bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficiency studies of the sharia insurance industry: A systematic literature review
Authors: Alam Azhar , Tri Ratnasari Ririn , ‘Ainul Qolbi Fikri , Hanif Noor Athief Fauzul
Published: December 2022

The sharia insurance industry has experienced significant development from year to year. A sharia insurance company’s efficiency is crucial because it reflects its capacity to generate outputs from resources. This study aims to enhance comprehension of the efficiency of sharia insurance currently studied by doing a comprehensive literature study. This study selected 429 published articles about Islamic insurance indexed by Scopus between 2010 and 2022. 32 final articles that met the criteria that discussed efficiency as the primary study included in the qualitative synthesis analysis were selected. As a result, this study succeeded in revealing the development of sharia insurance efficiency studies based on the number of publications, authors, countries, subject areas, sources of publications, and cited articles. The study found four main methods researchers used to measure the efficiency of Sharia insurance. This study also revealed several studies comparing the efficiency level between conventional and sharia insurance. Furthermore, the study’s results were mapped based on the significance of the influence of variables on the efficiency of Sharia insurance. This study offers a new opportunity for further development in methods and variables of the efficiency of sharia insurance.
Knowledge map of digital tourism: A bibliometric approach using CiteSpace
Authors: Luo Chen , Jiang Songyu , Pu Ruihui , Li Lin , Yang Hongmei
Published: December 2022

Digital tourism is an essential product of the digital economy, which is significant in promoting sustainable tourism. The study aims to analyze the current research status of digital tourism with the CiteSpace tool. One thousand thirteen documents related to digital tourism, AI tourism, and tourism digitization in the Web of Science (WOS) database from 1991–2022 were collected. This study conducts bibliometric analysis to portray the knowledge map. Furthermore, this paper explores the publication years, co-occurrence of authors, institutions, subjects, research hotspots, and evolution of digital tourism research. The analysis findings revealed that social and environmental sciences are the core disciplines in digital tourism research. Hong Kong Polytechnic University is the foremost institution, and Tussyadiah and Wirtz are the authors with the highest contribution rate. Moreover, the results emphasized the frontier studies of digital tourism referring to technology, consumption, tourists’ reviews, and the progress of the tourism industry. In addition, China, Europe, and the United States should strengthen their digital tourism cooperation with Africa and the South America to promote the sustainable development of global tourism. Finally, the results implicate the future development trends of digital tourism.
AcknowledgmentWe acknowledge all the authors involved in the creation of this paper: Chen Luo for providing the opportunity for this research and collaborative creation, and Dr. Songyu Jiang, Dr. Ruihui Pu, and Dr. Lin Li for providing creative ideas and collaborative division for this paper, and for funding the research. Dr. Hongmei Yang further provides the research direction and future in the development process of digital tourism.
Mastocytosis: retrospective analysis of maculopapular cutaneous form
Authors: Kasikhina E. I. , Potekaev N. N. , Kochetkov M. A. , Zhukova O. V. , Ostretsova M. N. , Mednikova M. A. , Bogdel A. M.
Published: December 2022

Introduction. The article presents the data of a retrospective analysis of the debut and clinical manifestations of the types of maculopapular cutaneous mastocytosis (МPCM) in 96 children, and the frequency of non-regression of skin rashes with age in 33 adults. Aim. To conduct a retrospective analysis of the onset, clinical manifestations and dynamics of maculopapular cutaneous mastocytosis (MPCM). Materials and methods. Outpatient records of  96  children and 33  adults, who were treated and monitored at the  Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, were statistically analyzed. Results. Monomorphic type of MPCM was diagnosed in 28 (29.2%) patients, polymorphic – in 68 (70.8%) patients. In 92.6% of children with a polymorphic type and in 35.7% with a monomorphic type, the rash debuted at the age of two years. The clinical picture of the monomorphic type was dominated by multiple small brown or yellow-brown spots. Rashes in the polymorphic type were spread, represented by brown or reddish-brown spots, papules, plaques ranging in size from several millimeters to several centimeters. The positive phenomenon of Unna-Darier was determined in 82.3% of cases. In patients with polymorphic type, the general population level of tryptase (<11.4 µg/l) was determined significantly more often than in patients with monomorphic type (p < 0.05). Elevated tryptase level was found in 53.6% of children and 69.7% of adults with monomorphic rashes. Pruritus was the most common cutaneous symptom, occurring in 49.0% of children. Bullous eruptions developed only in patients with polymorphic type. The most frequently reported systemic manifestations were gastrointestinal symptoms and headaches. Conclusions. The obtained results suggest that patients with early onset of the disease with polymorphic and variable lesions show a more favorable outcome.
Screening testing and computerized vestibulometry in vestibular neuronitis
Authors: Lilenko S. V. , Sugarova S. B. , Lilenko A. S. , Kostevich I. V.
Published: December 2022

Introduction. The demonstrative example of  unilateral peripheral vestibulopathy is vestibular neuronitis. This disease of infectious-toxic origin has the involvement of vestibular ganglia neurons or vestibular nerve fibers. The overwhelming moment in topic diagnostics of vestibular impairments is within-patient comparison anamnesis data and vestibulometry results. In cases of vestibular neuronitis exception of central vestibular system pathology is mandatory. Objective. To attain objectification of disequilibrium in vestibular neuronitis by means of registration and assessment of oculogyric and postural reactions. Materials and methods. Vestibular passport trials are recommended in the examination of patients with acute vertiginous complaints. Special attention has been given to the revelation of impairments of command eye movements, disturbances of ocular pursuit, spontaneous nystagmus, and catch-up saccades in Halmagyi – Curthoys test. Possible impairments of static and dynamic balance control are assessed in modified Romberg test and Unterberger test. Gaze tests with registration of saccadic and pursuit eye movements, spontaneous and optokinetic nystagmus reactions as well bithermal caloric test are carried out in computerized electrooculography and videooculography. Deviations of body gravity center are analyzed with the help of sensory organization test in computerized dynamic posturography. Results and discussion. The results of screening and computerized vestibular testing of 24 patients are presented. High diagnostic value of registration and analysis of oculogyric reactions as well as postural control signs is demonstrated in cases of acute vestibular neuronitis and acerbation of its chronic recurrent variant. The key objective symptom, which confirms peripheral level of  vestibular dysfunction, is spontaneous nystagmus registration in  elimination of  gaze fixation. Unsteadiness in  static and dynamic trials confirms the vestibular decompensation extent in acute phase of vestibular ganglia / neurons pathology in cases of vestibular neuronitis. Decompensation signs revelation of this peripheral vestibular dysfunction needs urgent medicine: possible etiotropic and obligate symptomatic therapy as well as spare vestibular rehabilitation exercises. Conclusion. Combination of oculogyric impairments and disturbances of postural control enables to improve accuracy of diagnostics in decompensated stage of vestibular neuronitis.
Analysis of electromechanical coupling characteristics of electrics vehicle electric drive system considering current harmonic excitation
Authors: Ge Shuaishuai , Yang Yufan , Zhang Zhigang , Yang Yaoze , Shu Ruizhi
Published: December 2022

In order to study the electromechanical coupling dynamics characteristics of the drive motor and gear transmission system in the electric vehicle electric drive system, firstly, an electromechanical coupling dynamics model of the electric vehicle electric drive system is established; the electromechanical coupling vibration characteristics of the electric drive system under current harmonic excitation is compared and analyzed. The influence law of permanent magnet synchronous motor current harmonics on the meshing vibration of gear transmission system is revealed. The simulation results show that there is an obvious electromechanical coupling effect in the electric drive system; the harmonics of the drive motor can aggravate seriously the vibration state of the mechanical drive system; the research results provide a theoretical reference for further research on the vibration source positioning and active vibration reduction control strategy for the electric drive system of electric vehicles.
Model of a pipe robot with limited interactions
Authors: Ragulskis K. , Spruogis B. , Matuliauskas A. , Mištinas V. , Ragulskis L.
Published: December 2022

Nonlinear interactions between the exciting mass and the case of a pipe robot are important in order to prevent impacts of the exciting mass with the case of the pipe robot. Those impacts lead to deterioration of operation of a pipe robot and even may lead to destruction of some parts of the robot. Model for the analysis of dynamics of a pipe robot with limited interactions is proposed in this paper. For this purpose, a special expression of nonlinear stiffness is used. Results of investigations for various parameters of the system are presented.
Exploration of the effect of simultaneous removal of EDCs in the treatment process of different types of wastewater
Authors: Wu Lieshan , Lu Chunliu , Huang Ning , Zhong Minjie , Teng Yunmei , Tian Yan , Ye Kaixiao , Liang Liuling , Hu Zaoshi
Published: December 2022

The SPE-HPLC-MS/MS method was used to investigate the concentration distribution of nine types of estrogens in 18 locations of pollution source along the Jiuzhou River belonging to river systems in Guangdong province and Guangxi Zhuang autonomous region in China, and the estrogenic activity and potential ecological risks were evaluated by calculating the estradiol equivalency (EEQ). The results showed that the calculated estradiol equivalents (cEEQs) of wastewater treatment plants from 17 locations were all higher than 1 ng/L. To further study the removal effect of the treatment process on the estrogens, the pig breeding wastewater from P4 and the municipal wastewater from P13, as well as the black-odorous water, were sampled and surveyed during the entire process. It turned out that estrogens were effectively removed after nitrification activated sludge treatment. Meanwhile, there was a positive correlation between the removal of NH3-N, total nitrogen (TN) and total phosphorus (TP) and the removal of endocrine disrupting chemicals (EDCs). It is shown in the study the secondary treatment process has achieved a significant effect on the removal of estrogen in both the wet and dry periods and that there has been a positive correlation between the activities of total phosphorus compounds, nitrogen-based compounds and the removal of EDCs.
Animar o vazio
Authors: Torres Machado Vinicius , Ferreira dos Santos Ribeiro João Pedro
Published: December 2022

Este artigo tem por objetivo apresentar reflexões sobre o uso da máscara no espetáculo da tragédia grega antiga, de modo a contribuir para que pesquisadores e artistas contemporâneos da cena possam reconstituir imaginativamente alguns aspectos dessa teatralidade. Para tanto, serão apresentadas e analisadas fontes da cultura material, com base em estudos recentes sobre o tema.
The Status of Messianic Jews on mixed marriage in the canonicallegalorderanditscanonicalimplications
Authors: Wilk Jacek
Published: December 2022

W zaprezentowanym opracowaniu przedmiotem uwagi Autora stała się kwestia statusu Żydów Mesjanistycznych w przedmiocie małżeństw mieszanych w kanonicznym porządku prawnym. Badając doktrynę wspólnoty Żydów Mesjanistycznych Autor wyka- zał, iż charakteryzuje się ona synkretyzmem, zawierając zarówno elementy judaistyczne, jak i chrześcijańskie, wśród których istotną staje się wiara w Jezusa Chrystusa jako Mesja- sza. Patrząc na tą doktrynę przez pryzmat regulacji dotyczących małżeństw mieszanych w prawie kanonicznym (kan. 1086, 1125 KPK/83) dowiódł, iż o statusie drugiej strony nie decyduje wiara w Chrystusa, ale przyjęty chrzest; tego sakramentu nie przyjmuje się na- tomiast u Żydów Mesjanistycznych. Stąd też traktować ich należy jako nieochrzczonych. W efekcie podpadają oni pod przeszkodę różności religii (kan. 1086 KPK/83).

Oprócz tego Autor wskazał, iż pokaźna część członków tej wspólnoty jest nie-Żydami, o proweniencji chrześcijańskiej, dlatego też należy ich traktować jako ochrzczonych; podpadają więc oni pod przeszkodę odmiennego wyznania (kan. 1125 KPK/83).
Giuseppe Mazzanti, Matrimoni post- tridentini . Un debattito dottrinale fra continuitá e cambiamento (secc . XVI-XVIII), Bononia Univeristy Press, Bologna 2020, ss. 235.
Authors: Dzierżon Ginter
Published: December 2022

Publikacja jest recenzją monografii z zakresu prawa kanonicznego.
Exposición de la hermenéutica analógica
Authors:   Universidad Nacional Autónoma de México, Beuchot Mauricio
Published: December 2022

Con el objetivo de superar la crisis en la que se encuentra la filosofía hoy, se expone de manera sencilla una propuesta de una hermenéutica analógica. Se trata de una teoría de la interpretación que incorpora el concepto de la analogía, noción que evitará caer en la postura unívoca de los positivismos y en la equívoca de los posmodernismos. Esto permitirá salir a terrenos más promisorios y fructíferos para la labor filosófica. Para ello, en primer lugar, se desarrollará la concepción de hermenéutica en general y, en segundo lugar, se expondrá el concepto de analogía, de la que toma su nombre la hermenéutica analógica, a fin de que su concepto sea comprendido más fácil y claramente
La crítica de Simondon al antropocentrismo moderno
Authors:   Liceo Enrique Molina,Concepcion, Chile, Angulo Vera Pablo
Published: December 2022

El presente ensayo resume la crítica del filósofo Gilbert Simondon al antropocentrismo moderno y a las concepciones sobre la técnica desarrolladas en el siglo XX por ciertas corrientes filosóficas que provienen, según él, de lo que denomina un humanismo fácil, que circunscriben el desarrollo técnico a la racionalidad instrumental y a la distinción entre medios y fines. La propuesta de Simondon para salir del marco de estas visiones que considera reduccionistas, es ampliar nuestra mirada sobre la técnica, no centrarnos en la relación entre medios y fines y adentrarnos en el conocimiento sobre los modos de existencia de los objetos técnicos. La mirada de Simondon nos invita a repensar nuestra relación con la técnica y, más allá incluso, a revisar nuestras concepciones ontológicas inclinándose por las que hoy conocemos como ontologías relacionales. La técnica para el filósofo francés es un puente entre nuestro pasado ritual y nuestra actualidad que persiste en la co-existencia de todos los seres, vivos y no vivos que conforman el tecno ecosistema.
PAK1 Inhibition Suppresses the Proliferation, Migration and Invasion of
Glioma Cells
Authors: Shi Hengliang , Yi Qinghao , Chen Tianze , Zhou Kunlin , Ma Qiang , Sun Zhiyuan
Published: December 2022

Background:

p21-activated kinase 1 (PAK1) is abnormally expressed in glioma, but its
roles and mechanisms in glioma remain unclear. This study aims to explore the effects of PAK1 inhibition
on the proliferation, migration and invasion of glioma cells.

Method:

Cell Counting Kit-8 (CCK-8), 5‐ethynyl‐20‐deoxyuridine (EdU) incorporation and colony
formation assays were performed to evaluate the effects of PAK1 inhibition on the proliferation of
glioma cells. The cell cycle distribution and apoptosis rate of glioma cells were explored by flow cytometry.
Wound healing and Transwell assays were performed to investigate the effects of PAK1 inhibition
on glioma cell migration and invasion. The orthotopic xenograft glioma model was used to
probe the effect of PAK1 silencing on glioma tumor formation.

Results:

PAK1 inhibition arrested cells at the G1 phase and induced apoptosis of glioma cells. Moreover,
the knockdown of PAK1 decreased the protein expression levels of MDM2, p38, p-p38, cyclin
D1, CDK4, Bcl-2, MMP2, MMP9, and cofilin but increased the protein levels of p53, Bax, p21 and
cleaved caspase-3. A xenograft glioma model confirmed that the silencing of PAK1 repressed the
formation of tumors induced by U87 cell transplantation.

Conclusion:

This study showed that PAK1 inhibition impedes the proliferation, migration, and invasion
of glioma cells.
Clinical, Genetic, and Pathological Features of very Early Onset Frontotemporal
Lobe Degeneration: A Systematic Review
Authors: Chu Min , Wu Liyong , Liu Li , Nan Haitian , Jiang Deming , Wang Yihao , Rosa-Neto Pedro
Published: December 2022

Background:

In most patients with frontotemporal lobe degeneration (FTLD), the degenerative
process begins between the ages 45 and 65 years; onset younger than 45 years is relatively rare
and considered very early onset FTLD (VEO-FTLD).

Objective:

To delineate the clinical, genetic, and pathological features of VEO-FTLD.

Methods:

A systematic literature review was carried out in PubMed and Embase from inception to
September 2021. Patients diagnosed with definite FTLD with onset before age 45 years were included.
Patients lacking detailed clinical data or both genetic and neuropathological data were excluded.
Phenotypic, genotypic, and pathological data were extracted for further analyses.

Results:

Data from 110 patients with VEO-FTLD, reported in a cumulative 70 publications, were included.
Age of onset was 35.09 ± 7.04 (14-44) years. Sixty-seven patients were reported age at death
of 42.12 ± 7.26 (24–58) years, with a disease course lasting 8.13 ± 4.69 (1–20) years. Behavioural
variant frontotemporal dementia (104/110, 94.5%) was the most common clinical subtype, often manifesting
as disinhibition (81.8%) and apathy (80.9%), and frequently accompanied by a cognitive deficit
(90.9%) and parkinsonism (37.3%). Frequency of familial aggregation was high (familial vs. sporadic,
73/37, 66.4%); most patients carried MAPT gene mutations (72.9% in familial, 40% in sporadic),
followed by C9 (18.8% in familial, 10% in sporadic), TARDBP (2.1% in familial), and VCP
(2.1% in familial). The most common neuropathology subtype was tau (43.5%), followed by ubiquitin-
positive (24.6%), FUS (20.3%), and TDP 43 (2.9%).

Conclusions:

VEO-FTLD may have unique clinical, genetic, and neuropathological markers and
should be considered in young patients with psycho-behavioral symptoms.
Ethosomes: Novel Vesicular Carriers for Effective Transdermal Delivery of Natural Therapeutics
Authors: Bhatia Shiveena , Singh Varinder , Singh Manjinder , Singh Deepinder , Singh Tanveer , Piplani Mona , Singh Ravinder
Published: December 2022

The topical delivery, being the most reliable route for drug administration, offers multiple advantages.
The conventional topical dosage forms deliver a relatively higher amount of drug to achieve
therapeutic action triggering hypersensitivity reactions accompanied by greasiness and staining issues.
The advent of transdermal nanocarriers has waived off some of these limitations and assisted in achieving
enhanced therapeutic efficacy with sustained release and minimal/no instances of systemic toxicity. The
ethosome, one of the novel lipid carrier systems, has eased the administration of many hydrophilic and
lipophilic drugs through the stratum corneum. It is a non-invasive drug carrier consisting of 45% ethanol,
phospholipids, and non-ionic surfactants. The discovery of ethosomal technology has proved to be fruitful
in delivering drugs with a wide range of polarity and other physicochemical parameters across skin. In
this review, the ethosomal system has been explored for the delivery of complex phytoconstituents across
the skin along with the key building material of ethosomes, associated mechanism of drug delivery, recent
developments in ethosomes as a drug carrier, reported ethosomal formulations encapsulating various plant
metabolites, conducted clinical trials and available ethosomal formulations for the delivery of phytocomponents
across stratum corneum.
Phytochemistry and Pharmacological Profile of Drumstick Tree “Moringa
oleifera Lam”: An Overview
Authors: Singh Sonia , Dubey Sudhanshu , Rana Nishu
Published: December 2022

Background:

The herbal plant “Moringa oleifera Lam” is widely cultivated throughout
India. The plant belongs to the Moringaceae family. It is commonly called as Drumstick tree
and Horse-radish tree. Sometimes, the plant Moringa oleifera is called a “Miracle tree or Tree of
life.”

Objective:

The current manuscript summarizes the phytochemical constituents and pharmacological
properties of M.oleifera.

Methods:

Several pieces of literature have been searched in books, journals, and databases, including
ScienceDirect, Web of Science, Publons, and Scopus.

Results:

The fruits and leaves of M. oleifera are generally used as a vegetable in the Indian subcontinent
region. The whole parts of a plant contain valuable and essential therapeutic features; it
has the richest content of antiradical components and nutrients. Various secondary components
include hexacosone, pentacosane, phytol, carotenes, tocopherols, isothiocyanates, myricetin,
quercetin, kaempferol, rutin, chlorogenic acid, ferulic acid, sinalbin, and gallic acid. It contains a
higher percentage of vitamin A-E and vitamin K. Some mineral components include copper, calcium,
potassium, iron, magnesium, zinc, and manganese. It has approximately more than forty
naturally occurring antiradical constituents. The plant has diversified medicinal applications such
as antidiabetic, antiasthmatic, anti-inflammatory, anticancer, antifertility, antiallergic, antipyretic,
wound healing, analgesic, central nervous system activity, and hepatoprotective activities. The
plant Moringa oleifera Lam has been found effective in various infections and diseases.

Conclusion:

This article provides a detailed explanation of the phytochemical and pharmacological
activity of the plant that is being discussed.
Recent Advances on Natural and Non-Natural Xanthones as Potential
Anticancer Agents: A Review
Authors: Gogoi Urvashee , Pathak Kalyani , Saikia Riya , Pathak Manash Pratim , Paul Tirna , Khan Shah Alam , Das Aparoop
Published: December 2022

Background:

Xanthones, natural or synthetic, due to their wide range of biological activities,
have become an interesting subject of investigation for many researchers. Xanthonic scaffold
has proven to have a vital role in anticancer drug development since many of its derivatives have
shown anticancer activities on various cell lines. In addition, targeting epigenetic markers in cancer
has yielded promising results. There have also been reports on the impact of xanthone and related
polyphenolic compounds on epigenetics markers in cancer prevention and therapy.

Objective:

The objective of this review is to comprehensively highlight the main natural and nonnatural
sources of xanthones having potential anti-cancer effects along with their key structural elements,
structure-activity relationships (SARs), mechanisms of action, and epigenetic profile of xanthone-
based anti-cancer compounds. The challenges and future directions of xanthone-based therapies
are also discussed briefly.

Method:

The methods involved in the preparation of the present review included the collection of all
recent information up to November 2021 from various scientific databases, indexed periodicals, and
search engines such as Medline Scopus, Google Scholar, PubMed, PubMed Central, Web of Science,
and Science Direct.

Results:

Exploration of the diversity of the xanthone scaffold led to the identification of several derivatives
having prominent anti-cancer activity. Their unique structural diversity and synthetic modifications
showed the ongoing endeavour of enriching the chemical diversity of the xanthone molecular
framework to discover pharmacologically interesting compounds. However, studies regarding
their modes of action, pharmacokinetic properties, clinical data, epigenetics, and safety are limited.

Conclusion:

Elucidation of the exact biological mechanisms and the associated targets of xanthones
will yield better opportunities for these compounds to be developed as potential anticancer drugs.
Further clinical studies with conclusive results are required to implement xanthones as treatment
modalities in cancer.
Anticancer Activity of 3,5-Bis(dodecyloxy)Benzoate-PAMAM Conjugates
with Indomethacin or Mefenamic Acid
Authors: Castillo-Rodríguez Irving Osiel , Pedro-Hernandez Luis Daniel , Ramírez-Ápan Teresa , Martínez-García Marcos
Published: December 2022

aims:

The aim of the present investigation was the synthesis of 3,5-bis(dodecyloxy)benzoate -PAMAM conjugates with indomethacin an mefenamic acid to examine their anticancer activity.

background:

The synthesis of conjugates with nonsteroidal anti-inflammatory drugs could be improve their activity with less toxicity and these compounds could be used for the treatment of cancer.

objective:

The synthesis of 3,5-bis(dodecyloxy)benzoate -PAMAM conjugates with indomethacin or mefenamic acid to examine their anticancer activity.

method:

The anticancer activity was studied of the conjugates against six human cancer cells U-251 (human glioblastoma), PC-3 (human prostatic adenocarcinoma), K-562 (human chronic myelogenous leukemia cells), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma), SKLU-1 (human lung adenocarcinoma) and the COS-7 African green monkey (as a control) cell lines. The conjugates with indomethacin and mefenamic acid were characterized by 1H, 13C NMR one- and two-dimension spectroscopy.

result:

All the conjugates synthetized with indomethacin or mefenamic acid showed anticancer activity against all the human cancer cell lines. The first generation of indomethacin conjugates showed better activity against PC-3 cell line than the second generation. But the second generation with indomethacin showed better activity against PC-3 (human prostatic adenocarcinoma) than the first generation. The second generation conjugate with mefenamic acid had strong selectivity to PC-3 (human prostatic adenocarcinoma) cells with IC50 value of 10.23±1.2 M in vitro.

conclusion:

In the paper, we report the synthesis and spectroscopic analyses of new indomethacin or mefenamic acid conjugates. The overall results showed that the conjugate of second generation with mefenamic acid could be a potential nanocarrier for human prostatic adenocarcinoma cancer treatment.

other:

our research will be continued
Overview of High-Performance Thin Layer Chromatography and its
Applications in Pesticide Analysis
Authors: Kandasamy Ruckmani , Muruganantham Selvakumar , Krishnaswami Venkateshwaran , Alagarsamy Shanmugarathinam
Published: December 2022

In recent decades, increased demand for food has been caused by a rapid rise in the human
population, which triggers agricultural intensification. To resist undesired pests from infecting crops,
farmers widely utilize pesticides to improve agricultural production during the pre-harvest period. Despite
the fact that pesticides cause a number of health risks, there is insufficient monitoring of these toxins.
Therefore, it is important to develop a specific, accurate, and efficient method for determining the pesticides
in varied samples in order to safeguard health against potential risks. Due to the lower concentrations
of active compounds and their diversity of availability, it is challenging to detect pesticide residues
in different samples. In this case, to effectively separate, identify, and accurately quantify pesticides at
low concentrations in a variety of samples, a reliable analytical methodology is needed. Recently, the
application of high-performance thin layer chromatography (HPTLC) offers a wider scope with excellent
separation, identification, and quantitative/qualitative determination in pesticide analysis. In spite of their
extremely low quantities, pesticide residues can be accurately and precisely identified using HPTLC.
HPTLC has a number of benefits, such as easy sample preparation, automation, densitometry, and hyphenation,
and is particularly well suited for identification and detection. Concerning this, the proposed
review paper provides an overview of stationary phases, mobile phases, sample applicators, visualization,
derivatization, and detection of HPTLC utilized for the identification and detection of pesticide residues
in agriculture and environmental samples.
Imbalance of Th1 and Th2 Cytokines and Stem Cell Therapy in
Pathological Pain
Authors: Yu Yao-Qing , Wang Huan
Published: December 2022

The pathophysiological importance of T helper 1 (Th1) and Th2 cell cytokines in pathological
pain has been highly debated in recent decades. However, the analgesic strategy targeting individual
cytokines still has a long way to go for clinical application. In this review, we focus on the contributions
of Th1 cytokines (TNF-α, IFN-γ, and IL-2) and Th2 cytokines (IL-4, IL-5, IL-10, and IL-13)
in rodent pain models and human pain-related diseases. A large number of studies have shown that
Th1 and Th2 cytokines have opposing effects on pain modulation. The imbalance of Th1 and Th2 cytokines
might determine the final effect of pain generation or inhibition. However, increasing evidence
indicates that targeting the individual cytokine is not sufficient for the treatment of pathological pain.
It is practical to suggest a promising therapeutic strategy against the combined effects of Th1 and Th2
cytokines. We summarize the current advances in stem cell therapy for pain-related diseases. Preclinical
and clinical studies show that stem cells inhibit proinflammatory cytokines and release enormous
Th2 cytokines that exhibit a strong analgesic effect. Therefore, a shift of the imbalance of Th1 and Th2
cytokines induced by stem cells will provide a novel therapeutic strategy against intractable pain. It is
extremely important to reveal the cellular and molecular mechanisms of stem cell-mediated analgesia.
The efficiency and safety of stem cell therapy should be carefully evaluated in animal models and patients
with pathological pain.
Fracture Resistance and Failure Mode of Endocrown Restorations with Different Remaining Walls and Finish Lines
Authors: Koosha Sara , Mostafavi Azam S. , Jebelizadeh Mahdieh S. , Ghasemi Mahsa , Hayerimaybodi Mahrad
Published: December 2022

Objective:

Endocrown is a conservative treatment plan for endodontically treated teeth. The aim of this study was to evaluate the fracture resistance of four different preparation designs of endocrown restorations in mandibular molars.

Methods:

Thirty-six endodontically treated molars were divided into two groups (L, MD). In group L, the lingual wall and in group MD, mesial and distal walls were removed up to 1 mm above the CEJ. For each group, 2 subgroups (n=9) were considered: B) 2mm occlusal reduction with but joint finish line, S) axial reduction with radial shoulder finish line, in addition to 2mm occlusal reduction. Digital impression was performed, followed by designing and milling the lithium disilicate blocks. After cementation of the restorations and thermocycling, fracture resistance and failure mode were investigated.

Results:

Groups LB and LS, showed significantly higher fracture resistance compared to groups MDB and MDS (P=0.02). However, the type of finish line did not have a significant effect on the fracture resistance in the experimented groups (P=0.232).

Conclusion:

Unlike the finish line type, the number of remaining axial walls had a significant effect on fracture resistance. Although most of the fractures were catastrophic, they occurred due to forces much greater than usual.
Electronic Apex Locators and their Implications in Contemporary Clinical Practice: A Review
Authors: Shirazi Zainab , Al-Jadaa Anas , Saleh Abdul Rahman
Published: December 2022

Background:

The apical extent of instrument termination and final root-filling procedures have been found to be key prognostic factors in relation to the outcome of root canal treatment. The precise location of this termination point has always been a challenge in clinical endodontics. Until the introduction of contemporary electronic apex locators (EALs), conventional radiography was traditionally used to determine the working length. Since their inception more than 50 years ago, EALs have drawn a great deal of attention.

Objective:

The literature pertaining to these devices is saturated yet inexhaustive and controversial. While most reviews try to summarize this topic entirely, the scope of the subject makes this close to impossible. Most systematic reviews report a lack of high-quality evidence, making it impossible to reach a meaningful conclusion. This review of literature focuses on electronic apex location and its accuracy, specifically in relation to variables in the clinical setting that a practitioner might encounter while using this device.

Methods:

Electronic database searches were undertaken using a combination of key search words to find relevant studies about EALs.

Results:

The PubMed (MEDLINE) search engine was used to find studies published in the English language with no restrictions for time. Articles that were found to be most pertinent were chosen and included in the review.

Conclusion:

EALs are indispensable to the practice of endodontics; however, the adjunct use of radiographs remains a reasonable practice.
Current Status of Pharmacokinetic Research in Children: A Systematic
Review of Clinical Trial Records
Authors: Thangaraju Pugazhenthan , Velmurugan Hemasri , Neelambaran Krishnapriya
Published: December 2022

Background:

Many medications have different pharmacokinetics in children than in adults.
Knowledge about the safety and efficacy of medications in children requires research into the pharmacokinetic
profiles of children's medicines. By analysing registered clinical trial records, this study determined
how frequently pharmacokinetic data is gathered in paediatric drug trials.

Methods:

We searched for the pharmacokinetic data from clinical trial records for preterm infants and
children up to the age of 16 from January 2011 to April 2022. The records of trials involving one or
more drugs in preterm infants and children up to the age of 16 were examined for evidence that pharmacokinetic
data would be collected.

Results:

In a total of 1483 records of interventional clinical trials, 136 (9.17%) pharmacokinetic data
involved adults. Of those 136 records, 60 (44.1%) records were pharmacokinetics trials involving one
or more medicines in children up to the age of 16.20 (33.3%) in America, followed by 19 (31.6%) in
Europe. Most trials researched medicines in the field of infection or parasitic diseases 20 (33.3%). 27
(48.2%) and 26 (46.4%) trials investigated medicines that were indicated as essential medicine.

Conclusion:

The pharmacokinetic characteristics of children's drugs need to be better understood. The
current state of pharmacokinetic research appears to address the knowledge gap in this area adequately.
Despite slow progress, paediatric clinical trials have experienced a renaissance as the significance
of paediatric trials has gained international attention. The outcome of paediatric trials will have an impact
on children's health in the future. In recent years, the need for greater availability and access to
safe child-size pharmaceuticals has received a lot of attention.
COMMUNITY GROUP CARING FOR HEALTHY LUNGS (MADUPASEH) TOWARDS THE PREVENTION OF PULMONARY TUBERCULOSIS IN YOKA VILLAGE
Authors:   Nurse Profession Study Programme, Health Polytechnic of Ministry of Health Jayapura, Rohmani Rohmani , Apay Frengky ,   Nursing Diploma Study Program, Health Polytechnic of Ministry of Health Jayapura, Kusuma Ardhanari Hendra ,   Applied Nursing Undergraduate Study Program, Health Polytechnic of Ministry of Health Jayapura, Rumaseb Ester ,   Nursing Diploma Study Program, Health Polytechnic of Ministry of Health Jayapura
Published: December 2022

Tuberculosis (TB) is an infectious disease caused by infection with the bacterium Mycobacterium tuberculosis. The source of transmission is tuberculosis patients with positive Acid Resistant Bacillus (positive BTA) through splashes of sputum droplets that they emit. Indonesia is the country with the second highest number of new cases in the world after India. The purpose of this community service is to empower the people of Yoka Village in the Prevention of Pulmonary TB by forming a Healthy Lung Care Community (MADUPASEH). The method in this implementation is to conduct a Focus Group Discussion (FGD) with the Yoka Village Government and the Head of the Yoka Health Center to discuss the problems in Yoka Village. The result: this community service was attended by the Head of Yoka Village along with village government staff, the community, ondoafi leaders, ondofolo, youth leaders, women leaders, and TB Paru cadres in Yoka Village.
Studi Kelayakan Pengadaan Tanah guna Penanggulangan Banjir pada Sungai Kali Lamong Kabupaten Gresik
Authors: Setiyowati Yunita Ayu , Sholichin Moh , Prayogo Tri Budi
Published: December 2022

Banjir merupakan masalah yang rutin dialami oleh masyarakat di wilayah Sungai Kali Lamong, khususnya di Desa Jono dan Desa Tambakberas, Kecamatan Cerme, Kabupaten Gresik. Oleh sebab itu untuk mengurangi masalah banjir, diperlukan pembangunan tanggul. Akan tetapi, pembangunan tanggul memerlukan adanya pengadaan tanah pada lokasi yang direncanakan. Tujuan dari studi ini adalah melakukan analisa banjir dengan program HEC-RAS, melakukan studi kelayakan terhadap pembangunan tanggul yang meliputi kelayakan ekonomi, analisa dampak lingkungan, dan memperkirakan pengadaan tanah yang diperlukan untuk pembangunan tanggul. Dari analisa hidrologi dengan menggunakan Hidrograf Satuan Sintesis (HSS) Nakayasu, debit yang digunakan dalam perencanaan tanggul adalah Q10 = 346.81 m3/dt. Lalu dilakukan running dengan HEC-RAS dan didapatkan dimensi tanggul parapet beton yang mampu mengatasi banjir dengan dimensi H = 3,5m. Pembangunan tanggul memerlukan nilai biaya (cost) sebesar Rp. 23.090.600.000,- dan manfaat (benefit) yang didapat dari pembangunan tanggul sebesar Rp. 23.954.706.640, sehingga nilai BCR 1.04, NPV 0.78, dan IRR 17%. Sehingga secara ekonomi, pembangunan tanggul layak untuk dilakukan. Berdasarkan hasil penapisan, pembangunan tanggul ini tidak memerlukan AMDAL secara lengkap, namun hanya perlu UKL dan UPL yang berisi dampak, besaran dampak, tujuan pengelolaan, upaya pengelolaan lingkungan hidup, dan lokasi pengelolaan.
Kajian Perencanaan Sistem Pelimpah Bendungan Semantok Kabupaten Nganjuk Provinsi Jawa Timur
Authors: Prasetyo Wibi Bagus , Priyantoro Dwi , Sisinggih Dian
Published: December 2022

Bendungan Semantok dibangun dengan ambang berbentuk setengah lingkaran untuk mengalirkan air melalui pelimpah agar tidak terjadi overtopping. Maka dalam studi ini membahas kajian sistem pelimpah untuk mengetahui efisiensi dari bentuk ambang serta dimensi yang direncanakan. Bentuk ambang yang direncanakan adalah hasil modifikasi dari overflow dan side channel spillway. Dalam perencanaanya perlu dilakukan routing untuk mengetahui debit yang melintasi serta perancangan dimensi yang sesuai kondisi eksisting. Untuk mengalirkan air kembali pada sungai di perlukan pembuatan saluran pengarah akhir (escape channel) dengan panjang 1,07 Km. Perencanaan dimensi dan hidrolis saluran perlu juga dilakukan perhitungan kavitasi guna mengetahui ke amanan sebuah saluran untuk mencegah terjadinya penggerusan.
Kajian Perencanaan Sistem Pelimpah Bendungan Semantok Kabupaten Nganjuk Provinsi Jawa Timur
Authors: Prasetyo Wibi Bagus , Priyantoro Dwi , Sisinggih Dian
Published: December 2022

Bendungan Semantok dibangun dengan ambang berbentuk setengah lingkaran untuk mengalirkan air melalui pelimpah agar tidak terjadi overtopping. Maka dalam studi ini membahas kajian sistem pelimpah untuk mengetahui efisiensi dari bentuk ambang serta dimensi yang direncanakan. Bentuk ambang yang direncanakan adalah hasil modifikasi dari overflow dan side channel spillway. Dalam perencanaanya perlu dilakukan routing untuk mengetahui debit yang melintasi serta perancangan dimensi yang sesuai kondisi eksisting. Untuk mengalirkan air kembali pada sungai di perlukan pembuatan saluran pengarah akhir (escape channel) dengan panjang 1,07 Km. Perencanaan dimensi dan hidrolis saluran perlu juga dilakukan perhitungan kavitasi gunaÂ  mengetahui ke amanan sebuah saluran untuk mencegah terjadinya penggerusan.
Studi Pengaruh Kemiringan Lereng Terhadap Laju Infiltrasi
Authors: Qur'ani Nila Putri Gading , Harisuseno Donny , Fidari Jadfan Sidqi
Published: December 2022

Sub DAS Lesti merupakan salah satu sub das di Kabupaten Malang yang mengalami proses Infiltrasi. Dalam prosesnya, infiltrasi dipengaruhi oleh banyak faktor, salah satunya adalah faktor kemiringan lereng. Hal ini dikarenakan lahan dengan kemiringan lereng yang berbeda akan menghasilkan nilai laju infiltrasi yang berbeda pula. Maka dari itu penelitian ini bertujuan untuk mengetahui sebarapa besar pengaruh kemiringan lereng terhadap laju infiltrasi Di Sub DAS Lesti. Dalam pelaksanaannya, penelitian ini menggunakan alat Double Ring Infiltrometer untuk menghasilkan data berupa nilai laju infiltrasi dan waktu uji. Data dihitung menggunakanÂ  metode Horton untuk mendapatkan nilai laju infiltrasi kumulatif yang digunakan untuk pembuatan peta persebaran laju infiltrasi sesuai ketentuan US. Soil Conservation. Dari peta tersebut, di dapatkan klasifikasi laju infiltrasi yang akan dibandingkan dengan ketentuan dari Dulbahri. Hasil yang diperoleh dalam penelitian ini adalah berdasarkan ketentuan US. Soil Conservation, pada kemiringan 0-8% menghasilkan nilai 1.208,474 (Sangat cepat) lebih besar dibanding dengan kemiringan 8%-23% yang memiliki nilai 213,789 (Cepat). Selain itu, Dulbahri menetapkan bahwa kemiringan 0-8% memiliki tingkat infiltrasi tinggi, sedangkan di kemiringan 8%-23% memiliki tingkat infiltrasi sedang. Maka dari itu dapat disimpulkan bahwa kemiringan lereng Di Sub DAS Lesti sangat berpengaruh pada nilai laju infiltrasi yang di dapatkan.
Prediksi Laju Infiltrasi Berdasarkan Porositas Tanah dan Komposisi Tanah
Authors: Sonora Windy Ellprimus , Harisuseno Donny , Fidari Jadfan Sidqi
Published: December 2022

Penentuan laju infiltrasi di lapangan membutuhkan banyak waktu, biaya dan tenaga, sehingga diperlukan estimasi model empiris laju infiltrasi agar dalam penentuannya menjadi lebih mudah dan efisien. Namun penetapan parameter model empris laju infiltrasi masih sulit ditemukan karena ada banyak faktor yang mempengaruhi laju infiltrasi dan salah satu yang paling berpengaruh adalah sifat fisik tanah diantaranya porositas tanah dan tekstur tanah. Studi ini bertujuan untuk memprediksi model laju infiltrasi berdasarkan porositas tanah dan komposisi tanah di DAS Lesti yang penelitiannya masih terbatas. Dalam studi ini, pengukuran laju infiltrasi dilaksanakan pada 12 titik lokasi studi menggunakan Double Ring Infiltrometer dan analisa sampel tanah dilakukan di Laboratorium. Model prediksi laju infiltrasi dilakukan menggunakan analisa regresi linier berganda pada tiga alternatif variabel yang diajukan. Prediksi laju infiltrasi menghasilkan model persamaan regresi IRp=1.893+0.032(Porosity) -0.049(Silt) yang berasal dari alternatif variabel terbaik yaitu berdasarkan porositas tanah dan komposisi lanau dengan perbandingan antara nilai laju infiltrasi prediksi dan pengukuran di lapangan sebesar R2= 0,989, NSE= 0,724, RMSE= 0,495, dan bland altman plot (bias)= 0,209 yang menunjukkan bahwa akurasi model prediksi laju infiltrasi berdasarkan porositas tanah dan komposisi tanah lanau dapat dikatakan cukup sesuai.
Studi Perencanaan Saluran Sudetan Pada Kali Lamong Untuk Menanggulangi Banjir di Kabupaten Gresik, Provinsi Jawa Timur
Authors: Wardono Brigita Krisanti , Sholichin Moh , Sumiadi Sumiadi
Published: December 2022

Kondisi DAS Kali Lamong cukup memprihatinkan, sebab debit sungai Kali Lamong cenderung besar saat musim penghujan. Dari permasalahan penyebab terjadinya banjir Kali Lamong, maka perlu diadakan penanggulangan teknis berupa pembangunan sudetan, tanggul dan normalisasi sungai. Diharapkan dengan adanya penanggulangan banjir secara teknis dapat memperbaiki kondisi eksisting Kali Lamong. Dalam pelaksanaan teknis penanggulangan banjir, metode yang digunakan dalam penelitian yaitu analisis hidrologi DAS Kali Lamong, analisis hidrolika kondisi eksisting Kali Lamong menggunakan HEC-RAS 5.0.7, analisis hidrolika setelah adanya pembangunan sudetan, tanggul dan normalisasi menggunakan HEC-RAS 5.0.7 serta analisis biaya pembangunan penanggulangan teknis. Setelah dilaksanakannya pembangunan sudetan, tanggul dan normalisasi sungai pada Kali Lamong didapatkan hasil kapasitas tampungan sungai hingga kala ulang 25 tahun dengan kemampuan mereduksi tinggi muka air pada kondisi eksisting 6.877 m menjadi 6.645 m. Adapun keseluruhan biaya yang dibutuhkan dalam penanggulangan banjir ini sebesar Rp. 15.048.091.000,00 (lima belas miliyar empat puluh delapan juta sembilan puluh satu ribu rupiah).
Penentuan Skala Prioritas Rehabilitasi Jaringan Irigasi pada Daerah Irigasi Duk dan Daerah Irigasi Rejali di Kabupaten Lumajang dengan Metode Analytic Hierarchy Process (AHP) dan Metode Analytic Network Process (ANP)
Authors: Aufa Muhammad Shidqy , Wahyuni Sri , Prayogo Tri Budi
Published: December 2022

Kegiatan Operasi dan Pemeliharaan irigasi khususnya pada penilaian kondisi fisik jaringan irigasi sangat penting dalam menunjang ketahanan pangan nasional. Hal itu sesuai dengan tuntutan UU No. 11/1974 tentang Pengairan yang ditindaklanjuti bersamaan dengan Peraturan Pemerintah No.23/1982 tentang Irigasi, dan Permen PUPR NO.12/2015 terkait Pedoman Operasi dan Pemeliharaan irigasi. Daerah Irigasi Duk dan Daerah Irigasi Rejali yang terletak di Kabupaten Lumajang termasuk ke dalam daftar D.I. yang akan direhabilitasi oleh pemerintah. Tujuan dari penelitian ini yaitu untuk mengetahui skala prioritas dalam melakukan rehabilitasi aset irigasi dan estimasi biaya rehabilitasi. Dalam mendapatkan urutan skala prioritas rehabilitasi, digunakan metode Analytic Hierarchy Process (AHP) dan metode Analytic Network Process (ANP). Hasil penelitian menunjukkan bahwa prioritas rehabilitasi berdasarkan perhitungan kedua metode yaitu pada Bangunan Utama D.I. Rejali, sedangkan prioritas selanjutnya berdasarkan data dan survey lapangan yaitu pada Saluran Pembawa D.I. Duk. Adapun estimasi biaya rehabilitasi pada Bangunan Utama D.I. Rejali sebesar Rp 193.300.000,00 dan estimasi biaya rehabilitasi pada Saluran Pembawa D.I. Duk sebesar Rp 394.300.000,00.