bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Lyapunov-based rapid and ripple-free MPPT using a robust model reference adaptive controller for solar PV system
Authors: Manna Saibal , Akella Ashok Kumar , Singh Deepak Kumar
Published: April 2023

The technological, economic, and environmental benefits of photovoltaic (PV) systems have led to their widespread adoption in recent years as a source of electricity generation. However, precisely identifying a PV system's maximum power point (MPP) under normal and shaded weather conditions is crucial to conserving the maximum generated power. One of the biggest concerns with a PV system is the existence of partial shading, which produces multiple peaks in the P–V characteristic curve. In these circumstances, classical maximum power point tracking (MPPT) approaches are prone to getting stuck on local peaks and failing to follow the global maximum power point (GMPP). To overcome such obstacles, a new Lyapunov-based Robust Model Reference Adaptive Controller (LRMRAC) is designed and implemented to reach GMPP rapidly and ripple-free. The proposed controller also achieves MPP accurately under slow, abrupt and rapid changes in radiation, temperature and load profile. Simulation and OPAL-RT real-time simulators in various scenarios are performed to verify the superiority of the proposed approach over the other state-of-the-art methods, i.e., ANFIS, INC, VSPO, and P&O. MPP and GMPP are accomplished in less than 3.8 ms and 10 ms, respectively. Based on the results presented, the LRMRAC controller appears to be a promising technique for MPPT in a PV system.
Contested Flights
Authors: Kavesh Muhammad A.
Published: April 2023

Despite the invention and sophistication of drones and unarmed aerial vehicles, satellites, and more recently, cyber espionage, “spy pigeons” remain a serious threat at the India-Pakistan border. The entanglement between flying pigeons for “sport” and capturing pigeons for “espionage” is critical to construe multiple meanings of more-than-human border intrusion in South Asia. Such an incursion not only endangers long-standing values of human-pigeon companionship but also moots a perplexity of intrusion that lies between the ethical acceptance of the more-than-human intruders and necessary resistance to their hostile infiltration. Explored through the geopolitically complex experiences of intrusion that have shaped the India-Pakistan relationship since Partition, intruding spy pigeons provide a critical perspective on distrust, animosity, and espionage in South Asia.
An Atomic Age Unleashed
Authors: Kramer Derek J.
Published: April 2023

While tens of thousands of Koreans were subject to the atomic attacks on Hiroshima and Nagasaki, early peninsular analysis of the bombings rarely grappled with the existence of these individuals. The general exclusion of colonial subjects from the story of the atomic bombings has long been identified as part of a nationalization of the wartime years, a move that situates the history of the attacks as a specifically Japanese experience. Less understood is how postcolonial intellectuals in Korea encouraged this historiographical trend. Across the peninsula, a common commitment to the idea of science as emancipatory enabled postcolonial Korean writers to conflate political liberation with advancements in the field of atomic science. This fusion of postcolonial developmentalism and atomic scientism, common in both the North and the South between 1945 and 1950, drowned out the critical temporalities introduced by peninsular survivors of the atomic attacks. This article outlines the historiographical obstacles Korean bomb victims posed to emancipatory accounts of the attacks. Postcolonial bomb victims were interpolated into a postwar community that was physiologically unable to leave the fact of the bombings in a colonial past.
Building a Public Culture of Pandemic Storytelling
Authors: Yang Guobin , Moses Adetobi
Published: April 2023

From the very beginning of the COVID-19 pandemic, ordinary people around the world have been documenting their experiences in diverse media forms, giving rise to a public culture of pandemic storytelling. This public culture, however, can be transitory. Personal stories may disappear for many reasons. The authors call for scholars to help build and sustain this public culture through the work of digital archiving and research, and the authors emphasize a descriptive imperative, as opposed to theorizing, as the more urgent course of action.
Parking Search in the Physical World: Calculating the Search Time by Leveraging Physical and Graph Theoretical Methods
Authors: Dutta Nilankur , Charlottin Thibault , Nicolas Alexandre
Published: April 2023

Parking plays a central role in transport policies and has wide-ranging consequences: While the average time spent searching for parking exceeds dozens of hours per driver every year in many Western cities, the associated cruising traffic generates major externalities, by emitting pollutants and contributing to congestion. However, the laws governing the parking search time remain opaque in many regards, which hinders any general understanding of the problem and its determinants. Here, we frame the problem of parking search in a very generic, but mathematically compact formulation that puts the focus on the role of the street network and the unequal attractiveness of parking spaces. This problem is solved in two independent ways, valid in any street network and for a wide range of drivers’ behaviours. Numerically, this is done by means of a computationally efficient and versatile agent-based model. Analytically, we leverage the machinery of Statistical Physics and Graph Theory to derive a generic mean-field relation giving the parking search time as a function of the occupancy of parking spaces; an expression for the latter is obtained in the stationary regime. We show that these theoretical results are applicable in toy networks as well as in complex, realistic cases such as the large-scale street network of the city of Lyon, France. Taken as a whole, these findings clarify the parameters that directly control the search time and provide transport engineers with a quantitative grasp of the parking problem. Besides, they establish formal connections between the parking issue in realistic settings and physical problems.

Funding: This work was supported by IDEXLYON (IDEXLYON 2020–2021); Institut Rhonalpin des Systèmes Complexes (IXXI) (Vulnerabilite).

Supplemental Material: The e-companion is available at https://doi.org/10.1287/trsc.2023.1206 .
Avoiding and managing the side effects of type 2 diabetes treatments
Authors: Morris David
Published: April 2023

This article examines approaches to reduce the risk of side effects caused by medications for type 2 diabetes and how to manage these side effects should they occur. Before starting medication, the benefits of improved glycaemic control and other treatment gains should be weighed against the risk of side effects. The decision to use a treatment to enhance glycaemic control should be made in consultation with the patient, taking into account their specific circumstances and vulnerability to adverse events resulting from the treatment. It is essential to provide a warning about potential medication side effects and how to manage them. Strategies to avoid or minimise the risk of side effects, as well as what actions to take should they occur, are discussed in this article. The side effects of commonly used drug classes in type 2 diabetes are reviewed.
Formation of a D-shaped optical fiber by in-cavity online polishing for high resolution sensing in a chaotic correlation fiber loop ring down system
Authors: Liu Jiaojiao , Yang Lingzhen , Wang Juanfen , Xue Pingping , Fan Linlin , Jiang Qi
Published: April 2023

Online monitoring of the polishing process of a D-shaped optical fiber sensor is performed in this paper by means of a chaotic correlation fiber loop ring down (CCFLRD) system. The ring down time of the autocorrelation coefficient decreases with the increase in polishing loss caused by different mesh sizes. A comparison of the sensitivity and resolution of the CCFLRD system with different polishing losses in the length of a fiber loop cavity are carried out. Online polishing in the fiber loop cavity with a very short length is proposed and demonstrated using different polishing mesh numbers to increase the sensitivity and resolution of the system. A high sensitivity of 31.871ns−1RIU−1 and resolution of 10−4RIU for refractive index sensing in the range of 1.3347–1.3721 correspond to different concentrations of sodium chloride.
Comparative study of lidars for measuring atmospheric temperature and wind
Authors: She Chiao-Yao , Krueger David A. , Yan Zhao-Ai
Published: April 2023

The uncertainty of lidar measured atmospheric temperature T or line-of-sight (LOS) wind V is inversely proportional to the
signal-to-noise ratio (SNR) of the received photocounts. We term the
proportionality constant, which depicts the efficacy of the
measurement method, the single-photon (or unity SNR) measurement
uncertainty for T and/or V measurement. In this study, we use
the single-photon measurement uncertainty as the figure of merit to
compare and understand the practical differences between Cabannes
scattering (CS), Rayleigh inversion (RI), rotational Raman (RR), and
laser induced fluorescence (LIF) lidars for atmospheric temperature
and wind measurements, and to optimize the choice and receiver design
of a lidar system for a potential application.
Origins of the short circuit current of a current mismatched multijunction photovoltaic cell considering subcell reverse breakdown
Authors: Wang An-Cheng , Yin Jia-Jing , Yu Shu-Zhen , Sun Yu-Run , Dong Jian-Rong
Published: April 2023

In the photovoltaic community, short circuit current (Isc) of a current mismatched multijunction photovoltaic (MJPV) cell was usually thought to be limited by the lowest subcell photocurrent (Imin). However, under certain conditions for multijunction solar cells, Isc≠Imin was observed by researchers, while this effect has not been studied in multijunction laser power converters (MJLPCs). In this work, we provide an in-depth analysis of the formation mechanisms for the Isc of the MJPV cell by measuring I-V curves of the GaAs and InGaAs LPCs with different number of subcells and simulating the I-V curves with the reverse breakdown of each subcell considered. It is found that Isc of an N-junction PV cell can be theoretically equal to any current value within a range from a current lower than Imin to the maximum subcell photocurrent, which is up to the number of subcell current steps in the forward biased I-V curve. An MJPV cell with a constant Imin will demonstrate a higher Isc if it has more subcells, smaller subcell reverse breakdown voltage and smaller series resistance. As a result, Isc tends to be limited by the photocurrent of a subcell closer to the middle cell and is less sensitive to the optical wavelength than Imin. This should be another possible reason why the measured EQE of a multijunction LPC exhibits a wider spectrum width than the calculated Imin-based EQE, whereas this was usually attributed to the luminescent coupling effect merely.
High-power deep-ultraviolet light generation at 266 nm from frequency quadrupling of a picosecond pulsed 1064 nm laser with a Nd:YVO4 amplifier pumped by a 914 nm laser diode
Authors: Orii Yosuke , Yoshii Kento , Kohno Kenta , Tanaka Hiroki , Shibuya Kimihiko , Okada George , Mori Yusuke , Nishimae Junichi , Yoshimura Masashi
Published: April 2023

We report the generation of picosecond pulsed light at a 266 nm wavelength with an average power of 53 W. We developed a picosecond pulsed 1064 nm laser source with an average power of 261 W, a repetition rate of 1 MHz, and a pulse duration of 14 ps, using a gain-switched DFB laser diode as a seed laser and a 914 nm laser-diode-pumped Nd-doped YVO4 power amplifier. We achieved stable generation of 266 nm light with an average power of 53 W from frequency quadrupling using an LBO and a CLBO crystals. The amplified power of 261 W and the 266 nm average power of 53 W from the 914 nm pumped Nd:YVO4 amplifier are the highest ever reported, to the best of our knowledge.
Sb2Se3/CdS/ZnO photodetectors based on physical vapor deposition for color imaging applications
Authors: Li Yaping , Huang Bo , Liu Yujin , Lan Linfeng , Ji Zhong
Published: April 2023

The reported antimony selenide (Sb2Se3) photodetectors (PDs) are still far away from color camera applications mainly due to the high operation temperature required in chemical vapor deposition (CVD) and the lack of high-density PD arrays. In this work, we propose a Sb2Se3/CdS/ZnO PD created by physical vapor deposition (PVD) operated at room temperature. Using PVD, a uniform film can be obtained, so the optimized PD has excellent photoelectric performance with high responsivity (250 mA/W), high detectivity (5.6 × 1012 Jones), low dark current (∼10−9 A), and short response time (rise: < 200 μs; decay: < 200 μs). With the help of advanced computational imaging technology, we successfully demonstrate color imaging applications by the single Sb2Se3 PD; thus, we expect this work can bring Sb2Se3 PDs in color camera sensors closer.
Metasurface-based perfect vortex beams with trigonometric-function topological charge for OAM manipulation
Authors: Zhang Bolun , Hu Zheng-Da , Wu Jingjing , Wang Jicheng , Nie Yanguang , Zhang Feng , Li Mengmeng , Khakhomov Sergei
Published: April 2023

Topological charge (TC) is generally acknowledged as an important attribute of an optical vortex (OV), which indicates the twisted characterization of the wavefront. In most circumstances, the TC remains constant as an integer or fraction along the azimuthal direction. Herein, by transforming the TCs into the trigonometric functions of the azimuthal angle to tailor the spiral phase distributions, we numerically demonstrate generating perfect vortex beams (PVBs) with sine-function TC based on the all-dielectric geometric metasurfaces, whose unit structure is optimized to an ideal half-wave plate. To seek the intrinsic advancements of the proposed PVBs, their orbital angular momentum (OAM) as well as optical gradient force distributions are calculated for diverse particle manipulation. We believe our proposed scheme is desired to provide an original thought for OAM manipulation, information storage, and optical communication.
Hollow core fiber Fabry-Perot interferometers with reduced sensitivity to temperature: erratum
Authors: Ding Meng , Numkam Fokoua Eric , Hayes John R. , Sakr Hesham , Horak Peter , Poletti Francesco , Richardson David J. , Slavík Radan
Published: April 2023

In the original publication of our research article “Hollow core fiber Fabry-Perot interferometers with reduced sensitivity to temperature” [Opt. Lett. 47, 2510 (2022)10.1364/OL.456589OPLEDP0146-9592], we identified an error that requires correction. The authors sincerely apologize for any confusion that may have arisen from this error. The correction does not affect the overall conclusions of the paper.
Inferring assembly-curving trends of bacterial micro-compartment shell hexamers from crystal structure arrangements
Authors: Garcia-Alles Luis F. , Fuentes-Cabrera Miguel , Truan Gilles , Reguera David
Published: April 2023

Bacterial microcompartments (BMC) are complex macromolecular assemblies that participate in varied chemical processes in about one fourth of bacterial species. BMC-encapsulated enzymatic activities are segregated from other cell contents by means of semipermeable shells, justifying why BMC are viewed as prototype nano-reactors for biotechnological applications. Herein, we undertook a comparative study of bending propensities of BMC hexamers (BMC-H), the most abundant shell constituents. Published data show that some BMC-H, like β-carboxysomal CcmK, tend to assemble flat whereas other BMC-H often build curved objects. Inspection of available crystal structures presenting BMC-H in tiled arrangements permitted us to identify two major assembly modes with a striking connection with experimental trends. All-atom molecular dynamics (MD) supported that BMC-H bending is triggered robustly only from the arrangement adopted in crystals by BMC-H that experimentally form curved objects, leading to very similar arrangements to those found in structures of recomposed BMC shells. Simulations on triplets of planar-behaving hexamers, which were previously reconfigured to comply with such organization, confirmed that bending propensity is mostly defined by the precise lateral positioning of hexamers, rather than by BMC-H identity. Finally, an interfacial lysine was pinpointed as the most decisive residue in controlling PduA spontaneous curvature. Globally, results presented herein should contribute to improve our understanding of the variable mechanisms of biogenesis characterized for BMC, and of possible strategies to regulate BMC size and shape.
Sexually transmitted infections amongst men who have sex with men (MSM) in South Africa
Authors: Mashingaidze Rujeko , Moodie Zoe , Allen Mary , Bekker Linda-Gail , Grove Doug , Grunenberg Nicole , Huang Yunda , Janes Holly E. , Lazarus Erica Maxine , Malahleha Mookho , Nchabeleng Maphoshane , Laher Fatima
Published: April 2023

There is limited data about bacterial STIs in MSM populations in sub-Saharan Africa. Our retrospective analysis used data from the HVTN 702 HIV vaccine clinical trial (October 2016 to July 2021). We evaluated multiple variables. Polymerase chain reaction testing was conducted on urine and rectal samples to detect Neisseria gonorrhoea (NG) and Chlamydia trachomatis (CT) every 6 months. Syphilis serology was conducted at month 0 and thereafter every 12 months. We calculated STI prevalence and the associated 95% confidence intervals until 24 months of follow-up. The trial enrolled 183 participants who identified as male or transgender female, and of homosexual or bisexual orientation. Of these, 173 had STI testing done at month 0, median age was 23 (IQR 20–25) years, with median 20.5 (IQR 17.5–24.8) months follow-up (FU). The clinical trial also enrolled and performed month 0 STI testing on 3389 female participants, median age 23 (IQR 21–27) years, median 24.8 (IQR 18.8–24.8) months FU and 1080 non-MSM males with a median age of 27 (IQR 24–31) years, median 24.8 (IQR 23–24.8) months FU. At month 0, CT prevalence was similar in MSM and females (26.0% vs 23.0%, p = 0.492) but was more prevalent in MSM compared to non-MSM males (26.0% vs 14.3%, p = 0.001). CT was the most prevalent STI among MSM at months 0 and 6 but declined from month 0 to month 6 (26.0% vs 17.1%, p = 0.023). In contrast, NG did not decline in MSM between months 0 and 6 (8.1% vs 7.1%, p = 0.680) nor did syphilis prevalence between months 0 and 12 (5.2% vs 3.8%, p = 0.588). Bacterial STI burden is higher in MSM compared to non-MSM males, and CT is the most prevalent bacterial STI amongst MSM. Preventive STI vaccines, especially against CT, may be helpful to develop.
Scorpion envenomation-associated myocarditis: A systematic review
Authors: Fereidooni Reza , Shirzadi Saeedreza , Ayatizadeh Seyyed Hamidreza , Bahloul Mabrouk , Tavangar Amirali , Zomorodian Seyed Alireza , Roshanshad Amirhossein , Ardekani Ali
Published: April 2023

Background

Scorpion envenomation is associated with several complications. One of the most serious complications is the cardiac involvement in the form of myocarditis that remains the main reason for mortalities associated with scorpion envenomation. The present review aims to elucidate clinical and paraclinical findings associated with scorpion-related myocarditis, and to explore different management strategies and subsequent outcomes.

Methods

We searched PubMed, Web of Science, Scopus, and Google Scholar for articles related to keywords of myocarditis associated with scorpion envenomation up to May 1, 2022. Each article was carefully reviewed by two independent researchers. In case of disagreement for inclusion, we sought a third researcher opinion.

Results

A total of 703 cases from 30 case reports and 34 case series were included in our review. Myocarditis associated with scorpion envenomation was usually reported in children presenting with cardiopulmonary symptoms including pulmonary edema (60.7%) and shock or hypotension (45.8%). The most common ECG findings are sinus tachycardia (82%) followed by ST-T changes (64.6%). The management typically included inotropes (especially dobutamine), prazosin, diuretics, nitroglycerine and digoxin, when indicated. Mechanical ventilation was required in 36.7% of the patients. Mortality in confirmed scorpion-related myocarditis cases is estimated at 7.3%. Almost all survived cases showed rapid recovery and improvement in the left ventricular function.

Conclusion

Even though myocarditis associated with scorpion envenomation is rare, it remains a serious and in some of cases a fatal consequence of scorpion sting. In case of relative presentations, particularly in envenomed children, diagnosis of myocarditis should be considered. Early screening using serial cardiac markers and echocardiography can guide the treatment. Prompt treatment that focuses on cardiogenic shock and pulmonary edema usually results in a favorable outcome.
A novel integrative multi-omics approach to unravel the genetic determinants of rare diseases with application in sinusoidal obstruction syndrome
Authors: Waespe Nicolas , Mlakar Simona Jurkovic , Dupanloup Isabelle , Rezgui Mohamed Aziz , Bittencourt Henrique , Krajinovic Maja , Kuehni Claudia E. , Nava Tiago , Ansari Marc
Published: April 2023

Background

Genotype-phenotype analyses of rare diseases often suffer from a lack of power, due to small sample size, which makes identifying significant associations difficult. Sinusoidal obstruction syndrome (SOS) of the liver is a rare but life-threatening complication of hematopoietic stem cell transplantation (HSCT). The alkylating agent busulfan is commonly used in HSCT and known to trigger SOS. We developed a novel pipeline to identify genetic determinants in rare diseases by combiningin vitroinformation with clinical whole-exome sequencing (WES) data and applied it in SOS patients and controls.

Methods

First, we analysed differential gene expression in six lymphoblastoid cell lines (LCLs) before and after incubation with busulfan. Second, we used WES data from 87 HSCT patients and estimated the association with SOS at the SNP and the gene levels. We then combined the results of the expression and the association analyses into an association statistic at the gene level. We used an over-representation analysis to functionally characterize the genes that were associated with a significant combined test statistic.

Results

After treatment of LCLs with busulfan, 1708 genes were significantly up-, and 1385 down-regulated. The combination of the expression experiment and the association analysis of WES data into a single test statistic revealed 35 genes associated with the outcome. These genes are involved in various biological functions and processes, such as “Cell growth and death”, “Signalling molecules and interaction”, “Cancer”, and “Infectious disease”.

Conclusions

This novel data analysis pipeline integrates two independent omics datasets and increases statistical power for identifying genotype-phenotype associations. The analysis of the transcriptomics profile of cell lines treated with busulfan and WES data from HSCT patients allowed us to identify potential genetic contributors to SOS. Our pipeline could be useful for identifying genetic contributors to other rare diseases where limited power renders genome-wide analyses unpromising.

Trial registration

For the clinical dataset: Clinicaltrials.gov:NCT01257854.https://clinicaltrials.gov/ct2/history/NCT01257854.
Trends in voice characteristics in patients with heart failure (VENTURE) in Switzerland: Protocol for a longitudinal observational pilot study
Authors: Wu Fan , Nägele Matthias , Cleres David , Haider Thomas , Fleisch Elgar , Ruschitzka Frank , Flammer Andreas , Barata Filipe
Published: April 2023

Introduction

Heart Failure (HF) is a major health and economic issue worldwide. HF-related expenses are largely driven by hospital admissions and re-admissions, many of which are potentially preventable. Current self-management programs, however, have failed to reduce hospital admissions. This may be explained by their low predictive power for decompensation and high adherence requirements. Slight alterations in the voice profile may allow to detect decompensation in HF patients at an earlier stage and reduce hospitalizations. This pilot study investigates the potential of voice as a digital biomarker to predict health status deterioration in HF patients.

Methods and analysis

In a two-month longitudinal observational study, we collect voice samples and HF-related quality-of-life questionnaires from 35 stable HF patients. Patients use our developed study application installed on a tablet at home during the study period. From the collected data, we use signal processing to extract voice characteristics from the audio samples and associate them with the answers to the questionnaire data. The primary outcome will be the correlation between voice characteristics and HF-related quality-of-life health status.

Ethics and dissemination

The study was reviewed and approved by the Cantonal Ethics Committee Zurich (BASEC ID:2022-00912). Results will be published in medical and technical peer-reviewed journals.
Healthcare resource utilisation and cost of pneumococcal disease from 2003 to 2019 in children ≤17 years in England
Authors: Mohanty Salini , Podmore Bélène , Cuñado Moral Ana , Matthews Ian , Sarpong Eric , Azpeitia Agueda , Qizilbash Nawab
Published: April 2023

Objective

To estimate healthcare resource utilisation (HCRU) and costs associated with pneumococcal disease (PD) in children aged ≤17 years in England from 2003–2019.

Methods

A retrospective study in children aged ≤17 years was conducted using the Clinical Practice Research Datalink Gold primary care database and Hospital Episodes Statistics Admitted Patient Care database from 2003–2019. Episodes of invasive pneumococcal disease (IPD) were identified in hospital, pneumococcal pneumonia (PP) and all-cause pneumonia (ACP) episodes in primary care and in hospital, and acute otitis media (AOM) episodes in primary care. General practitioner (GP) visits and inpatient admission yearly rates were calculated per 1,000 persons. The average inpatient and primary care cost per episode were calculated. The Mann-Kendall test was used to assess monotonic time trends.

Results

1,500,686 children were followed from 2003–2019. The highest average inpatient cost per episode [£34,255 (95%CI 27,222–41,288)] was in IPD, followed by ACP [£3,549 (95%CI 3,405–3,693)] and PP [£1,498 (95%CI 1,153–1,843)]. The highest primary care costs per episode were in AOM [£48.7 (95%CI 48.7–48.7)], followed by PP [£38.4 (95%CI 37.0–39.7)] and ACP [£28.6 (95%CI 28.2–29.1)]. The highest inpatient admission and GP visits yearly rates were observed in children aged <2 years. Across years, a significant decrease in GP visits yearly rates was observed for PP, ACP and AOM in children overall (p-value<0.001). A decrease in primary care costs was observed for ACP (p-value<0.001). There was an increasing trend in AOM primary care costs (p-value<0.001). No significant trends were observed in inpatient admission yearly rates in PP, ACP or IPD and inpatient costs per episode in PP, ACP and IPD.

Conclusion

From 2003–2019, primary care HCRU and costs decreased (except for PP cost), but no trends in inpatient HCRU and costs were observed. The economic burden of pneumonia, IPD and AOM remains substantial in children aged ≤17 years in England.
Identification of Crown of Thorns Starfish (COTS) using Convolutional Neural Network (CNN) and attention model
Authors: Heenaye- Mamode Khan Maleika , Makoonlall Anjana , Nazurally Nadeem , Mungloo- Dilmohamud Zahra
Published: April 2023

Coral reefs play important roles in the marine ecosystem, from providing shelter to aquatic lives to being a source of income to others. However, they are in danger from outbreaks of species like the Crown of Thorns Starfish (COTS) and the widespread coral bleaching from rising sea temperatures. The identification of COTS for detecting outbreaks is a challenging task and is often done through snorkelling and diving activities with limited range, where strong currents result in poor image capture, damage of capturing equipment, and are of high risks. This paper proposes a novel approach for the automatic detection of COTS based Convolutional Neural Network (CNN) with an enhanced attention module. Different pre-trained CNN models, namely, VGG19 and MobileNetV2 have been applied to our dataset with the aim of detecting and classifying COTS using transfer learning. The architecture of the pre-trained models was optimised using ADAM optimisers and an accuracy of 87.1% was achieved for VGG19 and 80.2% for the MobileNetV2. The attention model was developed and added to the CNN to determine which features in the starfish were influencing the classification. The enhanced model attained an accuracy of 92.6% while explaining the causal features in COTS. The mean average precision of the enhanced VGG-19 with the addition of the attention model was 95% showing an increase of 2% compared to only the enhanced VGG-19 model.
A repeatable scoring system for assessing Smartphone applications ability to identify herbaceous plants
Authors: Campbell Neil , Peacock Julie , Bacon Karen L.
Published: April 2023

The ubiquity of Smartphone applications that aim to identify organisms, including plants, make them potentially useful for increasing people’s engagement with the natural world. However, how well such applications actually identify plants has not been compressively investigated nor has an easily repeatable scoring system to compare across plant groups been developed. This study investigated the ability of six common Smartphone applications (Google Lens, iNaturalist, Leaf Snap, Plant Net, Plant Snap, Seek) to identify herbaceous plants and developed a repeatable scoring system to assess their success. Thirty-eight species of plant were photographed in their natural habitats using a standard Smartphone (Samsung Galaxy A50) and assessed in each app without image enhancement. All apps showed considerable variation across plant species and were better able to identify flowers than leaves. Plant Net and Leaf Snap outperformed the other apps. Even the higher preforming apps did not have an accuracy above ~88% and lower scoring apps were considerably below this. Smartphone apps present a clear opportunity to encourage people to engage more with plants. Their accuracy can be good, but should not be considered excellent or assumed to be correct, particularly if the species in question may be toxic or otherwise problematic.
Orthogeriatric co-management for older patients with a major osteoporotic fracture: Protocol of an observational pre-post study
Authors: Janssens Sigrid , Dejaeger Marian , Sermon An , Fagard Katleen , Cerulus Marie , Cosyns Heidi , Flamaing Johan , Deschodt Mieke
Published: April 2023

Background

Osteoporotic fractures are associated with postoperative complications, increased mortality, reduced quality of life, and excessive costs. The care for older patients with a fracture is often complex due to multimorbidity, polypharmacy, and presence of geriatric syndromes requiring a holistic multidisciplinary approach based on a comprehensive geriatric assessment. Nurse-led geriatric co-management has proven to prevent functional decline and complications, and improve quality of life. The aim of this study is to prove that nurse-led orthogeriatric co-management in patients with a major osteoporotic fracture is more effective than inpatient geriatric consultation to prevent in-hospital complications and several secondary outcomes in at least a cost-neutral manner.

Methods

An observational pre-post study will be performed on the traumatology ward of the University Hospitals Leuven in Belgium including 108 patients aged 75 years and older hospitalized with a major osteoporotic fracture in each cohort. A feasibility study was conducted after the usual care cohort and prior to the intervention cohort to measure fidelity to the intervention components. The intervention includes proactive geriatric care based on automated protocols for the prevention of common geriatric syndromes, a comprehensive geriatric evaluation followed by multidisciplinary interventions, and systematic follow-up. The primary outcome is the proportion of patients having one or more in-hospital complications. Secondary outcomes include functional status, instrumental activities of daily living status, mobility status, nutritional status, in-hospital cognitive decline, quality of life, return to pre-fracture living situation, unplanned hospital readmissions, incidence of new falls, and mortality. A process evaluation and cost-benefit analysis will also be conducted.

Discussion

This study wants to prove the beneficial impact of orthogeriatric co-management in improving patient outcomes and costs in a heterogenous population in daily clinical practice with the ambition of long-term sustainability of the intervention.

Trial registration

International Standard Randomised Controlled Trial Number (ISRCTN) Registry: ISRCTN20491828. Registered on October 11, 2021, https://www.isrctn.com/ISRCTN20491828.
Attention for and awareness of anemia in adolescents in Karnataka, India: A qualitative study
Authors: Gillespie Bronwen , Katageri Geetanjali , Salam Shumona , Ramadurg Umesh , Patil Shrinivas , Mhetri Jayaraj , Charantimath Umesh , Goudar Shivaprasad , Dandappanavar Ashwini , Karadiguddi Chandrashekhar , Mallapur Ashalata , Vastrad Phaniraj , Roy Subarna , Peerapur Basavaraj , Anumba Dilly
Published: April 2023

Between 1990 and 2016 the number of adolescents with anemia world-wide increased by 20% to almost one in four. Iron deficiency in adolescence results in compromised growth, decreased cognitive function, and depressed immune function, and can increase the risk of negative outcomes in pregnancy, especially in the case of young adolescents. In India, despite several decades of governmental investment in anemia prevention and treatment, more than half of women of reproductive age are anemic, with rates even higher in the adolescent population. Although awareness of adolescence as a nutrition-sensitive developmental stage is increasing, there is a lack of qualitative research on the perspectives of adolescents and families on anemia and related services. In this study, we explored the issues influencing adolescents’ awareness of anemia in three rural areas of Karnataka. Sixty-four in-depth interviews and six focus group discussions were conducted with adolescents (those who had never been pregnant, pregnant adolescents, and young mothers), community members, and nutrition-related service providers in the health and education sectors. An inductive analytical approach was used. We found that adolescent girls, particularly those who have not experienced pregnancy or motherhood, had very low awareness of anemia. State programs including school-based distribution of iron and folic acid supplements and nutrition talks were not seen to be resulting in knowledge and acceptance of the importance of preventing anemia. Pregnancy represents a turning point in which adolescents are systematically tested for anemia as part of routine antenatal care, increasing their awareness of, and access to, treatment for the condition. At the same time, pregnancy represents to family and community a period to insist on a nutritious diet. For progress in anemia reduction to be made, improved age-appropriate measures specific for adolescence are required. Improving school-based nutrition outreach is an important opportunity to reach adolescents.
Emotional tones of voice affect the acoustics and perception of Mandarin tones
Authors: Chang Hui-Shan , Lee Chao-Yang , Wang Xianhui , Young Shuenn-Tsong , Li Cheng-Hsuan , Chu Woei-Chyn
Published: April 2023

Lexical tones and emotions are conveyed by a similar set of acoustic parameters; therefore, listeners of tonal languages face the challenge of processing lexical tones and emotions in the acoustic signal concurrently. This study examined how emotions affect the acoustics and perception of Mandarin tones. In Experiment 1, Mandarin tones were produced by professional actors with angry, fear, happy, sad, and neutral tones of voice. Acoustic analyses on mean F0, F0 range, mean amplitude, and duration were conducted on syllables excised from a carrier phrase. The results showed that emotions affect Mandarin tone acoustics to different degrees depending on specific Mandarin tones and specific emotions. In Experiment 2, selected syllables from Experiment 1 were presented in isolation or in context. Listeners were asked to identify the Mandarin tones and emotions of the syllables. The results showed that emotions affect Mandarin tone identification to a greater extent than Mandarin tones affect emotion recognition. Both Mandarin tones and emotions were identified more accurately in syllables presented with the carrier phrase, but the carrier phrase affected Mandarin tone identification and emotion recognition to different degrees. These findings suggest that lexical tones and emotions interact in complex but systematic ways.
The dynamics of a duopoly Stackelberg game with marginal costs among heterogeneous players
Authors: Ahmadi Atefeh , Roy Sourav , Mehrabbeik Mahtab , Ghosh Dibakar , Jafari Sajad , Perc Matjaž
Published: April 2023

One of the famous economic models in game theory is the duopoly Stackelberg model, in which a leader and a follower firm manufacture a single product in the market. Their goal is to obtain the maximum profit while competing with each other. The desired dynamics for a firm in a market is the convergence to its Nash equilibrium, but the dynamics of real-world markets are not always steady and can result in unpredictable market changes that exhibit chaotic behaviors. On the other hand, to approach reality more, the two firms in the market can be considered heterogeneous. The leader firm is bounded rationale, and the follower firm is adaptable. Modifying the cost function that affects the firms’ profit by adding the marginal cost term is another step toward reality. We propose a Stackelberg model with heterogeneous players and marginal costs, which exhibits chaotic behavior. This model’s equilibrium points, including the Nash equilibrium, are calculated by the backward induction method, and their stability analyses are obtained. The influence of changing each model parameter on the consequent dynamics is investigated through one-dimensional and two-dimensional bifurcation diagrams, Lyapunov exponents spectra, and Kaplan-Yorke dimension. Eventually, using a combination of state feedback and parameter adjustment methods, the chaotic solutions of the model are successfully tamed, and the model converges to its Nash equilibrium.
Investigating donor human milk composition globally to develop effective strategies for the nutritional care of preterm infants: Study protocol
Authors: Perrin Maryanne T. , Mansen Kimberly , Israel-Ballard Kiersten , Richter Scott , Bode Lars , Hampel Daniela , Shahab-Ferdows Setareh , Allen Lindsay H. , Maggio Francisca Cofré , Njuguna Emily , Tran Hoang Thi , Wesolowska Aleksandra
Published: April 2023

Background

Globally, almost 15 million infants are born prematurely each year, disproportionately affecting low and middle-income countries. In the absence of mother’s milk, the World Health Organization recommends using donor human milk (DHM) due to its protective effect against necrotizing enterocolitis, a life-threatening intestinal disorder. The use of DHM is increasing globally, with many low and middle-income countries integrating donor milk banks into their public health strategies to reduce neonatal mortality, yet very little is known about the nutritional composition of DHM. Additional knowledge gaps include how DHM composition is influenced by milk banking practices, and whether preterm nutrient recommendations are achieved when DHM is used with commercially available fortifiers.

Methods

We designed a multi-site study with eight geographically diverse milk bank partners in high, middle, and low-income settings that will examine and compare a broad range of nutrients and bioactive factors in human milk from 600 approved milk bank donors around the world to create comprehensive, geographically diverse nutrient profiles for DHM. We will then simulate the random pooling of 2 to 10 donors to evaluate the impact of pooling as a potential strategy for milk banks to manage nutrient variability in DHM. Finally, we will evaluate whether commercially available fortifiers meet nutrient recommendations when used with DHM.

Discussion

We expect that results from this study will improve nutritional care globally for the growing number of preterm infants who receive donor human milk.
A model for estimating costs and benefits of new vaccine technologies from the perspective of both buyers and sellers
Authors: Krautmann Michael , Davis Ben , Leroueil Pascale R.
Published: April 2023

Although vaccination is widely considered one of the most cost-effective health interventions available, global coverage rates for many vaccines remain lower than necessary for disease elimination and eradication. New vaccine technologies can play an important role in addressing barriers to vaccination and increasing coverage rates. To identify and prioritize vaccine technology investments, decision makers must be able to compare the overall costs and benefits of each investment option. While these data points may exist, they are often confined to silos. Decision makers would benefit from a model that synthesizes this broad range of data and provides clear and actionable information. To facilitate vaccine investment, purchasing and deployment decisions, we developed a systematic and transparent cost-benefit model that estimates the value and risk of a given investment scenario from the perspective of both “buyers” (e.g., global donors, country governments) and “sellers” (e.g., developers, manufacturers) of vaccines. This model, which can be used to evaluate scenarios related to a single vaccine presentation or a portfolio of vaccine presentations, leverages our published approach for estimating the impact of improved vaccine technologies on vaccination coverage rates. This article presents a description of the model and provides an illustrative example application to a portfolio of measles-rubella vaccine technologies currently under development. Although the model is generally applicable to organizations involved in vaccine investment, manufacturing or purchasing, we believe it may be particularly useful to those engaged in vaccine markets that rely strongly on funding from institutional donors.
Sexual dysfunction among six months postpartum women in north-eastern Malaysia
Authors: Ng Ying Ying , Muhamad Rosediani , Ahmad Imran
Published: April 2023

Female sexual dysfunction (FSD) is a common problem among postpartum women. However, little is known about this topic in Malaysia. This study aimed to determine the prevalence of sexual dysfunction and its associated factors in postpartum women in Kelantan, Malaysia. In this cross-sectional study, we recruited 452 sexually active women at six months postpartum from four primary care clinics in Kota Bharu, Kelantan, Malaysia. The participants were asked to fill in questionnaires consisting of sociodemographic information and the Malay Version of the Female Sexual Function Index-6. The data were analyzed using bivariate and multivariate logistic regression analyses. With a 95% response rate, the prevalence of sexual dysfunction among sexually active, six months postpartum women was 52.4% (n = 225). FSD was significantly associated with the older husband’s age (p = 0.034) and lower frequency of sexual intercourse (p<0.001). Therefore, the prevalence of postpartum sexual dysfunction in women is relatively high in Kota Bharu, Kelantan, Malaysia. Efforts should be made to raise awareness among healthcare providers about screening for FSD in postpartum women and for their counseling and early treatment.
Disparity in neonatal abstinence syndrome by race/ethnicity, socioeconomic status, and geography, in neonates ≥ 35 weeks gestational age
Authors: Dookeran Keith A. , Feffer Marina G. , Quigley Kyla M. , Troller Phoebe E. , Christmon Chariya A. , Khan Janine Y.
Published: April 2023

Neonatal abstinence syndrome (NAS) is associated with a range of adverse health outcomes, exorbitant health care costs, and race/ethnicity disparity. We examined key sociodemographic factors that may influence the national race/ethnicity disparity in the prevalence of NAS among Whites, Blacks and Hispanics. 2016 and 2019 cycles of cross-sectional data from HCUP-KID national all-payer pediatric inpatient-care database were used to estimate NAS prevalence (ICD-10CM code P96.1) in newborns ≥ 35 weeks gestational-age, excluding iatrogenic-cases (ICD-10CM code P96.2). Multivariable generalized-linear-models with predictive-margins were used to produce race/ethnicity-specific stratified-estimates for select sociodemographic factors, reported as risk-differences (RD) with 95% confidence-intervals (CI). Final models were adjusted for sex, payer-type, ecologic income-level, and hospital size, type, and region. The overall survey weighted-sample prevalence of NAS was 0.98% (i.e., 6282/638100) and did not differ over cycles. Blacks and Hispanics were significantly more likely than Whites to be in the lowest ecologic income quartile and on Medicaid. In fully-specified models, NAS prevalence among Whites was 1.45% (95% CI: 1.33, 1.57) higher than Blacks and 1.52% (95% CI: 1.39, 1.64) higher than Hispanics; and NAS among Blacks was 0.14% higher than Hispanics (95% CI: 0.03, 0.24). NAS prevalence was highest among Whites on Medicaid (RD: 3.79%; 95% CI: 3.55, 4.03) compared to Whites on private-insurance (RD: 0.33%; 95% CI: 0.27, 0.38), and Blacks (RD: 0.73%; 95% CI: 0.63, 0.83; RD: 0.15%; 95% CI: 0.08, 0.21), or Hispanics, with either payer-type (RD: 0.59%; 95% CI: 0.5, 0.67; RD: 0.09%; 95% CI: 0.03, 0.15) respectively. NAS prevalence was higher among Whites in the lowest income-quartile (RD: 2.22%; 95% CI: 1.99, 2.44) compared with Blacks (RD: 0.51%; 95% CI: 0.41, 0.61) and Hispanics (RD: 0.44%; 95% CI: 0.33, 0.54) in the same quartile, and all subgroups in other quartiles. NAS prevalence was higher among Whites in the Northeast (RD: 2.19%; 95% CI: 1.89, 2.5) compared to Blacks (RD: 0.54%; 95% CI: 0.33, 0.74) and Hispanics (RD: 0.31%; 95% CI: 0.17, 0.45). Although Blacks and Hispanics were more likely to be in the lowest income quartile and have Medicaid insurance, Whites on Medicaid, in the lowest income quartile, and in the Northeast, were found to have the highest NAS prevalence.