bluuebunny/crossref_metadata_2025 huggingface dataset:
Pertimbangan pemasangan implan gigi pada pasien lanjut usia
Authors: Grecila Susilo Sonya , Ariesanti Yessy
Published: December 2023

Background: The elderly population is a group of people who are vulnerable have tooth loss so it is common to use of dental implant for replace it. Unfortunately, decreased function and changes in the condition of the tissues of the oral cavity and alveolar bones due to the aging process are often make installation of implant more complicated. Futhermore, in the elderly often found systemic diseases such as hypertension, diabetes mellitus, osteoporosis or cardiovascular diseases that affect the installation of implants. But if the quality and quantity of alveolar bone and soft tissue are adequate accompanied by a healthy elderly condition, it is possible that implant placement will be succesfull.

Case Report: A 69-years-old male patient attended a clinic to replace his missing right lower teeth with permanent denture. After undergoing several examinations, it was decided to perform dental implant on tooth 46, diameter 3.8 mm and length 10.5 mm with a cemented-screw type PFM crown. The implant and PFM crown were successfully placed in tooth 46 and patients were comfortable with the implant without any complaints of pain.

Conclusion: chronological age by itself is suggested as one of the risk factors for success, but it would not be a contraindication as long as the condition of the alveolar bone is adequate and systemic disease is well controlled.
Faktor-faktor yang Mempengaruhi PenurunanTulang Marginal Pada Awal Pemasangan Implan Dental
Authors: Rinda  , Ariesanti Yessy
Published: December 2023

Background: A dental implant is a prosthetic or alloplastic material, which is embedded in the bone, to maintain retention and support for fixed or removable dental prosthetics. One of the challenging obstacles in dental implant treatment is marginal bone resorption. Early marginal bone loss (MBL) is a non-infective remodelling process of variable entity occurring within the first year after implant placement. It has a multifactorial etiology, being influenced by both surgical and prosthetic factors. Marginal bone loss is an important indicator to determine long term success of implant treatment. Radiographic evaluation are very renowned way to assess the longitudinal bone attachment to the implant.

Case report : A 32 -year-old female patient came to RSGM USAKTI with a chief complaint of missing lower right posterior teeth 15 years ago due to big caries. Patient wanted to replace with implant. Comprehensive evaluation, like CBCT was done to make sure that she was indicated for dental implant. Insertion of BTK implant was done on the first phase of surgery. Implant was left for 3 months for osseointegration. Radiographic evaluation of the second phase of surgery there was a bone resorption about 2- 4 mm, but no mobililty, no signs of inflammation and no pain. In this case, Initial bone resorption diagnosis is essential because it gives the clinician a guideline for the necessity of corrective and preventive treatments.

Conclusion: maintenance of gingival health around implant is important for decreasing bone loss.
Kepuasan pasien di jakarta barat terhadap gtsl nilon termoplastik
Authors: Wirahadikusumah Andy , Funny Setioningrum Dominica
Published: December 2023

disorders, and aesthetic function. Partial tooth loss can be overcome by using removable partial dentures (RPD). There are various types of removable partial dentures, one of which is made of thermoplastic nylon. Objectives: To describe patient satisfaction using thermoplastic nylon-based removable partial dentures in West Jakarta. Materials and Methods: a descriptive observational study using a cross-sectional method. 109 Respondent participated in this study. A Validated quesionnaire containing 20 questions was given via Google forms to measure patient satisfaction. Results: 20 questions that have passed the validity and reliability tests, the results show that the age group that uses the most nylon thermoplastic RPD is 36-45 years (42.2%). There were more female respondents than female respondents (67.49%). Most of the denture use time is less than 1 year (56%). The highest distribution of tooth loss was a combination of anterior and posterior teeth (42.2%), front of the maxilla (23.9%), back of the mandible (21.1%), back of the maxilla (11.9) and the least was the front of the mandible (0.9%) ). As many as (1.8%) were dissatisfied, 12.8% were satisfied, and 85.3% were very satisfied with their thermoplastic nylon removable partial denture. Conclusion: 93 respondents were very satisfied with their thermoplastic nylon removable partial dentures.
Kestabilan implan gigi 46 dengan diameter 3,3 mm
Authors: Magdalena Yuniati Maria , Tjandrawinata Rosalina
Published: December 2023

Background: Losing teeth can cause problems such as the emergence of mastication, aesthetics, and phonetics. One of the solutions to restore these functions is dental implant. This method is in demand because apart from being able to restore function, the implant will also protect the jawbone from the process of resorption due to tooth loss. This is possible because dental implants are surgically implanted into the jawbone, then dentures can be placed over them to adapt the oral condition

Case report: A 63-year-old woman with controlled hypertension came with complain of extracted lower right tooth 1 year ago and she wanted a fixed prosthesis to replace this tooth. She had not good experience with removeable denture at upper jaw. the jawbone has undergone resorption due to tooth loss which was not immediately rehabilitated. A single unit Straumann BLT dental implant of diameter 3.3 mm x height 10 mm is placed on this patient after treatment planning with radiograph image and study model analysis. Screw-cemented retained prosthesis was delivered on the implant to restore the function and aesthetic of the missing 46 tooth.

Conclusion: Good planning and proper procedure during implant placement and restoration will lead to an excellent long-term aesthetic and functional outcome.
Guided Bone Regeneration to Support Lack of Mandibular Buccal Plate
Authors: Chairio Wiwi , Pudjowibowo Hartono
Published: December 2023

Background: Insufficient bone condition can pose a significant challenge in dental implant procedures. The success of implant therapy relies on having sufficient bone thickness at the implant site. Factors such as bone atrophy, periodontal disease, trauma, and intermaxillary relationships (vertical, horizontal, and sagittal) can lead to insufficient bone volume for placing implants. To address this issue, bone augmentation techniques are commonly used to restore function and improve aesthetics in areas with inadequate bone. Various techniques and materials are available for bone augmentation, including Guided Bone Regeneration (GBR), which is one of the known methods with varying success rates. Objective:  provide information about the management of bone augmentation in dental implants using the GBR technique. Case report:  involves a 21-year-old male patient who sought treatment at a clinic to resolve functional issues and prevent dental shifting following a tooth extraction. The patient desired permanent dentures for the left mandibular area. After undergoing several examinations, it was determined that dental implants on tooth 46, with a diameter of 4.1 mm and length of 10 mm, accompanied by a cemented-screw type porcelain-fused-to-metal (PFM) crown, would be appropriate. In this particular case, the GBR technique with allograft bone grafts was employed for bone augmentation. After approximately one year of observation, evidence of new bone formation was observed, indicating the success of the dental implant treatment. Conclusion: there are several effective techniques for correcting inadequate bone conditions before placing dental implants.
Komunikasi oro-antral paska pencabutan sisa akar gigi 16
Authors: Dipankara Jackson , Lulu Afifah Himawan Dinda , Poedjiastoeti Wiwiek
Published: December 2023

The opening of the sinus cavity due to tooth extraction, infection, or some complications so that an abnormal pathway is formed is oroantral communication. If the abnormal pathway fails to close, it turns into an oro-antral fistula. In this case report, patients performed tooth 16 and 17 extractions, but oroantral communication only occurred in the socket after tooth extraction 16.  The diagnosis of oroantral communication is established based on the patient's complaints when gargling after tooth extraction, patients complain of water coming out of the nasal cavity and smell of blood. Then it was confirmed by clinical examination by instructing the patient to close the nose and then blow air while examining the retraction socket area, the results of the examination showed air passing through the blood in the retraction socket. The management of this case is done by giving a gelatin sponge into the socket and suturing with the figure of eight techniques or with non-surgical treatment. The results of the treatment showed the closure of oroantral communication.
Kualitas hidup terkait kesehatan gigi dan mulut pada anak prasekolah di Batam
Authors: Nabillah Rulifa Syarah , Asia Asyurati
Published: December 2023

Background: The high number of dental and oral health problems in preschool children, such as dental caries, can indirectly interfere with children's development and daily activities. This situation will affect children's Oral-Health Related Quality of Life (OHRQoL) up to his family. Objective: Defines the quality of life related to dental and oral health at Nabilah Kindergarten in Batam City District. Methods: This research is a descriptive observational study with a cross-sectional design to describe the Oral-Health Related Quality of Life at Nabilah Kindergarten in Batam City District. The research was conducted by distributing ECOHIS questionnaire sheets consisting of 13 question items to 79 mothers of Nabilah Kindergarten students in Batam City District. Respondents filled out the informed consent and ECOHIS questionnaire sheets. The assessment of Oral-Health Related Quality of Life in the questionnaire is divided into four categories, namely good, sufficient, bad, and very bad. The score of each respondent's answer is added up and then adjusted based on the score range of the ECOHIS questionnaire. Results: The results showed that Oral-Health Related Quality of Life in the children impact section was in the good category 68.4%, sufficient 29.1%, bad 2.5%. Meanwhile, the family impact section was 58.2% good, 35.4% sufficient, and 6.3% bad. Conclusion: Oral-Health Related Quality of Life at Nabilah Kindergarten in Batam City District tends to be in the good category.
Pelepasan monomer resin komposit nanofil dan mikrohibrid dengan penyinaran berbeda
Authors: Ratnasari Dina , Elsa Prahasti Anastasia , Elline
Published: December 2023

Background: Many factors affect the elution of composite resin monomers, such as filler size and light-curing unit used. Objectives: to compare the effect of the filler size and light-curing unit on the elution of monomers. Methods: Subjects were 20 composite resins, consists of 10 microhybrid composite resins and 10 nanofilled composite resins, diameter 4.5 mm and height 2 mm. Composite specimens were cured using halogen light-curing unit 680 mW/cm² or LED 1000 mW/cm², for 20 seconds according to group random allocation. Specimens were put into 1 mL artificial saliva, soaked for 24 hours and then were analyzed with LC-MS/MS, for TEGDMA elution. Results: Two-ways ANOVA test showed there were differences in the influence of filler size and light-curing units type on monomer elution (p < 0.05). The mean of monomer TEGDMA eluted from micro-hal 2.4960 µg/mL ± 0.49318 µg/mL, micro-LED 0.03114 µg/mL ± 2.0820 µg/mL, nano-hal 1.8120 µg/mL ± 0.24273 µg/mL, and nano-LED 1.5000 µg/mL ± 0.0255 µg/mL. Tukey test showed microhybrid composite resin eluted more TEGDMA than nanofilled composite resin (p < 0.05). There were no significant differences in the elution of TEGDMA monomers with the use of light-curing unit halogen or LED (p > 0.05). Conclusion: Different filler size influenced the elution of composite resin monomer. The polymerization of the nanofilled composite resin is better than microhybrid composite resin, proved by less nanofilled composite resin monomer eluted. The use of halogen light-curing unit or LED light-curing unit, showed no difference in the effect on the elution of monomer.
Perilaku pembersihan gigi tiruan lengkap pada Lansia panti werdha hana
Authors: Falatehan Niko , Andreas Rama
Published: December 2023

Background: Behavior in cleaning full denture in the elderly has an important role in the success of complete denture treatment. This behaviour is an important thing so that patients can maintain the cleanliness of full denture and the health of their oral cavity. This study aims to determine the full denture cleaning behavior in the elderly. Methods: This type of research was descriptive observational with a cross-sectional design conducted on 32 elderly people in Hana Nursing Home, Pamulang, South Tangerang. The behavior of the elderly is measured through a questionnaire that has been provided previously. Results:The results of the descriptive statistical test showed that in general the behavior of cleaning of the elderly at the Hana Nursing Home had good results (46.9%). This good behavior is obtained based on good knowledge (59.4%), fairly good attitude (56.3%), and fairly good actions (53.1%). Based on gender grouping, it was obtained by the elderly group of men having full denture cleaning behavior which entered into a fairly good category (50%). Whereas the elderly woman in the Hannah Nursing Home has cleaning behavior that is included in the good category (50%). Based on age grouping, it can be seen that full denture cleaning behavior is good for the eldery age group (60-74 years), whereas in the old age group (75-90 years) and very old age group (> 90 years) has a cleaning behavior is in fairly good category. Conclusion:The behavior of cleaning the full denture influenced by the knowledge, attitudes and actions taken by the elderly full denture users.
É POSSÍVEL VIVENCIAR A GINÁSTICA ACROBÁTICA NA ESCOLA? POSSIBILIDADE DE INTERVENÇÃO NA EDUCAÇÃO BÁSICA
Authors: Dantas Noronha Cisne Mabel , Rocha Fernandes Maria Petrília , Patrícia Lima Barros Elainny Patrícia Lima Barros , Maria Braga da Silva Isabelle , De Castro Marques Ribeiro Manoela , Renato Bezerra Filho Sérgio , Simões Ferreira Heraldo Simões Ferreira , Paiva Marcelo
Published: December 2023

Este estudo relata uma experiência pedagógica desenvolvida nas aulas de Educação Física de uma escola municipal de Fortaleza, entre os meses de maio e junho de 2022. A atividade proposta refere-se à experimentação e fruição, de forma individual e coletiva dos elementos básicos da Ginástica Acrobática. Para tal, partimos de questões geradoras para avaliar os conhecimentos prévios sobre a modalidade, seu histórico, regras e principais fundamentos, por meio dessa aproximação inicial sistematizamos as intervenções dos encontros subsequentes. Portanto, tem-se como objetivo: relatar a experiência de escolares com a implementação e efetivação de uma modalidade esportiva pouco frequente nas aulas de Educação Física escolar, a Ginástica Acrobática. No procedimento metodológico, utilizou-se a pesquisa exploratória do tipo bibliográfica no intuito de fundamentar a discussão teórica. Em nosso último encontro acerca da Ginástica Acrobática, foi aplicado um questionário aos escolares. Através da análise das respostas obtidas por meio da aplicação de um questionário, constatou-se que a introdução da modalidade de ginástica acrobática resultou na ampliação do repertório motor dos alunos, estimulando também a motivação em relação às aulas de Educação Física. Além disso, observou-se uma receptividade positiva em relação a novas práticas proporcionadas por essa modalidade, contribuindo para o aperfeiçoamento do entendimento dos alunos sobre a temática abordada.
Dissolution of synthetic diamonds to produce morphologies similar to natural diamonds: an experimental study
Authors: Zhimulev E.I. , Gryaznov I.A. , Chepurov A.A. , Sonin V.M. , Chepurov A.I.
Published: December 2023

The results on dissolution of flat-faced synthetic diamond crystals of octahedral habit in an Fe-Ni-S melt at 4.0 GPa and 1 400°C are presented. It has been established that the resulting diamond morphology is similar to some natural kimberlitic diamonds and follows the particular sequence: flat-faced octahedron – laminar octahedron – trisoctahedroid with parallel striations in the <110> direction (“O1-D1”). Comparing the obtained results with earlier experimental works it is concluded that oxidisation of octahedral diamonds by means of ditrigonal etching layers and formation of tetrahexahedroid form is a result of diamond interaction with the fluidised kimberlite magma. We suggest that formation of octahedral diamonds with trigonal etching layers does not occur in kimberlite magma, and that diamonds of the O1-D1 morphological series avoided natural oxidation in kimberlite magma, but, like flat-faced octahedrons, were enclosed within xenoliths. Most probably, this dissolution process took place in the mantle prior to their capture by kimberlite. The results support an idea that metal-sulphide melts could be considered not only as a growth place for the world’s largest Cullinan-like diamonds found in South Africa (CLIPPIR type), but also as a mantle agent producing crystal morphologies typical for common kimberlitic diamonds: it depends upon carbon content in metal-sulphide melt – with supersaturation of the melt, the growth of diamond occurs while at the undersaturation conditions the dissolution begins.
RESEPSI PEMBACA PRIA TERHADAP KARYA SASTRA “MARIPOSA” DI KOMUNITAS CYBERSASTRA WATTPAD
Authors: Iwan Adi
Published: December 2023

ABSTRAK: Karya sastra dapat diakui keberadaanya salah satunya dengan adanya seberapa banyak respon pembaca dari berbagai kalangan. Penelitian ini bertujuan untuk mengungkap resepsi pembaca pria terhadap sebuah karya cyber yang berjudul “ mariposa” pada situs wattpad. Wattpad adalah penyedia jasa publikasi cerita yang bisa dinikmati pembaca online di seluruh dunia. Agak penelitian tercapai peneliti mengumpulkan 40 orang dengan latar belakang pendidikan SMA, S1, S2 dan guru dengan rentan usia 17 – 30 tahun. Metode penelitian ini menggunakan metode kualitatif dengan penyebaran kusioner secara daring.teknik analisi data menggunakan teknik isi Hasil dari penelitian ini menunjukan respon yang berbeda walaupun pembaca membaca genre yang sama. Respon yang ditujukan pembaca lebih mengarah kepada  unsur tekstual yaitu tokoh, alur dan bahasa. Dengan latar pendidikan SMA, S1, S2 dan guru berpendapat bahwa unsur tekstual dalam karya sastra dengan respon yang positif.
KATA KUNCI: cybersastra, resepsi, mariposa
> 
MAN READER'S RECEPTION OF LITERATURE "MARIPOSA" IN WATTPAD CYBERSASTRA COMMUNITY
 
ABSTRACT: One of the ways in which literary works can be recognized is the number of responses from readers from various circles. This study aims to reveal the reception of male readers to a cyber work entitled "mariposa" on the wattpad site. Wattpad is a story publication service provider that can be enjoyed by online readers around the world. Rather than the research being achieved, the researcher collected 40 people with a high school, undergraduate, postgraduate and vulnerable teacher education background aged 17-30 years. This research method uses qualitative methods with online questionnaires. Data analysis techniques use content techniques. The results of this study show different responses even though the reader reads the same genre. The response aimed at the reader is more towards textual elements, namely characters, plot and language.
KEYWORDS: cybersastra, reception, mariposa
Study on structural design and hydrodynamic response law of new floating wind power fishery integration
Authors: Zhu Jiangfeng , Cao Yuguang , Liu Yuanyuan , Ren Chenyi , Zhao Qiankun
Published: December 2023

The new lattice floating wind turbine integrated system (also known as Dot Matrix Floating wind turbine, and hereinafter referred to as DMF) is proposed as a new concept. It is a design scheme that combines multiple wind turbines into a polygonal floating foundation in the form of a lattice arrangement, which can meet the research and development requirements of higher power generation equipment in the future. More far-reaching, it has obvious advantages over the traditional floating wind turbine scheme in terms of structural cost and motion stability, which provides a new idea for the development of offshore wind power energy. Firstly, the structural parameters and mechanical model of DMF are analyzed to determine the feasibility and superiority of the overall scheme of the new lattice foundation. Combined with the traditional OC4 semi-submersible wind turbine system, the hydrodynamic simulation under wind, wave, and current load is carried out, and the hydrodynamic response law of DMF under the different environmental factors is summarized and analyzed. It is concluded that the stability of DMF in pitching motion is 70% higher than that of traditional OC4 system. In order to further verify the feasibility of the DMF system and the accuracy of the theoretical model, based on the similarity theory, this study carried out the small-scale prototype processing of DMF and the simulation experiment of wind wave flume. The test results are in good agreement with the simulation data. Finally, aiming at the problem of the large amplitude of swaying motion response of DMF in the simulation results, a mooring optimization scheme suitable for the new DMF is proposed, which provides 47% stability compared with the traditional catenary mooring through comparative analysis. This study provides a reference and theoretical basis for the research and development of offshore multi-wind turbine combined equipment and hydrodynamic stability optimization. It has certain theoretical guiding significance and economic development value.
Improving the efficiency of solar-driven trigeneration systems using nanofluid coolants
Authors: Alshuraiaan Bader
Published: December 2023

This article is intended to evaluate methods to improve the efficiency of trigeneration plants, which are designed for the co-generation of heat, electricity, and cold. The possibility of using nanofluids with the addition of oxides of aluminum, silicon, magnesium, and copper, as well as copper itself in the concentration range of 1–6% has been analyzed. The results show that the use of nanofluids can increase the exergic efficiency of the system to 22.9–27.8% and increase thermal efficiency by 23.2–26.7%. It was found that nanofluids have low heat capacity, which may be one of the factors that increase the overall efficiency of trigeneration plants up to 43–60%. Magnesium oxide proved to be the most efficient for generating electricity, with 212.8 kW, aluminum oxide (197.5 kW) for cooling, and copper oxide for generating 98 kW of heat. The Pearson criterion was χ2 = 0.87, Student’s t-test 0.07–0.09, statistical significance of results p ≤ 0.005.
Abordagem geral da pneumonia associada à ventilação mecânica
Authors: Martins Fernanda Jorge , Vieira André , Freitas Camila Melo de , Sottomaior Carla Larissa Cunha , Melo Neto Fernando de Paiva , Martins Gabriele Rânia Garcia , Souza Giovanna Alves de , Alves Suzana Cássia Feltrin , Assis Victor Barbosa , Reis Renandro de Carvalho
Published: December 2023

Objetivo: Descrever a abordagem geral ao paciente com pneumonia associada à ventilação mecânica (PAV). Revisão bibliográfica: A narrativa buscou na literatura demonstrar e esclarecer os diferentes aspectos e principais características da PAV em seis subcategorias: a fisiopatologia, quadro clínico, fatores de risco, diagnóstico e conduta terapêutica, bem como as medidas preventivas. Constitui uma doença que provoca uma inflamação do parênquima pulmonar após 48 horas do início da utilização do sistema de ventilação mecânica invasiva, e sua etiologia está associada com a aspiração de substâncias contaminadas advindas da orofaringe. O quadro clínico envolve aumento da respiração e/ou frequência cardíaca e febre ou parâmetros respiratórios alterados, como aumento de secreções purulentas ou piora da hipoxemia, e seu tratamento depende da escolha de antibióticos agressivos, administrados em dosagem correta, observando-se a função renal e a duração da ventilação mecânica. A PAV é um tema de alta relevância, em especial devido ao seu impacto econômico na rede de saúde, no tempo de permanência hospitalar dos indivíduos e na mortalidade associada. Considerações finais: É de extrema importância o conhecimento dos mecanismos envolvidos na PAV e das suas manifestações clínicas, a fim de garantir um rápido diagnóstico e um adequado e eficiente tratamento.
Análise do tumor ocular mais comum na infância: retinoblastoma
Authors: Rosa Jéssica do Valle , Siqueira Emílio Conceição de
Published: December 2023

Objetivo: Analisar as características do retinoblastoma (RB). Revisão bibliográfica: ORB é o tumor intraocular maligno mais comum em crianças, causado por mutações no gene do retinoblastoma (RB1) situado no cromossomo 13q14.2. O RB afeta cerca de 1 em 16.000 nascidos vivos.A herança autossômica dominante é observada em 30 a 40% dos casos, enquanto o tipo esporádico não herdado é responsável pelos 60 a 70% restantes, sendo a idade média de diagnóstico de 1 ano para os casos hereditários e de 2 anos para o esporádico. Os principais sintomas são leucocoria e estrabismo. Considerações finais: O RB é altamente curável quando diagnosticado precomente. Dessa forma, seu manejo perpassa por sua rápida identificação e tratamento adequado. O diagnóstico é clinico com o exame de fundo de olho, sendo a biopsia contra indicada. A terapêutica depende do grau de acometimento ocular ou sistêmico, podendo ser usadas crioterapia e fotocoagulação a laser para tumores de baixo risco ou quimioterapia intra-arterial, quimioterapia sistêmica e enucleação para casos mais avançados e mestastásicos.
Likely increase in coral thermal tolerance at a Pacific archipelago
Authors: Lachs Liam
Published: December 2023

Over the coming decades, reef-building corals will face ever hotter ocean temperatures, yet it remains unknown if their thermal tolerance can keep up with the pace of warming. A new study reveals that coral thermal tolerance in Palau has likely risen by 0.1 °C/decade since the late 1980s. Despite this ecological resilience, strong action on climate change remains a priority to protect coral reefs.
Take Them Outside: Cold Air Helps Croup Symptoms in Kids
Authors: Valbret Zoé
Published: December 2023

Although for many years parents and paediatricians have noticed that cold fresh air helps improve children’s croup symptoms, there was no scientific data to support this. Now, a team in Geneva carried out a randomized clinical study that supports this claim; it shows that going outside in cold fresh air helps initially reduce the severity of croup symptoms in children.
Pityriasis Rubra Pilaris: An Uncommon Presentation
Authors: Méndez-Flores Silvia , Santoyo Marla Lucero Vega , Saeb-Lima Marcela
Published: December 2023

Human immunodeficiency virus (HIV) associated pityriasis rubra pilaris (PRP) or PRP Type VI is a distinctive entity reported in HIV patients. We report a patient with skin Type V (based on the Fitzpatrick scale), and HIV infection, presenting with an atypical clinical manifestation (non-acneiform), and with an uncommon distribution of this entity but characteristic histological findings of Type VI PRP. We review the clinical features, pathology and possible aetiology of this entity.
Interhemispheric asymmetrical change in gray matter volume in patients with unilateral hippocampal sclerosis
Authors: Mugikura Shunji , Mori Naoko , Gang Miyeong , Kanno Shigenori , Jin Kazutaka , Osawa Shin-Ichiro , Nakasato Nobukazu , Takase Kei
Published: December 2023

Objectives:

To clarify the interhemispheric asymmetrical change in gray matter volume (GMV) in unilateral hippocampal sclerosis (HS), we compared changes in GMV relative to normal subjects between the HS and contralateral or non-HS sides.

Material and Methods:

Forty-five patients with unilateral HS and 30 healthy subjects were enrolled. We quantified changes in GMV in the patients with HS as compared to GMV in the normal subjects by introducing the Z-score (Z-GMV) in each region or region of interest in unilateral HS. Then, we assessed the asymmetrically decreased regions, that is, regions with significantly higher Z-GMV on the HS side than the contralateral or non-HS side. Z-GMV was calculated according to the two templates of 58 regions per hemisphere covering the whole brain by anatomical automatic labeling (AAL) and 78 regions per cerebral hemisphere using the Anatomy Toolbox.

Results:

Seven and four regions in AAL and 17 and 11 regions in Anatomy Toolbox were asymmetrically decreased in the Left Hand Side (LHS) and Right Hand Side (RHS), respectively. Hippocampus and Caudate in AAL, five subregions of the hippocampus (CA1–3, Dentate Gyrus and hippocampus-amygdala-transition-area and 4 extrahippocampal regions including two subregions in amygdala (CM: Centromedial, SF: Superficial), basal forebrain (BF) (Ch4), and thalamus (temporal) in anatomy toolbox were common among LHS and RHS concerning asymmetrically decreased regions.

Conclusion:

By introducing Z-GMV, we demonstrated the regions with asymmetrically decreased GMV in LHS and RHS, and found that the hippocampus and extrahippocampal regions, including the BF, were the common asymmetrically decreased regions among LHS and RHS.
Thinking outside the guttural box: fresh perspectives on vowel lowering in Qeltu
Authors: YASEEN Abdulkareem
Published: December 2023

This study revisits the process of vowel lowering in the Arabic dialect known as Qeltu, which is spoken in parts of northern Iraq and neighboring Syria and Turkey. It aims to uncover hitherto unreported patterns of vowel lowering and re-examines a frequently held axiom that attributes a categorical impact of specific linguistic units on the behavior of this phonological process (e.g. Al-Ani, 1970; Thelwall, 1990; Rose, 1996). The analysis of spoken data from 30 speakers considers various linguistic and social constraints that may or may not influence the process of vowel lowering. The data was collected through sociolinguistic interviews (Tagliamonte, 2006). It is generally acknowledged that the main allophones of Iraqi Arabic [i], [iː], [uː] (Al-Khalesi, 2006) are respectively realized as [a], [ɛː], and [ɔː] in Qeltu (Jastrow, 1994 & 2006). This is especially noticeable when these vowels are adjacent to guttural sounds, as exemplified in the words: /miʃhuːr/ famous, /sˤtˤuːħ/ roof and /daqiːq/ flour, which are pronounced as [maʃhɔːr], [sˤtˤɔ:ħ] and [daqɛ:q], respectively (Jastrow, 1994; Muhammad, 2018). Results indicate that the relationship between guttural sounds and the lowering of vowels in Qeltu cannot be solely predicted by their proximity to each other, and that additional social factors are involved in determining this phenomenon.
Education and the Narrative Aspect of Temporality
Authors: Bühlmann Quero Jakob
Published: December 2023

Byung-Chul Han (Seoul, 1959) establishes one of the most meaningful and deep understandings of the experience of the contemporary subject. In his view, temporality has suffered a radical atomization that translates into a fragmented life experience: a collection of isolated instants devoid of a sense of duration. As a by-product of this circumstance, we see our very way of thinking and learning changing accordingly. Where we used to find knowledge, we now see information. The aim of this paper will be to explore the transformative power of education in the context of our “broken” temporality.
Temporal Horizons in Education
Authors: Honen-Delmar Mélodie
Published: December 2023

This paper extracts the findings of the impact study on the Learning Facilitator programme’s study, a 6-month blended learning professional programme accredited by the Catholic University of Eichstätt-Ingolstadt (Germany) and delivered by Jesuit Worldwide Learning to teachers in context of marginalisation. Focused on elucidating how the Learning Facilitator programme nurtures graduates' soft skills in teaching and fosters their servant-leadership, this paper underscores how the programme redefines the temporal horizons for its participants, enabling them to transcend established frames of reference and cultivate inclusive and conducive learning environments both within and beyond the confines of traditional classrooms. This contribution seeks to bring the seldom heard voices at the centre of the discussion on “time for education”, echoing graduates’ critical exploration in reevaluating conventional frames of reference in pedagogical contexts.
CIME4R: Exploring iterative, AI-guided chemical reaction optimization campaigns in their parameter space
Authors: Humer Christina , Nicholls Rachel , Heberle Henry , Heckmann Moritz , Pühringer Michael , Wolf Thomas , Lübbesmeyer Maximilian , Heinrich Julian , Hillenbrand Julius , Volpin Giulio , Streit Marc
Published: December 2023

Chemical reaction optimization (RO) is an iterative process that results in large and high-dimensional datasets. Current tools only allow for limited analysis and understanding of parameter spaces, making it hard for scientists to review or follow changes throughout the process. With the recent emergence of using artificial intelligence (AI) models to aid RO, another level of complexity was added. It is critical to assess the quality of a model’s prediction and understand its decision to aid human-AI collaboration and trust calibration. To that regard, we propose CIME4R—an open-source interactive web application for analyzing RO data and AI predictions. CIME4R supports users in (i) comprehending a reaction parameter space, (ii) investigating how the RO process developed over iterations, (iii) identifying critical factors of a reaction, and (iv) understanding model predictions. This aids users in making informed decisions during the RO process and helps them review an RO process in retrospect, especially in the realm of AI-guided RO. CIME4R aids decision-making through the interaction between humans and AI by combining the strengths of expert experience and high computational precision. We developed and tested CIME4R together with domain experts and verified its usefulness with three case studies. With CIME4R the experts were able to produce valuable insights from past RO campaigns and make informed decisions on which experiments to perform next. We believe that CIME4R is the beginning of an open-source community project that improves the workflow of scientists working in the reaction optimization domain.
Spaces of mathematical chemistry
Authors: Restrepo Guillermo
Published: December 2023

In an effort to expand the domain of mathematical chemistry and inspire research beyond the realms of graph theory and quantum chemistry, I explore five mathematical chemistry spaces and their interconnectedness through mappings. These spaces are characterised by their elements and the concept of proximity that binds these elements within the space. These spaces comprise the chemical space, which encompasses substances and reactions; the space of reaction conditions, spanning the physical and chemical aspects involved in chemical reactions; the space of reaction grammars, which encapsulates the rules for creating and breaking chemical bonds; the space of substance properties, covering all documented measurements regarding substances; and the space of substance representations, composed of the various ontologies for characterising substances.
Deformation of Nanoporous Carbons Induced By Multicomponent Adsorption: Insight from the SAFT-DFT Model
Authors: Corrente Nicholas J. , Hinks Elizabeth L. , Kasera Aastha , Neimark Alexander V.
Published: December 2023

Deformation of nanoporous materials during gas adsorption has been attracting considerable attention due to various applications including energy and gas storage separations, carbon capture, and separations. While most of practical applications involve multicomponent mixtures, most of experimental and theoretical works deal with single component adsorption. Here, we study the specifics of adsorption-induced deformation during displacement of methane by carbon dioxide from carbon nanopores, the process of a paramount importance for secondary gas recover and carbon sequestration in shale and coal formations. Density functional theory calculations augmented by the perturbed chain statistical associating fluid theory (SAFT-DFT) and grand canonical Monte Carlo (GCMC simulations are employed to model adsorption of CH4-CO2 mixtures on carbon slit pores of various size. We found a non-monotonic behavior of the adsorption deformation with increasing pressure and varying mixture composition that is explained by the peculiarities of molecule packings confined to nanoscale pores. The SAFT-DFT method is shown to produce results which are in agreement with atomistic GCMC simulations at a fraction of the computational cost. The SAFT-DFT method can be extended to study adsorption selectivity and deformation effects for complex mixtures, including hydrocarbons and CO2.
Convenient one-pot synthesis and biological evaluation of novel 3,5-dimethyl-1H-pyrazole-1-carbothiohydrazide derivatives as new anti-tumor agents against both liver carcinoma (HepG2) and lung carcinoma (A549) cell lines
Authors: Fouad Marwa , Elaasser Mahmoud
Published: December 2023

Pyrazle constituents have garnered consideration mainly because of their presumed biological and curative properties. Therefore, the goal of the presented research is to create some novel pyrazole-1-carbothiohydrazide derivatives with predicted biological functions using an accessible one-pot synthesis employing 3,5-dimethyl-1H-pyrazole-1-carbothiohydrazide (1) as a facile antecedent. The component 1 and 1,3-diphenylpropane-1,3-dione (2) interacted resulting in pyrazole derivative 3 when ethanol or acetic acid were supplied. However, when the substance 1 interacted in ethanol with either 2 or acetyl acetone 5, using the catalytic proportion of triethylamine offered, it yielded compounds 4 and 6 respectively. Ingredient 1 was subjected to additional reactions with ethyl cyanoacetate (7), stearic acid 10, or equivalent carboxylic acids 12a-c, resulted in the formation of 9, 11, and 13a-c consequently. Additionally, when 1 was combined with α-haloketones 14 or 16, it yielded the corresponding 1,3,4-thiadiazine derivatives, 15 and 17. Every designed product's chemical structure was established according to spectroscopic and analytical results. The cytotoxic activities of the synthesized chemicals were assessed against two carcinoma cell lines, and compared to the standard drug Cisplatin using the colorimetric MTT assay. Furthermore, the results revealed that chemical 17 was the most active against the liver and lung carcinoma cell lines giving potent IC50 value of 5.35 and 8.74 μM, respectively, compared with reference drug cisplatin (3.78 and 6.39 μM). Interestingly, ingredient 17 when evaluated for their toxicity against normal lung fibroblast (MRC-5) cells exhibited low toxic effects indicating the safe use. Generally, our results exerted promising bioactive compounds.
Single-Point Grand Potential and Nuclear Derivatives of Finite-Temperature Kohn-Sham Density-Functional Theory
Authors: ZHANG Yichi , Chan Ka Lok , Sheong Fu Kit
Published: December 2023

We present an implementation of single-point grand potential, nuclear gradient and nuclear hessian for finite-temperature Kohn-Sham density-functional theory (FT-DFT) in the grand canonical ensemble. It is shown that evaluation of single-point grand potential and nuclear gradient of FT-DFT is much similar to that of single-point energy and nuclear gradient of zero-temperature DFT, with no need for nested-loop optimization or approximation. The nuclear hessian is divided into two parts, the fixed-occupation-number component and the variable-occupation-number one, as a result of fractional occupation of molecular orbitals. We have developed two techniques, namely the non-idempotent CPSCF and the occupation-gradient CPSCF for those two components, respectively. The convergence of single-point grand potential is discussed, while the analytical nuclear derivatives are verified via comparison with numerical results.
Biomimicry of Limpet Teeth with Hybrid Colloidal Liquid Crystals: Mechanical Enhancement by Structural Orderliness from Self-Assembly
Authors: zhao hongbo , Pei Renjun , Wang Pei-Xi
Published: December 2023

The teeth of limpets, consisting of orderly aligned hard goethite (iron oxyhydroxides) nanocrystals and flexible chitin microfibers, are one of the hardest and stiffest biomaterials found in nature. However, the replication of their composition and ordered microstructures to artificial biomimetic materials remains a challenge. Here, we fabricated large-sized limpet tooth analogues with hierarchically ordered structures by applying long-range orientational control to the short-scale self-assembly of hybrid colloidal liquid crystals formed by chitin nanocrystals and goethite nanorods. The obtained lightweight composite laminates exhibited excellent bending resistance compared with biomaterials, cements, and ceramics. These results suggest that the mass production of structurally ordered materials with high strength and toughness may be achieved using lyotropic liquid crystals.
Diffuse basis functions for explicitly correlated calculations on the heavy p-block: aug-cc-pVnZ-PP-F12 sets for Ga–Kr, In–Xe, and Tl–Rn
Authors: Hill Grant
Published: December 2023

New aug-cc-pVnZ-PP-F12 basis sets (n = D, T, Q) for the heavy p-block elements, Ga–Kr, In–Xe, and Tl–Rn, have been developed by augmenting the cc-pVnZ-PP-F12 sets with additional higher angular momentum diffuse functions. These basis sets have been optimized for use in explicitly correlated F12 calculations, and matching auxiliary basis sets for density fitting of conventional and F12 integrals have also been developed. The new sets have been validated with benchmark CCSD(T)-F12b calculations of electron affinities, where an accelerated convergence to the complete basis set limit is evident. The effect of the additional diffuse functions on electron affinities is shown to be comparable to the effect of correlating the outer-core d electrons.
Identification of hydrocarbon sulfonates as previously overlooked transthyretin ligands in the environment
Authors: Gong Yufeng , Sun Jianxian , Barrett Holly , Peng Hui
Published: December 2023

Incidences of thyroid disease, which has long been hypothesized to be partially caused by exposure to thyroid hormone disrupting chemicals (TDCs), have rapidly increased in recent years. However, only ~1% of the binding activity of human transthyretin (hTTR), an important thyroid hormone transporter protein, can be explained by known TDCs. In this study, we aimed to identify the major hTTR ligands in Canadian indoor dust and sewage sludge by employing protein-guided nontargeted analysis. hTTR binding activities were detected in all 11 indoor dust and 9 out of 10 sewage sludge samples (median 458 and 1134 μg T4/g in dust and sludge, respectively) by the FITC-T4 displacement assay. Through employing protein Affinity Purification with Nontargeted Analysis (APNA), 31 putative hTTR ligands were detected including perfluorooctane sulfonate (PFOS). Two of the most abundant ligands were identified as hydrocarbon surfactants (e.g., dodecyl benzenesulfonate), which were confirmed by authentic chemical standards. Structure-activity relationships (SAR) of hydrocarbon surfactants were explored by investigating the binding activity of 11 hydrocarbon surfactants to hTTR. Optimal carbon chain length (C12-14) was found to achieve a high binding affinity. By employing de novo nontargeted analysis, another abundant ligand was surprisingly identified as a di-sulfonate fluorescent brightener, 4,4'-Bis(2-sulfostyryl)biphenyl sodium (CBS). CBS was validated as a nM-affinity hTTR ligand with an IC50 of 345 nM. In total, hydrocarbon surfactants and fluorescent brightener could explain 1.92-17.0% and 5.74-54.3% of hTTR binding activities in dust and sludge samples, respectively, whereas PFOS only contributed <0.0001% to the activity. Our study revealed for the first time that hydrocarbon sulfonates are previously overlooked hTTR ligands in the environment.
Advancing Force Fields Parameterization: A Directed Graph Attention Networks Approach
Authors: Chen Gong , Jaffrelot Inizan Théo , Plé Thomas , Lagardère Louis , Piquemal Jean-Philip , Maday Yvon
Published: December 2023

Force Fields (FFs) are an established tool for simulating large and complex molecular systems. However, parametrizing FFs is a challenging and time-consuming task that relies on empirical heuristics, experimental data, and computational data. Recent efforts aim to automate the assignment of FF parameters using pre-existing databases and on-the-fly ab-initio data. In this study, we propose a Graph-Based Force Fields (GB-FFs) model to directly derive parameters for the Generalized Amber Force Field (GAFF) from chemical environments and research into the influence of functional forms. Our end-to-end parameterization approach eliminates the need for expert-defined procedures and enhances the accuracy and transferability of GAFF across a broader range of molecular complexes. The GB-FFs model, which is only grounded on ab initio data, is implemented in the highly parallel Tinker-HP GPU package. Simulation results are compared to the original GAFF parameterization and validated on various experimentally and computationally derived properties, including free energies.
The effect of etiopathogenetic therapy of COVID-19 on the severity of the disease: results of a multicenter double-blind placebo-controlled randomized trial
Authors: Nikiforov Vladimir V. , Petrov Vladimir A. , Stremoukhov. Anatoly A. , Avdeeva Marina G. , Shvarts Yury G. , Kravchenko Irina E. , Nikolaeva Irina V. , Ushakova Svetlana E. , Belousova Oksana N. , Eremina Natal'ia A. , Teplykh Svetlana V. , Mel'nikova Ekaterina V. , Kostinа Natal'ia E.
Published: December 2023

Aim. The search for etiopathogenetic agents to prevent the development of severe and extremely severe COVID-19 remains relevant. A placebo-controlled randomized clinical trial was conducted to evaluate the efficacy and safety of the antibody-based biological drug (Raphamin).Materials and methods. 785 outpatients 18–75 y.o. with laboratory confirmed mild COVID-19 were included within 24 hours from the disease onset. 771 patients were randomized to the group Raphamin (n=382) and the Placebo group (n=389). The study drug/placebo was prescribed for 5 days. The rate of progression to a more severe degree of COVID-19 by day 28 as well as the time to sustained clinical recovery and the frequency of hospitalization were evaluated. Safety was assessed taking into account adverse events, vital signs and laboratory parameters.Results. The number of cases of progression to a more severe degree of COVID-19 in participants receiving Raphamin was 59 (15.5%) [52 (14.6%)] versus placebo – 89 (22.9%) [85 (23.7%)], ITT and [PP] analysis data are presented. The odds ratio between groups was OR=0.6157 [OR=0.5494], 95% confidence interval 0.4276–0.8866 [0.3750–0.8048], which meant a reduction in the chance of progression to a more severe degree by 38.4% [45.1%] or 1.48 [1.62] times; p=0.0088 [p=0.0019]. The time to sustained recovery in the Raphamin group was 4.5±2.4 [4.6±2.4] days, versus placebo – 5.8±4.7 [6.0±4.8] days; p=0.0025 [p=0.0036]. No adverse events with a certain relationship were registered.Conclusion. Raphamin reduces the risk of progression to a more severe degree of the COVID-19 and significantly shortens the duration of clinical symptoms.