bluuebunny/crossref_metadata_2025 huggingface dataset:
Mastering Innovations in the Lens of Information and Communications Technology (ICT) Competence and Practices of 21stCentury Filipino Teachers: A Comparison among Thailand, Vietnam, and the Philippines
Authors: Hero Jesson L. , Zulueta Ma. Cristina E. , Gloria Daianne S. , Tongol Jose Carlo L. , Cruz Aaron C. Dela , Sagun Sr. Angelita T. , Cajurao Fr. Gil V. , Cabrera Wendell C.
Published: July 2021

In the advent of Information and Communications Technology in education, competence and skills for technology-based instruction are essential for teachers. With this, there is a need to continually train and equip teachers with understanding and capabilities that will enable them to maximize the utilization of ICT in their instructional practices. Hence, this research determined the correlation of teachers' level of ICT competence towards their ICT integration practices and corroborated it to existing findings in Thailand and Vietnam. Using a descriptive-correlational design, the researchers found a link between and among variables. The chosen respondents for the study consisted of onehundred and nineteen (119) teachers from private institutions in a district in Bulacan. Results showed that teachers exhibited competence towards ICT integration. More so, teachers highly practiced ICT integration as part of their instructional practices and strategies in teaching. Results of regression analysis of the data revealed that the six dimensions of ICT competence significantly correlated to the teachers' ICT integration practices. The pedagogical practices and competence of Filipino teachers are the same as the Thai and Vietnamese teachers towards ICT Integration. It is recommended that schools maintain teachers' competence and confidence towards ICT integration thru enhancement or faculty development programs.
Inclusão reversa e voleibol sentado: direitos humanos em jogo
Authors: Silva Maria Denise Dourado da , Cardoso Layana Costa Ribeiro , Almeida Dulce Maria Filgueira de
Published: July 2021

O presente artigo tem por objetivo apresentar a Inclusão Reversa e os sentidos de corpo com deficiência como possível estratégia pedagógica para o ensino no contexto de aulas de Educação Física. Os termos “Inclusão Reversa” e “corpo com deficiência” foram identificados por meio de pesquisa bibliográfica, realizada em livros e artigos científicos no período compreendido de 2000 a 2020. Complementarmente, foram consultadas as legislações a respeito. Verificou-se que, além de possuirmos legislação adequada ao tema, há um avanço, em termos da literatura científica, para a adoção de termos como corpo com deficiência e Inclusão Reversa, como estratégia pedagógica. O desafio contingente à Educação Física se refere ao projeto de formação de professores comprometido com uma preparação pedagógico-didática que assegure domínio de conhecimentos necessários à compreensão da realidade social, tendo em vista que as necessidades, os interesses e as condições não são iguais para todos.
Dotação física e talento esportivo: investigações acadêmicas na educação infantil
Authors: Rossi Carlos Samuel , Rangni Rosemeire de Araújo
Published: July 2021

A dotação física e o talento esportivo se manifestam nesse modelo por desempenhar papel significativo no grande conjunto de influências das habilidades físicas naturais unidas às competências treináveis dadas pelo processo desenvolvimentista proporcionado pelo ambiente. O referencial foi o Differentiated Model of Giftedness and Talent (DMGT), de Gagné. Assim, o objetivo geral foi investigar a interface Dotação e Talento e Educação Física na Educação Infantil. A metodologia empregada foi a pesquisa bibliográfica de natureza qualitativa. Foram buscados trabalhos acadêmicos em dois bancos de dados: Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) e Scientific Eletronic Library Online (SciELO), com recorte temporal de cinco anos. Os resultados obtidos foram quatro produções encontradas: uma tese e três dissertações defendidas nos anos de 2017 e 2019. Concluiu-se que há poucas pesquisas que abordem especificamente a dotação física e talento esportivo na Educação Infantil, sendo que as produções encontradas versam sobre outros níveis de ensino. Isso ressalta a importância de se olhar para as crianças dotadas e talentosas desde o início do percurso educacional.
Estágio supervisionado na instituição de ensino superior como direito humano aliado a formação da identidade docente
Authors: Carrascoza Lucas Sertorio , Silveira Sergio Roberto
Published: July 2021

A Declaração Universal dos Direitos Humanos (DUDH) representou a coligação entre as nações a fim de assegurar direitos básicos humanos como o direito ao acesso, a igualdade, a liberdade, a proteção e a permanência. Nesse panorama, o direito a educação constitui-se como um dos direitos fundamentais mais relevantes para o futuro da humanidade, como símbolo da aquisição do conhecimento. Aliado a isso, a educação no ensino superior torna-se um elemento chave tanto para a formação inicial como continuada, na medida em que promove o alinhamento entre teoria e prática, por meio de disciplinas universitárias que envolvem o estágio supervisionado. Portanto, o objetivo desse ensaio é analisar a importância do estágio supervisionado no ensino superior como um direito humano aliado a formação da identidade docente. Por fim, há uma forte ligação entre os direitos humanos assegurados na DUDH e a formação da identidade docente, por meio de um processo de estágio supervisionado no ensino superior.
CAEFE USP e a importância da organização estudantil como potencializadora dos direitos humanos
Authors: Vale Pedro Henrique Rodrigues do , Marante Júlia Silveira , Queiroz Marcos Kauê Ferreira de , Silveira Sergio Roberto
Published: July 2021

O Centro Acadêmico da Escola de Educação Física e Esporte da Universidade de São Paulo (CAEFE USP) foi fundado em 15 de dezembro de 1955 com o nome de Centro Acadêmico Ruy Barbosa (até 2019). Desde então, participa ativamente da construção da vida acadêmica junto aos setores da universidade. A Declaração Universal dos Direitos Humanos (DUDH) foi aprovada na Assembleia Geral das Nações Unidas, em dezembro de 1948 e daí em diante sofre ameaças e violações, sendo necessária a atuação de vários segmentos da sociedade a fim de assegurar e potencializar os direitos contidos em seu teor. A universidade é um sítio de inovação, mas também pode refletir mazelas sociais. Pretende-se, neste ensaio, relacionar as ações desenvolvidas pelo CAEFE USP a partir da ótica de ações que potencializem os Direitos Humanos (DH). Após contextualização a respeito da temática e do movimento estudantil, são expostas algumas ações do CAEFE-USP, relacionando-as diretamente com Artigos da Declaração. Com isso, visa-se entender a maneira que o CAEFE-USP ratifica e promove os DH, assim como a forma que a DUDH norteia e fundamenta as ações do CAEFE USP.
O pensamento de Arlindo Machado e uma genealogia das artes do vídeo no Brasil
Authors: Bastos Marcus
Published: July 2021

A obra de Arlindo Machado estabelece o principal campo de leitura das artes do vídeo no Brasil. Em especial em dois artigos, A experiência do vídeo no Brasil e As linhas de força do vídeo brasileiro, Machado traça um panorama – que ele mesmo sinaliza ser incompleto – da produção videográfica no país. Este artigo propõe-se uma tarefa dupla: demonstrar de que forma a obra de Machado contribui para a formação de um campo de pesquisa que propõe a leitura crítica das imagens técnicas, o que ele faz de dois modos complementares (pelo desmonte das linguagens estabelecidas e pelo mapeamento das linguagens emergentes); reestabelecer elos que não foram desenvolvidos de forma mais longa entre as artes visuais e as artes do vídeo, propondo uma genealogia das artes do vídeo no Brasil a partir da análise de duas obras representativas.
Luz vital ao poço escuro
Authors: Veloso Josafá
Published: July 2021

Resenha do e-book Pandemídia: vírus, contaminações e confinamento, idealizado pelo LabArteMídia (Laboratório de Arte, Mídia e Tecnologias Digitais), grupo de pesquisa vinculado ao Departamento de Cinema, Rádio e Televisão e ao Programa de Pós- Graduação em Meios e Processos Audiovisuais da Escola de Comunicações e Artes. Por nove meses, a partir de abril de 2020, um transdisciplinar grupo de pesquisadores e artistas se propôs a elaborar uma série de textos que vão do artigo acadêmico, crônica, ficção, ao ensaio, passando pelo relato de experiências artísticas de resistência poética em pleno isolamento.
Representações e discursividades da educação na comunicação
Authors: Budag Fernanda Elouise
Published: July 2021

From the perspective of theories on audiovisual narrative and studies on communication and education, we analyze a contemporary fictional TV show, Merlí, produced in Spain, aired in Brazil via a streaming platform, and whose theme approaches the educational environment and its issues. Our interest is to capture the speeches and representations that gain, in this recent media product, the figure of the teacher and the image of education; particularly the teacher and the teaching of Philosophy. Undertaking a theoretical reflection of the situated empirical object, we question if there is either a reproduction of teaching stereotypes, or their breaking; and what are the statements currently built on education.
Metodologia projetual para educomunicar o desenvolvimento de coleções de moda
Authors: Ghisleni Taís Steffenello , Sandri Rubiana de Quadros , Becker Elsbeth Léia Spode
Published: July 2021

El objetivo del artículo es describir una propuesta de práctica educomunicativa para recrear metodologías de diseño en la enseñanza y el desarrollo de colecciones de moda. La metodología es cualitativa basada en la revisión de la literatura. El texto presenta una breve comprensión de las metodologías de diseño en el desarrollo de colecciones de moda basadas en los auotres Montemezzo (2003), Jones (2005), Barcaro (2008), Sorger y Udale (2009), Renfrew (2010) y Treptow (2013) , además de describir algunas metodologías utilizadas en el diseño de moda y presenta una propuesta para la práctica educomunicativa en la enseñanza y el desarrollo de colecciones de moda. Se infirió que las metodologías de diseño para el desarrollo de colecciones de moda pueden utilizar prácticas educativas y así facilitar el proceso de enseñanza en el desarrollo de colecciones, articulando el proceso de colaboración entre los estudiantes.
The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene
Ppm1d
Promotes Inflammation and Non-Ischemic Heart Failure in Mice
Authors: Yura Yoshimitsu , Miura-Yura Emiri , Katanasaka Yasufumi , Min Kyung-Duk , Chavkin Nicholas , Polizio Ariel H. , Ogawa Hayato , Horitani Keita , Doviak Heather , Evans Megan A. , Sano Miho , Wang Ying , Boroviak Katharina , Philippos George , Domingues Ana Filipa , Vassiliou George , Sano Soichi , Walsh Kenneth
Published: July 2021

Rationale:

Cancer therapy can be associated with short- and long-term cardiac dysfunction. Patients with cancer often exhibit therapy-related clonal hematopoiesis (t-CH), an aggressive form of clonal hematopoiesis that can result from somatic mutations in genes encoding regulators of the DNA-damage response (DDR) pathway. Gain-of-function mutations in exon 6 of the protein phosphatase Mg2+/Mn2+ dependent 1D (
PPM1D
) gene are the most frequently mutated DNA-damage response gene associated with t-CH. Whether t-CH can contribute to cardiac dysfunction is unknown.

Objective:

We evaluated the causal and mechanistic relationships between
Ppm1d
-mediated t-CH and nonischemic heart failure in an experimental system.

Methods and Results:

To test whether gain-of-function hematopoietic cell mutations in
Ppm1d
can increase susceptibility to cardiac stress, we evaluated cardiac dysfunction in a mouse model where clonal hematopoiesis-associated mutations in exon 6 of
Ppm1d
were produced by CRISPR-Cas9 technology. Mice transplanted with hematopoietic stem cells containing the mutated
Ppm1d
gene exhibited augmented cardiac remodeling following the continuous infusion of Ang II (angiotensin II).
Ppm1d
-mutant macrophages were impaired in DDR pathway activation and displayed greater DNA damage, higher reactive oxygen species generation, and an augmented proinflammatory profile with elevations in IL (interleukin)-1β and IL-18. The administration of an NLRP3 (NLR family pyrin domain containing 3) inflammasome inhibitor to mice reversed the cardiac phenotype induced by the
Ppm1d
-mutated hematopoietic stem cells under conditions of Ang II–induced stress.

Conclusions:

A mouse model of
Ppm1d
-mediated t-CH was more susceptible to cardiac stress. Mechanistically, disruption of the DDR pathway led to elevations in inflammatory cytokine production, and the NLRP3 inflammasome was shown to be essential for this augmented cardiac stress response. These data indicate that t-CH involving activating mutations in
PPM1D
can contribute to the cardiac dysfunction observed in cancer survivors, and that anti-inflammatory therapy may have utility in treating this condition.
Penetrance of Severe Pulmonary Arterial Hypertension in Response to Vascular Endothelial Growth Factor Receptor 2 Blockade in a Genetically Prone Rat Model Is Reduced by Female Sex
Authors: Chaudhary Ketul R. , Deng Yupu , Yang Anli , Cober Nicholas D. , Stewart Duncan J.
Published: July 2021

Background

We have previously reported important strain differences in response to SU5416 (SU, a vascular endothelial growth factor receptor 2 inhibitor) in rats and have identified a specific colony of Sprague‐Dawley rats that are hyperresponsive (SD
HR
) to SU alone and develop severe pulmonary arterial hypertension (PAH) with a single injection of SU, even in the absence of hypoxia. Interestingly, SD
HR
rats exhibit incomplete penetrance of the severe PAH phenotype with an “all‐or‐none” response to SU alone, which provides a unique opportunity to assess the influence of female sex and sex hormones on susceptibility to PAH after endothelial injury in a genetically prone model.

Methods and Results

SD
HR
rats were injected with SU (20 mg/kg SC) and, in the absence of hypoxia, 72% of male but only 27% of female rats developed severe PAH at 7 weeks, which was associated with persistent endothelial cell apoptosis. This sex difference in susceptibility for severe PAH was abolished by ovariectomy. Estradiol replacement, beginning 2 days before SU (prevention), inhibited lung endothelial cell apoptosis and completely abrogated severe PAH phenotype in both male and ovariectomized female rats, while progesterone was only protective in ovariectomized female rats. In contrast, delayed treatment of SD
HR
rats with established PAH with estradiol or progesterone (initiated at 4 weeks post‐SU) failed to reduce lung endothelial cell apoptosis or improve PAH phenotype.

Conclusions

Female sex hormones markedly reduced susceptibility for the severe PAH phenotype in response to SU alone in a hyperresponsive rat strain by abolishing SU‐induced endothelial cell apoptosis, but did not reverse severe PAH in established disease.
Greater Adherence to Secondary Prevention Medications Improves Survival After Stroke or Transient Ischemic Attack: A Linked Registry Study
Authors: Dalli Lachlan L. , Kim Joosup , Cadilhac Dominique A. , Greenland Melanie , Sanfilippo Frank M. , Andrew Nadine E. , Thrift Amanda G. , Grimley Rohan , Lindley Richard I. , Sundararajan Vijaya , Crompton Douglas E. , Lannin Natasha A. , Anderson Craig S. , Whiley Leanne , Kilkenny Monique F.
Published: July 2021

Background and Purpose:

Although a target of 80% medication adherence is commonly cited, it is unclear whether greater adherence improves survival after stroke or transient ischemic attack (TIA). We investigated associations between medication adherence during the first year postdischarge, and mortality up to 3 years, to provide evidence-based targets for medication adherence.

Methods:

Retrospective cohort study of 1-year survivors of first-ever stroke or TIA, aged ≥18 years, from the Australian Stroke Clinical Registry (July 2010–June 2014) linked with nationwide prescription refill and mortality data (until August 2017). Adherence to antihypertensive agents, statins, and nonaspirin antithrombotic medications was based on the proportion of days covered from discharge until 1 year. Cox regression with restricted cubic splines was used to investigate nonlinear relationships between medication adherence and all-cause mortality (to 3 years postdischarge). Models were adjusted for age, sex, socioeconomic position, stroke factors, primary care factors, and concomitant medication use.

Results:

Among 8363 one-year survivors of first-ever stroke or TIA (44% aged ≥75 years, 44% female, 18% TIA), 75% were supplied antihypertensive agents. In patients without intracerebral hemorrhage (N=7446), 84% were supplied statins, and 65% were supplied nonaspirin antithrombotic medications. Median adherence was ≈90% for each medication group. Between 1% and 100% adherence, greater adherence to statins or antihypertensive agents, but not nonaspirin antithrombotic agents, was associated with improved survival. When restricted to linear regions above 60% adherence, each 10% increase in adherence was associated with a reduction in all-cause mortality of 13% for antihypertensive agents (hazard ratio, 0.87 [95% CI, 0.81–0.95]), 13% for statins (hazard ratio, 0.87 [95% CI, 0.80–0.95]), and 15% for nonaspirin antithrombotic agents (hazard ratio, 0.85 [95% CI, 0.79–0.93]).

Conclusions:

Greater levels of medication adherence after stroke or TIA are associated with improved survival, even among patients with near-perfect adherence. Interventions to improve medication adherence are needed to maximize survival poststroke.
On Epigenesis
Authors: Miller Alexander , Malabou Catherine , Apter Emily , Szendy Peter , Bianchi Emanuela , Galloway Alexander R.
Published: July 2021

“On Epigenesis” consists of a series of interrelated short articles examining the philosophical concept of epigenesis, with a particular focus on Catherine Malabou's development of it in contemporary thought.

Alexander Miller introduces the topic of epigenesis and considers its significance as a new paradigm. He also presents the reader with an overview of Malabou's work on the topic: Drawing from recent advances in the life sciences as well as the Western philosophical tradition, he claims, Malabou has proposed “an epigenetic paradigm for rationality” for the 21st century.

Catherine Malabou explains that when, in 2001, the scientific journal Nature published virtually the entire sequence of three billion bases that make up the human genome, people were surprised: Only five percent of the sequence turned out to actually be genes. Assembled in bunches and clusters, they are separated by vast expanses of so-called gene deserts made up of DNA characterized as “junk” or “repetitive,” which is to say, non-coding. The sequencing of the genome did not offer the revelations that people had expected, marking the end of the “everything is genetic” creed and announcing the rise of the “epigenetic paradigm.” The present article analyzes the implications of this new paradigm in biology, philosophy, and hermeneutics.

Emily Apter situates Catherine Malabou's theory of epigenesis within a broader disciplinary context of Continental philosophy, the cognitive turn, and what a brain does or “is” as an object of aesthetic representation.

Peter Szendy argues that even if they are not the central focus of her philosophical work, media and medial metaphors play a key role in Catherine Malabou's understanding of epigenetics. Indeed, her views on the epigenetic paradigm shift could lead to a rethinking of mediality. A medium, according to such an epigenetic approach, would be neither simply a storage space nor a carrier: It would be what happens along with the events (whether they involve works or data) that it hosts or transports.

Emanuela Bianchi asks whether the epigenesis of “pure reason” can in any sense be “pure,” since epigenesis necessarily involves empirical processes. Foregrounding the topological involvement of the developing organism in its environment in both biological and psychoanalytic registers, she suggests a way forward can be found in thinking of the genesis of reason as both empirical and rational.

Alexander R. Galloway traces an etymological path from “epigenetic” back to the Greek verb “gignomai,” meaning “to be born” or “to become.” But what is becoming? And why is becoming better than (mere) being? One answer is that becoming helps one to escape the confines of identity and rote determination. But what happens when the epigenetic paradigm becomes dominant, when contingency, evolution, and becoming prevail over essence, stasis, and determinism?
Islamic Ethics and the COVID-19 Pandemic: A Report on an Interdisciplinary 2020 Summer School
Authors: Elzamzamy Khalid
Published: July 2021

The COVID-19 pandemic has touched every aspect of human life and posed a myriad of ethical questions. In an attempt to equip graduate students with the necessary tools to explore the pandemic-related questions from an Islamic perspective, a summer school titled “Islamic Ethics and the Covid-19 Pandemic” was co-organized by the Center for Islamic Legislation and Ethics, Qatar and the Leuven Centre for the Study of Islam and Society, Belgium from 9 to 12 August, 2020. The purpose of this report is to provide an overview of topics discussed during the school and to highlight a plethora of references which may be consulted for more information on the topic.
Pleopeltis (Polypodiaceae) in Brazil
Authors: DE SOUZA FILIPE SOARES , SALINO ALEXANDRE
Published: July 2021

Polypodiaceae is notable for being one of the richest, most diverse, and abundant groups of ferns in tropical and subtropical forests. Currently, 65 genera and approximately 1652 species are recognized in the family. Pleopeltis is a monophyletic genus and comprises approximately 90 species, most of which are exclusive to the Neotropics. The aim of this scientific contribution is a taxonomic treatment of the Pleopeltis species occurring in Brazil. It has been based on the morphological data of specimens from Brazilian and foreign herbaria, as well as on observations and collections made in the field. Eighteen species are recognized in Brazil and occur in all Brazilian biomes, notably the Atlantic Forest (16 spp.). At least one species occurs in all Brazilian states, and the states of Espírito Santo and Minas Gerais (southeastern Brazil) are the richest (11 spp. each). According to the Brazilian Flora Red List, three species are officially threatened, P. alborufula and P. monoides are endangered, and P. trindadensis is critically endangered; however, we suggest including two more species in the official list: P. aturensis and P. stolzei. The taxonomic treatment includes a genus description, identification key to the species, synonyms, species description, distribution maps, illustrations, list of specimens studied, taxonomic comments, and information on habitat and distribution.
Three new species of Polyalthia (Annonaceae) from Thailand and Laos
Authors: BUNCHALEE PASAKORN , JOHNSON DAVID M. , MURRAY NANCY A. , CHALERMGLIN PIYA
Published: July 2021

Three new species of Polyalthia are described and illustrated. Two of the new species are part of the Polyalthia evecta species complex, while the third species belongs to a species group including P. cinnamomea and P. stenopetala.
Additions to the knowledge of the fauna of the tribe Cryptini Kirby, 1837 (Hymenoptera, Ichneumonidae, Cryptinae) of Iran
Authors: HEYDARI MARYAM ZARDOUEI , RAKHSHANI EHSAN , MOKHTARI AZIZOLLAH , SCHWARZ MARTIN
Published: July 2021

Using Malaise traps, sweep nets and yellow pan traps during 2013–2015 in various localities of Iran, 18 species belonging to 11 genera in the tribe Cryptini Kirby, 1837 (Hymenoptera, Ichneumonidae, Cryptinae) were collected. Among them, five species including Aritranis longicauda (Kriechbaumer, 1873), Gambrus ornatus (Gravenhorst, 1829), Mesostenus dentifer (Thomson, 1896), Mesostenus kozlovi Kokujev, 1909 and Stenarella domator (Poda, 1761) are new records for the fauna of Iran. Sixty other species previously recorded from Iran are considered credible, bringing the number of known Iranian Cryptini to 65 species.
Nanostructured Composite Catalyst for Electrochemical Water Splitting: Significantly Improved for Hydrogen Evolution Reaction
Authors: Qayoom Mugheri Abdul , Soomar Samtio Muhammad , Memon Shahzad Ahmed
Published: July 2021

The evolutionary and rational design we incorporated for an efficient nonprecious metal nanocom-posite electrocatalysts for the hydrogen production which is a scientific challenge in the field of renewable energy. Herein, we report a simple and very active, the functional electrocatalyst for water oxidation which is highly demanded. It is of great prime importance for hydrogen evolution reaction (HER) which significantly contributes to renewable technologies. The values for electrocatalysts are NiCo2O4and NiCo2O3/P Tafel slope 66 and 42 mV/decade and overpotential of 382 and 320 mV and current density achieved at 10 mA/cm2anin 1.0 M KOH. The composites are characterized by SEM, HR-TEM, X-ray diffraction, XPS, and SAED. The NiCo2O3/P having high durability measured for 50 hours and its EIS results holding a small charge transfer resistance 28.81 Ohms (Ω) and capacitance containing 0.81 mF. Finally, we give an outlook for the development of these nanoma-terials in the short- and mid-term, highlighting the critical challenges to confront for a lab-to-real life transition of these highly promising nanocomposites.
Recent Insights into the Potential of Magnetic Metal Nanostructures as Magnetic Hyperthermia Agents
Authors: R. Aarathy A. , S. Gopika M. , Savitha Pillai S.
Published: July 2021

The advancements in magnetic nanoparticle mediated hyperthermia give so many optimistic and fruitful results that make it a promising and complementary approach for the existing treatment modalities of cancer. This thermotherapy is gaining wide acceptance among the medical community
compared to the conventional treatment methods. The former provides a local heat generation in the malignant tumor cells and remains non-invasive to the adjacent healthy cells. The increased heating efficiency of magnetic nanoparticles and the control of local therapeutic temperature are the
main challenges of hyperthermia. Superparamagnetic Iron Oxide nanoparticles have been intensively studied and dominating in magnetic hyperthermia. Recently many researchers successfully demonstrated high heating efficiency and biocompatibility of a wide variety of magnetic metal nanoparticles
and proposed as the most promising alternative for traditional iron oxides, which opens up a new avenue for magnetic metal nanoparticles in magnetic hyperthermia. The review presents the recent advancements that occurred in the field of metal nanoparticle mediated magnetic hyperthermia. The
theory underlying heat generation, synthesis methods, biofunctionalization, Specific Absorption Rate studies, challenges and future perspectives of magnetic metal nanoparticles are presented. This will inspire more in-depth research and advance practical applications of metal nanoparticles
in magnetic hyperthermia.
Evaluation and Validation of HF Radar Swell and Wind wave Inversion Method
Authors: Al-Attabi Zaid R. , Voulgaris George , Conley Daniel C.
Published: July 2021

An examination of the applicability and accuracy of the empirical wave inversion method in the presence of swell waves is presented. The ability of the method to invert Doppler spectra to wave directional spectra and bulk wave parameters is investigated using one-month data from a 12 MHz WERA High Frequency (HF) radar system and in-situ data from a wave buoy. Three different swell inversion models are evaluated: LPM (Lipa et al. 1981), WFG (Wang et al. 2016) and EMP, an empirical approach introduced in this study. The swell inversions were carried out using two different scenarios: (1) a single beam from a single radar site and two beams from a single radar site, and (2) two beams from two sites (a single beam per site) intersecting each other at the buoy location. The LPM method utilized using two beams from two different sites was found to provide the best estimations of swell parameters (swell height RMS error 0.24m) and showed a good correlation with the partitioned swell in-situ values. For the wind wave inversion, the empirical method presented here is used with an empirical coefficient of 0.3 which seems to be suitable for universal application for all radar operating frequencies. The inverted swell parameters are used to create a swell spectrum which is combined with the inverted wind wave spectrum to create a full directional wave spectrum. The wave inversion method presented in this study although empirical does not require calibration with in situ data and can be applied to any beam forming system and operating frequency.
Working the urban assemblage: A transnational study of transforming practices
Authors: Durose Catherine , van Ostaijen Mark , van Hulst Merlijn , Escobar Oliver , Agger Annika
Published: July 2021

This article places those working for change in urban neighbourhoods at the centre of debates on urban transformation, directing attention to the importance of human agency in the work of assembling urban transformation. Drawing on cross-national qualitative fieldwork undertaken over 30 months shadowing 40 urban practitioners in neighbourhoods across four European cities – Amsterdam, Birmingham, Copenhagen and Glasgow – our research revealed the catalytic, embodied roles of situated agents in this assembling. Through exemplar vignettes, we present practices in a diverse range of socio-material assemblages aimed to address complex problems and unmet needs in the urban environment. The practices we studied were not those of daily routines, but were instead a purposeful assembling that included nurturing and developing of heterogeneous resources such as relationships, knowledges and materials, framed through an emerging vision to inform, mobilise and channel action. This article brings together assemblage-theoretical and practice-theoretical ideas, with rich empirical insight to advance our understanding of how the city may be re-made.
Extraskeletal Mesenchymal Chondrosarcoma in Nasal Cavity: A Rare Case Report
Authors: Song Chengru , Zhang Yong , Cheng Jingliang
Published: July 2021

Extraskeletal mesenchymal chondrosarcoma (ESMC) originate from the nasal cavity have rarely been reported, especially its imaging features, which makes the preoperative diagnosis difficult. Here, we report the clinical, computed tomography, and magnetic resonance imaging features of a 60-year-old female patient with pathologically confirmed ESMC in the nasal cavity to help provide more reference for diagnosis before operation. Extraskeletal mesenchymal chondrosarcoma in the nasal cavity demonstrates typical imaging features, such as mesh-like enhancement, calcification, hemorrhage, necrosis, cystic degeneration, and so on.
Increased Upper Arm Length and Loading Rate Identified as Potential Risk Factors for Injury in Youth Baseball Pitchers
Authors: Downs Jessica L. , Wasserberger Kyle W. , Barfield Jeff W. , Saper Michael G. , Oliver Gretchen D.
Published: July 2021

Background:

In the throwing elbow, increased elbow torque has been correlated with increased injury risk. Additional insight into the relationships between anthropometric factors and elbow joint loading is warranted.

Purpose:

To investigate the relationship among physical limb length characteristics, elbow kinetics, and elbow kinematics in youth baseball pitchers and to examine the relationship between elbow varus loading rate and elbow kinetics.

Design:

Descriptive laboratory study.

Methods:

A total of 27 male youth baseball pitchers participated (mean ± SD: age, 15.8 ± 2.7 years; height, 176.3 ± 13.0 cm; weight, 71.7 ± 16.4 kg). Upper arm (UA) and forearm (FA) lengths were measured using a moveable sensor to digitize bony landmarks. Kinematic data were collected at 240 Hz using an electromagnetic tracking system. Participants threw 3 fastballs to a catcher at a regulation distance (60 ft 6 in), and the fastest velocity trial was used for analysis. Linear regression was used to determine the relationship among limb length characteristics, elbow kinetics, and elbow kinematics after accounting for the effects of body weight and height.

Results:

Pitchers with longer UA length experienced increased maximum elbow varus torque ( P = .005) and maximum net elbow force ( P = .001). Pitchers with an increased forearm to UA ratio had decreased elbow compression force ( P < .001) and exhibited a more flexed elbow at foot contact ( P = .001). Pitchers with greater maximum loading rates experienced greater elbow varus torque ( P = .002).

Conclusion:

In youth baseball pitchers, longer UA length and greater loading rate increase varus torque about the elbow during a fastball pitch.

Clinical Relevance:

Longer UA length and greater loading rate may place pitchers at risk of injury because of their relationship with kinetic values.
Where, When, and By Whom: An Exploratory Analysis of COVID-19 Public Health Violations
Authors: Leal Wanda E. , Kurland Justin , Piquero Alex R. , Gloyd Elizabeth L. , Leeper Piquero Nicole
Published: July 2021

COVID-19 health restrictions not only affected crime rates but also created a new and temporary type of crime, COVID-19 public health violations. Unfortunately, this new crime type has not yet been empirically scrutinized. The current study is the first to explore these COVID-19 public health violations by using a dataset created by the City of San Antonio which documents all calls and inspections about COVID-19 public health violations. Specifically, this study investigates the location types (where) that produce the greatest number of calls/inspections, warnings, and citations for COVID-19 public health violations; how they trended over time (when); and which agencies responded to and enforced them (who). The results indicate that there were differences across location type, variation throughout the observation period, and violations were enforced by several agencies. It is crucial to document the effect of COVID-19-related policies so that we may be better prepared for the future.
Injuries Associated With Subsequent Child Maltreatment Diagnosis: By Age, Race, Gender, and Medicaid Status
Authors: Negriff Sonya , DiGangi Mercie J. , Sharp Adam L. , Wu Jun
Published: July 2021

This study examined injuries that may precede a child maltreatment (CM) diagnosis, by age, race/ethnicity, gender, and Medicaid status using a retrospective case–control design among child members of a large integrated healthcare system ( N = 9152 participants, n = 4576 case). Injury categories based on diagnosis codes from medical visits were bruising, fractures, lacerations, head injury, burns, falls, and unspecified injury. Results showed that all injury categories were significant predictors of a subsequent CM diagnosis, but only for children < 3 years old. Specifically, fracture and head injury were the highest risk for a subsequent CM diagnosis. All injury types were significant predictors of maltreatment diagnosis for Hispanic children < 3 years, which was not the case for the other race/ethnicities. Overall, these findings suggest that all types of injury within these specific categories should have a more thorough assessment for possible abuse for children under 3 years. This work can inform the development of clinical decision support tools to aid healthcare providers in detecting abusive injuries.
Eight-year follow-up of Artiflex and Artiflex Toric phakic intraocular lens
Authors: Royo Mariano , Jiménez Ángel , Martínez-Alberquilla Irene , Alfonso José F
Published: July 2021

Purpose:

To analyse long-term efficacy, safety, visual and refractive stability and physiological changes of Artiflex Myopia and Toric phakic intraocular lenses (pIOL) separately throughout an 8-year follow-up.

Design:

Retrospective cohort study.

Methods:

A total of 67 eyes of 37 patients underwent Artiflex Myopia (47 eyes) or Artiflex Toric (20 eyes) implantation for correcting myopia and/or astigmatism. Follow-up evaluations were performed 1, 3, 5 and 8 years after surgery. Preoperative and postoperative data included corrected (CDVA) and uncorrected distance visual acuity (UDVA), manifest refraction, endothelial cell density (ECD) and intraocular pressure (IOP) assessments. Efficacy and safety indexes were analysed. The vectorial analysis was performed using the Thibos method.

Results:

Mean CDVA and UDVA of both pIOLs significantly improved from preoperative to 1 year after implantation, and then it remained stable over the 8-year follow-up. The efficacy and safety indexes after 8 years were 0.94 ± 0.16 and 1.07 ± 0.18 for Artiflex Myopia and 1.00 ± 0.11 and 1.10 ± 0.15 for Artiflex Toric, respectively. The spherical equivalent (SE) significantly improved after surgery. J0, J45 and SE refractive components showed no changes between postoperative visits. A total ECD loss of 4.8% ( p < 0.001) and 10.4% ( p = 0.005) was found after 8 years for Artiflex Myopia and Toric, respectively.

Conclusions:

Artiflex Myopia and Toric pIOLs are a safe, efficient and predictable option for the correction of myopia and/or astigmatism. The vectorial analysis showed excellent rotation stability for the toric version.
Outcomes Related to Activity Performance and Participation of Non-Pharmacological Cancer-Related Fatigue Interventions
Authors: Schroder Jodie , Mackenzie Lynette
Published: July 2021

Increased cancer survivorship means more people are living with cancer-related fatigue (CRF), which is associated with activity performance limitations, restricted participation in meaningful life roles, and reduced quality of life. To identify whether non-pharmacological interventions that are effective in minimizing CRF also have an impact on everyday activity performance and participation outcomes for adult cancer survivors. This is a systematic review with narrative synthesis. Eight databases were searched (Medline, CINAHL, PsychINFO, EMBASE, Scopus, OT Seeker, CENTRAL, Cochrane SR database), from 2000 to 2020 for randomized controlled trials of effective non-pharmacological CRF interventions in adult cancer survivors with fatigue. A total of 5,762 studies were identified of which 29 studies were reviewed. In 28 studies, quality of life was investigated as a primary or secondary outcome, where concepts of participation or activity performance were used. Review findings indicate there is insufficient evidence to determine whether activity performance and participation is affected by CRF interventions.
Negotiating Time and Space When Working From Home: Experiences During COVID-19
Authors: Fukumura Yoko E. , Schott Joseph M. , Lucas Gale M. , Becerik-Gerber Burcin , Roll Shawn C.
Published: July 2021

Stay-at-home mandates following the COVID-19 pandemic increased work from home (WFH). While WFH offers many benefits, navigating work in nontraditional contexts can be a challenge. The objective of this study was to explore the benefits and challenges of WFH during COVID-19 to identify supports and resources necessary. Comments from two free-response questions on a survey regarding experiences of WFH ( N = 648, N = 366) were analyzed using inductive qualitative content analysis. Four themes emerged: time use, considerations of working in the home space, intersections between work-life and home-life, and temporality of WFH as situated within a pandemic. Across all themes were concerns related to participation in both work and home roles, work performance, and well-being. Findings highlight the importance of support during times of disruption of occupational patterns, roles, and routines. Despite challenges, many individuals hoped to continue WFH. Organizations should consider the complex intersections of work-life and home-life to develop supportive policies and resources.
Retrospective Analysis of EEG in Patients With COVID-19: EEG Recording in Acute and Follow-up Phases
Authors: Sáez-Landete Isabel , Gómez-Domínguez Adriana , Estrella-León Beatriz , Díaz-Cid Alba , Fedirchyk Olga , Escribano-Muñoz Marta , Pedrera-Mazarro Antonio , Martín-Palomeque Guillermo , Garcia-Ribas Guillermo , Rodríguez-Jorge Fernando , Santos-Pérez Gloria , Lourido-García Daniel , Regidor-BaillyBailliere Ignacio
Published: July 2021

Background. Interest in electroencephalographic (EEG) coronavirus disease 2019 (COVID-19) findings has been growing, especially in the search for a specific-features EEG of encephalopathy. Methods. We made a retrospective analysis of 29 EEGs recorded in 15 patients with COVID-19 and neurological symptoms. We classified the EEGs as “Acute EEG” and “follow-up EEG.” We did a statistical analysis between voltage and respiratory status of the patient, stay or not in the intensive care unit (ICU), days of stay in the ICU, sedative drugs, pharmacological treatment, type of symptoms predominating, and outcome. Results. We found EEG abnormalities in all patients studied. We observed the amplitude of background <20 µV at 93% of “acute EEG,” versus only 21.4% of “follow-up EEG.” The average voltage went from 12.33 ± 5.09 µV in the acute EEGs to 32.8 ± 20.13 µV in the follow-up EEGs. A total of 60% of acute EEGs showed an intermittent focal rhythmic. We have not found a statistically significant association between voltage of acute EEG and nonneurological clinical status (including respiratory) that may interfere with the EEG findings. Conclusions. Nonspecific diffuse slowing EEG pattern in COVID-19 is the most common finding reported, but we found in addition to that, as a distinctive finding, low voltage EEG, that could explain the low prevalence of epileptic activity published in these patients. A metabolic/hypoxic mechanism seems unlikely on the basis of our EEG findings. This pattern in other etiologies is reminiscent of severe encephalopathy states associated with poor prognosis. However, an unreactive low voltage pattern in COVID-19 patients is not necessarily related to poor prognosis.
Using expert judgement techniques to assess reliability for long service-life components: An application to railway wheelsets
Authors: Leite Manuel , Infante Virgínia , Andrade António R.
Published: July 2021

Due to uncertainties in the deterioration process of long service-life assets, assessing reliability and planning maintenance and inspection activities are often difficult tasks. Most of the methods developed use operational or historical data from the manufacturer to predict the deterioration of the asset and estimate its reliability. However, in practice, such failure data is often scarce (e.g. very rare events) and the reliability prediction models might not be adapted to the operation of the user. In addition, available data gathered from maintenance or inspection tasks might only inform about a short period of time, and it might be difficult to obtain the corresponding reliability predictions as the associated uncertainty is still significant. Hence, this paper introduces a reliability assessment method that quantifies uncertainties regarding the failure of long service-life components. It combines Cooke’s classical method (also known as Structured Expert Judgement) with a histogram technique, creating a performance-based method to assess uncertainty in components lifetime distributions. A case study on railway wheelsets is analysed to illustrate the effectiveness of such approach. The results show that the presented method is able to assess failure rates, which can support decisions in reliability-based maintenance of engineering systems.
Is Remote Human Factors Testing an Acceptable Approach for Human Factors Validation
Authors: Kumar Anil R. , Cluff Kevin , McLeroy Tim
Published: July 2021

Human factors (HF) validation of medical devices is vital for approval of use by the Food and Drug Administration (FDA). Historically, validation testing of medical devices has taken place within laboratory-controlled environments where conditions are controlled, and testing is executed in accordance with similar circumstance. Due to the COVID-19 pandemic, laboratory research has decreased in a wide range of disciplines or in instances continued with masks and many other COVID mitigations. As a result, medical device manufacturers who need to provide human factors validation to receive U.S. Food and Drug Administration (FDA) approval were impacted. Remote usability testing, while a fairly new phenomenon for physical devices, affords the ability to functionally test a product within naturalistic environments that are indistinguishable from the settings in which they would be used (e.g. the user’s home). However, published literature to support whether remote HF testing could potentially be an acceptable approach is rare. The objective of this study is to replicate the objectives and structure of an original in-person study, which was conducted using migraine patients who performed one unaided simulated injection using a 2-step autoinjector. The original methodology has been modified to adapt to the remote testing. This paper reports the procedures that has been developed for this ongoing endeavor.
Comparison of three amplicon sequencing approaches to determine staphylococcal populations on human skin
Authors: Ahle Charlotte Marie , Stødkilde-Jørgensen Kristian , Poehlein Anja , Streit Wolfgang R. , Hüpeden Jennifer , Brüggemann Holger
Published: July 2021

Background

Staphylococci are important members of the human skin microbiome. Many staphylococcal species and strains are commensals of the healthy skin microbiota, while few play essential roles in skin diseases such as atopic dermatitis. To study the involvement of staphylococci in health and disease, it is essential to determine staphylococcal populations in skin samples beyond the genus and species level. Culture-independent approaches such as amplicon next-generation sequencing (NGS) are time- and cost-effective options. However, their suitability depends on the power of resolution.

Results

Here we compare three amplicon NGS schemes that rely on different targets within the genes tuf and rpsK, designated tuf1, tuf2 and rpsK schemes. The schemes were tested on mock communities and on human skin samples. To obtain skin samples and build mock communities, skin swab samples of healthy volunteers were taken. In total, 254 staphylococcal strains were isolated and identified to the species level by MALDI-TOF mass spectrometry. A subset of ten strains belonging to different staphylococcal species were genome-sequenced. Two mock communities with nine and eighteen strains, respectively, as well as eight randomly selected skin samples were analysed with the three amplicon NGS methods. Our results imply that all three methods are suitable for species-level determination of staphylococcal populations. However, the novel tuf2-NGS scheme was superior in resolution power. It unambiguously allowed identification of Staphylococcus saccharolyticus and distinguish phylogenetically distinct clusters of Staphylococcus epidermidis.

Conclusions

Powerful amplicon NGS approaches for the detection and relative quantification of staphylococci in human samples exist that can resolve populations to the species and, to some extent, to the subspecies level. Our study highlights strengths, weaknesses and pitfalls of three currently available amplicon NGS approaches to determine staphylococcal populations. Applied to the analysis of healthy and diseased skin, these approaches can be useful to attribute host-beneficial and -detrimental roles to skin-resident staphylococcal species and subspecies.