bluuebunny/crossref_metadata_2025 huggingface dataset:
Michele Rago e Romanzi francesi dei secoli XVII e XVIII
Authors: Martinelli Lorella
Published: November 2023

The essay examines the anthology Romanzi francesi dei secoli XVII e XVIII, edited by Michele Rago and published in two volumes by Bompiani in 1951. The text is the result of the collaboration of prestigious writers (such as Bassani, Bonsanti, Luzi, Del Buono) and was conceived for a wide circulation. Even though the anthology’s translation and selection criteria lack scientific and philological rigour, Rago’s operation proves relevant in the way it genetically reconstructs the evolution of French literature from premodern forms of pastoral fable to libertine fiction. It is Laclos’ Liaisons dangereuses (1782), rather than De Sade’s writings, that is identified as the peak of historical and formal maturity: while mirroring reality – society and its conflicts – the novel also accommodates the Enlightenment’s experimentalism and Rousseau’s moral legacy.
Tommaso Landolfi e Narratori russi
Authors: Sulpasso Bianca
Published: November 2023

Tommaso Landolfi’s anthology Narratori russi was published in 1948, but the adventurous creation of the volume began in June 1941. Landolfi started working on the anthology twenty years after the publishing panorama of translated Russian literature had been enriched, thanks to the frenetic dissemination of activities of Slavic studies in the early 1920s in Italy. This article examines both the work of Landolfi in the context of the literature translated from Russian in that period and the “history of anthologies” of Russian literature in Italy. Particular attention is given to the structure and canon of the anthology Landolfi offered to the reader.
Vicia faba SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels
Authors: Lu Jinping , Dreyer Ingo , Dickinson Miles Sasha , Panzer Sabine , Jaślan Dawid , Navarro-Retamal Carlos , Geiger Dietmar , Terpitz Ulrich , Becker Dirk , Stroud Robert M , Marten Irene , Hedrich Rainer
Published: November 2023

To fire action-potential-like electrical signals, the vacuole membrane requires the two-pore channel TPC1, formerly called SV channel. The TPC1/SV channel functions as a depolarization-stimulated, non-selective cation channel that is inhibited by luminal Ca2+. In our search for species-dependent functional TPC1 channel variants with different luminal Ca2+ sensitivity, we found in total three acidic residues present in Ca2+ sensor sites 2 and 3 of the Ca2+-sensitive AtTPC1 channel from Arabidopsis thaliana that were neutral in its Vicia faba ortholog and also in those of many other Fabaceae. When expressed in the Arabidopsis AtTPC1-loss-of-function background, wild-type VfTPC1 was hypersensitive to vacuole depolarization and only weakly sensitive to blocking luminal Ca2+. When AtTPC1 was mutated for these VfTPC1-homologous polymorphic residues, two neutral substitutions in Ca2+ sensor site 3 alone were already sufficient for the Arabidopsis At-VfTPC1 channel mutant to gain VfTPC1-like voltage and luminal Ca2+ sensitivity that together rendered vacuoles hyperexcitable. Thus, natural TPC1 channel variants exist in plant families which may fine-tune vacuole excitability and adapt it to environmental settings of the particular ecological niche.
Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Authors: Bashkirova Elizaveta V. , Klimpert Nell , Monahan Kevin , Campbell Christine E. , Osinski Jason M. , Tan Longzhi , Schieren Ira , Pourmorady Ariel , Stecky Beka , Barnea Gilad , Xie X. Sunnie , Abdus-Saboor Ishmail , Shykind Benjamin , Jones-Marlin Bianca , Gronostajski Richard M. , Fleischmann Alexander , Lomvardas Stavros
Published: November 2023

Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ∼2000 OR alleles in a probabilistic, yet stereotypic fashion. Here, we propose that topographic restrictions in OR expression are established in neuronal progenitors by two opposing forces: polygenic transcription and genomic silencing, both of which are influenced by dorsoventral gradients of transcription factors NFIA, B, and X. Polygenic transcription of OR genes may define spatially constrained OR repertoires, among which one OR allele is selected for singular expression later in development. Heterochromatin assembly and genomic compartmentalization of OR alleles also vary across the axes of the olfactory epithelium and may preferentially eliminate ectopically expressed ORs with more dorsal expression destinations from this “privileged” repertoire. Our experiments identify early transcription as a potential “epigenetic” contributor to future developmental patterning and reveal how two spatially responsive probabilistic processes may act in concert to establish deterministic, precise, and reproducible territories of stochastic gene expression.
Species -Shared and -Unique Gyral Peaks on Human and Macaque Brains
Authors: Zhang Songyao , Zhang Tuo , Cao Guannan , Zhou Jingchao , He Zhibin , Li Xiao , Ren Yudan , Jiang Xi , Guo Lei , Han Junwei , Liu Tianming
Published: November 2023

Cortical folding is an important feature of primate brains that plays a crucial role in various cognitive and behavioral processes. Extensive research has revealed both similarities and differences in folding morphology and brain function among primates including macaque and human. The folding morphology is the basis of brain function, making cross-species studies on folding morphology are important for understanding brain function and species evolution. However, prior studies on cross-species folding morphology mainly focused on partial regions of the cortex instead of the entire brain. Previously, we defined a whole-brain landmark based on folding morphology: the gyral peak. It was found to exist stably across individuals and ages in both human and macaque brains. In this study, we identified shared and unique gyral peaks in human and macaque, and investigated the similarities and differences in the spatial distribution, anatomical morphology, and functional connectivity of them.
Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy
Authors: Liao Zian , Tang Suni , Nozawa Kaori , Shimada Keisuke , Ikawa Masahito , Monsivais Diana , Matzuk Martin
Published: November 2023

Endometrial decidualization, a prerequisite for successful pregnancies, relies on transcriptional reprogramming driven by progesterone receptor (PR) and bone morphogenetic protein (BMP)-SMAD1/SMAD5 signaling pathways. Despite their critical roles in early pregnancy, how these pathways intersect in reprogramming the endometrium into a receptive state remains unclear. To define how SMAD1 and/or SMAD5 integrate BMP signaling in the uterus during early pregnancy, we generated two novel transgenic mouse lines with affinity tags inserted into the endogenous SMAD1 and SMAD5 loci (Smad1HA/HA and Smad5PA/PA). By profiling the genome-wide distribution of SMAD1, SMAD5, and PR in the mouse uterus, we demonstrated the unique and shared roles of SMAD1 and SMAD5 during the window of implantation. We also showed the presence of a conserved SMAD1, SMAD5, and PR genomic binding signature in the uterus during early pregnancy. To functionally characterize the translational aspects of our findings, we demonstrated that SMAD1/5 knockdown in human endometrial stromal cells suppressed expressions of canonical decidual markers (IGFBP1, PRL, FOXO1) and PR-responsive genes (RORB, KLF15). Here, our studies provide novel tools to study BMP signaling pathways and highlight the fundamental roles of SMAD1/5 in mediating both BMP signaling pathways and the transcriptional response to progesterone (P4) during early pregnancy.
Pathos Configuration in the War Crisis Context
Authors: Stoica Gabriela
Published: November 2023

The paper deals, in broad terms, with the discursive functioning of emotions; it proposes a case study: the analysis of the pathemic configuration of the speech delivered by president Zelensky in the joint meeting of the US Congress, on March 16th 2022, within a war crisis context, intrinsically affectively marked. The analysis is set within a rhetorical-argumentative framework, considering the discursive appeal to emotions as a form of “subjective rationality” (Charaudeau 2000), and it aims to highlight the strategic, emotive structuring of the discourse, by means of various intertwining mechanisms of emotional elicitation, with constant reference to the audience’s endoxical profile. As pointed out by the analysis, certain types of (implicit) emotions (sharing a highly active-motivational dimension) are particularly appealed to: basic intensive emotions, such as anger or fear and, especially, sociomoral (both euphoric and dysphoric) emotions, such as pity/compassion, (national) pride, gratitude, admiration, or shame/guilt. Their presence in the speech demarcates a discursive scenario, which supports its main persuasive goal: to obtain the audience’s adhesion to the speaker’s viewpoint, as well as to mobilize a future concrete extra-discursive (re)action.
Contrasting Dimensions behind the Use of Irony and Humour in Times of Crisis
Authors: Alba-Juez Laura
Published: November 2023

In this article the discourse of irony and humor is explored in two sets of memes generated in times of crisis, namely the recent Covid pandemic and the ongoing Russian invasion of Ukraine. Different versions of macro memes are examined in both sets through the lens of the Inferred Contradiction Theory of irony (Alba-Juez 2014). The main research questions were: 1) What type(s) of irony is/are exploited to make the memes humorous? 2)What type of inference is found in the inferred contradiction that is essential for the comprehension of the ironic humor in the memes? 3)   What is the main function of the irony (and humor) in the memes? A qualitative discourse-pragmatic analytic method was used, together with a simple quantitative analysis of the types of irony used. The analysis shows that the humorous irony in the memes is always based in some kind of contradiction that has to be inferred at some discourse-linguistic level, displaying instances of not only propositional but also illocutionary irony, as well as other kinds of irony where the inferred contradiction is found in the subplicit information that is shared by the interlocutors, or even in the images shown. The results reveal that most of the jokes in the memes were sarcastic and thus the inferred contradiction led to the negative evaluation of some person or situation. The irony in the majority of the memes was of the conversational, negative and propositional types, and the functions fulfilled by the ironic humor were found to serve contrasting and contradictory motivations (aggressiveness towards the out-group and affiliation with the in-group), as well as that of amusing the readers.
The effect of polypharmacy on rheumatoid and psoriatic arthritis treatment: retrospective study
Authors: Kara Mete , Alp Gülay , Palanbek Yavaş Seher , Taşdemir Anıl , Ketenci Sertaç , Kara Müge Mercan , Ozduran Erkan
Published: November 2023

Background

Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are chronic, progressive inflammatory diseases that can be accompanied by other diseases. In recent years, with the increase in the lifespan of individuals, the concept of polypharmacy has become more prominent. We aimed to show the prevalence of polypharmacy and the effects of polypharmacy on disease activity in RA and PsA.

Methods

This study included PsA patients who had peripheral joint involvement and, RA patients. Since PsA has a heterogeneous clinical picture, only patients with peripheral joint involvement were included in the study and patients with inflammatory low back pain or radiological sacroiliitis or spondylitis, dactylitis or enthesitis were not included in the study due to homogeneity concerns. The numbers of medications used by the patients at the onset of their treatment and at sixth months into their treatment were recorded. Polypharmacy was accepted as the simultaneous use of at least five medications by the person. The Disease Activity Score 28 joints C-Reactive Protein (DAS-28 CRP) was used to assess disease activity for both disease. The modified Charlson Comorbidity Index (CCI) scores of the patients were calculated based on their chronic diseases.

Results

The sample of the study included 232 RA and 73 PsA patients. Polypharmacy was present at the treatment onset in 115 (49.6%) of the RA patients and 28 (38.4%) of the PsA patients. At the sixth month of treatment, polypharmacy was present in the sixth month of the treatment in 217 (93.5%) RA and 61 (83.6%) PsA patients. The mean ages of the RA and PsA patients who were receiving polypharmacy treatment at the beginning were significantly older than the mean ages of those who were not receiving polypharmacy treatment. In both the RA and PSA groups, the patients with polypharmacy at the beginning had statistically significantly higher DAS-28 CRP scores at six months of treatment than those without polypharmacy at the beginning (p < 0.001).

Conclusion

Polypharmacy was present both at the time of diagnosis and in the treatment process in the RA and PsA patients, and the presence of polypharmacy at the beginning of the treatment was among the factors that affected the treatment of these patients by significantly affecting their 6th-month DAS-28 CRP values.
Spray Characteristics Analysis of Fire Sprinkler Spray with Image Processing
Authors: Bang Saemi , Kim Taehoon
Published: November 2023

Sprinkler systems are effective in suppressing fires during their initial stages. The ability of a sprinkler to suppress a fire is contingent on the density, size, and velocity of the droplets it emits. In this study, a high-speed camera was employed to measure the size and velocity of droplets generated by a sprinkler head with a K-factor of 80. To capture images of the sprinkler spray, two acrylic partitions were placed 3 cm apart, with the sprinkler head positioned in the center. A light source was positioned behind the spray, and images were recorded at a resolution of 1024 × 1024 pixels and a speed of 4000 fps. During the image processing phase, bounding circles were drawn using the mean of the major and minor axes of the droplets, and these circles were used to calculate the diameter, velocity, and momentum of the droplets. It was observed that smaller droplets were predominantly present closer to the sprinkler head, while larger droplets were more prevalent in regions farther away. The larger droplets exhibited higher velocities and momentum. As the vertical distance increased, droplet velocity and momentum also increased, primarily due to the influence of gravity.
Association of Obesity with Vitamin-D Section Deficiency and Anaemia: A Cross-sectional Study
Authors: Bhat S Deepak , Hegde Swati , Srikanth N
Published: November 2023

Introduction: Obesity is a growing health concern, especially in developing countries like India. Overweight and obesity are considered risk factors for numerous diseases, including micronutrient deficiencies. However, there is a lack of data on the association between vitamin-D status and anaemia in obesity. Therefore, this study was conducted in an urban setting where obesity is more prevalent. Aim: To investigate the association between increased Body Mass Index (BMI) and vitamin-D deficiency and anaemia. Materials and Methods: This cross-sectional observational study included 62 healthy overweight or obese adults from Ramaiah Medical College and Hospitals in Bengaluru, South India, from December 2021 to February 2022. Anthropometric measurements were taken, and blood investigations were conducted to estimate vitamin-D levels and haemoglobin levels. Pearson’s chi-square test was used to determine associations between the two groups. Results: The study included (62) healthy adults, of whom 28 subjects (45.1%) were classified as obese (BMI ≥25 kg/m2) and 34 subjects (54.9%) were classified as overweight (BMI 23-24.9 kg/m2). There were 22 males and 40 females, with a mean age of 48.5 years. Vitamin-D deficiency was observed in 50 patients (80.6%). The prevalence of vitamin-D deficiency was higher in the obese group (n=23, 82.1%) compared to the overweight group (n=27, 79.4%), although this difference was not statistically significant. Anaemia was present in 14 patients (22.6%). Overweight males were more likely to be anaemic. Anaemia was observed more frequently in elderly overweight and obese patients and was statistically significant (p-value=0.039). Conclusion: Vitamin-D deficiency and anaemia were seen as common problems in apparently healthy individuals with high BMI. This is a health concern that needs to be addressed, and early screening and appropriate treatment can help improve the quality of life.
Determination of the Impact of Various Commonly Consumed Beverages on the Colour Stability of Universal Nanohybrid, Nanofilled, and Microhybrid Composite Resins: An In-vitro Spectrophotometric Study
Authors: Modi Shreya , Joshi Chintan , Somani Mona , Patel Aashray , Parmar Anisha , Jadawala Kruti
Published: November 2023

Introduction: The challenge in restorative dentistry is related to changes in the colour of composite over time when exposed to a variety of common beverages, which necessitates additional expenses for the patients. Aim: To compare the colour changes of various composites currently available on the market after exposure to commonly consumed beverages. Materials and Methods: This in-vitro study was conducted from May 2022 to December 2022 in the Department of Conservative Dentistry and Endodontics at Karnavati School of Dentistry in Gandhinagar, Gujarat, India. A total of 120 disc-shaped composite pellets, with 40 specimens for each type of composite (nanohybrid, nanofilled, and microhybrid), measuring 6×2 mm, were prepared and divided into four subgroups based on the beverages used (Distilled water, coca-cola, Tea, and Coffee). The samples were submerged in the respective beverages and kept at 37°C for seven days. Colour assessment was performed using a spectrophotometer before and after immersion. The obtained Commission International de l Eclairage (CIE) ΔE values were recorded after measuring the CIE L*a*b* values. Data analysis was conducted using Statistical Package for Social Sciences (SPSS) software version 20.0, utilising a paired t-test, post hoc Tukey’s test, and one-way Analysis of Variance (ANOVA). A significance level of p<0.05 was used. Result: Among all the beverages, the nanofilled composite showed the highest mean colour change, while the nanohybrid composite exhibited the lowest. Overall, the greatest colour change was observed with tea, followed by coffee, coca-cola, and the least with distilled water. In tea, coffee, and cocacola, the nanohybrid composite and nanofilled composite showed a statistically significant difference in mean colour change: 16.74 (p<0.001), -7.29 (p<0.001), and -1.02 (p=0.018), respectively. However, the difference between the nanohybrid and microhybrid composite was statistically insignificant. Conclusion: The nanohybrid composite demonstrated the least mean colour change, followed by the microhybrid composite, while the nanofilled composite exhibited the highest colour change.
Serum Oestrogen and Progesterone Levels in the Early Luteal Phase as Predictors of Successful In-vitro Fertilisation Outcome: A Prospective Cohort Study
Authors: Kapur Aishwarya , Goel Meenakshi , Prasad Sudha
Published: November 2023

Introduction: The serum levels of oestrogen and progesterone in the luteal phase of In-vitro Fertilisation (IVF) cycles using the long agonist protocol may play a role in predicting the outcome of the cycle. Aim: To determine the levels of oestrogen and progesterone in the early luteal phase of IVF cycles and their association with the pregnancy rate. Materials and Methods: A prospective cohort study was conducted in the IVF centre at Maulana Azad Medical College, Delhi, India, from September 2014 to August 2016. A total of 150 women undergoing IVF were recruited over a period of two years and underwent IVF using the standard long agonist protocol. Luteal phase support was provided according to the Institutional protocol. Blood samples were collected on the day of Ovum Pick Up (OPU) (day 0), the day of embryo transfer (day 3), the day of implantation (day 6), and the day of confirmation of biochemical pregnancy (day 17) to estimate serum Estradiol (E2) and Progesterone (P) levels. Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) version 16.0, and a p-value <0.05 was considered significant. Results: The mean age of patients in the study was 31.17±1.09 years, and the mean duration of infertility was 8.2±4.2 years. Serum E2 (day 6, 1403.23±376.67 vs 1258.98±354.31 pg/mL; p=0.02) as well as P4 levels (day 6, 77.82±21.82 vs 68.90±22.17 pg/mL; p=0.01) were significantly higher on the day of implantation and day of confirmation of biochemical pregnancy (day 17, E2 541.80±498.01 vs 289.34±171.94 pg/mL, p<0.001; P4 70.61±121.47 vs 36.17±16.63 pg/mL, p<0.001) among those who conceived compared to those who did not conceive. Conclusion: Serum E2 and P4 levels in the luteal phase may help guide luteal phase support and serve as predictors of a successful cycle outcome in women undergoing IVF using the long agonist protocol.
Chest Physiotherapy as an Adjunct in a Mechanically Ventilated Infant with Atelectasis: A Case Report
Authors: Kumar R Hemanth , Nair Aishwarya
Published: November 2023

Atelectasis occurs due to impaired airway clearance or complete airway obstruction caused by inflammation, leading to the collapse of tiny airways either partially or completely. This results in impaired exchange of carbon dioxide and oxygen. A chest X-ray, Computed Tomography (CT), and/or thoracic ultrasound are helpful in identifying atelectasis. In the present case, a 5-month-old female infant was reported to the Paediatric Department with the chief complaint of seizure and loss of consciousness. An X-ray was performed, revealing complete left lung atelectasis with no air entry. The infant was referred for physiotherapy in addition to medical management. Through seven intensive and regular sessions of respiratory physiotherapy, which included techniques such as percussion, vibration, and postural drainage for more than 30 minutes, there was successful resolution of the consolidation and improvement in presenting symptoms. After the final sessions of physiotherapy, the infant was discharged with physiotherapy home programs. This suggests that physiotherapy is an integral part of paediatric critical care, ensuring a good prognosis and faster recovery.
MANAGEMENT OF SCHIZOPHRENIA WITH SELECTED AYURVEDA PROTOCOL: A CASE REPORT
Authors: Vipin Sharika , M Jithesh , PM Aparna
Published: November 2023

Schizophrenia is a chronic psychiatric illness characterized by disrupted thought perceptions, emotional responsiveness, and social interactions. In Ayurveda, psychiatric illness is dealt with as one of the eight specialties, Bhutavidya. As per the presentation and severity of symptoms, schizophrenia can be categorized under the disease Unmada (Psychotic disorders) explained in Ayurveda psychiatry. Protocols including sodhana (Purification therapy), samana (Pacification therapy), and rasayana (Rejuvenation therapy) are being observed as effective in the management of schizophrenia. A 15-year-old male student presented with increased anger and impulsivity associated with increased use of mobile phones from 7 months. In the last 3 months, he gave with self-talk, self-laugh, and some finger mannerisms. Parents reported reduced self-hygiene, delusions, and auditory and visual hallucinations. The condition was diagnosed as Schizophrenia as per DSM–V criteria. As per Ayurveda, the condition was dealt with as pitta kaphaja Unmada, where the anger and impulsivity were considered as pitta dosha vitiation and decreased self-hygiene, preferred to be sitting alone, as kapha dosha vitiation. The protocol was fixed on the basis of dosha assessment which included shirodhara, snehapana, virechana, vasti, nasya, shiropichu, and samana medicines. Positive and Negative Syndrome Scale (PANSS) for schizophrenia was used for evaluation. The Interventions contributed to improvement in the patient’s symptoms prior to hospital discharge and there was also a significant reduction in the PANSS score.
ROLE OF SAINDHAVADI BIDALAKA IN THE MANAGEMENT OF VATAJA ABHISHYANDA (ALLERGIC CONJUNCTIVITIS)
Authors: Nawle Sonam Vasant , Kotangale Sumedha Yogesh
Published: November 2023

In the present age, Allergic Conjunctivitis is the most common eye disease caused due to allergens like dust, pollen from trees and grass, animal dander, chemical scents, etc. The prevalence of allergic Conjunctivitis in India is on the higher side, affecting 15% to 40% of the Indian population and it is observed to be a seasonal disease, i.e., during summer. According to Acharya Sushruta, Abhishyanda (Conjunctivitis) is the root cause of almost all ocular diseases and, if it is not treated priorly, may land in a chronic course, further resulting in developing severe complications such as Adhimantha (Glaucoma) etc. Vataja Abhishyanda can be correlated to Allergic Conjunctivitis. Allergic Conjunctivitis is characterized by itching, burning sensation, watery, mucous, or stringy discharge, mild photophobia, and eye hyperemia. In the present study, according to Acharya Charaka, Saindhavadi Bidalaka was done on the patient having symptoms of Vataja Abhishyanda (Allergic Conjunctivitis) for 7 days. Vata is said to be the predominant dosha of Vataja Abhishyanda (Allergic Conjunctivitis). Saindhavadi Bidalaka has Vataghna properties (pacify Vata dosha); thus, it will reduce the symptoms of Vataja Abhishyanda (Allergic Conjunctivitis). A total of 3 patients of Vataja Abhishyanda (Allergic Conjunctivitis) were treated by Saindhavadi Bidalaka for seven days. The assessment of the condition was done before and after treatment. The result of the study was analyzed by comparing the before and after the completion of the study. The result proves to be significantly effective based on its clinical assessment.
ABHYANTAR KRIMI (INTESTINAL WORM INFESTATION - PUREESHAJ KRIMI) AND THEIR MANAGEMENT: A REVIEW
Authors: Ahari Sanjay , Rai Dinesh Kumar , Vyas Prem Prakash , Awasthi Nidhi
Published: November 2023

The utility of Ayurveda science is to preserve a healthy individual's health and to treat a patient's ailment. Ayurveda defines health as a balanced condition of dosha, dhatu, agni, mala and a pleasant state of soul, sense organs, and mind. In today's contemporary environment, there is less emphasis placed on health. In the midst of a flurry of labor, lower socioeconomic group members lack basic hygiene, literacy, and the usage of undercooked food or incorrect cleaning of food items, among other things. This is the main reason of Abhyantar Krimi (helminthiasis) in children, which is ignored by both parents and physicians as it is one of the common pediatric problems faced worldwide especially in tropical and subtropical geographical region. Helminthiasis is noticed, when it became severe and cause harm to the children. According to recent worldwide estimates, more than a quarter of the world's population is affected with one or more parasitic illnesses, the most frequent of which is round worm, Ascaris lumbricoides. Ayurveda classics have so many references of helminthiasis named as Krimi roga. Acharyas states 20 type of Krimi classified as Bahya and Abhyantar in which helminthiasis can be correlated with Pureeshaj Krimi. Krimighna (anti helminthic) medicines are available in market, causing side effects like nausea, vomiting, lethargy, etc. Today’s world, Medicinal plants are gaining relevance in the current day due to the different negative effects of modern medication and the less adverse effects of Indian medicinal herbs. Current article presented by the introduction of Pureeshaj Krimi and their management with herbs.
MASANUMASIK GARBHA VIKAS KARMA AND ITS CORRELATION WITH EMBRYOLOGY OF MODERN SCIENCE: A REVIEW
Authors: Singh Neetu
Published: November 2023

Background: The Vedic scriptures say there is an inextricable link between the human and universe. The very elements of human life exist outside in the cosmos as well. The components of the body at the cellular and sub-cellular levels are innumerable due to overabundance, over-minuteness and transcending perception. Developmental anatomy is studied in the " embryology " branch of modern science. Embryology is the study of the embryo/foetus from the moment of its inception up to the time when it is born as an infant. In Indian literature, the history of embryology can be linked to the Vedas, Mahabharata, Buddhist literature, Upanishad Purana, etc. The 'Garbhavkranti understanding of the garbha factor taking part in the formation of garbha has been dealt with mainly based on material available in Ayurveda and other allied resources. Therefore, because of the above, we can say the treatise of Ayurveda formerly validated the evidence of the development of a foetus in modern medical science.Aim and objectives: Comparative review of Masanumasik Garbha vikas karma concepts with special reference to embryology.
A REVIEW ON UPAVASA: THE ANCIENT INDIAN FASTING RITUAL FOR SPIRITUAL AND PHYSICAL WELLBEING
Authors: Jerone Jojan J , MM Aleeshya , Chandran Amal S
Published: November 2023

Ayurveda is the science of life. It offers advice on how to keep healthy people well and how to treat sick people's problems. Fasting is one of the ten langhana (those that promote lightness of the body) therapies and one of the daivavyapashraya (spiritual) therapies in Ayurveda. Ayurveda also claims that fasting stimulates the digestive system and results in the digestion of ama-dosha (metabolic poisons). Upavasa is a means to come closer to the all-powerful from a spiritual and yogic perspective. Fasting stimulates autophagy, according to scientists. In 2016, Yoshinori Ohsumi, a Japanese cell scientist, won the Nobel Prize in Medicine for his studies on autophagy, a process through which cells recycle and regenerate their contents. Numerous research that has been published suggests that fasting has benefits for neuroprotection and ageing.
Pineapple Cultivation in Uttar Pradesh Central Zone: Challenges and Opportunities
Authors: Anushi  , Krishnamoorti  , Shivam  , Chouhan Nitin Kumar , Kumar Avdhesh , Kumar Prabhat , Singh Vivek , Singh Abhishek
Published: November 2023

Pineapple cultivation in the central zone of Uttar Pradesh represents a dynamic agricultural endeavor, characterized by both challenges and opportunities. This abstract explores the unique factors that farmers face in this region, shedding light on the potential for this tropical fruit's growth and economic contribution. The central zone of Uttar Pradesh experiences a diverse climate, ranging from hot summers to cold winters. Pineapple, originally a tropical fruit, demands consistent warmth [1]. This climatic variability presents a significant challenge for pineapple growers, who must adapt their cultivation practices to ensure optimal growth and yields. Moreover, the soil quality in this region often falls short of the sandy loam and fertility requirements that pineapple plants thrive in [2]. Soil testing and enhancement become critical tasks for farmers looking to establish a suitable environment for pineapple cultivation. Pests and diseases further compound the challenges. Pineapple plants are susceptible to a range of issues, including mealybugs, aphids, and the dreaded fusarium wilt. Effective pest and disease management strategies are vital to maintaining healthy crop yields while minimizing the use of chemical pesticides [3]. Additionally, many farmers in the central zone may lack the requisite technical knowledge and skills needed for successful pineapple cultivation. Access to training and extension services, as well as modern farming practices, becomes essential to enhance agricultural techniques and overcome these challenges. On the flip side, there are significant opportunities awaiting pineapple growers in this region [4]. Pineapples are increasingly sought after for their unique flavor and nutritional value, creating a robust market demand in both local and national markets. Farmers have the potential to tap into this growing demand and enhance their income through pineapple cultivation. Furthermore, integrating pineapple cultivation into existing cropping systems offers an avenue for crop diversification, reducing dependency on a single crop and enhancing overall farm sustainability. Value addition through processing, such as converting pineapples into juice, jam, or canned fruit, allows farmers to expand their product range, increase shelf life, and reduce post-harvest losses [5]. Government support in the form of initiatives and subsidies designed to promote horticulture and agricultural diversification provides a crucial opportunity for pineapple growers to access financial and technical assistance.
Comparative Performance Analysis of a Remote-Controlled Paddy Weeder in Varied Soil Conditions
Authors: Veeraprasad G.  , Srininvas I.  , Ramireddy K. V. S.  , Hemakumar H. V.  , Srinivasa Rao V.
Published: November 2023

Aim: Remote controlled paddy intercultural equipment was evaluated under sandy, sandy loam and loamy soils in terms of fuel consumption (l/h), field capacity (ha/h) and field efficiency (%).

Study Design: Field evaluation of robotic paddy weeder.

Place and Duration of Study: Dr NTR College of Agricultural Engineering, Bapatla. Duration of study was from August, 2023 to September, 2023.

Methodology: The performance evaluation of weeder was conducted at rotary weeder rotational speed of 160rpm and weeding depth of 50mm in terms of the observations on fuel consumption, field capacity and field efficiency. Weeding operation was carried on 20th day and 40th day after transplanting. Each field test was conducted over a run length of 50m at constant speed and depth in different soils were recorded for all the parameters and each test was replicated thrice to eliminate experimental bias.

Results & Discussion: The highest fuel consumption was observed as 2.2l/h when weeder was operated in loamy soil on 40 days after transplanting and the lowest was 1.2 l/h when the weeder was operated in sandy soils on 20 days after transplanting. The highest field capacity was observed as 0.098ha/h when weeder was operated in sandy soil on 20 days after transplanting and the lowest was 0.076ha/h when the weeder was operated in loamy soils on 40 days after transplanting. The highest field efficiency was observed as 81.66% when weeder was operated in sandy soil on 20 days after transplanting and the lowest was 63.33% when the weeder was operated in loamy soils on 40 days after transplanting.

Conclusion: The performance of remote operated paddy weeder is best when operated on 20 days after transplanting when compared with 40 days after transplanting for increasing the productivity.
A Comprehensive Review on Protected Cultivation of Horticultural Crops: Present Status and Future Prospects
Authors: Jain Shubham , Kore Deepak S. , Kishorkumar G. K.  , Mohapatra Amrita , Baksh Hari , Kumar Vipin , Mohanty Sukirti , Haokip Songthat William
Published: November 2023

Protected cultivation of horticultural crops has emerged as a crucial technique in modern agriculture, offering numerous benefits such as increased yield, enhanced quality, and protection against adverse climatic conditions and pests. This comprehensive review aims to present the current status of protected cultivation practices and explore its future prospects in horticulture. The review begins by discussing the various types of protected cultivation structures, including greenhouses, high tunnels, and shade houses, along with their advantages and limitations. It then highlights the significance of protected cultivation in addressing global food security challenges by ensuring year-round crop production and reducing dependence on seasonal variations. The review further explores the impact of protected cultivation techniques on the growth and development of horticultural crops, including improved crop morphogenesis, precipitation management, and the optimization of environmental factors such as temperature, humidity, and carbon dioxide levels. Furthermore, the utilization of advanced technologies like hydroponics, aeroponics, and vertical farming within protected cultivation systems is examined, with an emphasis on their potential for maximizing crop productivity while minimizing resource consumption. Moreover, the paper delves into the challenges and constraints faced in implementing protected cultivation, including cost considerations, energy requirements, and the use of synthetic inputs. It discusses sustainable and environmentally friendly approaches, such as utilizing renewable energy sources and adopting organic farming practices, to mitigate these challenges and promote ecological balance. Lastly, the review discusses some future prospects and trends in protected cultivation, including the integration of precision agriculture techniques, the use of artificial intelligence, and the adoption of smart farming technologies. These advancements have the potential to further optimize resource utilization, improve automation, and enhance crop monitoring and management, ultimately leading to greater yield and quality improvements in horticultural crop production.
Cervical Cancer Screening in Women With Physical Disabilities
Authors: Vinson Alexandra H. , Norrid Corrianne , Haro Elizabeth K. , Ernst Susan , El Khoury Christelle , Alves Martha L. , Kieber-Emmons Autumn , Kamath Mulki Ashwini , Butcher Emma A. , Kalpakjian Claire , McKee Michael M. , Harper Diane M.
Published: January 2025

Importance

Cervical cancer screening is a crucial public health intervention, but screening disparities exist for women with physical disabilities (WWPD).

Objective

To explore the experiences of WWPD with both traditional speculum examination–based screening and at-home self-sampling for cervical cancer screening.

Design, Setting, and Participants

This qualitative study enrolled 56 WWPD to test self-sampling kits, provide feedback via a survey, and participate in a qualitative interview. An interprofessional team conducted semistructured interviews with 16 key informants and 40 pilot participants for 56 WWPD from November 1, 2021, through April 30, 2023. All completed a self-administered quantitative survey. Key informants’ experiences with 4 self-sampling devices helped determine which 2 self-sampling kits would be offered to participants in a pilot study.

Main Outcomes and Measures

A coding scheme was developed to represent inductive codes generated through preliminary coding and deductive codes representing domains from the Theoretical Domains Framework. This coding scheme was used to conduct a 2-pass thematic analysis.

Results

Of the 56 WWPD (mean [SD] age, 45.4 [9.1] years) who participated in the study, 28 (50.0%) were up to date with cervical cancer screening. Participants described accessibility barriers and clinician ableism that made speculum-based in-office examinations difficult, leading some participants to delay or avoid screening. In contrast, participants described self-screening as more comfortable and convenient, regardless of whether they prefer future speculum-based screening. Their responses also allowed for the exploration of how screening preferences may impact future screening behavior.

Conclusions and Relevance

Interviews with WWPD suggested that access to self-sampling screening options would be more comfortable for cervical cancer screening participation. Understanding participants’ experiences with self-sampling devices generates insights into improving screening experiences for WWPD.
Clinical Presentation and Course of Pulmonary Involvement in Chronic Nonbacterial Osteomyelitis
Authors: Hospach Toni , Blankenburg Friederike , Heinkele Anita , Rücklová Kristina , Müller‐Abt Peter , Weller‐Heinemann Frank , Buchtala Laura , Maier Jan , Kümmerle‐Deschner Jasmin , Reiser Christiane , Janda Ales , Urban Andreas , Berendes Reiner , Skrabl‐Baumgartner Andrea , Brunner Jürgen , Trauzeddel Ralf , Haas Johannes Peter , Holl‐Wieden Annette , Morbach Henner , Schnabel Anja , Brück Normi , Hahn Gabriele , Emminger Wolfgang , Valent Isabella , Borchers Regine , Klemann Christian , Tsiflikas Ilias , Klotsche Jens , Minden Kirsten , Hedrich Christian M. , von Kalle Thekla
Published: January 2025

Objective

Pulmonary involvement in chronic nonbacterial osteomyelitis (CNO) is rare. Limited awareness results in diagnostic challenges, especially because malignancy or infection needs to be considered.

Methods

Based on a survey shared among centers participating in the Kerndokumentation Deutsches Rheumaforschungszentrum (Germany), this study investigated clinical and imaging presentations, demographic features, treatment response and outcomes of pulmonary involvement in CNO (pCNO). Magnetic resonance imaging and computed tomography images were read centrally by an experienced pediatric radiologist.

Results

Twenty‐two patients with pCNO were included in this study. Among patients with CNO, pulmonary involvement was more common in girls (91% vs 62.8%, P = 0.006) and patients with multifocal bone lesions (95% vs 65%, P <0.001) but was not associated with systemic inflammation or additional organ involvement. Forty‐two pulmonary lesions were counted with a median of two per patient (two to six). They displayed a median size of 1.8 cm (0.3–4.0 cm) and followed mono‐ (40%) and oligo‐focal (60%) patterns representing consolidations or nodules, abutting the pleura in 50%. Although prominent hilar lymph nodes were present (in 19% of patients), no pathologic enlargement (>1 cm) was seen. When available (3 of 22 patients), histology revealed granulomatous inflammation with lymphocyte infiltration. Development and courses of pCNO did not associate with treatments chosen. Complete remission was reported in 60% of patients, partial remission in 20%.

Conclusion

pCNO is usually asymptomatic. Although more common in girls and patients with multifocal CNO, pCNO is not associated with systemic parameters of inflammation or specific organ involvement. Prognosis of pCNO is favorable, and most lesions resolve over time. Thus, a careful watch‐and‐wait strategy may be appropriate.
Non‐Enzymatic Destruction of the Extracellular Matrix for Activatable Orthotopic Tumor Treatment and Enhanced Drug Penetration
Authors: Wang Hui , Feng Ruxin , Wang Yan , Ma Qian , Yuan Di , Yang Xi , Xu Suying , James Tony D. , Wang Leyu
Published: January 2025

The controlled release and enhanced penetration of drugs to deep‐seated tumors is highly desirable but faces many challenges. Herein, supramolecular biomimetic nanoaggregates (HFCu NAs) are constructed with fluorinated histidine and copper ions via multivalent interactions (metal coordination and aromatic packing), affording tumor microenvironment responsive “turn‐on” 19F magnetic resonance imaging （19F MRI） guided drug delivery and specific tumor therapy. By virtue of ligand engineering and pH‐triggered conformation changes, HFCu NAs exhibit enhanced reactive oxygen species （ROS）generation due to lower pH levels at tumor sites, leading to the stepwise collapse of the extracellular matrix (ECM), which is analogous to targeted protein degradation, without requiring endogenous enzymes. Consequently, the breakdown of the ECM provides positive feedback for the permeation of HFCu NAs, thereby, significantly inhibiting orthotopic tumor growth with explicit immunogenic cell death. As such, the proposed platform exhibits significant potential as activatable drug delivery vehicles for enhanced drug permeation and therapy.
Asymmetric Structural Design for Absorption‐Dominated Electromagnetic Interference Shielding Composites
Authors: Zhou Meng , Yu Zan , Yan Qiming , Zhang Xinya
Published: January 2025

Excessive electromagnetic pollution caused by electromagnetic waves can interfere with the normal use of electronic devices or cause unnecessary damage to human health. Although conductive polymer composites (CPCs) are used to replace traditional metals as an effective strategy for managing undesirable electromagnetic waves, CPCs have a non‐negligible trade‐off in the enhancement of electromagnetic interference (EMI) shielding effectiveness and absorption coefficient because of their reflection‐dominated EMI shielding mechanism. Therefore, to alleviate secondary electromagnetic pollution, absorption‐dominated EMI shielding composites with asymmetric structures are urgently needed. Recently, asymmetric structural designs for absorption‐dominated EMI shielding composites have advanced significantly, but have seldom been summarized and discussed in detail. Consequently, this review first systematically summarizes the current progress of absorption‐dominated EMI shielding composites with asymmetric structures after a brief clarification about the necessity and configuration of asymmetric structure design. Afterward, various absorption‐dominated EMI shielding composites with asymmetric fiber, layered, porous, composite structures are systematically described. Besides, the versatility of absorption‐dominated EMI shielding composites with asymmetric structures is briefly introduced. Finally, the current challenges and prospects are proposed to guide future advancement in the EMI shielding field.
A Super‐Chlorophobic Yet Weak‐Reconstructed Electrocatalyst by Fluorination Engineering toward Chlorine Oxidation‐Free and High‐Stability Seawater Electrolysis
Authors: Mu Jiawei , Yu Chang , Song Xuedan , Chen Lin , Zhao Jiarui , Qiu Jieshan
Published: January 2025

Direct seawater electrolysis is key for achieving sustainable green‐hydrogen production and transitioning toward a decarbonized energy system. However, its performance is limited by significant challenges, mainly catalyst instability, which is caused by excessive reconstruction, low catalytic activity, and aggressive chlorine‐corrosion. Herein, high‐electronegativity F is introduced into NiFe layered double‐hydroxide (F‐NiFe‐LDH) through fluorination engineering to induce electron‐deficient regions around Ni, thus creating abundant intrinsic high‐valence Ni sites. Correspondingly, the features of weak reconstruction accompanied by high stability, chlorophobic surface, and high‐activity lattice oxygen are produced on the F‐NiFe‐LDH, confirmed detailedly by experiment and theory. Consequently, the F‐NiFe‐LDH exhibits a superior oxygen evolution reaction (OER) activity with low overpotentials of 306 and 375 mV to reach 500 mA cm−2 at alkaline simulated seawater and alkaline seawater, respectively. Also, it demonstrates a chlorine‐corrosion resistance, along with ultra‐stability seawater electrolysis for over 1000 h at 1000 mA cm−2 without performance degradation, structural collapse, or chlorine oxidation reaction. Furthermore, an anion exchange membrane electrolyzer assembled by the F‐NiFe‐LDH anode shows an energy consumption of only 4.87 kWh Nm−3 for hydrogen production. This work provides an inspiration for designing corrosion‐resistance electrocatalysts aimed at chlorine oxidation‐free seawater electrolysis, which simultaneously achieve high stability and OER activity.