxidation on NiO
Authors: Wang Fang , Xu Yuxing , Liu Xingchen , Liu Ya , Liu Jie , Teng Botao
Published: July 2019

CO oxidation on NiO by different oxygen species was investigated using a global pathway searching method.
A comparative study on modeling of the ferromagnetic and paramagnetic states of uranium hydride using a DFT+U method
Authors: Jun KyuJung , Lee Jae-Uk , Chang Min Ho , Oda Takuji
Published: July 2019

We present a comprehensive DFT study on modeling of ferromagnetic and paramagnetic states of uranium hydride, which can facilitate the design of multiscale modeling of uranium hydride.
Ab initio study of a 2D h-BAs monolayer: a promising anode material for alkali-metal ion batteries
Authors: Khossossi Nabil , Banerjee Amitava , Benhouria Younes , Essaoudi Ismail , Ainane Abdelmajid , Ahuja Rajeev
Published: July 2019

The selection of a suitable two dimensional anode material is one of the key steps in the development of alkali metal ion batteries to achieve superior performance with an ultrahigh rate of charging/discharging capability.
Synthesis and structural characterization of 20-membered macrocyclic rings bearingtrans-chelating bis(N-heterocyclic carbene) ligands and the catalytic activity of their palladium(ii) complexes
Authors: Thapa Rajesh , Kilyanek Stefan M.
Published: July 2019

20-Membered macrocyclic rings containing NHCs and amines were synthesized, and their late metal coordination chemistry explored.
Synthetic and structural investigations of bis(N-alkyl-benzoselenadiazolium) cations
Authors: Lee Lucia Myongwon , Corless Victoria , Luu Helen , He Allan , Jenkins Hilary , Britten James F. , Adam Pani Faisal , Vargas-Baca Ignacio
Published: July 2019

A variety of supramolecular structures is formed by selenadiazolium cations linked by hydrocarbon bridges.
Luminescent twelve-nuclear rhenium clusters
Authors: Gayfulin Yakov M. , Brylev Konstantin A. , Ryzhikov Maxim R. , Samsonenko Denis G. , Kitamura Noboru , Mironov Yuri V.
Published: July 2019

A series of bioctahedral rhenium cluster compounds demonstrate red luminescence in both the solid phase and solution.
Preparation of monocarbonyl ruthenium complexes bearing bidentate nitrogen and phosphine ligands and their catalytic activity in carbonyl compound reduction
Authors: Giboulot Steven , Comuzzi Clara , Del Zotto Alessandro , Figliolia Rosario , Lippe Giovanna , Lovison Denise , Strazzolini Paolo , Susmel Sabina , Zangrando Ennio , Zuccaccia Daniele , Baldino Salvatore , Ballico Maurizio , Baratta Walter
Published: July 2019

A series of novel monocarbonyl ruthenium catalysts containing bidentate dinitrogen or/and diphosphine ligands are easily obtained through a general and straightforward approach.
Redefining the Robeson upper bounds for CO2/CH4 and CO2/N2 separations using a series of ultrapermeable benzotriptycene-based polymers of intrinsic microporosity
Authors: Comesaña-Gándara Bibiana , Chen Jie , Bezzu C. Grazia , Carta Mariolino , Rose Ian , Ferrari Maria-Chiara , Esposito Elisa , Fuoco Alessio , Jansen Johannes C. , McKeown Neil B.
Published: July 2019

Ultrapermeable benzotriptycene-based PIMs show exceptional gas selectivities that define new positions for the CO2/CH4 and CO2/N2 Robeson upper bounds.
Correction: Star-shaped π-gelators based on oxadiazole and thiadiazoles: a structure–property correlation
Authors: Nath Subrata , Pathak Suraj Kumar , De Joydip , Pal Santanu Kumar , Achalkumar Ammathnadu S.
Published: July 2019

Correction for ‘Star-shaped π-gelators based on oxadiazole and thiadiazoles: a structure–property correlation’ by Subrata Nath et al., Mol. Syst. Des. Eng., 2017, 2, 478–489.
Single-crystal X-ray diffraction study, NMR and electrochemical analysis of a copper(i) 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis-[(6-methyl-2,2′-bipyridyl-6-yl)methoxy]calix[4]arene complex: an original M4L2“hand-to-hand” system
Authors: Regnouf-de-Vains J.-B. , Malaman B. , Bouguet-Bonnet S. , Poinsignon Sophie , Leclerc Sébastien , Beley M.
Published: July 2019

An original M4L2“hand-to-hand” copper(i)/tetra-bipyridyl-calix[4]arene complex was obtained and characterized in the solid state by X-ray diffraction. It changes in MeCN solution to its M2L analogue.
Novel acrylamide/acrylonitrile-tethered carbazoles: synthesis, structural, biological, and density functional theory studies
Authors: Padmavathy Krishnaraj , Krishnan Kannan Gokula , Kumar Chandran Udhaya , Sathiyaraj Ethiraj , Sivaramakarthikeyan Ramar , Lim Wei-Meng , Mai Chun-Wai , Ramalingan Chennan
Published: July 2019

The design and synthesis of novel carbazole-based heterocyclic chemical entities as anticancer agents were accomplished.
A study of the cis–trans isomerization preference of N-alkylated peptides containing phosphorus in the side chain and backbone
Authors: de la Torre Alexander F. , Ali Akbar , Concepcion Odette , Montero-Alejo Ana L. , Muñiz Francisco M. , Jiménez Claudio A. , Belmar Julio , Velázquez-Libera José Luis , Hernández-Rodríguez Erix W. , Caballero Julio
Published: July 2019

The current work provides a study on the cis–trans isomerization behaviour of N-alkylated peptides decorated with phosphonate ester groups.
NHC-catalyzed green synthesis of functionalized chromones: DFT mechanistic insights andin vitroactivities in cancer cells
Authors: Murugesh Nithya , Haribabu Jebiti , Arumugam Krishnamoorthy , Balachandran Chandrasekar , Swaathy Rajagopal , Aoki Shin , Sreekanth Anandaram , Karvembu Ramasamy , Vedachalam Seenuvasan
Published: July 2019

A simple green protocol for the synthesis of 3-aminochromone derivatives using a NHC catalyzed intramolecular hydroacylation reaction was developed. Further functional 3-aminochromes were evaluated for their anticancer activity.
Pd/meso-CoO derived from in situ reduction of the one-step synthesized Pd/meso-Co3O4: high-performance catalysts for benzene combustion
Authors: Zhao Xingtian , Zhang Ran , Liu Yuxi , Deng Jiguang , Xu Peng , Lv Sijie , Li Shuang , Pei Wenbo , Zhang Kunfeng , Dai Hongxing
Published: July 2019

The 0.93Pd/meso-CoO is prepared via in situ reduction of 0.85Pd/meso-Co3O4 derived from KIT-6-templating method. The excellent catalytic activity of 0.93Pd/meso-CoO is related to the formed Pd0 species and good oxygen activation ability.
Synthesis and coordination properties of new σ2,λ3-P/N switchable chelators based on [1,2,3]-diazaphosphole
Authors: Kozáček Pavel , Dostál Libor , Růžička Aleš , Císařová Ivana , Černošek Zdeněk , Erben Milan
Published: July 2019

New ligands with σ2,λ3-P/N switching ability were synthesised and their coordination properties toward transition metals were studied.
An rGQD/chitosan nanocomposite-based pH-sensitive probe: application to sensing in urease activity assays
Authors: Shi Fanping , Shang Danyi , Wang Zonghua
Published: July 2019

We used the intriguing pH-responsive protonation/deprotonation transitions of chitosan and the fluorescence properties of reduced graphene quantum dots to design a novel pH probe and realize the real-time monitoring of urease activity.
Electrohydrodynamic 3D printing of layer-specifically oriented, multiscale conductive scaffolds for cardiac tissue engineering
Authors: Lei Qi , He Jiankang , Li Dichen
Published: July 2019

Here a novel strategy was presented to fabricate multiscale conductive scaffolds with layer-specific fiber orientations for cardiac tissue engineering by combining solution-based and melt-based electrohydrodynamic (EHD) printing techniques.
Construction and carbon dioxide capture of microporous polymer networks with high surface area based on cross-linkable linear polyimides
Authors: Song Ningning , Wang Tianjiao , Yao Hongyan , Ma Tengning , Shi Kaixiang , Tian Ye , Zou Yongcun , Zhu Shiyang , Zhang Yunhe , Guan Shaowei
Published: July 2019

Microporous polyimide networks with high surface area and excellent CO2 adsorption performance have been constructed based on cross-linkable linear polyimides through crosslinking reaction.
Aziridine-based polyaddition, post-modification, and crosslinking: can aziridine rival epoxide in polymer chemistry?
Authors: Jung Sangmin , Kang Seohyun , Kuwabara Junpei , Yoon Hyo Jae
Published: July 2019

Aziridine may help to solve the problems encountered in epoxide-based polymer technologies. This review focuses on recent achievements in aziridine-based polyaddition, post-modification, and cross-linking.
Catalyst shuttling enabled by a thermoresponsive polymeric ligand: facilitating efficient cross-couplings with continuously recyclable ppm levels of palladium
Authors: Wang Erfei , Chen Mao
Published: July 2019

A thermoresponsive polymeric Pd-complex was synthesized, enabling highly efficient cross-couplings and continuous catalyst-recycling flow reactions with ultralow Pd usages.
Quincke rotor dynamics in confinement: rolling and hovering
Authors: Pradillo Gerardo E. , Karani Hamid , Vlahovska Petia M.
Published: July 2019

We experimentally investigate the influence of strong confinement and the conductivity-control surfactant AOT on the Quincke effect (spontaneous spinning of a dielectric sphere in a uniform electric field.)
Can one determine the density of an individual synthetic macromolecule?
Authors: Messmer Daniel , Sánchez-Ferrer Antoni , Tacke Sebastian , Yu Hao , Nüsse Harald , Klingauf Jürgen , Wepf Roger , Kröger Martin , Halperin Avraham , Mezzenga Raffaele , Schlüter A. Dieter
Published: July 2019

The determination of volumetric mass densities of dendronized polymers was attempted, utilizing the measurable physical dimensions these synthetic molecular objects possess.
Hepatoprotective effect of essential oils of Nepeta cataria L. on acetaminophen-induced liver dysfunction
Authors: Tan Juan , Li Jing , Ma Jilei , Qiao Feng
Published: July 2019

Nepeta cataria L. has long been used in folk food and medicine for several functions. Essential oils (EOs) were extracted from Nepeta cataria L. by supercritical fluid extraction. The results of animal experiments showed that EOs from Nepeta cataria L. significantly attenuated acetaminophen-induced liver damage. Further study confirmed that EOs were able to increase mRNA expression of uridine diphosphate glucuronosyltransferases (UGTs) and sulfotransferases (SULTs), as well as inhibit CYP2E1 activities, and thereby suppressed toxic intermediate formation. Nrf-2 activation might be involved in EOs-induced up-regulation of Phase II enzymes. Collectively, our data provide evidence that EOs protect the liver against acetaminophen-induced liver injury mainly by accelerating acetaminophen harmless metabolism, implying that EOs can be considered as a potential natural resource to develop hepatoprotective agent.
Lexical Diversity Versus Lexical Error in the Language Transcripts of Children With Developmental Language Disorder: Different Conclusions About Lexical Ability
Authors: Charest Monique , Skoczylas Melissa J.
Published: July 2019

Purpose

The purpose of this study was to provide preliminary data on differences in lexical diversity and lexical-semantic errors in the language samples of children with developmental language disorder (DLD) and children with typical language development (TLD) of the same age.

Method

We analyzed word use in the narrative transcripts of children with DLD and TLD (
N
= 14;
M
age
= 6;8 [years;months]) using standard measures of lexical diversity (number of different words, moving-average type–token ratio) and additional counts of lexical-semantic errors.

Results

There were no significant differences between the groups in lexical diversity, and all children with DLD scored within the age-appropriate range on diversity relative to a normative sample. The children with DLD, however, produced significantly more lexical errors than their TLD peers.

Conclusions

The results suggest that caution is warranted when interpreting normal-range lexical diversity scores in children with DLD, as children with DLD may demonstrate functional difficulties with word use that are not captured by lexical diversity measures. A focus on lexical errors holds promise for characterizing lexical-semantic qualities of language transcripts that are not captured by standard measures of diversity. Development of a reliable clinical system for coding and characterizing lexical-semantic errors in language transcripts is warranted.
Taste Manipulation and Swallowing Mechanics in Trauma-Related Sensory-Based Dysphagia
Authors: Dietsch Angela M. , Dorris H. Duncan , Pearson William G. , Dietrich-Burns Katie E. , Solomon Nancy Pearl
Published: July 2019

Purpose

This study explored the effects of high-concentration taste manipulation trials on swallow function in persons with sensory-based dysphagia.

Method

Dysphagia researchers partnered with clinical providers to prospectively identify traumatically injured U.S. military service members (
N
= 18) with sensory-based dysphagia as evidenced by delayed initiation and/or decreased awareness of residue/penetration/aspiration. Under videofluoroscopy, participants swallowed trials of 3 custom-mixed taste stimuli: unflavored (40% weight/volume [wt/vol] barium sulfate in distilled water), sour (2.7% wt/vol citric acid in 40% wt/vol barium suspension), and sweet–sour (1.11% wt/vol citric acid plus 8% wt/vol sucrose in 40% wt/vol barium suspension). Trials were analyzed and compared via clinical rating tools (the Modified Barium Swallow Impairment Profile [
Martin-Harris et al., 2008
] and the Penetration-Aspiration Scale [
Rosenbek, Robbins, Roecker, Coyle, & Wood, 1996
]). Additionally, a computational analysis of swallowing mechanics (CASM) was applied to a subset of 9 swallows representing all 3 tastants from 3 participants.

Results

Friedman's tests for the 3 stimuli revealed significantly (
p
< .05) improved functional ratings for Penetration-Aspiration Scale and pharyngoesophageal opening. CASM indicated differences in pharyngeal swallowing mechanics across all tastant comparisons (
p
≤ .0001). Eigenvectors revealed increased tongue base retraction, hyoid elevation, and pharyngeal shortening for sweet–sour and, to a lesser extent, sour than for unflavored boluses.

Conclusion

Advantageous changes in certain parameters of oropharyngeal swallowing physiology were noted with high-intensity tastants per both clinical ratings and subsequent CASM, suggesting potential therapeutic application for taste manipulation.
Common‐mode rejection ratio characterisation of a broadband electro‐optical differential ESD voltage probe
Authors: Štimac H. , Gillon R. , Barić A.
Published: July 2019

The concept of an isolated differential voltage measurement system is presented. The proposed probe circuit is designed for broadband measurement of electrostatic discharge (ESD) waveforms. The electro‐optical conversion of the measured signal allows the system to operate in an electromagnetically polluted environment. The signal capture and signal processing stages of the system are separated. Characteristics of the system in terms of differential‐mode and common‐mode signal sensing are discussed. The common‐mode rejection ratio (CMRR) of the system is explored in the gigahertz frequency range. Given the low cost, the system can be implemented both as a standalone probe or as a part of an integrated circuit characterisation and test environment.
Mutual coupling compensation for antenna arrays using the theory of characteristic modes
Authors: Lou Shunxi , Wang Wei
Published: July 2019

The mutual coupling effect is one of the most important factors that cannot be neglected in the analysis and synthesis of antenna arrays. In this Letter, a compensation method for the mutual coupling effect is proposed using the theory of characteristic modes, in which the mutual coupling effect is characterised from the perspective of modal coupling between different radiating elements. A compensation matrix is constructed, which makes the modal excitation coefficients of each radiating element in an array environment equal to those obtained without considering the mutual coupling effect. Numerical results demonstrate the effectiveness of the proposed method.
Low-grade myofibroblastic sarcoma: a case report of a child
Authors: Hamon Julien , Bourkis Amélie , Le Toux Guy
Published: July 2019

Introduction: Myofibroblastic sarcomas are malignant tumors characterized by the increased proliferation of myofibroblasts; they are rare and have been recently discovered. Observation: A 14-year-old adolescent had a large lesion in the inside of her right mandible. The diagnosis, after a difficult histological analysis, was low-grade myofibrosarcoma. The patient was treated with non-interruptive hemimandibulectomy. Discussion: Low-grade myofibroblastic sarcoma is one of four types of myofibroblastic sarcomas recognized by the WHO in the 2001 classification. This classification allows us to determine a prognosis based on histological characteristics of the lesion. Conclusion: In all cases of low-grade myofibroblastic sarcoma, the preferred treatment is curative surgical resection; but still poses a problem in the prosthetic rehabilitation of oral lesion.