bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and validation of a predictive model for febrile seizures
Authors: Cheng Anna , Xiong Qin , Wang Jing , Wang Renjian , Shen Lei , Zhang Guoqin , Huang Yujuan
Published: October 2023

Febrile seizures (FS) are the most prevalent type of seizures in children. Existing predictive models for FS exhibit limited predictive ability. To build a better-performing predictive model, a retrospective analysis study was conducted on febrile children who visited the Children's Hospital of Shanghai from July 2020 to March 2021. These children were divided into training set (n = 1453), internal validation set (n = 623) and external validation set (n = 778). The variables included demographic data and complete blood counts (CBCs). The least absolute shrinkage and selection operator (LASSO) method was used to select the predictors of FS. Multivariate logistic regression analysis was used to develop a predictive model. The coefficients derived from the multivariate logistic regression were used to construct a nomogram that predicts the probability of FS. The calibration plot, area under the receiver operating characteristic curve (AUC), and decision curve analysis (DCA) were used to evaluate model performance. Results showed that the AUC of the predictive model in the training set was 0.884 (95% CI 0.861 to 0.908, p < 0.001) and C-statistic of the nomogram was 0.884. The AUC of internal validation set was 0.883 (95% CI 0.844 to 0.922, p < 0.001), and the AUC of external validation set was 0.858 (95% CI 0.820 to 0.896, p < 0.001). In conclusion, the FS predictive model constructed based on CBCs in this study exhibits good predictive ability and has clinical application value.
Negative association between multiple sclerosis immunogenetic profile and in silico immunogenicities of 12 viruses
Authors: James Lisa M. , Georgopoulos Apostolos P.
Published: October 2023

Human Leukocyte Antigen (HLA) is involved in both multiple sclerosis (MS) and immune response to viruses. Here we investigated the virus-HLA immunogenicity (V-HLA) of 12 viruses implicated in MS with respect to 17 HLA Class I alleles positively associated to MS prevalence in 14 European countries. Overall, higher V-HLA immunogenicity was associated with smaller MS-HLA effect, with human herpes virus 3 (HHV3), JC human polyoma virus (JCV), HHV1, HHV4, HHV7, HHV5 showing the strongest association, followed by HHV8, HHV6A, and HHV6B (moderate association), and human endogenous retrovirus (HERV-W), HHV2, and human papilloma virus (HPV) (weakest association). These findings suggest that viruses with proteins of high HLA immunogenicity are eliminated more effectively and, consequently, less likely to be involved in MS.
How being perceived to be an artist boosts feelings of attraction in others
Authors: Wassiliwizky Eugen , Wontorra Paul , Ullén Fredrik
Published: October 2023

Music production is a universal phenomenon reaching far back into our past. Given its ubiquity, evolution theorists have postulated adaptive functions for music, such as strengthening in-group cohesion, intimidating enemies, or promoting child bonding. Here, we focus on a longstanding Darwinian hypothesis, suggesting that music production evolved as a vehicle to display an individual’s biological fitness in courtship competition, thus rendering musicality a sexually selected trait. We also extend this idea to visual artists. In our design, we employed different versions of naturalistic portraits that manipulated the presence or absence of visual cues suggesting that the person was an artist or a non-artist (e.g., farmer, teacher, physician). Participants rated each portrayed person’s appeal on multiple scales, including attractiveness, interestingness, sympathy, and trustworthiness. Difference scores between portrait versions revealed the impact of the artistic/non-artistic visual cues. We thus tested Darwin’s hypothesis on both a within-subject and within-stimulus level. In addition to this implicit approach, we collected explicit ratings on the appeal of artists versus non-artists. The results demonstrate divergent findings for both types of data, with only the explicit statements corroborating Darwin’s hypothesis. We discuss this divergence in detail, along with the particular role of interestingness revealed by the implicit data.
CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines
Authors: Witz Andréa , Dardare Julie , Francois Aurélie , Husson Marie , Rouyer Marie , Demange Jessica , Merlin Jean-Louis , Gilson Pauline , Harlé Alexandre
Published: October 2023

Pancreatic cancer is one of the most aggressive diseases with a very poor outcome. Olaparib, a PARP inhibitor, as maintenance therapy showed benefits in patients with metastatic pancreatic adenocarcinoma bearing germline BRCA1/2 mutations. However, germline BRCA mutation has been described in only 4–7% of patients with pancreatic adenocarcinoma. A CRISPR/Cas9-mediated system was used to knock-in the c.763G > T p.(Glu255*) and c.2133C > A p.(Cys711*) mutations in cell lines to obtain truncated BRCA1 and BRCA2 proteins, respectively. A CRISPR/Cas9 ribonucleoprotein complex was assembled for each mutation and transfected into two pancreatic cell lines (T3M4 and Capan-2) and into a breast cancer cell lines (MCF7) as control. BRCA protein levels were significantly decreased in all BRCA-depleted cells (P < 0.05), proving the transfection efficiency of our CRISPR/Cas9 systems. As expected, the calculated olaparib IC50 were significantly reduced for all cell lines harbored BRCA1 or BRCA2 mutations compared to wild-type BRCA1/2 cells (P < 0.01). Furthermore, we observed a higher induction of apoptosis after 72 h olaparib treatment in BRCA-depleted cells than in wild-type cells. This strategy might offer new insights into the management of patients with pancreatic cancer and open up new perspectives based on the in vivo use of CRISPR/Cas9 strategy.
Identification and validation of novel prognostic signatures based on m5C methylation patterns and tumor EMT profiles in head and neck squamous cell carcinoma
Authors: Zhu Guanghao , Wang Wei , Yao Hui , Li Haopu , Zhang Caiyun , Meng Yindi , Wang Jingjie , Zhu Minhui , Zheng Hongliang
Published: October 2023

The role of 5-methylcytosine (m5C) in tumor initiation and progression has been increasingly recognized. However, the precise association between the regulation of m5C and the progression, metastasis, and prognosis of head and neck squamous cell carcinoma (HNSCC) has not yet been fully explored. Data from 545 HNSCC patients obtained from The Cancer Genome Atlas (TCGA) database were analyzed. Unsupervised cluster analysis was conducted using the expression levels of m5C regulatory genes. Additionally, gene set variation analysis (GSVA), single-sample gene set enrichment analysis (ssGSEA), and Cox regression analysis were utilized. Quantitative reverse transcription polymerase chain reaction (RT-qPCR), colony formation assay, transwell experiments and western blots were performed in the HNSCC cell line UM-SCC-17B to assess the expression and functional role of one of the novel signatures, CNFN. Significant expression differences were found in m5C regulatory genes between tumor and normal tissues in HNSCC. Two distinct m5C modification patterns, characterized by substantial prognostic differences, were identified. Cluster-2, which exhibited a strong association with epithelial-mesenchymal transition (EMT), was found to be associated with a poorer prognosis. Based on the m5C clusters and EMT status, differentially expressed genes (DEGs) were identified. Using DEGs, an 8-gene signature (CAMK2N1, WNT7A, F2RL1, AREG, DEFB1, CNFN, TGFBI, and CAV1) was established to develop a prognostic model. The performance of this signature was validated in both the training and external validation datasets, demonstrating its promising efficacy. Furthermore, additional investigations using RT-qPCR on clinical specimens and experimental assays in cell lines provided compelling evidence suggesting that CNFN, one of the genes in the signature, could play a role in HNSCC progression and metastasis through the EMT pathway. This study highlighted the role of m5C in HNSCC progression and metastasis. The relationship between m5C and EMT has been elucidated for the first time. A robust prognostic model was developed for accurately predicting HNSCC patients’ survival outcomes. Potential molecular mechanisms underlying these associations have been illuminated through this research.
Dynamic financial and monetary security risk assessment based on information service security assessment model and blockchain
Authors: Li Jia
Published: October 2023

With the rapid development of blockchain technology, the financial and monetary (FM) blockchain fields also began to collide. Therefore, this study aims to explore the relationship between the two fields and efficiently evaluate the security of financial information. Firstly, this study introduces the theoretical basis of blockchain in the dynamic linkage mechanism of FM and gives the overall framework of digital currency based on blockchain. Meanwhile, the relationship between blockchain and digital finance is empirically analyzed and designed. Secondly, the framework of financial information service security assessment (ISSA) is created using blockchain technology, and the frame of security risk evaluation is verified by taking electronic invoice information as the research object. Finally, the results show that: (1) foreign exchange (forex) events and major stock index decline events have a significant impact on the return of Bitcoin (BTC) in the short term. Moreover, more than 70% of uncertainty events will make BTC’s abnormal return (AR) significantly positive; (2) Under the influence of forex uncertainty events, only one BTC’s AR is remarkably negative in short order, while the other seven times are markedly positive. In the uncertainty events of major stock indexes, only two times are significantly negative, and the other six times are positive. This indicates that uncertain events in the short run make prominent AR of BTC; the proposed blockchain-based ISSA model and assessment index are scientific, feasible, and operable.
Finite-element-analysis of connection strength of assembled camshafts with different cam-bore profiles using tube hydroforming technology
Authors: Ma Jianping , Jiang Zhansi , Lei Ji , Huang Jinjie , Liu Jun , Yang Lianfa , Wang Haijian , Rong Jianfeng
Published: October 2023

The assembled camshaft is a novel manufacturing product which connects the cam and the mandrel by tube hydroforming (THF) technology after they are processed separately. However, in the process of THF, the structure of the cam-bores has a crucial influence on the connection strength of the assembled camshafts. Therefore, three kinds of cam-bores with circular structure, isometric-trilateral profile and logarithmic spiral profile are selected for hydroforming with a hollow mandrel (tube) in this study. The finite-element-analysis is carried out by ABAQUS software, the variations of (residual) contact pressure and contact area under different structures are obtained, and the torsional angle variations after assembly are measured. Further, the connection strength of the assembled camshaft under three structures is discussed. The results show that the evaluation of connection strength of the assembled camshaft is affected by many factors, including contact pressure, maximum residual contact pressure, axial and circular residual contact pressure, contact area and its rate, residual contact area percentage and torsional angle. Through the comprehensive analysis of various factors, the torsional angle of the camshaft with circular structure is the largest, i.e. poor connection strength. By contrast, the torsional strength of the camshaft with isometric-trilateral profile is the largest, namely, the best connection strength.
Differences in non-communicable diseases between women in prison and the general population in Brazil
Authors: Leal Marto , Kerr Ligia , Mota Rosa Maria Salani , da Justa Pires Neto Roberto , Seal David , Kendall Carl
Published: October 2023

Women in prison have high risk for non-communicable diseases both in relation to men in prison and in relation to women in the general population. This study documented the health disparities related to diseases among women in prison and in the general female population in Brazil. Women in prisons (WP) < 30 years old had a prevalence of hypertension (PR = 4.5; 95% CI 3.4–6.1), cardiovascular disease (PR = 4.4; 95% CI 2.4–7.9) and asthma (PR = 3.0; 95% CI 2.3–3.8) higher than general female population in Brazil in the same age group. Women in prison > 50 years old also presented asthma prevalence (PR = 4.3; 95% CI 2.9–6.3) higher than the general female population in Brazil in the same age group. These women in prison, overwhelmingly young, could be mistaken for an elderly population in Brazil. Actively responding to early disease in these women can reduce overall health costs and improve health care for this population that may have limited access to health care outside of prison.
Early-life origin of prostate cancer through deregulation of miR-206 networks in maternally malnourished offspring rats
Authors: Portela Luiz M. F. , Constantino Flavia B. , Camargo Ana C. L. , Santos Sérgio A. A. , Colombelli Ketlin T. , Fioretto Matheus N. , Barata Luísa A. , Silva Erick J. R. , Scarano Wellerson R. , Felisbino Sergio L. , Moreno Carlos S. , Justulin Luis A.
Published: October 2023

The Developmental Origins of Health and Disease (DOHaD) concept has provided the framework to assess how early life experiences can shape health and disease throughout the life course. While maternal malnutrition has been proposed as a risk factor for the developmental programming of prostate cancer (PCa), the molecular mechanisms remain poorly understood. Using RNA-seq data, we demonstrated deregulation of miR-206-Plasminogen (PLG) network in the ventral prostate (VP) of young maternally malnourished offspring. RT-qPCR confirmed the deregulation of the miR-206-PLG network in the VP of young and old offspring rats. Considering the key role of estrogenic signaling pathways in prostate carcinogenesis, in vitro miRNA mimic studies also revealed a negative correlation between miR-206 and estrogen receptor α (ESR1) expression in PNT2 cells. Together, we demonstrate that early life estrogenization associated with the deregulation of miR-206 networks can contribute to the developmental origins of PCa in maternally malnourished offspring. Understanding the molecular mechanisms by which early life malnutrition affects offspring health can encourage the adoption of a governmental policy for the prevention of non-communicable chronic diseases related to the DOHaD concept.
Pristine gelatin incorporation as a strategy to enhance the biofunctionality of poly(vinyl alcohol)-based hydrogels for tissue engineering applications
Authors: Longoni Alessia , Major Gretel S. , Jiang Shaoyuan , Farrugia Brooke L. , Kieser David C. , Woodfield Tim B. F. , Rnjak-Kovacina Jelena , Lim Khoon S.
Published: October 2023

In this study, we investigated the suitability of pristine gelatin to enhance the biofunctionality of tyraminated PVA hydrogels, by promoting cell infiltration and host blood vessel recruitment in vitro and in vivo for tissue engineering applications.
Design of an apoptotic cell-mimetic wound dressing using phosphoserine–chitosan hydrogels
Authors: Lee Gyeongwoo , Nabil Ahmed , Kwon Oh Hyeong , Ebara Mitsuhiro
Published: October 2023

Phosphoserine-immobilized chitosan hydrogels stimulate macrophages to secrete TGF-β1 and improve diabetic wound healing equivalent to non-diabetic wound healing.
Double-stranded metallo-triangles: from anion-templated nonanuclear to cation-templated tetraicosanuclear dysprosium clusters
Authors: Liu Yanan , Sun Xiao , Chen Peiqiong , Li Xiaojuan , Huang Fu-Ping , Liu Hou-Ting , Tian Haiquan
Published: October 2023

Two double-stranded metallo-triangles, Dy9 and Dy24 were constructed. Compared with the field-induced relaxation phenomenon of Dy9 templated with a chloride anion, Dy24 templated with a sodium cation exhibited zero-field SMM behaviour.
Understanding activity diversity among Ni-based chalcogenide pre-catalysts under oxygen evolution conditions: the role of oxyanions
Authors: Xu Haoxiang , Li Kai , Liu Ning , Xia Wei , Liu Wenhao , Cao Dong , Zhang Lipeng , Cheng Daojian
Published: October 2023

The OER activity diversity among Ni-based chalcogenides is related to the in situ-formed oxyanions from anions.
Reversing Mg suppression effect on Co-site water oxidation of MgCo2O4 based on vanadium-atom electronic affinity synergy with Mg sites toward electronic redistribution
Authors: Zhang Hui , Han Hui , Yang Xuan , Ma Hongyu , Song Zhifei , Ji Xuqiang
Published: October 2023

Vanadium-doping-tailored MgCo2O4 coupled with MgO (V–MgCo2O4@MgO) exhibits significantly reinforced OER performance, with low overpotentials of 240 and 290 mV for 100 and 500 mA cm−2, respectively, in 1 M KOH.
General synthesis of carbon-guarded cobalt-based nanospheres for oxygen reduction electrocatalysis
Authors: Niu Shaoyang , Wei Sisi , Yue Dandan , Cai Yezheng , Ma Zhaoling , Liu Kui , Huang Youguo , Wang Hongqiang , Li Qingyu , Ye Tian-Nan
Published: October 2023

We construct carbon-guarded cobalt-based nanospheres composed of metal nanoparticles encased in a nitrogen doped carbon shell (M@NC NP), as efficient ORR catalysts.
In situ preparation of MOF-derived Fe2O3 nanorods for visible-light-driven oxygen evolution
Authors: Wu Heng , Lai Longjie , Li Zhengdao , Hu Jiyue , Zhang Li , Younas Waqar , Liu Qi
Published: October 2023

Fe2O3 nanorods were in situ synthesized in ambient air at room temperature by oxidation of Fe-based MOFs, which possess a high photocurrent density up to 0.11 mA cm−2 and exhibit an outstanding oxygen evolution rate efficiency of 55.2 μmol g−1 h−1.
Exploring second coordination sphere effects in flavodiiron nitric oxide reductase model complexes
Authors: Bracken Abigail J. , Dong Hai T. , Lengel Michael O. , Lehnert Nicolai
Published: October 2023

In this paper, we explore the role of SCS H-bonding interactions in the activation of NO by diiron complexes. Diferrous dinitrosyl complexes were prepared and spectroscopically characterized, and their reactivity upon reduction was investigated.
Confining redox-active metal sites in acidic porous scaffolds for the catalytic transformation of lignin-derived phenols to naphthenes
Authors: Li Hang , Chen Guan-Ze , Wu Chuan-De
Published: October 2023

A porous metal silicate (PMS) material, PMS-36, exhibits high efficiency and stability in catalyzing the hydrodeoxygenation transformation of lignin-derived phenols to naphthenes under mild conditions.
Micro- and nanostructured layered-kagome zinc orthovanadate BaZn3(VO4)2(OH)2
Authors: Hadrane Bachchar , Deniard Philippe , Gautier Nicolas , Paris Michael , Payen Christophe , Dessapt Rémi
Published: October 2023

Micro- and nanostructured layered-kagome zinc orthovanadate BaZn3(VO4)2(OH)2, the zinc analogue of copper mineral vesignieite, has been synthesised and characterised. Nanostructuring impacts the local structure and the optical properties.
Colloidal stabilization of hydrophobic InSe 2D nanosheets in a model environmental aqueous solution and their impact on Shewanella oneidensis MR-1
Authors: Sengupta Shreyasi , Ambade Swapnil B. , O'Keefe Tana L. , Tawakalna Falak , Hedlund Orbeck Jenny K. , Hamers Robert J. , Feng Z. Vivian , Haynes Christy L. , Rosenzweig Zeev
Published: October 2023

Exposure of InSe-EGCG to Shewanella oneidensis MR-1 decreases cell growth.
Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking
Authors: Hennessy Joseph , Klimkowski Piotr , Singleton Daniel , Gibney Alex , Coche Malou , Farrell Nicholas P. , El-Sagheer Afaf H. , Brown Tom , Kellett Andrew
Published: October 2023

We report a new class of carboplatin-TFO hybrid that incorporates a bifunctional alkyne–amine nucleobase monomer called AP-C3-dT that enables dual ‘click’ platinum(ii) drug conjugation and thiazole orange fluorophore coupling.
Precise and selective macroscopic assembly of a dual lock-and-key structured hydrogel
Authors: Heo Eunseok , Hwang Wooseop , Koo Hye Been , Park Steve , Kim Do-Nyun , Kim Ho-Young , Kim YongJoo , Chang Jae-Byum
Published: October 2023

In this work, we introduce dual lock-and-key structures for highly selective and precise macroscopic assembly of hydrogel building blocks. This work demonstrates diverse assembly ranging from simple to complex structures.
Porous SnO2 nanosheets for room temperature ammonia sensing in extreme humidity
Authors: Verma Mohit , Bahuguna Gaurav , Singh Sukhwinder , Kumari Ankita , Ghosh Dibyajyoti , Haick Hossam , Gupta Ritu
Published: October 2023

2D SnO2 nanosheets based chemiresistive sensor with microporosity and oxygen rich-surface detects ammonia at room temperature in extreme humidity at ppb levels for breath based early disease diagnostics and healthcare.
Photocatalytic activation of peroxodisulfate using iron-containing MOFs synthesized by single-crystal-to-single-crystal transformation for ofloxacin degradation
Authors: Zhang Hao , Chen Feng-Yu , Liu Zhi-Yong , Luo Yu-Hui , Zhou Zi-Lin , Jia Xue-Meng , Wang Xin , Yang Yun-Qiong
Published: October 2023

A new Fe-MOF with a large crystal size was synthesized through a single-crystal-to-single-crystal transformation method, and was developed as a photocatalyst for the activation of peroxodisulfate to degrade ofloxacin.
Modulating the antibacterial activity of a CuO@HKUST-1 nanocomposite by optimizing its synthesis procedure
Authors: Arshadi Edlo Afsaneh , Akhbari Kamran
Published: October 2023

HKUST-1 and [Cu(CH3COO)2·H2O]0.47@HKUST-1 were heated at 295 °C and 290 °C under N2 to produce [CuO]0.87@HKUST-1 and [CuO]0.65@HKUST-1, respectively. [CuO]0.87@HKUST-1 exhibits superior antibacterial activity, attributed to its increased Cu2+ ion release compared with [CuO]0.65@HKUST-1.
Pore size effects on high-efficiency proton conduction in three stable 3D Al-based MOFs modified with imidazole
Authors: Zhang Lu , Ma Xiaoxue , Li Xin , Liu Ronghua , Zhao Xin , Hao Hongguo , Yan Hui , Zhu Hongjie , Zhou Huawei , Zhong Dichang
Published: October 2023

Three stable porous aluminum-based MOFs 1–3 with different pore sizes were selected as an imidazole (Im) supporter and three proton conductive composites Im@1–3 were prepared. Due to the pore size effect, the σ value of Im@3 can be up to 2.55 × 10−1 S cm−1 at 80 °C and 100% RH.
Progress in organic photovoltaics for indoor application
Authors: Biswas Swarup , Lee Yongju , Choi Hyojeong , Lee Hyeong Won , Kim Hyeok
Published: October 2023

Numerous potential uses for indoor organic photovoltaic cells.
Nature inspired synthesis of magnetite nanoparticle aggregates from natural berthierine
Authors: Luis Manuel Alva-Valdivia , Amar Agarwal , Jaime Urrutia-Fucugauchi , Arnaldo Hernández-Cardona
Published: October 2023

We investigate the origin of the magnetite nanoparticle aggregates (MNAs) from the Peña Colorada iron-ore mining district (Mexico) to devise a nature inspired synthesis process.
Direct synthesis of Fe-aluminosilicates from red mud for catalytic deoxygenation of waste cooking oil
Authors: Ramdhani Eka Putra , Santoso Eko , Holilah Holilah , Nugraha Reva Edra , Bahruji Hasliza , Suprapto Suprapto , Jalil Aishah Abdul , Asikin-Mijan Nurul , Akhlus Syafsir , Prasetyoko Didik
Published: October 2023

Conversion of red mud (RM) that contains a high level of silica, alumina and iron minerals into heterogenous catalysts, offers a route for the utilization of abundant toxic by-products of bauxite refining.
The effect of MnCO3 on the gain coefficient for the 4I13/2 → 4I15/2 transition of Er3+ ions and near-infrared emission bandwidth flatness of Er3+/Tm3+/Yb3+ co-doped barium zinc silicate glasses
Authors: Dan Ho Kim , Trung Nguyen Dinh , Tam Nguyen Minh , Ha L. T. , Le Thai Nguyen , Thanh Tran Dang , Zhou Dacheng , Qiu Jianbei
Published: October 2023

NIR emission spectra of SZB-0.5Er1Tm2YbxMn (x = 0, 2, 2.5, 3, 3.5, and 4 mol%) glass samples.
Performance optimization of a thermoelectric generator for automotive application using an improved whale optimization algorithm
Authors: Quan Rui , Guo Haifeng , Liu Dazhi , Chang Yufang , Wan Hang
Published: October 2023

A TEG system using a low-backpressure polyhedral heat exchanger is optimized with an improved whale optimization algorithm (IWOA), which balances the output performance and backpressure and provides a new vision to heat exchanger optimization.
Effect of confinement and topology: 2-TIPS vs. MIPS
Authors: Venkatareddy Nayana , Mandal Jaydeep , Maiti Prabal K.
Published: October 2023

Study of 2-TIPS (two temperature induced phase separation) under different geometric confinements.
Preparation of acid-driven magnetically imprinted micromotors and selective loading of phycocyanin
Authors: Yang Guangdong , Liu Jiajing , Zhang Zhong , Yuan Li , Tian Hongye , Yang Xingbin
Published: October 2023

Acid-driven magnetic imprinting micromotors for selective recognition and loading of phycocyanin, presenting observable acid-driven motion trajectories in acidic solutions and visualized phycocyanin loading.
Intrinsically stretchable porous liquid–metal conductor for multifunctional electronics applications
Authors: Sun Xin , Yin Minghui , Xu Ruixue , Fu Zhiwei , Zhu He , Guo Qikai , Li Yang , Li Chao , Li Yan , Qian Kai
Published: October 2023

The stretchable multifunctional EGaIn conductor demonstrates promising applications in terms of nanogeneration, EMI shielding, and electrical heating.
Implementing a simplified power controller with a direct matrix converter for a PMSG‐based WECS
Authors: Gutiérrez‐Torres Diego Armando , Ramírez Juan M. , Lozano‐García José M.
Published: October 2023

This paper proposes the utilisation of the direct matrix converter (DMC) to regulate the power transfer between a permanent magnet synchronous generator (PMSG) based wind energy conversion system (WECS) and the power grid. By connecting the PMSG at the output terminals of the DMC, control actions are simplified, implementation is facilitated since fewer sensors are required, and a WECS with a more compact structure is achieved because it is not necessary to use a transformer to compensate for the DMC voltage ratio. The DMC operation is controlled by the singular value decomposition (SVD) modulation technique and the four‐step switching strategy. For power regulation, an maximum power point tracking (MPPT) algorithm based on the wind turbine power curves technique is used in conjunction with the field‐oriented control technique and a proportional‐integral compensator. In the developed prototype of the WECS described, modulation, MPPT, four‐step current switching, control algorithms, and signal measurements are implemented on a single microcontroller unit. Finally, experimental results demonstrate the effectiveness of the proposed WECS in regulating the transfer of active and reactive power adequately and simultaneously with the power grid.
Probing the face-on disc-corona system of the bare AGN Mrk 110 from UV to hard X-rays: A moderate changing-state AGN?
Authors: Porquet D. , Hagen S. , Grosso N. , Lobban A. , Reeves J. N. , Braito V. , Done C.
Published: October 2023

Context. The X-ray broadband spectra of the bare active galactic nucleus (AGN) Mrk 110, obtained by simultaneous XMM-Newton and NuSTAR observations performed in November 2019 and April 2020, are characterised by the presence of a prominent and absorption-free smooth soft X-ray excess, moderately broad O VII and Fe Kα emission lines, and a lack of a strong Compton hump. The disc-corona system is almost viewed face-on as inferred from the O VII accretion disc lines. While relativistic reflection as the sole emission is ruled out, a simplified combination of soft and hard Comptonisation (using COMPTT) from a warm and a hot corona, plus mild relativistic disc reflection (occuring at a few 10 s Rg) reproduces the data very well.

Aims. We aim to confirm the physical origin of the soft X-ray excess of Mrk 110 and to determine its disc-corona system properties from its energetics using two new sophisticated models: REXCOR and RELAGN, respectively.

Methods. We applied these models to the 0.3–79 keV X-ray broadband spectra and to the spectral energy distribution (SED) from UV to hard X-rays, respectively.

Results. At both epochs, the inferred high values of the warm-corona heating from the X-ray broadband spectral analysis using REXCOR confirm that the soft X-ray excess of Mrk 110 mainly originates from a warm corona rather than relativistic reflection. The intrinsic best-fit SED determined at both epochs using RELAGN show a high X-ray contribution relative to the UV and are very well reproduced by a warm and hot corona plus mild relativistic reflection. The outer radii of the hot and warm corona are located at a few 10 s and ∼100 Rg, respectively. Moreover, combining the inferred low Eddington ratio (approximatively a few percent) from this work, and previous multi-wavelength spectral and timing studies suggest that Mrk 110 could be classified as a moderate changing-state AGN.

Conclusions. Our analysis confirms the existence of a warm corona as a significant contribution to the soft X-ray excess and UV emission in Mrk 110, adding to growing evidence that AGN accretion deviates from standard disc theory. This strengthens the importance of long-term multi-wavelength monitoring on both single targets and large AGN surveys to reveal the real nature of the disc-corona system in AGNs.
The onset of stellar multiplicity in massive star formation: A search for low-mass companions of massive young stellar objects withL′-band adaptive optics imaging
Authors: Bordier E. , de Wit W.-J. , Frost A. J. , Sana H. , Pauwels T. , Koumpia E.
Published: October 2023

Context.Given the high incidence of binaries among mature field massive stars, it is clear that multiplicity is an inevitable outcome of high-mass star formation. Understanding how massive multiples form requires the study of the birth environments of massive stars, covering the innermost to outermost regions.

Aims.We aim to detect and characterise low-mass companions around massive young stellar objects (MYSOs) during and shortly after their formation phase. By the same means, we also probed the 3.8-μm emission that surrounds these massive protostars, in order to link the multiplicity to their star-forming environment.

Methods.To investigate large spatial scales, we carried out anL′-band high-contrast direct imaging survey seeking low-mass companions (down toLbol ≈ 10 L⊙or late A-type) around thirteen previously identified MYSOs using the VLT/NACO instrument. From those images, we looked for the presence of companions on a wide orbit, covering scales from 300 to 56 000 au. Detection limits were determined for all targets and we tested the gravitational binding to the central object based on chance projection probabilities.

Results.We have discovered a total of thirty-nine potential companions around eight MYSOs, the large majority of which have never been reported to date. We derived a multiplicity frequency (MF) of 62 ± 13% and a companion fraction (CF) of 3.0 ± 0.5. The derived stellar multiplicity and companion occurrence are compared to other studies for similar separation ranges. The comparisons are effective for a fixed evolutionary stage spanning a wide range of masses and vice versa. We find an increased MF and CF compared to the previous studies targeting MYSOs, and our results match the multiplicity rates derived among more evolved populations of massive stars. For similar separation ranges, we however confirm a higher multiplicity than that of T Tauri stars (∼30%), showing that the statement in which multiplicity scales with primary mass also extends to younger evolutionary stages. The separations at which the companions are found and their location with relation to the primary star allow us to discuss the implications for the massive star formation theories.

Conclusions.Our findings do not straightforwardly lift the uncertainty as to the formation process of massive stars as a whole but we rather examine the likely pathways for individual objects. However, the wide distance at which companions are detected rather supports core fragmentation or capture as the main mechanisms to produce wide multiples. We find hints of triggered star formation for one object and discuss the massive star against stellar cluster formation for other crowded fields.
Initiierung und endokrine Kontrolle der Geburt bei Haussäugetieren – Teil 2
Authors: Schuler Gerhard
Published: October 2023

Der endokrinen Kontrolle der Geburt liegt ein intensiver Signalaustausch zwischen Fetus, Plazenta und Mutter zugrunde. Abgesehen vom Schaf ist unser Wissen über die dabei zugrunde liegenden Prozesse immer noch sehr lückenhaft. Bisherige Beobachtungen lassen jedoch erhebliche Speziesunterschiede erkennen. Von entscheidender Bedeutung für den Eintritt der finalen, zur Austreibungsphase führenden Schritte der Signalkaskade ist der „präpartale Progesteronentzug“, der in Anhängigkeit von der relevanten Gestagenquelle in der Spätgravidität auf einer Luteolyse (z. B. Rind, Ziege, Büffel, Kameliden, Schwein) oder einem Zusammenbruch der plazentaren Gestagenproduktion (Schaf, Pferd) beruht. Das Wissen über die geburtsassoziierten Regelvorgänge ermöglicht es, für eine medikamentöse Geburtseinleitung speziesspezifische Regelmechanismen zu imitieren. Darüber hinaus stehen speziesunabhängige Wirkprinzipien wie die Blockade von Progesteronrezeptoren zur Verfügung. Neben der Wirksamkeit müssen unter Praxisbedingungen bei der Auswahl von Wirkstoffen weitere Aspekte wie die Verträglichkeit für Muttertier und Nachkommen sowie arzneimittelrechtliche Vorschriften berücksichtigt werden.
Does Lymphovenous Anastomosis Effect Mammalian Target of Rapamycin Inhibitor-associated Lymphedema Patients?
Authors: Yoon Inah , Kim Hyung Bae , Cho Jeongmok , Pak Changsik John , Suh Hyunsuk Peter , Jeon Jae Yong , Hong Joon Pio
Published: October 2023

The mammalian target of rapamycin (mTOR) inhibitors are used to prevent organ transplant rejection and are preferred over other immunosuppressants due to its low nephrotoxicity. However, mTOR inhibitors have been associated with various adverse effects including lymphedema. Although rare in incidence, previously known treatments for mTOR inhibitor-induced lymphedema were limited to discontinuation of related drugs and complex disruptive therapy with variable results.

In this article, three patients who developed lymphedema in their lower limbs after using mTOR inhibitors, including two bilateral and one unilateral case, were treated with physiologic surgery methods such as lymphovenous anastomosis (LVA) and lymph node transfer. The efficacy of the treatment was evaluated.

In the three cases described, cessation of the drug did not lead to any reduction in edema. The use of LVA and lymph node transfer resulted in early reductions in volume but failed to sustain over time. All patients underwent secondary nonphysiologic surgery such as liposuction resulting in sustained improvement.

This series presents the first physiologic approach to mTOR inhibitor-induced lymphedema. Although further study is warranted, the physiologic surgical options may have limited success and nonphysiologic options may offer better sustainable results.
Análise comparativa entre as abordagens cirúrgicas por via posterior isolada e por via anteroposterior para tratamento de escoliose severa
Authors: Verde Saulo Rabelo Lima , Lima-Verde Emílio Crisóstomo , Dias Junior Cláudio Paula Pessoa , Teixeira Gisele Façanha Diógenes , Prado Filho Cláudio Sousa , De Andrade Caio Lúcio Alencar
Published: October 2023

Objetivo Analisar comparativamente as abordagens cirúrgicas por via posterior isolada e dupla abordagem para tratamento da escoliose severa.

Métodos Analisou-se retrospectivamente prontuários de 32 pacientes com escoliose de valor angular > 70° submetidos a tratamento cirúrgico em hospital terciário entre 2009 e 2019. Dividiu-se estes pacientes em dois grupos: Grupo VP com 17 pacientes submetidos a artrodese por via posterior isolada (VP) e Grupo VAP com 15 pacientes abordados por via anterior e posterior (VAP). O Grupo VP apresentou 16 pacientes do sexo feminino e 1 do masculino, com idade média de 16,86 anos. No grupo VAP, 10 pacientes do sexo feminino e 5 do masculino, com idade média de 17,71 anos. Os ângulos de Cobb foram mensurados por único cirurgião de coluna, manualmente, em radiografias panorâmicas, em ortostase no pré- e pós-operatório. Foram avaliados também peso, altura pré- e pós-operatória e duração do procedimento.

Resultados No Grupo VP, o ângulo de Cobb pré-operatório e pós-operatório, verificados na curva principal, foram respectivamente 96,06° ± 8,45° e 52,27 ± 15,18°, apresentando taxa média de correção de 0,54 ± 0,16. No grupo VAP, esses valores foram de 83,12° ± 11,60° para o ângulo de Cobb pré-operatório, 48,53 ± 10,76, pós-operatório, com a taxa de correção da curva principal de 0,58 ± 0,11.

Conclusão As duas formas de abordagem cirúrgica para tratamento de escoliose severa se equiparam quanto à taxa de correção da deformidade. Portanto, o acesso posterior isolado apresenta vantagem em relação a dupla via, baseado no menor tempo cirúrgico, menor tempo de internação e menos risco de complicações
Geographical Origin, WASH Access, and Clinical Descriptions for Patients Admitted to a Cholera Treatment Center in Northwest Syria between October and December 2022
Authors: Hmaideh Ahmad , Tarnas Maia C. , Zakaria Wasim , Rifai Ahmad Oussama , Ibrahem Mosab , Hashoom Yaser , Ghazal Nusaima , Abbara Aula
Published: October 2023

Background On September 10, 2022, a cholera outbreak was declared in Syria for the first time in over a decade of protracted conflict. As of May 20, 2023, 132,782 suspected cases had been reported, primarily in northwest and northeast Syria. We aim to provide a detailed description of water sources and clinical status of a patient cohort seen at a cholera treatment center (CTC) in northwest Syria.

Methods We retrospectively identified patients with confirmed cholera who presented to the CTC in Idlib governorate between October 8 and December 18, 2022. Data were obtained from clinical case records and analyzed in R v4.0.4.

Results Ninety-four patients (55.3% men) were treated at the CTC. Thirty-five patients were severely dehydrated (Plan C treatment), 54 had some dehydration (Plan B), and 5 had no dehydration (Plan A). Most patients were between 11 and 20 years old (n = 25, 26.6%) or 31 and 40 years old (n = 19, 20.2%). Note that 70.2% (n = 66) of patients were seen in November 2022 and most were from Harim district (n = 44, 46.8%). Public wells (n = 46, 48.9%) and water trucking (n = 41, 43.6%) were the most commonly used water sources. Note that 76.6% (n = 72) did not have access to chlorine-treated water. Forty-seven patients (50%) had more than five water, sanitation, and hygiene (WASH)-related cholera risk factors. Following treatment, six patients were transferred to another treatment center, three died (case fatality rate: 3.2%), and the remainder were discharged.

Conclusion Most patients reported WASH-related risk factors for cholera, reflecting the poor state of WASH in northwest Syria after over a decade of conflict. This relates to the direct and indirect impacts of urban and periurban violence as well as the underfunded humanitarian response. Strengthening WASH and health promotion are important components to control the outbreak.
Fatores de risco para formação de lesão cyclops sintomática após a reconstrução do ligamento cruzado anterior
Authors: Helito Camilo Partezani , Silva Andre Giardino Moreira da , Giglio Pedro Nogueira , Pádua Vitor Barion Castro de , Pécora José Ricardo , Gobbi Riccardo Gomes
Published: October 2023

Objetivo Avaliar a incidência de lesões cyclops sintomáticas que precisam de tratamento cirúrgico após a reconstrução do ligamento cruzado anterior (LCA) e estabelecer os possíveis fatores de risco intraoperatórios relacionados a elas.

Métodos Trezentos e oitenta e nove pacientes com idades entre 18 e 50 anos submetidos à reconstrução primária do LCA foram avaliados de forma retrospectiva. Os pacientes foram divididos em grupos de acordo com a presença ou ausência de lesões cyclops sintomáticas e suas características foram comparadas. Não foram incluídos pacientes com lesões associadas que necessitassem de outros procedimentos cirúrgicos (à exceção de procedimentos extra-articulares ântero-laterais). A taxa de lesões cyclops sintomáticas foi registrada e os seguintes parâmetros foram avaliados: idade, sexo, tempo da lesão à cirurgia, tipo e diâmetro do enxerto, técnica de perfuração do túnel femoral, tipo de fixação, presença de hiperextensão do joelho, preservação do LCA remanescente, associação a procedimento extra-articular ântero-lateral, lesão de menisco associada e participação em esportes.

Resultados Dos 389 pacientes avaliados, 26 (6,7%) desenvolveram lesão cyclops. Os pacientes com e sem lesão cyclops não diferiram quanto à idade, tempo da lesão à cirurgia, tipo ou diâmetro do enxerto, técnica cirúrgica, método de fixação femoral, presença de hiperextensão do joelho, preservação do LCA remanescente e lesão de menisco associada. O grupo com lesão cyclops apresentou mais mulheres (10 [38,4%] vs. 68 [18,7%]; razão de probabilidades [OR] = 2,7; p = 0,015), maior proporção de reconstrução extra-articular (18 [11,8%] vs. 8 [3,4 %]; OR = 3,8; p = 0,001) e maior proporção de prática esportiva (23 [8,6%] vs. 3 [2,5%]; OR = 3,6; p = 0,026).

Conclusão Em nossa série, 6,7% dos pacientes necessitaram de remoção artroscópica das lesões cyclops. O sexo feminino, a reconstrução extra-articular associada e a prática esportiva foram fatores relacionados a essa lesão. A preservação do menisco remanescente não foi associada à formação de lesões cyclops.
Delayed Posttraumatic Blepharocele: A Rare Case Report with Review of the Literature
Authors: Patankar Amey P. , Chaudhary Shivani
Published: October 2023

Though posttraumatic cerebrospinal fluid (CSF) rhinorrhea and otorrhea are fairly common, blepharocele and blepharoencephalocele are rare, with only 15 cases reported to date.

A 29-year-old female patient presented with a complaint of swelling of the right eyelid that had begun three months before. The patient had sustained a head injury 24 years prior to presentation.

Imaging studies revealed the presence of a craniopalpebral CSF fistula. The patient underwent successful surgical repair of the fistula with craniotomy and duroplasty by autologous fascia lata graft.

Delayed development of blepharocele 24 years after trauma is unusual, and, to our knowledge, the case herein reported is the first one in the literature.
Evaluation and obstacle analysis of high-quality development in Yellow River Basin and Yangtze River Economic Belt, China
Authors: Yang Xiaolin , Feng Zengwei , Chen Yiyan
Published: October 2023

Based on China’s new development philosophy, and following the idea of “assessing the overall levels firstly, then anchoring the subsystems contributions and finally identifying the obstacle factors”, an evaluation system of high-quality development (HQD) levels is constructed from five subsystems of innovative development (ID), coordinated development (CD), green development (GD), open development (OD) and shared development (SD). In this paper, the entropy weight TOPSIS model is used to measure the HQD levels of 19 provincial units located in the Yellow River Basin (YRB) and the Yangtze River Economic Belt (YREB) in 2010–2019, and with the assistance of the Obstacle Degree Model, the obstacle factors affecting the HQD of both are depicted. The results show that: (1) between 2010 and 2019, the HQD indices in YRB and YREB have been on an increasing trend, and the subsystems indices all show a trend of “GD > CD > SD > ID > OD”, but the overall levels of HQD in both is not high, and there is still much room for improvement. (2) YREB has a significantly higher HQD level than YRB. From 2010 to 2019, the average values of the HQD indices in YRB and YREB were 0.2886 and 0.4073, respectively, but the index in YRB improves at a faster pace than YREB, and the gap of HQD levels between the two show a trend of continuous reduction towards regional balance and coordination. (3) The analysis of obstacle factors shows that while OD and ID are the main obstacles to HQD in both basins, the impact of both on the resistance to HQD in both basins is on a decreasing trend. GD is another bottleneck for the HQD of YRB, and the pressure on GD in the middle and upper reaches of the provincial units in the basin is increasing, and the obstacles are on a rising trend.
Confidence in organic food: a cross-country choice based conjoint analysis of credibility factors
Authors: Nagy László Bendegúz , Unger-Plasek Brigitta , Lakner Zoltán , Temesi Ágoston
Published: October 2023

The primary objective of this research is to examine the diverse product attributes related to the credibility of organic food. Given that organic quality of food products is considered a credence attribute, establishing credibility plays a pivotal role in consumers’ decision-making processes when purchasing organic products. The lack of credibility represents a significant barrier to the growth of the organic market. Therefore, it is crucial to explore the specific product attributes that can enhance the perceived credibility of organic products. To assess the various factors influencing credibility, a choice-based conjoint method was employed. The study involved Hungarian participants (n = 652) and Polish participants (n = 290), who were asked to select a hypothetical product they deemed more credible. The findings reveal that the country of origin, appearance, and packaging exert the most substantial influence on the perceived credibility of organic food. Additionally, price and the place of purchase were identified as factors that also impact consumer perceptions.
First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant
Authors: Bernaldo-de-Quirós Esther , Camino Manuela , Martínez-Bonet Marta , Gil-Jaurena Juan Miguel , Gil Nuria , Hernández-Flórez Diana , Fernández-Santos Maria Eugenia , Butragueño Laura , Dijke I. Esmé , Levings Megan K. , West Lori J. , Pion Marjorie , Correa-Rocha Rafael
Published: October 2023

Due to their suppressive capacity, regulatory T cells (Tregs) have attracted growing interest as an adoptive cellular therapy for the prevention of allograft rejection, but limited Treg recovery and lower quality of adult-derived Tregs could represent an obstacle to success. To address this challenge, we developed a new approach that provides large quantities of Tregs with high purity and excellent features, sourced from thymic tissue routinely removed during pediatric cardiac surgeries (thyTregs). We report on a 2-year follow-up of the first patient treated worldwide with thyTregs, included in a phase I/II clinical trial evaluating the administration of autologous thyTreg in infants undergoing heart transplantation. In addition to observing no adverse effects that could be attributed to thyTreg administration, we report that the Treg frequency in the periphery was preserved during the 2-year follow-up period. These initial results are consistent with the trial objective, which is to confirm safety of the autologous thyTreg administration and its capacity to restore the Treg pool.