bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of events from sudden isolated dysarthria to diagnosis of myasthenic crisis: myasthenia gravis mimicking acute lacunar stroke—a case report
Authors: Miletic Simona Petkovic , Ahmed Sheikh Ruksana Binte
Published: July 2024

Background

Myasthenic crisis (MC) is a life-threatening complication of myasthenia gravis (MG), necessitating ventilation. Achieving a safe and timely diagnosis of myasthenic crisis with atypical, isolated presentation is a considerable challenge particularly in elderly patients, where myasthenia gravis can present with isolated dysarthria in rare instances, giving a clinical impression of lacunar stroke.

Case presentation

We present a compelling case of a 73-year-old Caucasian female presenting with abrupt onset of isolated dysarthria. Despite initial treatment for a presumed lacunar stroke, subsequent evaluations led to her diagnosis of a myasthenic crisis. Within 72 h of admission, the patient developed dysphagia and shortness of breath, requiring supplemental oxygen. The case highlights the sequential progression of events from the atypical presentation of isolated dysarthria and its course to the management of a myasthenic crisis.

Conclusion

Our reported case focuses on the discussion of myasthenia that mimicked a lacunar stroke and was finally diagnosed at a critical time of medical crisis. This case highlights the imperative notion that isolated dysarthria in elderly individuals warrants vigilant monitoring for possible myasthenia gravis, given the low incidence of lacunar stroke presenting with only dysarthria.
Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy
Authors: Han Ruiming , Zhu Dongdong , Sha Jichao , Zhao Boning , Jin Peng , Meng Cuida
Published: July 2024

Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass a significant category of IgE-mediated atopic disorders, including asthma, allergic rhinitis, atopic dermatitis, and food allergies. These complex conditions arise from the intricate interplay between genetic and environmental factors and are known to contribute to socioeconomic burdens globally. Recent advancements in the study of allergic diseases have illuminated the crucial role of DNA methylation (DNAm) in their pathogenesis. This review explores the factors influencing DNAm in allergic diseases and delves into their mechanisms, offering valuable perspectives for clinicians. Understanding these epigenetic modifications aims to lay the groundwork for improved early prevention strategies. Moreover, our analysis of DNAm mechanisms in these conditions seeks to enhance diagnostic and therapeutic approaches, paving the way for more effective management of allergic diseases in the future.
Anti-thrombotic effects of arteanoflavone by regulating cyclic nucleotides and aggregation on human platelets
Authors: Choi Ho Keun , Kim Ga Yeon , Lee Ga Hee , su Jang Hee , Kang Da Hyeon , Lee Jin Pyo , Lee Dong-Ha
Published: July 2024

Excessive clotting or abnormal platelet accumulation can lead to serious cardiovascular disorders such as atherosclerosis, stroke, and thrombosis. Therefore, it is imperative to identify compounds capable of controlling or impeding platelet aggregation to prevent the onset of cardiovascular diseases. Arteanoflavone, a compound extracted from Artemisia iwayomogi, has not garnered scientific recognition for its potential health benefits, recent studies have substantiated its anti-inflammatory, antioxidant, and anti-allergic properties. However, the precise mechanisms by which arteanoflavone influences platelet aggregation and blood clot formation have not been conclusively established. This research investigates arteanoflavone’s role in these processes, particularly in platelets induced by collagen. The study reveals a significant increase in the production of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) correlating with the administered dosage of arteanoflavone. Concurrently, a noticeable escalation is observed in substrates of cAMP-dependent kinase and cGMP-dependent kinase, specifically VASP and inositol 1,4,5-trisphosphate receptor (IP3R).

Arteanoflavone demonstrates its ability to limit Ca2+ movement in the dense tubular system through IP3R phosphorylation. Moreover, phosphorylated VASP inhibits the binding of fibrinogen to αIIb/β3, thus suppressing platelet activity. Arteanoflavone also stimulates the phosphorylation of PI3K/Akt, a protein linked to platelet granule release, and MAPK (ERK, JNK, and p38) protein, associated with both platelet granule release and TXA2 production.

Lastly, arteanoflavone impedes collagen-induced platelet aggregation and blood clot formation by inhibiting fibrin production in thrombin-induced platelets. Hence, it is suggested that arteanoflavone could be valuable as an agent that effectively deters platelet inhibition and blood clot formation through antiplatelet mechanisms.
Are university students really hungry for sustainability? A choice experiment on new food products from circular economy
Authors: di Santo Naomi , Califano Giovanbattista , Sisto Roberta , Caracciolo Francesco , Pilone Vittoria
Published: July 2024

Consumers are demonstrating increasing awareness towards initiatives promoting sustainable practices in the food sector. This is particularly pronounced among university students, a segment known for its receptivity to sustainability initiatives. Utilizing a choice experiment, this study examines the Italian students’ preferences for fruit juice produced by a hypothetical company. Specifically, the research explicitly assesses the premium price attributable to a circular economy certification—a relatively new standard—in comparison with the widely recognized and appreciated organic certification. Furthermore, the study evaluates the potential additive value of possessing both certifications jointly. Results indicate that consumers are willing to pay a premium for products labelled with circular economy attributes. However, in the presence of an organic certification, the additive value of the circular economy certification is diminished by more than half. Finally, consumers who have received environmental training demonstrate a higher premium for such products, highlighting the role of education in promoting sustainable choices. These findings suggest that a potential market exists for circular economy-certified products, providing an incentive for businesses to adopt circular economy practices. Environmental training plays a relevant role in fostering sustainable transitions, thereby underscoring the significance of education in shaping conscious consumer behaviour.
Water-holding properties and electrochemical characterization of the soil under the Grand Deliverance Hall of the Chongshan Temple, Taiyuan City, China: providing the basis for preventing groundwater erosion in historic buildings
Authors: Lu Yi , Bai Xiangling , Wang Xiaolong , Han Lin , Bai Xiaojian , Han Pengju , An Yijing
Published: July 2024

Many historic buildings are at serious risk of deterioration due to changes in the moisture content of the soil under the buildings. Based on the typical deterioration problems of the Grand Deliverance Hall and the cultural relics in the hall, this study analyzes and concludes that the main factor affecting the generation and development of deterioration is groundwater erosion through environmental monitoring and geotechnical engineering investigation. The impact of changes in moisture content on the water-holding properties and pore distribution of the soil under the cultural-relics buildings was further assessed. Then, combined with the soil property, our study provides a novel and effective way to monitor and reflect the water-holding properties of the soil using electrochemical detection. The connected pore resistance and matrix suction decrease with the increase in the moisture content, both showing a power function law. Changes in moisture content cause changes in the thickness of the double electric layer, which in turn affects the connected pore resistance and matrix suction of soil. The greater the connected pore resistance, the greater the matrix suction and the water holding capacity. Finally, based on the research of this study and the conservation ideology of cultural relics that respects the original and minimizes intervention, protection recommendations to prevent groundwater erosion are proposed in order to provide guidance for future research.

Graphical Abstract
‘The Listening Series’: increasing equity, diversity and inclusion in patient and public involvement and engagement for policy research by listening to and learning from under-represented groups
Authors: Bevan Charlotte , Alderdice Fiona , Darby Sally , Gilzean-Hughes Serena , McLeish Jenny , Mulla Sumayya , Plachcinski Rachel , Wilkinson Sophia , Williams Harriet , Rowe Rachel
Published: July 2024

Background

Policy research aims to provide evidence to inform government policy decisions about health and social care. Engaging and involving the public and patients in this work is widely recognised as essential. Research funders prioritise equality, diversity and inclusion (EDI) in patient and public involvement and engagement (PPIE), but people who are most likely to experience poor outcomes are also those least likely to be involved in research. This paper describes our experience of setting out to understand how to overcome barriers to EDI in PPIE in the research carried out by the National Institute for Health and Care Research (NIHR) Policy Research Unit in Maternal and Neonatal Health and Care (PRU-MNHC), in a PPIE consultation project we called The Listening Series.

Methods

We convened five video-recorded online discussion groups involving 20 individuals advocating for groups who are under-represented in our research. Those taking part included people working with Black and Asian women and families, young parents, those from socially deprived backgrounds, and women and families with physical and learning disabilities. Discussions focussed on practical solutions to addressing challenges to people being excluded, and how to improve EDI in our research.

Learning and reflection

Five key themes were identified: ‘build trust’; ‘involve us from the beginning’; ‘show us impact’; ‘use clear, appropriate and inclusive communication’; and ‘imagine life in our shoes’. We used the learning to create a guidance document for researchers and an accompanying 15-minute film. We also took practical steps to embed the learning strategically by expanding our Task Group for PPIE in the PRU-MNHC to include four Listening Series invitees with a remit to champion EDI in our research and ensure that it is embedded in our PPIE activities. We continue to reflect on and work to address the associated challenges.

Conclusions

The Listening Series helped us rethink our processes for inclusion to go beyond traditional methods of involvement and engagement. The themes identified pose challenges that require time, resource and empathic engagement from researchers to be meaningfully resolved. This has implications for policy makers and research funders who need to consider this in their processes.
Uncovering a hidden danger: a case report of diffuse coronary spasm concealing spontaneous coronary artery dissection
Authors: Desario Paolo , Rutigliano David , Palumbo Vincenzo , Caldarola Pasquale
Published: July 2024

Background

Over recent years, spontaneous coronary artery dissection (SCAD) has emerged as a no longer rare cause of acute coronary syndrome (ACS). On the other hand, coronary artery spasm (CAS) is the main cause of ischemic heart disease with non-obstructive coronary lesions. Clinical manifestations of both vary from stable angina to ACS or, rarely, sudden cardiac death. These entities may be underdiagnosed on a coronary angiography.

Case presentation

We report the case of a young woman presenting with acute chest pain and no coronary risk factors. Angiography revealed a focal subcritical stenosis of the right coronary artery. Coronary wiring resulted in diffuse and critical spasm. However, optical coherence tomography (OCT) and intravascular ultrasound (IVUS) showed extensive SCAD. She was therefore treated conservatively. On the fourth day, cardiac computed tomography angiography (CCTA) excluded disease progression, and then she was discharged on medical therapy.

Conclusions

Combined IVI plays a vital role in providing accurate and detailed visualization of the coronary anatomy and thus allowing for more precise diagnosis, risk stratification, and treatment planning. CCTA can be considered a valuable tool in the noninvasive follow-up of SCAD.
From theory to practice in implementation science: qualitative insights from the implementation model developed by a commercial eMental Health provider
Authors: Bastoni Sofia , van Lotringen Charlotte Marijne , Kip Hanneke , Sanderman Robbert , van Gemert-Pijnen Lisette J. E. W. C. , van Dongen Anne
Published: July 2024

Background

Although eMental health interventions are a viable solution to address disparities in access to mental healthcare and increase its efficiency, they still face challenges of implementation. Literature highlights numerous barriers such as diffusion of responsibility and unclear expectations of what implementation entails might hinder this process. While research mostly focuses on analyzing these barriers, there is an urgent need to increase uptake in practice. In turn, commercial companies focus mostly on increasing uptake, while overlooking research outputs. To bridge the gap between research and practice, attention to how implementation occurs in practice is required. This study investigates “Make it Happen” (MiH), the implementation model developed by the eMental Health company Minddistrict, aiming to gain more insight into operationalizing implementation frameworks by 1) describing MiH and its conceptual underpinnings, and 2) gaining lessons learned from the development of MiH. Ultimately, this work aims at improving existing scientific frameworks by extending them with knowledge from practice.

Methods

First, individual interviews and focus groups with Minddistrict implementation managers were performed. Second, individual interviews with project leads in mental healthcare organizations that were involved in the implementation of Minddistrict were conducted. Within Minddistrict, 7 implementation managers and account managers were involved, in addition to 11 project leads from mental healthcare organizations. Data were elaborated with thematic analysis.

Results

A comprehensive description of MiH and its 5 main phases was achieved. During the 1) Onboarding phase, implementing organizations are guided by Minddistrict to build a team responsible for implementation, which then 2) designs patient and client journeys, 3) builds, tailors and configures their offer, 4) trains key-users and, 5) evaluates the success of implementation. All participants had extensive and aligned definitions and articulated expectations on implementation. Points of improvement for the model such as role ambiguity and excessive workload were identified. As strengths, internal motivation and good relationships with the provider were valued.

Conclusion

The present study highlights the importance of clear role division and stakeholder engagement in implementation processes, and suggest that a strong collaboration between companies and academia could optimize implementation efforts and ensure a better fit between humans, context, and technologies.
Kształtowanie jakości wody w Junikowskim Strumieniu na obszarze aglomeracji poznańskiej
Authors: Mazurek Małgorzata
Published: July 2024

Jakość wody w małych ciekach ma istotny wpływ na stan całego systemu rzecznego. Jedną z małych zlewni w aglomeracji poznańskiej, podlegającą różnokierunkowym przekształceniom antropogenicznym, jest zlewnia Junikowskiego Strumienia o powierzchni 48,9 km2, którą odwadnia ciek o długości 12,1 km. Celem pracy było rozpoznanie zróżnicowania właściwości fizykochemicznych wody w profilu podłużnym cieku oraz wskazanie źródeł dostawy substancji rozpuszczonych i ognisk zanieczyszczeń w zlewni. Charakterystykę właściwości fizykochemicznych wód Junikowskiego Strumienia przeprowadzono w oparciu o wyniki analiz hydrochemicznych z profilowań hydrochemicznych przeprowadzonych wiosną 2021 r. i latem 2023 r. Na podstawie badań wód Junikowskiego Strumienia wskazano strefy najbardziej narażone na zanieczyszczenia w zlewni, są to: początek cieku w okolicach lotniska Poznań-Ławica, środkowa część zlewni (od ul. Grunwaldzkiej do linii kolejowej Poznań–Berlin) oraz dolny bieg cieku na terenie Lubonia (od autostrady A2 do ujścia cieku do Warty). Wśród ognisk zanieczyszczeń wyróżniają się wody spływu powierzchniowego z zanieczyszczonych powierzchni uszczelnionych, oddziaływanie infrastruktury komunikacyjnej oraz punktowa dostawa ścieków bytowych. Ograniczaniu rozprzestrzenienia zanieczyszczeń i samooczyszczaniu wody sprzyja litologia osadów oraz zbiorowiska roślinne w dwóch seminaturalnych odcinkach doliny rzecznej, tj. w Lasku Marcelińskim i na Szachtach. Skład chemiczny wód Junikowskiego Strumienia pozwala na ocenę obecnego stopnia antropopresji, co można wykorzystać w zintegrowanym zarządzaniu zasobami wodnymi oraz w zagospodarowaniu zlewni w celu poprawy stanu wody w ciekach w zmieniających się warunkach klimatycznych i urbanistycznych.
Δίκαιο και θάλασσα στο Βυζάντιο
Authors: Ποντικού Μαρία
Published: July 2024

Στην παρούσα διδακτορική διατριβή εξετάζονται το θαλάσσιο περιβάλλον και η εκμετάλλευσή του με βάση τις νομοθετικές διατάξεις σε συνδυασμό με τις μαρτυρίες των σύγχρονων ιστορικών και χρονογράφων από τον 8ο έως και τον 12ο αιώνα. Το πρώτο μέρος πραγματεύεται το θαλάσσιο περιβάλλον. Αρχικά παρουσιάζεται το υφιστάμενο νομικό πλαίσιο για τον αιγιαλό, τις αναδυόμενες νησίδες και τα κτίσματα επ’ αυτών. Στη συνέχεια εξετάζονται οι νόμοι με τους οποίους ο νομοθέτης, ανταποκρινόμενος στην επιθυμία των Βυζαντινών να απολαμβάνουν το φυσικό περιβάλλον και μάλιστα το θαλάσσιο, εξασφάλιζε σε όσους γειτόνευαν με τη θάλασσα την απρόσκοπτη θέα της. Ένα ζήτημα που τίθεται προς διερεύνηση είναι η ισχύς των διατάξεων για τη θέα της θάλασσας και η εμβέλεια της εφαρμογής τους, εάν και κατά πόσον δηλαδή τα μέτρα ίσχυσαν μόνο στην Κωνσταντινούπολη ή επεκτάθηκαν και σε άλλες παραθαλάσσιες πόλεις και περιοχές της βυζαντινής επικράτειας. Οι λιμένες και οι λιμενικές εγκαταστάσεις επίσης απασχολούν την έρευνά μας. Διερευνώνται η ορολογία και η λειτουργία των λιμενικών εγκαταστάσεων με βάση τη νομοθεσία. Σημαντική ήταν και η υπηρεσία των οργάνων διοικήσεως των λιμένων. Φαίνεται ότι οι άρχοντες των κατά τόπους παραθαλασσίων περιοχών της βυζαντινής εποχής είχαν παρόμοια καθήκοντα με τους λιμενάρχες της ρωμαϊκής· ήταν υπεύθυνοι για τον έλεγχο των επιβατών και τη διαφύλαξη της τάξεως. Άλλα θέματα που αναλύονται είναι τα ναυάγια, τα ναυτικά δάνεια και οι τόκοι με εστίαση του ενδιαφέροντος στις διατάξεις που επιβίωσαν από τη ναυτική παράδοση του Νόμου Ροδίων Ναυτικού στον Πανδέκτη και μέσω αυτού στα Βασιλικά. Με τα ναυάγια συνδέονται και τα αδέσποτα πράγματα που καταλήγουν στις ακτές ή τον βυθό της θάλασσας. Το δεύτερο μέρος της διατριβής αναφέρεται στην εκμετάλλευση του θαλασσίου περιβάλλοντος. Ερευνώνται οι μέθοδοι αλιείας, η αξιοποίηση των θαλασσίων πόρων, το εμπόριο των προϊόντων και υποπροϊόντων της θάλασσας και η νομοθεσία περί αυτών. Εξετάζονται οι οικονομικές συναλλαγές των Βυζαντινών, οι αγοραπωλησίες προϊόντων, οι μισθοί, το κέρδος και οι φόροι που εισπράττονταν από τους δημοσίους υπαλλήλους. Εντοπίζονται και συγκρίνονται οι νόμοι για τα ανακυπτόμενα προβλήματα από την εκμετάλλευση της θάλασσας σε σχέση με τις αντίστοιχες μαρτυρίες στις αφηγηματικές πηγές. Για ορισμένα προϊόντα, όπως τα κοράλλια, τα μαργαριτάρια, τα όστρακα, το φύκος, αλλά και μεθόδους αλιείας, όπως η σαγήνη (δίχτυα αλιείας), γίνεται για πρώτη φορά προσπάθεια συστηματικής έρευνας στην παρούσα διατριβή.
Η σπατάλη τροφίμων (food waste) και ο Έλληνας καταναλωτής
Authors: Ζαχαράτος Θεοφάνης
Published: July 2024

Η παρούσα διδακτορική διατριβή εξετάζει τη συμπεριφορά του Έλληνα καταναλωτή σχετικά με το πρόβλημα της σπατάλης τροφίμων. Η έρευνα σε θεωρητικό και εμπειρικό επίπεδο στόχευε στο α) να αναδείξει μέσα από τη βιβλιογραφική ανασκόπηση τις αιτίες που προκαλούν το πρόβλημα της σπατάλης τροφίμων καθώς και επιμέρους στοιχεία και τάσεις του προβλήματος, β) να εξετάσει με την υιοθέτηση ενός ερευνητικού μοντέλου το ρόλο που διαδραματίζει η γενική γνώση που έχει ο καταναλωτής για τα περιβαλλοντικά προβλήματα της σύγχρονης εποχής (κλιματική αλλαγή, υπερθέρμανση του πλανήτη, ατμοσφαιρική ρύπανση, ερημοποίηση και διάβρωση των ακτών) σε συνδυασμό με την εξιδεικευμένη γνώση του καταναλωτή για το πρόβλημα της σπατάλης τροφίμων, τόσο στη διαμόρφωση-επίδραση των καταναλωτικών στάσεων όσο και της καταναλωτικής συμπεριφοράς, δηλαδή τόσο στη διαμόρφωση καταναλωτικών στάσεων σχετικά με τη σπατάλη τροφίμων όσο και της οικολογικά ευσυνείδητης συμπεριφοράς, γ) να διερευνήσει την ύπαρξη διακριτών προφίλ καταναλωτών σχετικά με τη σπατάλη τροφίμων και δ) να διερευνήσει το ρόλο που διαδραματίζουν τα διακριτά προφίλ καταναλωτών καθώς και τα δημογραφικά χαρακτηριστικά των καταναλωτών (φύλο, ηλικία, εισόδημα, μέγεθος νοικοκυριού, επίπεδο εκπαίδευσης και περιβάλλον μόνιμης κατοικίας) στη συμπεριφορά που αναπτύσσουν οι καταναλωτές απέναντι στο πρόβλημα της σπατάλης τροφίμων. Από τα αποτελέσματα της διατριβής προκύπτουν χρήσιμα συμπεράσματα τα οποία μπορούν να αξιοποιηθούν από τους ενδιαφερόμενους φορείς όπως είναι ο δημόσιος τομέας, οι επιχειρήσεις και ο ιδιωτικός τομέας καθώς και οι διάφορες κοινωνικές οργανώσεις και φορείς για τη δημιουργία στοχευμένων παρεμβάσεων με σκοπό τη μείωση της σπατάλης τροφίμων και την υποβοήθηση της ανάπτυξης οικολογικά ευσυνείδητων καταναλωτικών συμπεριφορών.
The Fraudulent Discourse: Strategy of Appeal to Luck
Authors: Smirnova Irina
Published: July 2024

The article examines one of the most frequent and effective strategies in the structure of fraudulent discourse, namely the Strategy of appeal to luck. Speech tactics of manipulative influence within the framework of this strategy, types of messages and communication means used by the fraudster to influence the victim in order to create a certain psychological state are differentiated. The various roles in which con artists can appear, the characteristics of behavior in each of the role models, depending on the scenario and the result of the con planned by the criminal, are described. It is shown how the victim develops a psychological state of anticipation of sudden success in each type of communicative scenario. The main tactics of influence are identified: Tactics of creating a feeling of success in life, Tactics of providing means to achieve well-being, Tactics of instilling a sense of exclusivity. The content, methods of communication influence, the technical and communication means used, the behavioral characteristics of communication participants are revealed for each tactic based on reports of completed or failed acts of fraud posted by users on the pages of entertainment portals, thematic forums, online electronic publications, surveys of victims and interviews with victims.
Factors of Successful Communication in Interprofessional Discourse (Based on Job Interviews)
Authors: Ageeva Yu.
Published: July 2024

The need to identify verbal and non-verbal specifics of the Russian-language employment discourse, and the timeliness of analyzing the communicative behavior of job interviews’ participants (professionals from various areas) have determined the relevance of the present study. In terms of its discourse-forming properties, the professional discourse belongs to the institutional type of discourse. However, unlike other discourse types, the communicative environment in this case is considered interprofessional, since the agent (HR specialist), on one hand, and the client (a specialist from other area), on the other hand, represent different corporate cultures. The author of the article concludes that the effectiveness of the job applicant’s strategic program (a self-presentation strategy) depends on his/her ability to balance between authentic modesty and positive self-presentation. The article presents a newly formulated communicative code based on the analysis of the communicative successes and failures of job applicants. It includes a system of guiding principles, thus allowing job applicants to achieve communicative success during a job interview.

The findings of the study have application in the training of HR experts, as well as in other areas related to the effectiveness of business communication. The study’s outcomes are significant for all potential employees with regard to the efficiency of the communicative behavior of interview participants.
Towards the Communicative Specifics and Rhetoric Features of the Media Model of Political Discourse of the Acting Leader of the French Right — Wing Political Party «Rassemblement National» Jordan Bardella
Authors: Loginova Polina , Ebzeeva Yu.
Published: July 2024

The paper considers the communicative specifics and rhetoric peculiarities of verbal media communicative behavior of one of the major actors on the contemporary French political stage, leader of the French far-right wing Jordan Bardella, Marine Le Pen’s successor, so- called representative of the young generation of contemporary French politicians (as well as Gabriel Attal, acting French prime-minister). It should be emphasized that the rhetoric specifics of Jordan Bardella political communication have not been previously explored within the constraints of the Russian humanities that determine the originality and newness of the paper. The scope of research represents the French political discourse that determines the object of the article consisting of word usages extracted from contemporary French media landscape that embodies diverse types of political speeches pronounced by Jordan Bardella and pervaded online. While studying language units under consideration such methods as method of contextual analysis, component analysis and the descriptive method are being used. It is attempted to illustrate that specifics of J. Bardella’s verbal political behaviour characterizes and exemplifies his political image and perception in the French society. Among the linguistic peculiarities that represent J. Bardella’s verbal behavior the special attention is drawn to metaphorical meanings of the lexical units that reflect the appropriate negative attitude to illegal migrants that currently leave in France. It is also mentioned that by means of metaphors, anaphors, citations used in the speeches of J. Bardella as well as within video public interventions the ideology and ideas of far-right wing are being transmitted that permits to manipulate and influence public consciousness. The practical significance of the paper is considered in implementing the exemple of conducted analysis when teaching the language of French political discourse at Universities.
Botulinum toxin in management of back pain
Authors: Łuczak Blanka , Nowińska Bianka , Słychan Katarzyna , Hądzlik Izabela , Piotrowski Jan , Biały-Karbowniczek Julia , Bulska Klaudia , Brzozowska Patrycja , Piela Andrzej , Sławek Konrad
Published: July 2024

Introduction
The botulinum toxin is a widely used therapeutic agent.  It is used for aesthetic reasons in treatment of glabellar wrinkles. Therapeutic indications include cervical dystonia, hyperhidrosis or migrenes. Also, it can be used in pain management, especially back pain. Back pain is one of the most common pain syndromes decreasing quality of life. Treatment involves  various methods such as conservative and surgical approach. One of the methods is botulinum toxin.
Objectives
This article aims to evaluate usage, mechanism and treatment effects of back pain using botulinum toxin.
Methods
A Literature review of articles published in Pubmed between 2000 and 2024 using following words “botulinum toxin”, “botulinum”, “back pain” and “treatment”.
Results
Botulinum toxin injections are one of the pain management methods used especially in low back pain and myofascial pain syndrome. Treatment relies on its myorelaxant properties and inhibition of neuromodulator secretion such as substance P or acetylocholine. Pain relief effects are noted after three weeks and can last up to six months. In the initial stages a significant amount of patients report relief of pain. 
Conclusion
Botulinum toxin is one of the treatment methods for lower back pain. It is a safe, minimally invasive and effective treatment. Patients can feel the relief even in three weeks and the effects might persist even up to six months.
Assessment of mercury exposure and its impacts on human health
Authors: Kuśmierski Jakub , Kuśmierska Martyna
Published: July 2024

Introduction: Mercury, found both naturally and as a man-made contaminant, affects diverse populations globally, mainly through dietary consumption of seafood and occupational exposure. Mercury poses a significant threat to human, with well-documented adverse effects observed globally, especially among vulnerable communities. The aim of this study was to review the literature on mercury exposure and its effects on human health.
Material and methods of research: A literature review was performed using databases like PubMed and Google Scholar focused on keywords related to the topic.
Brief description of the state of knowledge: Dietary intake, notably from seafood containing methylmercury, constitutes a significant pathway for human mercury exposure. Additionally, occupational exposure, such as in artisanal and small-scale gold mining operations, poses significant risks, particularly in communities residing near these operations. Mercury exposure poses significant health risks across multiple bodily systems, including the nervous, cardiovascular, endocrine, reproductive, gastrointestinal, pulmonary, urinary, and immune system, potentially leading to a wide range of adverse effects. The intricacies of mercury's impact have been extensively discussed in research, delving into its specific mechanisms of harm within each bodily system.
Summary: Although a plethora of studies demonstrate the toxicity of mercury and its detrimental effects on human health, further research exploring this topic is essential, particularly on a pathophysiological level, to comprehensively understand the complex interactions between mercury exposure and its diverse effects on human health across various populations and exposure scenarios.
Is air pollution one of the risk factors for sudden deafness? Review of the literature
Authors: Miłek Magdalena , Banach Mariola , Foryś Angelika , Kmiotek Weronika , Kotowicz Zuzanna , Kwaśniak Ksenia , Magierska Agata , Niemczyk Anna , Stawska Weronika , Ślusarczyk Monika
Published: July 2024

Introduction and objective: Sudden deafness is a serious clinical manifestation characterised by rapidly progressive hearing loss. As the duration of the disease process increases, hearing loss increases, so it is important to diagnose and begin treatment as early as possible. This paper aims to summarise the current state of knowledge on the main risk factors for sudden hearing loss and treatment methods, and the impact of environmental pollution on sudden hearing loss.
Brief description of the state of knowledge: Sudden hearing loss, also known as sudden sensorineural hearing loss, refers to a sudden and significant deterioration of hearing. According to current medical knowledge, risk factors for sudden deafness mainly include microvascular disorders, autoimmune diseases, damage to the cochlear membrane and viral infections. According to some researchers, air pollution may contribute to sudden hearing loss; however, data are still lacking and there is a need for further research. Treatment of hearing loss can include medication, hyperbaric therapy, hearing aids and, in the most difficult cases, cochlear implants. Sudden deafness is a health problem with a significant impact on patients' quality of life. Understanding the causes, diagnosis and effective treatment are key to improving quality oflife and social and occupational functioning.Methods and results: Literature review was performed using the PUBMED online database and Google Scholar.Summary: Hearing loss is a common condition that can have a variety of causes and dangerous consequences. This article discusses the causes of sudden hearing loss and available treatments. The need for further research into the treatment and rehabilitation of people with hearing loss to ensure the best possible quality of life and to improve social and occupational functioning is highlighted.
A case of Legionella pneumonia with rhabdomyolysis, with extremely high creatinine kinase without acute kidney injury in an adult
Authors: Sangam Sangam , Malik Sehrish , Hodo Franc , Patel Bhawesh , Bengualid Victoria , Sharma Shorabh
Published: July 2024

Legionella pneumophila is a bacterium that usually causes pulmonary disease but can rarely present with extrapulmonary manifestations, such as rhabdomyolysis. This is a case of Legionella infection with significant rhabdomyolysis but a lack of acute kidney injury. A 38-year-old male with a history of epilepsy presented to the emergency department after a seizure episode with confusion, fever, emesis and bruises. He also complained of a productive cough and scant haemoptysis for the past two months. Chest X-ray showed retrocardiac and left upper lobe opacities; urine was positive for Legionella antigen and myoglobinuria. Creatinine phosphokinase was 242,488 U/l and creatinine was 0.5 mg/dl. The patient was managed with oxygen therapy, aggressive IV hydration and IV azithromycin, and later IV levofloxacin until his symptoms resolved. Rhabdomyolysis may be a sign of Legionella infection. Rapid testing of Legionella antigen, especially in populations at risk, may be crucial for timely diagnosis and treatment. Kidney function may be preserved in the early stages of disease, but early treatment with antibiotics and aggressive hydration are an effective way to prevent deterioration in kidney function.
The great mimicker: a unique case of diffuse subarachnoid haemorrhage simulating acute myocardial infarction
Authors: Gerges Mina , Bathobakae Lefika , Mahmoud Anas , Saad Remon , Elkattawy Sherif , Shamoon Fayez , Ismail Mourad
Published: July 2024

Subarachnoid haemorrhage (SAH) is a rare yet consequential medical emergency that may mimic an acute myocardial infarction (MI). SAH causes enhanced sympathetic activity, culminating in the development of neurogenic stunned myocardium (NSM), which presents as ST-segment deviations, prolonged QT intervals, T-wave inversions or Q-waves. Reperfusion therapy is contraindicated for SAH because of an increased risk of bleeding and death. Therefore, a prompt diagnosis is crucial. Here, we report a unique case of massive SAH presenting as diffuse ST-segment deviation simulating an acute MI. Our patient was brought to the emergency department after a cardiac arrest and died on day 2 of admission.
Language Delay in Children
Authors: Akpınar Funda , Çelik Pelin
Published: July 2024

Concerns about language development are among the most common complaints that parents seek medical advice regarding their children’s development. Developmental language disorder refers to a delay in children’s receptive or expressive language development without an underlying medical condition. Risk factors such as prematurity, low socioeconomic status, screen exposure, maternal depression and family history can affect language development in children. In a child presenting with a complaint of delay in language development, a detailed anamnesis should be taken, including developmental history, home environment, family history and psychosocial risk factors.
The evaluation of a child should include not only language development but also all areas of development (language, cognitive, motor, relationship, social-emotional) using a standatdized developmental assessment tool. A detailed physical examination should be performed to check for accompanying genetic, neurological and other medical conditions (e.g. cleft palate). Regardless of the result of newborn hearing screening, all children should undergo hearing tests, and if necessary, hemogram and iron parameters should be evaluated. If there is a history of regression, delay in the relationship area, or signs of accompanying neurudevelopmental problems, further evaluation should be performed. It should not be fogotten that a delay in language development may be the initial sign of problems such as cognitive delay, autism spectrum disoeder, hearing loss, and speech pronounciation disorder.
Early intervention shoul be planned for children with delayed language development and should not be waited for. Monitoring and supporting each child’s development with family-centered methods is the most effective method for the prevention, early diagnosis, and early intervention of all developmental difficulties, including delay in language development.
Discharging older patients from hospital to homecare: conflicts in collaborative practices among nurses across sectors
Authors: Hansen Mette Frier , Martinsen Bente , Galvin Kathleen , Norlyk Annelise
Published: July 2024

Background:

Collaboration is a key factor influencing the quality and safety in patients transition between sectors. However, specific collaborative practices may give rise to conflict between hospital nurses and community nurses.

Aims:

To gain a deeper understanding of collaborative practices which have the potential to fuel tension in collaboration between hospital nurses and community nurses during discharge of older patients from hospital to homecare.

Methods:

A meta-ethnography approach was used in this study and a systematic literature search was conducted in 2022.

Results:

Five themes were identified in the analysis. These themes revealed how uncertainty, limited confidence in information and personal attitude in communication may fuel tension between hospital nurses and community nurses. Tensions arising from a negative loop emerged because of uncertainty, causing a growing rift between hospital nurses and community nurses, leaving them as opponents rather than collaborators. The authors suggest that policy makers and managers can break this loop by underpinning shared policies and awareness of common objectives.
Falls prevention in older people and the role of nursing
Authors: Tiago Horta Reis da Silva
Published: July 2024

Falls among older individuals pose a significant public health challenge globally, impacting both individual wellbeing and healthcare systems. This article examines the importance of falls prevention in older people and the pivotal role of nursing in this domain. It presents statistics indicating the high prevalence of falls among older adults, highlighting their substantial impact on morbidity, mortality and healthcare costs. Furthermore, it discusses the multifactorial nature of fall risk factors, including age-related changes, chronic health conditions, medication use, impaired mobility, sensory deficits and environmental hazards. Nursing interventions encompass comprehensive assessments, personalised care plans, patient education and advocacy efforts aimed at reducing fall risks and enhancing safety. By addressing intrinsic and extrinsic factors contributing to falls, nurses contribute significantly to improving the quality of life for older adults and reducing the economic burden associated with fall-related injuries.
Dementia, comorbidity and multimorbidity
Authors: Pepper Amy , Dening Karen Harrison
Published: July 2024

Many people living with dementia will also have multimorbidity comprising several other intercurrent, long-term and comorbid conditions. This article examines the relationship between such conditions in the context of dementia, giving an overview of the literature, including prevalence and some of the common conditions that can coexist with dementia. The theory and evidence-base will be tied together using a case study approach, to illustrate the complexity of managing comorbid conditions and multimorbidity alongside dementia, and explore some of the approaches that can be used by community nurses to support the overall health of people living with dementia that they work with.
Tricks of the trade
Authors: Sandler Cara , Brooks Laura
Published: July 2024

Clinical relevance: Adjustments to the MIA removable quadhelix demonstrate how to derotate an upper right first molar.
Tricks of the trade
Authors: Naga Arza , Pranavi Jyotirmayi , Badavannavar Anand
Published: July 2024

Clinical relevance: This Trick shows how a single molar scissor bite or a crossbite can be corrected using a simple hook.
Finishing and detailing with the pre-adjusted edgewise labial fixed appliance: the why, the what and the how
Authors: Donovan Joey , McMorrow Siobhan , Salloum Erfan , Millett Declan T , McIntyre Grant T
Published: July 2024

Finishing and detailing is typically undertaken towards the end of orthodontic treatment. It should, however, be considered at the start of treatment and then evaluated at the end of each treatment stage. An appraisal of the disharmony between the planned and observed facial, skeletal and occlusal objectives is required with ongoing refinement to achieve the treatment goals. With the pre-adjusted edgewise labial fixed appliance, finishing and detailing may involve bracket repositioning, archform adjustment, localized wire bending, elastic traction, partial debonding, occlusal adjustment as well as restorative and periodontal input. It should also take into consideration the retention plan.

CPD/Clinical Relevance: This article summarizes what is involved in finishing and detailing with the pre-adjusted edgewise labial fixed appliance in regard to aesthetics, function and stability, and critiques the evidence available in relation to these aspects.
Proposal of National Intellectual Property Policy to Improve The Quality of University IP-education
Authors: Kim Dong-ha , Son Seung-woo
Published: July 2024

Intellectual property education has been established in universities nationwide for more than 10 years. Since 2012, intellectual property education leading university projects (2012-2023, 27 universities) had been operated with the support of the Korean Intellectual Property Office(KIPO) and the Korea Invention Promotion Association(KIPA), and intellectual property has been transplanted into the educational field and has grown in scale. However, in the creation of intellectual property (hereinafter referred to as IP), protection and utilization are fragmented according to the purpose of the result and systematic support and management are far off. In addition, IP-R&D to secure a strong IP portfolio through strategy establishment, technology development, and commercialization of corporate management is not so effective in the undergraduate curriculum of universities because IP is part of the curriculum or convergence major. Universities are playing a profound role in the development of the national industry and economy as a cradle of enhancing IP awareness and culture through intellectual property education, creatin g and utilizing IP, and fostering talents. This has considerable significance in terms of policy for establishing a master plan for national intellectual property. It is of paramount importance to raise awareness of intellectual property education at the national level and to establish the foundation for cultural diffusion. From a long-term point of view, IP-based multidisciplinary convergence and integrated education platforms can be established and reborn as a bridgehead for IP creation and utilization through the second phase of the IP education leading university project(tentative name “IP education leading university plus”) and “strengthening the university’s IP dedicated organization(OTC: Office of Technology Commercialization) capabilities.”
Three Very Short Histories of the Border: Regimes of In/visibility in the Bavarian Forest and Šumava National Parks
Authors: Huggan Graham , Šimková Pavla
Published: July 2024

Abstract: In this essay, we undertake three very short histories of the border in the Bavarian Forest and Šumava National Parks: multispecies histories in which human-animal relations are inextricably entwined. Our main argument is that national parks are multibordered phenomena, at once geopolitical and ecological systems that are neither fully open nor completely closed. We argue further that while some of these borders are visible, others are not, and that national parks can be used to make the case that invisible borders are in many ways as real and as powerful as visible ones and that their power—and its ecological as well as political significance—can be witnessed in two of Europe’s most iconic national parks. We first address the history of borders in the area the two national parks cover. The interplay between visible and invisible borders is evident across this history and requires seeing the borders in environmental, not strictly human, terms. So it is, too, in recent examples of nonhuman border-crossing on the part of scarcely visible creatures: bark beetles, whose periodic infestations have had significant political as well as environmental ramifications; and pathogens, which, in the case of the COVID-19 outbreak, have foregrounded international biosecurity issues revolving around the need to protect human lives from the proliferation of nonhuman life. Finally, we bring these three contexts together to show that borders—whether visible or invisible, whether material or ideational—have multispecies histories that we would do well to attend to: histories well illustrated in those complex political and ecological configurations that we call national parks.
All the Queen’s (White) Men: Figures and Limitations of Ecological Masculinity in Cheryl Strayed’s Wild
Authors: Rodewald Luke
Published: July 2024

Abstract: This article examines the recurring figures of ecological masculinities emergent in Cheryl Strayed’s Wild: From Lost to Found on the Pacific Crest Trail (2012). While previous scholarship has explored the ecofeminist themes inherent in the author’s account of her journey traversing the Pacific Crest Trail (PCT)—historically imagined as a predominantly male-dominated landscape—Strayed’s memoir also describes a significant number of male figures who seemingly embody what scholars Martin Hultman and Paul M. Pulé have recently termed “ecological masculinities,” which counter traditional Western conceptions of hegemonic masculinities as they relate to women and the nonhuman environment. Demonstrating a deep appreciation for nonhuman nature along with a sincere respect for Strayed’s explicitly, visible female status in this setting, such portrayals seem to suggest that the depth of an individual’s reverent relationship with the land parallels the capacity to transcend the hierarchal, misogynistic dispositions of traditional patriarchal ideologies. Using ecological masculinities as a lens to analyze Strayed’s memoir, this article explores the potentials and present limitations of this emergent theoretical conception. In particular, examining Wild through this framework incidentally exemplifies the current silence in the figuration’s considerations of race and ethnicity, especially how these factors correlate to an individual’s capacity to move toward a broader understanding and praxis of care. While both Strayed and the male hikers she meets on her quest may subvert conventional expectations bound to patriarchal views of gender and nature, questions of race, privilege, and access regarding outdoor recreation and wilderness lurk on the peripheries. As such, this article demonstrates that although theories of ecological masculinities represent an intriguing step toward alternatives to patriarchal “malestream” norms, such constructions must better account for racial considerations, which are inherently bound to discussions of masculinities.