bluuebunny/crossref_metadata_2025 huggingface dataset:
Cross-Sectional Associations of Body Adiposity, Sedentary Behavior, and Physical Activity with Hemoglobin and White Blood Cell Count
Authors: Koivula Tiia , Lempiäinen Salla , Laine Saara , Sjöros Tanja , Vähä-Ypyä Henri , Garthwaite Taru , Löyttyniemi Eliisa , Sievänen Harri , Vasankari Tommi , Knuuti Juhani , Heinonen Ilkka H. A.
Published: November 2022

Background: This study examined whether hemoglobin (Hb) and white blood cell count (WBC) associate with body adiposity and other cardiometabolic risk factors, as well as accelerometer-measured sedentary behavior (SB) and physical activity (PA), when adjusted for body mass index (BMI). Methods: The cross-sectional analysis included 144 participants (42 men) with a mean age of 57.0 years and a mean BMI of 31.7 kg/m2. SB and standing time, breaks in sedentary time and PA were measured during four consecutive weeks with hip-worn accelerometers. A fasting blood sample was collected from each participant during the 4-week measurement period and analyzed using Sysmex XN and Cobas 8000 c702 analyzers. Associations of WBC, Hb and other red blood cell markers with cardiometabolic risk factors and physical activity were examined by Pearson’s partial correlation coefficient test and with linear mixed regression models. Results: In sex- and age-adjusted correlation analyses both BMI and waist circumference correlated positively with Hb, WBC, red blood cell count (RBC), and hematocrit. Hb was also positively correlated with systolic blood pressure, insulin resistance scores, liver enzymes, LDL, and triglyceride levels. Sedentary time correlated positively with WBC, whereas standing time correlated negatively with WBC. Lying time correlated positively with WBC, RBC, hematocrit, and Hb. Regarding SB and PA measures, only the association between lying time and RBC remained significant after adjustment for the BMI. Conclusion: We conclude that body adiposity, rather than components of SB or PA, associates with Hb levels and WBC, which cluster with general metabolic derangement.
Factors Associated with Discrepancy of Child-Adolescent/Parent Reported Quality of Life in the Era of COVID-19
Authors: Jeanbert Elodie , Baumann Cédric , Todorović Anja , Tarquinio Cyril , Rousseau Hélène , Bourion-Bédès Stéphanie
Published: November 2022

Billions of children/adolescents experienced unprecedented changes in their daily lives that impacted their health-related quality of life (HRQoL) during the first wave of the coronavirus disease 2019. The purpose of this study was to describe child-parent discrepancies in reporting on HRQoL and explore factors associated with such discrepancies at the end of the first lockdown in France. A cross-sectional study was conducted among French school-aged children from 8 to 18 years and their parents living in the Grand Est region in France during the first wave of the epidemic. The impact of individual, self-reported health status and environmental data on discrepant parent–child reports of HRQoL was assessed by multinomial multivariable logistic regression models. A total of 471 parent–child pairs were included. Among 50% of the discordant pairs, parents underestimated HRQoL more frequently than they overestimated it. Home location, social support score, children’s education level, parents’ education level, tensions and conflicts with neighbors reported by children, whether they had access to a garden, and parents’ professional activity were significantly associated with parental overestimation (adjustedOR from 2.08 to 11.61; p < 0.05). Factors associated with parental underestimation were children’s education level, SF12 score, home location, the child’s gender, parent’s level of education, the presence of noise in the residence reported by children, whether a household member was infected with COVID-19, whether they had access to a garden, and family structure (adjustedOR from 1.60 to 4.0; p < 0.05). This study revealed differences between child-reported and parent-reported HRQoL. The COVID-19 pandemic accentuated the discrepancies in observable dimensions and attenuated them in unobservable dimensions of HRQoL but did not impact the directional discrepancy; parents underestimated their child’s HRQoL more. These discrepancies appear to be explained by parent and child sociodemographic factors.
Effects of Mental Fatigue on Reaction Time in Sportsmen
Authors: Migliaccio Gian Mario , Di Filippo Gloria , Russo Luca , Orgiana Tania , Ardigò Luca Paolo , Casal Marcela Zimmermann , Peyré-Tartaruga Leonardo Alexandre , Padulo Johnny
Published: November 2022

Aim: Mental fatigue (MF) has been defined as a psychobiological state commonly caused by prolonged periods of demanding cognitive activity. However, the differences between women and men in their reaction times (RTs) to visual stimuli due to mental fatigue remain largely unknown. We compare the differences in RT and heart rate after an acute intervention of mental fatigue between male and female athletes. Materials and methods: For this aim, 64 participants (age 31.7 ± 6.2 y) performed a routine of 15 min of the Stroop test (PsyTool), with 600 tasks and five different colors. Their heart rate (HR) was registered before, during, and one, three, and five minutes after the Stroop test. Meanwhile, the RT was evaluated before and after the Stroop test. A general linear mixed model (GLMM) and a Bonferroni post hoc test were used to compare the HR between the conditions and an ANOVA two-way analysis was used to compare the values pre-/post-Stroop test. (α = 0.05). Results: The GLMM for HR showed an effect on the time (p < 0.001) and the time × group interaction (p = 0.004). The RT was significantly increased pre- to post-Stroop test (p < 0.05); however, there was no difference between the pre- and post-HR measurements (p = 1.000) and the measurements one (p = 0.559), three (p = 1.000) and five (p = 1.000) min after the Stroop test. Conclusion: The present findings suggest that the parasympathetic branch of the autonomous nervous system which functions as a relaxation system tends to be activated under increasing mental fatigue, with a decreased performance (RT) similarly in men and women. Therefore, athletes could use MF induced during training to improve the time delay related to motor tasks.
Impact of the COVID-19 Pandemic on the Incidence of Suicidal Behaviors: A Retrospective Analysis of Integrated Electronic Health Records in a Population of 7.5 Million
Authors: Valero-Bover Damià , Fradera Marc , Carot-Sans Gerard , Parra Isabel , Piera-Jiménez Jordi , Pontes Caridad , Palao Diego
Published: November 2022

The COVID-19 pandemic has caused remarkable psychological overwhelming and an increase in stressors that may trigger suicidal behaviors. However, its impact on the rate of suicidal behaviors has been poorly reported. We conducted a population-based retrospective analysis of all suicidal behaviors attended in healthcare centers of Catalonia (northeast Spain; 7.5 million inhabitants) between January 2017 and June 2022 (secondary use of data routinely reported to central suicide and diagnosis registries). We retrieved data from this period, including an assessment of suicide risk and individuals’ socioeconomic as well as clinical characteristics. Data were summarized yearly and for the periods before and after the onset of the COVID-19 pandemic in Spain in March 2020. The analysis included 26,458 episodes of suicidal behavior (21,920 individuals); of these, 16,414 (62.0%) were suicide attempts. The monthly moving average ranged between 300 and 400 episodes until July 2020, and progressively increased to over 600 episodes monthly. In the postpandemic period, suicidal ideation increased at the expense of suicidal attempts. Cases showed a lower suicide risk; the percentage of females and younger individuals increased, whereas the prevalence of classical risk factors, such as living alone, lacking a family network, and a history of psychiatric diagnosis, decreased. In summary, suicidal behaviors have increased during the COVID-19 pandemic, with more episodes of suicidal ideation without attempts in addition to younger and lower risk profiles.
Socioeconomic Deprivation, Sleep Duration, and Mental Health during the First Year of the COVID-19 Pandemic
Authors: Griggs Stephanie , Horvat Davey Christine , Howard Quiana , Pignatiello Grant , Duwadi Deepesh
Published: November 2022

The coronavirus disease 2019 (COVID-19) has had a rapid and sustained negative impact on sleep and mental health in the United States with disproportionate morbidity and mortality among socioeconomically deprived populations. We used multivariable and logistic regression to evaluate the associations among sleep duration, mental health, and socioeconomic deprivation (social deprivation index) in 14,676 Ohio residents from 1101 zip code tabulation areas from the 2020 Behavioral Risk Factor Surveillance System (BRFSS) survey. Higher socioeconomic deprivation was associated with shorter sleep and poorer mental health after adjusting for covariates (age, sex, race, education, income, and body mass index) in the multivariable linear regression models. Those in the highest socioeconomically deprived areas had 1.6 and 1.5 times higher odds of short sleep (duration < 6 h) and poor mental health (>14 poor mental health days), respectively, in the logistic regression models. Previous researchers have focused on limited socio-environmental factors such as crowding and income. We examined the role of a composite area based measure of socioeconomic deprivation in sleep duration and mental health during the first year of COVID-19. Our results suggest the need for a broader framework to understand the associations among socioeconomic deprivation, sleep duration, and mental health during a catastrophic event.
Psychometric Properties of the Spanish Version of the Work Group Emotional Intelligence Profile Short Version (WEIP-S) in a Sample of Spanish Federated Coaches
Authors: Granado-Peinado Miriam , Marchena-Giráldez Carlos , Martínez-Infiesta Inés , Acebes-Sánchez Jorge
Published: November 2022

Emotional intelligence has been a topic of great interest to researchers in many different areas as it is associated with mental, psychosomatic, and physical health. In the sports context, it is a significant variable that can play an important role in improving the team’s performance. Although there are numerous tools to assess emotional intelligence, few of them have been validated explicitly in a sports sample, and even fewer have had coaches as a target population. Therefore, this study aimed to validate the Spanish version of the work group emotional intelligence profile short version (WEIP-S) in a sample of Spanish federated coaches. The results confirm that this instrument presents good psychometric properties to measure the emotional intelligence of sports coaches. The original four-factor model (awareness of one’s own emotions, management of one’s own emotions, awareness of others’ emotions, and management of others’ emotions) shows good reliability and convergent validity for all four factors except for the management of one’s own emotions. These findings suggest that it is possible to measure the emotional intelligence of coaches and offer the opportunity to continue investigating the relevance of constructing specific scales to measure this construct in the sports context.
An Evaluation of Non-Communicable Diseases and Risk Factors Associated with COVID-19 Disease Severity in Dubai, United Arab Emirates: An Observational Retrospective Study
Authors: Al Bastaki Najwa Abdulwahed , Sheek-Hussein Mohamud , Shukla Ankita , Al-Bluwi Najlaa , Saddik Basema
Published: November 2022

The aim of this study was to determine the prevalence of non-communicable diseases and their correlation with COVID-19 disease severity among patients infected in Dubai. Clinical and demographic data were extracted from hospital records of 34,687 COVID-19 patients who visited or were admitted into Dubai hospitals between 28 January 2020 and 30 September 2020. Prevalence of co-morbidities in COVID-19 patients were assessed. The main risk factors associated with COVID-19 disease severity were also identified using three regression models. All co-morbidities were significantly associated with COVID-19 severity in the bivariate analysis (p-value ≤ 0.05) except for vitamin-D deficiency and chronic lower respiratory diseases. Patients with ischemic heart diseases (AOR: 2.08; 95% CI: 1.37, 3.15), pulmonary and other heart diseases (AOR: 2.13; 95% CI: 1.36, 3.32) and chronic kidney diseases (AOR: 1.81; 95% CI: 1.01, 3.25) had higher odds of severe COVID-19 symptoms. Suffering from multiple co-morbidities increased the odds of developing severe COVID-19 symptoms substantially in comparison to having only one co-morbidity i.e., (AOR: 1.52; 95% CI 1.76–2.60) to (AOR: 2.33; 95% CI: 1.37, 3.97). Identifying these risk factors could assist in the early recognition of high-risk populations and ensure the most appropriate preventive measures and required medical management during the pandemic.
Uncovering the Root Causes of Stall Flutter in a Wide Chord Fan Blisk
Authors: Huang Huang , Yang Mingming , Wang Dingxi
Published: November 2022

Flutter was encountered at part speeds in a scaled wide chord fan blisk designed for a civil aeroengine during a rig test when the fan bypass flow was throttled toward its stall boundary. Analysis of the blade tip timing measurement data revealed that the fan blades vibrated at the first flap (1F) mode with nodal diameters of two and three. To facilitate a further rig test and ultimately eliminate the flutter problem, a numerical campaign was launched to help understand the root causes of the flutter. Both the influence coefficient method (ICM) and the traveling wave method (TWM) were employed in the numerical investigation to analyze unsteady flows due to blade vibration, with the intention to corroborate different numerical results and take advantage of each method. To eliminate nonphysical reflections, a sponge layer with an inflated mesh size was used for the extended inlet and outlet regions. Steady flow field and unsteady flow field were examined to relate them to the blade flutter. The influences of vibration frequency, mass flow rate, shock, boundary layer separation and acoustic mode propagation behaviors on the fan flutter stability were also investigated. Particular attention was paid to the acoustic mode propagation behaviors.
New Aspects of the Synthesis of closo-Dodecaborate Nitrilium Derivatives [B12H11NCR]− (R = n-C3H7, i-C3H7, 4-C6H4CH3, 1-C10H7): Experimental and Theoretical Studies
Authors: Nelyubin Alexey V. , Klyukin Ilya N. , Novikov Alexander S. , Zhdanov Andrey P. , Selivanov Nikita A. , Bykov Alexander Yu. , Kubasov Alexey S. , Zhizhin Konstantin Yu. , Kuznetsov Nikolay T.
Published: November 2022

The preparation of novel nitrilium derivatives of closo-dodecaborate anion [B12H11NCR]−, R = n-C3H7, i-C3H7, 4-C6H4CH3, 1-C10H7 is described. Target compounds were obtained in good yields (up to 73%). The synthesis of target borylated nitrilium derivatives was characterised by the simplicity of the chemical apparatus and the absence of the necessity for the purification of desired compounds. The crystal structures of previously obtained [B12H11NCCH3]− and novel [B12H11NCC3H7]− were established with the help of X-ray structure analysis. DFT-analysis of several nitrilium derivatives [B12H11NCR]−, R = CH3, C3H7, 4-CH3C6H4 was carried out. The main peculiarities of the C≡N bond of the exo-polyhedral substituent were revealed in terms of bond lengths, bond orders and atomic charges. The LUMO orbitals of the systems considered were examined for understanding of the electrophilic nature of the nitrilium derivatives of the closo-dodecaborate anion.
Psyttala horrida (Stål, 1865) (Hemiptera: Reduviidae: Reduviinae)—A Morphological Study of Eggs and Nymphs
Authors: Bugaj-Nawrocka Agnieszka , Danielczyk Agata , Sułkowska Iga , Chłond Dominik
Published: November 2022

In terms of body size, species of the genus Psyttala Stål, 1859, are the largest known representatives of the subfamily Reduviinae. Among the species belonging to this genus, Psyttala horrida (Stål, 1865) is the most popular, mainly because it is a laboratory breeding species. Individuals of this species were bred in the laboratory of the Zoology Team at the University of Silesia in Katowice, Poland. A description of the morphology of the nymphs and eggs is presented. In addition to descriptions, photos of the successive immature stages are provided and scanning electron microscopy (SEM) images are included to show morphological details and compare the developmental changes in subsequent stages.
Three-Dimensional Electro-Anatomical Mapping and Myocardial Work Performance during Spontaneous Rhythm, His Bundle Pacing and Right Ventricular Pacing: The EMPATHY Study
Authors: Malagù Michele , Vitali Francesco , Massafra Rodolfo Francesco , Cardelli Laura Sofia , Pavasini Rita , Guardigli Gabriele , Rapezzi Claudio , Bertini Matteo
Published: November 2022

Background. His bundle pacing (HBP) has emerged as an alternative site to right ventricular pacing (RVP) with encouraging outcomes. To date, no study has investigated the systematic approach of three-dimensional electroanatomic mapping (3D-EAM) to guide HBP implantation and to evaluate myocardial activation timing. Furthermore, studies reporting a comprehensive assessment of the ventricular function, using myocardial work (MW) evaluation are lacking. Objectives. (1) To evaluate the systematic use of the 3D-EAM as a guide to HBP; (2) to assess the electrical and mechanical activations with high-density mapping, comparing spontaneous ventricular activation (SVA), HBP and RVP; (3) to assess the myocardial function through speckle-tracking echocardiography (STE) and MW analysis in SVA, HBP and RVP. Methods. 3D-EAM was performed in consecutive patients undergoing HBP implantation with a low use of fluoroscopy. All patients were systematically evaluated with high-density mapping, MW and STE. Results. Fifteen patients were enrolled, of whom three had an implant failure (20%). RV activation time was not statistically different between SVA and HBP (103 vs. 104 ms, p = 0.969) but was significantly higher in RVP (133 ms, p = 0.011 vs. SVA and p = 0.001 vs HBP). Global constructive work was significantly lower during RVP (1191 mmHg%) than during SVA and HBP (1648 and 1505 mmHg%, p = 0.011 and p = 0.008, respectively) and did not differ between SVA and HBP (p = 0.075). Conclusions. 3D-EAM and MW evaluation showed that HBP was comparable to the physiological SVA in terms of activation time and cardiac performance. Compared to both SVA and HBP, RVP was associated with a worse activation timing and ventricular efficiency.
Minimum 10-Year Results of Modular Metal-On-Metal Total Hip Arthroplasty
Authors: Wakabayashi Hiroki , Hasegawa Masahiro , Naito Yohei , Tone Shine , Sudo Akihiro
Published: November 2022

Background: this study aimed to assess the long-term outcomes of (a minimum of 10-years) total hip arthroplasty with a metal-on-metal acetabular prosthesis. Methods: Eighty-nine primary total hip arthroplasties (82 patients) were performed using a Pinnacle modular metal-on-metal acetabular prosthesis. Clinical hip function outcomes were evaluated using the Japanese Orthopaedic Association hip score preoperatively and at the final follow-up. Radiological analysis was performed at the final follow-up and magnetic resonance imaging in all hips postoperatively. Results: Out of 82 patients, 17 were excluded who were followed up for <10 years. Of the remaining 65 patients (70 hips), 19 (20 hips) developed pseudotumors during 2–10 years postoperatively. After 10 and 13 years, the survival rates of revision endpoint were 93.6% and 90.4%, respectively. Clinical hip function outcomes had improved significantly at the final follow-up. In the radiological analysis, the mean cup angle of inclination and mean ratio of femoral offset on the operated hip to the contralateral hip was highest in patients with revision surgery for adverse reactions to metal debris. Conclusions: This study showed a 29.0% prevalence of pseudotumors. Some cases required revisions even after 10 years following surgery. Regular clinical surveillance is recommended for the early detection of adverse reactions to metal debris.
Effects of Different Endometrial Preparation Regimens during IVF on Incidence of Ischemic Placental Disease for FET Cycles
Authors: Wang Yingjie , Chen Qiuju , Wang Yun
Published: November 2022

We conducted this retrospective cohort study aiming to compare the different pregnancy outcomes of endometrial preparation regimens on ischemic placental disease in a frozen embryo transfer cycle. The study included a total of 9351 women who had undergone therapy at our single tertiary hospital from January 2015 to July 2020. The women were divided into three groups depending on their endometrial regimens: natural cycle, stimulation cycle, hormone replacement therapy cycle. The data were analyzed after propensity score matching, then we used multiple linear regression to study the relationship between ischemic placental disease and endometrial regimens, adjusted by confounding factors including age, body mass index, and score of propensity score matching. We performed univariate logistic regression, as well as multivariate logistic regression for ischemic placental disease, small for gestational age infant, placental abruption. and pre-eclampsia, respectively, listing the odds ratio and p-values in the table. As a result, risk of ischemic placental disease and small for gestational age infant were detected as higher in stimulation cycles compared to natural cycles before or after adjustment. Hormone replacement therapy cycles conferred a higher risk of pre-eclampsia and preterm delivery compared to natural cycles. No difference was found between stimulation cycles and hormone replacement therapy cycles, regardless of whether they are adjusted or not. In summary, more pharmacological intervention in endometrial preparation was associated with a higher risk of ischemic placental disease related symptoms than natural cycles for endometrial preparation in women undergoing frozen embryo transfer. Our findings supported that minimizing pharmacological interventions during endometrial preparation when conditions permit has positive implications for improving pregnancy outcomes.
Long-Term Follow-Up after Testicular Torsion: Prospective Evaluation of Endocrine and Exocrine Testicular Function, Fertility, Oxidative Stress and Erectile Function
Authors: Törzsök Peter , Steiner Christopher , Pallauf Maximilian , Abenhardt Michael , Milinovic Ljiljana , Plank Bethseba , Rückl Alena , Sieberer Manuela , Lusuardi Lukas , Deininger Susanne
Published: November 2022

Background: This study investigates endocrine and exocrine testicular function, oxidative stress (OS) in semen, and erectile function in patients who underwent surgery for suspected testicular torsion (TT). Methods: We evaluated 49 patients over a mean follow-up of 101 months: n = 25 patients treated with surgical exploration, n = 20 patients treated with detorsion, and n = 4 treated with orchiectomy. We performed semen analysis including Male infertility Oxidative System (MyOxSIS) analysis, physical examination, and evaluation of endocrine and erectile function. Results: OS, erectile function and spermiogram categories did not differ significantly between the groups. The interval from the onset of symptoms to surgery differed significantly between groups (p < 0.001). Preservation of the testes was associated with a higher round cell count (p = 0.002) and follicle stimulating hormone (FSH, p = 0.003). OS showed a significant positive correlation with the spermiogram category (0.337; p = 0.022). A negative correlation was observed between OS and age (p = 0.033), sperm concentration (p < 0.001) and total sperm count (p = 0.006). Conclusions: Endocrine, exocrine and erectile function are not significantly affected by TT in the long term. Orchiectomy results in elevated FSH and a lower round cell count compared to preservation of the testis.
The Efficacy of Cervical Lordosis Rehabilitation for Nerve Root Function and Pain in Cervical Spondylotic Radiculopathy: A Randomized Trial with 2-Year Follow-Up
Authors: Moustafa Ibrahim M. , Diab Aliaa A. , Harrison Deed E.
Published: November 2022

Sagittal cervical alignment is a clinically related feature in patients suffering from chronic cervical spondylotic radiculopathy (CSR). We designed this randomized trial to explore the effects of cervical lordosis (CL) correction in thirty chronic lower CSR patients with CL < 20°. Patients were assigned randomly into two equal groups, study (SG) and control (CG). Both groups received neck stretching and exercises and infrared radiation; additionally, the SG received cervical extension traction. Treatments were applied 3× per week for 10 weeks after which groups were followed for 3 months and 2 years. The amplitude of dermatomal somatosensory evoked potentials (DSSEPS), CL C2–C7, and pain scales (NRS) were measured. The SG had an increase in CL post-treatment (p < 0.0001), this was maintained at 3 months and 2 years. No statistical improvement in CL was found for the CG. A significant reduction in NRS for SG after 10 weeks of treatment with non-significant loss of change at 3 months and continued improvement at 2 years was found. CG had less significant improvement in post-treatment NRS; the 3-month and 2-year measures revealed significant worsening in NRS. An inverse linear correlation between increased CL and NRS was found (r = −0.49; p = 0.005) for both groups initially and maintained in SG at the final 2-year follow-up (r = −0.6; p = 0.01). At 10 weeks, we found significant improvements in DSSEPS for both groups (p < 0.0001). We identified a linear correlation between initial DSSEPs and CL for both groups (p < 0.0001), maintained only in the SG at the final follow-up for all levels (p < 0.0001). Improved CL in the SG correlated with significant improvements in nerve root function and pain rating in patients with CSR at short and long-term follow-up. These observed effects indicate that clinicians involved in the treatment of patients with symptoms of cervical degenerative disorders should add sagittal curve correction to their armamentarium of rehabilitation procedures for relevant patient populations.
Identification of Early Clinical and Histological Factors Predictive of Kasai Portoenterostomy Failure
Authors: Lemoine Caroline P. , Melin-Aldana Hector , Brandt Katherine A. , Superina Riccardo
Published: November 2022

Background: It is impossible to predict which patients with biliary atresia (BA) will fail after Kasai portoenterostomy (KPE). We evaluated the predictive nature of pre-KPE clinical and histological factors on transplant-free survival (TFS) and jaundice clearance. Methods: A retrospective review of patients who received a KPE at our institution (1997–2018) was performed. Primary outcomes were two-year TFS, five-year TFS, and jaundice clearance 3 months after KPE. p < 0.05 was considered significant. Results: Fifty-four patients were included in this study. The two-year TFS was 35.1%, five-year TFS was 24.5%, and 37% patients reached a direct bilirubin (DB) ≤ 2.0 mg/dL 3 months post KPE. The median age at biopsy was younger in the five-year TFS (39.0 (24.5–55.5) vs. 56.0 days (51.0–67.0), p = 0.011). Patients with DB ≤ 1.0 mg/dL 3 months after KPE were statistically younger at biopsy (DB ≤ 1.0 44.0 (26.0–56.0) vs. DB > 1.0 56.0 days (51.0–69.0), p = 0.016). Ductal plate malformation was less frequent in the five-year TFS (16/17, 94.1%, vs. 1/17, 5.9%, p = 0.037). Portal fibrosis (19/23, 82.6%, vs. 4/23, 17.4%, p = 0.028) and acute cholangitis (6/7, 85.7%, vs. 1/7, 14.3%, p = 0.047) occurred less frequently in two-year TFS. Conclusion: Older age at biopsy, acute cholangitis, portal fibrosis, and ductal plate malformation were associated with lower native liver survival. Evaluation in a larger study population is needed to validate these results.
Numerical Simulation of Two-Phase Flow in Liquid Composite Moulding Using VOF-Based Implicit Time-Stepping Scheme
Authors: Alotaibi Hatim , Abeykoon Chamil , Soutis Constantinos , Jabbari Masoud
Published: November 2022

The filling stage in injection/infusion moulding processes plays a key role in composite manufacturing that can be influenced by the inlet and vent ports. This will affect the production of void-free parts and the desirable process time. Flow control is usually required in experiments to optimise such a stage; however, numerical simulations can be alternatively used to predict manufacturing-induced deficiencies and potentially remove them in the actual experiments. This study uses ANSYS Fluent software to model flow-front advancement during the impregnation of woven fabrics. A developed technique is applied by creating tracking points (e.g., on-line monitor) in the direction of the flow to report/collect data for flow-front positions as a function of time. The study adopts the FVM-VOF-based two-phase flow model together with an implicit time-stepping scheme, i.e., a dual-time formulation solution method with a preconditioned pseudo-time derivative. Initially, three time-step sizes, 5 s (small), 25 s, and 50 s (large), are evaluated to examine their impact on numerical saturation lines at various fabric porosities, 40%, 50%, and 60%, for a two-dimensional (2D) rectangular mould, and predictions are then compared with the well-known analytical Darcy. This is followed by a three-dimensional (3D) curved mould for a fillet L-shaped structure, wherein the degree-of-curvature of fibre preforms is incorporated using a User-Defined Function (UDF) to tailor the impregnation process. The developed approach shows its validation (1–5.7%) with theoretical calculations and experimental data for 2D and 3D cases, respectively. The results also stress that a shorter computational time can be achieved with a large time-step size while maintaining the same level of accuracy.
3D Bioprinting Technology and Hydrogels Used in the Process
Authors: Lima Tainara de P. L. , Canelas Caio Augusto d. A. , Concha Viktor O. C. , Costa Fernando A. M. da , Passos Marcele F.
Published: November 2022

3D bioprinting has gained visibility in regenerative medicine and tissue engineering due to its applicability. Over time, this technology has been optimized and adapted to ensure a better printability of bioinks and biomaterial inks, contributing to developing structures that mimic human anatomy. Therefore, cross-linked polymeric materials, such as hydrogels, have been highly targeted for the elaboration of bioinks, as they guarantee cell proliferation and adhesion. Thus, this short review offers a brief evolution of the 3D bioprinting technology and elucidates the main hydrogels used in the process.
Putamen Atrophy Is a Possible Clinical Evaluation Index for Parkinson’s Disease Using Human Brain Magnetic Resonance Imaging
Authors: Kinoshita Keisuke , Kuge Takehito , Hara Yoshie , Mekata Kojiro
Published: November 2022

Parkinson’s disease is characterized by motor dysfunction caused by functional deterioration of the substantia nigra. Lower putamen volume (i.e., putamen atrophy) may be an important clinical indicator of motor dysfunction and neurological symptoms, such as autonomic dysfunction, in patients with Parkinson’s disease. We proposed and applied a new evaluation method for putamen volume measurement on 31 high-resolution T2-weighted magnetic resonance images from 16 patients with Parkinson’s disease (age, 80.3 ± 7.30 years; seven men, nine women) and 30 such images from 19 control participants (age, 75.1 ± 7.85 years; eleven men, eight women). Putamen atrophy was expressed using a ratio based on the thalamus. The obtained values were used to assess differences between the groups using the Wilcoxon rank-sum test. The intraclass correlation coefficient showed sufficient intra-rater reliability and validity of this method. The Parkinson’s disease group had a significantly lower mean change ratio in the putamen (0.633) than the control group (0.719), suggesting that putamen atrophy may be identified using two-dimensional images. The evaluation method presented in this study may indicate the appearance of motor dysfunction and cognitive decline and could serve as a clinical evaluation index for Parkinson’s disease.
Adenosquamous Carcinomas and Mucinous Adenocarcinoma of the Minor Salivary Glands: Immunohistochemical and Molecular Insights
Authors: Khalele Bacem , Laforga Juan B. , Kajo Karol , Kajová Macháleková Katarína
Published: November 2022

There is confusion about the diagnosis, histogenesis and taxonomical efforts regarding adenosquamous carcinomas (ASCs) and mucinous adenocarcinomas (MACs), especially with calls for reconsidering the nature of high-grade mucoepidermoid carcinoma (MEC). This study aims to compare the genetic profiles of ASCs and MACs that have been previously reported in the literature and investigate if either ASC or MAC is closer in genetic mutations to high-grade MEC. Systematic searches in the NCBI, Web of Science, and Scopus databases were performed between January 2000 and August 2022. The retrieved genetic mutations were processed and annotated. Protein–protein network analysis was conducted for each neoplasm. The results were viewed and discussed in terms of molecular oncogenesis of ASCs and MACs at different topographies. Molecular profile mapping was conducted by annotating all the retrieved genes for each neoplasm using genetic network analysis (Cystoscape software program). The genetic profile of each lesion was compared to that of high-grade MEC. To conclude, both genetic profiles do not tend to intersect specifically with high-grade MEC, except for the generic mutations commonly detected in all high-grade head and neck tumors. However, the availability of data on the molecular profile of each lesion limits the generalizability of the findings of this study.
Ecological Risk Assessment of Heavy Metals and Environmental Quality of Tunisian Harbours
Authors: Rebai Nourhene , Mosbahi Nawfel , Dauvin Jean-Claude , Neifar Lassad
Published: November 2022

Harbours are one of the most disturbed coastal ecosystems due to intensive anthropogenic pressures. This study aimed for the first time to compare anthropogenic impacts in three harbours from the central coast of Tunisia (Mediterranean Sea) employing analysis of heavy metal contamination and ecological quality status (EcoQS). Sampling was carried out in spring 2019 in the fishing harbour of Teboulba, the marina of Monastir, and the commercial harbour of Sousse. The high levels of concentration in heavy metals and organic matter were closely related to the fine-grained fraction of the sediment in the fishing and commercial harbours. A total of 94 macrobenthic species, including five nonindigenous species, were identified belonging to six zoological groups. Multivariate analyses highlighted a strong influence of the harbour activity on the diversity of macrozoobenthic communities. Three benthic assemblages were identified according to their environmental characteristics such as sediment type, organic matter content, and heavy metal contamination. Benthic and biotic indices (H′, J′, AMBI, and BO2A) showed that the EcoQS varied from poor (commercial harbour) to good (marina), and was significantly influenced by harbour activity, organic matter, and heavy metal contamination of the sediment. The present work could be considered as providing important baseline data for the implementation of national environmental policies and management plans in the future.
Time Domain Nonlinear Dynamic Response Analysis of Offshore Wind Turbines on Gravity Base Foundation under Wind and Wave Loads
Authors: Tu Wenbo , He Yufan , Liu Linya , Liu Zonghui , Zhang Xiaolei , Ke Wenhai
Published: November 2022

The third-generation gravity base foundation, which consists of a concrete-based structure with infill aggregates, is designed for water depths greater than 20 m. In this study, a simplified method in the time domain for predicting the nonlinear dynamic response of the offshore wind turbine supported on the third-generation gravity base foundation is proposed. The results obtained by the proposed method are compared with 3D finite element simulations, and the consistency of the results verifies the reliability of the simplified method. In addition, the dynamic response of the wind turbine supported on GBF under wind and wave loads is investigated. The results indicate that the lateral dynamic responses of the GBF are more affected by the thrust force than by the distributed force when the wind loads are only considered; the maximum dynamic displacement of the GBF caused by the drag force is almost the same as that of the GBF caused by the inertia force when the wave loads are only considered, and the dynamic response of the GBF under combined wind and wave loads show a similar trend to that of the GBF under the wind loads only, especially the existence of a large displacement on the horizontal direction at the beginning of the loading.
Development of a Portable Interface System Sharing the Positioning and Heading Information to Support a Berthing Vessel
Authors: Ito Kazuki , Tsuyuzaki Toyoharu , Yuasa Daiki , Choi Yongwoon , Kim Young-Bok
Published: November 2022

The study develops a portable interface system to inform berthing operators of the position and heading in relation to the quay when berthing a large vessel equipped with distance-measuring instruments. A portable interface system is indispensable for preventing collisions and improving the efficiency of berthing operations because it allows operators to intuitively grasp the movement status of the vessel based on the distance data measured during berthing. These data can not only be converted into the current position and heading of the vessel relative to the quay, but can also be visualized to predict the movement and speed of the vessel in a few seconds. Therefore, we developed a visualization system using Rviz, a 3D model visualization tool for a robot operating system, and verified the necessity for an interface system through simulations and experiments using a model vessel. Furthermore, we extended the function of the visualization interface using a wireless network, developed a web application to display the vessel’s positioning information on multiple operators’ terminals, and verified the drawing stability at 10 Hz using the extended application.
Fungal Pathogens Associated with Strawberry Crown Rot Disease in China
Authors: Zhang Yanting , Yu Hong , Hu Meihua , Wu Jianyan , Zhang Chuanqing
Published: November 2022

Strawberry crown rot (SCR) is a serious disease that is generally referred to as seedling anthracnose due to its association with Colletotrichum spp. Presently, SCR is the main cause of death of strawberry seedlings. However, management strategies, including fungicides targeting Colletotrichum spp., have failed to obtain satisfactory results. Therefore, identifying the exact pathogen species causing SCR could guide its management. A total of 287 isolates were obtained from SCR-diseased plants. Based on the culture, morphology, and phylogenetic characteristics, the above 287 fungal isolates of SCR pathogens were identified as 12 different species, including Colletotrichum siamense, C. fructicola, Fusarium oxysporum, F. commune, F. equiseti, F. solani, F. tricinctum, Epicoccum sorghinum, Stemphylium lycopersici, Clonostachys rosea, Phoma herbarum, and Curvularia trifolii. Pathogenicity results showed that most isolates were pathogenic to strawberry seedlings and exhibited different degrees of virulence. In severe cases, poor growth on the ground, yellowing of the leaves, and even death of seedlings occurred. In mild cases, only black disease spots appeared on the stems of the strawberry seedlings, and a few withered leaves became necrotic. The inoculation experiments showed that the most virulent species were C. siamense and F. oxysporum, followed by F. equiseti, P. herbarum, Cl. rosea, S. lycopersici, and C. fructicola, which had disease incidences above 50%. E. sorghinum, S. lycopersici, Cl. rosea, P. herbarum and Cu. trifolii were reported to cause SCR for the first time herein. In conclusion, SCR is a sophisticated disease caused by a diversity of pathogenic fungi. This work provides new valuable data about the diversity and pathogenicity of SCR pathogens, which will help in formulating effective strategies to better control of the SCR disease.
Morphological and Transcriptional Characteristics of the Symbiotic Interaction between Pinus massoniana and Suillus bovinus
Authors: Feng Wanyan , Sun Xueguang , Ding Guijie
Published: November 2022

Ectomycorrhiza (ECM) function has been well studied; however, there is little detailed information regarding the establishment of ECM symbioses. We investigated the morphological and transcriptional changes that occur during the establishment of the Pinus massoniana–Suillus bovinus ECM. S. bovinus promoted the growth of P. massoniana via the release of volatile organic compounds and exudates during the pre-symbiotic stage. Exudate-induced effects showed host plant specificity. At seven days post-inoculation (dpi), the mycelium started to penetrate P. massoniana roots. At 28 dpi, the Hartig net and mantle formed. At the pre-symbiotic stage, most differentially expressed genes in P. massoniana roots were mapped to the biosynthesis of secondary metabolites, signal transduction, and carbohydrate metabolism. At the symbiotic stage, S. bovinus colonization induced the reprogramming of pathways involved in genetic information processing in P. massoniana, particularly at the Hartig net and mantle formation stage. Phenylpropanoid biosynthesis was present at all stages and was regulated via S. bovinus colonization. Enzyme inhibitor tests suggested that hydroxycinnamoyl-CoA shikimate/quinate transferase is involved in the development of the Hartig net. Our findings outline the mechanism involved in the P. massoniana–S. bovinus ECM. Further studies are needed to clarify the role of phenylpropanoid biosynthesis in ECM formation.
Institutional Motivations for Conversion from Public Sector Unit to a Social Business: The Case Study of Burgundy School of Business in France
Authors: Ashta Arvind
Published: November 2022

Based on a qualitative single case study with eight interviews, this study lays the foundation for literature on the motivation for transforming from a quasi-governmental entity to a social business. The context of this case study is a spin off of business schools from the French chambers of commerce and industry. This spin off was encouraged by enabling legislation that allowed assets specific to business schools to be transferred without taxes and fees if they adopted this legal business form. This case study is on the Burgundy School of Business, one of the seven schools that have adopted the regime. The school is also a member of the Principles of Responsible Management in Education. This case study suggests that the motivation for adopting a social business form could be institutional rather than personal. International rankings influence country legislation and business form adoption in a competitive industry. This case also discusses why the school has intentionally decided not to go for a digital transformation of its core business model. This case leads to theoretical propositions that consider the conditions under which public sector enterprises may spin off units as social businesses focused on their beneficiaries, and the control mechanisms that need to be instituted by the parent enterprise.
Renal Rehabilitation—Its Theory and Clinical Application to Patients Undergoing Daily Dialysis Therapy
Authors: Matsuzawa Ryota , Kakita Daisuke
Published: November 2022

An aging population and the prevalence of lifestyle-related ailments have led to a worldwide increase in the rate of chronic kidney disease requiring renal replacement therapy. The mean age of people requiring dialysis has been rising, and Japanese patients are aging more rapidly than those in the United States and Europe. Compared to people with normal kidney function, those undergoing hemodialysis are at increased risk of sarcopenia or frailty and serious health problems that limit access to kidney transplantation and lead to adverse health outcomes such as functional dependence, hospitalization, and death in patients on dialysis treatment. The Japanese Society of Renal Rehabilitation, established in 2011, published a clinical practice guideline for renal rehabilitation in 2019. Although the concept has become widely known among kidney health providers in recent years, efforts have still not focused on routine clinical care for patients with chronic kidney disease. In this review, the theory and clinical application of renal rehabilitation for patients undergoing daily hemodialysis were investigated.
Aging-in-Place and Home Modifications for Urban Regeneration
Authors: Qian Queena K. , Ho Winky K. O. , Jayantha Wadu M. , Chan Edwin H. W. , Xu Ying
Published: November 2022

The rapidly growing aging population is a global phenomenon imposing societal challenges on many cities. ‘Aging-in-place’ as a popular concept accommodates both the elderly desire to age in a familiar environment and adaptive old home modifications for aging. However, this concept has not been explored in-depth systematically in the urban regeneration context. This article explores a form of aging-in-place that is suitable for large and dense residential urban areas using the case of Hong Kong as an example of a laisse-faire fast-growing dense city, with a focus on home modifications. As in many other Asian cities, with a low tax rate and without a pension scheme, the elderly in Hong Kong are concerned more with the basic needs of health care and rely on public housing. Housing affordability is the primary concern. The government is expected to take the lead in aging-in-place in urban regeneration, in particular, to provide necessary home modifications for the elderly who live in public housing with primary health care provisions. A survey of 294 respondents revealed that housing expenditures, housing size, income level, and residential location are indicators of whether home modifications or health care in cities such as Hong Kong can be afforded by the locals, under tight budget constraints.