bluuebunny/crossref_metadata_2025 huggingface dataset:
Lack of Causal Roles of Cannabinoid and Dopamine Neurotransmitter Systems in Orbitofrontal and Piriform Cortex in Fentanyl Relapse in Rats
Authors: Claypool Sarah M. , Behdin Sana , Applebey Sarah V. , Orihuel Javier , Ma Zilu , Reiner David J.
Published: June 2022

The orbitofrontal cortex (OFC) and piriform cortex (Pir) play a role in fentanyl relapse after food choice-induced voluntary abstinence, a procedure mimicking abstinence because of availability of alternative nondrug rewards. We usedin situhybridization and pharmacology to determine the role of OFC and Pir cannabinoid and dopamine receptors in fentanyl relapse. We trained male and female rats to self-administer food pellets for 6 d (6 h/d) and intravenous fentanyl (2.5 µg/kg/infusion) for 12 d (6 h/d). We assessed fentanyl relapse after 12 discrete choice sessions between fentanyl and food (20 trials/d), in which rats voluntarily reduced fentanyl self-administration. We used RNAscope to determine whether fentanyl relapse is associated with activity (indicated byFos) in OFC and Pir cells expressingCnr1[which encodes cannabinoid 1 (CB1) receptors] orDrd1andDrd2(which encode dopamine D1 and D2 receptors). We injected a CB1 receptor antagonist or agonist (0.3 or 1.0 µg AM251 or WIN55,212-2/hemisphere) into OFC or a dopamine D1 receptor antagonist (1.0 or 3.0 µg SCH39166/hemisphere) into Pir to determine the effect on fentanyl relapse. Fentanyl relapse was associated with OFC cells co-expressingFosandCnr1and Pir cells co-expressingFosandDrd1. However, injections of the CB1 receptor antagonist AM251 or agonist WIN55,212-2 into OFC or the dopamine D1 receptor antagonist SCH39166 into Pir had no effect on fentanyl relapse. Fentanyl relapse is associated with activation ofCnr1-expressing OFC cells andDrd1-expressing Pir cells, but pharmacological manipulations do not support causal roles of OFC CB1 receptors or Pir dopamine D1 receptors in fentanyl relapse.
Franz Metzner a Liberecko
Authors: Mohr Jan
Published: June 2022

The article, written on the occasion of the 150th anniversary of the birth of the German-Czech sculptor Franz Metzner (November 18, 1870), focuses on Metzner‘s ties to northern Bohemia and Liberec, his sculptural and personal ties to the local environment. The text is accompanied by an edition of Metzner‘s correspondence, which draws from the surviving copiers from 1906–1918, stored in the Germanisches Nationalmuseum in Nürnberg, Abteilung Deutsches Kunstarchiv. In addition to mentions of the Liberec fountain, a number of letters has been preserved on the creation of a monument to Heinrich von Liebieg for Liberec, which finally not realized. The only work done for the Liberec (Reichenberg) region and the Frýdlant (Friedland) region, respectively, was a hundred-circle portrait relief for the monument to Emperor Joseph II, created in 1912 and lost today. In this context, the Raspenava (Raspenau) painter Franz Wenzel Jäger, Metzner‘s longtime friend, also plays an important role, to whom letters concerning non-artistic matters are also attached.
Robert Bellah’s Legacy in Time of Trial
Authors: Goldberg Chad Alan
Published: June 2022

Matteo Bortolini’s biography of Robert Bellah, A Joyfully Serious Man, is a rich and stimulating treatment of one of the greatest sociological thinkers of the twentieth century. As such, it is bound to raise questions about the interpretation of Bellah’s life, changes in his thinking over time, and the relevance of Bellah’s ideas to current concerns. Three questions are raised here. The first question concerns the role of Freudian psychoanalysis in biographical work. A second question concerns the role of individualism in American culture, which was an enduring concern for Bellah. A third and final question concerns the implications of Bellah’s ideas, nearly a decade after his death, for our current political conjuncture.
Representative range of acoustic point source measurements in the Chukchi Sea
Authors: González Silvana , Horne John K. , Danielson Seth L. , Lieber Lilian , López Guzmán
Published: June 2022

The use of stationary, active acoustics provides an effective approach to characterize and monitor temporal variability in the abundance and behavior of pelagic organisms, especially in seasonally ice-covered waters of high latitude marine ecosystems. However, point measurements from stationary echosounders are limited in their spatial coverage. A quantification of the spatial area represented by point measurements (i.e., representative range) is required to ensure effective biological characterization and monitoring. Here, concurrent mobile and stationary active acoustic data collected during summers of 2015 and 2017 are used to assess the representative range of fish and zooplankton density measurements from the Chukchi Ecosystem Observatory located at Hanna Shoal, Northeast Chukchi Sea. Six methods used to calculate representative ranges of backscatter means and variances resulted in representative ranges between approximately 0.3 and 86 km, depending on the year and calculation method. Such relatively large representative ranges reflect the tight bio-physical associations and large characteristic environmental length scales of the NE Chukchi Sea. Between years, up to 10-fold variations in representative ranges were attributed to interannual changes in water mass characteristics and associated species assemblages. Differences of 1–2 orders of magnitude in our calculated ranges among methods are attributed to differences in the rationale and associated assumptions of each approach. The choice of method and resulting representative range depends on monitoring goals: detection of change, mapping of spatial distributions, characterization of spatial variance, or interpolation of temporal variability over space. Our comparison of stationary acoustic to mobile surveys extends the understanding of spatiotemporal variability of marine organism distributions in the NE Chukchi Sea and informs cost-effective design of observing systems to monitor and predict impacts of environmental change.
Improving glycaemic management in people with diabetes on maintenance haemodialysis
Authors: Kuverji Apexa , Reed Jo , Sawhney Harpreet , James June , Gregory Rob , Burton James , Frankel Andrew
Published: June 2022

The Diabetes Care in Haemodialysis (DiH) working group aims to improve the care of people with diabetes mellitus on the haemodialysis unit by supporting the implementation of the 2016 JBDS guidelines. In order to support the implementation of the guideline recommendations the DiH working group have established a set of standards, developed an audit tool to demonstrate adherence to standards, and have developed educational support for haemodialysis staff both online and delivered face-to-face.
We publish audit findings from five distinct haemodialysis units, highlighting the impact of the educational programme on the achievement of guideline standards. We also report the impact of the COVID-19 pandemic on diabetes care and quality improvement.
Education Cash Transfer and High School Enrollment in Indonesia
Authors: Caniago Pasman , Elfindri Elfindri , Sari Delfia Tanjung
Published: June 2022

Smart Indonesia Program (Program Indonesia Pintar/PIP) is a policy made by the Indonesian government that aims to guarantee and ensure every child has access to a decent education and has the same learning opportunities at all levels of education. However, the enrollment rate at the secondary level, especially in senior high school, is still far from the government target, as stated on the National Medium-Term Development Plan of 2015-2019. This study aims to understand the PIPâ€™s impact on the probability of getting an education in Indonesia's Senior High School (Sekolah Menengah Atas/SMA). This study applied logistic regression analysis to determine PIP's effect regarding children's opportunities at the age of 16-18 years old to attend school. This study uses data from 16-18 years old children who belong to the households categorized as the 40% lowest expenditure group in Susenas 2017, to align with the PIPâ€™s target based on Integrated Database (Basis Data Terpadu /BDT). The result reveals that 16-18 years old children in households included in the lowest 40% of expenditure who receive PIP have higher and significant probabilities of attending high school level in Indonesia. Administration of PIP to 16-18 years old children from the 40% lowest expenditure group will increase their chance to participate in senior high school/equivalent by 15-25 percent. The characteristics of the beneficiaries such as gender, education level of the head of the household, and residence area can affect PIP's performance in escalating the probability of 16-18 years old children attending senior high school/equivalent.
The Impact of Asian Games 2018 on Indonesian Economy
Authors: Prasetyo Epson , Ariutama I Gede Agus , Saputra Acwin Hendra
Published: June 2022

Organizing the 18th Asian Games 2018 in Indonesia, specifically in DKI Jakarta, South Sumatra, West Java, and Banten spent a large amount of state and regional budget (APBN and APBD), which was more than Rp10 trillion in the 2018 fiscal year. The government policy to host the mega event and expend a large amount of budget in terms of government consumption and investment was expected to have an impact on the Indonesian economy, both directly and indirectly. Thus, this study aims to identify the impact of government expenditure using the 2010 Input-Output table issued and updated by the Central Bureau of Statistics in July 2019 with 17 sectors. The study found that the multiplier effect on the economy is greater than government expenditure with the manufacturing sector being the most affected sector by government spending with a value of six point seven trillion rupiah. In addition to the multiplier effect, this study also calculates the estimated Value Added Tax of government spending. The result of the estimated Value Added Tax potential is one point sixty one trillion rupiah. It can be concluded that the Asian Games 2018 brought positive impact on economy and government revenue in the form of taxation.
Fiscal Illusion and Asymmetric Response of Regional Financial Performance
Authors: Pentury Marthen Anthon , Orisu Lillyani Margaretha , Kareth Martha A.C.
Published: June 2022

Purpose of this research is to prove whether there is a fiscal illusion in the regional financial performance of districts/cities in West Papua and to capture asymmetric response of regional spending. Period in this research from 2010-2019 in West Papua Province which consists of nine districts/cities considering the availability of data, data sources from the Central Statistics Agency (BPS) and the Ministry of Finance (KEMENKEU) Dependent variable is regional financial performance as measured by regional spending and independent variable consists of general allocation funds, special autonomy funds, regional gross domestic product, population, local taxes, local retribution and dummy variables. Analysis methods is panel data regression fixed effect approach, fiscal illusion detection refers to the model developed by Borcherding and Deacon, and response asymmetry refers to the Gennari and Messina model. Findings/Originality: Proving the existence of fiscal illusions and asymmetry responses in a panel data model, results show that there are fiscal illusions in the regional financial performance of districts/cities in West Papua Province as seen from the negative and significant correlation of regional spending with local taxes. There is an asymmetrical response to regional spending in increasing the balancing fund, seen from the negative and significant dummy variable value in the model.
Programa preventivo de lesión de ligamento cruzado anterior en fútbol femenino durante períodos de confinamiento
Authors: Calvo-Fernández Yonathan , Lago-Rodríguez Ángel
Published: June 2022

La pandemia por COVID-19 obligó a paralizar el deporte en todo el mundo; por lo tanto, se redujo la carga de trabajo de los deportistas, lo cual, sumado al probable aumento de la densidad competitiva tras el período de confinamiento, resultará en un incremento del riesgo de lesión después del retorno a la competición. A este respecto, la rodilla es una de las zonas con mayor prevalencia de lesión en el fútbol femenino y la lesión del ligamento cruzado anterior (LCA) es de las más frecuentes y graves. En consecuencia, el objetivo del presente trabajo fue desarrollar un plan de prevención de lesión de LCA que pudiera ser llevado a cabo por mujeres futbolistas, durante períodos de confinamiento. Luego de una revisión de la literatura, se ha encontrado que el entrenamiento de fuerza (especialmente de la cadena posterior), el trabajo de la técnica de aterrizajes, así como el de estabilidad lumbopélvica y flexibilidad se asocian con un menor riesgo de lesión de LCA en mujeres. El programa se centra en factores de riesgo modificables, por lo que debe servir como una guía susceptible de adaptaciones, en función de cada contexto: las características individuales, el estado inicial y la evolución del sujeto durante su desarrollo. Por ende, en este estudio se plantea una intervención que pretende disminuir la probabilidad de lesión de LCA en mujeres futbolistas, tras el confinamiento, incidiendo, para ello, de forma directa sobre los mecanismos de lesión de LCA reportados en ellas.
A Proposal of Speed Zone Classification in Basketball: A New-Criteria Based on Maximum Registered Values
Authors: Rojas-Valverde Daniel , Gómez-Carmona Carlos , Rico-González Markel , Pino-Ortega José
Published: June 2022

The quantification of training load has become mandatory for coaches and team staff. Within the analyzed variables, distance covered at different speed zones is one of the most studied. However, there is no consensus in the definition of speed zones in the published articles about each team sport, so it makes difficult a comparison between them. Therefore, the purposes of this article were to establish a criteria standard in the classification of speed zones in team sports and to analyze its practical application in basketball. Five speed categories were established for basketball following the methodology described above: 0-10km/h, >10-13.8 km/h, >13.8-17.6 km/h, >17.6-21.5 km/h, and >21.5 km/h. The results showed differences between periods in high-speed displacements and sprints, maximum speed, total decelerations, and accelerations. In conclusion, the categorization of workload based on standard deviation according to maximum speed could be a viable option to individualize the analysis of distance covered per speeds in team sports such as basketball. Its use may lead to a better understanding and contextualization of the locomotion data in specific sports and teams.
Circo en la escuela: compartiendo prácticas pedagógicas
Authors: Tanasovici Cardani Leonora , Santos Rodrigues Gilson , Ontañón Barragán Teresa , Bortoleto Marco A C
Published: June 2022

Introducción: El circo atrae cada vez más la atención de profesionales de áreas diversas, entre ellos el profesorado de Educación Física que actúan en el ámbito de la Educación Básica. De hecho, numerosos estudios discuten la enseñanza de las actividades circenses en la escuela, mostrando que la experiencia de cada docente revela un camino posible para entender mejor esta aproximación. El objetivo de este estudio fue investigar la introducción de la enseñanza de actividades circenses en dos escuelas brasileñas de Educación Básica. Procedimientos metodológicos: El estudio de campo se realizó en dos instituciones brasileñas, una en la ciudad de Itatiba-SP y otra en Belo Horizonte-MG, por medio de observaciones directas y entrevistas en profundidad. Resultados y discusiones: En ambos casos la figura de la persona docente aparece como principal responsable por la inclusión del circo en la escuela y las actividades desarrolladas se justifican por considerar que contribuyen a una educación corporal más expresiva y artística. Consideraciones: Nos parece que las propuestas pedagógicas estudiadas pueden inspirar a otros docentes, gestores o investigadores en ese campo específico de actuación profesional.
Sobre verracos vettones. Nuevas esculturas zoomorfas de la Edad del Hierro en la meseta occidental
Authors: Manglano Valcárcel Gregorio R. , Ruano Lucía , García-Giménez Rosario , Berrocal-Rangel Luis
Published: June 2022

El patrimonio arqueológico, lejos de ser estable o permanente, es susceptible de cambios y modificaciones por agresión, incuria o desidia, lo que desgraciadamente no es infrecuente; aunque otras veces se incremente por la aparición o recuperación de piezas desconocidas o que se daban por desaparecidas y que afortunadamente han pasado a ver nuevamente la luz, a engrosar los correspondientes inventarios. Tal es el caso de las esculturas zoomorfas célticas conocidas como verracos, cuyo catálogo pretende actualizarse con el presente trabajo habida cuenta del aumento de su cantidad y de la diversificación de su procedencia. Las grandes áreas de distribución de estas esculturas comprenden una serie de provincias entre las que destacamos aquellas que, en su ámbito, han venido a arrojar los siguientes nuevos ejemplares: Ávila 20, Cáceres 6, Salamanca 3 y Toledo 1. La mayoría son toros situados en el Valle Amblés, centro de la cultura que los produjo, mientras que el resto, cerdos o jabalíes, se localizan principalmente en la cuenca del río Tajo. También se incluyen otros ejemplares rechazados o todavía sin confirmar.
El tesorillo tardorromano de la cueva de La Cuesta de Berció (Grado, Asturias). Primeras valoraciones en su contexto cantábrico
Authors: Fanjul Peraza Alfonso , Juaneda Gavelas Antonio , García Flórez Roberto , Ceballos Hornero Alberto , Muñóz Fernández Emilio , Llamosas San Miguel Carmen
Published: June 2022

En abril de 2021 se localizó y rescató mediante una pequeña intervención arqueológica de emergencia financiada por la Consejería de Cultura del Principado de Asturias, el que hasta el momento constituye el mayor tesorillo romano en cueva del norte de España. Se trata de un conjunto de 209 piezas entre los siglos III y V d.C., la gran mayoría, depositadas de forma secundaria en un sumidero natural. Proponemos un momento de la tesaurización a partir de mediados del siglo V d.C., en consonancia con otros hallazgos vecinos como el de cueva Chapipi, que bien podrían estar en relación, con el momento de inestabilidad política que supone, o bien la expansión sueva hacia el interior del territorio astur-romano, o bien la propia transición al génesis del reino de Asturias. Estas primeras hipótesis generales, a falta de otros datos cronológicos que esperamos obtener en las próximas excavaciones, son producto de disponer únicamente del tesorillo como indicador cronológico, un fósil director poco fiable por la extensa perduración de la moneda de bronce bajoimperial.
Un tipo de copa de tradición indígena en cerámica común romana anaranjada procedente de Herrera de Pisuerga (Palencia, España)
Authors: Blanco García Juan Francisco , Pérez González Cesáreo
Published: June 2022

En este artículo vamos a estudiar un tipo de copa de gran esbeltez al disponer de un elevado fuste hueco apoyado sobre un amplio pie acampanado, que está fabricada en cerámica común romana de cocción oxidante, pero en la que aún es reconocible el peso de la tradición alfarera indígena, vaccea y celtibérica. Se trata de cuatro piezas halladas en Herrera de Pisuerga (Pisoraca), lugar en el que estuvo establecida la Legión IIII Macedónica en tiempos de Augusto, que muy posiblemente estén en relación con el consumo de vino. Al menos una de ellas, la nº inv. 699, procede de una de las estancias militares del Ala Parthorum, y está fechada a finales de la época Julio-Claudia (Nerón) o, más probablemente, dentro ya de la flavia
La Calidad de la Docencia Online en la Educación Superior: Un Nuevo Enfoque para su Medición
Authors: Ramírez-Hurtado José M. , Vázquez-Cano Esteban , Pérez León Víctor E. , Hernández-Díaz Alfredo G.
Published: June 2022

El uso de Internet y el desarrollo de las nuevas tecnologías han provocado importantes cambios en la enseñanza y en el aprendizaje de los estudiantes de educación superior. La pandemia provocada por la Covid-19 ha hecho que muchas universidades hayan tenido que transferir sus actividades presenciales a la docencia online. Por este motivo, el objetivo de este trabajo es medir la calidad de servicio de la docencia online que se ha impartido durante el período de la Covid-19. Para ello, se utiliza como metodología una variante del análisis de importancia-valoración (Gap-IPA), en el que las importancias se derivan mediante un modelo de ecuaciones estructurales. Los datos han sido obtenidos a partir de una muestra de 467 estudiantes de una universidad del sur de España, los cuales reciben docencia de modo presencial en circunstancias normales o habituales. Los resultados muestran que para mejorar la calidad de la docencia online hay que actuar prioritariamente sobre los siguientes aspectos: interacción entre los estudiantes, concentración durante las clases online, revisión de pruebas online, utilidad del sistema y diversidad de actividades de evaluación. Los resultados de este estudio permiten orientar a los responsables educativos en la correcta definición de sus estrategias.
POTENCIA MUSCULAR Y CINÉTICA DE LACTATO EN SANGRE ENTRE GENOTIPOS DE ACTN3
Authors: Güereca-Arvizuo J. , Hernández-Torres P. , Moreno-Brito V. , Sierra-Muñiz G. , Trejo-Trejo M. , Cervantes-Borunda M. , Ramos-Jiménez A.
Published: June 2022

En este trabajo se estudiaron las diferencias en la potencia muscular y la cinética de las concentraciones de lactato en sangre ([LA-]b) entre genotipos de ACTN3 durante la prueba anaeróbica de Wingate, (PAnW). Participaron 35 voluntarios (18-35 años) masculinos, sanos y físicamente activos. Se analizaron la potencia muscular, las concentraciones de [LA-]b y la actividad de la Lactato Deshidrogenasa (LDH). El gen ACTN3 se determinó a partir de ADN de glóbulos blancos en sangre periférica. Independientemente del peso y masa muscular de los participantes, los portadores del genotipo RR vs. RX y XX desarrollaron mayor potencia muscular durante la PAnW (p<0.05), lo cual sugiere una mayor capacidad en este genotipo para utilizar el sistema ATP-PC durante un ejercicio supramáximo. La cinética en la potencia muscular y en las concentraciones de [LA-]b fueron semejantes entre genotipos. La PAnW no fue suficiente para causar daño muscular observado por la concentración de LDH.
ACTIVACIÓN MUSCULAR DE LA EXTREMIDAD INFERIOR DURANTE LA CARRERA
Authors: Hernández-Stender C.L. , Molina-Rueda F. , Alguacil-Diego I.M.
Published: June 2022

El objetivo del presente estudio es comprobar las diferencias en los patrones de activación muscular de la extremidad inferior entre las distintas modalidades de carrera (velocidad, medio fondo y fondo) al aire libre, observando determinados parámetros de activación muscular y espacio-temporales en las fases de contacto inicial y despegue. Se obtuvo como resultados diferencias significativas en la actividad muscular del Bíceps Femoral, en la fase de contacto inicial entre mediofondistas y fondistas (p=0,02), y en determinadas variables espaciotemporales. Los resultados muestran la existencia de diferencias en los patrones de activación muscular de la extremidad inferior y en ciertos parámetros espaciotemporales durante la carrera al aire libre.
EDAD RELATIVA EN BALONCESTO U12 ESPAÑOL: ANÁLISIS DE LA ÚLTIMA DÉCADA
Authors: Díaz-Aroca A. , Arias-Estero J.L.
Published: June 2022

Los objetivos de este estudio fueron: (a) analizar el efecto de la edad relativa (RAE) en los jugadores que participaron en el Campeonato de España de Minibásquet durante la última década, y (b) determinar una posible relación entre RAE y la clasificación final de los equipos analizados. Los participantes analizados fueron todos los jugadores (n = 2268) de los 19 equipos participantes durante los años 2009-2018. Se dividió a los jugadores, según su fecha de nacimiento, en cuatro cuartiles y se agruparon a los 10 mejores equipos de la clasificación en tres categorías diferentes. Los resultados mostraron el RAE durante la última década (?2 = 380.57, P = .000). Los tres mejores equipos incluyeron un mayor número de jugadores nacidos en la primera mitad del año (83.40%, ?2 = 183.15, P = .000). En conclusión, el rendimiento en baloncesto U12 podría verse afectado por el RAE.
ACTIVACIÓN MUSCULAR EN CORREDORES CON EL SÍNDROME DE LA BANDA ILIOTIBIAL
Authors: Suárez-Luginick B. , Rueda-Ojeda J. , Collazo-García C.L. , Rodríguez-López E.S. , Otero-Campos A. , Navarro-Cabello E.
Published: June 2022

Esta investigación examinó las diferencias en la activación muscular en los músculos de la cadera y muslo en corredores y corredoras con y sin el síndrome de la banda iliotibial (SFBI). Se registró la actividad neuromuscular en 21 corredores durante la carrera (14 SFBI y 7 sanos). No se han encontrado diferencias significativas en la actividad muscular media entre los corredores y corredoras lesionados. Sin embargo, en el caso de las corredoras lesionadas, se han encontrado diferencias entre el vasto lateral y el tensor fascia lata, y entre el vasto lateral y el bíceps femoral (p<0,05 en ambos casos). En el caso de los corredores hombres lesionados, se han encontrado diferencias entre el glúteo mayor y el tensor fascia lata, y entre el glúteo mayor y el bíceps femoral (p<0,05 en ambos casos). Estos hallazgos proporcionan un mayor entendimiento de la lesión y ayudarían a un tratamiento más específico.
The combustion performance of medium density fiberboard treated with fire retardant microspheres
Authors: Sun Lichao , Wang Fengqiang , Xie Yanjun , Feng Jianwen , Wang Qingwen
Published: June 2022

Fire retardant particles (guanylurea phosphate and boric acid) with a morphological characteristic of large crystal or fine microsphere, were respectively applied to wood fibers to make medium density fiberboard (MDF). The effects of particle size of the fire retardant on the combustion performance of the resulting MDF samples were determined using a thermogravimetric (TG) analyzer and cone calorimeter (CONE). The scanning electron microscopy and laser particle size analysis showed that the microspheric particles of fire retardant had a mean size of approximately 20 µm, which was smaller than the crystal (260 um). rporation of the fire retardant either in the crystal or microsphere shape reduced the weight loss of the resulting MDF, as evidenced by the TG analysis and the CONE test; release rate and total amount of both the heat and smoke were apparently Treatments caused an increase in both the ignition time and charring ratio of the MDF. Compared with the fire retardant crystals, the fine microspheric particles exhibited greater ability in inhibiting the release of heat and smoke through the combustion processes.
Infinitely many sign-changing solutions for an elliptic equation involving double critical Hardy–Sobolev–Maz’ya terms
Authors: Wang Lixia , Zhao Pingping , Zhang Dong
Published: June 2022

In this paper, we consider the existence of infinitely many sign-changing solutions for an elliptic equation involving double critical Hardy–Sobolev–Maz’ya terms. By using a compactness result obtained in [C.H. Wang, J. Yang, Infinitely many solutions for an elliptic problem with double Hardy–Sobolev–Maz’ya terms, Discrete Contin. Dyn. Syst., 36(3):1603–1628, 2016], we prove the existence of these solutions by a combination of invariant sets method and Ljusternik–Schnirelman-type minimax method.
CYTOTOXIC, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF Peganum harmala L. EXTRACTS
Authors:   Laboratory of Characterization and Valorization of Natural Products, Faculty of Nature and Life Sciences, University El-Bachir El-Ibrahimi, Bord jBou Arreridj, Mounira Dehiri
Published: June 2022

Peganum harmala L., known as ′Harmel′, is a plant widely used in the traditional Algerian medicine. Aim. The purpose of this work is to study the antioxidant, antiproliferative and antimicrobial potential of Peganum harmala extracts. Methods. Colorimetric methods were used to quantify phenolic compounds, while the antioxidant activity was estimated in vitro using DPPH/ABTS radical scavenging assay, ferric reducing power, β-carotene bleaching assay, total antioxidant capacity, and ferrous iron chelating assay. The agar well diffusion and the broth microdilution method were used to evaluate the antibacterial activity and the MTT assay was used to test the cytotoxicity of the extracts. Results. The ethanolic extracts of Peganum harmala L. showed the highest polyphenols content and the potent antioxidant, gave a good activity against Gram + and Gram- bacteria and good antifungal effect and were more cytotoxic to the HeLa cell line. Conclusions. It is concluded that selected plants could be a potential source of bioactive compounds with antioxidant, antimicrobial and antiproliferative potential. Hence, it is indicated to further investigate this plant in vitro as well as in vivo for new drug discovery.
The Issues of Wa'ad IMBT in The Fatwa DSN MUI Based on Fiqhiyyah Rules
Authors: Rahman Muh Fudhail , Luhur Mujhid Budi
Published: June 2022

Abstract. This study discusses the concept and function of wa'ad in the DSN-MUI Fatwa No.85/DSN-MUI/XII/2012 concerning Wa'ad in Islamic Financial and Business Transactions, changing the contract from non-binding to binding nature. This study aims to analyze wa'ad law in IMBT in terms of its risks and benefits. This study uses data from the DSN-MUI Fatwa, Islamic jurisprudence, and other scientific papers. This study finds out that IMBT combines an ijarah contract (lease) with a sale-purchase contract or a grant. The ijarah contract, the sale, and the purchase contract are linked with an agreement. In principle, the legal status of fulfilling wa'ad in Islamic finance and business transactions is binding because it will provide benefits for the Islamic economic community, and there will be no financing problems. In the DSN-MUI fatwa, the concept of "Doing two lesser evils" is used in determining the fatwa regarding promises (wa'ad) in a transaction.Keywords: Wa'ad, IMBT, Binding Promise, Islamic Jurisprudence Abstrak. Kajian ini membahas tentang konsep dan fungsi wa’ad dalam Fatwa DSN-MUI No.85/DSN-MUI/XII/2012, yang diubah dari tidak mengikat menjadi mengikat. Penelitian ini bertujuan untuk mengetahui analisis hukum wa’ad dalam IMBT ditinjau dari sisi kemaslahatan dan risikonya. Metode yang digunakan dalam penelitian ini adalah metode yuridis normative, dengan data berupa Fatwa DSN-MUI, literatur Hukum Islam/Fiqh, dan karya ilmiah lainnya. IMBT merupakan gabungan antara akad ijarah (sewa) dengan akad jual beli atau hibah. Akad ijarah dan akad jual beli  diikat dengan janji. Pada prinsipnya status hukum pemenuhan janji (wa’ad) dalam transaksi keuangan dan bisnis syariah adalah mengikat karena akan memberikan manfaat bagi masyarakat ekonomi syariah dan tidak menimbulkan masalah pembiayaan. Pada fatwa DSN-MUI, konsep “Melakukan dua keburukan yang lebih ringan” digunakan dalam menentukan fatwa tentang janji (wa’ad) dalam suatu transaksi.  Kata Kunci: Wa'ad, IMBT, Janji Yang Mengikat, Aturan Fiqhiyyah
Determinants of Islamic Bank Share Price Fluctuation During the Covid 19 Pandemic:	The Case of BTPN Syariah Bank Shares
Authors: Lauda Farhan , Fitri Resfa , Hasanah Qoriatul
Published: June 2022

Abstract. The Covid-19 pandemic has caused a decline in the performance of the national economy. However, the share price of Islamic banks, especially the BTPN Syariah Bank (BTPS), has continued to grow. This study aims to identify and evaluate the variables affecting BTPS stock price fluctuation, using The Vector Error Correction Model (VECM). The results show that in the short term, only the Jakarta Composite Index variable had a significant effect on the stock price of BTPS. While in the long term, the variables of Price to Book Value (PBV), Trading Volume Activity (TVA), GDP, Bank Indonesia (BI) Reference Interest Rate, and the Jakarta Composite Index had a significant effect on BTPS stock price. Based on the Impulse Response Function (IRF) analysis, the stock price of BTPS responded negatively to shocks in GDP, TVA, and the exchange rate. Meanwhile, the shocks of Earning Per Share, PBV, BI Reference Interest Rate, and the Jakarta Composite Index were responded positively by BTPS share price. Based on the Forecast Error Variance Decomposition analysis, PBV gave the highest contribution in explaining the diversity of BTPS stock prices fluctuation.Keywords: Covid-19, BTPS Shares, VECM, Internal Factors, External FactorsAbstrak. Pandemi Covid-19 menyebabkan penurunan perekonomian nasional. Namun, harga saham bank syariah, khususnya saham PT. Bank BTPN Syariah (BTPS) tetap tumbuh. Penelitian ini bertujuan untuk mengetahui faktor yang memengaruhi perubahan harga saham BTPS, dengan metode Vector Error Correction Model (VECM). Hasil penelitian menunjukan bahwa dalam jangka pendek, hanya variabel Indeks Harga Saham Gabungan yang berpengaruh signifikan terhadap harga saham BTPS. Sementara pada jangka panjang, variabel Price to Book Value (PBV), Trading Volume Activity (TVA), PDB, Suku Bunga Acuan Bank Indonesia (BI), dan Indeks Harga Saham Gabungan berpengaruh secara signifikan terhadap harga saham BTPS.  Berdasarkan analisis Impulse Response Function (IRF), harga saham BTPS merespon negatif adanya guncangan PDB, TVA, dan nilai tukar. Sementara guncangan Earning Per Share, PBV, Suku Bunga Acuan BI, dan Indeks Harga Saham Gabungan direspon positif oleh harga Saham BTPS. Berdasarkan analisis Forecast Error Variance Decomposition, PBV memberikan kontribusi tertinggi dalam menjelaskan keragaman perubahan harga saham BTPS.Kata kunci: Covid-19, Saham BTPS, VECM, Faktor Internal, Faktor Eksternal
Overview of Halal Cosmetics in a Decade: A Bibliometric Analysis
Authors: Suryani Wan , Subri Irwan Mohd , Rafiki Ahmad , Tobing Fitriani , Hidayat Sutan Emir
Published: June 2022

This article applies bibliometric analysis to examine existing works and literature on Halal Cosmetics to explore the concept’s evolving journey since its emergence. This study applies bibliometric approaches such as citation, co-citation, and co-occurrence of author keywords based on a bibliometric analysis of 137 publications extracted from the Scopus database between 2004 and September 2021. This research examines and elaborates the kind and direction of research on Halal cosmetics undertaken over the last few decades. It also identifies the most influential writers, journals, institutions, and countries concerning Halal cosmetics. This study might provide academics and practitioners with detailed insights into the Halal cosmetics concepts, which can subsequently be used as a reference for strategic efforts. AbstrakArtikel ini menerapkan analisis bibliometrik untuk mengkaji karya dan literatur yang ada tentang kosmetik halāl untuk mengeksplorasi perjalanan konsep yang berkembang sejak kemunculannya. Penelitian ini menggunakan pendekatan bibliometrik seperti sitasi, co-citation, dan co-occurrence 137 publikasi yang diambil dari database Scopus antara tahun 2004 dan September 2021. Penelitian ini mengkaji dan menguraikan jenis dan arah penelitian tentang kosmetik halāl yang dilakukan selama beberapa dekade terakhir serta mengidentifikasi penulis, jurnal, institusi, dan negara paling berpengaruh tentang kosmetik halāl. Analisis SWOT singkat termasuk dalam penelitian ini. Kajian ini memberikan wawasan yang mendetail kepada akademisi dan praktisi tentang konsep kosmetik halāl, yang selanjutnya dapat digunakan sebagai referensi untuk upaya-upaya strategis.
Features and problems of customs control in the context of European integration
Authors: Красівський Орест , Товт Вікторія
Published: June 2022

The article considers the stages of formation of customs business and initial training integration processes of Ukraine in the European Union in the field of cross-border cooperation, settlement of border relations, development of a custom policy which is capable to ensure effective contacts of the parties etc. Also the article considers the definition of customs control in current legislation and done by scientists.

Investigated the main offenses during the implementation of customs control, which underestimate the effectiveness of this procedure and make it ineffective to perform their functions. The main problems of methodological inefficiency are given during ensuring the activities of customs authorities in the exercise of their powers, which has a negative influence on the quality, reliability and efficiency of their implementation tasks.

Carried out an analysis of the staffing of customs authorities, namely their qualifications, the quality of the organization of working conditions, the peculiarities of business trips and their payment, wages and others problems that hinder the effective work of regulatory authorities. Revealed the main tasks related to the formation of a new personnel policy in the customs authorities through improving of professional level of training of employees, organization of cooperation between regulatory authorities and educational institutions and providing the necessary methodological, practical and educational literature of persons who teach courses or undergo advanced training, etc.

Proposed ways of improving public administration by customs control in Ukraine in order to prevent such common offenses as proliferation of schemes illicit trafficking in goods and smuggling, withdrawal from the shadow of trade in goods that imported from abroad. Emphasized on necessity to eliminate the problem of effectively coordination of the activities of customs control bodies, and also the problem of acceleration of control procedures, registration, control and others formalities at the border through the coordination of the Ukrainian legal framework with international standards. The analysis of the main problems of the previous customs is carried out control and suggested ways to solve them.

Argued areas for improving public administration by the customs control of Ukraine, which will help to detect offenses in research area more effectively, develop methods and approaches to their elimination and minimization and also to indemnify for damages incurred in the process of violating the law.
The standard of «beyond reasonable doubt» proof concept and its place in the proof standard system
Authors: Шаповал Анастасія
Published: June 2022

The criminal justice system in Ukraine is aimed at effective rights and interests’ protection of individuals, society and the state. Thereby, there is a necessity to introduce new and to improve existing elements, while acting due presumption of innocence as a fundamental principle that sets proof standards to be taken into account by the participants in the criminal proceedings, and also determines the obligation to bear the burden of proof.The ratification of the Universal Declaration of Human Rights, the European Convention for the Protection of Human Rights and Fundamental Freedoms, the International Covenant on Civil and Political Rights, and the Europeanization of Ukrainian law, in general, have made significant contributions to the implementation of proof standards in national practice. As a result, international human rights standards, including the right for a fair trial, have become an integral part of the scientific disputes.The article explores the standard «beyond a reasonable doubt» proof concept in criminal procedural law. During the research, the author has studied national legislation, domestic and foreign doctrinal resources. As a result, the proof standard has been examined as a comprehensive notion, and the criterion for achieving a certain level of belief following the standard "beyond a reasonable doubt" has been identified. The author commends the reader's attention to the correlation between the proof standard "beyond reasonable doubt" and other standards, the inner conviction of a judge or juro and the purpose of proof in criminal litigation.
Theoretical foundations of crisis management in the activities of public administration
Authors: Кровцова Тетяна , Лащенко Оксана , Кравцов Олег
Published: June 2022

It is known that the processes of reform of local self-government and territorial organization of government are accompanied by crises, risks and uncertainties, namely phenomena that negatively affect community life and require the use of anti-crisis approaches in the activities of public administration. Special relevance is the issue of improving the efficiency and competence of management of public administration, which cannot be done without the introduction of crisis management tools. The justification of this provision is chosen for the purpose of this article.The concepts of «crisis», «crisis management», «crisis management» are analyzed. The essence of anti-crisis management in the activity of public administration bodies is revealed. Peculiarities of using the concept of «crisis management» in the field of public administration are determined. The functions and principles of crisis management are outlined. The mechanism and technologies of anti-crisis activity in public administration are revealed. The breadth and evolution of views on the definition of «crisis management» are shown. Based on the analysis of modern publications, the stages of crisis management, the requirements for their diagnosis, the appropriate choice of priority actions are considered. These tools of crisis management. The conditions for successful implementation of anti-crisis management in the activities of public administration bodies have been clarified. The advantages of introduction of the newest methodical approaches of anti-crisis management, use of modern information and communication technologies and means of the analysis in anti-crisis management are analyzed. It is shown that the introduction of crisis management in the work of public authorities is a necessary condition for their effective operation.On the basе of the conducted research the conclusion on expediency of system and complex use of available tools of anti-crisis management considering a current situation, normative-legal maintenance and resource possibilities is made. The need for a full-fledged digital transformation based on the use of reengineering – a component of crisis management. Prospects for further research on this issue are outlined.
Використання маркетингового підходу в діяльності органів публічного управління медичною сферою
Authors: Кравцова Тетяна , Лащенко Оксана , Кравцов Олег
Published: June 2022

Реформування публічної сфери вимагає від органів публічного управління підвищення результативності управлінської діяльності, а отже пошуку нових інноваційних інструментів управління, які б задовольняли вимогам часу щодо якості, результативності та клієнтоорієнтованої діяльності. 

У статті розкрито сутність реалізації маркетингової концепції в публічному управлінні. Визначено ключові підходи щодо розуміння суті поняття «публічний маркетинг». Встановлено, що основною умовою формування маркетинговоорієнтованих послуг публічної сфери є забезпечення їх привабливості для потенційного споживача, фактично, сучасний споживач, його бажання визначають те, якими будуть управлінські послуги, що надаватимуть публічні інституції та органи публічної влади.

Ідентифіковано типи та основні інструменти комплексу маркетингу у публічному управлінні. Охарактеризовано маркетинг послуг, соціальний маркетинг, маркетинг політики та демаркетинг. Окрему увагу приділено територіальному маркетингу, як сучасному методу адміністративного менеджменту, новій концепції управління територією, в основі якої лежить нове розуміння ролі і функцій територіальних органів влади – як ефективного управління ресурсами даної території і надання населенню суспільних послуг. Розглянуто спільні ознаки публічних послуг, визначені механізми територіального маркетингу.

Визначено основні напрямки трансформації маркетингової діяльності органів публічного управління в умовах цифровізації. Описано форми та інструменти цифрового маркетингу, перспективні напрямки розробки його стратегій.

Показано, що застосування маркетингових технологій в охороні здоров’я спроможне сприяти оптимізації діяльності закладів охорони здоров’я та підвищенню якості медичних послуг. Проаналізовано окремі приклади використання інструментів публічного маркетингу Міністерством охорони здоров’я України, клієнтоорієнтований маркетинг сучасних закладів охорони здоров’я в умовах пандемія COVID-19.

Визначені особливості реалізації комплексу маркетингу у сфері публічного управління.
Oligarchic corruption: scenarios and technologies of external influence in Ukraine (theoretical and sociological aspect)
Authors: Гугнін Едуард
Published: June 2022

The article describes the relationship between oligarchic corruption and scenarios of external influence from the EU/NATO and Russia geopolitical alliances. It is concluded that the corruption of the oligarchs is one of the key conditions for effective external influence on Ukraine and the limitation of its cultural, political and economic sovereignty. At the same time, information campaigns by intellectual groups of opinion leaders are combined in media discourses with public communication of political actors and are converted into relevant decisions of the legislature and the executive.It is emphasized that the information confrontation takes place in line with two discourses: populist-pro-Russian and liberal-pro-Western. On the part of pro-Russian external actors, key arguments relate to the identification of the fight against corruption with the restriction of Ukraine's cultural and political sovereignty by the EU and NATO. For external influence through the oligarchy on the authorities and administration of Ukraine, the Russian Federation uses cultural and media trendsetting, criminal curation and political emissary.It is noted that the EU and NATO are counter-propaganda in the direction of continuous "pushing" programs to reform the political, economic, educational system with the leitmotif of combating corruption and the use of cultural and media trendsetting, political emissary and touring. For EU and US societies, political touring is one of the priority forms of external influence because of the significant benefits that external centers of power derive from the placement of groups of influence in state institutions. It was stated, first of all, that the surplus of non-ruling elites was moved to the periphery, which allowed to get rid of the corresponding inconveniences due to their possible transformation into political actors. Secondly, the strengthening of the cultural influence of society through the conquest by political tourists of the status of temporary role models in the field of public administration. Third, political touring is beneficial to the oligarchy because of the possibility of avoiding responsibility for corruption by transferring it to external centers of power. Fourth, political touring allows to maintain the image of Ukraine as a failed state, which is unable to recruit and select its own elites and create social elevators for leaders.