bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular adaptation of telomere associated genes in mammals
Authors: Morgan Claire C , Mc Cartney Ann M , Donoghue Mark TA , Loughran Noeleen B , Spillane Charles , Teeling Emma C , O’Connell Mary J
Published: November 2013

Background

Placental mammals display a huge range of life history traits, including size, longevity, metabolic rate and germ line generation time. Although a number of general trends have been proposed between these traits, there are exceptions that warrant further investigation. Species such as naked mole rat, human and certain bat species all exhibit extreme longevity with respect to body size. It has long been established that telomeres and telomere maintenance have a clear role in ageing but it has not yet been established whether there is evidence for adaptation in telomere maintenance proteins that could account for increased longevity in these species.

Results

Here we carry out a molecular investigation of selective pressure variation, specifically focusing on telomere associated genes across placental mammals. In general we observe a large number of instances of positive selection acting on telomere genes. Although these signatures of selection overall are not significantly correlated with either longevity or body size we do identify positive selection in the microbat speciesMyotis lucifugusin functionally important regions of the telomere maintenance genesDKC1andTERT, and in naked mole rat in the DNA repair geneBRCA1.

Conclusion

These results demonstrate the multifarious selective pressures acting across the mammal phylogeny driving lineage-specific adaptations of telomere associated genes. Our results show that regardless of the longevity of a species, these proteins have evolved under positive selection thereby removing increased longevity as the single selective force driving this rapid rate of evolution. However, evidence of molecular adaptations specific to naked mole rat andMyotis lucifugushighlight functionally significant regions in genes that may alter the way in which telomeres are regulated and maintained in these longer-lived species.
Cross-over study of influence of oral vitamin C supplementation on inflammatory status in maintenance hemodialysis patients
Authors: Zhang KunYing , Li YinHui , Cheng XuYang , Liu Li , Bai WenYing , Guo WeiYa , Wu LeiYun , Zuo Li
Published: November 2013

Background

Both vitamin C deficiency and inflammation are prevalent in maintenance hemodialysis (MHD) patients. In this study, we aimed to elucidate the effect of oral vitamin C supplementation on inflammatory status in MHD patients with low vitamin C level and high hypersensitive C-reactive protein (hs-CRP) level.

Methods

A total of 128 patients were recruited in our present study. Patients were divided into two groups. In group 1 (n = 67), patients were orally administered with 200 mg/day vitamin C in the first 3 months, and then the vitamin C supplementation was withdrawn in the next 3 months. In group 2 (n = 61), patients were not given vitamin C in the first 3 months, and then they were orally administered with 200 mg/day in the next 3 months. Levels of hs-CRP, prealbumin, albumin and hemoglobin as well as the EPO resistance index (ERI) were determined at the baseline and every 3 months throughout the study. Plasma vitamin C level was determined by high-performance liquid chromatography with UV detection.

Results

Among the 128 patients, 28 of them dropped out of the study before completion. Consequently, a total of 100 patients (group 1: n = 48; group 2: n = 52) were included in the final analysis. At the baseline, the plasma vitamin C level of all patients was less than 4 μg/mL. However, this proportion was decreased to 20% after the vitamin C supplementation for 3 months. Compared with patients without the vitamin C supplementation, a decreased level of hs-CRP and an increased level of prealbumin were induced by the vitamin C supplementation for 3 months in both groups. However, levels of these biomarkers returned to their original state after the supplementation was withdrawn. Same beneficial effects on plasma albumin, hemoglobin and ERI response to vitamin C supplementation were observed in the two groups without statistical significance.

Conclusions

The inflammatory status in MHD patients with plasma vitamin C deficiency and high levels of inflammatory markers could be partially improved by long-term oral administration of small doses of vitamin C.

Trial registration

The clinical trial number: NCT01356433.
Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine
Authors: Becker Judith , Schäfer Rudolf , Kohlstedt Michael , Harder Björn J , Borchert Nicole S , Stöveken Nadine , Bremer Erhard , Wittmann Christoph
Published: November 2013

Background

The stabilizing and function-preserving effects of ectoines have attracted considerable biotechnological interest up to industrial scale processes for their production. These rely on the release of ectoines from high-salinity-cultivated microbial producer cells upon an osmotic down-shock in rather complex processor configurations. There is growing interest in uncoupling the production of ectoines from the typical conditions required for their synthesis, and instead design strains that naturally release ectoines into the medium without the need for osmotic changes, since the use of high-salinity media in the fermentation process imposes notable constraints on the costs, design, and durability of fermenter systems.

Results

Here, we used aCorynebacterium glutamicumstrain as a cellular chassis to establish a microbial cell factory for the biotechnological production of ectoines. The implementation of a mutant aspartokinase enzyme ensured efficient supply of L-aspartate-beta-semialdehyde, the precursor for ectoine biosynthesis. We further engineered the genome of the basicC. glutamicumstrain by integrating a codon-optimized syntheticectABCDgene cluster under expressional control of the strong and constitutiveC. glutamicum tufpromoter. The resulting recombinant strain produced ectoine and excreted it into the medium; however, lysine was still found as a by-product. Subsequent inactivation of the L-lysine exporter prevented the undesired excretion of lysine while ectoine was still exported. Using the streamlined cell factory, a fed-batch process was established that allowed the production of ectoine with an overall productivity of 6.7 g L-1day-1under growth conditions that did not rely on the use of high-salinity media.

Conclusions

The present study describes the construction of a stable microbial cell factory for recombinant production of ectoine. We successfully applied metabolic engineering strategies to optimize its synthetic production in the industrial workhorseC. glutamicumand thereby paved the way for further improvements in ectoine yield and biotechnological process optimization.
Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms
Authors: Van Nuffel Anouk , Ariën Kevin K , Stove Veronique , Schindler Michael , O’Neill Eduardo , Schmökel Jan , Van de Walle Inge , Naessens Evelien , Vanderstraeten Hanne , Van Landeghem Kathleen , Taghon Tom , Pulkkinen Kati , Saksela Kalle , Garcia J Victor , Fackler Oliver T , Kirchhoff Frank , Verhasselt Bruno
Published: November 2013

Background

A nef gene is present in all primate lentiviral genomes and is important for high viral loads and progression to AIDS in human or experimental macaque hosts of HIV or SIV, respectively. In these hosts, infection of the thymus results in a decreased output of naive T cells that may contribute to the development of immunodeficiency. We have previously shown that HIV-1 subtype B Nef proteins can block human T-cell development. However, the underlying mechanism(s) and the conservation of this Nef function between different groups of HIV and SIV remained to be determined.

Results

We investigated whether reduction of thymic output is a conserved function of highly divergent lentiviral Nef proteins including those from both types of human immunodeficiency viruses (HIV-1 and HIV-2), their direct simian counterparts (SIVcpz, SIVgor and SIVsmm, respectively), and some additional SIV strains. We found that expression of most of these nef alleles in thymocyte progenitors impaired T-cell development and reduced thymic output. For HIV-1 Nef, binding to active p21 protein (Cdc42/Rac)-activated kinase (PAK2) was a major determinant of this function. In contrast, selective disruption of PAK2 binding did not eliminate the effect on T-cell development of SIVmac239 Nef, as was shown by expressing mutants in a newly discovered PAK2 activating structural motif (PASM) constituted by residues I117, H121, T218 and Y221, as well as previously described mutants. Rather, down-modulation of cell surface CD3 was sufficient for reduced thymic output by SIVmac Nef, while other functions of SIV Nefs contributed.

Conclusions

Our results indicate that primate lentiviral Nef proteins impair development of thymocyte precursors into T cells in multiple ways. The interaction of HIV-1 Nef with active PAK2 by HIV-1 seem to be most detrimental, and downregulation of CD3 by HIV-2 and most SIV Nef proteins sufficient for reduced thymic output. Since the reduction of thymic output by Nef is a conserved property of divergent lentiviruses, it is likely to be relevant for peripheral T-cell depletion in poorly adapted primate lentiviral infections.
An investigation of economic costs of schizophrenia in two areas of China
Authors: Zhai Jinguo , Guo Xiaofeng , Chen Min , Zhao Jingping , Su Zhonghua
Published: November 2013

Background

Schizophrenia is a severe psychotic disorder characterized by significant disturbances in thinking, perception, emotions and behavior. Even if it is not a very frequent disorder, but it is the most burdensome and costly illnesses worldwide. The total population was approximate 1.3 billion and there are approximate 8 million schizophrenic patients in China. Despite the wide-ranging financial and social burdens associated with schizophrenia, but there have been few cost-of-illness studies of this illness in China.

Objective

To evaluate the economic cost of schizophrenic patients in China.

Methodology

356 schizophrenic patients who met with DSM-IV criteria were enrolled and investigated with the Economic Burden Questionnaire(EBQ), 299 schizophrenic patients completed the study for 12 months. All the data were combined and classified by researcher. EBQ include all kinds of cost such as direct cost, indirect cost and total cost as well. It was filled in by patients and their close caregivers. Comparison of cost was made between not only out-patients and in-patients but also urban patients and rural patients. Multiple stepwise regression analysis was made to identify the main influence factors of total cost.

Results

(i) The per case per annum total costs, direct costs and indirect costs of schizophrenia amounted to US$2586.21, US$862.81(33.4%) and US$1723.40(66.6%) respectively. The per case total cost, direct cost and direct medical cost of in-patients were more higher than out-patients (P < 0.05). (ii) There was significant difference in per case per annum total cost, direct cost, direct medical cost, cost due to lost working-days and disability between urban and rural schizophrenic patients (P < 0.05), the former is higher than the latter. (iii) The results of multivariate stepwise regression analysis show that five variables were significantly correlated with higher cost: professional status(cadre), diagnostic subtype(residual schizophrenia), urban or rural patients(urban patients), in-patients or out-patients(in-patients) and researcher centre(southern center). The standardized regression coefficient were 0.308, 0.218, 0.212, 0.156 and 0.149 respectively, the correlation of determination R square was 0.2741, F = 15.651, P < 0.0000. These characteristics explain 27.41% of the variability in the total cost.

Conclusion

(i) Economic cost of schizophrenia were serious, we must pay close attention to it. (ii) The indirect cost are the majority of the total cost. The cost of urban patients are more higher than the cost of rural patients, the cost of in-patients are more higher than the cost of out-patients.
Structural updates of alignment of protein domains and consequences on evolutionary models of domain superfamilies
Authors: Mutt Eshita , Rani Sudha Sane , Sowdhamini Ramanathan
Published: November 2013

Background

Influx of newly determined crystal structures into primary structural databases is increasing at a rapid pace. This leads to updation of primary and their dependent secondary databases which makes large scale analysis of structures even more challenging. Hence, it becomes essential to compare and appreciate replacement of data and inclusion of new data that is critical between two updates. PASS2 is a database that retains structure-based sequence alignments of protein domain superfamilies and relies on SCOP database for its hierarchy and definition of superfamily members. Since, accurate alignments of distantly related proteins are useful evolutionary models for depicting variations within protein superfamilies, this study aims to trace the changes in data in between PASS2 updates.

Results

In this study, differences in superfamily compositions, family constituents and length variations between different versions of PASS2 have been tracked. Studying length variations in protein domains, which have been introduced by indels (insertions/deletions), are important because theses indels act as evolutionary signatures in introducing variations in substrate specificity, domain interactions and sometimes even regulating protein stability. With this objective of classifying the nature and source of variations in the superfamilies during transitions (between the different versions of PASS2), increasing length-rigidity of the superfamilies in the recent version is observed. In order to study such length-variant superfamilies in detail, an improved classification approach is also presented, which divides the superfamilies into distinct groups based on their extent of length variation.

Conclusions

An objective study in terms of transition between the database updates, detailed investigation of the new/old members and examination of their structural alignments is non-trivial and will help researchers in designing experiments on specific superfamilies, in various modelling studies, in linking representative superfamily members to rapidly expanding sequence space and in evaluating the effects of length variations of new members in drug target proteins. The improved objective classification scheme developed here would be useful in future for automatic analysis of length variation in cases of updates of databases or even within different secondary databases.
Σημείωμα για τα σαραντάχρονα τοy Ερανιστή, ή o ΟΜΕΔ, το ΚΝΕ και O Ερανιστής
Authors: Αποστολόπουλος Δημήτρης Γ.
Published: November 2013

no abstract
Πρωτοσέλιδα
Authors: Eranistes Eranistes
Published: November 2013

no abstract
Περιεχόμενα του εικοστού πέμπτου τόμου
Authors: Eranistes Eranistes
Published: November 2013

no abstract
The exploitation of otherness in the economic advancement of the Rum millet
Authors: Balta Evangelia
Published: November 2013

no abstract
Σωφρόνιος ο Συρόπουλος. Τα χρονικά όρια της θητείας του τρίτου μετά την Άλωση πατριάρχη κατά τη μαρτυρία του Θεόδωρου Αγαλλιανού
Authors: Αποστολόπουλος Δημήτρης Γ.
Published: November 2013

SÔPHRONIOS SYROPOULOS
Les dates limites du sacerdoce du troisième patriarche après la chute de Constantinople selon le témoignage de Theodoros Agallianos

Theodoros Agallianos, premier grand chartophylax du Patriarcat de Constantinople après la prise de la Ville par les Ottomans, a noté de sa main dans un manuscrit juridique que : (a) le troisième patriarche après la chute de Constantinople fut Sôphronios Syropoulos ; (b) il occupa le trône patriarcal pendant un an et demi ; c) son sacerdoce se termina par une révocation : «il fut chassé», note-t-il.
 Le présent travail explique d’abord la manière dont le texte d’Agallianos nous est parvenu et en examine la validité ; puis il évalue les informations qu’il contient concernant l’ordre des premiers patriarches après la chute de Constantinople et la durée du patriarcat de Sôphronios. Selon les dires d’Agallianos, il dut prendre fin à l’automne 1463. Par conséquent, un document patriarcal portant le nom de Sôphronios et prétendument émis en août 1464, non content d’être un faux quant à son contenu, comme on l’a déjà soutenu, porte en outre une date qui ne correspond pas au laps de temps où Sôphronios fut patriarche.

DIMITRIS G. APOSTOLOPOULOS
Στην Πάτμο το δέκατο έκτο αιώνα. Ο καραβοκύρης κι επιχειρηματίας Διάκος της Κρητικής
Authors: Ζαχαριάδου Ελισάβετ Α.
Published: November 2013

ΙΝ PATMOS IN THE 16th CENTURY
Diakos, Son of Kritikis, Ship-owner and Businessman

It is well-established that the island of Patmos was prosperous and thriving by the end of the 16th century. This article examines the case of a successful ship-owner and entrepreneur from Patmos, who can be considered as a representative of this period: with his business connected to the sea, his relations with the Ottoman authorities, his wealth and his attachment to the Greek-Orthodox faith. Although he became somehow an almost legendary figure, his will, preserved in the archive of the Monastery of Patmos, reveals his approach to thought and action.

ELISABETH A. ZACHARIADOU
Αυτοβιογραφικός λόγος και περιπλάνηση στις απαρχές του νεοελληνικού μυθιστορήματος
Authors: Πολυκανδριώτη Ράνια
Published: November 2013

no abstract
Ιωάννινα ή Μυτιλήνη; Νέα στοιχεία για την πρώτη γνωστή απόπειρα παρέμβασης στην προικοδοτική διαδικασία (αρχές 18ου αι.)
Authors: Μιχαηλάρης Παναγιώτης Δ.
Published: November 2013

IOANNINA OR MYTILENE
New Data on the First-known Attempt of Intervention
in the Dowry Process (Early 18th Century)

This article, based on a patriarchal act contained in Codex A of the Metropolis of Mytilene, by the Patriarch Gabriel III (on 5 May 1705) and published recently (2006), corrects an error of Manouil Gedeon. The renowned scholar found the same letter in the codex Critias A and published it in Kanonikes Diataxeis. Gedeon attributed the letter to the Patriarch Kallinikos II and dated it to the early 18th century, although in the codex Critias A, which we have seen recently, the letter in question does not bear either the patriarch’s name nor a date, evidence which we know now thanks to the copy of Codex A of Mytilene. Furthermore, this article proves that the place where the first-known attempt to regulate the dowry process took place was the Metropolis of Mytilene, not Ioannina, as Gedeon claimed.

PANAGIOTIS D. MICHAILARIS
Τα «Βασιλικά Ινστιτούτα» (1706). Ένα αθησαύριστο έργο του Νικολάου Κομνηνού Παπαδοπούλου και η διάδοσή του στον ελληνικό χώρο
Authors: Τάνταλος Μάριος Θ.
Published: November 2013

THE «ROYAL INSTITUTES» (1706)
An Unknown Work of Nikolaos Komnenos Papadopoulos
and its Diffusion

Three 18th-century manuscripts – Patmiacus gr. 361, Metochion [monastery dependency] of the Holy Sepulchre of Constantinople 449 and Greek Philological Society of Constantinople [Türk Tarih Kurumu] 59 – undoubtedly contain the same unpublished text, namely the «Royal Institutes». The «Royal Institutes» is a didactical explanation in Greek of the Justinian «Institutes». In this paper, we propose that its author was Nikolaos Komnenos Papadopoulos, a Cretan professor at the law school of Padua. We also argue that Papadopoulos completed the «Royal Institutes» in the spring of 1706, as requested by his former student and later the Patriarch of Jerusalem, Chrysanthos Notaras. Chrysanthos, in turn, used the «Royal Institutes» as a source for his own compendium, the «Introduction to the Laws».

MARIOS TANTALOS
Ιστορίες πρόσληψης έργων της Κρητικής Αναγέννησης. Ο Byron και η Βοσκοπούλα: Η διαιώνιση μιας παρεξήγησης
Authors: Κατσιγιάννης Αλέξανδρος
Published: November 2013

BYRON AND THE RECEPTION
OF THE CRETAN PASTORAL POEM VOSKOPOULA
The Prolonging of a Misunderstanding

In this essay I will discuss whether Byron was indeed influenced by the Cretan pastoral poem Voskopoula in some cantos of his epic-satiric poem Don Juan (published in 1819), as argued by D.C. Hesseling in 1938 and by several researchers after him. This discussion stands as a starting point to analysing the reception of the literary works of the Cretan Renaissance by English scholars in the first two decades of the 19th century. In parallel, I hope that this article will shed light upon the troubling matter of the popular reception of Cretan Renaissance poetry and demotic songs by the scholars of the Enlightenment and Romanticism, which led to several misunderstandings concerning the character, origin and dissemination of Cretan Renaissance poetry in the scholars’ discourse network throughout the 19th century.

ALEXANDER KATSIGIANNIS
Από τον Κωνσταντίνο Οικονόμο στον Παύλο Καλλιγά. «Ένα μάθημα κανονικού δικαίου» χωρίς αποδέκτες
Authors: Πιτσάκης Κωνσταντίνος Γ.
Published: November 2013

DE CONSTANTIN OIKONOMOS A PAUL CALLIGAS :
« Une leçon de droit canonique » que l’on n’a pas apprise

Une correspondance de 1825 entre le canoniste russe Gustav Andreevič Rozenkampf (1764-1832) et Constantin Oikonomos (1780-1857), mise en évidence en 2008 par Igor P. Medvedev d’après les papiers de Rozenkampf dans les archives de Saint-Pétersbourg, est ici complétée par des documents conservés dans les archives Oikonomos au Centre de Recherche sur l’Hellénisme Médiéval et Moderne de l’Académie d’Athènes et fournie d’un commentaire. Rozenkampf s’intéresse surtout au Pédalion du 1800 qu’il regarde, à tort, comme une édition moderne d’une vieille collection canonique grecque, dont le patriarcat de Constantinople aurait fait son code officiel ; cette prétendue ancienne version du Pédalion aurait été le modèle ou la source principale de la Kormčaja Kniga russe. Oikonomos répond d’une manière quelque peu superficielle aux questions de Rozenkampf, dont il ne saisit sans doute pas le contexte, mais il rend clair le caractère non-officiel du Pédalion, en tant qu’une simple édition privée moderne et commentée des canons. Rozenkampf ne semble pas avoir tiré profit de ces réponses. Mais on peut maintenant en établir un emploi passé inaperçu : une partie des réponses d’Oikonomos, envoyée par Rozenkampf à Friedrich August Biener (1787-1861), a été citée dans son De collectionibus canonum ecclesiae graecae schediasma litterarium (Berlin 1827), traduit par la suite en grec par Paul Calligas (1814-1896) en 1840 : même ici, les réponses d’Oikonomos ont été employées en dehors voire à l’encontre de leur contexte.
C. G. PITSAKIS
Ανιχνεύοντας νέα ευρήματα της κοραϊκής αλληλογραφίας
Authors: Φασουλάκης Στέριος
Published: November 2013

no abstract
Le Glaneur : Table des matieres
Authors: Eranistes Eranistes
Published: November 2013

no abstract
Περιεχόμενα
Authors: Eranistes Eranistes
Published: November 2013

No abstract
Ανέκδοτα χειρόγραφα του ιερέα Παναγή/Μαρίνου Φωκά. (Επιτομή Γραμματικής 1810, Επιτομή Λογικής 1811, Τί εστιν Άνθρωπος 1811)
Authors: Αλισανδράτος Γιώργος Γ.
Published: November 2013

No abstract
Η βιβλιοθήκη του Κ. Μηνά Μηνωίδη στις Σέρρες (1815-1819) και η τύχη της
Authors: Κουτζακιώτης Γιώργος
Published: November 2013

No abstract
Μ. Χουρμούζης. Βιογραφικές συμπληρώσεις
Authors: Σφυρόερας Βασ. Βλ.
Published: November 2013

No abstract
Βιβλιογραφικά σημειώματα
Authors: Πατρινέλης Χ. Γ.
Published: November 2013

no abstract
Σύμμικτα περί Αθανασίου Ψαλίδα με βάση το Αρχείο του
Authors: Πέτσιος Κώστας Θ.
Published: November 2013

no abstract
“Χριστιανική απολογία” (1798) και “Απολογία χριστιανική” (1800, 1805)
Authors: Αποστολόπουλος Δ. Γ.
Published: November 2013

no abstract
Η ανέκδοτη πραγματεία Περί αστρολάβου του Θεοφίλου Κορυδαλλέως
Authors: Τσιότρας Βασίλειος Ι.
Published: November 2013

No abstract
Τέσσερις αθησαύριστες μεταφράσεις πεζών ποιημάτων του Salomon Gessner (1820)
Authors: Πολίτης Αλέξης
Published: November 2013

no abstract
Το πρωτότυπο του «Περί της των συμβουλιών ματαιότητος»
Authors: Αποστολόπουλος Δ. Γ.
Published: November 2013

No abstract
Βιβλιολογικά παρασχολήματα
Authors: Ηλιού Φίλιππος
Published: November 2013

No abstract
Άγνωστο ή ανύπαρκτο επώνυμο του Νικοδήμου του Αγιορείτη;
Authors: Πιτσάκης Κ. Γ.
Published: November 2013

No abstract
Λέανδρος Βρανούσης, 1921-1993: Οι δύο ιστορίες
Authors: Ασδραχάς Σπ. Ι.
Published: November 2013

No abstract
Συλλογή φαναριώτικων στιχουργημάτων σε κώδικα των μέσων του ΙΗ΄ αιώνα
Authors: Σοφιανός Δημήτρης Ζ.
Published: November 2013

No abstract
Η δυναμική του Διαφωτισμού στη δράση των Κολλυβάδων
Authors: Μεταλληνός π. Γεώργιος Δ.
Published: November 2013

No abstract
Απόψεις και παρεμβάσεις του Κοραή στο θέμα των μεταφράσεων
Authors: Πάτσιου Βίκυ
Published: November 2013

No abstract
Οι αντιλήψεις των ξένων για τον Νεοελληνικό Διαφωτισμό
Authors: Αγγελομάτη–Τσουγκαράκη Ελένη
Published: November 2013

No abstract
Η μετάβαση στη σοφή Ευρώπη και οι συνέπειές της. Ο αρχιμανδρίτης Γρηγόριος Καλαγάνης
Authors: Στασινοπούλου Μαρία Α.
Published: November 2013

No abstract
«Κυκεών». Ένας γιαννιώτικος κώδικας του 19ου αιώνα και ο Λέανδρος Βρανούσης
Authors: Κουρμαντζή Ελένη
Published: November 2013

No abstract
Απόπειρες ελληνικών μεταφράσεων του μυθιστορήματος του Thomas Hope Anastasius
Authors: Αγγελομάτη–Τσουγκαράκη Ελένη
Published: November 2013

No abstract
Οι πρώτοι δάσκαλοι της Σχολής Κοζάνης (Από τον Γεώργιο Κονταρή ώς τον Ευγένιο Βούλγαρη)
Authors: Πατρινέλης Χ. Γ.
Published: November 2013

No abstract
L.-P. Jussieu, Simon de Nantua (1818). Η περιπλάνηση του αγαθού εμπόρου και οι αφηγηματικές της προσαρμογές στα ελληνικά
Authors: Πάτσιου Βίκυ
Published: November 2013

No abstract
L’Aufklärung néo-hellénique. La question sociale et ses issues politiques
Authors: Apostolopoulos Dimitris G.
Published: November 2013

No abstract
Οι αναβαθμοί της απομνημόνευσης και οι πολιτικές στρατηγικές μιας οικογένειας
Authors: Λιάτα Ευτυχία Δ.
Published: November 2013

No abstract
Η δυσμένεια του Αθανάσιου Πάριου προς τον Δωρόθεο Πρώϊο
Authors: Μακρίδης Βασίλειος Ν.
Published: November 2013

No abstract
Μια θεατρική παράσταση στην Κωνσταντινούπολη το 1821. Η μαρτυρία του R. Walsh
Authors: Ταμπάκη Άννα
Published: November 2013

No abstract
Τα «ελληνικά βιβλία» και οι Ρώσοι «παλαιόπιστοι» στα μέσα του 17ου αιώνα
Authors: Αλεξανδροπούλου Όλγα
Published: November 2013

no abstract
Για μια ορατή αρχαιότητα. Μεθοδολογία, χρήσεις και λειτουργίες του χάρτη της Ελλάδας του Νικόλαου Σοφιανου
Authors: Τόλιας Γιώργος
Published: November 2013

no abstract
Φυσική δημώδης εις παύσιν της δεισιδαιμονίας, Βιέννη 1810. Ποιος ο συγγραφέας και ο μεταφραστής του βιβλίου;
Authors: Καραμπερόπουλος Δημήτριος Απ.
Published: November 2013

no abstract
Η Πατριαρχική Τυπογραφία της Κωνσταντινούπολης και ο τεχνικός εξοπλισμός της στα 1820
Authors: Λάππας Κώστας
Published: November 2013

no abstract
Με σεβασμό και ασέβεια. Ο Φίλιππος Ηλιού αναγνώστης και εργογράφος του Κ. Θ. Δημαρά
Authors: Πολέμη Πόπη
Published: November 2013

no abstract
Ένα εγχειρίδιο αρχαιοελληνικής μετρικής του 17ου αιώνα
Authors: Τσιότρας Βασίλης
Published: November 2013

no abstract
Βιβλιόφιλοι και «κυνηγοί» χειρογράφων στη Θεσσαλονίκη τον 18ο αιώνα. Ο κόσμος του βιβλίου μέσα από τις επιστολές ενός Ιησουίτη
Authors: Κουτζακιώτης Γιώργος
Published: November 2013

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Προσπάθειες για προεγγραφή συνδρομητών
Authors: Λαγανάς Γεώργιος
Published: November 2013

no abstract
Η ηλικία και τα οικογενειακά του Δ. Βυζάντιου σε μία απογραφή πληθυσμού του Ναυπλίου το 1835
Authors: Φραγκίσκος Εμμ. Ν.
Published: November 2013

no abstract
L’exaporrite Alexandre Mavrocordatos (αραβική γραφή)
Authors: Bouchard Jacques
Published: November 2013

no abstract
Προσθήκες στην ελληνική βιβλιογραφία. Νέα στοιχεία για τα δύο έντυπα έργα του πατριάρχη Καλλινίκου Γ'
Authors: Τσακίρης Βασίλειος
Published: November 2013

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The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells
Authors: Hartmann Michael , Hemmerlin Andrea , Gas-Pascual Elisabet , Gerber Esther , Tritsch Denis , Rohmer Michel , Bach Thomas J
Published: November 2013

We have established anin vivovisualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, based on the expression of a dexamethasone-inducible GFP fused to the carboxy-terminal basic domain of the rice calmodulin CaM61, which naturally bears a CaaL geranylgeranylation motif (GFP-BD-CVIL). By using pathway-specific inhibitors it was demonstrated that inhibition of the methylerythritol phosphate (MEP) pathway with known inhibitors like oxoclomazone and fosmidomycin, as well as inhibition of the protein geranylgeranyltransferase type 1 (PGGT-1), shifted the localization of the GFP-BD-CVIL protein from the membrane to the nucleus. In contrast, the inhibition of the mevalonate (MVA) pathway with mevinolin did not affect the localization. During the present work, this test system has been used to examine the effect of newly designed inhibitors of the MEP pathway and inhibitors of sterol biosynthesis such as squalestatin, terbinafine and Ro48-8071. In addition, we also studied the impact of different post-prenylation inhibitors or those suspected to affect the transport of proteins to the plasma membrane on the localization of the geranylgeranylable fusion protein GFP-BD-CVIL.
Perspective éco-critique: La nature dans trois romans de Roumain, Zobel et Condé
Authors: Rehill Annie
Published: November 2013

In postcolonial Caribbean literature, a tendency to mimic the European Edenic paradigm (to disrupt it) has often been noted. But there is another aspect that is useful from an eco-critical perspective: human life is frequently portrayed in a less anthropocentric way than in its European counterpart. Antillean authors show evidence of a deeper understanding that humans are only one of the life forms that earth supports. Three novels analysed in this article – Roumain’s Gouverneurs de la rosée, Zobel’s La rue cases-nègres and Condé’s Traversée de la mangrove – illustrate a predisposition to perceive nature in a way that appears closer to Amerindian and African ideas than to those originating from European culture, insofar as the ability to live with, not only to exploit, nature. This represents a state of mind that is essential in helping to change the approach of modern enterprises towards planet Earth.

Dans les écrits postcoloniaux des Antilles, on a souvent remarqué une tendance à mimer (pour le perturber) le paradigme édénique européen. Mais il y a un autre aspect qui est utile aux efforts éco-critiques: la vie humaine est considérée d’une manière souvent moins anthropocentrique que dans la littérature européenne. De ce point de vu, il est clair que les auteurs antillais comprennent plus profondément que la vie humaine n’est qu’une des formes de vie que soutient la terre. Trois romans analysés dans cet article – Gouverneurs de la rosée de Roumain, La rue cases-nègres de Zobel et Traversée de la mangrove de Condé – illustrent une prédisposition à comprendre la nature d’une façon plus proche des idées amérindiennes et africaines que celles qui proviennent de l’Europe, en tant que la capacité de vivre avec, pas seulement d’exploiter, la nature. Ceci représente un état d’esprit qui est essentiel dans les efforts contemporains vers un changement des paradigmes de l’entreprise moderne en ce qui concerne la terre.
The passion for origins in the epic poems of Édouard Glissant
Authors: Poiana Peter
Published: November 2013

Entre l’idée, avancée par Lorna Burns, selon laquelle la créolisation est essentiellement un processus positif de devenir-antillais, et l’insistance, chez John Drabinski, sur l’expérience traumatisante qui le précède historiquement et ontologiquement, s’ouvre un espace où la poésie de Glissant s’affirme comme un mode de constitution de la conscience antillaise. Car la poésie, bien plus que les essais et les romans qui occupent la part belle de la littérature antillaise, dévoile le cadre affectif où l’histoire improbable d’une survie peut se déployer pleinement. En effet, la poésie de Glissant crée les conditions discursives sous lesquelles la souffrance des premières sociétés esclavagistes, loin de se dialectiser ou de se hypostasier, se révèle dans sa nécessité paradoxale. L’obsession du poète qui s’obstine à reprendre le cri primitif est largement admise. Chez Glissant, elle apparaît sous la guise d’une folie ou d’une passion de l’origine, terme que nous empruntons à Jacques Derrida en nous inspirant de son traitement de la notion de trace. Cette étude tente d’approfondir ces questions en examinant de près trois poèmes épiques de Glissant: Le Sel noir, Les Indes et Pays rêvé, pays réel, en relevant notamment trois motifs qui leur sont communs: le poème comme séparation, le poème comme trace, et le poème comme souffrance./ Between Lorna Burns’s description of Glissant’s creolization as a positive process of ‘becoming-Caribbean’ and John Drabinski’s foregrounding of the trauma that precedes it historically and ontologically, a space opens up in which Glissant’s poetry establishes itself as a mode of construction of Caribbean consciousness. For poetry, more than the essays and novels that proliferate in Caribbean literature, lays bare the emotional framework of the implausible story of survival. Indeed, Glissant’s poetry creates the discursive conditions in which the suffering of the first slave communities is not dialecticized or hypostasized, but made to reveal itself in its paradoxical necessity. The poet’s obsession to repeat the original cry is a familiar one. In Glissant’s poetry, it takes the form of a folly or passion for origins, understood here in terms of Jacques Derrida’s treatment of the notion of the trace. This study attempts to further our understanding of this passion by examining three epic poems by Glissant, Le Sel noir, Les Indes and Pays rêvé, pays réel, focusing in particular on three common motifs: the poem as separation, the poem as trace, and the poem as suffering.
Sonic mobilizations from the margins of the Caribbean colonial text
Authors: O’Dell Gretchen
Published: November 2013

During colonial times, especially during the time period surrounding the abolition of slavery and World War II, rumours and other oral discursive strategies dominated in Guadeloupe and Martinique, in spite of colonial attempts to fix both the identity of colonized subjects and the meaning of contemporary events. This article will use Judith Butler’s essentially deconstructive notion of censorship to examine discursive strategies practiced by the French colonizers and the Franco-Caribbean colonized to illustrate interdependence and co-creation of meaning in this context of uncertainty and desire for access to information.

Pendant l’époque coloniale, en particulier pendant l’abolition de l’esclavage et la deuxième guerre mondiale, les rumeurs et d’autres stratégies discursives dominaient la Martinique et la Guadeloupe, malgré le désir colonial de fixer à la fois l’identité des colonisés et la signifiance des événements contemporains. Cet article va se servir de la notion plutôt déconstructive de Judith Butler à propos de la censure pour examiner les stratégies discursives effectuées par les colonisateurs et les colonisés franco-antillais; le but va être d’illustrer l’interdépendance et la co-création de la signifiance dans ce contexte d’incertitude et de désir pour l’accès à l’information.
Bengal: The French connection
Authors: Majumdar Margaret A.
Published: November 2013

The subject of this article is the relationship between France and Bengal. It concentrates on the specific characteristics that distinguish the French connection with Bengal from that of other French territories in India. It briefly traces the history of the French presence in Chandernagore, before focusing on the early twentieth century and the important role that Chandernagore played in the Indian independence movement. It examines the practical effects on this struggle of the presence of the French in this part of India. Beyond these, it questions the extent of French influence on the political theory and practice of the Bengali revolutionaries. It ends more broadly by assessing the French legacy in Bengal today.

Cet article traite des rapports entre la France et le Bengale. Il souligne les aspects spécifiques qui relèvent de la situation particulière de Chandernagore et qui sont à distinguer de ceux qui touchent d’autres territoires français, comme Pondicherry. Après avoir tracé rapidement l’histoire de la présence française à Chandernagore, il examine le rôle important que cette ville a pu jouer dans le mouvement indépendantiste de l’Inde, surtout au début du XXe siècle. Il s’agit des effets pratiques sur cette lutte de l’existence de ce territoire français tout proche de Calcutta et, au-delà, de la possibilité d’une influence française sur la théorie et la pratique politique des révolutionnaires bengalais. L’article se termine par une évaluation de l’héritage culturel de la France au Bengale contemporain.
Materiality, modernity and the dialectics of reading in Amin Maalouf’s Mediterranean
Authors: Doshi Neil
Published: November 2013

This article reads Amin Maalouf’s novel Léon l’Africain (1986) to address the relationship between fiction-writing and the broader notion of Mediterranean identity that Maalouf advocates in his critical work. Conventional readings consider the representation of the early-modern Mediterranean in Maalouf’s oeuvre as recuperating a lost, and mythical Mediterranean that sustains a political call for conflict resolution in the present. This article argues that such readings overlook the historical critique articulated in the novel, which dismisses the golden-age thinking of a peaceful Andalusia. Second, through focus on the mise en abyme of the writer in the novel -the protagonist Leon who writes the text – this article suggests that the novel models a ‘Mediterranean mode’ of writing that at once preserves the notion of Mediterranean connectivity while making visible possibilities for reflexive critique.

Cet article traite du roman Léon l’Africain (1986) d’Amin Maalouf pour examiner le rapport entre ses oeuvres littéraires et les concepts «d’identité méditerranéenne » que l’écrivain développe dans ses essais. En ce qui concerne la représentation de la Méditerranée du début de l’époque moderne dans ses textes, la critique actuelle a tendance à considérer que l’oeuvre de Maalouf reprend la vision d’une Méditerranée multiculturelle qui soutient ses efforts pour favoriser la paix dans cette région. Cet article suggère qu’une telle compréhension de sa démarche ignore l’esprit critique du roman qui en fait rejette l’idée d’un âge d’or de la Méditerranée. Suivant une analyse de la mise-en-abime de l’écrivain, c’est-à-dire une discussion du positionnement du protagoniste Léon comme écrivain, cet article suggère que le roman formule un modèle d’écriture méditerranéenne qui  à la fois préserve le concept d’une Méditerranée interconnectée, mais qui s’ouvre quand même à l’autocritique.
Changes in brown seaweed distributions in Lough Hyne, SW Ireland: a long-term perspective
Authors: Trowbridge Cynthia D. , Little Colin , Dlouhy-Massengale Brittney , Stirling Penny , Pilling Graham M.
Published: November 2013

Distributions of brown seaweeds (Phaeophyceae: Fucales, Laminariales and Tilopteridales) were surveyed in 2011 in Europe’s first marine reserve, Lough Hyne in SW Ireland, and compared with distributions from three historical surveys (1930, 1955 and 1980). The most salient phycological differences were the incursion of the low intertidal and shallow subtidal species Fucus serratus, Himanthalia elongata and Saccharina latissima into the north basin of the marine reserve after the recent mass mortality of the purple urchin (Paracentrotus lividus). Monitoring surveys (1990–2012) at ten sites in the lough indicated that populations of S. latissima peaked in 1994, abruptly crashed in 1996 and then slowly recovered. As well as documenting the expansion of kelp, our annual, whole-lough snorkel surveys (2004–2012) demonstrated the recent proliferation of the introduced Sargassum muticum and native Cystoseira foeniculacea. Although the causal role of top-down factors (fishing ban and/or urchin population crash), bottom-up factors (nutrient enhancement), climatic variables (warming vs. episodic cooling) and pathogens (urchin and algal) is being widely debated, decadal-scale and inter-annual changes are clearly detectable and most consistent with a release from herbivory within the marine protected area.
Determination of Flow Stress Using Parametric Linearity Relationship of Arrhenius Power Law
Authors: Maheshwari Amit Kumar
Published: November 2013

In this study, hot workability aspect for modeling the flow stress at specified deformation level is investigated. The proposed model contains the basic parametric relationship of Arrhenius power law. The developed mathematical model is validated on Al 2024 alloy to check its feasibility over a wide range of strain rate, strain, and temperature. When compared with Johnson-Cook (JC) model, it is found to give a more perceptible experimental output by limited evaluation of arbitrary constants. The proposed model uses the input from hot compression test without the necessacity to go to torsion experiment. This proves its supremacy over JC model which require both the inputs. It also limits the number of constants, so produces a forwarding mark to N.S. Babu Model which needs 48 numbers of constants to define the constitutive aspect of deformation.
Review of RT-LAB and Steps Involved for Implementation of a Simulink Model from MATLAB to REAL-TIME
Authors: Mikkili Suresh , Panda Anup Kumar
Published: November 2013

In recent days, every researcher wants to develop his/her model in real-time. Simulation tools have been widely used for the design and improvement of electrical systems since the mid-twentieth century. The evolution of simulation tools has progressed in step with the evolution of computing technologies. Now a days, computing technologies have improved dramatically in performance and become widely available at a steadily decreasing cost. Consequently, simulation tools have also seen dramatic performance gains and steady cost decreases. Researchers and engineers now have access to affordable, high-performance simulation tools that were previously too cost prohibitive, except for the largest manufacturers and utilities.This article has introduced a specific class of digital simulator known as a real-time simulator by answering the questions “What is real-time simulation?” “Why is it needed” and “How it works”. The latest trend in real-time simulation consists of exporting simulation models to FPGA. In this article, the steps involved for implementation of a model from MATLAB to REAL-TIME are provided in detail. The detailed real-time results are presented to support the feasibility of real-time digital simulator.
A Review and Advance Technology in Multi-Area Automatic Generation Control by Using Minority Charge Carrier Inspired Algorithm
Authors: Madichetty Sreedhar , Panda Susmita , Mishra Sambeet , Dasgupta Abhijit
Published: November 2013

This article deals with automatic generation control of a multi-area interconnected thermal system in different modes using intelligent integral and proportional-integral controllers. Appropriate generation rate constraint has been considered for the thermal generation plants. The two cumulated thermal areas are considered with reheat turbines. Performances of reheat turbine on dynamic responses have been investigated. Further, selection of suitable integral and proportional-integral controllers has been investigated with a minority charge carrier inspired algorithm. Cumulative system performance is examined considering with different load perturbation in both cumulative thermal areas. Further, system is investigated with different area control errors, and results are explored.
Genetic Architecture of Variation in the Lateral Line Sensory System of Threespine Sticklebacks
Authors: Wark Abigail R , Mills Margaret G , Dang Lam-Ha , Chan Yingguang Frank , Jones Felicity C , Brady Shannon D , Absher Devin M , Grimwood Jane , Schmutz Jeremy , Myers Richard M , Kingsley David M , Peichel Catherine L
Published: November 2013

Vertebrate sensory systems have evolved remarkable diversity, but little is known about the underlying genetic mechanisms. The lateral line sensory system of aquatic vertebrates is a promising model for genetic investigations of sensory evolution because there is extensive variation within and between species, and this variation is easily quantified. In the present study, we compare the lateral line sensory system of threespine sticklebacks (Gasterosteus aculeatus) from an ancestral marine and a derived benthic lake population. We show that lab-raised individuals from these populations display differences in sensory neuromast number, neuromast patterning, and groove morphology. Using genetic linkage mapping, we identify regions of the genome that influence different aspects of lateral line morphology. Distinct loci independently affect neuromast number on different body regions, suggesting that a modular genetic structure underlies the evolution of peripheral receptor number in this sensory system. Pleiotropy and/or tight linkage are also important, as we identify a region on linkage group 21 that affects multiple aspects of lateral line morphology. Finally, we detect epistasis between a locus on linkage group 4 and a locus on linkage group 21; interactions between these loci contribute to variation in neuromast pattern. Our results reveal a complex genetic architecture underlying the evolution of the stickleback lateral line sensory system. This study further uncovers a genetic relationship between sensory morphology and non-neural traits (bony lateral plates), creating an opportunity to investigate morphological constraints on sensory evolution in a vertebrate model system.
Location-Dependent Empirical Thresholds for Quantitative Trait Mapping
Authors: LaCombe Jason , McClosky Benjamin , Tanksley Steven
Published: November 2013

The Churchill-Doerge approach toward constructing empirical thresholds has received widespread use in the genetic mapping literature through the past 16 years. The method is valued for both its simplicity and its ability to preserve the genome-wide error rate at a prespecified level. However, the Churchill-Doerge method is not designed to maintain the local (comparison-wise) error rate at a constant level except in situations that are unlikely to occur in practice. In this article, we introduce the objective of preserving the local error rate at a constant level in the context of mapping quantitative trait loci in linkage populations. We derive a method that preserves the local error rate at a constant level, provide an application via simulation on a Hordeum vulgare population, and demonstrate evidence of the relationship between recombination and location bias. Furthermore, we indicate that this method is equivalent to the Churchill-Doerge method when several assumptions are satisfied.
Faith Community Nursing: Health and Healing within a Spiritual Congregation
Authors: Pappas-Rogich Maria , King Michalene
Published: November 2013

Originally named parish nursing because of its beginnings in the Christian faith, the term faith community nursing (FCN) has been adopted to encompass nurses from other faiths. The American Nurses Association recognized parish nursing as a nursing specialty and, in collaboration with the Health Ministries Association, published the Scope and Standards of Parish Nursing Practice in 1998 (revised in 2005). In this article, the authors explore the philosophy, objectives, growth, and practice of this specialty.
Not Changing Minds but Softening Hearts
Authors: Morey Jerad
Published: November 2013

When a political decision threatened to divide communities, the Minnesota Council of Churches found a way not to change minds but to soften hearts. The Respectful Conversations Project built empathy and improved relationships, and is still helping to bring peace to communities and strengthening civic engagement in the state.