bluuebunny/crossref_metadata_2025 huggingface dataset:
Engineering Analysis of Non-Braided Polycaprolactone Bioresorbable Flow Diverters for Aneurysms
Authors: Hossan Mohammad Robiul , Barot Vishal , Harriet Seth , Peters Lauren , Matsayko Alex Christopher , Bauer Andrew , Hossain Khalid
Published: July 2023

This paper reports a nonbraided, bioresorbable polycaprolactone (PCL) flow diverter (FD) for the endovascular treatment of aneurysms. Bioresorbable FDs can reduce the risk associated with the permanent metallic FDs as they are resorbed by the body after curing of aneurysms. PCL FDs were designed and fabricated using an in-house hybrid electromelt spinning-fused deposition fabrication unit. Flow diverter's properties, surface qualities, and mechanical characteristics of PCL FDs of 50%, 60%, and 70% porosities were studied using scanning electron microscope (SEM), atomic force microscopy (AFM), and high precision universal testing machine (UTM). The deployability through a clinically relevant catheter was demonstrated in a PDMS aneurysm model. The angiographic visibility of the developed PCL FDs was evaluated using BaSO4 and Bi2O3 coatings of various concentration. The average strut thicknesses were 74.12 ± 6.63 μm, 63.07 ± 1.26 μm, and 56.82 ± 2.09 μm for PCL FDs with 50%, 60%, and 70% porosities, respectively. They average pore areas for the 50%, 60% and 70% porosities FDs were 0.055 ± 0.0056 mm2, 0. 0605 ± 0.0065 mm2, and 0.0712 ± 0.012 mm2, respectively. The surface quality was great with an RMS roughness value of 14.45 nm. The tensile, radial strength, and flexibility were found to be satisfactory and comparable to the nonbraided coronary stents. The developed PCL FDs were highly flexible and demonstrated to be deployable through conventional delivery system as low as 4 Fr catheters in a PDMS aneurysm model. The visibility under X-ray increases with the increasing concentration of coating materials BaSO4 and Bi2O3. The visibility intensity was slightly higher with Bi2O3 coating of PCL FDs. The overall results of the engineering analysis of the developed nonbraided PCL FDs are promising.
Agent-Based Product-Social-Impact-Modeling: A Systematic Literature Review and Modeling Process
Authors: Mabey Christopher S. , Salmon John L. , Mattson Christopher A.
Published: July 2023

A key part of an engineer’s purpose is to create products and services that benefit society, or, in other words, to create products with a positive social impact. While engineers have many predictive models to aid in making design decisions about the functional performance or safety of a product, very few models exist for estimating or planning for the wide range of social impacts an engineered product can have. To model social impact, a model must contain representations of both the product and society. Agent-based modeling is a tool that can model society and incorporate social impact factors. In this paper, we investigate factors that have historically limited the usefulness of product adoption agent-based models and predictive social impact models through a systematic literature review. Common themes of limiting factors are identified, steps are presented to improve the usefulness of agent-based product adoption models and predictive social impact models, and a general process for the creation of agent-based social impact models is presented. Improving the usefulness of these predictive models can aid engineers in making better design decisions. Predictive social impact models can help identify areas in the design space to improve the social impact of products. When coupled with existing design methods, agent-based predictive social impact models can help increase the probability that a product achieves positive social impact.
Interprofessional education in a New Zealand Community Polytechnic: A mixed-method pilot study
Authors: Price Ashleigh Sara , Smith Lee , Gregan Marcella , Le Page Susie , Corlett Reuben , Westenra Belinda
Published: July 2023

INTRODUCTION: Interprofessional collaboration leads to better patient care, enhanced teamwork skills, better communication, and enhanced understandings of each other’s professional roles.
METHODS: The objective of the study was to trial an interprofessional education (IPE) simulation activity with students (nine) from three health and social service disciplines in one community polytechnic. A pre-test/post-test design was used to gather data on the students’ perspectives of the IPE simulation and what the students learned from it. A simple Likert Scale questionnaire and two focus groups (with five and four participants, respectively) were conducted. A thematic analysis of the focus group data was undertaken while survey responses are presented in percentages for ease of readability.
FINDINGS: The participants enjoyed the simulation, had greater confidence with interprofessional communication post-participation and increased knowledge of each other’s scope of practice. The participants welcomed the opportunity to practise handover, which was an area of concern for all.
IMPLICATIONS: IPE is an invaluable tool for preparing students for their future careers as members of an interdisciplinary health team.
Understanding I-Kiribati wellbeing and its implications for health and social services
Authors: Cleverley Louisa
Published: July 2023

INTRODUCTION: Pacific people in Aotearoa New Zealand are a fast-growing population, and research shows that they do not experience the same health benefits others do. While effort has been made to better understand the needs of this population, the results remain largely unchanged. Additionally, practice methods and research to better understand the needs of this group tend to accommodate the more dominant Pacific populations, while less research has gone into understanding the smaller Pacific ethnic populations such as I-Kiribati. This research sought to explore I-Kiribati meanings of wellbeing and how these understandings contribute to creating more culturally appropriate social services.
METHODS: The research employed semi-structured interviews to explore the perspectives and experiences of five I-Kiribati professionals working in health and social services. Recruitment was through purposive sampling.
FINDINGS: The findings outline important aspects that contribute to the wellbeing of both Kiribati and other Pacific groups, factors preventing Pacific minority groups from accessing social services, such as language barriers, acculturation issues, and lack of cultural knowledge and understanding within health, and social services. The findings also suggested the importance of utilising cultural knowledge to inform social work practice, as well as the need for service providers to expand their understanding of the Kiribati culture through more collaboration with Kiribati communities throughout Aotearoa New Zealand.
CONCLUSION: The findings aid further understanding of wellbeing, knowledge on the Kiribati culture and needs of this group, while also informing practice methods for enhanced engagement to best meet the needs of ethnic minority groups.
Fama and French three and six-factor models: Evidence from Indian stock exchange
Authors: Tejesh H. R. , Jeelan Basha V.
Published: July 2023

This study attempts to compare the performance of Fama–French three-factor model (FFTFM) and Fama and French six-factor model (FFSFM) in predicting the variations in expected returns of Nifty-100 listed stocks. Only 5/6 of the total listed companies are chosen, while the remaining 1/6 are ignored because they are not listed for the whole study period. The stocks are divided into two size groups and three groups based on B/M, OP, Inv and MOM using independent sorts to create 24 portfolios. The monthly average returns of the MC-MOM portfolios increase as momentum increases, in contrast to MC-B/M and MC-Inv portfolios. Almost all the portfolios with high returns are paired with significant risk, apart from the BM portfolio in size and profitability group. The findings prove that the FFSFM outperforms FFTFM on all the GRS test parameters. However, there is no significant improvement in explanatory power over the FFTFM.
On the taxonomic status of the tenebrionoid genera Falsopedilus Pic, 1924 and Hintonosia Báguena Corella, 1948 (Coleoptera: Mycteridae) with descriptions of new species
Authors: GOMPEL NICOLAS , TELNOV DMITRY
Published: July 2023

We re-evaluate the taxonomic placement of the genus Hintonosia Báguena Corella, 1948, hitherto placed in Aderidae Csíki, 1909. The assessment of key morphological characters based on the type specimen of the type species of this genus, Hintonosia bismacrocephalus Báguena Corella, 1948 (= Hintonosia macrocephalus Pic, 1935, homonym), demonstrated that it does not possess the synapomorphies of the Aderidae. Instead, its clear position in Mycteridae Blanchard, 1845 is uncovered, leading us to the transfer of Hintonosia to the subfamily Eurypinae Thomson, 1860 of Mycteridae. Moreover, Hintonosia was found congeneric with the mycterid genus Falsopedilus Pic, 1924 and the new synonymy is therefore proposed. Additionally, two African species of Falsopedilus are described, a key to, and a checklist of Falsopedilus species are presented.
A new remarkable species of the genus Hyperlais Marion, 1959 (Lepidoptera: Crambidae) from Kyrgyzstan
Authors: KORB STANISLAV K. , GORBUNOV PAVEL YU. , MELYAKH SERGEY F.
Published: July 2023

A new species, Hyperlais orodruinella sp. n., is described. Its type locality is “Kyrgyzstan, Fergansky Mts., Razan Say Valley, Sary-Bel stream, 41°25’16.74”N, 72°18’59.19”E, 892 m”. This new species differs from all other species of the genus by its patternless wings, by its very dark ground colour and by its male genitalia features, especially aedoeagus cornuti (it has three groups of cornuti instead of two groups in other species).
Looking Back: International Practice Patterns in Breast Radiation Oncology From a Case-Based Survey Across 54 Countries During the First Surge of the COVID-19 Pandemic
Authors: Oladeru Oluwadamilola T. , Dunn Samantha A. , Li Jian , Coles Charlotte E. , Yamauchi Chikako , Chang Jee Suk , Cheng Skye Hung-Chun , Kaidar-Person Orit , Meattini Icro , Ramiah Duvern , Kirby Anna , Hijal Tarek , Marta Gustavo Nader , Poortmans Philip , Isern-Verdum Josep , Zissiadis Yvonne , Offersen Birgitte Vrou , Refaat Tamer , Elsayad Khaled , Hijazi Hussam , Dengina Natalia , Belkacemi Yazid , Luo Feng Deng , Lu Shun , Griffin Colleen , Collins Maya , Ryan Phoebe , Larios Dalia , Warren Laura E. , Punglia Rinaa S. , Wong Julia S. , Spiegel Daphna Y. , Jagsi Reshma , Taghian Alphonse , Bellon Jennifer R. , Ho Alice Y.
Published: July 2023

PURPOSE

The COVID-19 pandemic has profoundly affected cancer care worldwide, including radiation therapy (RT) for breast cancer (BC), because of risk-based resource allocation. We report the evolution of international breast RT practices during the beginning of the pandemic, focusing on differences in treatment recommendations between countries.

MATERIALS AND METHODS

Between July and November 2020, a 58-question survey was distributed to radiation oncologists (ROs) through international professional societies. Changes in RT decision making during the first surge of the pandemic were evaluated across six hypothetical scenarios, including the management of ductal carcinoma in situ (DCIS), early-stage, locally advanced, and metastatic BC. The significance of changes in responses before and during the pandemic was examined using chi-square and McNemar-Bowker tests.

RESULTS

One thousand one hundred three ROs from 54 countries completed the survey. Incomplete responses (254) were excluded from the analysis. Most respondents were from the United States (285), Japan (117), Italy (63), Canada (58), and Brazil (56). Twenty-one percent (230) of respondents reported treating at least one patient with BC who was COVID-19–positive. Approximately 60% of respondents reported no change in treatment recommendation during the pandemic, except for patients with metastatic disease, for which 57.7% (636/1,103; P < .0005) changed their palliative practice. Among respondents who noted a change in their recommendation during the first surge of the pandemic, omitting, delaying, and adopting short-course RT were the most frequent changes, with most transitioning to moderate hypofractionation for DCIS and early-stage BC.

CONCLUSION

Early in the COVID-19 pandemic, significant changes in global RT practice patterns for BC were introduced. The impact of published results from the FAST FORWARD trial supporting ultrahypofractionation likely confounded the interpretation of the pandemic's independent influence on RT delivery.
Digital Platform Regulation: Global Perspectives on Internet Governance, Terry Flew and Fiona R. Martin (eds) (2022)
Authors: Hoskins Guy T.
Published: July 2023

Review of: Digital Platform Regulation: Global Perspectives on Internet Governance, Terry Flew and Fiona R. Martin (eds) (2022)

Cham: Springer International Publishing, 319 pp.,

ISBN 978-3-03095-220-4, e-book, USD 49.99
Religia w leczeniu ran
Authors: Spyrka Kinga , Brela Jakub
Published: July 2023

Istnieje wiele preparatów specjalistycznych służących do pielęgnacji ran, a zawierających składniki, które mogą być sprzeczne z religią pacjentów. Stanowi to wyzwanie w zapewnianiu opieki zdrowotnej w zróżnicowanym kulturowo społeczeństwie. Obecnie nie jest powszechną praktyką informowanie pacjentów o stosowaniu składników pochodzenia zwierzęcego. W pracy omówiono aspekty religijne i kulturowe, o których klinicyści powinni wiedzieć, wybierając specjalistyczne produkty do pielęgnacji ran.
Tiny Snails With Large Distributions: Systematics and Delimitation of the Pacific Land Snails Pacificella and Lamellidea (Stylommatophora: Achatinellidae: Pacificellinae)
Authors: Goulding Tricia C. , Yeung Norine W. , Slapcinsky John , Strong Ellen E. , Kim Jaynee R. , Brook Fred J. , Hayes Kenneth A.
Published: July 2023

The Pacificellinae are a group of small, high-spired land snails distributed on islands across the Pacific. Some species are endemic to particular island groups, but others have wide geographic distributions, several of which have been attributed to anthropogenic transport between islands before western contact. We used DNA sequence data (COI, 16S, ITS2, 28S) from recently collected and historical specimens to estimate a phylogeny of the Pacificellinae, with a focus on Hawaiian species. Phylogenetic analyses support recognizing Lamellidea and Pacificella as distinct genera and indicate that the genus group Tornatellinops should be regarded as a synonym of Lamellidea. The number of taxa defined by species delimitation analyses (ASAP, bPTP, mPTP) varies widely, with between 6 and 42 species estimated in the Hawaiian Islands. These candidate species hypotheses were evaluated in an integrative framework, including shell morphology, geography, and a multilocus phylogeny, to revise the taxonomy of Hawaiian pacificellines. Four Lamellidea species and two Pacificella species are recognized from the Hawaiian Islands, including two widespread species introduced to Hawaiʻi from the South Pacific. Lamellidea peponum in Hawaiʻi shows little genetic divergence from Polynesian specimens previously referred to L. oblonga, and the name L. oblonga is now regarded as a junior synonym. Lamellidea polygnampta is recognized here from across the Hawaiian Islands, L. cylindrica from the island of O‘ahu, and the lowland species, L. extincta, from the main Hawaiian Islands and the Northwestern Islands. The only Pacificella specimens found in Hawai‘i in modern surveys are more closely related to specimens of P. variabilis from Polynesia than to historical specimens of P. baldwini, indicating that the only Pacificella species now found in the main Hawaiian Islands appears to be introduced. Pacificellines have declined in abundance in Hawai‘i over the last century and the two species L. extincta and P. baldwini, formerly present across the Hawaiian Islands, are now either critically endangered or extinct.
Увеличение мышечной массы спортсменов занимающихся силовыми видами спорта
Authors: Рахматов А.И.
Published: July 2023

В данной статье анализируется важный фактор, определяющий силовые качества, которым является величина физиологического поперечника. мышц. Отсюда понятно стремление тренеров планировать тренировочные циклы, направленные на увеличение поперечника и, соответственно, массы мышц спортсменов. При этом в некоторых видах спорта задача увеличения массы мышц может являться самостоятельной, т.е. не связанной с ростом мышечной силы.
Analysis of Farmers' Understanding and Compliance in Paying Agricultural Zakat in Tebedak Village, Ogan Ilir
Authors: Melis Melis , Endraswati Hikmah , Astrid Annisa
Published: July 2023

This article aims to analyze the extent to which farmers in Tebedak Village pay agricultural zakat. The method used in this writing is field research, employing a qualitative approach. The study involved 10 farmers as respondents from Tebedak Village, Ogan Ilir. Data collection techniques included observation, interviews, and documentation. Direct observation was conducted to observe problems and phenomena within the community, particularly among farmers in Tebedak Village, Ogan Ilir District. The study revealed that the majority of farmers in Tebedak Village, Ogan Ilir Regency, had a limited understanding of agricultural zakat due to insufficient knowledge and a lack of socialization from institutions, the government, and village officials regarding various types of zakat maal. Farmers often mistake zakat for infaq and alms, and consider zakat maal as a voluntary act that may or may not be paid. Furthermore, the level of compliance among farmers in paying zakat is not fully satisfactory, as revealed through interviews with the respondents. This can be attributed to their ignorance and lack of awareness about the obligation to pay agricultural zakat.
Investigating the effect of hesperitine on estrogen receptor expression, phosphorylation and activity in MCF-7 cells
Authors: Vosooghi Ramin , Motavalizadehkakhky Alireza , mansouri atena , Mehrzad Jamshid , Homayouni Masood
Published: July 2023

Background
The most typical malignancy among women worldwide is breast cancer. Estrogen receptor play a vital role in this cancer. One of the most known mechanisms that affect the activity of this receptor is its phosphorylation by protein kinase pathways. Studies have shown that hesperetin has an effect on intracellular kinase pathways.
Purpose
The aim of this study was to investigate the effect of hesperetin on the level of expression, phosphorylation and activity of estrogen receptor .
Study design and methods:
MCF-7 cells were cultured in RPMI 1640 phenol red free medium containing charcoal stripped FBS and treated with hesperetin. MTT method was used to evaluate cell survival. The level of ERα protein and its phosphorylated form (Ser118) was determined by western blot technique. Luciferase reporter vector was used to evaluate ERE activity.
Results
The results of this study indicated that hesperetin reduced the survival of MCF-7 cells in a dose dependent manner. The level of expression and phosphorylation (Ser118) of estrogen receptor indicated a significant increase and decrease in the groups treated with hesperetin, respectively. Hesperetin increased the activity of the estrogen receptor in the nonexistence of E2, while in the existence of E2 it caused a significant decrease in receptor activity.
Conclusion
Based on the results of this study, it can be concluded that hesperetin has a significant effect on estrogen receptor expression, phosphorylation and activity probably through protein kinase pathways.
Development and optimization of active edible coatings to improve the shelf life of Indian soft cheese
Authors: Prajapati Priyanka , Garg Meenakshi , Akhtar Saamir , Ansari Tehrir H. , Chopra Rajni , Anand Purnima , Sadhu Susmita Dey
Published: July 2023

The use of active packaging systems that contain antimicrobial agents is considered to be a prudent method of ensuring the quality and safety of food. The purpose of the study was to design an edible coating system to protect Paneer (Indian cottage cheese) using Glycerin, Pectin, and Casein; the coating components were optimized by using the Central Composite Design (CCD) method of Response Surface Methodology (RSM). Different antimicrobial compounds, Copper Nanoparticles (CNP), Eugenol Essential oil (EO), were added to the optimized edible coating to investigate their efficacy by tracking the alteration in phsyico-chemical parameters of Paneer during storage of 14 days. The changes in Paneer were investigated through water distribution, acidity variation, rheological alterations and microbiological analysis during the storage period. Microbe proliferation was reduced by an average of 88.6% when copper nanoparticles were loaded into casein film on the fourteenth day after storage. As a result of the study, a casein-based film containing CNP was able to successfully retain moisture, maintain an optimal pH and ensure the safety and quality of Paneer. Additionally, further research is needed to assess the implication of CNP loaded edible coatings in food packaging as a means to minimize the associated risk associated with CNP consumption.
Sin aliento: el paso de la modernidad
Authors: Bedoya Forno Rodrigo
Published: July 2023

Estrenada en 1960, Sin aliento marca una de las primeras pisadas de la nueva ola francesa, así como el estilo rebelde y vanguardista de Jean-Luc Godard. Influenciado por el neorrealismo italiano, el cineasta rompe con un sinfín de convenciones clásicas del modelo tradicional para dar vida a un cine nuevo y fresco que influenciaría a generaciones hasta el día de hoy.
El proceso creativo como metodología de trabajo del diseñador gráfico
Authors: Cisneros Ríos Rosa Elizabeth , Ramírez Paredes Karina Gabriela , Flores Treviño María Eugenia
Published: July 2023

El proceso creativo acompaña al diseñador gráfico en su día a día, como una herramienta que permite la orientación de la inspiración, habilidades y toma de decisiones, de manera imperceptible al momento de comunicar visualmente algo o resolver una situación laboral. Requiere un dinamismo que complementa un plan de acción el que, al combinar con otros procesos, técnicas o métodos de diseño, optimiza recursos, mejora la calidad, reduce riesgos e incluso puede estandarizar el quehacer de los equipos de trabajo, para mejorar nuestro entorno e incluso facilitarnos la vida. En el presente artículo, a partir de la revisión de las aportaciones de diversos autores, se busca reflexionar sobre la importancia de potencializar el capital intelectual por medio del proceso creativo, empleándolo como una metodología de trabajo y al mismo tiempo para enriquecer la práctica profesional del diseño dentro de los espacios sociales, donde el diseñador gráfico se inserta para brindar sus servicios.
Experiencias de enseñanza-aprendizaje adquiridas en la unidad de aprendizaje Laboratorio de materiales de la licenciatura en Diseño Gráfico
Authors: Rojas Galindo María Bertha
Published: July 2023

La enseñanza en un modelo académico por competencias y centrado en el estudiante, requiere de estrategias y metodologías de enseñanza para que el aprendizaje sea significativo, promoviendo el desarrollo integral de saberes, habilidades y actitudes en los alumnos. En el presente escrito se exponen algunas actividades y evidencias de aprendizaje llevadas a cabo en la unidad de aprendizaje de Laboratorio de materiales, con la finalidad de compartir las experiencias obtenidas en el proceso de enseñanza con alumnos de primer semestre de la licenciatura de diseño gráfico. La práctica educativa incluye identificar los conocimientos previos de los alumnos, respetar los objetivos del plan educativo, la planeación estratégica de las actividades de enseñanza y el diseño de las evidencias de aprendizaje definidos en un programa analítico, modelar las actividades, así como también la evaluación de los productos de aprendizaje para una reflexión que permita la mejora continua del programa y sobre todo de la labor docente.
FREQUENCY OF DIFFERENT WORK RELATED MUSCULOSKELETAL DISORDERS AMONG DENTISTS IN PAKISTAN
Authors: Asma Shakoor  , Aleshba Saba Khan  , Shamima Abdullah  , Hira Shafique  , Yousaf Jamil  , Aleeza Sana
Published: July 2023

Objectives: To determine the frequency of diff erent work related musculoskeletal disorders among dentists.Methods and materials: This cross sectional survey was conducted in diff erent public and private sectors dentistry setups using convenient sampling. In this study the data was collected from 450 dental professionals using NORDIC questionnaire and a structured proforma. Dentist with any history of fractures and surgery were excluded from the study. The data was entered and analyzed using SPSS 25. Chi-square test was used for testing the association between musculoskeletal disorder and diff erent study variable. P-value of 0.05 and less has been considered as significantResults: Among 450 dentists 236(52.4%) were male and 214(47.6%) were female. Mena age of male were 37.08±9.27 whereas mean age of female was33.43±10.42years. Among the dentist 393(87.3%) have musculoskeletal disorder. Among these 393 subjects 388(86.22%) have pain; 124(31.6%) have Mild, 122(31.0%) have moderate and 142(36.1%) have Severe Pain. Pain was found in Hand among 28(6.2%), in Wrist among 52(11.6%), in Fore Arm among 9(2.0%), in Upper Arm among 20(4.4%), in Shoulder among 314(69.8%), in Neck among 210(46.7%), in Upper Back among 20(4.4%), in Middle Back among 163(36.2%) and in Lower Back among 226(50.2%).Conclusion: Overall Shoulder, neck and lower back pain was frequent respectively among dentists but wrist and middle back pain was statistically signifi cantly higher among female. Musculoskeletal disorder aff ects the workability of dentists as well as socioeconomically. Therefore it is suggested that there should be knowledge and practice based workshops should be conducted to address this issue.
Regulation of cellular contractile force, shape and migration of fibroblasts by oncogenes and Histone deacetylase 6
Authors: López-Guajardo Ana , Zafar Azeer , Al Hennawi Khairat , Rossi Valentina , Alrwaili Abdulaziz , Medcalf Jessica D. , Dunning Mark , Nordgren Niklas , Pettersson Torbjörn , Estabrook Ian D. , Hawkins Rhoda J. , Gad Annica K. B.
Published: July 2023

The capacity of cells to adhere to, exert forces upon and migrate through their surrounding environment governs tissue regeneration and cancer metastasis. The role of the physical contractile forces that cells exert in this process, and the underlying molecular mechanisms are not fully understood. We, therefore, aimed to clarify if the extracellular forces that cells exert on their environment and/or the intracellular forces that deform the cell nucleus, and the link between these forces, are defective in transformed and invasive fibroblasts, and to indicate the underlying molecular mechanism of control. Confocal, Epifluorescence and Traction force microscopy, followed by computational analysis, showed an increased maximum contractile force that cells apply on their environment and a decreased intracellular force on the cell nucleus in the invasive fibroblasts, as compared to normal control cells. Loss of HDAC6 activity by tubacin-treatment and siRNA-mediated HDAC6 knockdown also reversed the reduced size and more circular shape and defective migration of the transformed and invasive cells to normal. However, only tubacin-mediated, and not siRNA knockdown reversed the increased force of the invasive cells on their surrounding environment to normal, with no effects on nuclear forces. We observed that the forces on the environment and the nucleus were weakly positively correlated, with the exception of HDAC6 siRNA-treated cells, in which the correlation was weakly negative. The transformed and invasive fibroblasts showed an increased number and smaller cell-matrix adhesions than control, and neither tubacin-treatment, nor HDAC6 knockdown reversed this phenotype to normal, but instead increased it further. This highlights the possibility that the control of contractile force requires separate functions of HDAC6, than the control of cell adhesions, spreading and shape. These data are consistent with the possibility that defective force-transduction from the extracellular environment to the nucleus contributes to metastasis, via a mechanism that depends upon HDAC6. To our knowledge, our findings present the first correlation between the cellular forces that deforms the surrounding environment and the nucleus in fibroblasts, and it expands our understanding of how cells generate contractile forces that contribute to cell invasion and metastasis.
Non-coding RNAs and gastrointestinal cancers prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies
Authors: Zha Bowen , Luo Yuxi , Kamili Muladili , Zha Xiaqin
Published: July 2023

Aim

Provide an overview and a systematic evaluation of the evidence quality on the association between non-coding RNAs (ncRNAs) and prognosis value for gastrointestinal cancers (GICs).

Methods

We searched the literature from three electronic databases: Pubmed, Embase, and Web of science, then carefully screened and extracted the primary information and results from the included articles. We use A measurable systematic review and meta-analysis evaluation tool (AMSTAR2) to evaluate the quality of methodology and then use the Grading of Recommendations Assessment 2, Development and Evaluation guideline (GRADE) make sure the reliability of the meta-analysis.

Results

Overall, 182 meta-analyses from 58 studies were included in this study. Most of these studies are of low or very low quality. Using the scoring tool, we found that only two meta-analyses were rated as high reliability, and 17 meta-analyses were rated as medium reliability.

Conclusions

Although ncRNA has good prognostic value in some studies, only a tiny amount of evidence is highly credible at present. More research is needed in the future.

PROSPERO registration number

CRD42022382296.
Measuring the willingness to share personal health information: a systematic review
Authors: Benevento Marcello , Mandarelli Gabriele , Carravetta Francesco , Ferorelli Davide , Caterino Cristina , Nicolì Simona , Massari Antonella , Solarino Biagio
Published: July 2023

Background

In the age of digitalization and big data, personal health information is a key resource for health care and clinical research. This study aimed to analyze the determinants and describe the measurement of the willingness to disclose personal health information.

Methods

The study conducted a systematic review of articles assessing willingness to share personal health information as a primary or secondary outcome. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis protocol. English and Italian peer-reviewed research articles were included with no restrictions for publication years. Findings were narratively synthesized.

Results

The search strategy found 1,087 papers, 89 of which passed the screening for title and abstract and the full-text assessment.

Conclusion

No validated measurement tool has been developed for willingness to share personal health information. The reviewed papers measured it through surveys, interviews, and questionnaires, which were mutually incomparable. The secondary use of data was the most important determinant of willingness to share, whereas clinical and socioeconomic variables had a slight effect. The main concern discouraging data sharing was privacy, although good data anonymization and the high perceived benefits of sharing may overcome this issue.
A National Perspective on the Current Evaluation Activities in Extension
Authors: Lamm Alexa , Israel Glenn , Diehl David
Published: July 2023

In order to enhance Extension evaluation efforts it is important to understand current practices. The study reported here researched the evaluation behaviors of county-based Extension professionals. Extension professionals from eight states (n = 1,173) responded to a survey regarding their evaluation data collection, analysis, and reporting methods while evaluating their "best" Extension program. The majority used post-tests at the conclusion of their educational activities and reported the actual numbers of respondents. Few respondents collected data representing behavior change. To improve, Extension professionals need to gain evaluation skills and work together to develop strong evaluations that measure change over time.
EMPLOYABILITY SKILLS: PERSPECTIVE FROM EMPLOYERS AND GRADUATES: A QUALITATIVE APPROACH
Authors: Ali Noor Malinjasari , Borhanuddin Rahayu Izwani , Mat Salleh Suzila , Mohamed Nor Raslina , Mohd Noor Hasmida , Kamaruddin Kardina , Mokhlas Hasmi
Published: July 2023

The COVID-19 pandemic has had a tremendous impact on graduates’ employability. With the unemployment rate at 3.3 per cent, this study is viewed from both employers’ and graduates’ perspectives. Therefore, this study has two objectives. First, to examine the factors that contribute to graduates' employability; second, to analyse the quality of graduates from employers' perspectives and the skills they need to possess. The study uses a qualitative approach, and semi-structured interviews were chosen for the data collection process. Second, a focus group discussion was gathered comprising graduates and industry executives to describe the ideal graduate's qualities from employers’ perspectives. The selected ten (10) respondents, seven from various industries as employers and three as graduates or alumni, were interviewed. These finding revealed five criteria that fresh graduates should focus on for employability: academic qualifications and professional certifications; soft skills; working independently; creativity; and networking. The study proposed using quantitative data for future studies.
Optimasi Prediksi Cryptocurrency Menggunakan Pendekatan Deep Learning
Authors: Nurhaida Ida , Sobiri Mochamad , Jaya Safitri
Published: July 2023

Cryptocurrency adalah mata uang digital terdesentralisasi yang diatur oleh pemerintah pusat. Karena cryptocurrency sangat fluktuatif, analisis diperlukan  sebelum menggunakan cryptocurrency untuk meminimalkan kerugian. Penelitian ini melakukan perbandingan antara model Long Short Term Memory (LSTM) dan algoritma optimasi seperti Adam dan Root Mean Square Propagation (RMSProp) untuk melakukan prediksi terhadap nilai cryptocurrency. Metode LSTM dioptimasi menggunakan Adam Optimizer dan dievaluasi berdasarkan Root Mean Square Error (RMSE). Dengan demikian diperoleh prediksi nilai RMSE sebesar  0.08217562639465784 yang merupakan nilai error yang kecil sehingga mendekati nilai aktual. Sedangkan nilai RMSE 0.10699215580552895 menggunakan RMSProp mendapatkan nilai yang lebih besar yang berdampak terhadap akurasi hasil prediksi. Dengan demikian kombinasi antara algoritma LSTM dan Adam dapat melakukan prediksi dan mengoptimasi data dengan akurat.
PENGENALAN MAKANAN SEHAT DAN ZAT ADITIF BERBAHAYA BAGI SISWA/I MAN 2 PADANG
Authors: S Vivi Syofia , Firdaus  , Zulham Efendi  , Farida Ariyani
Published: July 2023

Latar Belakang : Keberadaan makanan jajanan yang menampilkan warna menarik dan rasa yang lezat memberi kesempatan pada siswa/I MAN 2 Padang untuk memilih membeli makanan jajanan disekolah daripada membawa makanan bekal yang disiapkan oleh ibu mereka dari rumah. Apabila dilihat dari segi penampilan makanan jajanan tersebut memungkinkan diberikan keberadaan zat aditif seperti pengawet, pewarna dan penguat rasa yang berlebihan yang bisa memberikan dampak buruk terhadap kesehatan para siswa tersebut. Oleh karena itu, kami dari dosen STIKes Mercubaktijaya Padang berkeinginan untuk mengadakan kegiatan pengabdian berupa pengenalan makanan sehat dan zat aditif berbahaya bagi siswa/I MAN 2 Padang dengan harapan, para siswa tersebut bisa lebih selektif dan cerdas dalam memilih makanan jajanan yang akan mereka konsumsi.   Kegiatan pengabdian dilakukan dengan metode ceramah menggunakan media pembelajaran powerpoint, dengan memasukkan jenis-jenis makanan diperkirakan mengandung zat aditif yang berlebih. Hasil angket awal ditemukan bahwa sekitar 20% siswa belum mengetahui dan memahami keberadaan zat aditif berlebih dan membahayakan bagi siswa tersebut. Para siswa memilih makanan jajanan yang dibeli melihat dari warna makanan menarik dan rasa yang lezat. Setelah dilakukan presentasi pengenalan makanan sehat dan zat aditif berbahaya, para siswa tersebut telah menyadari bahwa kebiasaan membawa bekal dari rumah lebih baik daripada membeli makanan jajanan disekolah demi menjaga kesehatan mereka.
Improved breast ultrasound tumor classification using dual-input CNN with GAP-guided attention loss
Authors: Zou Xiao , Zhai Jintao , Qian Shengyou , Li Ang , Tian Feng , Cao Xiaofei , Wang Runmin
Published: July 2023

Ultrasonography is a widely used medical imaging technique for detecting breast cancer. While manual diagnostic methods are subject to variability and time-consuming, computer-aided diagnostic (CAD) methods have proven to be more efficient. However, current CAD approaches neglect the impact of noise and artifacts on the accuracy of image analysis. To enhance the precision of breast ultrasound image analysis for identifying tissues, organs and lesions, we propose a novel approach for improved tumor classification through a dual-input model and global average pooling (GAP)-guided attention loss function. Our approach leverages a convolutional neural network with transformer architecture and modifies the single-input model for dual-input. This technique employs a fusion module and GAP operation-guided attention loss function simultaneously to supervise the extraction of effective features from the target region and mitigate the effect of information loss or redundancy on misclassification. Our proposed method has three key features: (i) ResNet and MobileViT are combined to enhance local and global information extraction. In addition, a dual-input channel is designed to include both attention images and original breast ultrasound images, mitigating the impact of noise and artifacts in ultrasound images. (ii) A fusion module and GAP operation-guided attention loss function are proposed to improve the fusion of dual-channel feature information, as well as supervise and constrain the weight of the attention mechanism on the fused focus region. (iii) Using the collected uterine fibroid ultrasound dataset to train ResNet18 and load the pre-trained weights, our experiments on the BUSI and BUSC public datasets demonstrate that the proposed method outperforms some state-of-the-art methods. The code will be publicly released at https://github.com/425877/Improved-Breast-Ultrasound-Tumor-Classification.
PENGUKURAN KEEFEKTIFAN MESIN LOHIA 1 MENGGUNAKAN METODE TOTAL PRODUCTIVE MAINTENANCE (TPM) DI PT. KERTA RAJASA RAYA, PLANT MOJOSARI
Authors: Sari Erlin Kurnia , Herlina Herlina
Published: July 2023

PT. Kerta Rajasa Raya is a manufacturing company engaged in the plastic sack manufacturing industry. The company uses Lohia 1 machines (Lohia 1 Extruder and Winder Machines) in producing semi-finished products, namely plastic yarn as the main ingredient for making plastic sacks. This Lohia 1 engine has different types of defects, which causes defects and production results that are not on target. Overall Equipment Effectiveness (OEE) is a measurement method to determine the extent of performance, as well as the quality of a machine or equipment. OEE is known as one of the implementations of Total Productive Maintenance (TPM). Measuring the level of performance effectiveness of the Lohia 1 engine at PT. Kerta Rajasa Raya in the period February 2022 to March 2022 the results obtained were somewhat inadequate according to the JIPM (Japan Institute Of Plant Maintenance) standard with a standard of 85%, while the effectiveness of the Lohia 1 engine, namely for February 2022 was 23% and March 2022 by 33%. So, the OEE percentage value is still below 85%
The neuropsychomotor impact of capoeira on people with intellectual disabilities: a case study
Authors: Rocha Paulo , Pereira Antonino , Simim Mário , Aranha Ágata
Published: July 2023

Due to the advances made in terms of socio-educational inclusion, we seek to understand better strategies for the development of people with intellectual and developmental disabilities (IDD). Objective: To identify the neuropsychomotor impact that a capoeira intervention promotes in people with intellectual and developmental disability (IDD). Methods: case study, with an exploratory qualitative approach. The study site was the Pestalozzi Association in Fortaleza, Ceará – Brazil. 10 students with IDD. A semi-structured interview was applied with parents, teachers and professionals who accompanied the research participants. The interviews were analyzed using Bardin's (2015) content analysis and followed the following categories: motricity, psychological aspects, social aspects, and school learning. The impacts were observed in the social, psychological, and psychomotor aspects according to the parents, teachers and professionals interviewed. Conclusion: We conclude that an intervention program with capoeira for people with IDD promotes positive changes in neuropsychomotor aspects.
MOSTRUÁRIO DE SEMENTES DE PLANTAS DANINHAS PARA PADRONIZAÇÃO DE ANÁLISE DE SEMENTES EM LABORATÓRIO CERTIFICADO PELO MAPA
Authors: Pedroso Francisco de Assis , Quisbert Jonas Guarachi , Dourado Camila da Silva , Fernandes Liliane Menezes
Published: July 2023

O objetivo desse trabalho foi montar e apresentar um mostruário com 130 espécies de plantas daninhas, embasada cientifica e legalmente, para que laboratórios que o utilizar possa ter segurança em analisar as diversas sementes de cultura que se submeter a sua observação. Plantas daninhas são fatores limitantes na produção agrícola, pois interfere na qualidade e pode trazer no seu microclima patógenos além de insetos e outras pragas que irão comprometer o resultado final da lavoura.  Desta forma é importantíssimo que se este fator não pode ser bloqueado de forma total, deve ser então controlado da melhor forma possível, e uma forma bastante eficiente e inteligente é conseguir analisá-lo na fonte, ou seja, nas análises laboratoriais das sementes. As sementes de cultura, quando na sua produção, não tem o controle eficiente das plantas daninhas, contaminam as sementes que serão comercializadas e enviadas a inúmeras localidades para outros municípios, estados e as vezes até para outros países. Sendo assim é muito importante que seja controlada todo essas análises, através de leis e rigorosa fiscalização governamental. Por outro lado, as empresas de análises laboratoriais de sementes precisam ter parâmetros para poder analisar de forma eficiente e poder atingir os índices a altura da fiscalização vigente, bem como conseguir estar no nível de excelência como o patamar que a agricultura brasileira conseguiu atingir no cenário internacional de produção agrícola. Entre tantos equipamentos e metodologias descrita em leis que os órgãos fiscalizatórios utilizam, encontra-se o mostruário de sementes de espécies nocivas toleradas e proibidas.
PENGARUH FRAUD PENTAGON TERHADAP PERILAKU KECURANGAN AKADEMIK
Authors: Alfian Nurull , Rahayu Runik Puji , Rahayu Runik Puji
Published: July 2023

The purpose of this study was to determine the effect of the fraud pentagon on academic fraud behavior. Collecting data in this study was carried out with a quantitative type of research by distributing questionnaires to 100 (one hundred) students. The data analysis method used is using multiple linear regression analysis. The results showed that the fraud pentagon had a positive and significant effect on academic fraud behavior. Partially there is a positive and significant effect of pressure on academic cheating behavior, there is an insignificant effect of opportunity on academic cheating behavior, there is an insignificant effect of rationalization on academic cheating behavior, there is a positive and significant effect on the ability of academic cheating behavior and there is positive and significant influence of ethics on academic deficiency behavior.
SISTEM PENGENDALIAN INTERNAL PENERIMAAN DAN PENGELUARAN KAS PADA BIRO ADMISI DAN PEMASARAN
Authors: Sahara Meliana , Farina Khoirina
Published: July 2023

This research to find out how to implement the internal control system for cash receipts and disbursements, to evaluate the internal control system for cash receipts and disbursements and to compare the internal control systems for cash receipts and disbursements at the Admissions and Marketing Bureau with the internal control system for cash receipts and disbursements according to the Committee of Sponsoring theory. Organization Of Treadway Commission.The type of data used in this study is qualitative data, where the data used in this study are primary data and secondary data. The research method used in collecting data in this study is the field research method. While the analysis method used in this research is descriptive analysis method.The results of this study can be concluded by the authors, that the implementation of internal control of cash receipts and disbursements at the Admissions and Marketing Bureau is considered not optimal with the components of the internal control system according to the Committee Of Sponsoring Organization Of Treadway Commission, so that the system of cash receipts and disbursements must be arranged in detail. to support the implementation of cash receipts and disbursements in a more orderly, integrated, effective and efficient manner.Keywords: Internal Control System, Cash Receipts, Cash Disbursements.
WHISTLEBLOWING, KPK INDONESIA DAN CPIB SINGAPURA
Authors: Arismaya Anisa Dewi
Published: July 2023

Whistleblowing is one of the tools used by anti-corruption agencies in Singapore and Indonesia to support the prevention and implementation of an anti-corruption culture. The implementation of Whistleblowing in Indonesia and Singapore has complied with the standard of application, but there are several things that are still obstacles to implementation, including the absence of a law that guarantees the confidentiality of the reporter. This study uses a qualitative descriptive analysis method to explain the differences in the application of Whistleblowing at the KPK and CPIB Singapore corruption eradication institutions. From the results of the study, it can be concluded that CPIB Singapore applies Whistleblowing with complete content and independent application because it has a centralized structure while at the Corruption Eradication Commission, the application of Whistleblowing is not centralized because it is derived from central government institutions and local governments.
PENGARUH PERSEPSI KARYAWAN MENGENAI WHISTLEBLOWING SYSTEM TERHADAP PENCEGAHAN FRAUD DENGAN PERILAKU ETIS SEBAGAI VARIABEL INTERVENING
Authors: Alfian Nurul , Sugiyardi Agus , Aina Muslimatul , Kusuma Andriyani , Fajar Achmarul , Rizal Zef
Published: July 2023

This study aims to determine: (1) Effect of Employee Perception Regarding Whistleblowing System on Fraud Prevention, (2) Effect of Employee Perception Regarding Whistleblowing System on Ethical Behavior, (3) Effect of Ethical Behavior on Fraud Prevention, (4) Effect of Employee Perception Regarding Whistleblowing System for Fraud Prevention through Ethical Behavior. This research is a type of comparative causal research. The population of this research is all employees who work. Sampling was done by using purposive sampling technique. The sample in this study were all employees of the Office of the Board of Directors of PT Pagilaran. Before the research was conducted, the instrument was tested first involving 30 employees. The analytical prerequisite test tools used in this research are normality test, linearity test and heteroscedasticity test. The data analysis method used to test the research hypothesis is path analysis and Sobel Test. The results of the hypothesis test show: (1) Employee Perception Regarding Whistleblowing System has a significant positive effect on Fraud Prevention, this is evidenced by the significance probability value of 0.004 (< t table (2.042).