bluuebunny/crossref_metadata_2025 huggingface dataset:
YAP, CTGF and Cyr61 are overexpressed in tamoxifen-resistant breast cancer and induce transcriptional repression of ERα
Authors: Kim Hyungjoo , Son Seogho , Ko Yunhyo , Lee Jeong Eon , Kim Sangmin , Shin Incheol
Published: April 2021

About 70% of breast cancers overexpress estrogen receptor α (ERα, encoded by ESR1). Tamoxifen, a competitive inhibitor of estrogen that binds to ER, has been widely used as a treatment for ER-positive breast cancer. However, 20–30% of breast cancer is resistant to tamoxifen treatment. The mechanisms underlying tamoxifen resistance remain elusive. We found that Yes-associated protein (YAP; also known as YAP1), connective tissue growth factor (CTGF; also known as CCN2) and cysteine-rich angiogenic inducer 61 (Cyr61; also known as CCN1) are overexpressed, while ERα is downregulated in tamoxifen-resistant breast cancer. Inhibition of YAP, CTGF and Cyr61 restored ERα expression and increased sensitivity to tamoxifen. Overexpression of YAP, CTGF, and Cyr61 led to downregulation of ERα and conferred resistance to tamoxifen in ER-positive breast cancer cells. Mechanistically, CTGF and Cyr61 downregulated ERα expression at the transcriptional level by directly binding to the regulatory regions of the ERα-encoding gene, leading to increased tamoxifen resistance. Also, CTGF induced Glut3 (also known as SLC2A3) expression, leading to increased glycolysis, which enhanced cell proliferation and migration in tamoxifen-resistant cells. Together, these results demonstrate a novel role of YAP, CTGF and Cyr61 in tamoxifen resistance and provide a molecular basis for their function in tamoxifen-resistant breast cancer.
Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells
Authors: Bieerkehazhi Shayahati , Fan Ying , West Savannah J. , Tewari Ritika , Ko Junsuk , Mills Tingting , Boehning Darren , Akimzhanov Askar M.
Published: April 2021

Despite the recognized significance of reversible protein lipidation (S-acylation) for T cell receptor signal transduction, the enzymatic control of this post-translational modification in T cells remains poorly understood. Here, we demonstrate that DHHC21 (also known as ZDHHC21), a member of the DHHC family of mammalian protein acyltransferases, mediates T cell receptor-induced S-acylation of proximal T cell signaling proteins. Using Zdhhc21dep mice, which express a functionally deficient version of DHHC21, we show that DHHC21 is a Ca2+/calmodulin-dependent enzyme critical for activation of naïve CD4+ T cells in response to T cell receptor stimulation. We find that disruption of the Ca2+/calmodulin-binding domain of DHHC21 does not affect thymic T cell development but prevents differentiation of peripheral CD4+ T cells into Th1, Th2 and Th17 effector T helper lineages. Our findings identify DHHC21 as an essential component of the T cell receptor signaling machinery and define a new role for protein acyltransferases in regulation of T cell-mediated immunity.
Preface
Authors: Pedaste Margus , Kikas Eve
Published: April 2021

Eesti Haridusteaduste Ajakirja järjekordne erinumber keskendub üldpädevuste mõtestamisele, hindamisele ja arendamisele. Üldpädevused on juba pikemat aega kirjas Eesti põhikooli ja gümnaasiumi riiklikes õppekavades, kuid nende täpsemal määratlemisel, kirjeldamisel või taseme hindamisel ja seejärel üldpädevuste saavutamiseks sobivate tegevuste väljaarendamisel ja testimisel on veel palju uurida. Erinumbri artiklid kajastavad Eesti teadlaste uuringuid neil teemadel, aga toovad lugejateni ka essee sellest, kuidas matemaatika õppimine ja õpetamine vajaks ümbermõtestamist.
Üldpädevused gümnaasiumis
Authors: Mikser Rain
Published: April 2021

Käsiraamat "Üldpädevused gümnaasiumis" ilmus 2020. aastal Tartu Ülikooli väljaandena. Raamatu kuue peatüki keskmes on gümnaasiumi riiklikus õppekavas esitatud üldpädevused, eesmärk on aidata gümnaasiumiõpetajatel neid pädevusi mõista ja arendada. Peatükid sisaldavad pädevuste definitsioone riiklikus õppekavas, avavad pädevuste sisu rahvusvahelise teaduskirjanduse alusel ning kirjeldavad Eestis tehtud uuringuid üldpädevuste arendamise ja hindamise kohta. Raamat pakub arutlusainet nii riikliku õppekava rakendamiseks ja arendamiseks kui ka üldpädevustealase edasise uurimistöö kavandamiseks.
Tähelepanekuid ja mõtteid TLÜ artiklite kogumikku "Haridusmõte" lugedes
Authors: Krull Edgar
Published: April 2021

"Haridusmõte" (2020) on TLÜ kirjastuses sarja "Acta Universitatis Talliensis Educatio" esmaväljaandena ilmunud artiklite kogumik. Teos on pühendatud saja aasta möödumisele õpetajakoolituse algusest Tallinna Ülikoolis. Koostaja ja toimetaja on professor Mati Heidmets. Teos annab põhjaliku ülevaate arengust ja saavutustest pedagoogilise mõtte ja õpetajakoolituse valdkonnas. Raamatu 19 artiklit jaotatult nelja ossa käsitlevad haridusmõtte kujunemist Eestis, uurimusi hariduse eri astmetel alusharidusest kuni täiskasvanuõppeni, psühholoogia lõimimisvõimalusi kasvatusteadustega ning tulevikuvisioone uurimistulemuste rakendamisel koolipraktikasse. Et hariduse valkonnale on omane mõtteviiside ja lahenduste paljusus, kajastuvad siingi haridusmõtte ja -praktika probleemid, suuremal või vähemal määral nähtuna artiklite autorite silme läbi. Kuid selline "kallutatus" pole puudus, vaid pigem voorus, mis innustab "Haridusmõtte" lugejat probleemidesse paremini süüvima ja alternatiivseid lahendusi kaaluma.
The Role of Bak1 Methylation in the Induction of Chromosomal Aberrations under Chronic Low-Intensity External Radiation
Authors: Tsymbal O. , Isubakova D. , Bronikovskaya E. , Milto I. , Khalyuzova M. , Litviakov N. , Takhauova T.
Published: April 2021

Purpose: To study the relationship between the methylation status of the Bаk1 promoter and the frequency of chromosomal aberrations in human blood lymphocytes under chronic low-intensity external ionizing radiation.

Material and methods: The study was performed on 41 people (31 men and 10 women, aged from 36 to 83 years) who are former or current employees of the Siberian Group of Chemical Enterprises, who have been exposed or haven't been exposed to chronic low-intensity external radiation in the course of their professional activities. The workers included in the study were divided into two groups: the first – 15 people who did not have exposure, the second – 26 people who had external exposure (gamma radiation, total dose 89–716 mSv). Whole blood was used to isolate DNA and evaluate chromosomal aberrations in lymphocytes. The methylation status of the Bаk1 promoter was determined using methylsensitive PCR, which was performed after pretreatment of the isolated DNA with methylsensitive AoxI restrictase. The obtained quantitative data were analyzed using the Statistica 10. The differences were considered statistically significant at p ≤ 0.05.

Results: The methylation status of the Bаk1 promoter in the study groups does not differ (p = 0.18). The study of the effect of external radiation dose on the methylation status of the Bak1 promoter showed that the unmethylated promoter prevails in workers with an average radiation dose of 273.37 ± 43.82 mSv, while the methylated promoter – in workers with an average radiation dose of 183.63 ± 20.58 mSv (p = 0.03). The unmethylated promoter Bаk1 is associated with an increased frequency of chromatid fragments in the blood lymphocytes of group 2 workers (p = 0.03).

Conclusion: The status of methylation of the Bаk1 promoter in human blood lymphocytes under chronic low-intensity ionizing radiation does not change, but it is observed to depend on the radiation dose and is associated with an increased frequency of chromosomal aberrations (chromatid fragments). Thus, the unmethylated Bаk1 promoter prevails when the external radiation dose is increased. An increase in the frequency of chromatid fragments is associated with an unmethylated Bаk1 promoter. In addition, exposure to chronic low-intensity external radiation is accompanied by a decrease in the frequency of chromosomal fragments in the blood lymphocytes of workers of the Siberian Group of Chemical Enterprises.
Evaluation of Ultrahigh Dose Irradiation Sterilization Influence on Cytocompatibility of Decellularized Vascular Scaffolds
Authors: Brumberg V. , Astrelina T. , Kobzeva I. , Nikitina V. , Malivanova T , Usupzhanova D. , Brunchukov V. , Rastorgueva A. , Lischuk S. , Borbat A , Dubova E. , Ganzhelyuk M , Makhova A. , Karaseva T , Dobrovolskaya E , Lomonosova E. , Taratonenkova M , Bushmanov A. , Samoylov A.
Published: April 2021

Purpose: To study the effect of radiation sterilization at an ultra-high dose of 30 kGy on the cytocompatibility of decellularized vascular scaffolds repopulated with placenta MSCs.

Materials and methods: The material of the study were aortas of laboratory animals (rabbits and rats, three vessels for each animal species), which were subjected to detergent - enzymatic perfusion decellularization by two protocols differing in reagents composition. Then the scaffold decellularized by the most efficient protocol was irradiated at a dose of 30 kGy and repopulated with placenta MSCs. As a control, the unirradiated matrix was seeded with cells of the same type. Histological staining of hematoxilin – eosin, IHC for type I collagen and Ki67, DAPI staining and quantitative assessment of genomic DNA were used to evaluate the effectiveness of decellularization and seeding. Scaffolds seeding was assessed by analyzing serial sections taken on day 1st, 3rd, and 4th of culture.

Results: The scaffolds obtained in accordance with Protocol 1 were characterized by the absence of detectable cell nuclei, while the DNA content in them was significantly lower compared to Protocol 2. On the digitized images of sections of the unirradiated matrix, the cell nuclei were determined for routine H&E and DAPI staining while for the irradiated scaffold the cell nuclei were visualized on the border between the scaffold and fibrin gel only on DAPI stained section at 1st day of culture. The frequency of occurrence of Ki67+ nuclei on the 4th day of culture was significantly lower for the irradiated scaffold in comparison with the non-irradiated scaffold (7.5% and 29.8%, respectively, p=0.0054).

Conclusion: Scaffold irradiation leads to loss of cytocompatibility of tissue-engineering constructs.
STUDYING OF RADIATION SAFETY OF 188Re-LABELED MAA PREPARATION FOR TREATMENT OF RESISTANT SYNOVITIS
Authors: Lunev A , Klement'eva O. , Zverev A
Published: April 2021

The article is written about studying of radiation safety of 188Re-labeled microspheres of albumin preparation (hand mode) for treatment of resistant synovitis. The study material was a radiopharmaceutical based on albumin microspheres 5 –10 µm with rhenium-188 for treatment of resistant synovitis. The studying has led to conclusion the number of radiopharmaceutical portions prepared by one operator should not exceed 70 times a year, which will ensure that the main limits of equivalent doses to hands and skin with a reserve factor of 2 (250 μSv/h) are not exceeded. Protective equipment should be used to reduce doses to hands, as the most critical to operator's body part irradiation.
Prospects for the Development of Judicial Protection and Legal Regulation of the Provision of Radionuclide Diagnostics and Therapy for Vulnerable Groups of Citizens (Victims of Crime, Disabled People, Pensioners)
Authors: Andrusenko Sergey , Novikova R. , Ansheles Alexey
Published: April 2021

In Russia there is currently a great need for high-tech methods of radionuclide diagnostics and therapy. However, given the relatively small number of medical institutions that carry out radionuclide diagnostic and therapeutic methods, the provision of this type of medical care to vulnerable groups of citizens is of particular relevance. The absence of appropriate judicial and legal protection measures in case of failure to provide this type of high-tech assistance is a legislative gap.
Problem of the Relationship of the Developed Oncological Disease with Radiation in Conditions of Production
Authors: Galstyan I. , Nugis V. , Torubarov F. , Kukhta B. , Konchalovsky M. , Kretov A. , Bushmanov A.
Published: April 2021

Introduction.

Compensation programs for radiation-induced diseases in some foreign countries.

The data presented in UN documents.

The linkage between irradiation and certain diseases in the Russian Federation.

Conclusion.
ANALISIS PENGARUH CASH POSITION, DEBT TO EQUITY RATIO, DAN RETURN ON ASSETS TERHADAP DIVIDEND PAYOUT RATIO PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI
Authors: Gustian Hedi , Bidayati Utik
Published: April 2021

This study is performed to examine the effect of Cash Position, Debt to Equity Ratio (DER), Return on Assets (ROA), and toward Dividend Payout Ratio (DPR) in companies that is listed in Indonesian Stock Exchange over period 2006-2008.The population of this research is 387 company that listed in Indonesian Stock Exchange period 2006-2008. Sampling technique used here is purposive sampling on criterion (1) the company that represent their financial report per 2006-2008, and (2) the company that continually share their dividend period 2006-2008. The data is obtained based on Indonesian Capital Market Directory (ICMD 2009) publication. It is gained sample amount of 12 companies. The analysis technique used here is multiple regression with the least square difference and hypothesis test using t-statistic to examine partial regression coefficient and F-statistic to examine the mean of mutual effect with level of significance 5%.This research results that Cash Position, Debt to Equity Ratio, and (DER) Return on Asset (ROA) gives are not significantly positive effect on dividend payout ratio (DPR). We suggest for investors in Indonesian Stock Exchange whose purpose to gain dividend should be pay attention for informations that issued by the company, because with those information they can make the best decision for their investments. On this research, Return On Asset (ROA) shows the most influencing variable toward DPR that pointed by the amount of beta standardized coefficients value 1,130, DER are 0,096, and Cash Position are 0.030
PENGARUH KRISIS EKONOMI AMERIKA TERHADAP PASAR MODAL INDONESIA DILIHAT DARI ANALISIS LAPORAN KEUANGAN PERUSAHAAN
Authors: Ashshofia Rosetianie Kautsar , Sulistiyani Tina
Published: April 2021

This study aims to determine whether there are significant differences in the performance of mining companies listed in Indonesia Stock Exchange prior to and during the U.S. economic crisis seen from the analysis of financial statements of companies in 2004-2009. The population in this study were 22 mining companies. Using a purposive sampling technique obtained 10 samples of mining companies. The analysis tools kormogrov-smirnov to test normality of data, paired sample t-test to test normal distribution of data. Wilcoxon test to examine the data distribution is not  normal. The ratio shows a significant difference before the economic crisis America during the year 2004-2006 and the American economic crisis of 2007-2009 is the solvency ratio and the ratio of the activity. Ratio showed no significant differences before the   economic crisis America during the year 2004-2006 and the U.S. economic crisis in 2007-2009   is   the   liquidity   ratio, profitability ratios and market ratios.
ANALISIS PENGARUH HARGA, PELAYANAN, ATMOSFER KENYAMANAN, KERAGAMAN PRODUK, DAN DESAIN TOKO TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN (STUDI KASUS PADA GARDENA DEPARTMENT STORE)
Authors: Bahri Bahri , Muttaqiyathun Ani
Published: April 2021

One effort that may be company performed to improve the customer is to determine the price, service, comfort atmosphere, the diversity of products and store design is good and interesting. The purpose of this study, to examine the influence of price, service, atmosphere convenience, product diversity, and store design on consumer purchase decisions either partially or simultaneously. Techniques used in sampling in this study was purposive sampling. The number of samples used as much as 100 samples.Methods of analysis used to test the hypothesis that F Test and t-test. Measurement instruments used for the five independent variables are qualified validity and reliability.The results showed that the partial test results all independent variables (price, service, atmosphere convenience, product diversity, and store design) significantly influence consumer purchasing decisions. And test results together (F test) showed that all variables independent (X) has positive and significant impact on consumer purchasing decisions (Y).
ANALISIS PENGARUH DEBT TO EQUITY RATIO, CURRENT RATIO DAN RETURN ON INVESTMENT TERHADAP DIVIDEN PAYOUT RATIO PADA PERUSAHAAN MAKANAN DAN MINUMAN YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Huda Khoirul , Asakdiyah Salamatun
Published: April 2021

This research was aimed to know whether there was an influence of Debt to Equity Ratio (DER), Current Ratio (CR), Return on Investment (ROI) towards Dividend Payout Ratio (DPR) in food and beverage companies listed in Indonesian Stock Exchange of 2010-2012 periods. Populations in this research were 18 food and beverage companies listed in Indonesian Stock Exchange of 2010-2012 periods. Sampling technique used a Purposive Sampling. It obtained 10 companies entered in the criteria. The analysis technique used a panel data regression and a hypothesis test using t-test with trust level of 5%, Out of the three independent variables i.e. Debt to Equity Ratio (DER), Current Ratio (CR), Return On Investment (ROI), and Current Ratio (CR) significantly Dividend Payout Ratio (DPR). R-square value was 38.5%.
GOOD CORPORATE GOVERNANCE DAN RASIO HUTANG PERUSAHAAN
Authors: Runiati Novi , Sulistiyani Tina
Published: April 2021

The aim of this research is to investigate the influence of corporate governance, and firm size to leverage. Good corporate governance that used in this research is Corporate Governance Perception Index (CGPI). The independent variable that use in this research is leverage such as Debt to Total Aktiva and Debt to Total Shareholder Equity. The sample in this research are companies which were listed in Corporate Governance Perception Indeks in the year of 2010-2013 in SWA Magazine of publication. Total sample in this research are 11 companies that selected with purposive sampling method. This research uses multiple regression analysis method to investigate the influence of corporate governance and firm size to leverage. The results of this research indicate that good corporate governance had negative significant influence to debt to total aktiva and total shareholder equity. The firm size had no significant influence to debt to total aktiva and total shareholder equity.
PENGARUH KUALITAS PELAYANAN (ASPEK FISIK, KEANDALAN, INTERAKSI PRIBADI, PEMECAHAN MASALAH, DAN KEBIJAKAN) TERHADAP KEPUASAN KONSUMEN MIROTA KAMPUS DI YOGYAKARTA
Authors: Suryono Wisnu , Setyono Hendro
Published: April 2021

This study aims to determine whether that service quality dimension in the physical aspects, reliability, personal interaction, problem solving and policy affects customer satisfaction supermarket Mirota Campus in Yogyakarta and analyze the most dominant factor in influencing customer satisfaction Supermarket Mirota Campus. The population in this study are consumers/customers supermarket Mirota Campus. Samples taken as many as 300 respondents by using incidental sampling and purposive sampling. Based on the analysis of statistical data, indicators in this study are valid and are reliable variables. The sequence individually from each of the most influential variables is the variable with the problem-solving test value t for 5.608, the personal interaction with the t test value of 4.826, followed by policy variables with a value of 3.845 t test and physical aspects variables with the value of the t test for 2.595, whereas the lowest variable that is variable with a value of t-test reliability sebesar 1.886.
PENGARUH VARIABEL KEUANGAN PERUSAHAAN (RETURN ON ASSET, EARNING PER SHARE, CURRENT RATIO, DAN FINANCIAL LEVERAGE) TERHADAP UNDERPRICING
Authors: Maryoto Maryoto , Asakdiyah Salamatun
Published: April 2021

This research wa carried out on companies that do the Initial Public Offering (IPO) in the period 2008-2009. With a population of 31 companies and get a sample of 27 companies with the technique of sampling using purposive sampling. In this study tested the hypothesis by using multiple regression and t test. After doing an analysis of 27 companies in initial public offering in 2008 until 2009 are listed in Indonesia Stock Exchange, obtained the results of the calculation of the coefficient of determination (R2) obtained a value 0f 0.170 is in a position of positive mean return on assets (ROA), earning per share (EPS), current ratio (CR), and financial leverage (FL) 1.7% to explain underpricing. Thus 98.3% underpricing is explained by other variables not examined in this study. By using the t test for variable return on assets (ROA), earnings per share (EPS), current ratio (CR), and financial leverage (FL) had no significant influence on underpricing with the test results significantly greater value than the alpha (5%).
ANALISIS EFISIENSI PASAR MODAL SYARI’AH DAN KONVENSIONAL BENTUK LEMAH BURSA EFEK INDONESIA
Authors: Mujisukamto Aprinta Trisna , Sutanto Aftoni
Published: April 2021

The analysis in this study was to test the efficiency of the Indonesian capital market in the form of weak. this research has two objeactives, the first objectives is analyze whether Indonesia capital market (convensional and syari’ah) has been efficient (weak-form). The second one is to analyze differentiation efficient market between convensional and syari’ah capital market. This study uses monthly stock price data, from 23 conventional stocks included in the index LQ45 and 2 Islamic stocks included in the index during the observation period 2012-2013 JII. To test the hypothesis efficiency of capital markets weak form using the Run Test, this test is used to test randomness stock price changes. Results from this study are in the period 2012-2013 of conventional and islamic capital market is efficient in the weak form and analyze by looking for a random number of shares on the capital market conventional and islamic capital market, the results showed that there were 22 (95.7%) share price conventional random and 2 (100%) the share price of sharia are random. Based on the analysis of Islamic capital markets more efficient than the conventional capital market.
ANALISA KINERJA KEUANGAN PADA PERUSAHAAN METAL AND ALLIED PRODUCT YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Juniarti Juniarti , Asakdiyah Salamatun
Published: April 2021

The financial performance of companies known by analysing financial statements, the analysis conducted is the Current Ratio, Liquidity Ratio, Ratio of Current Assets Cash and Cash Ratio of Current Debt, Solvency Ratio of Total Debt for Equity and Debt Ratio of Assets, Ratio of Total Activity Assets Turnonver Ratio and Inventory Turnover Ratio, Profitability Ratio of Profit Margin Ratio and Return On Investment Ratio. This study used secondary data contained in the Indonesia Stock Exchange in the form of financial statement balance sheet and profit and loss of all three Metal and Allied Products Company for five years from 2005-2009. By using ratios – financial ratios above then the results is to provide ratings (ranking) on each – each company include: PT. Betonjaya Manunggal Tbk., rank (rank), the first based on the financial performance ratios liquidity ratios, solvency, activity, and profitability. PT. Lion Metal Works Tbk., rank (rank), second because one ratio is the ratio of the activity on the total asset turnover underperforming because fewer than than 1 times the velocity. PT, Jaya Pari Steel Tbk., rank (rank) third because in addition to the activity ratio, second ratio is the ratio of fluctuating liquidity and profitability ratios is not good.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI INDEKS HARGA SAHAM GABUNGAN DI BURSA EFEK INDONESIA PERIODE
Authors: Purwaningsih Dwi , Sulistiyani Tina
Published: April 2021

This study aims to determine the effect of the money supply, inflation, and SBI interest rates partially and simultaneously on the composite stock price index on the Indonesia Stock Exchange (BEI) in 2012-2014, the type of data and data sources used in this study are data secondary data from the Bank Indonesia Annual Report, the Indonesian Ministry of Trade Institute, and Exchange Corner Financial Data. To analyze the data of this study used a multiple linear regression analysis tool that aims to determine the effect of the money supply, inflation, and SBI interest rates on the Composite Stock Price Index using SPSS statistical tools. Based on this research, the research method used in the first hypothesis is the Statistical t test and the second is the Statistical F test. Based on the results of this study indicate that the variable Money Supply has a significant effect on the Composite Stock Price Index. For the inflation variable does not have a significant effect on the Composite Stock Price Index. And the SBI Interest Rate variable has a significant effect on the Composite Stock Price Index. Together these three independent variables (Amount of Money Supply, Inflation, SBI Interest Rates) have a significant influence on the dependent variable (Composite Stock Price Index).
PENGARUH DEBT TO EQUITY RATIO (DER), RETURN ON ASSET (ROA), DAN EARNING PER SHARE (EPS) TERHADAP PRICE TO BOOK VALUE (PBV) PADA PERUSAHAAN TELEKOMUNIKASI YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2009-2013
Authors: Suryaman Maman , Khoirunnisa Rikha Muftia
Published: April 2021

This study aims to analyze the effect of Debt to Equity Ratio (DER), Return On Assets (ROA), and Earning Per Share (EPS) on Price to Book Value (PBV). The sample used was a telecommunications company listed on the Indonesia Stock Exchange in the 2009-2013 period, in which there were six companies. The statistical method used is a multiple linear regression model. From the results of the Classical Assumptions test that is a test for normality, autocorrelation, multicollinearity, and heterosecdasticity, followed by multiple linear regression testing. The results showed that simultaneously (simultaneously) the variable Debt to Equity Ratio (DER), Return On Assets (ROA), and Earning Per Share (EPS) significantly influence the Price to Book Value (PBV) with a significance of 0,000. While partially only Debt to Equity Ratio (DER) with a significance of 0,000, Return On Assets (ROA) with a significance of 0,000 that significantly influence the Price to Book Value (PBV). While Earning Press hare has no significant effect on Price to Book Value (PBV) with a significance level of 0.273.
ANALISIS PENGARUH KUALITAS PELAYANAN KEPUASAN HARGA TERHADAP KEPUTUSAN PEMBELIAN SWALAYAN NABILA YOGYAKARTA
Authors: Dewanto Mega Ria , Asakdiyah Salamatun
Published: April 2021

Retail business in Indonesia has developed quite rapidly in the last few years with various forms and types. Competition in the retail or retail business which is currently increasingly fierce forces retail or retail business entrepreneurs to compete with each other to try to attract the attention of consumers. This study aims to determine and analyze the variables of service quality, satisfaction and price partially or jointly with purchasing decisions at the Nabila supermarket in Yogyakarta. In this study the sample used was a portion of Nabila Yogyakarta self-service consumers using Purposive Sampling techniques totaling 100 people. The analysis technique used is multiple linear regression analysis. The results of this study are that Service Quality has a positive and significant influence on the purchasing decisions of Nabila Supermarket customers in Yogyakarta with a regression coefficient of 0.409 (positive) and a tcount of 3.351 and a probability of error (p) = 0.001. Satisfaction variable has a positive and significant influence on the purchasing decisions of Nabila Supermarket customers in Yogyakarta with a regression coefficient of 0.249 (positive) and a tcount of 2.466 and p = 0.015. Price variable has a positive and significant influence on customer purchasing decisions in Nabila Yogyakarta with a regression coefficient of 0.336 (positive) and the significance test for the coefficient obtained is 3.751 and p = 0.000. Variable Service Quality, Satisfaction and Price simultaneously influence the customer purchasing decisions on users of Yogyakarta Nabila Supermarket with F statistics obtained by Fcount of 17.961 and the probability of error (p) = 0,000.
ANALISIS PENGARUH CUSTOMER EXPERIENCE TERHADAP PEMBELIAN ULANG (Studi Kasus pada Konsumen Restoran Gudeg Yu Djum Jln. Kaliurang Km. 5 Koncoran Gg. Sri Katon 2 Yogyakarta)
Authors: Zaenuri Muhamad , Sutanto Aftoni
Published: April 2021

This study aims to determine the effect of the repurchase of Gudeg Yu Djum restaurant. The sample used in this study amounted to 100 respondents, while the sampling method used was purposive sampling method. Data analysis method used is quantitative analysis using validity and reliability tests, F tests, coefficient of determination, t tests and multiple linear regression analysis. Analysis tools using multiple linear regression methods can be concluded that the sense variable has no significant effect on repurchases with a significance value (P value) of 0.840> 0.05, the feel variable has a significant effect on repeat purchases with a significance value (P value) of 0.007 <0 , 05, think variable has a significant effect on repurchase with a significance value (P value) of 0.005 <0.05, Act variable has no significant effect on repurchase with a significance value (P value) 0.945> 0.05, the relate variable has a significant effect on repurchase with a significance value (P value) 0.042 <0.05. Simultaneously sense, feel, think, act, and relate, significantly influence the repurchase with an F count of 22,010 with a significant number (P value) 0,000 <0.005. The coefficient of determination generated is 0.515, which means 51.5% change in the repurchase variable is explained by the variables sense, feel, think, act, and relate together, while the remaining 48.5% is explained by other variables not included in this research.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEPUTUSAN KONSUMEN ATAU NASABAH DALAM MEMILIH BANK SEBAGAI TEMPAT MENABUNG DI YOGYAKARTA
Authors: Widhiyanto Galih , Setyono Hendro
Published: April 2021

This study aims to determine the effect of multipurpose networks ATMs, interest, administrative fees, bank locations and bank services the customer's decision in choosing a bank as a place to save in Yogyakarta. In this study, taking a sample of residents who live in the city Yogyakarta with 60 respondents. This testing using analysis tools in the form of correlation (validity test) and reliability test for know the validity of the data used in research. To test the hypothesis in this research is multiple regression test. In the F test obtained F count (27.594)> F table (2.28) which means that together there is a significant influence between the variable services,  bank locations, multipurpose ATM networks, bank interest and administrative fees towards decisions. In the t test there are three variables that have no effect significantly to customer savings decisions, namely service variables with a value of t arithmetic (1.385) <t table (2.0057), Bank Location with a value of t arithmetic (1,933) <t table (2.0057) and Multipurpose And ATM Networks with calculated t values (0.839)  t table (2.0057) and administrative costs (3,510) > t table (2.0057). The results of this study provide evidence that 71.9% of customers' savings decisions influenced by the variable service, bank location, multipurpose ATM networks, bank interest and administrative costs while the remaining 28.1% influenced by other factors. Based on data analysis, the factors are a big influence on customer savings decisions is bank interest.
ANALISIS VARIABEL KUALITAS PELAYANAN TERHADAP KEPUASAN KONSUMEN PADA SWALAYAN CITROULI BABARSARI YOGYAKARTA
Authors: Shaputra Ade Ryan , Adhilla Fitroh
Published: April 2021

This study aims to determine and analyze variables quality of service (X) to customer satisfaction (Y), simultaneously or together with customer satisfaction at Citrouli Supermarket Babarsari in Yogyakarta. The sample used in this study totaling 100 respondents. The sampling method with using purposive sampling. Data analysis method used is a quantitative analysis using the validity test and test reliability, F test, coefficient of determination, t test and multiple regression analysis. By using the method of multiple linear regression analysis can be it was concluded that the physical aspect variables had a positive effect on consumer satisfaction with a B value of 0.080 and an increase of 1 unit then the value of the physical aspects increases by 0.080, the reliability variable is influential positive on consumer satisfaction with a B value of 0.231 and increases by 1 unit then the reliability variable increases by 0.231, variable personal interaction has a positive effect on customer satisfaction with B value of 0.159 and increased by 1 unit then the personal interaction variable increased 0.159, the problem solving variable has a positive effect on consumer satisfaction with a B value of 0.241 and increased by 1 unit then the variable customer satisfaction increases 0.241, the policy variable positive effect on customer satisfaction with a B value of 0.267 and increase by 1 unit, the policy variable increases by 0.267. The resulting determination coefficient is 0.572 yang means that 57.2% of customer satisfaction variables can be explained by variables Physical Aspects (X1), Reliability (X2), Personal Interaction (X3), Solving problems (X4) and Policies (X5) together, while the rest of 42.8% explained by other variables not contained in this research.
PENGARUH KEPEMIMPINAN, INSENTIF, DAN LINGKUNGAN KERJA TERHADAP LOYALITAS KARYAWAN ADMINISTRATIF KANTOR FAKULTAS DI UNIVERSITAS AHMAD DAHLAN YOGYAKARTA
Authors: Khoyrun Huda , Bidayati Utik
Published: April 2021

This study aims to determine the effect of leadership, incentives and work environment both partially and jointly on the loyalty of the administrative staff of the Faculty office at Ahmad Dahlan University, Yogyakarta. This research is a quantitative research. Data collection using a questionnaire method (questionnaire) that has been tested for validity and reliability, while data analysis is done using multiple linear regression analysis. The sample of this study was all administrative employees in all faculties at Ahmad Dahlan University, amounting to 60 employees with sample collection techniques using saturated samples, so the sample size in this study amounted to 60 employees. The results showed that: 1) Leadership has a significant effect on employee loyalty, this is indicated by the results of the t test of 3.123 with a significance of 0.003. 2) Incentives have a negative and significant effect on employee loyalty, this is indicated by the results of t count of -2,378 with a significance of 0.021. 3) The work environment has no effect on employee loyalty. 4) Leadership, incentives and work environment together have a significant effect on employee loyalty, this is indicated by an F count of 3.647 with a significance of 0.0.018 with a regression equation Y = -2.315 + 0.432X1-0.333X2 + 0.099X3 + e. With a large effect of 0.16.3%, while the remaining 83.7% is influenced by other independent variables that are not observed.
ANALISIS PENGARUH TINGKAT INFLASI, TINGKAT SUKU BUNGA, DAN NILAI TUKAR TERHADAP INDEKS HARGA SAHAM GABUNGAN (IHSG) DI BURSA EFEK INDONESIA (BEI) PERIODE 2013-2015
Authors: Primavistanti Daniar , Sutanto Aftoni
Published: April 2021

This research aimed to analyze and test the effect of inflation rates, interest rate and exchange rate  on the stok price index  at the stock exchange in 2013–2015. Independent variable used are inflation, interest rates, and exchange rates. While the dependent variable is the stock price index. The object of this research  is in the market listed  on the stock price index. The  inflation  rates, interest rates,  and  the  exchange  rate that  are  taken  from Indonesian Bank. The  analytical  method used is the classic assumption test and regression test. Based  on  the  survey  result revealed  that in partial  inflation and the exchange  rate does not  significantaly  influence the Stock  Exchange  Composite Index. While the variable interest rate significantly influence the Stock Exchange Composite Index. The test results simultaneosly show variable inflation, interest rates and exchange rates have an influence on the Stock Exchange  Composite Index. The coefficient of determination was 28,3%.
PENGARUH PROFITABILITAS, LIKUIDITAS, DAN UKURAN PERUSAHAAN TERHADAP KETEPATAN WAKTU PENYAMPAIAN LAPORAN KEUANGAN (STUDI EMPIRIS PADA PERUSAHAAN MANUFAKTUR SEKTOR INDUSTRI BARANG KONSUMSI YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2010-2014)
Authors: Damayanti Kartika , Fitriani Dyah
Published: April 2021

Timeliness of the submission of Go's financial statements public is important for disclosing accounting information used by market participants in the investment decision-making process. This study aims to find empirical evidence about the factors that are affect the timeliness of financial reporting of manufacturing sector companies the consumer goods industry which is listed on the Indonesia Stock Exchange. Factors tested in this study are return on assets, current ratio, and total assets. The population in this study is the Industrial Sector Manufacturing Company Consumer goods a total of 40 companies are then taken as many samples 28 companies use purposive sampling techniques. Analytical techniques used logistic regression with a confidence level of 5%. The results of the study shows that profitability has a significant effect on accuracy financial reporting time, whereas liquidity and company size are not significantly influence the timeliness of financial reporting.
PENGARUH VARIABEL FUNDAMENTAL TERHADAP HARGA SAHAM PERUSAHAAN GO PUBLIC DI BURSA EFEK INDONESIA (Studi pada Perusahaan Sub Sektor Batu Bara Pertambangan yang Terdaftar di Bursa Efek Indonesia Periode 2013-2016)
Authors: Anisa Anisa , Asakdiyah Salamatun
Published: April 2021

This study aims to determine the effect of liquidity (Current Ratio), leverage (Debt to Equity Ratio), profitability (Return on Equity) to the price of shares of mining coal companies listed on the Indonesia Stock Exchange in the period 2013-2016. The dependent variable used is the stock price, while the independent variable is liquidity (Current Ratio), leverage (Debt to Equity Ratio), and profitability (Return on Equity). The population in this study is a coal mining company listed on the Indonesia Stock Exchange as many as 22 companies and then taken as many as 8 companies. The analysis technique used is the classic assumption test, panel data regression analysis with a 5% confidence level, hypothesis testing is performed using the t test and F test. The results of this study indicate that liquidity (Current Ratio) has no significant effect on stock prices, with a probability value of 0.980 is greater than α 0.05. leverage (Debt to Equity) has no significant effect on stock prices, with a probability value of 0.386, greater than α 0.05. and profitability (Return on Equity) have no significant effect on stock prices with a probability value of 0.343 greater than α 0.05. While simultaneous variable liquidity (Current Ratio), leverage (Debt to Equity Ratio), and profitability (Return on Equity) have no significant effect on stock prices with a prob value (F-statistic) of 0.662 greater than α 0.05. The coefficient of determination of 0.050 or 5% means the stock price is influenced by liquidity (Current Ratio), leverage (Debt to Equity Ratio), and profitability (Return on Equity) by 5% while the remaining 0.950 or 95% is influenced by other variables outside the research variable.
REAKSI SAHAM INDEKS JII TERHADAP PENGUMUMAN RESHUFFLE KABINET KERJA TAHUN 2015 DI BURSA EFEK INDONESIA
Authors: Arviani Herizka Ayuk , Khoirunnisa Rikha Muftia
Published: April 2021

This study aims to determine the speed of JII stock price reaction on the Indonesia Stock Exchange around the date of the announcement of the Working Cabinet reshuffle and to analyze the difference in average trade volume in the period before and after the announcement of the Working Cabinet reshuffle. This data collection technique uses population techniques taken by 30 companies in the JII Index for the period June - November 2015 with observation period 10 days before and 10 days after the announcement. Analysis tools that are used to determine the reaction of stock prices before and after using one sample t test while the analytical tool to distinguish the average trading volume using paired sample t test using an alpha level (α) of 10%. The results of the analysis of stock price reactions indicate that there is a JII stock price reaction at Indonesia Stock Exchange in the period before and after the announcement of the Working Cabinet reshuffle. Because abnormal returns occur at H-7, H-4, H-1, H0, H + 1, H + 7 and H + 10. And the results of the average volume test that is there is a difference in the average trading volume before and after the announcement of the Working Cabinet reshuffle. This can be seen from the significance value lower than alpha 10% (0.033 <0.0.1).
PENGARUH CURRENT RATIO, RETURN ON EQUITY, DAN DEBT TO EQUITY RATIO TERHADAP HARGA SAHAM (Pada Perusahaan Konstruksi di Bursa Efek Indonesia Periode 2015-2017)
Authors: Fiqih Bhekti Ainul , Merdiana Candra Vionela
Published: April 2021

This study aims to determine the effect of Current Ratio (CR), Return On Equity (ROE) and Debt to Equity Ratio (DER) on stock prices. Current Ratio is the liquidity ratio, Return On Equity is the profitability ratio and the Debt to Equity Ratio is the Solvency ratio. The object in this study is a Construction Company listed on the Indonesia Stock Exchange (IDX). The research method in this study is a documentation method with a quantitative approach. The population used amounted to 26 companies, then the determination of the sample was determined through a purposive sampling technique. Based on predetermined2 criteria, a sample of 14 companies was obtained. The results showed that simultaneously the Current Ratio (CR), Return On Equity (ROE) and Debt to Equity Ratio (DER) variables had a significant effect on stock prices. Partially, Current Ratio (CR) has a positive but not significant effect on stock prices, while Return on Equity (ROE) has a positive and significant effect on stock prices and Debt to Equity Ratio (DER) has a negative and significant effect on stock prices. This shows that the company must maintain the value of Return On Equity (ROE) and Debt to Equity Ratio (DER).
PENGARUH BUDAYA ORGANISASI, KOMUNIKASI DAN LINGKUNGAN KERJA TERHADAP KEPUASAAN KERJA KARYAWAN UNIVERSITAS AHMAD DAHLAN YOGYAKARTA
Authors: Sari Tunjung Santika , Bidayati Utik
Published: April 2021

This study aims to determine the effect of organizational culture, communication and work environment on job satisfaction of Ahmad Dahlan University employees. In this study the population used was faculty administration employees who have an accreditation study program totaling 65 people. The sample used was 65 respondents using the saturated sampling method. The analysis technique used is multiple regression analysis. Hypothesis testing using t test shows that organizational culture has no effect on employee job satisfaction while communication and work environment influence on job satisfaction. Then through the F test shows that organizational culture, communication and work environment simultaneously affect job satisfaction.
PENGARUH HARGA, KUALITAS PRODUK, DAN KUALITAS PELAYANAN TERHADAP KEPUTUSAN PEMBELIAN (STUDI KASUS PADA WARUNG SATE KLATAK PAK PONG BANTUL)
Authors: Adhitama Muhammad Hendri , Sukardi Sukardi
Published: April 2021

This study aims to analyze the influences of prices, quality of products and services on purchasing decision in Pak Pong Klatak Satay Culinary in Bantul. The subjects of this research were customers of Pak Pong Klatak Satay Culinary in Bantul. The population of the study were people who purchased products of Pak Pong Klatak Satay Culinary in Bantul.  The samples were determined by accidental sampling method by total of 80 respondents. Data were collected by giving a list of questions / questionnaires to  respondents dealing with prices, products quality as well as services quality and how they influence the customers decision in purchasing the products. This study used a multiple linear regression analysis technique. The researcher tested the hypothesis using T test and F test. The test results  showed that prices have a positive but insignificant influence, products quality has a negative and insignificant influence. Meanwhile, services quality has a positive and significant influence. Prices, products and services quality contribute  to a simultaneously positive and significant influence upon customer’s purchasing decision as the significant value of 0,000 is smaller than 0,5. The prices variables, products quality and services quality are able to explain the purchasing decision variable in Pak Pong's klatak satay culinary at 35%  and  the  remaining 65% explained by other variables not included in the study.
KUALITAS PRODUK DAN KUALITAS PELANAN SEBAGAI ANTASEDEN KEPUASAN PELANGGAN DALAM MEMBENTUK LOYALITAS PELANGGAN (Studi Pada Pelanggan Waroeng Spesial Sambal “SS” Cabang Veteran Yogyakarta)
Authors: Mulyana Alo Rahmawati , Setyono Hendro
Published: April 2021

The aim of study is to  analyze about effect  product  quality  and  service  quality  on customer’s satisfaction to build customer’s loyalty at Waroeng Spesial Sambal “SS” in the branch of Veteran Yogyakarta. Population in this study are all consumers who make  purchases at Waroeng Spesial Sambal “SS” the branch in the  branch of Veteran Yogyakarta. While the sample  in  this  study  is a portion of consumers who have  made  purchases at least twice in the past year. The sampling technique uses purposive sampling. The data  used in this study is primary data. The number  of studies  in  this  study were  sixty  samples  in  the  city of Yogyakarta which  were processed  using  multiple linear regression  analysis  and mediation analysis  using SPSS 20 for windows. The results of the analysis in this study are: product quality dosen’t have a significant effect on customer satisfaction,  service quality has a significant effect on customer satisfaction, customer satisfaction doesn’t have a significant effect on customer loyalty, product quality  dosen’t  have a significant  effect on  customer loyalty and service quality has a significant effect on customer loyalty of the two independentvariables dosen’t indicate a mediating  relationship  with  customer  satisfaction as a mediator variable.
PENGARUH PROFITABILITAS, LIKUIDITAS, UKURAN PERUSAHAAN DAN LEVERAGE TERHADAP PERINGKAT OBLIGASI
Authors: Darma Marwia , Sulistiyani Tina
Published: April 2021

This study aims to determine the effect of profitability, liquidity, company size and leverage of the financial sector bond ratings in Indonesia Stock Exchange. The data in this research is secondary data obtained from www.idx.co.id. The total sample of 36 manufacturing sectors the company's bond period in 2017, using purposive sampling method. The analysis technique used is the logistic regression analysis and data processing using Eviews 9. The analysis showed that the positive effect on the profitability of bond ratings. liquidity positively affects bond ratings. Firm size positively affects bond ratings. Leverage negatively affect bond ratings. Companies should pay more attention and be able to increase the value of the company's liquidity so that companies ranked category of investment-grade bonds because investors are more interested in investing in bonds in the company investment-grade category.
Better together? Care Quality Commission pushes for post-pandemic remote regulation
Authors: Ramadan Francesca
Published: April 2021

2021 is set to be a year for renewal and recovery, and it is no exception for the regulator. Francesca Ramadan reports on the Care Quality Commission's proposals for greater remote inspection and assessment activity in the post-pandemic future.