bluuebunny/crossref_metadata_2025 huggingface dataset:
Parents' experiences of parenting a child with profound intellectual and multiple disabilities in France: A qualitative study
Authors: Aim Marie‐Anastasie , Rousseau Marie‐Christine , Hamouda Ilyes , Anzola Any Beltran , de Villemeur Thierry Billette , Milh Mathieu , Maincent Kim , Lind Katia , Auquier Pascal , Baumstarck Karine , Dany Lionel
Published: November 2023

Introduction

Parents of persons with profound intellectual and multiple disabilities (PIMD) play a major and often lifelong role in the care and support of their child. A better understanding of parents' perspectives regarding their experiences of parenting their child with PIMD is essential to support them more effectively. Although this topic has been explored extensively in Anglo‐Saxon and Northern European countries, little is known about the experience of these parents in a highly institutionalized context such as that in France.

Objective

We explored parents' experiences of the activities they performed to care for their child with PIMD (namely, the ‘parenting work’) in the French context.

Method

Qualitative semistructured interviews were conducted by telephone with 34 parents of persons with PIMD aged 8–35. The resulting data were analyzed using thematic analysis.

Results

The analysis highlighted the diversity of activities performed by parents as well as the influence of context on the forms of this parenting work. Five themes were developed: (1) navigating the challenges of obtaining medical recognition; (2) negotiating a concealed domain and becoming an expert; (3) unfolding medical and medicosocial care management; (4) navigating the challenges of daily living and (5) shaping one's child's possibilities.

Conclusion

This study offers a better understanding of the challenges, levers and expectations of parents of children with PIMD in France. Contextual factors such as the lack of knowledge of PIMD among health professionals, access to knowledge and know‐how associated with care management, the administrative complexity of access to care and equipment, institutional issues (e.g., professional turnover) and societal ableism (e.g., access to infrastructures, interpersonal discrimination) shape the work parents perform to support their child's needs. It is necessary to consider contextual aspects to better support these parents and their children. Suggestions for applications are provided in the discussion.

Patient or Public Contribution

One of the researchers, a parent of a child with PIMD, supported the research design and provided feedback on the study's procedures and manuscript.
Persistence as a multidimensional construct: A new insight into the multidimensional persistence scale
Authors: Pajestka Grzegorz , Poraj‐Weder Magdalena
Published: November 2023

Persistence, defined as a trait‐like characteristic, reflects the personal tendency to endure different hardships. In a recently developed model, three dimensions—persistence despite difficulties, persistence despite fear, and inappropriate persistence—were proposed to cover distinct facets of this ability, along with goal‐time preferences as a persistence‐related construct. The Multidimensional Persistence Scale (MPS) and the Goal‐Time Preferences Scale (GTPS) were created to gauge these two separate constructs. In the current study, we conducted two studies using the Polish version of the scales (MPS‐PL and GTPS‐PL, respectively), with the aim of evaluating both measures. We also proposed a profile model as better reflecting the multidimensionality of persistence as opposed to the original superordinate model. In Study 1, the three‐factor structure of the MPS‐PL was supported by a confirmatory factor analysis. In contrast, the GTPS‐PL showed a poor fit to the data as well as a vague factor structure. In Study 2, we tested the nomological network of the MPS‐PL, providing evidence for its construct validity as well as the distinctiveness of its dimensions. Finally, we conducted a latent profile analysis, which revealed the three qualitatively different configurations of persistence dimensions in the total study sample. Overall, the evidence we gathered supports our proposal about persistence as a multidimensional profile construct.
Molecular dynamics simulations of magnesium aluminosilicate glass structure: High‐coordinated alumina and oxygen tricluster formation
Authors: Welch Rebecca S. , Salrin Tyler C. , Greiner Tyler , Bragatto Caio Barca , Mauro John C.
Published: November 2023

Previous research has shown a consistent discrepancy in the reported structure of alkaline earth aluminosilicate glasses using molecular dynamics (MD) simulations versus nuclear magnetic resonance (NMR) experiments. Past MD results have consistently shown less than 5% five‐coordinated Al units (Al[5]) in peraluminous glass compositions, but with high fractions of triple‐bonded oxygens (TBO, i.e., triclusters). Experimental results have shown a high fraction of Al[5] with no direct evidence for TBO. One of the main criticisms associated with high TBO content found in MD‐generated glass structures is the use of classical interatomic potentials. To investigate this issue, we analyze the formation of both TBO and Al[5] using three independently developed potentials with varying silica content and [Al2O3]/[MgO] ratios for the magnesium aluminosilicate (MAS) system. We specifically choose compositions with high ratios of alumina to magnesium oxide as this region is not as commonly explored. Results indicate that Al[5] charge compensates the Al network in metaluminous compositions (compositions with more Mg than Al) while both TBO and Al[5] are prevalent in peraluminous ranges (high Al content compositions) to charge balance Al units. From the literature, NMR experiments report MAS glasses with varying Al[5] fractions and show significant differences for the same reported compositions. When comparing MD results from this work, the fraction of calculated Al[5] is within the experimental variation found in the literature. This indicates that classical potentials can accurately capture alumina environments and that both Al[5] and TBO can coexist in relatively high fractions. From the consistency in our results, we conclude that TBOs are inherent to the aluminosilicate glass system and are not simulation artifacts.
CEO–board connections and the cost of equity capital: International evidence
Authors: Bhuyan Md Nazmul Hasan , Javakhadze David
Published: November 2023

In this article, we investigate the effect of chief executive officer (CEO)–board connections on the cost of equity capital in an international setting. We find that CEO–board connections have a significant negative effect on the cost of equity. Our results are robust to alternative variable measurements, model specifications, and potential endogeneity adjustments. Examining the channel, we show that social ties reduce information asymmetry issues. We further show that firm‐level operational complexities and investment intensity, as well as country‐level developmental attributes and culture, moderate the association between CEO–board connections and the cost of equity capital.
Baclofen and the risk of fall and fracture in older adults: A real‐world cohort study
Authors: Hwang Y. Joseph , Chang Alex R. , Brotman Daniel J. , Inker Lesley A. , Grams Morgan E. , Shin Jung‐Im
Published: November 2023

Background

The growth of oral muscle relaxant prescriptions among older adults in the United States is concerning due to the drugs' adverse sedative effects. Baclofen is a gamma‐aminobutyric acid agonist muscle relaxant that is associated with encephalopathy. We characterized the risk of fall and fracture associated with oral baclofen against other muscle relaxants (tizanidine or cyclobenzaprine) in older adults.

Methods

We designed a new‐user, active‐comparator study using tertiary health system data from Geisinger Health, Pennsylvania (January 2005 through December 2018). Older adults (aged ≥65 years) newly treated with baclofen, tizanidine, or cyclobenzaprine were included. Propensity score‐based inverse probability of treatment weighting (IPTW) was used to balance the treatment groups on 58 baseline characteristics. Fine–Gray competing risk regression was used to estimate the risk of fall and fracture.

Results

The study cohort comprised of 2205 new baclofen users, 1103 new tizanidine users, and 9708 new cyclobenzaprine users. During a median follow‐up of 100 days, baclofen was associated with a higher risk of fall compared to tizanidine (IPTW incidence rate, 108.4 vs. 61.9 per 1000 person‐years; subdistribution hazard ratio [SHR], 1.68 [95% CI, 1.20–2.36]). The risk of fall associated with baclofen was comparable to cyclobenzaprine (SHR, 1.17 [95% CI, 0.93–1.47]) with a median follow‐up of 106 days. The risk of fracture was similar among patients treated with baclofen versus tizanidine (SHR, 0.85 [95% CI, 0.63–1.14]) or cyclobenzaprine (SHR, 0.85 [95% CI, 0.67–1.07]).

Conclusions

The risk of fall associated with baclofen was greater than tizanidine, but not compared to cyclobenzaprine in older adults. The risk of fracture was comparable among the older users of baclofen, tizanidine, and cyclobenzaprine. Our findings may inform risk‐benefit considerations in the increasingly common clinical encounters where oral muscle relaxants are prescribed.
Diverse signaling mechanisms and heterogeneity of astrocyte reactivity in Alzheimer's disease
Authors: Qin Hongwei , Zhou Lianna , Haque Faris T. , Martin‐Jimenez Cynthia , Trang Amy , Benveniste Etty N. , Wang Qin
Published: November 2023

Alzheimer's disease (AD) affects various brain cell types, including astrocytes, which are the most abundant cell types in the central nervous system (CNS). Astrocytes not only provide homeostatic support to neurons but also actively regulate synaptic signaling and functions and become reactive in response to CNS insults through diverse signaling pathways including the JAK/STAT, NF‐κB, and GPCR‐elicited pathways. The advent of new technology for transcriptomic profiling at the single‐cell level has led to increasing recognition of the highly versatile nature of reactive astrocytes and the context‐dependent specificity of astrocyte reactivity. In AD, reactive astrocytes have long been observed in senile plaques and have recently been suggested to play a role in AD pathogenesis and progression. However, the precise contributions of reactive astrocytes to AD remain elusive, and targeting this complex cell population for AD treatment poses significant challenges. In this review, we summarize the current understanding of astrocyte reactivity and its role in AD, with a particular focus on the signaling pathways that promote astrocyte reactivity and the heterogeneity of reactive astrocytes. Furthermore, we explore potential implications for the development of therapeutics for AD. Our objective is to shed light on the complex involvement of astrocytes in AD and offer insights into potential therapeutic targets and strategies for treating and managing this devastating neurodegenerative disorder.
Subsidizing housing with deductions
Authors: Valentin Maxence
Published: November 2023

Many governments subsidize owner‐occupied housing by allowing households to deduct housing expenses from their taxable incomes. While these deductions provide considerable financial benefits to homeowners, they also have significant downstream consequences. This article synthesizes a large body of literature that assesses these implications on various aspects of the housing market, including mortgage demand, interest rates, tenure decisions, homeownership rates, housing prices, and welfare. The findings in the literature collectively emphasize the distortive impact of these fiscal deductions on housing consumption and investment, with a growing consensus regarding the deductions' regressivity and negative effects on homeownership rates and welfare.
Concurrent invasions of European starlings in Australia and North America reveal population‐specific differentiation in shared genomic regions
Authors: Hofmeister Natalie R. , Stuart Katarina C. , Warren Wesley C. , Werner Scott J. , Bateson Melissa , Ball Gregory F. , Buchanan Katherine L. , Burt David W. , Cardilini Adam P. A. , Cassey Phillip , De Meyer Tim , George Julia , Meddle Simone L. , Rowland Hannah M. , Sherman Craig D. H. , Sherwin William B. , Vanden Berghe Wim , Rollins Lee Ann , Clayton David F.
Published: November 2023

A species' success during the invasion of new areas hinges on an interplay between the demographic processes common to invasions and the specific ecological context of the novel environment. Evolutionary genetic studies of invasive species can investigate how genetic bottlenecks and ecological conditions shape genetic variation in invasions, and our study pairs two invasive populations that are hypothesized to be from the same source population to compare how each population evolved during and after introduction. Invasive European starlings (Sturnus vulgaris) established populations in both Australia and North America in the 19th century. Here, we compare whole‐genome sequences among native and independently introduced European starling populations to determine how demographic processes interact with rapid evolution to generate similar genetic patterns in these recent and replicated invasions. Demographic models indicate that both invasive populations experienced genetic bottlenecks as expected based on invasion history, and we find that specific genomic regions have differentiated even on this short evolutionary timescale. Despite genetic bottlenecks, we suggest that genetic drift alone cannot explain differentiation in at least two of these regions. The demographic boom intrinsic to many invasions as well as potential inversions may have led to high population‐specific differentiation, although the patterns of genetic variation are also consistent with the hypothesis that this infamous and highly mobile invader adapted to novel selection (e.g., extrinsic factors). We use targeted sampling of replicated invasions to identify and evaluate support for multiple, interacting evolutionary mechanisms that lead to differentiation during the invasion process.
The war in Ukraine and the ambivalent figure of ‘Babushka’: Intersectional nation‐building and the delegitimisation/legitimisation of war on YouTube
Authors: Lönnroth‐Olin Marja , Venäläinen Satu , Menard Rusten , Pauha Teemu , Jasinskaja‐Lahti Inga
Published: November 2023

In this article, we demonstrate how international social‐media discussions offer a platform for taking a stance on the war in Ukraine, redrawing national boundaries and legitimising their defence. We do so by analysing data that consist of comments triggered by a viral YouTube video depicting an encounter between an ageing civilian woman, labelled ‘Babushka Z’, and a Ukrainian soldier. Using a critical discursive psychological framework, we identify five interpretative repertoires: vulnerability, incapacity, national continuity, masculinised warriorship and righteousness. Our analysis illuminates how these repertoires draw on and reproduce intersecting categorisations based on gender, age and ethnic heritage. With the help of these categorisations, the repertoires build competing images of the actions of the figures in the video, which come to symbolise in various ways both patriotism and treason, heroism and cowardice. By aligning with competing historical‐national narratives, the commentors use these images to (de)legitimise the war and its actors.
Total pragmatic encroachment and belief–desire psychology
Authors: Langford Simon
Published: November 2023

Pragmatic encroachment in epistemology is the idea that whether one knows some proposition depends on whether one can rely on it practically. Total pragmatic encroachment affirms that practical considerations of this sort encroach not just on knowledge but on all interesting normative epistemic statuses a belief might have. Ichikawa, Jarvis, and Rubin (2012) have argued that this stronger thesis conflicts with mainstream belief‐desire psychology. Worse still, they argue that attempting to defend the thesis gets one caught in vicious circularities. The aim of this paper is to show that, if we are careful in how we understand the key idea of being sensitive to practical considerations, we can defend total pragmatic encroachment and avoid the circularities. In fact, depending on how it is understood, we can even square mainstream belief‐desire psychology with total pragmatic encroachment as well.
Identification of a novel MICB allele, MICB*014:02, by cloning and sequencing
Authors: Zhang Zhan‐Fa , Zhang Zhi‐Yue , Deng Yan , Wang Qing‐Ming , Zhu Wei‐Feng
Published: November 2023

The novel MICB*014:02 allele differs from MICB*014:01:01 by one nucleotide change in exon 2.
Longitudinal Wave Propagation in an Elastic Cylinder Embedded in a Viscoelastic Fluid
Authors: Aninou Mohamed , El Baroudi Adil , Le Pommellec Jean Yves
Published: November 2023

A novel analytical investigation of longitudinal wave propagation in an elastic cylinder embedded in a viscoelastic fluid is proposed. The Maxwell model is used to describe the viscoelastic fluid behavior. With appropriate boundary conditions, a complex dispersion equation of longitudinal waves has been established. The aim of this paper is to study the effect of the fluid rheological properties on the longitudinal wave characteristics (attenuation and velocity). It is shown that the attenuation is the sum of a viscous and nonviscous component. The viscosity-induced attenuation is predominant at low frequencies. On the other hand, the effect of the liquid amount and elastic cylinder radius on the attenuation and velocity are studied. A critical normalized liquid thickness is highlighted. Beyond this critical value, the influence of the outer boundary condition can be neglected. At last, among other interesting phenomena, it is highlighted that if the Deborah number increases, the attenuation decreases. This variation characterizes a stiffening of the viscoelastic medium. In addition, the obtained results show that the viscosity measurement should be performed at low frequencies using a small elastic cylinder radius. Accordingly, these investigations are novel and can be applied in geophysics, the food industry, medicine, nondestructive testing of materials, and the design and development of fluid sensors.
Player Perceptions of Face Validity and Fidelity in 360-Video and Virtual Reality Cricket
Authors: Runswick Oliver R.
Published: November 2023

Virtual reality (VR) and 360° video can provide new opportunities for testing and training in sport. Both options offer different benefits in terms of efficacy for training, ease of use, and cost. This creates questions about the implementation of immersive technologies, and research is required to further understand their use. We aimed to gain initial evidence of athletes’ perceptions of face validity and fidelity in VR and 360-video. Thirty-nine international pathway cricketers experienced five overs in VR cricket and in a 360-video recording. After trying each technology, players completed questionnaires to measure perceptions of presence and task workload. Participants reported immersive experience in both methods, but higher levels of realism, possibility to act, physical effort, temporal constraints, and task control in VR. 360-video offers a better possibility to visually examine the environment, while VR offers enhanced realism and physical elements, but 360-video may still offer affordable solutions for visual tasks.
Complete genome sequence of bacteriophage MrAaronian isolated from an
Arthrobacter globiformis
culture
Authors: Haines Ian , Blakely Jessica , Branson Ashley , Estrada Diana , Fernandez Robles Rebeca , Fitzgerald Katelyn , Jeffers Shelby , Leung Timyee , Munoz Jasmine , Olivos Ashley , Ramirez Anayeli , Smith Caressa , Spere Justin , Tavarez Idaleth , Wood Isabella , Zavala Ethan , Arrighi Madison , Coronel-Galindo Angelica , Dennis Megan K. , Goppert Marlee , Edwards Dustin
Published: November 2023

Arthrobacteriophage MrAaronian contains a 54,509 bp DNA genome with 87 predicted protein-coding genes. MrAaronian has siphovirus morphology and was collected from a flowerbed soil sample in Poughkeepsie, NY, and isolated on an
Arthrobacter globiformis
B-2979 culture. MrAaronian has > 99% nucleotide identity with cluster AW arthrobacteriophages Michelle, Stayer, Sloopyjoe, and StarLord.
Complete genome sequence of
Erythrobacteraceae
bacterium WH01K, a strain isolated from corals (
Acropora
sp.) in Taiwan
Authors: Hung Shih-Hsun Walter , Wu I-Chen , Huang Chieh-Chen , Kuo Chih-Horng
Published: November 2023

Here, we report the isolation and genome sequence of a coral-associated
Erythrobacteraceae
bacterium, strain WH01K. The complete assembly consists of one 2,745,896 bp circular chromosome and one 172,502 bp circular plasmid.
Viscoelastic effect on the triple diffusive oscillatory flow in a fluid-saturated porous layer
Authors: Alhefthi Reem K. , Vinod Y. , Raghunatha K. R. , Pallavi G. , Inc Mustafa
Published: November 2023

The combined heat and mass transfer, the so-called thermosolutal convective problem, has become an attractive field of research in many diversified areas. In this paper, for the first time, oscillatory flow analysis has been carried out for triple diffusive viscoelastic fluid flow in a porous medium. A comprehensive model is developed for the modified Darcy–Brinkman–Oldroyd-B fluid, porous medium, Boussinesq approximation, heat and mass transfer across a finite temperature and concentration difference in the chemical potential of two salts. Triple diffusive viscoelastic fluid flows through porous media have grown significantly as this situation occurs in more than a few applications such as improved oil recovery filtration, liquid complex molding, solidification of liquid crystals, cooling of metallic plate in a bath, exotic lubricants and colloidal solutions, polymer processing, chemical and bioengineering industries, among others. The governing coupled nonlinear partial differential equations with boundary constraints represent the modeled flow problem. In addition, these equations are converted into non-dimensional form by employing suitable non-dimensionalizing quantities. The impacts of the pertinent parameters and related dimensionless numbers on the dimensionless velocity, temperature, concentrations, shear stress, heat and mass transfer are examined for both suction and injection cases. It has been found that when the injection level on the heated plate is increased, the shear rate increases for each channel plate. Furthermore, we recognized that the viscoelastic parameters exhibit an opposite kind of behavior on the velocity, temperature, and concentrations fields.
Efficient Quantum Algorithms for Testing Symmetries of Open Quantum Systems
Authors: Bandyopadhyay Rahul , Rubin Alex H. , Radulaski Marina , Wilde Mark M.
Published: November 2023

Symmetry is an important and unifying notion in many areas of physics. In quantum mechanics, it is possible to eliminate degrees of freedom from a system by leveraging symmetry to identify the possible physical transitions. This allows us to simplify calculations and characterize potentially complicated dynamics of the system with relative ease. Previous works have focused on devising quantum algorithms to ascertain symmetries by means of fidelity-based symmetry measures. In our present work, we develop alternative symmetry testing quantum algorithms that are efficiently implementable on quantum computers. Our approach estimates asymmetry measures based on the Hilbert–Schmidt distance, which is significantly easier, in a computational sense, than using fidelity as a metric. The method is derived to measure symmetries of states, channels, Lindbladians, and measurements. We apply this method to a number of scenarios involving open quantum systems, including the amplitude damping channel and a spin chain, and we test for symmetries within and outside the finite symmetry group of the Hamiltonian and Lindblad operators.
SpatialEpi'2022 Workshop Report: The 3rd ACM SIGSPATIAL International Workshop on Spatial Computing for Epidemiology
Authors: Anderson Taylor , Kim Joon-Seok , Roess Amira , Züfle Andreas
Published: November 2023

Since the onset of the COVID-19 pandemic, researchers in the SIGSPATIAL community have utilized computational solutions to better explain, predict, and respond to infectious disease outbreaks. Using spatial computing for pandemic preparedness has also been highlighted as a major application of mobility data science [16]. At the beginning of the COVID-19 pandemic, the SIGSPATIAL community rapidly published ideas to improve our understanding of the spread of the virus in two SIGSPATIAL Special Newsletter Issues in March and July 2020 [28, 29]. These efforts led to the 1st and 2nd ACM SIGSPATIAL International Workshop on Spatial Computing for Epidemiology [5, 4] (formerly called Workshop on Modeling and Understanding the Spread of COVID-19 in 2020) which has provided authors of these newsletter articles a forum to present and discuss their solutions. Including both work published at the SIGSPATIAL Special Newsletter and regular peer-reviewed submissions, this workshop included topics such as the collection of large spatiotemporal datasets [20], leveraging data mining and spatial analysis techniques to analyze and visualize such data [2, 12, 25, 21, 11, 9, 8, 3], developing predictive spatial models and simulations [6, 1, 19, 13, 24, 10, 23, 14], and employing novel technologies towards contact tracing and surveillance [17, 26].
The First Female Networking Event
Authors: Kim Jina , Namgung Min
Published: November 2023

Today, many top conferences in computer science hold workshops and social events to promote women's role in their field. One of the events is Women in Machine Learning (WiML) Workshop, co-located with NeurIPS '19 [1]. Their mission is to "create opportunities for women to engage in substantive technical and professional conversations in a positive, supportive environment." Other related events include "Women in Artificial Intelligence and Machine Learning for Mental Health Applications" at ICML '22 [3] and "Women in Computer Vision" at CVPR '22 [4].
Clostridium scindens exacerbates experimental necrotizing enterocolitis via upregulation of the apical sodium-dependent bile acid transporter
Authors: Calton Christine M. , Carothers Katelyn , Ramamurthy Shylaja , Jagadish Neha , Phanindra Bhumika , Garcia Anett , Viswanathan V. K. , Halpern Melissa D.
Published: November 2023

Necrotizing enterocolitis (NEC), a life-threatening gastrointestinal emergency in premature infants, is characterized by dysregulation of bile acid homeostasis. We demonstrate that administering the secondary bile acid-producing bacterium Clostridium scindens enhances NEC in a neonatal rat model of the disease. C. scindens-enhanced NEC is dependent on bile acids and driven by upregulation of the ileal bile acid transporter Asbt. This is the first report of bile acid-modifying bacteria exacerbating experimental NEC pathology.
A Comparative Analysis of Traditional SARIMA and Machine Learning Models for CPI Data Modelling in Pakistan
Authors: Qureshi Moiz , Khan Arsalan , Daniyal Muhammad , Tawiah Kassim , Mehmood Zahid
Published: November 2023

Background. In economic theory, a steady consumer price index (CPI) and its associated low inflation rate (IR) are very much preferred to a volatile one. CPI is considered a major variable in measuring the IR of a country. These indices are those of price changes and have major significance in monetary policy decisions. In this study, different conventional and machine learning methodologies have been applied to model and forecast the CPI of Pakistan. Methods. Pakistan’s yearly CPI data from 1960 to 2021 were modelled using seasonal autoregressive moving average (SARIMA), neural network autoregressive (NNAR), and multilayer perceptron (MLP) models. Several forms of the models were compared by employing the root mean square error (RMSE), mean square error (MSE), and mean absolute percentage error (MAPE) as the key performance indicators (KPIs). Results. The 20-hidden-layered MLP model appeared as the best-performing model for CPI forecasting based on the KPIs. Forecasted values of Pakistan’s CPI from 2022 to 2031 showed an astronomical increase in value which is unpleasant to consumers and economic management. Conclusion. The increasing CPI trend observed if not addressed will trigger a rising purchasing power, thereby causing higher commodity prices. It is recommended that the government put vibrant policies in place to address this alarming situation.
Explaining Nursing Managers’ Understanding of Value Creation: A Qualitative Study
Authors: Akbari Ayob , Mahmoudirad Gholamhosein
Published: November 2023

Introduction. Value creation can begin through a joint development process. Value creation not only relies on interactions between group members but also requires studying other attributes. This study aimed to explain the experiences of nursing managers regarding value creation in nursing. Methods. A descriptive content analysis approach was used in this study. Sampling was done purposefully from April to December 2022 among the nursing managers working in Birjand educational hospitals who were willing to participate in the study. Data were collected through unstructured interviews. Graneheim and Lundman’s (2020) qualitative content analysis method was used to analyze the data, and four Lincoln and Guba criteria were used for the data rigor process. All interviews were recorded, typed in a Word file, and entered into MAXQDA (2020). Twenty-two interviews were conducted with nineteen participants. Results. In this study, eleven participants were female, and eight were male. They were employed at three different management levels, including head nurses, supervisors, and matrons. The data analysis has resulted in the identification of ten distinguished subcategories, which have been grouped into four categories based on their similarities. These four categories are concerned with value-seeking, purposeful identification of values, determining strategies to grow values, and perpetuation of values. Conclusion. By prioritizing value creation and emphasizing its importance, nursing managers can effectively improve patient outcomes and enhance the overall quality of care provided in healthcare organizations. Additionally, nursing managers play a crucial role in facilitating and maintaining values in the organization by contextualizing opportunities for the flourishing of value and directing them towards valuable benefits. Therefore, it is essential that nursing managers have a correct understanding of nursing values and value creation in nursing practice.
Supplementary Table 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Authors: Tang Wei , Zhang Flora , Byun Jung S. , Dorsey Tiffany H. , Yfantis Harris G. , Ajao Anuoluwapo , Liu Huaitian , Pichardo Margaret S. , Pichardo Catherine M. , Harris Alexandra R. , Yang Xiaohong R. , Figueroa Jonine D. , Sayed Shahin , Makokha Francis W. , Ambs Stefan
Published: November 2023

Patient characteristics for NCI-Maryland cohort.
Supplementary Figure 5 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Authors: Tang Wei , Zhang Flora , Byun Jung S. , Dorsey Tiffany H. , Yfantis Harris G. , Ajao Anuoluwapo , Liu Huaitian , Pichardo Margaret S. , Pichardo Catherine M. , Harris Alexandra R. , Yang Xiaohong R. , Figueroa Jonine D. , Sayed Shahin , Makokha Francis W. , Ambs Stefan
Published: November 2023

Supplementary Figure 5 shows neighborhood deprivation and its association with mutational signatures.
FIGURE 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Authors: Tang Wei , Zhang Flora , Byun Jung S. , Dorsey Tiffany H. , Yfantis Harris G. , Ajao Anuoluwapo , Liu Huaitian , Pichardo Margaret S. , Pichardo Catherine M. , Harris Alexandra R. , Yang Xiaohong R. , Figueroa Jonine D. , Sayed Shahin , Makokha Francis W. , Ambs Stefan
Published: November 2023

Neighborhood deprivation and its association with mutational signatures. A, Relationship of the NDI with race/ethnicity, household income, BMI, age, disease stage, tumor ER status, and tumor TP53 and TBX3 mutational status, in the NCI-Maryland breast cancer cohort. NDI for the analysis was obtained for each patient in the study using 2000 census data and correlated with patient or tumor characteristics. Significant associations with race, household income, and TP53 and TBX3 mutational status (P < 0.05 with t test or one-way ANOVA). B, Correlation matrix for the relationship of patients’ 1990 and 2000 NDIs with six COSMIC-based mutational signatures in their tumors. NDI shows a moderate inverse correlation with the SBS2 signature.
Effects of Two Cannabidiol Oil Products on Self-Reported Stress Relief: A Quasi-Experimental Study
Authors: Faraj Mohammed , Dautrich Tyler , Lundahl Leslie , Marusak Hilary
Published: November 2023

Introduction: Estimated rates of past-month cannabidiol (CBD) use in the general public are 13–26% and emerging research examines CBD as a potential adjunct treatment for several medical conditions, including stress-related disorders (e.g., depression, anxiety, and chronic pain). However, little is known about the effects of different CBD products on self-reported stress. The present study compared the effects of two delta-9-tetrahydrocannabinol (THC)-free CBD tincture products – (1) an isolate CBD oil and (2) a broad spectrum CBD oil – on self-ratings of effectiveness of the product and ability to manage stress. Methods: This quasi-experimental study reports on a total of 374 participants who completed either a 30- or 60-day regimen. Participants were instructed to use a 1,000 mg CBD isolate product at will, and then switch over to a 1,000 mg broad spectrum product for the remainder of the regimen (i.e., next 15 or 30 days). Self-reported effectiveness of the product and its ability to help manage stress was compared between the isolate and broad spectrum products. We also examined overall impression, quality, taste, and adverse effects of each product. Results: Overall, both products were rated to be highly effective and able to assist with stress management. Participants reported that the broad spectrum product’s effectiveness (p < 0.001) and ability to reduce stress (p < 0.001) as greater than the isolate product across both regimens. However, participants preferred the taste of the isolate product over that of the broad spectrum across regimens (p < 0.05). For the 30-day regimen, participants reported a more positive overall impression of the isolate as compared to the broad spectrum (p < 0.001); however, overall impression did not differ between the products in the 60-day regimen. There was no difference in adverse effects or quality between the products, across both regimens. Conclusion: These results fit with prior studies suggesting anti-stress effects of CBD. Ratings were higher for the broad spectrum as compared to the isolate product, which is consistent with prior data suggesting that cannabinoids can work synergistically to maximize benefits. Nonetheless, more controlled studies are needed to explore these effects in nonclinical and clinical populations.
The Efficacy of Budesonide, Levocabastine, and Their Combination in Treatment of Vasomotor Rhinitis
Authors: Tan Ruyu , Meng Yifan , Wang Yang , Zhang Lili , Wang Chengshuo , Zhang Luo
Published: November 2023

Introduction: Relevant studies have demonstrated that glucocorticoids and antihistamines, such as budesonide and azelastine, are effective in the treatment of vasomotor rhinitis, with their combined use being more effective than that of a single drug. The aim of this study was to assess the improvement in the symptoms of patients following the combined administration of these drugs. Methods: We conducted a single-center randomized study on 42 patients. Participants were randomly treated with budesonide, levocabastine hydrochloride, or their combination for 2 weeks. The visual analog scale (VAS) score and levels of eosinophil cationic protein (ECP), histamine (HA), leukotriene B4 (LTB4), and vasoactive intestinal peptide (VIP) in nasal secretions were evaluated before and after treatment. Results: The symptoms of patients were improved in all 3 treatment groups compared with those before treatment. Following combined treatment, the improvement in symptoms of nasal obstruction, runny nose, nasal itching, and sneezing was much greater than those in the groups treated with budesonide or levocabastine hydrochloride alone (p = 0.04, 0.004, 0.005, 0.004, respectively). The decreased levels of these inflammatory mediators were significantly different between the different treatment groups. Conclusions: Budesonide or levocabastine hydrochloride alone improved the nasal symptoms of patients with vasomotor rhinitis and reduced the levels of ECP, HA, LTB4, and VIP in nasal secretions. However, their combination improved the symptoms of patients more significantly than each drug alone.
Proteins in the Skin and Blood in Patients with Psoriasis: A Systematic Review of Proteomic Studies
Authors: Kromann Bjørn , Olsson Anna , Zhang Ying Marlene , Løvendorf Marianne Bengtson , Skov Lone , Dyring-Andersen Beatrice
Published: November 2023

Background: Proteins play a central role in psoriasis as they are involved in the structural phenotypic changes and inflammation that characterize the disease. This systematic review aimed to assess which proteins have been consistently reported as upregulated or downregulated in the skin and blood from patients with psoriasis. Methods: We included proteomic studies reporting differentially expressed proteins (DEPs) in at least one of four predefined comparisons using a standardized procedure to extract and align data. Network analysis of functional protein associations was made with StringApp in Cytoscape. A protocol for this review was registered in the PROSPERO database (ref:CRD42022363226). Results: We identified and assessed 772 studies published between December 2, 1996, and April 28, 2023, among which 30 studies met the inclusion and data availability criteria for analysis that together reported a sum of 5,314 DEPs. The majority of consistently reported upregulated and downregulated proteins were found in lesional versus non-lesional skin (n = 313), followed by lesional versus healthy skin (n = 185), blood from patients with psoriasis versus blood from healthy individuals (n = 140), and non-lesional versus healthy skin (n = 1). Network analysis of upregulated proteins revealed different functional clusters with interleukin (IL)-6, IL-8, IL-17A, C-C motif chemokine (CCL) 20, signal transducer and activator of transcription (STAT) 3, and interferon (IFN)-γ along with less well-studied proteins playing central roles. Some of the reported changes are associated with anti-inflammatory effects. Additionally, the proteomic dysregulation also included antimicrobial peptides, alarmins, angiogenic factors, and proteins related to protein synthesis. Conclusion: Our findings generally support current understandings of the pathological mechanisms in psoriasis. Importantly, some consistent findings have not been discussed before and deserve attention in future research.
Piaget’s Paradox: Adaptation, Evolution, and Agency
Authors: Walsh Denis
Published: November 2023

Piaget’s Behaviour and Evolution (1976) sought to reconcile the view that organismal adaptiveness – in the form of equilibration – could contribute to human behavioural, cognitive, and epistemic evolution with the prevailing evolutionary orthodoxy of the time. He was particularly concerned to demonstrate that human behaviour, cognition, and knowledge acquisition could be drivers of human evolution. Piaget hypothesised constructive role for organisms in evolution was significantly at variance with the prevailing modern synthesis orthodoxy of his time (and ours). He looked to Conrad Hal Waddington’s genetic assimilation as a model for how equilibration could generate evolutionary novelties which become fixed by subsequent evolution. I make two claims. Firstly, that Piaget’s appeal to Waddington fails to reconcile his views of human evolution with the modern synthesis. Secondly, the newly emerging agential conception of evolution, in which the purposive activities of organisms are the principal causes of evolution, offers strong support to Piaget’s model of “organisational” evolution.
Metastatic Colon Cancer – An Effective Treatment Protocol of Integrative Therapies Including Electromagnetic Field Frequencies: A Case Report
Authors: Ried Karin , Eng Peter , Binjemain Taufiq
Published: November 2023

Introduction: Colorectal cancer is the third most common cancer worldwide, with 25% of patients being diagnosed with metastatic disease, mostly in the liver, resulting in poor survival. Standard treatment of stage-IV colorectal cancer consists of primary tumour resection followed by chemotherapy. Case Presentation: Here, we report on the treatment effectiveness using integrative therapies in a 52-year-old male with metastatic colon cancer and liver lesions to achieve stable partial remission with an overall high level of wellbeing. After surgical removal of the primary tumour, the 8-month integrative treatment regime consisted of standard anti-angiogenesis treatment, as well as multiple non-standard but evidence-based therapies, including high-dose intravenous nutrients and herbal therapies, oral intake of repurposed medication and nutritional supplements, and a 4-month targeted electromagnetic field/Rife frequency therapy. Conclusion: The integrative therapies used in this case study were highly tolerable and effective in the treatment of metastatic colon cancer with liver lesions, achieving substantial tumour response and stable partial remission with a high level of wellbeing.
Survival Benefit and Cost Effectiveness of a Future Blood‐Based Diagnostic Test to Detect Cerebral Aneurysm Formation
Authors: Mittal Aditya M. , Nowicki Kamil W. , Dembinski Robert , Alattar Ali , McDowell Michael M. , Lang Michael P. , Gross Bradley A. , Friedlander Robert M.
Published: November 2023

Background

Cerebral aneurysms are common, but there is no blood test for their diagnosis. Cerebral aneurysms are diagnosed incidentally or upon rupture. Current diagnostic tools either are invasive or place a large financial burden on the patient. Introduction of a blood test can reduce costs and allow for additional screening.

Methods

Markov decision analytic models were created for different case studies to simulate management within the US health care system. The model was run over 50 cycle‐years. Probabilities, costs, and outcomes were obtained from the literature and the National Inpatient Sample database. Quality‐adjusted life years were used to assess outcomes. Subgroup analysis was performed for different risk factors, patient groups, aneurysm size, and family members.

Results

A blood‐based diagnostic pathway is more cost effective in patients undergoing watchful waiting and as a screening tool in patients who may be at a higher risk. There was a 3‐fold reduction in death compared with the standard of care (15.71% versus 53.10%). The cost of using a blood test per additional quality‐adjusted life year gained was $34 515.13 among the watchful‐waiting cohort. The threshold price was $3951. Among patients with 1 family member with an aneurysm, we observed a 10‐fold reduction in death compared with the standard of care (0.21% versus 2.35%), with a threshold at $845.77. Among patients who smoke, we observed a 10‐fold reduction in death compared with the standard of care (0.27% versus 3.30%) with a threshold at $1054.24. Among patients with 2 family members with an aneurysm, there was a 10‐fold reduction in death compared with the standard of care (0.48% versus 5.85%) with a threshold at $1876.46.

Conclusion

Introduction of a blood‐based test for cerebral aneurysms would have a lifesaving effect within the US health care system while remaining cost effective.
Environmentality: A Phenomenology of Generative Space in Husserl
Authors: DuFour Tao
Published: November 2023

This article explores aspects of the theory of the constitution of space in the work of Edmund Husserl that appear in his late, posthumously published writings on the themes of intersubjectivity and generativity, which the article proposes imply a theory of environmental experience. It identifies and examines Husserl’s use of the locution Umweltlichkeit as it appears in these late works, proposing a rendering of this term as environmentality. This concept, the article argues, functions operatively in Husserl’s late work, indicating a relationship between his descriptions of the lived bodily constitution of spatiality and his conception of the spatio-environmental nature of the intersubjective and historical becoming of human community. In this way, the article proposes that through the concept of environmentality, Husserl articulates a phenomenological conception of the generativity of space.
State Obligation in the East China Sea: Unilateral Activities and Countermeasures
Authors: Ni Tingting , Choi Junghwan , Qi Jiancuo
Published: November 2023

Maritime disputes among the East Asian States have garnered increasing attention worldwide with expanding offshore activities in the East China Sea. To avoid confrontation and potential conflict, unilateral maritime claims in the East China Sea usually have been non-explicit. While maritime boundary disputes remain unresolved in the region, changes have taken place because of resource shortages, the rise in military assertiveness from Tokyo, and increased alliances with the United States. This article explores the limits of unilateral activities within the disputed maritime area under current international law and how East Asian States should behave when they encounter unilateral activities conducted by other States, including analysis on sovereign entitlement and the limits of unilateral activities in the region. A code of conduct among the East Asian States is needed to ensure peace and prosperity in the region.
“Thanks for Getting Me in Touch with Local Politicians!”
Authors: Santarromana Emmanuel , 王 思萌
Published: November 2023

This article focuses on the political engagement and professionalization of French youth of Chinese origin through a case study of the Association of Young Chinese in France (Association des Jeunes Chinois de France, AJCF), acting as a springboard toward political professionalization. It relies on several qualitative studies recently carried out in the Paris region, with French associative and political actors of Chinese origin. After analyzing the raising of awareness regarding anti-Asian racism as a key factor in the political socialization and engagement of French Chinese youth, the article shows that being a leading member of the AJCF allows one to build a social network of contacts among political actors and affirms that this acquired political capital is one of the catalysts for being identified and recruited by political authorities at the local level, as a step toward the development of an electoral career.
The Refugee-Migrant Distinction and the Need for Bridging Analytical Divides in the Historiography
Authors: Langrognet Fabrice
Published: November 2023

This epistemological article discusses the existing and potential historiographic connections between the history of refugees and migration history, which are increasingly regarded as two separate fields of knowledge. It focuses on how this dialogue could help scholars overcome the analytical divisions between migrants and refugees through decentred and self-reflexive approaches. By drawing on the overlooked familiarity of migration historiography with refugees and on its robust experience with deconstructionist challenges, historians have all the tools to historicise ‘refugee-ing’ processes instead of essentialising the ‘refugee experience’ and reinforcing unwarranted epistemic separations. In crafting new analytical models to this effect, historians will have to reckon with the colonial genealogy of contemporary refugee-making.