bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of lipoprotein lipase mutation in patients with severe hypertriglyceridemia and the characteristic features of hypertriglyceridemic pancreatitis
Authors: SOYALTIN Utku Erdem , KANDEMIR BOZKURT Ayşe Bengu , SOLMAZ Asli Ece , HAKVERDI Gulden , YILDIRIM SIMSIR Ilgin
Published: November 2022

Aim: We conducted a retrospective study with the aim of determining the prevalence of lipoprotein
lipase (LPL) mutation in patients with severe hypertriglyceridemia (HTG) and to study differences in
characteristic features of HTG induced acute pancreatitis (AP).
Materials and Methods: Seventy adults with a serum triglyceride (TG) level ≥500 mg/dL were
included in the study. Baseline characteristics, LPL mutation and risk factors between those with and
without HTG-AP were compared.
Results: The mean age was 43 ± 12 years, and males accounted for 55.7%. Of the patients 35 had
TG level <2000 mg/dL, and 35 patients had TG ≥2000 mg/dL. LPL mutation was found in 19 (27.1%)
of the cases. The prevalence of AP was 67.1% (47 patients). Younger age, TG level, hemoglobin A1c
(HbA1c) were significantly independent risk factors for the development of HTG-AP. When patients
were divided into groups based on TG levels (group 1 with TG <2000 mg/dL, group 2 TG ≥2000
mg/dL) the prevalence of AP was significantly higher in group 2 (51.4% vs. 82.9%). Age and HbA1c
lost their significance for development of AP. When the relationship between the frequency of AP and
TG value was evaluated, the specificity of TG threshold value for developing AP was found to be 2235
mg/dL. There was no difference in prevalence of AP and TG level between mutation detected and
undetected groups.
Conclusion: There was no difference in prevalence of AP and TG level between variant detected and
undetected groups. In contrast to the literature, higher levels of TG cut-off points to develop AP was
determined.
The evaluation of the neurocognitive development of the symptomatic West Syndrome patients
Authors: SARİGECİLİ Esra , MAKHAROBLİDZE Khatuna , KÖMÜR Mustafa , OKUYAZ Cengiz
Published: November 2022

Aim: Our study was aimed to determine both demographic and clinical data of patients with symptomatic West Syndrome (WS) and to monitor their neurocognitive development with Bayley Scales of Infant and Toddler Development Screening Test, third edition (Bayley-III) test. Materials and Methods: Fourteen symptomatic WS patients were included in our study. Clinical and demographic data, electroencephalogram (EEG) findings, treatment response, Bayley III developmental test results were recorded before starting the treatment (T0) and in the 12th months of the treatment (T1 and T12). Results: Patients had a significant increase in Bayley-III test scores in all areas at the end of one year (p <0.05). As the patients' EEGs improved, a statistically significant increase was observed in Bayley-III test scores in all areas (p <0.05). However, when the correlation between seizure control and the Bayley-III test scores were evaluated, there was an improvement only in the language area (p< 0,05); but there was no statistically significant difference in other brain areas (p> 0.05). Conclusion: It has been shown that the neurocognitive level gradually improves even in symptomatic type WS with effective treatment during the follow-up of the disease or with the improvement of the EEG findings and seizure control.
Potential of Orchids Secondary Metabolites as Anti-Cancer and Antimicrobial Based on Prediction of Phytochemical Activity with Online PASS-Software
Authors: Yasmin Rafida , Mafiroh Wulan Usfi , Kinasih Anggiresti , Ramadhani Aulia Noor , Putri Rachmi , Semiarti Endang
Published: November 2022

Abstract

Orchidology is part of the branch of botany, it deals with a large family of monocotyledonous plants, Orchidaceae. Orchids have been used as traditional herbal medicines in Indonesia which are believed to be antimicrobial and anti-cancer. Orchids are able to produce secondary metabolites as their protective agent due to the extreme environment. Orchids have great diversity and potential to be the object of research, not only in experimental studies but also in a computational studies like in silico. Nowadays, molecular or metabolite data are available on the official-standard website as an international database. This study was conducted by analyzing web-based data to provide information about the potential of orchids that have been trusted as herbal medicines. In this study, secondary metabolite from Vanilla spp., Dendrobium spp., and Vanda spp., were selected in the existing literature as antimicrobial and anti-cancer drugs. Secondary metabolites obtained from the KNApSAck-3D core system and Phytochemical and Prediction of Substance Activity Spectrum (PASS) were performed to determine the potential anti-cancer and antimicrobial activity. Based on in silico analysis through PASS online, the secondary metabolites of orchids that have potential as antimicrobials in this study were Dendroside E and Dendromonilised D from Dendrobium also Parviflorin, Licoisoflavone and Luteine ​​extracted from Vanda spp. The secondary metabolite of Vanilla planifolia which has potential as anti-cancer for further research is 4-Hydroxybenzoic acid as a Chlordecone reductase inhibitor extracted from shoots.  

Keywords: orchid, antimicrobial, anticancer, secondary metabolite, PASS online
DESCRIPTION OF NEW TERATOLOGICAL CASES INCLUDING CHROMATIC ABERRATIONS IN MUTILLIDAE (HYMENOPTERA VESPOIDEA)
Authors: TURRISI GIUSEPPE FABRIZIO , MATTEINI PALMERINI MAURIZIO , DEMETRIOU JAKOVOS , MATTEINI PALMERINI MARGHERITA , FORBICIONI LEONARDO
Published: November 2022

New teratological cases including one gynandromorph and chromatic aberrations of Mutillidae are described based on the examination of 27 specimens belonging to Myrmilla (Pseudomutilla) capitata (Lucas, 1848), Myrmilla (Myrmilla) erythrocephala (Latreille, 1792), Myrmilla (Pseudomutilla) glabrata (Fabricius, 1775), Mutilla europaea Linnaeus, 1758, Mutilla quinquemaculata Cyrillo, 1787, Ronisia barbara barbara (Linnaeus, 1758), Ronisia brutia brutia (Petagna, 1787), Tropidotilla litoralis (Petagna, 1787), Nemka viduata viduata (Pallas, 1773), Physetopoda cf. pusilla (Klug, 1835), Smicromyrme giarabubensis Invrea, 1932, Smicromyrme partitus partitus (Klug, 1835), Smicromyrme perisii (Sichel & Radoszkoswski, 1870), Smicromyrme ruficollis ruficollis (Fabricius, 1793), and Smicromyrme ruficollis ceresae Invrea, 1952. A brief account of data from scientific literature, as well a discussion on the ascertained cases are provided. Key Words: teratology, gynandromorphism, chromatic aberrations, Mutillidae, Palaearctic, description, discussion.
FURTHER INVESTIGATION ON THE MOSQUITOES (DIPTERA CULICIDAE) IN THE CAFFARELLA VALLEY, APPIA ANTICA REGIONAL PARK: FIRST RECORD OF CULEX THEILERI IN ROME, ITALY
Authors: CASALE FRANCESCA , SEVERINI FRANCESCO , MENEGON MICHELA , PICCARI FABRIZIO , GORI ROMINA , DELLA ROSA GIORGIO , DI LUCA MARCO , TOMA LUCIANO
Published: November 2022

From September 2020 to April 2021 a mosquito monitoring activity was carried out in the Caffarella Valley within the Appia Antica Regional Park in Rome, a very popular urban park completely surrounded by densely populated neighborhoods. During this entomological survey, we collected 798 mosquito larvae that were identified by morphology and by molecular tools. Out of these samples, eight taxa have been identified morphologically or molecularly in case of complex of species, belonging to five genera: Culex pipiens (49.1%, n=392), Culiseta annulata (16%, n=128), Culiseta longiareolata (13.1%, n=105), Anopheles claviger (11.5%, n=92), Aedes albopictus (5.5%, n=44), Anopheles maculipennis s.s. (2%, n=16), Culex theileri (0.7%, n=6), Uranotaenia unguiculata (1.8%, n=15). The noteworthy datum of this survey is the finding of Cx. theileri, a very common species in ponds and marshes in natural and rural environments, but never recorded before in Rome, and also the record of Ur. unguiculata, previously reported in Rome but never observed in this park. Caffarella Valley confirms its high degree of naturalness and high biodiversity in terms of mosquito species together to its particular location as a very popular urban park, completely surrounded by densely populated neighborhoods. Key Words: mosquitoes, Culex theileri, Rome, Italy
Reseña ao libro Innovación en educación: Gestión, currículo y tecnologías
Authors: Ortiz Macías Catalina Guadalupe
Published: November 2022

Reseña ao libro Innovación en educación: Gestión, currículo y tecnologías.
Penerapan Prinsip Vicarious Liability dalam Pertanggungjawaban Perseroan Terbatas
Authors: Afiftania Lana Aulia , Dian Purnama Anugerah
Published: November 2022

AbstractA limited liability company is a legal subject capable of being responsible for the risks in carrying out its business. The principle of vicarious liability is the basis of a person’s responsibility for acts against the law of others. One of these principles is applied in the employer’s responsibility to his subordinates. This research is a legal research that uses a statutory approach, a conceptual approach, and a case approach. This study aims to analyze the legal relationship between a limited liability company and an employee related to the principle of vicarious liability and the liability of a limited liability company in the consideration of the panel of judges. The results of this study indicate that a limited liability company is able to act as an employer and hiring employees. According to the principle of vicarious liability, the company will be responsible if an employee causes a loss during the performance of their duties. The panel of judges recognizes the principle of vicarious liability as the basis for corporate liability. There is a lot of diversity in the implementation of these principles. However, the important elements of the principle of vicarious liability are still reflected in the considerations of the panel of judges.Keywords: Liability; Limited Company; Vicarious Liability Principle.
AbstrakPerseroan terbatas merupakan subjek hukum yang mampu bertanggung jawab atas risiko dalam pelaksanaan usahanya. Prinsip vicarious liability merupakan dasar pertanggungjawaban seseorang atas perbuatan melawan hukum orang lain. Salah satu prinsip tersebut diterapkan dalam pertanggungjawaban majikan terhadap bawahannya. Penelitian ini merupakan penelitian hukum yang menggunakan pendekatan perundang-undangan (statute approach), pendekatan konseptual (conceptual approach), dan pendekatan kasus (case approach). Penelitian ini bertujuan untuk menganalisis hubungan hukum perseroan terbatas dan karyawan terkait prinsip vicarious liability serta pertanggungjawaban perseroan terbatas dalam pertimbangan majelis hakim. Hasil penelitian ini menyatakan bahwa perseroan terbatas mampu berkedudukan sebagai majikan dan mempekerjakan karyawan. Menurut prinsip vicarious liability, perseroan akan bertanggung jawab bilamana karyawan menimbulkan kerugian selama pelaksanaan tugasnya. Majelis hakim mengakui prinsip vicarious liability sebagai dasar pertanggungjawaban perseroan. Timbul banyak keberagaman dalam implementasi prinsip tersebut. Akan tetapi, unsur-unsur penting prinsip vicarious liability tetap tercermin dalam pertimbangan-pertimbangan majelis hakim.Kata Kunci: Pertanggungjawaban; Perseroan Terbatas; Prinsip Vicarious Liability.
State agencies and researchers engaging with indigenous communities on climate change adaptation planning: A systematic review
Authors:   University of Waikato, Masters-Awatere Bridgette , Young Patricia ,   University of Waikato, Graham Rebekah ,   University of Waikato
Published: November 2022

This systematic review centres planning, policy and/or strategic developments and implementation of climate change adaptation with Indigenous groups in Australia, Pacific Islands, Canada and the United States. We used PRISMA protocols to search five databases. The search was organised around three core areas: Indigenous people groups, climate change strategic planning, and Indigenous knowledge and active participation. A total of 6,338 articles from five databases were identified. Records were screened by title and abstract, leaving 87 articles that were assessed by full text. A total of 22 studies were included. The He Pikinga Waiora Implementation Framework was used as a matrix to analyse included articles. While studies included Indigenous groups in their research, most did not score highly for active inclusion of Indigenous knowledge, integrated knowledge translation or systems change. In general, studies had mediocre processes of inclusion that resulted in average responses and modest influence in decision-making forums
Caffeine, chocolate, and adenosine antagonism in Parkinson’s disease
Authors: Reichmann Heinz
Published: November 2022

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. It is generally accepted that dopamine replacement therapy substantially improves motor symptoms; however, there is a worldwide tendency to include nutrients in treatment strategies. In the present review, caffeine and chocolate are discussed. Caffeine use seems to postpone the occurrence of PD in men, and perhaps also in women who do not take postmenopausal hormone replacement therapy. There are contradictory data concerning possible caffeine-induced improvements in PD symptoms. Given that the basic action of caffeine is the antagonism of adenosine receptors, adenosine antagonists may be a new option for treating PD patients. Furthermore, PD patients tend to have increased chocolate consumption; this may be causally related to ingredients such as phenylethylamine. Thus, nutrients such as caffeine and chocolate may play an important role in postponing and/or improving symptoms in PD.
Corporate Social Responsibility on Twitter: A Review of Topics and Digital Communication Strategies’ Success Factors
Authors: Pilgrim Katharina , Bohnet-Joschko Sabine
Published: November 2022

Corporate social responsibility (CSR) has become increasingly important for companies in recent years. On the one hand, regulatory frameworks require the disclosure of measures for sustainable management. On the other hand, for long-term corporate success, stakeholders must be strategically engaged in the dialog on sustainability aspects. Social media, and Twitter in particular, offer the potential to foster a meaningful stakeholder dialogue on CSR topics. Due to Elon Musk's acquisition in the fall of 2022, this strategic disruption provides an opportunity to systematically capture the platform's past activities and strategies to synthesize practical information that can guide Twitter usage decision making and be used for research to serve as the basis for future comparative longitudinal studies of changes in usage. We conducted a literature review including 42 papers to contribute to the body of evidence on CSR communication strategies on Twitter across industries and countries by deriving interdisciplinary suggestions for strategic CSR-related stakeholder management. Results cover relevant CSR topics, prioritized stakeholder groups for CSR communication on Twitter and successful communication strategies for companies to obtain beneficial results, such as generating social media capital. The results contribute to the strategic planning and implementation of CSR stakeholder management on Twitter and offer starting points for future studies on social media mining and CSR communication strategies.
Exome Sequencing reveals characteristic KMT2C mutations in the Indian Phenotype of Cervical Cancer
Authors: Duppala Santosh Kumari , Kour Bhumandeep , Shukla Nidhi , Dhakane Maruti A , Mishra Ashwani Kumar , Digumarti Raghunadharao , Pawar Smita C , Suravajhala Prashanth N , Vuree Sugunakar
Published: November 2022

We attempted to understand the cervical cancer patient samples through Whole Exome Sequencing. We derived the variants from raw reads via our in-house benchmarked pipeline and validated the variants by IGV. This is the first cervical cancer exome data from the Indian cohort. Background: Cervical cancer (CC) is caused mainly by persistent infections of high-risk HPV, reduced parity, and factors like a decrease in average socioeconomic levels. We keep this because no cervical cancer exome data is available from the Indian cohort. Methods: The CC patient clinical samples were initially subjected to preparation using Qiagen DNA extraction, quantified, and the library preparation using the Agilent target enrichment system. Further, exome capture by Illumina platform (100X), quality check, alignment, and variant calling followed by the downstream analysis and finally visualized by IGV. Results: We observed a large number of SNVs or mutations from an Indian perspective, such as KMT2C, OR4M1, PDPR2P, EPHB1, FAS, OPCML, MGST1, C1QTNF9, HS6ST3, OR4K2, PRPSAP2, KCNJ12, FIGNL1, SFXN1, BAGE2, ARVCF, NAMPT variants of significance, unknown significance and possibly significant are reported. Conclusion: For the first time, KMT2C is observed as a novel potent mutation and pathogenic, showing the variant position at (7:152265091, T>A, SNV 62478356) from the Indian context in CC. Further, we visualized and validated the mutations using the Integrative Genomic Viewer (IGV) browser. Finally, we discuss the inherent challenges through KMT2C mutations.
Effect of Secondary Metabolite Crude of Metarhizum anisopliea Fungus on the Second Larval Stage of the Housefly Musca domestica
Authors: Kathiar Soolaf A , Al Shammari Hazim Idan , Hammed Aliaa Abdul Aziz
Published: November 2022

The house flies Musca domestica )Diptera:musidae) are the primary carrier of many pathogens such as cholera, typhoid, anthrax, and others. The use of chemical pesticides as a basic method of control leads to many problems at the environmental and health level. The use of safe alternatives to chemical pesticides has become an urgent necessity. The research aims to find biological alternatives that are environment-friendly and non-pathogenic to humans in controlling house flies through the possibility of extracting and diagnosing some secondary metabolites produced by the fungus Metarhizium anisopliae and testing their effects on the second larval stage of house flies using different treatment methods that include direct spraying of the larvae, treating the food environment, and the dipping method. Secondary metabolites and toxins of Metarhizium anisopliae were extracted in liquid media PDB using a mixture of organic solvents such as ethyl acetate and methanol. The secondary metabolites were identified by gas chromatography-mass spectrometry (GC-MS). The results showed the identification of 10 chemical compounds, including phenol, 2,4-bis(1,1-dimethylethyl (C14H22O)., Diethyl Phthalate (C12H14O4),  Hexadecanoic acid, methyl ester (C17H34O2 ),  Phthalic acid, butyl undecyl ester (C23H36O4) , 9,12-Octadecanoic (Z,Z )-, methyl ester ( C19H34O2),  9-Octadecanoic acid, methyl ester, (C19H36O2), 9,12,15-Octadecanoic acid,methyl ester,(Z,Z,Z) (C19H32O2), Octadecanoic acid,methyl ester(C19H38O2), Oleic Acid (C24H38O4), 9-Octadecanoic acid (Z)-,2-hydroxyl (hydroxymethyl) ethyl ester(C21H40O4) ,and Di-n-octyl phthalate (C24H38O4 ). The results showed that the crude extract of the fungus cause the best mortality rate  in the second instar larvae at concentrations of 3 and 5% after 72 hours of treatment when  the mortality rates ranged between 60-100%. The mortality rates were directly proportional to the increase in concentration and time with a significant difference. The results also showed that the treatment of the food media was the most effective in affecting the larvae of flies, recording mortality rates that reached 100%, with a significant difference with direct spraying and dipping methods. These results reveal the significant efficacy of the tested secondary metabolite crude of m.anesopalae against Musca domestica which could be used as an ecofriendly alternative for insect control.
A Security and Privacy Aware Computing Approach on Data Sharing in Cloud Environment
Authors: AL Mayyahi Mustafa Azeez , Seno Seyed Amin Hosseini
Published: November 2022

Today, the role of cloud computing in our day-to-day lives is very prominent. The cloud computing paradigm makes it possible to provide demand-based resources. Cloud computing has changed the way that organizations manage resources due to their robustness, low cost, and pervasive nature. Data security is usually realized using different methods such as encryption. However, the privacy of data is another important challenge that should be considered when transporting, storing, and analyzing data in the public cloud. In this paper, a new method is proposed to track malicious users who use their private key to decrypt data in a system, share it with others and cause system information leakage. Security policies are also considered to be integrated with the texts encrypted to ensure system safety and to prevent the violation of data owners ' privacy. For this purpose, before sending the data to the cloud, it must be encrypted in such a way that operations such as max, min, etc. can be performed on it. The proposed method uses order-preserving symmetric encryption (OPES), which does not require decryption or re-encryption for mathematical operations. This process leads to a great improvement in delay. The OPES scheme allows comparison operations to be performed directly on encrypted data without decryption operands. According to the results, it is obvious that the proposed strategy is in a better position compared to the base paper in terms of the system's ability to find the malicious elements that cause the problem of leakage and in terms of system security to prevent the violation of privacy.
Investigation of the Electron Coefficients of (Ar, He, N2, O2) Gases in the Ionosphere
Authors: Temur Aseel A. , Ahmed Ala F.
Published: November 2022

In this study, the electron coefficients; Mean energy , Mobility and Drift velocity  of different gases  Ar, He, N2 and O2  in the  ionosphere have been calculated using BOLSIG+ program to check the solution results of Boltzmann equation results, and effect of reduced electric field (E/N) on electronic coefficients. The electric field has been specified in the limited range 1-100 Td. The gases were in the ionosphere layer at an altitude frame 50-2000 km. Furthermore, the mean energy and drift velocity steadily increased with increases in the electric field, while mobility was reduced. It turns out that there is a significant and obvious decrease in mobility as a result of inelastic collisions and in addition little energy gained by the reduced electric field. A clear mathematical model was obtained to find out the electronic coefficient values without a simulation program (BOLSIG +). In addition, this model shows a strong correlation between the current work and the electronic transaction values calculated through the BOLSIG+ program.
An Evaluation of the Activity of Prepared Zinc Nanoparticles with Extracted Alfalfa Plant in the Treatment of Heavy Metals
Authors: Al-Bahadili Zainab Ridha , AL-Hamdani Abbas Ali Salih , Rashid Farqad Abdullah , Al-Zubaidi Labeeb Ahmed , Ibrahim Suha Mohamed
Published: November 2022

The alfalfa plant, after harvesting, was washed, dried, and grinded to get fine powder used in water treatment. We used the alfalfa plant with ethanol to make the alcoholic extract characterized by using (GC-Mass, FTIR, and UV) spectroscopy to determine active compounds. Alcoholic extract was used to prepare zinc nanoparticles. We characterized Zinc nanoparticles using (FTIR, UV, SEM, EDX Zeta potential, XRD, AFM). Zinc nanoparticle with Alfalfa extract and alfalfa powder were used in the treatment of water polluted with inorganic elements such as Cr, Mn, Fe, Cu, Cd, Ag by (Batch processing). The batch process with using alfalfa powder gets treated with Pb (51.45%), which is the highest percentage of treatment. Mn (13.18%), which is the lowest percentage of treatment. The batch process with using Zinc nanoparticles gets the result treated with Pb(98.822%), which is the highest percentage of treatment, and Mn (10.31%), which is the lowest percentage of treatment. When comparing alfalfa powder and zinc nanoparticle, it has been found that the treatment with zinc nanoparticle is more efficient in the removal of inorganic pollutants.
Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes
Authors: Sadiq Amaal S. , Khudhair Zahraa T. , Yousif Selvana A. , Mahmood Wasan A. R.
Published: November 2022

The target of this study was to synthesize several new Ciprofloxacin drug analogs by providing a nucleophilic substitution procedure that provides new functionality at the carboxylic group location. The analogs were synthesized, designed, and characterized by 1HNMR, and FTIR. The synthetic path began from the reaction of ciprofloxacin drug with morpholine to give compound[B], ciprofloxacin derivative was linked with a variety of primary and secondary amines to give compounds[B1-B9]. The above-mentioned prepared compounds [B3 and B5] were applied to liver enzymes, and the increase in the activity of these enzymes was observed. In addition, a theoretical study was conducted to study the energies and properties of the prepared compounds.
Proposed Framework for Official Document Sharing and Verification in E-government Environment Based on Blockchain Technology
Authors: Ghani Rana F. , Al-Karkhi Asia Ali Salman , Mahdi Shakir Mahmood
Published: November 2022

Progression in Computer networks and emerging of new technologies in this field helps to find out new protocols and frameworks that provides new computer network-based services. E-government services, a modernized version of conventional government, are created through the steady evolution of technology in addition to the growing need of societies for numerous services. Government services are deeply related to citizens’ daily lives; therefore, it is important to evolve with technological developments—it is necessary to move from the traditional methods of managing government work to cutting-edge technical approaches that improve the effectiveness of government systems for providing services to citizens. Blockchain technology is among the modern technologies highly suitable for developing digital governance services, and its technological ability to sustain information stability is vital in digital governance systems since it improves integrity and transparency measures while preventing corruption. In this study, computer networking protocols are built to form a peer-to-peer network framework for managing official documents. using blockchain technology was built to illustrate how any element of government work may be developed using it. The suggested framework comprises the addition of a new official document, and the verification of an existing document. The system was created in socket programming using Java and tested the response times for many simultaneous requests. The system was tested using transactions per second (throughput) measurement. The result showed that the proposed system processed 200 document verification transactions within 50 seconds. In addition, the test of the proposed system presented the time required for document retrieval—about three seconds to answer 100 document retrieval transactions. Furthermore, the results of throughput were compared to the results of the same measurement of some popular applications such as bitcoin. And the result of the proposed system was within the average value of output throughput of the other compared applications.
Normal Self-injective Hyperrings
Authors: Abood Mayssam Fadel , Ibrahiem Tamadher Arif
Published: November 2022

In this paper normal self-injective hyperrings are introduced and studied. Some new relations between this concept and essential hyperideal, dense hyperideal, and divisible hyperring are studied.
Strong father-child relationships and other positive childhood experiences, adverse childhood experiences, and sexual risk factors for HIV among young adults aged 19-24 years, Namibia, 2019: A Cross-sectional Study.
Authors: Agathis Nickolas Theophilos , Annor Francis B. , Xu Likang , Swedo Elizabeth , Chiang Laura , Coomer Rachel , Hegle Jennifer , Patel Pragna , Forster Norbert P. , O'Malley Gabrielle , Ensminger Alison L. , Kamuingona Rahimisa , Andjamba Helena , Nshimyimana Brigitte , Manyando Molisa , Massetti Greta M.
Published: November 2022

Background Understanding what childhood factors influence HIV acquisition risk among young adults, especially young women, is critical as they are disproportionately affected by the global HIV epidemic. Adverse and positive childhood experiences (ACEs and PCEs, respectively), including strong parent-child relationships, may influence HIV acquisition risk among youth (19–24 years) living in sub-Saharan African countries. Methods Using cross-sectional data from the 2019 Namibia Violence Against Children and Youth Survey, we assessed the associations between each of 4 PCEs (including having a strong father-child relationship, strong mother-child relationship, or strong caregiver monitoring and supervision, and ever attending secondary school) and ≥ 3 ACEs with 7 individual sexual HIV risk factors, through sex-stratified multivariable hierarchical models. Interaction terms between ≥ 3 ACEs and the relevant PCE were included in each model. For significant interaction terms, multivariable analyses were done stratifying among those with and without the PCE. Results Strong father-child relationships were inversely associated with 2 HIV risk factors among women (lifetime transactional sex [OR 0.4, 95% CI 0.2–0.7] and recent age-disparate sexual relationship [OR 0.3, CI 95% 0.2–0.5]) and significantly interacted with having ≥ 3 ACEs for 3 HIV risk factors among women and 1 among men. Among women without strong father-child relationships, having ≥ 3 ACEs was positively associated with not knowing a partner’s HIV status (OR 1.7, 95% CI 1.7–2.4) or infrequently using condoms (OR 1.4, 95% CI 1.0-2.1) in the past year, and ever having an STI (OR 2.3, 95% CI 1.2–4.6); among men without strong father-child relationships, ≥ 3 ACEs was positively associated with having multiple sexual partners in the past year (OR 3.5, 95% CI 1.9–6.4). Conversely, among women and men with strong father-child relationships, experiencing ≥ 3 ACEs was either not significantly, or inversely, associated with those risk factors. The other PCEs were significantly associated with ≤ 1 HIV risk factor and had no significant interaction terms. Conclusion Among youth in Namibia, strong child-father relationships may reduce HIV acquisition risk and mitigate the effect of childhood adversity on this risk. Improving parent and caregiver support may be an important strategy to reduce the impact of childhood adversity and aid global HIV epidemic control.
Rapid phase transition in 2D active pseudocrystals
Authors: Chen No , Lo Wei-Chang , Lo Chien-Jung
Published: November 2022

Active matter with continuous energy injection that exhibits various nonequilibrium emergent behaviors, such as swarming and motility induced phase separation, has been extensively studied in the past decades. Achieving desired patterns and phases in fabricating functional materials by assembling active matter is a rising and challenging direction. Nevertheless, the ossibility of a stably ordered structure of active matter remains elusive. Toward this goal, the interplay between the active force and the volume exclusion provides a new way to manipulate mechanical stability. Here, we demonstrate a new type of active, two dimensional (2D) pseudocrystal system consisting of arrays of active rods. The pseudocrystals with tetratic array demonstrate robust stability against the thermal noise. Increasing the active force leads to a phase transition from pseudocrystal to swarming via shear melting. In the traveling pseudocrystals, on the contrary, the synchronized movement of active rods reduces internal stresses and enhances the stability of pseudocrystals. Topological defects quickly propagate in the traveling pseudocrystals and assist the stability. The present framework provides innovative insights into potentially new designs and manipulations of active materials.
PACS numbers:
Impact of abnormal glucose metabolism on the early neurological outcome in acute ischemic stroke patients treated with intravenous thrombolysis
Authors: Wang Ling , Hu Ting , Wang Nuo , Liu Haiyan , Wu Tao , Bi Xiaoying , Cheng Qiantao
Published: November 2022

Background and purpose:
Abnormal glucose metabolism status (AGM), including prediabetes and diabetes mellitus (DM) have been reported to be an important predictor of poor functional outcome in patients experiencing acute ischemic stroke (AIS). However, conclusions of recent studies are inconsistent about which AGM status increases the risk of post-thrombolysis early neurological deterioration (END). The purpose of this study was to evaluate the impact of AGM status on the risk of post-thrombolysis early neurological outcomes. We further investigated the influence of previous glucose control of diabetic patients on the post-thrombolysis early neurological outcomes evaluation.
Methods:
Prediabetes was identified as glycosylated hemoglobin (HbAlc) (%) level within the range of 5.7%-6.4%, and diabetes mellitus (DM) was diagnosed based on prior history of diabetes or an HbAlc≥6.5% and patients with HbAlc less than 5.7% were classified as normal glucose metabolism (NGM). Diabetic patients with good PGC had HbAlc <7%, diabetic patients with poor PGC had HbAlc≥7%. END was defined as a National Institutes of Health Stroke Scale Score (NIHSS) ≥ 4, ENI was defined as a ≥4-point decrease in NIHSS score or a complete resolution of neurological deficits, between the time of admission and 24 hours after IV-rtPA.
Results
In total, 261 (32.7%) patients were diagnosed with prediabetes, 91 (11.4%) patients were DM had good PGC and 186 (23.3%) patients were DM had poor PGC. After adjusted for confounders, in model 1, DM with poor PGC associated with the increased risk of post-thrombolysis END and poor functional outcome at discharge (OR, 2.09; 95% CI, 1.220-3.579; P=0.007) (OR, 1.91; 95% CI, 1.165-3.133; P=0.010), both prediabetes and DM with poor PGC were less likely to experience post-thrombolysis ENI (OR, 0.58; 95% CI, 0.377-0.907; P=0.016) (OR, 0.43; 95% CI, 0.255-0.71; P=0.001); in model 2, further adjusted for admission hyperglycemia, the presence of diabetes and DM with poor PGC was still independently related to post-thrombolysis ENI (OR, 0.62; 95% CI, 0.400-0.969; P=0.036) (OR, 0.51; 95% CI, 0.282-0.923; P=0.026).
Conclusion
Prediabetes and DM with poor PGC might be two abnormal blood glucose metabolism states that affects post-thrombolysis early neurological outcome in AIS patients.
Event-based imaging velocimetry using pulsed illumination
Authors: Willert Christian E.
Published: November 2022

The paper addresses the shortcoming of current event-based vision (EBV) sensors in the context of particle imaging.Latency is introduced both on the pixel level as well as during read-out from the array and results in systemic timing errors when processing the recorded event data.Using pulsed illumination, the overall latency can be quantified and indicates an upper bound on the frequency response on the order of 10-20 kHz for the specific EBV sensor. In particle-based flow measurement applications, particles scattering the light from a pulsed light source operating below this upper frequency can be reliably tracked in time.Through the combination of event-based vision and pulsed illumination, flow field measurements are demonstrated at light pulsing rates up to 10 kHz in both water and air flows by providing turbulence statistics and velocity spectra.The described EBV-based velocimetry system consists of only an EBV camera and a (low-cost) laser that can be directly modulated by the camera, making the system compact, portable and cost effective.
Socioeconomic status impact Chinese youth’s internalizing problems: The risk role of psychological insecurity and cognitive fusion
Authors: Tao Zhiyuan , Wang Zhenhai , Lan Yilin , Zhang Wei
Published: November 2022

Background
Low socioeconomic status (SES) has been shown to be associated with more internalizing problems in youth, but the mechanism of this relationship, has not been investigated in Chinese families. We tested the hypotheses that this association would be mediated by the youth’s psychological insecurity, and that there would be a moderating effect of cognitive fusion.
Method
Senior middle school students (N = 780, ages 16–19, 54.45% girls) were recruited to complete a self-report a measure of SES, the anxious/depression subscales of the Youth Self-Report, the Security Questionnaire and the Cognitive Fusion Questionnaire. A moderated mediation model was tested in regression-based analyses.
Results
Results indicated that (1) psychological insecurity fully mediated the relationship between SES and adolescent internalizing problems; (2) high cognitive fusion adolescents show stronger positive association of psychological insecurity and internalizing problems; (3) cognitive fusion also moderated the mediated pathway.
Conclusions
Present results emphasize the important effect of a psychological security and resourced environment on adolescent development and adolescents’ excessive fusion with thoughts of overestimating interpersonal and environmental insecurity may strengthen the indirect pathway from SES to internalizing problems via psychological insecurity. The findings are discussed in terms of their possible practical application in acceptance and commitment therapy.
Equilibrium, Kinetics and Thermodynamic studies of Cr (VI), Pb (II) & Zn (II) biosorption using Sargassum Wightii
Authors: Yogeshwaran V , Priya A.K
Published: November 2022

The removal of heavy metal ions (Cr, Pb and Zn) present in aqueous solutions has been examined utilizing Sargassum Wightii (SW) - brown algae – as an organic adsorbent. The functional groups of SW were determined by FTIR analysis before and after heavy metal ion adsorption. Because of the strong Van der Walls forces, the SEM/EDX picture reveals the presence of heavy metal ions on the surface of the SW. The influence of adsorption was studied in different settings by adjusting the parameters of pH, SW dosage, metal ion concentration, time of contact and temperature. In addition, the thermodynamic and isotherm investigations were carried out in order to determine the adsorption process and its connection. It was found that by adding 0.3 N H2SO4, the maximal desorption rate was achieved. Around 99.6% of chromium ions, 89.27% of lead ions and 82.39% of zinc ions were removed from the synthetic solutions through batch mode of adsorption studies.
Design of a Wideband Highly-Efficient GaN HEMT Power Amplifier for Multi-Band Applications
Authors: Xuan Xuefei , Cheng Zhiqun , Zhang Zhiwei , Gong Tingwei , Le Chao
Published: November 2022

A distributed basic matching network (MN) designed method that can achieve multi-octave bandwidth and highly efficient PA for multi-band applications is presented in this letter. The distributed network unit with a left-rotating T-type structure is employed to construct the wideband MN, whose topology and circuit parameters are acquired through optimization. Finally, the impedance realized by the designed MN falls into the target impedance region obtained by load-pull and source-pull technology in the desired frequency band. For the proof of the method, a broadband highly-efficient PA has been designed, fabricated, and measured using commercialized GaN HEMT. The measured results show that the implemented PA achieves a bandwidth of 137.8% from 0.7 to 3.8 GHz. The drain efficiency is between 59% and 70% with an output power of greater than 39 dBm and a gain ranging from 9 to 12.1 dB.
The common fatty acids have a pheromone-like effect, improving the emotion in mice
Authors: Li Yuanhua , Li Yuanhua , Zhang Yao-Hua , Wang Wei-Chao , Wang Zhen-Shan , Zhang Jian-Xu
Published: November 2022

Fatty acids widely exist in some exocrine organs such as mammary glands, sweat glands and vaginas of mammals and have been exemplified to be appeasing pheromones in mammals. Here, we tested the possibility that fatty acids are common pheromones in mammals using mice that had few fatty acids in the main pheromone sources (eg.urine and preputial glands) of known pheromones. Five synthetic fatty acids were equally mixed to form a blend (MA) to be tested and a blend (MP) of hexadecanol and hexadecanol acetate of two identified male pheromones of mice was used as a control. Both MA and MP activated typical brain regions to perceive pheromones via. immunohistochemical staining. The numbers of c-Fos+ neurons activated by MA vs. MP were greater in the AOB and BNST, equal in VMH and smaller in the BLA. Chronic exposure to either MA or MP significantly reduced isolation-induced anxiety and improved sociality and exploring behavior. Especially, the mRNA expression of some behavior-related genes such as BDNF, GluN2B, DRD2, ERβ and 5HT2A was increased or showed a tendency to increase in hippocampus or mPFC of the mice after chronic exposure to either MA or MP. Our results suggested that some fatty acids might be common pheromones probably from the exocrine organs found in all mammals.
A New Quantum Soliton Inspired Swarm Optimization Algorithm for Multi-objective Optimization
Authors: Fallahi Saeed
Published: November 2022

This paper introduces a novel approach to extending the multi-objective particle swarm optimization algorithm (MOPSO) characterized by the quantum concept of particle-like solitons, which are the solutions of the quantum nonlinear Schrödinger equation. Considering the motion scenario of the present algorithm based on the corresponding probability density function of quantum solitons allows producing new particle positions that overcome the deficiency of particles readily gathering in identical solutions and escaping from local Parato front. We examine the proposed algorithm over a set of known benchmark functions to evaluate the efficiency. Moreover, to achieve a more comprehensive conclusion about the performance, we compare it with the results obtained by two different state-of-the-art multi-objective metaheuristics, namely multi-objective particle swarm optimization (MOPSO) and non-dominated sorting genetic algorithm (NSGA-II). The numerical experiments show that in terms of accuracy, convergence, diversity, and distribution, the proposed algorithm provides promising results compared with other existing multi-objective optimization algorithms.
Development of a Bayesian network model to differentiate between benign and malignant pulmonary nodules
Authors: Huang Wucui , Huang Ziyang , Zhang Bowen , Wang Lile , Zhu Xiaoli , Liu Pei
Published: November 2022

Objective: To develop a diagnostic prediction model for pulmonary nodules based on a Bayesian network (BN).
Methods: A total of 981 patients with pulmonary nodules were divided into benign and malignant groups on the basis of pathological findings. The patients’ clinical data, radiological features of pulmonary nodules, serum tumor biomarkers and follow-up information were collected. Sixteen related variables were screened out by univariate regression analysis to develop a BN model for pulmonary nodules. To evaluate the effectiveness of this BN model, it was compared with other machine learning models and clinical prediction models.
Results: Among the 981 patients, 334 had benign and 647 had malignant nodules. Sixteen variables were statistically significant between the two groups (p<0.05): age, history of tuberculosis, number of nodules, nodule location, maximum diameter, type, sign of lobulation, spiculation, pleural indentation, cavitation, vascular convergence, calcification, CEA, CYFRA21-1, interval between first and last follow-up, and change in the size of nodules during follow-up time. The BN model tested in this study performed well and its sensitivity, specificity and the area under the curve were 81.1%, 80.8% and 85.4%, respectively.
Conclusion: We developed a BN model that integrates clinical data, computed tomography characteristics and serum biomarkers, and predicts the probability of pulmonary nodules being benign or malignant. The BN model performs better than clinical prediction models in distinguishing between benign and malignant pulmonary nodules. The predictive performance of the BN model was similar to that of common machine learning models and clinical models in prediction. Our BN model overcomes the barriers to clinical application inherent to black-box machine learning models, and visualization of this BN model enhances ease of use for clinicians.
Markov Transiting Between Tax evaders and Government
Authors: Wang Yu kun , Zhang Li
Published: November 2022

The authors have requested that this preprint be removed from Research Square.
Importance of Trade Integration and Trade Complementarity inflow on the relationship between China and Europe & Central Asia
Authors: Shahzad Umer
Published: November 2022

The study aim is to investigate the Industrial, Agricultural, and Technological Bilateral Trade relationship between China and the Europe & Central Asia region over the period of 2000 to 2019 by employing the Revealed Comparative Advantage Index (RCA export), Trade Complementarity Index (TCI) and Trade Integration Index (TCD). The estimated results showed that there is a strong Bilateral Trade relationship between China and Europe & Central Asia. The estimated results of the Trade Complementarity Index (TCI) indicates that between 20 industries' product 17 have strong TCI between China and Europe, which showed that the export and import between China and Europe & Central Asia are matched, only three of the industries product, which are vegetable, Fuels, and Minerals are not matched strongly, the Trade Integration Index (TCD) between China and Europe from 2000 to 2019 is less than 1 that explains the Trade Integration Index between China and Europe are weak which give us knowledge that Chinese trade didn’t depend strongly on the Europe & Central Asia, estimated results of the Revealed Comparative Advantage Index (RCA export) between China and Europe examine that there have strong the Revealed Comparative Advantage between China and Europe of all 20 different industries product.
Floral Specialization: what do floral attributes and floral visitors tell us?
Authors: Polatto Leandro Pereira , Alves-Junior Valter Vieira , Tavares Paulo Roberto de Abreu , de Morais Glaucia Almeida , Henrique Jessica Amaral , Netto José Chaud
Published: November 2022

Floral traits may either facilitate or constrain the gathering of food resources by certain animals. We therefore sought here to define the floral specialization levels of 19 plant species visited by foraging insects, based on their floral attributes and on the behaviors of their respective insect visitors. Based on those two criteria the degree of specialization of each plant-pollinator system was determined. The species studied had eight types of flowers (open, gullet, capitulum, opened with oil-secreting glands, opened with poricidal anthers, brush, tubular, and transition between open and deep polypetalous), and showed a continuum of pollination systems, from the more specialized levels to the most generalized. The most specialized species were visited predominantly by functional group of efficient pollinators, whereas the most generalist species received visitors of four or five functional groups, but they did not act as efficient pollinators. Furthermore, in the more generalist species it was not possible to characterize the floral visitors as pollen vectors or thieves/pillagers of resources. The parts of the insect bodies that transfer pollen to the floral stigmas can be grouped into five regions: the dorsal region of the thorax, the ventral region of the thorax and abdomen, the frontal region of the head, and the tibia and dorsal region of the abdomen. Plants evidencing even the highest levels of floral specialization can nonetheless be visited by floral resource thieves and/or robbers – indicating that floral specialization in itself is not capable of eliminating floral visitors prejudicial to plant reproduction.