bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Kualitas Pelayanan di Utopia Coffee Bistro Kota Martapura
Authors: Lindawati Lindawati , Yulianti Mira , Wilda Kamiliah
Published: December 2024

Penelitian ini bertujuan mengukur dan menganalisis kualitas pelayanan telah diberikan oleh Utopia Coffee Bistro kepada pelanggan, mengukur dan menganalisis pelayanan yang telah diberikan oleh Utopia Coffee Bistro kepada pelanggan telah sesuai antara tingkat kepentingan kualitas pelayanan dengan kinerja kualitas pelayanan. Data primer di peroleh dari kuesioner yang disebarkan kepada responden dan data yang telah diolah peneliti. Metode pengumpulan data menggunakan kuesioner dan teknik accidental sampling. Pengunjung yang datang akan diminta untuk mengisi kuisioner melalui Google Form atau secara langsung. Pengunjung yang dijadikan sampel merupakan pelanggan yang berusia lebih dari 17 tahun, pernah berkunjung dan mengonsumsi makanan dan minuman di Utopia Coffee Bistro lebih dari 1 kali. Analisis yang digunakan metode importance performance analysis (IPA). Pada penelitian ini survei yang dilakukan kepada 60 responden. Hasil penelitian menujukan terdapat beberapa karateristik ditempat penelitian seperti umur yang mayoritas berada pada rentang umur 21-30 tahun. Karakteristik menurut jenis kelamin didominasi perempuan dibanding laki-laki, karakeristik menurut jenis pekerjaan mayoritas responden adalah pegawai Swasta dan karakeristik estimasi jumlah pendapatan mayoritas adalah Rp. 3.000.000 – Rp. 3.900.000. Tingkat kepentingan tertinggi terdapat pada atribut kebersihan tempat dengan skor rata-rata mencapai 4,6 dan berada dalam kategori sangat penting. Atribut terendah ada pada atribut ketersediaan P3K untuk keselamatan dan pertolongan pertama dengan skor rata-rata 3,9. Tingkat kinerja tertinggi pada atribut pembayaran tunai dan nontunai dengan skor rata-rata 4,4 dan berada dalam kategori sangat puas (SP). Atribut terendah ada pada atribut ketersediaan P3K untuk keselamatan dan pertolongan pertama dengan skor rata-rata 3. Hal ini menunjukkan bahwa kualitas layanan yang diterima oleh pelanggan Utopia Coffee dan Bisto dinilai oleh pelanggan termasuk ke dalam kategori Memuaskan. Pada Importance Performance Analysis Kuadran kepentingan dan kinerja Dari gambar diatas dapat diketahui skor total rata-rata dan 𝑌 = 4,2 𝑋 = 4,12.
Analisis Pendapatan Usahatani Padi Sawah di Kecamatan Martapura Timur Kabupaten Banjar
Authors: Sibawaihi Ahmad , Yanti Nuri Dewi , Ikhsan Sadik
Published: December 2024

Tujuan dari penelitian ini mendeskripsikan penyelenggaraan usahatani padi, untuk menganalisis biaya produksi dan penerimaan petani dari usahatani padi, dan untuk menganalisis pendapatan petani dari usahatani padi sawah di Kecamatan Martapura Timur Kabupaten Banjar. Data yang digunakan dalam penelitian ini terdiri dari data primer dan sekunder. Data primer merupakan informasi yang dikumpulkan langsung dari lapangan dengan menggunakan kuesioner melalui wawancara dengan petani yang melakukan usahatani padi. Sedangkan data sekunder adalah informasi yang digunakan untuk mendukung analisis yang lebih mendalam dari topik yang dibahas. Penelitian ini dilakukan dengan menerapkan metode survei. Desa yang dipilih sebagai lokasi penelitian adalah Desa Akar Baru dan Desa Akar Begantung dengan alasan kedua desa ini yang paling banyak jumlah petani di Kecamatan Martapura Timur. Populasi kedua desa ini adalah 335 orang petani. Adapun jumlah petani contoh sebanyak 40 orang petani yang diambil secara acak sederhana (simple random sampling). Untuk mendeskripsikan penyelenggaraan usahatani padi, dilakukan dengan menggunakan analisis deskriptif. Untuk menganalisis pendapatan usahatani dilakukan perhitungan yaitu selisih peneriman dengan biaya produksi. Hasil penelitian diketahui bahwa rata-rata biaya eksplisit usahatani sebesar Rp 2.411.986/UT. Rata-rata produksi padi 1.093,22 kg/UT. Dengan harga jual Rp 9.038/kg, maka rata- rata penerimaan usahatani sebesar Rp 9.879.946/UT. Adapun pendapatan usahatani adalah hasil pengurangan penerimaan dengan biaya eksplisit yaitu Rp 9.879.946 - Rp 2.411.986 = Rp 7.467.960/UT.
Analisis Faktor-faktor yang Mempengaruhi Produksi Tomat di Kecamatan Astambul Kabupaten Banjar Provinsi Kalimantan Selatan
Authors: Rasyid Abdul , Muzdalifah Muzdalifah , Kurniawan Ahmad Yousuf
Published: December 2024

Banyak kendala yang dihadapi petani dalam usahatani tomat di Kecamatan Astambul, salah satu kendalanya petani yang belum memahami bagaimana faktor produksi tersebut digunakan secara efisien. Penelitian ini bertujuan mengidentifikasi aspek teknis budidaya penanaman tomat dan menganalisis faktor-faktor yang mempengaruhi produksi tomat di Kecamatan Astambul. Pengambilan sampel dilakukan dengan teknik purposive sampling terhadap Desa Tambak Danau, Pingaran Ulu dan Sungai Tuan Ulu. Jumlah responden yang diambil dengan metode sensus yaitu jumlah populasi petani tomat di tiga desa wilayah sampel sebanyak 67 orang petani. Metode analisis yang digunakan adalah dan analisis deskriptif dan analisis regresi linier berganda metode OLS. Berdasarkan hasil penelitian, Aspek teknik budidaya tomat di Kecamatan Astambul relatif masih menggunakan tenaga kerja secara konvensional atau manual. Faktor-faktor yang mempengaruhi secara signifikan terhadap produksi tomat, yaitu luas lahan, bibit, pupuk dan tenaga kerja.
DEPENDENCE OF THE VOLTAGE ON THE POWER ELECTRIC DIODES OF THE COMPENSATION CONVERTER ON THE FREQUENCY OF THE TRANSISTOR REVERSALS OF THE COMMUTATING LINK
Authors: Boyko Valery , Shkardun Oleksandr , Lyndyuk Bohdan
Published: December 2024

Studies of compensation-type electrical energy converters, conducted both by the authors of the publication and by other scientists, show that their energy characteristics and operating conditions of power equipment depend on commutating voltages. The tested three-phase bridge compensation converter contains one commutating link consisting of a three-phase capacitor battery and a three-phase group of fully controlled devices. The latter are a capacitor bank switch, performing the functions of switching capacitors in such a way as to ensure the energy process of the converter, in which its reactive energy is compensated, or generated, if necessary. At the same time, the operating conditions of the power equipment of the converter also change. The main content of the study is the analysis of the components of the reverse voltage of the power electric diodes of the compensation part of the converter and the dynamics of its change at an increased frequency of control pulses of the transistors of the commutating link. This is required when determining the class of diodes in the case of introducing a converter according to the scheme under study into production. The question of the class of diodves is considered in the context of the energy capabilities of the converter when regulating the operating mode according to the requirements of the technological process. The results of the research relate to the control of transistors of the commutating link by pulses of double, quadruple and eightfold frequency. As a result, relationships were obtained for calculating the maximum instantaneous value of the reverse voltage of electric power diodes in various operating modes of the converter. The ranges of the delay in the moment of supply of control pulses to the transistors of the commutating link are revealed. The generalized conclusion shows that on the electric power diodes of the compensation part of the converter, the reverse voltage does not exceed the voltage on other valves. Refer. 11, fig. 12.
RESEARCH OF IMPULSE OVERVOLTAGES IN HIGH VOLTAGE CABLE LINES WITH CROSS BONDING CABLE SHEATH
Authors: Lobodzinsky Vadim , Buryk Mykola
Published: December 2024

In the paper, a mathematical model of a power transmission cable line with cross bonding of screens is developed for the study and analysis of wave processes of overvoltage pulses during the cross bonding of screen contours. Equivalent and calculation schemes for the cross bonding of cable line shields are proposed, for which analytical expressions for calculating overvoltage maxima are obtained. Based on the analysis of the wave processes occurring in cross bonding cable shields of the three-phase system, it was established that when estimating the maximum voltage on the shields of the cable line, it is permissible not to take into account the waves reflected from the nodes located behind the node under consideration in the direction of wave travel. On the contrary, it is recommended to take into account the mutual influence of the phases, if we approximately accept the wave resistance of the screen-earth channel, which is equal to the wave resistance of the inter-screen channel. It has been established that taking into account the mutual influence of the phases leads to a decrease in the amplitude of the pulse and a reduction in the time of its influence, therefore, in order to calculate the overvoltage maxima, it is necessary to take into account the mutual influence between the screen-screen channels of neighboring phases.
MODERNIZATION OF SCHEDULED MAINTENANCE STRATEGIES FOR ACTIVE SAFETY SYSTEMS OF NUCLEAR POWER PLANTS WITH VVER
Authors: Skalozubov Vladimir , Verinov Olexii , Kanivets Andrii , Verbylo Ivan , Filatov Volodymyr
Published: December 2024

The strategies for scheduled tests and repairs of active safety systems (with pumps) established by the technological regulations for safe operation of VVER NPP do not take into account many years of operating experience and the results of numerous tests of active safety systems, current reliability indicators and residual life of the main equipment, and other factors. The modernization/improvement of design strategies for scheduled maintenance and testing of active safety systems determines the need to develop appropriate methods for qualifying (justifying) modernized strategies. The paper presents a risk-based method for qualifying modernization of strategies for scheduled maintenance of active safety systems, which takes into account the experience of operation, scheduled maintenance and testing, as well as the current reliability of the main equipment. The developed method is based on the following provisions. The determining reliability indicator for qualifying strategies for scheduled maintenance of active safety systems is the safety function unavailability factor, which determines the probability of a critical failure at the current time depending on the parameter of the intensity of the critical failure flow established in scheduled tests/repairs over the past service life. A critical failure here means a failure to perform safety functions (e.g., failure to turn on a pump, forced pump shutdown due to a violation of performance conditions, leaks in the circuits of active safety systems, etc.) The qualification criterion for the modernization of active safety systems outage strategies is a target risk function that determines the ratio of the coefficients of unreadiness to perform safety functions of the design and modernized active safety systems outage strategies. The conditions for successful qualification are that the unavailability rate of the safety functions of the modernized scheduled maintenance strategy is not greater than the unavailability rate of the design scheduled maintenance strategy. Based on the developed method, the modernized strategy of scheduled repairs of the active part of the emergency core cooling systems of the VVER-1000 reactor is substantiated, and the limitations of the applicability of the modernized strategy are determined.
POWER SUPPLY OF THE COMPLEX OF ENGINEERING AND TECHNICAL MEANS OF THE PHYSICAL PROTECTION SYSTEM IN CONDITIONS OF LONG-TERM POWER OUTAGES
Authors: Bibik Tymofii , Ostapenko Ivan , Feshchenko Dmytro
Published: December 2024

Physical security systems in today's conditions play a key role in maintaining nuclear security and ensuring the normal functioning of facilities in the nuclear power industry. Given the possible lack of electrical power caused by missile strikes in wartime, the enemy or criminals can take advantage of the vulnerability of the physical protection system, the means of which will be de-energized, which can lead to unacceptable radiation consequences [1] as a result of successfully executed illegal actions (sabotage, theft, etc.) ).
Therefore, in accordance with the legislation, a number of requirements are put forward to the power supplies of the complex of engineering and technical means of the physical security system, the fulfillment of which in the process of designing, construction or operation of the physical security system is aimed at preventing the failure of power supplies or minimizing the probability of failures in the reliable power supply of the equipment of the physical security n system protection
An important stage of ensuring the uninterrupted functioning of the physical security system in conditions of long-term emergency power outages is the selection of a generator set.
In this work, the object of research is the security of critical infrastructure objects in conditions of long-term power outages, and the subject of research is the power supply system of the complex of engineering and technical means of the physical security system. The paper analyzes the existing regulatory and legal documentation regarding physical security and provides the method of selecting a generator set, as well as the option of integrating the set into the scheme of power supplies of the complex of engineering and technical means. The main method of the process of selecting the specified equipment is the comparison and analysis of the parameters specified by the manufacturer with the parameters and characteristics that will meet the requirements of the current regulatory and legal documentation and the needs of the training center in supplying electricity to this or that equipment. The method presented in the paper is universal in application and can be scaled to other critical infrastructure facilities, where it is necessary to provide power supplies with a power reserve in conditions of long-term emergency shutdowns of industrial power sources.
ANALYSIS OF MICROGRID MANAGEMENT MODELS IN THE NATIONAL LEGISLATIVE AND REGULATORY SPACE
Authors: Kotsar Oleg , Kasianenko Yehor
Published: December 2024

The article examines the concept of "microgrid", microgrid models and microgrid classification. According to the results of the elaboration of the regulatory legal acts of EU and Ukraine, definitions and classification features of microgrid are proposed, which allow to identify individual models of microgrids. According to the results of the analysis, gaps in the legislation that restrain the development of microgrids have been identified.. References 25. Figures 6.
Uma análise dos pressupostos e das consequências do conceito de religião no programa “Escola Sem Partido”
Authors: Mendes Danilo
Published: December 2024

O presente artigo tem por objetivo analisar o projeto de lei n° 867, de 2015, apresentado à Câmara dos Deputados do Brasil pelo então deputado federal Izalci Lucas, denominado “Programa Escola Sem Partido” refletindo sobre como o projeto de lei mobiliza o conceito de religião, verificando seus pressupostos e suas consequências para o debate público. Para tal, apresentamos parte da história do movimento Escola Sem Partido, considerando sua gênese em uma querela religiosa, bem como leituras críticas ao movimento em sua antipedagogia. Passamos, então, a uma leitura do projeto de lei identificando todas as suas utilizações do termo “religião”, bem como de seu correlato “crença”, e refletindo acerca dos usos. Por fim, identificamos uma proximidade entre a noção de religião do projeto de lei e as táticas fundamentalistas de oposição e defesa.
As finalidades da homilia: uma abordagem à luz da patrística
Authors: Benedito André Luiz , Nobre José Aguiar
Published: December 2024

A reforma litúrgica promovida pelo Concílio Vaticano II empreendeu um universo de transformações rituais na Igreja ressoando na prática pastoral e na reflexão teológica. Dentre seus elementos, encontra-se a homilia. A reforma também acolheu importantes contribuições da teologia patrística. Porém, observa-se pouco aprofundamento nas relações entre a patrística e a pregação litúrgica. Metodologicamente é uma pesquisa de revisão bibliográfica, cujo objetivo consiste em abordar as finalidades da homilia à luz da patrística. Destacaremos suas três finalidades: explicativa, parenética e mistagógica. Em seguida, apresentaremos a iniciativa de Pierre Molinié que dialoga com os Padres Gregos no tocante ao tríplice munus da homilia: anunciar, celebrar e governar. Os resultados esperados consistem em evidenciar como as três dimensões se apresentam em algumas pregações de Ambrósio de Milão, cuja novidade aí reside. As ressonâncias entre a reforma litúrgica e a homilética ambrosiana evidenciam o avanço das contribuições patrísticas na prática litúrgica hodierna.
Ensino Religioso uma proposta para o Ensino Médio
Authors: Junqueira Sérgio , Itoz Sonia de
Published: December 2024

Para cumprir as finalidades do Ensino Médio, é proposto às instituições de ensino de caráter confessional, no processo de aprofundar e estabelecer a própria identidade, a darem prosseguimento ao componente curricular Ensino Religioso, contribuindo com a educação integral dos estudantes. A partir da área de Ciências Humanas e Sociais Aplicadas constitui-se um campo cognitivo dedicado aos estudos da existência humana e das intervenções sobre a vida, problematizando as relações sociais, os conhecimentos produzidos, a contribuição às culturas e suas normas, desenvolvendo o estudo de questões vinculadas ao fenômeno religioso que impactam diretamente no cotidiano das sociedades. Para o estudante de Ensino Médio, o conhecimento religioso deve favorecer a construção de relações saudáveis, de respeito e dignidade pelo outro.
Crise climática e escatologia do cuidado
Authors: Gonçalves Alonso S.
Published: December 2024

O artigo é sobre a escatologia da igreja e como esse ramo da teologia cristã pode contribuir para que a igreja trate as mudanças climáticas com compromisso ético e responsabilidade teológica. Para esse intento, estamos trabalhando a escatologia e sua relação com a crise climática, procurando demonstrar a contribuição que a mensagem de esperança da igreja pode ter nesse cenário de mudanças climáticas, começando pela própria igreja. Dessa maneira, este texto parte do pressuposto de que as mudanças climáticas são uma realidade e, por essa razão, não está em discussão a negação dessa realidade em hipótese alguma. Para que a igreja forneça uma escatologia do cuidado, tendo como discussão as mudanças climáticas, será preciso repensar aspectos da escatologia que, por algumas razões, prejudicaram a participação da igreja nesse debate. A proposta desse artigo é repensar a escatologia tendo no seu horizonte a crise climática que todos nós estamos envolvidos.
Religião, política e Jerusalém: por uma compreensão do sionismo cristão
Authors: Campos Breno Martins , Garutti da Silva Isabelle
Published: December 2024

No cenário mundial atual, observa-se que sistemas políticos, dinâmicas de poder e interesses religiosos frequentemente se transformam em questões de Estado. Este artigo, portanto, tem como objetivo principal compreender os efeitos da conexão entre o religioso e a política na sociedade internacional e nas dinâmicas globais, com especial atenção à situação no Oriente Médio (Israel e Palestina). De maneira interdisciplinar, esta pesquisa pretende analisar, sob perspectiva histórica, cultural e política, a criação do Estado moderno de Israel e do sionismo cristão, bem como investigar como a categoria histórico-teológica de Israel é interpretada pelo movimento sionista cristão, globalmente e no Brasil. Para tanto, a pesquisa assume metodologia bibliográfica e exploratória, utilizando uma abordagem qualitativa dos dados. Os resultados foram obtidos através da leitura e análise de livros, artigos e documentos, com o intuito de contribuir para os estudos acadêmicos e fomentar uma reflexão crítica sobre o tema.
Deformation and strengthening behavior of Al-Cu-based alloys at ambient and elevated temperatures
Authors: Shahhosseininia Mehran , Zamani Mohammadreza
Published: December 2024

Aluminum alloys typically exhibit low to intermediate strength. Heat treatment may improve their strength through precipitation hardening. Al-Cu-based alloys have shown appropriate mechanical properties based on their specific strengthening mechanisms. In this study, the as-cast Al-Cu (Mg-Ag-Ti-B) alloys were prepared at a medium cooling rate of 0.3 mm s−1. All specimens then underwent their specific solution heat treatment and artificial aging cycles. To evaluate the mechanical properties and deformation behavior of each alloy, the tensile test process was conducted at ambient and elevated (250°C) temperatures. For the Al-Cu-Mg-Ag class, the influence of grain size on yield strength (YS) and ultimate tensile strength (UTS) was studied. Fractography, the deformation behavior of each alloy was investigated at fracture surfaces using scanning electron microscopy (SEM). Results revealed that according to the precipitation hardening mechanism, the YS and UTS values were promoted after the heat-treatment procedure, while elongation-to-failure values were reduced compared with as-cast alloys. For elevated testing temperatures, the YS and UTS decreased or remained stable. The value of elongation to failure significantly increased compared to ambient temperature. The fine-grain size of the Al-Cu-Mg-Ag alloy indicated higher values of YS and UTS with a ductile behavior. SEM images illustrated that as-cast and heat-treated Al-Cu-Mg and Al-Cu-Mg-Ag alloys underwent a brittle deformation with intergranular-transgranular fracture mechanisms at ambient temperature. In contrast, at elevated testing temperatures, some dimples were observed to form. For as-cast and heat-treated Al-Cu and A205 alloys at ambient and elevated temperatures, small dimples with high depth were observed, confirming ductile deformation.
Twenty-Three Year Mortality in Parkinson’s Disease: A Population-Based Prospective Study (NEDICES)
Authors: Benito-Rodríguez Carla , Bermejo-Pareja Felix , Berbel Angel , Lapeña-Montilva José , Benito-León Julián
Published: December 2024

Parkinson's disease (PD) is a prevalent neurodegenerative disorder in older adults, yet its long-term mortality impact remains inadequately defined. This study builds on prior findings from the Neurological Disorders in Central Spain (NEDICES) cohort, extending mortality analysis to a 23-year follow-up within a Spanish population-based sample. This prospective cohort study included 5,278 individuals aged 65 years and older. Conducted in two waves (baseline and follow-up), it identified 81 prevalent PD cases at baseline (1994-95) and 30 incident (premotor) cases at follow-up (1994-95). Mortality was tracked for up to 23 years, with Cox proportional hazard models used to estimate mortality hazard ratios (HRs), adjusted for demographic and clinical variables. Among 111 PD cases, 109 (98.2%) died during follow-up, compared to 4,440 (86.8%) of 5,114 without PD. PD was associated with a significantly increased mortality risk (adjusted HR=1.62; 95% confidence interval [CI]=1.31–2.01). Individuals with both PD and dementia had an even higher risk (HR=2.19; 95% CI=1.24–3.89). Younger-onset PD (<65 years) showed heightened mortality risk (HR=2.11; 95% CI=1.22–3.64). Cardiovascular or cerebrovascular diseases were the leading causes of death in both PD and non-PD participants. PD was significantly more often listed as the primary cause of death in PD individuals compared to the reference group (14.7% vs. 0.4%, p<0.001). PD significantly increases mortality risk over 23 years, particularly among those with early onset and dementia. These findings support a multidisciplinary PD care approach that addresses both motor and non-motor symptoms to improve long-term outcomes.
Revealing The Crucial Role of Resilience on Mental Healthin Bullying Victims among Students: A Scoping Review
Authors: Mariyati Mariyati , Glorino Rumambo Pandin Moses , Yusuf Ah
Published: December 2024

Bullying in schools is a widespread global issue with significant negative consequences for its victims. Bullying victims frequently suffer from severe mental illness, such as sadness, anxiety, tension, and suicidal thinking. Resilience, the ability to adapt to and recover from difficulties, plays a crucial role in how bullying victims cope with their experiences. Research from numerous nations shows that resilience has a substantial influence on bullying victims' mental health and well-being. Resilience also promotes long-term healing from bullying. This study aimed to investigate the function of resilience in the mental health of harassment victims among pupils. This research used scoping method. The terms used include resilience, bullying, psychological wellness, and student. The observation of the article was conducted from 3 databases such as Scopus, PubMed and Science Direct. The article search includes student samples (from elementary to high school students) in English, title and abstract about resilience and bullying, and publications published within the previous five years (2020-2024), and innovative research. The grey literature was omitted from this scoping review. To analysis the data, authors selected thematic analysis method. There were thirteen papers about the topic. This studied materials' findings emphasize the complexities of the relationships between individual traits, resilience dimensions, social circumstances, and bullying characteristics. Strong level of resilience of students are more likely to respond positively to bullying and avoid developing mental health problems. Bullying victims' resilience is formed by several critical factors, including emotional control, social support, coping abilities, and self-competence. Social support is essential for building resilience and protecting against the effects of bullying. Intervention programs that involve emotional regulation skills, coping methods, and increased social support help minimize the impact and prevalence of bullying among child and adolescence. Improving understanding and abilities in resilience behavior can be a useful method for mitigating the bullying impact.
Effects of Hook Maneuver on Oxygen Saturation Recovery After ‒40 m Apnea Dive. A randomized Crossover Trial
Authors: DeAsís-Fernández Francisco , Reina-Varona Álvaro , Papotsidakis Evangelos , Lafuente Juan , Fierro-Marrero José
Published: December 2024

Background: To reduce the risk of syncope, trained breath-hold divers (BHD) use a specialized breathing technique after surfacing called “hook breathing” (HB). It consists of a full inspiration followed with a valsalva-like maneuver and with subsequent exhalation performed against resistance to generate continuous positive airway pressure during exhalation. Aims: This study analysed the influence of HB on oxygen saturation recovery after ‒40 m depth apnea dive in trained BHDs. Methods: Thirteen BHDs performed two dives to ‒40 m at different days, one followed by using HB after dive and the other using Usual Breathing (UB). To detect signs of lung edema, ultrasound B-line measurements were conducted before, 10-min after the dive and within 1 hour after the dive. To detect oxygen saturation recovery, pulse oximetry were recorded before, and immediately after surfacing. Results: Both groups exhibited significant increases in SpO₂ over time (UB: F(2.25, 24.7) = 22.1, p < 0.001, ηg2 = 0.612; HB: F(2.11, 23.2) = 29.0, p < 0.001, ηg2 = 0.688). Significant differences in SpO₂ were observed between the HB and UB groups at 30–45 seconds post-apnea, with higher SpO₂ values in the HB group. 4 participants showed ultrasound B-lines within ten minutes post-dive. Conclusion: After 40-m apnea dive, the results revealed significant SpO₂ recovery from 30 seconds to 45 seconds, with the HB recovering more rapidly. No differences were found at earlier (10-25 seconds) or later time points (50-60 seconds). Further evidence should explore this phenomena with larger sample sizes.
Oral Health as a Determinant in Preventing Cellular Aging and Promoting Immune Sustainability
Authors: Schick Fabian , Lechner Johann , Schulz Christian , Volz Karl Ulrich , Notter Florian , Schnurr Etyene
Published: December 2024

Background: This study assessed the effects of ceramic dental implant placement on inflamma-tory responses, immune function, and cellular aging in a 53-year-old female patient. Objective: This study aimed to determine whether minimally invasive implant procedures combined with regenerative techniques can influence biological aging and systemic inflammation. Methods: A comprehensive treatment approach was used, including minimally invasive ceramic dental im-plant placement, platelet-rich fibrin (PRF) augmentation, and vitamin supplementation. Advanced imaging and biomarker analyses have evaluated implant osseointegration, inflammatory pro-files, immune responses, and telomere length as markers of cellular health and aging. Results: Successful implant osseointegration was observed along with a favorable inflammatory profile, as reflected by increased levels of the anti-inflammatory cytokine IL-10. An improvement in telo-mere length suggests potential benefits to cellular health. However, a slight increase in biological aging was observed, as indicated by the glycan profile. These findings underscore the complex interactions between oral health, systemic inflammation, and biological aging. Conclusions: This study provides new insights into the regenerative and anti-aging potential of dental treatments, indicating that ceramic dental implants combined with regenerative therapies may reduce im-munological stress and support healthy aging. Although reduced inflammation and improved oral function are evident, the long-term effects on cellular aging and longevity remain unclear. Further studies are needed to better understand the impact of these interventions on biological aging and overall health.
Clinical Midline Shift Is Not a Predictor of the Side of Shorter Hemimandible. A CBCT Diagnostic Study
Authors: Pereira da Silva Ligia , López-Solache Alicia , Santana-Penín Urbano , López-Cedrún José , Mora María Jesus , Varela-Centelles Pablo , González-Mosquera Antonio , Rodríguez-Fernández Almudena , Santana-Mora Urbano
Published: December 2024

Background/Objectives: Interincisive midline deviation is frequent. Determining the cause (dental versus skeletal) is crucial for treatment planning. This study assessed the null hypothesis that neither clinical midline shift nor temporomandibular disorder (TMD)-affected side correlate with maxillary/mandibular asymmetry. Methods: Tomographic images were acquired using the i-CAT Imaging System; mandibular/maxillary measurements were obtained with the Planmeca Romexis software. This is an ancillary study of a clinical trial (NCT02144233) that included chronic pain (TMD diagnosis; DC/TMD criteria), fully dentate and stable normo-occlusion participants. Results: Thirty-eight CBCT scans were analyzed: 35 (92.1%) females, 3 (7.9%) males. Mean age 34.6 (11.9) years old. Sixteen (42.1%) midline deviations to the right and 13 (34.2%) to the left. In the study population the right side was more developed: hemimandible length 119.4 (5.7) mm versus 118.6 (5.3) mm, right and left sides, respectively (95% CI 0.21 to 1.51), p=0.01. Conclusions: Neither midline shift side nor affected side predicted a less developed hemimandible.
Calibration and Validation of the SWAT Model for Upper Bernam River Basin in Malaysia
Authors: Zakari Muazu Dantala , Rowshon Md Kamal , Ramli Norulhuda Binti Mohamed , Rehan Balqis Mohamed , Mohd Mohd Syazwan Faisal Bin , Kondum Franklin Aondoaver
Published: December 2024

Enhancing sustainable agricultural practices and water resources management calls for this study, which focuses on calibrating and validating the SWAT model using data from CMIP6. The SWAT model was validated using Bernam streamflow data from 1985-2022, divided into three categories: category 1 (10 years calibration- and 5 years validation), category 2 (15 years calibration- and 10 years validation), and category 3. The SWAT model performed "GOOD" in the Bernam watershed, as indicated by statistical analysis during calibration and validation phases, utilizing statistical indices. The results for the p-factor, r-factor, R2, NSE, PBIAS, and KGE were 0.82, 0.88, 0.72, 0.70, -1.1%, and 0.85 during the calibration period and 0.8, 1.04, 0.75, 0.65, -6.6%, and 0.79 during the validation period. The result of the simulation after adjusting the SWAT model parameters with calibrated best-fit values indicated that the inflow (rainfall) and the outflow (water yield + ET) are 2,873.36mm and 2,592.78mm respectively, with difference of 9.8% for the period of 1991-2005 while 2,921.98 mm and 2,586.07 mm for the inflow and outflow, during 2006-2020 period with difference of 11.5%. The SWAT model effectively predicts agro-hydrological processes, aiding decision-makers in UBRB's agricultural water management and guiding sustainable agriculture through advanced climate projections.
Ea8Mab-9: A Novel Monoclonal Antibody Against Erythropoietin-Producing Hepatocellular Receptor A8 for Flow Cytometry
Authors: Tanaka Tomohiro , Yamamoto Haruto , Kaneko Yu , Shinoda Keisuke , Nakamura Takuya , Li Guanjie , Fujisawa Shiori , Satofuka Hiroyuki , Kaneko Mika K. , Suzuki Hiroyuki , Kato Yukinari
Published: December 2024

Erythropoietin-producing hepatocellular receptor A8 (EphA8) is a type I transmembrane protein that belongs to the largest Eph family among receptor tyrosine kinases. By binding to its membrane-bound ephrin-A or ephrin-B ligands on adjacent cells, Eph receptors form complexes and mediate bidirectional signaling activities, triggering cell-cell adhesion and repulsion. Increased expression of EphA8 correlates with poor prognosis in some types of cancer. Therefore, developing sensitive monoclonal antibodies (mAbs) for EphA8 has been desired for treatment, diagnosis, and further basic research. In particular, there are no anti-EphA8 mAbs that can be used for flow cytometry. In this study, we established a novel specific and sensitive anti-human EphA8 mAb, which applies to flow cytometry, clone Ea8Mab-9 (mouse IgG1, kappa), by the Cell-Based Immunization and Screening (CBIS) method. Ea8Mab-9 reacted with EphA8-overexpressed Chinese hamster ovary-K1 cells (CHO/EphA8) and EphA8-overexpressed LN229 glioblastoma cells (LN229/EphA8) in flow cytometry. Ea8Mab-9 did not recognize other members of Eph receptors. Furthermore, Ea8Mab-9demonstrated a high binding affinity for CHO/EphA8 and LN229/EphA8 with dissociation constants of 1.3×10-9 M and 1.6×10-9 M, respectively. Ea8Mab-9, established by the CBIS method, could be useful for analyzing the EphA8-related biological response using flow cytometry with high affinity and specificity.
Simulated Herbivory Induces Volatile Emissions of Oak Saplings, but Parasitoid Communities Vary Mainly Among Forest Sites
Authors: Molleman Freerk , Mezzomo Priscila , Mandal Manidip , Volf Martin , Mallick Soumen , Moos Martin , Vodrážka Petr , Prinzing Andreas , Walczak Urszula
Published: December 2024

We know little about how parasitoids of herbivorous insects use herbivore-induced volatile organic compounds (VOCs) to locate potential hosts on saplings in forests and how this depends on tree composition. Therefore, we performed an experiment in a forest in Poland where we placed pairs of oak saplings (Quercus robur or Q. petraea) in neighborhoods dominated by oak, beech, or pine trees. We treated one sapling in each pair with the phytohormone methyl jasmonate that triggers induced responses in plants. We measured the VOC emissions of thirty-six saplings and placed Malaise traps with five of the pairs. We counted the parasitoids in the ten Malaise samples and identified them using DNA metabarcoding. The two species of oak differed in both the proportions of VOCs and the specific VOCs that were elevated following the application of methyl jasmonate. We did not detect any overall effects of treatment on parasitoid abundance or community composition. However, some parasitoid species appeared to be attracted to elevated emissions of specific induced VOCs. Parasitoid communities differed significantly between sites and showed marginally significant differences between neighborhoods. Overall, our results suggest that parasitoids in the understory are affected by tree composition of the canopy, but the effects of VOC emissions were limited.
Forest Disturbances Detection by Sentinel-2 Imagery in Isangi Territory, Democratic Republic of Congo
Authors: Varadarajan Jayasree , Balzter Heiko
Published: December 2024

In recent decades, there has been a significant transformation in global forests, characterized by widespread changes and disruptions, particularly in primary forest areas. The Isangi Territory in “the Democratic Republic of Congo” is one such deforestation hotspot, experiencing rapid forest disturbances. Various studies and government organizations have implemented systems that utilize satellite imagery to provide regular alerts on forest disturbances. However, the effectiveness of optical-based near-real-time monitoring methods is hindered by cloud cover in the humid tropics. To overcome these limitations, satellite missions that revisit an area more frequently have a higher chance of acquiring cloud-free images. The Sentinel-2 satellites presents a valuable opportunity for comprehensive global forest monitoring due to their high spatial resolution of 10 m and the frequent revisit time of 5 days. This study employs a maximum likelihood classification algorithm to map deforestation using Sentinel-2 satellite images from 2017 and 2022. The analysis is conducted at a spatial resolution of 10 meters, which enables enhanced disturbance detection in the tropical forest. The findings facilitate rapid change detection of forest disturbances, such as agricultural expansion and selective logging, within the study area. Sentinel-2 is hence a suitable source of satellite data for monitoring forest degradation in addition to deforestation.
Genome-Wide DNA Methylation Confirms Oral Squamous Cell Carcinomas in Proliferative Verrucous Leukoplakia as a Distinct Oral Cancer Subtype: A Case Control Study
Authors: Proaño Alex , Bagan Jose , Bagán Leticia , Sarrión-Pérez Gracia
Published: December 2024

Background/Objectives: Oral cancers in patients with proliferative verrucous leukoplakia (PVL-OSCC) exhibit different clinical and prognostic outcomes than conventional oral squamous cell carcinoma (cOSSC). The aim of the present study is to compare the genome wide DNA methylation signatures in fresh frozen tissues between oral squamous cell carcinomas in patients with PVL and cOSCC using the Illumina Infinium MethylationEPIC BeadChip. Methods: This case-control study was carried out at the Stomatology and Maxillofacial Surgery Department of the General University Hospital of Valencia. For the epigenomic study, unsupervised exploratory bioinformatic analyses were performed using principal component and heatmap analysis. Supervised differential methylation analyses were conducted using a rank-based regression model and a penalised logistic regression model to identify potential prognostic biomarkers. Results: The unsupervised analyses of the global methylation profiles did not allow to differentiate between the distinct oral cancer groups. However, the two supervised analyses confirmed the existence of two oral carcinomas phenotypes. We identified 21 differentially methylation CpGs corresponding to 14 genes. Among them, three CpGs had not been previously assigned to any know gene, and the remaining were associated with genes unrelated to oral cancer. The AGL, WRB and ARL15 genes were identified as potential prognostic biomarkers. Conclusions: This study emphasizes the significant role of epigenetic dysregulation in OSCC, particularly in cases preceded by PVL. We have provided data on differential methylation genes that could be involved in the molecular carcinogenesis of PVL-OSCC.
Effects of Silibinin on Delaying Aging in Drosophila melanogaster
Authors: Zhu Kai , Ni Hang , Hafeez Eqra , Hu Yaxuan , Hu Fan , Du Dongsheng , Chen Dongsheng
Published: December 2024

Aging is an inevitable physiological process, but delaying aging has always been an enduring human pursuit. Silibinin (SIL), derived from the seeds of the milk thistle plant, exhibits a broad spectrum of pharmacological properties, including anti-tumor effects, liver protection, inhibition of apoptosis, and alleviation of inflammation. However, whether it has anti-aging effects remains unclear. The SIL dietary supplement to Drosophila melanogaster prolonged lifespan, improved climbing ability, ameliorated age-associated intestinal barrier disruption, enhanced the resistance to oxidative stress, increased the enzyme activities of superoxide dismutase (SOD) and catalase (CAT). Furthermore, RNA-seq results showed that SIL-addition greatly upregulated 74 genes and downregulated 50 genes compared with the control. KEGG (Kyoto Encyclopedia of genes and genomes) analysis demonstrated that these differentially expressed genes were primarily involved in the Toll signaling pathway and endoplasmic reticulum proteins processing, six among which, including IM2, IM3, Drsl3, CG755, GCSL1 and TRAM, were particularly involved in the regulation by SIL supplementation. The results indicate that SIL exhibits anti-aging effects by enhancing antioxidant capacity and regulating aging-related signaling pathways. Therefore, SIL shows a potential application in anti-aging dietary regimens.
Methodology to Determine the Stress Distribution Based on Fatigue Data with Bilinear Behavior and Its P-S-N Field and Testing Plan
Authors: Monclova-Quintana Osvaldo , Piña-Monarrez Manuel R. , Hernández-Ramos María M. , Ortiz-Yáñez Jesús F.
Published: December 2024

In this paper, the method to determine the percentiles of the P-S-N field when it presents bilinear (s1 and s2) behavior (e.g competence failure mode) is given. The percentiles are determined around the Weibull scale (η) parameter in Cycles that corresponds to the median applied stress of the whole bilinear behavior. The reliability (R(t)) index that corresponds to each P-S-N percentile are also determined. As well as the confidence reliability percentile (CL) that corresponds to each P-S-N percentile. The formulation to relate CL with its corresponding normal P-S-N percentile is also given. Numerically, the percentiles of the normal (one, two, and three) sigma levels, as well as those that correspond to the capability Cp and Cpk indices are related with their CL values, and R(t) indices. To validate the Weibull cycle bilinear family, a test plan is designed and numerically performed. In the numerical application we use the 42CrMo4 steel material.
A Test Statistic for Identifying Jump Variations in High-Frequency Time Series
Authors: Tsay Ruey , Rojas Duran William Gonzalo , Morettin Pedro Alberto
Published: December 2024

We propose a test statistic that is useful to identify that increments in high-frequency time series data of prices follow a jump-diffusion model. The main result and contribution of this study shows that the distribution function of our proposed test statistic follows approximately a gamma distribution. This result is crucial because it enables us to determine the critical region for the rejection of the null hypothesis of interest. We show that the detection power and error rate of our proposed test statistic is better than a test statistic used as benchmark, showing a higher detection power and lower error rate. We applied our proposed test using high-frequency transaction prices of Google, Apple and Goldman Sachs stocks and found that our proposed test statistic captures the dynamics of the series.
Therapeutic Potential of Bovine Lactoferrin to Reduce Brain Malondialdehyde Levels in Hyperlipidemia-Induced Sprague-Dawley Rats
Authors: Telium Havian Daulung , Djuartina Tena , Notario Dion , Hananta Linawati
Published: December 2024

Hyperlipidemia is a medical condition that can trigger various diseases, one of which is a neurodegenerative or neurological disease. Lactoferrin is known to have multiple protective activities, one of which is antioxidant. This study aimed to determine the potential of lactoferrin bovine to decrease brain MDA levels in Sprague-Dawley (SD) rats induced by hyperlipidemia. This study was an in vivo experimental study using 24 male SD rats divided into six groups: normal, negative control, positive control, low-dose bovine lactoferrin (LLF), intermediate-dose bovine lactoferrin (ILF), and high-dose bovine lactoferrin (HLF). The diet in the normal group was the standard diet, and the other groups were induced by a high-fat diet (HFD). The intervention for the positive control group was simvastatin. In contrast, LLF, ILF, and HLF groups were given bovine lactoferrin doses of 100, 200, and 400 mg/kgBW, respectively. After seven weeks, all rats were necropsied, and their brains were taken to be tested for malondialdehyde (MDA) levels with an MDA assay kit using a spectrophotometer. Data was then analyzed using Shapiro-Wilk and Levene test and continued with one-way ANOVA and post-hoc Tukey test. There were significant differences (p<0.05) between the negative control group (269.99±13.50 nmol/g weight) and every bovine lactoferrin groups (219.92±22.99 nmol/g weight, 151.60±23.43 nmol/g weight, 158.16±12.33 nmol/g weight, respectively) in reducing brain MDA levels. In summary, all bovine lactoferrin groups (100, 200, and 400 mg/kgBW) significantly reduced brain MDA levels of SD rats in hyperlipidemia condition.
Tamanu Oil (Calophyllum inophyllum L.) Promotes Wound-Healing Activity in Alloxan-Induced Diabetic Rats, and Its Fatty Acids Profile
Authors: Rakhmawati Rita , Hadi Saptono , Ainurofiq Ahmad , Nugraheni Estu Retnaningtyas , Choiri Syaiful , Pratama Tiara Dewi Salindri
Published: December 2024

Diabetes Mellitus (DM) is a metabolic disease and is a severe threat because it causes diabetic wounds. Treating injuries in patients with DM is dominated by synthetic chemicals such as anti-inflammatory, corticosteroids, and antibacterial. It has side effects, so further exploration of natural ingredients is needed. One plant that has the potential to heal wounds is tamanu oil or nyamplung oil. This study aimed to investigate the effect of tamanu oil on the healing of diabetic wounds and the fatty acid composition profile. Male rats of the Wistar strain (Ratus novergius) were given incision wounds along a 2 cm depth of 2 mm, randomly divided into three groups, by applying topically twice a day. We are profiling fatty acids using gas chromatography-mass spectrometry (GC-MS). As far as we know, this is the first study showing that tamanu oil can speed up the healing of diabetic wounds in rats. The Tamanu oil containing oleic acid (42.65%), linoleic acid (25.69%), stearic acid (16.50%), and palmitic acid (12,93) had better effectiveness than other groups, demonstrated by wound closure exceeding 50% on day six and wound closure by 100% on day nine.