bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness and use of prophylactic antibiotics in elective and emergency caesarean section at tertiary care hospital
Authors: Lingam K. Rama , Ramineni Hari Babu , Firdous Shaik Gulshan , Yamuna P. , Madhuri B. , Chidrupi D. N. S. S.
Published: April 2020

Background: Post-operative infections in obstetrics and gynecological settings have been higher compared to other specialties. Women undergoing caesarean section have 5 to 20-fold greater risk for infection compared with vaginal delivery. Many studies reported antimicrobial prophylaxis prevent post-operative infections. Hence this study concentrates the evaluation of the prescribing antimicrobial use and to assess the frequency of post-operative morbidity related to infection in subjects undergoing caesarean section. The aim of the study was to analysis the effectiveness, prophylactic antibiotics (amoxicillin versus ceftriaxone) and to evaluate the post-operative (caesarean) infections in patients undergoing lower segment caesarean section (elective and emergency).Methods: This is a prospective observational study which assessed the effectiveness and use of prophylactic antibiotics in patients undergoing cesarean section at department of obstetrics and gynecology. The study was conducted over a period of one year.Results: The corresponding mean age of all the study population in amoxicillin group (n=113) was 56.5±28.5 and in ceftriaxone group (n=97) was 48.5±26.5 respectively. The participant who underwent previous cesarean section in amoxicillin group is 65.48% similarly in ceftriaxone group is 47.42%. The patients with fetal distress in ceftriaxone group are 14.77% and in amoxicillin group is 8.92%. Failed induction in amoxicillin group is 9.82% and in ceftriaxone group is 6.81%. The number of days in hospital stay in amoxicillin group is 42.42% and in ceftriaxone group is 45.94%. The post-operative complications in amoxicillin group reported, with Febrile Illness are 40% and wound Infection is 60%.Conclusions: Administration of pre-operative antibiotics significantly reduce post-operative infections. Use of ceftriaxone as a prophylactic antibiotic in patients undergoing lower segment caesarean section (elective and emergency) is more effective than Amoxicillin in preventing post-operative infections.
Knowledge, attitudes and practices of cervical cancer screening by health care providers in the Emana health area: Yaounde-Cameroon
Authors: Hortence Fouedjio Jeanne , Sophie Mawamba Sonfack , Brigitte Wandji , Florent Fouelifack Ymélé , Charlette Nangue , . Ngaroua , Dupont Kemfang Ngowa Jean
Published: April 2020

Background: Gynaecological cancers and more particularly those of the cervix cause many victims in our country despite the many prevention tools that exist. The objective of this study was to assess the knowledge, attitudes and practices of providers on cervical cancer in the Emana health area.Methods: To achieve this objective, we conducted a cross-sectional study form the period from April 2nd to June 10th, 2019 in the health facilities of the Emana health area.Results: A total of 64 healthcare providers participated in the study, 03 gynecologists and obstetricians, 10 General practitioners, 30 state-certified nurses, 09 midwives, 12 nursing assistants. The majority of these providers had poor knowledge of the causes of the disease (25%), risk factors (34.4%), and means of prevention (39.1%), especially among state nurses (SRN), midwives, nursing assistants. (87.5%) had good knowledge of the clinical signs of the disease and were almost unanimous on the curability of this disease when discovered early (78.1%). The severity of the cancer was perceived by all; however, the practice of screening was low (10.9%). As for their personal screening practices, 73.1% (38/52) of female staff had never been screened.Conclusions: Even though the participants perceive the grave nature of the cervical cancer, the subsequent attitude and screening practices remain poor. The possible barrier to this is the insufficient continuous training and recycling of the health personnel. Emphasis should be laid on the methods of prevention of cervical cancer in the curricula of nurses and midwives in Cameroon.
Antenatal diagnosis of alobar holoprosencephaly
Authors: Khanna Dolly , Bhatti Karandeep S.
Published: April 2020

Holoprosencephaly (HPE), a congenital induction disorder, occurs due to failed segmentation of neural tube and subsequent incomplete separation of the prosencephalon. Because of the defect in the ventral induction, HPE is also associated with multiple facial abnormalities. Mortality correlates with the severity of brain malformation and facial phenotype. Frequent causes of death include respiratory infections, dehydration due to uncontrolled diabetes insipidus, intractable seizures, and brainstem malfunction. This is a case of Alobar holoprosencephaly in the fetus of a 31-year-old G2P1 female, detected on level II obstetric ultrasound at 17 weeks of gestation. The objective of this case report is to discuss the etiology, pathogenesis, prenatal sonographic findings, management and prognosis of HPE which can aid in its early antenatal diagnosis and can help formulate an adequate plan for the parents and fetus.
An interesting case report of ruptured pyogenic liver abscess with 40 weeks gestation in labour
Authors: Mevada Shraddha A. , Bhosale Archana A. , Wankhedkar Sayali , Choudhari Rucha
Published: April 2020

Pyogenic liver abscess during pregnancy is an extremely rare condition. Although rare, in situations of sepsis or septic shock in pregnancy, as well as the common sources of infection, a possibility of a liver abscess should be considered. We present a case report of 32-year-old primigravida 37.3 weeks by date, 37 weeks by scan with breech presentation with premature rupture of membranes and pain in abdomen since 12 hours with breathlessness, fever and diarrhoea since 2 days came in emergency to study hospital. General condition of the patient on arrival was pulse-140 beats per minute, blood pressure was 90/60 mmHg, respiratory rate was 40/min, on per abdominal examination, breech presentation with fetal heart rate of 150 beats per minute on doppler was noted. Per vaginal examination revealed cervical os 5 cm dilated, 40% effacement, breech presentation, absent membranes. With urgent report of complete hemogram and acid blood gas analysis, metabolic acidosis was noted which was corrected and patient was taken for emergency lower segment caesarean section. Intra-operative, 250 ml greenish pus flakes fluid was noted inside the abdominal cavity. Fluid was drained and sent for culture sensitivity with maximum aseptic precautions, uterus was opened, baby was delivered followed by uterus closure. Ruptured liver abscess 6×4×2 cm in 2nd and 3rd segment of liver was noted, abdominal wash with antibiotics and NS was given, drain was kept. Appropriate antibiotics were started and was discharged on day 14 after suture removal.
Modeling the generation of optical modes in a semiconductor waveguide with distributed feedback formed by a space charge wave
Authors:   Ulyanovsk State University, Dadoenkova Yu.S. ,   Lab-STICC, Zolotovsky I.O. ,   Ulyanovsk State University, Panyaev I.S. ,   Ulyanovsk State University, Sannikov D.G. ,   Ulyanovsk State University
Published: April 2020

The amplification and generation of optical TE waves arising on a lattice formed by a space charge wave in a planar waveguide based on a donor-doped semiconductor (gallium arsenide) n-GaAs are considered. The region of interaction is limited by contacts with a constant electric field applied between them, which, while operating in the Gunn oscillations suppression mode, gener-ates a small-signal periodic inhomogeneity. Reflection and transmission regimes for same-index TE modes propagating in the waveguide structure are investigated depending on the phase mis-match and the pump level. It is shown that even with a relatively small modulation depth of the di-electric constant (about 10–5), under conditions of high optical pumping (with a gain of about 150 cm–1) and a corresponding detuning from phase matching there is the possibility of not only ampli-fying the direct and backward (reflected) optical modes, but also their generation. The advantage of the considered effects is that they enable flexible control of parameters of the dynamic lattice. The results obtained can be used to create semiconductor laser generators based on the interaction of the optical modes and a space charge wave.
Parallel machine arithmetic for recurrent number systems in non-quadratic fields
Authors:   Samara National Research University, Chernov V.M. ,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS
Published: April 2020

The paper proposes a new method of synthesis of computer arithmetic systems for "error-free" parallel calculations. The difference between the proposed approach and calculations in traditional systems of Residue Number Systems for the direct sum of modular rings is the parallelization of calculations in non-quadratic extensions of simple finite fields whose elements are represented in number systems generated by sequences of powers of roots of the characteristic polynomial of the recurrent sequence.
Efficiency of machine learning algorithms and convolutional neural network for detection of pathological changes in MR images of the brain
Authors:   Samara National Research University, Agafonova Yu.D. , Gaidel A.V. ,   Samara National Research University,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Zelter P.M. ,   Samara State Medical University, Kapishnikov A.V. ,   Samara State Medical University
Published: April 2020

We compare approaches for the automatic detection of pathological changes in brain MRI images that are visible to the naked eye. We analyse multi-stage approaches based on deep learning and threshold processing. A convolutional neural network was formed, a classifier was built based on the use of an ensemble of decision trees, and an algorithm was created for multi-stage image processing. Because of experimental studies, it was found that the most effective method for recognizing images of magnetic resonance imaging is an approach based on an ensemble of decision trees. With its help, 95 % of the images from the test sample were classified correctly. At the same time, using the convolutional neural network, it was possible to classify correctly all images containing the area of pathological changes. The data obtained can be used in practice for the diagnosis of brain diseases, for automating the processing of a large number of studies of magnetic resonance imaging.
Resonance characteristics of transmissive optical filters based on metal/dielectric/metal structures
Authors:   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Nesterenko D.V. ,   Samara National Research University
Published: April 2020

The resonance characteristics of the Fabry-Pérot resonator modes supported by metal/dielectric/metal planar structures are studied in the case of absorbing media for near-to-normal light incidence. Approximations based on rigorous solution and field-transfer model for the field and resonance line shapes in spectra are attributed to the class of Fano and Lorentz resonances. The analytical expressions are obtained for the propagation constant and field enhancement of the mode, width, height and slope of resonance line shapes in spectra as functions of structural parameters. With estimation of field characteristics of the fabricated loss structures based on aluminum and quartz, the peaks in the transmission spectra can be attributed to the excitation of Fabry-Pérot modes. Fundamental characterization of Fabry-Pérot resonances may find applications in optical processing and sensing.
Method for selection macular edema region using optical coherence tomography data
Authors:   Samara National Research University, Ilyasova N.Yu. ,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Demin N.S. ,   Samara National Research University,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Shirokanev A.S. ,   Samara National Research University,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Kupriyanov A.V. ,   Samara National Research University,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Zamytskiy E.A. ,   Samara Regional Clinical Ophthalmological Hospital named after T.I. Eroshevsky
Published: April 2020

The paper proposes a method for selection the region of diabetic macular edema in fundus images using OCT data. The relevance of the work is due to the need to create support systems for laser coagulation to increase its effectiveness. The proposed algorithm is based on a set of image segmentation methods, as well as searching for specific points and compiling their descriptors. The Canny method is used to find the boundary between the vitreous body and the retina in OCT images. The segmentation method, based on the Kruskal algorithm for constructing the minimum spanning tree of a weighted connected undirected graph, is used to select the retina to the pigment layer in the image. Using the results of segmentation, a map of the thickness of the retina of the eye and its deviation from the norm were constructed. In the course of the research, the optimal parameter values were selected in the Canny and graph segmentation algorithms, which allow to achieve a segmentation error of 5 %. SIFT, SURF, and AKAZE methods were considered for super-imposing calculated maps of the retina thickness and its deviation from the norm on the fundus image. In cases where a picture from the fundus camera of the OCT apparatus is provided along with OCT data, using the SURF method, it is possible to accurately combine with the fundus image.
Measures of labour market accessibility. What can we learn from observed commuting patterns?
Authors: Osland Liv , Gjestland Arnstein , Thorsen Inge
Published: April 2020

It is well known that measures of labour market accessibility explains spatial variation in housing prices even in markets with polycentric labour market structures. This paper examines whether data on observed commuting patterns can replace or supplement gravity-based measures representing the commuting potential at specific locations. We use data from a region in Western Norway,and we find that measures based on observed commuting flows and commuting time cannot replace a gravity-based measure of labour market accessibility. Based on, inter alia, the spatial Durbin estimator we find that measures of observed commuting flows increase the explanatory power of a hedonic house price model.
The Impact of Surfactants on Separation of Mixed Polymer Wastes in Electrostatic Field
Authors: Gonopolsky A.M. , Poluosmak E.A.
Published: April 2020

A quantitative analysis is carried out of such factors as electrostatic intensity, surface area of particles, dielectric permittivity, size polymer particles, and the type and concentration of surfactants, by the amount of electric charge of the polymer surface, obtained in the electrostatic field after their pre-treatment of surfactants. Dependencies of the maximum charge of polymer waste particles from the basic technological parameters of the drum electrostatic separator and physical-chemical properties of polymers and surfactants are shown. It has been found that degradation of polymeric waste in a surfactants aqueous solutions is an effective preliminary step of technology of electrostatic separation of a mixture of crushed polymer wastes that positive effect on their charging in an electrostatic field. The obtained data allows to develop the technological process precision selective separation of mixed polymer materials in an electrostatic field.
Universal Bench for Full-Scale Testing of filters FOPS®. Oil products
Authors: Fedorov M.P. , Maslikov V.I. , Chechevichkin A.V. , Yakunin L.A.
Published: April 2020

The problem of testing equipment designed for the treatment of surface wastewater contaminated with oil products is considered. The current level of development of installations for testing treatment equipment is shown. The possible methods of treatment of surface wastewater from oil products are highlighted, and the features of the treatment process depending on their phase state are described. The main requirements for the technical device and characteristics of the testing equipment for the treatment of surface wastewater contaminated with oil products are identified. The design of the developed full-size FOPS® filter test bench is presented, the procedure for working on it is described, the results of studies on modeling the process of treatment surface runoff contaminated with emulsified and truly dissolved oil products are presented.
Technogenic and Environmental Risks: Krasnoyarsk Territory, Republic of Sakha (Yakutia)
Authors: Moskvichev V.V. , Prokhorov V.A. , Ivanova U.S.
Published: April 2020

The article discusses The methodological aspects and presents the results of the assessment of territorial risks for socio-natural-technogenic (S-N-T) systems are discussed. In work have presented the calculations of individual and material risks emergencies in the Krasnoyarsk territory and the Republic of Sakha (Yakutia). The main techno-dangerous objects of territories are allocated and possible technogenic dangers with an assessment of the main indicators of pollution of natural environment are shown. As an example, the production associated with the production of petroleum products and minerals, reservoirs and tailings. Territorial technogenic risks of emergencies for the Krasnoyarsk territory and the Republic of Sakha (Yakutia) are analyzed.
Disturbed Lands: Current Status and Problems of Rational Use (on the Example of Samara Region)
Authors: Vasilieva D.I. , Vlasov A.G. , Tarbaev B.A. , Kholopov Yu.A.
Published: April 2020

The problems of pollution of agricultural land in the region have been considered, the main sources and types of pollution have been analyzed, legal, methodical and environmental documents on land reclamation have been studied. Activities on the reclamation of disturbed agricultural land are presented on the example of land-use facilities of natural monopolies in the Samara region.
Assessment of Heavy Metals Distribution in Soil Cover of Industry-Urban Area of Krasnoyarsk
Authors: Muchkina E.Ya. , Badmaeva S.E. , Korotchenko I.S. , Gorlushkina K.S.
Published: April 2020

The results of analysis of heave metals concentration in soil and subsoil of large urbanized area are presented. The dates of observation from 2014 to 2016 are presented. The 108 soil samples from 12 monitoring areas were analyzed. The distribution of mobile forms of heavy metals in the soil cover within Krasnoyarsk city are considered. The rate of soil pollution was studied. It was discovered soil pollution with Pb, Cu, Ni, Zn, Mn, Cd, Co exceeds maximum acceptable concentration (MAC). Geochemical associations of heavy metals for functional specialization areas were established. The indices of accumulation of heavy metals can be used to the monitoring to urban territories.
Comparison of Intravenous Enoxaparin with Subcutaneous Enoxaparin in Preventing Venous Thromboembolism in Patients Admitted to Intensive Care Unit
Authors: Khoshfetrat Masoum , Khorram Majid , Keykha Aliakbar , Ansari Hossein
Published: April 2020

Background: The use of subcutaneous enoxaparin is a usual method for preventing venous thromboembolism (VTE) in the intensive care unit (ICU) patients, but adequate absorption of the drug is not reliable due to the illness intensity, existing edema and hypoperfusion in these patients. The aim of this study was to compare the effect of intravenous enoxaparin with subcutaneous enoxaparin to prevent VTE in ICU patients.
Methods: The current double-blind Randomized clinical trial was performed on 64 patients admitted to the ICU at Khatam- Al- Anbia Hospital in Zahedan, southeast of Iran. The patients were randomly assigned into each of the subcutaneous enoxaparin and the intravenous enoxaparin groups. The blood sampling was performed aseptically and then active factor Xa level was measured. Next, the intervention group received 0.5 mg/kg of intravenous enoxaparin for 10 days and the control group was injected subcutaneously the same dosage of drug. Four hours after the first injection and 12 hours after the last injection on the tenth day, the factor Xa level and the frequency of VTE incidence was measured again.
Results: In all three measurement times, the active factor Xa level in the intravenous enoxaparin group was lower than that of the subcutaneous group, but no significant difference was observed between the two groups and different times (P> 0.05).
Conclusion: The results of this study showed that the use of intravenous enoxaparin is an effective way to prevent the VTE development in the ICU patients.
The Effect of Intra-Operative Plethysmography Variability Index-guided Fluid Therapy on Serum Lactate Levels; A Randomized Double-blinded Clinical Trial
Authors: Azimaraghi Omid , Heroabadi Arash , Saliminia Alireza , Atefyekta Reza , Saberian Peyman , Dehghanbanadaki Hojat , Khazaei Noushin , Movafegh Ali
Published: April 2020

Background: Goal-directed fluid therapy may improve perioperative fluid management. This study aimed to evaluate the effects of Pleth variability index (PVI)-guided fluid therapy on changes in intraoperative serum lactate levels in comparison with liberal fluid therapy.
Methods: This study was a randomized double-blinded clinical trial that was conducted in the operating room of a university hospital. Inclusion criteria comprised patients aged 18–60 years and classified as American Society of Anesthesiologists physical status class I and II, who were candidates for elective thyroidectomy. In total, 44 patients meeting the inclusion criteria were enrolled in the study and randomly assigned to two groups: the liberal and PVI groups. In both groups, 5 mL/kg bolus of normal saline was infused prior to the anesthesia induction. In the PVI group, 100 mL bolus of normal saline was administered every 5 min if the PVI remained >13% during the operation. In the liberal group, continuous crystalloid infusion (5–6 mL/kg/h) was administered throughout the surgery. Arterial blood samples were taken, and serum lactate levels were measured following anesthesia induction and just before tracheal extubation.
Results: In the PVI group, mean serum lactate decreased at the end of the surgery, with a difference of −0.6 ± 0.13 mmol/L, whereas it increased in the liberal group (0.070 ± 0.3, P<0.05).
Conclusion: In conclusion, we found that using intraoperative PVI-guided fluid therapy could decrease serum lactate levels and total fluid administration compared to the liberal method.
Investigating the Frequency of Pressure Ulcers and Their Effective Factors in Intensive Care Units
Authors: Khoshfetrat Masoum , Keykha Aliakbar , Nasrolahi Saman , Farahmandrad Reza , Behnampour Mohammad
Published: April 2020

Background: For patients with prolonged bed rest and immobilization because of motor or consciousness disorders, many factors may contribute to the development of pressure ulcers. To this end, the present study aimed to investigate the frequency of pressure ulcers and the factors affecting the development of this condition in intensive care units (ICUs).
Methods: In this descriptive cross-sectional study, the case files and records of patients hospitalized between March 2017 and March 2018 entered the study using the census method. The necessary information including age, gender, location of pressure ulcers, number of ulcers on each part of the body, length of stay in ICU, and underlying diseases was extracted from the files and recorded in the data checklist. In the end, the extracted data were analyzed with SPSS 25.
Results: Of the 781 patients studied, 71 (9.1%) had pressure ulcers, of whom 34 were men and 37 were women. A statistically significant difference was found between men and women in terms of the incidence of pressure ulcer (p = 0.0013). The most common sites of pressure ulcers were buttock with 34 cases (47.9%) and sacrum with 21 cases (29.6%).
Conclusion: Old age and prolonged stay in ICU are important determinants of the development of pressure ulcers.
High-level Expression and One-step Purification of Chimeric Antigen Containing HTLV-I/-II Diagnostic Epitopes in Escherichia coli
Authors: Bezhgi Mahnaz , Fazilati Mohammad
Published: April 2020

Purification and preparation of three diagnostic antigens used for the detection of human T-lymphotropic virus (HTLV)-I/-II infection in E.coli are different parts of a multi-step method. In this study, our aim was to design a chimeric protein for the simultaneous detection of HTLV-I and HTLV-II antibodies.
Immunodominant B cell linear epitopes of envelope and capsid proteins of HTLV-I/-II were selected and linked together; using a suitable amino acid linker and a chimeric antigen (CA). The codon-optimized synthetic DNA encoding the CA was subcloned into the pGS21aexpression vector and CA expressed as His-GST fused protein in E. coli BL21 (DE3) cells. Then the recombinant CA was purified, using the Ni-NTA (Nickle Nitrilotriacetic acid) affinity chromatography under native conditions.
The Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and densitometric scanning results showed that CA accounted for 15% of the total cellular proteins and approximately 50% of the expressed histidine-glutathione s-transferase-chimeric antigen (His-GST-CA) proteins were soluble. The CA was successfully purified in one step with a purity of greater than 90%, which is suitable for antigenicity evaluations. Enzyme-linked immunosorbent assay (ELISA) results showed that the GST fused CA reacted in a concentration-dependent manner with HTLV-I/-II infected sera and was able to distinguish normal serum from HTLV-I/-II infected one with a proper sensitivity.
With further validation, CA, as described in the present study could be introduced as a novel reliable, cost-effective and easy alternative for the three separate HTLV-I/-II diagnostic peptide antigens, which is prepared as a fusion with GST.
Immunogenicity Evaluation of Recombinant Staphylococcus aureus Enterotoxin B (rSEB) and rSEB-loaded Chitosan Nanoparticles Following Nasal Administration
Authors: Hosseini Seyed Amir , Nazarian Shahram , Ebrahimi Firouz , Hajizade Abbas
Published: April 2020

Staphylococcal enterotoxin B (SEB), apotent superantigen, is responsible for many disorders caused by Staphylococcus aureus. With regard to the appearance of multidrug-resistant strains of the bacteria, there is a great need to develop an efficient vaccine against this pathogen. In the present study, the immunogenicity of recombinant SEB was evaluated following nasal administration to BABLB/c mice. Indeed, the rSEB protein was entrapped into chitosan nanoparticles and the immunogenicity of nano-formulation was investigated.
SEB protein was expressed in E. coli BL21 (DE3) and purified by using a nickel column. Chitosan nanoparticles were synthesized in the presence of rSEB; using the ionic gelation technique. Synthesized NPs containing rSEB and bare rSEB were administered to mice nasally.
Serum and stool IgG and IgA antibody showed that both formulations were able to evoke the mice's immune responses and there was no significant difference between them. Results of the toxin neutralization test on Vero cells indicated that the sera of the immunized mice had an inhibitory effect on the growth of these cells (p<0.001).
Nasal administration of bare rSEB could efficiently simulate the mice's immune system and nano-delivery of this protein via nasal route had not a significant impact on its immunogenicity improvement.
Optimized Dose of Dendritic Cell-based Vaccination in Experimental Model of Tumor Using Artificial Neural Network
Authors: Mirsanei Zahra , Habibi Sima , Kheshtchin Nasim , Mirzaei Reza , Arab Samane , Zand Bahareh , Jadidi-Niaragh Farhad , Safvati Aida , Sharif-Paghaleh Ehsan , Arabameri Abazar , Asemani Davud , Hadjati Jamshid
Published: April 2020

Previous studies have demonstrated that maturation of dendritic cells (DCs) by pathogenic components through pathogen-associated molecular patterns (PAMPs) such as Listeria monocytogenes lysate (LML) or CpG DNA can improve cancer vaccination in experimental models. In this study, a mathematical model based on an artificial neural network (ANN) was used to predict several patterns and dosage of matured DC administration for improved vaccination.
The ANN model predicted that repeated co-injection of tumor antigen (TA)-loaded DCs matured with CpG (CpG-DC) and LML (List-DC) results in improved antitumor immune response as well as a reduction of immunosuppression in the tumor microenvironment. In the present study, we evaluated the ANN prediction accuracy about DC-based cancer vaccines pattern in the treatment of Wehi164 fibrosarcoma cancer-bearing mice.
Our results showed that the administration of the DC vaccine according to ANN predicted pattern, leads to a decrease in the rate of tumor growth and size and augments CTL effector function. Furthermore, gene expression analysis confirmed an augmented immune response in the tumor microenvironment.
Experimentations justified the validity of the ANN model forecast in the tumor growth and novel optimal dosage that led to more effective treatment.
Autologous Whole-blood Injections in Chronic Spontaneous Urticaria: Assessment of Efficacy Biomarkers
Authors: Kitsioulis Nikolaos Aggelis , Zafiriou Efterpi , Xepapadaki Paraskevi , Taka Styliani , Papadopoulos Nikolaos G. , Roussaki-Schulze Angeliki-Viktoria
Published: April 2020

There is no Abstract.
Production and Characterization of Monoclonal Antibody against Vit v1: A Grape Allergen Belonging to Lipid Transfer Protein Family
Authors: Hosseinpour Mitra , Mashayekhi Kazem , Falak Reza , Jamalzehi Sirous , Mohammadian Haftcheshmeh Saeed , Mousavi Mohamad Javad , Soleimani Anvar , Koushki Khadijeh , Sankian Mojtaba , Soukhtanloo Mohammad
Published: April 2020

Allergy to non-specific lipidtransfer protein (nsLTP), the major allergen of grape (Vit v1), is considered as one of the most common fruit allergies in Iran. Therefore, a specific monoclonal antibody (mAb) can be used for the characterization and assessment of. Accordingly, this study aimed to generate and characterize a mAb against Vit v1 with a diagnostic purpose. To this end, Vit v1 allergen (9 kDa) was extracted using a modified Bjorksten extraction method. Natural Vit v1-immunized mouse splenocytes were fused with SP2/0Ag-14 myeloma cells for generating hybridoma cells. Specific antibody-secreting Hybridoma cells were selected using ELISA. Finally, anti-Vit v1 mAb was characterized by western blotting, ELISA, and isotyping methods. In the current study, a 9 kDa (Vit v1) protein was attained fromcrude and fresh juice of grape extracts and the isotype of desired anti-Vit v1 mAb was determined as IgM with k light chain. In addition, The ELISA results demonstrated that anti-Vit v1 mAb was specified against natural Vit v1 in the grape cultivar and related LTP allergens, such as Pla or 3 (p<0.0001). In the present study, a specific mAb was produced for detecting the LTP allergen. This mAb with a confirmed specificity can be utilized for evaluating the LTP allergens and their allergenicity in different grape cultivars.
Hernia diafragmática congénita: presentación de un caso y revisión de la literatura
Authors: Sepulveda Agudelo Janer , Becerra Mojica Carlos Hernán , Ariza Cadena Fredy , Acosta Puentes Diana M.
Published: April 2020

Presentamos el caso de una gestante de 14 años cuyo embarazo fue diagnosticado en el hospital San Juan de Dios de Vélez, Colombia. El producto presentó hernia diafragmática congénita; esta alteración ocurre con una frecuencia de 1 en 2 000 embarazos, por lo cual se hace una revisión detallada de la literatura de esta patología.
Interrupción quirúrgica de las vías nerviosas en el dolor pélvico crónico
Authors: Alba Velásquez María Cristina , Castro Cuenca Carlos Giovani
Published: April 2020

El dolor pélvico crónico es una patología muy común en la población femenina y constituye un reto para el médico que se enfrenta a este síndrome. En esta revisión pretendemos evaluar las indicaciones y utilidad de las diferentes técnicas de interrupción quirúrgica de las vías nerviosas provenientes de la pelvis femenina. Actualmente la técnica de ablación laparoscópica de los ligamentos uterosacros (LUNA) es la más utilizada de todas.
Empleo de metronidazol durante el primer trimestre de embarazo: revisión bibliográfica
Authors: Parrado Ralph
Published: April 2020

Antecedentes: el metronidazol se emplea en la paciente obstétrica cada día con mayor frecuencia debido a las complicaciones obstétricas asociadas a la vaginosis bacteriana y la tricomoniasis. Existen, sin embargo, médicos y mujeres que todavía dudan emplear el metronidazol, especialmente durante los primeros meses de embarazo por temor a posibles efectos teratogénicos.Objetivo: evaluar el riesgo de teratogenicidad del metronidazol durante el primer trimestre de embarazo.Método: revisión de la literatura actual sobre el empleo de metronidazol durante el primer trimestre de embarazo y sus efectos teratogénicos.Conclusiones: la administración de metronidazol durante el primer trimestre de embarazo no se relaciona clínicamente con un mayor riesgo de alteraciones congénitas.
Controversias en el manejo quirúrgico del endometrioma ovárico
Authors: Saavedra Jaime
Published: April 2020

La supresión hormonal del endometrioma ovárico mayor de 1 cm no es efectiva; sin embargo, tal supresión puede mejorar los síntomas en el 40% a 65% de los pacientes por un período de 6 a 12 meses. La aspiración de endometrioma ya sea transvaginal o transabdominal mediante la guía ultrasonográfica o por laparoscopía no es aconsejable como tratamiento quirúrgico de primera línea. Estos procedimientos están seguidos de una alta tasa de recurrencia (28% a 100%) dentro de 1 a 9 meses siguientes a la aspiración. La supresión hormonal antes o después de la aspiración no afecta el resultado. La vaporización laparoscópica de las paredes del quiste previa apertura de éste ya sea con láser o electrocauterio es mejor que el tratamiento de aspiración solo. La tasa de mejoría de los síntomas después del procedimiento es de 74% a 91%, la tasa de recurrencia es de 8% a 13% con una tasa de embarazo del 45% al 50%.El tratamiento laparoscópico del endometrioma ovárico por extirpación de la pared del quiste parece ser el mejor tratamiento quirúrgico. Este procedimiento es técnicamente más difícil que la vaporización de la pared del quiste, pero se asocia con una mejoría prolongada de la sintomatología, baja recurrencia del dolor pélvico, y bajas tasas de reoperación. Las tasas acumulativas de embarazo son más altas que después de vaporización. Los estudios actuales concluyen primero, que la vaporización de la pared interna del endometrioma no daña la función ovárica en términos de los parámetros de FIV y resultados; segundo, que los riesgos teóricos de pérdida de tejido ovárico viable durante la cistectomía existen pero se puede evitar con una técnica microquirúrgica laparoscópica, teniendo el cuidado de preservar la corteza ovárica residual normal; y tercero, los resultados de FIV después de extirpar o destruir los endometriomas en los pacientes con endometriosis son similares cuando se comparan con mujeres con factor tubárico o infertilidad idiopática.
Incidencia y aspectos clínicos relacionados con la eclampsia, en el Hospital de Maternidad "Rafael Calvo", Cartagena, Colombia. 1995-2001
Authors: Monterrosa Castro Álvaro , Bello Trujillo Ana María
Published: April 2020

La eclampsia es una de las patologías que más genera riesgos para la paciente obstétrica. El presente estudio tiene como objetivo identificar las características clínicas y epidemiológicas asociadas con el estado materno complicado con eclampsia. Es un estudio observacional, descriptivo de casos de pacientes con diagnóstico de eclampsia que consultaron al Hospital de Maternidad "Rafael Calvo" en Cartagena, Colombia entre el primero de enero de 1995 y el 31 de junio de 2001. Se atendió un total de 73.947 partos de los cuales 188 (0,25%) fueron pacientes que presentaban eclampsia, lo que representa un caso por cada 393 partos. La mayoría de las pacientes (58%) eran adolescentes, 64% eran primigestantes; 53% de los embarazos fueron a término y 45% de las mujeres no tenía control prenatal. Se presenta la correlación entre el número de convulsiones con la edad de la paciente y con la edad gestacional. Un mayor número de pacientes con eclampsia (86%) presentó convulsiones antes del parto, y 89% se desembarazaron en un lapso menor de 12 horas a partir de su ingreso al hospital. Se presentaron complicaciones en 14% de las pacientes, y las más frecuentes fueron: síndrome HELLP (7%) y desprendimiento prematuro de placenta normalmente inserta (3.1%). La incidencia de mortalidad fue de 2,2%, y la eclampsia fue responsable de 16% de todas las muertes maternas.La eclampsia se puede prevenir en un alto porcentaje de casos y ello se consigue con un buen control prenatal, que identifique al grupo con factores de riesgo, y minimizando los efectos deletéreos que causa la hipertensión inducida por el embarazo. El estudio permite evidenciar el manejo pronto e intervencionista - desde el punto de vista de finalización de la gestación - que se está adelantando en este centro en el manejo de la eclampsia, y coloca en evidencia las grandes deficiencias que todavía existen en cuanto a control prenatal.
Editorial
Authors: De Castro Dangond Jorge Fernández
Published: April 2020

La nueva Junta Directiva de la Sociedad Colombiana de Obstetricia y Ginecología hace llegar su más cordial saludo a todos sus socios e invita a vincularse a todos aquellos ginecólogos que se encuentren por fuera de ella.

Esta Junta Directiva fue elegida el pasado 19 de abril en la Asamblea General Ordinaria que tradicionalmente se realiza junto con nuestro Congreso Nacional. A ella asistieron las 21 Sociedades filiales y los nueve miembros de la Junta Directiva. De estos treinta votos presentes participaron veinticinco, conformando así el quórum estatutario. De esta manera hemos recibido el honroso encargo de dirigir el rumbo de nuestro gremio durante los dos próximos años. Sea la ocasión para expresar nuestros profundos agradecimientos a quienes nos depositaron su confianza con su voto.
Virginia Apgar y la anestesiología obstétrica: aportes, anécdotas y aficiones
Authors: Jácome Roca Alfredo
Published: April 2020

En el 2002 estamos recordando los cincuenta años de la presentación del estudio sobre el popular puntaje Apgar, realizada en el 27° Congreso Anual de Anestesistas, reunión conjunta de la Sociedad Internacional de Investigación en Anestesia y el Colegio Internacional de Anestesistas, en septiembre de 1952, en Virginia Beach; este análisis sencillo de un sistema fácil y expedito de valorar a un recién nacido, ha resultado de extraordinaria utilidad para anestesiólogos, ginecoobstetras y pediatras neonatólogos (1).
Levels of Students with Intellectual Disability in Associating Natural and Artificial Sounds to their Sources
Authors: DEMİRCİOĞLU Gökhan , KAVGACI Gonca
Published: April 2020

The aim of this study is to determine levels of students with intellectual disability in associating natural and artificial sounds to their sources. In this study, case study method was used. The study sample consisted of a total of 15 students with intellectual disability selected from two secondary schools, one preschool and one special education school. In the study, a total of 17 pictorial cards illustrating 6 animals, 6 musical instruments and 5 environmental events, and the sounds related to the images on each card were used to collect data. In the process of implementation, each student was first given the pictorial cards and a sound belonging to one of the images on the cards was played. The student was asked to show the image to which the sound belonged and then to say the name of the image. This procedure was performed similarly for all the cards. The study results showed that students with intellectual disability better perceive and discriminate the sounds they encounter in daily life, but they have difficulty in identifying the sounds not encountered in daily life. Besides, it was determined that some students have difficulty in pronouncing the sounds.
A imagem e seus sentidos imanentes e transcendentes
Authors: Anaz Sílvio Antonio Luiz
Published: April 2020

Este artigo busca contribuir na compreensão da natureza da imagem e de seu papel na geração de sentidos nos processos comunicacionais. Baseada principalmente nas perspectivas teóricas de Durand (2002), Jung (1994, 2011) e Damásio (2004, 2011), a reflexão explora como se dá a construção da imagem simbólica, a partir do papel dos arquétipos e das capacidades de percepção e de imaginação humanas, e de que forma esse tipo de imagem constrói os significados que produz. Como resultado, propõe-se um conceito de imagem que a coloca como elemento básico e essencial do pensamento humano que antecede ontológica e temporalmente a palavra e é dotada de significações imanentes e transcendentes.
Telejornalismo: estratégias de reconfiguração de uma mesma notícia
Authors: Backes Vanessa Cristina , Duarte Elizabeth Bastos
Published: April 2020

Ao longo do dia, diferentes telejornais da TV Globo veiculam, de maneira muitas vezes insistente e exaustiva, notícias sobre os mesmos acontecimentos. Ora, para uma audiência assídua, essa repetição de assuntos, o dia inteiro, pode ter sua necessidade questionada, além de se tornar bastante cansativa. Dessa maneira, o presente trabalho propõe-se a examinar o processo de reconfiguração de notícias sobre os mesmos acontecimentos, veiculadas em cinco telejornais da TV Globo ao longo de 24 horas. Interessa, particularmente, a análise do modo de operação dos dispositivos discursivos de tematização, figurativização, actorialização, espacialização, temporalização e tonalização no processo de conformação das notícias sobre dois diferentes acontecimentos, veiculadas em cinco telejornais – Hora 1 da Notícia, Bom Dia Brasil, Jornal Hoje, Jornal Nacional e Jornal da Globo – no período de 24 horas. Compete verificar como ocorre a manipulação dos dispositivos discursivos que conferem sentido de atualidade aos temas veiculados reiteradamente. A organização teórico-metodológica fundamenta-se em uma semiótica discursiva de inspiração europeia baseada em Saussure (2012), Hjelmslev (2013) e Greimas e Courtés (2016). Além disso, a investigação engloba autores que tratam, especificamente, da produção televisual. Os resultados obtidos revelam a existência de, pelo menos, três processos de reconfiguração dos elementos discursivos na conformação de notícias sobre os mesmos acontecimentos: (1) complexificação dos dipositivos discursivos; (2) estabilização dos dispositivos discursivos e (3) reprise/reapresentação das mesmas conformações discursivas, demonstrando uma rotina de produção jornalística baseada no reaproveitamento de materiais captados que são reutilizados para compor as narrativas sobre determinados acontecimentos.
Priori Incantatem: uma discussão sobre a colonização do imaginário no larp blockbuster
Authors: Miklos Jorge , Iuama Tadeu Rodrigues
Published: April 2020

O presente artigo tem por tema a relação do larp com os Estudos do Imaginário, sobretudo naqueles que têm recebido maior cobertura midiática, que podem ser chamados de larps blockbusters. A partir desse recorte, é discutida uma potencial colonização do Imaginário pela cooptação mercadológica dessa mídia. Para tanto, utiliza-se, sobretudo, os conceitos de mediosfera, vínculos hipnógenos e o potencial transcendente da comunicação por meio de uma revisão bibliográfica que dialoga com estudo de caso.
Pengaruh Vitamin C terhadap Fragilitas Osmotik Eritrosit pada Mahasiswa Kedokteran Universitas Jember yang Mengalami Stres Psikologis
Authors: Muslim Zulfahmi , Prasetyo Aris , Wahyudi Septa Surya
Published: April 2020

Medical students are constantly getting stress that could lead to oxidative stress where the level of free radicals is higher than the level of antioxidants in the body. Free radicals can bind to erythrocyte membranes and alter membrane structure that lead to the integrity of the erythrocyte membrane resulting in decreased erythrocyte ability in preventing hemolysis. Vitamin C is an antioxidant that could prevent free radicals bond to erythrocyte membrane. Vitamin C works by donating electrons to free radicals and prevent binding to erythrocyte membranes. The purposed of this study was to determine the effect of vitamin C consumption on osmotic fragility of erythrocytes in medical students with psychological stress. This research was clinical trial research with quasi experimental with pretest-posttest control group design. Researchers used Depression Anxiety Stress Scale (DASS) questionnaire to measure the stress level. Data analysis using T test obtained mean of percentage of hemolysis between pretest and posttest was   p= 0,02. It can be concluded that there is significant difference on osmotic fragility due to Vitamin C consumption in medical Student of Jember University with psychological stress.
Fisioterapia en tiempos de COVID-19
Authors: Condezo Casasola Giuliana
Published: April 2020

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IMPACT OF TRADE CREATION AND TRADE DIVERSION IN ASEAN-JAPAN COMPREHENSIVE ECONOMIC PARTNERSHIP (AJCEP)
Authors: Aprilia Gayatri Talita , Handoyo Rossanto Dwi
Published: April 2020

This study uses a gravity model to analyze the impact of the ASEAN-JAPAN COMPREHENSIVE ECONOMIC PARTNERSHIP (AJCEP) agreement on total Indonesian exports and to analyze the occurrence of trade creation or trade diversion. The data used in this study is panel data, the time used in this study from 2000 to 2015 consisting of 16 countries. This result finds the coefficient value of the FTA dummy of 0.207. This positive relationship indicates that there is a trade creation in AJCEP member countries and non AJCEP members. So it indicates that the welfare of member states and non AJCEP members. Total GDP, real exchange rate is positively correlated and GDP per capita difference and distance are negatively related to total Indonesian exports.Keywords: ASEAN-Japan Comprehensive Economic Partnership, Gravity Model, Trade Creation and Trade Diversion.
ANALISIS PENGARUH FLY ASH DAN KAPUR TOHOR PADA NETRALISASI AIR SKALA LABORATORIUM DI PT JORONG BARUTAMA GRESTON
Authors: Jannah Noor Wahidatul , Triantoro Agus , Riswan Riswan
Published: April 2020

Air asam tambang sering menjadi masalah yang besar dalam setiap pertambangan karena sangat berdampat negatif bagi lingkungan di wilayah tambang tersebut. Oleh sebab itu, untuk mengatasi air asam dilakukanlah proses penetralan secara aktif terhadap air asam. Material yang digunakan dalam proses penetralan menggunakan fly ash dan kapur tohor karena kedua material mengandung CaO.Pada penelitian ini, proses netralisasi dilakukan dalam skala laboratorium dimana air asam tambang diambil dari void M23_C. Dari hasil penelitian, hasil uji coba fly ash untuk penetralan menunjukkan hasil yang positif yaitu dengan dosis 1,6 gr/l mampu menaikkan nilai pH dari pH 3 menjadi pH 7 dalam waktu 125 menit dengan penurunan logam Fe dari 0,52 mg/l menjadi 0,50 mg/l, penurunan logam Mn dari 5,3 mg/l menjadi 5,2 mg/l serta nilai TSS dari 9 mg/l menjadi 71 mg/l.Hasil uji coba penetralan menggunakan kapur ternyata lebih efektif dari fly ash yaitu dengan dosis 0,04 gr/l mampu menaikkan nilai pH dari pH 3 menjadi pH 7 dalam waktu 60 menit dengan penurunan logam Fe dari 0,52 mg/l menjadi 0,32 mg/l, penurunan logam Mn dari 5,3 mg/l menjadi 3,6 mg/l serta nilai TSS dari 9 mg/l menjadi 10 mg/l.  Kata-kata kunci: Air asam tambang, fly ash, kapur tohor, pH, Fe, Mn, TSS.