bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility of establishing an integrated railway-based containerised cargo transport network between the Port of Colombo and free trade zones in Sri Lanka
Authors: Rathnayake P. G. B. P. S. , Kavirathna C. A.
Published: September 2023

A large percentage of Sri Lanka's exports and imports are generated by the manufacturing sector and originates from facilities dispersed throughout Export Processing Zones (EPZs) around the country. An efficient hinterland transport network is required between the Port of Colombo and these EPZs. However, road trucks are used as the dominant transport mode for moving containerised cargo to/from Colombo Port. This study proposes a dry port-based containerised import/export cargo transportation method using a railway network to connect the Port of Colombo and the EPZs under several alternative network configurations. This study conducts a questionnaire survey with 40 experts to identify issues with the current road-based container transport network and ascertain the benefits of proposed railway-based networks in Sri Lanka. A majority of respondents highlight the benefits of the proposed network from multiple perspectives along with several drawbacks with the current road-based network. Initially, the feasibility of two alternative dry port locations in Orugodawatta and Kerawalapitiya are analysed. A mathematical model is developed to analyse the feasibility of the proposed alternative networks. Finally, the optimum dry port location is selected as Aluthwaththa using a simulation-based Greenfield analysis approach. Results highlight the advantages of proposed networks under several scenarios. The study demonstrates a systematic approach to decision-making by optimising the local cargo handling process, where, Sri Lankan inland logistic operations will become more efficient, with total transport costs, environmental pollution, and transportation time decreasing significantly.
Development of composite biscuits incorporated with pineapple (Ananas comosus) peel powder and evaluation of their quality characters
Authors: Naseeha N. F. , Pushparaja V. , Vasantharuba S.
Published: September 2023

Pineapple peel is packed with essential nutrients, antioxidants and other healthy compounds; however, their popularity and empirical evidence related to health benefits are limited. Therefore, this study is designed to formulate pineapple peel powder incorporated composite biscuits and evaluate their quality characteristics. Initially, pineapple peel powder was prepared and its functional, chemical and nutritional evaluation were analyzed. Then biscuits were formulated by various ratios of pineapple peel powder (0%, 5%, 7%, 10% and 12%) and organoleptic evaluation was conducted. Based on the findings from sensory evaluation studies 7% and 10% pineapple peel powder incorporated biscuits were selected for further studies: physical, chemical and nutritional evaluation, along with control. According to the findings, biscuits formulated with pineapple peel powder had better antioxidant properties and higher crude fiber, ash, sugar, potassium and ascorbic acid contents than control biscuits. Moreover, 10% peel powder incorporated biscuit was selected as the best blend ratio using results obtained by nutritional and sensory analysis. Additionally, storage studies showed that these biscuits can be stored for 60 days without microbial spoilage. The present study recommended pineapple peel powder enriched biscuits may be a better alternative product based on the results.
Clinical and epidemiological features of pelvic fractures presenting to the emergency department in a tertiary health care hospital in south India: A retrospective study
Authors: Guguloth Ramesh Babu , Srilatha Yagadi
Published: September 2023

Objective:

To determine the clinical and epidemiological features of pelvic fracture patients presenting to the Emergency Department.

Methods:

This prospective observational study was conducted in a tertiary care center in south India. Causes of injury, types of pelvic fractures, the associated injuries, and outcome at the time of discharge were recorded.

Results:

A total of 140 patients were included in this study. Most patients were classified as type A (n=62), followed by type B (n=48) and type C (n=30). A total of 112 patients were injured due to road traffic accidents, followed by a fall from a height (n=23) and a fall from a heavy object (n=5). Most subjects had facial injuries (n=99, 70.7%), followed by head injuries (n=51, 36.4%). Five percent of the patients were expired, 12% left against medical advice, and 83% were discharged.

Conclusions:

The incidence of pelvic fractures presenting to the Emergency Department is relatively high in India. Road traffic accidents are the primary cause of pelvic fractures and associated facial and head injuries. The outcomes demonstrate the need for improved prevention strategies and comprehensive management protocols to reduce mortality.
Central venous catheterization-related complications in a cohort of 100 hospitalized patients: An observational study
Authors: Singh Reena , Patel Naimish , Mehta Nidhi , Singh Gaurav , Patel Nirav
Published: September 2023

Objective:

To evaluate the complications of central venous catheterization (CVC).

Methods:

A prospective, observational study was conducted at a tertiary care center in India from December 2018 to September 2020. Critically ill patients (aged ≥18 years) in the intensive care unit undergoing CVC procedures were included in the study. Baseline demographics and detailed medical history were recorded. Chest X-rays and electrocardiography were performed on all the patients. Complications associated with CVC were recorded.

Results:

A total of 100 patients with the indication for centralvenous catheter insertion were included. The majority (81%) of the patients were inserted with CVC at the right internal jugular vein. Complications such as arterial puncture (2%), hematoma (4%), blood clot formation (4%), catheter kinking (3%), thoracic injury(1%), thrombophlebitis (6%), sepsis (9%) and nerve injury (1%)were reported.

Conclusions:

Though central venous access is preferred in management of critically ill patients, it has its risks. However, early recognition and prompt management of complications may reduce mortality and morbidity. Physicians and intensive care unit intensivists should be vigilant for central venous catheter-related complications. Suitable site selection, operator experience, and proper catheter maintenance are associated with optimal outcomes.
microRNAs Regulate Survivin in Colorectal Cancer Patients
Authors: Chavoshi Hadi , Bornehdeli Soghra , Asadi Milad , Dolatkhah Roya , Caner Ayse , Raeisi Mortaza
Published: September 2023

Background:

Impaired levels of surviving are associate with increased survival of tumor cells. In this study, we intended to profile the microRNAs (miRNAs) targeting survivin in the tumoral and marginal tissues obtained from Iranian patients with colorectal cancer (CRC).

Materials and Methods:

Fifty CRC patients of Iranian Azari ethnicity were recruited. The RNA content of the tumoral and marginal tissues was isolated and the transcript levels of miR-34a, miR-16, miR-150, and miR-203a and survivin were determined through quantitative Real-time PCR.

Results:

The mRNA expression of survivin was significantly increased (fold change = 3.21, P = 0.0029) in the tumoral tissues in comparison to the marginal tissues. There was significant downregulation of miR-16 (fold change = 0.28, P = 0.003) and miR-203a (fold change = 0.36, P = 0.014) in the tumoral samples in comparison to marginal samples. There was an inverse significant correlation (rho = -0.81; P < 0.001) between the expression of miR-203a and mRNA expression of survivin in the tumoral tissues of CRC patients. The mRNA expression of survivin was higher significantly in the tumoral tissues of CRC patients with lymph node metastasis in comparison to those without lymph node metastasis (P = 0.020). In addition, there was a significantly higher miR-203 expression level in the tumoral tissues of CRC patients with lymph node metastasis in comparison to those without lymph node metastasis (P = 0.011).

Conclusion:

It is suggested that miR-203 plays an oncogenic role in CRC cancer by regulating survivin and lymph node metastasis.
Evaluation of Using Panoramic Radiography and Ultrasonography for Diagnosing Carotid Artery Calcifications
Authors: Mehdizadeh Mojdeh , Shahbazi Shiva , Taheri Hossein , Eslami Azar
Published: September 2023

Background:

The aim of this study was to determine the reliability of panoramic radiograph (PR) as a screening tool for the detection of calcified carotid atheroma (CCA) in comparison with Doppler ultrasonography (DU) examination.

Materials and Methods:

In this study, DU was performed for 52 patients who had carotid calcification or other differential diagnoses of carotid calcification on PR routine screening. The data relating to the presence or absence of calcified atheroma in DU and PR were evaluated using SPSS software.

Results:

In the 52 stated patients, CCA of 9 (18%) patients was diagnosed in the PR. Significant differences in CCA between the two sexes were not found. Also, considerable differences between the left and right sides (P = 0/906) were not found. Moreover, the positive cases who are diagnosed using ultrasonography and PR were 2.25% and 6.5%, respectively.

Conclusion:

PR method is not a good choice for the primary diagnosis method for the carotid artery calcifications due to its less positive diagnosing ratio compared to DU.
Cerebral Venous Sinus Thrombosis Associated Subdural Hematoma: A Case Series on Clinical Presentation and Management
Authors: Chakkera Priyanka , Gupta Manisha , Marasakatla Sandeep , Ramakrishnan Subasree , Kulkarni Girish Baburao
Published: September 2023

Diagnosis and treatment of cerebral venous sinus thrombosis (CVT) associated with subdural hematoma (SDH) is challenging with an increased risk of rebleeding on using anticoagulation. There are no guidelines at present due to its rare presentation. In this report we describe three patients who presented with non-traumatic SDH and CVT over the last 3 years. Clinical assessment, investigations including neuroimaging, and management were reviewed both at time of admission and follow-up. These patients presented with varied CVT syndromes -isolated raised intracranial pressure (ICP), focal and diffuse encephalopathy. Neuroimaging helped in diagnosing CVT and SDH. Cases 1 and 3 had SDH alone, while case 2 had SDH along with intraparenchymal hemorrhage. Management of these patients was tailored individually as per mechanism of CVT. Case 1 was clinically stable, however, she had rebleeding after starting anticoagulation, requiring its discontinuation. Cases 2 and 3 underwent immediate neurosurgical intervention in view of deteriorated sensorium. Although CVT manifesting as SDH is rare, clinicians should have a high index of suspicion to accurately diagnose and manage these challenging cases. The decision regarding use of anticoagulation and apt time for neurosurgical intervention needs to be individualized depending on patients condition and response to treatment.
Clinical and Genetic Analysis of A Father-Son Duo with Monomelic Amyotrophy: Case Report
Authors: Khurana Shiffali , Vats Abhishek , Gourie-Devi Mandaville , Sharma Ankkita , Verma Sagar , Faruq Mohammed , Dhawan Uma , Taneja Vibha
Published: September 2023

Monomelic Amyotrophy (MMA) is a rare neurological disorder restricted to one upper limb, predominantly affecting young males with an unknown aetiopathogenesis. We report a familial case of father-son duo affected by MMA. Whole exome sequencing identified genetic variations in SLIT1,
RYR3 and ARPP21 involved in axon guidance, calcium homeostasis and regulation of calmodulin signaling respectively. This is the first attempt to define genetic modifiers associated with MMA from India and advocates to extend genetic screening to a larger cohort. Deciphering the functional consequences of variations in these genes will be crucial for unravelling the pathogenesis of MMA.
Promoting Global Adult Tobacco Control in South-East Asian Region: Nine-year Retrospective Analysis using World Health Organization MPOWER
Authors: Ashraf Asifa , Menon Ipseeta , Gupta Ritu , Sharma Anubhav , Das Dipshikha , Ahsan Iram
Published: September 2023

It is noted that fire without smoke smokeless tobacco is one of the major scourges in the South-east Asia subcontinent, particularly India. It not only includes adult men and women users but a sizeable chunk entails Indian teenagers. What is worrying though, the models attempting to capture the global usage does not really has much to offer due to paucity of global data. That said, World Health Organization (WHO) has been at the forefront foreshadowing trends and using myriad policy initiatives to help developing countries combat the malaise. Mpower is one such policy framework by the WHO to help countries implement and manage tobacco control, the success of this country-tailored demand reduction interventionist program has lifted a country like Turkey from being one of the highest puffers to drastically reducing its tobacco usage and free smoking indoors by 100%. MPOWER has shown a stellar performance in averting 7.4 million deaths, 30 countries with more than 1 billion people have best pictorially represented health warnings and labels, smoke-free laws and appropriate taxation rules to curb the menace.

Aim:

In light of aforementioned, the aim of this study was to perform the quantitative analysis of WHO report on tobacco control and to get an insight to what extend the program has been successful and the best practices that could potentially be replicated.

Methodology:

The MPOWER composite score was built by employing 6 MPOWER scores using the validated checklist outlined by Iranian and international tobacco control specialists in their study on tobacco control. The independent scores and cutoffs thereof were set in consonance with the key sections of the MPOWER 2011 report.

Results:

MPOWER composite scores that measured policy implementation were then linked to cigarette smoking prevalence and consumption data. An encouraging trend was observed, for example, the highest scores were observable in 2019 and there was noticeable increase in scores of adult daily smoking prevalence (<15 years), cessation programs, and in health warning on cigarette packages. Laws are toothless without adequate intervention at ground level and it was patently clear from monitoring of prevalence data, for example, there was abysmally poor compliance rate, especially with respect to advertisements and other smoke –free policies. The results were mixed at best.

Conclusion:

The dozen countries present themselves as the best replica in the implementation and enforcement of tobacco control program; however, little tweaks here and there to tailor it in accordance with socio-cultural aspects of countries are warranted.
Does Tooth Brushing Prevent Dental Caries among Children? A Systematic Review and Meta-analysis
Authors: Sudan Supinder , Ravishankar T.L , Tirth Amit , Tafadar M. D. Nazamuddin
Published: September 2023

Introduction:

Dental caries is the most widespread noncommunicable disease, which needs immediate attention. Globally, it has been estimated that around 60%–90% of school children are affected with dental caries. These carious teeth can be prevented by simple, cost-effective interventions at the individual and community levels. Various studies reported the role of oral hygiene practices particularly the frequency of brushing of teeth in improving oral health status with varying success. Hence, this meta-analysis was undertaken to determine the effect of oral hygiene practices particularly the frequency of brushing in preventing dental caries in children.

Methods:

The PubMed, Cochrane, Google Scholar, and Scopus databases were searched from January 1, 2000 to October 31, 2022. Hand-searching was performed for relevant journals. Reference articles including children from 3 to 5 years old were retrieved and exported to Mendeley Desktop 1.13.3 software. The risk of bias was assessed using the Newcastle–Ottawa scale for cross-sectional studies. Articles were further analyzed using Open Meta-Analyst.

Results:

The studies included in qualitative synthesis were 27 and 7 were included in meta-analysis. The pooled prevalence of dental caries among children who brushed once a day and twice a day was 48.7% and 36.6%, respectively. The odds of having dental caries in children who brushed their teeth oncea day was found 1.58 times higher than in those who brushed their teeth twice a day. The absolute reduction in dental caries was 11.3% among those who brushed their teeth twice a day than those who did it once a day (95% confidence interval: 3.2%–19.5%, I
2 = 79.59%, P < 0.001).

Conclusion:

Brushing twice a day after 3 years of birth can lead to the prevention of dental caries at the individual and community level. Hence, tooth brushing twice a day can act as major preventive program and one should teach the children when they are young and provided supervised tooth brushing to prevent dental caries.
Body Dysmorphic Disorder in Patients with Cosmetic Concern Attending Dermatology Clinics: A Study of Prevalence, Demographic Correlates, and Psychiatric Comorbidity
Authors: Modi Vidhi , Oswal Rajat M. , Mehta Sonali , Thorat Kosha
Published: September 2023

Objectives:

In this study, we intended to screen the patients who were attending dermatology clinics with cosmetic concerns for body dysmorphic disorder (BDD) to determine the prevalence of BDD and psychiatric comorbidity in patients suffering from BDD, as well as to study the association of BDD with various sociodemographic factors.

Methods:

We did a cross-sectional study at the dermatology clinic of a tertiary care government hospital in Vadodara. We screened 2,500 patients with BDD Questionnaire-Dermatology version (BDDQ-DV). Those screened-positive patients with BDD were diagnosed using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Psychiatric comorbidity was screened using General Health Questionnaire-28 and diagnosed using DSM-5.

Results:

Out of 2,500 patients, 315 screened positive for BDD using the BDDQ-DV scale. Totally, 42 (13.3%) were diagnosed with BDD. BDD was found more in adolescents younger, unemployed, females, with a family history of psychiatric illness and in the urban population. Among 42 BDD patients, 23 had generalized anxiety disorder, 15 had major depressive disorder, and 7 had combined features of both. Among BDD patients, we found that significantly more younger patients had general anxiety disorder (p < 0.05) and significantly more older patients had major depressive disorder (p < 0.05).

Conclusion:

The prevalence of BDD was 13.3%. Among BDD patients, psychiatric comorbidities were also observed. Dermatologists and mental health professionals should work together to prompt diagnosis and timely referral to a psychiatric facility for proper management and evaluation of psychiatric comorbidities.
Ciril Jeruzalemski: Peta krstna kateheza
Authors: Ciril Jeruzalemski  , Bevc Benjamin
Published: September 2023

Prevod sledi edini obstoječi kritični izdaji, ki sta jo objavila W.K. Reischl in J. Rupp, Cyrilli Hierosolymorum archiepiscopi opera quae supersunt omnia, 2 zv. (München 1848, 1860). Cirilove kateheze bodo letos izšle pri založbi Logos.
Distinctive magnetic resonance imaging features in primary central nervous system lymphoma: A case report
Authors: Liu Li-Hong , Zhang Han-Wen , Zhang Hong-Bo , Liu Xiao-Lei , Deng Hua-Zhen , Lin Fan , Huang Biao
Published: September 2023

Among five types of pulmonary hypertension, chronic thromboembolic pulmonary hypertension (CTEPH) is the only curable form, but prompt and accurate diagnosis can be challenging. Computed tomography and nuclear medicine-based techniques are standard imaging modalities to non-invasively diagnose CTEPH, however these are limited by radiation exposure, subjective qualitative bias, and lack of cardiac functional assessment. This review aims to assess the methodology, diagnostic accuracy of pulmonary perfusion imaging in the current literature and discuss its advantages, limitations and future research scope.
Rozwój badań nad komunikowaniem politycznym w Polsce w kontekście światowym
Authors: Dobek-Ostrowska Bogusława
Published: September 2023

Komunikowanie polityczne to proces wymiany komunikatów politycznych między aktorami politycznymi a obywatelami za pomocą dostępnych kanałów komunikowania. Pierwsze badania naukowe pojawiały się przez II wojną światową w krajach anglosaskich, a rozwój nastąpił pod koniec lat 60. Kluczowymi tematami są aktorzy polityczni i ich działania (kampanie wyborcze, polityczny marketing, public relations, reklama), wyborcy, media masowe i społecznościowe. W Polsce badania rozpoczęto w latach 90. na uczelniach głównie w Katowicach, Krakowie, Lublinie, Poznaniu, Warszawie i we Wrocławiu. Development of Research on Political Communication in Poland in a Global Context: Political communication is the process of exchanging political messages between political actors and citizens thanks to the available communication channels. The first scientific research appeared before World War II in Anglo‑Saxon countries. The development took place in the late 1960s. The leading topics are: political actors and their activities (election campaigns, political marketing, public relations, advertising), voters, mass and social media. The research dedicated to political communication in Poland began in the 1990s at the universities, mainly in Katowice, Krakow, Lublin, Poznan, Warsaw and Wroclaw.
Tradycja i teraźniejszość – Krakowskie środowisko badaczy komunikacji politycznej związanych z Instytutem Dziennikarstwa, Mediów i Komunikacji Społecznej Uniwersytetu Jagiellońskiego
Authors: Hess Agnieszka , Szymańska Agnieszka
Published: September 2023

Celem artykułu jest analiza dorobku krakowskich badaczy związanych z Instytutem Dziennikarstwa, Mediów i Komunikacji Społecznej Uniwersytetu Jagiellońskiego z perspektywy historii rozwoju badań nad komunikacją polityczną w Polsce. Autorki prezentują tradycje badawcze wywodzące się ze spuścizny Ośrodka Badań Prasoznawczych i dyskusji naukowych publikowanych na łamach Zeszytów Prasoznawczych, wskazują kluczowych autorów, których prace przyczyniły się do poszerzenia obszaru i perspektywy badawczej komunikacji politycznej jako subdyscypliny nauki o komunikowaniu, oraz mapują na podstawie przeglądu literatury spektrum aktualnych zainteresowań naukowych badaczy związanych z IDMiKS UJ w obszarze studiów nad komunikacją polityczną oraz stosowaną przez nich metodologię.

Tradition and the Present Krakow Community of Political Communication Researchers Associated with IDMIKS JU: The aim of the article is to analyze the achievements of Krakow researchers associated with the Institute of Journalism, Media and Social Communication of the Jagiellonian University from the historical perspective of the development of research on political communication in Poland. The authors present research traditions derived from the legacy of the Press Research Center and scientific discussions published in Zeszyty Prasoznawcze, indicate key authors whose works have contributed to expanding the field and research perspective of political communication as a sub-discipline of communication science and map the current spectrum of their interests and methodology used by them based on the literature review.
MODERN İNSANIN VAHŞİLİĞİNİN ARİSTOTELES’İN ERDEM KURAMI BAĞLAMINDA AŞILMASI ÜZERİNE
Authors: PEHLİVAN Meriç
Published: September 2023

İnsan, hem dinsel hem de bilimsel kodlamalar ışığında en yüksek varlık olarak kabul edilir. İnsanın ürettikleriyle ve kurduğu sistemli medeniyetle kendini ispat ettiği düşünülmektedir. Ancak dünyanın geldiği son nokta göz önünde bulundurulduğunda, bu iddialara şüpheyle yaklaşmak gerektiğinin vurgulanma zorunluluğu ağır bir yük gibi sırtımıza biniyor. Çünkü büyük bir teveccühle bahsedilen insan türünün, yine büyük bir şaşkınlıkla karşılanan “vahşi” bir yaşamın baş aktörü olma özelliği de açıkça devam etmektedir. Yüzyıllar önce büyük filozof Aristoteles tarafından erdem ve mutluluk reçetesi hazırlanmış olan insanın, hala bu rehberliği anlayamamış olması, dünya adına oldukça üzüntü vericidir. Bu çalışma, Aristoteles’in erdem kuramını aktarma ve akabinde modern insanın bu kuram çerçevesinde davranış değişikliğine gitmesi gerektiğinin altını çizme misyonuyla yeni bir yol açma gayesi taşımaktadır.
Zonas de intervenciones críticas en Green Mansions (1904) de William Henry Hudson
Authors: Altamiranda Daniel
Published: September 2023

En ocasión del centenario del escritor argentino-británico W. H. Hudson (1841-1922), me detendré en revisar los múltiples ámbitos o zonas en los que un texto literario particular, que logró alcanzar el privilegio de haber sido de los más difundidos internacionalmente de su producción, Green Mansions, fue intervenido por la industria y por la comunidad interpretativa. Entre las intervenciones que se dieron al texto base, podemos distinguir las traducciones, las adaptaciones y la producción de un guion cinematográfico y la consecuente producción filmográfica. Entre los textos críticos, pueden recuperarse varias dimensiones: la histórica, que trata al texto como representante del romanticismo tardío; la interpretación retórica, que interpreta a los personajes de Abel y de Rima como alegóricos; la crítica temática en diversas manifestaciones (naturaleza, barbarie y civilización); lecturas coloniales, postcoloniales e imperialismo cultural; ecocrítica, etc. Finalmente destacaré algunos aspectos narratológicos, como el juego de la “realidad” y la ficción, niveles de extrañeza en el texto literario, y juego de voces.
La conexión entre Japón y la Argentina a través de Guillermo Enrique Hudson: un recorrido por sus vínculos familiares, traducciones y recepción
Authors: Takaki Kana
Published: September 2023

Guillermo Enrique Hudson es un personaje importante para las relaciones entre Japón y la Argentina. Hay dos elementos que lo han ligado con Japón: los vínculos familiares y las traducciones de su obra al idioma japonés. Este trabajo presenta la historia de la familia de Hudson y analiza su recepción en Japón. Los vínculos familiares con Japón empezaron cuando su sobrina Laura se casó con Yoshio Shinya, el primer inmigrante oficial de Japón en la Argentina. Su hija Violeta fue la primera directora del Museo Histórico Provincial “Guillermo Enrique Hudson”. Gracias al trabajo de Violeta, el Museo empezó a colaborar con Japón. Este estudio, a través del análisis de las traducciones de las obras de nuestro autor, revela que su recepción en Japón se desarrolló de cinco modos diferentes: como fuente de información sobre Sudamérica; como literatura inglesa y obra original de la película Green Mansions; como literatura infantil; como historia natural; y, finalmente, como modelo para la enseñanza del inglés.Su legado consolidó los intercambios culturales entre la Argentina y Japón, por lo que el escritor y naturalista se transformó en un verdadero símbolo de las relaciones amistosas entre ambos países.
Ralph Herne, de William Hudson, en el sistema narrativo argentino (1870-1880)
Authors: Molina Hebe Beatriz
Published: September 2023

El objetivo de este trabajo es relacionar la novelística de William H. Hudson con el sistema narrativo argentino vigente hacia 1870-1880. En particular, analizaremos la novela Ralph Herne, publicada en 1888, en Londres, e inspirada en el óleo Un episodio de la fiebre amarilla en Buenos Aires, de Juan Manuel Blanes. Desde el enfoque de la poética histórica, mostraremos que Ralph Herne resulta un producto romántico-realista, gracias a algunos insumos autobiográficos, con los cuales se construye un narrador creíble, y gracias a la pasión como motor de la acción dramática.
Opportunities and outlook for UK Food and Chemicals regulation post EU Exit Workshop Report 2022
Authors: Osborne Olivia , Mulholland Cath , Gant Tim , Botham Phil , Boobis Alan , Wells Sophy
Published: September 2023

1. In 2019, the Royal Society of Chemistry held a workshop: Royal Society of Chemistry (RSC) Workshop of 2019 : Drivers and scope for a UK chemicals framework. Presentations and discussions at this event examined chemical regulation in the United Kingdom (UK) post European Union (EU) exit and the opportunities that might be realised. 2. Since then, several global events have impacted the economy and regulation in the UK, including EU exit. Following these events, the Committee on the Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) decided it would be timely to have a second workshop to build on the successful 2019 workshop by reviewing what has been achieved and what still needs to be done to realise the full potential of EU exit in the area of food and chemical regulation. The purpose of the workshop was to review the food and chemical regulatory landscape; its transfer to the UK; future UK development of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) and divergence (drivers and supporting science); identify the challenges and opportunities to consider where new structures as well as investment are required to realise and address these.
THE MOORE-PENROSE INVERSE OF TRIDIAGONAL SKEW-SYMMETRIC MATRICES. II
Authors: Hakopian Yuri R. , Manukyan Avetik H. , Mikaelyan Hamlet V.
Published: September 2023

This article is the second part of the work started in the previous publication by the authors [1]. The results presented here relate to deriving closed form expressions for the elements of the Moore-Penrose inverse of tridiagonal real skew-symmetric matrices of odd order. On the base of the formulas obtained, an algorithm that is optimal in terms of the amount of computational efforts is constructed.
COMPARATIVE STUDY OF THE CONTENT OF ANTHOCYANINS IN THE FRUITS OF BLUEBERRIES, BLACKBERRIES AND BLACKCURRANTS. DEVELOPMENT OF A TECHNOLOGICAL METHOD FOR OBTAINING PARTIALLY PURIFIED NEW-GALENIC EXTRACTS
Authors: Dadayan Ani S. , Poghosyan Artavazd S. , Ghazaryan Samvel G. , Hovhannisyan Anahit M. , Ghazaryan Melanya S. , Dadayan Slavik A.
Published: September 2023

The work is devoted to a comparative study of the content of anthocyanins in the fruits of blueberries, blackberries and blackcurrants to develop a technological method for producing partially purified extracts. The latter, due to the significant content of anthocyanins, compounds with antioxidant, antiaggregate, angioprotective, anti-inflammatory activities stipulate their use in the complex therapy of ophthalmic diseases (myopia, age-related macular degeneration, diabetic retinopathy). The objects of the study were fresh natural fruits of common blueberries (Vaccinium myrtillus L.), blackberries (Rubus caesius L.) and blackcurrants (Ribes nigrum L.) collected in the foothill landscapes of the city of Aparan of the Republic of Armenia, harvested in 2022. The purpose of this study was to determine the comparative indicators of the quality and content of anthocyanins in fresh fruit extracts by direct spectrometry and obtain environmentally friendly extracts with the lowest content of macro- (Fe, Cu, Zn, Ca, Mg, etc.) and microelements (Mn, Co, Cd, V, Se, Cr, As, Pb, etc.) by ion-exchange sorption and desorption. It has been shown that the highest content of the total amount of anthocyanins in terms of cyanidin-3-O-glycoside is determined in the juice of fresh blueberries in an acidic medium at an analytical wavelength of 546 nm – 4.21 ± 0.18%. At the same time, the completeness of extraction of anthocyanins (≥ 95%) from blueberries is achieved at a ratio of raw material to extractant (95% EtOH, 1% HCl) 1 : 50 and when heated in a boiling water bath for 40 min. It has been shown that the content of these macro- and microelements in the extracts after ion-exchange sorption and desorption with Ku-2×8 (H+) cation exchanger does not exceed the permissible limits.
STUDIES REGARDING THE IDENTIFICATION OF SOME SOLUTIONS FOR THE RENATURATION OF FOREST LANDS WHICH HAVE BEEN USED FOR THE GROWING OF PHEASANTS
Authors: Moldovan Mircea , Tăut Ioan , Șimonca Vasile , Constandache Cristinel , Popovici Laurențiu , Tudor Ciprian
Published: September 2023

In Romania, great importance has been given to growing pheasants, for the repopulation of hunting funds. This activity is carried out in a semi-intensive or semi-natural system. The area where the farms are located must have the following characteristics: the soil must be permeable, must be raised to prevent water stagnation, must be protected from strong winds, must provide shade especially at noon, must be in the quietest areas possible, and last but not least, be suitable for effective disinfection and rodent control. Due to the location conditions and the very large number of birds per surface unit that produce large amounts of bird droppings material, over time, it accumulates in the soil, becoming a limiting factor for the installation of future stands. In the present work, a study was carried out with the objective of establishing the main species that will be used for the afforestation of a land with an area of approx.6 ha, former pheasantry located in Bihor county. Detailed soil analyzes were necessary to substantiate the solutions. Thus, amounts of potassium and phosphorus far above the optimal amount were determined, and the hydro-physical characteristics of the soil were strongly affected, requiring special pedoameliorative works.
Experimental Study on Panchanan Rasa w.s.r. to its Acute Oral Toxicity
Authors: Satyam Bhargava  , Rajkishore Pati
Published: September 2023

Ras sashtra is a specialized branch of Indian traditional system and medicine which deals with metals, minerals, herbal compounds, and various principles of alchemy and metallurgy etc. Panchanan Rasa chief reference is in Ras Ratna Sammuchya Hridya Roga Chikitsa for Hridya Roga. It is a herbo-mineral preparation made with the help of Kharal so called Kharaliya preparation and is used in powder form to be given to patient. In present era Hridya Roga is becoming a common problem, every one person in ten people is suffering from CAD/IHD with varied etiology and is going under long term medication, costly surgeries which every patient is not able to afford, so this article discuss about the acute oral toxicity of Panchanan Rasa and found it non-toxic on Albino rats.
An Approach to Periarthritis of Shoulder Joint an Ayurvedic Perspective
Authors: Anu P Sunder  , Sreelekha M P  , Aneesh S
Published: September 2023

Periarthritis of the shoulder is a painful, progressive, and disabling disease involving the shoulder joint. The structures involved in the disease are joint capsule, tendons, ligaments, and bursae. As the shoulder movements are painful, the disease makes homemakers, software professionals, skilled workers, manual labourers, and athletes’ lives miserable. The patients were unable to do routine activities like combing hair, dressing, undressing, and doing overhead activities. The initial stages of the disease can be correlated with features of Amsa sandhi sopha having Raktha pitha predominance. The procedures like Lepanam, Upanaham, and internal medications adopted in this stage do not give permanent and complete relief from symptoms. Jaloukavacharana (leech therapy) is selected in the present study by considering the Dosha vitiation - in the initial stages of the disease, as it has anti-inflammatory and analgesic effects. Three Jaloukas (leeches) are applied at a time with intervals of three weeks over the glenohumeral joint (shoulder joint). Assessments were done before treatment, 8th, 15th and 22nd days. The results showed Jaloukavacharana was effective in the first stage of the disease.
Role of Ayurveda, Lifestyle Modification, and Panchakarma Therapy on Stabilization of Atherosclerotic Plaque in Known Coronary Artery Disease Patient
Authors: Deepali Amin  , Nilesh Kulthe  , Rahul Mandole
Published: September 2023

Atherosclerois is a major health concern in India and imposes a significant burden on the population. The prevalence of risk factors such as hypertension, obesity, smoking and high cholesterol levels contribute to the rising incidence of atherosclerosis in the country. A 57-year-old male presented with primary complaints of chest pain and heaviness, left arm pain, upper back pain, jaw pain, dyspnea on exertion grade I, flatulence, gaseous distension, cervical pain, scapular region pain, shoulder pain, constipation, and insomnia. He also complained of postprandial angina New York Heart Association (NYHA) Class III. The patient was a photographer by profession and had a history of hypertension, diabetes mellitus, and coronary artery disease. On 29th February 2020, he underwent computed tomography (CT) coronary angiography at another clinic which revealed stenosis of the 3 main coronary arteries – more than 90% stenosis in mid left anterior descending artery (LAD), 80–90% stenosis in proximal left circumflex artery (LCx), and 80–90% stenosis in proximal right coronary artery (RCA). The patient was advised an Ayurveda-based low-carbohydrate high antioxidant diet of 1,000 calories daily for the first 12 weeks. This case report supports the relationship between an Ayurveda-based low-carbohydrate high antioxidant diet and atheroma regression in a high-risk coronary artery disease patient.
Sunthi Bilwa Kwath with Yava Saktu in Garbhini Chardi (Emesis Gravidarum) - A Systematic Literature Review
Authors: Anita Basumatary  , Yanbeni Humtsoe  , Kaushalya Khakhlary
Published: September 2023

There are various minor ailments occur during pregnancy, where nausea and vomiting are usually common in early pregnancy. Vomiting in early weeks of pregnancy, mentioned as Garbhini Chardi (Emesis Graviderum) in Vyakt Garbha Lakshana in classics. If this vomiting is not corrected at right time, it may cause many complications later. Due to sedentary lifestyle, changed food habits, stress etc. has made pregnancies more difficult in today’s era. Modern obstetrics practice manages emesis gravidarum using drugs like anti-emetics, antacids, giving nutritional support with vitamin B1, B6, B12. Moreover, drugs like anti-emetics etc. subsides the symptoms but they are having some minimal side effects too such as constipation, dysuria, urinary retention etc. So, Ayurveda approach is found to be very useful in such condition, many formulations are mentioned in our classics which can be incorporated in daily life by pregnant woman. Acharya Yogaratnakar in Streeroga Chikitsa have mentioned many herbal formulations for garbhini Chardi. Here, Sunthi Bilwa Kwath with Yava Saktu formulation may subsides the vomiting during pregnancy due to Kasaya Ras and Ruksha Guna of Bilwa and Yava Saktu, Deepan, Pachan karma of Sunthi and Bilwa, Chardighna Properties of Yava. So here a systematic literature review of Sunthi Bilwa Kwath with Yava Saktu in the management of Garbhini Chardi will be discussed.
Management of Vipadika (Palmo-Plantar Psoriasis) by Ayurveda
Authors: Jadhav Tejaswini Shirish  , Chaudhari Vivek Murlidhar
Published: September 2023

An immune-mediated condition known as psoriasis causes persistent skin inflammation. Palmoplantar psoriasis, a kind of psoriasis that is difficult to cure, affects about 5% of all psoriasis patients. In Ayurveda, all skin conditions are referred generally under the term ‘Kushtha’. One such illness that has been classified as Kshudra Kushta is called Vipadika and is marked by symptoms like Pani-pada Sphutan (Fissure in the palms and soles) and Teevra vedana (with great pain). The main causes of its expression include vitiation of Vata, Kapha, and Pitta/Rakta. In present case report, a 54 years female patient presented in OPD 2 of Sane Guruji Rugnalaya, Hadapsar, Pune, with complaints of dryness and cracking of both soles associated with itching and pain for 1 year and was treated with oral medicines and external application of Gandharva Haritaki and Gorakhmundi Ghrita Siktha respectively. After complete treatment of 30 days, there was complete remission in the symptoms and there is no recurrence till date. From the current case report, it can be inferred that Vipadika (palmo-plantar psoriasis) can be successfully treated with the appropriate Ayurveda medications
Análisis de internaciones en el servicio de clínica médica, impacto de la diabetes mellitus
Authors: Ferrada Pablo
Published: September 2023

Introducción: uno de cada cuatro pacientes admitidos en un nosocomio tiene diagnóstico previo de diabetes (DM), siendo frecuentes los reingresos hospitalarios en un mismo año. La internación puede relacionarse con una complicación de la DM o más comúnmente con otra patología.

Objetivos: determinar en pacientes internados en el Servicio de Clínica Médica (CM) del Hospital General de Agudos de tercer nivel de complejidad de Mendoza: prevalencia de DM, causas de hospitalización, estadía hospitalaria, internaciones previas y reingresos, mortalidad, y realizar una comparación entre pacientes con o sin DM (DM, no-DM respectivamente).
COVID-19 Symptomatology from the Otorhinolaryngology Perspective: Survey from Tertiary Care Center
Authors: Hussain Raj Tajamul , Yadav Mayank , Monga Jasdeep
Published: September 2023

Introduction

To identify and substantiate the prevalence and severity of different otolaryngological symptoms documented in laboratory-confirmed COVID-19 patients.

Materials and Methods

This monocentric study was performed at SHKM Hospital during the COVID-19 pandemic and all patients testing positive for COVID-19 over a 16-month period (April 2020 to July 2021) were recruited. Demographic features, general symptoms, and otolaryngological symptoms were evaluated and compared by disease severity. Patients with otolaryngological manifestations were asked to complete questionnaires and their symptom severity was evaluated using visual analogue scale (VAS).

Results

722 patients with mild to moderate COVID-19 infection were included in the study. Median age was 37.7 ± 10.6 years (range 19–85 years), 66.20% (n = 478) were males and 33.79% (n = 244) were females. The most common general symptoms were fever, cough and fatigue/malaise with respective frequencies of 77.42%, 67.45% and 54.70%. The most common otorhinolaryngologic symptoms were sore throat, headache and olfactory dysfunction with respective frequencies of 19.52%, 17.03% and 14.81%. Highest general symptom severity was for fever (median VAS =8) and highest otolaryngologic symptom severity was for hyposmia/anosmia (median VAS =8).

Conclusion

Otolaryngologic manifestations of COVID-19 are not as common as fever and cough. However early recognition of otolaryngologic manifestations should help to screen, identify and thereby quickly isolate symptomatic COVID-19 patients from the general population and also facilitate care givers to take necessary precautions to protect themselves.
Management of Nasoalveolar Cyst by Transnasal Endoscopic Marsupialization
Authors: Grover Mohnish , Nirwan Siddharth , Nahar Rahul , Soni Samanvaya
Published: September 2023

Introduction: A nasoalveolar cyst is a benign nonodontogenic mass situated in the anterior region of the maxilla. They are often located submucosally in the anterior nasal floor giving rise to swelling in the nasolabial area at the base of nasal alae. Traditionally, the approach of choice was intraoral sublabial marsupialization, however the trend is shifting to lesser invasive and scarless transnasal endoscopic marsupialization.

Materials and Methods: This is a retrospective observational study comprising of 16 patients who underwent microdebrider assisted endoscopic transnasal marsupialization of nasoalveolar cyst.

Results: 16 patients underwent endoscopic transnasal marsupialization under general anaesthesia. They were followed up for 6-16 months (mean 9.43) and none of them had any recurrence.

Conclusion: The traditional treatment for the same has been by external approach. However, a scar in this area of face is not acceptable for many. Also, it is not easy to excise the whole cyst in toto. In our experience, microdebrider assisted endoscopic transnasal marsupialisation is an easier, faster, safer, and equally efficacious technique to treat nasolabial cyst without any recurrence. 

Key words: nasoalveolar cyst; nasolabial cyst; endoscopic marsupialization
Desenvolvimento e validação de métodos para determinação de trialometanos e ácidos haloacéticos em águas tratadas
Authors:   , Oliveira Kleryton Luiz Alves de
Published: September 2023

No processo de desinfecção realizado nas estações de tratamento de água (ETA), o cloro é amplamente utilizado como agente desinfetante. Apesar de seus benefícios, o cloro reage com a matéria orgânica e produz subprodutos indesejados, como ácidos haloacéticos (HAAs) e trialometanos (THM), que possuem potencial carcinogênico. A Portaria nº 888 estabelece limites máximos permitidos de 0,08 e 0,1 mg L -1 para a soma de nove HAAs e soma de cinco THM, respectivamente. Portanto, teve-se por objetivo desenvolver e validar um método para a determinação de THM e um método de determinação HAAs em água tratada. O método de determinação de THM baseou no emprego da reação entre trihalometano, piridina e NaOH para formação de um composto colorido e monitoramento por Espectrofotometria na região visível. O método foi validado de acordo com os critérios estabelecidos pelo INMETRO. As curvas analíticas apresentaram R2 > 0,98. Os limites de detecção (LD) e quantificação (LQ) foram inferiores a 13,41 μg L-1 e 40,65 μg L-1, respectivamente. A recuperação ficou entre 86,1 e 90,7% e precisão intermediária inferior a 13,6%. Foram coletadas 19 amostras de água da rede de distribuição da ETA-UFV, que apresentaram concentrações entre 13,58 e 55,46 μg L-1, todas dentro do limite estabelecido pela legislação. O método é simples e de baixo custo, tornando-o adequado para uso em laboratórios de estações de tratamento de água. Para a análise dos ácidos HAAs, foi utilizada a técnica de Cromatografia a Gás acoplada a Espectrometria de massas (GC-MS). O método também foi validado, apresentando curvas analíticas com R2 > 0,99. O LD e LQ foi inferior a 11,05 e 31,53 μg L-1, respectivamente. As recuperações ficaram entre 79,6 e 95,2% e precisão intermediária inferior a 4,6%. A eluição de todos os analitos ocorreu em 12,5 minutos, apresentando uma melhoria significativa em relação a outros trabalhos da literatura. Por fim, estudos preliminares envolvendo a cinética de decomposição de cloro de hipoclorito, dicloroisocianurato (dicloro) e tricloroisocianúrico (tricloro), que são oxidantes usados na desinfecção da água, foram realizados. O modelo cinético de pseudo primeira ordem foi ajustado aos dados, que apresentou valores para constante cinética de 0,05402; 0,08214 e 0,09678 min-1 para tricloro, dicloro e hipoclorito, respectivamente. O dicloro e o tricloro são compostos estabilizados devido à presença do ácido cianúrico, o que faz com que liberem lentamente o ácido hipocloroso. Por fim, a decomposição de ácidos húmicos foi monitorada na presença de hipoclorito. Esses ensaios preliminares permitiram determinar as condições necessárias para avaliar a formação de THM e HAAs a partir de matéria orgânica para serem monitorados pelas técnicas analíticas validadas. Palavras-chave: Cloro. Validação de Métodos Analíticos. Cromatografia.