bluuebunny/crossref_metadata_2025 huggingface dataset:
Penggunaan Media Gambar Berbasis Kepedulian Lingkungan Sebagai Pengembangan Bahan Ajar Teks Deskripsi Dengan Menggunakan Metode Think Talk Write Untuk Tingkat SMP Di Kota Semarang
Authors: Afif Muhammad Asyhar , . Asropah , . Suwandi
Published: February 2022

ABSTRACTThis research was conducted using the Research and Development (R&D) method adopted from Sugiyono which includes the following steps: 1) Preliminary Study, namely literature study and field study, 2). Development Studies, including: (1) initial product design, (2) design corrections from experts, (3) design revisions, (4) limited trials, (5) Focus Group Discussions (FGD), and (6) product revisions .The results of the expert / expert validation assessment show that the overall percentage obtained is 84.4% or if converted into criteria or categories gets the predicate worthy of being tested. After being validated, the learning media was tried out in the school under study and got the grade IV teacher's assessment in the two schools, the results were that the feasibility of presenting learning media for teachers got a score of 94%, while the results of student responses got a score of 95.7%, if converted into criteria or the category gets the predicate worthy.From the data above, it can be concluded that the developed teaching materials are categorized as suitable for use in learning activities. Use of Image Media Based on Environmental Concern for the Development of Teaching Materials Text Description Using the Think Talk Write Method can provide a fun new atmosphere for students so that students are motivated to participate in learning activities. Keywoards: Teaching Materials, Media, Pictures, Environmental Concern, TTW
O estresse médico frente às constantes mudanças das condições de trabalho tendo a fenomenologia como fonte de abertura para a profissão no contemporâneo
Authors: TEIXEIRA PETERSON GONCALVES , Quintino Amaro Sebastiao de Souza , Ferreira Daniel Fonseca , Nascimento Crisóstomo Lima do
Published: February 2022

RESUMO
O trabalho médico é fonte de discussão através dos tempos, principalmente quanto ao desenvolvimento tecnológico junto à ação do profissional frente às mudanças nas formas de atendimento e dos p
CNFMD: Convolutional Network-based Face Mask Detection
Authors: Saksham Checker
Published: February 2022

After the rise of the coronavirus, every country has made a compulsion on wearing face masks in public places. Even though a few countries have reached a good number of vaccinations to date, the human body is still not immune to the new variants of the virus. It will take a few more years till everyone becomes mask-free. Thus, authorities need a system to keep a proper check on the discipline whether everyone is wearing a mask in a public place or not. This paper proposes a model with 99.5% accuracy which can be deployed and thus can monitor public places. This will help the authorities to control the spread of the virus. The model proposed is a fast model which took only 38.03 seconds on average per epoch while training. Using the Kaggle dataset, the CNFMD model is trained and tested. The dataset, pre-split into three parts is used from training, validation as well as testing of the model.
THE EFFECT OF EARNING VOLATILITY, INCOME SMOOTHING AND EARNING PERSISTENCE ON EARNINGS QUALITY
Authors: Sasongko Yoga Joko , Azizah Siti Nur , Wahyuni Sri , Hapsari Ira
Published: February 2022

This study aims to examine the effect of earnings volatility, smoothing earnings and earningspersistence. The independent variables used in this study are earnings volatility, income smoothingand earnings persistence. The dependent variable used in this study is earnings quality. Themethod uses secondary data in annual reports or financial reports that have been published byIslamic banking companies listed on the Indonesia Stock Exchange for the period 2016-2019. Thesampling technique used in this study was purposive sampling, while the analysis used in this studywas multiple regression. The results of hypothesis testing showed that earnings volatility has apositive effect on earnings quality. Income smoothing has a positive effect on earnings quality.Earnings persistence does not affect earnings quality
EFEKTIFITAS PENGGUNAAN STANDAR AKUNTANSI KEUANGAN ENTITAS MIKRO KECIL DAN MENENGAH (SAK EMKM) PADA USAHA MENENGAH
Authors: Sulistiyowati Iis , Yusuf Ayus Ahmad , Purnama Dendi
Published: February 2022

This study examines the effect of Education Level, Accounting Understanding, and Business Experience on the Effectiveness of Using Financial Accounting Standards for Micro, Small, and Medium Entities (SAK EMKM) in Medium Enterprises in Kuningan Regency. This research was conducted using descriptive and verification methods. The population is all owners and employees of the finance section of medium-sized businesses in Kuningan Regency, totaling 86 respondents. Samples were taken as many as 86 respondents using a Saturated Sample, where the respondent sample was taken entirely. The data collection technique used a questionnaire with data analysis tools in multiple linear regression analysis. The results of this study indicate that the level of education, accounting understanding, and business experience have a simultaneous and significant effect on the effectiveness of using SAK EMKM in medium-sized businesses. Education level has a significant positive effect on the effectiveness of using SAK EMKM in medium-sized businesses. Accounting understanding has a significant positive effect on the effectiveness of using SAK. EMKM in medium-sized businesses and business experience significantly affect the effectiveness of using SAK EMKM in medium-sized businesses.
DAMPAK KEBIJAKAN RESTRUKTURISASI KREDIT DI MASA PANDEMI COVID-19 TERHADAP KINERJA PERBANKAN DI INDONESIA
Authors: Rimbawan Teguh
Published: February 2022

Penelitian ini bertujuan untuk mengetahui dampak penerapan kebijakan restrukturisasi kredit di masa pandemi COVID-19 terhadap kinerja keuangan perbankan di Indonesia. Restrukturisasi kredit di masa pendemi COVID-19 merupakan pelaksanaan Peraturan Otoritas Jasa Keuangan Republik Indonesia Nomor 11/POJK.03/2020 tentang Stimulus Perekonomian Nasional Sebagai Kebijakan Countercyclical Dampak Penyebaran COVID-19 (Otoritas Jasa Keuangan, 2020). Populasi penelitian yaitu seluruh bank terdaftar di Otoritas Jasa Keuangan (OJK). Pemilihan sample menggunakan metode purposive sampling untuk laporan keuangan bank yang diterbitkan tahun 2019 dan tahun 2020. Penelitian ini menggunakan Uji Wilcoxon untuk mengukur seberapa besar perbedaan kinerja keuangan perbankan sebelum dan sesudah diumumkannya pemberlakuan POJK No.11 tahun 2020. Kinerja keuangan bank diukur menggunakan Tingkat Kesehatan Bank dengan pendekatan Risiko (Risk-based Bank Rating/RBBR) yaitu Good Corporate Governance (GCG), Profil risiko (risk profile) diukur menggunakan rasio Non Performing Loan/Financing (NPL/NPF) dan Loan/Financing to Deposit Ratio (LDR/FDR), Rentabilitas (earnings) diukur menggunkan rasio Return of Assets (ROA), serta Permodalan (capital) menggunakan rasio Capital Addequacy Ratio (CAR). Hasil penelitian dapat disimpulkan bahwa kinerja keuangan perbankan berdasar NPL/NPF tidak ada perbedaan sebelum dan sesudah penerapan kebijakan restrukturisasi kredit di masa pandemi COVID-19, sedangkan untuk LDR/FDR, ROA, dan CAR ada perbedaan.
LIKUIDITAS, SOLVABILITAS DAN PROFITABILITAS TERHADAP HARGA SAHAM
Authors: Candera Mister , Pradana Ario Daffa Aji , Kosim Belliwati
Published: February 2022

Penelitian ini bertujuan untuk mengetahui Pengaruh Likuiditas, Solvabilitas, Profitabilitas Terhadap Harga Saham pada perusahaan LQ45 yang Terdaftar Di Bursa Efek Indonesia. Penarikan sampel menggunakan non probability sampling dengan metode purposive sampling, sampel yang digunakan adalah 17 perusahaan. Data yang diperlukan adalah data sekunder yang di peroleh dari Bursa Efek Indonesia melalui situs www.idx.co.id dan metode pengumpulan data yaitu mengunakan metode dokumentasi. Teknik analisis yang digunakan dalam penelitian adalah tenik analisis linier berganda, uji asumsi klasik dan uji hipotesis. Hasil penelitian dari regresi linier berganda Y =( 4.166 – 0.379 X1 – 0.326  X2 + 0,204 X3 +e), uji F (Uji Simultan) dengan Fhitung sebesar 5.353 > Ftabel 2.716 atau Signifikan sebesar F 0,002 < 0,05 artinya ada pengaruh antara Likuiditas, Solvabilitas, Aktivitas, Profitabilitas secara bersama – sama terhadap harga saham dan uji t (Uji Parsial) pada Likuiditas thitung sebesar -2,171< ttabel sebesar 1,989 dan Signifikan Likuiditas 0,033 < 0,05 dengan demikian dapat disimpulkan bahwa Likuiditas mempunyai pengaruh yang signifikan terhadap harga saham, pada Solvabilitas thitung sebesar -2,570 < ttabel sebesar 1,989 dan Signifikan Solvabilitas 0,012 < 0,05 dengan demikian dapat disimpulkan bahwa Solvabilitas mempunyai pengaruh yang signifikan terhadap harga saham, pada Profitabilitas thitung sebesar 1,513 < ttabel sebesar 1,989 dan Signifikan Profitabilitas 0,134 > 0,05 dengan demikian dapat disimpulkan bahwa Profitabilitas tidak mempunyai pengaruh yang signifikan terhadap harga saham
PENGARUH TAX AVOIDANCE, UKURAN PERUSAHAAN, DAN PROFITABILITAS TERHADAP NILAI PERUSAHAAN DENGAN ASEAN CORPORATE GOVERNANCE SCORECARD SEBAGAI VARIABEL MODERASI
Authors: Qushoyyi Muhammad Ahnaf Ammar , Khabib Suryo Nur
Published: February 2022

ABSTRAK Penelitian ini dilatar belakangi oleh menariknya nilai perusahaan karena menggambarkan kondisi perusahaan yang dapat mempengaruhi pandangan investor terhadap perusahaan. Tingginya kemakmuran pemegang saham bisa dilihat dari nilai perusahaan. Pada awalnya perusahaan didirikan dengan tujuan untuk memaksimalkan kekayaan pemilik atau pemegang saham. Meningkatkan nilai perusahaan mempunyai arti meningkatkan pendapatan dan menimalisir biaya yang keluar dengan tujuan menghasilkan laba yang maksimal. Tujuan penelitin ini untuk mengetahui pengaruh tax avoidance, ukuran perusahaan, dan profitabiltas terhadap niali perusahaan dengan ASEAN corporate governance scorecard sebagai variabel moderating pada perusahaan lq 45 pada tahun 2018-2020. Metode pengumpulan data penelitian dengan ini menggunakan data sekunder berasal dari Annual Report perusahaan anggota rutin lq 45 pada tahun 2018-2020. Hasil penelitian variabel tax avoidance dan uuran perusahaan tidak mempengaruhi nilai perusahaan, sedangkan profitabilitas mempengaruhi nilai perusahaan. Kemudian, tax avoidance terhadap nilai perusahaan dan ukuran perusahaan terhadap nilai perusahaan tidak mampu dimoderasi ASEAN corporate governance scorecard, sedangkan profitabilitas terhadap nilai perusahaan mampu dimoderasi ASEAN corporate governance scorecard.
Pengaruh Sponsorship dan Brand Ambassador terhadap Purchase Intention dengan Brand Image sebagai Variabel Intervening (Studi pada Shopee sebagai Sponsor Utama Liga 1 Indonesia dan Cristiano Ronaldo sebagai Brand Ambassador)
Authors: Alinda Diza Nur , Herman Herman , Hambalah Febrina
Published: February 2022

This study aims to determine the effect of sponsorship and brand ambassador on purchase intention with brand image as an intervening variable at Shopee as the Main Sponsor of Liga 1 Indonesia and Cristiano Ronaldo as a Brand Ambassador. The method used in this research is quantitative research with explanatory research type. The research was conducted on residents of eastern Surabaya with the criteria that they have never purchased Shopee, know the Shopee League 1 football match, and know Cristano Ronaldo as Shopee's Brand Ambassador with a total of 90 research respondents. The sampling technique for nonprobability sampling was purposive sampling technique and used sample size guidelines according to Hair et al (2014). The data collection technique used a questionnaire using the Structural Equation Modeling (SEM) data analysis technique with the student version of the SmartPLS 3.2.7 analysis tool. The results of this study indicate that: 1. Sponsorship affects Purchase Intention 2. Brand Ambassador does not affect Purchase Intention 3. Sponsorship does not affect Brand Image 4. Brand Ambassador affects Brand Image 5. Brand Image affects Purchase Intention. 6. Brand Image as an integration variable does not indirectly affect the relationship of Sponsorship and Purchase Intention 7. Brand Image as an integration variable indirectly affects the relationship between Brand Ambassador and Purchase Intention.
Viraler Angriff auf fragile Subjekte
Authors: Bossert Florian
Published: February 2022

Die COVID-19-Pandemie ist Ausdruck einer umfassenden ökologischen und gesellschaftlichen Krise – hervorgerufen durch den menschlichen Drang zur Beherrschung der Natur. Vor diesem Hintergrund untersucht Florian Bossert die Auswirkungen der pandemischen Realität auf die menschliche Denkfähigkeit. Er versteht das Virus als unheimliches Objekt, das das Subjekt zunächst von außen bedroht, als Fremdkörper jedoch zunehmend ins Innere eindringt und sowohl Ängste freisetzt als auch Abwehrmechanismen reaktiviert. So entwirft Bossert einen umfassenden Blick auf die pandemische Gegenwart: Globale Krisen, unbewusste Fantasien, archaische Ängste und Verschwörungsdenken werden im Rückgriff auf Kritische Theorie und Psychoanalyse fruchtbar zusammengedacht, wodurch sich nicht zuletzt Möglichkeiten eröffnen, wie die Gesellschaft mit der Krise umgehen kann.
Arquitectura troglodita en las Islas Canarias. El Caso de la Palma. Alternativas para su revitalización
Authors: Cabrera García Víctor Manuel , Santana Rodríguez Ricardo Javier
Published: February 2022

Los variados elementos de la arquitectura troglodita de la isla de La Palma se han ido abandonando gradualmente por sus usuarios en busca de unas mejores condiciones de vida. La falta de uso, el aislamiento geográfico, las elevadas pendientes de los caminos de acceso, así como la escasa protección de estos ante los desprendimientos del terreno han propiciado que no se realicen las debidas tareas de mantenimiento y, por tanto, el estado de conservación es deficiente. Ante la inevitable degradación que presenta la arquitectura excavada de la Isla se plantea la necesidad de revitalizar dicho Patrimonio Cultural mediante la incorporación de nuevos usos que sean compatibles con estos espacios excavados con la finalidad de devolverles algunos de los valores que han perdido con el paso del tiempo y para que puedan convertirse en un reclamo tanto para los lugareños como para los visitantes. Por lo tanto, es necesario encontrar un equilibrio entre el aprovechamiento social y económico incorporando medidas orientadas a la mejora de la calidad de vida de las personas que nos permitan recuperar un modo de vida sostenible y compatible con la naturaleza aprovechando los recursos naturales presentes en cada localidad.
ANALISIS KUALITAS PRODUK FURNITURE DENGAN PENDEKATAN METODE SIX SIGMA
Authors: Izza Ainul , Retnowati Dini
Published: February 2022

Kualitas menjadi prioritas utama yang harus dijaga karena menjadi salah satu alasan utama yang mempengaruhi keputusan pembelian dan loyalitas pelanggan. PT. MMI sebagai salah satu perusahaan furniture masih memiliki permasalahan dalam pengendalian kualitas untuk produk kursi. Pendekatan metode six sigma dalam lima tahapan  yaitu DMAIC (Define, Measure, Analyze, Improve, Control) digunakan dalam penelitian ini. Dari hasil pengolahan data di tahap measure diperoleh nilai DMPO sebesar 25830,9 dengan level sigma 3,46. Sedangkan dari tahap analyze diperoleh informasi bahwa ada tiga jenis cacat yang menjadi prioritas analisis untuk masuk ke dalam tahapan pembuatan diagram fishbone dan FMEA. Ketiga jenis cacat tersebut adalah jenis cacat kayu retak atau kayu pecah, jenis cacat warna tidak standar dan jenis cacat baret atau depos. Dari hasil FMEA, faktor yang memiliki nilai risk priority number tertinggi yang akan terlebih dahulu diperbaiki.
Pengaruh Purifikasi Terhadap Kandungan Zat Aktif dan Aktivitas Antioksidan Ekstrak Etanol 50% Daun Kelor (Moringa oleifera L.)
Authors: Purwanto Diyan Sakti , Susanti Hari , Sugihartini Nining
Published: February 2022

Purifikasi ekstrak etanol 50% daun kelor (Moringa oleifera L.) dilakukan untuk meningkatkan kandungan zat aktif flavanoid, β-karoten, saponin dan tanin yang memiliki aktivitas sebagai antioksidan. Tujuan penelitian ini adalah mengetahui jenis pelarut yang paling optimal antara etil asetat dan n-heksan dalam fraksinasi ekstrak etanol 50% daun kelor.

Penelitian dimulai ekstraksi etanol 50% daun kelor dengan maserasi dan dilanjutkan evaporator kemudian waterbath sampai diperoleh ekstrak kental. Ekstrak kental yang diperoleh dari ekstraksi selanjutnya dilakukan purifikasi. Fraksinasi dengan melarutkan ekstrak kental etanol 50% daun kelor (E1) dan aquades pada suhu 70ºC kemudian ditambahkan etil asetat pada corong pisah hingga di peroleh fraksi etil asetat (E2), ekstrak kental etanol 50% daun kelor (E1) ditambahkan n-heksan pada corong pisah hingga terjadi pemisahan fase sehingga diperoleh fraksi n-heksana (E3). Ekstrak dan fraksi dievaluasi parameter meliputi kadar air ekstrak dengan gravimetri, kadar β-karoten dengan HPLC dan aktivitas antioksidan dengan DPPH. Data dianalisis statistik dengan taraf kepercayaam 95%.

Hasil Penelitian menunjukkan bahwa kadar air ekstrak etanol 50% daun kelor adalah 4,16 dengan CV 4,62%. Kadar β-karoten paling optimal pada fraksi n-heksana (E3) kemudian etil asetat (E2) dan etanol 50% (E1) yaitu 1.48 ± 0.01%, 1.19 ± 005% dan 0.73 ± 0.01%. Sedangkan aktivitas antioksidan (IC50) paling optimal pada fraksi n-heksana (E3) kemudian etanol 50% (E1)  dan etil asetat (E2) yaitu 40.83 ± 0.04 ug/ml, 47.75 ± 0.09 ug/ml dan 58.79 ± 0.10ug/ml. Nilai aktivitas antioksian menunjukkan pada fraksi n-heksana  dan ekstrak etanol 50% termasuk dalam kategori sangat kuat sedangkan fraksi etil asetat termasuk dalam kategori kuat sehingga berpotensi sebagai antioksidan.
Immunological aspects of ovarian malignancy
Authors: Martins-Filho Agrimaldo , Jammal Millena Prata , Candido
						Murta Eddie Fernando , Nomelini Rosekeila Simões
Published: February 2022

Objective: Evidence shows that the host’s immune system interacts with tumor development and may be responsible for delaying tumor growth or even for its progression. Chronic inflammation has been identified as a key factor in the pathogenesis of ovarian cancer. The objective of this study is to carry out a comprehensive review of immunological aspects of ovarian cancer. Mechanism: A search of the following keywords was conducted in the PubMed database: “ovarian cancer”, “prognostic factors”, “immunotherapy”, “immune system”. The articles identified were published between 1992 and 2021. Findings in brief: A total of 75 articles were selected for further examination. Conclusions: The understanding of tumor immune escape mechanisms will improve immunotherapy treatments. This will allow personalization or treatment not only in accordance with the biology of the tumor, but also with the characteristics of the tumor microenvironment, expanding the benefit of immunotherapy and providing more effective responses.
Clinical data analysis of nine years of experience with twin pregnancy: a tertiary hospital-based retrospective study
Authors: Ting Yuan , Ting Zhang , Yan-Yan Wang , Xue-Lan Li , Zhen Han
Published: February 2022

Background: The incidence of twin pregnancy has been increasing worldwide and in China. This study provided a comprehensive analysis of the clinical data of twins in a Chinese tertiary hospital and summarized the clinical characteristics. Methods: A retrospective collection of data was carried out for 717 cases of twins in the Obstetrics Department of the First Affiliated Hospital of Xi’an Jiaotong University from 2011 to 2020. A comprehensive analysis of baseline information and maternal and perinatal outcomes was conducted, and the twin birth rate of the study population was also calculated. Results: The average twin delivery rate was 2.61%. A total of 206 cases were monochorionic, and 511 cases were dichorionic. Premature delivery, hypertensive disorder complicating pregnancy and premature rupture of membranes were the three most common complications. Caesarean section rates from 2011 to 2019 were maintained at 70%–80%. A total of 144 cases (20.08%) of 717 twin cases were complicated twins. Birthweight discordance ≥25% accounted for 13.53% of cases. Adverse neonatal outcomes with higher incidences were neonatal respiratory distress syndrome, small for gestational age and 1 min Apgar score ≤7. Conclusions: Twin pregnancy has different and unique clinical features. Obstetricians should pay close attention to its clinical management to obtain better perinatal outcomes.
Impact of Urinary Incontinence on Women’s Sexuality
Authors: Escura Sancho Sílvia , Ribera-Torres Laura , Castelo-Branco Camil , Anglès-Acedo Sònia
Published: February 2022

Objective: Globally, the prevalence of urinary incontinence (UI) in women is estimated to be in the range of 25% to 45%. Different types of UI exist, being the most frequent ones stress UI, urgency UI and mixed UI. Being affected by UI is associated with a higher risk of sexual inactivity, regardless of its type. Mechanism: It is estimated that 5–38% patients with UI are sexually inactive due to UI, whereas 25–38% sexually active women would restrict their sexual activity due to UI. The prevalence of sexual dysfunction within sexually active women with UI is 23–56%. Findings in Brief: In patients with UI, the most frequent sexual dysfunctions are dyspareunia (44%), female sexual interest/arousal disorder (34%) and orgasmic disorder (11%). Therefore, UI has a negative impact on the sexual function of sexually active women with UI. Coital incontinence is defined as the complaint of involuntary loss of urine during or after intercourse. UI with penetration represents any complaint of involuntary loss of urine with vaginal stimulation (either with a sexual toy, manually or with penetration). Orgasmic UI refers to any complaint of involuntary loss of urine occurring at orgasm, regardless of the sexual behaviour that has triggered it. Due to the high prevalence of coital UI (50–60%) in the female population and its strongly negative impact on women’s sexuality, patients should be specifically asked for coital UI in the gynecologic visits. Conclusions: UI affects between one in four and one in two women and had a negative impact on quality of life. Not only UI has an impact on female sexuality, but also different treatments which are offered to treat it can play a role. The reduction of sexual problems with pelvic floor muscle training in women with stress UI has been proved, being the rate of sexual activity doubled. A significant improvement of the overactive bladder associated to urgency UI and female sexual function has been described after the pharmacological treatment or botulinum toxin. Finally, significant improvement of the sexual function has also been found after midurethral slings for stress UI, as well as for coital UI.
Regulation of macrophage-associated inflammatory responses by species-specific lactoferricin peptides
Authors: Malone Alicia , Clark Rikki F. , Hoskin David W. , Power Coombs Melanie R.
Published: February 2022

Background: Inflammation is the body’s response to injury or infection and is important for healing and eliminating pathogens; however, prolonged inflammation is damaging and may lead to the development of chronic inflammatory disorders. Recently, there has been interest in exploiting antimicrobial peptides (AMPs) that exhibit immunoregulatory activities to treat inflammatory diseases. Methods: In this study, we investigated the immunomodulatory effects of lactoferrin-derived lactoferricin AMPs from three different species (bovine, mouse, and human) with subtle differences in their amino acid sequences that alter their antimicrobial action; to our knowledge, no other studies have compared their immunomodulatory effects. Macrophages, key players in the induction and propagation of inflammation, were used to investigate the effects of species-specific lactoferricin peptides on inflammatory processes. Results: Bovine lactoferricin was the only one of the three peptides studied that downregulated lipopolysaccharide (LPS)-induced pro-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-6, in both human and mouse macrophages. Lactoferricin regulated inflammation through targeting LPS-activated nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) signaling pathways. Although the immunoregulatory role of lactoferricin during an inflammatory response in vivo is yet to be elucidated, further investigation with the use of animal models is warranted by the current findings. Conclusions: The ability of lactoferricin, especially that of bovine origin, to downregulate macrophage-mediated inflammatory responses suggests potential for the development of this peptide as a novel immunotherapeutic agent in the treatment of chronic inflammatory conditions.
Circadian rhythms in thrombosis and atherothrombotic events
Authors: Peñaloza-Martínez Eduardo , Moreno Guillermo , Aroca-Crevillén Alejandra , Huertas Sergio , Vicent Lourdes , Rosillo Nicolás , Hidalgo Andrés , Bueno Héctor
Published: February 2022

Biological circadian rhythms in living organisms are regulated by molecular clocks. Several of these clocks are present in blood vessels, peripheral tissues, and immune cells. There is strong evidence linking dysregulation of circadian rhythms to the development of cardiovascular disease. Dysregulation of circadian rhythms is believed to activate inflammatory processes at specific times of day, leading to an increased risk of thrombosis and atherosclerosis progression. Research into circadian clock genes and molecular networks has the potential to identify therapeutic targets to reduce cardiovascular risk. In this review, we summarize the evidence linking circadian rhythms to thrombosis and atherothrombotic events and discuss potential therapeutic implications.
Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review
Authors: Kababie-Ameo Rebeca , Rabadán-Chávez Griselda Mericia , Vázquez-Manjarrez Natalia , Gutiérrez-Salmeán Gabriela
Published: February 2022

Diabetes Mellitus is a highly prevalent disease in Mexico and in the world, among whose complications is diabetic neuropathy. DN is a group of disorders that present signs and/or symptoms of peripheral nerve dysfunction and have different clinical manifestations in both peripheral neuropathy and autonomic neuropathy. As a part of the mechanisms by which DN develops, oxidative stress and inflammation have been described. Cocoa is a plant origin product which includes around 300 components and through different studies, it has been suggested that cocoa has different mechanisms of action through which exerts its beneficial effects on health. It has been proposed that cocoa has hypoglycemic, lipid-lowering, antioxidant and anti-inflammatory effects, and thus, potentially have a beneficial direct or indirect effect on diabetic neuropathy. Specially in preclinical studies, the anti-inflammatory and anti-nociceptive effect of cocoa has been evaluated through different mechanisms of action. However, most of the studies presented concerning this complication, are in vitro or preclinical studies, so there is still a great area of opportunity regarding the use of cocoa on diabetic neuropathy.
A new injury severity scale for ocular complications following cosmetic filler injection
Authors: Si Shancheng , Lai Linying , Ding Xue , Su Wei , Zhou Guiwen , Wang Qihua , Wang Lei , Ji Yicong , Chen Anming , Yu Youtao , Chen Minliang , Hu Yuntao
Published: February 2022

Background: Cosmetic filler injection can cause a variety of eye complications; however, there is currently no good way to evaluate injury severity and prognosis. By analyzing the injury manifestations of severe ocular complications following cosmetic filler injection and their prognosis, we propose a new injury severity scale. Methods: Twenty-two eyes of 22 patients experiencing ocular complications following cosmetic filler injection were followed for 6 months to observe injury characteristics, manifestations and prognosis. Best corrected visual acuity (BCVA), intraocular pressure (IOP), split lamp microscopy, fundus photography, optical coherence tomography (OCT), and fundus fluorescein angiography were examined at the onset and follow-up visits. Results: According to the immediate BCVA at the time of injury (with the presence or absence of brain infarction), a new injury severity scale was proposed, namely, Grades 1–4. Grade 1 (4 patients) and Grade 2 (2 patients) tended to have no atrophy of the globe. Grade 3 (12 patients) and Grade 4 (4 patients) were more likely to develop atrophy of the globe (4/12 patients and 2/4 patients, respectively) at the last follow-up. Grade 3 and Grade 4 were more likely to be complicated with ophthalmoplegia and ptosis (7/16 patients). Conclusions: The new injury severity scale we proposed can determine the prognosis of different ocular complications following cosmetic filler injection. Accordingly, we can inform injured patients regarding the possibility of phthisis bulbi and the extent of improvement of visual impairment, ophthalmoplegia, ptosis and stroke.
Prognostic value of protein tyrosine kinase 6 overexpression in cancers: a meta-analysis
Authors: Jeong Soo Young , Kim Jung Han , Lee Jae-Jun , Park Sung Taek , Kim Hyeong Su
Published: February 2022

Background: Protein tyrosine kinase 6 (PTK6) plays an important role in cell proliferation and differentiation. However, the functions of PTK6 appear highly context-dependent and differ depending on the cell type, as well as its intracellular localization. High PTK6 expression in tumor has been associated with poor pathological features and prognosis in some studies, but other studies have reported opposite results. Therefore, we performed this meta-analysis to derive more precise estimations of the association of PTK6 expression with prognosis and clinicopathological features in cancer patients. Methods: We conducted a literature search in PubMed, Ovid MEDLINE, and MEDLINE databases to cover all articles published until June 2021. All 1475 patients from the eight studies were included in the meta-analysis. Because of heterogeneity in PTK6 expression in non-tumor tissues, the included studies were divided into two subgroups according to PTK expression in non-tumor tissues: the low expression subgroup (LESG) or high expression subgroup (HESG). Results: Patients with high PTK expression showed significantly worse overall survival (OS) in LESG (Hazard Ratio (HR) = 2.53 [95% Confidence Interval (CI), 1.68–3.83], p < 0.0001), but significantly better OS in HESG (HR = 0.56 [95% CI, 0.40–0.78], p = 0.0006). PTK6 expression also showed different associations with clinicopathological features, such as advanced T classification, stage, and differentiation according to PTK6 expression in non-tumor tissues. Conclusions: PTK6 expression in tumor was a prognostic factor in patients with various cancers, but the direction of prognosis differs, depending on the degree of PTK6 expression in non-tumor tissues.
Advancements in 3WJ-based RNA nanotechnology and its application for cancer diagnosis and therapy
Authors: Liu Xin , Duan Dihan , Wang Yi , Liu Jian , Duan Demin
Published: February 2022

Background: This attractive and intriguing Ribonucleic acid (RNA) nanotechnology has been conceptualized over the last two decades and with our increasing understanding of RNA structure and function and improvements of RNA nanotechnology it is now possible to use this in clinical settings. Methods: Here we review the unique properties and the recent advances in RNA nanotechnology and then look at its scientific and preclinical applications for tumor diagnosis and targeted delivery and RNA-based therapy using RNA nanoparticles with diverse structures and functions. Finally, we discuss the future perspectives and challenges to RNA nanotechnology. Results: RNA can be designed and manipulated in a similar way to DNA while having different rules for base-pairing and displaying functions similar to proteins. Rationally designed RNA nanoparticles based on the three-way junction (3WJ) motif as the core scaffold have been extensively explored in the field of nanomedicine and targeted cancer diagnosis and therapy. Conclusions: RNA nanostructures based on 3WJs demonstrate promising future applications due to their thermal stability, molecular-level plasticity, multifunctional chemotherapeutic drug delivery and other intrinsic characteristics, which will greatly improve the treatment of cancer and promote further major breakthroughs in this field.
Effect of Low-Level Er: YAG (2940 nm) laser irradiation on the photobiomodulation of mitogen-activated protein kinase cellular signaling pathway of rodent cementoblasts
Authors: Yong Jiawen , Li Pingping , Mizrahi Isaac Kably , Franzen Rene , Groeger Sabine , Ruf Sabine , Gutknecht Norbert , Marques Márcia Martins
Published: February 2022

Backgrounds: Dental avulsion due to trauma, especially in young patients, is a worldwide problem, requiring tooth replacement. Delayed replantation could cause tooth loss when the cementum is severely damaged. A small number of studies has reported that photobiomodulation (PBM) therapy using Er: YAG laser irradiation activates cellular signaling responses in different cell types, resulting in a variety of favorable biological effects. The aim of this in vitro study was to evaluate the potential biostimulatory effect of low-level Er: YAG laser irradiation on the biological responses of cultured mouse cementoblasts (OCCM-30), including the mitogen-activated protein kinases (MAPKs). Methods: OCCM-30 cells were exposed to 2940 nm Er: YAG laser irradiation for 15 s at 0.34 W (pulse duration of 100 or 1000 μs, 17 mJ/pulse) at energy densities of 1 or 2 J/cm2. Irradiated and non-irradiated OCCM-30 cells were tested for migration (Scratch assay), proliferation (MTS assay) and functional differentiation (Alizarin Red S assay). Lumican (Lum) and Fibromodulin (Fmod) gene expression, and activation of MAPKs, were assessed by RT-PCR and Western blotting, respectively. Results: Low-level Er: YAG laser irradiation at 2 J/cm2 and pulse duration of 1000 μs resulted in the highest migration rate and proliferation. Moreover, the pulse duration irradiation of 100 μs increased Lum expression. Fmod expression was increased after 1000 μs pulse duration laser stimulation. Low-level Er: YAG laser irradiation increased the mineralization of OCCM-30 cells after 7 days and activated ERK1/2, P38 and JNK signaling. Conclusions: Low-level Er: YAG laser irradiation induces OCCM-30 cell migration, proliferation and differentiation, and activates the MAPK signaling pathway.
Variants of SARS CoV-2: mutations, transmissibility, virulence, drug resistance, and antibody/vaccine sensitivity
Authors: Prüβ Birgit M.
Published: February 2022

Severe acute respiratory syndrom coronavirus-2 (SARS CoV-2) is the causative agent of coronavirus disease-19 (Covid-19) which has been designated a worldwide pandemic by the World Health Organization on March 11, 2020. Since that time, the virus has mutated and an assortment of variants have been successful at establishing themselves in the human population. This review article describes the SARS CoV-2 genome, hot spot mutations, variants, and then focuses on the Delta variant, finishing up with an update on the Omicron variant. The genome encompasses 11 open reading frames, one of which encodes the spike or S protein that has been the target for vaccines and some of the drugs because of its role in attachment to the human host cell, as well as antibodies. Mutations in the S protein that are common among several of the variants include D614G that increases transmissibility and viral load and is often associated with P323L on the RNA dependent RNA polymerase. N501Y is a mutation in the receptor binding domain of the S protein that increases binding to the ACE-2 receptor on the human host cells by 10 fold. The discussed variants carry combinations of these and other mutations and are classified by the World Health Organization as variants of concern, variants of interest, and variants under monitoring. All variants are characterized by increased transmissibility (relative to the original SARS CoV-2), which is the reason for their ability to establish themselves. Several but not all variants are more resistant to antiviral drugs and less susceptible to antibodies/vaccines. The Delta variant that dominated the world until November 2021 causes an increased risk for hospitalization and death, but is still very susceptible to the current vaccines. The most recent variant, Omicron, is characterized by increased transmissibility and decreased antibody susceptibility.
Drug-coated balloon for the management of coronary chronic total occlusions
Authors: Sanchez-Jimenez Erick , El-Mokdad Rami , Chaddad Rima , Cortese Bernardo
Published: February 2022

There is a higher rate of successful recanalization of patients with coronary chronic total occlusions, nevertheless, the rate of patients referred for revascularization remains low. In addition, there is a greater need to improve long-term outcomes of chronic total occlusions after percutaneous coronary intervention, and although the implantation of new-generation drug-eluting stents has been optimized with coronary imaging guidance, the rate of stenting failure remains a major issue and long-term vessel patency could be improved. We reviewed clinical data regarding the benefit of treating chronic total occlusions and the use of drug-coated balloons as an alternative therapeutic modality in this setting. Although clinical data is limited, the initial evidence and the daily clinical practice point towards a synergistic hybrid treatment strategy based on the combination of drug-coated balloons plus drug-eluting stents, reducing the total stent length and maintaining the scaffolding properties of stents where it is mandatory. Additionally, drug-coated balloons allow natural enlargement of the open vessel after percutaneous coronary intervention (PCI), which is a major limitation of stents in chronic total occlusion (CTO).
Leadless pacemaker technology: clinical evidence of new paradigm of pacing
Authors: Bencardino GIanluigi , Scacciavillani Roberto , Narducci Maria Lucia
Published: February 2022

Despite continuous technological developments, transvenous pacemakers (PM) are still associated with significant immediate and long-term complications, mostly lead or pocket-related. Recent technological advances brought to the introduction in clinical practice of leadless PM for selected cohort of patients. These miniaturize devices are implanted through the femoral vein and advanced to the right ventricle, without leaving leads in place. Lack of upper extremity vascular access and/or high infective risk in patients requiring VVI pacing are the most common indications to leadless PM. The recently introduced MICRA AV leadless PM also allows ventricular synchronization through mechanical sensing of atrial contraction waves, thus solving the problem of AV synchronization. This review will discuss and summarize available clinical evidence on leadless PM, their performance compared to transvenous devices, current applications and future perspectives.
The impact of anxiety level on decision to seek medical care of non-COVID cardiac patients during the pandemic outbreak—single-center experience in Israel
Authors: Koren Ofir , Rajab Saleem Abu , Barbour Mohammad , Shachar Moriah , Shahar Amit , Zubidat Khaled , Slim Wasim , Igbariya Daher , Rozner Ehud , Turgeman Yoav , Naami Robert , Patel Vivek , Naami Edmund , Mader Einat
Published: February 2022

Background: Coronavirus disease 2019 (COVID-19) has significantly the delivery of healthcare all around the world. In part, an abnormal and unexplained high non-COVID-related cardiovascular mortality rate was reported during the outbreak. We assess the correlation between anxiety level and decision to seek medical care (DSMC) during the COVID-19 pandemic. Materials and methods: We recruited patients with cardiovascular complaints admitted to the emergency department in a single institute in Israel between February and September 2020. Anxiety level was measured using available questionnaires. DSMC was assessed with a newly designed questionnaire (DM-19). Results: Two-hundreds seventy patients were included in the study. The mean age was 52.6 ± 14.9 (females represent 36.2%). 23.6% of the patients had at least moderate cardiovascular risk. High anxiety levels were (HAL) reported in nearly half of the patients (57.1% and 49.8% for General Anxiety Disorder Assessment [GAD-7] and Beck Anxiety Inventory [BAI], respectively). It was more prevalent in old, married, and unemployed patients (significant p-value for all in both questionnaires). Age was an independent factor (χ2 = 6.33, p < 0.001, odds-ratio: 4.8) and had a positive correlation on anxiety level (r = 0.81, p < 0.001 and r = 0.62, p < 0.001, for GAD-7 and BAI, respectively). The DM-19 revealed a strong and positive correlation of seeking medical care with anxiety level (R2 linear = 0.44, r = 0.70, p < 0.001 and R2 linear = 0.30, r = 0.58, p < 0.001 for GAD-7 and BAI, respectively) and results in deferring medical care for several days than patient with low anxiety level (p = 0.02). Conclusions: We observed an abnormal prevalence of a high level of anxiety among non-COVID patients with cardiovascular complaints, which affected the patient’s likelihood to seek medical care and resulted in an unreasonable postponement of medical treatment. Our results may explain cardiovascular mortality trends during the outbreak and should be considered in health crisis management. Future studies will involve multi-institutional efforts to address reproducibility of our findings across geographic regions in the state of the global impact. Additionally, it is imperative to understand the effects of the coronavirus vaccine on patient consideration to seek medical care.
Preprocedural features of patients under antihypertensive drugs may help identify responders to renal denervation: a hypothesis-generating study
Authors: Lin Shu-I , Huang Chun-Che , Sung Shih-Hsien , Liu Lawrence Yu-Min , Lin Po-Lin , Lan Wei-Ren , Chao Chuan-Lei , Chiou Wei-Ru , Tsai Cheng-Ting , Wu Yih-Jer , Wang Tzung-Dau , Lee Ying-Hsiang
Published: February 2022

Background: Renal denervation (RDN) is effective to lower systolic blood pressure (SBP) in essential hypertension. However, patient selection under medications remains an important unmet clinical need. Methods: This multicenter study aimed at observing whether preprocedural features associated with increased renin-angiotensin-aldosterone activity influence RDN response. This study enrolled the patients who underwent RDN for uncontrolled hypertension. Medical records were reviewd and patients were divided into 2 groups depending by meeting any of the following conditions prior to RDN: (1) >10 mmHg of office SBP reduction after aldosterone inhibition, (2) aldosterone-renin ratio >30 or (3) slow flow on the renal angiogram. RDN responders were defined by a reduction in 24-hour mean ≥6 mmHg or by ≥1 class of antihypertensive drug withdraw. Results: A total of 46 patients were enrolled, of which 27 (59%) were in control group A and 19 (41%) in group B. The baseline age, gender, office and 24-hour SBP (mean 140.0 ± 12.8 mmHg vs. 144.0 ± 16.5 mmHg, p = 0.577) were comparable, while the number of prescribed drug classes was fewer in group A (4.0 ± 1.3 vs. 4.9 ± 0.9, p = 0.014). The proportion patients with prescribed aldosterone antagonist or high aldosterone-renin ratios were higher in group B. At 12 months post RDN, the results were significantly better in group B in terms of mean change in office SBP (12.4 ± 23.5 mmHg vs. 29.9 ± 25.5 mmHg, p = 0.046) and the proportion of RDN responders (51.9% vs. 89.5%, p < 0.001). Conclusion: RDN was more effective in patients with any of 3 clinical indices.
Relevansi Makna Empat Drama Anak-Anak Berbasis Cerita Dongeng Nusantara Bagi Generasi Masa Kini
Authors: Sahid Nur , - Junaedi
Published: February 2022

Penelitian ini bertujuan untuk menggali makna tanda-tanda  yang terdapat dalam empat drama ’’,Asal-usul Gunung Merapi ‘’, ‘’Putri Si Anak Durhaka’’, ‘’Candra Kirana’’,  dan ‘’Malapetaka Sang Raksasa’’. Teori pendekatan yang dipakai untuk menganalisis adalah semiotika versi Ferdinand De Saussure yang dibantu dengan analisis makna tanda dari Rolanf Barthes. Metode yang dipakai dalam penelitian adalah purposive sampling, sedangkan analisis data menggunakan metode semiotika. Hasil penelitian ini menunjukkan bahwa dongeng Nusantara dapat digubah ke dalam genere seni drama, khususnya drama anak-anak. Dengan digubah ke dalam drama akan memiliki peluang audiens yang lebih luas. Keempat dongeng mengandung makna denotatiie dan konotatif. Makna denotative terkait dengan kesrkahan dan egoisme, ketidakadilan, pegergeseran sistem nilai masyarakat, dan kegigihan dalam mengejar cita-cita, kebaikan melawan kejahatan. Makna konotatif terkait relevansinya semua makna  konotatif dengan kondisi sosial historis masyarakat Indonesia sekarang. Makna-makna keempat dongeng cukup relevan untuk pendidikan moral generasi sekrang, sehinga sudah selayaknya diperkenalkan kepada generasi masa kini.
Banjuran, Gamelan Prosesi Zaman Bali Kuna
Authors: Santosa Hendra , Kustiyanti Dyah , Satyani Ida Ayu Wayan Arya
Published: February 2022

Artikel ini sebagian merupakan hasil penelitian yang berjudul “Evolusi Gamelan Bali”, kemudian ditambah dengan ulasan mengenai perubahan yang terjadi setelah masa Gelgel. Artikel ini bertujuan untuk memberikan gambaran tentang bentuk gamelan Banjuran yang tersurat dalam beberapa prasasti Bali Kuna. Ahli karawitan Bali sering menghubungkannya dengan gamelan Balaganjur yang sekarang berkembang di Bali. Untuk penjelasan secara konfrehensif, artikel ini disusun dengan menggunakan metode sejarah mulai dari heuristik, kritik, interpretasi, dan historiografinya disampaikan melalui penyampaian deskriftif analisis secara kritis. Walaupun sebenarnya zaman sejarah di Bali dimulai dari tahun 804 Masehi melalui prasasti Sukawana AI, tetapi hubungan yang erat antara Bali dengan Jawa Tengah pada sekitar abad ke 7 melalui berbagai temuan arkeologi. Hal ini tentunya membuka dugaan bahwa gambaran gamelan Banjuran terukir dalam relief candi Borobudur. Bentuk kendang Bali yang silinder asimetris banyak terukir dalam reliefnya. Selanjutnya, bentuk kendang Bali juga terukir dalam relief candi Tegawangi di Jawa Timur. Untuk memperjelas bentuk gamelan Banjuran ini, diperkuat pula dengan keterangan dan data-data dari kakawin Nagarakretagama. Gamelan Banjuran diduga merupakan cikal bakal dari perkembangan gamelan Balaganjur yang berkembang dewasa ini.
Nilai Estetika Lokal dan Nilai Ekonomi Lokal Dalam Pengelolaan Destinasi Pariwisata di Bali Utara
Authors: Diyah Sri Widari Dewa Ayu , Prasiasa Dewa Putu Oka
Published: February 2022

Penelitian ini bertujuan menemukan nilai estetika lokal dan nilai ekonomi lokal sebagai dampak dari interaksi nilai lokal dan nilai global dalam pengelolaan destinasi pariwisata di Bali Utara.  Adapun metode yang dipergunakan adalah metode tinjauan pustaka berdasarkan analisis deskriptif kualitatif. Temuan dari penelitian ini adalah unsur lokalitas dalam pengelolaan destinasi pariwisata di Bali Utara terbentuk dari perwujudan nilai estetika dan nilai ekonomi lokal yang diyakini sebagai kearifan lokal masyarakat, dan kedua nilai ini bersifat dominan.  Ni1ai-nilai yang dibawa oleh wisatawan dapat berimplikasi positif (tonic) dan negatif (toxic), sekaligus menjadi penggerak perubaan nilai bagi masyarakat lokal. Kontribusi nilai estetika dan nilai ekonomi lokal terhadap nilai-nilai yang dibawa oleh wisatawan belum optimal dalam pengelolaan destinasi pariwisata di Bali Utara.