bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing a model for predicting safety performance of nurses based on psychosocial safety climate and role of job demands and resources, job satisfaction, and emotional exhaustion as mediators
Authors: Abdi Fatemeh , Jahangiri Mehdi , Kamalinia Mojtaba , Cousins Rosanna , Mokarami Hamidreza
Published: June 2023

Background

The present study aimed to develop a model for predicting the safety performance of nurses based on psychosocial safety climate (PSC) and the role of job demands and resources, job satisfaction, and emotional exhaustion as mediators.

Methods

A cross-sectional study using structural equation modeling (SEM) was carried out among nurses in Iran. Data were collected using the Psychosocial Safety Climate questionnaire, Neal and Griffin’s Safety Performance Scale, the Management Standards Indicator Tool, the Effort-Reward Imbalance questionnaire, the Michigan Organizational Assessment Job Satisfaction subscale and the Maslach Burnout Inventory.

Results

Surveys were distributed to 340 nurses provided informed consent. After removing incplete surveys, data from 280 partipants were analysed. The completion rate was 82.35%. The SEM results indicated that PSC can directly and indirectly predict nurses’ safety performance. The final model showed an acceptable goodness of fit (p = 0.023). It indicated that PSC, job demands, and job satisfaction were directly related to safety performance, and also that PSC, emotional exhaustion, job resources, and job demands were all indirectly related to safety performance. Also, PSC had a significant relationship with all mediator variables, and job demands had direct effect on emotional exhaustion.

Conclusions

The current study presented a new model for predicting safety performance in nurses in which PSC, both directly and indirectly, plays an important role. In addition to paying attention to the physical aspects of the workplace, healthcare organizations should also take into account PSC to improve safety. Next steps in reducing safety issues in nursing is to develop intervention studies using this new evidence-based model as a framework.
Post_production. architectural design and the landscape of de-industrialisation
Authors: Spanedda Francesco
Published: June 2023

Industrial facilities have been dispersed across the American and European landscapes since the early Nineteenth century. Also, their activity encouraged the growth of a vast global network of logistical, mining, and agricultural infrastructures. Yet, since the late 1960s, a significant number of productive sectors have been gradually dismantled as a result of technical advancement, obsolescence, and changes in industrial regulations. The repurposing of “brownfields”, as abandoned industrial sites have been dubbed, became a topic of discussion in the architectural community. In the 1980s, this circumstance presented an amazing opportunity to modernise the layout of Western cities. Yet, contemporary critical views on the nature and effects of industrialism, societal transformations, and awareness of the environmental crisis at the turn of the Twentieth century call for refocusing the architectural discussion regarding brownfields. In this essay, case studies are examined and set against the backdrop of an expanding conversation in architecture regarding sustainability.
How well-intentioned white male physicists maintain ignorance of inequity and justify inaction
Authors: Dancy Melissa , Hodari Apriel K.
Published: June 2023

Background

We present an analysis of interviews with 27 self-identified progressive white-male physics faculty and graduate students discussing race and gender in physics. White cis men dominate most STEM fields and are particularly overrepresented in positions of status and influence (i.e., full professors, chairs, deans, etc.), positioning them as a potentially powerful demographic for enacting systemic reform. Despite their proclaimed outrage at and interest in addressing inequity, they frequently engage in patterns of belief, speech and (in)action that ultimately support the status quo of white male privilege in opposition to their intentions.

Results

The white male physicists we interviewed used numerous discourses which support racist and sexist norms and position them as powerless to disrupt their own privilege. We present and discuss three overarching themes, seen in our data, demonstrating how highly educated, well-intentioned people of privilege maintain their power and privilege despite their own intentions: (1) denying inequity is physically near them; (2) locating causes of inequity in large societal systems over which they have little influence; and (3) justifying inaction.

Conclusions

Despite being progressively minded and highly educated, these men are frequently complicit in racism and sexism. We end with recommendations for helping cis men engage the power they hold to better work with marginalized people to disrupt inequity.
Air gap eccentric analysis and fault detection of traction motor
Authors: Yin Jintian , He Zhilong , Liu Li , Peng Zhihua
Published: June 2023

To solve the problem of air gap eccentric fault of traction motor, the fault characteristic frequency is close to the fundamental frequency, and the decomposed frequency affects each other, which is easy to cause spectrum aliasing. A reconstruction of variational mode decomposition method is proposed (reconstructed variational mode decomposition, RVMD); first of all, to construct and solve the variational stator current signal problem, to find the best decomposition number, and to obtain multiple modal functions, and to realize the effective separation and frequency profile of each component of the signal. Then, the decomposed modal function components with different frequencies and different amplitude can keep the decomposed positions unchanged and be reconstructed to form a new frequency spectrum. Experimental results show that the proposed RVMD method can detect weak faults timely and effectively, and has good application value.
Shared sorrow, shared costs: cost-effectiveness analysis of the Empowerment group therapy approach to treat affective disorders in refugee populations
Authors: Strupf Michael , Hoell Andreas , Bajbouj Malek , Böge Kerem , Wiechers Maren , Karnouk Carine , Kamp-Becker Inge , Banaschewski Tobias , Meyer-Lindenberg Andreas , Rapp Michael , Hasan Alkomiet , Falkai Peter , Habel Ute , Heinz Andreas , Plener Paul , Kaiser Franziska , Weigold Stefanie , Mehran Nassim , Übleis Aline , Padberg Frank
Published: June 2023

Background

Refugees and asylum seekers (RAS) in Germany need tailored and resource-oriented mental healthcare interventions.

Aims

To evaluate the cost-effectiveness of group psychotherapy for RAS with moderate depressive symptoms.

Method

This is a post hoc cost-effectiveness analysis of Empowerment group psychotherapy that was embedded in a stratified stepped and collaborative care model (SCCM) from the multicentre randomised controlled MEHIRA trial. One hundred and forty-nine participants were randomly assigned to SCCM or treatment as usual (TAU) and underwent Empowerment (i.e. level 3 of the SCCM for adults) or TAU. Effects were measured with the nine-item Patient Health Questionnaire (PHQ-9) and quality adjusted life-years (QALY) post-intervention. Health service and intervention costs were measured. Incremental cost-effectiveness ratios (ICER) were estimated and net monetary benefit (NMB) regressions with 95% confidence intervals were performed. Cost-effectiveness was ascertained for different values of willingness to pay (WTP) using cost-effectiveness acceptability curves for probable scenarios. Trial registration number: NCT03109028 on ClinicalTrials.gov.

Results

Health service use costs were significantly lower for Empowerment than TAU after 1 year. Intervention costs were on average €409.6. Empowerment led to a significant change in PHQ-9 scores but not QALY. Bootstrapped mean ICER indicated cost-effectiveness according to PHQ-9 and varied considerably for QALY in the base case. NMB for a unit reduction in PHQ-9 score at WTP of €0 was €354.3 (€978.5 to −€269.9). Results were confirmed for different scenarios and varying WTP thresholds.

Conclusions

The Empowerment intervention was cost-effective in refugees with moderate depressive symptoms regarding the clinical outcome and led to a reduction in direct healthcare consumption. Concerning QALYs, there was a lack of confidence that Empowerment differed from TAU.
Operational Metrics for the ELAINE 2 Study Combining a Traditional Approach With a Just-in-TIME Model
Authors: Blau Sibel , Peguero Julio Antonio , Moore Halle C.F. , Anderson Ian Churchill , Barve Minal A. , Cherian Mathew Amprayil , Elkhanany Ahmed , O'Sullivan Ciara Catherine , Moreno-Aspitia Alvaro , Plourde Paul , Gleich Lyon L. , Riesen Kendra , Ezzati Ross , Degele Meghan , Shulman Megan , Stempf Stephanie Dobson , Sachse Laura , Iyer Amrita A. , Damodaran Senthil , Cooney Matthew M.
Published: June 2023

PURPOSE

There are numerous barriers to enrollment in oncology biomarker-driven studies.

METHODS

The ELAINE 2 study (ClinicalTrials.gov identifier: NCT04432454 ) is an open-label phase 2 study of lasofoxifene combined with abemaciclib in patients with advanced or metastatic estrogen receptor–positive/human epidermal growth factor receptor 2–negative breast cancer with an ESR1 mutation. ELAINE 2 opened clinical sites by using a Traditional approach, which activated a site before patient identification, and the Tempus TIME Trial network, which opened a site only after identifying an eligible patient. This manuscript presents the operational metrics comparing the Traditional and TIME Trial site data.

RESULTS

The study enrolled patients over 34 weeks and 16 sites (six Traditional and 10 TIME Trial) participated. Duration for full clinical trial agreement execution for Traditional sites and TIME Trial sites averaged 200.5 (range, 142-257) and 7.6 days (range, 2-14), respectively. Institutional review board approval time for Traditional sites and TIME Trial sites was 27.5 (range, 12-71) and 3.0 days (range, 1-12), respectively. Duration from study activation to first consent was 33.3 (range, 18-58) and 8.8 days (range, 1-35) for Traditional and TIME Trial sites, respectively. The first patient on study was at a TIME Trial site 115 days before a Traditional site and the first seven patients enrolled were at TIME Trial sites. Traditional sites consented 23 and enrolled 16 patients, while TIME Trial sites consented 16 and enrolled 13. The trial enrolled 29 patients in 8.5 months with the anticipated enrollment duration being 12-18 months.

CONCLUSION

The TIME Trial network opened earlier and enrolled the first study patients. These results demonstrate that the Just-in-TIME model, along with a Traditional model, can improve enrollment in biomarker-driven studies.
Circulating Inflammatory Cytokines and Female Reproductive Diseases: A Mendelian Randomization Analysis
Authors: Lin Yiting , Wang Guiquan , Li Yan , Yang Haiyan , Zhao Yue , Liu Jun , Mu Liangshan
Published: June 2023

Context

Extensive studies have provided considerable evidence suggesting the role of inflammation in the development of female reproductive diseases. However, causality has not been established.

Objective

To explore whether genetically determined circulating levels of cytokines are causally associated with female reproductive diseases and discover potential novel drug targets for these diseases.

Methods

Instrumental variables (IVs) for 47 circulating cytokines were obtained from a genome-wide association study (GWAS) meta-analysis of 31 112 European individuals. Protein quantitative trait loci and expression quantitative trait loci close to genes served as our IVs. Summary data of 9 female reproductive diseases were mainly derived from GWAS meta-analysis of the UK biobank and FinnGen. We elevated the association using the Wald ratio or inverse variance–weighted Mendelian randomization (MR) with subsequent assessments for MR assumptions in several sensitivity and colocalization analyses. We consider a false discovery rate <0.05 as statistical significance in MR analyses. Replication studies were conducted for further validation, and phenome-wide association studies were designed to explore potential side effects.

Results

Our results indicated that high levels of macrophage colony-stimulating factor (MCSF), growth-regulated oncogene-alpha (GROα), and soluble intercellular adhesion molecule-1 were associated with increased risks of endometriosis, female infertility, and pre-eclampsia, respectively. High platelet-derived growth factor-BB (PDGF-BB) levels that reduced the risk of ovarian aging were also supported. Replication analysis supported the relationship between GROα and female infertility, and between MCSF and endometriosis.

Conclusion

We identified 4 correlated pairs that implied potential protein drug targets. Notably, we preferred highlighting the value of PDGF-BB as a drug target for ovarian aging, and MCSF as a drug target for endometriosis.
“She Whistles Freely Shunning Companions”: The Embedded and Transcendent Selves of Poet-Painter Wang Liang in the Eighteenth Century
Authors: Theiss Janet
Published: June 2023

This article examines the unusual life of the poet and painter Wang Liang (ca. 1720–1790). Granddaughter of a prominent Jiaxing bibliophile and collector, she lost her father in infancy and married into a respected Huzhou family of officials only to witness their demise amidst a very public sex and corruption scandal in 1740, which also implicated her own wealthy merchant family. In the wake of this disaster, she and her husband severed their family ties and lived out their years in genteel poverty, childless. Surviving her husband by over twenty-five years, she fashioned an independent life and a self-image, echoed by observers, of Daoist detachment from the proverbial dust of the world while cultivating relationships with prominent male mentors and female artists across Jiangnan. As poet, painter, and player of the zither and the game of Go, Wang Liang at times articulated a vision of explicitly ungendered artistic perfection resembling aspects of the androgynous ideal associated with the culture of the Ming-Qing transition. Yet she was also poignantly aware that she was still embedded in relationships that pulled her back into family obligation, gendered hierarchy, and social exchange. I delve into her extant poetry and commentary about her to present her life and art as a contrapuntal play between embedded and transcendent modes of identity and expression.
From Convention to Subversion: Case Studies on the Female Gaze in Premodern China
Authors: Fong Grace S.
Published: June 2023

This article engages the ekphrastic mode—the literary representation of visual representation—to examine the female gaze instantiated in women's poetry on paintings of beautiful women in the Ming and Qing periods. Through four case studies, it shows how women poets and painters participated in the visual culture of late imperial China and negotiated gendered difference in their aesthetic vision and artistic production.
Variable body and tissue weight reporting in preclinical cachexia literature may alter study outcomes and interpretation
Authors: Beaudry Anna G. , Law Michelle L.
Published: June 2023

Cancer cachexia is a multifactorial syndrome of body weight loss, muscle wasting and progressive functional decline, affecting many advanced cancer patients and leading to worsened clinical outcomes. Despite inherent limitations of many preclinical cachexia models, including large tumor burden, rapid tumor growth and young age of animals, these animal models are widely used and imperative for the study of cachexia mechanisms and experimental therapeutics. However, there are currently no guidelines for the reporting and representation of data in preclinical cachexia literature. We examined the current state of data reporting in publications using the colon-26 adenocarcinoma (C26) model of cachexia and compared statistical differences in reporting mechanisms using animals from our laboratory. We show that data reporting and representation in C26 preclinical cachexia literature are diverse, making comparison of study outcomes difficult. Further, different expression of body and tissue weights in our animals led to differential statistical significance, which could significantly alter data interpretation. This study highlights a need for consistent data reporting in preclinical cancer cachexia literature to effectively compare outcomes between studies and increase translatability to the human condition.
Özlem İlyas, Freelance Emek: Ofissiz Çalışmanın Sınıfsallığı, İletişim Yayınları, 2022, 216 s.
Authors: Kaşık Elif
Published: June 2023

Bu yazı Özlem İlyas'ın Freelance Emek: Ofissiz Çalışmanın Sınıfsallığı eserinin değerlendirmesini içermektedir.
Lübnan Düşüncesinin Oluşumunda Beyrut’taki Misyoner Okullarının Katkısı
Authors: Danış Mehmet Fahri , Danacıoğlu Esra
Published: June 2023

I. Dünya Savaşı sonrası Ortadoğu’da Avrupalı devletlerin manda idareleri altında kurulan yeni ulus-devletler, kendi özgün mevcudiyetlerini temellendirmek ve meşrulaştırmak amacıyla genellikle milli topluluklarının kökenlerini antik “atalar” ile irtibatlandırırlar. Bu irtibatlandırma süreçlerinde kullanılan “kurucu mit”ler, ulus-devletlerin teritoryal karakterlerini diğer kimliklerden ayrıştırma ve söz konusu ulus-devletlerin orijinal varlıklarını güçlendirme işlevini görürler. Lübnan düşüncesi de tam olarak böyle bir “kurucu mit” etrafında anlam kazanır ve modern Lübnan devletinin var oluş amacı, Lübnan’ın çevresindeki Arap-İslam karakterinden azade olup Fenikelilik temelinde istisnai bir kültüre sahip olması çerçevesinde okunur. Lübnan’ın Fenike ile eşleştirilmesi üzerinden sahip olduğu bu istisnai karakterin oluşumunda en etkili aktörlerden başlıcaları ise Beyrut’taki misyonerlerdir. Cizvitlere ait St. Joseph Üniversitesi ile Amerikalı Protestanlara ait Suriye Protestan Koleji (sonraki adıyla Beyrut Amerikan Üniversitesi), bu bağlamda bölgedeki en etkili eğitim kurumlarıdır. Bu çalışmada, 19. yüzyılın ikinci yarısıyla Lübnan’ın kurulduğu 1920 tarihleri arasında Bilâdüşşam’da bulunan Cizvit ve Protestan misyonerlerin, Lübnan’ın kurucu Fenike mitine ve bu vesileyle de Lübnan fikrine katkıları üzerinde durulacaktır.
Eşitsizlikler Tüketilebilir mi? Yoksulluğun Ticarileşmesi Olarak Getto Turizmi
Authors: Öztürk Özgür
Published: June 2023

Bu çalışmada kentsel ayrışmanın keskin bir biçimi olan gecekondu mahallelerindeki yoksulluk, dışlanmışlık ve marjinallik görünümlerinin turizm faaliyeti içerisine dahil edildiği getto turizmi ele alınmaktadır. Niş bir turizm türü olarak tanımlanan gecekondu turizmi, dünyanın en büyük gettolarının bulunduğu Rio de Janerio, Cape Town ve Mumbai’de hizmet veren tur firmalarının (Daytours4u, African Trails ve Reality Tours & Travel) web sitelerindeki tanıtım metinlerinin söylem analizi üzerinden tartışılmaktadır. Getto turizminin toplumsal faydalarına gönderme yapan bu firmaların söylemleri birbirleriyle ilişkili “otantik tüketim, farkındalık ve bölgesel kalkınma” temaları altında analiz edilmektedir. Otantik tüketim söylemi turistlere eşsiz deneyim vaadi sunarken, gettolardaki yoksulluğu deneyimlemenin ve kültürler arası etkileşimin bir farkındalık oluşturması beklenmektedir. Farkındalığın gettolara dair küresel medyadaki sterotiplerle mücadele edilmesi, yardımseverliğin ve bölgedeki ticari hareketliliğin artması ve STK’ların desteklenmesi üzerinden gettolarda ekonomik ve kültürel kalkınmayı sağlayacağı varsayılmaktadır. Bu ilişkisel temalar ise getto turizmini fırsat olarak gören ve bu turları “alternatif turlar”, “gerçeklik turları”, “otantik turlar” olarak ele alan yaklaşımlar ve onu “sosyal röntgencilik”, “yoksulluğun ticarileştirilmesi” noktalarından hareketle “yoksulluk turizmi”, “kara turizm”, “safari turları” olarak ele alan eleştirel yaklaşımların yer aldığı literatürden ve diğer kaynaklardan hareketle tartışılmaktadır.
Effect of intraoperative PEEP with recruitment maneuvers on the occurrence of postoperative pulmonary complications during general anesthesia––protocol for Bayesian analysis of three randomized clinical trials of intraoperative ventilation
Authors: Mazzinari Guido , Zampieri Fernando G. , Ball Lorenzo , Campos Niklas S. , Bluth Thomas , Hemmes Sabrine N.T. , Ferrando Carlos , Librero Julian , Soro Marina , Pelosi Paolo , Gama de Abreu Marcelo , Schultz Marcus J. , Serpa Neto Ary ,   PROVHILO investigators,   iPROVE investigators,   PROBESE investigators,   PROVE network investigators
Published: June 2023

Background: Using the frequentist approach, a recent meta–analysis of three randomized clinical trials in patients undergoing intraoperative ventilation during general anesthesia for major surgery failed to show the benefit of ventilation that uses high positive end–expiratory pressure with recruitment maneuvers when compared to ventilation that uses low positive end–expiratory pressure without recruitment maneuvers.

Methods: We designed a protocol for a Bayesian analysis using the pooled dataset. The multilevel Bayesian logistic model will use the individual patient data. Prior distributions will be prespecified to represent a varying level of skepticism for the effect estimate. The primary endpoint will be a composite of postoperative pulmonary complications (PPC) within the first seven postoperative days, which reflects the primary endpoint of the original studies. We preset a range of practical equivalence to assess the futility of the intervention with an interval of odds ratio (OR) between 0.9 and 1.1 and assess how much of the 95% of highest density interval (HDI) falls between the region of practical equivalence.

Ethics and dissemination: The used data derive from approved studies that were published in recent years. The findings of this current analysis will be reported in a new manuscript, drafted by the writing committee on behalf of the three research groups. All investigators listed in the original trials will serve as collaborative authors.
Clinical equivalence of Trusynth fast® and Vicryl rapide® polyglactin 910 fast absorbing sutures on maternal morbidity experienced by women following episiotomy repair: a single-blind, randomized study
Authors: Hemalatha Devi Dongabanti , Bolanthakodi Chethana , D’Cunha Prema , Bheema Bai Mudiki , Kumar Moharana Ashok , TS Deepak
Published: June 2023

Background: Episiotomy procedure enlarges the vaginal outlet to facilitate childbirth. Polyglactin 910 fast-absorbing sutures are widely used for the repair of episiotomy because of their rapid absorption and less inflammatory response. This study was designed for subjective assessment of perineal pain post-episiotomy repair, with Trusynth Fast® and Vicryl Rapide® polyglactin 910 fast-absorbing sutures.

Method: This was a single-blind, randomized, prospective study conducted between January 7, 2021 and July 14, 2021 across two centers in India. Primiparous or multiparous women (18—40 years), who required episiotomy during vaginal delivery were included, and either Trusynth Fast® (n=47) or Vicryl Rapide® (n=49) suture was used for their episiotomy repair. The primary endpoint, perineal pain was assessed with visual analogue scale at all follow-up visits. The secondary endpoints, quantity of local anesthesia, number of sutures used, time to repair episiotomy, intraoperative suture handling, analgesics used, early and late wound complications, wound re-suturing, time to complete healing, presence of residual sutures, return to sexual activity, dyspareunia, and adverse events were also recorded.

Results: The study showed no significant difference in perineal pain between the two groups at any visit. A statistically significant difference (p<0.05) in total score of episiotomy healing scale on day 2 (0.13±0.34 versus 0.35±0.56) and swelling on day 2 (8.51 versusversus 28.57%) was noted between Trusynth Fast® and Vicryl Rapide® group. Non-significant difference was observed between the groups regarding anesthesia, number of sutures, time to repair episiotomy, intraoperative suture handling, analgesics, puerperal fever, wound infection, dehiscence, hematoma, urinary incontinence, re-suturing, time to complete healing, return to sexual activity and dyspareunia.

Conclusion: Trusynth Fast® suture is clinically equivalent to Vicryl Rapide® suture and can be used for episiotomy repair with minimal risk of perineal pain and wound complications.

Clinical Trials Registry of India Registration: CTRI/2020/12/029925; Registered on December 18, 2020
Current trends, barriers, and facilitators of use of core outcome sets in Cochrane systematic reviews: Protocol
Authors: Saldanha Ian , Hughes Karen , Dodd Susanna , Lasserson Toby , Kirkham Jamie , Lucas Samuel , Williamson Paula
Published: June 2023

Background: Core outcome sets (COS) represent agreed-upon minimum outcomes that should be reported in all studies in a given topic area. Cochrane reviews are considered among the most rigorously conducted systematic reviews (SRs). In 2019, seven of the first 100 published Cochrane SRs (7%) cited a COS in relation to choosing outcomes. A relevant COS existed but was not mentioned (or cited) for 27 of the remaining 93 SRs (29%). Among Cochrane Review Group editors surveyed in 2019, 86% felt that COS should definitely/possibly be used in Cochrane SRs. As of September 2019, the Cochrane Handbook recommends that SR teams consult resources that host relevant COS when choosing outcomes for the SR.

Objectives: (1) Examine the extent to which authors are currently considering COS to inform outcome choice in Cochrane protocols and completed SRs. (2) Understand author barriers and facilitators of using COS in Cochrane protocols and completed SRs.

Methods: We will examine the extent to which all Cochrane SRs published in the last 3 months of 2022 and all Cochrane protocols published in 2022: (a) cited a COS, (b) searched for COS, and (c) reported outcome inconsistency among included studies and/or noted the need for COS. One investigator will extract information from SRs and protocols; a second extractor will verify all information, discussing discrepancies to achieve consensus. Using Jisc Online Surveys®, we will conduct an online anonymous survey of authors of all the included completed SRs and protocols to assess author awareness of COS and identify barriers and facilitators of using COS to inform outcome choice.

Discussion: This study will provide key information regarding uptake of COS by Cochrane SR authors and the barriers and facilitators that they experience. Our findings will inform approaches to increasing awareness and uptake of COS in future SRs, both with and beyond Cochrane.
Comparative study between therapeutic effects of microneedling versus CO2 laser in acne scars
Authors: Gupta Kunal , Maheshwari Pravin , Madke Bhushan
Published: June 2023

Objectives: To study the clinical aspect of acne scars while grading them on the basis of severity as well as to study and compare the therapeutic effects of CO2 laser and microneedling in their management.

Methods: This study used prospective comparison as its method of study. Over the course of two years, from June 2021 to June 2023, 100 patients above 18 years of age having post-acne atrophic scars will be enrolled. Patients will be split into two groups and each group will be selected for fractional CO2 laser (non-ablative) and microneedling respectively. Four treatments will be administered to each group of patients with a four-week gap between each session. All clinical findings will be recorded for data analysis and comparision. “Goodman and Baron’s Qualitative and Quantitative grading system for scars” will be used after each session in order to compare the therapeutic effects for each group.

Results: At the end of each session, acne scar grading will be done in each group and data will be compiled to assess and compare the therapeutic effects between CO2 laser and microneedling.

Conclusions: The findings of the protocol research will be used to form the conclusions.

Trial Registration: Submitted for registration to Clinical Trial Registry of India (CTRI).
Case Report: Transient complete blindness after coronary angiography
Authors: Alnazeer Moez , Kher Sapna , Ficklen David
Published: June 2023

Transient cortical blindness is a rare complication that can occur after coronary angiography. We report a case of a 53-year-old Caucasian male with a history of multiple cardiovascular risk factors who presented to the emergency room with chest pressure and shortness of breath. He underwent cardiac catheterization and subsequently developed transient bilateral blindness. His vision gradually improved over the next 72 hours without any intervention. This case highlights the importance of considering transient cortical blindness as a potential complication of coronary angiography and the favorable outcome of this condition.
The genome sequence of a tachinid fly, Nowickia ferox (Panzer, 1809)
Authors: Falk Steven , Raper Chris ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: June 2023

We present a genome assembly from an individual femaleNowickia ferox(a tachinid fly; Arthropoda; Insecta; Diptera; Tachinidae). The genome sequence is 670.7 megabases in span. Most of the assembly is scaffolded into 6 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 17.19 kilobases in length. Gene annotation of this assembly on Ensembl identified 27,893 protein coding genes.
The genome sequence of the Velvet Shank, Flammulina velutipes (Curtis) Singer, 1951
Authors: Wright Richard , Woof Kieran ,   Royal Botanic Gardens Kew Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: June 2023

We present a genome assembly from a specimen of Flammulina velutipes (the Velvet Shank; Basidiomycota; Agaricomycetes; Agaricales; Physalacriaceae). The genome sequence is 37.4 megabases in span. Most of the assembly is scaffolded into 12 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 79.6 kilobases in length.
Experiencia de estudiantes de medicina en un programa universitario de salud familiar y comunitaria de Bogotá (Colombia)
Authors: Rodríguez-Gómez Rodolfo , Platarrueda-Vanegas Claudia Patricia , Córdoba-González Yixel
Published: June 2023

Introducción: el estudio se desarrolló en el contexto de un programa de salud familiar y comunitaria de una universidad de Bogotá (Colombia), del cual participan los estudiantes de Medicina. El objetivo fue comprender los significados y sentidos que los estudiantes otorgan a la práctica de salud familiar y comunitaria en el sector de El Codito, ubicado en la localidad de Usaquén al nororiente de Bogotá. Materiales y métodos: la investigación es un estudio cualitativo de tipo fenomenológico. Se realizaron ocho entrevistas semiestructuradas a estudiantes de medicina pertenecientes a un programa universitario de salud familiar y comunitaria en Bogotá. Resultados: del proceso de análisis emergieron cuatro categorías: a) realidad y territorio; b) institucionalidad y salud familiar y comunitaria; c) agencia y proyección profesional, y d) comunicación, escucha y reconocimiento del otro. Se evidenciaron narrativas embebidas de experiencias significativas, dificultades y retos. Se destaca el rol participativo del estudiante en la interacción y comunicación con la familia. Conclusiones: la experiencia da cuenta de un proceso dinámico de donde emergen vivencias que confrontan a los estudiantes. Esta experiencia refleja aprendizajes y desafíos de carácter multidimensional, en especial por la vulnerabilidad del sector. De dicho proceso surge el reconocimiento de otras realidades, el autorreconocimiento y la proyección del estudiante como agente social y futuro profesional en medicina.
Countercyclical Risks, Consumption, and Portfolio Choice: Theory and Evidence
Authors: Shen Jialu
Published: June 2023

Using a quantitative, calibrated life-cycle model, I show that countercyclical earnings risk affects individual consumption growth, reduces the share of wealth in stocks, and affects savings behavior. Using the Panel Study of Income Dynamics survey, I construct an empirical measure of countercyclical earnings risk and find evidence consistent with the model’s predictions. Specifically, larger downside earnings risk decreases consumption growth, increases left skewness in consumption growth, and reduces the share of wealth in stocks. Furthermore, the consumption effects are substantially more significant for stockholders than for nonstockholders, which arises through heterogeneity in the elasticity of intertemporal substitution.

This paper was accepted by Tomasz Piskorski, finance.

Supplemental Material: The data and online appendix are available at https://doi.org/10.1287/mnsc.2023.4837 .
Finally Receiving Recognition
Authors: Grylls Bethan
Published: June 2023

FEMALE BRITISH ASTROPHYSICIST DONATES £2.3M AWARD AFTER BEING DISREGARDED BY NOBELS FOR PULSAR DISCOVERY
The Cutting Edge of Technology
Authors: Tyler Neil
Published: June 2023

The Cockcroft Institute is unique among institutions, bringing together industrialists, scientists and engineers to advance the science and technology supporting particle accelerators.
Multisystem Inflammatory Syndrome in Children: Tools for a Timely Diagnosis in the Emergency Department from an Italian Multicenter Survey
Authors: Mauro Angela , A Mauro , M Maglione , F Savoia , M Calvi , A Amoroso , M Sangerardi , B Tubino , E Piccotti , M Fabi , S Salvadei , D Gadda , F Marchetti , F Midullà , D Buonsenso , M Stanco , S Magrassi , F Salvini , R Pignataro , F Di Florio , E Del Giudice , L Bernardo , R Lubrano , V Tipo , M Rosa , T Gagliardi , L Picciano , S Gagliardi , F Orlando , I Bellani , V Canzaniga , F Medici , F La Torre , F Cardinale , J Tibaldi , B Schiappapietra , M D’Alessandro , M Bitelli , G Gallotta , S Masi , A Nucci , M Agosti , AM Plebani , A Iacono , F Cairello , C Ghizzi , N Rossi , I Schiavone , A Gentile
Published: June 2023

Objective: To assess the most frequent clinical features of Multisystem Inflammatory Syndrome in children (MIS-C) at presentation to the Emergency Department (ED) in a large multicenter cohort of patients, in order to define useful tools for a timely diagnosis. Methods: Clinical and laboratory characteristics were retrospectively reviewed for 210 MIS-C patients from 18 Italian pediatric EDs. We assessed correlations between clinical and laboratory parameters and compared features of patients of different age (≤5 years and >5 years). Results: Fever was the main presenting symptom (100%), followed by conjunctivitis (46%), abdominal pain (44%), vomiting (41%) and diarrhea (39%). Forty-nine percent of children presented to the ED in critical or nearly critical condition. A higher prevalence of mucocutaneous involvement was found in younger children (69% versus 47%, p<0.05), whereas gastrointestinal symptoms were more common in children >5 years (62% versus 85%, p<0.05). Higher values of inflammatory markers (C-Reactive Protein, Ferritin, and Fibrinogen), Troponin T and Brain Natriuretic Peptide were related to abnormal echocardiography (p<0.05). No significant differences were detected in laboratory parameters between the two age groups, apart from ferritin, fibrinogen and troponin T, which resulted significantly lower in children ≤5 years. Conclusions: Apart from fever, the most common MIS-C manifestations at presentation to the ED are conjunctivitis, abdominal pain, vomiting and diarrhea. Younger children more frequently present with mucocutaneous involvement, while gastrointestinal manifestations are more common in older patients. These findings should be considered when MIS-C is suspected in the ED, in order to achieve a timely recognition of the condition.
The ORthopaedic Trauma Hospital Outcomes - Patient Operative Delays (ORTHOPOD) study
Authors: Baldock Thomas E. , Walshaw Tom , Walker Reece , Wei Nicholas , Scott Sharon , Trompeter Alex J. , Eardley William G. P.
Published: June 2023

Aims

This is a multicentre, prospective assessment of a proportion of the overall orthopaedic trauma caseload of the UK. It investigates theatre capacity, cancellations, and time to surgery in a group of hospitals that is representative of the wider population. It identifies barriers to effective practice and will inform system improvements.

Methods

Data capture was by collaborative approach. Patients undergoing procedures from 22 August 2022 and operated on before 31 October 2022 were included. Arm one captured weekly caseload and theatre capacity. Arm two concerned patient and injury demographics, and time to surgery for specific injury groups.

Results

Data was available from 90 hospitals across 86 data access groups (70 in England, two in Wales, ten in Scotland, and four in Northern Ireland). After exclusions, 709 weeks' of data on theatre capacity and 23,138 operations were analyzed. The average number of cases per operating session was 1.73. Only 5.8% of all theatre sessions were dedicated day surgery sessions, despite 29% of general trauma patients being eligible for such pathways. In addition, 12.3% of patients experienced at least one cancellation. Delays to surgery were longest in Northern Ireland and shortest in England and Scotland. There was marked variance across all fracture types. Open fractures and fragility hip fractures, influenced by guidelines and performance renumeration, had short waits, and varied least. In all, nine hospitals had 40 or more patients waiting for surgery every week, while seven had less than five.

Conclusion

There is great variability in operative demand and list provision seen in this study of 90 UK hospitals. There is marked variation in nearly all injuries apart from those associated with performance monitoring. There is no evidence of local network level coordination of care for orthopaedic trauma patients. Day case operating and pathways of care are underused and are an important area for service improvement.

Cite this article: Bone Jt Open 2023;4(6):463–471.
BER performance of an FSOC system over atmospheric turbulence channels based on computational temporal ghost imaging
Authors: Huang Zhongqiang , Zhou Liyu , Huang Xianwei , Qin Hao , Zou Xuanpengfan , Fu Xiquan , Bai Yanfeng
Published: June 2023

In a free space optical communication (FSOC) system, atmospheric turbulence will increase the bit error ratio (BER) and impair FSOC link reliability. Since computational temporal ghost imaging (CTGI) has anti-interference, we present an FSOC system over atmospheric turbulence based on CTGI. The simulation results show that the BER performance of CTGI is better than on–off keying under different atmospheric turbulence regimes. To improve the performance of the CTGI scheme, the influence of the number of transmission samples and code length is analyzed. It is shown that BER performance improves with the increment of the number of samples, while code length has no impact. This scheme provides an idea for reliable communication over atmospheric turbulence and an important reference for improving wireless optical communication in an extreme environment.
Development of mixed pitch grating for the optical addressing of trapped Sr+ ion with data analysis techniques
Authors: Lim Yu Dian , Zhao Peng , Hu Liangxing , Guidoni Luca , Likforman Jean-Pierre , Tan Chuan Seng
Published: June 2023

Mixed pitch gratings are developed for the optical addressing of trapped 88Sr+ ion by means of simulation and experimental measurement approaches. Meanwhile, Python-based data analysis techniques were developed to analyze simulated and measured beam profiles. A fixed pitch grating with a pitch of 1.2 µm was used as a reference, and a mixed pitch grating with pitches of 1.1/1.2 µm of various ratios are investigated. The Python-based data analysis codes demonstrates highly automated capability in processing both simulated and measured beam profile data to compute key parameters, including beam waist and Gaussian fitting. Mixed pitch grating delivers light beam with smaller beam waist (17.4 µm) compared to the fixed pitch grating (26.4 µm), exhibiting ∼34% beam waist reduction.
Evolution between ferroelectric photovoltaic effect and resistance switching behavior engineered by the polarization field and barrier characteristics
Authors: Guo Fei , Liu Yaping , Liu Rui , Guo Siyuan , Xu Haojie , Li Yang , Yang Bo , Zhao Shifeng
Published: June 2023

The bandgap and polarization field play a key role in the ferroelectric photovoltaic effect. However, narrow bandgap induced electrical conductivity always brings out a depression of the photovoltaic performances. Based on the mechanisms of the photovoltaic effect and resistance switching behaviors in ferroelectric materials, this work realizes an evolution between the two effects by engineering the polarization field and barrier characteristics, which addresses the trade-off issues between the bandgap and polarization for ferroelectric photovoltaic effect. SrCoOx (SC, 2.5≤x≤3) with multivalent transition is introduced into Na0.5Bi0.5TiO3 (NBT) matrix material to engineered the polarization field and barrier characteristics. (1-x)NBT-xSC (x=0.03, 0.05, 0.07) solid solution films present an evolution of ferroelectric photovoltaic effect to grow out of nothing again to the disappearance of the photovoltaic effect and the appearance of resistance switching behavior. The 0.95NBT-0.05SC film achieve the open-circuit voltage of 0.81 V and the short-circuit current of 23.52 µA/cm2, and the 0.93NBT-0.07SC film obtains the resistive switching behavior with switch ratio of 100. This work provides a practicable strategy to achieve the fascinating evolution between photovoltaic effect and resistive switching.
Deep compression network for enhancing numerical reconstruction quality of full-complex holograms
Authors: Seo Juyeon , Lee Jaewoo , Lee Juhyun , Ko Hyunsuk
Published: June 2023

The field of digital holography has been significant developed in recent decades, however, the commercialization of digital holograms is still hindered by the issue of large data sizes. Due to the complex signal characteristics of digital holograms, which are of interferometric nature, traditional codecs are not able to provide satisfactory coding efficiency. Furthermore, in a typical coding scenario, the hologram is encoded and then decoded, leading to a numerical reconstruction via a light wave propagation model. While previous researches have mainly focused on the quality of the decoded hologram, it is the numerical reconstruction that is visible to the viewer, and thus, its quality must also be taken into consideration when designing a coding solution. In this study, the coding performances of existing compression standards, JPEG2000 and HEVC-Intra, are evaluated on a set of digital holograms, then the limitations of these standards are analyzed. Subsequently, we propose a deep learning-based compression network for full-complex holograms that demonstrates superior coding performance when compared to the latest standard codecs such as VVC and JPEG-XL, in addition to JPEG2000 and HEVC. The proposed network incorporates not only the quality of the decoded hologram, but also the quality of the numerical reconstruction as distortion costs for network training. The experimental results validate that the proposed network provides superior objective coding efficiency and better visual quality compared to the existing methods.
Multi-stable dye-doped dual-frequency twisted nematic liquid crystal smart window
Authors: Ma Chao , Bai Hao , Liang Yuge , Zhu Mengmeng , Zhu Jun , Qiu Longzhen , Lu Hongbo , Xu Miao
Published: June 2023

In this study, a novel, to the best of our knowledge, dye-doped dual-frequency liquid crystal multi-stable smart window is proposed. A chiral dopant with appropriate content was introduced into dye-doped dual-frequency liquid crystals to achieve an initial 180° twisted state. These liquid crystals can be switched to a nematic phase or a 360° twisted state by controlling the magnitude and frequency of the applied voltage. These nematic phase and 360° twisted states can exist stably for a long time because of the backflow effect and the anisotropic nature of the dual-frequency liquid crystal material. Due to the optical waveguide effect of dye-doped liquid crystals in the long-pitch state, the transmittance was different in nematic phase, 180°, and 360° twisted three zero-field stabilized absorption states. Finally, a multi-stable smart window is developed to switch between three zero-field stabilized absorption and scattering states.
Ultralow-quantum-defect single-frequency fiber laser
Authors: AlYahyaei Khawlah , Zhu Xiushan , Li Lizhu , Zong Jie , Li Maohe , Wang Junqin , Meyer Jason , Chavez-Pirson Arturo , Norwood Robert A. , Peyghambarian Nasser
Published: June 2023

A single-frequency distributed-Bragg-reflector fiber laser at 980 nm with a quantum defect of less than 0.6% was developed with a 1.5-cm 12 wt% ytterbium-doped phosphate fiber pumped by a 974.5-nm laser diode. Linearly polarized single-longitude-mode laser with a polarization extinction ratio (PER) of nearly 30 dB and spectral linewidth of less than 1.8 kHz was obtained. A maximum output power of 275 mW was measured at a launched pump power of 620 mW. The performance of the single-frequency fiber laser pumped at 909 nm and 976 nm was also characterized. This research demonstrated an approach to high-power single-frequency fiber laser oscillators with mitigated thermal effects.
Investigation of pure and hybrid tungsten-based transition metal di-chalcogenides for radiation resistant space photovoltaic applications
Authors: Roy Sayan , Bermel Peter
Published: June 2023

Transition metal di-chalcogenides (TMDCs) have strong potential for space photovoltaic applications since they are resilient to radiation, and hybrid alloys exhibit tunable electro-optic properties. The electronic properties of tungsten-based TMDC alloys containing sulfur, selenium and tellurium were calculated using density functional theory. Hybrid alloys have tunable direct bandgaps dependent on the chalcogen composition. A photovoltaic model consisting of pure and hybrid TMDCs was demonstrated to give an efficiency above 23% under the AM0 space solar spectrum. The non-ionizing energy loss due to high-energy radiation was investigated; it was shown that TMDCs have significantly enhanced radiation resilience than commonly used semiconductors.
Spectral responses of tilted fiber Bragg grating coated with a thin Ge2Sb2Se4Te1 layer
Authors: Ooi Cheong-Weng , Lim Kok-Sing , Ng Kuan-Huei , Chong Wu-Yi , Gan Soon-Xin , Goh Boon-Tong , Ahmad Harith
Published: June 2023

This article reports the spectral properties of a Ge2Sb2Se4Te1 (GSST) -coated tilted fiber Bragg grating to the changes of surrounding refractive index (SRI). The variations of the cladding mode resonance amplitudes and wavelengths under two orthogonal polarization modes are analyzed and validated with the simulation results. The introduction of the high index coating has induced non-degeneracy to the cladding modes, but the effect gradually diminishes with increasing SRI. The SRI sensitivities of the s-polarized modes have been substantially suppressed and became 20 times lower than that of p-polarized modes. The findings also reveal the association between the cladding resonance amplitudes, the imaginary part of the effective refractive indices and the evanescent field intensity distributions.