bluuebunny/crossref_metadata_2025 huggingface dataset:
An investigation of exhaust smoke dispersion for a generic frigate by numerical analysis and experiment
Authors: Dobrucali Erinc , Ergin Selma
Published: November 2017

The effects of efflux velocity, operational conditions, stack geometry, and buoyancy on the exhaust dispersion for a generic frigate are investigated numerically. The conservation of energy, momentum, mass, species, and turbulence equations have been solved using the finite volume method. It is found that the exhaust smoke dispersion is affected by the efflux velocity, operational conditions, buoyancy, and turbulence, as well as the geometry of the stack. The momentum of the exhaust gases and the plume height increase as the velocity ratio increases. The results for the slow ahead operation condition show that the buoyancy effect is the strongest, and the plume height is minimum for this case. The exhaust temperatures and velocity values for the full ahead operation are found to be the highest. However, the plume height for this case is not maximum. This may be attributed to the high turbulence levels for this case. It is found that the effect of stack geometry on the exhaust smoke dispersion is not significant for the geometries considered in the study. The computations are validated with the flow visualization tests carried out in a wind tunnel. The agreement between the numerical and experimental results is found to be good.
Generating tensions: A multilevel, process analysis of organizational change
Authors: Panayiotou Alexia , Putnam Linda L , Kassinis George
Published: November 2017

Working within a Bakhtinian perspective of relational dialectical tensions, this study seeks to elaborate on current organizational change theories through a rich set of qualitative data collected on an Internet start-up that revolutionized the music industry. Following the company for 12 years, we focused on the tensions arising during the company’s development and on the responses to these tensions. Our results indicate that with a process model, tensions and decisions develop in a reflexive relationship, which shows that change happens, not in spite of unintended consequences, but because of the unintended consequences of the decisions enacted. We show that change is not always the result of deliberate intentions, conscious choices, and purposeful actions of individuals, but rather as an ongoing process that evolves through countervailing dynamics at multiple organizational levels. Tensions and responses to them are pivotal to this process of changing and should be analyzed as directional markers for future oppositional struggles. Consistent with the Bakhtinian position, we find that change occurs within the interplay of tensions as actors live out struggles and decisions in the midst of organizing.
Draft Once; Deploy Everywhere? Contextualizing Digital Law and Brazil’s Marco Civil da Internet
Authors: Hoskins Guy T.
Published: November 2017

On Congressional approval in 2014, Brazil’s charter of civil rights for the Internet, the Marco Civil da Internet, was widely acclaimed as a template for national Internet policy elsewhere in the world. This was the result of a phenomenon I dub “draft once; deploy everywhere,” a pervasive belief in the universality of Internet law. This presumption underpins multiple charters of Internet rights drafted by digital rights organizations and policymakers. By showing how the Marco Civil was bitterly contested by blocks of powerful actors, the role played by Brazil’s recent history of dictatorship as well as its status at the margins of the global digital economy, I problematize the Marco Civil’s status as a global blueprint. This matters because without proper contextualization, the effective transfer of Internet law across national jurisdictions will be harder to realize, and their democratic virtues will prove more elusive.
The Effects of Behavioral Parent Training With Adjunctive Social Skills Training for a Preadolescent Girl With ADHD and Borderline Personality Features
Authors: Babinski Dara E. , Mills Sara L. , Bansal Pevitr S.
Published: November 2017

Girls with attention deficit hyperactivity disorder (ADHD) are at high risk of a range of social–emotional difficulties, including peer rejection, suicide attempts, and borderline personality disorder (BPD), which are associated with serious, long-term impairment and have not emerged as clearly in samples of boys with ADHD. BPD is a particularly concerning long-term outcome of ADHD in girls, given the high risk for suicidality and long-lasting relationship difficulties. Very little research has focused on treatment for the interpersonal impairments of girls with ADHD, or on addressing risk for developing BPD. This case study describes the use of behavioral parent training (BPT) with adjunctive social skills training (SST) to address the social–emotional difficulties of a 9-year-old girl, “Violet,” who was diagnosed with ADHD Combined Presentation and was being treated with medication for anxiety. Violet presented with many social difficulties, including low self-esteem, emotional dysregulation, and unstable relationships, which were conceptualized as borderline personality features (BPF). Treatment was associated with improvements in parent functioning, including reductions in caregiver strain and inconsistent discipline, as well as improvements in child functioning, including reductions in ADHD symptoms, a range of impairments, and BPF. This case study illustrates the benefit of a brief psychosocial intervention in reducing multiple indices of interpersonal impairment, including BPF, for a girl with ADHD.
Medications for Sleep Schedule Adjustments in Athletes
Authors: Baird Matthew B. , Asif Irfan M.
Published: November 2017

Context:

Sleep schedule adjustments are common requirements of modern-day athletes. Many nonpharmacologic and pharmacologic strategies exist to facilitate circadian rhythm shifts to maximize alertness and performance during competition. This review summarizes the evidence for commonly used pharmacologic agents and presents recommendations for the sports medicine provider.

Evidence Acquisition:

MEDLINE searches were performed using the following keywords: sleep aids, circadian rhythm adjustment, athletes and sleep, caffeine and sports, melatonin and athletes, and sleep aids and sports. Pertinent articles were extracted and discussed.

Study Design:

Clinical review.

Level of Evidence:

Level 2.

Results:

There are very few available studies investigating pharmacologic sleep aids in athletes. Data from studies involving shift workers and airline personnel are more abundant and were used to formulate recommendations and conclusions.

Conclusion:

Melatonin, caffeine, and nonbenzodiazepine sleep aids have a role in facilitating sleep schedule changes in athletes and maximizing sports performance through sleep enhancement.
Medication use and falls: Applying Beers criteria to medication review in Parkinson’s disease
Authors: Yusupov Eleanor , Chen Davina , Krishnamachari Bhuma
Published: November 2017

Objectives:

Our goal was to assess the association between potentially inappropriate medication use and risk of falls in the Parkinson’s disease population.

Methods:

This was a retrospective cohort study conducted at an outpatient Parkinson’s Disease Treatment Center. Individuals 65 years of age or older, diagnosed with Parkinson’s disease who attended at least three visits in 2015 for physical, occupational therapy, or physician’s visits were included in the study. Electronic medical records were utilized to perform chart reviews, and medications were analyzed to identify prescription medications, combination preparations, over-the-counter medications, and dietary supplements. The goal of this study was to test the following hypothesis: elderly individuals with Parkinson’s disease who take multiple potentially inappropriate medications are more likely to experience a fall compared to elderly individuals with Parkinson’s disease who do not take multiple potentially inappropriate medications.

Results:

A higher mean number of prescription medications were associated with falls in elderly Parkinson’s disease patients (6.53 vs 5.21, p < 0.01). Polypharmacy (taking five or more prescription and nonprescription medications) was not significantly associated with falls. Patients taking potentially inappropriate medications specifically contraindicated for those with a history of falls and fractures were more likely to report falls (p < 0.04). Analysis of the specific therapeutic medication categories demonstrated no significant differences between those who did and did not report falls.

Conclusion:

A future prospective study at Parkinson’s disease center should include an electronic medical record–based intervention to reduce the total number of medications, as well as to minimize the use of high-risk medications.
Comparison of structural magnetic resonance imaging findings between neuropsychiatric systemic lupus erythematosus and systemic lupus erythematosus patients: A systematic review and meta-analysis
Authors: Amin Omed , Kaul Arvind , Smith Toby O , Howe Franklyn A , Sofat Nidhi
Published: November 2017

Introduction:

Neuropsychiatric systemic lupus erythematosus is often clinically challenging to diagnose, treat and monitor. Although brain magnetic resonance imaging is frequently performed before lumbar puncture in neuropsychiatric systemic lupus erythematosus, it is not clear from the literature whether specific brain magnetic resonance imaging findings are associated with distinct clinical features of neuropsychiatric systemic lupus erythematosus.

Methods:

We conducted a systematic review and meta-analysis on published studies of neuropsychiatric systemic lupus erythematosus including brain magnetic resonance imaging and the 1999 American College of Rheumatology-defined clinical neuropsychiatric systemic lupus erythematosus syndromes to determine their relationship. Pooled prevalence and risk ratio for distinct neuropsychiatric systemic lupus erythematosus associations were determined with 95% confidence intervals.

Results:

Of 821 studies screened, 21 fulfilled inclusion criteria. A total of 818 participants were evaluated (91% female) with 1064 neuropsychiatric systemic lupus erythematosus episodes assessed. Neuropsychiatric systemic lupus erythematosus features included headache (24%), seizures (19%), cerebrovascular disease (18%), cognitive dysfunction (15%) and acute confusional state (14%). Normal magnetic resonance imaging was significant for anxiety disorder (risk ratio: 9.00; 95% confidence interval: 2.40, 33.79), autonomic disorder (risk ratio: 7.00; 95% confidence interval: 0.51, 96.06) and plexopathy (risk ratio: 5.00; 95% confidence interval: 0.81, 31.00). Highest risk ratio of neuropsychiatric systemic lupus erythematosus syndrome with abnormal magnetic resonance imaging was observed for cerebrovascular disease (risk ratio: 0.15; 95% confidence interval: 0.10, 0.24) and demyelination (risk ratio: 0.11; 95% confidence interval: 0.02, 0.72).

Conclusion:

Normal magnetic resonance imaging in neuropsychiatric systemic lupus erythematosus was the most significant correlate from our meta-analysis for psychological symptoms including anxiety and peripheral nerve features of autonomic disorder and plexopathy. The main abnormal brain magnetic resonance imaging correlates included cerebrovascular disease and demyelination. Brain magnetic resonance imaging correlates poorly with neuropsychiatric systemic lupus erythematosus features, and specific clinical symptoms should be the main determinants of performing magnetic resonance imaging rather than presence of neuropsychiatric systemic lupus erythematosus per se.
Risk factors and clinical outcomes of delirium in osteoporotic hip fractures
Authors: Kim Joon Yub , Yoo Jeong Hyun , Kim Eugene , Kwon Ki Bum , Han Byeong-Ryong , Cho Yongun , Park Jai Hyung
Published: November 2017

Purpose:

This study is performed to identify risk factors for delirium in osteoporotic hip fractures and to evaluate the hospitalization cost and clinical outcomes of delirium in osteoporotic hip.

Methods:

A total of 221 patients with osteoporotic hip fractures were assessed for eligibility between 2010 and 2014. Among them, 37 patients with delirium were allocated into the delirium group (group D) and 37 patients without delirium were allocated into the non-delirium group (group ND) by matching demographic factors. Risk factors such as time between admission and operation, body mass index, American Society of Anesthesiologists status, cognitive impairment, preoperative urinary catheter, electrolyte imbalance, preoperative hemoglobin, polymedication (medications > 5), pneumonia, anesthesia time, operation time, estimated blood loss, and total amount of transfusion were evaluated for correlation with incidence of delirium. The hospitalization cost was evaluated, and clinical outcomes such as readmission, mortality, and activity level at 1-year follow-up were evaluated.

Results:

In multivariate analysis, polymedication ( p = 0.028) and preoperative indwelling urinary catheter insertion status ( p = 0.007) were related to the incidence of delirium in patients with osteoporotic hip fractures. Group D showed a significantly higher hospitalization cost compared to group ND. However, delirium did not have a significant effect on length of hospital stay, readmission rate, postoperative 1-year mortality, and activity level.

Conclusions:

Polymedication and preoperative urinary catheter were related to perioperative delirium. In addition, delirium in osteoporotic hip fractures may not have a detrimental effect on clinical outcomes; however, hospitalization cost seemed to be increased due to delirium.
Radiographic Location Does Not Ensure a Precise Anatomic Location of the Femoral Fixation Site in Medial Patellofemoral Ligament Reconstruction
Authors: Sanchis-Alfonso Vicente , Ramírez-Fuentes Cristina , Montesinos-Berry Erik , Elía Isabel , Martí-Bonmatí Luis
Published: November 2017

Background:

A frequently used method to determine the anatomic femoral fixation point in the operating room during medial patellofemoral ligament (MPFL) reconstruction is the radiographic method. However, the ability of this radiological method to establish an anatomic femoral attachment point might not be as accurate as expected.

Purpose:

(1) To evaluate the accuracy of the radiological method to locate the anatomic femoral fixation point in MPFL reconstruction surgery and (2) to determine the factors influencing the predictability of this method to obtain this objective.

Study Design:

Cohort study (diagnosis); Level of evidence, 2.

Methods:

A total of 100 consecutive 3-dimensional computed tomography (3D CT) knee examinations were performed at 0° of extension in 87 patients treated for chronic lateral patellar instability. For each knee, 2 virtual 7 mm–diameter femoral tunnels were created: 1 using the adductor tubercle as a landmark (anatomic tunnel) and the other according to the radiological method described by Schöttle et al (radiographic tunnel). We measured the percentage of overlap between both tunnels. Moreover, of the 100 included knees, 10 were randomly selected for a variability study.

Results:

Considering an overlap area greater than 50% as reasonable, the radiographic method achieved this in only 38 of the 100 knees. Intrarater and interrater reliability were excellent. There was a trend for female patients with severe trochlear dysplasia to have less overlap. This model accounted for 64.2% of the initial variability in the data.

Conclusion:

An exact anatomic femoral tunnel placement could not be achieved with the radiographic method. Radiography provided only an approximation and should not be the sole basis for the femoral attachment location. Moreover, in female patients with severe trochlear dysplasia, the radiographic method was less accurate in determining the anatomic femoral fixation point, although differences were not statistically significant.
The impact of urban proximity, transport accessibility and policy on urban growth: A longitudinal analysis over five decades
Authors: Kasraian Dena , Maat Kees , van Wee Bert
Published: November 2017

Transport accessibility is assumed to be a main driver of urbanisation. Like many other metropolitan regions, the Randstad, the population and economic core of the Netherlands has experienced significant urbanisation, transport network expansion and spatial policies aimed to channel urban growth. This paper investigates the long-term relationships between the development of railway and motorway networks, urbanisation, and spatial policies, by using a panel dataset consisting of grid cells measured at six time points from 1960 to 2010. Generalised Estimating Equations analysis was applied to model the built-up area. Predictors include proximity to and accessibility by transport infrastructure, vicinity of urban areas, and spatial policies. Results indicate that road and rail accessibility alike, stably influenced urbanisation, but less than proximity to urban areas. Spatial policies played a significant role in channelling new urbanisation, while preserving the centrally located green and mainly rural area. Remarkably, the legacy of earlier policies is still significant despite shifts in predominant Dutch spatial policies. The findings are expected to be relevant for comparable poly-nuclear areas.
Time to revise our dialogue: how flat is the paediatric flatfoot?
Authors: Morrison Stewart C. , McClymont Juliet , Price Carina , Nester Chris
Published: November 2017

A recent systematic review of measures of foot development used the medial longitudinal arch profile as its primary indicator of development. A comparative analysis of existing studies was undertaken. This work confirmed changes with arch profile were age‐dependent, although the age at which foot development ceased remains unknown. This work also highlighted the abundance of clinical measures used in existing research and outlined the challenges with drawing consensus from available data. There is a clear need to move this debate forward and, to do so, it is essential that scientific and clinical communities unite. It is time to abandon ill‐defined measures of foot position, look beyond the medial longitudinal arch as a sole parameter of foot development and re‐focus our perspective(s) on the paediatric foot in order to make advances with clinical practice and research.
Testing the effectiveness of a motivational interviewing-based brief intervention for substance use as an adjunct to usual care in community-based AIDS service organizations: study protocol for a multisite randomized controlled trial
Authors: Garner Bryan R. , Gotham Heather J. , Tueller Stephen J. , Ball Elizabeth L. , Kaiser David , Stilen Patricia , Speck Kathryn , Vandersloot Denna , Rieckmann Traci R. , Chaple Michael , Martin Erika G. , Martino Steve
Published: November 2017

Background

In 2010, the first comprehensive National HIV/AIDS Strategy for the United States was released and included three goals: (1) reducing the number of people who become infected with HIV, (2) increasing access to care and improving health outcomes for people living with HIV, and (3) reducing HIV-related health disparities and health inequities. In 2013, as part of its effort to help address the National HIV/AIDS Strategy, the National Institute on Drug Abuse (NIDA) funded a type 2 effectiveness-implementation hybrid trial titled the Substance Abuse Treatment to HIV Care (SAT2HIV) Project. Aim 1 of the SAT2HIV Project tests the effectiveness of a motivational interviewing-based brief intervention (MIBI) for substance use as an adjunct to usual care within AIDS Service Organizations (ASOs) as part of its MIBI Experiment. Aim 2 of the SAT2HIV Project tests the effectiveness of implementation and sustainment facilitation (ISF) as an adjunct to the Addiction Technology Transfer Center (ATTC) model for training staff in motivational interviewing as part of its ISF Experiment. The current paper describes the study protocol for the MIBI Experiment.

Methods

As part of a multisite randomized controlled trial, individuals with comorbid HIV/AIDS and problematic substance use are randomized to receive either the ASOs’ usual care (control condition) or usual care plus a MIBI for substance use (experimental condition) delivered by trained ASO case-management staff. Primary outcome measures are reductions in days of primary substance use, number of substance-related problems, times engaging in risky behaviors, days of non-adherence to HIV medications, and increases in substance use treatment. As part of this paper, we describe the trial protocol in accordance with the Standard Protocol Items: Recommendations for Interventional Trials guidelines.

Discussion

If successfully able to implement MIBI as an effective adjunct to usual care, the current trial may have a significant impact on increasing the capacity of ASOs to address problematic substance use among individuals living with HIV/AIDS. Reducing the prevalence of problematic substance use among individuals living with HIV/AIDS within the United States may lead to significant improvements on key performance measures (i.e., the HIV Care Continuum and the 90-90-90 target).

Trial registration ClinicalTrials.gov: NCT02495402
The Effects of Practice-Based Training on Graduate Teaching Assistants’ Classroom Practices
Authors: Becker Erin A. , Easlon Erin J. , Potter Sarah C. , Guzman-Alvarez Alberto , Spear Jensen M. , Facciotti Marc T. , Igo Michele M. , Singer Mitchell , Pagliarulo Christopher
Published: November 2017

Evidence-based teaching is a highly complex skill, requiring repeated cycles of deliberate practice and feedback to master. Despite existing well-characterized frameworks for practice-based training in K–12 teacher education, the major principles of these frameworks have not yet been transferred to instructor development in higher educational contexts, including training of graduate teaching assistants (GTAs). We sought to determine whether a practice-based training program could help GTAs learn and use evidence-based teaching methods in their classrooms. We implemented a weekly training program for introductory biology GTAs that included structured drills of techniques selected to enhance student practice, logic development, and accountability and reduce apprehension. These elements were selected based on their previous characterization as dimensions of active learning. GTAs received regular performance feedback based on classroom observations. To quantify use of target techniques and levels of student participation, we collected and coded 160 h of video footage. We investigated the relationship between frequency of GTA implementation of target techniques and student exam scores; however, we observed no significant relationship. Although GTAs adopted and used many of the target techniques with high frequency, techniques that enforced student participation were not stably adopted, and their use was unresponsive to formal feedback. We also found that techniques discussed in training, but not practiced, were not used at quantifiable frequencies, further supporting the importance of practice-based training for influencing instructional practices.
Coherence-based time migration velocity analysis by the use of supergathers
Authors: Sakamori Momoe , Biloti Ricardo
Published: November 2017

Errors in the migration velocity field are perceived as moveouts in common-image gathers (CIGs). These moveouts depend on discrepancies in the velocity field as well as in the dip of the reflectors. We extend previous works into two main aspects. First, we found an accurate description of the residual moveout, considering the reflector dip, whereas only second-order approximations have been provided so far. Our formula for the moveout is exact, at the cost of being implicit. We evaluate an efficient numerical method to compute it accurately. Examples are provided to confirm that dipping angles far beyond those considered by previous approaches are reliable. Second, our moveout description is valid within a range of offsets and CIG positions, meaning that we can handle more than one CIG at once. In other words, instead of describing a moveout curve on a single CIG, we are able to compute a moveout surface across image gathers. From this larger volume of data, numerical experiments determine that more robust estimations are obtained for the velocity correction factors. Finally, the estimation of the best-fit parameters is carried out by a traditional coherence-based analysis, in which a modern derivative-free optimization method is used. We develop a set of numerical tests to validate the description of the residual moveouts, to compare our strategy with previous work from the literature, as well as to demonstrate that just a few image gathers are sufficient to stabilize the estimation of velocity correction factors. As a by-product, we obtained estimations of the reflector as well.
PDGFRα/PDGFRβ signaling balance modulates progenitor cell differentiation into white and beige adipocytes
Authors: Gao Zhanguo , Daquinag Alexes C. , Su Fei , Snyder Brad , Kolonin Mikhail G.
Published: November 2017

The relative abundance of thermogenic beige adipocytes and lipid-storing white adipocytes in adipose tissue underlie its metabolic activity. The roles of adipocyte progenitor cells, which express PDGFRα or PDGFRβ, in adipose tissue function have remained unclear. Here, by defining the developmental timing of PDGFRα and PDGFRβ expression in mouse subcutaneous and visceral adipose depots, we uncover depot specificity of pre-adipocyte delineation. We demonstrate that PDGFRα expression precedes PDGFRβ expression in all subcutaneous but in only a fraction of visceral adipose stromal cells. We show that high-fat diet feeding or thermoneutrality in early postnatal development can induce PDGFRβ+ lineage recruitment to generate white adipocytes. In contrast, the contribution of PDGFRβ+ lineage to beige adipocytes is minimal. We provide evidence that human adipose tissue also contains distinct progenitor populations differentiating into beige or white adipocytes, depending on PDGFRβ expression. Based on PDGFRα or PDGFRβ deletion and ectopic expression experiments, we conclude that the PDGFRα/PDGFRβ signaling balance determines progenitor commitment to beige (PDGFRα) or white (PDGFRβ) adipogenesis. Our study suggests that adipocyte lineage specification and metabolism can be modulated through PDGFR signaling.
A novel role for sox7 in Xenopus early primordial germ cell development: mining the PGC transcriptome
Authors: Butler Amanda M. , Owens Dawn A. , Wang Lingyu , King Mary Lou
Published: November 2017

Xenopus primordial germ cells (PGCs) are determined by the presence of maternally derived germ plasm. Germ plasm components both protect PGCs from somatic differentiation and begin a unique gene expression program. Segregation of the germline from the endodermal lineage occurs during gastrulation, and PGCs subsequently initiate zygotic transcription. However, the gene network(s) that operate to both preserve and promote germline differentiation are poorly understood. Here, we utilized RNA-sequencing analysis to comprehensively interrogate PGC and neighboring endoderm cell mRNAs after lineage segregation. We identified 1865 transcripts enriched in PGCs compared with endoderm cells. We next compared the PGC-enriched transcripts with previously identified maternal, vegetally enriched transcripts and found that ∼38% of maternal transcripts were enriched in PGCs, including sox7. PGC-directed sox7 knockdown and overexpression studies revealed an early requirement for sox7 in germ plasm localization, zygotic transcription and PGC number. We identified pou5f3.3 as the most highly expressed and enriched POU5F1 homolog in PGCs. We compared the Xenopus PGC transcriptome with human PGC transcripts and showed that 80% of genes are conserved, underscoring the potential usefulness of Xenopus for understanding human germline specification.
Drosophila embryonic type II neuroblasts: origin, temporal patterning, and contribution to the adult central complex
Authors: Walsh Kathleen T. , Doe Chris Q.
Published: November 2017

Drosophila neuroblasts are an excellent model for investigating how neuronal diversity is generated. Most brain neuroblasts generate a series of ganglion mother cells (GMCs) that each make two neurons (type I lineage), but 16 brain neuroblasts generate a series of intermediate neural progenitors (INPs) that each produce 4-6 GMCs and 8-12 neurons (type II lineage). Thus, type II lineages are similar to primate cortical lineages, and may serve as models for understanding cortical expansion. Yet the origin of type II neuroblasts remains mysterious: do they form in the embryo or larva? If they form in the embryo, do their progeny populate the adult central complex, as do the larval type II neuroblast progeny? Here, we present molecular and clonal data showing that all type II neuroblasts form in the embryo, produce INPs and express known temporal transcription factors. Embryonic type II neuroblasts and INPs undergo quiescence, and produce embryonic-born progeny that contribute to the adult central complex. Our results provide a foundation for investigating the development of the central complex, and tools for characterizing early-born neurons in central complex function.
The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway
Authors: Calpena Eduardo , López del Amo Víctor , Chakraborty Mouli , Llamusí Beatriz , Artero Rubén , Espinós Carmen , Galindo Máximo I.
Published: November 2017

Members of the Junctophilin (JPH) protein family have emerged as key actors in all excitable cells, with crucial implications for human pathophysiology. In mammals, this family consists of four members (JPH1-JPH4) that are differentially expressed throughout excitable cells. The analysis of knockout mice lacking JPH subtypes has demonstrated their essential contribution to physiological functions in skeletal and cardiac muscles and in neurons. Moreover, mutations in the human JPH2 gene are associated with hypertrophic and dilated cardiomyopathies; mutations in JPH3 are responsible for the neurodegenerative Huntington's disease-like-2 (HDL2), whereas JPH1 acts as a genetic modifier in Charcot–Marie–Tooth 2K peripheral neuropathy. Drosophila melanogaster has a single junctophilin (jp) gene, as is the case in all invertebrates, which might retain equivalent functions of the four homologous JPH genes present in mammalian genomes. Therefore, owing to the lack of putatively redundant genes, a jp Drosophila model could provide an excellent platform to model the Junctophilin-related diseases, to discover the ancestral functions of the JPH proteins and to reveal new pathways. By up- and downregulation of Jp in a tissue-specific manner in Drosophila, we show that altering its levels of expression produces a phenotypic spectrum characterized by muscular deficits, dilated cardiomyopathy and neuronal alterations. Importantly, our study has demonstrated that Jp modifies the neuronal degeneration in a Drosophila model of Huntington's disease, and it has allowed us to uncover an unsuspected functional relationship with the Notch pathway. Therefore, this Drosophila model has revealed new aspects of Junctophilin function that can be relevant for the disease mechanisms of their human counterparts.
TGF-β induces oncofetal fibronectin that, in turn, modulates TGF-β superfamily signaling in endothelial cells
Authors: Ventura Elisa , Weller Michael , Macnair Will , Eschbach Katja , Beisel Christian , Cordazzo Cinzia , Claassen Manfred , Zardi Luciano , Burghardt Isabel
Published: November 2017

Gene splicing profiles are frequently altered in cancer, and the splice variants of fibronectin (FN) that contain the extra-domains A (EDA) or B (EDB), referred to as EDA+FN or EDB+FN, are highly upregulated in tumor vasculature. Transforming growth factor β (TGF-β) signaling has been attributed a pivotal role in glioblastoma, with TGF-β promoting angiogenesis and vessel remodeling. By using immunohistochemistry staining, we observed that the oncofetal FN isoforms EDA+FN and EDB+FN are expressed in glioblastoma vasculature. Ex vivo single-cell gene expression profiling of tumors by using CD31 and α-smooth muscle actin (αSMA) as markers for endothelial cells, and pericytes and vascular smooth muscle cells (VSMCs), respectively, confirmed the predominant expression of FN, EDA+FN and EDB+FN in the vascular compartment of glioblastoma. Specifically, within the CD31-positive cell population, we identified a positive correlation between the expression of EDA+FN and EDB+FN, and of molecules associated with TGF-β signaling. Further, TGF-β induced EDA+FN and EDB+FN in human cerebral microvascular endothelial cells and glioblastoma-derived endothelial cells in a SMAD3- and SMAD4-dependent manner. In turn, we found that FN modulated TGF-β superfamily signaling in endothelial cells via the EDA and EDB, pointing towards a bidirectional influence of oncofetal FN and TGF-β superfamily signaling.
The Role of Ambidexterity in Managing Buyer–Supplier Relationships: The Toyota Case
Authors: Aoki Katsuki , Wilhelm Miriam
Published: November 2017

Most ambidexterity theories deal with managing exploration–exploitation trade-offs among business units within firms or between alliance partners, but these theories remain yet to be extended to the buyer-supplier relationship level. Through an in-depth case study of the Toyota Motor Corporation, we illustrate how buying firms can simultaneously achieve short-term and long-term benefits with their long-standing suppliers. Taking two inherently different activities as a starting point—mass production with its focus on exploitation and product development with its focus on exploration—we show that the deliberate use of ambiguity and explicitness can function as a countervailing mechanism against overemphasizing either exploration or exploitation. We also show that structural separation and structural integration are two organizational systems that can be used by buying firms to help suppliers realize ambidexterity in their operations. Finally, we argue that “requisite security” can help to motivate suppliers to address the paradoxical tensions deliberately created by buying firms.
Managing Influenza A virus on pig farms: diagnosis and prevention
Authors: Gotter Verena
Published: November 2017

Antimicrobial resistance is an important global problem of the 21st century, and managing it is a global challenge. Veterinary surgeons as well as human doctors have their role to play in reducing and refining the use of antimicrobials in their patients. The use of antimicrobials can be reduced by good management, optimising the environment, improving nutrition and using prophylaxis to reduce disease, and by the accurate identification of pathogens causing disease, followed by appropriate control measures. Both viral and bacterial pathogens may be responsible for porcine respiratory disease, therefore accurate diagnosis of infection with viral pathogens such as Influenza A virus, which should be controlled without the use of antimicrobials, is essential. For this it is important to use the appropriate diagnostic techniques, including consideration of clinical signs and pathological findings; taking the correct samples (e.g. broncho-alveolar lavage, blood samples, necropsy samples); sampling sufficient affected animals; and carrying out the appropriate diagnostic tests (e.g. polymerase chain reaction, serology).
Overview: boost nutrition and cut antibiotic use with additives
Authors: Murch Fay
Published: November 2017

Feeding the modern pig has moved on from just blending raw materials together to make a diet. Precision nutrition is the way we are moving forwards, but how do additives fit into this concept? Can we just add a long list of additives to cover all eventualities and improve gut health?
Stay on course
Authors: Clarke Jenni
Published: November 2017

Try Jenni Clarke's simple race and chase games to develop the concept of number while keeping children physically active. Use obstacle courses with pop up tunnels to increase the fun factor.
One big family
Authors: Rawstrone Annette
Published: November 2017

‘Blended families’ are becoming increasingly common with up to half of parents remarrying after five years of separating. Annette Rawstrone looks at the implications for the youngest family members.
In the abstract
Authors: Garner Lynne
Published: November 2017

Introduce modern art with Matisse's colourful paper cut The Snail and talk about techniques including paper cutting, ripping and crumpling. Collaborate to create ‘noise art’ linked to all the senses!
Festive greetings!
Authors: Hart Karen
Published: November 2017

Hand-made greetings cards are a fantastic way to get into the festive mood and explore ideas to do with ice and snow. They also encourage children to test their dexterity, particularly using their fine pincer grasp.
The analysis of synovial fluid in total knee arthroplasties with flexion instability
Authors: Hernandez N. M. , Taunton M. J. , Perry K. I. , Mara K. C. , Hanssen A. D. , Abdel M. P.
Published: November 2017

Aims

Patients with flexion instability after total knee arthroplasty (TKA) often present with a recurrent effusion, which may be a haemarthrosis. While the radiographic factors contributing to flexion instability have been elucidated, the clinical diagnosis remains challenging. Our aim, in this study, was to determine the mean white cell count and differential profile in pre-operative aspirations of synovial fluid in a consecutive series of patients undergoing revision TKA for flexion instability.

Patients and Methods

Between 2000 and 2010, 60 patients undergoing aseptic revision TKA for flexion instability were identified. The results of the pre-operative aspiration of synovial fluid were available for 53 patients (88%). These patients were 1:2 matched to 106 patients who underwent aseptic TKA for indications other than flexion instability. The mean age of the patients at revision TKA was 65 years (44 to 82) and 55% were women. The mean follow-up was 4.3 years (2 to 10.2).

Results

In the flexion instability group, the median total cell count was 312 cells/µL (interquartile range (IQR) 104 to 624), with a mean distribution of 45% macrophages (2% to 90%), 30% lymphocytes (1% to 69%), 18% neutrophils (0% to 80%), 0.5% eosinophils (0% to 6%) and 7% other cells (0% to 42%; mainly synovial cells). There was no significant difference in the median total cell count (p = 0.14) or mean distribution of macrophages (p = 0.42), lymphocytes (p = 0.38), neutrophils (p = 0.19) and eosinophils (p = 0.89) between the flexion instability and control groups. There was a significant difference in the percentage of bloody serosanguineous aspirations which was 58% in the flexion instability group and 18% in the control group (odds ratio = 6.5; p = 0.0001).

Conclusions

In the group of patients who underwent revision TKA for flexion instability, most had a mean cell count and differential similar to those who underwent revision for other aseptic indications. However, bloody serosanguineous aspirations were 6.5 times more common in those with flexion instability confirming that many of the recurrent effusions seen in this condition are haemarthroses. Cite this article: Bone Joint J 2017;99-B:1477–81.
Metabolic Effects of Bariatric Surgery
Authors: Sinclair Piriyah , Docherty Neil , le Roux Carel W
Published: November 2017

BACKGROUND

Obesity can be defined as a chronic subcortical brain disease, as there is an important neurophysiological component to its etiology based on changes in the functioning of those areas of the brain controlling food intake and reward. Extensive metabolic changes accompany bariatric surgery-based treatment of obesity. Consequently, the term “metabolic” surgery is being increasingly adopted in relation to the beneficial effects these procedures have on chronic diseases like type 2 diabetes.

CONTENT

In the present review, we focus on the key biochemical and physiological changes induced by metabolic surgery and highlight the beneficial effects accrued systemically with the use of an organ-based approach. Understanding the impact on and interactions between the gut, brain, adipose tissue, liver, muscle, pancreas, and kidney is key to understanding the sum of the metabolic effects of these operations.

Further mechanistic studies are essential to assess the true potential of metabolic surgery to treat metabolic comorbidities of obesity beyond type 2 diabetes. Approaches that may mitigate the metabolic side effects of surgery also require attention. Understanding the positive impact of metabolic surgery on metabolic health may result in a wider acceptance of this intervention as treatment for metabolic, comorbid conditions.
Media diversity in Portugal: political framework and current challenges
Authors: Baptista Carla , Silva Marisa Torres da
Published: November 2017

This article addresses the current “state of the art” in Portuguese media diversity policy, focusing on the social inclusiveness domain within public service media. The indicators assess regulatory and policy safeguards for community media, access to media by minorities, local and regional communities, women and people with disabilities, as well as the country’s media literacy environment. Although the majority of these in dicators have legal safeguards or benefit from specific policies, we concluded there is still considerable work to be done, particularly in the realms of media literacy and the representation of minority groups and women in the media. This article results from an on-going research, gathering data and literature review from the following projects: Media Pluralism Monitor (MPM) project, implemented by the Centre for Media Pluralism and Media Freedom (CMPF) at the European University Institute and funded by the European Commission; and DIVinTV - Public Television and Cultural Diversity in Portugal, funded by FCT.
Overlap coefficients based on Kullback-Leibler divergence: Exponential populations case
Authors: Dhaker Hamza , Ngom Papa , Mbodj Malick
Published: November 2017

This article is devoted to the study of overlap measures of densities of two exponential populations. Various Overlapping Coefficients, namely: Matusita’s measure ρ, Morisita’s measure λ and Weitzman’s measure ∆. A new overlap measure Λ based on Kullback-Leibler measure is proposed. The invariance property and a method of statistical inference of these coefficients also are presented. Taylor series approximation are used to construct confidence intervals for the overlap measures. The bias and mean square error properties of the estimators are studied through a simulation study.
Modeling search movements of an insect's front leg
Authors: Tóth Tibor I. , Berg Eva , Daun Silvia
Published: November 2017

Beside locomotion, search movements are another important type of motor activity of insects. They are very often performed by the front legs of the animals. They consist of cyclic stereotypical leg movements that can be modified by sensory signals. The details of the local organization of these movements have however not yet been studied. In this paper, we, using an appropriate variant of our existing one‐leg model, present a scheme of how these searching movements might be organized and performed on the level of local neuromuscular control networks. In the simulations with the model, we attempted to mimic the experimental results by Berg et al. (J. Exp. Biol. 216:1064–1074, 2013) in which an obstacle was put in the way of the search movements of the front leg for a very short while, and then the recovery to the usual search movements was observed and analyzed. Our simulation results suggest that the recruitment of the fast levator and depressor muscles play a crucial part in resuming the search movements after removal of the obstacle. The interplay between the levator and depressor, and the extensor and flexor local control networks can, according to the model, bring about a large variety of search movements upon removal of the obstacle. A number of these movements are comparable with those seen in the experiments.
Effect of some factors on championship results and performance in Hucul horses
Authors: Topczewska Jadwiga , Krupa Wanda
Published: November 2017

The objective of the study was to determine the effects of some factors on the breeding and performance championship results of Hucul horses. The study material were results of the national finals of the breeding and performance championships for Hucul horses held during 2009-2015. These included breeding champion, the Hucul path as well as the endurance-condition tests. The one-way ANOVA and GLM procedure (multivariate ANOVA with interaction effects) were employed to estimate the impact of the analysed variables on the results of the breeding and performance assessment. The current results were, for the Hucul path and endurance-condition tests, significantly lower than for 2013. Individuals that were held in the foothills and mountain areas attained significantly higher scores at the breeding and performance championships. Strong impacts of breeding environment on levels of inbreeding were only observed in cases where the scores in respect of horse movement were at walk (η2
p=0.13; P=0.04), trot (η2
p=0.17; P=0.003) and the results for Hucul path (η2
p=0.18, P=0.002). By far the strongest impact on the assessment for type (η2
p=0.36, P=0.000) and conformation (η2
p=0.32, P=0.006) was exercised by the interaction of age with male line and breeding environment, but in case of rating for movement at walk and trot, it was for the interaction of age with inbreeding and the breeding environment, namely η2
p=0.31, P=0.04; η2
p=0.33, P=0.01 respectively. Dependencies between components of assessment for Hucul horses were correlated at low and medium levels.
Some results on pseudo-Q algebras
Authors: Rezaei Akbar , Saeid Arsham Borumand , Walendziak Andrzej
Published: November 2017

The notions of a dual pseudo-Q algebra and a dual pseudo-QC algebra are introduced. The properties and characterizations of them are investigated. Conditions for a dual pseudo-Q algebra to be a dual pseudo-QC algebra are given. Commutative dual pseudo-QC algebras are considered. The interrelationships between dual pseudo-Q/QC algebras and other pseudo algebras are visualized in a diagram.
Application of Knitting Structure Textiles in Medical Areas
Authors: Zhang Xiaohui , Ma Pibo
Published: November 2017

There are many kinds of medical textiles, such as woven textiles, non-woven textiles, braided textiles and knitted textiles. Non-woven medical textiles constitute more than 60% of the total medical textiles used, but are almost disposable ordinary medical textiles. While knitted fabrics forms a small part of the medical textiles, but are greatly applied in high-tech medical textiles, containing artificial blood vessels, hernia patches, cardiac support devices, knitted medical expandable metallic stents and tendon scaffolds. Knitting structures, including weft knitting structure and warp knitting structure. The knitted textiles are popular for their loose structure, greater flexibility, higher porosity, more flexible structure and better forming technology. The present article will introduce some knitting structures and materials applied in the medical textiles in accordance with non-implantable, implantable, extra-corporeal textiles and healthcare and hygiene products.
Reproductive ecology of an invasive lineage 2 population of Asparagopsis taxiformis (Bonnemaisoniales, Rhodophyta) in the Alboran Sea (western Mediterranean Sea)
Authors: Zanolla Marianela , Carmona Raquel , Altamirano María
Published: November 2017

Can the reproductive traits of