bluuebunny/crossref_metadata_2025 huggingface dataset:
ТОРГІВЛЯ ЛЮДЬМИ: СУЧАСНИЙ СТАН, ДИНАМІКА ТА НАПРЯМИ ПРОТИДІЇ
Authors: Сперкач Н. А.
Published: December 2023

У статті досліджується сучасний стан, динаміка та напрями протидії торгівлі людьми. Визначається, що в Україні торгівля людьми з початком війни ще більше загострилась, адже значна кількість людей з країни примусово вивезена країною-агресором на територію росії та білорусі, також досить складна економічна ситуація, корупція, високий рівень безробіття, поширення зовнішньої трудової міграції, диспропорції розвитку ринку праці, поширеність шахрайських схем вербування громадян, активізація діяльності міжнародних злочинних угруповань, недосконалість законодавства, правова необізнаність населення та інші фактори ризику призводять до потрапляння в ситуацію торгівлі людьми.

Особливої актуальності проблема торгівлі людьми набула в контексті повномасштабної війни, адже вона стала одним із тяжчих наслідків для українського суспільства, враховуючи той факт, що мільйони людей, які були змушені евакуюватися чи за кордон, чи просто на інші території, або ті, яких примусово вивезли на територію країни-агресора, стали потенційними жертвами з високим рівнем віктимності. Саме, тому у статті досліджено напрями координації дій щодо протидії торгівлі людьми на всіх рівнях, комплексного системного підходу та швидкого реагування на потенційну загрозу чи фактичну ситуацію, що може забезпечити належний рівень соціального захисту населення та вберегти від можливих ризиків торгівлі людьми.

У статті автором наведено статистичні дані щодо зареєстрованих кримінальних правопорушень у сфері торгівлі людьми, кількості осіб, що вчинили це правопорушення, наводиться загальна кримінологічна характеристика торгівлі людьми в Україні за останні роки, а також опрацьовані статистичні дані Національної соціальної сервіс­ної служби України щодо осіб, яким надано статус постраждалих від торгівлі людьми.

Також досліджено напрями співпраці України з Міжнародною організацією міграції та іншими партнерами щодо превентивних заходів для протидії торгівлі людьми, а також координаційних дій Міграційної поліції з європейськими партнерами щодо створення європейської платформи з обміну інформації про торгівлю людьми.

На основі проведеного наукового дослідження проблематики торгівлі людьми виокремлені конкретні дієві напрями протидії цього кримінального правопорушення. Зазначено, що на рівні держави, міжнародних організацій та громадянського суспільства повинна бути повна та дієва консолідація зусиль як органів державної влади, так і органів місцевого самоврядування, а також громадських організацій та громадян щодо запобігання торгівлі людьми. Відмічено, що досить важливим і першочерговим завданням є забезпечення ефективної, належної, актуальної протидії таким кримінальним правопорушенням шляхом спільного реагування та скоордино­ваних дій усіх відповідних суб’єктів, адже свобода людини є однією з головних цінностей сучасного цивілізованого суспільства, а забезпечення її недоторканності – однією з основних функцій держави.
Optimizing Spinal Fusion in Degenerated Spinal Stenosis, proposing a hybrid scoring system for Bangladesh people in law Sack pain
Authors: Rahman Md Moshiur , Rahman Sabrina , Hossain Mohammad Nabil , Khan Robent Ahmed , Khan Sim Khairun Nabi , Sarwar ASM
Published: December 2023

Background: Degeneration is a progressive phenomenon in lumbar spinal stenosis patients. The outcome of surgery predictors is sometimes biased. Fusion and stabilization in such cases are unnecessary in many situations. There is still a debate to decompress only versus fusion in low-grade listhesis. Fusion and stabilization in the aged lumbar spine should have clear indications.
Objective: To assess whether the fusion is necessary in lumbar spinal stenosis in selected cases or not and to create a new scoring system among the patients of low backache in Bangladeshi people.
Method: A total of 120 cases were observed retrospectively from 2012 to 2018 in Comfort Hospital, Dhaka, Bangladesh. And 40 more cases data will be collected in the upcoming study period of 6 months. To assess the study we will conduct a survey. In previous cases, the patients had undergone three types of surgeries (Laminectomy, Unilateral approach, and Fusion surgeries). ODI and Swiss score were used for assessment of functional outcome. A new scoring system has been made for patients who may be benefited from fusion or non- fusion surgeries.
Results: In retrospective data, there were 80 male and 40 female patients. Maximum patients were between 41 to 50 years. 59.17% were heavy workers and 66.67% were smoker. Maximum patients (59.17%) had undergone unilateral surgical approaches and 18.33% undergone fusion surgeries. 98.33% patients had satisfactory outcome in our study. In our hybrid scale, the pain status showed, 52.50% had moderate pain, 22.50% had mild pain, 20% had severe pain and only 5% had very severe pain. Maximum participants having low back pain were below 30 years old and 65% lift weight more than 25 kg. The total pain score was significant in our correlation test. The Cronbach's Alpha (.784) was significant in Bangladeshi socio- demographic population.
Conclusion: The outcome of such a study will help to know either fusion surgeries in selected cases are effective for lumbar spinal stenosis or not. Also, it will probably help to select patients for such a study and to improve surgical treatment methods.
Bangladesh Med Res Counc Bull 2023; 49: 164-170
Restitución de bienes culturales y estatuas no deseados: desafíos para los museos
Authors: Chuva Marcia
Published: December 2023

El texto aborda dos problemas que configuran la agenda global actual: las demandas de restitución del patrimonio cultural y las intervenciones en estatuas indeseables en el espacio público. Los dos temas se entrelazan aquí en una reflexión sobre las funciones del museo. Cuestiona el papel de los museos hoy, reflexionando sobre diferentes posibilidades para su descolonización.
Peningkatan Keterampilan Bidan dalam Pelayanan Komunitas dengan Terapi Prenatal Massage With Love di Wilayah Pesisir Kota Bengkulu
Authors: Dewiani Kurnia , Yetti Purnama  , Linda Yusanti
Published: December 2023

In general, discomfort during pregnancy is back pain, cramps, and leg swelling. The unpleasantness is also prone to occur in pregnant women who are in coastal areas. The low economic situation makes pregnant wives work to help support the family income. The use of drugs is not suggested to overcome maternal complaints. The research results show how to overcome the problem by doing a prenatal massage with love. The aim is to apply prenatal massage with love to increase the quality of pregnancy care services in the community, especially in the coastal area of Bengkulu City. Training midwives implemented the method in the designated target area. This research-based service involves lecturers, students, and midwives in the coastal area of Bengkulu City, both those stored in the Puskesmas and the Independent Midwife Practice (PMB) owner. The results of the activity objectives and plans have been achieved and run smoothly. The conclusion is that the community's skills and quality of service are following the target, namely 80%, reducing discomfort in the form of back pain, leg swelling, and leg cramps in pregnant women 75% on visits to midwives. Improvement of at least 25% of midwives' ability to conduct entrepreneurship to develop community practice.
The Impact of Training Methods and Leg Muscle Strength to the Long Jumping Squat Style Skills of SMA Pesantren Pancasila Bengkulu
Authors: Defliyanto  , Moch. Asmawi  , Hernawan Hernawan
Published: December 2023

The purpose of this study was to determine the impact of the Training methods (Plyometrik and Weight Training ) and in terms the high strength of leg muscle and the low strength of leg muscle. Based on the problems, the design of this study was the treatment by the level of 2 x 2. Analysis of variance between the group at a significant level α = 0.05. This study also aims to determine the interaction between exercise and leg muscle strength against to the long jumping squat style skills.This study was done in SMA Pesantren Pancasila, Bengkulu. The sample was consisted of 24 athletes in this study, then divided into four groups, each group consisting of 6 athletes which as the object of this study.The data analysis technique was the analysis of variance of two lanes and then followed by Tukey test with significance level α = 0.05. The results of this study indicate that (1) Overall, the results of long jumping skills to the group that trained with exercise methods of Plyometrik better than the group trained with the type of Weight  Training, (2) There are interactions between the Training methods with leg muscle strength to the results of Long Jumping Squat Style Skills, (3) For those athletes who have high leg muscle strength, the result of long jumping skills through the implementation of exercise methods Plyometrik better than the method of Weight  Training, (4) For those athletes who have low leg muscle strength, the result of long jumping skill through the implementation of Weight Training methods not better than the Training methods of Plyometrik.
Analysis of Sport Massage and Personal Trainers New Economic Opportunities
Authors: Anam Khaerul , Muhammad Riyan Hidayatulloh  , Lalu Moh Yuda Isnaini  , Lalu Mardani Arinaza
Published: December 2023

Sport massage and personal trainers are new steps in creating growth opportunities for the Creative Economy, the New Economy that transforms ideas and creates opportunities. The aims of this study are: 1) to determine the relationship between sports massage services and personal trainers to achieve health and fitness goals; 2) To find out what's the economic impact of increasing demand for sports massage services and personal trainers is. 3) To find out How consumer behavior changes when choosing between sports massage and personal training and how this affects the market. 4) To find out the role of sport massagers and personal trainers in driving business growth in the fitness industry. Methods of data analysis using descriptive percentages The sample population in this study was 50 people. The results showed that. 1) The relationship between sports massage services and personal trainers to achieve health and fitness goals 90% answered is very influential. 2) To find out what the economic impact of increasing demand for sports massage services and personal trainers is. 90% answered very impactful. 3) To find out how consumer behavior changes when choosing between sports massage and personal training and how this affects the market. 90% answered very influential. 4) To find out the role of sport massagers and personal trainers in driving business growth in the fitness industry 100% is very encouraging. The conclusion of this study is that 93% of sports massage and personal trainers can create a new economy. The message is that it is hoped that Physical Education students will be increasingly equipped with skills in dealing with opportunities.
Table Tennis Forehand Drive Learning Model for Application based Elementary School Students
Authors: Agus Kurniadi  , Hernawan Hernawan , Sri Nuraini
Published: December 2023

This research produces a learning model for table tennis forehand drive strokes for upper elementary school students and tests the effectiveness of an application-based table tennis forehand stroke skill model for upper elementary school students. The research approach and method for this table tennis Forehand drive stroke skill learning model uses the ADDIE (Analysis, Design, Development, Implementation and Evaluation) research and development model. The subjects involved in this research were 34. The subjects of this research were upper elementary school students. The data analysis technique was created by conducting a pretest and posttest using a forehand drive stroke skill movement instrument. The results are analyzed, the point is to find out whether there is a percentage increase in skills through the learning model given to students. Based on the results of the analysis, it was found that there was an increase in the ability of table tennis forehand drive strokes for elementary school IV students after implementing the forehand drive movement learning model. The results obtained were 6.41% pre-test and 8.65% post-test.
Development of Teaching Materials with Thunkable Applications to Support Blended Learning in Tennis
Authors: Raibowo Septian , Pujianto Dian
Published: December 2023

This research aims for the future to facilitate Physical Education Study Program students with various teaching materials to support blended learning. Learning. Especially teaching materials that help students' cognitive learning. Because it is known that nowadays and with the sophistication of technology, learning can be done anywhere and at any time by students. In fact, this also makes the college learning process easier because having teaching materials as a learning resource for students can help learning in lectures become more effective and efficient. Because having additional teaching materials as a student learning resource will enrich student knowledge. Specifically for this research, teaching materials will be developed using the Thunkable Tennis Court application. In the future, there will be gradual development for other types of teaching materials and other materials as well. As is known, the physical education study program is closely related to learning movement. Learning to move yourself is also divided into several stages which include cognitive, associative and automatic stages. The cognitive stage is the beginning and basis that influences success at other stages. Because it is necessary for an educator to provide effective and efficient learning at this stage and provide enrichment of knowledge to students by using up-to-date teaching materials in accordance with current developments. The method to achieve this goal will be Research and Development from year to year. What is certain is that the Research and Development stage begins with needs analysis, product development, validation, testing and publication.
Push Up Exercise Against 50 Meter Swimming Speed Breaststroke
Authors: Nazilah Nikmatun , Aryanti Silvi , Victorian Ahmad Richard
Published: December 2023

The aim of this study was to evaluate the influence of push-up training on improving the speed of breaststroke swimming in athletes who are members of the Palembang Tirta Sriwijaya Aquatic Club (TSAC). This study was conducted as an experiment using a one-group pretest and posttest research design. The research subjects included athletes who are part of the Palembang Tirta Sriwijaya Aquatic Club (TSAC). The research sample involved all members of age group III with an age range of 12-13 years consisting of 30 individual athletes. The tool used to measure variables is the breaststroke swimming test using a distance of 50 meters. The data analysis was conducted utilizing the T-test. Based on the analysis results, the t-value exceeded 4.762, while the t-table value was 2.045. These results indicate a significant difference between the pretest push-up and posttest push-up groups in relation to the improvement in 50-meter breaststroke swimming speed. The conclusion of this study revealed that push-up exercises had a positive impact on increasing breaststroke swimming speed as far as 50 meters.
A Study on Semiotic Analysis of New Media Art as Spatial Art: Focusing on the Works of Jeffrey Shaw, Tamas Waliczky, Christa Sommerer, Laurent Mignonneau, and Miroslaw Rogala
Authors:   The Korean Society of Culture and Convergence, Chu EunYoung
Published: December 2023

The artistic symbolism of new media art is closely related to its concept and is based on the regulations on socially used symbols. To explore the new possibilities of new media art as modern engineering art, we first summarize the semiotics theories of Saussure and Barthes and then analyze the works of Shaw, Waliczky, Sommerer, Mignonneau, and Rogala, representative new media artists since the 1960s, based on Barthes’s theory of the Text. The works of Shaw and Waliczky aim to expand space in new media by forming a new tactile space with the participation of visitors. The works of Sommerer and Mignonneau create virtual spaces led by visitors to induce space expansion through integration within the work. The works of Rogala promote the formation of a closely related space by the gap between the dinotation where the inner deformation takes place and the space created by the movement of the visitors. This kind of semiotic analysis of artworks can help expand the breadth of analysis in the field of media art and build another foundation for creation.
Ancient Chinese Cultural Ideas Reflected in Chinese Characters Associated with Wishes for Good Luck
Authors:   The Korean Society of Culture and Convergence, Lee Inkyung
Published: December 2023

This study was conducted by focusing on the fact that the Chinese character related to prayer for good luck in the radical '示' of “Shuowenjiezi(說文解字)” is not only the most distributed, but also placed at the very front. In this paper, we looked at ancient Chinese ancestral rite customs and cultural ideas reflected in ‘禮’ and ‘福’ before analyzing Chinese characters related to prayers for good fortune. Since '福' bestowed by the gods can only be achieved by avoiding '禍', this study conducted research by selecting 12 Chinese characters related to '福' and 8 Chinese characters related to '禍' as the Chinese characters related to blessings and blessings. Chinese characters related to wishes for good luck include '祿', '禠', '祥', '祉', '禎', '禧', '祺', '祗', '禛', '禔', It means God's protection, good omens and peace of life. ‘祈’ and ‘禱’ mean to pray for good fortune. In addition, the Chinese characters related to ‘禍’ include ‘禍’, ‘祟’, and ‘䄏’ to mean disaster imposed by God, ‘祓’, ‘’, ‘禜’, ‘禳’ and ‘禬’ to mean escape from disaster.
Analysis of Field Music in Response to In-Game Temporal and Spatial Changes: A Case Study on The Legend of Zelda: Tears of the Kingdom
Authors:   The Korean Society of Culture and Convergence, Kim Iyn , Hong Sungkyoo
Published: December 2023

Adaptive music, evolving nonlinearly with in-game situations, has swiftly progressed since the advent of audio middleware in the 1990s. As a pivotal component alongside visuals, it enhances player experiences, adding depth to narratives and gameplay, fostering immersion. This study analyzes adaptive music generation methods, proposing effective techniques using 'The Legend of Zelda: Tears of the Kingdom' as a case study. Field music changes in different game areas were analyzed based on in-game time and player character location. Results showed that 'Tears of the Kingdom' employs methods of randomly rearranging harmonious audio elements and introducing arbitrary playback timing differences. These resource-efficient methods can be effectively applied on storage-constrained platforms like portable gaming devices or mobile platforms.
A Comparative Analysis Study on Musical Characteristics Shown in the Use of Modes in Korean and Chinese Classical Drama OSTs: Focusing on the Analysis of the Theme Melody of Major Underscores
Authors:   The Korean Society of Culture and Convergence, Xiang Meng , Han Kyung Hoon
Published: December 2023

The purpose of this paper is to understand the musical features in the use of modes in Korean and Chinese classical drama OSTs, with the intention of providing assistance to music creators who wish to produce OSTs for classical dramas. To achieve this, we explore the overall musical flow of classical drama OSTs, focusing on the analysis of the main insert songs' thematic melodies. In order to grasp the commonalities and differences, we analyze the thematic melodies of key insert songs, covering the period from 2020 to 2023, selecting the top 12 OST songs from dramas that entered the top 3 viewership rankings in Korea and China. As a result, commonalities and differences in the musical characteristics of OSTs from classical dramas in Korea and China were identified. It is hoped that this will contribute to exploring ways to utilize classical drama OST production and serve as valuable information and foundational material for the development of drama music genres.
Cultural Characteristics and Social Values of Mongolian Folk Dance: Focusing on the Dance Drama “The Cavalry”
Authors:   The Korean Society of Culture and Convergence, Shen Bingyan , Kim Kyunghoi
Published: December 2023

This study focused on the Mongolian national dance drama 'Cavalry' to trace the roots of Mongolian national culture and to examine its historical background. It analyzed the ethnic elements of the dance drama 'Cavalry' and reviewed the diversity of Mongolian culture as depicted in the drama. Finally, the study examined the value of Mongolian national dance culture as depicted in 'Cavalry' and its impact on society. The results revealed that Mongolian national dance goes beyond just being a form of dance, playing a significant role in the derived cultural values, contributing to the transmission and development of national culture. This research is expected to contribute to existing studies on the transmission and development of Mongolian national dance culture.
Research Trend Analysis on Assessment of Online Korean Education
Authors:   The Korean Society of Culture and Convergence, Jeon Daeil
Published: December 2023

This paper attempted to examine the part of the evaluation of online Korean language education that took place during the pandemic when non-face-to-face classes were activated and to identify the trends and trends of research at the same time. Research on online Korean language education evaluation began in 2006, when the influx of foreigners was active, and various big data analysis methods were used to draw conclusions and gain insight into educational research trends. 88 academic papers were searched through the RISS (Research Information Sharing Service), and the extracted word parts were limited to nouns, and frequency analysis, centrality analysis (degree centrality, close centrality, betweenness centrality), and topic modeling were conducted to derive results and discuss them.
The Effect of Group Art Therapy with Loving-Kindness Meditation on Self-compassion and Job Stress of Childcare Teacher
Authors:   The Korean Society of Culture and Convergence, Oh Kayoung
Published: December 2023

The purpose of this study is to verify the effect of group art therapy combined with loving-kindness meditation on self-compassion and job stress of childcare teachers. The subjects of the study were 12 childcare teachers in J City who reported experiencing job-related stress (6 in the experimental group, 6 in the control group). Art Therapy was held once a week from July to August 2022, for a total of 8 sessions, 80 minutes each. The results of the self-compassion scale and job stress scale for the experimental and control groups before and after implementing the program are as follows. As follows. First, the experimental group's overall self-compassion, self-kindness, universal humanity, and mindfulness abilities were found to have improved. Second, the experimental group's job stress related to overall job stress, unsupportive work environment, peer teacher relationship, and parent relationship decreased. Therefore, the possibility of using loving-kindness meditation and group art therapy as psychological treatment for teachers in childcare settings was confirmed.
Helplessness of Preservice Special Education Teachers in Academic Settings
Authors:   The Korean Society of Culture and Convergence, Oh Hyerim
Published: December 2023

This study explored the characteristics of academic helplessness among pre-service special education students. Through written interviews, the study collected experiences of academic helplessness from 15 students majoring in elementary special education at a teachers' college. Phenomenological methods were utilized to analyze the gathered data. The analysis identified 25 meaning units that were categorized into 7 sub-themes. These included discrepancy between expectations and reality regarding academic achievement, social maladjustment in university life, overemphasis on external assessments. diminished focus and motivation for learning due to declining physical health, seeking external support upon recognizing helplessness, accepting environmental constraints and one’s own limitations, and re-exploring learning motivation and goals. These themes highlight the uncontrollable challenges students encounter in various adverse situations and the strategies they adopt to manage them. The findings provide implications and recommended further research directions for enhancing special education teacher training courses.
A Study on the Practical Humanities Potential of Music Humanities
Authors:   The Korean Society of Culture and Convergence, Jeon Seonkoo
Published: December 2023

This study proposed Music Humanities as a methodological model for the social realization of practical humanities. Music humanities is text-based journalistic content based on a convergent approach between the fields of music and humanities.. In order to examine the possibility and usefulness of practical humanities implied in Music Humanities, based on interpretive research methods based on grounded theory of the text of Music Humanities and related research literature, first, text recognition according to discussion system restructuring We analyzed the text linguistics and social psychological standards and values reflected in the environment construction process, and derived practical humanities significance through them. Second, the musicological value of key text areas according to the structuring of music's media nature was illuminated and the practical humanities implications implied in the conceptualization process of music were derived. Lastly, the possibility of creating social messages in the humanities through music was specified by analyzing the discourse process of key text areas that surfaced the humanities value of music. This study can provide an opportunity to further solidify the social tone and line of practical humanities.
Evaluation of Approaches for Correcting the State of Animals under Debilitating Physical Exertion by Cellular and Genetic Biomarkers
Authors: Karkischenko V. N. , Pomytkin I. A. , Petrova N. V. , Vasil’eva I. A. , Alimkina O. V. , Stankova N. V. , Laryushina N. A.
Published: December 2023

In this work, we investigate the effect of a number of pharmaceutical preparations on the expression of genes, which are used as molecular targets under the conditions of debilitating physical exercise in minipigs. In the conducted experiment, the effectiveness of the following preparations was compared: “Mio-Activ-Sport” dietary supplement, a liposomal deer musk extract, intranasal insulin, and a liposomal ginseng preparation. The selected biomarkers included the leukocyte blood fraction and mRNA expression of NFE2L2 and HMGB1 genes in lymphocytes. Among the studied preparations, the liposomal deer musk extract showed the highest effectiveness. Thus, during seven days of therapy, this preparation almost completely prevented the pro-inflammatory effect of physical load. At the same time, the liposomal deer musk extract led to a manyfold increase in the expression of NFE2L2 gene, which is responsible for antioxidant defense of the organism. In terms of action, the liposomal deer musk extract outperformed insulin – the reference drug, whose protective effects are well known from the scientific literature. These findings confirm the prospects of deer musk preparations for medical rehabilitation.
Review of "Physiological psychology" by Vladimir E. Trajkovski
Authors: Ivanovska Andrea
Published: December 2023

“Physiological psychology” authored by Prof. Dr. Vladimir E. Trajkovski, represents a pivotal contribution to the field of physiological psychology. The Publisher is Faculty of Philosophy in Skopje and it was published on September 29th in Skopje. This is first edition of the book, which is printed in B5 format with ISBN 978-608-238-235-7.
This textbook, the first in the Macedonian language, elaborately explores the biological bases of behaviour. The book's scope extends beyond mere academic interest, serving as a valuable resource for students and professionals.
This book is a valuable resource for anyone fascinated by the intersection of psychology and physiology, demystifying how our biological mechanisms shape behaviour. It's a great educational resource, particularly for students and professionals in psychology, neuroscience, and similar fields, because of its exhaustive exploration of physiological psychology. From the workings of the sensory systems and the dynamism of motor functions to the neurological and cognitive complexities, the book clarifies human behaviour's roots. This book is a great candidate for readers seeking to enhance their knowledge of physiological psychology.
The Spark of a Future Anterior: An Archaeology of Entoptic Media
Authors: Benjamin Jesse Josua
Published: December 2023

Published version here: https://www.sum.si/journal-articles/the-spark-of-a-future-anterior-an-archaeology-of-entoptic-media ----- In this semi-fictional journal article for ŠUM, I construct a historical review of the shift from an optic to an entoptic media regime, located in the development of information technology principles from symbolic to subsymbolic pattern inference and representation. Drawing from a mixed fictional archive from an imaginary department of the Yugoslavian computing technology firm Iskra Delta, I create research diagrams that show the principle components behind that shift, focussing on issues of symbolic representation and technological mediation.
Pemanfaatan Bahan Alam untuk Pemeliharaan Kesehatan di Desa Seleman Kecamatan Danau Kerinci
Authors: Rizky Yulion Putra  , Anggraini Gusnia , Ridha M Sa'id , Fitri Nadia , Nurfazila Nurfazila , Rahmadina Rahmadina , Kholilawati Nelly , Sari Wanti Puspita
Published: December 2023

Health problems are still the main problems in Seleman Village, including diabetes, hyperlipidemia, gout, myalgia, and hypertension. This community service aims to improve the health and knowledge of residents in using medicine correctly and can utilize herbal plants as alternative treatments that can also be used as business opportunities. The methods used are counseling and demonstration as well as giving leaflets/brochures. This activity was carried out in the Seleman Village area. The target of counseling is the residents of Seleman Village with a total of 161 residents. From the pre-test results, 49.3% knew about hypertension, 40.42% knew about cholesterol, 56.78% knew about diabetes, and 51.87% knew about gout. After conducting educational activities about the disease, 95.34% knew about hypertension, 97.34% knew about cholesterol, 96.55% knew about diabetes, and 96.44% knew about gout. It can be concluded that from the community service carried out there is an increase in public knowledge on how to use medicine and independent use of herbal plants as alternative treatments derived from nature or known as "back to nature".
Deteksi Dini Kanker Payudara dengan Teknik SADARI pada Siswi SMK Negeri 1 Tolitoli
Authors: Hasni Hasni , Evie Sova
Published: December 2023

Cancer that is detected early has the possibility to get better treatment. The problem of breast cancer is even bigger because more than 70% of sufferers come to the doctor at an advanced stage, therefore it requires special treatment. Breast cancer can be found early with a BSE examination. BSE is very important because almost 85% of breast lumps are found by sufferers themselves. The purpose of this Community Service is to increase the knowledge of students at SMK Negeri 1 Tolitoli Regency about early detection of breast cancer using the BSE technique. Methods used include lectures, questions, answers, discussions, and demonstrations of BSE techniques. The targets were 55 female students at SMK 1 Negeri 1 Tolitoli. From the results of the post-test carried out, it was found that the average knowledge of female students increased from 40 to 80. As for the behavior in the pretest, it was found that T Mean during the post-test. It can be concluded that there is an increase in knowledge and behavior changes in female students after education.
Pemeriksaan Kadar Gula Darah Sewaktu pada Remaja di SMAN 7 Denpasar
Authors: Laksmita Saka , Apriyanthi Desak Putu Risky Vidika , Widayanti Ni Putu , Aryasa Wayan Tanjung , Artini Ni Putu Rahayu , Iriani Yulidia
Published: December 2023

People in urban areas tend to have unhealthy lifestyles, especially teenagers. This can trigger various diseases. Health status needs to be considered from an early age, especially paying attention to the intake of sugar in the body. Excess sugar levels in the blood are one of the causes of diabetes mellitus. Measurement of blood sugar (GDS) in adolescents of SMAN 7 Denpasar aims to screen for Diabetes Mellitus (DM) to detect this disease early. The method is done by checking the blood sugar test (GDS), weight, and height. The results of the blood sugar test in this community service activity showed that out of 50 students with a ratio of male and female percentages of 40% and 60% respectively, only 4% were identified with low blood sugar levels while the remaining 96% had normal blood sugar levels. The conclusion of the community service at SMAN 7 Denpasar is that most of the students have normal blood sugar levels.
PENENTUAN WAKTU STANDAR PADA JASA LAUNDRY DRY AND CLEANING DI PT XYZ
Authors: Sari Tri Novita , Arifiya Nur , Nurfida Anita , Hermawan Reza
Published: December 2023

Technological advances make it easier for every human being to carry out daily activities, one example of which is washing. PT XYZ is a company engaged in dry and cleaning laundry services which offers washing and ironing services for hotels. Punctuality of service is one of the keys to success at PT XYZ. The variation in the number of orders means that PT XYZ must set a standard time or standard time, so that timely service can be maintained. Measuring working time is an estimate of the time that will be used in a job. Work measurements are carried out directly using the stopwatch time study method to obtain standard time. Based on research, it was found that the standard time for the washing process until the distribution of laundry results to each hotel was 29 hours 17 seconds
A novel optimal formula of nickel extraction: arsenic removal from niccolite by controlling arsenic-containing phases
Authors: Tang Xiaowei , He Yuehui
Published: December 2023

Objective: Niccolite, a rare nickel arsenide mineral, has emerged as a promising source for nickel extraction. However, its processing is limited and often associated with toxicity concerns. This study aims to search for efficient separation of arsenic during the roasting process of niccolite.

Methods: The arsenic-containing phase was optimized through changing the contents of oxygen, additive S, and additive FeS in the system to achieve efficient separation of arsenic during the roasting process of niccolite. Thermodynamic analysis was performed using the equilibrium composition module with HSC Chemistry.

Results: The thermodynamic results showed that in direct roasting, the product contained ferric arsenate which immobilized arsenic in the solid phase, increasing the difficulty in separation. In the presence of sulfur, the arsenic may escape completely in the form of gas (As2O3, As4O4, As4O6). The use of FeS as the reductant significantly reduced the residual arsenic content.

Conclusion: The FeS reduction in roasting process is an optimal strategy for arsenic removal from niccolite. This provides a novel technique for nickel extraction in industry.
Thoracic endovascular aortic repair for type B aortic dissection with aberrant right subclavian artery: a single-center retrospective study
Authors: Zeng Yanzhang , Yuan Ping , He Qiang
Published: December 2023

Objective

To evaluate the outcomes of thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD) with aberrant right subclavian artery (ARSA).

Methods

A retrospective analysis was conducted on patients with TBAD and ARSA who underwent TEVAR between the period of January 2017 and December 2022. Patient demographics, computed tomography angiography (CTA) measurements, surgical procedures, and postoperative outcomes were reviewed.

Results

A total of 9 patients (6 males and 3 females) were included in the study. 4 ARSA were reconstructed, 3 by periscope technique and 1 by in vitro fenestration technique. 3 left subclavian arteries (LSA) were reconstructed, 1 by the chimney technique and 2 by the single-branched stent technique. 2 patients underwent reconstruction of both ARSA and LSA. The overall technical success rate was 100%, with no occurrences of stroke, paraplegia, or mortality within 30 days. 1 patient experienced immediate type Ia endoleak, which resolved after 3 months. 1 patient developed weakness in the right upper limb, while 1 patient presented mild subclavian steal syndrome (SSS); both cases showed recovery during follow-up. The average follow-up duration was 35.6 ± 11.1 months, during which no reinterventions, deaths, or strokes were observed.

Conclusion

Our limited experience involving 9 patients demonstrates that early and mid-term outcomes of TEVAR for the treatment of TBAD with ARSA are satisfactory.
ROS regulation in gliomas: implications for treatment strategies
Authors: Yang Yu-Chen , Zhu Yu , Sun Si-Jia , Zhao Can-Jun , Bai Yang , Wang Jin , Ma Li-Tian
Published: December 2023

Gliomas are one of the most common primary malignant tumours of the central nervous system (CNS), of which glioblastomas (GBMs) are the most common and destructive type. The glioma tumour microenvironment (TME) has unique characteristics, such as hypoxia, the blood-brain barrier (BBB), reactive oxygen species (ROS) and tumour neovascularization. Therefore, the traditional treatment effect is limited. As cellular oxidative metabolites, ROS not only promote the occurrence and development of gliomas but also affect immune cells in the immune microenvironment. In contrast, either too high or too low ROS levels are detrimental to the survival of glioma cells, which indicates the threshold of ROS. Therefore, an in-depth understanding of the mechanisms of ROS production and scavenging, the threshold of ROS, and the role of ROS in the glioma TME can provide new methods and strategies for glioma treatment. Current methods to increase ROS include photodynamic therapy (PDT), sonodynamic therapy (SDT), and chemodynamic therapy (CDT), etc., and methods to eliminate ROS include the ingestion of antioxidants. Increasing/scavenging ROS is potentially applicable treatment, and further studies will help to provide more effective strategies for glioma treatment.
Development of a quadruplex PCR amplicon next generation sequencing assay for detection and differentiation of Bartonella spp.
Authors: Bai Ying , Osikowicz Lynn M. , Hojgaard Andrias , Eisen Rebecca J.
Published: December 2023

The genus Bartonella includes a group of species that are associated with a wide range of mammalian species, including human. It is challenging to detect all Bartonella species using a single molecular target due to its high genetic diversity. To solve this issue, we developed a quadruplex PCR amplicon sequencing assay using next-generation sequencing (NGS) technology for the detection and differentiation of Bartonella species. Our objective was to obtain the specific sequences of a minimum of two of the four target genes as confirmation of the identity of a particular Bartonella species using the assay. Four pairs of primers targeting specific regions on gltA, groEL, rpoB, and ssrA were evaluated for their capability of differentiating Bartonella species individually and collectively by performing singular PCR amplicon sequencing and quadruplex PCR amplicon sequencing. Using the quadruplex PCR amplicon sequencing, 24 Bartonella reference species were tested, all of which were successfully differentiated by at least two targets. Bartonella species were accurately identified from the artificially mixed DNA templates developed to simulate coinfections. The limit of detection was determined to be 1 fg based on testing a series of 10-fold dilutions of DNA from the Bartonella species. Testing of high DNA concentrations of 19 non-Bartonella species showed high specificity with none of the non-Bartonella species misclassified as Bartonella. Finally, the assay was evaluated by testing DNA extracts from field-collected body lice (Pediculus humanus humanus) and Norway rats (Rattus norvegicus): Bartonella quintana was detected and confirmed by three targets in the lice and Bartonella tribocorum was detected and confirmed by two targets in the rats. These results demonstrated that Bartonella species could be accurately and rapidly detected and differentiated into different tissue types using the quadruplex sequencing assay.
Molecular epidemiology and virulence of goose astroviruses genotype-2 with different internal gene sequences
Authors: Xu Linhua , Jiang Bowen , Cheng Yao , Gao Zhenjie , He Yu , Wu Zhen , Wang Mingshu , Jia Renyong , Zhu Dekang , Liu Mafeng , Zhao Xinxin , Yang Qiao , Wu Ying , Zhang Shaqiu , Huang Juan , Ou Xumin , Gao Qun , Sun Di , Cheng Anchun , Chen Shun
Published: December 2023

Goose astrovirus (GAstV) is a small, non-enveloped, single-stranded, positive-sense RNA virus. GAstV has rapidly spread across various regions in China since 2016. In Sichuan, out of 113 samples were collected from goose diseases between 2019 and 2022, 97 were positive for GAstV through PCR testing. Remarkably, over the past three years, GAstV outbreak in Sichuan has accounted for an astonishing 85.8% of all goose-origin viruses. Among these cases, 63.9% had single GAstV infections, 29.9% had dual infections, and 6.2% had quadruple infections. To comprehend the variations in virulence among distinct strains of GAstV. 12 representative strains of single GAstV infections were isolated. These strains exhibited distinct characteristics, such as prominent white urate depositions in organs and joints, as well as extensive tissues phagocytosis in major target organs’ tissues. The conserved ORF1b genes and the variable ORF2 genes of these representative GAstV strains were sequenced, enabling the establishment of phylogenetic trees for GAstV. All GAstV strains were identified as belonging to genotype-2 with varying internal gene sequences. Experiments were conducted on GAstV genotype-2, both in vivo and in vitro, revealed significant variations in pathogenicity and virulence across susceptible cells, embryos, and goslings. This comprehensive study enhances researchers’ understanding of the transmission characteristics and virulence of GAstV genotype-2, aiding in a better comprehension of their molecular epidemiology and pathogenic mechanism.
Multi-domain feature joint optimization based on multi-view learning for improving the EEG decoding
Authors: Shi Bin , Yue Zan , Yin Shuai , Zhao Junyang , Wang Jing
Published: December 2023

Background

Brain-computer interface (BCI) systems based on motor imagery (MI) have been widely used in neurorehabilitation. Feature extraction applied by the common spatial pattern (CSP) is very popular in MI classification. The effectiveness of CSP is highly affected by the frequency band and time window of electroencephalogram (EEG) segments and channels selected.

Objective

In this study, the multi-domain feature joint optimization (MDFJO) based on the multi-view learning method is proposed, which aims to select the discriminative features enhancing the classification performance.

Method

The channel patterns are divided using the Fisher discriminant criterion (FDC). Furthermore, the raw EEG is intercepted for multiple sub-bands and time interval signals. The high-dimensional features are constructed by extracting features from CSP on each EEG segment. Specifically, the multi-view learning method is used to select the optimal features, and the proposed feature sparsification strategy on the time level is proposed to further refine the optimal features.

Results

Two public EEG datasets are employed to validate the proposed MDFJO method. The average classification accuracy of the MDFJO in Data 1 and Data 2 is 88.29 and 87.21%, respectively. The classification result of MDFJO was significantly better than MSO (p < 0.05), FBCSP32 (p < 0.01), and other competing methods (p < 0.001).

Conclusion

Compared with the CSP, sparse filter band common spatial pattern (SFBCSP), and filter bank common spatial pattern (FBCSP) methods with channel numbers 16, 32 and all channels as well as MSO, the MDFJO significantly improves the test accuracy. The feature sparsification strategy proposed in this article can effectively enhance classification accuracy. The proposed method could improve the practicability and effectiveness of the BCI system.
Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis
Authors: Latchney Sarah E. , Ruiz Lopez Brayan R. , Womble Paige D. , Blandin Katherine J. , Lugo Joaquin N.
Published: December 2023

Adult neurogenesis is a persistent phenomenon in mammals that occurs in select brain structures in both healthy and diseased brains. The tumor suppressor gene, phosphatase and tensin homolog deleted on chromosome 10 (Pten) has previously been found to restrict the proliferation of neural stem/progenitor cells (NSPCs) in vivo. In this study, we aimed to provide a comprehensive picture of how conditional deletion of Pten may regulate the genesis of adult NSPCs in the dentate gyrus of the hippocampus and the subventricular zone bordering the lateral ventricles. Using conventional markers and stereology, we quantified multiple stages of neurogenesis, including proliferating cells, immature neurons (neuroblasts), and apoptotic cells in several regions of the dentate gyrus, including the subgranular zone (SGZ), outer granule cell layer (oGCL), molecular layer, and hilus at 4 and 10 weeks of age. Our data demonstrate that conditional deletion of Pten in mice produces successive increases in dentate gyrus proliferating cells and immature neuroblasts, which confirms the known negative roles Pten has on cell proliferation and maturation. Specifically, we observe a significant increase in Ki67+ proliferating cells in the neurogenic SGZ at 4 weeks of age, but not 10 weeks of age. We also observe a delayed increase in neuroblasts at 10 weeks of age. However, our study expands on previous work by providing temporal, subregional, and neurogenesis-stage resolution. Specifically, we found that Pten deletion initially increases cell proliferation in the neurogenic SGZ, but this increase spreads to non-neurogenic dentate gyrus areas, including the hilus, oGCL, and molecular layer, as mice age. We also observed region-specific increases in apoptotic cells in the dentate gyrus hilar region that paralleled the regional increases in Ki67+ cells. Our work is accordant with the literature showing that Pten serves as a negative regulator of dentate gyrus neurogenesis but adds temporal and spatial components to the existing knowledge.