bluuebunny/crossref_metadata_2025 huggingface dataset:
Sodium butyrate has anti-proliferative, pro-differentiating, and immunomodulatory effects in osteosarcoma cells and counteracts the TNFα-induced low-grade inflammation
Authors: Perego Silvia , Sansoni Veronica , Banfi Giuseppe , Lombardi Giovanni
Published: January 2018

Butyrate, an essential factor for colonocytes and regulator in the development of colon cancer, is partially absorbed by the gut. It influences the proliferation and differentiation of several cell types including osteoblasts. We evaluated the effects of different doses of butyrate on differentiation and functionality of osteosarcoma cells in vitro and the expression of a pro-inflammatory phenotype in a normal or inflammatory environment. SaOS-2 osteosarcoma cells were induced to differentiate and contemporarily treated for 24 h, 48 h, or 7 days with sodium butyrate 10−4, 5 × 10−4, or 10−3 M in the presence or absence of tumor necrosis factor alpha (TNFα) 1 ng/mL, a pro-inflammatory stimulus. Despite the mild effects on proliferation and alkaline phosphatase activity, butyrate dose- and time-dependently induced the expression of a differentiated phenotype (RUNX2, COL1A1 gene expression, and osteopontin gene and protein expression). This was associated with a partial inhibition of nuclear factor kappa B (NF-κB) activation and the induction of histone deacetylase 1 expression. The net effect was the expression of an anti-inflammatory phenotype and the increase in the osteoprotegerin-to-receptor activator of nuclear factor kappa-B ligand (RANKL) ratio. Moreover, butyrate, especially at the highest dose, counteracted the effects of the pro-inflammatory stimulus of TNFα 1 ng/mL. Butyrate affects osteosarcoma cell metabolism by anticipating the expression of a differentiated phenotype and by inducing the expression of anti-inflammatory mediators.
Executive Functions and Response to Intervention: Identification of Students Struggling With Reading Comprehension
Authors: Miciak Jeremy , Cirino Paul T. , Ahmed Yusra , Reid Erin , Vaughn Sharon
Published: January 2018

Inadequate responders demonstrate significant risk for learning disabilities. Previous investigations of the cognitive profiles of inadequate and adequate responders have not included measures of executive functions (EFs), which have well-documented associations to reading comprehension. We evaluated EF performance on a common factor comprised of shared variance across tasks as well as five separable EF factors in the context of an intensive reading intervention for struggling fourth graders. To determine whether EF performance at pretest is associated with subsequent responder status, we compared EF performance of three subgroups of students: inadequate and adequate responders and typical students not at risk for reading disabilities. Results of discriminant function analyses and linear regression models comparing groups were largely null; EF performance at pretest demonstrated only small associations with responder status. These results suggest that the assessment of EF may have limited value in predicting which individual students will respond to intensive reading interventions.
Potential Cognitive Benefits From Playing Music Among Cognitively Intact Older Adults: A Scoping Review
Authors: Schneider Catherine E. , Hunter Elizabeth G. , Bardach Shoshana H.
Published: January 2018

The aging population is growing rapidly, raising rates of cognitive impairment, which makes strategies for protection against cognitive impairment increasingly important. There is little evidence indicating highly effective interventions preventing or slowing onset of cognitive impairment. Music playing influences brain and cognitive function, activating multiple brain areas and using cognitive and motor functions as well as multiple sensory systems, simultaneously. The purpose of this study was to review the current evidence related to playing a musical instrument being a potentially protective mechanism against cognitive decline among older adults. Using scoping review procedures, four databases were searched. Paired reviewers analyzed articles for content, design, and bias. Eleven studies met study criteria and were included in the review. All studies showed that music playing was correlated with positive outcomes on cognitive ability; more high-quality research is needed in this area to understand mechanisms behind potential cognitive protection of music.
Intensity of Care at the End of Life Among Older Adults in Korea
Authors: Kim Su Hyun , Kang Sangwook , Song Mi-Kyung
Published: January 2018

Aim:

To examine the intensity of care at the end of life among older adults in Korea and to identify the individual and institutional factors associated with care intensity.

Methods:

This secondary data analysis included a sample of 6278 decedents aged 65 years or older who were identified from the 2009 to 2010 Korean National Health Insurance Service–National Sample Cohort Claims data. We examined the medical care received by the cohort in the last 30 days of their lives.

Results:

Overall, 36.5% of the sample received at least 1 intensive care procedure in the last 30 days of their lives; 26.3% of patients experienced intensive care unit admission, with an average stay of 7.45 days, 19.5% received mechanical ventilation, 12.3% received cardiopulmonary resuscitation, and 15.5% had a feeding tube placement. A statistical analysis using a multiple logistic regression model with random effects showed that younger age, higher household income, primary diagnoses of diseases (ischemic heart disease, infectious disease, chronic lung disease, or chronic heart disease), and characteristics of care setting (large hospitals and facilities located in metropolitan areas) were significantly associated with the likelihood of receiving high-intensity care at the end of life.

Conclusion:

A substantial number of older adults in Korea experienced high-intensity end-of-life care. Both individual and institutional factors were associated with the likelihood of receiving high-intensity care. Gaining an understanding of the intensity of care at the end of life and the impact of the determinants would advance efforts to improve quality of care at the end of life for older adults in Korea.
Diet Quality and Physical Fighting Among Youth: A Cross-National Study
Authors: Jackson Dylan B. , Vaughn Michael G.
Published: January 2018

The predictors of engaging in physical violence appear to be quite diverse, covering an array of social and psychological risk factors. The present study expands upon this literature by exploring the link between diet quality and physical fighting during early adolescence using cross-national data from the 2005/2006 Health Behaviors of School Children (HBSC) survey. The results reveal that the rate of physical fighting was 40% higher among youths with lower quality diets, whereas the odds of frequent physical fighting were 68% higher, relative to youths with better diets. Ancillary analyses reveal that (a) the link between diet quality and physical fighting was significantly larger among females and (b) significant associations between diet quality and physical fighting were detected in 38 of the 40 countries examined. Strategies designed to improve diet quality among youth may have the added benefit of reducing the likelihood of physical fighting and its negative sequelae.
Failure in welfare partnerships – A gender hypothesis: Reflections on a serendipity pattern in Local Safeguarding Children Boards
Authors: Dudau Adina I , McAllister Laura
Published: January 2018

This article examines the roles that occupational segregation and gender bias in the welfare professions play in persistent failures in inter-agency and inter-professional collaborations. Drawing on case study evidence from a Local Safeguarding Children Board in England, a ‘serendipity pattern’ of gender dominance is identified within professions affecting inter-professional collaborations such as those prevalent in Local Safeguarding Children Boards. As we assign this pattern ‘strategic interpretation’, we suggest that policy measures taken to augment the effectiveness of welfare partnerships have, so far, paid insufficient attention to the critical variable of gender, due to over-emphasis on the organisations, rather than the professions, involved. The article’s contribution to practice is unravelling the potential of this oversight to contribute to failure to establish a collaborative mind-set. Our contribution to theory is highlighting specific cultural barriers to inter-professional collaborations, unravelling the power differentials rooted in gender inequity in public sector workforces and challenging professional and organizational traditionalism. In doing so, we offer empirical evidence of the ‘gender hypothesis’ in welfare partnerships and indicate how future investigations might be pursued in this area.
A novel three-dimensional elliptical vibration cutting device based on the freedom and constraint topologies theory
Authors: Lin Sheng , Kong Xi , Wang Chun , Zhai Yun , Yang Liang
Published: January 2018

Aiming at the issue of the lack of the design theory for the three-dimensional elliptical vibration cutting device, a compliant mechanism with two rotations and one translation is synthesized based on the theory of freedom and constraint topologies. And a three-dimensional elliptical vibration cutting device is proposed on the basis of the compliant mechanism. The relationship between the critical speed and the length of the tool bar is analyzed. Simulation is conducted to analyze the influence of parameters on the output ellipse. Experiments are conducted to verify the validity of the elliptical vibration cutting device. The relationship between the roughness and the cutting speed is obtained. Experiments with different driving frequencies are conducted without the change of other parameters. Results show that the proposed compliant mechanism is feasible for the elliptical vibration cutting device. Compared with the common cutting, the new elliptical vibration cutting device has a better performance in the processing effect. This provides an important reference for design of the elliptical vibration cutting device.
Adaptive on-line compensation model on positioning error of ball screw feed drive systems used in computerized numerical controlled machine tools
Authors: Li Tie-jun , Zhao Chun-yu , Zhang Yi-min
Published: January 2018

The positioning error of ball screw feed systems is mainly caused by thermal elongation of the screw shaft in machine tools. In this article, an adaptive on-line compensation method of positioning error for the ball screw shaft is established. In order to explore the thermal–solid mechanism of ball screw feed drive systems, the experiments were carried out. An exponential fitting equation is presented to obtain the temperature relationship between the temperature sensitive point and its center of each heat source based on the finite element method of the feed drive system. Consequently, based on time and position exponential distribution functions, a variable separation model of heat transfer is established. Furthermore, based on the heat transfer model of multiple varying and moving heat sources, an adaptive on-line analytical compensation model of positioning error is presented. Finally, the effect of the adaptive on-line analytical compensation model of positioning error is verified through the experiments. And, this model has self-adaptive ability and robustness. Therefore, this adaptive on-line analytical compensation model based on the heat transfer theory can be applied in real-time compensation of positioning error.
Female Chess Players Outperform Expectations When Playing Men
Authors: Stafford Tom
Published: January 2018

Stereotype threat has been offered as a potential explanation of differential performance between men and women in some cognitive domains. Questions remain about the reliability and generality of the phenomenon. Previous studies have found that stereotype threat is activated in female chess players when they are matched against male players. I used data from over 5.5 million games of international tournament chess and found no evidence of a stereotype-threat effect. In fact, female players outperform expectations when playing men. Further analysis showed no influence of degree of challenge, player age, nor prevalence of female role models in national chess leagues on differences in performance when women play men versus when they play women. Though this analysis contradicts one specific mechanism of influence of gender stereotypes, the persistent differences between male and female players suggest that systematic factors do exist and remain to be uncovered.
Confabulation or experience? Implications of out-of-body experiences for theories of consciousness
Authors: Carruthers Glenn
Published: January 2018

Difficulties in distinguishing veridical reports of experience from confabulations have implications for theories of consciousness. I develop some of these implications through a consideration of out-of-body experiences (OBEs). Do these variations indicate individual variation in experience or are they post-hoc confabulations, stories told by subjects to themselves in an attempt to make sense of the core phenomenology? I argue that no existent or possible evidence would be sufficient to favour one hypothesis over the other. How such evidence is interpreted depends on prior commitments to one or other of these hypotheses or to a theory of consciousness that is not neutral as to these hypotheses. One of these types of theory, namely vehicle theories, has difficulty accommodating the existence of confabulations and so allows for only the elaborate phenomenology hypothesis. Because we cannot know that reports are not confabulations, vehicle theories are insufficient to explain OBEs.
Positive Psychology and the legitimation of individualism
Authors: Cabanas Edgar
Published: January 2018

Positive Psychology (PP) has been firmly institutionalized as a worldwide phenomenon, especially in the last decade. Its promise of well-being has captured many people’s longings for solutions in times of significant social uncertainty, instability, and insecurity. The field, nevertheless, has been severely criticized on multiple fronts. This article argues that positive psychology is characterized by a narrow sense of the social as well as by a strong individualistic bias that reflects the core beliefs of neoliberal ideology. In this regard, the present paper aims to illustrate the extent to which individualism is essential to understanding the theoretical and empirical foundations of PP’s conceptualization of happiness. Additionally, the paper questions whether positive psychology and its individualist conception of human well-being are not themselves contributing to sustain and create some of the dissatisfaction to which they promise a solution.
‘On me bed, son’: The (Re)presentation of (emphasised) femininity in English ‘tabloid’ newspaper coverage of Euro 2016
Authors: Domeneghetti Roger
Published: January 2018

This study explores the gendered narratives constructed in the coverage of the 2016 Union of European Football Associations (UEFA) European Championship football tournament in selected English newspapers. Using qualitative textual analysis, the study tests the efficacy of three established classifications and draws them together with a new, fourth classification thereby creating a typology of the (re)presentations of emphasised femininity. The analysis suggests that despite the increasing prevalence of female sports journalists and the increasing coverage of female athletes in a variety of sports, including football, the reporting of men’s football in the English popular press continues to cast women in subordinate and sexualised roles. Furthermore, women who challenge these roles, particularly those who establish their own voice within the event’s discursive space, are criticised.
Toward Active Partnership: Notice of Procedural Safeguards Designed for Parent Use
Authors: Dinnesen Megan Schneider , Kroeger Stephen D.
Published: January 2018

Procedural safeguards have been in place for years with the intention of protecting the rights of parents and their children with disabilities. Despite the promises of the Individuals With Disabilities Education Act, parents have not mastered the tools they need to be active participants in their child’s special education. Educators must inform parents of children with disabilities of their rights and responsibilities in documents that clearly communicate the expectation that parents can and will advocate for their children. Review of the documents currently used to inform parents of their rights, as well as relevant literature on the topic, indicated that parents are not empowered to give informed consent. This study sought to talk directly with parents of children with disabilities to explore whether a redesigned notice of procedural safeguards document is warranted and could support parents’ engagement in their child’s special education. Interview data collected demonstrated that parents of children with disabilities see a need for revised documents and need functional information from the schools. The implementation of rights notices that authentically inform parents could bring about a shift in the culture of special education and include all parents as active participants in their child’s special education.
Performance Measures for Health Care Teams: A Review
Authors: Marlow Shannon , Bisbey Tiffany , Lacerenza Christina , Salas Eduardo
Published: January 2018

Interest in effective health care teamwork has advanced in recent years. To ensure these teams are performing effectively, valid and reliable measurement is necessary. This review identifies and organizes information about measures of health care team performance by addressing the following objectives: (a) identify existing measures of health care team performance ( k = 70), (b) summarize validity evidence (i.e., construct and content validity), (c) summarize reliability information (i.e., interrater/interobserver reliability and internal consistency), (d) summarize information pertaining to the use and implementation of the measures (i.e., generalizability, instrument type, and clarity of language), and (e) identify the teamwork content included in the measures. These findings can aid researchers and practitioners in selecting a measure that is appropriate for a specific context. This review also illuminates areas where future research is needed by identifying types of reliability, validity, and teamwork content that have been largely unaddressed.
Safety Climate Among Nontraditional Workers in Construction: Arguing for a Focus on Construed External Safety Image
Authors: Stiehl Emily , Forst Linda
Published: January 2018

Safety climate, employees’ perceptions of work-related safety, 1 has been promoted as a leading indicator of workplace safety in construction. 2 , 3 While research has primarily examined internal organizational sources (e.g., manager attitudes, formal organizational policies) on these perceptions, external sources of information might be more relevant to construction workers in nontraditional jobs who work for a limited time and/or have limited interaction with other employees. This paper argues for the future development of a construed external safety image scale to measure employees’ perceptions about how external groups view their organization’s safety. 4 The construed external safety image would capture the external sources that nontraditional workers use to assess safety climate and will allow public health researchers to identify and change dangerous workplaces while more effectively communicating information about safe workplaces to workers. The public health relevance of safety climate and construed external safety image for monitoring and communicating safety to nontraditional workers require examination.
Centralization of Cleft Lip and Palate Services in the United Kingdom
Authors: Stock Nicola Marie , Anwar Hamza , Sandy Jonathan R. , Rumsey Nichola
Published: January 2018

Background:

Since the implementation of centralized services in the United Kingdom for those affected by cleft lip and/or palate (CL/P), several studies have investigated the impact of service rationalization on the delivery of care. While large-scale quantitative studies have demonstrated improvements in a range of patient outcomes, and smaller studies have reported on the benefits and challenges of centralization from the views of health professionals, little research has attempted to capture the patient perspective. Furthermore, few studies have investigated the views of adult “returners” who have undergone treatment both pre- and postcentralization.

Methods:

Qualitative data relevant to the subject of this article were extracted from 2 previous larger studies carried out between January 2013 and March 2014. A total of 16 adults born with CL/P contributed data to the current study. These data were subjected to inductive thematic analysis.

Results:

The findings suggest that centralization of CL/P services has considerably enhanced the patient experience. Specifically, the overall standard and coordination of care has improved, service delivery has become more patient centered, and access to professional psychological support and peer support has greatly improved patients’ capacity to cope with the associated emotional challenges.

Conclusions:

The data collected provide additional insight into the impact of centralization from the perspective of a largely unexplored patient population. In combination with other literature, these findings are also relevant to future efforts to centralize other specialist services around the world.
Effectiveness of Basic Life Support Training for Middle School Students
Authors: Aloush Sami , Tubaishat Ahmad , ALBashtawy Mohammed , Suliman Mohammad , Alrimawi Intima , Al Sabah Ashraf , Banikhaled Yousef
Published: January 2018

Bystander cardiopulmonary resuscitation improves survival after out-of-hospital cardiac arrest. This study aimed to assess the effectiveness of a basic life support (BLS) educational course given to 110 middle school children, using a pretest posttest design. In the pretest, students were asked to demonstrate BLS on a manikin to simulate a real-life scenario. After the pretest, a BLS training course of two sessions was provided, followed by posttest on the same manikin. Students were assessed using an observational sheet based on the American Heart Association’s BLS guidelines. In the pretest, students showed significant weakness in the majority of guidelines. In the posttest, they demonstrated significant improvement in their BLS skills. BLS training in the middle school was effective, considering the lack of previous skills. It is recommended that BLS education be compulsory in the school setting.
Sedative Plasma Concentrations and Delirium Risk in Critical Illness
Authors: Stollings Joanna L. , Thompson Jennifer L. , Ferrell Benjamin A. , Scheinin Mika , Wilkinson Grant R. , Hughes Christopher G. , Shintani Ayumi K. , Ely E. Wesley , Girard Timothy D. , Pandharipande Pratik P. , Patel Mayur B.
Published: January 2018

Background: The relationship between plasma concentration of sedatives and delirium is unknown. Objective: We hypothesized that higher plasma concentrations of lorazepam are associated with increased delirium risk, whereas higher plasma concentrations of dexmedetomidine are associated with reduced delirium risk. Methods: This prospective cohort study was embedded in a double-blind randomized clinical trial, where ventilated patients received infusions of lorazepam and dexmedetomidine. Plasma concentrations of these drugs and delirium assessments were measured at least daily. A multivariable logistic regression model accounting for repeated measures was used to analyze associations between same-day plasma concentrations of lorazepam and dexmedetomidine (exposures) and the likelihood of next-day delirium (outcome), adjusting for same-day mental status (delirium, coma, or normal) and same-day fentanyl doses. Results: This critically ill cohort (n = 103) had a median age of 60 years (IQR: 48-66) with APACHE II score of 28 (interquartile range [IQR] = 24-32), where randomization resulted in assignment to lorazepam (n = 51) or dexmedetomidine (n = 52). After adjusting for same-day fentanyl dose and mental status, higher plasma concentrations of lorazepam were associated with increased probability of next-day delirium (comparing 500 vs 0 ng/mL; odds ratio [OR] = 13.2; 95% CI = 1.4-120.1; P = 0.02). Plasma concentrations of dexmedetomidine were not associated with next-day delirium (comparing 1 vs 0 ng/mL; OR = 1.1; 95% CI = 0.9-1.3; P = 0.45). Conclusions: In critically ill patients, higher lorazepam plasma concentrations were associated with delirium, whereas dexmedetomidine plasma concentrations were not. This implies that the reduced delirium risk seen in patients sedated with dexmedetomidine may be a result of avoidance of benzodiazepines, rather than a dose-dependent protective effect of dexmedetomidine.
It’s All about Race: How State Legislators Respond to Immigrant Constituents
Authors: Gell-Redman Micah , Visalvanich Neil , Crabtree Charles , Fariss Christopher J.
Published: January 2018

How do elected representatives respond to the needs of immigrant constituents? We report the results of a field experiment on U.S. state legislators in which the nativity, likelihood of voting, and race/ethnicity of a hypothetical constituent are independently manipulated. The experimental design allows us to contribute new insights by isolating the various elements that may impede the connection between immigrants and elected representatives. Moreover, we explore racial/ethnic identities beyond black and white by including Latino and Asian aliases. Contrary to expectations, nativity and voting status do not affect response rates. Instead, legislator behavior appears to be driven by racial/ethnic bias. Whites benefit from the highest response rate, while blacks, Hispanics, and Asians all receive lower rates, respectively. This bias follows a partisan logic. The low response rate for Hispanic constituents comes primarily from Republican legislators, whereas Asians experience bias from representatives of both parties. We argue that this difference may result from Hispanic identity sending a stronger signal about partisan affiliation, or from a prejudicial view of Asians as outsiders. In this last interpretation, rather than the model minority, Asians become the excluded minority.
Poorly Differentiated Neuroendocrine Carcinoma of the Sigmoid Tract in Long-Standing Ulcerative Colitis: Report of a Case and Review of the Literature
Authors: Bolzacchini Elena , Chini Claudio , Cortelezzi Claudio Camillo , Vallini Ilaria , Pinotti Graziella , La Rosa Stefano , Uccella Silvia
Published: January 2018

A 37-year-old male with long-standing and extensive ulcerative pancolitis developed a rapidly lethal poorly differentiated neuroendocrine carcinoma (NEC) in the sigmoid colon. Prior biopsies obtained from multiple sites of the colon during endoscopic surveillance showed minimal inflammatory changes and no sign of dysplasia. Patients with inflammatory bowel disease (IBD) are at increased risk of colorectal malignancies, and adenocarcinoma is the most common type of colorectal neoplasm associated with ulcerative colitis and Crohn’s disease, but other types of epithelial and nonepithelial tumors have also been described in IBD. NECs arising in the setting of ulcerative colitis are very rare and are reported as anecdotic findings. We describe the clinicopathological features of an IBD-related NEC and review the previously reported cases.
Prevalence of Vitamin D Deficiency in Patients With Talar Osteochondral Lesions
Authors: Telleria Jessica J. M. , Ready Lauren V. , Bluman Eric M. , Chiodo Christopher P. , Smith Jeremy T.
Published: January 2018

Background:

Vitamin D deficiency affects over 1 billion people worldwide and is common in foot and ankle patients. The prevalence in those with osteochondral lesions of the talus (OLTs) is unknown. This study identified the prevalence and risk factors for hypovitaminosis D in patients with an OLT.

Methods:

Serum 25(OH)D levels were obtained from patients presenting with an OLT from May to November during 2007 to 2016. Hypovitaminosis D was defined as 25(OH)D less than 30 ng/mL (75 nmol/L). Patients presenting with an acute ankle sprain (AS) during the same months served as a control group. Specific medical risk factors for hypovitaminosis D were recorded. The final OLT population included 46 patients (31 women [67.4%]; mean [SD] age 43.6 [14.8] years). The comparison AS group had 40 patients (32 women [80.0%]; mean [SD] age 56.2 [13.0] years).

Results:

The mean (SD) 25(OH)D in the OLT and AS cohorts were 31.2 (12.6) ng/mL and 37.1 (13.5) ng/mL, respectively ( P = .039). Hypovitaminosis D was identified in 54% of the OLT population and 28% of the AS population ( P = .012).

Conclusion:

Hypovitaminosis D is intimately related to decreased bone mineral density. This study identified a significantly higher rate of hypovitaminosis D in patients with an OLT compared to a cohort of AS patients. These findings suggest that when patients present with an OLT, health care providers should consider evaluating for and treating hypovitaminosis D.

Level of Evidence:

Level III, comparative study.
Treatment of AO/OTA Type C Pilon Fractures Through the Anterolateral Approach Combined With the Medial MIPO Technique
Authors: Kim Gi Beom , Shon Oog-Jin , Park Chul Hyun
Published: January 2018

Background:

The purpose of this study was to evaluate the clinical and radiographic results of the treatment of AO/OTA type C pilon fracture via the anterolateral approach using a low-profile plate combined with medial minimally invasive plate osteosynthesis (MIPO).

Methods:

We retrospectively reviewed 28 ankles with AO/OTA type C pilon fractures that were treated using the anterolateral approach combined with medial MIPO. Mean age was 46 years (range, 19 to 75), and the mean follow-up period was 25 months (range, 14 to 50). Clinical results were assessed using the visual analogue scale (VAS) and the American Orthopaedic Foot & Ankle Society (AOFAS) Ankle-Hindfoot Scale. Range of motion (ROM) of the ankle joint was measured, and postoperative complications were investigated via chart review.

Results:

The VAS and AOFAS Ankle-Hindfoot Scale were 2 and 89, respectively, at the last follow-up. Ankle ROM at the last follow-up was 13 degrees (range, 5 to 20) in dorsiflexion and 38 degrees (range, 35 to 40) in plantarflexion. All the fractures united without additional surgery. One patient (3.6%) had a deep infection at the fibular fracture site, and 1 patient (3.6%) had partial skin necrosis.

Conclusion:

This combined technique for AO/OTA type C pilon fracture resulted in good ROM of the ankle joint with reasonable function with a fairly low wound complication rate. However, further research on defined indications with a comparison group from multiple centers is necessary to determine if this technique is better than alternative surgical approaches.

Level of Evidence:

Level IV, case series.
Endocardial Changes in Nonvalvular Atrial Fibrillation Without Atrial Thrombus—Thrombomodulin and Tissue Factor Pathway Inhibitor
Authors: An Kang , Mei Ju , Zhu Jiaquan , Tang Min
Published: January 2018

Atrial fibrillation (AF) is a well-known cause for thromboembolism. Although blood stasis in the left atrium and hypercoagulable state of the blood have been emphasized as important mechanisms, limited attention has been paid to the endocardial changes in maintaining the balance of local coagulation, which may also contribute to the thrombus formation in AF. In the present study, left atrial appendage samples were obtained at heart surgery from nonvalvular AF and non-AF patients without atrial thrombus. Immunohistochemistry for endocardial markers including thrombomodulin (TM) and tissue factor pathway inhibitor (TFPI) was performed and semiquantitatively graded. In immunohistochemistry analysis, decreased expression of TM was found in patients with nonvalvular AF compared with those without AF ( P < .001). There was no difference in TFPI expression between the 2 groups ( P = .213). Patients with TM score of 0 or 1 seemed to have larger left atrial diameter (LAD) than those with TM score of 2 or 3 (44.0 (7.9) vs 40.6 (3.9); P = .009), while no relationship between LAD and TFPI expression was found (43.4 (7.0) vs 42.9 (7.8); P = .485). In conclusion, TM expression in the atrial endocardium is decreased in nonvalvular AF without atrial thrombus, while TFPI expression is not. Downregulated TM expression might be associated with enlarged LAD.
Comparative Evaluation of Biological Performance, Biosecurity, and Availability of Cellulose-Based Absorbable Hemostats
Authors: Wu Yadong , Wang Fang , Huang Yudong
Published: January 2018

Hemorrhage remains a leading cause of death after trauma, and developing a hemostat with excellent performance and good biosecurity is an extremely active area of research and commercial product development. Although oxidized regenerated cellulose (ORC) has been developed to address these problems, it is not always efficient and its biosecurity is not perfect. We aimed to refine ORC via a simple and mild neutralization method. The prepared neutralized oxidized regenerated cellulose (NORC) showed a superior gel property due to its chemical structure. The biological performance of both ORC and NORC was systematically evaluated; the results showed that ORC would induce erythema and edema in the irritation test, whereas NORC did not cause any adverse inflammation, indicating NORC had desirable biocompatibility. We further demonstrated that NORC confirmed to the toxicity requirements of International Organization for Standardization (ISO) standards; however, ORC showed an unacceptable cytotoxicity. The rabbit hepatic defect model stated that NORC exhibited better ability of hemostasis, which was attributed to its significant gel performance in physiological environment.
Tuning of robust fractional-order phase-lead compensators using pole placement and pole-zero ratio minimization
Authors: Safaei Marzieh , Tavakoli Saeed
Published: January 2018

This paper deals with the tuning of robust fractional-order phase-lead compensators to provide desired time-domain specifications. A simple analytical design technique, which is based on minimization of a compensator’s pole-zero ratio subject to pole placement requirements, is developed. The necessary and sufficient conditions for the feasibility of the problem and determination of optimal compensator parameters are provided. To have a robust compensator, a desired maximum sensitivity is provided by properly choosing the compensator’s fractional-order in the acceptable range. Finally, illustrative examples are presented to evaluate the performance and effectiveness of the proposed method.
Lessons in Program Evaluation: The ACTV Batterer Program Study and Its Claims
Authors: Gondolf Edward W. , Bennett Larry , Mankowski Eric
Published: January 2018

The “Evaluation of the Acceptance and Commitment Therapy (ACT) curriculum for domestic violence offenders” illustrates the methodological issues associated with interpreting program evaluations and applying them to policy. Despite the “preliminary” evidence, the authors promote ACTV as more effective in terms of recidivism compared with DU/CBT (cognitive-behavioral therapy) programming. A more critical consideration of the research, however, exposes further limitations that counter the initial speculations and interpretations of the study outcome. Consequently, the effectiveness of ACTV over the DU/CBT option remains in question and raises the need for a broader discourse on program effectiveness.
Experimental feedback linearisation of a non-smooth nonlinear system by the method of receptances
Authors: Lisitano Domenico , Jiffri Shakir , Bonisoli Elvio , Mottershead John E
Published: January 2018

Input–output partial feedback linearisation is experimentally implemented on a non-smooth nonlinear system without the necessity of a conventional system matrix model for the first time. The experimental rig consists of three lumped masses connected and supported by springs with low damping. The input and output are at the first degree of freedom with a non-smooth clearance-type nonlinearity at the third degree of freedom. Feedback linearisation has the effect of separating the system into two parts: one linear and controllable and the other nonlinear and uncontrollable. When control is applied to the former, the latter must be shown to be stable if the complete system is to be stable with the desired dynamic behaviour.
A Community-Partnered Approach to Inform a Culturally Relevant Health Promotion Intervention for Stroke
Authors: Eisenstein Amy R. , Song Sarah , Mason Maryann , Kandula Namratha R. , Richards Christopher , Aggarwal Neelum T. , Prabhakaran Shyam K.
Published: January 2018

Background. The purpose of this study was to generate information from multiethnic, high-risk communities to inform the creation of culturally relevant health promotion intervention for increasing early hospital arrival after stroke. Methods. The study employed a qualitative design, using focus groups with African American, Caucasian, and Hispanic adults in two Chicago community areas. The study relied heavily on stakeholder input in creating the focus group guide, recruiting participants, and interpreting the analysis. Results. Six focus groups gained information from 51 participants, including insights and perspective on participants’ stroke experience and knowledge as well as on facilitators and barriers to calling 9-1-1. Qualitative analysis uncovered themes relating to risk factors, symptoms, knowledge of stroke mechanisms, experience of acute stroke, help seeking, stroke education, recovery, treatment, and emotions. Communities were closely aligned in their knowledge of stroke, but had differing ideas around stroke education and dissemination of education. Discussion. This study identified nuances in real-world barriers to receiving acute stroke services in minority and disadvantaged communities in Chicago neighborhoods. Our findings indicated significant amount of variation by race/ethnicity and, in particular, a lack of similarities based on race/ethnic groups in different communities. These findings underscore the importance of working with communities to fully understand the community-level dynamics that occur.
Evaluation of long-term outcome and prognostic factors of feline squamous cell carcinomas treated with photodynamic therapy using liposomal phosphorylated meta-tetra(hydroxylphenyl)chlorine
Authors: Flickinger Irene , Gasymova Eva , Dietiker-Moretti Simona , Tichy Alexander , Rohrer Bley Carla
Published: January 2018

Objectives

The aim of this study was to evaluate the efficacy, long-term outcome and prognostic factors of feline squamous cell carcinoma (SCC) treated with photodynamic therapy (PDT).

Methods

Cats with histologically verified SCC of the head and neck received an intravenous injection of liposomal phosphorylated meta-tetra(hydroxylphenyl)chlorine (mTHPC) and 4 h later 652 nm light was delivered by a diode laser. One group received ⩽10 J/cm2, the other 20 J/cm2. Tumour response and duration were analysed with stage, tumour diameter, location and treatment intensity as prognostic factors.

Results

In total, 63 lesions in 38 cats underwent treatment with ⩽10 J/cm2 (n = 22) and 20 J/cm2 (n = 41). Overall response rate was 84% (complete remission 61%, partial remission 22%) with a mean progression-free interval of 35 months (median not reached) and a median overall survival time of 40 months (95% confidence interval 33–47). With regard to tumour stage, invasiveness yielded a highly significant worse outcome ( P <0.017). All patients with invasive tumours showed progression at less than 6 months. Larger lesions were associated with inferior control and treatment intensity, and tumour location did not influence response and duration.

Conclusions and relevance

PDT using a systemic photosensitiser leads to excellent long-term tumour control in the majority of cats. However, invasive and large tumours had a clearly inferior outcome, even if treated with the higher-dose intensity. This suggests that advanced lesions are not indications for PDT.
Hereditary cataracts in Russian Blue cats
Authors: Nygren Karin , Jalomäki Sari , Karlstam Lena , Narfström Kristina
Published: January 2018

Objectives

The purpose of this study was to investigate the prevalence of cataracts in the Russian Blue breed of cats in Sweden, and to describe the clinical appearance of this presumed inherited form of cataract.

Methods

A total of 66 Russian Blue cats were examined in Sweden, between March and October 2014, using standard examination techniques. The examined cats were between 3 months and 14 years of age. Pedigrees were collected from all examined cats for genetic studies.

Results

Mild-to-severe forms of mainly bilateral cataracts were observed in 22/66 examined Russian Blue cats of both sexes. Two affected cats were <1 year of age. The most frequently observed appearance of a cataract was a small triangular, Y-shaped or circular opacity at the border of the posterior nucleus and the anterior part of the posterior cortex, which caused no observable visual impairment. More extended forms were observed in 6/22 cats, with involvement of both the nucleus and either the entire cortex or parts of the posterior and/or anterior cortex. Visual impairment or blindness was observed in the latter six cases. Pedigree analyses indicated a simple autosomal recessive mode of inheritance for the defect, although a dominant mode with incomplete penetrance could not be excluded.

Conclusions and relevance

This study indicates that the Russian Blue breed of cat is affected by hereditary cataracts. The high prevalence in young cats and the characteristic location of the most frequently observed defect in the study suggest an early onset type of cataract. The breeders should be aware of this defect and have their cats examined by a veterinary ophthalmologist before breeding of an individual Russian Blue cat is considered.
Interfaces
Authors: Sebag J. , Hageman G. S.
Published: January 2018

There are important similarities in molecular composition and structural organization of the interface between the vitreous and retina and that between the retina and retinal pigment epithelium. It is striking that the two most common causes of severe vision loss in the western world involve neovascularization at these interfaces; i.e., proliferative diabetic vitreoretinopathy at the vitreo-retinal interface and exudative age-related macular degeneration at the retina-retinal pigment epithelium interface. Improved knowledge of the physiology of these interfaces will lead to a better understanding of the effects of aging and diseases, especially those that involve neovascularization. Such advances will no doubt result in new treatment strategies offering more effective therapy, and, even more importantly, perhaps providing prevention from these devastating causes of blindness.
A Comparison of Topical Mequitazine and Disodium Cromoglycate in Allergic Conjunctivitis Induced by a Specific Conjunctival Provocation Test
Authors: Dupin O. , Trinquand C. , Persi L. , Bousquet J. , Robert F. , Arnaud B
Published: January 2018

Purpose

Twenty-two people with a history of grass pollen allergic conjunctivitis were enrolled outside the pollen season in this study to compare the efficacy of 0.05% mequitazine eyedrops with topical 2% disodium cromoglycate.

Methods

This randomized, double-blind study compared right and left eyes. Subjects received 2% disodium cromoglycate eyedrops in one eye and mequitazine vehicle in the fellow eye 4 times daily for 4 days. For the last instillation, mequitazine vehicle was replaced by one drop of 0.05% mequitazine and 15 min later a conjunctival provocation test (CPT) with grass pollen was performed.

Results

The sum of the scores for hyperemia and itching, and total composite score were lower after 0.05% mequitazine than after 2% disodium cromoglycate (p < 0.0001 in each case). The allergen threshold dose which elicited a positive allergic response was higher in the mequitazine group (p < 0.001). Both treatments showed good tolerance upon instillation. No adverse events related to study treatment occurred.

Conclusions

These results demonstrate the superior efficacy of a single drop of 0.05% mequitazine 15 min before CPT compared with 2% disodium cromoglycate 4 times daily for 4 days.
A Topical or Oral Carbonic Anhydrase Inhibitor to Control Ocular Hypertension after Cataract Surgery
Authors: Abbasoǧlu Ö. E. , Tekeli O. , Çelikdoǧan A. , Gürsel E.
Published: January 2018

Purpose

To compare the effects of oral acetozolamide and topical 2% dorzolamide to prevent ocular hypertension after cataract surgery.

Methods

This prospective, randomized study comprised 62 consecutive patients who had extracapsular cataract extraction and posterior chamber intraocular lens implantation. Patients received either oral acetozolamide (Diazomide®) 250 mg three times daily or topical dorzolamide 2% (Trusopt®) three times daily, for three days. Intraocular pressures (IOP) were measured by Goldmann applanation tonometry preoperatively and 16, 40, 64 hours postoperatively.

Results

IOP in the dorzolamide group peaked at 16 hours and had returned to preoperative values by 40 hours. In the acetozolamide group mean IOP was significantly higher than preoperative values at 16, 40 and 64 hours (p<0.05). At all three postoperative measurement times, mean IOP was significantly higher in the acetozolamide group (p<0.05).

Conclusions

Topical dorzolamide 2% offers better IOP control than oral acetozolamide to prevent ocular hypertension after cataract surgery.
Prevention of Corneal Keratocyte Apoptosis after Argon Fluoride Excimer Laser Irradiation with the Free Radical Scavenger Ubiquinone Q10
Authors: Brancato R. , Schiavone N. , Siano S. , Lapucci A. , Papucci L. , Donnini M. , Formigli L. , Orlandini S. Zecchi , Carella G. , Carones F. , Capaccioli S.
Published: January 2018

Purpose

To assess in vitro the potential of the free radical scavenger ubiquinone Q10 in preventing keratocyte apoptosis after argon fluoride (ArF) excimer laser irradiation.

Methods

Cultured rabbit keratocytes were irradiated at very low single-pulse laser fluences. The cumulative effects generated by three total fluence doses between 12 and 45 mJ/cm2, representative of single-pulse subablative doses during photorefractive keratectomy (PRK) in humans, were evaluated. We employed the following parameters to compare pretreated (10 μM ubiquinone Q10) and untreated samples: 1) number and morphology of living cells by Trypan blue test and ultramicroscopy, respectively; 2) level of free-radical formation assessed by malonaldehyde quantitation; 3) cellular energy level evaluated by ATP assay.

Results

Excimer laser irradiation kills cultured keratocytes by inducing apoptosis. The effect increases with the cumulative fluence dose. In the samples pretreated with ubiquinone Q10 there were significantly fewer cumulative apoptotic events than in the untreated ones. Quantitative analysis of malonaldehyde cellular levels suggested this protective action of ubiquinone Q10 was connected with its ability to scavenge laser-generated free radicals. ATP assay also confirmed that it raised cellular energy levels.

Conclusions

The treatment of corneal keratocytes with relatively low concentrations of ubiquinone Q10 can prevent apoptosis after ArF excimer laser irradiation. If these findings are confirmed on human keratocytes this treatment could be usefully exploited in the PRK surgical procedure. That might lead to a reduction in the occurrence of haze and curvature regression triggered by programmed cell death.