bluuebunny/crossref_metadata_2025 huggingface dataset:
Studi Peranan Fasilitas Pokok Terhadap Operasional Pelabuhan Perikanan Nusantara (PPN) Prigi Kabupaten Trenggalek
Authors: Habibulloh Budi Luhur , Moetriono Hary
Published: November 2023

PPN Prigi yang berada di Kabupaten Trenggalek memiliki fasilitas pokok antara lain breakwater, revetment, dermaga, kolam pelabuhan, jetty, alur pelayaran, jalan komplek, dan drainase. Seiring dengan berkembangnya waktu, beberapa bangunan dan infrastruktur dari fasilitas pokok PPN Prigi ada yang mengalami kerusakan sehingga sangat mempengaruhi operasional dari pelabuhan. Selain disebabkan oleh faktor alam, hal ini juga disebabkan karena kurangnya pengawasan dan pengelolaan terhadap fasilitas tersebut. Penelitian ini bertujuan untuk mengetahui tingkat pemanfaatan fasilitas pokok di PPN Prigi dan kesesuaian dengan syarat Peraturan Pemerintah Nomor 27 Tahun 2021. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dan deskriptif kuantitatif. Dari hasil penelitian, didapatkan hasil bahwa fasilitas pokok PPN Prigi sudah sesuai dengan Peraturan Pemerintah Nomor 27 Tahun 2021, namun pemanfaatan dermaga dan kolam pelabuhan belum optimal karena faktor kunjungan, jumlah, dan jarak antar kapal. Breakwater, Jetty, Jalan Komplek, dan Drainase mengalami kerusakan karena faktor alam dan faktor kurangnya pengawasan dan pengelolaan.
ANALYSIS OF ACCELERATION OF STRUCTURE WORK TIME USING CPM METHOD IN THE 57 NGANJUK HOTEL DEVELOPMENT PROJECT
Authors: Maulana Putra Muhammad Andi
Published: November 2023

Structural work is a major job in a project for the construction of high-rise buildings and other buildings, because the structure is a strengthening foundation of a building. In the Nganjuk Guest House 57 Hotel development project, it becomes a place to conduct research. Accelerating the duration of structural work on a schedule in a project is the beginning of an acceleration in other project work, because if structural work can be completed quickly, other work can also be completed earlier too. In this study, the acceleration of the schedule uses the CPM (Critical Path Method) method and with the help of Microsoft Project 2013 software which in this study aims to serve as a reference for contractors to work on the next project. Microsoft Project 2013 functions to make normal scheduling and determine work that is on a critical path, and the CPM method is a method of speeding up the duration of a job in a critical area. The data analysis carried out by the researchers was from the master schedule, RAB, and HSPK in 2022 which were then processed in such a way and with the help of Microsoft Project 2013. In the normal structural work duration data it was written for 246 days with a total overall construction cost of Rp. 15,881,406,908.69 and after acceleration with the CPM (Critical Path Method) method, acceleration is obtained for 81 days by adding 3 hours of overtime each day on critical work with an overtime fee of Rp. 211,214,347.45. Then the duration of the change is obtained to be 165 days with a processing fee of Rp. 16,092,621,256.14
Compact Tunable Resonance Filters with Ultra-Broad Rejection for Silicon Photonics
Authors: Priyadarshini Pratyasha , Goswami Arnab , Velamuri Ashitosh , Das Bijoy Krishna
Published: November 2023

This paper reports a novel design of compact tuneable resonance filter with a highly extinguished and ultra-broad out-of-band rejection in CMOS compatible silicon photonics technology platform. The proposed device is designed with two identically apodized distributed grating structures for guided Fabry-Pérot resonant transmissions in a silicon on insulator rib waveguide structure. The device design parameters are optimized by theoretical simulation for a low insertion loss singly-resonant transmission peak at a desired wavelength.  However, the devices were fabricated (using in-house facilities) to demonstrate multiple resonant transmission peaks along with a singly-resonant one.  We observed that a device length of as low as ∼35 𝜇m exhibits a rejection band as large as ∼60 nm with an extinction of ∼40 dB with respect to the resonant wavelength peak at 𝜆𝑟∼1550 nm (FWHM ∼80 pm, IL∼2 dB). The experimental results have been shown to be closely matching to our theoretical simulation and modelling results. As expected from the theoretical prediction, the trend pertaining to the trade-off between passive insertion loss and Q-value of the resonances has been observed depending on the device parameters. The thermo-optic tuning characteristics of resonant wavelengths have been obtained by integrating microheaters in the cavity. The resonance peak has been tuned at a rate of 96 pm per mW of consumed thermal power. The thermo-optic switching response has been measured to be in the order of ~5 𝜇s. As a potential application, noise associated with an amplified pump wavelength (𝜆𝑃∼1550 nm) has been shown to be suppressed by ∼15 dB (up to the detector noise floor) which can be investigated further for large-scale integrated quantum photonic circuits. The demonstrated device can also be explored further for many other applications such as modulation, add-drop multiplexing, sensing etc. 
Detection of ulcerative colitis lesions from weakly annotated colonoscopy videos using bounding boxes
Authors: Al-Ali Safaa , Chaussard John , Li-Thiao-Té Sébastien , Ogier-Denis Éric , Percy-du-Sert Alice , Treton Xavier , Zaag Hatem
Published: November 2023

Ulcerative colitis is a chronic disease characterized by bleeding and ulcers in the colon. Currently, the gastroenterologist reviews the colonoscopy video to assess the disease severity using an endoscopic score. This task is time-consuming and does not consider the size and the number of lesions. Consequently, automatic detection methods were proposed enabling fine-grained assessment of lesion severity. However, they depend on the quality of the training set, and its specificity to the application context. To suit the local clinical setup, we opted for an internal training dataset containing only rough bounding box annotations around lesions. Color information is the primary indicator used by specialists to recognize the lesions. Thus, we propose to use linear models in suitable color spaces to detect lesions. We introduce an efficient sampling scheme for exploring the set of linear classifiers and removing trivial models i.e. those showing zero false negative or positive ratio. Using bounding boxes leads to ex- aggerated false negative/positive ratios due to mislabeled pixels, especially in the corners, resulting in decreased models’ accuracy. Therefore, we propose to evaluate the model sensitivity on the annotation level instead of the pixel level. Our sampling strategy can eliminate up to 25% of trivial models. Despite the limited annotations’ quality, the detectors achieved good performance (93% specificity/89% sensitivity for bleeding and 57% specificity/83% sensitivity for ulcers). The best models exhibit low variability when tested on a small subset of endoscopic images. However, the inter-patient model performance was variable suggesting that appearance normalization is critical in this context.
Over-the-air Aggregation-based Federated Learning for Technology Recognition in Multi-RAT Networks
Authors: Girmay Merkebu , Seif Mohamed , Maglogiannis Vasilis , Naudts Dries , shahid adnan , Poor H. Vincent , moerman ingrid
Published: November 2023

With the continuous evolution of wireless communication and the explosive growth in data traffic, decentralized spectrum sensing has become essential for the optimal utilization of wireless resources. In this direction, we propose an over-the-air aggregation-based Federated Learning (FL) for a technology recognition model that can identify signals from multiple Radio Access Technologies (RATs), including Wi-Fi, Long Term Evolution (LTE), 5G New Radio (NR), Cellular Vehicle-to-Everything PC5 (C-V2X PC5), and Intelligent Transport Systems G5 (ITS-G5). In the proposed FL-based technology recognition framework, we consider edge network elements as clients to train local models and a central server to create the global model. In each client, a Convolutional Neural Network (CNN)-based model is trained from Inphase and Quadrature (IQ) samples collected from a certain combination of RATs. The possible combination of RATs considered in the clients is selected based on the capabilities of the real-world network elements that can be used as a client.

The FL framework involves a process where multiple clients periodically send updates derived from local data to a central server, which then integrates these contributions to enhance a shared global model. This method ensures that the system stays current with the evolving real-world environment while also minimizing bandwidth required for training data transfer and allowing for the maintenance of personalized local models on each client’s end.
Peran Kepala Sekolah Sebagai Penguatan Kapasitas Guru dalam Meningkatkan Mutu Pendidikan
Authors: Ismunandar Arif
Published: November 2023

The principal as an educational leader in an educational institution must seek initiatives for quality as a form of effort to build an educational system in his school. As the highest leader in the school, the principal has three main functions, namely as an administrator, supervisor, and educational leader. The principal functions as an educational administrator means that to improve the quality of his school, a principal can improve and develop his school facilities such as buildings, equipment or equipment and others that are covered in the field of educational administration. The presentation of this paper is based on the analysis of library data with a descriptive analysis model. From the results of the discussion, it can be concluded that it reveals the importance of a principal in improving teacher performance in schools. To realize a conducive work climate and a comfortable working atmosphere, cooperation from various parties is needed. In general, a principal as a leader is a principal who has special characters or characteristics that include personality, basic skills, experience and professional knowledge, professional training and skills, administrative knowledge and supervision.Keywords: Principal, Teacher, Education Quality
REVENUE COST ANALYSIS DALAM MENGUKUR PROFIT USAHA BUDIDAYA IKAN LELE MUTIARA SISTEM BIOFLOK PT ABAI KOTA MALANG
Authors: Mochammad Fattah  , Agus Tjahjono  , Syafiq Muhammad Ghuffron  , Dwi Sofiati  , Diana Aisyah  , Asyifa Anandya
Published: November 2023

Permintaan ikan lele di Indonesia semakin meningkat untuk memenuhi kebutuhan kuliner dan olahan ikan seperti: sosis, nugget, dan fillet, selain itu produksi ikan lele untuk memenuhi kebutuhan ekspor. Tujuan dari penelitian ini adalah mendeskripsikan teknis usaha budidaya ikan lele mutiara sistem bioflok dan menganalisis profitabilitas usaha budidaya ikan lele Mutiara sistem bioflok. Jenis penelitian yang digunakan adalah deskriptif dengan teknik pengambilan sampel PT ABAI secara purposive dan teknik pengumpulan data secara observasi, wawancara, dan dokumentasi. Analisis data yang dilakukan, antara lain: R/C, Break Even Point, Keuntungan dan Rentabilitas. Budidaya ikan lele Mutiara sistem bioflok menggunakan kolam terpal dengan proses produksi mulai dari persiapan kolam, penebaran benih, pemeliharaan, dan pemanenan yang menghasilkan FCR sebesar 0,7 dengan SR sebesar 88%. Usaha budidaya ikan lele mutiara PT ABAI membutuhkan modal tetap sebesar Rp276.835.000 dan biaya total yang dikeluarkan dalam kegiatan produksi senilai Rp244.232.933. Produksi yang dihasilkan dari kegiatan budidaya dalam satu tahun sebanyak 18.500 Kg dengan padat tebar per siklus 56.000 ekor. Harga jual ikan lele senilai Rp.17.000/Kg sehingga menghasilkan penerimaan dalam 1 tahun senilai Rp314.500.000. Nilai R/C dari kegiatan budidaya ikan lele mutiara sebesar 1,29, keuntungan Rp70.267.067, BEP unit 5.716 ekor, BEP sales sebesar Rp97.173.380 dan rentabilitas 28,77% berdasarkan nilai yang dihasilkan maka usaha dinyatakan menguntungkan.
SYSTEM DYNAMIC ANALYSIS OF RESOURCES MANAGEMENT IN LAYUR FISHERIES IN UJUNG GENTENG, SUKABUMI
Authors: Ahmad Kiffah Kayyisah , Rosalia Ayang Armelita , Lestari Della Ayu
Published: November 2023

Ujung Genteng is one of the areas in Sukabumi which has a large capture fisheries sector. Various capture fishery commodities, especially layur fish which are classified as demersal species, are superior commodities. The layur commodity is caught using hand line and bottom longline by Ujung Genteng fishermen. However, capture fisheries production, especially in 2020 and 2022, has decreased. System dynamic analysis on the management of layur fisheries resources is divided into three sub-model groups: the ecological, social, and economic sub-models. In obtaining results on a dynamic system, accurate data is needed on all stakeholders related to the management of layur fisheries resources, namely the community, fishermen, village government, managers of Fish Auction Places (TPI), and related Fisheries Service data. However, limited data sources in the Ujung Genteng area have made accurate data on the striped fishery only started in 2019. The dynamic analysis results explain in detail the factors causing the decline in catches in the past two years and display the estimated values for each variable that will experience an increase except for Layur catch production.
Cuidados Paliativos em Pacientes com Doenças Terminais: uma abordagem abrangente
Authors: Leite de Sousa Sandyla , Rodrigues Pereira Borges Guilherme , Pinheiro Rossini Gustavo , Marçal Roriz Caio , De Lima Braga Thauanne
Published: November 2023

Os Cuidados Paliativos em Pacientes com Doenças Terminais representam uma abordagem abrangente e essencial no âmbito da assistência à saúde. Diante da complexidade inerente a condições terminais, essa modalidade de cuidado visa proporcionar alívio de sintomas, suporte emocional e melhoria na qualidade de vida dos pacientes, assim como de seus familiares. A abordagem abrangente dos Cuidados Paliativos transcende a mera gestão de sintomas físicos, estendendo-se à atenção às necessidades psicossociais, espirituais e éticas dos indivíduos em fase avançada de doenças. Este enfoque visa promover um cuidado integrado que respeite a dignidade e a autonomia dos pacientes, proporcionando conforto em todas as dimensões de sua experiência, mesmo diante de prognósticos desafiadores.

Ao abordar o tema dos Cuidados Paliativos em Pacientes com Doenças Terminais, este estudo busca contribuir significativamente para o entendimento profundo e abrangente dessa prática clínica. Com uma base metodológica sólida, que incluiu a análise crítica da literatura científica mais relevante e atualizada, o artigo destaca a importância de uma abordagem holística na prestação de cuidados paliativos. O objetivo é não apenas aliviar sintomas, mas também proporcionar suporte emocional e melhorar a qualidade de vida dos pacientes diante das condições terminais. Essa abordagem se baseia em evidências científicas sólidas, assegurando a robustez da revisão e fornecendo subsídios para a prática clínica.

No escopo dos Cuidados Paliativos em Pacientes com Doenças Terminais, ressalta-se a necessidade de uma seleção cuidadosa e personalizada das estratégias de intervenção, considerando a complexidade variável dessas condições. Similar à abordagem cirúrgica na Enfermidade de Crohn mencionada como exemplo, este estudo destaca a importância de escolher a estratégia mais apropriada para cada paciente. A análise profunda das abordagens disponíveis visa proporcionar insights valiosos para profissionais de saúde na tomada de decisões, visando não apenas a eficácia clínica, mas também o respeito à individualidade e dignidade dos pacientes em cuidados paliativos.
Administrative Burdens at the Department of Industry and Trade, Central Java Province, Indonesia
Authors: Lubna Firdausa H  , Puspa W Harumsari , Tiara Aurora Alia S
Published: November 2023

The objective of this article is to elucidate the administrative onus within the Department of Industry and Trade in the Central Java Province. Various perspectives, including expert analyses and interviews with sources, might be employed to elucidate this issue. This research employed methodological strategies such as informant interviews, historical reviews, and evaluations grounded in specific facts. This paper employs a normative legal methodology, utilizing primary data sources such as interviews and secondary data sources such as literature reviews, including legal and non-legal materials. Based on this analysis, it can be deduced that there exists a theory regarding administrative burden, specifically the concept of compliance burden. The government's policies have consequential effects on the community. There are signs of bureaucratic obstacles inside the Industry and Trade Department of the Central Java Province.
Mutual Effect Between Moisture Transfer and Mechanical Response in Infill Masonry Walls of Reinforced Concrete Building Envelope
Authors: Dias José Miranda
Published: November 2023

The external envelope of buildings with reinforced concrete structures (RCS buildings) is subjected to environmental actions, particularly related to wind-driven rain (WDR), external humidity variations, and rising dampness, which can cause significant variations in moisture content to their unreinforced masonry (URM) infill walls, mainly associated to water penetration across that envelope. The consequent moisture transfer across the envelope can change the mechanical response of the URM infill walls and lead to their cracking, which could aggravate the referred water penetration, with a subsequent increase in the risk of building envelope degradation. In reverse, the effects of mechanical loads on moisture transfer across that envelope can be also relevant, in terms of change in the moisture content of these URM infill walls. The aim here is to analyze this type of mutual effect between moisture transfer and mechanical response in URM infill walls of RCS buildings. Essential elements about the characteristics of moisture transfer across URM infill walls and of the interface resistance with moisture flows are summarily described, and the essential evaluation of the mechanical behavior of URM infill walls when subjected to moisture variations is carried out. Moisture transport characteristics are discussed, focusing on analyses of the behavior of masonry elements when subjected to moisture variations. An initial assessment of the mechanical behavior of URM infill walls when subjected to different moisture variations is made through a compression test of a brick masonry specimen with variable moisture content. Following that analysis, an evaluation is made of the moisture transfer in URM infills, as well as the influence of the interface between layers in that moisture transfer and, subsequently, an assessment is made of hygromechanical couplings. Finally, elements for prevention about the causes of degradation of URM infill related to humidity and mechanical actions in the RCS building envelope are discussed.
First Hitting Time and Option Pricing Problem Under Geometric Brownian Motion with Singular Volatility
Authors: Zhang Haoyan , Zhou Yece , Li Xuan , Wu Yinyin
Published: November 2023

In this paper, we discuss the first hitting time and option pricing problem under Geometric Brownian motion with singular volatility. By solving the Sturm-Liouville equation and introducing probability scheme, we derive the closed-form solutions to the target problems. At last, numerical results are provided to analyze our calculations.
MANAGEMENT LEADERSHIP STYLE: A CATALYST TO ORGANIZATIONAL STRENGTH
Authors:   LPT, JD., DBA, Research Director, Universidad De Manila, Philippines, Caday Ma. Aurora T.
Published: November 2023

The study explores the management leadership stylers as a catalyst to organizational strength and perspectives among private and public Higher Education Institutions (HEI). Mixed method is utilized in the study which focuses on quantitative measures to measure the extent of management leadership style as a catalyst to organizational strength and perspectives among the respondents while qualitative is used to evaluate how the management leadership style serves as a catalyst to organizational strength and perspectives among the respondents. Likewise, convenience sampling is utilized in the selection of the sample size. The study comprised One Hundred Twenty Five (125) respondents only. Results show that leadership is concerned on the well-being of the members of team in the organization, consider as high standard and expect members of the team to do the same, show that everyone believes they can work for the best in the team and involves in the decision making, show that leader is best in bringing people, and show that leaders have the capacity to take responsibility and a role leaders when needed that can be counted to adopt to new environment and flexibility.
RETAINING LOCAL INVENTORS AND SCIENTISTS FOR ECONOMIC DEVELOPMENT THROUGH POLICY AMENDMENTS
Authors:   Provincial Director, Department of Science and Technology, Region Xii, Philippines, Mayo PhD Michael Ty , Mallillin PhD Leovigildo Lito D. ,   Professor, Faculty of Arts and Languages, Philippine Normal University, Manila, Philippines
Published: November 2023

The study investigates the retention of local inventors and scientist for economic development through policy amendments. It aims to investigate how may the profile of the respondents be described in terms of gender, age, highest educational attainment, and, years of experiences in his/her field. Likewise, to measure existing policies to the retention of local inventors and scientists in the Philippines demonstrating “as Planned” and “as Implemented” among the respondents, to what extent do these policies affect the decision of local inventors and scientists to stay or leave the country, and to what extent does the demographic profile moderate the retention of scientist and inventors in the Philippines. This study utilizes the descriptive quantitative research design which aims to describe the systematically and accurately phenomenon and situation of the study. Purposive sampling is utilized in gathering the sample size. It is straightforward and simple in its complexity. The study comprised One Hundred Fifty (150) only. Results show that most of the profiles of respondents are female with the age bracket of 46-66 years of age where they have obtained a graduate studies with 11-15 years of experienced as inventors and scientists in their own fields which shows that they are knowledgeable on the RA 7459 and RA 11035 among them as basis for economic development policy amendment, show that the existing policies to the retention and local inventors and scientists are initially planned by the respondents which is being supported by the government. Likewise, the implemented policies of RA 7459 shows that they are being supported by the government as mandated in the existing policy for the retention of local inventors and scientists in the Philippines, show that the extent of the policies for the decision the local inventors and scientist to stay or leave in the country is being initiated in the objectives of RA 7459 which are conducive for the respondents to stay in the country because the policy is being supported from the government significantly that influences their decision to continue their work as an inventor/scientist in the Philippines, and show that the extent of the demographic profile moderate in retention of scientists and inventors in the Philippines under the incentives of RA 7459 that motivates them to continue their work as a scientist/inventor in the Philippines since they are satisfied with the overall support from the government for scientists and inventors influence their decision to stay or leave the country.
Konsep Sombong dalam Al-Qur’an
Authors: Islamiati Dian , Hamnah  , Sunantri Sri
Published: November 2023

This research uses a type of literature research (Library Reseach) with qualitative methods. The sources in this study consist of two types, namely primary and secondary data sources. The primary data source is Tafsir Jalalain which amounts to 2 volumes, while secondary data consists of books or journals related to the theme, such as Minhâjul Qâshidin, Tazkiyatun Nafs, about the dangers of Takabur, thematic studies on Takabur in the perspective of the Qur'an and so on. In addition, data collection techniques in this study use library data sources with content analysis. As for data analysis techniques, researchers use a form of description analysis which is a form of research effort in telling problem solving based on data presentation, analysis and interpertation. The result of this study is the existence of a form of difference in terms of the definition of the meaning of arrogant contained in surah Luqman verse 18. The word consists of Marahân, mukhtal and fakhur. Marahân is an arrogant person with haughty feelings inside.  Mukhtâl is an attitude of pretending to be arrogant when walking in front of others. As for fakhûr is defined as a person who is arrogant by boasting himself excessively. Based on the analysis of the interpretation of surah Luqman Verse 18 in  Tafsir Jalalain, it can be concluded that one who pretends to be arrogant in walking with his face away, then the act is called  Mukhtâl While one who walks on earth haughtily and feels arrogant, then the act is called fakhûr.
Validación de un instrumento para tamizaje de ca prostático en individuos mayores de 40 años
Authors: Ruiz-Pérez Alfonso Antonio , Casaubon-Vargas Mariana
Published: November 2023

ANTECEDENTES: El cáncer de próstata, es un crecimiento descontrolado de células epiteliales de la próstata. Las acciones de detección inician a partir de los 40 años e incluyen: examen médico completo y determinación de Antígeno Prostático Específico.  OBJETIVO: Elaborar y validar un instrumento para tamizaje de Cáncer de Próstata. MATERIAL Y MÉTODOS: Se realizó un estudio observacional, analítico, prospectivo, para construir, validar y aplicar un instrumento de tamizaje para Cáncer de Próstata, el cual se comparó con resultado de APE en sangre como Gold standard. RESULTADOS: El instrumento obtuvo un valor alfa de Cronbach de 0.949 en la prueba piloto y de 0.915 en la aplicación final. Se identificó una frecuencia de 0.5% en alta sospecha de riesgo de ca de próstata y un 1.4% en sospecha moderada, el 89.1% riesgo bajo y un 8.9% sin riesgo. La sensibilidad y especificidad del instrumento con respecto al APE fue de un 38% y 100% respectivamente, y con respecto al diagnóstico definitivo fueron 100% y 98%. CONCLUSIONES: El instrumento de riesgo para detección de ca de próstata es un buen candidato para ser incluido en el tamizaje clínico en poblaciones que no tienen la posibilidad de evaluar constantemente marcadores bioquímicos.
Interleukin-1β gene rs1143634 polymorphism and cardiovascular complications in patients with coronary artery atherosclerosis
Authors: Khazova E. V. , Bulashova O. V. , Valeeva E. V.
Published: November 2023

The course of heart failure, regardless of its etiology, is associated with local and systemic activation of inflammatory signaling cascades. Identification of the association of candidate cytokine genes with the risk of developing coronary heart disease and chronic heart failure remains a subject of interest for many researchers. The review presents an analysis of studies of the rs1143634 polymorphism of the IL-β gene in relation to the risk of atherosclerotic cardiovascular complications. The presence of the minor allele T is associated with an increase in the concentration of IL-1β in the blood serum. Data on the role of the rs1143634 polymorphism of the IL-β gene in atherosclerotic coronary heart disease, including in combination with chronic heart failure syndrome, are presented, taking into account ethnic characteristics and gender of patients. The carriage of the T allele was associated with the risk of developing atherosclerosis and myocardial infarction. At the same time, it is reported that the C allele and the CC genotype of the rs1143634 polymorphism of the IL-1β gene were a genetic risk factor for the development and progression of heart failure. In a number of studies and meta-analyses, the association of this polymorphism with diseases of the cardiovascular system was not confirmed, but certain trajectories of the risk of complications were identified due to differences in the rs1143634 polymorphism of the IL-β gene in heart failure.
Epigenetic drugs: a new frontier in the treatment of heart failure
Authors: Aitbaev K. A. , Murkamilov I. T. , Murkamilova Zh. A. , Fomin V. V. , Kudaibergenova I. O. , Yusupova T. F. , Yusupov F. A.
Published: November 2023

Uncovering the secrets of genome flexibility not only contributed to the development of research in this area, but also served as an impetus for the development of new treatments for human diseases. A better understanding of the biology of chromatin (DNA/histone complexes) and non-coding RNAs (ncRNAs) has enabled the development of epigenetic (epi) preparations capable of modulating transcriptional programs associated with cardiovascular disease. This is especially true in heart failure, where epigenetic mechanisms have been shown to underlie the development of several pathological processes such as left ventricular hypertrophy, fibrosis, cardiomyocyte apoptosis, and microvascular dysfunction. Targeting epigenetic signals may represent a promising approach, especially in patients with heart failure with preserved ejection fraction (HFpEF), where the prognosis remains poor and effective treatments are not yet available. Under these conditions, epigenetics can be used to develop individualized therapeutic approaches, paving the way for personalized medicine. Although the beneficial effects of epi-drugs are gaining more attention, the number of epigenetic compounds used in clinical practice remains low, suggesting the need to develop more selective epi-drugs. In this review, we present a list of new promising epi-drugs for the treatment of cardiovascular diseases, with a focus mainly on HFpEF. The therapeutic effect of these drugs is due to the impact on at least one of the three main epigenetic mechanisms: DNA methylation, histone modification, and non-coding RNA.
READING THE PAST: ANALYSIS OF THE IMPACT OF PREVALENT PANDEMICS ON CITIES
Authors: Farina Stefania , Mileto Camilla , Vegas Fernando
Published: November 2023

Throughout history, dozens of epidemics have appeared cyclically, often causing devastating effects. Some of them, such as plague, cholera, and tuberculosis, have led to significant social, economic, and political consequences, with evident repercussions on cities and architecture. In this regard, urban planning has played an essential role in improving life expectancy and limiting the spread of epidemics. This work aims to study the influence of prevalent pandemics on architecture and urbanism over the centuries to comprehend their response and adaption to new health and social requirements. Through a process of investigation and in-depth examination of the literature review, it has been possible to understand the impact of pandemics in cities. The appearance of the first preventive measures during the plague period, the urban interventions to combat the cholera outbreak, and the neat architectural features adopted following the appearance of tuberculosis are witnesses to this process. Professionals and academics are reflecting on the challenges of the Covid-19 pandemic, which will affect the practice of architecture and urban design. Thanks to the results obtained, it will be possible to reflect on the impact of the pandemic on contemporary cities, understand their potential resilience and hypothesise future strategies.
A Wolf 359 in Sheep's Clothing: Hunting for Substellar Companions in the Fifth-closest System Using Combined High-contrast Imaging and Radial Velocity Analysis
Authors: Bowens-Rubin Rachel , Akana Murphy Joseph M. , Hinz Philip M. , Limbach Mary Anne , Seifahrt Andreas , Kiman Rocio , Salama Maïssa , Mukherjee Sagnick , Brady Madison , Carter Aarynn L. , Jensen-Clem Rebecca , van Kooten Maaike A. M. , Isaacson Howard , Kosiarek Molly , Bean Jacob L. , Kasper David , Luque Rafael , Stefánsson Gudmundur , Stürmer Julian
Published: November 2023

Wolf 359 (CN Leo, GJ 406, Gaia DR3 3864972938605115520) is a low-mass star in the fifth-closest neighboring system (2.41 pc). Because of its relative youth and proximity, Wolf 359 offers a unique opportunity to study substellar companions around M stars using infrared high-contrast imaging and radial velocity monitoring. We present the results of Ms-band (4.67 μm) vector vortex coronagraphic imaging using Keck-NIRC2 and add 12 Keck-HIRES and 68 MAROON-X velocities to the radial velocity baseline. Our analysis incorporates these data alongside literature radial velocities from CARMENES, the High Accuracy Radial velocity Planet Searcher, and Keck-HIRES to rule out the existence of a close (a < 10 au) stellar or brown dwarf companion and the majority of large gas giant companions. Our survey does not refute or confirm the long-period radial velocity candidate, Wolf 359 b (P ∼ 2900 days), but rules out the candidate's existence as a large gas giant (>4 M
Jup) assuming an age of younger than 1 Gyr. We discuss the performance of our high-contrast imaging survey to aid future observers using Keck-NIRC2 in conjunction with the vortex coronagraph in the Ms band and conclude by exploring the direct imaging capabilities with JWST to observe Jupiter- and Neptune-mass planets around Wolf 359.
Rapid Dust Growth during Hydrodynamic Clumping due to Streaming Instability
Authors: Tominaga Ryosuke T. , Tanaka Hidekazu
Published: November 2023

Streaming instability is considered to be one of the dominant processes in promoting planetesimal formation by the gravitational collapse of dust clumps. The development of streaming instability is expected to form dust clumps in which the local dust density is strongly enhanced and even greater than the Roche density. The resulting clumps can collapse to form planetesimals. Recent simulations showed that such strong clumping occurs in a wider parameter space than previously expected. However, the indicated timescale for strong clumping can be on the order of tens to hundreds of Keplerian periods. In this paper, we estimate the growth time of dust grains during the pre-clumping phase. We find that the dust growth proceeds considerably before the strong clumping because even the moderate clumping due to streaming instability increases the local dust-to-gas ratio to ≳10. Depending on the sound speed, the dust collision velocity can be kept below ∼1 m s−1 once sufficiently strong dust clumping occurs. Thus, even silicate grains might have the potential to grow safely toward the size whose Stokes number is unity during the clumping. Our results demonstrate the importance of local dust coagulation during dust clumping due to streaming instability.
Cannonball or Bowling Ball: Proper Motion and Parallax for PSR J0002+6216
Authors: Bruzewski S. , Schinzel F. K. , Taylor G. B. , Demorest P. , Frail D. A. , Kerr M. , Kumar P.
Published: November 2023

We report the results of careful astrometric measurements of the cannonball pulsar J0002+6216 carried out over 3 yr using the High Sensitivity Array. We significantly refine the proper motion to μ = 35.3 ± 0.6 mas yr−1 and place new constraints on the distance, with the overall effect of lowering the velocity and increasing the inferred age to 47.60 ± 0.80 kyr. Although the pulsar is brought more in line with the standard natal kick distribution, this new velocity has implications for the morphology of the pulsar wind nebula that surrounds it, the density of the interstellar medium through which it travels, and the age of the supernova remnant (CTB 1) from which it originates.
The devil is in the details: exploring how functionally distinct round goby is among native fish in the Baltic Sea
Authors: Vivó-Pons Antoni , Wallin-Kihlberg Isa , Olsson Jens , Ljungberg Peter , Behrens Jane , Lindegren Martin
Published: November 2023

Understanding the characteristics and conditions that make non-indigenous species (NIS) successful at establishing in recipient communities is a key in determining their potential impacts on native species, as well as to improve management actions such as prevention of future invasions. The round goby (Neogobius melanostomus) is one of the most widespread non-indigenous fish species in the Northern Hemisphere, including the coastal zones of the Baltic Sea. The impacts of round goby in the Baltic Sea are pronounced and multifaceted, yet our knowledge regarding the underlying assembly processes determining its establishment is limited. To overcome this knowledge gap, we applied a trait-based approach to assess the degree of niche overlap and functional (trait) similarity between round goby and native fish species in coastal areas from the Baltic Sea, based on the functional distinctiveness metric. Our results show that round goby is generally quite similar (or not dissimilar) to the native fish of the regional species pool, at least in terms of its overall trait composition. Conversely, round goby demonstrates pronounced differences compared to the native community in its display of parental care and territorial behaviour. Such differences in individual traits could play an important role in round goby’s invasion success in the Baltic Sea, including its interactions with native species (e.g. competition). Our results and their potential implications may be highly relevant for conservation and management if integrated within existing risk assessment tools for biological invasions in order to prioritise and enhance the effectiveness of preventative actions towards the expansion of round goby.
Une interview inédite de John Bowlby, par le pédiatre américain Milton Senn, à Londres en 1977
Authors: Guédeney Antoine
Published: November 2023

Interview publiée seulement en ligne, de John Bowlby par Milton Senn, ancien directeur du Child Study Center de Yale. L’interview a eu lieu à Londres le 19 octobre 1977. Ceci est la seule interview, à notre connaissance, qui ait été donnée par John Bowlby et qui soit librement disponible et dans laquelle Bowlby parle de façon très libre de ses influences, de sa trajectoire et de ses collaborations.
Entreprises, risques et transition écologique
Authors: Rondeau du Noyer Lucie
Published: November 2023

La conscience accrue des risques environnementaux contribue à réactualiser un débat constitutif du socialisme : est-ce à l’échelle de la société ou de l’entreprise que doit s’amorcer la transition vers une économie et une société plus justes ?
Santé, travail et mouvement socialiste
Authors: Fontaine Marion
Published: November 2023

Les questions de santé et de risque au travail ont fait l’objet d’un intérêt précoce de la part d’une partie du mouvement socialiste et ouvrier. La politisation de ces questions s’est cependant durablement heurtée au dilemme entre le niveau de vie, le salaire d’une part, la santé, l’espérance d’une vie de l’autre. Elle est rarement parvenue par ailleurs à faire prévaloir une logique de prévention, plus que de simple réparation financière des préjudices. Sur la base de ce bilan, l’article s’interroge donc sur la manière dont pourrait se construire, aujourd’hui, une politique effective et durable des enjeux de santé au travail.
Une difficile proximité. Obscurité, vision et désir chez Dante et le pseudo-Denys
Authors: Piro Vincenzo
Published: November 2023

L’essai de rapprocher le monde de Dante dans sa complexité de la spiritualité et des constructions théologiques de Denys l’Aréopagite n’a pas encore produit un résultat unanime. Malgré une proximité de thèmes, la richesse des formes du monde dantesque, sa sensibilité aux événements historiques et la figure de Béatrice semblent, au moins en partie, résister à l’intensité silencieuse de la théologie dionysienne. L’article met en évidence le caractère décisif de la question de l’obscurité dans la tentative d’établir un rapport entre la perspective dantesque et celle de Denys. À partir de la sémantisation variée du rapport entre la lumière et les ténèbres à l’œuvre chez Dante, on cherche à établir la persistance d’une inspiration dionysienne – avec une attention particulière à l’articulation entre la vision de Dieu, l’obscurité et le mouvement du désir –, telle qu’elle émerge du Chant XXXIII du Paradis .
Dehors-dedans. Structure d’un débat sur l’âme dans le Phèdre
Authors: Vasiliu Anca
Published: November 2023

Un renversement topique et plusieurs retournements et contrepoints mythologiques définissent la structure du Phèdre . Régenté par Socrate, ce rythme syncopé de secousse et d’apaisement, propre à une initiation, traverse tout le dialogue. En cartographiant les redressements mythologiques et rhétoriques, les rétractations signifiées par le mouvement palinodique, les retournements de fond (vie/mort, virginité/fécondité) et les traversées de limites indiquées par des détails topographiques et des rituels, on arrive à saisir le tableau dynamique de l’âme que Platon ne définit pas mais met en œuvre en y intégrant son lecteur.
Le sens de la route
Authors: Fabre Clément
Published: November 2023

Comment les discours médicaux sur la différence des corps interviennent-ils dans le fonctionnement des ordres coloniaux ? La concession internationale de Shanghai, au cœur du semi-colonialisme et des réseaux médicaux occidentaux dans la Chine du xix e - xx e  siècle, offre un riche observatoire pour explorer cette question. Un corpus exceptionnel sur la gestion municipale des accidents de la circulation entre 1911 et 1918 permet ici d’y traquer les conséquences pratiques des théories raciales par lesquelles certains médecins expliquent alors ces mêmes accidents.
Du Pont-Euxin à la Thrace occidentale, la gouvernance des réfugiés grecs durant la transition politique de Constantinople (mars-août 1923)
Authors: Moraïtis Stélios
Published: November 2023

Expulsées du Pont-Euxin par l’armée turque, les populations grecques orthodoxes parvenues à Constantinople en 1923 sont enfermées dans des camps où se développent des épidémies. Par une approche socio-historique de l’action publique, cet article rend compte, dans le contexte de transition politique, de la manière dont la situation des réfugiés grecs, construite en problème public, rend possible la configuration d’un mode de gouvernance basé sur la coopération d’acteurs hétérogènes dont les intérêts convergent.
Convex radial solutions for Monge-Amp$ \grave{\text e} $re equations involving the gradient
Authors: Yang Zhilin
Published: November 2023

This paper deals with the existence and multiplicity of convex radial solutions for the Monge-Amp$ \grave{\text e} $re equation involving the gradient $ \nabla u $:

   \begin{document}$ \begin{cases} \det (D^2u) = f(|x|, -u, |\nabla u|), x\in B, \\ u|_{\partial B} = 0, \end{cases} $\end{document}

where $ B: = \{x\in \mathbb R^N: |x| < 1\} $. The fixed point index theory is employed in the proofs of the main results.
Adaptive advantage of Sesbania virgata (Cav.) Pers. in the phytochemical production: the influence on fungi occurring in seeds
Authors: Id Vera Lygia El Id , Santos Junior Nelson Augusto dos
Published: November 2023

Sesbania virgata is a native Brazilian plant species. It exhibits rapid growth, a high soil cover potential, and efficient soil seed bank formation and is used in environmental restoration projects. The soil seed bank is susceptible to fungal infection and other biotic factors. However, only a few studies have reported on the fungi on the surface of S. virgata seeds. Moreover, little is known about how substances present in the seed integument affect fungal communities and their role in adapting to and thriving in new environments. Herein, S. virgata seeds were collected from populations that produce or do not produce the flavonoid catechin in the seed coat. These seeds were subjected to laboratory tests to identify and quantify the fungal populations in the integument. We selected and subjected three genera to irrigation and inoculation tests with S. virgata extracts and seeds from both populations. We observed that the aqueous seed coat extracts inhibited Alternaria sp. micellar and augmented Phoma sp. growth. Phoma sp. also caused post-germinated seed lethality. Our data indicate that the seed coat of S. virgata contains antifungal substances that endow this species with an adaptive advantage.
The centrality of Medea in Gower’s ‘Tale of Jason and Medea’
Authors: Zuraikat Malek Jamal
Published: November 2023

Showcasing some examples of Gower’s artistic use of form to serve content, this article argues that the formalistic structure of ‘The Tale of Jason and Medea’ is a rhetorical means deployed by the poet to manage his narrative content and highlight its center. The article introduces Medea as the center of the tale under discussion providing a textual reading of the formalistic structure of the lines that are said by or about Medea. Acknowledging the tale’s iambic tetrameter structure and its role in orchestrating the narrative, the article explains how Medea’s narrative centrality gets defined syllabically and accentually. The article concludes that the formalistic structure of ‘The Tale of Jason and Medea’ is not a poetic decoration or part of traditional poetic templates used by Gower unconsciously, but a rhetorical device deployed by the poet to manage the focus of the narrative.
Cidades mortas: aspectos da memória no texto prefacial
Authors: Morais Caroline de , Ramos Flávia Brocchetto
Published: November 2023

Este estudo articula o texto literário e a memória por meio da análise do paratexto prefacial da obra Cidades mortas, de Monteiro Lobato. Nesse sentido, o corpus de pesquisa está centrado no prefácio ‘Farpas luminosas’, assinado por Marcia Camargos e Vladimir Sacchetta. Com base nesse texto de abertura, tem-se como objetivo examinar o prefácio da obra Cidades mortas, associando o paratexto com a perspectiva de memória, ao reconhecê-lo como possibilidade de significação de memória coletiva do país na decadência da cultura cafeeira vivida pelo autor e retratada nos contos da antologia. A metodologia segue a abordagem qualitativa e a pesquisa bibliográfica, e o material literário é examinado com embasamento teórico de Genette, Le Goff e Halbwachs. Como resultados, salienta-se que o texto literário pode ser considerado uma ferramenta de aproximação entre o leitor e os conhecimentos permeados em sua memória.