bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular docking studies of Triphala with catalytic portion of HMG-CoA reductase enzyme
Authors: Rinthong Prasoborn , Pulbutr Pawitra , Mudjupa Chawannuch
Published: April 2023

Introduction: Triphala, consisting of three fruits, Phyllanthus emblica L. (Phyllanthaceae), Terminalia bellirica (Gaertn.) Roxb. (Combretaceae), and T. chebula Retz, is a well-recognized Ayurvedic herbal formulation, used for various therapeutic purposes, including the treatment of dyslipidemia. Inhibitory activity against 3‑hydroxy‑3‑methylglutaryl‑coenzyme A (HMG‑CoA) reductase, a rate-limiting enzyme in the endogenous cholesterol synthesis pathway, is an essential target for the management of hypercholesterolemia. This in silico study aimed to investigate the HMG-CoA reductase inhibitory activity of the phytochemical compounds derived from Triphala formulation by employing molecular docking analysis. Methods: Ten phytochemical constituents of Triphala formulation were selectively used for docking study by using the HMG-CoA reductase template (PDB: 1HWK). Docking analysis was performed using AutoDock 4.2. The candidates were ranked by the binding energy parameters. Results: From the docking studies, the phytochemical compounds with HMG-CoA reductase inhibition could be classified into 4 groups, including phytosterols, polyphenols, tannins, and flavonoids. Beta-sitosterol exhibited the highest binding affinity to HMG-CoA reductase with a binding energy of -7.75 kcal/mol. Conclusion: These 10 phytochemical compounds in Triphala potentially exert their cholesterol-lowering effects via inhibition against HMG-CoA reductase. Nonetheless, further in vitro and in vivo experiments should be conducted subsequently to confirm this finding.
In vitro and in silico investigation of garlic’s (Allium sativum) bioactivity against 15-lipoxygenase mediated inflammopathies
Authors: Khan Arman Mahmud , Sharif Md. Arman , Salekeen Rahagir , Rahman Md. Hafijur , Mahmud Sakib , Biswas Partha , Hasan Md. Nazmul , Islam Kazi Mohammed Didarul , Billah Md. Morsaline , Islam Md. Emdadul
Published: April 2023

Introduction: Garlic (Allium sativum) is widely used as a flavor-enhancing dietary ingredient and exhibits a wide spectrum of pharmacological effects. This study aimed to investigate the therapeutic effects of aqueous garlic extract to explore the bioactivity against 15-lipoxygenase (15-LOX) mediated inflammopathies. Methods: In this study, the antioxidant (DPPH free radical scavenging assay and reducing power assay), anti-inflammatory (hypotonicity-induced hemolysis assay and 15-LOX inhibition assay) and anticoagulation (serine protease inhibition assay and prothrombin time assay) effects of the aqueous garlic extract were investigated. Furthermore, in silico molecular docking and dynamic simulation analysis of reported small compounds of garlic against 15-LOX1 and 15-LOX2 were performed to figure out the most efficient phytochemical ligands and validate the anti-inflammatory potential. Results: The DPPH scavenging effect and the reducing power of the extract were found with the IC50 of 213.87 ± 1.49 μgmL-1 and EC50 of 124.78 ± 3.39 μgmL-1, respectively. In the hypotonicity-induced hemolysis and 15-LOX inhibition assay, the IC50 values were observed as 147.59 ± 2.98 μgmL-1 and 250.05 ± 8.48 μgmL-1, respectively. The extract inhibited serine protease activity with an IC50 of 301.33 ± 1.31 μgmL-1 and prevented blood coagulation for 10.05 ± 0.35 minutes in prothrombin time assay. The in silico study identified Rhamnetin as a potential 15-LOX1 and 15-LOX2 inhibitor, and it exhibited a stable interaction with the targets throughout the 100 ns dynamic simulation. Conclusion: The findings of this study provide molecular insights into garlic’s medicinal properties as well as its bioactive compounds, which can be potential therapeutic interventions for 15-LOX mediated inflammations.
Photobiomodulation Therapy for Multiple Painful Fixed Drug Eruptions: The First Case Report
Authors: Palma Luiz Felipe , Campos Luana , de Oliveira Sandro Francisco , Penido Ludmila , Morimoto Susana , de Moraes Luís Otávio Carvalho
Published: April 2023

Introduction: Fixed drug eruption (FDE), a very specific adverse drug reaction and one of the most common types of drug eruption, generally resolves spontaneously within 7-10 days upon withdrawal of the causative agent; however, extensive and severe cases may also require systemic drug therapy. The present study aimed to report a case in which a broad spectrum of severe, painful lesions of FDE was managed with photobiomodulation therapy (PBMT). Case Report:A 31-year-old Caucasian woman presented with many extremely painful mucocutaneous lesions of FDE which had arisen 8 days before, following a long period of hospitalization. The lesions were not responsive to either corticosteroids or analgesics within 5 days, and then seven daily sessions of PBMT were proposed. Pain alleviation was achieved on the 1st day of PBMT, and the lesions showed an advanced course of healing on the 3rd day. Within 7 days of PBMT, the lesions were almost completely repaired. In a 3-month follow-up period, no relapse of any FDE lesion was reported. Conclusion: PBMT may be a promising strategy for the management of painful lesions of FDE refractory to conventional medication therapy. However, further studies are needed to confirm this hypothesis.
Recovery of Quadriceps Strength and Knee Function Using Adjuvant EMG-BF After Primary ACL Reconstruction
Authors: Norozian Bahman , Arabi Samaneh , Marashipour Seyedeh Mahta , Khademi Kalantari Khosro , Akbarzadeh Baghban Alireza , Kazemi Seyyed Morteza , Jamebozorgi Ali Asghar
Published: April 2023

Introduction: Immobility and limited usage of operated limbs lead to weakness and atrophy of the muscle after anterior cruciate ligament (ACL) reconstruction. However, training programs for preventing biomechanical risk factors such as lower limb alignment and increased muscular contraction are very limited. Thus, the current study was carried out to evaluate the recovery of quadriceps muscle strength and the improvement of knee function using adjuvant electromyographic biofeedback (EMG-BF) after ACL reconstruction. Methods: This prospective randomized controlled trial was conducted among 40 patients (20=EMG-BF group, 20=Control group) with ACL reconstruction, who were referred to Akhtar Hospital from 2021 to 2022. In the EMG-BF group, EMG BFB was added to the standard rehabilitation protocol, and in the control group, the standard rehabilitation protocol with full postoperative weight-bearing, knee brace (zero degree of extension, 90 degrees of flexion), and electrical stimulation with maximal voluntary isometric knee extension was performed. Each group was intervened for 4 weeks and three sessions of 30 minutes per week. It should be noted that each patient participated in 16 outpatient physiotherapy sessions after surgery. Nicholas Hand-Held Dynamometer (HHD) was used for measuring quadriceps strength, and Knee Outcome Survey-Activities of Daily Living (KOS-ADLs) and Knee Outcome Survey Sports Activities Scale (KOS-SAS) questionnaires were used for assessing the knee function. Results: Four weeks after the treatment, the EMG-BF group showed a significant increase in quadriceps strength (P=0.0001). Quadriceps strength had a significant difference before and after 4 weeks of intervention (P=0.0001), but in the control group, no significant difference was observed (P=0.368). The EMG-BF group had a significant increase in KOS-ADLs and KOS-SAS scores after 4 weeks of intervention (P=0.0001). Conclusion: In our study, isometric strengthening of quadriceps with adjuvant EMG-BF significantly increased the strength of quadriceps and knee function during 4 weeks. EMG-BF is a low risk, low cost, and less invasive intervention and has high safety and adjustment ability. It is a valuable adjuvant method for achieving better functional recovery in a shorter time.
Keloid Treatment Using Plasma Exeresis: A Pilot Trial Study
Authors: Delavar Shohreh , Tehrani Setareh , Hassanzadeh Hournaz , Tehrani Sepideh
Published: April 2023

Introduction: Keloid scars and hypertrophic scars are more commonly seen after surgeries, suture placements, or other skin damages. Scars can be treated using a variety of methods, including topical compounds, surgery, and lasers. The aim of this study is to evaluate the effects of plasma exeresis on the treatment of keloid scars. Methods: This experimental study was conducted on patients with keloid scars, defined as a treatment-resistant subtype of scars with extension beyond the primary skin defect and cauliflower appearance, in different parts of the body. The patients were treated with 2-to-3-session plasma exeresis. Scars were examined based on the Vancouver scar scale (VSS) before and 5 months after the treatment. Results: A total number of 24 scars were enrolled in this study. The number of patients was 16. There was a decrease in the mean thickness of keloids from 2.20 to 0.54 (P=0.000). The mean pigmentation and pliability scores decreased from 1.54 and 2.16 to 0.375 and 0.541, respectively (P=0.001, 000). There was a significant reduction in the keloid scar vascularity score from 1.666 to 0.541 (P=0.000). There was a decrease from 0.708 to 0.00 (P=0.004) in the mean itchiness score. After the intervention, the mean pain score was 0.000, compared to 0.7500 before the intervention (P=0.003). There was a decrease in the total score from 8.958 to 2.000 (P=0.000). Conclusion: The plasma exeresis procedure is effective in destroying small keloid scars. Furthermore, results in less itching and pain, as well as no significant complications or recurrences.
Antimicrobial Photodynamic Therapy as a Technique for Decontamination of Acrylic Resin Devices Provided by Different Dental Laboratories
Authors: de Carvalho Bruna Marjorie Dias Frota , Garcia Bruna Albuquerque , Gomes Aghata Kelma Palacio , Alcantara Danielle Dourado , de Freitas Pontes Karina Matthes
Published: April 2023

Introduction: Dentures, occlusal splints, surgical guides and orthodontic appliances are examples of acrylic resin devices made in dental laboratories, which must be disinfected and even sterilized before insertion into the oral cavity. This study evaluated the antimicrobial effect of photodynamic therapy (PDT) applied to acrylic resin specimens received from different laboratories. Methods: Three hundred standardized specimens were ordered from six randomly selected laboratories registered in the Council of Dentistry of Ceará (n=50). The PDT consisted in the association of 22 µM erythrosine, as a photosensitizer (P), and a 520-nm LED at 38 J/cm2 (L). The specimens of each laboratory were randomly distributed into five groups: positive control, sterilized with ethylene oxide; negative control, untreated (P-L-); erythrosine control, only stained (P+L-); LED control, only irradiated (P-L+); PDT (P+L+). Then, the specimens were individually sonicated in saline solution; the suspension was diluted, plated on culture mediums (blood agar, sabouraud dextrose agar and a non-selective chromogenic agar), and incubated for 48 hours at 37°C. Colony-forming-unit (CFU) counts were done and statistical tests of Kruskal-Wallis/Dunn were carried out. Results: The specimens from all laboratories were contaminated with bacteria and yeasts. Staphylococcus aureus, Staphylococcus saprophyticus, Escherichia coli, Enterococcus spp., Klebsiella and Pseudomonas spp. were identified. The PDT significantly reduced CFU counts (P<0.0001), compared to P-L-. Conclusion: PDT was able to effectively decontaminate the acrylic resin specimens provided from dental laboratories.
Microleakage and Marginal Integrity of Surface-Coated and Laser-Pretreated Class V Composite Restorations in Primary Teeth
Authors: Azimi Niloofar , Mohammadi Najmeh , Parsaie Zahra , Fereidouni Kiarash
Published: April 2023

Introduction: Despite the advanced formulations of resin composites, microleakage is still among the commonest causes of clinical failure of these restorations. We evaluated the effect of surface coating and laser pretreatment on the microleakage of Class V resin composite restorations in primary teeth. Methods: Sixty extracted primary molar teeth having intact lingual or facial surfaces were randomly allocated into the control, G-Coat Plus surface coating, and erbium-doped yttrium aluminum garnet (Er:YAG) laser pretreatment groups. Class V cavities were provided with the coronal and gingival margins in the dentin and enamel, respectively. Restoration of the cavities was done with Z250 resin composite and they were thermocycled, followed by immersing in 2% basic Fuchsin dye for 24 hrs. Samples underwent sectioning occlusogingivally and the microleakage was assessed under a stereomicroscope (40×). Statistical analysis was done via SPSS and Kruskal-Wallis test (α=0.05). Results: The control and G-Coat plus groups were significantly different regarding the microleakage (P<0.001), and G-Coat Plus and laser pretreatment groups (P<0.001) at both gingival and occlusal margins. However, it showed no significant difference between the laser and the control group on the enamel (P=0.063) and dentin margins (P=0.757). Microleakage at the gingival margins was significantly greater compared to the occlusal margins in the control and laser groups (P<0.001), but not in the G-Coat Plus group (P=0.051). Conclusion: G-Coat plus coating significantly reduced microleakage at dentin and enamel margins of Class V composite restorations in primary teeth, in comparison with other groups of the study. Also, dentin margins showed more significant amounts of microleakage versus enamel margins in all groups, except for the G-Coat Plus group.
Designing and validation of proposing evidence-based nursing care guidelines in patients undergoing coronary angiography
Authors: Bordbar Mina , Fereidouni Zhila , Kameli Morandini Morteza , Najafi Kalyani Majid
Published: April 2023

Background and aims: Evidence-based Clinical Practice Guidelines (CPGs) are essential tools to improve the quality of nursing care. The present study aimed to design and validate proposed evidence-based nursing care guidelines in patients undergoing coronary angiography. Methods: This developmental study was performed in the angiography and post-cardiac care unit (CCU) of Vali-e-Asr hospital in Fasa in 2019. Evidence-based nursing care guidelines were designed based on the Stetler model. Ten specialized professors were interviewed in three phases to assess the content and face validity of the guidelines using an expert panel; ten specialized professors were interviewed in three phases. The application of the guidelines was also examined by a focus group discussion with ten clinical nurses. Results: In this study, eight evidence-based nursing care guidelines were designed and proposed for patients undergoing angiography. Conclusion: The development of evidence-based nursing care guidelines in patients undergoing angiography will provide more benefits, increase nurses’ access to up-to-date information, and ultimately increase the quality of nursing care.
The impact of digital technologies in nursing care and their application: A narrative review
Authors: Toghian Chaharsoughi Narges , Ahmadifaraz Mansoureh , Kahangi Leila Sadat
Published: April 2023

Background and aims: Digital technologies promise great opportunities to overcome current challenges in the care sector. Examples include the growing presence of robotic systems and society’s reliance on mobile, the internet, and social media. Despite substantial advances, challenges in the nursing use of digital technology persist. A lack of good empirical reviews of current technologies in the literature prompted us to conduct this review. Methods: This study was conducted using a narrative review method. We reviewed studies published from 2010 to 2022. Data were collected by searching different English and Persian databases, namely, Google Scholar, Elsevier, PubMed, ProQuest, and Scientific Information D atabase (SID). Search terms were "digital technology," "social media," "monitoring technologies," "eHealth services," "nursing care," "digital technology application," and "innovative technology." Results: Evidence shows that digital technology in the field of nursing care is classified into three types (types of digital technology in nursing, advantages and disadvantages of digital technology, and challenges and attitudes of nurses in the use of digital technology in nursing care). Each dimension was examined separately. This study uses digital technology in nursing care: Information and communication technology (ICT), ambient assisted living, assistive devices, monitoring/sensors, robotic technology, and virtual reality. Conclusion: Despite substantial advances, digital technology challenges persist in nursing use. Nurses must catch up with rapid changes in digital technologies and their impact on society, limiting their potential benefits to nursing practice and patient care. To respond to these challenges and prepare for the future, nursing must begin the immediate transformation into a digitally enabled profession that can respond to the complex global challenges facing health systems and society.
Managerial Competencies: A Pattern for Top Managers' Competency of Medical Sciences Universities
Authors: Ganji Mazaher , Dalvi Mohammad Reza , Shirvani Alireza
Published: April 2023

Background and aims: Managers’ competencies can influence the organization’s development and effectively promote and improve management and implementation of planned changes. This study addresses developing the pattern of specific competence of senior managers of universities of medical sciences. Methods: This research was conducted in two qualitative and quantitative phases in 2021-2022. First, it was done using a qualitative approach using conventional content analysis. The research tool was a semi-structured interview. The data from the interviews with 17 participants through the purposeful sampling method depended on the criteria. In the second phase, the variables identified in the first phase were measured through the correlation method and structural equation model using AMOS software. The tool for collecting information in this phase was a researcher-made questionnaire based on the first phase of the research. The respondents, Lawshe’s content validity ratio coefficient, and factor analysis confirmed the questionnaire’s face, content, and construct validity. Its reliability was estimated using Cronbach’s alpha coefficient at higher than 0.7. The study population of this department consists of managers in the departments of a medical sciences university (n=196). Results: The findings showed that 43 subscales were placed in 18 general categories in a paradigm model (causal factors, contextual conditions, intervening conditions, strategies, and consequences). The causal factor coefficient of the main category was 0.57, background factors on strategies were 0.59, intervening factors on strategies were 0.43, and the main category on strategies was 0.52. Finally, the factor coefficient of the strategies on the results was obtained at 0.46. Conclusion: The results of this research may contribute to knowledge about the unique competencies of top managers in the development and improvement of human resources to achieve the organization’s goals and success. These competencies can be considered in evaluating and selecting talented human resources.
The effect of a Kohlberg’s theory of moral development-based intervention on ethical reasoning in nurse interns at Shahrekord University of Medical Sciences
Authors: Soltani Matin , Etemadifar Shahram , Kheiri Soleiman
Published: April 2023

Background and aims: Nursing students represent one of the most important healthcare professionals in the health system that, along with acquiring knowledge and practical skills, should learn professional values and attitudes and nursing care ethics. The aim of this study is to investigate the effect of an intervention based on Kohlberg’s theory of moral development on the ethical reasoning of nurse interns. Methods: The present quasi-experimental study was conducted with participation of 72 nurse interns in the teaching Ayatollah Kashani and Hajar hospitals affiliated to Shahrekord University of Medical Sciences from 2019 to 2021. The nurse interns were first selected based on the inclusion criteria by census and then randomly assigned to two groups of 36 each, namely, intervention and control. In the intervention group, educational content was performed in four sessions of one and a half hours within one month. Data collection tools included a demographic characteristics checklist and Nursing Dilemma Test (NDT) which was administered at baseline and immediately and one month after the intervention to both groups. Data were analyzed by SPSS version 24 using descriptive and analytical tests such as paired t-test, independent t-test and Fisher’s exact test at a significance level of 0.05. Results: The mean (±standard deviation) score of ethical reasoning before the moral intervention were 39.16±5.74 in the control group and 39.22±1.09 in the intervention group, with no statistically significant difference by independent t test (P=0.831). The mean±standard deviation score of this variable immediately after the moral intervention was obtained 39.08±5.26 in the control group and 39.41±6.58 in the intervention group, with no statistically significant difference by independent t test (P=0.370). But the mean±standard deviation score of ethical reasoning one month after the moral intervention was 38.94±5.68 in the control group and 47.77±6.71 in the intervention group, with a statistically significant difference by independent t test (P=0.001). Conclusion: Given that most nursing students have a low level of ethical reasoning, it is necessary for nursing managers to pay more attention to the issue of professional ethics in educating students in this field. The results of the present study indicated the desirable impact of Kohlberg’s moral intervention on the ethical reasoning of nurse interns, so it is recommended to give serious attention to the use of Kohlberg’s theory of moral development -based interventions in the education of nursing students.
The effect of progressive muscle relaxation on sleep quality and postoperative pain in patients undergoing heart valve replacement surgery
Authors: Nazari Niusha , Etemadifar Shahram , Mirmohammadsadeghi Amir , Raeisi Shahraki Hadi
Published: April 2023

Background and aims: To investigate the effect of progressive muscle relaxation on sleep quality and postoperative pain in patients undergoing heart valve replacement surgery. Methods: In this quasi-experimental study, 60 patients undergoing surgery that enter were randomly divided into the muscle relaxation (n=30) or control group (n=30). Data were collected by Pittsburgh Sleep Quality Index and McGill Pain Questionnaire before and after the intervention. Patients in the control group received routine care, but patients in the muscle relaxation group performed a progressive relaxation technique twice a week for one month. Results: Most of the male participants in both groups had diplomas. There is no significant difference between the two groups of relaxation and control regarding age, gender, occupation, and education levels. The mean sleep quality score in the control group was not significantly reduced after the intervention. However, the mean sleep quality in the relaxation group before 13.90±2.23 and after the intervention was 8.03±2.01 significantly decreased (P<0.001). Also, the pain score was significantly reduced after the progressive relaxation group in the intervention group (P<0.001). Although the two groups were the same in all the dimensions of sleep quality before the intervention, significant differences were observed between groups after the intervention in all the dimensions. Conclusion: Progressive muscle relaxation has an influential role in the pain decrease and sleep quality of patients undergoing heart valve replacement surgery and can be used as a safe and cost-free method for patients.
Risk of lactic acidosis following injection of iodinated contrast medium for individuals with type 2 diabetes receiving metformin during angiography
Authors: Rahmanian Mehrdad , Moradi Samira , Raziee Fijani Maryam , Hasanpour Dehkordi Ayda , Dehghan Sara , Ghanbarzadeh Erfan , Zaremoghadam Elahe , Mardanparvar Hossein , Mohagheghi Zohreh
Published: April 2023

Lactic acidosis (LA) due to metformin prescription is a rare condition; however, this circumstance is accompanied by a very high rate of death (≥50%). Accumulation of metformin alone is hardly a cause of LA, and more than 90% of patients with metformin-associated LA had a hypoxic condition that could prompt hazards of LA. LA related to this drug occurs after iodinated contrast material (ICM) exposure when other contraindications to metformin use, particularly renal insufficiency neglected and leading to high plasma metformin accumulation. One of the most common questions for radiologists is when and at what level of kidney function this agent should be discontinued in cases receiving ICM and restarted again. In this study, we assess the requirement of metformin discontinuation in diabetic patients with chronic kidney disease (CKD) who are candidates for ICM. Therefore, we evaluate the step and withholding time of metformin discontinuation in CKD patients programmed for angiography with an intravenous contrast agent. Results demonstrated that for patients with uncertain renal function and individuals with normal estimated glomerular filtration rate and other diseases, the assessment to discontinue metformin (Before or at the time of the procedure) and when to reinitiate this drug should be made the decision, based on the individual’s circumstances.
Comparison of hemodynamic indices of dialysis patients in continuous renal replacement therapy and intermittent renal replacement therapy methods with ultrasonic cardiac output monitor in intensive care unit
Authors: Najafi Atabak , Vakili Ardabili Ayda , Aghsaeifard Ziba , Sharifnia Hamidreza
Published: April 2023

Introduction: Acute kidney injury (AKI) is a common complication in the intensive care unit (ICU) and is independently associated with end-stage renal disease and higher mortality in the ICU. There are different methods to supporting kidney function in critically ill patients. The renal replacement therapy (RRT) can be conducted continuously, intermittently, or in combination. Objectives: The purpose of our study is to investigate the hemodynamic indices of dialysis patients in the ICU by two methods high flow continuous renal replacement therapy (CRRT) and intermittently renal replacement therapy (IRRT) of ultrasonic cardiac output monitor (USCOM). Patients and Methods: In this study conducted at Sina hospital, patients requiring dialysis hospitalized to the ICU were studied. Around 48 patients benefited from rapid CRRT or IRRT in the opinion of a specialist. Basic patient information was recorded. To check hemodynamic parameters during dialysis, USCOM was carried out to check corrected flow time value (FTc) parameters, systemic vascular resistance (SVR) and cardiac output. Results were compared between the IRRT and CRRT groups. Results: This study was conducted on 48 patients who were candidates for dialysis. Patients were divided into high flow CRRT and IRRT groups based on clinical indications. In CRRT group, 19 patients (79.2%) and in the IRRT group, 20 patients (83.3%) were male (P=0.712). Their mean age was 68.70 ± 8.25 years in the CRRT group and 68.58 ± 7.19 years in the IRRT group. All patients had cardiac output monitored using USCOM or ultrasound. The mean Sequential Organ Failure Assessment (SOFA) score in the CRRT group was 7 and in the IRRT group was 6, with no significant difference among them. FTc value variable or modified flow time in the carotid artery, cardiac output, cardiac index, SVR variable and mean arterial pressure in in the two groups at four evaluated times (before dialysis, 15 minutes later, one hour later and end of dialysis) from the study the difference were not statistically significant. Conclusion: Although previos studies have recommended CRRT, our study showed significant difference may not be existed between IRRT and CRRT.
COVID-19 outcomes in kidney transplant recipients receiving a combination of sofosbuvir-daclatasvir treatment; a single-center study
Authors: Yaghoubi Fatemeh , Tavakoli Farnaz , Dalil Davood , Akhavan Marjan , Abbasloo Samira
Published: April 2023

Introduction: In the coronavirus disease 2019 (COVID-19) era, kidney transplantation recipients (KTRs) are at high risk due to using immunosuppressive drugs. Considering the lack of definitive cure for COVID-19, repurposing existing pharmaceuticals is a way to find an immediate medication. Objectives: This study aimed to evaluate the COVID-19 outcomes in KTRs, receiving combination of sofosbuvir and daclatasvir (SOF-DAC) treatment. Patients and Methods: This research was an observational study of 12 adult kidney transplant recipients with COVID-19, admitted to Shariati hospital, Tehran, Iran (October to December 2020). All the patients received a once-daily combination pill of SOF-DAC at a dose of 400/60 mg for 10 days. Results: Around October to December 2020, 12 adult KTR patients were recruited; four patients (33.3%) died and eight patients survived (66.7%). Acute kidney injury (AKI) secondary to COVID-19 was seen in 11 patients of the study population (91.7%), including four dead cases. Two of the three patients who underwent dialysis due to kidney complications, died. The laboratory results showed that the mean level of each parameter white blood cells (WBC), international normalized ratio (INR), C-reactive protein (CRP), ferritin, D-dimer on the last day of hospital stay was significantly different between two groups of survived and dead patients at a 95% confidence level (P<0.05). Conclusion: Sofosbuvir combined with DAC for treatment of KTRs with COVID-19 infection reduced the mortality rate. Further, this medication was safe. Patients tolerated it well, and no serious adverse effects were observed. Larger studies are needed to validate these results.
The effect of metformin administration on cancer-specific survival, overall survival, progression-free survival, and disease progression in renal cell carcinoma patients; a systematic review and meta-analysis
Authors: Nourmohammadi Hassan , Jamshidbeigi Tayebe , Abdan Zahra , Sarokhani Diana , Fakhri Moloud , Alaienezhad Shakiba
Published: April 2023

Introduction: The increase in the incidence of renal cell carcinoma (RCC) has been reported worldwide. The anti-cancer impacts of metformin on the various types of cancer have been observed in clinical studies. Therefore, this study aims to survey the effect of metformin use on RCC patients using systematic review and meta-analysis methods. Materials and Methods: In this research, Cochrane, Web of Science, PubMed, Scopus databases, and Google Scholar web browser were searched using standard keywords. Data were analyzed with STATA 14 software. The significance level of tests P<0.05 was considered. Results: The improvement in the progression-free survival (PFS) (HR: 0.72 [95% CI: 0.54, 0.94], P=0.169, I2=37.8%) and cancer-specific survival (CSS) (HR: 0.36 [95% CI: 0.18, 0.75], P=0.339, I2=7.5%) was observed in eight studies with 10404 patients affected by RCC. However, no significant statistical effect was observed on the improvement in the disease progression (OR: 1.10 [95% CI: 0.85, 1.42], P=0.326, I2=0%) and cancer overall survival (OS) (HR: 0.72 (95% CI: 0.51, 1.01), P=0.153, I2=43.1%). Conclusion: This study showed metformin administration improved CSS and PFS in RCC patients. More studies are warranted on the effect of metformin on the improvement in disease progression and OS of cancer. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO website (ID= CRD42022369108; https://www.crd.york. ac.uk/prospero/display_record.php?ID=CRD42022369108).
Kidney injury molecule-1; is it a predictive marker for renal diseases?
Authors: Anandkumar Deepashree Goravigere , Dheerendra Prashant Chippalkatti , Vellakampadi Deepesh , Ramanathan Gnanasambandan
Published: April 2023

Kidney injury is the main cause of mortality and morbidity globally. The kidney injury molecule (KIM-1) is a type 1 transmembrane protein, which is been upregulated during renal injury at high levels in urine, serum, plasma, and tissues and plays a crucial role in the pathogenesis of renal diseases. Kidney injury molecule has been used as a marker for the diagnosis of renal disease at an early stage as well as to predict the progression of disease with a clinical outcome. This review article aims to discuss and summarize the available literature data regarding KIM-1 being a potential marker for diagnostic, therapeutic, and prognosis of clinical outcomes and management in kidney diseases. We also discuss the relationship between KIM-1 and kidney injury in a few common renal diseases such as acute pyelonephritis, acute tubular nephrosis (ATN), diabetic kidney disease (DKD), acute kidney injury (AKI), chronic kidney disease (CKD), and other pathologies.
A Comprehensive Assessment of Rehabilitation Potential in Patients with Neuropathies
Authors: Чапко И.Я. , Филиппович А.Н. , Овсянник Ю.А. , Перкова В.Е.
Published: April 2023

Введение. Реабилитационный потенциал представляет совокупность потенциальных возможностей пациента, основанную на комплексной экспертно-реабилитационной диагностике, определяющей прогноз эффективности медицинской реабилитации, максимальную возможность восстановления или компенсации нарушенных функций органов и систем организма. Цель. Разработать метод оценки реабилитационного потенциала пациентов с травматическими и компрессионно-ишемическими невропатиями. Материалы и методы. В исследование включены 62 пациента в возрасте от 18 до 63 лет с наличием периферического вялого пареза различной степени выраженности (62 чел., 100%), алгического синдрома (33 чел., 53,2%), нейротрофическими (23 чел., 37,1%) и вегетососудистыми нарушениями (14 чел., 22,6%). Результаты. Определение реабилитационного потенциала целесообразно выполнять на основе анализа трех групп факторов: медицинских, психологических, социальных, а также с использованием оценки функций, структур, активности и участия. С учетом положений Международной классификации функционирования, ограничений жизнедеятельности и здоровья были выделены критерии, характеризующие высокий, средний и низкий потенциал. Заключение. Оценка реабилитационного потенциала учитывалась при формировании реабилитационного диагноза и составлении индивидуальной программы медицинской реабилитации, абилитации пациента, позволяла определить задачи реабилитации для мультидисциплинарной реабилитационной бригады.

Introduction. Rehabilitation potential represents the overall potential of a patient, based on a comprehensive expert and rehabilitation diagnosis, which determines the prognosis for medical rehabilitation efficiency, the maximum possibility of restoring or compensating for impaired functions of organs and body systems. Purpose. To elaborate a method for rehabilitation potential assessment in patients with traumatic and compression ischemic neuropathies. Materials and methods. The study included 62 patients aged 18 to 63 years with peripheral flaccid paresis of varying severity (62 subjects, 100%), algic syndrome (33 subjects, 53.2%), neurotrophic (23 subjects, 37.1%) and vegetative-vascular disorders (14 subjects, 22.6%). Results. It is expedient to determine the rehabilitation potential based on the analysis of three groups of factors: medical, psychological, social, as well as using an assessment of functions, structures, activity and participation. Taking into account the provisions of the International Classification of Functioning, Disabilities and Health, criteria were identified characterizing high, medium and low potential. Conclusion. The assessment of rehabilitation potential was taken into account when formulating a rehabilitation diagnosis and drawing up an individual program of medical rehabilitation and habilitation for each patient, allowing to determine rehabilitation tasks for a multidisciplinary rehabilitation team.
ANALISIS FAKTOR-FAKTOR YANG MEMENGARUHI PROFITABILITAS PADA PERUSAHAAN MAKANAN DAN MINUMAN YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI) PERIODE 2015-2020
Authors: Ng Martha , Chandra Stefani , Septaundari Septaundari
Published: April 2023

Tujuan dari penelitian ini adalah untuk mengetahui informasi tentang pengaruh dari solvabilitas dan aktivitas terhadap profitabilitas pada perusahaan makanan dan minuman di Bursa Efek Indonesia tahun 2015-2020. Variabel yang digunakan adalah ROA sebagai variabel dependen dan variabel independen adalah TDTA, LTDTA, STDTA, TATO dan ITO. Penelitian ini menggunakan teknik purposive sampling dan mendapatkan 17 sampel perusahaan Makanan dan Minuman. Metode analisis yang digunakan adalah regresi linier. Hasil penelitian ini menunjukkan bahwa TDTA mengalami multikolinearitas sehingga variabel ini tidak dapat diteliti lebih lanjut. STDTA dan ITO berpengaruh positif dan tidak signifikan terhadap ROA, sebaliknya LTDTA berdampak negatif signifikan terhadap ROA dan TATO tidak mempunyai dampak yang signifikan terhadap ROA.
PENGARUH PENERAPAN PSBB & PPKM TERHADAP HARGA SAHAM PERUSAHAAN-PERUSAHAAN SEKTOR BARANG KONSUMEN PRIMER YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Chandra Jennifer , Marlin Stephen
Published: April 2023

Dalam penelitian ini digunakan pendekatan event study untuk mempelajari kinerja dan reaksi pasar pada perusahaan-perusahaan sektor barang konsumen primer terhadap pandemi Covid-19. Penelitian ini bertujuan untuk menguji pengaruh keempat pengumuman terkait pembatasan sosial Covid-19 terhadap abnormal return dan trading volume activity pada 74 perusahaan sampel di Bursa Efek Indonesia. Menggunakan metode event study dan data sekunder berupa harga saham harian, jumlah transaksi harian, dan indeks gabungan harian selama tiga hari sebelum dan tiga hari setelah tanggal peristiwa, yang diuji dengan Paired Sample t-Test dan Wilcoxon Signed Rank Test. Hasil penelitian menunjukkan adanya abnormal return secara signifikan pada saat PSBB pertama kali diumumkan. Sedangkan abnormal return saat PSBB transisi, PPKM, dan PPKM darurat tidak signifikan. Perbedaan trading volume activity sebelum dan sesudah keempat pengumuman PSBB dan PPKM juga tidak signifikan.
Aplicabilidade das boas práticas de fabricação em restaurantes tipo self service da cidade de Sobral-CE
Authors: Magalhães de Freitas Débora Mirley , Barros Cavalcante Carlos Eliardo , Pinto Farias Mirla Dayanny , Arrais Jales Katiane
Published: April 2023

O objetivo principal desta obra é servir como fonte de estudo e consulta, tanto para os estudantes no âmbito das áreas de alimentos, como para profissionais da saúde, com enfoque mais didático, científico e atual. Poderá ser utilizado em diversos estabelecimentos que envolvam manipulação de alimentos: restaurantes, lanchonetes, hospitais, hotéis, escolas, creches, aeroportos até mesmo ambientes domiciliar. Os profissionais convidados para escreverem os doze capítulos foram escolhidos por seus relevantes trabalhos em suas respectivas especialidades na área de Segurança Alimentar e Nutricional, encontrando-se aptos a abordar com profundidade os temas discorridos. Dessa forma, os temas abordados serão de grande valia para os leitores que buscam garantir a qualidade dos seus serviços visando a saúde, através de alguns aspectos como ingestão, absorção, excreção adequados de todos os alimentos a serem consumidos.
Elaboração de um roteiro de história em quadrinhos para trabalhar a segurança de alimentos com crianças do Ensino Fundamental I
Authors: Freire Fontele Maria Luiza , Gomes de Sousa Ana Cléa , Lima de Araujo Paolo Germanno , da Silveira Queiroz Herlene Greyce
Published: April 2023

O objetivo principal desta obra é servir como fonte de estudo e consulta, tanto para os estudantes no âmbito das áreas de alimentos, como para profissionais da saúde, com enfoque mais didático, científico e atual. Poderá ser utilizado em diversos estabelecimentos que envolvam manipulação de alimentos: restaurantes, lanchonetes, hospitais, hotéis, escolas, creches, aeroportos até mesmo ambientes domiciliar. Os profissionais convidados para escreverem os doze capítulos foram escolhidos por seus relevantes trabalhos em suas respectivas especialidades na área de Segurança Alimentar e Nutricional, encontrando-se aptos a abordar com profundidade os temas discorridos. Dessa forma, os temas abordados serão de grande valia para os leitores que buscam garantir a qualidade dos seus serviços visando a saúde, através de alguns aspectos como ingestão, absorção, excreção adequados de todos os alimentos a serem consumidos.
Plantas medicinais alimentícias que contribuem para o aumento da imunidade: uma revisão sistemática
Authors: Rodrigues Maciel Danielle , Rodrigues Maciel Maria Gabrielle , Silva Lima Joilson , Carvalho Moreira Francisco José , Alves Teixeira de Sá Daniele Maria
Published: April 2023

O objetivo principal desta obra é servir como fonte de estudo e consulta, tanto para os estudantes no âmbito das áreas de alimentos, como para profissionais da saúde, com enfoque mais didático, científico e atual. Poderá ser utilizado em diversos estabelecimentos que envolvam manipulação de alimentos: restaurantes, lanchonetes, hospitais, hotéis, escolas, creches, aeroportos até mesmo ambientes domiciliar. Os profissionais convidados para escreverem os doze capítulos foram escolhidos por seus relevantes trabalhos em suas respectivas especialidades na área de Segurança Alimentar e Nutricional, encontrando-se aptos a abordar com profundidade os temas discorridos. Dessa forma, os temas abordados serão de grande valia para os leitores que buscam garantir a qualidade dos seus serviços visando a saúde, através de alguns aspectos como ingestão, absorção, excreção adequados de todos os alimentos a serem consumidos.
Relato dos empresários de serviços de alimentação do município de Ubajara-CE sobre a aplicação de boas práticas de fabricação para uma gestão de qualidade no período de pandemia do Covid-19
Authors: Araújo Maria Judite , Portela Pereira Júlio Otávio , Alves Teixeira de Sá Daniele Maria , Capistrano Camurça Portela Masu
Published: April 2023

O objetivo principal desta obra é servir como fonte de estudo e consulta, tanto para os estudantes no âmbito das áreas de alimentos, como para profissionais da saúde, com enfoque mais didático, científico e atual. Poderá ser utilizado em diversos estabelecimentos que envolvam manipulação de alimentos: restaurantes, lanchonetes, hospitais, hotéis, escolas, creches, aeroportos até mesmo ambientes domiciliar. Os profissionais convidados para escreverem os doze capítulos foram escolhidos por seus relevantes trabalhos em suas respectivas especialidades na área de Segurança Alimentar e Nutricional, encontrando-se aptos a abordar com profundidade os temas discorridos. Dessa forma, os temas abordados serão de grande valia para os leitores que buscam garantir a qualidade dos seus serviços visando a saúde, através de alguns aspectos como ingestão, absorção, excreção adequados de todos os alimentos a serem consumidos.
IMAGENS NA ESCOLA: PORQUE E COMO PODEM MELHORAR A APRENDIZAGEM
Authors: Pompeia Sabine , Marques Luiz
Published: April 2023

Este e-book gratuito para professores discute por que e de que formas imagens podem auxiliar na compreensão e retenção de informações, bem como na ampliação de conhecimentos gerais. São apresentados exemplos de como usar esse tipo de recurso para esses fins em todas as disciplinas e com alunos de qualquer idade, mas com foco em adolescentes. São abordados: 1) as vantagens para a aprendizagem de empregar imagens durante a exposição a novos conteúdos; 2) as vantagens de usar imagens para estudar e/ou aprofundar conhecimentos já apresentados; 3) a importância de promover a literacia visual; 4) a possibilidade de usar a criatividade a partir de imagens e, assim, melhorar o aprendizado; 5) critérios a serem atendidos para selecionar imagens adequadas; 6) exemplos de perguntas e atividades que podem maximizar o potencial de imagens em promover o aprendizado; 7) como e onde buscar imagens online; 8) onde procurar informações sobre as principais técnicas artísticas (por exemplo, diferentes tipos de pintura, escultura etc.); e 9) exemplos de imagens de obras de arte que retratam adolescentes ao longo da história com variadas técnicas artísticas.O objetivo desta obra é, sobretudo, instrumentalizar os professores a usar imagens de qualquer natureza como recursos para enriquecer suas práticas pedagógicas.
Factors Associated with Nurses’ Attitude towards Patient Safety Culture in an International Accredited Tertiary Care Hospital, Islamabad
Authors: Kausar Raisa , Janjua Kholood , Siddique Mainmoona , Victor Gideon
Published: April 2023

Background: Patient safety has emerged as a prime agenda over the past few decades to deliver safe care in increasingly complex service delivery. This study was set out to measure the factors associated with the safety attitudes of nurses.

Methodology: This descriptive cross-sectional research was conducted from May 2017 to June 2018 in Shifa International Hospital, Islamabad. Nurses were invited to participate in the study. The safety attitude questionnaire was used for data collection. Data were analyzed using SPSS v23.0.

Results: The response rate was 86%. Job satisfaction was high at 78.37±23.63 while stress recognition was low at 53.18±27.68. Nurses liked their job being a nurse 79.92±28.01 and workplace conditions 80.33±26.44. Whereas, hostile situations 48.92±34.95, the negative effect of fatigue 48.50±35.32, being held back to report patient problems 47.58±34.76 and discuss errors 45.42±34.79 were also highlighted. Safety attitudes were statistically significant high among intensive care nurses (P-Value < 0.05). Safety scores of nurses with longer job duration were high than those with lesser job duration. Teamwork was favorably correlated with safety climate, job satisfaction, perception of management, and working conditions (R > .466, P-Value < .01).

Conclusion: There was a positive attitude of nurses toward patients’ safety with some areas of improvement.

Keywords: Attitude, Nurse, Patient safety, Practice
Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst
Authors: Rasul Faiz , Saif Rabiya , Jehangir Hafiz Majid , Rizvi Zainab , Wahid Sultan , Nadeem Khurram
Published: April 2023

Background: Biological behaviour of Odontogenic Keratocyst (OKC) is aggressiveness than others Odontogenic Cysts (OCs) like Dentigerous Cyst (DCs) and Periapical Cyst/Residual Cysts (RCs). The aim of the study was to determine clinicopathological features and expression of Ki-67 in Odontogenic Cysts of the oral cavity.

Methodology: This cross-sectional study was conducted at de’Montmorency College of Dentistry (DCD from Feb, 2020 to Feb, 2022 after approval from Institutional Review Board (IRB) of DCD. A total 78 cases of OCs were collected from hospitals which are affiliated with the DCD. Routine lab process for Hematoxylin & Eosin and Immunohistochemistry was performed. Data entry and statistical analysis was carried out in SPSS 21. A Chi- square test was applied to observe the association between cyst and Ki-67. P value < 0.05 was taken as statistically significant.    

Results: Among total 78 cases the mean age was 25.08 ±14.5 years with an age range of 6-70 years. Most OCs (64.1%) were reported in males than females (35.89%). Most OCs were reported in mandible (56.4%. Ki-67 expression in OKC was high 7.7%, low in 76.9% and negative in 15.4%). Most of the DCs and RCs expressed low expression of Ki-67 (84.6% and 76.9% respectively).  

Conclusion: Most of the odontogenic cysts expressed low expression of Ki-67 while few cases of OKC and DC expressed high expression.

Keywords: Dentigerous Cyst, Odontogenic Keratocyst, Immunohistochemistry, Ki-67, Odontogenic Cysts, Periapical Cyst, Radicular Cyst.