bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving the understanding of cytoneme-mediated morphogen gradients by in silico modeling
Authors: Aguirre-Tamaral Adrián , Guerrero Isabel
Published: August 2021

Morphogen gradients are crucial for the development of organisms. The biochemical properties of many morphogens prevent their extracellular free diffusion, indicating the need of an active mechanism for transport. The involvement of filopodial structures (cytonemes) has been proposed for morphogen signaling. Here, we describe an in silico model based on the main general features of cytoneme-meditated gradient formation and its implementation into Cytomorph, an open software tool. We have tested the spatial and temporal adaptability of our model quantifying Hedgehog (Hh) gradient formation in two Drosophila tissues. Cytomorph is able to reproduce the gradient and explain the different scaling between the two epithelia. After experimental validation, we studied the predicted impact of a range of features such as length, size, density, dynamics and contact behavior of cytonemes on Hh morphogen distribution. Our results illustrate Cytomorph as an adaptive tool to test different morphogen gradients and to generate hypotheses that are difficult to study experimentally.
Psychological impact of COVID-19 and lock down measures: An online cross-sectional multicounty study on Asian university students
Authors: Chinna Karuthan , Sundarasen Sheela , Khoshaim Heba Bakr , Kamaludin Kamilah , Nurunnabi Mohammad , Baloch Gul Mohammad , Hossain Syed Far Abid , Sukayt Areej , Dalina Nevi , Rajagopalan Usha , Kumar Ramesh , Memon Zahid
Published: August 2021

The COVID-19 pandemic and the lockdown measures have taken a toll on every level of the society, worldwide. This study examines their psychological impact on university students in Asia. A cross-sectional online survey was conducted between April and May 2020 in Malaysia, Saudi Arabia, Pakistan, Bangladesh, China, India and Indonesia. The Zung’s self-rating anxiety scale (SAS) and questions on adaptive and maladaptive coping strategies were used in this study. A total of 3,679 students from the seven countries participated in this study. Overall, 21.9% and 13.7% of the students in this study experienced mild to moderate and severe to extreme levels of anxiety. More than 20% of the students from China and Bangladesh reported severe to extreme level of anxiety compared to below 10% of the students from Indonesia, Malaysia and India. Among the female students, 15.9% experienced severe to extreme level of anxiety compared to 10.6% among the males. Females from Bangladesh, China, Malaysia, Pakistan and Saudi Arabia experienced significantly higher levels of anxiety compared to their male counterparts. Acceptance was the most used and Seeking Social Support was the least used coping strategies among the students. There were significant differences in the usage of the four strategies by countries. Stressors are predominantly financial constraints, remote online learning, and uncertainty related to their academic performance, and future career prospects.
Impact of large choroidal vessels on choriocapillaris flow deficit analyses in optical coherence tomography angiography
Authors: Hacker Valentin , Reiter Gregor Sebastian , Schranz Markus , Told Reinhard , Reumüller Adrian , Hofer Dominik , Steiner Irene , Schmidt-Erfurth Ursula , Sacu Stefan
Published: August 2021

Purpose

To investigate the impact of large choroidal vessels (LCV) on Choriocapillaris (CC) flow deficit (FD) analyses with swept-source optical coherence tomography angiography (SS-OCTA)

Design

Prospective, cross-sectional study.

Methods

Macular 6x6mm SS-OCTA scans were obtained from intermediate age-related macular degeneration (iAMD) and healthy eyes. Images were captured and processed according to most common standards and analyzed for percentage of flow-deficits (FD%) within four 1x1mm squares at the corners of each image. Choroidal thickness (CT), iris color and refraction error were considered as potential influential factors for LCV visibility. A linear mixed model and logistic regression models were calculated for statistical evaluation.

Results

Sixty-nine iAMD and 49 age-matched healthy eyes were enrolled. LCV were visible in at least one sector in 52% of iAMD and 47% of healthy eyes. Within the iAMD group FD% were significantly lower in areas containing LCV (p = 0.0029). Increasing CT resulted in an odds ratio decrease of LCV (OR: 0.94, p<0.0001). Below a CT value of ≤118μm LCV could be expected with a sensitivity of 86% and a specificity of 85%.

Conclusions

LCV can significantly affect CC FD analyses of SS-OCTA images. Their visibility is negatively associated with CT. The impact of LCV should be taken into account when performing CC FD assessments, especially in patients where reduced CT is to be expected and inclusion of affected areas should be considered carefully.
Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients
Authors: Leon-Abarca Juan Alonso , Portmann-Baracco Arianna , Bryce-Alberti Mayte , Ruiz-Sánchez Carlos , Accinelli Roberto Alfonso , Soliz Jorge , Gonzales Gustavo Francisco
Published: August 2021

Aims

The objective of this study is to analyze how the impact of Diabetes Mellitus [DM] in patients with COVID-19 varies according to altitudinal gradient.

Methods

We obtained 1,280,806 records from adult patients with COVID-19 and DM to analyze the probability of COVID-19, development of COVID-19 pneumonia, hospitalization, intubation, admission to the Intensive Care Unit [ICU] and case-fatality rates [CFR]. Variables were controlled by age, sex and altitude of residence to calculate adjusted prevalence and prevalence ratios.

Results

Patients with DM had a 21.8% higher prevalence of COVID-19 and an additional 120.2% higher prevalence of COVID-19 pneumonia. The adjusted prevalence was also higher for these outcomes as well as for hospitalization, intubation and ICU admission. COVID-19 and pneumonia patients with DM had a 97.0% and 19.4% higher CFR, respectively. With increasing altitudes, the probability of being a confirmed COVID-19 case and the development of pneumonia decreased along CFR for patients with and without DM. However, COVID-19 patients with DM were more likely to require intubation when residing at high altitude.

Conclusions

The study suggests that patients with DM have a higher probability of being a confirmed COVID-19 case and developing pneumonia. Higher altitude had a protective relationship against SARS-CoV-2 infection; however, it may be associated with more severe cases in patients with and without DM. High altitude decreases CFR for all COVID-19 patients. Our work also shows that women are less affected than men regardless of altitude.
University students’ perspectives, planned uptake, and hesitancy regarding the COVID-19 vaccine: A multi-methods study
Authors: Mant Madeleine , Aslemand Asal , Prine Andrew , Jaagumägi Holland Alyson
Published: August 2021

Purpose

To investigate university students’ willingness to receive a COVID-19 vaccine when it becomes available to them.

Method

A multi-methods approach was used—online convenience sample surveys and semi-structured interviews—of young adults attending a large Canadian public university. Two survey samples were collected (June 20-July 28, 2020 and September 22-October 17, 2020). Semi-structured interviews were conducted following each survey, interviewing 20 students in each round.

Results

In June 77.8% of surveyed students (n = 483) were willing to get the COVID-19 vaccine; in September 79.6% were willing (n = 1269). Multinomial and binary logistic regression analyses found that increasing perception of the severity of COVID-19 predicted the likelihood that a respondent was willing to get the COVID-19 vaccine in both surveys. In the latter survey students who indicated they would be encouraged to get the COVID-19 vaccine if their doctor/pharmacist recommended it were 76 times more likely to be willing to get the vaccine than those who would not be encouraged by medical advice. Interviews revealed concerns about the speed of the vaccine roll out, safety, and efficacy.

Conclusions

The majority of university students intend to get the COVID-19 vaccine, but there are nuanced concerns about efficacy and safety that must be taken into account by public health authorities as the vaccine becomes available to this group. Ensuring that family doctors, pharmacists, and other front-line healthcare workers have consistent and clear information regarding the benefits of vaccination will be critical to encouraging uptake among young adults.
Changes and prognostic value of cardiopulmonary exercise testing parameters in elderly patients undergoing cardiac rehabilitation: The EU-CaRE observational study
Authors: Marcin Thimo , Eser Prisca , Prescott Eva , Prins Leonie F. , Kolkman Evelien , Bruins Wendy , van der Velde Astrid E. , Peña Gil Carlos , Iliou Marie-Christine , Ardissino Diego , Zeymer Uwe , Meindersma Esther P. , Van’t Hof Arnoud W. J. , de Kluiver Ed P. , Wilhelm Matthias
Published: August 2021

Objective

We aimed 1) to test the applicability of the previously suggested prognostic value of CPET to elderly cardiac rehabilitation patients and 2) to explore the underlying mechanism of the greater improvement in exercise capacity (peak oxygen consumption, VO2) after CR in surgical compared to non-surgical cardiac patients.

Methods

Elderly patients (≥65 years) commencing CR after coronary artery bypass grafting, surgical valve replacement (surgery-group), percutaneous coronary intervention, percutaneous valve replacement or without revascularisation (non-surgery group) were included in the prospective multi-center EU-CaRE study. CPETs were performed at start of CR, end of CR and 1-year-follow-up. Logistic models and receiver operating characteristics were used to determine prognostic values of CPET parameters for major adverse cardiac events (MACE). Linear models were performed for change in peak VO2 (start to follow-up) and parameters accounting for the difference between surgery and non-surgery patients were sought.

Results

1421 out of 1633 EU-CaRE patients performed a valid CPET at start of CR (age 73±5.4, 81% male). No CPET parameter further improved the receiver operation characteristics significantly beyond the model with only clinical parameters. The higher improvement in peak VO2 (25% vs. 7%) in the surgical group disappeared when adjusted for changes in peak tidal volume and haemoglobin.

Conclusion

CPET did not improve the prediction of MACE in elderly CR patients. The higher improvement of exercise capacity in surgery patients was mainly driven by restoration of haemoglobin levels and improvement in respiratory function after sternotomy.

Trial registration

Netherlands Trial Register, Trial NL5166.
Maternal HIV and syphilis are not syndemic in Brazil: Hot spot analysis of the two epidemics
Authors: Cambou Mary Catherine , Saad Eduardo , McBride Kaitlyn , Fuller Trevon , Swayze Emma , Nielsen-Saines Karin
Published: August 2021

While the annual incidence of HIV diagnosis in pregnancy in Brazil remains relatively stable, rates of maternal syphilis increased over six-fold in the past decade. We hypothesized that maternal HIV and syphilis are two distinct epidemics. Data on all cases of maternal HIV or syphilis detected in pregnancy between January 1, 2010 to December 31, 2018 were requested from the Brazilian Ministry of Health. In order to evaluate how the epidemics evolved over the time period, ArcGIS software was used to generate spatiotemporal maps of annual rates of detection of maternal HIV and syphilis in 2010 and 2018. We utilized Euclidean-distance hot spot analysis to identify state-specific clusters in 2010 and 2018. From 2010 to 2018, there were 66,631 cases of maternal HIV, 225,451 cases of maternal syphilis, and 150,414 cases of congenital syphilis in Brazil. The state of Rio Grande do Sul had the highest rate of maternal HIV detection in both 2010 and 2018. Hot spots of maternal HIV were identified in the three most Southern states in both 2010 and 2018 (99% confidence, z-score >2.58, p <0.01). While syphilis incidence >30 per 1,000 live births in 2018 in four states, only the two coastal states of Rio de Janeiro and Espirito Santo in Southeastern Brazil were significant hot spots (90% confidence, z-score 1.65–1.95, p <0.10). Contrary to the general assumption, HIV and syphilis epidemics in Brazil are not syndemic in pregnant women. There is a spatial cluster of maternal HIV in the South, while syphilis is increasing throughout the country, more recently on the coast. Focusing on maternal HIV hot spots in the Southern states is insufficient to curtail the maternal and congenital syphilis epidemics throughout the country. New strategies, including ongoing hot spot analysis, are urgently needed to monitor, identify and treat maternal syphilis.
Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining
Authors: Yu Lulu , Majerciak Vladimir , Xue Xiang-Yang , Uberoi Aayushi , Lobanov Alexei , Chen Xiongfong , Cam Maggie , Hughes Stephen H. , Lambert Paul F. , Zheng Zhi-Ming
Published: August 2021

MmuPV1 is a useful model for studying papillomavirus-induced tumorigenesis. We used RNA-seq to look for chimeric RNAs that map to both MmuPV1 and host genomes. In tumor tissues, a higher proportion of total viral reads were virus-host chimeric junction reads (CJRs) (1.9‰ - 7‰) than in tumor-free tissues (0.6‰ - 1.3‰): most CJRs mapped to the viral E2/E4 region. Although most of the MmuPV1 integration sites were mapped to intergenic regions and introns throughout the mouse genome, integrations were seen more than once in several genes: Malat1, Krt1, Krt10, Fabp5, Pard3, and Grip1; these data were confirmed by rapid amplification of cDNA ends (RACE)-Single Molecule Real-Time (SMRT)-seq or targeted DNA-seq. Microhomology sequences were frequently seen at host-virus DNA junctions. MmuPV1 infection and integration affected the expression of host genes. We found that factors for DNA double-stranded break repair and microhomology-mediated end-joining (MMEJ), such as H2ax, Fen1, DNA polymerase Polθ, Cdk1, and Plk1, exhibited a step-wise increase and Mdc1 a decrease in expression in MmuPV1-infected tissues and MmuPV1 tumors relative to normal tissues. Increased expression of mitotic kinases CDK1 and PLK1 appears to be correlated with CtIP phosphorylation in MmuPV1 tumors, suggesting a role for MMEJ-mediated DNA joining in the MmuPV1 integration events that are associated with MmuPV1-induced progression of tumors.
From historical materiality to performance: Choreographic functions of the costumes in The Rite of Spring (1913)
Authors: Järvinen Hanna
Published: August 2021

Examining the surviving costumes of the 1913 production of The Rite of Spring, this article explores how costumes functioned in the Russian ‘new ballet’ choreography, of which the Ballets Russes Company is the most internationally famous example. The materiality of costumes – the fabric, cut and dye – organized the dancing bodies onstage in a manner that, in part, relied on Russian contexts invisible to the predominantly foreign audiences of the performances in Paris and London. Subsequently, these Russian reactions where The Rite of Spring was part of a continuum of representations of Russia’s past have been largely ignored in favour of the opinions of French and British critics, for whom the work appeared extraordinary and alien. The so-called reconstruction (1987), where the surviving costumes were used to compensate for the absence of choreographic understanding, has further obscured what the choreography was and what costumes actually did (and do) in performance. Although decisions made in recreating performance differ from historiographical research, exploring the practical making of costumes also draws attention to perspectives often forgotten in discussions of past performance more generally – such as changes in how costumes are experienced, or what that experience explains of later reminiscences.
Efficacy of sentinel lymph node biopsy with radioisotope alone and the prediction of sentinel node status using PET-CT in breast cancer
Authors: Song Ran , Kwon Seong Uk , Yoon Dae Sung , Bae In Eui , Choi In Seok , Choi Won Jun , Lee Sang Eok , Moon Ju Ik , Sung Nak Song , Lee Seung Jae , Roh Seung Jae , Kim Sung Gon
Published: August 2021

Purpose: Sentinel lymph node biopsy (SLNB) using both a radioactive isotope (RI) and blue dye is considered highly effective; however, there were limitations with the use of both agents in some hospitals, and blue dye has been shown to have some adverse effects. Additionally, preoperative prediction of sentinel lymph node (SLN) status using the maximum standardized uptake value (SUVmax) on positron emission tomography-computed tomography (PET-CT) can help avoid unnecessary axillary dissection or SLNB. Thus, we evaluated the efficacy and oncologic safety of SLNB using an RI alone in terms of long-term outcomes and determined the association between SLN metastasis and SUVmax of the primary tumor.Methods: This retrospective study was conducted at Konyang University Hospital between March 2011 and May 2018. Overall, 142 patients with breast cancer who underwent SLNB using an RI alone were enrolled. Data on identification and false-negative rates were collected. The SUVmax of primary tumors on PET-CT were analyzed for their association with SLN metastasis.Results: The identification and false-negative rates were 98.6% and 0%, respectively. There was no axillary local recurrence in patients with negative SLN findings. The correlation between the SUVmax of the primary tumor and SLN status was significant (r=0.249, P=0.005); the cutoff value for negative SLN metastasis was <2.15.Conclusion: The single agent method using an RI is not inferior to other methods and serves as a feasible option for SLNB. And the number of excised SLNs could be minimized when the SUVmax of primary tumor is extremely low.
Tumor grade 2 as the independent predictor for lymph node metastasis in 10–20 mm sized rectal neuroendocrine tumor
Authors: Park Byung-Soo , Cho Sung Hwan , Son Gyung Mo , Kim Hyun Sung , Kim Su Jin , Park Su Bum , Choi Cheol Woong , Kim Hyung Wook , Shin Dong Hoon
Published: August 2021

Purpose: Rectal neuroendocrine tumors (NETs) <10 mm are endoscopically resected, while those ≥20 mm are treated with radical surgical resection. The choice of treatment for 10–20 mm sized rectal NETs remains controversial. This study aimed to verify factors predicting lymph node metastasis (LNM) of 10–20 mm sized rectal NET and utilize them to decide upon the treatment strategy.Methods: Twenty-eight patients with 10–20 mm sized rectal NETs treated at Pusan National University Yangsan Hospital from January 2009 to September 2020 were divided into LNM (+) and LNM (–) groups, and their respective data were analyzed.Results: Seven patients (25%) had LNM while 21 patients (75%) did not. Endorectal ultrasound findings showed tumor size was significantly larger in the LNM (+) than in the LNM (–) group (15 mm vs. 10 mm, P=0.018); however, pathologically, there was no significant difference in tumor size (13 mm vs. 11 mm, P=0.109). The mitotic count (P=0.011), Ki-67 index (P=0.008), and proportion of tumor grade 2 patients (5 cases, 71% vs. 1 case, 5%; P=0.001) were significantly higher in the LNM (+) group. In multivariate analysis, tumor grade 2 was the independent factor predicting LNM (odds ratio, 61.32; 95% confidence interval, 3.17–1,188.64; P=0.010).Conclusion: Tumor grade 2 was the independent factor predicting LNM in 10–20 mm sized rectal NETs. Therefore, it could be considered as the meaningful factor in determining whether radical resection is necessary.
APPENDICULAR LEAN SOFT TISSUE: DEVELOPMENT AND CROSS-VALIDATION OF PREDICTIVE MODELS FOR OLDER MEN AND WOMEN
Authors: GOMES I.C. , GOBBO L.A. , SILVA A.M. , FREITAS JUNIOR I.F. , DUARTE Y.A.O. , MARUCCI M.F.N. , DOS SANTOS V. R . , LEBRAO M.L.
Published: August 2021

Background:Sarcopenia may explain, in a large proportion, physical disability, falls and fractures,especially in aged elderly. However, a diagnosis in an operationally systematic, simple and low cost way isextremely important, particularly for home-based, epidemiological studies. Objective:The purpose of this studywas to develop and validate predictive equations of appendicular lean soft tissue (ALST) in elderly older than 80years. Design and settings:A validation study was performed in 106 elderly (men and women) aged 80 years andolder. Measurements:Body weight, height, circumference (arm, midcalf, hip and waist) and triceps skinfold weremeasured in the elderly. ALST were measured using as the reference method dual-energy X-ray absorptiometry(DXA). Results:Two models were predicted. The first model (ALST, in kg = 0.074*height + 0.277*weight –0.144*triceps skinfold – 0.103*waist circumference + 1.831*gender -0.966), which considered all possiblevariables in stepwise multiple regression, presented better statistical performance (r2= 0.82; SEE = 1.67 kg),compared to the second model (ALST, in kg = 0.138*height + 0.103*weight + 3.061*gender – 12.489), a morepractical equation, due to a lesser quantity of predictive variables (r2= 0.75; SEE = 1.94 kg). Both models werevalidated, however, it was verified trend (p<0.05) for overestimation of predicted ALST. Conclusion:Insummary, two models for predicting ALST in men and women with age ≥ 80 years were developed and cross-validated. Model 1, with a greater number of predictive variables, presented a better accuracy than did the modelwith only three variables (height, weight, and gender). Validation studies are needed to test the usefulness of bothmodels in other populations.
THE COYOACAN COHORT STUDY: DESIGN, METHODOLOGY, AND PARTICIPANTS’ CHARACTERISTICS OF A MEXICAN STUDY ON NUTRITIONAL AND PSYCHOSOCIAL MARKERS OF FRAILTY
Authors: RUIZ-ARREGUI L. , ÁVILA-FUNES J.A. , AMIEVA H. , BORGES-YÁÑEZ S.A. , VILLA-ROMERO A. , AGUILAR-NAVARRO S. , PÉREZ-ZEPEDA M.U. , GUTIÉRREZ-ROBLEDO L.M. , CASTREJÓN-PÉREZ R.C.
Published: August 2021

Background:“Frailty” has emerged as a condition associated with an increased risk of functionaldecline among the elderly, which may be differentiated from aging, disability, and co-morbidities. Objective: TheMexican Study of Nutritional and Psychosocial Markers of Frailty among Community-Dwelling Elderly hasemerged to help answer many questions about frailty among the older adults. This report presents the design ofthe study and baseline data of its participants. Design: The “Coyoacan cohort” is a longitudinal observationalstudy developed in Mexico City. Participants:A representative sample of 1,294 non-institutionalized men andwomen aged 70 years and older were randomly recruited to undergo a face-to-face interview and acomprehensive geriatric assessment (including clinical evaluations and blood samples) between 2008 and 2009.Measurements:Data collected included socio-demographic and economic characteristics, medical history, oralhealth, drug use, cognitive function and mood, nutritional status, physical performance and functional status,physical activity, quality of life, social networks, and biological data. Frailty was defined as the presence of ≥3 ofthe following components: slowness, poor muscle strength, low physical activity, exhaustion and unintentionalweight loss. Results: A total of 1,124 participants completed the interview. The mean age was 79.5 ± 7.1 years,and 55.9% were female. Nine hundred and forty-five subjects completed the clinical evaluation and 743 bloodsamples were collected. The baseline prevalence of frailty was 14.1%. Conclusions:Understanding the medical,biological, and environmental factors that contribute to the phenomenon of frailty is the goal of the currentresearch in the field.
EVALUATING RESPONSE MECHANISMS IN A LIFE-SPACE MOBILITY INSTRUMENT WITH A ‘STEM AND LEAF’ FORMAT
Authors: SIORDIA C.
Published: August 2021

Background: Life-space mobility scales in the very old (aged 80+) have begun to be used as a way ofgauging their enacted mobility. Objectives:To investigate if there is evidence that response patterns are beingaffected by the “stem and leaf” format of a life-space mobility instrument. Methods:Descriptive statistics,readability ease scoring, ten ordinary least square regression on a total of 698 females and 376 males from Wave-7 collected during 2010-2011 for the Hispanic Established Population for the Epidemiological Study of theElderly. Results:Response patterns seem to indicate that the stem and leaf format of the life-space mobilityinstrument is not creating item non-response, illogical responses, or ‘no’ responses. Conclusions:Because self-reports are so frequently used, more research is needed to ascertain how instrument formats affect responsemechanisms.
Assessment of Organ and Tissue Procurement Knowledge in Health Care Workers Associated to Critical and Emergency Care Units
Authors: Álvarez-Manduca Katty , Patino-Jaramillo Nasly , García-Lopéz Andrea , Girón-Luque Fernando
Published: August 2021

Objetivo: Evaluar el nivel de conocimiento de profesionales en salud frente a la donación de órganos y tejidos en Barranquilla. Metodología: Estudio de corte transversal con encuesta semiestructurada sobre el conocimiento de la donación de órganos y tejidos en el personal de salud entre junio hasta diciembre de 2019. Se incluyen 232 profesionales de la salud en los servicios de Unidad de Cuidado Intensivo (UCI) adultos o pediátrica y Urgencias en seis Instituciones Prestadoras de Salud (IPS) de Barranquilla. Resultados: El 75 % de nuestros encuestados fueron mujeres. Se incluyó auxiliares de enfermería (43,5 %), profesionales en enfermería (25,4 %), médicos (22,8 %) y fisioterapeutas (8,2 %). El 84,5 % de los evaluados definió correctamente la muerte encefálica (ME); 50,4 % tiene conocimiento adecuado sobre la presunción en donación; el 52,4 % identifica apropiadamente la legislación, y el 78,9% conoce la activación de alerta en donación. No se encontraron resultados estadísticamente significativos en nivel de conocimiento comparado entre IPS (p=0.42), aunque se encontró una diferencia entre el concepto de presunción legal de la donación entre los servicios UCI adulto, pediátrica y Urgencias (p=0.000) y la definición de ME entre los profesionales asociados (p=0.001). Conclusión: Este diagnóstico del nivel de conocimiento en donación y trasplantes identificó una contundente necesidad de educación y entrenamiento continuo que podría ser gestionada con esfuerzos regionales en pro del mejoramiento del proceso y la tasa de donación de órganos y tejidos.
Spontaneous Left Talamic Hemorrhage: Illustrative Case
Authors: Abuabara Franco Emilio , Bohórquez Rivero José , Restom Arrieta José , Llanos Almario Kevin , Montoya Jaramillo Mario , Moscote Salazar Luis Rafael , Cedano Vélez Nikolle
Published: August 2021

La hemorragia talámica pertenece al grupo de las hemorragias intracerebrales de etiología no traumática o quirúrgica. Es una entidad relativamente infrecuente y tiene una prevalencia de 6-15 % de los casos dentro de dicho grupo. El tálamo es una estructura anatómica donde convergen múltiples vías neuronales, por lo tanto, sus manifestaciones clínicas no están totalmente descritas. A pesar de ello, se conoce que su presentación clínica más frecuente está asociada al síndrome sensitivo de Déjerine-Roussy, caracterizado por intenso dolor neuropático, alodinia contralateral a la lesión, hemiparesia y hemiataxia. La hemorragia talámica también se puede presentar con alteraciones de la memoria, sueño, emociones y procesamiento de información sensitiva. Se presenta un caso de hemorragia talámica izquierda espontánea en un paciente de 71 años que debutó con cambios en su comportamiento, bradipsiquia y amnesia anterógrada, con posterior recuperación completa de su estado cognitivo y psicológico antes de los 8 días y con hallazgos normales en la panangiografía.
Spontaneous Left Talamic Hemorrhage: Illustrative Case
Authors: Abuabara Franco Emilio , Bohórquez Rivero José , Restom Arrieta José , Llanos Almario Kevin , Montoya Jaramillo Mario , Moscote Salazar Luis Rafael , Cedano Vélez Nikolle
Published: August 2021

La hemorragia talámica pertenece al grupo de las hemorragias intracerebrales de etiología no traumática o quirúrgica. Es una entidad relativamente infrecuente y tiene una prevalencia de 6-15% de los casos de dicho grupo. El tálamo es una estructura anatómica donde convergen múltiples vías neuronales, por lo tanto, sus manifestaciones clínicas no están totalmente descritas. A pesar de ello, se conoce que su presentación clínica más frecuente está asociada al síndrome sensitivo de Déjerine-Roussy, caracterizado por intenso dolor neuropático, alodinia contralateral a la lesión, hemiparesia y hemiataxia. La hemorragia talámica también se puede presentar con alteraciones de la memoria, sueño, emociones y procesamiento de información sensitiva. Se presenta un caso de hemorragia talámica izquierda espontanea en un paciente de 71 años que debutó con cambios en su comportamiento, bradipsiquia, y amnesia anterógrada, con posterior recuperación completa de su estado cognitivo y psicológico antes de los 8 días y con hallazgos normales en la panangiografía.
THE STRATEGY FOR THE DEVELOPMENT OF KAMPUNG LABU MADU AGROTOURISM IN BESUK HAMLET, TOYORESMI VILLAGE, NGASEM DISTRICT, KEDIRI REGENCY, EAST JAVA PROVINCE, INDONESIA
Authors: Hamyana Hamyana , Budianto Budianto , Hidayawati Khanifatul
Published: August 2021

The phenomenon of the declining interest of young workers working in the agricultural sector has consequences for the sustainability of the agricultural sector going forward. In the future, the burden on the agriculture sector will be heavier with the inc reasing population and increasing food demand. The reasons for the decline in the interest of young workers works at agricultural sector are mainly caused by the image of the agricultural sector which is less prestigious and can not provide adequate rewards. The crisis of young farmers in the agricultural sector and the predominance of older farmers has consequences for the agriculture sector development, particularly on agricultural productivity, market competitiveness, ruraleconomic capacity, and further it will threaten food security and agricultural sector sustainability. The objective of the research is to know the effect of social to career prospects on agricultural career empirically. The research involves 110 respondents with a questionnaire as a research instrument. The type of research in this study is survey research, the type of research which the way to collect data obtained or collected from the sample or population under study. Testing is done with a regression test to determine the effect of social status on career prospects in agriculture. The results of this study indicate that social status has an influence on perceptions of career prospects in the agricultural sector.
PERCEPTIONS OF STUDENTS OF THE FACULTY OF AGRICULTURE ON THE SOCIAL STATUS AND CAREER PROSPECTS IN THE AGRICULTURAL SECTOR
Authors: Zulaikha Yasinta , Martono Edhi , Himam Fathul
Published: August 2021

The phenomenon of the declining interest of young workers working in the agricultural sector has consequences for the sustainability of the agricultural sector going forward. In the future, the burden on the agriculture sector will be heavier with the inc reasing population and increasing food demand. The reasons for the decline in the interest of young workers works at agricultural sector are mainly caused by the image of the agricultural sector which is less prestigious and can not provide adequate rewards. The crisis of young farmers in the agricultural sector and the predominance of older farmers has consequences for the agriculture sector development, particularly on agricultural productivity, market competitiveness, ruraleconomic capacity, and further it will threaten food security and agricultural sector sustainability. The objective of the research is to know the effect of social to career prospects on agricultural career empirically. The research involves 110 respondents with a questionnaire as a research instrument. The type of research in this study is survey research, the type of research which the way to collect data obtained or collected from the sample or population under study. Testing is done with a regression test to determine the effect of social status on career prospects in agriculture. The results of this study indicate that social status has an influence on perceptions of career prospects in the agricultural sector.
MARKETING OF VEGETABLES THROUGH E-COMMERCE IN BALI PROVINCE
Authors: Trisna Anak Agung Inten , Ustriana I Nyoman Gede , Arisena Gede Mekse Korri
Published: August 2021

BPS National Socioeconomic Survey of Province Bali in 2016 to 2017 years, explains the order of foodstuffs (staple foods) with the highest level of consumption after grains are vegetables.Marketing vegetable in the Province Bali were still conventional, compared to some regions in Java which was increasingly aggressively marketing agricultural products with e-commerce. The purpose of this study is to examine the profile of e-commerce users. This research was explained characteristics, marketing management activities on the e-commerce platform, easy of used, e-commerce adoption and business success. This research was conducted on the e-commerce platforms Facebook, Instagram, Tokopedia, and Shopee. The research sample of 30 vegetable traders using e-commerce, analyzed using qualitative descriptive methods and Partial Least Squares (PLS). The results showed that most traders had a relatively young age with a degree of undergraduate education. E-commerce can increase merchant income by applying management principles to the marketing process, payment, delivery, promotion, price, marketing targets and product standardization. The results of the study can provide recommendations to the younger generation that e-commerce of agricultural products in business is very promising.
ANALYSIS OF FACTORS AFFECTING PRODUCTION AND REVENUE OF TUBEROSE (Polianthes tuberosa L.) FARMERS IN PRODUCTION CENTER OF CENTRAL JAWA
Authors: Mulyani Ani , Ekowati Titik , Purbajanti Endang Dwi
Published: August 2021

The purpose of this research is to analysis the effect of using production factors, farmer income and feasibility on Tuberoses flower (Polianthes tuberosa L.) crops. Research used census method and the number of sampel are 30 respondents, in Semarang and Magelang regency. Analysis of research used  Cobb-douglas model of production function,  linier regression function and one sample t test.The results of the   analysis of production function showed the amount of seeds, organic fertilizer,  NPK fertilizer, labor and the water have significant effect. The results of the analysis of the income function that have significant effect were the price and the amount of production,  this means, if increase in prices or increase in production, the farmer's income will increase. One samplet t-test results showed tuberose flowers farming was profitable and feasible to be developed
RELIGIOUS BEHAVIOR OF AGRARIAN COMMUNITY IN LINGSAR VILLAGE, LOMBOK BARAT
Authors: Jayadi Suparman , Rahmawati Ratih
Published: August 2021

research aimed to analyze work ethos and Sasak Islam religious behavior of agrarian community in Lingsar Village of Lombok Barat, Nusa Tenggara Barat. Sasak Islam religious behavior and work ethos of agrarian community in farming practice was the unit of analysis in this qualitative research with case study approach. Data collection was carried out through observation, in-depth interview, and documentation. To validate data, multisource evidence was used and analyzed with Weber’s social action theory. The result of research showed that religious behavior of Lingsar village’s farmer community included nerimaq (grateful), cukup (feeling enough), and ikhlas (sincere). Work ethos could be seen in social action such as working hard and diligently and farming processing land well. There was a relationship between farmer’s work ethos and Sasak Islam religious understanding of agrarian community in Lingsar Village.
KEBIJAKAN PENANGGULANGAN HIV/AIDS YANG BERKEADILAN: SEBUAH TELAAH FEMINIST LEGAL THEORY
Authors: Natalis Aga , Wibawa Kadek Cahya Susila
Published: August 2021

Pengakuan bahwa ketidaksetaraan mungkin menjadi pendorong kerentanan seseorang atau sekelompok orang atas HIV/AIDS, misalnya ketidaksetaraan gender dalam bidang pendidikan dan pembatasan otonomi sosial di kalangan perempuan secara langsung terkait dengan akses yang lebih rendah ke layanan kesehatan seksual, termasuk tes dan pengobatan HIV. Ketidaksetaraan tersebut menimbulkan serangkaian tanggapan Feminist Legal Theory di sebuah upaya untuk mengatasi HIV. Tujuan dari penelitian ini adalah untuk untuk menganalisis mengenai kebijakan penanggulangan HIV/AIDS yang berkeadilan dalam telaah Feminist Legal theory. Metode penelitian yang digunakan adalah metode kualitatif dengan jenis penelitian doktrinal/normatif serta pendekatan filosofi. Hasil penelitian menunjukkan bahwa etika feminis mungkin sangat relevan dengan etika kesehatan masyarakat. Berangkat dari cara pandang feminist legal theory, maka pembuatan kebijakan penenanggulangan HIV/AIDS harus dilakukan berbasis pada people with HIV-centered social policies, yang menekankan bahwa dalam proses pembuatan suatu kebijakan haruslah berorientasi pada kesejahteraan ODHA.
ANALISIS QOS DAN QOE PADA VIDEO PEMBELAJARAN ONLINE DI INSTITUT TEKNOLOGI TELKOM PURWOKERTO (ITTP)
Authors: Masykuroh Kholidiyah , Ramadhani Afifah Dwi , Iryani Nanda
Published: August 2021

Pandemi COVID-19 memberikan dampak pada berbagai aspek kehidupan yang mengakibatkan pembatasan ruang gerak manusia, salah satunya pada dunia pendidikan. Kebiasaan baru dengan balajar dari rumah harus didukung dengan kualitas jaringan bagus. Kualitas jaringan yang bagus dapat diukur melalui parameter QoS. Selain itu, kondisi jaringan yang bagus tentunya sesuai dengan tingkat layanan di sisi pengguna. Pada penelitian ini kami mengukur QoS dan QoE. Parameter QoS yang digunakan meliputi throughput, packet loss, delay, dan jitter. Sedangkan parameter QoE yang digunakan adalah MOS. Berdasarkan hasil pengujian yang dilakukan pada 2 video, menunjukkan bahwa parameter-parameter tersebut masih berada pada nilai standar yang digunakan oleh ITU-T G.1010. Sedangkan berdasarkan hasil survei yang dilakukan pada mahasiswa dan dosen di IT Telkom Purwokerto didapatkan hasil MOS menunjukkan bahwa video pembelajaran online memiliki kualitas yang bagus.
PERANCANGAN HEXACOPTER UNTUK MENGAMBIL BARANG MENGGUNAKAN SENSOR LIDAR LITE V3
Authors: Hasan Geri Asbi , Akbar Son Ali
Published: August 2021

Pada Penelitian ini merancang sebuah hexacopter (Drone) yang dapat mengambil barang dengan menggunakan sensor Lidar Lite v3 yang berfungsi untuk menambah tingkat keakuratan dalam mengukur jarak objek sedangkan sebagai pusat kendali pada hexacopter menggunakan flight controller Pixhawk. Hexacopter yang dirancang akan  mengambil sebuah barang menggunakan sistem mekanik gripper dengan penggerak yaitu motor servo karena melihat spesifikasi dari motor servo lebih dapat menangani arus yang tinggi atau beban berat, Motor servo dikendalikan dengan memberikan sinyal modulasi lebar pulsa melalui kabel kontrol. hexacopter ini menggambil barang secara semi otomatis dengan acuan jarak pada pembacaan sensor Lidar Lite v3. Perancangan pada hexacopter untuk mengambil barang berupa survival kits ini bertujuan untuk mengurangi tugas manusia dalam pengiriman cepat barang menggunakan jalur udara. Dari hasil pengujian yang telah dilakukan dapat disimpulkan bahwa hexacopter (drone) ini dapat berjalan dengan baik pada saat mengambil barang tersebut dengan mekanik gripper dan motor servo sebagai penggerak.Kesimpulan dari alat yang dirancang sebagai media angkut barang berupa survival kits melalui jalur udara, mekanik penggerak gripper dapat diaplikasikan menggunakan beberapa motor servo.
ANALISIS PENGARUH AIR GAP (CELAH UDARA) TERHADAP UNJUK KERJA GENERATOR AXIAL FLUX DOUBLE SIDE ROTOR 1 FASA DENGAN KUTUB BERLAWANAN (N-S)
Authors: Khikmah Qoidatul , Hadi Widyono , Cahyadi Widya
Published: August 2021

Energi terbarukan skala kecil sebagai sumber energi listrik alternatif hanya mampu membangkitkan energi mekanik yang rendah. Penggunaannya membutuhkan generator jenis axial flux permanent magnet (AFPM) yang dapat bekerja pada putaran rendah. Beberapa studi telah dilakukan tentang generator axial flux seperti dalam rancang bangun dan penelitian beberapa parameter yang mempengaruhi performa generator. Celah udara merupakan parameter penting yang dapat mempengaruhi kinerja generator. Penelitian ini dilakukan dengan memberikan variasi celah udara sebesar 8 mm, 9 mm, dan 10 mm pada generator axial flux konstruksi double side rotor untuk membangkitkan AC 1 fasa menggunakan magnet permanen Neodymium Iron Boron (NdFeB) dan disusun secara kutub berlawanan (N-S). Dengan memberikan beban 3 LED terhubung seri pada kecepatan putar 3000 rpm, pengujian saat celah udara 8 mm diperoleh frekuensi sebesar 450.4 Hz, tegangan output 7.468 V, arus output 14.961 mA, daya output  W dan torsi rotor sebesar  Nm. Pada pengujian celah udara 9 mm diperoleh frekuensi 450,4 Hz, tegangan output 7.279 V, arus output 7.444 mA, daya output  W dan torsi rotor sebesar  Nm. Sedangkan pengujian celah udara 10 mm diperoleh frekuensi 450.4 Hz, tegangan output 6.826 V, arus output 1.298 mA, daya output   W dan torsi rotor sebesar  Nm.
Samopoznanie umysłu w chrześcijaństwie i buddyzmie
Authors: Stróżyński Mateusz
Published: August 2021

The article compares the understanding of self-knowledge of the mind in Tibetan Buddhism (in the schools of Mahamudra and Dzogchen) with the ancient, PlatonicChristian philosophy. It argues that in both traditions there are two aspects of the experience of self-knowledge: the impossibility of grasping the mind as an object and theceaseless, unavoidable awareness of the mind’s cognitive activity. The fi rst of those aspects is called by the Tibetan tradition “emptiness”, while the second – lucidity ofthe mind’s nature. In Gregory of Nyssa and Augustine of Hippo we can see a diff erence of accent in terms of the signifi cance of those two motifs, but it seems that bothphilosophers understand self-knowledge in a very similar way. Recognizing those two aspects is what brings the Buddhist and the Western traditions close to each other,while a fundamental diff erence between them lies in the fact that in the latter, selfknowledge of the mind opens a path to the experience of the infi nite mind of God, ofwhich the fi rst is an image, while in Buddhism the concept of God does not appear at all. Individual self-knowledge is treated as the experience of the nature of one, universaland absolute mind.
Effects of miR-185-5p on replication of hepatitis C virus
Authors: Huang Wei , Song Lingyan , Zhang Jingyan , Yan Xueqiang , Yan Hui
Published: August 2021

This article was designed to explore the effects and mechanisms of miR-185-5p on the replication of hepatitis C virus (HCV). Quantitative reverse transcription PCR (qRT-PCR) was performed for detecting the abundance of miR-185-5p and HCV RNA in HCV-infected primary hepatocytes and Huh7.5 cells. Dual-luciferase reporter gene assay was used for exploring the interaction between miR-185-5p and GALNT8. Western blot analyzed protein expression of GALNT8, NS3, and NS5A. miR-185-5p was remarkably downregulated in HCV-infected primary hepatocytes and Huh7.5 cells. miR-185-5p upregulation inhibited HCV RNA expression, while its inhibition promoted HCV replication. miR-185-5p induced accumulation of NS3 and NS5A in the cells. Dual-luciferase reporter gene assay verified the targeted relationship between miR-185-5p and GALNT8. In addition, the effects of overexpressing or knocking down miR-185-5p on HCV replication could be correspondingly eliminated by the overexpression or knockdown of GALNT8. miR-185-5p may target GALNT8 in JFH1-infected Huh7.5 cells and then inhibit HCV replication. miR-185-5p may be a potential target for treating HCV.
Perceived emotional and informational support for cancer: Patients’ perspectives on interpersonal versus media sources
Authors: Bol Nadine , Rising Camella J. , Weert Julia C. M. van
Published: August 2021

This study examined cancer patients’ (N = 355, 65.4 % female, Mage
 = 54.35, SDage
 = 11.25) perceived emotional and informational support from a variety of interpersonal and media sources. We recruited patients from cancer patient association websites and online cancer forums and asked them to report to what extent they received support from interpersonal and media sources. Patients rated professional sources (e. g., oncologists) and personal sources (e. g., family) as nearly equal sources of emotional support; however, professional sources were rated as significantly greater sources of informational support. Although family and oncologists were the most mentioned interpersonal sources of support, they were also the most mentioned disappointing sources. Of the media sources, online interaction sources (e. g., online support groups) were rated as nearly equivalent sources of emotional support as interpersonal sources. That patients perceived emotional support, not only informational support, from various media sources is promising since interpersonal sources can be disappointing to some patients.
A generalization of Sims’ conjecture for finite primitive groups and two point stabilizers in primitive groups
Authors: Spiga Pablo
Published: August 2021

In this paper, we propose a refinement of Sims’ conjecture concerning the cardinality of the point stabilizers in finite primitive groups, and we make some progress towards this refinement. In this process, when dealing with primitive groups of diagonal type, we construct a finite primitive group 𝐺 on Ω and two distinct pointsα,β∈Ω\alpha,\beta\in\OmegawithGα⁢β⊴GαG_{\alpha\beta}\unlhd G_{\alpha}andGα⁢β≠1G_{\alpha\beta}\neq 1, whereGαG_{\alpha}is the stabilizer of 𝛼 in 𝐺 andGα⁢βG_{\alpha\beta}is the stabilizer of 𝛼 and 𝛽 in 𝐺. In particular, this example gives an answer to a question raised independently by Cameron and by Fomin in the Kourovka Notebook.
The Mechanisms of Neolithisation of Western Europe: Beyond a South/North Approach
Authors: Hamon Caroline , Manen Claire
Published: August 2021

Up until now, the neolithisation of Western Europe during the sixth millennium BCE has mainly been approached through the characterisation of its diffusion vectors (cultural vs demic diffusion) and the emergence of technoeconomic innovations (rhythms, scenarios, and transmission). Traditionally, two primary routes of agricultural diffusion are distinguished: one extending along the Danube river corridor to the Atlantic coast (Linearbandkeramik) and the other along the Mediterranean coastal zone (Impressed Ware). To move beyond this dichotomy, this article proposes a first attempt at an integrated approach to the mechanisms of neolithisation in Western Europe, one of the few territories where it is possible, and therefore necessary, to investigate the processes that are common to both of these principal neolithisation complexes. The most widely held vision, inherited from the 1980s, of a European Neolithic that developed from east to west following a regular rhythm has progressively been replaced by a more complex model of diffusion characterised by arrhythmia and cultural reconfigurations. Despite having different origins and trajectories, the expansion of the first farmers was made possible by a number of common mechanisms.Impresso-CardialandLinearbandkeramiksocieties faced similar constraints, especially with regard to ensuring the stability of their social and economic models, while minimising the risks inherent to the colonisation of new territories. Three main mechanisms would have structured the first neolithisation phases of both spheres: a strong mobility of populations regulated to varying degrees by social rules, a strong solidarity expressed at multiple levels of interactions within each sphere, and, finally, the existence of syncretism and cultural recompositions including close and long-distance relations.