bluuebunny/crossref_metadata_2025 huggingface dataset:
Pendampingan Usaha Kecil dan Menengah Keripik Basreng AW dalam Peningkatan Penjualan dan Efisiensi Produksi
Authors:   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Hadyan Rasil Feryan , Wijaya Hansel ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Charis Elsa Jessica ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Michae Michae ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Mirabel Wijaya Karen ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Jeremia Michael ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Mei Mei Siaw ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Saraswati Dewi ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: April 2022

Community Development Program initiated by Universitas Prasetiya Mulya aims to improve community welfare through the assistance and business development of the partners. In 2019, the Community program was taking place in Cianjur, West Java. One of the business partner assisted and developed in the Community Development 2019 program is the Basreng chips business owned by Kang Wendy. Kang Wendy sells and market the product under a brand called AW Basreng. Kang Wendy encounters some challenges in developing his business due to lack of knowledge and skill in managing a good business. However, the Basreng chips business has the potential to develop and can be sustainable because of the characteristic the Basreng flavor developed by Kang Wendy. Within the 45 days, Kang Wendy and the builder team had made some improvements in the area of operational management, marketing, human resources, and finance. With regards to the improvement, Kang Wendy's most successfully achievement is accelerating the production process time and expanding product marketing through online marketing. The writing of this article aims to provide an overview of the problems that arise in MSME businesses and the corrective steps that can be taken to develop a Basreng business in Cianjur, West Java.
Membangun Positive Brand Image dari Koperasi Sugih Makmur
Authors:   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Christiana Audi , Venny Setyadi Elizabeth ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Purnomo Rafelle ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Setiadi Raymond ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Hidayat Rafi ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Heriyanto Kevin ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Asbi Muhammad ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Iswaldi Ihsan ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: April 2022

As a plenary citizen, the development of humanity is an obligation to every human being. To accomplish our duty to serve the community in the region of Cianjur especially Ciputri Village Sarongge, we as writer did a “live in” program for a month from the 17th of January till the 14th of February 2019. This article is composed to report the potential, problems, and progress of our partner’s business during this year’s community development program. As Builder 023, we were assigned to help develop our partner’s existing business “Koperasi Sugih Makmur” in terms of finance, marketing, and human resource management to minimalize human error risks in the future such as bad cash flow. We also saw an opportunity for another potential business line, henceforth we decided to develop strawberry jam as a new line of product. Existed since 28th February 2019, this new line of product has already gained impro
Faktor-Faktor yang Mempengaruhi Konsumen dalam Pembelian Jajanan Tahu Walik di Kota Cianjur
Authors:   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Augustian Billy , Nadya Jesica Camila ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Enrico Clavens ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Nasri Kimberly ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Wahyu Utami Nabilah ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Hoetama Pedro ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Widjaja Samuel ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Marchalina Leonis ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: April 2022

As time goes, Small Medium Enterprise (SME) has grown so fast, especially at Cianjur. Culinary is well-known as biggest contributor for the SME at Cianjur. PKM is a program that support economic growth at Cianjur, which also raise awareness and sales. There are 4 factors that elevate the SME at Cianjur, which is operation, marketing, financing, and human resource management. This research focus on marketing. This research exists to support the growth of Tahu Walik Si Montogh to become a great business. The rise of Tahu Walik Si Montogh can be achieved by choosing the right segmentation, positioning, and target, which based on consumer behaviour in Cianjur. Branding strategy for Tahu Walik Si Montogh use stimulus response approach, and persuasive communication technique that is also based on segmentation, positioning, and target, which has been defined previously and can be the base of marketing strategy for Tahu Walik Si Montogh. These two strategies are also supported by increasing the product diversification to attract customer in Cianjur.
Interactions of Chitosan-coated Green Synthesized Silver Nanoparticles
using Mentha spicata and Standard Antibiotics against Bacterial
Pathogens
Authors: Andleeb Saiqa , Khan Habib , Nisar Tayba , Latif Zahid , Raja Sadaf Azad , Awan Uzma Azeem , Maqbool Kiran , Khurshid Sadia
Published: April 2022

Background:

Infectious diseases are caused by various multidrug-resistant pathogenic
bacteria and in recent scenarios, nanoparticles have been used as innovative antimicrobial agents.

Aims:

This current research aimed to evaluate the bactericidal effect of chitosan-coated green synthesized
silver nanoparticles using aqueous extract of Mentha spicata (MSaqu) against bacterial
pathogens, i.e., Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Pseudomonas
aeruginosa, Serratia marcescens, Staphylococcus aureus, and Streptococcus pyogenes.

Methods:

Synthesis and characterization of silver nanoparticles (MSAgNPs) were carried out via
atomic absorption spectrometer and Fourier-transform infrared spectroscopy. Agar well and agar
disc diffusion methods were used to assess the antibacterial and synergistic effect of chitosanmediated
biogenic silver nanoparticles and standard antibiotics. Three types of interactions, i.e.,
antagonistic (↓), synergistic (↑), and additive (¥) were observed.

Results:

Synergistic effect was recorded against Pseudomonas aeruginosa (8.5±0.25 mm↑), Serratia
marcescens (19.0±1.0 mm↑), and Klebsiela pneumonia (8.5±0.25 mm↑), an additive effect was
exhibited by Escherichia coli (9.0±0.0 mm¥), Streptococcus pyogenes (10.0±0.0 mm¥), and Staphylococcus
aureus (7.5±0.25 mm↓) and they showed antagonistic effects when chitosan-coated silver
nanoparticles (CLMSAgNPs) were applied compared to chitosan, MSaqu, and MSAgNPs. Interesting
antibacterial results were recorded when chitosan-coated Mentha spicata extract and silver nanoparticles
were applied along with antibiotics. The synergistic effects of chitosan-coated silver
nanoparticles (CLMSAgNPs) + K were recorded against E. coli (14.5±0.25 mm). The synergistic
effects of chitosan-coated silver nanoparticles (CLMSAgNPs) + AML were recorded against E. coli
(5.5±0.0 mm), S. pyogenes (10.0±0.0 mm), K. pneumonia (5.5±0.0 mm), and S. aureus (4.0±0.0
mm). The synergistic effects of chitosan-coated silver nanoparticles (CLMSAgNPs) + NOR were
recorded against E. coli (16.0±0.0 mm), P. aeruginosa (19.0±0.0 mm), S. marcescens (19.5±0.25
mm), S. pyogenes (11.5.0±0.25 mm), K. pneumonia (23.0±0.0 mm), and S. aureus (8.5±0.25 mm).

Conclusions:

Current findings concluded that chitosan-coated biogenic silver nanoparticles have
potential bactericidal effects against infectious pathogens and could be used as forthcoming antibacterial
agents.
Infestation of Rice by Gall Midge Influences Density and Diversity of
Pseudomonas and Wolbachia in the Host Plant Microbiome
Authors: Nair Suresh , Sinha Deepak K. , Gupta Ayushi , Padmakumari Ayyagari P. , Bentur Jagadish S.
Published: April 2022

Background:

The virulence of phytophagous insects is predominantly determined by their
ability to evade or suppress host defense for their survival. The rice gall midge (GM, Orseolia oryzae),
a monophagous pest of rice, elicits a host defense similar to the one elicited upon pathogen attack.
This could be due to the GM feeding behaviour, wherein the GM endosymbionts are transferred to the
host plant via oral secretions, and as a result, the host mounts an appropriate defense response(s) (i.e.,
up-regulation of the salicylic acid pathway) against these endosymbionts.

Methods:

The current study aimed to analyze the microbiome present at the feeding site of GM maggots
to determine the exchange of bacterial species between GM and its host and to elucidate their role
in rice-GM interaction using a next-generation sequencing approach.

Results:

Our results revealed differential representation of the phylum Proteobacteria in the GMinfested
and -uninfested rice tissues. Furthermore, analysis of the species diversity of Pseudomonas
and Wolbachia supergroups at the feeding sites indicated the exchange of bacterial species between
GM and its host upon infestation.

Conclusion:

As rice-GM microbial associations remain relatively unstudied, these findings not only
add to our current understanding of microbe-assisted insect-plant interactions but also provide valuable
insights into how these bacteria drive insect-plant coevolution. Moreover, to the best of our
knowledge, this is the first report analyzing the microbiome of a host plant (rice) at the feeding site of
its insect pest (GM).
Recent Developments in Multi-component Synthesis of Lawsone Derivatives
Authors: Vedula Rajeswar Rao , Penta Santhosh , Varma Rajender S. , Chandrakar Komal , Patel Jeevan Lal , Virendra R. K. , Mahapatra Shayama Prasad
Published: April 2022

Background:

2-Hydroxy-1,4-Naphthoquinone (HNQ; Lawsone) is one of the most
useful and the simplest naturally occurring naphthoquinones and has stimulated a resurgence of
interest in the past decades due to a wide range of pharmacological activities.

Introduction and Method:

This activity has led to the unusually large emphasis being placed
on the design of more efficient multi-component reactions (MCRs) in the synthesis of bioactive
lawsone derivatives.

Results and Conclusion:

This review highlights the recent developments in multi-component
synthesis of biologically relevant naphthoquinone linked and fused heterocyclic derivatives carried
out from 2015 till now.
Triamcinolone as a Potential Inhibitor of SARS-CoV-2 Main Protease and
Cytokine Storm: An In silico Study
Authors: Tripathi Vishwas , Mishra Amaresh , Abul Qais Faizan , Pathak Yamini , Camps Ihosvany
Published: April 2022

Background:

An ongoing global public health concern is the emerging COVID-19 pandemic
triggered by acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mpro, a main protease of SARSCoV-
2, has been established as a potential drug target because of its direct role in viral replication and
ability to infiltrate the multiple host pathways.

Objective:

This research aims to classify new therapeutic drug candidates who may be repositioned for
COVID-19 therapeutics.

Methods:

We have taken similar drug compounds of Dexamethasone and targeted the main protease of
SARS-CoV-2 (Mpro) along with the key molecules involved in the 'cytokine storm.' Further, we did MD
simulations and calculated the molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) on the
active site of the main protease of SARS-CoV-2 (Mpro) and TNF-α, IL-6, & IL-1β to explore the binding
affinity and stability.

Results:

Based on our study outcome, Triamcinolone emerged as the most promising inhibitor of the
main protease of SARS-CoV-2 (Mpro) and the cytokine storm molecules, i.e., TNF-α, IL-6, and IL-1β.

Conclusion:

This research investigates the repositioning of COVID-19 drugs as a new therapeutic
application.
Knowlesi Malaria in Children
Authors: Mohan Kriti , Kumar Manish , Omar Balram Ji
Published: April 2022

The fifth malaria parasite causing human malaria- Plasmodium knowlesi (Pk), is not a newly emergent species but was an undiagnosed species before availability of molecular methods as diagnostic tool and was often confused with morphologically similar human malaria parasite P. malariae or P. falciparum. Now it is well distributed species in South-east Asia especially in Malaysia. Since the year 2004, cases of Pk malaria are continuously being reported in adults. Though adult age, forest related activities and recent visit to forested area are well known factors, but childhood did not remain untouched with this disease. Few researches and reports that are available in literature indicate, though the infection in children is uncomplicated, but this may be attributed to scarcity of data and researches in the field. Even cases of Pk malaria in pregnant women and infants are being reported, so this indicates that the problem is not only confined to well-known factors related to the disease but we should think out of the box and take actions before the disease takes the form of significant health burden on human population as vivax and falciparum species did in the past. With the reports of Pk malaria in pregnancy and early infancy, possibility of congenital and neonatal malaria also can’t be denied of. So more and more researches are needed in future to know the clear picture of Pk malaria in pediatric population. So this review covers the problem status, demographic profile, clinical and hematological features, diagnosis, management and outcome of Pk malaria in children worldwide. This review also discusses the gaps in our knowledge in the field of real problem status, prevention, control, diagnosis and management of Pk malaria pertaining particularly to this age group.
Alterations of the Subchondral Bone in Osteoarthritis: Complying with
Wolff’s Law
Authors: Zhang Nianfei , Ding Ran , Wang Qi , Wang Weiguo
Published: April 2022

Osteoarthritis (OA) is a whole joint disease that is significantly related to abnormal me-chanical loads. Subchondral bone alterations, during the evolution course of OA, are considered a reflection of the adaptation of the bone tissue to mechanical loads. However, some of these altera-tions are taken as a detriment and paradoxical. What are these structure, composition, and mechani-cal property alterations or mechanical functions for are not quite clear. In this review, we discuss the possibility that these alterations are used for maintaining the joint function. With taking exces-sive load as a risk factor and under conditions of articular cartilage gradually lose its thickness and its function of evenly distributing the load on the subchondral bone plate, and applying Poroelastici-ty to bone mechanics; moreover, Boussinesq’s pressure bulb theory and bone optimal design princi-ples are utilized. We found that each subchondral bone alteration has its unique mechanical function in resisting loads and maintaining the joint function, and these alterations comply with both bone optimal design principles and Wolff’s law within a proper range.
The Relationship Between FoxP3 and SOCs3 Gene Expressions and Disease Activity in Rheumatoid Arthritis
Authors: Anani Haneya A. A. , Tawfeik Amany M. , El-dydamoni Omnia A. , Maghraby Hend M. , Elshohat Eman , Seliem Nora , Abou elhassan Hanaa A. , Kassem Eman A.
Published: April 2022

Background:

Immune dysregulation plays an important role in the pathogenesis of
rheumatoid arthritis (RA). The CD4+CD25 high FoxP3+ subset of regulatory T cells plays an essential
role in preventing autoimmunity and maintaining immune homeostasis. Negative regulation
of JAK/STAT signaling is controlled by Suppressor of Cytokine Signaling (SOCs3) proteins. SOCs
is produced at lower levels in RA. Our aim was to evaluate the expressional dysregulation of SOCs3
and FoxP3 genes in RA patients in relation to disease activity.

Methods:

We have recruited 90 patients with RA and 60 healthy controls in case control study.
Whole blood samples were collected from RA patients and healthy subjects. The measurement of
FoxP3 and SOCs3 gene expression was performed by real-time PCR (qPCR).

Results:

Patients with RA had significantly decreased expression levels of FoxP3 and SOCs3 genes
in comparison with controls (P<0.001), in addition to the insignificance correlation of both genes
with disease activity in RA patients.

Conclusion:

FoxP3 and SOCs3 genes showed significant defects in rheumatoid arthritis patients
with no significant difference in disease activity.
Attendance Monitoring System Design Based on Face Segmentation and
Recognition
Authors: Rohini Valaparla , Sobhana Mummaneni , Chowdary Ch Smitha
Published: April 2022

Aim:

The proposed work aim was to monitor real-time attendance using face recognition
in every institutional sector. It is one of the key concerns in every organization.

Background:

Nowadays, most organizations spend a lot of time marking attendance for a large
number of individuals manually. Many technologies like Radio Frequency Identification (RFID)
and biometric systems are introduced to overcome the manual attendance system. when using these
RFID and biometric people need to stand in queue to make their presence.

Objective:

The main objective of the system is to provide an automated attendance system with the
help of face recognition owing to the difficulty in the manual as well as other traditional attendance
systems.

Methods:

The proposed work was done through face recognition using Machine Learning. Face
recognition is a part of biometric characteristic of a human. It was easy to process than other biometric
measurements like fingerprint, iris scan, hand scan, retina scan. The Haarcascade classifier
will detect a face, and the LBPH algorithm will recognize the face. The experiment performs on
the creation of real-time face data.

Results:

Using the web camera connected to the computer, face detection and recognition are performed,
and recognized faces mark as attended. Here, the admin module and teacher modules are
implemented with different functionalities to monitor attendance.

Conclusion:

Experiment results get 94.5% accuracy in face detection and 98.5% accuracy in face
recognition by using the Haarcascade classifier and LBPH algorithm. This application system will
be simple to implement, accurate, and efficient in monitoring attendance in real-time.
In Vivo Anti-inflammatory Activity of the Crude Extract, Fractions, and
Ergosterol Peroxide from Sclerotinia Sclerotiorum
Authors: Santos Mário F.C. , Moreira Marcela A.M. , Maiolini Tatiane C.S. , Dias Danielle F. , Chagas-Paula Daniela A. , Azevedo Luciana , Soares Marisi G.
Published: April 2022

Background:

Sclerotinia sclerotiorum is a phytopathogenic fungus from Sclerotinaceae
family. This fungus parasitizes approximately 400 species of plants of great economic importance,
such as soybean and beans. In this study, the anti-inflammatory properties of extracts, fractions, and
isolated compound ergosterol peroxide were investigated. The hexane fraction and 1 inhibited croton
oil-induced ear edema. In addition, ergosterol peroxide also inhibited neutrophil recruitment in the
myeloperoxidase assay, demonstrating that ergosterol peroxide exerts anti-inflammatory activity, inhibiting
the activity of both COX and LOX pathways. Moreover, these results provide new knowledge
regarding S. sclerotiorum as a source of extracts and bioactive compounds.

Objective::

The present study aimed to investigate the phytochemical profile of Sclerotinia sclerotiorum
and its in vivo anti-inflammatory activity.

Method:

The crude extract, fractions, and ergosterol peroxide of Sclerotinia sclerotiorum were evaluated
by croton oil-induced ear edema quantification of MPO (myeloperoxidase enzyme).

Results:

The crude extract and hexane fraction exhibited edema inhibition of 50.5 and 70.6%, respectively.
The ergosterol peroxide isolated from the hexane bioactive fractions exhibited significant inhibition
of ear edema, indicating inhibition of the COX pathway. In addition, ergosterol peroxide inhibited
neutrophil recruitment.

Conclusion:

The extract and fractions, as well as the isolated compound of Sclerotinia sclerotiorum,
exhibited anti-inflammatory potential.
Performance Enhancement of FSO System using Modified Exponentiated
Weibull Channel Model
Authors: Pradhan Himansu Shekhar
Published: April 2022

Background:

In free space optics (FSO) communication system, turbulence in the atmosphere
leads to the intensity fluctuations of the received signal at the receiver end. Due to this reason,
the performance of the free space optical communication system gets affected and results in fading of
the received signal.

Objectives:

Performance improvement of FSO system using sophisticated channel modelling and fading
mitigation techniques.

Methods:

This paper presents the performance improvement of the FSO system using a modified Exponentiated
Weibull (MEW) channel model. Moreover, the performance of the FSO system is compared
using different channel models such as Gamma-Gamma and Exponentiated Weibull.

Results:

The results in bit error rate (BER) with respect to different signal to noise ratio (SNR) are obtained
using MEW, Gamma-Gamma, and Exponentiated Weibull channel models. In addition, BER is
calculated for different aperture sizes such as 1.8, 5, and 13 mm using the proposed channel model to
improve the performance of the FSO system. Similarly, the relay assisted technique is utilized to calculate
the BER using the proposed channel model.

Conclusion:

An improvement of free space optical communication system is presented in terms of
fading using channel modelling at different atmospheric turbulence conditions. An appropriate
channel model is proposed for improving the performance of the FSO communication system using
fading mitigation techniques. The proposed MEW channel model best describes the strong atmospheric
turbulence induced fading. In addition, the performance of the free space optics system is improved
using fading mitigation techniques such as aperture averaging and relay assisted FSO system.
Belzutifan: A Narrative Drug Review
Authors: Visweswaran Vysakh , Pavithran Keechilat
Published: April 2022

Von Hippel-Lindau disease is an autosomal dominant disorder characterised by renal
cell carcinomas, pancreatic neuroendocrine tumours, central nervous system hemangioblastomas,
retinoblastomas, and tumours of the reproductive tract. This disease results from loss of function
mutations in the tumour suppressor gene known as the Von Hippel-Lindau gene, located on
chromosome 3. Loss of function mutation in the Von Hippel-Lindau gene results in the
accumulation of a protein known as a hypoxia-inducible factor, which promotes cellular
proliferation and angiogenesis, leading to cancer. Belzutifan inhibits the hypoxia-inducible factor
by binding to the Per-ARNT -Sim-B binding pocket on the hypoxia-inducible factor -2α, inhibiting
cellular proliferation and angiogenesis. In our thorough literature review, we identified 37 relevant
articles. Belzutifan showed clinically meaningful response rates for both Von Hippel-Lindau
disease-associated renal cell carcinomas and non-renal cell cancers. The pharmacokinetic profile
of belzutifan was much better than its congener molecules due to the optimisation of its dihalide
groups from germinal to vicinal. The pharmacodynamic effect of belzutifan was confirmed by its
ability to decrease serum erythropoietin, which is a direct result of hypoxia-inducible factor- 2α
inhibition. The significant side effects observed were anaemia, hypoxia, fatigue, hypertension,
visual impairment and weight gain. Multiple clinical trials are currently underway to determine the
role of beluztifan as part of combination regimens in treating Von Hippel-Lindau diseaseassociated
malignancies.
Public Attitude to Urban Public Transportation Services in Jember, Indonesia
Authors: Kriswardhana Willy , Hayati Nunung , Kusdiyanto Achmad
Published: April 2022

In this current condition, people’s interest in using public transportation in Jember is decreasing with a low load factor value below 50%. It can be caused by the quality of services provided by service providers to the satisfaction of public transport users. Importance-Performance Analysis (IPA) method is used to determine the level of satisfaction of public transport users in Jember District. The satisfaction level of public transport users is obtained from several attributes that belong to the Cartesian diagram. The attributes that need improvement are the punctuality of the services, providing a sense of security and comfort and first aid facilities. The user's willingness to pay is Rp.4,000.00 - Rp.5,000.00. Directions for future studies are presented
Faktor-faktor yang Mempengaruhi Kesuksesan Sistem Informasi Remunerasi pada Fakultas Teknik Universitas Brawijaya Malang)
Authors: Afifah Indah Nurul , Suryadi Suryadi , Nuh Mohammad
Published: April 2022

Universities have implemented many information systems that can facilitate the work of users but need to be considered to address the problems faced. Remuneration Information System at Brawijaya University has often been improved, both from the user side of the application and from the application system itself. The purpose of this study is to find out what factors affect the Net Benefits of Remuneration Information System (Study at the Faculty of Engineering Universitas Brawijaya Malang) using the theory of DeLone &McLean 2003. Hypothesis testing formulated in this study uses Partial Least Squares (PLS). The result of this study is that there are seven factors that affect the net benefits of Remuneration Information System, namely: System Quality against User Satisfaction, Quality of Information against Use, Quality of Information on User Satisfaction, Quality of Service to Use, Quality of Service to User Satisfaction, User Satisfaction against Use, User Satisfaction to Net Benefits. The quality of the System on Remuneration Information System has not been good so its use is still low and the use in remuneration information systems is still low so that the Net Benefit is still low.
Model Perencanaan Sumber Daya Manusia di BKD Provinsi Jawa Timur: Sebuah Tantangan Menghadapi Pandemic Covid 19
Authors: Mahmudin M Nur Kharis , Hermawan Hermawan , Hanafi Imam
Published: April 2022

Planning for employee needs at BKD East Java Province has an important role because it is related to getting the right employees, in the right number, with the right capabilities, at the right time, and in the right place to achieve organizational goals both in the short and long term. The problem is the unequal capacity of OPD employees in aligning the direction determined by the Central Government and there are advantages and disadvantages of employees in the organization. The purpose of this study was to identify and describe the planning model for employee needs in the BKD of East Java Province in dealing with the Covid-19 pandemic, both in terms of the process and the reasons. The results of the study show that the BKD of East Java Province innovated changes in the needs planning process by coordinating and aligning the network (online) to deal with the Covid-19 pandemic. This is done as a way to ensure that the planning carried out can provide accuracy for OPD in terms of quantity and quality. It is necessary to increase the internal capacity of the OPD in order to create a good planning for the needs of employees in the Regional Government.
Covid-19 Information on Instagram: Reception Analysis towards Indonesian Youth Audiences
Authors:   Universitas Gadjah Mada, Purwaningtyas Mashita Phitaloka Fandia , Widihastuty Louisa Diandra
Published: April 2022

Instagram social media platform has become the source of recent information on various fields for the youth audiences, including the ongoing Covid-19 pandemic that Indonesia and the world are currently facing. Unfortunately, not every information on Instagram, especially the controversial and viral ones, are aimed to be informative. Some information is considered provocative and only creating panic instead of raising awareness. This research is intended to understand how Indonesian youth audiences perceive Covid-19 related information through Instagram and how useful and informative the information has been. The research is conducted using a qualitative approach and reception analysis method by interviewing the informants to achieve specific data. All informants are categorized as youth audiences with different socio-cultural backgrounds. Findings in this research show that informants tend to be in the negotiated reading position, in which they are negotiating the Covid-19 information they gain from Instagram with the discourse that they may receive from other sources. They believe that Covid-19 is real, but they have concerns in regards to the handling effort of the virus spread in Indonesia. This negotiated position has evoked both fear and alertness among Indonesian youth towards the uncertainty condition of this pandemic era.
Children With Medical Complexity in the Canadian Maritimes: Protocol for a Mixed Methods Study
Authors: Breneol Sydney , Curran Janet A , Macdonald Marilyn , Montelpare William , Stewart Samuel A , Martin-Misener Ruth , Vine Jocelyn
Published: April 2022

Background

Ongoing developments in the medical field have improved survival rates and long-term management of children with complex chronic health conditions. While the number of children with medical complexity is small, they use a significant amount of health resources across various health settings and sectors. Research to date exploring this pediatric population has relied primarily on quantitative or qualitative data alone, leaving significant gaps in our understanding of this population.

Objective

The objective of this research is to use health administrative and family-reported data to gain an in-depth understanding of patterns of health resource use and health care needs of children with medical complexity and their families in the Canadian Maritimes.

Methods

An explanatory sequential mixed methods design will be used to achieve our research objective. Phase 1 of this research will leverage the use of health administrative data to examine the prevalence and health service use of children with medical complexity. Phase 2 will use case study methods to collect multiple sources of family-reported data to generate a greater understanding of their experiences, health resource use, and health care needs. Two cases will be developed in each of the 3 provinces. Cases will be developed through semistructured interviews with families and their health care providers and health resource journaling. Findings will be triangulated from phase 1 and 2 using a joint display table to visually depict the convergence and divergence between the quantitative and qualitative findings. This triangulation will result in a comprehensive and in-depth understanding into the population of children with medical complexity.

Results

This study will be completed in May 2022. Findings from each phase of the research and integration of the two will be reported in full in 2022.

Conclusions

There is a current disconnect between the Canadian health care system and the needs of children with medical complexity and their families. By combining health administrative and family-reported data, this study will unveil critical information about children with medical complexity and their families to more efficiently and effectively meet their health care needs. Results from this research will be the first step in designing patient-oriented health policies and programs to improve the health care experiences, health system use, and health outcomes of children with medical complexity and their families.

International Registered Report Identifier (IRRID)

DERR1-10.2196/33426
Children With Medical Complexity in the Canadian Maritimes: Protocol for a Mixed Methods Study (Preprint)
Authors: Breneol Sydney , Curran Janet A , Macdonald Marilyn , Montelpare William , Stewart Samuel A , Martin-Misener Ruth , Vine Jocelyn
Published: April 2022

BACKGROUND

Ongoing developments in the medical field have improved survival rates and long-term management of children with complex chronic health conditions. While the number of children with medical complexity is small, they use a significant amount of health resources across various health settings and sectors. Research to date exploring this pediatric population has relied primarily on quantitative or qualitative data alone, leaving significant gaps in our understanding of this population.

OBJECTIVE

The objective of this research is to use health administrative and family-reported data to gain an in-depth understanding of patterns of health resource use and health care needs of children with medical complexity and their families in the Canadian Maritimes.

METHODS

An explanatory sequential mixed methods design will be used to achieve our research objective. Phase 1 of this research will leverage the use of health administrative data to examine the prevalence and health service use of children with medical complexity. Phase 2 will use case study methods to collect multiple sources of family-reported data to generate a greater understanding of their experiences, health resource use, and health care needs. Two cases will be developed in each of the 3 provinces. Cases will be developed through semistructured interviews with families and their health care providers and health resource journaling. Findings will be triangulated from phase 1 and 2 using a joint display table to visually depict the convergence and divergence between the quantitative and qualitative findings. This triangulation will result in a comprehensive and in-depth understanding into the population of children with medical complexity.

RESULTS

This study will be completed in May 2022. Findings from each phase of the research and integration of the two will be reported in full in 2022.

CONCLUSIONS

There is a current disconnect between the Canadian health care system and the needs of children with medical complexity and their families. By combining health administrative and family-reported data, this study will unveil critical information about children with medical complexity and their families to more efficiently and effectively meet their health care needs. Results from this research will be the first step in designing patient-oriented health policies and programs to improve the health care experiences, health system use, and health outcomes of children with medical complexity and their families.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/33426
Peer Review of “The Association of Shared Care Networks With 30-Day Heart Failure Excessive Hospital Readmissions: Longitudinal Observational Study” (Preprint)
Authors: Zhao Peng
Published: April 2022

UNSTRUCTURED

This is a peer review report related to ms# 30777.
From the Cochrane Library: Interventions for Preventing Occupational Irritant Hand Dermatitis (Preprint)
Authors: Abdel Azim Sara , Vecerek Natalia , Ortega-Loayza Alex G , Bauer Andrea , Adler Brandon L
Published: April 2022

UNSTRUCTURED

N/A
COMPARISON OF PUBLIC'S INTEREST IN SELECTING TRADITIONAL AND MODERN MEDICINE THERAPY
Authors: FITRIAH RAHMAYANTI , HIDAYATI RAHMI , MUTHIA REZKY HENY
Published: April 2022

Objective: This study aims to determine the public's interest in selecting traditional medicine or modern medicine and the factors that influence this interest in Loktabat Selatan Village, Banjarbaru City, South Kalimantan Province, Indonesia.

Methods: The research method used a Cross-Sectional approach. The data were collected from 100 respondents of Loktabat Selatan Village people, Banjarbaru City, using an instrument in questionnaire form.

Results: The comparison result of the interest of the therapy choice showed in traditional medicine interest was 58%, and modern medicine was 42%. For the comparison of respondents' interests results based on internal factors were 55.2% which was a decent category, and external factors were 53.4% which was enough category. Data analysis using the Chi-Square test obtained a sig value of 0.814>0.05, then H0 is accepted.

Conclusion: There is a comparison of public interest in selecting of traditional and modern medicine therapy in South Loktabat Village, Banjabaru City, South Kalimantan Indonesia.
EFFECT OF VANILLIN QUALITY ON THE SYNTHESIS AND SOLID DISPERSION SYSTEMS ON PGV-0 ANTIOXIDANT CAPACITY
Authors: RAMADHAN HAFIZ , FORESTRYANA DYERA , ADISAPUTRA GUSTI TIRTA , MUHARRAM SITI RAHMAH
Published: April 2022

Objective: Pentagamavunon-0 (PGV-0) was a curcumin analog with antioxidant properties and has been synthesizing with improvement techniques using vanillins with different qualities. PGV-0 has a low bioavailability but could be increased solubility by making a solid dispersion system. This study aimed to determine the antioxidant properties of PGV-0 that were synthesized with different quality starting materials of vanillin and also to obtain the effect of PEG 6000 and maltodextrin solid dispersion systems.

Methods: PGV-0 was synthesizing by mixing cyclopentanone into two different groups of vanillins (vanillin pro analysis and vanillin “Kapal Layar”) using an HCl catalyst. The purity of products was identified with TLC (Thin Layer Chromatography) and spectrophotometrically compared with PGV-0 standard. Solid dispersion system consisting of two treatment groups: PEG 6000 and maltodextrin groups. The measurement of antioxidant properties was examined by Cupric Ion Reducing Antioxidant Capacity (CUPRAC).

Results: PGV-0 of vanillin pro analysis group (EC50= 13.62 ppm) was found higher antioxidant capacity as compared to the vanillin “Kapal Layar” group (EC50= 15.35 ppm). The solid dispersion system of PGV-0-PEG 6000 at ratio 1:10 has shown powerful antioxidant capacity (EC50= 9.00 ppm) than the PGV-0-PEG 6000 at ratio 1:5 group (EC50= 10.65 ppm). PGV-0-maltodextrin at ratio 1:10 (EC50= 11.96 ppm) also has powerful antioxidant activity when compared with PGV-0-maltodextrin at ratio 1:5 (EC50= 13.63 ppm).

Conclusion: The results of the study showed that the use of vanillin with different qualities in PGV-0 synthesis and also solid dispersion systems can affect the antioxidant activity of PGV-0.
INTENSIVE MONITROING OF SINOVAC VACCINE FOR SAFETY AND EFFICACY AMONG INDONESIAN POPULATION
Authors: KEZIA VALERIE , RAMATILLAH DIANA LAILA
Published: April 2022

Objective: To Evaluate intensively patients taking Sinovac-CoronaVac vaccine for the side effects and effectiveness in preventing COVID infection.

Methods: This is a prospective crossectional study using convenience sampling for all Indonesian populations who received full dose of Sinovac-CoronaVac vaccine.

Results: The efficacy and safety of the Sinovac-CoronaVac vaccine is 96.8%. factors that influence efficacy and safety are side effects with Age, BMI and Gender with p-value<0.05.

Conclusion: There is correlation between side effects of Sinovac-CoronaVac with Age, BMI and Gender for safety and efficacy.
MOLECULAR DOCKING STUDY ON PHYTOCONSTITUENTS OF TRADITIONAL AYURVEDIC DRUG TULSI (OCIMUM SANCTUM LINN.) AGAINST COVID-19 MPRO ENZYME: AN IN SILICO STUDY
Authors: JAIN NEM KUMAR , AGRAWAL ANURAG , KULKARNI GIRIRAJ T. , TAILANG MUKUL
Published: April 2022

Objective: The aim of the present study was to assess bioactive compounds found in Tulsi as potential COVID-19 Mpr °inhibitor using molecular docking and to provide scientific justification in term of its active ingredient to target protein for prevention and symptomatic treatment of COVID-19.
Methods: COVID-19 Mpr °was docked with eight phytochemicals of Ocimum sanctum Linn. Using Autodock 4.2. Determination of active site and visualization of molecular interactions between ligands and target enzyme was done by Biovia Discovery Studio 4.5.
Results: Our result demonstrates that Vicenin, Caryophyllene, Cirsimaritin, Isothymusin and Isothymonin have a better binding affinity to target enzyme. However, only Vicenin exhibited better binding energy i.e.-7.02 kcal/mol to COVID-19 Main protease among other phytochemicals through some responsible interactions to inhibit the replication of SARS-CoV-2 in the human body, whereas Caryophyllene and Cirsimaritin exhibited similar binding affinity i.e.-6.46 kcal/mol but different interactions with target enzyme.
Conclusion: Tulsi (Ocimum sanctum Linn.) is a preeminent traditional drug of Ayurveda for prophylaxis and treatment of various ailments, including respiratory disorders like cough, cold and flu. With no specific therapies available, reevaluating and repurposing traditional drugs could be an effective approach for the prevention and treatment of SARS-CoV-2 infection. Therefore our study provides scientific evidence for the potential use of Tulsi as an adjunct therapy for the prevention and symptomatic treatment of COVID-19. However, further in vitro and in vivo studies should be conducted to validate use of proposed compounds in drug discovery and as therapeutics against COVID-19.
O VIŠESTRANAČJU KOD SRBA -POLITIKOLOŠKO-ISTORIJSKI ASPEKT-
Authors: Subotic Momcilo
Published: April 2022

Ovaj članak je pisan povodom 30 godina od obnavljanja višepartijskog sistema u Srbiji. Autor je mišljenja da je bilo potrebno da se napravi istorijski pregled, tj. politikološko-istorijski presek višestranačja u Srbiji, kao i u drugim delovima bivše jugoslovenske države u kojima je živeo i politički delovao srpski narod, u predjugoslovenskom, jugoslovenskom i postjugoslovenskom periodu, odnosno u samostalnoj Srbiji. Pored periodizacije višestranačkog sistema u Srbiji-Jugoslaviji-Srbiji, prezentovani su ključni istorijski i politički momenti Srba, političkih stranaka i njihovih vođa, preko kojih su artikulisana sva važna nacionalna, politička i državna pitanja srpske i jugoslovenske države. U radu je korišćen istorijski metod, zatim metod analize i sinteze, pogotovo imajući u vidu da se razmatra dugačak istorijski period: od nastanka prvih političkih stranaka u Srbiji – druga polovina 19. veka – do kraja 20. veka. Naučni i društveni cilj ovog rada su povezani i uzajamno isprepleteni: cilj je da se sagledaju učinci višestranačja na srpskom državnom i političkom prostoru u trajanju više od jednog veka, i da se povuku neke paralele u ponašanju i delovanju srpskih političara i partija u prošlosti i danas.
Working Paper PUEAA No. 7. Development of a farm robot (Voltan)
Authors:   Universidad Autónoma de Chapingo, Velázquez López Noé
Published: April 2022

Over the last century, agriculture has evolved from a labor-intensive industry to one that uses mechanized, high-powered production systems. The introduction of robotic technology in agriculture could be a new step towards labor productivity. By mimicking or extending human skills, robots overcome critical human limitations, including the ability to operate in harsh agricultural environments. In this context, in 2014 the development of the first agricultural robot in Mexico (“Voltan”) began at Chapingo Autonomous University. The research’s objective was to develop an autonomous multitasking vehicle for agricultural work. As a result of this development, a novel suspension system was created. In addition, autonomous navigation between crop rows was achieved through computer vision, allowing crop monitoring, fertilizer application and, in general, pest and disease control.
Working Paper PUEAA No. 10. Japanese Investment in Mexico: Challenges for the 2020 Decade
Authors:   Programa Universitario de Estudios sobre Asia y África, UNAM, De la Veha Shiota González Vania
Published: April 2022

Japanese investment is essential for Mexico not just because it has represented a viable economic diversification option, but the investments have been made in one of the most significant Gross Domestic Product (GDP) contributing industries. Moreover, it is very prestigious, and it has managed to attach itself to local and global companies which, especially in the Bajío region, consolidate local and regional production networks. One of the features that contribute to the good prestige of Japanese investment is, without a doubt, its capacity to plan for the short, medium and long-term. That means challenges such as government and technological changes are factors that both Japanese firms and different government levels take into consideration to make decisions. In this context, this article aims to reflect on the course of Japanese investment in Mexico for the 2020 years, taking into account its historical background, its current state and the international context.