bluuebunny/crossref_metadata_2025 huggingface dataset:
Mālik Bin Nabī (1905-1973): Civilizational Approach to Problems of Muslim World in Context of al-Nahda
Authors: Melikova Leyla F.
Published: June 2023

Article is devoted to research of the views of the Algerian philosopher and Muslim intellectual Mālik Bin Nabī (1905-1973) and reviews his sociological, cultural, historical and philosophical ideas. In his works Mālik Bin Nabī was writing about human society, paying special attention to the reasons for the decline of Muslim civilization and raised the issue of the degree of necessity, ways and forms of perception of its achievements. The author points to the complex approach of the thinker to the problems of the civilizational revival of the Muslim world in the context of the phenomenon of nahda ( al-Nahda ), the main problem of which was and remains the problem of relationship with Western civilization. According to M. Bin Nabī, both in political and social aspects, Nahda is conceptually connected with the Muslims’ search for their own identity and a way out of the crisis generated by long centuries of colonization. In its broad socio-cultural context al-Nahda implies an authentic way for Arabs to meet modernity and constitutes one of the main concepts aimed at achieving a way out of the crisis and a genuine revival of the Muslim world. He sees the ways of solving this problem through the expression of the social values of Islam, arising from the moral and ethical foundations of the Islamic religion, which, in his opinion, affect the restoration of Muslim identity in all realms of existence of the global universe. The thinker proposes a way for the productive revival of the Muslim world based on a harmonious synthesis in line with the merging of the achievements of Western philosophical rationalism and the Islamic religious heritage. In addition, in order to unite the efforts of the Afro-Asian peoples in the face of colonialism, the cultural and economic expansion of the West and the true revival, ultimately, of all the peoples of the East, M. Bin Nabī developed the concept of Afro-Asianism , in which he puts forward the tasks of a globalist scale, pursuing again revival goals. According to the ontological differentiation of M. Bin Nabī, present in the ratio of man, time, space, it has an Islamic basis. This aspect can play an important role in both positive and negative reorganization of the world by man. This situation is directly related to the issue of what meaning people give to the world, as well as the level of their responsibility for that.
Relative Ontology and Method of Scientific Theory of Consciousness
Authors: Kolychev Petr M.
Published: June 2023

Consciousness is defined as operating with the meanings of representations, which are what arises in mind under the influence of a stimulus (primary representations) as well as what arises as a result of their transformation (secondary, combined representations). In a first approximation, a representation is expressed by words. The concept of “representation” is a special case of the concept of “information-certainty”, which is the result of distinction. Any distinction is a distinction by a specific attribute and representation is the value of the attribute. In relative ontology, distinction is an essential condition of being that is formalized quantitatively through the operation of ontological subtraction, which is a quantitative expression of representation in relation to consciousness. The finite set of representations for one attribute can always be sorted in ascending order of this attribute values. In the order constructed, each representation corresponds to an attribute number, the only difference of which from a number in mathematics is that the one is always associated with a specific attribute, and the other is not associated with any attribute. The meaning of a representation expressed by an attribute number has a place in an ordered quantitative series of other representations of the same attribute, which is the basis of distinction. Operating with meanings is operating with attributive numbers-meanings. This method of the meaning describing is called the relative method. All operations with the meanings of representations are performed in a multidimensional cognitive space. Each axis of the cognitive space corresponds to an attribute by which representations differ. On each axis there are attribute numbers corresponding to the meanings of representations for the attribute. This approach is a quantitative method of describing of all experimental processes of consciousness, which allows to build a scientific, i.e. quantitative, theory of consciousness with laws written down in a quantitative way. Based on this, it is possible to construct a quantitative calculation of this theory predictions. Such a prediction allows to make an accurate (unambiguous) experimental verification. Due to the quantitative way of describing the operation of meanings, such a theory of consciousness is easily modeled in information technologies, since the latter are also based on the numerical nature of all their processes. The main difference between the relative method and the vast majority of methods using information technologies for text processing is that the relative method, firstly, is not statistical, and secondly, conveys the meaning of the text fully and most adequately. The relative method is effective in operating not only with text data, but also with any data of a different nature, for example, with video data, audio data.
History, its Origins, and End in Context of Philosophy of Liberation
Authors: Kryshtop Ludmila E. , Basmanov Alexey V.
Published: June 2023

The article concerns history, its origins, goals, and end. The article focuses on two concepts of historical development. One is the concept of the “end of history” by Francis Fukuyama. The article’s authors consider in detail the main provisions of this concept. However, the main emphasis is on the critical reception of this concept within the framework of the philosophy of liberation (represented by Arturo Andrés Roig). Roig’s criticism reveals the Eurocentrism inherent in this concept and shows that it carries the main features inherent in the European worldview and European mentality, which is why it is initially perceived as unsuitable for the Latin American continent. The second concept of historical development analyzed in this article is the earlier concept of the “Axial Age” by K. Jaspers. This concept is often perceived as one of the most striking anti-Eurocentric concepts. At the same time, Jaspers himself is regarded as the founder of the dialogue of cultures and intercultural philosophy and a supporter of civilizational pluralism. The article consistently analyzes three aspects of this concept - the motivation for its creation (presented by Jaspers himself), the criteria for identifying historical and prehistoric cultures (and the associated identification of three centers of the axial period), and the question of the possibility of a new axial age. The article argues that Jaspers’ concept can rightly be called Eurocentric rather than anti-Eurocentric, since both in the initial motivation for creating this concept and in the process of its development and vision of the prospects for the possibility of a new axial age, Jaspers proceeds from the presuppositions characteristic of the European worldview, which is universalized by him and presented as objective and the only correct ones. Ultimately, the study shows that the fight against Eurocentrism is a logical continuation of the latter and carries all the main features of the European mentality.
“Mankurt” — “Xrod” — “Das Man”: Crisis of Modernity in Late Period of Chingiz Aitmatov’s Work
Authors: Kadyrov Argen I.
Published: June 2023

The research is devoted to the historical and philosophical analysis of the work of the Kyrgyz humanist writer of the Soviet period, Chingiz Aitmatov, whose early work is characterised as a fascination with the “Soul of Faust.” (Spirit of Faust) The result of this was the writer's earlier works, where he fervently perceives the ideas of progress, socialism, and enlightenment, in other words, the main ideas of the modern era. Later, under the huge influence of Russian classical literature, as well as active study of traditional Kyrgyz culture, epic “Manas”, he spoke on such fundamental metaphysical topics as people, personality, fate, morality, humanism, etc., thereby trying to get rid of the “Soul of Faust” (Spirit of Faust) with its straightforwardness, its propensity for the infinite settlement of everything. So the writer gradually asserted himself more and more as a traditional humanist. But despite these attempts, the writer still retained some ambivalence: on the one hand, he acted as a staunch critic of modernity, faceless technology and on the other, he perceived the modernization process as an objective development of history that needs to be perceived and comprehended. The results of the writer's later ideas are new concepts such as “Mankurt” and “Ixrod” usually used to describe the consciousness of a person who became possible at the junction of modernity with tradition. To a certain extent, these concepts are identical to the idea of “Das Man” by M. Heidegger.
La igualdad en la Agenda 2030: un reto histórico del Estado
Authors: Herrera-Camargo Lyda Marcela
Published: June 2023

El presente artículo plantea una reflexión sobre los retos del Estado frente al cumplimiento de la agenda 2030 en torno a la búsqueda de igualdad, dadas las contradicciones que se dan en esta desde su origen y hasta el actual escenario capitalista del siglo XXI, abordando para ello cuatro ejes de análisis: los derechos humanos, el desarrollo, las políticas públicas y la participación.

La metodología de análisis implica una revisión documental que aborda antecedentes históricos y su influencia en la actualidad, retoma planteamientos críticos y aportaciones de estudios con énfasis en América Latina que evidencian la diferencia entre lo planteado como objetivos universales y la realidad capitalista que viene desde la modernidad, hace alusión al esfuerzo colombiano por cumplir estas políticas.

El método utilizado consiste en el relacionamiento entre la crítica teórica de cada uno de los conceptos, su relación con la agenda 2030 y el contexto colombiano.

Las conclusiones muestran problemas del sistema capitalista desde su puesta en marcha y los desafíos estructurales vigentes en los territorios y pobladores en América Latina hasta los aspectos que dan real importancia a la humanidad y al medio ambiente los cuales están en inminente peligro.
Catherine Earnshaw e Nelly Dean: gênero e classe social em “O morro dos ventos uivantes” de Emily Brontë
Authors:   , Camargo Mariana de
Published: June 2023

A obra “O Morro dos Ventos Uivantes”, publicada em 1847, pela poetisa e romancista inglesa Emily Brontë é objeto de estudo de diversas áreas do conhecimento, por apresentar temas complexos e personagens bem construídos. O livro traz uma teia de personagens envoltos em temas essencialmente góticos misturados com questões sociais daquele contexto, permitindo, assim, inúmeras interpretações e estudos. O presente projeto tem por objetivo geral entender as personagens Catherine Earnshaw e Nelly Dean, da obra “O Morro dos Ventos Uivantes”, sob as óticas de classe social e gênero; como objetivo específico busca compreender como a classe social e as condições de gênero estão presentes na construção de ambas e influenciam suas relações e também qual ótica prevalece em determinadas situações. Para sua realização, utilizamos materiais dos estudos bakhtinianos de Análise do Discurso por Beth Brait (2006), Análise de Classe Social com base nos estudos de Terry Eagleton (2005), de Literatura Feminina através de ensaios e outros escritos de Virginia Woolf (2019), e análises aprofundadas de pesquisadores dedicados à obra de Brontë. Espera-se, com esta pesquisa, entender como as questões de gênero e classe social estão presentes na construção das duas personagens e como influenciam suas relações e qual ótica prevalece para cada personagem.
Effects of corporate marketing strategy, brand awareness, and perceived quality on brand equity for accounting service
Authors: Thu Pham Thi Bich , Binh Le Thi
Published: June 2023

Brand equity and trust are consistently the most important antecedents to both behavioral and attitudinal forms of customer loyalty (Taylor et al., 2004). Accounting service refers to a service that offers bookkeeping, accounting, and reporting in alignment with both local and international accounting regulations. These services possess unique qualities, necessitating the service providers to establish themselves as reputable entities. It is crucial for them to maintain their brand equity to attract and retain customers. Thus, the study aims to identify and measure the influence of marketing mix, brand awareness, and perceived quality on brand equity for accounting services in Thanh Hoa province, Vietnam. Quantitative data were collected, including 385 businesses using accounting services at all levels across the country. The research results show that all elements of the marketing mix (product quality, price, distribution, and advertising), brand awareness, and perceived quality have a positive impact on brand equity for accounting services in Thanh Hoa province. The study also contributes some policy implications to help accounting service providers enhance their brand equity and then maintain customer satisfaction and customer loyalty.
The protective hand_Dewen_Myrza_2023
Authors: Dewen Myrza
Published: June 2023

The protective hand: A research in progress examining the influence of cultural values on creative editing.
Clinical Characteristics and Risk Factors of Acute Kidney Injury in Patients with Glyphosate Poisoning
Authors: Park Hyung Hun , Choi Kyu Ill , Lee Je Won , Park Jung Min , Park Jinwook , Noh Sang Moon , Cho Jaekyung , Lee Daero , Cho Jae Chul , Park Dong Chan , Kim Yang Hun , Lee Joo Hwan
Published: June 2023

Purpose: Acute kidney injury (AKI) in patients with glyphosate poisoning has a poor prognosis. This study aimed to predict the risk factors for AKI in patients with glyphosate poisoning at the emergency department (ED). Methods: Clinical data on glyphosate poisoning patients at ED who were older than 18 years were collected retrospectively between January 2013 and December 2019. The clinical characteristics and clinical outcomes of the AKI group in patients with glyphosate poisoning were compared with the non-AKI (NAKI) group. Results: Of 63 glyphosate poisoning patients, AKI was observed in 15 (23.8%). The AKI patients group showed the following: old age (p=0.038), low systolic blood pressure (p=0.021), large amount of ingestion (p=0.026), delayed hospital visits (p=0.009), high white blood cells (WBC) (p<0.001), high neutrophil counts (p<0.001), high neutrophil-lymphocyte (LN) ratios (p<0.001), high serum potassium (p=0.005), low arterial blood pH (p=0.015), and low pO2 (p=0.021), low bicarbonate (p=0.009), and high Poisoning Severity Score (PSS) (p<0.001). AKI patients required hemodialysis, ventilator care (p<0.001, p=0.002), and inotropics (p<0.001). They also showed more intensive care unit admission (p<0.001), longer hospitalization (p<0.001), and high mortality (p<0.001). Logistic multivariate regression analysis showed that high WBCs (OR, 1.223) and increased LN ratios (OR, 1.414) were independently associated with the occurrence of AKI. Conclusion: In patients with glyphosate poisoning at ED, high WBCs and increased LN ratios can help predict the occurrence of AKI.
Assessment and Methods of Nutritional Support during Atropinization in Organophosphate and Carbamate Poisoning Cases
Authors: Park Jong-uk , Min Young-gi , Choi Sangcheon , Ko Dong-wan , Park Eun Jung
Published: June 2023

Purpose: Atropine is an antidote used to relieve muscarinic symptoms in patients with organophosphate and carbamate poisoning. Nutritional support via the enteral nutrition (EN) route might be associated with improved clinical outcomes in critically ill patients. This study examined the administration of nutritional support in patients undergoing atropinization, including methods of supply, outcomes, and complications. Methods: A retrospective observational study was conducted in a tertiary care teaching hospital from 2010 to 2018. Forty-five patients, who were administered with atropine and on mechanical ventilation (MV) due to organophosphate or carbamate poisoning, were enrolled. Results: Nutritional support was initiated on the third day of hospitalization. Thirty-three patients (73.3%) were initially supported using parenteral nutrition (PN). During atropinization, 32 patients (71.1%) received nutritional support via EN (9) or PN (23). There was no obvious reason for not starting EN during atropinization (61.1%). Pneumonia was observed in both patient groups on EN and PN (p=0.049). Patients without nutritional support had a shorter MV duration (p=0.034) than patients with nutritional support. The methods of nutritional support during atropinization did not show differences in the number of hospital days (p=0.711), MV duration (p=0.933), duration of ICU stay (p=0.850), or recovery at discharge (p=0.197). Conclusion: Most patients undergoing atropinization were administered PN without obvious reasons to preclude EN. Nutritional support was not correlated with the treatment outcomes or pneumonia. From these results, it might be possible to choose EN in patients undergoing atropinization, but further studies will be necessary.
Severe Case of Hypermagnesemia Caused by Ingesting Magnesium Containing Fertilizer
Authors: Lee Ka-young , Yu Jin-young , Cho Nam-Jun , Park Samel , Lee Eun-young , Gil Hyo-Wook
Published: June 2023

Hypermagnesemia is a rare condition that is usually iatrogenic in patients with elderly or renal failure. Severe hypermagnesemia is uncommon in patients with a normal renal function. Symptoms due to hypermagnesemia can range from mild symptoms, such as nausea, to severe symptoms, such as cardiac and respiratory arrest. This paper describes a case of a 49-year-old woman who ingested a magnesium-containing fertilizer with normal renal function. Cardiac arrest occurred eight hours after poisoning. Electrocardiography changed from a narrow QRS to a wide QRS and then to a complete atrioventricular block. Her hemodynamic state was unstable. Continuous renal replacement therapy was performed to remove magnesium from the blood, with the subsequent resolution of arrhythmia and hemodynamic stabilization. This paper reviews the pathophysiologic effects of magnesium on the cardiovascular system, clinical manifestation, and treatment of hypermagnesemia.
Factors of Determining N-acetylcysteine Administration in Patients with Acute Acetaminophen Poisoning
Authors: Lee Jeong Hwa , Choi Sangchun , Yoon Sang Kyu , Shin Kyu Cheol
Published: June 2023

Purpose: In acute acetaminophen poisoning, the administration of N-acetylcysteine (NAC) can effectively treat the main complications, such as kidney injury and liver failure. In the current situation, measurements of the acetaminophen concentration are not checked in the usual medical facilities. Therefore, this study examined the factors of determining the administration of NAC in addition to the stated amount of intake. Methods: The medical records of patients who visited Ajou University Hospital emergency center with acetaminophen poisoning from January 2015 to December 2019 were reviewed retrospectively. One hundred and seventy-nine patients were initially included. Among these patients, 82 patients were finally selected according to the inclusion criteria in the study. The inclusion criteria were as follows: patients who were 15 years of age or older; those whose ingested dose, ingested time, and body weight were clearly identified; and patients whose acetaminophen sampling time was within 24 hours. Patients were divided into two groups: NAC administered vs. non-NAC administered. The following variables were compared in these two groups: ingested dose, ingested dose per body weight, hospital arrival time after ingestion, suicide attempt history, psychiatric disease history, classification of toxic/non-toxic groups, duration of hospitalization, and laboratory results. Results: Univariate analysis revealed the ingested dose per body weight, hospital arrival time after ingestion, suicide attempt history, and psychiatric disease history to be the determining factors in administering NAC. Logistic regression analysis confirmed that the ingested dose per body weight was the only significant factor leading to an NAC treatment decision. (Odds ratio=1.039, 95% Confidential interval=1.009-1.070, p=0.009) Conclusion: The ingested dose per body weight was the only determining factor for administering NAC in patients with acute acetaminophen poisoning. On the other hand, additional criteria or indicators for the NAC administration decision will be necessary considering the inaccuracy of the ingested dose per body weight and the efficiency of NAC administration.
Systematic review for economic benefit of poison control center
Authors: Han Eunah , Hwang Hyuna , Yu Gina , Ko Dong Ryul , Kong Taeyoung , You Je Sung , Choa Minhong , Chung Sung Phil
Published: June 2023

Purpose: The purpose of this study was to conduct a systematic review to investigate the socio-economic benefits of the poison control center (PCC) and to assess whether telephone counseling at the poison control center affects the frequency of emergency room visits, hospitalization, and length of stay of patients with acute poisoning. Methods: The authors conducted a medical literature search of the PubMed, EMBASE, and Cochrane Library databases. Two reviewers evaluated the abstracts for eligibility, extracted the data, and assessed the study quality using a standardized tool. Key results such as the cost-benefit ratio, hospital stay days, unnecessary emergency room visits or hospitalizations, and reduced hospital charges were extracted from the studies. When meta-analysis was possible, it was performed using RevMan software (RevMan version 5.4). Results: Among 299 non-duplicated studies, 19 were relevant to the study questions. The cost-benefit ratios of PCC showed a wide range from 0.76 to 36 (average 6.8) according to the level of the medical expense of each country and whether the study included intentional poisoning. PCC reduced unnecessary visits to healthcare facilities. PCC consultation shortened the length of hospital stay by 1.82 (95% CI, 1.07-2.57) days. Conclusion: The systematic review and meta-analysis support the hypothesis that the PCC operation is cost-beneficial. However, when implementing the PCC concept in Korea in the future, it is necessary to prepare an institutional framework to ensure a costeffective model.
Delayed death after chlorfenapyr poisoning
Authors: Lee Jang Young
Published: June 2023

Chlorfenapyr is a widely used insecticide, that is very lethal if ingested. It exhibits delayed toxicity in which there are few symptoms at first which suddenly worsen after a few days. A 66-year-old female patient ingested about 90 mL of chlorfenapyr liquid hydrating agent (Chlofenapyr 10%) and showed stable vital signs with no specific symptoms and findings other than a mild fever, vomiting, and nausea. From the 3rd day of ingestion, creatine kinase was high, and rhabdomyolysis was suspected. From the 4th day of ingestion, pancreatic enzymes began to gradually increase. A diffusion-weighted image showed a multifocal high signal intensity in the white matter and corpus callosum area. On the 8th day after ingestion, she suffered a high fever and a heart attack and died. Thus, if a patient is suspected of taking chlorfenapyr, he/she needs active treatment and monitoring even if he/she does not exhibit any symptoms.
Effect on blood heavy metal concentration in gas poisoning by combustion of ignition coal: Pilot study
Authors: Lee Sang Hwan , Lee Juncheol , Cho Yongil , Ko Byuk Sung , Oh Jaehoon , Kang Hyunggoo
Published: June 2023

Purpose: It is known that the most common cause of gas poisoning in Korea is suicide attempts by burning ignition coals. Ignition coals are made from waste wood, and studies have been reported that heavy metals are emitted when this coal is burned. However, there was no study on how much heavy metal poisoning occurs in the human body through this, so this study was planned to find out whether the concentration of heavy metals in the blood increased in patients exposed to ignition coal combustion. Methods: From April 2020 to April 2021, blood lead, mercury, and cadmium concentrations were investigated in carbon monoxide poisoning patients who visited one regional emergency medical center in Seoul, and their association with exposure time, source of poisoning, and rhabdomyolysis were investigated. Results: During the study period, a total of 136 carbon monoxide poisoning patients were tested for heavy metals, and 81 cases of poisoning by ignition coal were reported. When comparing poisoning caused by combustion of ignition coal and other substances, there was no difference in the concentrations of lead, mercury, and cadmium in the blood, and there was no difference in the number of patients above the reference range. However, the patients exposed to more than 5 hours of ignition coal gas exposure are more frequent than those in the group less than 5 hours in lead (51.4% vs. 23.9%, p=0.012). Conclusion: Compared to poisoning with other combustible substances, the blood concentration of lead, mercury, and cadmium does not increase further in patients with gas poisoning by ignition coal. However, prolonged exposure may result in elevated levels of lead.
A case of various clinical aspects associated with cardiotoxicity after glufosinate poisoning
Authors: Kim Seon Tae
Published: June 2023

Glufosinate-containing herbicides is a non-selective herbicide commonly used worldwide. As the use of them increased gradually since paraquat was banned in 2012, the number of suicides by their ingestion is also increasing continuously. Complications of glufosinate-containing herbicide poisoning include various central nervous system (CNS) toxicities such as convulsions, loss of consciousness, memory impairment, and respiratory depression, which may be accompanied by hemodynamic changes such as bradycardia and hypotension. However, it is very rare that arrhythmias other than bradycardia occurred and Takotsubo cardiomyopathy was combined due to cardiotoxicity. A 71-year-old female patient was transferred to our hospital after ingesting 500 mL of glufosinate-containing herbicide and receiving 5 L of gastric lavage at a local hospital. A few hours later, she presented stuporous mentality, respiratory depression, and convulsions, and was accompanied by hypotension and bradycardia. On the second day of admission, electrocardiogram (ECG) showed bradycardia and QTc prolongation with hemodynamic Instability. Accordingly, we conducted the early treatment with continuous renal replacement therapy (CRRT) and the application of temporary cardiac pacemaker. An echocardiogram demonstrated decreased ejection fraction (EF) and Takotsubo cardiomyopathy on the third day of admission. Then, she was discharged safely with conservative treatment. At the follow-up after 1 year, Takotsubo cardiomyopathy, EF and QTc prolongation were recovered on echocardiogram and ECG. Because cardiac toxicity after glufosinate-containing herbicide poisoning may cause life-threatening consequences, caution is required while treating the patient. Therefore, if electrocardiogram changes are seen in the elderly with a large amount of glufosinate herbicide ingestion, additional cardiac function test through echocardiography should be concerned, and early treatment through CRRT or artificial cardiac pacing should be considered.
Inflammatory cytokines in patients with pesticide poisoning: a pilot study
Authors: Kim Hyun Joon , Kim Wook-Joon , Lee Dong Wook , Jung Seung-Hyun , Cho Nam-Jun , Park Samel , Lee Eun Young , Gil Hyo-Wook
Published: June 2023

Purpose: Acute pesticide poisoning is lethal and can lead to death. A few studies about the effects of acute pesticide poisoning have focused on the immune system. In the current study, we preliminarily investigated the changes in blood inflammatory cytokine levels in acute pesticide poisoning patients. Methods: In this study, we prospectively investigated the inflammatory cytokines in patients with acute pesticide poisoning. This study included patients admitted from February 2021 to November 2021 with a diagnosis of intentional poisoning by pesticide ingestion. The inflammatory cytokines measured were IFN-γ, IL-1β, IL-6, and TNF-α. Results: Totally, 27 patients were enrolled in this study. The types of pesticide ingested were glufosinate (n=6), glyphosate (n=8), organophosphate (n=4), pyrethroid (n=2), and others (n=7). The levels of inflammatory cytokines obtained were as follows: IFN-γ 2.78±8.03 pg/ml, IL-1β 2.62±2.03 pg/ml, IL-6 44.58±80.16 pg/ml, and TNF-α 11.80±15.60 pg/ml. The overall mortality rate was 11.1% (3/27), and levels of IL-1β and TNF-α were significantly higher in the death group compared to the survival group. Conclusion: Increased levels of IL-6 and TNF-α were observed in patients with acute pesticide poisoning. IL-1β and TNF-α were significantly higher in the death group as compared to the survival group. Our results indicate the occurrence of an inflammatory response due to the activation of immune cells by pesticide poisoning. Future large-scale studies need to be conducted to investigate the application of inflammatory cytokines as predictors and therapeutic targets.
Characteristics of poisoning patients visiting emergency departments before and after the COVID-19 pandemic
Authors: Seung Jae Kee , Yongil Cho , Hyunggoo Kang , Tae Ho Lim , Jaehoon Oh , Byuk Sung Ko , Juncheol Lee
Published: June 2023

Purpose: This study investigates the characteristics and prognosis of acute poisoning patients visiting nationwide emergency departments before and after the Coronavirus disease 2019 (COVID-19) pandemic. Data were obtained from the National Emergency Department Information System (NEDIS). Methods: This nationwide retrospective observational study included acute poisoning patients who visited the emergency departments between February 1 to December 31, 2020, which has been determined as the pandemic period. The same periods in 2018 and 2019 were designated as the control periods. The primary outcome assessed was the length of stay in emergency departments (EDLOS). The secondary outcomes examined were intensive care unit admission rate and in-hospital mortality rate before and after the pandemic. A subgroup analysis was performed for inpatients and intentional poisoning patients. Results: A total of 163,560 patients were included in the study. During the pandemic, the proportion of women increased from 50.0% in 2018 and 50.3% in 2019 to 52.5% in 2020. Patients aged 20-29 years increased from 13.4% in 2018 and 13.9% in 2019 to 16.6% in 2020. A rise in cases of intentional poisoning was also noted - from 33.9% in 2018 and 34.0% in 2019 to 38.4% in 2020. Evaluating the hospitalized poisoned patients revealed that the EDLOS increased from 3.8 hours in 2018 and 3.7 hours in 2019 to 4.2 hours in 2020. ICU admissions were also markedly increased (2018, 48.2%; 2019, 51.8%; 2020, 53.2%) among hospitalized patients. Conclusion: The COVID-19 pandemic has changed the epidemiology, clinical characteristics, and prognosis of acute poisoning patients visiting nationwide emergency departments in Korea. The proportion of young adults, women, and intentional poisoning patients has increased after the COVID-19 pandemic. Prolonged length of stay at the emergency department and an increased rate of intensive care unit admissions were determined in hospitalized acute poisoning patients.
Bronchiolitis in Pediatric Intensive Care Units in Brazil: a single centre study
Authors: Campos Amanda Lohanny Sousa , Oliveira Nayara Rodrigues Gomes de , Silva Laís Aparecida da , Oliveira Aika Ribeiro Kubo de , Fonseca Jakeline Godinho , Rézio Geovana Sôffa
Published: June 2023

Objective: identify the epidemiological characteristics of children with
bronchiolitis hospitalized in pediatric intensive care units of a public
emergency hospital. Methods: this quantitative cross-sectional study
collected data from electronic medical records using a semi-structured
instrument with items regarding sociodemographic and clinical
characteristics of children with bronchiolitis hospitalized in the
pediatric intensive care unit from April 2018 to April 2020. Results: a
total of 73 children were included. Most children were under six months
old (56.16%) and male (60.27%), and the most frequent causative agent
of bronchiolitis was viral (75.34%). Children under invasive mechanical
ventilation tended to have severe acute respiratory syndrome as a
complication (p = 0.022) and death as an outcome (p = 0.001).
Conclusions: prematurity, male gender, low weight, age below six months,
and congenital heart disease were associated with severe bronchiolitis,
which may progress to acute respiratory failure or severe acute
respiratory syndrome. Mechanical ventilation reduced mortality and
improved the clinical condition of children with bronchiolitis,
especially in severe cases.
Two-dimensional phase-contrast magnetic resonance imaging reveals changes in uterine arterial blood flow in pregnant women treated with tadalafil for fetal growth restriction: A prospective study.
Authors: Nii Masafumi , Enomoto Naosuke , Ishida Masaki , MAGAWA Shoichi , Takakura Sho , Maki Shintaro , Tanaka Kayo , Toriyabe Kuniaki , Tanaka Hiroaki , Kondo Eiji , Sakuma Hajime , Ikeda Tomoaki
Published: June 2023

Objective: To examine the effect of uterine arterial (UtA)
blood flow changes after tadalafil treatment for fetal growth
restriction (FGR) using two-dimensional (2D) phase-contrast magnetic
resonance imaging (PC-MRI). Design: Prospective, controlled
study. Setting: Single tertiary center. Population or
Sample: Fourteen pregnant women with FGR aged 20–44 years and at ≥20
weeks’ gestation were recruited between May 2019 and July 2020.
Methods: They underwent 2D PC-MRI for UtA blood flow
measurement 3 days after diagnosis. They were compared with 14
gestational age (GA)-matched healthy pregnant women (control group). Six
patients in the FGR group received tadalafil at 20 mg twice daily after
the first MRI until delivery. They underwent a second MRI 1 week later
and were compared with 6 of the 14 GA-matched healthy pregnant women.
Main Outcome Measures: Total UtA blood/body surface area
Results: The median total UtA blood/body surface area was 420
mL/min/m (290–494) in the FGR group and 547
mL/min/m (433–681) in the control group (p=0.01).
Percent increases of blood flow in the FGR and control groups were
significantly different at 68.8% (51–75) and 18.8% (16–57),
respectively (p<0.01). Both intraobserver reproducibility
(r=0.997, p<0.01; intraclass correlation coefficients (ICC),
0.997) and interobserver reproducibility (r=0.997, p<0.01;
ICC, 0.998) were high. Conclusions: UtA blood flow in pregnant
women with FGR was significantly lower than that in healthy pregnant
women. Tadalafil may improve UtA blood flow, thereby improving placental
function in pregnant patients with FGR.
Unidirectional trans-Atlantic gene flow and a mixed spawning area shape the genetic connectivity of Atlantic bluefin tuna
Authors: Diaz-Arce Natalia , Gagnaire Pierre-Alexandre , Richardson David , Walter John , Arnaud-Haond Sophie , Fromentin Jean-Marc , Brophy Deirdre , Lutcavage Molly , Addis Piero , Alemany Francisco , Allman Robert , Deguara Simeon , Fraile Igaratza , Goñi Nicolas , Hanke Alex , Karakulak F. Saadet , Pacicco Ashley , Quattro Joseph , Rooker Jay , Arrizabalaga Haritz , Rodriguez-Ezpeleta Naiara
Published: June 2023

The commercially important Atlantic bluefin tuna (Thunnus thynnus), a
large migratory fish, has experienced notable recovery aided by accurate
resource assessment and effective fisheries management efforts.
Traditionally, this species has been perceived as consisting of eastern
and western populations, spawning respectively in the Mediterranean Sea
and the Gulf of Mexico, with mixing occurring throughout the Atlantic.
However, recent studies have emerged challenging this assumption by
revealing weak genetic differentiation and identifying a previously
unknown spawning ground in the Slope Sea used by Atlantic bluefin tuna
of uncertain origin. To further understand the current and past
population structure and connectivity of Atlantic bluefin tuna, we have
assembled a unique dataset including thousands of genome-wide Single
Nucleotide Polymorphisms (SNPs) from five hundred larvae, young of the
year and spawning adult samples covering the three spawning grounds and
including individuals of other Thunnus species. Our analyses support two
weakly differentiated but demographically connected ancestral
populations that interbreed in the Slope Sea. Moreover, we also
identified signatures of introgression from albacore into the Atlantic
bluefin tuna genome, exhibiting varied frequencies across spawning
areas, indicating strong gene flow from the Mediterranean Sea towards
the Slope Sea. We hypothesize that the observed genetic differentiation
may be attributed to increased gene flow caused by a recent
intensification of westward migration by the eastern population, which
could have implications for the genetic diversity and conservation of
western populations. Future conservation efforts should consider these
findings to address potential genetic homogenization in the species.
Biofabrication of 3D cardiac spheroids via magnetic levitation guided assembly for doxorubicin-induced cardiotoxicity study
Authors: Yildiz Ahu Arslan , Onbas Rabia
Published: June 2023

Three-dimensional (3D) cell culture offers alternative approaches to
two-dimensional (2D) cell culture and animal models because it mimics
the physiology and metabolism of native tissues. Magnetic levitation
(MagLev) is a new and promising technique for biofabrication of 3D
cardiac spheroids in a scaffold-free microenvironment. In this study, we
introduce a rapid and cost-effective methodology for the fabrication of
3D cardiac spheroids to investigate doxorubicin-induced cardiotoxicity.
Here, Gadobutrol (Gx) was utilized as a paramagnetic agent to
magnetically assemble cardiac cells. For this purpose, initial cell
density, and culture time were optimized. Then, fabricated 3D cardiac
spheroids were characterized by immunostaining of cellular and
extracellular components. In addition, cardiac-specific markers of
cardiac troponin T and MYH6 were investigated. Further, the drug
response of 3D cardiac spheroids was evaluated for doxorubicin, and IC
values were obtained as 3.5 and 14.7 µM for 2D
control and 3D cardiac spheroids, respectively. The acquired results
emphasize that 3D cardiac spheroids are more resistant to drug exposure.
Hereby, these findings indicate that biofabrication of 3D cardiac
spheroids via MagLev methodology might be an alternative platform for
drug screening.
Association between white matter hyperintensities and altered cerebral blood flow in maintenance hemodialysis patients: a longitudinal study
Authors: Li Mingan , Song Lijun , Yang Wenbo , Chen Qian , Yang Zhenghan , Wang Zhenchang , Xian Junfang , Wang Hao
Published: June 2023

Hemodynamic fluctuations during hemodialysis therapy may result in brain
damage, such as white matter hyperintensity (WMH). Cerebral blood flow
(CBF) changes occurred before the appearance of WMH. To explore changes
in CBF and white matter in hemodialysis patients, patients underwent
twice structural and arterial spin-labeling MRI examinations at an
interval of three years. Based on the changes in CBF between the
baseline and follow-up groups, the hemodialysis patients were divided
into two subgroups, increased CBF group and decreased CBF group. Our
results showed that patients undergoing hemodialysis exhibited increased
cerebral watershed white matter hyperintensities, deep WMH, and
periventricular. Among HC, hemodialysis baseline, and follow-up
patients, the CBF of gray matter, white matter, and whole matter showed
no obvious differences. The CBF of patients with decreased CBF was
higher than that of HC at baseline and lower than that of HC at
follow-up. Compared with the increased CBF group, obvious development of
deep WMH was found in the decreased CBF group for the gray matter, white
matter, and whole matter. Therefore, WMH in hemodialysis patients were
distributed in the deep white matter, periventricular white matter and
cerebral watershed (CW), and progressed with the extension of
hemodialysis duration. CBF in hemodialysis patients could manifest as
both increased and decreased, and WMH in patients with decreased CBF
developed severely with prolongation of hemodialysis duration.
American Marten (Martes americana) and Northern Goshawk (Accipiter gentilis) simultaneously attack Gray Squirrel (Sciurus carolinensis)
Authors: Graves Brent , Petschke Suzanne
Published: June 2023

A Northern Goshawk (Accipiter gentilis) was observed following an American Marten (Martes americana). The marten’s attempts to capture a Gray Squirrel (Sciurus carolinensis) forced the squirrel into the open where the goshawk repeatedly attempted to capture it as the marten chased it through the trees. Attacks on prey flushed by heterospecific predators have been reported for a few other raptors, but this type of interaction has not been reported previously for either goshawks or martens.
Malocclusion in an Arctic Wolf (Canis lupus arctos) from northeast Greenland
Authors: Marquard-Petersen Ulf
Published: June 2023

I document the first case of malocclusion in an Arctic Wolf (Canis lupus arctos) from Greenland. All canine teeth of a wolf found dead on the tundra of northeast Greenland showed evidence of heavy anterior wear resulting from occlusion with the opposite teeth. Additional heavy wear on the incisors indicated a level bite. No cases of malocclusion were found in the largest museum collection of Arctic Wolf skulls (n = 11) from Greenland. However, the collection consisted exclusively of specimens from a northeast Greenland wolf population extirpated ca. 1939; thus, it provided no information on the incidence of malocclusion in more contemporary wolves. A finding of malocclusion in the more recent wolf population could be important because the condition is genetically based and the trait is expressed more frequently with increased inbreeding. The small, geographically isolated wolf population that this wolf was a part of disappeared for reasons unknown after 2002 and genetic conditions cannot be excluded as a contributing factor. Future study of the prevalence and severity of this abnormality in Arctic Wolves from Greenland will be problematic because of the difficulty of acquiring comparative material, but could be conducted on other populations of Arctic Wolves.
Existence and global stability results for Volterra type fractional Hadamard-Stieltjes partial integral equations
Authors: Abbas Saïd , Arara Amaria , Benchohra Mouffak
Published: June 2023

This paper deals with the existence and global stability of solutions of a new class of Volterra partial integral equations of Hadamard-Stieltjes fractional order.
Fixed points of a family of mappings and equivalent characterizations
Authors: Pant Abhijit , Pant R.P. , Joshi M.C. , Rakocevic V.
Published: June 2023

In the present paper we prove a fixed point theorem for a one parameter family of contractive self-mappings, of a complete metric space or a complete b-metric space, each member of which has a unique fixed point that is also the unique common fixed point of the family; the mappings may be continuous or discontinuous at the fixed point. We also prove that under the assumption of a weaker form of continuity the fixed point property for mappings satisfying the contractive conditions employed by us implies completeness of the underlying space. The characterization of completeness obtained by us not only contains Subrahmanyam?s theorem on characterization of completeness as a particular case but also extends it to b-metric spaces. Results on contractive mappings with discontinuity at the fixed point have found applications in neural networks with discontinuous activation function (e.g. Ozgur and Tas [19, 20]).
Some results of fredholm perturbations of multivalued linear operator in normed spaces
Authors: Ammar Aymen , Ezzadam Aicha , Jeribi Aref
Published: June 2023

In the present paper, we establish first the relation between the perturbation of upper Fredholm and strictly singular, and then the relation between lower semi-Fredholm and strictly cosingular linear relations. Most importantly in Theorem 3.4, we show that P(F?(X,Y)) coincides with SC(X,Y).We bring to light, the relationship between the essential spectra of a multivalued linear operator and its selection
A nonexistence result for a class of quasilinear Schrödinger equations with Berestycki-Lions conditions
Authors: He Yubo , Chen Jianhua , Gao Quan
Published: June 2023

In this paper, we study the following quasilinear Schr?dinger equation ??u + V(x)u ? [?(1 + u2)1/2] u/2(1 + u2)1/2 = h(u), x ? RN, where N ? 3, 2+ = 2N/ N?2, V(x) is a potential function. Unlike V ? C2(RN), we only need to assume that V ? C1(RN). By using a change of variable, we prove the non-existence of ground state solutions with Berestycki-Lions conditions, which contain the superliner case: lim s?+? h(s) s = +? and asymptotically linear case: lim s?+? h(s) s = ?. Our results extend and complement the results in related literature.
Global existence and boundedness of solutions in a reaction-diffusion system of Michaelis-Menten-type predator-prey model with nonlinear prey-taxis and random diffusion
Authors: Tian Jiqing
Published: June 2023

This article deals with a 2 ? 2 reaction-diffusion-taxis model consisting of Michaelis-Menten functional response predator-prey system. The critical section of this model is that temporal-spatial evolution of the predators? velocity depends largely on the gradient of prey. But beyond that, this system also inscribes a prey-taxis mechanism that is an immediate movement of the predator u in response to a change of the prey v (which leads to the collection of u). By using contraction mapping principle, Lp estimates and Schauder estimates of parabolic equations, we prove the global existence and uniqueness of classical solutions to this model. In addition to this, we prove the global boundedness of solutions by overcome the difficulties brought by nonlinear prey-taxis.
The exosome-transmitted lncRNA LOC100132249 induces endothelial dysfunction in diabetic retinopathy
Authors: Hu Zizhong , Wang Jingfan , Pan Ting , Li Xinsheng , Tao Chao , Wu Yan , Wang Xingxing , Zhang Zhengyu , Liu Yu , Zhang Weiwei , Xu Changlin , Wu Xinjing , Gu Qinyuan , Fan Yuanyuan , Qian Huiming , Mugisha Aime , Yuan Songtao , Liu Qinghuai , Xie Ping
Published: June 2023

Diabetic retinopathy (DR), one of the most common microangiopathic complications in diabetes mellitus, causes severe visual damage among working-age populations. Retinal vascular endothelial cells, the key cell type in DR pathogenesis, are responsible for abnormal retinal angiogenesis in advanced stages of DR. The roles of exosomes in DR have been largely unknown. In this study, we report the first evidence that exosomes derived from the vitreous humor of patients with proliferative diabetic retinopathy (PDR-exo) promote proliferation, migration and tube formation of human retinal vascular endothelial cells (HRVECs). We identified lncRNA LOC100132249 enrichment in PDR-exo via high-throughput sequencing. This lncRNA, also mainly derived from HRVECs, promoted angiogenesis both in vitro and in vivo. Mechanistically, LOC100132249 acted as a competing endogenous sponge of microRNA-199a-5p (miR-199a-5p), thus regulating the endothelial-mesenchymal transition (EndMT) promoter SNAI1 via activation of the Wnt/β-catenin pathway, and ultimately resulting in endothelial dysfunction. In conclusion, our findings underscored the pathogenic role of endothelial-derived exosomes via the LOC100132249/miR-199a-5p/SNAI1 axis in DR angiogenesis, and may shed light on new therapeutic strategies for future treatment of DR.