bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficiency estimation of super-viscous oil recovery by in-situ catalytic upgrading in cyclic steam stimulation: from laboratory screening to numerical simulation
Authors: Usmanov Sergey A. , Usmanov Sergey A. , Minkhanov Ilgiz F. , Simakov Yaroslav O. , Vakhin Alexey V. , Sudakov Vladislav A. , Varfolomeev Mikhail A. , Nurgaliev Danis K.
Published: January 2024

The article provides an overview of ion-modified waterflooding technology, also known as low salinity, controlled salinity, or Smart water. This technology is currently considered one of the most promising approaches in the development of oil deposits in carbonate reservoirs due to its economic efficiency and environmental safety.
The article discusses the main mechanisms and processes underlying ion-modified waterflooding and presents the results of laboratory studies conducted on core samples from foreign oil deposits. It includes an analysis of several studies, including contact angle measurements and core flooding experiments on core samples from oil deposits in carbonate reservoirs on the eastern side of the Melekess depression in the Republic of Tatarstan.
It is important to note that the Vereyian deposits explored in this article are not a typical example of test objects for ion-modified water injection. This is because they are characterized by a low reservoir temperature of 23 °C, which suggests that the efficiency of the technology would likely be lower compared to studies conducted abroad, where reservoir temperatures were significantly higher. For example, Darvish Sarvestani et al. studied reservoir conditions at 90 °C, Yousef et al. – reservoir temperature of 100 °C, and Austad et al. examined the Ekofisk field at 130 °C and the Volhall field at 90 °C in Norway.
However, as several studies have indicated, prolonged contact between rock samples and ion-modified water contributes to significant hydrophilization of the rock surface, as confirmed by contact angle measurements. The contact angle decreases from approximately 138.3° to 53.45° after exposure to ion-modified water.
Additionally, the core flooding experiment demonstrated a slight increase in the oil displacement coefficient, reaching 9.2%.
These findings suggest the potential for enhanced oil recovery by injecting Smart water into the Vereyian sediments, although further research is required to confirm the underlying mechanism.
Evaluation and Treatment of Cognitive Dysfunctions in Schizophrenia and Bipolar Disorder
Authors: EKER Çağdaş
Published: January 2024

Cognitive dysfunction is the most important determinant for the recovery in schizophrenia and bipolar disorder. Cognitive dysfunction serves as an endophenotype although it may be a consequence of drug treatments. In schizophrenia starting from the first episode, pronounced cognitive defects such as cognitive flexibility, inhibition, verbal fluency, verbal memory and visual-motor processing are observable. These cognitive defects remain stable in the chronic phase of schizophrenia. On the other hand, cognitive dysfunctions in bipolar disorder patients have a heterogeneous pattern. One group of patients show no evidence of cognitive dysfunction while one group has limited dysfunction (of processing speed, attention, verbal learning and social cognition) and another one has wide spread dysfunctions as seen in schizophrenia. Despite its importance, no satisfactory results have been achieved in the treatment of cognitive dysfunctions in schizophrenia and bipolar disorder. In this article, the evaluation and treatment of the most frequent cognitive dysfunctions of schizophrenia and bipolar disorder are reviewed.
A Review of Research on the Role of Different Types of Religiosity in Terror Management
Authors: ALPARSLAN Kenan , KUŞDİL M. Ersin
Published: January 2024

This review paper aims to reveal the role of different types of religiosity based on research addressing religiosity in terms of in-group and out-group distinction within the scope of Terror Management Theory (TMT). Studies point out two important results of the phenomenon: the first is the fact that general religiosity focusing on only one aspect of religiosity (religious belongingness, afterlife belief, etc.) to measure religiosity increases worldview defense, supporting the hypothesis of mortality salience. The second is the fact that different religious orientations (intrinsic, fundamentalist, etc.) cause various reactions, depending on their unique characteristics when mortality is salient. In the current study, possible reasons for the differences between research findings are discussed. In order to clarify the roles that different types of religiosity play in terror management, a classification based on the strong-flexible and exclusive-inclusive poles of the “belief” and “belonging” dimensions suggested by Sarouglu has been proposed. It has been argued that religiosity types would function in terror management in different ways, depending on the classification in which they are placed. For example, when the religious worldview is threatened, the strong-exclusive pattern (e.g., religious fundamentalism) can lead to more negative reactions, while the strong-inclusive pattern (e.g., intrinsic religiosity) can be associated with positive processes in inter-group relationships. Future research on this classification and types of religiosity can provide unique contributions to developing TMT. On the other hand, knowing the roles of different forms of religiosity in managing existential concerns may be of therapeutic benefit in coping with death, bereavement, grief and related processes.
НАРУШЕНИЯ ОБМЕНА ЦИНКА И МЕДИ ПРИ САХАРНОМ ДИАБЕТЕ 2-ГО ТИПА (ОБЗОР)
Authors:   ФГБОУ ВО «Оренбургский государственный университет», Институт биоэлементологии, Нотова С.В. , Кияева Е.В. ,   ФГБОУ ВО «Оренбургский государственный университет», Институт биоэлементологии, Казакова Т.В. ,   ФГБОУ ВО «Оренбургский государственный университет», Институт биоэлементологии, Маршинская О.В. ,   ФГБОУ ВО «Оренбургский государственный университет», Институт биоэлементологии, Поляница Д.В. ,   АНО «Центр биотической медицины»
Published: January 2024

Сахарный диабет 2-го типа и сопутствующие ему заболевания достигли масштабов эпидемии. Прогнозируемое общее число взрослых с диабетом, по данным ряда авторов, возрастет до 592 миллионов в 2035 году. Сахарный диабет может привести к нефропатии, полинейропатии, ретинопатии, сердечно-сосудистым заболеваниям, ампутациям конечностей и т.д. Имеющиеся в современной литературе данные демонстрируют взаимосвязь ряда химических элементов с особенностями течения сахарного диабета 2-го типа. Известно, что микроэлементы участвуют в многочисленных биохимических реакциях, в том числе связанных с метаболизмом инсулина и глюкозы. Нарушение статуса микроэлементов при сахарном диабете может способствовать развитию инсулинорезистентности и развитию диабетических осложнений. С другой стороны, прогрессирование диабета может привести к изменению метаболизма микроэлементов в тканях. Цель работы – анализ имеющихся литературных данных об особенностях метаболизма цинка и меди у пациентов, страдающих сахарным диабетом 2-го типа. Проведенный анализ литературных источников показал, что уровни цинка и меди, сахарный диабет и его осложнения не просто коррелируют, но имеют сложную взаимосвязь. Для адекватного изучения этого вопроса необходимы дополнительные исследования, способные улучшить наше понимание роли этих микроэлементов в борьбе с окислительным стрессом и прогнозом сахарного диабета 2-го типа, так как результаты, доступные в литературе, все еще противоречивы.
СРАВНИТЕЛЬНАЯ ОЦЕНКА ПАТТЕРНОВ КУМУЛЯЦИИ ТОКСИЧНЫХ И ЭССЕНЦИАЛЬНЫХ МИКРОЭЛЕМЕНТОВ В ВОЛОСАХ ЖЕНЩИН ИЗ ГОРОДОВ ТВЕРЬ, ЯРОСЛАВЛЬ И ВОЛОГДА
Authors:   Ярославский государственный университет имени П. Г. Демидова (ЯрГУ им. П.Г. Демидова), Тиньков А.А. , Грабеклис А.Р. ,   Российский университет дружбы народов (РУДН), Коробейникова Т.В. ,   Российский университет дружбы народов (РУДН), Зайцева Ю.В. ,   Ярославский государственный университет имени П. Г. Демидова (ЯрГУ им. П.Г. Демидова), Флерова Е.А. ,   Ярославский государственный университет имени П. Г. Демидова (ЯрГУ им. П.Г. Демидова), Мазалецкая А.Л. ,   Ярославский государственный университет имени П. Г. Демидова (ЯрГУ им. П.Г. Демидова), Костина Н.Ф. ,   АНО «Центр биотической медицины», Степанов А.А. ,   АНО «Центр биотической медицины»
Published: January 2024

Цель исследования – изучение паттернов кумуляции эссенциальных и токсичных химических микроэлементов в волосах женщин трудоспособного возраста, проживающих в городах Твери, Ярославле и Вологде. Материалы и методы. Обследовано 411 взрослых женщин в возрасте от 18 до 60 лет, проживающих в Твери (n = 150), Ярославле (n = 108) и Вологде (n = 153), не задействованных в производственной сфере. Определение содержания химических элементов в волосах проводилось методом масс-спектрометрии с индуктивно-связанной плазмой (ИСП-МС). Результаты. Установлено, что для жителей Твери характерна выраженная кумуляция мышьяка, кадмия, а также тенденция к избыточному содержанию ртути в волосах. У женщин, проживающих в Ярославле, отмечалось увеличение содержания алюминия и тенденция к избыточной кумуляции олова в волосах. В свою очередь, у женщин из Вологды отмечалась интенсивная кумуляция таких токсичных металлов как алюминий, мышьяк, кадмий, и свинец. Для обследуемых из Твери было характерно увеличение частоты избыточной кумуляции железа, хрома и ванадия. Превышение референтных значений содержания железа в волосах также часто регистрировалось у женщин из Ярославля. В то же время у обследуемых из Ярославля и Вологды выявлена высокая частота дефицита меди и цинка. В группе обследуемых жителей Вологды, характеризующихся высоким уровнем свинца, выявлена обратная корреляция между содержанием цинка и свинца в волосах. Выводы. Женщины, проживающие в городах Вологде, Твери и Ярославле характеризуются различными избытками токсичных металлов на фоне дефицита меди и цинка. При этом последний, возможно, обусловлен избыточным воздействием свинца. Различия могут быть обусловлены функционированием различных предприятий, являющихся антропогенными источниками металлов, а также вносить значительный вклад в развитие экологически-обусловленных заболеваний.
ЭЛЕМЕНТНЫЙ СОСТАВ ВОЛОС У ЖИТЕЛЕЙ Г. ХАНТЫ-МАНСИЙСКА, СТРАДАЮЩИХ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ
Authors:   Ханты-Мансийская государственная медицинская академия, Корчина Т.Я. , Шарифов М.И. ,   Ханты-Мансийская государственная медицинская академия, Корчин В.И. ,   Ханты-Мансийская государственная медицинская академия
Published: January 2024

Цель работы – изучение в волосах жителей г. Ханты-Мансийска концентрации биоэлементов, принимающих участие в патогенезе артериальной гипертензии. Материалы и методы. Обследовано 115 взрослых некоренных жителей г. Ханты-Мансийска, более 10 лет проживающих на Севере: 52 человека с клинически подтвержденным диагнозом артериальной гипертензии (АГ): 24 мужчины и 28 женщин, а также 63 донора без АГ: 27 мужчин и 36 женщин (40,5±8,2 лет). Содержание химических элементов в волосах выявляли методами АЭС-ИП и МС-ИП. Результаты. У пациентов с АГ установлены более низкие концентрации всех изучаемых биоэлементов, кроме железа, оказывающих регулирующее влияние на артериальное давление ‒ кальция (М в 1,3 и Ме в 1,5 раза), магния (р=0,007), калия (р=0,023) и обладающих антиоксидантными свойствами ‒ меди и цинка (в 1,1 раза), селена (р<0,001), на фоне обладающего прооксидантными свойствами железа (М в 1,3 и Ме в 1,5 раза) по сравнению с подобными показателями контрольной группы. Выводы. Установлена значимо худшая обеспеченность биоэлементами, принимающими участие в патогенезе артериальной гипертензии, особенно магнием (р=0,001), калием (р=0,023) и селеном (р<0,001), у пациентов с артериальной гипертензией, проживающих на Севере, в сравнении с пациентами без данной патологии. По результатам анализа даны следующие тпрактические рекомендации: использовать сформированный региональный информационный массив данных о концентрации химических элементов в биосубстратах человека для прогнозирования, оценки и управления рисками, сопряженными с недостатком или избытком микроэлементов у человека на персональном и популяционном уровнях; внедрять инструментальные методы исследования биосубстратов и, в частности, элементного состава волос для повышения эффективности и информационной насыщенности профобследования населения; наряду с традиционными методами профилактики артериальной гипертензии проводить коррекцию элементного статуса у пациентов с использованием биологически активных добавок и обогащенных микронутриентами пищевых продуктов.
Disaster Management in Banjarmasin Through Communication Optimization
Authors: Yuliarti Astinana , Kumalawati Rosalina , Anggraini Rizky Nurita
Published: January 2024

Disaster communication is a process of creating, sending, and receiving messages from one or more people, which can be done directly or through the media, in various disaster contexts such as pre-disaster, when a disaster occurs, and post-disaster and generates responses or feedback. The role of disaster communication in conveying information is very important amidst technological advances in helping people reach information. This research aims to determine the extent of the disaster communication process carried out by the Banjarmasin City of Regional Disaster Management Agency/Badan Penganggulangan Bencana Daerah (BPBD) in conveying information and educating the public regarding disasters. This research uses a qualitative descriptive approach. The results of the research show that in the process of conveying information to the BPBD of the Banjarmasin community, most of them have carried out their activities quite well, such as Customer Focus, Situational Awareness, and Leadership Commitment, while two other indicators, namely Media Partnership and Soft and Hard Power, are not yet running so they need attention. specifically, such as the process of conveying information via social media still using reporting language rather than journalistic language rules, as well as the limited human resources needed to manage information related to disaster prevention and management before it is conveyed to the wider community.
Analisis Perkembangan Permukiman Kecamatan Paron Kabupaten Ngawi Tahun 2002-2018
Authors: PRAMESWARI GRIZKA LUTHFIAH
Published: January 2024

This study aims to: (1) Knowing the development of settlements. (2) The pattern of distribution of settlements. (3) Factors influencing the development of settlements in Paron District, Ngawi Regency in 2002-2018.
            The research was conducted in Paron District, Ngawi Regency. The population of this research is KK.The sample that will be used in this research is cluster sampling based on the number of additional residential lands and the increase in the number of heads of families.
There are 3 data analysis techniques based on the formulation of the problem, namely: (1) Settlement development using spatial analysis. (2) The pattern of distribution of settlements using the nearest neighbor analysis technique according to Bintarto (1991: 74). (3) Factors influencing the development of settlements from data processing after collecting data through various sources, which will then be classified. According to Yunus (1987: 73) there are nineteen significant reasons for the attractiveness of the population to move.

               The results of this study: (1) The area of settlements/buildings located in the research area in 2002 was 1,520.1 Ha, in 2010 the area was 1,809.9 Ha, resulting in an increase in the use of residential land as much as 289.8 Ha. In 2010 the settlement area was 1,809.9 Ha, in 2018 the total settlement area was 2,175.36 Ha, the changes that occurred were 365.46 Ha. (2) The pattern of distribution of settlements in Paron District has a result of Ta = 0.00016320772, it is concluded that it is close to a clustered pattern with T = 0-1. (3) The most dominant factor among the 19 things is: getting an inheritance with a voter turnout of 78 respondents or 52%. The second position wants to be independent with 50 respondents or 33%. The third position is close to the workplace with a voter turnout of 20 respondents or 13%.
Kesiapsiagaan Individu-Rumah Tangga dan Kelembagaan Masyarakat Dalam Menghadapi Bencana Longsor Lahan Di Kecamatan Ngargoyoso Kabupaten Karanganyar Tahun 2019
Authors: Muctharom Muchtarom -
Published: January 2024

This study aims (1) to know the level of preparedness of individuals - households in the face of landslides in the District Ngargoyoso Karanganyar and (2) to know the level of preparedness of community institutions in the face of landslides in the Ngargoyoso District, Karanganyar Regency.
This researchy resulted  the following conclusions. First, the level of individual-household preparedness in Ngargoyoso District is almost ready with 63 points. Ngargoyoso has 1 village with an individual-households preparedness level facing landslides with a very ready category, namely Kemuning with 80 points. Three villages have a level of preparedness with a ready category, namely Girimulyo with 67 points, Ngargoyoso with 71 points, and Segorogunung with 73 points. Two villages have a level of preparedness almost ready, namely Berjo with 60 points and Dukuh with 64 points. Three villages had a low level of preparedness, namely Jatirejo with 50 points, Nglegok with 49 points, and Puntukrejo with 50 points. Second, the level of community institutions preparedness to face landslides in Ngargoyoso District is almost ready with 58 points. Six villages in Ngargoyoso have the level of community institutions preparedness to face landslides in the almost ready category, namely Berjo (63 points), Dukuh (59 points), Girimulyo (64 points), Kemuning (61 points), Ngargoyoso (59 points), Nglegok (60 points); while three other villages in the category of less ready, namely Jatirejo (54 points), Puntukrejo (53 points), and Segorogunung (52 points).
Analisis Persebaran Dan Jangkauan Sekolah Menengah (SMA, MA, SMK) Di Kota Magelang, Jawa Tengah Tahun 2020
Authors: Ristanto Kurniawan Pujo , Rindarjono Gamal , Noviani Rita
Published: January 2024

Perencanaan fasilitas pendidikan SMA di suatu daerah perlu mempertimbangkan beberapa aspek pola distribusi. Penelitian ini menggunakan pendekatan geografis dengan aspek spasial. Penelitian ini juga menggunakan metode penelitian kualitatif dan kuantitatif dan analisisnya menggunakan analisis tetangga terdekat. Penelitian ini bertujuan untuk mengetahui sebaran dan jangkauan fasilitas pendidikan SMA. Hasil penelitian menunjukkan bahwa sebaran SMA di Kabupaten Magelang Utara mempunyai pola yang seragam, sedangkan sebaran di Magelang Tengah dan Selatan mempunyai pola acak, sedangkan untuk SMA (SMK) mempunyai pola mengelompok di Kabupaten Magelang Utara. dan pola acak untuk Kabupaten Magelang Tengah dan Selatan. Sekolah-sekolah tersebut mempunyai standar jangkauan yang sama, yaitu 3000 m. Seluruh SMA di kabupaten tersebut mampu menjangkau melampaui batas administratif Kota Magelang.

 

Kata Kunci: SMA, pola distribusi, jangkauan
Pengaruh Penggunaan Model Pembelajaran Inkuiri Terbimbing Disertai Google Earth Terhadap Kemampuan Berpikir Kritis Siswa Kelas XI IPS SMA Negeri Kebakkramat Tahun Ajaran 2022/2023
Authors: Ashari Rizki Nur
Published: January 2024

Tujuan penelitian adalah untuk mengetahui perbedaan pengaruh keterampilan berpikir kritis antara pembelajaran menggunakan model inkuiri terbimbing disertai media Google Earth dengan pembelajaran menggunakan model inkuiri terbimbing disertai peta. Populasi yang digunakan dalam penelitian ini adalah seluruh kelas XI IPS SMA Kebakkramat tahun ajaran 2022/2023 yang terdiri dari 5 kelas dengan jumlah siswa 150 orang. Sampel yang digunakan diambil dari populasi dan digunakan dalam penelitian ini ada 2 kelas yaitu XI IPS 1 dan XI IPS 2 yang berjumlah 72 siswa. Teknik pengumpulan data dalam penelitian ini adalah dengan menggunakan metode non tes dan metode tes. untuk metode non tes akan dikumpulkan melalui angket, observasi dan dokumentasi. Teknik analisis data yang digunakan dalam penelitian ini adalah statistik inferensial. Analisis statistik inferensial ini dilakukan untuk menguji hipotesis dengan menggunakan uji-t. Sebelum melakukan uji-t terlebih dahulu melakukan uji prasyarat seperti uji normalitas dan uji homogenitas. Dari hasil penelitian dan pembahasan yang dilakukan dapat disimpulkan bahwa: Terdapat pengaruh penerapan model inkuiri terbimbing disertai Google earth terhadap kemampuan berpikir kritis siswa kelas XI IPS 2 SMA Negeri Kebakkramat.

Kata Kunci : Inkuiri Terbimbing, Google Earth, kemampuan berpikir kritis
EXPERIMENTAL ANALYSIS OF HEAT RECOVERY WHEEL FOR TROPICAL CLIMATE
Authors: Rachman Arfidian , Yuana Dewi Rachman Arfita , Effendi Asnal , Nesti Lisa
Published: January 2024

Makalah ini menyajikan analisis eksperimental untuk menguji desain yang mengintegrasikan mekanisme roda pemulihan panas aktif ke dalam penangkap angin. Pemulihan panas roda termal dimasukkan ke dalam saluran penangkap angin dari sistem yang diusulkan. Eksperimen dilakukan untuk menguji bagaimana mekanisme pemulihan panas mempengaruhi kinerja penangkap angin, kemampuan sistem untuk menyediakan laju udara segar yang diperlukan. Model ruang ujian berukuran 4x4x3 meter diintegrasikan dengan model windcatcher. Tingkat ventilasi yang cukup bahkan dengan roda pemulihan panas yang berputar terhalang. Pemulihan aktif ini berpotensi mengurangi kebutuhan sistem pemanas ruangan secara memadai selain menyediakan ventilasi. Panas dalam aliran udara buang ditangkap dan dipindahkan ke aliran udara masuk, sehingga meningkatkan suhu antara 7-9 oC tergantung pada kondisi dalam/luar ruangan. Hal ini menunjukkan bahwa banyak usaha untuk pengembangan lebih lanjut dari ide tersebut, sehingga memungkinkan pengujian dan karakteristik perpindahan panas sistem dalam skala yang lebih besar.
A Study on the Fears of Crime among Foreigners Living in the Foreigner-Crowded Area
Authors:   Korean Association of Public Safety and Criminal Justice, Kim DongRok , Jung EuiRom
Published: January 2024

The fear of crime felt by foreigners residing in Korea is emerging as an important social problem. Most of the previous studies have focused on the fear of crime among domestic citizens, and studies on the fear of crime from the perspective of foreign residents are insufficient. Therefore, this paper aims to explore from various angles why foreigners residing in Korea are afraid of crime. To this end, it is necessary to systematically analyze the causes and effects of crime fear experienced by foreigners, and seek appropriate prevention and improvement measures. As a result of the analysis, it was found that regional order and Korean conflict had a statistically significant effect on crime fear. As a result of reviewing the results of studies dealing with the relationship between crime fears, it was found that conflicting results were presented, and it was intended to understand what causes these differences. In conclusion, this study is significant in that it considers crime fears in various aspects based on the models presented in previous studies. Therefore, it is expected that this study will contribute to promoting mutual understanding between foreigners and domestic residents and provide useful information for policy establishment and civic education.
Yeşilırmak Havzasında Düşük Akarsu Akımlarının Analizi
Authors: ÖZKAN Sümeyye , PARTAL Turgay
Published: January 2024

Kuraklık genel olarak bir bölgedeki yağışların kaydedilmiş normal seviyelerin önemli derecede altına düşmesiyle toprak ve su kaynaklarını olumsuz etkilemesi şeklinde tanımlanmaktadır. Kuraklık analizi için genellikle günlük düşük akım indisleri kullanılmaktadır. Bu çalışmada Yeşilırmak havzasında bulunan E14A002, E14A014, E14A018, D14A062 ve D14A106 nolu Kale, Sütlüce, Gömeleönü, Artova ve Alpudereköyü istasyonlarındaki akım gözlem istasyonlarına ait günlük verilerden oluşan 7 ve 30 günlük düşük akım verilerinden faydalanılmıştır. 31 yıllık veriler kullanılarak önce debi sürek grafikleri çıkartılmış ve bu grafikler üzerinden Q90, Q95 ve Q99 debileri okunarak düşük akımlar belirlenmiştir. Daha sonra 2, 5, 10, 25, 50 ve 100 yıllık tekerrür debileri 7 ve 30 günlük düşük akımlar için tahmin edilmiştir. Literatürde düşük akımlarda sıklıkla göz önüne alınan Normal, Lognormal ve Gumbel olasılık dağılımları kullanılmıştır. En uygun olasılık dağılımını belirlemek için Kolmogorov-Smirnov (K-S) testi yapılmıştır. Bütün dağılımlar %90 ve %95 istatistik anlam düzeyinde test edilmiştir. Son olarak da veriler Mann-Kendall ve Spearman’ın Rho trend analizine sokulmuş olup 7 günlük düşük akımlar için Sütlüce ve Artova istasyonlarında istatistiksel önemli azalan trend görülmüştür.
TVRI Yogyakarta in the era of disruption: Maintaining the existence of cultural wisdom through the broadcast of "Canthing
Authors: Nurrohmah Shinta , Rifa'i Akhmad
Published: January 2024

The existence of social media, which intensively displays similarities with television shows, has resulted in the decline of the television industry. Thus shifting the tastes of the younger generation by offering modern trends rather than local culture. This also happened on local Republic of Indonesia television, such as TVRI Yogyakarta. This article aims to reveal TVRI Yogyakarta's strategy for maintaining cultural wisdom through the Canthing program amid an era of media disruption. Data was obtained through observation, interviews, and documentation related to research. The results of this research show that TVRI Yogyakarta's strategy in maintaining the existence of the Canthing program is through the use of professional human resources, packaging the program with the main content of Javanese culture, methods of approaching and involving the youth community and socializing the program through advertisements on various TVRI Yogyakarta programs. by using social media as a form of divergence, convergence, and cyclone methods. TVRI Yogyakarta tries to provide innovations in the programs presented according to current developments so that they continue to be in demand by the current generation and beyond. This study contributes to the development of theories and concepts of the function of media as a cultural medium, which is also the orientation of Islamic communication. ***Eksisnya media sosial yang gencar menampilkan kemiripan dengan tayangan televisi mengakibatkan menurunnya industri pertelevisian sehingga menggeser selera generasi muda dengan penawaran trend modern daripada budaya lokalnya. Hal tersebut juga terjadi di televisi lokal Republik Indonesia seperti TVRI Yogyakarta. Tulisan ini bertujuan untuk membongkar bagaimana strategi TVRI Yogyakarta dalam menjaga eksistensi kearifan budaya di tengah era disrupsi media melalui program Canthing. Data diperoleh melalui observasi, wawancara, dan dokumentasi yang terkait dengan penelitian. Hasil dari penelitian ini diperoleh bahwa strategi TVRI Yogyakarta dalam mempertahankan eksistensi program Canthing melalui penggunaan sumber daya manusia yang profesional, pengemasan program dengan mengusung konten utama budaya Jawa, metode pendekatan dengan melibatkan komunitas anak muda, dan sosialisasi program melalui iklan pada berbagai program acara TVRI Yogyakarta dengan pemanfaatan media social sebagai bentuk dari metode divergensi, konvergensi, dan siklon. TVRI Yogyakarta berusaha memberikan inovasi baru terhadap program-program yang disajikan sesuai perkembangan zaman sehingga terus diminati oleh generasi masa kini dan seterusnya. Studi ini berkontribusi bagi pengembangan teori dan konsep fungsi media sebagai sarana kebudayaan, yang juga menjadi orientasi dari komunikasi Islam.
Frequency monitoring analysis of milling edge chatter in composites using WPD for frequency band selection
Authors: Liu Jinnan
Published: January 2024

In the milling process of composite materials, the initial chatter frequency is not obvious and is easily swamped by the rest of the signals, making frequency monitoring difficult, so the study proposes a chatter frequency monitoring method based on frequency cancellation algorithms and wavelet packet decomposition. The results of the experiments shown that the frequency cancellation algorithm can successfully remove invalid signals, such as spindle rotation frequency and cutter tooth frequency, and only keep the necessary signals, at which point the chattering frequency may be observed at a frequency of roughly 1333 Hz. The influence of the frequency bands s5, s9, s10, s12, and s13 after de-frequency removal should be avoided because they all have a low energy share of roughly 23 %, 0.9 %, 5 %, 10 %, and 16 %, respectively, and are less sensitive to chatter. For milling edge depths of 0.5 mm, 2 mm, and 4 mm, the average chatter thresholds were around 3.27, 2.9, and 2.89, respectively. It was challenging to pinpoint the chatter of the system because the empirical modal decomposition observed an average chatter energy entropy of just 1.55 and found that its fluctuations at the milling edge depth junction were insignificant. On the other hand, the chattering could be plainly seen since the energy entropy experienced a substantial and dramatic fluctuation at the intersection of the milling edge depth when it was about 2.9, 2.6, and 2.5, respectively. The experimental findings demonstrated that the frequency cancellation technique and wavelet packet decomposition-based chattering frequency monitoring approach can precisely track the chattering state of the system.
Molecular Characterization, Expression and In Situ Hybridization Analysis
of a Pedal Peptide/Orcokinin-type Neuropeptide in Cuttlefish Sepiella
japonica
Authors: Li Gong , Qiu Jiayin , Cao Huimin , Zheng Libing , Chi Changfeng , Li Shuang , Zhou Xu
Published: January 2024

Background::

Neuropeptide pedal peptide (PP) and orcokinin (OK), which are structurally
related active peptides, have been widely discovered in invertebrates and constitute the
PP/OK neuropeptide family. They have complex structures and play myriad roles in physiological
processes. To date, there have been no related reports of PP/OK-type neuropeptide in
cephalopods, which possess a highly differentiated multi-lobular brain.

Methods::

Rapid Amplification of cDNA Ends (RACE) was employed to obtain the open reading
frame (ORF) of PP/OK-type neuropeptide in Sepiella japonica (termed as Sj-PP/OK). Various
software were used for sequence analysis. Semi-quantitative PCR was applied to analyze the tissue
distribution profile, quantitative real-time PCR (qRT-PCR) was used to study spatio-temporal
expression throughout the entire growth and development period, and in situ hybridization (ISH)
was employed to observe the tissue location of Sj-PP/OK.

Results::

in the present study, we identified the ORF of Sj-PP/OK. The putative precursor of Sj-PP/
OK encodes 22 mature peptides, of which only tridecapeptides could undergo post-translationally
amidated at C-terminus. Each of these tridecapeptides possesses the most conserved and frequent
N-terminus Asp-Ser-Ile (DSI). Sequence analysis revealed that Sj-PP/OK shared comparatively
low identity with other invertebrates PP or OK. The tissue distribution profile showed differences
in the expression level of Sj-PP/OK between male and female. qRT-PCR data demonstrated
that Sj-PP/OK was widely distributed in various tissues, with its expression level increasing continuously
in the brain, optic lobe, liver, and nidamental gland throughout the entire growth and development
stages until gonad maturation. ISH detected that Sj-PP/OK positive signals existed in
almost all regions of the optic lobe except the plexiform zone, the outer edge of all functional
lobes in the brain, epithelial cells and the outer membrane layer of the accessory nidamental
gland. These findings suggest that Sj-PP/OK might play a role in the regulation of reproduction,
such as vitellogenin synthesis, restoration, and ova encapsulation.

Conclusion::

The study indicated that Sj-PP/OK may be involved in the neuroendocrine regulation
in cephalopods, providing primary theoretical basis for further studies of its regulation role in reproduction.
Factors Influencing Hypoglycemia in Type 2 Diabetes Mellitus Outpatients with State Health Insurance at Regional General Hospitals in Jakarta, Indonesia
Authors: Veryanti Putu Rika , Sauriasari Rani , Sartika Ratu Ayu Dewi , Elya Berna
Published: January 2024

Background:

Hypoglycemia is an acute episode that can lead to death in patients
with diabetes mellitus (DM). This condition is preventable with patient education, and
identifying factors influencing their occurrence is essential to creating effective and efficient
education. It also leads to prevention and control by re-organizing the service system and
diabetes policies. This study aimed to determine factors contributing to hypoglycemic episodes
in type 2 DM outpatients covered by the state-provided Jaminan Kesehatan Nasional (JKN)
health insurance.

Methods:

The study used a cross-sectional design and collected data from five regional general
hospitals in Jakarta, Indonesia. The outpatients were sampled consecutively from two hospitals
in September–November 2021, one in January–March 2022, and two others in April–June 2023.
Interviews produced primary data related to experienced hypoglycemic episodes, and medical
records provided secondary data on patients' clinical characteristics and treatments. Binary
logistic regression analysis was employed to process the contributing factors statistically.

Results:

From 501 patients who met the inclusion and exclusion criteria, it was found that the
prevalence of hypoglycemia was 53.3%. Factors that significantly increased hypoglycemic risk
(p < 0.05) were high HbA1C levels (OR 1.9; 95% CI 1.2–2.9), comorbidities (OR 1.6; 95% CI
1.1–2.4), insulin/sulfonylurea therapy (OR 2; 95% CI 1–4), non-smoking habit (OR 2.2; 95% CI
1.3–3.6) and physically active lifestyle (OR 1.8; 95% CI 1.2–2.6).

Conclusion:

The prevalence of hypoglycemia in type 2 diabetes mellitus (DM) outpatients with
the state-provided health insurance Jaminan Kesehatan Nasional (JKN) at general hospitals in
Jakarta is high. The diabetes self-management education (DSME) services provided by health
professionals for these outpatients must be further improved.
Impaired Awareness of Hypoglycemia and its Risk Factors among Diabetic
Patients in Jazan, Saudi Arabia: A Cross-Sectional Study
Authors: Oraibi Omar , Alameer Abdulelah , Dalak Mohammed , Alsharif Sawsan , Hakami Shatha A. , Sumayli Mohammed , Shami Ayman , Mohrag Mostafa , Madkhali Mohammed A. , Madkhali Mohammed Ali , Alhazmi Luai , Darraj Majid
Published: January 2024

Background:

Impaired awareness of hypoglycemia (IAH) is related to a three- to sixfold
increase in the risk of severe hypoglycemia in adults with type 1 diabetes mellitus (T1D).
This study aimed to assess the prevalence of IAH and its risk factors and determine the frequency
of hypoglycemic symptoms.

Objective:

This study aimed to assess the prevalence of IAH and its risk factors and determine
the frequency of hypoglycemic symptoms.

Methodology:

A cross-sectional study was conducted among T1D patients attending Jazan Endocrine
and Diabetes Center in Jazan province, Saudi Arabia. A total of 151 patients participated,
using the interview-based Clarke questionnaire, a validated eight-item questionnaire to evaluate
IAH. Scoring four or more answers as reduced awareness categorizes the participant as having
IAH.

Results:

The prevalence of IAH was 25.2% among the T1D patients. IAH was significantly associated
with body mass index (BMI; p = 0.034), occupation (p = 0.014), and blood glucose
monitoring methods (p = 0.027). Shaking and sweating were the most commonly reported
symptoms of hypoglycemia. A BMI of <25 kg/m2 was higher linked to hunger and speech difficulty
compared to a BMI of ≥25 kg/m2 (p < 0.05). Changing the insulin injection site was associated
with confusion, odd behavior, and speech difficulty (p < 0.05). Monitoring blood glucose
four times daily was associated with sweating, odd behavior, and incoordination (p = 0.024)
compared to monitoring less than four times daily (p < 0.05). A hemoglobin A1c (HbA1c) reading
of ≥7 was linked to odd behavior compared to an HbA1c reading of <7 (p = 0.032). Patients
committed to insulin injections were more likely to experience palpitations than non-committed
patients (p = 0.038). Each one-unit increase in age, monitoring blood glucose, and income was
associated with a decrease in the odds of IAH (OR of Age = 0.89, 95% CI: 0.83-0.95) (OR of
income = 0.10, 95% CI: 0.01-0.55). Moreover, individuals with a Body Mass Index (BMI)
greater than or equal to 25 (OR = 2.99, 95% CI: 1.13-8.25), employed individuals (OR = 18.2,
95% CI: 3.75-105), and diabetes duration of more than ten years (OR = 3.96, 95% CI: 1.31-
13.2) exhibited an increase in the higher risk of IAH.

Conclusion:

IAH was prevalent among T1D patients attending Jazan Endocrine and Diabetes
Center. The main associated factors included BMI, blood glucose monitoring method, and occupation.
Future research should investigate the underlying causes of the observed associations and
explore strategies to enhance the awareness of hypoglycemia.
Causal Relationships of Chronic Constipation and Irritable Bowel Syndrome with Digestive Tract Cancers: A Mendelian Randomization Study
Authors: Fan Rencai , Zhang Jiaqi , Shen Jiaofeng , Mao Chenkai , Li Shicheng , Zhuang Zhixiang
Published: January 2024

Background:

Chronic constipation and irritable bowel syndrome (IBS) manifest as
prevalent gastrointestinal disorders, while digestive tract cancers (DTCs) present formidable
challenges to global well-being. However, extant observational studies proffer uncertain insights
into potential causal relationships of constipation and IBS with susceptibility to DTCs.

Methods:

We executed Mendelian randomization (MR) analysis to establish causal connections
between these conditions and seven distinct categories of DTCs, including colorectal carcinoma
(CRC), hepatocellular cancer (HCC), esophageal malignancy (ESCA), pancreatic adenocarcinoma
(PAAD), biliary tract carcinoma (BTCs), gastric carcinoma (GC), and small intestine neoplasm
(SIC). Leveraging instrumental variables (IVs) obtained from GWAS data of the FinnGen
database, we employed a range of analytical methodologies, including inverse-variance
weighting multiplicative random effects (IVW_MRE), inverse-variance weighting fixed effects
(IVW_FE), maximum likelihood (ML), weighted median (WM), MR‒Egger regression, and the
MR-PRESSO test.

Results:

We observed a substantial linkage between genetically predicted constipation and increased
vulnerability to PAAD (OR = 2.29, 95% CI: 1.422-3.69, P = 0.001) via the IVW method.
Following the removal of outlier SNPs through MR-PRESSO, genetically predicted IBS
was affiliated with an increased risk of CRC (OR = 1.17, 95% CI: 1-1.37, P = 0.05). Nonetheless,
decisive causal correlations of constipation or IBS with other DTCs remain elusive.

Conclusion:

In summary, genetically predicted constipation was associated with an augmented
PAAD risk, and IBS was associated with an increased CRC susceptibility within European cohorts,
in agreement with some observational studies. Nevertheless, the causal associations of
constipation and IBS with other DTCs remain inconclusive.
Pharmacotherapy in SAH: Clinical Trial Lessons
Authors: Apostolakis Sotirios , Stavrinou Pantelis
Published: January 2024

:

Subarachnoid Haemorrhage (SAH) is a medical emergency with potentially devastating
outcomes. It is without doubt that over the past decades, there has been a radical change in the approach
towards patients with SAH, both in terms of the surgical as well as of the pharmacological
treatments offered. The present review aims to outline the principal data regarding the best practice
in the pharmacotherapy of SAH, as well as to sum up the emerging evidence from the latest clinical
trials. To date, nimodipine is the only evidence-based treatment of vasospasm. However, extensive
research is currently underway to identify novel substances with magnesium sulphate, cilostazol,
clazosentan and fasudil, demonstrating promising results. Antifibrinolytic therapy could help reduce
mortality, and anticoagulants, in spite of their associated hazards, could actually reduce the incidence
of delayed cerebral ischemia. The effectiveness of triple-H therapy has been challenged, yet
evidence on the optimal regimen is still pending. Statins may benefit some patients by reducing the
incidence of vasospasm and delayed ischemic events. As several clinical trials are underway, it is
expected that in the years to come, more therapeutic options will be added to the attending physician’s
armamentarium.
How Different Are the Influences of Mediterranean and Japanese Diets on the Gut Microbiome?
Authors: Moriki Dafni , Koumpagioti Despoina , Francino Maria Pilar , Rufián-Henares José Ángel , Kalogiannis Michalis , Priftis Kostas N. , Douros Konstantinos
Published: January 2024

:

The gut microbiome is a complex ecosystem, mainly composed of bacteria, that performs
essential functions for the host. Its composition is determined by many factors; however,
diet has emerged as a key regulator. Both the Mediterranean (MD) and Japanese (JD) diets have
been associated with significant health benefits and are therefore considered healthy dietary patterns.
Both are plant-based diets and although they have much in common, they also have important
differences mainly related to total calorie intake and the consumption of specific foods
and beverages. Thus, it has been hypothesized that they exert their beneficial properties through
different nutrients and bioactive compounds that interact with gut microbes and induce specific
changes on gut metabolic pathways. In this review, we present current data on the effects of the
MD and JD on the gut microbiome. Furthermore, we aim to examine whether there are differences
or shared effects on the gut microbiome of people who adhere to these dietary patterns.
Transient Central Diabetes Insipidus (Arginine Vasopressin Deficiency) Following SARS-CoV-2 Vaccination: A Case Report and Literature Review
Authors: Mazzeo Pierluigi , Ceccato Filippo , Manara Renzo , Mazzon Cinzia , Barbot Mattia
Published: January 2024

Introduction:

Since December 2019, severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) has affected millions of people, causing the COVID-19 global pandemic. The
use of novel technologies led to the development of different types of SARS-CoV-2 vaccines
that have reduced severe disease courses and related deaths. Besides the positive impact of vaccination
on the pandemic, local and systemic side effects have been reported; they are usually
mild to moderate, although also serious adverse events have been described.

Case Presentation:

A 21-year-old female was referred to our hospital for the recent onset of
severe polyuria and polydipsia, with the need for about 8 liters of daily water intake. The symptoms
developed seven days after the administration of the second dose of the mRNA-based
(Pfizer-BioNTech® BNT162b2) SARS-CoV-2 vaccine. In the suspicion of central diabetes insipidus
(DI) development, she started treatment with desmopressin (Minirin® tablets) 60 mg/day
with an improvement of symptoms and thirst. A thickening of the pituitary stalk was observed
at the pituitary MRI with loss of the posterior pituitary bright spot on T1 weighted images. To
confirm the diagnosis of central DI, both the water deprivation test and arginine stimulated copeptin
test were performed; whilst the former gave no clear-cut indication of DI, the latter
showed a reduced copeptin peak after arginine infusion consistent with the diagnosis of partial
central DI. Furthermore, the development of symptoms right after the second dose of the vaccine
strengthened the hypothesis that DI was related to the vaccination itself. After our evaluation,
there was a progressive reduction of desmopressin dose to a complete discontinuation with
the maintenance of a normal hydroelectrolytic balance. Clinical and biochemical follow-up was
performed by repeating a pituitary MRI and a second arginine-stimulated copeptin test 15
months after the diagnosis. This time, copeptin levels reached a significantly higher peak after
arginine stimulation that completely excluded central DI and at pituitary MRI, the thickening of
the pituitary stalk previously described was no longer visible.

Conclusion:

Neurohypophysitis can have an abrupt onset independently of the etiology.
Central DI is a rather exceptional event after SARS-CoV-2 vaccination but should be recalled
in case of sudden polyuria and polydipsia. DI is indeed reported even after SARS-CoV-2
infection, thus, this report should not discourage the use of mRNA-based vaccines.
Furthermore, our case demonstrates that full recovery of posterior pituitary function is possible
after immunization with anti-Covid-19 BNT162b2 vaccine. Further studies are needed to
clarify the possible mechanism relating to SARS-CoV-2 vaccination and this rare adverse
event.
Predicting Factors of Worse Prognosis in COVID-19: Results from a
Cross-sectional Study on 52 Inpatients Admitted to the Internal Medicine
Department
Authors: Lisco Giuseppe , Solimando Antonio Giovanni , Stragapede Assunta , De Tullio Anna , Laraspata Cristiana , Laudadio Carola , Giagulli Vito Angelo , Prete Marcella , Jirillo Emilio , Saracino Annalisa , Racanelli Vito , Triggiani Vincenzo
Published: January 2024

Background:

The initial phases of the COVID-19 pandemic posed a real need for
clinicians to identify patients at risk of poor prognosis as soon as possible after hospital admission.

Aims:

The study aimed to assess the role of baseline anamnestic information, clinical parameters,
instrumental examination, and serum biomarkers in predicting adverse outcomes of
COVID-19 in a hospital setting of Internal Medicine.

Methods:

Fifty-two inpatients consecutively admitted to the Unit of Internal Medicine “Baccelli,”
Azienda Ospedaliero – Universitaria Policlinico of Bari (February 1 - May 31, 2021) due
to confirmed COVID-19 were grouped into two categories based on the specific outcome:
good prognosis (n=44), patients discharged at home after the acute phase of the infection; poor
prognosis, a composite outcome of deaths and intensive care requirements (n=8). Data were
extracted from medical records of patients who provided written informed consent to participate.

Results:

The two study groups had similar demographic, anthropometric, clinical, and radiological
characteristics. Higher interleukin 6 (IL-6) levels and leucocyte count, and lower free triiodothyronine
(fT3) levels were found in patients with poor than those with good prognosis. Higher
IL-6 levels and leucocyte count, lower fT3 concentration, and pre-existing hypercholesterolemia
were independent risk factors of poor outcomes in our study population. A predicting risk
score, built by assigning one point if fT3 < 2 pg/mL, IL-6 >25 pg/mL, and leucocyte count
>7,000 n/mm3, revealed that patients totalizing at least 2 points by applying the predicting score
had a considerably higher risk of poor prognosis than those scoring <2 points (OR 24.35 (1.32;
448), p = 0.03). The weight of pre-existing hypercholesterolemia did not change the risk estimation.

Conclusion:

Four specific baseline variables, one anamnestic (pre-existing hypercholesterolemia)
and three laboratory parameters (leucocyte count, IL-6, and fT3), were significantly associated
with poor prognosis as independent risk factors. To prevent adverse outcomes, the updated
4-point score could be useful in identifying at-risk patients, highlighting the need for specific
trials to estimate the safety and efficacy of targeted treatments.