bluuebunny/crossref_metadata_2025 huggingface dataset:
Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15
Authors: Zhao Li-Na , Guccione Ernesto , Kaldis Philipp
Published: January 2023

The PRDM family of methyltransferases has been implicated in cellular proliferation and differentiation and is deregulated in human diseases, most notably in cancer. PRDMs are related to the SET domain family of methyltransferases; however, from the 19 PRDMs only a few PRDMs with defined enzymatic activities are known. PRDM15 is an uncharacterized transcriptional regulator, with significant structural disorder and lack of defined small-molecule binding pockets. Many aspects of PRDM15 are yet unknown, including its structure, substrates, reaction mechanism, and its methylation profile. Here, we employ a series of computational approaches for an exploratory investigation of its potential substrates and reaction mechanism. Using the knowledge of PRDM9 and current knowledge of PRDM15 as basis, we tried to identify genuine substrates of PRDM15. We start from histone-based peptides and learn that the native substrates of PRDM15 may be non-histone proteins. In the future, a combination of sequence-based approaches and signature motif analysis may provide new leads. In summary, our results provide new information about the uncharacterized methyltransferase, PRDM15.
Characterization and Bioactive Potential of Secondary Metabolites Isolated from Piper sarmentosum Roxb.
Authors: Ware Ismail , Franke Katrin , Dube Mthandazo , Ali El Enshasy Hesham , Wessjohann Ludger A.
Published: January 2023

Piper sarmentosum Roxb. (Piperaceae) is a traditional medicinal plant in South-East Asian countries. The chemical investigation of leaves from this species resulted in the isolation of three previously not described compounds, namely 4″-(3-hydroxy-3-methylglutaroyl)-2″-β-D-glucopyranosyl vitexin (1), kadukoside (2), and 6-O-trans-p-coumaroyl-D-glucono-1,4-lactone (3), together with 31 known compounds. Of these known compounds, 21 compounds were isolated for the first time from P. sarmentosum. The structures were established by 1D and 2D NMR techniques and HR-ESI-MS analyses. The compounds were evaluated for their anthelmintic (Caenorhabditis elegans), antifungal (Botrytis cinerea, Septoria tritici and Phytophthora infestans), antibacterial (Aliivibrio fischeri) and cytotoxic (PC-3 and HT-29 human cancer cells lines) activities. Methyl-3-(4-methoxyphenyl)propionate (8), isoasarone (12), and trans-asarone (15) demonstrated anthelmintic activity with IC50 values between 0.9 and 2.04 mM. Kadukoside (2) was most active against S. tritici with IC50 at 5.0 µM and also induced 94% inhibition of P. infestans growth at 125 µM. Trans-asarone (15), piperolactam A (23), and dehydroformouregine (24) displayed a dose-dependent effect against B. cinerea from 1.5 to 125 µM up to more than 80% inhibition. Paprazine (19), cepharadione A (21) and piperolactam A (23) inhibited bacterial growth by more than 85% at 100 µM. Only mild cytotoxic effects were observed.
Impact of Acquisition of Digital Skills on Perceived Employability of Youth: Mediating Role of Course Quality
Authors: Kee Daisy Mui Hung , Anwar Aizza , Gwee Sai Ling , Ijaz Muhammad Fazal
Published: January 2023

Penang Youth Development Corporation took the “Penang Young Digital Talent Program” initiative to bridge the gap between Malaysian youth’s current digital skills and emerging technologies market demands. The program comprises different online courses such as web design, digital marketing, etc. The objective of this study is to understand the level of participants’ digital competency and, secondly, investigate the impact of participants’ digital competency on their perceived employability and examine the mediating role of course quality. This study employed a cross-section design method, and data were collected using purposive sampling. The participants (Nn= 385) of this program range from 18 to 22 years old, either born in Penang or have resided in Penang for a minimum of 3 years. The data were analyzed using Smart PLS 3.0. Post-online course findings show that digital content creation, information and data literacy, and problem-solving have a significant and positive relationship with perceived employability. Moreover, course quality significantly mediates the impact of communication and collaboration, digital safety and information and data literacy on the perceived employability of Malaysian youth. The findings of this research have implications for policymakers responsible for education, emphasizing youth’s acquisition of digital skills to help them succeed in the current workplace.
Drivers and Outcomes of Digital Transformation: The Case of Public Sector Services
Authors: Kitsios Fotis , Kamariotou Maria , Mavromatis Archelaos
Published: January 2023

Governments are altering how they operate to enhance the provision of public services, be more successful and efficient in their plans, and accomplish goals such as greater transparency, interoperability, and citizen pleasure. There are, however, limited studies about how public sector managers are currently identifying digital transformation in their own day-to-day practices, how they are implementing digital transformation projects, and what their expected results are, aside from the reports provided by consulting firms. The aim of this article is to present a case study in order to gain an understanding of the current expectations that public managers have regarding the implementation of digital transformation projects, as well as the outcomes that they anticipate these projects will produce. A qualitative analysis was conducted based on experts who were involved in digital transformation projects with a thorough understanding of government decisions and in-depth knowledge of execution procedures. Based on the results derived from interviews, this paper aims to support managers in examining the barriers of digital transformation in the public sector in order to improve this process.
Forecasting the Capacity of Open-Ended Pipe Piles Using Machine Learning
Authors: Ozturk Baturalp , Kodsy Antonio , Iskander Magued
Published: January 2023

Pile design is an essential component of geotechnical engineering practice, and pipe piles, in particular, are increasingly being used for the support of a variety of infrastructure projects. These piles are being used with dimensions that exceed those used in the development of the most widely used design approaches. At the same time, the growth in pile dimensions calls for the evolution of the state-of-the-art at a similar pace. The objective of this study is to provide an improved prediction of pile capacity. A database of 112 load tests on pipe piles ranging in diameter from 10 to 100 in. (0.25–2.5 m) and in length from 10 to 320 ft. (3–98 m) was employed in this study. First, design capacities were computed using four popular design methods and compared to capacities interpreted from a load test. For the employed dataset, the Revised Lambda method was found to best predict capacities of pipe piles obtained from a load test, among the four examined methods, and was thus employed as a reference standard for assessing the performance of ML methods. Next, eight ML regression models were trained to compute the capacity of pipe piles. Several trained ML models predicted capacities for the testing data set on par with the Revised Lambda method, and three were selected for further investigation. A variety of pile dimensions and soil properties were examined as input properties for ML and the trained models performed surprisingly well with only the pile dimensions used as input. In addition, ML models exhibited satisfactory diameter and length effects, which have been areas of concern for some traditional design approaches. The work thus demonstrates the feasibility of employing machine learning (ML) for determining the capacity of pipe piles. A web application was also developed as a tool for forecasting the capacity of pipe piles using ML.
Thermodynamic Analysis of the Low-Grade Heat Sources for the Improvement in Efficiency of Oxy–Fuel Combustion Power Cycles
Authors: Komarov Ivan , Kindra Vladimir , Pisarev Dmitry , Kovalev Dmitriy , Lvov Dmitriy
Published: January 2023

Today, most of the electrical energy in the world is generated by fossil fuel incineration. This causes significant emissions of harmful substances into the atmosphere. The noted problem can be solved by switching to power plants with zero emissions, operating in semi-closed cycles, and producing electricity through oxygen combustion of fuel. A significant drawback of most of the known oxygen–fuel cycles is the lack of useful utilization of various sources of low-grade heat, which is especially typical for power plants operating on gasified coal fuel; as a result of the gasification process, a significant amount of excess heat is released into the atmosphere. This paper presents the results of the development and study of oxygen–fuel cycle thermal schemes of increased efficiency with coal gasification. It was determined that the modernization of the scheme using the carbon dioxide Rankine cycle for the utilization of low-grade heat makes it possible to achieve an increase in the net electrical efficiency equal to 1.2%.
The Efficacy of Strength Exercises for Reducing the Symptoms of Menopause: A Systematic Review
Authors: Capel-Alcaraz Ana María , García-López Héctor , Castro-Sánchez Adelaida María , Fernández-Sánchez Manuel , Lara-Palomo Inmaculada Carmen
Published: January 2023

Background: The aim of this systematic review was to determine whether strength exercises improve the symptoms of menopause and to provide an update on the most recent scientific evidence on the type and regimen of exercise that help reduce the symptoms. Methods: An electronic search of scientific databases was performed from 2015 to 2022. Randomized clinical trials that analyzed the effects of strength exercises versus other types of interventions, considering all the outcome measures of interest, were included in this review. Results: We found 5964 potential articles. After applying the selection criteria, we selected 12 of the articles. The studies compared strength exercises versus other therapies or compared strength exercises versus no intervention in one of the groups. The results showed improvements in the strength of the legs and pelvic floor, physical activity, bone density, metabolic and hormonal changes, heart rate and blood pressure and a change in hot flashes. Conclusions: There is evidence that strength exercises can be beneficial for improving strength, physical activity, bone density and hormonal and metabolic levels. In terms of the appropriate type of strength training, the evidence is still unclear given that the same benefits are achieved by various types of exercises.
Caregivers of Neuromuscular Patients Living with Tracheostomy during COVID-19 Pandemic: Their Experience
Authors: Pierucci Paola , Volpato Eleonora , Grosso Francesca , De Candia Maria , Casparrini Massimo , Compalati Elena , Pagnini Francesco , Banfi Paolo , Carpagnano Giovanna
Published: January 2023

Background: During a pandemic, tracheostomy management in neuromuscular disease (NMD) patients can be complex. Methods: Using a multicentre, multiple case study approach, we sought perspectives through semi-structured interviews via hybrid quali-quantitative analysis. The qualitative analysis involved a semi-structured interview and the quantitative analysis the completion of a battery of questionnaires. Aim: To investigate the caregivers’ experiences, burden and beliefs regarding tracheostomy during the Italian COVID-19 pandemic. The following instruments were administered: Connor and Davidson Resilience Scale (CD-RISC-25); Acceptance and Action Questionnaire-II (AAQ-II); State-Trait Anxiety Inventory (STAI); Langer Mindfulness Scale (LMS); Zarit Burden Interview (ZBI). Results: Fifty-three caregivers (62.3% female, mean age 52.2 (SD = 18.2)) participated in the study. The more resilient the carers, the more they were psychologically flexible (r = 0.380, p = 0.014) and able to cope adaptively with the emergency (r = 0.378, p < 0.006). Similarly, perceived control was higher the more resilient they were (r = 0.897, p < 0.001). The main emotions emerging were isolation and loneliness (15; 34.88%). The perception of tracheostomy meant that it could be seen as a lifesaver or as a condemnation. Similarly, the relationship with health professionals moves from satisfaction to a feeling of abandonment over the course of the pandemic. Conclusions: These findings offer a unique opportunity to understand the point of view of caregivers of NMD patients living with tracheotomy during the COVID-19 pandemic, when going to the hospital may have been hampered.
On the Influence of Fatigue Damage in Short-Fibre Reinforced Thermoplastic PBT GF30 on Its Residual Strength under High Strain Rates: An Approach towards Simulative Prediction
Authors: Witzgall Christian , Steck Patrick , Wartzack Sandro
Published: January 2023

Only by using accurate material data can precise simulation results be achieved. This principle also and especially applies in the field of crash simulation. However, in the simulation of short-fibre reinforced thermoplastics, material parameters are usually used that originate from the material testing of as-new samples. In order to get closer to the condition on the roads, where not only new vehicles are driving, the influence of service loads on the crashworthiness has to be investigated. This paper reports on studies of PBT GF30, a polybutylene terephthalate reinforced with 30% glass fibres, in which fatigue damage was induced in the material by cyclic loading. The residual strength was then determined in a high-speed experiment and compared with the strength of virgin samples. In order to enable the usability of the findings in the simulation, a modified failure criterion was implemented that takes the previous fatigue damage into account. The prediction quality of the simulation model was compared with the experimental findings and it can be concluded that there is good agreement.
Single-Component Physical Hydrogels of Dendritic Molecules
Authors: Apartsin Evgeny , Caminade Anne-Marie
Published: January 2023

Hydrogels are hydrophilic, three-dimensional networks able to imprison large amounts of water and are largely used in pharmaceutical formulations. Hydrogels are frequently obtained from hydrophilic polymers, either natural, biohybrid, or synthetic. Owing to their peculiar structure, dendrimers can be considered prospective building blocks for hydrogel networks. This review gathers the use of different types of amphiphilic dendritic structures able to generate physical hydrogels alone. Such dendritic structures comprise dendrimers, Janus dendrimers, and dendrons. The first part concerns different types of positively charged phosphorus dendrimers used to generate hydrogels, which are also suitable to form fibers, and for encapsulating diverse substances, or forming complexes with genetic materials for their slow delivery. The second part concerns PAMAM dendrimers functionalized with collagen mimetics. The third part concerns amphiphilic Janus dendrimers, whereas the fourth part displays different types of amphiphilic dendrons and their use, in particular in the fields of materials and drug delivery.
New Neutron Imaging Facility NIFFLER at Very Low Power Reactor VR-1
Authors: Matouskova Jana , Schillinger Burkhard , Sklenka Lubomir
Published: January 2023

The paper describes the construction of the neutron imaging facility at the very low-power research reactor VR-1. The training reactor VR-1 is operated by the Czech Technical University in Prague, Czech Republic. It is mainly used for the education of students in the field of nuclear engineering as well as for the training of professionals. Neutron imaging is the new field of VR-1 reactor utilisation currently under development. Extremely low reactor power at the level of 100 W brought many challenges that were necessary to overcome to build and commission a sustainable neutron radiography facility. The paper describes the reactor’s neutron flux verification and the basic concept and design of the neutron imaging instrumentation. The first experimental results were mainly dedicated to testing the detection system for different radial beam port configurations, different L/D ratios, and different exposure times. Preliminary results of neutron radiography and tomography measurements at VR-1 clearly showed the potential of using neutron imaging in low-power reactors such as the VR-1 reactor.
A Circular-Arc-Type Magnetic Coupler with Strong Misalignment Tolerance for AUV Wireless Charging System
Authors: Xia Tao , Li Hang , Yu Haitao , Zhang Yangfei , Hu Pengfei
Published: January 2023

The wireless charging system (WCS) is widely employed to solve the problem of underwater charging of autonomous underwater vehicles (AUVs). However, the AUV is prone to misalignment caused by the tidal currents, which directly leads to fluctuations in transmission efficiency and output power. For this reason, a circular-arc-type (CA-type) magnetic coupler with strong misalignment tolerance was proposed in this article. Compared with the ring-type magnetic coupler, the proposed magnetic coupler had better magnetic field convergence and lower weight. Further, the effect of dimensional parameters on the CA-type magnetic coupler performance was analyzed by ANSYS Maxwell, with which the parameters of the magnetic coupler were optimized, and its coupling coefficient could finally reach 0.671. To analyze the influence of misalignment on the CA-type magnetic coupler, EE-type and UI-type magnetic cores are compared. Within the same range of rotation misalignment [−10°, 10°] and axial misalignment [−30, 30 mm], the CA-type magnetic core has stronger misalignment adaptability, and it can achieve a stable output power of 575 W and DC-DC efficiency of 92.51% when rotational misalignment occurs. A WCS experimental prototype is built based on one of the magnetic couplers and its experimental results verify the correctness of the theoretical analysis and simulation results.
Reconstruction of the Instantaneous Images Distorted by Surface Waves via Helmholtz–Hodge Decomposition
Authors: Jian Bijian , Ma Chunbo , Sun Yixiao , Zhu Dejian , Tian Xu , Ao Jun
Published: January 2023

Imaging through water waves will cause complex geometric distortions and motion blur, which seriously affect the correct identification of an airborne scene. The current methods main rely on high-resolution video streams or a template image, which limits their applicability in real-time observation scenarios. In this paper, a novel recovery method for the instantaneous images distorted by surface waves is proposed. The method first actively projects an adaptive and adjustable structured light pattern onto the water surface for which random fluctuation will cause the image to degrade. Then, the displacement field of the feature points in the structured light image is used to estimate the motion vector field of the corresponding sampling points in the scene image. Finally, from the perspective of fluid mechanics, the distortion-free scene image is reconstructed based on the Helmholtz-Hodge Decomposition (HHD) theory. Experimental results show that our method not only effectively reduces the distortion to the image, but also significantly outperforms state-of-the-art methods in terms of computational efficiency. Moreover, we tested the real-scene sequences of a certain length to verify the stability of the algorithm.
Predictive Modeling of Eastern Little Tuna (Euthynnus affinis) Catches in the Makassar Strait Using the Generalized Additive Model
Authors: Puspita Ajeng R. , Syamsuddin Mega L. , Subiyanto  , Syamsudin Fadli , Purba Noir P.
Published: January 2023

The Makassar Strait (MS) is characterized by water mass from the Pacific Ocean and is one of the ITF (Indonesia Throughflow) branches. It carries warm water masses from the Pacific Ocean to the Indian Ocean. This research aims to analyze the relationship between CPUE of Eastern Little Tuna (Euthynnus affinis) and oceanographic variables, likewise predict the fishing area using the Generalized Additive Model (GAM). The research method used is spatial and temporal analysis. The data was used from 2015 to 2020. The data processed were sea surface temperature, chlorophyll-a, salinity, currents, sea level as predictor variables, and Eastern Little Tuna production as a response. Eastern Little Tuna catch data were normalized into Catch per Unit Effort, while the oceanographic data were extracted using ArcGIS. Based on the results of the GAM model, it was found that the model with five variables is the most suitable predictive model, with 16.4% CDE. Salinity is the most influential parameter on the catch of Eastern Little Tuna with a significance value of <2.00 × 10−16 ***. The optimum value for SST is 30–31 °C, chlorophyll-a is 1–2 mg/m3, salinity is 29–30 ppt, current velocity is 0.3–0.5 m/s and sea level is between 0.6–0.7 m. Based on the GAM prediction results, a high CPUE value will be obtained in the southwest monsoon (March to May). Fishing activity carried out in the best season will implement the adoption of harvest control measures.
Artificial Reefs Research
Authors: Na Won-Bae
Published: January 2023

Human intervention is required to preserve wild animals due to human-induced problems such as climate change and altered habitats [...]
A Comparative Centrifuge Test Study on the Influence of Overlying Seawater on Seismic Response Spectrum
Authors: Liu Juan , Wang Ting , Lan Jingyan , Song Xijun
Published: January 2023

In this study, dynamic centrifugal model tests for two homogeneous saturated soft clay sites are designed to analyze the influence of overlying sea water on ground motion. We obtain the response spectrum value and amplification coefficient from the acceleration sensor records. Through comparative analysis, we conclude that with the increase in input peak ground motion, the acceleration response spectrum value at the same depth gradually increases. When the input peak value is small, there is no significant difference between the response spectra with and without water; when the input peak value is large, there is no significant difference in the high-frequency part of the response spectrum value. In the middle- and low-frequency part, the response spectrum value with water is obviously smaller than that without water. The amplitude of the response spectrum of the water-free model gradually moves in the long-period direction, but the water model tends to the short-period direction. In the long-period part, the amplification coefficient of the water model is obviously smaller than that of the water free model.
Maritime Autonomous Vessels
Authors: Xu Haitong , Moreira Lúcia , Guedes Soares C.
Published: January 2023

Recent years have seen the rapid development of autonomous ships [...]
Soil Microbial Community Responses to Different Management Strategies in Almond Crop
Authors: Camacho-Sanchez Miguel , Herencia Juan F. , Arroyo Francisco T. , Capote Nieves
Published: January 2023

A comparative study of organic and conventional farming systems was conducted in almond orchards to determine the effect of management practices on their fungal and bacterial communities. Soils from two orchards under organic (OM) and conventional (CM), and nearby nonmanaged (NM) soil were analyzed and compared. Several biochemical and biological parameters were measured (soil pH, electrical conductivity, total nitrogen, organic material, total phosphorous, total DNA, and fungal and bacterial DNA copies). Massive parallel sequencing of regions from fungal ITS rRNA and bacterial 16 S genes was carried out to characterize their diversity in the soil. We report a larger abundance of bacteria and fungi in soils under OM, with a more balanced fungi:bacteria ratio, compared to bacteria-skewed proportions under CM and NM. The fungal phylum Ascomycota corresponded to around the 75% relative abundance in the soil, whereas for bacteria, the phyla Proteobacteria, Acidobacteriota and Bacteroidota integrated around 50% of their diversity. Alpha diversity was similar across practices, but beta diversity was highly clustered by soil management. Linear discriminant analysis effect size (LEfSE) identified bacterial and fungal taxa associated with each type of soil management. Analyses of fungal functional guilds revealed 3–4 times larger abundance of pathogenic fungi under CM compared to OM and NM treatments. Among them, the genus Cylindrocarpon was more abundant under CM, and Fusarium under OM.
Computer-Aided Design and Computer-Aided Modeling (CAD/CAM) for Guiding Dental Implant Surgery: Personal Reflection Based on 10 Years of Real-Life Experience
Authors: Scolozzi Paolo , Michelini Francesco , Crottaz Claude , Perez Alexandre
Published: January 2023

Traditional dental implant surgery has been challenged by the phenomenal progression in computer-assisted surgery (CAS) that we have been witnessing in recent years. Among the computer-aided technologies, computer-aided design and computer-aided manufacturing (CAD/CAM) techniques represent by far the most attractive and accepted alternatives over their dynamic counterpart, navigational assistance. Based on many years of experience, we have determined that CAD/CAM technology for guiding dental implant surgery is valuable for rehabilitation of the anterior maxillary region and the management of complete or severe partial edentulism. The technology also guarantees the 3D parallelism of implants. The purpose of the present report is to describe indications for use of CAD/CAM dental implant guided surgery. We analyzed the clinical and radiological data of thirteen consecutive edentulous patients treated using CAD/CAM techniques. All of the patients had stable cosmetic results with a high rate of patient satisfaction at the final follow-up examination. No intra- and/or postoperative complications were encountered during any of the steps of the procedure. The application of CAD/CAM techniques produced successful outcomes in the patients presented in this series.
Insights into Personalised Medicine in Bronchiectasis
Authors: Fraser Clementine S. , José Ricardo J.
Published: January 2023

Bronchiectasis is a heterogenous disease with multiple aetiologies resulting in inflammation and dilatation of the airways with associated mucus production and chronic respiratory infection. The condition is being recognised ever more frequently as the availability of computed tomography increases. It is associated with significant morbidity and healthcare-related costs. With new understanding of the disease process, varying endotypes, identification of underlying causes and treatable traits, the management of bronchiectasis can be increasingly personalised.
Investigating the Impacts of Urban Built Environment on Travel Energy Consumption: A Case Study of Ningbo, China
Authors: Wu Wei , Xue Binxia , Song Yan , Gong Xujie , Ma Tao
Published: January 2023

The built environment of cities has increasingly affected the travel mode of residents and led to changes in energy consumption, which is crucial to maintaining urban sustainability. Ningbo is a typical representative of urbanization on the east coast of China, and its energy consumption is in a period of rapid growth. Therefore, using the survey data of 22,112 traffic trip samples from nine streets in Ningbo, this paper establishes a regression analysis model, systematically analyzes the relationship between the built environment and domestic energy consumption from multiple dimensions, and reveals the impact mechanism of the built environment on domestic energy consumption. We find that (1) social and economic conditions are the main factors affecting traffic energy consumption. (2) The population density has a significant negative correlation effect on the energy consumption of transportation trips. When the population density increases by 1%, the energy consumption of total transportation trips, commuting trips, high-energy-consumption trips, and low-energy-consumption trips decreases by 0.094%, 0.115%, 0.273%, and 0.124%, respectively. (3) When the degree of mixed use of land increases by one percentage point, the energy consumption of total transportation trips, commuting trips, high-energy-consumption trips, and low-energy-consumption trips decreases by 0.415%, 0.421%, 2.574%, and 1.197%, respectively. (4) The density of road intersections has a significant negative correlation effect on the energy consumption of traffic trips. (5) The impact of the built environment on the energy consumption of transportation trips is greater than that of residential buildings.
Morphological Evaluation of the Splenic Artery, Its Anatomical Variations and Irrigation Territory
Authors: Covantsev Serghei , Alieva Fariza , Mulaeva Karina , Mazuruc Natalia , Belic Olga
Published: January 2023

Background: Precise knowledge of the topographic features of the splenic artery and its branches in the hilum region is of practical interest due to the various interventions on the vessels of the spleen. Materials and methods: The anatomy of the spleen was studied by means of macroscopic dissection on 330 organ complexes, which were carefully documented and analyzed statistically. Results: The analysis of the splenic artery trajectory led to identification of four types: straight (43.03%), sinusoidal (27.58%), serpentine (20.91%) and alternating (8.48%). To assess the relation between the trajectory of the splenic artery and its branches we performed a chi square test. Sinuous or serpentine trajectory was associated with the presence of long splenic artery branches (dorsal pancreatic artery or the great pancreatic artery), X2 (2, N = 330) = 12.85, p = 0.001. The artery was located suprapancreatic in 70.30% of cases, anteropancreatic in 4.55%, the vessel had an intrapancreatic course in 14.85% and in 10.00% of cases the artery was located retropancreatic. The presence of inferior polar arteries was associated with a longer pancreas (Spearman’s correlation; r = 0.37; p = 0.037). In a multiple regression analysis, inferior polar arteries predicted the length of the pancreas although only a small number of cases could be explained by this model (R2 = 0.127, Adjusted R2 = 0.098; Betta = 0.357; t(330) = 2.091; p = 0.045). There were 30 (9.09%) cases of accessory spleens. Conclusions: The arterial supply of the spleen is highly variable in its trajectory, terminal branches, and relation to other organs. The splenic artery tends to be sinuous or serpentine in zones when a large artery branches off (e.g., the dorsal pancreatic or greater pancreatic artery). Multiple short branches tend to stabilize the trajectory of the splenic artery. Inferior polar arteries and accessory spleens contribute to the length of the pancreas, most likely due to increased vascular supply to the tail of the gland.
Software-Based Assessment of Well-Aerated Lung at CT for Quantification of Predicted Pulmonary Function in Resected NSCLC
Authors: Colombi Davide , Risoli Camilla , Delfanti Rocco , Chiesa Sara , Morelli Nicola , Petrini Marcello , Capelli Patrizio , Franco Cosimo , Michieletti Emanuele
Published: January 2023

Background: To test the agreement between postoperative pulmonary function tests 12 months after surgery (mpo-PFTs) for non-small cell lung cancer (NSCLC) and predicted lung function based on the quantification of well-aerated lung (WAL) at staging CT (sCT). Methods: We included patients with NSCLC who underwent lobectomy or segmentectomy without a history of thoracic radiotherapy or chemotherapy treatment with the availability of PFTs at 12 months follow-up. Postoperative predictive (ppo) lung function was calculated using the resected lobe WAL (the lung volume between −950 and −750 HU) at sCT. The Spearman correlation coefficient (rho) and intraclass correlation coefficient (ICC) were used to the test the agreement between WAL ppo-PFTs and mpo-PFTs. Results: the study included 40 patients (68 years-old, IQR 62–74 years-old; 26/40, 65% males). The WAL ppo-forced expiratory volume in 1 s (FEV1) and the ppo-diffusing capacity of the lung for carbon monoxide (%DLCO) were significantly correlated with corresponding mpo-PFTs (rho = 0.842 and 0.717 respectively; p < 0.001). The agreement with the corresponding mpo-PFTs of WAL ppo-FEV1 was excellent (ICC 0.904), while it was good (ICC 0.770) for WAL ppo-%DLCO. Conclusions: WAL ppo-FEV1 and WAL ppo-%DLCO at sCT showed, respectively, excellent and good agreement with corresponding mpo-PFTs measured 12 months after surgery for NSCLC. WAL is an easy parameter obtained by staging CT that can be used to estimate post-resection lung function for patients with borderline pulmonary function undergoing lung surgery.
Analysis of G-Quadruplex-Forming Sequences in Drought Stress-Responsive Genes, and Synthesis Genes of Phenolic Compounds in Arabidopsis thaliana
Authors: Pečinka Petr , Bohálová Natália , Volná Adriana , Kundrátová Kristýna , Brázda Václav , Bartas Martin
Published: January 2023

Sequences of nucleic acids with the potential to form four-stranded G-quadruplex structures are intensively studied mainly in the context of human diseases, pathogens, or extremophile organisms; nonetheless, the knowledge about their occurrence and putative role in plants is still limited. This work is focused on G-quadruplex-forming sites in two gene sets of interest: drought stress-responsive genes, and genes related to the production/biosynthesis of phenolic compounds in the model plant organism Arabidopsis thaliana. In addition, 20 housekeeping genes were analyzed as well, where the constitutive gene expression was expected (with no need for precise regulation depending on internal or external factors). The results have shown that none of the tested gene sets differed significantly in the content of G-quadruplex-forming sites, however, the highest frequency of G-quadruplex-forming sites was found in the 5′-UTR regions of phenolic compounds’ biosynthesis genes, which indicates the possibility of their regulation at the mRNA level. In addition, mainly within the introns and 1000 bp flanks downstream gene regions, G-quadruplex-forming sites were highly underrepresented. Finally, cluster analysis allowed us to observe similarities between particular genes in terms of their PQS characteristics. We believe that the original approach used in this study may become useful for further and more comprehensive bioinformatic studies in the field of G-quadruplex genomics.
Determination of the Ni(II) Ions Sorption Mechanism on Dowex PSR2 and Dowex PSR3 Ion Exchangers Based on Spectroscopic Studies
Authors: Bąk Justyna , Sofińska-Chmiel Weronika , Gajewska Maria , Malinowska Paulina , Kołodyńska Dorota
Published: January 2023

This paper estimates the suitability of the strongly basic anion exchangers, Dowex PSR2 and Dowex PSR3, as sorbents of nickel ions in aqueous solutions. These actions are aimed at searching for new solutions due to the growing discharge of nickel into wastewaters, primarily due to its addition to steel. The nickel sorption experiments were conducted under static conditions and resulted in the optimization of pH, phase contact time, initial solution concentration, and temperature. The next step was to calculate the kinetic, isothermal, and thermodynamic parameters. Moreover, the ion exchangers were characterized by means of Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and CHN elemental analysis. It was found that the sorption process was most effective at pH 6 after 240 min and at the temperature of 293 K. The values of the thermodynamic parameters revealed that the adsorption was exothermic and spontaneous. The physicochemical analyses combined with the experimental research enabled determination of the sorption mechanism of Ni(II) ions.
Crystallization Kinetics and Structure Evolution during Annealing of Ni-Co-Mn-In Powders Obtained by Mechanical Alloying
Authors: Matyja Edyta , Prusik Krystian , Zubko Maciej , Świec Paweł , Dercz Grzegorz , Loskot Jan
Published: January 2023

The crystallization kinetics and structure evolution during annealing of the Ni45.5Co4.5Mn36.6In13.4 (at. %) powders produced by mechanical alloying (MA) was investigated. After 70 h and 100 h of MA, the powder consisted of a mixture of amorphous and nanocrystalline body-centered cubic (bcc) phases. We observed the relaxation in the as-received powder. The relaxation temperature (Tre) increases logarithmically with the annealing time. Annealing above 440 °C results in (1) ordering of L21, (2) dissolution of the residual Ni and Mn, (3) tetragonal MnNi phase formation and (4) γ phases precipitation. The activation energies of the B2 → L21 and Mn (α-Mn) → MnNi (P4/mmm) transformations were calculated.
Brillouin Scattering Study of Electro-Optic KTa1−xNbxO3 Crystals
Authors: Rahaman Md. Mijanur , Kojima Seiji
Published: January 2023

The functionality enhancement of ferroelectrics by local polar clusters called polar nanoregions (PNRs) is one of the current interests in materials science. KTa1−xNbxO3 (KTN) with perovskite structure is a well-known electro-optic crystal with a large Kerr effect. The existence of PNRs in relaxor-like ferroelectric Nb-rich KTN with homovalent B-site cations is controversial. This paper reviews recent progress in understanding precursor dynamics in Nb-rich KTN crystals studied using Brillouin scattering. The intense central peak (CP) and significant softening of sound velocity are observed above the Curie temperature (TC) due to the polarization fluctuations in PNRs. The effects of Li-doping, defects, and electric fields on the growth and/or creation of PNRs are found using changes in acoustic properties. The electric-field-induced TC, which is shifted to higher values with increases in applied voltage, including critical endpoint (CEP) and field gradient by trapped electrons, are discussed as well. This new knowledge may give new insight into advanced functionality in perovskite ferroelectrics.
Corrosion Behavior of Cobalt Oxide and Lithium Carbonate on Mullite–Cordierite Saggar Used for Lithium Battery Cathode Material Sintering
Authors: Sun Zhenhua , Li Shaopeng , Li Huiquan , Liu Mingkun , Li Zhanbing , Liu Xianjie , Liu Mingyong , Liu Qiyun , Huang Zhaohui
Published: January 2023

Mullite–cordierite ceramic saggar is a necessary consumable material used in the synthesis process of LiCoO2 that is easily eroded during application. In our study, we systematically investigated the characteristics and surface corrosion behavior of waste saggar samples. We divided the cross sections of waste saggar into the attached layer, hardened layer, permeability layer, and matrix layer. Then, we examined the high-temperature solid-state reactions between saggar powder and lithium carbonate or cobalt oxide to identify erosion reactants correlating with an increase in the number of recycled saggars. The results of time-of-flight secondary ion mass spectrometric analysis (TOF-SIMS) prove that the maximum erosion penetration of lithium can reach 2 mm. However, our morphology and elemental distribution analysis results show that the erosion penetration of cobalt was only 200 μm. When enough lithium carbonate reacted, lithium aluminate and lithium silicate were the main phases. Our X-ray computed tomography (X-ray CT) analysis results show that the change in phase volume before and after the reaction, including the generation of oxygen and carbon dioxide gas, led to the internal crack expansion of the material–saggar interface. Our results can contribute to improving saggar and upgrading waste saggar utilization technology.
Microstructure and Mechanical Properties of Hypereutectic Al-High Si Alloys up to 70 wt.% Si-Content Produced from Pre-Alloyed and Blended Powder via Laser Powder Bed Fusion
Authors: Risse Jan Henning , Trempa Matthias , Huber Florian , Höppel Heinz Werner , Bartels Dominic , Schmidt Michael , Reimann Christian , Friedrich Jochen
Published: January 2023

Hypereutectic Al-high Si alloys are of immense interest for applications in the automotive, space or electronic industries, due their low weight, low thermal expansion, and excellent mechanical and tribological properties. Additionally, their production by laser powder bed fusion (LPBF) technology provides high flexibility in geometrical design and alloy composition. Since, most of the alloy properties could be improved by increasing the Si content, there is much interest in discovering the maximum that could be realized in LBPF Al-high Si alloys, without the appearance of any material failure. For this reason, in this work the production of Al-high Si alloys with extremely high silicon content of up to 70 wt.% was fundamentally investigated with respect to microstructure and mechanical properties. Highly dense (99.3%) and crack-free AlSi50 samples (5 × 5 × 5 mm3), with excellent hardness (225 HV5) and compressive strength (742 MPa), were successfully produced. Further, for the first time, AlSi70 LBPF samples of high density (98.8%) without cracks were demonstrated, using moderate scanning velocities. Simultaneously, the hardness and the compressive strength in the AlSi70 alloys were significantly improved to 350 HV5 and 935 MPa, as a result of the formation of a continuous Si network in the microstructure of the alloy. With respect to the powder source, it was found that the application of powder blends resulted in similar alloy properties as if pre-alloyed powders were used, enabling higher flexibility in prospective application-oriented alloy development.
Synthesis and Catalytic Study of NiAg Bimetallic Core–Shell Nanoparticles
Authors: Wojtaszek Konrad , Cebula Filip , Rutkowski Bogdan , Wytrwal Magdalena , Csapó Edit , Wojnicki Marek
Published: January 2023

This publication presents the synthesis of core–shell nanoparticles, where the core was Ni, and the shell was a Ag–Ni nano alloy. The synthesis was based on the reduction of Ni and Ag ions with sodium borohydride in the presence of trisodium citrate as a stabilizer. In order to determine the phase composition of the obtained nanoparticles, an XRD study was performed, and in order to identify the oxidation states of the nanoparticle components, an XPS spectroscopic study was performed. The composition and shape of the particles were determined using the HR-TEM EDS test. The obtained nanoparticles had a size of 11 nm. The research on catalytic properties was carried out in the model methylene blue reduction system. The investigation of the catalytic activity of colloids was carried out with the use of UV–Vis spectrophotometry. The Ag–Ni alloy was about ten times more active than were pure silver nanoparticles of a similar size.
Thermoelectric Response Enhanced by Surface/Edge States in Physical Nanogaps
Authors: García-Suárez Víctor Manuel
Published: January 2023

Current solid-state thermoelectric converters have poor performance, which typically renders them useless for practical applications. This problem is evidenced by the small figures of merit of typical thermoelectric materials, which tend to be much smaller than 1. Increasing this parameter is then key for the development of functional devices in technologically viable applications that can work optimally. We propose here a feasible and effective design of new thermoelectric systems based on physical gaps in nanoscale junctions. We show that, depending on the type of features, i.e., the character of surface/edge states, on both sides of the gap, it is possible to achieve high figures of merit. In particular, we show that, for configurations that have localized states at the surfaces/edges, which translate into sharp resonances in the transmission, it is possible to achieve large Seebeck coefficients and figures of merit by carefully tuning their energy and their coupling to other states. We calculate the thermoelectric coefficients as a function of different parameters and find non-obvious behaviors, such as the existence of a certain coupling between the localized and bulk states for which these quantities have a maximum. The highest Seebeck coefficients and figures of merit are achieved for symmetric junctions, which have the same coupling between the localized state and the bulk states on both sides of the gap. The features and trends of the thermoelectric properties and their changes with various parameters that we find here can be applied not only to systems with nanogaps but also to many other nanoscale junctions, such as those that have surface states or states localized near the contacts between the nanoscale object and the electrodes. The model presented here can, therefore, be used to characterize and predict the thermoelectric properties of many different nanoscale junctions and can also serve as a guide for studying other systems. These results pave the way for the design and fabrication of stable next-generation thermoelectric devices with robust features and improved performance.
Effect of Heat Treatment on the Dry Sliding Wear Behavior of the Mg-3Zn-0.4Ca Alloy for Biodegradable Implants
Authors: Pulido-González Nuria , García-Rodríguez Sonia , Torres Belén , Rams Joaquin
Published: January 2023

The wear behavior of the Mg-3wt.% Zn-0.4wt.% Ca (ZX30) alloy was tested using a pin-on-disc configuration with AZ31 alloy discs as counterparts under dry sliding conditions. The ZX30 alloy was tested in different states: as-cast, solution-treated, peak-aged, and over-aged. Wear rates and friction coefficients were measured at different loads and sliding speeds. Abrasion and oxidation were the main wear mechanisms found in all the conditions tested. Moreover, aluminum oxides were detected on the worn surfaces, which indicates the presence of an adhesive wear mechanism. The wear behavior of the studied ZX30 alloy showed a greater tendency towards oxidative wear than other Mg alloys, and the microstructure observed strongly affected the wear behavior.
Investigation on the Performance of Coated Carbide Tool during Dry Turning of AISI 4340 Alloy Steel
Authors: Wagri Naresh Kumar , Jain Neelesh Kumar , Petare Anand , Das Sudhansu Ranjan , Tharwan Mohammed Y. , Alansari Abdulkarim , Alqahtani Bader , Fattouh Majed , Elsheikh Ammar
Published: January 2023

The machinability of materials is highly affected by their hardness, and it affects power consumption, cutting tool life as well as surface quality while machining the component. This work deals with machining of annealed AISI 4340 alloy steel using a coated carbide tool under a dry environment. The microhardness of annealed and non-annealed workpieces was compared and a significant reduction was found in the microhardness of annealed samples. Microstructure examination of the annealed sample revealed the formation of coarse pearlite which indicated a reduction of hardness and improved ductility. A commercially CVD multilayer (TiN/TiCN/Al2O3/ZrCN) coated cemented carbide cutting tool was employed for turning quenched and tempered structural AISI 4340 alloy steel by varying machining speed, rate of feed, and depth of cut to evaluate the surface quality, machining forces, flank wear, and chip morphology. According to the findings of experiments, the feed rate possesses a high impact on surface finish, followed by cutting speed. The prominent shape of the serrated saw tooth chip was noticed at a higher cutting speed. Machined surface finish and cutting forces during turning is a function of the wear profile of the coated carbide insert. This study proves that annealing is a low-cost and economical process to enhance the machinability of alloy steel.