bluuebunny/crossref_metadata_2025 huggingface dataset:
Data Firme: La revolución mediática en la periferia amazónica
Authors: Cavalcante Acilon
Published: June 2022

Data Firme es un proyecto comunitario y colaborativo en Terra Firme, un barrio de producción informal de Belém, la ciudad más antigua del Amazonas brasileño y con un número significativo de personas que viven en asentamientos precarios para los estándares brasileños. Este barrio es el resultado del proceso de urbanización en el Amazonas, que atrajo a migrantes del noreste brasileño en las décadas de 1980 y 1990 y produjo uno de los asentamientos informales más peculiares de las zonas urbanas. A pesar de los diversos problemas que enfrentan, desde la violencia urbana hasta la falta de una estructura de saneamiento básico, la comunidad tiene hoy un profundo sentido de pertenencia al lugar, cambiando su capital social actual a formas participativas de compromiso cívico. El proyecto tuvo lugar entre 2018 y 2020, con el objetivo de extraer datos de las afueras del distrito y compartirlos a través de medios digitales como productos audiovisuales, memes e infografías. Data Firme desarrolló una relación entre la Universidade Federal do Pará y los grupos cívicos, utilizando plataformas digitales en el barrio para lograrlo. Estos grupos iniciaron sus actividades participativas en 2014, luego de un acto de matanza que se cobró 14 vidas y sembró el terror entre los pobres que viven en las periferias de Belém. Juntos lanzaron protestas contra la violencia urbana y utilizaron plataformas digitales para organizarse en busca de derechos sociales y mostrar el interior de su barrio. Algunos grupos utilizan la cultura en los medios digitales para involucrar a las personas en los instrumentos de control social, la gobernanza urbana y la violencia policial entre los movimientos cívicos participativos. En 2018, el lanzamiento del proyecto Data Firme se acercó a esos grupos para caracterizar sus actividades y utilizar metodologías colaborativas para desarrollar datos y contenidos según su perspectiva. El proyecto duró más de tres años, teniendo como objetivos el empoderamiento digital de la comunidad juvenil de Terra Firme, la extracción y desarrollo de datos sobre sus vidas y la producción de contenidos. Como resultado, Data Firme: 1. Ayudó a impulsar la presencia digital de esas comunidades en las redes sociales; 2. Produjo siete episodios de documentales web que exploran la historia del barrio; y 3. Desarrolló cartografía social generando datos en diferentes estratos geográficos y sociales. El trabajo de esos grupos cívicos participativos tiene un impacto profundo en el vecindario al cambiar el marco mediático que la corriente principal produce sobre la comunidad y al desarrollar modelos de gobernanza con vínculos inferiores con los agentes del gobierno local. todas cuestiones que parecían imposibles hace solo una década. En este documento, nuestro objetivo es contar esta historia y cómo los enfoques colaborativos pueden marcar una diferencia en la vida de las comunidades pobres en una metrópoli amazónica
Tornando-se meio ambiente_tornando-se pós-animista: A vida é uma utopia
Authors: Tsuda Carlos Eduardo
Published: June 2022

Neste artigo, apresento estudos de caso das intervenções urbanas, instalações e performances para o espaço público da minha série de arte intitulada “A vida é uma Utopia”. “Life is an Utopia” é uma pesquisa artística e uma série de obras de arte que visa discutir questões sociais-políticas-ambientais-culturais contemporâneas por meio de uma perspectiva estética e práticas poéticas. Propõe um exercício crítico de cruzamento de fronteiras entre arte sonora, performance audiovisual, performance, instalação e intervenção urbana, que questiona a crescente desvalorização da vida face ao mercado financeiro, manifestada nas recentes catástrofes ambientais e no desmantelamento sistemático dos direitos sociais e humanos no Brasil. A partir de proposições de contraposição entre o embotamento e o contemplativo, na série a artista explora o termo cultural japonês “Ma” como uma abertura ao ambiente, a tudo que nos rodeia e não controlamos, propondo uma visão crítica do sistema através de uma perspectiva resiliente. À luz de autores de diferentes modalidades disciplinares, pratico a investigação interdisciplinar e descentralizada, hibridizando diferentes formas de produção de conhecimento através do diálogo entre a investigação teórica e a prática artística. Apresento os conceitos de tornar-se meio ambiente e tornar-se pós-animista como formas de montagens poéticas e estéticas da vida pública e suas inúmeras implicações sócio-político-ambientais na relação entre humanidade e Natureza, sociedade e espiritualidade, corpo e alma e comunidade, espiritualidade e Natureza. Com base no conceito de pós-animismo ou animismo pós-moderno, do sociólogo japonês Shoko Yoneyama, e nas perspectivas cosmológicas e animistas dos intelectuais indígenas brasileiros Ailton Krenak e Davi Kopenawa, pretendo problematizar etapas do processo criativo das obras e sua relação com a vida pública, no que diz respeito às formas de interação e participação pública, às mudanças perceptivas do espectador e à transformação das estruturas de relacionamento e estratos sociais estabelecidos no espaço. Num sentido macro, abordarei as inúmeras modalidades do experimentalismo sócio-político-artístico e do silêncio como forma de resistência e resiliência política. Neste contexto, processos criativos envolvendo a construção de redes de interatividade, a criação de redes de ativação temporária, o desenvolvimento e promoção de processos de negociação de curto, médio e longo prazos, o desenvolvimento de processos de subversão, hacking, infiltração e contaminação, a criação de sensações e distorções temporais e espaciais, e as transformações afetivas das relações interpessoais e sociais.
A Lua gira e devemos girar com ela: Te Maramataka como instalação de arte interativa
Authors: Citizen Joe
Published: June 2022

Colaborações interculturais entre Te Ao Māori e Te Ao Pākehā são notoriamente difíceis para todos os envolvidos. O que o conhecimento é e não é, quem ou o que tem ação no mundo, como e quando as coisas acontecem e a natureza dos próprios relacionamentos estão situados em diferentes visões de mundo culturalmente informadas. Tentar fazer um repositório de conhecimento sobre Te Maramataka (calendário lunar) por meio de uma arte interativa imersiva significa envolver-se com duas estruturas de conhecimento distintamente diferentes, mas igualmente válidas, e sua metafísica fundamental associada. Navegar entre e através dessas estruturas de conhecimento é participar de abordagens especulativas e baseadas na prática, que promovem fenômenos emergentes relacionalmente. É por meio da colaboração no hífen intercultural que entramos deliberadamente no espaço da inovação, ao mesmo tempo que tentamos estar atentos à preservação do mana dos especialistas existentes. No momento, representamos uma parceria entre Te Rūnanga o Kirikiriroa e Wintec rangahau e profissionais de pesquisa em artes criativas, cada um com suas próprias responsabilidades informadas institucionalmente. Ao nos reconhecermos como um rōpū (grupo) coletivo que embarca em um empreendimento compartilhado, podemos enfatizar o processo de aprendizado sobre nosso whanaungatanga compartilhado (relacionamentos interconectados), a fim de buscar acordos mutuamente aceitáveis baseados no útil. Esta ênfase no processo é crítica e deve levar seu próprio tempo, especialmente quando Te Maramataka enfatiza as influências das fases da Lua girando em nós mesmos, bem como em tudo o mais que também já está acontecendo. Reconhecer esta relacionalidade entre as coisas significa admitir que o conhecimento, em si, é experiencial, corporificado e performativo: como “chegamos lá” é parte do próprio destino “lá”. No contexto de decidir quais tecnologias digitais empregar na confecção de uma instalação de arte interativa, os entendimentos contemporâneos do que é arte, como o significado é feito e compreendido e quem ou o que tem agência dentro do campo de relações circundante, são desestabilizados. Em nosso empreendimento conduzido pela prática, girar com a Lua significa reconhecer as tensões dinâmicas que existem entre tradição com inovação, representação com aprendizagem experiencial e o cognoscível com o oculto, misterioso e, em última análise, incognoscível. Quer estejamos falando sobre reivindicações baseadas em regras de indicialidade vis-à-vis gêmeos digitais informados por estruturas cognitivistas de lógicas operacionais ou paradigmas de reconhecimento de padrões / IA abertos sem estado, estes devem ser equilibrados com o conhecimento existente de especialistas em Maramataka Maori e seu conhecimento vivo e incorporado.
Influence of vegetable powders obtained from products of processing fruit and vegetable raw materials on technological properties of minced fish
Authors: Mosharova Margarita Eduardovna , Titova Inna Markovna
Published: June 2022

The influence of vegetable powders obtained from pomace (secondary raw materials in the production of directly squeezed juices) on the technological properties of minced pollock, cod and Baltic herring has been proved. Experimental data obtained indicate the increased water-retaining capacity of minced fish. The water-retaining capacity of minced cod and pollock meat increases by 14-15 units, when apple and carrot powders are added; when powder from berries is added, it increases by 8-9 units. The water-retaining capacity of minced herring meat with adding the apple and carrot powders increases by 11-12 units; with adding the berry powder it increases by 8.3 units. The change in the index of water-holding capacity of minced fish with the addition of vegetable powders in the process of refrigeration was studied. It was found that after defrosting, the water-retaining indicator of control samples of minced fish decreased by an average of 3.2-3.5 units, while the decrease in this indicator for minced meat with adding the vegetable powders does not exceed 1.4 units. Minced meat with adding the apple powder is most resistant to changes in the state of moisture aggregation. It has been found that introducing 10% of the vegetable powders into the minced meat can reduce losses under heat treatment when bringing the products to culinary readiness compared to the control sample: apple and carrot powders - by 15-20%, berry powder - by 8-10%. The effect of vegetable powders on the water activity index in minced fish was studied. Due to introducing the vegetable powders into the minced meat the water activity indicator is found to decrease compared to the control sample: apple and carrot powders - by 0.5%, berry powder - by 0.2%.
Characteristics of growing different ecological forms of whitefish in Topo-Pyaozero Reservoir (White Sea catchment) at present
Authors: Georgiev Andrey Pavlovich , Cherepanova Nadezhda Stepanovna , Shirokov Vyacheslav Anatolievich
Published: June 2022

In northern freshwater ecosystems whitefish is a valuable commercial species. Their decreasing stocks are caused by the human economic activity. Complexity of the ichthyofauna of northern ecosystems is explained not only by the number of species, but also by the abundance of various ecological forms. On the whole, in the Topo-Pyaozero Reservoir, the division of whitefish according to forms was not practiced even in the years of developed fishing with significant catches, and at present most fish producers do not distinguish between these forms. The ratios of different forms of whitefish in catches are relatively stable, but their biological parameters are of interest, if the question arises about the dominance of individual forms of whitefish during the long-term exploitation of their commercial stocks. The aim of the study was to consider the biology of different forms of whitefish in the Topo-Pyaozero Reservoir (the Republic of Karelia). Whitefish is the only limiting object of fishing in the Reservoir. By morphological and ecological features there are distinguished 6 forms of whitefish: 2 lacustrine (at least 50% of the catch) - coastal and deep-water (lattaneni), and 4 anadromous (leaf fall (lehtisiiga), kukkaneni, kutcheri, suurisiga). All forms can be found on both the Pyaozero and Topozero reaches of the Reservoir. In the light of the materials given on the features of all forms of whitefish caught in the Topo-Pyaozero Reservoir, it is clear that a biologically justified catch size will correspond to a minimum size of whitefish - 26 cm. These data will encourage more abundant catches of whitefish, which corresponds to the current Fishing Rules for Northern reservoirs of Russia
Technology and quality of phyto-candies from Japanese kelp
Authors: Dement'eva Natal'ya , Boytsova Tatiana
Published: June 2022

The developed technology of producing phyto-candies from Japanese kelp provides the high organoleptic characteristics, nutritional and biological values of the products. The phyto-candy formulations contain 60% kelp, 14% honey, dried fruits (apricots, prunes, dates, mangoes). Preliminary kelp heat treatment, including threefold short-term kelp boiling sessions at 85-95 °C, provides a dense but not rigid kelp structure. Adding 2% of citric acid at the second boiling session helps to remove the pronounced taste and smell of algae. Under processing kelp slightly loses moisture. It has been found that fresh kelp contains 94.5% of water before treatment; after treatment the amount

of water in it is 90.6-91.3%. In pretreatment kelp slightly loses the mineral substances, the amount of which after processing makes 1.31%. Under heat treatment the amount of mannitol in luminaria decreases almost twice, nevertheless 7.74% of mannitol remains. Adding a citric acid to the boiling water during kelp processing causes the increase

of alginic acids in it. In the fresh kelp the alginic acid content was 27.44%, and after processing - 33.87%. The relative biological value of phyto-candies produced from Japanese kelp varies within 70.8-78.2% depending on the formulation. The maximum increase in Tetrahymena pyriformis infusoria and a higher relative biological value were observed in phyto-candies prepared according to the formulations including dried apricots and prunes. When storing phyto-sweets from Japanese kelp at 0-6 °C and humidity of 75% during 9 months, the number of mesophilic aerobic and facultative anaerobic microorganisms did not exceed the maximum permissible norms and varied within 0.1 ∙ 101 CFU/g at the beginning of storage - 4.9 ∙ 104 CFU/g at the end of the storage period. Bacteria of the E. coli group, S. aureus, mold, or yeast were not detected.
Fish puddings for young schoolchildren
Authors: Tsibizova Maria Evgenievna
Published: June 2022

Proper nutrition ensures the normal physical development of a person, regardless of age, prevents the devel-opment and growth deviations, helps to increase the resistance of the child's body to infectious diseases and combats alimentary-dependent diseases. There has been studied the possibility of expanding the assortment of fish puddings by modifying their recipes and including them in the diet of primary school children. This goal was achieved by using fish raw materials with lean protein and medium-fat protein, which was considered as an interchangeable fish raw material. Experimental studies were carried out to substantiate prescription compositions of puddings without adding bread previously soaked in milk, but including a structure-forming component from fish bone tissue (heads, ridge and fins) in their composition. The comparative analysis of organoleptic and physicochemical indices of quality, chemical composition and energy value of the obtained products has been carried out. It has been found that puddings based on silver carp or pike perch meat can be attractive for young school children. The part of the structure-forming component should not exceed 14%. For mass nutrition of primary school children there are recommended the puddings produced according to recipes No. 1.2 and 1.3, which include silver carp or pike perch meat (74%), structure-forming component (14%), unsalted butter (4%), raw egg (7.0%) and flavorings. The ratio of these components ensures developing high organoleptic properties and increased nutritional value of the product. Including the fish puddings in the diet of young school children allows balancing their diet in terms of proteins, fats, amino acids, correct their eating behavior and increase the attractiveness of the fish product for the young group of the population of Russia.
SOSIALISASI PEMBUATAN TEH HERBAL DALAM KEMASAN TEH CELUP PADA KELOMPOK PKK KALABBIRANG, KABUPATEN TAKALAR
Authors: Santi Irma , Amirah Sitti , Andriani Irma
Published: June 2022

Masyarakat luas kurang meminati teh herbal karena kurangnya pengetahuan terutama tentang khasiatnya, cara pengolahan yang tepat, adanya aroma dan rasa pahit atau hambar (tidak berasa) yang biasa muncul dari teh herbal serta kemasan yang kurang praktis dan menarik. Kegiatan pengabdiaan bertujuan untuk memberikan pengetahuan dan keterampilan kepada masyarakat terkait pembuatan teh celup kemasan dari tanaman herbal yang memiliki cita rasa aroma yang nikmat. Pada kegiatan pengabdiaan ini, dilakukan metode yaitu penyuluhan dan pelatihan pembuatan teh herbal pada anggota kelompok pembinaan kesejahteraan keluarga (PKK) dengan membuat teh herbal kombinasi daun pegagan (Centella asiatica) dan kayu secang (Caesalpinia sappan L) dengan penambahan pemanis daun stevia (Stevia rebaudiana) serta evaluasi kegiatan. Hasil kegiatan pengabdiaan ini menujukkan tingkat pengetahuan peserta meningkat dari tingkat pengetahuan kurang (46,66 %) menjadi tingkat pengetahuan baik (80%). ini berdasarkan pertanyaan yang diberikan kepada peserta kegiatan. mengenai khasiat,cara yang tepat dalam proses pemetikan, pengolahan tanaman herbal menjadi simplisia hingga cara pembuatan teh herbal dalam bentuk kemasan teh celup yang sebelumnya mereka belum ketahui dengan baik.
INTENSIFIKASI BUDIDAYA PAKAN ALAMI SEBAGAI PENUNJANG PENINGKATAN PRODUKSI BENIH IKAN TAGIH (Mystus nemurus C.V.)
Authors: Andriani Yuli
Published: June 2022

Kegiatan penyuluhan ini telah dilaksanakan di Kelompok UPR Karper Mina, Kecamatan Tanjungkerta Kabupaten Sumedang, Jawa Barat, bertujuan untuk memberikan pengetahuan serta keterampilan dalam membudidayakan pakan alami Chlorella dan Artemia sebagai salah satu jenis pakan alami untuk benih ikan. Metode yang dilakukan pada program ini meliputi : survei dan observasi lapangan, sosialisasi, penyuluhan, pembuatan media budidaya pakan lami, budidaya pakan alami dan pendampingan. Penyediaan pakan alami untuk kegiatan budidaya benih ikan selama ini dilaksanakan dengan cara menangkap dari alam, sehingga pembudidaya sebaiknya memiliki kemampuan berbudidaya secara mandiri untuk menjada kuantitas dan kualitas pakan alami. Hasil survei dan observasi lapangan menunjukkan terdapat potensi sumber pakan alami serta sumber daya manusia yang dapat dioptimalisasikan untuk mendukung kegiatan perikanan diantaranya budidaya pakan alami untuk meningkatkan produksi benih ikan. Kelompok masyarakat yang menjadi sasaran terdiri para pembenih ikan yang tergabung dalam Kelompok UPR Karper Mina. Tahap pertama yaitu penyuluhan mengenai potensi dan peran penting pakan alami dalam kegiatan pembenihan ikan. Setelah dilakukan penyuluhan tentang jenis-jenis pakan alami dan media yang digunakan untuk budidaya selanjutnya dilakukan praktek budidaya pakan alami jenis Chlorella dan Artemia. Hasil dari kegiatan ini adalah masyarakat memahami urgensi pakan alami untuk pertumbuhan benih ikan, megetahui jenis-jenis pakan alami dan dapat membudidayakan pakan alami secara mandiri.
PEMANFAATAN PUPUK ORGANIK CAIR DARI LIMBAH PERTANIAN UNTUK MENINGKATKAN HASIL TANAMAN SAYURAN DI DESA CILELES, JATINANGOR, KABUPATEN SUMEDANG
Authors: Setiawati Mieke Rochimi
Published: June 2022

Desa Cileles merupakan salah satu desa di Kecamatan Jatinangor yang memiliki area pertanian yang luas dengan mayoritas masyarakatnya berprofesi sebagai petani. Penggunaan pupuk untuk meningkatkan produksi tanaman di Indonesia sudah membudaya dan membuat ketergantungan akan ketersediaan pupuk, khususnya pupuk anorganik. Ketergantungan terhadap pupuk anorganik ini dialami juga oleh petani di Desa Cileles. Harga pupuk anorganik yang tidak stabil dan banyaknya limbah hasil pertanian yang terbuang sia-sia menjadi topik permasalahan bagi petani dan lingkungan sekitarnya. Penggunaan pupuk organik cair yang dibuat dari limbah pertanian dapat menjadi salah satu solusi masalah tersebut. Pelaksanaan Pengabdian Kepada Masyarakat (PKM) melalui kegiatan penyuluhan berupa pemberian pengetahuan kepada petani di Desa Cileles terkait penggunaan pupuk organik cair yang terbuat dari limbah pertanian guna meningkatkan hasil tanaman sayuran dan pemberian kuisioner yang diisi sebelum dan setelah dilakukan penyuluhan untuk mengetahui apakah terdapat peningkatan pengetahuan petani setelah mengikuti penyuluhan. Data dianalisis menggunakan Uji Dua Sampel Berpasangan (Paired Sample T-Test) pada taraf kepercayaan 95%. Hasil kegiatan menunjukkan terdapat peningkatan pengetahuan petani terkait pupuk organik cair dan pupuk hayati cair setelah diberikan penyuluhan.
Pengaruh Motivasi Belajar Terhadap Kemandirian Belajar Siswa SMK Negeri 2 Kendari
Authors: Permata Sari Rezky , Renata Dian , Utami Sri
Published: June 2022

Learning autonomy is the ability of students to direct themselves to learn autonomously without any encouragement from other parties. On the other hand, it is suspected that students will not be able to achieve independent learning without having a strong learning motivation. In some literature it is found that the condition of learning motivation has the potential to have an influence on the birth of learning independence in students. This study aims to determine whether learning motivation affects the learning independence of students at SMK Negeri 2 Kendari. This research is a quantitative research with a survey type. The population in this study were all students of SMK Negeri 2 Kendari in the academic year 2021/2022 with a total of 558 students. The sample was estimated by random sampling technique. To determine the sample size, Slovin's formula is used with a degree of error of 0.05 so that the sample is 233 students. Data were collected through a scale of motivation and learning independence. Data were analyzed both descriptively and through inferential statistics. The results showed that: a) students’ learning motivation was in the medium category, b) students’ learning independence was in the medium category, and c) learning motivation had a significant influence on the learning independence of SMK Negeri 2 Kendari students.
The Effectiveness of Cognitive Behavioral Therapy Techniques on Academic Anxiety in Final Year Students
Authors: Salsabilla Najwa Inaya , Wahyunengsih  , Sari Adelia Puspita
Published: June 2022

This study aimed to determine the effectiveness of Cognitive Behavioral Therapy (CBT) techniques on academic anxiety problems that occur in final year students. The object of this research is final year students who have academic anxiety problems. The method used in this study is a qualitative descriptive method with a case study approach, where the researcher deepens the problem with the subject through various information about the factors that cause academic anxiety and then after therapy how the changes, so that it will be able to describe how the CBT technique can be implemented. Data collection is done by interviewing counselors. The results showed that the Cognitive Behavior Therapy technique could reduce final-year students’ academic anxiety.
The Existence Of The Quarter Life Crisis Phenomenon and Its Effect On Student Self Confidence
Authors: Anggraini Juniar Dwi , Wahyunengsih  , Aqila Syifa Anvitariany
Published: June 2022

Tujuan penelitian ini adalah untuk mengetahui tingkat quarter life crisis, tingkat kepercayaan diri mahasiswa UIN Syarif Hidayatullah Jakarta dan apakah terdapat pengaruh quarter life crisis terhadap kepercayaan diri. Objek dalam penelitian ini adalah mahasiswa UIN Syarif Hidayatullah Jakarta yang berusia 20 sampai 25 tahun. Jumlah responden pada penelitian ini adalah 40 responded. Data dan penelitian ini dikumpulkan dengan teknik metode kuesioner, selanjutnya data dianalisis menggunakan teknik kualitatif dengan menggunakan analisis fenomenologi. Setelah data dianalisis dapat disimpulkan bahwa tingkat quarter life crisis pada mahasiswa UIN Jakarta menunjukkan kategori sedang, sedangkan tingkat kepercayaan diri pada mahasiswa UIN Jakarta menunjukkan kategori sedang. Hasil penelitian menunjukan bahwa quarter life crisis ini merupakan perubahan emosional yang terjadi pada masa perkembangan dari remaja menuju dewasa yang menimbulkan perasaan cemas dan khawatir yang berlebihan terhadap kehidupan yang akan datang.
Rola wczesnej diagnozy i leczenia stwardnienia rozsianego
Authors: Świderek-Matysiak Mariola
Published: June 2022

Stwardnienie rozsiane (SM, sclerosis multiplex) jest uważane za najczęstszą nabytą chorobę demielinizacyjną ośrodkowego układu nerwowego. SM jest chorobą, na którą zapadają ludzie młodzi, najczęściej między 20. r.ż. a 40. r.ż. Diagnostyka SM jest złożona, należy w niej uwzględnić przeszłość chorobową, wywiad rodzinny, obraz kliniczny, obraz radiologiczny oraz wyniki badań laboratoryjnych krwi i płynu mózgowo-rdzeniowego. Obecnie w diagnostyce są stosowane kryteria diagnostyczne McDonalda z 2017 r., które pozwalają wcześnie postawić diagnozę. Wprowadzenie leczenia modyfikującego przebieg SM jak najwcześniej chroni chorych przed kolejnymi rzutami, zmianami radiologicznymi w mózgu i rdzeniu kręgowym, ale również przed zanikami mózgu i niepełnosprawnością.
Komentarz do artykułu Kane’a i wsp. Effect of Long-Acting Injectable Antipsychotics vs Usual Care on Time to First Hospitalization in Early-Phase Schizophrenia: A Randomized Clinical Trial
Authors: Wichniak Adam
Published: June 2022

Kane i wsp. udowodnili, że stosowanie arypiprazolu w postaci iniekcji o długim działaniu zmniejsza ryzyko hospitalizacji o 44%. W grupie pacjentów leczonych iniekcjami o długim działaniu co najmniej jedna hospitalizacja w okresie obserwacji wystąpiła u 22% osób, w grupie otrzymującej leczenie standardowe – u 36% osób. Oznacza to, że w grupie 7 pacjentów ochroniła ona przed hospitalizacją o jedną osobę niż leczenie standardowe.
Liraglutyd – jak osiągnąć cele terapeutyczne – miesiąc, rok czy terapia przewlekła?
Authors: Walczak Marta
Published: June 2022

Podstawową zasadą leczenia choroby otyłościowej jest leczenie kompleksowe. Cele terapii powinny być indywidualnie dobierane do pacjenta i zależeć przede wszystkim od chorób współistniejących oraz ewentualnie występujących powikłań. Analogicznie do innych chorób przewlekłych, m.in.: nadciśnienia tętniczego, cukrzycy typu 2, przewlekłych zespołów wieńcowych, strategia leczenia choroby otyłościowej powinna obejmować metody niefarmakologiczne, farmakoterapię oraz, w razie braku skuteczności, leczenie operacyjne. Rekomendowany czas trwania farmakoterapii wynosi min. 12 miesięcy. Liraglutyd działa centralnie na neurony proopiomelanokortyny (POMC)/CART, zwiększając uczucie sytości oraz zmniejszając głód, z przejściowym efektem zmniejszającym opróżnianie żołądka, dzięki czemu kontroluje łaknienie.

Spośród wielu korzystnych cech liraglutydu do udokumentowanych i szczególnie ważnych z klinicznego punktu widzenia zalicza się: pozytywny wpływ na zaburzenia gospodarki węglowodanowej, działanie kardioprotekcyjne na zmniejszenie ryzyka zgonu z przyczyn sercowo-naczyniowych, zawału lub udaru niezakończonego zgonem oraz zmniejszenie ciśnienia skurczowego u osób z nieprawidłową glikemią bądź bez niej w stosunku do placebo.
Preparat zawierający niezmydlające się frakcje oleju awokado i oleju sojowego w leczeniu choroby zwyrodnieniowej stawów
Authors: Kucharz Eugeniusz Józef
Published: June 2022

Preparat niezmydlających się frakcji oleju awokado i oleju sojowego jest mieszaniną uzyskiwaną według ściśle określonej procedury. Stosuje się go od dawna w leczeniu pacjentów z chorobą zwyrodnieniową stawów; wykazuje on działanie przeciwzapalne, przeciwbólowe i chondroprotekcyjne. Należy do wolno działających objawowych leków stosowanych w chorobie zwyrodnieniowej stawów. Działanie tej mieszaniny udokumentowano w badaniach in vitro, badaniach na modelach zwierzęcych oraz badaniach klinicznych. Wykazano, że zmniejsza ona ból spoczynkowy i występujący podczas ruchu, zmniejsza zapotrzebowanie na niesteroidowe leki przeciwzapalne i inne leki przeciwbólowe, a także poprawia stan czynnościowy narządu ruchu chorych. Preparat ten jest bardzo dobrze tolerowany i nie wykazuje interakcji z innymi lekami.
Przypadki kliniczne pacjentów leczonych tadalafilem oraz solifenacyną
Authors: Sapilak Bartosz J.
Published: June 2022

W artykule przedstawiono zasady terapii dwoma lekami urologicznymi – tadalafilem i solifenacyną. Zaprezentowano również przypadki kliniczne omawiające ich praktyczne zastosowanie. Pierwszy wykorzystywany jest głównie w leczeniu zaburzeń wzwodu i przerostu prostaty, drugi w terapii naglącego nietrzymania moczu, częstomoczu i parcia naglącego. Działanie tadalafilu opiera się na selektywnej i odwracalnej inhibicji specyficznej fosfodiesterazy cGMP typu 5. Zahamowanie aktywności enzymu przez tadalafil prowadzi do hamowania rozpadu i nasilenia działania cGMP w ciałach jamistych prącia, co przedłuża relaksację mięśni gładkich i powoduje napływ krwi do tkanek członka, a tym samym pomaga uzyskać i utrzymać wzwód. W tym wskazaniu lek stosujemy doraźnie, nie częściej niż 1–2 razy w tygodniu. W terapii łagodnego przerostu stercza leczenie opiera się na mniejszych dawkach tadalafilu, ale przyjmowanych codziennie.

Rozpoznanie zespołu pęcherza nadreaktywnego wymaga przede wszystkim zebrania wywiadu lekarskiego, wykonanie badania urodynamicznego nie jest konieczne. W terapii stosujemy leki antycholinergiczne, jednym z nich jest solifenacyna. Lek charakteryzuje wysokie powinowactwo do znajdujących się w pęcherzu i cewce moczowej receptorów muskarynowych M3 i M, cecha ta leży u podłoża dobrej tolerancji solifenacyny przez chorych. Rozpoznanie i leczenie obu omawianych zaburzeń leży w kompetencjach lekarzy rodzinnych, mają oni pełne prawo do diagnozowania problemu, ustalenia rozpoznania i inicjacji adekwatnej terapii.
Ozanimod w terapii rzutowo-remisyjnej postaci stwardnienia rozsianego – opisy przypadków
Authors: Bonek Robert
Published: June 2022

Stwardnienie rozsiane jest przewlekłą, zapalną, autoimmunologiczną i neurozwyrodnieniową chorobą ośrodkowego układu nerwowego charakteryzującą się obecnością zmian demielinizacyjnych rozsianych w przestrzeni i czasie. Jedną z opcji terapeutycznych mających zastosowanie w leczeniu modyfikującym przebieg choroby są modulatory receptora sfingozyno-1-fosforanu. Ozanimod jest nowym selektywnym modulatorem sfingozyno-1-fosforanu o potwierdzonej wysokiej skuteczności i bezpieczeństwie leczenia. Przedstawione przypadki chorych leczonych ozanimodem potwierdzają wcześniejsze wyniki badań w zakresie skuteczności i bezpieczeństwa tego leku w populacji chorych zarówno z wczesnym, jak i zaawansowanym rzutowo-remisyjnym stwardnieniem rozsianym.
Mianseryna i jej wykorzystanie w praktyce lekarskiej
Authors: Patejuk-Mazurek Iwona
Published: June 2022

Mianseryna to lek przeciwdepresyjny z długą historią stosowania, nie tylko na rynku polskim. Jest zarejestrowana do leczenia epizodów depresyjnych, jednakże z powodu wielu działań, jakie wykazuje, może być stosowana (off-label) w różnych innych sytuacjach klinicznych. Niniejszy artykuł wskazuje możliwości wykorzystania potencjału leku w codziennej praktyce lekarskiej.
Kandesartan – od początku i na lata dla ochrony serca i mózgu
Authors: Stolarz-Skrzypek Katarzyna
Published: June 2022

Kandesartan charakteryzuje się najwyższą spośród antagonistów receptora angiotensynowego selektywnością wobec receptorów AT1, wykazuje wysoką biodostępność i całodobowe działanie hipotensyjne. Skuteczność hipotensyjna kandesartanu została udowodniona u pacjentów z nadciśnieniem tętniczym od łagodnego stopnia do ciężkiego nadciśnienia, zarówno dla monoterapii, jak i skojarzeń kandesartanu z antagonistą wapnia lub diuretykiem. Kandesartan zgodnie z aktualnymi wytycznymi może być stosowany do rozpoczynania terapii przeciwnadciśnieniowej, zwłaszcza wobec dostępności jego połączeń z lekami hipotensyjnymi innych klas w postaci leku złożonego. Bezpieczeństwo i bardzo dobra tolerancja kandesartanu czynią go lekiem przydatnym do stosowania przez kolejne lata terapii, a udowodnione właściwości kardio- i neuroprotekcyjne pozwalają korzystnie wpływać na rokowanie sercowo-naczyniowe pacjentów.
Wykorzystanie żelu nimesulidowego w leczeniu bólu z perspektywy fizjoterapeuty
Authors: Chomiuk Tomasz , Brzozowski Arkadiusz
Published: June 2022

W praktyce fizjoterapeuty najczęstsze problemy, z którymi zgłaszają się pacjenci, to ból i ograniczenia z nim związane, wpływające na aktywności codzienne. Zwiększona długość życia, której towarzyszą postępujące procesy inwolucyjne, wraz z trendem do zwiększania aktywności fizycznej – a tej z kolei często towarzyszą urazy – nierzadko prowadzi do konieczności pracy z fizjoterapeutą nad powrotem do pełnej sprawności. W leczeniu pacjentów odczuwających ból często główne narzędzie fizjoterapii, jakim są ruch i ćwiczenia, nie może być w pełni zastosowane ze względu na świeżość urazu lub poziom sensytyzacji tkanek w bólu przewlekłym. W sytuacji, gdy konieczne jest włączenie leczenia przeciwzapalnego i przeciwbólowego równolegle z fizjoterapią, dobre rozwiązanie stanowi wykorzystanie jednego z niesteroidowych leków przeciwzapalnych – nimesulidu w żelu. Jako lek dużo silniej powinowaty do COX-2 ma on mniejszą liczbę działań niepożądanych niż klasyczne niesteroidowe leki przeciwzapalne. Lek w postaci żelu nie tylko trafia w miejsce faktycznie najbardziej bolesne, ale również jest znacznie mniej obciążający w porównaniu ze środkami podawanymi doustnie.
Clinicopathological findings in and prognostic factors for domestic rabbits with liver lobe torsion: 82 cases (2010–2020)
Authors: Ozawa Sarah M. , Graham Jennifer E. , Guzman David Sanchez-Migallon , Tucker Samuel M. , Petritz Olivia A. , Sullivan Patrick , Robertson James B. , Hawkins Michelle G.
Published: June 2022

OBJECTIVE

To document clinicopathologic findings in domestic rabbits with liver lobe torsion and identify prognostic factors.

ANIMALS

82 rabbits.

PROCEDURE

Medical records of 4 institutions were reviewed to identify rabbits with an antemortem diagnosis of liver lobe torsion that were examined between 2010 and 2020.

RESULTS

The prevalence of liver lobe torsion was 0.7% (82/11,402). In all 82 rabbits, the diagnosis was made by means of abdominal ultrasonography. Fifty (60.1%) rabbits underwent liver lobectomy, 23 (28%) received medical treatment alone, and 9 (10.9%) were euthanized or died on presentation. Overall, 32 (39%) rabbits died within 7 days of initial presentation and 50 (61%) survived. Seven-day survival rate did not differ significantly between medical treatment alone and surgical treatment. However, median survival time following medical treatment (530 days) was shorter than that following surgical treatment (1,452 days). Six of 14 rabbits had evidence of systemic inflammatory disease on necropsy. Rabbits with right liver lobe torsion were less likely to survive for 7 days than were those with caudate torsions (P = 0.046; OR, 3.27; 95% CI, 1.04 to 11.3). Rabbits with moderate to severe anemia were less likely to survive for 7 days than were rabbits that were not anemic or had mild anemia (P = 0.006; OR, 4.41; 95% CI, 1.55 to 12.51). Other factors associated with a decreased 7-day survival rate were high heart rate at admission (P = 0.013) and additional days without defecation after admission (P < 0.001). Use of tramadol was associated with an increased survival rate (P = 0.018).

CLINICAL RELEVANCE

The prognosis for rabbits with liver lobe torsions was more guarded than previously described. Rabbits that underwent liver lobectomy had a longer median survival time than did rabbits that only received medical treatment.
Effect of pasteurization on melatonin concentration in human breast milk
Authors: Chrustek Agnieszka , Sinkiewicz-Darol Elena , Lampka Magdalena , Olszewska-Słonina Dorota , Sperkowska Beata , Linowiecka Kinga
Published: June 2022

Introduction

Women who have problems with lactation can use human milk banks. Mainly this human milk is provided to premature babies and sick newborns. Human milk is the most suitable food for newborns and infants, recommended by WHO (World Health Organization). Human milk has anti-inflammatory, anti-infective, and anti-allergic properties, and also works for immunomodulation. Melatonin has a special, underestimated importance in the composition of breast milk. It is a hormone that has many body functions and, for several decades, its antioxidant potential has been increasingly talked about.

The aim of the study was to examine the effect of Holder pasteurization on melatonin concentration in human milk.

Materials and Methods

18 samples of human milk from donors from the human milk bank were used for the analysis. Melatonin concentration before and after pasteurization was determined by ELISA. In addition, the nutritional content composition of milk was analyzed using MIRIS Human Milk Analyzer and correlations examined.

Results

Melatonin concentration in human milk before pasteurization was 0.65–26.24 pg/mL (Me=9.58, IQR=12.72), while after pasteurization 0.80–29.58 pg/mL (Me=9.98, IQR=11.26). There was a positive correlation between melatonin concentration before and after pasteurization (r=0.797, p<0.001).

Conclusions

The Holder pasteurization process does not affect the concentration of melatonin in milk samples, which may be a recommendation for human milk banks.
GRZYBY ENDOFITYCZNE W ROLI POTENCJALNYCH PRODUCENTÓW ZWIĄZKÓW PRZECIWNOWOTWOROWYCH
Authors: Getinger-Panek Agnieszka , Bednarek Ilona
Published: June 2022

Streszczenie

Główną rolę w chemioterapii raka od ponad 50 lat, stanowią leki pochodzące w większości ze źródeł naturalnych. Przeciwko licznym dolegliwościom od stuleci rośliny służyły jako źródło związków bioaktywnych. Jednak to nie same rośliny, a mikroorganizmy z nimi związane oferują materiał i produkty o wysokim potencjale terapeutycznym. Endofity to organizmy, które kolonizują wewnętrzne tkanki roślin bez wywoływania objawów chorobowych. Stanowią endosymbiotyczną grupę drobnoustrojów, będących źródłem nowatorskich produktów naturalnych do wykorzystania we współczesnym przemyśle, rolnictwie oraz medycynie wykazując potencjalne właś ciwości terapeutyczne, w tym przeciwnowotworowe oraz przeciwdrobnoustrojowe, a także przeciwzapalne i antyoksydacyjne. Grzyby endofityczne stanowią bogate źródło bioaktywnych metabolitów, którymi można manipulować w celu uzyskania pożądanych, nowych analogów wykorzystywanych w chemioterapii, w tym: taksol, kamptotecyna, podofilotoksyna, winblastyna, winkrystyna, cytochalazyny i szereg innych. W tym przeglądzie podano przykłady produkcji związków przeciwnowotworowych przez grzyby endofityczne opublikowane od 2015 roku.
Possibilities of geoinformational analysis for assessment of the state and directions of development of geodetic support of the territory of Ukraine
Authors: Bespalko Ruslan , Kazimir Ivan , Hutsul Taras
Published: June 2022

Topographic, geodetic and cartographic activities are one of the main activities for the effective development of the economy, science of strengthening national security and defense. It is a set of management, production, scientific and educational activities for the storage and communication to users of geodetic and cartographic information and data. The article considers one of the segments of this activity – the state of geodetic support of the territory of Ukraine and its assessment according to official data on the possibility of creating topographic maps and plans of scale 1:25 000 – 1:2000 in compliance with applicable regulations. To carry out the assessment, around the points of the State Geodetic Network of Ukraine (DGM) buffer zones of radii of circles of standard sizes were constructed, zoning of the territory with Thissen-Voronoi polygons and covering of the territory in the form of a hexagonal grid were done by means of ArcGIS. The results of the current assessment as of 2022 conducted by three methods are summarized in the table in terms of oblasts of Ukraine. The data obtained are compared to the previous assessment conducted five years ago. Changes in the state of geodetic support have been identified and their objective reasons explained. The advantages and disadvantages of each of the proposed methods of geoinformation analysis of the assessment of the state of geodetic support of the territories are given. It is established that the combination of different methods will allow to use the existing points of DGM with greater efficiency and to substantiate the priority places for further development of the network. The complex of scientific and applied works related to the modernization of the state geodetic network will allow to quickly and locally develop a network based on satellite and computer technologies and create and present digital cartographic information at the modern scientific and technical level in accordance with current needs.
Removal of Cd, Cu, Ni, and Pb from Nanoscale Zero-Valent Iron Amended Soil Using 0.1 M Acetic Acid Solution
Authors: Danila Vaidotas , Januševičius Tomas
Published: June 2022

The purpose of the study was to evaluate the possibility of removing heavy metal cations from single-metal spiked soil samples, which were pretreated with nanoscale zero-valent iron (nZVI) particles. Sandy soil was artificially contaminated with copper (Cu), cadmium (Cd), nickel (Ni), and lead (Pb). Contaminated soil samples were amended with different doses of nZVI (0.35, 0.70 and 1.05 %). A sequential extraction method was used to determine the fractionation of heavy metal cations in the control and nZVI amended soil samples. A solution of 0.1 M acetic acid (pH 3.0) was used to investigate the removal of heavy metals from control and nZVI-amended soil samples. The results showed that nZVI reduced the amount of metals in the exchangeable form and increased the proportion of these metals associated with amorphous iron (Fe) oxides. The results also showed that the removal efficiencies of heavy metals increased with increasing nZVI dose, that is, from 46.9 %, 5.77 %, 33.5 %, and 2.70 % to 55.9 %, 12.3 %, 46.2 %, and 3.79 % for Cd, Cu, Ni, and Pb, respectively. The study indicated that the application of nZVI in soil could be beneficial for subsequent removal of heavy metals from soil using 0.1 M acetic acid solution.
Ação de impugnação pauliana contra devedor insolvente – efeitos insolvenciais da procedência da ação
Authors: Silva Pereira Fernando
Published: June 2022

This article discusses the problem of knowing whether, if an actio pauliana is filed to contest an act performed by an insolvent debtor (or one that has been declared insolvent in the meantime), the effects of the granting of this action will benefit only the claimant creditor (who has the right to the execution of the asset directly in the third party acquirer's legal sphere - Article 616(1) CC - competing with the other creditors of the third party acquirer) or whether, on the contrary, should the object of the contested transaction return to the debtor's legal sphere, entering the insolvent estate and thus benefiting all of the insolvent debtor's creditors (principle of par conditio creditorum). In the previous legal regime, the CPEREF, there was a figure, the collective actio pauliana, which disappeared in the current CIRE, being absorbed by the regime of "unconditional resolution". In addition to a problem of articulation of the action of actio pauliana (singular) with the regime of resolution for the benefit of the insolvent mass (see Article 127 CIRE), there is the problem of the insolvency effects of the granting of such action. Article 127 CIRE, in particular paragraph 3 of this article, leaves doubts on this matter, and there is no total uniformity in doctrine and jurisprudence.
Recensión a Giménez Zuriaga, Isabel (Dir.): Retos de la sociedad digital y medios de pago, Thomson Reuters, Navarra, 2019, 341 pp. (ISBN 9788413095127)
Authors: López Jiménez David
Published: June 2022

Book review of Giménez Zuriaga, Isabel (Dir.): Retos de la sociedad digital y medios de pago, Thomson Reuters, Navarra, 2019, 341 pp. (ISBN 9788413095127)
Testing The Determinants Of Corporate Reputation And Their Impact On Market Valuation
Authors: Tamara Limbunan  , Fransiskus Eduardus Daromes
Published: June 2022

This study examines model of the determinants of corporate reputation, namely managerial ability and corporate social performance and their impact on market valuation. Theoretical model is built based on Resource-based theory and signaling theory. Population of this study are all companies listed on the Indonesia Stock Exchange in 2017 – 2020. The results of this study indicate that there is an influence between managerial ability and corporate social performance on corporate reputation. This study also finds that corporate reputation has an effect on market valuation, however, both managerial ability and corporate social performance have no effect on market valuation. Subsequent testing shows that corporate reputation mediates the relationship between managerial ability and corporate social performance on market valuation.
The Politicization of an Ethnic Minority: The Case of the Polish Minority in Lithuania
Authors: Onishchenko Anton , Busygina Irina
Published: June 2022

The politicization of ethnic minority is a common phenomenon despite the fact that its manifestation may differ in different contexts. The configuration of the factors that have an impact on the politicization of ethnic minorities varies in different countries as well. For the case of the Poles in Lithuania the main factors are the following: the policy of the Lithuanian state restricting the use of the Polish language in schools, the EU membership of the Lithuanian Republic and the policy of Warsaw in terms of protecting the Polish minority in the neighbour state, as well as the existence of the similarly large minority group in Lithuania - the Russians.
Contemporary Refugee Policy in Russia in 2012–2021: Contradiction between Refuge Legislation and its Implementation in Practice
Authors: Lyapina Alfiya
Published: June 2022

This paper provides an overview of the contemporary legal framework of the refugee policy in Russia and illustrates its practical implementation based on the most recent cases of Ukrainian and Syrian forced migration flows. The analysis is based on the results of the participant observation, in-depth interviews with experts and refugees, as well as descriptive statistics and document analyses. Also, it is explaining the stages of the path that refugees travel through within Russia in their attempts to obtain asylum or other legal statuses. We show how they are acting within the framework of the law, even if they are likely not to succeed in this.
National Minorities and Ethnic Relations in the Baltic States
Authors: Pettai Vello
Published: June 2022

During the 1990s, the Baltic states were considered a potential hotspot of ethnic tension and possible conflict, primarily because of sizeable Russian-speaking populations that had become minorities after the collapse of the Soviet Union. By the 2000s, some of this friction began to subside, as more integrative policies were adopted and accommodative attitudes developed. Today, the three countries still face some of these core minority challenges, including Lithuania’s notable Polish minority. However, new minority groups have also emerged as a result of European integration and globalization, thus continually changing the majority-minority configuration in these countries.