bluuebunny/crossref_metadata_2025 huggingface dataset:
Características clínicas y laboratoriales de la infección por el virus Chikungunya en pacientes en edad pediátrica del Instituto de Medicina Tropical
Authors: Lovera Dolores , Gianninoto Eliana , Ayala Pereira Jorge Luis Enrique , Galeano Fernando , Amarilla Sara , Aguiar Carlos , González Nicolás , Figueredo Juan , Merlo Oscar , Martínez de Cuellar Celia
Published: April 2023

Introducción: La fiebre chikungunya (FCHIK) es una enfermedad febril transmitida por mosquitos, que en el niño tiene manifestaciones clínicas diferentes, dependiendo del grupo de edad.
Objetivo: el presente trabajo tiene el propósito de identificar las características clínicas y evolutivas de la FCHIK en pacientes ≤15 años, que acudieron al Instituto de Medicina Tropical (IMT).
Materiales y método: estudio observacional, descriptivo retrospectivo, basado en revisión de historias clínicas de pacientes de 0 y 15 años, que consultaron al IMT, entre noviembre/2022 y marzo/ 2023, con diagnóstico de FCHIK. Resultados: de 2050 pacientes febriles que consultaron al IMT entre noviembre/2022 y marzo/2023, 301 fueron casos confirmados de FCHUK, 10,6% (32/301) requirió hospitalización, de estos el 62,5% (20/32) era ≤1 año. La presencia de vómitos (p<0.0001.OR= 5,5 IC95% 2.2–13.2), dolor abdominal (p<0.0001.OR=40.5,5 IC95% 4.5–364.3); erupción maculo-papular-ampollar p<0.008. OR=3.5, IC95% 1.3 – 9.1), fue significativamente más frecuente en los hospitalizados.  El 37.5% (12/32) fue hospitalizado en UCI y 15,6% (5/32) requirió ARM, 18.7%(6/32) presentó miocarditis; 15.6%(5/32) encefalitis, y 3.1%(1/32) encefalitis y miocarditis.    No se registraron óbitos.
Conclusiones: La décima parte de los pacientes con FCHIK requirieron hospitalización, de estos más de la mitad fueron <1 año. Las manifestaciones clínicas más frecuentes fueron fiebre, exantema, vómitos, irritabilidad, artralgias, lesiones ampollares. La leucopenia fue significativamente más frecuente en ≤1 año. La edad <3 meses, así como vómitos, exantema vesículo-ampollar, presencia de choque, irritabilidad, convulsiones, dolor abdominal y dificultad respiratoria se asociaron significativamente al requerimiento de hospitalización. Las complicaciones más frecuentes fueron el choque, la miocarditis y la encefalitis.
Frecuencia y características de la encefalopatia hipertensiva secundaria a glomerulonefritis posinfecciosa en pacientes internados en un hospital de referencia nacional
Authors: Troche Avelina , Samudio Margarita , Avalos Domingo , Adorno Teresita , Basabe Mearlyn , Nuñez Nilsa , Duarte Cynthia , Gómez Nidia , Lezcano Fabiola , Araya Soraya
Published: April 2023

Introducción: La glomerulonefritis aguda pos infecciosa (GNPI) puede cursar con complicaciones como la encefalopatía hipertensiva en 7-11% de los casos.
Objetivo: determinar la frecuencia y características de la encefalopatía hipertensiva (EH) secundaria a GNPI en pacientes internados en el Departamento de Pediatría del Hospital Nacional en el periodo enero/2000-diciembre/2018.
Materiales y Métodos: Estudio observacional, descriptivo, retrospectivo de pacientes con síndrome nefrítico (SN) con C3 disminuido y normalización a los tres meses, con hipertensión arterial (HTA) severa acompañada de manifestaciones neurológicas (cefalea, náuseas, vómitos, alteración de conciencia, convulsiones), que cedieron al regularizarse la HTA. Se estudiaron las características sociodemográficas (edad, sexo, procedencia, escolaridad de los padres, número de hijos) y clínicas (edema periférico, edema agudo de pulmón, hematuria, y manifestaciones neurológicas). Los datos fueron analizados utilizando estadística descriptiva mediante EPIINFO (CDC, Atlanta), expresando las variables cuantitativas como mediana y rango intercuartílico (RIC) y las cualitativas como frecuencia absoluta y porcentual.
Resultados: 27 /160 (16,8%) pacientes, desarrollaron EH. La edad varió entre 3 a 16 años (mediana: 10 años; RIC: 5); el antecedente infeccioso más frecuente fue piodermitis (40,7%), seguido de faringitis aguda (37%). Todos los pacientes presentaron edema periférico y cefalea intensa. La duración de la HTA tuvo una mediana de 5 días (RIC: 4) y los días de internación una mediana de 7 (RIC: 6). Ningún paciente requirió diálisis ni quedó con secuelas, no se registraron óbitos. Conclusión: en pacientes con EH debe considerarse el diagnóstico de GNPI, investigando antecedentes infecciosos y valorando adecuadamente la volemia.
The main provisions of the methodology for ensuring the resistance of the onboard equipment of spacecraft to the effects of the radiation effects of outer space
Authors: Maximov Igor A. , Kochura Sergey G. , Avdyushkin Sergey A.
Published: April 2023

In this paper, the problematic issues of ensuring the resistance of the onboard equipment of spacecraft to the effects of ionizing radiation from outer space, which significantly limits the period of active existence of the spacecraft, are considered. The paper describes the methodology) for ensuring radiation resistance, developed by the specialists of JSC ISS. The result of the work done is to ensure the guaranteed performance of the target function by spacecraft with long period of active lifetime of 15 or more years.
Among the complex of outer space factors affecting the spacecraft, ionizing radiation of outer space is the main factor limiting the period of active existence. Exposure to energetic particles of ionizing radiation from outer space causes degradation of the electronic component base, which leads to failures and malfunctions of on-board equipment and degradation of its functional surfaces. Ensuring the radiation resistance of a spacecraft (SC) is a complex task, one of the stages of which is to determine the radiation resistance of components that complete the on-board equipment. As a result of accumulated experience in conducting radiation tests and analysis of the results, specialists of JSC ISS developed a methodology that allows to guarantee the radiation resistance of the spacecraft under conditions of tight production deadlines and optimized costs.
Possibility of unification of requirements for radiation resistance for spacecraft with different operating conditions
Authors: Nazarenko Anton A. , Maximov Igor A. , Kochura Sergey G.
Published: April 2023

During the period of active lifetime in different types of orbits, spacecraft are exposed to various factors of outer space. Die main factor influencing the performance of electronic equipment is the ionizing radiation of outer space.
The main effect associated with the impact of the ionizing radiation of outer space on the spacecraft (dose effects), in its physics, is determined by the radiation dose absorbed in the components of the electronic component base and construction materials during the entire lifetime. This effect explains the failures in the operation of radio-electronic equipment due to the degradation of the parameters used in the products of the electronic component base and materials.
Calculation of levels of exposure to absorbed doses depending on various parameters of the orbit is a necessary and important task for ensuring the functioning of the spacecraft during a given lifetime, since calculations of radiation resistance are based on the levels of exposure in orbit.
The key, from the point of view of minimizing mass protection and the scope of testing of critical electronic component base products, is to carry out calculations taking into account the design features of the spacecraft and on-board equipment. In addition to taking into account the design of the spacecraft and the spacecraft, an important aspect when calculating the radiation resistance is taking into account the relative position of the spacecraft in the spacecraft.
This article considers the possibility of unifying the requirements for radiation resistance for spacecraft with different operating orbits and lifetime, as well as the possibility of carrying out a unified calculation without taking into account the design features of the spacecraft, spacecraft and relative position within the spacecraft.
The aircraft hydraulic system units and pipelines heat exchange parameters study
Authors: Nikolaev Vladimir N.
Published: April 2023

A method of mathematical simulation of the aircraft hydraulic system thermal state is proposed. The mathematical model is a system of partial differential equations for carbon-fiber composite thermal insulation and ordinary differential equations for hydraulic system elements that describe their heat exchange with the air and surrounding surfaces. To solve the direct problem of the hydraulic system elements thermal state, that is, to solve stiff ordinary differential equations, a Rosenbrock-type second order approximation numerical scheme for non-autonomous systems and the solution of a system of partial differential equations, the Monte Carlo method based on a probabilistic representation of the solution in the form of a diffusion process functional expectation were used. The inverse problem of the hydraulic system elements thermal state is solved by the composition of the steepest descent method, the Newton method and the quasi-Newton method of Broyden-Fletcher-Goldfarb-Shanno. A thermal state mathematical model of the hydraulic system unit in an aircraft unpressurized compartment has been developed and the confidence intervals of each of the required model coefficients have been estimated using 12 at a confidence probability = 0.95.
Taiwan, China and the Meta-civilizational World System of Eastern Asia: Towards a New Vision of Asian Globality
Authors: Malyavin Vladimir
Published: April 2023

The stalemate in China-Taiwan relations calls for new approaches to the problem of security and stability in APR. The article examines the current confrontation between the "two sides of the Taiwan Strait" in its relation to Chinese civilization’s specificity and globalization processes. Taiwan is not just China's periphery, but also the last Chinese frontier. Taiwan's politics of "de-sinicization" and transformation of the Taiwanese into an "Oceanic Nation" is considered in the three-dimensional context of modern Chinese civilization: the continental centralized state of imperial type, represented by the "Middle Kingdom" concept, the Chinese periphery and the Chinese diaspora, representing the global aspect of Pax Sinica. A real focus of this structure is precisely the point of Frontier, a sort of heterotopy with its capacity to bring together singularity and universality, internal and external aspects of existence. The author offers a new concept of Greater China as a link between the local and the global aspects of Chinese civilization. This mediation is realized through the transformation of various qualities of existence into its persisting types as the symbols of the fullness of existence. These types create a special kind of communicative space which constitutes the East Asian meta-civilizational world system. This approach to the relationship between China and Taiwan and their globalist aspirations reveals a special East Asian type of globality, in which cooperation between China and Taiwan can be reconciled on the synergy basis, despite their widely divergent political systems. The Pacific region is a convenient testing ground for this type of relationship.
A Taxation in Old Turkic States. Part 2: Settled Agricultural Subjects of the he Western Türks
Authors: Tishin Vladimir V.
Published: April 2023

Limited source base determines different views of researchers on fiscal practices in political formations created and headed by the tribes of the Early Turkic group. The present paper continues an attempt to summarize different evidences of any taxation in the Türkic Qaghanates and their regional successors in Eurasian steppes and adjacent territories with a settled agricultural population. A special attention should be paid to the possessions of the Western Türkic dynasties with settled agricultural population on the territory of Central Asia and Afghanistan. It is possible to identify the certain patterns given the accumulated experience of comparative studies of nomadic societies. First, there is no evidence that the nomadic population, which belonged to the dominant tribal group, was exploited in any way. Secondly, from the subordinate nomadic and forest hunting tribes all the collections were subjected to taxation of natural products without any regularity and depending solely on the discretion of the representatives of the dominant tribe were directly at their head. Thirdly, the fiscal levies for the conquered sedentary agricultural people were carried out according to the practices prevailing earlier in a particular locality. The agents of the central (qaghanal) government were appointed over such subordinate peoples to exist on a par with the local dynastic rulers. They did not directly influence their domestic policies and, apparently, had only to control the timeliness of payments, among other obligations that their citizenship status implied.
“Retention” of Sorcery and Exorcism in Today’s Soqotran Culture
Authors: Naumkin Vitaliy
Published: April 2023

The present study, based on the field materials gathered during a fieldwork season with Soqotri informants in Summer, 2022, honors the memory of our friend and colleague Victor Porkhomovsky, an outstanding Africanist and Semitologist tragically passed away a few months ago. In the mid-1970s, Professor Porkhomovsky played an important role in Naumkin’s endeavors to assess, linguistically and culturally, the Soqotri data collected during his early research trips to the island. In the present article, the authors, two of whom have been jointly collecting, systematizing and analyzing the Soqotri oral legacy during the last 15 years, attempt to demonstrate that the belief in sorcery and supernatural creatures remains part and parcel of the traditional culture of the islanders. If such rites and ceremonies as water and fire ordeals are not practiced anymore, they were replaced by other forms of de facto exorcism. The belief in sorcery, although substantially weakened, is still largely retained in the culture of today’s Soqotrans, all forms of modernization notwithstanding. Moreover, this belief played not a small role in the preservation of their oral heritage, intimately connected to ancient rites and practices (notably, initiation). Some structural and narrative elements of the canonical myths, legends and folk tales are examined (such as binary oppositions or snake fighting), side by side with such concepts as demonic obsession and fear of death. A few Soqotri texts dealing with sorcery are published for the first time. A few relevant terms (such as ḳábe ‘magic power’) are analyzed at some length.
Protestant Missionary Accounts of Chinese Secret Societies in the Beginning of the 19th Century
Authors: Stezhenskaya Lidiya
Published: April 2023

The paper examines the earliest information by Europeans concerning activities of the secret societies–traditional public organizations that have played a significant role in history of China and continues to be a phenomenon of public life in China and abroad. By analogy with the “colonial school” of the studies of secret societies in China, it is proposed to single out the earliest period of the Protestant historiography of secret societies, tentatively designating it as a “missionary school” of William Milne and Robert Morrison. Amendments are done to the available bio-bibliographic data on Milne’s publications in The Indo-Chinese Gleaner. The authorship and time of the reports on secret societies in China delivered by R. Morrison at the Royal Asiatic Society are clarified. Milne’s reports indicated that the secret societies were anti-government, and some of them were anti-Qing. However, he did not notice the slogans for the restoration of the late Chinese Ming dynasty. The purpose of the destruction of the Qing dynasty is directly expressed in the materials of R. Morrison, which also talked about the hope for help from the spirits of the Ming emperors. It is noted that the ‘Mason paradigm’ of the study of secret societies proposed by W. Milne was based on the similarity of some formal aspects in their activities with the practice of the Freemason Society in Great Britain. At the same time, W. Milne pointed out the differences in the social status and social role of such societies in Europe and in China.
The Shi'a movements and proxy groups in context of the Middle Eastern policy of the Islamic Republic of Iran
Authors: Kuznetsov Alexander
Published: April 2023

This article is dedicated to the role and significance of the Iranian proxy-groups in the system of international relations in the Middle East and national security structures of the Islamic Republic of Iran. The relevance of this work stems from significant increase of the Iranian influence in the region over the past ten years. The article includes research of the activity of Iranian proxies in specific countries (Lebanon, Syria, Iraq); analysis of their genesis and increasing political activity; research of their influence on the augment of conflict potential between Iran and Israel; analysis of these groups’ functions in the system of national security of Iran. The author of the article points out, among other factors, that the Hezbollah movement in Lebanon has considerably strengthened its positions in the recent years due to a number of reasons, first of all, the movement’s victory in the military conflict with Israel in 2006. The second reason is various political alliances and coalitions with other Lebanese parliamentary parties; the third one is considerable military experience obtained by Hezbollah in the civil war in Syria (2013–2019). The author also emphasizes Hezbollah’s significant influence in the military and political spheres of Iraq, which are held by the pro-Iranian “Al Khashd al Shaabi” created by Shi‘a parties. In conclusion, the author provides a review of  these groups’s relations with Iran and their prospects. The Iranian proxy groups play a significant role in the national security of Iran. Taking Iran’s confrontation with the US, Israel and Saudi Arabia into account, these groups are providing deterrence against probable aggression of the US and Israel towards Iran.
Excavation of the Western Suburban Complex of Bol’shoy K’irk-K’iz in 2022
Authors: Balakhvantsev Archil S.
Published: April 2023

During the 2022 excavation season at the Western Suburban Complex (WSC), work on Room III (Blue Hall) has been continued. Two fragments of pottery discovered there date back to the ancient Chorasmian period. At the -210 and -212 cm levels from the benchmark, a flooring consisting of mud brick pavement was discovered (41–42 × 41–42 cm).
The most numerous finds in the 2022 season were fragments of painting, made with glue paint on loess plaster, covered with white loose soil – gypsum in the form of dihydrate. The polarizing microscopy of the composition of paint samples showed that the blue pigment consists of natural ultramarine, the red-brown one is red ocher, and the green paint is made of atacamite (copper hydroxychloride).
When Room III had ceased functioning normally, it lost its roof and has been gradually filled with various layers of ground. Judging by the complete absence of animal bones, hearths and/or bonfires, as well as the meager amount of ceramics, secondary habitation of the ruined premises is clearly improbable. The discovered brick pavements are not related to the period of the WSC’s functioning and appeared after the process of destruction of the walls had gone far enough.
The last stage of the destruction corresponds to the layer lying on top of the brickwork in the northeast corner of Room III, containing numerous fragments of painted plaster. The lifetime and destruction of the WSC fully corresponds to the ancient Chorasmian period.
КОМПОНЕНТИ, КРИТЕРІЇ ТА ПОКАЗНИКИ РІВНІВ ГОТОВНОСТІ МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВОЇ ШКОЛИ ДО ЗАСТОСУВАННЯ ІННОВАЦІЙНИХ ТЕХНОЛОГІЙ
Authors: ОСТРОВСЬКА Маріанна
Published: April 2023

Підготовка нової генерації вчителів початкових класів, здатних відходити від традиційних форм і методів роботи з учнями і водночас сприймати й екстраполювати новий педагогічний досвід, нові технології, форми і методи роботи у свою професійну діяльність, спрямована на усвідомлення необхідності створення позитивного навчального середовища шляхом активізації інтелектуальних і почуттєвоемоційних ресурсів кожного учня. Саме тому виникає необхідність застосування у професійній освіті відповідних педагогічних технологій. Це, в свою чергу, актуалізує необхідність включення у предметно-методичну підготовку майбутніх учителів початкових класів відповідного змісту, вимагає переосмислення й пошуку нових організаційних форм і методів навчання, які покращили б його якість та ефективність, розширили та поглибили зміст професійної підготовки. Зазначене обумовлене новітніми тенденціями розвитку соціальних, міждержавних, культурних зв’язків у галузі професійнопедагогічної підготовки фахівців та є предметом особливої уваги держави, що відображено в основних документах, які визначають пріоритети освітньої політики України: закони України «Про освіту», «Про вищу освіту», «Про національну програму інформатизації», державні програми «Інформаційні та комунікаційні технології в освіті і науці» на 2006-2010 роки, Концепція реалізації державної політики у сфері реформування загальної середньої освіти «Нова українська школа» на період до 2029 року, Концепція впровадження медіа освіти в Україні (2010 р.), Стратегія розвитку інформаційного суспільства в Україні (2013 р.) тощо.
МОНІТОРИНГ МОРФО-ФУНКЦІОНАЛЬНИХ ПОКАЗНИКІВ КВАЛІФІКОВАНИХ ГРАВЦІВ, ЩО СПЕЦІАЛІЗУЮТЬСЯ У РЕГБІ-7
Authors: КВАСНИЦЯ Олег , ТИЩЕНКО Валерія , КВАСНИЦЯ Ірина
Published: April 2023

У роботі представлені дослідження науковців, які  характеризуються концентрацією уваги на процесі підготовки спортсменів, що спеціалізуються у регбі-7. Сучасні напрацювання дають можливість стверджувати, що такі морфологічні показники, як розміри тіла, склад та маса тіла, є важливими складовими оцінювання підготовленості спортсменів до змагань, а також відбору до спортивної команди. Мета статті полягала у теоретичному та експериментальному дослідженні значущості морфологічних показників кваліфікованих регбістів команди «Поділля» (м. Хмельницький) як інформативного показника керування тренувальним процесом гравців різних ігрових амплуа у регбі-7. Для досягнення поставленої мети було проведено педагогічне  дослідження антропометричних показників та складу тіла спортсменів. Використовувались інструментальні методи визначення складу тіла біоімпедансним методом на вагах-аналізаторах «TANITA–RD545». У дослідженні брали участь 12 спортсменів, які є провідними гравцями команди «Поділля» (м. Хмельницький). У ході дослідження виявлені відмінності, пов’язані з антропометричними показниками гравців команди залежно від позиції, яку спортсмен займає в грі: нападники зазвичай вищі та мали більшу масу тіла, на відміну від захисників. Водночас, морфологічні показники, отримані в ході тестування спортсменів свідчать, що індекс маси тіла (ІМТ) у 86% спортсменів знаходиться в межах фізіологічної норми, у 14% – дещо вищий від нормальної фізіологічної норми.

Аналіз компонентного складу тіла регбістів, свідчать, що вміст жирової тканини був вищим у нападників, але перебував у межах фізіологічної норми у відповідності до антропометричних даних спортсменів або наближався до найвищої позначки норми. Вміст м’язової тканини статистично також вищий у форвардів. У всіх спортсменів вміст води є в межах фізіологічної норми. У нашому дослідженні встановлено, що більша вага форвардів супроводжувалася більшим вмістом маси жиру в тілі спортсменів. Зазначимо, що відсоток жирової маси регбістів команди «Поділля» (м. Хмельницький) був вищим за показники гравців клубних команд Нової Зеландії, Австралії та Іспанії. У ході педагогічного дослідження доведено значущість морфологічних показників для моніторингу стану спортсменів у регбі-7 в залежності від ігрових амплуа.
ОСОБЛИВОСТІ ПРОФІЛАКТИКИ СОЦІАЛЬНОГО СИРІТСТВА
Authors: РІДКОДУБСЬКА Ганна
Published: April 2023

В праці представлено теоретичний аналіз наукових джерел на вирішення проблеми профілактики соціального сирітства. В роботі представлено сучасна інтерпретація дефініції «профілактика», зміст цього визначення стає багатовимірним, і використовуються для позначення різних напрямів політики, групової та індивідуальної взаємодії. В праці розкрито теоретичні та практичні особливості розробки та здійснення профілактики соціального сирітства в сучасних умовах воєнного конфлікту. Українська система соціальної профілактики – трирівнева модель, здійснення попереджальних заходів первинної, вторинної і третинної профілактики.

Проаналізовано сучасну практику роботи соціального працівника щодо зниження кількості соціальних сиріт та розкрито сутність найдієвіших з них. В роботі визначено пріоритетні завдання профілактики соціального сирітства та охарактеризовано різні рівні взаємодії освітнього, соціально-політичного та суспільного середовищі під час реалізації основних моделей профілактики. В процесі профілактики соціального сирітства, залишаються актуальними питання забезпечення ефективності діяльності суб'єктів соціальної роботи щодо раннього виявлення сімей, які опинилися у складних життєвих обставинах, надання їм соціальних послуг, попередження вилучення дитини із сім'ї, зокрема розроблення комплексних соціальних послуг для цієї категорії сімей та впровадження нових технологій соціальної роботи з ними.
АНАЛІЗ СУЧАСНИХ ПРОБЛЕМ ТА ПЕРСПЕКТИВ РОЗВИТКУ ФІЗИЧНОЇ КУЛЬТУРИ ТА СПОРТУ ДЛЯ ДОРОСЛОГО НАСЕЛЕННЯ В УКРАЇНІ ТА КРАЇНАХ ЄВРОПИ
Authors: КАРАБАНОВ Євген , ОСІПОВ Віталій
Published: April 2023

В статті представлено результати аналізу сучасних проблем та перспектив розвитку фізичної культури та спорту дорослого населення в Україні та країнах Європи
У статті наведені результати досліджень, що демонструють зменшення рівня фізичної активності серед дорослого населення та його негативний вплив на здоров'я. Також розглянуті проблемні аспекти забезпечення доступу до спортивної інфраструктури та пропаганди фізичної активності для дорослих у різних країнах Європи, включаючи Україну. В статті висвітлено ключові питання такого аналізу, а саме: здоров'я дорослого населення, соціальні переваги, проблеми доступності, розвиток спортивної інфраструктури, розширення спектру спортивних занять, перспективи розвитку фізичної культури та спорту. За даними Європейського центру з профілактики та контролю захворювань (ECDC) за 2019 рік, Україна має високу частку померлих від серцево-судинних захворювань (46,6% від усіх померлих) та раку (18,4% від усіх померлих). Автори статті наголошують на необхідності розвитку національної та міжнародної політики з питань спорту та фізичної культури для дорослих, підвищенні ефективності програм та заходів, що спрямовані на популяризацію фізичної активності та збереження здоров'я населення. Є багато ініціатив в Європейському Союзі, які підтримують фізичну активність та спорт дорослого населення. Наприклад, ініціатива "European Week of Sport" сприяє підвищенню свідомості про значення фізичної активності та спорту в щоденному житті, а також стимулює людей до більш активного способу життя. У Європейському Союзі існує приблизно 300 тисяч спортивних клубів. У Європі існує багато спеціалізованих центрів для проведення тренувань та підготовки спортсменів: Національний центр спортивної підготовки в Клермон-Феррані, INSEP Франція Національний центр спортивної підготовки в Біспінгені, Німеччина. Національний центр спортивної підготовки "Стейплфорд" (The National Sports Centre at Bisham Abbey) в Кембриджі, Великобританія. В цілому, стаття містить важливу інформацію для тих, хто займається проблемами здоров'я та фізичної активності серед дорослого населення.
Evaluation of Türkiye's glacier tourism potential with multi-criteria decision-making (MCDM) techniques
Authors: ZORLU Kuttusi , DEDE Volkan
Published: April 2023

Glacier tourism, a recent trend, has been successfully applied in many glacial areas. Although Türkiye has significant potential regarding these resources, it is still unfamiliar with 'glacier tourism'. The current study evaluates the glacier tourism potential of 12 regions that correspond to the current glacial areas of Türkiye using CRITIC-ARAS-WASPAS techniques. For this purpose, 18 criteria obtained from the literature were analysed with the help of an expert panel and various secondary data. According to the findings, the regions with the most significant potential for glacier tourism development in Türkiye are Rize, Mersin, Hakkari, Artvin, Kayseri, and Niğde. Various suggestions were presented to the stakeholders for the development and expansion of glacier tourism in these regions. The study and the proposed methodology are expected to make theoretical contributions to the literature as they focus on a topic that has not been addressed before in Türkiye. The findings are also anticipated to provide practical knowledge and awareness to local stakeholders in the glacier areas.
Coğrafya öğretmen adaylarının arazi çalışmalarına hazırlık aşamalarının değerlendirilmesi
Authors: GÖKÇE GÜNDÜZOĞLU Hediye Arzu , ÇUKUR Hasan , OLCAY Hilal
Published: April 2023

Bu çalışmanın amacı, coğrafya öğretmen adaylarının arazi çalışmalarına nasıl hazırlandıklarını ortaya koymaktadır. Bu amaç doğrultusunda araştırma nitel araştırma yöntemlerinden eylem araştırma deseninde gerçekleştirilmiştir. Araştırmanın çalışma grubunu ise 2021-2022 eğitim öğretim yılı bahar döneminde Dokuz Eylül Üniversitesi Buca Eğitim Fakültesi, Coğrafya Eğitimi Anabilim Dalı’nda eğitimine devam eden 36 öğrenci oluşturmuştur. Araştırmada veri toplama aracı olarak 5 soruluk “yarı yapılandırılmış görüşme formu” kullanılmış olup verilerin analizinde MAXQDA 22.2.0 yazılımından yararlanılmıştır. Araştırmanın sonucunda beş tema ve bu temalarla ilişkili kodlara ulaşılmıştır. Bu temalar; “arazi çalışmalarına hazırlık süreci”, “arazi çalışmaları sırasında bulunması gereken ekipmanlar”, “arazi çalışması için güzergâh berlirleme”, “arazi çalışmaları sırasında bilgileri/gözlemleri/bulguları kaydetme”, “arazi çalışmalarının coğrafyayı öğrenmeye katkısı” şeklinde adlandırılmıştır. Araştırmanın güvenirliğini sağlamak için bir uzman görüşüne başvurulmuş olup hesaplamalarda Miles & Huberman (1994) tarafından geliştirilen formül kullanılmıştır. Bu formül doğrultusunda; birinci sorunun güvenirliği %88, ikinci ve üçüncü soruların güvenirliği %81, dördüncü sorunun güvenirliği %87, beşinci sorunun güvenirliği %92 ve tüm soruların güvenirliği %86 olarak hesaplanmıştır. Araştırmanın Çalışmanın sonucunda katılımcıların arazi çalışmalarının coğrafya eğitimine olumlu ve kalıcı bir katkı sağladığı, arazi çalışmalarına katılan bireylere coğrafi bakış açısı kazandırdığı konusunda görüş birliğinde oldukları saptanmıştır. Ayrıca katılımcıların %94’ünün arazi çalışmalarına hazırlıklı katıldığı tespit edilmiştir.
Searching patent information on the recovery of rare earth metals from electronic waste
Authors: Barbieri Massimo
Published: April 2023

Waste and electrical and electronic equipment (WEEE), which is generally disposed of in landfills, contains valuable elements, called rare earth metals, and they are applicable in many industrial sectors.

Only 1% of the rare earth elements are recycled from the residues mentioned above.

This study aims to show a patent landscape in recovering rare earth metals from end-of-life electronic equipment.

The patented methods were searched on the Orbit Intelligence platform (FamPat database), Espacenet, Google Patents and Octimine, using keywords and classification codes (IPC and CPC).

China is the country with the greatest number of priority patent applications filed in this technical field, followed by the USA and Japan.

The different techniques developed for recovering rare earth metals are hydrometallurgy, pyrometallurgy and biometallurgy or bioleaching. Hybrid treatments have been also patented.

A focus on the biological treatment technologies for recovery of rare earth metals from e-waste was carried out.
SECURE II: Unlocking the Potential of Artificial Intelligence for Entrepreneurial Success
Authors: Morandé Swapnil , Arshi Tahseen , Gul Kanwal , Amini Mitra
Published: April 2023

This study explores the potential of artificial intelligence (AI) in assisting novice entrepreneurs in evaluating the effectiveness of ex-ante measures of business model design and their impact on ex-post measures of performance. The study adopts a decision science approach to argue that entrepreneurs create business models by making choices based on what is valuable and possible rather than what is available. The Startup Evaluation Calculus with Research Evidence (SECURE I) framework has shown that the careful design of ex-ante measures can positively impact ex-post standards of firm performance. The study proposes a SECURE II framework integrating AI tools to improve the frameworks' predictive ability. By unlocking insights and patterns hidden in large volumes of data, AI can assist entrepreneurs in making informed decisions and becoming more responsive and agile to market needs. By unlocking patterns hidden in voluminous data, AI can assist entrepreneurs to predict Entrepreneurial Capability for making informed decisions and becoming more responsive and agile to market needs. The study's contributions include integrating Symbolic AI and Neural AI to aid entrepreneurial decision-making, enhancing the cognitive capacity of decision-making, and using an evaluation tool that incorporates automation and persuasiveness. The research relies on quantitative data and uses an experimental method to examine the effects of AI on entrepreneurial decision-making.
Apego parental y riesgo de suicidio en mujeres colombianas: el papel del poder y la violencia en el noviazgo
Authors: Gracia Leiva Marcela , Ubillos Landa Silvia , González Castro José Luis , Puente Martínez Alicia , Arias Rodríguez Gina
Published: April 2023

La violencia en el noviazgo (VN) es un problema social con serias consecuencias en las víctimas. Los estudios sobre factores protectores de la VN contra las mujeres en Colombia son escasos. Por ello, este estudio examina la relación entre el apego parental y el riesgo de suicidio (RS), y el papel mediador del poder en la relación y la VN en 210 estudiantes colombianas (adolescentes: 13-18 años; adultas emergentes: 19-24 años). Los resultados evidencian que un 89,55% habían experimentado VN, y un 55,2% habían tenido ideas suicidas. Las adolescentes muestran mayor poder, mayor RS y menos apego parental que las adultas emergentes. En todas las participantes mayor apego parental se asocia con un menor RS. El análisis de mediación serial encuentra un efecto indirecto significativo para el apego parental sobre el RS a través del poder y la VN (B = -0,031, SE= 0,015, IC95 %: -0,063/-0,005). Una relación de calidad con los padres/madres podría derivar en un mayor poder de las jóvenes en sus relaciones de pareja, mermando la probabilidad de sufrir VN y RS. Por tanto, es importante reforzar el rol parental en la promoción del empoderamiento de sus hijas con el fin de disminuir la VN y sus consecuencias en la salud mental.
Inhibitors of α-glucosidase and Angiotensin-converting Enzyme in the Treatment of Type 2 Diabetes and its Complications: A Review on in Silico Approach
Authors:   Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria., Kehinde Oyedele Abdul-Quddus , Damilare Boyenle Ibrahim ,   Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria., Ogunlana AbdeenTunde ,   Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria., Ayoola Ashiru Mojeed ,   Department of Chemical Sciences, College of Natural and Applied Science, Fountain University, Osogbo, Nigeria., Opeyemi Emmanuel Atanda ,   Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria., Temitope Isaac Adelusi ,   Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Published: April 2023

Background: The use of pharmacological agents to synergistically target key enzymes associated with carbohydrate digestion (α-glucosidase) and the hypertension-related angiotensin-converting enzyme (ACE) are critical strategies for the management of type 2 diabetes (T2D) and its end-stage complications. Furthermore, aside from their blood pressure-lowering effect, ACE inhibitors (ACEIs) are important therapeutic agents for preventing diabetic complications, highlighting their synergistic renoprotective and antihypertensive effects in diabetic patients who are normotensive and hypertensive. Objectives: We reviewed the safety and potent activity of phytochemicals discovered based on molecular docking and dynamics in recent years that could be used to treat T2D. Methods: We surveyed recently in silico drug discovery findings on α-glucosidase and ACE retrieved from the PubMed database. Computational in silico ADMET meta-analysis was performed on 57 compounds that could potentially inhibit α-glucosidase or ACE. Results: The review highlighted the fact that most hit compounds of α-glucosidase and ACE involving the use of molecular docking and molecular dynamics techniques are competitive and peptide inhibitors, respectively. Moreover, we found that most authors do not consider absorption distribution metabolism excretion toxicity (ADMET) studies on drug candidates, which is important in determining the safety profile of potent leads. Hence, we performed in silico ADMET meta-analysis of the reported compounds and found some inhibitors with an excellent pharmacological profile. Conclusion: We propose that further studies be conducted on these promising leads to demonstrate their efficacy and safety in the treatment of T2D.
In Vitro Antibacterial Activity of Ethanolic Extract of Neem Leave (Azadirachtaindica Linn) Against Clinical Isolates
Authors:   Department of Microbiology, Government Medical College, Datia, India., Mehta Abhishek , Jain Arti ,   Department of Microbiology, Government Medical College, Vidisha, India., Saxena Gaurav ,   Department of Microbiology, Government Medical College, Ratlam, India.
Published: April 2023

Background: Emerging multidrug resistance amongst pathogens is making the choice of antibiotics for the management of infections extremely difficult and threatens the return of the pre-antibiotic era in healthcare settings. To tackle this menace, there is a growing need for exploring bioactive compounds derived from herbal extracts, which could be incorporated as alternative therapeutic agents in the antimicrobial therapy of such infections. Objectives: We evaluated the antibacterial activity of ethanolic extracts of Neem leaves against standard ATCC strains and the pathogens isolated from clinical specimens. Methods: This cross-sectional study was undertaken to assess in vitro antibacterial activity of different concentrations of ethanolic Neem extract against three ATCC (American-type culture collection) strains and 63 clinical isolates using the disk diffusion method. The minimum inhibitory concentration (MIC) of the extract against test isolates was determined by the Broth dilution method. Results: Neem extract exhibited the highest antimicrobial activity toward Escherichia coli ATCC-25922 followed by Staphylococcus aureus ATCC-25923 and Pseudomonas aeruginosa ATCC-27853 strains. Amongst the Gram-positive isolates, the extract exhibited significantly high antibacterial activity against S. aureus and Enterococcus spp. Amongst the Gram-negative isolates, high antibacterial activity was seen against E. coli followed by Klebsiella pneumoniae and Proteus mirabilis. In this study, the lowest MIC values were observed against E. coli followed by S.aureus, P. mirabilis, and K. pneumoniae. The highest MIC values of the extract were observed against non-fermenters, like P. aeruginosa and Acinetobacter spp. isolates. Conclusion: This study strongly depicts that the ethanolic extract of Neem leaves exhibits significant antibacterial activity not only against the standard ATCC strains but also against various clinical isolates
A Novel Methodology for Human Plasma Protein Binding: Prediction, Validation, and Applicability Domain
Authors:   Laboratory of Biomaterial and Transport Phenomena, University of Médéa, Médéa, Algeria., Khaouane Affaf , Ferhat Samira ,   Laboratory of Biomaterial and Transport Phenomena, University of Médéa, Médéa, Algeria., Hanini Salah ,   Laboratory of Biomaterial and Transport Phenomena, University of Médéa, Médéa, Algeria.
Published: April 2023

Background: Plasma protein binding is a key component in drug therapy as it affects the pharmacokinetics and pharmacodynamics of drugs. Objectives: This study aimed to predict the fraction of plasma protein binding. Methods: A quantitative structure-activity relationship, convolutional neural network, and feed-forward neural network (QSAR-CNN-FFNN) methodology was used. CNN was used for feature selection, which is known as a difficult task in QSAR studies. The values of the descriptors acquired without the preprocessing procedures were rearranged into matrices, and features from a deep fully connected layer of a pre-trained CNN (ALEXNET) were extracted. Then, the latest features learned from the CNN layers were flattened out and passed through an FFNN to make predictions. Results: The external accuracy of the validation set (Q2=0.945, RMSE=0.085) showed the performance of this methodology. Another extremely favorable circumstance of this method is that it does not take a lot of time (only a few minutes) compared to the QSAR-Wrapper-FFNN method (days of hard work and concentration) and it automatically gives us the characteristics that are the best representations of our input. Conclusion: We can say that this model can be used to predict the fraction of human plasma protein binding for drugs that have not been tested to avoid chemical synthesis and reduce expansive laboratory tests.
Assessment of the Knowledge and Quality of the Practice of Proper Foot Care in Iranian Patients With Type 2 Diabetes
Authors:   Department of Clinical Pharmacy, Faculty of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran, Ghayoumi Faraz , Radfar Mania ,   Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Mohajeri Tehrani Mohammad Reza ,   Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Monajati Mahila ,   Department of Internal Medicine, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Published: April 2023

Background: Uncontrolled diabetes can lead to a high rate of complications. Diabetic foot ulcer (DFU) leads to significant morbidity. However, DFU can be prevented and managed through foot care education for patients. Objectives: The current study aimed to evaluate the knowledge and practice routines of patients with type 2 diabetes (T2DM) regarding foot care. Methods: A questionnaire was designed to obtain patients’ demographic data, evaluate their risk for a foot ulcer, and assess their level of knowledge and practice about daily foot care. After confirming the validity and reliability of the questionnaire, 200 T2DM patients were interviewed. Results: The mean age was 61.1±11.7 years, and 64% were males. Forty-five percent of patients were previously educated regarding foot care. More than 50% of patients answered questions correctly. Calculations demonstrated the mean score of knowledge and practice as 6.3±2 (out of 11) and 14.2±3.4 (out of 20), respectively. There was no correlation between the patient’s age, gender, or history of previous DFU and their knowledge and practice level. However, patients’ higher level of education or employment status was associated with a higher level of knowledge and practice than their other respective groups. Conclusion: In this study, patients had a medium to low level of foot care knowledge and a medium to a high level of daily foot care practice. However, these results also emphasize the importance of the need for organized and structured educational programs for diabetic patients regarding diabetic foot care.
COMPARATIVE ANALYSIS OF ANTI-CORRUPTION MECHANISMS IN UKRAINE AND EUROPEAN COUNTRIES
Authors:   Territorially Separate Branch  «Kamianske Branch of the Academy of the State Penitentiary Service»,  Kamianske, Ukraine, Didenko О.V.
Published: April 2023

This article is devoted to the study of the experience of other countries of the world, in particular European countries, in anti-corruption methods and the possibility of their application in Ukraine. The concept of corruption is international, there is not a single country that does not face this phenomenon and does not try to counteract it. The article provides a comparative analysis of anti-corruption activities in countries such as Poland, Germany, Great Britain, the Netherlands, and Ukraine. It is found that the positive experience of European countries in the activity against corruption is a confirmation that when solving the relevant problem, it is necessary to use a comprehensive approach and a principled administrative and legal position. It is established that European countries have developed and adopted special anti-corruption laws, as well as created certain effective organizations, some of which work not only at the local government level, but at the international level. In Ukraine, as well as in other countries, special laws have been created that are aimed at anti-corruption. It is stated that European countries have developed and approved special laws aiming at anti-corruption activity, as well as created particularly effective organizations which work not only at the local level, but also at the international one. The country is actively creating an anti-corruption strategy to prevent corruption activity. It is analyzed that Ukraine needs to speed up the process of euro integration which will help to come closer to entering the international anti-corruption bodies. International anti-corruption experience will allow Ukraine to achieve transparency in corruption and pave the way to its decrease. It is emphasized that hard work on preventive measures against corruption is effective in European countries that is extremely necessary for implementation in Ukraine to prevent corrupt offenses. Fruitful work on anti-corruption measures will lead to a decrease in corrupt practices in any field. Key words: corruption, anti-corruption activity, strategy, Ukraine, European countries, international experience.