Informatively cross-correlation aspects of unsuccessful attempts at assisted reproductive technologies
Authors: Kitsok Olha 
Published: January 2024

The objective: increase of efficiency of assisted reproductive technologies (ART) on the basis of lead through cross-correlation analysis them ineffective attempts.

Materials and methods. A basic group was selected with the womanish factors of infertility (100 matrimonial pair with unsuccessful attempts of ART in anamnesis). Thus the following sub-groups were selected in a basic group: pipe peritoneal infertility; endocrine infertility; endometriosis and united factors of infertility. The group comparison was made by 50 women without violations of fertility. For these women, the normal structure of the endometrium was confirmed. The complex conducted research included clinical, endocrinology, and morphological.

Results. The presence of feed-backs of moderate force found between the positive effect of and presence in anamnesis of appendectomy (r=- 0,41), tubectomy (r=-0,37), to the syndrome of polycystic ovaries (r=-0,32), myomectomy (r=-0,35) and laparotomy (r=0,32). The Opposite found the positive copulas of a factor of the offensive of pregnancy after in vitro fertilization with a presence in anamnesis of such patients of information about laparoscopy (r=0,38) and separate diagnostic scraping off (r=0,30). Analyzing the results of ART with the conducted treatment, the frequency of coagulation of hearths of the endometrium for patients with the negative result of in vitro fertilization was 28,2%, more than 2 times, exceeding the proper value in the sub-group of patients with the positive result of ART. The estimation of intercommunication of the positive effect of assisted reproductive technologies with a hormonal factor routined the presence of positive connections of moderate force with the concentrations of hormones of follicle-stimulating hormone (r=0,42), prolactin (r=0,39) and to thetriiodo-thyronine (r=0,31). The connection of the offensive of pregnancy with the level of estradiol was reliable, however weak (r=0,28). Also weak was the connection of the positive effect of ART with the level of receptors of the endometrium to progesterone in the stroma of endometrium (r=0,23), however many correlations with all other indexes of receptors of the endometrium to the steroid hormones were lines, and moderate force: with the receptors of endometrium to progesterone in an epithelium - r=0,42, receptors of endometrium to the estradiol in stroma - r=0,32, receptors to the estradiol in the epithelium of endometrium of r=0,40.

Conclusion. The principal reasons for unsuccessful attempts of ART are protracted infertility, repeated operative interferences on the organs of the small pelvis, a large number of endometrial operations, the presence of endometriosis, and a high infectious index. Except for it, protracted and unsuccessful treatment of infertility in itself is a negative factor that strengthens present violations. These factors of risk are instrumental in derangement adaptation-homoeostatic backlogs of organisms, synchronization inflammation, strengthening anatomical-and-functional defects of the genesis system, that, in the same queue, reduces the genesial potential of patients and instrumental in the unsuccessful attempts of ART. Conducted a cross-correlation analysis routined the substantial role of dishormonal violations and pathology of endometrium in the unsuccessful attempts of ART. The got results must be taken into account in the development of an algorithm for an increase of the efficiency of ART.