bluuebunny/crossref_metadata_2025 huggingface dataset:
Selecting motivating repertoire for adult piano students: A transformative pedagogical approach
Authors: Coutts Leah
Published: June 2018

Selecting repertoire that adult piano students find motivating and musically satisfying is more complex than simply finding pieces that are aurally pleasing. Drawing on theories of motivation, adult learning and transformative pedagogy, this practitioner-based study describes how the author learned to involve her students in the selection process, to align repertoire with their tastes and goals, and to understand the impact of students’ values, expectations and perceptions of learning on their engagement with repertoire learned. It is hoped that the experiences and theories shared herein inspire teachers to reflect on their own pedagogical choices regarding repertoire selection.
Justifying music in the national curriculum: The habit concept and the question of social justice and academic rigour
Authors: Bate Elizabeth
Published: June 2018

In June 2015, the British government presented ‘the social justice case for an academic curriculum’ as the justification for recent radical changes to educational policy. However, this justification failed to account for both the key changes in the newly-revised National Curriculum for Music and the place of music in the National Curriculum as a whole.

Through a critical evaluation of the National Curriculum for Music, this study will propose how the place of music could successfully be justified within an education system wholly committed to ‘social justice’. Using the ‘habit concept’ of classical philosophical pragmatism, it will assess how and why music's educational value should be understood not through its ‘academic rigour’ but through its distinctive, inherently destabilising nature.
Minimum Sigma Set SR-UKF for Quadrifocal Tensor-based Binocular Stereo Vision-IMU Tightly-coupled System
Authors: Wang Maosong , Wu Wenqi , El-Sheimy Naser , Xian Zhiwen
Published: June 2018

This paper presents a binocular vision-IMU (Inertial Measurement Unit) tightly-coupled structure based on a Minimum sigma set Square-Root Unscented Kalman Filter (M-SRUKF) for real time navigation applications. Though the M-SRUKF has only half the sigma points of the SRUKF, it has the same accuracy as the SRUKF when applied to the binocular vision-IMU tightly-coupled system. As the Kalman filter flow is a kind of square-root system, the stability of the system can be guaranteed. The measurement model and the outlier rejection model of this tightly-coupled system not only utilises the epipolar constraint and the trifocal tensor geometry constraint between the consecutive two image pairs, but also uses the quadrifocal tensor geometry among four views. The structure of the binocular vision-IMU tightly-coupled system is in the form of an error state, and the time updates of the state and the state covariance are directly estimated without using Unscented Transformation (UT). Experiments are carried out based on an outdoor land vehicle open source dataset and an indoor Micro Aerial Vehicle (MAV) open source dataset. Results clearly show the effectiveness of the proposed new mechanisation.
On the mean field approximation of a stochastic model of tumour-induced angiogenesis
Authors: CAPASSO V. , FLANDOLI F.
Published: June 2018

In the field of Life Sciences, it is very common to deal with extremely complex systems, from both analytical and computational points of view, due to the unavoidable coupling of different interacting structures. As an example, angiogenesis has revealed to be an highly complex, and extremely interesting biomedical problem, due to the strong coupling between the kinetic parameters of the relevant branching – growth – anastomosis stochastic processes of the capillary network, at the microscale, and the family of interacting underlying biochemical fields, at the macroscale. In this paper, an original revisited conceptual stochastic model of tumour-driven angiogenesis has been proposed, for which it has been shown that it is possible to reduce complexity by taking advantage of the intrinsic multiscale structure of the system; one may keep the stochasticity of the dynamics of the vessel tips at their natural microscale, whereas the dynamics of the underlying fields is given by a deterministic mean field approximation obtained by an averaging at a suitable mesoscale. While in previous papers, only an heuristic justification of this approach had been offered; in this paper, a rigorous proof is given of the so called ‘propagation of chaos’, which leads to a mean field approximation of the stochastic relevant measures associated with the vessel dynamics, and consequently of the underlying tumour angiogenic factor (TAF) field. As a side, though important result, the non-extinction of the random process of tips has been proven during any finite time interval.
Copper-alloy Belts at Hasanlu, Iran: A Case Study in Hybridization and Heteroglossia in Material Culture
Authors: Cifarelli Megan , Castelluccia Manuel , Dan Roberto
Published: June 2018

The pitfalls of studying material outcomes of cultural contact as ‘hybrids’ have been well mapped, from essentialism to the echoes of eugenics. In archaeological research, attention to ‘hybrid’ products of cultural contact through assiduous tracing of ‘foreign’ elements to their points of origin has often yielded dubious claims regarding the nature of the interaction. For objects excavated in the Period IVb (1050–800bc) level at Hasanlu, this approach has led to assertions of ‘Assyrianization’, proclaiming the site the examplepar excellenceof the response to Assyrian cultural hegemony in the periphery. Through exploration of armoured sheet-metal belts found at Hasanlu, an artefact type introduced from the South Caucasus region and then produced locally, this paper considers the interpretive utility of the concept of ‘hybridization’—the transformative processes by which disparate visual elements, materials and ideas about the world react to and perturb each in a particular environment. We argue that through these processes, relocated exogenous objects and their endogenous counterparts communicate using multiple, even divergent, voices. This very multivocality, orheteroglossia, is instrumental in forging new social relationships and meanings.
Compassion-Focused Intervention for Highly Self-Critical Individuals: Pilot Study
Authors: Rose Alexandra , McIntyre Ruth , Rimes Katharine A.
Published: June 2018

Self-criticism is a transdiagnostic process associated with a range of psychological problems. This uncontrolled pilot study evaluated the feasibility and acceptability of a six-session intervention using methods from compassion-focused therapy to reduce self-criticism, as well as investigating changes in a range of outcome measures. Twenty-three university student participants with significant impaired functioning associated with high levels of self-criticism received six individual weekly treatment sessions and a 2-month follow-up appointment. Acceptability was assessed through participant feedback. The intervention appeared to be feasible in terms of recruitment and retention of participants, and participant feedback indicated that overall the intervention seemed acceptable. There were statistically significant improvements between pre- and post-intervention for self-criticism, functional impairment, mood, self-esteem and maladaptive perfectionism with medium to large effect sizes at both post-intervention and follow-up. Gains were maintained or increased between post-treatment and 2-month follow-up. The study showed preliminary evidence of effectiveness of a compassion-focused intervention for self-critical students which appeared to be a feasible and acceptable treatment approach. This intervention now requires investigation in a randomized controlled trial.
A domain-general monitoring account of language switching in recognition tasks: Evidence for adaptive control
Authors: STRUYS ESLI , WOUMANS EVY , NOUR SOUDABEH , KEPINSKA OLGA , VAN DEN NOORT MAURITS
Published: June 2018

Language switching experience is assumed to have an effect on domain-general control abilities in bilinguals, but previous studies on the relationship between these two variables have generated mixed results. The present study investigated the effects of bilingual experiences on the interaction between language switching and domain-general control. Thirty-two Dutch–French bilingual young adults executed a bilingual categorisation task to assess their language switching abilities and a Simon task to assess domain-general control. The results show that global response times on the Simon task were correlated to the forward switch cost (from L1 to L2); moreover, interestingly, the forward switch cost was found to be related to recent language exposure but not to the age of second language acquisition. We suggest a monitoring account of language switching to integrate the first finding with previous studies and we interpret the second finding as support for the adaptive control hypothesis.
Symmetries of bilingual language switch costs in conflicting versus non-conflicting contexts
Authors: LIU CONG , JIAO LU , WANG ZIYI , WANG MENGXING , WANG RUIMING , WU YAN JING
Published: June 2018

Previous studies have demonstrated that language switching in bilinguals can be affected by a number of variables, including the processing context. Here, we used a modified language-switching task combined with a Stroop paradigm, which manipulated the context of the task, to examine the impact of processing context on switch costs. The results of both Experiment 1 and Experiment 2 showed that the switch costs and the level of asymmetry in the switch costs are larger in the conflicting context than in the non-conflicting context, suggesting that the processing context affects the switch costs. In addition, the results of Experiment 2 revealed that individual variances in cognitive control capacity also play a role in the overall magnitude of the switch costs. Critically, processing context effects can be modulated by individual variance in cognitive control capacities. The results of this study are discussed within the framework of classic models of bilingual language control (e.g., the inhibitory control model).
MANY-VALUED LOGIC OF INFORMAL PROVABILITY: A NON-DETERMINISTIC STRATEGY
Authors: PAWLOWSKI PAWEL , URBANIAK RAFAL
Published: June 2018

Mathematicians prove theorems in a semi-formal setting, providing what we’ll call informal proofs. There are various philosophical reasons not to reduce informal provability to formal provability within some appropriate axiomatic theory (Leitgeb, 2009; Marfori, 2010; Tanswell, 2015), but the main worry is that we seem committed to all instances of the so-called reflection schema: B(φ) → φ (where B stands for the informal provability predicate). Yet, adding all its instances to any theory for which Löb’s theorem for B holds leads to inconsistency.

Currently existing approaches (Shapiro, 1985; Horsten, 1996, 1998) to formalizing the properties of informal provability avoid contradiction at a rather high price. They either drop one of the Hilbert-Bernays conditions for the provability predicate, or use a provability operator that cannot consistently be treated as a predicate.

Inspired by (Kripke, 1975), we investigate the strategy which changes the underlying logic and treats informal provability as a partial notion. We use non-deterministic matrices to develop a three-valued logic of informal provability, which avoids some of the above mentioned problems.
Brazilian Version of the Body Appreciation Scale (BAS) for Young Adolescents
Authors: Moreira Gabriela Salim Xavier , Lorenzato Luciana , Neufeld Carmem Beatriz , Almeida Sebastião Sousa
Published: June 2018

The present study developed a Brazilian adaptation of the BAS for young adolescents, testing its factor structure by the Confirmatory Factor Analysis (CFA), concurrent and criterion validity, and its internal consistency. Participants were 347 adolescents (171 male and 176 female, aged between 10 and 13 years old). Three psychologists experts in psychological evaluation and three teachers of Portuguese of elementary school also participated for the adaptation stage of the items in order to be properly understood by the sample age group. There were few changes from the version culturally adapted for the Brazilian adult population. Cronbach’s alpha coefficients were satisfactory for the general population and both sexes (.804; female =.851; male =.752). The one-factor model of the BAS was confirmed by the confirmatory factor analysis with good indicators for the measurements of adjustment to the model, χ2= 77.9; GFI = 0.967; NFI = 0.940, CFI = 0.979; TLI = 0.968; RMSEA;.038). The convergent validity analyzes revealed significant correlations between BAS scores and BMI (r= –.230;p< .001) and between the first and body image satisfaction (r = .309;p< .001). The BAS version for Brazilian young adolescents had adequate levels of validity and reliability, keeping the one-dimensional structure which indicates its use in Brazilian adolescent’s samples.
The Strengths and Difficulties Questionnaire -Dysregulation Profile, Non-Suicidal Self-Injury Behaviors and the Mediating Role of Stressful Life Events
Authors: Caro-Cañizares Irene , Díaz de Neira-Hernando Mónica , Pfang Bernadette , Baca-Garcia Enrique , Carballo Juan J.
Published: June 2018

Non-suicidal self-injury (NSSI) behaviors are self-injurious behaviors inflicted without intending death. Literature has shown the relationship between stressful life events (SLE) and NSSI behaviors. The Strengths and Difficulties Questionnaire-Dysregulation Profile (SDQ-DP) is defined as an index of self-regulatory problems, related to higher risk for suicidal ideation and attempts in adolescents. In this study the relationship between SDQ-DP and NSSI behaviors, mediated by SLE in a clinical sample of children and adolescents is analyzed. A cross-sectional study was conducted on 239 subjects (aged from 11 to 17) to test the mediation model. SDQ-DP significantly correlates with NSSI behaviors (Wald = 6.5477, p = .0105); SDQ-DP significantly correlates with SLE (T = 5.7229, p < .001); SLE significantly correlates NSSI behaviors, and the relation remains significant whilst controlling for SDQ-DP (Wald = 4.1715, p = .041); the relation between SDQ-DP and NSSI behaviors stops being significant whilst controlling for the potential mediator (SLE) (Wald = 2.9951, p = .0835). Study of indirect effect supports the mediation model (.0585 CI [.0016, .1266]). Findings are compatible with the complete mediation scenario. These results point out the importance of self-regulatory problems in coping strategies with regards to SLE and the development of NSSI behaviors.
Consensus and Conflict: A Content Analysis of American Party Platforms, 1840–1896
Authors: Silver Adam
Published: June 2018

Throughout the nineteenth century, political parties attempted to mediate local, state, and national conflicts to forge a winning electoral coalition. The question here is whether party leaders felt that success depended on offering clear divergent positions to their voters. In other words, to what extent did the parties present alternative programs to the electorate—at any specific time or over time? This study examines the growth of the two-party system in nineteenth-century America by focusing on the interaction of the elites of the Democrats and Whig/Republicans in forging their electoral message. The methodology includes a content analysis of national and state party platforms during presidential election years 1840 through 1896 to show when and where parties emphasized certain issue proposals. Ultimately, this is a story of interparty polarization—over time, the two major parties tended to emphasize the same issues and offer divergent positions in their platforms.
Temperature Response of Respiration Across the Heterogeneous Landscape of the Alaskan Arctic Tundra
Authors: Wilkman Eric , Zona Donatella , Tang Yanfei , Gioli Beniamino , Lipson David A. , Oechel Walter
Published: June 2018

Predictions of the response of ecosystem respiration to warming in the Arctic are not well constrained, partly due to the considerable spatial heterogeneity of these permafrost‐dominated areas. Accurate calculations of in situ temperature sensitivities of respiration (Q10) are vital for the prediction of future Arctic emissions. To understand the impact of spatial heterogeneity on respiration rates and Q10, we compared respiration measured from automated chambers across the main local polygonized landscape forms (high and low centers, polygon rims, polygon troughs) to estimates from the flux‐partitioned net ecosystem exchange collected in an adjacent eddy covariance tower. Microtopographic type appears to be the most important variable explaining the variability in respiration rates, and low‐center polygons and polygon troughs show the greatest cumulative respiration rates, possibly linked to their deeper thaw depth and higher plant biomass. Regardless of the differences in absolute respiration rates, Q10 is surprisingly similar across all microtopographic features, possibly indicating a similar temperature limitation to decomposition across the landscape. Q10 was higher during the colder early summer and lower during the warmer peak growing season, consistent with an elevated temperature sensitivity under colder conditions. The respiration measured by the chambers and the estimates from the daytime flux‐partitioned eddy covariance data were within uncertainties during early and peak seasons but overestimated respiration later in the growing season. Overall, this study suggests that it is possible to simplify estimates of the temperature sensitivity of respiration across heterogeneous landscapes but that seasonal changes in Q10 should be incorporated into model simulations.
Distinct patterns and processes of abundant and rare eukaryotic plankton communities following a reservoir cyanobacterial bloom
Authors: Xue Yuanyuan , Chen Huihuang , Yang Jun R , Liu Min , Huang Bangqin , Yang Jun
Published: June 2018

Plankton communities normally consist of few abundant and many rare species, yet little is known about the ecological role of rare planktonic eukaryotes. Here we used a 18S ribosomal DNA sequencing approach to investigate the dynamics of rare planktonic eukaryotes, and to explore the co-occurrence patterns of abundant and rare eukaryotic plankton in a subtropical reservoir following a cyanobacterial bloom event. Our results showed that the bloom event significantly altered the eukaryotic plankton community composition and rare plankton diversity without affecting the diversity of abundant plankton. The similarities of both abundant and rare eukaryotic plankton subcommunities significantly declined with the increase in time-lag, but stronger temporal turnover was observed in rare taxa. Further, species turnover of both subcommunities explained a higher percentage of the community variation than species richness. Both deterministic and stochastic processes significantly influenced eukaryotic plankton community assembly, and the stochastic pattern (e.g., ecological drift) was particularly pronounced for rare taxa. Co-occurrence network analysis revealed that keystone taxa mainly belonged to rare species, which may play fundamental roles in network persistence. Importantly, covariations between rare and non-rare taxa were predominantly positive, implying multispecies cooperation might contribute to the stability and resilience of the microbial community. Overall, these findings expand current understanding of the ecological mechanisms and microbial interactions underlying plankton dynamics in changing aquatic ecosystems.
Dissemination and persistence of extended-spectrum cephalosporin-resistance encoding IncI1-blaCTXM-1 plasmid among Escherichia coli in pigs
Authors: Abraham Sam , Kirkwood Roy N , Laird Tanya , Saputra Sugiyono , Mitchell Tahlia , Singh Mohinder , Linn Benjamin , Abraham Rebecca J , Pang Stanley , Gordon David M , Trott Darren J , O’Dea Mark
Published: June 2018

This study investigated the ecology, epidemiology and plasmid characteristics of extended-spectrum cephalosporin (ESC)-resistant E. coli in healthy pigs over a period of 4 years (2013–2016) following the withdrawal of ESCs. High carriage rates of ESC-resistant E. coli were demonstrated in 2013 (86.6%) and 2014 (83.3%), compared to 2015 (22%) and 2016 (8.5%). ESC resistance identified among E. coli isolates was attributed to the carriage of an IncI1 ST-3 plasmid (pCTXM1-MU2) encoding blaCTXM-1. Genomic characterisation of selected E. coli isolates (n = 61) identified plasmid movement into multiple commensal E. coli (n = 22 STs). Major STs included ST10, ST5440, ST453, ST2514 and ST23. A subset of the isolates belong to the atypical enteropathogenic E. coli (aEPEC) pathotype that harboured multiple LEE pathogenic islands. pCTXM1-MU2 was similar (99% nt identity) to IncI1-ST3 plasmids reported from Europe, encoded resistance to aminoglycosides, sulphonamides and trimethoprim, and carried colicin Ib. pCTXM1-MU2 appears to be highly stable and readily transferable. This study demonstrates that ESC resistance may persist for a protracted period following removal of direct selection pressure, resulting in the emergence of ESC-resistance in both commensal E. coli and aEPEC isolates of potential significance to human and animal health.
Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers
Authors: Yu Haiyang , Yin Shuangshuang , Zhou Shiyue , Shao Yingying , Sun Jiachen , Pang Xu , Han Lifeng , Zhang Yi , Gao Xiumei , Jin Chengyun , Qiu Yuling , Wang Tao
Published: June 2018

Magnolin is a multi-bioactive natural compound that possesses underlying anti-cancer properties. However, the mechanisms underlying remain to be elucidated. Here, we report the role of magnolin in suppressing human colorectal cancer (CRC) cells via activating autophagy and cell cycle arrest in vitro and in vivo. Pre-treatment of cells with specific autophagy inhibitor (3-methyladenine) or knockdown of endogenous LC-3B by siRNA significantly abrogates magnolin-induced cell cycle arrest. Molecular validation mechanistically shows that magnolin-induced autophagy and cell cycle arrest in CRC cells is correlated with decreased transcriptional levels of leukemia inhibitory factor (LIF), and we further find that inhibition of LIF decreases phosphorylation level of Stat3 and represses transcriptional expression of Mcl-1. Furthermore, magnolin-induced autophagy and cell cycle arrest suppress the growth of xenograft colorectal tumors without apparent toxicity. Finally, we evaluate the clinical correlation of LIF/Stat3/Mcl-1 in CRC patient tissues. As expected, LIF, p-Stat3, and Mcl-1 levels are high in CRC tissue but are scarcely found in normal colon tissue. High positive expressions of LIF or Mcl-1 are associated with poor prognosis. Doubly positive cases have shown the worst outcome. Taken together, our results have clarified a novel molecular mechanism whereby magnolin induces autophagy and cell cycle arrest through LIF/Stat3/Mcl-1 pathway in CRCs. Our results also have revealed that magnolin has a promising therapeutic potential in CRCs.
Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice
Authors: Harder Jeffrey M. , Williams Pete A. , Soto Ileana , Foxworth Nicole E. , Fernandes Kimberly A. , Freeburg Nelson F. , Libby Richard T. , John Simon. W. M.
Published: June 2018

The cJun N-terminal kinases (JNKs; JNK1, JNK2, and JNK3) promote degenerative processes after neuronal injury and in disease. JNK2 and JNK3 have been shown to promote retinal ganglion cell (RGC) death after optic nerve injury. In their absence, long-term survival of RGC somas is significantly increased after mechanical optic nerve injury. In glaucoma, because optic nerve damage is thought to be a major cause of RGC death, JNKs are an important potential target for therapeutic intervention. To assess the role of JNK2 and JNK3 in an ocular hypertensive model of glaucoma, null alleles of Jnk2 and Jnk3 were backcrossed into the DBA/2J (D2) mouse. JNK activation occurred in RGCs following increased intraocular pressure in D2 mice. However, deficiency of both Jnk2 and Jnk3 together did not lessen optic nerve damage or RGC death. These results differentiate the molecular pathways controlling cell death in ocular hypertensive glaucoma compared with mechanical optic nerve injury. It is further shown that JUN, a pro-death component of the JNK pathway in RGCs, can be activated in glaucoma in the absence of JNK2 and JNK3. This implicates JNK1 in glaucomatous RGC death. Unexpectedly, at younger ages, Jnk2-deficient mice were more likely to develop features of glaucomatous neurodegeneration than D2 mice expressing Jnk2. This appears to be due to a neuroprotective effect of JNK2 and not due to a change in intraocular pressure. The Jnk2-deficient context also unmasked a lesser role for Jnk3 in glaucoma. Jnk2 and Jnk3 double knockout mice had a modestly increased risk of neurodegeneration compared with mice only deficient in Jnk2. Overall, these findings are consistent with pleiotropic effects of JNK isoforms in glaucoma and suggest caution is warranted when using JNK inhibitors to treat chronic neurodegenerative conditions.
Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis
Authors: Guo Yuanxu , Min Zixin , Jiang Congshan , Wang Wei , Yan Jidong , Xu Peng , Xu Ke , Xu Jing , Sun Mengyao , Zhao Yitong , Hussain Safdar , Zhang Rui , Wang Quancheng , Han Yan , Zhang Fujun , Zhu Wenhua , Li Dongmin , Meng Liesu , Sun Jian , Lu Shemin
Published: June 2018

Osteoarthritis (OA) is the most common form of arthritis involving major structural changes of peripheral joints and local or systemic inflammation and in lack of therapeutic approaches because of complexity of underlying molecular basis. Our previous work showed that HS6ST2, an enzyme involved in the transfer of sulfate, is downregulated in cartilage tissues of OA patients compared with normal donors, but little is known about its regulatory mechanism. In this study, we demonstrated that the expression of HS6ST2 was lower in OA-damaged cartilage than smooth cartilage from the same patient. In chondrocytes, HS6ST2 could be targeted by miR-23b-3p, which was higher expressed in OA-damaged cartilage. Under TNF-α stimulation, the expression of HS6ST2 was found inversely correlated with the expression of miR-23b-3p. Downregulation of HS6ST2 regulated by overexpression of miR-23b-3p and siRNAs against HS6ST2 could enhance the protein level of MMP13 and aggravate the matrix degradation in chondrocytes. Increased expression of MMP13 depended on activity of p38 MAPK rather than total p38 MAPK level and was abrogated by HS6ST2 overexpression. Together, the results indicated that downregulated HS6ST2 targeted by miR-23b-3p promotes matrix degradation by activating p38 MAPK in chondrocytes and OA cartilage.
Scalable training of artificial neural networks with adaptive sparse connectivity inspired by network science
Authors: Mocanu Decebal Constantin , Mocanu Elena , Stone Peter , Nguyen Phuong H. , Gibescu Madeleine , Liotta Antonio
Published: June 2018

Through the success of deep learning in various domains, artificial neural networks are currently among the most used artificial intelligence methods. Taking inspiration from the network properties of biological neural networks (e.g. sparsity, scale-freeness), we argue that (contrary to general practice) artificial neural networks, too, should not have fully-connected layers. Here we propose sparse evolutionary training of artificial neural networks, an algorithm which evolves an initial sparse topology (Erdős–Rényi random graph) of two consecutive layers of neurons into a scale-free topology, during learning. Our method replaces artificial neural networks fully-connected layers with sparse ones before training, reducing quadratically the number of parameters, with no decrease in accuracy. We demonstrate our claims on restricted Boltzmann machines, multi-layer perceptrons, and convolutional neural networks for unsupervised and supervised learning on 15 datasets. Our approach has the potential to enable artificial neural networks to scale up beyond what is currently possible.
Carbon costs and benefits of Indonesian rainforest conversion to plantations
Authors: Guillaume Thomas , Kotowska Martyna M. , Hertel Dietrich , Knohl Alexander , Krashevska Valentyna , Murtilaksono Kukuh , Scheu Stefan , Kuzyakov Yakov
Published: June 2018

Land-use intensification in the tropics plays an important role in meeting global demand for agricultural commodities but generates high environmental costs. Here, we synthesize the impacts of rainforest conversion to tree plantations of increasing management intensity on carbon stocks and dynamics. Rainforests in Sumatra converted to jungle rubber, rubber, and oil palm monocultures lost 116 Mg C ha−1, 159 Mg C ha−1, and 174 Mg C ha−1, respectively. Up to 21% of these carbon losses originated from belowground pools, where soil organic matter still decreases a decade after conversion. Oil palm cultivation leads to the highest carbon losses but it is the most efficient land use, providing the lowest ratio between ecosystem carbon storage loss or net primary production (NPP) decrease and yield. The imbalanced sharing of NPP between short-term human needs and maintenance of long-term ecosystem functions could compromise the ability of plantations to provide ecosystem services regulating climate, soil fertility, water, and nutrient cycles.
Dispositional free riders do not free ride on punishment
Authors: Weber Till O. , Weisel Ori , Gächter Simon
Published: June 2018

Strong reciprocity explains prosocial cooperation by the presence of individuals who incur costs to help those who helped them (‘strong positive reciprocity’) and to punish those who wronged them (‘strong negative reciprocity’). Theories of social preferences predict that in contrast to ‘strong reciprocators’, self-regarding people cooperate and punish only if there are sufficient future benefits. Here, we test this prediction in a two-stage design. First, participants are classified according to their disposition towards strong positive reciprocity as either dispositional conditional cooperators (DCC) or dispositional free riders (DFR). Participants then play a one-shot public goods game, either with or without punishment. As expected, DFR cooperate only when punishment is possible, whereas DCC cooperate without punishment. Surprisingly, dispositions towards strong positive reciprocity are unrelated to strong negative reciprocity: punishment by DCC and DFR is practically identical. The ‘burden of cooperation’ is thus carried by a larger set of individuals than previously assumed.
Optimization of the structural characteristics of CaO and its effective stabilization yield high-capacity CO2 sorbents
Authors: Naeem Muhammad Awais , Armutlulu Andac , Imtiaz Qasim , Donat Felix , Schäublin Robin , Kierzkowska Agnieszka , Müller Christoph R.
Published: June 2018

Calcium looping, a CO2 capture technique, may offer a mid-term if not near-term solution to mitigate climate change, triggered by the yet increasing anthropogenic CO2 emissions. A key requirement for the economic operation of calcium looping is the availability of highly effective CaO-based CO2 sorbents. Here we report a facile synthesis route that yields hollow, MgO-stabilized, CaO microspheres featuring highly porous multishelled morphologies. As a thermal stabilizer, MgO minimized the sintering-induced decay of the sorbents’ CO2 capacity and ensured a stable CO2 uptake over multiple operation cycles. Detailed electron microscopy-based analyses confirm a compositional homogeneity which is identified, together with the characteristics of its porous structure, as an essential feature to yield a high-performance sorbent. After 30 cycles of repeated CO2 capture and sorbent regeneration, the best performing material requires as little as 11 wt.% MgO for structural stabilization and exceeds the CO2 uptake of the limestone-derived reference material by ~500%.
Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
Authors: Mao Kai , Quipildor Gabriela Farias , Tabrizian Tahmineh , Novaj Ardijana , Guan Fangxia , Walters Ryan O. , Delahaye Fabien , Hubbard Gene B. , Ikeno Yuji , Ejima Keisuke , Li Peng , Allison David B. , Salimi-Moosavi Hossein , Beltran Pedro J. , Cohen Pinchas , Barzilai Nir , Huffman Derek M.
Published: June 2018

Diminished growth factor signaling improves longevity in laboratory models, while a reduction in the somatotropic axis is favorably linked to human aging and longevity. Given the conserved role of this pathway on lifespan, therapeutic strategies, such as insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibodies (mAb), represent a promising translational tool to target human aging. To this end, we performed a preclinical study in 18-mo-old male and female mice treated with vehicle or an IGF-1R mAb (L2-Cmu, Amgen Inc), and determined effects on aging outcomes. Here we show that L2-Cmu preferentially improves female healthspan and increases median lifespan by 9% (P = 0.03) in females, along with a reduction in neoplasms and inflammation (P ≤ 0.05). Thus, consistent with other models, targeting IGF-1R signaling appears to be most beneficial to females. Importantly, these effects could be achieved at advanced ages, suggesting that IGF-1R mAbs could represent a promising therapeutic candidate to delay aging.
Out-of-equilibrium microcompartments for the bottom-up integration of metabolic functions
Authors: Beneyton Thomas , Krafft Dorothee , Bednarz Claudia , Kleineberg Christin , Woelfer Christian , Ivanov Ivan , Vidaković-Koch Tanja , Sundmacher Kai , Baret Jean-Christophe
Published: June 2018

Self-sustained metabolic pathways in microcompartments are the corner-stone for living systems. From a technological viewpoint, such pathways are a mandatory prerequisite for the reliable design of artificial cells functioning out-of-equilibrium. Here we develop a microfluidic platform for the miniaturization and analysis of metabolic pathways in man-made microcompartments formed of water-in-oil droplets. In a modular approach, we integrate in the microcompartments a nicotinamide adenine dinucleotide (NAD)-dependent enzymatic reaction and a NAD-regeneration module as a minimal metabolism. We show that the microcompartments sustain a metabolically active state until the substrate is fully consumed. Reversibly, the external addition of the substrate reboots the metabolic activity of the microcompartments back to an active state. We therefore control the metabolic state of thousands of independent monodisperse microcompartments, a step of relevance for the construction of large populations of metabolically active artificial cells.
Electron–electron interactions and the paired-to-nematic quantum phase transition in the second Landau level
Authors: Schreiber K. A. , Samkharadze N. , Gardner G. C. , Lyanda-Geller Y. , Manfra M. J. , Pfeiffer L. N. , West K. W. , Csáthy G. A.
Published: June 2018

In spite of its ubiquity in strongly correlated systems, the competition of paired and nematic ground states remains poorly understood. Recently such a competition was reported in the two-dimensional electron gas at filling factor ν = 5/2. At this filling factor a pressure-induced quantum phase transition was observed from the paired fractional quantum Hall state to the quantum Hall nematic. Here we show that the pressure-induced paired-to-nematic transition also develops at ν = 7/2, demonstrating therefore this transition in both spin branches of the second orbital Landau level. However, we find that pressure is not the only parameter controlling this transition. Indeed, ground states consistent with those observed under pressure also develop in a sample measured at ambient pressure, but in which the electron–electron interaction was tuned close to its value at the quantum critical point. Our experiments suggest that electron–electron interactions play a critical role in driving the paired-to-nematic transition.
Review of low-cost point-of-use water treatment systems for developing communities
Authors: Pooi Ching Kwek , Ng How Yong
Published: June 2018

For communities in developing countries, the majority of drinking water-related issues are due to pathogens from poor sanitation, resulting in infection and diarrhea. One cause of this is that these communities often do not have access to centralized water treatment facilities. Point-of-use (POU) systems are key solutions for treating water in developing communities; they are typically user-friendly, low cost, low maintenance, and grid-independent. Importantly, they treat and reduce the number of pathogens in water supplies, and many POU systems have been deployed and used by these communities, improving their livelihood. This review focuses on POU systems that cater to households or communities, with the aim to examine and evaluate technologies that have been implemented in POU systems in the past decade.
Transcriptome analysis of microRNA156 overexpression alfalfa roots under drought stress
Authors: Arshad Muhammad , Gruber Margaret Y. , Hannoufa Abdelali
Published: June 2018

Drought is one of the major abiotic stresses that negatively impact alfalfa growth and productivity. The role of microRNA156 (miR156) in drought has been demonstrated in plants. To date, there are no published studies investigating the role of miR156 in regulating global gene expression in alfalfa under drought. In our study, alfalfa genotypes overexpressing miR156 (miR156OE) exhibited reduced water loss, and enhanced root growth under drought. Our RNA-seq data showed that in response to drought, a total of 415 genes were upregulated and 169 genes were downregulated specifically in miR156OE genotypes. Genotypic comparison revealed that 285 genes were upregulated and 253 genes were downregulated in miR156OE genotypes relative to corresponding WT under drought. Gene Ontology enrichment analysis revealed that the number of differentially expressed genes belonging to biological process, molecular function and cell component functional groups was decreased in miR156OE genotypes under drought. Furthermore, RNA-Seq data showed downregulation of a gene encoding WD40 repeat in a miR156-specific manner. 5′ RACE experiments verified cleavage of WD40-2 transcript under drought. Moreover, alfalfa plants overexpressing WD40-2 showed drought sensitive, whereas those with silenced WD40-2 exhibited drought tolerant phenotypes. These findings suggest that miR156 improves drought tolerance in alfalfa by targeting WD40-2.
Three-Dimensional Anisotropic Magnetoresistance in the Dirac Node-Line Material ZrSiSe
Authors: Pan Haiyang , Tong Bingbing , Yu Jihai , Wang Jue , Fu Dongzhi , Zhang Shuai , Wu Bin , Wan Xiangang , Zhang Chi , Wang Xuefeng , Song Fengqi
Published: June 2018

The family of materials defined as ZrSiX (X = S, Se, Te) has been established as Dirac node-line semimetals, and subsequent study is urgent to exploit the promising applications of unusual magnetoresistance (MR) properties. Herein, we systematically investigated the anisotropic MR in the newly-discovered Dirac node-line material ZrSiSe. By applying a magnetic field of 3 T by a vector field, three-dimensional (3D) MR shows the strong anisotropy. The MR ratio of maximum and minimum directions reaches 7 at 3 T and keeps increasing at the higher magnetic field. The anisotropic MR forms a butterfly-shaped curve, indicating the quasi-2D electronic structures. This is further confirmed by the angular dependent Shubnikov-de Haas oscillations. The first-principles calculations establish the quasi-2D tubular-shaped Fermi surface near the X point in the Brillouin zone. Our finding sheds light on the 3D mapping of MR and the potential applications in magnetic sensors based on ZrSiSe.
Optical dispersion control in surfactant-free DNA thin films by vitamin B2 doping
Authors: Paulson Bjorn , Shin Inchul , Jeong Hayoung , Kong Byungjoo , Khazaeinezhad Reza , Dugasani Sreekantha Reddy , Jung Woohyun , Joo Boram , Lee Hoi-Youn , Park Sungha , Oh Kyunghwan
Published: June 2018

A new route to systematically control the optical dispersion properties of surfactant-free deoxyribonucleic acid (DNA) thin solid films was developed by doping them with vitamin B2, also known as riboflavin. Surfactant-free DNA solid films of high optical quality were successfully deposited on various types of substrates by spin coating of aqueous solutions without additional chemical processes, with thicknesses ranging from 18 to 100 nm. Optical properties of the DNA films were investigated by measuring UV-visible-NIR transmission, and their refractive indices were measured using variable-angle spectroscopic ellipsometry. By doping DNA solid films with riboflavin, the refractive index was consistently increased with an index difference Δn ≥ 0.015 in the spectral range from 500 to 900 nm, which is sufficiently large to make an all-DNA optical waveguide. Detailed correlation between the optical dispersion and riboflavin concentration was experimentally investigated and thermo-optic coefficients of the DNA-riboflavin thin solid films were also experimentally measured in the temperature range from 20 to 85 °C, opening the potential to new bio-thermal sensing applications.
Fundamental ingredients for discontinuous phase transitions in the inertial majority vote model
Authors: Encinas Jesus M. , Harunari Pedro E. , de Oliveira M. M. , Fiore Carlos E.
Published: June 2018

Discontinuous transitions have received considerable interest due to the uncovering that many phenomena such as catastrophic changes, epidemic outbreaks and synchronization present a behavior signed by abrupt (macroscopic) changes (instead of smooth ones) as a tuning parameter is changed. However, in different cases there are still scarce microscopic models reproducing such above trademarks. With these ideas in mind, we investigate the key ingredients underpinning the discontinuous transition in one of the simplest systems with up-down Z2 symmetry recently ascertained in [Phys. Rev. E 95, 042304 (2017)]. Such system, in the presence of an extra ingredient-the inertia- has its continuous transition being switched to a discontinuous one in complex networks. We scrutinize the role of three central ingredients: inertia, system degree, and the lattice topology. Our analysis has been carried out for regular lattices and random regular networks with different node degrees (interacting neighborhood) through mean-field theory (MFT) treatment and numerical simulations. Our findings reveal that not only the inertia but also the connectivity constitute essential elements for shifting the phase transition. Astoundingly, they also manifest in low-dimensional regular topologies, exposing a scaling behavior entirely different than those from the complex networks case. Therefore, our findings put on firmer bases the essential issues for the manifestation of discontinuous transitions in such relevant class of systems with Z2 symmetry.
Understanding tie strength in social networks using a local “bow tie” framework
Authors: Mattie Heather , Engø-Monsen Kenth , Ling Rich , Onnela Jukka-Pekka
Published: June 2018

Understanding factors associated with tie strength in social networks is essential in a wide variety of settings. With the internet and cellular phones providing additional avenues of communication, measuring and inferring tie strength has become much more complex. We introduce the social bow tie framework, which consists of a focal tie and all actors connected to either or both of the two focal nodes on either side of the focal tie. We also define several intuitive and interpretable metrics that quantify properties of the bow tie which enable us to investigate associations between the strength of the “central” tie and properties of the bow tie. We combine the bow tie framework with machine learning to investigate what aspects of the bow tie are most predictive of tie strength in two very different types of social networks, a collection of medium-sized social networks from 75 rural villages in India and a nationwide call network of European mobile phone users. Our results show that tie strength depends not only on the properties of shared friends, but also on non-shared friends, those observable to only one person in the tie, hence introducing a fundamental asymmetry to social interaction.
Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project
Authors: Martin-Trias Pablo , Lanteaume Laura , Solana Elisabeth , Cassé-Perrot Catherine , Fernández-Cabello Sara , Babiloni Claudio , Marzano Nicola , Junqué Carme , Rossini Paolo Maria , Micallef Joëlle , Truillet Romain , Charles Estelle , Jouve Elisabeth , Bordet Régis , Santamaria Joan , Jovicich Jorge , Rossi Simone , Pascual-Leone Alvaro , Blin Olivier , Richardson Jill , Bartrés-Faz David
Published: June 2018

Transcranial magnetic stimulation (TMS) can interfere with cognitive processes, such as transiently impairing memory. As part of a multi-center European project, we investigated the adaptability and reproducibility of a previously published TMS memory interfering protocol in two centers using EEG or fMRI scenarios. Participants were invited to attend three experimental sessions on different days, with sham repetitive TMS (rTMS) applied on day 1 and real rTMS on days 2 and 3. Sixty-eight healthy young men were included. On each experimental day, volunteers were instructed to remember visual pictures while receiving neuronavigated rTMS trains (20 Hz, 900 ms) during picture encoding at the left dorsolateral prefrontal cortex (L-DLPFC) and the vertex. Mixed ANOVA model analyses were performed. rTMS to the L-DLPFC significantly disrupted recognition memory on experimental day 2. No differences were found between centers or between fMRI and EEG recordings. Subjects with lower baseline memory performances were more susceptible to TMS disruption. No stability of TMS-induced memory interference could be demonstrated on day 3. Our data suggests that adapted cognitive rTMS protocols can be implemented in multi-center studies incorporating standardized experimental procedures. However, our center and modality effects analyses lacked sufficient statistical power, hence highlighting the need to conduct further studies with larger samples. In addition, inter and intra-subject variability in response to TMS might limit its application in crossover or longitudinal studies.
Directed Self-Assembly of Ge Quantum Dots Using Focused Si2+ Ion Beam Patterning
Authors: Chee See Wee , Kammler Martin , Graham Jeremy , Gignac Lynne , Reuter Mark C. , Hull Robert , Ross Frances M.
Published: June 2018

We show that templating a Si surface with a focused beam of Si2+ or Si+ ions can create suitable nucleation sites for the subsequent growth of self-assembled Ge quantum dots by chemical vapor deposition. To determine the mechanism of patterning we use atomic force microscopy to show that, similar to Ga+ patterning, the formation of a surface pit is required to enable control over Ge quantum dot locations. We find that relatively high implantation doses are required to achieve patterning, and these doses lead to amorphization of the substrate. We assess the degree to which the substrate crystallinity can be recovered by subsequent processing. Using in situ transmission electron microscopy heating experiments we find that recrystallization is possible at the growth temperature of the Ge quantum dots, but defects remain that follow the pattern of the initial implantation. We discuss the formation mechanism of the defects and the benefits of using Si ions for patterning both defects and quantum dots on Si substrates.