bluuebunny/crossref_metadata_2025 huggingface dataset:
ВИКОРИСТАННЯ АНАЛІТИЧНИХ І БІОАНАЛІТИЧНИХ МЕТОДИК ДЛЯ ВИЯВЛЕННЯ ТА КІЛЬКІСНОГО ВИЗНАЧЕННЯ ЗОПІКЛОНУ, ЗОЛПІДЕМУ, ЗАЛЕПЛОНУ В РІЗНОМАНІТНИХ ОБ’ЄКТАХ
Authors: Коробчук В. М. , Загричук Г. Я. , Михалків М. М. , Яцюк В. М. , Івануса І. Б.
Published: August 2024

Вступ. Інсомнія, або безсоння, є поширеною проблемою в усьому світі й має значний вплив на здоров’я і якість життя людей. Зопіклон, золпідем і залеплон широко та ефективно використовують у медичній практиці як за кордоном, так й в Україні для лікування безсоння. Крім того, лікарські засоби цієї групи можна призначати при лікуванні шизофренії, деменції. Відповідно до фармакопейних монографій різних країн світу, для ідентифікації зопіклону, золпідему та залеплону використовують методи ІЧ-, УФ-спект­рофотометрії, інколи рідинну хроматографію, з метою кількісного визначення зопіклону і золпідему застосовують метод неводного кислотно-основного титрування з потенціометричним фіксуванням точки еквівалентності, залеплону – метод рідинної хроматографії. Огляд наукових джерел показав, що для аналізу субстанцій та визначення активних фармацевтичних інгредієнтів у лікарських засобах часто використовують методи рідинної хроматографії, а саме високоефективну рідинну хроматографію, ­ультра високоефективну рідинну хроматографію, рідинну хроматографію з мас-спектрометрією, рідинну хроматографію з тандемною мас-спектрометрією. Є декілька публікацій, присвячених кількісному визначенню зопіклону методом екстракційно-фотометричного аналізу з використанням метилового оранжевого як реагенту і хлороформу як екстрагенту. Серед біологічних об’єктів найчастіше аналізують зопіклон, залеплон і золпідем та їх метаболіти у крові й сечі, є також повідомлення про використання волосся як об’єкта токсикологічного аналізу. Для очистки об’єктів від домішок застосовують метод твердофазної екстракції, а для ідентифікації та кількісного визначення – найчастіше метод рідинної хроматографії з тандемною мас-спектрометрією. Ці методи вимагають дорогого обладнання, використання розчинників, які не завжди є екологічними. Тому розробка нових та вдосконалення вже існуючих аналітичних і біо­аналітичних методик із застосуванням підходів “зеленої” та “білої” хімій є актуальними на даний час. Окрім того, є потреба в розробці методу ізолювання зопіклону, залеплону та золпідему з біологічних об’єктів (печінка, нирка тощо), оскільки ці речовини досить часто спричиняють отруєння зі смертельним наслідком.
Мета дослідження – узагальнити інформацію про існуючі методики виявлення і кількісного визначення зопіклону, золпідему та залеплону в різноманітних об’єктах.
Висновки. Аналіз літературних джерел показав, що розробка і валідація нових та вдосконалення вже існуючих аналітичних і біоаналітичних методик, розробка методів ізолювання з різних об’єктів на даний час є актуальними для проведення хіміко-токсикологічного аналізу та фармацевтичного контролю.
Perfusion Abnormalities on 24-Hour Perfusion Imaging in Patients With Complete Endovascular Reperfusion
Authors: Mujanovic Adnan , Imhof Anick , Zheng Shaokai , Piechowiak Eike I. , Serrallach Bettina L. , Meinel Thomas R. , Dobrocky Tomas , Aziz Yasmin N. , Seiffge David J. , Goeldlin Martina , Arnold Marcel , Hakim Arsany , Wiest Roland , Gralla Jan , Mistry Eva A. , Fischer Urs , Wegener Susanne , Kaesmacher Johannes
Published: August 2024

BACKGROUND:

Perfusion abnormalities in the infarct and salvaged penumbra have been proposed as a potential reason for poor clinical outcome (modified Rankin Scale score >2) despite complete angiographic reperfusion (Thrombolysis in Cerebral Infarction [TICI3]). In this study, we aimed to identify different microvascular perfusion patterns and their association with clinical outcomes among TICI3 patients.

METHODS:

University Hospital Bern’s stroke registry of all patients between February 2015 and December 2021. Macrovascular reperfusion was graded using the TICI scale. Microvascular reperfusion status was evaluated within the infarct area on cerebral blood volume and cerebral blood flow perfusion maps obtained 24-hour postintervention. Primary outcome was functional independence (90-day modified Rankin Scale score 0–2) evaluated with the logistic regression analysis adjusted for age, sex, and 24-hour infarct volume from follow-up imaging.

RESULTS:

Based on microvascular perfusion findings, the entire cohort (N=248) was stratified into one of the 4 clusters: (1) normoperfusion (no perfusion abnormalities; n=143/248); (2) hyperperfusion (hyperperfusion on both cerebral blood volume and cerebral blood flow; n=54/248); (3) hypoperfusion (hypoperfusion on both cerebral blood volume and cerebral blood flow; n=14/248); and (4) mixed (discrepant findings, eg, cerebral blood volume hypoperfusion and cerebral blood flow hyperperfusion; n=37/248). Compared with the normoperfusion cluster, patients in the hypoperfusion cluster were less likely to achieve functional independence (adjusted odds ratio, 0.3 [95% CI, 0.1–0.9]), while patients in the hyperperfusion cluster tended to have better outcomes (adjusted odds ratio, 3.3 [95% CI, 1.3–8.8]).

CONCLUSIONS:

In around half of TICI3 patients, perfusion abnormalities on the microvascular level can be observed. Microvascular hypoperfusion, despite complete macrovascular reperfusion, is rare but may explain the poor clinical course among some TICI3 patients, while a detrimental effect of hyperperfusion after reperfusion could not be confirmed.
The Impact of Stratosphere-to-Troposphere Transport Associated with the Northeast China Cold Vortex on Surface Ozone Concentrations in Eastern China
Authors: Zhu Fangrui , Luo Jiali , Wang Zhenhua , Jin Hong , Zhao Qianfei , Wang Zhiting , Luo Fuhai , Gu Mingzhen
Published: August 2024

As the surface ozone (O3) concentration is increasing despite emission control measures, it is urgent to clarify the impact of dynamic transport, such as quantifying the impact of stratosphere-to-troposphere transport (STT) on the surface O3 budget. Based on observations and numerical models, this study explores the relationship between the surface O3 concentration in eastern China (30°–38°N, 112°–122°E) and the location and intensity of the Northeast China cold vortex (NCCV), a predictable weather system. The results show that when the NCCV occurs in the southeastern region (35°–47.5°N, 125°–140°E), there is a corresponding increase in the surface O3 concentration in eastern China. The stronger the intensity of the NCCV is, the greater the increase in surface O3. The strongest 10% of the NCCV may cause an increase in the surface O3 concentration of 12–18 ppbv (30%–45% of the summer average surface O3 concentration). NCCV events and enhanced O3 are related to the STT. Anomalies in the 200-hPa wind field induce downward motion in the NCCV region and its west side. The cold O3-rich stratospheric air is transported southeastward and downward during the NCCV period, leading to an increase in the surface O3 concentration. The correlation and predictability between 500-hPa meteorological fields and surface O3 concentrations are also highlighted in this work.

Significance Statement

Despite the emission control measures taken in the past, the surface O3 concentration continues to increase in most regions of the world. It is urgent to quantify all the factors that impact the surface O3 concentration. This study focuses on a predictable weather system, the Northeast China cold vortex (NCCV), and its connection with stratosphere-to-troposphere transport (STT) that induces enhanced surface O3 concentrations. Our findings provide a fresh perspective for studying the sources and forecasting of O3 concentrations by linking upper-level weather systems and meteorological fields with changes in surface O3 concentrations.
Photoangiolysis with the 445-nm Blue Laser and the Potassium-Titanyl-Phosphate Laser: A Comparison
Authors: Lin Cong-Kai , Chen Yi-Ping , Wang Yuan-Hung , Dailey Seth H. , Lai Ying-Ta
Published: August 2024

Objectives:

Photoangiolytic lasers have yielded significant innovation in laryngeal surgery in the last 25 years. After the discontinuation of the potassium titanyl phosphate (KTP) laser, a novel 445-nm blue laser was developed. The optimal balance between a laser’s desired tissue effects and collateral tissue damage is a major determinant of laser selection in microlaryngeal surgery. The shell-less incubation system for the chick chorioallantoic membrane (CAM) simulates the microvasculature of the human vocal fold and is useful for testing effects of laser settings and in simulated surgery. The aim of this study is to compare the tissue effects of the KTP and blue lasers using the shell-less CAM model.

Methods:

The shell-less incubation system contains: polymethylpentene film (used as a culture vessel), calcium lactate and distilled water supplementations. By using this system, the chick chorioallantoic membrane (CAM) can be fully exposed with a good field for surgery simulation. The effects of the 2 lasers (532 nm KTP and 445 nm blue) were quantified at clinically relevant energy settings and laser distances from target. Measures included imaging real-time vascular reactions in the CAM model, post-procedure histologic analysis of CAM tissue and temperature changes.

Results:

Vessel coagulation and rupture rates were less common with the blue laser compared with the KTP laser. Histologic analysis demonstrated less tissue disruption with the blue laser. Temperature changes were less with the blue laser.

Conclusion:

In this CAM model with specific conditions, the blue laser reveals less tissue damage than the KTP laser. Suitable working distance and power setting of the laser are necessary for desired tissue effects. Level of Evidence: Level 3.
Transcoding a wanghong city: Mediatized culturalization of urban places in China
Authors: Zou Sheng
Published: August 2024

Digital media have been playing an increasingly pivotal role in reshaping urban spaces, landscapes, and lifestyles across the world. In China, the rapid development of digital infrastructure, platforms, and e-commerce has fueled the rise of a number of so-called wanghong cities. A term originally employed to denote internet celebrities, wanghong as a social phenomenon, practice, and modus operandi now penetrates different spheres of life in China. This article presents a case study of a new wanghong city, Zibo, a third-tier industrial city that rose to sudden fame in 2023 with the aid of livestreaming and short video. Extending Manovich’s idea of “transcoding” between the cultural and the digital, this article investigates how the logics, aesthetics, and sensibilities of digital (social) media increasingly carry over to the “imagineering” of built environment—particularly urban place-making—within interlocking processes of mediatization and culturalization. Mediatized culturalization of urban places in China prompts us to critically reflect on deeper questions around the right to and the future of our cities in the social media era.
Me-Search: Pursuing Race, Culture, and Gender in the Heart and Healing Work of Qualitative Inquiry
Authors: Farinde-Wu Abiola , Butler Bettie Ray
Published: August 2024

We, Abiola and Bettie (sista and mama scholars), editors of this special issue offer an overiew of authors’ works. Here, we welcome you to sit, stay a while, and partake in their collective wisdom, truths, and expereinces. We invite you to allow yourself to become undone and reconnect with self as these authors share their me-searchers in hopes that you, too, will find your “me” in qualitataive research. With love, A & B.
A 6-Week Mindfulness-Acceptance-Commitment Intervention to Improve Professional Ballet Dancers’ Psychological States Around Performance
Authors: Harrison Carly , Ruddock Scott , Mayes Susan , Cook Jill , O’Halloran Paul , Ferrar Katia , Li Xia , Ruddock Mandy
Published: August 2024

Background: Mindfulness and acceptance-based approaches have been trialled in professional sport. The present pilot study was a randomized controlled trial with professional ballet dancers investigating the effectiveness of the Mindfulness-Acceptance-Commitment (MAC) approach, developed for athletes, compared to an education program which included topics relevant to ballet and performance. Methods: Participants included 16 professional ballet dancers (2 men and 14 women) who were randomly assigned into either the MAC or education group for 1 session per week, for 6 weeks. Participants were assessed pre-and post-intervention using the Mindfulness Inventory for Sport (MIS) and the Acceptance Action Questionnaire (AAQ-II). Within 2 weeks of the final mindfulness session, all participants completed a semi-structured interview. Results: No differences were found when comparing the questionnaire responses between pre- and post- intervention, nor between the MAC group and the control group at post intervention for all subscales. Although dancers reported in the interviews that the sessions were valuable, they advised their ability to dedicate time to mindfulness ongoing would be challenging. Conclusions: Mindfulness interventions, as explored in this study, show promise to promote the well-being of professional ballet dancers. For consistent and ongoing mindfulness practice, future designs should seek to embed mindfulness practice into dancer and company schedules.
Unveiling the girl boss sexual contract: A multimodal discourse analysis of female influencers in the United Kingdom, Sweden and Slovenia
Authors: Lukan Tinca , Appleton Marni
Published: August 2024

This article examines the self-representations of three female lifestyle influencers from three different empirical settings – the United Kingdom, Sweden and Slovenia – who are each in their own context referred to as a ‘girl boss’. Drawing on multimodal discourse analysis, we examine what ideas and practices constitute a girl boss. Our analysis shows that, despite different geographies and socio-economic backgrounds, influencers’ self-representations are made up of the same themes that together constitute the girl boss as an ideal feminine subject of the current moment. Drawing on the work of Angela McRobbie, we extend sociological and feminist accounts of postfeminism by arguing that, with neoliberalism entering its maturity stage, the girl boss is a new sexual contract offered to women through four modalities of prescriptive feminine agency: girl boss masquerade, boss babe, power couples and woke girl. We also demonstrate the homogenizing tendencies of Internet culture and how the girl boss ideal is easily transposed from the West to the rest.
In and against the platform: Navigating precarity for Instagram and Xiaohongshu (Red) influencers
Authors: Fan Jiali
Published: August 2024

Existing scholarly discussions of the influencer industry often take a critical stance, marked by a narrow, westernised and homogenised theme of precarity. This raises the need to explore the empirical dynamics of precarity—how it is understood, managed, and ultimately lived for influencers from different social and cultural contexts. Based on in-depth interviews with 15 Instagram influencers and 12 from Xiaohongshu (Red), this article reveals that influencers adopt a positionality I term “in and against the platform.” This approach involves both collaboration with and resistance to platform rules and rituals, ultimately enabling influencers to establish a sustainable way of living amid precarity. I argue that this “in and against” framework as a condition of labour not only highlights the active agency and creativity often overlooked in academic discussions but also complicates our understanding of precarity, opening up new possibilities for coexistence with this condition.
Doing good, doing wrong, doing time and doing harm: Criminalising the marginal in charity shops
Authors: Payson Alida , Fitton Triona
Published: August 2024

This paper builds upon theories of carceral spatiality and criminalisation to explore the extension of the carceral state into everyday spaces. In particular, here we consider the UK charity shop, which not only covertly relies on carceral labour from people ‘doing time’, but also abets the carceral state by criminalising everyday lives on the social and economic margins, thereby doing harm. Moreover, this criminalisation means charity shops become part of a broader system of governing in which social issues are treated as criminal problems with carceral solutions. We draw on ethnographic fieldwork in charity shops and news discourse over more than a decade to consider the pivotal yet hidden role of charity shops as instruments of criminalisation. We explore how charity shops as liminal spaces play a significant role in criminalisation through: sensationalising stories of ‘good’ charities and ‘bad’ criminals; policing theft, scams, and salvage; judging moments of what, and who, is criminal; and guarding against breaches of the terms of penal work orders. We argue that unpicking how charity shops criminalise the marginal matters, particularly in a context of both rising social inequality and the popularity of second-hand spaces, and brings into focus overlooked aspects of carceral power.
Family Life of Parents With Visual Disabilities and Their Sighted Children: How their Families Could Be Empowered From the Social Work Point of View
Authors: Tören Zeliha , Gökçearslan Elif
Published: August 2024

Families with parents with visual disabilities and sighted children continue to be viewed with suspicion and prejudice; however, when suitable conditions are provided, these families can function in a healthy manner. Social work, as a profession, is of great importance in terms of empowering these families. The aim of this article is to understand how such families function. We interrogate how disability affects functioning and consider the circumstances under which healthy family functioning occurs. Interviews were conducted with nine mothers and nine fathers with visual disabilities, and nine sighted children in Türkiye. The findings indicate that family members’ autonomy, their ability to adapt, and the social support they receive play key roles in the existence of a functional, strong family. Finally, suggestions are presented for social workers on how they can help families to make them stronger.
Practices and Barriers to Promoting Educational Equity for Migrant Children in China from the Perspective of a Local Government
Authors: Deng Ruiqi , Gao Yifan
Published: August 2024

Researchers have sought perspectives from students, parents, teachers, and school administrators to investigate the educational status of migrant children. This study sheds new light on the same topic by adopting the perspectives of local government officials. Specifically, it investigates the practices advocated by local governments to improve the educational equity of migrant children and the barriers they may encounter. Face-to-face, semi-structured interviews were conducted with government officials working in a provincial education department in East China. The findings indicated that the practices advocated by the local government showed the following five characteristics: (1) the key practices implemented by the local government were almost exclusively related to migrant children’s access to education, (2) the local government paid greater attention to the primary and lower secondary stages of migrant children’s education, (3) there was no task force dedicated to migrant children’s education, (4) although several government agencies worked on migrant children’s education, the provincial education department played a leading role, and (5) the local government did not work closely with private schools on migrant children’s education because of a lack of trust. Evidence from this study also suggests three key barriers to promoting educational equity: lack of educational resources, uneven distribution of good teachers, and lack of reform of the household registration system. These findings have important implications for re-evaluating policies and practices promoting educational equity for Chinese migrant children at the state and regional levels.
Prevalence of Concomitant Injuries by Sport in Pediatric Patients With ACL Rupture
Authors: Blumenschein Lucas A. , Kolin David A. , Fabricant Peter D. , Park Joshua , Gilmore Allison , Seeley Mark , Mistovich R. Justin
Published: August 2024

Background:

Although the risk of concomitant injury with anterior cruciate ligament (ACL) tears as a function of specific sports participation has been studied in adults, the topic has not been examined in pediatric and adolescent patients.

Purpose/Hypothesis:

The purpose of the study was to determine if certain sports were associated with a higher risk of concomitant injuries in the setting of an ACL tear. It was hypothesized that the risk of concomitant injuries with ACL tears will differ by type of sport participation in the pediatric population.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

Patients ≤18 years old from 2 tertiary children's hospitals who had undergone primary ACL reconstruction between 2006 and 2018 were included. Sport at the time of injury, demographic factors, and injury pattern (medial meniscal [MM] tears, lateral meniscal [LM] tears, posterior cruciate ligament [PCL] tears, medial collateral ligament [MCL] tears, lateral collateral ligament [LCL] tears, and any concomitant injury) were identified.

Results:

A total of 855 patients with a mean age of 15.5 ± 1.7 years (range, 7-22 years) met the inclusion criteria. Of the included patients, 353 (41.3%) had an isolated ACL tear. A concomitant MM tear was identified in 27.6% of patients, LM tear in 42.9%, PCL injury in 0.4%, MCL injury in 3.0%, and LCL injury in 0.5%. There was no difference in the likelihood of concomitant MM injuries by sex (29.3% for male patients vs 26% for female patients; P = .31) or by sex within basketball (29.3% for male patients vs 25.6% for female patients; P = .96) or soccer (32.3% vs 26.3%; P = .06). Boys had higher proportions of LM injuries overall (51.7% for male patients vs 34.6% for female patients; P < .001) but not within the basketball subgroup (50.5% vs 40.0%; P = .86) or the soccer subgroup (59.7% vs 40.0%; P = .19). No statistically significant associations were found between patient age and specific ACL concomitant injury patterns. When stratifying by body mass index, it was found overweight and obese individuals constituted a greater proportion of LM (49.6% vs 39.1%; P = .01) but not MM (29.4% vs 25.5%; P = .28) injuries when compared to normal-weight patients. Using basketball as the comparison group, soccer and football injuries were 18% more likely to result in any concomitant injury, including concomitant MM, LM, PCL, MCL, and LCL injuries.

Conclusion:

In the pediatric population, soccer and football players were more likely to present with a concomitant injury in addition to ACL injury relative to basketball players. This study aids in understanding sport-associated ACL injury patterns and can help physicians with patient counseling and injury prevention.
Impaired Symmetry in Single-Leg Vertical Jump and Drop Jump Performance 7 Months After ACL Reconstruction
Authors: Giacomazzo Quentin , Picot Brice , Chamu Thomas , Samozino Pierre , Pairot de Fontenay Benoit
Published: August 2024

Background:

Anterior cruciate ligament reconstruction (ACLR) continues to be associated with a variable rate of return to sports and a concerning rate of further anterior cruciate ligament injury. Persistent functional deficits may explain these results and support the need to keep exploring lower limb functional indexes, especially during vertical jumping. This would help improve rehabilitation through the return-to-sports continuum and improve postoperative outcomes.

Hypothesis:

Vertical jumping performance indexes are impaired among patients 7 months after ACLR.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

A total of 202 patients who underwent ACLR and 50 healthy participants performed single-leg vertical jump (SLVJ) and single-leg drop jump (SLDJ) testing. Jump height (H) as well as reactive strength index (RSI) were assessed and the limb symmetry index (LSI) of each parameter was compared between both groups. Vertical jumping indexes were also compared between healthy participants and the injured and contralateral legs of ACLR patients. Frequency analysis (chi-square test) of participants exhibiting an LSI >90% for each parameter was calculated in both groups. The level of association between SLVJ-H, SLDJ-H, and SLDJ-RSI was evaluated using the Pearson coefficient ( r).

Results:

At 6.6 ± 0.7 months (mean ± SD) postoperatively, participants after ACLR exhibited poorer LSI than the control group for all parameters (79.1 ± 14.8 vs 93.9 ± 4.5, 77.3 ± 14.6 vs 93.4 ± 5.2, and 71.9 ± 17.4 vs 93.4 ± 3.8; all P < .001; for the SLVJ-H, SLDJ-H, and SLDJ-RSI, respectively). Vertical jumping performance was lower on both injured and contralateral legs compared with healthy participants (all P < .001). Only 27%, 25%, and 16% of the ACLR patients exhibited an LSI >90% for the SLVJ-H, SLDJ-H, and SLDJ-RSI, respectively, in comparison with 80%, 72%, and 86% in the control group. Moderate correlations were observed between SLDJ-H and SLVJ-H ( r = 0.494; P < .001) as well as between SLDJ-RSI and SLVJ-H ( r = 0.488; P < .001) in the ACLR group.

Conclusion:

Vertical jumping indexes (both symmetry and absolute values) were highly impaired 7 months after ACLR. Deficits were more marked for reactive strength ability. Clinicians should focus on restoring vertical jumping abilities to improve functional performance after ACLR.
Paper 16: Long-term Outcomes of Primary Hip Arthroscopy: Multicenter Analysis at Minimum 10-Year Follow-Up with Attention to Labral and Capsular Management
Authors: Hevesi Mario , Boos Alexander , Wang Allen , Lamba Abhinav , Okoroha Kelechi , Ortiguera Cedric , Levy Bruce , Krych Aaron , Pan Xuankang , Clark Sean , Meta Fabien
Published: August 2024

Objectives:

Hip arthroscopy is rapidly advancing, with literature increasingly reporting positive outcomes at short- and mid-term follow-up; however, available long-term data remains limited. The purpose of this study is to evaluate long-term outcomes of primary hip arthroscopy at minimum 10-year follow-up at two academic centers by describing patient-reported outcomes (PROs) and determining reoperation, revision, and total hip arthroplasty (THA) rates.

Methods:

Primary hip arthroscopies performed between January 1988 and April 2013 at 2 academic centers were evaluated for postoperative PROs including Visual Analogue Scale (VAS), Tegner Activity Scale score, Hip Outcome Score Activities of Daily Living and Sport Scale (HOS-ADL/HOS-SS), modified Harris Hip Score (mHHS), Nonarthritic Hip Score (NAHS), 12-item International Hip Outcome Tool (iHOT-12), surgery satisfaction, function, and reoperations.

Results:

Two-hundred ninety-four primary hip arthroscopies with a mean age of 40±14 years; 66% female; and a mean body mass index (BMI) of 27±6 kg/m2 were followed for mean 12±3 years (range: 10-24). Labral debridement and repair were performed in 41% and 59% of patients, respectively. All patients underwent interportal capsulotomy and 2% underwent T-capsulotomy. Eleven percent of patients underwent capsular repair. At final follow-up, patients reported mean VAS at rest of 2±2, with use of 3±3, iHOT-12 of 68±27, NAHS of 81±18, mHHS of 79±17, HOS-ADL of 82±19, and HOS-SS of 74±25. Mean surgical satisfaction was 8.4±2.4 (Table 1). Sixty-five hips (23%) underwent THA and 33 (11%) underwent revision arthroscopy (Table 2). Risk factors for THA included older age (p<0.001), higher BMI (p<0.001), lower lateral center-edge angle (p=0.039), larger alpha angle (p=0.001), higher Tönnis grade (p=0.011), labral debridement (p=0.004), and capsular nonrepair (p=0.030). Patients undergoing combined labral and capsular repair demonstrated a THA conversion rate of 3% compared to 31% for patients undergoing combined labral debridement and capsular nonrepair (p=0.006) (Table 3). Labral repair trended towards increased 10-year THA-free survival (84% vs. 77%, p=0.085) while capsular repair demonstrated significantly increased 10-year THA-free survival (97% vs 79%, p=0.032) (Figure 1).

Conclusions:

At minimum 10-year follow-up, patients undergoing primary hip arthroscopy demonstrated high rates of satisfaction and acceptable outcome scores. In total, 11% of patients underwent revision hip arthroscopic surgery with a THA conversion rate of 23%. Conversion to THA was associated with patient factors including older age and higher Tönnis grade as well as potentially modifiable surgical factors including labral debridement and capsular nonrepair.
Poster 142: Location of Shoulder Glenoid Labral Tears: A Study of 1763 Consecutive Patients
Authors: Nammour Michael , Mohr Damaris , Arner Justin , Bradley James
Published: August 2024

Objectives:

To examine the location of surgically repaired labral tears by a single surgeon over a consecutive 23-year period.

Methods:

A total of 1763 consecutive patients who underwent arthroscopic or open shoulder labral repair by a single sports medicine fellowship trained orthopedic surgeon were retrospectively reviewed between April 2000 and April 2023. Current procedural terminology codes were utilized to identify patients which included 29806, 29807, 29822, and 29823. Exclusion criteria included isolated shoulder manipulation or glenohumeral joint or labral debridement which did not include repair. Intraoperative glenoid labral tears observed were categorized into 6 broad categories which included (1) anterior labral tears, (2) posterior labral tears, (3) superior labral anterior to posterior (SLAP) type 2 tears (a, b, or c), (2) SLAP type 5 tears, (3) SLAP type 8 tears, or circumferential tears (combined SLAP, anterior and posterior labral tear). Shoulders diagnosed with multiple tear patterns (ie anterior and posterior) were also noted.

Results:

During the 23-year period, 1763 patients underwent arthroscopic or open labral repair which included 1295 male patients and 468 female patients, ranging from ages 12 to 70, with a mean age of 23.2 and median age of 19. Overall, 28.4% of tears involved the anterior labrum, 64.9% involved the posterior labrum, and 59.7% involved the superior labrum. Regarding isolated tears, 9.25% were isolated anterior labral tears, 19.7% were isolated posterior labral tears, 11.4% involved the anterior and posterior labrum, 22.2% were isolated SLAP type 2 tears, 3.63% were isolated SLAP type 5 tears, and 29.7% were isolated SLAP type 8 tears, and 4.01% were circumferential tears.

Conclusions:

In contrast to historic ideology, posterior shoulder labral tearing was more common than anterior in a large consecutive series of 1763 patients who underwent surgical repair. This highlights the importance of posterior labral pathology which sometimes may be overlooked due to more vague complaints, including pain and loss of function, being most common.
Poster 196: Comparison of Short-Term Outcomes Following Hip Arthroscopy With Labral Repair Versus Labral Augmentation
Authors: Fasulo Sydney , Marder Ryan , Nadeau Nicolas , Richards Sean , Nugent Robert , Dave Neil , Maguire James , Kraeutler Matthew , Scillia Anthony
Published: August 2024

Objectives:

The treatment of labral pathology during hip arthroscopy has evolved over the last decade or more. Recently, the use of labral augmentation or reconstruction with allograft for the treatment of irreparable or tissue-deficient labral pathology has demonstrated favorable outcomes. The purpose of this study was to compare the clinical outcomes of patients undergoing hip arthroscopy with labral repair (LR) versus labral augmentation (LA).

Methods:

A prospective, single-surgeon cohort study was performed on all patients undergoing hip arthroscopy with LR or LA between September 2019 and April 2022. For patients with labral deficiency or a hypotrophic labrum, labral augmentation was performed by addition of iliotibial band allograft to a segment of the repair construct. An electronic survey of patient-reported outcome measures (PROMs) was completed by each patient at a minimum of 1-year postoperatively. PROMs included a visual analog scale (VAS) for pain, University of California - Los Angeles (UCLA) Activity Scale, modified Harris Hip Score (mHHS), Hip Outcome Score-Sport (HOS-Sport), and a Single Assessment Numeric Evaluation (SANE).

Results:

Seventy-nine patients were reached for follow-up (52 LR, 27 LA). No differences were found between the LR and LA groups in terms of age at surgery (34 ± 13 vs 38 ± 13 years, p = 0.15), sex (52% vs 74% female, p = 0.09), or body mass index (26 ± 7 vs 24 ± 5 kg/m2, p = 0.22). Due to a more recent adoption of the LA technique to the senior surgeon’s practice, there was a significantly longer time to follow-up in the LR group (LR: 26 ± 8 months, LA: 20 ± 7 months, p < 0.001). There was a significantly higher HOS-Sport (80.7 ± 21 vs 67.9 ± 33, p=0.04) and SANE (86.7 ± 16 vs 74.4 ± 29, p = 0.02) in the LR group. However, there were no significant differences between groups in other postoperative PROMs including VAS (2.1 ± 2.1 vs 3.0 ± 2.8, p = 0.10), UCLA Activity Scale (7.8 ± 2 vs 7.3 ± 3, p = 0.35), and mHHS (78.6 ± 13 vs 72.5 ± 17, p = 0.09).

Conclusions:

Our study identified mixed short-term functional outcomes when comparing the use of labral augmentation to labral repair in a young and active population. With the evolution of hip arthroscopy and advancements in surgical technique, our study does support the cautious use of labral augmentation when indicated. Larger studies are warranted to corroborate these findings.
Poster 198: Patient Satisfaction 2 Years After Hip Arthroscopy for Femoroacetabular Impingement Syndrome Predicts 10-Year Outcomes
Authors: Wright-Chisem Joshua , Alvero Alexander , Vogel Michael , Nho Shane
Published: August 2024

Objectives:

To evaluate if patient satisfaction 2 years after primary hip arthroscopy for femoroacetabular impingement syndrome (FAIS) predicts 10-year minimum patient-reported outcomes (PROs), clinically significant outcomes, and survivorship.

Methods:

Patients who underwent primary hip arthroscopy for FAIS between June 2012 and December 2012 with minimum 10-year follow-up were identified. Patients were partitioned into High Satisfaction and Low Satisfaction groups based on their achievement of Patient Acceptable Symptom State (PASS) for visual analog scale for satisfaction (VAS-Satisfaction) at 2 years postoperatively using a previously defined PASS threshold for VAS-Satisfaction. Ten-year minimum PRO scores were then compared between the groups, including Hip Outcome Score – Activities of Daily Living (HOS-ADL) subscale and Hip Outcome Score – Sport Specific (HOS-SS) subscale, modified Harris Hip Score (mHHS), visual analog scale for pain (VAS-P) subscale, and VAS-Satisfaction. Achievement of 10-year PASS for HOS-ADL, HOS-SS, mHHS, VAS-P, and VAS-Satisfaction were compared between groups. Kaplan-Meier survival analysis was used to compare reoperation-free survivorship between groups.

Results:

Of the 120 consecutive eligible patients, 85 were included (70.8% compliance) with an average age of 34.0 ± 12.8 years, 60.9% female, and an average BMI of 25.4 ± 4.6 kg/m2. Fifty-six patients achieved PASS for VAS-Satisfaction at 2 years postoperatively, and 29 did not. No significant demographic differences were observed between groups (p ≥ 0.357). At 10-year follow up, the High Satisfaction group demonstrated significantly greater HOS-ADL, HOS-SS, mHHS, VAS-P, and VAS-Satisfaction scores (p ≤ 0.031, for all) and significantly greater PASS achievement for all PROs (p ≤ 0.015, for all). Kaplan-Meier survival analysis demonstrated significantly greater reoperation-free survivorship for the High Satisfaction group (p < 0.001) with a significantly lower rate of reoperation (1.8% vs. 24.1%, p = 0.002).

Conclusions:

Patients who achieved PASS for VAS-Satisfaction 2 years after hip arthroscopy for FAIS showed superior 10-year minimum patient-reported outcomes, higher achievement of 10-year PASS, and a lower reoperation rate compared to those who did not achieve PASS for VAS-Satisfaction at 2 years.
Poster 272: Age-Based Differences in Characteristics of Pediatric Discoid Lateral Meniscus
Authors: Niu Emily , Sheasley Jennifer , Gopalan Maya , Gupta Apeksha , Carsen Sasha , Stinson Zachary , Finlayson Craig , Nault Marie-Lyne , Lee Rushyuan J. , Haus Brian , Green Daniel W. , Schlechter John , Heyworth Benton E. , Beck Jennifer , Nguyen Jie , Schmale Gregory A.
Published: August 2024

Objectives:

Discoid lateral meniscus (DLM) in pediatric patients presents across a broad age range. It is unknown whether clinical presentation and DLM morphology differ between age groups. This study investigates age-based differences in DLM characteristics from a multi-center retrospective database of DLM. We hypothesize that there are predictable differences in presentation and DLM morphology between age groups.

Methods:

This retrospective study included surgically treated DLM patients between January 2000 and March 2020 from 9 centers in North America. Patients’ demographic and clinical characteristics were collected. Statistical analysis was performed to compare characteristics of DLM between age groups: < 7, 7-10, 11-13, 14-16, and ≥ 17 years. Kruskal-Wallis test and Chi-square or Fisher Exact test were used to compare age groups for continuous and categorical variables, respectively. Statistical significance was defined as p-value < 0.05.

Results:

868 patients with mean age 12 years (range: 1-22 years) were included for analysis. More patients were female (57%) than male, especially in the younger age groups. The proportion of patients in each age group: <7 years (7.6%), 7-10 years (25.8%), 11-13 years (28.2%), 14-16 years (25.2%), ≥17 years (13.1%). Patients <7 years had significantly longer duration from initial presentation to surgery (median 214 days vs ≥17 years 28.5 days; p<0.05). Among patients <7 years, over 40% presented with a complaint of either “snapping” or “clunking.” Meanwhile, patients aged ≥17 years more commonly presented with complaints of swelling (33%) and locking (44%) [Figure1]. Incidence of discoid meniscus tear was highest among patients ≥17 years (80.7%), and lowest among <7 years (56.1%). Among patients with tear (N=648), patients ≥17 years were significantly more likely to have radial and parrot beak tears compared to other age groups (radial 18.5%, parrot beak 7.6%; Table 1). Patients 13 and under were more likely to have stiffness on exam (18%-25%) compared to patients 14 years and older (10%-13%; p<0.05). During surgery, patients 13 years and younger were more likely than older patients to have instability of the meniscus (41%-48% vs 26%-30%; p<0.05) and meniscus repair (46%-48% vs 32%-33%; p<0.05).

Conclusions:

Younger patients tend to present with “clunking” DLM and do not typically proceed acutely to surgery. They are more likely to have preoperative stiffness and instability, and more likely to undergo meniscus repair. Older patients are more likely to have a tear, and receive more acute treatment, though repair Is less frequent. These age-based differences in presentation and characteristics of DLM are important in counseling these patients and treatment decision-making.
Poster 289: Impact of Graft Selection on Clinical Outcomes following Isolated MPFL Reconstruction in Adolescent and Young Adult Athletes
Authors: Tisano Breann , Quinn Michael , Warner Tyler , Kramer Dennis E. , Yen Yi-Meng , Kocher Mininder S. , Heyworth Benton E.
Published: August 2024

Objectives:

Patellofemoral instability (PFI) commonly requires surgical intervention in adolescent and young adult athletes. However, the clinical impact of graft selection, which may vary amongst surgeons, has not been well studied. The purpose of this study was therefore to compare clinical outcomes, including recurrent instability reoperations and complications, of medial patellofemoral ligament reconstruction (MPFLR), based on graft type.

Methods:

Electronic medical records of patients who underwent primary MPFLR surgery for PFI over a 10-year period between 2010 and 2019 at a single center were retrospectively reviewed. Collected data included demographic, clinical, and radiologic parameters of instability and post-operative clinical outcomes. Exclusion criteria included concomitant extensor realignment procedures (tibial tubercle osteotomy, patellar tendon transfer procedures) and factors that would alter routine surgical indications or technical approaches, such as fixed or syndromic PFI, osteochondral shear fractures undergoing fixation or >1 cm in diameter, and prior ipsilateral knee surgery.

Results:

One-hundred and one patients (average age 15.2 years, 63% female), underwent primary isolated MPFLR with an average follow up time of 2.87 years. There were no significant differences in demographic and radiographic parameters between autograft and allograft, other than more semitendinosus grafts, increased number of pre-op dislocation events, and higher sulcus angle in autograft (Table 1). The autograft group had a higher rate of recurrent instability (41% vs 14%, p = 0.01) but no significant difference in return to sport, complications, and reoperations (Table 2). Reoperations for recurrent instability were performed in 9% of all patients (Table 3). Subgroup analysis of allograft tendon type demonstrated more dislocations and recurrent instability in gracilis than semitendinosus, though these differences were not statistically significant, and there was no difference in recurrent instability surgery or complications (Table 4).

Conclusions:

In adolescent and young adult athletes undergoing isolated primary MPFLR for PFI, allograft may be associated with decreased rates of recurrent instability compared to autograft. While trends towards higher recurrent instability were detected with gracilis allograft, compared to semitendinosus allograft, the precise role of allograft tendon type would benefit from future studies with larger sample size to better elucidate its impact on clinical outcomes.
Poster 291: Entry Point-Transition Point Angle as a Novel 3-Dimensional Metric of Patellar Instability
Authors: Park Nancy , Sieberer Johannes , Rancu Albert L. , Manafzadeh Armita , McDonald Curtis , Yu Kristin , Wiznia Daniel , Fulkerson John P.
Published: August 2024

Objectives:

Three-dimensional (3D) modeling has increasing utility in identifying differences in trochlear morphology in patients with patellar instability when compared to historical 2-dimensional (2D) attempts. Distortions in the proximal medial ridges of trochleas are a distinguishing feature of trochlear dysplasia. Recently, the entry-point to transition-point (EP-TP) angle was established as a novel 3D metric to quantify degree of dysplasia, as it captures the tracking of the patella within the trochlea. However, previous attempts relied on 3D prints, which are not widely accessible. The purpose of this study is to validate this new measurement and compare differences between patients with patellar instability and the general population.

Methods:

Forty-three patients with recurrent patellar dislocations who were treated by a single surgeon between January 2020 and July 2023 were included. The study received an institutional review board exemption. Individuals from the New Mexico Decedent Image Database with no history of patellar instability or patellofemoral pain were used to obtain computed tomography (CT) images from the general population. Stereolithography (STL) models of distal femurs in 3D were generated from CT images using ScanIP. Minimum and maximum principal curvature maps were taken as screenshots from maps generated in MeshLab. Two people independently conducted measurements using a custom measuring tool displaying anteroposterior views and curvature maps of the distal femur. The measurers were asked to locate the medial and lateral ridges, transition point, and apex of the trochlea groove for each femur. A Mann–Whitney U test was performed to evaluate whether the recurrent dislocators had higher EP-TP values. P values below 0.01 were regarded as significant. Interclass correlation for both raters (ICC (1, k), reliability of values within this study) and single rater (ICC (1,1), reliability of measurement within clinical practice) and the 95% CI thereof, was computed for the 2 independent measurements.

Results:

A total of 100 femurs were measured, including 43 recurrent dislocators and 57 population femurs. The recurrent dislocator cohort had a mean EP-TP of 40.9° with a standard deviation of 16.4°. The general population cohort had a mean EP-TP of 11.3° with a standard deviation of 12.3°. EP-TP for dislocators and general population was significantly different. (p < 0.001). ICC (1, k) was 0.81 with a 95%-confidence interval of 0.72 to 0.87. ICC (1,1) was 0.69 with a 95% CI of 0.57 to 0.78.

Conclusions:

EP-TP angle is a novel metric that helps quantify trochlear dysplasia, which can help clinicians better understand patellar instability. In this study, we validate EP-TP angle by showing that EP-TP angle was significantly different between femurs of recurrent dislocators and the general population.
Poster 297: Clinical Outcomes and Return to Sports After Revision ACL Reconstruction With Lateral Extraarticular Tenodesis: Comparison to A Control Group of ACL Reconstruction Only at a Minimum 2-Year Follow-Up
Authors: Gould Heath P. , Eliasberg Claire D. , Adamec Dakota , James Evan W. , Marx Robert G. , Allen Answorth A. , Cordasco Frank A. , Nwachukwu Benedict U. , Nawabi Danyal H.
Published: August 2024

Objectives:

Lateral extraarticular tenodesis (LET) has been shown to decrease failure rate in settings of revision anterior cruciate ligament (ACL) reconstruction in young, high-demand patients. However, there is a paucity of literature comparing clinical outcomes and return to sports after patients who undergo revision ACL reconstruction LET compared to those without LET (control group).

Methods:

All patients who underwent revision ACL reconstruction with and without LET between January 2018 and February 2020 were queried at our institutional registry. The LET group was compared to the control group (revision ACL reconstruction without LET) were followed for a minimum of 24 months postsurgery to evaluate patients reported outcome measures, satisfaction, return to sports, rate of reoperation, and psychological readiness for return to sports (using the ACL-Return to Sport After Injury Scale, ACL-RSI).

Results:

A total of 81 patients with a mean follow-up of 2.75 years were included. The LET group contained 37 patients (76% female) with a mean age of 26.6 years and body mass index (BMI) of 23.5 kg/m^2 compared to 44 patients (80% female) with mean age of 28.2 years and BMI of 26.9 kg/m^2. There were no significant differences between the LET and control groups with respect to mean postoperative Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference (47.7 vs 48.3, p = 0.46) and PROMIS Mobility scales (53.3 vs 52.9, p = 0.97). In addition, there were no differences in postoperative International Knee Documentation Committee (78.9 vs 78.3, p=0.45), Marx (7.9 vs 7.2, p = 0.64), or Single Assessment Numeric Evaluation (73.1 vs 74.2, p = 0.38) scores. The same held true with regards to postoperative ACL-RSI scores between the groups (43.3 vs 50.1, p = 0.38). Return to play rates after revision ACL were similar in the LET group compared to the control group (55% vs 45%, p = 0.40) with similar confidence to play their pre-injury sport (scale out of 100, 58.2 vs 56.2, p = 0.82). Lastly, overall reoperation rates were similar between the groups with the LET group having a rate of 21.2% compared to 19.4% for the control group. When isolated for revision due to graft tear, the LET group had a re-revision rate of 13.5% compared to 6.8% in the control group (p = 0.31).

Conclusions:

Satisfaction and patient reported outcome scores after revision ACL reconstruction are good with or without LET. While both groups have similar rates of return to play and reoperation at greater than 2- year follow-up, these results suggest the addition of LET may provide similar outcomes in high-risk patients when compared to isolated revision ACL reconstruction.