bluuebunny/crossref_metadata_2025 huggingface dataset:
Geology, U–Pb zircon geochronology, and geochemistry of PGE-bearing Neoarchean and Paleoproterozoic gabbroic rocks of the Peter Lake domain, southern Hearne craton, Canada
Authors: Maxeiner Ralf O. , Rayner Nicole M.
Published: February 2017

The Peter Lake domain, a component of the Hearne craton in Saskatchewan, includes several intrusive complexes ranging in age from 2.70 to 1.83 Ga. Two gabbroic complexes (Swan River and Porter Bay) together represent one of the largest accumulations of Precambrian mafic intrusion, both metamorphosed at amphibolite facies. Sulfide-poor PGE occurrences are found in both complexes and share many textural and lithological characteristics with magmatic contact-type PGE–(Ni–Cu) deposits such as the chaotic Lac des Iles pluton and with layered stratiform deposits of large layered intrusions such as Bushveld or Stillwater. Lithologically, both complexes are dominated by leucocratic gabbronorite and gabbro, locally characterized by cumulate layering, cross-bedding, brecciated, and pegmatitic textures. U–Pb zircon crystallization ages between 2562 and 2560 Ma were obtained for the Swan River complex. sulfide formation is interpreted to be of magmatic origin rather than remobilized, as had been speculated by exploration geologists, and is therefore of the same age as the host gabbro. Geochemical data support the interpretation of a mantle plume origin in a subduction environment for the Swan River complex. The Porter Bay complex is much more restricted in areal extent and a leucocratic gabbronorite yielded a U–Pb zircon age of 1913 ± 1 Ma, which is interpreted as the crystallization age and the time of sulfide formation. Major and trace element geochemical data of Porter Bay complex rocks show a considerably more evolved character than the Swan River complex, and is interpreted as indicating emplacement in a continental arc environment.
A study of partial layout of adhesive on the thermal drift of MEMS capacitive accelerometers
Authors: Peng Peng , Zhou Wu , Yu Huijun , Hao Qu , Peng Bei , He Xiaoping
Published: February 2017

The die attachment adhesive is commonly fully deposited on the substrate to connect the chips and the package shell in the packaging of microelectromechanical system (MEMS) devices. The packaging stress and deformation will be changed under temperature variation and further impact the thermal stability of devices. This paper describes a partial layout of die attachment adhesive used in a comb MEMS capacitive accelerometer, which can attenuate the thermal deformation and reduce the thermal drift of the sensor. The accelerometers with the bonded area designed from the global portion to nonsensitive portion of the sensor die are modeled by using finite element analysis (FEA) to study the deformation of the sensitive component induced by temperature change, and the corresponding thermal drift is obtained by simulation and theoretical methods. Both the results indicate that the thermal drift will decrease when the length of the unbonded area is larger than about 700 μm, and when the adhesive bonds only in the area of the nonsensitive portion of the sensor, the thermal drift will reduce about 19% relative to the global attachment. The partial layout of die attachment adhesive is therefore a useful method to improve the thermal stability for stress-sensitive MEMS devices.
An assembly method for micro parts jointing with given space angle based on projection matching
Authors: Bi Lie , Wu Wenrong , Zhang Juan , Yang Honggang
Published: February 2017

It is difficult to assemble micro parts jointing with given space angle as the parts assembled are not on the same flat and the visual depth of microscopic vision is small, which can cause the images gathered by the microscopic vision unintelligible and feature extraction difficult. For the problem, this paper presents an assembly method of micro parts based on projection matching. It can assemble micro parts jointing with given space angle accurately. Firstly, an ideal assembly model is established as the size of the micro parts through the drawing software. Secondly, a graphics algorithm based on the primitive information from CAD is designed. Thirdly, according to the pixel value calibration and the graphics algorithm, the projection pictures are shown on the control interface. Lastly, the control method of micro parts is proposed to assemble them with given space angle. And we accomplished an assembly experiment of micro-tube and micro-column in this way, whose assembly deviation is 0.12[Formula: see text]. Experiment results indicate that the angle between two micro parts assembled can be controlled within the given deviation.
Structural characterization of Zn–In–Se thin films
Authors: Güllü H. H. , Parlak M.
Published: February 2017

In this study, structural properties of the Zn–In–Se (ZIS) thin films deposited by thermal evaporation method were investigated. The as-grown and annealed ZIS films were found in polycrystalline structure with the main orientation in (112) direction. The compositional analysis of the films showed that they were in Zn-rich behavior and there was a slight change in the elemental contribution to the structure with annealing process. Raman analysis was carried out to determine the crystalline structure and the different vibration modes of ZIS thin films. According to these measurements, the highest Raman intensity was in the LO mode which was directly proportional to the crystallinity of the samples. The atomic force microscopy (AFM) analyses were done in order to obtain detailed information about the morphology of the thin film surface. The surface of the films was observed as nearly-smooth and uniform in as-grown and annealed forms. X-ray photoelectron spectroscopy (XPS) measurements were analyzed to get detailed information about surface and near-surface characteristics of the films. The results from the surface and depth compositional analyses of the films showed quite good agreement with the energy dispersive X-ray spectroscopy (EDS) analysis.
Roadmap to the Future
Authors: Colby Eric R. , Len L. K.
Published: February 2017

Most particle accelerators today are expensive devices found only in the largest laboratories, industries, and hospitals. Using techniques developed nearly a century ago, the limiting performance of these accelerators is often traceable to material limitations, power source capabilities, and the cost tolerance of the application. Advanced accelerator concepts a aim to increase the gradient of accelerators by orders of magnitude, using new power sources (e.g. lasers and relativistic beams) and new materials (e.g. dielectrics, metamaterials, and plasmas). Worldwide, research in this area has grown steadily in intensity since the 1980s, resulting in demonstrations of accelerating gradients that are orders of magnitude higher than for conventional techniques. While research is still in the early stages, these techniques have begun to demonstrate the potential to radically change accelerators, making them much more compact, and extending the reach of these tools of science into the angstrom and attosecond realms. Maturation of these techniques into robust, engineered devices will require sustained interdisciplinary, collaborative R&D and coherent use of test infrastructure worldwide. The outcome can potentially transform how accelerators are used.
Laser-Driven Plasma Electron Acceleration and Radiation
Authors: Nakajima Kazuhisa
Published: February 2017

Laser-driven plasma acceleration of electron beams is reviewed from the viewpoint of the underlying physics and recent progress in the experimental research. Betatron radiation cogenerated from laser plasma accelerators is mentioned in terms of electron beam dynamics and the radiation spectrum. At the end, future perspectives of possible applications are presented.
Dielectric Wakefield Accelerators
Authors: Jing Chunguang
Published: February 2017

Dielectric-structure-based wakefield acceleration provides a viable approach to achieving the luminosity, efficiency, and cost requirements of a future linear collider as well as future x-ray light sources. This technology is capable of accelerating electrons and positrons at the substantially high gradients needed. Important progress in the development of dielectric wakefield accelerators has been made both experimentally and theoretically in the past few years. In this article we provide an overview of the basics of dielectric wakefield acceleration and major developments to date.
Laser Technology for Advanced Acceleration: Accelerating Beyond TeV
Authors: Wheeler Jonathan , Mourou Gérard , Tajima Toshiki
Published: February 2017

The implementation of the suggestion of thin film compression (TFC) allows the newest class of high power, ultrafast laser pulses (typically 20[Formula: see text]fs at near-infrared wavelengths) to be compressed to the limit of a single-cycle laser pulse (2[Formula: see text]fs). Its simplicity and high efficiency, as well as its accessibility to a single-cycle laser pulse, introduce a new regime of laser–plasma interaction that enhances laser acceleration. Single-cycle laser acceleration of ions is a far more efficient and coherent process than the known laser-ion acceleration mechanisms. The TFC-derived single-cycle optical pulse is capable of inducing a single-cycle X-ray laser pulse (with a far shorter pulse length and thus an extremely high intensity) through relativistic compression. The application of such an X-ray pulse leads to the novel regime of laser wakefield acceleration of electrons in the X-ray regime, yielding a prospect of “TeV on a chip.” This possibility of single-cycle X-ray pulses heralds zeptosecond and EW lasers (and zeptoscience). The additional invention of the coherent amplification network (CAN) fiber laser pushes the frontier of high repetition, high efficiency lasers, which are the hallmark of needed applications such as laser-driven LWFA colliders and other, societal applications. CAN addresses the crucial aspect of intense lasers that have traditionally lacked the above properties.
POMC Neurons: From Birth to Death
Authors: Toda Chitoku , Santoro Anna , Kim Jung Dae , Diano Sabrina
Published: February 2017

The hypothalamus is an evolutionarily conserved brain structure that regulates an organism's basic functions, such as homeostasis and reproduction. Several hypothalamic nuclei and neuronal circuits have been the focus of many studies seeking to understand their role in regulating these basic functions. Within the hypothalamic neuronal populations, the arcuate melanocortin system plays a major role in controlling homeostatic functions. The arcuate pro-opiomelanocortin (POMC) neurons in particular have been shown to be critical regulators of metabolism and reproduction because of their projections to several brain areas both in and outside of the hypothalamus, such as autonomic regions of the brain stem and spinal cord. Here, we review and discuss the current understanding of POMC neurons from their development and intracellular regulators to their physiological functions and pathological dysregulation.
Macrophages in Renal Injury and Repair
Authors: Huen Sarah C. , Cantley Lloyd G.
Published: February 2017

Acute kidney injury (AKI) is a growing global health concern, yet no treatment is currently available to prevent it or to promote kidney repair after injury. Animal models demonstrate that the macrophage is a major contributor to the inflammatory response to AKI. Emerging data from human biopsies also corroborate the presence of macrophages in AKI and their persistence in progressive chronic kidney disease. Macrophages are phagocytic innate immune cells that are important mediators of tissue homeostasis and host defense. In response to tissue injury, macrophages become activated based on specific signals from the damaged microenvironment. The activation and functional state of the macrophage depends on the stage of tissue injury and repair, reflecting a dynamic and diverse spectrum of macrophage phenotypes. In this review, we highlight our current understanding of the mechanisms by which macrophages contribute to injury and repair after AKI.
Preoperative Antihypertensive Medication in Relation to Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: A Meta-Analysis
Authors: Zhou Ai-Guo , Wang Xian-Xue , Pan Dao-Bo , Chen An-ji , Zhang Xiong-fei , Deng Hui-wei
Published: February 2017

Background. We undertake a systematic review and meta-analysis to evaluate the effect of preoperative hypertension and preoperative antihypertensive medication to postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery. Methods. We searched PubMed, Embase, and Cochrane Library (from inception to March 2016) for eligible studies. The outcomes were the effects of preoperative hypertension, preoperative calcium antagonists regimen, preoperative ACE inhibitors regimen, and preoperative beta blocking agents regimen with POAF. We calculated pooled risk ratios (OR) and 95% CIs using random- or fixed-effects models. Results. Twenty-five trials involving 130087 patients were listed. Meta-analysis showed that the number of preoperative hypertension patients in POAF group was significantly higher (P<0.05), while we found that there are no significant differences between two groups in Asia patients by subgroup analysis, which is in contrast to other outcomes. Compared with the Non-POAF group, the number of patients who used calcium antagonists and ACE inhibitors preoperatively in POAF group was significantly higher (P<0.05). And we found that there were no significant differences between two groups of preoperative beta blocking agents used (P=0.08). Conclusions. Preoperative hypertension and preoperative antihypertensive medication in patients undergoing cardiac operations seem to be associated with higher risk of POAF.
Pulmonary Hypertension Associated with Idiopathic Pulmonary Fibrosis: Current and Future Perspectives
Authors: Collum Scott D. , Amione-Guerra Javier , Cruz-Solbes Ana S. , DiFrancesco Amara , Hernandez Adriana M. , Hanmandlu Ankit , Youker Keith , Guha Ashrith , Karmouty-Quintana Harry
Published: February 2017

Pulmonary hypertension (PH) is commonly present in patients with chronic lung diseases such as Chronic Obstructive Pulmonary Disease (COPD) or Idiopathic Pulmonary Fibrosis (IPF) where it is classified as Group III PH by the World Health Organization (WHO). PH has been identified to be present in as much as 40% of patients with COPD or IPF and it is considered as one of the principal predictors of mortality in patients with COPD or IPF. However, despite the prevalence and fatal consequences of PH in the setting of chronic lung diseases, there are limited therapies available for patients with Group III PH, with lung transplantation remaining as the most viable option. This highlights our need to enhance our understanding of the molecular mechanisms that lead to the development of Group III PH. In this review we have chosen to focus on the current understating of PH in IPF, we will revisit the main mediators that have been shown to play a role in the development of the disease. We will also discuss the experimental models available to study PH associated with lung fibrosis and address the role of the right ventricle in IPF. Finally we will summarize the current available treatment options for Group III PH outside of lung transplantation.
ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases
Authors: Filippi Alexandru , Ciolac Oana-Alina , Ganea Constanța , Mocanu Maria-Magdalena
Published: February 2017

ErbB proteins overexpression, in both normal and mutated forms, is associated with invasive forms of cancer prone to metastasis and with stronger antiapoptotic mechanisms and therefore more challenging to treat. Downstream effectors of ErbB receptors mediating these phenotypic traits include MAPK, STAT, and PI3K/AKT/mTOR pathways. Various phytochemical compounds were studied for their large number of biological effects including anticancer activity. Among these compounds, epigallocatechin-3-gallate (EGCG), the main catechin from green tea leaves, and curcumin, component of the curry powder, constituted the object of numerous studies. Both compounds were shown to act directly either on ErbB expression, or on their downstream signaling molecules. In this paper we aim to review the involvement of ErbB proteins in cancer as well as the biologic activity of EGCG and curcumin in ErbB expressing and overexpressing malignancies. The problems arising in the administration of the two compounds due to their reduced bioavailability when orally administered, as well as the progress made in this field, from using novel formulations to improved dosing regimens or improved synthetic analogs, are also discussed.
Aneurysms of Peripancreatic Arterial Arcades Coexisting with Celiac Trunk Stenosis or Occlusion: Single Institution Experience
Authors: Antoniak Robert , Grabowska-Derlatka Laretta , Nawrot Ireneusz , Cieszanowski Andrzej , Rowiński Olgierd
Published: February 2017

Introduction. True aneurysms of peripancreatic arterial arcades (PAAAs) are rare. Most of them coexist with celiac axis stenosis/occlusion due to median arcuate ligament (MAL) compression or atherosclerosis. The aim of this study was to evaluate the cause of celiac axis lesion and characterize the anatomy of the aneurysms. These findings may have important management implications. Material and Methods. A retrospective analysis of 15 patients with true PAAAs was performed. The diagnosis was established by contrast-enhanced CT, using a 64-MDCT scanner. We evaluated the most probable cause of celiac axis lesion. Aneurysms were characterized by their number, location, size, and morphology. Location of the aneurysms was classified either as pancreaticoduodenal arteries (PDA) or as dorsal pancreatic arteries (DPA) as they may represent different collateral pathways between superior mesenteric artery and celiac trunk. Results. A total of 32 true PAAAs were identified. Celiac trunk was occluded in 12 patients and critically narrowed in 3 patients. Celiac axis lesion was categorized as secondary to MAL compression in 14 cases and due to atherosclerosis in 1 case. The most common location of the aneurysms was inferior pancreaticoduodenal arteries. Only in 1 case aneurysms involved both PDA and DPA. Conclusions. Coexistence of PAAAs with celiac axis compression as well as involvement of either PDAs or DPAs has important therapeutic implications. The uninvolved collateral pathway may be sufficient to preserve effective circulation in celiac trunk branches in case of resection or embolization of the aneurysms. However, further studies are crucial to confirm our findings.
Construction of Two mCherry Plasmids (pXG-mCherry) for TransgenicLeishmania: Valuable Tools for Future Molecular Analysis
Authors: Vacas Andrés , Sugden Conor , Velasco-Rodriguez Óscar , Algarabel-Olona Miriam , Peña-Guerrero José , Larrea Esther , Fernández-Rubio Celia , Nguewa Paul A.
Published: February 2017

Leishmaniais the causative agent of leishmaniasis, a neglected tropical disease that affects more than 12 million people around the world. Current treatments are toxic and poorly effective due to the acquisition of resistance withinLeishmaniapopulations. Thus, the pursuit for new antileishmanial drugs is a priority. The available methods for drug screening based on colorimetric assays using vital dyes are time-consuming. Currently, the use of fluorescent reporter proteins is replacing the use of viability indicator dyes. We have constructed two plasmids expressing the red fluorescent protein mCherry with multiple cloning sites (MCS), adequate for N- and C-terminal fusion protein constructs. Our results also show that the improved pXG-mCherry plasmid can be employed for drug screeningin vitro. The use of the red fluorescent protein, mCherry, is an easier tool for numerous assays, not only to test pharmacological compounds, but also to determine the subcellular localization of proteins.
An Extended Flexible Job Shop Scheduling Model for Flight Deck Scheduling with Priority, Parallel Operations, and Sequence Flexibility
Authors: Yu Lianfei , Zhu Cheng , Shi Jianmai , Zhang Weiming
Published: February 2017

Efficient scheduling for the supporting operations of aircrafts in flight deck is critical to the aircraft carrier, and even several seconds’ improvement may lead to totally converse outcome of a battle. In the paper, we ameliorate the supporting operations of carrier-based aircrafts and investigate three simultaneous operation relationships during the supporting process, including precedence constraints, parallel operations, and sequence flexibility. Furthermore, multifunctional aircrafts have to take off synergistically and participate in a combat cooperatively. However, their takeoff order must be restrictively prioritized during the scheduling period accorded by certain operational regulations. To efficiently prioritize the takeoff order while minimizing the total time budget on the whole takeoff duration, we propose a novel mixed integer liner programming formulation (MILP) for the flight deck scheduling problem. Motivated by the hardness of MILP, we design an improved differential evolution algorithm combined with typical local search strategies to improve computational efficiency. We numerically compare the performance of our algorithm with the classical genetic algorithm and normal differential evolution algorithm and the results show that our algorithm obtains better scheduling schemes that can meet both the operational relations and the takeoff priority requirements.
Effect of Tumor Necrosis Factor Inhibitor Therapy on Osteoclasts Precursors in Rheumatoid Arthritis
Authors: Perpétuo Inês P. , Caetano-Lopes Joana , Rodrigues Ana Maria , Campanilho-Marques Raquel , Ponte Cristina , Canhão Helena , Ainola Mari , Fonseca João E.
Published: February 2017

Objective. Tumor necrosis factor (TNF) increases circulating osteoclast (OC) precursors numbers by promoting their proliferation and differentiation. The aim of this study was to assess the effect of TNF inhibitors (TNFi) on the differentiation and activity of OC in rheumatoid arthritis (RA) patients.Methods.Seventeen RA patients treated with TNFi were analyzed at baseline and after a minimum follow-up period of 6 months. Blood samples were collected to assess receptor activator of nuclear factor kappa-B ligand (RANKL) surface expression on circulating leukocytes and frequency and phenotype of monocyte subpopulations. Quantification of serum levels of bone turnover markers, in vitro OC differentiation assays, and qRT-PCR for OC specific genes was performed.Results. After TNFi therapy, patients had reduced RANKL surface expression in B-lymphocytes and the frequency of circulating classicalCD14brightCD16−monocytes was decreased. Serum levels of sRANKL, sRANKL/OPG ratio, and CTX-I were reduced in RA patients after TNFi treatment. Moreover, after exposure to TNFi, osteoclast differentiation and activity were decreased, as well as the expression of TRAF6 and cathepsin K.Conclusion. We propose that TNFi arrests bone loss and erosion, through two pathways: direct reduction of osteoclast precursor numbers and inhibition of intracellular signaling pathways acting through TRAF6.
Failure Characteristics of Joint Bolts in Shield Tunnels Subjected to Impact Loads from a Derailed Train
Authors: Yan Qixiang , Deng Zhixin , Zhang Yanyang , Yang Wenbo
Published: February 2017

Impact loads generated by derailed trains can be extremely high, especially in the case of heavy trains running at high speeds, which usually cause significant safety issues to the rail infrastructures. In shield tunnels, such impact loads may not only cause the damage and deformation of concrete segments, but also lead to the failure of segmental joint bolts. This paper presents a numerical study on the failure behavior of segmental joint bolts in the shield tunnel under impact loading resulting from train derailments. A three-dimensional (3D) numerical model of a shield tunnel based on the finite element (FE) modelling strategy was established, in which the structural behavior of the segmental joint surfaces and the mechanical behavior of the segmental joint bolts were determined. The numerical results show that the occurrence of bolt failure starts at the joints near the impacted segment and develops along the travel direction of train. An extensive parametric study was subsequently performed and the influences of the bolt failure on the dynamic response of the segment were investigated. In particular, the proposed FE model and the analytical results will be used for optimizing the design method of the shield tunnel in preventing the failure of the joint bolts due to the impact load from a derailed HST.
A Review of the Potential of Phytochemicals from Prunus africana (Hook f.) Kalkman Stem Bark for Chemoprevention and Chemotherapy of Prostate Cancer
Authors: Komakech Richard , Kang Youngmin , Lee Jun-Hwan , Omujal Francis
Published: February 2017

Prostate cancer remains one of the major causes of death worldwide. In view of the limited treatment options for patients with prostate cancer, preventive and treatment approaches based on natural compounds can play an integral role in tackling this disease. Recent evidence supports the beneficial effects of plant‐derived phytochemicals as chemopreventive and chemotherapeutic agents for various cancers, including prostate cancer. Prunus africana has been used for generations in African traditional medicine to treat prostate cancer. This review examined the potential roles of the phytochemicals from P. africana, an endangered, sub‐Saharan Africa plant in the chemoprevention and chemotherapy of prostate cancer. In vitro and in vivo studies have provided strong pharmacological evidence for antiprostate cancer activities of P. africana‐derived phytochemicals. Through synergistic interactions between different effective phytochemicals, P. africana extracts have been shown to exhibit very strong antiandrogenic and antiangiogenic activities and have the ability to kill tumor cells via apoptotic pathways, prevent the proliferation of prostate cancer cells, and alter the signaling pathways required for the maintenance of prostate cancer cells. However, further preclinical and clinical studies ought to be done to advance and eventually use these promising phytochemicals for the prevention and chemotherapy of human prostate cancer.
Interobserver Agreement in Magnetic Resonance of the Sacroiliac Joints in Patients with Spondyloarthritis
Authors: Rueda Juan C. , Arias-Correal Sofia , Vasquez Andres Y. , Calvo Enrique , Peña Paola , Porras Marlon , Angarita Jose-Ignacio , Saldarriaga Eugenia-Lucia , Santos Ana M. , Londono John
Published: February 2017

Background. Clinical, laboratory, and radiologic parameters are used for diagnosis and classification of spondyloarthritis (SpA). Magnetic resonance imaging (MRI) of sacroiliac (SI) joints is being increasingly used to detect early sacroiliitis. We decided to evaluate the interobserver agreement in MRI findings of SI joints of SpA patients between a local radiologist, a rheumatologist, and an expert radiologist in musculoskeletal diseases. Methods. 66 MRI images of the SI joints of patients with established diagnosis of SpA were evaluated. Agreement was expressed in Cohen’s kappa. Results. Interobserver agreement between a local radiologist and an expert radiologist was fair (κ=0.37). Only acute findings showed a moderate agreement (κ=0.45), while chronic findings revealed 76.5% of disagreement (κ=0.31). A fair agreement was observed in acute findings (κ=0.38) as well as chronic findings (κ=0.38) between a local radiologist and a rheumatologist. There was a substantial agreement between an expert radiologist and a rheumatologist (κ=0.73). In acute findings, a 100% agreement was achieved. Also chronic and acute plus chronic findings showed high levels of agreement (κ=0.73 and 0.62, resp.). Conclusions. Our study shows that rheumatologists may have similar MRI interpretations of SI joints in SpA patients as an expert radiologist.
The Effect of Exercise Intensity on Total PYY and GLP-1 in Healthy Females: A Pilot Study
Authors: Hallworth Jillian R. , Copeland Jennifer L. , Doan Jon , Hazell Tom J.
Published: February 2017

We compared the acute response of anorexigenic signals (total PYY and GLP-1) in response to submaximal and supramaximal exercise. Nine females completed three sessions: (1) moderate-intensity continuous training (MICT; 30 min; 65%  VO2max); (2) sprint interval training (SIT; 6 × 30 sec “all-out” cycling sprints with 4 min recovery); or (3) control (CTRL; no exercise). PYY and GLP-1 were measured via blood samples drawn before, immediately after, and 90 min after exercise. Perceptions of hunger were rated using a visual analogue scale at all blood sampling time points. There was a session × time interaction for GLP-1 (p=0.004) where SIT and MICT (p<0.015 and p<0.001) were higher compared to CTRL both immediately and 90 min after exercise. There was a main effect of time for PYY where 90 min after exercise it was decreased versus before and immediately after exercise. There was a session × time interaction for hunger with lower ratings following SIT versus MICT (p=0.027) and CTRL (p=0.031) 90 min after exercise. These results suggest that though GLP-1 is elevated after exercise in women, it is not affected by exercise intensity though hunger was lower 90 min after exercise with SIT. As the sample size is small further study is needed to confirm these findings.
Emerging and Neglected Infectious Diseases: Insights, Advances, and Challenges
Authors: Nii-Trebi Nicholas Israel
Published: February 2017

Infectious diseases are a significant burden on public health and economic stability of societies all over the world. They have for centuries been among the leading causes of death and disability and presented growing challenges to health security and human progress. The threat posed by infectious diseases is further deepened by the continued emergence of new, unrecognized, and old infectious disease epidemics of global impact. Over the past three and half decades at least 30 new infectious agents affecting humans have emerged, most of which are zoonotic and their origins have been shown to correlate significantly with socioeconomic, environmental, and ecological factors. As these factors continue to increase, putting people in increased contact with the disease causing pathogens, there is concern that infectious diseases may continue to present a formidable challenge. Constant awareness and pursuance of effective strategies for controlling infectious diseases and disease emergence thus remain crucial. This review presents current updates on emerging and neglected infectious diseases and highlights the scope, dynamics, and advances in infectious disease management with particular focus on WHO top priority emerging infectious diseases (EIDs) and neglected tropical infectious diseases.
Stowage Plan Based Slot Optimal Allocation in Rail-Water Container Terminal
Authors: Li Yanjing , Zhu Xiaoning , Wang Li , Chen Xi
Published: February 2017

To obtain an efficient and reasonable solution for slot allocation in rail-water container terminals, this paper develops storage optimal allocation model 1 to improve the yard space utilization, which is solved by a heuristic algorithm based on Tabu search. Model 2 is then built to reduce the relocation movements. A concept of fall-down problem in shunting operation plan is thus proposed to solve model 2. Models 1 and 2 are tested with numerical experiments. The results show that the yard space utilization increases by 50% approximately compared to the strategy of one train piling onto a fixed area called a subblock. Meanwhile the number of container relocation movements is less than five when using the fall-down problem strategy. Accordingly, the models and algorithms developed in this paper are effective to improve the yard space utilization and reduce the number of container relocation movements.
Relevance of the Physicochemical Properties of Calcined Quail Eggshell (CaO) as a Catalyst for Biodiesel Production
Authors: Marques Correia Leandro , Cecilia Juan Antonio , Rodríguez-Castellón Enrique , Cavalcante Célio Loureiro , Vieira Rodrigo Silveira
Published: February 2017

The CaO solid derived from natural quail eggshell was calcined and employed as catalyst to produce biodiesel via transesterification of sunflower oil. The natural quail eggshell was calcined at 900°C for 3 h, in order to modify the calcium carbonate present in its structure in CaO, the activity phase of the catalyst. Both precursor and catalyst were characterized using Hammett indicators method, X-ray fluorescence (XRF), X-ray diffraction (XRD), thermogravimetric analysis (TG/DTG), CO2temperature-programmed desorption (CO2-TPD), X-ray photoelectronic spectroscopy (XPS), Fourier infrared spectroscopy (FTIR), scanning electron microscopy (SEM), N2adsorption-desorption at −196°C, and distribution particle size. The maximum biodiesel production was of 99.00 ± 0.02 wt.% obtained in the following transesterification reaction conditions:XMR(sunflower oil/methanol molar ratio of 1 : 10.5 mol : mol),XCAT(catalyst loading of 2 wt.%),XTIME(reaction time of 2 h), stirring rate of 1000 rpm, and temperature of 60°C.
Chattering-Free Sliding-Mode Control for Electromechanical Actuator with Backlash Nonlinearity
Authors: Ma Dongqi , Lin Hui , Li Bingqiang
Published: February 2017

Considering the backlash nonlinearity and parameter time-varying characteristics in electromechanical actuators, a chattering-free sliding-mode control strategy is proposed in this paper to regulate the rudder angle and suppress unknown external disturbances. Different from most existing backlash compensation methods, a special continuous function is addressed to approximate the backlash nonlinear dead-zone model. Regarding the approximation error, unmodeled dynamics, and unknown external disturbances as a disturbance-like term, a strict feedback nonlinear model is established. Based on this nonlinear model, a chattering-free nonsingular terminal sliding-mode controller is proposed to achieve the rudder angle tracking with a chattering elimination and tracking dynamic performance improvement. A Lyapunov-based proof ensures the asymptotic stability and finite-time convergence of the closed-loop system. Experimental results have verified the effectiveness of the proposed method.
Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements with 82Rb PET
Authors: Ocneanu Adrian F. , deKemp Robert A. , Renaud Jennifer M. , Adler Andy , Beanlands Rob S. B. , Klein Ran
Published: February 2017

Purpose. Myocardial blood flow (MBF) quantification with Rb82 positron emission tomography (PET) is gaining clinical adoption, but improvements in precision are desired. This study aims to identify analysis variants producing the most repeatable MBF measures. Methods. 12 volunteers underwent same-day test-retest rest and dipyridamole stress imaging with dynamic Rb82 PET, from which MBF was quantified using 1-tissue-compartment kinetic model variants: (1) blood-pool versus uptake region sampled input function (Blood/Uptake-ROI), (2) dual spillover correction (SOC-On/Off), (3) right blood correction (RBC-On/Off), (4) arterial blood transit delay (Delay-On/Off), and (5) distribution volume (DV) constraint (Global/Regional-DV). Repeatability of MBF, stress/rest myocardial flow reserve (MFR), and stress/rest MBF difference (ΔMBF) was assessed using nonparametric reproducibility coefficients (RPCnp = 1.45 × interquartile range). Results. MBF using SOC-On, RVBC-Off, Blood-ROI, Global-DV, and Delay-Off was most repeatable for combined rest and stress: RPCnp = 0.21 mL/min/g (15.8%). Corresponding MFR and ΔMBF RPCnp were 0.42 (20.2%) and 0.24 mL/min/g (23.5%). MBF repeatability improved with SOC-On at stress (p<0.001) and tended to improve with RBC-Off at both rest and stress (p<0.08). DV and ROI did not significantly influence repeatability. The Delay-On model was overdetermined and did not reliably converge. Conclusion. MBF and MFR test-retest repeatability were the best with dual spillover correction, left atrium blood input function, and global DV.
Low-Grade Appendiceal Mucinous Neoplasm Presenting as an Adnexal Mass
Authors: Panagopoulos P. , Tsokaki T. , Misiakos E. , Domi V. , Christodoulaki C. , Sioutis D. , Papantoniou N.
Published: February 2017

Appendiceal tumors are rare, late diagnosed neoplasms that may not be differentiated from adnexal masses even by advanced imaging methods and other diagnostic procedures. They may be asymptomatic and remain undiagnosed until surgery. We report a case of an 80-year-old postmenopausal woman presenting with a pelvic mass and a history of weight loss. The patient underwent laparotomy which revealed an appendiceal mucocele, for which she received a full oncological procedure. The histology report showed a low-grade appendiceal mucinous neoplasm, and the patient underwent six cycles of chemotherapy. Appendiceal tumors should be kept in mind in patients with adnexal mass.
Rosemary Extracts Upregulate Nrf2, Sestrin2, and MRP2 Protein Level in Human Hepatoma HepG2 Cells
Authors: Tong Xiao-pei , Ma Yan-xia , Quan Dan-ni , Zhang Ling , Yan Miao , Fan Xin-rong
Published: February 2017

In the past few decades, the incidence of liver cancer has been rapidly rising across the world. Rosemary is known to possess antioxidant activity and is used as natural antioxidant food preservative. It is proposed to have anticancer activity in treating different tumor models. In this study, we try to explore the impact of rosemary extracts on upregulating the level of Nrf2 and Nrf2‐regulatory proteins, Sestrin2 and MRP2 in HepG2 cells, and to speculate its potential mechanism. The anticancer activity of rosemary extract, including its polyphenolic diterpenes carnosic acid and carnosol, was evaluated to understand the potential effect on HepG2 cells. Rosemary extract, carnosic acid, and carnosol induced the expression of Sestrin2 and MRP2 associate with enhancement of Nrf2 protein level in HepG2 cells, in which carnosic acid showed most obvious effect. Although the activation pathway of Nrf2/ARE was not exactly assessed, it can be assumed that the enhancement of expression of Sestrin2 and MRP2 may result from upregulation of Nrf2.
Multiaxial Cycle Deformation and Low-Cycle Fatigue Behavior of Mild Carbon Steel and Related Welded-Metal Specimen
Authors: Qu Weilian , Zhao Ernian , Zhou Qiang
Published: February 2017

The low-cycle fatigue experiments of mild carbon Q235B steel and its related welded-metal specimens are performed under uniaxial, in-phase, and 90° out-of-phase loading conditions. Significant additional cyclic hardening for 90° out-of-phase loading conditions is observed for both base metal and its related weldment. Besides, welding process produces extra additional hardening under the same loading conditions compared with the base metal. Multiaxial low-cycle fatigue strength under 90° out-of-phase loading conditions is significantly reduced for both base-metal and welded-metal specimens. The weldment has lower fatigue life than the base metal under the given loading conditions, and the fatigue life reduction of weldment increases with the increasing strain amplitude. The KBM, FS, and MKBM critical plane parameters are evaluated for the fatigue data obtained. The FS and MKBM parameters are found to show better correlation with fatigue lives for both base-metal and welded-metal specimens.
Demographics and Clinical Features of Postresuscitation Comorbidities in Long-Term Survivors of Out-of-Hospital Cardiac Arrest: A National Follow-Up Study
Authors: Su Chih-Pei , Wu Jr-Hau , Yang Mei-Chueh , Liao Ching-Hui , Hsu Hsiu-Ying , Chang Chin-Fu , Lan Shou-Jen , Chu Chiao-Lee , Lin Yan-Ren
Published: February 2017

The outcome of patients suffering from out-of-hospital cardiac arrest (OHCA) is very poor, and postresuscitation comorbidities increase long-term mortality. This study aims to analyze new-onset postresuscitation comorbidities in patients who survived from OHCA for over one year. The Taiwan National Health Insurance (NHI) Database was used in this study. Study and comparison groups were created to analyze the risk of suffering from new-onset postresuscitation comorbidities from 2011 to 2012 (until December 31, 2013). The study group included 1,346 long-term OHCA survivors; the comparison group consisted of 4,038 matched non-OHCA patients. Demographics, patient characteristics, and risk of suffering comorbidities (using Cox proportional hazards models) were analyzed. We found that urinary tract infections (n=225, 16.72%), pneumonia (n=206, 15.30%), septicemia (n=184, 13.67%), heart failure (n=111, 8.25%) gastrointestinal hemorrhage (n=108, 8.02%), epilepsy or recurrent seizures (n=98, 7.28%), and chronic kidney disease (n=62, 4.61%) were the most common comorbidities. Furthermore, OHCA survivors were at much higher risk (than comparison patients) of experiencing epilepsy or recurrent seizures (HR = 20.83; 95% CI: 12.24–35.43), septicemia (HR = 8.98; 95% CI: 6.84–11.79), pneumonia (HR = 5.82; 95% CI: 4.66–7.26), and heart failure (HR = 4.88; 95% CI: 3.65–6.53). Most importantly, most comorbidities occurred within the first half year after OHCA.
Meta-Analysis of the Risk of Subsequent Mood Episodes in Bipolar Disorder
Authors: Radua Joaquim , Grunze Heinz , Amann Benedikt L.
Published: February 2017

Background: Reported relapse and recurrence rates in bipolar disorder (BD) differ significantly between studies. Most data originate from highly selective patients participating in sponsored randomized controlled trials with narrow inclusion criteria. To estimate the true risk of a subsequent mood episode (SME) under real-world conditions, we conducted a meta-analysis of rates of SME as reported in naturalistic BD studies. Methods: PubMed, ScienceDirect, Scopus, and Web of Knowledge were searched until July 2015. Studies reporting the time until the emergence of an SME, from which individual data or Kaplan-Meier plots with censors marked could be retrieved, were included. Results: Twelve studies comprising 5,837 patients met the inclusion criteria. The median time to an SME in adults after an index episode was 1.44 years. The risk of an SME was 44% during the first year. Not having a SME during this first year lowered this risk to 19% in the second year. The risk was higher in bipolar II disorder (BD-II) than in bipolar I disorder (BD-I; HR = 1.5). In BD-I, the risk of a subsequent manic, mixed, or depressive mood episode was higher after an index episode of the same polarity (HR = 1.89-5.14). The overall risk of an SME was higher in patients with persisting subsyndromal symptoms (HR = 2.17). Conclusions: The data from this study provide a more reliable estimate of the risk of an SME in BD in real-world settings. Further research into the longitudinal course of BD-II is warranted to confirm its role as a risk factor for SME.
Conditioning Immune and Endocrine Parameters in Humans: A Systematic Review
Authors: Tekampe Judith , van Middendorp Henriët , Meeuwis Stefanie H. , van Leusden Jelle W.R. , Pacheco-López Gustavo , Hermus Ad R.M.M. , Evers Andrea W.M.
Published: February 2017

Background: Conditioned pharmacological effects may provide relevant clinical opportunities to improve treatment for patients with a variety of conditions. The aim of this systematic review was to create an overview of studies in this field of research and to investigate whether specific characteristics of the study design make for successful conditioning. Methods: The protocol of this review was registered in Prospero (PROSPERO 2015: CRD42015024148). A systematic literature search was conducted in the databases PubMed, Embase, and PsychInfo. Studies were included if they were placebo-controlled trials in humans in which the effects of a pharmacological agent on immune or endocrine outcomes (e.g., interleukin-2 and cortisol) were conditioned, using a specific conditioned stimulus. The risk of bias of each study was assessed using the Cochrane risk-of-bias tool. Results: The final selection included 16 studies. Overall, those studies indicate that conditioning of immunosuppression, conditioning of allergic responses, and conditioning of insulin and glycemic responses is possible. Regarding immunostimulants, antiallergic effects, and cortisol conditioning, the preliminary results are promising, but additional studies are needed. Conclusions: This systematic review shows classical conditioning of immune and endocrine responses for various pharmaceutical substances. The studies reviewed here indicate that the number of acquisition and evocation sessions, and characteristics of the unconditioned and conditioned stimuli, are important determinants of the effectiveness of pharmacological conditioning on immune and endocrine parameters. In the future, conditioned pharmacological effects may be used clinically as adjunct therapy in various patient populations.
Reviving Research on Medication Attitudes for Improving Pharmacotherapy: Focusing on Adherence
Authors: De las Cuevas Carlos , de Leon Jose
Published: February 2017

There is little current interest in research into patients' attitudes toward medications. In the 1960s, psychiatric researchers including Uhlenhuth, Rickels and Covi focused on this area, but this research topic needs to be revived in the 21st century. The Health Belief Model may hold potential for doing this. This model was initially developed by 2 health psychologists, Rosenstock and Becker, to explain why patients did not follow medical interventions. The application of this model to study medication adherence in psychiatric outpatients has provided multiple findings including the conclusions that adherence is associated with: (1) the balance between internal and external health control beliefs, (2) psychological reactance, (3) patients' attitudes toward prescribed drug treatment in general and (4) the balance between the necessity of taking medications versus the concerns derived from adverse drug reactions (ADRs). Poor adherence is associated with several cognitive styles of patients, including: (1) high internal and external health control beliefs (patients who feel that their health is controlled both by external factors and their own beliefs), (2) higher psychological reactance, (3) pharmacophobia (present in 1/6 patients) and (4) skepticism about medications (a high concern for ADRs and a low belief in the necessity of taking medications). All of these findings suggest that shared decision-making is particularly important in fostering adherence in psychiatric patients. Two wider applications of this article can be made: (1) opening psychiatry to advances in clinical psychology and (2) expanding studies on attitudes toward medications to other medical disciplines.