bluuebunny/crossref_metadata_2025 huggingface dataset:
Age-Stage, Two-Sex Life Table and Functional Response of Amblyseius orientalis (Acari: Phytoseiidae) Feeding on Different Nutrient Sources
Authors: Pan Keyu , Xin Tianrong , Chen Yibing , Wang Hongyan , Wen Kexin , Liu Yimeng , Li Zhenzhen , Zou Zhiwen , Xia Bin
Published: October 2022

Amblyseius orientalis Ehara is a predatory mite that belongs to the family Phytoseiidae. It is mainly found in Jiangxi, Shanghai, Guangdong, and other areas of China. Although A. orientalis is a dominant predatory mite species in China and is also important for agriculture and biological control, not many studies have investigated it. Thus, research on A. orientalis is necessary. However, its application in biological control is hindered by the absence of techniques for the mass rearing of A. orientalis in captivity. We conducted experiments to determine the growth, development, reproduction, and functional response of A. orientalis in this study by indoor single-head rearing at 25 ± 1 °C, 65 ± 5% relative humidity, and a photoperiod of a 16 h:8 h light/dark cycle under laboratory conditions. The results of the age stage, two-sex life table showed that the individuals in the pollen + yeast and pollen + yeast + sucrose groups had significantly higher oviposition period, fecundity, net reproductive rate (R0), and gross reproduction rate (GRR) than those in the pollen group. The results of the function response showed that the pollen + yeast + sucrose group was the most favorable for captive breeding of A. orientalis and had the best predatory ability along with rejuvenation and recovery ability. The results of the study provided a theoretical basis for indoor rearing, propagation, and utilization of A. orientalis.
The Mechanism and Role of N6-Methyladenosine (m6A) Modification in Atherosclerosis and Atherosclerotic Diseases
Authors: Tan Quandan , He Song , Leng Xinyi , Zheng Danni , Mao Fengkai , Hao Junli , Chen Kejie , Jiang Haisong , Lin Yapeng , Yang Jie
Published: October 2022

N6-methyladenosine (m6A) modification is a newly discovered regulatory mechanism in eukaryotes. As one of the most common epigenetic mechanisms, m6A’s role in the development of atherosclerosis (AS) and atherosclerotic diseases (AD) has also received increasing attention. Herein, we elucidate the effect of m6A on major risk factors for AS, including lipid metabolism disorders, hypertension, and hyperglycemia. We also describe how m6A methylation contributes to endothelial cell injury, macrophage response, inflammation, and smooth muscle cell response in AS and AD. Subsequently, we illustrate the m6A-mediated aberrant biological role in the pathogenesis of AS and AD, and analyze the levels of m6A methylation in peripheral blood or local tissues of AS and AD, which helps to further discuss the diagnostic and therapeutic potential of m6A regulation for AS and AD. In summary, studies on m6A methylation provide new insights into the pathophysiologic mechanisms of AS and AD, and m6A methylation could be a novel diagnostic biomarker and therapeutic target for AS and AD.
Raman Analyses of Laser Irradiation-Induced Microstructural Variations in Synthetic Hydroxyapatite and Human Teeth
Authors: Imamura Hayata , Zhu Wenliang , Adachi Tetsuya , Hiraishi Noriko , Marin Elia , Miyamoto Nao , Yamamoto Toshiro , Kanamura Narisato , Pezzotti Giuseppe
Published: October 2022

The microstructural and molecular-scale variations induced by laser irradiation treatment on human teeth enamel in comparison with synthetic hydroxyapatite (HAp) were examined through Raman microprobe spectroscopy as a function of irradiation power. The results demonstrated that laser irradiation could modify stoichiometry, microstructure, and the population of crystallographic defects, as well as the hardness of the materials. These modifications showed strong dependences on both laser power and initial nonstoichiometric structure (defective content of HPO4), because of the occurrence of distinct reactions and structural reconstruction. The reported observations can redirect future trends in tooth whitening by laser treatment and the production of HAp coatings because of the important role of stoichiometric defects.
Surface Free Energy and Composition Changes and Ob Cellular Response to CHX-, PVPI-, and ClO2-Treated Titanium Implant Materials
Authors: Masa Roland , Pelsőczi-Kovács István , Aigner Zoltán , Oszkó Albert , Turzó Kinga , Ungvári Krisztina
Published: October 2022

The study evaluated the interaction of a titanium dental implant surface with three different antibacterial solutions: chlorhexidine, povidone-iodine, and chlorine dioxide. Implant surface decontamination is greatly challenging modern implant dentistry. Alongside mechanical cleaning, different antibacterial agents are widely used, though these could alter implant surface properties. Commercially pure (CP) grade 4 titanium (Ti) discs were treated with three different chemical agents (chlorhexidine 0.2% (CHX), povidone-iodine 10% (PVPI), chlorine dioxide 0.12% (ClO2)) for 5 min. Contact angle measurements, X-ray photoelectron spectroscopy (XPS) analysis, and cell culture studies were performed. Attachment and proliferation of primary human osteoblast cells were investigated via MTT (dimethylthiazol–diphenyl tetrazolium bromide), alamarBlue, LDH (lactate dehydrogenase), and fluorescent assays. Contact angle measurements showed that PVPI-treated samples (Θ = 24.9 ± 4.1) gave no difference compared with controls (Θ = 24.6 ± 5.4), while CHX (Θ = 47.2 ± 4.1) and ClO2 (Θ = 39.2 ± 9.8) treatments presented significantly higher Θ values. All samples remained in the hydrophilic region. XPS analysis revealed typical surface elements of CP grade 4 titanium (Ti, O, and C). Both MTT and alamarBlue cell viability assays showed similarity between treated and untreated control groups. The LDH test revealed no significant difference, and fluorescent staining confirmed these results. Although there was a difference in surface wettability, a high proliferation rate was observed in all treated groups. The in vitro study proved that CHX, PVPI, and ClO2 are proper candidates as dental implant decontamination agents.
Efficiency Analysis of the Coastal Port Group in the Yangtze River Delta
Authors: Yu Siqin , Gong Lina , Qi Mingyun
Published: October 2022

In recent years, the coastal ports of the Yangtze River Delta have rapidly developed with the progress of science and technology, which has caused some problems on account of the rapid development of ports. On the one hand, there is fierce competition within the same port group; on the other hand, many ports waste resources. This study selected the three-stage data envelopment analysis (DEA) and Malmquist index models to calculate and analyze the efficiency value of the coastal port group in the Yangtze River Delta; the study was conducted to make a reference for the formulation of the optimization strategy from the perspectives of static and dynamic efficiency. The results show that from the perspective of static efficiency, the comprehensive efficiency of the Yangtze River Delta coastal port cluster is at the upper-middle level. However, it has not yet reached the frontier surface, and the low scale efficiency is why the port group has not been called the frontier surface. From the perspective of dynamic efficiency, the total factor productivity of the Yangtze River Delta port group has increased by 3.6% in the past five years. Technological progress and comprehensive technical efficiency have improved. The optimization strategy was formulated according to the problems faced by the Yangtze River Delta port group and the reasons for not reaching the frontier.
Spatio-Temporal Trend of Past and Future Extreme Wave Climates in the Gulf of Guinea Driven by Climate Change
Authors: Dahunsi Adeola M. , Bonou Frédéric , Dada Olusegun A. , Baloïtcha Ezinvi
Published: October 2022

This study assessed the extremes of wave conditions for past (1979–2005) and future (2026–2045 and 2081–2100) time slices in the Gulf of Guinea (GoG). The ensemble produced from eight General Circulation Models under different Representative Concentration Pathway (RCP) emission scenarios (RCP4.5 and RCP8.5) was subjected to linear regression analysis and Mann–Kendal test for their trends and significance, respectively. Results showed an increase in the extreme of significant wave height (Hs) and mean wave period (Tm) between 1979–2005, 2026–2045, and 2081–2100 with few exceptions. The average values of annual and seasonal Hs and Tm range from 1.26–1.62 m and 10.37 s–10.86 s, respectively, for 1979–2005. These Hs values are projected to increase by 0.1 m (0.05 m) to 1.72 m (1.67 m) and the Tm will increase by 0.29 s (0.24 s) to 11.15 s (11.10 s) by the end of the century (mid-century) time slices, respectively. The mean wave direction (Dm) (201.89°–206.27°) showed an anticlockwise shift (−29.2 × 10−3 degrees per year) for 1979–2005 which is projected to become more southwesterly with an increase up to 2.2° (0.5°) by end (mid) century in 2100 (2045), respectively. Future work will be on the impacts of changing wave on longshore sediment transport along the GoG.
Numerical Simulation on Dynamic Characteristics of Longitudinal Launching of Large Container Ships
Authors: Liu Kaihua , Wang Yu , Wu Zhifei , Pi Juntao , Gho Wie Min , Zhou Bo
Published: October 2022

The upsizing and rapid development of container ships has resulted in many large ships launching in small slipways due to the lagging of advanced equipment. In particular, the dynamic characteristics of these large ships in the longitudinal launching operation under restricted water are yet to be studied in detail. In this study, a ship model to simulate the longitudinal launching process of an 8500 TEU container ship was created based on the URANS method. The ship resistance in calm water was determined and validated against the experimental data. The influence of the stern appendage on the ship’s resistance and the flow field around the hull, with and without the aft poppet, under various water-depth-to-draught ratios was analyzed. A comparison of the ship’s resistance between the numerical and the experimental data shows that the difference is minimal, within 1.5%. The numerical results revealed that the aft poppets change the flow pattern and effectively reduce the pressure drag in the drifting stage. The shallow water causes a restraining effect on the ship. The proposed analytical approach in the numerical analysis, considering the aft poppet and the water depth, could provide a better simulation for a large ship’s longitudinal launching operation.
The Issue of Using Ordinal Quantities to Estimate the Vulnerability of Seabirds to Wind Farms
Authors: Shavykin Anatoly , Karnatov Andrey
Published: October 2022

The article is a follow-up study to research on analysing methodological approaches to estimate anthropogenic impacts on marine biota. The work examines relevant publications about the vulnerability of seabirds to the effects of offshore wind farms, relying upon the provisions of the measurement theory and the median theorem for ordinal quantities. It has been shown that the final ranking of sensitivity of certain bird species to wind farms, or indices of a risk of collisions with turbine blades and indices of a risk of birds’ displacement by wind farms, can vary at permissible monotonic transformations of the values of initial factors since all of these are estimated on ordinal scales. We conclude such estimates are incorrect. The summation of the two indices (exposure to collisions with turbine blades and to habitat change) of the birds’ species vulnerability in the context of the proposed models is incorrect. It has been demonstrated that the model based on dividing factors into primary and aggravation, when the latter are incorporated into the formula of computation through the exponent of primary factors, is incorrect: when primary factors have maximum values (equal to 1), the effect of aggravation factors is no longer taken into account; with some values of factors in the model, infinite vulnerability values can be obtained. The models are to operate within the entire presented range of initial data, but that is not fulfilled. Thus, none of the analysed models are correct, and an approach is needed, based on the use of metric values. Considering that the bird flight altitude primarily determines the impact of wind farms on birds, the proposals have been formulated to take into account the impact of various factors on the flight altitude.
Sterylglucosides in Fungi
Authors: Pereira de Sa Nivea , Del Poeta Maurizio
Published: October 2022

Sterylglucosides (SGs) are sterol conjugates widely distributed in nature. Although their universal presence in all living organisms suggests the importance of this kind of glycolipids, they are yet poorly understood. The glycosylation of sterols confers a more hydrophilic character, modifying biophysical properties of cell membranes and altering immunogenicity of the cells. In fungi, SGs regulate different cell pathways to help overcome oxygen and pH challenges, as well as help to accomplish cell recycling and other membrane functions. At the same time, the level of these lipids is highly controlled, especially in wild-type fungi. In addition, modulating SGs metabolism is becoming a novel tool for vaccine and antifungal development. In the present review, we bring together multiple observations to emphasize the underestimated importance of SGs for fungal cell functions.
Framework for Screening and Evaluating the Competencies and Qualities of the Board of Directors in South Africa’s State-Owned Companies
Authors: Hlobo Modi , Moloi Tankiso , Marx Benjamin
Published: October 2022

Purpose—This research paper presents a framework for screening and evaluating the competencies and qualities of the board of directors in South African state-owned companies (SOCs). Design/methodology/approach—This study conducted a systematic literature review to gather primary data which was used to prepare a questionnaire for two rounds of the Delphi process, where data was analysed both qualitatively and quantitatively. Findings—The findings from the study revealed the ideal competencies and qualities of individual directors, the optimal collective competencies of directors, and the most appropriate screening and evaluation methods that could be adopted to benefit SOCs. Originality/value—This paper adds to the limited studies investigating the competencies and qualities of directors in SOCs, as most research is focused on listed private companies. Furthermore, there is currently no framework in South Africa that outlines the process for screening and evaluating the competencies and qualities of directors in South Africa’s SOCs. In an effort to support the South African government screen and evaluate the key competencies and qualities of directors in state-owned companies, this team has developed a theoretically informed framework that can be used to screen potential board members’ abilities and capabilities before they are appointed as well as to evaluate the relevance of existing board members.
A Predictive Model of Early Readmission for Patients with Heart Failure
Authors: Hu Jian-Bo , He Zhong-Kai , Cheng Li , Zheng Chong-Zhou , Wu Bao-Zhen , He Yuan , Su Li
Published: October 2022

Background: Readmission within 30 days of discharge for heart failure (HF) has become a challenging public health issue. Predicting the risk of 30-day readmission may assist clinicians in making individualized treatment plans for HF patients. Methods: A total of 2254 patients were enrolled in this study. The risk predictors associated with 30-day readmission were selected using the least absolute shrinkage and the selection operator regression model. The performance of the nomogram was evaluated using the receiver operating characteristic (ROC) curve, Hosmer–Lemeshow (HL) test, and decision curve analysis (DCA). Results: The 30-day all-cause readmission rate was 7.1%. Thirteen clinical parameters were identified as the risk predictors, including age, cystatin C, albumin, red cell distribution width coefficient variation, neutrophils, N-terminal pro-B-type natriuretic peptide, high-sensitivity cardiac troponin T, myoglobin, sex, dyslipidaemia, left ventricular ejection fraction, left ventricular end-diastolic dimension, and atrial fibrillation. The nomogram showed good discrimination, with an area under the ROC curve of 0.653 (95% confidence interval: 0.608–0.698) and good calibration results (HL test p = 0.328). The DCA showed that the nomogram would have good clinical utility. Conclusions: This predictive model based on clinical data makes it simple for clinicians to assess the 30-day HF readmission risk.
Valuation of Land-Use/Land-Cover-Based Ecosystem Services in Afghanistan—An Assessment of the Past and Future
Authors: Najmuddin Omaid , Li Zhihui , Khan Rabnawaz , Zhuang Weiqing
Published: October 2022

Being one of the weakest economies in the world, livelihoods in Afghanistan remain highly dependent on local ecosystem services. However, the risk of ecosystem services degradation in Afghanistan over the past two decades has significantly increased, mainly due to rapid changes in land-use and land-cover (LULC). As such, policy makers must be able to estimate the impact of LULC changes on various ecosystem services. By utilizing GlobeLand30 land cover products for 2000, 2010 and 2020, and by adopting the value transfer method, this study assessed the ecosystem services value (ESV) changes in response to the changes of LULC in Afghanistan. Additionally, the dynamics of the land system (DLS) model was innovatively coupled with linear programming to predict likely scenarios of ESV changes by 2030. The predicted results were also validated against actual land cover and achieved a Kappa value of 0.78. The results showed that over the 20-year period, ecologically important LULC categories such as forest, water bodies and grassland were severely unstable and rapidly decreasing in scope. These LULC types were being threatened by agricultural, built-up and unused lands. During this period, we estimated a decrease in the total ESV from 161 billion USD in 2000 to 152.27 billion USD in 2020. About 92% of this decrease was shared by supporting and provisioning services. The simulated scenarios also showed that ESV will likely further decrease under Business-As-Usual (BAU), and Rapid Economic Development (RED) scenarios. Positively, an Environmental Protection (ENP) scenario is predicted, with a 4.5% increase in ESV by 2030. However, achieving this scenario requires the enforcement of strict environmental protection measures.
Traceback and Chunk-Based Learning: Comparing Usage-Based Computational Approaches to Child Code-Mixing
Authors: Koch Nikolas , Hartmann Stefan , Endesfelder Quick Antje
Published: October 2022

Recent years have seen increased interest in code-mixing from a usage-based perspective. In usage-based approaches to monolingual language acquisition, a number of methods have been developed that allow for detecting patterns from usage data. In this paper, we evaluate two of those methods with regard to their performance when applied to code-mixing data: the traceback method, as well as the chunk-based learner model. Both methods make it possible to automatically detect patterns in speech data. In doing so, however, they place different theoretical emphases: while traceback focuses on frame-and-slot patterns, chunk-based learner focuses on chunking processes. Both methods are applied to the code-mixing of a German–English bilingual child between the ages of 2;3 and 3;11. Advantages and disadvantages of both methods will be discussed, and the results will be interpreted against the background of usage-based approaches.
Modality in Arabic: The Multiple Functions of the (Non)-Indicative Markers -ūn and b-
Authors: Valenzuela Mochón Estefanía
Published: October 2022

This paper explores the non-indicative modal meanings that the classical indicative plural inflection -ūn and the preverbal particle b- express in different varieties of Arabic. Moreover, it argues that these two forms allow the speaker to introduce a marked stance in specific grammatical contexts, where the choice of -ūn or b- clearly introduces a modal reading to the proposition. Taking a comparative approach to examine modality in Arabic, I build on examples taken from Classical Arabic (CLA), premodern non-standard written (NSW) documents, and modern dialects to analyze the modal behavior of -ūn and b-. Analysis of the data reveals the following: (1) preverbal b- is used to create rhetorical contrast, and (2) either -ūn or b- can overtly signal authoritative expectations (and orders) and/or intention. These results suggest an interesting connection between the modal roles played by -ūn and b- across Arabic varieties and demonstrate the importance of NSW texts in tracing the historical development of modality in Arabic.
Corrosion Behavior and Mechanical Performance of 7085 Aluminum Alloy in a Humid and Hot Marine Atmosphere
Authors: Tao Jianquan , Xiang Lin , Zhang Yanping , Zhao Zude , Su Yan , Chen Qiang , Sun Jipeng , Huang Bo , Peng Feifei
Published: October 2022

This work analyzed changes in the corrosion morphology and mechanical performance of 7085 aluminum alloy after outdoor exposures for different times in a humid and hot marine atmospheric environment. After one month of exposure, a pronounced corrosion of the alloy was observed. The corrosion product was mainly Al(OH)3, and the corrosion features were mainly pitting corrosion and intergranular corrosion (IGC). With the exposure time extended from 6 months to 12 months, the IGC depth increased from 114 μm to 190 μm. After a 1-year outdoor exposure in a humid and hot marine environment, the alloy’s ultimate strength and yield stress remained nearly unchanged, while its elongation and area reduction decreased from the original 6% and 9%, respectively, to 3% and 5%. Moreover, the reasons for IGC and its effect on the mechanical performance was analyzed.
Path Planning for 5-Axis CMM Inspection Considering Path Reuse
Authors: Zhao Wenzheng , Wang Xueqi , Liu Yinhua
Published: October 2022

The 5-axis Coordinate Measuring Machine (CMM) is widely used for quality data collection of the machining parts, such as cylinder blocks and heads of the engines. High efficient inspection path planning for multiple feature groups from different stations is one of the key tasks for CMM application. In engineering practice, the inspection planning of diverse feature groups accounts for large labor cost and process development cycle. To improve the efficiency of path generation for the complex machining part, a five-axis CMM inspection path planning method considering path length, probe rotation and path reusability is proposed. Firstly, the measuring points (MPs) are classified based on feasible inspection direction cone and accessibility of the MPs to achieve the minimum times of probe rotation. Then, the rapidly exploring random trees with multi-root node (RRT-MRNC) algorithm is proposed to implement local path planning considering inspection path reuse. Furthermore, intra-group and inter-group path is generated simultaneously based on the proposed enhanced Genetic Algorithm (GA) algorithm. In order to evaluate the effectiveness of the proposed method, the cylinder block path planning case is used. Compared with the benchmark methods, the total planning time based on the proposed planning method for the dynamic tasks was reduced by 55.2% and 54.9% respectively.
Deep Reinforcement Learning for Model Predictive Controller Based on Disturbed Single Rigid Body Model of Biped Robots
Authors: Hou Landong , Li Bin , Liu Weilong , Xu Yiming , Yang Shuhui , Rong Xuewen
Published: October 2022

This paper modifies the single rigid body (SRB) model, and considers the swinging leg as the disturbances to the centroid acceleration and rotational acceleration of the SRB model. This paper proposes deep reinforcement learning (DRL)-based model predictive control (MPC) to resist the disturbances of the swinging leg. The DRL predicts the swing leg disturbances, and then MPC gives the optimal ground reaction forces according to the predicted disturbances. We use the proximal policy optimization (PPO) algorithm among the DRL methods since it is a very stable and widely applicable algorithm. It is an on-policy algorithm based on the actor–critic framework. The simulation results show that the improved SRB model and the PPO-based MPC method can accurately predict the disturbances of the swinging leg to the SRB model and resist the disturbance, making the locomotion more robust.
Research on the Influence of the Assembly Parameters of the Junction Surface of Ultrasonic Acoustic Components on the Acoustic Performance Parameters
Authors: Ye Hongxian , Huang Xiangkui , Hu Xiaoping , Yu Baohua
Published: October 2022

The core of the ultrasonic machining system is the acoustic vibration component. Due to the inconsistency of the assembly conditions between the junction surfaces of the acoustic vibration component, the resonant frequency of the ultrasonic acoustic vibration component after the size adjustment of the ultrasonic horn is low, and the Impedance mismatch occurs in the ultrasonic system. In this paper, considering the influence of assembly conditions, the optimal assembly parameters were studied to reduce the junction surface’s influence on the ultra-sonic horn’s performance parameters. The paper analyzed the assembly structure, assembly parameters, and static and dynamic performance parameters of the acoustic vibration components and established a static and dynamic performance parameter measurement system. The assembly parameters of the ultrasonic acoustic vibration components were analyzed and determined. The static performance parameters of the ultrasonic acoustic components were measured and analyzed for the assembly parameters of the junction surface at the ultrasonic horn and the straight-edged knife. The optimal assembly parameters were preliminarily determined based on the analysis of the static performance parameters. The optimal assembly parameters of the junction surface of the ultrasonic horn and the straight-edged knife were determined through the measurement and analysis of the dynamic performance parameters of the two junction surfaces. The work is the basis for the adjustment of the ultrasonic horn. It also provides a basis for improving the working performance, manufacturing precision, and production efficiency of the ultrasonic horn while further popularizing the application of ultrasonic processing.
Fungus-Based Magnetic Nanobiocomposites for Environmental Remediation
Authors: Chaves Thais de Oliveira , Bini Raquel Dosciatti , Oliveira Junior Verci Alves de , Polli Andressa Domingos , Garcia Adriana , Dias Gustavo Sanguino , Santos Ivair Aparecido dos , Nunes de Oliveira Paula , Pamphile João Alencar , Cotica Luiz Fernando
Published: October 2022

The use of a variety of microorganisms for the degradation of chemicals is a green solution to the problem of environmental pollution. In this work, fungi–magnetic nanoparticles were studied as systems with the potential to be applied in environmental remediation and pest control in agriculture. High food demand puts significant pressure on increasing the use of herbicides, insecticides, fungicides, pesticides, and fertilizers. The global problem of water pollution also demands new remediation solutions. As a sustainable alternative to commercial chemical products, nanobiocomposites were obtained from the interaction between the fungus M. anisopliae and two different types of magnetic nanoparticles. Fourier transform infrared spectroscopy, optical and electron microscopy, and energy dispersive spectroscopy were used to study the interaction between the fungus and nanoparticles, and the morphology of individual components and the final nanobiocomposites. Analyses show that the nanobiocomposites kept the same morphology as that of the fungus in natura. Magnetic measurements attest the magnetic properties of the nanobiocomposites. In summary, these nanobiocomposites possess both fungal and nanoparticle properties, i.e., nanobiocomposites were obtained with magnetic properties that provide a low-cost approach benefiting the environment (nanobiocomposites are retrievable) with more efficiency than that of the application of the fungus in natura.
Backstepping Control Strategy of an Autonomous Underwater Vehicle Based on Probability Gain
Authors: Peng Yudong , Guo Longchuan , Meng Qinghua
Published: October 2022

In this paper, an underwater robot system with nonlinear characteristics is studied by a backstepping method. Based on the state preservation problem of an Autonomous Underwater Vehicle (AUV), this paper applies the backstepping probabilistic gain controller to the nonlinear system of the AUV for the first time. Under the comprehensive influence of underwater resistance, turbulence, and driving force, the motion of the AUV has strong coupling, strong nonlinearity, and an unpredictable state. At this time, the system’s output feedback can solve the problem of an unmeasurable state. In order to achieve a good control effect and extend the cruising range of the AUV, first, this paper will select the state error to make it a new control objective. The system’s control is transformed into the selection of system parameters, which greatly simplifies the degree of calculation. Second, this paper introduces the concept of a stochastic backstepping control strategy, in which the robot’s actuators work discontinuously. The actuator works only when there is a random disturbance, and the control effect is not diminished. Finally, the backstepping probabilistic gain controller is designed according to the nonlinear system applied to the simulation model for verification, and the final result confirms the effect of the controller design.
Compactness in Groups of Group-Valued Mappings
Authors: Caponetti Diana , Trombetta Alessandro , Trombetta Giulio
Published: October 2022

We introduce the concepts of extended equimeasurability and extended uniform quasiboundedness in groups of group-valued mappings endowed with a topology that generalizes the topology of convergence in measure. Quantitative characteristics modeled on these concepts allow us to estimate the Hausdorff measure of noncompactness in such a contest. Our results extend and encompass some generalizations of Fréchet–Šmulian and Ascoli–Arzelà compactness criteria found in the literature.
Is Biportal Endoscopic Spine Surgery More Advantageous Than Uniportal for the Treatment of Lumbar Degenerative Disease? A Meta-Analysis
Authors: Xu Wen-Bin , Kotheeranurak Vit , Zhang Huang-Lin , Chen Zhang-Xin , Wu Hua-Jian , Chen Chien-Min , Lin Guang-Xun , Rui Gang
Published: October 2022

Background and Objectives: To estimate the clinical outcomes of uniportal and biportal full-endoscopic spine surgery for the treatment of lumbar degenerative disease (LDD), and to provide the latest evidence for clinical selection. Materials and Methods: Relevant literatures published in PubMed, Web of Science, Embase, CNKI, and WanFang Database before 21 November 2021 were searched systematically. Two researchers independently screened the studies, extracted data, and evaluated the risk of bias of the included studies. The systematic review and meta-analysis were performed using the Review Manager software (version 5.4; The Cochrane Collaboration). Results: A total of seven studies were included in this meta-analysis, including 198 patients in a uniportal endoscopy group and 185 patients in a biportal endoscopy group. The results of this meta-analysis demonstrated that the biportal endoscopy group experienced less intraoperative estimated blood loss (WMD = −2.54, 95%CI [−4.48, −0.60], p = 0.01), while the uniportal endoscopy group displayed significantly better recovery results in Visual Analog Scale (VAS) assessments of the back within 3 days of surgery (WMD = 0.69, 95%CI [0.02, 1.37], p = 0.04). However, no significant differences in operation time, length of hospital stay, complication rates, Oswestry Disability Index (ODI) (within 3 months), ODI (last follow-up), VAS for back (within 3 months), VAS for back (last follow-up), and VAS for leg (within 3 days, within 3 months, last follow-up) were identified between the two groups. Conclusions: According to our meta-analysis, patients who underwent the uniportal endoscopic procedure had more significant early postoperative back pain relief than those who underwent the biportal endoscopic procedure. Nevertheless, both surgical techniques are safe and effective.
Massive Spontaneous Pneumomediastinum—A Form of Presentation for Severe COVID-19 Pneumonia
Authors: Pescaru Camelia Corina , Marc Monica Steluța , Costin Emanuela Oana , Pescaru Andrei , Trusculescu Ana-Adriana , Maritescu Adelina , Suppini Noemi , Oancea Cristian Iulian
Published: October 2022

For COVID-19 pneumonia, many manifestations such as fever, dyspnea, dry cough, anosmia and tiredness have been described, but differences have been observed from person to person according to age, pulmonary function, damage and severity. In clinical practice, it has been found that patients with severe forms of infection with COVID-19 develop serious complications, including pneumomediastinum. Although two years have passed since the beginning of the pandemic with the SARS-CoV-2 virus and progress has been made in understanding the pathophysiological mechanisms underlying the COVID-19 infection, there are also unknown factors that contribute to the evolution of the disease and can lead to the emergence some complications. In this case report, we present a patient with COVID-19 infection who developed a massive spontaneous pneumomediastinum and subcutaneous emphysema during hospitalization, with no pre-existing lung pathology and no history of smoking. The patient did not get mechanical ventilation or chest trauma, but the possible cause could be severe alveolar inflammation. The CT results highlighted pneumonia in context with SARS-CoV-2 infection affecting about 50% of the pulmonary area. During hospitalization, lung lesions evolved 80% pulmonary damage associated with pneumomediastinum and subcutaneous emphysema. After three months, the patient completely recovered and the pneumomediastinum fully recovered with the complete disappearance of the lesions. Pneumomediastinum is a severe and rare complication in COVID-19 pneumonia, especially in male patients, without risk factors, and an early diagnosis can increase the chances of survival.
Electrochemical Measurement of Interfacial Distribution and Diffusion Coefficients of Electroactive Species for Ion-Exchange Membranes: Application to Br2/Br− Redox Couple
Authors: Konev Dmitry , Istakova Olga , Vorotyntsev Mikhail
Published: October 2022

A novel method has been proposed for rapid determination of principal transmembrane transport parameters for solute electroactive co-ions/molecules, in relation to the crossover problem in power sources. It is based on direct measurements of current for the electrode, separated from solution by an ion-exchange membrane, under voltammetric and chronoamperometric regimes. An electroactive reagent is initially distributed within the membrane/solution space under equilibrium. Then, potential change induces its transformation into the product at the electrode under the diffusion-limited regime. For the chronoamperometric experiment, the electrode potential steps backward after the current stabilization, thus inducing an opposite redox transformation. Novel analytical solutions for nonstationary concentrations and current have been derived for such two-stage regime. The comparison of theoretical predictions with experimental data for the Br2/Br− redox couple (where only Br− is initially present) has provided the diffusion coefficients of the Br− and Br2 species inside the membrane, D(Br−) = (2.98 ± 0.27) 10−6 cm2/s and D(Br2) = (1.10 ± 0.07) 10−6 cm2/s, and the distribution coefficient of the Br− species at the membrane/solution boundary, K(Br−) = 0.190 ± 0.005, for various HBr additions (0.125–0.75 M) to aqueous 2 M H2SO4 solution. This possibility to determine transport characteristics of two electroactive species, the initial solute component and its redox product, within a single experiment, represents a unique feature of this study.
Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion
Authors: Kishimoto Ichiro , Ohashi Akio
Published: October 2022

The role of glucose effectiveness on postprandial hyperglycemia in daily life is not fully studied. Here, we examined the association between SgIo, an index of glucose effectiveness calculated from a 75 g oral glucose tolerance test, and the indices of hyperglycemia in obese/overweight men. SgIo was significantly associated with 1,5-anhydroglycitol, a biochemical marker for postprandial hyperglycemia. The receiver operating characteristic analyses of SgIo and oral disposition index for detecting the subjects with 1,5-anhydroglycitol < 14 μg/mL revealed that the areas under the curves were 0.77 and 0.76, while the cutoff points (sensitivity, selectivity) were 2.53 (0.9, 0.7) and 2.06 (0.36, 0.79), respectively. Both the SgIo < 2.53 category and the disposition index < 2.06 category were significantly associated with the percentages of meals with postprandial glucose levels ≥ 200 mg/dL, and the percentages of time when continuous glucose monitoring sensor readings were ≥200 mg/dL. After adjustment with disposition index, 45.5% of the subjects with the SgIo < 2.53 category had their 1,5-anhydroglycitol < 14 μg/mL, while, in the SgIo ≥ 2.53 category, 3.6% of the subjects had the hyperglycemia (p < 0.001). In addition, there were tendencies toward higher and lower SgIo quartile categories in subjects with walking (≥8000 steps) ≥60% of days and with noodle ingestion ≥20% of meals, respectively (p for trend, 0.008 and 0.038). In conclusion, lower glucose effectiveness is associated with postprandial hyperglycemia in the daily life of obese/overweight men, independently of insulin secretion. Lifestyles such as habits of walking and noodle ingestion are significantly associated with higher and lower glucose effectiveness, respectively.
Review of Optical Thermometry Techniques for Flows at the Microscale towards Their Applicability to Gas Microflows
Authors: Colin Stéphane , Fernández José M. , Barrot Christine , Baldas Lucien , Bajić Slaven , Rojas-Cárdenas Marcos
Published: October 2022

Thermometry techniques have been widely developed during the last decades to analyze thermal properties of various fluid flows. Following the increasing interest for microfluidic applications, most of these techniques have been adapted to the microscale and some new experimental approaches have emerged. In the last years, the need for a detailed experimental analysis of gaseous microflows has drastically grown due to a variety of exciting new applications. Unfortunately, thermometry is not yet well developed for analyzing gas flows at the microscale. Thus, the present review aims at analyzing the main currently available thermometry techniques adapted to microflows. Following a rapid presentation and classification of these techniques, the review is focused on optical techniques, which are the most suited for application at microscale. Their presentation is followed by a discussion about their applicability to gas microflows, especially in confined conditions, and the current challenges to be overcome are presented. A special place is dedicated to Raman and molecular tagging thermometry techniques due to their high potential and low intrusiveness.
A Portable, Negative-Pressure Actuated, Dynamically Tunable Microfluidic Droplet Generator
Authors: Trossbach Martin , de Lucas Sanz Marta , Seashore-Ludlow Brinton , Joensson Haakan N.
Published: October 2022

Droplet microfluidics utilize a monodisperse water-in-oil emulsion, with an expanding toolbox offering a wide variety of operations on a range of droplet sizes at high throughput. However, translation of these capabilities into applications for non-expert laboratories to fully harness the inherent potential of microscale manipulations is woefully trailing behind. One major obstacle is that droplet microfluidic setups often rely on custom fabricated devices, costly liquid actuators, and are not easily set up and operated by non-specialists. This impedes wider adoption of droplet technologies in, e.g., the life sciences. Here, we demonstrate an easy-to-use minimal droplet production setup with a small footprint, built exclusively from inexpensive commercially sourced parts, powered and controlled by a laptop. We characterize the components of the system and demonstrate production of droplets ranging in volume from 3 to 21 nL in a single microfluidic device. Furthermore, we describe the dynamic tuning of droplet composition. Finally, we demonstrate the production of droplet-templated cell spheroids from primary cells, where the mobility and simplicity of the setup enables its use within a biosafety cabinet. Taken together, we believe this minimal droplet setup is ideal to drive broad adoption of droplet microfluidics technology.
Electrical Modeling and Characterization of Graphene-Based On-Chip Spiral Inductors
Authors: Wang Da-Wei , Yuan Meng-Jiao , Dai Jia-Yun , Zhao Wen-Sheng
Published: October 2022

This paper investigates the electrical performance of graphene-based on-chip spiral inductors by virtue of a physics-based equivalent circuit model. The skin and proximity effects, as well as the substrate loss effect, are considered and treated appropriately. The graphene resistance and inductance are combined into the circuit model. It is demonstrated that the electrical characteristics of the on-chip square spiral inductor can be improved by replacing copper with graphene. Moreover, graphene exhibits more effectiveness in improving the inductance in tapered inductors than uniform ones.
Dual-Arm Visuo-Haptic Optical Tweezers for Bimanual Cooperative Micromanipulation of Nonspherical Objects
Authors: Tanaka Yoshio , Fujimoto Ken’ichi
Published: October 2022

Cooperative manipulation through dual-arm robots is widely implemented to perform precise and dexterous tasks to ensure automation; however, the implementation of cooperative micromanipulation through dual-arm optical tweezers is relatively rare in biomedical laboratories. To enable the bimanual and dexterous cooperative handling of a nonspherical object in microscopic workspaces, we present a dual-arm visuo-haptic optical tweezer system with two trapped microspheres, which are commercially available end-effectors, to realize indirect micromanipulation. By combining the precise correction technique of distortions in scanning optical tweezers and computer vision techniques, our dual-arm system allows a user to perceive the real contact forces during the cooperative manipulation of an object. The system enhances the dexterity of bimanual micromanipulation by employing the real-time representation of the forces and their directions. As a proof of concept, we demonstrate the cooperative indirect micromanipulation of single nonspherical objects, specifically, a glass fragment and a large diatom. Moreover, the precise correction method of the scanning optical tweezers is described. The unique capabilities offered by the proposed dual-arm visuo-haptic system can facilitate research on biomedical materials and single-cells under an optical microscope.
Antibacterial and Anti-Inflammatory Properties of Peptide KN-17
Authors: Zhang Qian , Yu Shuipeng , Hu Meilin , Liu Zhiyang , Yu Pei , Li Changyi , Zhang Xi
Published: October 2022

Peri-implantitis, an infectious disease originating from dental biofilm that forms around dental implants, which causes the loss of both osseointegration and bone tissue. KN-17, a truncated cecropin B peptide, demonstrated efficacy against certain bacterial strains associated with peri-implantitis. This study aimed to assess the antibacterial and anti-inflammatory properties and mechanisms of KN-17. The effects of KN-17 on oral pathogenic bacteria were assessed by measuring its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Moreover, the cytotoxicity and anti-inflammatory effects of KN-17 were evaluated. KN-17 inhibited the growth of Streptococcus gordonii and Fusobacterium nucleatum during in vitro biofilm formation and possessed low toxicity to hBMSCs cells. KN-17 also caused RAW264.7 macrophages to transform from M1 to M2 by downregulating pro-inflammatory and upregulating anti-inflammatory factors. It inhibited the NF-κB signaling pathway by reducing IκBα and P65 protein phosphorylation while promoting IκBα degradation and nuclear P65 translocation. KN-17 might be an efficacious prophylaxis against peri-implant inflammation.
Whole-Genome Sequence Comparisons of Listeria monocytogenes Isolated from Meat and Fish Reveal High Inter- and Intra-Sample Diversity
Authors: Murr Larissa , Huber Ingrid , Pavlovic Melanie , Guertler Patrick , Messelhaeusser Ute , Weiss Manuela , Ehrmann Matthias , Tuschak Christian , Bauer Hans , Wenning Mareike , Busch Ulrich , Bretschneider Nancy
Published: October 2022

Interpretation of whole-genome sequencing (WGS) data for foodborne outbreak investigations is complex, as the genetic diversity within processing plants and transmission events need to be considered. In this study, we analyzed 92 food-associated Listeria monocytogenes isolates by WGS-based methods. We aimed to examine the genetic diversity within meat and fish production chains and to assess the applicability of suggested thresholds for clustering of potentially related isolates. Therefore, meat-associated isolates originating from the same samples or processing plants as well as fish-associated isolates were analyzed as distinct sets. In silico serogrouping, multilocus sequence typing (MLST), core genome MLST (cgMLST), and pangenome analysis were combined with screenings for prophages and genetic traits. Isolates of the same subtypes (cgMLST types (CTs) or MLST sequence types (STs)) were additionally compared by SNP calling. This revealed the occurrence of more than one CT within all three investigated plants and within two samples. Analysis of the fish set resulted in predominant assignment of isolates from pangasius catfish and salmon to ST2 and ST121, respectively, potentially indicating persistence within the respective production chains. The approach not only allowed the detection of distinct subtypes but also the determination of differences between closely related isolates, which need to be considered when interpreting WGS data for surveillance.