bluuebunny/crossref_metadata_2025 huggingface dataset:
SENSORIMOTOR ALTERATIONS AND ASSOCIATED FACTORS IN DIABETES MELLITUS PATIENTS
Authors: Brito Jéssyca Fernanda Pereira , Oliveira Aline Costa de , Sousa Luana Silva de , Silva Erlane Brito da , Rocha Elyrose Sousa Brito , Bezerra Sandra Marina Gonçalves
Published: April 2020

ABSTRACT Objective: to evaluate sensorimotor alterations in the extremities of the lower limbs and associated factors in Diabetes Mellitus patients. Method: this was a cross-sectional and analytical study, conducted in a Basic Health Unit, in Teresina (Brazil) with a sample of 102 participants between April and July 2018, by means of a semi-structured form. For the statistical analyses, the Pearson's chi-square and Fisher's exact tests were performed. Results: among the study participants, 99 (97.1%) presented alterations, 73 (71.6%) on the skin and 40 (39.2%) on nails. The sensorimotor examination identified 40 (39.22%) individuals with tactile sensitivity alterations and 13 (12.7%) with reduced vibratory sensitivity, using the 128 Hz tuning fork. The factors associated with sensorimotor alterations detected by the 10 gram monofilament were the following: time of disease over ten years; absence of periodic foot evaluation (p=0.003); impaired visual acuity (p=0.001); presence of pain or discomfort (p=0.003); pain worsening at night (p=0.008); moderate pain intensity (p=0.012) and relief at rest (p=0.015). Conclusion: sensory alterations in the lower limbs showed their relationship with some of the research variables, such as time of disease, foot evaluation, glycemic value, presence of pain or discomfort (worsening and relief shifts, and intensity), skin coloring and vibratory sensitivity evaluation with a tuning fork.
Debriefing methods and techniques used in nursing simulation
Authors: Nascimento Juliana da Silva Garcia , Oliveira Jordana Luiza Gouvêa de , Alves Mateus Goulart , Braga Fernanda Titareli Merizio Martins , Góes Fernanda dos Santos Nogueira de , Dalri Maria Celia Barcellos
Published: April 2020

ABSTRACT Objective: To identify in the literature methods and techniques of debriefing used in teaching and learning in nursing simulation. Methods: Integrative review of PubMed/MEDLINE®, LILACS, Scopus and CINAHL® databases, with the descriptors "nursing", "nursing education", respective terms in English and Spanish, and the keyword "debriefing". Twelve primary studies, in Portuguese, English and Spanish, from January 2008 to December 2018 were included. Qualitative analysis was used to categorize the domains. Results: The identified meaningful learning methods were based on principles of transfer of learning; model of clinical reasoning, interprofessional, with good judgment and structured and self-debriefing techniques, oral, eye-tracking, video-assisted and written debriefing. Conclusions: The structured method and the oral technique with video were outstanding. One method was not superior to the other but effective for a particular proposal. No national studies have been found. Research should be conducted on the effectiveness of nursing debriefing methods and techniques.
BRAZILIAN SOCIETY OF HEPATOLOGY UPDATED RECOMMENDATIONS FOR DIAGNOSIS AND TREATMENT OF HEPATOCELLULAR CARCINOMA
Authors: CHAGAS Aline Lopes , MATTOS Angelo Alves de , CARRILHO Flair José , BITTENCOURT Paulo Lisboa , VEZOZZO Denise Cerqueira Paranaguá , HORVAT Natally , ROCHA Manoel de Souza , ALVES Venâncio Avancini Ferreira , CORAL Gabriela Perdomo , ALVARES-DA-SILVA Mario Reis , BARROS Fabio Marinho do Rego , MENEZES Marcos Roberto , MONSIGNORE Lucas Moretti , COELHO Fabricio Ferreira , SILVA Renato Ferreira da , SILVA Rita de Cássia Martins Alves , BOIN Ilka de Fatima Santana Ferreira , D`ALBUQUERQUE Luiz Augusto Carneiro , GARCIA José Huygens Parente , FELGA Guilherme Eduardo Gonçalves , MOREIRA Airton Mota , BRAGHIROLI Maria Ignez Freitas Melro , HOFF Paulo Marcelo Gehm , MELLO Vivianne Barretto de , DOTTORI Mariana Fonseca , BRANCO Tiago Pugliese , SCHIAVON Leonardo de Lucca , COSTA Thaisa de Fátima Almeida
Published: April 2020

ABSTRACT Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The Brazilian Society of Hepatology (SBH) published in 2015 its first recommendations about the management of HCC. Since then, new data have emerged in the literature, prompting the governing board of SBH to sponsor a single-topic meeting in August 2018 in São Paulo. All the invited experts were asked to make a systematic review of the literature reviewing the management of HCC in subjects with cirrhosis. After the meeting, all panelists gathered together for the discussion of the topics and the elaboration of updated recommendations. The text was subsequently submitted for suggestions and approval of all members of the Brazilian Society of Hepatology through its homepage. The present manuscript is the final version of the reviewed manuscript containing the recommendations of SBH.
Endoparasites of household and shelter cats in the city of Rio de Janeiro, Brazil
Authors: Ramos Nilcéia de Veiga , Silva Monique Lourenço e , Barreto Marília Senra , Barros Luciano Antunes , Mendes-de-Almeida Flavya
Published: April 2020

Abstract Endoparasitic infections are associated with morbidity in cats. This study aimed to investigate the occurrence of endoparasites among cats of different life stages in the city of Rio de Janeiro, Brazil. The samples were analyzed individually by macroscopic exploration for proglottids and centrifugal-flotation. Stool samples were obtained from household cats (n = 57) and shelter cats (n = 336). Endoparasites were detected in 50.64% of the samples. Among household and shelter cats, 21.05% and 55.66% were infected with endoparasites, respectively. In household cats, the most prevalent endoparasites were Ancylostoma spp. (in 25.0%) and Strongyloides spp. (in 25.0%), followed by Toxocara spp. (in 16.67%), Dipylidium caninum (in 16.67%), Cystoisospora spp. (in 8.33%), and Uncinaria spp. + Ancylostoma spp. (in 8.33%). In shelter cats, the most prevalent endoparasite was Ancylostoma spp. (in 29.41%), followed by Cystoisospora spp. (in 26.20%) and Toxocara spp. (in 16.58%), as well as Cystoisospora spp. + Toxocara spp. (in 8.02%); Ancylostoma spp. + Toxocara spp. (in 11.76%); Cystoisospora spp. + Ancylostoma spp. (in 3.74%); Cystoisospora spp. + Toxocara spp. + Ancylostoma spp. (in 3.21%); and Dipylidium caninum + Ancylostoma spp. (in 0.53%). Endoparasitic infections in cats underscore the need for preventive veterinary care and routine coproparasitologic tests.
A protocol for massively parallel diagnosis and genome sequencing of SARS-CoV-2 v1
Authors: G Monahan Leigh , Anantanawat Kay , To Joyce , Darling Aaron
Published: April 2020

Managing the current COVID-19 pandemic requires diagnostic testing at an unprecedented scale. However, the crisis has revealed severe deficiencies in our capacity to perform such testing. Here we build on the work of others (1-3) to develop a protocol that not only enables many thousand diagnostic tests to be run in parallel, but also provides near-whole genome sequencing data to facilitate phylogenetic analysis and contact tracing. One of the key features of our protocol is a magnetic bead-based strategy for RNA capture that may circumvent the need for SARS-CoV-2 RNA extraction, currently one of the major bottlenecks in both reagent supply and hands-on sample processing time. This approach also eliminates the requirement for per-sample reverse transcription, significantly reducing per-sample costs. The major steps in our wet lab workflow can be summarised as follows. First, we generate a collection of bead-bound, single-stranded DNA probes tiling the entire SARS-CoV-2 genome. Multiple uniquely barcoded probe sets are prepared, each of which are used to capture viral RNA directly from patient swab samples via DNA/RNA hybridisation. Samples are combined together at this stage, enabling cDNA synthesis to be performed in a single pooled reaction. Finally, multiplex PCR is used to generate a library of overlapping amplicons ready for Illumina sequencing. A schematic overview of the workflow is attached below, along with a more detailed figure depicting the various stages of library preparation. References https://docs.google.com/document/d/1kP2w_uTMSep2UxTCOnUhh1TMCjWvHEY0sUUpkJHPYV4/preview https://www.protocols.io/view/ncov-2019-sequencing-protocol-bbmuik6w/abstract https://www.biorxiv.org/content/10.1101/2020.03.20.001008v1.full.pdf
RNA Extraction and Complimentary DNA Synthesis v1
Authors: Lalonde Christine , Murray Alyssa , Khurana Sandhya , Tharmalingam Sujeenthar , Boreham Douglas , Tai T.C.
Published: April 2020

Extraction of RNA from neural sections and complimentary DNA synthesis. This technique has been replicated multiple times in our laboratory and produces high yield.
10% Triton X-100 v1
Authors: Institute for Brain Science Allen
Published: April 2020

This protocol is used to attain 10% Triton X-100 which is utilized in several Immunohistochemistry (IHC) reagents to reduce the surface tension of the reagents and to make the cell membranes of the tissue more permeable. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Complications caused by excessive hemostatic tamponade in the removed tumor area in transnasal endoscopic surgery of pituitary adenoma
Authors: Andreev D. N. , Kutin M. A. , Kalinin P. L. , Shkarubo A. N. , Kadashev B. A. , Fomichev D. V. , Sharipov O. I. , Tropinskaya O. F. , Astafieva L. I. , Sidneva Yu. G. , Voronina I. A. , Mikhailov N. I. , Abdilatipov A. A. , Chernov I. V.
Published: April 2020

The phenomena of the mass effect of hemostatic material in the removed tumor area without the presence of a hematoma that causes or worsens the patient’s neurological status after surgery are difficult to diagnose and, with untimely help, causes irreversible neurological disorders. In world literature, we have found isolated sources describing similar complications. In the article, we present 7 clinical cases recorded from 2005 to 2019 in N. N. Burdenko National Medical Research Center of Neurosurgery and own experience in solving these difficult problems.
Outcomes of neurosurgical treatment of patients with non-visualized adenoma and microadenoma of the pituitary gland and with Cushing’s disease
Authors: Ivashchenko O. V. , Grigoriev A. Yu. , Azizyan V. N. , Nadezhdina E. Yu. , Rebrova O. Yu. , Lapshina A. M. , Kolesnikova G. S.
Published: April 2020

The study objective is to compare pre- and intraoperative characteristics, and the results of neurosurgical treatment in patients with Cushing’s disease, non-visualized adenoma and microadenoma of the pituitary gland.

Materials and methods. The results of transsphenoidal adenomectomy were analyzed in 102 patients with non-visualized corticotropinomas and 360 patients with microcorticotropinomas. The pituitary genesis of endogenous ACTH-dependent hypercorticism in 182 patients was proved by the results of selective blood sampling from inferior petrosal sinus with stimulation desmopressin. The study included 369 women and 93 men aged 16 to 64 years. All patients were operated by transnasal approach using endoscopic techniques.

Results. The group with non-visualized adenoma was dominated by men (p = 0.005) and patients with severe hypercorticism (p = 0.021). When comparing intraoperative characteristics in this group, invasive growth was statistically significantly more frequent (53 % vs 39 %) (p = 0.017), which in turn led to more aggressive intraoperative tactics (p <0.001) and more frequent development of hypothyroidism (11 % vs 4 %) (p = 0.028) in the early postoperative period. Early postoperative remission occurred in 73 (72 %) of 102 patients with non-visualized adenoma and in 314 (87 %) of 360 patients with microadenoma (p <0.001).

Conclusion. Early results of primary transsphenoidal adenomectomy in patients with non-visualized pituitary adenoma were significantly worse in comparison with patients with microadenoma detected by 1.5 T magnetic resonance imaging, which have more frequently invasive growth, what leads to an increase in the volume of surgery and a possible increase in postoperative hypopituitarism.
Grammatical distractors in CLIL-oriented tests on international legal english
Authors: Milovidova A. I.
Published: April 2020

The article addresses the use of grammatical distractors in planning, preparation and a conducting process of tests in legal English, and the analysis of their results. It also considers their potential for consolidating the most important skills of professional communication of future specialists. The formative nature of distractors finds its application in a number of specific tasks that contribute to the achievement of these important aims. Such aims include: maintaining of a positive attitude towards learning a foreign language, the ability to self-control during the act of speaking, increasing the level of motivation and educational autonomy. They also undermine the development of teamwork skills and its organization with minimal assistance, as well as the correct understanding of the role of the grammatical aspect in learning and the high value of grammatical correctness of speech, regardless of the degree of an individual’s fluency. Attempts have been made to classify grammatical distractors for learning convenience in the study room.
Linguistic representation of the English legal system in modern media
Authors: Nizovets T. I.
Published: April 2020

The article deals with the image of the English justice system in online versions of English newspapers, magazines and radio talk shows. On the basis of the analysis of different types of word combinations used in the description of lawyers, judges, courts and everyday legal practices there have been revealed some positive and negative characteristics of the system. The effect of the recent cuts to legal aid on the functioning of the legal system is discussed. Conclusions are made about the state of British society today and links between law and politics. Ways of incorporating this knowledge in the English language classroom are outlined.
Study of law through language approach as adopted in teaching international lawyers at MGIMO-University
Authors: Tolstopyatenko G. P. , Fedotova I. G. , Bogdanova I. A.
Published: April 2020

The article focuses on teaching English to international lawyers. The authors describe the approach developed and adopted in teaching legal English to international lawyers at MGIMO-University. Within the framework of this approach linguistics and jurisprudence become equivalent and equal factors in building a concise picture of the target subject — the system of the legal concepts and legal terminology of a foreign language. In the opinion of the authors this should be viewed as an important didactic goal of international lawyer training, i.e. training a professional who is not only able to fluently use foreign terminology, but, having thoroughly understood the respective extra lingual realia, contribute to a true dialogue of cultures vital to modern social interaction.
English language and the law – opportunities in the University
Authors: Goddard Ch.
Published: April 2020

This short article gives the reader an insight into some of the methods used at our university to support students who wish to become more proficient in Legal English. It begins with an overview of its importance to the student, and provides some details of courses, their contents and other opportunities which are available free of charge to assist the acquisition of a major skill for the modern lawyer.
Use of project method in learning the professional english language by law students
Authors: Ezhova N. F.
Published: April 2020

This article is devoted to the problem of learning a foreign language in a non-linguistic University. It is relevant and important to search innovative methods of teaching English to law students in the context of the implementation of FSES (3++) . The project method is considered to be effective.
The implementation of contemporary progressive teaching methods in teaching foreign languages in the framework of additional education
Authors: Yashina O. V.
Published: April 2020

The article deals with the problems of educational technologies, contemporary progressive teaching methods used for professional language teaching. The use of these technologies in the framework of additional language education. Special attention is given to learning language for specific purposes and different additional language programs that provide professional language training.
Immunity of foreign state in french practice
Authors: Guyot D.
Published: April 2020

The article contains analyses of the immunity of foreign states in the context of French legal practice. There are also cases of adoption of new legal norms to strengthen the state immunity of France.
EU Ethical Charter on the Use of Artificial Intelligence in Judicial Systems with a part of the law being established on Blockchain as a trojan horse anti-counterfeiting in a Global perspective
Authors: Antinucci M.
Published: April 2020

In 2018 the use of artificial intelligence (AI) algorithms in European judicial systems remains primarily a private-sector commercial initiative aimed at insurance companies, legal departments, lawyers and individuals. The European Commission for the Eﬃciency of Justice (CEPEJ) of the Council of Europe in the 4 of the december 2018 has adopted the first european text setting out ethical principles relating to the use of artificial intelligence (AI) in judicial systems. The Charter provides a framework of principles that can guide policy makers, legislators and justice professionals when they grapple with the rapid development of AI in national judicial processes. Aside from the benefits for copyright traceability and management, blockchain can also become a central means for protecting digital assets and provide the rightholder with the ability to pursue civil and criminal remedies. The Anti-Counterfeiting Blokathon Forum on 2018 takes forward its works on using blockchain to cocreate the future EU anti-counterfeiting infrastructure. Could blockchain live up to the challenge? Any future anti-counterfeiting blockchain solution must comply with Regulation (EU) No 608/2013 of the European Parliament and of the Council of 12 June 2013 concerning customs enforcement of intellectual property rights, and with Ethical Charter made from CEPEJ in the 2018.
Problems of relationship and legal regulation of cryptocurrency, bitcoin, digital and virtual currency: russian and foreign experience
Authors: Egorova M. A.
Published: April 2020

Crypto currency, bitcoins and virtual currencies are topics the scientific community has been discussing for years. The Bank of the Russia has repeatedly warned about high risks of investments in crypto currencies and risks in its turnover. Populations of many countries continue to lose their investments in virtual currencies, which are positioned by their developers as tamper-proof. However, there is still a vacuum in the legal regulation of crypto currencies and the legitimacy of their use as legal payment. The article presents the author’s view on a number of issues arisen in the process of crypto currency, bitcoin, digital and virtual currency use and presents ways to solve them in the context of Russian and world experience.
The importance of patents in international commerce — a practical guide
Authors: Shillinglaw T.
Published: April 2020

The article focuses on the study of the protection of more valuable corporate assets. It presents the most appropriate ways to provide such protection, to create a well-organized and eﬀectively implemented program of project development.
The new attraction of french law for international trade
Authors: Duflot A.
Published: April 2020

The article considers new apects of attraction of french law for international trade in terms of its impact on economic and political spheres, in particular, the issues arising from intense competition in the market. There are also cases where French law in international trade has some influence in our time.
Current issues in the state-owned companies in federation of Bosnia and Herzegovina
Authors: Grbo Z.
Published: April 2020

This article covers the peculiarities of the legal status of state and public companies. Similarities and diﬀerences between these types on the part of government participation in their management. Also, it provides survey of the similarities and diﬀerences between these types from the state involvement in their management.
Integration of social and environmental responsibility into legal concepts: the problems of applying the French Law of 2017 «On the duty of due diligence»
Authors: Rosa F.
Published: April 2020

The article examines the integration of social and environmental responsibility into legal concepts, in particular, issues arising from the problem of the application of the French law of 2017 “On the duty of due diligence”.
To the question about the possibility of patenting human genes: experience of legal regulation in Russia and France
Authors: Ponomareva D. V.
Published: April 2020

The article considers the problem of patenting human genes, encouraging the development of scientific inventions in the commercial field, the increase of investment attractiveness of research. It provides cases of these problems and the main approaches to solving them from the legal point of view.
Ethical aspects and personal data protection in the execution of home prison penalty
Authors: Michalov L. , Treshchakova D.
Published: April 2020

The home prison penalty is currently a part of the sanction system in the Slovak Republic and serves as a manifestation of so-called restorative justice. Restorative justice is represented by alternative sentences that are distinguished from real imprisonment for minor oﬀences. Alternative penalties may include penalties that do not involve the deprivation of liberty associated with the isolation of a convicted person. The advantage of alternative sentences is that the oﬀender is spared the destructive eﬀects of imprisonment. The oﬀender is not exposed to the negative aspects of this punishment and remains integrated into the society, being able to continue to maintain social, family and working relations, which can significantly improve the protection from the oﬀender.

At present, there are many unresolved issues regarding the execution of the punishment of home prison penalty, especially its execution through electronic monitoring, including the protection of personal data obtained through electronic monitoring equipment. Thus, the purpose of this article is to focus on these issues and present the authors’ views.
Prevention of self-harm and suicide in adolescents
Authors: Istriana Erita
Published: April 2020

Adolescence is a transitional stage in physical and psychological development, and in this stage multiple physical, emotional and social changes, can make adolescents vulnerable to mental health problems like self-harm and suicide. Self-harm and suicide are serious problems in children, adolescents and young people with the highest rates seen in those aged 16-24 years, and self-harm is highly correlated with the presence of anxiety disorders and depression.
Glycated albumin is a better indicator for glucose levels than glycated hemoglobin in patients with diabetes mellitus on insulin therapy
Authors: Lesmana Alvina , Pusparini Pusparini , Meiyanti Meiyanti , Merijanti Lie T
Published: April 2020

BackgroundDiabetes mellitus (DM) is a metabolic disease with a large incidence in the world and constitutes a global health problem. By 2030 it is estimated that there will be around 439 million people suffering from DM. Diabetes mellitus is a metabolic disease caused by a lack or absence of the hormone insulin. In type 2 DM pharmacotherapy can be given one of which is insulin. To monitor therapy, random blood glucose, glycated hemoglobin (HbA1c) and glycated albumin (GA) levels can be examined. The objective of this study was to determine the relationship of glycated albumin and glycated hemoglobin (HbA1c) with random blood glucose in insulin-treated diabetics.MethodsA cross-sectional study was conducted involving 92 type 2 diabetic patients treated with insulin. The study used a questionnaire and blood samples. We measured the GA , HbA1C and random blood glucose levels. A multiple linear regression was used to analyze the data. ResultsMean HbA1c was 9.21 ± 2.15%, mean glycated albumin was 24.4 ± 8.65%, and mean blood glucose was 229.47 ± 98.7 mg/dL. Multiple linear regression tests showed that HbA1c (B= 5,544; â=0.121; p=0.420) and GA (B=5.899; â=0.517; p=0.001) was signigicantly corelated with random blood gucose, respectively, indicating that glycated albumin is significantly related to and has the greatest influence on glucose level.ConclusionGlycated albumin is correlated with and has greater influence on glucose level than does HbA1c. Glycated albumin could be a better marker for glycemic control than glycated hemoglobin in diabetic patients treated with insulin.
Natural honey reduced atherogenic and coronary risk indices in Wistar rats
Authors: Olukanni Olumide David , Alagbe Yewande O. , Akande Oreoluwa T , Olukanni Adedayo T. , Daramola Gbenga G. , Adeyemi Oluyomi S.
Published: April 2020

BACKGROUNDThe biochemical mechanism underlying the nutraceutical effects of honey is poorly understood, thus making its functions more a matter of speculations. In this study, we investigated the effects of honey on the atherogenic and coronary risk indices in Wistar rats.METHODSAn experimental design comprising two groups of rats fed with normal rat chow but with the experimental group receiving 10% honey in water and the control group water alone, for five weeks. Blood samples were collected weekly from each group, and the level of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and total protein were determined. The lipids profile (total cholesterol, total triglycerides, LDL and HDL) were also determined, and the atherogenic and coronary indices were estimated. Data were analyzed, and p<0.05 was considered significant.RESULTSThere were no significant changes in both groups’ serum SOD and CAT across the weeks of study. The LDL cholesterol of the honey-treated rats, however, decreased significantly (9.95 mg/dL) compared to the controls (27.07 mg/dL) (p=0.000). In contrast, honey intake elevated the HDL cholesterol (18.37 mg/dL) relative to 12.25 mg/dL in the control group (p=0.003). Consequently, honey treatment caused significant depletion of atherogenic and coronary risk indices (76.13%, p=0.001) and (50.37%, p=0.023) respectively. CONCLUSIONWe show evidence that the regular intake of honey, at a concentration as low as ten percent of total water intake, may lower factors for the onset of hypertension and coronary diseases.
O EFEITO DA PROPAGANDA NA PREFERÊNCIA DE ESCOLHA DAS CRIANÇAS
Authors: SILVA ANDRÉ VASCONCELOS DA , SILVA LUCIANA MESQUITA DA
Published: April 2020

O objetivo do presente estudo foi investigar o efeito de estímulo discriminativo na escolha e preferência de crianças por bebidas. Para tanto foi realizado um experimento com 16 crianças de ambos os sexos, com idade entre 10 e 12 anos, com a utilização de um jogo de tabuleiro e apresentação de propagandas de bebidas: suco, refrigerante e uma propaganda de brinquedo. Os participantes foram divididos em quatro grupos, para cada grupo foi apresentado uma das propagandas antes do início do jogo, quando os mesmos teriam que fazer a escolha entre suco ou refrigerante durante 20 tentativas em cada sessão, sendo que foram realizadas duas sessões. Os resultados demonstraram que as propagandas não exerceram influência nas escolhas dos participantes, pois independente da propaganda exibida, as crianças demonstraram preferência pelo suco em detrimento ao refrigerante.
Object Recognition Through Artificial Intelligence Techniques
Authors: Ramírez-Arias José Luis , Rubiano-Fonseca Astrid , Jiménez-Moreno Robinson
Published: April 2020

This paper describes a methodology for object recognition categorized as polyhedron and non-polyhedron. This recognition is achieved through digital image processing combined with artificial intelligence algorithms, such as Hopfield networks. The procedure consists of processing images in search of patterns to train the system. The process is carried out through three stages: i) Segmentation, ii) Smart recognition, and iii) Feature extraction; as a result, images of objects are obtained and trained in the designed neuronal network. Finally, Hopfield's network is used to establish the object type as soon as it receives one. The proposed methodology was evaluated in a real environment with a considerable number of detected images; the noisy images recognition uncertainty was 2.6%, an acceptable result considering variable light, shape and color. The results obtained from this experiment show a high recognition level, which represents 97.4%. Out of this procedure, we can assume that it is possible to train new patterns, and it is expected that the model will be able to recognize them. Potentially, the proposed methodology could be used in a vast range of applications, such as object identification in industrial environments, grasping objects using manipulators or robotic arms, tools for blind patients, among other applications.
Merkezi Kompozit Dizayn Kullanılarak Kapesitabin Tayini için RPLC Yönteminin Geliştirilmesi ve Validasyonu
Authors: Daldal Yaşar Doğan , Çubuk Demiralay Ebru
Published: April 2020

Ters faz sıvı kromatografi (RPLC) yöntemi, merkezi kompozit dizayn (CCD) kullanılarak kapesitabinin analizi için geliştirilmiş ve valide edilmiştir. Metot üç faktörle (mobil faz organik modifiyer derişimi, mobil faz pH’sı ve kolon sıcaklığı) Minitab programı kullanılarak optimize edilmiştir. Optimum kromatografik koşullar, Derringer’in istenebilirlik fonksiyonu kullanılarak belirlenmiştir. CCD'nin yardımıyla tayin edilen ayırmanın optimum koşulları: (1) Mobil faz: asetonitril-su ikili karışımı oranı 40:60 (%h/h), (2) kolon sıcaklığı 32oC ve mobil fazın pH'sı 7,5'dur. Çalışma, YMC triart C18 (150x4,6 mm I.D, 3m) kolonda ve 1 mL/dakika akış hızında gerçekleştirilmiştir. Geliştirilen sıvı kromatografik yöntemin ICH parametrelerine göre validasyonu gerçekleştirilmiştir.
Investigating The Effect of Acrylic Latex on Moisture Susceptibility of Hot Mix Asphalt
Authors: Karahançer Şebnem
Published: April 2020

Polymers are popular materials as an additive to improve the performance of hot mix asphalt (HMA). To this aim, acrylic latex was chosen to improve the performance of asphalt mixture. In this study, it was investigated that the performance of hot mix asphalt with acrylic latex additive in three percentages (1%, 2% and 3%). Design bitumen contents were determined for all acrylic latex additive. Indirect Tensile Strength and moisture susceptibility of acrylic latex added HMA was conducted using test procedure of AASHTO T283. According to the results, design bitumen contents were increased by acrylic latex. Although the bitumen content was increased, both the indirect tensile (IDT) strength and the moisture resistance were improved by acrylic latex. Best performance was obtained by 3% acrylic latex additive. It is suggested that the percentage of acrylic latex would be increased for further researches.
Estimulación intramuscular con aguja seca versus laserterapia en síndrome miofascial lumbar
Authors: Castro Valencia Nelly Berioska
Published: April 2020

Objetivo: Conocer la efectividad analgésica de aguja seca ante laser terapia en el tratamiento del dolor por síndrome miofascial lumbar en la primera semana de tratamiento. Material y métodos: Estudio observacional, analítico de cohorte, incluyó a todos los pacientes con lumbalgia crónica inespecífica por síndrome miofascial que acudieron al servicio de rehabilitación del hospital Loayza en los meses de setiembre, octubre 2015 que cumplían los criterios de inclusión. Los pacientes para uno y otro grupo se escogieron aleatoriamente, especialistas en Rehabilitación entrenados en el diagnóstico y tratamiento del síndrome miofascial lumbar aplicaron ficha de recolección de datos y escala análoga visual de dolor. Resultados: El promedio de dolor inicial en el grupo de laser fue de 6,4; en el grupo de aguja seca fue de 6,8, a los 7 dias de aplicados los agentes la escala de dolor fue de 4 para laser y 4,3 para aguja seca. La edad media de los pacientes evaluados fue 54,78 años con una desviación típica de 11,52 años. El 77,6% de los pacientes evaluados son del sexo femenino. El 93,9% (46/49) de los pacientes evaluados son de Lima. Al 46,9% (23/49) se le aplico la técnica analgésica con laser de baja intensidad y al 53,1% (26/49) la técnica de estimulación intramuscular con aguja seca. Los niveles de dolor inicial y final según la escala visual análoga son estadísticamente iguales en los grupos evaluados (p=0,692). Conclusiones: No encontramos diferencias entre ambos grupos, ambas técnicas analgésicas bajaron el dolor en igual medida.
Efectividad de los ejercicios oculomotores para la insuficiencia de convergencia en adolescentes en tres instituciones educativas en la provincia de Lima
Authors: Antonio Rojas Abraham Alberto , Boza Huamán Geraldine Katherine , Espinoza Sánchez Fátima Alejandra , Vidal Valenzuela Lupe Ysabel , Reyes Díaz Jorge
Published: April 2020

La insuficiencia de convergencia es la incapacidad de converger ambos ojos en un mismo punto, genera dificultades en los adolescentes a la hora de realizar las actividades escolares por ello detectarla y tratarla a tiempo es importante. Objetivo: Determinar la efectividad de los ejercicios oculomotores en adolescentes con insuficiencia de convergencia en tres instituciones educativas de Lima.Material y métodos: estudio cuasi-experimental, utilizando como referencia la evaluación oftalmológica antes y después del tratamiento. A los adolescentes que presentaban insuficiencia de convergencia (IC) se les realizo ejercicios oculomotores por un periodo de 1 mes las evaluaciones pre tratamiento y pos tratamiento fue realizada por el oftalmólogo. Resultados: Se evaluaron 321 adolescente de los cuales 225 (70,1%) presentaron IC de ellos 190 cumplieron los criterios de inclusión, solo 56 adolescentes cumplieron la terapia de ejercicios oculomotores, siendo 19 del género femenino (33,9%) y 37 del género masculino (66.1%). La puntuación de la IC con la regla de Krimsky en los adolescentes presento una media del 14,2 ± 1,4 cm. para el género femenino y 14,5 ± 1,43cm para el género masculino. La mediana de la puntuación de Punto Proximal de Convergencia (PPC) pre ejercicios oculomotores fue 14 cm (p25 12,6cm - p75 15,3cm), y post tratamiento fue 10,6 cm (p25 9,5cm - p75 13,3cm) siendo esta diferencia significativa (p<0,05). Conclusión: Los ejercicios activos oculomotores en adolescentes disminuyen la insuficiencia de convergencia y puede usarse como tratamiento fisioterapéutico y adyuvante del tratamiento oftalmológico en la IC.
Aspectos psico-espirituales medidos con la FACIT-Sp en pacientes con cáncer estadio IV
Authors: Pedraz-Petrozzi Bruno , Mendoza-Saldaña Juan Diego , Altamirano-Quiroz Astrid , Saldivar-Ampuero Gustavo , Pilco-Inga Jorge , Pando-Alvarez Fiorella , Samamé-Perez-Vargas Juan-Carlos
Published: April 2020

Objetivo: Describir los diferentes elementos psico-espirituales en pacientes con cáncer aplicando la escala Functional Assessment of Chronic Illness Therapy - Spiritual Well Being, FACIT-Sp (Evaluación Funcional de Terapia de Enfermedades Crónicas y Bienestar Espiritual). Métodos: Aplicación de la escala a una muestra de pacientes (n = 100) con diagnóstico de cáncer, estadio IV, del Servicio de Oncología del Hospital Nacional Arzobispo Loayza. El instrumento de 33 preguntas examina cinco áreas: bienestar social (SWB), bienestar emocional (EWB), bienestar funcional (FWB), sentido y paz (MP) y fe (F). Resultados: En la muestra estudiada, el aspecto más resaltante fue el relacionado con F (puntaje promedio=13,53 ± 3,05, correspondiente al 84,56% del puntaje máximo posible) y el más bajo fue el vinculado a FWB (puntaje promedio=15,79 ± 6,89, correspondiente al 56,39% del puntaje máximo posible). Conclusiones: De acuerdo a FACIT-Sp, el aspecto psico-espiritual más desarrollado en los pacientes de la muestra estudiada fue el relativo a la Fe y el menos desarrollado, el vinculado al área de Bienestar Funcional.
Comparación del perfil cognitivo de pacientes con alcoholismo y esquizofrenia
Authors: Belon-Hercilla Maria V. , Denegri-Solís Lucia , Soto-Añari Marcio
Published: April 2020

Estudios recientes muestran que una alta prevalencia de trastornos psicóticos y por consumo de sustancias comparten mecanismos cerebrales comunes que pueden afectar el rendimiento cognitivo, la adhesión al tratamiento y, con ello, aumentar el riesgo de recaídas. Objetivo: Comparar el rendimiento cognitivo en pacientes con alcoholismo y con esquizofrenia. Material y Métodos: Estudio observacional que evaluó a 18 pacientes con esquizofrenia y 32 con trastorno mental debido a consumo de alcohol. Se utilizó la batería neuropsicológica breve NEUROPSI, validada en español. Resultados: Se encontraron diferencias significativas entre ambos grupos en áreas de función ejecutiva y memoria declarativa (a largo plazo), con mayores puntajes de deterioro en el grupo de pacientes con esquizofrenia. Conclusiones: Los resultados permiten comprender y explicar las dificultades observadas en pacientes con esquizofrenia en cuanto a funciones de regulación conductual y recuperación de información.
Sexualidad y homosexualidad en la obra de Carlos Alberto Seguin
Authors: Huarcaya-Victoria Jeff
Published: April 2020

La sexualidad ha sido siempre un tema de interés tanto en círculos académicos como para el público en general. El concepto de “lo normal” en la sexualidad estuvo relacionado con cuestiones morales, religiosas o legales hasta el siglo XIX, a partir del cual se le comenzó a relacionar con conceptos y temas médicos. En comparación con otros psiquiatras de su época, Carlos Alberto Seguin dio mucha importancia al estudio de la sexualidad humana. Consideró que el desequilibrio de una personalidad puede verse reflejado directamente en su actividad psico-sexual, por lo cual es necesario indagar detenidamente acerca de élla. Las “desviaciones sexuales”, con la homosexualidad como paradigma, suscitan tanto o más interés. La historia de la homosexualidad en el campo de la psiquiatría es compleja, algunos psiquiatras mantenían un enfoque de soporte y menos punitivo, mientras que otros jugaron un papel importante en el tratamiento médico de las conductas homosexuales. Seguin no consideró a la homosexualidad como una enfermedad, si bien la entendía como algo no deseable, contrapuesto al ideal de heterosexualidad. En base a su práctica clínica, postuló un sistema de clasificación de la homosexualidad y mantuvo una actitud comprensiva hacia ella, aun cuando no examinó de una manera directa las opiniones sociales y culturales sobre el tema, en el Perú de su época.
La cura de sueño en la historia
Authors: Stucchi-Portocarrero Santiago , Cortez-Vergara Carla
Published: April 2020

A finales del siglo XIX comenzaron a utilizarse sustancias tales como los bromuros para inducir sueño profundo en personas con trastornos mentales. El uso de barbitúricos con el mismo fin fue reportado por Epifanio en 1913, pero fue Kläsi quien difundió con más éxito la administración de aquellos medicamentos, particularmente el Somnifen, y la denominó “cura de sueño prolongado” o “narcosis prolongada” (dauernarkose), a partir de la década de 1920. En 1934 se introdujo el Cloettal, una mezcla de barbitúricos y otros compuestos, en reemplazo del Somnifen. El uso de este procedimiento declinó con la aparición de otros métodos terapéuticos, pero continuó por varias décadas. En la Unión Soviética, la cura de sueño estuvo influida por la doctrina pavloviana, y se usó tanto para trastornos mentales como para padecimientos considerados psicosomáticos. El mayor desprestigio del método se dio en el Hospital de Chelmsford, en Australia, donde se reportaron 25 muertes asociadas a su uso durante el periodo 1963-1979. En el 2009, el Colegio Real de Psiquiatras de Australia y Nueva Zelanda concluyó que “la terapia de sueño profundo y la administración de barbitúricos endovenosos no tiene lugar en el tratamiento de trastornos psiquiátricos”. Aun cuando en la actualidad no forma parte de ningún tratamiento convencional, la cura de sueño sigue siendo ofrecida y solicitada.
Impacto de la epidemia del Coronavirus (COVID-19) en la salud mental del personal de salud y en la población general de China
Authors: Lozano-Vargas Antonio
Published: April 2020

En la lucha contra la epidemia del Coronavirus (COVID-19), el personal de salud puede experimentar problemas de salud mental tales como estrés, ansiedad, síntomas depresivos, insomnio, negación, ira y temor. En un estudio en China se observó que la tasa de ansiedad del personal de salud fue del 23,04%, mayor en mujeres que en hombres y mayor entre las enfermeras que entre los médicos. Asimismo, en la población general de China se observó un 53,8% de impacto psicológico moderado a severo; un 16,5% de síntomas depresivos, un 28,8% de síntomas ansiosos y un 8,1% de estrés, todos entre moderados y severos. Los factores asociados con un alto impacto psicológico y niveles elevados de estrés, síntomas de ansiedad y depresión fueron sexo femenino, ser estudiante, tener síntomas físicos específicos y una percepción pobre de la propia salud. Otro estudio en el mismo país detectó un 35% de distrés psicológico en la población general, con las mujeres presentando mayores niveles que los varones, al igual que los sub-grupos de 18-30 años y los mayores de 60 años. La pandemia plantea pues el desafío de cuidar la salud mental del personal de salud tanto como la de la población general. Así, el uso de instrumentos breves de detección de problemas de salud mental, validados en nuestra población, sería de mucha utilidad para los retos de salud pública que afronta el país.
Anorexia nervosa con desenlace fatal: a propósito de un caso
Authors: Aliaga-Tinoco Stephanie , Cruzado Lizardo
Published: April 2020

La Anorexia Nervosa (AN) es el trastorno psiquiátrico con mayor nivel de mortalidad directa y, a la vez, causa de múltiples y riesgosas complicaciones somáticas tales como: bradicardia, hipotensión ortostática, arritmias cardiacas, hipoglicemia, falla hepática, alteraciones hidroelectrolíticas y hormonales, osteopenia, dilatación gástrica y, finalmente, muerte súbita por diferentes causas. A pesar de su prevalencia relativamente baja, afecta a personas jóvenes con larga expectativa de vida. Su manejo, cuando llega a niveles de gravedad severa (IMC < 15), es complejo, pues requiere trabajo conjunto de psiquiatría y otras especialidades médicas y puede tener consecuencias ominosas. Se presenta y discute el caso de una paciente mujer de 19 años cuyo IMC llegó a 11 y que, lamentablemente, falleció mientras recibía atención hospitalaria. Se revisan las principales complicaciones médicas de la AN, remarcándose la necesidad de considerar los parámetros pertinentes para una atención hospitalaria oportuna que pueda evitar desenlaces fatales.
Desaconsejable uso de haloperidol intravenoso en psiquiatría
Authors: Poma-Gálvez Jonnathan , Cruzado Lizardo
Published: April 2020

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Comic-Based Module Development Andro-Web to Improve Problem Solving Ability in Physics in High School Students
Authors: Annisa Suci Arin , Lesmono Albertus Djoko , Yushardi Y
Published: April 2020

This research aims to determine the validity of comic-based module andro-web on the subject of an ideal gas and increased capacity problem-solving physics students after using comic-based module andro-web on the subject an ideal gas. The research uses the design nieveen model of development. In the assessment phase, the module then tried out on 30 grade XI science 2 Jenggawah Senior High School. The instruments of product quality are an instrument validation and instrument increased capacity problem solving of physics students about pre-test and post-test completed by using 5 indicators problem-solving. The average score validation comic-based module andro-web by validator 81,7 % with valid category. The score validation by user validator obtained score 93,3 % with a very valid category. Besides, increased capacity problem-solving physics students a score was obtained for 47,3 % in by test n-gain medium category. Thus, it was stated that comic-based module andro-web can be used in teaching material XI science class and will raise the ability problem-solving physics students on the subject of an ideal gas.
Development of B D F-AR 2 (Physics Digital Book Based Augmented Reality) to train students' scientific literacy on Global Warming Material
Authors: Kholiq Abd.
Published: April 2020

There have been many developments in digital books, but they are different from BDF-AR2 (Physics Digital Book Based Augmented Reality), this is because the developed BDF-AR2 has features that can train the literacy skills of learners including Augmented Reality (AR) feature so that learning can be more real.  The main objective of this research is to describe eligibility (validity, practicality, and effectiveness) of BDF-AR2 media that has been developed This research employed Hannafin & Peck Model development design using by using instruments of media validation, learning completion and validated test instrument. Media validation was carried out by three media experts and resulted in the media B D F-AR 2 (Physics Digital Book Based Augmented Reality) on the global warming material is classified as very valid (93.5%). As for practicality (use BDF-AR2 media in learning) is obtained 83.29% and categorized very good. While for effectiveness (students' scientific literacy skills), it was found that students' scientific literacy skills for 36.67% of students are in a good category, 56.67% of student have an average level and 6.96% of students had poor category for literacy competence science in explaining the phenomenon. As for scientific literacy competencies in interpreting data and evidence scientifically, 30% students have good grades, 66.67% had a fair grade and 3.33 had a poor grade. Referring to the results of validity, practicality, and effectiveness of use BDF-AR2 in learning, it can be concluded that the developed BDF-AR2 is feasible to use in learning. The implication of this research is to present a media that supports 21st-century learning that has been proclaimed by the government.