bluuebunny/crossref_metadata_2025 huggingface dataset:
The Roles of Primary Emotional Systems and Need Satisfaction in Problematic Internet and Smartphone Use: A Network Perspective
Authors: Rozgonjuk Dmitri , Davis Kenneth L. , Montag Christian
Published: September 2021

Problematic Internet and smartphone use (PIU and PSU, respectively) have received significant attention over the past years. In the current work, we studied the associations between PIU and PSU, primary emotional systems, and need satisfaction. The effective sample comprised 399 people who responded to scales measuring these variables. Bivariate correlation analysis showed that both PSU and PIU were positively associated with negative primary emotion traits (FEAR, ANGER, SADNESS) as well as lower scores on most of the need satisfaction factors. Network analysis showed that while PIU and PSU have a strong association with each other, in general, there were not many significant correlations between PSU, PIU, and other variables in the network. The associations being present were rather weak. Network analysis showed that PSU was positively associated with FEAR, ANGER, PLAY primary emotional systems. Both PSU and PIU had a negative association with safety and security and physiological needs satisfaction. Moreover, PSU had a positive link with belongingness need satisfaction, while higher PIU was associated with lower esteem and self-actualization need satisfaction. Addressing those unmet needs may be helpful in reducing problematic technology use, but further research testing this would be necessary.
On Revelations and Revolutions: Drinking Ayahuasca Among Palestinians Under Israeli Occupation
Authors: Roseman Leor , Karkabi Nadeem
Published: September 2021

The ritualistic use of ayahuasca can induce a feeling of unity and harmony among group members. However, such depoliticized feelings can come in the service of a destructive politicalstatus quoin which Palestinians are marginalized. Through 31 in-depth interviews of Israelis and Palestinians who drink ayahuasca together, and through participatory observations, such rituals were examined. In this setting marginalization was structurally rooted by the group’s inability to recognize Palestinian national identity or admit the ongoing Israeli injustice toward Palestinians. Although the groups avoided politics, they still find their way into these rituals. This happened through occasional ayahuasca-induced revelatory events, in which individuals were confronted with a pressing truth related to the oppressive relations between Jewish Israelis and Palestinians. Three case studies of such revelatory events are described in this paper. Affected by emotions of pain, anger, and guilt, these participants developed resistance toward the hegemonic Israeli ritual structure. This was followed by an urge to deliver an emancipatory message to the rest of the group, usually through a song. Moreover, affected subjects developed a long-lasting fidelity to thetruthattained at these events. In time, this fidelity led to the expansion of ayahuasca practices to other Palestinians and the politicization of the practice. The article draws on Badiou’s theory inBeing and Event(1988) to analyze the relations between the Israeli ritual structure, the Palestinian revelatory event, and the emancipatory fidelity that followed. Badiou’s theory elucidates the egalitarian revolutionary potential, which is part of the sociopsychopharmacology of psychedelics.
Confirming the Reliability and Validity of the Sexual Minority Adolescent Stress Inventory in a National Sample of Sexual Minority Adolescents
Authors: Goldbach Jeremy T. , Schrager Sheree M. , Mamey Mary Rose , Rhoades Harmony
Published: September 2021

Objective: Sexual minority adolescents (SMA) experience numerous behavioral health disparities, including depression, anxiety, substance use, non-suicidal self-injury, and suicidality. The primary framework to understand these disparities is minority stress theory, which frames this disproportionate burden as the result of discrimination, violence, and victimization in a homophobic culture. Empirical examinations of minority stress among SMA have been limited by lack of diverse samples or validated measures. This study engaged a national community sample of SMA to confirm reliability and validity of the Sexual Minority Adolescent Stress Inventory (SMASI).

Method: A national sample of 2,310 SMA aged 14–17 was recruited in the United States through a hybrid social media and respondent-driven sampling approach. Item response theory and confirmatory factor analysis established the psychometric properties of the SMASI in this sample; minority stress was modeled as a latent variable in several regression models to verify criterion and divergent validity.

Results: In this national sample (M age = 15.9; 64% female and 60% White), the factor structure of the SMASI and its 11 subscales was confirmed and shown to be invariant by demographic characteristics. Minority stress as measured by the SMASI was significantly associated with all mental and behavioral health outcomes.

Conclusions: This study provides evidence that SMASI is a reliable, valid, and important tool for better understanding minority stress and subsequent health and mental health consequences among SMA.
Validation of the Structured Interview for the Assessment of Expressed Emotion (E5) in a Sample of Adolescents and Young Adults From the General Population
Authors: Muela-Martinez Jose-Antonio , Espinosa-Fernandez Lourdes , Garcia-Lopez Luis-Joaquin , Martin-Puga Maria-Eva
Published: September 2021

Expressed emotion (EE) is an index of significant others’ attitudes, feelings, and behavior toward an identified patient. EE was originally conceptualized as a dichotomous summary index. Thus, a family member is rated low or high on how much criticism, hostility, and emotional overinvolvement (EOI) s/he expresses toward an identified patient. However, the lack of brief, valid measures is a drawback to assess EE. To cover this gap, the E5 was designed. The objective of this study is to provide psychometric properties of a recent measured in adolescents to be used to tap perceived high levels of EE. The sample was composed by 2,905 adolescents aged from 11–19years; 57% girls. Results demonstrate good factor structure, reliability, construct validity and invariance across gender and age revealed a good fit. As a result, E5 is a brief, valid and reliable measure for assessing expressed emotion in parents of adolescent children.
The Relations of Parental Autonomy Support, Parental Control, and Filial Piety to Chinese Adolescents’ Academic Autonomous Motivation: A Mediation Model
Authors: Guo Mingchun , Wang Long , Day Jamin , Chen Yanhan
Published: September 2021

This study attempted to examine the mediating role of filial piety in the relationships between parental autonomy support and control and Chinese adolescents’ academic autonomous motivation. A set of questionnaires were administered to 492 adolescent students at two senior high schools in Fuzhou, China. Confirmatory Factor Analysis and Structural Equation Modeling were employed to analyze the data. The results showed that reciprocal filial piety (RFP) fully mediated the relationships of parental autonomy support and behavioral control with adolescents’ academic autonomous motivation. RFP did not significantly mediate the relationship between psychological control and academic autonomous motivation. Comparatively, authoritarian filial piety (AFP) did not play a significant mediating role in the relationship between the three parenting dimensions and adolescents’ academic autonomous motivation. The findings provide a new perspective for understanding the relationship between parenting behaviors and Chinese adolescents’ academic autonomous motivation.
High School Students' Online Learning Ineffectiveness in Experimental Courses During the COVID-19 Pandemic
Authors: Hong Jon-Chao , Liu Yue , Liu Yinsheng , Zhao Li
Published: September 2021

Due to the COVID-19 pandemic, online learning has been adopted in all stages of education. This sudden change from traditional learning to 100% online learning may affect students' learning effectiveness, especially in experimental courses. However, there has been little discussion of experimental courses conducted entirely through online learning. To address this gap, the present study investigated factors affecting high school students' online learning ineffectiveness (OLI) in online experimental courses, particularly online science experimental courses. The role of gender was also explored to understand whether it affects participants' OLI. An ANOVA was conducted to analyze the data from a survey of 347 online learners in high schools. The results indicated that the number of online experimental courses and the duration of online hands-on learning were negatively related to the high school students' OLI. Meanwhile, the study found that the high school participants' OLI differed by gender, with female students more likely than males to have OLI in the context of online learning. The results of this study can provide a reference for teachers who conduct online experimental courses and wish to improve their online teaching, not only during the COVID-19 lockdown, but also in other pandemic periods.
A Perspective on the Integration of eHealth in Treatment of Offenders: Combining Technology and the Risk-Need-Responsivity Model
Authors: Kip Hanneke , Bouman Yvonne H. A.
Published: September 2021

While there are multiple ways in which eHealth interventions such as online modules, apps and virtual reality can improve forensic psychiatry, uptake in practice is low. To overcome this problem, better integration of eHealth in treatment is necessary. In this perspective paper, we describe how the possibilities of eHealth can be connected to the risk-need-responsivity (RNR) model. To account for the risk-principle, stand-alone eHealth interventions might be used to offer more intensive treatment to high-risk offenders. The need-principle can be addressed by connecting novel experience-based interventions such as VR and apps to stable and acute dynamic risk factors. Finally, using and combining personalized interventions is in line with the responsivity-principle. Based on research inside and outside of forensic psychiatry, we conclude that there are many possibilities for eHealth to improve treatment—not just based on RNR, but also on other models. However, there is a pressing need for more development, implementation and evaluation research.
Millipore xMap® Luminex (HATMAG-68K): An Accurate and Cost-Effective Method for Evaluating Alzheimer's Biomarkers in Cerebrospinal Fluid
Authors: Hansen Erika Oliveira , Dias Natalia Silva , Burgos Ivonne Carolina Bolaños , Costa Monica Vieira , Carvalho Andréa Teixeira , Teixeira Antonio Lucio , Barbosa Izabela Guimarães , Santos Lorena Aline Valu , Rosa Daniela Valadão Freitas , Ribeiro Aloisio Joaquim Freitas , Viana Bernardo Mattos , Bicalho Maria Aparecida Camargos
Published: September 2021

Background: Alzheimer's disease (AD) biomarkers are of great relevance in clinical research, especially after the AT(N) framework. They enable early diagnosis, disease staging and research with new promising drugs, monitoring therapeutic response. However, the high cost and low availability of the most well-known methods limits their use in low and medium-income countries. In this context, Millipore xMap® Luminex may be a cost-effective alternative. In our study, using INNOTEST® as reference, we assess the diagnostic accuracy of Millipore xMap® and propose a cutoff point for AD.

Methods: We performed lumbar puncture of seven older individuals with clinically defined AD, 17 with amnestic mild cognitive impairment (aMCI) and 11 without objective cognitive impairment-control group (CG). Cerebrospinal fluid (CSF) biomarkers concentrations for aB42, p-Tau, and t-Tau were measured by INNOTEST® and Millipore xMap®, and then the techniques were compared to assess the diagnostic accuracy of the new test and to define a cutoff.

Results: INNOTEST® and Millipore xMap® measurements showed all correlations >0.8 for the same biomarker, except for t-Tau that was 0.66. Millipore xMap® measurements showed a robust accuracy for all biomarkers, with AUC higher than 0.808 (t-Tau), and the best for Aβ42 (AUC = 0.952). The most accurate cutoffs were found at 1012.98 pg/ml (Aβ42), 64.54 pg/ml (p-tau), 3251.81 pg/ml (t-tau), 3.370 (t-Tau/Aβ42), and 0.059 (p-Tau/Aβ42).

Conclusion: Given its good accuracy and cost-effectiveness, Milliplex xMap® tests seems a reliable and promising tool, especially for low and middle-income countries.
Documenting Behavioral Health Needs in an Urban Setting
Authors: Hudson Darrell , McCrary Stacey , Murugan Vithya , Gerassi Lara , Proctor Enola K.
Published: September 2021

Most local communities lack the capacity to conduct behavioral health needs assessments. The purpose of this paper is to describe a mixed-methods approach to estimate the behavioral health needs in St. Louis, MO. Data were drawn from multiple sources including local and state government prevalence estimates, medical records, and key informant interviews. The most prevalent behavioral conditions were depression, alcohol, and drug abuse. Priority populations were residents with co-occurring disorders, youth transitioning into the adult behavioral system, and homeless individuals with behavioral health needs. Treatment rates for behavioral health conditions were low, relative to identified needs. There are significant provider shortages and high staff turnover, which extend wait times, diminish the quality of care, and contribute to the use of emergency departments for behavioral health care. The data and methods described in this paper could be helpful to other municipalities that are looking to conduct behavioral health needs assessments.
Effectiveness and Preparedness of Institutions' E-Learning Methods During the COVID-19 Pandemic for Residents' Medical Training in Saudi Arabia: A Pilot Study
Authors: Alsaywid Basim , Lytras Miltiadis D. , Abuzenada Maha , Lytra Hara , Sultan Lama , Badawoud Hala , Abuznadah Wesam , Alhaider Sami A. , Housawi Abdulrahman , Apostolaki Areti
Published: September 2021

Background:Under the urgent circumstances of the COVID-19 pandemic, higher education institutions of an international scale have resorted to online education methods, exclusive or not. Among those, medical institutions are under double pressure, fighting the pandemic's effects and, at the same time providing efficient clinical training to their residents. The main aim of the study is to evaluate the preparedness of the educational institutions for the e-learning platform transition for the delivery of medical training and also to evaluate the overall satisfaction level of the participants with their e-learning experience.

Methods:This is an observational cross-sectional study design. The survey's sample included 300 medical students and residents of multiple training levels and specialties, coming from more than 15 different cities of Saudi Arabia. Filling the questionnaire required specific inclusion criteria and all obtained data were secured by the Saudi Commission of Health specialty. The main objective was to evaluate the quality of e-learning methods provided by medical universities. For the collection of the data, Survey Monkey software was used and the analysis was conducted with SPSS.

Results:The study found that the frequency of digital education use increased by ~61% during the coronavirus crisis, while almost 9 out of 10 residents have used some e-learning platform. It was reported that before the pandemic, participants' online training was deemed to be rather ineffective, given the rate of 3.65 out of 10. However, despite the increase in e-learning use after COVID-19, many obstacles arose duringcthe adaptation process. According to our survey: lectures and training sessions were not conducted as per the curriculum (56.33%); both students and instructors' academic behavior and attitude changed (48.33%); engagement, satisfaction, and motivation in class were rated low (5.93, 6.33, and 6.54 out of 10 accordingly), compared to the desired ones. Still, participants accredited e-learning as a potential mandatory tool (77.67%) and pinpointed the qualifications that in their opinion will maximize educational impact.

Conclusion:The study concluded that innovative restructuring of online education should be based on defined critical success factors (technical support, content enhancement, pedagogy etc.) and if possible, set priority levels, so that a more permanent e-learning practice is achievable. Also our study confirmed that students were overall satisfied with the e-learning support of the training method.
The Burden of Obesity in Egypt
Authors: Aboulghate Mohamed , Elaghoury Aliaa , Elebrashy Ibrahim , Elkafrawy Nabil , Elshishiney Galal , Abul-Magd Ehab , Bassiouny Engy , Toaima Dalia , Elezbawy Baher , Fasseeh Ahmad , Abaza Sherif , Vokó Zoltán
Published: September 2021

Objective: Estimating the burden of obesity to society is an essential step in setting priorities and raising awareness. We aimed to assess the clinical, humanistic and economic burden of obesity for adults in Egypt.

Methods: We used the population attributable fraction concept to estimate the burden. A non-systematic review was conducted to estimate the prevalence of obesity and its comorbidities in addition to the obesity attributable fraction. Patient numbers, direct healthcare costs, disability adjusted life years (DALYs) and attributable mortality were estimated.

Results: Obesity is a major contributor to the development of diabetes mellitus, hypertension, obstructive sleep apnea and fatty liver, in addition to several serious diseases. The estimated annual deaths due to obesity was about 115 thousand (19.08% of the total estimated deaths in 2020). DALYs attributable to obesity may have reached 4 million in 2020.The economic burden imposed by obesity is around 62 Billion Egyptian pounds annually. This value is the cost of treating diseases attributable to obesity in adults.

Conclusions: Diseases attributable to obesity create a huge economic, humanistic, and clinical burden in Egypt. Reducing obesity could help dramatically decrease the catastrophic health effect of these diseases which in turn decreases mortality and DALYs lost.
Evolving Trends and Research Hotspots in Disaster Epidemiology From 1985 to 2020: A Bibliometric Analysis
Authors: Liu Tao , Liu Xin , Li Yue , Liu Shuyu , Cao Chunxia
Published: September 2021

Background: Disaster epidemiology has not attracted enough attention in the past few decades and still faces significant challenges. This study aimed to systematically analyze the evolving trends and research hotspots in disaster epidemiology and provide insights into disaster epidemiology.

Methods: We searched the Scopus and Web of Science Core Collection (WoSCC) databases between 1985 and 2020 to identify relevant literature on disaster epidemiology. The retrieval strategies were TITLE-ABS-KEY (disaster epidemiology) and TS = (disaster AND epidemiology). Bibliometrix, VOSviewer 1.6.6 and SigmaPlot 12.5 were used to analyze the key bibliometric indicators, including trends and annual publications, the contributions of countries, institutions, journals and authors, and research hotspots.

Results: A total of 1,975 publications were included. There was an increasing trend in publications over the past 35 years. The USA was the most productive country. The most frequent institutions and journals were Fukushima Medical University and Prehospital and Disaster Medicine. Galea S made significant contributions to this field. “Epidemiology” was the highest-frequency keyword. COVID-19 was highly cited after 2019. Three research hotspots were identified: (i) the short- and long-term adverse health effects of disasters on the population; (ii) COVID-19 pandemic and emergency preparedness; and (iii) disaster management.

Conclusions: In recent decades, the USA was a global leader in disaster epidemiology. Disaster management, the short- and long-term health effects of disasters, and the COVID-19 pandemic reflected the research focuses. Our results suggest that these directions will remain research hotspots in the future. International collaboration is also expected to widen and deepen in the field of disaster epidemiology.
Cost-Effectiveness of Dronedarone and Amiodarone for the Treatment of Chinese Patients With Atrial Fibrillation
Authors: Zhang Mengran , Ren Yu , Wang Luying , Jia Jianhao , Tian Lei
Published: September 2021

Background: Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice, which brings great economic burden to patients. This study evaluated the economics of the new antiarrhythmic drug dronedarone and provides suggestions for allocation of health resources.

Methods: Amiodarone was selected as the control group, and the Markov model of AF was established using nine states. The total cost and quality-adjusted life year (QALY) of dronedarone and amiodarone groups were calculated and compared. The incremental cost effectiveness ratio (ICER) value was calculated and compared with the willingness to pay (WTP) and the sensitivity analyses was conducted.

Results: For China's healthcare system, the ICER of the dronedarone group compared with the amiodarone group was RMB 81,741 Yuan/QALY, which is lower than the current recommended WTP (3 times GDP per capita). Sensitivity analyses showed that the model was robust, and the drug price of dronedarone significantly impacted the results.

Conclusions: Compared with amiodarone, dronedarone is more economical in the Chinese healthcare system. However, due to the lack of data on the Chinese population for some parameters, the model needs further improvement and discussion. Real-world studies on the effects of dronedarone on Chinese patients with AF would be beneficial.
Does a Sense of Social Presence During Conversation Affect Student's Shared Memory? Evidence From SS-RIF Paradigm
Authors: Zhu Lin , Zhang Jinkun
Published: September 2021

People constantly talk to one another about the past, and in so doing, they recount certain details while remaining silent about others. Collaborative or conversational remembering plays an important role in establishing shared representations of the past (e.g., the 911 attacks, Covid-19). According to the socially shared retrieval-induced forgetting (SS-RIF) effect, a listener will forget about relevant but unpracticed information during communication, due to intentional or unintentional selective retrieval of data by the speaker. The SS-RIF paradigm has been applied to explain how collective memory is shaped within the context of conversation/discourse. This study sought to determine if SS-RIF occurred only during face-to-face communication, or whether shared memories could be developed through other types of conversation quite common in modern society. We also investigated whether a level of social interaction in the real-world presence of others is a necessary condition for inducing SS-RIF, and if listeners experience different degrees of SS-RIF due to different levels of perceived social presence. We observed the SS-RIF phenomenon in listeners both in real life and video; the degree of forgetting was the same for the two conditions. These results indicate that social presence may not be associated with SS-RIF. Public silence affects the formation of collective memory regardless of the face-to-face presence of others, and thus physical presence is not necessary to induce SS-RIF.
Implementation of a Commitment Machine for an Adaptive and Robust Expected Shortfall Estimation
Authors: Bagnato Marco , Bottasso Anna , Giribone Pier Giuseppe
Published: September 2021

This study proposes a metaheuristic for the selection of models among different Expected Shortfall (ES) estimation methods. The proposed approach, denominated “Commitment Machine” (CM), has a strong focus on assets cross-correlation and allows to measure adaptively the ES, dynamically evaluating which is the most performing method through the minimization of a loss function. The CM algorithm compares four different ES estimation techniques which all take into account the interaction effects among assets: a Bayesian Vector autoregressive model, Stochastic Differential Equation (SDE) numerical schemes with Exponential Weighted Moving Average (EWMA), a Generalized AutoRegressive Conditional Heteroskedasticity (GARCH) volatility model and a hybrid method that integrates Dynamic Recurrent Neural Networks together with a Monte Carlo approach. The integration of traditional Monte Carlo approaches with Machine Learning technologies and the heterogeneity of dynamically selected methodologies lead to an improved estimation of the ES. The study describes the techniques adopted by the CM and the logic behind model selection; moreover, it provides a market application case of the proposed metaheuristic, by simulating an equally weighted multi-asset portfolio.
Meaningful Transfer: Tech-Knowlogical Interdependencies in the Digital Built Environment
Authors: Muldoon-Smith Kevin , Moreton Leo , Kotter Richard
Published: September 2021

This paper engages with ideas of tacit and explicit knowledge, how it is created, transferred, and ultimately translated in contemporary discourses of the digital built environment. The aim is to open a more critical and original dialogue in the digital built environment by (a) interrogating digital innovation as it strives to utilise relatively distilled information to enhance the sustainable design, construction and operation of the built environment and wider urban areas, (b) representing the rights of those whose knowledge is created and transferred in the digital built environment and (c) by further understanding the context of knowledge creation, and thus maximising its potential for scaling up sustainability objectives. The paper considers the conceptual and methodological tools that may help to focus more novel analysis of knowledge production and transfer in the digital built environment. The paper considers three conceptual positions that have hitherto been considered either in isolation or only tangentially connected to each other: (1) Science and Technology Studies (STS), in order to understand how society and technology is intertwined and importantly to form a meaningful backdrop for engagement with knowledge; (2) Organisational Theory (OT) and the concept of “pipelines,” in order to understand how organisations—and more broadly cities—can meaningfully capture and utilise knowledge when transitioning to digitally enabled sustainable futures; (3) Aspects of Actor Network Theory (ANT), in order to understand how knowledge travels and gets translated and institutionalised in new domains. Furthermore, we also use the same conceptual positions to argue how following knowledge can help individuals and society navigate the digital built environment. Our findings suggest that smart technology is a “social prosthesis,” and only works because humans make up for its deficiencies.
Gut Coaching: How Immune Cells Become Superheroes…or Villains!
Authors: Garrido-Mesa José , Garrido-Barros Maria
Published: September 2021

The gut is home to millions of microscopic organisms, which together are called the gut microbiota. Most of these microorganisms live in peace with the rest of our cells, help us get energy from food, and give us essential nutrients that we cannot make ourselves. The cells lining the gut’s surface keep these microorganisms separated from the rest of the body, like the “Great Wall” of our kingdom. On the inside of this Great Wall, the heroes of the mighty immune system watch over and protect us. But how can the immune system tell the difference between our own cells and the gut microorganisms? Or between helpful microorganisms and disease-causing ones? It is an amazing storey, full of secrets. In this article, we will explain how the gut coaches the immune system to recognise enemies, and how some aspects of modern life might be interfering with this process.
Household Coping Strategies During the COVID-19 Pandemic in Chile
Authors: Palma Julieta , Araos Consuelo
Published: September 2021

Chile was severely hit by the COVID-19 pandemic. The implementation of social distancing measures strongly affected the Chilean economy: the unemployment rate grew rapidly as well as the proportion of population temporarily excluded from the labour force. This article analyses the strategies deployed by Chilean households to cope with the impact of the pandemic at the intersection with household structure and its socio-economics characteristics. Secondary data analysis from the Encuesta Social COVID-19 (COVID-19 Social Survey), carried out by the Chilean Ministry for Social Development and Families, were used to analyse the income-generating and expenditure-minimising strategies adopted by households during the early months (March to July of 2020) of the pandemic. The results show that 60.3% of households experienced a drop in family income, 70.3% indicated that they had to use at least one income-generating strategy, and 76.6% at least one expenditure-minimising strategy during the early months of the pandemic. Indebtedness and decapitalisation characterised most of the coping strategies adopted by households. While living in multigenerational households does not protect family members from declining economic well-being, older people living in one- and two-generation households were found to be least affected economically during the crisis. They were also less likely to resort to these coping strategies, insofar as their income was mainly secured from pensions. Although female-headed households did not show a greater reduction in income than male-headed households, they were more likely to adopt income-generating strategies. This article draws attention to the possible effects of decapitalisation and indebtedness on the long-term economic well-being of households with different structures, and the resulting inequalities in their capacity to recover from the effects of the pandemic. The findings suggest that having a source of family income that is not dependent on labour market flows is crucial in times of crises.
Gender Differences and Lost Flexibility in Online Freelancing During the COVID-19 Pandemic
Authors: Dunn Michael , Munoz Isabel , Sawyer Steve
Published: September 2021

We report findings from an ongoing panel study of 68 U.S.-based online freelancers, focusing here on their experiences both pre- and in-pandemic. We see online freelancing as providing a window into one future of work: collaborative knowledge work that is paid by the project and mediated by a digital labor platform. The study’s purposive sampling provides for both empirical and conceptual insights into the occupational differences and career plans of freelance workers. The timing of the 2020 data collection provides insight into household changes as a result of the COVID-19 pandemic. Findings make clear these workers are facing diminished work flexibility and increased earning uncertainty. And, data show women are more likely than men to reduce working hours to help absorb the increased share of caregiving and other domestic responsibilities. This raises questions of online freelancing as a viable career path or sustainable source of work.
Neural Network Reconstruction of Plasma Space-Time
Authors: Bard C. , Dorelli J.C.
Published: September 2021

We explore the use of Physics-Informed Neural Networks (PINNs) for reconstructing full magnetohydrodynamic solutions from partial samples, mimicking the recreation of space-time environments around spacecraft observations. We use one-dimensional magneto- and hydrodynamic benchmarks, namely the Sod, Ryu-Jones, and Brio-Wu shock tubes, to obtain the plasma state variables along linear trajectories in space-time. These simulated spacecraft measurements are used as constraining boundary data for a PINN which incorporates the full set of one-dimensional (magneto) hydrodynamics equations in its loss function. We find that the PINN is able to reconstruct the full 1D solution of these shock tubes even in the presence of Gaussian noise. However, our chosen PINN transformer architecture does not appear to scale well to higher dimensions. Nonetheless, PINNs in general could turn out to be a promising mechanism for reconstructing simple magnetic structures and dynamics from satellite observations in geospace.
Validity and Reliability of the Computrainer Lab™ During Simulated 40 and 100 km Time-Trials
Authors: Jeker David , Gosselin Jonathan , Drouet Jean-Marc , Goulet Eric D. B.
Published: September 2021

The validity and reliability of the Computrainer Lab™ (CT) was assessed, for the first time, using a high-precision motor-driven calibration rig during simulated variable intensity 40 and 100 km time-trials (TTs). The load patterns imposed by the CT were designed from previously published studies in trained cyclists and included multiple 1 or 4 km bursts in power output. For the 40 and 100 km TTs, cluster-based analyses revealed a mean measurement error from the true workload of respectively 0.7 and 0.9%. However, measurement errors were dependent upon the workload variations, fluctuating from 0.2 to 5.1%. Average biases between repeated trials were contained within ± 1.1% for both TTs. In conclusion, using 40 and 100 km TTs containing 1 or 4 km bursts in power output, the present results indicate that (1) the CT can reliably be used by scientists to determine differences between research interventions; (2) the CT provides valid results of power output when data are being analyzed as a whole to derive one mean value of power output and; (3) variations in workload make it difficult to determine at any one time the veracity of the true power output produced by the athlete.
Why Test Purchased Cattle in BVDV Control Programs?
Authors: Van Duijn Linda , Santman-Berends Inge , Biesheuvel Marit , Mars Jet , Waldeck Frederik , van Schaik Gerdien
Published: September 2021

Bovine viral diarrhea (BVD) is controlled in many countries by detection and culling of persistently infected (PI) animals. The most important risk factor for BVDV introduction is purchase. An introduced cow can be PI and transmit the virus to other cattle in the herd. If she is not PI but is pregnant, there is still a risk because the subsequently born calf may be PI, when she encountered the virus in early pregnancy. To control this risk, all cows > 1 year from non-BVDV-free herds that are introduced in herds that participate in the Dutch BVDV control program are tested for virus and antibodies. Depending on the results, subsequent measures such as suspension of the BVDV-free status, removing the animals from the herd, or testing the off-spring of the cow for virus, are undertaken. The aim of this study was to evaluate the results of this risk mitigating measure. Data on cattle movements, calving's, herd-level BVDV status, and animal-level test data were available from all dairy herds that participated in the national BVDV control program (>14,000 dairy herds) for the year 2019. The data were combined and parameters of interest were calculated, i.e., (i) the number of purchased BVD virus positive cattle and (ii) the number of BVD virus positive calves born from purchased cows within 9 months after introduction. In 2019, 217,301 cattle were introduced in Dutch dairy herds that participated in the BVDV control program. Of these, 49,820 were tested for presence of BVD virus and 27 (0.05%) cows introduced in 21 different herds tested BVD virus positive. Out of 46,727 cattle that were tested for antibodies, 20.5% tested positive. The seropositive cows produced 4,341 viable calves, of which 3,062 were tested for virus and subsequently, 40 (1.3%) were found BVD virus positive. These 40 BVD virus positive calves were born in 23 herds. The risk mitigating measure led to detection of 67 BVD virus positive animals in 44 unique herds in 2019. This study makes plausible that the probability and impact of re-introduction of BVDV can be minimized by testing introduced cattle and their subsequently born calves.
Modeling the Spread of Porcine Reproductive and Respiratory Syndrome Among Pig Farms in Lira District of Northern Uganda
Authors: Hasahya Emmanuel , Thakur Krishna K. , Dione Michel M. , Wieland Barbara , Oba Peter , Kungu Joseph , Lee Hu Suk
Published: September 2021

Porcine Reproductive and Respiratory Syndrome (PRRS) is a viral swine disease that causes reproductive failure in breeding sows and respiratory distress in growing pigs. The main objectives were to simulate the transmission patterns of PRRS in Uganda using North American Animal Disease Spread Model (NAADSM) and to evaluate the potential effect of prevention and control options such as vaccination and movement control. The median number of infectious farms at the end of 52 weeks for the baseline scenario was 735 (36.75% of the 2,000 farms). The best effects of vaccination were observed in scenarios 60% farm coverage and 80% farm coverage, which resulted in 82 and 98.2% reduction in the median number of infectious farms at the end of the simulation, respectively. Vaccination of all medium and large farms only (33% of the farms) resulted in a 71.2% decrease in the median number of infectious farms at the end of 52 weeks. Movement control (MC) results showed that the median number of infectious farms at the end of 52 weeks decreased by 21.6, 52.3, 79.4, and 92.4% for scenarios MC 20, MC 40, MC 60, and MC 80%, respectively. This study provides new insights to the government of Uganda on how PRRS can be controlled. The large and medium farms need to be prioritized for vaccination, which would be a feasible and effective way to limit the spread of PRRS in Uganda. Scavenging pigs should be confined at all times, whether in the presence or absence of any disease outbreaks.
Effects of in ovo Injection of Astragalus Polysaccharide on the Intestinal Development and Mucosal Immunity in Broiler Chickens
Authors: Yang Shu-bao , Qin Yan-jun , Ma Xin , Luan Wei-min , Sun Peng , Ju An-qi , Duan Ao-yi , Zhang Ying-nan , Zhao Dong-hai
Published: September 2021

The purpose of this study was to examine the effects of in ovo injection of Astragalus polysaccharide (APS) on hatchability, body weight (BW), intestinal histomorphology, the number of IgA+ cells and sIgA content in intestine, and the expression of intestinal immune-related genes in broiler chickens. On day 18 of the incubation, a total of 960 live embryo eggs were weighed and randomly divided into 4 treatment groups: a control group and three APS groups. The eggs in the control group were injected with 0.5 mL physiological saline. The eggs in the APS groups were injected with 3 different amounts of APS in 0.5 mL physiological saline: 1 mg (APSL), 2 mg (APSM) and 4 mg (APSH). The solution was injected into the amnion of each egg. The results showed that in ovo injection of APS did not affect the hatchability but increased the body weight of the 14 d and 21 d chickens, with a significant increase observed in the APSM group (P < 0.05). At most time points, the villus height (VH) was increased (P < 0.05) and the crypt depth (CD) was decreased (P < 0.05) in the small intestine of the broilers, with higher VH/CD ratios in the APSL and APSM groups compared with the control group. The number of IgA+ cells in the mucosa and the secretory immunoglobulin A (sIgA) levels in the intestinal washings were higher in the APSM and APSH groups than in the APSL and control groups. The gene expression levels of interleukin (IL)-2, interleukin (IL)-4, interferon gamma (IFN-γ), and Toll-like receptor (TLR)-4 were significantly enhanced by APS stimulation at most time points (P < 0.05). These results indicated that in ovo injection of APS has the potential of promoting intestinal development and enhancing intestinal mucosal immunity of broiler chickens in the early stage after hatching.
Measurement Method and Experimental Analysis of Liquid Entrainment for a Flooded Evaporator of a Water-Cooled Centrifugal Chiller Based on Energy Balance
Authors: Huang Xinghua , Zhang Yunqian , Li Zuqiang , Lin Yaolin
Published: September 2021

Liquid entrainment in a flooded evaporator has an important impact on the performance and safety of a water-cooled centrifugal chiller. In this paper, two methods for measuring the liquid entrainment factor in the evaporator of a centrifugal chiller based on energy balance are proposed. Method 1 involves only the heat exchange capacity of the evaporator and Method 2 involves both evaporator and condenser. The applicable conditions of the methods are discussed. Experimental measurements on the flooded evaporator of a single-stage water-cooled centrifugal chiller with refrigerant R134a show that, for a system with good thermal balance, there is little difference in the entrainment factor values obtained by the two methods. Method 2 was found to have slightly higher measurement accuracy, compared to Method 1. The uncertainty propagation analysis shows that for Method 2, the inlet and outlet water temperatures of the evaporator and condenser, motor input power, motor efficiency, transmission power loss and compressor suction and discharge temperatures are important factors. The experimental results show that the variation of the evaporator entrainment factor with refrigerant charge amount is different for different cooling capacity. At 700 and 800 refrigeration ton (RT), the entrainment factor of the test evaporator increases with the increase of refrigerant charge and the growth rate gradually accelerates. For the chiller tested, when the entrainment factor reaches 0.89% and 1.02%, respectively, at 700 ton and 800 ton, the rapid increase of the entrainment factor leads to a significant decrease in the coefficient of performance (COP) during the charging process. Based on the analysis of the experimental results, it is recommended that the maximum entrainment factor for efficient operation of the centrifugal chiller should be controlled within 1%.
Biological Evaluation of Alkyl Triphenylphosphonium Ostruthin Derivatives as Potential Anti-Inflammatory Agents Targeting the Nuclear Factor κB Signaling Pathway in Human Lung Adenocarcinoma A549 Cells
Authors: Vo Nghia Trong , Kusagawa Eiichi , Nakano Kaori , Moriwaki Chihiro , Miyake Yasunobu , Haruyama Sayaka , Fukuhara Sayuri , Nguyen Nhan Trung , Dang Phu Hoang , Nguyen Mai Thanh Thi , Kataoka Takao
Published: September 2021

Ostruthin (6-geranyl-7-hydroxycoumarin) is one of the constituents isolated from Paramignya trimera and has been classified as a simple coumarin. We recently reported the synthesis of alkyl triphenylphosphonium (TPP) derivatives from ostruthin and evaluated their anticancer activities. In the present study, we demonstrated that alkyl TPP ostruthin derivatives inhibited the up-regulation of cell-surface intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with tumor necrosis factor-α (TNF-α) without affecting cell viability, while ostruthin itself exerted cytotoxicity against A549 cells. The heptyl TPP ostruthin derivative (termed OS8) attenuated the up-regulation of ICAM-1 mRNA expression at concentrations higher than 40 µM in TNF-α-stimulated A549 cells. OS8 inhibited TNF-α-induced nuclear factor κB (NF-κB)-responsive luciferase reporter activity at concentrations higher than 40 µM, but did not affect the translocation of the NF-κB subunit RelA in response to the TNF-α stimulation at concentrations up to 100 µM. A chromatin immunoprecipitation assay showed that OS8 at 100 µM prevented the binding of RelA to the ICAM-1 promoter. We also showed that OS8 at 100 µM inhibited the TNF-α-induced phosphorylation of RelA at Ser 536. Moreover, the TNF-α-induced phosphorylation of an inhibitor of NF-κB α and extracellular signal-regulated kinase was reduced by OS8. These results indicate that OS8 has potential as an anti-inflammatory agent that targets the NF-κB signaling pathway.
Clotrimazole Fluidizes Phospholipid Membranes and Localizes at the Hydrophobic Part near the Polar Part of the Membrane
Authors: Ausili Alessio , Yakymenko Illya , Teruel José A. , Gómez-Fernández Juan C.
Published: September 2021

Clotrimazole (1-[(2-chlorophenyl)-diphenylmethyl]-imidazole) is an azole antifungal drug belonging to the imidazole subclass that is widely used in pharmacology and that can be incorporated in membranes. We studied its interaction with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) phospholipid vesicles by using differential scanning calorimetry and found that the transition temperature decreases progressively as the concentration of clotrimazole increases. However, the temperature of completion of the transition remained constant despite the increase of clotrimazole concentration, suggesting the formation of fluid immiscibility. 1H-NMR and 1H NOESY MAS-NMR were employed to investigate the location of clotrimazole in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) phospholipid membranes. In the presence of clotrimazole, all the resonances originating from POPC were shifted upfield, but mainly those corresponding to C2 and C3 of the fatty acyl, chains suggesting that clotrimazole aromatic rings preferentially locate near these carbons. In the same way, 2D-NOESY measurements showed that the highest cross-relaxation rates between protons of clotrimazole and POPC were with those bound to the C2 and C3 carbons of the fatty acyl chains. Molecular dynamics simulations indicated that clotrimazole is located near the top of the hydrocarbon-chain phase, with the nitrogen atoms of the imidazole ring of clotrimazole being closest to the polar group of the carbonyl moiety. These results are in close agreement with the NMR and the conclusion is that clotrimazole is located near the water–lipid interface and in the upper part of the hydrophobic bilayer.
Enhanced Hot Salt-Water Corrosion Resistance of NiCoCrAlY-AlSiY Coating by Ion-Beam-Assisted Deposition
Authors: Xue Guanming , Wang Zhiguo , Wang Enlei , Tang Yan , Zhao Yanhui , Wang Yihe , Hu Suying , Xiang Lin , Xie Zhiwen
Published: September 2021

A promising ion-beam-assisted deposition (IBAD) method was developed to improve the salt-water corrosion resistance of NiCoCrAlY-AlSiY coating. During hot salt-water exposure, hydrochloric acid (HCl) was produced when chloride salt, water, and metal oxide reacted with each other, while HCl was also produced when chlorine reacted with water. The as-deposited AlSiY layer exhibited a loose texture accompanied by numerous pore defects, which triggered the multi-scale diffusion of HCl, resulting in the large-area corrosion degradation of the coating texture and the rapid diffusion of the NiCoCrAlY bonding layer. By contrast, the ion-beam-assisted AlSiY layer showed a dense texture that effectively inhibited the inner diffusion of HCl and suppressed the corrosion reactions as well as the diffusion of the NiCoCrAlY bonding layer. The current results confirmed the significant potential of IBAD in inhibiting corrosion damage and diffusion of thermal protective coatings.