bluuebunny/crossref_metadata_2025 huggingface dataset:
La resolución pacífica y sostenible de conflictos familiares a través de la mediación.
Authors: Ayala Ayala Luis Ramiro , Jácome Merino Oscar Gonzalo , Mosquera Endara Mónica del Rocío
Published: December 2023

La investigación se centra en la mediación como una herramienta fundamental para abordar conflictos familiares, cubriéndose las bases conceptuales, ventajas y técnicas utilizadas, resaltando la creciente popularidad de la mediación, especialmente en situaciones que involucran a niños, debido a su enfoque en preservar las relaciones familiares y el bienestar emocional de todos los involucrados. Un aspecto fundamental de la mediación es que no impone soluciones, sino que promueve la comunicación y colaboración entre las partes en conflicto. El resultado final es un acuerdo que las partes crean conjuntamente, fomentando su cumplimiento, ya que surge de su compromiso y esfuerzo compartido.
La consideración de la ayuda a la mujer embarazada como carga familiar en el proceso de determinación de alimentos.
Authors: Gallegos Gallegos Simón Bolívar , Gallegos Salazar Cesar Stalin , Montecé Giler Salomón Alejandro , Hermoza Aguilar Fátima Elizabeth
Published: December 2023

Aunque el Código Civil protege los derechos del que está por nacer y la ley otorga derechos de alimentos al nacido, surgen conflictos con respecto al no nacido, que no se considera carga familiar, lo que crea inseguridad jurídica. El objetivo fue destacar la necesidad de abordar esta antinomia en la legislación ecuatoriana, tratando la ayuda a la mujer embarazada como carga familiar en el proceso de alimentos. Los resultados señalaron un vacío legal y una violación del derecho a la igualdad y no discriminación del progenitor al no considerar a la mujer embarazada como carga familiar en el cálculo de la pensión alimenticia.
Origen, conceptualización, tipología y propuesta teórica del federalismo fiscal.
Authors: Altamirano Santiago Mijael
Published: December 2023

En este escrito se expone principalmente las bases conceptuales y teóricas relacionadas con el federalismo y el federalismo fiscal; de tal forma, que sea posible comprender, primero, el origen del federalismo y la concepción del mismo, y segundo, se atiende en lo referente a la distribución de competencias y los modelos teóricos federales: Federalismo dual, Federalismo cooperativo, Federalismo competitivo y Federalismo asimétrico; asimismo, se alude a la propuesta teórica del federalismo fiscal y dentro de ésta los modelos centralizador y descentralizado, asociados a la discusión respecto a que ámbito de gobierno debe atender las funciones fiscales.
Propuesta de instalación de restaurante para control de la diabetes e hipertensión en Nuevo Laredo.
Authors: Díaz Roldán José Luis , Gómez Montoya Vanessa , Hernández Ancona César Eugenio
Published: December 2023

La presente investigación se enfoca en la administración y la mercadotecnia, especialmente en el análisis de mercado. Se elige el ámbito restaurantero, ya que propone ayudar a la población afectada por diabetes e hipertensión arterial en Nuevo Laredo, Tamaulipas. El objetivo principal es, evidenciar la falta de restaurantes para elegir platillos saludables a comensales y cumplir su régimen alimenticio. Con un enfoque cuantitativo, se interpretan y analizan resultados de encuestas realizadas a ciudadanos mayores de 18 años, así como a nutriólogos. De acuerdo con al análisis realizado, los encuestados manifestaron excelentes opiniones sobre la instalación de un restaurante con menú a cuidados nutricionales; es un segmento nuevo, que propone distinguirse otras comidas como mariscos, alimentos rápidos, parrilladas, entre otros.
Beneficios y usos de los frutos andinos motilón (Hieronyma macrocarpa) y capulí (Prunus serotina) en la comunidad de San Luis, Atahualpa, Chibuleo - Tungurahua.
Authors: Jaramillo Burgos Manuel Fernando , Poveda Morales Tannia Cristina , Ortiz Andino Lia Cristina , Richard Adrián Richard Adrián
Published: December 2023

La innovación en la gastronomía es crucial para destacar en el ámbito culinario global, y en ese contexto, se llevó a cabo una encuesta para recopilar datos sobre la utilización de estos alimentos en recetas culinarias y se creó un recetario específico para fomentar su incorporación en la cocina. Los resultados revelaron una percepción positiva en cuanto al uso de estos frutos, con la mayoría de los encuestados estando de acuerdo en que su inclusión en la cocina ampliaría las posibilidades culinarias y enriquecería los sabores, por ello se ha logrado una mayor apreciación de estos ingredientes, lo que promueve su versatilidad y su incorporación en la cocina de manera más creativa y diversa.
La legitimidad de la criptomoneda Bitcoin y las consecuencias legales en situaciones de fraude.
Authors: Mosquera Endara Mónica del Rocío , Banda Paredes Cristian Patricio , Calderón Velásquez María José , Jácome Merino Oscar Gonzalo
Published: December 2023

El Bitcoin, una criptomoneda independiente del sistema financiero tradicional, tiene un estatus legal y regulación variables según el país. En algunos lugares, es considerada moneda legal y se usa en transacciones, mientras que en otros está prohibida. Su valor en los mercados es altamente volátil. Aspectos legales como la protección de usuarios, prevención de actividades ilícitas y tributación son relevantes, junto con la necesidad de regulaciones sólidas. El propósito de la investigación es examinar en detalle el uso del bitcoin, incluyendo su origen y definiciones, su influencia global y su legalidad, así como las acciones a tomar en casos de estafa, teniendo en cuenta que su compra y venta son permitidas, aunque no siempre para bienes y servicios.
ATIK OLİVİN TOZU İKAMESİ İLE ÜRETİLEN SÜRDÜRÜLEBİLİR ÇİMENTONUN EĞİLME DAYANIMININ OPTİMİZASYONU: YANIT YÜZEYİ METODOLOJİSİNİN BİR UYGULAMASI
Authors: ÖZKAN Şükrü
Published: December 2023

Çimentoda atık olivin tozu (AOT) ikamesi, kabul edilebilir mekanik özelliklere sahip çimento üretiminin yanı sıra maden atıklarının geri dönüşümü ve çevre sorunlarının azaltılması için de uygun bir alternatiftir. Bu araştırma, AOT ile üretilen çimento karışımlarının hem atık geri dönüşümü hem de yüksek eğilme dayanımı açısından optimum karışım oranını belirlemeyi amaçlamaktadır. Bu amaçla, çimento ve AOT içeriği ile hidratasyon süresi olmak üzere üç bağımsız değişkenin, çimentoların eğilme dayanımı tepki değişkeni üzerindeki etkisi deneysel olarak incelenmiştir. Bağımsız ve yanıt değişkenleri ilişkisinin modellenmesi ve optimizasyon senaryosunun çok amaçlı optimizasyonu için yanıt yüzeyi metodolojisi (YYM) ve arzu edilirlik fonksiyonu yönteminin bir kombinasyonu uygulanmıştır. Sonuçlar, atık geri dönüşümü ve çimento üretimi açısından en iyi optimizasyon senaryosunun, AOT ve eğilme dayanımını en üst düzeye çıkarmak ve çimento miktarını en aza indirmek olduğunu göstermiştir. Bu senaryo için çimento içeriği ve hidratasyon süresinin optimum değerleri sırasıyla 410 kg/m3 ve 90 gün ve bu durumda çimento eğilme dayanımı ise yaklaşık 11.23 MPa olarak tespit edilmiştir. Sürdürülebilirliğe doğru bir adım olarak bu çalışmanın sonuçları, araştırmacılara hem atık geri dönüşümü hem de çimento üretimi açısından en verimli koşulu bulma konusunda yeni bilgiler sunmaktadır.
Fuzzy Power Converter for Traffic Control System
Authors: Sambhaji Damame Shradha , Awati J. S. , Kumbhar M. S.
Published: December 2023

Although fuzzy logic does not always replace conventional control methods, it can be built upon the experience of experts and combined with them. In fact, in many cases, fuzzy control systems make the implementation process easier. In many cities, traffic congestion is a result of an increase in vehicles and a lack of available roads. This has an impact on productivity, efficiency, and energy losses. The traffic signal controller operation methodology at road intersections is one of the main causes of this congestion. Based on fuzzy logic theory, we proposed a fuzzy traffic control system in this paper. By regulating the length of the green phase interval, our suggested system can effectively manage the traffic at the intersection.
Fraccionamiento bioguiado antimicrobiano de metabolitos secundarios de Jungia axillaris (Lag. ex DC.) Spreng. Asterácea de las zonas altoandinas de Arequipa
Authors: Montiel Rossana Georgina Juárez , Macedo María Isabel Hancco , Gonzales Rolando Moisés Perca
Published: December 2023

En la presente investigación se han empleado las hojas y tallos de la especie vegetal Jungia axillaris (Lag. ex DC.) Spreng, recolectada del distrito de Alca, provincia Altoandina de Cotahuasi en el departamento de Arequipa, para su estudio químico bioguiado antimicrobiano, en la identificación de fracciones bioactivas y la caracterización de los metabolitos secundarios presentes. Se realizó dos extracciones con etanol absoluto y diclorometano:etanol (1:1)  a temperatura ambiente por 72 horas, los extractos crudos se concentraron al vacío en un rotaevaporador, se realizó el análisis fitoquímico y se fraccionaron por cromatografía en columna con solventes diclorometano, éter de petróleo, etanol y etanol:agua, con fase estacionaria silicagel 60, como control del fraccionamiento se hizo cromatografía de capa fina (TLC) siendo la fase estacionaria silicagel 60 F254  y la fase móvil   hexano: acetato de etilo C6H14: AcOEt  (60:40),  en cada etapa de fraccionamiento se probó la bioactividad antimicrobiana frente a Staphylococcus aureus ATCC 25923. Del análisis fitoquímico se determinó la presencia de flavonoides, alcaloides, carbohidratos, taninos, compuestos aromáticos y compuestos terpenoides. El extracto etanolico crudo presenta una actividad muy sensible frente a la cepa bacteriana de Staphylococcus aureus ATCC 25923, el extracto crudo de diclorometano: etanol (1:1) frente a esta cepa presento una sensibilidad nula. El fraccionamiento llevo a fracciones antimicrobianas que presentan en común compuestos de coeficiente de retención (Rf) 0,63 y 0,68 que por los ensayos frente a revelantes químicos dan positivo para alcaloides, compuestos terpénicos y compuestos con agrupamiento lactónico. Asimismo, se determinó que el extracto crudo etanolico presenta una Concentración Mínima Inhibitoria (CMI) de 12,5 mg/mL y una Concentración Mínima Bactericida (CMB) de 12,5 mg/mL.
Modelo de Programa Institucional de Tutoría del Instituto Tecnológico Superior de Huetamo enfocado al cumplimiento de estándares de los organismos acreditadores de programas educativos en ingeniería
Authors: Dueñas Carlos Reyes , Angulo Ricardo Ávila
Published: December 2023

El presente modelo del Programa Institucional de Tutoría refiere a una propuesta del esquema de tutorías en el Instituto Tecnológico Superior de Huetamo, de manera que este sea bien organizado y estructurado para fortalecer el seguimiento de los indicadores de impacto en la matrícula, como pueden ser deserción, reprobación y aprovechamiento. Bajo esta organización se plantean 4 fases en la trayectoria estudiantil en el programa educativo, las cuales a su vez están estructuradas por etapas para procurar asegurar el seguimiento de los estudiantes, y generar estrategias que contribuyan a su retención, regulación académica, o a potenciar habilidades según sea la característica del grupo o generación. Las fases del modelo son integración, consolidación, desarrollo y transcendencia, mientras que las etapas son recepción, inscripción-reinscripción, caracterización, plan de acción tutorial y, reportes y seguimiento. La recepción ordena los tiempos y actividades de preparación y diagnóstico, mientras que la caracterización interpreta los datos del diagnóstico para obtener los perfiles del grupo generacional, de manera que se identifiquen amenazas o debilidades, así como habilidades para potenciar, para posteriormente planificar las acciones en un plan y poder dar seguimiento a ella y sus resultados. El modelo también toma en consideración las canalizaciones, capacitación y evaluación de los actores, y del mismo programa. Las canalizaciones son un mecanismo para la prevención, remediación, y potencialización de casos individuales. La capacitación, y evaluación de los actores y programa, son parte de la mejora continua para que el modelo promueva su actualización y adaptación a la naturaleza de las generaciones.
Implementation of Technology Enhanced Formative Assessments in 21st Century Education
Authors: Krishnan Jeevanithya
Published: December 2023

Teaching methods in the 21st century are more inclined to be more creative and innovative in engaging students in the digital era. Technology tools have become pivotal in 21st-century education, where students prefer flexible learning. 21st-century learning has also become more inclusive, where students become active learners. 21st-century learning has also taken a paradigm shift in analyzing student performance. Student progress is monitored by their continuous performance in the classroom in the form of feedback-based formative assessments instead of limiting them to graded summative assessments. This paper focuses on lecturers’ views on 21st-century classrooms and their challenges in implementing 21st-century learning methods. The role of technology-assisted formative assessments has also been investigated through qualitative research conducted among selected lecturers from two departments in a private institution. Research findings proved that lecturers are much more inclined towards 21st-century learning as students and lecturers like more interactive and formative assessments, as they promote continuous learning. However, using technology tools has mixed among lecturers due to its constraints in certain boundaries. It is also found that implementing 21st-century learning in the classroom contributes to challenges for the lecturers regarding technology adaptation, time constraints, and student motivation.
Storybook as a Preventive Measure Against the "Sexual Harassment" of Children in the Elementary School
Authors: Putro Hendro Yulius Suryo , Jamain Ririanti Rachmayanie , Hairunisa Hairunisa , Ariliani Tiara
Published: December 2023

The three great sins of education, bullying, sexual violence and intolerance - still occur in schools. Cases of sexual harassment were found to occur in primary schools. Guidance and counseling are considered the most important parts in this case, where class teachers implement counseling services in primary schools. Sex education can be provided through interesting media. This research aims to produce a learning medium: a storybook about sexual harassment. This research method uses the ASSURE research and development model (Analyze learners, State objectives, select methods, media and materials, utilize media and materials, require learner participation, Evaluate and revise). The research was conducted on students of Grade VI of SDN Sungai Miai 7 Banjarmasin. Material experts, media experts and students as users validated the storybook media. The results showed that the storybook materials met the criteria of being very feasible regarding media and materials and that students' understanding of sexual harassment increased after reading the storybook.
Academic Supervision Practices Integrated into the School Supervisor Support Programs
Authors: Victorynie Irnie , Othman Azam Bin
Published: December 2023

Academic supervision stands out as a commendable initiative designed to aid and bolster teachers in executing their responsibilities within the school setting. Moreover, numerous challenges and hindrances faced by educators are tackled through the implementation of academic supervision activities. This research aims to explore teachers' experiences undergoing academic supervision and the supervisors' support to overcome teacher problems and improve their performance. Researchers used qualitative research methods with an exploratory case study approach. Data was obtained from semi-structured interviews. The informants were four teachers at two integrated Islamic elementary schools in Bekasi, Indonesia, who were selected based on their extensive experience in carrying out school academic supervision. The resulting data was analyzed thematically using Atlas.ti software. The findings reveal that academic supervision is incredibly beneficial for teachers. It does not only assess teacher performance but also helps teachers solve problems to improve teacher performance. Teachers also received many support programs to improve the quality of learning in their schools.
Risk of dementia in the elderly with non-alcoholic fatty liver disease: A nested case-control study in the Republic of Korea
Authors: Yoo Sung Hwan , Park Ju-Young , Lee Hye Sun , Lee Hyun Woong , Lee Jung Il
Published: December 2023

Introduction: Non-alcoholic fatty liver disease (NAFLD) is known to be associated with metabolic syndrome of which diabetes is an important component. Although diabetes is a known risk factor for dementia, studies on the association between NAFLD and dementia still produce conflicting results. This study aimed to determine whether NAFLD would be a risk factor for the development of dementia in an elderly population.

Method: This study included 107,369 subjects aged ≥60 years in the Korean National Health Insurance Service-Senior cohort, entered in 2009 and followed up until 2015. NAFLD was diagnosed by calculating fatty liver index (FLI). Subjects were screened for dementia at baseline using a Korean Dementia Screening Questionnaire, and dementia was diagnosed using ICD-10 codes. Controls were randomly selected at a ratio of 1:5 from individuals who were at risk of becoming the case subjects at the time of selection.

Results: From 107,369 subjects, 65,690 stroke- and dementia-free subjects without chronic hepatitis B or C or excessive alcohol drinking were selected for evaluation. Having NAFLD, determined by FLI, was associated with increased risk of dementia development (adjusted odds ratio [AOR] 1.493; 95% confidence interval [CI] 1.214–1.836). The increased risk of dementia in NAFLD subjects was independent of type 2 diabetes (AOR 1.421; 95% CI 1.013–1.994, in subjects with diabetes: AOR 1.540; 95% CI 1.179–2.010, in subjects without diabetes).

Conclusion: In this population-based nested case-control study, having NAFLD increased the risk of dementia in elderly individuals, independent of accompanying diabetes.
Political Decentralization and the Emergence of the Local State Capture: Lessons from Bengkulu, Indonesia
Authors:   Department of Sociology, Faculty of Social and Political Sciences, University of Bengkulu Jalan Raya Kandang Limun – Bengkulu – INDONESIA 38371.A, Suminar Panji
Published: December 2023

The local state capture phenomenon becomes very interesting if it is associated with the macro state capture framework that has begun to develop in the last two decades. A more multifaceted political approach is needed because state erosion is a political problem, not just an economic one. By referring to the political ethnographic tradition, this study describes how the complexity of relations between local economic, political, and ruling elites leads to the emergence of local state capture and the scope of its power. This study concludes that the weathering or weakening of formal government functions is not the source of the emergence of the local capture phenomenon. The growth of local state capture is more owing to the one-of-a-kind interaction between local political and economic actors and the ruling elite since the direct election of regional leaders takes place. This elite collaboration results from the emergence of a local oligarchic pole controlling local resources. The initiation of relations between the economic and political elite and the ruling elite is not only because of economic spheres but because they want to be part of the rulers' closest political circle of power.
High Impedance Fault Detection and Location in the Nigerian 330 kV Transmission Network Using Adaptive Neuro-Fuzzy Inference System
Authors:   Department of Electrical and Electronic Engineering, Akwa Ibom State University, Ikot Akpaden, Nigeria, Oduleye Ayokanmi Emmanuel , Nkan Imo Edwin ,   Department of Electrical and Electronic Engineering, Akwa Ibom State University, Ikot Akpaden, Nigeria, Okpo Ekom Enefiok ,   Department of Electrical and Electronic Engineering, Akwa Ibom State University, Ikot Akpaden, Nigeria
Published: December 2023

Fundamentally, the occurrence of high impedance fault (HIF) can be established when an energy filled conductor contacts a semiconductor. The occurrence of HIF can be described to be subtle and disastrous as it results to low current signal and a signal voltage arc if undetected and without implementation of protective measures, leads to the damage of the power system equipment and in many cases fire outbreak. In this study, the occurrence of HIF on the south-south region of Nigerian 330kV transmission line was studied with the data utilized obtained from the Nigerian control center (NCC) Osogbo. The data obtained was modeled in simulink and the outcome at normal condition was obtained. The transmission line distance was split into 4 points with the current signal at each point generated in simulink and exported to the Matlab file. The data in Matlab file was split to train, test and validate at 70%, 15% and 15% respectively. The data analysis performed was sent to Adaptive Neuro-fuzzy inference system (ANFIS) with the current signal at normal condition and at 3-phase HIF was used as input data while the split distance was implemented as the target data to the model. The effectiveness of the model in detecting and locating HIF was obtained and analyzed in a comparative plot of the location distance. From the results presented, the highest error deviation for fault location with ANFIS was 10%. Hence, it was concluded that ANFIS model had a satisfactory outcome in HIF detection and as such should be utilized for the HIF detection and location.
A Quick Guide for Topical Treatment for Psoriasis
Authors:   IMSS Hospital General de Zona no. 5, Nogales, Sonora., Contreras Diego Mendoza , Corrales Bay Fernanda ,   IMSS Hospital General de Zona no. 5, Nogales, Sonora., Martinez Emily Hoyos ,   IMSS Hospital General de Zona no. 5, Nogales, Sonora.
Published: December 2023

Psoriasis, a chronic inflammatory skin disorder, presents a therapeutic challenge due to its diverse manifestations and impact on patients' lives. This review delves into the intricacies of topical agents used in managing psoriasis, encompassing corticosteroids, vitamin D analogs, retinoids, calcineurin inhibitors, and unconventional treatments like coal tar and salicylic acid. Each agent's potency, application, and considerations for different age groups are discussed, providing clinicians with a comprehensive guide for treatment selection. The multifaceted nature of psoriasis requires tailored approaches, and understanding the nuances of these topical therapies is crucial for optimizing outcomes. Ongoing research promises further advancements in psoriasis management, holding potential for more personalized and effective interventions.
PENAMBATAN DAN SIMULASI DINAMIKA MOLEKULER SENYAWA BIOAKTIF TANAMAN BAWANG DAYAK (Eleutherine Sp.) SEBAGAI INHIBITOR KAPSID VIRUS HEPATITIS B
Authors:   Universitas Pakuan, Sari Bina Lohita , Suhendar Usep ,   Universitas Pakuan, Hamdani Ridho ,   Universitas Pakuan
Published: December 2023

Hepatitis B merupakan penyakit infeksi hati yang disebabkan oleh virus hepatitis B. Kapsid pada virus hepatitis B adalah lapisan yang berfungsi untuk melindungi RNA dan DNA virus dari kerusakan. Tanaman yang diketahui memiliki aktivitas sebagai antivirus adalah bawang dayak. Penelitian ini bertujuan untuk menghasilkan senyawa hit hasil penambatan dan simulasi dinamika molekuler. Target Makromolekul yang digunakan adalah PDB ID : 5GMZ dan 33 senyawa dari tanaman bawang dayak. Penambatan molekuler menggunakan AutoDock Vina dan validasinya dengan menentukan kurva ROC dan perhitungan nilai AUC, menentukan RMSD secara redocking. Seleksi dengan aturan Lipinski Rule of 5 untuk menghasilkan senyawa yang dapat digunakan secara oral. Simulasi dinamika molekuler menggunakan program Gromacs 5.1.5 dan g_mmpbsa. Hasil seleksi Lipinski Rule of 5 menghasilkan 28 senyawa. Hasil penambatan menunjukkan senyawa Eleuthosida A memiliki nilai afinitas lebih negatif (-7,5 kkal/mol) dibandingkan pembanding 6XU dan isothiafludine (-7,4 dan -6,1 kkal/mol). Simulasi dinamika selama 20ns menunjukkan nilai RMSD dan RMSF Eleuthosida A dalam keadaan stabil dengan okupansi ikatan hidrogen sebesar 18,81% pada asam amino Asp29. Energi bebas MM-PBSA pada senyawa Eleuthosida A merupakan senyawa dengan paling negatif yaitu -133,430 kkal/mol. Berdasarkan hasil tersebut, Eleuthosida A dapat dijadikan kandidat inhibitor kapsid virus hepatitis B
KANDUNGAN FITOKIMIA DAN METODE UJI EKSTRAK GENDARUSSA (Justicia gendarussa Burm. F) SEBAGAI ANTI-HIV : ARTIKEL REVIEW
Authors:   Institut Pertanian Bogor, Nurcholis Waras , Aryani Hanifah ,   Institut Pertanian Bogor, Hasan Firmanul ,   Institut Pertanian Bogor
Published: December 2023

Pencarian pengobatan alternatif terbarukan untuk HIV/AIDS terus berkembang. Salah satu pendekatan untuk pengembangan obat anti-HIV dilakukan melalui penelitian menggunakan obat herbal tradisional. Justicia gendarussa Burm. F terkenal memiliki banyak manfaat di bidang medis, seperti antibakteri, antiinflamasi, antioksidan, analgesik, antikanker, antidiabetes, dan antiviral. Sebagai antiviral, ekstrak J. gendarussa teruji aktivitasnya secara in silico dan in vitro sebagai anti-HIV. Review ini bertujuan untuk memberikan informasi terkait potensi ekstrak J. gendarussa sebagai pengobatan alternatif HIV/AIDS terbarukan serta metode yang dapat digunakan untuk mengevaluasi aktivitasnya sebagai anti-HIV. Senyawa-senyawa pada J. gendarussa yang teruji aktivitasnya sebagai anti-HIV adalah justiprocumin A dan B, patentiflorin A, dan gendarusin A. Senyawa-senyawa tersebut memiliki aktivitas anti-HIV lebih baik dibandingkan obat HIV zidovudine (AZT) dan nevirapine serta dapat menghambat isolat HIV yang resisten terhadap obat NRTI (nucleoside reverse transcriptase inhibitor) dan NNRTI (non-nucleoside reverse transcriptase inhibitor)
Impact of Supply Risk Sharing on Supply Chains: Multiplicative vs. Additive Risks
Authors: Bae Junhyun , Choi Ji-Hung (Ryan)
Published: December 2023

Abstract
We consider a supply chain in which a retailer orders from a manufacturer(s) who face(s) a stochastic supply risk (random yield) under single or dual-sourcing cases. In specific, we look into this problem in two different yield risks: multiplicative and additive. One might intuit that if the retailer shares a manufacturer’s random yield risk with the manufacturer, the manufacturer will be better off. Interestingly, we confirm that this intuition is only valid in the additive yield risk but not necessarily in the multiplicative yield risk. Moreover, under dual sourcing, both manufacturers fiercely compete on their prices (i.e., Bertrand-like competition) to become the sole source in the additive yield risk, but the manufacturers do not compete as much in the multiplicative yield risk. Lastly, this paper shows that the supply chain inefficiency may decrease (increase) as risk-sharing increases in the additive risk model under dual sourcing (single sourcing) while it does not changeinthemultiplicativeriskmodel.

Key words: supply risk, random yield, dual sourcing, game theory
JEL Classification: L11, M11, M21
Bulgária?!
Authors: Cardoso Cezário Vanessa
Published: December 2023

Neste trabalho, tenho por objetivo contextualizar, apresentar e discutir a minha experiência com o ensino de português na Bulgária. Por meio de metodologia qualitativa, apoiada em documentos e referências bibliográficas, discutirei, ainda, questões relacionadas à cooperação acadêmica para internacionalização entre países do Eixo Sul. Entendo que o principal resultado deste trabalho, além da reflexão a respeito de uma experiência individual, é colaborar com uma temática que, devido à novidade de sua configuração, dispõe de poucos dados e análises.
Conturbadas Memórias: narrativas da nação brava
Authors: Miguel Marcelo  Calderari
Published: December 2023

Os três poemas apresentam diferentes momentos históricos e eventos importantes na história do Brasil. Eles retratam momentos de agitação política, lutas pela liberdade e confrontos regionais.

No primeiro poema, intitulado "I Constituinte e Chalaça, Noite da Agonia", é destacada a tumultuada sessão da Assembleia Constituinte brasileira, onde deputados debatiam a elaboração de uma constituição. O conflito entre Antônio Carlos de Andrada e o imperador D. Pedro I é abordado, mostrando a tensão e o embate de ideias na busca pela liberdade. A aprovação da proposta constitucional traz consigo a agonia, pois o ministro do Império impõe restrições à imprensa e demissões, colocando a liberdade em perigo.

O segundo poema, intitulado "II Onde repousam Heróis, épica é a batalha", rememora a Batalha do Jenipapo, um marco da luta pela independência do Brasil. O poema destaca a importância do cemitério do Batalhão e do monumento do Jenipapo como símbolos venerados e honrados da história do país. A bravura e coragem dos combatentes são exaltadas, mesmo diante da derrota, e seu legado serve como exemplo inspirador para as gerações futuras.

O terceiro poema, intitulado "III Revoltas no Pampa, Maragatos e Chimangos", retrata a Revolução de 1923 no Rio Grande do Sul. O conflito entre os Maragatos, defensores de Assis Brasil, e os Chimangos, apoiadores de Borges de Medeiros, é destacado. A crise na pecuária e a fraude na reeleição são apontadas como desencadeantes da revolta. O poema ressalta a violência e a censura à imprensa durante o período, além de enfatizar a união dos revolucionários em colunas e o impacto do conflito na história do Rio Grande do Sul.

Em suma, os três poemas despertam reflexões sobre a importância desses eventos e seu legado na construção entre memória, identidade, patrimônio e o destino do país e da brava gente brasileira.
robôs devem substituir os professores? Uma abordagem de Neil Selwyn
Authors: Antunes Pereira Carla
Published: December 2023

“Should robots replace teachers?: AI and the future of education” é o  livro publicado em 2019 do autor Neil Selwyn. A obra em análise surge com objetivo de discutir o uso da inteligência artificial na educação e como essa proposta ameaça ou não a permanência de professor humano na sala de aula. A partir da questão principal que norteia a obra “Os robôs deveriam substituir os professores?”, o autor levanta outros apontamentos que envolvem problemáticas de origens sociais, políticas e ideológicas e nos convida a reflexão para discutirmos sobre qual será o futuro da tecnologia, em especial a inteligência artificial, na educação. Dividido em cinco capítulos, a obra contextualiza uma série de questionamentos ao longo de todo texto que nos remete a pensar sempre de forma crítica em relação ao tema.
A dança nas manifestações culturais em municípios do Vale do São Francisco:
Authors: Conselho Ana Carla Pereira Martins , Lima Artur Gomes Dias , Santos Carlos Alberto Batista
Published: December 2023

Este estudo apresenta os resultados da pesquisa que investigou a presença de grupos de dança em quatro municípios localizados na região do Vale do São Francisco, com o objetivo central de registrar informações sobre os conhecimentos e práticas locais relacionados às manifestações culturais características de cada localidade. A seleção dos informantes foi realizada através da técnica da bola de neve, usando como instrumento de coleta de dados entrevistas. Para a análise, os dados históricos foram analisados de forma qualitativa, utilizando o software Atlas.ti. Essa abordagem permitiu a codificação, e a análise de conteúdo, das diversas competências individuais dos participantes dos grupos envolvidos. Por meio desta análise, fica claro que a preservação e promoção das manifestações culturais desses grupos são essenciais, não só para proteger o patrimônio cultural, mas, estas também contribuem para o avanço social, cultural e ambiental das comunidades envolvidos.
Biological nitrogen fixation in sorghum: a basis for reduction of synthetic nitrogen dependence
Authors:   , Paula Thiago de Almeida
Published: December 2023

The increasing population and its demands require intensifying the current agricultural model to boost productivity. Chemical fertilizers, especially nitrogen fertilizers, play a crucial role in improving agriculture in Brazil, making it a major importer. However, excessive use of chemical fertilizers raises production costs, causes environmental damage, and impacts soil microbial ecology and dynamics, which could pose long-term problems as plant-microbe interactions are considered a solution for sustainable agriculture. Hence, the agricultural model must be reassessed to reduce the demand for synthetic fertilizers and increase the use of microorganisms that enhance production sustainability. The study aimed to examine the impact of nitrogen fertilization on the diazotrophic community associated with sorghum plants and evaluate the feasibility of using pre-selected bacteria in combination with different levels of nitrogen fertilization to improve sorghum productivity and reduce chemical N fertilization dependence. The study consisted of several experiments, including: isolation of N-fixing and plant growth-promoting bacteria, selection of bacteria with biotechnological potential, evaluation of the impact of nitrogen fertilization on diazotrophic microbiota during sorghum sowing, testing the agronomic efficiency of pre-selected bacteria under greenhouse conditions, and evaluating the agronomic efficiency of pre-selected microorganisms in field conditions. The results of the study showed that different levels of nitrogen fertilization affect the composition of the diazotrophic community associated with various parts of the sorghum plant, reducing its richness, uniformity, and diversity. Inoculation with selected plant-growth promoting bacteria (Rhizobium sp. and Sphingomonas sp.) in combination with reduced levels of nitrogen fertilization significantly improved stem diameter, shoot and total dry mass, and nitrogen content of the shoot under greenhouse conditions. In field conditions, inoculation with a mixture of all tested bacteria (Rhizobium sp. and Sphingomonas sp.) showed the potential to increase forage sorghum productivity and reduce nitrogen fertilization by 25-50 %. These results indicate the potential of using these microorganisms as a biotechnological tool for sustainable agriculture. The study concluded that nitrogen fertilization impacts the diazotrophic community of sorghum plants and that the N-fixing and growth-promoting bacteria selected from the sorghum rhizosphere as seed inoculants have the potential to reduce the need for synthetic nitrogen fertilizers in sorghum production. Further research is needed to determine the optimal balance between inoculants and fertilization rates for an integrated fertilization model. Keywords: Sorghum. Biological Nitrogen Fixation. Rhizobium. Sphingomonas.
Тезисы Конгресса ревматологов, посвященного 100-летию со дня рождения академика В.А. Насоновой
Authors: Editorial Article
Published: December 2023

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Health Information in Social Media: An Evaluation of YouTube Videos
Authors:   Assistant Professor, Department of Multimedia, School of Design, Vellore Institute of Technology, Vellore, Tamilnadu, India, Masilamani Vaageessan , Arulchelvan S ,   Associate Professor, Department of Media Sciences, Anna University, Chennai, Tamilnadu, India
Published: December 2023

New media hold the rapid dominance over the health information. People acquire the health information in different social media which includes YouTube, popular video sharing site. A systematic protocol was used to locate the 200 videos on YouTube in 20 different health topics. Blind coding was followed with two independent coders in the topics of authorship, channel types, information in video, elements shown in video, and the authenticity of the health information was analyzed using the eight standard HONCode principles. Profit organization took the major role of presenting the 109 (54.5%) health information videos on YouTube. Majority of the health information video produced by the profit organization lay in the field of medium (3-5) HONCode result, even the consumer authorship was the highly represented in the profit organization. The authenticated sources like educational institutions, Government organizations, Medical center, and Non-Profit organization do produces the highly authenticated (6-8 HONCode) health information; but their volume of producing the videos is quite low
The burden of cardiovascular disease in South Asia: the need for effective treatment
Authors: Immad Muhammad Usman
Published: December 2023

Dear Ma'am,
Cardiovascular disease (CVD) is rapidly becoming the leading cause of death worldwide (1). According to global health projections, it will remain the number one cause of death in 2030. The Asian region has been shown to have a higher cardiovascular disease burden than Western countries, and most of this burden is borne by economically disadvantaged people mainly located in South Asian regions such as Pakistan. (1). A large-scale survey conducted in 53 cities in Punjab, Pakistan, found that 17.5% of the population suffered from cardiovascular disease (2).
Mechanical thrombectomy is a minimally-invasive procedure where a specialized interventional radiologist utilizes specific equipment to remove a blood clot from an artery in a patient's body. This procedure treats arterial blockages caused by blood clots such as Deep Vein Thrombosis (DVT), Ischemic Stroke, etc (3).
MegaVac, a part of mechanical thrombectomy, is the newest technique for the removal of blood clots from arteries. It is an invasive procedure that ensures the complete removal of clots from the occluded artery. The biggest advantage of this technique over typical clot removal is that it prevents embolus formation, which can occlude smaller arteries.
The MegaVac Thrombectomy System is an intravascular mechanical thrombectomy and aspiration device with a single use that includes a thrombowire with an embolectomy component. A distal silicone-coated nitinol braid used in the SafeSealTM technology of the MegaVac Catheter swells to momentarily obstruct antegrade blood flow. The braid is expanded by the inner and outer coaxial shafts of the catheter body, briefly occluding the channel and enabling aspiration.  SafeSeal funnel is activated by the assembly of the proximal handle. A nitinol embolectomy component that is part of the thrombowire can be used to draw material in the direction of the MegaVac catheter when it is inflated by the proximal actuation handle (4).
Thrombectomy is a common and effective procedure for clot removal but in Pakistan thrombectomy is not as common compared to developed countries, primarily due to two reasons. First, Mechanical thrombectomy is exclusively available in four hospitals nationwide, with only one public hospital in Lahore providing this procedure (5). Second, it is an expensive procedure that ranges from 1700$ to 5000$ depending on the severity of the patient and the complexity of the procedure. Health Departments of Pakistan should provide this facility in more public hospitals so it becomes accessible to more people.
The endocrinology of the urinary bladder
Authors: Saptarshi Bhattacharya  , Arbinder Kumar Singal  , Sanjay Kalra
Published: December 2023

The urinary bladder primarily functions as a reservoir for urine. Apparently, it serves only a mechanical and passive role in the urinary tract, but closer scrutiny reveals that it has several meaningful endocrine interactions. This vital organ has an intricate plexus of neurons that release neurohormones concerned with the functioning of the bladder. Endocrine disorders, most notably diabetes, can cause a broad spectrum of bladder dysfunction. The current review explores the bladder as a source of neurotransmitters, a target for organ damage due to uncontrolled endocrinopathy, a beneficiary of hormonal therapy, and a tool to improve endocrine health.
Keywords: Urinary bladder, diabetes, lower urinary tract symptoms, overactive bladder, urinary obstruction
Emotional fluidity in chronic care
Authors: Sanjay Kalra  , Suneet Verma  , Nitin Kapoor
Published: December 2023

In this exploratory opinion piece, we define emotional fluidity as a state of changing emotions which influence choice of, attitudes and behaviour towards, and response to, chronic health care and therapy. This manifests clinically as changing opinions regarding suitability of modern health care, and as or varying, responses to suggestions and interventions from the health care team. Diabetes distress is an extreme example of emotional fluidity. Emotional fluidity also encompasses the variability of the health care professional’s response to emotional and medical needs of persons seeking care. This can be inter-individual or intra-individual, and can be influenced by compassion fatigue. Health care professionals should be aware of emotional fluidity, and should be able to address its negative impact, as well as amplify its positive influence.
Keywords: Patient centred care, Person centred care, Psychosocial aspects.
Rapidly growing massive abdominal sarcomatoid carcinoma on F18-FDG PET-CT scan
Authors: Tanzil Sajid  , Aamna Hassan
Published: December 2023

Sarcomatoid carcinoma is a rare type of tumour and most commonly arises in the lungs. However, rarely can it also be found in the abdomen. Sarcomatoid tumours are aggressive with large tumoural volume showing cancerous epithelial cells mixed with sarcomatous (nerve, muscle, fat etc.) features on histopathology. Most of the carcinosarcomas arise in the background of pleomorphic adenoma, originating from a myoepithelial precursor. These tumours are resistant to treatment and rapidly metastasize. We present a unique case of hepatocellular sarcomatoid sarcoma, evaluated through F18-FDG PET/CT.
Keywords: Sarcomatoid sarcoma, 18F FDG PET-CT, massive abdominal mass.
International Congress on Health in Arbaeen; to strengthen inter-departmental coordination and synergy to reduce the obstacles in providing health services to the pilgrims
Authors: Mulazim Hussain Bukhari  , Muhammad Ali Kumail
Published: December 2023

The 3rd international congress on Arbaeen in health was a significant event held from 2nd to 4th August, 2023 in Tehran, Iran. It brought together experts and scholars from nine countries to discuss and exchange knowledge on health-related issues during the Arbaeen pilgrimage. This congress provided a platform to explore innovative approaches, research findings, and best practices in promoting health and well-being among Arbaeen pilgrims. It also facilitated networking and collaboration among healthcare professionals, researchers, and policymakers, leading to the development of effective strategies for ensuring the health and safety of the millions of pilgrims participating in the Arbaeen pilgrimage. This congress will play a crucial role in advancing healthcare practices and enhancing the overall pilgrimage experience. The Arbaeen pilgrimage, which is one of the largest religious gatherings in the world, takes place 40 days after Ashura, the martyrdom anniversary of Imam Hussain (AS), the third Imam of Shia Muslims, and the grandson of Prophet Muhammad (PBUH). Each year, a huge crowd of people flock to Karbala, where the holy shrine of Imam Hussein (AS) is located, to perform mourning rituals. This year Arbaeen was on September 6,2023.
Keywords: Arbaeen, Congress, Health, Hilal e Ahmar, Karbala, Imam e Hussain, Pilgrim
Gut microbiota and myeloproliferative neoplams
Authors: Adeniyi Abraham Adesola  , Yongfeng Chen  , Mihnea Alexandru Gaman
Published: December 2023

The human gut microbiota refers to the collective assembly of microorganisms inhabiting and colonizing the gastrointestinal tract, including bacteria, archaea, and eukarya.1 This intricate microbial ecosystem exists in a symbiotic relationship with the host, with trillions of microorganisms playing key roles in maintaining human health.2 Firmicutes and Bacteroidetes represent the predominant bacterial phyla that form the intestinal microbiome.2 The gut microbiota has developed adaptive mechanisms to promote its survival within the gastrointestinal tract. Development of the intestinal microbiome has been depicted and seems to be influenced by a variety of factors, e.g., mode of delivery, diet during infancy and adulthood, illnesses, and antibiotic treatment causing variation in the composition of the microbiota.3 Before the age of three, children’s intestinal microbiome already resembles the gut microbiota of adult individuals in terms of functional capabilities, diversity, and composition.4 The gut microbiota offers numerous benefits to the host as its metabolic activity is responsible for the generation of short-chain fatty acids which are a source of energy for the host, and for the fermentation of carbohydrates leading to the synthesis of oxalates, reducing the risk of oxalate stones in the kidney.5 In addition, the microbiota promotes lipid metabolism, vitamin synthesis, polyphenol breakdown, drug metabolism, immunomodulation, which offers immune-protection, and maintains the structural integrity of the gastrointestinal tract.3 Therefore, the gut microbiota represents an intricate microbial ecosystem that plays a critical role in maintaining human health.
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Association of vascular endothelial growth factor a gene (VEGFA) polymorphisms, rs699947 and rs1570360, with diabetic retinopathy and altered VEGF secretion in the Pakistani patients with type 2 diabetes mellitus: a case-control study
Authors: Shazia Qayyum  , Muhammad Afzal  , Abdul Khaliq Naveed  , Butt Imran Azam , Madiha Sajjad  , Moiz Azam
Published: December 2023

Objective: To investigate the association of vascular endothelial growth factor A gene polymorphisms 2578C/A (rs699947) and 1154G/A (rs1570360) with type 2 diabetes mellitus, diabetic retinopathy and serum vascular endothelial growth factor levels in Pakistani patients.
Method: The case-control study was conducted from Jan 2017 to Dec 2018 after approval from the ethics review board of Riphah International University, Islamabad, Pakistan, and comprised type 2 diabetes mellitus patients of either gender with diabetic retinopathy in group A, and without diabetic retinopathy in group B. Non-diabetic healthy individuals were enrolled in control group C. Genotyping was done by amplification refractory mutation system-polymerase chain reaction and serum vascular endothelial growth factor levels were measured using enzyme-linked immunosorbent assay. Data was analysed using SPSS 22.
Results: Of the 450 subjects, 150(33.3%) were in each of the 3 groups. The mean age in group A was 58.16±9.42, in group B 56.25±8.5 years and in group C it was 55.90±10.90. The proportion of Punjabi ethnicity was significantly high in group B compared to other groups (p<0.05). There was no significant association of rs699947 and rs1570360 genotypic and allelic frequencies in group B compared to group A. Further, rs699947 AA genotype was significantly associated with proliferative diabetic retinopathy compared to group A (p<0.05). Minor allele A showed significant association in groups A and B compared to group C (p<0.05). Significantly raised serum vascular endothelial growth factor levels were found in group B compared to group A (p<0.05), and were associated with rs699947 and rs1570360 heterozygosity in group A (p<0.05). Also, rs699947 genotype showed significant association with groups A and B in Punjabi and Pathan ethnicities (p<0.05) and with Kashmiri ethnicity in group B (p<0.05).
Conclusion: There was a strong association of vascular endothelial growth factor 2578C/A (rs699947) gene polymorphism with proliferative diabetic retinopathy in type 2 diabetic Pakistani patients, suggesting its role in the pathogenesis of this condition.
Key Words: Diabetic retinopathy, Polymorphisms, Type 2 diabetes mellitus, Vascular endothelial growth factor A gene.