bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Circulating Tumor Cells and Circulating Free DNA from Peripheral Blood in the Prognosis of Advanced Gastric Cancer
Authors: Yu Pengjie , Zhu Shengmao , Luo Yushuang , Li Ganggang , Pu Yongqiang , Cai Baojia , Zhang Chengwu
Published: January 2022

Objective. To explore the application value of circulating tumor cells (CTCs) and circulating free DNA (cfDNA) from peripheral blood in the prognosis of advanced gastric cancer (AGC). Here, we measured CTCs and cfDNA quantity for predicting the outcome of patients. Patients and Methods. Forty-five patients with advanced gastric cancer who underwent neoadjuvant chemotherapy and surgical treatment were enrolled in this study. All patients received neoadjuvant chemotherapy with paclitaxel + S-1 + oxaliplatin (PSOX) regimen, and CTCs and cfDNA of the peripheral blood were detected before and after neoadjuvant therapy. Relationships between the number/type of CTC or cfDNA and the efficacy of neoadjuvant chemotherapy were analyzed. Results. Among 45 patients, 43 (95.6%) were positive, and the positive rate of mesenchymal CTC was increased with the increase in the T stage. The proportion of mesenchymal CTC was positively correlated with the N stage (

P
<
0.05

), and the larger N stage will have the higher proportion of mesenchymal CTC. Patients with a small number of mesenchymal CTC before neoadjuvant chemotherapy were more likely to achieve partial response (PR) with neoadjuvant therapy. Patients with positive CA-199 were more likely to achieve PR with neoadjuvant therapy (

P
<
0.05

). Patients in the PR group were more likely to have decreased/unchanged cfDNA concentration after neoadjuvant therapy (

P
=
0.119

). After neoadjuvant therapy (before surgery), the cfDNA concentration was higher and the efficacy of neoadjuvant therapy (SD or PD) was lower (

P
=
0.045

). Conclusions. Peripheral blood CTC, especially interstitial CTC and cfDNA, has a certain value in predicting the efficacy and prognosis of neoadjuvant chemotherapy in advanced gastric cancer.
Abstract IA-37: Addressing cancer health disparities among Indigenous communities
Authors: Caron Nadine R. , Garvey Gail , Scott Nina , Clarmont Warren , Linn Kevin
Published: January 2022

Many Indigenous Peoples around the world continue to experience substantial inequities in health as a result of the enduring legacy of colonisation, marginalization and disempowerment. While there are many thousands of miles that separate our presenters by distance, we are united in our conviction to work collaboratively to improve the health and wellbeing of Indigenous peoples and to honor the cultural diversity and strengths within our communities with whom we are fortunate to work alongside. Providing global, national and regional perspectives from New Zealand, Australia and Canada, this presentation will capture both the common strengths and shared challenges faced by Indigenous Peoples within the realm of health, wellness, and cancer. Harnessing learnings and reflections from previous World Indigenous Cancer Conferences (WICCs), and the presenters research activities, they will discuss the challenges and solutions to improve cancer surveillance, strengthening our ability to develop and monitor cancer control plans with a focus on improving equity in cancer outcomes. This session directly responds to the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP) and Indigenous People's rights to self-determination.

Citation Format: Nadine R. Caron, Gail Garvey, Nina Scott, Warren Clarmont, Kevin Linn. Addressing cancer health disparities among Indigenous communities [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-37.
Abstract PO-004: Hot spot analysis of cervical cancer among racial and ethnic minorities in Los Angeles County
Authors: Martinez Bibiana M. , Thompson Laura , Cockburn Myles , Tsui Jennifer
Published: January 2022

Background: Geospatial analysis of cervical cancer cases traditionally combines all racial and ethnic subgroups when examining patterns of disease distribution. Given the diverse populations of Los Angeles County (LAC), there are likely distinct barriers as well as linguistic needs of cancer preventive care unique to high risk populations. We compared the distribution of clusters of cervical cancer disease for Latinas, African Americans, and Asian Americans/Pacific Islanders (AAPI), the three largest racial/ethnic minority groups in LAC. Methods: We included data for all stages of cervical cancer (only malignant tumors) diagnosed from 2000 to 2018 in LAC separately for Latinas, African Americans, and AAPI from the Los Angeles County Cancer Surveillance Program. Hot spot analyses were performed using the Getis-Ord GI*statistic in ArcGIS to compare the distribution of statistically significant clusters of cervical cancer cases in LAC using a fixed band. Hot and cold spots with less than 11 cases were suppressed to protect patient confidentiality. Results: Results show that the pattern of cervical cancer clustering across racial/ethnic categories varies substantially across LAC. Among Latinas (N=4303), data show hot spots in Central and Eastern Los Angeles as well as the San Fernando Valley; hot spots exist in Hollywood, Mid-City, the South Bay, the San Gabriel foothills, and the Eastern suburbs of Los Angeles for Asians/Pacific Islanders (N=1332); and hot spots emerged in Central and South Los Angeles, Long Beach and Alhambra for African Americans (N=770). Cervical cancer hot spots do not fully coincide with the residential distribution of racial/ethnic groups in LAC based on data from the 5-year American Community Survey (2014-2018), particularly among Latinas. Discussion: Given the marked differences in cervical cancer disease clustering across racial and ethnic populations in LAC, hot spot analyses of these groups should be performed separately. Using appropriate methodologies for modeling the geospatial distribution of cervical cancer has important implications for the effective planning, location, and delivery of culturally and linguistically appropriate vaccination and screening interventions to address the diverse cervical cancer prevention needs of different communities in LAC.

Citation Format: Bibiana M. Martinez, Laura Thompson, Myles Cockburn, Jennifer Tsui. Hot spot analysis of cervical cancer among racial and ethnic minorities in Los Angeles County [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-004.
Abstract PO-026: University of Arizona partnership for Native American Cancer Prevention (NACP), outreach core
Authors: Leist Keyauni , Slowtalker Jacquanette
Published: January 2022

Cancer among American Indian/Alaska Native (AI/AN) communities is the second leading cause of death. The Partnership for Native American Cancer Prevention (NACP) was established to addresses cancer health disparities in Native Americans. The Outreach Core of NACP ensures research and tribal community engagement are undertaken in a respectful and inclusive manner with tribal communities. The University of Arizona (UA) Outreach Core: (1) developed (& distributed to 22 Arizona tribal communities) information materials focused on proper tribal consultation and engagement, foundational cancer information including statistics on leading causes of cancers, considerations for cancer survivors and caregivers over the continuum of cancer care including palliative/hospice care and clinical trials. (2) Hosts an Indigenous Cancer Prevention webinar series to showcase successful community-led cancer control initiatives in Indian Country. (3) In collaboration with the UA Responsible Conduct of Research (RCR) Program, offer training in Tribal Consultation & Engagement with Native Communities. (4) Partnered to develop a well-women video to promote preventative cancer screening of Native American women. As part of the Indigenous Cancer Prevention webinar series, a total of seven speakers have presented on various Native American-focused cancer initiatives including: understanding pediatric acute lymphoblastic leukemia, initiatives to address cancer burden; human papillomavirus and cervical cancer; quality of life among cancer survivors and survivorship issues; cancer among Alaska Natives; and cancer trends in Indian Country. Both the webinar series and the UA RCR training have been well received and pre- and post-tests and evaluations demonstrate an increase in knowledge and positive review of content and delivery. The webinar series has reached over 200 attendees of students, service providers, community members, and faculty across half of the United States.

Citation Format: Keyauni Leist, Jacquanette Slowtalker. University of Arizona partnership for Native American Cancer Prevention (NACP), outreach core [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-026.
Abstract PO-055: HPV knowledge, screening barriers and facilitators, and sources of health information among women living with HIV: Perspectives from the DC community
Authors: Ciceron Annie Coriolan , Jeon Min (Jaime) Jeong , Clausen Michelle Elise , Monroe Anne Kress , Magnus Manya , Le Daisy
Published: January 2022

Background: High-risk human papillomavirus (HPV) causes 99% of cervical cancer cases. Despite available prevention methods through the HPV vaccine and two screening modalities, women continue to die from cervical cancer worldwide. Cervical cancer is preventable, yet affects a great number of women living with HIV (WLH). Low screening rates among WLH further exasperates their already high risk of developing cervical cancer due to immunosuppression. Purpose: This study explores WLH's current cervical cancer knowledge, screening barriers and facilitators, and sources of health information. Methods: Focus group discussions were conducted with 39 WLH aged 21 years old or older, who resided in the Washington-Baltimore Metropolitan Area. Emergent themes were classified and organized into overarching domains and assembled with representative quotations. Results: The women had limited knowledge of HPV and the cervical cancer screening guidelines for WLH. Screening barriers also included decreased accessibility to cervical cancer screenings, a novel issue caused by the Coronavirus 2019 (COVID-19) pandemic. Screening facilitators included knowing someone diagnosed with cervical cancer and provider recommendations. WLH indicated that they obtained health information through in-person education (providers, peer groups) and written literature. Due to the pandemic, they also had to increasingly rely on remote and technology-based communication channels such as the internet, social media, television, radio, email, and SMS text messaging. Conclusions: Future health interventions need to explore the possibility of sharing messages and increasing cervical cancer and HPV knowledge of WLH through the use of SMS and other technology-based channels.

Citation Format: Annie Coriolan Ciceron, Min (Jaime) Jeong Jeon, Michelle Elise Clausen, Anne Kress Monroe, Manya Magnus, Daisy Le. HPV knowledge, screening barriers and facilitators, and sources of health information among women living with HIV: Perspectives from the DC community [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-055.
Abstract PO-058: Increasing liver cancer prevention knowledge through a community-based education initiative to improve liver cancer prevention for underserved African, Asian, and Hispanic communities
Authors: Lu Wenyue , Zhu Lin , Ibrahim Safa , Traub Kerry , Kim Ellen , Wong Ada , Rubio-Torio Nathaly , Gonzalez Evelyn , Fraser Marilyn A. , Yeh Ming-Chin , Ma Grace X. , Ogunwobi Olorunseun O. , Tan Yin
Published: January 2022

Background: Though a largely preventable disease, liver cancer is now the fastest-increasing cause of cancer death in the US, and it is highly fatal. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and it disproportionally affect racial/ethnic minorities, especially the medically underserved. Most HCC cases are associated with hepatitis B virus (HBV) and hepatitis C virus (HCV). Methods: To increase awareness of liver cancer prevention and screening, we partnered with community-based organizations through NCI funded U54 TUFCCC/HC Cancer Partnership Community Outreach Core, in the greater Philadelphia metropolitan and New York City to design and conduct a liver cancer prevention project. Pre- and post- survey data was collected from underserved Asian, African, and Hispanic American community members who participated in educational workshops. This abstract will report the 473 eligible participants' knowledge on HBV, HCV, and liver cancer both before and after the education. We conducted wilcoxon Signed-rank, Kruskal-Wallis, and Wilcoxon sum-rank tests. Results: Knowledge of risk factors increased significantly in all three communities from the pre-survey to the post-intervention survey (2.15 vs. 3.69, p<0.0001). Knowledge of risk factors also significantly increased within the African (1.11, p<0.0001), Asian (1.88, p<0.0001) and Hispanic (3.21, p<0.0001) American Communities. There were no significant differences in increased knowledge by gender (male= 2.18 vs female=2.25, p=0.72). Conclusions: The findings of our study show the importance and effectiveness educational interventions have on promoting liver cancer prevention knowledge among the minority groups who are most affected in the U.S. by liver cancer disparity.

Citation Format: Wenyue Lu, Lin Zhu, Safa Ibrahim, Kerry Traub, Ellen Kim, Ada Wong, Nathaly Rubio-Torio, Evelyn Gonzalez, Marilyn A. Fraser, Ming-Chin Yeh, Grace X. Ma, Olorunseun O. Ogunwobi, Yin Tan. Increasing liver cancer prevention knowledge through a community-based education initiative to improve liver cancer prevention for underserved African, Asian, and Hispanic communities [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-058.
Abstract PO-070: Psychometric properties and analysis of the masculinity barriers to medical care scale among African American, Indigenous, and White men
Authors: Brooks Ellen , Figueroa Roger , Petersen Ethan , Campanelli Pamela , Kennedy Carson , Thorpe Roland J. , Levant Ronald F. , Rogers Charles R.
Published: January 2022

Background: The Masculinity Barriers to Medical Care (MBMC) scale was developed to assess masculinity barriers to medical care relative to colorectal cancer (CRC) screening uptake among non-Hispanic (NH) African-American/Black men. Objective: This study aimed to assess the psychometric properties of the MBMC Scale while applying it to different racial groups. Methods: Participants self-identifying as non-Hispanic (NH) Black, American Indian/Alaska Native (Indigenous), or NH White completed the web-based Masculinity Barriers to Medical Care, Psychosocial Factors, and CRC Screening Uptake & Intention Survey. We conducted exploratory factor analysis on a sample of 254 men and multivariate analysis of variance (MANOVA) on a separate sample of 637 men nationally representative by age and state of residence. Results: After assessment of psychometric properties, the MBMC scale was reduced from 24 to 18 items and from six to four subscales. Black men's mean scores were lowest on three of four subscales (Being Strong, Negative and Positive Attitudes) and highest on the Acknowledging Emotions subscale. Compared with both Indigenous and White men, Black men had significantly lower Negative Attitudes subscale scores and significantly higher scores on the Acknowledging Emotions subscale. Compared with both Indigenous and Black men, White men had significantly higher Being Strong and Positive Attitudes subscales scores. Conclusions: This study expands on previous research indicating that, among racialized populations of men, endorsement of traditional masculine ideologies influences engagement in preventive health behaviors. Our scale can be tailored to assess attitudes to screening for other cancers and diseases that disproportionately burden medically underserved populations.

Citation Format: Ellen Brooks, Roger Figueroa, Ethan Petersen, Pamela Campanelli, Carson Kennedy, Roland J. Thorpe, Jr., Ronald F. Levant, Charles R. Rogers. Psychometric properties and analysis of the masculinity barriers to medical care scale among African American, Indigenous, and White men [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-070.
Abstract PO-077: Access to care as a contributing factor to underlying disparities in Hispanic women with ovarian cancer in the United States
Authors: Schiavo Claudia B. , Armaiz Guillermo
Published: January 2022

In the United States, ovarian cancer accounts for only 3% of all cancers in U.S. women. Ovarian cancer trends in the United States report the highest incidence in non-Hispanic white women with Hispanic women having the second highest incidence. Ovarian cancer disparities are present within the Hispanic population because Hispanic women are more likely to be diagnosed with ovarian cancer, not only at an earlier age than non-Hispanic groups, but also at an earlier stage (I-II). Ovarian cancer has the highest mortality among gynecological malignancies in Hispanics, resulting from various factors including unequal access to screening and treatment disparities, such as adherence to treatment and volume-outcome paradigm. Outcomes are paradoxical among Hispanic women, because while a high proportion are diagnosed younger and at early stages, typically associated with improved survival outcomes, they are more likely to not receive the standard of care, which involves more than providing insurance, access, and the services patients need. Inequitable access to care can lead to noticeable differences in health, especially within the Hispanic community in the United States. Our objective is to define access within a conceptual framework of five dimensions—1) approachability; 2) acceptability; 3) availability and accommodation; 4) affordability; and 5) appropriateness—specifically in relation to ovarian cancer disparities in Hispanic women in the US. Utilizing these dimensions, we summarize available knowledge about how inequitable access to care contributes to the underlying disparities that Hispanic women in the US experience, focusing particularly on social determinants of health, as well as adherence to care and the volume-outcome relationship. The health care system needs to develop innovative strategies to educate and inform the surrounding Hispanic communities Despite the limited data available, we summarize the available literature and propose the application of different strategies to help address the potential—systemic, logistic, and geographic—barriers that affect how Hispanic women with ovarian cancer access health care, in order to implement a health care delivery system that is equitable.

Citation Format: Claudia B. Schiavo, Guillermo Armaiz. Access to care as a contributing factor to underlying disparities in Hispanic women with ovarian cancer in the United States [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-077.
Abstract PO-081: Cancer clinical trial access during the COVID-19 pandemic
Authors: Suresh Ashithkumar Beloor , Dahal Subecha , Gantz Christopher , Lopez AnaMaria
Published: January 2022

Introduction: Cancer clinical trial conduction during the COVID-19 pandemic required a rapid move to virtual engagement to support participant and research team safety. We were faced with the challenge of translating our approach from in-person to virtual engagement for recruitment, enrollment, and delivery of the study intervention. We present our strategies to conduct cancer clinical trials focused on cancer risk reduction during the COVID-19 pandemic. Subject Recruitment: Our multimodal approach utilized online platforms and established approaches like posters, flyers, and collaborating with community health workers to recruit participants. Our virtual engagement strategies include direct outreach to potential participants via email, the electronic medical record (EMR), and social media. Contact via email and the EMR was guided by study-defined eligibility criteria. Social media outreach was through institutional Twitter, Facebook, and video channel accounts. Twitter posts and chats were employed. Enrollment: e-consenting and remote consenting processes were instituted via REDCAP. Delivery of the Educational Risk Reduction Intervention: We also conducted the intervention using the Zoom platform and through a recorded video of the educational risk reduction intervention, which is shared with the participant via REDCAP. Challenges: As documented by others, the greatest challenge to virtual engagement is lack of internet access and lack of digital literacy. These factors have a greater impact on underserved populations, including the elderly, those with low socioeconomic status, those located farther from the cancer center, and racially/ethnically diverse populations. Conclusion: By translating study outreach and processes to virtual engagement, we were able to facilitate clinical trial access across diverse community subgroups and support subject participation in clinical trials during the COVID-19 pandemic.

Citation Format: Ashithkumar Beloor Suresh, Subecha Dahal, Christopher Gantz, AnaMaria Lopez. Cancer clinical trial access during the COVID-19 pandemic [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-081.
Abstract PO-101: CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women
Authors: Abou-Fadel Johnathan , Zhang Jun
Published: January 2022

Breast cancer is the most commonly diagnosed cancer worldwide and remains the second leading cause of cancer death. While breast cancer mortality has steadily declined over the past decades through medical advances, an alarming disparity in breast cancer mortality has emerged between African American women (AAW) and Caucasian American women (CAW); and new evidence suggests more aggressive behavior of triple-negative breast cancer (TNBC) in AAW may contribute to racial differences in tumor biology and mortality. Progesterone (PRG) is capable of exerting its cellular effects through either its classic, non-classic or combined responses through binding to either classic nuclear PRG receptors (nPRs) or non-classic membrane PRG receptors (mPRs), warranting both pathways an equally important status in PRG-mediated signaling. In our previous report, we demonstrated that the CCM signaling complex (CSC) consisting of CCM1, CCM2, and CCM3 proteins can couple both nPRs and mPRs signaling cascades to form a CSC-mPRs-PRG-nPRs (CmPn) signaling network in nPR positive(+) breast cancer cells. In this report, we furthered our research by establishing the CSC-mPRs-PRG (CmP) signaling network in nPR(-) breast cancer cells, demonstrating that a common core mechanism exists, regardless of nPR(+/-) cell type. This is the first report stating that inducible expression patterns exist between CCMs and major mPRs in TNBC cells. Furthermore, we firstly show mPRs in TNBC cells are localized in the nucleus and participate in nucleocytoplasmic shuttling in a coordinately synchronized fashion with CCM proteins under steroid actions, following the same cellular distribution as other well-defined steroid hormone receptors. Finally, for the first time, we deconvoluted the CmP signalosome by using multi-omics approaches, which helped us understand key factors within the CmP network, and identify 21 specific biomarkers with potential clinical applications associated with AAW-TNBC tumorigenesis. These novel biomarkers could have immediate clinical implications to dramatically improve health disparities among AAW-TNBCs.

Citation Format: Johnathan Abou-Fadel, Jun Zhang. CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-101.
Abstract PO-108: Predictors of retention rates in the Active Living After Cancer program at MD Anderson Cancer Center: A comparison of classes during and before COVID-19
Authors: Servino Kendahl , Mitchell Stacy , Lee Che Young , Liao Yue , Basen-Engquist Karen
Published: January 2022

Background: As an overlooked aspect of cancer, survivorship often begs the question of “what's next?” once treatment is complete. Physical activity following treatment has been shown to improve quality of life and decrease rates of recurrence. The MD Anderson Active Living After Cancer Program (ALAC) has recruited over 900 cancer survivors and caregivers since its establishment in 2013. This study seeks to examine how retention rates have changed since the transition to virtual classes due to the COVID-19 pandemic, and whether variables associated with retention differ between in person and virtual classes. Methods: A retrospective study of baseline surveys completed by participants (N=860) through Redcap was conducted, excluding those currently enrolled in ongoing ALAC classes. A chi-square test was performed to determine whether completion rates were significantly different between in person and virtual classes. A bivariate regression model was used to determine whether participant demographics varied between virtual and in person classes, based on insurance status and education level. A logistic regression was performed to investigate whether these factors were predictors of retention in either class. Results: Retention rates significantly differed between virtual (87.91%) and in person classes (77.20%); participants of virtual classes were two times as likely to complete the program compared to their in-person counterparts (P=0.00). Compared to in person classes, uninsured participants comprised a larger proportion of virtual classes, while privately and publicly insured participants comprised a smaller proportion (P=0.014). In both classes, participants who never received a high school diploma or GED constituted the most common education level. Having insurance and completion of some higher education were only weakly associated with retention. Conclusion: Given the success of ALAC since its creation, we are interested in expanding enrollment beyond MD Anderson Cancer Center. This study provides understanding of the benefits and limitations of virtual classes since the rise of COVID-19. Overall, greater retention rates demonstrate the utility of virtual classes. Maintaining a virtual aspect of future ALAC classes, such as a hybrid program, may help improve survivor outreach by identifying potentially overlooked groups.

Citation Format: Kendahl Servino, Stacy Mitchell, Che Young Lee, Yue Liao, Karen Basen-Engquist. Predictors of retention rates in the Active Living After Cancer program at MD Anderson Cancer Center: A comparison of classes during and before COVID-19 [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-108.
Abstract PO-113: Overall survival in ovarian cancer patients seeking care at more than one treatment facility
Authors: Deveaux April , Islam Jessica , Akinyemiju Tomi
Published: January 2022

Purpose: Ovarian cancer is the most lethal gynecological cancer and despite advances in treatment, most patients are diagnosed at an advanced stage with poor prognosis. Black women have a lower 5 year survival than White women when diagnosed at the same stage, and while there are a number of contributing factors, quality of treatment center may play a significant role. Choice in treatment facility may be limited by insurance coverage, availability of high-volume hospitals or specialists, or ability to access high-quality facilities, and it is unclear how a change in treatment facility may impact ovarian cancer survival. Methods: Participant usage files from the National Cancer Database were used to interrogate the characteristics of patients that seek treatment at more than one Commission on Cancer accredited facility in the United States to determine the effect on overall survival. Multivariable Cox regression analysis models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI) to determine risk of mortality for patients receiving all of their first course treatment at one facility vs those receiving first course treatment at more than one facility. The fully-adjusted model was then stratified by race/ethnicity (Non-Hispanic White, Non-Hispanic Black, Hispanic) and by facility type (Community, Comprehensive Community, Academic/Research, Integrative Network). Results: A total of 211,937 women were included in the analysis. Patients were more likely to receive all of their first course treatment at one facility (81%). Patents treated at more than one facility had a 26% increase in ovarian cancer mortality compared with those treated at a single facility (HR: 1.26, 95% CI: 1.24-1.28). When stratified by race, NH-Black patients had the lowest increase in overall survival (HR: 1.08, 95% CI: 1.03-1.14) when compared with NH-White (HR: 1.27, 95% CI: 1.25-1.29) and Hispanic (HR: 1.33, 95% CI: 1.28-1.39) patients. Stratification by facility type showed that among women receiving treatment at more than one facility, those switching to an academic research center had the highest mortality (HR: 1.31, 95% CI: 1.28-1.34). Conclusions: Ovarian cancer patients that received treatment at more than one facility had a higher rate of mortality than those who were treated at a single center. Our findings suggest the need for further investigation into the effects of continuity of care, including how race, facility type, and other socioeconomic factors may modulate those effects.

Citation Format: April Deveaux, Jessica Islam, Tomi Akinyemiju. Overall survival in ovarian cancer patients seeking care at more than one treatment facility [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-113.
Abstract PO-118: Patient and county level determinants of surgical treatment for non-small cell lung cancer: A SEER-Medicare analysis
Authors: Odahowski Cassie Lewis , Alberg Anthony J. , Schootman Mario , Zhang Jiajia , Eberth Jan M.
Published: January 2022

Introduction: Rural lung cancer patients experience worse survival than urban lung cancer patients. Worse survival in early-stage rural lung cancer patients may be due lower utilization of surgical treatment compared to their urban counterparts. We examined patient- and county-level determinants of surgical treatment for non-small cell lung cancer, focusing on rural vs. urban disparities. Methods: Our sample included 63,767 localized and regional NSCLC cases diagnosed between 2003-2011 using SEER-Medicare data. Predictors examined included demographics, clinical characteristics, and county factors (urban versus rural designation, percent of the population ≥65 years old below 100% Federal Poverty Limit, and designation as a Medically Underserved Area). Patient characteristics were nested within counties in multilevel logistic regression models stratified by stage at diagnosis, predicting receipt of surgical treatment. Results: Rural residents were less likely to receive surgical treatment than urban residents (42.0% vs. 46.8%, p<0.01), and black patients were less likely than white patients to receive surgery (32.9% vs. 47.1%, p<0.01). Rurality did not remain a significant factor in the final adjusted model. The final model showed an odds of surgical treatment decreased for every 5% increase in county-level poverty for both local stage (OR=0.83, 95% CI:0.77-0.91) and regional stage (OR=0.84, 95%CI: 0.79-0.90). Other patient factors associated with lower likelihood of surgical treatment included older age, male sex, non-married, dual Medicare/Medicaid enrollment, and more comorbidities. Conclusions: Rurality was not associated with receipt of surgery in the final multilevel model, but patient race and county-level poverty were significantly associated with a lower odds of surgery. Future research is needed to understand the causes of these disparities in surgical treatment of lung cancer to maximize survival for all populations.

Citation Format: Cassie Lewis Odahowski, Anthony J. Alberg, Mario Schootman, Jiajia Zhang, Jan M. Eberth. Patient and county level determinants of surgical treatment for non-small cell lung cancer: A SEER-Medicare analysis [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-118.
Abstract PO-128: Completion of nipple reconstruction in triple-negative breast cancer patients compared to triple-positive breast cancer patients: A single institutional analysis
Authors: Amaya Joshua , Jones Kaitlin , Haddock Nicholas T. , Teotia Sumeet S.
Published: January 2022

Background: Triple-negative (TN) breast cancer is considered to be more aggressive than other subtypes of breast cancer and has a poorer prognosis. It is defined as breast cancer tumors that lack estrogen receptor (ER), progesterone receptor (PR), and HER2 expression and affects 17-20% of women with breast cancer. However, reconstructive outcomes remain to be elucidated when compared to other invasive breast cancer subtypes. The aim of this study is to determine if there is a disparity in completing nipple-areolar reconstruction in breast cancer patients with a triple-negative subtype compared to patients with a triple-positive (TP) subtype. Methods: 107 patients who underwent bilateral non-nipple sparing mastectomies from 2013 to 2017 diagnosed with a TN (n = 54) and TP (n = 53) invasive breast cancer subtype were identified. All 107 patients were seen by two attending surgeons at a single institution. Completion of nipple reconstruction and areolar tattoos, number of days from mastectomy to nipple reconstruction, and areolar tattoos were analyzed. Demographic/clinical variables, including race, age, BMI, smoking, comorbidities, neoadjuvant/adjuvant chemotherapy, hormonal therapy, radiation therapy, and choice of implants or flaps were also analyzed. Results: There was no significant difference in the proportion of patients who underwent radiation therapy in the TN group than in the TP group (55.56% vs 37.74%, p = 0.0819). Among these two groups, there was no significant difference in the percentage of patients completing nipple reconstruction (TN = 44.44%, TP = 49.06%, p = 0.7001) and acquiring an areolar tattoo (TN = 33.33%, TP = 39.62%, p = 0.5503). The differences in the average duration in days from mastectomy to nipple reconstruction (TN = 505.7, TP = 456.4, p = 0.5259) and areolar tattoos (TN = 665.6, TP = 638.5, p = 0.7653) among these two patient populations were also insignificant. Conclusion: TN subtype does not make a significant impact on completing nipple reconstruction when compared to TP patients, another extreme. These results should be considered when counseling TN patients on their reconstructive journey.

Citation Format: Joshua Amaya, Kaitlin Jones, Nicholas T. Haddock, Sumeet S. Teotia. Completion of nipple reconstruction in triple-negative breast cancer patients compared to triple-positive breast cancer patients: A single institutional analysis [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-128.
Abstract PO-135: The effects of DCLK1 isoform 2 upon the migration and invasion capabilities of colorectal cancer cells
Authors: Brown Valeria , Li Lianna
Published: January 2022

Double Cortin-like Kinase 1 (DCLK1) is a cancer stem cell (CSC) marker that is over-expressed in CSCs and epithelial-mesenchymal transition (EMT) cells of many cancers. Due to its expression in the chemoresistant, tumorigenic subpopulation in cancer tissue, DCLK1 plays critical roles in indefinite cell proliferation, tumorigenesis, tumor metastasis, and recurrence of cancer. Further evidence has shown that the deregulation or inhibition of DCLK1 directly causes a decrease in cancer succession and reduces the possibility of relapse. DCLK1 has five isoforms and association of each isoform with human colorectal cancer (hCRC) is unclear. For the current project, we aim to reveal correlation of the DCLK1 isoform 2 (DCLK1-S) with invasion and migration capability of hCRC cells. In order to achieve our goal, we established the isogenic DCLK1-S over-expression cells using the HCT116 cell line, performed the scratching assay, and used ImageJ software to determine the wound healing speed of DCLK1-S over-expression cells and HCT116 cells. Our preliminary results demonstrated that DCLK1-S was not associated with increased migration and invasion capability of hCRC cells. Compared to the HCT116 cells, the wound healing speed of DCLK1-S over-expression cells significantly decreased (P<0.05). Therefore, the DCLK1-S might not change migration and invasion capabilities of hCRC cells. In the future, we will further confirm our findings and will determine whether DCLK1-S affect stemness of hCRC CSCs and EMTs from other aspects.

Citation Format: Valeria Brown, Lianna Li. The effects of DCLK1 isoform 2 upon the migration and invasion capabilities of colorectal cancer cells [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-135.
Abstract PO-144: Functional characterization of estrogen-regulated divergent long noncoding RNAs in estrogen receptor-positive breast cancer
Authors: Ramos Enrique I. , Sanchez-Michael Laura A. , Sedano Melina J. , Yang Barbara , Choudhari Ramesh , Harrison Alana L. , Gadad Shrikanth S
Published: January 2022

Introduction/background: Recent studies have shown that long noncoding RNAs (lncRNAs) could be potential biomarkers and therapeutic targets in cancer. LncRNAs are significant in regulating transcriptional, post-transcriptional, and epigenetic changes in human development. Previously, we identified ~1900 lncRNAs in breast cancer (BC) using advanced technologies including Global Run-On sequencing (GRO-seq) and subcellular fractionation RNA sequencing (RNAseq); intriguingly, many were transcribed bidirectionally, now referred to as divergent lncRNAs. Currently, little is known about their role in regulating estrogen-dependent signaling in BC. In this study, we have investigated the role of a previously annotated and characterized estrogen-regulated lncRNA known as lncRNA67. Materials and Methods: We used integrated genomics to compute expression across BC molecular subtypes. Single-molecule RNA-FISH (Fluorescence in Situ Hybridization) determined its localization in BC patient samples. The role of lncRNA67 in estrogen receptor-positive (ER+) BC cells was investigated using stably inducible lncRNA overexpressing MCF7 and T47D cell lines. Total-directional RNA-seq was performed to understand its effect on global gene expression profiles. Results: LncRNA67 showed distinct expression patterns across molecular subtypes of BC. RNA-FISH revealed nucleus and cytoplasm localization, indicating one to two copies of mature RNA are present in ER+ BC patient cells. Functional assays with reduced expression showed inhibited growth of BC cells. When lncRNA67 was overexpressed in ER+ BC cells, the result correlates with clinical outcome. Gene Set Enrichment Analysis (GSEA) showed its role in regulating estrogen-dependent transcription. Conclusion: Our molecular analyses suggest lncRNA67 plays a pivotal role in ER-dependent and -independent pathways. Taken together, our results indicate that lncRNAs are an integral component of cancer biology. Acknowledgments: S.S.G. is supported by a First-time Faculty Recruitment Award from the Cancer Prevention and Research Institute of Texas (CPRIT; RR170020). S.S.G. is also supported by a grant from Lizanell and Colbert Coldwell foundation.

Citation Format: Enrique I. Ramos, Laura A. Sanchez-Michael, Melina J. Sedano, Barbara Yang, Ramesh Choudhari, Alana L. Harrison, Shrikanth S Gadad. Functional characterization of estrogen-regulated divergent long noncoding RNAs in estrogen receptor-positive breast cancer [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-144.
Abstract PO-161: A community-based liver cancer education initiative led to healthier dietary and alcohol use behaviors among racial/ethnic minority community members
Authors: Li Tiffany , Lu Wenyue , Zhu Lin , Kim Ellen , Traub Kerry , Zhu Steven , Rubio-Torio Nathaly , Gonzalez Evelyn , Fraser Marilyn A. , Yeh Ming-Chin , Ma Grace X. , Ogunwobi Olorunseun O. , Tan Yin
Published: January 2022

Background: There is an increasing body of literature that suggests a relationship between modifiable dietary behaviors and alcohol use and liver cancer. We designed and implemented a culturally tailored community-based education program to promote liver cancer prevention. Methods: Through NCI funded U54 TUFCCC/HC Cancer Partnership Community Outreach Core program, using CBPR approach, we engaged community-based organizations and community stakeholders serving underserved African, Asian, and Hispanic American communities in the Philadelphia metropolitan area and New York City. The community-based education incorporated in-person and virtual hybrid education workshops to address COVID-19 pandemic barriers. We conducted pre-education surveys and follow-up assessments at 6 months post-education. Participants' dietary behaviors, alcohol use, and sociodemographic characteristics were examined at both time points. Results: 526 participants were recruited including 92 African Americans, 247 Asian Americans, and 187 Hispanic Americans, with an average age of 59. We found that at 6-month follow-up assessment, participants had average decreased intake of red meat (3.148/6 vs. 2.685/6, p < 0.001), and average increased intake of vegetables (4.484/6 vs. 5.044/6, p < 0.001) and fruits (4.327/6 vs. 4.877/6, p < 0.001), compared to their intake at pre-education assessment. Additionally, average change in beer (-0.252) and spirit (-0.905) consumption substantively decreased from pre-intervention to 6-month follow-up assessment. Conclusion: This community-based education showed significant effects in improving healthy dietary behaviors and reducing alcohol intake among community members through CBPR community engagement from the two metropolitan areas. Future efforts are needed to sustain the positive changes in modifiable lifestyle behaviors and liver cancer prevention in these medically underserved communities.

Citation Format: Tiffany Li, Wenyue Lu, Lin Zhu, Ellen Kim, Kerry Traub, Steven Zhu, Nathaly Rubio-Torio, Evelyn Gonzalez, Marilyn A. Fraser, Ming-Chin Yeh, Grace X. Ma, Olorunseun O. Ogunwobi, Yin Tan. A community-based liver cancer education initiative led to healthier dietary and alcohol use behaviors among racial/ethnic minority community members [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-161.