bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of polyacene: exceeding the limits of benzene rings extension
Authors: Kitao Takashi , Miura Takumi , Nakayama Ryo , Tsutsui Yusuke , Chan Yee Seng , Hayashi Hironobu , Yamada Hiroko , Seki Shu , Hitosugi Taro , Uemura Takashi
Published: November 2022

The acene series, an important class of linearly polycyclic aromatic hydrocarbons, are of significant interest owing to their unique physicochemical features. With an increase in the number of fused benzene rings, acenes display an evolution of electronic structure and properties. Thus, tremendous efforts have been devoted to the synthesis of longer acenes, reaching dodecacene being the longest acene (12-fused benzene rings) reported to date. However, the formation of polymeric acenes with numerous benzene rings, namely polyacene (PA), has yet to be realized. Herein, we present a methodology for the synthesis of PA, as a long-sought-after compound, mediated by a metal−organic framework (MOF). Nanoconfined synthesis of precursor polymers in MOF channels and the subsequent dehydro-aromatization reaction produced PA that was overwhelmingly longer than the previously reported acenes. The scalable synthesis of PA could allow us to unveil the stability and electronic properties of PA, paving the way for their widespread applications in both the scientific and industrial fields.
Multi-objective optimization of thermoplastic CF/PEKK drilling through a hybrid method integrating NSGA-II and TOPSIS: an approach towards sustainable manufacturing
Authors: Ge Jia , Zhang Wenchang , Luo Ming , Catalanotti Giuseppe , Falzon Brian. G , Higgins Colm , Zhang Dinghua , Jin Yan , Sun Dan
Published: November 2022

Carbon-fibre-reinforced-polyetherketonketone (CF/PEKK) has attracted increasing interest in the aviation industry due to its self-healing/recycling properties. However, its machining performance is not well understood and there is a lack of optimization study for minimizing its hole damage and improving the production efficiency. Here, we report the first multi-objective optimization study for CF/PEKK drilling. A hybrid optimization algorithm integrating NSGA-II and TOPSIS is deployed to obtain the Pareto solutions and rank the multiple solutions based on closeness to ideal solutions. To highlight the impact of different matrix properties on the optimization outcome, comparative study with conventional thermoset CF/epoxy was carried out for the first time. Experimental validation shows the proposed method can achieve 91.5-95.7% prediction accuracy and the Pareto solutions effectively controlled the delamination and thermal damage within permissible tolerance. The vastly different optimal drilling parameters identified for CF/PEKK and CF/epoxy is attributed to the thermoplastic nature of CF/PEKK with unique thermal/mechanical interaction characteristics.
Osmotic pressure induced toxicity by aggregation of citrate-coated silver nanoparticles inside HepG2 cells
Authors: Ubaldo Pamela , Abshiro Henok , Cavender Franklin , Means Jay , Hales Dale , Wang Lichang
Published: November 2022

The effects of 10nm citrate-coated silver nanoparticles (AgNPs) to hepatocellular carcinoma (HepG2) cells were investigated to elucidate toxicity mechanisms. Cell viability, oxidative stress, protein expression, and cell morphology were assessed to determine the toxicity of AgNPs at various dose levels. 10nm citrate-coated AgNPs were found to be toxic to HepG2 cells at a dose of > 1.0 ppm and their LD50 was determined to be 3.0 ppm. Oxidative stress levels in the cells were found to increase with the dose of AgNPs and HepG2 cells can withstand high level of reactive oxygen species before cell death. The expressions of heat shock proteins and tubulin proteins were most significantly affected by the presence of AgNPs of 5.0 ppm. The AgNPs were observed to penetrate the cells treated with a dose of 5.0 ppm by transmission electron microscopy. Furthermore, the agglomeration of AgNPs in HepG2 cells was found and generated osmotic pressure that is likely another pathway to be responsible for the toxicity of AgNPs.
Neural Network Potentials for Accelerated Metadynamics of Oxygen Reduction Kinetics at Au-Water Interfaces
Authors: Yang Xin , Bhowmik Arghya , Vegge Tejs , Hansen Heine Anton
Published: November 2022

The application of ab-initio molecular dynamics (AIMD) for the explicit modeling of reactions at the solid- liquid interfaces can provide new understandings towards the reaction mechanisms. However, prohibitive computational cost severely restricts the time- and length-scale of AIMD. Equiv- ariant graph neural network (GNN) based accurate surrogate potentials can accelerate the speed of performing molecular dynamics after learning on representative structures in a data efficient manner. In this study, we combined uncertainty- aware GNN potentials and enhanced sampling to investigate the reactive process of the oxygen reduction reaction (ORR) at Au(100)-water interface. By using a well-established active learning framework based on CUR matrix decomposition, we can evenly sample equilibrium structures from MD simulations and non-equilibrium reaction intermediates that are rarely vis- ited during the reaction. The trained GNNs have shown excep- tional performance in terms of force prediction accuracy, the ability to reproduce structural properties, and the low uncer- tainties when performing MD and metadynamics simulations. Furthermore, the collective variables employed in this work en- ables an automatic search of reaction pathways and provide a detailed understanding towards the ORR reaction mechanism on Au(100). Our simulations identify an associative reaction mechanism where adsorbed O2 reacts with water to form hy- droxyls through an *OOH transition state. The reaction pro- ceeds without formation of *O with a low reaction barrier of 0.3 eV. The low barrier agrees with the fast reaction kinetics observed experimentally. The methodology employed in this study can pave the way for modeling complex chemical reac- tions at electrochemical interfaces with an explicit solvent at ambient conditions.
CO2-mineralization and carbonation reactor rig: design and validation for in situ neutron scattering experiments - Engineering and Lessons Learned
Authors: Mortazavi Ali , Song Fu V. , Michael Dudman Michael , Evans Michael J. , Copcutt Robert , Romanelli Giovanni , Demmel Franz , Farrar David H. , Parker Stewart F. , Tian Kun V. , Di Tommaso Devis , Chass Gregory A.
Published: November 2022

CO2 mineralization via aqueous Mg/Ca/Na-carbonate (MgCO3/CaCO3/Na2CO3) formation represents a huge opportunity for the utilization of captured CO2. However, large-scale mineralization is hindered by slow kinetics due to the highly hydrated character of the cations in aqueous solutions (Mg2+ in particular). Reaction conditions can be optimized to accelerate carbonation kinetics, for example by the inclusion of selected additives that promote competitive dehydration of Mg and subsequent agglomeration, nucleation and crystallization. Towards tracking mineralisation and these steps of the reaction, neutron scattering presents unprecedented advantages over traditional techniques for time-resolved in situ measurements. However, a setup providing continuous solution circulation to ensure reactant system homogeneity for industrially relevant CO2-mineralizsation was currently available for use on neutron beamlines. We therefore undertook the design, construction, testing and implementation of such a self-contained reactor rig for use on selected neutron beamlines at the ISIS Neutron and Muon Source (Chilton, UK). The design ensured robust attachment via suspension from the covering flange to stabilize the reactor assembly and all fittings, as well as facilitating precise alignment of the entire reactor and sample (test) cell with respect to beam dimension and direction. The assembly successfully accomplished the principal tasks of providing a continuous flow of the reaction mixture for homogeneity, quantitative control of CO2 flux into the mixture as well as temperature and pressure regulation throughout the reaction and measurements. The design is discussed, with emphasis placed on the reactor including its geometry, components and all technical specifications. Descriptions of the offbeamline bench tests, safety and functionality, as well as the installation on beamlines and trial experimental procedure are provided, together with representative raw neutron scattering results.
A Redox Transmetalation Step in Nickel-Catalyzed C-C Cou-pling Reactions
Authors: Green Kerry-Ann , Honeycutt Aaron , Ciccone Sierra , Grice Kyle , Petersen Jeffrey , Hoover Jessica
Published: November 2022

Ni-catalyzed C-H functionalization reactions are becoming efficient routes to access a variety of functionalized arenes, yet the mechanisms of these catalytic C-C coupling reactions are not well understood. Here we report the catalytic and stoichiometric arylation reactions of a nickel(II) metallacycle. Treatment of this species with silver(I)-aryl complexes results in facile arylation, consistent with a redox transmetalation step. Additionally, treatment with electrophilic coupling partners generates new C-C and C-S bonds. We anticipate that this redox transmetalation step may be relevant to other coupling reactions that employ silver salts as additives.
Synthesis of two quinolines from one substrate: The beginning of regulating the duality of free radicals
Authors: Jiao Runwei , Ren Xuhong , Li Xiheng , Sun Shitao , Zhu Hao , Lin Bin , Hua Huiming , Li Dahong , He Xinhua
Published: November 2022

Poly-substituted quinolines are scaffolds with diverse applications as pharmaceuticals, agrochemicals, electroluminescent materials, and dyestuffs. Herein, we present an effective scheme for the green synthesis of two multiply substituted quinoline derivatives from a singular substrate via regulating free-radical duality. Photo-catalytically generated imine radicals can undergo intramolecular Michael addition (nucleophilic 1,4-addition) to produce 3,4-disubstituted quinolines via a novel rearrangement in the presence of an inorganic base. Alternatively, they can react via an intramolecular anti-Michael addition (electrophilic 1,3-addition) in the presence of an organic base to furnish 2,3-disubstituted quinolines. The high-atom economy, good yields, mild reaction condition, simple experimental setup of this methodology, will prompt the development of Poly-substituted quinolines and other heterocycles synthesis via using intramolecular Michael addition and anti-Michael addition of free radicals. Moreover, our results suggests the theory that the electrophilic / nucleophilic bias of free radicals is determined by their structure is incomplete, the electrophilic/nucleophilic bias can be regulated by altering the reaction conditions, which can improve the efficiency of divergent synthesis.
DrosophilapVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes
Authors: Stanković Dimitrije , Csordás Gábor , Uhlirova Mirka
Published: November 2022

Post-transcriptional gene silencing using double-stranded RNA has revolutionized the field of functional genetics, allowing fast and easy disruption of gene function in various organisms. InDrosophila, many transgenic RNAi lines have been generated in large-scale efforts, including theDrosophilaTransgenic RNAi Project (TRiP), to facilitate in vivo knockdown of virtually anyDrosophilagene with spatial and temporal resolution. The available transgenic RNAi lines represent a fundamental resource for the fly community, providing an unprecedented opportunity to address a vast range of biological questions relevant to basic and biomedical research fields. However, caution should be applied regarding the efficiency and specificity of the RNAi approach. Here, we demonstrate that pVALIUM10-based RNAi lines, representing ∼13% of the total TRiP collection (1,808 of 13,410 pVALIUM TRiP–based RNAi lines), cause unintended off-target silencing of transgenes expressed from Gateway destination vectors. The silencing is mediated by targeting attB1 and attB2 sequences generated via site-specific recombination and included in the transcribed mRNA. Deleting these attB sites from the Gateway expression vector prevents silencing and restores expected transgene expression.
Ukrainian museography on the waves of censorship fluctuations (late 19th – early 20th centuries)
Authors: Cherhik Natalia
Published: November 2022

Purpose of the research: to reveal the specifics of the subordination of Ukrainian museography to the legislation of the Russian Empire with reference to information policy and the press.

Object of research: typographic designations, illustrations, texts of Ukrainian museographic works published in the Russian Empire in the late 19th – early 20th centuries.

The subject of the research: the process of passing the censorship of museum publications of the specified geographical segment and historical period.

Scientific novelty. The work for the first time comprehensively demonstrates the subordination of museographic publications of Ukrainian origin to the requirements of censorship legislation, which was in force in the Russian Empire during the late 19th – early 20th centuries.

Research methodology. Procedural aspects of the passage of censorship have been established based on the analysis of the official apparatus of the books. The release of Ukrainian museographic works is presented in three chronological blocks against the background of the legislative process on freedom of the press. Taking into account that additional restrictive censorship rules were in force in the Ukrainian provinces of the Russian Empire (the so-called «Valuevsky circular» of 1863 and «Emsky decree» of 1876), the textual and illustrative components of the editions were analyzed.

Relevance. The study of the process of overcoming legislative prohibitions on freedom of speech by Ukrainian museographers will make it possible in a qualitatively new way, through the prism of publishing, to assess the state and development of museums in Ukraine over the specified period.
Organization and holding the trial of Nazi criminals in Kharkiv (December 15-18, 1943)
Authors: Yakovlev Vitaliy
Published: November 2022

The issues of preparation and conduct of the Nuremberg Trials (1945-1946) have sufficiently fully and comprehensively covered in domestic and foreign historical, legal, and journalistic literature, while Kharkiv Trial 1943 (December 15-18, 1943) has remained outside the field of vision of scholars.

The purpose of the study is to highlight the issue of organizing and conducting the Kharkiv show trial over war criminals—servicemen of the Wehrmacht and the German police, as well as their collaborators.

The research methodology is based on the principles of historicism, objectivity, systematic scientific analysis and synthesis. The principle of historicism allows us to consider the issues of organizing and conducting the Kharkiv Trial in chronological sequence as a natural process that developed in accordance with the then sociopolitical situation and the global context. The objectivity of the study lies in the coverage and condemnation of the crimes of Nazism. Analysis and synthesis makes it possible to determine the role of the Kharkiv Tribunal in the process of forming international criminal legislation.

Scientific novelty of the research. During 1941-1943, the Soviet justice has formed a legal framework, which made it possible to hold trials of war criminals involved in the massacres of civilians and prisoners of war in the territory of the USSR. The agreements reached between Great Britain, the USA, and the USSR at the Moscow Conference (1943) were used by the Soviet government for the preparation of the show trial over the servicemen of Hitlerite Germany. During the Trial, the facts of the mass destruction of the civilian population and prisoners of war by the Nazis in the territory of Kharkivshchyna were established. The verdict of the Kharkiv Tribunal in practice has implemented the thesis, which became the cornerstone of international criminal law: «A crime committed by order of the high command does not exempt the perpetrator from criminal liability».

Conclusions. The Kharkiv Trial has become a legal precedent for the punishment of Nazi war criminals – German citizens, it has laid the foundations of international criminal law and given an acceleration in the decision to hold a trial of the main war criminals of Hitlerite Germany.

Keywords: Nazi war crimes, Main Directorate of Counter-Intelligence “SMERSH”, Military Tribunal of the 4th Ukrainian Front, show trial, Kharkiv Trial 1943, World War II.
Narrative Perspective of the School Trajectory of At-Risk Students
Authors: Bernárdez-Gomez Abraham , Barea Eva María González , Entrena María Jesús Rodríguez
Published: November 2022

Students’ engagement in the educational task has been a matter of growing interest over the past few years as a factor in tackling one of the leading academic problems, namely school dropout. This brief research report offers an overview of how engagement in the educational trajectories of young people at risk is manifested. It was studied by applying the life course theory as the backbone of the research. A qualitative methodology has been applied, using a biographical-narrative approach through semi-structured in-depth interviews. The total number of subjects interviewed was 10. The main results indicate that: a) there are stages in which events that facilitate positive or negative engagement predominate more strongly; b) in general, there is a higher presence of negative critical events that lead to a decline in the quality of the students' engagement; and c) there are a series of factors that stand out in each of the stages of the students' trajectories. One of the main conclusions that can be drawn is that the traineeships are dynamic and flexible. Students may have the possibility of returning to their studies.
DIGITAL TOOLS FOR COMPUTER PRESENTATIONS USED IN TEACHERS’ TRAINING
Authors:   University of Plovdiv „Paisiy Hilendarski“, Plovdiv, Velcheva Ivelina , Garov Kosta ,   University of Plovdiv „Paisiy Hilendarski“, Plovdiv
Published: November 2022

The following work is devoted to the appropriate digital tools for interactive computer presentations that could be used in the pedagogical specialists’ training. It is known that in last two years educational systems around the world have switched to online learning. This has led to a need for retraining of pedagogical specialists in the field of preparation of e-learning content. This is the main reason why it is important for teachers to know modern digital tools that provide various services related to cloud storage, video conferencing, creating presentations, building web content, creating mind maps, collecting and providing information, creating digital notebooks, working with a whiteboard, creating tests for control and assessment of knowledge and much more. This work presents two digital tools for innovative and attractive computer presentations and their practical application in teachers’ training. The described digital tools are used in the teachers’ training in bachelor’s and master’s programs of FMI at the University of Plovdiv „Paisii Hilendarski“, as well as in various qualification courses conducted by the Department of Qualification and Professional Development of pedagogical specialists at the same university.
Peran pemimpin transformasional membudayakan kerja etis guna meningkatkan organizational citizenship behaviour
Authors: Sari Santi Retno , Dewi Dita Nurul Aini Mustika , Digdowiseiso Kumba
Published: November 2022

Penelitian ini bertujuan menguji mediasi paralel dimensi iklim kerja etis pada hubungan kepemimpinan transformasional dengan organizational citizenship behavior (OCB) karyawan.  Penelitian ini memberikan kontribusi pada dukungan literatur kepemimpinan transformasional dengan mengajukan model mediasi paralel dimensi iklim kerja etis pada hubungan kepemimpinan transformasional dengan OCB. Penelitian ini merupakan penelitian asosiatif maka metode yang dipergunakan dalam penelitian ini adalah metode kuantitatif. Penelitian ini mengambil populasi karyawan di dua perusahaan di Jakarta. Ukuran sampel didasarkan dengan perhitungan rumus Yamane dan didapatkan 201 orang karyawan sebagai sampel. Teknik pengambilan sampel yang dipilih adalah metode probability sampling simple random sampling. Teknik analisis untuk pengujian mediasi paralel dengan menggunakan macro process yang dibantu dengan alat SPSS 26 dan Process V3.5. Hasil menunjukkan bahwa kepemimpinan tranformasional mempengaruhi secara positif dan signifikan pada OCB karyawan. Hasil pengujian pemediasian didukung dengan data yaitu secara keseluruhan iklim kerja etis memediasi hubungan kepemimpinan transformasional dengan OCB. Dan secara per dimensi, hanya dimensi review yang tidak memediasi pengaruh kepemimpinan transformasional terhadap OCB. Hasil ini mengungkapkan karyawan semakin meningkatkan perilaku kewargaannya bila didukung oleh pembudayaan iklim kerja etis terutama yang menampilkan ketiga dimensi yaitu kebersamaan, kesetaraan, dan keterbukaan. Selain itu karyawan akan semakin menampilkan perilaku kewargaan rela berkorban dengan adanya peningkatan penerapan gaya kepemimpinan yang menampilkan gaya transformasional. Implikasi praktis dan saran dikemukakan dalam penelitian ini.
Faktor-faktor pendorong intensi membeli produk vegan
Authors: Jordy Brian , Laksmidewi Dwinita
Published: November 2022

Vegetarian merupakan tren gaya hidup sehat yang sedang berkembang di dalam beberapa tahun ini. Penelitian ini bertujuan untuk menganalisis pengaruh environmental concern, healthy awareness, social influence, animal welfare, dan attitude toward consumption sebagai variabel mediasi dapat memengaruhi intensi membeli produk vegan di Jabodetabek. Penelitian ini mengambil sampel    penelitian sebanyak 130 orang responden vegetarian yang tinggal di Jabodetabek menggunakan teknik Purposive Sampling. Hasil penelitian menunjukan bahwa social influence dan animal welfare berpengaruh signifikan terhadap intensi membeli produk vegan.  Attitude toward consumption menjadi mediasi yang signifikan dalam pengaruh social influence dan animal welfare terhadap intensi membeli. Sedangkan environmental concern dan healthy awareness tidak berpengaruh signifikan terhadap intensi membeli produk vegan. Dan attitude toward consumption tidak dapat menjadi mediasi yang signifikan dalam pengaruh environmental concern dan healthy awareness terhadap intensi membeli. Bagi pemasar di industri vegan, hasil penelitian ini berimplikasi pada pentingnya edukasi konsumen mengenai kaitan kesehatan konsumen dan kesejahteraan hewan, dengan produk vegan.
Critical Incidents Scale for Ambulance Work ‐ Denmark (CISAW-D): the development of a screening tool for work exposure to critical events in operative ambulance personnel
Authors: Pihl-Thingvad Jesper , Vang Maria Louison , Møller Sara Rosenbeck , Hansen Nina Beck
Published: November 2022

Introduction: Critical incidents in ambulance work are not easily compared to other risk occupations. Understanding types of incidents that can be considered critical in operational ambulance work is important to prevent work-related post-traumatic stress (PTS).Aim:
This study aimed to develop a scale of critical incidents in ambulance work and assess its predictive validity in relation to the severity of PTS symptoms.Methods: A total of 1092 open-ended descriptions from Danish ambulance personnel were content analysed to develop a categorical
scale that identifies types of events perceived as critical to operative ambulance personnel. Multiple regression was used to assess whether the scale predicted PTS symptoms and to assess the cumulative effect of exposure to these events.Results: The study found that the 1092 descriptions
of critical events could be condensed into 28 categories of critical events. These ranged from life-threatening situations and deaths, to more daily events such as handling strong emotional reactions from patients’ relatives and working with terminally ill children. The frequency of
events significantly predicted the severity of PTS symptoms with low to moderate effect (std beta = 0.2, t(375) = 3.7, p < .001), even when adjusting for known risk factors for post-traumatic stress disorder.Conclusion: This study showed that critical events in ambulance work
included events that are not normally considered traumatic, and indicated that understanding the cumulative effect of these events is important when trying to prevent traumatic sequalae in ambulance personnel. The study highlighted the importance of increased focus on non-traumatic incidents
that have an ongoing impact on paramedics’ mental health and well-being. The Critical Incidents Scale for Ambulance Work ‐ Denmark (CISAW-D) is a promising tool for systematic screening for exposure to critical events in ambulance work.
A retrospective cohort study of pre-hospital agitation management by advanced paramedic practitioners in critical care
Authors: Brown Nick , Edwards Timothy , McIntyre Ian , Faulkner Mark
Published: November 2022

Introduction:Pre-hospital clinicians can expect to encounter patients with agitation, including acute behavioural disturbance (ABD). These situations carry significant risk for patients and emergency medical services. Advanced paramedics within the London Ambulance Service (LAS) are frequently tasked to these incidents. At present, little evidence exists regarding clinical decision-making and management of this patient group. We sought to explore the demographics of patients presenting with potential ABD and quantify the degree of agitation, physical restraint, effectiveness of chemical sedation and any associated complications.Methods:A retrospective analysis of pre-hospital clinical records for patients coded with ABD and attended by LAS advanced paramedics between 1 October 2019 and 30 September 2020. Sedation assessment tool (SAT) scores were used as the primary outcome measure.Results:A total of 237 patient records were identified. Of the patients, 147 (62%) were physically restrained and 104 (44%) were chemically sedated. Sedation was more commonly administered where patients were exposed to physical restraint. High SAT scores were associated with the administration of sedative agents and at higher doses. Of patients undergoing sedation, 89 (85%) had a SAT score reduction of 2 points or a final score ≤ 0. The mean SAT score reduction was 2.72. Three cases of minor injury were reported following physical restraint.Conclusion:Advanced paramedics undertook sedation in less than half the cohort, suggesting that other strategies such as communication and positioning were utilised. Most patients were managed into a state between being restless and rousable, largely negating the need for ongoing physical restraint during hospital transfer. Appropriately trained advanced paramedics can utilise sedation safely and effectively in selected cases.
KEDUDUKAN DAN KEWENANGAN RUMAH SAKIT UMUM DAERAH LANGSA SEBAGAI BADAN LAYANAN UMUM DALAM PERATURAN PEMERINTAH NOMOR 72 TAHUN 2019 TENTANG PERANGKAT DAERAH
Authors: Gusnally Harris , Yusrizal Yusrizal , Sulaiman Sulaiman
Published: November 2022

Peraturan Pemerintah Nomor 72 Tahun 2019 tentang Perubahan Atas Peraturan Pemerintah Nomor 18 Tahun 2016 tentang Perangkat Daerah mengatur rumah sakit Daerah dipimpin oleh direktur, sehingga perlu diatur mengenai batas waktu penyesuaian status jabatan direktur rumah sakit Daerah yang berdasarkan ketentuan sebelumnya dilaksanakan oleh pejabat fungsional dokter atau dokter gigi yang diberikan tugas tambahan. Selain itu dengan lahirnya Peraturan Pemerintah Nomor 72 Tahun 2019 tentang Perangkat Daerah bukan menjadi solusi yang baik untuk RSUD Langsa, melainkan memperumit masalah administrasi di berbagai bidang, oleh sebab itu dengan adanya PP NO. 72 Tahun 2019 menjadikan RSUD Langsa tidak lagi otonomi dalam mengelola rumah tangganya. Tujuan penelitian ini untuk mengidentifikasi dan menjelaskan kedudukan pembentukan Badan Layanan Umum Daerah Rumah Sakit Umum Daerah Langsa, dan untuk mengidentifikasi dan menjelaskan kewenangan Badan Layanan Umum Daerah Rumah Sakit Umum Daerah Langsa. Data diperoleh melalui penelitian kepustakaan (library research) dengan menggunakan beberapa pendekatan, diantaranya pendekatan konseptual (conceptual approach) dan pendekatan perundang-undangan (statute approach). Analisis data dilakukan secara preskriptif (Prescriptive analysis). Kedudukan pembentukan Badan Layanan Umum Daerah Rumah Sakit Umum Daerah Langsa mempunyai landasan hukum yang kuat hal ini dengan adanya Peraturan Menteri Dalam Negeri Nomor 61 Tahun 2007 tentang Pedoman Teknis Pengelolaan Keuangan Badan LayananUmum Daerah dan Pasal 68 ayat (4) Peraturan Walikota Langsa Nomor 16 Tahun 2012 tentang Pengelolaan Keuangan Badan Layanan Umum Daerah Rumah Sakit Umum Daerah Kota Langsa, perlu diatur Remunerasi Badan Layanan Umum Daerah Rumah Sakit Umum Daerah Kota Langsa. Kewenangan Badan Layanan Umum Daerah Rumah Sakit Umum Daerah Langsa  dalam pengelolaan keuangan dan barang milik daerah serta bidang kepegawaian bertanggungjawab kepada dinas yang menyelenggarakan urusan pemerintahan di bidang kesehatan, maka dalam hal ini otonomi yang diberikan kepada RSUD sebagai BLUD sendiri setelah keluarnya Peraturan Pemerintah Nomor 72 Tahun 2019 Perangkat Daerah, secara tidak langsung mempersempit gerak langkah administrasi yang cepat sesuai dengan kebijakan pelayanan yang dituntut untuk tetap professional dalam melayani masyarakat.Kata Kunci: Kedudukan, Kewenangan, Badan Layanan Umum
Improving community environmental literacy regarding the impact of mercury use in the artisanal small-scale gold mining sector (A study in Sumalata Timur District, North Gorontalo Regency, Gorontalo Province)
Authors: Maryati Sri , Lihawa Fitryane , Yusuf Daud , Pratama Muhammad Iqbal Liayong , Kasim Muh , Akase Noviar , Hubaib Nurmuhniyanti M.
Published: November 2022

This research focuses on villages where the community mostly works in the small-scale gold mining sector (ASGM), namely Hulawa Village and Buladu Village, North Gorontalo Regency. Mercury has remained being used by the community in this location for gold processing since a long time. It is important to increase the environmental literacy of the community around the ASGM area considering the dangers of mercury to health and the environment. This study aims to improve the environmental literacy of the community around ASGM regarding the mercury dangers to health and environment. Raising the community environmental literacy is carried out through a mercury dangers awareness campaign by playing videos of mercury dangers, distributing mercury-free gold processing leaflets, resources person explanation concerning mercury impact. Public knowledge about the dangers of mercury before and after the campaign was measured through questions. This study shows that there is a rise in the number of people who understand the dangers of mercury after a mercury awareness campaign. The increase in the number of people who understand the mercury dangers shows that audio-visual and printed media are effectively used to increase public awareness of the dangers of mercury in ASGM areas.
A METRÓPOLE MANAUS E A REESTRUTURAÇÃO PRODUTIVA EM MINIMERCADOS FRENTE À SITUAÇÃO DE PANDEMIA DA COVID19: ESTUDO DA ZONA LESTE DE MANAUS.
Authors: Ribeiro Beatriz Praia
Published: November 2022

A presente proposta identifica as transformações estruturais e econômicas de minimercados
situados na zona leste da cidade de Manaus, considerando o contexto da pandemia do novo
coronavírus e seus impactos na dinâmica urbana em sua área de influência. O recorte temático
escolhido para as reflexões diz respeito às adaptações estruturais que os pequenos
comerciantes, especialmente aqueles localizados em bairros periféricos na metrópole,
precisaram fazer em seus estabelecimentos, de modo a garantir sua sobrevivência diante da
reestruturação econômica e produtiva intensificadas pela situação da pandemia do novo
coronavírus. O movimento metodológico se dará pelo pensamento dialético lefebvriano de
espaço vivido, concebido e percebido por meio de uma revisão sistemática da literatura
científica proposta por Lefebvre (2006). Em sua tríade indissociável de análise espacial,
Lefebvre parte do pressuposto de que o espaço está para além de uma produção material, mas
articula-se concatenadamente às dimensões da vida humana, sua cultura, seu modo de ser,
tendendo a generalizar-se.
Acidentes Ofídicos e suas complicações clínicas: um estudo epidemiológico no Tocantins nos anos de 2015-2019
Authors: Araújo Rafael de Oliveira , Oliveira Matheus Reis de , Gonçalves Jane Augusto Guimarães
Published: November 2022

Os acidentes ofídicos têm importância médica em virtude de sua grande
frequência e gravidade. As consequências clínicas, físicas, psicológicas e as
perdas socioeconômicas dos acidentes ofídicos, seja contabilizando o número
de hospitalizações, o tempo de tratamento intra-hospitalar, óbitos ou invalidez
precoces, contribuíram para que tais emergências médicas fossem incluídas na
categoria de Doenças Tropicais Negligenciadas (DTNs). Observou-se uma
crescente anual de casos de 18,3% ao ano, representando aproximadamente 433
casos novos notificados por ano, sendo a região Médio Norte Araguaia (22,95%
dos casos) e a região Capim Dourado (20,73% dos casos), a faixa etária dos 20
aos 39 anos e o sexo masculino as variáveis mais acometidas. No que se refere
à gravidade dos casos notou-se que felizmente a imensa maioria dentem-se de
casos leves, 73,93% dos casos, e do total dos casos cerca de 93,45% evoluem para
cura. Dessa forma, espera-se contribuir com a implementação de futuras ações
públicas para que ocorra a redução da incidência deste agravo nos próximos
anos, melhorando a qualidade da saúde de sua população aliada.
História Global: definição e o estado da arte
Authors: Rizzo Aline Duarte da Graça
Published: November 2022

Neste texto, apresentamos elementos do debate sobre as bases da História Global, seus principais objetivos, desafios na academia em geral, bem como no caso particular da historiografia brasileira. (Palavras-chave: História Global, Historiografia Brasileira, História da Historiografia).
Memória, Segunda Geração de sobreviventes do Holocausto e Narrativa
Authors: Moreira Júlia Amaral Amato
Published: November 2022

Neste artigo, analisamos a literatura historiográfica especializada sobre memória coletiva e narrativas orais, relacionando-a com os estudos do Holocausto, afim de apontar a “segunda geração” como um caso de memória que possa ser estudado em particular. Dessa maneira, o conceito de Pós-memória é apontado como possibilidade teórica. (Palavras-chave: Memória Coletiva; Segunda geração; Narrativa).
TEOLOGIA E CIÊNCIAS NATURAIS: Aproximações e distanciamentos
Authors: Silva Itamar Marques da , Souza Waldir
Published: November 2022

O presente texto tem por objetivo apresentar as principais características da Teologia e das
Ciências Naturais, enquanto áreas do conhecimento científico, bem como, encontrar as
divergências e convergência existentes entre essas ciências. Este trabalho questiona: Como a
Teologia e as Ciências Naturais poderão dialogar, entre elas, para proporcionar respostas mais
abrangentes aos dilemas da sociedade? Para isso busca-se: Assinalar como a Teologia e as
Ciências naturais se constituem ciência; Descobrir pontos de divergências e convergências entre
elas; Reproduzir diálogos que possibilitem respostas abrangentes para sociedade. O texto
ocupa-se da metodologia qualitativa, descritiva e de revisão bibliográfica. É constatado que: há
grandes desafios para os teólogos e, também, para cientistas da área de ciências naturais, de
modo que superem a distância, conceitos limitados, fundamentalistas e, portanto, ignorâncias
que impossibilitam o agregar de saberes em uma proposta holística de interdisciplinaridade.
Determination of the in vivo activity of leaves extract of Zanthoxylum Chiloperone var. Angustifolium (Tembetary hú) orally and intralesionally administered to BALB/c mice experimentally infected with Leishmania
Authors: Elva Serna , Marisel Maldonado , Nilsa González
Published: November 2022

Natural products are becoming increasingly important as an unlimited source for obtaining chemical substances with possible pharmacological potential. Current existing drugs for the treatment of cutaneous leishmaniosis produce major side effects; therefore the search for new drugs is justified. The stem bark of Zanthoxylum Chiloperone var. Angustifolium Engl. (Rutaceae) is traditionally used in Paraguay for its antiparasitic properties. The leaf extract was evaluated for the first time to determine its leishmanicidal activity in BALB/c mice infected with amastigote forms of Leishmania amazonensis (PH8). The mice were treated orally with the extract at three concentrations (100, 50 and 10 mg/mL), intralesional (50 mg/mL), and subcutaneously using glucantime as a control (100 mg/mL). The percentage of decrease in parasite load was measured and with intralesional 50 mg/kg a reduction of 72% occurred, with the reference drug (Glucantime) a reduction of 62% was obtained with the same oral dose a reduction of 50%, while with an oral dose of 10 mg/mL the percentage of reduction was 55%. When the oral dose was increased to 100 mg/mL, the reduction percentage of the parasitic load was only 16%. These results indicated that the leaf extract of Z. chiloperone var. angustifolium Engl. at low oral concentrations (50 and 10 mg/mL) had very good activity against L. amazonensis, and it was even more efficacious intralesionally at 50 mg/mL but at the oral dose of 100 mg/kg has very reduced antiparasitic activity. This study showed the efficacy of the extract leaves of Z. chiloperone in reducing the parasite load in an in vivo test, so its use as a potential leishmanicidal could be suggested to develop and evaluate new drugs for the oral treatment of leishmaniosis disease with fewer side effects and lower cost.
ASPECTS THAT INTERVENE IN THE IMPLEMENTATION OF THE NEW PUBLIC MANAGEMENT
Authors: Popa Florina
Published: November 2022

Appeared in the last decades of the last century, against the background of economic and global developments, determined by the internationalization of production and free movement of capital, the New Public Management aimed to the transition from the bureaucratic principles of hierarchical setup, to the development of new practices of management . This change had to meet the requirements of the market economy, signifying another form of approach to administration and public management. The purpose of the changes was to reform the public sector organizations, increase their competitiveness and efficiency in the use of resources and the provision of services. The present study propose a short presentation of some opinions of theorists, regarding some limits and dysfunctions, which may occur in the application of the New Public Management, different from some successes of the changes accomplished. Other issues were also addressed, such as the occurrence of reversible trends in the reform process. Given the new challenges of society and the increased demands of citizens, the phenomenon requires efforts to find the best practices of the New Public Management, which to lead to the achievement of the proposed objectives. The research methodology used was the study and processing of ideas from foreign and domestic literature.
SOME ASPECTS REGRADING THE FUTURE OF FINANCIAL REPORTING
Authors: Botez Daniel , Enachi Mihaela
Published: November 2022

The financial reporting process is a standardized process by which an entity provides information about its business, which is not considered confidential, in the environment in which it operates, for the purpose of supporting and developing the society in general. For several years, this process has been undergoing a period of transformation that involves including in the reporting process, in addition to financial information, non-financial information that presents aspects of the resources used, the business model and the new value created by entity. Thus arose the concept of integrated reporting. In European Union, several European directives have been issued setting out the obligation to provide information on the environment, social issues, and personnel. Recently, a European Union project intended to amend the reporting directives by introducing a new concept, reporting for sustainability. These attitudes pose challenges for professional accountants as the reports need to be audited to express an opinion on the level of assurance in relation to the information provided.
RELATIVITY OF ACCOUNTING VALUES: CAUSES, CONSEQUENCES AND LIMITATION POSSIBILITIES
Authors: Enachi Mihaela , Botez Daniel
Published: November 2022

Accounting is influenced by a variety of historical, economic, cultural, and other non-accounting factors that led to different judgments in creating a system for representing the reality, the application of regulated requirements and the validation of the fidelity of the information in the annual financial statements, as a final product of accounting. In this article, we focus on the main determinants of the relativity of the values that characterize the events in the life of an organization, which can determine the different reporting of similar realities. Thus, we focus on the influence of taxation on accounting, on accounting policies and management decisions and the professional judgment in forming an opinion on the financial statements and we try to identify solutions to limit the relativity of the accounting values.
An Analysis of Speech Act on Civil War Movie
Authors: Mubarok Tyas Alhim , Nisak Winda Khoirun , Firmanda Yuliana
Published: November 2022

This research aims to analyze speech act found in Civil War movie. This research focuses on the conversation between Captain America and Iron Man. The method used in this research is qualitative using conversation analysis. The data were collected from conversation script between Captain America and Iron Man. The result of this research shows that in the conversation between Captain America and Iron Man. It was found that there are three kind of speech acts used between Captain America and Iron Man. They are locutionary, illocutionary, and perlocutionary acts. The most speech act frequently used is locutionary act with total number is 33 (46%). While the second speech act frequently used is illocutionary act that are 23 (33%). For perlocutionary act is only found 15 (21%). In locutionary act, the conversations consisted of rhetic and phatic act. Illocutionary act dominated by asking and answering and perlocutionary act involved sarcasm, joke and caution.
Dynamical Analysis of Ratio-dependent Predator-Prey Models with Prey Refuge and Optimal Harvesting on Both Populations
Authors: Robby Rizka Rizqi , Trisilowati Trisilowati , Darti I , Naharin S.N.
Published: November 2022

In this article, we discuss a dynamical analysis of ratio-dependent response predator-prey model with prey refuge and harvesting on both populations. Harvesting on predator and prey is used because both populations are assumed to have an economic value. In this model, it is also assumed that prey has an instinct to protect themselves from the threat of predators. The conducted dynamical analysis consists of determination of equilibria, existence conditions and their stability. Analytical results show that there are two equilibria: namely predator extinction point and the coexistence point which are exist and stable under certain condition. Furthermore, Pontryagin maximum principle is used to find optimal harvesting on predator and prey. Some numerical simulations are performed to illustrate the analytical result.
The Implementation of lndependent Curriculum Through Project Based Learning at TK ABA VII Kediri
Authors: Lestariningrum Anik , Rofiqoh Efi , Natanie Stella
Published: November 2022

The new paradigm of learning experiences dynamics along with the development of the world of education with increasingly complex and dynamic technology. These changes also impact the early childhood education environment, where playing as a way of learning will be strengthened again so that children are optimally fulfilled in all aspects of development. Moreover, the impact of the learning process during the Covid-19 pandemic resulted in the interruption of direct interaction with distance learning resulting in children lacking concentration and easily triggered by emotions. At the same time, early childhood is a fundamental period. The government also issued policies related to changes in learning in line with the new curriculum, namely the independent curriculum. Implementing an independent curriculum based on children's needs will be used to improve learning. This study aims to get an overview of the implementation of the independent curriculum at the Kindergarten level, especially in the city of Kediri. This study used a descriptive qualitative method with data collection techniques using observation, interviews, and documentation. Data analysis used descriptive analysis as a narrative that tells about the expected research objectives. The results of this study can be used as initial insight into how to implement an independent curriculum at the early childhood level, especially Kindergarten in the target school program for the first period, namely the age of 5-6 years.
Dirac Equation for Posch-Teller Potential in Radial Section Symmetry Spin Case using Asymptotic Iteration Method
Authors: Alam Yuniar , Hariyanto Yuanita Amalia
Published: November 2022

This study aims to determine the value of the energy spectrum and wave function for the Posch-Teller potential in the case of radial spin symmetry. The solution to the Dirac equation using the asymptotic iteration method is done by reducing the second-order differential equation to a hypergeometric type differential equation by means of variable substitution to obtain a relativistic energy equation. The relativistic energy of the system is calculated using matlab software. This study is limited to the case of spin symmetry in the radial section.
Contribution of Islamic Management In Building Ethics In Organizations
Authors: Saridin Rasman
Published: November 2022

Ethical misconduct and business scandals caused millions of dollars in losses, left behind damaged organizations, forced them to close their business and left thousands employees jobless without any future guarantee or security. This incident has left scholars and managers asking what role they might have played to curb these ethical scandals and what role they can play in the solutions. Scholar and managers collectively have responded to the ethical challenges that we face in organizational life. Some scholarship assesses the current state of ethics in management education, helping us to diagnose and tackle the realities of unethical behavior. Part of the solution to this problem is to design and develop courses and programs in a better way, integrate business and management learning with ethical conduct. Scholars should focus on which standards should be advanced. Indeed, what connects these diverse discussion is a clear recognition that educational components designed to solve the ethical quandaries we face will require a multifaceted and comprehensive approach. Religions and philosophical schools of thought have always played a significant role in the development of human values and behavior which has a great impact to business and corporate management. Research also suggests that the encouragement of religious principles in business can lead to benefits in the areas of creativity, honesty and trust, personal fulfillment, and commitment, which will ultimately lead to increased corporate and business performance. It is where Islamic Management come into place where the foundations, principles, and practices will give impact in developing ethical standard to organizations. Islamic Management will bring students and managers back to basic where they cannot put aside the role of religion in safeguarding management practices in organization.