bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploration of the Socioecological Determinants of Hong Kong Workers’ Work-Life Balance: A Grounded Theory Model
Authors: Wong Ka Po , Chan Alan Hoi Shou
Published: October 2021

Background: Although a growing body of research has investigated the theoretical and empirical models of work-life balance (WLB), the propositions of this phenomenon remain nonunified. Thus, a grounded theory approach was adopted to explore the viewpoints of workers regarding WLB and its determinants and consequences. Methods: Individual face-to-face interviews were conducted to investigate the attitudes and experiences of Hong Kong workers towards WLB, in which 50 workers were interviewed. All data of interviews were transcribed verbatim and coded into five levels of the socioecological framework (i.e., intrapersonal level, interpersonal level, organisational level, community and government policy). Results: The grounded theory model established that work-life balance and personal context mutually affected each other, and work-life balance was unidirectionally affected by the environmental context. The ability to maintain a continual satisfied physical and mental states among multiple roles under the emergence of unexpected environmental factors was proposed as the definition of work-life balance. Conclusions: The findings of this study offer essential research insights into the importance of WLB, the dynamic features for workers to sustain balance and constructing a reliable and exhaustive assessment model for work-life balance for future studies.
Occupational Characteristics in the Outbreak of the COVID-19 Delta Variant in Nanjing, China: Rethinking the Occupational Health and Safety Vulnerability of Essential Workers
Authors: Liu Yujun , Yang Bowen , Liu Linping , Jilili Maitixirepu , Yang Anuo
Published: October 2021

The risk of contracting COVID-19 varies by occupation. Clarifying the occupational disparity in the infection risk is crucial to the prevention and control of the epidemic in the workplace. In late July, some new cases of COVID-19 were confirmed among cleaners working in Lukou International Airport in Nanjing, China. The infected cases rapidly increased and spread to many domestic cities in the following days. The present study traces the brief reports of epidemiological investigations among the confirmed cases released by the Nanjing government from 20 July to 2 August, and offers a descriptive analysis on the occupational distribution of these cases. Cleaners and other staff working in the airport were found to make up more than 40% of all cases. The overwhelming majority of the cleaner cases were confirmed in the first 7 days. The present study statistically ascertains that the airport cleaners were the initial sufferers and transmitters in this outbreak. They experienced occupational health and safety vulnerability on both individual and contextual levels, including workplace hazards, workplace safety policies, and lack of awareness and empowerment. Effective protection for essential workers and the strict surveillance of occupational health in the workplace is urgently needed.
Community Pharmacists’ Perceptions, Barriers, and Willingness for Offering Sexual and Reproductive Health Services
Authors: Alshahrani Ali Mofleh , Alsheikh Mona Y.
Published: October 2021

The role of community pharmacists is crucial for promoting health and providing consultation related to sexual and reproductive health. This study measured the perception of community pharmacists in the Kingdom of Saudi Arabia (KSA) towards the provision of counselling services on sex education and reproductive health, including barriers to and proficiency in the delivery of services. A cross-sectional survey was developed and distributed electronically to pharmacists, and responses were analyzed using SPSS version 26. Graphical representations for various opinions on perception, proficiency and barriers were created. More than 80% of pharmacists placed a high value on counselling patients on sex and reproductive health, about 90% counselled their patients very often (74.6%) or often (22.2%), and 3.2% of pharmacists did not counsel patients. Most respondents believed counselling was very important (65.3%) or important (15.1%), with only 19.6% of respondents indicating it was not important. Barriers to offering services included fear from responsibility and liability (M = 4.8), lack of information about patient health (M = 4.7), gender differences (M = 4.7), and lack of social acceptability (M = 4.6). Community pharmacists in KSA possessed positive attitudes, professional education, and willingness to provide counselling to patients on sex education and reproductive health. Apart from the existing barriers that require augmented community pharmacists’ soft skills, clear policies and authorization for offering this type of service are also needed.
Automatic Diagnosis of Mental Healthcare Information Actionability: Developing Binary Classifiers
Authors: Ji Meng , Xie Wenxiu , Huang Riliu , Qian Xiaobo
Published: October 2021

We aimed to develop a quantitative instrument to assist with the automatic evaluation of the actionability of mental healthcare information. We collected and classified two large sets of mental health information from certified mental health websites: generic and patient-specific mental healthcare information. We compared the performance of the optimised classifier with popular readability tools and non-optimised classifiers in predicting mental health information of high actionability for people with mental disorders. sensitivity of the classifier using both semantic and structural features as variables achieved statistically higher than that of the binary classifier using either semantic (p < 0.001) or structural features (p = 0.0010). The specificity of the optimized classifier was statistically higher than that of the classifier using structural variables (p = 0.002) and the classifier using semantic variables (p = 0.001). Differences in specificity between the full-variable classifier and the optimised classifier were statistically insignificant (p = 0.687). These findings suggest the optimised classifier using as few as 19 semantic-structural variables was the best-performing classifier. By combining insights of linguistics and statistical analyses, we effectively increased the interpretability and the diagnostic utility of the binary classifiers to guide the development, evaluation of the actionability and usability of mental healthcare information.
Working at Green Care Farms and Other Innovative Small-Scale Long-Term Dementia Care Facilities Requires Different Competencies of Care Staff
Authors: de Boer Bram , Buist Yvette , de Bruin Simone R. , Backhaus Ramona , Verbeek Hilde
Published: October 2021

The culture change movement within long-term care in which radical changes in the physical, social and organizational care environments are being implemented provides opportunities for the development of innovative long-term care facilities. The aim of this study was to investigate which competencies care staff working at green care farms and other innovative types of small-scale long-term dementia care facilities require, according to care staff themselves and managers, and how these competencies were different from those of care staff working in more traditional large-scale long-term dementia care facilities. A qualitative descriptive research design was used. Interviews were conducted with care staff (n = 19) and managers (n = 23) across a diverse range of long-term facilities. Thematic content analysis was used. Two competencies were mainly mentioned by participants working in green care farms: (1) being able to integrate activities for residents into daily practice, and (2) being able to undertake multiple responsibilities. Two other competencies for working in long-term dementia care in general were identified: (3) having good communication skills, and (4) being able to provide medical and direct care activities. This study found unique competencies at green care farms, showing that providing care in innovative long-term care facilities requires looking further than the physical environment and the design of a care facility; it is crucial to look at the role of care staff and the competencies they require.
The Effect of Urban Land-Use Change on Runoff Water Quality: A Case Study in Hangzhou City
Authors: Li Li , Yu Qidi , Gao Ling , Yu Bin , Lu Zhipeng
Published: October 2021

The main functions of this research are to guide the proportion of urban land that is used and the layout of the facilities on it, help understand the changes to surface runoff that are caused by land being used in urban development, and thus solve surface runoff pollution. Hangzhou City, China has been selected for the experiment, and the way in which its land is utilized as well as the grading of urban construction projects in the demonstration area are specifically analyzed. This study systematically distinguishes the definitions of impervious area based on the Sutherland equation and analyzes the impact of different impervious area subtypes on surface runoff water quality. Then, we compare the impact of impervious area subtypes with the impact of other land-use patterns on surface runoff water quality. This study shows the relationship between different land-use types and runoff water bodies: Land-use index can affect runoff water quality; Greening activities, impervious surface, and the water quality index are negatively correlated; the effective impervious area rate is positively correlated with the water quality index. The paper suggests that increasing the proportion of green spaces and permeable roads in build-up land reduces the effective impervious area (EIA) and thus controls land runoff pollution and improves runoff water quality.
Palliative Care Coverage across European National Health Systems: Proposal of a Synthetic Indicator
Authors: Sánchez-Cárdenas Miguel Antonio , Garralda Eduardo , Benítez Edgar , Arias-Casais Natalia , van Steijn Danny , Centeno Carlos
Published: October 2021

Background: The coverage of palliative care (PC) may be understood as a country’s capacity to offer prevention and relief from serious health-related suffering in relation to an existing need. The aim of this study is to estimate European countries´ coverage capacities. Method: Secondary analysis of three indicators, including the number of specialized services (SSPC), integration capacity scores (ICS) and the PC needs. By means of a K-medians clustering supervised algorithm, three coverage profiles were obtained: (1) Advanced: countries with high ICS and SSPC, and low PC needs; (2) Limited: countries with low ICS and SSPC, and low PC needs; and (3) Low: countries with low ICS and SSPC and high PC needs. Results: On average, the ratio of specialized services per population was 0.79 per 100,000 inhabitants, the average ICS was 19.62 and the average number of deceased patients with SHS per 100,000 inhabitants was 5.69. Twenty countries (41%) reached an advanced coverage profile. Nine countries (18%) demonstrated a limited coverage profile; and 20 countries (41%) fell under a low-coverage capacity. Conclusion: The level of palliative care coverage across Europe shows that 59% of European countries have either limited or very low availability of PC resources as regards their palliative care needs.
Trends in Airborne Chrysotile Asbestos Fibre Concentrations in Asbestos Cement Manufacturing Factories in Zimbabwe from 1996 to 2016
Authors: Mutetwa Benjamin , Moyo Dingani , Brouwer Derk
Published: October 2021

Zimbabwe has two major factories that have been manufacturing chrysotile asbestos cement products since the 1940s. Exposure monitoring of airborne fibres has been ongoing since the early 1990s. This study examines trends in personal exposure chrysotile asbestos fibre concentrations for the period 1996–2016. Close to 3000 historical personal exposure measurements extracted from paper records in the two factories were analysed for trends in exposure. Exposure over time was characterised according to three time periods and calendar years. Mean personal exposure chrysotile asbestos fibre concentrations generally showed a downward trend over the years in both factories. Exposure data showed that over the observed period 57% and 50% of mean personal exposure chrysotile asbestos fibre concentrations in the Harare and Bulawayo factories, respectively, were above the OEL, with overexposure being exhibited before 2008. Overall, personal exposure asbestos fibre concentrations in the factories dropped from 0.15 f/mL in 1996 to 0.05–0.06 f/mL in 2016—a decrease of 60–67%. These results can be used in future epidemiological studies, and in predicting the occurrence of asbestos-related diseases in Zimbabwe.
The Quality of Life of Children with Myelomeningocele: A Cross-Sectional Preliminary Study
Authors: Rozensztrauch Anna , Iwańska Magdalena , Bagłaj Maciej
Published: October 2021

Objectives: To investigate the relationship between the defects and symptoms caused by myelomeningocele (MMC) and quality of life. Design: A cross-sectional questionnaire survey. Methods: The subjects were 52 parents of children with MMC. Structured questionnaires were used: the Pediatric Quality of Life Inventory 4.0 Generic Core Scales (PedsQLTM 4.0) and a Study-Specific Questionnaire (SSQ). Results: The overall PedsQLTM 4.0 score was 56.4 (SD ± 14.7). A strong, significant negative correlation was found between the children’s age and emotional functioning. Functioning in this area deteriorated with age by a mean of 1.5 points per year of age. Children with no hydrocephalus functioned significantly better than those with this defect in the physical, social, and school areas (p < 0.05). Foot deformities significantly (p = 0.033) adversely affected the children’s physical functioning. Living in a single-parent family had no statistically significant impact on functioning in any of the areas analyzed (p > 0.05). Conclusion: Understanding the QoL of children with MMC and identifying its determinants may help in planning interventions to minimize the adverse impact of the illness.
Chromosome Aberrations in Lymphocytes of Patients Undergoing Radon Spa Therapy: An Explorative mFISH Study
Authors: Paz Nerea , Hartel Carola , Nasonova Elena , Donaubauer Anna-Jasmina , Frey Benjamin , Ritter Sylvia
Published: October 2021

In the present exploratory study, we aim to elucidate the action of radon in vivo and to assess the possible health risks. Chromosome aberrations were analyzed in lymphocytes of two patients (P1, P2) undergoing radon spa therapy in Bad Steben (Germany). Both patients, suffering from painful chronic degenerative disorders of the spine and joints, received nine baths (1.2 kBq/L at 34 °C) over a 3-week period. Chromosome aberrations were analyzed before and 6, 12 and 30 weeks after the start of therapy using the high-resolution multiplex fluorescence in situ hybridization (mFISH) technique. For comparison, the lymphocytes from two healthy donors (HD1, HD2) were examined. P1 had a higher baseline aberration frequency than P2 and both healthy donors (5.3 ± 1.3 vs. 2.0 ± 0.8, 1.4 ± 0.3 and 1.1 ± 0.1 aberrations/100 analyzed metaphases, respectively). Complex aberrations, biomarkers of densely ionizing radiation, were found in P1, P2 and HD1. Neither the aberration frequency nor the fraction of complex aberrations increased after radon spa treatment, i.e., based on biological dosimetry, no increased health risk was found. It is worth noting that a detailed breakpoint analysis revealed potentially clonal aberrations in both patients. Altogether, our data show pronounced inter-individual differences with respect to the number and types of aberrations, complicating the risk analysis of low doses such as those received during radon therapy.
Wearing a Surgical Face Mask Has Minimal Effect on Performance and Physiological Measures during High-Intensity Exercise in Youth Ice-Hockey Players: A Randomized Cross-Over Trial
Authors: Shaw Keely A. , Butcher Scotty , Ko Jong Bum , Absher Abdi , Gordon Julianne , Tkachuk Cody , Zello Gordon A. , Chilibeck Philip D.
Published: October 2021

COVID-19 transmission is prevalent during ice-hockey; however, it is unknown whether wearing face masks as a mitigation strategy affects hockey players’ performance. We used a randomized cross-over study to compare wearing a surgical mask to a sham mask (control) in youth hockey players (21 males, 5 females, 11.7 ± 1.6 y) during a simulated hockey period (cycle ergometry; six shifts of 20 s of “easy” pedaling (40% peak power), 10 s of “hard” pedaling (95% peak power), 20 s of “easy” pedaling, with shifts separated by 5 min rests). A seventh shift involved two 20 s Wingate tests separated by 40 s rest. Heart rate, arterial oxygen saturation and vastus lateralis tissue oxygenation index (hemoglobin saturation/desaturation) was assessed each shift. On-ice testing was conducted with the maximal Yo-Yo intermittent recovery test. No differences between mask and control conditions for performance were found (Wingate average power: 245 ± 93 vs. 237 ± 93 W, Peak power: 314 ± 116 vs. 304 ± 115 W, on-ice distance: 274 ± 116 vs. 274 ± 110 m) and for heart rate or arterial oxygen saturation during simulated hockey shifts. Tissue oxygenation index was lower from shifts one to six for males (p < 0.05) and shift seven for females (p < 0.01) while wearing a mask. Wearing a face mask had no effect on performance in hockey players with only minor effects on muscle oxygenation. ClinicalTrials.gov (NCT04874766) (accessed on 6 May 2021).
Point-of-Care COVID-19 Antigen Testing in Exposed German Healthcare Workers—A Cost Model
Authors: Diel Roland , Hittel Norbert , Nienhaus Albert
Published: October 2021

Background: Hospital staffing shortages are again (mid-year 2021) becoming a significant problem as the number of positive COVID-19 cases continues to increase worldwide. Objective: To assess the costs of sending HCW into quarantine (Scenario 1) from the hospital’s and the taxpayer’s perspective versus the costs arising from implementing point-of-care COVID-19 antigen testing (POCT) for those staff members who, despite learning that they have been exposed to hospital patients later found to be infected with COVID-19, continue to report to work (Scenario 2). Methods: A mathematical model was built to calculate the costs of a sample-and-stay strategy for exposed healthcare workers (HCW) in Germany by utilizing a high-quality antigen fluorescent immunoassay (FIA), compared to the costs of quarantine. Direct costs and wage costs were evaluated from the hospital as well as from the taxpayer perspective assuming a SARS-CoV-2 infection prevalence of 10%. Results: Serial POCT testing of exposed HCW in Germany (Scenario 2) who do not go into quarantine but continue to work during a post-exposure period of 14 days at their working place raises costs of EUR 289 (±20%: EUR 231 to EUR 346, rounded) per HCW at the expense of the employing hospital while the extra-costs to the taxpayer per exposed HCW are limited to EUR 16 (±20%: EUR 13 to EUR 19). In contrast, sending HCW into quarantine (Scenario 1) would result in costs of EUR 111 (±20%: EUR 89 to EUR 133) per exposed HCW for the hospital but EUR 2235 (±20%: EUR 1744 to EUR 2727) per HCW at the expense of the taxpayer. Conclusions: Monitoring exposed HCW who continued working by sequential POCT may considerably reduce costs from the perspective of the taxpayer and help mitigate personnel shortages in hospitals during pandemic COVID-19 waves.
Predicting Physical Exercise Adherence in Fitness Apps Using a Deep Learning Approach
Authors: Jossa-Bastidas Oscar , Zahia Sofia , Fuente-Vidal Andrea , Sánchez Férez Néstor , Roda Noguera Oriol , Montane Joel , Garcia-Zapirain Begonya
Published: October 2021

The use of mobile fitness apps has been on the rise for the last decade and especially during the worldwide SARS-CoV-2 pandemic, which led to the closure of gyms and to reduced outdoor mobility. Fitness apps constitute a promising means for promoting more active lifestyles, although their attrition rates are remarkable and adherence to their training plans remains a challenge for developers. The aim of this project was to design an automatic classification of users into adherent and non-adherent, based on their training behavior in the first three months of app usage, for which purpose we proposed an ensemble of regression models to predict their behaviour (adherence) in the fourth month. The study was conducted using data from a total of 246 Mammoth Hunters Fitness app users. Firstly, pre-processing and clustering steps were taken in order to prepare the data and to categorize users into similar groups, taking into account the first 90 days of workout sessions. Then, an ensemble approach for regression models was used to predict user training behaviour during the fourth month, which were trained with users belonging to the same cluster. This was used to reach a conclusion regarding their adherence status, via an approach that combined affinity propagation (AP) clustering algorithm, followed by the long short-term memory (LSTM), rendering the best results (87% accuracy and 85% F1_score). This study illustrates the suggested the capacity of the system to anticipate future adherence or non-adherence, potentially opening the door to fitness app creators to pursue advanced measures aimed at reducing app attrition.
Intelligent Coaching Assistant for the Promotion of Healthy Habits in a Multidomain mHealth-Based Intervention for Brain Health
Authors: Moreno-Blanco Diego , Solana-Sánchez Javier , Sánchez-González Patricia , Jiménez-Hernando Manuel , Cattaneo Gabriele , Roca Alba , Gomes-Osman Joyce , Tormos-Muñoz Josep María , Bartrés-Faz David , Pascual-Leone Álvaro , Gómez Enrique J.
Published: October 2021

Brain Health is defined as the development and preservation of optimal brain integrity and neural network functioning for a given age. Recent studies have related healthy habits with better maintenance of brain health across the lifespan. As a part of the Barcelona Brain Health Initiative (BBHI), a mHealth platform has been developed with the purpose of helping people to improve and monitor their healthy habits, facilitating the delivery of health coaching strategies. A decision support system (DSS), named Intelligent Coaching Assistant (ICA), has been developed to ease the work of professional brain health coaches, helping them design and monitor adherence to multidomain interventions in a more efficient manner. Personalized recommendations are based on users’ current healthy habits, individual preferences, and motivational aspects. Taking these inputs, an initial user profile is defined, and the ICA applies an algorithm for determining the most suitable personalized intervention plan. An initial validation has been done focusing on assessing the feasibility and usability of the solution, involving 20 participants for three weeks. We conclude that this kind of technology-based intervention is feasible and implementable in real-world settings. Importantly, the personalized intervention proposal generated by the DSS is feasible and its acceptability and usability are high.
Enhancing Interprofessional Collaboration in Perioperative Setting from the Qualitative Perspectives of Physicians and Nurses
Authors: Sillero Sillero Amalia , Buil Neus
Published: October 2021

Communication failures were a leading cause of sentinel events in the operation room due to frequently the communication breakdown occurs between physicians and nurses. This study explored the perspectives of surgical teams (nurses, physicians, and anaesthesiologists) on interprofessional collaboration and improvement strategies. A surgical team comprising eight perioperative nurses, four surgeons, and four anaesthesiologists from a university-affiliated hospital participated in this qualitative and phenomenological research from December 2018 to April 2019. Data were collected in in-depth interviews and were used in a thematic analysis according to Colaizzi to extract themes and categorised codes with the ATLAS.ti software. The result is presented in three generic categories: Barrier-like disruptive behaviours and lack of coordination of care; consequences by safety threats to the patient; overcoming barriers by shared decision making among professionals, flattened hierarchies, and teamwork/communication training. The conclusion is that different teams’ perspectives can facilitate genuine reflection, discussion, and implementation of targeted interventions to improve operating room interprofessional collaboration and overcome barriers and their consequences. Currently, there is a need to change towards interprofessional collaboration for optimal patient outcomes and to ensure all professionals’ expectations are met.
Association between Weight Loss and Food Form in Older Individuals Residing in Long-Term Care Facilities: 1-Year Multicenter Longitudinal Study
Authors: Endo Akemi , Watanabe Yutaka , Matsushita Takae , Okada Kazutaka , Ohara Yuki , Iwasaki Masanori , Ito Kayoko , Nakajima Junko , Iwasa Yasuyuki , Itoda Masataka , Sasaki Rikimaru , Nishi Yasuhiro , Furuya Junichi , Watanabe Yoshihiko , Umemoto George , Kishima Masako , Hirano Hirohiko , Sato Yuji , Yoshida Mitsuyoshi , Yamazaki Yutaka
Published: October 2021

Changing the food form for older adults requiring nursing care from a regular to dysphagia diet is thought to impact their nutritional status. We assessed the association between changes in food form and weight loss over 1 year in older adults. Older adults residing in long-term care facilities in Japan (n = 455) who participated in the baseline (2018) and follow-up (2019) surveys were divided into two groups (regular diet, n = 284; dysphagia diet, n = 171). The regular diet group was further divided into the weight loss (n = 80; weight loss ≥5% over 1 year) and weight maintenance (n = 204; weight loss <5%) groups. After 1 year, the Barthel Index significantly decreased, and the proportion of participants who switched from a regular diet to a dysphagia diet significantly increased in the weight loss group than in the weight maintenance group. Multivariate logistic regression analysis found that Barthel index variation (odds ratio (OR): 0.97, 95% confidence interval (CI): 0.94‒0.99), change from a regular diet to a dysphagia diet (OR: 4.41, 95% CI: 1.87‒10.41), and body weight at baseline (OR = 1.06, 95% CI: 1.01‒1.11) were significantly associated with weight loss. Our results suggest that maintaining the food form inhibits weight loss and improves health outcomes in older adults.
Protocol for the Implementation and Evaluation of a Mindfulness-Based Intervention for Caregivers of Children with Mental Disorders in a Clinical Setting
Authors: Pizarro-Carmona Ana , Baena Sofía , Jiménez Patricia , Jiménez Lucía
Published: October 2021

Being a parent is complicated in typical circumstances, with a great psychological impact as well as feelings and experiences of great intensity. This impact is greater in families in vulnerable situations, such as those with children with mental health problems, receiving treatment in a clinical setting. Due to these challenges, parenting in these circumstances is often accompanied by experiences of stress. An approach that has shown evidence of effectiveness in mitigating the negative impact of stress is mindfulness-based interventions, including the Mindfulness-Based Stress Reduction intervention program. The Mindfulness-Based Stress Reduction intervention program is designed as a psychoeducational, instructional, multimodal, and structured program whose main objective is to provide strategies for the management, coping, and awareness of stress in order to reduce it. In this paper, a protocol for the implementation and evaluation of the original Mindfulness-Based Stress Reduction intervention program with the added positive parenting component is presented, in order to systematize the incorporation of a parenting component in the Mindfulness-Based Stress Reduction intervention program, analyze its effectiveness for parents whose children have mental health problems (in terms of stress, mindfulness, emotional intelligence, general health, and parental role), explore the mechanisms of change operating in this intervention as perceived by the participants, and examine the application of acquired strategies to daily life.
Quest for Optimal Regression Models in SARS-CoV-2 Wastewater Based Epidemiology
Authors: Aberi Parisa , Arabzadeh Rezgar , Insam Heribert , Markt Rudolf , Mayr Markus , Kreuzinger Norbert , Rauch Wolfgang
Published: October 2021

Wastewater-based epidemiology is a recognised source of information for pandemic management. In this study, we investigated the correlation between a SARS-CoV-2 signal derived from wastewater sampling and COVID-19 incidence values monitored by means of individual testing programs. The dataset used in the study is composed of timelines (duration approx. five months) of both signals at four wastewater treatment plants across Austria, two of which drain large communities and the other two drain smaller communities. Eight regression models were investigated to predict the viral incidence under varying data inputs and pre-processing methods. It was found that population-based normalisation and smoothing as a pre-processing of the viral load data significantly influence the fitness of the regression models. Moreover, the time latency lag between the wastewater data and the incidence derived from the testing program was found to vary between 2 and 7 days depending on the time period and site. It was found to be necessary to take such a time lag into account by means of multivariate modelling to boost the performance of the regression. Comparing the models, no outstanding one could be identified as all investigated models are revealing a sufficient correlation for the task. The pre-processing of data and a multivariate model formulation is more important than the model structure.
Prevalence and Risk Factors of Psychiatric Symptoms among Swiss Elite Athletes during the First Lockdown of the COVID-19 Pandemic
Authors: Fröhlich Stefan , Imboden Christian , Iff Samuel , Spörri Jörg , Quednow Boris B. , Scherr Johannes , Seifritz Erich , Claussen Malte C.
Published: October 2021

The COVID-19 pandemic and the associated first lockdown measures may have had a relevant impact on the mental health of competitive athletes. This study aimed to evaluate the prevalence of various mental health issues in a Swiss elite athletes’ cohort during the first lockdown of the pandemic, and to assess their association with different potential risk factors. Elite athletes from different disciplines were interviewed during the first lockdown in spring 2020 by means of an online questionnaire on symptoms of existing anxieties, depression and sleep disorders, as well as on training circumstances and physical performance before and during the lockdown. Additionally, the economic situation, secondary occupations and current physical health problems were surveyed. A total of 203 (92 female, 111 male) athletes met the inclusion criteria and participated in the survey. Training volume and intensity decreased significantly during lockdown from 3.1 to 2.7 h/day. Financial existential fears increased and were associated with higher training volumes and higher trait anxiety scores. Depressive symptoms and insomnia were present but not exceptionally frequent during the lockdown. Depressive symptoms were associated with higher anxiety scores, higher insomnia severity scores, lower training intensity and worse coping with the measures taken by the authorities against the pandemic. Changes in training and daily habits due to the first lockdown may have affected the mental health of elite athletes. Longitudinal studies should, however, further investigate the long-term effects of the pandemic on mental health.
Analysis of the Correlation between Occupational Accidents and Economic Factors in China
Authors: Li Chengwu , Wang Xiangbing , Wei Chengmin , Hao Min , Qiao Zhen , He Yonghang
Published: October 2021

One of the important factors affecting the production safety of a country or region is the level of economic development. Avoiding accidents under the condition of ensuring economic development is a problem that needs in-depth research. On the basis of collecting the data of occupational accidents and economic development indicators in China from 2000 to 2020, this paper studies the relationship between occupational accidents and five economic indicators, such as resident consumption, energy consumption, education funds, wage level and research input. The grey working accident model of Gaussian function is established, the occurrence trend of occupational accidents is quantitatively analyzed, and the accident reduction measures are suggested based on the relationship between accidents and economy. The results show that there is a strong correlation between accident and economic indicators, and the comprehensive correlation coefficient among scientific research investment, education funds and accident indicators is significantly higher than that of other economic indicators. Increasing investment in scientific research and education is conducive to improving the quality of workers and training safety professionals and can effectively reduce workplace accidents.
A Spatial Analysis of COVID-19 in African Countries: Evaluating the Effects of Socio-Economic Vulnerabilities and Neighbouring
Authors: Manda Samuel O. M. , Darikwa Timotheus , Nkwenika Tshifhiwa , Bergquist Robert
Published: October 2021

The ongoing highly contagious coronavirus disease 2019 (COVID-19) pandemic, which started in Wuhan, China, in December 2019, has now become a global public health problem. Using publicly available data from the COVID-19 data repository of Our World in Data, we aimed to investigate the influences of spatial socio-economic vulnerabilities and neighbourliness on the COVID-19 burden in African countries. We analyzed the first wave (January–September 2020) and second wave (October 2020 to May 2021) of the COVID-19 pandemic using spatial statistics regression models. As of 31 May 2021, there was a total of 4,748,948 confirmed COVID-19 cases, with an average, median, and range per country of 101,041, 26,963, and 2191 to 1,665,617, respectively. We found that COVID-19 prevalence in an Africa country was highly dependent on those of neighbouring Africa countries as well as its economic wealth, transparency, and proportion of the population aged 65 or older (p-value < 0.05). Our finding regarding the high COVID-19 burden in countries with better transparency and higher economic wealth is surprising and counterintuitive. We believe this is a reflection on the differences in COVID-19 testing capacity, which is mostly higher in more developed countries, or data modification by less transparent governments. Country-wide integrated COVID suppression strategies such as limiting human mobility from more urbanized to less urbanized countries, as well as an understanding of a county’s social-economic characteristics, could prepare a country to promptly and effectively respond to future outbreaks of highly contagious viral infections such as COVID-19.
Processed and Unprocessed Red Meat Consumption and Risk for Type 2 Diabetes Mellitus: An Updated Meta-Analysis of Cohort Studies
Authors: Zhang Rui , Fu Jialin , Moore Justin B. , Stoner Lee , Li Rui
Published: October 2021

Type II diabetes mellitus (T2DM) is a metabolic disorder that occurs in the body because of decreased insulin activity and/or insulin secretion. The incidence of T2DM has rapidly increased over recent decades. The relation between consumption of different types of red meats and risk of T2DM remains uncertain. This meta-analysis was conducted to quantitatively assess the associations of processed red meat (PRM) and unprocessed red meat (URM) consumption with T2DM. We searched PubMed, Embase, Web of Science and The Cochrane Library for English-language cohort studies published before January 2021. Summary relative risks (RR) with 95% confidence interval (CI) were estimated using fixed effects and random effects. Additionally, dose–response relationships were explored using meta-regression. Fifteen studies (n = 682,963 participants, cases = 50,675) were identified. Compared with the lowest intake group, high consumption of PRM and URM increased T2DM risk by 27% (95% CI 1.15–1.40) and 15% (95% CI 1.08–1.23), respectively. These relationships were consistently strongest for U.S-based studies, though the effects of sex are inconclusive. In conclusion, PRM and URM are both positively associated with T2DM incidence, and these relationships are strongest in the U.S. reduction of red meat consumption should be explored as a target for T2DM prevention initiatives.
Women’s Health in/and Work: Menopause as an Intersectional Experience
Authors: Riach Kathleen , Jack Gavin
Published: October 2021

This paper employs an intersectional lens to explore menopausal experiences of women working in the higher education and healthcare sectors in Australia. Open-text responses from surveys across three universities and three healthcare settings were subject to a multistage qualitative data analysis. The findings explore three aspects of menopause experience that required women to contend with a constellation of aged, gendered and ableist dynamics and normative parameters of labor market participation. Reflecting on the findings, the paper articulates the challenges of menopause as issues of workplace inequality that are rendered visible through an intersectional lens. The paper holds a range of implications for how to best support women going through menopause at work. It emphasizes the need for approaches to tackle embedded and more complex modes of inequality that impact working women’s menopause, and ensure that workforce policy both protects and supports menopausal women experiencing intersectional disadvantage.
Epigenetic Regulation and Post-Translational Modifications of SNAI1 in Cancer Metastasis
Authors: Dong Bo , Wu Yadi
Published: October 2021

SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, and metabolic regulation. The regulation of SNAI1 occurs at the transcriptional, translational, and predominant post-translational levels including phosphorylation, acetylation, and ubiquitination. Here, we discuss the regulation and role of SNAI1 in cancer metastasis, with a particular emphasis on epigenetic regulation and post-translational modifications. Understanding how signaling networks integrate with SNAI1 in cancer progression will shed new light on the mechanism of tumor metastasis and help develop novel therapeutic strategies against cancer metastasis.
Long-Term Course of Hypothyroidism Detected through Neonatal TSH Screening in a Population-Based Cohort of Very Preterm Infants Born at Less than 32 Weeks of Gestation
Authors: Odenwald Birgit , Fischer Aline , Röschinger Wulf , Liebl Bernhard , Schmidt Heinrich , Nennstiel Uta
Published: October 2021

After several decades of successful newborn screening (NBS) for congenital hypothyroidism, the optimal hypothyroidism NBS algorithm for very preterm infants is still controversial. Due to concerns about an elevated risk of a false-negative initial thyroid-stimulation hormone (TSH) screening, repeat NBS has been implemented for this group. While transient hypothyroidism is known to be more frequent among very preterm infants, the prevalence of permanent hypothyroidism is generally assumed to be the same as in more mature newborns. This study analyses screening and long-term follow-up data from the population-based cohort of 51 infants born from 1999–2017 at less than 32 weeks of gestation and diagnosed with hypothyroidism after NBS in the German Federal State of Bavaria (total number of infants screened 2,107,864). Severe permanent hypothyroidism was always detected at initial TSH screening unless there was a known confounding factor. Cases detected by repeat screening after a negative initial screen most frequently proved to be transient, less frequently mild permanent, or a definitive diagnosis was not possible because of inadequate re-evaluation of the thyroid axis. The prevalence of both permanent and transient hypothyroidism was elevated compared to a cohort of children from the same region born at a higher gestational age. The results seem to support the need for the repeated NBS of very preterm infants. However, as the recommendation to treat mild hypothyroidism is not based on high quality evidence, important issues for future research include treatment outcome studies or even a general review of whether this diagnosis meets the screening criteria. Meanwhile, involving a paediatric endocrinologist in treatment decisions is crucial for optimising the benefit of hypothyroidism screening for this particularly vulnerable group.
Knockdown of Vacuolar ATPase Subunit G Gene Affects Larval Survival and Impaired Pupation and Adult Emergence in Henosepilachna vigintioctopunctata
Authors: Zeng Jie , Kang Wei-Nan , Jin Lin , Anjum Ahmad Ali , Li Guo-Qing
Published: October 2021

The vATPase holoenzyme consists of two functional subcomplexes, the cytoplasmic (peripheral) V1 and the membrane-embedded V0. Both V1 and V0 sectors contain eight subunits, with stoichiometry of A3B3CDE3FG3H in V1 and ac8c’c”def(Voa1p) in V0 respectively. However, the function of G subunit has not been characterized in any non-Drosophilid insect species. In the present paper, we uncovered that HvvATPaseG was actively transcribed from embryo to adult in a Coleopteran pest Henosepilachna vigintioctopunctata. Its mRNA levels peaked in larval hindgut and Malpighian tubules. RNA interference (RNAi)-mediated knockdown of HvvATPaseG significantly reduced larval feeding, affected chitin biosynthesis, destroyed midgut integrity, damaged midgut peritrophic membrane, and retarded larval growth. The function of Malpighian tubules was damaged, the contents of glucose, trehalose, lipid, total soluble amino acids and protein were lowered and the fat bodies were lessened in the HvvATPaseG RNAi larvae, compared with those in the PBS- and dsegfp-fed beetles. In contrast, the amount of glycogen was dramatically increased in the HvvATPaseG depletion ladybirds. As a result, the development was arrested, pupation was inhibited and adult emergence was impaired in the HvvATPaseG hypomorphs. Our results demonstrated that G subunit plays a critical role during larval development in H. vigintioctopunctata.
The Conceptualisation and Development of a Space-Saving Multipurpose Table for Enhanced Ergonomic Performance
Authors: Cheng Hou Yip , Ng Poh Kiat , Nathan Robert Jeyakumar , Saptari Adi , Ng Yu Jin , Yeow Jian Ai , Ng Kim Yun
Published: October 2021

Foldable furniture is a trend of the modern furniture industry. However, apart from limitations attributed to multifunctionality and space saving characteristics, a complete design process documentation of foldable furniture is uncommon in furniture research. This study aims to develop a space-saving multipurpose table for improved ergonomic performance. Features and functions are extracted from research articles and patents for concept generation. The final concept is modelled using Autodesk Inventor Professional 2019. Mechanical simulations are done to confirm the structural integrity of the invention before prototyping and testing. The tests accounted for usage efficiency, space and usability. Using Minitab 19, the experimental data are analysed with t-tests. The survey data are analysed using Spearman’s correlation test via IBM SPSS Statistics version 21. Participants were able to complete tasks around 1.1–1.5 times faster with the proposed invention than with single-function furniture items. The amount of space occupied with the proposed invention was approximately 25–80% lesser than with the single-function furniture items placed together. The survey analysis demonstrated that there was a strong, positive and significant correlation between space saving effectiveness and ergonomic performance. Further developments to transition this invention to its commercialisation phase should be done to facilitate daily living domestic activities of society at large.
Random Forest Modeling for Fly Ash-Calcined Clay Geopolymer Composite Strength Detection
Authors: Gupta Priyanka , Gupta Nakul , Saxena Kuldeep K. , Goyal Sudhir
Published: October 2021

Geopolymer is an eco-friendly material used in civil engineering works. For geopolymer concrete (GPC) preparation, waste fly ash (FA) and calcined clay (CC) together were used with percentage variation from 5, 10, and 15. In the mix design for geopolymers, there is no systematic methodology developed. In this study, the random forest regression method was used to forecast compressive strength and split tensile strength. The input content involved were caustic soda with 12 M, 14 M, and 16 M; sodium silicate; coarse aggregate passing 20 mm and 10 mm sieve; crushed stone dust; superplasticizer; curing temperature; curing time; added water; and retention time. The standard age of 28 days was used, and a total of 35 samples with a target-specified compressive strength of 30 MPa were prepared. In all, 20% of total data were trained, and 80% of data testing was performed. Efficacy in terms of mean absolute error (MAE), root mean square error (RMSE), coefficient of determination (R2), and MSE (mean squared error) is suggested in the model. The results demonstrated that the RFR model is likely to predict GPC compressive strength (MAE = 1.85 MPa, MSE = 0.05 MPa, RMSE = 2.61 MPa, and R2 = 0.93) and split tensile strength (MAE = 0.20 MPa, MSE = 6.83 MPa, RMSE = 0.24 MPa, and R2 = 0.90) during training.
Prediction of the Propeller Performance at Different Reynolds Number Regimes with RANS
Authors: Baltazar João , Rijpkema Douwe , Falcão de Campos José
Published: October 2021

In this study, a Reynolds averaged Navier-Stokes solver is used for prediction of the propeller performance in open-water conditions at different Reynolds numbers ranging from 104 to 107. The k−ω SST turbulence model and the γ−R˜eθt correlation-based transition model are utilised and results compared for a conventional marine propeller. First, the selection of the turbulence inlet quantities for different flow regimes is discussed. Then, an analysis of the iterative and discretisation errors is made. This work is followed by an investigation of the predicted propeller flow at variable Reynolds numbers. Finally, the propeller scale-effects and the influence of the turbulence and transition models on the performance prediction are discussed. The variation of the flow regime showed an increase in thrust and decrease in torque for increasing Reynolds number. From the comparison between the turbulence model and the transition model, different flow solutions are obtained for the Reynolds numbers between 105 and 106, affecting the scale-effects prediction.