bluuebunny/crossref_metadata_2025 huggingface dataset:
Air refiner breather/disinfection unit (water seal system) is a clinically useful and cost-effective device for COVID-19 patients
Authors: Faruquzzaman -
Published: October 2022

Coronavirus disease-2019 (COVID- 19) pandemic declared by the World Health Organization (WHO) on 11th March 2020, caused by the SARS-CoV-2 virus is at an exponentially rising state across the globe. Bangladesh is also facing the toll of this highly transmissible zoonotic disease with community transmission (at a different rate) across the country. This is a new coronavirus, still evolving, and has put the scientific authority in a puzzle. Prevention of transmission and contamination (especially via air-borne route) is the main aim here. Moreover, prevention of contamination of Intensive care unit (ICU) and operation theater (OT) equipment and environment is an optimal target. Gas and smoke evacuation during laparoscopy and pneumoperitoneum is also a big question. Cost-effectiveness is another important aspect. Different processes, techniques, devices, etc. have been tried so far. Here, a new device is going to be reported in this paper in such relation.
Mediscope 2022;9(2): 81-84
Antibody level against COVID-19 among the vaccinated infected and non-infected doctors by SARS-COV-2: A Comparative study
Authors: Akhter Nazma , Mollah Forhadul Hoque , Jahan Nowrose , Adam Jurdi , Hossain Md Arif , Chowdhury Md Zaforullah
Published: October 2022

Introduction: A novel coronavirus (2019-nCoV or SARS-CoV-2) emerged at the end of 2019 in Wuhan, Hubei province, China named as COVID-19. IgM, the first antibody produced by the body, is generated gradually 1 week after symptom onset and declines by 4 weeks after the COVID infection. In this background, the antibody response was observed in vaccinated (by Oxford-AstraZeneca) doctors of SSMC(Sir Salimullah Medical College) with or without previous COVID-19 infection. Methodology: This cross-sectional analytical study was conducted in the Department of Biochemistry and Molecular Biology at SSMC and BSMMU. A total of 70 doctors of SSMC aged 25-59 years were enrolled according to inclusion criteria. Among them 35 vaccinated doctors were previously infected by SARS-CoV-2 regarded as group A and another vaccinated 35 doctors were non-infected regarded as group B. Collected data was analyzed by Statistical Package for Social Science 26 (SPSS 26). The data were expressed as frequency and percentage, mean ± SD for normally distributed data or median (inter-quartile rage) for data not normally distributed. Mann-Whitney test was done to compare IgG status between vaccinated SARS-CoV-2 infected and non-infected individuals. Result: There was significantly higher level of antibodies (serum IgG level) present in fully vaccinated doctors with previous SARS-CoV-2 infection than in only vaccinated doctors without prior infection.
Update Dent. Coll. j: 2022; 12(2): 19-23
Gorlin Goltz Syndrome- A Rare Disease Reported In Bangladesh
Authors: Afroze Nafisa , Islam ASM Ariful , Islam Md Shofiqul , Lipi Jeyasmin Akter
Published: October 2022

Gorlin-Goltz syndrome is an infrequent multisystemic disease with an autosomal dominant trait with complete penetrance and various expressivity. Gorlin Goltz Syndrome is a rare autosomal characterized by an increased predisposition to basal cell carcinoma and associated with multiorgan anomalies having a high level of penetrance. We report here a 60-year-old patient with positive findings of Gorlin-Goltz Syndrome.The following report emphasizes the identification of all the essential clinical diagnostic criteria ,radiological manifestations, and possible genetic tests to be performed for setting up an adequate treatment plan.
Update Dent. Coll. j: 2022; 12(2): 32-36
Think, Check & Submit: Unique Approach to Journal Selection
Authors: Iqbal Md Ashif
Published: October 2022

In recent decades, the fast transition from print to digital publishing has resulted in an unparalleled increase in scholarly journal publications. The wide range of options accessible to them is increasingly overwhelming to many academics, particularly early-career scholars, researchers, or faculty members of an institution online. Researchers questioned following their findings, "Where should I publish my article for others to read?" In science, the answer to this issue has never been trivial, but it is today more crucial than ever.
How can you, as a researcher, determine whether the publication you are going to submit your research to is legitimate? Think. Check. Submit, a campaign by a consortium of scholarly communications groups, may hold the key to finding the solution. Think, Check, and Submit is a tool that facilitates the process of selecting the best journal for your research publication. It is getting harder and harder to choose which academic publication is worthy of your work with the release of hundreds of new academic online journals every year. Although having more options is typically a good thing, the profusion of new titles has also led to a rise in what some refer to as "predatory publishing."
Update Dent. Coll. j: 2022; 12(2): 1-2
La Iglesia de Atlántida de Eladio Dieste refuerza la presencia de la arquitectura moderna en la Lista del Patrimonio Mundial
Authors: Pérez Escolano Víctor
Published: October 2022

“Constituye un ejemplo eminente de los notables logros formales y espaciales de la arquitectura moderna en América Latina durante la segunda mitad del siglo XX y encarna la búsqueda de la igualdad social con un sobrio uso de los recursos, cumpliendo los imperativos estructurales con un gran efecto”. De esta forma, en julio de 2021, justificaba la Unesco la designación de la Iglesia de Atlántida del ingeniero uruguayo Eladio Dieste como Patrimonio Mundial. En esta 44ª reunión del Comité del Patrimonio Mundial, la última celebrada hasta la fecha, casi una decena de elementos contemporáneos ingresaban en la Lista del Patrimonio Mundial, prueba fehaciente de cómo se ha avanzado en el reconocimiento y la protección a los bienes culturales producidos en nuestra época.
La Convención del Patrimonio Mundial, cincuenta años después de su aprobación
Authors: Conti Alfredo
Published: October 2022

La conmemoración del cincuentenario de la Convención del Patrimonio Mundial, adoptada por la Conferencia General de la UNESCO el 16 de noviembre de 1972, se da en un momento en que la humanidad se enfrenta a situaciones complejas, tales como los impactos del cambio climático, la inesperada pandemia COVID-19, que puso en evidencia desigualdades aun en el interior de algunos países, y una serie de conflictos bélicos y humanitarios, de los cuales el más reciente es la invasión por parte de la Federación Rusa al territorio soberano de la República de Ucrania. Puede resultar difícil, por lo tanto, proceder a una evaluación del significado y alcances de la Convención sin abstraerse del contexto y de la pregunta acerca de si los ideales propuestos para la UNESCO en su fundación en 1945 han podido realmente concretarse.

Un recorrido exhaustivo por el medio siglo de la Convención excedería ampliamente los límites de un artículo. Se procede, por lo tanto, a mencionar solo algunos momentos o aspectos que se han considerado significativos para narrar y analizar el devenir del sistema Patrimonio Mundial, de modo de extraer algunas conclusiones que permitan un somero balance de lo logrado y de los desafíos que se esperan en el futuro próximo. El sistema creado por la Convención ha permitido, sin dudas, poner en evidencia sitios importantes para toda la humanidad y contribuir a su adecuada gestión. Pero, por otra parte, pone en evidencia desigualdades y diferencias de oportunidades entre regiones y países del mundo.
Cosano Moyano, J. y Escobar Camacho, J.M. (coord.) (2020) Córdoba, póker de P4trimonios de la Humanidad
Authors: López Méndez Lorena
Published: October 2022

Resumen del libro, coordinado por Cosano Moyano, J. y Escobar Camacho, J.M. Córdoba, póker de P4trimonios de la Humanidad. sl: Fundación Pro Real Academia de Córdoba, 2020
El concurso Becatalaiotica difunde la candidatura Menorca Talayótica como Patrimonio Mundial entre el público joven
Authors: De Salort Giménez Carlos , Melià Sintes Maria Eva
Published: October 2022

Becatalaiotica es un proyecto cultural original de la asociación de Amics del Museu de Menorca con el espíritu de dar visibilidad al talento joven, reivindicar el valor inspirador del paisaje y promover la candidatura de Menorca Talayótica a Patrimonio Mundial entre nuevos públicos. Estudiantes de entre 18 y 28 crean eventos de carácter libre en diferentes espacios de la candidatura. Cualquier campo del conocimiento y método de expresión es válido. Se buscan propuestas críticas, de ensayo, performativas o de cualquier otra naturaleza mientras otorgue su justo lugar al conocimiento científico. El público de los eventos es el encargado de evaluar la originalidad, el contenido y la capacidad de sugestión de las propuestas. La mejor valorada gana una beca de estudios de 2000€.
Antecedentes y primeros pasos ante la ratificación de España en 1982 de la Convención del Patrimonio Mundial
Authors: Tresserras Juan Jordi
Published: October 2022

Con motivo de este quincuagésimo aniversario de la Convención de Patrimonio Mundial, se ha considerado importante realizar una mirada retrospectiva de cómo España empleó la diplomacia cultural para crear redes y alianzas de cooperación tras el bloqueo internacional a la dictadura de Franco. Proceso que siguió tras el periodo denominado de la Transición y el restablecimiento democrático en el cual se realizan los primeros pasos para su ratificación e implementación, con instrumentos necesarios como un nuevo marco legal (la Ley 16/1985 del Patrimonio Histórico Español) y el procedimiento de candidaturas que España presentaría para incorporación a la Lista del Patrimonio Mundial. En esta primera, la lista fase estuvo engrosada por los primeros cincos bienes en inscribirse: la Alhambra de Granada y el Generalife, la Catedral de Burgos, la Mezquita de Córdoba, el Monasterio y Sitio de San Lorenzo de El Escorial y las obras de Antoni Gaudí (el Palau Güell, el Park Güell y la Casa Milà-La Pedrera). Se incluyeron también la Cueva de Altamira, el Acueducto de Segovia, el Conjunto Arquitectónico Prerrománico Asturiano, la Catedral de León, el Museo del Prado y Santo Domingo de Silos, así como el Conjunto Monumental de Santiago de Compostela, la Catedral de Jaén y las Murallas de Ávila.
Treatment management of patients with systemic lupus erythematosus: a delphi consensus analysis
Authors: Sebastiani Gian Domenico , Mosca Marta , Ravasio Roberto , Brambilla Pietro , Raimondo Paola , Doria Andrea
Published: October 2022

Background: Systemic lupus erythematosus (SLE) is associated with clinical burden for the patient and organ damage. The development of therapies for SLE has been constrained by clinical and biologic heterogeneity. These represent challenges in clinical trial design and endpoint selection.
Objective: To identify the most relevant descriptors for efficacy, endpoints, disease activity, organ damage, quality of life (QoL), and Patient Reported Outcome Measures (PROMs) in the treatment of SLE.
Methods: A Delphi study was conducted using a national expert panel of clinicians in the treatment of SLE. A steering committee composed of 3 opinion leaders with deep expertise in SLE treatment was defined. The steering committee analyzed and appraised the evidence, designed the Delphi study, defined the statements, and analyzed the expert panel responses. A 2-round Delphi survey was conducted. Participants were asked to rate the statements using a five-point Likert scale.
Results: Nine experts participated in the Delphi survey. After the two rounds, the consensus was reached on 18 of the 23 statements: 2 statements were included in the “efficacy” domain, 2 in the “glucocorticoid-sparing” domain, 2 in the “endpoint evaluation” domain, 4 in the “score” domain, 1 in the “disease activity” domain, 1 in the “organ damage” domain, 1 in the “QoL” domain, 2 in the “PROMs” domain, 1 in the “AIFA monitoring” domain and 2 in the “extra” domain. No statements reached consensus within the “onset” domain.
Conclusion: In this Delphi study, 18 statements across 11 domains were agreed upon for the treatment of SLE.
Effect of Classic or Delayed Ischemic Conditioning on Left Ventricular Pressure-Volume Relations in Dogs
Authors: J.G. Jr Kingma , D Simard , J.R Rouleau
Published: October 2022

Objective: Non-pharmacologic interventions such as ischemic conditioning (IC) markedly reduce infarct size but it remains unclear whether this protection translates to a significant attenuation of ischemia-mediated LV contractile dysfunction. In this study we evaluated pressure-volume (P-V) data obtained by the load-insensitive conductance catheter method, to examine LV pressure-volume (LVP-V), diastolic function and ventricular-arterial coupling in anesthetized dogs exposed to ischemic conditioning (IC) or delayed IC (dIC; 48h prior to ischemia). The objective was to determine if IC, or dIC pre-treatment could influence post-ischemic recovery of LV contractile function. Methods: Three groups were studied – nIC, IC and dIC; all dogs underwent 90-min acute coronary occlusion (CO) followed by 180-min reperfusion (REP). IC consisted of 4 cycles of 5-min CO and 5-min REP of the left main coronary artery. LV P-V relations were constructed under steady-state conditions (by transient occlusion of the inferior vena cava) prior to IC treatment and at the end of the experiment; P-V loop data was also acquired at different points during the experiment to evaluate changes in end-systolic and end-diastolic parameters. Results: During CO dP/dtmax and dP/dtmin (indicator of rate of LV relaxation) decreased significantly compared to baseline in the IC group; these variables were unchanged in the dIC group. LVEF decreased during CO and REP in the nIC and IC groups but was stable in the dIC group. Tau was increased only in the IC group during CO and REP. ESV and EDV increased significantly in all groups during CO and REP; none of these negative effects was resorbed by the end of the experimental period. Conclusions: Diminished LV contractile function caused by CO did not improve with IC, or dIC pre-treatment, despite significant reduction in infarct size.
Comparison of the Renal Function Using Two Different Approaches for Primary Percutaneous Coronary Intervention: A Retrospective Cohort Study
Authors: Gwefel Ahmed , Louis Osama , Yassin Ihab
Published: October 2022

Background: Contrast-induced nephropathy (CIN) continues to be one of the most common major adverse side effects of cardiac catheterization, and is associated with short- and long-term morbidity and mortality. Since the trans-radial approach to coronary angiography was first reported in 1989, trans-radial access has been used for primary percutaneous coronary intervention (PCI) for approximately 20 years. There is a growing perception that, within the setting of intra-arterial procedures, there is a different risk factor for renal involvement when using radial or femoral access, with femoral access leading to the greatest risk because of its proximity to the high flow bed of the renal arteries. This study aimed to compare the degree of renal dysfunction by different indices in trans-radial and trans-femoral primary PCI. Materials and Methods: This study had been conducted in the cardiology department; the National Heart Institute during the period from September 2018 to February 2020. The study included 90 patients admitted to the hospital with acute myocardial infarction and underwent primary PCI either through a femoral or radial with the Cystatin C and serum creatinine measured before and 72 hours of primary PCI. Results: A statistical difference between both groups regarding CIN, with p-value=0.044 was found. There was no statistical difference between both groups after PCI regarding serum creatinine and cystatin C with p-value: 0.723 and 0.439, respectively. Concerning serum urea, there was statistical difference between both groups after PCI in the direction to be more in the radial group: it was 28.46 ± 13.89 mg/dl in femoral group and 30.06 ± 7.99 mg/dl in radial group (p=0.003). However, time to vascular access was easier with femoral group than with radial group with p-value < 0.001. Regarding complications, there were no statistical difference between two groups except for hematoma (p-value=0.026) Conclusion: The study showed significant results according to developing CIN between the two groups which is more in femoral approach. The study showed that serum cystatin C didn’t add value to diagnosis of CIN.
Factors Associated with the Refusal of Vaccination Against COVID-19 Among Students of The Faculty of Health Sciences of Congo
Authors: clauvel Niama Ange , Valérie Yolande Mavoungou Yvonne , Ndziessi Gilbert , Ikoungou Kévine , Ngamille Chéripin , Bayonne Sophie
Published: October 2022

Background: COVID-19 is responsible for high morbidity and mortality. Vaccination is the main response strategy. Vaccination coverage remains low. This study investigated the factors for refusal of COVID-19 vaccination among health sciences students. Methodology: This was an analytical cross-sectional study conducted from July to October 2021. The cluster method was used and the Schwartz formula was used to obtain the minimum sample size. Socio-demographic, socio-cultural and vaccination status variables were collected. Statistical analysis was performed with Epi Info 7.2.2.6 software. The significance level was set at 5% Results: A total of 423 students were included. Vaccination coverage was 12.77%. The rate of students refractory to vaccination was 45.62%. Females were in the majority (54.40% vs 54.60%). The factors associated with refusal of the COVID-19 vaccination in our study were: lack of knowledge of the vaccines available in Congo (ORa=1.601 [1.009-2.539]; p=0.0453), perception of the uselessness of the vaccine (ORa=6.055 [3.646-10.055]; p < 0.0001) and the unavailability of the vaccine the student wishes to receive (ORa=2.652 [1.365-5.152]; p = 0.004). Conclusion: This study reveals low vaccination coverage and almost half of the students were refractory to vaccination against COVID-19. Awareness and involvement of students in health sciences who are public health actors are necessary to improve this vaccination coverage.
Humanização nas unidades de terapia intensiva participação do enfermeiro
Authors: Bomfim Vitoria Vilas Boas da Silva , Rubin Onilda , Milhomem Nayara Lima , Souza Lívia Barbosa Pacheco , Sousa Thalita Bragato , Pedro Isis Silva de São , Volpp Ana Flávia Espíndola
Published: October 2022

O cuidado humanizado de enfermagem na UTI só ocorrerá se estiver envolvimento existencial dos cuidadores com o ser doente e familiar, onde se vivencia e compartilha a experiência, possibilitando um cuidado que rompa com o modelo assistencial predominante, cujo objetivo maior é a cura. O presente estudo tem como objetivo descrever o papel do enfermeiro no âmbito da humanização nas UTI’s. Trata-se de um estudo do tipo exploratório descritivo e abordagem qualitativa, o critério de inclusão utilizado no estudo foi realizado com base em artigos científicos voltados para o tema abordado, a coleta de dados será feita a partir da utilização das palavras chaves utilizado a técnica de análise de conteúdo proposta por Bardin. A partir do levantamento teórico realizado nesse trabalho foi possível compreender, dentro das diversas abordagens apresentadas acerca do assunto, a relevância da participação do enfermeiro quando se pretende humanizar Unidades de Terapia Intensiva (UTIs). Por todos esses fatores apresentados ao longo do estudo, é válido informar que faz- se necessário cada vez mais aprofundar estudos nesta área, envolvendo a equipe multidisciplinar e deixando claros os princípios, métodos e diretrizes a serem seguidos no sentido de buscar uma prática mais humanizada.
Parada cardiorrespiratória: cuidados pós retorno da circulação espontânea
Authors: Santos Jéssica Batista dos , Costa Christefany Régia Braz
Published: October 2022

O referido trabalho tem como foco discutir os cuidados pós retorno da circulação espontânea utilizados em paciente com Parada Cardiorrespiratória. O objeto do artigo: Analisar quais são os procedimentos a serem aplicados no atendimento de um paciente com quadro de parada cardiorrespiratória; Investigar quais os cuidados a serem aplicados a um paciente com quadro de pós retorno da circulação espontânea. A metodologia utilizada para embasar o trabalho foi a revisão narrativa. Conclusão: os procedimentos a serem aplicados no atendimento de um paciente com quadro de PCR envolvem Suporte Básico de Vida (SBV) e o Suporte Avançado de Vida (SAV). Já os cuidados a serem tomados durante o atendimento de um paciente de pós retorno da circulação espontânea em consequência de uma PCR, além dos SBV e SAV, são: os estágios de atenção imediata ou precoce, recuperação e reabilitação e a realização de avaliações físicas, neurofisiológica, cognitivas e psicossociais, para detectar sequelas. Também é recomendado a realização de exames como Tomografia Craniana, Ressonância Magnética e uma Espectroscopia de ressonância magnética e tomografia de emissão de pósitrons (PET), para verificar a existência de lesões cerebrais. Além disso, são recomendados outros cuidados como, suportes ventilatórios, hemodinâmicos, neurológico e metabólico otimizados e Hipotermia Terapêutica (HT).
Um desafiante diagnóstico diferencial para Síndrome Pelizaeus-Merzbacher: uma revisão da literatura
Authors: Borges Ericks Domiciano , Alves Nathan Colombo , Torrieri Érico , Froio Karen Cristina , Pereira Priscilla Aparecida Tartari
Published: October 2022

Em crianças, as doenças da substância branca são divididas tradicionalmente em duas principais categorias: leucodistrofia e leucoencefalopatias. Sendo as primeiras, o resultado da deficiência enzimática hereditária que causa uma formação anormal, renovação da mielina ou destruição. Em contrapartida, as leucoencefalopatias envolvem a destruição da mielina intrinsecamente normal, tendo como mecanismo da desmielinização a divisão primariamente em lisossomal, e peroxissomal.  Neste contexto, a Síndrome Pelizaeus-Merzbacher (PMD) é uma leucodistrofia ligada ao cromossomo X, caracterizada pelo atraso no desenvolvimento neuropsicomotor em crianças. Trata-se de uma doença rara, com predominância para sexo masculino comprometendo o desenvolvimento e/ou a manutenção da mielina no Sistema Nervoso Central (SNC). Logo, o presente estudo objetivou reunir artigos científicos através de uma revisão narrativa sobre a Doença Pelizaeus Merzbacher abordando sua classificação, fisiopatologia, sinais e sintomas e os desafios para se chegar em seu diagnóstico. Desta forma, este estudo traz novas atualizações sobre a doença e auxílio no direcionamento para um diagnóstico diferencial, assim como, buscar uma melhor intervenção para pacientes com Síndrome Pelizaeus-Merzbacher.
Manejo odontológico de paciente portador de epilepsia: uma revisão de literatura
Authors: Rodrigues Aline dos Santos , Oliveira Raissa Teixeira de , Rocha Angélica Pereira
Published: October 2022

A epilepsia é o distúrbio neurológico de maior incidência, sendo o mais comum, não apresentando características orais e odontológicas específicas. Foi realizada uma revisão de literatura, utilizando artigos de bases de dados indexadas, entre os anos de 2009 e 2022. É necessário que o cirurgião-dentista esteja capacitado para propor atendimento a pacientes portadores de epilepsia, pois, embora o manejo odontológico não tenha tantas particularidades, algumas precisam ser bem estabelecidas: o uso correto de anestésicos, o posicionamento correto na cadeira, ação correta caso o paciente tenha uma crise convulsiva durante o atendimento, o correto manejo dos tecidos periodontais caso os mesmos estejam hiperplasiados em decorrência do uso de anticonvulsivantes e a indicação correta dos tratamentos, portanto, conclui-se que o cirurgião-dentista deve estar capacitado para atender tais pacientes e saber os cuidados e abordagens necessárias em caso de crises durante o atendimento odontológico.
Diferentes relações entre hipertensão e insônia: uma revisão integrativa
Authors: Toledo Samuel Lopes , Andrade João Pedro Gontijo , Almeida Breno Casellatto Rodrigues , Giffoni Barbosa Natalia , Barbosa Leonardo Roberto , Silva Tourinho Fillipe , Silva Gabriel Vinícius Rodrigues da , Bologna Giovanni Tessarine Barbosa , Duarte Gema Galgani de Mesquita , Soares Evelise Aline
Published: October 2022

Introdução: A insônia e os distúrbios de sono são condições que causam danos notáveis aos indivíduos. Tais danos incluem, possivelmente, um aumento da pressão arterial média, o que pode acarretar Hipertensão Arterial Sistêmica (HAS). O objetivo desta revisão é identificar como algumas variáveis qualitativas e quantitativas do sono podem alterar a pressão arterial, sobretudo, de pessoas com insônia. Metodologia: Trata-se de uma revisão integrativa de literatura, que inclui estudos com diferentes grupos populacionais ao longo do tempo. As bases de dados utilizadas para a coleta dos artigos foram PubMed, MEDLINE e LILACS, sendo que apenas trabalhos publicados entre 2002 e 2022 foram considerados. Resultados: 12 artigos analisados (75%) corroboram a influência da insônia sobre a pressão arterial. Nesse sentido, o sono curto, a irregularidade do sono, a dificuldade de iniciar e manter o sono, a baixa proporção do sono REM em relação ao sono NREM e alterações do sistema nervoso autônomo no ciclo sono-vigília são fatores associados à insônia que se mostraram como potenciais promotores da HAS. Conclusão: Embora outras variáveis fisiológicas e sociais impactem sobre a pressão arterial, é necessário, também, observar a influência do sono sobre a HAS. Isso porque, da totalidade dos artigos incluídos nesta revisão, apenas 25% não garantem haver associação entre insônia e hipertensão. A partir desses dados, é notável que aspectos quantitativos e qualitativos do sono devem ser foco de medidas de controle da hipertensão, doença crônica que se apresenta como fator de risco para uma série de distúrbios e eventos cardiovasculares.
Inspeção da qualidade do pescado fresco na principal feira da Capital Amazonense, Manaus-AM
Authors: Correa Djeyla da Silva , Silva Naytê Figueredo da , Ale Vanessa Maria Machado
Published: October 2022

O pescado é um alimento que traz benefícios à saúde, pois contém alto valor nutricional e sua presença no organismo possibilita o fortalecimento do sistema imunológico. O seu frescor e qualidade tornam-se importantes para garantir a segurança do produto para o consumidor. É um alimento de fácil decomposição e os cuidados em sua captura, transporte, manipulação e armazenamento devem ser redobrados. Diante disso, a presente pesquisa tem como objetivo analisar a qualidade do pescado fresco e coletar dados relacionados às condições higiênicas gerais da principal feira da Capital Amazonense. Foram feitas análises das conformidades e não conformidades de 5 peixes de diferentes peixarias da feira, onde os dados obtidos na análise sensorial da qualidade do pescado fresco foram 53% de itens não conformes e 47% de itens conformes. De acordo com os resultados, o presente estudo buscou mostrar a importância da fiscalização das feiras para que sejam cumpridas as diretrizes da higiene e segurança do alimento, pois as Boas Práticas de Higiene e Segurança garantem o controle de qualidade do produto e evitam os riscos de contaminação do alimento, ajudando assim na diminuição da proliferação de doenças causadas pela ingestão de alimentos contaminados.
Abraço atencioso: uma experiência de comunicação durante a pandemia de COVID-19
Authors: Dias Bruna , Sousa Márcia de , Fusco Suzimar de Fátima Benato , Pedrosa Rafaela Batista dos Santos
Published: October 2022

A presença de um familiar contribui para a segurança do cuidado, mantém o vínculo familiar e desempenha um papel vital nos resultados de saúde. Como precaução à transmissão da COVID-19, a possibilidade de ter um familiar na unidade de terapia intensiva (UTI) foi suspensa e a comunicação entre o paciente e sua família foi interrompida. Este estudo teve como objetivo apresentar a experiência da equipe com uma intervenção de enfermagem intitulada “Abraço Virtual”, implementada em uma UTI de um hospital público brasileiro. Foi disponibilizada uma sala onde a família poderia escrever cartas de próprio punho, depositá-las em uma caixa e, em seguida, serem lidas em voz alta para o paciente pelos profissionais de saúde. Esta intervenção com foco na comunicação proporcionou um cuidado integral e humanizado, tornando-se uma ferramenta de apoio emocional. Reduziu o impacto produzido pela ruptura no vínculo afetivo pela necessidade de isolamento, corroborando com as políticas públicas de humanização e enfermagem de família.
Prevalence and genotype of Toxoplasma gondii in stranded Hawaiian cetaceans
Authors: Landrau-Giovannetti N , Waltzek TB , López-Orozco N , Su C , Rotstein D , Levine G , Rodrigues TCS , Silva-Krott I , Humann C , West K
Published: October 2022

Toxoplasma gondii is a significant threat to endangered Hawaiian wildlife including birds and marine mammals. To estimate the prevalence of T. gondii in stranded cetaceans from 1997 to 2021 in Hawai‘i, we tested tissues from 37 stranded spinner dolphins Stenella longirostris and 51 stranded individuals that represented 18 other cetacean species. DNA from cetacean tissue extracts were screened using a nested polymerase chain reaction (PCR) assay targeting the Toxoplasmatinae internal transcribed spacer 1 of the nuclear ribosomal DNA. A positive result was obtained in 9 tissues examined for each of 2 spinner dolphins out of 525 tissue samples analyzed by PCR. The PCR-positive spinner dolphins had disseminated acute toxoplasmosis with necrosis, inflammation, and intralesional protozoal cysts and tachyzoites in multiple organs. Discrete positive immunostaining for T. gondii was observed in all tissues tested including the adrenal gland, brain, liver, and lung. Both positive spinner dolphins were negative for cetacean morbillivirus. The T. gondii genotyping was performed by restriction fragment length polymorphism (PCR-RFLP) based on 10 genetic markers. The PCR-RFLP analysis revealed the T. gondii belonged to PCR-RFLP-ToxoDB genotype #24, previously detected in wild pig Sus scrofa in O‘ahu, bobcats Lynx rufus from Mississippi, USA, and chickens Gallus gallus from Costa Rica and Brazil. These cases represent the first report of this genotype in aquatic mammals and the second and third reports of fatal disseminated T. gondii infection in stranded spinner dolphins from Hawai‘i. Nearshore species, like spinner dolphins, may be at increased risk of mortality from this parasite in marine coastal waterways via sewage systems, storm water drainage, and freshwater runoff.
Temporal dynamics of a Sabellaria wilsoni (Sabellariidae: Polychaeta) reef on the Brazilian Amazon Coast
Authors: Aviz D , Rollnic M , Nascimento IBA , Pinheiro LA , Rosa Filho JS
Published: October 2022

Polychaetes of the family Sabellariidae build extensive reefs in many coastal regions worldwide. These structures are dynamic systems that undergo a natural cycle of growth and destruction provoked by fluctuations in hydrodynamic conditions and biological factors. Here, we monitored a Sabellaria wilsoni reef over an annual cycle on Algodoal-Maiandeua Island on the Brazilian Amazon coast. We studied the impact of temporal variations in local environmental characteristics on the structure of the reef and the reef-building polychaete population. Metrics included the local climate (temperature, rainfall, and winds), hydrological variables (suspended particulate matter and salinity), and the output of a numerical model of the local hydrodynamics. There was increased hydrodynamic stress in the dry season due to changes in the direction and intensity of the wind and stronger waves. This in turn led to an accentuated decrease in sabellariid density, and the eventual erosion of the reef, which lost >80% of its original area. The reduction in the hydrodynamic energy at the end of the rainy season favoured the mass recruitment of sabellariids as well as the subsequent growth and recuperation of the reef. Oligohaline conditions also contributed to a reduction in worm density, but not to any loss in reef structure. These findings provide important insights into the thresholds of energy and salinity tolerated by the reef-building polychaete S. wilsoni and offer a useful baseline for future research on the ecology of this species and the monitoring of this important marine habitat.
A reciprok tanítási módszer elemeinek jelentősége az olvasás–szövegértés tanítás eredményességének fejlesztésében
Authors: Huszár-Samu Nóra , Steklács János
Published: October 2022

Az olvasási, szövegértési képesség jelentősége nagymértékben átértékelődött az elmúlt évtizedekben, ezeknek a képességeknek a megfelelő szintje minden további tanulás előfeltétele, ezzel együtt általánosságban a boldogulás fontos tényezője az egyén életében az információs társadalomban egyaránt (Grabe–Stoller 2011; Schnotz–Molnár 2012). Bár az olvasás, szövegértés megfelelő szintjének elérése társadalmi igény, napjainkban ennek ellenére a literacy crisis, az olvasás válsága és funkcióvesztése a jellemző (Szenczi 2010; Józsa–Józsa 2014).  Az iskolának mint intézménynek reflektálnia kell a társadalom szükségleteire, de a szövegértés képességét azért nem tudja mindennapi társadalmi igényeknek és elvárásoknak megfelelően kialakítani kisiskolás korban, mert a nemzetközi kutatások a szövegértésről alkotott új tudáskoncepció és a módszertani eszköztár és kultúra fejlődése számottevő különbségeket mutat. A szövegfeldolgozás módszertanának jelentős tartalékai maradnak kiaknázatlanul az elmélet és gyakorlat eltéréseinek okán. Tanulmányunkban arra kívánunk rámutatni, hogy az alsó tagozaton történő olvasásmegértés hatékony és gyakorlatorientált fejlesztése a metakognitív folyamatok és struktúrák fejlesztésében rejlik. Az olvasástanítás dekódolási, automatizálási szakasza utáni, a szövegértés tanítását explicit módon célzó szakasza, egyben egyik leghatékonyabb módszere az olvasási stratégiákra épül. Ez az egyik elméleti alapvetése a reciprok módszernek is, melynek elemei a gyakorlatban a tanórába illeszthetőek, és lefedik a metakognícióról alkotott elméleti keretet.
PENINGKATAN PRODUKTIVITAS USAHA MELALUI KEGIATAN PENDAMPINGAN SOSIAL SEBAGAI RANGKAIAN PROGRAM KEWIRAUSAHAAN SOSIAL PADA KECAMATAN SUSUKAN KABUPATEN SEMARANG
Authors: Eva Purnamasari  , Ayuwardani Mellasanti
Published: October 2022

This social mentoring activity is a part of the Social Entrepreneurship Program, a collaboration between the Semarang State Polytechnic and the Ministry of Social Affairs, especially the Directorate of Individual, Family and Institutional Social Empowerment. The activity involves lecturers and students, as well as coordinators and assistants from the ministry. Susukan District is one of the areas that is a priority assistance area in Semarang Regency. The target of the program is the Beneficiary Families (KPM), and aims to provide business assistance for KPMs so that they are able to develop their ultra-micro businesses. With this assistance, the ultra-micro business of the KPM business can develop both in terms of model, capital, assets and business turnover through mentoring in production, packaging, marketing, and also legal aspect.

 

Kegiatan pendampingan sosial ini merupakan rangkaian dari Program Kewirausahaan Sosial, kerjasama Politeknik Negeri Semarang dengan Kementerian Sosial khususnya Direktorat Pemberdayaan Sosial Perorangan, Keluarga dan Kelembagaan Masyarakat. Kegiatan melibatkan dosen dan mahasiswa, serta koordinator serta pendamping dari pihak kementerian. Kecamatan Susukan merupakan salah satu wilayah yang menjadi area pendampingan prioritas pada Kabupaten Semarang. Sasaran program adalah para Keluarga Penerima Manfaat (KPM), dan  bertujuan untuk memberikan pendampingan usaha bagi KPM agar mereka mampu mengembangkan usaha ultra mikro yang mereka miliki. Dengan pendampingan ini usaha ultra mikro usaha KPM dapat berkembang baik secara model, modal, aset dan omset usaha melalui pendampingan sosial di bidang produksi, kemasan, pemasaran dan aspek legalitas.
Analisis Faktor-Faktor Kesiapan Kerja di Bidang Kuliner pada Siswa Sekolah Menengah Kejuruan
Authors: Melinia Nadia , Mariah Siti
Published: October 2022

This study aims to determine the factors of job readiness in the culinary field. This research is a quantitative research. Data collection techniques used questionnaires and documentation. The validity of the items was tested with the product moment correlation, the results obtained were 19 valid items and 3 items failed. The results of the reliability test obtained the value of Alpha = 0.951. Data analysis techniques in this study are the mean, median, mode, and standard deviation. The results showed that the factors of job readiness in the culinary field in Vocational High School students were in the sufficient category with a relative frequency of 60.32%. The variables of job readiness factors in the culinary field have two indicators, namely internal factors and external factors. (1) Internal factors are in sufficient category with a relative frequency of 66.67% and (2) external factors are in sufficient category with a relative frequency of 52.38%. It can be concluded that the internal and external factors of work readiness in the culinary field are quite sufficient. Students are expected to be more active and confident in learning theory and practice.
Advanced nanoparticles that can target therapy and reverse drug resistance may be the dawn of leukemia treatment: A bibliometrics study
Authors: Wang Rui , Zhao Changming , Jiang Shuxia , Zhang Zhaohua , Ban Chunmei , Zheng Guiping , Hou Yan , Jin Bingjin , Shi Yannan , Wu Xin , Zhao Qiangqiang
Published: October 2022

With the development of nanomedicine, more and more nanoparticles are used in the diagnosis and treatment of leukemia. This study aimed to identify author, country, institutional, and journal collaborations and their impacts, assess the knowledge base, identify existing trends, and uncover emerging topics related to leukemia research. 1825 Articles and reviews were obtained from the WoSCC and analyzed by Citespace and Vosviewer. INTERNATIONAL JOURNAL OF NANOMEDICINE is the journal with the highest output. The contribution of FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY is also noteworthy. The three main aspects of research in Nanoparticles-leukemia-related fields included nanoparticles for the diagnosis and treatment of leukemia, related to the type and treatment of leukemia, the specific molecular mechanism, and existing problems of the application of nanoparticles in leukemia. In the future, synthesize nano-drugs that have targeted therapy and chemotherapy resistance according to the mechanism, which may be the dawn of the solution to leukemia. This study offers a comprehensive overview of the Nanoparticles-leukemia-related field using bibliometrics and visual methods for the first time, providing a valuable reference for researchers interested in Nanoparticles-leukemia.
Evaluation of hemodynamic effects of different inferior vena cava filter heads using computational fluid dynamics
Authors: Li Mingrui , Wang Jingying , Huang Wen , Zhou Yue , Song Xue
Published: October 2022

Inferior vena cava (IVC) filters are used to prevent pulmonary embolism in patients with deep vein thrombosis for whom anticoagulation is unresponsive. The head is a necessary structure for an Inferior vena cava filter (IVCF) in clinic use. At present, there are various head configurations for IVCFs. However, the effect of head pattern on the hemodynamics of IVCF is still a matter of unclear. In this study, computational fluid dynamics is used to simulate non-Newtonian blood flows around four IVCFs with different heads inside an IVC model, in which the Denali filter with a solid and hooked head is employed as a prototype, and three virtual variants are reconstructed either with a no-hook head or with a through-hole head for comparison. The simulation results show that the through-hole head can effectively avoid the recirculation region and weaken the blood flow stasis closely downstream the IVCF head. The shape change of the filter head has no significant effect on the blood flow acceleration inside the IVCF cone as well as little influence on the wall shear stress (WSS) distribution on the filter wire surface and IVC wall. The structure pattern of filter head greatly affects the flow resistance of its own. However, the flow drag of filter head only occupies a small proportion of the total resistance of IVCF. Therefore, to reduce the flow resistance of an IVCF should optimize its whole structure.
Red algae industrial residues as a sustainable carbon platform for the co-production of poly-3-hydroxybutyrate and gluconic acid by Halomonas boliviensis
Authors: Bondar Maryna , Pedro Filipa , Oliveira M. Conceição , da Fonseca M. Manuela R. , Cesário M. Teresa
Published: October 2022

Polyhydroxyalkanoate (PHA) production using halophilic bacteria has been revisited because less severe operational conditions with respect to sterility can be applied, also alleviating production costs. Halomonas boliviensis was selected because it is a moderate halophile able to grow and attain high poly-3-hydroxybutyrate (P3HB) contents under 5–45 g/L NaCl concentrations, conditions that discourage microbial contamination. Industrial residues of the red alga Gelidium corneum after agar extraction were used as sugar platform to reduce costs associated with the carbon source. These residues still comprise a high carbohydrate content (30–40% w/w) of mainly cellulose, and their hydrolysates can be used as substrates for the bioproduction of value-added products. Preliminary assays using glucose were carried out to determine the best conditions for growth and P3HB production by H. boliviensis in bioreactor fed-batch cultivations. Two strategies were addressed, namely nitrogen or phosphorus limitation, to promote polymer accumulation. Similar P3HB cell contents of 50% (gpolymer/gCDW) and yields YP3HB/glucose of 0.11–0.15 g polymer/g glucose were attained under both conditions. However, higher specific productivities were reached under P-limitation, and thus, this strategy was adopted in the subsequent study. Two organic acids, resulting from glucose metabolism, were identified to be gluconic and 2-oxoglutaric acid. Reducing the oxygen concentration in the cultivation medium to 5% sat was found to minimize organic acid production and enhance the yield of polymer on sugar to 0.20 gP3HB/gglucose. Finally, fed-batch cultivations using G. corneum hydrolysates as the only C-source achieved an overall volumetric productivity of 0.47 g/(L.h), 40% polymer accumulation, and negligible gluconic acid production.
Strategies for the production of dsRNA biocontrols as alternatives to chemical pesticides
Authors: Hough James , Howard John D. , Brown Stephen , Portwood David E. , Kilby Peter M. , Dickman Mark J.
Published: October 2022

Current crop pest control strategies rely on insecticidal and fungicidal sprays, plant genetic resistance, transgenes and agricultural practices. However, many insects, plant viruses, and fungi have no current means of control or have developed resistance against traditional pesticides. dsRNA is emerging as a novel sustainable method of plant protection as an alternative to traditional chemical pesticides. The successful commercialisation of dsRNA based biocontrols for effective pest management strategies requires the economical production of large quantities of dsRNA combined with suitable delivery methods to ensure RNAi efficacy against the target pest. A number of methods exist for the production and delivery of dsRNA based biocontrols and here we review alternative methods currently employed and emerging new approaches for their production. Additionally, we highlight potential challenges that will need to be addressed prior to widespread adoption of dsRNA biocontrols as novel sustainable alternatives to traditional chemical pesticides.
Establishment of inclusive single-cell transcriptome atlases from mouse and human tooth as powerful resource for dental research
Authors: Hermans Florian , Bueds Celine , Hemeryck Lara , Lambrichts Ivo , Bronckaers Annelies , Vankelecom Hugo
Published: October 2022

Single-cell (sc) omics has become a powerful tool to unravel a tissue’s cell landscape across health and disease. In recent years, sc transcriptomic interrogation has been applied to a variety of tooth tissues of both human and mouse, which has considerably advanced our fundamental understanding of tooth biology. Now, an overarching and integrated bird’s-view of the human and mouse tooth sc transcriptomic landscape would be a powerful multi-faceted tool for dental research, enabling further decipherment of tooth biology and development through constantly progressing state-of-the-art bioinformatic methods as well as the exploration of novel hypothesis-driven research. To this aim, we re-assessed and integrated recently published scRNA-sequencing datasets of different dental tissue types (healthy and diseased) from human and mouse to establish inclusive tooth sc atlases, and applied the consolidated data map to explore its power. For mouse tooth, we identified novel candidate transcriptional regulators of the ameloblast lineage. Regarding human tooth, we provide support for a developmental connection, not advanced before, between specific epithelial compartments. Taken together, we established inclusive mouse and human tooth sc atlases as powerful tools to potentiate innovative research into tooth biology, development and disease. The maps are provided online in an accessible format for interactive exploration.
Advance of genetically modified pigs in xeno-transplantation
Authors: Deng Jiacheng , Yang Lin , Wang Ziru , Ouyang Hongsheng , Yu Hao , Yuan Hongming , Pang Daxin
Published: October 2022

As the standard of living improves, chronic diseases and end-stage organ failure have been a regular occurrence in human beings. Organ transplantation has become one of the hopes in the fight against chronic diseases and end-stage organ failure. However, organs available for transplantation are far from sufficient to meet the demand, leading to a major organ shortage crisis. To solve this problem, researchers have turned to pigs as their target since pigs have many advantages as xenograft donors. Pigs are considered the ideal organ donor for human xenotransplantation, but direct transplantation of porcine organs to humans faces many obstacles, such as hyperacute rejection, acute humoral xenograft rejection, coagulation dysregulation, inflammatory response, coagulation dysregulation, and endogenous porcine retroviral infection. Many transgenic strategies have been developed to overcome these obstacles. This review provides an overview of current advances in genetically modified pigs for xenotransplantation. Future genetic engineering-based delivery of safe and effective organs and tissues for xenotransplantation remains our goal.
Combating challenges in CAR-T cells with engineering immunology
Authors: Wang Clement Yisai , Ting Cheung Stephanie Po , Sugimura Ryohichi
Published: October 2022

Chimeric antigen receptors (CAR) T cells (CAR-T) mark a significant step towards producing safe and effective personal anticancer treatments. CAR-T strategies engineers the T cells from the patients to allow specific binding to a tumour-specific antigen. CAR-Ts are a second-wave offensive strategy to clear out remaining chemotherapy-resistant tumour cells. Though showing practical antitumor abilities in multiple haematological malignancies and solid tumour cancers, the issues of antigen escape, tumour infiltration/penetration, and toxicity side effects limit the usage of prolonged CAR-T therapies. However, engineering immunology has exploited human stem cell-based CAR-T therapies and the development of CAR-M (macrophage) therapies to combat the disadvantages of conventional CAR-T therapies. In this review, we will highlight the challenges of CAR-T therapies and combat them with engineering immunology for cancer immunotherapy.