bluuebunny/crossref_metadata_2025 huggingface dataset:
Importancia de la vacunación dentro del manejo integrado de Rhipicephalus microplus en bovinos
Authors: Jaramillo Hernández Dumar Alexander
Published: November 2022

El complejo Rhipicephalus microplus es el más prevalente y mejor adaptado tanto en zonas tropicales como subtropicales, siendo el más importante ectoparásito dentro de los sistemas de producción bovina del mundo. Es imperante anudar esfuerzos técnico-científicos para generar planes de manejo integrado de este parásito, reduciendo de forma estratégica el uso de acaricidas convencionales para su control, evitando así las formas multi-resistentes y alteraciones evidentes de inocuidad en productos y subproductos de origen bovino, además de los impactos deletéreos ambientales. La vacunación como herramienta de control relevante en los planes de manejo integrados para R. microplus está disponible comercialmente en Colombia, como en otros países del continente americano. Gavac™ en Cuba, Bovimune Ixovac® en México y Go-Tick® en Colombia son biológicos tangibles y ampliamente validados para controlar el flagelo de R. microplus y los brotes de enfermedades trasmitidas por este parásito, como también para reducir significativamente la dependencia de acaricidas convencionales en sistemas de producción de bovinos. Los resultados de la estructuración estratégica en contexto del manejo integrado de R. microplus detallan ganancias económicas importantes y consciencia ecológica.
Peningkatan Peran Masyarakat Sebagai Pengelola Objek Wisata di Desa Ameth Kabupaten Maluku Tengah
Authors: Latupapua Yosevita Theodora , Kastanya Agustinus , Latuamury B , Mardiatmoko G
Published: November 2022

Desa ameth merupakan salah satu desa dari 7 desa di Negeri Nusa laut kabupaten Maluku Tengah, yang dikenal sebagai desa pesisir dengan potensi daya tarik alam bahari dan pesisirnya yang mampu menarik minat kunjungan pengunjung dalam melakukan aktifitas wisata di negeri tersebut. Namun pengunjung objek yang datang di negeri Ameth belum memberikan nilai yang signifikan bagi masyarakat lokal.  Metode yang digunakan dalam kegiatan pengabdian ini adalah metode ceramah, indepth interview dan kuisioner. Kegiatan dilakukan selama 10 hari. Peserta kegiatan terdiri dari masyarakat selaku pengelola objek yang dalam hal ini adalah kepala soa, dan saniri negeri sebanyak 15 orang.  Pelaksanaan kegiatan diawali dengan adanya pre test, penyuluhan, observasi kawasan objek, setelah itu post test. Kegiatan ini mendapat sambutan yang sangat baik dari peserta, dan terjadi perubahan tingkat pemahaman masyarakat yang terukur melalui hasil pre test dan post test sebesar 100%.
Optimal decisions and channel coordination of a green supply chain with marketing effort and fairness concerns
Authors: Huang Fuyou , Xiong Dan , Ma Chao
Published: November 2022

This paper addresses the optimal decisions and channel coordination issues in a green supply chain composed of a socially responsible manufacturer and a fair-mined retailer, where the manufacturer invests in advanced facilities/technologies to improve green quality of products, and the retailer exerts marketing effort to enhance market demand. We develop supply chain models under three scenarios: centralized system, wholesale price (WP) contract without fairness concerns, and WP contract with fairness concerns. Our results show that the retailer’s fairness behavior further causes a benefit for herself, while the manufacturer and the total supply chain to suffer. Moreover, a revenue-cost-sharing (RCS) contract is introduced to coordinate supply chain . We prove that a win-win outcome is reachable, and the RCS contract is applicable in practice.
Towards sustainable development exemplified by monitoring land use efficiency in Europe using SDG 11.3.1
Authors: Bielecka Elżbieta , Calka Beata
Published: November 2022

Monitoring land use efficiency (LUE) is of great importance for the sustainable development of each country. The identification of regions where land consumption prevails over demographic growth should prompt public administrations to act and establish a recovery programme. This paper took Europe as the research area, and CORINE Land Cover and statistical population data to assess changes and spatial diversity of the LUE status from 2006 to 2018. Results show that, during the 2006–2012 period, LUE was more diversified than in 2012–2018. The differences concern both values of the indicator and the spatial differentiation between regions. Between 2012 and 2018, the number of countries moving towards efficient land use doubled compared to 2006–2012. Great progress towards achieving SDG 11.3.1 was seen in Portugal and Germany, and almost all Balkan countries are moving towards more efficient land use.
Implications of the FMEA Method in Evaluating Amirkabir Dam’s Environmental Risk
Authors: Kassem Yousef , Gökçekuş Hüseyin , Iravanian Anoosheh , Nategh Mehrdad
Published: November 2022

There are various environmental risks in both the construction and operation phases of huge civil projects such as dam construction. As a result, it is critical to implement appropriate risk control and risk mitigation measures before the initiation of the activities posed by these schemes. The goal of this research is to identify and categorize the environmental risks posed by the Amirkabir Dam during its construction and operation phases. After identifying the risks, the risk factors were prioritized using the FMEA method, with the risks being ranked according to their severity, probability of occurrence, and ability to detect. The study’s findings revealed that the highest risk in the dam construction stage is associated with road construction and vehicle exhaust gases (RPNs of 280 and 252, respectively), and the highest risk in the operation phase is associated with borrow area overuse (erosion and sediment downstream of the dam) (RPN of 280).
ANALISIS KEBUTUHAN PENGEMBANGAN BUKU PERKULIAHAN GENETIKA BERBASIS KAJIAN MISKONSEPSI PADA PROGRAM STUDI PENDIDIKAN BIOLOGI
Authors: Sukmawati Ika , Permadani Karunia Galih
Published: November 2022

Mata kuliah genetika mengandung topik yang dianggap sulit dan banyak ditemukan miskonsepsi. Oleh sebab itu, dikembangkanlah buku perkuliahan enetika berbasis kajian miskonsepsi. Penelitian ini merupakan penelitian deskriptif eksploratif sebagai bagian dari tahap Analyze dalam model ADDIE, dengan subyek mahasiswa Program Studi Pendidikan Biologi Universitas Tidar yang menempuh mata kuliah genetika. Sampel dipilih secara acak sejumlah 45 mahasiswa yang terdiri dari 42 perempuan dan 3 laki-laki. Berdasarkan hasil penelitian diketahui bahwa: (1) mahasiswa masih belum memahami ruang lingkup kajian genetika secara utuh; (2) genetika dianggap sebagai materi yang sulit dipahami; (3) Buku teks yang sudah ada masih sulit untuk dipelajari dan dipahami; (4) Mahasiswa menyadari bahwa karakteristik materi dan sumber belajar pada mata kuliah genetika rawan memicu miskonsepsi; (5) Mahasiswa membutuhkan buku perkuliahan dengan memperhatikan area/materi yang rawan memicu miskonsepsi. Berdasarkan hasil penelitian, disimpulkan bahwa buku perkuliahan genetika berbasis kajian miskonsepsi perlu dikembangkan guna memfasilitasi pembelajaran mahasiswa yang lebih berkualitas.
A review on the ecotoxicological effects of heavy metals on aquatic organisms-siftdesk
Authors:   Shandong Agricultural University, Wang Jiting
Published: November 2022

In recent years, with the rapid development of the global economy, heavy metals have been widely used in industrial production and daily life because of their unique properties. This, however, has simultaneously led to heavy metal pollution due to various reasons. After entering the aquatic environment, heavy metals are not easily decomposed by microorganisms and become toxic when they reach a certain concentration. Heavy metals can easily enter the liver and other vital organs of aquatic organisms, where they accumulate and severely affect the growth and reproduction of these organisms. They can also threaten human health through the food chain. Therefore, heavy metal pollution has potential ecological and health risks. This paper summarizes the sources and hazards of heavy metals in water, the pattern of enrichment of heavy metals in aquatic organisms, the toxic effects of heavy metals on aquatic organisms, the tolerance mechanism of aquatic animals to heavy metals, and the factors affecting the toxicity of heavy metals. The authors put forward three feasible suggestions for the study of ecotoxicological effects of heavy metals on aquatic organisms in the future. The results of this study have considerable significance for aquaculture and environmental management and even for humans.
Comparative Analysis of Volatile Flavor Compounds of Different Pot-stewed Lotus Rhizomes by SPME-GC-MS and E-nose
Authors: Yan Shoulei , Liu Yanzhao , Li Li , Li Jie
Published: November 2022

Electronic nose and gas chromatography-mass spectrometry (GC-MS) were used to analyze the volatile flavor compounds of pot-stewed lotus rhizomes made in the laboratory (PSLR) and other three samples sold in the market. Principal component analysis (PCA) of the electronic nose and GC-MS data suggested that lotus rhizome stewed in laboratory has unique flavor. There were 65 kinds of volatile flavor components in PSLR (sample A), 51 kinds in sample B, 49 kinds in sample C and 41 kinds in sample D. There were 25 kinds of common components in four pot-stewed lotus rhizomes, such as β - myrcene, d-limonene, β - ocimene, α - terpinene, γ – terpinene, linalool, (-) - 4-terpineol, α - terpineol, anethol and eugenol. The principal component analysis (PCA) can find out the characteristic components which determine the flavor of different pot-stewed lotus rhizome products, and the overall flavor of PSLR samples is better than that of market products.
Wild Daucus Carota Oil Extract: An Innocuous Preventative and Chemotherapeutic Agent Against Chemically Induced Breast Cancer-siftdesk
Authors:   Lebanese American University, F. Daher Costantine , Elias Maria George , Mrad Yves Najm , Nehmeh Bilal , Dagher Carole , Mroueh Mohamad , Taleb Robin I
Published: November 2022

Daucus carota L. ssp. carota oil extract (DCOE) was shown to possess potent antitumor activity. This study investigates the chemopreventive and chemotherapeutic effects of DCOE against breast cancer induced by 7,12-Dimethylbenz(a)anthracene (DMBA) in rats. In the chemopreventive study, animals were pre-treated with DCOE (25 mg/kg; 1 week) followed by 14 weeks of treatment post-cancer induction with DMBA. In the chemotherapeutic study, animals were allocated into control, DCOE (25 mg/kg) and Cisplatin (2.5mg/kg) groups. When tumor size reached a diameter of 14-15 mm, the animals were divided into three groups each injected by either a vehicle (thrice a week), DCOE (thrice a week) or Cisplatin (twice a week), for 8 weeks to compare and assess the therapeutic value of DCOE with respect to Cisplatin and the vehicle. At 24 weeks, the experiment was terminated. DCOE pre-treatment protected against DMBA-induced toxicity and reduced tumor incidence. While 18% of control died few days post DMBA treatment, 100% survival in DCOE pre-treated group was observed just before week 8. In the chemotherapeutic experiment, treatment with either DCOE or Cisplatin caused significant inhibition of tumor growth. Unlike DCOE, Cisplatin caused drastic decrease in body weight with 75% and 100% death rates at week 6 and 8 respectively. DCOE produced a significant increase in Bax/Bcl2 ratio, Cytochrome c and cleaved caspase 3 proteins. DCOE may be considered a safe chemopreventive and/or chemotherapeutic agent, an effect that is partly due to the induction of the intrinsic apoptotic pathway.
Intentional Alarm Calling in Wild Female Putty-Nosed Monkeys (Cercopithecus nictitans)
Authors: Mehon Frederic , Stephan Claudia
Published: November 2022

The intentionality that characterizes human language currently still lacks conclusive evidence for precursors in animal vocal communication. Complex intersubjectivity as in language is usually supposed to be either evolutionary rooted in gestural communication or unique to humans. Here we systematically tested various groups of wild putty-nosed monkeys (Cercopithecus nictitans) for female first-order intentional alarm calling using a recently suggested framework to comparatively test for intentionality in animal communication. Specifically, we used a leopard model to elicit female alarm calls that usually trigger the group’s male alarm calls and further recruit that male to mob and deter the nearby predator. We experimentally disentangled male alarm calling from male predator mobbing to test for female goal directedness in recruiting males for predator defense, voluntary alarm call usage, and the successful manipulation of male behavior. Females monitored male behavior and immediately ceased own alarm calling once the group’s male took over group defense but not after perceiving the male’s typical alarm calls. Unsuccessful male recruitments and the absence of male predator mobbing resulted in persistent and considerably longer female alarm calling. We discuss different communicative functions of female alarms and conclude that our results are most likely explained by the intentional use of female alarms in order to recruit males as ‘hired guns.’
A Field-Based Adaptation of the Classic Morris Water Maze to Assess Learning and Memory in a Free-Living Animal
Authors: McKay Leah , Hunninck Louis , Sheriff Michael
Published: November 2022

Free-living animals rely on cognitive functions, such as learning and memory, for numerous aspects of their survival. However, research involving these mechanisms is often limited to the laboratory where animals are far removed from natural influences. Here, we adapted the Morris Water Maze (MWM) for use in the field to test learning and memory of free-living white-footed mice, Peromyscus leucopus. The MWM consists of a pool filled with opaque water and a platform that is hidden beneath the surface of the water. Mice were tasked with finding an escape platform using proximate-cue based spatial learning skills across trials within and between two tests. The two tests occurred 2 hrs apart and each consisted of 5 trials with a maximum search time of 60 s, separated by 15-s breaks. We found mice demonstrated rapid learning within the first 5 trials, as indicated by a faster time and reduced distanced swam to find the platform in trial 5 as compared to trial 1 in Test 1. We also found mice remembered the task, as indicated by equivalent performance (in time and distance) after the two-hour delay period (i.e., performance in Test 2 trial 1 was similar to that in Test 1 trial 5). Lastly, we found that there was no increase in performance as mice completed an additional 5 trials (i.e., no difference in Test 1 trial 5 vs. Test 2 trial 5). By assessing several variables that serve as standard metrics for learning and memory within the MWM, we were able to illustrate the ability of wild mice to successfully navigate within a modified version of an established learning/memory paradigm. This study is important for promoting more accessible forms of cognitive testing in free-living animals and use of such a method could provide insights into how animals cope with environmental stressors in their natural environment such as anthropogenic disturbance, invasive species, and habitat degradation. A better understanding of cognitive behavior in wild animals may help diminish the disparity of knowledge that is often present between laboratory and field research.
¿Qué es la Terapia de Aceptación y Compromiso?
Authors:   University of Nevada, Nevada, Reno, US, Hayes Steven C. , Strosahl Kirk D. ,   Heart Matters Consulting, Spokane, Washington, US, Bunting Kara ,   San Francisco, California, US, Twohig Michael , Wilson Kelly G. ,   University of Mississippi, University, Mississippi, US
Published: November 2022

El ser humano utiliza el lenguaje para moldear su mundo, para estructurarlo y darle sentido. El lenguaje construye nuestros rascacielos, contribuye a la fuerza de nuestro acero, crea la elegancia de nuestras matemáticas y forma la representación de la belleza en nuestro arte. El lenguaje ha sido la fuente de tantos logros humanos que es natural que lo utilicemos de forma prioritaria para identificar un problema y elaborar una solución. Pero, precisamente porque el lenguaje puede sernos tan útil, también puede ser problemático. El lenguaje no solo permite los logros humanos, sino también nuestra capacidad para proyectar futuros terribles, para compararnos con ideales irreales y encontrar nuestras carencias, o para atormentar nuestras almas con la finitud de la vida misma. El lenguaje está en el centro de la habitual tendencia humana de sufrir en medio de la abundancia...
Un manual de ACT: Procesos fundamentales de la terapia, estrategias de intervención y competencias del terapeuta
Authors:   Heart Matters Consulting, Spokane, Washington, US, Strosahl Kirk D. , Hayes Steven C. ,   University of Nevada, Nevada, Reno, US, Wilson Kelly G. ,   University of Mississippi, University, Mississippi, US, Gifford Elizabeth V. ,   University of Nevada, Nevada, Reno, US, Virues-Ortega Javier ,   The University of Auckland, Auckland, New Zealand, Valero Aguayo Luis ,   Universidad de Málaga, Málaga, Spain, Virues-Ortega Javier ,   The University of Auckland, Auckland, New Zealand
Published: November 2022

El propósito de este capítulo es presentar una visión general consolidada de las intervenciones del tratamiento ACT y de los procesos terapéuticos. En el Capítulo 1 describimos la filosofía, la teoría básica y aplicada y los procesos teóricos que definen colectivamente ACT como un sistema clínico. En este capítulo examinaremos los pasos clínicos concretos que se utilizan en la aplicación de este modelo...
SUBSTANTIATION OF THE PHYSICO-CHEMICAL PARAMETERS OF THE SUBSTANCES RUTIN AND HESPERIDIN FOR THE CREATION OF DISPERSIBLE TABLETS
Authors: M.S. Perepelitsyn , A.M. Shevchenko , T.Y. Mandzhigoladze
Published: November 2022

According to the data provided by the World Health Organization, disorders in the functioning of the cardiovascular system lead to disappointing consequences. A third of deaths worldwide occur in this category of diseases. In this regard, the urgency of developing and creating medicines for the prevention and treatment of cardiovascular diseases, including chronic venous insufficiency, is increasing. As active substances, we selected insoluble forms of hesperidin and rutin. One of the main properties of water-insoluble substances used for the preparation of dispersible tablets is the degree of dispersion of medicinal substances. As a consequence, the aim of the work was to study the physico-chemical characteristics of rutin and hesperidin, which are necessary to ensure optimal biopharmaceutical properties of dispersed tablets. The following materials were used during the work: substances of rutin and hesperidin, a PE-5300V spectrophotometer, a laser particle size analyzer ANALYSETTE 22 NanoTec, a microscope "Micromed-1" with a trinocular nozzle and a digital camera HA2307 HDMI industrial camera (14MP). According to the results of the conducted studies, the average particle size for the substances rutin and hesperidin was established, which amounted to 17 microns and 2.6 microns, respectively. Micrographs of the studied substances of rutin and hesperidin were made using a microscope with a trinocular nozzle, and their visual examination was also carried out. In accordance with the results of microscopy, it can be noted that the substance rutin requires additional grinding in order to improve the biopharmaceutical properties of the dispersible tablets. While, the substance of hesperidin has sufficient dispersion to obtain the developed dosage form.
MITOCHONDRIAL DYSFUNCTION AS CRITERION OF DISEASE PATHOGENESIS
Authors: I.N. Chernenko , A.O. Mikhailov , N.G. Plekhova
Published: November 2022

Mitochondrial dynamics is associated with important cellular functions such as metabolism and autophagy. The balance between fusion and fission of mitochondria is an integral component of the production of ATP molecules in cells. Modern data indicate the essential importance of dynamic changes in mitochondria, both in the restoration of damage and in the progression of diseases. A detailed study of the molecular mechanisms underlying the pathogenesis of diseases is necessary to create high-quality methods for personalized diagnostics. A promising direction in this area of research is the study of metabolic disorders of mitochondria, which can affect the development and progression of pathologies of various origins. It has been shown that in cardiovascular diseases the energy intensity of myocardial muscle functioning depends on the activity of mitochondria. The review presents the latest data on the role of these cell organelles in the pathogenesis of damage in ischemia-reperfusion, cardiomyopathies, atherosclerosis, cardiac hypertrophy, and other pathologies. The dynamics of changes in mitochondria, the phases of biogenesis (fusion, division) and mitophagy associated with the mechanisms of bioenergetic adaptation of various cell types in myocardial cells and other tissues are considered. The possibility of using data on the state of mitochondria for the prevention and treatment of diseases is presented.
FEATURES OF CORONARY ARTERIES IN MEN UNDER 60 YEARS OLD WITH ACUTE URINARY RETENTION IN MYOCARDIAL INFARCTION
Authors: A.V. Gordienko , A.S. Balabanov , A.S. Izmuhanov , V.A. Reiza , V.V. Tupitcyn , B.A. Chumak
Published: November 2022

Relevance. Acute urinary retention (AUR) adversely affects the the patient’s quality of life and the prognosis of myocardial infarction (MI).
Aim. To evaluate features of the coronary arteries state in men under 60 years old with myocardial infarction complicated by AUR to improve prevention and outcomes.
Material and methods. The study included men aged 19-60 years old with MI were studied. The patients were divided into two age comparable groups: I - study group, with AUR - seven patients; II - control, without it - 132 patients. A comparative analysis of the coronary angiography indicators, AUR risk analysis (Pearson's Chi-square) were performed.
Results. The study group did not differ from the control group in the numbers of affected arteries and the extent of the lesion, its localization and depth. The study group was characterized by complete occlusion of the coronary arteries (in the study group: 100%; control: 32.7%; p = 0.003), the absence of revascularization (0 and 17.0%; respectively; p = 0.03), re-current lesions (22.7 and 3.7%; p ˂ 0.0001), as well as a large maximum stenosis (100.0 ± 0 and 92.8 ± 10.6%; p = 0.03). The same parameters were associated with the risk of AUR development.
Conclusions. Men under than 60 years old with AUR in MI are characterized by a higher incidence of complete occlusions of the coronary arteries and failure to perform revascularization. These angiographic parameters indicate that the patient belongs to the high-risk group for severe MI and the development of AUR. It is advisable to use them for the timely imple-mentation of preventive measures and for predictive modeling.
INFLUENCE OF EXTRACT RUMEX CONFERTUS ON METABOLIC PROCESSES IN THE BODY
Authors: E.O. Kulichenko , A.M. Temirbulatova , S.L. Adzhiakhmetova , L.P. Lezhneva
Published: November 2022

Vital physiological and metabolic processes occurring in the human body are associated with free radical oxidation, which affects the structure, permeability and physico-chemical properties of biological membranes. Horse sorrel is used for scurvy, gout, diabetes, jaundice, hypertension, rheumatism, skin diseases – scabies, lichen, eczema, burns, as well as diseases of the digestive and cardiovascular systems. The purpose of the research: to study the technology of obtaining liquid extract of horse sorrel roots and to study its antioxidant activity on the body. Liquid extract of horse sorrel roots and auxiliary substances were used as the object of the study: dimethyl sulfoxide DMSO, ethyl alcohol 96%, quercetin, lecithin. When performing the work, equipment was used: liquid chromatograph "Color Yauza-01-AA", SF-LEKISS 1207UV. The object of the study of the total antioxidant activity were extracts of horse sorrel roots obtained using ethyl alcohol in concentration: 30%, 40%, 50%, 60%, 70%, 80%. The total content of antioxidants in the studied liquid extracts of horse sorrel roots was determined by two methods: using a liquid chromatograph "Color Yauza-01-AA" with an amperometric detector. The quantitative content of antioxidants was determined according to the calibration schedule. The conversion was carried out for gallic acid and quercetin. Using a model of iron-induced lipid peroxidation in the system of lecithin (phosphotidylcholine) liposomes, the studied liquid extracts were evaluated by reducing the accumulation of peroxide compounds. The study was carried out at a concentration of 200 mcg/ml to 500 mcg/ml of horse sorrel extract and increasing the dose.
TO THE QUESTION OF THE QUALITY-OF-LIFE PECULIARITIES IN MEN UNDER 60 YEARS OLD WITH URINATION DISTURBANCES IN THE ACUTE AND SUBACUTE OF MYOCARDIAL INFARCTION PERIODS
Authors: A.V. Golikov , A.S. Balabanov , A.S. Izmuhanov , A.V. Gordienko , B.A. Chumak , M.Z. Chochaeva
Published: November 2022

Relevance. Changes in the quality of life associated with heart failure (HF) in young and mid-dle-aged men with urological pathology and myocardial infarction (MI) are not well under-stood.
Aim. To evaluate changes in the quality of life (QL) indicator associated with heart failure (HF) in men under 60 years old with MI and acute urinary retention (AUR) to improve prevention and outcomes.
Material and methods. The study included men aged 19-60 years old with type I MI. Patients are divided into two age-comparable groups: I - the study group, with AUR - 22 patients; II - control, without it - 633 patients. A comparative analysis of the QL indicator associated with HF (HFQL) (V. Ironosov) was performed in the selected groups in the first 48 hours (I) and at the end of the third week (II) of MI. The changes and correlations (C. Spearmen) of HFQL with clinical features, metabolic parameters, central and peripheral hemodynamics were studied.
Results. HFQL in patients with AUR (85.7±15.6%) was worse than in the control group (59.4±20.1%; р˂0.0001) in the first hours of MI. At the end of the third week of the disease, no differences between the groups were observed (24.3±11.9 and 18.6±11.9%, respectively; p = 0.06). A positive (72 and 69%) dynamics of HFQL were obtained from the first hours to the end of the subacute MI period in both patient groups (р˂0.0001). In the study group, signifi-cant correlations of HFQL with the size of the left heart chambers, parameters of left ventricle systolic and diastolic function, peripheral hemodynamic, and lipid metabolism parameters were revealed. In the control group, more correlations were found, but their strength was less.
Conclusions. The quality of life associated with HF is worse in patients with AUR during the first hours of MI. Dilatation of the left heart chambers, left ventricle systolic and diastolic dys-function, no history of arterial hypertension, and hypocholesterolemia were the most associat-ed with quality of life in the study group. The assessment of HF-related quality of life is use-ful as an adjunct to the examination of patients with MI, starting from the first hours of the disease, for early identification of risk groups for adverse events and chronic HF formation.
TECHNOLOGY FOR OBTAINING A STANDARD SAMPLE OF RETINOL PALMITATE ISOLATED FROM NATURAL RAW MATERIALS, DETERMINATION OF THE MAIN INDICATORS CHARACTERIZING ITS QUALITY
Authors: E.B. Sysuev , V.D. Noskova , E.F. Stepanova , A.Yu. Petrov
Published: November 2022

This article discusses the issues of creating a standard sample (CO) with the use of a substance obtained from natural raw materials as a starting component, using the principles of lean manufacturing and affecting the problem of the production of domestic raw materials. The paper also discusses issues related to the standardization of the finished product, starting from the stage of choosing the material of the CO and ending with control at the stage of forming the material stock of products in a warehouse.
As the main model of the study, a material with retinol palmitate isolated from natural raw materials is used. We have used technological techniques for the production of the product under development with the use of step-by-step, starting from the stage of CO preparation, stability control according to the indicator "Uniformity", which in turn is one of the main quality characteristics. Classical manufacturing techniques of pharmaceutical products were used, quantitative and qualitative determination methods, high-performance liquid chromatography (HPLC) at a wavelength of 326 nm and IR spectroscopy in the radiation range of the spectrum from 4000 to 400 cm-1 were used to control the quality of the initial component.
A variant of the technological scheme for the production of vitamin A CO has been considered, this technology has been tested, and the received applicant has been standardized according to the main compliance indicators.
The developed SO allows, when conducting chemical research, to ensure metrological comparability and convergence of the analysis results between tests conducted not only by different chemical experts, but also between different laboratories and at different times, it is possible only with the use of measuring instruments of a standard sample (SO) with the appropriate certified characteristic for calibration. The use of CO in conformity assessment is one of the first conditions in the work of the laboratory for the recognition of its test results as reliable.
MARKETING ANALYSIS OF VACCINES USED FOR INFLUENZA IMMUNOPROPHYLAXIS IN THE REPUBLIC OF BASHKORTOSTAN
Authors: L.M. Gabdulkhakova , Zh.V. Mironenkova , S.Z. Umarov , L.M. Sharipova , K.M. Akpaeva
Published: November 2022

The study of cases of infectious diseases detected for the first time in the Republic of Bashkortostan (RB) revealed that in the group of infectious diseases, the nature of which is well studied, but the system of effective measures to combat them has not yet been developed, the greatest increase in morbidity in 2020 compared to 2015 was observed for influenza - by 341.16%. Therefore, the topic of marketing analysis on vaccines used in influenza immunoprophylaxis is relevant and timely. The analysis of the range of vaccines for the prevention of influenza was carried out by us according to the pharmaceutical market of the Republic of Bashkortostan, taking into account the information of the information and analytical system «State Register of Medicines» (GRLS) as of 08/23/2022 and presented by the 4th generation (generations). It was found that in the 2020/2021 epidemic season, relative to the 2015/2016 epidemic season, with a general decrease in the range of vaccines in the pharmaceutical market of the Republic of Bashkortostan, there was a 30.00% increase in the share of trivalent vaccines and 10.84% increase in the share of quadrivalent vaccines, the effectiveness of which increases the antigenic coincidence of influenza virus lines, the amount of costs prevented. Within the framework of the National Calendar of Preventive Vaccinations in the Republic of Bashkortostan, the transition to quadrivalent vaccines for immunoprophylaxis was not carried out, however, these vaccines were purchased by the population and organizations of Republic of Bashkortostan in pharmaceutical organizations for additional funds.
Estimation of single crop co-efficient for wheat crop using spectral indices
Authors: Saleh Syed Muhammad , Qureshi Abdul Latif , Shaikh Irfan Ahmed
Published: November 2022

The majority of the time, real crop water requirements are determined by combining references evaporation with crop coefficients. The crop coefficient accounts for plant transpiration and soil evaporation. The Kc values calculated with the lysimeter setup are point valued with no spatial fluctuation. Remotely detected spectral indices were used to estimate the crop coefficient in both space and time. As a result, this research was carried out to show that crop coefficients may be estimated using satellite data. The corrected satellite data for the research region were obtained/downloaded from the USGS website for the winter growing season (November to March). A hand-held GPS device was used to acquire ground truth valued. Plant heights of randomly selected plants were measured at 15 days intervals at the same time. The downloaded satellite data yielded two spectral indices: the Normalized Difference Vegetation Index (NDVI), and Soil Adjusted Vegetation Index (SAVI).to build relationships between Kc values and spectral indices, basic linear and multiple linear regression approaches were used kc and NDVI had a great individual relationship (R2=0.92) and SAVI (R2=0.79) while the combined association of NDVI and SAVI  (R2=0.94) was shown to be superior than each index’s standalone relationship. These relationships should be used to determine Kc values for wheat grown in dry areas with plenty of water.
Hubungan Antara Onset Kejadian Preeklamsia dengan Kejadian Bayi Lahir Berat Lahir Rendah (BBLR) di RSUD Provinsi NTB
Authors: Primayanti Ika , Affarah Wahyu Sulistya , Harahap Ida Lestari , Syari Mayuarsih Kartika , Wilmayani Ni Ketut
Published: November 2022

Pendahuluan: Preeklamsia merupakan salah satu komplikasi obstetrik yang dapat menyebabkan morbiditas dan mortalitas baik maternal maupun perinatal. Bayi Berat Lahir Rendah (BBLR) merupakan salah satu komplikasi perinatal yang dapat terjadi.

Metode: Penelitian ini merupakan penelitian observasional dengan desain cross sectional. Analisis data dilakukan dengan menggunakan uji statistik chi square.

Hasil: terdapat hubungan yang signifikan antara onset kejadian preeklamsia dengan kejadian BBLR (p= 0,000).

Kesimpulan: Penurunan perfusi uteroplasenta pada preeklamsia menyebabkan berkurangnya aliran darah plasenta sehingga pertumbuhan janin menurun dan meningkatnnya risiko bayi berat lahir rendah
Gambaran Konsumsi Garam Iodium dan Kadar Iodium Urin pada Anak Sekolah Dasar di Pulau Lombok
Authors: Ekawanti Ardiana , Lestarini Ima Arum , Cholidah Rifana , Fathana Prima Belia , Yuliyani Eka Arie
Published: November 2022

Pendahuluan: Defisiensi iodium masih merupakan masalah kesehatan masyarakat di seluruh dunia. Dari pemeriksaan iodium yang diekskresikan melalui urine, didapatkan defisiensi iodium pada 36,4% anak di seluruh dunia, dan daerah Asia Tenggara didapatkan 39,8% anak usia sekolah mengalami defisiensi iodium. Nusa Tenggara Barat adalah provinsi dengan konsumsi garam iodium yang terendah di seluruh Indonesia dan belum ada penelitian tentang kadar iodium urin dan factor yang mempengaruhinya.

Tujuan: Mencari data dasar tentang epidemiologi defisiensi iodium , selain itu penelitian ini juga bisa memberi manfaat tentang gambaran kadar iodine masyarakat secara umum..

Metode: Rancangan penelitian ini adalah rancangan potong lintang dengan populasi terjangkau kelas 5 dan 6 siswa SD di dataran rendah dan dataran tinggi Pulau Lombok. Faktor yang mempengaruhi tingkat konsumsi garam didapatkan dengan menggunakan kuesioner. Kadar iodium urin dinyatakan dengan median iodium urin yang didapatkan dengan menggunakan metode acid digestion.

Hasil: Median iodium urin di dataran rendah didapatkan 218 mg/L dan di dataran tinggi 236 mg/L. Iodium Urine Excretion di dataran rendah dan tinggi juga menunjukkan kecukupan tingkat konsumsi garam iodium.

Kesimpulan: Median iodium urin di dataran rendah didapatkan 218 mg/L dan di dataran tinggi 236 mg/L. Iodium Urine Excretion di dataran rendah dan tinggi juga menunjukkan kecukupan tingkat konsumsi garam iodium.
Tingkat Kepuasan Pasien Jamkesmas Terhadap Pelayanan Rawat Jalan Pusat Kesehatan Masyarakat Ampenan Tahun 2013
Authors: Astuti Anies Dyaning , Gerudug I Komang , Syamsun Arfi
Published: November 2022

Pendahuluan: Puskesmas merupakan pelayanan kesehatan lini pertama yang menyelenggarakan upaya kesehatan untuk meningkatkan kesadaran, kemauan dan, kemampuan hidup sehat setiap penduduk. Upaya kesehatan tersebut diselenggarakan dengan menitik beratkan pada kualitas pelayanan. Salah satu indikator kualitas pelayanan kesehatan adalah tingkat kepuasan pasien. Penelitian ini bertujuan untuk mengetahui dan menganalisis tingkat kepuasan pasien Jamkesmas terhadap pelayanan rawat jalan di Puskesmas Ampenan.

Metode: Desain penelitian ini adalah deskriptif analitik dengan rancangan cross sectional. Sampel diambil dengan consecutive sampling terhadap 70 pasien yang termasuk kriteria inklusi. Alat pengumpul data menggunakan kuesioner yang telah diuji validasi terlebih dahulu.

Hasil: Hasil penelitian secara umum menunjukkan tingkat kepuasan pasien pada variabel tangible didapatkan hasil tidak puas 4,3%, cukup puas 64,3%, puas 28,6%, sangat puas 2,9%. Berdasarkan variabel empathy didapatkan hasil tidak puas 1,4%, cukup puas 35,7%, puas 38,6%, sangat puas 24,3%. Berdasarkan variabel reliability didapatkan hasil tidak puas 1,4%, cukup puas 21,4%, puas 62,9%, sangat puas 14,3%. Berdasarkan variabel responsiveness didapatkan hasil tidak puas 1,4%, cukup puas 22,9%, puas 70%, sangat puas 5,7%. Berdasarkan variabel assurance didapatkan hasil tidak puas 1,4%, cukup puas 21,4%, puas 68,6%, sangat puas 8,6%.

Kesimpulan: Secara umum tingkat kepuasan pasien Jamkesmas adalah sudah merasa puas (53,74%) terhadap pelayanan rawat jalan di Puskesmas Ampenan.
Korelasi antara Status Gizi dengan Kadar Hemoglobin pada Anak Sekolah Dasar Negeri Telaga Lebur Kecamatan Sekotong Kabupaten Lombok Barat
Authors: Kurnia Dewanti Ida Ayu Diah Pramita , Lestarini Ima Arum , Priyambodo Seto
Published: November 2022

Latar Belakang: Malnutrisi dan anemia masih menjadi masalah kesehatan yang serius dan yang sering mengalami masalah ini adalah anak usia sekolah dasar. WHO pada tahun 2011 memperkirakan sekitar 43% dari anak-anak di seluruh dunia menderita anemia, dan di Indonesia kecenderungan prevalensi anak gizi buruk dan gizi kurang mengalami peningkatan dari tahun 2007 sampai tahun 2013. Penelitian ini bertujuan untuk mengetahui korelasi antara status gizi dengan kadar hemoglobin anak.       

Metode: Dalam penelitian ini digunakan rancangan penelitian survei analitik dengan pendekatan cross sectional. Subjek penelitian dipilih berdasarkan consecutive sampling  dan diperoleh sebanyak 67 anak Sekolah Dasar Negeri Telaga Lebur kelas 3 s/d 6 Kecamatan Sekotong, Lombok Barat tahun ajaran 2016 â€“ 2017. Kadar hemoglobin diukur dengan alat Point of Care Testing Hemoglobin, tinggi badan diukur dengan microtoise, dan berat badan diukur dengan timbangan injak. Data dianalisis dengan uji korelasi Spearman.

Hasil: Hasil penelitian menunjukkan bahwa 62,7% anak berstatus gizi normal, 25,4% kurus, 10,4% sangat kurus, dan 1,5% gemuk. Berdasarkan kategori kadar hemoglobin anak diperoleh 16,4% menderita anemia ringan, 35,8% anemia sedang, dan tidak ada yang menderita anemia berat. Hasil uji korelasi Spearman pada anak yang berstatus gizi kurang diperoleh koefisien korelasi sebesar 0,428 (p=0,033).

Kesimpulan: Terdapat korelasi antara status gizi dan kadar hemoglobin pada anak sekolah dasar kelas 3 s/d 6 Sekolah Dasar Negeri Telaga Lebur Kecamatan Sekotong Lombok Barat tahun ajaran 2016 â€“ 2017 dengan status gizi kurang.
Pengaruh Paparan Bising pada Proses Penggilingan terhadap Terjadinya Gangguan Pendengaran pada Pekerja Pertambangan Emas Skala Kecil di Kecamatan Sekotong.
Authors: John Ristania Ellya , Kadriyan Hamsu , Ekawanti Ardiana
Published: November 2022

Latar Belakang: Paparan bising pada pertambangan emas skala kecil terutama pada proses penggilingan dalam waktu yang lama dapat menyebabkan Gangguan Pendengaran Akibat Bising (GPAB). Data dan penelitian mengenai hal ini di Indonesia masih sangat kurang sehingga perlu dilakukan penelitian untuk mengetahui pengaruh paparan suara bising terjadinya gangguan pendengaran pada pekerja penggilingan emas skala kecil.

Metode: Penelitian ini merupakan penelitian deskriptif analitik dengan rancangan potong lintang yang dilakukan pada pekerja pertambangan skala kecil berusia 18-60 tahun di Sekotong. Penelitian ini diikuti oleh 90 responden. Pada subjek penelitian dilakukan wawancara untuk pengisian data dan pemeriksaan fungsi pendengaran dengan garpu tala pada frekuensi 512 dan 2048 Hz. Analisis data menggunakan uji chi square dan uji korelasi lambda.

Hasil: Berdasarkan hasil pemeriksaan garpu tala pada frekuensi 512 Hz ditemukan 24 pasien (26,7%) mengalami tuli telinga kiri dan 25 pasien (27,8%) mengalami tuli telinga kanan, sedangkan pada hasil pemeriksaan garpu tala pada frekuensi 2048 Hz ditemukan 53 orang (58,9%) mengalami tuli bilateral. Berdasarkan hasil uji chi square dan korelasi lambda diperoleh hasil bahwa pada frekuensi 512 Hz durasi kerja dan masa kerja berpengaruh signifikan terhadap terjadinya gangguan pendengaran pada pekerja tambang (p = 0,00), namun korelasinya sangat lemah (r = 0,00). Pada frekuensi 2048 Hz, durasi kerja berpengaruh signifikan (p = 0,00) terhadap terjadinya gangguan pendengaran pada pekerja tambang dengan korelasi yang kuat (r = 0,703), tetapi masa kerja tidak berpengaruh signifikan (p = 0,094).

Kesimpulan: Paparan bising pada proses penggilingan berpengaruh terhadap terjadinya gangguan pendengaran pada pekerja pertambangan emas skala kecil di Kecamatan Sekotong.
Hubungan antara Rasio Lingkar Pinggang-Panggul dengan Risiko Penyakit Kardiovaskular menggunakan Persentase Framingham Risk Score pada Populasi di Pulau Lombok
Authors: Alifiya Silmina , Indrayana Yana , Josafat Anom
Published: November 2022

Latar Belakang: Penyakit kardiovaskular sampai saat ini masih menjadi masalah kesehatan di berbagai negara baik di negara maju maupun di negara berkembang. WHO pada tahun 2014 menyebutkan penyakit kardiovaskular merupakan penyebab kematian terbanyak dari penyakit tidak menular yaitu sekitar 37%. Salah satu penyebab terjadinya penyakit kardiovaskular adalah obesitas abdominal. Obesitas abdominal dapat diukur dengan mengetahui rasio lingkar pinggang-panggul. Kejadian penyakit kardiovaskular dapat diprediksi menggunakan Framingham Risk Score. Penelitian ini bertujuan untuk mengetahui hubungan antara rasio ligkar pinggang-panggul dengan risiko penyakit kardiovaskular menggunakan persentase Framingham Risk Score.

Metode: Penelitian ini meggunakan rancangan penelitian deskriptif analitik dengan pendekatan cross sectional. Penelitian dilaksanakan di Lombok Epicentrum Mall pada bulan Oktober 2015. Sebanyak 69 subjek berusia 50-74 tahun yang memenuhi kriteria inklusi diikutsertakan pada penelitian ini. Tingkat risiko penyakit kardiovaskular diestimasi berdasarkan Framingham Risk Score yang meliputi usia, jenis kelamin, merokok, tekanan darah sistolik, diabetes mellitus, kolesterol HDL, dan kolesterol total. Data dianalisis dengan uji korelasi Spearman.

Hasil: Hasil penelitian menunjukkan bahwa 94,2% subjek memiliki rasio lingkar pinggang-panggul yang tidak normal. Dalam kaitan dengan risiko penyakit kardiovaskular yang dihitung dengan persentase Framingham Risk Score, 62,3% berisiko rendah, 23,2%  berisiko intermiediate, dan 14,5% berisiko tinggi. Berdasarkan uji korelasi Spearman diperoleh koefisien korelasi sebesar 0,390 dan signifikasni (p) sebesar 0,001.

Kesimpulan: Terdapat hubungan signifikan antara rasio lingkar pinggang-panggul dengan risiko penyakit kardiovaskular menggunakan persentase Framingham Risk Score pada populasi di Pulau Lombok.
Hubungan Kebiasaan Pemberian MP-ASI (Bubur Saring) terhadap Status Gizi Bayi Usia 6-12 Bulan di Wilayah Kerja Puskesmas Narmada Kabupaten Lombok Barat
Authors: Inayah Inayah , Nurbaiti Lina , Harahap Ida Lestari
Published: November 2022

Latar belakang: Makanan pendamping ASI adalah makanan atau minuman yang  diberikan pada usia 6-24 bulan untuk mencukupi kebutuhan gizi bayi. Rendahnya  pemberian  makanan tambahan yang tepat sesuai umur bayi menjadi salah satu pemicu rendahnya status gizi bayi dan balita. Kekurangan gizi merupakan faktor utama yang menyebabkan kematian pada bayi dan balita.

Tujuan: Untuk mengetahui hubungan kebiasaan (jenis, frekuensi, porsi, tekstur, ketepatan waktu) pemberian MP-ASI (Bubur Saring) terhadap status gizi bayi usia 6-12 bulan di wilayah kerja Puskesmas Narmada Kabupaten Lombok Barat.

Metode: Jenis penelitian ini bersifat analitik korelasi yang menggambarkan hubungan kebiasaan pemberian MP ASI dengan status gizi bayi. Penelitian ini menggunakan desain cross sectional. Jumlah sampel dalam penelitian ini adalah 51 responden.

Hasil: Profil status gizi subjek penelitian menunjukkan bahwa 49 bayi (96,1 %) memiliki gizi baik menurut BB/U, 47 bayi (92,2 %) memiliki gizi normal menurut PB/U, dan 49 bayi (96,1 %) memiliki gizi gizi normal menurut BB/PB. Hasil uji spearman pada variabel frekuensi, dan porsi pemberian MP-ASI diperoleh nilai signifikasi >0,05, dan hasil uji chi-square pada variabel ketepatan waktu, jenis dan tekstur pemberian MP-ASI diperoleh nilai p â‰¥0,05, sehingga tidak didapatkan adanya hubungan antara kebiasaan (jenis, frekuensi, porsi, tekstur, ketepatan waktu) pemberian MP-ASI terhadap status gizi pada bayi usia 6-12 bulan di wilayah kerja Puskesmas Narmada Kabupaten Lombok Barat.

Kesimpulan: Hasil penelitian ini menunjukkan tidak terdapat hubungan signifikan antara kebiasaan pemberian MP-ASI (Bubur Saring) terhadap status gizi bayi usia 6-12 bulan di wilayah kerja Puskesmas Narmada Kabupaten Lombok Barat.
EFEKTIFITAS PEMBERIAN TRAMADOL 37,5mg + PARACETAMOL 325mg per oral DIBANDINGKAN KETOPROFEN 100mg supp UNTUK MENGURANGI NYERI SELAMA 24 JAM PADA PASIEN PASCA OPERASI BEDAH DI RS. BHAYANGKARA MENGGUNAKAN VAS Skor
Authors: Hardiansyah Nanang Bagus , Kresnoadi Erwin , Nandana Pandu Ishaq
Published: November 2022

Latar Belakang: Nyeri pasca bedah disebabkan oleh adanya rangsangan mekanik luka yang menyebabkan tubuh mengeluarkan mediator â€“ mediator kimia nyeri dan bervariasi mulai dari nyeri ringan sampai nyeri berat namun menurun sejalan dengan proses penyembuhan. Tramadol+paracetamol dan Ketoprofen merupakan obat yang dapat digunakan untuk mengurangi nyeri pasca operasi bedah. Kombinasi Tramadol + paracetamol menghambat sintesis prostaglandin dalam sistem saraf pusat dan nyeri blok impuls pada sistem saraf perifer dan ketoprofen berkerja dengan penghambatan jalur siklooksigenase dari metabolisme asam arakidonat.

Tujuan: Penelitian ini membandingkan efektifitas tramadol 37,5mg + paracetamol 325 mg  peroral dan ketoprofen 100mg supp dalam mengurangi nyeri pasca operasi bedah umum.

Metode: Metode Penelitian ini observasi klinik karena sampel penelitian diobservasi sampai waktu tertentu untuk melihat efek yang timbul pada sampel penelitian. Total 48 pasien, yang terbagi dalam 2 kelompok. Kelompok Tramadol 24 pasien dan Kelompok Ketoprofen 24 pasien. Data Disajikan dalam bentuk nilai rerata Â± simpang baku, kemudian diuji dengan menggunakan uji Mann Whitney dan Independent t-Test dengan (Î± = 0,05).

Hasil: Penurunan derajat nyeri pada pasien pasca operasi bedah umum yang diberi tramadol 37,5mg + paracetamol 325 mg  peroral lebih efektif dibanding dengan ketoprofen 100mg supp, p=0,000 (p,0,05).

Kesimpulan: terdapat perbedaan bermakna antara kelompok tramadol + paracetamol dan kelompok ketoprofen dalam menurunkan derajat nyeri, p=0,000 (p,0,05).