bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic effective stress analysis of a centreline tailings dam under subduction earthquakes
Authors: Macedo Jorge , Torres Paola , Vergaray Luis , Paihua Solange , Arnold Cody
Published: February 2022

A case study was conducted to evaluate the seismic performance of a centreline tailings dam in the South American Andes through dynamic effective stress analyses with advanced constitutive models. The seismic demand at the dam site was evaluated through a probabilistic seismic hazard assessment (PSHA), from which deterministic and probabilistic-based seismic design criteria were derived. The PSHA results were used to select spectrally matched ground motions for the subsequent dynamic analyses. The plan is for the centreline tailings dam to be raised in stages to a height of 90 m; this was considered in establishing the initial stresses and pore pressures before seismic loading. The material properties were based on a large geotechnical characterisation programme considering the mine tailings to be stored in the deposit and other critical dam components. Dynamic analyses were performed using the UBCHYST constitutive model for materials that are not expected to generate significant excess pore pressures and the PM4Silt constitutive model for materials that may generate excess pore pressures due to cyclic loading. The results showed the deformation patterns in the centreline dam, after seismic loading, to be significantly affected by the presence of mine tailings. The results of this work will be useful in planning the overall operational management of the tailings facility.
Chimeric Fusion between Clostridium Ramosum IgA Protease and IgG Fc Provides Long-Lasting Clearance of IgA Deposits in Mouse Models of IgA Nephropathy
Authors: Xie Xinfang , Li Jingyi , Liu Pan , Wang Manliu , Gao Li , Wan Feng , Lv Jicheng , Zhang Hong , Jin Jing
Published: February 2022

Significance Statement

IgA nephropathy is the most common glomerulonephritis worldwide and a leading cause of kidney failure. The disease often progresses through episodes of flare-ups that require effective treatments to tame inflammation. We followed a rational design strategy to construct a recombinant fusion IgA protease derived from commensal gut microbiota Clostridium ramosum. The fusion protease, referred to as Fc-AK183, showed week-long activity in mice to completely obliterate IgA in circulation and clear pathologic deposits in the kidney. Therefore, the recombinant enzyme is a promising drug candidate for future treatment of IgA nephropathy.

Background

IgA nephropathy is a common primary glomerulonephritis caused by mesangial deposition of poly-IgA complexes. The disease follows a variable course of clinical progression, with a high risk of kidney failure. Although no specific therapy is available, enzymatic strategies to clear IgA deposits are being considered for the treatment of rapidly progressive IgA nephropathy.

Methods

We chose an IgA protease of commensal bacterium Clostridium ramosum, termed AK183, as the template for constructing a recombinant biologic. To extend the t
1/2 in blood, we fused AK183 to the Fc segment of human IgG1. Activities of this Fc-AK183 fusion protein toward the cleavage and subsequent clearance of IgA were tested in mouse models.

Results

First, we discovered an autocleavage activity of AK183 that separates the N-terminal protease from its C-terminal autotransporter β domain. Therefore, we grafted Fc to the N terminus of AK183 and demonstrated its week-long enzymatic activity in mice. In addition, the proteolytic fragments of IgA generated in the reaction with Fc-AK183 were effectively removed from circulation via kidney filtration. The combined actions of Fc-AK183-mediated cleavage and subsequent renal clearance of IgA resulted in a lasting obliteration of blood IgA, as demonstrated in a human IgA-injection model and in a humanized α1KI transgenic model. Fc-AK183 was also able to remove chronic IgA and associated complement C3 deposits in the glomerulus.

Conclusion

We constructed a chimeric fusion of IgA protease with Fc and demonstrated its long-lasting efficacy as a promising targeted therapy for IgA nephropathy in mouse models.
A new sexually dimorphic species of the genus Oribatella (Acari, Oribatida, Oribatellidae) from Russia
Authors: Ermilov Sergey G. , Khaustov Alexander A. , Joharchi Omid , Döker Ismail , Khaustov Vladimir A.
Published: February 2022

A new oribatid mite species of the genus Oribatella (Oribatida, Oribatellidae)—Oribatella altaica Ermilov sp. n. – is described from soil-litter in Altai mountains, Russia; it is showing an interesting sexual dimorphism in the structure of the posterior part of notogaster (large unpaired concavity bearing a pair of porose areas A3 present in males versus concavity absent, A3 located openly on notogastral surface in females). In addition, data on the known sexually dimorphic Oribatella species are presented.
Praxiswerbung für Videosprechstunden in der Telearbeitsmedizin
Authors:   Medizinische Hochschule Hannover, Betriebsärztlicher Dienst, Albrecht Urs-Vito , Pramann Oliver ,   Kanzlei34- Rechtsanwälte und Notare, Hannover
Published: February 2022

Telearbeitsmedizin wird bereits von einigen Firmen und Praxen erfolgreich eingesetzt. Mit einem Teleangebot wie der “Videosprechstunde” ließe sich insbesondere unter der Corona-Situation gut werben. Doch inwiefern werden hierdurch die engen Grenzen des Heilmittelwerbegesetztes übertreten und welche Konsequenzen kann das nach sich ziehen?
COVID-19 und SARS-CoV-2 im Arbeitsschutzrecht
Authors: Aligbe Patrick
Published: February 2022

Das Geschehen rund um COVID-19 und das dieser Erkrankung zugrunde liegende Coronavirus (SARS-CoV-2) hat auch massive Auswirkungen auf das Arbeitsleben und muss somit im Arbeitsschutzrecht besonders berücksichtigt werden. Im Gegensatz zum Infektionsschutzrecht (das im Jahr 2020 mehrfach angepasst wurde) hielt der Gesetzgeber allerdings im Wesentlichen die bestehenden Regelungen des Arbeitsschutzrechts für ausreichend, um der Infektionsgefährdung durch SARS-CoV-2 Rechnung zu tragen.
Zehn Thesen zur Situation von Studierenden in Deutschland während der SARS- CoV-2-Pandemie
Authors:   Institut für Arbeits-, Sozialund Umweltmedizin Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Dietz Pavel
Published: February 2022

Der folgende Beitrag präsentiert zehn Thesen zu den Auswirkungen der SARS-CoV-2-Pandemie und den damit einhergehenden Veränderungen des studentischen Lebens. Sie sollen als Diskussionsgrundlage dienen und den unterschiedlichen Handlungsakteuren Erkenntnisse zur Situation der Studierenden und ihrer Unterstützung während der Pandemie liefern.
SARS-CoV-2-Testung von Beschäftigten des bremischen Öffentlichen Dienstes
Authors:   Performa Nord, Zentrum für Gesunde Arbeit, Bremen, Neumann Jan , Zeeb Hajo ,   Leibniz-Institut für Präventionsforschung und Epidemiologie – BIPS, Bremen, Dotzauer Andreas ,   Laboratorium für Virusforschung, Universität Bremen
Published: February 2022

Innerhalb des bremischen öffentlichen Dienstes wird für bestimmte Personengruppen eine SARS-CoV-2-Testmöglichkeit mit der Maßgabe einer zeitnahen Ergebnisrückmeldung vorgehalten. Um dieses während der Feiertage des Jahreswechsels 2020/21 zu gewährleisten, wurden parallel zu den sonst etablierten konventionellen Nukleinsäureamplifikation-Verfahren (RT-PCR) für einen begrenzten Zeitraum auch SARS-CoV-2-Antigen-Schnelltests durchgeführt. Diese Studie diente der Ermittlung der unterschiedlichen Testcharakteristiken, insbesondere der Sensitivitäten, und wurde nach einem positiven Votum der Ethik-Kommission der Ärztekammer Bremen (Vorlage-Nr.: 747) als monozentrische, nicht-interventionelle epidemiologische Studie in das Deutsche Register Klinischer Studien aufgenommen (DRKS-ID: DRKS00023878).
Aspekte mobil-flexibler Arbeit
Authors:   Bereich Arbeitsmedizin, Medizinische Fakultät Otto-von-Guericke-Universität Magdeburg, Bölsch-Peterka Ronja , Böckelmann Irina ,   Bereich Arbeitsmedizin, Medizinische Fakultät Otto-von-Guericke-Universität Magdeburg
Published: February 2022

Aspects of mobile and flexible working Professional mobility and flexibility are in themselves not a phenomenon that only emerged through the change in the world of work. It is characteristic of today that professional mobility is demanded by more and more companies and thus more employees are affected. It extends to other professions and is not only relevant for mobile occupations, such as professional drivers. In addition to the positive aspects of mobile work for employees (such as freedom, design options), there is also evidence of negative aspects. There is already some awareness of the health implications of various aspects of this form of work. However, there is little awareness of the health implications of the combined forms of mobile-flexible work (multimobility). Keywords: mobile and flexible working – mobility skills – change in the world of work – health-promoting working conditions
Arbeitsschutzverordnung zu elektromagnetischen Feldern
Authors:   Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (BAuA), Dortmund, Jeschke Peter , Alteköster Carsten ,   Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA), Sankt Augustin
Published: February 2022

Der Arbeitsschutz in Bezug auf elektromagnetische Felder (EMF) ist bereits seit 2001 durch eine berufsgenossenschaftliche Vorschrift der Deutschen Gesetzlichen Unfallversicherung geregelt. Seit 2016 ist die staatliche Arbeitsschutzverordnung zu EMF (EMFV) gültig, die die Europäische Arbeitsschutzrichtlinie zu EMF in nationales Recht umsetzt. Dieser Beitrag beschreibt die Anwendungen und anerkannten Wirkungen von EMF und legt dar, wie die EMFV den Schutz von Beschäftigten vor möglichen Gefährdungen durch EMF gewährleistet.
Corona-Wunschvorsorge via Telefon und Online- Videosprechstunde
Authors:   Institut für Lehrergesundheit am Institut für Arbeits-, Sozial- und Umweltmedizin der Universitätsmedizin Mainz, Kegel Peter , Becker Jan ,   Institut für Lehrergesundheit am Institut für Arbeits-, Sozial- und Umweltmedizin der Universitätsmedizin Mainz, Dahlke Eva ,   Institut für Lehrergesundheit am Institut für Arbeits-, Sozial- und Umweltmedizin der Universitätsmedizin Mainz, Rose Dirk-Matthias ,   Institut für Lehrergesundheit am Institut für Arbeits-, Sozial- und Umweltmedizin der Universitätsmedizin Mainz, Letzel Stephan ,   Institut für Lehrergesundheit am Institut für Arbeits-, Sozial- und Umweltmedizin der Universitätsmedizin Mainz
Published: February 2022

Elective coronavirus preventive care via telephone and online video consultation Objective: The Institute for Teacher Health offers elective coronavirus preventive care in the context of the SARS-CoV-2 pandemic. This article describes the data and the accompanying evaluation of the online video consultation. Recommendations for practical use are derived from the data and the experience gained. Method: The elective preventive care was provided (optionally by telephone or online video consultation) based on a standardized process taking into account medical findings, medical history and work history. In addition to the medical history, the consultation also included advice on hygiene and infection control in the workplace. A case conference decided on the individual need for protection. Sociodemographic and medical data were analyzed descriptively and inferentially. Online video consultation was evaluated. Results: During the evaluation period (03/08/2020 – 30/11/2020), data were available from n = 357 individuals (51.8 % via online video consultation, 45.9 % via telephone). 27.4 % were classified as requiring superior protection, 35.3 % as possibly requiring special protection and 37.3 % as not particularly requiring superior protection. The most common relevant diagnoses for high risk were rheumatoid arthritis/polyarthritis, chronic inflammatory bowel disease and diabetes mellitus. Satisfaction with the online video consultation was high. Conclusion: The newly developed standardized procedure for elective coronavirus preventive care has proved to be a viable solution for advising employees in need of protection concerning infection control and hygiene and assessing the risk of their employment in schools. The online video consultation was well received. However, technical hurdles must be taken into account on the part of both the occupational health advisors and the employees seeking advice. Keywords: teachers – SARS-CoV-2 – requested prevention – pandemic – telemedicine
Förderung der mentalen Fitness für eine alternde Belegschaft
Authors:   Institut für Arbeiten Lernen Altern (ALA), Bochum, Falkenstein Michael , Kardys Claudia ,   FOM Hochschule Essen
Published: February 2022

Moderne Arbeit benötigt Beschäftige mit hoher mentaler Fitness, die allerdings im Lauf des Lebens oft nachlässt. Dies ist weniger durch das Altern als durch Umwelt- und Lebensstilfaktoren bedingt, so dass betriebliche Maßnahmen an beiden Aspekten ansetzen sollten.
Sozialmedizinische Entwicklungen bei der Erwerbsminderungsrente
Authors:   Deutsche Rentenversicherung Nordbayern, Würzburg, Berger Harald
Published: February 2022

In der gesetzlichen Rentenversicherung gibt es nicht nur rechtliche Entwicklungen wie zum Beispiel die vieldiskutierte Grundrente. Auch aus medizinischer Sicht gibt es bei der Erwerbsminderungsrente und dem Zugang in diese Rente neue Erkenntnisse beziehungsweise Veränderungen, mit denen sich sozialmedizinisch tätige Ärztinnen und Ärzte mit dem vordringlichen Ziel des Erhalts der Erwerbsfähigkeit befassen.
Individuelle Corona-Strategien im Tätigkeitsfeld eines überbetrieblichen Betriebsarztes
Authors:   Pneumologische Facharztpraxis Dr. med. Rainer Schädlich, Weinz Christof
Published: February 2022

Das SARS-CoV-2-Virus prägt seit einem Jahr nicht nur die Diskussionen in der medizinischen Fachwelt, sondern auch das öffentliche Leben und in besonderem Maße die Arbeitswelt. Als überbetrieblicher Teilzeit-Betriebsarzt, der zur anderen Hälfte in einer fachärztlichpneumologischen Praxis angestellt ist, hat der Autor hierbei auf sehr unterschiedliche Ansprüche der verschiedenen Betriebe flexibel einzugehen. Die zu berücksichtigenden Aspekte sind in Arztpraxen, ambulanten Pflegediensten, logopädischen oder physiotherapeutischen Praxen anders als im produzierenden Gewerbe, der Lebensmittelindustrie oder der öffentlichen Verwaltung.
SARS-CoV-2-bedingter Impact auf die Psyche von Beschäftigten
Authors:   Organisationsberatung MDO, Landeshauptstadt Mainz, Gaalken Klaus
Published: February 2022

Der Gesundheitsschutz zur Verhinderung einer SARS-CoV-2-Infektion der Beschäftigten steht in der kommunalen Verwaltung der Landeshauptstadt Mainz derzeit an oberster Stelle. Zugleich stellt die SARS-CoV-2-bedingte Pandemie einen massiven Belastungs-Impact auf bewährte Handlungsroutinen der Arbeit mit mehrdimensionalen Folgen für die Arbeitsfähigkeit, die Motivation und die Psyche von Beschäftigten dar.
Patientenlifter zur Belastungsminderung des Pflegepersonals
Authors:   Sachverständigenbüro, Millstatt, Landau Kurt
Published: February 2022

Beschwerden und Erkrankungen im Bereich der Lendenwirbelsäule verdienen bei der Belastungsanalyse von Pflegetätigkeiten, insbesondere von Transfervorgängen, besondere Beachtung. Eine Metastudie von 27 Artikeln kommt zum Ergebnis, dass bei den n = 13.317 berichteten Fällen bei den Pflegekräften eine Prävalenz von etwa 72% für arbeitsbedingte Muskel-Skelett-Erkrankungen bestand (Ellapen u. Narsigan 2014). Patientenlifter können zur Belastungsminderung beitragen, allerdings werden sie aus verschiedenen Gründen sowohl im Krankenhaus als auch im Altenpflegeheim nicht oder nicht korrekt eingesetzt.
Mutterschutz bei Bleiexposition
Authors:   Institut für Arbeits-, Sozial- und Umweltmedizin, LMU Klinikum München, Ochmann Uta
Published: February 2022

Über das Mutterschutzgesetz soll die Gesundheit von Schwangeren und deren ungeborener Kinder am Arbeitsplatz geschützt werden. Während für Erwachsene bei Einhaltung des aktuellen biologischen Grenzwerts (BGW) von 150 μg/l Blut keine gesundheitliche Gefährdung zu erwarten ist, sollten die Blutbleiwerte mit Beginn einer Schwangerschaft im Referenzbereich der Allgemeinbevölkerung liegen, da aufgrund der Neurotoxizität von Blei bei höheren Werten eine Schädigung von Gehirn und Nervensystem des ungeborenen Kindes möglich ist. Somit müssen bereits im Vorfeld von Schwangerschaften, also im Sinne eines präventiven Mutterschutzes, individuelle Lösungen gefunden werden.
Grenzwertevaluierung von Blei
Authors:   Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin der FAU Erlangen-Nürnberg, Drexler Hans , Hartwig Andrea ,   Karlsruher Institut für Technologie (KIT), Abteilung Lebensmittelchemie und Toxikologie, Karlsruhe
Published: February 2022

Wegen der eingeschränkten Reisetätigkeit während der COVID-19-Pandemie wurden Arbeitsgruppensitzungen der MAK-Kommission zur Ableitung von Grenzwerten und Einstufungen für Blei und seine anorganischen Verbindungen auf digitalem Weg durchgeführt. Die Videokonferenzen ermöglichten es den Mitgliedern der Kommission, punktuell und stoffspezifisch an Arbeitsgruppensitzungen teilzunehmen und Blei mit seiner umfangreichen Datenlage vertieft zu diskutieren. In nur sechs Monaten wurden der BAT-Wert von 150 μg Blei/l Vollblut, der MAK-Wert von 4 μg Blei/m³ sowie sechs Einstufungen wissenschaftlich evaluiert und verabschiedet, ohne dass Abstriche in der wissenschaftlichen Gründlichkeit akzeptiert worden wären.
Infraschall aus technischen Anlagen. Wissenschaftliche Grundlagen für eine Bewertung gesundheitlicher Risiken
Authors:   Institut für Pharmazie, Universität Halle-Wittenberg, Roos Werner , Vahl Christian ,   Klinik und Poliklinik für Herz- und Gefäßchirurgie, Universitätsmedizin Mainz
Published: February 2022

Infrasound from technical installations: Scientific basis for an assessment of health risks Background: The pathogenic potential of infrasound from technical sources is significantly underestimated by the public and politicians. Wind turbines are the most common emitters and their rapid rollout means that an increasing number of residents are affected by far reaching pressure pulses. Methods: Research findings relating to causal mechanisms of infrasound are compiled and examined for indications of adverse effects on health. Results: Infrasound is perceived as a stressor and is met with adaptive and defensive responses. Points of attack for toxic effects can be identified a) at cellular level, where membrane processes react with particular sensitivity. This leads to disruption of the microcirculation, muscle contraction and neuronal signal transmission. b) In the cardiovascular system, the effects mentioned in a) cause a reduction in the efficiency of the myocardial muscle coupled with centrally mediated bradycardia, hypertension and reduced cardiac output. c) The signal receptors for the balance system receive infrasound as interference and produce a clinical picture similar to motion sickness. d) In the brain, infrasound is unconsciously perceived in areas that are involved in the control of autonomic functions (incl. respiratory frequency and blood pressure) and in emotional control. Conclusions: The findings available today substantiate a fundamental health risk for people exposed to infrasound. The steep pressure pulses of actual emissions have been disregarded by government-initiated studies of wind turbines to date. There is a need for adequate safety margins and further research in order to establish dose (energy)-response curves for the cardinal symptoms. Keywords: infrasound – wind turbine – pressure pulse – adverse effects on health
Impfungen im betrieblichen Setting
Authors:   Institut für Lehrergesundheit am Institut für Arbeits-, Sozial- und Umweltmedizin Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Diehl Elisabeth , Bogner Kathrin ,   Institut für Lehrergesundheit am Institut für Arbeits-, Sozial- und Umweltmedizin Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Rose Dirk-Matthias ,   Institut für Lehrergesundheit am Institut für Arbeits-, Sozial- und Umweltmedizin Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Schneider Michael ,   Boehringer Ingelheim
Published: February 2022

Aufklärung, Information und Organisation sind das A und O um die Inanspruchnahme von Schutzimpfungen zum allgemeinen Bevölkerungsschutz/Infektionsschutz im betrieblichen Setting zu erhöhen. Dies zeigen die Ergebnisse einer Querschnittsbefragung bei dem Unternehmen Boehringer Ingelheim Pharma GmbH & Co. KG, die im Rahmen einer Studie zur Influenza-Impfung erhoben wurden.
Arbeitsmedizinische Vorsorge zu Blei
Authors:   Institut für Arbeits-, Sozial- und Umweltmedizin, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Letzel Stephan
Published: February 2022

In der aktuellen Fassung der Verordnung zur arbeitsmedizinischen Vorsorge gilt als Auslöseschwelle für die Pflichtvorsorge bei Tätigkeiten mit einer Exposition gegenüber Blei und seinen anorganischen Verbindungen ein Luftgrenzwert von 75 μg/m3. Da dieser Wert nicht gesundheitsbasiert ist, kann bei dessen Einhaltung eine Gesundheitsgefährdung von Beschäftigten mit einer entsprechenden Exposition nicht sicher ausgeschlossen werden. Der Ausschuss für Arbeitsmedizin (AfAMed) diskutiert daher aktuell, wie die Auslöseschwelle für Tätigkeiten mit einer Exposition gegenüber Blei angepasst werden kann.
ProZES – Neue Software zu Strahlenexposition und Krebs
Authors:   Bundesamt für Strahlenschutz, Oberschleißheim, Schnelzer Maria , Heinzl Felix ,   Bundesamt für Strahlenschutz, Oberschleißheim, Scholz-Kreisel Peter ,   Bundesamt für Strahlenschutz, Oberschleißheim
Published: February 2022

War jemand im Beruf gegenüber ionisierender Strahlung exponiert und erkrankt später an Krebs, stellt sich die Frage, ob ein Zusammenhang zwischen der Erkrankung und der Strahlenexposition besteht. Das vor Kurzem vom Bundesamt für Strahlenschutz veröffentlichte Programm ProZES (Programm zur Berechnung der Zusammenhangswahrscheinlichkeit zwischen einer Erkrankung und einer Strahlenexposition) ist ein Hilfsmittel für die Beantwortung dieser Frage in konkreten Fällen. Dieser Beitrag stellt das Programm vor.
50 Jahre Gehörschadenprävention in der Schweiz
Authors:   Suva Arbeitsmedizin, Luzern, Meyer Anja
Published: February 2022

Prävention beruflicher Lärmschädigungen wird von der Schweizerischen Unfallversicherungsanstalt (Suva) seit fünfzig Jahren betrieben. Schweizweit sind Audiomobile im Einsatz, auf denen Gehöruntersuchungen, Dämmmessungen von Gehörschutzmitteln und Lärmschutzberatungen stattfinden. Im Wandel der Zeit wurden ehemalige Konzepte modernisiert und der Digitalisierung zugänglich gemacht. Trotz großer Verbesserungen der technischen und medizinischen Gehörschadenprävention während fünf Jahrzehnten bleibt die Anzahl gemeldeter Fälle von Lärmschädigungen aus verschiedenen Gründen auf hohem Niveau.
Globale Erderwärmung. Mit welchen Auswirkungen auf den Arbeitsplatz ist zu rechnen?
Authors:   Unisanté, Epalinges-Lausanne, Schweiz, Vernez David , Backes Caudine ,   Unisanté, Epalinges-Lausanne, Schweiz
Published: February 2022

Die globale Erderwärmung steht vor der Tür: Hitzewellen, Hitzestress (und somit körperliche Wärmebelastung), erschwerte Arbeitsbedingungen: Was erwartet Arbeitskräfte im Freien zukünftig?
Belastungsreduktion im Rettungsdienst: Ausgewählte Hilfsmittel in den Einsatzmitteln des bodengebundenen Rettungsdienstes
Authors:   Stadt Leipzig, Dezernat III, Branddirektion, Abteilung Rettungsdienst, Plöthner Marika , Schröder Ralph ,   Stadt Leipzig, Dezernat III, Branddirektion, Abteilung Rettungsdienst
Published: February 2022

Strain reduction in rescue service: Selected devices in the resources of ground ambulances Aims: Increasing numbers of deployments and a high workload are characteristic of prehospital care. The use of technical devices may reduce the strain on employees and help to improve workplace ergonomics. This literature analysis illustrates the benefits of selected devices so that recommendations can be derived for designing and equipping ground ambulances in the future. Methods: In May 2020, a device-specific systematic literature search was conducted by using the literature database PubMed. The aim was to identify articles with the following outcomes: physical stress, accidents, critical events, injuries, incapacity for work and patient outcome. Results: 22 studies were included in the final review. The majority of studies evaluated electro-hydraulic stretchers (n = 14), followed by automated chest compression devices (n = 4), rollboards (n = 3) and two-backpack system (n = 1). No studies on ECG monitors, respiratory devices or electric stair climbers could be identified with regard to the outcomes observed at the time of examination. Conclusion: Decisions on the implementation of new devices should always be based on evidence. This review shows significant benefits for patients and employees by using the devices considered. An ergonomic ambulance design leads to an increase in patient safety as well as to a reduction in strain for employees. Keywords: ergonomics – emergency services – technical devices – prehospital care
Hautschutzmaßnahmen der sekundären und tertiären Individualprävention (SIP/TIP)
Authors:   Berufsdermatologie, Universitätshautklinik, Heidelberg, Weseloh Christiane , Weisshaar Elke ,   Berufsdermatologie, Universitätshautklinik, Heidelberg
Published: February 2022

Berufsbedingte Hautkrankheiten zählen vor allem in den Industrienationen zu den häufigsten Berufskrankheiten (BK). Meistens sind die Hände in Form eines Kontaktekzems betroffen. Dem individuellen Hautschutz kommt daher eine wichtige Rolle zu, um die Haut gesund zu erhalten. Geeignete Hautschutzmaßnahmen müssen von den Betroffenen erlernt und trainiert werden, nicht zuletzt, um auch einer Chronifizierung des Krankheitsbildes und damit verbundenen Folgekosten vorzubeugen.
Hautschutz in Pflegeberufen – Herausforderungen und Lösungen
Authors:   Institut für interdisziplinäre Dermatologische Prävention und Rehabilitation (iDerm) an der Universität Osnabrück, Sonsmann Flora Karla , Skudlik Christoph ,   Institut für interdisziplinäre Dermatologische Prävention und Rehabilitation (iDerm) an der Universität Osnabrück, Wilke Annika ,   Institut für interdisziplinäre Dermatologische Prävention und Rehabilitation (iDerm) an der Universität Osnabrück
Published: February 2022

Bedingt durch den hohen Umfang an Feuchtarbeit zählen Pflegeberufe zu den Hautrisikoberufen. Aufgrund der SARS-CoV-2-Pandemie haben die Hautbelastungen durch eine weitere Intensivierung der Hygiene- und Schutzmaßnahmen, zum Beispiel durch das zusätzliche konsequente Tragen eines Mund-Nasen-Schutzes, bei den pflegerisch Beschäftigten zugenommen. Dieser Artikel fokussiert die Auswahl, richtige Umsetzung, Anwendung und Implementierung von Hautschutzmaßnahmen im pflegerischen Kontext, um die Haut betroffener Personen auch unter den aktuellen Bedingungen möglichst gesund und damit die Arbeitskraft zu erhalten.
Revisión de investigaciones sobre escritura académica para la construcción de un centro de escritura digital en educación superior
Authors: Chaverra Fernández Dora Inés , Calle-Álvarez Gerzon Yair , Hurtado Vergara Rubén Darío , Bolívar Buriticá Wilson Antonio
Published: February 2022

Las investigaciones de naturaleza disciplinar o transdisciplinar centradas en el fortalecimiento de competencias para la escritura académico-científica en la educación superior presentan múltiples divergencias de orden teórico y metodológico, máxime cuando se incluyen variables relacionadas con la cultura académica y el uso de tecnologías digitales. Este artículo expone una revisión de estudios asociados a la escritura académica en la educación superior, que podría contribuir al diseño de un centro de escritura digital. La base documental está constituida por 58 textos, analizados con el lenguaje de programación Python 3.7®, utilizando principalmente la librería de lenguajes naturales (Natural Language Toolkit) y técnicas de análisis del discurso. Los resultados de dicha revisión evidencian la consolidación de dos líneas de investigación: a) los estudios sobre los componentes pedagógico-didácticos para la promoción de la escritura académica, y b) el fortalecimiento del aprendizaje de la lengua materna. Estos resultados sugieren que no hay convergencia entre postulados requeridos en el diseño, la fundamentación e implementación de estrategias experimentales para la construcción de un centro digital de escritura, como son: a) los epistemológicos, relacionados con las formas de construcción del conocimiento; b) los pedagógicos, asociados al propósito formativo de la escritura en la ciencia y la cultura, y c) los metodológicos, vinculados a la integración de la escritura con las tecnologías digitales.
Adherencia a la dieta sin gluten y calidad de vida de los celiacos del Paraguay, 2021
Authors: Real-Delor Raúl , Chamorro-Aguilera María Elena
Published: February 2022

Antecedentes: la calidad de vida en relación con la salud de las personas con enfermedad celiaca puede estar influenciada por la adherencia a la dieta sin gluten. Objetivos: describir las características demográficas y clínicas de los celiacos, evaluar la adherencia dietética con el cuestionario CDAT de Leffler y medir la calidad de vida autopercibida utilizando el cuestionario CD-QOL. Métodos y materiales: diseño observacional, transversal y  rospectivo. Se aplicó una encuesta telemática a adolescentes y adultos de Paraguay diagnosticados con enfermedad celiaca, entre febrero y abril del año 2021, que accedieron a participar del estudio. La adherencia dietética se determinó con el cuestionario Celiac Dietary Adherence Test de Leffler y la calidad de vida con el CD-QOL de Dorn. Se midieron además variables demográficas y clínicas. La investigación fue aprobada por el Comité de Ética de la Universidad Privada del Este, en Paraguay. Resultados: la muestra estuvo constituida por 344 sujetos de estudio, de los cuales el 87 % pertenecía al sexo femenino. La edad media de los adolescentes fue de 15,1 años, y la de los adultos de 38±13 años. La adherencia a la dieta sin gluten se encontró en el 78 % (n=268) de los encuestados; fue buena en el 59 %, moderada en el 19 % y mala en el 22 % de los encuestados. La calidad de vida fue buena en el 30 % (n=103) de los sujetos y mala en el 70 % (n=241). Se encontró asociación entre los sujetos sin o mala adherencia a la dieta con la mala calidad de vida (p<0,006). Conclusión: en los celiacos estudiados, la mala adherencia a la dieta sin gluten se asocia con menor calidad de vida en relación con la salud.
MODERN SPACE POLICY OF UKRAINE AND THE REALITY OF JOINING THE EUROPEAN SPACE AGENCY
Authors:   Scientific Research Institute of State Building and Local Government of National Academy of Law Sciences of Ukraine, Kostenko Inesa
Published: February 2022

Today, the question of the probability of Ukraine’s accession to the European Space Agency is becoming quite popular. However, can we observe a real basis for this? Or will it remain at the level of planning and discussion without further implementation? The State Space Agency of Ukraine, and the European Space Agency, are currently working on a roadmap to address this issue. Thus, in two or three years we will have a concrete procedure, and according to the current head of the State Space Agency of Ukraine, we will have the opportunity to join the European Space Agency. But, on the other hand, many reasons contradict the reality of such plans, namely: non-compliance of the State Space Agency of Ukraine with many criteria, inadequate level of legal regulation in space, imperfect and not updated under modern forms of government in space, etc. An action plan for Ukraine’s integration into the European Space Agency of Ukraine, aimed at implementing all components of European Space Agency membership, namely the following tasks: ensuring the negotiation process with European Space Agency to expand cooperation at this stage; building the image of Ukraine as an active partner of European Space Agency, the EU, and the Member States and associated with European Space Agency in the implementation of projects in the field of space activities; approximation of Ukrainian and EU legislation in the area of space activities and project implementation procedures; preparation for the conclusion of the Agreement of the state cooperating with European Space Agency; preparation for Ukraine’s membership in European Space Agency. Among the key priorities of long-term cooperation with European partners, experts highlight the cooperation in the field of Global Navigation Satellite System (GNSS) in the framework of the pan-European global navigation satellite system EGNOS/Galileo, in the field of global monitoring for security and environment, and in particular in within the GMES project, as well as in the field of remote sensing of the Earth (remote sensing). This paper will explore how real this is and how ready Ukraine is to join the European Space Agency. After all, Ukraine’s accession to European Space Agency will give impetus to the development of space science and technology in Ukraine, allow it to join leading European space missions, enable Ukrainian companies to participate in European Space Agency programs and projects, and Ukraine – to use the final products of these programs and projects.
HOW TO EVALUATE EFFICIENCY OF COOPERATION BETWEEN UKRAINE AND INTERNATIONAL ORGANIZATIONS ON REGIONAL DEVELOPMENT BASED ON THE "POLICY TRANSFER" APPROACH
Authors:   National Academy of Public Management under the President of Ukraine, Tkachenko Victoriia , Tkachenko Igor ,   Taras Shevchenko national University of Kyiv
Published: February 2022

The aim of the article is to represent the results of the authors' scientific findings on the adaption of widely known in foreign scientific thought approach of "policy transfer" for evaluation of cooperation's efficiency between Ukraine and international organizations on regional development. Authors find out that the specific of the "policy transfer" approach is its constructive character. Changes in the system of regional policy of Ukraine are continuous and the process of management is still ongoing. The framework of regional development in Ukraine is still corrected, updated and advanced not based on the internal domestic factors or election programs of political parties as in other countries, but throughout external influence led by international organizations such as EU, OECD and UNDP. Practical aim of the publication is to provide arguments for the hypotheses of "policy transfer" as an approach that may be practically used for researching and describing of essence, features, results and efficiency of cooperation between Ukraine and international organizations in the sphere of regional development. Authors synthesize conclusions on how to use the "policy transfer" approach for evaluating the efficiency of Ukraine's cooperation with international organizations on regional development by providing a comparative analysis of previously made research by E. Ertugal on policy transfer in regional development in Turkey.
The Concepts "Estándar", "Norma" and "Variedad" as a Reflection of Linguistic Variability in the Spanish Area
Authors: Murashkina O.V.
Published: February 2022

The dialectal diversity of the Spanish language creates certain difficulties in teaching Spanish as a foreign language due to the complex relationship between the standard, the norm and the national variant. Idiomatic variability manifests itself at all levels of the language: phonetic, phonological, morphological, syntactic. In our short message, attention is paid to the phonological level, which is the most difficult due to the dialect factor.
Accentuation of the Modern Sound of N.A. Nekrasov's Poetry in the Process of Independent Work of High School Students
Authors: Vydrina N.A.
Published: February 2022

The article offers tasks for organizing independent work of high school students on comprehension and emotional development of moral issues, language and style of Nekrasov's poetry from the standpoint of modernity.
The First Comprehensive Study of the Thanatological Discourse of Russian Literature
Authors: Sukina L.B.
Published: February 2022

The article is a review of the collective monograph "Thanatological Theme in Russian Literature of the 11th-21th centuries", prepared by well-known experts in the field of Russian literature V.A. Voropaev, I.V. Dergacheva, E.L. Konyavskaya and V.V. Milkov. The peer-reviewed book publishes the results of a comprehensive study of ideas about death and posthumous life based on data from Old Russian written monuments and the most significant works of Russian fiction of the 18th-21th centuries. According to the authors of the book, the basis of literary thanatology in Russian culture was the Christian doctrine. But it also absorbed elements of autochthonous pre-Christian views on the afterlife and external impulses that came in the process of intercultural communication with Byzantium and the countries of Europe.
FISHERY RESOURCE POTENTIAL OF MANIMALA RIVER OF KERALA, INDIA
Authors: Plamoottil Mathews , Suvarnakumar G.
Published: February 2022

Studies were conducted on abundance and diversity of ichthyofauna of Manimala River. Ninety seven fish species were collected from various locations of Manimala River. Species diversity, total number of species, fishery potential, percentage of different aspects of catches etc were taken into consideration.
EVALUATION OF GLUTATHIONE REDUCTASE (GR) ACTIVITY IN LIVER OF FISH, CHANNA PUNCTATUS (BLOCH, 1793) EXPOSED TO HEXAVALENT CHROMIUM
Authors: Awasthi and Sunil P. Trivedi Yashika
Published: February 2022

Antioxidant defence system is known to be a sensitive biomarker of metal exposure widely employed in predicting toxicity after sub-lethal exposure of Cr6+in fish. The present study conducted to assess the impact of Cr6+on Glutathione reductase (GR) activity in liver of fish, Channa punctatus. Fish were exposed to two different sub-lethal concentrations of Cr6+viz.,3.93 mg/L (5% of 96h LC50) (T1) and 7.85 mg/L (10% of 96h LC50) (T2) along with one control group without any toxicant exposure, for 15, 30 and 45 d. Results showa significant (p <0.05) increase in GR activity with an increase in dose and exposure period. This study emphasized the role of GR in monitoring of metal toxicity in aquatic regimes as an early warning tool.
ALTERATION OF BIOCHEMICAL PARAMETERS IN THE BREEDING CYCLE OF MYSTUS VITTATUS (BLOCH.) EXPOSED TO MUNICIPAL SEWAGE AT BASTI CITY (U.P.)
Authors: Tripurari Mishra Diwakar Ram Tripathi  and
Published: February 2022

Biochemical disorder in fishes are intimately associated with inclusive physiological hindrance. Many types of biochemical faults and deformity in the metabolism of carbohydrates, Proteins, fats and Nucleic acids are finding in different tissue of environmentally  tressed fishes. The responsibility of gonadial tissue i.e. testes and ovary are upgrade many times during the breeding phase of the reproductive cycle of teleost fishes. Any biochemical deformity in their tissues would adversely affect the reproductive activity of fish population. Fresh water pollution mainly of the Kuwano river is caused by runoff from house drains, street disposal, sewage and effluents from small and large scale of industries situated nearby the river. On spot observations indicate that heavy fish mortality has been occurring in the areas in the river Kuwano contaminated by municipal sewage. The examined biochemical parameters were glycogen, amino acids, and cholesterol. The acute toxicity and bioassays of sewage exposed to test fish Mystus vittatus has been conducted for its three breeding phases i.e. pre-spawning, spawning and post-spawning.
HAEMATOLOGICAL PROFILE OF FRESHWATER FISH, CHANNA STRIATUS (BLOCH) UNDER THE STRESS OF ZINC SULPHATE
Authors: G. Sunitha Devi P. Pandari Reddy and
Published: February 2022

In the present investigation, Zinc Sulphate toxicity was evaluated on various haematological parameters in a fresh water air-breathing fish, Channa striatus. When exposed to sublethal concentrations (15, 20 and 30mg/L) of Zinc Sulphate in water for a period of 10, 20, 30 and 40days. At the end of 10, 20, 30 and 40days exposure periods, blood samples were collect from the control and experimental fish. The fish blood was assayed for selected haematological parameters, Haemoglobin (Hb), Red blood cells (RBC), Haematocrit (Hct) and White blood cells (WBC). The derived haematological indices of Mean cell volume (MCV), Mean cell Haemoglobin (MCH) and Mean cell Haemoglobin concentration (MCHC) were calculated. The fish, showed a haematological response after exposure (10, 20, 30 and 40days) to 15, 20 and 30mg/L of Zinc Sulphate. There was a decrease in Haemoglobin content (Hb), Red blood cells (RBC), Haematocrit value (Hct) and Mean cell haemoglobin (MCH). A significant increase was observed in WBC and Mean cell volume, Mean cell haemoglobin concentration. In conclusion, the alterations were observed indicate that haematological parameters can be used as an indicator of Zinc related stress in fish on exposure to elevated Zinc Sulphate levels.
REGENERATION IN EUDRILUS EUGENIAE KINBERG 1867 (OLIGOCHAETA, ANNELIDA)
Authors: Anto Anu , Jomon Mary , Pavithran Neenu , Vasu Sruthy , Shaju Nimisha Nedumparambil
Published: February 2022

Earthworm EudriluseugeniaeKinberg 1867, commonly known as African night crawler is an efficient organic waste decomposer. As the dedifferentiation patterns of these invertebrates are like vertebrates, they are excellent candidates for regeneration studies. We made 12 amputations along the earthworm to demarcate anterior and posterior sections for regeneration studies. Regeneration events included wound healing, blastema formation, segmentation, pigmentation and functional clitellum formation. Clitellum formation was noted in the posterior segments after 28-30 days of amputation, whereas anterior segments without clitellum did not survive after 30days. In both anterior and posterior segments, number of segments remaining after amputation proved to be a significant factor in determining the survival rate. Earthworms with less than one fourth of the body length showed very low survival rates.But no significant correlation existed between the lengths of regenerating fragment and number of remaining segments in the amputated worms. Analysis of variance showed no significant difference between regeneration rates of different segments in anterior segments whereas the posterior segments showed significant difference in the regeneration rates.
COMPARATIVE ANALYSIS OF HYPOCHLORITE METHOD ON TRANSGENIC STRAIN BY250
Authors: Singh Neha , Gautam Priyanka
Published: February 2022

Caenorhabditis elegans is an ideal model organism that has been applied to a wide range of studies into toxicology, neurobiology, molecular, and developmental biology. C.elegans has gain popularity as a model system worldwide because of its availability of genome database and similarity of the genome to human have enlarged its applications in the different areas of research and to study the molecular mechanism of various human diseases such as neurodegenerative, metabolic, and so on. The researchers were synchronized C.elegans to larval stage L1 before they experimented. These studies were propagated and describe as a powerful tool to obtain a large population of worms through a synchronization process at a specific stage, which can be used for a variety of experiments.
Comorbidity Index as a Risk Factor of Knee PJI Recurrence After Spacer Implantation
Authors: Preobrazhensky Petr M. , Bozhkova Svetlana A. , Kazemirsky Alexander V.
Published: February 2022

Background. Patient-related risk factors for periprosthetic joint infection (PJI) are currently investigated in detail. However, the influence of those factors on PJI recurrence and their confounding effect was not investigated. Identifying factors that influence PJI recurrence and establishing the role of each risk factor are important.
The study aimed to analyze the comorbidity structure in patients with knee PJI and create, based on obtained data, a rating scale that allows predicting the probability of PJI recurrence after spacer implantation.
Methods. A single-center study was conducted based on retrospective data of 161 patients with PJI after primary total knee arthroplasty treated with staged reimplantation from January 2007 to January 2017. To clarify comorbidity structure and the most important risk factors, all patients were divided into two groups: patients with PJI recurrence after spacer implantation (group 1, n = 48) and patients who successfully passed spacer implantation (n = 113, group 2). Based on the obtained data, the frequency of comorbidities was analyzed. The list included 17 points that characterized the presence and severity of different comorbidities. Then, we conducted a logistic regression analysis to identify the significance of each factor and thresholds for the comorbidity index (CI) for the interpretation of the final score. With the presented scale, spacer implantation in the compared groups was analyzed.
Results. The most significant comorbidities were anemia, chronic kidney disease, obesity, and cardiovascular pathology. The CI thresholds were calculated, which allowed interpretation of the obtained score. The distribution of patients by risk categories within each group was also analyzed, and differences between groups were determined. The CI value corresponding to the minimal risk of PJI recurrence was more common (p0.0001) in group 1. Moreover, more than half of the patients with failed spacer implantation had a high risk of PJI recurrence according the CI value, and only 6.2% of patients who had successful treatment had CI high value (p0.0001).
Conclusions. The multivariate analysis of the presence and severity of concomitant pathologies enabled the development of a comorbidity scale with the calculation of an integral indicator (comorbidity index) and establishment of its threshold values. The proposed CI could be the basis for a combined relapse risk calculator and an algorithm for choosing the surgical treatment strategy in patients with knee PJI, which requires further investigation.