bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Isolation of Phenol- and Thiol-Derived Epicatechin Adducts Prepared from Avocado Peel Procyanidins Using Centrifugal Partition Chromatography and the Evaluation of Their Antimicrobial and Antioxidant Activity
Authors: Berrios-Henríquez Barbara , Venegas-Toloza Matías , Reyes-Fuentes María , Zúñiga-Arbalti Felipe , Bustamante Luis , García-Cancino Apolinaria , Alarcón-Enos Julio , Pastene-Navarrete Edgar
Published: June 2024

Polyphenols from agro-food waste represent a valuable source of bioactive molecules that can be recovered to be used for their functional properties. Another option is to use them as starting material to generate molecules with new and better properties through semi-synthesis. A proanthocyanidin-rich (PACs) extract from avocado peels was used to prepare several semi-synthetic derivatives of epicatechin by acid cleavage in the presence of phenol and thiol nucleophiles. The adducts formed by this reaction were successfully purified using one-step centrifugal partition chromatography (CPC) and identified by chromatographic and spectroscopic methods. The nine derivatives showed a concentration-dependent free radical scavenging activity in the DPPH assay. All compounds were also tested against a panel of pathogenic bacterial strains formed by Listeria monocytogenes (ATCC 7644 and 19115), Staphylococcus aureus (ATCC 9144), Escherichia coli (ATCC 11775 and 25922), and Salmonella enterica (ATCC 13076). In addition, adducts were tested against two no-pathogenic strains, Limosilactobacillus fermentum UCO-979C and Lacticaseibacillus rhamnosus UCO-25A. Overall, thiol-derived adducts displayed antimicrobial properties and, in some specific cases, inhibited biofilm formation, particularly in Listeria monocytogenes (ATCC 7644). Interestingly, phenolic adducts were inactive against all the strains and could not inhibit its biofilm formation. Moreover, depending on the structure, in specific cases, biofilm formation was strongly promoted. These findings contribute to demonstrating that CPC is a powerful tool to isolate new semi-synthetic molecules using avocado peels as starting material for PACc extraction. These compounds represent new lead molecules with antioxidant and antimicrobial activity.
Antioxidant Properties of Platycladus orientalis Flavonoids for Treating UV-Induced Damage in Androgenetic Alopecia Hair
Authors: Xu Chuntao , Dai Jiawei , Du Weian , Ji Hongbing
Published: June 2024

Background: Androgenetic alopecia (AGA) causes thinning hair, but poor hair quality in balding areas and damage from UV radiation have been overlooked. Plant extracts like Platycladus orientalis flavonoids (POFs) may improve hair quality in AGA. This study examines POFs’ effectiveness in treating AGA-affected hair and repairing UV-induced damage. Methods: Hair samples were analyzed using scanning electron microscopy (SEM) to examine surface characteristics, electron paramagnetic resonance (EPR) spectroscopy to measure free radicals in the hair, and spectrophotometry to assess changes in hair properties. Results: POFs effectively removed hydroxyl radicals from keratinocytes and had antioxidant properties. They also reduced UV-induced damage to AGA hair by mitigating the production of melanin free radicals. Following POF treatment, the reduction in peroxidized lipid loss in AGA hair was notable at 59.72%, thereby effectively delaying the progression of hair color change. Moreover, protein loss decreased by 191.1 μ/g and tryptophan loss by 15.03%, ultimately enhancing hair’s tensile strength. Conclusion: compared to healthy hair, hair damaged by AGA shows more pronounced signs of damage when exposed to UV radiation. POFs help protect balding hair by reducing oxidative damage and slowing down melanin degradation.
The Whole-Genome Sequencing and Probiotic Profiling of Lactobacillus reuteri Strain TPC32 Isolated from Tibetan Pig
Authors: Kong Qinghui , Shang Zhenda , Nawaz Shah , Liu Suozhu , Li Jiakui
Published: June 2024

Gut microbiota are the microbial organisms that play a pivotal role in intestinal health and during disease conditions. Keeping in view the characteristic functions of gut microbiota, in this study, Lactobacillus reuteri TPC32 (L. reuteri TPC32) was isolated and identified, and its whole genome was analyzed by the Illumina MiSeq sequencing platform. The results revealed that L. reuteri TPC32 had high resistance against acid and bile salts with fine in vitro antibacterial ability. Accordingly, a genome sequence of L. reuteri TPC32 has a total length of 2,214,495 base pairs with a guanine–cytosine content of 38.81%. Based on metabolic annotation, out of 2,212 protein-encoding genes, 118 and 101 were annotated to carbohydrate metabolism and metabolism of cofactors and vitamins, respectively. Similarly, drug-resistance and virulence genes were annotated using the comprehensive antibiotic research database (CARD) and the virulence factor database (VFDB), in which vatE and tetW drug-resistance genes were annotated in L. reuteri TPC32, while virulence genes are not annotated. The early prevention of L. reuteri TPC32 reduced the Salmonella typhimurium (S. Typhimurium) infection in mice. The results show that L. reuteri TPC32 could improve the serum IgM, decrease the intestinal cytokine secretion to relieve intestinal cytokine storm, reinforce the intestinal biochemical barrier function by elevating the sIgA expression, and strengthen the intestinal physical barrier function. Simultaneously, based on the 16S rRNA analysis, the L. reuteri TPC32 results affect the recovery of intestinal microbiota from disease conditions and promote the multiplication of beneficial bacteria. These results provide new insights into the biological functions and therapeutic potential of L. reuteri TPC32 for treating intestinal inflammation.
Joint B Vitamin Intake and Type 2 Diabetes Risk: The Mediating Role of Inflammation in a Prospective Shanghai Cohort
Authors: Zhu Yang , Ying Tao , Xu Mingjing , Chen Qing , Wu Min , Liu Yuwei , He Gengsheng
Published: June 2024

Background and Aims: Type 2 diabetes (T2D) is a global and complex public health challenge, and dietary management is acknowledged as critical in its prevention. Recent studies have highlighted the involvement of micronutrients in T2D pathophysiology; our study aims to assess the association between B vitamin intake and T2D risks and the mediating role of inflammation. Methods: In a prospective cohort design, data on B vitamins intake, including thiamine (B1), riboflavin (B2), niacin (B3), pyridoxine (B6), folate (B9), and cobalamin (B12), was obtained using a validated food frequency questionnaire (FFQ), and blood inflammatory biomarkers were analyzed according to standard protocol in the local hospitals at baseline from 44,960 adults in the Shanghai Suburban Adult Cohort and Biobank (SSACB). Incident T2D cases were identified according to a physician’s diagnosis or medication records from the electronic medical information system. We employed logistic and weighted quantile sum regression models to explore the associations of single and combined levels of B vitamins with T2D and mediation analyses to investigate the effects of inflammation. Results: Negative correlations between B vitamins and T2D were observed in the single-exposure models, except for B3. The analyses of joint exposure (B1, B2, B6, B9, and B12) also showed an inverse association (OR 0.80, 95% CI 0.71 to 0.88), with vitamin B6 accounting for 45.58% of the effects. Further mediation analysis indicated a mediating inflammatory impact, accounting for 6.72% of the relationship. Conclusions: Dietary intake of B vitamins (B1, B2, B6, B9, B12) was associated with a reduced T2D risk partially mediated by inflammation in Shanghai residents.
The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial
Authors: Žmitek Katja , Žmitek Janko , Hristov Hristo , Rogl Butina Mirjam , Keršmanc Petra , Pogačnik Tina
Published: June 2024

Collagen dietary supplements are becoming increasingly popular as a means to reduce signs of skin ageing. The objective of this three-way, randomised, placebo-controlled, double-blind study was to examine and contrast the effects of dietary supplementation with a daily dose of 5 g hydrolysed collagen with 80 mg of vitamin C (CP product) and their combination with 30 mg of hyaluronic acid (CPHA product) over 16 weeks. Validated methods were utilised for the objective evaluation of skin parameters. In total, 87 subjects (women, 40–65 years) completed the entire trial, distributed across the groups as follows: placebo group (n = 29), CPHA group (n = 28), and CP group (n = 30). The results showed beneficial effects of both test products, with notable enhancements in dermis density, skin texture, and a reduction in the severity of wrinkles. In contrast, the administration of either of the products did not yield any significant impacts on skin elasticity or hydration. Observation of the investigated skin parameters did not show superior effects of the addition of hyaluronic acid (HA) to collagen. Therefore, the ability of supplementation with HA to improve the effects on investigated skin parameters beyond the supplementation of collagen alone cannot be confirmed.
The Relationship between Low-Sodium Salt Intake and Both Blood Pressure Level and Hypertension in Chinese Residents
Authors: Wang Cuicui , Lu Zilong , Zhang Jiyu , Chen Xiaorong , Xu Jianwei , Zhang Bingyin , Dong Jing , Ren Jie , Xu Chunxiao , Gao Congcong , Guo Xiaolei , Wu Jing , Ma Jixiang
Published: June 2024

Compared to common salt, low-sodium salt can reduce blood pressure to varying degrees. However, the exact dosage relationship remains unclear. We aimed to investigate the dose–response relationships between low-sodium salt intake and systolic blood pressure (SBP) and diastolic blood pressure (DBP), as well as the risk of hypertension, and to determine the optimal range for low-sodium salt intake. We investigated the basic characteristics and dietary profile of 350 individuals who consumed low-sodium salt. The samples were divided into three groups according to the 33.3rd and 66.6th percentiles of low-sodium salt intake in condiments (Q1: <4.72 g/d, Q2: ≥4.72 g/d, and <6.88 g/d, and Q3: ≥6.88 g/d). The restricted cubic spline results indicated that low-sodium salt intake decreased linearly with SBP and DBP, while low-sodium intake demonstrated a non-linear, L-shaped relationship with the risk of hypertension, with a safe range of 5.81 g to 7.66 g. The multiple linear regression analysis revealed that compared with group Q1, the DBP in group Q2 decreased by 2.843 mmHg (95%CI: −5.552, −0.133), and the SBP in group Q3 decreased by 4.997 mmHg (95%CI: −9.136, −0.858). Exploratory subgroup analyses indicated that low-sodium salt intake had a significant impact on reducing SBP in males, DBP in females, SBP in rural populations, and DBP in urban populations. The intake of low-sodium salt adheres to the principle of moderation, with 5.81–7.66 g potentially serving as a pivotal threshold.
In Vitro/In Vivo Correlation of Two Extended-Release Cilostazol Formulations
Authors: Min Kyoung Ah , Kim Na Young , Jin Min Jeong , Kim Doyeon , Ma Yoonseo , Karna Sandeep , Park Young-Joon
Published: June 2024

This study aims to evaluate and determine the correlation between in vitro release and in vivo pharmacokinetics of two extended-release dosage forms of Cilostazol. In vitro release profiles for two dosage forms, tablet and capsule, were analyzed under physiologically mimicked medium conditions using the paddle and basket USP release apparatus. A single-dose, two-period crossover study design in beagle dogs was applied for the pharmacokinetic study. The fed and fast effects were considered for evaluation. Pseudo gastric release medium transfer setup study from pH 1.2 to pH 6.8 (+0.5% SLS) and pH 1.2 to pH 6.8 (+1.0% SLS) demonstrated that Pletaal® SR 200 mg capsules have higher drug release rates than Cilostan® CR 200 mg tablets. Similarly, in vivo study showed Cilostazol concentration in plasma and AUC was lower under the fast state than the fed state. The ratio of least squared geometric mean values, Cmax, AUC0-t, and AUC0-inf of Cilostazol were 2.53-fold, 2.89-fold, and 2.87-fold higher for Pletaal® SR 200 mg capsules compared with Cilostan® CR 200 mg tablets, respectively. Correlation of in vitro/in vivo data indicated that Pletal® SR 200 mg capsules have better release and pharmacodynamic effect than Cilostan® CR 200 mg tablets.
Approved and Commercialized Antidiabetic Medicines (Excluding Insulin) in Seven European Countries—A Cross-Sectional Comparison
Authors: Atănăsoie Ana-Maria , Ancuceanu Robert Viorel , Krajnović Dušanka , Waszyk-Nowaczyk Magdalena , Skotnicki Marcin , Tondowska Dorota , Petrova Guenka , Niculae Andrei Marian , Tăerel Adriana-Elena
Published: June 2024

Diabetes mellitus is a complex, multifactorial, progressive condition with a variety of approved therapeutic options. The purpose of this study was to offer an overview of the authorized antidiabetic medicines (excluding insulin) compared with marketed products in seven European countries. Data were obtained from primary sources, including the websites of national authorities and directly from specialists in the countries of interest. The range of marketed medicines compared with the authorized group was assessed in terms of active pharmaceutical ingredients (>60% in Bulgaria, France, Serbia), brand names (>70% in Bulgaria, the Czech Republic, Romania, Serbia, Spain), pharmaceutical forms (>60% in all countries), strengths (>60% in Bulgaria, the Czech Republic, Romania, Serbia, Spain), marketing authorization holder (≥50% in all countries) and the status of medicine. Spain was found to have the highest number of products based on most of these attributes. Over 90% of authorized medicines had a pharmacy price in Serbia. Regarding the newer class of GLP-1 receptor agonists, a retail price for all approved substances was available in Bulgaria, Romania, Serbia, and Spain. Only one brand name with one concentration was found available for some agents, being susceptible to drug shortages: glibenclamide (Romania, Serbia, Spain), glipizide (the Czech Republic, Poland, Romania, Spain), glisentide (Spain), acarbose (the Czech Republic), sitagliptin (Bulgaria, Poland), vildagliptin (the Czech Republic, Poland) and saxagliptin (the Czech Republic, France, Romania, Serbia). An overview of the national and international therapeutic options may allow competent authorities and health professionals to take rapid measures in case of supply problems or health crises.
Generating Optical Vortex Array Laser Beams of Superimposing Hermite–Gaussian Beams with a Dual–Phase Modulation Digital Laser System
Authors: Nguyen Thi Ly Ly , Tsai Ko-Fan , Chu Shu-Chun
Published: June 2024

This study presents an efficient and practical intra-cavity approach for selectively generating vortex array laser beams employing a dual-phase modulation digital laser system, which has not yet been completed in single-phase modulation digital laser. The stable optical vortex array laser beams were formed by superimposing cavity Hermite–Gaussian (HG) eigenmodes. In particular, when the selected cavity HG modes shared the same Gouy phase, the resulting optical vortex beam could preserve its light field pattern, thereby maintaining the optical vortex properties in the near and far fields. Numerical results demonstrated that employing dual-phase modulation could establish optimal boundary conditions for the selection of HG modes within the cavity, successfully generating various vortex array laser beams. The experimental validation of the proposed method confirmed the ability to select optical vortex array lasers solely by controlling the loaded phase of the dual-phase modulation digital laser. These results demonstrate the ability of digital lasers to generate and dynamically control optical vortex array lasers.
Crystallization of the β-Form of Polypropylene from the Melt with Reduced Entanglement of Macromolecules
Authors: Krajenta Justyna , Pawlak Andrzej
Published: June 2024

The influence of decreasing the entanglement density of macromolecules on the crystallization of the β-form of polypropylene was investigated. Polypropylene with seven times less entanglement was obtained from a solution in xylene, and its properties were compared with those of fully entangled polypropylene. To obtain a high β-phase content, the polymer was nucleated using calcium pimelate. In non-isothermal crystallization studies, accelerated growth of β-crystals was found, increasing the crystallization temperature. Also, the isothermal crystallization was fastest in the nucleated, partially disentangled polypropylene. Increased growth rate of spherulites and enhanced nucleation activity in the presence of more mobile macromolecules were responsible for the high rate of melt conversion to crystals in the disentangled polypropylene. It was also observed that the equilibrium melting temperature of β-crystals is lower after disentangling macromolecules. Better conditions for crystal building after reduction of entanglements resulted in enhanced crystallization according to regime II.
Novel High-Performance Functionalized and Grafted Bio-Based Chitosan Adsorbents for the Efficient and Selective Removal of Toxic Heavy Metals from Contaminated Water
Authors: Monir Mohammad , Elsayed Rasha E. , Azzam Rasha A. , Madkour Tarek M.
Published: June 2024

Novel functionalized and/or grafted crosslinked chitosan adsorbents were synthesized and used to remove several toxic heavy metal ions such as nickel, lead, chromium, and cadmium ions from contaminated water. The chitosan biopolymer was functionalized by maleic anhydride (CS_MA) acting also as a crosslinking agent. Glutaraldehyde-crosslinked chitosan (CS_GA) grafted with poly(methyl methacrylate) (CS_MMA) was also synthesized. The synthesized adsorbents were characterized using a variety of analytical techniques such as SEM, TGA, and FTIR, which confirmed their chemical structures and morphology. The adsorption capacity of the adsorbents was analyzed under various conditions of contact time, adsorbent dose, initial concertation, temperature, and pH and evaluated against those of pure chitosan (CS) and the crosslinked chitosan(CS_GA). The ultimate removal conditions were 0.5 g/100 mL adsorbent dose, an initial metal ion concentration of 50 ppm, a temperature of 45 °C, and pH 9. CS_MMA had the highest removal percentages for all metal ions, ranging from 92% to 94%. The adsorption was demonstrated to fit a pseudo-first-order model that followed a Langmuir adsorption isotherm. The results highlight the capacity of the synthesized polymers to efficiently remove major toxic contaminants at low cost from contaminated water, present especially in low-income areas, without harming the environment.
A Review of EPDM (Ethylene Propylene Diene Monomer) Rubber-Based Nanocomposites: Properties and Progress
Authors: Costa Naiara Lima , Hiranobe Carlos Toshiyuki , Cardim Henrique Pina , Dognani Guilherme , Sanchez Juan Camilo , Carvalho Jaime Alberto Jaramillo , Torres Giovanni Barrera , Paim Leonardo Lataro , Pinto Leandro Ferreira , Cardim Guilherme Pina , Cabrera Flávio Camargo , dos Santos Renivaldo José , Silva Michael Jones
Published: June 2024

Ethylene propylene diene monomer (EPDM) is a synthetic rubber widely used in industry and commerce due to its high thermal and chemical resistance. Nanotechnology has enabled the incorporation of nanomaterials into polymeric matrixes that maintain their flexibility and conformation, allowing them to achieve properties previously unattainable, such as improved tensile and chemical resistance. In this work, we summarize the influence of different nanostructures on the mechanical, thermal, and electrical properties of EPDM-based materials to keep up with current research and support future research into synthetic rubber nanocomposites.
Reaction–Thin Film Evaporation Coupling Technology for Highly Efficient Synthesis of Higher Alkyl Methacrylate
Authors: Liu Lele , Zhang Yao , Su Shuo , Yu Kun , Nie Fengmin , Li Yong
Published: June 2024

The traditional methacrylic esterification process, which couples reaction–distillation/rectification, suffers from issues such as prolonged reaction time, high risk of self-polymerization, and low utilization rate of methacrylic acid. By optimizing the esterification reaction of methacrylic acid through reaction–thin film evaporation coupling, compared to the reaction–distillation coupling process, the reaction time could be reduced by 37.50%, the reaction temperature could be lowered by over 15 °C, and the yield of etherification of dodecanol could be decreased by 81.25%, which significantly mitigates the risk of self-aggregation and reduces energy consumption. Furthermore, the feasibility of recovery of methacrylic acid from aqueous phase through extraction with higher aliphatic alcohol was verified, the recovery rate of methacrylic acid could reach above 96.95%, and the extracted phase could be directly utilized for preparing raw material for esterification reaction without requiring further separation steps, which effectively enhances the process economy and atomic utilization.
Ibuprofen Formulations: Permeability and Biodegradability Comparison Depending on the Type of Formulation
Authors: Kucharska Edyta , Ok Berin , Nowak Anna , Kucharski Łukasz , Muzykiewicz-Szymańska Anna , Ossowicz-Rupniewska Paula
Published: June 2024

This study assesses ibuprofen’s permeability to different formulations and their biodegradation. Hydrogel, organogel, Eucerin ointment, silicone ointment, and zinc ointment were investigated. The objective was to comprehensively evaluate the therapeutic efficacy and environmental implications of these formulations. Diverse formulations were examined through the utilisation of Franz diffusion chambers to evaluate the in vitro permeability of both ibuprofen and ibuprofenate sodium. Moreover, biodegradation studies of the obtained formulations were carried out with activated sludge. The activity of the inoculum was confirmed by using SDS as a reference compound. The experimental settings used (carbon content and inoculum volume) were selected based on the criteria set by the OECD guidelines. Relevant parameters pertaining to the biodegradation process were estimated, including biodegradation values (%B) at specific time points, half-lives of initial compounds and API-containing formulations, and degradation phases (lag phase I; degradation phase II, and plate phase III). For comparison purposes, biodegradation studies were also carried out for the initial IBU and IBUNa compounds under the same conditions. The environmental implications of these findings underscore the need for a balanced consideration of therapeutic efficacy and environmental sustainability in pharmaceutical formulation design. This study provides valuable insights for pharmaceutical researchers, environmental scientists, and regulatory bodies involved in the development and assessment of drug formulations. The proposed method of removing NSAIDs from aquatic ecosystems is a cheaper alternative to techniques such as reverse osmosis, oxidation, UV degradation, or photolysis, which have not found practical use owing to the generation of toxic sludge or high capital and operating costs.
Numerical Simulation and Experimental Study of Gas–Solid Two-Phase Spraying of Dry Powder Fire-Extinguishing System Based on Fire-Extinguishing Inspection Robot
Authors: Chu Shengli , Chen Tao , Gan Yifan , Liu Yixin , Zheng Wenpei , Tang Yan , Zhou Wendong
Published: June 2024

In order to solve the problem where the traditional intelligent inspection robot only has a single inspection function, we studied the use of a dry powder (including an ultra-fine dry powder) as a fire-extinguishing medium for the first time. In fire-extinguishing robots, the spray pressure is difficult to control, and there are several other issues. For integrated inspection, an intelligent, nitrogen-driven fire-extinguishing robot using a dry powder in a pressure-controlled spray was developed. On this basis, in order to investigate nitrogen-driven dry powder particle spraying as a gas–solid two-phase mechanism, as well as the flow characteristics and the influence of relevant parameters on the spraying effect, a nitrogen-driven dry powder particle spraying system was established as part of a gas–solid two-phase computational fluid dynamics model. The flow field of the spraying system and the particle motion characteristics were analyzed to explore the micro-mechanisms of the influence of different driving pressures, pipe diameters, and nozzle configurations on the spraying of the dry powder. In order to investigate the macroscopic effect of dry powder spraying where the gas–solid two-phase micro-mechanisms could not be revealed, an experimental platform was set up, and the experiments verified the accuracy of the numerical simulation results. We also investigated the dry powder spraying effect under different driving pressures, pipe diameters, nozzle configurations, and loading ratios. Finally, an orthogonal test was designed based on the results of the single-factor experiments to find the best combination of parameters required to achieve the optimal spraying effect. The research results can provide a theoretical and technical reference for the design and development of nitrogen-driven dry powder spraying systems.
Analysis of Fault Influence on Geostress Perturbation Based on Fault Model Test
Authors: Tian Shuang , Qiao Yan , Zhang Yang , Hu Dawei , Zhou Hui , Iqbal Sayed Muhammad
Published: June 2024

The distribution of the geostress field in reservoirs holds significant implications for the precise exploration and efficient development and utilization of oil and gas resources, especially in deep strata regions where faults are prevalent. Geological structural movements in these deep strata regions exacerbate the complexity of geostress field distributions. To elucidate the perturbation of the geostress field in deep reservoirs caused by faults, this study initially conducted a series of physical model tests on single fault dislocation, employing digital image correlation techniques to capture the displacement fields of various types of fault dislocations. Subsequently, a numerical model of the fault interface element was established, and fault element parameters were determined through sensitivity analysis and trial calculation. This study further analyzed the perturbation of the geostress field using this numerical model. Finally, a multi-fault numerical simulation model was constructed to clarify the perturbations in the regional geostress field under the influence of multiple faults. The results indicate that the geostress perturbation range under the action of multiple faults spans from 183.06 to 310.06 m.
A Review of Fracturing and Enhanced Recovery Integration Working Fluids in Tight Reservoirs
Authors: Shang Jianping , Dong Zhengliang , Tan Wenyuan , Zhang Yanjun , Liang Tuo , Xing Liang , Wang Zhaohuan
Published: June 2024

Tight reservoirs, characterized by low porosity, low permeability, and difficulty in fluid flow, rely on horizontal wells and large-scale hydraulic fracturing for development. During fracturing, a significant volume of fracturing fluid is injected into the reservoir at a rate far exceeding its absorption capacity. This not only serves to create fractures but also impacts the recovery efficiency of tight reservoirs. Therefore, achieving the integration of fracturing and enhanced recovery functions within the working fluid (fracturing-enhanced recovery integration) becomes particularly crucial. This study describes the concept and characteristics of fracturing-enhanced recovery integration and analyzes the types and features of working fluids. We also discuss the challenges and prospects faced by these fluids. Working fluids for fracturing-enhanced recovery integration need to consider the synergistic effects of fracturing and recovery; meet the performance requirements during fracturing stages such as fracture creation, proppant suspension, and flowback; and also address the demand for increased recovery. The main mechanisms include (1) enlarging the effective pore radius, (2) super-hydrophobic effects, and (3) anti-swelling properties. Fracturing fluids are pumped into fractures through pipelines, where they undergo complex flow in multi-scale fractures, ultimately seeping through capillary bundles. Flow resistance is influenced by the external environment, and the sources of flow resistance in fractures of different scales vary. Surfactants with polymerization capabilities, biodegradable and environmentally friendly bio-based surfactants, crosslinking agents, and amino acid-based green surfactants with outstanding properties will unleash their application potential, providing crucial support for the effectiveness of fracturing-enhanced recovery integration working fluids. This article provides important references for the green, efficient, and sustainable development of tight oil reservoirs.
“The Gates of Eternal Life”: Metamorphosis and Performativity in Middle to Late Byzantine Sculpted Church Doors (with a Case Study of a Wallachian Wooden Door)
Authors: Negrău Elisabeta
Published: June 2024

In recent years, there has been a growing interest in analyzing the manufacturing techniques of Byzantine church doors in laboratory settings. However, the connection between the iconography and significance of the décor of church doors and their liturgical performativity, as well as their parallels with iconostases in Byzantium, remained a relatively underexplored area of study. This article seeks to delve deeper into these intersections. By focusing on the relationship between the iconography of church doors in Middle to Late Byzantium and their connection to the sacred space and liturgical practices, I aim to shed light on how these artworks played a crucial role in the sacred experience of the Byzantines. This exploration will not highlight only the aesthetic evolution of church door artwork but also emphasize the communal and embodied nature of the religious experience during the Byzantine era. Their intricate designs were not merely decorative elements but served as portals to the divine, enriching the salvation journey of worshippers as they crossed the threshold into the liturgical spaces. By conducting an examination of the development of door iconography and their symbolism throughout the empire’s history, the transformation of narrative depictions from the Middle Byzantine era to the Palaiologan period, culminating in a convergence of symbolic meanings within the sacred space of the church, is delineated. This transformation is further exemplified by a sculpted church door from the Principality of Wallachia. By bridging the gap between art history and religious studies, this article aims to rekindle interest in the profound symbolism and significance of Byzantine church doors and their relation to sacred liturgical space, offering a broader perspective on an important aspect of Byzantine heritage.
Defending the “Backward Civilization”: The Resurrection of a Forgotten 17th Century Text in 20th Century Intellectual Discourse on Islam
Authors: İzgi Mahmut Cihat , Erbay Enes Ensar
Published: June 2024

It is an irony of history that since texts transcend the intentions and purposes of their authors, their meaning and significance are often contested anew as they enter new historical contexts; even historical texts are thus subject to reading and criticism over time. This article discusses the posthumous fate of Henry Stubbe’s own text on Islamic history, The Rise and Progress of Mahometanism—seen by some to represent a Copernican revolution in the study of Islam. The fate of this work is a clear example of the critical contingencies and fluctuating fortunes experienced by a corpus of texts. The continuing existence of a text as an object open to reconfiguration and re-evaluation is termed its after-history (Nachgeschichte) or afterlife (Nachleben). This notion of the afterlife of an object as a period of critical appreciation and political appropriation aptly defines the fate and fame of The Rise and Progress of Mahometanism. The present study seeks to explore the narrative surrounding a publication authored by Stubbe in the 17th century and finally published by Hafiz Mahmud Khan Shairani, with the critical support of Ottoman intellectual Halil Halid Bey, nearly two centuries later. Its objective is to investigate how the life and contributions of a figure whose work has transcended generations was resurrected within the political backdrop of the 20th century, as evidenced in the columns of Ottoman newspapers.
Pre-Launch Polarization Assessment of JPSS-3 and -4 VIIRS VNIR Bands and Comparison with Previous Builds
Authors: Moyer David , McIntire Jeff , Angal Amit , Xiong Xiaoxiong
Published: June 2024

The Visible Infrared Imaging Radiometer Suite (VIIRS) instrument, deployed on multiple satellites including the Suomi National Polar-orbiting Partnership (S-NPP), National Oceanic and Atmospheric Administration 20 (NOAA-20), NOAA-21, Joint Polar Satellite System (JPSS-3), and JPSS-4 spacecraft, with launches in 2011, 2017, 2022, 2032, and 2027, respectively, has polarization sensitivity that affects the at-aperture radiometric Sensor Data Record (SDR) calibration in the Visible Near InfraRed (VNIR) spectral region. These SDRs are key inputs into the VIIRS atmospheric, land, and water Environmental Data Records (EDRs) that are integral to weather and climate applications. If the polarization sensitivity of the VIIRS instrument is left uncorrected, EDR quality will degrade, causing diminished quality of weather and climate data. Pre-launch characterization of the instrument’s polarization sensitivity was performed to mitigate this on-orbit calibration effect and improve the quality of the EDRs. Specialized ground test equipment, built specifically for the VIIRS instrument, enabled high-fidelity characterization of the instrument’s polarization performance. This paper will discuss the polarization sensitivity characterization test approach, methodology, and results for the JPSS-3 and -4 builds. This includes a description of the ground test equipment, instrument requirements, and how the testing was executed and analyzed. A comparison of the polarization sensitivity results of the on-orbit S-NPP, NOAA-20, and -21 instruments with the JPSS-3 and -4 VIIRS instruments will be discussed as well.
A First Look at Internal Waves in the Great Barrier Reef Lagoon
Authors: Marmorino George
Published: June 2024

The Great Barrier Reef lagoon is a large, relatively shallow area of the Australian continental shelf, isolated from the open ocean by a dense matrix of coral reefs. As the lagoon is generally vertically well mixed by strong tidal currents and wind, it is perhaps not surprising there is no mention in the open literature of the occurrence of internal waves there. Nevertheless, high-resolution satellite imagery is shown in this article to reveal the characteristic surface expressions of nonlinear internal waves in the lagoon. The waves are confined to periods of low winds in austral spring and summer, making them a potentially important mechanism for the dispersal of algae and planktonic larvae. The imagery suggests a link between the waves and tidally forced submesoscale jets and vortices, but the actual mechanism generating the internal waves is unclear and requires investigation.
Non-Destructive Monitoring of Peanut Leaf Area Index by Combing UAV Spectral and Textural Characteristics
Authors: Qiao Dan , Yang Juntao , Bai Bo , Li Guowei , Wang Jianguo , Li Zhenhai , Liu Jincheng , Liu Jiayin
Published: June 2024

The leaf area index (LAI) is a crucial metric for indicating crop development in the field, essential for both research and the practical implementation of precision agriculture. Unmanned aerial vehicles (UAVs) are widely used for monitoring crop growth due to their rapid, repetitive capture ability and cost-effectiveness. Therefore, we developed a non-destructive monitoring method for peanut LAI, combining UAV vegetation indices (VI) and texture features (TF). Field experiments were conducted to capture multispectral imagery of peanut crops. Based on these data, an optimal regression model was constructed to estimate LAI. The initial computation involves determining the potential spectral and textural characteristics. Subsequently, a comprehensive correlation study between these features and peanut LAI is conducted using Pearson’s product component correlation and recursive feature elimination. Six regression models, including univariate linear regression, support vector regression, ridge regression, decision tree regression, partial least squares regression, and random forest regression, are used to determine the optimal LAI estimation. The following results are observed: (1) Vegetation indices exhibit greater correlation with LAI than texture characteristics. (2) The choice of GLCM parameters for texture features impacts estimation accuracy. Generally, smaller moving window sizes and higher grayscale quantization levels yield more accurate peanut LAI estimations. (3) The SVR model using both VI and TF offers the utmost precision, significantly improving accuracy (R2 = 0.867, RMSE = 0.491). Combining VI and TF enhances LAI estimation by 0.055 (VI) and 0.541 (TF), reducing RMSE by 0.093 (VI) and 0.616 (TF). The findings highlight the significant improvement in peanut LAI estimation accuracy achieved by integrating spectral and textural characteristics with appropriate parameters. These insights offer valuable guidance for monitoring peanut growth.
Estimation of Chlorophyll Content in Apple Leaves Infected with Mosaic Disease by Combining Spectral and Textural Information Using Hyperspectral Images
Authors: Song Zhenghua , Liu Yanfu , Yu Junru , Guo Yiming , Jiang Danyao , Zhang Yu , Guo Zheng , Chang Qingrui
Published: June 2024

Leaf chlorophyll content (LCC) is an important indicator of plant nutritional status and can be a guide for plant disease diagnosis. In this study, we took apple leaves infected with mosaic disease as a research object and extracted two types of information on spectral and textural features from hyperspectral images, with a view to realizing non-destructive detection of LCC. First, the collected hyperspectral images were preprocessed and spectral reflectance was extracted in the region of interest. Subsequently, we used the successive projections algorithm (SPA) to select the optimal wavelengths (OWs) and extracted eight basic textural features using the gray-level co-occurrence matrix (GLCM). In addition, composite spectral and textural metrics, including vegetation indices (VIs), normalized difference texture indices (NDTIs), difference texture indices (DTIs), and ratio texture indices (RTIs) were calculated. Third, we applied the maximal information coefficient (MIC) algorithm to select significant VIs and basic textures, as well as the tandem method was used to fuse the spectral and textural features. Finally, we employ support vector regression (SVR), backpropagation neural network (BPNN), and K-nearest neighbors regression (KNNR) methods to explore the efficacy of single and combined feature models for estimating LCC. The results showed that the VIs model (R2 = 0.8532, RMSE = 2.1444, RPD = 2.6179) and the NDTIs model (R2 = 0.7927, RMSE = 2.7453, RPD = 2.2032) achieved the best results among the single feature models for spectra and texture, respectively. However, textural features generally exhibit inferior regression performance compared to spectral features and are unsuitable for standalone applications. Combining textural and spectral information can potentially improve the single feature models. Specifically, when combining NDTIs with VIs as input parameters, three machine learning models outperform the best single feature model. Ultimately, SVR achieves the highest performance among the LCC regression models (R2 = 0.8665, RMSE = 1.8871, RPD = 2.7454). This study reveals that combining textural and spectral information improves the quantitative detection of LCC in apple leaves infected with mosaic disease, leading to higher estimation accuracy.
Self-Calibration Strip Bundle Adjustment of High-Resolution Satellite Imagery
Authors: Zhang Xue , Pan Hongbo , Zhou Shun , Zhu Xiaoyong
Published: June 2024

The attitude accuracy of high-resolution satellite images is the main factor affecting their geometric positioning accuracy. Bundle block adjustment is the main method for realizing the simultaneous estimation of attitude models for overlapping images over a large area. In the current research on the joint positioning of high-resolution multi-line array satellite images, the adjustment is usually carried out with the view or load as a unit without considering the consistency of the error of the same platform. In this paper, we develop a self-calibration strip bundle adjustment scheme that considers the boresight misalignment among multiple cameras. By introducing the installation angle between multiple loads, we fully utilized their geometric constraint relationship with the same platform to establish a unified attitude compensation model for multiple loads. The experimental results of the ZiYuan3 (ZY-3) satellite image show that, when the ground control points (GCPs) are laid only at four corner points of the image, the image plane and elevation accuracies are 1.85 m and 1.87 m after an adjustment using this method, which can achieve comparable accuracies with those obtained by a traditional program based on an adjustment with more GCPs.
Contribution from the Western Pacific Subtropical High Index to a Deep Learning Typhoon Rainfall Forecast Model
Authors: Fang Zhou , Cheung Kevin K. W. , Yang Yuanjian
Published: June 2024

In this study, a tropical cyclone or typhoon rainfall forecast model based on Random Forest is developed to forecast the daily rainfall at 133 weather stations in China. The input factors to the model training process include rainfall observations during 1960–2018, typhoon information (position and intensity), station information (position and altitude), and properties of the western Pacific subtropical high. Model evaluation shows that besides the distance between a station and cyclone, the subtropical high properties are ranked very high in the model’s feature importance, especially the subtropical ridgeline, and intensity. These aspects of the subtropical high influence the location and timing of typhoon landfall. The forecast model has a correlation coefficient of about 0.73, an Index of Agreement of nearly 0.8, and a mean bias of 1.28 mm based on the training dataset. Biases are consistently low, with both positive and negative signs, for target stations in the outer rainband (up to 1000 km, beyond which the model does not forecast) of typhoons. The range of biases is much larger for target stations in the inner-core (0–200 km) region. In this region, the model mostly overestimates (underestimates) the small (large) rain rates. Cases study of Typhoon Doksuri and Talim in 2023, as independent cases, shows the high performance of the model in forecasting the peak rain rates and timing of their occurrence of the two impactful typhoons.
Colorimetric Evaluation of a Reintegration via Spectral Imaging—Case Study: Nasrid Tiling Panel from the Alhambra of Granada (Spain)
Authors: Martínez-Domingo Miguel Ángel , López-Baldomero Ana Belén , Tejada-Casado Maria , Melgosa Manuel , Collado-Montero Francisco José
Published: June 2024

Color reintegration is a restoration treatment that involves applying paint or colored plaster to an object of cultural heritage to facilitate its perception and understanding. This study examines the impact of lighting on the visual appearance of one such restored piece: a tiled skirting panel from the Nasrid period (1238–1492), permanently on display at the Museum of the Alhambra (Spain). Spectral images in the range of 380–1080 nm were obtained using a hyperspectral image scanner. CIELAB and CIEDE2000 color coordinates at each pixel were computed assuming the CIE 1931 standard colorimetric observer and considering ten relevant illuminants proposed by the International Commission on Illumination (CIE): D65 plus nine white LEDs. Four main hues (blue, green, yellow, and black) can be distinguished in the original and reintegrated areas. For each hue, mean color difference from the mean (MCDM), CIEDE2000 average distances, volumes, and overlapping volumes were computed in the CIELAB space by comparing the original and the reintegrated zones. The study reveals noticeable average color differences between the original and reintegrated areas within tiles: 6.0 and 4.7 CIEDE2000 units for the yellow and blue tiles (with MCDM values of 3.7 and 4.5 and 5.8 and 7.2, respectively), and 16.6 and 17.8 CIEDE2000 units for the black and green tiles (with MCDM values of 13.2 and 12.2 and 10.9 and 11.3, respectively). The overlapping volume of CIELAB clouds of points corresponding to the original and reintegrated areas ranges from 35% to 50%, indicating that these areas would be perceived as different by observers with normal color vision for all four tiles. However, average color differences between the original and reintegrated areas changed with the tested illuminants by less than 2.6 CIEDE2000 units. Our current methodology provides useful quantitative results for evaluation of the color appearance of a reintegrated area under different light sources, helping curators and museum professionals to choose optimal lighting.
An Innovative EEG-Based Pain Identification and Quantification: A Pilot Study
Authors: Segning Colince Meli , da Silva Rubens A. , Ngomo Suzy
Published: June 2024

Objective: The present pilot study aimed to propose an innovative scale-independent measure based on electroencephalographic (EEG) signals for the identification and quantification of the magnitude of chronic pain. Methods: EEG data were collected from three groups of participants at rest: seven healthy participants with pain, 15 healthy participants submitted to thermal pain, and 66 participants living with chronic pain. Every 30 s, the pain intensity score felt by the participant was also recorded. Electrodes positioned in the contralateral motor region were of interest. After EEG preprocessing, a complex analytical signal was obtained using Hilbert transform, and the upper envelope of the EEG signal was extracted. The average coefficient of variation of the upper envelope of the signal was then calculated for the beta (13–30 Hz) band and proposed as a new EEG-based indicator, namely Piqβ, to identify and quantify pain. Main results: The main results are as follows: (1) A Piqβ threshold at 10%, that is, Piqβ ≥ 10%, indicates the presence of pain, and (2) the higher the Piqβ (%), the higher the extent of pain. Conclusions: This finding indicates that Piqβ can objectively identify and quantify pain in a population living with chronic pain. This new EEG-based indicator can be used for objective pain assessment based on the neurophysiological body response to pain. Significance: Objective pain assessment is a valuable decision-making aid and an important contribution to pain management and monitoring.