bluuebunny/crossref_metadata_2025 huggingface dataset:
КЛІНІЧНИЙ ВИПАДОК ЕНДОСКОПІЧНОГО ВИДАЛЕННЯ ФІБРОМИ ТРАХЕЇ
Authors: Malovanyy V. V. , Viytovych L. E. , Sanotska M. V.
Published: December 2020

Частота первинних пухлин трахеї становить менше ніж 0,1 %. Нерідко їх неправильно діагностують як астму або хронічне захворювання легень, що відстрочує лікування на місяці або роки.

Як клінічний приклад можна розглянути випадок фіброми трахеї з нашої практики. Пацієнтка, 40 років, була направлена у відділення пульмонології КНП «Тернопільська університетська лікарня» ТОР з діагнозом тяжкої рефрактерної бронхіальної астми. Незважаючи на інтенсивне протиастматичне лікування, показники спірометрії поступово погіршувалися. Для уточнення діагнозу пацієнтці проведена комп’ютерна томографія органів грудної клітки та виявлено пухлиноподібний утвір у просвіті трахеї. Хвору з діагнозом пухлини трахеї терміново направили у відділення торакальної хірургії для подальшої діагностики та лікування. Хірургічне лікування проводили з використанням гнучкого фібробронхоскопа під місцевою анестезією. Ендоскопічну діатермічну петлю через канал бронхоскопа накидали на основу пухлини. Для відсікання застосовували електрохірургічний апарат Olympus UES-30 в послідовному режимі коагуляції 30 Вт і в режимі різання 25 Вт. При цьому пухлина прилипала до ендоскопічної петлі і видалялась разом із бронхоскопом.

Післяопераційний перебіг без ускладнень, протягом періоду спостереження нападів задишки не спостерігалося, нормалізувались показники спірометрії.

Висновки. Невелика частота клінічних випадків новоутворень трахеї у практиці лікаря терапевтичного профілю приводить до низької настороженості відносно даної патології. Труднощі у діагностиці зумовлені малою інформативністю клінічної картини на стадії початкової симптоматики. Вчасне встановлення діагнозу дає можливість провести ендоскопічне втручання, яке приводить до повного одужання пацієнта.
ВПЛИВ ПЕПТИДОГЛІКАНУ ЗОЛОТИСТОГО СТАФІЛОКОКА НА СПОНТАННУ СКОРОТЛИВУ АКТИВНІСТЬ МІОМЕТРІЯ ВАГІТНИХ ЩУРІВ
Authors: Nasibian L. S. , Philippov I. B. , Shuba Ya. M.
Published: December 2020

Пептидоглікан Золотистого стафілокока – структурний елемент бактеріальної клітинної стінки, який вивільнюється протягом життєдіяльності мікроорганізму та розноситься кровотоком по організму. Осідаючи на тропних клітинах він реалізує патогенні та імуногенні властивості. Золотистий стафілокок досить часто висівається із сечостатевої системи жінок. Відомо, що взаємодія пептидоглікану з ендотеліальними та децидуальними клітинами матки під час вагітності ініціює такі ускладнення, як прееклампсія, стимуляція скоротливості активності матки, передчасне переривання вагітності. Однак досі достеменно не вивчені механізми дії пептидоглікану на міометрій.

Мета – визначити, чи впливає пептидоглікан на спонтанну скоротливість міометрія вагітних щурів за умов відсутності ендометрія, вивчити характер спонтанних скорочень міометрія вагітних щурів під дією пептидоглікану та механізми виявлених ефектів.

Матеріал і методи. Досліди проводили на гладеньком’язових смужках міометрія вагітних щурів лінії Вістар. Скоротливість міометрія вивчали методом тензометрії.

Результати. Результати експериментів показали, що, пептидоглікан модулює всі основні параметри спонтанних маткових скорочень за умов відсутності ендометрія. Він збільшував амплітуду та тривалість скорочень у середньому на 18,5 % та 16 %, відповідно. Водночас частота спонтанних скорочень зменшилась у середньому на 10,5 %. Ряд параметрів скорочень міометрія свідчить про збільшення їх інтенсивності під дією пептидоглікану. Крім того, змінювалось співвідношення фаз скорочень міометрія: під дією пептидоглікану спонтанні скорочення міометрія мали відносно коротку, але високоамплітудну фазу скорочення, досить тривалий тонічний компонент та повільне розслаблення. Вказані фази скорочення міометрія на тлі дії пептидоглікану збільшились у середньому на 11,26 %, 69,23 % та 44,34 % відповідно. На тлі блокаторів потенціал керованих кальцієвих каналів L-типу та ІП3-рецепторів пептидоглікан не стимулював скорочення міометрія.

Висновки. Пептидоглікан має стимулювальну дію на спонтанну скоротливість міометрія шляхом впливу безпосередньо на міометрій. Модулювальний вплив пептидоглікану на скоротливість міометрія вагітних щурів пов’язаний зі збільшенням внутрішньоклітинного рівня кальцію в гладеньких міоцитах матки, що досягається завдяки посиленню трансмембранного входу кальцію та вивільненню із саркоплазматичного ретикулуму.
Збільшення ширини кератинізованих ясен та товщини м’яких тканин у периімплантатній ділянці: аналітичне опрацювання даних та результатів систематичних оглядів
Authors: Boychuk M. M. , Goncharuk-Khomyn M. Yu. , Cavalcanti A. L. , Lerner H.
Published: December 2020

Резюме. Відмінність в особливостях будови м’яких тканин навколо дентальних імплантатів,  порівняно зі структурою пародонта власних зубів, що визначається, зокрема паралельною орієнтованістю волокон відноcно поверхні трансмукозного абатмента та іншими характеристиками,  певною мірою знижує захисний потенціал периімплантатного м’якотканинного бар’єра, що в специфічних клінічних умовах при відповідних показаннях обґрунтовує доцільність проведення різних типів аугментаційних втручань.

Мета дослідження – проаналізувати дані систематичних оглядів та асоційованих досліджень, в яких висвітлено результати збільшення ширини кератинізованих ясен та товщини м’яких тканин у периімплантатній ділянці при використанні відповідних методів втручання та підходи до цільового вибору останніх.

Матеріали і методи.  Відповідно до поставленої мети дослідження в пошуковій базі Google Scholar та електронній базі даних PubMed здійснювався пошук наукових публікацій за ключовими словами («keratinized gingiva», «keratinized mucosa», «width», «soft tissue», «thickness», «peri-implant», «systematic review», «treatment method») та Mesh-термінами відповідно (алгоритм пошуку: implant[All Fields] AND keratinized[All Fields] AND («systematic review»[Publication Type] OR «systematic reviews as topic»[MeSH Terms] OR «systematic review»[All Fields]) AND («therapy»[Subheading] OR «therapy»[All Fields] OR «treatment»[All Fields] OR «therapeutics»[MeSH Terms] OR «therapeutics»[All Fields])).

Результати досліджень та їх обговорення. Проведений аналіз систематичних оглядів підтвердив, що успішність проведеної м’якотканинної аугментації дійсно залежить від особливостей маніпуляції та специфіки застосовуваних матеріалів. У ході планування проведення процедури м’якотканинної аугментації з метою збільшення ширини кератинізованих ясен та товщини м’яких тканин в периімплантатній ділянці доцільно враховувати клінічні рекомендації консенсусного рішення Osteology Foundation від 2018 р. та алгоритм диференційованого вибору методу втручання за Bassetti.

Висновки. Після опрацювання даних систематичних оглядів та асоційованих досліджень, в яких було наведено результати збільшення ширини кератинізованих ясен та товщини м’яких тканин після застосування різних підходів до м’якотканинної аугментації у периімплантатній ділянці, й встановлено, що реалізація технік апікально та коронально зміщених клаптів відповідно до комбінації із аутогенними сполучнотканинними трансплантатами або вільними ясенними графтами характеризується найвищим рівнем довгострокової прогнозованості результатів. Отримані в ході аналізу дані є недостатніми для статистичного обґрунтування вищої ефективності одного з методів,  порівняно з іншими, що також обґрунтовано гетерогенністю дизайнів проаналізованих досліджень та використанням різних видів критеріїв оцінки приросту ширини кератинізованих ясен та товщини м’яких тканин.
Динаміка активності фосфатаз у сироватці крові та гомогенаті тканин пародонта при експериментальному гінгівіті
Authors: Drevnitskaya R. A. , Gevkalyuk N. A. , Avdeev O. V.
Published: December 2020

Резюме. Унаслідок значного поширення запальних захворювань тканин пародонта актуальним питанням у стоматології залишається покращення результатів їх лікування та профілактики. Для розкриття ще не вивчених на сьогодні ланок патогенезу та проведення найефективнішого лікування оптимальним є дослідження перебігу біохімічних процесів при експериментальному гінгівіті та за його корекції.

Мета дослідження  – оцінити активність фосфатаз у сироватці крові та гомогенаті ясен при експериментальному гінгівіті й за його корекції у статевозрілих щурів.

Матеріали і методи. Досліди проведено на 100 білих нелінійних щурах-самцях віком 5–6 місяців: 10 інтактних щурів; 30 тварин з експериментальним гінгівітом без змін реактивності організму, 30 щурів з експериментальним гінгівітом на тлі гіпоергії організму, 30 тварин з експериментальним гінгівітом на тлі гіперергії організму, яким проводили лікування протизапальним гелем із неовітином. Забій тварин і забір крові та м’яких тканин пародонта під тіопенталовим наркозом проводили через 7 діб після початку експерименту в групі зі змодельованим гінгівітом, у групах без і з корекцією – через 14 діб.

Результати досліджень та їх обговорення. Встановлено, що зміни активності лужної фосфотази (ЛФ) у гомогенаті за корекції гінгівіту були наступними: зростання активності ЛФ спостерігали у нормо- і гіпоергічних щурів у 1,2 раза (р<0,05) і на 5,2 % (р>0,05) відповідно, у гіперергічній групі відбувалось зменшення активності ЛФ у 1,45 раза (р<0,05) порівняно з відповідними показниками щурів без корекції. Корекція протизапальним гелем із неовітином зменшувала активність кислої фосфотази (КФ) у гомогенаті ясен у всіх групах тварин: у 1,5; 1,2 і 1,7 раза в нормо-, гіпо- і гіперергічній групах відповідно, порівняно з показником відповідної групи тварин без лікування.

Висновки. Зміни активності фосфатаз свідчили про адаптаційну реакцію організму та ясен, зокрема про розвиток запального процесу в пародонті. Застосування протизапального гелю з неовітином у білих щурів при експериментальному гінгівіті мало більш виражений коригуючий вплив на цілий організм дослідних тварин.
100 років стоматологічному факультету Національного медичного університету імені О. О. Богомольця
Authors: Kaniura O. A. , Bidenko N. V. , Koval O. I. , Kuts P. V. , Melnyk A. O. , Filonenko V. V.
Published: December 2020

Резюме. У 2020 р. виповнюється 100 років від моменту заснування стоматологічного факультету Національного медичного університету імені О. О. Богомольця. Тому було видано наказ, згідно з яким одонтологічний інститут, створений у 1919 р. в Києві, приєднався до Інституту охорони здоров’я як окремий його факультет. Протягом свого існування факультет двічі (у 1931 і 1945 рр.) реорганізовувався в окремий стоматологічний інститут. У 1955 р. він остаточно трансформувався у стоматологічний факультет Київського медичного інституту імені академіка О. О. Богомольця. Сьогодні на факультеті працюють понад 150 викладачів на профільних кафедрах, з яких 16 докторів наук, 1 член-кореспондент НАМН України, 4 заслужені діячі науки і техніки України, 7 заслужених лікарів України, вчаться понад 1500 студентів-стоматологів з України та інших країн світу. 9 жовтня 2020 р. відбулися урочисті збори з нагоди 100-річчя стоматологічного факультету.
First-in-Human Study to Assess the Safety and Feasibility of the Bashir Endovascular Catheter for the Treatment of Acute Intermediate-Risk Pulmonary Embolism
Authors: Sista Akhilesh K. , Bhatheja Rohit , Rali Parth , Natarajan Kannan , Green Philip , Piazza Gregory , Comerota Anthony J. , Parikh Sahil A. , Lakhter Vladimir , Bashir Riyaz , Rosenfield Kenneth
Published: December 2020

Background:

The Bashir Endovascular Catheter (BEC) is a novel pharmaco-mechanical device designed to enhance thrombolysis by increasing the exposure of thrombus to endogenous and exogenous thrombolytics. The aim of this prospective, multicenter, single-arm study was to evaluate the feasibility and initial safety of the BEC in patients with acute intermediate-risk pulmonary embolism (PE).

Methods:

Patients with symptomatic PE and right ventricular to left ventricular diameter ratio ≥0.9 as documented by computer tomography angiography were eligible for enrollment. The primary safety end points were device related death or adverse events, and major bleeding within 72 hours after BEC directed therapy.

Results:

Nine patients were enrolled across 4 US sites. The total dose of r-tPA (recombinant tissue-type plasminogen activator) was 14 mgs in bilateral PE and 12 mgs in unilateral PE over 8 hours delivered via the expanded BEC. At 30-day follow-up, there were no deaths or device-related adverse events. At 48 hours post-BEC therapy, the right ventricular to left ventricular diameter ratio decreased from 1.52±0.26 to 0.97±0.06 (
P
=0.0009 [95% CI, 0.33–0.82]; 37.0% reduction). Thrombus burden as measured by the Modified Miller Index decreased from 25.4±5.3 to 16.0±4.0 (
P
=0.0005; [95% CI, 5.5–13.4]; 37.1% reduction).

Conclusions:

In this early feasibility study of the BEC for intermediate-risk PE, there were no deaths or device-related adverse events and a significant reduction in right ventricular to left ventricular diameter ratio and thrombus burden.

Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT03927508.
L’apport du Fonds François Abou Salem à la connaissance des débuts de la pratique théâtrale palestinienne dans les années 1970
Authors: Nakhlé-Cerruti Najla
Published: December 2020

Cet article propose d’étudier la période de l’émergence de l’activité théâtrale en Palestine à partir du fonds d’archives François Abou Salem car il apporte un éclairage particulier sur plusieurs processus en cours à ce moment : processus historique de l’émergence de la pratique et sa pérennisation, processus de création théâtrale et professionnalisation du mouvement.

Le fonds François Abou Salem se trouve au Théâtre National Palestinien/El-Hakawati à Jérusalem. Il a été constitué par François Gaspar, dit Abou Salem (1951-2011), homme de théâtre français établi à Jérusalem. Tout au long de sa carrière artistique, du début des années 1970 à sa mort en 2011, il a conservé ses propres archives. De la même manière que les archives du spectacle vivant, ce fonds s’est construit sur un paradoxe entre la dimension éphémère de la pratique qui s’oppose au caractère permanent et définitif de l’archive. Le fonds regroupe des matériaux de nature et de périodes différentes depuis l’émergence du mouvement théâtral palestinien, à la fondation de la première troupe de théâtre professionnelle (1977), puis à celle du premier théâtre palestinien en tant que lieu (1984), aux premières tournées à l’étranger (années 1980), et enfin à l’installation de la pratique théâtrale dans le paysage culturel, à Jérusalem et dans les Territoires palestiniens.
Is the Testament of Qahat Part of the Visions of Amram? Material and Literary Considerations of 4Q542 and 4Q547
Authors: Machiela Daniel
Published: December 2020

The contents of 4Q542 and 4Q547 have been treated in previous scholarship as representing two, independent Jewish literary compositions dating to the Hellenistic period, the Testament of Qahat and the Visions of Amram. However, paleographic, scribal, and other manuscript features strongly suggest that 4Q542 and 4Q547 are, in fact, parts of one and the same scroll. Consequently, in this article I reconsider the relationship of the contents of 4Q542/547. It may be that two independent works were copied on the same scroll, as we find elsewhere among the Qumran manuscripts (e.g., 4Q203–204). Another possibility is that what scholars have considered to be an independent composition in the Testament of Qahat is actually a sub-section of the Visions of Amram. The latter option gains strong support from a contextual assessment of other Aramaic writings found among the Dead Sea Scrolls, especially the Isaac section of the Aramaic Levi Document.
Harmonizing Binaries: Hypatia’s Synesius
Authors: Markus Donka
Published: December 2020

Hypatia and Synesius lived in a highly divisive time with religious extremism on the rise and the meaning and role of Classical cultural fixtures like paideia, philosophia and manteia being questioned and redefined. I examine Synesius’ Letters, Dion, and De Insomniis to tease out the universalizing and harmonizing tendencies between pagan and Christian, theoria and paideia, philosophia and manteia that Synesius’ writings, life and career embody. I look at Synesius’ synthesis of Iamblichean and Plotinian tendencies, a binary found in modern scholarship, to show that theurgy was likely part of Hypatia’s teaching within a well-rounded curriculum that included classical paideia and philosophical theoria. Synesius advocates for the importance of paideia, including rhetoric and philosophia as aids in the step-by-step approach to the spiritual ascent, while also acknowledging the value and universal accessibility of theoria reached by desert monks and the dream-divination (oneiromanteia) that everyone can experience in sleep. Paideia makes the fall from the heights of theoria more pleasant, while philosophia (which in Synesius’ mind included theurgy) is essential for purifying the pneuma and making it receptive to divinely inspired dreams. I propose that it was in Hypatia’s school that Synesius internalized a quote (from a lost work of Aristotle) that reconciles the two approaches (curated and amateur) to the ascent. While society at large was obsessed with ever widening opposites and binaries, Hypatia’s Synesius both overtly and covertly emphasized harmonization and unity that are at the heart of philosophia.
Corybas boholensis (Orchidaceae): A New Jewel Orchid Species from Bohol Island, Central Visayas, Philippines

Authors: TANDANG DANILO N. , REYES TOMAS JR. , BUSTAMANTE RENE ALFRED ANTON , CALLADO JOHN REY C. , TADIOSA EDWIN R. , AGOO ESPERANZA MARIBEL , LYON STEPHANIE P.
Published: December 2020

A new, critically endangered jewel orchid species, Corybas boholensis, is described and illustrated from forest over limestone on Bohol Island, Philippines. This diminutive species, belonging to the C. pictus complex, is distinct in having a deep red flower and a truncate, warty dorsal sepal with 9–11 veins at its widest point near the apex. This is the fifth species of Corybas recorded for the Philippines.
Termitomyces acriumbonatus sp. nov. (Lyophyllaceae, Agaricales) from Pakistan

Authors: USMAN MUHAMMAD , KHALID ABDUL NASIR
Published: December 2020

Four Termitomyces samples were collected in fungal surveys during 2016–2017 at Pabbi Forest Park, Punjab, Pakistan. Detailed morphological examination showed the four collections represent a new species. The phylogenetic analyses of Internal Transcribed Spacer (ITS) and Larger Sub-Unit (LSU) genes also supported the morphology to establish the new species which we describe and illustrate in this paper. The new species, Termitomyces acriumbonatus, is characterized by a small pileus 15–30 mm diam., with pointed grayish brown perforatium, cylindrical smooth stipe, and ellipsoid, 6.1−8.7 × 4.5–6.5 μm sized basidiospores.
Design and Implementation of Human-Computer Interaction Systems Based on Transfer Support Vector Machine and EEG Signal for Depression Patients’ Emotion Recognition
Authors: Chen Xiang , Xu Lijun , Cao Ming , Zhang Tinghua , Shang Zhongan , Zhang Linghao
Published: December 2020

At present, the demand for intelligentization of human-computer interaction systems (HCIS) has become increasingly prominent. Being able to recognize the emotions of users of interactive systems is a distinguishing feature of intelligent interactive systems. The intelligent HCIS can
analyze the emotional changes of patients with depression, complete the interaction with the patients in a more appropriate manner, and the recognition results can assist family members or medical personnel to make response measures based on the patient’s emotional changes. Based on
this background, this paper proposes a sentiment recognition method based on transfer support vector machines (TSVM) and EEG signals. The ER (ER) results based on this method are applied to HCIS. Such a HCIS is mainly used for the interaction of patients with depression. When a new field related
to a certain field appears, if the new field data is relabeled, the sample is expensive, and it is very wasteful to discard all the old field data. The main innovation of this research is that the introduced classification model is TSVM. TSVM is a transfer learning strategy based on SVM. Transfer
learning aims to solve related but different target domain problems by using a large amount of labeled source domain data. Therefore, the transfer support vector machine based on the transfer mechanism can use the small labeled data of the target domain and a large amount of old data in the
related domain to build a high-quality classification model for the target domain, which can effectively improve the accuracy of classification. Comparing the classification results with other classification models, it can be concluded that TSVM can effectively improve the accuracy of ER in
patients with depression. The HCIS based on the classification model has higher accuracy and better stability.
Analysis and Evaluation of Ultrasound Imaging Features and Pathological Results of Ovarian Cancer
Authors: Zhang Yuqing , Li Yan , Wu Mei , Zhang Feixue , Shao Guangrui , Wang Qing
Published: December 2020

To compare and analyze the relationship between the characteristics of ultrasound images of ovarian cancer and the results of postoperative pathological examination. A retrospective analysis of 206 patients with suspected ovarian cancer confirmed by surgical pathology was taken as the
research object. The location, size, morphology, partition and wall nodules, cystic solidity, and signal characteristics of the tumor were observed and compared with the results of postoperative pathological examination evaluation and analysis to improve the early clinical diagnosis of ovarian
cancer patients. By regression analysis of the histological examination of patients with ovarian tumors of different ages and the proportion of cox postoperative recurrence risk regression models, 154 of 206 ovarian tumor patients were ovarian cancer. There were significant differences in
pathological types, lesion locations, maximum diameter lengths, and internal echo in patients with ovarian malignant tumors at different ages (p < 0.05). Ultrasound of ovarian cancer shows that the tumor has large tumor body, strong echo, cyst wall has protrusions, and peripheral
and internal blood flow that is mainly high-speed and low-resistance. The sensitivity, specificity, and accuracy of ultrasound for ovarian cancer diagnosis are 84.38%, 66.67%, 81.01%. The accuracy, specificity, and sensitivity of early diagnosis of clinical ovarian cancer patients by ultrasound
imaging features provide sufficient imaging evidence to further promote the clinical judgment of benign and malignant tumors, which is beneficial to doctors’ clinical treatment of ovarian cancer patients. The early diagnosis and the higher clinical value were shown.
Dual-Energy Computed Tomography Virtual Noncalcium Imaging for the Detection of Acute Bone Marrow Edema in Vertebrae: Qualitative and Quantitative Analysis
Authors: Gu Lingjing , Liang Jianchao , Zhan Yingying , Pan Jielin , Zhang Yi , Cai Wenli , Hong Guobin
Published: December 2020

Purpose: To evaluate the feasibility of dual-energy computed tomography (DECT) virtual noncalcium (VNCa) images for detecting vertebral bone marrow edema (BME), both in qualitative and quantitative analyses. Materials and Methods: Nineteen cases with acute spinal trauma
were enrolled. DECT and MR Imaging were performed over an interval of 0–3 days within 3 weeks of injury. Both gray-scale and color-coded VNCa images were evaluated in an independent and blind manner using a three-scale grading system (2 = distinct BME, 1 = suspicious BME, and 0 = no
edema) by two radiologists. CT value of bone marrow were measured for each region and subjected to receiver operating characteristic (ROC) curve analysis for diagnosis of BME on VNCa images from DECT. Subsequently, as a standard of reference, MR imaging was evaluated by a third radiologist
for the presence of traumatic BME. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the detection of BME using VNCa images were evaluated. Kappa analysis and one-way ANOVA were performed to evaluate the consistency and variance of
VNCa images in the BME. Results: For two observers, the sensitivity of VNCa images for detecting BME (grade 2) were 97.8% and 96.7%, with the specificity 76% and 72%, the PPV 93.8% and 92.7%, the NPV 90.5% and 85.7%, respectively. And the sensitivity for detecting BME (grade 1–2)
were 94.3% and 94.3%, with the specificity 96.7% and 93.3%, the PPV 98.8% and 97.6%, the NPV 85.3% and 84.8%, respectively. The consistency test between the two observers showed that Kappa value was 0.650 (P < 0.001). The VNCa images had higher CT value in the positive regions
than in the negative regions (P < 0.05). Statistically significant differences in the CT value were identified in different regions with the three-scale grading system (thoracic levels: F = 136.690, P < 0.001; lumbar levels: F = 92.689, P < 0.001).
Conclusions: Acute traumatic BME in the vertebrae can be detected on VNCa images in both qualitative and quantitative analyses. DECT VNCa images are expected to serve as an additional method for the evaluation of BME.
Imaging Method for Osteosarcoma Diagnosis and Clinical Staging Information Optimization
Authors: Jia Huijuan , Zhao Xiuqin , Qin Lei , Cai Xiansheng
Published: December 2020

In order to better assist clinicians in the diagnosis and treatment of osteosarcoma, and our understanding of the advantages and disadvantages of different examination techniques of DR, CT and MRI, this article collects the pathological diagnosis of the PACS Medical system of Liaocheng
People’s Hospital 2015 to 2018. 130 patients with osteosarcoma and imaging examination data, retrospectively analyzed the diagnostic and clinical staging information contained in DR, CT and MRI examination data of osteosarcoma patients, and detected the diagnosis and clinical staging
information of osteosarcoma by comparing various examination methods ability to obtain the optimal imaging examination method that can provide complete diagnosis and clinical staging information of osteosarcoma, and is recommended as a routine clinical examination program. Finally, we conclude
that: DR, CT, and MRI examinations have no significant differences in the detection capacity of osteosarcoma bone destruction, periosteal response, and periosteal triangle; MRI has less ability to detect tumor bone than DR and CT; DR has soft tissue. The ability to detect masses is inferior
to CT and MRI. Among the single DR, CT or MRI examinations, CT examinations have the best comprehensive detection ability for all imaging diagnostic signs of osteosarcoma. MR examination has the best comprehensive display of clinical staging information such as infiltration range and infiltration
boundary of osteosarcoma. Combined DR, CT, and MRI examinations are optimized imaging procedures that provide complete osteosarcoma diagnosis and clinical staging information.
Epidemiology of Cyber Dating Abuse Victimization in Adolescence and Its Relationship With Health-Related Quality of Life: A Longitudinal Study
Authors: Ortega-Barón Jéssica , Montiel Irene , Machimbarrena Juan Manuel , Fernández-González Liria , Calvete Esther , González-Cabrera Joaquín
Published: December 2020

There is currently no evidence of the relationship between cyber dating abuse (CDA) and health-related quality of life (HRQoL), especially from a longitudinal perspective. The objectives were: a) to analyze the point and period prevalence, incidence, and score changes over time of victimization by CDA; b) to compare HRQoL in the different categories of victims of CDA (nonvictims, new, ceased, intermittent, and stable victims). A three-wave longitudinal study was carried out over 13 months. The final sample was composed of adolescents who had a partner in the 6 months before the measurements: 341(W1), 357(W2), and 416(W3). The prevalence of CDA was 31.1% (W1), 32.8% (W2), and 18.1% (W3). The girls had higher prevalence in victimization by control than the boys in all waves. The period prevalence was 23% (20% for control, 15% for direct aggression) and the cumulative incidence was 15%. Stable victims had the lowest HRQoL scores.
Characteristic model-based adaptive control for cryogenic wind tunnels
Authors: Yu Chenhui , Liao Fei , Ji Haibo , Wu Wenhua
Published: December 2020

With the increasing requirement of Reynolds number simulation in wind tunnel tests, the cryogenic wind tunnel is considered as a feasible method to realize high Reynolds number. Characteristic model-based adaptive controller design method is introduced to flow field control problem of the cryogenic wind tunnel. A class of nonlinear multi-input multi-output (MIMO) system is given for theoretical research that is related to flow field control of the cryogenic wind tunnel. The characteristic model in the form of second-order time-varying difference equations is provided to represent the system. A characteristic model-based adaptive controller is also designed correspondingly. The stability analysis of the closed loop system composed of the characteristic model or the exact discrete-time model and the proposed controller is investigated respectively. Numerical simulation is presented to illustrate the effectiveness of this control method. The modeling and control problem based on characteristic model method for a class of MIMO system are studied and first applied to the cryogenic wind tunnel control field.
Gravitational Analysis in Regional Science and Spatial Economics: A Vector Gradient Approach to Trade
Authors: Nijkamp Peter , Ratajczak Waldemar
Published: December 2020

For decades, gravitational analysis has been a key instrument in analyzing spatial flows. Time and again, it has prompted new and challenging research questions. This paper provides a concise overview of the foundation, the conceptualization and empirical relevance of gravitational principles in regional science and spatial economics. Attention is also given to general “social physics” interpretations of gravity in spatial interaction models and to the impact of intangible distance frictions. The main emphasis in the study is placed on the significance of spatial impedance functions and gravity potential analysis. In particular, the paper focuses on cross-border trade and has three main goals: (i) to address the robustness of distance friction parameters related to trade borders, employing, inter alia, quantitative results from meta-analyses on trade models in spatial economics; (ii) to present a promising methodology based on gravity potential and the related gravitational gradient models that include directional intensities of flows; (iii) to test the validity of the latter approach on the basis of a vector gradient analysis of export patterns of the Netherlands. The paper argues that—despite the space-reducing impact of the modern digital technologies—gravitational principles still have an uncontested relevance in an analysis of spatial flows in regional science.
Interacting with the ordinary people: How populist messages and styles communicated by politicians trigger users’ behaviour on social media in a comparative context
Authors: Hameleers Michael , Schmuck Desirée , Bos Lieke , Ecklebe Sarah
Published: December 2020

Populist politicians’ social media activity has often been associated with their electoral success. Yet, research on the driving forces of engagement on social media is scarce. Are populist politicians triggering more interaction than mainstream politicians, or is it rather the populist ideology they convey? To disentangle these different factors, we conducted a comparative content analysis of Twitter and Facebook communication of 13 leading candidates in Austria and the Netherlands during an election campaign. Findings show that it is rather styles conductive to populism (i.e. emotionality, first-person references) than the actual content of populist communication that trigger online behaviour. Importantly, irrespective of the content they convey, right-wing populist politicians are more successful in spreading their message via social media than mainstream politicians. These findings have important implications for our understanding of the role of online communication for populist politicians’ success in spreading their viewpoints across networked societies.
Deportations and development: Responding to El Salvador’s new migration crisis
Authors: Theodore Nik
Published: December 2020

For decades El Salvador has been reliant on migration, mainly to the US, to provide remittances and an outlet for widespread underemployment. The deportation of tens of thousands of migrants annually by the United States, however, threatens to exacerbate problems of joblessness, poverty, and informality in local economies, calling into question the suitability of prevailing economic development strategies. This study proposes an alternative approach—labor force-based development—that was initially proposed to assist US cities confronting widespread job losses following deindustrialization. Through a survey of 198 Salvadorans who were apprehended by US immigration authorities and deported, this article documents deportees’ employment experiences in El Salvador and the US, tenure in their primary occupation, education and training obtained, and the localities to which they will return. It also provides recommendations for improving the employment outcomes of deportees. Given that a substantial proportion of deportees have worked in the construction industry, opportunities exist for designing workforce development programs that meet the needs of jobseekers as well as local communities facing housing shortages.
Liposomal doxorubicin-related palmar–plantar erythrodysesthesia (hand–foot syndrome): a case report
Authors: Ni Chenxu , Fang Juemin , Qian Hong , Xu Qing , Shen Fuming
Published: December 2020

Hand–foot syndrome (HFS) is a skin toxicity that occurs in areas of compressed skin. HFS manifests mainly in insensitive palms and the soles of the feet or in erythematous areas on the extremities caused by chemotherapy, which may be related to the dosage. This paper reports a case of HFS caused by liposomal doxorubicin. A 64-year-old Asian woman presented with severe erythema, ulceration, pruritus, and edema-related pain in her back, hands, and feet after receiving four cycles of liposomal doxorubicin. Clinicians and a pharmacist analyzed and evaluated the patient’s adverse reactions. After symptomatic treatment and patient education, her HFS symptoms were significantly relieved. The purpose of this study was to raise clinical awareness regarding adverse events following liposomal doxorubicin injection, and to provide new ideas for the clinical treatment of these adverse events.
Adverse Childhood Experiences and Physical and Mental Health of Adults: Assessing the Mediating Role of Cumulative Life Course Poverty
Authors: Huang Ying , Liu Han , Masum Muntasir
Published: December 2020

Objectives:

Research has linked adverse childhood experiences (ACEs) to a host of negative health outcomes in adulthood. However, most existing studies focused on traumatic ACEs and used samples collected from a specific geographic unit (e.g., region, city, or state). This study examines the association between non-traumatic ACEs and health outcomes (i.e., self-rated health and psychological well-being) in adulthood, and assesses the extent to which the cumulative life course poverty accounts for these associations between ACEs and health.

Data Source:

Public and de-identified data from Panel Study of Income Dynamics (PSID) (1968-2013) and its Childhood Retrospective Circumstances Study (CRCS) (2014) ( N = 7,126) were used. Episode and severity of childhood adversities of respondents were determined by using comprehensive retrospective circumstance measures.

Methods:

Multivariate regression models were used to analyze the associations between ACEs and adult health. Mediation analysis was employed to assess the extent to which the associations were explained by cumulative life course poverty. Data analysis was carried out in 2019 using STATA 15.

Results:

We found that episode and severity of ACEs were associated with increased risk of poor health and psychological distress. Compared to individuals with no ACEs, one unit increase in the ACE index is associated with 8 and 18 percent increase in the risk of poor health and psychological distress, respectively. A small proportion (4%) of the impact of early adversities on health is attributable to the proportion of adult lifetime spent in poverty.

Conclusions:

Non-traumatic ACEs are associated with increased risk for poor health and psychological distress. Life course cumulative experience in poverty accounts for a small portion of the associations. Providing support to prevent ACEs may have long-term health benefits.
Marketisation of Academia and Authoritarian Governments: The Cases of Hungary and Turkey in Critical Perspective
Authors: Dönmez Pinar E. , Duman Anil
Published: December 2020

This article analyses the recent political repression of academia in Hungary and Turkey within the critical scholarship on globalisation and neoliberalisation of higher education. We introduce and challenge the hegemonic definitions of academic freedom that sit comfortably with the capitalist logic as well as repressive governing forms and assess the recent attacks on university communities with emphasis on both academic labour and freedom. Adopting a case study approach, we investigate how economic and political forms of repression accompany and reinforce one another within the specificities of both country contexts. We delineate the underlying structural and historical dynamics as well as emergence and evolution of methods of struggle and resistance employed by diverse university communities in their shared and divergent characteristics. Our conclusions include critical reflections on the broader implications of higher education restructuring, authoritarian interventions, and the future of systemic-level resistance.
Buxus sempervirens and Laurus nobilis leaves from an archaeological site at 7300 cal BP (La Draga, Spain) provide a better understanding of past vegetation and human activities
Authors: Castells Eva , Araya-Piqué Valentina , Behncké Ada , Piqué Raquel
Published: December 2020

Leaves are valuable, but very rare, remains in archaeological contexts, as they can provide precise information on the landscape vegetation composition, the past climatic conditions and the use of plant resources in a settlement. La Draga (Spain) is an early Neolithic site partially waterlogged, which has allowed the preservation of organic material. During the excavation of the oldest level (7300–7000 cal BP), we recovered 29 leaf samples in an optimal state of preservation. Here we explore the potential of these leaves as indicators both of the use of vegetation at the settlement and of past climatic conditions. Firstly, we determined the species identity by comparing the leaf morphological and microanatomical traits with those of contemporary individuals. Secondly, we analyzed the leaf stomatal patterning (stomatal density, index, and size) as proxies of paleoclimate during the Neolithic, when lower atmospheric CO2 and wetter conditions are documented. The leaves of La Draga were identified as Laurus nobilis and Buxus sempervirens, two evergreen species well documented at the site from other archaeobotanical records, such as charcoal and wooden implements. We found no differences in stomatal traits between the archaeological and the contemporary leaves of L. nobilis and B. sempervirens, which shows the limitation of stomatal frequency as proxies for CO2. The presence of these species at the site provides good complementary data for past woodland vegetation composition and the production of wood implements. The wide distribution of L. nobilis leaves across the site suggests that this taxon was present in the riparian forest at the site surroundings. In contrast, leaves of B. sempervirens were grouped together, which might indicate that they belonged to the same branch, probably transported as raw material from nearby forests to the settlement. This study illustrates the value of archaeological leaves to provide a better understanding on the past vegetation and human activities.
A group sequential design and sample size estimation for an immunotherapy trial with a delayed treatment effect
Authors: Li Bosheng , Su Liwen , Gao Jun , Jiang Liyun , Yan Fangrong
Published: December 2020

A delayed treatment effect is often observed in the confirmatory trials for immunotherapies and is reflected by a delayed separation of the survival curves of the immunotherapy groups versus the control groups. This phenomenon makes the design based on the log-rank test not applicable because this design would violate the proportional hazard assumption and cause loss of power. Thus, we propose a group sequential design allowing early termination on the basis of efficacy based on a more powerful piecewise weighted log-rank test for an immunotherapy trial with a delayed treatment effect. We present an approach on the group sequential monitoring, in which the information time is defined based on the number of events occurring after the delay time. Furthermore, we developed a one-dimensional search algorithm to determine the required maximum sample size for the proposed design, which uses an analytical estimation obtained by the inflation factor as an initial value and an empirical power function calculated by a simulation-based procedure as an objective function. In the simulation, we tested the unstable accuracy of the analytical estimation, the consistent accuracy of the maximum sample size determined by the search algorithm and the advantages of the proposed design on saving sample size.
Searching for Success—Entrepreneurs’ Responses to Crowdfunding Failure
Authors: Piening Erk P. , Thies Ferdinand , Wessel Michael , Benlian Alexander
Published: December 2020

In this study, we seek to provide new insights into the process of problemistic search by examining entrepreneurs’ behavioral responses to failures. Using a comprehensive dataset of over 65,000 crowdfunding projects, we specifically explore how negative performance feedback influences entrepreneurs’ search distance. Our results demonstrate that the severity and persistence of failure have a U-shaped and inverted U-shaped relationship with search distance, respectively. Moreover, greater temporal distance between an entrepreneur’s failure experience and a subsequent crowdfunding project is not only associated with increases in search distance, but also attenuates the curvilinear main effects.
Adaptation and Validation of the LGBTCI to the Spanish LGBT Working Population
Authors: Rivero-Díaz María Luz , Agulló-Tomás Esteban , Llosa Jose Antonio
Published: December 2020

The Lesbian, Gay, Bisexual and Transgendered Climate Inventory (LGBTCI) is the only instrument that, from a holistic viewpoint, makes it possible to evaluate the workplace climate of support and/or hostility for LGBT workers. Recently, however its factor structure has been questioned. In addition, there is not a validated version in the Spanish-speaking countries. This study has the aim of adapting and validating the LGBTCI to the Spanish context and to investigate their factor structure through more accurate procedures. 587 LGBT Spanish nationality workers completed the LGBTCI and other scales. Its internal structure was checked by exploratory and confirmatory factor analysis and by exploratory structural equation modeling. The final scale of 15 items is divided into two-correlated factors (Support and Non-Hostility). Validity was supported by showing that both sub-scales were related negatively to job insecurity and turnover intentions and positively to work satisfaction, life satisfaction, P-O fit, P-J fit. This version has suitable psychometric properties for application and will allow an advance in research on the inclusion of LGBT workers in the Spanish-speaking context.
Evaluation of Coagulation, Fibrinolysis and Endothelial Biomarkers in Cirrhotic Patients With or Without Portal Venous Thrombosis
Authors: Ren Wenhua , Zhang Jing , Chen Yuying , Wen Meng , Su Yu , Zhao Yujing , Lu Shan , Wu Jun
Published: December 2020

To evaluate variations in coagulation, fibrinolysis and endothelial marker expression in cirrhotic patients and to explore their clinical value and predictive performance in cirrhotic patients with or without portal vein thrombosis (PVT), we performed a case-control study with 175 cirrhotic patients and 50 healthy individuals. 99 patients had PVT and another 76 patients did not. All participants were evaluated for plasma levels of conventional hemostatic markers. Thrombin-antithrombin complex (TAT), plasmin-α2-plasmin inhibitor complex (PIC), thrombomodulin (TM), tissue plasminogen activator inhibitor complex (t-PAIC), von Willebrand factor antigen (vWF: Ag) and coagulation factor Ⅷ (FⅧ: c) were also assessed and the ratio of TAT/t-PAIC was calculated. We analyzed differences in these biomarkers among the three groups and constructed receiver operating characteristic (ROC) curves. Patients with PVT exhibited significantly higher TAT and TAT/t-PAIC than cirrhotic patients without PVT (both P < 0.001). Areas under the curve (AUC) of ROC analyses for TAT and TAT/t-PAIC were 0.68 and 0.66, the cut-off levels were 1.55 ng/ml and 0.46, with sensitivities and specificities of 78.79% and 51.32% regarding TAT, 39.8% and 90.79% regarding TAT/t-PAIC. Levels of FⅧ: c and vWF: Ag in patients with PVT were significantly lower than those without PVT (p = 0.026 and p = 0.027, respectively). The AUCROC, cut-off level, sensitivity and specificity of FⅧ: c were 0.64, 111.1%, 66.67% and 60%, respectively. For vWF: Ag they were 0.61, 429%, 89.66% and 38.71%, respectively. Cirrhotic patients have disorders of coagulation, fibrinolysis and the endothelial system. TAT, TAT/t-PAIC, FⅧ: c and vWF: Ag can be used as potential biomarkers for predicting PVT in cirrhotic patients.
Mothering after Moomba: Labelling, secondary stigma and maternal efficacy in the post-settlement context
Authors: Maher Sara , Blaustein Jarrett , Benier Kathryn , Chitambo Joseph , Johns Diana
Published: December 2020

Parenting can impact young people’s justice system involvement but there is a scarcity of research that examines how parenting practices, specifically mothering, are influenced by labelling processes. Accordingly, this article considers how the labelling of young people from forced migration backgrounds as criminals impacted mothering and maternal efficacy during a ‘law and order crisis’ in Melbourne, Australia. Drawing on interviews and focus groups with mothers and young people of South Sudanese heritage, we illustrate how this hostile social climate generated secondary stigma, and amplified anxieties and concerns about inclusivity and belonging. The research advances our theoretical understanding of parental control and parental efficacy in the post-settlement context by bringing the gendered experiences of mothers as providers of supervision and support into focus. It suggests labelling may undermine maternal efficacy and exacerbate intercultural and intergenerational tensions, but that community involvement may support parents and mitigate the risk of deviance amplification.