bluuebunny/crossref_metadata_2025 huggingface dataset:
E-Banking: Consumer Perception Towards Digital Banking With Reference to Standard Bank Ltd
Authors: Rahman SK Musfiqur
Published: April 2024

The banking industry's rapid digitalization, epitomized by the surge in electronic banking or e-banking, has reshaped consumer behaviors globally. In Bangladesh, a pivotal player in this transformation, understanding consumer perceptions towards digital banking, particularly with institutions like Standard Bank Ltd, holds immense significance. This study aims to unravel the complex tapestry of consumer attitudes and behaviors towards e-banking services provided by Standard Bank Ltd.

Using a quantitative research approach, structured surveys will be deployed to dissect various facets of consumer engagement with digital banking. The study will scrutinize levels of awareness, frequency of usage, satisfaction levels, perceived benefits, and risks associated with Standard Bank Ltd's e-banking platforms. Additionally, it seeks to identify factors influencing consumers' adoption of digital banking services and explore the interplay between perceived benefits, risks, and consumer behavior. Insights gleaned from this research are poised to provide invaluable guidance for Standard Bank Ltd and other banking institutions. By understanding consumers' evolving needs and expectations, tailored digital banking offerings can be crafted to enhance customer satisfaction and experience. Moreover, the study's findings will inform strategic decision-making processes and drive initiatives aimed at optimizing customer engagement strategies. In summary, this study contributes to the evolving discourse on e-banking and consumer behavior. It paints a nuanced portrait of consumer perceptions towards digital banking services in Bangladesh, with Standard Bank Ltd serving as a focal point for exploration. Through empirical analysis and insights, it charts a course toward a more customer-centric approach in the realm of digital banking.
Staunch the Age Related Decline into Dementia, Cancer, Autoimmunity (Long Covid), Obesity, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play
Authors: Chambers Patrick
Published: April 2024

“All diseases originate in the gut.” Hippocrates (400 BC)

A healthy gut microbiome via the gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. A dysbiotic gut microbiome, low in biodiversity and butyrate producers, can alter tryptophan metabolism (ATM) and increase the kynurenine to tryptophan ratio (KTR) with release of proinflammatory cytokines, predominantly TNF-α, IL-6, and IL-1β. These also characterize chronic inflammation, oxidative stress, and a multitude of diseases. Also proposed is the gut-lung dysbiosis concept and consequent degradation of ACE2 (richest in lungs and gut). Leaky gut (and lung) induced autoantibodies (AAs) related to G-protein coupled receptors (GPCRs) in combination with increased Ang II further potentiate oxidative stress. The underappreciated pathogenic role of Candida is explored. The efficacy of fecal microbiome transplantation (FMT) in treating dementia, cancer, and autoimmunity supports the plausibility of success with “FMT-lite”. This triple play of prebiotic (d-mannose), probiotic (bifidobacteria and lactobacilli), and postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry of GPCR antigens, suppress the inflammatory cytokine triad, balance IFN-γ and TGF-β, suppress oxidative stress, depress KTR, elevate HRV, and extend lifespan and its quality.
Global overview of monkeypox: An epidemiological and clinical update
Authors: Prado-Molina Diego Gerardo , Serna Trejos Juan Santiago , Bermúdez–Moyano Stefanya Geraldine , Rojas-Hernández Juan Pablo
Published: April 2024

Mpox (viruela símica) es una enfermedad viral que puede producir síntomas como erupción cutánea, adenomegalias y fiebre. Pese a su baja tasa de mortalidad, se relaciona con complicaciones que pueden comprometer la calidad de vida de las personas. Fue identificada por primera vez en humanos en 1970, desde entonces se mantenía una distribución geográfica y una incidencia controladas. No obstante, desde el año 2022 su incidencia ha aumentado al igual que su distribución geográfica alcanzando un total de 89.596 casos confirmados por laboratorio y 663 casos probables, incluidas 157 muertes, reportados al 28 de agosto de 2023; llegando incluso a países no endémicos. A continuación, se presenta una revisión narrativa con base en información recolectada en bases de datos como UpToDate, Google Scholar, Medline, ClinicalKey, Scopus, Embase, Pubmed; con el objetivo de describir los aspectos más relevantes de Mpox en humanos desde una perspectiva epidemiológica actual, además de presentar datos fisiopatológicos, de diagnóstico, tratamiento, pronóstico y rehabilitación.
Clinical characteristics and response to therapeutic plasma exchange in patients diagnosed with Guillain Barré syndrome in a third level clinic in the city of Cali - Colombia during the years 2016-2022.
Authors: Prado- Molina Diego Gerardo , Agudelo-Quintero Esteban , Cárdenas-Prieto José Mauricio , Serna Trejos Juan Santiago , Bermúdez – Moyano Stefanya Geraldine , Luis Felipe Cortez-Sanabria Luis Felipe , Caceres-Campo Catherine
Published: April 2024

Introduction: Guillain Barré syndrome (GBS) presents a non-negligible incidence rate in low-income countries. Intravenous human immunoglobulin (IVIG) and therapeutic plasma exchange (TPR) are the first-line treatments. Aim: The aim of this work is to describe the clinical characteristics and the response to RPT in patients with GBS. Materials and methods: Observational, descriptive, cross-sectional study with analytical scope of patients diagnosed with GBS who were managed with RPT, in two service-providing institutions (IPS) in the city of Cali-Colombia, between 2016 and 2022. outcomes: 33 patients with a mean age of 57+/-16 years were included. After a median stay of 10 days in the intensive care unit (ICU), 75.5% decreased at least one grade on the Hughes scale, 12.1% required mechanical ventilation (MV), 27.3% presented some complication, and there were no fatal outcomes. Prolonged stay in the ICU was significantly associated with an unfavorable clinical evolution. Conclusion: The results suggest that RPT management in an institution with highly complex standards, with early diagnosis and early medical intervention, can contribute to an adequate clinical evolution. Prolonged time in the intensive care unit (ICU) is a prognostic factor to consider in the clinical evolution of these patients. Studies with an analytical design and a larger sample are required to support these findings.
Die Klimakrise als universelle Kinderrechtsgefährdung
Authors: Schramkowski Barbara , Stamm Ingo
Published: April 2024

Im Fokus des Beitrags steht die Gefährdung der Kinderrechte durch Klimakrise, Artensterben und Naturzerstörung. Es wird der Frage nachgegangen, ob infolge der immensen ökologischen Schäden von einer chronischen Kinderrechtsverletzung gesprochen werden kann, welche die Gefährdung des Kindeswohls einschließt. Weiter wird reflektiert, welche Institutionen für die Realisierung sogenannter ökologischer Kinderrechte und die Abwendung der Gefährdungen verantwortlich sind und welche Aufgaben der Kinder- und Jugend­hilfe zukommen.
Gewaltpotentiale und Gewaltschutz in Privathaushalten mit 24-Stunden-Pflegekräften
Authors: Horn Vincent , Schweppe Cornelia
Published: April 2024

This contribution focusses a rarely addressed issue in research on home-based care in old age: violence and protection against violence in around-the-clock care arrangements in Germany. Based on a secondary analysis of data gained in the research project “Emergence and significance of transnational care arrangements (ESTRANCA)”, potential risk and protective factors are identified. The contribution shows that questions about violence and protection against violence in these arrangements have to be analysed in the context of complex, interrelated factors, structures and processes. No clear answers can be given whether these arrangements increase or decrease the risk of violence and neglect of older dependent people. Besides the ongoing tabooing of violence in home-based care in old age in general, the theming of violence in these particular arrangements is hampered by the common practice of employing around-the-clock migrant carers irregularly.
Bindungen zwischen Theorie und Praxis
Authors: Lubitz Ilona , Hartmann Ina
Published: April 2024

Bindungen stellen ein zentrales Kriterium in der Kinder- und Jugendhilfe (KJH) dar. Hierbei stellt sich die Frage inwiefern Sozialarbeiter*innen Erkenntnisse zur Bindungstheorie nutzen bzw. welche Wissensinhalte in der KJH vorhanden sind. Dies führt auch zu der Frage, inwieweit die verfügbare Literatur für die Praxis hilfreich ist, und wie der Wissensbestand von Sozialarbeiter*innen unterstützt werden kann. Es wurde deutlich, dass zwar alle Befragten die Relevanz von Bindungen in ihrem Arbeitsfeld bestätigten, gleichzeitig aber nur ein geringes Wissen über Bindungsmuster, -störungen oder -traumata hatten. Es zeigte sich weiterhin, dass zwar vielfältige Literatur zum Thema kindliche Bindungen vorhanden ist, diese jedoch nicht auf die Praxis von Sozialarbeiter*innen in der KJH ausgerichtet ist und keine einheitliche Darstellung von den o.g. Begrifflichkeiten bietet.
Cyber Honeypot
Authors: M. Sandhya Rani  , Guda Ankitha  , Polasani Harini  , G Ravi
Published: April 2024

In an era of escalating cyber threats, the need for robust defenses against malicious activities is paramount. In this project, we propose a novel approach to leverage honeypots in conju nction with Canary Tokens to accurately pinpoint the geographical locations of attackers. By strategically deploying these decoy resources across diverse network environments, we capture valuable data on unauthorized access attempts and malicious behavior. Through the analysis of Canary Tokens, which act as unique identifiers triggered upon interaction, we can trace the origin of these attacks to specific IP addresses. Utilizing this information, security professionals gain insights into the geographical distribution of attackers, aiding in threat intelligence, incident response, and the implementation of targeted security measures. This integration of project honeypots and Canary Tokens enhances network defense strategies, providing organizations with a proactive stance against cyber threats.
Analisis Pengaruh Tunjangan Kinerja (TUKIN) dan Pemanfaatan Tekhologi Informasi Terhadap Kinerja Individual Pegawai (Studi Kasus pada Pegawai IAIN Mataram yang Memperoleh Tukin)
Authors: Rosyidah Umu
Published: April 2024

Tunjangan kinerja diberikan kepada pegawai setiap bulan selain penghasilan yang berhak diterima menurut peraturan perundang-undangan, yang dihitung berdasarkan kehadiran kerja dan capaian kinerja individu sesuai dengan kelas jabatannya.
Using Behavioral Nudges and Incentives to Increase Affordability of Transit Systems through Donations
Authors: Kapatsila Bogdan , Grisé Emily
Published: April 2024

This study relies on an experimental design framework to identify the behavioral nudges and incentives that can facilitate altruism for a transportation-related cause of the members of a university community. Our findings reveal the overall willingness to support transportation options for low-income community members either through financial contributions or, in the case of some of the students, donating their infrequently used student transit passes. We also found the positive effect of recognition on donating for students and male car commuters, as well as higher chances for a sunk cost of a contribution to increase the likelihood of a donation.
Мовна ідеологія: соціолінгвістичний зміст концепту
Authors:   O. O. Potebnia Institute of Linguistics of the National Academy of Sciences of  Ukraine, AZHNIUK Bohdan
Published: April 2024

The article discusses the sociolinguistic concept of language ideology against the background of the international and Ukrainian research of the subject. Language ideology is usually treated a set of widely held beliefs about the language articulated by users as a rationalization or justification of perceived language structure and language practice. Language ideologies are not always clearly articulated and often include all kinds of assumptions about the nature of language and its use. Language ideology is shaped in the public discourse that involves a wide range of participants and it plays a significant role in the processes of language standardisation and in the formulation of language policy. Also discussed is the standard language ideology which refers to the belief that the variety that has its roots in the speech of the most powerful group in society is superior to other ways of speaking the language. Language ideology may be quite influential at the grassroots level and in the absence of formal law it can work as «policy with the manager left out». The article also addresses the issue of the structure of language ideology as a complex multidimensional construction consisting of a set of ideologemes. It is assumed that the influence of individual ideologemes may increase or go down, depending on a variety of socio-political, economical, demographic and other variables. Presumably language ideology has a core part and a periphery where new ideologemes are generated some of which gain influence and some decline. Top-down language ideology is determined by the government policy while bottom-up ideology is generated by the civil society institutions, scientific and academic community, language activists, the media etc. Ukrainian and international experience demonstrate that top-down and bottom-up language ideologies may alternate or combine simultaneously or at different times.
Мовно-інформаційний простір у контексті українського законодавства: соціолінгвістичні аспекти
Authors:   O. O. Potebnia Institute of Linguistics of the National Academy of Sciences of  Ukraine, MYKHALCHUK Oksana
Published: April 2024

The article focuses on the functioning of the language and information space as a marker of the state and on the choice of the language of information. The relationship between language and information is taking on new forms in the context of globalization and the intensive development of information dissemination. The information society is formed in the system of legislative, quantitative and qualitative dimensions of the language and information environment. The author outlines the prognostic prospects of the impact of the language and information space on the dynamics of the language situation, attitudes towards language and information security in general. A promising goal of the study is to determine the parameters of the language and information space as a sociolinguistic concept. The key issues of the relationship between language and information from the point of view of sociolinguistics are the choice of the language of information and the possibilities of this choice, the balance of the legislative and regulatory framework on language and information issues, and the orientation of language management in the information space. The variability of language-information relations in this context is traced in terms of national, community and individual information needs. Language-information relations in the parameters of language choice and the principles of current legislation are measured by sociolinguistic categories such as language power, language consciousness, communicative convenience, language rights, language strategies, etc. The spread and power of languages is usually related to their communicative and demographic characteristics. In the context of the study, we also talk about the information power of a language as an indicator of the language’s presence in the information space. The importance of the influence of language policy and language planning on the formation of the language and information space of the state is emphasized. Considerable attention is paid to the problems of choosing the language of information in the context of information security.
HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells
Authors: De Vos Tamara , Oatman Nicole , Boehme Lena , Putteman Tom , Velghe Imke , Van Droogenbroeck Yana , De Munter Stijn , Cesnekova Michaela , Van Nieuwerburgh Filip , Vandekerckhove Bart , Philippe Jan , Taghon Tom
Published: April 2024

Hematopoiesis is driven by molecular mechanisms that induce differentiation and proliferation of hematopoietic stem cells and their progeny. This involves the activity of various transcription factors, such as members of the Hairy/Enhancer of Split (HES) family, and important roles for both HES1 and HES4 have been shown in normal and malignant hematopoiesis. Here, we investigated the role of HES6 in human hematopoiesis using in vitro and in vivo models. Using bulk and scRNA-seq data, we show that HES6 is expressed during erythroid/megakaryocyte and pDC development, as well as in multipotent precursors and at specific stages of T- and B-cell development following preBCR and preTCR signalling, respectively. Consistently, knockdown of HES6 in cord blood-derived hematopoietic precursors in well-defined in vitro differentiation assays resulted in reduced differentiation of human hematopoietic precursors towards megakaryocytes, erythrocytes, pDCs, Band T-cells. In addition, HES6 knockdown HSPCs displayed reduced colony forming unit capacity in vitro and impaired potential to reconstitute hematopoiesis in vivo in a competitive transplantation assay. We demonstrate that loss of HES6 expression impacts cell cycle progression during erythroid differentiation and provide evidence for potential downstream target genes that impact these perturbations. Thus, our study uncovers new insights for a role of HES6 in human hematopoiesis.
Tantangan Transformasi Digital Bagi Kemajuan Perekonomian Indonesia
Authors: Aysa Imma Rokhmatul
Published: April 2024

Ekonomi digital saat ini terus berkembang di dunia tak terkecuali di Indonesia, hal ini ditandai dari meningkatnya pengguna internet. Awal tahun 2021 pengguna internet di Indonesia mencapai 202,6 juta jiwa meningkat 15,5 persen atau 27 juta jiwa jika dibandingkan pada Januari 2020. Terlebih saat  pandemi covid-19 telah merubah mekanisme pelayanan jasa dan perilaku konsumen. Para  pelaku usaha perlu berinovasi agar bagaimana bisa menyelaraskan kebiasaan baru para konsumen dari model jual beli konvensional menjadi e-commerce. Asosiasi Ecommerce Indonesia mencatat bahwa hingga Maret 2021 jumlah UMKM yang tergabung dalam berbagai marketplace telah mencapai kisaran 4,8 juta. Angka tersebut mengalami kenaikan dari akhir 2020 sebesar 3,8 juta. Namun ternyata kemajuan digitalisasi tak hanya mendatangkan keuntungan bagi pelaku usaha yang mampu berkembang dalam mengikuti kemajuan teknologi, namun juga menjadikan ketimpangan bagi yang tidak mampu mengikuti perkembangan digitalisasi. Penelitian ini adalah kajian pustaka dan hasil olah pikir peneliti. Jenis data yang digunakan adalah data sekunder dengan pendekatan kualitatif. Beberapa manfaat yang bisa kita peroleh dari digitalisasi bagi perkembangan perekonomian Indonesia diantanya pangsa pasar luas, transaksi lebih mudah, produksi meningkat, pembayaran lebih sederhana, dan promosi lebih variatif. Sedangkan sisi mudharat diantaranya kurangnya serapan tenaga kerja, rentan terjadi penipuan, dan plagiarisme. Selain itu sektor yang potensial berkembang di era digitalisai diantanya sektor keuangan, sektor pertanian, dan sektor kebudayaan, pariwisata, dan ekonomi kreatif.
Sistem Berbasis Web menggunakan Framework CodeIgniter untuk Pengelolaan Kurikulum SD Santa Patricia
Authors: Vionica Vionica , Wella Wella
Published: April 2024

Perubahan kurikulum didasarkan pada pemikiran tentang tantangan masa depan, yaitu tantangan abad kedua puluh satu, yang ditandai dengan abad ilmu pengetahuan, masyarakat berbasis pengetahuan, dan kemampuan masa depan. Sekolah Dasar Santa Patricia adalah salah satu sekolah yang menggunakan kurikulum 2013 saat ini. Perangkat lunak Microsoft Excel, dalam format yang sudah ada, masih digunakan oleh siswa di Sekolah Dasar Santa Patricia untuk mengolah nilai mereka. Pola penilaian rapor Kurikulum 2013 diketahui sangat kompleks, dan evaluasi yang menggunakan Microsoft Excel tidak optimal. Untuk mengatasi kekurangan yang ada, sistem penilaian akademik berbasis web dibangun berdasarkan alasan ini. Untuk membuat sistem ini, metode Extreme Programming (XP) digunakan karena dapat disesuaikan dengan kebutuhan sekolah. Selain itu, sistem ini dibangun menggunakan framework CodeIgniter, yang membantu developer membuat website yang lebih mudah digunakan. Hasil penelitian ini menghasilkan sistem penilaian akademik berbasis web, dan dari hasil pengujiannya, dapat disimpulkan bahwa sistem ini secara umum sangat disukai oleh pengguna.
Whatsapp to The Rescue: Automated Billing Reminders
Authors: Musyaffa Daffa Harastha , Desanti Ririn Ikana , Suryasari Suryasari
Published: April 2024

This research takes a case study approach to a company that provides digital marketing services. The company still relies on a manual process to record transactions on a spreadsheet. Their admin keeps track of clients' hosting and domain information in a Microsoft Excel file, and customers are not notified of their lease payment deadline in advance. There are also certain billing issues for service and subscription costs that are issued to customers. The proposed system is built utilizing the rapid application development (RAD) methodology. This method enables rapid system development. Furthermore, the RAD technique requires user participation during system development. The system was created using the PHP programming language, the CodeIgniter 3 framework, and MySQL as the database. It also utilizes the PHP WhatsApp Gateway API. The final outcome is a web-based billing tracking system that will send billing information to consumers via WhatsApp and email, as well as a notification of payment.
Rancang Bangun Aplikasi Logbook Maintenance Berbasis Web Pada BBMKG Wilayah I Medan
Authors: Samsudin Samsudin , Rasyad Ismi Hamidah , Rangkuti Faiz Wahyu Perdana
Published: April 2024

Penggunaan teknologi website menjadi solusi efektif bagi BBMKG Wilayah I Medan dalam mengatasi kendala pengelolaan maintenance peralatan yang masih menggunakan logbook manual. Dengan membangun aplikasi logbook maintenance berbasis website menggunakan metode RAD dari SDLC, teknisi dapat mengelola data peralatan, akun, crew, maintenance, serta laporan secara efisien. Tahap analisis sistem dan pemodelan menggunakan UML menjadi dasar perancangan sistem yang diimplementasikan. Dengan penggunaan bahasa pemrograman PHP dan server database MySql, aplikasi ini berhasil meningkatkan efektivitas teknisi, menghasilkan informasi yang akurat, dan meminimalkan kesalahan data. Diharapkan aplikasi ini menjadi solusi efektif dalam mengelola maintenance peralatan BBMKG Wilayah I Medan dan mendukung transformasi digital yang sedang berkembang pesat.
Analisis Pengukuran Produktivitas di PT Powertek Industri Mandiri dengan Metode Omax (Objective Matrix)
Authors: Ariyanda Fashal , Priyana Efta Dhartika
Published: April 2024

PT. Powertek Industri Mandiri adalah perusahaan yang bergerak di bidang  jasa service servo, inverter (VFD) dan panel, dalam pelaksaaan magang di PT. Powertek Industri Mandiri mengalami kendala dalam hal produktivitas yang banyak tidak terselesaikan. Sesuai dengan permssalahan yang dialami penggunaan metode OMAX diharapkan bisa menyelesaikan kendala dalam hal produktivitas, data yang digunakan adalah data wawancara dan data job order masuk dan terselesaikan. Dari hasil analisa didapatkan hasil yaitu produktivitas paling baik terjadi pada bulan agustus 2022 dengan hasil 750, dan produktivitas terburuk terjadi pada bulan maret dan desember dengan hasil 400. Dilanjutkan dengan penggunaan metode TLS yang bertujuan untuk mengetahui kualitas, dan kuantitas  yang berpengaruh terhadap produktivitas perusahaan.
DUYGUSAL ZEKANIN İŞLETMELERDE PSİKOSOSYAL RİSKLER İLE BAŞA ÇIKMA STRATEJİLERİ OLUŞTURMADA ETKİSİ; SİSTEMATİK BİR DERLEME
Authors: Akalp Hüsre Gizem , Erkasap Ahmet
Published: April 2024

İşletmelerde insana verilen önemin artması, bireylerin daha sağlıklı ve güvenli ortamlarda çalışabilmesi için gerçekleştirilen sistemli İş Sağlığı ve Güvenliği çalışmaları, öncelikle işletmelerde var olan fiziksel, kimyasal, biyolojik risklere yoğunlaşmış ardından ergonomik riskler değerlendirmeye de alınarak ergonomik çalışma ortamlarının tasarlanması ile güven veren çalışma ortamları oluşturulmaya çalışılmıştır. Ancak insanoğlu duygusal bir varlıktır. Bireylerin yaptıkları işi farkındalık ile birleştirilerek yaşadıkları duygusal değişikliklerin kontrolünün sağlanması gerekmektedir. Duygusal değişikliklerini kontrol edemeyen kişiler stres ve tükenmeyi daha kolay yaşamakta iş hayatında karşı karşıya kaldıkları rol çatışması ve aşırı iş yükü gibi durumlarla kolay kolay baş edememektedirler. Duygu durumlarının incelenmesi bağlamında duygusal zekanın da işletmelerde değerlendirilmeye alınması özellikle iş sağlığı ve güvenliğindeki risklerin psikososyal boyutu ve psikososyal risklerin değerlendirilmesi açısından oldukça önem arz etmektedir. Bu araştırma, duygusal zekâ ve psikososyal risklerden stres ve tükenmişlik ile ilgili yapılmış̧ olan akademik çalışmaların sistematik olarak derlemesini yapmayı amaçlamaktadır. Bu amaç ile tespit edilen makalelerin metodolojileri, kavramsal ve demografik değişkenleri ve temel bulguları sistematik olarak analiz edilmiş ve değerlendirilmiştir. Literatür taraması sonucunda belirlenen kriterlere ait son on yılda yayımlanmış 64 uluslararası makale değerlendirilmiş ve duygusal zeka, iş stresi, tükenmişlik arasındaki ilişkiler bulunmuştur.
RESOCIALIZATION OF CONVICTS: SOME THEORETICAL AND LEGAL ASPECTS
Authors: Skiba Andrey
Published: April 2024

When considering various aspects of the re-socialization of convicts, its inadequate theoretical elaboration and insufficient focus on post-penitentiary prevention of the commission of new crimes were established. The article reveals numerous shortcomings of criminal, penal enforcement and other legislation regulating the institution of resocialization of convicts. It is concluded that even with the participation of the court deciding on the early release of a convicted person from serving imprisonment (parole, release from punishment due to a serious illness of the convicted person or replacement of the unserved part of the deprivation of liberty with a milder type of punishment), post- penitentiary issues are not sufficiently taken into account. The article substantiates the provision that when making such a decision, the court should take into account the possibility (not) of achieving the goals of penal enforcement legislation, the forecast of post-penitentiary behavior of a person, the likelihood of committing a new crime or other offense, as well as the need to provide him with appropriate assistance.
Macrofaunal diversity patterns in coastal marine sediments: re-examining common metrics and methods
Authors: Clinton ME , Snelgrove PVR , Bates AE
Published: April 2024

Complex biodiversity patterns arise in marine systems due to overlapping ecological processes, including organism interactions, resource distribution, and environmental conditions. Despite the importance of documenting these patterns, describing diversity in natural ecosystems remains challenging. Here, we investigate 3 nearshore sub-Arctic sites to describe benthic macroinfaunal taxa and biological traits, with the ultimate aim of determining whether common diversity metrics and typical sampling efforts adequately capture community composition in these systems. First, we assess how diversity relates to sediment depth and examine relationships among commonly used taxonomic and functional diversity indices. Second, using a power analysis, we explore how sampling effort influences the interpretation of diversity patterns in coastal systems. We report significant variation in community composition among sites, even across small spatial scales of km, and find that taxonomically diverse communities do not necessarily correspond to high functional diversity. We further find that although environmental factors such as sediment depth consistently affect macroinfaunal diversity, the direction and magnitude of these relationships are site-dependent. Finally, we demonstrate that typical sampling effort for coastal benthic studies (for example, <5 push cores of ~7 cm diameter) may not capture macroinfaunal community composition adequately, potentially obscuring hotspots in common diversity metrics such as taxonomic or functional richness. However, indices such as Simpson’s diversity may be well-suited to resource-limited studies with restricted sampling capacity. Our results highlight the importance of adopting multi-pronged approaches to biodiversity assessment and determining optimal sample sizes for marine benthic systems, particularly in the context of biodiversity monitoring for conservation purposes.
Evolução do infarto agudo do miocárdio entre 2008 e 2022
Authors: Rangel Tura Bernardo
Published: April 2024

Não existe resumo para notas técnicas
Editorial de apresentação nova edição
Authors: De Lorenzo Andrea
Published: April 2024

Prezados leitores,
É com grande satisfação que apresentamos mais uma edição da revista OnScience, com artigos muito interessantes e variados. Há novidades, como o software-protótipo para o cuidado do cateter central de inserção periférica Correia, et al. (1) e a telerreabilitação em fisioterapia cardiovascular Florido, et al. (2) um relato de caso de condição rara dos Santos, et al. (3) e duas publicações de cunho epidemiológico, que abordam condições de grande importância atual (o infarto agudo do miocárdio, por BR Tura (4), e a obesidade, por Migowski & Costa (5). Estas duas últimas refletem o trabalho, respectivamente, do Núcleo de Bioestatística e Bioinformática (NBB) e do Observatório de Doenças Cardiovasculares do INC, levando o Instituto a demonstrar sua liderança no conhecimento em saúde cardiovascular no Brasil.
Acreditamos que a leitura será proveitosa!
Examining Student Perception on Mobile Augmented Reality Integration, Gender Differences, Learning Styles, Feedback, Challenges, and Opportunities in an Online Physics Class
Authors:   Department of Science Education, Br. Andrew Gonzalez FSC College of Education, De La Salle University, Manila, Philippines, Bangga-Modesto Dionafer
Published: April 2024

This study aimed to investigate the perception of STEM students (n = 147) on using mobile Augmented Reality (AR) across gender and learning styles in physics online classes. It utilized embedded mixed-method research and purposive sampling. An instrument named Students Perception in Integrating Mobile AR in Physics Class was developed and has undergone a series of validations such as item generation from literature review, content validation, cognitive interview, pilot testing, and exploratory factor analysis revealing two factors, CFA with indices that are of acceptable value, and good Cronbach alpha (α = 0.86) for reliability. Mean, standard deviation, percentages, two samples t-test, and thematic analysis were used to analyze the data. Results revealed that all students have a source of internet connection as well as a device to use and most of them have a very stable to somewhat stable internet connection. Positive feedback was shown in terms of overall learning experience and perception across gender and learning styles. However, in terms of overall usability, females have more ease of use compared to males and kinesthetic learners only have a positive response. It was also found that there is no significant difference across gender. Moreover, the integration of AR in a physics lesson has received excellent responses from both students with and without prior experience in a classroom setting. All of the difficulties the students encountered were technological in nature. There are also opportunities to improve the integration of mobile AR in the technical and learning process. These results suggest that teachers should integrate mobile AR in online physics classes but should consider factors such as Internet connection, device, gender, and learning styles in developing the application.
Hierarchical Organization in Concept Maps as a path to explain the Elaboration of Knowledge in the History of Science
Authors:   Department of Physics, Instituto Federal do Rio de Janeiro-campus Volta Redonda, Brazil, Souza Paulo Victor ,   Laboratório de Pesquisa em Ensino e Divulgação da Ciência (LAPED)-Universidade Federal Fluminense, Rio de Janeiro, Brazil, Pereira Marta Máximo ,   Centro Federal de Educação Tecnológica Celso Suckow da Fonseca - campus Nova Iguaçu, Brazil; Laboratório de Pesquisa em Ensino de Ciências (LAPEC), Brazil, Lourenço Ariane Baffa ,   Centro de Síntese USP Cidades GlobaisInstituto de Estudos Avançados - Polo São Carlos, Brazil
Published: April 2024

An alternative to insert history of science (HS) in teacher formation programs is the use of concept maps (CM), which may be very useful to represent the historical elaboration dimension of science concepts, laws, and principles. This paper presents the results of a study that identifies the conceptions of pre-service physics teachers about the relationships between CM hierarchical organization and knowledge elaboration in HS. In the first stage of the research, the content analysis methodology was used to analyze and categorize the students’ answers to questions concerning the relationships between CM hierarchical organization and HS. In the second stage, the answers of a different group of pre-service teachers were analyzed concerning the level of agreement with the categories previously elaborated. The students associated CM hierarchical organization with knowledge improvement, elucidation of the importance level of the concepts, and the relationships between more general and more specific contents. We point out that the use of CM in HS subjects may contribute to the pre-service teachers associating HS concepts not in a chronological way, but in hierarchical order, from the most general to the most specific ones.
Editorial
Authors:   Dokuz Eylul University, Usak University, Uşak, Turkey, Cavas Bulent
Published: April 2024

Editorial, Volume 35, Issue 1
Discourses on quality in Swedish adult education
Authors: Andersson Per , Muhrman Karolina
Published: April 2024

Swedish municipal adult education has many providers. The overall responsibility for this service still lies with the municipalities, entailing the enactment of national policy with respect to providers. This study puts focus on the discursive enactment of policy concerning quality in adult education. Five discourses on quality are identified through interviews with school leaders, teachers, and students, namely that quality is about formal demands and processes, that it is a matter of student focus, that it is about teachers’ competence and working conditions, that it is about teaching, and that quality depends on the student group. School leaders focus on formal and organisational aspects of quality, while teachers and students focus on actual processes in the classroom, connecting to their own work and lives. Compared to national policy, the local discourses are limited mainly to studying, teaching, organisation, and short-term outcomes, while long-term aims in national policy are less prominent.
Estimating 3D kinematics and kinetics from virtual inertial sensor data through musculoskeletal movement simulations
Authors: Nitschke Marlies , Dorschky Eva , Leyendecker Sigrid , Eskofier Bjoern M. , Koelewijn Anne D.
Published: April 2024

Portable measurement systems using inertial sensors enable motion capture outside the lab, facilitating longitudinal and large-scale studies in natural environments. However, estimating 3D kinematics and kinetics from inertial data for a comprehensive biomechanical movement analysis is still challenging. Machine learning models or stepwise approaches performing Kalman filtering, inverse kinematics, and inverse dynamics can lead to inconsistencies between kinematics and kinetics. We investigated the reconstruction of 3D kinematics and kinetics of arbitrary running motions from inertial sensor data using optimal control simulations of full-body musculoskeletal models. To evaluate the feasibility of the proposed method, we used marker tracking simulations created from optical motion capture data as a reference and for computing virtual inertial data such that the desired solution was known exactly. We generated the inertial tracking simulations by formulating optimal control problems that tracked virtual acceleration and angular velocity while minimizing effort without requiring a task constraint or an initial state. To evaluate the proposed approach, we reconstructed three trials each of straight running, curved running, and a v-cut of 10 participants. We compared the estimated inertial signals and biomechanical variables of the marker and inertial tracking simulations. The inertial data was tracked closely, resulting in low mean root mean squared deviations for pelvis translation (≤20.2 mm), angles (≤1.8 deg), ground reaction forces (≤1.1 BW%), joint moments (≤0.1 BWBH%), and muscle forces (≤5.4 BW%) and high mean coefficients of multiple correlation for all biomechanical variables (≥0.99). Accordingly, our results showed that optimal control simulations tracking 3D inertial data could reconstruct the kinematics and kinetics of individual trials of all running motions. The simulations led to mutually and dynamically consistent kinematics and kinetics, which allows researching causal chains, for example, to analyze anterior cruciate ligament injury prevention. Our work proved the feasibility of the approach using virtual inertial data. When using the approach in the future with measured data, the sensor location and alignment on the segment must be estimated, and soft-tissue artifacts are potential error sources. Nevertheless, we demonstrated that optimal control simulation tracking inertial data is highly promising for estimating 3D kinematics and kinetics for a comprehensive biomechanical analysis.
The role of the Pin1-cis P-tau axis in the development and treatment of vascular contribution to cognitive impairment and dementia and preeclampsia
Authors: Qiu Chenxi , Li Zhixiong , Leigh David A. , Duan Bingbing , Stucky Joseph E. , Kim Nami , Xie George , Lu Kun Ping , Zhou Xiao Zhen
Published: April 2024

Tauopathies are neurodegenerative diseases characterized by deposits of abnormal Tau protein in the brain. Conventional tauopathies are often defined by a limited number of Tau epitopes, notably neurofibrillary tangles, but emerging evidence suggests structural heterogeneity among tauopathies. The prolyl isomerase Pin1 isomerizes cis P-tau to inhibit the development of oligomers, tangles and neurodegeneration in multiple neurodegenerative diseases such as Alzheimer’s disease, traumatic brain injury, vascular contribution to cognitive impairment and dementia (VCID) and preeclampsia (PE). Thus, cis P-tau has emerged as an early etiological driver, blood marker and therapeutic target for multiple neurodegenerative diseases, with clinical trials ongoing. The discovery of cis P-tau and other tau pathologies in VCID and PE calls attention for simplistic classification of tauopathy in neurodegenerative diseases. These recent advances have revealed the exciting novel role of the Pin1-cis P-tau axis in the development and treatment of vascular contribution to cognitive impairment and dementia and preeclampsia.
Efficacy and classification of Sesamum indicum linn seeds with Rosa damascena mill oil in uncomplicated pelvic inflammatory disease using machine learning
Authors: Sumbul  , Sultana Arshiya , Heyat Md Belal Bin , Rahman Khaleequr , Akhtar Faijan , Parveen Saba , Urbano Mercedes Briones , Lipari Vivian , De la Torre Díez Isabel , Khan Azmat Ali , Malik Abdul
Published: April 2024

Background and objectives: As microbes are developing resistance to antibiotics, natural, botanical drugs or traditional herbal medicine are presently being studied with an eye of great curiosity and hope. Hence, complementary and alternative treatments for uncomplicated pelvic inflammatory disease (uPID) are explored for their efficacy. Therefore, this study determined the therapeutic efficacy and safety of Sesamum indicum Linn seeds with Rosa damascena Mill Oil in uPID with standard control. Additionally, we analyzed the data with machine learning.

Materials and methods: We included 60 participants in a double-blind, double-dummy, randomized standard-controlled study. Participants in the Sesame and Rose oil group (SR group) (n = 30) received 14 days course of black sesame powder (5 gm) mixed with rose oil (10 mL) per vaginum at bedtime once daily plus placebo capsules orally. The standard group (SC), received doxycycline 100 mg twice and metronidazole 400 mg thrice orally plus placebo per vaginum for the same duration. The primary outcome was a clinical cure at post-intervention for visual analogue scale (VAS) for lower abdominal pain (LAP), and McCormack pain scale (McPS) for abdominal-pelvic tenderness. The secondary outcome included white blood cells (WBC) cells in the vaginal wet mount test, safety profile, and health-related quality of life assessed by SF-12. In addition, we used AdaBoost (AB), Naïve Bayes (NB), and Decision Tree (DT) classifiers in this study to analyze the experimental data.

Results: The clinical cure for LAP and McPS in the SR vs SC group was 82.85% vs 81.48% and 83.85% vs 81.60% on Day 15 respectively. On Day 15, pus cells less than 10 in the SR vs SC group were 86.6% vs 76.6% respectively. No adverse effects were reported in both groups. The improvement in total SF-12 score on Day 30 for the SR vs SC group was 82.79% vs 80.04% respectively. In addition, our Naive Bayes classifier based on the leave-one-out model achieved the maximum accuracy (68.30%) for the classification of both groups of uPID.

Conclusion: We concluded that the SR group is cost-effective, safer, and efficacious for curing uPID. Proposed alternative treatment (test drug) could be a substitute of standard drug used for Female genital tract infections.
Integration of Wnt-inhibitory activity and structural novelty scoring results to uncover novel bioactive natural products: new Bicyclo[3.3.1]non-3-ene-2,9-diones from the leaves of Hymenocardia punctata
Authors: Quiros-Guerrero Luis-Manuel , Marcourt Laurence , Chaiwangrach Nathareen , Koval Alexey , Ferreira Queiroz Emerson , David Bruno , Grondin Antonio , Katanaev Vladimir L. , Wolfender Jean-Luc
Published: April 2024

In natural products (NPs) research, methods for the efficient prioritization of natural extracts (NEs) are key for discovering novel bioactive NPs. In this study a biodiverse collection of 1,600 NEs, previously analyzed by UHPLC-HRMS2 metabolite profiling was screened for Wnt pathway regulation. The results of the biological screening drove the selection of a subset of 30 non-toxic NEs with an inhibitory IC50 ≤ 5 μg/mL. To increase the chance of finding structurally novel bioactive NPs, Inventa, a computational tool for automated scoring of NEs based on structural novelty was used to mine the HRMS2 analysis and dereplication results. After this, four out of the 30 bioactive NEs were shortlisted by this approach. The most promising sample was the ethyl acetate extract of the leaves of Hymenocardia punctata (Phyllanthaceae). Further phytochemical investigations of this species resulted in the isolation of three known prenylated flavones (3, 5, 7) and ten novel bicyclo[3.3.1]non-3-ene-2,9-diones (1, 2, 4, 6, 8–13), named Hymenotamayonins. Assessment of the Wnt inhibitory activity of these compounds revealed that two prenylated flavones and three novel bicyclic compounds showed interesting activity without apparent cytotoxicity. This study highlights the potential of combining Inventa’s structural novelty scores with biological screening results to effectively discover novel bioactive NPs in large NE collections.
Francisella tularensis-specific antibody levels in sera from Swedish patients with suspected tularemia during a 13-year period
Authors: Lindgren Helena , Liu Xijia , Sjöstedt Anders
Published: April 2024

Introduction

For a majority of tularemia patients, serology is the basis for the diagnosis. The aim of this study was to perform an analysis of the samples analyzed at a Swedish reference laboratory for the presence of Francisella tularensis-specific antibody levels in sera from individuals with suspected tularemia. Annual and monthly variations of the total number of samples and proportions of positive samples were analyzed, as well as the influence of age and gender.

Methods

We performed a retrospective analysis of the presence of F. tularensis-specific antibodies in serological samples from patients with suspected tularemia analyzed during the period 2010 - 2022 at the University Hospital of Umeå in Sweden, a national reference laboratory, by use of various statistical methods. In total, some 15,100 serum samples had been analyzed for the presence of IgG and IgM antibodies by ELISA during the 13-year period.

Results

Overall, there were higher number of samples with IgG positive or borderline titers, 2,522 and 921, respectively, than with IgM positive or borderline titers, 1,802 and 409, respectively. Repeated samples were obtained from some 1,930 individuals and approximately a third of the cases, which were initially seronegative, had seroconverted when resampled. Peak number of monthly samples were recorded in August and September, > 3,000. Annual numbers varied greatly and peak numbers were observed in 2015 and 2019, 1,832 and 2,250, respectively, whereas some other years the numbers were 700 – 800. There was also much variation in the annual and monthly percentages of positive samples and they varied between less than 10% to greater than 20%. The highest percentages of positive samples were recorded in September and October. IgG and IgM titers declined with age and these differences were highly significant for IgG titers, with decreasing average titers for each 20-year interval.

Discussion

Collectively, the data demonstrate the marked annual and seasonal variations in tularemia sampling occurring in Sweden. Also, the proportion of positive samples increased during months and years with peak number of samples. Another notable finding was that average antibody titers decreased with increased age.