bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of microteaching as a tool to improve teaching skills among assistant professors in Medical College
Authors: Berad Aditya S. , C. Balakrishna
Published: February 2022

Background: Microteaching is a well-recognized tool for improvement of teaching skills. It scales down the complexities of real teaching, as immediate feedback can be sought after each practice session. The aim of the study was to evaluate the application of microteaching principles for improving teaching skills of Assistant Professors in medical college.Methods: Assistant Professors were asked to prepare a topic for tutorial lesson and engage one batches of II MBBS students (session I). The students assessed the performance of the Assistant Professors and gave immediate feedback to the faculty. The feedback focused on appreciating the good points and giving tips for improvement of group facilitation skills and teaching skills. The Assistant Professors then engaged another tutorial class on different topics (session II).Results: The results of the evaluation after two microteaching sessions showed that there was significant improvement in the teaching skills of the assistant professors. Lesson on the whole was effective.Conclusions: The teaching skills of assistant professors improved after the two sessions of microteaching. The faculty had more confidence in teaching after the study. Microteaching can be used as a tool to improve teaching skills among assistant professors in medical college.
Acute ischemic stroke in COVID19 pandemic: A single centre experience
Authors: Shah Shalin D , Patel Mayank A , Joshi Pranav B , Bhise Amey K , Patel Umang M , Shah Zubin A
Published: February 2022

Various neurological manifestations, including Acute Ishcemic stroke (AIS) has been described in association with SARS-CoV2 infection.

In a government-regulated tertiary care center of COVID 19, we did a retrospective analysis and found 7 patients of AIS in 4 months duration.

All patients were more than 50 yrs of age, were in moderate to severe COVID19 category and had pre-existing stroke risk factors. Four out of 7 patients developed stroke 7-10 days after onset of COVID19 symptoms. (Range 2-17 days). 71.4 % (5/7) had large artery ischemic stroke; two had multiple arterial territory involvement and two developed hemorrhagic transformations. Every patient had elevated levels of one or more inflammatory and/or prothrombotic biomarkers. The prognosis was poor, in terms of high mortality and morbidity.

Stroke mechanism in COVID19 may be multifaceted, varying from traditional atherosclerotic risk factors to large vessel thrombosis, embolism, prothrombotic state, coagulopathy, and/or vasculopathy.

More than one mechanism may operate in AIS with Covid19 infection and similar observation studies in heterogeneous populations will guide us to understand the disease process better and its therapeutic strategies.
Non-ketotic hyperglycemia presenting as acute hemiparkinsonism
Authors: Mathew Thomas , Hesarur Nagabushan , K John Saji
Published: February 2022

Non-ketotic hyperglycaemia is commonly associated with hyperkinetic movement disorders like chorea. Here we report a case of non-ketotic hyperglycaemia, in a 70 year old man with longstanding diabetes presenting as acute onset hemi-parkinsonism. Hypokinetic movement disorders are only rarely reported in non-ketotic hyperglycaemia.
Process analytical technology – A review of game changer regulatory framework by US FDA
Authors: Patel Adil
Published: February 2022

The concept of process analytical technology is introduced with the purpose of providing important information after the analysis of critical quality parameters which can have direct or indirect impact on the product quality. This type of information is helpful in maintaining the product quality while keeping the manufacturing cost low. The implementation of PAT will potentially improve the operational control and compliance as per regulatory guidelines for continuous real time quality assurance during manufacturing. The concept is relatively new for both academia and industry hence Considerable amount of study has been carried out to explore the various aspects of PAT guidelines and their successful implementation. This review mainly contains introduction and background of PAT guidelines as the first step in QBD implementation. Detailed understanding of analysis and selection of suitable analytical technique is the most important aspect of PAT guidelines. These analytical techniques will even play crucial role at the time of scale up and detailed evaluation of drug and dosage forms. The main purpose of this review is to understand the right perspective of PAT guidelines towards the goal of achieving products with highest quality.
Small round cell tumours of the sinonasal tract: Five years experience at a tertiary cancer institute in India
Authors: Pathak Tarali , Sarma Anupam , Das Rajjyoti , Singh Dhaneswor , Rahman Tashnin , Kataki Amal C
Published: February 2022

Sinonasal malignancies (SNM) constitute nearly 3% of Head & Neck cancers. Though rare, they still are one of the most challenging conditions to manage. Immunohistochemical (IHC) evaluation using relevant antibodies has become an indispensable ancillary technique for differentiating these tumours. An early and definitive diagnosis is important for optimally managing these aggressive tumours.

This study was done in the department of Head & Neck Surgery in association with department of Oncopathology of a tertiary Cancer Hospital in Northeast-India. Hospital records of all patients who received treatment for a sinonasal malignancy between the years 2013 to 2017 were retrospectively reviewed. Patients reported having a ‘Small round cell tumour’ in their initial histopathological examination (HPE) of biopsied tissue were included in the study.

The study included 31 patients of Sinonasal SRCT, nearly 38% of the total 81 patients diagnosed with a sinonasal malignancy during the study period of 5 years. The median age of these patients was 43 +/- 8 years (range 8-82 years). With a gender ratio of 1.6: 1 (M: F), SRCTs was found slightly commoner in males. Epistaxis and nose block (unilateral or bilateral) were the commonest symptoms. Mean symptom duration was approximately 3 months.

Establishing a precise diagnosis of Sinonasal SRCT is important not only in determining how aggressive the tumor might be, but is especially critical in deciding treatment modalities and their sequences. Immunohistochemistry plays an important role in proper histopathological diagnosis and further treatment planning.
Stromal luteoma in a case of multiple leiomyomatosis – A rare case report
Authors: Balaji S , Stephen Nortan , Gowndanay  , Hiremalth
Published: February 2022

Stromal luteoma of the ovary occurs mostly in postmenopausal females and is very rare. They account for 60% Abnormal vaginal bleeding is the most frequent presentation, but endocrine symptoms and sometimes virilizing signs may also be observed. This tumour is a close mimicker of Leydig cell tumour. However, the stromal location and the absence of Reinke’s crystalloids helps to confirm the diagnosis. This tumour is surrounded by an ovarian stroma, entirely composed of luteinized cells devoid of crystals of Reinke. We report an unusual case of a 41 year old female who presented with abdominal pain and menorrhagia. A TAH + BSO was performed and microscopy revealed a stromal luteoma of the right ovary with multiple intramural and subserosal fibroids. Preoperative diagnosis was a leiomyoma. However, microscopy revealed a stromal luteoma in the ovary. One third of the stromal luteomas are incidental findings. The preoperative and intraoperative diagnosis of this condition is challenging. Awareness about this condition among pathologists and clinicians may help in preventing misdiagnosis and overtreatment.
Canada-U.S. Relationship in the First Year of Biden’s Presidency: Expectations and Reality
Authors: Komkova Elena G.
Published: February 2022

The beginning of the Biden’s presidency caused inflated expectations in Canada, not all of which were destined to come true. 
The main event of 2021 in Canada-U.S. relations was the signing of a Roadmap for a Renewed U.S.-Canada Partnership, which was seriously damaged during the presidency of Donald Trump.
The past year has shown that J. Biden, like his predecessor D. Trump, is an economic nationalist committed to "Buy American", who is not inclined to make trade and economic concessions even to the closest allies.
Contemporary American Drama: Socio-Political Aspect
Authors: Khalilov Vladimir
Published: February 2022

The article deals with the topical issues of American drama based on the analysis of works by contemporary US playwrights, many of whom are representatives of groups classified as oppressed (in a white patriarchal society). The author examines popular topics and trends in cultural life in the context of public and political life in the United States over the past 70 years - from the Civil Rights Movement, "Women's Liberation" and Stonewall to "Black Lives Matter", "#MeToo" and LGBTQ prides. 
The author concludes that the current repertoire was directly influenced by the progressive agenda with its ambitious plan for large-scale social transformations that affected all cultural institutions, including theater. By highlighting the struggle for social equality and justice, the rights of blacks, women, ethnic and sexual minorities, diversity and inclusion, as well as condemnation of capitalism and American imperialism, progressivism has placed art at the service of ideology, once again turning cultural figures into 'engineers of human souls' - but also contributed to the expansion of opportunities for members of under-represented groups, integration, the development of intercultural dialogue and the emergence of new dramatic voices.
Desempenho produtivo do feijão-caupi em função da fonte e doses de N no sertão alagoano
Authors: Calheiros Altanys Silva , Silva José Pedro Da , Lima Fabrício José Rodrigues de Jesus , Silva Carlos Jorge da
Published: February 2022

O objetivo desse artigo é avaliar o rendimento produtivo e os teores e acúmulos de Nitrogênio (N) do feijão-caupi, cultivado com diferentes fontes e doses desse nutriente – N, no Município de Piranhas. Os tratamentos foram constituídos por duas fontes (mineral e orgânica), duas doses (40 e 80 kg ha-1) de N e por uma estirpe de rizóbio; também houve tratamentos com inoculação e adubação e um tratamento testemunha, dispostos em blocos casualizados com quatro repetições. A coleta de plantas para a avaliação de massa seca e de N foi realizada em pleno período de florescimento. Ao final do ciclo, foi avaliada a produção de grãos, amostrando-se áreas de 2,0 m2. Os valores médios das variáveis analisadas foram submetidos à análise de variância, e as médias comparadas pelos testes de Scott Knott a 5% de probabilidade. A estirpe de rizóbio foi que proporcionou o maior acúmulo de biomassa seca nas plantas, diferindo estatisticamente dos outros tratamentos. As maiores produções de grãos foram obtidas pelo tratamento inoculado e adubado com a dose de 40 kg ha-1 de N na forma orgânica. O esterco de curral pode ser uma viável fonte de N, de baixo custo, para a cultura do feijão-caupi, podendo ser utilizada pelos agricultores familiares da região semiárida de Alagoas em substituição ao N mineral.
Gerenciamento de risco de barragens do estado do Paraná: uma abordagem bibliográfica
Authors: Salibe Ariane Busch , Gobbi Andressa
Published: February 2022

O gerenciamento de risco de barragens identifica, avalia, trata e monitora riscos, tendo como objetivo minimizar ou mesmo eliminar a possibilidade de impactos negativos desse tipo de empreendimento na vida de pessoas e do meio ambiente. Neste estudo, uma revisão bibliográfica analítica foi realizada para identificar a classificação dos riscos das barragens do Paraná, Brasil, com base em uma análise quantitativa e qualitativa desses riscos e na análise do gerenciamento de segurança dessas barragens. Nas diversas literaturas encontradas, foram verificadas informações atualizadas sobre: fiscalização e classificação das barragens paranaenses realizadas por órgãos como o Instituto de Água e Terra (IAT), a Agência Nacional de Águas (ANA), a Agência Nacional de Energia Elétrica (ANEEL) e a Agência Nacional de Mineração (ANM); a existência de diversos métodos quantitativos e qualitativos que podem ser utilizados para determinar falhas em barragens, sendo a Análise dos Modos de Falha e seus Efeitos (Failure Mode and Effect Analysis – FMEA) a técnica que se destaca; e a identificação de práticas adequadas para um gerenciamento eficaz. Essa revisão possibilitou concluir que a identificação, classificação e fiscalização das barragens no estado do Paraná são realizadas pelo IAT, que apresenta relatórios anuais das condições das barragens para conhecimento público e segurança da população. Além disso, pode-se concluir que a aplicação de uma metodologia apropriada para análise de riscos é a forma mais adequada de prevenir uma catástrofe com possíveis perdas de vida.
Aplicabilidade dos softwares Artemis Views e Net Project na melhoria do processo de execução de obras públicas
Authors: Ercan Luana Maris Pedrosa Cruz , Oliveira Wesley Silva de , Condé Laura Fernanda De Oliveira Silva , Oliveira Danielle Meireles de , Bremer Cynara Fiedler , Ribeiro Maria Carmen Couto
Published: February 2022

Este trabalho tem como objetivo avaliar a aplicabilidade dos softwares de gerenciamento Artemis Views e Net Project no planejamento e no controle de obras públicas. Nesse sentido, a perspectiva priorizada centra-se na importância da compatibilidade dessas ferramentas com o projeto a ser executado, a fim de serem minimizados riscos e otimizado o processo da construção, atentando-se à Lei de Licitações nº 8.666/1993. Para tanto, procedeu-se a uma pesquisa sobre os requisitos necessários para o planejamento e o controle de obras públicas, segundo as diretrizes estabelecidas pela Norma de Desempenho ABNT NBR 15.575/2021. Ademais, este estudo foi realizado com base na análise da aplicação de ações preventivas e corretivas fornecidas pelos softwares de gerenciamento Artemis Views e Net Project, visando atender às diretrizes legais estabelecidas pela Lei de Licitações nº 8.666/1993. Os resultados obtidos demonstram viabilidade na adoção de softwares com o objetivo de diminuir perdas de materiais e aumentar o rendimento na utilização de recursos públicos. A análise fornece, ainda, evidências de que uma efetiva integração de projetos, recursos e processos de planejamento amplia o desempenho e a eficiência no emprego de materiais, promovendo a sustentabilidade em obras públicas.
Carbonatação e penetração de cloretos em compósitos cimentícios com incorporação de lodo de estação de tratamento de água
Authors: Hemkemeier Thiago Alex , Rezende Mariana De Almeida Motta , Dal Ri Carla Signori , Sales Almir
Published: February 2022

O descarte inadequado de lodo de estação de tratamento de água (LETA) em corpos d’água é um problema ambiental que preocupa os gestores de cerca de 7.500 estações de tratamento de água das cidades brasileiras. No presente artigo o LETA foi tratado em laboratório e utilizado em substituição parcial à areia natural na proporção de 3% em massa para produzir um novo compósito cimentício. Esse compósito cimentício foi avaliado em relação a alguns requisitos de durabilidade (carbonatação e penetração de cloretos). Para avaliar a profundidade de carbonatação e a penetração de cloretos nos compósitos cimentícios, foi utilizado o método colorimétrico, com solução indicadora da penetração de gás carbônico e solução de cloreto de sódio, respectivamente. Em relação a um compósito cimentício convencional (sem LETA), o compósito com LETA apresentou comportamento similar, podendo ser recomendado para fins estruturais no que se refere à profundidade de carbonatação e à penetração de cloretos.
Dimensionamento de vigas protendidas contínuas pelo método das cargas equivalentes
Authors: Lanini Tamiris Luiza Soares , Arroyo Felipe Nascimento , Carvalho Roberto Chust , Christoforo André Luis , Almeida Filho Fernando Menezes de
Published: February 2022

O concreto protendido objetiva reduzir ou anular os efeitos de tração (fissuração) em um elemento de concreto. Considerando elementos isostáticos, o equacionamento e o cálculo consideram a adição de um momento fletor oriundo da aplicação do esforço de protensão a uma excentricidade do centro de gravidade da peça. Todavia, em estruturas hiperestáticas, o equacionamento e o cálculo são mais complexos, pois há consideração dos hiperestáticos de protensão oriundos da restrição do deslocamento no apoio. Portanto, é usual a representação pela superposição de efeitos de um sistema isostático protendido sob os efeitos dos esforços hiperestáticos oriundos da protensão. Entre as metodologias de cálculo existentes, tem-se o método da carga equivalente convencional proposto por Lin (1963). Nesse contexto, o presente estudo objetivou apresentar as considerações da literatura referentes ao momento hiperestático de protensão considerando esse método, em que foi calculada a armadura de protensão no estado limite último de uma viga protendida contínua, proposta por Kuchler (1993). Para tanto, apresenta-se também a determinação das perdas de protensão imediatas e ao longo da vida útil no cabo equivalente considerado. Ao final, a armadura de protensão obtida se assemelha ao exposto por Kuchler (1993), atestando a veracidade da metodologia empregada.
Creating Awareness Regarding Forensic Odontology Among Non-Forensic Persons for Successful Dental Identifications
Authors: Pandey H. , Nuzzolese E.
Published: February 2022

Visual Identification by next of kin is the most common method of identifying unknown bodies in India. However, this technique is unscientific and unreliable, especially if the remains recovered are decomposing, skeletonized, charred, mutilated, saponified. Primary identifiers recommended by higher authorities for scientific identification of unknown bodies include comparison of fingerprints, DNA, odontology or unique medical records such as implants. Forensic Odontology has played a major role in identifying victims of mass disasters around the world, and few examples of successful application of dental data in DVI situations include the South Asian Tsunami, 2004, Black Saturday bushfires, 2009, Australia, Christchurch earthquake, 2011, etc. However, the application of forensic odontology for positive identifications is extremely limited. A major reason for this is the unavailability and inaccessibility to quality dental records and ante mortem data. To improve the collection of ante mortem data, it is urgent that we create awareness among local on-ground investigating agencies, and stakeholders. For this purpose, an awareness campaign iDENTifyme from the University of Turin, Italy was launched in India in local languages, and has since successfully assisted in collection of ante mortem data for positive identification.
To Evaluate the Sensitivity of ABO Antigen Determination from Dental Pulp at Various Temperatures over a Duration of 3 Months - A Diagnostic Study
Authors: Nazir Humaira , Mahadesh Jyothi , Laxmidevi B. L. , Gopinathan Pillai Arun , Chatterjee Ananjan , L. Pradeep
Published: February 2022

Introduction: Every individual either living or dead has an unique identity as per theory of uniqueness. Medico legal examination recognizes the blood group as an unique indicator as it remains unchanged, forensic study uses teeth as the unique biological indicator, as they are the least destructible part of the body.. The present study was conducted to evaluate the efficacy in retrieving ABO blood group antigens from pulp tissue at various temperatures like freezing temperature, 100°C and 200°C with room temperature being the baseline for the study and at various time intervals (same day, 14th, 30th and 90th day) post extraction by adsorption –elution method. Materials and Methods: A diagnostic study of 80 cases was included which involved extraction procedures under local anesthesia following the aseptic protocol. Sterile cotton/gauze was compressed in the socket and later the blood collected from it served as a control group for the study. The extracted teeth were washed and kept, stored in numbered bottles for different time periods after being subjected to different degrees of temperatures i.e. at room temperature, freezing temperature, 100°C and 200°C for 60mins respectively. Results: Goodman Kruskal Gamma test was used for statistical analysis to obtain the correlation between blood groups at different temperatures. After analyzing the ABO antigen for sensitivity at various degree of temperature over different time intervals it was found that at freezing temperature and room temperature, antigens can be assessed , while at higher temperatures it is difficult to appreciate. Conclusion: Adsorption-Elution technique can be used as a reliable tool for determination of ABO blood group from the dental pulp of deceased person.
Slow pyrolysis of cork granules under nitrogen atmosphere: by-products characterization and their potential valorization
Authors: Costa Paula A. , Barreiros M. Alexandra , Mouquinho Ana I. , Oliveira e Silva Pedro , Paradela Filipe , Oliveira Fernando A. Costa
Published: February 2022

Cork granules (Quercus suber L.) were slowly pyrolyzed at temperatures between 400-700 °C and under N2 flow. While preserving its structure, some cells of the cork biochar became interconnected, allowing such carbon residue to be used as templates for manufacturing ceria redox materials. The pyrolytic char morphology was similar to that of the natural precursor. The produced cork biochar belonged to Class 1 (C > 60%) and possessed a high heating value of 32 MJ kg−1. Other pyrolysis-derived compounds were identified and quantified through GC-FID and GC-MS analyses. The yield of gases released during cork pyrolysis was strongly dependent on the temperature used due to the thermal decomposition reactions involved in the degradation of cork. In particular, rising pyrolysis temperature from 500 to 700 ºC resulted in reducing the total hydrocarbon gases from 74 to 24 vol%. On the other hand, the yield of H2 increased from 0 to 58% by increasing the pyrolysis temperature from 400 to 700 ºC. Due to the presence of suberin in cork, the composition and yield of bio-oil could be regulated by the pyrolysis temperature. Cork bio-oil was found to consist of long-chain hydrocarbons (from C11 to C24). The bio-oil resulting from the slow pyrolysis of cork residues is suitable as an appropriate feedstock for producing aliphatic-rich pyrolytic biofuels or as a source of olefins. Overall, the findings of this study suggest that Quercus suber L. could be a promising feedstock for biochar and biofuel production through the pyrolytic route and could contribute to the environmental and economic sustainability of the cork production industry.
Exergy sustainability analysis of biomass gasification: a critical review
Authors: Shahbeig Hossein , Shafizadeh Alireza , Rosen Marc A. , Sels Bert F.
Published: February 2022

Biomass gasification technology is a promising process to produce a stable gas with a wide range of applications, from direct use to the synthesis of value-added biochemicals and biofuels. Due to the high capital/operating costs of the technology and the necessity for prudent management of thermal energy exchanges in the biomass gasification process, it is important to use advanced sustainability metrics to ensure that environmental and other sustainability factors are addressed beneficially. Consequently, various engineering techniques are being used to make decisions on endogenous and exogenous parameters of biomass gasification processes to find the most efficient, viable, and sustainable operations and conditions. Among available approaches, exergy methods have attracted much attention due to their scientific rigor in accounting for the performance, cost, and environmental impact of biomass gasification systems. Therefore, this review is devoted to critically reviewing and numerically scrutinizing the use of exergy methods in analyzing biomass gasification systems. First, a bibliometric analysis is conducted to systematically identify research themes and trends in exergy-based sustainability assessments of biomass gasification systems. Then, the effects of biomass composition, reactor type, gasifying agent, and operating parameters on the exergy efficiency of the process are thoroughly investigated and mechanistically discussed. Unlike oxygen, nitrogen, and ash contents of biomass, the exergy efficiency of the gasification process is positively correlated with the carbon and hydrogen contents of biomass. A mixed gasifying medium (CO2 and steam) provides higher exergy efficiency values. The downdraft fixed-bed gasifier exhibits the highest exergy efficiency among biomass gasification systems. Finally, opportunities and limitations of exergy methods for analyzing sustainability aspects of biomass gasification systems are outlined to guide future research in this domain.
ФІНАНСОВА БЕЗПЕКА ПІДПРИЄМСТВ В УМОВАХ ЦИФРОВОЇ ЕКОНОМІКИ
Authors: Мехед А. М. , Варналій З. С.
Published: February 2022

Метою статті є дослідження впливу цифровізації на діяльність підприємств та організацію системи їхньої фінансової безпеки, зокрема сформувати визначення фінансової безпеки як структурної компоненти економічної безпеки в контексті цієї роботи, окреслити переваги та виявити проблеми функціонування підприємств в умовах цифрової економіки та сформувати теоретичні положення розробки механізму фінансової безпеки, адаптовані до умов цифрового середовища. Наведено авторське визначення поняття фінансової безпеки як міри гармонізації в часі і просторі економічних інтересів підприємства з інтересами суб’єктів зовнішнього середовища з метою формування відповідної системи для захисту фінансових інтересів підприємства від наявних і потенційних внутрішніх і зовнішніх загроз. Досліджено сутність цифрової економіки як нової парадигми розвитку економіки і суспільства, де основним фактором виробництва є інформація, представлена в цифровому варіанті. Визначено характерні риси цифрової економіки, а також позитивні та негативні аспекти, які мають вплив на безпеку підприємницьких структур. Визначено сутність і роль системи фінансової безпеки підприємства в умовах діджиталізації економіки та сформовано основні положення розробки механізму фінансової безпеки, адаптовані до умов цифрового середовища. При цьому до результатів функціонування механізму фінансової безпеки підприємства в умовах цифрової економіки віднесено: забезпечення сталого розвитку в мінливих умовах; збільшення позитивних грошових потоків; створення і використання сучасних ІТ-систем та бізнес-моделей; формування високого рівня управління і швидкого реагування на загрози. Своєю чергою, забезпечення фінансової безпеки підприємства в умовах цифрової економіки повинно базуватися на таких принципах: системність; оперативність реагування на загрози; безперервність здійснення заходів; узгодженість рішень і дій; доцільність витрат на заходи безпеки; компетентність управлінського персоналу та працівників компанії; послідовність у проведенні заходів; спрямованість на результат.
Antiproliferative activity of an angular furanocoumarin-oroselol in human oral cancer cells is mediated via autophagy induction, inhibition of cell migration, invasion, and downregulation of PI3K/AKT signalling pathway
Authors: Wang Yangyang , Liu Rui , Meng Fanli , Su Zhejun
Published: February 2022

Oral carcinoma is a lethal type of cancer associated with huge morbidity and mortality. Oral cancer patients show a very low survival chances even if diagnosed at early stages. The need for novel naturally occurring chemotherapeutic drugs increases due to high cost and toxicity of currently used clinical drugs. Present study was designed to investigate anticancer property of oroselol, keeping in view the medicinal potential showed by coumarin subclass furanocoumarins. MTT assay and clonogenic assays were implemented for viability assessments. Transmission electron microscopy was used for autophagic studies. The transwell chambers assay was used to investigate the migration and invasion. Western blotting was performed to determine the expressions levels of autophagy and PI3K/AKT signalling related proteins. Results showed that oroselol could potentially inhibit viability of oral cancer SSC-4 cells in time- and dose-reliant fashion. The antiproliferative effects were mediated through autophagy induction as indicated by formation of autophagosomes and enhanced LC3-l expressions and reduced LC3-II and p62 expressions. Cancer cell migration and invasion was potentially supressed by oroselol cell treatment. The PI3K/AKT signalling pathway was blocked potentially by oroselol in SSC-4 cells which showed reduced phosphorylation of PI3K and AKT. In conclusion, oroselol holds a significant potential to induce autophagy-related antiproliferative effects along with inhibition of cell migration, cell invasion, and PI3K/AKT signalling pathway. Therefore, oroselol may prove to be a lead molecule in oral cancer chemotherapy provided further in vivo and toxicological studies are performed on it.
Risk-Return Trade-off and Volatility Characteristics in the Indian Stock Market
Authors: Tamilselvan Manickam , Palamalai Srinivasan , Kumar Magesh , Aswathaman Jayakumar , Veerabhadrappa Manjula
Published: February 2022

The study examines the volatility characteristics of Indian stock markets and their tradeoff between the risk and return. It finds a positive but insignificant association between the risk and returns during the subsample (the pre-COVID and COVID pandemic outbreak) and whole sample periods. The study also shows that the weak form of Indian stock markets is not sustainable. Consistent with the GARCH literature, persistent and asymmetric effects are evidenced, and the magnitude of the negative shocks has a larger immediate impact than the positive shocks. These results would help measure the volatility in the Indian stock markets and provide investors and regulators with necessary information about the market efficiency, persistency (long-memory process) and asymmetric effects.
The relationship between smoking dependence, exposure to cigarette smoke, carboxyhemoglobin and perioperative complications in patients who underwent laparoscopic cholecystectomy under general anesthesia
Authors: EMİNOGLU Şermin , OZGUNAY Seyda Efsun
Published: February 2022

Objectives: The aim of this study; to determine the effects of preoperative smoking dependence and noninvasively measured carboxyhemoglobin (COHb) levels on perioperative complications in patients who underwent elective laparoscopic cholecystectomy.
Methods: Ninety patients (Group I: smoker, Group II: non-smoker, and Group III: passive smoker) who underwent laparoscopic cholecystectomy under general anesthesia were studied. The level of dependence of smokers was evaluated with the Fagerstrom Test for Nicotine Dependence (FNBT). Preoperative COHb level was determined with a pulse CO-oximeter by placing a sensor on the fingertip. Respiratory complications in the perioperative and recovery room and Modified Aldrete Score (MAS) in the recovery room were recorded as 5th, 10th and 15th min.
Results: Female gender was significantly higher in Groups II and III. Significant increases were noted in Group I in terms of increased perioperative secretion and incidence of bronchospasm. In the recovery room, the increase in MAS 5th min in Group I and MAS 10th min and 15th min in Group III was significantly lower. In Group I, positive correlations between the COHb level and the number of cigarettes smoked and the FNBT level, and a negative correlation between MAS and the number of hours past after the last cigarette smoked were determined. In Group II, the COHb level correlated positively with the number of cigarette smokers at home and negatively with MAS. All these correlations were statistically significant.
Conclusions: It was demonstrated that cigarette smoking increased the incidence of perioperative respiratory complications under general anesthesia. Preoperative COHb level estimated by the pulse CO-oximeter can be used as an indicant of the potential risk of perioperative repiratory complications.
The Importance of Feedback in Contemporary Education
Authors: Manole Ionut-Constantin
Published: February 2022

Our study aims to create an analysis, from the following perspectives: pedagogical, philosophical and informatics on the feedback in the contemporary education. Feedback is the mean by which the teacher can receive opinions about the activity or something he has done. This is very important for the person receiving it to improve their future performance. Given that, in contemporary society, courses can also be conducted online, and it is difficult in some scenarios for teachers to receive feedback from students. That is why it is so important for students to think about how teachers are conducting the educational act. Teachers generally don’t tend to ask students for feedback, even if this would have been beneficial in the act of teaching-learning, as they relied on the fact that they could physically follow them during classes. The bench position, the students' facial expressions and gestures were essential signals for the teachers, who helped them to adapt. However, in contemporary society many students do not interact in video and audio during classes, it is very difficult for teachers to observe from their attitude what they understood and what they did not. So the solution would be to opt for alternative methods of obtaining feedback.
Znikające różnice. Relacje między socjologią i antropologią kulturową w świetle teorii systemów Niklasa Luhmanna
Authors: Woroniecka Grażyna , Łukasiuk Magdalena
Published: February 2022

Artykuł stanowi wprowadzenie do tomu „Przeglądu Socjologii Jakościowej” poświęconego socjologii i antropologii w ich wzajemnych relacjach. Obie dziedziny zostały w nim opisane jako systemy komunikacyjne w perspektywie teorii Niklasa Luhmanna, by za pomocą przywołanej w ten sposób pojęciowości oraz mechaniki procesów systemowych ująć w perspektywie diachronicznej problem granic obu dziedzin. Autorki pokazują na przykładach tekstów konstytutywnych dla socjologii i antropologii, jak wyróżnicowywały się one, domykały i zaznaczały swoje granice, by później – głównie ze względu na zwielokrotnione i niejednorodne odniesienia do środowiska – nie być w stanie ich utrzymać.
Zwrot lingwistyczny a samorefleksyjność antropologii
Authors: Walczak Bartłomiej
Published: February 2022

W okresie „zwrotu lingwistycznego” zakwestionowano modernistyczną ideę badacza jako transparentnego podmiotu poznania, co otworzyło drogę do krytycznej analizy antropologicznego dyskursu i sposobu rekonstruowania w nim epistemologicznego doświadczenia antropologa. Analiza krytyczna nie okazała się celem samym w sobie, ale przyczyniła się do wytworzenia refleksji nad rolą badacza i w konsekwencji do wypracowania podejścia uwzględniającego ontoepistemologiczne ograniczenia w badaniu. W artykule zostaje podjęta analiza wybranych elementów tej krytyki, w szczególności „realistycznego” dyskursu modernistycznej antropologii oraz rekonstruowania obrazu pola badawczego zgodnie z transkulturowymi i lokalnymi strukturami pojęciowymi. Nowa krytyka, pokazując uwikłanie badacza jako podmiotu poznającego, jednocześnie powoli wprowadziła „tubylca”, podmiot badany, jako równorzędnego partnera w dyskursie. Ta zmiana, która zajęła antropologii ponad trzydzieści lat, staje się punktem wyjścia dla rozważań nad wartością omawianych elementów antropologicznej refleksji dla analizy doświadczeń epistemologicznych w socjologii.
АЛГОРИТМ УПРАВЛЕНИЯ СИСТЕМОЙ АЛМАЗНОГО БУРЕНИЯ
Authors: Нескоромных Вячеслав Васильевич , Попова Марина Сергеевна , Зотов Захар Геннадьевич , Баочанг Лиу
Published: February 2022

Ссылка для цитирования: Алгоритм управления системой алмазного бурения / В.В. Нескоромных, М.С. Попова, З.Г. Зотов,  Лиу Баочанг // Известия Томского политехнического университета. Инжиниринг георесурсов. – 2022. – Т. 333. – № 2. – С. 81-89.

Актуальность. Из всех известных способов проходки скважин алмазное бурение отличается высокой частотой вращения инструмента на больших глубинах. Такие условия разрушения горной породы требуют особого контроля параметров процесса бурения и их корректировки в случае нарушения баланса системы реализуемых сил. Все параметры процесса бурения в определенной степени взаимосвязаны. Для достижения наибольшей эффективности работы алмазного породоразрушающего инструмента требуется оптимальный механизм его эксплуатации. Анализ ситуации и подбор нужных показателей режима бурения алмазным инструментом довольно трудоемкая работа, которую в производственных условиях необходимо осуществлять непрерывно онлайн, поэтому актуальной является задача разработки автоматизированной системы управления процессом алмазного бурения с целью рациональной организации использования дорогостоящего алмазного инструмента. Автоматизация управления бурением осуществима путем применения современных технологий компьютерного программирования, алгоритм которого должен учитывать все требования оптимизации взаимозависимых параметров процесса бурения. Целью исследования является разработка алгоритма управления системой алмазного бурения для дальнейшего внедрения его в программное обеспечение.Объекты: процесс алмазного бурения скважин, технико-экономические показатели бурения и параметры, оказывающие влияние на результаты бурения. Методы: аналитический метод, метод полного факторного эксперимента, метод моделирования. Результаты. Основными параметрами, влияющими на итоги проводимых буровых работ, являются механическая скорость бурения, ресурс инструмента и мощность, затрачиваемая на разрушение горной породы. Использование в качестве критерия оптимальности величины углубления за оборот позволяет обеспечить приемлемую скорость бурения и низкие затраты мощности при сохранении высокого ресурса инструмента. Процесс управления алмазным бурением заключается в анализе изменения в конкретный момент времени механической скорости бурения и мощности, на основании которого принимается решение о корректировке величины частоты вращения и осевой нагрузки. Разработан алгоритм управления системой алмазного бурения, который может быть реализован доступным языком программирования.
​​Genetic Diversity Analysis for Bacterial Leaf Blight Disease Resistance in Rice (Oryza sativa L.)
Authors: Jerish J.R. , Narayanan R. , Murugan S.
Published: February 2022

Background: Rice (Oryza sativa L.) gets affected by more than seventy diseases by the infection of bacteria, fungi and viruses. Among, bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv oryzae (Xoo) is the important disease around the rice cultivated areas and causing drastic yield losses ranging between 20 and 30 per cent. Among very few options for increasing yield potential in rice, genetic diversity among the genotypes plays an important role in selection of parents having wider variability for disease resistance. Methods: The rice genotypes were screened using PDI for bacterial leaf blight (BLB) and subjected to D2 analysis for nine quantitative traits viz., plant height, number of productive tillers per plant, panicle length, days to fifty per cent flowering, number of grains per panicle, thousand grain weight, grain length, grain breadth and single plant yield. Result: On the basis of Mahalanobis D2 statistics, the thirty five genotypes are grouped into VIII clusters. The highest intra cluster distance was recorded for cluster II (41.16) followed by cluster VI (37.73). Out of thirty five genotypes screened under field condition using percentage disease index (PDI), CR 1009 found to be resistant with the lowest PDI value of 9.67 per cent. The genotypes Karsamba, TPS 4 and Kaivara samba registered highest PDI value of 70.67, 67.22 and 66.67 respectively. The BLB resistance in genotype dependent and not cluster based. The resistant genotype CR 1009 under field screening was positioned in VI cluster. The cluster II had susceptible genotypes karsamba and kaivarasamba. Thus, the identified genotypes can be utilized in recombination breeding to provide BLB resistance segregants.
Long-term Feeding Effects of Calcium-bentonite Clay in Aflatoxin B1 Contaminated Diet on Egg Production, Egg Quality and Immune Status of Laying Hens
Authors: Khamphong E. , Bunchasak C. , Poungpong K. , Prasongsook S. , Poeikhampha T.
Published: February 2022

Background: This experiment was conducted to determine the effect of synthetic aflatoxin B1 and calcium bentonite clay as a mycotoxin binder in the laying hen diet on performance, egg quality and immune response to vaccination.
Methods: A total of 144 Lohmann brown classic hens (22 weeks old) were divided into 4 groups of 6 replications with 6 hens each. This experimental design was completely randomized design and there were 4 experimental diets: (1) Basal diet (Positive control), (2) Basal diet +0.25% calcium bentonite clay, (3) Basal diet+200 ppb aflatoxin B1 (negative control) and (4) Basal diet+200 ppb aflatoxin B1 and +0.25% calcium bentonite clay. All hens were vaccinated with Newcastle (ND) and Infectious bronchitis (IB) vaccines during 24 weeks feeding trial.
Result: At the end of the 24 weeks of feeding trial, dietary treatments did not influence the egg production, egg mass, feed conversion ratio (FCR) and IB titer of hens; however, aflatoxin B1 significantly (P less than 0.05) deceased final body weight and deceased the eggshell color score (P less than 0.05). Moreover, the ND titer was reduced by aflatoxin B1 at 8th and 12th weeks of trial (P=0.05 and less than 0.05; respectively). Thus, supplementation of 0.25% calcium bentonite clay in feed improved body weight, eggshell color and ND titer of laying hens similar to those fed the positive control diet.
Analisis Dinamik Model Penyebaran Tumor Otak dengan Respon Sel Imun
Authors: Anggraini Resti Dwi , Pagalay Usman , Nashichuddin Achmad
Published: February 2022

The brain tumor distribution model with immune cell response is in the form of a non-linear system of ordinary differential equations with five equations. Each equation describes how immune cells in the brain, namely macrophages ( ), CD8+ T cells ( ), TGF-  cytokines ( ) and IFN-  ( ) cytokines interact with tumor cells, namely glioma cells ( ). From the calculation of the equilibrium point, the tumor cell-free conditions (DFE) and the endemic conditions (END) were obtained, in which tumor cells in long-term conditions were always present in the patient's brain. By using certain parameter values, it can be illustrated that the END condition is locally asymptotically stable while the DFE condition is locally unstable. This indicates that brain tumor cells, namely glioma cells ( ) will increase to their maximum value of 882650 cells and remain at that number from day 1000 onwards.
Educating Mental Health Nurse Practitioners on Interprofessional Collaboration and Preparing Them for Collaborative Practice
Authors: Haefner Judy , Filter Marilyn
Published: February 2022

Background

Although interprofessional collaboration (IPC) has been discussed for over 40 years, in nursing education as well as the majority of health professionals, education continues to primarily take place in silos with curricula that is discipline specific. Educators need to implement models of education that are linked to collaborative practice and team-based care.

Objectives

To introduce the principles from the Core Competencies for Interprofessional Collaborative Practice, the American Association of Colleges of Nursing Essentials of Doctoral Education for Advanced Nursing Practice and the National Organization of Nurse Practitioners Faculties Nurse Practitioner Core Competencies into the coursework. To demonstrate an application process for incorporating collaboration in their future nurse practitioner roles.

Method

Students in the Doctor of Nursing Practice mental health nurse practitioner program participated in a set of assignments to develop essential knowledge and skills for integration of IPC into practice. A pretest–posttest design was used to evaluate student attitudes towards IPC following immersion in IPC subject matter and experiential learning with other healthcare providers working together to coordinate patient care.

Results

There were significant findings for six of the 18 survey questions. This project can serve as an example for successful implementation of IPE in the nursing curricula.
Multifocal Bullous Fixed Drug Eruption
Authors: Oliveira Carolina , Rodrigues Maria Alexandra , Cunha Velho Glória
Published: February 2022

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The corporate social responsibility policy in the fulfillment of facilities for workers with disability
Authors: Gde Wiryawan I Wayan
Published: February 2022

The issue of people with disabilities or people who have different abilities is now known as "diffable" (differently-abled people) or now known as "disability" is a problem that on a practical level rarely gets the attention from the government, companies and community. In fact, the international community really appreciates and respects the protection of the human rights of persons with disabilities. This can be seen in the Convention on the Rights of Persons with Disabilities which is an international agreement on the protection of the rights of persons with disabilities. This international agreement was adopted on 13 December 2006 at the United Nations Headquarters in New York and opened for signature on 30 March 2007. Indonesia itself has signed the Convention on the Rights of Persons with Disabilities on 30 March 2007 and ratified on 30 November 2011. The implication is that the state is obliged to guarantee the fulfillment of the right of people with disabilities to find work. The rights for persons with disabilities do not only end there but also include the right to have a work area that is friendly to persons with disabilities. To fulfill these rights, companies are expected to implement corporate social responsibility policies. Corporate social responsibility is a business commitment to act ethically, operate legally and contribute to economic development along with improving the quality of life of its workforce. In this study, it will be discussed how the formulation of corporate social responsibility in the laws and regulations in Indonesia and how to fulfill facilities for disabled workers within the framework of corporate social responsibility policies.
Judicial pardon as perfection of the implementation of legality principle in sentencing
Authors: Aries Albert
Published: February 2022

For more than 75 years of enactment of the Dutch Criminal Code (KUHP), the legality principle contained in Article 1 Paragraph (1) of the Criminal Code is applied rigidly in Indonesia. This rigidity is now perfected with the model of the Judicial Pardon which can be imposed after examination and proof that leads to the conclusion that the defendant is legally and convincingly proven guilty of committing the crime charged by the Public Prosecutor. However, because there are several basic considerations as guidelines for sentencing, namely the lightness of the act, the personal circumstances of the perpetrator, the circumstances at the time of the commission of the crime, the aftermath, and incapacity that can be forgiven, as well as aspects of humanity and justice, grant judges the authority not to impose a crime or impose action against the defendant, so that the decision model perfects the principle of legality in modern sentencing, and is expected to solve the problem of the excess number of inmates from prisons. This research was conducted using the normative legal research (qualitative legal research) method by conducting a juridical study of data sources originating from the legal principles contained in the Criminal Code of several countries. This research is expected to find clearer arrangements and formulations of dictum decisions for fair legal certainty.