bluuebunny/crossref_metadata_2025 huggingface dataset:
Spleen arterial vascularization in fur-bearing animals in cages
Authors:   Omsk State Agrarian University named after P.A. Stolypin, Ovchinnikov Dmitriy K. , Grechko Viktor V. ,   Omsk State Agrarian University named after P.A. Stolypin
Published: December 2020

The spleen is an unpaired parenchymal organ located in the abdominal cavity, performing immunological, filtration and hematopoietic functions and, in connection with the listed functional features, plays an essential role in the organism. Authors obtained detailed information on the arterial vascularization of the spleen of fur-bearing animals of Carnivora, since the information available in the special literature on the morphological aspects of the blood supply of the named organ is fragmentary. A comprehensive study of the spleen was carried out, which made it possible to confirm the general morphological patterns, to reveal the characteristic specific and intraspecific features of the vascularization of the spleen in fur-bearing animals in cages. The new data obtained on the morphology of the vessels vascularizing the spleen are original and give a complete picture of the organ. Analyzing the material obtained from own research, and comparing it with information from special literature, allows to assert that the blood supply to the spleen in fur-bearing animals of cellular content (silver-black fox, blue fox, sable and American mink) is carried out through the splenic artery, which also gives off branches to the stomach, pancreas and great omentum. If in the methods of branching of the splenic artery in the studied animals we note a great similarity, then in the number of branches branching from it there are significant differences. As a result of the study, it was found that the spleen is vascularized by the splenic artery extending from the celiac artery.
Frequency and Sociodemographic Characteristics of Urinary Incontinence in Patients Over 65 Years of Age in Rural of Turkey
Authors: Kizmaz Muhammet , Kumtepe Kurt Burcu , Cetin Kargin Nisa , Doner Ezgi
Published: December 2020

Aim: The aim of this study was to determine the prevalence of urinary incontinence in patients over 65 years of age and to investigate its relationship with sociodemographic characteristics.

Methods: This study is a cross-sectional descriptive study performed using a face to face survey and conducted between the dates of May 1st, 2019 and August 1st, 2019 in patients aged 65 and above and who applied to Gemerek State Hospital Family Medicine Outpatient Clinics. Following a literature search, the questionnaire developed by the investigators was applied.

Results: The prevalence of UI was 28.5%. Among those, 43.8% alone had not presented to any physician with this complaint. Among the patients with UI who refrained to tell this complaint to their physicians, 76% considered this condition as a natural consequence of ageing, 17.4% were shy to get examined and 6.6% told that they had no discomfort to have a UI. Among the patients, 72.9% (n=269) were never asked by a physician or a nurse whether they had experienced UI.

Conclusions: The symptoms of urinary incontinence are generally considered as a reflection of ageing or patients are shy to express this complaint. In addition, the rate of questioning about urinary incontinence by the physicians or nurses seems to be very low.

Keywords: geriatrics, urinary incontinence, aging
Rapid Antigen Detection Test Using Rates of Family Physicians, Test Results and Its Impact on Their Prescription Behaviours
Authors: Aslaner Humeyra , Aslaner Haci Ahmet , Ertürk Arik Bade , Onuk Fahri Alpay , Benli Ali Ramazan , Mistik Selcuk
Published: December 2020

Aim: The aim of this study is to determine the rates of rapid antigen detection test use, test results and its relationship with Modified Centor Score and investigate the effect of rapid antigen detection test use on prescribing behaviour.

Methods: This research was conducted by scanning the family physicians’ information system retrospectively. From the Family Medicine Information System, where polyclinics and prescription records of the family health centers where 12 family physicians work in Kayseri are located, the number and results of rapid antigen detection tests performed between February 2017 and April 2019, the Modified Centor Score automatically calculated by the system, the number of prescribed antibiotics and symptomatic treatment information was recorded.

Results: The positivity of rapid antigen detection test was considered, cut-off value of Modified Centor Score was >2 (ROC EAA:63.9, Cl:0.95,0.61-0.66). Sensitivity rate of the test for diagnostic score was 86% and selectivity rate was 48.8%.

Conclusion: Family physicians should be encouraged to use rapid antigen detection test. The fact that antibiotics are prescribed in rapid antigen detection testnegative patients may indicate that confidence level of the test is less than physical examination and clinical findings.

Keywords: sore throat, primary care, score
Occurrence and Functions of Endophytic Fungi in Crop Species
Authors: Nicoletti Rosario
Published: December 2020

After having been initially boosted by the general aim to exploit biodiversity in natural environments, research on endophytic microorganisms has recently started considering their occurrence in crop species [...]
Kochia (Kochia scoparia) and Wild Oat (Avena fatua) Intraspecific and Interspecific Interference
Authors: Sharpe Shaun M.
Published: December 2020

Kochia (Kochia scoparia) and wild oat (Avena fatua) are highly problematic western Canadian weeds. Wild oat is widely distributed and has been a long-standing agricultural pest across Manitoba, Saskatchewan, and Alberta. Kochia populations are patchy and occur more frequently within the southern regions of the Prairie provinces. Kochia is exhibiting an ever-evolving, aggressive, herbicide resistance survival strategy which may facilitate range expansion. The experimental objective was to study the interspecific and intraspecific interference between wild oat and kochia. The study was developed with the context of kochia tumbleweeds travelling and depositing seed within wild oat infestations. Greenhouse experiments were conducted in Saskatoon, SK. The experimental design was a two factor factorial arranged as a randomized complete block. The main factors were kochia and wild oat pot density at either 0, 1, or 2 plants per pot. Treatment combinations resulted in species ratios of 1:1, 2:1, 1:2, and 2:2, with single species controls. Kochia biomass was reduced by >70% after 3 months of competition with a single wild oat plant. Wild oat biomass was consistently impacted by intraspecific competition, demonstrating a 25 to 50% reduction at the trial end. Kochia interspecific interference with wild oat at a 2:1 ratio did reduce wild oat biomass by 50% but this trend was not consistent across experimental runs. Kochia dispersal through wild oat infestations should induce competitive stress when crop competition is considered. Three-species interference patterns to include western Canadian crops require additional study.
Evaluation of the Contribution of Pastures on the Economic Sustainability of Small Ruminant Farms in a Typical Greek Area
Authors: Papadopoulou Artemis , Ragkos Athanasios , Theodoridis Alexandros , Skordos Dimitrios , Parissi Zoi , Abraham Eleni
Published: December 2020

Small ruminant production is predominantly linked to the use of natural pastures; however the intensification process in past decades has led to a gradual abandonment of grazing and the prevalence of intensive patterns. This paper contributes to the discussion about the economic performance of small ruminant farms relative to the use of pastures. Using data from a sample of Greek sheep and goat farms it is shown that grazing does not necessarily increase economic performance. If not organized carefully, farms which graze more do not reduce their feeding costs or they counterbalance this reduction with increases labor expenses. An efficiency analysis of the sample using Data Envelopment Analysis (DEA) shows that farms which graze less are generally more efficient than the ones which graze more. Furthermore, the input-oriented DEA model reveals that the same level of output could be achieved with less a reduction of hours grazing by 12.5% and 11.9%, respectively for farms which graze less than 1800 h and more than 1800 respectively. It is concluded that a higher level of organization is required to render grazing a practice with positive economic impact on farms, including infrastructure for better accessibility of pastures, more efficient rations and training. This applies also to the framework for pasture use in Greece, as the delivery of Integrated Grazing Management Plans is expected to provide guidance and stability to small ruminant farmers.
Early Shoot Development Affects Carbohydrate Supply and Fruit Quality of Red-Fleshed Actinidia chinensis var. chinensis ‘Zes008’
Authors: Richardson Annette , Eyre Victoria , Kashuba Peggy , Ellingham Deborah , Jenkins Heather , Nardozza Simona
Published: December 2020

Fruit quality characteristics are highly variable across kiwifruit vines due to complex source-sink interactions. We investigated how variation in fruit quality of Actinidia chinensis (Planch.) var. chinensis ‘Zes008’ was influenced by different shoot types (short, medium or long) and rootstocks types (Actinidia chinensis (Planch.) var. deliciosa (A. Chev.) ‘Bruno’ or Actinidia macrosperma C.F. Liang). Short shoots had smaller leaves (−30 to −50%) and lower photosynthesis rates (−0.70 to −3.34 µmol m−2 s−1) in the first cluster of nine leaves (Zone 1) compared with leaves on medium or long shoots. Later in the season, photosynthesis rates in Zone 1 declined with leaf age, but photosynthesis rates were higher (+0.5 to +6.1 µmol m−2 s−1) in later developing leaves on medium or long shoots. Fruit from short shoots had lower dry matter (−0.3 percent units) and lower outer pericarp flesh red pigment scores than fruit from medium or long shoots. At harvest, fruit from vines on ‘Bruno’ rootstocks were larger (+3.7 g), had higher dry matter (+1.3 percent units), soluble solids concentration (+1.7° Brix) and firmness (+0.4 kgf) than fruit from vines on A. macrosperma rootstocks. Factors that prioritised early development of source leaves had a direct impact on the carbohydrate supply from photosynthesis to support flower and fruit development.
Fractionation and Hydrolyzation of Avocado Peel Extract: Improvement of Antibacterial Activity
Authors: Trujillo-Mayol Igor , Casas-Forero Nidia , Pastene-Navarrete Edgar , Lima Silva Fabiana , Alarcón-Enos Julio
Published: December 2020

Avocado Hass (Persea americana Mill) peel extract (APE) has the potential as a natural ingredient to substitute for chemical preservatives. The objectives of this study were to assess the phytochemical composition by high-performance liquid chromatography–quadrupole time-of-flight mass/mass spectrometry (HPLC-qTOF-MS/MS), total phenolic content (TPC), proanthocyanidin (PAC) content, and antioxidant activity of the APE, the organic fraction (OF), the aqueous fraction (AF), and the acid-microwave hydrolyzed APE (HAPE), on the antibacterial activity (ABA). The results indicated that APE and OF contained (p ˂ 0.05) a higher phenolic composition and antioxidant activity than AF and HAPE. The ABA specified that Pseudomonas aeruginosa and Bacillus cereus were inhibited by all the extracts (minimal inhibitory concentration—MIC ≥ 500 µg/mL), Staphylococcus aureus was only significantly inhibited by APE (≥750 µg/mL), the same MIC was observed for the OF on Salmonella spp. and Listeria monocytogenes. The HAPE increased the inhibitory efficiency up to 25% on Escherichia coli and Salmonella spp. (MIC ≥ 750 µg/mL), and 83.34% on L. monocytogenes (MIC ≥ 125 µg/mL) compared to APE (MIC ≥ 750 µg/mL). Also, HAPE inhibited the biofilm formation at the lowest concentration (125 µg/mL); meanwhile, the biofilm disruption showed to be concentration-time-dependent (p ˃ 0.05) compared to amoxicillin. In conclusion, the fractionation and hydrolyzation of APE improved the ABA; thus, those strategies are useful to design new antimicrobial compounds.
Long-Term Consumption of Anthocyanin-Rich Fruit Juice: Impact on Gut Microbiota and Antioxidant Markers in Lymphocytes of Healthy Males
Authors: Groh Isabel Anna Maria , Riva Alessandra , Braun Dominik , Sutherland Heidi G. , Williams Owen , Bakuradze Tamara , Pahlke Gudrun , Richling Elke , Haupt Larisa M. , Griffiths Lyn R. , Berry David , Marko Doris
Published: December 2020

Polyphenols are considered protective against diseases associated with oxidative stress. Short-term intake of an anthocyanin-rich fruit juice resulted in significantly reduced deoxyribonucleic acid (DNA) strand-breaks in peripheral blood lymphocytes (PBLs) and affected antioxidant markers in healthy volunteers. Consequently, effects of long-term consumption of fruit juice are of particular interest. In focus was the impact on nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2), the Nrf2-regulated genes NAD(P)H quinone oxidoreductase 1 (NQO-1) and heme oxygenase 1 (HO-1) as well as effects on the gut microbiota. In a nine-week placebo-controlled intervention trial with 57 healthy male volunteers, consumption of anthocyanin-rich juice significantly increased NQO-1 and HO-1 transcript levels in PBLs compared to a placebo beverage as measured by real-time polymerase chain reaction (PCR). Three Nrf2-promotor single nucleotide polymorphisms (SNPs), analyzed by pyrosequencing, indicated an association between individual Nrf2 transcript levels and genotype. Moreover, the Nrf2 genotype appeared to correlate with the presence of specific microbial organisms identified by 16S-PCR and classified as Spirochaetaceae. Furthermore, the microbial community was significantly affected by the duration of juice consumption and intake of juice itself. Taken together, long-term consumption of anthocyanin-rich fruit juice affected Nrf2-dependent transcription in PBLs, indicating systemic effects. Individual Nrf2 genotypes may influence the antioxidant response, thus requiring consideration in future intervention studies focusing on the Nrf2 pathway. Anthocyanin-rich fruit juice had an extensive impact on the gut microbiota.
Antioxidant and Chemopreventive Effect of Aliophen® Formulation Based on Malts and Hops
Authors: Tedesco Idolo , Spagnuolo Carmela , Bilotto Stefania , Izzo Angelo A. , Borrelli Francesca , Rigano Daniela , Russo Maria , Tarricone Fabrizio , Russo Gian Luigi
Published: December 2020

Experimental and clinical studies evidenced the health effects of moderate consumption of beer, mainly due to the presence of bioactive compounds, such as polyphenols, vitamins, or fibers. To exploit the potential beneficial effect on health and in disease prevention of these compounds, a new beverage based on barley malts and hops named Aliophen® has been designed, through a patented production process, with a high total polyphenolic amount compared to alcohol-free beer and similar to the one present in light and dark beers. In the present study, the antioxidant activity of Aliophen® against low-density lipoprotein (LDL) oxidation and its ability to protect erythrocytes from hemolysis have been characterized. Moreover, the chemopreventive effect of Aliophen® against colon cancer has been assessed, employing a mouse model of chemically induced carcinogenesis using azoxymethane (AOM). Data obtained showed that Aliophen at a low dose (3 mg/kg) inhibited the formation of preneoplastic lesions, polyps, and tumors. At higher doses (300 mg/kg) the protective effect was measured in the first phase of the onset of cancer. The antioxidant properties of Aliophen® were also observed in AOM-treated mice where it increased the serum antioxidant capacity. Based on the data presented, Aliophen® can exert promising health effects, including an anticancer capacity presumably associated with its antioxidant properties.
Inhibitory Effect of Antidesma bunius Fruit Extract on Carbohydrate Digestive Enzymes Activity and Protein Glycation In Vitro
Authors: Aksornchu Pattamaporn , Chamnansilpa Netima , Adisakwattana Sirichai , Thilavech Thavaree , Choosak Charoonsri , Marnpae Marisa , Mäkynen Kittana , Dahlan Winai , Ngamukote Sathaporn
Published: December 2020

Antidesma bunius (L.) spreng (Mamao) is widely distributed in Northeastern Thailand. Antidesma bunius has been reported to contain anthocyanins, which possess antioxidant and antihypertensive actions. However, the antidiabetic and antiglycation activity of Antidesma bunius fruit extract has not yet been reported. In this study, we investigated the inhibitory activity of anthocyanin-enriched fraction of Antidesma bunius fruit extract (ABE) against pancreatic α-amylase, intestinal α-glucosidase (maltase and sucrase), protein glycation, as well as antioxidant activity. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) chromatogram revealed that ABE contained phytochemical compounds such as cyanidin-3-glucoside, delphinidin-3-glucoside, ellagic acid, and myricetin-3-galactoside. ABE inhibited intestinal maltase and sucrase activity with the IC50 values of 0.76 ± 0.02 mg/mL and 1.33 ± 0.03 mg/mL, respectively. Furthermore, ABE (0.25 mg/mL) reduced the formation of fluorescent AGEs and the level of Nε-carboxymethyllysine (Nε-CML) in fructose and glucose-induced protein glycation during four weeks of incubation. During the glycation process, the protein carbonyl and β-amyloid cross structure were decreased by ABE (0.25 mg/mL). In addition, ABE exhibited antioxidant activity through DPPH radical scavenging activity and Trolox equivalent antioxidant capacity (TEAC) with the IC50 values 15.84 ± 0.06 µg/mL and 166.1 ± 2.40 µg/mL, respectively. Meanwhile, ferric reducing antioxidant power (FRAP) showed an EC50 value of 182.22 ± 0.64 µg/mL. The findings suggest that ABE may be a promising agent for inhibiting carbohydrate digestive enzyme activity, reducing monosaccharide-induced protein glycation, and antioxidant activity.
Mechanical Fracture and Fatigue Characteristics of Fine-Grained Composite Based on Sodium Hydroxide-Activated Slag Cured under High Relative Humidity
Authors: Šimonová Hana , Kucharczyková Barbara , Bílek Vlastimil , Malíková Lucie , Miarka Petr , Lipowczan Martin
Published: December 2020

A typical example of an alternative binder to commonly used Portland cement is alkali-activated binders that have high potential as a part of a toolkit for sustainable construction materials. One group of these materials is alkali-activated slag. There is a lack of information about its long-term properties. In addition, its mechanical properties are characterized most often in terms of compressive strength; however, it is not sensitive enough to sufficiently cover the changes in microstructure such as microcracking, and thus, it poses a potential risk for practical utilization. Consequently, the present study deals with the determination of long-term mechanical fracture and fatigue parameters of the fine-grained composites based on this interesting binder. The mechanical fracture parameters are primarily obtained through the direct evaluation of fracture test data via the effective crack model, the work-of-fracture method, the double-K fracture model, and complemented by parameter identification using the inverse analysis. The outcome of cyclic/fatigue fracture tests is represented by a Wöhler curve. The results presented in this article represent the complex information about material behavior and valuable input parameters for material models used for numerical simulations of crack propagation in this quasi-brittle material.
Track Modulus Assessment of Engineered Interspersed Concrete Sleepers in Ballasted Track
Authors: Lima Arthur de Oliveira , Dersch Marcus S. , Lee Jaeik , Edwards J. Riley
Published: December 2020

Ballasted railway track is typically constructed using sleepers that are manufactured from a common material type within a given length of track. Timber and concrete are the two most common sleeper materials used internationally. Evidence from historical installations of interspersed concrete sleepers in timber sleeper track in North America has indicated inadequate performance, due largely to the heterogeneity in stiffnesses among sleepers. Theoretical calculations reveal that interspersed installation, assuming rigid concrete sleepers and supports, can result in rail seat forces more than five times as large as the force supported by the adjacent timber sleepers. Recently, engineered interspersed concrete (EIC) sleepers were developed using an optimized design and additional layers of resiliency to replace timber sleepers that have reached the end of their service lives while maintaining sleeper-to-sleeper stiffness homogeneity. To confirm that the concrete sleepers can successfully replicate the stiffness properties of the timber sleepers installed in track, field instrumentation was installed under revenue-service train operations on a North American commuter rail transit agency to measure the wheel–rail vertical loads and track displacement. The results indicated that there are minimal differences in median track displacements between timber (2.26 mm, 0.089 in.) and EIC sleepers (2.21 mm, 0.087 in). Using wheel-load data and the corresponding track displacements associated with each wheel load, track modulus values were calculated using the single-point load method based on beam on elastic foundation (BOEF) fundamentals. The calculated values for the track modulus indicated similar performances between the two sleeper types, with median values of 12.95 N/mm/mm (1878 lbs./in./in.) and 12.79 N/mm/mm (1855 lbs./in./in.) for timber sleepers and EIC sleepers, respectively. The field results confirmed the suitability of the new EIC sleeper design in maintaining a consistent track modulus for the location studied, thus evenly sharing loads between and among sleepers manufactured from both concrete and timber.
Bi-Objective Design and Management of Reconfigurable Manufacturing Systems to Optimize Technical and Ergonomic Performances
Authors: Bortolini Marco , Botti Lucia , Galizia Francesco Gabriele , Regattieri Alberto
Published: December 2020

In the last decades, Reconfigurable Manufacturing Systems (RMSs) rose as an emerging manufacturing strategy matching the modern industrial and market requirements asking for a wide variety of products in flexible batches. A traditional reconfigurable manufacturing environment consists of dynamic cells, called Reconfigurable Machine Cells (RMCs), including a set of machines called Reconfigurable Machine Tools (RMTs). Such machines are characterized by fixed elements, i.e., basic modules, and dynamic elements, i.e., auxiliary modules, allowing them to perform different operations. Despite their automation level, these systems require the intervention of the human operators in performing specific tasks, e.g., handling of the auxiliary modules from the warehouse to the RMTs and their assembly/disassembly to/from the RMTs. This issue rises relevant ergonomic and safety questions due to the human–machine collaboration. Following this stream, this paper proposes and applies a bi-objective optimization model for the design and management of RMSs. The technical objective function minimizes the reconfiguration time, i.e., the time needed to equip the RMTs with the required auxiliary modules, and the part and auxiliary module travel time among the RMCs. The ergonomic objective function minimizes the repetitive movements performed by the human operators during the working activities according to the ISO 11228-3 standard. Results show the existence of a good trade-off between the two objective functions, proving the possibility to improve the ergonomic conditions of the human operators without excessively increasing the total time needed for RMTs reconfiguration and for part and auxiliary module travelling.
GNSS Applications to Assess Performance in Olympic Sailors: Laser Class
Authors: Caraballo Israel , Conde-Caveda Julio , Pezelj Luka , Milavić Boris , Castro-Piñero José
Published: December 2020

Laser class is an Olympic sport in which technical and tactical variables are very important in the performance of the sailor. However, the variables that determine performance in a regatta have not been studied, and less so with Olympic sailors. Therefore, the main objectives of this study are to analyze the technical and tactical variables that differentiate sailors based on their level of performance and sex and determine the most important courses in a regatta. The sample consists of 159 Olympic sailors (67 females) of the Laser class, who participated in a World Cup. Velocity made good (VMG), distance, and maneuvers were evaluated using Global Navigation Satellite System (GNSS) devices in the upwind, downwind, and broad reach courses. VMG in upwind and downwind is the technical variable that determines performance in the Laser class. The VMG is decisive in the performance of elite female sailors in the upwind, downwind, and broad reach courses, while in elite male sailors, performance is mainly influenced by speed in upwind and downwind and the distance covered in upwind. The maneuvers do not determine sailing performance in any of the courses of a regatta.
Influence of Carbon Uniformity on Its Characteristics and Adsorption Capacities of CO2 and CH4 Gases
Authors: Awadallah-F Ahmed , Al-Muhtaseb Shaheen A.
Published: December 2020

Activated carbons of resorcinol-formaldehyde aerogels (AC-RFA) were prepared and mixed with multiwall carbon nanotubes (MWCNTs) with various ratios. Samples were characterized by different techniques. The novelty of the study is in evaluating the effect of uniformity of carbon nanocomposites on their performance for the adsorption of CH4 and CO2 gases as well predicting the separation of their mixtures. The results indicated that, by increasing the percentage of MWCNTs into the sample, its structural uniformity and order ascend. The capacities of CH4 and CO2 by adsorption were measured at various temperatures, and were correlated with the extended dual site Langmuir (DSL) model. Overall, results showed that the adsorption capacity of MWCNTs towards gases is relatively very low compared to that of activated carbons. The DSL model was utilized to forecast the separation of the binary CO2/CH4 mixed gas based on knowledge of single component adsorption isotherm parameters. Adsorption equilibrium data of the CO2/CH4 binary gas mixture was forecasted at different temperatures by DSL model in accordance with the perfect-negative (PN) or perfect-positive (PP) behaviors on the heterogeneous surface of the adsorbent.
Deep-Learning Based Positron Range Correction of PET Images
Authors: Herraiz Joaquín L. , Bembibre Adrián , López-Montes Alejandro
Published: December 2020

Positron emission tomography (PET) is a molecular imaging technique that provides a 3D image of functional processes in the body in vivo. Some of the radionuclides proposed for PET imaging emit high-energy positrons, which travel some distance before they annihilate (positron range), creating significant blurring in the reconstructed images. Their large positron range compromises the achievable spatial resolution of the system, which is more significant when using high-resolution scanners designed for the imaging of small animals. In this work, we trained a deep neural network named Deep-PRC to correct PET images for positron range effects. Deep-PRC was trained with modeled cases using a realistic Monte Carlo simulation tool that considers the positron energy distribution and the materials and tissues it propagates into. Quantification of the reconstructed PET images corrected with Deep-PRC showed that it was able to restore the images by up to 95% without any significant noise increase. The proposed method, which is accessible via Github, can provide an accurate positron range correction in a few seconds for a typical PET acquisition.
Determining Relationships between Marbling Scores and Carcass Yield Traits of German Beef Bull Carcasses Using Video-Image Analysis at the 12th and 10th Rib Position of Longissimus Thoracis and EUROP Classification
Authors: Schulz Lisa , Sundrum Albert
Published: December 2020

In contrast to other international beef classification systems, the European EUROP system disregards marbling in meat quality assessment. Instead, it focuses primarily on the assessment of conformation and fat score. Due to the lack of more specific assessment, beef quality in Germany is less known than beef produced in other countries and is largely incomparable to international standards. The aim of this study was to explore the potential of video-image analysis (VIA) for the assessment of bull carcasses for the commercial beef market in Germany. Marbling scores and carcass traits of 170 carcasses were assessed at the 10th/11th and 12th/13th rib-eye sections of longissimus thoracis. Results showed that VIA is able to precisely assess marbling scores at a German cutting position with a close relation (r = 0.83) to the US position. Furthermore, carcass traits integral to the US Yield Grade, such as rib fat (mean 112 mm) and a modified trait of fat/meat ratio, were assessed at the 10th/11th rib-eye position in a process reliably corresponding to the US position (mean 98 mm). EUROP traits showed only weak relationships with marbling scores, VIA measured rib fat thickness, and carcass weights. Although complete validation of video image analysis requires further research with a higher number of test animals, VIA is a viable tool for classifying the variation of German beef carcasses more reliably during the slaughter line and it could valuably supplement EUROP classification traits.
Estimating Health Impacts Due to the Reduction of Particulate Air Pollution from the Household Sector Expected under Various Scenarios
Authors: Adamkiewicz Łukasz , Kryza Maciej , Mucha Dominika , Werner Małgorzata , Gayer Anna , Drzeniecka-Osiadacz Anetta , Sawiński Tymoteusz
Published: December 2020

Emissions from the household sector are the most significant source of air pollution in Poland, one of the most polluted countries in the EU. Estimated health impacts of the reduction of these emissions under three scenarios are presented. The EMEP4PL model and base year emission inventory were used to estimate average annual PM10 and PM2.5 concentrations with spatial resolution of 4 km × 4 km. The change in emissions under each of the scenarios was based on data from a survey on household boilers and insulation. Scenario 1 included replacement of all poor-quality coal-fired boilers with gas boilers; Scenario 2 included replacement of all poor-quality coal-fired boilers with low-emission boilers but still using solid fuels; and Scenario 3 included the thermal refurbishment of houses with the worst insulation. Impacts on the following health parameters were estimated: premature deaths (PD), Chronic Bronchitis (CB), Bronchitis in Children (BiC) and Work Days Lost (WDL). The concentration–response functions recommended by the WHO HRAPIE project were used. The analysis was conducted for two regions: Lower Silesia and Lodzkie province. The largest reduction of health impact was observed for Scenario 1. For Lower Silesia, the annual PD decreased by 1122 (34.3%), CB by 1516 (26.6%), BiC by 9602 (27.7%) and WDL by 481k (34.7%). For Lodzkie province, the largest impacts were estimated as decreases in PD by 1438 (29.9%), CB by 1502 (25.3%), BiC by 9880 (26.8%) and WDL by 669k (30.4%).
Postoperative Quality of Life after Single-Visit Root Canal Treatment Performed with Reciprocating Shaping Systems: An Observational Study
Authors: Multari Stefania , Alovisi Mario , Berutti Elio , Corbella Stefano , Taschieri Silvio , Carpegna Giorgia , Scotti Nicola , Comba Allegra , Pasqualini Damiano
Published: December 2020

Postoperative pain is a frequent complication of root canal treatment. It could worse patients’ quality of life (QoL) and it may be associated to several factors, including the shaping technique. The aim of the study was to compare the impact of WaveOne Gold (WOG) and WaveOne Classic (WOC) reciprocating instrumentation on postoperative QoL after single-visit primary root canal treatment. Healthy subjects with pulp necrosis on multirooted teeth were observed. Canal shaping was performed with WaveOne Gold Primary (n = 25) or WaveOne Classic Primary (n = 29) and canal filling was completed with a carrier-based technique. Mean and maximum scores for postoperative pain were assessed through a Visual Analogue Scale (VAS) and QoL indicators were evaluated with a self-assessment questionnaire based on a Likert scale. Postoperative pain curves were similar in both groups (mean pain p = 0.43; maximum pain p = 0.27) and quality of life indicators showed no significant differences (p > 0.05). There was a more favourable trend of QoL values in the WOG group, reaching statistical significance on day six posttreatment (p = 0.021). Within the limitations of the study, reciprocating instrumentation may have an impact on patients’ QoL, but the innovative geometrical and alloy properties of the WaveOne Gold seemed to induce a faster resolution of the postoperative symptoms.
Review of Indoor Positioning: Radio Wave Technology
Authors: Kim Geok Tan , Zar Aung Khaing , Sandar Aung Moe , Thu Soe Min , Abdaziz Azlan , Pao Liew Chia , Hossain Ferdous , Tso Chih P. , Yong Wong Hin
Published: December 2020

The indoor positioning system (IPS) is becoming increasing important in accurately determining the locations of objects by the utilization of micro-electro-mechanical-systems (MEMS) involving smartphone sensors, embedded sources, mapping localizations, and wireless communication networks. Generally, a global positioning system (GPS) may not be effective in servicing the reality of a complex indoor environment, due to the limitations of the line-of-sight (LoS) path from the satellite. Different techniques have been used in indoor localization services (ILSs) in order to solve particular issues, such as multipath environments, the energy inefficiency of long-term battery usage, intensive labour and the resources of offline information collection and the estimation of accumulated positioning errors. Moreover, advanced algorithms, machine learning, and valuable algorithms have given rise to effective ways in determining indoor locations. This paper presents a comprehensive review on the positioning algorithms for indoors, based on advances reported in radio wave, infrared, visible light, sound, and magnetic field technologies. The traditional ranging parameters in addition to advanced parameters such as channel state information (CSI), reference signal received power (RSRP), and reference signal received quality (RSRQ) are also presented for distance estimation in localization systems. In summary, the recent advanced algorithms can offer precise positioning behaviour for an unknown environment in indoor locations.
Coupled Convolutional Neural Network-Based Detail Injection Method for Hyperspectral and Multispectral Image Fusion
Authors: Lu Xiaochen , Yang Dezheng , Jia Fengde , Zhao Yifeng
Published: December 2020

In this paper, a detail-injection method based on a coupled convolutional neural network (CNN) is proposed for hyperspectral (HS) and multispectral (MS) image fusion with the goal of enhancing the spatial resolution of HS images. Owing to the excellent performance in spectral fidelity of the detail-injection model and the image spatial–spectral feature exploration ability of CNN, the proposed method utilizes a couple of CNN networks as the feature extraction method and learns details from the HS and MS images individually. By appending an additional convolutional layer, both the extracted features of two images are concatenated to predict the missing details of the anticipated HS image. Experiments on simulated and real HS and MS data show that compared with some state-of-the-art HS and MS image fusion methods, our proposed method achieves better fusion results, provides excellent spectrum preservation ability, and is easy to implement.
Digital Transformation of the Etymological Dictionary of Geographical Names
Authors: Kubik Tomasz
Published: December 2020

This article aims to contribute to the methodology of the structuring of etymological dictionaries of geographical names and the popularization of knowledge regarding the origin of Silesian toponyms. It is based on experiences gathered during the digitization and publication in an electronic form of the SENGŚ (“Etymological Dictionary of Geographical Names of Silesia”) and addresses the problems encountered. The article discusses the rules applied in the compilation of the SENGŚ and presents two information models used during the digitalization of this dictionary: a relational model and a graph model. The first one corresponds to standard approaches when designing electronic versions of dictionaries. The second allows the creation of solutions conforming to the idea of Linked Open Data, which are deployable as parts of the Semantic Internet. An important aspect also considered was the linking of historical materials listed in the dictionary entries with the corresponding records maintained in digital repositories. This association was realized using the AZON platform (“Atlas of Open Scientific Resources”).
Design of a Bubble Reactor for Altitude Simulators Used to Humidify a Combustion Air Stream by Means of CFD Multi-Phase Models
Authors: Serrano José Ramón , Gil Antonio , Quintero Pedro , Tabet Roberto , Gómez Javier
Published: December 2020

In this paper, a procedure for the design of a bubble reactor which allows the control of the humidity of a gas stream used as combustion air is presented. This reactor is designed to be used as a component of an altitude simulator test facility for the optimization, homologation and calibration of new hybrid engines. The design has been carried out by means of Computational Fluid Dynamics (CFD) multi-phase models and validated against the experimental data obtained from the developed prototype. A discussion about the adequate mesh topology and cell size is presented, as well as a comparison between the two available models for the air–water interphase. Lastly, a validation of the CFD results using experimental data shows that the model that should be used is the multi-regime interaction model, from which the final design for the bubble reactor was obtained.
Inverted F Type Antenna Design for the Cattle Activity and Estrus Detection Sensor Module
Authors: Chung Youchung
Published: December 2020

In this paper, an inverted F type antenna (IFA) for ZigBee communication of a sensor board has been designed and optimized, and it replaces the chip antenna on an RF (Radio Frequency) module that is not performing well enough for the ZigBee communication. The sensor board detects cattle behavior and identifies the breeding (estrus) period and transmits the data to the main station by the RF (Radio Frequency) module and IFA antenna. The proposed and optimized TRx (transmitting/receiving) IFA antenna of the ZigBee communication module has a return loss of −19 dB and a gain of 1.6 dB at 2.45 GHz. The size is about 2.5 × 0.5 cm in width and vertical length, and the height is 0.55 cm. The strength of signals with the chip antenna and the IFA antenna have been measured and compared. There is about a 20 dB enhancement with the IFA antenna compared to the chip antenna. The antenna is designed and applied to the RF transmission and reception (TRx) module. This antenna and sensor module can be applied to livestock in general as well as cattle.
Numerical Modeling of Heat and Mass Transfer during Cryopreservation Using Interval Analysis
Authors: Skorupa Anna , Piasecka-Belkhayat Alicja
Published: December 2020

In the paper, the numerical analysis of heat and mass transfer proceeding in an axially symmetrical articular cartilage sample subjected to the cryopreservation process is presented. In particular, a two-dimensional (axially symmetrical) model with imprecisely defined parameters is considered. The base of the heat transfer model is given by the interval Fourier equation and supplemented by initial boundary conditions. The phenomenon of cryoprotectant transport (Me2SO) through the extracellular matrix is described by the interval mass transfer equation. The liquidus-tracking (LT) method is used to control the temperature, which avoids the formation of ice regardless of the cooling and warming rates. In the LT process, the temperature decreases/increases gradually during addition/removal of the cryoprotectant, and the articular cartilage remains on or above the liquidus line so that no ice forms, independent of the cooling/warming rate. The discussed problem is solved using the interval finite difference method with the rules of directed interval arithmetic. Examples of numerical computations are presented in the final part of the paper. The obtained results of the numerical simulation are compared with the experimental results, realized for deterministically defined parameters.
A Theoretical Model with Which to Safely Optimize the Configuration of Hydraulic Suspension of Modular Trailers in Special Road Transport
Authors: Escribano-García Rubén , Corral-Bobadilla Marina , Somovilla-Gómez Fátima , Lostado-Lorza Rubén , Ahmed Ash
Published: December 2020

The dimensions and weight of machines, structures, and components that need to be transported safely by road are growing constantly. One of the safest and most widely used transport systems on the road today due to their versatility and configuration are modular trailers. These trailers have hydraulic pendulum axles that are that are attached in pairs to the rigid platform above. In turn, these modular trailers are subject to limitations on the load that each axle carries, the tipping angle, and the oil pressure of the suspension system in order to guarantee safe transport by road. Optimizing the configuration of these modular trailers accurately and safely is a complex task. Factors to be considered include the load’s characteristics, the trailer’s mechanical properties, and road route conditions including the road’s slope and camber, precipitation and direction, and force of the wind. This paper presents a theoretical model that can be used for the optimal configuration of hydraulic cylinder suspension of special transport by road using modular trailers. It considers the previously mentioned factors and guarantees the safe stability of road transport. The proposed model was validated experimentally by placing a nacelle wind turbine at different points within a modular trailer. The weight of the wind turbine was 42,500 kg and its dimensions were 5133 × 2650 × 2975 mm. Once the proposed model was validated, an optimization algorithm was employed to find the optimal center of gravity for load, number of trailers, number of axles, oil pressures, and hydraulic configuration. The optimization algorithm was based on the iterative and automatic testing of the proposed model for different positions on the trailer and different hydraulic configurations. The optimization algorithm was tested with a cylindrical tank that weighed 108,500 kg and had dimensions of 19,500 × 3200 × 2500 mm. The results showed that the proposed model and optimization algorithm could safely optimize the configuration of the hydraulic suspension of modular trailers in special road transport, increase the accuracy and reliability of the calculation of the load configuration, save time, simplify the calculation process, and be easily implemented.
Synthesis and Antiplasmodial Activity of Novel Bioinspired Imidazolidinedione Derivatives
Authors: Jaromin Anna , Czopek Anna , Parapini Silvia , Basilico Nicoletta , Misiak Ernest , Gubernator Jerzy , Zagórska Agnieszka
Published: December 2020

Malaria is an enormous threat to public health, due to the emergence of Plasmodium falciparum resistance to widely-used antimalarials, such as chloroquine (CQ). Current antimalarial drugs are aromatic heterocyclic derivatives, most often containing a basic component with an added alkyl chain in their chemical structure. While these drugs are effective, they have many side effects. This paper presents the synthesis and preliminary physicochemical characterisation of novel bioinspired imidazolidinedione derivatives, where the imidazolidinedione core was linked via the alkylene chain and the basic piperazine component to the bicyclic system. These compounds were tested against the asexual stages of two strains of P. falciparum—the chloroquine-sensitive (D10) and chloroquine-resistant (W2) strains. In parallel, in vitro cytotoxicity was investigated on a human keratinocyte cell line, as well as their hemolytic activity. The results demonstrated that the antiplasmodial effects were stronger against the W2 strain (IC50 between 2424.15–5648.07 ng/mL (4.98–11.95 µM)), compared to the D10 strain (6202.00–9659.70 ng/mL (12.75–19.85 µM)). These molecules were also non-hemolytic to human erythrocytes at a concentration active towards the parasite, but with low toxicity to mammalian cell line. The synthetized derivatives, possessing enhanced antimalarial activity against the CQ-resistant strain of P. falciparum, appear to be interesting antimalarial drug candidates.
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR
Authors: Chiang An-Jen , Li Chia-Jung , Tsui Kuan-Hao , Chang Chung , Chang Yuan-chin Ivan , Chen Li-Wen , Chang Tsung-Hsien , Sheu Jim Jinn-Chyuan
Published: December 2020

Cervical cancer is a common gynecological malignancy, accounting for 10% of all gynecological cancers. Recently, targeted therapy for cervical cancer has shown unprecedented advantages. Several studies have shown that ubiquitin conjugating enzyme E2 (UBE2C) is highly expressed in a series of tumors, and participates in the progression of these tumors. However, the possible impact of UBE2C on the progression of cervical squamous cell carcinoma (CESC) remains unclear. Here, we carried out tissue microarray analysis of paraffin-embedded tissues from 294 cervical cancer patients with FIGO/TNM cancer staging records. The results indicated that UBE2C was highly expressed in human CESC tissues and its expression was related to the clinical characteristics of CESC patients. Overexpression and knockdown of UBE2C enhanced and reduced cervical cancer cell proliferation, respectively, in vitro. Furthermore, in vivo experiments showed that UBE2C regulated the expression and activity of the mTOR/PI3K/AKT pathway. In summary, we confirmed that UBE2C is involved in the process of CESC and that UBE2C may represent a molecular target for CESC treatment.
AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner
Authors: Bretaudeau Clara , Baud Stéphanie , Dupont-Deshorgue Aurélie , Cousin Rémi , Brassart Bertrand , Brassart-Pasco Sylvie
Published: December 2020

Oral tongue squamous cell carcinoma is one of the most prevalent head and neck cancers. During tumor progression, elastin fragments are released in the tumor microenvironment. Among them, we previously identified a nonapeptide, AG-9, that stimulates melanoma progression in vivo in a mouse melanoma model. In the present paper, we studied AG-9 effect on tongue squamous cell carcinoma invasive properties. We demonstrated that AG-9 stimulates cell invasion in vitro in a modified Boyen chamber model. It increases MMP-2 secretion, analyzed by zymography and MT1-MMP expression, studied by Western blot. The stimulatory effect was mediated through Ribosomal Protein SA (RPSA) receptor binding as demonstrated by SiRNA experiments. The green tea-derived polyphenol, (−)-epigallocatechin-3-gallate (EGCG), was previously shown to bind RPSA. Molecular docking experiments were performed to compare the preferred areas of interaction of AG-9 and EGCG with RPSA and suggested overlapping areas. This was confirmed by competition assays. EGCG abolished AG-9-induced invasion, MMP-2 secretion, and MT1-MMP expression.