bluuebunny/crossref_metadata_2025 huggingface dataset:
Hope toward potent drug target using tertiary topological instances of Mycobacterial transmembrane protein
Authors: Baig Mohd Asjad
Published: February 2023

Integral membrane proteins are important for various cellular processes. They are the major part involved in the transportation of different proteins across the membrane and thus might also be helpful in maintaining the charge potential. Rv0882 was predicted to be an integral membrane protein by various bioinformatics analyses. TBpred servers characterize the presence of this protein in the transmembrane region. SOSUI, TMHMM and HMMTOP servers found various transmembrane regions of this protein at various positions. TOPCONS web server provides the presence of an alpha-helical region in this protein. Secondary structure prediction and Three-dimensional (3D) modeling of this protein were done by using PSIPRED and QUARK respectively. Prediction of ligand binding site shows that various residues of this protein bind to different compounds whose results are confirmed by molecular docking of these compounds with Rv0882 protein. This protein also comprises a Fibronectin binding motif (RWFV) which also suggests that this protein might also act as a Fibronectin binding protein (FnBp). Previous studies proved that integral membrane proteins are important for transportation and FnBp are involved in host-pathogen interaction. Thus, studying this gene might be beneficial for stretching information about an untouched site of this bacterium which might be helpful in declining this infection.
Application of aldehyde solutions of weak concentrations in complex therapy of infected wounds of extremities
Authors: UA Ivantsou , AU Ivantsou
Published: February 2023

This article shows that a mixture of glutaric and formaldehyde solutions of low concentration (0.05%-0.25%) has a synergistic effect, suppresses the reproduction of microbial populations, leads to a pronounced bactericidal effect and prevents the development of wound infection.
Tenotomy of deep belly of the temporalis muscle for treating acute trigeminal neuralgia
Authors: Mohamed Sara Zaky
Published: February 2023

Background: The author describe a technique for tenotomy of Deep Belly of the Temporalis muscle for treating acute Trigeminal Neuralgia of the maxillary branch. Methods: Eight with trigeminal neuralgia at maxillary branch without another reason to suffer this disease. After a 1-cm inner side of cheek incision is made, blunt dissection is performed toward the Coronoid Process. The inferior tendon of deep belly of the temporalis muscle was identified and it was cut. Results: This eight patients obtained a value of VAS=0 and completely resolution of theirs painful condition and functional resolution at two months after the surgery. Conclusions: Tenotomy of deep belly of the temporalis muscle is a good method to treat acute TN specially when 1) Were discarded all the different causes of Trigeminal Neuralgia of maxillary branch 2) Exist a close relationship between deep belly of the temporalis muscle and maxillary nerve.
Relationship of step section and accuracy of pathologic diagnosis of thyroid cancers
Authors: Amir Majdi N Mokhtari , Derhami V , Golrokhian Sani Mohammad Reza
Published: February 2023

Objective: This case history shows the significance of the step section to be performed on any extra thyroidal neck mass containing thyroid tissue. The material for pathologic diagnosis was a neck mass removed from the left tracheoesophageal groove in a 43-year-old lady whose right hemithyroidectomy was performed by the authors fourteen years ago (Mrs.D.).Her previous pathologic report was follicular adenoma. The report on her new pathologic specimen was" benign thyroid tissue." However, this report did not match her previous medical history, and we requested a step section (extensive levelling) to be performed on the specimen. Her final pathologic diagnosis was "near-total replacement of a lymph node by well- differentiated thyroid carcinoma." She underwent a total thyroidectomy and central neck dissection, followed by our nuclear medicine team for seven years.
Long-term follow-up of Egyptian adolescents and young adults with Auditory Processing Disorders (APD)
Authors: Tawfik Somaia , Elkabarity Rasha , Hanna Diana
Published: February 2023

Objective: To study the long-term follow up of young adolescents and adults formerly diagnosed with central auditory processing disorders. Design: An Arabic version of the University of Cincinnati Auditory Processing Inventory questionnaire (UCAPI) was developed and standardized on normal Arabic speaking adolescents and adults. It was applied to patients with auditory processing disorders (APD) in order to evaluate the long-term outcome of APD subjectively. Moreover, psychophysical central auditory tests(Arabic speech in noise test, Arabic dichotic digit test, pitch pattern test, auditory fusion test and auditory memory tests were used as Objective measure for monitoring long term outcome. Results: Standardization to the developed Arabic version of UCAPI questionnaire was done in the control group. Comparing scores of the study and control groups, independent t test showed highly statistically significant differences on all questionnaire categories. Normal composite score of psychophysical central retest results in the study group was 63.3%. Conclusion: APD is a life-long disorder. In spite of the marked improvement of the central test results, patients show residual functional deficit as evidenced by the questionnaire. The Arabic version of UCAPI Questionnaire is a good and efficient tool diagnosing and monitoring APD in adolescents and adults.
Posterior cordotomy in bilateral vocal cord paralysis
Authors: Ruggeri Carlos Santiago , Latourrette Dora Cristina
Published: February 2023

Introduction: Bilateral vocal cords paralysis in adduction when it is irreversible requires treatment due to the inspiratory dyspnea that produces. Different surgical techniques can be used to increase the glottic space. Posterior cordotomy with partial arytenoidectomy improves dyspnea and is one of the most used surgeries. Objectives: To determine the resolution rate of inspiratory dyspnea or decannulation, in patients with bilateral vocal cord paralysis in adduction treated with posterior cordotomy and partial arytenoidectomy Methods: A retrospective and descriptive study was carried out by analyzing the electronic medical records of all patients who had bilateral vocal cords paralysis in adduction and were treated with posterior cordotomy and partial arytenoidectomy between March 2004 and December 2018. The result of the posterior cordotomy with partial arytenoidectomy was determined according to the decannulation rate of the patients who had tracheostomy, according to dyspnea resolution after the cordotomy and by the increase of the postoperative glottic space evidenced by endoscopy. Results: Nineteen patients were treated by bilateral vocal cord paralysis in adduction. The most frequent cause was a total thyroidectomy (9/19). Eight had a tracheostomy prior to posterior cordotomy. Seven of eight patients who had tracheostomy were able to decannulate, the rest had insufficient glottic space and did not return to control. All patients without tracheostomy (11/19) improved their inspiratory dyspnea and had no limitation for their daily life activities. Conclusions: The resolution of inspiratory dyspnea in patients with bilateral vocal cords paralysis in adduction without tracheostomy, treated with posterior cordotomy and partial arytenoidectomy was 100% (11/11). In tracheotomized patients the decannulation rate was 87,50% (7/8).
PFAPA syndrome: A practical review
Authors: Caneira Tiago , Subtil João , Saraiva José
Published: February 2023

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is rare, benign recurrent/periodic fever syndrome of unknown etiology that normally affects children under the age of 5. The diagnosis is made based on clinical assumption, after excluding other pathology. In this report to provide a practical assessment of PFAPA syndrome regarding epidemiology, pathogenesis, natural history, clinical manifestations, diagnosis criteria, differential diagnosis, and available medical and surgical treatments.
Psycho diagnostic techniques for the study of parent-child relationships as a tool of psychological counseling
Authors: Olga Karabanova
Published: February 2023

The article presents the experience of using the projective technique “Parent essay” and tests for assessment parent-child joint activity. Indicators for assessing the parental attitudes and parent-child relationships are presented. A scheme for drawing up a conclusion is presented, highlighting the main blocks describing the parenting and parent-child relationships
A correlation study of job satisfaction and quality of work life of the employees working in a mental health institution
Authors: Kumari Pathak Sveta , N Navya , Sindhu Brahmdeep , Puri Amita , Sindhu Nehal
Published: February 2023

The healthcare sector has not been untouched by globalization over the years. On observing the healthcare delivery and medical education in today’s scenario, it has been observed that there have been a lot of modifications in professional roles as well as boundaries. The job satisfaction of the employees working in mental health institution plays a vital role on their quality of life. The present study has aimed to explore the correlation of job satisfaction and quality of lifeamong employees working in mental health institution. A sample of 100 employees working in mental health institution completed a set of the two structured questionnaires by World Health Organization (quality of Life) and B.L Dubey (Job satisfaction) through Purposive and Snowball sampling. The findings provide evidence on the possible factors that the healthcare organizations need to focus on, to ensure the job satisfaction of employees. There was a significant impact of job satisfaction on mental health
On rare and unusual types of dissociative disorders: a case of dissociative episodes with time travel-like experience
Authors: Waquad Aisha , Khan Tasmia , Lewis Layth , Bhatnura Kulwinder , Azizi Heela , Yucel Deniz , Jayaraj Sinthuja , Lumbrazo Kenneth , Singh Navpreet , Taugir Rahima , Cherukupally Karthik , Jolayemi Ayodeji
Published: February 2023

The Spectrum of Dissociative Disorders are based on criteria that define the dissociative experience of depersonalization along the spatial dimension with patients having dissociative episodes typically describe the experience of being spatially removed from the first person experience. We present the unique case of a patient with Other Specified Dissociative Disorder who exhibits depersonalization in relation to the dimension of time, with no clear spatial depersonalization. We discuss our findings in light of research on disturbances in temporal perception in patients and the implication for future criteria for Dissociative Disorders
Autologous bone marrow derived mononuclear cells for the treatment of drug resistant epilepsy
Authors: A Hammadi Abdulmajeed
Published: February 2023

Epilepsy is a neurological disorder characterized by two or more unprovoked seizures with abnormal brain activity, Cognitive and behavioral changes usually accompanies epilepsy, like hallucinations delusions and apathy. Of all cases of epilepsy 30% are resistant to conventional treatment. Drug resistant epilepsy is defined as recurrent seizures refractory to a regimen of two or more antiepileptic drugs. Stem cell therapy is a possible alternative with minimal side effects; it is currently used for treatment of variety of diseases including neurological disorders like multiple sclerosis and stroke. In this clinical study, 20 Iraqi patients included, aged 2-39 year. 8 females and 12 male with multidrug resistant epilepsy, at least after 3 months of diagnosis and treatment. The 20 patients were kept on drugs, more than 2 drugs 80%, 2 drugs 20%, all the patients underwent autologous bone marrow mononuclear cells infusion intravenously. Mononuclear cell counts ranges from 2-4 x10 8 per product with 97 % viability. Two sessions done in 8 weeks' time. Out of 20 patients 13 patients showed improvement (65%) in seizure activity in form of 50-100% reduction in 6 months after stem cell therapy, in addition there was improvement in appetite and sleep rhythm. Autologous bone marrow derived mononuclear cells systemic infusion is a safe clinical procedure with promising results in drug resistant epilepsy.
Live cell therapy: historical aspects, mechanisms of action, safety and success stories
Authors: Klokol Dmitry , Chan Mike KS , Wong Michelle BF , Nallenthiran Lingeswran , Chernykh Volodymyr , Yefimov Simon , Nalapko Yuriy , Pan Patricia
Published: February 2023

Therapeutic applications of xenogeneic remedies and various forms of cell therapy can be traced back in history for many centuries. However its clinical application in conventional medicine started in the beginning of 20th century from Switzerland and Germany. Current paper highlights the milestones of development of live cell therapy as a paradigm of regenerative medicine, discusses mechanisms of its biological function, safety of cell therapy and offers a series of case reports.
Stem cell repertoire in the prostate epithelium
Authors: Pandey Deepak , Choudhury Ankit Roy , Kumar Neeraj , Kumar Sandeep
Published: February 2023

Over the past two decades, the roles of stem cells have been studied in the contexts of developmental biology, tissue engineering, cancer therapy, neurodegenerative disorders and what not! Right since the discovery of prostate specific adult stem cells or stem-like cells in both stromal and epithelial compartments, their participation in prostate development and prostatic pathologies (like benign prostatic hyperplasia and prostate cancer) are being thoroughly investigated. The present mini-review summarizes the ins and outs of the histological organization of acinar prostate and prostate cancer, keeping the prostate-specific epithelial stem cells on the backdrop.
The effect of mesenchymal stem cells and exosomes to treat idiopathic pulmonary fibrosis
Authors: Gallicchio Vincent S , Chase Daina M
Published: February 2023

Idiopathic Pulmonary Fibrosis (IPF) is a disease that consists of the scarring of the lungs. It is the most common type of pulmonary fibrosis. This disease is irreversible and becomes worse over time. In patients with IPF, treatment relies mostly on the clinical application of new drugs. Unfortunately, these drugs do not repair damaged lung tissue; therefore, these medications only have the ability to slow down disease progression. With this dilemma, stem cell treatment has become a popular alternative in the treatment of IPF, specifically mesenchymal stem cells (MSCs). MSC therapy would repair damaged lung tissue, thus not delaying the progression of the disease, but instead repairing the lungs of the patient. In addition, the application of exosomes has also gained popularity because of their functionality in intracellular communication. There is a need for regenerating the damaged lung tissue of patients with IPF, which can be accomplished with stem cell therapy. The clinical application of MSCs has been proven safe in patients with this degenerative disease, thus this finding has justified more research for the application of stem cell therapy in patients with IPF.
Radiation induced therapeutic effects in cancerous and tumor cells: A review
Authors: Upadhyay Ravi Kant , Rai Priya
Published: February 2023

Present review article describes use of radiation and radionuclides on cancer and cancer cell therapeutics. It also sketches out cumulative effects of radiation exposure received by the patients during cancer diagnostics. Though, in cancer therapeutics a selected and permissible dose is provided in several cycles to ablate the neoplastic cells and improve the condition of patient, but radiation harms surrounding cells and imparts negative effects on biology of cells. Ionizing radiation (IR) promotes cancer cell death through cytotoxicity. This article emphasizes both remedial effects and biological effects of radiation and radio-resistance in cells. It suggests safe use of radionucleides by encapsulating them in nanomaterials so as to use it alternate to chemotherapy to destroy various cancer types to enhance the survival of normal cells. This article explains effect of ionizing and non-ionizing radiation on cellular metabolism and genetics.
A review of gender and technologies: case of central Uganda
Authors: Kiggundu Nicholas , Menya James , Banadda Noble
Published: February 2023

Although different technologies are developed and used by both men and women, less has been done in the analysis of gender consideration during technology development. As economies reposition themselves to compete in the global economy, the gender gap in technology development and adoption has caught the attention of planners. When projects include gender sensitive components the ability to defend the interests of women and men can be increased. The objective of this paper is to develop a strategy of gender incorporation in technology development. A literature review of case studies was done. In conclusion, the development of technologies is generally not based on a comprehensive analysis of gender roles. Additionally, technology development projects do not offer equal participation of both genders during execution of technology development projects due to the fact that on addition to productive activities, women also dedicate some of their time to reproductive activities in their families.
Cardiac and respiratory signal extraction methods from ballistocardiography signal sensed using fiber bragg grating sensor
Authors: K Chethana , Prasad AS Guru , SB Nagaraj , S Asokan
Published: February 2023

This work presents a simple, efficient and an easy-to-build ballistocardiography sys-tem using Fiber Bragg Grating (FBG) sensor and a comprehensive assessment of relevant digital signal processing algorithms to simultaneously extract respiratory and cardiac frequency components from a cluttered mix Ballistocardiography (BCG) signal. The primary purpose of the current study is two-fold: first- to build an analog circuit for BCG signal amplification, and second to evaluate the performance of three state-of-the-art methods, namely: lowpass-highpass filter, weiner filter and ensemble empherical mode decomposition to simultaneously extract respiratory and cardiac frequency components from the BCG signal. BCG measurements from test subjects were used in this study and a commercial digital stethoscope was used to validate the performance of methods used in this study. In addition to the effective amplification of the BCG signal through proposed analog circuit configuration, we demonstrate that a simple low pass high pass filter configuration can be used for accurate measurement of cardiac and respiratory frequencies. Due to its simplicity, the proposed system can be suitably tailored to process BCG signal for simultaneous extraction of respiration and heart rate which can aid as an effective diagnostic tool for identifying critical disorders associated with lungs and heart dysfunction.
Detecting emotional ambiguity in text
Authors: Jenkins Jeffrey
Published: February 2023

An approach for determining emotional ambiguity in text data is described in this paper. The prediction confidences output from a text classifier are used to measure amount of ambiguity found in target entries. This measure can be used as a filtering mechanism to identify entries that require human feedback. This feedback loop can be implemented in a workflow which retrains a classifier model including newly disambiguated entries and resulting in a boost to classifier accuracy. This emotion ambiguity measure can be utilized to discover concrete emotional content in text data as well as reveal topics which do not have a concrete emotional consensus.
COVID-19 detection using SERS technique
Authors: Magdy Caroline , Issam Fatma , Amir Pierre , Adel Sandra , ElGohary Sherif H.
Published: February 2023

Using Surface-enhanced Raman spectroscopy (SERS) can be a more promising choice for obtaining a faster detection of COVID-19 than the PCR. PCR protocol amplifies the single segment of DNA to 100 billion copies after 40 doubling cycles to provide sufficient intensities of fluorescent signals for virus detection, which takes hours. In this paper, we proposed that the enhanced signals of SERS, which can identify single nucleotide polymorphisms and unique gene sequences, can provide a more economic and accurate detection that does not require the long time needed for DNA amplification of COVID-19. Our proposed diagnostic tool is based on technology of single molecule SERS which checks if the Raman shift of the sample signal matches with the recorded one of COVID-19. In addition, its portability property provides the allowance of its usage in places other than labs and healthcare facilities. Therefore, the superiority of using SERS over fluorescence is manifested in the acquirement of a few-minute detection of coronavirus by the action of a SERS laser rather than the long and expensive measures taken in PCR.
Exploring hormone communication and perception of emotion
Authors: Jenkins Jeffrey , Ching Chang Lin- , Q. Tran Binh , Szu Harold
Published: February 2023

Are the biological mechanisms that facilitate perception of external photon stimuli using the sense of sight also responsible for the perception of internal hormone stimuli using the instinctive sense of emotion? Different regions of the body influence one another by communicating on the molecular scale with small electrical ions as well as larger chemical macromolecules such as hormones. For example, the detection of a predator causes hormones to be produced throughout the body, leading to a rapid physical response. To model such a system, we divide biological phenomena into two stages: sensing and communication, where each stage uses electrical ions and various molecules as signals. Designing a biomimetic computer system that can perform such a task is currently a challenge due to the large size of biological macromolecules and the small size of digital electronic components that are suited for electrons. We derive a general molecular communication theory to describe the interaction of molecules on different time and space scales with a thermodynamic model of hormone equilibration based on the Minimization of Helmholtz Free Energy (MFE). Our work paves the way for future cutting-edge AI systems to utilize heterogenous units of information and as a result, more accurately resembles the style of computation performed by biological systems.
Can AI emulate slow & fast thinking?
Authors: Szu Harold , Keuthan Lynn , Jenkins Jeffrey
Published: February 2023

Artificial Intelligence (AI) attempts to emulate natural intelligence of Homo sapiens. Sometimes, the wise men have biases. This review pointed out the gaps, and the shortfalls to develop new AI. Currently, given the technology of the 5th G. m.m.w. communication broadband channel, real-time smart sensory inputs with rapid electronic processing become possible to overcome some gaps reasonably. The questions remain are whether AI can capture the chemical signals, such as hormones effects? We provide the motivation for AI developers care to overcome these shortfalls? (1) Financial Reasons: Space travel can have intelligent as well as emotion-sensitive robots to colonize the Space sites. (2) Earthbound Humanity Reasons: Aging WWII Baby Boomers about 100M and most of them about half without offspring to take care them, they will live long contribute their experience and wisdom but will need Humanoids take care of them with the understanding of their loneliness emotional needs.
Expanding the amplitude of propolis uses
Authors: Salatino Antonio
Published: February 2023

Propolis is an apiculture product containing beeswax, bee saliva and resins that bees collect from selected plants. Among the various uses of propolis by the hive, protection against natural enemies, chiefly of microbial origin, stands out, contributing to enhance the hive immunity and resistance against infection. Most known types of propolis have phenolic substances as main resin constituents. Several phenolic compounds from propolis including flavonoids, are active against bacteria. Experiments and clinical practice have shown that propolis is helpful in several areas, the antibacterial activity of propolis constituents being the driving force of the performance. Propolis extracts have been used as preservative of several kind of animal and plant derived foods, food packages, as well as in veterinary, dentistry and therapies for human care against infectious diseases. Propolis extracts have been used experimentally as adjuvant in antibiotic therapy against infectious diseases, with positive results regarding reduction of effective doses of the antibiotic, and is expected as well to reduce the risk of development of bacteria resistance against antibiotics. Hospital therapies have benefited of the association of propolis extract as adjuvant with drugs used in the treatment of COVID-19. Fostering the uses of propolis in therapies require the development of active fractions of propolis, containing a limited number of constituents and exact qualitative and quantitative constitution.
Development of the family support scale (FSS) for elderly people
Authors: Uddin Mohammad Abbas
Published: February 2023

The situation of elderly people is an increasingly pressing global concern. This issue is especially challenging for developing countries, where, traditionally, the majority of the elderly people have lived with their family and have been dependent on family support. Nowadays, however, appropriate family support is no longer guaranteed. An assessment tool for measuring active family support would be useful for describing the real living situation of the elderly. The purpose of this study was to develop an active family support scale for elderly people in Bangladesh. This study’s participants were 20 elderly people (aged from 65 to 75 years) who were asked about the support they perceived that they receive from their families. The proposed instrument was found to be a reliable family support scale for Bangladeshi elderly with an internal consistency reliability level of 0.94 (Cronbach’s Alpha Coefficient). The study’s findings are considered transferable to other developing countries. The scale can be used to assess elderly people’s perceived family support in Bangladesh and other developing countries and can support initiatives to improve family support.
Impact of behavioral and psychological symptoms of dementia (BPSD) in institutionalized people
Authors: Hernandis Sacramento Pinazo
Published: February 2023

Background & aims: The behavioral and psychological symptoms associated with dementia are very disruptive and take on more and more relevance given the problem they pose to the people who suffer from them and their environment. In many cases these symptoms can be the trigger for caregivers to use physical or chemical restraints to alleviate the intrinsic and extrinsic damage they can cause. This work aims to evaluate the appearance of these symptoms, the prescription of psychotropic drugs, and other psychofunctional variables that may be related, such as the cognitive, functional or emotional state, in institutional settings. Methods: The relationship between these variables and age and gender has also been evaluated. The sample consisted of 450 institutionalized elderly people. Results: The data obtained indicate a large percentage of people who present behavioral alterations and an over-prescription of psychotropic drugs. The majority of the sample is made up of women which present moderately severe fall rates, functional levels of dependence, cognitive impairment and emotional states. With regard to the relationships found, age is related to greater consumption of psychotropic drugs and worse gait stability. In terms of gender, women are the most medicated, with the worst cognitive, functional status and worse gait stability. The presence of BPSD is directly related to the consumption of psychotropic drugs and other psychofunctional variables such as greater cognitive impairment, functional dependence or worse mood. Conclusion: It is necessary to design non-pharmacological interventions in institutional settings that influence the analyzed variables to improve people's well-being and quality of life.
Opioids, allies in musculoskeletal pain management
Authors: Ringer Ariana , Sebastian Mout , Jaimet Celia , Willems David , Aranalde Gabriel , Ruffino Juan Pablo , Harvey Guillermina
Published: February 2023

Pain management is a fundamental pillar of medical practice. The most commonly controversial drugs used for its treatment are opioids. It is of utmost importance to know how to use them. The aim of this study was to describe the characteristics of treatment with opioids in a third level attention hospital on patients hospitalized in Internal Medicine, during a four months period. A total of 202 patients were evaluated. Most of them, experienced moderate (85/202, 42.08%) to severe (106/202, 52.48%) acute (160/202, 79.21%), somatic nociceptive (93/202, 46.04%) and mixed pain (105/202, 51.98%). In the vast majority of the cases, the opioid indication was adequate to the pain intensity (191/202, 94.55%), and the doctor who indicated the treatment took this into consideration before deciding what type of drug to use (177/202, 87.62%). Opioids were mainly indicated for musculoskeletal postoperative pain (68/202, 33.66%), neoplasms (31/202, 15.35%) and muscular and osteoarticular system disorders (28/202, 13.86%). The most widely used was tramadol (142/202, 70.30%), followed by morphine (48/202, 23.76%) and methadone (10/202, 4.95%). Intervals, rotations and dosis in patients with renal and hepatic dysfunction were, mostly, correct. Rescue therapy and its drawbacks were also analyzed. Antiemetics and cathartic medicaments were prescribed in less than half of the cases (86/202, 42.57% y 90/202, 44.55% respectively). Most frequent side effects were constipation (80/202, 39.60%), nausea (43/202, 21.28%), vomiting (28/202, 13.86%), sedation, drowsiness and lethargy (38/202, 18.81%). Pain must be understood as a multidimensional area and a correct and complete approach must take a wide variety of possibilities into account.
Rapid palatal disjunction: a solution beyond dentomaxillofacial orthopedics
Authors: Céspedes Yaniris Figueroa
Published: February 2023

Introduction: One of the most impressive orthopedic procedures is the transverse separation of the maxilla, through the rapid palatal disjunction (RMD). Effective alternative routinely used in the correction of transverse skeletal deficiency in the upper jaw, but it has been showing results that exceed the framework of Orthopedics and Orthodontics. This has recently motivated interesting renovations for the development of Orthodontics, so our Objective is to determine how rapid palatal disjunction constitutes a solution beyond dentomacilofacial Orthopedics. Material and methods: A search was carried out in 8 electronic databases of the systems (MEDLINE, PubMed, Hinari Cochrane, PubMed, SciELO, Scopus and Google Scholar). The articles reviewed were 59 articles, of which 25 were selected for the investigation. Most relevant results. These studies reflect that it constitutes an effective therapeutic procedure, which facilitates the rapid increase in arch length to alleviate posterior inverted occlusions, without adverse effects on the facial profile and, therefore, the correction of disharmonies in the transverse plane is achieved. .The secondary effects that provide the general well-being of the patient are also described. Thus showing the need to be analyzed from a more comprehensive approach. Conclusions: The ERM is a solution that goes beyond maxillary, dental, deeper cranial structure changes, soft tissues, airways, and cervical posture, but also improves the patient's quality of life (compared to sleep apnea, snoring, auditory function, nocturnal enuresis, atypical absences, tiredness, posture, behavior and even intelligence quotient ( IQ)).
An aberrant palmaris brevis causing ulnar nerve compression at guyon’s canal: An anatomic case report and literature review
Authors: Saito Rex , Beckett Ryan , Frazier Joel
Published: February 2023

There have been reports of ulnar nerve compression due to anatomic variations at Guyon’s canal. Knowledge of certain variations at Guyon’s canal may help hand surgeons identify possible unconventional compression sites of the ulnar nerve. We present a case report of a patient with an aberrant palmaris brevis muscle belly that was found to cross over the proximal aspect of the ulnar tunnel neurovascular bundle potentially causing ulnar nerve symptoms. Surgical interventions with the release of the palmaris brevis muscle belly and transposition to the flexor carpi ulnaris tendon at the level of Guyon’s canal helped provide relief of the patient’s ulnar nerve symptoms.
Mathematical modeling of indications for pelvic and proximal femurosteotomy in patients with cerebral palsy based upon clinical and radiographic parameters of the hip joint
Authors: Bogdanovych Yatsuliak Mykhailo
Published: February 2023

Relevance. A differentiated approach to pelvic and proximal femur osteotomy in hip disease among patients with cerebral palsy is a relevant subject of study. The aim of the study. Diagnostic improvement in diseases of the hip joints in cerebral palsy to create a differentiated approach to the reconstruction of the pelvis and proximal femur osteotomy based upon mathematical modeling. Materials and methods. The total number of patients was 33 patients (60 joints). We conducted a clinical and radiographic examination of the hip joints using our own method and standard anterior-posterior radiographs, determining the parameters of the hip joint. Mathematical modeling of indications for proximal femur osteotomy and combination of pelvic and proximal femur osteotomy using logistic regression was also performed. A mathematical model entitled "Probability of indications for pelvic and proximal femur osteotomy " based upon acetabular angle (AA), Reimers' index (RI), GMFCS level and ambulation for both positionings was developed. We have offered a mathematical model for determining indications for pelvic and hip osteotomy in hip joint diseases among children with cerebral palsy for a standard anterior-posterior radiograph based upon AA, RI, GMFCS level and ambulation with a model accuracy 91.1%. The critical level of indicators in which indications for pelvic and proximal femur osteotomy are detected is for AA > 23.55 ̊, for RI > 34%.
Effectiveness and baseline predictive factors for Tofacitinib response in rheumatoid arthritis in a real-world setting: A national multicenter study
Authors: JP Vinicki , R Gomez , MR Maliandi , Zamora JL Velasco , YS Malvano , MA Cusa , MJ Gamba , J Got , O Gut , V Paris , MA Spinetto , NC Mariasch , AI Abalo , AJ Estevez
Published: February 2023

Background: Evidence of effectiveness and safety of tofacitinib (TOF) in the real-world setting in Latin America is currently limited and crucial to complement long-term extension data from randomized controlled trials. Methods: Patients initiated on TOF between 2014 and 2020 with RA (ACR/EULAR, 2010 criteria) were analyzed. The primary end point at month 3 was remission measured by DAS28-ESR. Secondary end points included prognostic factors for remission at 3 months and of monotherapy at month 12. Results: Overall, 134 RA patients were analyzed. Remission was achieved in 38.06% at month 3. In univariate analysis, persistent disease activity at 3 months was observed in those patients with longer duration of disease, structural radiological damage, higher baseline DAS28-ESR and greater frequency in previous use of bDMARD. In multivariate analysis, previous use of bDMARD was significantly associated with a decrease in the probability of remission at 3 months. At 12 months, TOF monotherapy group was elderly (p = 0.009) and had a trend for lower frequency of anti-CCP. Treatment persistence was 94.78% at 3 months, 82.84% at 6 months and 66.42% at 12 months. Conclusions: Clinical remission at 3 months was negatively associated with prior bDMARD and poor prognostic factors. TOF monotherapy at 12 months was more common in elderly patients.
Unstable thorax in a polytraumatized patient: Case report
Authors: García Cabra Damaris Areli , Villavicencio Jiménez Daniel Adrián , Fidencio David Jerez
Published: February 2023

Unstable thorax is a serious pathology that requires a clear and current knowledge of the principles for its management. We present the case of a male patient diagnosed with unstable/polyfractured thorax (rib, hip and metaphyseal fractures of the radius and ulna). On admission, he presented mild pulmonary contusion without respiratory failure; managed with conservative treatment to the unstable thorax and osteosynthesis of hip fracture, achieving satisfactory evolution. We present the current recommendations for the therapeutic management of unstable thorax, the indications for surgical and conservative management are defined, as well as the injury severity indexes as indicators of mortality.
Analytic validation of a formula estimating the smoking economic burden
Authors: Hernández Fé Fernández , González Efraín Sánchez
Published: February 2023

Introduction: The precise estimation of epidemiologic and economic rates contributes to make better the whole process of taking decisions for the effective smoking control. In 2017 the authors published a new formula to estimate the probability for the effective demand of health services attributable to smoking. This rate is very important because show the representativeness from the smoking economic burden in the burden of sickness related to smoking. Objective: To check analytically the ability of the rate of probability for the effective demand of health services attributable to smoking suggested by the authors. Materials and methods: Was made an analytic research for the ability to use a rate to measures the probability of the effective demand of health services attributable to smoking. Were used as theoretical methods the comparative and the inductive-deductive. As empiric method was utilized the bibliographic research and the differential calculus. Results: The formula of probability of the effective demand of health services attributable to smoking is growing and concave front of the intensity of the tobacco consumption. Conclusion: The suggested rate to measure the probability of the effective demand of health services attributable to smoking is strong trustable estimating the economic burden attributable to smoking.
Terrorism, population health, and epidemiological dynamics in Nigeria: implications for public health
Authors: BO Ogbonna , BC Mgbemena , LN Ezenekwe , GN Ele , MU Anetoh , Il Ejie , IB Umeh , IJ Nduka , JC Ofomata , AT Nwabanne , UU Epundu , AN Onyeyili , CE Ejim , N Ajagu , AC Ofor
Published: February 2023

Background: Terrorism is the use of violent action in order to achieve political aims or force a government to act. It has become a growing trend in the global scene today in varying dimensions from hijacking, bombing, to state terrorism, bio-terrorism, cyber terrorism, eco-terrorism, nuclear, and narco-terrorism. All these disrupt population health with far reaching consequences. Objective: This study explored the dynamics of terrorism and public health in Nigeria. Methods: A narrative overview of relevant literatures was carried out. Literature search was carried out in PubMed, and Google Scholar. Information from previously published articles covering terrorism and public health was condensed to present a broad perspective and development. Only articles written in English Language carried out between 1999 and 2018 that clearly referred to terrorism, public health and diseases was used. Extracted information was discussed narratively. Results: A total of 1595 people died through terrorist attack in 2013 and 6118 in 2014. Immunization officers were killed in northern Nigeria in 2013. It leading to massive decline in immunization activities in northern Nigeria and contributed to the re-emergence of polio. In 2014, 662 terrorist attacks resulted in the death of 7512 people and 2246 were injured with varying degrees of disabilities. Many internally displaced peoples (IDP) fled to make shift camps with poor hygienic conditions with records of epidemics, psychosomatic conditions, malnutrition, overcrowding, and death. Conclusion: study suggests that terrorism deplete the general living condition of people and predispose them to varying levels of illness and diseases and ultimately disrupting public health status. Review, implementation of government policies, and equitable resource allocation could be utilized as preventive strategies
Patellofemoral (anterior knee) pain syndrome: symptoms, causes and guideline based treatment options
Authors: Madou Karel
Published: February 2023

The Patellofemoral Pain Syndrome (PFPS), also known as Anterior Knee Pain (AKP), is defined as: A complex of pain complaints around the patella (retro-/ peri-patellar), mainly non-traumatic of origin, which leads to a restriction during loaded activities, such as squatting, climbing stairs and cycling.1 Clinicians2 should make the diagnosis of PFPS using the following criteria: The presence of retro-patellar or peri-patellar pain, Reproduction of retro-patellar or peri-patellar pain with squatting, stair climbing, prolonged sitting, or other functional activities loading the Patellofemoral Joint (PFJ) in a flexed position, and Exclusion of all other conditions that may cause anterior knee pain, including tibiofemoral pathologies. Although treatment of patellofemoral pain often begins with simple measures like rest, avoidance or modification of activities that increase the pain, such as climbing stairs, kneeling or squatting or, if needed, over-the-counter pain relievers, most recommended interventions were exercise therapy, foot orthoses, patellar taping, patient education and combined interventions. Not recommended were manual therapy (in isolation), dry needling, patellar bracing, and electrotherapeutic modalities. To evaluate subjective symptoms and functional limitations PROMs (Patient Reported Outcome Measures), such as the KPS/AKPS,3 KOOS-PF4 and VAS/NPRS, are valid and reliable assessments.
Analysis of budget incomes in Romania
Authors: Mihăilescu Adina
Published: February 2023

This study analyzes the importance of work on the one hand and on the other hand, the incomes obtained by the teachers in higher education and the doctors in the field of health. At the same time, we highlight the significant differences that exist between the areas of work supported by the state budget, regarding the obtained income. The workplace is the framework in which a professional activity is carried out and where the following criteria are extremely important: the conditions in which the work is performed, the incomes obtained, the inter-human relations between employees and between employees and management, the possibilities of affirmation and promotion, the duration of the working time, location of work in relation to domicile, content of work. All of these can make work more attractive than another, while also dimensioning, by implication, some elements related to the social importance of the work.
Some socio-community strategies against COVID-19
Authors: Lisboa José Luis Corona
Published: February 2023

Community strength is essential in times of crisis like the one experienced these days with the appearance of COVID-19. This article describes some socio-community strategies to reduce the risk of COVID-19 contagion in human settlements, and thus contribute to the guidelines issued by the various international organizations to combat this pandemic. Some simple and applicable strategies for this particular situation are described.
Wavering between neoliberalism and populism: An empirical analysis of the South American experience, 1990-2015
Authors: Bojanic Antonio N
Published: February 2023

A sample of economic and institutional outcomes in South American nations are analyzed for the 1990-2015 period. Qualitative analysis suggests that populist countries -Argentina, Bolivia, Ecuador, and Venezuela - have fared worse than other American nations in terms of the evolution of basic institutional indicators. Empirical findings on the determinants of political rights and civil liberties and economic growth, however, are more nuanced. While growth and liberties in populist nations seem to be affected differently by some factors, the findings suggest that there are also similarities across all countries, rendering futile making any definitive conclusions. Notwithstanding the difficulty with sweeping assessments, what seems to be true is that most South American nations would experience higher economic growth if they are able to lessen income inequality and decrease corruption levels.
Journalism in the indefinite: A comparative perspective of a soft-retirement activity
Authors: Assala Laurent-Charles Boyomo
Published: February 2023

The international comparative study of journalism as a working activity shows various model of retirement going from a non-interrupted involvement to a complete change. To tight the classical distinction between occupation and profession as Everett Hughes put, the occupational identity goes with the unlimited working activity along the life of a journalist till he dies. While in Cameroon and Africa in general, the model of retirement is similar to the working life, journalists turning out here from resourcefulness to begging, in France to the contrary, a set of changing rules coming from a long process of syndication insure the protection of journalists. If the work of journalists is bound to come to an end in one way or the other, the authors inspired by a perspective based on rudology acknowledged a Three-scale Theory of Retirement (TSR) which accounts for the relationship maintained by sociological theory of retirement of journalists namely the everlasting model of retirement, the alternative oriented model and the liberal model. These models were articulated with each other to reveal the first category of journalists made up of a dominant group of media managers in public media and administrative companies with a guarantee of remuneration and social positions close to that of the other senior civil service and private sector categories. This first category enjoy a comfortable retirement condition The second category at the intermediate level is those of practioners taking the control of their living activity by creating media organs or acquiring them either. They are worked by a militant and even messianic vision of their activity and are involved in trade union dynamics. Their protection after the working life is then guaranteed by the inequal capacity to find another occupation, sometimes very different from journalism but not so far from communication. The last category is that of those who consider the corporate organizations to be detrimental to free competitions among workers. During their period of activity they were used to do many other activities and petit businesses which they will continue till the death. The authors advocate for a better supervision of the retirement of journalists by the state, the professional and the trade union circles.
About the peculiarities of science in Modern Russia
Authors: EP Tavokin
Published: February 2023

Based on statistical data, the processes of the collapse of science in modern Russia are shown: a reduction in the number of scientists, a "brain drain", a decrease in those who want to get into the field of science. The dissonance is revealed, which consists in the fact that the number of representatives of the socio-humanitarian branches of science tends to increase both in absolute and (especially) relative terms. It is shown that this trend is based on a general decline in the quality of scientific research, as a result of which pseudoscientific or pseudoscientific publications prevail in these areas of science. The most important reason for this phenomenon is the removal by the state of the function of the main customer of scientific research. The author suggests restoring this function.