bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical Learning Disorder in School-Age Children with Attention-Deficit Hyperactivity Disorder
Authors: Capano Lucia , Minden Debbie , Chen Shirley X , Schachar Russell J , Ickowicz Abel
Published: July 2017

Objectives:

To explore the prevalence of mathematics disorder (MD) relative to reading disorders (RD) in school-age children with attention-deficit hyperactivity disorder (ADHD) and examine the effects of age, sex, cooccurring conduct disorder (CD), and ADHD subtype on this comorbidity.

Methods:

Participants were school-age children ( n = 476) with confirmed DSM-IV diagnosis of ADHD. The assessment included semistructured parent and teacher interviews and standardized measures of intelligence, academic attainment, and language abilities. Based on the presence or absence of concurrent learning disorders, we compared the emerging 4 groups: ADHD-only, ADHD + MD, ADHD + RD, and ADHD + MD + RD.

Results:

Overall prevalence of comorbid ADHD + MD was 18.1%. Age, sex, ADHD subtypes, or comorbid CD did not affect the frequency of MD. Children with concurrent ADHD and either MD or RD attained lower IQ, language, and academic scores than those with ADHD alone. Children with ADHD + MD + RD were more seriously impaired and demonstrated distinct deficits in receptive and expressive language.

Conclusion:

MDs are relatively common in school-age children with ADHD and are frequently associated with RDs. Children with ADHD + MD + RD are more severely impaired. These deficits simply cannot be explained as consequences of ADHD and might have unique biological underpinnings, with implications for diagnostic classification and therapeutic interventions.
Early Predictors of Suicidal Ideation in Young Adults
Authors: Dugas Erika , Low Nancy C P , Rodriguez Daniel , Burrows Stephanie , Contreras Gisèle , Chaiton Michael , O'Loughlin Jennifer
Published: July 2017

Objective:

To identify early predictors of suicidal ideation in young adults, and to determine when specific time-varying determinants become important in predicting later suicidal ideation.

Methods:

Data were available for 877 participants in the Nicotine Dependence in Teens study, an ongoing prospective cohort of students aged 12 to 13 years at cohort inception in 1999. Time-invariant covariates included age, sex, mother's education, language, and self-esteem. Time-varying covariates included depression symptoms, family stress, other stress, alcohol use, cigarette use, and team sports. Independent predictors of past-year suicidal ideation at age 20 years were identified in 5 multivariable logistic regression analyses, one for each of grades 7, 8, 9, 10, and 11.

Results:

Eight per cent of participants (mean age 20.4 years [SD 0.7]; 46% male) reported suicidal ideation in the past year. In grade 7, none of the potential predictor variables were statistically significantly associated with suicidal ideation. In grade 8, participation in sports teams in and (or) outside of school protected against suicidal ideation (OR 0.6; 95% CI 0.4 to 0.8; P = 0.002). Depression symptoms in grades 9, 10, and 11 were independent predictors of suicidal ideation (OR 2.2; 95% CI 1.5 to 3.2, OR 1.6; 95% CI 1.0 to 2.5, and OR 1.9; 95% CI 1.1 to 3.4, respectively). No other variables were statistically significant in the multivariate models.

Conclusion:

Depression symptoms as early as in grade 9 predict suicidal ideation in early adulthood. It is possible that early detection and treatment of depression symptoms are warranted as part of suicide prevention programs.
Beyond the Guidelines for Bipolar Disorder: Practical Issues in Long-Term Treatment with Lithium
Authors: Calkin Cynthia , Alda Martin
Published: July 2017

Objective:

Several treatment guidelines are available for clinicians working with patients with bipolar disorder (BD), but some of the more nuanced aspects of lithium therapy go beyond the scope of such guidelines. Therefore, in this perspective, our objective was to focus on specific practical issues of lithium treatment, including the selection and initiation of long-term treatment, and management and discontinuation (if indicated) of lithium prophylaxis.

Method:

We conducted a focused review of the relevant literature on the treatment of BD.

Results:

Consultation requests to a BD specialty service often relate to issues for which there is limited evidence, including when to initiate long-term treatment, whether choice of mood stabilizer is specific, how long to treat acute episodes, whether to switch or add on medication when treatment fails, how long to continue effective treatment, and what medication to use when a lithium-responsive patient must discontinue lithium.

Conclusion:

Optimal long-term treatment of BD will require more research as well as better alignment of clinical and training programs.

Méthode:

Nous avons mené une revue ciblée de la littérature pertinente sur le traitement du TB.

Résultats:

Les demandes de consultation à un service spécialisé en TB ont souvent trait aux questions pour lesquelles les données probantes sont limitées, notamment, le moment d'initier un traitement à long terme, si le choix d'un régulateur de l'humeur est spécifque, combien de temps traiter les épisodes aigus, s'il faut changer de médicament ou en ajouter lorsque le traitement échoue, combien de temps continuer un traitement efficace, et quel médicament utiliser quand un patient qui répond bien au lithium doit arrêter le lithium.

Conclusion:

Le traitement à long terme optimal du TB exigera plus de recherche ainsi qu'une meilleure harmonisation des programmes cliniques et de formation.
Depression Screening in Primary Care: Why the Canadian Task Force on Preventive Health Care Did the Right Thing
Authors: Thombs Brett D , Ziegelstein Roy C
Published: July 2017

Objective:

To review the recent recommendation against routinely screening adults for depression in primary care settings by the Canadian Task Force on Preventive Health Care (CTFPHC).

Methods:

We reviewed the CTFPHC recommendation and discussed it in the context of relevant evidence.

Results:

Depression screening, which involves using depression symptom questionnaires to attempt to identify patients who have unrecognized depression, was previously recommended by the CTFPHC in primary care settings with staff-assisted depression care programs in place to ensure accurate diagnosis, effective treatment, and follow-up, but not in the absence of such programs. The CTFPHC recently updated this guideline and recommended against routinely screening adults for depression in primary care because there have not been any randomized controlled trials (RCTs) that have shown depression screening to be beneficial and because of a concern about the potentially high number of false-positive screens that would occur. Without evidence from RCTs of better health outcomes from screening, there are numerous factors that suggest that depression screening, even with collaborative depression care, may not be beneficial for patients, including the high rate of patients already treated, uncertainty about the ability of depression screening tools to accurately identify previously unrecognized patients, and relatively small treatment effects among patients with less severe depression who would be most likely to be identified through screening. Routine screening would expose some patients to avoidable risks and would pose a significant cost burden.

Conclusion:

The CTFPHC recommendation to not screen for depression in primary care is consistent with available evidence. Clinicians in primary care settings should be alert to signs of depression and attend to symptoms through assessment and, as appropriate, referral or management, as recommended by the CTFPHC.
Cognition, Function, and Disability in Patients with Schizophrenia: A Review of Longitudinal Studies
Authors: Rajji Tarek K , Miranda Dielle , Mulsant Benoit H
Published: July 2017

This paper aims to review longitudinal studies assessing the impact of cognition on function in patients with schizophrenia. PubMed and Scholars Portal were searched using search terms related to schizophrenia, cognition, function, and longitudinal studies. Some functional abilities have been studied more than others. Some studies suggest that the impact of cognition on function depends on the severity of baseline cognitive deficits. Other studies suggest that the impact of cognition on function depend on what phase of the illness the patient is in or what stage in that particular function the patient is involved in. Finally, few studies assessed interactions between cognition and other aspects of schizophrenia in predicting function, such as functional capacity, insight, motivation, and negative symptoms. More longitudinal and comprehensive studies are needed. A focus on community living is of high public significance as patients with schizophrenia continue to grow old. Future studies should also focus on the longitudinal interactions between cognition and other dimensions of schizophrenia as well as on the biological factors that underlie these interactions.
Long-Term Trend in Pediatric Antidepressant Use, 1983–2007: A Population-Based Study
Authors: Meng Xiangfei , D'Arcy Carl , Tempier Raymond
Published: July 2017

Objective:

Research is needed to clarify and improve our understanding of appropriateness and safety issues concerning antidepressant (AD) treatment. We explored the long-term trend in the dispensing of pediatric ADs using provincial, population-based data from Canada.

Methods:

Data covering 22 ADs were drawn from the Saskatchewan Ministry of Health administrative data files in outpatient settings. The data were for 9 triennial years from 1983 to 2007, a 24-year period, for those aged 0 to 19 in the general population. Descriptive analyses were used.

Results:

In 1983, 5.9 per 1000 population aged 0 to 19 were dispensed at least 1 AD; this decreased to 5.1 per 1000 population in 1989, and then increased to 15.4 per 1000 population in 2007, with a slower increase after 2004. Both sexes were dispensed more ADs from 1989 onwards, with females being the heavier users. The rate of AD use increased significantly with age, and this trend became more pronounced after 1998. Family physicians were the major prescribers and their prescriptions significantly increased from 1989 to 2004 and decreased in 2007. The use of selective serotonin reuptake inhibitors (SSRIs) was the major reason for the increase. The number of AD scripts per patient also increased.

Conclusions:

The growth in the prevalence of AD use among children and youth was largely caused by the use of SSRIs. The possibility of safety issues induced by AD use among children and adolescents, and different patterns of medication practice, suggest continuing education is warranted.
Electroencephalographic Abnormalities and 5-Year Outcome in First-Episode Psychosis
Authors: Manchanda Rahul , Norman Ross , Malla Ashok , Harricharan Rajendra , Northcott Sandra , Richard Julie
Published: July 2017

Objective:

To examine the relation of electroencephalographic abnormalities to 5-year outcomes in first-episode psychosis (FEP).

Methods:

Patients ( n = 103) had their baseline electroencephalogram (EEG) classified by modified Mayo Clinic criteria. Symptoms and psychosocial functioning were rated after 5 years of treatment.

Results:

Dysrhythmic EEG was associated with persistence in positive and negative symptoms of psychoses and poorer psychosocial functioning at 5-year follow-up, independently of other characteristics, such as duration of untreated illness or premorbid adjustment. A higher percentage of people with comorbid substance use disorder had normal EEG.

Conclusions:

Abnormal baseline EEG in FEP is associated with poorer 5-year symptomatic and functional outcome.
Are the Effects of Duration of Untreated Psychosis Socially Mediated?
Authors: Norman Ross M G
Published: July 2017

Investigation of possible mechanisms by which longer duration of untreated psychosis (DUP) could influence treatment outcomes has focused primarily on evidence for neurotoxic effects. It is also possible that longer DUP has psychosocial effects, which could mediate its impact on outcomes. The evidence of relevance to such socially toxic effects is reviewed, with particular reference to the possible role of social support. There is no definite evidence for social support as a mediator of the influence of DUP, but further investigation of this issue is warranted.
Factors Associated With Care Workers’ Intention to Leave Employment in Nursing Homes: A Secondary Data Analysis of the Swiss Nursing Homes Human Resources Project
Authors: Gaudenz Clergia , De Geest Sabina , Schwendimann René , Zúñiga Franziska
Published: July 2017

The emerging care personnel shortage in Swiss nursing homes is aggravated by high turnover rates. As intention to leave is a predictor of turnover, awareness of its associated factors is essential. This study applied a secondary data analysis to evaluate the prevalence and variability of 3,984 nursing home care workers’ intention to leave. Work environment factors and care worker outcomes were tested via multiple regression analysis. Although 56% of care workers reported intention to leave, prevalences varied widely between facilities. Overall, intention to leave showed strong inverse relationships with supportive leadership and affective organizational commitment and weaker positive relationships with stress due to workload, emotional exhaustion, and care worker health problems. The strong direct relationship of nursing home care workers’ intention to leave with affective organizational commitment and perceptions of leadership quality suggest that multilevel interventions to improve these factors might reduce intention to leave.
Nutrition Screening vs Nutrition Assessment: What’s the Difference?
Authors: Correia Maria Isabel Toulson Davisson
Published: July 2017

Screening and assessment imply different processes, with the former indicating risk factors for a deprived nutrition condition and the latter providing the nutrition diagnosis. Both should be routinely performed at hospital admission according to recommended guidelines; however, this is not the reality worldwide, and undernutrition remains highly prevalent in the hospital setting. Therefore, the objective of the current review is to delve into the principles leading to nutrition status deficiencies and how they should be addressed by screening and assessment. A critical appraisal for the reasons associated with the misunderstanding between screening and assessing is proposed without further discussing the many available screening tools while approaching some of the assessment instruments.
Development of a membrane of poly (L-co-D,L lactic acid-co-trimethylene carbonate) with aloe vera: An alternative biomaterial designed to improve skin healing
Authors: Komatsu Daniel , Mistura Daniel V , Motta Adriana , Domingues Juliana A , Hausen Moema A , Duek Eliana
Published: July 2017

The search for new therapies and drugs that act as topical agents to relieve pain and control the infectious processes in burns always attracted interest in clinical trials. As an alternative to synthetic drugs, the use of natural extracts is useful in the development of new strategies and formulations for improving the life quality. The aim of this study was to develop a wound dressing using Poly(L-co-D,L lactic acid-co-TMC) (PLDLA-co-TMC) containing aloe vera (AV). This natural plant extract is known for its modulatory effects under healing process. The membrane of PLDLA-co-TMC+aloe vera was prepared at different concentrations of AV (5, 10, 15 and 50%). The FTIR showed no change in the PLDLA-co-TMC spectrum after AV addition, while the swelling test showed changes only in PLDLA-co-TMC+AV at 50%. The wettability measurements showed decrease in the contact angle in all samples after the AV addition in the polymer, while the AV release test showed that PLDLA-co-TMC+50%AV sample has higher AV release rate than the sample with other AV concentrations. The SEM analysis showed that AV was homogeneously distributed at 5% only. Tensile tests demonstrated an increase in the Young's modulus and a reduction in the elongation till rupture of the PLDLA-co-TMC after the addition of AV. Biocompatibility in vitro evaluation with fibroblast cells seeded in the membranes of PLDLA-co-TMC+AV showed that the cells were able to adhere, proliferate and maintain mitochondrial activity in all AV concentrations tested. Due to the known skin medicinal properties attributed to AV and the results here obtained, we suggest that after in vivo trials, the PLDLA-co-TMC+AV should be a promising biomaterial for application as a device for skin curative and healing agent.
Investigation of the micropolar lubricant and thermal effects in the slot entry hybrid journal bearings
Authors: Khatak Pankaj , Garg HC
Published: July 2017

The present article studies the combined influence of the micropolar lubricant and thermal effects in the slot entry hybrid journal bearings. Bearing performance characteristics are computed by the concurrent solution of modified Reynolds, three-dimensional micropolar energy, and three-dimensional conduction equations. Thermohydrostatic characteristics of the slot entry hybrid journal bearings have been studied vis-à-vis isothermal characteristics. The results obtained numerically indicate that isoviscous assumption of the lubricant is incorrect and the bearing performance is significantly affected by the increase in temperature. Hence, it is essential to consider the thermal effects for the bearings operating with the micropolar lubricant for reliable performance analysis of the bearings.
Health and water quality benefits of alternative sewerage systems in Metro Manila, Philippines
Authors: Palanca-Tan Rosalina
Published: July 2017

This paper presents results of a household survey on the current sanitation and sewerage conditions in Metro Manila. The survey included a choice, measured in terms of the marginal willingness to pay (MWTP), between two alternative domestic wastewater treatment systems: 1) a sewerage system connecting individual households to a treatment plant through sewer lines; and 2) a combined drainage–sewerage system in which wastewater effluent flows with rainwater through flood canals and is intercepted for treatment only at a certain point in the waterway. With the second, the health improvement effect may be limited, but the cost can be significantly lower. The finding in favour of the combined drainage–sewerage system lends some support to this new approach in municipal wastewater treatment, which some other increasingly congested metropolises in Asian countries are likewise adopting, as an alternative to the more costly individual household sewer connections.
Resisting Temptation: Tracking How Self-Control Conflicts Are Successfully Resolved in Real Time
Authors: Stillman Paul E. , Medvedev Danila , Ferguson Melissa J.
Published: July 2017

Across four studies, we used mouse tracking to identify the dynamic, on-line cognitive processes that underlie successful self-control decisions. First, we showed that individuals display real-time conflict when choosing options consistent with their long-term goal over short-term temptations. Second, we found that individuals who are more successful at self-control—whether measured or manipulated—show significantly less real-time conflict in only self-control-relevant choices. Third, we demonstrated that successful individuals who choose a long-term goal over a short-term temptation display movements that are smooth rather than abrupt, which suggests dynamic rather than stage-based resolution of self-control conflicts. These findings have important implications for contemporary theories of self-control.
For Whom the Mind Wanders, and When, Varies Across Laboratory and Daily-Life Settings
Authors: Kane Michael J. , Gross Georgina M. , Chun Charlotte A. , Smeekens Bridget A. , Meier Matt E. , Silvia Paul J. , Kwapil Thomas R.
Published: July 2017

Undergraduates ( N = 274) participated in a weeklong daily-life experience-sampling study of mind wandering after being assessed in the lab for executive-control abilities (working memory capacity; attention-restraint ability; attention-constraint ability; and propensity for task-unrelated thoughts, or TUTs) and personality traits. Eight times a day, electronic devices prompted subjects to report on their current thoughts and context. Working memory capacity and attention abilities predicted subjects’ TUT rates in the lab, but predicted the frequency of daily-life mind wandering only as a function of subjects’ momentary attempts to concentrate. This pattern replicates prior daily-life findings but conflicts with laboratory findings. Results for personality factors also revealed different associations in the lab and daily life: Only neuroticism predicted TUT rate in the lab, but only openness predicted mind-wandering rate in daily life (both predicted the content of daily-life mind wandering). Cognitive and personality factors also predicted dimensions of everyday thought other than mind wandering, such as subjective judgments of controllability of thought. Mind wandering in people’s daily environments and TUTs during controlled and artificial laboratory tasks have different correlates (and perhaps causes). Thus, mind-wandering theories based solely on lab phenomena may be incomplete.
Efficient body fat estimation using multistage pair ranked set sampling
Authors: Mahdizadeh M , Zamanzade Ehsan
Published: July 2017

Rank-based sampling methods are applicable in settings where precise measurements are expensive, but small sets of units can be accurately ranked at negligible cost. This article introduces one such a design, called multistage pair ranked set sampling. It mitigates ranking burden associated with a competitor scheme, namely multistage ranked set sampling. The mean estimator in multistage pair ranked set sampling is unbiased, and under perfect rankings has variance no larger than its simple random sampling counterpart. Although the suggested mean estimator is outperformed by its multistage ranked set sampling analog in terms of precision under perfect rankings, the situation may be reversed if cost considerations are taken into account. The methodology is illustrated using a medical dataset.
Simulating, marketing, and playing war: US–Jordanian military collaboration and the politics of commercial security
Authors: Schuetze Benjamin
Published: July 2017

The King Abdullah II Special Operations Training Center (KASOTC) was financed and established by the US Department of Defense, is operated by a US private business, and is owned by the Jordanian army. It not only offers a base for the training of international Special Forces and Jordanian border guards, but also for military adventure holidays, corporate leadership programs, and stunt training for actors. This article provides an analysis of the processes and technologies involved in US–Jordanian military collaboration by investigating some of the ways in which war is simulated, marketed, and played at KASOTC. Particular focus is paid to the stark biopolitical judgments about the different worth of human subjects and their role in intersecting processes of militarization and commercialization. The article argues that US–Jordanian military collaboration at KASOTC is marked by the simultaneous blurring and reinforcement of boundaries, as commercial security is moralized and imagined moral hierarchies marketized. While war at KASOTC is an interactive and consumable event for some, it engenders deadly realities for others. The article is an empirically-grounded contribution to critical security studies based on interviews and observations made during a visit to KASOTC in early 2013.
The Singularity of Social Entrepreneurship: Untangling its Uniqueness and Market Function
Authors: Roundy Philip T. , Bonnal Michaël
Published: July 2017

Social entrepreneurship is an activity that is receiving intense scrutiny from scholars, practitioners and policymakers. However, research is only beginning to explore the unique function social entrepreneurs fill in the marketplace. This conceptual article examines if social entrepreneurs indeed represent a novel category of market actor. Building on prior work claiming that the unique function of social entrepreneurs is the creation of positive externalities and generation of spillover benefits for society, we compare social entrepreneurs with conventional entrepreneurs and other entities that seek to increase social welfare, including governments and traditional nonprofit organisations. Specifically, we contend that the strengths of social entrepreneurship are its reliance on voluntary exchange, promotion of dignity and self-sufficiency in beneficiaries, attunement to the signals of the marketplace and ability to tap into consumer spending. We also uncover the limitations of social entrepreneurship, which include the challenge of combining multiple institutional logics, the existence of social issues around which viable businesses cannot be built, dependence on consumer demand and competitive disadvantages relative to conventional businesses. We discuss the implications of our conceptualisation of social entrepreneurship for practitioners, policymakers and future research.
Exposure to Hardship Financing for Healthcare among Rural Poor in Chhattisgarh, India
Authors: John Denny , Kumar Vijender
Published: July 2017

Background:

This article examines the exposure of hardship financing in a cross-section of households in four blocks of Rajnandgaon district in Chhattisgarh state, India. We define hardship financing as having to borrow money with interest or to sell assets to pay out-of-pocket healthcare costs.

Methods:

We used survey data of 4,600 low-income rural households using a three-stage cluster sampling procedure. In first stage, blocks were selected purposively, the second stage involved selection of villages using probability proportional to size (PPS) sampling and lastly, households were randomly selected. Binary logistics regression analysis was used to identify the determinants of exposure to hardship financing related to out-of-pocket expenses for healthcare.

Results:

About 14.9 per cent of the total households were exposed to hardship financing. Hardship financing occurs not only for hospitalization (nearly 10 per cent) but also for outpatient care (7.91 per cent) and maternity (around 10 per cent). Our logistics regression revealed that health expenditure in the last year was positively associated with the risk for hardship financing. Other correlates of hardship financing included education-level of the head of the household, in-house toilet facility and place of residence/blocks.

Conclusion:

Rural households, especially the poorer households, spend higher average healthcare payments and are exposed to hardship financing on health.
HBXIP suppression reduces cell proliferation and migration and its overexpression predicts poor prognosis in non-small-cell lung cancer
Authors: Wang Yixuan , Li Nan , Che Shuanlong , Jin Tiefeng , Piao Junjie , Liu Shuangping , Lin Zhenhua
Published: July 2017

Emerging evidence has demonstrated that the high expression of HBXIP has been correlated with many cancers. With evaluation of the functional role of HBXIP in non-small-cell lung cancer, the primary aim of this study is to investigate the correlation between HBXIP expression and the prognosis of non-small-cell lung cancer patients. The protein levels of HBXIP were detected using western blotting in non-small-cell lung cancer cells. Cell proliferation and migration assays were measured to evaluate the function of HBXIP in non-small-cell lung cancer cells. A total of 120 non-small-cell lung cancer patients with strict follow-up and 60 adjacent non-tumor lung tissues were selected for immunohistochemical staining of the HBXIP protein. The localization of the HBXIP protein was detected in A549 non-small-cell lung cancer cells using immunofluorescence staining. The correlation between HBXIP expression and the clinicopathological features of non-small-cell lung cancer patients was analyzed by a chi-squared and Fisher’s exact test. The overall survival rates of all of the non-small-cell lung cancer patients were calculated using the Kaplan–Meier method, and univariate and multivariate analyses were performed using the Cox proportional hazards regression model. In function, we showed that suppression of HBXIP decreased A549 cell proliferation and migration. HBXIP protein showed a mainly cytoplasmic staining pattern in non-small-cell lung cancer using immunohistochemical staining in paraffin-embedded non-small-cell lung cancer tissues and immunofluorescence staining in A549 cells. The HBXIP protein had strong positive staining in the non-small-cell lung cancer tissues, which was significantly higher than the percentage of adjacent non-tumor tissues. The overexpression of HBXIP was closely correlated with histological grade, clinical stage, lymph node metastasis, and lower overall survival rates of patients with non-small-cell lung cancer. Moreover, multivariate analysis suggested that HBXIP emerged as a significant independent prognostic factor along with clinical stage in patients with non-small-cell lung cancer. In conclusion, a high level of expression of HBXIP is associated with the progression of non-small-cell lung cancer and may be a useful biomarker for poor prognostic evaluation and a potential molecular therapy target for patients with non-small-cell lung cancer.
MiR-143 inhibits cell proliferation and invasion by targeting DNMT3A in gastric cancer
Authors: Zhang Quan , Feng Yong , Liu Ping , Yang Jing
Published: July 2017

Increasing evidence has suggested that MircroRNAs (miRNAs) dysregulated in pathogenesis and tumorigenicity in human cancers including gastric cancer (GC). MiR-143 had been reported to function as tumor suppressor in GC progression, however, the underlying function of miR-143 in GC still need to be well known. In the study, we revealed that miR-143 was significantly down-regulated in GC cell lines. Upregulation of miR-143 inhibited cell proliferation, invasion, S phase cell proportion and cell cycle related protein levels of Cyclin D1, CDK4 and CDK6 in GC. Furthermore, luciferase reporter assays demonstrated that DNMT3A was a direct target of miR-143 and Upregulation of miR-143 inhibited the DNMT3A mRNA and protein expression levels in GC cells. Moreover, we demonstrated that DNMT3A knockdown rescued the promoting effect of miR-143 inhibitor on cell proliferation in GC. Thus, these results demonstrated that miR-143 targeted DNMT3A in GC cells and inhibit GC tumorigenesis and progression, which may provide a novel therapeutic target of GC.
Long non-coding RNA CCAT2 promotes cell proliferation and invasion through regulating Wnt/β-catenin signaling pathway in clear cell renal cell carcinoma
Authors: Huang Jian-lin , Liao Yong , Qiu Ming-xing , Li Jun , An Yu
Published: July 2017

Clear cell renal cell carcinoma (ccRCC) is a common urologic malignancy. Long non-coding RNA colon cancer–associated transcript 2 (CCAT2) has been suggested as serving pivotal roles in tumorigenesis. However, the clinical significance and biological role of CCAT2 in ccRCC remains elusive. The purpose of this study is to identify the function of CCAT2 in ccRCC and its possible molecular mechanism. Expression of CCAT2 was analyzed in 61 ccRCC tissues and two ccRCC cell lines (786-O and ACHN) by quantitative reverse transcription polymerase chain reaction. The functional roles of CCAT2 in ccRCC were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation assay, Transwell assay, and flow cytometric analysis. The influence of CCAT2 on tumorigenesis was monitored by in vivo mice xenograft model. The activation of Wnt/β-catenin signaling pathway was evaluated by the TOP/FOP Wnt luciferase reporter assay and western blot assay. CCAT2 expression was markedly higher in ccRCC cell lines and tissues, being positively associated with tumor size and tumor stage in ccRCC patients. Patients with higher CCAT2 expression had a markedly poorer overall survival than did patients with low CCAT2 expression. Knocking down CCAT2 expression led to reduced cell proliferation and increased apoptosis of ccRCC cells in vitro as well as the activation of Wnt/β-catenin signaling pathway, and CCAT2 overexpression remarkably enhanced these oncogenic properties. In vivo mice xenograft model also showed that knocking CCAT2 expression inhibited the growth of ccRCC xenografts. In conclusion, these results indicated that CCAT2 may play a critical role in ccRCC progression and will be further considered as a biomarker for predicting the survival of ccRCC patients and a potential therapeutic target for ccRCC intervention.
Expression of embryonic stem cell markers in acute myeloid leukemia
Authors: Picot Tiphanie , Aanei Carmen Mariana , Fayard Amandine , Flandrin-Gresta Pascale , Tondeur Sylvie , Gouttenoire Marina , Tavernier-Tardy Emmanuelle , Wattel Eric , Guyotat Denis , Campos Lydia
Published: July 2017

Acute myeloid leukemia is driven by leukemic stem cells which can be identified by cross lineage expression or arrest of differentiation compared to normal hematopoietic stem cells. Self-renewal and lack of differentiation are also features of stem cells and have been associated with the expression of embryonic genes. The aim of our study was to evaluate the expression of embryonic antigens (OCT4, NANOG, SOX2, SSEA1, SSEA3) in hematopoietic stem cell subsets (CD34+CD38− and CD34+CD38+) from normal bone marrows and in samples from acute myeloid leukemia patients. We observed an upregulation of the transcription factors OCT4 and SOX2 in leukemic cells as compared to normal cells. Conversely, SSEA1 protein was downregulated in leukemic cells. The expression of OCT4, SOX2, and SSEA3 was higher in CD34+CD38− than in CD34+CD38+ subsets in leukemic cells. There was no correlation with biological characteristics of the leukemia. We evaluated the prognostic value of marker expression in 69 patients who received an intensive treatment. The rate of complete remission was not influenced by the level of expression of markers. Overall survival was significantly better for patients with high SOX2 levels, which was unexpected because of the inverse correlation with favorable genetic subtypes. These results prompt us to evaluate the potential role of these markers in leukemogenesis and to test their relevance for better leukemic stem cell identification.
Age trends in musical preferences in adulthood: 3. Perceived musical attributes as intrinsic determinants of preferences
Authors: Bonneville-Roussy Arielle , Eerola Tuomas
Published: July 2017

Increased age has been found to be associated with differences in musical preferences in adulthood. In past research, these differences were mostly attributed to changes in the social context. However, these influences were small and a large proportion of variance in age trends in musical preferences still remains to be explained. The aim of this article is to investigate the hypothesis that age trends in musical preferences are related to differences in preferences for some intrinsic attributes of the music in line with the Music Preferences in Adulthood Model (Bonneville-Roussy et al., 2017). Adult participants ( N = 481) were asked to rate their preferences for extracts of 51 audio-music recordings (music clips) and musical attributes related to dynamics, pitch, structure, tempo, and timbre. Audio-features of the 51 clips were extracted using Music Information Retrieval methods. Using self-report, we found that the musical preferences of adults were linked with distinct likings for musical attributes, with large effects. We also discovered that self-rated attributes associated with dynamics and timbre moderated the links between age and musical preferences. Using the extracted features, we found that musical preferences were linked with distinct patterns of musical features. Finally, we established that the patterns of preferences of emerging, young and middle-aged adults were increasingly influenced by audio-features of timbre, dynamics and tonal clarity. These findings suggest that age trends in musical preferences could be partially explained by differences in the ways individuals process the intrinsic attributes of the music with age.
Characteristics and outcomes of patients with drug overdose requiring admission to Intensive Care Unit
Authors: Athavale Vinit , Green Cameron , Lim Kai Zheong , Wong Caroline , Tiruvoipati Ravindranath
Published: July 2017

Objective:

Approximately 20% of patients admitted to hospital with drug overdose will require intensive care unit (ICU) admission. An understanding of the characteristics of these patients may assist with their management and identify those patients at risk of multiple hospital presentations due to drug overdose. Our aim was to examine the characteristics of patients admitted to ICU following drug overdoses and identify the predictors of multiple hospital presentations due to drug overdose.

Methods:

Patients admitted to a metropolitan ICU over a three-year period following drug overdoses were identified using ICU patient databases, and their medical records.

Results:

There were 254 admissions due to drug overdoses. The majority of overdoses were intentional (82.7%) and included multiple agents (68.1%). Two-thirds of patients had psychiatric diagnosis, and 54% had documented history of substance use disorders. In-hospital mortality was 2.8%. Over half of patients admitted had documented history of prior hospital presentation due to overdoses. Personality disorder and schizophrenia were independent predictors of multiple hospital presentations due to overdoses.

Conclusion:

Personality disorders or schizophrenia were independent predictors of patients with multiple overdose presentations. Preventative strategies focusing on these patients may reduce the incidence of their hospital presentations and ICU admissions.
What’s to be done when ‘foul whisp rings are abroad’? Gossip and rumour in health organisations
Authors: O’Connor Nick , Kotze Beth , Storm Victor
Published: July 2017

Objectives:

This article explores the relevance of gossip and rumour to health organisations and presents what limited empirical research is available specific to the management of gossip and rumour in health organisations.

Conclusion:

The concept of a sentinel function for gossip and rumour in health organisations is proposed as a topic worthy of further research.
New Frontiers in Analyzing Dynamic Group Interactions: Bridging Social and Computer Science
Authors: Lehmann-Willenbrock Nale , Hung Hayley , Keyton Joann
Published: July 2017

This special issue on advancing interdisciplinary collaboration between computer scientists and social scientists documents the joint results of the international Lorentz workshop, “Interdisciplinary Insights into Group and Team Dynamics,” which took place in Leiden, The Netherlands, July 2016. An equal number of scholars from social and computer science participated in the workshop and contributed to the papers included in this special issue. In this introduction, we first identify interaction dynamics as the core of group and team models and review how scholars in social and computer science have typically approached behavioral interactions in groups and teams. Next, we identify key challenges for interdisciplinary collaboration between social and computer scientists, and we provide an overview of the different articles in this special issue aimed at addressing these challenges.
Intravenous Vancomycin Associated With the Development of Nephrotoxicity in Patients With Class III Obesity
Authors: Choi Yookyung Christy , Saw Stephen , Soliman Daniel , Bingham Angela L. , Pontiggia Laura , Hunter Krystal , Chuang Linda , Siemianowski Laura A. , Ereshefsky Benjamin , Hollands James M.
Published: July 2017

Background:A consensus statement recommends initial intravenous (IV) vancomycin dosing of 15-20 mg/kg every 8- 24 hours, with an optional 25- to 30-mg/kg loading dose. Although some studies have shown an association between weight and the development of vancomycin-associated nephrotoxicity, results have been inconsistent. Objective: To evaluate the correlation between incidence of nephrotoxicity associated with weight-based IV vancomycin dosing strategies in nonobese and obese patients. Methods: This retrospective cohort study evaluated hospitalized adult patients admitted who received IV vancomycin. Patients were stratified into nonobese (body mass index [BMI] <25 kg/m2), obesity class I and II (BMI 30-39.9kg/m2), and obesity class III (BMI≥40 kg/m2) groups; patients who were overweight but not obese were excluded. Incidence of nephrotoxicity and serum vancomycin trough concentrations were evaluated. Results: Of a total of 62 documented cases of nephrotoxicity (15.1%), 13 (8.7%), 23 (14.3%), and 26 (26.3%) cases were observed in nonobese, obesity class I and II, and obesity class III groups, respectively ( P=0.002). Longer durations of therapy ( P<0.0001), higher initial maintenance doses in both total milligrams/day ( P=0.0137) and milligrams/kilogram ( P=0.0307), and any trough level >20 mg/L ( P<0.0001) were identified as predictors of development of nephrotoxicity. Concomitant administration of piperacillin/tazobactam, diuretics, and IV contrast were associated with development of nephrotoxicity ( P<0.005, all). Patients with class III obesity were 3-times as likely to develop nephrotoxicity when compared with nonobese patients (odds ratio [OR]=2.99; CI=1.12-7.94) and obesity class I and II patients (OR=3.14; CI=1.27-7.75). Conclusions: Obesity and other factors are associated with a higher risk of vancomycin-associated nephrotoxicity.
Career Exploration and Career Decision-Making Difficulties
Authors: Storme Martin , Celik Pinar
Published: July 2017

This article investigated the moderating role of creative self-efficacy (CSE) on the relationship between career exploration and career decision-making difficulties among French undergraduate students ( N = 415). Drawing a parallel between the career decision-making process and the notion of creative problem-solving, we reasoned that career exploration without CSE—that is, the confidence in one’s own ability to solve original and complex problems—can be associated with career decision-making difficulties. Our study shows that among students who have low levels of CSE, environmental exploration, and self-exploration regarding career options are respectively associated with dysfunctional beliefs regarding one’s career path and general indecisiveness. We discuss the implications of the results.
Informed Consent in Dentistry
Authors: Reid Kevin I.
Published: July 2017

A review of literature regarding informed consent in dentistry reveals a paucity of information and minimal scholarship devoted to this subject. But this begs the question about informed consent somehow being different for dentistry than for medicine or other healthcare delivery. My account draws distinctions where appropriate but is rooted in the premise that informed consent is an ethical construct applicable to vulnerable people as patients independent of what type of treatment or body part being considered. This paper highlights the crucial importance of the process of informed consent and refusal in dentistry, underscoring its important place in oral healthcare. This paper will not address the unique circumstances involving consent in those without capacity or focus on informed consent in the research setting; our focus will be on those patients with full decisionmaking capacity in the clinical setting. I will emphasize the importance of disclosure of treatment options and highlight the benefits of shared-decision-making in the informed consent process.
Research Capacity Strengthening in Low- and Middle-Income Countries: Ethical Explorations
Authors: Hyder Adnan A. , Rattani Abbas , Pratt Bridget
Published: July 2017

With developed country governments and high resource institutions engaging in research in low- and middle-income countries (LMIC), we argue that these entities have a moral obligation to help build and strengthen research infrastructure and capacity so local scientists and institutions can adequately conduct studies to understand and resolve the health burdens in low and middle income countries. We explore the moral justifications and motivations behind engaging in research capacity strengthening in the health sector in LMIC at multiple levels. In highlighting these issues, this paper aims to initiate a global discourse around why capacity development in LMIC has a moral basis at the individual, institutional and system levels.
Action, Not Rhetoric, Needed to Reverse the Opioid Overdose Epidemic
Authors: Davis Corey , Green Traci , Beletsky Leo
Published: July 2017

Despite shifts in rhetoric and some positive movement, Americans with the disease of addiction are still often stigmatized, criminalized, and denied access to evidencebased care. Dramatically reducing the number of lives unnecessarily lost to overdose requires an evidence-based, equity-focused, well-funded, and coordinated response. We present in this brief article evidence-based and promising practices for improving and refocusing the response to this simmering public health crisis. Topics covered include improving clinical decision-making, improving access to non-judgmental evidence-based treatment, investing in comprehensive public health approaches to problematic drug use, and changing the way law enforcement actors interact with people who use drugs.
Homelessness and the Public's Health: Legal Responses
Authors: Hodge James G. , DiPietro Barbara , Horton-Newell Amy E.
Published: July 2017

This commentary addresses public health issues underlying homelessness and related law, policy, and advocacy options. After framing public health issues for affected individuals and the community, legal and policy approaches and related barriers are assessed. Major topics include deficits in housing availability, the role of state-based Medicaid programs, criminalization of homelessness, and the use of emergency declarations seeking to address particular issues related to homelessness in select states and localities.
Promoting Mental Health and Well-Being in Public Health Law and Practice
Authors: Krueger Jill , Counts Nathaniel , Riley Brigid
Published: July 2017

This article discusses the relationship between stress, physical health, and well-being in cultural context, offers examples of laws, policies, and programs to promote mental health and well-being, and examines how collective impact supports mental health and well-being.
Finished with Menthol: An Evidence-Based Policy Option That Will Save Lives
Authors: Lester Joelle M. , Gagosian Stacey Younger
Published: July 2017

Smoking remains the leading cause of preventable disease and death in the United States, killing approximately 480,000 people each year. This crushing health burden falls disproportionately, and recent CDC data shows that large disparities in adult cigarette smoking remain. One factor in these disparities is the use of flavors. Menthol cigarettes and other flavored tobacco products are used at higher rates by vulnerable populations including youth and young adults, African Americans, women, Hispanics and Asian Americans. This is no accident; the tobacco industry has long targeted these same groups. Given FDA's failure to act to ban flavored tobacco products, states and municipalities are considering taking matters into their own hands to protect their communities from these dangerous products. The authors will explore state and local authority to restrict the sales of these products and review the evidence base indicating that removing flavored tobacco products – and menthol combustible products in particular - from the market would significantly reduce the toll of illness and death caused by these products.