bluuebunny/crossref_metadata_2025 huggingface dataset:
Разработка автоматизированной системы управления проектами для малых предприятий
Authors: Шавтикова Л.М. , Боташев Т.А.
Published: May 2023

В статье рассматривается актуальная тема разработки системы управления проектами, использование которой на небольших предприятиях позволит увеличить эффективность работы персонала.
Косметология как наука (обзорная статья)
Authors: Аймукамбетова Д.К. , Розыева Р.С. , Темиров Н.М
Published: May 2023

Обзорная статья посвящена проблеме современного состояния оказания косметологических услуг населению и необходимости ее модернизации. В этой связи рассматриваются определения здоровья, образа и качества жизни, удовлетворенности условиями жизни как базовые элементы уровня комфортности. С учетом мирового опыта, показана необходимость разработки и внедрения научно-обоснованной – с организационнометодических позиций – системы объективной оценки качества оказываемой косметологической помощи и ее стандартизации, а также разработки критериев оценки деятельности профильных медицинских организаций. Выделены три главных направления работы по обеспечению качества медицинской помощи (по А. Донабедиани): совершенствование и взаимосвязь структуры, процесса и результата. Рассмотрен вопрос о целесообразности информатизации в косметологии и организации косметологической помощи с учетом социально-экономической обстановки в стране и потребности населения.
Анализ соответствия самооценки уровня знаний и рейтинга, полученного обучающимися на занятиях по дисциплине «Биохимия»
Authors: Даниловцева А.В. , Каминская Л.А.
Published: May 2023

В статье представлены результаты самооценки студентами 2 курса лечебного факультета своих знаний по трем темам дисциплины «Биохимия»: энзимология (3 вопроса), обмен углеводов (4 вопроса), обмен липидов (3 вопроса). Проведено сравнение данных рейтинга учебного процесса по указанным модулям и рейтинги самооценки общего массива анкетированных и отдельных групп. Выявлено совпадение мнений студентов и преподавателей о сложности и недостаточном усвоении ряда тем. Полученная информация выявляет пути усовершенствования методики проведения занятий, может способствовать индивидуальному подходу в организации учебного процесса в академических группах.
Динамика изменений биохимических процессов в пожилом и старческом возрасте в разные времена года
Authors: Жалалова Г.Т. , Жолдошев С.Т.
Published: May 2023

В статье отражено изучение влияния климатических и сезонных факторов на организм людей пожилого и старческого возраста. Эти факторы значительно усугубляют течение многих заболеваний, ухудшают самочувствие и снижают работоспособность организма. Они также влияют на изменение биохимических процессов в организме человека. Известно, что не отдельные метеорологические факторы или конкретный тип погоды, а разница двух резко меняющихся погод вызывает повышенные требования к адаптационным и регуляторным аппаратам человека. Липиды играют важную роль в обменных процессах в различных органах, в том числе и в печени. Пожилой и старческий возраст резко реагируют на сезонные колебания, и все это проявляется различными функциональными изменениями в системах организма. Жители Оша и Ошской области адаптировались к более высоким температурам. Выявлены особенности изменения параметров жирового обмена у лиц пожилого и старческого возраста в разные периоды года.
Влияние рациона питания на состав тела у иностранных и российских студентов
Authors: Зубова Е.О. , Миронова А.С. , Волкова Д.А. , Набатова М.А. , Негеля Л.А.
Published: May 2023

В статье указаны результаты исследования рациона питания российских и иностранных девушек из Индии и состава их тела. Оценивались особенности питания при помощи анкетирования, состав тела определялся методом биоимпедансометрии, также проводили антропометрические исследования. Выявлены статистически значимые различия в рационе питания, однако статистически значимых различий в составе тела выявлено не было, но обозначились тенденции более низкой мышечной массы тела и основным обменом у студенток из Индии.
Диагностика пародонта системой Florida Probe
Authors: Костригина Е.Д. , Жданова С.С. , Небылицин И.В. , Романова В.С.
Published: May 2023

В статье рассматривается система «Florida Probe», которая представляет собой принципиально новую технологию, основанную на использовании последних компьютерных достижений в современной стоматологии.
Рецессия десны, симптоматика и лечение
Authors: Костригина Е.Д. , Жданова С.С. , Небылицин И.В. , Сажнева Е.Д.
Published: May 2023

Рецессия десны – это патологический невоспалительный процесс, который характеризуется уменьшением количества тканей десны и апикальным смещением десневого края с оголением шеек и корней зубов. Нарушает эстетику улыбки и доставляет психологический дискомфорт пациенту.
Изменения системы свободнорадикального окисления у больных с носовыми кровотечениями
Authors: Паршикова Н.В. , Сорока Г.Г. , Литвинова Л.Н
Published: May 2023

Тяжесть состояния больных с носовыми кровотечениями (НК) определяется не только степенью кровопотери, но и адаптационными возможностями к тканевой адаптации. Цель работы - изучение адаптационных возможностей системы антиоксидантной защиты у больных с НК на фоне гипертонической болезни. Установлено, что исходное соотношение процессов пероксидации и антиоксидантной емкости крови может явиться ключевым моментом в обеспечении газотранспортной функции крови и развитии гипоксии.
Нанотромболизис: современные способы доставки фибринолитиков
Authors: Собянин А.В. , Кудлай Ю.В
Published: May 2023

Тромболитические средства используются в течение нескольких десятилетий для лечения тромботических и тромбоэмболических состояний, существует потребность в разработке более безопасных тромболитических средств. Разработка и синтез новых молекул могут оказаться недостаточными. Это вызывает растущий интерес к разработке новых наноразмерных систем-носителей лекарств для таргетной доставки тромболитических ферментов в попытке устранить их нежелательные побочные эффекты. Существует множество подтверждающих концепцию отчетов о таких наноразмерных системах, которые стремятся извлечь выгоду из патофизиологических признаков тромбоза, а также внешних биохимических / физических триггеров. Хотя прежде чем подобные наноразмерные терапевтические средства будут внедрены в практику, может пройти достаточно длительное время, последние исследования показывают не только реальность таких нанотромболитиков, но и предвосхищают их эффективность. Поэтому в данном обзоре проведен анализ научной информации о тромболитиках и современных способах доставки тромболитических препаратов с целью определния перспективы дальнейших исследований.
Оценка экологической устойчивости различных форм и сортов вишни на основе мониторинга эндофитной микробиоты
Authors: Козаева М.И.
Published: May 2023

На основе изучения состава и особенностей развития эндофитной микробиоты осуществлена диагностика адаптационной способности различных форм и сортов вишни. Выделены формы, представляющие практический интерес для дальнейшей селекции и промышленного садоводства.
Влияние повышенных температур на механические характеристики бетона и фибробетона
Authors: Николаева Т.А.
Published: May 2023

Рассматривается влияние повышенных температур на механические характеристики бетона и фибробетона. Изучается влияние на поведение бетона таких факторов, как вид фибры, размер, форма, диаметр, процент армирования образца; материал заполнителя, его размер, количество, водоцементное отношение бетонной смеси; характер нагрева, его продолжительность; характер охлаждения; количество циклов изменения температур. Проведена оценка и анализ информации о прочностных и деформационных характеристиках бетона, армированного стальной фиброй в сравнении с характеристиками бетона неармированного, как итог выделены факторы, как положительного, так и отрицательного влияния фибрового армирования на свойства материала.
Dynamics of endothelial function indexes in patients with post-Covid syndrome using a combination drug of ethylmethylhydroxyperidine succinate/vitamin B6
Authors: Mikhailova Larisa V. , Belousova Yana D. , Moiseeva Ekaterina M. , Tsapkova Alina A. , Gazatova Natalya D. , Plotnikova Alexandra R. , Rudev Danila G. , Doktorova Svetlana A. , Rafalskiy Vladimir V.
Published: May 2023

Introduction: After the COVID-19 pandemic, public healthcare has faced a new problem, the persistence of symptoms, the most significant of which is undue fatigue. The definition of coronavirus infection as an endothelial disease suggests a possible relationship between asthenic syndrome and endothelial dysfunction.

Aim: to evaluate endothelial function in patients after COVID-19 before and after treatment with combination drug of ethylmethylhydroxyperidine succinate (EMHPS)/vitamin B6.

Materials and Methods: A prospective study included 33 participants, 82% women and 18% men aged 22 to 68 years after COVID-19. There were two site visits made in the course of the study and a 4-week treatment course between the visits.

Results: After the treatment, the index of endothelium-dependent vasodilation increased in women and decreased in men. The differences were statistically insignificant. The number of subjects with a normal level of endothelium-dependent vasodilation increased from 7 to 11 after the treatment. The index of vascular wall stiffness corresponded to the mean age of the examined participants and did not statistically change, although women tended to decrease stiffness and men to increase it. The initial level of nitric oxide was lower in women and statistically significantly increased after treatment, while it remained unchanged in men.

Discission: The study confirms a prolonged course of the post-covid. We assume that the virus destroys endothelial cells.Endothelial dysfunction is known to be associated with an increased cardiovascular risk.

Conclusion: The indicators of endothelial function changed in patients after treatment with the drug. It is necessary to perform endothelial function studies in more patients after COVID-19.

Graphical Abstract
An analysis of India’s export potential in South Asia under SAFTA
Authors: Sharma Vipin , Sharma Anand
Published: May 2023

There is a consensus in the literature that higher exports are associated with increased economic growth, productivity, and employment. This paper attempts to analyze India’s export potential in the South Asian region following the South Asian Free Trade Area (SAFTA) agreement. Using panel data, an augmented gravity model analysis is employed for the period from 2004 to 2021. The analysis finds a positive and significant effect of trading countries’ gross domestic product (GDP) on India’s total exports, whereas the effect of the per capita GDP differential between the countries is negative. This paper does not find any significant effect of distance, border, or common language on India’s total exports. The study also finds that from 2004 to 2021, India’s average export potential was positive with three countries (Pakistan, Bangladesh, and the Maldives) and negative with four countries (Nepal, Sri Lanka, Afghanistan, and Bhutan). India had the highest export potential with Pakistan during this period. The study suggests that India must raise its exports to those South Asian Association for Regional Cooperation (SAARC) member nations where it has not been able to export in accordance with its potential and explore trade opportunities with other countries in Asia, Europe, and North America. In this context, it is crucial to focus on trade and infrastructural reforms to boost India’s exports.
A Capoeira e o Huka- huka nas aulas de educação física: diálogos sobre uma escola plural através das lutas de matriz africana e indígena
Authors: Monteiro Fernanda Yully Dos Santos
Published: May 2023

O texto em tela busca trazer a tona o debate das lutas nas aulas de educação física, mais especificamente das lutas de matriz africana e indígena como possibilidade de um ensino plural que coloque em destaque culturas comumente subvalorizadas. Trata-se de uma pesquisa bibliográfica de cunho explicativo que utiliza como método de interpretação de dados a análise de conteúdo baseada em Triviños (1987). Conclui-se que as vivências com a capoeira e o huka-huka nas aulas de educação física da educação básica além de legitimar outros conteúdos possíveis dentro da área, apontam uma perspectiva de pluralidade de ideias e culturas, dando destaque a culturas que ainda hoje são subvalorizadas dentro do ambiente escolar.
METODOLOGIAS DO ENSINO DE LITERATURA NO 3º ANO DO ENSINO MÉDIO: O CASO DE UMA ESCOLA PRIVADA DE ANANINDEUA/PA
Authors: Aviz Larissa Da Silva Costa
Published: May 2023

O presente trabalho tem como objetivo abordar as metodologias do ensino de literatura no Ensino Médio, em uma escola particular de Ananindeua (PA), na região metropolitana da capital paraense, por meio de reflexões acerca da prática docente nessa disciplina. A fundamentação teórica utilizada foi o estudo das obras Do mundo da leitura para a leitura do mundo de Marisa Lajolo, A arte de ler de Michéle Petit, Ouvir nas entrelinhas de Cecília Bajour, Literatura em Perigo de Tzvetan Todorov e a tese Retrato de uma disciplina ameaçada: a Literatura nos documentos oficiais e no Exame Nacional do Ensino Médio de Gabriela Luft. Para isso, realizou-se uma pesquisa de campo mediante a aplicação de um questionário aos professores responsáveis pela turma do 3º ano acerca dos seus métodos de ensino e também houve a aplicação de um questionário aos alunos sobre as suas perspectivas acerca da matéria. Foi possível observar certa distância entre os ideais de ensino propostos, as metodologias aplicadas e a percepção dos estudantes.
AÇÃO DECLARATÓRIA DE CONSTITUCIONALIDADE Nº 41/2017: AS COTAS PARA NEGROS EM FOCO
Authors: Machado Maricelia Cristiam Lopes
Published: May 2023

A constitucionalidade da Lei de cotas para negros em concursos públicos é cenário de debates, discussões e controvérsias, acerca do Tema. O assunto é tratado na Lei 12.990/2014. Em 2016 o Conselho Federal da OAB ajuizou ação declaratória de constitucionalidade (ADC nº 41) em defesa da Lei nº 12.990/2014 pedindo que o STF declarasse esta norma compatível com a CF/88. Em 2017 o STF julgou procedente a ADC, declarando a constitucionalidade da Lei nº 12.990/2014. Desde a entrada em vigor da mencionada Lei que obriga a Administração Pública Federal de todos os poderes da União a reservarem vagas aos candidatos negros, vários concursos Federais já foram realizados e finalizados e previram nos seus editais as reservas de 20% das vagas ofertadas nos certames.  Nesse contexto, surge o presente trabalho, que tem como escopo primordial disseminar informações fundamentadas à comunidade acadêmica, acerca da ação afirmativa de reserva de vagas para negros em concursos públicos e discutir por que houve a necessidade de se arguir pela Declaração de Constitucionalidade da Lei de Cotas para concurso Público. E ainda, se há a necessidade de Lei de Cotas no Brasil. Se é possível excepcionalizar o principio da igualdade constitucional, caso positivo, sob qual fundamento e também discutir sobre quais as dificuldades enfrentadas ainda hoje em relação às cotas nos concursos públicos. A metodologia utilizada foi a pesquisa bibliográfica em fontes primarias e secundárias.
Enseñanza del mapuzugun en Chile: ecosonoridad como apresto a la adquisición de la lengua indígena
Authors: Rivas Rivas María Clara , Del Pino Miguel
Published: May 2023

La investigación se centró en conocer el proceso de adquisición de la lengua indígena mapuce para su enseñanza y aportar a los actuales programas de lengua mapuzugun. Se trabajó con la metodología participativa dialógica-kishu kimkelay ta che- con profesorado y miembros de la comunidad mapuce de una escuela rural de la Región de La Araucanía, Chile. Como resultados se observa la ecosonoridad como apresto para la enseñanza de la lengua indígena, que concierne a la relación sonido-acción, onomatopeya-toponimia y naturaleza-lengua. Estos resultados se asumen como un desafío necesario para ayudar a mejorar los programas de lengua indígena, debido que, como argumentamos, estos están bajo una lógica mayoritariamente occidental que dificulta la articulación intercultural en las escuelas.
El gobierno colonial de Lima y su capacidad de manejo de la crisis frente al terremoto de 1687: respuestas del virrey y del cabildo secular
Authors: Mansilla Judith
Published: May 2023

En las últimas décadas, los investigadores han debatido sobre la representación tradicional de la administración española durante el siglo XVII como ineficaz e impotente. Algunos de ellos argumentan que el régimen del último rey Habsburgo fue decadente e ineficaz. En contraposición a esta imagen,los administradores reales de Lima, capital del Virreinato del Perú, mostraron una gran capacidad de organización y manejo de la crisis después de queun intenso terremoto y posterior tsunami azotaron la ciudad y su puerto en1687. En medio del caos y la destrucción causada por este desastre natural,el virrey y los miembros del cabildo de la ciudad fueron capaces de usar loslimitados recursos disponibles y de atender las crecientes demandas materiales y espirituales de la población de Lima.
Üniversite Öğrencileri için Başarı Hedefi Yapılarının Psikometrik Özellikleri: Yükseköğretimde Öğrenme Motivasyonu Ölçeği (EMAPRE-U) Geçerlik ve Güvenirlik Çalışması
Authors: ERDURAN TEKİN Özge
Published: May 2023

Bu çalışma Yükseköğretimde Öğrenme Motivasyonu Ölçeği’nin Türk kültüründeki geçerlik ve güvenirliğini inceleyerek, üniversite öğrencileri örnekleminde ölçeği Türkçe’ye uyarlamayı amaçlamaktadır. Araştırmanın çalışma grubunu ölçeğin dilsel eş geçerliğini, eşdeğer ölçek geçerliğini, test tekrar test güvenirliğini inceleyebilmek, açımlayıcı ve doğrulayıcı faktör analizi yapabilmek amacıyla yaş aralıkları 19 ile 35 arasında değişen toplam 1325 (554 kadın ve 770 erkek) kişi oluşturmaktadır. Araştırmada veri toplama için Yükseköğretimde Öğrenme Motivasyonu Ölçeği ve Akademik Özyeterlik Ölçeği’nden yararlanılmıştır. Veriler açımlayıcı ve doğrulayıcı faktör analizi, korelasyon analizi ve bağımsız gruplar için t testi ile incelenmiştir. Yürütülen açımlayıcı faktör analizi sonucunda ölçeğin üç faktörlü yapıdan meydana geldiği belirlenmiştir. Doğrulayıcı faktör analizi ise belirlenen yapının doğrulandığını göstermiştir. Ölçeğin öğrenme, yaklaşma ve kaçınma hedefleri alt boyularının akademik özyeterlik puanları ile ilişkili olduğu ve ölçeğin eşdeğer ölçek geçerliğine sahip olduğu görülmüştür. Yapılan güvenirlik analizleri sonucunda alt boyutların Cronbach alfa katsayısı açımlayıcı faktör analizi yapılan çalışma grubunda .82 ile .87 arasında, doğrulayıcı faktör analizinin yapılan grupta .79 ile .82 arasında değişmektedir. Test tekrar test analizini sonucunda ölçeğin alt boyutları ön ve son test puan ortalamaları arasında pozitif ve yüksek düzeyde ilişkiler olduğu görülmüştür. T testi sonuçlarına bakıldığında ölçeğin ön ve son test puan ortalamaları arasında anlamlı miktarda bir farklılık olmadığı görülmüştür. Ayrıca yapılan analizler sonucunda ölçeğin alt boyutlarından alınan puanlar cinsiyete göre anlamlı bir farklılık göstermemiştir. Elde edilen bu sonuçlara göre Yükseköğretimde Öğrenme Motivasyonu Ölçeği’nin geçerli ve güvenilir olduğu söylenebilir.
An overview of energy management using fuzzy cognitive maps
Authors: Papageorgiou Elpiniki I. , Groumpos Peter
Published: May 2023

Soft computing, especially fuzzy cognitive maps (FCMs), has become increasingly applicable to energy management and policy-making. In recent decades, there has been a worldwide effort to minimize energy consumption and manage energy flow in private and public buildings. We present a critical overview of today’s applications of FCM-based methods in the energy domain. We analyzed FCM methods related to energy planning, efficiency, sustainability, transition, forecasting, energy policy, and scenario analysis. We highlight FCM's applicability in the energy domain, especially its contribution to the academic and research communities. Specific drawbacks and limitations were identified while using FCM methods on several challenging applications, primarily when learning algorithms are used. A new approach addressing these issues is provided and defined as the advanced fuzzy cognitive maps (AFCM) approach. These drawbacks are considered when providing future research challenges of FCMs for building energy management and efficiency. Finally, research gaps are identified, and we suggest solutions, especially AFCM is advanced fuzzy cognitive maps.
Genomics in leukaemia in clinical practice: past, present and the future
Authors: Leung Ho Ching , Leung Anskar Y. H.
Published: May 2023

Acute myeloid leukaemia (AML) is a heterogeneous group of diseases with diverse genetic drivers. The conventional one-size-fits-all approach with chemotherapy and allogeneic hematopoietic stem cell transplantation (HSCT) has reached an impasse, and only about 40% of patients can achieve long-term survival. Disease heterogeneities have also hampered the development of effective therapy applicable to the multitude of AML subtypes. Recent advances in cancer genetics and genomics have shed light on the genetic underpinnings of AML and both inter-individual and intra-tumoral heterogeneities. These new pieces of knowledge have begun to impact the management and prognostication of AML. They also provide the foundation for personalized treatment for this group of diseases.
The Quantization of Mass
Authors: Garrigues-Baixauli José
Published: May 2023

Abstract The value of the mass of the particles is one more mystery that current theories cannot predict, so they have to be determined experimentally. In this paper we will see how the quantization of 4D space gives rise to the quantization of mass and, in turn, the quantization of mass implies that space-time is discrete.
KRAS-dependency in Pancreatic Ductal Adenocarcinoma: Mechanisms of Escaping in Resistance to KRAS Inhibitors
Authors: Gurreri Enrico , Genovese Giannicola , Perelli Luigi , Agostini Antonio , Piro Geny , Carbone Carmine , Tortora Giampaolo
Published: May 2023

Pancreatic ductal adenocarcinoma (PDAC) is still one of the deadliest cancers in Oncology be-cause of its increasing incidence and poor survival rate. More than 90% of PDAC patients are KRAS mutated (KRASmu), with KRASG12D and KRASG12V being the most common mutations. Despite this critical role, its characteristics have made direct targeting of the RAS protein ex-tremely difficult. KRAS regulates development, cell growth, Epigenetically-dysregulated differ-entiation, and survival in PDAC through activation of key downstream pathways, such as MAPK-ERK and PI3K-AKT-mammalian target of rapamycin (mTOR) signaling, in a KRAS-dependent manner. KRASmu induces the occurrence of Acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN) and leads to an immunosuppressive tumor microenvironment (TME). In this context, the oncogenic mutation of KRAS induces an epigenetic program that leads to the initiation of PDAC. Several studies have identified multiple direct and indirect inhibitors of KRAS signaling. Therefore, KRAS dependency is so essential in KRASmu PDAC that cancer cells have secured several compensatory escape mechanisms to counteract the efficacy of KRAS inhibitors, such as activation of MEK/ERK signaling or YAP1 upregulation. This review will provide insights into KRAS dependency in PDAC and analyze recent data on inhibitors of KRAS signaling, focusing on how cancer cells establish compensatory escape mechanisms.
Risk in Times of Crisis and Non-crisis
Authors: Peter Nina
Published: May 2023

Risk protection and precaution are noticeable present, especially in times of a pandemic like Covid 19. However, it is not only in times of abruptly upcoming and unexpected situations like Corona that companies and economic entities are exposed to opportunities and threats. Internal and external developments that could influence the organization’s aims are defined as risks. Hence, it is important to emphasize that every operational activity is associated with risks and is consequently a challenge for companies. The purpose of this paper is to contribute to the identification and classification of individual risks. In this regard, the objectives and relevance of risk management are highlighted. Through the accomplishment of a classic literature review and the application of a comparative methodology the procedure of how hedging instruments are applied, is elaborated. The analysis indicates that various business concerns have a high awareness of risks inherent in business transactions, although they are still very hesitant to insert hedging instruments. Their uncertainties consist in defining and classifying the relevant risks plus identifying the appropriate hedging methods for them. Thus, this research can add new dimensions to hedging transactions and, particularly, express the benefits and opportunities of hedge accounting.
Research on Multilingual News Clustering Based on Cross-Language Word Embeddings
Authors: Wu Lin , Li Rui , Lam Wong-Hing
Published: May 2023

In today's world, news events are emerging incessantly. Classifying the same event reported by different countries is of significant importance for public opinion control and intelligence gathering. Due to the diverse types of news, relying solely on translators would be costly and inefficient, while depending solely on translation systems would incur considerable performance overheads in invoking translation interfaces and storing translated texts. To address this issue, we mainly focus on the clustering problem of cross-lingual news. To be specific, we use a combination of sentence vector representations of news headlines in a mixed semantic space and the topic probability distributions of news content to represent a news article. In the training of cross-lingual models, we employ knowledge distillation techniques to fit two semantic spaces into a mixed semantic space. We abandon traditional static clustering methods like K-Means and AGNES in favor of the incremental clustering algorithm Single-Pass, which we further modify to better suit cross-lingual news clustering scenarios. Our main contributions are as follows: (1) We adopt the English standard BERT as the teacher model and XLM-Roberta as the student model, training a cross-lingual model through knowledge distillation that can represent sentence-level bilingual texts in both Chinese and English. (2) We use the LDA topic model to represent news as a combination of cross-lingual vectors for headlines and topic probability distributions for content, introducing concepts such as topic similarity to address the cross-lingual issue in news content representation. (3) We adapt the Single-Pass clustering algorithm for the news context to make it more applicable. Our optimizations of Single-Pass include adjusting the distance algorithm between samples and clusters, adding cluster merging operations, and incorporating a news time parameter.
High-Conductive CSH2PO4 Membranes with PVDF-Based Polymers Additives for Solid Acid Fuel Cells
Authors: Bagryntseva Irina Nikolaevna , Ponomareva Valentina Georgievna , Kungurtsev Yuri Evgenyevich
Published: May 2023

The proton conductivity, phase composition and mechanical properties of (1-x)CsH2PO4–x fluoropolymer electrolytes (x-mass fraction, x=0-0.3) have been investigated firstly and discussed. UPTFE and PVDF-based polymers (F2M, F42, SKF26) with the high mechanical properties and thermal stability have been chosen as a fluoropolymer additive. According the XRD data, a monoclinic CsH2PO4 (P21/m) phase is retained in all compositions of the polymer electrolytes studied. The conductivity of (1-x)CsH2PO4-x fluoropolymer in the high-temperature phase decreases by approximately one order of magnitude compared with the pure CsH2PO4 for x~0.15-0.20. The size and shape of CsH2PO4 particles and their distribution have been shown to affect significantly the proton conductivity and mechanical properties of the membranes. The thin-film composite systems were produced by various methods of the obtaining salt particles, their mixing and applying to a polymer matrix. The uniform distribution of particles in the polymer systems with the size of ~300 nm was achieved by a pretreatment of the suspension in a bead mill. CsH2PO4-based mechanically strong membranes with the thickness ~50–100 μm were obtained for the soluble fluoropolymers (F2M, F42, SKF26). With an increase in the mass fraction of the polymer the ability of the membranes to resist the plastic deformation and the mechanical strength increases and comparable to the best low temperature membranes. The proton-conducting membranes (1-x)CsH2PO4 – x fluoropolymer with the optimal combination of the conductivity, mechanical and hydrophobic properties are promising for use in solid acid fuel cells.
Targeting Plasmodium falciparum Invasion via Antibodies Against Merozoite Surface Enolase That Binds to Band 3 of Human Red Blood Cells
Authors: Verma Reena , Balaj Chinthapalli i , SAHAL DINKAR , Sharma Shobhona , Jarori Gotam K.
Published: May 2023

The antibodies targeting invasive proteins of Plasmodium falciparum (Pf) merozoites is a clever strategy against malaria parasite. The recent finding that Plasmodium merozoites surface enolase is a target for growth neutralizing antibodies has generated interest in identifying its re-ceptor (s) on erythrocytes. In the present study, several biochemical experiments were undertaken involving recombinant Pf enolase and antibody against it to search for its cognate receptor. The binding of rPfeno to erythrocytes was selectively sensitive to trypsin but resistant to neuramini-dase. Failure of yeast enolase binding to human red blood cells under similar conditions indicat-ed high specificity of parasite Pfeno. The mass spectrometric and immunological analyses of pro-teins obtained in pull downs and co-immunoprecipitation samples led to identification of band 3 as an interactor/receptor for Plasmodium enolase. Structural characterization of sequences of band 3 - rPfeno interacting regions revealed C-terminal exocytic regions of band 3 to be binding to Pfeno. Similarly, band 3 binding regions of rPfeno were also identified. Identification of receptor-ligand (band 3: Pfeno) pair paves the way for antimalarial anti-Pf enolase-based vaccine, anti-Pf enolase antibodies as drug and also for developing novel small molecule-based invasion inhibi-tory therapeutics including peptidomimetics that could disrupt the band 3: Pfeno protein-protein interactions.
Small Values and Chung's Laws of the Iterated Logarithm for Spatial Surface of Operator Fractional Brownian Motion
Authors: Wang Wensheng
Published: May 2023

The multivariate Gaussian random fields with matrix-based scaling laws are widely used for inference in statistics and many applied

areas. In such contexts interests are often in symmetry and in the rates of change of spatial surfaces in any given direction. This article analyzes the almost sure sample function behavior for operator fractional Brownian motion, including multivariate fractional Brownian motion. We obtain the estimations of small ball probability and the strongly locally nondeterministic for operator fractional Brownian motion in any given direction. Applying these estimates we obtain Chung's laws of the iterated logarithm for spatial surfaces of operator fractional Brownian motion. Our results show that the precise rates of change of spatial surfaces are completely determined by the self-similarity exponent.
Determination of Electronic Loss in Cu(In,Ga)Se2 Solar Cell by Spectroscopic Ellipsometry Analysis and External Quantum Efficiency Simulation
Authors: Sapkota Dhurba R. , Alkhayat Rabee B.
Published: May 2023

Copper indium gallium diselenide, Cu(In,Ga)Se2, thin-film of about 1.2 μm has been deposited on Mo coated soda lime glass by thermal co-evaporation of Cu, In, Ga, and Se sources. The thin film CIGS was characterized by energy dispersive spectroscopy (EDS) and identified the elemental composition of Cu, In, Ga and Se in the film. A CIGS device was completed by the successive deposition of multiple layers; SLG/Mo/CIGS/CdS/ZnO/ITO which yielded the efficiency of 11%. External spectroscopic ellipsometry (ex-situ SE) was performed on the completed device and the device analysis was performed. Starting with the parameterized complex dielectric functions of the individual component layers, SE analysis was performed using a step-wise procedure that ranks the fitting parameters according to their ability to reduce the mean square error (MSE) of the fit. The resulting layer thicknesses and dielectric functions were used to simulate the external quantum efficiency (EQE) of the device assuming complete active layer collection. Electronic losses were identified by comparison of simulated EQE with the measured EQE. The ultimate goal of this work is the optimization of narrow band-gap CIGS-related solar cells for the bottom layer in tandem devices.
A Combinatorial TIR1-Aux/IAA Co-Receptor System for Peach Fruit Softening
Authors: Zhao Yutong , Wang Qin , Guan Dan , Yang Haiqing , Wu Jianwei , Liu Yueping
Published: May 2023

Fruit softening is an important characteristic of peach fruit ripening. The auxin receptor TIR1 (Transport Inhibitor Response 1) plays an important role in plant growth and fruit maturation, but little research has been conducted on the relation of TIR1 to the softening of peach fruits. In this study, the hardness of isolated peach fruits was reduced under exogenous NAA treatment of low concentration, at the same time, the low concentration of NAA treatment reduced the transcription level of PpPG and Ppβ-GAL genes related to cell wall softening, and PpACS1 genes related to ethylene synthesis. The transient over-expression of the PpTIR1 gene in peach fruit blocks caused significant down-regulation of the expression of early auxin-responsive genes, ethylene synthesis and cell wall metabolic genes related to fruit firmness. Through yeast two-hybrid technology, bimolecular fluorescence complementary technology, and firefly luciferase complementation imaging assay, an interaction between PpTIR1 and PpIAA1/3/5/9/27 proteins was revealed, and the interaction depended on auxin and its type and concentration. These results show that PpTIR1-Aux/IAA module has a possible regulatory effect on fruit ripening and softening.
Reconstruction of shrimp catches in Brazil based on generalized linear models
Authors: Silva Matheus Lourenço Soares , Andrade Humber Agrelli
Published: May 2023

Catch data comprises important information for assessing the status of several fisheries. However, it is not always available. A modeling approach using generalized linear models was performed to rebuild catch data supported by environmental variables. Catch information was provided by fisheries’ statistical bulletins about pink (Farfantepenaeus subtilis, F. brasiliensis, and F. paulensis), white (Litopenaeus schmitti), and seabob shrimp (Xiphopenaeus kroyeri). Sea surface temperature and rainfall information were collected from open-access databases by meteorological agencies. Due to low species discrimination over time, a general shrimp catch category was added to the models to help disaggregate quantities for each species. The general category was the most relevant variable, whereas temperature indices showed reduction patterns in catches over time, which may indicate the likely effects of temperature increase on shrimp fisheries. Beyond that, extreme peaks and falls testedthrough residual analysis indicate low reliability mainly in the 1970s and ’80s reports. Information gain varied according to the discrimination ability. States that took longer to discriminate the species presented predictions far from the reports, so the information gains were greater than 100%. Accordingly, reconstructions can be an alternative to restore outdated or missing information and help judge the reliability of official data.
Abū al-Qāsim al-Zajjājī dan Proses Selection-Choice dalam Membangun Argumen Naḥwu: Kajian Uṣūl al-Naḥwi
Authors: Lutfi Mukhammad
Published: May 2023

This research focuses on the thought of Abū al-Qāsim al-Zajjājī and his contributions in naḥwu. By using descriptive qualitative approach, it was found that al-Zajjājī, who lived in the third and fourth centuries of the Hijriyah in Baghdad, with the style “khalaṭa al-madhabayn” tradition, compromised the Basrah and Kufah schools, in other terms, selection (ikhtiyār) and choice (intikhāb) opinions his predecessors. Such traditions have a strong contribution in influencing how al-Zajjājī studied and argued. Through selection and choice, al-Zajjājī proves that it is okay to take opinions from any circles, even through selection and choice it can help explain language phenomena as an introduction to classifying them into special discussions and things similar to them with the aim of expressing the language system with not fanatical to any one sect. The history above also plays a role in having a positive impact towards the maturity of naḥwu studies in subsequent generations, namely the Andalusian naḥwu network with all its past opinions then formulates or applies principles to naḥwu which are more mature and established.
Sosyal Baskınlık Yönelimi, Tehdit Algısı, Gruplararası Temas ve Zenofobik Tutumların Siyasal Eğilim, Etnik ve Dini Kimlikler ile İlişkisi
Authors: SARIDAĞ Sumeyra , ESER Hamza Bahadır
Published: May 2023

Çalışmada, İzmir Konak ilçesinde yaşayan Türkiye Cumhuriyeti vatandaşlarının, geçici koruma statüsündeki Suriyelilere yönelik tutumlarının incelenmesi amaçlanmıştır. Bu doğrultuda, katılımcıların politik eğilimleri, dini ve etnik kimlikleri açısından Suriyelilere yönelik zenofobik tutumları, tehdit algıları, dış grupla kurmuş oldukları temas ve sosyal baskınlık yönelimleri arasında anlamlı bir farklılık olup olmadığı çalışmada irdelenmiştir. Çalışmada Türkçe geçerlik-güvenilirlik ön çalışmaları yapılmış olan zenofobi ölçeği, sosyal baskınlık yönelimi ölçeği, bütünleşik tehdit ölçeği ve sosyal temas ölçeği kullanılmıştır. Doğrulayıcı faktör analizi ve devamında yapılan t testi neticesinde, katılımcılardan Millet İttifakına oy verenlerin zenofobik tutumlarının, sosyal baskınlık-baskınlık yönelimleri ve kültürel tehdit algılarının Cumhur İttifakına oy veren gruba nazaran daha güçlü olduğu görülmüştür. Katılımcılardan Millet İttifakına oy veren grubun temas sıklıklarının ise, Cumhur İttifakına oy veren gruba nazaran daha düşük olduğu görülmüştür. Katılımcılardan etnik kimliğini Türk olarak ifade eden grubun zenofobik tutumları, sosyal baskınlık-baskınlık yönelimleri ile kültürel tehdit algılarının etnik kimliğini Kürt olarak ifade eden gruba nazaran daha güçlü olduğu görülmüştür. Ayrıca katılımcılardan etnik kimliğini Türk olarak ifade eden grubun temas sıklıklarının, etnik kimliğini Kürt olarak ifade eden gruba nazaran daha düşük olduğu görülmüştür. Katılımcıların dini kimlik tercihleri bağlamında zenofobik tutumları, tehdit algıları, dış grupla kurmuş oldukları sosyal temas ve sosyal baskınlık yönelimleri arasında ise anlamlı bir farklılık tespit edilmemiştir.
Sağlık Okuryazarlığının Sağlık İletişimi Sorunlarına Etkisi: Manisa İli İçin Değerlendirme
Authors: GÜL Nazlı , AKMAN DÖMBEKCİ Hilal
Published: May 2023

Sağlık okuryazarlığı kavramı; bireyin sağlık enformasyonlarını okuma, anlama ve bunları sağlığını geliştirme yönünde kullanma olarak karşımıza çıkmaktadır. Bu okuryazarlığı yüksek düzeyde edinen bireyler sağlık iletişimine yönelik sorunların üstesinden gelebilmektedir. Bu çalışmada Manisa’da ikamet eden kişilerin sağlık okuryazarlık düzeylerini belirlemeyi ve sağlık okuryazarlığın sağlık iletişimi sorunlarına etkisini ortaya koymayı hedeflemektedir. Araştırmanın örneklem hacmi 384 bireyden oluştuğu tespit edilmiş olup araştırmaya toplamda 586 birey dahil edilmiştir. Araştırmada sağlık okuryazarlığı ve alt boyutlarıyla demografik değişkenler arasında farklılığın olup olmadığı, sağlık iletişimi sorunları ve alt boyutlarıyla demografik değişkenler arasında farklılığın olup olmadığı ve sağlık okuryazarlığının sağlık iletişimi sorunlarına etkisinin olup olmadığı tespit edilmek istenmiştir. Veriler anket tekniği kullanılarak toplanmış olup SPSS 25 paket programından yararlanılarak analiz edilmiştir. Verilerin analizi için tanımlayıcı istatistiklerden, t testinden, ANOVA testinden ve regresyon analizinden faydalanılmıştır. Araştırma sonucunda Sağlık okuryazarlığı ölçeği ile sağlık iletişimi sorunları ölçeği arasında yapılan regresyon analizinde istatistiki açıdan anlamlılık tespit edilmiştir (p<0,05). Yapılan analize göre Sağlık İletişimi Sorunlarında meydana gelen değişimin %0,8’i Sağlık Okuryazarlığı ölçeği tarafından açıklanmaktadır (R2=0,008). Sağlık Okuryazarlığı ölçeğinde meydana gelen artış Sağlık İletişimi Sorunlarına yansımaktadır (B=0,11).
Validation of a Newly Diagnosis Model of Dynamical Electromyography Network for Neuromuscular Tracing in Hemiplegic Ankle-Foot Motor Dysfunctions
Authors: Xu Ying , Geng Canru , Li Jinping , Guan Juntao , Tang Tong , Hou Ying , Guo Aisong
Published: May 2023

Background: The rating scales cannot locate and quantitatively identify muscles responsible for ankle-foot motor dysfunctions in hemiplegia patients.
Object: To trace calf muscles responsible for neuromuscular dysfunction in hemiplegia patients, using a newly designed diagnosis model of dynamical surface electromyography (sEMG) network.
Methods: Observe the characteristics of eight groups of muscles in bilateral calves in 14 male patients with hemiplegia and 10 age- and sex-matched healthy adults in static standing position, with two linear indices, root mean square (RMS) and median frequency (MF), and five nonlinear network indices, average interlayer mutual information (I), average edge overlap (ω), clustering coefficient (C), average shortest path length (L), and degree centrality (DC).
Results: The RMS of the anterior tibialis (AT), medial gastrocnemius (MG), soleus (SOL) on the affected sides was lower than those on the other sides (P<.05). The MF of the extensor digitorum longus (EDL) on the affected sides was significantly lower than that of the unaffected sides and control groups (P<.05).I, W, and C of the unaffected side were significantly higher than those of the affected sides and the control group, whereas L was lower (P<.05). Compared to the control group, the DC of the AT and EDL on the unaffected sides were higher (P < .05), and that of the MG on the affected sides was lower (P<.05).
Conclusion: In this study, the affected EDL was diagnosed as a passive eccentric muscle, and the gastrocnemius and FDL were prone to paralysis, and in which the FDL was accompanied by hyperresponsiveness. The diagnosis of pathological muscles conditions was accordance with characteristics of muscle conditions of ankle-foot motor dysfunctions in hemiplegia patients. Therefore, the newly designed diagnosis system may locate and quantitatively identify muscles responsible for hemiplegia patients, and the targeted treatments for these muscles might be carried out accurately.
Clinical trial registration number: ChiCTR2100055090.
Simulation and Parametric Optimization of Controller for Three-Link Robotic Manipulator in Casting
Authors: Jangid Mahendra Kumar , Kumar Sunil , Singh Jagtar , Abualigah Laith
Published: May 2023

In this study, a simulation of a three-link robotic manipulator has been analyzed for pouring liquid metal during casting. The robotic manipulator is controlled by a proportional integral derivative (PID) controller, a tilt integral derivative (TID) controller, and a fractional-order proportional integral derivative (FOPID) controller. The controller parameters are optimized by a novel meta-heuristic nature-inspired optimization algorithm called grey wolf optimization (GWO), and a comparative analysis is performed with particle swarm optimization (PSO). This robotic manipulator has been designed in SolidWorks and simulated in MATLAB Simulink/sim-mechanics environment. The end-effector trajectory during the casting and comparative joint trajectory has been studied. The FOPID controller optimized by GWO shows better results by giving less integral time absolute error (ITAE) compared with FOPID-PSO and other controllers. Numerically GWO decreases the error by 3.85%, 9.09%, and 41.89% using PID, TID, and FOPID controller respectively as compared to PSO.
Evolved bacterial siderophore-mediated antibiotic cross-protection
Authors: Jorth Peter , Galdino Anna Clara , Vaillancourt Mylene , Celedonio Diana , Huse Kara , Doi Yohei , Lee Janet
Published: May 2023

Antibiotic cross-protection enables resistant bacteria to protect other bacteria that would be otherwise susceptible to the drug. Cefiderocol is the first siderophore cephalosporin antibiotic approved for treating Gram-negative bacterial infections, including carbapenem-resistant Pseudomonas aeruginosa strains. While highly effective, CFDC resistance has been detected clinically, and mechanisms of resistance and cross-protection are not completely understood. In this study, we used experimental evolution and whole genome sequencing to identify cefiderocol resistance mechanisms and evaluated the trade-offs of evolving resistance. We found some cefiderocol-resistant populations evolved cross-protective social behavior, preventing cefiderocol killing of susceptible siblings. Notably, cross-protection was driven by increased secretion of bacterial iron-binding siderophores, which is unique from previously described antibiotic degradation mediated cross-protection. While concerning, we also showed that resistance can be selected against in drug-free environments. Deciphering the costs associated with antibiotic resistance might aid the development of evolution-informed therapeutic approaches to delay the evolution of antibiotic resistance.
Mitochondrial double-stranded RNAs activates PKR to promote nucleus pulposus pyroptosis and intervertebral disc degeneration during metabolic stress
Authors: Guo Wei , Mu Kun , Li Wen-Shuai , Gao Shun-Xing , linfeng wang , Zhao Jian-Yong , Li Xiao-Ming
Published: May 2023

Intervertebral disc (IVD) degeneration is a common concomitant disease in obesity patients, but the mechanism remains largely unknown. Obsity is a metabolic syndrome that results in the concentrations of circulating lipids increased and metabolic stress. Therefore, pathways that integrate metabolic stress and nucleus pulposus (NP) cell death are of especially important in exploring the mechanisms of IVD degeneration. Here we present evidence that double-stranded RNA-dependent protein kinase (PKR) activates inflammasome and NP cell pyroptosis by sensing mt-dsRNA signals released by mitochondrial damage under metabolic stress, thus promoting the occurrence of IVD degeneration. And PKR deficiency alleviates IVD degeneration caused by metabolic stress in mice. Moreover, metformin prevents PKR activation and protects NP cells partly by attenuating mitochondria damage from metabolic stress. This research presents a comprehensive understanding of innate immune activation mediate by mt-dsRNA-PKR axis in NP cells that underlie the development of IVD degeneration during metabolic stress and recommends metformin as a therapeutic drug for treating IVD degeneration.