bluuebunny/crossref_metadata_2025 huggingface dataset:
Biogenic Nanomaterials: A Way Forward in Preventing Bacterial Infections
Authors: Maham Khan  , Shahid Wahab  , Haroon Muhammad Ali  , Sadia Khan  , Reema Iqbal  , Tariq Khan
Published: March 2023

Antibiotic resistance puts a tremendous strain on the healthcare system. Bacteria such as Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa that cause diseases like endocarditis, pneumonia, and Urinary tract infections have now become resistant to many previously used antibiotics. Antibiotic overuse must be reduced as it has become a public health threat paving the way to pandemics. Instead of creating new antibiotics, repurposing existing medicines that have faced resistance is one way forward. Plant-based antimicrobials have been explored as antibiotics to boost or augment the capability of existing antibiotics. It has been proposed that conjugates of plant-based products and antibiotics have increased activity and that the conjugated groups could help circumvent the beta-lactam antibiotic resistance mechanisms. Antibiotics have been combined with plant-based substances like Berberine, and a considerable synergy has been reported among them. Nanomaterials also promise a powerful environment-friendly strategy for weaponizing antibiotics with plant compounds. Nanoparticles could attach with many biological molecules such as DNA, enzymes, ribosomes, and lysosomes, further affecting the permeability of the cell membrane. The interaction of nanoparticles with many biological targets makes it hard for bacteria to develop resistance against them. Low molecular weight nanomaterial based on antibiotics could be very effective against multidrug-resistant gram-negative pathogens. Our study aims to analyze the progress done at the front of nanomaterials and nano-antibiotics against infectious diseases.
Associative Fields of the Composites with the Components of Covid- and Corona- in Bulgarian and Polish Language Awareness
Authors:   Sofia University Faculty of Journalism and Mass Communication, Eftimova Andreana , Długosz Natalia ,   Adam Mickiewicz University of Poznań Institute of Slavic Phililogy
Published: March 2023

t. This text presents a part of a complex study involving several experiments. Here, the results of the associative experiment are analyzed, the aim of which is to establish the associative field and the semantic structure of three pairs of composites with covid- and corona- in Bulgarian and Polish: kovidturism and koronaturystyka, kovidkupon and koronaparty, koronapanika and koronapanika, by outlining the attitudes towards the concepts they denote. The results of the associative experiment show that the studied words are fixed in the linguistic consciousness of the Bulgarian and Polish respondents with a certain variability of the semantic structure due to the high dispersion of the reactions. The associative cores of the same associations given by Bulgarian and Polish respondents show differences, with the concentration of responses in the Polish associative core being higher. This proves a more firmly established meaning of compositums in the Polish linguistic consciousness. It is obvious that social experience and practices influence the formation of the image of the concepts and the construction of the meaning of the composites with the first component covid- and corona- in both languages, and these processes are not yet complete.
A Chronicle of Bulgarian Dignit (Yulia Nikolova. Fathers and Sons. A Branch of Svishtov’s Shishman Family Tree)
Authors:   Department of Bulgarian Literature and Literary Theory, Paisii Hilendarski University of Plovdiv, Getova Elena
Published: March 2023

The present text reviews the newest book by the authoritative researcher of Bulgarian literature of the Revival period and longtime lecturer at Paisii Hilendarski University of Plovdiv – Associate Professor Yulia Nikolova, PhD. Her book, titled Fathers and Sons. A Branch of Svishtov’s Shishman Family Tree, is dedicated to the 160-th anniversary of the birth of Professor Ivan Shishmanov. The study teases out not only the life of the famous researcher and politician, but also the lives of his father, Dimitar Emanuilov Shishmanov, and his son, Ivan Dimitrov Shishmanov. The review focuses on a few key topics from the book, discusses the newly uncovered archive papers the author presents, and comments on the original contributions of the study.
New Studies Devoted to the Ontology of Status Situations in the Bulgarian and Russian Languages
Authors:   Sofia University, Department of Bulgarian Language, Alexova Krasimira
Published: March 2023

This review presents the results of a Bulgarian-Russian project in the field of status situations in the Bulgarian and Russian languages. The monograph, the work of the scientific team, is also presented, emphasizing the main contributions of the individual studies.
Tensile strenght of a dental cement based on copaíba oil-resin
Authors: Lima Cássia Cunha de , Souza Tatiane Pereira de , Conde Nikeila de Oliveira , Toda Carina
Published: March 2023

This study aimed was  to compare the tensile strength of a dental cement based on copaiba resin-oil with the temporary cement RelyX Temp NE (3M, Sumaré-SP, Brazil) in bisacrylic resin crowns. Ten human third molars ,standardized prepared to total crowns, recived temporary crowns cemented with the copaiba cement and  the others ten with RelyX Temp NE (3M, Sumaré-SP,Brazil). The twenty samples passed by twenty-four hours immersed in artificial saliva, and then the crowns were tractioned in a universal testing machine at 1.0 mm/min. The crowns cemented with copaiba  resin-oil showed tensile strength statistically higher when compared to those cemented with RelyX Temp NE (3M, Sumaré-SP,Brazil).
Indole butyric acid in the rooting of physalis cutting
Authors: Sandoval Paixão Marcus Vinicius , Cremonini Gustavo Miranda , Fernandes Antonio Resende , Reis Lucilea Silva dos , Oliveira Ednaldo Miranda de
Published: March 2023

Physalis angulata L. grows as a wild plant in tropical areas of America, its center of origin being undetermined, it is believed that the plant originated in South American countries. In propagation by cuttings, auxins are necessary for the formation of adventitious roots. The objective was to evaluate different dosages of IBA in the rooting development of Physalis cuttings. Apical herbaceous cuttings of Physalis with 10 cm in size were used, submitting them in basal contact in a mixture of IBA with talc in the concentrations: 1000 mg.Kg-1, 2000 mg.Kg-1, 3000 mg.Kg-1 and 4000 mg.Kg-1, and untreated cuttings as a control, staked in tubes with a capacity of 200 mL with substrate soil + sand (2:1), in mini greenhouses with intermittent nebulization. The experimental design was in randomized blocks (DBC), with 5 treatments in four replications, with each experimental unit composed of 10 cuttings. After 60 days from the beginning of rooting, the percentage of rooting was evaluated; bud length; root length; green and dry mass of leaves; green and dry mass of roots. IBA improved rooting and development of Physalis angulata L.
Prospective cohort study of the venous system through duplex mapping in the puerperal pregnancy cycle
Authors: Ferreira Bernardi Felipe , Silva Jean Carl , Dantas Luiza Andraus , Vieira Maria Julia Doin , Carvalho Milena , Oliveira Antonia Aparecida Deluca de
Published: March 2023

Objective: To evaluate the changes in the venous system during pregnancy and childbirth in pregnant and postpartum women without previous venous disease. Methods: This is an observational, analytical prospective cohort study carried out from May 2021 to October 2021, in pregnant women undergoing caesarean section on their first postoperative day, with duplex mapping being performed to assess the diameter and reflux of the great and small saphenous veins, mean venous flow velocity in the common femoral veins in dorsal decubitus and the comparison of velocities when adopting the left and right lateral decubitus position before caesarean section and on the first postpartum day. Result: 49 pregnant women were evaluated, and an increase in flow velocity was observed when adopting the right and left lateral positions in relation to pre- and post-cesarean section in dorsal decubitus. The mean velocity of venous flow from the common femoral vein increased in the postpartum period, regardless of the decubitus adopted. Conclusion: There was an improvement in flow in the femoral vein with the change from dorsal decubitus to right and left lateral decubitus and after termination of pregnancy.
Analysis of the final disposal of solid waste from the municipalities that make up the territory of Costa do Descobrimento Identity
Authors: Santos Fernando , Queiroz Abílio , Santo Fábio , Araújo Narcísio
Published: March 2023

The inadequate disposal of solid waste can be a practice that maximizes environmental degradation. Given the above, the present work aimed to analyze the final disposal of urban solid waste in the municipalities that are part of the Território de Identidade Costa do Descobrimento, in Bahia. The first step was the research on specialized official platforms and websites and the literature review of scientific articles. In the second stage, the Municipalities were contacted. With the exception of the Municipalities of Belmonte and Porto Seguro, the works analyzed showed a predominance of the use of open dumps. It was possible to notice a variation in the use of some terminologies. The city halls of the municipalities did not return contact, which made it impossible to access information that was not found on the platforms and in the analyzed scientific literature. It is recommended that city halls fill in the official platforms, thus avoiding the information gap, as well as studying the feasibility of creating consortiums among those who are interested in disposing of waste as recommended by the PNRS, thus preventing the impacts negative environmental influences continue to exert influences in the municipalities studied.
An overview of public health implications of mycotoxins contamination of maize and guinea corn from markets in Kogi State, Nigeria
Authors: Babatunde Gabriel Olorunnado  , Felix Enemaku Ojade
Published: March 2023

Maize and guinea corn being one of the most important staple in Nigeria were evaluated for their mycotoxins contents., 20 samples of maize and 20 sample of guinea corn ( 10 samples collected from the markets and 10 samples collected from the ware house) were obtained from three different senatorial zone of Kogi State. A total of 30 samples of maize and 30 samples of guinea corn collected from the three zones of Kogi state were analyzed for the presence of Aflatoxin B1, AflatoxinB2, Fumonisin, Ochratoxin A, and Zearalenone. The result revealed the presence of the studied mycotoxins in 67 % of all the 60 samples. The results also revealed the presence of mycotoxins in 80 % of the 15 maize samples picked from the market and 73 % of the 15 maize samples picked from the ware house in the three senatorial zone. Also the percentage composition of all the mycotoxins present in the 30 samples of guinea corn was 67% of the 15 samples picked from the markets and 47% of the 15 samples picked from the ware house respectively. Among all the studied mycotoxins, only fumonisin have its concentration above the recommended limit approved by the Joint Expert Committee on Food Additives of the WHO and FAO (JECFA). The concentration of the remaining mycotoxins under study is nothing to be worried about but, adequate measure should be taken to checkmate the conditions that expose the food crops to the growth of fungi.
TAFSIR INDONESIA (Studi Kritis atas Tafsir Basmalah karya Kyai Asmuni)
Authors: Bahary Ansor , Fitroni Komaruddin
Published: March 2023

When the mufasir interprets Bismillāh al-Raḥmān al-Raḥīm into a work of interpretation, the understanding and meaning produced is generally based on prayer and the relation of fā‘idah isti’ānah (asking for help like a servant to His Lord) usually other interpretations. This output is caused by the fact that basmalah is interpreted in its entirety, without specifying the interpretation of the sentences in it, or it may be detailed but not upproached with grammatical-arabic discourse. Slightly different from the interpretation carried out by Kyai Asmuni, it does not only focus on this but raises at least three scientific domains such as theology (al-’aqīdah), fiqh (al-h}ukm), and sufism (al-akhlāq). Even at the same time, this realm can also became an icon of its interpretation style and at the same time demarcate it from other interpretaions. Understanding and meaning of this religious trilogy was originally explored by the author through his meditation on the basics and bases such as writing lafal (kitābah), reading (qira‘at), language (lughah), syintax (nahwu), literature (balāghah), and logic (mantiq) in the context of reading “ba”, “ism”, jalalah “Allah” and “al-Rahman al-Rahim”.
Economía y sociedad en APEC: Transiciones poscovid-19
Authors: Zottele Allende Anibal Carlos , Robles Sámano María Guadalupe , Gómez Aguirre Mario , Herrera Gómez Itzel Abigaíl , Marín Leyva René Augusto , Rodríguez José Carlos , Licona Michel Angel , González García Juan , Polanco Gaytán Mayrén , Torres Preciado Victor Hugo , Ivanova Boncheva Antonina , Gámez Vázquez Elba Eritrea , Torres García Alberto Francisco , Gil Altamirano Bárbara , Becerra Chirón Iskra Mariana , Cuevas Tello Ana Bertha , Preciado Caballero Nora Elena , Gaytán Gómez Oriana Zaret , Zamora Torres América Ivonne ,   Consorcio Mexicano de Centros de Estudios APEC
Published: March 2023

Las múltiples transiciones hacia un escenario poscovid-19 marcan la agenda reciente de APEC. Si bien, la liberación comercial y la disminución de las barreras que impiden la Inversión Extranjera Directa en las economías de APEC siguen siendo temas prioritarios en la agenda de este mecanismo de cooperación, estos temas no son los únicos que se debaten al interior de APEC, ni son los mismos, de acuerdo con el contexto que operan. La complejidad del mundo y los retos que enfrenta la humanidad se reflejan en las prioridades, objetivos y planes de acción que desde APEC se proponen, bajo el espíritu del regionalismo abierto, con la intención de crear las condiciones que permitan un desarrollo sostenible. APEC impulsa una serie de propuestas con la intención de generar las condiciones para un desarrollo equilibrado y sostenible, que permita la inclusión, abata la brecha de género y limite o reduzca los efectos negativos que se generan al medio ambiente derivados de las actividades económicas. A su vez, invita a pensar en planes de acción para mejorar la conectividad en todas sus formas e impulsar la innovación, la ciencia y la tecnología. Este libro ofrece una serie de reflexiones desde una perspectiva multidisciplinar sobre los desafíos de APEC en el contexto de un mundo enmarcado por las complejas transiciones poscovid-19.
PubCast - “Nature’s Little Helpers”: A benefits approach to voluntary cultivation of hatchery fish to support wild Atlantic salmon (Salmo salar) populations in Norway, Wales, and Germany
Authors: Harrison Hannah L.
Published: March 2023

Fish hatcheries have received a lot of criticism in recent years over concerns that rearing and releasing fish from hatcheries may have negative impacts on wild fish populations. Yet, many local-level stakeholder groups, such as anglers, continue to support the use of hatcheries as a means of conserving declining wild fish stocks, particularly for Atlantic salmon. Could it be that their interest and support of hatcheries is about more than the fish they produce? In this paper, we explore the different kinds of social, psychological, and conservation benefits produced by hatcheries in three European case studies.

This article was originally published in Fisheries Research.

This paper was authored by Hannah L Harrison, Sophia Kochalski, Robert Arlinghaus, and Øystein Aas.
PubCast - Seeing Beneath Disputes
Authors: Harrison Hannah L. , Loring Philip
Published: March 2023

Conservation conflicts are pressing social and environmental sustainability issues, and the complex underlying causes and escalating factors of such conflicts can often be difficult to understand. This article synthesizes a breadth of conservation conflict literature to lay out a transdisciplinary framework for diagnosing complex conservation conflicts composed of six key aspects: complexity, emergence, and stages; conflict status; basis of contention and cognitive framing; state of knowledge; state of values; and interventions. This framework is based in systems thinking and encourages users to harness thinking based in storytelling and consider how a conservation conflict represents a larger ongoing narrative with depth, meaning, and containing complex, interrelated storylines.

This paper was authored by Hannah L. Harrison and Philip A. Loring.

This paper was originally published in Biological Conservation.
Gender Preselection in the Buffalo Species (Bubalus Bubalis): Preliminary Data on Different Strategies and Pregnancy Outcome
Authors: A Presicce Giorgio
Published: March 2023

In this study, a new comparison was tested in Mediterranean Italian buffaloes (Bubalus bubalis), between two different strategies for obtaining sperm cells of the desired sex. In addition, a control group of animals was included in the study, where only ordinary semen straws, containing unselected sper cells were used. Sexed and control straws were then used for Artificial Insemination (AI) in order to confront pregnancy and gender rates. The first of the two strategies to preselect sperm cells relies on the physical determination of DNA content in single spermatozoa though cell sorting machines. The second strategy instead, relies on the coincubation of either fresh or frozen/thawed semen with a specific solution specifically designed for the species of interest. The trial involved a total of 206 heifers and 211 pluriparous buffaloes belonging to a buffalo farm in the south of the Lazio Region in Italy. In this study, no significant differences between treated and control groups were detected in terms of pregnancy rates both on heifers (P=0.6) and pluriparous buffaloes (P=7). With regard to gender rates, pregnancy rates were significantly different among the three groups of heifers (P=0.001) and the three groups of pluriparous buffaloes (P=0.002). Sperm cells preselected for gender determination through Cell Sorting (CST) resulted effective in shifting the gender ratio towards the female, when compared to both the Coinbubation Technique (COiT) and control group of animals.
Ethics and Sustainability in The Jewellery Industry
Authors: Lin Yunzhi , Sai Na
Published: March 2023

Sustainability and ethics have never ceased to be the major concerns for the fashion industry. It plays a crucial role in influencing consumers' decisions during the process of consuming products. The jewellery industry must consider ethics and sustainable development as integral parts of its development. There are numerous industry reports and statistics that demonstrate how important sustainability is to today's young consumers. The jewellery industry is expected to exhibit a high level of commitment to environmental protection and ethical standards. Despite the fact that the non-renewable nature of mineral resources as raw materials for jewellery appears to contradict the concept of sustainability on the surface, more and more organizations and institutions within the jewellery industry are actively committed to sustainability. The purpose of this article is to gather relevant cases of jewellery brands in the industry, and analyze the current situation and future plans of the jewellery industry in terms of ethics and environmental protection, in order to provide some suggestions for future development.
The Effects of The Characteristics of Entrepreneurs on the Creation Process of SMEs
Authors: Gu Cheng
Published: March 2023

The theme of this review is to elucidate how entrepreneurial traits affect the start-up process of small and medium-sized enterprises (SMEs), which aims to learn more about the relationship between entrepreneurial characteristics and the early stages of SMEs. While most of the previous literature has focused on the mode of operation of the company, there is very little literature on the early stages of entrepreneurship in SMEs which play a vital role in the world economy. It is hoped that this review will help to provide deep insights to those who wish to start their own business. By identifying gaps in existing research and focusing on how entrepreneurial characteristics affect the start-up stage of SMEs creation, the review provides direction for future research and ideas for entrepreneurs and venture capitalists. The review finds that different types of entrepreneurs influence the future direction of an enterprise, and that entrepreneurial personality qualities and business development are positively linked. The extroversion of entrepreneurs in the Big Five personality theory makes entrepreneurs more willing to interact and collaborate with others, thus influencing the performance and growth of the start-up.
Three Main Tools for Luxury Brands to Strengthen Customers Perception of the Brand
Authors: Lin Jingzhi
Published: March 2023

The paper is mainly focusing on examining strategies for firms in the luxury goods market to increase sales. In this paper, the 3 strategies: why logos play an essential role in this industry, why traditional luxury brands began collaborating with fashionable brands and why luxury brands pay high fees to celebrities to engage them as spokespersons, are illustrated. After elaborating on these strategies along with an empirical research and screenshots, the results show that one of the reasons why people are fond of buying luxury products is that logos represent a sense of superiority and may show the owners status; collaboration draws people's attention and increases purchase desire as a large number of people appreciate the combination of luxury and street fashion; star effect leads to many customers want to follow or imitate their idols so they are likely to purchase the clothes or items which their idols have worn.
PENGALAMAN KELUARGA MENGHADAPI STIGMA MASYARAKAT PADA PENDERITA GANGGUAN JIWA
Authors: Pangandaheng Nansy Delia , Medea Gitalia , Hinonaung Jelita , Mahihody Astri
Published: March 2023

Stigma merupakan bentuk prasangka untuk menolak individu ataupun kelompok karena berbeda dengan yang lain. Seseorang yang mengalami sakit kejiwaan selalu mendapatkan perlakuan buruk dari lingkungan disekitar tempat tinggalnya. Keluarga yang merawatnya juga mendapatkan dampaknya jika memiliki anggota keluarga yang gangguan jiwa. Tujuan dari penelitian ini yaitu mengetahui bagaimana pengalaman keluarga dalam menghadapi stigma masyarakat terhadap orang dengan gangguan jiwa (ODGJ). Metode penelitian yang digunakan yaitu kualitatif dengan teknik wawancara pada enam keluarga yang berbeda tempat tinggal dan memiliki anggota keluarga yang mengalami gangguan jiwa di wilayah kerja Puskesmas Tahuna Timur. Analisia data ini menggunakan tujuh langkah Collaizi. Hasil yang didapat yaitu stigma yang buruk akan memberikan dampak kepada ODGJ dan keluarga. Dimana keluarga ikut mendapatkan dampak dari diskriminasi pada keluarga dan anggota keluarga yang sakit jiwa. Berdasarkan wawancara maka penulis menemukan 3 tema utama yaitu persepsi negatif, diskriminasi dari lingkungan sekitar dan kurangnya pengetahuan tentang gangguan jiwa.

Stigma is a prejudice to refuse someone or groups because they are different from others. Someone who has a mental illness always bad treated with stigma by around society. And will also impact on the family caring for the patient as well. The Aim of this STUDY wants to know about family experiences facing society's negative community response or stigma to someone with mental disorders. The research method is qualitative where interviewing six (6) different family patients with mental disorders in East District Tahuna Health Center. This data analysis used seven steps of collaizi and the results obtained that the bad stigma will have an impact on the patient and their family. Family members also get the impact of discrimination against mentally ill of patients too. Based on the interview method this research finds three (3) basic themes there are negative responses, discrimination by around society, and less of knowledge about mental disorders.
THE HUBUNGANiPENGETAHUANiDANiMOTIVASIiMAHASISWAiINDEKOS TERHADAPiTINDAKANiSEKSUALiPRANIKAHiDI KECAMATAN MANGANITU
Authors: Tooy Gracia Christy , Wuaten Grace Angel , Umboh Melanthon Junaedi , Tatangindatu Maryati Agustina
Published: March 2023

Seorang individu yang memasuki masa kuliah umumnya berada pada tahapan remaja akhir, yaitu berusia 18-21 tahun. Sesuai dengan karakteristik perkembangan seksualnya, siswa biasanya mengembangkan perilaku seksualnya dalam bentuk hubungan heteroseksual atau pacaran. Perilaku seksual pranikah menjadi lebih umum di kalangan mahasiswa, terutama mahasiswa indekos, yang kurang mendapat pengawasan orang tua, masyarakat, dan konseling yang seharusnya mereka terima. Tujuan penelitian ini adalah untuk mengetahui hubungan antara pengetahuan dengan motivasi tindakan seksual pranikah di tempat indekos. Jenis penelitian survei yang bersifat deskriptif analisis dengan ransangan cross-sectional. Responden penelitian adalah mahasiswa laki-laki dan perempuan usia 18-24 tahun yang tinggal di kontrakan atau kos di Kecamatan Manganitu. Instrumen dengan menggunakan kuesioner. Analisis univariat dan bivariat dengan menggunakan uji chi-square. Hasil tidak ada hubungan yang bermakna antara pengetahuan dan motivasi dengan tindakan seksual pranikah. Kesimpulan pada pengetahuan dan motivasi H0 diterima sedangkan H1 ditolak.

An individual person who enters a college is generally in a late teenager stage, which is 18-21 years old. According to the characteristics of their sexual development, students generally have developed their sexual behavior in the form of heterosexual relationships or dating. Premarital sexual behavior has become lively among college students, especially boarding students who have minimal parental control, society and the guidance they should receive. The purpose of this study was to determine relationship between knowledge and motivation of boarding students towards sexual acts. The type of this survey research is descriptive analytic study using a cross-sectional design. The research respondents were male and female students aged 18 to 24 years old who lived in rented or boarding house in Manganitu District. The instrument  for data collection was using a questionnaire form. Data were analysis using univariate and bivariate of the chi-square test. The results show there were no significant relationship between knowledge and motivation with premarital sexual acts, moreover these were in acccordance with acceptance of H0.
Дифракционные поля и поля зарядов, выраженные через Вектор Герца в электродинамике
Authors:   Ереванский государственный университет, Ереван, Армения, Балян М. К.
Published: March 2023

In the first part of this work, using the found vector Green's function, the electromagnetic fields in an arbitrary chosen volume are presented in vector form using surface and volume integrals, at that the surface integrals describe the diffraction of the field of charges external to the volume, and the volume integrals describe the fields of the charges, moving within the volume. For the Green's function, one of the two found forms was used. In this work, expressions for the electromagnetic fields are obtained using the second form of the found Green's function. When using the second form of the vector Green's function, the fields of charges moving inside the volume are expressed in terms of the generalized Hertz vector. The expressions obtained in this work have their advantages for determining the fields in a selected volume.
Investigation of the Causes and Ways of Reducing Injuries in Age-Related Patients with Multimorbidity
Authors: Ratushnaya Lada , Gabelaia Diana , Petrova Sofia , Maksimenko Tatiana , Barinov Sergey , Markov Alexander
Published: March 2023

The article investigates the causes and ways to reduce injuries in age-related patients with multimorbidity. The author
points out that Multimorbid people are at significant risk of falls. These results require prioritization of falls as a
public health problem with the need to integrate falls into existing geriatric healthcare programs. The combination
of multimorbidity and proximal fracture leads to an increase in mortality, which strongly indicates the need for more
comprehensive approaches to high-risk patients. Accordingly, there is a need for future research on the care of high-risk
patients after a fracture and the study of the relationship between multimorbid clusters and other signaling events in
the field of healthcare.
Seroprevalence of hepatitis B, hepatitis C, and human immunodeficiency virus in hemophilia A patients: A descriptive study
Authors: Thankamony Drisya , P Meenu , C Usha
Published: March 2023

Background: Hemophilia A (Factor VIII deficiency) is a X-linked coagulopathy that affects approximately 1/10,000 male live births. In the past, the treatment of hemophilia A consisted of cryoprecipitated plasma and purified factor preparations. As a result, they experienced unusually high incidence of hepatitis and human immunodeficiency virus (HIV) seroconversion.

Aims and Objectives: The aims of this study were to find out the seroprevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV infection, among hemophiliacs attending a tertiary care center in Kerala, southern India.

Materials and Methods: A cross-sectional study was conducted on hemophilia A patients who attended the departments of medicine and pediatrics. Demographic details and treatment history were obtained by questionnaire. Enzyme-linked immunosorbent assay was used to detect HBV surface antigen, HCV antibodies, and HIV. The statistical data analysis was performed using SPSS software version.

Results: Out of 90 hemophilia A patients who underwent testing for the seroprevalence of transfusion-transmitted viral infections, one (1.1%) patient tested positive for HIV, two (2.2%) for HCV, and one (1.1%) for HBV. Among patients with hemophilia A, the prevalence of transfusion-transmitted infection was 4.4%. Patients with HIV- and HCV-positive tests belonged to the severe hemophilia A group. Moreover, the HBV-positive patient belonged to moderate hemophilia A.

Conclusion: The present paradigm of management of hemophilia A patients is with plasma-derived or recombinant Factor VIII concentrates, cryoprecipitates, and fresh frozen plasma. Due to the risk, however remote, of transfusion-transmitted viral infections, all hemophiliacs should receive the hepatitis B vaccine and undergo routine testing for HIV, HCV, and HBV viruses.
Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study
Authors: Brattiya Keerthana , Jagdish Remya , Ahamed Ayisha , R Anuradha , J Jeyasudha
Published: March 2023

Background: Solanum xanthocarpum grows in parts of India as a wild herb. The active principles of this plant are Solasodine, Carpesterol, β-Sitosterol, and Diosgenin. Pharmacological effects such as hypoglycemic, hepatoprotective and hypotensive activity of S. xanthocarpum have been reported. Solasodine, an active component of this plant is reported to have antioxidant activity.

Aims and Objectives: The objective of this study is to evaluate the anticancer and anti-obesity property of S. xanthocarpum.

Materials and Methods: This study was carried out in Department of Pharmacology, Government Kilpauk Medical College, with laboratory support from Life Teck Research Center, Chennai. Both dry and fresh leaves of S. xanthocarpum were taken and evaluated for anticancer property using MCF cell line and anti-obesity activity using Pancreatic Lipase inhibition activity.

Results: There was significant decrease in cell viability with increase in concentration of both dry and fresh leaves which shows anticancer activity. With increase in concentrations of leaf extracts, the inhibition of pancreatic lipase was found but in comparison to Orlistat the standard treatment, the effect was very less.

Conclusion: Based on above results, it is concluded that S. xanthocarpum has good anticancer and minimal anti-obesity activity. Further investigations are required to identify the actual phytoactive component.
Antifungal drugs prescription pattern in a tertiary care teaching hospital in South India
Authors: A Subashree , R Anuradha , R Reena
Published: March 2023

Background: Fungal infections are a major threat to human health. Immunocompromised patients are more susceptible to fungal infections which may be from superficial to systemic fungal infections. Proper diagnosis and appropriate prescription is essential for management of these fungal infections. Inappropriate use of antifungal agents can lead to antifungal resistance and adverse effects caused by them. Therefore, this study was carried out to understand the prescription pattern of antifungal drugs among patients from various departments such as general medicine, dermatology, obstetrics, and gynaecology at a tertiary care hospital in South India.

Aims and Objectives: The objectives of the study are as follows: (i) To understand the Antifungal prescription practices in our hospital and (ii) to improve the rational use of antifungal drugs.

Materials and Methods: This was an observational and cross-sectional study. Inpatients and outpatients of age above 18 years attending Government Omandurar Medical College, Chennai, during the study period of 2 months who were prescribed antifungal drugs were included in this study. The prescriptions of 342 patients were collected and data including age, gender, diagnosis, name of the antifungal drugs, route of administration, dosage form, and duration of treatment were reviewed. Out of 342 prescriptions, 92 contained more than one antifungal drugs in their prescriptions. The data collected were analyzed for frequency of antifungal drugs prescription and percentage values calculated.

Results: In our study, females (n = 198; 57.95%) were prescribed antifungal drugs more than males. Most of them are out patients from the age group of 31–50 years (n = 159; 46.49%). Dermatology (n = 272; 79.53%) department had the most number of antifungal prescriptions. Tinea corporis (n = 138; 40.35%) was the most common fungal infection to be prescribed. Clotrimazole (n = 115; 27.89%) was the most commonly prescribed antifungal drug followed by Fluconazole (n = 105; 24.19%). Topical route (n = 268; 61.75%) was the most common route of administration of antifungal drugs followed by oral and parental routes, respectively.

Conclusion: This study report helped us to analyze the prescribing pattern of antifungal drugs in our tertiary care hospital. This gave an idea to create guidelines for the rational use of antifungal drugs in our institution.
Evaluation of TURP specimen with special reference to prostatic intraepithelial neoplasia and prostatic cancer using light microscopy and immunohistochemical markers of P63, CK5/6, AMACR (p504s), and PSA
Authors: Khatun Rojina , Nag Dipanwita , Saha Ipsita
Published: March 2023

Background: Prostate cancer is the world’s leading cause of cancer and the second cause of cancer-related death in men after lung cancer. The incidence of prostatic carcinoma is increasing with age. Prostate intraepithelial neoplasia can only be diagnosed by histopathological examination of prostate tissue. In practice, small foci of cancer and several morphological mimickers of different Gleason Grades were encountered leading to diagnosing difficulty. To overcome this pitfall, the use of HMW Cytokeratin’s 5 and 6 (CK5/6) or p63 or combination of these two with alpha-methyl acyl- COA-racemase (AMACR) is triple cocktail which is recommended.

Aims and Objectives: The objectives of this study were to analyze the histomorphology of various non-neoplastic and neoplastic lesions of the prostate and to know the incidence of prostatic intraepithelial neoplasia in transurethral resection of prostate (TURP) specimen, to assess the usefulness of immunohistochemical analysis with a panel of markers (p63, CK5/6, AMACR [p504s], and prostate-specific antigen [PSA]) to confirm the diagnosis of prostatic intraepithelial neoplasia and prostate cancer, and to differentiate several benign mimickers of prostatic adenocarcinoma.

Materials and Methods: It is a prospective study performed for 18 month from January 2020 to June 2021. Thirty TURP specimens were collected in 10% formalin and processed in the department of pathology, MCH, Kolkata.

Results: In the present study, benign prostatic hyperplasia formed majority of cases (80%). The presence of AMACR and absence of basal cell specific marker p63 and CK5/6 confirm the presence of prostate cancer.

Conclusion: High degree of association of HGPIN with prostatic Carcinoma, it is suggested that these HGPIN patients need close follow-up, observation, and investigation to rule out existence of carcinoma, especially in the peripheral zone.
GIBERELINA NA EMERGÊNCIA DE PLÂNTULAS DE MAMOEIRO CV. GOLDEN COM SEMENTES DE DIFERENTES IDADES
Authors: Savacini Tiago Souza , De Oliveira Virgínia Campos , Borsoi Neto Antônio Carlos , dos Santos Vitória Evangelista , Paixão Marcus Vinicius Sandoval
Published: March 2023

As sementes em geral possuem um período determinado para germinação e após este tempo passam a não serem viáveis para plantio. A giberelina é um hormônio que atua estimulando a germinação em sementes que apresentem algum bloqueio para germinar. Objetivou-se avaliar o efeito da giberelina na emergência e desenvolvimento inicial de plântulas de mamoeiro cultivar golden, com sementes de diferentes idades. Os tratamentos foram sementes com um ano, dois anos e 3 anos, armazenadas em geladeira (10°C). Duzentas sementes de cada idade foram imersas durante 60 minutos em solução de Giberelina ( , na dosagem de 2000 mg.L-1, e 200 de cada idade em água pura como testemunha, e semeadas em bandejas com substrato comercial. Após trinta dias do início da emergência, foi avaliado a porcentagem de emergência, o índice de velocidade de emergência e o tempo médio de emergência. Sessenta dias após o início da emergência foram avaliadas a altura da planta, número de folhas, diâmetro do coleto, comprimento da raiz, massa verde e seca das folhas e das raízes. Sementes de mamão armazenadas por até três anos germinam normalmente e possuem potencial para emergência quando submetidas a tratamento pré germinativo com giberelina.
CENTRALIZED MODULAR APPLICATION FOR HOTEL
Authors: Lede Vidhi , Rokde Anagha , Borkar Kajal , Nikhare Nikita , Dudhbure Prof. Omkar
Published: March 2023

The goal of this application is to overcome the drawback of traditional queuing systems. The system we propose is a medium for ordering and verifying food online without the hassle of restaurants and weighing services. This system will improve the way customers order.The system offers menus online so customers can easily order according to their preferences. Even if you have a menu, customers can easily track their orders. The system also provides a feedback system that allows users to rate the food, hotel room services and other hotel facilities. In addition, the suggestion system recom-mends hotel staff of improvements and quality. The customer can pay online or pay with cash. A separate account is maintained for each user by providing an ID and password for more secure ordering and booking. Increased global competition, consumer demand and needs, quality and quality control have become fundamental strategic factors for achieving profitability and competitiveness in the ever- changing tourism market. Key Words: Transactions, centralized, reviews, customer, admin
EXPLORING THE RELATIONSHIP BETWEEN MARUTI SUZUKI INDIA LIMITED 'S FINANCIAL STATEMENTS AND ITS STOCK PERFORMANCE
Authors: NIKHITA BAMMIDI , MOUNIKA T VEDA , SENGUPTA SUBHRA , S Dr.VINOTH
Published: March 2023

This study aims to explore the relationship between Maruti Suzuki India Limited's financial statements and its stock performance. Maruti Suzuki is a leading automobile manufacturer in India, and analyzing its financial statements can provide insights into the company's financial health, growth potential, and overall performance. The study focuses on key financial ratios that can indicate the company's financial strength and profitability, such as return on equity, operating margin, and debt-to-equity ratio. The research utilizes quantitative analysis to examine the relationship between these financial metrics and the company's stock performance. The study findings provide valuable insights for investors and analysts looking to make informed investment decisions in the automobile industry. Understanding the link between financial statements and stock performance can help investors assess the company's performance, identify potential risks, and make informed investment decisions. Keywords: Financial Analysis, Ratios, Stock Performance, Growth, Financial Position.
Carvedilol untuk Tata Laksana Clinically Significant Portal Hypertension pada Sirosis Kompensata
Authors: Sulaiman Achmad Faiz
Published: March 2023

Hipertensi portal merupakan konsekuensi klinis dari sirosis hati. Angka kematian karena hipertensi portal masih tinggi di Indonesia. Pada kondisi sirosis kompensata munculnya hipertensi portal yang signifikan secara klinis (clinically significant portal hypertension/CSPH) dapat memprediksi kejadian dekompensasi dan merupakan penanda prognosis penyakit yang lebih buruk. Diagnosis CSPH dapat dengan cara invasif ataupun non-invasif. Tata laksana CSPH pada kondisi sirosis kompensata diutamakan untuk mencegah timbulnya dekompensasi sirosis. Pemberian penghambat beta non-selektif (non-selective beta blocker/NSBB) pada kondisi sirosis kompensata efektif menurunkan hipertensi portal dan mampu mencegah dekompensasi.

Portal hypertension is a major consequences of liver cirrhosis. Mortality rate from portal hypertension is quite high in Indonesia. In patients with liver cirrhosis, the development of clinically significant portal hypertension (CSPH) is predictive for decompensation and worse prognosis. Diagnosis of CSPH can be carried out by either invasive or non-invasive methods. The aim of CSPH management in compensated cirrhosis is to prevent the incidence of decompensation. Management of compensated cirrhosis with non-selective beta blocker (NSBB) has been shown to reduce portal hypertension and the incidence of first decompensation.
Terapi Tissue Plasminogen Activator untuk Stroke Iskemik Akut
Authors: Allen
Published: March 2023

Prevalensi stroke terus meningkat setiap tahun. Penanganan kasus stroke harus dilakukan sesegera mungkin untuk memaksimalkan pemulihan serta mencegah berulang. Pada kasus stroke iskemik akut, pengobatan fibrinolitik tPA terbukti efektif. Beberapa kriteria pemberian harus dipenuhi. Pasien yang mendapat tPA harus mendapat observasi tekanan darah ketat dan memastikan tidak terjadi efek samping perdarahan. Hingga saat ini, hanya alteplase yang disetujui untuk pengobatan fibrinolitik pada pasien stroke iskemik akut. Telaah ilmiah berbasis bukti menunjukkan manfaat tPA lain. yaitu tenecteplase.

The prevalence of stroke continues to increase. To minimize brain injury, prompt management is necessary to maximize patient recovery and prevent recurrent strokes. Fibrinolytic tPA has been proven to be effective for acute ischemic stroke. Several criteria must be met before tPA administration. Patients should receive close monitoring of blood pressure and for bleeding risk. Until recently, only tPA alteplase has been approved for fibrinolytic treatment in acute ischemic stroke. Several evidence-based studies have shown the benefits of tenecteplase - another tPA - in acute ischemic stroke management.
Wie viel Trockenheit ertragen unsere Wälder? Lehren aus extremen Trockenjahren
Authors: Rigling Andreas , Etzold Sophia , Bebi Peter , Brang Peter , Ferretti Marco , Forrester David , Gärtner Holger , Gessler Arthur , Ginzler Christian , Moser Barbara , Schaub Marcus , Stroheker Sophie , Trotsiuk Volodymyr , Walthert Lorenz , Zweifel Roman , Wohlgemuth Thomas
Published: March 2023

Die Bilder grossflächig brauner Laubbäume in weiten Teilen der Schweiz sowie Zentraleuropas im Frühsommer 2018 sind uns noch sehr präsent. Diese um rund drei Monate verfrühte Herbstverfärbung der Wälder war das Resultat der extremen Hitze und langanhaltenden Dürre. Auch wenn das Ausmass und die Sichtbarkeit der Schäden in Wald und Landwirtschaft 2018 ausserordentlich waren, so stellen wir eine Häufung von solchen extremen Hitze- und Trockenjahren (2003, 2011 und 2015) fest. Laut dem neuesten Klimabericht für die Schweiz muss davon ausgegangen werden, dass Hitze- und Dürreperioden in Zukunft noch häufiger auftreten dürften. Was heisst dies nun für unsere Wälder? Wie viel Trockenheit können sie ertragen? Wir diskutieren diese Fragen anhand von Daten aus verschiedenen Monitoringansätzen und zeigen auf, dass die verschiedenen Waldökosysteme sehr unterschiedlich reagieren und die zukünftige Dynamik unserer Wälder von der Kombination und dem zeitlichen Auftreten von Trockenheit und anderen Wetterextremen abhängen wird.
steuerBAR? Wo wollen wir "Energielandschaften" und wo nicht?
Authors: Salak Boris , Kienast Felix , Olschewski Roland , Spielhofer Reto , Wissen Ulrike , Grêt-Regamey Adrienne , Hunziker Marcel
Published: March 2023

Die vorliegende Studie befasst sich mit den Präferenzen der Schweizer Bevölkerung in Bezug auf Infrastrukturen zur Produktion erneuerbarer Energie (engl. IPRE: Wind, Photovoltaik) in charakteristischen Schweizer Landschaften. Es wurde eine repräsentative Online-Panelumfrage (n = 1063) durchgeführt, die ein visuelles Entscheidungsexperiment beinhaltete. Die Ergebnisse legen nahe, dass das Vorhandensein von Energieanlagen die wahrgenommene Landschaftsqualität in den meisten Fällen reduziert, in einigen Landschaften mehr (Berggebiete abseits von Infrastrukturen,Voralpen, Jura), in anderen weniger (siedlungsgeprägtes Flachland undentsprechende Berggebiete (Alpentäler), touristisch geprägte Berggebiete). Dasgänzliche Fehlen von Photovoltaik-Infrastrukturen wird in letzteren von der Bevölkerung sogar negativ bewertet, doch eine Kombination mit Wind-Infrastrukturen kann die Beurteilung positiv beeinflussen. Der Einbezug der Bevölkerungssicht in die Planung von IPRE wird im Hinblick auf deren Akzeptanz empfohlen.
Knowledge People with Type II Diabetes about the Importance of Herbs in Lowering Blood Sugar Levels
Authors: Rashid Muna Salah
Published: March 2023

At the moment diabetes has become an epidemic disease and according to recent statistics 400 million people have diabetes in the world and it is mainly associated with developing countries, Among the huge and heterogeneous numbers type 2 diabetes (T2DM) is the most prevalent, according to the Global Burden of Diseases study for the year (2016) it was found that T2DM and its complications were responsible for increasing the percentage of disability by 22% in the last ten years.  This has greatly affected public health.
For this reason, there was a need to make a questionnaire on the knowledge of people with type 2 diabetes (T2DM) of the importance of herbs in reducing blood sugar levels, and the research included 142 samples (individuals) who were asked questions in the form of an electronic questionnaire (google form) through social networking sites (Facebook, WhatsApp, Telegram, Messenger and others) and the questionnaire included questions about diet, symptoms and concomitant diseases in addition to whether the patient is taking drugs that lower the level of sugar in the blood as well as about the use of herbs by the patient and what they are These herbs and how much they amount per day, the average amount of herbs used by the patient was one cup, and the most important herbs used were turmeric and learners and led to a decrease in the level of sugar in the blood of the patient who used them.
We conclude from this research that type II diabetes is most of its symptoms are frequent urination, thirst, slenderness, limb pain, in addition to limb neuropathy, while the diseases associated with this disease are high blood pressure, heart failure, kidney failure, visual impairment or blurred vision and other diseases.