bluuebunny/crossref_metadata_2025 huggingface dataset:
Day one postoperative MRI findings following electrode placement for deep brain stimulation: analysis of a large case series
Authors: Succop Benjamin S. , Zamora Carlos , Roque Daniel Alberto , Hadar Eldad , Kessler Brice , Quinsey Carolyn
Published: December 2023

Objective

This study sought to characterize postoperative day one MRI findings in deep brain stimulation (DBS) patients.

Methods

DBS patients were identified by CPT and had their reviewed by a trained neuroradiologist and neurosurgeon blinded to MR sequence and patient information. The radiographic abnormalities of interest were track microhemorrhage, pneumocephalus, hematomas, and edema, and the occurrence of these findings in compare the detection of these complications between T1/T2 gradient-echo (GRE) and T1/T2 fluid-attenuated inversion recovery (FLAIR) magnetic resonance (MR) sequences was compared. The presence, size, and association of susceptibility artifact with other radiographic abnormalities was also described. Lastly, the association of multiple microelectrode cannula passes with each radiographic finding was evaluated. Ad-hoc investigation evaluated hemisphere-specific associations. Multiple logistic regression with Bonferroni correction (corrected p = 0.006) was used for all analysis.

Results

Out of 198 DBS patients reviewed, 115 (58%) patients showed entry microhemorrhage; 77 (39%) track microhemorrhage; 44 (22%) edema; 69 (35%) pneumocephalus; and 12 (6%) intracranial hematoma. T2 GRE was better for detecting microhemorrhage (OR = 14.82, p < 0.0001 for entry site and OR = 4.03, p < 0.0001 for track) and pneumocephalus (OR = 11.86, p < 0.0001), while T2 FLAIR was better at detecting edema (OR = 123.6, p < 0.0001). The relatively common findings of microhemorrhage and edema were best visualized by T2 GRE and T2 FLAIR sequences, respectively. More passes intraoperatively was associated with detection of ipsilateral track microhemorrhage (OR = 7.151, p < 0.0001 left; OR = 8.953, p < 0.0001 right). Susceptibility artifact surrounding electrodes possibly interfered with further detection of ipsilateral edema (OR = 4.323, p = 0.0025 left hemisphere only).

Discussion

Day one postoperative magnetic resonance imaging (MRI) for DBS patients can be used to detect numerous radiographic abnormalities not identifiable on a computed tomographic (CT) scan. For this cohort, multiple stimulating cannula passes intraoperatively was associated with increased microhemorrhage along the electrode track. Further studies should be performed to evaluate the clinical relevance of these observations.
Not a general, symptom-unspecific, transdiagnostic marker for functional symptoms: sensorimotor processing of head control is intact in chronic pain
Authors: Regnath Franziska , Biersack Katharina , Jäger Nina , Glasauer Stefan , Lehnen Nadine
Published: December 2023

Introduction

Functional disorders are prevalent in all medical fields and pose a tremendous public health problem, with pain being one of the most common functional symptoms. Understanding the underlying, potentially unifying mechanism in functional (pain) disorders is instrumental in facilitating timely diagnosis, stigma reduction, and adequate treatment options. Neuroscientific models of perception suggest that functional symptoms arise due to dysregulated sensorimotor processing in the central nervous system, with brain-based predictions dominating the eventual percept. Experimental evidence for this transdiagnostic mechanism has been established in various functional symptoms. The goal of the current study was to investigate whether erroneous sensorimotor processing is an underlying transdiagnostic mechanism in chronic (functional) pain.

Method

A total of 13 patients with chronic (functional) pain [three patients with chronic (functional) pain disorder, F45.40, ICD-10; 10 patients with chronic pain disorder with somatic and psychological factors, F45.41, ICD-10]; and 15 healthy controls performed large combined eye-head gaze shifts toward visual targets, naturally and with increased head moment of inertia. We simultaneously measured participants' eye and head movements to assess head oscillations at the end of the gaze shift, which are an established indicator of (transdiagnostic) sensorimotor processing deficits of head control.

Results

Using a Bayesian analysis protocol, we found that patients with chronic (functional) pain and control participants stabilized their heads equally well (Bayes Factor 01 = 3.7, Bayes Factor exclusion = 5.23; corresponding to substantial evidence) during all sessions of the experiment.

Conclusion

Our results suggest that patients with chronic (functional) pain do not show measurable symptom-unspecific sensorimotor processing deficits. We discuss outcome parameter choice, organ system specificity, and selection of patient diagnoses as possible reasons for this result and recommend future avenues for research.
Clinical efficacy and safety of robotic retroperitoneal lymph node dissection for testicular cancer: a systematic review and meta-analysis
Authors: Yuan Yacheng , Zhang Dawei , Ning Yiping , Luo Hengfeng , Qiu Xiaolong , Tan Yangyang , Li Yuxiang , Yang Xukai
Published: December 2023

Background

Retroperitoneal lymph node dissection (RPLND) is an effective treatment for testicular tumors. In recent years, with the development of robotics, many urological procedures performed via standard laparoscopy have been replaced by robots. Our objective was to compare the safety and efficacy of robotic retroperitoneal lymph node dissection (R-RPLND) versus Non-robotic retroperitoneal lymph node dissection (NR-RPLND) in testicular cancer.

Methods

Pubmed, Embase, Scopus, Cochrane Library, and Web of Science databases were searched for literature on robotic surgery for testicular germ cell tumors up to April 2023. The statistical and sensitivity analyses were performed using Review Manager 5.3. Meta-analysis was performed to calculate mean difference (MD), odds ratio(OR), and 95% confidence interval (CI) effect indicators.

Results

Eight studies with 3875 patients were finally included in this study, 453 with R-RPLND and 3422 with open retroperitoneal lymph node dissection (O-RPLND)/laparoscopic retroperitoneal lymph node dissection (L-RPLND). The results showed that R-RPLND had lower rates of intraoperative blood loss (MD = -436.39; 95% CI -707.60 to -165.19; P = 0.002), transfusion (OR = 0.06; 95% CI 0.01 to 0.26; P = 0.0001), total postoperative complication rates (OR = 0.39; 95% CI 0.21 to 0.70; P = 0.002), and length of stay (MD=-3.74; 95% CI -4.69 to -2.78; P<0.00001). In addition, there were no statistical differences between the two groups regarding perioperative and oncological outcomes regarding total operative time, the incidence of postoperative complications grade≥III, abnormal ejaculation rate, lymph node yield, and postoperative recurrence rate.

Conclusions

The R-RPLND and O-RPLND/L-RPLND provide safe and effective retroperitoneal lymph node dissection for testicular cancer. Patients with R-RPLND have less intraoperative bleeding, shorter hospitalization period, fewer postoperative complications, and faster recovery. It should be considered a viable alternative to O-RPLND/L-RPLND.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO, identifier CRD42023411696.
Cost-effectiveness analysis of elacestrant versus standard endocrine therapy for second-/third-line treatment of patients with HR+/HER2- advanced or metastatic breast cancer: a US payer perspective
Authors: Zeng Wanxian , Cao Xueqiong , Lin Jingwen , Zheng Bin , Li Na , Liu Maobai , Cai Hongfu
Published: December 2023

Background

This study evaluated the cost-effectiveness of elacestrant (ELA) and standard-of-care (SOC) as second-/third-line treatment for pretreated estrogen receptor (ER)– positive/human epidermal growth factor receptor 2 (HER2)–negative advanced or metastatic breast cancer (A/MBC) in the US.

Methods

The 3 health states partitioned survival model (PSM) was conducted from the perspective of the US third-party payers. The time horizon for the model lasted 10 years. Effectiveness and safety data were derived from the EMERALD trial (NCT03778931). Costs were derived from the pricing files of Medicare and Medicaid Services, and utility values were derived from published studies. One-way sensitivity analysis as well as probabilistic sensitivity analysis were performed to observe model stability.

Result

ELA led to an incremental cost-effectiveness ratio (ICER) of $8,672,360/quality-adjusted life year (QALY) gained compared with SOC in the overall population and $2,900,560/QALY gained compared with fulvestrant (FUL) in the ESR1(estrogen receptor 1) mutation subgroup. The two ICERs of ELA were significantly higher than the willingness-to-pay (WTP) threshold values of $150,000/QALY.

Conclusions

ELA was not cost-effective for the second-/third-line treatment of patients with ER+/HER2–A/MBC compared with SOC in the US.
Active components of Solanum nigrum and their antitumor effects: a literature review
Authors: Zhang Han , Lv Jun-lin , Zheng Qiu-sheng , Li Jie
Published: December 2023

Cancer poses a serious threat to human health and overall well-being. Conventional cancer treatments predominantly encompass surgical procedures and radiotherapy. Nevertheless, the substantial side effects and the emergence of drug resistance in patients significantly diminish their quality of life and overall prognosis. There is an acute need for innovative, efficient therapeutic agents to address these challenges. Plant-based herbal medicines and their derived compounds offer promising potential for cancer research and treatment due to their numerous advantages. Solanum nigrum (S. nigrum), a traditional Chinese medicine, finds extensive use in clinical settings. The steroidal compounds within S. nigrum, particularly steroidal alkaloids, exhibit robust antitumor properties either independently or when combined with other drugs. Many researchers have delved into unraveling the antitumor mechanisms of the active components present in S. nigrum, yielding notable progress. This literature review provides a comprehensive analysis of the research advancements concerning the active constituents of S. nigrum. Furthermore, it outlines the action mechanisms of select monomeric anticancer ingredients. Overall, the insights derived from this review offer a new perspective on the development of clinical anticancer drugs.
The regulation of inhibitor of apoptosis proteins (IAPs) during the apoptosis of Cotesia chilonis
Authors: Lu Ming-Xing , He Fu-Jing , Zhu Feng , Du Yu-Zhou
Published: December 2023

Inhibitor of apoptosis proteins (IAPs) are crucial components of apoptosis that perform vital roles in the regulation of caspase activity in organisms. In this study, two IAPs genes were identified from Cotesia chilonis, the dominant parasitic wasp of Chilo suppressalis. CcIAP1 gene is a typical IAP and contains two BIR domains and a RING domain, whereas CcIAP gene is an atypical IAP1 only containing two BIR domains. Phylogenetic analysis indicated that CcIAP1 and CcIAP were grouped with other Hymenopteran IAPs and IAP1 in C. suppressalis. Real-time quantitative PCR revealed that CcIAP1 and CcIAP genes were both highly induced at −6°C and 30°C, and expression was highest at the third instar stage. The expression of CcIAP1 and CcIAP genes were significantly induced during parasitism of C. suppressalis, and the 7-d time point resulted in the highest expression levels for both genes, in which was an advanced stage of larval development of C. chilonis. RNAi experiments showed that CcIAP1 gene was the key IAP in the regulation of apoptosis of C. chilonis and its host. In conclusion, CcIAP1 and CcIAP correlate with the development of C. chilonis and their responses to temperature stress.
Raffinose degradation-related gene GhAGAL3 was screened out responding to salinity stress through expression patterns of GhAGALs family genes
Authors: Chen Wenhua , Cui Yupeng , He Yunxin , Zhao Lanjie , Cui Ruifeng , Liu Xiaoyu , Huang Hui , Zhang Yuexin , Fan Yapeng , Feng Xixian , Ni Kesong , Jiang Tiantian , Han Mingge , Lei Yuqian , Liu Mengyue , Meng Yuan , Chen Xiugui , Lu Xuke , Wang Delong , Wang Junjuan , Wang Shuai , Guo Lixue , Chen Quanjia , Ye Wuwei
Published: December 2023

A-galactosidases (AGALs), the oligosaccharide (RFO) catabolic genes of the raffinose family, play crucial roles in plant growth and development and in adversity stress. They can break down the non-reducing terminal galactose residues of glycolipids and sugar chains. In this study, the whole genome of AGALs was analyzed. Bioinformatics analysis was conducted to analyze members of the AGAL family in Gossypium hirsutum, Gossypium arboreum, Gossypium barbadense, and Gossypium raimondii. Meanwhile, RT-qPCR was carried out to analyze the expression patterns of AGAL family members in different tissues of terrestrial cotton. It was found that a series of environmental factors stimulated the expression of the GhAGAL3 gene. The function of GhAGAL3 was verified through virus-induced gene silencing (VIGS). As a result, GhAGAL3 gene silencing resulted in milder wilting of seedlings than the controls, and a significant increase in the raffinose content in cotton, indicating that GhAGAL3 responded to NaCl stress. The increase in raffinose content improved the tolerance of cotton. Findings in this study lay an important foundation for further research on the role of the GhAGAL3 gene family in the molecular mechanism of abiotic stress resistance in cotton.
Enhanced wedelolactone content in in vitro-raised genetically uniform Wedelia chinensis under the influence of CuSO4
Authors: Swami Ravi Kant , Nimker Shwetanjali , Narula Alka , Farooqi Humaira
Published: December 2023

In the present study, we addressed the imperative for potent anticancer agents through Wedelia chinensis, a medicinal plant abundant in the robust antihepatotoxic and antitumor compound wedelolactone. Hindrances in conventional propagation methods due to cross-pollination and habitat degradation prompted us to pioneer in vitro rapid multiplication using plant tissue culture. Optimal outcomes were attained employing Murashige and Skoog (MS) medium supplemented with Indole-3-butyric acid (IBA) (0.5 mg/L) and Kinetin (KN) (5.0 mg/L), yielding 97.67% shoot regeneration and 81.67% rooting from nodal explants. Transplanted plantlets exhibited a 92% survival rate. We established a wedelolactone extraction protocol using toluene:ethyl acetate:formic acid (5:4:1) for High-performance thin-layer chromatography (HPTLC) analysis, trailblazing wedelolactone quantification and 2C DNA analysis in W. chinensis via flow cytometry. Experiments under heavy metal stress with CuSO4 unveiled physiological responses, with peak wedelolactone content [193.90 μg/g dry weight (dw)] in vitro at 75 μM CuSO4, surpassing in vivo levels (89.95 μg/g dw) by 116%. By pioneering successful in vitro rapid multiplication and enhanced wedelolactone content, we bridge a critical gap in the conservation and production of this medicinal plant. Our findings not only offer a sustainable means of propagation but also present a viable strategy for elevating the yield of potent bioactive molecules like wedelolactone, holding immense promise for the development of novel therapeutic interventions and addressing the pressing healthcare challenges of our time.
An appropriate ammonium: nitrate ratio promotes the growth of centipedegrass: insight from physiological and micromorphological analyses
Authors: Hao Dong-Li , Zhou Jin-Yan , Li Ling , Qu Jia , Li Xiao-Hui , Chen Rong-Rong , Kong Wei-Yi , Li Dan-Dan , Li Jian-Jian , Guo Hai-Lin , Liu Jian-Xiu , Zong Jun-Qin , Chen Jing-Bo
Published: December 2023

Reasonable nitrogen fertilizer application is an important strategy to maintain optimal growth of grasslands, thereby enabling them to better fulfil their ecological functions while reducing environmental pollution caused by high nitrogen fertilizer production and application. Optimizing the ammonium (NH4+):nitrate (NO3-) ratio is a common approach for growth promotion in crops and vegetables, but research on this topic in grass plants has not received sufficient attention. Centipedegrass, which is widely used in landscaping and ecological protection, was used as the experimental material. Different NH4+:NO3- ratios (0: 100, 25:75, 50:50, 75:25, 100:0) were used as the experimental treatments under hydroponic conditions. By monitoring the physiological and morphological changes under each treatment, the appropriate NH4+:NO3- ratio for growth and its underlying mechanism were determined. As the proportion of ammonium increased, the growth showed a “bell-shaped” response, with the maximum biomass and total carbon and nitrogen accumulation achieved with the NH4+:NO3- ratio of 50:50 treatment. Compared with the situation where nitrate was supplied alone, increasing the ammonium proportion increased the whole plant biomass by 93.2%, 139.7%, 59.0%, and 30.5%, the whole plant nitrogen accumulation by 44.9%, 94.6%, 32.8%, and 54.8%, and the whole plant carbon accumulation by 90.4%, 139.9%, 58.7%, and 26.6% in order. As a gateway for nitrogen input, the roots treated with an NH4+:NO3- ratio of 50:50 exhibited the highest ammonium and nitrate uptake rate, which may be related to the maximum total root length, root surface area, average root diameter, root volume, and largest root xylem vessel. As a gateway for carbon input, leaves treated with an NH4+:NO3- ratio of 50:50 exhibited the highest stomatal aperture, stomatal conductance, photosynthetic rate, transpiration rate, and photosynthetic products. The NH4+:NO3- ratio of 50:50 treatment had the largest stem xylem vessel area. This structure and force caused by transpiration may synergistically facilitate root-to-shoot nutrient translocation. Notably, the change in stomatal opening occurred in the early stage (4 hours) of the NH4+:NO3- ratio treatments, indicating that stomates are structures that are involved in the response to changes in the root NH4+:NO3- ratio. In summary, we recommend 50:50 as the appropriate NH4+:NO3- ratio for the growth of centipedegrass, which not only improves the nitrogen use efficiency but also enhances the carbon sequestration capacity.
Integrated metabolomic and transcriptomic analyses revealed metabolite variations and regulatory networks in Cinnamomum cassia Presl from four growth years
Authors: Gao Hongyang , Shi Min , Zhang Huiju , Shang Hongli , Yang Quan
Published: December 2023

To understand the mechanism of the dynamic accumulation of active ingredients in Cinnamomum cassia Presl, metabolomic and transcriptomic analyses of 5~8 years old C. cassia were performed. A total of 72 phenylpropanoids, 146 flavonoids, and 130 terpenoids showed marked changes. Most phenylpropanoids and flavonoids showed markedly higher abundances in 6-year-old C. cassia than in others, which was related to the higher expression of genes that synthesize and regulate phenylpropanoids and flavonoid. We identified transcription factors (TFs) and genes involved in phenylpropanoids and flavonoids synthesis and regulation through co-expression network analyses. Furthermore, most of the terpenoids in 5-year-old C. cassia showed markedly higher abundances than in others, which was due to the differentially expressed genes upstream of the terpenoids pathway. The results of our study provide new insights into the synthesis and accumulation of phenylpropanoid, flavonoids and terpenoids in C. cassia at four growth stages.
Deciphering the maritime diplomatic properties of Malaysia's oil and gas explorations in the South China Sea
Authors: Putra Bama Andika
Published: December 2023

Studies in maritime diplomacy have treated the development of oil and gas explorations in the South China Sea as taken-for-granted events. On the contrary, this study argues that assessing the maritime diplomatic properties inherent in energy reserve explorations can reveal unique insights, motivations, and significance of maritime diplomatic events. It assesses Malaysia's oil and gas explorations in the Luconia Shoals, informed by the analytical framework of Le Mière's maritime diplomatic properties. Utilizing secondary data from the Asian Maritime Transparency Initiative between 2020 and 2023 related to Malaysia's oil and gas project developments in the Luconia Shoals, this article concludes that the maritime diplomatic events consist of the following characteristics: (1) pre-emptive and sustainment, underlining Malaysia's long-term plan of fulfilling the growing domestic energy demand, (2) explicitness of the messages transmitted to Chinese officials in order to repel any possibilities of adversaries misconstruing Malaysia's actions at sea, and (3) moderate kinetic effect due to the lethal weaponry at the disposal of the hard power assets deployed to handle occurring crisis. Evaluation of Malaysia's maritime diplomatic properties also reveals two worrying conclusions: (1) the existence of reactive events, which can cause disruptions at sea due to the lack of planning related to the actions taken by the Royal Malaysian Navy, and (2) asymmetrical power relations between China and Malaysia, predicted to cause China to continue its power projections at sea and aggravate Malaysian policymakers.
Pretend play as the space for development of self-regulation: cultural-historical perspective
Authors: Bredikyte Milda , Brandisauskiene Agne
Published: December 2023

Self-regulated behavior is a prerequisite for learning and success in life. Considerable research confirms that mature forms of play support the development of self-regulation in the early years. This study explores the relationship between (3–6-year-olds) children’s pretend play and self-regulation skills. Teachers filled out a child’s play and self-regulation checklist evaluating the level of children’s play and self-regulation skills. The findings revealed that the levels of children’s play and self-regulation skills are statistically significantly linked: the better the child performs an assumed role in play activity, the higher the level of their self-regulation. The results also suggest that a child’s playing skills, gender, and age predict children’s self-regulation skills manifested in play activity.
Exploring the restorative benefits of work in smart working structures on vacations in small villages
Authors: Maffei Luigi , Ciervo Antonio , Marzocchi Raffaella , Masullo Massimiliano
Published: December 2023

Introduction

Processes of redefinition of work, already in place in the pre-pandemic era, with the advent of COVID-19, have become widely required. A “model of work” that uses new technologies and the development of existing ones to improve workers’ performance and satisfaction has emerged. Smart working has changed how people work and, as a result, spaces must also change to support them. The use of prefabricated movable buildings (PMB) could represent an opportunity to create smart (and co-) working spaces in a regenerative contest. Small villages with historical, architectural, and naturalistic elements and slow-life features are potential platforms where vacation and work could merge easily. This paper aims to establish if working in movable offices, like the PMBs, which provide a high level of visual and acoustics interaction with the surroundings, and which is positioned in small villages’ squares, can affect workers’ sense of restoration and working performance.

Methods

In a laboratory setting, in the SENS i-Lab, a videowall and a 3D spatial audio system were used to compare, in terms of restorativeness and self-reported cognitive performance, the effects of a high-rise building context of a City Business District (CBD), i.e. the control scenario, and of two typical squares of small Italian villages with historic buildings, without (HIS) and with water elements (HIS-W).

Results

The findings of the experimental sessions showed that when working in close contact (visual and auditory) with historical or water elements, where life flows slowly, workers perceived a higher sense of restoration while job performance was unchanged.

Discussion

Implementing smart working policies in small villages that encourage the use of energy-efficient prefabricated movable buildings and that offer a high level of visual and acoustic interaction with the surrounding environment may represent a promising strategy to foster the development of the local economy and contrast the depopulation of small villages, improving the worker well-being and the reducing the impact of their activities of the environment.
SEM analysis of agreement with regulating online hate speech: influences of victimization, social harm assessment, and regulatory effectiveness assessment
Authors: Park Ahran , Kim Minjeong , Kim Ee-Sun
Published: December 2023

In an era where digital interactions are increasingly prevalent, the challenge of effectively regulating online hate speech has emerged as a crucial societal concern. Balancing the regulation of such speech with the preservation of online freedom of expression is a delicate task, requiring broad consensus among internet users. This study delves into the various factors shaping public attitudes towards the regulation of online hate speech in South Korea. An online survey of 1,000 Internet users provided the data for a structural equation model. Our findings reveal that experiences of victimization by hate speech, online activity such as content uploading, assessment of social harm caused by online hate speech, and assessment on the effectiveness of regulatory measures all play significant roles in garnering support for regulation. Notably, online activity correlates strongly with increased encounters with hate speech. This, in turn, leads to a more profound understanding of its social harm and, consequently, a heightened inclination to support regulatory measures. These insights underscore the growing urgency to address online hate speech, especially as online activity continue to intensify. This study contributes to the discourse on online hate speech regulation by highlighting the complex interplay of personal experience, perceived harm, and efficacy of regulation in shaping public consensus.
Empirical approach to the gender gap in students’ reading consumption in international contexts
Authors: Trigo Ibáñez Ester , Santos Díaz Inmaculada Clotilde
Published: December 2023

Reading is a very important aspect today, which is why it is a recurring topic in research. This study aims to analyze the gender gap in the reading consumption of adolescents and compare the situation in Spain with that of other countries. It addresses, for the first time, the influence of the gender factor on the reading habits of adolescents who have just begun secondary education. This is an empirical study carried out based on the research projects “Determining factors in the reading habits of secondary education students. A study from the variables of the educational context” and “Reading habits in international contexts of Secondary Education students. A study of educational practices to promote reading.” It is based on the hypothesis that reading consumption is conditioned by gender and country-specific educational policies and, therefore, by the place where the study is carried out. To do this, an international sample of students was taken as a reference, made up of a matrix group of Spanish students contrasted with small samples from three different countries that we are interested in comparing with the Spanish context: Portugal, Poland, and Chile. The results have shown that the gender gap in reading is perceived in all the contexts studied and that it increases in contexts with less developed co-education programs; therefore, it is necessary to implement effective policies in the educational field to eliminate the existence of gender stereotypes.
Teaching higher education staff to understand and support autistic students: evaluation of a novel training program
Authors: Jenks Emma , Selman Freya , Harmens Miriam , Boon Sarah , Tran Trang , Hobson Hannah , Eagle Sarah , Sedgewick Felicity
Published: December 2023

Background

Autistic students are particularly vulnerable to stressors within a university environment and are more likely to experience poor mental health than their non-autistic peers. Students’ experiences of stigma from staff and peers, and the masking behaviors they deploy to minimize it, can also result in worsening mental health. Despite these concerns, there is a lack of tailored support for autistic students at university. The current project assesses a co-created training course for university staff focused on debunking stereotypes, educating about the autistic experience at university, mental health presentation among autistic individuals, and practical strategies to improve interactions with autistic students.

Methods

The Autism Stigma and Knowledge Questionnaire [ASK-Q] was administered before and after the training, to examine changes in trainees’ understanding and acceptance of autism and autistic people. Post-training interviews and surveys were also conducted with trainees, covering the impact the training has had on their perceptions of autism, the strategies they found beneficial, and how they will use the materials in future.

Results

There were no statistically significant differences between pre- and post-training scores on the ASK-Q, likely due to ceiling effects as pre-training scores were high. Thematic analysis of interviews identified five themes: value of lived experience; developing nuanced, in-depth knowledge of autism; training as acceptable and feasible; links to professional practice; and systemic barriers.

Conclusion

Although ceiling effects meant there were no changes to participant’s knowledge about autism and autistic people statistically, the qualitative data reveals the extensive benefits they gained from taking part in the training programs. Scoring highly on the ASK-Q did not mean that people could not learn important new information and benefit from the course. This more nuanced understanding of autism led to practical changes in their practice. Listening to and learning from autistic people was seen as particularly important, highlighting the value of co-production. Our results also emphasize the need for varied approaches to evaluating training effectiveness, as reliance on quantitative data alone would have missed the subtler, but impactful, changes our participants experienced. This has important implications for professional practice, both within higher education and more broadly.
Case report: Long-term management of occlusion after surgical-orthodontic treatment for a patient with drug-induced open bite developed after the onset of schizophrenia
Authors: Takada Jun-Ichi , Higashihori Norihisa , Kadota-Watanabe Chiho , Kawamoto Tatsuo , Toyofuku Akira , Moriyama Keiji
Published: December 2023

Background

Schizophrenia is a major mental disorder, with an estimated incidence of 1%. Since they are sensitive to sensory changes, orthodontic treatment to move teeth should be avoided as aggressively as possible in these patients because of strong concerns about the possibility of causing adverse psychological effects, thus there are few reports on orthodontic treatment for schizophrenia patients. We report a case of severe open bite caused by medication after the onset of schizophrenia, even though the patient’s occlusion had been stable for a long time after surgical orthodontic treatment. Medication control and the use of a minimally invasive orthodontic appliance improved the occlusion without adversely affecting the patient’s mental health.

Case

A 22-year-old woman presented to the clinic with a chief complaint of an anterior open bite. Intraoral findings showed an overbite (vertical overlap of the incisor teeth) of −3.0 mm and an overjet (horizontal overlap of the incisor teeth) of −0.5 mm. The preoperative orthodontic treatment included bilateral extraction of the maxillary first premolars. Subsequently, orthognathic surgery was performed to achieve a harmonized skeletal relationship and occlusion. Occlusion was stable for 3 years after surgery. However, 10 years after surgery, the patient returned to the clinic complaining of an anterior open bite (overbite = −4.0 mm). Six years prior to the return, the patient was diagnosed with schizophrenia. We thought that ignoring the patient’s strong desire to treat her open bite might also cause psychological problems; therefore, in addition to medication control, we treated her using a minimally invasive removable orthodontic appliance (retainer with tongue crib). Her anterior open bite improved (overbite, +1.0 mm) to within the normal range.

Conclusion

In this case, medication control was thought to be essential to improve her drug-induced open bite. However, minimally invasive orthodontic treatment, such as the use of a removable appliance, might be helpful in promoting her mental stability as well as for improving occlusion. Careful support is required to obtain information about the patient’s mental state and medications through close cooperation with psychiatrists.
Resilience, organizational support, and innovative behavior on nurses’ work engagement: a moderated mediation analysis
Authors: Zhou Feiyang , Long Keyu , Shen Haiyan , Yang Zixuan , Yang Tingting , Deng Lu , Zhang Jie
Published: December 2023

Objectives

To investigate the status of nurses’ work engagement and the relationship among resilience, organizational support, and innovative behaviors.

Methods

In this cross-sectional study, we investigated 496 nurses in Hunan, China, from July 2022 to December 2022. A descriptive statistical approach, Pearson’s correlation analysis and Hayes’ PROCESS Macro Models 4 and 14 were used to analyze the available data.

Results

The level of work engagement among nurses was found to be moderate. Resilience positively predicted work engagement among nurses. Organizational support played a partially mediating role in the association between resilience and work engagement. Furthermore, innovative behavior played a moderating role in the association between adaptive resilience and work engagement.

Conclusion

Based on the results, greater attention needs to be paid to nurses’ work engagement. A high level of resilience, organizational support, and innovative behavior may increase work engagement among nurses. Nursing leaders can take measures to increase work engagement among nurses by improving nurses’ resilience and organizational support, and cultivating innovative behavior.
Hydrogeochemical characteristics and evaluation of groundwater resources of Jilin Province, China
Authors: Zeng Zhaojun , Cui Yueju , Zhou Xiaocheng , Pan Xiaodong , Sun Fengxia , Liu Yinan , Tian Jiao , He Miao , Zhang Yongxian , Yan Yucong , Zou Zhenyu , Wang Yuwen , Yao Bingyu , Xing Gaoyuan , Cui Shihan
Published: December 2023

As one of China's nine border provinces, Jilin Province is an important window for China's “Belt and Road” to open up to the north, and an important channel for China's foreign trade and foreign exchanges. Therefore, understanding hydrogeochemical characteristics is very important for effective water resources management in Jilin Province. A total of 64 groundwater samples were collected from 32 monitoring Wells in Jilin Province. Use of hydrogeochemical analysis techniques, WQI index and human health risk index methods to assess hydrogeochemical processes and groundwater quality, including the determination of hydrogeochemical parameters, conventional ions, trace elements and stable isotopes (δD and δ18O). The results show that the groundwater is slightly alkaline, the cations are mainly Na+, Ca2+, Mg2+, and K+, and the anions are mainly HCO3-, Cl−, and SO42-. Most of the groundwater samples belong to Ca-HCO3 and Na-HCO3 types, which are formed by the dissolution of calcite, dolomite, gypsum, silicates and carbonates. Stable isotope analysis shows that groundwater recharge in Jilin mainly comes from atmospheric precipitation at an altitude of 1,430~2,348 m. The strong correlation between trace elements indicates a common source. Most of the groundwater quality index (WQI) in the study area is Class I to Class III, and hazard quotient (HQ) and hazard index (HI) are both below 1. This indicates excellent water quality and minimal health risks associated with human consumption. It is worth noting that trace elements are enriched in the Tanlu fault zone. It provides scientific guidance for the utilization and allocation of groundwater resources in Jilin Province.
Why Some Couples Cannot Have Children
Authors: Amaral Sandra , Escada-Rebelo Sara , Cristo Maria I. , Ramalho-Santos João , Amaral Sara Varela , Silva Andreia F.
Published: December 2023

While many of the organs in our bodies are similar in men and women, the reproductive organs differ. The male and female sex cells, called gametes, differ too: sperm in the male and oocytes in the female. Male and female gametes must come together to make a baby. This amazing capacity to create a new life is called reproduction. The process of reproduction is quite complicated, and sometimes things can go wrong, preventing a couple from having a child—a condition called infertility. In this article, we explain how the reproductive cells normally meet and some of the problems that can happen along the way, resulting in infertility. We will also explain how some causes of infertility are treatable and we will describe several medical techniques that have been developed to help infertile couples to have babies.
Understanding farmers’ intentions to participate in traceability systems: evidence from SEM-ANN-NCA
Authors: Huang Yatao , Fu Shaoling
Published: December 2023

Introduction

As a crucial technological tool for ensuring the quality and safety of agricultural products, the traceability system is of great importance in the agricultural sector. However, farmers’ participation in the system, especially among small-scale farmers, remains relatively low.

Methods

This study investigates the factors that influence farmers’ intentions to participate in traceability systems by integrating moral norms and policy support into the technology acceptance model (TAM) and using a three-stage approach of structural equation modeling (SEM), artificial neural network (ANN), and necessary condition analysis (NCA).

Results

The findings indicated that farmers’ intentions were primarily influenced by perceived usefulness. Perceived usefulness and perceived ease of use were strongly affected by moral norms and policy support. To promote farmers’ intentions, it is necessary to achieve at least 75, 66.7, 45.5, and 50% of perceived usefulness, perceived ease of use, moral norms, and policy support, respectively.

Discussion

These findings provide valuable guidance to government agencies and technology developers in prioritizing adoption strategies. This study not only expands the scope of TAM research, but also represents an early application of a three-stage approach to agricultural technology adoption research.
Postnatal development of salivary phosphate, sodium and potassium secretion in calves
Authors: Muscher-Banse Alexandra S. , Daenicke Reinhard , Dänicke Sven , Breves Gerhard
Published: December 2023

The transition of young lambs and calves from a non-ruminating to a ruminating animal include substantial, developmental changes to alter saliva production. Due to the simultaneous development of the forestomach system, the salivary glands must transfer more and more substances such as bicarbonate and phosphate (Pi), but also sodium (Na), into saliva in order to create and to maintain optimal environmental conditions for microbial metabolism. The objective of the present study was to characterize the effects of different dietary energy levels on the ability of the salivary glands to concentrate minerals in young ruminants in more detail during the first 7 weeks of life. Blood and saliva samples were collected from twelve female calves of the German Holstein breed fed different levels of milk replacer. Plasma and saliva samples were collected over 7 weeks postpartum and Na, Pi and potassium (K) concentrations were measured. Salivary Na and Pi concentrations (p< 0.001) increased as a function of time and were not affected by varying energy intake, while K concentration (p< 0.001) decreased over the developmental period and was also not affected by energy intake. This suggests that the ability to specifically concentrate minerals such as Na and Pi in saliva follows a genetic program in the salivary glands rather than being influenced by dietary factors such as energy intake in young ruminants.
Phenotypic characterization of Pomeranians with or without Chiari-like malformation and syringomyelia
Authors: Santifort Koen M. , Carrera Ines , Bossens Kenny , Mandigers Paul J. J.
Published: December 2023

Introduction

Chiari-like malformation (CM) and syringomyelia (SM) are frequently diagnosed conditions in small and toy dog breeds, such as the Cavalier King Charles Spaniel and Griffon Bruxellois. CM/SM is only rarely reported in Pomeranians in literature to date. The aims of this study are to 1/describe the phenotype of Pomeranians with or without CM/SM and 2/evaluate for differences and associations between CM/SM and owner-reported clinical signs (ORCS) or signalment factors.

Materials and methods

From February 2015 to June 2023, historical data and signalment (including country of origin, pedigree, sex and neuter status, age, and body weight) and ORCS of Pomeranians were recorded at multiple institutions. MRI studies of all dogs were evaluated for classification of CM/SM. Additionally, quantitative measurements were performed for SM.

Results

A total of 796 dogs from 22 different countries were included. Total prevalence of CM was 54.9% (437/796) and the prevalence of SM was 23.9% (190/796). The top 5 ORCS included 1/scratching with skin contact, rubbing head or ears, or both (57.6% of dogs with ORCS), 2/air licking (30.7% of dogs with ORCS), 3/spontaneous signs of pain (26.0% of dogs with ORCS), 4/persistent licking front and/or hind paws (22.6% of dogs with ORCS), 5/phantom scratching (22.6% of dogs with ORCS). Phantom scratching, vocalization, head shaking, spontaneous signs of pain, and air licking were associated with having SM. There were no statistically significant associations between quantitative syrinx measurements and ORCS. There were statistically significant associations between CM classification and 1/country of origin, 2/having a pedigree, and 3/age. There were statistically significant associations between SM classification and 1/age and 2/body weight.

Discussion

This is the first large study evaluating CM/SM in the Pomeranian dog breed. Veterinary clinicians can use these findings to increase the likelihood of correctly determining the presence or absence of CM/SM in Pomeranians. Breeders may consider using the information regarding signalment factors as well as ORCS associated with CM/SM classifications to select dogs for screening procedures. But an MRI-based diagnosis is needed to properly ascertain the exact CM/SM status of their breeding stock until a fool-proof characteristic or genetic marker is found.
The Dimensions of Entrepreneurial Orientation in Franchise Networks: Exploring the Role of Franchisee Associations
Authors: Balsarini Peter , Lambert Claire
Published: December 2023

This study explores how a state-based franchisee association of a multinational quick-service restaurant franchisor introduced three world-first innovations through the activation of the five dimensions of entrepreneurial orientation (EO). The antecedents to this activation were also explored. A historical extended case study focusing on a revelatory case was undertaken. In-depth analysis using a rigorous qualitative methodology was facilitated by the triangulation of informant interviews, publicly available data, archival data, and artefacts. The three innovations explored involved the apparent activation of all five dimensions of EO by the franchisee association. The franchisee association’s structure and the provenance of its franchisee members, in being either externally recruited or internally recruited, appeared to have a bearing on whether product or process innovations were pursued. Five antecedents that enhance the propensity of franchisee associations to activate the dimensions of EO were also identified, and a preliminary model was constructed. Whilst the EO of franchisors and franchisees has previously been examined, this study is the first to explore franchisee associations as a vehicle for EO. With around 75% of franchisors incorporating some form of franchisee association, better understanding how to harness their innovative potential could bestow a competitive advantage upon those franchise systems able to do so.
Physico-Chemical Analysis of the Fruits and Consumer Preferences of New Apple (Malus × domestica Borkh) Hybrids Bred in Poland
Authors: Szpadzik Ewa , Molska-Kawulok Karolina , Krupa Tomasz , Przybyłko Sebastian
Published: December 2023

Apples are the most important species in Polish fruit production, and their fresh fruit and processing products occupy a very important place in the European and world food economies. A natural process on the apple market is the replacement of older cultivars with new ones. Consequently, breeding work is being carried out all over the world to obtain new, attractive apple cultivars. In this work, four new apple hybrids obtained in the Department of Pomology and Horticulture Economics at the University of Life Sciences in Warsaw (WULS—SGGW), i.e., two red-skinned hybrids (‘I’P’ and ‘TL’) and two green-skinned hybrids (‘GL’ and ‘LG’), were tested for their main physico-chemical characteristics after harvest and after storage, as well as for their consumer acceptability in a comparison with three popular cultivars in Poland (‘Šampion’, ‘Golden Delicious’, and ‘Ligol’). The hybrids evaluated were differentiated in terms of the tested features. It was found that the fruits of the ‘GL’ hybrid had the highest firmness—both after harvest and post storage; it was also one of the highest-rated overall impressions by consumers among the cultivars tested (only ‘Ligol’ apples had higher scores). The hybrid with low fruit quality and low health-promoting properties at this stage of the study was ‘TL’, whose overall impression was also rated lowest by consumers. The study also showed that the content of bioactive compounds and antioxidant activity of apples can be higher in green-skinned cultivars compared to red-skinned cultivars.
Prediction of Stem Water Potential in Olive Orchards Using High-Resolution Planet Satellite Images and Machine Learning Techniques
Authors: Garofalo Simone Pietro , Giannico Vincenzo , Costanza Leonardo , Alhajj Ali Salem , Camposeo Salvatore , Lopriore Giuseppe , Pedrero Salcedo Francisco , Vivaldi Gaetano Alessandro
Published: December 2023

Assessing plant water status accurately in both time and space is crucial for maintaining satisfactory crop yield and quality standards, especially in the face of a changing climate. Remote sensing technology offers a promising alternative to traditional in situ measurements for estimating stem water potential (Ψstem). In this study, we carried out field measurements of Ψstem in an irrigated olive orchard in southern Italy during the 2021 and 2022 seasons. Water status data were acquired at midday from 24 olive trees between June and October in both years. Reflectance data collected at the time of Ψstem measurements were utilized to calculate vegetation indices (VIs). Employing machine learning techniques, various prediction models were developed by considering VIs and spectral bands as predictors. Before the analyses, both datasets were randomly split into training and testing datasets. Our findings reveal that the random forest model outperformed other models, providing a more accurate prediction of olive water status (R2 = 0.78). This is the first study in the literature integrating remote sensing and machine learning techniques for the prediction of olive water status in order to improve olive orchard irrigation management, offering a practical solution for estimating Ψstem avoiding time-consuming and resource-intensive fieldwork.