bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of COVID-19 Vaccine Communication, Acceptance, and Practices (CO-VIN-CAP) on Vaccine Hesitancy in an Indian Setting: Protocol for a Cross-sectional Study (Preprint)
Authors: Surapaneni Krishna Mohan , Kaur Mahima , Kaur Ritika , Grover Ashoo , Joshi Ashish
Published: April 2021

BACKGROUND

COVID-19 vaccines are considered to be a key to limiting and eliminating the infectious disease. However, the success of the vaccination program will rely on the rates of vaccine acceptance among the population.

OBJECTIVE

This study aims to examine the factors that influence vaccine hesitancy and vaccine acceptance, and to explore the unintended consequences of COVID-19 infections. The study will further explore the association between sociodemographic characteristics; health status; COVID-19–related knowledge, attitude, and practices; and its influence on vaccine hesitancy and acceptance among individuals living in urban and rural settings of Chennai, Tamil Nadu in the southern state of India.

METHODS

A cross-sectional study will be conducted between January 2021 and January 2023. A sample of approximately 25,000 individuals will be recruited and enrolled using a nonprobability complete enumeration sampling method from 11 selected urban and rural settings of Chennai. The data will be collected at one time point by administering the questionnaire to the eligible study participants. The collected data will be used to assess the rates of vaccine acceptance; hesitancy; and knowledge, attitudes, practices, and beliefs regarding COVID-19 and COVID-19 vaccines. Lastly, the study questionnaire will be used to assess the unintended consequences of COVID-19 infection.

RESULTS

A pilot of 2500 individuals has been conducted to pretest the survey questionnaire. The data collection was initiated on March 1, 2021, and the initial results are planned for publication by June 2021. Descriptive analysis of the gathered data will be performed using SAS v9.1, and reporting of the results will be done at 95% CIs and P=.049. The study will help explore the burden of vaccine acceptance and hesitancy among individuals living in urban and rural settings of Chennai. Further, it will help to examine the variables that influence vaccine acceptance and hesitancy. Lastly, the findings will help to design and develop a user-centered informatics platform that can deliver multimedia-driven health education modules tailored to facilitate vaccine uptake in varied settings.

CONCLUSIONS

The proposed study will help in understanding the rate and determinants of COVID-19 vaccine acceptance and hesitancy among the population of Chennai. The findings of the study would further facilitate the development of a multifaceted intervention to enhance vaccine acceptance among the population.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/29733
Витамин С при критических состояниях: от эксперимента к клинике (часть 2)
Authors: Chuklin S.M. , Chuklin S.S.
Published: April 2021

Витамин С (аскорбиновая кислота) играет важную физиологическую роль в многочисленных метаболических функциях. Он также является кофактором в синтезе важных веществ, в частности катехоламинов и вазопрессина. Снижение уровня аскорбиновой кислоты отмечено при различных заболеваниях и часто сопровождает тяжелое состояние больного. Целью этой статьи является обзор современных представлений о применении высоких доз витамина С при критических состояниях у хирургических больных. Для поиска литературных источников использовалась база Medline на платформе Pubmed по ключевым словам: витамин С, сепсис, шок, травма, ожоги.
Длительный электрокардиографический мониторинг в кардиохирургическом стационаре: современные взгляды и опыт применения телемониторинговой системы после стентирования коронарных артерий
Authors: Dziuba D.O. , Syvoraksha O.O. , Tchaikovsky I.A. , Khavryuchenko O.V. , Solovyov V.V. , Loskutov O.A.
Published: April 2021

Актуальность. Заболевания сердечно-сосудистой системы в Украине занимают лидерские позиции. На сего­дняшний день постоянный мониторинг электрокардиограммы (ЭКГ) является рутинным исследованием у пациентов, которые госпитализируются в больницу с сердечно-сосудистой патологией. Цель: провести анализ опыта применения длительного электрокардиографического мониторинга у пациентов в раннем послеоперационном периоде стентирования коронарных артерий. Материалы и методы. В исследование были включены 24 пациента с ишемической болезнью сердца, которым было проведено стентирование коронарных артерий в плановом порядке. Всем пациентам после окончания оперативного вмешательства проводился длительный ЭКГ-мониторинг. Результаты. Среди пациентов, принимавших участие в нашем исследовании, у 17 % больных в раннем послеоперационном периоде отмечались единичные наджелудочковые экстрасистолы и у всех пациентов были зафиксированы эпизоды единичных желудочковых экстрасистол. Значимой дислокации сегмента ST не было зафиксировано ни у одного пациента. Выводы. На основе наблюдения за пациентами с сердечно-сосудистыми событиями в послеоперационном периоде показано, что использование круглосуточной автоматической записи ЭГК с помощью мобильных устройств улучшает возможности своевременной диагностики (включая ургентную) повторных событий. Сформулированы рекомендации о целесообразности ее использования в различных режимах для пациентов с разным течением болезни.
Клинические основы синдрома гипертонического криза на уровне первичного звена
Authors: Vásquez Abanto J.E. , Vásquez Abanto A.E. , Arellano Vásquez S.B.
Published: April 2021

Гипертонический криз представляет собой частое явление на уровне первичной медико-санитарной помощи. Одной из основных задач в диагностике и лечении гипертонического криза в экстренной медицине является дифференциация между гипертензивной ургентностью (неосложненным гипертоническим кризом) и неотложностью (осложненным гипертоническим кризом), основанная на наличии повреждения органа-мишени во втором случае. Адекватная стратификация, профилактика и регрессия повреждения, вызванного гипертоническим кризом, могут предотвратить появление новых долгосрочных событий. Состояния гипертензивной ургентности (неосложненного гипертонического криза) обычно не связаны с непосредственным риском для жизни, поэтому лечение может быть начато и даже завершено в амбулаторных условиях. Состояния гипертензивной неотложности (осложненного гипертонического криза) — это очень серьезные клинические ситуации, которые требуют госпитализации. При наличии тяжелой гипертонии у пациента, бессимптомной или с неспецифическими симптомами, следует предпринять осторожный терапевтический подход. При лечении состояний гипертензивной ургентности усилия медиков направлены как на снижение показателей артериального давления (как минимум 20 % от базовых показателей), так и на избегание внезапного и/или чрезмерного его снижения (необходимо сохранять зону пенумбры). Следовательно, быстродействующие препараты не следует использовать из-за риска возникновения ишемических событий. При состояниях гипертензивной неотложности выбор препарата должен быть индивидуальным, причем парентеральный путь его введения является наиболее распространенной формой. При отсутствии симптомов повреждения органов-мишеней большинство пациентов, вероятно, могут лечиться в амбулаторных условиях. Соблюдение четкой преемственности диагностико-терапевтических мероприятий на догоспитальном этапе и в стационаре является необходимым условием для реальной стабилизации данного состояния. Экстренные состояния, связанные с гипертоническим кризом, в Украине являются основными причинами обращения и/или вызова врача экстренной медицины (≈ 25–26 %). Гипертонический криз, первичное проявление или осложнение ранее диагностированной артериальной гипертензии, чаще всего может иметь место в виде резкого повышения артериального давления ≥ 180/120 мм рт.ст. (хотя клиника гипертонического криза иногда наблюдается и при меньших цифрах). Методы поиска литературы: база данных Scopus, Web of Science, MedLine, CyberLeninka, РИНЦ.
Гармонизация личности и здоровье человека в современном мире
Authors: Semydotska Zh.D. , Neffa M.Yu.
Published: April 2021

В условиях углубления противоречий между технократическим и духовным развитием человечества все настойчивее заявляет о себе необходимость духовного оздоровления. На пути к духовному оздоровлению возникает необходимость переосмысления места и роли человека в мироздании. Врачевание духовности — валеологическая парадигма XXI века. Духовность тесно взаимодействует с так называемым физическим вакуумом, с одной стороны, и с физическими структурами личности — с другой. Признавая духовно-физическую структуру личности, официальная медицина стремится восстановить только физическое здоровье, пренебрегая его духовной константой. Научные доказательства существования единой энергосистемы мироздания уже появились в форме экспериментально обоснованной теории физического вакуума и торсионных полей. Если мы хотим адекватно понять фундаментальные основы здоровья, болезни и развития личности, непременно нужно учитывать духовный аспект бытия. Энергия мысли напрямую управляет здоровьем, стимулируя его, или, наоборот, вызывает болезнь. Мысли человека — основной носитель информации, в которой заключен энергетический потенциал. Объяснить энергетические процессы в организме законами классической физики не представляется возможным. Это область квантовой физики. Преобладание разума над материей — квантовая реальность. Некоторые положения квантовой физики постулирует квантовая биология. В частности, это касается корпускулярно-волнового дуализма элементарных биологических объектов и вероятности как категории, относящейся к квантовой сущности биологических объектов. Энергетические процессы составляют основу психической деятельности человека, а их законы описывают механизмы его мышления и сознания. Имеется взаимосвязь между энергетическими процессами и физиологией тела, взаимосвязь между веществом и энергией. Таким образом, сознание, энергия мысли управляют здоровьем, стимулируя его или, наоборот, вызывая болезнь. Духовный человек поднимается выше генетической судьбы. Эпигенетика изучает скрытые влияния на гены, оказываемые множеством источников, включая и мысли, и убеждения. Сила мысли меняет генетический код человека. Нужно хотеть перемен в своем мышлении и сознании. Мы своим сознанием влияем на процессы оздоровления. Сила мысли и слова играет большую роль в гармонизации личности и сохранении здоровья человека.
Обращение главного редактора
Authors: Ivanov D.D.
Published: April 2021

No abstract
Стандарты медицинской помощи при диабете — 2021
Authors: Authors No
Published: April 2021

No abstract
Уроки COVID-19 для медицинской практики. Метиленовый синий — инновация, проверенная временем
Authors: Ivanov D.D.
Published: April 2021

Значение метиленового синего (МС) в лечении метгемоглобинемии, малярии и инфекций мочевыводящих путей (ИМП) хорошо известно. Антимикробный, противовоспалительный и антиоксидантный эффекты МС были продемонстрированы в различных исследованиях in vitro и in vivo. Необходимость найти лекарство от COVID-19 привлекла внимание исследователей и практических врачей во всем мире к МС. Обзор включает различный опыт использования МС, в том числе у пациентов, получавших МС во время эпидемии COVID-19 с профилактической целью, а также собственный опыт по этой теме. МС широко применяется как краситель в различных областях биологии — в диагностических процедурах и лечении различных заболеваний, включая отравления цианидом и угарным газом, и считается нетоксичным. Эффективность МС при лечении пациентов с множественными небольшими камнями в почках, особенно с инфицированными камнями, и предупреждение образования новых камней были продемонстрированы в 5-летнем исследовании. Кроме того, благодаря противогрибковому потенциалу и антимикробному эффекту МС уменьшает симптомы ИМП, улучшает качество жизни и предотвращает рецидивы заболевания. Запатентованный комплекс МС с экстрактом листьев шалфея и экстрактом плодов клюквы крупноплодной (Пембина-Блю®) продемонстрировал значительное уменьшение боли, спазмов у больных циститом. Принимая во внимание ограниченное количество доступных методов лечения ИМП и одновременное увеличение резистентности к препаратам, необходимость поиска новых безопасных и эффективных методов лечения ИМП чрезвычайно актуальна. Учитывая то, что МС является одобренным FDA соединением, уже используется для решения различных терапевтических задач, а также благодаря отдельным антиоксидантным, противогрибковым, антибактериальным и противовоспалительным механизмам, которые приведены в данном обзоре, МС можно рассматривать как многообещающее лекарство в будущем.
Tingkat Erosi pada Plot Model Arsitektur Pohon Attims (Eucalyptus deglupta), Corner (Arenga pinnata), dan Rauh (Arthocarpus teysmanii)
Authors: Naharuddin Naharuddin
Published: April 2021

Tree architecture models and the composition of vegetation types affected surface runoff and erosion rates due to vegetation density and various other morphological and ecological characteristic components. This research purpose was to measure and compare the level of erosion in 3 tree architectural models. The research used the  path plots method.  The sample pathway was made by cut off contour lines. To measure the erosion rate that occured at the tree architecture model, erosion measuring plots were used in three tree architecture models, namely Attims (Eucalyptus deglupta), Corner (Arenga pinnata), and Rauh (Arthocarpus teysmanii). The results showed that the dominant tree architecture model was the Rauh, Attims, and Corner models. The erosion level which occurred in the three tree architectural models showed that the Attims Eucalyptus deglupta model and Corner Arenga pinnata models were more effective in controlling erosion by 233.55 g/ha/year and 293.10 g/ha/year with rainfall of 493.55 mm compared to Rauh Arthocarpus teysmanii type. The correlation analysis  between rainfall and the erosion rate at the three tree architecture models were 80% (very strong) for Attims model, 89% (very strong) for Corner model and 90% (very strong) for Rauh model. To control the erosion the Attims and Corner models are highly recommended as alternatives for rehabilitating the critical land.
Kontribusi Industri Bambu di Kabupaten Gunungkidul bagi Sumber Penghidupan Para Petani dan Pengrajin
Authors: Utomo Marcellinus Mandira Budi
Published: April 2021

The bamboo industry has a role in the rural economy as a source of livelihood. This research has examined the contribution of bamboo as a raw material for farmers and as a bamboo product for artisan, from the perspective of direct use and income. Through a case study approach to the kitchen equipment industry in Rongkop and durable bamboo in Patuk, a value chain research framework was carried out. Field observations, semi-structured interviews with 40 respondents, and focus group discussions were conducted to obtain primary data, and supported by secondary data from government documents. An analysis of expenditure-income accompanied by a descriptive qualitative analysis is used to explain the practices of these two industries and determine the economic contribution of the bamboo industry to each bamboo farmer and artisan in each chain. The products produced by each actor are allocated more for trade than for domestic use. The economic contribution for bamboo farmers in the durable bamboo chain and kitchen utensils to monthly income above the poverty line ranges between 7,7% - 13,5% and 6,4% - 8,9%, respectively. The economic contribution for artisan in durable bamboo chain and kitchen utensils chain to monthly income above the poverty line ranged between 13,2% -104% and 152% -472% respectively. Only kitchen utensil artisans make their activities in these two chains as the main work, while the other actors do not because the income from their businesses is still incidental.
Study on Refusal Strategies and Implication to English Teaching
Authors: Xibo Tian
Published: April 2021

This study makes an analysis of the refusal strategies of 30 native speakers of English (NS) and 50 Chinese EFL learners (NNS). It implicates that the latter adopts more strategies than the former when making a refusal in general. Both groups adopts more indirect strategies than direct strategies, and the order and frequency of semantic formulas in each situation were different in different situations. So in English teaching, teachers should focus on developing the learners' ability to overcome obstacles in communicative interactions and to become strategically competent
Mappings and decompositions of pairwise continuity on (i, j)-almost Lindelöf and (i, j)-weakly Lindelöf spaces
Authors: Salleh Zabidin , Kiliçman Adem
Published: April 2021

The purpose of this paper is to study the eect of mappings and some decompositions of pairwise continuity on (i, j)-almost Lindelöf spaces and (i, j)-weakly Lindelöf spaces. The main results are that an (i, j)-continuous image of an (i, j)-almost Lindelöf space is (i, j)-almost Lindelof and a pairwise almost continuous image of an (i, j)-weakly Lindelöf space is (i, j)-weakly Lindelöf. We also show that (i, j)-almost Lindelöf, pairwise almost Lindelöf, (i, j)-weakly Lindelöf and pairwise weakly Lindelöf properties are bitopological properties.
On the hereditary character of certain spectral properties and some applications
Authors: Carpintero Carlos Rafael , Rosas Rodríguez Ennis Rafael , García Mojica Orlando J. , Sanabria José Eduardo , Malaver Andrés
Published: April 2021

In this paper we study the behavior of certain spectral properties of an operator T on a proper closed and T-invariant subspace W ⊆ X such that Tn (X) ⊆ W, for some n ≥ 1, where T ∈ L(X) and X is an infinite-dimensional complex Banach space. We prove that for these subspaces a large number of spectral properties are transmitted from T to its restriction on W and vice-versa. As consequence of our results, we give conditions for which semiFredholm spectral properties, as well as Weyl type theorems, are equivalent for two given operators. Additionally, we give conditions under which an operator acting on a subspace can be extended on the entire space preserving the Weyl type theorems. In particular, we give some applications of these results for integral operators acting on certain functions spaces.
On degree of approximation of Fourier series of functions in Besov space using Nörlund mean
Authors: Padhy Birupakhya Prasad , Mishra Anwesha , Misra U. K.
Published: April 2021

In the present article, we have established a result on degree of approximation of function in the Besov space by (N; rn)- mean of  Trigonometric Fourier series
Prefacio
Authors: Internacional Geofísica
Published: April 2021

-
“Imbecilization” in the disinformation society: what can information literacy do about it?
Authors: Goulart Righetto Guilherme , Muriel-Torrado Enrique , Vieira Vitorino Elizete
Published: April 2021

El artículo analiza algunos puntos sobre el estado actual de la desinformación en los procesos de información, principalmente en el contexto mediático. La globalización y su constante movimiento, de carácter socialmente asimétrico y separatista, genera discrepancias colectivas y abre caminos a lo que se denomina imbecilización colectiva. En esta coyuntura, el fenómeno ampliamente abierto de la desinformación en la sociedad resulta en una manipulación y distorsión excesivas de la información. Por tanto, esta discusión presenta, a través de un relevamiento bibliográfico, la urgencia del desarrollo de la alfabetización informacional –cuyo supuesto consiste en el aprendizaje a lo largo de la vida– orientada a la disfunción informativa presente en la comunidad. Dicha alfabetización se denota como una forma de remediación y no como la erradicación absoluta del problema, ya que es fundamental preservar el pensamiento crítico y autocrítico para reducir y controlar la calidad de la información consumida y compartida. Los esfuerzos para combatir la llamada “imbecilización” y disfunción informativa deben darse en diferentes ámbitos de la vida social, involucrando la fusión multidisciplinar de tecnología, educación, cultura, economía y política.
Gut Extracts of Rhynchophorus ferrugineus Larvae Olivier Affecting Bacterial Dental Caries
Authors: Sewify G.H. , Hamada H.M. , Mustafa Z.A. , Alhadrami Hani A.
Published: April 2021

In vitro study was conducted to explore antibacterial properties of the larval gut extracts of Rhynchophorus ferrugineus (Red Palm Weevil) Oliver. Larval gut extracts were tested against salivary bacteria causing dental carries using the agar well diffusion method. The gut extracts significantly affected the growth of both Klebsiella spp. and Streptococcus viridans. The two bacterial species revealed significant differences in their sensitivity to the extract. The extract efficacy depended upon the concentration and time of exposure. When using 100%concentration of the extract, the mean of inhibition zones for S. viridans and Klebsiella spp. at 24 h after treatment were 1.61 mm and 2.50 mm, respectively. At 48 h post-treatment, the mean of inhibition zones for S. viridans and Klebsiella spp. were 1.96 mm and 2.66 mm. After 72 hours, the means zones were 2.28 mm and 2.91 mm, respectively. Electron microscopic examinations showed morphological changes of the outer membrane of bacteria with a noticeable damage as a result of exposure to the gut extract. The results suggest potential use of these extracts against dental caries bacteria.
Cultivation of Oyster Mushroom (Pleurotus ostreatus) from Agro-waste and Dry Leaf Litter in used Plastic Bottles: Community Waste Management Model targeting Stubble and Dry leaf burning
Authors: Kaur Sandeep , Bansal Himanshi , Hundal Bahaar , Arora Bhavya , Kaur Navneet , Sharma Nikita , Sharma Vandana
Published: April 2021

In recent years, solid waste management has developed from early approaches of burning or dumping to reuse, recycle, regain, and retain various alternative technologies. The present study aims at developing an effective community waste management model with a solution to multiple issues. It aims to provide an alternative to widespread stubble burning, burning dry leaf litter and promoting plastic reuse. The present novel technology involved the cultivation of Oyster Mushroom (Pleurotus ostreatus) in used plastic bottles to convert agricultural and urban waste into a highly nutritional end product. In this direction, the effect of different wheat straw and dry leaves’ ratios was assessed on the spawn run time, primordial formation, final harvesting time, mean yield per plastic bottle, and the % biological efficiency per gram of the substrate. Both the combinations of L30:WS70 and L50:WS50 represented ideal options for using the two waste substrates to cultivate the mushroom species. This model will help recycle agro-waste and serve as an effective method of generating nutritious food for fighting food security while decreasing the plastic load and trash thrown for disposal.
Expression of Programmed Cell Death 1 (PD-1) as a Marker of T-Cell Exhaustion and Its Correlation with Interleukin-10 Serum Level in Patients with COVID-19
Authors: Ibrahim Dalia M. , Mahmoud Fatma M. , Zaki Wafaa K. , Hamza Amr H. , ElSheshtawy Nadia M.
Published: April 2021

Coronavirus disease 2019 (COVID-19), which is a major global concern, is characterized by a progressive disease pattern involving diverse host immune responses. Programmed cell death marker-1(PD-1) expression, a critical checkpoint for T cell exhaustion, can be modulated by interleukin-10, which also mediates apoptotic T cell cytopenia. We aimed to measure the level of PD-1 expression and to investigate its correlation with IL-10 serum levels in modulating T cell effector function, correlating the results with the level of severity of the disease. This study involved 40 patients with COVID-19 and 20 healthy controls. Using flow cytometry, the expression of PD-1 was determined on CD8+ T lymphocytes and CD4+ T lymphocytes. ELISA was used to determine the levels of IL-10 in the serum. We found a remarkable decrease in T cell counts with functionally exhausted surviving T cells in the patient groups, especially in patients with severe disease. PD-1 expression increased significantly in CD4+, CD8+, and total T cells, showing a higher expression in CD8+ T cells. The patient groups had significantly higher serum IL-10 levels than the control group. The ROC analysis demonstrated the predictive role of IL-10 levels in disease severity (65% sensitivity, 80% specificity, and AUC = 0.806). IL-10 serum levels and PD-1 expression in total T cells were positively correlated, suggesting that IL-10 participates in T cell exhaustion.
Important Things Internists Should Know about Sodium-Glucose Co-Transporter 2 Inhibitors
Authors: Oleynick Christopher , Motazedian Pouya , Prosperi-Porta Graeme
Published: April 2021

ABSTRACTSodium-glucose co-transporter 2 (SGLT-2) inhibitors are a relatively new class of medications available in Canada used in the treatment of type 2 diabetes mellitus (T2DM). There is an abundance of emerging literature that these drugs are not only effective in the treatment of T2DM but also offer robust clinical benefits for renal disease, cardiovascular disease, and congestive heart failure. Despite the clinical benefits, SGLT-2 inhibitors may be underutilized as some physicians are unfamiliar with the medications or are concerned about their side-effect profile. Given the high prevalence of T2DM and the above comorbidities frequently encountered within Internal Medicine, it is important for internists to be familiar with SGLT-2 inhibitors. This is a short article encapsulating important aspects about these medications that we believe internists should know.
RÉSUMÉLes inhibiteurs du cotransporteur sodium-glucose de type 2 (SGLT-2) sont une classe relativement nouvelle de médicaments offerts au Canada et utilisés dans le traitement du diabète de type 2 (DT2). Une profusion de nouvelles études montre que ces médicaments sont non seulement efficaces dans le traitement du DT2, mais qu’ils offrent également de solides avantages cliniques pour les maladies rénales, les maladies cardiovasculaires et l’insuffisance cardiaque congestive. Malgré ces avantages cliniques, les inhibiteurs du SGLT-2 sont peut-être sous-utilisés, car certains médecins ne connaissent pas ces médicaments ou s’inquiètent de leur profil d’effets secondaires. Étant donné la forte prévalence du DT2 et les affections comorbides susmentionnées fréquemment rencontrées en médecine interne, il est important que les internistes connaissent bien les inhibiteurs du SGLT-2. Voici un court article qui résume les aspects importants de ces médicaments que les internistes devraient connaître.
What to Do When They’re Eating for Two? A Case of Catheter-Directed Thrombolysis for Submassive Pulmonary Embolism in Pregnancy
Authors: Radford James Michael
Published: April 2021

ABSTRACTA 33-year-old G7P0 female at 8 weeks gestation presented to the emergency department (ED) following a syncopal episode. She complained of chest pain and dyspnea, and had hemodynamic instability, which responded to intravenous fluids. Continued fluid resuscitation, supplemental oxygen, as well as therapeutic dose low molecular weight heparin (LMWH) were administered in the ED. Computed tomography (CT) pulmonary angiogram confirmed saddle pulmonary embolism (PE). After 12 h of continued chest pain and high oxygen requirements, a decision was made to use catheter-directed thrombolysis (CDT) involving alteplase with manual thrombus maceration in bilateral pulmonary arteries. There were no immediate hemorrhagic complications and follow-up fetal ultrasound demonstrated a normal viable intrauterine pregnancy. She clinically improved and was discharged on LMWH. Cesarean section was scheduled, and the patient delivered a healthy term infant at 37 weeks gestation without complications. Our case demonstrates that CDT may be a safe and effective treatment for submassive PE in pregnancy.
RÉSUMÉUne femme âgée de 33 ans et enceinte de huit semaines (G7P0) se présente aux urgences à la suite d’un épisode syncopal. Elle se plaint de douleurs thoraciques et de dyspnée et présente une instabilité hémodynamique qui répond aux solutés intraveineux. Une réanimation liquidienne continue, une oxygénothérapie ainsi qu’une dose thérapeutique d’héparine de faible poids moléculaire sont administrées aux urgences. L’angiographie pulmonaire par tomodensitométrie confirme une embolie pulmonaire en selle. Après 12 heures de douleurs thoraciques continues et de besoins élevés en oxygène, on décide d’utiliser la thrombolyse dirigée par cathéter (TDC) à l’aide de l’altéplase avec macération manuelle du thrombus dans les artères pulmonaires bilatérales. Il n’y a pas eu de complications hémorragiques immédiates et le suivi échographique du fœtus a démontré une grossesse intra utérine normale et viable. Son état clinique s’est amélioré et elle a obtenu son congé sous héparine de faible poids moléculaire. Une césarienne a été planifiée et la patiente a accouché d’un enfant à terme et en bonne santé à 37 semaines de grossesse, sans complications. Notre cas démontre que la TDC peut être un traitement sûr et efficace de l’embolie pulmonaire submassive en cours de grossesse.
Casebook of a Community Internist: Fun with Finals
Authors: Baillie Hector M
Published: April 2021

The words 'Final Examination' when applied to medical training seems inappropriate.  Learning is lifelong, but there have to be milestones where judgement happens.   In particular, an Oral Exam can invoke all sorts of excitement.
Postoperative Delirium
Authors: Wong Camilla L. , Von Maltzahn Maia
Published: April 2021

There is strong evidence to support prevention of postoperative delirium through comprehensive geriatric assessment and multicomponent nonpharmacologic interventions. Risk assessment must be accompanied by communication of the risk to the patient, caregivers, and perioperative interdisciplinary team to engage all in evidence-based prevention interventions. However, once postoperative delirium has developed, efforts should be focused on prevention of short- and long-term adverse effects.
 
RÉSUMÉDes données probantes solides appuient la prévention du délire postopératoire en recourant à une évaluation gériatrique complète et à des interventions non pharmacologiques à plusieurs composantes. L’évaluation des risques doit s’accompagner d’une communication du risque au patient, aux soignants et à l’équipe interdisciplinaire périopératoire afin que tous participent aux interventions de prévention fondées sur des données probantes. Toutefois, une fois que le délire postopératoire s’est installé, les efforts doivent être axés sur la prévention des effets indésirables à court et à long terme.
Manifestações orofaciais associadas aos diferentes tipos de anemias
Authors: Pires Alessandra Laís Pinho Valente , Santos Deivson Henrique dos , Nascimento Deivid Rodrigues , Santos Júnior José Carlos Costa dos , Amorim Marília de Matos , Almeida Cristiane Brandão Santos , Aguiar Marcela Beatriz Moreira
Published: April 2021

Introduction: Anemias correspond to hematological disorders that can present in the oral cavity and face. Objective: To review the literature on the main types of anemic disorders and their orofacial manifestations, considering the aspects of interest to dentists. Methodology: This is a literature review, in which articles were selected in Portuguese and English, indexed in the Scielo, Medline/Pubmed and Lilacs databases with the descriptors: Anemia, Oral Manifestations, Jaw Abnormalities and their correspondents in Portuguese language. Literature review: Anemic disorders associated with orofacial signs and symptoms include mainly Iron-Deficiency, Megaloblastic, Fanconis, Sickle Cell, Thalassemia and Aplastic Anemia. The manifestations vary from burning and painful symptoms in the tongue, pallor of lips and mucosa, stomatitis, atrophic glossitis, angular cheilitis, susceptibility to candidiasis and peri-odontal disease. Also, dental changes, hyposalivation, malocclusion, osteomyelitis of the jaw, paraesthesia of the mental nerve and orofacial pain are included. Conclusion: These manifestations can be the first signs of the presence of anemia, which gives the dentist an important role in early diagnosis and proper management of dental treatment.
Avaliação e manejo da ansiedade e fobia odontológica: a psicologia na formação do cirurgião-dentista
Authors: Gomes Guilherme Borsato , Stabile Cecília Luiz Pereira , Ximenes Vanessa Santiago
Published: April 2021

Dental fear and anxiety arise from several factors, among them, exposure to previous traumatic experiences with needles, injections and instruments that can cause discomfort. Anxious patients tend to reschedule appointments, avoid treatments and are only available for visits at the dentist when painful symptoms appear, so delayed treatment tends to be more invasive and cause even more emotional damage to the patient, consequently aggravate this feeling and, in turn, create a vicious cycle in which avoiding treatment only makes the oral health condition even worse. It is up to professionals of Dentistry to identify anxiety in patients and make use of resources to manage this anxiety in order to enable an effective dental treatment with less emotional damage to the patient. The aim of this study is to evaluate, by means of a integrative literature review, the importance of the study of Psychology by the dental professional and to expose the techniques for coping with dental anxiety, based on scientific evidences.
Metaloproteinases da matriz: papel no desenvolvimento das lesões periapicais e modulação após tratamento endodôntico
Authors: De Paula e Silva Francisco Wanderley Garcia , Arnez Maya Fernanda Manfrin , De Almeida-Júnior Luciano Aparecido , De Carvalho Marcio Santos , Petille Renato , De Queiroz Alexandra Mussolino , Bezerra da Silva Léa Assed
Published: April 2021

Introduction: Apical periodontitis represents a local immune response directed against the progression of microorganisms from the dental pulp to the apical foramen and periapical tissues, which results in bone and dental resorption. The aim of this review is to describe the expression of this group of proteases in apical periodontitis and its modulation during the periapical healing phase following root canal treatment. Literature review: The pathogenesis of apical periodontitis involves degradation of several extracellular matrix components. Matrix metalloproteinases (MMPs) are expressed in response to specific stimuli by resident cells of connective tissue during tissue remodeling and by inflammatory cells that arrive into the surrounding tissues during inflammatory events. MMPs have been reported in apical periodontitis, either experimentally induced or obtained from humans and there is evidence that these enzymes show diff erent expression patterns in granulomas and periapical cysts. Root canal therapy is important for the reduction of periapical inflammation as well as the synthesis of MMPs, especially when using a calcium hydroxide-based dressing. Conclusion: Apical periodontitis show high expression of matrix metalloproteinases and root canal treatment results in less expression of MMPs when compared to untreated apical periodontitis.
O uso de desenhos como técnica projetiva em odontopediatria
Authors: Moreira Pinto Larissa , Serpa Stéffani , Baschirotto Custódio Natália
Published: April 2021

The dental environment can be considered a stressor for children, and can trigger unwanted behaviors. Pediatric Dentistry is a specialty that requires professionals to know preventive measures and restorative skills to perform dental treatment in children or adolescents. In addition, it is especially important that the professional is concerned with the child’s feelings and reactions, allowing the pediatric dentist to identify situations that may generate stress for the patient during the care, and manage the presented behaviors. Recent studies have measured children’s reactions and feelings during dental treatments using projective techniques. Given the importance of drawing to identify children’s emotions, the objective of this study was to search the literature about the use of drawings as a projective technique in Pediatric Dentistry. Therefore, projective techniques, with an emphasis on drawing, have proved to be an effective instrument to be used in clinical practice to better understand the reactions presented by children during dental care and their relationship with dentists. Thus, avoiding unexpected situations in the office and allowing greater chances of obtaining a positive return from the patient.
Cirurgia do periápice para remoção de lesões granulomatosas: relato de caso
Authors: De Jesus Sidinéia Feitoza , Meneses Yasmim Santos , De-Sá Rafaela Cardoso , Elias Vanessa Valente , De Carvalho Marcio Santos , De Queiroz Alexandra Mussolino , De Paula e Silva Francisco Wanderley Garcia , Sousa-Neto Manoel Damião
Published: April 2021

Periapical granuloma is a histological term that refers to the formation of a mass of granulomatous tissue around the apex of a tooth resulting from inflammation and necrosis of the pulp tissue. It consists of an infiltrate of inflammatory cells such as macrophages, plasmocytes and lymphocytes, as well as fibroblasts, collagen fibers and capillaries. Periapical surgery is an alternative for preserving the tooth in the oral cavity in cases where periapical inflammation is persistent even after treatment of root canals. The objective of this study was to report a clinical case in which the surgical technique was used to remove granulomatous lesions from a patient, female, with a history of recurrent periapical abscess without painful symptomatology in the region of the anterior 11,12 and 13 teeth. The histopathological exam demonstrated the presence of a granulomatous tissue with intense inflammatory infiltrate mixed, permeated with lymphocytes and high number of plasmocytes, confirming the diagnosis of periapical granuloma. The treatment was considered successful since the patient remained asymptomatic and there was incorporation of the inorganic bovine bone graft and initiation of bone neoformation in the periapical region.
Alveólise decorrente de traumatismo dentário: relato de caso
Authors: Lima Ribeiro Maria Arianna , Nogueira Borges da Costa Kamila , Machado Bezerra Tacíria , Coelho Ferreira Meire
Published: April 2021

The alveolysis is a pathological condition classified as partial or total dehiscence (the root exposure is partial or total and involves the marginal bone) and apical fenestration (the root exposure doesn’t involve the marginal bone). Usually occurs by vestibular and in the anterior region of the maxilla. It’s commonly associated with chronic infections provoked by dental caries and dental trauma. This study aims to report a clinical alveolysis case in a previous traumatized deciduous tooth of a 4 years old child. Clinical examination noticed aveolysis apical fenestration type associated to partial dehiscence (tooth 51) and presence of mobility. In the radiographic examination it was found thickening of the pericementary space and external root resorption. The indicated treatment was extraction of the affected tooth and the use of maintainer of space. Based on the reported case, it is concluded that early care and the control of traumatized and decayed teeth are essential for the prevention of alveolysis.
Avaliação de soluções antifúngicas de guanidina para resina base de dentadura: um estudo in vitro
Authors: Gama Maria Eduarda Rodrigues , Leitune Vicente Castelo Branco , Garcia Isadora Martini , Rodrigues Stéfani Becker , Collares Fabrício Mezzomo
Published: April 2021

Background: The purposes of this study were: (1) to formulate polyhexamethylene guanidine hydrochloride (PHMGH) solutions at different concentrations; (2) to evaluate their antifungal activity against a mature biofilm of Candida albicans on acrylic resins; (3) to evaluate possible effects on acrylic resins flexural strength and surface roughness. Methods: PHMGH solutions were formulated with distilled water and 0.125, 0.250, or 0.5 wt.% of PHMGH. One group without PHMGH was used as control. For antifungal activity analysis, acrylic resin specimens were contaminated with C. albicans. Specimens were immersed in PHMGH solutions or distilled water for 5 or 10 min. Ultimate flexural strength and surface roughness of acrylic resins were evaluated. Results: All PHMGH solutions at 5 or 10 min showed antifungal activity compared to the control group (p
Acompanhamento de três anos de restaurações do tipo bulk-fill flow em dentes posteriores: ensaio clínico controlado randomizado duplo-cego
Authors: Kury Matheus , Goulart Marcelo , Thomé Thaís , Conceição Ewerton Nocchi , Coelho-de-Souza Fábio Hermann , Cavalli Vanessa , Erhardt Maria Carolina Guilherme
Published: April 2021

Objective: This randomized clinical trial evaluated the behavior of restorations with flowable bulk-fill resin composite in posterior teeth three years after the restorative treatment. Methods: Seventeen patients (12 women, 5 men, age 23-59) were selected to have at least two failing amalgam or resin restorations replaced and/or to have a carious lesion restored. The cavities were randomly allocated to receive either the flowable bulk-fill composite Surefil SDR Flow occlusally covered with the conventional nano-hybrid composite Esthet-X HD (bulk and body technique) or filled exclusively with Esthet-X HD placed in 2 mm increments (incremental technique). A two-step etch-and-rinse adhesive was applied in all cavities. Thirty-four Class I or II restorations were performed in posterior teeth (n=17) during baseline. After 03 years, modified USPHS and FDI criteria were used to evaluate the restorations. Data were subjected to Mann-Whitney statistical analysis (p0.05). No restoration failures were observed over time. Conclusion: After 03 years of clinical service, all restorations using a flowable bulk-fill composite in posterior teeth showed an acceptable performance. Clinical Significance: The overall quality of posterior restorations made with the bulk and body technique was similar to that of restorations made with a nano-hybrid composite incrementally placed.
Rutas teóricas para estudiar ciudades neoliberales: Un acercamiento desde su territorialización
Authors: Jiménez-Corrales Andrés
Published: April 2021

El neoliberalismo tiene más de 70 años de evolución en el mundo; en este tiempo, ha desplegado sus postulados en diversas formas de territorialización. Las ciudades representan una escala privilegiada para la reproducción del neoliberalismo, debido a su relevancia geoeconómica en el capitalismo. En este artículo, con la delineación de rutas teóricas para el abordaje de la ciudad neoliberal desde su territorialización, se desarrolló a partir de una revisión documental de bibliografía especializada, junto con la experiencia investigativa del autor en relación con el tema; para mostrar elementos generales para entender la ciudad neoliberal en diálogo con el uso de ejemplos concretos. Finalmente, se concluye que la territorialización de la ciudad neoliberal conduce al establecimiento de territorios exclusivos y excluyentes.
Evaluación de competencias en lectura crítica y pensamiento científico en matemáticas y estadística en las pruebas Saber 11 y Saber Pro 2016-2017 en dos programas de ingeniería
Authors: Restrepo Betancur María Ruby , Giraldo Arcila Sindy Viviana
Published: April 2021

The objective of this work is to evaluate the competences in critical reading and cientific mathematical and statistical thinking of students in the last semester of Financial Engineering and Commercial Engineering. In this context, the evaluation is considered as learning guiding process, through it, it is possible to obtain the necessary information to identify what was learned, what was not learned and take assertive decisions can be made in the teaching process and learning. Therefore, in this research, the results achieved by the students in the Saber 11 Tests applied by ICFES, and subsequently, the results obtained by the same students in the Saber Pro Tests, belonging to the programs in mention of the Universidad Libre. This research is a study of evaluative design, nonexperimental, of explanatory character that uses a methodology of complementarity between the qualitative and quantitative methods. The SPSS software was used as an instrument for data processing, through which ...
Integridad intestinal en pollos de engorde alimentados con ensilaje de ramio (boehmeria nivea) mezclado con afrecho de yuca (manihot esculenta)
Authors: Betancourt Vásquez Jaime Andrés , Guerrero Núñez María Camila , Estrada Núñez Luz Andrea
Published: April 2021

Bird’s intestinal health is determinant because of its connotation on disease control, but also because it is the source of utilization of nutrients that results in successful production. Conventional raw material used for the fabrication of concentrate is expensive and has low availability, for these reasons, food alternatives with indigenous resources such as forage, have been sought out. In this way, B. nivea stands out as an alternative for feeding birds. The goal of this study was to determine the effect of using silage from B. nivea mixed with cassava bran (Manihot esculenta) on the intestinal integrity of fed broilers. 60 male broilers of the Ross 308 line were located in 12 pens, to each of which a completely randomized experimental treatment design was given. The treatments consisted in two types of diets provided to the birds, a control group that was only given concentrate and another group, that additional to the concentrate used in the control group, was given B. nivea ...
False Endometrial Thickening in Postmenopausal Patients Using Anticoagulants or Antiplatelets Agents
Authors: Ata Nahit , Kulhan Nur
Published: April 2021

Objective There is no report that anticoagulant or antiplatelet use may
lead to abnormal endometrial sonographic findings. This retrospective
study reports our first results associated with endometrial sampling in
asymptomatic postmenopausal women using anticoagulants or antiplatelet.
Materials methods A total of 268 postmenopausal patients who applied to
our gynecology outpatient clinic for any reasons except postmenopausal
bleeding were included in the study. Patients were divided into three
groups according to using drug status: first healty control group (HCG),
second anticoagulants agents group (ACG), and third antiplatelet agents
group (APG). The effects of anticoagulant and antiplatelet agents on
endometrial thickness were compared with histopathological findings.
Results The mean endometrial thickness was significantly greater in
group ACG (5.2 mm) and APG (4.1 m) than in group HCG (3.3 mm). No
significant differences were found in the mean endometrial thickness
between groups HCG and APG. However, it is noteworthy that the average
endomeric thickness in the ACG group is more than the other two groups
and this is statistically significant (p < 0.05). Conclusion
If the thickness of the endometrium was > 4 mm. endometrial
sampling may be recommended in in asymptomatic postmenopausal women
using anticoagulants or antiplatelet agents. Key words: Anticoagulants,
antiplatelets, biopsy, endometrial thickness, menopause, ultrasonography