bluuebunny/crossref_metadata_2025 huggingface dataset:
Philadelphia Chromosome Positive Chronic Myelogenous Leukemia Blastic
Crisis in a Patient with Unusual Primary Myelofibrosis Characteristics; A
Case Report
Authors: Razmara Lak Elahe , Sharifzadeh Sedigheh , Ramzi Mani , Mokhtari Maral , Asadpouri Reza , Abedi Elham , Tamaddon Gholamhossein
Published: June 2023

Introduction:

Myeloproliferative neoplasms (MPNs) are divided into BCR-ABL positive
Chronic myeloid leukemia (CML) and BCR-ABL negative MPNs including Polycythemia
vera (PV), Essential Thrombocythemia (ET) and Primary myelofibrosis (PMF). Evaluation of the
Philadelphia chromosome in MPNs is a diagnostic requirement for classic CML.

Case Report:

In 2020, a 37-year-old woman with negative cytogenetic testing for Janus kinase2
(JAK2), Calreticulin (CALR), myeloproliferative leukemia virus oncogene (MPL), and positive
for BCR-ABL1 mutation with reticular fibrosis in bone marrow was diagnosed as CML. Some
years ago, the patient had been diagnosed with PMF with evidence of histiocytic necrotizing lymphadenitis
or Kikuchi-Fujimoto disease (KFD). The BCR-ABL fusion gene was initially evaluated
which was negative. Then, Cutaneous squamous cell carcinoma (cSCC) was confirmed by Dermatopathologist
with palpable splenomegaly and high white blood cell (WBC) count with basophilia.
Finally, BCR-ABL was detected positive by the fluorescence in situ hybridization (FISH)
and quantitative real-time polymerase chain reaction (qRT-PCR). In fact, the co-occurrence of
PMF with CML was identified.

Conclusion:

This case study highlighted the importance of some cytogenetic methods in the detection
and classification of MPNs. It is recommended that physicians pay more attention to it and be
aware of the planning treatment.
Review of Anti-Counterfeit Solutions in Blockchain
Authors: Bhatia H. , Zalte S. , Chatterjee I. , Mantri D.
Published: June 2023

Blockchain technology offers a data format that has built-in security. It is
built on cryptography, decentralization, and consensus concepts to ensure transaction
confidence. Decentralization is enabled by blockchain technology, which allows
members to participate in a dispersed network. No single user can alter the transaction,
as all transactions are transparent and visible to all other users on the network.
However, there are some significant security differences between blockchain and other
systems. Nowadays, there are so many potential attacks found on the blockchain. The
contribution of this chapter would be to match the effective defence taken by
blockchain technology or a patch for related vulnerabilities offered by researchers to
reduce the impact of these attacks. To keep the network secure and resilient, an
overview of these security solutions for various vulnerabilities and attacks helps to
reduce the attack surface in the blockchain
Blockchain Based Access Control Systems
Authors: Agrawal R. , Gupta N.
Published: June 2023

While accessing data through the Internet of Things (IoT), privacy and
safety are the most important features. IoT developers have a challenging job of
securing and protecting the data of the users during the development process due to the
complicated nature of decentralisation and heterogeneity of the environment present in
IoT. There are several access control models for the IoT available in the literature
which rely on centralized architecture and raises security concerns because IoT devices
can spontaneously and dynamically interact with one another. The need for secure and
distributed access control architecture to overcome the single point of failure problem
of a centralized entity becomes a big challenge when coupled with scalability and
lightweight features. It is possible to achieve this through the use of Blockchain
technology, which has recently been used to provide access control services. IoT
device management would be used to manage distribution, heterogeneity, scalability,
the ability to tolerate failure, security and privacy aspects of IoT devices at scale in the
near future as it is useful.
Associations Between Personality Traits and Energy Balance Behaviors in Emerging Adulthood: Cross-Sectional Study
Authors: Champion Katrina E , Chapman Cath , Sunderland Matthew , Slade Tim , Barrett Emma , Kelly Erin , Stapinski Lexine , Gardner Lauren A , Teesson Maree , Newton Nicola C
Published: June 2023

Background

Internalizing and externalizing personality traits are robust risk factors for substance use and mental health, and personality-targeted interventions are effective in preventing substance use and mental health problems in youth. However, there is limited evidence for how personality relates to other lifestyle risk factors, such as energy balance–related behaviors, and how this might inform prevention efforts.

Objective

This study aimed to examine concurrent cross-sectional associations between personality traits (ie, hopelessness, anxiety sensitivity, impulsivity, and sensation seeking) and sleep, diet, physical activity (PA), and sedentary behaviors (SB), 4 of the leading risk factors for chronic disease, among emerging adults.

Methods

Data were drawn from a cohort of young Australians who completed a web-based, self-report survey in 2019 during early adulthood. A series of Poisson and logistic regressions were conducted to examine the concurrent associations between the risk behaviors (sleep, diet, PA, and sitting and screen time) and personality traits (hopelessness, anxiety sensitivity, impulsivity, and sensation seeking) among emerging adults in Australia.

Results

A total of 978 participants (mean age 20.4, SD 0.5 years) completed the web-based survey. The results indicated that higher scores on hopelessness were associated with a greater daily screen (risk ratio [RR] 1.12, 95% CI 1.10-1.15) and sitting time (RR 1.05, 95% CI 1.0-1.08). Similarly, higher scores on anxiety sensitivity were associated with a greater screen (RR 1.04, 95% CI 1.02-1.07) and sitting time (RR 1.04, 95% CI 1.02-1.07). Higher impulsivity was associated with greater PA (RR 1.14, 95% CI 1.08-1.21) and screen time (RR 1.06, 95% CI 1.03-1.08). Finally, higher scores on sensation seeking were associated with greater PA (RR 1.08, 95% CI 1.02-1.14) and lower screen time (RR 0.96, 95% CI 0.94-0.99).

Conclusions

The results suggest that personality should be considered when designing preventive interventions for lifestyle risk behaviors, particularly in relation to SB, such as sitting and screen time.

Trial Registration

Australian New Zealand Clinical Trials Registry ACTRN12612000026820; https://tinyurl.com/ykwcxspr
Reliability of Medical Information Provided by ChatGPT: Assessment Against Clinical Guidelines and Patient Information Quality Instrument
Authors: Walker Harriet Louise , Ghani Shahi , Kuemmerli Christoph , Nebiker Christian Andreas , Müller Beat Peter , Raptis Dimitri Aristotle , Staubli Sebastian Manuel
Published: June 2023

Background

ChatGPT-4 is the latest release of a novel artificial intelligence (AI) chatbot able to answer freely formulated and complex questions. In the near future, ChatGPT could become the new standard for health care professionals and patients to access medical information. However, little is known about the quality of medical information provided by the AI.

Objective

We aimed to assess the reliability of medical information provided by ChatGPT.

Methods

Medical information provided by ChatGPT-4 on the 5 hepato-pancreatico-biliary (HPB) conditions with the highest global disease burden was measured with the Ensuring Quality Information for Patients (EQIP) tool. The EQIP tool is used to measure the quality of internet-available information and consists of 36 items that are divided into 3 subsections. In addition, 5 guideline recommendations per analyzed condition were rephrased as questions and input to ChatGPT, and agreement between the guidelines and the AI answer was measured by 2 authors independently. All queries were repeated 3 times to measure the internal consistency of ChatGPT.

Results

Five conditions were identified (gallstone disease, pancreatitis, liver cirrhosis, pancreatic cancer, and hepatocellular carcinoma). The median EQIP score across all conditions was 16 (IQR 14.5-18) for the total of 36 items. Divided by subsection, median scores for content, identification, and structure data were 10 (IQR 9.5-12.5), 1 (IQR 1-1), and 4 (IQR 4-5), respectively. Agreement between guideline recommendations and answers provided by ChatGPT was 60% (15/25). Interrater agreement as measured by the Fleiss κ was 0.78 (P<.001), indicating substantial agreement. Internal consistency of the answers provided by ChatGPT was 100%.

Conclusions

ChatGPT provides medical information of comparable quality to available static internet information. Although currently of limited quality, large language models could become the future standard for patients and health care professionals to gather medical information.
Algorithmic Case Identification of Depression in Inpatient Electronic Medical Records: Systematic Review (Preprint)
Authors: Grothman Allison , Ma William J. , Tickner Kendra G. , Slater-Kinghorn Oliver D. , Martin Elliot A. , Southern Danielle A. , Quan Hude
Published: June 2023

BACKGROUND

Electronic medical records (EMRs) contain large amounts of detailed clinical information. Using chart review to identify conditions within large quantities of EMRs can be time-consuming and inefficient. EMR-based phenotyping utilizing machine learning (ML) and natural language processing (NLP) algorithms is a continually developing area of study that holds potential for numerous mental health disorders.

OBJECTIVE

This review outlines and evaluates the current state of EMR-based case phenotyping for depression.

METHODS

A systematic review of EMR-based algorithms for phenotyping depression was completed. This research encompassed studies published from January 2000 to May 2023. The search involved three databases: Embase, MEDLINE, and APA PsycInfo. This was done using selected keywords that fall into three categories: terms connected with EMR, terms connected to case identification, and terms pertaining to depression. This document adheres to the Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Reviews (PRISMA) guidelines.

RESULTS

A total of 20 articles were assessed and summarized in the review. Most of these studies were undertaken in the United States, accounting for 75% (15/20). This was followed by the United Kingdom with 15% (3/20) and Spain with 10% (2/20). Both data-driven and clinical rule-based methodologies were identified. The development of EMR-based phenotypes and algorithms is indicative of the data accessibility permitted by each respective health system, leading to varying performance levels among different algorithms.

CONCLUSIONS

It is crucial to understand the commonalities and disparities in health systems, data gathering techniques, data release procedures, and current clinical routes for successful algorithm development strategies. There have been several propositions for strategies that aid in defining cases based on phenotype.
Exploring the Application Potential of the Large Language Model in Sociological Research: A Case Study of ChatGPT
Authors: Liu Ke
Published: June 2023

With the exponential growth of Big Data and Artificial Intelligence (AI), large Language models have emerged as powerful tools in sociological research. As an advanced large Language model, ChatGPT has the unique ability to generate natural language dialogues, opening up new avenues for sociological research. This paper employs ChatGPT as a case study to explore the application potential of large Language models in sociological research, including social network analysis, sentiment analysis, opinion mining and social public opinion monitoring. Additionally, we discuss the various challenges encountered by large Language models in sociological research, such as privacy, ethical, interpretability and credibility issues. Finally, some recommendations to overcome these challenges and prospective research directions are provided.
Una breve revisión histórica de la política social de México 1982-2004
Authors:   Instituto de Investigaciones Económicas, Delgado Martínez Irma
Published: June 2023

El concepto de política social encierra distintas dimensiones de análisis. Como área de conocimiento, hace referencia al conjunto de teorías que tratan de explicar qué necesidades se definen como sociales y con qué tipo y cantidad de recursos, también sociales, deben ser atendidas. Analiza, qué agentes sociales participan en la definición de tales necesidades y en la forma de gestionar los recursos.
A Systematic Study to Strengthen the Sub Grade of the Pavement by Stabilization of Expansive Soil with Molasses and Jute Fibre
Authors: Santhosh Karakavalasa Sai , Ramesh B.
Published: June 2023

Abstract: Expansive soils, commonly referred to as Black cotton soils (BC), possess undesirable engineering properties such as low bearing capacity and high compressibility. To address these challenges, various stabilizers have been used to enhance the strength of expansive soil, including jute fiber and molasses. This thesis focuses on investigating the effects of incorporating jute fiber as a stabilizer and molasses as an additive to improve the properties of expansive soil. The objectives of this study are to enhance the shear strength of expansive soil by blending jute fiber and molasses mixtures. Jute fibers of different lengths (1cm, 2cm, 3cm, and 4cm) and various percentages (0.5%, 1%, 1.5%, and 2%) are used as stabilizers. Molasses is employed as an additional stabilizer with varying percentages (5%, 8%, 12%, and 15%). Laboratory investigations reveal that the addition of 12% molasses and 1.5% jute fiber significantly reduces the liquid limit, plastic limit, and plasticity index of the expansive soil, while simultaneously increasing the maximum dry density and California Bearing Ratio (CBR). Furthermore, cyclic load test results demonstrate a 62% improvement in the load carrying capacity of the treated expansive soil subgrade flexible pavement compared to untreated expansive soil flexible pavement. Utilizing construction wastes like molasses offers an alternative to reduce road construction costs, especially in rural areas of developing countries. Additionally, jute fiber provides effective reinforcement for expansive soils. These findings highlight the potential of jute fiber and molasses as sustainable and cost-effective stabilizers for enhancing the performance of expansive soils in construction projects
Performance Of Accounting Teachers And Education Staff: The Role Of Cyberloafing And Work Stress
Authors: Malik Nazaruddin
Published: June 2023

This study aims to examine the effect of cyberloafing and work stress on the performance of accounting teachers and education staff. This type of research uses a quantitative approach. The number of samples used was 38 respondents. Sources of data in this study were obtained from distributing questionnaires (primary data). The collected data were analyzed using path analysis. The results of this study are that cyberloafing has a significant negative effect on the performance of accounting teachers and education staff. Work stress has a significant negative effect on the performance of accounting teachers and education staff. Work stress does not mediate the effect of cyberloafing on the performance of accounting teachers and education staff. This research has an impact on policies on human resources, especially accounting makers in completing their tasks.
The new mathematical model approaches in biodiesel optimization
Authors: ASLAN VOLKAN
Published: June 2023

Post-pandemic inflationist pressures, climate changes and extremes,
regional conflicts, and soaring food prices caused the food crisis to
increase rapidly worldwide. This global problem directs producers and
researchers to use oils used as feedstock in biodiesel production
effectively. In this context, it is important to assay the
transesterification parameters and conduct new optimization studies to
increase biodiesel yield. In this study, methyl ester was produced from
hemp oil by transesterification using sodium hydroxide (NaOH). Next,
classical optimization study was carried out to determine the effects of
catalyst amount, alcohol:oil molar ratio, reaction temperature, and
reaction time variables on biodiesel yield. Secondly, the cubic spline
mathematical model (CSMM) and polynomial regression mathematical model
(PRMM) was applied to the first data of this optimization. Among these
optimization methods, the utmost biodiesel yield registered was 96.115%
at hemp seed oil (HSO): methanol molar ratio of 5.59:1, catalyst
concentration of 0.531 wt%, reaction temperature of 42.5 °C, reaction
time of 62.1 min, and agitation intensity of 600 rpm at PRMM. Some vital
fuel properties obtained from HSO biodiesels as a result of three
optimizations satisfied the EN 14214 standard. The results illustrated
that the optimal yields from CSMM and PRMM are 0.765% and 1.065%
higher, respectively, according to the maximum efficiency obtained from
the classical optimization. The outcomes showed that CSMM and PRMM are
cost-effective, easy to handle and promising new approaches.
Site specific insertion of a transgene into the murine α-casein (CSN1S1) gene results in the predictable expression of a recombinant protein in milk
Authors: Knowles Christopher , Petrie Linda , Warren Claire , Lillico Simon , Carlisle Ailsa , Whitelaw Bruce , Kolb Andreas
Published: June 2023

Gene loci of highly expressed genes provide ideal sites for transgene
expression. Casein genes are highly expressed in mammals leading to the
synthesis of substantial amounts of casein proteins in milk. We have
assessed the α-casein (CSN1S1) gene as a site of transgene expression in
transgenic mice and a mammary gland cell line. A transgene encoding an
antibody light chain gene (A1L) was inserted into the α-casein gene
using sequential homologous and site-specific recombination. Expression
of the inserted transgene is directed by the α-casein promoter, is
responsive to lactogenic hormone activation, leads to the synthesis of a
chimeric α-casein/A1L transgene mRNA and secretion of the recombinant
A1L protein into milk. Transgene expression is highly consistent in all
transgenic lines, but much lower than that of the α-casein gene (4%).
Recombinant A1L protein accounted for 0.5% and 1.6% of total milk
protein in heterozygous and homozygous transgenic mice, respectively.
The absence of the α-casein protein in homozygous A1L transgenic mice
leads to a reduction of total milk protein and delayed growth of the
pups nursed by these mice. Overall, the data demonstrate that the
insertion of a transgene into a highly expressed endogenous gene is
insufficient to guarantee its abundant expression.
The Effects of Positive Behavior Support(PBS) on Problem Behaviors for a Young Child with Autism in an Inclusive Setting
Authors: Lim Da-Kyoung , Lee Byoung-In
Published: June 2023

The purpose of this study is to find out the effects of positive behavior support (PBS) in integrated classes on the behavior of autistic behavior disorder in young children. One 5-year old autistic behavior disorder child in the integrated class of public kindergarten in Gyeonggi-do was selected. The study was conducted multiple factors mediations based on functional assessment of the target child using "Multiple baseline design across behavior”. Mediations were conducted to provide positive action support including danger and distraction behaviors and intervention in background and prior events about rejection of food, arbitrations of alternative technology professors, follow-up results and long-term support for risk behavior. Mediation was performed after measuring the baseline, and maintenance data was collected 10 days after the end of arbitrations. Research has shown that positive behavior support in integrated classes has had a positive effect on maintaining a reduction in problem behavior after the termination of arbitration and reduction of problem behavior in autistic disorder children. This study is meaningful to demonstrate that positive behavior support in integrated class is an effective strategy for preventing and mediating problem behavior in autistic disorder children.
The Effects of Individualized Positive Behavior Support on Challenging and Alternative Behavior of a Middle School Student with Autism Spectrum Disorder in Special School
Authors: Lee Surnhee , Paik Eunhee , Park Gyeshin
Published: June 2023

The purpose of this study was to investigate the effects of an individualized positive behavior support on challenging behavior(self-injurious·aggressive behaviors and transition refusal behaviors) and alterative behavior(requesting and transition-related compliance behaviors) of a middle school student with autism spectrum disorder. The subject of this study was a student with autism spectrum disorder in 9th grade who was enrolled in a special school. The individualized positive behavior support was implemented utilizing multiple design across behaviors. The collected data were analyzed for interventional effects through visual analysis(the average and range, the trend of data using the split-middle line and percentage of non-overlapping data points; PND). The results of this study were as follows: First, individualized positive behavior support was effective reducing the self-injurious·aggressive behaviors and transition refusal behaviors of the target student. Second, the individualized positive behavior support was effective increasing the requesting and transition-related compliance behaviors. The results of the study were discussed in terms of intervention based on functional behavior assessment, multi-element intervention strategies, the use of evidence-based practice considering the characteristics of autistic disorders, and positive behavior support based on a collaborative team approach.
A Review of Research Trends and Program Characteristics Implementing Class-Wide Function-related Intervention Team (CW-FIT)
Authors: Lee Sora , Lee Youngsun
Published: June 2023

This study aimed to analyze the trends and the program characteristics of international research applied to the class-wide function-related intervention team (CW-FIT). In total, 16 papers were selected according to the inclusion and exclusion criteria through the search of articles published in English from 2010 to 2020. Research trends were examined through the analysis of general characteristics(publication year, research subject, research method) of the study, and the characteristics of the program by support level (primary support, secondary support) were analyzed in detail. The results of the study are as follows. First, in foreign studies, most of the CW-FIT programs were conducted in general elementary school classes, and in a number of studies, class task performance behavior was measured through the implementation of primary support using frequency recording method and time sampling method through reversal design. Second, positive results were showed in the student's task performance behavior and disturbance behavior, class task performance behavior, and teacher's praise, which represent behavioral problems through social skills teaching and group reinforcement, which are the main components of the CW-FIT program. Third, it was shown that the primary and secondary support was more effective than the primary support. Based on the results of the study, the direction of further research and plans for application in the educational field were discussed.
Comparing the Performances of Youth with Intellectual Disability and Autism Spectrum Disorder with a Distributed and an Accumulated Reinforcement
Authors: Park Chansol , Chung Kyong-mee
Published: June 2023

Previous studies comparing the effectiveness of the distributed and accumulated reinforcement on the intellectual and developmental disability concluded that accumulated reinforcement is more effective. However, the task difficulty, types of reinforcer, and participants’ characteristics of previous studies were limited. The present study compared the effectiveness of distributed and accumulated reinforcement on the difficult task using food reinforcer and examined whether theses effects depend on participants’ diagnostic characteristics. A total of 33 participants(19 intellectual disability and 14 autism spectrum disorder(ASD)) conducted the visuospatial working memory task under both reinforcement conditions. The dependent variables were accuracy rate, correct response per minute, response per minute. The results showed that the accuracy rate and correct response per minute were significantly higher in the accumulated reinforcement. In addition, the ASD group showed a significantly higher accuracy rate in accumulated reinforcement than distributed reinforcement, but the intellectual disability group showed no differences between conditions. These results suggest that children with intellectual disability and ASD show a better performance under the accumulated reinforcement, and the characteristics of ASD are relevant to the effects of accumulated reinforcement.
Exploring Ecological Factors Associated with At-Risk Students with Suicidal Ideation: A Decision Tree Algorithm
Authors: Hong Saahoon , Kim Eunji , Sung Junghoon , Kweon Oyong
Published: June 2023

The primary purpose of this study was to explore the ecological factors of at-risk students with suicidal thoughts among second-year middle school students, participated in the 5th year of the Gyeonggi Education Panel Study (GEPS). The decision-tree model, one of the machine learning algorithms, confirmed the intersectionality between suicidal ideation and the ecological factors of students at risk. For students who answered “strongly agree” and “not at all” to the question of suicidal ideation, mental health, attachment alienation, academic stress, gender, household income, and delinquency factors were identified as major factors with statistical significance. Based on the decision-tree model and its results, it was emphasized that it is necessary to understand the psychological and emotional needs, the home environment, and the school environment of students in crisis from an ecological perspective. In addition, the implications of the data-based approach, such as the decision tree model for School-Wide Positive Behavior Supports and the school safety integrated system (Wee project), were discussed.
The Effects of Social Autopsy Using Behavior Contingency Maps on Social Communication Behaviors of A Child at Risk for ADHD
Authors: Lee Mi Ran , Mun Hyun Mi
Published: June 2023

This study investigated the effects of social autopsy using behavior contingency maps on social communication behaviors of a 5-year-old girl at risk for ADHD. The study applied a multiple-probe baseline design across behaviors which was composed of baseline, intervention, and maintenance phase. The independent variable was social autopsy using behavior contingency maps, and the dependent variables were ‘talking to adults in honorifics’, ‘face-to-face interaction with peers’, and ‘talking with peers at an appropriate distance’. Data were collected by the event recording method and each occurrence rate was calculated. The results shows that all three social communication behaviors were effectively enhanced and maintained with a level improvement of more than 50% on average and PND of 100%. Behavior contingency maps helped a young child to understand the contents of social autopsy. This study results suggest that social autopsy using behavior contingency maps can be used as an effective intervention in order to improve social communication behaviors of young children at risk for ADHD.
Rare primary intrahepatic lithiasis in a young patient
Authors: Jovanovic Milan , Bezmarevic Mihailo , Petkovic Srdjan , Milev Bosko , Mitrovic Miroslav , Jocic Miodrag , Jovanovic Marina , Mirkovic Darko
Published: June 2023

Introduction. Intrahepatic lithiasis (IHL) is a disease that occurs in middle-aged and elderly people. Presentations of IHL in the young are rare, and considerations in the differential diagnosis include primary sclerosing cholangitis, recurrent pyogenic cholangitis, bile acid transporter defect, Caroli?s disease, and other known genetic diseases. Treatment is often complex, all in order to prevent complications. In this report, we describe the diagnosis and treatment, with the application of a flexible ureteroscope of 4 Fr, of a younger patient with intra-hepatic lithiasis. Case report. A 25-year-old man appeared with a known diagnosis of IHL and a recurrent attack of abdominal pain that required medical treatment. Magnetic resonance imaging of the abdomen showed segmental stenosis of the left bile duct and segmental bile duct for the lateral section with intraductal calculi and its proximal dilatation and mild dilatation of the bile ducts for liver segments II and III. During surgery, a cholangiography and ultrasonography of the liver were performed. Through choledochotomy, the bile ducts were flushed, and extirpation of the several calculi was performed. The bile ducts were examined with a chole-dochscope, and the remaining concrements were removed with a flexible ureteroscope. Conclusion. Segmental liver bile ducts may be explored with a flexible ureteroscope without bile duct injury or trauma. In selected cases, with isolated lithiasis in one liver lobe and the absence of concomitant diseases, IHL can be treated surgically without liver resection. This case is unique because we did not perform liver resection but duct stone extraction, which was an appropriate treatment since there was no recurrence during the two-year follow-ups.
Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations
Authors: Krantz Åsa , Carrero Juan Jesus , Yang Yuanhang , Schalin Lovisa , Lysell Josefin , Mazhar Faizan
Published: June 2023

Limited information exists regarding treatment of patients with psoriasis/psoriatic arthritis in primary care. The aim of this study is to assess treatment patterns, adherence, persistence, and compliance in newly diagnosed patients with psoriasis/psoriatic arthritis from 2012 to 2018 in Stockholm, Sweden. In addition, laboratory monitoring before initiation of treatment and at recommended intervals was quantified for patients prescribed methotrexate or biologics. A total of 51,639 individuals were included, with 39% initiating treatment with topical corticosteroids and < 5% receiving systemic treatment within 6 months post-diagnosis. During a median (interquartile range) follow-up of 7 (4–8) years, 18% of patients received systemic treatments at some point. Overall, 5-year persistence rates were 32%, 45% and 19% for methotrexate, biologics, and other systemic treatments, respectively. Pre-initiation laboratory tests, as recommended by guidelines, were performed in approximately 70% and 62% of methotrexate and biologics users, respectively. Follow-up monitoring at recommended time intervals occurred in 14–20% and 31–33% of patients prescribed methotrexate and biologics, respectively. These findings highlight gaps in the pharmacological care of patients with psoriasis/psoriatic arthritis, including suboptimal adherence/persistence and inadequate laboratory monitoring.
Prediction of diabetes mellitus after kidney transplantation using patient-specific induced pluripotent stem cells
Authors: Lim Sun Woo , Shin Yoo Jin , Cui Sheng , Ko Eun Jeong , Chung Byung Ha , Yang Chul Woo
Published: June 2023

Background: Multiple risk factors are involved in new-onset diabetes mellitus (DM) after organ transplantation; however, their ability to predict clinical prognosis remains unclear. Therefore, we investigated whether patient-specific induced pluripotent stem cells (iPSCs) could help predict DM development before performing kidney transplantation (KT). Methods: We first performed whole transcriptome and functional enrichment analyses of KT patient-derived iPSCs. Our results revealed that insulin resistance, type 2 DM, and transforming growth factor beta signaling pathways are associated between the groups of DM and non-DM. We next determined whether the genetic background was associated with development of iPSCs into pancreatic progenitor (PP) cells. Results: The levels of differentiation-related key markers of PP cells were significantly lower in the DM group than in the non-DM group. Moreover, the results of tacrolimus toxicity screening showed a significant decrease in the number of PP cells of the DM group compared with the non-DM group, suggesting that these cells are more susceptible to tacrolimus toxicity. Conclusion: Taken together, these results indicate that PP cells of the DM group showed low developmental potency accompanied by a significantly different genetic background compared with the non-DM group. Thus, genetic analysis can be used to predict the risk of DM before KT.
The Impact of the COVID- 19 Pandemic on the Values and Behaviors of Young People in Light of the Current Circumstances
Authors: Al Baher Ibrahim Ali
Published: June 2023

This study aimed to identify the impact of the Covid- 19 pandemic on the values and behaviors of young people in light of the current circumstances. The study sample consisted of (70) young men and women, who were selected in a stratified random manner. The descriptive survey method was used in the current research. To achieve the research objectives, a questionnaire was developed, and its validity and reliability were verified. The results showed that the impact of the Covid- 19 pandemic on the values and behaviors of young people in light of the economic conditions was high. In light of the social conditions, it was average, and the results of the study showed that there were statistically significant differences at the significance level (α ≤ 0.05) according to the gender variable in favor of the male category, And the presence of statistically significant differences according to the educational qualification variable, and the absence of statistically significant differences according to the years of experience variable. In light of these results, the study recommended the necessity of paying attention to the youth category as a source of the state’s strength, and working on its development. And preparing it to be able to adapt to future crises, so that it becomes an active element capable of dealing with any crisis that may pass on the economic or social level, In addition to conducting more studies on the impact of the Covid- 19 pandemic on the values and behaviors of young people, And what it caused is the change in the value system of society as a whole, and in particular of the youth group
Quality Assurance when Using Therapeutic Drug Monitoring: A Lamotrigine Split Sample Method to Reflect Comparability
Authors: G Beran Roy
Published: June 2023

Purpose: Therapeutic drug monitoring can optimise patient outcomes if the Anti-Epileptic Medication (AEM) level is received in a timely fashion. When choosing a laboratory (lab) to measure levels, the treating physician must incorporate quality assurances so as to be confident that the results are reliable and concordant with results accepted from the current lab. The study aims to generate a practical example of how one can improve the use of drug monitoring in patients with epilepsy. Methods: A split-sampling procedure was used to analyse the AEM levels reported by two different labs. The results were categorised in accordance with the physician’s defined therapeutic range: sub-therapeutic: <10mg/L; therapeutic: 10-16mg/L; and supra-therapeutic: >16mg/L, to determine if categorisation varied between the labs. Results were further evaluated to compensate for absolute and/or clinically significant differences. Results: Categories were concordant for 43/50 (86%) of results. Of the 7/50 (14%) category discordant results, five (10% of results) were not clinically significant. In only 4% (2/50) of patients was the discordance sufficient to have possibly generated a treatment modification depending upon the patient’s clinical picture. Overall, the absolute difference in the levels reported by the two labs was neither significant nor statistically different. Conclusion: Split-sampling studies are a practical way of ensuring physician confidence and demonstrating quality assurance when changing labs.
Medicinal Herbal Plants and Allopathic Drugs to Treat Diabetes Mellitus: A glance
Authors: Nimesh Saurabh
Published: June 2023

The present study was based on Diabetes Mellitus, its cure using herbal drugs over allopathic drugs. According to the official World Health Organisation (WHO) data, India tops the list of countries with the highest number of diabetics; China, America, Indonesia, Japan, Pakistan, Russia, Brazil, Italy and Bangladesh follow. In the year 2000, the total number of diabetics in India stood at 31.7 million and is expected to rise by more than 100% in the year 2030 to account to a whopping 79.4 million. Despite the use of advanced Allopathic drugs for the treatment, use of herbal remedies is gaining higher importance because of Allopathic drugs have drawbacks and limitations. Natural herbs have been highly esteemed source of medicine throughout the human history. They are widely used today indicating that herbs are a growing part of modern high-tech medicine. The herbal drugs with anti-diabetic activity are extensively formulated commercially because of easy availability, affordability and less side effects as compared to the synthetic anti-diabetic drugs. The WHO has listed 21,000 plants, which are used for medicinal purposes around the world. A list of medicinal herbal plants with proven anti-diabetic and related beneficial effects and of herbal drugs used in treatment of diabetes is compiled. Thus, this review article undertakes the attempt for providing updated information on the type of diabetes and herbal formulations which will enhance the existing knowledge of the researchers.
Current and Future Prospects of Azetidine Derivatives an Overview
Authors: Shankar Mani
Published: June 2023

Due to the intrinsic ring strain of azetidine derivatives, there are numerous challenges involved in their synthesis. Its derivatives have several important applications, such as antibacterial, antifungal, anticancer, antitubercular, antioxidant, etc. This review provides the impact of recent advances in the synthesis of azetidines and their derivatives. It gives an overview of the different therapeutic uses of azetidines, with various structures and degrees of control. This elaborate review will furnish a basis for the progress of future azetidines to fight the various microbes which have developed their resistance against current medications.
Kriittisen diskurssintutkimuksen ja positiivisen diskurssianalyysin dialogia
Authors: Halonen Mia , Nikunen Kaarina
Published: June 2023

Arvio teoksesta
Irina Herneaho: Oikeus elää. Intertekstuaalisuus turvapaikanhakijoiden oikeuksia ajavassa kansalaisaktivismissa. Helsingin yliopisto 2022. 292 s. isbn 978-951-51-8576-1. Saatavilla verkossa osoitteessa http://urn.fi/URN:ISBN:978-951-51-8577-8.
Subject Index Volume 38 Nomor 2 Desember 2022
Authors: Pax Justitia et
Published: June 2023

Subject Index Volume 38 Nomor 2 Desember 2022
Formulation Policy on Health for Abortion Actions on Disabilities Based on the Value of Legal Certainty
Authors: Santoso Budi , Ravena Dey , Susiarno Tono Hadi
Published: June 2023

This study aims to identify the policy formulation in Law No. 36 of 2009 on Health regarding abortion for fetal defects and the necessary formulation of the law to achieve legal certainty. The research method used was a literature review by analyzing legal documents and relevant literature on the issue. The analysis showed that Law No. 36 of 2009 on Health limits abortion for fetal defects to be performed only before the pregnancy reaches 6 weeks, while fetal defects usually can only be detected after 16 weeks. This causes legal uncertainty for doctors and patients. Therefore, policy formulation is needed that considers medical and moral factors to achieve legal certainty in the practice of abortion for fetal defects.
Socio-Juridical Analysis on Polygamy Requirements in the Compilation of Islamic Law (KHI)
Authors: Widiani Ah. Kholish Hayatuddin Desti
Published: June 2023

Abstract: Socio-Juridical Analysis on Polygamy Requirements in the Compilation of Islamic Law (KHI).This study is aimed at seeing the relevance of the requirement for polygamy in Law no. I of 1974 concerning marriage and in the Compilation of Islamic Law (KHI) including its implementation in several decisions on polygamy cases in the Religious Court (PA) of Ex Surakarta Regency. This type of research is field research using a socio-juridical approach. The results of this study conclude: 1) The requirements for polygamy as regulated in Law no. I of 1974 and KHI are complementary. While Law no. I of 1974 in article 5  specifies five conditions for polygamy, KHI mentions only three conditions. 2) In general, the reasons put forward by husbands for polygamy are always related to the condition of the wife who is unable to carry out her obligations. 3) Judges, in deciding polygamy cases, do not only base the reasons put forward by the husband but also make other considerations, especially related to matters of the benefit and welfare of the applicant’sfamily
POTENTIAL OF WAQF INSTRUMENT IN TOURISM INDUSTRY IN MALAYSIA
Authors:   Academy of Contemporary Islamic Studies (ACIS), Universiti Teknologi MARA Melaka, Che Man Norajila , Abd Wahab Nor Azlina ,   Academy of Contemporary Islamic Studies (ACIS), Universiti Teknologi MARA Melaka, Ab Hamid Norafifah ,   Academy of Contemporary Islamic Studies (ACIS), Universiti Teknologi MARA Melaka, Nordin Rawi ,   Academy of Contemporary Islamic Studies (ACIS), Universiti Teknologi MARA Melaka
Published: June 2023

Waqf is one of the essential instruments in developing the economy of the Muslims. The role of waqf is not only limited to intrinsic worship but it also covers all areas of development such as education, health, economic activities, agriculture and so on. Waqf can also play its role in developing the tourism industry which is one of the activities recommended in Islam as tourism is a platform to develop the society in terms of culture, heritage, society and economy. In Malaysia, the tourism industry acts as one of the main sectors contributing to the country’s economic growth. The practice of waqf in tourism in Malaysia can be viewed through the efforts made by JAWHAR and other agencies due to the awareness of ensuring waqf properties are developed through a contemporary approach. This paper focuses on the role of waqf in Islamic-based tourism sector in Malaysia. Key Words: Waqf, Islamic Tourism, Tourism Industry
THE HYBRID OF WAQF LAND AND ZAKAT FUND DEVELOPMENT: A CASE STUDY FOR PROTECTING ASNAF FISABILILLAH WELL-BEING
Authors:   Department of Estate Management, Universiti Teknologi MARA (Perak), Seri Iskandar Campus, Perak, Malaysia, Mohd Ali Siti Nadiah , Mokhtar Salbiah ,   Department of Estate Management, Universiti Teknologi MARA (Perak), Seri Iskandar Campus, Perak, Malaysia, Mohd Noor Abdul Halim ,   Accounting Research Institute, Universiti Teknologi Mara, 40450 Shah Alam, Selangor,Malaysia
Published: June 2023

This research purpose is to explore the hybrid of Waqf land and zakat fund in the development of asnaf fisabilillah needs. Due to the current situation, asnaf fisabilillah in the context of zakat division in modern time interpretation can be used to design socio-economic development and to uphold the symbolism of Islam. The significant value of understanding this issue will undergo qualitative research based on a paradigm of strategic management theories to suit the internal and the external needs of Pahang SIRC. Using purposive sampling, Pahang SIRC has been chosen to be part of the study where rich data got from the semi-structured interview with three officers. The data were taped, transcribed and analyzed using coding analysis for multiple interviews. Our results inform that, from Pahang SIRC officer’s perspective, there is a need in the hybrid between Waqf land and zakat fund to the well-being of asnaf fisabilillah. The officers are more worried about the benefits of interest they give to the asnaf fisabilillah are insufficient, so that the collection of zakat fund needs to be in the "house." The finding shows that Pahang SIRC has two projects that involved asnaf fisabilillah in the combination of Waqf land and zakat fund. In summary, this study provides some discussion of the single case study which represents a hybrid of Waqf land, and zakat is a comprehensive collaboration within SIRC unit in their operation. The awareness of the knowledge of Waqf land and zakat from the shariah and management principles give a broader perspective to the professionals in Pahang SIRC to contribute to the target group. Keywords: Well-being; Waqf land; Zakat Fund, Asnaf fisabilillah
WEATHER CHANGES INFLUENCE THE CRIME ACTIVITY TOWARDS THE QUALITY OF LIFE
Authors:   Faculty of Architecture, Planning and Surveying, Universiti Teknologi MARA, Perak Branch, Seri Iskandar Campus, Mohd Zukri Anis Zulaikha , MD Sakip Siti Rasidah ,   Faculty of Architecture, Planning and Surveying, Universiti Teknologi MARA, Perak Branch, Seri Iskandar Campus,   Green Safe Cities Research Group, Universiti Teknologi MARA, Shah Alam Campus, 40450 Selangor, Masrom Suraya ,   Faculty of Computer and Mathematical Science,Universiti Teknologi MARA, Tapah Campus, Perak Branch, Malaysia
Published: June 2023

The controversy over weather changes will lead to more stress, less social control, reduced social support, criminal tendencies, more possibilities for crime, and societal conflict. The factors driving criminal activity have received much attention, and voluminous literature has related the incidence of changing weather changes to criminal activity. However, weather variables can affect the environment and human behaviour differently. For example, past scholars found that homicidal crime has a connection with the weather change. However, although studies look at the relationship between crime and weather change, the source of the data is debatable. In addition, empirical studies showing the relationship between property crime and weather change are challenging to obtain because none can be found. Therefore, this paper aims to identify the pattern of criminal activity based on weather changes to address this situation. In this paper, the research methodology uses quantitative data. The crime data were gathered from the Royal Malaysia Police (RMP), and the weather data was gathered from Meteorological Department for Selangor, Kuala Lumpur, and Johor from 2011 to 2020. The data were analysed using SPSS statistical and illustrated in the bar graph method to identify the pattern and relationship between crime and weather. This study found that non-aggressive and property crime is less influenced by the high temperature but influenced by the ambient temperature and humidity. Future research on the relationship between crime and weather towards the quality of life of people must be theoretically grounded and use measures of crime and weather that are justified by the quality-of-life index theory.
La continuidad de un vínculo. Hijos y padres en la literatura argentina contemporánea
Authors: Fontana Patricio
Published: June 2023

Los textos en los que un hijo cuenta la vida de su padre y las vicisitudes de la relación que mantuvieron conforman un subgénero de la escritura biográfica. Este subgénero, que recibe en inglés dos denominaciones (patriografhy y patremoir), resulta especialmente útil para inquirir la índole del vinculo entre biografo y biografiado. En este artículo se ofrece un primer acercamiento a un conjunto de patriograrfías publicadas en la Agentina en las dos últimas décadas que hace foco en cómo en ellas aparece ese vínculo: ese “nosotros” conformado por padre e hijo. Además, se analiza cómo estos textos casi siempre tematizan, de diversas maneras, tres cuestiones: muerte, conversación y vocación. Asimismo, se postula que más allá de las intenciones del hijo-biografo con respecto a su padre en particular, la patriografía es siempre un espacio textual en el que se trama alguna foma de la afiliación o de la continuidad.