bluuebunny/crossref_metadata_2025 huggingface dataset:
Validation of Colorectal Cancer Models on Long-term Outcomes from a Randomized Controlled Trial
Authors: DeYoreo Maria , Lansdorp-Vogelaar Iris , Knudsen Amy B. , Kuntz Karen M. , Zauber Ann G. , Rutter Carolyn M.
Published: October 2020

Microsimulation models are often used to predict long-term outcomes and guide policy decisions regarding cancer screening. The United Kingdom Flexible Sigmoidoscopy Screening (UKFSS) Trial examines a one-time intervention of flexible sigmoidoscopy that was implemented before a colorectal cancer (CRC) screening program was established. Long-term study outcomes, now a full 17 y following randomization, have been published. We use the outcomes from this trial to validate 3 microsimulation models for CRC to long-term study outcomes. We find that 2 of 3 models accurately predict the relative effect of screening (the hazard ratios) on CRC-specific incidence 17 y after screening. We find that all 3 models yield predictions of the relative effect of screening on CRC incidence and mortality (i.e., the hazard ratios) that are reasonably close to the UKFSS results. Two of the 3 models accurately predict the relative reduction in CRC incidence 17 y after screening. One model accurately predicted the absolute incidence and mortality rates in the screened group. The models differ in their estimates related to adenoma detection at screening. Although high-quality screening results help to inform models, trials are expensive, last many years, and can be complicated by ethical issues and technological changes across the duration of the trial. Thus, well-calibrated and validated models are necessary to predict outcomes for which data are not available. The results from this validation demonstrate the utility of models in predicting long-term outcomes and in collaborative modeling to account for uncertainty.
A learning-based harmonic mapping: Framework, assessment, and case study of human-to-robot hand pose mapping
Authors: Chong Eunsuk , Zhang Lionel , Santos Veronica J.
Published: October 2020

Harmonic mapping provides a natural way of mapping two manifolds by minimizing distortion induced by the mapping. However, most applications are limited to mapping between 2D and/or 3D spaces owing to the high computational cost. We propose a novel approach, the harmonic autoencoder (HAE), by approximating a harmonic mapping in a data-driven way. The HAE learns a mapping from an input domain to a target domain that minimizes distortion and requires only a small number of input–target reference pairs. The HAE can be applied to high-dimensional applications, such as human-to-robot hand pose mapping. Our method can map from the input to the target domain while minimizing distortion over the input samples, covering the target domain, and satisfying the reference pairs. This is achieved by extending an existing neural network method called the contractive autoencoder. Starting from a contractive autoencoder, the HAE takes into account a distance function between point clouds within the input and target domains, in addition to a penalty for estimation error on reference points. For efficiently selecting a set of input–target reference pairs during the training process, we introduce an adaptive optimization criterion. We demonstrate that pairs selected in this way yield a higher-performance mapping than pairs selected randomly, and the mapping is comparable to that from pairs selected heuristically by the experimenter. Our experimental results with synthetic data and human-to-robot hand pose data demonstrate that our method can learn an effective mapping between the input and target domains.
Gordon Jelf and his Notes on the Work Conducted in the Theban Necropolis, 1909-1910
Authors: Kaczanowicz Marta
Published: October 2020

In August of 1909, Charles Gordon Jelf joined Arthur E. P. Weigall in Thebes to assist him in the preparation of the famous Topographical Catalogue. Jelf kept a notebook in which he recorded details of archaeological work carried out in the course of the 1909–10 season. The notebook, identified as Jelf’s by Donald P. Ryan and Jaromir Malek, and subsequently donated to the Griffith Institute, contains information on unpublished excavations and finds, as well as other details, including the identity of the person responsible for the rediscovery of the famous tombs of Kheruef (TT 192).
Computed Tomography in Acute Severe Central Nervous System Complications in Children Treated for Cancer: Still a Useful Diagnostic Tool in the Emergency Setting
Authors: Ricci Emilia , Toni Francesco , Marra Chiara , Masetti Riccardo , Porelli Sayuri , Balducci Jessica , Pession Andrea , Cordelli Duccio Maria
Published: October 2020

We retrospectively checked patients who underwent chemotherapy and/or hematopoietic stem cell transplantation from 2007 to 2016, in order to evaluate whether early computed tomography is useful in children treated for cancer with acute central nervous system complications. Out of a total sample of 443 patients, 52 children (11.7%) presented these complications. In the end, 31 patients were included, with a total of 33 events of central nervous system complications. The computed tomography was abnormal in 22 events (67%) and diagnostic for a specific complication in 20 events (61%), whereas it directly influenced the treatment in 16 events (48%). Computed tomography should be still considered a relevant diagnostic tool in the management of acute central nervous system complications in the emergency setting.
Me and Others Around: The Roles of Personal and Social Norms in Chinese Adolescent Bystanders’ Responses Toward Cyberbullying
Authors: Dang Jianning , Liu Li
Published: October 2020

Researchers have expanded the aggressor-victim dyad by showing that bystanders play pivotal roles in the process of cyberbullying. Bystanders’ responses entail moral engagement and are guided by personal and social norms. Most research on normative influences on bystanders’ responses to cyberbullying has focused on personal or social norms but has ignored how they jointly affect bystanders’ responses. Inspiring by the modified Theory of Planned Behavior, a cross-sectional study of Chinese high-school students ( N = 333) examined how cyberbullying-related personal and social norms affect adolescent bystanders’ responses to cyberbullying. We collected information on personal norms, social norms, and bystanders’ responses to cyberbullying. Boys reported stronger intentions than girls to reinforce the bully, but intentions to help the victim were equivalent among boys and girls. Regression analysis revealed that pro-cyberbullying personal and social norms combined could negatively predict intentions to help the victim. However, personal and social norms interacted to influence behavioral intentions to reinforce the bully. Specifically, when pro-cyberbullying social norms were at a high level, a higher level of pro-cyberbullying personal norms was correlated with higher intentions to reinforce the bully. Conversely, when pro-cyberbullying social norms were at a low level, the effect of personal norms disappeared. The findings contribute to understanding the process by which adolescents adapt themselves to norms and provide guidance for educational advice on intervening in cyberbullying.
“Verticalised” cases before the European Court of Human Rights unravelled: An analysis of their characteristics and the Court’s approach to them
Authors: Loven Claire
Published: October 2020

Based on Article 34 European Convention on Human Rights, individual applications must be directed against one of the Convention States. Originally ‘horizontal’ cases therefore must be ‘verticalised’ in order to be admissible. This means that a private actor who had first brought a procedure against another private actor before the domestic courts, must complain about State (in)action in his application to the European Court of Human Rights. Recently, some scholars and judges have raised procedural issues that may arise in these cases, but generally, these ‘verticalised’ cases have remained underexplored. To unravel verticalised cases before the ECtHR and to better understand procedural issues that may arise from them, this article provides a deeper understanding of the origins of verticalised cases and the Court’s approach to them. It is explained that verticalised cases before the ECtHR can be very different in nature. These differences are rooted in the different types of horizontal conflicts that may arise on the domestic level, the different relations between private actors they may concern, and the different Convention rights that may be at stake. The wide variety of verticalized cases is also reflected in the Court’s approach to them, as is the second main topic that the present article explores.
Modeling and theoretical study of relief chamfer method for reducing the flow ripple of a spool valves distribution radial piston pump
Authors: Guo Tong , Lin Tianliang , Ren Haoling , Miao Cheng , Zhao Shengdun
Published: October 2020

This paper presents a study of flow ripple reduction method of a spool valves distribution radial piston pump (SVDRPP). Relief chamfers are adopted to prolong and moderate the opening processes of the delivery spool valves, thus to relieve the pressure surges as well as the consequent flow ripples, vibrations and noises. The mathematical model of this method is established and multiple numerical simulations are conducted to analyze the mechanism as well as the effectiveness of this method. According to the simulation results, different relief chamfer angles have varying influences on flow ripple reduction. Remarkable reduction of flow fluctuation from 43.4% to 36% could be achieved, when the relief chamfer angle is set around 30°. Comparisons between the relief chamfer method and the time delay method indicate that the former has better compatibility to the load pressure lower than the rated value; while the latter has better compatibility to the higher load pressure.
Intraoperative Cell Salvage as an Alternative to Allogeneic (Donated) Blood Transfusion: A Prospective Observational Evaluation of the Immune Response Profile
Authors: Roets Michelle , Sturgess David John , Obeysekera Maheshi Prabodani , Tran Thu Vinh , Wyssusek Kerstin Hildegard , Punnasseril Jaisil Eldo Jos , da Silva Diana , van Zundert Andre , Perros Alexis Jacqueline , Tung John Paul , Flower Robert Lewis Powell , Dean Melinda Margaret
Published: October 2020

Allogeneic blood transfusion (ABT) is associated with transfusion-related immune modulation (TRIM) and subsequent poorer patient outcomes including perioperative infection, multiple organ failure, and mortality. The precise mechanism(s) underlying TRIM remain largely unknown. During intraoperative cell salvage (ICS) a patient’s own (autologous) blood is collected, anticoagulated, processed, and reinfused. One impediment to understanding the influence of the immune system on transfusion-related adverse outcomes has been the inability to characterize immune profile changes induced by blood transfusion, including ICS. Dendritic cells and monocytes play a central role in regulation of immune responses, and dysfunction may contribute to adverse outcomes. During a prospective observational study ( n = 19), an in vitro model was used to assess dendritic cell and monocyte immune responses and the overall immune response following ABT or ICS exposure. Exposure to both ABT and ICS suppressed dendritic cell and monocyte function. This suppression was, however, significantly less marked following ICS. ICS presented an improved immune competence. This assessment of immune competence through the study of intracellular cytokine production, co-stimulatory and adhesion molecules expressed on dendritic cells and monocytes, and modulation of the overall leukocyte response may predict a reduction of adverse outcomes ( i.e., infection) following ICS.
Greenwashing Understanding Among Indian Consumers and Its Impact on Their Green Consumption
Authors: Jog Deepti , Singhal Divya
Published: October 2020

The consumer markets for green personal care products have been expanding rapidly in the past decade and so are the greenwashing practices of the companies. More and more companies are engaging in greenwashing, misleading consumers about their environmental performance or the environmental benefits of a product or service. As the discussion around greenwashing practices has grown in the past few years, consumers have become conscious of their choices and have started understanding the greenwashing practices of companies. The purpose of this empirical study is to assess the greenwashing understanding in Indian consumers’ green purchase behaviour and the effects of receptivity to green advertising, environmental consciousness and personal norm, using structural equation modelling. The findings confirm that the level of greenwashing understanding moderates the relationship between receptivity to green advertising and green purchase behaviour. Additionally, the findings provide that income level has a significant impact on environmental consciousness and green purchase behaviour relationship. The study has possible implications for advertisers, government and other agencies.
Growth and Regional Disparities in Odisha: An Analysis in the Post-reform Period
Authors: Sahoo Priyabrata , Senapati Asis Kumar
Published: October 2020

The post-reform period has witnessed high economic growth in the net state domestic product (NSDP) of the state of Odisha. With a higher growth in income in the post-reform period, especially in the tertiary sector, the state witnessed high regional disparities among its districts in terms of per capita income (PCI). The regional disparities can be assessed by looking at the convergence/divergence in the PCI of the 30 districts of Odisha. The state has seen a sigma ( σ) divergence in the income of districts during the post-reform period, which points to an increase in income disparities among the districts. To know the sectoral effects of the income divergence, the PCI growths of the 30 districts, over the period from 1993–1994 to 2011–2012, are regressed with the initial PCI of the three sectors—primary, secondary and tertiary—of the 30 districts. The beta ( β) divergence shows a mixed result. The districts having a low PCI in the primary sector show a convergence, meaning these were growing at a faster rate and converged with the districts having a high PCI in the primary sector. On the other hand, the districts having a low tertiary sector PCI show a divergence, which means these were growing at a slower rate while districts having a high PCI in the tertiary sector were growing at a faster rate, causing a divergence altogether. The secondary sector PCI of the districts shows an insignificant result. Combining the growth in the sectors’ income and the disparities among the districts in terms of sectoral PCI shows that the growth in income, especially the tertiary sector income growth during the post-reform period in Odisha, caused income disparities among the districts.

JEL: O47, N3, P24, P25
Exploring the Link Between the Hazards and Value of Work, and Overcoming Risk for Community-Based Health Interventions for Immigrant Latinx Low-Wage Workers
Authors: Cuervo Isabel , Tsui Emma K. , Islam Nadia S. , Harari Homero , Baron Sherry
Published: October 2020

Few studies integrate work and immigration as intersecting social determinants of health. We synthesize data from 12 focus groups ( N = 97) originating from two separate community-engaged studies that originally centered on exploring barriers to health and hazards of work among immigrant Latinx women and men to explore the role of work in their overall health and well-being. The three major interrelated themes we drew from this research—hazards of work, value of work, and building agency to overcome risk—provide insights that can help to reframe and begin to operationalize how community-based health promotion practice might better incorporate workplace issues for Latinx low-wage workers. The value of work, and its subtheme, pride in performing well specifically, could be engaged by workers to actively change conditions for themselves and others. We discuss findings in light of previous occupational health research and implications for community-based intervention design and practice.
The Impact of Exploitation and Exploration on Export Sales Growth: The Moderating Role of Domestic and International Collaborations
Authors: Sousa Carlos M.P. , Li Rebecca Yu , He Xinming
Published: October 2020

This study examines the short- and long-term implications of the impact of exploitation and exploration on export sales growth. It also explores the moderating role of external collaborations by differentiating between domestic collaborations and international collaborations. The authors tested their conceptual model with data from the U.K. Community Innovation Survey (2010–2016). Using different time lags for exploitation and exploration, the findings indicate that the impact varies over time. Specifically, they reveal that the effect of exploitation is negative in the long term but positive in the short term, while exploration has no significant effect in the short term but a positive influence on export sales growth in the long term. Similarly, the moderating effect of domestic and international collaborations has been found to vary over time. The authors conclude with a discussion of the theoretical and practical implications.
Leveraging Interfirm Relationships in China: Western Relational Governance or Guanxi? Domestic Versus Foreign Firms
Authors: Chu Zhaofang , Lai Fujun , Wang Linlin
Published: October 2020

With the growing importance of strategic alliances and supply chains as competitive units, academics and practitioners are interested in understanding the techniques used by firms to leverage interfirm relationships to gain a competitive advantage. Studies conducted in the Western context underline the role of relational governance (i.e., the modern Western way), whereas works in the Chinese context highlight the importance of guanxi (i.e., the traditional Chinese way). Today’s Chinese economy operates as a hybrid of the Western modern business model and traditional Chinese patterns with the coexistence of Western relational governance and guanxi. Therefore, this study addresses two issues: (1) whether these two types of governance interact as substitutes or complements in leveraging interfirm relationships and (2) whether and how foreign firms differ from their Chinese domestic counterparts in the use of these two types of governance to improve performance. Drawing on data collected from 132 third-party logistics providers in China, this study shows that Western relational governance and guanxi function as substitutes in improving performance. Moreover, while guanxi contributes to performance in a similar manner in Chinese domestic firms and foreign firms, Western relational governance is more effective for foreign firms than for Chinese domestic firms. Furthermore, the joint role (i.e., interaction effect) of Western relational governance and guanxi in improving performance also differs: these two forms of governance function as substitutes in foreign firms, whereas they have no significant interaction in Chinese domestic firms.
The Intersection of Regional Anesthesia and Cancer Progression: A Theoretical Framework
Authors: Muncey Aaron R. , Patel Sephalie Y. , Whelan Christopher J. , Ackerman Robert S. , Gatenby Robert A.
Published: October 2020

The surgical stress and inflammatory response and volatile anesthetic agents have been shown to promote tumor metastasis in animal and in-vitro studies. Regional neuraxial anesthesia protects against these effects by decreasing the surgical stress and inflammatory response and associated changes in immune function in animals. However, evidence of a similar effect in humans remains equivocal due to the high variability and retrospective nature of clinical studies and difficulty in directly comparing regional versus general anesthesia in humans. We propose a theoretical framework to address the question of regional anesthesia as protective against metastasis.

This theoretical construct views the immune system, circulating tumor cells, micrometastases, and inflammatory mediators as distinct populations in a highly connected system. In ecological theory, highly connected populations demonstrate more resilience to local perturbations but are prone to system-wide shifts compared with their poorly connected counterparts. Neuraxial anesthesia transforms the otherwise system-wide perturbations of the surgical stress and inflammatory response and volatile anesthesia into a comparatively local perturbation to which the system is more resilient. We propose this framework for experimental and mathematical models to help determine the impact of anesthetic choice on recurrence and metastasis and create therapeutic strategies to improve cancer outcomes after surgery.
Chemoimmunotherapy for the salvage treatment of Ewing sarcoma: A case report
Authors: Guven Deniz Can , Kilickap Saadettin , Yildirim Hasan Cagri , Ceylan Furkan , Bas Onur , Dizdar Omer
Published: October 2020

Introduction

Although, immune check-point inhibitors changed the course of many cancers, the outcomes in sarcomas were rather disappointing with less than 10% response rates. Ewing sarcoma is a poorly differentiated and aggressive tumor mostly seen in the children and adolescents. It’s a distinct type of sarcoma with prominent chemosensitivity in the early stages. However, the relapsing disease has a poor prognosis with limited treatment options.

Case report

Herein, we represent a case of relapsed Ewing sarcoma treated with multiple lines of chemotherapy. Management & outcome: The patient had a very good response to salvage treatment with a combination of paclitaxel and nivolumab which lasted for twelve months after the cessation of treatment.

Discussion

We think that chemotherapy plus immunotherapy can be an option for Ewing sarcoma patients treated with multiple lines of chemotherapy.
Home Visiting Effects on Breastfeeding and Bedsharing in a Low-Income Sample
Authors: Mersky Joshua P. , Janczewski Colleen E. , Plummer Lee ChienTi , Gilbert Ross M. , McAtee Cali , Yasin Tajammal
Published: October 2020

Background

Research suggests that home visiting interventions can promote breastfeeding initiation, though their effects on breastfeeding continuation are unclear. No known studies have assessed the impact of home visiting on bedsharing.

Aims

To test the effects of home visiting on breastfeeding and bedsharing in a low-income, urban sample in the United States.

Methods

During a field trial conducted in Milwaukee, Wisconsin, from April 2014 to March 2017, referrals to a public health department were randomized to a Healthy Families America (HFA) program or a prenatal care and coordination (PNCC) program. Of the 204 women who accepted services, 139 consented to the study and were allocated to the two treatment groups, which were compared with each other and a third quasi-experimental group of 100 women who did not accept services. Data were collected at four time points up to 12 months postpartum.

Results

Breastfeeding initiation was higher among 72 HFA participants (88.4%; odds ratio [OR] = 2.7) and 67 PNCC participants (88.5%; OR = 2.2) than 100 comparison participants (76.5%). Similar results emerged for breastfeeding duration, though group differences were not statistically significant. Unexpectedly, bedsharing prevalence was higher among HFA participants (56.5%) than PNCC participants (31.1%; OR = 2.9) and comparison group participants (38.8%; OR = 2.0).

Discussion

Home visiting was linked to increased breastfeeding, while effects on bedsharing varied by program. Progress toward precision home visiting will be advanced by identifying program components that promote breastfeeding and safe sleep.

Conclusion

Further research is needed to examine whether home visiting reduces disparities in breastfeeding and safe sleep practices.
Do State Earned Income Tax Credits Increase Participation in the Federal EITC?
Authors: Neumark David , Williams Katherine E.
Published: October 2020

In recent years, many states and some local governments implemented or expanded their own supplemental earned income tax credits (EITCs). The expansion of state EITCs may have stemmed in large part from wanting to provide a more generous program than the federal program because state EITCs increase transfer payments to low-income recipients who qualify. However, state and local governments can also benefit from maximizing participation of their constituents in the federal EITC, and there are several reasons why state or local EITCs could increase participation in the federal EITC program. We find some evidence suggesting that state EITCs may increase federal EITC program participation among low-skilled single filers with children.
The Impact of Video Gaming Terminals on Casinos and State and Local Tax Revenue
Authors: Phipps Erin Hazel , Nichols Mark W. , Guerrero Federico
Published: October 2020

In 2012, Illinois passed legislation allowing video gaming terminals (VGTs) outside of casinos. This legislation was passed to increase tax revenues from gambling in a market that had seen decreases in revenues and admissions over the past 8 years. VGTs may substitute for casino gambling and have a negative impact on casino and tax revenue. Using ordinary least squares and vector autoregressive models, we find that casino slot revenues decrease by about 0.05 percent for each 1 percent increase in VGT revenues. Admissions decrease by about eleven people per VGT. A Granger causality test suggests causation is running from VGTs to admissions. Thus, there is substitution between VGTs and casino gambling but not so large as to reduce tax revenue. Overall tax revenue from gambling, both casino and VGT, has increased for Illinois. However, local communities where casinos are located have experienced declines in casino tax revenue that have exceeded the gains from VGT revenue.
Metastatic feline mammary cancer: prognostic factors, outcome and comparison of different treatment modalities – a retrospective multicentre study
Authors: Petrucci Gonçalo , Henriques Joaquim , Gregório Hugo , Vicente Gonçalo , Prada Justina , Pires Isabel , Lobo Luís , Medeiros Rui , Queiroga Felisbina
Published: October 2020

Objectives

Although feline mammary carcinomas (FMCs) are highly metastatic, the literature and treatment options pertaining to advanced tumours are scarce. This study aimed to investigate the clinical outcome of metastatic FMC with or without adjuvant treatment.

Methods

The medical records of 73 cats with metastatic FMC (stage IV) were reviewed and included in this study. Metastatic disease was detected by distinct imaging techniques (radiography, ultrasound and CT) and confirmed by cytology and/or histopathology. Cats with adjuvant chemotherapy treatment (n = 34) were divided into three groups: group 1 (n = 9) cats receiving maximum tolerated dose chemotherapy; group 2 (n = 15) cats receiving metronomic chemotherapy; and group 3 (n = 10) cats treated with toceranib phosphate. The study endpoints were time to progression (TTP) and tumour-specific survival (TSS). Treatment-related toxicity was evaluated according to the Veterinary Co-operative Oncology Group’s Common Terminology Criteria for Adverse Events version 1.1 (VCOG-CTCAE).

Results

Overall mean TTP and TSS were 23 and 44 days, respectively. Cats with clinical signs at the time of diagnosis had a lower TSS (14 days) than asymptomatic cats (128 days; P <0.001). Cats with pleural effusion had a lower TSS (16 days) than cats without ( P <0.001). Median TSS was 58, 75 and 63 days in groups 1, 2 and 3, respectively ( P = 0.197). Toxicity was observed in 66.7%, 20% and 30% of cats in groups 1, 2 and 3, respectively.

Conclusions and relevance

To the best of our knowledge, this study includes the highest number of patients with metastatic FMC assessed. Despite the overall poor prognosis, some cats survived >6 months, indicating that adjuvant treatment may be an option to consider in metastatic disease. More studies are warranted for better understanding and management of stage IV patients.
Outcomes of sutureless and sutured scleral fixated intraocular lens in paediatric population
Authors: Sindal Manavi D , Arthi M
Published: October 2020

Purpose:

To analyse the outcomes of sutureless and sutured scleral fixated intraocular lenses (SFIOL) in paediatric population.

Setting:

Vitreoretina department of a tertiary eye care institute in Southern India

Design:

Retrospective case series

Methods:

Data were collected from January 2010 to December 2018 for children less than 18 years of age, based on the following parameters: demographics, pre-operative characteristics, duration between aphakia and surgery, previous amblyopia treatment, the uncorrected (UCVA) and the best corrected visual acuity (BCVA) at baseline and, 1,6 and 12 months or final visit. Early and late post-operative complications along with details of any resurgery was recorded.

Results:

The study included 45 eyes of 43 patients. The mean age when children became aphakic was 8.8±3.6 years and the mean age at SFIOL implantation 10.1 ± 3.9 years. Sutureless SFIOL was performed for 36 (80%) eyes. The improvement in UCVA was statistically significant at 1-month follow up. Transient hypotony (n = 3), vitreous hemorrhage ( n = 7) and raised IOP ( n = 4) were the most observed early post-operative complications, while haptic exposure or disinsertion ( n = 4, 9%) was a delayed postoperative complication. The mean spherical equivalent at the last follow up was 1.96 ± 0.83D and mean postoperative cylinder 2.32 ± 1.3D. The children were followed up for a mean duration of 20 ± 21.7 months. History of previous vitrectomy was found to be associated with two line reduction in UCVA (95% CI = 0.03–0.5 logMAR, p = 0.008).

Conclusion:

SFIOLs- sutured and sutureless; both were suitable for the rehabilitation of paediatric aphakia. Sutureless scleral fixation is a safe alternative for children but prospective studies with longer follow-up are needed.
Biobanking for Cancer Biomarker Research: Issues and Solutions
Authors: Matzke Lise A , Watson Peter H
Published: October 2020

Biomarkers are critical tools that underpin precision medicine. However there has been slow progress and frequent failure of biomarker development. The root causes are multifactorial. Here, we focus on the need for fast, efficient, and reliable access to quality biospecimens as a critical area that impacts biomarker development. We discuss the past history of biobanking and the evolution of biobanking processes relevant to the specific area of cancer biomarker development as an example, and describe some solutions that can improve this area, thus potentially accelerating biomarker research.
Crisis and extended realities: remote presence in the time of COVID-19
Authors: Matthews Benjamin , See Zi Siang , Day Jamin
Published: October 2020

The transformative influence of the COVID-19 pandemic on remote forms of communication has been a frequent theme in popular discourse during 2020, but any lingering transformation of what we do at a distance will rely on convincing and accessible forms of remote presence and interaction. Embodied communication is difficult to simulate, and this discussion examines current and emerging extended reality (XR)–based communication tools in a range of contexts to discover what role they may play in a future where crises of mobility are likely to grow more frequent and protracted. We define XR and its current uses, then examine key terms used to conceptualise it such as ‘presence’ and ‘social presence’, before highlighting social challenges of remote presence and ethical considerations that accompany its use, particularly how the technology might (or fail to) address important social problems, support education and have relevance to the future of work.
Developmental sequences for observing and assessing forceful kicking
Authors: Sacko Ryan S. , Utesch Till , Cordovil Rita , De Meester An , Ferkel Rick , True Larissa , Gao Zan , Goodway Jacqueline , Bott Tim S. , Stodden David F.
Published: October 2020

While football/soccer is the most influential sport in the world, it is surprising that developmental sequences of forceful kicking have not been adequately described and validated in the literature. The purpose of this study was to explore potential developmental sequences for forceful kicking using a prelongitudinal screening method. Data were derived from videotapes of 255 children (girls n = 138, boys: n = 117), ages 4–11 years. Seven potential component sequences in their respective developmental order were initially proposed based on biomechanical and motor developmental principles. Each participant was digitally videoed performing five kicks with maximal effort. Trained research staff coded the initial seven components for each kick and the mode of each participant’s five kicks was used for data analysis. Component level probability curves for each component sequence across age were evaluated using the threshold based generalized partial credit model (Muraki, 1992) within the item response theory framework. As developmental theory would indicate, component levels generally increased with age for most components. Six component ordinal sequence progressions met model requirements (Rel = 0.88, item fit; p > 0.05). Ordinal levels for two components ( Knee action and Follow-through) were altered based on initial empirical model structure fit and the Ball contact component was removed based on a lack of model fit. This study provides sufficient cross-sectional evidence for six component developmental sequences that adequately describe the development of kicking using cross-sectional data. Longitudinal data are required to provide further developmental validation for these sequences.
Telerobotic ultrasound to provide obstetrical ultrasound services remotely during the COVID-19 pandemic
Authors: Adams Scott J , Burbridge Brent , Chatterson Leslie , McKinney Veronica , Babyn Paul , Mendez Ivar
Published: October 2020

Introduction

Obstetrical ultrasound imaging is critical in identifying at-risk pregnancies and informing clinical management. The coronavirus disease 2019 (COVID-19) pandemic has exacerbated challenges in accessing obstetrical ultrasound for patients in underserved rural and remote communities where this service is not available. This prospective descriptive study describes our experience of providing obstetrical ultrasound services remotely using a telerobotic ultrasound system in a northern Canadian community isolated due to a COVID-19 outbreak.

Methods

A telerobotic ultrasound system was used to perform obstetrical ultrasound exams remotely in La Loche, Canada, a remote community without regular access to obstetrical ultrasound. Using a telerobotic ultrasound system, a sonographer 605 km away remotely controlled an ultrasound probe and ultrasound settings. Twenty-one exams were performed in a five-week period during a COVID-19 outbreak in the community, including limited first-, second- and third-trimester exams ( n = 11) and complete second-trimester exams ( n = 10). Participants were invited to complete a survey at the end of the telerobotic ultrasound exam describing their experiences with telerobotic ultrasound. Radiologists subsequently interpreted all exams and determined the adequacy of the images for diagnosis.

Results

Of 11 limited obstetrical exams, radiologists indicated images were adequate in nine (81%) cases, adequate with some reservations in one (9%) case and inadequate in one (9%) case. Of 10 second-trimester complete obstetrical exams, radiologists indicated images were adequate in two (20%) cases, adequate with some reservations in three (30%) cases and inadequate in five (50%) cases. Second-trimester complete obstetrical exams were limited due to a combination of body habitus, foetal lie and telerobotic technology.

Discussion

A telerobotic ultrasound system may be used to answer focused clinical questions such as foetal viability, dating and foetal presentation in a timely manner while minimising patient travel to larger centres and potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), during the COVID-19 pandemic.
Financial Inclusion in India: Does Distance Matter?
Authors: Ghosh Saibal
Published: October 2020

Employing a novel district-level survey data for India, the study investigates the impact of distance on financial inclusion. Using advanced econometric techniques, the findings indicate that distance primarily dampens the use of bank accounts as compared with access. These results are robust irrespective of whether distance is measured in terms of the time taken to reach the banking infrastructure or physical distance. These results are robust to a wide battery of robustness checks. The analysis suggests the need for policy strategies that can address the tyranny of distance towards achieving the financial inclusion goal.
Policy translation in global health governance: Localising harm reduction in Tajikistan
Authors: Kluczewska Karolina , Korneev Oleg
Published: October 2020

This article analyses how global governance frameworks and knowledge claims are translated to fit local contexts. It specifically looks at harm reduction initiatives targeting injection drug users utilising the case of Tajikistan. In the 1990s, this post–Soviet Central Asian country became exposed to an inflow of cheap and easily available heroin from Afghanistan. While Tajikistan mainly became a transit country, some parts of the local population also became addicted. To tackle the negative consequences of heroin addiction, starting from the 1990s international donors proposed the country adopt a range of harm reduction measures, including providing access to opioid substitution therapy and establishing drop-in centres where single-use needles and syringes would be distributed. This article discusses how donor-promoted harm reduction initiatives were localised in Tajikistan, why and with what outcomes. It argues that instead of a full acceptance or rejection of knowledge promoted by international actors, a complex translation process can be observed on the ground. International norms are thus localised by taking into account societal attitudes towards injection drug users, the changing nature of legitimate expertise, evolving national legislation and everyday practices, against the background of other conflicting global governance regimes and local geopolitical priorities.
Anti-inflammatory and atheroprotective properties of glucagon
Authors: Osaka Naoya , Kushima Hideki , Mori Yusaku , Saito Tomomi , Hiromura Munenori , Terasaki Michishige , Yashima Hironori , Ohara Makoto , Fukui Tomoyasu , Matsui Takanori , Hirano Tsutomu , Yamagishi Sho-ichi
Published: October 2020

Although glucagon has been shown to exert pleiotropic actions in various types of cells and organs through the interaction with its receptor, its pathophysiological role in atherosclerotic cardiovascular disease remains unclear. Here, we examined whether and how glucagon could attenuate the progression of atherosclerotic plaques in apolipoprotein E-deficient mice (ApoE−/−), an animal model of atherosclerosis. Glucagon (138 or 413 nmol/kg/day) or vehicle was infused to mice at 16 weeks of age. After 4-week treatment, vascular samples were collected for histological and RT-PCR analyses. Human monocytic THP-1 cells were pre-incubated with or without a glucagon receptor antagonist L-168049, and then treated with or without glucagon for 7 h. Gene and protein expressions were determined by RT-PCR and western blot analyses, respectively. High-dose glucagon infusion significantly decreased aortic plaque area and volume in ApoE−/− mice, both of which were inversely correlated with plasma glucagon levels. Glucagon infusion also reduced the ratio of pro-inflammatory interleukin-1β to anti-inflammatory interleukin-10 gene expression in aortae. Glucagon receptor was expressed in THP-1 cells, and 1 nM glucagon decreased the ratio of interleukin-1β to interleukin-10 gene expression, which was significantly prevented by L-168049. Our present findings suggest that glucagon could exert atheroprotection partly via its anti-inflammatory property.
Lessons Learned From Recruiting Latino Fathers in Child Health Research
Authors: Lindsay Ana Cristina , Valdez Madelyne J. , Pineda Joanna A. , Muñoz Mario A.
Published: October 2020

Latinos are the largest minority population group in the United States, and Latino children currently account for one fourth of U.S. children under age 18. Family is a core value in the Latino culture, and fathers play a central role within the family, including making decisions that influence their children’s health. Nonetheless, Latino fathers are often underrepresented in child health research. This study was designed to describe effective strategies to recruit Latino fathers into five child health research studies. Using a data recruitment log, we collected quantitative and qualitative data on recruitment strategies used to reach and enroll Latino fathers into five child health research studies from 2016 to 2020. Methods classified as direct recruitment strategies involved interaction between potential participants with research staff, whereas indirect methods involved no interaction with research staff and potential participants. In total 113 Latino fathers, majority low-income, immigrant, participated in the studies. Direct recruitment methods in combination with snowball sampling were the most successful strategies for recruiting Latino fathers, contributing to approximately 96% ( n = 107) of the total participants. Indirect methods were much less effective, with social media contributing to only 3.6% ( n = 4) of total participants. Not a single participant was recruited through printed materials (e.g., flyers posted or distributed). Furthermore, qualitative findings revealed the importance of culturally and linguistically relevant approaches in efforts to recruit and enroll Latino fathers. Future research should consider directly asking Latino fathers’ preferences for recruitment and participation in child health research.
Performance of Automated Dissection on Formalin-Fixed Paraffin-Embedded Tissue Sections for the 21-Gene Recurrence Score Assay
Authors: Qi Peng , Bai Qian-ming , Yao Qian-lan , Yang Wen-tao , Zhou Xiao-yan
Published: October 2020

This study aimed to compare the performance of MilliSect dissection and manual dissection. Twenty-five formalin-fixed paraffin-embedded (FFPE) breast cancer tissue blocks were selected for comparison. Specific areas of interest (AOIs) in invasive carcinoma on tissue sections were transferred to dissection slides by manual macrodissection or the MilliSect instrument. The comparison criteria were 1) the time required for dissection; 2) RNA concentration and purity; 3) RNA quantity of 5 housekeeping genes (by RT-qPCR); and 4) ER, PR, HER2, Ki-67 and recurrence score (RS) values (by the 21-gene assay). Then, tumor-adjacent tissues, including fibrocollagenous and epithelial tissues, from the same selected tissue blocks of 8 of 25 patients were scraped using the mesodissection method, and their RS values were assessed to evaluate the influence of tumor-adjacent tissues on the target AOIs. Ultimately, 4 AOIs of invasive ductal carcinoma (IDC) from 1 tissue block of another 4 patients with lymph node (LN) metastases each, LN tissue and a mixture of IDC and LN tissue from the other tissue block of the same 4 patients were mesodissected to evaluate the influence of infiltrating lymphocyte levels on the RS values of AOIs. In our experience, the MilliSect instrument, which provides process management documentation, required more time than manual macrodissection (on average, approximately 9.1 min per sample versus 5.8 min per sample, respectively). The RNA yield and quality of the dissected tissues were comparable for the 2 methods. However, the tumor-adjacent tissues of the AOIs may influence the RS to some extent. Tumor-infiltrating lymphocytes (TILs) can dramatically increase RSs, far exceeding the influence of tumor-adjacent fibrocollagenous and epithelial tissues. In conclusion, MilliSect mesodissection is comparable to manual dissection. This mesodissection tool may facilitate AOI alignment and the dissection process for the 21-gene RS assay. Samples whose adjacent tissues are intermixed with TILs warrant special attention.
Upregulation of miR-124-3p by Liver X Receptor Inhibits the Growth of Hepatocellular Carcinoma Cells Via Suppressing Cyclin D1 and CDK6
Authors: Zhong Dan , Lyu Xilin , Fu Xiaohong , Xie Peng , Liu Menggang , He Fengtian , Huang Gang
Published: October 2020

MiR-124-3p has been identified as a novel tumor suppressor and a potential therapeutic target in hepatocellular carcinoma (HCC) through regulating its target genes. However, the upstream regulatory mechanisms of mir-124-3p in HCC has not been fully understood. The transcription factor liver X receptor (LXR) plays a critical role in suppressing the proliferation of HCC cells, but it is unclear whether LXR is involved in the regulation of mir-124-3p. In the present study, we demonstrated that the expression of mir-124-3p was positively correlated with that of LXR in HCC, and the cell growth of HCC was significantly inhibited by LXR agonists. Moreover, activation of LXR with the agonists up-regulated the expression of mir-124-3p, and in turn down-regulated cyclin D1 and cyclin-dependent kinase 6 (CDK6) expression, which are the target genes of mir-124-3p. Mechanistically, miR-124-3p mediates LXR induced inhibition of HCC cell growth and down-regulation of cyclin D1 and CDK6 expression. In vivo experiments also confirmed that LXR induced miR-124-3p expression inhibited the growth of HCC xenograft tumors, as well as cyclin D1 and CDK6 expression. Our findings revealed that miR-124-3p is a novel target gene of LXR, and regulation of the miR-124-3p-cyclin D1/CDK6 pathway by LXR plays a crucial role in the proliferation of HCC cells. LXR-miR-124-3p-cyclin D1/CDK6 pathway may be a novel potential therapeutic target for HCC treatment.
A New Method Involving Percutaneous Application in the Treatment of Deep Venous Insufficiency: An Experimental Study With Internal Compression Therapy in a Porcine Model
Authors: Yasim Alptekin , Eroglu Erdinc , Kocarslan Sezen , Yoldas Atila , Acipayam Mehmet , Kocarslan Aydemir , Daglioglu Kenan
Published: October 2020

Introduction:

To study the efficiency of internal compression therapy (ICT), a new and promising method of treatment for deep venous insufficiency, how that efficiency is achieved, and its potential side-effects, in a porcine model.

Material and Methods:

The femoral vein diameters of 4 pigs were first measured. ICT was then applied such as to reduce the diameter of these veins by 50%. The femoral vein diameters of 2 pigs were re-measured after 1 month. The femoral vein and its surrounding tissue were excised for immunohistopathological and genetic examination. The same procedures were applied to the remaining 2 pigs 3 months subsequently. Collagen I and IV immunohistochemical staining and Masson’s trichrome and Alcian blue histochemical staining were applied during immunohistopathological examination. Collagen I, III, and IV and connective tissue growth factor (CTGF) mRNA expressions were examined for genetic examination.

Results:

The femoral vein diameters decreased by approximately 50% after ICT application. This decrease persisted after the first and third months. Histopathological examination revealed loose connective tissue around the venous tissue after the operation, particularly in the third month, together with perivascular fibrosis and increased collagen in connective tissue. No difference was observed between regions with and without ICT application in terms of mucinous degeneration, an indicator of tissue injury, during Alcian blue staining. Genetic examination revealed an increase in collagen I and IV and CTGF mRNA expression in perivascular tissue resulting from ICT application.

Conclusion:

ICT is effective both in terms of creating a durable tissue around the vein and of increasing collagen tissue and stimulating fibrosis, and has no deleterious side-effects on tissue.