bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic Effects of Aloe vera (L.) Burm.f. and Vitis vinifera L. Combination Cream on Wound Healing in Second-Degree Burn Model in Rats: Quantiﬁcation of Compounds and VEGF & TGFβ Gene Expression
Authors: Moayeri Ardeshir , Ramz Kholoud , Karimi Elahe , Azizi Monireh , Abbasi Naser , Aidy Ali , Bahmani Mahmoud
Published: April 2022

Finding more efficient agents with fewer side effects for the treatment of burns has been a concern for researchers. The current study aims to assess Aloe vera (L.) Burm.f. and Vitis vinifera L. extract combination (AVEC) effects on wound healing in rats compared with silver sulfadiazine (SSD). Identification of individual polyphenols of the plant extracts was performed by HPLC. The animals were randomly divided into twelve groups. Standard second-degree burn wounds were induced on the back. Groups were treated with Aloe vera (A.V) and Vitis vinifera (V.V) creams at concentrations of 0.5, 1, 1.5, and 2% with ED50 values of 1.5 ± 0.02 and 1.4 ± 0.08 %, respectively. The other group was treated with an AVEC cream (1.5%). The samples of burned skin tissue were collected from the rats for histopathological examination. To evaluate the expression of VEGF and TGFβ1, the real time-PCR method was used. Kaempferol was only detected in Aloe. This study revealed that AVEC cream exhibits significant wound healing activity. VEGF and TGFβ1 had a significant increase in the AVEC. Based on our findings, AVEC cream can be a therapy of choice for burn injuries.
Hymenocallis caribaea (L); una planta con potencial agroindustrial, medicinal y farmacológico
Authors: Salas Olivet Eva , Ruiz Cardona Jenny , Marcía Fuentes Jhunior Abrahan
Published: April 2022

Hymenocallis caribaea L., conocida comúnmente como Lirio de San Juan, es una especie de planta geófita perteneciente a la familia de las amarilidáceas, se encuentra distribuida en Centroamérica y en Cuba, además es considerada medicinal. Por lo anterior, esta investigación tuvo como objetivo evaluar la toxicidad aguda dérmica y oral de los extractos acuosos e hidroalcohólicos a partir de las hojas y los bulbos de esta planta, para su potencial aprovechamiento agroindustrial, medicinal y farmacológico. Para su alcance se empleó estudios in vivo a partir de ratas Winstar, empleando dosis límite de 2000 mg/kg. Los resultados indicaron que existió una tendencia al incremento del peso de las ratas durante la experimentación, además no se observó mortalidad, ni cambios en la conducta en los animales, lo que sugiere la ausencia de efectos tóxicos sistémicos. Asimismo, estos resultados demostraron la inocuidad de esta planta cuando se aplica de forma aguda por las vías ensayadas.
Reuniting Speech-Impaired People with Their Voices: Sound Technologies for Disability and Why They Matter for Organisation Studies
Authors: Napolitano Domenico
Published: April 2022

This paper intends to provide an analysis of sound and voice technologies for speech-impaired people regarded as sites of knowledge production about disability. The study will focus on the case of Google’s project to reunite speech-impaired users with their voices using voice cloning technology, an evolution of speech synthesis that allows the reconstruction of the sonic and timbral characteristics of a person’s voice. Addressing both the narratives and representations – which reveal a medical model of disability as an external flaw to be cured through technology – and the material practices and operations enacted by those technologies – which highlight epistemologies of human variation, embodiment and accessibility built into the software –, the paper shows that disability as a social construct is co-constituted in the interaction of these levels. In this regard, the following research proposes a socio-technical model of disability theorisation that combines techno-scientific knowledge, cultural values, images of the user, material operations and organisational practices. From this perspective, the paper argues that the study of disabilities would benefit from the contribution of organisation studies and media studies in order to reveal the ‘constructedness’ of disability and able-bodiedness, and the role of media technologies, institutions, and representations in producing and upholding – as well as potentially challenging – such constructions.
DEVELOPMENT OF PROFESSIONAL COMPETENCIES IN TEACHERS: THE ROLE OF TUTOR AND MENTOR
Authors:   Educational Psychologist and Pedagogist, Department of Human Science, University of Verona, Verona, Italy, Cramerotti Sofia
Published: April 2022

The purpose of this article is to identify the role played by tutors and mentors in accompanying novice teachers within a specialization course aimed at supporting teachers for the classroom inclusion of students with disabilities. The specific aim of this qualitative research was to investigate the expert teachers’ features and how they (in the role of tutors and mentors) perceive the distinct role they play in the development of novice teachers’ professional competencies through peer review. In particular, the focus was on two different but interconnected activities: a) a direct internship supervised by a tutor; and b) an indirect internship supported by a mentor. Qualitative data were collected through semi-structured interviews with ten expert teachers and were analyzed using a grounded theory approach. Results show a wide proposal of features that characterize a good tutor and mentor in accompanying novice teachers’ growth. Secondly, the collected data provided an important contribution in that they helped identify the most important and useful activities (referring to the direct and indirect internships) for the development of competencies in future support teachers.
Pengaruh Resiliensi terhadap Psychological Well-Being dengan Dukungan Sosial sebagai Variabel Mediator pada Mahasiswa
Authors: Novianti Lili Dwi , Alfian Ilham Nur
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh resiliensi terhadap psychological well-being dengan dukungan sosial sebagai variabel mediator pada mahasiswa. Topik ini sebagai salah satu yang sering dibicarakan ketika peralihan masa dalam perkuliahan, stress akademik, tugas yang harus diselesaikan sehingga mahasiswa harus tetap resilien dan mencapai psychological well-being dengan adanya dukungan sosial dari teman, keluarga dan significant other. Data diperoleh dengan metode survei dan menggunakan skala Psychological Well-Being Flourishing Scale 8 item (α= 0,842), The Resilience Scales 14 item (α= 0,930), dan The Multidimensional Scale of Perceived Social Support 12 item (α= 0,760). Analisis dengan uji regresi sederhana dan teknik bootstrapping sebagai uji mediasi. Berdasarkan teknik bootstrapping menunjukkan bahwa terdapat pengaruh mediasi dukungan sosial dalam pengaruh resiliensi terhadap psychological well-being. Ditunjukkan bahwa dukungan sosial menjelaskan 25% dari total effect sehingga tergolong partial mediation. Hasil penelitian menunjukkan adanya pengaruh resiliensi terhadap psychological well-being dengan dimediasi oleh dukungan sosial dan jenis mediasi bersifat parsial.
Model-based assessment of shallow landslides susceptibility at a petrochemical site in Brazil
Authors: Cabral Victor Carvalho , Reis Fábio Augusto Gomes Vieira , Mendoza Carolina Martinez , Oliveira Alan
Published: April 2022

The Serra do Mar mountain range is the main site of shallow-landslides occurrence in Brazil. The application of physically-based models is an effective method to predict landslide susceptibility, which is of great importance in hazard assessments and urban-planning studies. Thus, the objective of this study is to compare landslide susceptibility scenarios created with SHALSTAB and SINMAP at two large watersheds (Mogi and Perequê) in Cubatão, Latin America’s largest petrochemical site. Model calibration is based on the landslide scars inventory of the 1985 event, the geotechnical parameters derived from soil samples and the topography sourced from a 5 m resolution DEM. Using the Receiver Operating Characteristics (ROC) analysis to assess model performance, SHALSTAB emerges as the best-fit model for both watersheds due to higher concentration of landslide scars in unstable areas (true positive results) and higher global accuracy. Even though SINMAP had similar degree of success, it was slightly less accurate and failed more often in the identification of potentially unstable areas. Comparative performance studies of physically-based models are fundamental to support effective and reliable hazard assessments in mountain regions, providing an outlook in how to proceed with more detailed studies.
Programa pedagógico “Cre-Acción” para estimular la sensibilidad intercultural en los estudiantes de la carrera de educación primaria de una universidad privada de Lima
Authors:   ,   Universidad San Ignacio de Loyola, Zavala Ollague Maria Elvira
Published: April 2022

La investigación propone el diseño de un programa pedagógico denominado “Creacción” con el fin de estimular la sensibilidad intercultural en los estudiantes de educación primaria de una universidad de Lima. Esta se enmarca en el paradigma sociocrítico, y el enfoque holístico; es una investigación educacional del tipo aplicada, el diseño es no experimental de corte transversal descriptivo. Se emplea el muestreo no probabilístico con una muestra conformada por dos docentes y 45 estudiantes universitarios(as). Entre las técnicas está la entrevista semiestructurada a docentes, la encuesta de opinión a los estudiantes y el análisis documental. El diagnóstico evidencia que la formación de los(las) estudiantes carece de competencias interculturales, incluyendo el aspecto afectivo/sensible, pese a que la mayoría procede de familias migrantes; la práctica de los(las) docentes acerca de la interculturalidad se basa en experiencias vivenciales y estrategias indirectas de enseñanza, algunas de las cuales expresan una visión parcial con influencias eurocentristas. El marco teórico sustenta las perspectivas de la interculturalidad y su reflejo en la educación, cuyo camino conduce hacia una pedagogía descolonizadora que ratifica la urgencia de desarrollar las competencias interculturales y la sensibilidad intercultural. Así, la alternativa está en diseñar un programa basado en el arte, con diferentes estrategias dramáticas como los juegos dramáticos, improvisaciones, títeres y dramatizaciones para promover la expresión, concienciación, creación y representación de situaciones interculturales. Se concluye que el estudio presenta una propuesta didáctica consistente, alineada a la sensibilización intercultural que favorece una intervención pedagógica en un contexto sociocultural, caracterizado por la diversidad y la multiculturalidad.
Pengaruh Ujian Akhir Semester Terhadap Hasil Belajar Siswa Kelas XI Mata Pelajaran Geografi Di SMA Negeri 1 Gelumbang
Authors: Sakinah Sakinah , Selegi Susanti Faipri
Published: April 2022

In the world of education the term evaluation is very important because one of the competencies that must be mastered by the teacher is the evaluation of learning. One form of assessment in the learning process is a summative test that can be a determinant of the process of student learning outcomes, but in the field of evaluation and assessment there are many shortcomings in its application so researchers are interested in researching about the Evaluation of Sumative Tests on Student Learning Outcomes. This research was conducted at the State High School 1 Gelumbang using quantitative methods. Data obtained from the documentation and distribution of questionnaires to students of class XI IPS with a population of 90 people but taken as many as 60 people using random sampling techniques. The results of this study were analyzed using the hypothesis test and homogeneity test to obtain the results of this study in the form of t-count ≥ t-table (13,529> 1,995) Then it can be concluded that there is a significant influence between summative evaluation with student learning outcomes by 73%, while the remaining 27% is influenced by another factor.
Peran Pemerintah Kota Banjarmasin dalam Pengelolaan Lingkungan Hilir Sungai Barito – Kalimantan Selatan
Authors: Alviawati Eva , Angriani Parida
Published: April 2022

Pengelolaan sungai memelukan sinergitas dari berbagai pihak. Pengelolaan sungai juga harus berkelanjutan dan dilakukan mulai dari hulu sampai ke hilir. Pemerintah dan masyarakat perlu saling bahu membahu dalam upaya pengelolaan sungai. Penelitian ini bertujuan untuk menganalisis peran pemerintah dalam pengelolaan lingkungan dan kondisi masyarakat hilir Sungai Barito. Metode yang dipergunakan dalam penelitian ini adalah kualitatif deskriptif. Data dalam penelitian ini berdasarkan hasil observasi lapangan dan pemanfataan data sekunder. Analisis data dilakukan secara deskriptif empirik. Hasil penelitian menunjukkan kegiatan pengelolaan sungai yang dilakukan oleh pemerintah antara lain melalui program perbaikan sungai seperti inventarisasi ulang dan labelisasi sungai, normalisasi sungai besar dan kecil, pembangunan dan pemeliharaan saluran drainase, revitalisasi dan penataan bantaran sungai, serta membangun fasilitas pendukung sungai lainnya. Selain pengelolaan secara fisik, program perbaikan sungai juga dilakukan pada aspek sosial ekonomi dan budaya masyarakat sekitar sungai, seperti melalui program PLPBK dan KOTAKU Kata Kunci: pengelolaan sungai, peran pemerintah, Sungai Barito
SATLabel: A Framework for Sentiment and Aspect Terms Based Automatic Topic Labeling
Authors: Shahriar Khandaker Tayef , Moni Mohammad Ali , Hoque Mohammed Moshiul , Islam Muhammad Nazrul , Sarker Iqbal H.
Published: April 2022

In this paper, we present a framework that automatically labels Latent Dirichlet Allocation (LDA) generated topics using sentiment and aspect terms from COVID-19 tweets to help the end-users by minimizing the cognitive overhead of identifying key topics labels. Social media platforms especially Twitter are considered as one of the most influential sources of information for providing public opinion related to a critical situation like the COVID-19 pandemic. LDA is a popular topic modelling algorithm that extracts hidden themes of documents without assigning a specific label. Thus automatic labelling of LDA-generated topics from COVID-19 tweets is a great challenge instead of following the manual labelling approach to get an overview of wider public opinion. To overcome this problem, in this paper, we propose a framework named \texttt{SATLabel} that effectively identifies significant topic labels using \textit{top unigrams features of sentiment terms and aspect terms clusters from LDA generated topics} of COVID-19 related tweets to uncover various issues related to the COVID-19 pandemic. The experimental results show that our methodology is more effective, simpler, and traces better topic labels compare to the manual topic labelling approach.
Face Spoof Attack Detection using Deep Background Subtraction
Authors: Benlamoudi Azeddine , Bekhouche Salah Eddine , Korichi Maarouf , Bensid Khaled , Ouahabi Abdeldjalil , Hadid Abdenour , Taleb-Ahmed Abdelmalik
Published: April 2022

Currently, face recognition technologies are the most widely used methods for verifying 1an individual’s identity. Nevertheless, it has increased in popularity, raising concerns about face spoofing attacks, in which a photo or video of an authorized person’s face is used to get access to services. Based on a combination of Background Subtraction (BS) and Convolutional Neural Networks (CNN), as well as an ensemble of classifiers, we propose an efficient and more robust face spoof detection algorithm. This algorithm includes a Fully Connected (FC) classifier with a Majority Vote (MV) algorithm, which uses different face spoof attacks (e.g., printed photo and replayed video). By including a majority vote to determine whether the input video is genuine or not, the proposed method significantly enhances the performance of the Face Anti-Spoofing (FAS) system. For evaluation, we considered the MSU MFSD, REPLAY-ATTACK, and CASIA-FASD databases. The obtained results by our proposed approach are better than those obtained by state of the art methods. On the REPLAY-ATTACK database, we were able to attain a Half Total Error Rate (HTER) of 0.62% and an Equal Error Rate (EER) of 0.58%. It was possible to attain an EER of 0% on both the CASIA-FASD and the MSU FAS databases.
Analysis of the Response and Efforts of The Government of Vietnam in Tackling COVID-19
Authors: Rosy Afifah Fidina , Melania Chantika Wuragil Budhi , Yuvanti Dita Aprilia
Published: April 2022

COVID-19 pandemic is considered a big challenge for every country in the world. This pandemic has had a significant impact on both the public health sector and the economic sector. As a country directly contiguous to China, Vietnam is one of the countries affected by the virus's spread. Even so, Vietnam can be categorized as a country recognized as successful in stemming this pandemic's spread. It can be seen from the absence of cases of death caused by COVID-19. Therefore, this paper is written to analyze the government of Vietnam's steps to successfully handle this pandemic and how government conditions can affect the success rate. The results obtained are, the success to tackle the COVID-19 is highly influenced by the background of the political system and governance in Vietnam and the existence of good coordination between government institutions. Moreover, the success factors are also influenced by the efforts taken throughout time to improve public services quality
The Impact of the One China Policy on Indonesia's Diplomatic Relations with Taiwan
Authors: Wahyudi Sava Anisha
Published: April 2022

The One China Policy or commonly referred to as the One China Policy is China's policy which states that no more Chin countries may be recognized other than their own. In this case, another country referred to by China is Taiwan, which also claims to be a country that has original power over mainland China and claims to be an independent country, not under the control of the People's Republic of China. Indonesia is one of the countries that implements the implementation of the One China Policy so that it has a fairly large impact on diplomatic relations or cooperation between Indonesia and Taiwan.
Un testimonio manuscrito de la primera edición del Corpus islamológico de Theodor Bibliander
Authors: González Muñoz Fernando
Published: April 2022

El manuscrito Basel, Universitätsbibliothek A XIII 25 consiste en una suerte de borrador para la impresión de varias secciones del Corpus islamológico de Johannes Oporinus y Theodor Bibliander: Machumetis Saracenorum principis eiusque successorum vitae ac doctrina ipseque Alcoran, que fue publicado a inicios de 1543 en Basilea y reimpreso en 1550. Este estudio pretende destacar el interés de este documento, pues, por una parte, permite deja ver algunos aspectos del proceso editorial: correcciones, supresiones, errores de imprenta etc; por otra, aporta algunos textos ajenos al corpus, como son una lista fragmentaria de títulos latinos para las suras del Corán y una versión manuscrita del tratado de Theodor Bibliander:  Ad nominis Christiani socios consultatio.
Gil, Juan, Scriptores Muzarabici saeculi VIII-XI, «Corpus Christianorum. Continuatio Medieavalis» 2 vols. (Turnhout: Brepols, 2020), 1469 pp. isbn: 978-2-503-58931-2.
Authors: Mellado Rodríguez Joaquín
Published: April 2022

Nota bibliográfica de la última edición de la obra.
High-Detail Fault Segmentation: Deep Insight into the Anatomy of the 1983 Borah Peak Earthquake Rupture Zone (Mw 6.9, Idaho, USA)
Authors: Bello Simone , Andrenacci Carlo , Cirillo Daniele , Scott Chelsea P. , Brozzetti Francesco , Arrowsmith J Ramon , Lavecchia Giusy
Published: April 2022

Following observations made in a survey campaign along the Lost River Fault (Idaho, USA) in 2019, we integrate both original and previously published data to obtain a detailed segmentation of the fault sections that failed in the 1983 Borah Peak earthquake (Mw 6.9). The earthquake ruptured the topographic surface with an oblique-normal faulting mechanism, activating two SW-dipping fault segments (Thousand Springs and Warm Springs) and a branching SSW-dipping fault (Arentson Gulch Fault) and producing coseismic surface ruptures with up to 3 m of vertical separation. We augment the 1983 earthquake description by interpreting high-resolution topography and fault mapping. We use quality vertical separation data, rupture zone width measurements, and fault slip data to analyze major and minor structural-geometric complexities, highlighting a partition of the deformation and a fault segmentation into four detail levels (i.e., segments, sections, subsections, and sectors). Our work provides new details of the 1983 Borah Peak earthquake, constraints for paleoseismic and seismotectonic studies, and a methodological approach applicable in other areas of the world. Our fault-slip data show variations along fault-strike that we interpret as kinematic partitioning. In 1983, the main southern segment had a large rupture zone width, while the northern segment localized the deformation. The distributed ruptures accommodate a large portion of the rupture length (~19.5 km versus 31 km for the main rupture) and displacement (~66%). 83% of the surface faulting and 80% of the displacement are located at the hanging wall of the main rupture. There is a strong correlation between vertical separation, rupture zone width, rupture position (footwall or hanging wall), and fault geometry. We highlight the control of the obliquity and kinematic partitioning in the surface expression of the earthquake propagation. We interpret the coseismic (i.e., 1983) and long-term (i.e., Quaternary) behavior, showing that the two activated segments had similar cumulated behaviors in distributing the deformation between synthetic and antithetic ruptures, despite the different geometries. Our results have implications for fault rupture behavior with application to rupture hazard.
El rol del ocultamiento de conocimiento en la relación entre estilos de toma de decisiones y el desempeño innovador
Authors: Chacón-Henao Juliana , Arias-Pérez José
Published: April 2022

El estilo de toma de decisiones que se adopta en una organización puede ser crucial para determinar su éxito al innovar, con miras a obtener una ventaja competitiva en el mercado. Sin embargo, se presentan obstáculos que debilitan la capacidad de la organización para innovar. Obstáculos como, por ejemplo, el ocultamiento del conocimiento dentro de las organizaciones. El ocultamiento del conocimiento se refiere al intento intencional de ocultar o retener el conocimiento que es solicitado por otra persona y se manifiesta en tres dimensiones: hacerse el bobo, ser evasivo y ser racional. Bajo esta premisa, este estudio analiza el efecto moderador del ocultamiento del conocimiento en la relación entre los estilos de toma de decisiones intuitivo y racional, y el desempeño innovador. El modelo de investigación se testeó en una muestra de empresas colombianas mediante ecuaciones estructurales. En cuanto a los hallazgos, se encontró que solo la toma de decisiones del estilo racional influye positivamente en el desempeño innovador de forma directa y que esta relación sorpresivamente es moderada positivamente por el ocultamiento racionalizado, una de las tres formas de ocultamiento del conocimiento. Los hallazgos son relevantes para abrir el camino a las investigaciones sobre ocultamiento del conocimiento en Colombia y Latinoamérica.
Escenarios probabilísticos del sector de la televisión abierta de cobertura local en el Ecuador
Authors: Arias-Chávez David Alejandro , Abril-Ortega Johana Elizabeth
Published: April 2022

Esta investigación radica en la aplicación de la prospectiva estratégica en el sector privado de canales de televisión local de señal abierta en Ecuador, con el objetivo de determinar los escenarios probabilísticos futuros, posibles y probables, luego de la aplicación de la Ley Orgánica de Comunicación en el país. La metodología utilizada es cuantitativa y cualitativa, dentro del tipo de estudio correlacional, ya que se evalúa y mide cada una de las variables. Así mismo, el estudio tiene la característica del diseño no experimental, con una clasificación longitudinal de tendencia, de tal forma que el método se basa desde la parte lógica y desde el proceso investigativo. Se delimitó a veintiocho empresas del segmento, localizadas en nueves zonas de planificación. Por tanto, se determinaron 63 variables y 37 stakeholders en función de los métodos MICMAC y MACTOR; con el SMIC Prob Expert se obtuvieron 64 escenarios probabilísticos, de los cuales el evento tendencial mantiene la más alta probabilidad de ocurrencia de 56,5 % y es desfavorable, porque ninguna variable clave puede ser alcanzada producto del impacto de esta ley. Por esta razón, se tendrán retos transcendentales que solventar en el futuro, los cuales pueden hallar más complicaciones por el descenso del nivel de liquidez del sector y un aumento en su nivel de endeudamiento, dado las inversiones en el largo plazo que los empresarios deben realizar.
A Rare Complication of Closed Loop Obstruction With Mesenteric Volvulus Due to Jejunal Diverticulosis – A Case Report
Authors: Samy Angeline Mary , Subramaniyan Sree , Jain Ankit
Published: April 2022

Jejunal diverticulosis is a rare condition seen in 1-2% of the population and is asymptomatic in 80% of its patients. It can however rarely produce life threatening complications such as perforation, bleeding and obstruction. Diagnosis is often delayed in such patients causing high mortality. We report a 79 year old gentleman presenting with intestinal obstruction for 2 days with peritoneal signs. CT revealed jejunal dilatation with twisting of mesentery with whirlpool sign and closed loop obstruction of jejunum. A differential diagnosis of Jejunal diverticulosis should be considered when encountering patients in the elderly age group in an emergency setting.
Clinical value of serum CA125, CA724, HE4, premenopausal and postmenopausal ROMA index for diagnosis of high-grade serous ovarian cancer
Authors: Hu Deyu , Qian Jun , Yin Fenghua , Wei Bing , Hu Weiping , Wang Jiayu , Yang Haiou
Published: April 2022

Background: This study aimed at exploring a panel of novel biomarker for early detection of high-grade serous ovarian cancer (HGSOC). Methods: The serum levels of CA125, CA724 and HE4 were compared among serum samples collected from patients with HGSOC, borderline malignancy or benign gynecologic pathologies. Univariable and multivariable logistic regression analyses were performed to identify the risk factors of HGSOC. Nomogram was established for predicting HGSOC using the risk factors. Receiver operating characteristic (ROC) curves was plotted and the area under the curve (AUC), sensitivity and specificity of the CA125, CA724, HE4, ROMA and new panel were calculated.Results: The serum concentration of CA125, CA724 and HE4 were increased among patients with HGSOC. The AUC of CA125, CA724, HE4, ROMA2 and the new panel based on age, CA125 and ROMA2 were 0.732 (0.646-0.818), 0.773 (0.699-0.847), 0.886 (0.831-0.941), 0.835 (0.763-0.907), and 0.933 (0.896-0.969), respectively. Nomogram was constructed to diagnose HGSOC based on CA125, age and ROMA2. The C-indices of this nomogram was 0.88 (95% CI= 0.81-0.95) in training cohort and 0.91 (95% CI= 0.86-0.96) in the validation cohort. The sensitivity and specificity were 89.66% and 82.44% in diagnosing HGSOC, and the positive predictive value and negative predictive value of new algorithm were 69.33% and 94.74%, respectively.Conclusion: The new index based on age, CA125 and ROMA2 could be a new auxiliary diagnostic indicator in distinguishing HGSOC from borderline malignancy.
Nrf2 regulates microglia-mediated phagocytosis and neuroinflammation after intracerebral hemorrhage
Authors: Liu Lirong , Bao Shuangjin , Yao Zhenjia , Bai Qinqin , Liang Chuntian , Fu Pengcheng , Liu Xiangyu , Zhang John H. , Wang gaiqing
Published: April 2022

Activated microglia is essential for hematoma clearance and recovery after intracerebral hemorrhage (ICH). This study aims to evaluate the effect of microglial functional transformation in hematoma clearance after ICH. Through in vitro and in vivo experiments, we also investigate whether Nuclear factor erythroid 2-related factor 2 (Nrf2) -mediated microglial phagocytosis and inflammatory response plays a role in hematoma clearance and functional recovery after ICH. In vitro experiments, BV-2 cells were cultured and randomly divided into 4 groups, including normal control, microglia + Nrf2-siRNA (100 nmol/L), microglia + monascin (15 µM), and microglia + Xuezhikang (200 µg/mL) groups. In vivo experiments, 42 mice were divided into 2 groups, i.e., sham, ICH+vehicle, ICH+Nrf2-/-, ICH+monascin (10mg/kg/day, twice) and ICH+ Xuezhikang (0.2g/kg/day, twice) groups. Further, neurologic scores, hemoglobin levels, microglial phagocytosis, brain expression of CD80/Trem1/TNF-α (pro-inflammatory cytokines), and CD206/Trem2/ BDNF(anti-inflammatory cytokines) were analyzed 72 hours after surgery. The results showed that Nrf2 agonists improved neurological deficits and decreased hemoglobin levels after ICH through regulating microglial functional transformation. Administration of Nrf2 agonist- monascin/ Xuezhikang improved microglia-mediated phagocytosis of erythrocytes and bio-particles through Nrf2 upregulation. Alternatively, monascin/ Xuezhikang promoted the expression of Triggering receptor II expressed on myeloid cells(Trem2), CD206, and BDNF while inhibiting the expression of Trem1,CD80, and TNF-α in microglia. Conversely, Nrf2 inhibition (Nrf2 siRNA or Nrf2-/-) demonstrated conflicting results after ICH. Microglial functional transformations are implicated in hematoma clearance after ICH. Nrf2 activation leads to microglial functional transformation and phagocytic responses then exert its neuroprotection after ICH. Nrf2 activator (Monascin /Xuezhikang) improves hematoma clearance and alleviates neuroinflammation by regulating microglial functional alteration after ICH.
Arabinogalactan prevented APAP-induced acute liver injury by regulating the intestinal flora in mice
Authors: Wang Dongxu , Zhou Shengxue , Wang Xiuying
Published: April 2022

Background: This study aimed to explore the mechanism by which arabinogalactan (AG) inhibited N-acetyl-para-aminophenol (APAP)-induced acute liver injury in mice. The balance of the mouse intestinal flora and the relationship between AG treatment and the PI3K/AKT and NF-κB signaling pathways were evaluated to confirm a liver-gut interaction. Methods: Mice were administered 2 different doses of AG (150 or 300 mg/kg body weight) by gavage for 7 days and liver injury was induced by a single injection of APAP (250 m/kg). Hematoxylin-eosin staining, terminal deoxynucleotidyl transferase dUTP nick-end labeling, and Hoechst 33258 fluorescence staining of liver tissue were used to analyze liver damage. Western blots were used to evaluate expression of proteins related to PI3K/AKT and NF-κB signaling pathways, and changes in the hierarchical structure of the intestinal flora were determined. Results: AG pretreatment increased the proportion of Lactobacillus and decreased the abundance of species from norank_o_Clostridiaceae and Prevotella in mouse feces compared with APAP-only treated mice. AG pretreatment reversed glutathione depletion and CYP2E1 overexpression, reduced the production of malondialdehyde and 4-hydroxynonenal, and decreased the levels of alanine aminotransferase, aspartate aminotransferase, tumor necrosis factor-α and interleukin-1β compared with the APAP-only treated mice. The levels of proteins related to the PI3K/AKT signaling pathway were similar between the AG and control groups. AG pretreatment significantly reduced APAP-induced hepatocyte apoptosis and necrosis and inflammatory infiltration into the liver. Conclusion: PI3K/AKT pathway-mediated BAX expression and the NF-κB signaling cascade were inhibited by AG. AG protected the intestinal flora composition, which subsequently suppressed oxidative stress in the liver, improved the inflammatory response, and reduced hepatocyte apoptosis and necrosis.
Organisation, influence, and impact of patient advisory boards in rehabilitation institutions - an explorative cross-sectional study.
Authors: Sagen Joachim , Børøsund Elin , Simonsen Ann Elisabeth , Habberstad Andreas , Kjeken Ingvild , Dagfinrud Hanne Solveig , Moe Rikke Helene
Published: April 2022

Background: Patient participation is highlighted as an important facilitator for patient-centered care. Patient participation organised as patient advisory boards (PABs) is an integral part of health care institutions in Norway. More knowledge is needed on how PAB representatives experience patient engagement (PE) with regard to organisation, influence, and impact.Objectives: The objective of this study was to describe how PAB representatives engage in PABs with regard to tasks, roles, influence, and impact on decision-making processes and service delivery.Methods: PAB representatives recruited from rehabilitation institutions completed the Norwegian version of the generic Public and Patient Engagement evaluation tool (Norwegian abbreviation EBNOR). EBNOR is tested for reliability and validity with good results and comprises 35 items within four main domains, policies and practices, participatory culture, collaboration, and influence and impact that provide responses about PE-levels. Categorical data were summarized using frequencies and percentages, and response categories were collapsed into three PE-levels: barrier, intermediate, and facilitating level. Free-text responses were analysed according to principles of manifest content analysis, summed up, and used to elaborate the results of the scores.Results: Of the 150 contacted PAB representatives, 47 (32%) consented to participate. The results showed that approximately 75% agreed that the organisation as a whole was strengthened as a result of patient participation. Four out of five main domains were scored indicating a facilitating level; policies and practices (53%), participatory culture (53%), collaboration and common purpose (37%), and final thoughts (63%). The scores in the domain influence and impact were in the intermediate PE-level (44%). Of a total of 34 codes from free text analyses, barriers to PE were coded 26 times, and PE facilitators coded 8 times.Conclusions: The findings indicate that most PAB representatives are satisfied with how rehabilitation institutions organise their PAB, but they still experience their impact as limited.
The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis
Authors: Yin WeiWei , Huang Chang-Chang , Chen Yi-Ru , Yu Dan-Qing , Jin Min , Feng Chun
Published: April 2022

Objective: The study aims to address whether serum anti-müllerian hormone (AMH) levels fluctuate in the short term after medication application, including oral contraceptives (OCs), metformin, GnRH analogues (GnRH-a), dehydroepiandrosterone (DHEA), vitamin D (VD), clomiphene citrate (CC), and letrozole.Methods: Published literature from PubMed, Embase, and Cochrane central was retrieved up until 19 September 2021. A total of 51 self-control studies with an average Newcastle-Ottawa quality assessment scale (NOS) score of 6.90 were analyzed. Data collection and analysis: the extracted data were entered into Stata software, and the weighted mean difference/standardized mean difference (WMD/SMD) and 95% confidence interval (CI) were used for data analysis.Results: After OCs treatment the AMH level showed a significant decline in women with normal ovarian function, which was significant within 3 months (WMD=-1.43, 95% CI: -2.05 to -0.80, P<0.00001). After metformin treatment the serum AMH decreased in polycystic ovary syndrome (PCOS) patients (WMD=-1.79, 95% CI: -2.32 to -1.26, P<0.00001), in both obese and non-obese patients. GnRH-a treatment in endometriosis patients led to dynamic changes in the serum AMH levels. that is, ascent at 1 month(P=0.05), and descent at 3 months (P=0.02). After DHEA treatment the serum AMH increased in diminished ovarian reserve (DOR) / poor ovarian response (POR) patients (WMD=0.18, 95% CI: 0.09 to 0.27, P<0.0001). After VD treatment the serum AMH increased, and it was obvious in non-PCOS patients (WMD=0.78, 95% CI: 0.34 to 1.21, P=0.0004). After CC treatment the serum AMH decreased significantly in PCOS patients, specifically in non-obese patients (WMD=-1.24, 95% CI: -1.87 to -0.61, P=0.0001). Conclusions: Serum AMH levels may be affected in the short term after drug application. Specifically, OC, metformin and CC leads to decreased AMH level, DHEA and VD leads to increased AMH level, and GnRH-a leads to dynamic variation, which is correlated with PCOS, obesity, age, and duration of medication. The impacts of these medication should be taken into consideration when AMH is used as a marker of ovarian reserve.
Probing the solar coronal magnetic field with physics-informed neural networks
Authors: Jarolim Robert , Thalmann Julia , Veronig Astrid , Podladchikova Tatiana
Published: April 2022

While the photospheric magnetic field of our Sun is routinely measured, its extent into the upper atmosphere remains elusive.
We present a novel approach for coronal magnetic field extrapolation, using a neural network that integrates observational data and the physical force-free magnetic field model. Our method flexibly finds a trade-off between the observation and force-free magnetic field assumption, improving the understanding of the connection between the observation and the underlying physics.
We utilize meta-learning concepts to simulate the evolution of active region NOAA 11158. Our simulation of 5 days of observations at full cadence, requires less than 13 hours of total computation time, enabling real-time force-free magnetic field extrapolations.
A systematic comparison of the time evolution of free magnetic energy and magnetic helicity in the coronal volume, as well as comparison to EUV observations demonstrates the validity of our approach. The obtained temporal and spatial depletion of free magnetic energy unambiguously relates to the observed flare activity.
Assessment of aquifer geometry and groundwater storage using three-dimensional hydrostratigraphic modeling and geophysical survey: The case study of Nefza massive dunes (Northern Tunisia)
Authors: Jerbi Hamza , Sebai Amal , Hamlaoui Ikram , Hamdi Mohamed , Hmida Nesrine
Published: April 2022

The aquifer system of Nefza in northern Tunisia has been exploited for decades in its southern part to meet the increasing need for drinking water. The drop in groundwater levels observed since the 1980s in this exploited area has led water resource managers to focus on the depletion of the groundwater resource, while the availability of groundwater in the entire aquifer system is not well known. To date, the total amount of groundwater stored in the aquifer system has never been fully estimated. That is the purpose of this paper. The methodology includes (1) creating a comprehensive database combining all available lithological and geophysical data (2) designing a three-dimensional model of the aquifer system (3) incorporating hydrodynamic parameters into the model to estimate groundwater storage. The developed model illustrates the spatial distribution of groundwater storage, improves mapping of aquifer geometry, and delineates major aquifers and aquitards. Over 45 km2 of the modeled area, the calculated groundwater storage in 2019 was approximately 3 × 109 m3 with a highly variable spatial distribution. It was found that the area currently exploited for drinking water supply represents low groundwater storage between 97 and 377 m3/voxel (voxel size =1000 m x 1000 m x 5 m) while the unexploited area has excellent groundwater storage up to 798 m3/voxel. Furthermore, over the past 52 years (1976-2019), only 0.2% of the groundwater storage in the aquifer has been depleted. This paper suggests that water management challenges should focus on accessing non-exploited areas of the aquifer covered by forests, even though the cost of the land development and the installation of water pipelines is burdensome. In addition, the water balance of the aquifer is poorly known and groundwater flow in this region needs to be better assessed by multiple methods such as geochemistry and hydrodynamic modeling.
Research on a novel and improved incremental conductance method
Authors: Sun Chunhu , Ling Jing , Wang Jing
Published: April 2022

Aiming at the unsatisfactory effect of MPP tracking when the light intensity changes rapidly, a novel and improved incremental conductance method is proposed based on the study of PV battery output characteristics and incremental conductance method of photovoltaic power generation system. The paper firstly introduces the photovoltaic power generation system; secondly, it analyzes and studies the traditional incremental conductance method and summarizes its shortcomings; then, according to the shortcomings of the traditional incremental conductance method, a novel and improved method is proposed. Incremental conductance method, divided and analyzed the four sections of the I-U characteristic curve and designed the variable-step incremental conductance method; finally, built the simulation of the traditional incremental conductance method and the improved incremental conductance method in the Matlab/Simulink environment The two algorithms are compared and simulated under the condition of rapid change of light intensity. The simulation results show that when the light intensity changes rapidly, the novel improved incremental conductance method not only has the advantages of no oscillation in steady state and fast response speed, but also can make the system output more power and improve the efficiency of photovoltaic power generation , which better realizes the fast and accurate tracking of MPP.
TCERG1L hypermethylation is a risk factor of diabetic retinopathy in Chinese children with type 1 diabetes
Authors: Jin Peiyao , Qian Yu , Xiao Ying , Lin Qiurong , Xiang Zhaoyu , Cui Lipu , Sun Jiaqi , Li Sicong , Qin Xinran , Yang Chenhao , Zou Haidong
Published: April 2022

Background: To identify the differential methylation sites (DMS) and their according genes associated with diabetic retinopathy (DR) development in type 1 diabetes (T1DM) children. Methods/Results: This study consists of two surveys. 40 T1DM children with no DR participated in the first survey. Their DNA methylation status was assessed by the Illumina methylation 850K array BeadChip assay. Comparison of the methylation patterns was made between participants with macular retinal thinning (cases) and the others (controls). The second survey included 27 T1DM children, among which 4 had DR. Pyrosequencing was used to validate the results of the 850K array, and the methylation patterns of four DMS was compared between participants with and without DR.In the first survey, the 850K array revealed 751 sites significantly and differentially methylated in the case group comparing with the controls (|Δβ|> 0.1 and Adj.P-value <0.05), while 328 of these were identified with a significance of Adj.P<0.01. Among these, 319 CpG sites were hypermethylated and 432 were hypometh­ylated in the case group relative to the controls. Four of the identified DMS with a potential role in diabetes were chosen to be validated in the second survey. Pyrosequencing revealed that the TCERG1L (cg07684215) gene was hypermethylated in the four T1DM children with DR (p=0.018), which was consistent with the result from the first survey. The methylation status of PDXK, PARK2 and PPARG showed no difference (all p>0.05) between participants with and without DR.Conclusions: The hypermethylation of the TCERG1L gene is a risk factor for DR development in Chinese children with T1DM.
Evidence of plasma lunar tide in the Earth-Moon system
Authors: Xiao Chao , He Fei , Shi Quanqi , Liu Wenlong , Tian Anmin , Guo Ruilong , Yue C. , Zhou Xu-Zhi , Wei Yong , Rae Ian , William Degeling Alexander , Angelopoulos Vassilis , Masongsong Emmanuel , Liu Ji , Zong Qiu-Gang , Fu Suiyan , Pu Zuyin , Zhang Xiaoxin , Wang Tieyan , Wang Huizi , Zhang Zhao
Published: April 2022

Tides are universal, significantly affecting spatially distributed systems, from planetary to galactic scales. In the Earth-Moon system, lunar tides have been studied in the solid Earth, liquid ocean, and neutral gas-dominated atmosphere (including the ionosphere). However, whether a lunar tide effect exists over wider plasma dominated regions has remained unexplored until now. Here we show direct evidence of a lunar tide signal in the plasmasphere, a typical cold “plasma ocean” in the Earth-Moon space, by analyzing variations in its boundary location over the past four decades from multi-satellite observations. This signal possesses distinct diurnal (and monthly) periodicities, surprisingly different from the semidiurnal (and semimonthly) variations dominant in the atmosphere, ocean, and solid Earth, with tidal surface perturbations of up to ~800 km via disturbing the electric field. These results demonstrate the importance of lunar tidal effects in plasma dominated regions of Earth-moon space, opening new perspectives for understanding Moon-atmosphere-magnetosphere coupling process through gravity and electromagnetic forces, and has implications for tidal interactions in other two-body celestial systems.
Polymerization of the backbone of the pectic polysaccharide rhamnogalacturonan I
Authors: Amos Robert , Atmodjo Melani , Huang Chin , Gao Zhongwei , Venkat Aarya , Taujale Rahil , Kannan Natarajan , Moremen Kelley , Mohnen Debra
Published: April 2022

Rhamnogalacturonan I (RG-I) is a major plant cell wall pectic polysaccharide defined by its repeating disaccharide backbone structure of [4)-α-d-GalA-(1,2)-α-l-Rha-(1,]. A family of RG-I:Rhamnosyltransferases (RRT) has previously been identified, but synthesis of the RG-I backbone has not been demonstrated in vitro because the identity of Rhamnogalacturonan I:Galaturonosyltransferase (RG-I:GalAT) was unknown. Here, a putative glycosyltransferase, At1g28240/MUCI70, is shown to be an RG-I:GalAT. The name RGGAT1 is proposed to reflect the catalytic activity of this enzyme. When incubated together with the rhamnosyltransferase RRT4, the combined activities of RGGAT1 and RRT4 result in elongation of RG-I acceptors in vitro into polymeric product. RGGAT1 is a member of a new GT family categorized as GTx that is phylogenetically distinct from the GALACTURONOSYLTRANSFERASE (GAUT) family of GalA transferases that synthesize the backbone of the pectin homogalacturonan (HG). RGGAT1 has a predicted GT-A fold structure, but employs a metal-independent catalytic mechanism that is rare among glycosyltransferases with this fold type, suggesting that RG-I biosynthesis has functionally diverged from the mechanisms used for synthesis of HG and other plant cell wall polysaccharides.