bluuebunny/crossref_metadata_2025 huggingface dataset:
Publisher Correction: Seasonal synchronization of sleep timing in industrial and pre-industrial societies
Authors: Martín-Olalla José María
Published: October 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper
The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models
Authors: Garcia-Moure Marc , Martinez-Velez Naiara , Gonzalez-Huarriz Marisol , Marrodán Lucía , Cascallo Manel , Alemany Ramón , Patiño-García Ana , Alonso Marta M.
Published: October 2019

Last advances in the treatment of pediatric tumors has led to an increase of survival rates of children affected by primitive neuroectodermal tumors, however, still a significant amount of the patients do not overcome the disease. In addition, the survivors might suffer from severe side effects caused by the current standard treatments. Oncolytic virotherapy has emerged in the last years as a promising alternative for the treatment of solid tumors. In this work, we study the anti-tumor effect mediated by the oncolytic adenovirus VCN-01 in CNS-PNET models. VCN-01 is able to infect and replicate in PNET cell cultures, leading to a cytotoxicity and immunogenic cell death. In vivo, VCN-01 increased significantly the median survival of mice and led to long-term survivors in two orthotopic models of PNETs. In summary, these results underscore the therapeutic effect of VCN-01 for rare pediatric cancers such as PNETs, and warrants further exploration on the use of this virus to treat them.
Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish
Authors: Mano Hiroaki , Asaoka Yoichi , Kojima Daisuke , Fukada Yoshitaka
Published: October 2019

The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) is a key regulator conferring individuality on the pineal gland between the two serially homologous photoreceptive organs in zebrafish. Bsx knock-down impaired the pineal development with reduced expression of exorh, the pineal-specific gene responsible for the photoreception, whereas it induced ectopic expression of rho, a retina-specific gene, in the pineal gland. Bsx remarkably transactivated the exorh promoter in combination with Otx5, but not with Crx, through its binding to distinct subtypes of PIRE, a DNA cis-element driving Crx/Otx-dependent pineal-specific gene expression. These results demonstrate that the identity of pineal photoreceptive neurons is determined by the combinatorial code of Bsx and Otx5, the former confers the pineal specificity at the tissue level and the latter determines the photoreceptor specificity at the cellular level.
Ribonuclease H-cleavable and recombinase-quenching fluorescent probes for the real-time detection of strand invasion based amplification
Authors: Elf Sonja , Eboigbodin Kevin E.
Published: October 2019

SIBA is an established nucleic acid amplification method that is used as an alternative to polymerase chain reaction (PCR).
A systematic data screening strategy for comprehensive characterization of chemical components in Suan-Zao-Ren decoction and their metabolic profiles in the plasma and brain of rats using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry
Authors: Du Yiyang , Wu Bo , Xiao Feng , Yan Tingxu , Jia Ying , Bi Kaishun , He Bosai
Published: October 2019

Suan-Zao-Ren decoction is a classic traditional Chinese medicinal prescription, which has been used in the clinical treatment of insomnia and anxiety for thousands of years.
Radial multi-stationary phase thin-layer chromatography for the field-ready fingerprinting of herbal materials
Authors: Sibug-Torres Sarah May , Padolina Isagani D. , Enriquez Erwin P.
Published: October 2019

A novel TLC plate design that features multiple screen printed phenyl- and octyl-modified silica gel stationary phases configured as radial sectors was developed for the in-field screening of herbal materials.
An Fe3O4/PEDOT:PSS nanocomposite as an advanced electroconductive material for the biosensing of the prostate-specific antigen in unprocessed human plasma samples
Authors: Shaban Mina , Hasanzadeh Mohammad , Solhi Elham
Published: October 2019

A novel sandwich-type biosensor based on a signal amplification strategy of various nanocomposites was developed to monitor the prostate-specific antigen (PSA) in real samples.
Comment on “Exploiting electronic strategies to stabilize a planar tetracoordinate carbon in cyclic aromatic hydrocarbons” by O. Yañez et al., Chem. Commun., 2017, 53, 12112
Authors: Thimmakondu Venkatesan S.
Published: October 2019

Unequivocally, the global minimum geometry for C7H2 is the linear triplet ground electronic state of heptatriynylidene (1).
Stepwise dual stimuli triggered dual drug release by a single naphthalene based two-photon chromophore to reverse MDR for alkylating agents with dual surveillance in uncaging steps
Authors: Roy Biswajit , Kundu Moumita , Singh Amit Kumar , Singha Tara , Bhattacharya Sayantan , Datta Prasanta Kumar , Mandal Mahitosh , Singh N. D. Pradeep
Published: October 2019

A single chromophore based dinitrophenylsulphonyl–naphthalene–chlorambucil conjugate drug delivery system is presented for the dual stimuli controlled release of SO2and chlorambucil.
Direct monitoring of equilibrium protein folding–unfolding by atomic force microscopy: pushing the limit
Authors: Xiao Adam , Li Hongbin
Published: October 2019

We report the direct observation of equilibrium folding–unfolding dynamics of a mechanically labile, three helix bundle protein GA using a commercial atomic force microscope (AFM).
Molecular spinning top: visualizing the dynamics of M3N@C80 with variable temperature single crystal X-ray diffraction
Authors: Liu Fupin , Spree Lukas
Published: October 2019

The temperature dependent rotation of Ho2LuN and Lu3N within a C80 fullerene cage has been visualized.
Reply to the ‘Comment on “Exploiting electronic strategies to stabilize a planar tetracoordinate carbon in cyclic aromatic hydrocarbons”’ by V. S. Thimmakondu, Chem. Commun., 2019, DOI: 10.1039/c9cc04639a
Authors: Yañez Osvaldo , Vásquez-Espinal Alejandro , Pino-Rios Ricardo , Ferraro Franklin , Pan Sudip , Osorio Edison , Merino Gabriel , Tiznado William
Published: October 2019

The authors respond to the Comment by Thimmakondu, showing that the effectiveness of their approach to stabilize a planar tetracoordinate (ptC) carbon in cyclic aromatic hydrocarbons is unquestionable, since their results are reproducible and reliable.
Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation
Authors: Zhao Jingnan , Yang Fan , Yu Zongyi , Tang Xiaofei , Wu Yufeng , Ma Cunfei , Meng Qingwei
Published: October 2019

A visible light-mediated α-functionalization of 1,3-dicarbonyl compounds with switchable selectivity induced by disulfide is disclosed.
Transition metal-catalyzed sp3 C–H activation and intramolecular C–N coupling to construct nitrogen heterocyclic scaffolds
Authors: Zhang Ming , Wang Qiuhong , Peng Yiyuan , Chen Zhiyuan , Wan Changfeng , Chen Junmin , Zhao Yongli , Zhang Rongli , Zhang Ai Qin
Published: October 2019

Nitrogen heterocycles are of great medicinal importance, and the construction of nitrogen heterocyclic scaffolds has been one of the focuses in synthetic organic chemistry.
Rod-like transition first or chain aggregation first? ordered aggregation of rod-like poly(p-phenyleneethynylene) chains in solution
Authors: Hattori Yusuke , Nishimura Nozomi , Tsutsui Yusuke , Ghosh Samrat , Sakurai Tsuneaki , Sugiyasu Kazunori , Takeuchi Masayuki , Seki Shu
Published: October 2019

Extremely small energetic disorder of electronically-conjugated poly(p-phenyleneethynylene) chains.
Ultralow cross-plane lattice thermal conductivity caused by Bi–O/Bi–O interfaces in natural superlattice-like single crystals
Authors: Di Chen , Pan Jia-Hui , Dong Song-Tao , Lv Yang-Yang , Yan Xue-Jun , Zhou Jian , Yao Shu-Hua , Lu Hong , Gusev Vitalyi E. , Chen Yan-Feng , Lu Ming-Hui
Published: October 2019

Revealing the impact of Bi–O/Bi–O interfaces with van der Waals interactions on the formation of ultralow cross-plane lattice thermal conductivity.
Rationalizing the diversity of amide–amide H-bonding in peptides using the natural bond orbital method
Authors: Brenner Valérie , Gloaguen Eric , Mons Michel
Published: October 2019

Natural bond orbital (NBO) analysis of electron delocalization in a series of capped isolated peptides is used to diagnose amide–amide H-bonding and backbone-induced hyperconjugative interactions, and to rationalize their spectral effects.
Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses
Authors: Chen Qian , Chen Muchao , Liu Zhuang
Published: October 2019

Cancer immunotherapy by educating or stimulating patients’ own immune systems to attack cancer cells has demonstrated promising therapeutic responses in the clinic.
Tb(HSO4)(SO4) – a green emitting hydrogensulfate sulfate with second harmonic generation response
Authors: Netzsch Philip , Bariss Harijs , Bayarjargal Lkhamsuren , Höppe Henning A.
Published: October 2019

Green emitting Tb(HSO4)(SO4) crystallises in the non-centrosymmetric space group P21 and represents a new sulfate non-linear optical material with a SHG response comparable to KH2PO4 (KDP).
Development of predictive models for silicone rubber–water partition coefficients of hydrophobic organic contaminants
Authors: Sun Huichao , Yang Xianhai , Li Xuehua , Jin Xiaochen
Published: October 2019

The developed TLSER and QSAR models can be used to predict silicone rubber (passive sampler material)–water partition coefficient (Ksrw) of hydrophobic organic compounds (HOCs).
Cereal bars functionalized through Bifidobacterium animalis subsp. lactis BB-12 and inulin incorporated in edible coatings of whey protein isolate or alginate
Authors: Pereira Joana Odila , Soares José , Monteiro Maria J. P. , Amaro Ana , Gomes Ana , Pintado Manuela
Published: October 2019

Currently, cereal bars are gaining interest globally because of their nutritionally balanced and convenient nature.
Effects of diosgenin and its derivatives on atherosclerosis
Authors: Wu Fang-Chun , Jiang Jian-Guo
Published: October 2019

The effects of diosgenin are discussed with respect to endothelial dysfunction, lipid profile, macrophage foam cell formation, VSMC viability, thrombosis and inflammation during the formation of atherosclerosis.
Geography and ethnicity related variation in the Chinese human milk serum proteome
Authors: Zhang Lina , Ma Ying , Yang Zhenyu , Jiang Shan , Liu Jun , Hettinga Kasper A. , Lai Jianqiang , Zhou Peng
Published: October 2019

Human milk provides a range of nutrients and bioactive components, which can support the growth and development of infants.
Perpetual sedimentation for the continuous delivery of particulate suspensions
Authors: Lane Simon I. R. , Butement Jonathan , Harrington Jack , Underwood Tim , Shrimpton John , West Jonathan
Published: October 2019

Particles in a rotating fluid experience gravity-directed orbits to remain in suspension.
Recent insights into natural product inhibitors of matrix metalloproteinases
Authors: Kumar Geetha B. , Nair Bipin G. , Perry J. Jefferson P. , Martin David B. C.
Published: October 2019

Members of the matrix metalloproteinase (MMP) family have biological functions that are central to human health and disease, and MMP inhibitors have been investigated for the treatment of cardiovascular disease, cancer and neurodegenerative disorders.
Impact of the Ga flux incidence angle on the growth kinetics of self-assisted GaAs nanowires on Si(111)
Authors: Vettori Marco , Danescu Alexandre , Guan Xin , Regreny Philippe , Penuelas José , Gendry Michel
Published: October 2019

In this work we show that the incidence angle of group-III element fluxes plays a significant role in the diffusion-controlled growth of self-assisted III–V nanowires by molecular beam epitaxy.
Adsorption of charged anisotropic nanoparticles at oil–water interfaces
Authors: Bergfreund Jotam , Sun Qiyao , Fischer Peter , Bertsch Pascal
Published: October 2019

Oil properties significantly affect the adsorption of charged anisotropic nanoparticles at oil–water interfaces.
Fluorinated boron subphthalocyanines: Lewis acid based templating chemistry facilitates random halide exchange, and fluoride versus chloride affects the basic photophysical properties and the solid-state arrangement
Authors: Bukuroshi Esmeralda , Vestfrid Jenya , Gross Zeev , Bender Timothy P.
Published: October 2019

A sub-group of the phthalocyanine family, the boron subphthalocyanines (BsubPcs), have robust chemistry and can be readily modified at the axial and peripheral positions to tune their physical properties.
Ethinyl estradiol cocrystals assembled by chain structures: improvement in stability and solubility
Authors: Du Rongkai , Xu Juan , Zhang Lei , Ning Lifeng , Li Shan
Published: October 2019

EE could form cocrystals with N-containing CCFs to attune the hygroscopicity and dissolution performance.
Green synthesis of Ag@Au bimetallic regenerated cellulose nanofibers for catalytic applications
Authors: Gopiraman Mayakrishnan , Saravanamoorthy Somasundaram , Baskar Ramaganthan , Ilangovan Andivelu , Ill-Min Chung
Published: October 2019

Highly active and reusable bimetallic Ag@Au/CNC nanocomposite was successfully obtainedviaa simple green synthesis for the reduction of nitrophenol and aza-Michael reaction.
Novel polymorphic phase of two-dimensional VSe2: the 1T′ structure and its lattice dynamics
Authors: Duvjir Ganbat , Choi Byoung Ki , Ly Trinh Thi , Lam Nguyen Huu , Chun Seung-Hyun , Jang Kyuha , Soon Aloysius , Chang Young Jun , Kim Jungdae
Published: October 2019

Bilayer VSe2 shows polymorphic 1T′ structure which can transit to the dynamic state of lattice vibrations, triggered by tunneling current.
Highly efficient broadband photodetectors based on lithography-free Au/Bi2O2Se/Au heterostructures
Authors: Liu Xiaolong , Li Ruiping , Hong Chengyun , Huang Gangfeng , Pan Danfeng , Ni Zhenhua , Huang Yongqing , Ren Xiaomin , Cheng Yingchun , Huang Wei
Published: October 2019

Highly efficient metal/semiconductor/metal structured photodetectors were constructed based on Bi2O2Se thin films with lithography-free electrode fabrication.
Polymer stiffness governs template mediated self-assembly of liposome-like nanoparticles: simulation, theory and experiment
Authors: Shen Zhiqiang , Loe David T. , Fisher Alessandro , Kröger Martin , Rouge Jessica L. , Li Ying
Published: October 2019

This study suggests that the self-assembly of a template-mediated liposome (TML) can be utilized as a general method to produce liposomes with controlled sizes.
Dipole modelling for a robust description of subdiffractional polariton waves
Authors: Feres Flávio H. , Barcelos Ingrid D. , Mayer Rafael A. , dos Santos Thiago M. , Freitas Raul O. , Raschke Markus B. , Bahamon Dario A. , Maia Francisco C. B.
Published: October 2019

A full electromagnetic dipole model for extraction of photonic properties and simulation of polariton waves is used.
Synthesis of Bi4Ti3O12 decussated nanoplates with enhanced piezocatalytic activity
Authors: Wu Jiang , Qin Ni , Lin Enzhu , Yuan Baowei , Kang Zihan , Bao Dinghua
Published: October 2019

Bi4Ti3O12 decussated nanoplates were successfully synthesized by a novel template hydrothermal method, which show an excellent piezocatalytic performance.
Tunable plasmonic HfN nanoparticles and arrays
Authors: Askes Sven H. C. , Schilder Nick J. , Zoethout Erwin , Polman Albert , Garnett Erik C.
Published: October 2019

Refractory plasmonic materials offer the benefits of thermal and chemical stability for photonic applications at high temperature or photon flux. Here we demonstrate strategies to fabricate tunable plasmonic hafnium nitride (HfN) nanoparticles.
Hydrocarbon based stabilisers for the synthesis of cross-linked poly(2-hydroxyethyl methacrylate) particles in supercritical carbon dioxide
Authors: Parilti Rahmet , Castañon Alba , Lansalot Muriel , D'Agosto Franck , Jérôme Christine , Howdle Steven M.
Published: October 2019

Novel polymeric stabilisers were designed for the development of an environmentally-friendly process to prepare well-defined cross-linked particles of poly(2-hydroxyethylmethacrylate) (PHEMA).
The effect of side-chain branch position on the thermal properties of poly(3-alkylthiophenes)
Authors: Cao Zhiqiang , Galuska Luke , Qian Zhiyuan , Zhang Song , Huang Lifeng , Prine Nathaniel , Li Tianyu , He Youjun , Hong Kunlun , Gu Xiaodan
Published: October 2019

Branching closer to the backbone causes tighter packing in the side-chain direction and lower side chain and backbone dynamics.
Decorating Ag3PO4 nanodots on mesoporous silica-functionalized NaYF4:Yb,Tm@NaLuF4 for efficient sunlight-driven photocatalysis: synergy of broad spectrum absorption and pollutant adsorption-enrichment
Authors: Liu Zongjun , Hao Juanyuan , Wang You , Sun Quan , Zhang Di , Gan Yang
Published: October 2019

A broad-spectrum photocatalyst with pollutant-adsorption capability was synthesized by decorating silver orthophosphate nanodots on mesoporous silica-functionalized upconversion nanoparticles for efficient natural sunlight-driven photocatalysis.
Electrodeposition of nanowires of a high copper content thiourea precursor of copper sulfide
Authors: Sarma Abhisakh , Dippel Ann-Christin , Gutowski Olof , Etter Martin , Lippmann Milena , Seeck Oliver , Manna Gouranga , Sanyal Milan K. , Keller Thomas F. , Kulkarni Satishkumar , Guha Puspendu , Satyam Parlapali V. , Zimmermann Martin V.
Published: October 2019

In this study we reported the pulsed electrodeposition technique of copper thiourea complex nanowires which is an important material class for application as a precursor of copper sulfide nanocrystals with potential use in solar cells, optoelectronics, medicine,etc.
In situ generated hydrophobic micro ripples via π–π stacked pop-up reduced graphene oxide nanoflakes for extended critical heat flux and thermal conductivities
Authors: Cheedarala Ravi Kumar , Song Jung Il
Published: October 2019

We report the synthesis of thermally heated pop-up reduced graphene oxide (Pop-rGO) and its nanofluid (Pop-rGO-Nf) in DI water for extended critical heat flux (CHF) in a nucleate pool boiling experiment.
Non-detergent isolation of a cyanobacterial photosystem I using styrene maleic acid alternating copolymers
Authors: Brady Nathan G. , Li Meng , Ma Yue , Gumbart James C. , Bruce Barry D.
Published: October 2019

Trimeric Photosystem I (PSI) from the thermophilic cyanobacteriumThermosynechococcus elongatus(Te) is the largest membrane protein complex to be encapsulated within a SMALP to date.
The effect of viscosity and surface tension on inkjet printed picoliter dots
Authors: Krainer Sarah , Smit Chris , Hirn Ulrich
Published: October 2019

In this study, we investigated the effect of liquid viscosity and surface tension for inkjet printing on porous cellulose sheets.
Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA
Authors: Chaix Arnaud , Cueto-Diaz Eduardo , Delalande Anthony , Knezevic Nikola , Midoux Patrick , Durand Jean-Olivier , Pichon Chantal , Cunin Frederique
Published: October 2019

Scheme of gene transfer into a cell nucleus using a porous silicon nanoparticle based non viral vector.
A closed-loop electrogenerative recycling process for recovery of silver from a diluted cyanide solution
Authors: Mohd Suah Faiz Bukhari , Teh Bee Ping , Mansor Nadia , Hamzah Hairul Hisham , Mohamed Norita
Published: October 2019

A closed-loop process for the complete recovery of silver from a diluted silver cyanide solution has been constructed based on an electrogenerative process.
Changes in magnetic order through two consecutive dehydration steps of metal-phosphonate diamond chains
Authors: Su Yan-Hui , Jia Jia-Ge , Huang Xin-Da , Feng Jian-Shen , Bao Song-Song , Ren Min , Kurmoo Mohamedally , Zheng Li-Min
Published: October 2019

M3II(hpdpH)2(H2O)6·4H2O (M = Co, Ni) experience identical two-step dehydration processes associated with drastic magnetic changes from paramagnet to antiferromagnet/metamagnetic to ferrimagnet for M = Co, and from antiferromagnet to antiferromagnet to ferrimagnet for M = Ni.
16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro
Authors: Yang Yiren , Long Liping , Zhang Xinxin , Song Kairu , Wang Da , Xiong Xin , Gao Huiyuan , Sha Luping
Published: October 2019

Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides.
TiO2 nanocrystals with the {001} and {101} facets co-exposed with MIL-100(Fe): an egg-like composite nanomaterial for efficient visible light-driven photocatalysis
Authors: Wu Wan , Zhu Jie , Deng Yue Hong , Xiang Ye , Tan Ya Wen , Tang Hai Qin , Zou Hao , Xu Yi Feng , Zhou Yi
Published: October 2019

The exposure of a specific crystal face to a specific composition and the search for a suitable carrier composition with synergistic effects can effectively improve the photocatalytic activity of the material and enhance its practical value.
d-Glucose sensor based on ZnO·V2O5 NRs by an enzyme-free electrochemical approach
Authors: Rahman Mohammed M. , Hussain Mohammad Musarraf , Asiri Abdullah M.
Published: October 2019

A simple wet-chemical technique was used to prepare zinc oxide-doped vanadium pentaoxide nanorods (ZnO·V2O5 NRs) in an alkaline environment.
Self-healing zwitterionic sulfobetaine nanocomposite hydrogels with good mechanical properties
Authors: Lin Yinlei , Zeng Zheng , Li Yuhao , Sun Sheng , Liu Xiaoting , He Deliu , Li Guangji
Published: October 2019

The prepared zwitterionic sulfobetaine nanocomposite hydrogels can autonomously repair incisions or cracks at ambient temperature without the need for any stimulus and possess excellent mechanical properties.
Observation of giant spin–orbit interaction in graphene and heavy metal heterostructures
Authors: Afzal Amir Muhammad , Min Kuen Hong , Ko Byung Min , Eom Jonghwa
Published: October 2019

We used Pb as an intercalated layer between the graphene and Au and measured the spin–orbit interaction in local and non-local measurement configurations.
Microstrain and electrochemical performance of garnet solid electrolyte integrated in a hybrid battery cell
Authors: Botros Miriam , Scherer Torsten , Popescu Radian , Kilmametov Askar , Clemens Oliver , Hahn Horst
Published: October 2019

Influence of induced microstrain due to pressure application during field assisted sintering on the electrochemical performance of Al-doped LLZO.
Synthesis and reactivity of 2-thionoester pyrroles: a route to 2-formyl pyrroles
Authors: Kim Min Joon , Gaube Sophie M. , Beh Michael H. R. , Smith Craig D. , Thompson Alison
Published: October 2019

The one-step desulfurative reduction of 2-thionoester pyrroles provides 2-formyl pyrroles, including the opportunity to access the deuterated variant.
Synergistic adsorptions of Na2CO3and Na2SiO3on calcium minerals revealed by spectroscopic andab initiomolecular dynamics studies
Authors: Foucaud Yann , Badawi Michaël , Filippov Lev O. , Barres Odile , Filippova Inna V. , Lebègue Sébastien
Published: October 2019

FTIR, XPS, andab initiomolecular dynamics studies demonstrated that sodium silicate (Na2SiO3) adsorbs on fluorite with a higher affinity when they are treated beforehand by sodium carbonate (Na2CO3) due to proton exchange(s).
Single-molecule dynamic DNA junctions for engineering robust molecular switches
Authors: Cai Shuang , Deng Yingnan , Fu Shengnan , Li Junjie , Yu Changyuan , Su Xin
Published: October 2019

Highly robust DNA molecule switches were engineered by utilizing single-molecule dynamic three-way junctions.
Bifunctional ligand design for modulating mutant p53 aggregation in cancer
Authors: Miller Jessica J. , Blanchet Anaïs , Orvain Christophe , Nouchikian Lucienne , Reviriot Yasmin , Clarke Ryan M. , Martelino Diego , Wilson Derek , Gaiddon Christian , Storr Tim
Published: October 2019

Iodination of a bifunctional ligand framework restores p53 function by interacting with and inhibiting mutant p53 aggregation.
Fabrication of rigidity and space variable protein oligomers with two peptide linkers
Authors: Choi Hyeokjune , Park Hyoin , Son Kabi , Kim Ho Min , Jung Yongwon
Published: October 2019

A new two peptide-linked protein assembly strategy was developed for diverse linker length and rigidity variation on protein oligomers.
Defect-mediated electron–hole separation in an inorganic–organic CdSxSe1−x–DETA solid solution under amine molecule-assisted fabrication and microwave-assisted method for promoting photocatalytic H2 evolution
Authors: Huo Yao , Li Zhen , Zhang Jinfeng , Dai Kai , Liang Changhao , Yang Yang
Published: October 2019

Inorganic–organic CdSxSe1−x–DETA solid solution shows high visible light photocatalytic H2 evolution activity.
In situ structure and force characterization of 2D nano-colloids at the air/water interface
Authors: Li-Destri Giovanni , Ruffino Roberta , Tuccitto Nunzio , Marletta Giovanni
Published: October 2019

We have developed a novel experimental method, which enables quantitative determination of interaction forces between interfacial nanoparticles as a function of the inter-particle distance at liquid interfaces.
Emergence of rechargeable seawater batteries
Authors: Senthilkumar S. T. , Go Wooseok , Han Jinhyup , Pham Thi Thuy Linh , Kishor Koshal , Kim Yongil , Kim Youngsik
Published: October 2019

New concepts or chemistry is an urgent requirement for rechargeable batteries to achieve a low-cost, user-friendly nature with adequate energy densities and high levels of safety.
A zinc(ii) complex of di(naphthylethynyl)azadipyrromethene with low synthetic complexity leads to OPV with high industrial accessibility
Authors: Wang Chunlai , Wei Peiran , Ngai Jenner H. L. , Rheingold Arnold L. , Gray Thomas G. , Li Yuning , Pentzer Emily , Li Ruipeng , Zhu Lei , Sauvé Geneviève
Published: October 2019

This new non-planar non-fullerene acceptor has low synthetic complexity and shows good performance with P3HT, leading to high industrial accessibility.
Concurrent photothermal therapy and photodynamic therapy for cutaneous squamous cell carcinoma by gold nanoclusters under a single NIR laser irradiation
Authors: Liu Pei , Yang Weitao , Shi Lei , Zhang Haiyan , Xu Yan , Wang Peiru , Zhang Guolong , Chen Wei R. , Zhang Bingbo , Wang Xiuli
Published: October 2019

The concurrent photothermal and photodynamic therapy of cutaneous squamous cell carcinoma by a single drug of Au25(Capt)18nanoclusters is demonstrated, together with a preliminary immune response study conducted under a single NIR laser irradiation.
Super-tough, anti-fatigue, self-healable, anti-fogging, and UV shielding hybrid hydrogel prepared via simultaneous dual in situ sol–gel technique and radical polymerization
Authors: Du Juan , She Xiaohong , Zhu Wenli , Yang Qiaoling , Zhang Huaju , Tsou Chihui
Published: October 2019

A hydrogel crosslinked by hierarchical inorganic hybrid crosslinks via simultaneous in situ sol–gel technique and radical polymerization exhibits excellent mechanical performance.
Supramolecular and dynamic covalent hydrogel scaffolds: from gelation chemistry to enhanced cell retention and cartilage regeneration
Authors: Teng Lijing , Chen Yunhua , Jia Yong-Guang , Ren Li
Published: October 2019

This review highlights the most recent progress in gelation strategies of biomedical supramolecular and dynamic covalent crosslinking hydrogels and their applications for enhancing cell retention and cartilage regeneration.
Influence of codoped Gd3+ ions on the spectroscopic site symmetry of Dy3+ ions in LaF3 single crystals
Authors: Hu Mingyuan , Wang Yan , You Zhenyu , Zhu Zhaojie , Li Jianfu , Cai Xiuyuan , Tu Chaoyang
Published: October 2019

In this paper, a series of Dy3+/Gd3+ codoped LaF3 (LDG) single crystals were grown by the Bridgman–Stockbarger method.
Achieving ultrahigh energy storage performance in bismuth magnesium titanate film capacitors via amorphous-structure engineering
Authors: Xie Juan , Liu Hanxing , Yao Zhonghua , Hao Hua , Xie Yanjiang , Li Zongxin , Cao Minghe , Zhang Shujun
Published: October 2019

Amorphous engineering can effectively tailor energy storage performances of dielectrics due to the improvement of dielectric breakdown.
High thermal conductivity property of polyamide-imide/boron nitride composite films by doping boron nitride quantum dots
Authors: Zhou Shuaishuai , Xu Tongle , Jiang Fang , Song Na , Shi Liyi , Ding Peng
Published: October 2019

In this study, we report a flexible polyamide-imide (PAI)/boron nitride nanosheet (BNNS) composite film with improved thermal conductivity by doping boron nitride quantum dots (BNQDs) using an evaporation-induced self-assembly method.
Highly efficient deep-blue light-emitting copolymers containing phenoxazine: enhanced device efficiency and lifetime by blending a hole transport molecule
Authors: He Jiajian , Huang Zhenqiang , Huang Zhiqi , Liao Shengzu , Peng Feng , Zhong Zhiming , Guo Ting , Ying Lei , Cao Yong
Published: October 2019

High efficiency and enhanced lifetime of deep-blue PLEDs were achieved by blending phenoxazine-based copolymers with a hole transport molecule.
Tunable afterglow luminescence and triple-mode emissions of thermally activated carbon dots confined within nanoclays
Authors: Deng Yuchen , Li Peng , Jiang Haiyan , Ji Xu , Li Huanrong
Published: October 2019

Tunable afterglow luminescence and interesting multi-mode emissions (fluorescence (FL), delayed fluorescence (DF), and room-temperature phosphorescence (RTP)) via excitation wavelength and temperature variations were achieved.
An A–D–D–A-type non-fullerene small-molecule acceptor with strong near-infrared absorption for high performance polymer solar cells
Authors: Tan Hua , Zheng Xiangjun , Zhu Jianing , Yu Junting , Zhu Weiguo
Published: October 2019

An A–D–D–A-type near-infrared non-fullerene small-molecule acceptor IDT2-DFIC with indacenodithiophene–indacenodithiophene (IDT2) as donating core and 2-(5,6-difluoro-3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile (2FIC) as electron withdrawing end groups has been synthesized.
Family Involvement in Adult Hearing Evaluation Appointments: Patient Perspectives
Authors: Reynolds Bailey , Yoho Sarah E. , Muñoz Karen , Pitt Cache
Published: October 2019

Background

Many adults suffer from an array of consequences due to their hearing loss (e.g., self-efficacy, mastery, psychosocial challenges). Family involvement can help improve their outcomes.

Purpose

This study aimed to determine audiology adult patients hearing experiences and inquired about their perspectives on family involvement in appointments.

Research Design

A cross-sectional survey was completed. Descriptive statistics, item analyses, and quantitative analyses were used to examine patient's characteristics and perspectives.

Study Sample

Three hundred eighty-two adult audiology patients participated in the study.

Data Collection and Analysis

A 15-item survey was created with 4 sections, including patient demographic information, general hearing questions, hearing experiences, and family interactions and involvement. Descriptive statistics were used to examine patient's characteristics and perspectives on family involvement in audiology appointments. Chronbach's alpha was used to reveal good internal consistency of difficult feelings related to hearing and perceived negative family member reactions. Quantitative analyses were used to determine patient perspectives on family involvement.

Results

Though patients reported difficulties due to their hearing loss, more than half reported that they did not want family involvement or they were unsure of the benefit that the involvement would provide. Patients who were interested in having family involved reported benefits such as educational opportunities and support. Few barriers of family involvement were reported by patients.

Conclusions

Patients had a mixed desire about family involvement in their adult audiology appointments. Education of patients about the benefits of family involvement may need to happen for this shift in audiologic practice.
Perception of Sibilants by Preschool Children With Overt and Covert Sound Contrasts
Authors: Roepke Elizabeth , Brosseau-Lapré Françoise
Published: October 2019

Purpose

This study explores the role of overt and covert contrasts in speech perception by children with speech sound disorder (SSD).

Method

Three groups of preschool-aged children (typically developing speech and language [TD], SSD with /s/~/ʃ/ contrast [SSD-contrast], and SSD with /s/~/ʃ/ collapse [SSD-collapse]) completed an identification task targeting /s/~/ʃ/ minimal pairs. The stimuli were produced by 3 sets of talkers: children with TD, children with SSD, and the participant himself/herself. We conducted a univariate general linear model to investigate differences in perception of tokens produced by different speakers and differences in perception between the groups of listeners.

Results

The TD and SSD-contrast groups performed similarly when perceiving tokens produced by themselves or other children. The SSD-collapse group perceived all speakers more poorly than the other 2 groups of children, performing at chance for perception of their own speech. Children who produced a covert contrast did not perceive their own speech more accurately than children who produced no identifiable acoustic contrast.

Conclusion

Preschool-aged children have not yet developed adultlike phonological representations. Collapsing phoneme production, even with a covert contrast, may indicate poor perception of the collapsed phonemes.
Similar shot profile morphology of fast variability in a cataclysmic variable, X-ray binary, and blazar: The MV Lyrae case
Authors: Dobrotka A. , Negoro H. , Mineshige S.
Published: October 2019

Context. The cataclysmic variable MV Lyr has been found to be present in the Kepler field, yielding a light curve with the duration of almost 1500 days with 60 s cadence. Such high quality data of this nova-like system with obvious fast optical variability reveal multi-component power density spectra, as shown by previous works.

Aims. Our goal is to study the light curve from a different point of view and perform a shot profile analysis. We search for characteristics that have not been discovered with standard methods based on power density spectrum.

Methods. The shot profile method identifies individual shots in the light curve and averages these shots to reveal all substructures with typical timescales. We also tested the robustness of our analysis using a simple shot noise model. Although the principle of this method is not completely physically correct, we used it as a purely phenomenological approach.

Results. We obtain mean profiles with multi-component features. The shot profile method distinguishes substructures with similar timescales which appear as a single degenerate feature in power density spectra. Furthermore, this method yields the identification of another high frequency component in the power density spectra of Kepler and XMM-Newton data that have not been detected so far. Moreover, we found side lobes accompanied with the central spike, making the profile very similar to the Kepler data of blazar W2R 1926+42 and the Ginga data of Cyg X-1. All three objects show similar timescale ratios of the rising versus declining part of the central spikes, while the two binaries also have similar rising profiles of the shots described by a power-law function.

Conclusions. The similarity of both binary shot profiles suggests that the shots originate from the same origin, namely, aperiodic mass accretion in the accretion disc. Moreover, the similarity with the blazar may imply that the ejection fluctuations in the blazar jet are connected to accretion fluctuations driving the variability in binaries. This points out the connection between the jet and the accretion disc.
Penser l’éthique des curriculums de formation professionnelle en santé au regard d’une perspective épistémologique de « l’agir-en-santé »
Authors: Parent Florence , Aiguier Grégory , Berkesse Alexandre , Reynaerts Manoé , Rolland Franck , Wardavoir Helyett , Jouquan Jean ,   au nom des membres du réseau thématique « Éthique des curriculums en santé » de la Société internationale francophone d’éducation médicale (SIFEM)
Published: October 2019

Problématique :Plusieurs mouvements tentent de reformuler les fondements d’une clinique en tant quepraxis, centrée sur un « agir-en-santé » : promotion de la santé, soins palliatifs, éducation thérapeutique du patient, médecine centrée sur le patient, courant du patient-partenaire, humanités et sciences humaines et sociales pour la santé, etc.. Ils s’efforcent d’apporter leurs contributions propres à la redéfinition de la santé et à sa traduction en tant qu’objet d’enseignement et d’apprentissage dans les curriculums de formation des professionnels de la santé.Exégèse :Les auteurs proposent la notion d’éthique des curriculums en santé pour désigner l’idée que les choix alternatifs relatifs aux conceptions de l’agir en santé, qui sous-tendent l’organisation des curriculums de formation des professionnels de la santé, devraient être rendus explicites au regard des dimensions constitutives d’un paradigme en philosophie des sciences (ontologique, épistémologique et méthodologique), dans le cadre de processus démocratiques de mise en projet.Conclusion :En lien avec une telle perspective, les auteurs argumentent qu’il est possible et nécessaire de caractériser l’agir professionnel en santé en tant que nouvel objet d’enseignement et d’apprentissage, au regard des trois dimensions, respectivement en privilégiant la centralité de l’action, en invitant à une rupture pragmatiste et à un élargissement gnoséologique et méthodologique, et en exploitant le concept de compétence à des fins didactiques et pédagogiques, dans le cadre de processus démocratiques de mise en projet, en favorisant une participation et une représentativité interdisciplinaires et interprofessionnelles. Une telle démarche est de nature éthique.
On baer-nunziato multiphase flow models
Authors: Hillairet M.
Published: October 2019

In these notes, we present an analytical tool for the derivation of Baer-Nunziato multiphase flow systems with one velocity. We explain the method in the case of the isentropic Navier Stokes equations. We then apply this method to models with temperature and show the main computations which are necessary to the derivation.
Intraductal temperature-controlled radiofrequency ablation in malignant hilar obstruction: a preliminary study in animals and initial human experience
Authors: Kim Eui Joo , Cho Jae Hee , Kim Yoon Jae , Lee Tae Hoon , Kim Joon Mee , Jeong Seok , Kim Yeon Suk
Published: October 2019

Background and study aims Intraductal radiofrequency ablation (ID-RFA) is a recently developed method widely used for treatment of malignant extrahepatic biliary tract obstructions. However, its safety in hilar application has yet to be clearly demonstrated. The aim of this study was to evaluate the safety of ID-RFA in the treatment of malignant hilar obstruction.

Patients and methods Endoscopic retrograde cholangiography followed by temperature-controlled ID-RFA at the hilar area using different probe lengths (11, 18, and 22 mm) and settings (7 or 10 W for 60 – 120 s) was performed in six mini-pigs. In addition, patients with malignant hilar obstruction who underwent palliative ID-RFA were retrospectively evaluated.

Results In the animal study using different ID-RFA settings, post-ID-RFA fluoroscopic radiocontrast leakage and microscopic bile duct perforation with hepatic abscess were observed in four of the six mini-pigs. Only two of the them, in which an 11-mm ID-RFA probe at a target temperature of 80 °C, power of 7 W, and duration of 60 s was used, underwent successful ID-RFA without any immediate adverse events (AEs). Clinically, ID-RFA was performed using the 11-mm probe with the setting of 80 °C, 7 W, and 60 – 120 s for malignant hilar obstruction, and total of 11 patients underwent successful ID-RFA without AEs.

Conclusions Our study suggests that ID-RFA performed using a short-length probe with settings of 80 °C, 7 W and 60 – 120 s is a safe and feasible palliative treatment for malignant hilar obstruction.
Effects of Interrupting Sitting with Use of a Treadmill Desk Versus Prolonged Sitting on Postural Stability
Authors: Charalambous Laura H. , Champion Rachael B. , Smith Lindsey R. , Mitchell Andrew C. S. , Bailey Daniel P.
Published: October 2019

High amounts of sitting increase the risk of non-communicable disease and mortality. Treadmill desks make it possible to reduce sitting during the desk-based workerʼs day. This study investigated the acute effect on postural stability of interrupting prolonged sitting with an accumulated 2-h of light-intensity treadmill desk walking. Twenty-one sedentary adults participated in this randomized acute crossover trial, with two 6.5 h conditions: 1) uninterrupted sitting and 2) interrupted sitting with accumulated 2 h light-intensity treadmill desk walking. Pre- and post-condition, participants performed four postural stability tests on a pressure plate (bipedal and unipedal standing stance, eyes open and eyes closed). Anteroposterior center of pressure amplitude showed a significant condition x time interaction in bipedal eyes closed (F(1,20)=4.62, p=0.046) and unipedal eyes open (F(1,20)=9.42, p=0.006) tests, and mediolateral center of pressure amplitude in bipedal eyes closed (F(1,20)=6.12, p=0.023) and bipedal eyes open (F(1,12)=5.55, p=0.029) tests. In the significant interactions, amplitude increased pre to post condition in the uninterrupted sitting condition. The accumulated 2 h light-intensity treadmill desk walking ameliorated the negative effect of 6.5 h prolonged sitting on postural sway, supporting workplace treadmill desk use.
Elternsein nach extremer Frühgeburt – die Katastrophe
überstehen
Authors: Söhngen Julia , Schnepp Wilfried
Published: October 2019

Eltern von extrem Frühgeborenen erleben die ersten Wochen nach der Geburt ihres
Kindes auf einer neonatologischen Intensivstation. Häufig verbringen sie dort
mehrere Monate und erleben eine Vielzahl von traumatischen Ereignissen. Die
Mütter und Väter dieser extrem kleinen Kinder beschreiben in dieser Untersuchung
ihre Ängste vor dem Tod und vor gravierenden bleibenden Beeinträchtigungen ihrer
Kinder. Wie die Eltern diese Zeit überstehen und welche Strategien sie dabei
entwickeln, wurde mithilfe von Beobachtungen und Interviews untersucht.
Unraveling the Molecular Basis for Successful Thyroid Hormone
Replacement Therapy: The Need for New Thyroid Tissue- and Pathway-Specific
Biomarkers
Authors: Nock Sebastian , Höfig Carolin , Harder Lisbeth , Schomburg Lutz , Brabant Georg , Mittag Jens
Published: October 2019

Thyroid function is conventionally assessed by measurement of thyroid-stimulating
hormone (TSH) and free circulating thyroid hormones, which is in most cases
sufficient for correct diagnosis and monitoring of treatment efficiency.
However, several conditions exist, in which these parameters may be insufficient
or even misleading. For instance, both, a TSH-secreting pituitary adenoma and a
mutation of thyroid hormone receptor β present with high levels of TSH
and circulating hormones, but the optimal treatment is substantially different.
Likewise, changes in thyroid hormone receptor α signaling are not
captured by routine assessment of thyroid status, as serum parameters are
usually inconspicuous. Therefore, new biomarkers are urgently needed to improve
the diagnostic management and monitor treatment efficiency for e. g.,
replacement therapy in hypothyroidism or thyroid hormone resistance. By
comparing animal models to human data, the present minireview summarizes the
status of this search for new tissue- and pathway-specific biomarkers of thyroid
hormone action.
Ossified Occipital Pseudomeningocele following Ventriculoperitoneal Shunt Malfunction
Authors: Bhatt Anusha S. , Mishra Ajit M. , Mhatre Radhika , Nandeesh Bevinahalli N.
Published: October 2019

Ossification of pseudomeningocele is a rare occurrence and is one of the rare complications of ventriculoperitoneal (VP) shunt malfunction. We report a case of 12-year-old boy who came with features of raised intracranial pressure following shunt malfunction which was placed as a treatment to the aqueductal stenosis. Computed tomography showed ventriculomegaly and hypodense collection in the occiput with posterior rim of calcification. The findings were confirmed on histopathology. Although ossified pseudomeningocele is a rare entity following VP shunt placement, it should be suspected if patients present with aggravated symptoms, especially if there is shunt malfunction as the treatment option varies with the presence or absence of resultant symptoms and ossification.
Optimizing Burr Hole Placement for Craniotomy: A Technical Note
Authors: Rai Survendra Kumar Rajdeo , Dandpat Saswat Kumar , Jadhav Dikpal , Ranjan Shashi , Shah Abhidha , Goel Atul H.
Published: October 2019

Objective Usually, burr holes are placed along the line of a craniotomy. We describe a novel technique of burr hole placement to obtain smooth and beveled bony margin without any troughs and crests. Dural separation is obtained by minimizing the number
of burr holes required.

Methods Fifty craniotomies of diameter ranging from 3.5 to 11.5 cm were accomplished by placing burr hole in the center of bone flap rather than along the craniotomy line permitting 360 degrees of dura separation dependent on the length of dura separator. Craniotomy < 9  cm in diameter was performed by placing a single burr hole and a larger size craniotomy was performed with two burr holes. Parasagittal craniotomy was performedby placing burr hole not > 2.5  cm away from expected craniotomy site, namely superior sagittal sinus area enabling separation of adhered dura and venous sinuses. The bone cutter was used in a particular fashion to create smooth margin and beveled edges.

Results Craniotomy < 9  cm in diameter was possible with single burr hole in 34 cases. Craniotomy larger than 9  cm in size was performed in 16 cases with double burr hole by strategically placing burr in the center of the desired bone flap. The craniotomy was achieved in all cases without damaging dura and venous structures.

Conclusions An optimally placed single burr hole is sufficient for small to moderately large size craniotomy. Larger size craniotomy is possible with minimum numbers of burr holes. This achieves good cosmesis and avoids sinking of the bone flap.
Persistent Enlarged Occipital Sinus with Absent Unilateral Transverse Sinus
Authors: Satyarthee Guru Dutta , Moscote-Salazar Luis Rafael , Agrawal Amit
Published: October 2019

The occipital sinus may occasionally remain patent, but the incidence is extremely low and observed in less than 10% of cases. A persistent patent occipital sinus (POS) may be associated with other venous sinus abnormality. The absence of transverse sinus in association with POS is an extremely rare condition and not reported yet. The neuroradiologist, neurosurgeons, otolaryngologist, and neurologist must be aware of the possible existence of POS and other associated venous sinus anomaly, as its warrants very crucial modification of surgical planning, selection of appropriate approaches, and, additionally, may also critically limit the extent of surgical exposure of target, and may hinder intended extent of surgical excision of tumor and associated possibility of injury to POS, which may produce catastrophic hemorrhage, brain swelling, and neurosurgical morbidity. The authors report a 35-year-old male who underwent suboccipital craniotomy for right-side giant acoustic schwannoma. Following the raising bone flap, a markedly prominent, turgid, occipital sinus was observed, not placed exactly in the midline but deviated to the right side, causing further restraining of dural opening. Surgical nuances and intraoperative difficulty encountered along with pertinent literature is reviewed briefly.