bluuebunny/crossref_metadata_2025 huggingface dataset:
ЭКСПЕРИМЕНТАЛЬНАЯ УСТАНОВКА ДЛЯ ТЕСТИРОВАНИЯ ПЕРСПЕКТИВНОГО КОСМИЧЕСКОГО ГАММА-СПЕКТРОМЕТРА С МЕЧЕННЫМИ ЗАРЯЖЕННЫМИ ЧАСТИЦАМИ ДЛЯ ИЗУЧЕНИЯ ЭЛЕМЕНТНОГО СОСТАВА ВЕЩЕСТВА ЛУНЫ, МАРСА И ДРУГИХ НЕБЕСНЫХ ТЕЛ БЕЗ АТМОСФЕРЫ ИЛИ С ТОНКОЙ АТМОСФЕРОЙ
Authors:   ИКИ РАН, Аникин Артем , Митрофанов Игорь ,   ИКИ РАН, Литвак Максим , Санин Антон , Мокроусов Максим , Никифоров Сергей
Published: January 2023

Один из методов, которые используется для изучения распространённости химических элементов в грунте Луны или другого небесного тела без атмосферы или с тонкой атмосферой, - спектрометрия естественного гамма-излучения поверхности небесного тела, возникающего под действием бомбардировки грунта энергичными частицами галактических космических лучей (ГКЛ) (Митрофанов и др., 2019, 2020). Данный метод с успехом применяется для глобального картирования концентрации породообразующих элементов с борта орбитальных космических аппаратов (КА) и также может быть применён для изучения состава грунта в месте посадки стационарного КА или вдоль трассы движения мобильного посадочного КА. Как развитие этого метода был предложен перспективный прибор «космический гамма-спектрометр с меченными заряженными частицами» (КГС-МЗЧ), который использует метки времени от регистрации частиц ГКЛ протонным телескопом, входящим в его состав, для существенного снижения вклада в измеряемый сигнал фоновых гамма-квантов, возникших под воздействием ГКЛ в веществе самого КА или удалённых от прибора участков поверхности (Аникин и др., 2021). Для наземной отработки и калибровки КГС-МЗЧ была создана экспериментальная установка (ЭУ), которая позволяет имитировать движение мобильной исследовательской станции (ровера) по поверхности небесного тела. Для имитации потока ГКЛ использовался медицинский пучок протонов с энергией 160 МэВ, сформированный на ускорителе в Лаборатории ядерных проблем им. В. П. Джелепова Объединённого института ядерных исследований, г. Дубна. Протоны пучка попадают на мишень, производят в ней каскад вторичных частиц в основном - нейтронов и гамма-квантов. Гамма-кванты, образовавшиеся в реакциях неупругого рассеяния или захвата нейтронов ядрами, а также в результате распада образовавшихся радиоактивных изотопов, имеют строго определённые значения энергии, характерные для конкретных ядер. Таким образом, измерив интенсивность характеристических гамма-линий можно определить концентрацию химических элементов в составе мишени. В связи с тем, что канал протонного ускорителя стационарен, требовалось организовать безопасное перемещение тяжёлой мишени в направлении, перпендикулярном оси пучка протонов. В настоящей статье приводится описание созданной экспериментальной установки, мишени, её элементный состав и способы изготовления мишеней-вставок.
МОДЕЛИРОВАНИЕ МИГРАЦИИ ПРИМЕСИ В ПОЛИМЕРНОМ КОМПОЗИТЕ ПРИ ВАКУУМНОТЕПЛОВОМ ВОЗДЕЙСТВИИ
Authors:   МГТУ им. Н. Э. Баумана, Мелешко В.
Published: January 2023

Исследовано влияние факторов космического пространства на полиметилметакрилат с радиационным выходом 1,5 молекул/100 эВ, энергия электронов и протонов составляла 15 и 30 кэВ соответственно, а плотность потоков - 108 и 107 см2/с. Было установлено, что электронное облучение оказывает максимальное воздействие на профиль пространственно-временного распределения концентрации летучих веществ в материале, по сравнению с протонным облучением. При значениях коэффициента диффузии менее 0,001 мкм2/с облучение протонами и/или электромагнитным излучением приводит к быстрому накоплению летучих веществ в приповерхностном слое материала.
ИССЛЕДОВАНИЕ ПРОЦЕССА ЭЛЕКТРОННО-ЛУЧЕВОЙ СВАРКИ С ИСПОЛЬЗОВАНИЕМ МАТЕМАТИЧЕСКОГО МОДЕЛИРОВАНИЯ
Authors:   АО «НПЦ «Полюс», Осипенко А. , Костарев Игорь
Published: January 2023

Приводится описание исследования и моделирования процесса электронно-лучевой сварки по разработанной методике в математическом пакете, которая позволяет спрогнозировать распределение температуры в составных частях ЭМИО и подобрать наиболее оптимальный режим исходя из скорости движения пучка, его мощности, температуры и глубины проплавления кожуха и корпуса, исключающих деформацию элементов конструкции.
A Community-Engaged Social Marketing Campaign to Promote Equitable Access to COVID-19 Services Among Latino Immigrants
Authors: Shah Harita S. , Miller Alejandra Flores , Yang Cui , Grieb Suzanne M. , Lipke Mitchell , Bigelow Benjamin F. , Phillips Katherine H. , Palomino Pedro , Page Kathleen R.
Published: January 2023

To address disparities in COVID-19 outcomes among Latinos with limited English proficiency in Maryland, our team developed a culturally congruent intervention that coupled a statewide social marketing campaign with community-based COVID-19 services. In the first year, we reached 305 122 people through social media advertisements and had 9607 visitors to the Web site. Social marketing campaigns represent an opportunity to promote COVID-19 testing and vaccine uptake among Latino populations, especially when they are paired with community services that simultaneously address structural barriers to care. (Am J Public Health. 2023;113(3):263–266. https://doi.org/10.2105/10.2105/AJPH.2022.307191 )
PET-CT in the Evaluation of Neoadjuvant/Adjuvant Treatment Response of Soft-tissue Sarcomas
Authors: Castillo-Flores Samy , Gonzalez Marcos R. , Bryce-Alberti Mayte , de Souza Felipe , Subhawong Ty K. , Kuker Russ , Pretell-Mazzini Juan
Published: January 2023

➢ In soft-tissue sarcomas (STSs), the use of positron emission tomography-computed tomography (PET-CT) through a standardized uptake value reduction rate correlates well with histopathological response to neoadjuvant treatment and survival.

➢ PET-CT has shown a better sensitivity to diagnose systemic involvement compared with magnetic resonance imaging and CT; therefore, it has an important role in detecting recurrent systemic disease. However, delaying the use of PET-CT scan, to differentiate tumor recurrence from benign fluorodeoxyglucose uptake changes after surgical treatment and radiotherapy, is essential.

➢ PET-CT limitations such as difficult differentiation between benign inflammatory and malignant processes, inefficient discrimination between benign soft-tissue tumors and STSs, and low sensitivity when evaluating small pulmonary metastases must be of special consideration.
Event-Related Alpha Oscillatory Response in Early Stage of Facial Expression Processing in Social Anxiety: Influence of Language Context
Authors: Song Sutao , Liu Aixin , Shang Haiqing , Gao Shihao , Gao Zeyuan , Zhang Mingxian , Zhao Shimeng , Zheng Yuanjie , Ge’s Ruiyang
Published: January 2023

Background: Accurate interpretation of the emotional information conveyed by others’ facial expression is crucial for social interactions. The alpha oscillation response, which is an important event-related potential-based metric in studies of emotional information processing, to emotional facial processing in social anxiety is unclear.Method: In this case-control study, participants viewed facial expressions (angry, happy, neutral) preceded by a contextual sentence conveying either positive or negative evaluations about the participant. Contextual influences were reflected in rating and occipital and frontal alpha oscillation measured by event-related potentials (ERP).Results: With congruently emotional context and expression, occipital alpha oscillation power was significantly lower in social anxiety group than that in healthy control group. And in negative context, frontal alpha lateralization was significantly lower in social anxiety group than that in healthy control group.Conclusion: Social anxiety individuals showed stronger attentional inhibition of face expression processing only when the language context was emotionally congruent with the facial expression. The effect of context on facial expression processing in social anxiety individuals was manifested in the early stage of face processing as a contextual consistency effect, and the effect of negative information may be more pronounced.
Brain structural and functional changes in asymptomatic chronic internal carotid artery occlusion: protocol for a multi-modal MRI trial
Authors: Zhang Chi , He Yan-Li , He Chao , Li Yu-ting , Chen Zhu-Hong , Sun Jing-Ting , Shang Yu-Xuan , Hu Bo , Yu Ying , Zhao Yuan-Fang , Fan Yun-Yun , Cui Guang-bin , Wang Wen , Deng Jian-Ping , Sun Li-Li
Published: January 2023

Background: Whether asymptomatic chronicinternal carotid artery occlusion (CICAO) can cause cognitive impairment as well as its underlying neuroimaging alterations remain controversial. Multi-modal magnetic resonance imaging (MRI) has been extensively utilized in the study of cognitive impairment to reveal the potential brain functional or structural changes. We aim to investigate the underlying brain changes in asymptomatic CICAO patients with or without cognitive impairment by using multimodal MRI techniques.
Methods: First, patients with asymptomatic CICAO will be recruited from Tangdu hospital, and individuals without CICAO will be recruited as health controls (HC) from the local community. Then, these subjects will undergo a series of neuropsychology tests focusing on the cognition and multi-modal MRI brain scans. Appropriate statistical software will be utilized to investigate the neuropsychological performance and multimodal MRI data to investigate the potential associations between cognition and the neuroimaging features in patients with asymptomatic CICAO.
Discussion: In this study, multi-modal MRI will be used to evaluate the characteristics of asymptomatic CICAO. Imaging features that will be assessed include volumetric characteristics, functional characteristics and perfusion properties. Clinical information, such as basic information, age, gender, body mass index and educational level for asymptomatic CICAO will be collected for statistical analysis. Montreal Cognitive Assessment, Pittsburgh Sleep Quality Index, Self-rating Depression Scale and Self-rating Anxiety Scale will be applied to access cognition, sleep disorder, depression and anxiety, respectively. This clinical trial will help establish an effective screening system to assess cognitive impairment and the underlying neuroimaging biomarkers for asymptomatic CICAO disease.
Trial registration: This study has already been registered at Clinical Trials. Gov (ID: NCT04443439) on May 27, 2020.
Big data on the prevalence of injury deaths among 187 000 elderly Chinese in the past 20 years (2000-2020): a systematic review and meta-analysis
Authors: Yang Shanlan , Zhang Langlang , Zhu Xiang , Tu Jiaxin , Huang Helang , Yu Chao , Wu Lei
Published: January 2023

Background
This study systematically reviewed injury death and causes in the elderly population in China from 2000 to 2020, to prevent or reduce the occurrence of injuries and death.
Methods
The CNKI, VIP, Wan Fang, MEDLINE, Embase, SinoMed, and Web of Science databases were searched to collect epidemiological characteristics of injury death among elderly over 60 years old in China from January 2000 to December 2020. Random effects meta-analysis was performed to pool injury mortality rate and identify publication bias, with study quality assessed using the AHRQ risk of bias tool.
Results
(1) A total of 21 studies with 187 488 subjects were included, covering 125 million elderly. The pooled injury mortality rate was 135.58/105 (95% CI 113.36/105 to 162.14/105), ranking second in the total death cause of the elderly. (2)Subgroup analysis showed that male injury death (146.00/105) was significantly higher than that of females (127.90/105), and overall injury mortality increased exponentially with age (R2=0.957), especially in those over 80 years old; the spatial distribution shows that the injury death rate in the central region is higher than that in the east and west and that in the countryside is higher than that in the city; the distribution of death time shows that after entering an aging society (2000-2020) is significantly higher than before (1990-2000). (3)There are more than 12 types of injury death, and the top three are falling, traffic accidents, and suicide.
Conclusions
China's elderly injury death rate is at a high level in the world, with more males than females, especially after the age of 80. There are regional differences. The main types of injury death are falling, traffic, and suicide. During the 14th Five-Year Plan period, for accidental injuries and death, a rectification list for aging and barrier-free environments was issued.
PROSPERO Registration
The systematic review was registered in PROSPERO under protocol number CRD42022359992.
The Effects of Probiotics on Gastrointestinal Symptoms and Microbiota in Patients with Celiac Disease: A Systematic Review and Meta-Analysis on Clinical Trials
Authors: Mozafarybazargany Mohammadhossein , Khonsari Nami Mohammadian , Sokoty Leily , Ejtahed Hanieh-Sadat , Qorbani Mostafa
Published: January 2023

Objectives
Gluten-free diet (GFD) is the most effective method to manage celiac disease (CD). Many patients do not reach the complete symptom alleviation, even by strict GFD. Recent studies have reported inconsistent results regarding the beneficial benefits of taking probiotics. Therefore, we aimed to evaluate the effects of probiotics on gastrointestinal (GI) symptoms and the possible underlying causes in CD and celiac disease autoimmunity (CDA) patients.
Methods
Databases, including PubMed, Scopus, Embase, Web of Science and Google Scholar were searched for clinical trials published until July 2022 about assessing the effects of probiotics or synbiotics on CD or CDA patients. We collected data on GI symptoms, CD markers, inflammatory and immune responses, adverse events, and gut microbiota. A random effect meta-analysis was used to estimate the pooled standardized mean difference (SMD) and confidence interval (CI).
Results
We screened 7234 articles, of which 14 were included in the qualitative analysis and 5 in the quantitative analysis. Probiotics might alleviate GI symptoms, especially in the highly symptomatic patients and improve immune response in CD and CDA patients. Results of the meta-analysis showed that probiotics increased the abundance of Bifidobacterium (SMD:0.72, 95%CI (0.13,1.30) and Lactobacillus (SMD:0.49, 95%CI (0.18,0.80) as compared with placebo. Probiotics did not increase the adverse events compared to the placebo.
Conclusion
Probiotics might alleviate GI symptoms and immune response and improve dysbiosis in CD and CDA patients. However, high-quality clinical trials are needed to increase the level of evidence. Also, the most suitable combination of probiotics is yet to find.
LncRNA UCA1 promotes keratinocyte inflammation via suppressing METTL14 and activating the HIF-1α/NF-κB axis in psoriasis
Authors: Hu Yibo , Lei Li , Jiang Ling , Zeng Hongliang , Zhang Yushan , Fu Chuhan , Guo Haoran , Dong Yumeng , Ouyang Yujie , Zhang Xiaolin , Huang Jinhua , Zeng Qinghai , Chen Jing
Published: January 2023

Psoriatic inflammation can be regulated by epigenetic factors, but little is known about their role. This work aims to reveal the effects of lncRNA UCA1 in keratinocyte inflammation. UCA1 was a psoriasis-related lncRNA in eight GEO transcriptome datasets and psoriatic skin. When we over-expressed or knocked down UCA1 in the keratinocyte cell line (HaCaT), the transcriptome and proteomic data showed that UCA1 could positively regulate inflammatory functions, such as response to cytokine. Experimental findings confirmed that UCA1 could increase inflammatory cytokine secretion, innate immunity gene expression, and ability of vascular endothelial cells. Besides, UCA1 could activate the NF-κB signaling pathway, which might be the target of UCA1-incuded HIF-1α and STAT3. We then uncovered the direct interactions between UCA1 and N6-methyladenosine (m6A) methyltransferase METTL14. METTL14 proved to be a functional suppressor of inflammation, it could antagonize the functions of UCA1. Subsequently, we found the m6A levels of HIF-1α were decreased in psoriatic lesions, thus HIF-1α could be the target of METTL14. In general, this work indicates that UCA1 can positively regulate keratinocytes inflammation and psoriasis development, it binds METTL14 and then activates HIF-1α and NF-κB signaling pathway. Our work presents a new understanding of UCA1 and METTL14 in psoriatic inflammation.
Use of imaging prediction model for omission of axillary surgery in early-stage breast cancer patients
Authors: Kim Soo-Yeon , Choi Yunhee , Kim Yeon Soo , Ha Su Min , Lee Su Hyun , Han Wonshik , Kim Hong‑Kyu , Cho Nariya , Moon Woo Kyung , Chang Jung Min
Published: January 2023

Purpose
To develop a prediction model incorporating clinicopathological information, US, and MRI to diagnose axillary lymph node (LN) metastasis with acceptable false negative rate (FNR) in patients with early stage, clinically node-negative breast cancers.
Methods
In this single center retrospective study, the inclusion criteria comprised women with clinical T1 or T2 and N0 breast cancers who underwent preoperative US and MRI between January 2017 and July 2018. Patients were temporally divided into the development and validation cohorts. Clinicopathological information, US, and MRI findings were collected. Two prediction models (US model and combined US and MRI model) were created using logistic regression analysis from the development cohort. FNRs of the two models were compared using the McNemar test.
Results
A total of 964 women comprised the development (603 women, 54 ± 11 years) and validation (361 women, 53 ± 10 years) cohorts with 107 (18%) and 77 (21%) axillary LN metastases in each cohort, respectively. The US model consisted of tumor size and morphology of LN on US. The combined US and MRI model consisted of asymmetry of LN number, long diameter of LN, tumor type, and multiplicity of breast cancers on MRI, in addition to tumor size and morphology of LN on US. The combined model showed significantly lower FNR than the US model in both development (5% vs. 32%, P < .001) and validation (9% vs. 35%, P < .001) cohorts.
Conclusion
Our prediction model combining US and MRI lowered FNR compared to using US alone.
Dose frequency randomized control trial for Dynamic Temporal and Tactile Cueing (DTTC) treatment for childhood apraxia of speech: Protocol paper
Authors: Iuzzini-Seigel Jenya , Case Julie , Grigos Maria , Velleman Shelley , Thomas Donna , Murray Elizabeth
Published: January 2023

Background
Childhood apraxia of speech (CAS) is a pediatric motor-based speech sound disorder that requires a specialized approach to intervention. The extant literature on the treatment of CAS commonly recommends intensive treatment using a motor-based approach, with some of the best evidence supporting the use of Dynamic Temporal and Tactile Cueing (DTTC). To date, a rigorous and systematic comparison of high and low dose frequency has not been undertaken for DTTC, resulting in a lack of evidence to guide decisions about the optimal treatment schedule for this intervention. The current study aims to fill this gap in knowledge by comparing treatment outcomes when dose frequency is varied.
Methods
A randomized controlled trial will be conducted to examine the efficacy of low versus high dose frequency on DTTC treatment outcomes in children with CAS. A target of 60 children, 2;6–7;11 years of age, will be recruited to participate in this study. Treatment will be provided in the community setting by speech-language pathologists who have completed specialized training administering DTTC in a research reliable manner. True randomization with concealed allocation will be used to assign children to either the low or high dose frequency group. Treatment will be administered in 1-hour sessions either 4 times per week over a 6-week period (high dose) or 2 times per week over a 12-week period (low dose). To measure treatment gains, probe data will be collected before treatment, during treatment, and 1 day, 1 week, 4 weeks, and 12 weeks post-treatment. Probe data will consist of customized treated words and a standard set of untreated words to assess generalization of treatment gains. The primary outcome variable will be whole word accuracy, encompassing segmental, phonotactic, and suprasegmental accuracy.
Discussion
This will be the first randomized controlled trial to evaluate dose frequency for DTTC treatment in children with CAS.
Trial Registration:
ClinicalTrials.gov identifier NCT05675306, January 6, 2023.
Post-prandial Analysis of Fluctuations in the Platelet Count and Platelet Activity in Patients with the Familial Chylomicronemia Syndrome
Authors: Larouche Miriam , Brisson Diane , Morissette Marie-Claude , Gaudet Daniel
Published: January 2023

Background: The familial chylomicronemia syndrome (FCS) is an ultra rare disease caused by lipoprotein lipase (LPL) deficiency associated with potentially lethal acute pancreatitis risk. Thrombocytopenia (platelet count < 150,000 x 109/L) has been reported in patients with FCS, treated or not with volanesorsen, a second generation APOC3 anti-sense oligonucleotide. Chylomicrons are the lipoproteins delivering fat after a meal and FCS is thus a post-prandial disease. Platelet count and activity have not been studied post-prandially in FCS.
Objective: To evaluate post-prandial fluctuations in the platelet count (PLC) and platelet activity in FCS.
Methods: PLC, platelet activity and hematologic variables were measured up-to 5 hours after a meal in 6 homozygotes for FCS causing gene variants (HoLPL), 6 heterozygotes for LPL loss-of-function variants (HeLPL) and 7 normolipidemic controls.
Results: Hourly post-prandial PLC was significantly lower in HoLPL than in controls (p< 0.009). Compared to the other groups, the PLC tended to decrease rapidly (in the first hour) post-meal in HoLPL (p=0.03) and remained lower than baseline 5-hour post-meal (p=0.02) whereas it tended to slightly increase in normolipidemic controls (p=0.02). Platelet activity was not affected by the prandial status. In HoLPL, post-prandial fluctuations in the PLC positively correlated with the lymphocyte count (p=0.005) and negatively with neutrophil/lymphocyte ratio (NLR).
Conclusion: The PLC decreases post-prandially in FCS (HoLPL), is not associated with changes in platelet activity and correlates with the NLR, a marker of acute pancreatitis severity.
Advantage of contrast-enhanced ultrasound guided sentinel lymph node biopsy in early-stage breast cancer, one node might be enough: a prospective cohort study.
Authors: Cui Qiuxia , Dai Li , Li Jialu , Shen Yang , Tao Huijiang , Zhou Xiaofeng , Xue Jialei
Published: January 2023

Objective
the purpose of this study is proving the contrast-enhanced ultrasound (CEUS) identified sentinel lymph node (SLN) could accurately represent the axillary nodes status in early-stage breast cancer.
Method
A total of 109 consecutive consenting patients with clinical node negative and T1-2 breast cancer were included in this study. All patients received CEUS to identify SLN before surgery and deploying a guidewire to locate the SLN in those who were CEUS explored successfully. All patients underwent sentinel lymph node biopsy (SLNB), and blue dye was also used to help in tracing sentinel lymph node during the surgery. Whether to perform axillary lymph node dissection (ALND) depends on the intraoperative pathological result of the SLN identified by CEUS (CE-SLN). Comparing the pathological results of the CE-SLN with the remaining dyed SLN and axillary dissection nodes.
Result
4 patients was failed to identify the CE-SLN, the detection rate of the CEUS is 96.3%. Among the 105 successful patients, 18 were CE-SLN positive by intraoperative frozen section, another one with CE-SLN micrometastasis was diagnosed by paraffin section. No additional lymph node metastases were found for all CE-SLN negative patients, the false negative rate of CEUS-guided SLNB is 0%.
Conclusion
For patients with clinical node negative and small tumor burden breast cancer, SLN located by CEUS can accurately represent the status of axillary lymph nodes.
Characteristics of biogas production and synergistic effect of primary sludge and food waste co-digestion
Authors: Rakić Nikola , Šušteršič Vanja , Gordić Dušan , Jovičić Nebojša , Bošković Goran , Bogdanović Ivan
Published: January 2023

Co-digestion implementation in wastewater treatment plants reduces waste output and enhances biogas yield. In this regard, the objective of this research was to determine the optimal ratio of biodegradable waste and sewage sludge for co-digestion process in a city plant in central Serbia. The increase in biogas production was investigated through batch tests while synergistic effects were evaluated by chemical oxygen demand (COD) balance. Analyses were performed in four volume basis ratios (3/1, 1/1, 1/3, 1/0) of primary sludge and food waste with added low food waste: 3.375%, 4.675%, and 5.35%, respectively. The best proportion was found to be 1/3 with the highest biogas production (618.7 ml/g VS added) and the organic removal of 52.8% COD elimination. COD reductions further supported the synergistic impact; specifically, an additional 7.1%, 12.8%, and 17% of COD were converted into biogas during the co-digestions 1, 2, and 3, respectively. The rise in co-substrate concentrations was accompanied by a uniform hydrolysis rate constant, the absence of any lag phase, and a greater biogas generation rate. The amount of biogas produced within co-digestions proves to be equivalent to the volume of biogas acquired from individual substrates and the mass of added COD in co-digestions but inversely proportional to the mass of COD utilized in mono-digestion. Further on, specific biogas productions and COD values in digesters show linear dependence. Finally, the study points out that COD method can be used for developing relatively accurate model for biogas potential estimation in wastewater treatment plants.
Evaluation of Choroidal Thickness and Choroidal Vascularity Index in Patients With Crimean Congo Hemorrhagic Fever
Authors: Konuk Şerife Gülhan , Kılıç Raşit , Yılmaz Emine Türkoğlu , Kaya Fatih
Published: January 2023

Purpose: To compare the choroidal thickness parameters of patients with Crimean-Congo Hemorrhagic Fever (CCHF) and healthy subjects using spectral domain optical coherence tomography (SD-OCT).
Methods: In this study, right eye of 27 cases diagnosed with CCHF and 27 healthy subjects were evaluated. CCHF cases were evaluated after history of tick bite and hospitalization. Choroidal thickness was measured using EDI-OCT. Choroidal thickness was measured at five different points at the subfovea, temporal and nasal quadrants at 1000 μm intervals up to 2000 μm from the fovea. Choroidal vascular index (CVI) was defined as the ratio of luminal area (LA) to total choroidal area (TCA), including the total and 1500 μm center of the macula (CVItotal and CVI1500).
Result: Choroidal thickness in CCHF group was measured thicker in each quadrant than in the control group and the thickness in the subfoveal and nasal quadrants was significantly greater. TCA, stromal area (SA), LA were found to be significantly higher, but no significant difference was found between CVI and CVI1500.
Conclusion: Our findings suggest that the choroidal structure may be affected by CCHF disease.
Debond identification in GFRP strengthened RC beam using surface guided wave mode generated by angle beam transducer
Authors: PANT Udita , BANERJEE Sauvik
Published: January 2023

Debonding failure is one of the most common failure modes for FRP-strengthened RC structures. Thus, the strengthened structure requires regular inspections using an efficient and field-friendly technique. This paper proposes the use of angle beam (wedge) transducers to identify the debonded zone in a GFRP-strengthened RC beam. An experimental study is conducted to investigate the capability of wedge transducers to generate and receive the intended mode in the specimen. The inspection is carried out in longitudinal and transverse directions, both using the wedge and normal contact transducers. The normalised signal amplitude versus the sensor position plot is compared for ‘with wedge’ and ‘without wedge’ cases. It is found that the use of a wedge transducer significantly reduces the signal noise, thus improving the debond detection ability compared to the usage of normal transducers. Further, a three-dimensional finite element model is developed to understand the characteristics of wave propagation in the same beam specimen. The modal characteristics and normalised amplitude of signals captured in the numerical model is found in good agreement with the experimental results. The successful numerical validation paves the way for further parametric studies using the model in future work. As this technique does not involve the permanent installation of sensors, it can prove to be a competent technique for rapid in-situ nondestructive evaluation of FRP-strengthened RC structures.
Bibliometric and visual analysis of global research on premium IOLs from 2000 to 2022
Authors: Li Liangpin , Yuan Liyun , Li Qingyu , Cai Maoyu , Zhou Xueyan , Mao Deshen , Hua Xia , Yuan Xiaoyong
Published: January 2023

Background Premium intraocular lenses (PIOLs), particularly those using multifocal, extended depth of focus (EDoF) and toric technologies, have been in clinical use for decades, giving countless cataract patients the ability to see the world clearly again. To explore the development process, research status and future development trends of PIOLs, we explored research on PIOLs from the past 22 years through bibliometrics. Methods The literature search was performed on the Web of Science and included PIOL studies published between 2000 and November 2022. The retrieved literature was collated and analyzed by R-tool's Bibliometrix package, CitNetExplorer, CiteSpace and other software. Results We obtained a total of 1801 articles about PIOLs, most of which were published in Spain and the United States. The organization that published the most articles was the University of Valencia in Spain. Alió JL, and Montés-Micó R, from Spain were the most influential authors in this field. The Journal of Cataract and Refractive Surgery and Journal of Refractive Surgery were the core journals for this field; the top 10 cited articles mainly focus on postoperative satisfaction with multifocal IOLs and postoperative results of toric IOLs. Through a key word analysis, we found that trifocal IOLs, astigmatism and EDoF IOLs are the most discussed topics at present, and the importance of astigmatism and the clinical application of the new generation of PIOL are the emerging research trends. In addition, we found that researchers are not only focusing on the application of cutting-edge technology but also paying increasing attention to patients' subjective satisfaction. Conclusion Bibliometric analysis can effectively help to identify multilevel concerns in premium intraocular lens (PIOL) research and we found that in the past 2 decades, the research of PIOL has made rapid development and gradually matured, countless cataract patients can regain excellent visual quality and improve their quality of life after surgery. The current research hotspots regarding PIOL are the application of EDoF IOL as well as trifocal IOL and its toric models and the development of new types of PIOLs.
Preoperative diagnosis of pulmonary sarcomatoid carcinoma based on CT findings and radiomics
Authors: Tang Wenjian , Wen Chunju , Pei Yixiu , Wu Zhen , Zhong Junyuan , Peng Jidong , Zhong Jianping
Published: January 2023

Background Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small cell lung cancers (NSCLC), but differs in terms of prognosis and treatment strategies. Due to the rarity of PSC, there are few reports focus on the CT radiomics of PSC. However, the preoperative diagnosis of PSC is important and remains challenging. The aim of the study is to explore the feasibility of preoperative differentiation of PSC from other NSCLC based on CT findings and radiomics, so as to improve the accuracy of radiological diagnosis of PSC. Methods 31 patients with PSC and 56 patients with other NSCLC were retrospectively analyzed. CT findings included tumor size, tumor location, calcification, vacuole/cavity, pleural invasion, and low-attenuation area (LAA) ratio. A total of 851 radiomics features were extracted from each CT phase data, including the plain scan (PS), arterial phase (AP) and venous phase (VP). The training and testing cohorts were created in an 8:2 ratio, and the top-ranked 11 features were selected using least absolute shrinkage and selection operator (LASSO) method. Seven machine learning algorithms (DT, GBDT, LDA, LR, RF, SVM, and XGBoost) were applied for the differential diagnosis of PSC and other NSCLC. Results The median survival times of PSC and other NSCLC were 8 months (95% CI 2.123–13.877) and 34 months (95% CI 22.920–45.080), respectively. The mean tumor size of PSC (2.0-9.3 cm) and other NSCLC (2.1–9.7 cm) was 5 cm, and the difference was not statistically significant. Compared to other NSCLC, PSC had a larger LAA ratio (P < 0.001), with an optimal cutoff value of 16.6%, and a sensitivity and specificity of 0.806 and 0.732, respectively. In CT radiomics, PS data combined with logistic regression (LR) algorithm yielded the highest diagnostic efficacy, and the area under the curve (AUC), accuracy, sensitivity and specificity were 0.972, 0.944, 0.833 and 1.000, respectively. Conclusions CT findings and radiomics showed efficient performance in the differential diagnosis of PSC from other NSCLC, which is helpful for the preoperative diagnosis of PSC.
Serum interleukin-1 is a new biomarker to predict the risk of rebleeding of ruptured intracranial aneurysm after admission
Authors: Wen Zheng , Liu Qingyuan , Jiang Pengjun , Zhu Chengcheng , Li Jiangan , Wu Jun , Wang Shuo , Ning Bo
Published: January 2023

Interleukin-1 (IL-1) could induce inflammation of the aneurysm wall, which might be related to intracranial aneurysm rupture. The aim of this study was to investigate whether IL-1 could serve as a biomarker to predict the risk of rebleeding after admission. Data between January 2018 and September 2020 were collected from patients with ruptured intracranial aneurysms (RIAs) and were retrospectively reviewed. The serum IL-1β and IL-1ra levels were detected using a panel, and IL-1 ratio was calculated as the log10(IL-1ra/IL-1β). The predictive accuracy of IL-1 compared with previous clinical morphology (CM) model and other risk factors were evaluated by the c-statistic. 538 patients were finally included in the study, with 86 rebleeding RIAs. The multivariate Cox analysis confirmed aspect ratio (AR) > 1.6 (hazard ratio (HR), 4.89 [95%CI, 2.76–8.64], P < 0.001), size ratio (SR) > 3.0 (HR, 2.40 [95%CI, 1.34–4.29], P = 0.003), higher serum IL-1β (HR, 1.88 [95%CI, 1.27–2.78], P = 0.002) and lower serum IL-1ra (HR, 0.67 [95%CI, 0.56–0.79], P < 0.001) as the independent risk factors for rebleeding after admission. According to the c-statistics, the IL-1 ratio had the highest predictive accuracy (0.82), followed by IL-1ra and IL-1β (0.80), AR > 1.6 (0.79), IL-1ra (0.78), IL-1β (0.74) and SR > 3.0 (0.56), respectively. Subgroup analysis based on AR and SR presented similar results. The model combining IL-1 ratio and CM model showed higher predictive accuracy for the rebleeding after admission (c-statistic, 0.90). Serum IL-1, especially IL-1 ratio, could serve as a biomarker to predict the risk of rebleeding after admission. Unique identifier: ChiCTR1900024406, retrospectively registered.
Satisfaction and Self-Confidence among Nursing Students with Simulation Learning During COVID-19
Authors: Alsadi Mohammad , Oweidat Islam , Khrais Huthaifah , Tubaishat Ahmad , Nashwan Abdulqadir
Published: January 2023

Aim: This survey aimed to investigate nursing students’ satisfaction and self-confidence in simulation in education during the COVID-19 pandemic.
Design: A cross-sectional survey.
Methods: The survey was conducted at the faculty of nursing of a private university in Jordan. Students’ satisfaction and self-confidence levels in simulation learning were measured using the National League for Nursing (NLN) Student Satisfaction and Self-confidence in Learning Scales.
Results: A total of 138 undergraduate nursing students participated in the survey. Students’ satisfaction levels and self-confidence in simulation learning were lower (just above the midpoint of the scale) than scores reported in similar surveys. The lowest student ratings were reported as “the variety of learning activities that can be done using simulation” and “the self-confidence to develop the needed skills and knowledge to be used in real clinical settings”. The results also indicated that as students progress in the bachelor’s degree program, they develop higher levels of self-confidence in simulation learning.
Conclusions: Nursing students' experience of simulation learning was affected by the COVID-19 pandemic, showing the need for high-fidelity simulation. Education stakeholders are invited to invest in the resources of high-fidelity simulation to maximize its benefits and help in the recovery phase after the pandemic.
Low hepatic artery resistive index on the first post-transplant day is associated with inferior graft survival in adult liver transplantation
Authors: Capra Rodrigo P. , Lazzarotto-da-Silva Gabriel , Grezzana-Filho Tomaz J. M. , Viana Gabriel S. , Prediger João E. , Rabolini Bruno , Silva Rafaela K. , Prediger Lucas , Araujo Alexandre , Alvares-da-Silva Mario R. , Feier Flavia H. , Chedid Marcio F. , Kruel Cleber R. P.
Published: January 2023

Purpose
Although liver transplantation (LT) outcomes have improved significantly over the last decades, early post-transplant vascular complications are still associated with an elevated risk of graft failure. Doppler ultrasound (DUS) enables detection of vascular complications and provides hepatic artery Resistive Index (RI). The aim of our study was to evaluate the association of the RI parameters of DUS performed in the first post-transplant week with post-transplant outcomes.
Methods
All consecutive patients undergoing a first LT between 2001 and 2019 at a single center were included. P were divided into three groups: RI < 0.55, RI 0.55–0.85 and RI > 0.85. Patients were also divided according to the presence or absence of hepatic artery thrombosis (HAT). Graft survival was compared among groups.
Results
Three hundred and forty-four patients were included. HAT occurred in 23 patients (6.7%), of which 7 were partial and 16 were complete. Biliary complications were more common in patients with HAT (11 [47.8%]) vs. 44 [13.4%] [p < 0.001]). There was no statistically significant difference in graft survival between patients with and without HAT. Patients with RI < 0.55 on post-operative day 1 had worse graft survival compared to patients with RI 0.55–0.85 and RI > 0.85. RI on post-operative day 3 and 5 was not predictive of graft survival.
Conclusions
The use of DUS on liver transplant recipients in the early post-transplant period offers the possibility of early diagnosis of vascular complications. Additionally, according to our data, low RI (< 0.55) on the first postoperative day also provides prognostic information regarding graft-survival.
The 3Po states of exotic molecular ions with exponential-cosine-screened Coulomb potentials
Authors: Fu Xin Yan , Jiang Zishi , Kar Sabyasachi
Published: January 2023

We investigate the bound states, Borromean states and resonant states for the 3Po (J = 1) states of \(pp\mu\), \(dd\mu\) and\(tt\mu\) molecular ions interacting with exponential-cosine-screened Coulomb potential. The bound 3Po state energies are calculated using the Rayleigh-Ritz variational method and the resonance parameters are calculated using the stabilization method. Highly correlated exponential wave functions are used. The bound 3Po state energies, the 3Po resonance parameters (energy and width), along with 1S and 2S threshold energies of the \(p\mu\), \(d\mu\) and\(t\mu\) atoms are also reported for different shielding parameters. The critical values of the screening parameters for the 3Po states are also reported for which the three-body exotic molecular systems are stable while all the possible fragments are unbound, that is shows windows for Borromean binding.
Early and sustained efficacy of fremanezumab over 24-weeks in migraine patients with multiple preventive treatment failures. The multicenter, prospective, real-life FRIEND2 study.
Authors: Barbanti Piero , Egeo Gabriella , Aurilia Cinzia , Torelli Paola , Finocchi Cinzia , d'Onofrio Florindo , d'Onorio Luigi , Rao Renata , Messina Stefano , Clemente Laura Di , Ranieri Angelo , Autunno Massimo , Sette Giuliano , Colombo Bruno , Carnevale Antonio , Aguggia Marco , Tasillo Miriam , Zoroddu Francesco , Frediani Fabio , Filippi Massimo , Fiorentini Giulia , Tomino Carlo , Proietti Stefania , Bonassi Stefano
Published: January 2023

Background
To verify the long-term (24-week) efficacy, safety, and tolerability of fremanezumab in real-life patients with high-frequency episodic migraine (HFEM: ≥8 days/month) or chronic migraine (CM: ≥15 days/month), and multiple preventive treatment failures.
Methods
This is a prospective, cohort, real-life study at 28 headache centers on consecutive patients affected by HFEM or CM with multiple preventive treatment failures who were prescribed subcutaneous fremanezumab (225 mg monthly/675 mg quarterly) for ≥ 24 weeks. Primary endpoint was the change in monthly migraine days (MMDs) in HFEM and monthly headache days (MHDs) in CM at weeks 21–24 compared to baseline. Secondary endpoints encompassed changes in monthly analgesic medications, ≥ 50%, ≥ 75%, and 100% responder rates, and variation in NRS, HIT-6 and MIDAS scores at the same time interval. Changes in MMDs/MHDs, monthly analgesic medications, ≥ 50%, ≥ 75%, and 100% responder rates, and variation in NRS and HIT-6 scores at week 4 were also monitored.
Results
410 patients who had received ≥ 1 dose of fremanezumab were considered for safety analysis while 148 patients treated for ≥ 24 weeks were included in the efficacy analysis. At weeks 21–24, fremanezumab significantly (p < 0.001) reduced MMDs, MHDs, monthly analgesic medications and NRS, HIT-6, and MIDAS scores in both HFEM and CM compared to baseline. The proportions of ≥ 50%, ≥ 75% and 100% responders at weeks 21–24 were 75.0%, 30.8%, 9.6% (HFEM), and 72.9%, 44.8% and 1% (CM). A significant (p < 0.001) decrease in MMDs, MHDs, monthly analgesic medications and NRS, HIT-6, and MIDAS scores in both HFEM and CM was already present at week 4. The proportions of ≥ 50%, ≥ 75%, and 100% responders at week 4 were 67.6%, 32.4%, 11.8% (HFEM) and 67.3%, 40%, 1.8% (CM). CM remitted to episodic migraine and medication overuse to no-medication overuse in 83.3% and 75% of patients at week 24, and in 80% and 72.4% at week 4. Adverse events were rare (2.4%), mild and transient. No patient discontinued treatment for any reason.
Conclusions
Fremanezumab is characterized by an early and sustained efficacy in HFEM and CM patients with multiple preventive treatment failures in real-life, revealing an optimal safety and tolerability profile.
Return of Participants' Incidental Genetic Research Findings: Experience from a Case-Control Study of Asthma in an American Indian Community
Authors: Best Lyle G. , O'Leary Marcia , O'Leary Rae , Lawrence Wendy , Torgerson Dara G.
Published: January 2023

Purpose: The proper communication of clinically actionable findings to participants of genetic research entails important ethical considerations, but has been challenging for a variety of reasons. We document an instance of return of individual genetic results in the context of a very rural American Indian community, in hopes of providing insight to other investigators about potentially superior or inferior courses of action.
Methods: The original study was a case/control study of asthma among 324 pediatric participants. The study utilized a genotyping microarray assessing over 2 million variants, including one conferring risk for hypertrophic cardiomyopathy for which the American College of Medical Genetics recommends return of results to participants. The study investigators engaged in extensive consultation with the IRB, the Tribal government and local clinicians to better inform our approach.
Results: With some difficulty we were able to notify the 2 participants heterozygous for this variant. One participant welcomed this information and proceeded to obtain further clinical work-up; the other participant declined further follow-up.
Conclusion: While demanding of considerable time and effort, the return of clinically actionable genetic results is important from both an ethical perspective and to provide an improved trust relationship with the community of research participants.
Practical biomarkers and robust multiplex models for the prediction of response to the promising first-line chemotherapy: A theranostic study in metastatic ovarian cancer patients with residual peritoneal tumors
Authors: Kawabata-Iwakawa Reika , Iwasa Norihiro , Satoh Kenichi , Colinge Jacques , Shimada Muneaki , Takeuchi Satoshi , Fujiwara Hiroyuki , Eguchi Hidetaka , Oishi Tetsuro , Sugiyama Toru , Suzuki Mitsuaki , Hasegawa Kosei , Fujiwara Keiichi , Nishiyama Masahiko
Published: January 2023

Background: In advanced or metastatic ovarian cancer patients, the therapeutic impact of molecular targeted agents and immunotherapy is limited, and current chemotherapeutic algorithm is still far from personalized medicine. We recently demonstrated that intraperitoneal carboplatin with dose-dense paclitaxel (ddTCip) therapy is a promising front-line chemotherapy even in the patients with residual peritoneal tumors, which led us to this theranostic study for biomarker discovery to realize the precision medicine (ID: UMIN000001713 on Feb 16 th , 2009). Methods: We first validated previously suggested markers (41 genes and 3 predictive models for the therapeutic efficacy and 31 polymorphisms for the toxicity), sought out more active effective biomarkers through genome-wide transcriptome and genotyping analyses, and then developed multiplex statistical prediction models for progression free-survival (PFS) and toxicity. Multiple regression analysis following forward stepwise method and Classification and Regression Trees (CART) algorithm were mainly employed to develop multiplex prediction models. Results: The association analyses with PFS in 76 patients followed by the validation study using data sets in 189 patients published in The Cancer Genome Atlas revealed that SPINK1 expression could be a possible predictive biomarker of ddTCip efficacy even when used alone, and multiple regression analyses provided a potent efficacy prediction model using expression data of 5 genes. SPINK1 appeared to be a critical resistant determinant of ddTCip therapy, which indicates the potential of SPINK1 also to be a novel therapeutic target. As for the toxicity prediction, ABCB1rs1045642 and ERCC1rs11615 polymorphisms appeared to closely associate with grade2-4 hematologic toxicity and peripheral neuropathy, respectively. We further successfully composed robust multiplex prediction models for the adverse events-CART models using a total of 4 genotype combinations and further powerful multiple regression models using 15 polymorphisms on 12 genes-. Conclusions: We newly proposed SPINK1 expression as a powerful predictive biomarker of the efficacy for ddTCip therapy and confirmed the predictive values of ABCB1 and/or ERCC1 polymorphisms for the toxicity. Multiplex prediction models composed herein were also found to work well for the prediction of therapeutic response. These may raise the potential to realize a precision medicine in the essential treatment for metastatic ovarian cancer patients.