bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative analysis of visual outcomes following small-incision lenticule extraction with or without cyclotorsion compensation in eyes with high astigmatism: Contralateral eye study
Authors: Sachdev Gitansha S , Patekar Komal B , Ramamurthy Shreyas
Published: June 2023

Purpose:

To compare the visual outcomes in patients undergoing small-incision lenticule extraction (SMILE) for correction of myopic astigmatism (≥−1.50 D) with or without manual cyclotorsion compensation.

Methods:

A prospective, double-blinded, randomized, contralateral study was conducted in the refractive services of a tertiary eye care center. Eligible patients with bilateral high myopic astigmatism (≥1.5 D) and intraoperative cyclotorsion (≥5°) undergoing SMILE between June 2018 and May 2019 were included. Cyclotorsion compensation was performed using triple centration method before femtosecond laser delivery. Uncorrected and corrected distance visual acuity (UDVA and CDVA, respectively) measurement, manifest refraction, slit-lamp biomicroscopy, and corneal tomography were performed preoperatively and at 1 and 3 months’ postoperative visit. Astigmatic outcomes were analyzed using Alpins criteria.

Results:

A total of 30 patients (60 eyes) were included in this study. The patients underwent bilateral SMILE surgery, with manual cyclotorsion compensation in one eye (CC group, n = 30 eyes) and no cyclotorsion compensation in the other eye (NCC group, n = 30 eyes). Preoperative astigmatism and intraoperative cyclotorsion were −2.0 D and 7.03° ± 1.06° (CC) and −1.75 D and 7.24° ± 0.98° (NCC) (P = 0.472 and 0.240, respectively). No significant differences were noted in mean refractive spherical equivalent (MRSE), UDVA, CDVA, and refractive error between the two groups at 3 months’ postoperative visit. Astigmatic outcomes measured using Alpins criteria demonstrated no significant difference between the two cohorts.

Conclusion:

The cyclotorsion compensation technique provided no additional advantage in terms of astigmatic outcomes or postoperative visual quality, in eyes with high preoperative astigmatism and intraoperative cyclotorsion.
Comparative analysis of outcomes following topography-guided laser in situ keratomileusis using manifest refraction versus a new topographic analysis algorithm
Authors: Sachdev Gitansha S , Ramamurthy Shreyas , Soundarya B , Dandapani Ramamurthy
Published: June 2023

Purpose:

To compare the visual outcomes following topography-guided laser in situ keratomileusis (LASIK) treatment using manifest refraction versus a new topography analysis software.

Methods:

A prospective, randomized, observer-masked contralateral study was conducted in the refractive services of a tertiary eye care hospital in South India. Analysis of visual outcomes, corneal higher-order aberrations, and contrast sensitivity were performed at 3 months postoperative visit following uneventful topography-guided LASIK using the Wavelight EX500. One eye was treated with the Contoura platform using manifest refraction (Contoura), while the contralateral eye was treated using an ablation profile planned by the Phorcides Analytic Engine (Phorcides).

Results:

Sixty eyes of 30 patients were included in the study. At 3 months postoperative visit, the uncorrected distance visual acuity (UDVA) in the Contoura and Phorcides groups was logarithm of the minimal angle of resolution (logMAR) 0.04 ± 0.07 and logMAR 0.06 ± 0.1, respectively (P = 0.483). Postoperative manifest refractive spherical error (MRSE) was 0.12 ± 0.22 and − 0.06 ± 0.20 D in the Contoura and Phorcides groups, respectively (P = 0.338). Although higher number of eyes demonstrated a gain in one or more lines of corrected distance visual acuity (CDVA) in the Contoura group (16.6% vs. 6.6%), the difference was not statistically significant (P = 0.361). Vector analysis (Alpins criteria) for postoperative cylinder, contrast sensitivity measurement, and corneal higher-order aberration profile showed no significant difference between the two groups at 3 months postoperative visit (P = 0.213, 0.514, and 0.332, respectively).

Conclusion:

Quantitative and qualitative visual outcomes with the Phorcides Analytic Software were similar to the Contoura treatment using manifest refraction.
Different strokes for anterior capsulorhexis in pediatric cataract
Authors: Chattannavar Goura , Lasrado Adeline S , Kekunnaya Ramesh
Published: June 2023

Background:

A successful outcome in pediatric cataract surgery is determined by an intact, curvilinear anterior capsulotomy which is dependent on the type and density of cataract, the morphology of the anterior capsule, and associated anterior segment pathologies.

Purpose:

This video highlights 10 different techniques which can be used for capsulorhexis in pediatric cataract.

Synopsis:

The choice of technique for capsulorhexis in pediatric cataract is on case basis, namely the gold standard manual capsulotomy aided by rhexis forceps (1. Standard capsulorhexis/2. Vitrector, Vitrectorhexis), with an assistance from capsular staining (3. Blue-rhexis), or by coaxial illumination (4. Coaxial-rhexis) or by just the sheen of capsule (5. Sheen-rhexis). The anterior chamber can be maintained using ophthalmic visco-elastic device (Visco-rhexis) or by irrigation fluid (6. Hydro-rhexis). A speed-breaker in the routine capsulotomy is the presence of plaque which is managed by rhexis forceps (7. Plaque-rhexis) or by a vitrector (vitrectorhexis) or a pair of micro-scissors (8. Scissor rhexis). Above all, the technology of femto-second-laser-assisted (9. Femto-rhexis) and zepto-pulse-precision capsulotomy (10. Zepto-rhexis) is also illustrated.

Highlights:

This video highlights the 10 different techniques of capsulorhexis in pediatric cataract surgery.

Video Link:
https://youtu.be/TgDrk5RYdbI

Key words: Caspulotomy, capsulorhexis, pediatric cataract
Repeat deep anterior lamellar keratoplasty (DALK) for failed primary DALK
Authors: Arora Ritu , Sanoria Abhilasha , Jain Parul , Gupta Isha , Gupta Palak
Published: June 2023

Purpose:

To evaluate the effectiveness of repeat deep anterior lamellar keratoplasty (DALK) in patients of previous failed DALK.

Methods:

A retrospective analysis of records of seven patients who had undergone repeat DALK following the failure of the primary DALK was done. The indications for repeat surgery, time elapsed since the first surgery, and pre- & postoperative best-corrected visual acuity (BCVA) were noted for all the patients.

Results:

The follow-up period ranged between one- to four-year post repeat DALK. The indication of primary DALK was keratoconus with vernal keratoconjunctivitis (VKC) (n = 3), corneal amyloidosis (n = 2), Salzman nodular keratopathy (n = 1), and healed keratitis (n = 1). The need for repeat surgery arose when the BSCVA dropped to less than 20/200. The time interval elapsed since the first surgery ranged from two months to four years. Postoperatively, the BSCVA improved from 20/120 to 20/30 at the end of one-year post repeat DALK in all except one patient. All regrafts were clear at the most recent examination, performed after a mean period of 18 months after the secondary graft. No complication was encountered during the resurgery. The dissection of the host bed was easier in the second surgery owing to weaker adhesions.

Conclusion:

The prognosis for repeat DALK for failed DALK is excellent, and the outcomes of secondary grafts were comparable to those of primary DALK grafts. Re DALK offers the advantage of an easier dissection and lower chances of graft rejection compared to penetrating keratoplasty.
The deceptive coloboma
Authors: Ratra Dhanashree , Mohan Sashwanthi , Nadig Ramya , Kashyap Himanshu
Published: June 2023

Background:

Scleral fistulas are known to develop following blunt trauma in patients with retinochoroidal coloboma. These cases can be managed by surgical options such as silicone buckles, or with glue and scleral patch graft. Some cases have been shown to close spontaneously. We report the first-ever case managed by vitrectomy, endophotocoagulation, and gas tamponade.

Purpose:

We present a rare and interesting case of an atypical choroidal coloboma with traumatic scleral fistula due to blunt trauma manifesting with hypotony-related disc edema, maculopathy, and chorioretinal folds, which was managed surgically with vitrectomy, endophotocoagulation, and gas tamponade with a good anatomical and visual outcome.

Synopsis:

The video contains the case description and surgical management of a traumatic scleral fistula in a patient with atypical superotemporal choroidal coloboma. The patient developed hypotonic maculopathy and disc edema after 3 months following a blunt trauma sustained in a road traffic accident. A scleral fistula was suspected at the temporal edge of the coloboma but could not be accurately localized. In addition, due to the edge effect of the coloboma, the external repair was difficult. Hence, vitrectomy with internal tamponade was attempted.

Highlights:

The video highlights a different surgical approach to managing a traumatic scleral fistula at the edge of a retinochoroidal coloboma. There was a risk of leakage of intravitreal fluid into the orbit through the fistula; however, the gas bubble gave a better tamponade due to higher surface tension. It sealed the fistula presumably by creating a trap-door-like effect. The endophotocoagulation helped create adhesion between the tissues at the edge of the coloboma effectively sealing it. This was followed by a rapid recovery of the hypotony-related problems with good vision. Traumatic scleral fistula, at a difficult place such as the edge of a coloboma, can be successfully closed from an internal approach with vitrectomy, endolaser, and gas tamponade.

Video link:
https://youtu.be/6rxgtFyy6cw

Key words: Gas tamponade, retinochoroidal coloboma, scleral fistula, traumatic scleral rupture, vitrectomy
Surgical management of lifebuoy cataract
Authors: Maamouri Rym , Ouederni Meriem , Gharbi Zeineb , Cheour Monia
Published: June 2023

Lifebuoy cataract is a rare form of congenital cataract with anatomical characteristics. Herein, we present a case of an otherwise healthy 42-year-old female with a long-standing history of blurred vision. Examination showed the presence of esotropia and bilateral horizontal nystagmus. Visual acuity was limited to light perception in both eyes. Slit-lamp examination showed a calcified lens capsule with the absence of lens material in the right eye and the presence of an annular cataract in the left eye, corresponding to a unilateral lifebuoy cataract. She underwent cataract surgery with intraocular lens implantation. We report the clinical findings, anterior segment optical coherence tomography (AS-OCT), and surgical management tips. We noticed that during surgery, both anterior capsulorhexis and central membrane removal were the most challenging steps due to the absence of central nucleus and the strong adherence of central membrane to the anterior hyaloid.
Connective tissue disorders and eye: A review and recent updates
Authors: Asif Mohamed I. , Kalra Nidhi , Sharma Namrata , Jain Neha , Sharma Mohita , Sinha Rajesh
Published: June 2023

Collagen vascular disorders (CVDs), also known as connective tissue diseases (CTDs), are a heterogeneous group of entities that affect the connective tissues and are capable of causing end-organ damage to multiple systems, primarily cardiopulmonary and musculoskeletal. However, the occurrence and severity are highly variable among patients. Ocular involvement occurs in a significant number of these disorders and may precede the onset of other extraocular features, thereby serving as an important marker in the diagnosis of these diseases. A timely and accurate diagnosis enables the management of complications. CTDs are primarily immune-mediated inflammatory diseases; however, classifications have encompassed heritable disorders affecting collagen-containing structures and disorders of vascular development. A review of literature published until 25 January 2022 and collected from various databases using the relevant keywords was conducted. All publications (original articles, review articles, as well as case reports) describing the ocular features in CTDs were studied in detail. The objective of this review is to recognize the common ophthalmic presentations of various autoimmune and heritable CTDs, distinguish them from overlapping diseases, elaborate on the prognosis and management of these varied eye presentations, and deliberate on their impact on other ophthalmic surgeries.
Encapsulated bleb with scleral fistula - A diagnostic dilemma treated by a simple procedure
Authors: Satpute Kanchangouri , Balaji Veena , Dada Tanuj , Angmo Dewang
Published: June 2023

We present a case of post-trabeculectomy encapsulated dysesthetic bleb with scleral fistula, managed successfully with autograft. The child was operated on twice before for trabeculectomy, and intraocular pressure (IOP) recorded was in the normal range for the initial few years. This time child presented with a large encapsulated dysesthetic bleb with borderline IOP. As the IOP was on the lower side, an underlying scleral fistula was suspected and planned for bleb revision with a donor patch graft. We describe the novel technique of bleb revision along with the repair of the scleral fistula with an autologous free fibrotic Tenon’s tissue graft instead of a donor patch graft with a successful outcome.
Suture manipulation post-trabeculectomy: A practical guide
Authors: Venkataraman Prasanna , Shroff Anahita
Published: June 2023

Background:

Trabeculectomy is the gold standard filtration surgery for diverting aqueous from anterior chamber to the subconjunctival space. More than the surgery, postoperative follow-ups and management of the blebs play a critical role in the long-term success. This video is aimed at showing the real-world management of blebs postoperatively.

Purpose:

This video will serve as a practical guide to the postoperative management of trabeculectomy blebs with specific focus on the suture manipulation.

Synopsis:

This video will demonstrate various suturing techniques of trabeculectomy and their manipulation in the postoperative period. Complications related to each will be discussed.

Highlights:

We demonstrate how to place and remove, releasable, and fixed sutures. We also address the practical points on why and when to remove the sutures. Suture-related complications and their management have been shown along with practical examples.

Video Link:
https://youtu.be/2WFQJAPyOvY

Key words: Bleb, bleb massage, laser suture lysis, needling, releasable sutures, trabeculectomy
Aurolab aqueous drainage implant implantation made easy: A video-based step-by-step guide
Authors: Maheshwari Devendra , Gupta Shivam , Tara Dodum Techi , Pillai Madhavi Ramanatha , Rengappa Ramakrishnan , Pawar Neelam
Published: June 2023

Background:

Glaucoma is one of the major causes of irreversible blindness in the world, with trabeculectomy still being the primary surgical modality for the management of glaucoma. Glaucoma drainage devices (GDDs) have been conventionally used for the treatment of refractory glaucoma and are found to be beneficial in eyes with prior unsuccessful filtration surgeries and primary choice of surgery in certain glaucoma. Aurolab aqueous drainage implant (AADI) is a nonvalved device useful in refractory glaucoma to achieve low intraocular pressure (IOP). The device has been commercially available in India since 2013 and is like the Baerveldt glaucoma implant in design and function. AADI being the most economical and effective GDD in controlling IOP is becoming a popular choice among ophthalmologist in developing countries. AADI surgery has steep learning curve due to large end-plate surface area which needs a rigorous conjunctival dissection, muscle hooking, meticulous plate fixations, and careful tube ligations and insertion. There are different techniques of performing AADI surgery, but the authors have tried to simplify the complex surgery for easy and catchable learning of the procedure by novice surgeon with their experience and have elaborated a step-wise most effective way of performing surgery.

Purpose:

This video-based skill transfer depicts steps of AADI surgery with compilation of various modifications and authors’ tips and tricks to novice surgeons.

Synopsis:

This video depicts detailed steps of AADI surgery with micro-points and authors experience. Video also shows various tailor-made modifications of surgical techniques for different case scenarios.

Highlights:

Steps of AADI surgery, modifications, and surgical pearls.

Video Link:
https://youtu.be/vmVqBb2FvP4

Key words: Aurolab aqueous drainage implant, glaucoma drainage device, refractory glaucoma
Commissioning and Performance Evaluation of Varian TrueBeam Linear Accelerator
Authors: Dutta Bidisha , Goswami Shrutisikha , Moran Sushmita , Talukdar Phulkumari
Published: June 2023

Aim:

The aim of this study is to present a report on the commissioning results of the Varian TrueBeam machine with available photon energies so that it can benefit medical physicists during the entire commissioning process.

Subjects and Methods:

All tests were performed as per the recommendation of the Atomic Energy Regulatory Board. The beam profiles and percentage depth dose of both photon and electron beams were measured with Sun nuclear Radiation Field Analyzer and 0.125 cc ionization chamber. Output accuracy and consistency of photon and electron beams were measured using 0.6 cc cylindrical ionization chamber and 0.350 cc parallel plate ionization chamber, respectively. To measure the congruency of radiation and optical field and isocenter check with respect to gantry, collimator, and couch, self-developed films were used.

Results:

Isocenter shift due to gantry, collimator, and couch, rotation was found to be within ± 2-mm diameter circle. Congruency of optical and radiation fields was measured for symmetric fields 5 cm × 5 cm, 10 cm × 10 cm, 20 cm × 20 cm, and 30 cm × 30 cm for all available energy and was within ± 2 mm. Dosimetric leaf gap value for the multi-leaf collimator was measured with 0.125 cc ionization chamber and values are −0.853 mm, −1.106 mm, −1.097 mm, −0.765 mm, and −1.005 mm for energies 6 MV, 10 MV, 15 MV, 6 flattening filter free (FFF), and 10 FFF, respectively.

Conclusions:

All electrical, mechanical, dosimetric, and safety measurement were found to be within permissible limits. Before clinical use, the beam data are crosschecked with point dosimetry, portal dosimetry, and MapCHECK two-dimensional detector array and results are within tolerance.
Correlation of Hepatobiliary Ultrasound Findings with CD4+ Count and Viral Load in Adult Patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome in South-East Nigeria
Authors: Obieje Kanayo Gerald , Ebubedike Uzoamaka Rufina
Published: June 2023

Background:

The human immunodeficiency virus (HIV) belongs to a cytopathic retrovirus that cause acquired immune deficiency syndrome (AIDS) over time. Due to the suppression of the immune system by this retrovirus, many disease processes may occur. Abdominal ultrasonography is a cost-effective, safe, accessible, and noninvasive means of demonstrating the hepatobiliary manifestations of HIV/AIDS. CD4+ count and viral load are the two important markers.

Objective:

This study aims at correlating the hepatobiliary ultrasound findings with CD4+ count and viral load in adult patients with HIV/AIDS in South East, Nigeria.

Materials and Methods:

This was a 12-month cross-sectional study of 210 adult patients with HIV/AIDS, carried out from January 2020 to December 2021 in South East, Nigeria. Each patient's abdomen was scanned using 2.5–5 MHz curvilinear on an “ALOKA” ultrasound machine. The viral load and CD4+ count results were collected from the patient's folders at the Medical Records Department. Statistical analysis was done using IBM SPSS, version 21.0 (IBM Corporation, Armonk, NY, USA, 2011).

Results:

A total of 210 patients with HIV/AIDS who had a mean age of 39.1 ± 10.9 years, were recruited into this study. Patients with severe CD4+ class and high viral load had the highest proportion of abnormal hepatobiliary findings (28.6% and 25.7%, respectively). Hepatomegaly, hyperechoic liver, coarse parenchyma, ascites, gallbladder abnormalities, and lymphadenopathy were the common ultrasound findings, some of which showed statistically significant correlation with CD4+ count and viral load.

Conclusion:

Many of the hepatobiliary ultrasound findings showed statistically significant correlation with CD4+ count and viral load.
Early Experience of High-Dose-Rate Interstitial Brachytherapy for Prostate Cancer in Nigeria
Authors: Abdus-salam Abbas Adesina , Takure Augustine O. , Akinlade Bidemi I. , Idowu Olusola Kayode , Folorunso Sharif Adeniyi , Olabu muyi Adeniyi Adedayo , Jimoh Mutiu Alani , Ayorinde Folasire , Ntekim Atara Isaiah , Oladeji Adebayo Afolabi , Oyekunle Emmanuel Oyeyemi , Sarimiye Foluke Oladele , Ogunnorin Babatunde Olutoye , Adenipekun Adeniyi Abidemi
Published: June 2023

Before now, brachytherapy in public hospitals in Nigeria has focused almost exclusively on treating gynecological tumors, especially cervical cancer. Three years ago, the Federal Government procured brachytherapy equipment for six hospitals in Nigeria, including the University College Hospital, Ibadan. In this article, we present our experience as Nigerian pioneers using high-dose-rate brachytherapy modality for prostate cancer treatment, including challenges (being) encountered and recommendations for other centers planning to start this service in the country and beyond.
Dynamics of mean-field bosons at positive temperature
Authors: Deuchert Andreas , Caporaletti Marco , Schlein Benjamin
Published: June 2023

We study the time evolution of an initially trapped weakly interacting Bose gas at positive
temperature, after the trapping potential has been switched off. It has been recently shown in
Deuchert–Seiringer (2021) that the one-particle density matrix of Gibbs states of the interacting
trapped gas is given, to leading order in

N

, as

N \rightarrow \infty

, by that of the ideal gas, with the condensate wave function replaced by the minimizer of the Hartree energy functional. We show that this structure is stable with respect to the many-body evolution in the following sense: the dynamics can be approximated in terms of the time-dependent Hartree equation for the condensate wave function and in terms of the free evolution for the thermally excited particles. The main technical novelty of our work is the use of the Hartree–Fock–Bogoliubov equations to define a fluctuation dynamics.
The étale-open topology and the stable fields conjecture
Authors: Johnson Will , Tran Chieu-Minh , Walsberg Erik , Ye Jinhe
Published: June 2023

For an arbitrary field

K

and a

K

-variety

V

, we introduce the étale-open topology on the set

V(K)

of

K

-points of

V

. This topology agrees with the Zariski topology, Euclidean topology, or valuation topology when

K

is separably closed, real closed, or

p

-adically closed, respectively. Topological properties of the étale-open topology correspond to algebraic properties of

K

. For example, the étale-open topology on

\mathbb{A}^1(K)

is not discrete if and only if

K

is large. As an application, we show that a large stable field is separably closed.
PFH spectral invariants on the two-sphere and the large scale geometry of Hofer’s metric
Authors: Cristofaro-Gardiner Daniel , Humilière Vincent , Seyfaddini Sobhan
Published: June 2023

We resolve three longstanding questions related to the large scale geometry of the group of Hamiltonian diffeomorphisms of the two-sphere, equipped with Hofer’s metric. Namely: (1) we resolve the Kapovich–Polterovich question by showing that this group is not quasi-isometric to the real line; (2) more generally, we show that the kernel of Calabi over any proper open subset is unbounded; and (3) we show that the group of area and orientation preserving homeomorphisms of the two-sphere is not a simple group. We also find, as a corollary, that the group of area-preserving diffeomorphisms of the open disc, equipped with an area form of finite area, is not perfect. Central to all of our proofs are new sequences of spectral invariants over the two-sphere, defined via periodic Floer homology.
Outbreak of carbapenem-resistant Enterobacterales at a long-term care facility in Seoul, Korea: surveillance and intervention mitigation strategies
Authors: Park Yoojin , Son Euncheol , Choe Young June , Kang Cho Ryok , Roh Sangmi , Hwang Young Ok , Cho Sung-il , Bang Jihwan
Published: June 2023

OBJECTIVES: Because effective decolonization options are not available, and treatment options are limited, carbapenem-resistant Enterobacterales (CRE) constitute increasingly threatening nosocomial pathogens. To prevent CRE-associated transmission and ensure patient safety, healthcare personnel and everyone in contact with CRE-infected patients must implement stringent infection control practices. This report describes a CRE outbreak, possibly related to a caregiver at a long-term care facility (LTCF), and presents a new surveillance model to improve the infection control of CRE in Seoul, Korea.METHODS: The Seoul Metropolitan Government surveillance system identified an outbreak of CRE in an LTCF in 2022. We obtained data on the demographic characteristics and contact histories of the inpatients, medical staff, and caregivers. To isolate the inpatients and employees exposed to CRE, we used rectal swab samples and environmental sampling during the study period (May-December 2022).RESULTS: We identified 18 cluster cases (1 caregiver and 17 inpatients) and 12 sporadic cases with CRE, and conducted a complete 197-day follow-up of all cases in the LTCF’s isolation wards.CONCLUSIONS: This investigation demonstrated that our surveillance model and targeted intervention, based on the cooperation of the municipal government, public health center, and infection control advisory committee, effectively contained the epidemic at the LTCF. Measures to improve the compliance of all employees in LTCFs with infection control guidelines should also be adopted.
Finding on Convergence of the Flint Hills and Cookson Hills Series based on a Summation Formula of Adamchik and Srivastava involving the Riemann Zeta Function
Authors: Zapata Carlos Hernán López
Published: June 2023

This article showcases significant progress in solving two renowned problems in the calculus of series: the Flint Hills and Cookson Hills series. For almost twenty years, a long-standing question has remained unanswered in regard to their convergence. Mainly, proving the convergence of the Flint Hills series would significantly impact the redefinition of the upper bound for the irrationality measure of the number π. One of the results presented in this article is that the Flint Hills series converges to 30.3144... which leads to a redefinition of the upper bound for the irrationality measure of π, specifically μ(π)≤ 2.5. This work proposes a transformation that solves the mystery of the Flint Hills and Cookson Hills series. It is based on a summation formula developed by mathematicians Adamchik and Srivastava. By leveraging a specialized series supported by the Riemann zeta function, this approach successfully transforms the original Flint Hills and Cookson Hills series into novel convergent versions with unique significance. The resulting sequences linked to these series are positive and bounded and satisfy convergence. Moreover, this article extends the Flint Hills series when the cosecant function has an arbitrary complex argument n+iβ, with i=√(-1), establishing a new series representation based on the polylogarithm 〖Li〗_3 (e^i2k), with k=1,2,3,…, e the Euler’s number, which bears resemblance to the famous integral of the Bose-Einstein distribution as a relevant finding. This is a never-seen-before link between the Flint Hills series and polylogarithms. Furthermore, a relationship between the Apéry constant and the Flint Hills and Cookson Hills series has been established. This article presents a significant breakthrough in the calculus of series by introducing a new method based on the Riemann Zeta function and logarithmical expressions derived from the Adamchik and Srivastava summation formula. The novel approach extends the analysis of convergence criteria for series, addressing ambiguous cases characterized by abrupt jumps. Thus, the Flint Hills series converges to 30.3144... and the Cookson Hills series to 42.9949... as proved in this article.
Obsesif Kompulsif Bozukluğu Olan Bireylerde Din ve Maneviyatın Hastalık Sürecindeki Etkisi Üzerine Nitel Bir Çalışma
Authors: YILMAZ Beyzanur
Published: June 2023

Bu makale din ve maneviyat olgularının OKB'li bireylerin hastalık sürecindeki etkisini ortaya koymaya çalışan araştırma sonuçlarına değinmiştir. Nitel araştırma bulgularından elde edilen veriler ışığında oluşturulan OKB’li bireylerin sınıflandırılması ile ortaya çıkan bazı prototipleri kişilerin bu olguları ne şekilde anlamlandırdığı ve sorunları ile başa çıkmasına katkı sağladığını açıklamaktadır. Makale, Obsesif Kompulsif Bozukluk (Saplantı/Zorlantı Bozukluğu) ile ilgili tıbbi literatürü, devamında ise bu hastalığın dini ve manevi boyutunu teorik ve pratik çerçevede ele almıştır. Teorik bilgiye bu kapsamda araştırmanın sonuç kısmını anlamlandırmaya yardımcı olmak hasebiyle makalede yer vermenin gerekli olduğu görülmüştür. Pratik çerçevede ise makalede, katılımcıların araştırmada kullanılan 6 açık uçlu anket sorusuna verdikleri cevapların nitel veri analizi olan betimsel analize göre elde edilen bulguları yer almaktadır. Bu araştırmada, bireylerin rahatsızlık ile baş etme yöntemlerine göre konu çerçevesinde sınıflandırılan hangi dini manevi prototipe girdiği konusunda bilgi verilmiştir. Bu prototipler araştırmadan elde edilen veriler bağlamında oluşturulmuş olup, ruhsal tekâmülcüler, mukayeseli şükürcüler, teslimiyetçiler ve imtihana bağlananlar olarak sınıflandırılmıştır. Ankara Numune Hastanesi Psikiyatri Kliniği ve Ankara ili içerisindeki OKB tanısı almış 50 kişi üzerinde yapılan araştırma sonucunda ortaya çıkan verilerin analizi, din ve maneviyat olgusunun kişilere büyük oranda “tedavi sırasında kişiyi manevi açıdan güçlendirmeye” yönelik olumlu katkı sağladığını göstermektedir.
Một số yếu tố tiên lượng kết quả thai kỳ bất lợi trên thai phụ bị lupus ban đỏ hệ thống tại Bệnh viện Bạch Mai
Authors: Nguyễn Việt Hà , Phạm Bá Nha , Đoàn Mạnh Tín
Published: June 2023

Mục tiêu: 1. Nhận xét kết quả thai kỳ và biến chứng sản khoa ở thai phụ bị lupus ban đỏ hệ thống có thai ở Bệnh viện Bạch Mai. 2. Tìm hiểu một số yếu tố liên quan đến kết quả thai kỳ bất lợi ở thai phụ bị lupus ban đỏ hệ thống.

Đối tượng và phương pháp nghiên cứu: Mô tả tiến cứu trên 30 thai phụ bị lupus ban đỏ hệ thống được quản lý và kết thúc thai kỳ tại Bệnh viện Bạch Mai từ tháng 1/2022 đến tháng 1/2023. Kết quả thai kỳ bất lợi là 1 trong các tình trạng sau: (i) thai chết lưu sau 12 tuần, (ii) đẻ trước 36 tuần do thai chậm phát triển trong tử cung, tăng huyết áp, tiền sản giật, (iii) tử vong sơ sinh (iv) sơ sinh nhẹ cân so với tuổi thai.

Kết quả: Kết quả thai kỳ bất lợi xảy ra ở 14 thai kỳ (46,7%): 2 (6,7%) tử vong sơ sinh, 5 (16,7%) đẻ non do TSG, 7 (23,3%) đẻ non do thai chậm phát triển, 8 (26,7%) sơ sinh nhẹ cân so với tuổi thai. Nhiễm khuẩn hậu sản có 5 bệnh nhân (16,7%): 3 (10,0%) nhiễm khuẩn vết mổ, 2 (6,7%) nhiễm khuẩn tử cung. Các yếu tố liên quan đến kết quả thai kỳ bất lợi là nồng độ C3 giảm (OR 8,07, 95%CI 1,54 - 42,32), protein niệu ≥ 1 g/L (OR 6,0, 95%CI 1,003 - 35,91) và kháng đông lupus (OR 7,0, 95%CI 1,14 - 42,97).

Kết luận: Kết quả thai kỳ bất lợi xảy ra ở 46,7% bệnh nhân lupus ban đỏ hệ thống có thai. Tỷ lệ nhiễm khuẩn hậu sản là 16,7%. Giảm nồng độ C3, protein niệu ≥ 1 g/L và kháng đông lupus dương tính là các yếu tố tiên lượng kết quả thai kỳ bất lợi.
Các yếu tố liên quan đến tăng nồng độ CA125 trên bệnh nhân ung thư biểu mô buồng trứng tái phát tại Bệnh viện Từ Dũ
Authors: Nguyễn Hồng Hoa , Phạm Văn Mạnh , Trần Minh Lộc
Published: June 2023

Đặt vấn đề: Cancer Antigen 125 (CA125) là dấu ấn ung thư giúp chẩn đoán và theo dõi điều trị ung thư biểu mô buồng trứng (UTBMBT) tái phát. Do đó, chúng tôi thực hiện nghiên cứu nhằm mục tiêu: 1) Mô tả đặc điểm nồng độ CA125 ở bệnh nhân (BN) UTBMBT tái phát tại bệnh viện Từ Dũ và 2) xác định các yếu tố liên quan đến tăng nồng độ CA125 ở BN UTBMBT tái phát.

Đối tượng, phương pháp nghiên cứu: Mô tả loạt ca hồi cứu 126 BN UTBMBT tái phát tại Bệnh viện Từ Dũ từ 01/01/2016 đến 30/06/2022.

Kết quả: Nồng độ CA125 trung vị, nhỏ nhất và lớn nhất lần lượt là 59,2 U/ml, 5 U/ml và 2915 U/ml. 94 BN UTBMBT tái phát (74,6%) tăng CA125 (≥ 35 U/ml), thời gian tái phát sinh hóa trung bình ở BN tăng CA125 là 1,9 ± 1,8 tháng. Nồng độ CA125 trước điều trị lần đầu liên quan đến tăng CA125 ở BN UTBMBT tái phát (OR 1,001; KTC 95% 1,00001 - 1,002; p = 0,047). Tỷ lệ hóa trị hỗ trợ cao hơn và phẫu thuật giảm khối thấp hơn trong điều trị BN UTBMBT tái phát tăng CA125 so với BN không tăng CA125 (p = 0,001).

Kết luận: Phần lớn BN UTBMBT tái phát tăng CA125 khi bệnh được chẩn đoán (74,6%) với nồng độ CA125 rất dao động. Tăng nồng độ CA125 ở BN UTBMBT tái phát liên quan đến nồng độ CA125 trước điều trị lần đầu và phương pháp điều trị của ung thư tái phát.
Thai chậm tăng trưởng trong tử cung: cập nhật chẩn đoán và xử trí
Authors: Lê Hoàng , Đặng Tuấn Anh
Published: June 2023

Đánh giá sự phát triển của thai nhi là một trong những mục tiêu quan trọng quản lý thai nghén và chăm sóc trước sinh. Sự phát triển của thai nhi phụ thuộc vào rất nhiều yếu tố, trong đó ba yếu tố được coi là quan trọng nhất các tình trạng từ mẹ, thai nhi và rau thai. Theo Liên đoàn Phụ khoa và Sản khoa Quốc tế (FIGO) năm 2021 thai chậm tăng trưởng trong tử cung (FGR) được định nghĩa là việc thai nhi không đáp ứng được tiềm năng phát triển của nó do một hay nhiều yếu tố bệnh lý gây ra, thường gặp nhất là tình trạng rối loạn chức năng rau thai. Trên toàn thế giới, FGR xảy ra ở 10% các trường hợp mang thai là nguyên nhân hàng đầu gây ra thai chết lưu, tử vong sơ sinh và các bệnh tật ngắn hạn và dài hạn cho trẻ nhỏ. Tuy nhiên, FGR là một vấn đề sản khoa phức tạp với các tiêu chuẩn chẩn đoán khác nhau, tỷ lệ chẩn đoán sớm thấp trong khi các lựa chọn điều trị và phòng ngừa còn rất hạn chế. Mục đích của tổng quan này là cung cấp một bản tóm tắt toàn diện dựa trên các bằng chứng, hướng dẫn của các hiệp hội sản khoa lớn trên thế giới như: ACOG, FIGO, ISUOG, SMFM, đã có để có cách tiếp cận sớm, kế hoạch theo dõi, quản lý tốt các thai kỳ có nguy cơ hoặc FGR, nhằm giảm nguy cơ thai chết lưu, tử vong sơ sinh và bệnh tật liên quan đến tình trạng này. Theo ACOG, FIGO, SMFM thai chậm tăng trưởng trong tử cung được chẩn đoán khi chu vi vòng bụng (AC) và/hoặc ước lượng cân nặng thai (EFW) < bách phân vị thứ 10 theo tuổi thai, FGR được chia làm hai loại là FGR khởi phát sớm < 32 tuần và FGR khởi phát muộn sau 32 tuần, cho đến hiện tại chưa có hướng điều trị FGR mang lại hiệu quả tốt nhất nhưng hướng tiếp cận được nhiều hiệp hội khuyến cáo mang lại hiệu quả tốt đó là chẩn đoán sớm, theo dõi sát và chọn đúng thời điểm để chấm dứt thai kỳ.
Nghiên cứu đặc điểm và kết quả kết thúc chuyển dạ ở các trường hợp chuyển dạ đình trệ tại Khoa Phụ sản, Bệnh viện Trường Đại học Y - Dược Huế
Authors: Cao Ngọc Thành , Phan Thị Thanh Diễm
Published: June 2023

Mục tiêu: Khảo sát các đặc điểm chuyển dạ của các trường hợp chuyển dạ đình trệ tại Khoa Phụ sản, Bệnh viện Trường Đại học Y - Dược Huế và đánh giá kết quả kết thúc chuyển dạ và một số yếu tố liên quan.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 211 sản phụ mang thai đủ tháng, từ 37 tuần 0 ngày đến 41 tuần 6 ngày, theo dõi chuyển dạ có dấu hiệu chuyển dạ đình trệ tại Khoa Phụ Sản, Bệnh viện Trường Đại học Y - Dược Huế từ tháng 5/2021 đến tháng 7/2022. Tiêu chuẩn chọn bệnh là sản phụ mang đơn thai, ngôi đầu, tuổi thai từ 37 tuần. Chuyển dạ đình trệ được chẩn đoán theo Hướng dẫn Quốc gia về các dịch vụ chăm sóc sức khỏe sinh sản của Bộ Y tế năm 2016 và ACOG 2003: ở giai đoạn 1 chuyển dạ: cổ tử cung mở ≥ 4 cm, không tiến triển thêm sau 4 giờ; ở giai đoạn 2 chuyển dạ: ngôi thai không tiến triển thêm sau 1 giờ đối với con rạ và 2 giờ đối với con so. Đường biểu diễn trên biểu đồ chuyển dạ cắt ngang đường báo động.

Kết quả: Tuổi trung bình là 27,9 ± 4,8 tuổi. Mang thai lần đầu chiếm tỷ lệ 78,2%, tuổi thai trung bình là 39,7 ± 0,8 tuần. Chuyển dạ tự nhiên chiếm 84,4%. Trung bình tần số cơn go/10 phút là 2,9 ± 0,7 cơn. Cường độ cơn go nằm trong khoảng từ 50 - 80 mmHg. Biểu hiện đình trệ diễn ra ở thời điểm cổ tử cung mở 4 - 5 cm chiếm tỷ lệ 86,3%. Tỷ lệ mổ lấy thai là 65,4% cao hơn so với tỷ lệ sinh đường âm đạo với 71/211 trường hợp (34,6%). Các yếu tố độc lập có mối liên quan đến mổ lấy thai ở thai phụ chuyển dạ đình trệ bao gồm: có khởi phát chuyển dạ với OR = 3,78 (95% CI: 1,34 - 10,63; p = 0,012) so với chuyển dạ tự nhiên, kiểu thế ngang - sau với OR = 3,63 (95% CI: 1,91 - 6,88; p < 0,001) so với kiểu thế trước. Có 32/211 nhập chăm sóc tại đơn vị sơ sinh chiếm 15,2%; có 27/211 trẻ sơ sinh có biến chứng nhiễm trùng tỷ lệ 12,8%; có 8/211 trẻ sơ sinh có biến chứng suy hô hấp chiếm 3,8% và không có trẻ sơ sinh nào tử vong chu sinh.

Kết luận: Các yếu tố độc lập có mối liên quan đến mổ lấy thai ở thai phụ chuyển dạ đình trệ bao gồm: có khởi phát chuyển dạ, kiểu thế ngang - sau.
On the Convergence of Stochastic Aggregated Gradient Method
Authors: OZTOPRAK TOPKAYA Figen
Published: June 2023

The minimization problem of the sum of a large set of convex functions arises in various applications. Methods such as incremental gradient, stochastic gradient, and aggregated gradient are popular choices for solving those problems as they do not require a full gradient evaluation at every iteration. In this paper, we analyze a generalization of the stochastic aggregated gradient method via an alternative technique based on the convergence of iterative linear systems. The technique provides a short proof for the $O(\kappa^{-1})$ linear convergence rate in the quadratic case. We observe that the technique is rather restrictive for the general case, and can provide weaker results.
Notes about an anti-paraHermitian metric connections
Authors: ZAGANE Abderrahım
Published: June 2023

In the present paper firstly, we introduce classes of anti-paraK\"{a}hler-Codazzi manifolds and we discuss the problem of integrability for almost paracomplex structures on thes manifolds. Secondly, we introduce a new classes of anti-paraHermitian manifolds associated with these anti-paraHermitian metric connections with torsion, we look for the conditions in which it becomes are anti-paraK\"{a}hler manifolds or anti-paraK\"{a}hler-Codazzi manifolds.
Approximately Gamma-Near Rings
Authors: Uçkun Mustafa , Gürbüzcan Mehmet
Published: June 2023

The focus of this work is to introduce approximately gamma-near ring, approximately gamma-ideal and approximately
gamma-near ring of all descriptive approximately cosets. Also, some properties of approximately gamma-near ring and
approximately gamma-ideal were given.
Skew Cyclic Codes over $\mathbb{Z}_{8}+u\mathbb{Z}_{8}+v\mathbb{Z}_{8}$
Authors: ÇALIŞKAN Basri , BALIKÇI Kemal
Published: June 2023

In this paper, we study the skew cyclic codes over the ring $S=\mathbb{Z}_{8}+u\mathbb{Z}_{8}+v\mathbb{Z}_{8}$, where $u^{2}=u$, $v^{2}=v$, $uv=vu=0$. We consider these codes as left $S[x,\theta]$-submodules and use the Gray map on $S$ to obtain the $\mathbb{Z}_{8}$-images. The generator and parity-check matrices of a free $\theta$-cyclic

code of even length over $S$ are determined. Also, these codes are generalized to double skew-cyclic codes. We give some examples using Magma computational algebra system.
New Fractional Operators Including Wright Function in Their Kernels
Authors: ATA Enes , KIYMAZ İ. Onur
Published: June 2023

In this paper, we defined new two-fractional derivative operators with a Wright function in their kernels. We also gave their Laplace and inverse Laplace transforms. Then, we presented some connections between the new fractional operators. Furthermore, as examples, we obtained solutions of differential equations involving new fractional operators. Finally, we examined the relations of the new fractional operators with the fractional operators, which can be found in the literature.
Developing a Comprehensive Reading Test for Undergraduate Students: An LMS-Based Reading Test
Authors:   English Language Education Study Program, Universitas Madako Tolitoli, Central Sulawesi, Indonesia, Marzuki Marzuki , Indrawati Inda ,   English Language Education Study Program, Universitas Madako Tolitoli, Central Sulawesi, Indonesia, Yunus Ismail ,   English Language Education Study Program, Universitas Madako Tolitoli, Central Sulawesi, Indonesia
Published: June 2023

There has been a significant increase in the development of reading assessment methods by educators and researchers. However, very few of these assessments have been integrated into a Learning Management System (LMS) platform, with current LMS usage primarily focused on course content delivery. This research aims to address this gap by developing a comprehensive LMS-based reading test to measure students' reading competence. Additionally, the study seeks to explore students' perspectives on the use of the developed instrument. The development of the instrument followed a Research & Development (R&D) approach using the 4D model, which consists of defining, designing, developing, and disseminating stages. The participants of this study were undergraduate English as a Foreign Language (EFL) students from Universitas Madako Tolitoli. In total, 50 reading test items were successfully developed. Both validity and reliability tests were conducted: the validity test was performed by experts in the field and followed by a pilot test with a small sample of students. The results indicated that the test items were reliable, with a Cronbach's Alpha score of 0.75. However, 6 of the items (12%) were deemed to need improvement or were considered invalid, while the remaining 44 items (88%) were judged to be valid. Students' perceptions of the LMS-based reading test were generally positive across three aspects: usability and accessibility, engagement and motivation, and the impact of the LMS on language learning outcomes. In light of the limitations of the current study, suggestions for improvement were also provided. These will serve to guide future research in this area, with the aim of refining the LMS-based reading test and further enhancing its potential benefits for student learning.
Unilateral High Grade Serous Carcinoma of Right Adnexa –A Case Report
Authors:   Junior Resident, Department of Pathology, Govt. Medical College Thiruvananthapuram, B Dr. Vibimol , Vijayaraghavan Dr. Lila Rani ,   Professor and HOD, Department of Pathology, Govt. Medical College Thiruvananthapuram, Mohan Dr. Pratap ,   Assistant Professor, Department of Pathology, Govt. Medical College Thiruvananthapuram
Published: June 2023

Ovarian carcinomas are the most fatal among malignancies of female reproductive tract. The most prevalent type of ovarian cancer, high grade serous carcinoma, has a complex mechanism of carcinogenesis and a poor outcome. However, in recent years, increasing evidence has suggested that tubal fimbriae lesions may be precursor lesions for ovarian high grade serous carcinoma. Here we report a case of high grade serous carcinoma ovary arising from fallopian tube in a 60 year old post menopausal woman.
The Effect of Intellectual Capital, Firm Size, and Capital Structure on Financial Performance Mediated by Exchange Rate in Personal Care and Household Companies
Authors:   Sekolah Tinggi Ilmu Ekonomi Indonesia (STIESIA) Surabaya, Yuniati Tri , Hartono Hartono ,   Fakultas Ekonomi Universitas Islam Majapahit
Published: June 2023

This study aims to examine the effect of intellectual capital (VAICTM), firm size (Ln(TA)), and capital structure (DER) on financial performance (ROA) mediated by exchange rate in personal care and household companies listed on the Indonesia Stock Exchange (IDX) during the period 2016-2021 with a population of 9 companies. This study uses a comparative causal research type. The sampling technique of this study uses a non-probability sampling method using a saturation sample type, which is formed homogeneously by being selected based on predetermined criteria so that as many as five personal care and household companies for the 2016-2021 period were obtained. This study uses a quantitative data analysis technique to acquire secondary data from the company's financial statements using the SPSS application program version 25. The results of this study show that intellectual capital (VAICTM) has a positive and significant effect on the financial performance of personal care and household companies, the firm size (Ln(TA)) has a positive and significant effect on the financial performance of personal care and household companies, while capital structure (DER) has a negative and insignificant effect on the financial performance of personal care and household companies. Moreover, intellectual capital (VAICTM) mediated by exchange rate has a positive and significant effect on the financial performance of personal care and household companies, the firm size (Ln(TA) mediated by exchange rate has a positive and significant effect on the financial performance of personal care and household companies, while capital structure (DER) mediated by exchange rate has a negative and insignificant effect on the financial performance of personal care and household companies.
EFEKTIVITAS APLIKASI BIOCHAR TEMPURUNG KELAPA PADA MEDIA TANAM TERHADAP PERTUMBUHAN DAN SERAPAN HARA N DI PEMBIBITAN UTAMA KELAPA SAWIT (Elaeis guineensis Jacq.)
Authors: Tarigan Sri Murti , Tifany Zia Aznur  , Rafika Umami
Published: June 2023

This study was conducted to determine the effect of application of coconut shell biochar on planting media on the growth and uptake of leaf and soil nutrients in oil palm main nurseries. To get good and healthy seeds, soil conditioner is also needed to increase land productivity. One of the soil improvement materials is biochar. This research was conducted in the STIPAP Medan experimental garden. This research was conducted for 6 months. Starting in August 2020 - February 2021. This study used a Factorial Randomized Block Design (RAK) method consisting of 9 treatments with 4 replications, so the total sample was 36 seedlings. Parameters observed were seedling height, stem diameter, number of leaves, shoot dry weight, root dry weight and nutrient N content in leaves and soil. The data obtained were analyzed statistically by analysis of variance (ANOVA) with the F test. The results of this study indicate that the application of coconut shell biochar and compound fertilizer in oil palm nurseries can use the best combination dose of 1.8 kg of biochar and 75% compound fertilizer of the dose. The standard gave several significant and very significant effects on stem height, stem diameter, number of leaves, shoot dry weight and root dry weight. And the interaction of coconut shell biochar treatment and compound fertilizer did not significantly affect all observation parameters.