bluuebunny/crossref_metadata_2025 huggingface dataset:
T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes
Authors: Distefano Rebecca , Ilieva Mirolyuba , Madsen Jens Hedelund , Ishii Hideshi , Aikawa Masanori , Rennie Sarah , Uchida Shizuka
Published: May 2023

Type II diabetes (T2D) is a growing health problem worldwide due to increased levels of obesity and can lead to other life-threatening diseases, such as cardiovascular and kidney diseases. As the number of individuals diagnosed with T2D rises, there is an urgent need to understand the pathogenesis of the disease in order to prevent further harm to the body caused by elevated blood glucose levels. Recent advances in long non-coding RNA (lncRNA) research may provide insights into the pathogenesis of T2D. Although lncRNAs can be readily detected in RNA sequencing (RNA-seq) data, most published datasets of T2D patients compared to healthy donors focus only on protein-coding genes, leaving lncRNAs to be undiscovered and understudied. To address this knowledge gap, we performed a secondary analysis of published RNA-seq data of T2D patients and of patients with related health complications to systematically analyze the expression changes of lncRNA genes in relation to the protein-coding genes. Since immune cells play important roles in T2D, we conducted loss-of-function experiments to provide functional data on the T2D-related lncRNA USP30-AS1, using an in vitro model of pro-inflammatory macrophage activation. To facilitate lncRNA research in T2D, we developed a web application, T2DB, to provide a one-stop-shop for expression profiling of protein-coding and lncRNA genes in T2D patients compared to healthy donors or subjects without T2D.
Molecular Oxygen Levels and Percentages of DNA Damage in TPN Patients
Authors: Dąbrowska Karolina , Zaczek Zuzanna , Panczyk Mariusz , Osowska Sylwia , Kowalczyk Paweł , Kramkowski Karol , Sobocki Jacek
Published: May 2023

Total parenteral nutrition (TPN) is a life-saving therapy for patients with intestinal failure, but it carries the risk of complications, including an increase in liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) after long-term use. Patients receiving chronic TPN are also exposed to metabolic stress from both the underlying disease and parenteral nutrition. The aim of this study was to compare the concentration of liver transaminases AST and ALT in relation to the rate of oxygen consumption in platelet mitochondria in patients receiving long-term TPN with the degree of oxidative stress induced by lipid emulsions, and to explain their role in cellular energy metabolism and changes in the liver based on the percentage of genomic DNA damage. The study group consisted of 86 TPN patients, while the control group consisted of 86 healthy volunteers who were fed only orally. The results of the study showed that the percentage of molecular oxygen depended on the type of lipid emulsion supplied. Analyzing time on TPN as a factor, we observed a decrease in percentage genomic DNA damage and an increase in percentage molecular oxygen in cells. It remains unclear whether TPN has a direct effect on genomic DNA damage and the level of molecular oxygen in cells during the course of treatment. In conclusion, this study provides important insights into the potential effects of TPN on liver enzymes and cellular metabolism. Further research is needed to better understand the underlying mechanisms and to develop strategies to minimize the risk of complications associated with TPN.
Guided Metabolic Detoxification Program Supports Phase II Detoxification Enzymes and Antioxidant Balance in Healthy Participants
Authors: Panda Chinmayee , Komarnytsky Slavko , Fleming Michelle Norton , Marsh Carissa , Barron Keri , Le Brun-Blashka Sara , Metzger Brandon
Published: May 2023

Adequate antioxidant supply is essential for maintaining metabolic homeostasis and reducing oxidative stress during detoxification. The emerging evidence suggests that certain classes of phytonutrients can help support the detoxification process by stimulating the liver to produce detoxification enzymes or acting as antioxidants that neutralize the harmful effects of free radicals. This study was designed to examine the effects of a guided 28-day metabolic detoxification program in healthy adults. The participants were randomly assigned to consume a whole food, multi-ingredient supplement (n = 14, education and intervention) or control (n = 18, education and healthy meal) daily for the duration of the trial. The whole food supplement contained 37 g/serving of a proprietary, multicomponent nutritional blend in the form of a rehydratable shake. Program readiness was ensured at baseline using a validated self-perceived wellness score and a blood metabolic panel, indicating stable emotional and physical well-being in both groups. No significant changes or adverse effects were found on physical or emotional health, cellular glutathione (GSH) and the GSH:GSSG ratio, porphyrin, and hepatic detoxification biomarkers in urine. The intervention was positively associated with a 23% increase in superoxide dismutase (p = 0.06) and a 13% increase in glutathione S-transferase (p = 0.003) activities in the blood. This resulted in a 40% increase in the total cellular antioxidant capacity (p = 0.001) and a 13% decrease in reactive oxygen species (p = 0.002) in isolated PBMCs from participants in the detoxification group. Our findings indicate that consuming a whole food nutritional intervention as a part of the guided detoxification program supported phase II detoxification, in part, by promoting enhanced free radical scavenging and maintaining redox homeostasis under the body’s natural glutathione recycling capacity.
An Evolving Definition of a “Healthy Diet”
Authors: Cicero Arrigo F. G. , Fogacci Federica , Borghi Claudio
Published: May 2023

Throughout life, most of us eat at least three meals a day for 365 days a year [...]
Young Japanese Underweight Women with “Cinderella Weight” Are Prone to Malnutrition, including Vitamin Deficiencies
Authors: Iizuka Katsumi , Sato Hiroko , Kobae Kazuko , Yanagi Kotone , Yamada Yoshiko , Ushiroda Chihiro , Hirano Konomi , Ichimaru Satomi , Seino Yusuke , Ito Akemi , Suzuki Atsushi , Saitoh Eiichi , Naruse Hiroyuki
Published: May 2023

Undernutrition among young women at “Cinderella weight” is socially important in Japan. To determine the nutritional status of Cinderella-weight women, we conducted an exploratory cross-sectional study on the health examination results of employees aged 20 to 39 (n = 1457 and 643 for women and men, respectively). The percentage of underweight women was found to be much higher than that of men (16.8% vs. 4.5%, respectively). In underweight women (n = 245), handgrip strength (22.82 ± 5.55 vs. 25.73 ± 5.81 kg, p < 0.001), cholesterol level (177.8 ± 25.2 vs. 194.7 ± 31.2 mg/dL, p < 0.05), and lymphocyte count (1883 ± 503 vs. 2148 ± 765/μL, p < 0.001) were significantly lower than in overweight women (n = 116). Then, the BMI < 17.5 group (n = 44) was referred to the outpatient nutrition evaluation clinic. Lower prealbumin, cholesterol, and lymphocyte levels were also observed in 34%, 59%, and 32% of the patients, respectively. Regarding dietary characteristics, 32% of the underweight women in this study skipped breakfast, and 50% had low dietary diversity scores. Lower total energy intake, carbohydrate and fiber intake, and Ca and Fe intake were also observed in 90% of the patients. Deficiencies in vitamin B1, B12, D, and folate were diagnosed in 4.6%, 25%, 14%, and 98% of the patients, respectively. Thus, young underweight women may be prone to malnutrition.
Beta Cell Dysfunction in Youth- and Adult-Onset Type 2 Diabetes: An Extensive Narrative Review with a Special Focus on the Role of Nutrients
Authors: Serbis Anastasios , Giapros Vasileios , Tsamis Konstantinos , Balomenou Foteini , Galli-Tsinopoulou Assimina , Siomou Ekaterini
Published: May 2023

Traditionally a disease of adults, type 2 diabetes (T2D) has been increasingly diagnosed in youth, particularly among adolescents and young adults of minority ethnic groups. Especially, during the recent COVID-19 pandemic, obesity and prediabetes have surged not only in minority ethnic groups but also in the general population, further raising T2D risk. Regarding its pathogenesis, a gradually increasing insulin resistance due to central adiposity combined with a progressively defective β-cell function are the main culprits. Especially in youth-onset T2D, a rapid β-cell activity decline has been observed, leading to higher treatment failure rates, and early complications. In addition, it is well established that both the quantity and quality of food ingested by individuals play a key role in T2D pathogenesis. A chronic imbalance between caloric intake and expenditure together with impaired micronutrient intake can lead to obesity and insulin resistance on one hand, and β-cell failure and defective insulin production on the other. This review summarizes our evolving understanding of the pathophysiological mechanisms involved in defective insulin secretion by the pancreatic islets in youth- and adult-onset T2D and, further, of the role various micronutrients play in these pathomechanisms. This knowledge is essential if we are to curtail the serious long-term complications of T2D both in pediatric and adult populations.
Clinical Outcomes of the Deleterious Effects of Aluminum on Neuro-Cognition, Inflammation, and Health: A Review
Authors: Renke Guilherme , Almeida Vanessa Borges Pinheiro , Souza Everton Almeida , Lessa Suzana , Teixeira Raila Linhares , Rocha Leticia , Sousa Pamela Lopes , Starling-Soares Bernardo
Published: May 2023

Introduction: In the scenario of metal toxicity, aluminum (Al) stands out as a ubiquitous type of metal that can be combined with other elements and form different compounds. Al is widely used daily as an adjuvant in vaccines, antacids, food additives (as components of AI-containing food additives), skin care products, cosmetics, and kitchenware, and can be an element or contaminant present in our daily life. Objective: To present a review of the main deleterious effects of Al on human health. Methods: The search was carried out from September 2022 to February 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using scientific articles from 2012 to 2023. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusions: A total of 115 files were search returned. Further, 95 articles were evaluated, and 44 were included in this review. Based on the results, measuring Al’s relevance to health is essential in medicine. Several studies have demonstrated clinical outcomes and metabolic alterations with Al exposure. The tolerable weekly intake established by the European Food Safety Authority (EFSA) of 1 mg Al/kg body weight can be achieved through dietary exposure alone. Proven neurotoxicity in humans is the critical adverse effect of Al. A carcinogenic effect of Al has not been proven so far. Preventive medicine advocates that exposure to Al should be kept as low as possible. Chelating agents, such as calcium disodium ethylene diamine tetraacetic acid and deferoxamine, are options for acute poisoning, and monomethysilanetriol supplementation may be a long-term strategy with chelation potential. Further studies are needed to assess the impacts of Al on human health.
Nutrient-Dependent Mitochondrial Fission Enhances Osteoblast Function
Authors: Menale Ciro , Trinchese Giovanna , Aiello Immacolata , Scalia Giulia , Dentice Monica , Mollica Maria Pina , Yoon Nal Ae , Diano Sabrina
Published: May 2023

Background: The bone synthesizing function of osteoblasts (OBs) is a highly demanding energy process that requires nutrients. However, how nutrient availability affects OBs behavior and bone mineralization remain to be fully understood. Methods: MC3T3-E1 cell line and primary OBs (OBs) cultures were treated with physiological levels of glucose (G; 5.5 mM) alone or with the addition of palmitic acid (G+PA) at different concentrations. Mitochondria morphology and activity were evaluated by fluorescence microscopy, qPCR, and oxygen consumption rate (OCR) measurement, and OBs function was assessed by mineralization assay. Results: The addition of non-lipotoxic levels of 25 μM PA to G increased mineralization in OBs. G+25 μM PA exposure reduced mitochondria size in OBs, which was associated with increased activation of dynamin-related protein 1, a mitochondrial fission protein, enhanced mitochondria OCR and ATP production, and increased expression of oxidative phosphorylation genes. Treatment with Mdivi-1, a putative inhibitor of mitochondrial fission, reduced osteogenesis and mitochondrial respiration in OBs. Conclusions: Our results revealed that OBs function was enhanced in the presence of glucose and PA at 25 μM. This was associated with increased OBs mitochondrial respiration and dynamics. These results suggest a role for nutrient availability in bone physiology and pathophysiology.
Divergent Hantavirus in Somali Shrews (Crocidura somalica) in the Semi-Arid North Rift, Kenya
Authors: Omoga Dorcus C. A. , Tchouassi David P. , Venter Marietjie , Ogola Edwin O. , Rotich Gilbert , Muthoni Joseph N. , Ondifu Dickens O. , Torto Baldwyn , Junglen Sandra , Sang Rosemary
Published: May 2023

Hantaviruses are zoonotic rodent-borne viruses that are known to infect humans and cause various symptoms of disease, including hemorrhagic fever with renal and cardiopulmonary syndromes. They have a segmented single-stranded, enveloped, negative-sense RNA genome and are widely distributed. This study aimed to investigate the circulation of rodent-borne hantaviruses in peridomestic rodents and shrews in two semi-arid ecologies within the Kenyan Rift Valley. The small mammals were trapped using baited folding Sherman traps set within and around houses, then they were sedated and euthanatized through cervical dislocation before collecting blood and tissue samples (liver, kidney, spleen, and lungs). Tissue samples were screened with pan-hantavirus PCR primers, targeting the large genome segment (L) encoding the RNA-dependent RNA polymerase (RdRp). Eleven of the small mammals captured were shrews (11/489, 2.5%) and 478 (97.5%) were rodents. A cytochrome b gene-based genetic assay for shrew identification confirmed the eleven shrews sampled to be Crocidura somalica. Hantavirus RNA was detected in three (3/11, 27%) shrews from Baringo County. The sequences showed 93–97% nucleotide and 96–99% amino acid identities among each other, as well as 74–76% nucleotide and 79–83% amino acid identities to other shrew-borne hantaviruses, such as Tanganya virus (TNGV). The detected viruses formed a monophyletic clade with shrew-borne hantaviruses from other parts of Africa. To our knowledge, this constitutes the first report published on the circulation of hantaviruses in shrews in Kenya.
Synergistic Effect of Anethole and Platinum Drug Cisplatin against Oral Cancer Cell Growth and Migration by Inhibiting MAPKase, Beta-Catenin, and NF-κB Pathways
Authors: Semlali Abdelhabib , Ajala Ikram , Beji Sarra , Al-Zharani Mohammed Mousa , Rouabhia Mahmoud
Published: May 2023

Cisplatin is a common drug used to treat patients with oral squamous cell carcinoma. However, cisplatin-induced chemoresistance poses a major challenge to its clinical application. Our recent study has shown that anethole possesses an anti-oral cancer effect. In this study, we examined the combined effect of anethole and cisplatin on oral cancer therapy. Gingival cancer cells Ca9-22 were cultured in the presence of various concentrations of cisplatin with or without anethole. The cell viability/proliferation and cytotoxicity were evaluated, respectively, by MTT, Hoechst staining, and LDH assay, while colony formation was measured by crystal violet. Oral cancer cell migration was evaluated by the scratch method. Apoptosis, caspase activity, oxidative stress, MitoSOX, and mitochondrial membrane potential (ΔΨm) levels were evaluated by flow cytometry, and the inhibition of signaling pathways was investigated by Western blot. Our results show that anethole (3 µM) potentiates cisplatin-induced inhibition of cell proliferation and decreases the ΔΨm on Ca9-22 cells. Furthermore, drug combination was found to inhibit cell migration and enhanced cisplatin cytotoxicity. The combination of anethole and cisplatin potentiates cisplatin-induced oral cancer cell apoptosis through the activation of caspase, while we also found anethole and cisplatin to enhance the cisplatin-induced generation of reactive oxygen species (ROS) and mitochondrial stress. In addition, major cancer signaling pathways were inhibited by the combination of anethole and cisplatin such as MAPKase, beta-catenin, and NF-κB pathways. This study reports that the combination of anethole and cisplatin might provide a beneficial effect in enhancing the cisplatin cancer cell-killing effect, thus lowering the associated side effects.
Multifunctional Milk-Derived Small Extracellular Vesicles and Their Biomedical Applications
Authors: Zhong Youxiu , Wang Xudong , Zhao Xian , Shen Jiuheng , Wu Xue , Gao Peifen , Yang Peng , Chen Junge , An Wenlin
Published: May 2023

In recent years, small extracellular vesicles (sEVs) have been regarded as the next generation of novel delivery systems after lipid nanoparticles because of their advantages and huge prospects in drug delivery. Studies have shown that sEVs are abundant in milk and therefore can be a large and economical source of sEVs. Natural milk-derived small extracellular vesicles (msEVs) have important functions such as immune regulation, anti-bacterial infection, anti-oxidative, etc., and play a beneficial role in human health at multiple levels, including intestinal health, bone/muscle metabolism, and microbiota regulation. In addition, because they can pass the gastrointestinal barrier and have low immunogenicity, good biocompatibility, and stability, msEVs are considered a crucial oral drug delivery vehicle. Moreover, msEVs can be further engineered for targeted delivery to prolong the circulation time or enhance local drug concentrations. However, msEVs separation and purification, complex contents, and quality control hinder their application in drug delivery. This paper provides a comprehensive review of the biogenesis and characteristics, isolation and purification, composition, loading methods, and function of msEVs, based on which their applications in biomedical fields are further explored.
Preparation and In Vitro Characterization of Alkyl Polyglucoside-Based Microemulsion for Topical Administration of Curcumin
Authors: Scomoroscenco Cristina , Teodorescu Mircea , Nistor Cristina Lavinia , Gifu Ioana Catalina , Petcu Cristian , Banciu Daniel Dumitru , Banciu Adela , Cinteza Ludmila Otilia
Published: May 2023

The skin is a complex and selective system from the perspective of permeability to substances from the external environment. Microemulsion systems have demonstrated a high performance in encapsulating, protecting and transporting active substances through the skin. Due to the low viscosity of microemulsion systems and the importance of a texture that is easy to apply in the cosmetic and pharmaceutical fields, gel microemulsions are increasingly gaining more interest. The aim of this study was to develop new microemulsion systems for topical use; to identify a suitable water-soluble polymer in order to obtain gel microemulsions; and to study the efficacy of the developed microemulsion and gel microemulsion systems in the delivery of a model active ingredient, namely curcumin, into the skin. A pseudo-ternary phase diagram was developed using AKYPO® SOFT 100 BVC, PLANTACARE® 2000 UP Solution and ethanol as a surfactant mix; caprylic/capric triglycerides, obtained from coconut oil, as the oily phase; and distilled water. To obtain gel microemulsions, sodium hyaluronate salt was used. All these ingredients are safe for the skin and are biodegradable. The selected microemulsions and gel microemulsions were physicochemically characterized by means of dynamic light scattering, electrical conductivity, polarized microscopy and rheometric measurements. To evaluate the efficiency of the selected microemulsion and gel microemulsion to deliver the encapsulated curcumin, an in vitro permeation study was performed.
Lamivudine and Emtricitabine Dosing Proposal for Children with HIV and Chronic Kidney Disease, Supported by Physiologically Based Pharmacokinetic Modelling
Authors: Jacobs Tom G. , de Hoop-Sommen Marika A. , Nieuwenstein Thomas , van der Heijden Joyce E. M. , de Wildt Saskia N. , Burger David M. , Colbers Angela , Freriksen Jolien J. M.
Published: May 2023

Dose recommendations for lamivudine or emtricitabine in children with HIV and chronic kidney disease (CKD) are absent or not supported by clinical data. Physiologically based pharmacokinetic (PBPK) models have the potential to facilitate dose selection for these drugs in this population. Existing lamivudine and emtricitabine compound models in Simcyp® (v21) were verified in adult populations with and without CKD and in non-CKD paediatric populations. We developed paediatric CKD population models reflecting subjects with a reduced glomerular filtration and tubular secretion, based on extrapolation from adult CKD population models. These models were verified using ganciclovir as a surrogate compound. Then, lamivudine and emtricitabine dosing strategies were simulated in virtual paediatric CKD populations. The compound and paediatric CKD population models were verified successfully (prediction error within 0.5- to 2-fold). The mean AUC ratios in children (GFR-adjusted dose in CKD population/standard dose in population with normal kidney function) were 1.15 and 1.23 for lamivudine, and 1.20 and 1.30 for emtricitabine, with grade-3- and -4-stage CKD, respectively. With the developed paediatric CKD population PBPK models, GFR-adjusted lamivudine and emtricitabine dosages in children with CKD resulted in adequate drug exposure, supporting paediatric GFR-adjusted dosing. Clinical studies are needed to confirm these findings.
Establishment and Validation of a New Co-Culture for the Evaluation of the Permeability through the Blood–Brain Barrier in Patients with Glioblastoma
Authors: Sánchez-Dengra Bárbara , García-Montoya Elena , González-Álvarez Isabel , Bermejo Marival , González-Álvarez Marta
Published: May 2023

Currently, the mechanisms involved in drug access to the central nervous system (CNS) are not completely elucidated, and research efforts to understand the behaviour of the therapeutic agents to access the blood–brain barrier continue with the utmost importance. The aim of this work was the creation and validation of a new in vitro model capable of predicting the in vivo permeability across the blood–brain barrier in the presence of glioblastoma. The selected in vitro method was a cell co-culture model of epithelial cell lines (MDCK and MDCK-MDR1) with a glioblastoma cell line (U87-MG). Several drugs were tested (letrozole, gemcitabine, methotrexate and ganciclovir). Comparison of the proposed in vitro model, MDCK and MDCK-MDR1 co-cultured with U87-MG, and in vivo studies showed a great predictability for each cell line, with R2 values of 0.8917 and 0.8296, respectively. Therefore, both cells lines (MDCK and MDCK-MDR1) are valid for predicting the access of drugs to the CNS in the presence of glioblastoma.
An Erbium-Doped Fiber Source with Near-Gaussian-Shaped Spectrum Based on Double-Stage Energy Matching and LPFGs
Authors: Wan Shiyong , Zhan Tiankui , Hu Die , Yan Haitao , Han Daofu
Published: May 2023

An Erbium-doped fiber source with a near-Gaussian-shaped spectrum consisting of only a single peak, based on the double-stage energy matching and LPFGs, is proposed and demonstrated. A double-stage Erbium-doped fiber source system is built. The first-stage structure adopts the single-pass forward pumping method with a 15 m Erbium-doped fiber, while the second-stage structure adopts the backward-pumping method with a 26.5 m Erbium-doped fiber. The energy of the output spectrum is concentrated near the long wavelength (1560 nm) through the double-pump energy matching of the two stages. Long period fiber gratings (LPFGs) are used to filter the excess light near the short wavelength (1530 nm) in order to obtain a near-Gaussian-shaped spectrum consisting of only a single peak. The output power, pump conversion efficiency, line width, 3 dB bandwidth and mean wavelength of this near-Gaussian-shaped spectrum are tested and analyzed. When the pump powers of the first and second stages are 50 mW and 360 mW, respectively, the results show that a near-Gaussian-shaped spectrum with a power of 10.17 mW, spectral line width of 19.767 nm, and mean wavelength stability of −0.978 ppm/mW can be obtained. This research provides a method for the generation of a near-Gaussian-shaped spectrum with high output power and excellent mean wavelength stability, and it can produce multiple forms and energies of near-Gaussian-shaped spectra via this Erbium-doped fiber source.
Quantum Dot Lasers Directly Grown on 300 mm Si Wafers: Planar and In-Pocket
Authors: Feng Kaiyin , Shang Chen , Hughes Eamonn , Clark Andrew , Koscica Rosalyn , Ludewig Peter , Harame David , Bowers John
Published: May 2023

We report for the first time the direct growth of quantum dot (QD) lasers with electrical pumping on 300 mm Si wafers on both a planar template and in-pocket template for in-plane photonic integration. O-band lasers with five QD layers were grown with molecular beam epitaxy (MBE) in a 300 mm reactor and then fabricated into standard Fabry–Perot ridge waveguide cavities. Edge-emitting lasers are demonstrated with high yield and reliable results ready for commercialization and scaled production, and efforts to make monolithically integrated lasing cavities grown on silicon-on-insulator (SOI) wafers vertically aligned and coupled to SiN waveguides on the same chip show the potential for 300 mm-scale Si photonic integration with in-pocket direct MBE growth.
2D Saturable Absorbers for Potential Pulse Generation in the Visible-Wavelength Band
Authors: Peng Jian , Zhu Runlin , Shen Tianci , Liu Yuchun , Ma Yanna , Gu Fuxing
Published: May 2023

Implementing compact, efficient, and reliable passive pulsed lasers at visible wavelengths is attractive. This paper systematically investigated the thickness-dependent optical absorption characteristics of two-dimensional materials, including graphene, transition-metal dichalcogenides, and dye films at the 532 nm wavelength band, and revealed the effects of thickness on different optical absorption parameters. The results suggested that dye films are more suitable for loss-sensitive pulsed lasers and graphene is more suitable for modulation depth-sensitive pulsed lasers, while transition-metal dichalcogenide samples have intermediate performance. It can provide guidance for the rational selection of saturable absorbers in pulsed all-fiber lasers to optimize the optical pulse performance in the visible-wavelength band.
On the Application of an In Situ Catalyst Characterization System (ICCS) and a Mass Spectrometer Detector as Powerful Techniques for the Characterization of Catalysts
Authors: Yunes Simón , Kenvin Jeffrey , Gil Antonio
Published: May 2023

The in situ characterization of catalysts provides important information on the catalyst and the understanding of its catalytic performance and selectivity for a specific reaction. Temperature programmed analyses (TPX) techniques for catalyst characterization reveal the role of the support on the stabilization and dispersion of the active sites. However, these can be altered at high temperatures since sintering of active species can occur as well as possible carbon deposition which hinders the active species and deactivates the catalyst. The in situ characterization of the spent catalyst, however, may expose the causes of catalyst deactivation. For example, a simple temperature programmed oxidation (TPO) analysis on the spent catalyst may produce CO and CO2 via a reaction with O2 at high temperatures and this is a strong indication that deactivation may be due to the deposition of carbon. Other TPX techniques such as temperature programmed reduction (TPR) and pulse chemisorption are also valuable techniques when they are applied in situ to the fresh catalyst and then to the catalyst upon deactivation. In this work, two Ni supported catalysts were considered as examples to elucidate the importance of these techniques in the characterization study of catalysts applied to the reaction of hydrogenation of CO2.
On-Chip 3D Printing of Polymer Waveguide-Coupled Single-Photon Emitter Based on Colloidal Quantum Dots
Authors: Ngo Gia Long , Nguyen Long , Hermier Jean-Pierre , Lai Ngoc Diep
Published: May 2023

In the field of quantum technology, there has been a growing interest in fully integrated systems that employ single photons due to their potential for high performance and scalability. Here, a simple method is demonstrated for creating on-chip 3D printed polymer waveguide-coupled single-photon emitters based on colloidal quantum dots (QDs). By using a simple low-one photon absorption technique, we were able to create a 3D polymeric crossed-arc waveguide structure with a bright QD on top. These waveguides can conduct both excitation laser and emitted single photons, which facilitates the characterization of single-photon signals at different outputs with a conventional confocal scanning system. To optimize the guiding effect of the polymeric waveguide structures, comprehensive 3D finite-difference time-domain simulations were performed. Our method provides a straightforward and cost-effective way to integrate high-performance single-photon sources with on-chip photonic devices, enabling scalable and versatile quantum photonic circuits for various applications.
Formulation and Performance of NBR/CR-Based High-Damping Rubber Composites for Soundproof Using Orthogonal Test
Authors: Zeng Xiankui , Zhu Jinmei , Li Gaowei , Miao Qing , Sain Mohini , Jian Ranran
Published: May 2023

Multiple functional-material-filled nitrile butadiene rubber/chloroprene rubber (NBR/CR) acoustic composites were extensively studied and prepared. According to the orthogonal test table L25 (56), 25 groups of samples were prepared by using a low-temperature one-time rubber mixing process. With tensile strength, average transmission loss, and damping peak as indexes, the influence degree of different factors and levels on the properties of acoustic composites was quantitatively discussed and analyzed. The matrix weight analysis was employed to optimize the material formula of rubber composites, and the corresponding influence weight was given. Results showed that the acoustic composite with blending ratio of 70/30 for NBR/CR matrix had preferable mechanical and acoustic properties; adding mica powder (MP) and montmorillonite (MMT) in matrix contributed to improve all above three indexes owing to their specific lamellar structures; hollow glass beads (HGB) had a positive influence on improving acoustic property due to its hollow microcavities, however, it had a negative impact on damping property because of the smooth spherical surfaces. Accordingly, the optimal formulation was found to be NBR/CR blending ratio of 70/30, MP of 10 phr (per hundred rubber), HGB of 4 phr, and MMT of 10 phr.
Nafion: New and Old Insights into Structure and Function
Authors: Ninham Barry W. , Battye Matthew J. , Bolotskova Polina N. , Gerasimov Rostislav Yu. , Kozlov Valery A. , Bunkin Nikolai F.
Published: May 2023

The work reports a number of results on the dynamics of swelling and inferred nanostructure of the ion-exchange polymer membrane Nafion in different aqueous solutions. The techniques used were photoluminescent and Fourier transform IR (FTIR) spectroscopy. The centers of photoluminescence were identified as the sulfonic groups localized at the ends of the perfluorovinyl ether (Teflon) groups that form the backbone of Nafion. Changes in deuterium content of water induced unexpected results revealed in the process of polymer swelling. In these experiments, deionized (DI) water (deuterium content 157 ppm) and deuterium depleted water (DDW) with deuterium content 3 PPM, were investigated. The strong hydration of sulfonic groups involves a competition between ortho- and para-magnetic forms of a water molecule. Deuterium, as it seems, adsorbs competitively on the sulfonic groups and thus can change the geometry of the sulfate bonds. With photoluminescent spectroscopy experiments, this is reflected in the unwinding of the polymer fibers into the bulk of the adjoining water on swelling. The unwound fibers do not tear off from the polymer substrate. They form a vastly extended “brush” type structure normal to the membrane surface. This may have implications for specificity of ion transport in biology, where the ubiquitous glycocalyx of cells and tissues invariably involves highly sulfated polymers such asheparan and chondroitin sulfate.
Experimental Study on Shear-Peeling Debonding Behavior of BFRP Sheet-to-Steel Interfaces
Authors: Xue Hanyang , Cao Dafu , Tang Zhanzhan , Liu Qing , Zhu Siji , Liu Jiaqi , Sun Chuanzhi
Published: May 2023

In order to study the failure mode and debonding behavior of the interface between BFRP (basalt fiber reinforced polymer) sheet and structural steel under mixed-mode loading conditions, eighteen specimens with different initial angles were tested in this study. The specimens were designed with different initial angles to ensure that the interface performed under mixed-mode loading conditions. The relations between the bond strengths, failure modes, and initial angles were investigated. A new evaluation method to predict the interfacial bond strength under shear-peeling loading mode was proposed. The test results show that specimens with a smaller initial angle are more likely to exhibit a shear debonding failure at the interface between the steel plate and adhesive. In contrast, specimens with a larger initial angle are more likely to exhibit peeling of the interface. The ultimate tensile strength of the specimen is higher with a smaller initial angle. The results predicted by the proposed method are in good agreement with the experimental results.
Screening the Impact of Surfactants and Reaction Conditions on the De-Inkability of Different Printing Ink Systems for Plastic Packaging
Authors: Guo Jinyang , Luo Cong , Wittkowski Christian , Fehr Ingo , Chong Zhikai , Kitzberger Magdalena , Alassali Ayah , Zhao Xuezhi , Leineweber Ralf , Feng Yujun , Kuchta Kerstin
Published: May 2023

One of the major applications (40% in Europe) of plastic is packaging, which is often printed to display required information and to deliver an attractive aesthetic for marketing purposes. However, printing ink can cause contamination in the mechanical recycling process. To mitigate this issue, the use of surfactants in an alkaline washing process, known as de-inking, has been employed to remove printing ink and improve the quality of recyclates. Despite the existence of this technology, there are currently no data linking the de-inking efficiency with typical printing ink compositions. Additionally, it is necessary to investigate the de-inking process under the process parameters of existing recycling plants, including temperature, NaOH concentration, and retention time. This study aims to evaluate the performance of commonly used printing inks with different compositions under various washing scenarios for plastic recycling in conjunction with different de-inking detergents containing surfactants or mixtures of surfactants. The results indicate that the pigments applied to the ink have no significant effect on the de-inking process, except for carbon black (PBk 7). Nitrocellulose (NC) binder systems exhibit high de-inkability (over 95%) under the condition of 55 °C and 1 wt.% NaOH. However, crosslinked binder systems can impede the de-inking effect, whether used as a binder system or as an overprint varnish (OPV). The de-inking process requires heating to 55 °C with 1 wt.% NaOH to achieve a substantial effect. Based on the findings in this work, breaking the Van der Waals forces, hydrogen bonds, and covalent bonds between the printing ink and plastic film is an essential step to achieve the de-inking effect. Further research is needed to understand the interaction between surfactants and printing inks, enabling the development of de-inkable printing inks and high-performance surfactants that allow for de-inking with less energy consumption. The surfactant and NaOH have a synergistic effect in cleaning the printing ink. NaOH provides a negative surface charge for the adsorption of the cationic head of the surfactant and can hydrolyze the covalent bonds at higher concentrations (>2 wt.%).
Modification of Macromolecules of Polyimide Films by Electron Irradiation
Authors: Abdulkarimova Roza , Muradov Abyl , Mukashev Kanat , Yar-Mukhamedova Gulmira , Japashov Nursultan
Published: May 2023

New polymeric materials formation by controlling their properties is the primary and most challenging problem in developing a methodology for synthesizing a chosen technology and its use. The combined effect of high-energy electron radiation and tensile stress will cause a decrease in crystallinity and the breakage of chemical bonds in polyimide film macromolecules and is a new approach in their production technology. The effect of uniaxial tension and electron irradiation on the modification of polyimide film at room temperature was studied. Irradiation of the films caused an increase in the intensity of the IR spectrum by ~2–6 times and an increase in the width of the bands. The intensity in the range of 1700–3500 cm−1 increased, indicating an increase in the content of radicals as a result of irradiation. The amplitudes of the electron paramagnetic resonance signal from non-irradiated films increased from 3 × 103 to 5 × 103 as a result of uniaxial tension to fracture, indicating an increase in radicals in the material. The lines of the electron paramagnetic resonance spectrum shifted from 3475.0 cm−1 to 3512.5 cm−1, with a simultaneous decrease in the signal’s amplitude from 6 ×103 to 4 × 103, as a result of the electron irradiation of the films, followed by their subjection to tension. This was due to a decrease in the concentration of the radicals of the =N-H and –N-H2 groups until their disappearance and the formation of new ones.
Review of Two-Dimensional MXenes (Ti3C2Tx) Materials in Photocatalytic Applications
Authors: Yu Haidong , Jiang Haibing , Zhang Shuji , Feng Xin , Yin Song , Zhao Wenzhi
Published: May 2023

MXenes (Ti3C2Tx) have gotten a lot of interest since their discovery in 2011 because of their distinctive two-dimensional layered structure, high conductivity, and rich surface functional groups. According to the findings, MXenes (Ti3C2Tx) may block photogenerated electron-hole recombination in the photocatalytic system and offer many activation reaction sites, enhancing the photocatalytic performance and demonstrating tremendous promise in the field of photocatalysis. This review discusses current Ti3C2Tx-based photocatalyst preparation techniques, such as ultrasonic mixing, electrostatic self-assembly, hydrothermal preparation, and calcination techniques. We also summarised the advancements in photocatalytic CO2 reduction, photocatalytic nitrogen fixation, photocatalytic hydrogen evolution, and Ti3C2Tx-based photocatalysts in photocatalytic degradation of pollutants. Lastly, the challenges and prospects of Ti3C2Tx in photocatalysis are discussed based on the practical application of Ti3C2Tx.
Effect of Crude Oil and Nitrogen Gas Flow Rates on the Time Taken for Flow Initiation of Waxy Crude Oil
Authors: Hussain Haizatul , Sulaiman Shaharin , Chala Girma , Husin Hazlina
Published: May 2023

Transportation of waxy crude oil in a production pipeline often encountered flow assurance issues, such as wax deposition. In a case where pipeline shutdown is needed, wax deposit is likely to form within the pipelines, which leads to operational complexity during the restart phase. Commonly, crude oil restarts to flow after a significantly high restart pressure is pumped longer than is necessary. This is due to the physical hindrance caused by the solid wax, which requires additional pressure to disintegrate it before achieving a steady crude oil flow. This study aims to investigate the effect of crude oil and nitrogen gas flow rates on the time taken for crude oil flow initiation using a flow loop rig, which is connected to a nitrogen gas injection system. The nitrogen gas was injected into the test section pipeline at predetermined flow rates within specified periods. After 45 min of static cooling, the crude oil gear pump is switched on to build sufficient pressure to initiate the waxy crude oil flow in the pipeline. Additionally, a statistical analysis by the response surface methodology was also performed by Minitab® 19 software. Results show that the maximum reduction in flow initiation is 73.7% at 5 L/min of crude oil and 1 L/min of nitrogen gas. This study reveals that the presence of nitrogen gas improved the pipeline restart phase by minimizing both restart pressure and time taken for flow initiation.
Psychopathology Present in Women after Miscarriage or Perinatal Loss: A Systematic Review
Authors: Díaz-Pérez Elisa , Haro Gonzalo , Echeverria Iván
Published: May 2023

Miscarriage or perinatal loss constitutes one of the most important emotional stressors a woman can experience and can be associated with bereavement. This mourning is a way of adapting and coping with the circumstances. However, inadequate management of this process can lead to the development of complicated grief and psychopathologies such as anxiety, depression, and post-traumatic stress disorder. The aim of this systematic review was to evaluate the prevalence of psychopathology (anxiety, depression, and post-traumatic stress disorder) in women with a history of miscarriage or perinatal loss in the year prior, and to compare these results with women without this history. A peer review was conducted in PubMed, Cochrane, Scopus, and Web of Science databases. We included (1) articles that included women of any age who had had a miscarriage or perinatal loss in the year prior, and (2) articles with a longitudinal cohort design with a comparison group of women without a history of miscarriage or perinatal loss. After the screening process, three articles met these inclusion criteria and were included in this study. Psychopathology in women after miscarriage or perinatal loss was higher than in the control groups. In addition, it was observed that these psychopathologies gradually decreased over the first year from the loss. In conclusion, abortion and perinatal loss pose a risk factor for the development of psychopathology. Therefore, we emphasize the importance of implementing a mental health plan for these women.
Witch Hunting and Prosecuting in Early Modern Italy: A Historiographical Survey
Authors: Valente Michaela
Published: May 2023

This article critically assesses Italian scholarship on the history of witchcraft over the last 60 years. Beginning with Carlo Ginzburg’s influential Night Battles (published in 1966 and translated to English in 1983) and ending with the recent work of Matteo Duni, Tamar Herzig, Vincenzo Lavenia and Louise Nyholm Kallestrup, the article traces the intellectual contexts and shifts in historiographical debates.
The Bishop’s Conscience: Pietro Camaiani, Cosimo I, and the Residency Debate at the Council of Trent, 1562–63
Authors: Amato J. G.
Published: May 2023

The third phase of the Council of Trent (1562–63) witnessed a crisis erupt over whether bishops resided in, and ruled, their dioceses de iure divino (by divine right) or by papal authority. Cosimo I de’ Medici, the Duke of Florence, cooperated with instructions from Pope Sixtus IV to send the Tuscan bishops to Trent, to vote as a bloc for Episcopal residency by papal authority. This position strengthened papal primacy and weakened bishops’ claims to autonomy. Pietro Camaiani, the Bishop of Fiesole and a longstanding Medici loyalist, defied the Duke’s instructions, claiming his freedom of conscience and episcopal liberty. Through an examination of diplomatic and personal correspondence, treatises, and judicial documents, I argue that there are three reasonable causes that influenced Camaiani to support episcopal residency de iure divino, in defiance of his patron Cosimo I. These include, the episcopalist theological arguments circulating at the Council, the heterodox literature of the 1540s, and his own lived experience as the Bishop of Fiesole. I uncover the challenges Camaiani faced while governing his diocese that brought him into conflict with Cosimo I, explore the political dimensions of episcopacy by papal authority, and problematize the meaning of Trent’s “ideal bishop.”
Influence of Wave-Induced Radiation Stress on Upper-Layer Ocean Temperature during Typhoons
Authors: Wang Qianhui , Shi Jian , Xia Jingmin , Han Kaifeng , Xiao Wenbin , Zhang Wenjing , Wang Haodi , Lv Jialei
Published: May 2023

Radiation stress is defined as the excess momentum caused by ocean waves, which exerts an indispensable impact on the upper-layer ocean conditions as waves pass by. Previous research concentrated on sea surface cooling caused by typhoons. In this paper, we investigated the effect of wave-induced radiation stress on upper-layer ocean temperature (including sea surface temperature (SST) and mixed-layer temperature) under typhoon conditions, as well as the effect of radiation stress on the surface current field. The FVCOM-SWAVE model, which is based on the SWAN model, is used to simulate the response of upper-layer ocean temperature to radiation stress. The simulated results, when validated with Jason-3 satellite and ARGO data, could reproduce the observed phenomenon well in general. Compared to simulations without radiation stress, the bias in the SST results is reduced by about 1 °C if the radiation stress term is taken into account. The mixed-layer depth temperature is expected to be simulated more accurately, with a root mean square error (RMSE) of less than 1.63 °C and a correlation coefficient (COR) of about 0.94. Results show that wave-induced radiation stress enhances the surface current and causes certain deviations to the right so that the upper water diverges and upwelling increases, resulting in a decrease in SST. When the influence of double typhoons is considered, the airflow of LEKIMA(L) rotates from the northwest toward KROSA (R), limiting the development of significant wave height (SWH) and reducing the cooling range. As a result, the present study is of tremendous importance in precisely forecasting the ocean state of the western North Pacific (WNP).
DF-UHRNet: A Modified CNN-Based Deep Learning Method for Automatic Sea Ice Classification from Sentinel-1A/B SAR Images
Authors: Huang Rui , Wang Changying , Li Jinhua , Sui Yi
Published: May 2023

With the goal of automatic sea ice mapping during the summer sea ice melt cycle, this study involved designing a fully automatic sea ice segmentation method based on a deep learning semantic segmentation network applicable to summer SAR images, which achieved high accuracy and the fully automatic extraction of sea ice segmentation during the summer ice melt cycle by optimizing the process, improving the pixel-level semantic segmentation network, and introducing high-resolution sea ice concentration features. Firstly, a convolution-based, high-resolution sea ice concentration calculation method is proposed and was applied to the deep learning task. Secondly, the proposed DF-UHRNet network was improved upon by designing high- and low-level fusion modules, introducing an attention mechanism, and reducing the number of convolution layers and other operations, and it can effectively fuse high- and low-scale semantic features and global contextual information based on reducing the overall number of network parameters, enabling it to achieve pixel-level classification. The results show that this method meets the needs associated with the automatic mapping and high-precision classification of thin ice, one-year ice, open water, and multi-year ice and effectively reduces the model size.