bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of a d-lyxose isomerase from Bacillus velezensis and its application for the production of d-mannose and l-ribose
Authors: Guo Zongren , Long Liangkun , Ding Shaojun
Published: September 2019

d-Mannose andl-ribose are two important monosaccharides, which have attracted public attention recently because of their great application potentials in food, cosmetic and pharmaceutical industries. Sugar isomerases catalyze the sugar isomerization and therefore can be used as the biocatalysts for production of the high-value sugars from inexpensive sugars.l-arabinose isomerase catalyzes the conversion ofl-arabinose tol-ribulose, whiled-lyxose isomerase catalyzesl-ribulose andd-fructose tol-ribose andd-mannose, respectively. In this paper, a putatived-LI fromBacillus velezensis(BvLI) was identified, characterized and used to produced-mannose andl-ribose fromd-fructose andl-arabinose, respectively. The recombinant BvLI exhibited a maximum activity at 55 °C and pH 6.5, in the presence of 0.1 mM Co2+. Approximately 110.75 g/Ld-mannose was obtained from 500 g/Ld-fructose in 6 h by the recombinant BvLI, and approximately 105 g/Ll-ribose was obtained from 500 g/Ll-arabinose in 8 h by the successive biocatalysis ofl-arabinose isomerase fromBacillus licheniformis(BlAI) and BvLI.
Identification of RUNX2 variants associated with cleidocranial dysplasia
Authors: Gao Xueren , Li Kunxia , Fan Yanjie , Sun Yu , Luo Xiaomei , Wang Lili , Liu Huili , Gong Zhuwen , Wang Jianguo , Wang Yu , Gu Xuefan , Yu Yongguo
Published: September 2019

Background

Cleidocranial dysplasia (CCD) is a rare autosomal dominant disorder mainly characterized by hypoplastic or absent clavicles, delayed closure of the fontanelles, multiple dental abnormalities, and short stature. Runt-related transcription factor 2 (RUNX2) gene variants can cause CCD, but are not identified in all CCD patients.

Methods

In this study, we detected genetic variants in seven unrelated children with CCD by targeted high-throughput DNA sequencing or Sanger sequencing.

Results

All patients carried a RUNX2 variant, totally including three novel pathogenic variants (c.722_725delTGTT, p.Leu241Serfs*8; c.231_232delTG, Ala78Glyfs*82; c.909C > G, p.Tyr303*), three reported pathogenic variants (c.577C > T, p.Arg193*; c.574G > A, p.Gly192Arg; c.673 C > T, p.Arg225Trp), one likely pathogenic variant (c.668G > T, p.Gly223Val). The analysis of the variant source showed that all variants were de novo except the two variants (c.909C > G, p.Tyr303*; c.668G > T, p.Gly223Val) inherited from the patient’s father and mother with CCD respectively. Further bioinformatics analysis indicated that these variants could influence the structure of RUNX2 protein by changing the number of H-bonds or amino acids. The experimental result showed that the Gly223Val mutation made RUNX2 protein unable to quantitatively accumulate in the nucleus.

Conclusions

The present study expands the pathogenic variant spectrum of RUNX2 gene, which will contribute to the diagnosis of CCD and better genetic counseling in the future.
Fluid detection in carbonate rocks by integrating well logs and seismic attributes
Authors: Saberi Mohammad Reza
Published: September 2019

Prestack seismic attributes are efficient tools for hydrocarbon exploration and pore fluid detection with the help of various techniques, such as amplitude variation with offset analysis. Such studies focus mainly on siliciclastics rather than carbonates because detection of fluid effects in carbonate rocks can be masked by their complex pore structure and heterogeneity. Current fluid detection methods from seismic attributes usually rely on a linear background model for P- and S-wave velocities of the water-saturated rocks, and any deviation from this trend is assigned to possible pore fluid changes. This means that the false (or even missed) effect of fluids can be detected in carbonate rocks if inappropriate fluid detection attributes (such as the ones designed for siliciclastics) are used. This is mainly due to the varying pore structure in carbonates, which can make their background model (the model for fully water-saturated rock) mainly nonlinear. I observed that this nonlinearity in the carbonates background model becomes more linear by using P-velocity squared versus the product of the P- and S-velocities crossplot instead of P-velocity versus S-velocity crossplot. Furthermore, I used this proposed crossplot to define a more appropriate background model for my carbonate sequence containing some percentages of gas. I derived a new seismic fluid attribute based on the proposed background model, and I compared the results with various other fluid factors. My results highlight fluid changes more brightly and consistently than existing alternatives for carbonate environments.
“The Harder I Swim, the Faster I Sink”
Authors: Wielgus Alison
Published: September 2019

This essay considers the role that Jane Campion’s Top of the Lake (BBC/SundanceTV, 2013) and Top of the Lake: China Girl (BBC/SundanceTV, 2017) play in the post-network television landscape. Situating the series among the globalized genre of serialized post-network crime shows that feature female detectives, this essay argues that Campion reworks the genre’s fascination with victimized women from her auteurist and Antipodean perspective. While the characterization and actions of the female detective resonate with other programs’ protagonists, Campion challenges dominant discourses of victimized women by intervening in the global circulation of women’s bodies on television. By drawing on Zoë Sofia’s work on female bodies and container technologies, this essay argues that Campion’s use of pregnant victims and her exploration of a female detective’s history as a survivor of sexual assault allow her to interrogate the typical treatment of female corpses within crime television. Through circuitous investigations that leave enough narrative space for detours like the settling of Paradise, where women transform shipping containers into domestic spaces for struggling women, Campion provides a countermodel to crime television focused on forensic progress through a case. Campion similarly takes the container of serialized crime drama that circulates the globe in a post-network television landscape and creates space for women’s stories from the Antipodes. Pausing the narrative to indict the treatment of female victims, Campion also unearths the melodramatic underpinnings of serialized crime dramas that resonate with her own filmography.
Hippo signalling during development
Authors: Davis John Robert , Tapon Nicolas
Published: September 2019

The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first came to attention because of their role in tissue growth control. Over the past 15 years, it has become clear that, like other developmental pathways (e.g. the Wnt, Hedgehog and TGFβ pathways), Hippo signalling is a ‘jack of all trades’ that is reiteratively used to mediate a range of cellular decision-making processes from proliferation, death and morphogenesis to cell fate determination. Here, and in the accompanying poster, we briefly outline the core pathway and its regulation, and describe the breadth of its roles in animal development.
Brain cooling marginally increases acute upper thermal tolerance in Atlantic cod
Authors: Jutfelt Fredrik , Roche Dominique G. , Clark Timothy D. , Norin Tommy , Binning Sandra A. , Speers-Roesch Ben , Amcoff Mirjam , Morgan Rachael , Andreassen Anna H. , Sundin Josefin
Published: September 2019

Physiological mechanisms determining thermal limits in fishes are debated but remain elusive. It has been hypothesised that motor function loss, observed as loss of equilibrium during acute warming, is due to direct thermal effects on brain neuronal function. To test this, we mounted cooling plates on the heads of Atlantic cod (Gadus morhua) and quantified whether local brain cooling increased whole-organism acute upper thermal tolerance. Brain cooling reduced brain temperature by 2-6°C below ambient water and increased thermal tolerance by 0.5 and 0.6°C on average relative to instrumented and uninstrumented controls, respectively, suggesting that direct thermal effects on brain neurons may contribute to setting upper thermal limits in fish. However, the improvement in thermal tolerance with brain cooling was small relative to the difference in brain temperature, demonstrating that other mechanisms (e.g., failure of spinal and peripheral neurons, or muscle) may also contribute to controlling acute thermal tolerance.
An appetite for invasion: digestive physiology, thermal performance, and food intake in lionfish (Pterois spp.)
Authors: Steell S. Clay , Van Leeuwen Travis E. , Brownscombe Jacob W. , Cooke Steven J. , Eliason Erika J.
Published: September 2019

Species invasions threaten global biodiversity, and physiological characteristics may determine their impact. Specific dynamic action (SDA; the increase in metabolic rate associated with feeding and digestion) is one such characteristic, strongly influencing an animal's energy budget and feeding ecology. We investigated the relationship between SDA, scope for activity, metabolic phenotype, temperature, and feeding frequency in lionfish (Pterois spp.), an invasive species to western Atlantic marine ecosystems. Intermittent-flow respirometry was used to determine SDA, scope for activity, and metabolic phenotype at 26°C and 32°C. Maximum metabolic rate occurred during digestion, as opposed to exhaustive exercise as in more athletic species. SDA and its duration (SDAdur) was 30% and 45% lower at 32°C than 26°C, respectively, and lionfish ate 42% more at 32°C. Despite a 32% decline in scope for activity from 26°C to 32°C, aerobic scope may have increased by 24%, as there was a higher range between standard metabolic rate (SMR) and peak SDA (the maximum postprandial metabolic rate). Individuals with high SMR and low scope for activity phenotypes had a less costly SDA and shorter SDAdur but a higher SDApeak. Feeding frequently had a lower and more consistent cost than consuming a single meal, but increased SDApeak. These findings demonstrate that: 1) lionfish are robust physiological performers in terms of SDA and possibly aerobic scope at temperatures approaching their thermal maximum, 2) lionfish may consume more prey as oceans warm with climate change, and 3) metabolic phenotype and feeding frequency may be important mediators of feeding ecology in fish.
Cardiac influence of the β3-adrenoceptor in the goldfish (Carassius auratus): a protective role under hypoxia?
Authors: Leo Serena , Gattuso Alfonsina , Mazza Rosa , Filice Mariacristina , Cerra Maria Carmela , Imbrogno Sandra
Published: September 2019

The goldfish (Carassius auratus) exhibits a remarkable capacity to survive and remain active under prolonged and severe hypoxia, representing a well-suited model to study cardiac function when oxygen availability represents a limiting factor. Under hypoxia, the goldfish heart increases its performance, this representing a putative component of hypoxia tolerance; however, underlying mechanisms have not been yet elucidated. We aimed to investigate the role of β3-ARs in the mechanisms which modulate the goldfish heart performance, also in relation to oxygen levels. By western blotting analysis, we found that the goldfish heart expresses β3-ARs, and this expression increases under hypoxia. Effects of β3-ARs stimulation were analysed by using an ex vivo working heart preparation. Under normoxia, the β3-ARs selective agonist BRL37344 (10−12-10−7M) elicited a concentration-dependent increase of contractility abolished by the specific β3-AR antagonist (SR59230A; 10−8M), but not by α/β1/β2-ARs inhibitors (phentolamine, nadolol, and ICI118,551; 10−7M). Under acute hypoxia, BRL37344 did not affect the goldfish heart performance. However, SR59230A, but not phentolamine, nadolol, and ICI118,551, abolished the time-dependent enhancement of contractility which characterizes the hypoxic goldfish heart. Under both normoxia and hypoxia, adenylate cyclase and cAMP were found to be involved in the β3-ARs-dependent downstream transduction pathway. Our findings suggest the presence of functional β3-ARs in the goldfish heart, whose activation modulates the basal performance and contributes to the hypoxia-dependent increase of contractility.
Regional Dynamic Traffic Assignment Framework for Macroscopic Fundamental Diagram Multi-regions Models
Authors: Batista S. F. A. , Leclercq Ludovic
Published: September 2019

In this paper, we propose a regional dynamic traffic assignment framework for macroscopic fundamental diagram (MFD) models that explicitly accounts for trip length distributions. The proposed framework considers stochasticity on both the trip lengths and the regional mean speed. Consequently, we can define utility functions to assess the cost on alternatives, depending on which terms are considered stochastic. We propose a numerical resolution scheme based on Monte Carlo simulations and use the method of successive averages to solve the network equilibrium. Based on our test scenarios, we show that the variability of trip lengths inside the regions cannot be neglected. Moreover, it is also important to consider the stochasticity on the regional mean speeds to account for correlation between regional paths. We also discuss an implementation of the proposed dynamic traffic assignment framework on the sixth district of the Lyon network, where trip lengths are explicitly calculated. The traffic states are modeled by considering the accumulation-based MFD model. The results highlight the influence of the variability of trip lengths on the predicted traffic states.
Responsible prescribing for cosmetic procedures
Authors: Sines David
Published: September 2019

This article sets out the Jount Council for Practitioners/Cosmetic Practice Standards Authority position regarding responsible prescribing of POMs used in aesthetic practice. The guidance accords with that set down by the majority of the healthcare professional regulators and by the Royal Pharmaceutical Society. With regard to delegated prescribing, prescribers are reminded that patients remain under the oversight of the prescriber, requiring that the prescriber must be familiar with the patient through an initial face to face consultation and diagnostic assessment of the patient's suitability for treatment. This applies to the routine/planned/repeat administration of medicines that are used specifically for cosmetic purposes, such as botulinum toxins, injected local anaesthetic or topical adrenaline, and the emergency use of medicines such as hyaluronidase. Prescribers are also reminded of their obligation to address the existence of competing interests and to place the needs of the patient first and be transparent about their actions.
Aesthetics in Ireland: the publication of IS EN 16844
Authors: Mcgloin Claudia
Published: September 2019

IS EN 16844 aesthetic medicine services: non-surgical medical procedures has now been published in Ireland. Two years on, what does this mean for Irish nurses and what has changed in Irish aesthetics?
Aesthetic academies
Authors: Senior Amy
Published: September 2019

Over the last decade, non-surgical aesthetics has transformed due to an increase in academies promoting profitable, yet unsupported, certifications. Patient safety and maintaining good practice standards must be at the forefront of mind as the landscape moves forward
The forum for aesthetics education
Authors: Niemier Lisa
Published: September 2019

The largest professional association for aesthetic nurses in the UK, the British Association of Cosmetic Nurses is an invaluable group that promotes top-class standards in aesthetic care
Tactic matters: focus your marketing on client needs
Authors: Ratcliffe Jason
Published: September 2019

Commonly, it can be tempting to market a product or service to as wide an audience as possible. Going back to basics, this article will suggest re-thinking marketing tactics and remembering what a product is really for: helping someone
Embracing the Cascade: evidence-based medicine
Authors: Redpath Adam , Bowen Mark
Published: September 2019

The prescribing cascade is a risk-based algorithm that is applied on a case-by-case basis when selecting medicines that are not authorised in a given clinical scenario. It allows for the use of other veterinary medicines, whether authorised in the horse or other species, the use of human medicines from the UK and veterinary medicines from the EU or the use of specials (compounded or medicines produced extemporaneously). Its application brings with it several professional obligations and responsibilities, including the need to obtain written consent. Given the potential food-producing status of the horse, equine veterinary surgeons have additional considerations compared to those working with other species (whether farm animal or companion). Medicine selection under the Cascade must be based on valid justifications for not using authorised medicines (where available) and for the selection of subsequent steps in the Cascade. These justifications should be based on clinical need and a robust evidence base. Given that the Cascade exists to improve animal welfare, cost should not normally be considered as a reason for selecting medicines in the horse.
An overview of proximal suspensory ligament desmitis
Authors: Anderson Jonathan
Published: September 2019

Proximal suspensory disease is a common cause of both forelimb and hindlimb lameness and poor performance in the horse. The following article describes the common presentations, diagnostic techniques and treatment options for the condition in both the forelimbs and the hindlimbs.
Diseño y evaluación de cosméticos con vinagre y extracto de manzana
Authors: Sánchez Cueto María , Zarzuelo Castañeda Aránzazu
Published: September 2019

El vinagre de manzana está compuesto en gran parte por compuestos polifenólicos que le confieren una serie de características óptimas para el cuidado de la piel, entre las que se encuentran la actividad antioxidante, antimelanogénica, anticelulítica, seborreguladora o antiinflamatoria; dichas propiedades están acentuadas en el extracto de manzana ya que posee un perfil fenólico superior.Se realizaron cuatro formulaciones cosméticas (dos cremas antiarrugas, un cremigel seborregulador y un gel anticelulítico) añadiendo el vinagre o el extracto, dependiendo del efecto y cosmeticidad buscada, a una base previamente seleccionada y elaborada mediante las técnicas de emulsificación o gelificación.Los resultados de los estudios de estabilidad combinada concluyente, óptimos para las cuatro formulaciones, permitieron fijar una caducidad de 24 meses, lo que hace factible su elaboración y distribución a nivel comercial.En base a todos los estudios realizados se puede concluir que la incorporación del vinagre o extracto de manzana en fórmulas cosméticas es una opción a tener en cuenta, ya que aporta múltiples beneficios para la piel, no presenta problemas de incorporación a las bases y por su bajo coste no encarece sustancialmente la fórmula final.
Uso de análogos de somatostatina en las angiodisplasias gastrointestinales refractarias a otros tratamientos
Authors: Villa Del Bosque Gerardo , Álvarez Núñez Noemí , Domínguez Carbajo Ana Belén , Ortega Valín Luis
Published: September 2019

La malformación vascular más común del tracto digestivo son las angiodisplasias gastrointestinales. Se caracterizan por una dilatación venocapilar con elevada fragilidad vascular, estado patológico que deriva en sangrados gastrointestinales. La prevalencia aumenta en pacientes de edad avanzada y pluripatológicos, lo que condiciona el tratamiento y pronóstico de las angiodisplasias.El objetivo es evaluar la eficacia del tratamiento de las angiodisplasias con análogos de somatostatina, siendo estos el Octreótido y el Lanreótido (fuera de ficha técnica para la indicación), en condiciones de práctica clínica habitual. Además, se tratará de relacionar la respuesta terapéutica con la localización de las lesiones, comorbilidades, reingresos, transfusiones sanguíneas y prescripción de anticoagulantes.Se llevó a cabo un estudio observacional retrospectivo con datos obtenidos de pacientes tratados en el Complejo Asistencial Universitario de León. Tras el análisis estadístico de los datos, se concluyó que no existen diferencias significativas entre los fármacos. Tampoco se encontró asociación significativa del éxito con las localizaciones de las angiodisplasias, ni con las comorbilidades coexistentes, ni con la toma de anticoagulantes. Sólo tratamientos de larga duración (> 11 meses) se relacionan con indicadores objetivos de éxito, como la reducción del número de transfusiones y de reingresos.
Labour: Can we make it a better experience?
Enhancing knowledge, expectations and use of natural pain relief in labour.
Authors: Brijmohan Sharmela , Ramdeholl Dr.H , Pedro Dr.L
Published: September 2019

While a large body of research has explored risk factors for poor birth outcomes and catastrophic birth events, less attention has been paid to positive birth experience and maternal satisfaction.

Between 10-20% of all women have negative experience. The reported prevalence of posttraumatic stress disorder after childbirth ranges from 1.5% to 6%

Given the lack of regular use of labour analgesia and poor availability of childbirth education classes in Guyana, it is important patient have positive expectations and adequate knowledge of the labour process and strategies of natural pain relief.

These factors not only impact on the resulting experience, but on the quality of subsequent mothering, attitudes toward modes of future deliveries and on CS rates.
La reinterpretación del descenso de Cristo a los infiernos en los mosaicos litúrgicos del Centro Aletti
Authors: Ruiz de Loizaga Martín María
Published: September 2019

Los programas musivos de carácter litúrgico del Centro Aletti reflejan una fusión entre tradición y contemporaneidad. Entre las fuentes iconográficas procedentes de la tradición, se percibe la influencia del arte bizantino. El estudio de la historia del icono nos permite ahondar en su sentido y comprender su presencia en estos mosaicos. En el presente artículo se analiza la recuperación de la iconografía bizantina, así como de los Padres de la Iglesia, en las obras del Centro Aletti, en especial, en la reinterpretación que su director, Marko Ivan Rupnik, realiza del descenso de Cristo a los infiernos.
«La Iglesia se inclina hacia el hombre y hacia el mundo»: el puesto central del diálogo de Pablo VI en el Concilio Vaticano II
Authors: Zammit Mark Joseph
Published: September 2019

Todo estudio sobre la figura de Pablo VI resulta de gran actualidad, tanto por su enorme influencia en el papa Francisco, como por el sello que su pontificado ha dejado en la Iglesia del presente. En este artículo se investigará el papel que el diálogo desempeñó en su actuación y en su pensamiento, de manera particular durante el desarrollo del concilio. Presentaremos el ambiente en que creció Montini y los momentos más significativos en su vida, es decir, su formación, su labor diplomática y su misión como arzobispo de Milán. Nos fijaremos en algunos momentos del concilio y cómo Pablo VI trató el tema del diálogo en esos momentos, de manera particular nos ocuparemos de la encíclica Ecclesiam suam. Por último, concluiremos el artículo desarrollando cómo se plasma el tema del diálogo en las constituciones conciliares Dei Verbum, Lumen gentium y Gaudium et spes.
La ciudadanía desde el pensamiento social religioso comparado islamocristiano
Authors: Villagrán Gonzalo
Published: September 2019

El concepto de ciudadanía, en cuanto pertenencia a una comunidad política, es un concepto de carácter secular fruto de la modernidad occidental y clave para una sana separación entre la religión y la política. Sin embargo, las tradiciones religiosas pueden ayudar a comprender con más profundidad este concepto. Desde una perspectiva de teología comparada la tradición política secular y las tradiciones cristiana e islámica de pensamiento político tienen mucho que aprender unas de otras. Cristianismo e islam son iluminadas desde la idea secular de ciudadanía para profundizar en la justa diferenciación religión-política. Por su parte, ambas tradiciones religiosas, cada una a su manera, enseñan a la tradición secular a ver a la persona como una unidad que incluya su dimensión religiosa y a ver la ciudadanía como abierta a la realidad de la familia humana.
Eficiência e governança portuária: evidência do sistema portuário brasileiro
Authors: Sousa Erivelto Fioresi de , Filho Adolpho Olimpio dos Santos , Ramos Flavia Bonella Ribeiro , Souza Ricardo Augusto Gomes , Junior Valdir Cardoso
Published: September 2019

Dada a importância dos portos brasileiros para o desenvolvimento da economia nacional, o presente trabalho buscou avaliar a eficiência dos portos brasileiros em função do sistema de governança portuária. Para tal, avaliou-se a eficiência portuária através da Análise Envoltória de Dados (DEA) orientada a insumos. Foram considerados tanto retornos de escala constantes como retornos variáveis. Os resultados apontam que a eficiência portuária, considerando o tempo de espera dos navios para atracação, é reduzida, indicando a necessidade de investimentos tanto em termos estruturais como na relação entre os atores envolvidos nas operações portuárias.
Análise de pontos de aleatoriadade como estratégia para melhoria de ótimos locais em uma heurística construtiva
Authors: Losqui Hugo Vinicius Freitas , Souza Flávio Henrique Batista de
Published: September 2019

Esse artigo tem como objetivo fazer uma análise sobre o algoritmo NN*. Foi proposto um deslocamento no ponto de aleatoriedade de base por meio de duas propostas, a fim de obter uma otimização em relação ao algoritmo NN*. Após alteração, foram obtidos percentuais de ganhos na margem de até 24% sobre os valores da literatura.
Modelagem e simulação de uma proposta de estoque flow rack para otimizar o layout do armazém de medicamentos e reduzir os desperdicíos
Authors: Almeida Matheus das Neves , Melo Antonio José Moreira de , Costa Jonathan Brito , Gama Herika Oliveira
Published: September 2019

Este artigo aplicou técnicas de gestão de estoque e mudança no layout do armazém para a redução de desperdícios de produtos defeituosos, movimentações e processamentos desnecessários em um armazém de uma distribuidora de medicamentos e materiais correlatos. Para tanto, dividiram-se as variáveis do estudo em duas etapas: a primeira diz respeito às dimensões do layout do armazém, as das disposições dos estoques atuais e das dimensões das embalagens dos produtos em estoque; e a segunda refere-se aos dados históricos de vendas como a quantidade vendida e preço de venda dos produtos dos últimos 6 meses. Ademais, utilizou-se os softwares, Allyphama para baixar os dados do histórico de vendas, o Microsoft Excel para gerar planilhas que auxiliassem nos estudos, o AutoCad para gerar as plantas baixas atual e melhorada do armazém e o SolidaWork para modelar e simular a estrutura proposta do estoque flow rack. Como resultado este artigo investigou in loco os desperdícios e constatou que os principais foram: desperdícios de produtos defeituosos (produtos vencidos), de movimentação desnecessária e de processamentos desnecessários. Frente ao constatado, buscou-se melhorar o sistema logístico da empresa com a utilização da modelagem e simulação de uma proposta de estrutura de estoque do tipo flow rack, que obteve uma redução significativa na área utilizada de aproximadamente 35% e consequentemente reduzir os desperdícios supracitados. Dessa forma, conclui-se que a aplicação das técnicas de gestão de estoque e mudança no layout para a redução de desperdícios é de fato benéfica para as organizações e que
Avaliação de implementação lean manufacturing: estudo de caso no setor de manutenção de uma siderúrgica de grande porte
Authors: Mota Júnior Raimundo Cezário
Published: September 2019

O Lean Manufacturing tem se mostrado uma importante ferramenta de gestão para organizações que visam competitividade em um mercado cada vez mais exigente e informado. Este artigo apresenta uma avaliação do grau de implementação da filosofia Lean no setor de manutenção de componentes em uma oficina central, situada em uma usina siderúrgica de grande porte localizada no estado de Minas Gerais. Para alcançar o objetivo deste estudo foram realizadas visitas ao setor e entrevistas semiestruturadas com a equipe que trabalha no programa de implementação da filosofia junto aos funcionários. Anexo as entrevistas foram formulados checklists que avaliaram qualiquantitativamente as ferramentas implementadas gerando dessa maneira um gráfico do grau de implementação das mesmas. Apesar de certo grau de subjetividade inerente ao processo de avaliação qualitativo, é possível identificar no artigo, o atual grau de maturidade da filosofia, destacando forças e fraquezas na implementação, sinalizando assim aspectos que merecem especial atenção no processo de aperfeiçoamento do modelo enxuto.
Geração z e os seus impactos na cultura organizacional
Authors: Saltoratto Gustavo Mello , Gaschler Tamara , Aguiar Virgínia do Socorro Motta , De Oliveira Maria Célia
Published: September 2019

Com a chegada da “Era da Informação”, as empresas passaram a considerar os funcionários como agentes ativos, responsáveis pelo processamento das informações e pela constituição da vantagem competitiva. Entretanto, conflitos surgem no ambiente de trabalho devido às diferenças culturais entre os colaboradores, que pertencem a diferentes gerações. A Geração Z, composta por aqueles nascidos após 1995 e caracterizados por terem crescido com a internet, está ingressando no mercado de trabalho atual, e por possuir características próprias, provavelmente haverá um incremento das diferenças culturais entre as gerações. Com o objetivo de analisar o perfil da Geração Z, foi realizado um estudo de caráter descritivo, de natureza quali-quantitativa, com 76 alunos de um curso de Engenharia de Produção de uma universidade privada da cidade de São Paulo, a fim de verificar quais são as características desta geração e o tipo de mudança que a mesma poderá promover na cultura das organizações. Com os resultados obtidos, foi possível descrever a geração com maior assertividade e também fomentar um cenário sobre seus integrantes como futuros líderes das organizações.
A logística reversa no setor farmacêutico
Authors: Stocher Francielli Moreira , Da Silva Mygre Lopes , Cappellari Gabriela , Cassanego Junior Paulo Vanderlei
Published: September 2019

Este trabalho tem como objetivo analisar de que forma a logística reversa atua no descarte dos resíduos de duas redes farmacêuticas localizadas na cidade de Santana do Livramento, RS. O embasamento teórico discute a definição de logística, logística reversa, a indústria farmacêutica, o descarte de resíduos farmacêuticos e seus efeitos no meio ambiente. Para tal, emprega-se um estudo de multicasos, por meio de uma pesquisa qualitativa, com dados coletados por entrevistas estruturadas com farmacêuticas das redes Panvel e Preço Mais Popular. A análise dos dados é realizada por meio da análise de conteúdo e a agregação em mapas conceituais. Os resultados apontam que ambas terceirizam o recolhimento e tratamento dos medicamentos, o qual ocorre em outras regiões. Contudo, apenas a rede Panvel possui ponto de coleta, o qual influencia na atração de clientes, tornando-se um diferencial competitivo.
Long Term Alteration of Immune Functions Following Low Level Exposure to Sarin in Rats
Authors: Kassa Jiří , Kročová Zuzana , Vachek Josef
Published: September 2019

1. Long term alteration of immune functions caused by low doses of nerve agent sarin were studied in rats exposed to sarin by inhalation. The alteration of immune functions by sarin was monitored by using two methods (the evaluation of in vitro spontaneous as well as stimulated proliferation of spleen cells and in vitro bactericidal activity of peritoneal macrophages) at 3, 6 and 12 months following sarin exposure. 2. The results indicate that not only symptomatic but also asymptomatic dose of sarin is able to alter some immune functions at six and twelve months following exposure to sarin. 3. Thus, not only organophosphorus insecticides but also nerve agents such as sarin can be potentially immunotoxic even at very low doses that do not cause clinically manifested intoxication following the inhalation exposure. The ability of sarin at low doses to alter immune functions seems to be really long term (up to 12 months following the exposure).
Comparison Between Blood and Crystalloid Cardioplegia in Patients with Left Ventricular Dysfunction Undergoing Coronary Surgery
Authors: Brát Radim , Tošovský Jan , Januška Jaroslav , Derych Leo , Velkoborský Svatopluk , Bruk Vilém , Dominik Jan
Published: September 2019

This study was done to compare the protective effect of blood and crystalloid cardioplegia in patients with left ventricular dysfunction undergoing coronary artery bypass grafting (CABG). Sixty consecutive patients with left ventricular ejection fraction < 35 % scheduled for CABG with the use of cardiopulmonary bypass without additional procedures were randomly divided into two groups. In the first group we used cold blood cardioplegia, in the second group cold crystalloid cardioplegia, both delivered only ortogradly. We measured hemodynamic data in early hours after operation, enzyme release and we collected other clinical data which could be influenced by perioperative myocardial protection. There was no death in either group. We also didn’t find any significant difference in incidence of perioperative myocardial infarction, arrhytmias and use of intraaortic balloon pumping between both groups. In an early hours after operation in the group with blood cardioplegia we found significantly better hemodynamic data (LVSWI, RVSWI) and significantly lower enzyme release. We conclude, that cold blood cardioplegia shows superior perioperative myocardial protection resulting in earlier restoration of myocardial function. This difference could be important in patients with high degree of left ventricular dysfunction.
Neandertalczyk i człowiek anatomicznie współczesny w ujęciu najnowszych źródeł archeologicznych i paleoantropologicznych
Authors: Dec Olga
Published: September 2019

The article summarises recent discoveries regarding Neandertals and anatomically modern humans (AMH), and tries to examine currently leading trends in the fields of archaeology and palaeoanthropology. Collected evidence suggests that modern research focuses mostly on discussions on the origin of symbolism, cultural and cognitive capacities, and analyses of ancient DNA. Although archaeology and palaeoanthropology undoubtedly provide the highest number of sources, other sciences such as cognitive neuroscience also deliver new, equally valuable perspectives and information.
Na tropie szamanizmu w paleolicie – na przykładzie jaskiń Cougnac i Pech-Merle .
Authors: Górzyński Michał
Published: September 2019

The author of this thesis searches for traces of shamanism in paleolithic period through identification of signs and anthropomorphic resemblances that can have a connection with different stages of trance and shamanistic visions. For this article, Pech-Merle and Cougnac cave were chosen. Chronological range in this paper covers a period when Gravettian and Magdalenian cultures functioned. In order to carry out the above assumptions, the author used the results of structuralist research- search- ing for deep meaning and symbols, neuropsychological research – influence of altered states of con- sciousness on human and role of rites in simple societies, ethnographic research- different types of shamanic vocation and visions of shamanistic cosmology as well as interpretation of paintings and engravings based on the above mentioned scientific instruments. In the conclusion, the author shows that magical and religious practices similar to shamanism could function in paleolithic hunter-gatherer societies.
Studnia – szczególny obiekt w przestrzeni stanowiska archeologicznego. Wprowadzenie do problematyki badawczej
Authors: Piotrowska Magdalena , Michałowski Andrzej
Published: September 2019

A significant increase in the amount of materials obtained from the recent large area excavations resulted in numerous finds of wells. For years, these unique archaeological features were not treated as a separate research problem. In order to obtain the fullest research results, an increasing interdisciplinarity involving different fields of science is applied to the studies on wells nowadays. Constructions made of organic raw materials are extremely rare in the space of a typical archaeological site and they are also extremely important sources for gaining knowledge about particular settlements. Wells are accompanied by a certain range of features related to the use of water intake and located in its immediate vicinity. These discoveries allow for extremely interesting interpretations of the functional connections between individual complexes of this type. Functions of wells are an issue that is inextricably linked to the location of such complexes in the settlement’s space. Another aspect related to studies of these features is their extremely rich symbolism. Wells are special archaeological features. Their uniqueness places them among the most interesting objects studied by archaeologists.
Dystrybucja i rola sztyletów krzemiennych wśród społeczności grupy kościańskiej kultury unietyckiej – analiza typologiczno-chronologiczna materiałów z Niziny Wielkopolsko-Kujawskiej oraz studium przypadku znaleziska z Bronikowa (gm. Śmigiel)
Authors: Teska Sebastian , Pyżewicz Katarzyna , Majorek Piotr
Published: September 2019

The article focuses on the matter of significance of flint daggers on the area settled by Early Bronze Age societies connected with Únětice Culture Kościan Group. Analytical part is separated into two sections. The first is a case study of a stray find from Bronikowo (com. Śmigiel) and the second involve typological analysis of flint daggers from western part of Polish Lowlands. Results gathered give an overview of an issue propounded in a title.
Endokanibalizm – rytualny posiłek jako element kultu przodków
Authors: Żychliński Daniel
Published: September 2019

This article presents the hypothesis concerning the practicing of ritual eating of dead bodies of family members by people of Wielbark culture in Wielkopolska (Greater Poland) in the Roman Period. Such practices are called as endocannibalism and this custom is connected very closely with ancestors’ worship. It is an expression of love to a dead family member and an attempt of assimilating his best features. Such a possibility is suggested by archaeological discoveries made at Wielbark culture cemeteries in Wielkopolska (Greater Poland). Endocannibalism was noticed in the past, but is also recorded in modern times.
Fractional Powers of Monotone Operators in Hilbert Spaces
Authors: Hauer Daniel , He Yuhan , Liu Dehui
Published: September 2019

The aim of this article is to provide a functional analytical framework for defining thefractional powersAs{A^{s}}for-1<s<1{-1<s<1}of maximal monotone (possibly multivalued and nonlinear) operatorsAin Hilbert spaces. We investigate the semigroup{e-As⁢t}t≥0{\{e^{-A^{s}t}\}_{t\geq 0}}generated by-As{-A^{s}}, prove comparison principles and interpolations properties of{e-As⁢t}t≥0{\{e^{-A^{s}t}\}_{t\geq 0}}in Lebesgue and Orlicz spaces. We give sufficient conditions implying thatAs{A^{s}}has a sub-differential structure. These results extend earlier ones obtained in the cases=1/2{s=1/2}for maximal monotone operators [H. Brézis, Équations d’évolution du second ordre associées à des opérateurs monotones, Israel J. Math. 12 1972, 51–60], [V. Barbu, A class of boundary problems for second order abstract differential equations, J. Fac. Sci. Univ. Tokyo Sect. IA Math. 19 1972, 295–319], [V. Barbu, Nonlinear Semigroups and Differential Equations in Banach Spaces, Noordhoff International, Leiden, 1976], [E. I. Poffald and S. Reich, An incomplete Cauchy problem, J. Math. Anal. Appl. 113 1986, 2, 514–543], and the recent advances for linear operatorsAobtained in [L. Caffarelli and L. Silvestre, An extension problem related to the fractional Laplacian, Comm. Partial Differential Equations 32 2007, 7–9, 1245–1260], [P. R. Stinga and J. L. Torrea, Extension problem and Harnack’s inequality for some fractional operators, Comm. Partial Differential Equations 35 2010, 11, 2092–2122].
Measuring lower limb circumference and volume – introduction of a novel optical 3D volumetric measurement system
Authors: Tischer Thomas , Oye Sebastian , Wolf Andreas , Feldhege Frank , Jacksteit Robert , Mittelmeier Wolfram , Bader Rainer , Mau-Moeller Anett
Published: September 2019

This study comprised two experiments: (1) the reliability of a novel optical three-dimensional (3D) volumetric measurement system (BODYTRONIC® 600) for the assessment of lower limb circumference and volume; (2) the comparison of data obtained from BODYTRONIC® 600 with that provided by computed tomography (CT) for accuracy estimation. Reliability was assessed in 20 healthy subjects. Accuracy was determined by comparing the deviations in the surface topology of two 3D models obtained from BODYTRONIC® 600 and CT. Reliability was very high for leg circumference measures [coefficient of variations (CVs) range 0.3%–1.3%] and slightly lower for foot circumference (CVs around 2.0%). Reliability of leg volume was also found to be very high (CVs ≤ 2.5%). Differences in surface topology between BODYTRONIC® 600 and CT were primarily below 1 mm indicating high accuracy. The volumes of the foot were higher (range 0.9%–1.7%) and that of the leg, lower (range 1.0%–1.3%) compared to CT. The BODYTRONIC® 600 system provides fast, highly reliable and accurate measures of lower limb circumference and volume and can be considered as a valuable measurement tool for use in various research and clinical applications.
Optimization of microwave-assisted manganese leaching from electrolyte manganese residue
Authors: Chang Jun , Srinivasakannan Chandrasekar , Sun Xianxiu , Jia Fukang
Published: September 2019

The process optimization of microwave assisted leaching of manganese from electrolytic manganese residue (EMR) was conducted. The Box-Behnken design (BBD) was utilized to determine the number of experiments as well as to assess the effect of the main leaching parameters, including the reaction temperature, reaction time, concentration of sulfuric acid and dosage of citric acid. A quadratic model was found to best fit the experimental data and was utilized to optimize the process parameters to maximize the percentage manganese recovery. 3-D response surface plots and contour plots were generated utilizing mathematical models to understand the effect of variables as well as to identify the optimal conditions. The optimum conditions of microwave assisted leaching were: temperature of 76°C, time of 55 min, H2SO4 concentration of 0.76 mol·L-1, dosage of citric acid of 3.51 mg/g. Under these conditions, the percentage manganese recovery higher than 90% could be achieved.
Urban Autonomy in South African Intergovernmental Relations Jurisprudence
Authors: Pieterse Marius
Published: September 2019

The notion of urban autonomy is increasingly significant in a global era where city governments are playing an ever-growing role in development, as well as in domestic and international politics. While extending significantly beyond legal configurations of local government powers and functions, urban autonomy is importantly shaped, enabled and protected by constitutional and legal provisions. This is so especially where urban governance happens in a resource-strapped and often politically volatile environment. This article considers the extent to which formal constitutional structures, and their justiciability, enable and channel urban autonomy in the developing world, with a focus on the constitutionally ensconced powers and functional authority of cities in South Africa. Through an overview of relevant constitutional and statutory provisions and of court decisions upholding urban autonomy in intergovernmental disputes, the article illustrates that South African cities have been served well by a constitutional framework emphasising cooperative governance and developmental local government, as well as by the justiciable entrenchment of local government’s executive, legislative and administrative authority.
Crystal structure of bis(acridin-10-ium) 2,5-dihydroxyterephthalate — 2,5-dihydroxyterephthalic acid (1/1), C21H15NO6
Authors: Chang Xin-Hong
Published: September 2019

C21H15NO6, triclinic, P1̄ (no. 2), a = 9.3591(4) Å, b = 9.4371(5) Å, c = 10.1106(5) Å, α = 102.581(4)°, β = 92.929(4)°, γ = 102.573(4)°, V = 846.09(7) Å3, Z = 2, R
gt(F) = 0.0452, wR
ref(F
2) = 0.1135, T = 288.7(3) K.
An essay on periodic tables
Authors: Pyykkö Pekka
Published: September 2019

After a compact history of the PT, from Döbereiner’s triads to the theoretical predictions up to element 172, a number of particular issues is discussed: Why may Z = 172 be a limit for stable electron shells? What are the expected stability limits of the nuclear isotopes? When are formally empty atomic orbitals used in molecular electronic structures? What is ‘Secondary Periodicity’? When do the elements (Ir, Pt, Au), at the end of a bond, simulate (N, O, I), respectively? Some new suggestions for alternative PTs are commented upon. As a local connection, Johan Gadolin’s 1794 analysis of the Ytterby mineral is mentioned.
Introduction
Authors: Dinter Martin T. , Reitz-Joosse Bettina
Published: September 2019

This introduction outlines the meaning of ‘intermediality’, both with respect to the prefix ‘inter’, which does not only hint at interactions ‘between’ media but also at commentary about and phenomena within media, as well as to the concept of ‘media(lity)’. In so doing, it explains and critiques, for those new to intermedial analysis, the major schools of thought which define this field, drawing on Rajewsky, Elleström, Bruhn, Wolf, and their peers. It also demonstrates why intermediality is a useful framework for Classics research using Roman comedy as a case study, and contains chapter summaries for the special issue as a whole.
Quotations in Roman Prose as Intermedial Phenomena
Authors: Tischer Ute
Published: September 2019

This article takes as its starting point the observation that quotations in Latin prose are largely characterised by features of oral communication. It analyses four passages from Cicero, Suetonius, Gellius, and Servius so as to outline how these quotations bridge the verbal and the written, and can therefore be classified as covert intermedial representations. Specific formulae which shape text passages as quotations include both explicit markers such as ferunt (‘they say’) and dixit (‘he said’), as well as implicit hints ranging from demonstrative pronouns (illud, haec) to conjunctions (ut, sicut). These linguistic tags are read within the frameworks of ‘intermedial reference’ and ‘remediation’, thereby yielding insights on how oral and written features meld into the literary quotations of Roman prose. What is more, this chapter demonstrates the merits of its approach to Classical literature by showing that an awareness of media and medialities is conducive to original interpretations of well-studied ancient texts.