bluuebunny/crossref_metadata_2025 huggingface dataset:
BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression
Authors: Chen Ceshi , Kong Yanjie , Lan Tianlong , Wang Luzhen , Huang Haihui , Lv Wenxing , Zhou Chengang , Sun Xiuyun , Weng Xin , Cai Chang , Peng Wenfeng , Zhang Meng , Jiang Dewei , Yang Chuanyu , Liu Xia , Rao Yu
Published: January 2024

Interest in the use of proteolysis-targeting chimeras (PROTACs) in cancer therapy has increased in recent years. Targeting bromodomain and extra terminal domain (BET) proteins, especially bromodomain-containing protein 4 (BRD4), has shown inhibitory effects on basal-like breast cancer (BLBC). However, the bioavailability of BRD4 PROTACs is restricted by their non-selective biodegradabilityand low tumor-targeting ability. We demonstrated that 6b (BRD4 PROTAC) suppresses BLBC cell growth by targeting BRD4, but not BRD2 and BRD3, for cereblon (CRBN)-mediated ubiquitination and proteasomal degradation. Compound 6b also inhibited expression of Krüppel-like factor 5 (KLF5) transcription factor, a key oncoprotein in BLBC, controlled by BRD4-mediated super-enhancers. Moreover, 6b inhibited HCC1806 tumor growth in a xenograft mouse model. The combination of 6b and KLF5 inhibitors showed additive effects on BLBC. These results suggest that BRD4-specific PROTAC can effectively inhibit BLBC by downregulating KLF5, and that 6b has potential as a novel therapeutic drug for BLBC.
Studies on Intersubgeneric Hybridization ability between Evergreen Rhododendron varieties and native Rhododendron decorum Franch.
Authors: Hao Ziyao , Guan Wenling , Yang Yingying , Song Jie , Meng Jing , Li Yefang
Published: January 2024

The horticultural varieties of the evergreen Rhododendron 'Sima,' 'Yin Taohong' and 'Little Taohong' were used as the maternal lines, and the wild Rhododendron decorum Franch. was used as the paternal line for intergeneric crosses. Moreover, the horticultural varieties within the evergreen Rhododendron were also used as controls to study the effect of different pollination methods on hybrid compatibility. After the pollination, the rates of ovary swelling and fruit bearing, numbers of capsule seed, 1,000 seed weight of hybrid seeds, and the rates of germination and green seedlings were examined to comprehensively evaluate the degree of hybrid ability. Simultaneously, the pollen tube growth, fertilization, and hybrid embryo growth and development through the pollen tube were observed by fluorescence microscopy and paraffin sectioning to study the compatibility and histological mechanism of intersubgeneric hybridization between horticultural varieties of the evergreen Rhododendron and Rhododendron decorum Franch. This study provided a scientific basis for intergeneric hybridization breeding between the evergreen Rhododendron and the Rhododendron decorum Franch..
Multi-photon 3-Stage QKD for Practical Quantum Networks
Authors: Jha Nitin , Parakh Abhishek , Subramaniam Mahadevan
Published: January 2024

Quantum key distribution (QKD) will most likely be an integral part of any practical quantum network setup in the future. However, not all QKD protocols can be used in today's networks because of the lack of single photon emitters and noisy intermediate quantum hardware. Attenuated photon transmission typically used to simulate single photon emitters severely limits the achievable transmission distances and the integration of QKD into existing classical networks that use tens of thousands of photons per bit of transmission. Furthermore, it has been found that different protocols perform differently in different network topologies. In order to remove the reliance of QKD on single photon emitters and increase transmission distances, it is worthwhile exploring QKD protocols that do not rely on single-photon transmissions for security, such as the 3-stage QKD protocol; the 3-stage protocol can tolerate multiple photons in each burst without leakage of information. This paper compares and contrasts the 3-stage QKD protocol and its efficiency in different network topologies and conditions. Further, we establish a mathematical relationship between achievable key rates for increasing transmission distances in various topologies. Our results provide insight to a network engineer in designing QKD networks of the future.
Excavation-induced damage zoning of the underground powerhouse with high geostress based on multiple monitoring methods.
Authors: Dong Linlu , Xu Nuwen , Xiao Peiwei , Li Biao , Li Peng , Li Yonghong , Zhao Tieshuan
Published: January 2024

The primary factor restricting the construction of deeply buried underground projects is the imprecise identification of the surrounding rock damage zone. This study examines the Shuangjiangkou underground powerhouse to investigate damage zoning in the surrounding rock mass. The temporal and spatial characteristics of deep rock mass deformation evolution are studied by multipoint extensometers, microseismic (MS) monitoring, acoustic wave testing and borehole TV. Subsequently, a quantitative analysis delineating damage zones is executed by evaluating alterations in displacement, wave velocity volatility, and the distribution of MS events within the surrounding rock mass. The excavation zone of the surrounding rock mass is segmented into distinct sectors: highly-damaged zones (HDZs), excavation-damaged zones (EDZs) and excavation-disturbed zones (EdZs). Additionally, the energy ratio of S-waves to P-waves (Es/Ep) and the moment tensor inversion (MTI) are introduced to reveal the failure mechanism of the surrounding rock mass in each damage zone. The results show that the rock mass fracture around the Shuangjiangkou underground powerhouse presents remarkable zonation characteristics. The spatial depth ranges for the HDZs, EDZs, and EdZs, determined quantitatively based on multivariate monitoring data, are 0–5 m, 5–10 m, and 10–20 m, respectively. The failure mechanisms of surrounding rock mass differ across various damage zones: the HDZ primarily exhibits tensile failure, while the EDZ is mainly characterized by shear failure. The research provides a valuable reference for evaluating the stability of surrounding rock during the excavation of underground caverns of Shuangjiangkou hydropower station.
A novel lattice model considering traffic flow gradient estimation information on curved road in CPS environment
Authors: Kang Yi-Rong , Tian Chuan
Published: January 2024

In order to explore the mechanism that a driver’s anticipation effect in cyber-physical systems (CPS) environment has on the traffic flow on a curved road, a parameter for flow gradient is introduced to characterize the driver's anticipation of the variation trend of traffic flow on curved road ahead. On this basis, combined with the mechanical characteristics of curved road, an improved lattice model for curved road is proposed. The effect of anticipation information of flow gradient on the stability of traffic flow on curved road is analyzed by linear stability theory, and corresponding stability criterion is obtained. Through the perturbation reduction method, the spatiotemporal evolution mechanisms of traffic congestion in the stable flow region, unstable region, and metastable region of the curved road traffic flow were explored, and corresponding descriptive equations and density wave solutions were obtained. Numerical simulations were conducted to validate the theoretical analysis of the model, and the results indicated that the stability of the macroscopic traffic flow in the curve increased with the increase of road radian under the condition of the same initial density. Furthermore, the effect of the traffic gradient estimation information enhanced the control stability and alleviated traffic congestion in curved road traffic flow.
AI-Driven Aging Pattern Analysis for Improving 0.2% Proof Stress in Binary Ni-Al Alloys with γ – γ' Two-Phase Structure
Authors: Nandal Vickey , Dieb Sae , Bulgarevich Dmitry S. , Osada Toshio , Koyama Toshiyuki , Minamoto Satoshi , Demura Masahiko
Published: January 2024

This study presents the comprehensive analysis of flexible non-isothermal aging (NIA) patterns discovered through artificial intelligence (AI) to improve the mechanical strength (0.2% proof stress) in γ – γ' two-phase, binary Ni-Al alloys. In our recent investigation, we found that the AI algorithm could propose aging patterns with superior strength compared to conventional isothermal aging. In this current study, we continued our extensive exploration of AI methodologies, uncovering diverse patterns that also surpassed the isothermal aging benchmark. Remarkably, out of 2823 NIA schedules, we found 173 ones outperforming the isothermal aging benchmark. Furthermore, we conducted a detailed analysis of newly AI-discovered patterns. We identified two critical factors for strength improvement: exposure at 700 ℃ and the number of consecutive 700 ℃ exposures (optimally set at two), alongside non-consecutive steps (up to five). The insights gained from these findings may demonstrate the potential of AI-driven approaches to yield ideas on how to achieve improved strength in Ni-Al alloys.
Increasing the Output Power of Two-Stroke Pulse Sharpeners Based on Step Recovery Diodes
Authors:   Tomsk State University of Control Systems and Radioelectronics, Semyonov Edward V. , Pozdnyakov Vladislav S. ,   Institute of High Current Electronics, Siberian Branch of the Russian Academy of Sciences, Poltorykhin Kirill M. ,   Institute of High Current Electronics, Siberian Branch of the Russian Academy of Sciences, Berezin Andrey A. ,   Institute of High Current Electronics, Siberian Branch of the Russian Academy of Science
Published: January 2024

The proposed two-stroke pulse sharpeners have a relatively low output power (1.5 W). This limits the use of such sharpeners for their intended purpose: for observing small nonlinear ultrawideband responses from objects in diagnostic, measuring and radar systems. In the article an approach to increase the output power of a sharpener is considered. At this approach the output pulse is created not by discharging the capacitance to the load, but by switching the current flowing through an inductive energy storage to the load. When the voltages in the circuit are limited (by bias sources), energy storage in the current form makes it possible to increase the output power of the sharpener to 3.4 W, and the slew rate of the output voltage from 34 to 46 V/ns.
Forest fires detection based on image processing obtained using UAV
Authors:   Tomsk State University of Control Systems and Radioelectronics, Kataev Mikhail Yu. , Kartashov Evgeny Yu. ,   Seversk Technological Institute, National Research Nuclear University «MEPhI», Geiko Pavel P. ,   Institute of monitoring climatic and ecological systems SB RAS, Department optoelectronic systems and remote sensing (OESiRS), National Research Tomsk State University
Published: January 2024

Forest fires represent a serious natural risk causing economic losses, loss of life and significant environmental damage. In different countries of the world, including in Russia, research has been carried out to develop solutions for the detection and subsequent monitoring of forest fires. The most common ones are remote fire detection and monitoring systems, both groundbased (mobile or stationary), airborne (airplanes and helicopters), and satellite-based ones. These systems are highly efficient in data collection and fire detection, but for small areas. However, wildfires can cover large areas, making known approaches unsuitable for optimal spatial coverage. To overcome this limitation, unmanned aerial vehicles (UAVs) are proposed, that have proven to be useful due to their maneuverability, allowing the implementation of remote information acquisition in any direction, the flight route planning strategies, etc. Ultimately, they provide a low-cost alternative to established approaches for real-time detection and monitoring of wildfire areas. This article discusses a technique for early detection of forest fires based on UAV image processing, which is based on the previous works of the authors. The technique involves the use of computer vision algorithms for processing images received from an unmanned motor glider (UMG). The UMG route (for example, circular or elliptical) can be designed in such a way that it is possible to regularly receive information about a large area. The flight time of the UMG can be up to several hours. When transmitting the received images to the processing center, it becomes possible to extract information about the detection of a forest fire and subsequently control its spread.
A study on the feature preservation relationship between aspiration and glottalization of voiceless alveolar stop in English
Authors:   British And American Language And Literature Association Of Korea, Choi Youngyi
Published: January 2024

This study is to argue that the choice between aspiration and glottalization of /t/ by speakers in the same phonological environment can be influenced by differences in the ranking of feature preservation constraints. Besides, I propose that if Korean learners of English tend to produce aspiration in environments where glottalization are prevalent, it results from applying the constraint favoring listener's perceptive ease being ranked higher than that favoring speaker's articulatory ease. Allophones of /t/ can vary even among native speakers due to different sociolinguistic factors. When Korean learners of English apply the constraint of [aspirated] feature preservation at a high ranking, with the intention of enhancing listener's perception, pronunciation errors may occur. Also, if they rank high the constraint for avoiding consonant cluster, which is not allowed in Korean language, they can produce awkward pronunciation. Therefore, by analyzing aspiration and glottalization of /t/ through Optimality Theory, this paper aims to demonstrate that the reason English /t/ exhibits more phonological variants and allophones is attributed to the low feature preservation it holds.
An Analysis of Satire and Schema in Alice’s Adventures in Wonderland
Authors:   British And American Language And Literature Association Of Korea, Kim Damsil
Published: January 2024

This paper adopts a stylistic approach, drawing on schema theory, to unravel Lewis Carroll’s use of characters and parodies as instruments of satire aimed at adult society. Carroll subverts readers’ schemata by infusing creatures in Alice’s Adventures in Wonderland with behaviors and language incongruent with conventional norms. Satire happens when schema is challenged or disrupted. Examining the alignment and subversion of readers’ schemata regarding adult behavior in Alice’s Adventures in Wonderland, this paper intends to provide examples of interplay between schema theory and literary satire in Carroll’s iconic work. It will thus contribute to our understanding of the cultural significance and Carroll’s satirical views embedded in Alice’s Adventures in Wonderland.
INCREASING DRONES’ COMBAT EFFECTIVENESS: AN ALTERNATIVE ANALYSIS FOR INTEGRATION INTO COMPREHENSIVE MILITARY AND TECHNOLOGICAL SYSTEMS
Authors: TUNA Fatih
Published: January 2024

While the use of armed unmanned aerial vehicles in both international military operations and internal security operations has been increasing in recent years, debates on the role of armed unmanned aerial vehicles in the international relations literature remain limited. While some experts consider armed unmanned aerial vehicle technology as a groundbreaking or game-changing development, others argue that the impact of this technological development is limited. This study presents an alternative assessment and new suggestions for increasing the effectiveness of armed unmanned aerial vehicles in conflict zones without positioning this study on any side of the ongoing debate in the literature. This study argues that armed drones should be supported by skilled military experts and modern military and electronic systems in order to make them more effective in conflicts. In order to test the accuracy of this hypothesis, this study examines Türkiye’s intervention in the Libyan Civil War, Türkiye’s Operation Spring Shield in Syria’s Idlib province, and Türkiye’s cooperation with Azerbaijan in the 44-day Patriotic War as case studies. Ultimately, the case studies uphold the hypothesis that the deployment of skilled military experts and modern military and electronic systems to support drones in combat increases their effectiveness.
ENGELLİ İŞ KOÇLUĞU PROGRAMININ ENGELLİ BİREYLERİN İSTİHDAMINA KATKISI: NİTEL BİR ARAŞTIRMA
Authors: Develi Abdülkadir , Mollaoğlu Huseyin
Published: January 2024

Engelli bireyler, toplumsal hayata tam katılım konusundaki engeller nedeniyle sosyal dışlanma riski altında olan önemli bir nüfusu temsil etmektedirler. Bu sosyal sorunun üstesinden gelmek amacıyla İŞKUR, aktif istihdam politikaları çerçevesinde iş koçluğu hizmetini başlatmıştır. Bu araştırma, engelli bireylerin iş bulma, iş gücü piyasasına aktif katılımlarını ve işte başarılı olma süreçlerini detaylı bir şekilde inceleyerek, Engelli iş koçluğu programlarının bu süreçlere olan katkısını değerlendirmeyi hedefleyen bir nitel araştırmadır. Araştırma, toplam 13 katılımcı ile gerçekleştirilmiştir; bu katılımcıların 4'ü kadın, 9'u erkektir. Veriler, mülakat yöntemi kullanılarak toplanmıştır. Toplanan veriler, MAXQDA nitel veri analiz yazılımı ile detaylı bir şekilde analiz edilmiştir. Çalışmanın bulguları, özellikle eğitim eksikliğinden kaynaklanan iletişim sorunları ve sosyal beceri eksikliklerinin iş arama süreçlerinde mülakatlar ve işyeri ilişkileri gibi sorunlara yol açabildiğini göstermektedir. Araştırmanın sonuçları, iş koçluğu programlarının engelli bireylerin iş bulma ve sürdürme süreçlerine olumlu katkılar sağladığını ve bu programların bu süreçlerde önemli bir rol oynadığını vurgulamaktadır.
Incremental dynamic analysis method application in the seismic vulnerability of infilled wall frame structures
Authors: Ma Weini
Published: January 2024

To reasonably evaluate the overall seismic performance of infilled wall frames, a corresponding nonlinear analysis model is constructed with infilled wall frames as the research object. It quantifies the failure levels of structural and non-structural components and proposes a method for extracting structural overall performance indicators. The vulnerability of the case frame structure is analyzed using the Incremental Dynamic Analysis (IDA) method. The results showed that the seismic performance of the infilled wall frame and the ordinary frame met the seismic fortification requirements, and the seismic capacity of the infilled wall frame was better. After implementing a 7-degree seismic fortification, the cumulative probability of basic integrity, minor damage, and moderate damage for infill wall frames reached 99.15 %, surpassing the fortification target of 1.5 g. However, the seismic capacity of ordinary frames was overestimated, as their cumulative probability of basic intact, minor damage, and moderate damage under a 7-degree seismic fortification was 99.7 %. Neglecting its impact, ordinary frames exhibited lower seismic performance compared to other structures, with a basic intact probability of only 48.49 % under frequent earthquake actions at 7 degrees. The research utilizes effective methods for evaluating the seismic vulnerability of infilled wall frames.
Nonlinear Dynamics of the Primary Oscillation Circuit of a Mems Gyroscope Under the Action of Phase-locked Loop and Automatic Gain Control Systems
Authors:   St Petersburg State University, Igumnova Vasilisa Sergeevna , Lukin Alexey Vyacheslavovich ,   St Petersburg State University, Popov Ivan Alekseevich ,   Advanced Engineering School "Digital Engineering", Kuznetsov Nikolay Vladimirovich ,   St Petersburg State University,   Institute for Problems in Mechanical Engineering of the Russian Academy of Sciences (IPMash RAS), Lobachev Mikhail Yurievich ,   St Petersburg State University, Belyaev Yakov Valerievich ,   Concern "CSRI Elektropribor"
Published: January 2024

In this work, we study the dynamics of primary oscillations of a high-Q micromechanical resonator - a sensitive element of an RR-type MEMS gyroscope - under the action of various implementations of a phase-locked loop system operating in conjunction with an automatic gain control system for an electrostatic drive. The study of the dynamics of the object is carried out both numerically and analytically - using the averaging method. Conditions for the stability of a stationary regime in a linear approximation are obtained. The questions of accuracy of various methods of numerical solution of differential equations of the circuit of primary oscillations are considered. The influence of the mechanical nonlinearity of the resonator on the dynamics of the resonator and the control system has been studied. An implementation of a low-order PLL circuit that does not contain a double-frequency spurious signal at the output of the phase detector is proposed. The output characteristics of control systems (speed, capture bandwidth, etc.) are analyzed and qualitative conclusions are drawn about the features of the interaction between the dynamics of a mechanical oscillatory link and the PLL-ARC circuit.
PHENOMENOLOGY AND ANTHROPOLOGY. FROM EDUARDO NICOL’S CONTRIBUTIONS
Authors:   Catholic University of Louvain, GÓMEZ ALGARRA CÉSAR ,   University of Valencia
Published: January 2024

This paper discusses why the work of Eduardo Nicol, still not translated and mostly unknown outside of the Hispanic context, deserves more attention, for two main reasons. First, the novelty of his meditations concerning phenomenology, following the steps of Husserl and Heidegger, but taking a different turn. Furthermore, several scholars have noted how his phenomenological project intertwines with the anthropological question, fostering a new approach to the question concerning “who are we?”. Our aim is to explore how Nicol, while setting foot in the founders of phenomenology, departs from previous interpretations of its method, to advance a new dialectical phenomenology that could contribute to the actual debates on anthropological phenomenology. In order to do so, we will first examine how his vision of the phenomenological task involves an historical interpretation of metaphysics and a critique of two fundamental concepts: the transcendental reduction (Husserl) and the thesis of an “occultation of being” (Heidegger). A careful reading of Nicol’s philosophy would allow us to go a step further and explain how, according to him, phenomenology should become an analysis of the dialectical presence between being/beings. Finally, we will show that the answer to the question “who are we?” is to be found inside this dialectic, in what Nicol identifies as the historical phenomenon of expression, encouraging a new dialogue with other phenomenologies of the body⸺and beyond.
JUAN DAVID GARCÍA BACCA’S READING OF TRANSCENDENTAL PHENOMENOLOGY. FROM INTENTIONAL CONSCIOUSNESS TO DEATH-FIGHTING CONSCIOUSNESS
Authors:   University of Wuppertal, FERRER ORTEGA JESÚS GUILLERMO
Published: January 2024

The Navarre-Venezuelan philosopher Juan David García Bacca is one of the most notable and original figures of Spanish-speaking thought, although his work has not yet received the attention it deserves. One of the pillars of his philosophy consists of what he calls a transfinite anthropology that considers man as an entity that strives to enhance his being. This anthropological approach is based on a phenomenology of nature that emphasizes the becoming and the transformations that man effects in the world. In this philosophical context, García Bacca soon became interested in the work of Husserl, Scheler y Heidegger. This article deals with the way in which García Bacca describes and values Husserl’s descriptions of intentional consciousness. The problem that García Bacca poses to transcendental phenomenology concerns neither the reality of pure consciousness nor its objective scope. García Bacca is interested in finding out if there is a potentiation of the being of consciousness superior to or deeper than the self-reflection proper to the transcendental attitude. He discovers this potentiation in the notion of an “agonic consciousness” that resists the representation of its annihilation, and whose philosophical antecedent is found in the work of Miguel de Unamuno. Without sharing all of García Bacca’s interpretation of Husserlian phenomenology, the author of the article considers that it nevertheless raises relevant questions concerning the facticity and necessity proper to the transcendental subject.
ТHE REVIEW OF ТHE INТERNAТIONAL SCIENТIFIC WORKSHOP “ТHE ТRANSCENDENТAL ТURN IN MODERN PHILOSOPHY — 8: ТRANSCENDENТAL MEТAPHYSICS, EPISТEMOLOGY, TRANSCENDENTAL COGNITIVE SCIENCE AND ARIFICIAL INTELLIGENCE” (April 20–22, 2023, Moscow, Russia)
Authors:   Russian State University for Humanities, SHIYAN ANNA
Published: January 2024

This article presents a review of papers of the international scientific seminar “Transcendental Turn in Modern Philosophy — 8: Metaphysics, epistemology, transcendental cognitive science and artificial intelligence,” which was held on April 20–22, 2023 in Moscow. The topics reviewed were the following: “Transcendental Philosophy: Ontology, Metaphysics of Experience or Epistemology,” “Transcendentalism, Cognitive Science and Artificial Intelligence,” “Reception and Development of Transcendental (Phenomenological) Approach in Modern Philosophy,” as well as “Transcendental Phenomenology: Ontology and/or Gnoseology”. The author analyzes the presentations of the participants, grouping them around the following thematic and problematic nodes: the transcendental foundations of cognitive sciences, the understanding and status of the transcendental unity of apperception, the relationship between gnoseology and ontology in phenomenological research, receptivity and construction in forming the subject of knowledge, etc. This approach makes it possible to identify different, sometimes opposing positions of the participants on the same question and to outline ways to overcome the contradictions.
A deep learning-based hybrid approach for multi-time-ahead streamflow prediction in an arid region of Northwest China
Authors: Fang Jinjie , Yang Linshan , Wen Xiaohu , Li Weide , Yu Haijiao , Zhou Ting
Published: January 2024

Accurate streamflow prediction is crucial for effective water resource management. However, reliable prediction remains a considerable challenge because of the highly complex, non-stationary, and non-linear processes that contribute to streamflow at various spatial and temporal scales. In this study, we utilized a convolutional neural network (CNN)–Transformer–long short-term memory (LSTM) (CTL) model for streamflow prediction, which replaced the embedding layer with a CNN layer to extract partial hidden features, and added an LSTM layer to extract correlations on a temporal scale. The CTL model incorporated Transformer's ability to extract global information, CNN's ability to extract hidden features, and LSTM's ability to capture temporal correlations. To validate its effectiveness, we applied it for streamflow prediction in the Shule River basin in northwest China across 1-, 3-, and 6-month horizons and compared its performance with Transformer, CNN, LSTM, CNN–Transformer, and Transformer–LSTM. The results demonstrated that CTL outperformed all other models in terms of predictive accuracy with Nash–Sutcliffe coefficient (NSE) values of 0.964, 0.912, and 0.856 for 1-, 3-, 6-month ahead prediction. The best results among the five comparative models were 0.908, 0.824, and 0.778, respectively. This indicated that CTL is an outstanding alternative technique for streamflow prediction where surface data are limited.
Impact of abattoirs and local textile (Adire and Kampala) effluents on Yemoja River in Abeokuta, Nigeria
Authors: Ogundairo Emmanuel Sanu , Folarin Gbolahan Muyiwa , Awomeso Julius Awonusi , Taiwo Adewale Matthew
Published: January 2024

Discharge of untreated wastewater into water bodies pollutes the receiving waters. This study assessed the impact of abattoir and Kampala designers' effluent discharge on the water quality of the Yemoja River in Abeokuta, Nigeria. Twenty-seven water samples collected at three points, covering 180 m length, for 6 months were assessed for physicochemical parameters and metals and compared with the World Health Organization (WHO) and Standard Organization of Nigeria (SON) permissible standards. Most discharge point levels were found to be higher than their corresponding upstream and downstream values. Temperature, turbidity, magnesium, alkalinity, DO, TSS, phosphate, lead, BOD and potassium were found to be higher than normal levels for river water as prescribed by the WHO and SON while parameters like TDS, TS, calcium, chloride, nitrate, sulphate, iron and COD were lower than the standards. The total coliform values were higher than both national and international permissible limits, indicating contamination by human sewage or animal droppings. The water quality index indicated polluted water that is unfit for consumption. Findings from this research indicate that butchering and tie-and-dye activities have impacted river Yemoja water quality. Therefore, wastewater from the abattoir and textile industries be treated before discharge into water bodies.
Studi Evaluasi Saluran Drainase di Desa Kuang, Kecamatan Taliwang, Sumbawa Barat
Authors: Ivan Bintang Arfiansyah  , Ussy Andawayanti  , Linda Prasetyorini
Published: January 2024

Desa Kuang Kecamatan Taliwang yang terletak di Kota Sumbawa Barat Provinsi Nusa Tenggara Barat merupakan salah satu daerah yang sering terjadi banjir. Pertambahan penduduk dan perkembangan wilayah, ditambah dengan topografi yang cenderung datar menyebabkan penyimpanan saluran drainase yang ada sudah tidak cukup untuk menangani jumlah curah hujan yang tidak dapat diserap oleh tanah. Pada penelitian ini perlu dilakukan analisis intensitas curah hujan rencana dengan rentan waktu 5 tahun (R5). Selanjutnya menganalisis penyimpanan saluran drainase eksisting dengan memodelkan aplikasi EPA SWMM 5.2. Setelah mendapatkan informasi dari model, perlu dilakukan evaluasi terhadap saluran drainase eksisting. Saluran yang tidak mencukupi atau meluap akan diubah ukurannya seperti yang terjadi pada saluran C7, C16, C25, C20, C34, C27, C21, C22, C23, C31, C32 dan C37. Saluran C38 memiliki kekurangan kapasitas terbesar dengan total debit mencapai 0,184 m3/s. Untuk aliran tak terdukung total di lokasi studi adalah 0,37 m3/dt. Oleh karena itu perlu dilakukan evaluasi besaran saluran pada titik banjir dengan U-Ditch. Perkiraan dana yang dibutuhkan dalam pembangunan drainase sejumlah Rp. 851.741.000
Studi Potensi Airtanah Untuk Perencanaan Jaringan Irigasi Air Tanah Di Kecamatan Badegan, Kabupaten Ponorogo
Authors: Widyaningrum Aprilia , Sri Wahyuni  , Anggara Wiyono Wit Saputra
Published: January 2024

Desa Tanjunggunung dan Desa Karangjoho, Kecamatan Badegan, Kabupaten Ponorogo merupakan sebuah daerah yang seringkali mengalami kekeringan. Sedangkan masyarakat di wilayah tersebut mayoritas bermata pencaharian sebagai petani. Maka dari itu, diperlukan suatu upaya untuk mengoptimalkan pemanfaatan airtanah sebagai sumber air irigasi dengan metode pendugaan geolistrik dan perencanaan jaringan irigasi air tanah dengan program WaterCAD V8i. Hasil pendugaan geolistrik dan interpretasi data pada titik lintasan geolistrik setelah diolah menggunakan program IPI2WIN dan Progress 3.0 menunjukkan terdapat tiga lapisan litologi yaitu berupa batu pasir, lempung, dan kerakal. Berdasarkan penentuan nilai transmisivitas yang paling besar dan jarak radius antara titik yang telah ditentukan dengan luasan sawah, dihasilkan potensi air tanah sebesar Q = 35 liter/detik. Perencanaan jaringan irigasi air tanah menggunakan sistem pipa hubungan seri dengan pola operasi sistem rotasi. Jenis sumur yang direncanakan menggunakan sumur dalam (Deep Tube Well) dan pompa yang digunakan yaitu pompa tenggelam (submersible) merk Grundfos tipe 95-6. Kemudian, nilai yang didapatkan dalam perhitungan kebutuhan air di sawah (NFR) yaitu sebesar 1,03 liter/detik/hektar. Rencana Anggaran Biaya (RAB) total yang diperlukan untuk pembangunan jaringan irigasi air tanah di Desa Tanjunggunung dan Desa Karangjoho, Kecamatan Badegan sebesar Rp. 3.495.663.676.00.
Pemanfaatan Data Hujan Satelit dalam Pembuatan Peta Spasial Hujan Rancangan di DAS Welang Kabupaten Pasuruan
Authors: Azizah Salma , Harisuseno Donny , Wahyuni Sri
Published: January 2024

Abstrak: Salah satu prioritas penanganan di DAS Welang yaitu permasalahan banjir yang masih terjadi terutama pada bagian hilir setiap tahunnya, hal ini tidak terlepas dengan siklus hidrologi yang mengalami perubahan. Untuk mengatasi permasalahan minimnya ketersediaan data hujan, maka alternatif yang dapat digunakan adalah menggunakan curah hujan satelit. Dengan menggunakan teknologi penginderaan jauh, curah hujan satelit memungkinkan mendapatkan akses cepat, gratis, cakupan yang luas, dan dalam data near real time. Studi ini menggunakan data satelit jenis CHIRPS dengan resolusi 0,05 x 0,05 arc degrees sebagai data pendukung untuk membuat peta spasial. Data hujan pengamatan disesuaikan dengan data satelit yang telah dikalibrasi. Peta interpolasi spasial dibuat menggunakan distribusi Gumbel dan Log Pearson III dengan kala ulang 2, 5, 10, 25, 50, dan 100 tahun. Hasil peta hujan rancangan divalidasi dengan membandingkannya dengan hasil analisis distribusi dan peta stasiun hujan pengamatan. Validasi dengan NSE dan RSR menunjukkan hasil yang sangat baik dan perbandingan dengan peta stasiun hujan pengamatan menunjukkan hasil yang sangat baik terhadap analisis distribusi. Selanjutnya, peta tersebut dibandingkan dengan peta hujan rancangan yang diterbitkan oleh Kementerian Pekerjaan Umum Perumahan Rakyat  hasilnya menunjukkan kesesuaian sebesar 10%.
Conjugacy classes and conjugate graph of a K-metacyclic group
Authors:   Department of Mathematics, Gauhati University, Guwahati, Assam, India, Yangertola Yangertola , Patra Kuntala ,   Department of Mathematics, Gauhati University, Guwahati, Assam, India
Published: January 2024

The relationship between algebraic structures and graphs has become an interesting topic of research nowadays. In this paper, we have considered the conjugate graph related to the conjugacy relation of a group. The vertices of the said graph are the noncentral elements of the group, and two vertices are adjacent if they are conjugate. For this particular study, we focused on the conjugate graph of a K-metacyclic group of order p(p-1). We first determine the conjugacy classes of this group and then obtain its conjugate graph. Various graph properties such as planarity, line graph, complement graph, clique number, dominating number, spectrum, and Laplacian are also studied in this paper.
The development of skills and awareness in integrating content, teaching methods, and technology in the learning management for teachers in the education sandbox, Thailand
Authors: Damrongpanit Suntonrapot , Chamrat Suthida , Manokarn Monnapat
Published: January 2024

This research aims to develop science teachers teaching in innovative educational institutions in Thailand, with a total of 68 participants, to have integrated skills in content and technology management and to increase their awareness of technology integration in the classroom. The development approach used the concept of Technological Pedagogical Content Knowledge (TPACK) combined with online blended learning, focusing on knowledge development, practical training, and application over a period of approximately three months. The data were analyzed using descriptive statistics, cross-tabulation analysis, and content analysis. The main findings of the research are as follows: 1) The trained teachers showed improvement in various aspects ranging from 17.201% to 22.727%, with the highest development observed in TPK, followed by PCK and PK. The area with the least improvement was TK. In addition, it was found that the integration of technology in instructional design by teachers tended to increase by two levels. The most commonly used technology was for learning management, followed by communication, knowledge testing, instructional media creation, and the use of educational games, and 2) the majority of teachers demonstrated an increasing awareness of integrating content management with technology in their teaching practices. They actively sought out new technological networks to support their instructional design activities. They planned their work to improve instruction through more effective use of technology. They sought additional ways to increase their knowledge and expertise in using technology in the classroom, and they expressed significant concerns about their current use of technology and its declining impact.
The Impact of Wireless Emergency Alerts on a Floating Population in Seoul, South Korea: Panel Data Analysis
Authors: Yoon Sungwook , Lim Hyungsoo , Park Sungho
Published: January 2024

Background

Wireless emergency alerts (WEAs), which deliver disaster information directly to individuals’ mobile phones, have been widely used to provide information related to COVID-19 and to encourage compliance with social distancing guidelines during the COVID-19 pandemic. The floating population refers to the number of people temporarily staying in a specific area, and this demographic data can be a useful indicator to understand the level of social distancing people are complying with during the COVID-19 pandemic.

Objective

This study aimed to empirically analyze the impact of WEAs on the floating population where WEAs were transmitted in the early stages of the COVID-19 pandemic. As most WEA messages focus on compliance with the government’s social distancing guidelines, one of the goals of transmitting WEAs during the COVID-19 pandemic is to control the floating population at an appropriate level.

Methods

We investigated the empirical impact of WEAs on the floating population across 25 districts in Seoul by estimating a panel regression model at the district-hour level with a series of fixed effects. The main independent variables were the number of instant WEAs, the daily cumulative number of WEAs, the total cumulative number of WEAs, and information extracted from WEAs by natural language processing at the district-hour level. The data set provided a highly informative empirical setting as WEAs were sent by different local governments with various identifiable district-hour–level data.

Results

The estimates of the impact of WEAs on the floating population were significantly negative (–0.013, P=.02 to –0.014, P=.01) across all specifications, implying that an additional WEA issuance reduced the floating population by 1.3% (=100(1–e–0.013)) to 1.4% (=100(1–e–0.014)). Although the coefficients of DCN (the daily cumulative number of WEAs) were also negative (–0.0034, P=.34 to –0.0052, P=.15) across all models, they were not significant. The impact of WEAs on the floating population doubled (–0.025, P=.02 to –0.033, P=.005) when the first 82 days of observations were used as subsamples to reduce the possibility of people blocking WEAs.

Conclusions

Our results suggest that issuing WEAs and distributing information related to COVID-19 to a specific district was associated with a decrease in the floating population of that district. Furthermore, among the various types of information in the WEAs, location information was the only significant type of information that was related to a decrease in the floating population. This study makes important contributions. First, this study measured the impact of WEAs in a highly informative empirical setting. Second, this study adds to the existing literature on the mechanisms by which WEAs can affect public response. Lastly, this study has important implications for making optimal WEAs and suggests that location information should be included.
Investigating the Roles and Responsibilities of Institutional Signing Officials After Data Sharing Policy Reform for Federally Funded Research in the United States: National Survey
Authors: Baek Jinyoung , Lawson Jonathan , Rahimzadeh Vasiliki
Published: January 2024

Background

New federal policies along with rapid growth in data generation, storage, and analysis tools are together driving scientific data sharing in the United States. At the same, triangulating human research data from diverse sources can also create situations where data are used for future research in ways that individuals and communities may consider objectionable. Institutional gatekeepers, namely, signing officials (SOs), are therefore at the helm of compliant management and sharing of human data for research. Of those with data governance responsibilities, SOs most often serve as signatories for investigators who deposit, access, and share research data between institutions. Although SOs play important leadership roles in compliant data sharing, we know surprisingly little about their scope of work, roles, and oversight responsibilities.

Objective

The purpose of this study was to describe existing institutional policies and practices of US SOs who manage human genomic data access, as well as how these may change in the wake of new Data Management and Sharing requirements for National Institutes of Health–funded research in the United States.

Methods

We administered an anonymous survey to institutional SOs recruited from biomedical research institutions across the United States. Survey items probed where data generated from extramurally funded research are deposited, how researchers outside the institution access these data, and what happens to these data after extramural funding ends.

Results

In total, 56 institutional SOs participated in the survey. We found that SOs frequently approve duplicate data deposits and impose stricter access controls when data use limitations are unclear or unspecified. In addition, 21% (n=12) of SOs knew where data from federally funded projects are deposited after project funding sunsets. As a consequence, most investigators deposit their scientific data into “a National Institutes of Health–funded repository” to meet the Data Management and Sharing requirements but also within the “institution’s own repository” or a third-party repository.

Conclusions

Our findings inform 5 policy recommendations and best practices for US SOs to improve coordination and develop comprehensive and consistent data governance policies that balance the need for scientific progress with effective human data protections.
Implementing a Sodium-Glucose Cotransporter 2 Inhibitor Module With a Software Tool (Future Health Today): Qualitative Study
Authors: Suen Matthew , Manski-Nankervis Jo-Anne , McBride Caroline , Lumsden Natalie , Hunter Barbara
Published: January 2024

Background

Primary care plays a key role in the management of type 2 diabetes. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been demonstrated to reduce hospitalization and cardiac and renal complications. Tools that optimize management, including appropriate prescribing, are a priority for treating chronic diseases. Future Health Today (FHT) is software that facilitates clinical decision support and quality improvement. FHT applies algorithms to data stored in electronic medical records in general practice to identify patients who are at risk of a chronic disease or who have a chronic disease that may benefit from intensification of management. The platform continues to evolve because of rigorous evaluation, continuous improvement, and expansion of the conditions hosted on the platform. FHT currently displays recommendations for the identification and management of chronic kidney disease, cardiovascular disease, type 2 diabetes, and cancer risk. A new module will be introduced to FHT focusing on SGLT2 inhibitors in patients with type 2 diabetes who have chronic kidney diseases, cardiovascular diseases, or risk factors for cardiovascular disease.

Objective

The study aims to explore the barriers and enablers to the implementation of an SGLT2 inhibitor module within the Future Health Today software.

Methods

Clinic staff were recruited to participate in interviews on their experience in their use of a tool to improve prescribing behavior for SGLT2 inhibitors. Thematic analysis was guided by Clinical Performance Feedback Intervention Theory.

Results

In total, 16 interviews were completed. Identified enablers of use included workflow alignment, clinical appropriateness, and active delivery of the module. Key barriers to use were competing priorities, staff engagement, and knowledge of the clinical topic.

Conclusions

There is a recognized benefit to the use of a clinical decision support tool to support type 2 diabetes management, but barriers were identified that impeded the usability and actionability of the module. Successful and effective implementation of this tool could support the optimization of patient management of type 2 diabetes in primary care.
Development of a Core Outcome Set for Family and Community Nursing: Protocol for a Delphi Study
Authors: Russo Sara , Caruso Rosario , Conte Gianluca , Magon Arianna , Vangone Ida , Bascape' Barbara , Maga Giulia , Pasek Malgorzata , Arrigoni Cristina
Published: January 2024

Background

Family and community nurses (FCNs) play a crucial role in delivering primary care to patients within their homes and communities. A key aspect of their role involves various health interventions, which are influenced by their unique competencies, such as health promotion, advanced clinical knowledge, and strong interpersonal skills. However, it is essential to understand which specific health outcomes these interventions impact to better understand the relationship between FCNs’ skills and the health results.

Objective

This study aims to outline the steps we will take to develop a set of core outcomes. These outcomes will be particularly sensitive to the health interventions carried out by FCNs, providing a clearer picture of their practice’s impact.

Methods

A Delphi survey will be used for this research, conducted from January to December 2024. The process will involve 5 steps and input from 3 stakeholder categories. These stakeholders will help identify a preliminary list of outcomes that will form the basis of our core outcome set (COS).

Results

This guideline will be beneficial for a wide range of stakeholders involved in COS development, including COS developers, trialists, systematic reviewers, journal editors, policy makers, and patient groups. As of January 2024, we have successfully completed the first stage of the study, with the stakeholder group approving the reported outcomes and assigning participant lists for each stakeholder group.

Conclusions

This study will provide a roadmap for identifying the key health outcomes influenced by the interventions of FCNs. The multistakeholder, multiphase approach will ensure a comprehensive and inclusive process. Ultimately, the findings will enhance our understanding of FCNs’ impact on health outcomes, leading to more effective primary care strategies and policies.

International Registered Report Identifier (IRRID)

PRR1-10.2196/51084