bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of platelet rich plasma treatment in a young athlete with osgood schlatter disease and patellar tendinopathy, suffering from familiar mediterranean fever A case report
Authors:   Department of Translational Biomedicine and Neuroscience DiBraiN, Aldo Moro University, 70121 Bari, Italy., Amico Angelo Paolo
Published: November 2023

Background Osgood-Schlatter Disease OSD is one of the most common causes of anterior knee pain in children and adolescents. It is a condition with a tendency to self-resolve, and as a result, treatment is symptomatic.
Introducing Transformative Plant Biotechnology: Building a molecular toolkit to understand Begonia evolution
Authors: Turnbull Lucy
Published: November 2023

With a pantropical distribution and over 2000 described species, Begonia is an understudied angiosperm genera. In particular, high diversity and multiple whole-genome duplication events make Begonia an excellent model to investigate the fates of duplicated genes and how evolution has modified gene function in different paralogs and different lineages. Sequence analysis reveals high level of copy number variation and variation in conserved regions of key leaf development genes. To discover the impact of theses changes on function we need to establish genetic engineering techniques in Begonia. We have created a pipeline to establish shoot regeneration through tissue culture in any Begonia species, which we are extending to establish stable transformation. We have also developed a transient transformation protocol to use for molecular subcellular localisation assays.
Pemanfaatan Teknologi Pompa Portabel Tenaga Surya untuk Sistem Irigasi Kebun
Authors: Jaya Harie Satiyadi , Rahmat Hudan , Sukardi Sukardi
Published: November 2023

The Community Service Program (PKM) aims to solve the problems faced by farmer group partners, such as: (1) unequal financial capabilities in each member of the farmer group, (2) less good agricultural yields if smoke appears during the long dry season, and (3) high operational costs because they depend on fuel consumption for the plant watering process. The implementation of core activities in this PKM program consists of two stages, namely; (1) solar cell pump assembly training to provide solutions for partners who are not familiar with solar-powered portable water pump technology and still depend on using fuel pumps as a means of watering plants, and (2) solar cell pump operation and maintenance training to provide solutions for partners who cannot operate and maintain solar-powered portable water pumps.
Treatment results of acute arterial obstruction of the lower limbs during advanced stages of ischemia
Authors: Gaibov A. D. , Sultanov D. D. , Ne’matzoda O. , Abdusamadov K. A. , Shokhsavorbekov A. S. , Kamolov R. S.
Published: November 2023

Objective. To analyze the immediate results of treatment of patients with acute arterial obstruction of the lower limbs during advanced stages of ischemia.

Material and methods. The results of a comprehensive examination and treatment of 244 patients (135 men, 109 women, average age 67,2±8,4 years) with acute arterial obstruction of lower limbs were analyzed. Acute thrombosis was observed in 105 (43,1%) patients and embolism of the main arteries in 139 (56,9%) patients. 197 (80.7%) patients had ischemia of one (102 left, 95 right lower limbs) and 38 (15.6%) of both lower limbs. In 244 patients acute ischemia was noted in a total of 281 lower extremities. 86.9% of patients were hospitalized 24 hours after the onset of the disease. In 190 cases the affected limbs had II degree ischemia (54 cases (19,2%) of IIA degree, 136 (48,4%) IIB degree), and 91 (32,4%) patients had ischemia of III degree.

Results and discussion. The main component of the operation for vascular embolism was thromboembolectomy (n=110), which in 56 cases was supplemented by vessel reconstruction (n=13), fasciotomy (n=34), and necrectomy (n=12). Primary amputation of the limb was performed in 13 cases. Conservative angiotropic therapy was performed in 16 cases.

In acute thrombosis of lower limb arteries, conservative treatment was performed in 28 cases, primary limb amputation was performed in 10 cases, thrombectomy with a local reconstruction of the vessel (n=31), also with bypass (n=14), with reconstruction and fasciotomy of the tibia (n=13) and with reconstruction and necrectomy (n=7) were performed in 93 cases.

Conclusion. Despite the delayed treatment in 67.6% of cases, the acute ischemia presented less severely, suggesting that the level of obstruction is more influential than the timing of the onset in the development of ischemic limb injuries. The choice of treatment method and extent at advanced stages of limb ischemia primarily depends on the degree and severity of ischemic disorders. The outcomes of treatment were less satisfactory in acute arterial thrombosis than in embolism, largely due to chronic obliteration of the distal arterial channel.
Analysis and modeling for calculation the need for x-ray therapy systems in Tajikistan
Authors: Zuenkova Yu. A.
Published: November 2023

Objective. To analyze the needs of the Republic of Tajikistan in radiotherapy equipment.

Materials and methods. A comprehensive bibliographic and informational search was employed, accompanied by a semantic analysis. Scientific literature and regulatory legal documents were reviewed, and an economic mathematical modeling method was utilized.

Results. The demand for radiotherapy devices in Tajikistan can be determined through three models: “by the number of the population served” 12 devices, “by the number of oncological dispensaries in the country” 5 units, “by oncological prevalence” (Lean management approach) one system. The proposed models should be adjusted taking into account the territorial accessibility of the method for the population, current clinical recommendations, as well as the availability of other radiotherapy equipment.

Conclusion. X-ray therapy is of particular interest to the organization of oncological care due to the low cost of devices in comparison with other radiotherapy equipment, as well as the low cost of their maintenance, high operational efficiency, and ease of use. Heads of medical institutions need to know different approaches to calculate the needs.
Treatment of Hirschsprung’s disease in young children
Authors: Mirzoev D. S. , Ibodov H. , Yakhshibekova Sh. I. , Rofiev R. R. , Kromov T. Sh. , Latipov Sh. E.
Published: November 2023

Objective. The objective of this study was to optimize the treatment for Hirschsprung’s disease in young children.

Material and methods. A total of 71 children, ranging in age from 3 days to 3 years, were observed. Patients were categorized into three groups based on the surgical procedure performed: 23 underwent transanal endorectal proctoplasty according to De La Torre Mondragon (32.4%), 17 according to the Swenson-like method (23.9%), and 31 according to Soave-Lenyushkin (43.7%).

Results and discussion. The results of the maternal examination revealed the presence of cytomegalovirus, herpes virus and toxoplasmosis. The basis for the success of surgical treatment is timely diagnosis. After surgical intervention, histological examination of the surgical material confirmed intestinal agangliosis. Peritoneal-promesenteric proctoplasty according to SoaveLenyushkin in the modification of the clinic, with wedge-shaped excision of the serous-muscular case, is effective in terms of prevention of inter-sheath hematomas and fluid accumulation. The De La Torre-Mondragon and Swenson-like technique of transanal endorectal relegation, without abdominal access with demucosation of the rectum, is considered an effective and minimally invasive access for rectal and rectosigmoidal forms of Hirschsprung’s disease.

Conclusions. Transanal endorectal relegation at an early age in children showed rapid recovery of intestinal motility in the postoperative period without skin incision. The results of early surgical intervention contribute to the achievement of good results in the immediate and distant period after the surgical intervention.
Personalized tactics for the treatment of nephrolithiasis in the intrarenal pelvis
Authors: Murotov Kh. M. , Shamsiev J. A. , Ruziboyzoda K. R. , Kosimov M. M. , Abduvokhidov A. A. , Sadulloev F. S. , Ashuraliev N. K. , Rashidov B. J.
Published: November 2023

Objective. Improving the results of treatment of nephrolithiasis in the intrarenal pelvis.

Material and methods. The study involved 154 patients with nephrolithiasis in the intrarenal pelvis. They were divided into two groups: the main group comprised 78 (50.6%) patients who underwent personalized surgical procedures using modern technologies, while the control group of 76 (49.4%) patients received conventional one-stage traditional surgical interventions. Results. In the main group, one-stage percutaneous puncture nephrolithotripsy was conducted for 55 patients, representing 70.5% of the cases. However, in 5 (6.4%) cases of complex variants of nephrolithiasis, it was required to convert the access to a lumbotomy with subcortical pyelolithotomy. Of note, 11 patients (14.1%) presented with either complicated purulent calculous pyelonephritis (5 patients) or II-degree hydronephrosis (6 patients). For these patients, the treatment was staged. Initially, a nephrostomy was carried out using ultrasound guidance. Following this, 7 patients underwent percutaneous puncture nephrolithotripsy, while 4 patients had a lumbotomy subcortical pyelolithotomy paired with nephrostomy. In another subset of the main group, 12 patients (15.4%) required one-stage traditional surgery through lumbotomy access due to specific medical criteria. Patients in the control group (n=76) underwent open libotomy for removal of kidney stones. Postoperative complications in patients of the main group were noted in 7 (9.0%) cases, with no lethal outcomes. Whereas in patients of the control group, postoperative complications occurred in 18 (23.7%) cases. Lethal outcomes were recorded in 3 (3.9%) cases.

Conclusion. In determining the appropriate surgical approach for patients with nephrolithiasis in the intrarenal pelvis, it’s essential to prioritize a personalized treatment plan. Minimally invasive interventions are recommended wherever possible
Diagnosis and minimally invasive methods of treatment of intra-abdominal postoperative complications
Authors: Azizzoda Z. A. , Sangov M. B. , Safarov F. S.
Published: November 2023

The article offers a review of contemporary literature focusing on the diagnosis and treatment of intra-abdominal postoperative complications using minimally invasive techniques. The literature analysis underscores that there is a substantial body of knowledge worldwide regarding the use of minimally invasive approaches, including relaparoscopy and percutaneous methods, in treating intra-abdominal postoperative complications. The literature suggests that employing these minimally invasive techniques has enhanced treatment outcomes and lowered economic costs. However, in spite of these advancements, clear guidelines and comprehensive surgical algorithms for addressing postoperative complications using these techniques remain underdeveloped.
THE IMPACT OF THE SANCTIONS ECONOMIC SHOCK ON RUSSIAN REGIONS
Authors:   Institute for Regional Economic Studies Russian Academy of Sciences, Pesotskiy Andrey A.
Published: November 2023

The economic sanctions imposed in 2022 had a negative impact on Russian regions. The sanctions represent an economic shock, the article formulates its refined definition and considers its classification attributes. The aim of the study is to analyze the shock caused by the economic sanctions imposed on Russia. To conduct the analytical part of the work, a set of methods for collecting and processing information was used, including generalization, modeling, abstraction, and comparative analysis. To perform the mathematical part, the principal component analysis and R programming language were used. The novelty of the study lies in the clustering of the subjects of the Russian Federation, based on the degree of damage from the sanctions shock. The practical significance is due to the severity of the geo-economic confrontation, in which the socioeconomic systems of the Russian regions are involved. The conclusion of the study is that the reaction of Russian regions to the sanctions impact in 2022 differs from the reaction to the pandemic impact in 2020 by the high homogeneity of processes in most subjects of the Russian Federation. The further direction of the study implies confirmation or refutation, as well as the development of the obtained results by means of other ways of studying regional shocks.
CORRUPTION AS A BRAKE ON THE SUSTAINABLE DEVELOPMENT OF THE RUSSIAN STATE AND SOCIETY (USING EXAMPLES FROM THE PRACTICE OF ST. PETERSBURG)
Authors:   St. Petersburg State University of Aerospace Instrumentation, Bulatov Rashid B.
Published: November 2023

The article examines the issues of such a dangerous socially negative phenomenon of a criminal nature as corruption, which hinders the sustainable development of Russian society and defines Russia in the world community as a country with a high level of corruption, contributing to its economic collapse and the destruction of the system of state power and management. The concept of corruption, its causes and forms is revealed, the classification of corruption-related crimes is given. The research is mostly based on the practice of St. Petersburg in the fight against corruption by law enforcement agencies and the prevention of corruption manifestations. The material is replete with examples of judicial practice concerning corruption crimes; statistical data characterizing the level of corruption in the Northern capital.
PECULIARITIES OF DEVELOPMENT OF THE REAL ESTATE MARKET IN ST. PETERSBURG DURING THE CRISIS PERIOD
Authors:   Peter the Great St. Petersburg Polytechnic University, Pupentsova Svetlana V. , Bondarenko Alina V. ,   Peter the Great St. Petersburg Polytechnic University
Published: November 2023

The features and prospects of development of the primary real estate market of St. Petersburg during the crisis period have been revealed, the volume of demand for real estate in the primary market of St. Petersburg has been estimated, the price dynamics in the primary and secondary real estate market of St. Petersburg for the period January 2020 – April 2023 has been presented. The main trends, problems and prospects of the retail real estate market have been revealed. The dynamic series of attendance rates in the shopping malls in 2022, the level of occupancy of retail facilities, the dynamics of rental rates for anchor tenants and space in the retail gallery were plotted. The levels of operating costs and profitability indicators for retail space have been revealed. The methods of synthesis, induction (inductive generalization (empirical)), concretization, comparison and analysis of dynamic series have been used in the work. The authors came to the conclusion that the prerequisites listed in the article for the analyzed period (demand decrease, economic crisis, drop of real incomes of population) will contribute to the reversal of growth tendency to the reduction of prices on the primary and secondary real estate market of St. Petersburg. It was noted that the crisis in the market of retail real estate in Saint-Petersburg has its own characteristics and requires from entrepreneurs to make non-standard decisions and be ready for the changes in the market.
THE ROLE OF GENERATIVE AI MODELS AND THE PHENOMENON OF GPT-TYPE NEURAL LANGUAGE MODELS IN DETERMINING THE DIGITAL ECONOMY
Authors:   St. Petersburg State University of Aerospace Instrumentation, Peshkova Galina Yu. , Fedorov Konstantin F. ,   St. Petersburg State University of Aerospace Instrumentation
Published: November 2023

LLM such as ChatGPT have the potential to revolutionize research in economics and other sciences. New technologies tend to save labor and resources, stimulating the optimization of most economic processes. The article reviews the main prospects of development of generative models of artificial intelligence and neural language models. An analysis of examples of the use of artificial intelligence tools in economics is conducted. Particular attention is paid to recent trends and current problems in the development of machine learning, artificial intelligence and neural networks. Since the digital transformation of the economy is all-encompassing, AI developments are making it much easier for humans to interact with advanced technologies. This reduces the time it takes to perform various tasks and increases productivity.
THE ROLE OF THE NORTH-WEST REGION IN THE DEVELOPMENT OF THE RUSSIAN MARKET OF LIQUEFIED NATURAL GAS
Authors:   Institute for Regional Economic Studies Russian Academy of Sciences, Okrepilov Vladimir V. ,   St. Petersburg State University of Aerospace Instrumentation, Peshkova Galina Yu. ,   St. Petersburg State University of Aerospace Instrumentation, Bondar Elena G. ,   St. Petersburg State University of Aerospace Instrumentation
Published: November 2023

The article is devoted to assessing the prospects for the development of the liquefied natural gas market in the context of modern challenges, threats and risks. The Russian scientific works and inventions related to the study of the production, application, storage, and supply of liquefied natural gas to the world market are analyzed. It is determined that Russia has the necessary potential for domestic consumption and export of the energy resource in question to foreign countries. The importance of the North-Western Federal District in the implementation of projects important for the development of the liquefied natural gas market in Russia and the country’s retention of leading positions in the global energy market is shown.
PROBLEMS OF IMPLEMENTING DIGITALIZATION INNOVATIONS IN PRODUCTION PROCESSES
Authors:   Peter the Great St. Petersburg Polytechnic University, Izmailov Maxim K.
Published: November 2023

The article is devoted to current problems of implementation of digital innovations in production processes. The author of the article identifies the most pressing issues regarding the success of the national program for the digitalization of the economy. The author notes that in the current economic and geopolitical crisis, the Russian Federation is in dire need of renovation of production processes based on modeling them with the help of innovative technologies. The author draws attention to the lack of any alternative to the national strategy for digitalization of the economy and suggests extending it with additional tactical and strategic solutions, which will help to overcome the economic crisis, as well as to ensure a sufficient degree of digital technology integration. The author notes that in the Russian Federation there is a particularly acute problem in the field of integration of innovative technologies – a quantitative shortage of highly qualified personnel in the digital sphere, as well as the recently observed emigration of IT industry specialists. In addition, the author notes the low motivation of employees of Russian companies to integrate digital technologies into their production process, which negatively affects economic productivity and security. Issues of technological sovereignty are particularly important today, which is why the author notes the need to attract investment to create their own digital production facilities. The author of the article also proposes to integrate digital technologies into management decision-making processes, which are directly related to the risks of optimizing production processes. The introduction of artificial intelligence in this area will make business more agile and adaptable in a potential economic crisis.
RESEARCH DEVELOPMENT OF THE NORTH-WESTERN FEDERAL DISTRICT POPULATION’S QUALITY OF LIFE BASED ON THE APPLICATION OF THE QUALITY ECONOMICS METHODOLOGY
Authors:   Institute for Regional Economic Studies Russian Academy of Sciences, Okrepilov Vladimir V. , Gagulina Natalya L. ,   Institute for Regional Economic Studies Russian Academy of Sciences
Published: November 2023

The article shows the problem of the scientific base forming for systematic comprehensive quality of life studies at the regional level to be provided, which is also relevant for the purposes of strategic planning and management. A meaningful research analysis of the quality of life at the regional level is carried out, the advantages and disadvantages of rating assessments are shown, the methodological basis for obtaining scientifically proven results of assessing and analyzing region’s quality of life is disclosed. The field of theoretical studies of the Northwestern Federal District population’s quality of life is characterized by substantial and methodological gaps that are evidenced by presented in the article results of a comparative analysis of Russian quality of life studies that are conducted at the regional level. In this regard, the application of quality economics methodology in order to achieve the set goals of regional development is proposed. The application of a multi-level quality management system for solving promising tasks and improving the quality of life in the region is justified. There are also recommendations on the Methodology application developed by the authors for assessing the quality of life that is built on the conceptual basis of the quality economy for assessing and analyzing the quality of life of the Northwestern Federal District.
Mosquito Detection and Classification Using Machine Learning Algorithms
Authors: Alubedy Ahmad
Published: November 2023

Accurate assessment of mosquito population density is crucial for the efficient management of mosquito-borne diseases such as malaria and dengue in areas affected by these vectors. Nevertheless, the traditional approach of manually counting and classifying mosquitoes through the use of traps is both laborious and expensive. This research paper presents a proposed pipeline for the identification and categorization of mosquitoes from photographs, specifically designed for low-cost Internet of Things (IoT) sensors. The pipeline aims to achieve a balance between accuracy and efficiency. Through the process of fine- tuning conventional machine learning models such as VGG16, RESNET50, and Convolutional Neural Network (CNN), a notable level of accuracy of 98% is attained. The present study highlights the potential of integrating a highly effective mosquito detection device with a convolutional neural network to offer a viable balance between precision and efficiency in the realm of mosquito identification, categorization, and quantification. Consequently, this approach has promise for improving the control and prevention of mosquito-borne illnesses.
Bilateral tubal pregnancy: An unusual presentation of a rare case
Authors: Thi Da Wynn , Wright Hannah
Published: November 2023

Introduction: Bilateral tubal pregnancy (BTP) is the rarest form of ectopic pregnancy. The reported incidence of spontaneous BTP is 5 in 1 million deliveries.

Case Report: A 34-year-old woman with a previous diagnosis of right tubal pregnancy who had undergone surgery three weeks before presented with persistent pregnancy symptoms and abdominal pain prompting further investigation. Subsequently, bilateral tubal pregnancy was diagnosed after she underwent a second surgery for another ectopic pregnancy on the left side of the tube. Notably, both ectopic pregnancies were confirmed by histological examination.

Conclusion: This case highlights the importance of clinical awareness of the possibility of bilateral tubal pregnancy even after a patient has recently undergone surgery for an ectopic pregnancy.
Diyabetli Gebelerin İnternet Kullanımları ve İnternet Yoluyla Karar Alma Durumlarının İncelenmesi
Authors: DEMİRAĞ Hatice , HİNTİSTAN Sevilay , DİNÇ Mücella , FİDAN UÇAN Meral
Published: November 2023

Amaç: Bu çalışma, diyabetli gebelerin internet kullanımları ve internet yoluyla karar alma durumlarını incelemek amacıyla yapıldı.

Yöntem: Tanımlayıcı ve kesitsel tasarımda gerçekleştirilen bu çalışmanın örneklemini X Devlet Hastanesi Kadın Doğum Polikliniği ve Gebe Okulu’nda takip edilen 179 diyabetli gebe oluşturdu. Veriler, 1 Mart 2022 - 1 Mayıs 2022 tarihleri arasında “Kişisel Bilgi Formu” ve “Gebelerde İnternet Yoluyla Karar Alma (GİYKA) Ölçeği” kullanılarak toplandı. Verilerin değerlendirilmesinde, One-way ANOVA ve post hoc multiple comparisons test, Mann-whitney-U ile Independent Samples t parametrik testleri; Kruskall Wallis H testi ile ileri uygulama Mann Whitney-U non-parametrik testleri ve sayılarla yüzdelik dağılımlar kullanılmıştır.

Bulgular: Diyabetli gebelerin internet yoluyla karar aldıkları (%44.7), cep telefonu ile internete erişim sağladıkları (%95.5), bilgiye erişimin kolay olması nedeniyle (%74.3) her gün internet kullandıkları (%75.4) belirlendi. Diyabetli gebelerin GİYKA ölçek toplam puan ortalaması 32.64±8.11, “öz yeterlilik algısı” alt boyutu puan ortalaması 15.58±4.10 ve “öz kontrol algısı” alt boyutu puan ortalaması 17.06±4.52 olarak bulundu. Gebelerin diyabet türü ve gebelik haftası ile GİYKA ölçek toplam puan ortalaması arasında (p
Dorothea Elizabeth Orem’in Öz-Bakım Yetersizlik Kuramına Göre KLL (Kronik Lenfositer Lösemi) Hastalığı Olan Covid-19 Hastasının Bakımı (Olgu Sunumu)
Authors: AKÇOBAN Sümeyye , TOSUN Betül
Published: November 2023

Kronik Lenfositer Lösemi (KLL) bireylerin yaşam kalitesini önemli ölçüde etkileyen hematolojik bir kanser hastalığıdır. KLL ve eşlik eden bir kronik hastalığın olması bireyin vücudunu olumsuz etkileyerek alacağı veya almış olduğu onkolojik tedaviyi negatif yönde etkilemektedir. Yapılan araştırmalarda; tüm dünyada çok sayıda ölüme neden olan COVID 19’un onkolojik tedavi gören bireyleri olumsuz etkilediği belirlenmiştir. Özellikle hastanelerde yatan kanser ve Covid 19 tanılı bireylerin sağlığına kavuşmasında hemşirelerin büyük rolü olmuştur. Hasta bireyin sağlığının geliştirilmesi, korunması, tedaviye ve hastalığa uyum sürecinde hemşireler bireye yardım ederek; öz bakım ve hemşirelik sistemleriyle ilgili uygulamaları yapmaktadır. Orem hemşirelerin, bireyin bağımsız fonksiyonunu destekleyerek; sağlıktan sapma durumunda yardım ve rehberlik etmeleri gerektiğini ifade etmektedir. Dolayısıyla bu çalışmada KLL ve COVID-19 tanılı bir hastanın bakımı Orem’in Öz-Bakım Yetersizlik Kuramına göre planlandı, uygun girişimler uygulandı ve sonuçları değerlendirildi. Hastanın hemşirelik bakım planı evrensel öz bakım, gelişimsel öz bakım ve sağlıktan sapma öz bakım gereksinimi çerçevesinde ele alındı. Sonuç olarak Orem’in Öz-Bakım Yetersizlik Kuramı doğrultusunda verilen hemşirelik bakımının hastada olumlu etkilerinin olduğu görüldü.
Experiences of Women with Visual and Orthopedic Disabilities in Obstetrics and Gynecology Units: A Phenomenological Study
Authors: TOPALOĞLU ÖREN Ekin Dila , ERTEM Gül
Published: November 2023

Experiences of women with visual and orthopedic disabilities in obstetrics and gynecology units: A Phenomenological Study

ABSTRACT

Objective: This research was conducted to understand the core/base of the experiences, thoughts, and feelings of women with visual and orthopedic disabilities about health care services related to obstetrics and gynecology units.

Bu araştırmanın amacı, görme ve ortopedik engelli kadınların obstetri ve jinekoloji birimleri ile ilgili yaşadıkları deneyimlerini, düşüncelerini ve hislerini anlamaktır.

Methods: A descriptive phenomenological design was used in this study. This study was conducted with women with 10 visual and 12 orthopedic disabilities registered to physical disability associations in Izmir, western Turkey, between May 2020 and November 2020. Data were collected by in-depth interview method using semi-structured questions. All transcripts were evaluated by two researchers and codes were created. The codes formed the sub-themes in terms of similarities and differences, themes were created as a result of combining sub-themes.

Results: The data obtained consists of two main themes: 1) 'Challenges and Problems' 2) 'Health Professionals'. 'Challenges and Problems' has 10 sub-themes: Social pressure, dependence on others-helplessness, problems with gynecology/obstetrics examination chairs, transportation problems, poor physical conditions, financial problems, procrastination/disregard, obscurity-uneasiness, privacy-shame-hesitate, and discourses in the past. 'Health Professionals' and it has four positive sub-themes and eight negative sub-themes. Positive sub-themes; introducing-describing the physical environment, helping, giving information before the procedure, being understanding and relevant. Negative sub-themes; not taking enough time-disinterest, exclusion- stigma, violence, maltreatment from female healthcare professionals, communication problems, lack of privacy, helplessness, and lack of education/awareness.

Conclusion: In the study, it was concluded that women with visual and orthopedic disabilities experienced problems, negative thoughts and feelings related to the attitudes and behaviors of individual, environmental, social, institutional, economic, information and health professionals related to obstetrics and gynecology units.Therefore, women health policies should concentrate on problems experienced by women with visual and orthopedic disabilities and health professionals in obstetrics and gynecology units.

Keywords: Disability; visual disabilities; orthopedic disabilities; obstetrics and gynecology units; phenomenology.

Financing

All persons listed as authors participated sufficiently in this study to accept public responsibility for the manuscript content. This article did not receive any funding from public or private entities.
Caracterización de la Proporcionalidad Terapéutica desde una perspectiva Bioética: Una revisión bibliográfica
Authors: Haro G. Sebastián A. , Gützlaff I. Derek U. , Jara V I. Matías A.
Published: November 2023

INTRODUCCIÓN: El desarrollo vertiginoso en la técnica medica ha traído a discusión con mayor frecuencia los aspectos éticos de los tratamientos. Si bien es evidente que la gravedad potencial de una entidad patológica debe relacionarse con un abordaje terapéutico de intensidad acorde, no es raro que a opinión experta dicho manejo no siempre es proporcional, pudiendo ser una causa de daño físico, psicológico o social que no justifica su uso para tratar la patología primaria. Esta situación hace imprescindible una reflexión profunda sobre su concepción e implicaciones. DESARROLLO: El concepto clave hallado en múltiples definiciones fue “equilibrio”, eje central a la hora de abordar el concepto de forma correcta. Respecto a los criterios, deben integrarse miradas clínicas y económicas, así como también aspectos esencialmente humanos, situando al paciente en el centro del abordaje. CONCLUSIONES: No existe un abordaje universal y sistematizado que unifique la lex artis respecto al tema en cuestión. La humildad en reconocer los límites de la medicina actual debe ir de la mano con reflexiones cada vez más integrativa de las distintas esferas que en su conjunto definen al paciente tratado y la debida proporcionalidad de dicho tratamiento. Este nuevo enfoque debe, además, ser parte integral de la atención clínica cotidiana y no solo limitar su potencial pertinencia en el ámbito de los cuidados paliativos y del fin de vida.
Trauma ocular secundario al uso de bombas lacrimógenas durante las manifestaciones sociales en Chile
Authors: Silva Orias César , Sepúlveda Bravo Andrés , San Martín Campos Catalina , Rodríguez Vega Álvaro
Published: November 2023

Introducción: Las bombas lacrimógenas (BL) son herramientas de dispersión en contexto de movilizaciones, generando principalmente molestias temporales a nivel ocular, cutáneo y respiratorio. Hay escasos registros de lesiones oculares traumáticas por BL.

Objetivos: Describir una serie de casos de trauma ocular (TO) secundario a BL que consultaron a la Unidad de Trauma Ocular del Hospital del Salvador entre el 18 de octubre y 30 de noviembre de 2019.

Materiales y Métodos: Estudio descriptivo observacional. Se analizaron datos demográficos, diagnóstico principal y secundarios, presencia de TO grave, agudeza visual (AV) al ingreso y necesidad de cirugía.

Resultados: Se incluyeron 32 pacientes, 28 hombres (87,5%) y 4 mujeres (12,5%). La edad promedio fue 32,3 años (rango 16-51). El diagnóstico principal fue TO cerrado en 20 casos (62,5%), y TO abierto en 9 (28,1%). Según criterios de Garantías Explícitas de Salud, 26 (81,3%) fueron catalogados como TO grave. 23 pacientes (71,9%) ingresaron con algún grado de déficit visual, destacando 10 pacientes (31,3%) cuya AV al ingreso fue catalogada como ceguera. 8 pacientes (25%) necesitaron cirugía, siendo lo más frecuente el cierre de TO abierto (50%) y la evisceración del contenido intraocular (37,5%).

Discusión: Las BL son usadas frecuentemente por las fuerzas de orden para dispersar manifestaciones debido a su capacidad para generar discapacidad temporal. Sin embargo, pueden generar graves consecuencias a la salud, incluida la secuela visual permanente.
Kontekstualisasi Modern Slavery (Analisis Hermeneutika Double Movement Fazlur Rahman)
Authors: Huzaifah
Published: November 2023

Modern Slavery (Perbudakan Modern) tersembunyi di depan mata dan sangat terkait dengan kehidupan di setiap sudut dunia. Setiap hari, orang ditipu, dipaksa untuk masuk ke dalam situasi eksploitatif yang tidak dapat mereka tolak atau tinggalkan. Modern slavery memiliki banyak bentuk dan dikenal dengan berbagai nama. Dalam segala bentuknya, praktik tersebut secara sistematis menghilangkan kebebasan seseorang untuk keuntungan personal dan komersial. Praktik modern slavery ini sangat bertentangan dengan nilai Qur’ani. Al-Qur’an mengedepankan kebebasan manusia, dan menghendaki perubahan sosial secara universal dengan memuat ayat-ayat tentang perbudakan. Adapun penelitian ini merupakan penelitian kualitatif (library research) dengan metode deskriptif-analitis, hasil penelitian ini menunjukkan bahwa kontekstualisasi modern slavery kini merupakan lebih berbahaya terhadap humanisme, yakni perbudakan pemikiran, perbudakan ekonomi, kekuasaan, bahkan kemerdekaan suatu negara. Ideal Moral (Pesan moral ) dalam teori double movement Fazlur Rahman dalam  memerdekakan budak yaitu memberikan kesetaraan kepada orang lain, membebaskan dari penindasan, dan tidak mengganggu hak asasi manusia dalam bentuk apa pun itu.
Ultrasonic vibration measurement using heterodyne interferometry and SDR phase meter
Authors: PHẠM VĂN ĐẢM , NGUYỄN THẾ TÀI , NGUYỄN THÀNH ĐÔNG , VŨ THANH TÙNG , HOÀNG HỒNG HẢI , VŨ TOÀN THẮNG , NGUYỄN THỊ PHƯƠNG MAI
Published: November 2023

Ultrasonic vibration measurement and the development of ultrasonic vibration sensors have a significant impact on underwater pattern detection, providing good support for the exploitation and usage of marine resources. Advanced digital signal processing algorithms improve mechanical displacement measurements using ultrasonic speed and pm-level interferometers in real-time. In recent years, developing digital algorithms and employing low-cost software-defined radio (SDR) software applied to communication systems and other general-purpose systems with flexible solutions are essential in modern industrial applications. Specifically, the SDR can be consistent with real-time phase-change measurements of MHz-frequency interference signals for a heterodyne interferometer. This paper combines a heterodyne interferometer and a real-time SDR phase meter, demonstrating an ultrasonic vibration instrument's high-speed vibrating measurement capabilities. A double-pass interferometer is implemented to produce interference signals modulated with a sine waveform phase change associated with a tool's ultrasonic vibrating displacement, calculated by the phase meter's quadrature demodulation algorithm. The measurement results show that the system detects the sine-wave vibration trajectory generated by the vibrator at a frequency of 20 kHz and an amplitude of ~460 nm. The principle of the measurement system, instrumentations, experiments, and results are discussed in the paper.
Phân lập và tuyển chọn các dòng Bacillus Spp. có khả năng kiểm soát Vibrio Parahemolyticus gây bệnh hoại tử gan tụy ở tôm
Authors: Lê Thành Cường , Nguyễn Thị Anh Thư , Văn Hồng Cầm
Published: November 2023

Bệnh hoại tử gan tụy cấp tính (AHPND – acute hepatopancreatic necrosis disease) hay bệnh chết sớm (EMS) ở tôm gây ra bởi các chủng vi khuẩn Vibrio parahaemolyticus mang gen độc tố pirAB và làm thiệt hại nghiêm trọng cho ngành tôm nuôi toàn cầu. Sử dụng vi sinh vật có lợi thay thế kháng sinh được xem là một trong số biện pháp hiệu quả trong việc ngăn ngừa AHPND cho các hệ thống nuôi tôm hiện nay. Nghiên cứu hiện tại đã đánh giá tiềm năng làm chế phẩm sinh học đối kháng V. parahaemolyticus pirAB của 33 chủng Bacillus phân lập từ mẫu bùn rừng ngập mặn và tôm nuôi tại tỉnh Khánh Hòa. Trong số 9 chủng Bacillus có tính đối kháng, CCT-Ba9 và CCT-Ba42 tạo ra vạch đối kháng lớn nhất và có khả năng sinh enzyme ngoại bào tốt bao gồm cellulase, amylase, protease. Cả hai chủng đều được đánh giá an toàn khi cho thấy không có khả năng tan huyết. Kết quả định danh bằng đặc điểm sinh hóa và giải trình tự gen 16S rRNA xác định chúng lần lược là loài B. pumilus and B. subtilis. Cả 2 loài đều cho thấy phát triển tốt ở độ pH từ 4.0 đến 8.0 and độ mặn từ 0 đến 50‰. Kết quả của nghiên cứu cho thấy tiềm năng sử dụng Bacillus CCT-Ba9 và CCT-Ba42 để ngăn ngừa hoặc kiểm soát sự bùng phát của AHPND ở tôm nuôi.
Bdelovibrio BL1 có khả năng làm tan Vibrio Campbellii phát sáng phân lập từ tôm post nuôi
Authors: Nguyễn Thị Anh Thư , Văn Hồng Cầm , Lê Thành Cường
Published: November 2023

Bệnh phát sáng là một trong những bệnh gây thiệt hại nghiêm trọng cho ngành nuôi tôm, đặc biệt là trong giai đoạn ấu trùng. Bệnh do vi khuẩn phát sáng gây ra, và phổ biến hơn hết là do nhóm vi khuẩn Vibrios spp, trong đó Vibrio campbellii gây ra bệnh phát sáng có thể gây chết tôm với tỷ lệ cao. Nghiên cứu phân lập được 15 chủng phát sáng từ tôm thẻ và tôm sú giai đoạn ấu trùng nuôi ở Khánh Hòa, Ninh Thuận và Bình Thuận. Trong đó có 3 chủng vi khuẩn phát sáng V. campbellii (kí hiệu V1, V5 và V6) được định danh bằng cặp mồi chuyên biệt khuếch đại gen toxR cho chủng V. campbellii. Ngoài ra, chủng BALOs BL1 được phân lập từ ruột tôm thẻ khỏe mạnh được xác định thuộc chi Bdellovibrionaceae. Sau khi tiến hành thử nghiệm, BL1 có khả năng làm tan được chủng V1 và V6 trong môi trưởng lỏng sau 21 ngày và và trên đĩa thạch hai lớp sau 7 ngày. Nhưng chủng BL1 không làm tan được chủng V5. Kết quả nghiên cứu mở ra khả năng ứng dụng các chủng BALOs trong kiểm soát các vi khuẩn gây bệnh trong lĩnh vực nuôi trồng thủy sản.
Thu nhận và tính chất của collagen dạng vảy và dịch collagen thủy phân dịch thủy phân collagen từ vảy cá chẽm (Lates calcarifer)
Authors: Phan Thị Phượng , Trang Sĩ Trung , Nguyễn Văn Hòa
Published: November 2023

Collagen được sử dụng rộng rãi trong các ngành y dược, thực phẩm và mỹ phẩm. Tuy nhiên các nghiên cứu đã công bố chủ yếu chỉ tập trung vào thu nhận collagen dạng dịch thủy phân. Nghiên cứu này trình bày một quy trình mới thu nhận collagen dạng vảy, trước khi thủy phân thu dạng dịch từ vảy cá chẽm (Lates calcarifer). Kết quả phân tích cho thấy collagen dạng vảy có độ tinh sạch cao (hàm lượng khoáng < 1%). Phân tích phổ hồng ngoại các nhóm chức trong phân tử collagen không thay đổi sau quá trình thủy phân. Phân tích SDS-page đối với dịch thủy phân cho thấy trọng lượng phân tử của collagen thủy phân có khối lượng phân tử thấp (khoảng 10 kDa). Ngoài ra, phân tích thành phần collagen thủy phân cũng khẳng định sản phẩm có độ tinh khiết cao và chứa 17 acid amin. Từ những kết quả thu được ban đầu của nghiên cứu này cho thấy tiềm năng thu nhận collagen dạng vảy và dịch thủy phân có chất lượng tốt từ vảy cá chẽm nhằm ứng dụng trong các lĩnh vực như mỹ phẩm, thực phẩm và y dược.
Effect of Quality Control on Implementation of Construction Projects in Rwanda: A Case Study of Horizon Construction Ltd, Gikondo to Rebero Road (2019-2022)
Authors:   University of Kigali, Rwanda, Uwayishima Simeon
Published: November 2023

Since the 1987 World Commission on Environment and Development, project sustainability is increasingly becoming a critical element in project management. The increasing need for new project interventions means that donors are not prepared to keep investing scarce resources in the same projects for a long time, which calls for prioritization of sustainability throughout the project processes. This research project is based on a research project carried out in the horizon construction, focusing on effect of quality control in implementation of construction projects in Rwanda: the research has the following objectives: to find out factors consider in Plan qualities of project in horizon construction, to view the Perform quality assurance in monitoring and controlling of project, to view the Perform quality control help in executing of project. The researcher described the definition of key term and also usage of Project quality management, Competitive market and research used a sample size of 106 respondents from in horizon construction finance department and top management. The research was use questionnaires to collect data Then research conclude by saying that help in evaluating of the performance of business as well as certifying areas of improvement in horizon construction. Project quality management is performed to know the company Competitive market, investment profitability projections, and understanding the corporate financial position in terms of asset and liability comparisons from the balance sheet. Table presents the respondents opinion on reason of The visibility of the premise are checked to assure the availability of the premises, Rwanda with the mean of 4.42 percentage 93.4% Research findings also shows The major reason of quality control strategy in horizon construction are Perform Quality Assurance with mean of 4.43 at the average of 91.5%. Competitive market as dependent variable for this study is made during investment analysis to accept or reject a project by looking at reporting of the project management on profit and loss as well as calculate net present values of a project. Keywords: Quality Control, Implementation of Construction
DESIGN, CHARACTERIZATION AND EVALUATION OF NOVEL MUCOADHESIVE NASAL INSERTS FOR THE TREATMENT OF MIGRAINE
Authors:   NITTE (Deemed to be University), NGSM Institute of Pharmaceutical Sciences, Department of Pharmaceutics, Mangalore- 575 018, Karnataka, India, Amin Bindiya , Jose Jobin , Kumar Lalit
Published: November 2023

Recently, nasal administration has gained more attention as a safe way for delivering the active ingredients used to treat migraines. Strategies can be implemented by changing aspects like the medicines, delivery vehicle, and other components to get around the obstacles associated with conventional therapies. This research work aimed to explore the potential of lyophilized nasal inserts of eletriptan hydrobromide for the treatment of migraine attack. Here, the lyophilization technique is used for the nasal inserts preparation. The developed inserts were tested for various characterization studies,such as mucoadhesive examinations, water uptake, in vitro drug release, in vitro cytotoxicity, ex vivo investigations and stability. The inserts showed acceptable pH values, satisfactory mucoadhesion potential and excellent water uptake activity. In vitro release data for the formulations followed first-order kinetics. The cytotoxicity studies showed that there was a reduction in cell toxicity of drug embedded in the inserts when compared to the pure drug. When the prepared nasal inserts were used for treatment, there was no significant impact on the epithelium of nasal mucosa. The novel lyophilized nasal inserts of eletriptan hydrobromide could be a better alternative for the treatment of migraine
DRUG-CYCLODEXTRIN COMPLEXES: CURRENT STATUS AND RECENT ADVANCEMENTS
Authors:   Department of Pharmaceutical Sciences, H.N.B. Garhwal University (A Central University) Srinagar (Garhwal) - 246 174, Uttarakhand, India, S. Panwar Vikas , Adhikari Lokesh , Semalty Mona , Semalty Ajay
Published: November 2023

Cyclodextrins are water-soluble oligosaccharides formed by the action of cyclodextrin glucosyl transferase enzyme (CGTase) on the medium containing starch. Cyclodextrins are proven to be a cost-effective breakthrough in the pharmaceutical industry by formulating them with polymers and drugs to improve the safety, bioavailability, and solubility of APIs. This review describes the current status and advancement of cyclodextrin research in drug delivery. The use of cyclodextrins to improve the solubility and dissolution properties of poor water-soluble products has been reviewed exhaustively with a specific focus on their physicochemical property, practical methods, toxicity, the drug-cyclodextrin compatibility and its applications.
EXTRACTION AND ISOLATION OF Β-AMYRIN FROM FICUS ELASTICA
Authors:   Medicinal and Natural Products Research Laboratory, Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai – 400 019, Maharashtra, India, Nakkala Komalatha , Kulkarni Vrushali , S. Laddha Kirti
Published: November 2023

There is a huge interest in medicinally active constituents isolated from plants. β-Amyrin is a member of the class of pentacyclic triterpenoids and it is oleanane substituted at the 3 β-position by a hydroxyl group and containing a double bond between positions 12 and 13. These triterpenoids are generally found in many medicinal plants. The β-amyrin is generally extracted and isolated from leaves and oleoresin (latex) exudates by bark incisions of the plant sources from many plant species. The β-amyrin isolation described in this article was by a novel method developed for isolation. Triterpenoids are constituents that have shown a great interest in recent years due to their pharmacological potential, with numerous therapeutic activities, such as anticancer, anti-inflammatory, antiviral, antibacterial, antifungal, anti-diuretic, and acetylcholinesterase inhibitory. Due to the wide range of activities of β-amyrin, research has been undertaken to isolate it in a simple way. The isolated β-amyrin was characterized, and confirmed by multiple analytical methods.
SOLID DISPERSION SYSTEMS OF POORLY WATER SOLUBLE DRUG FEBUXOSTAT: PREPARATION, CHARACTERIZATION AND OPTIMIZATION
Authors:   Department of Pharmaceutics, PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda -403 401, Goa, India, N. Deshpande Mangirish , S. Dessai Shruti , Dighe Pearl
Published: November 2023

Febuxostat is a poor soluble drug used in the management of hyperuricemia and gout. The present study aims at increasing the solubility of febuxostat by solid dispersion technique with the aid of various polymers (Beta cyclodextrin, Soluplus®, HPMC E5, and Kolliphor® P 407) in various drug: carrier ratios employing the solvent evaporation method. Solid dispersions were evaluated for physical appearance, percentage yield, drug content, saturation solubility and dissolution properties. Saturation solubility data of the study depict an increased solubility of the solid dispersion compared to the pure drug. In in vitro release profiles revealed that formulation SD20, having drug: Kolliphor® P 407 in 1:9 ratio exhibited highest dissolution rate. The powder X-ray diffraction study and scanning electron microscopy (SEM) exhibited a crystalline to an amorphous transformation in the solid dispersion. The study demonstrated that solid dispersions are a highly effective technique to increase solubility and bioavailability of febuxostat.