bluuebunny/crossref_metadata_2025 huggingface dataset:
Inhalable Spray Dried Pro-Liposome Powder Containing Budesonide for Pulmonary Delivery
Authors: Kundawala Aliasgar J , Chauhan Khushbu S , Patel Harsha V , Kurtkoti Swati K
Published: July 2021

Budesonide is an anti-asthmatic agent which is used to control the symptoms of asthma like bronchospasm, oedema. Drug delivered to lung through inhalation will provide systemic and local drug delivery at lower dose in chronic and acute diseases. Dry powder inhalers are the best choice for targeting the anti-asthmatic drugs through pulmonary route. The objective of the present study is to prepare inhalable lipid coated budesonide microparticles by spray drying method so effective delivery of budesonide to the lungs can be achieved. The microparticles in the form of dry powder were obtained by either spray drying liposomal drug suspension or lipid drug suspension. The liposomes were initially prepared by solvent evaporation method using Hydrogenated Soyabean Phosphatidylcholine and Cholesterol (1:1, 1:2, 2:1) as lipid carrier and then spray dried later with mannitol as bulking agent at different lipid to diluent ratio (1:1.25, 1:2.5 & 1:5). The liposomes and liposomal dry powder were evaluated for vesicle size, % entrapment efficiency, in vitro drug release studies, powder characteristics, aerosol performance and stability studies. The liposomes prepared showed vesicle size (2-8 µm), Entrapment efficiency (92.22%) at lipid: drug ratio of (2.5:1) and observed 80.41 % drug release in 24 hrs. Pro-liposomes prepared by spray drying of liposomal drug suspension (LSD1) showed emitted dose, mean mass aerodynamic diameter, geometric standard deviation and fine particle fraction of 99.01%, 3.12 µm, 1.78 and 43.5% along with good powder properties. The spray dried powder was found to be stable at 4 ± 2 °C & 65% ± 5 % RH. The inhalable microparticles containing Budesonide containing lipid dry powder was successfully prepared by spray drying method that showed good aerodynamic properties and stability with mannitol as diluent. The microparticles produced with this novel approach could deliver drug on target via inhalation route and also ease manufacture process at large scale in fewer production steps.
Formulation and Evaluation of Salbutamol Sulphate Taste Masked Oral Disintegrating Tablets
Authors: Kumar Y.Shravan , M Karnakar , S Harika , M Mounika
Published: July 2021

Salbutamol is a short acting, selective beta2-adrenergic receptor agonist used in the treatment of astama and COPD. The aim of this study is to formulate oral disintegrating tablets of salbutamol sulphate to achieve rapid dissolution, absorption and further improving the bioavailability of the drug. Oral disintegrating tablets of salbutamol sulphate were designed with a view to enhance the patient compliance and provide a quick onset of action. The oral disintegrating tablets were prepared by using different synthetic polymers by direct compression method. Development of the formulation in the present study was based on the concentration of superdisintegrants and the properties of the drug. Nine batches of tablets were formulated and evaluated for various parameters: drug content, weight variation, water absorption ratio, wetting time, in vitro disintegration, hardness, friability, thickness uniformity, and in vitro dissolution. A fourier-transform infrared spectroscopy (FTIR) study showed that there were no significant interactions between the drug and the excipients. The prepared tablets were good in appearance and showed acceptable results for hardness and friability. The in vitro disintegrating time of the formulated tablets was found to be 14.39-32.41 sec and the drug content of tablets in all formulations was found to be between 87.48-99.96 %, which complied within the limits established in the Indian pharmacopeia. The study concluded that taste of the drug was masked with the help of sodium saccarhin, flavor and the concentration of super disintegrating agent increases the disintegration time of tablets get decreases. The formulation (F9) had a minimum disintegration time of 14.39 sec and 99.96 % of the drug was released within 20 min.
Angiotensin-(1-7) and Mas receptor in the brain
Authors: Rukavina Mikusic Natalia L. , Pineda Angélica M. , Gironacci Mariela M.
Published: July 2021

The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS has also been associated to the modulation of higher brain functions, including cognition, memory, depression and anxiety. For many years, angiotensin II (Ang II) has been considered the major bioactive component of the RAS. However, the existence of many other biologically active RAS components has currently been recognized, with similar, opposite, or distinct effects to those exerted by Ang II. Today, it is considered that the RAS is primarily constituted by two opposite arms. The pressor arm is composed by Ang II and the Ang II type 1 (AT1) receptor (AT1R), which mediates the vasoconstrictor, proliferative, hypertensive, oxidative and pro-inflammatory effects of the RAS. The depressor arm is mainly composed by Ang-(1-7), its Mas receptor (MasR) which mediates the depressor, vasodilatory, antiproliferative, antioxidant and anti-inflammatory effects of Ang-(1-7) and the AT2 receptor (AT2R), which opposes to the effects mediated by AT1R activation. Central Ang-(1-7) is implicated in the control of the cardiovascular function, thus participating in the regulation of blood pressure. Ang-(1-7) also exerts neuroprotective actions through MasR activation by opposing to the harmful effects of the Ang II/AT1R axis. This review is focused on the expression and regulation of the Ang-(1-7)/MasR axis in the brain, its main neuroprotective effects and the evidence regarding its involvement in the pathophysiology of several diseases at cardiovascular and neurological level.
2013 ir 2019 m. Lietuvos sveikatos mokslų universiteto ligoninės Kauno klinikose gimusių ir (arba) gydytų neišnešiotų (iki 30+6 savaitės) naujagimių mirštamumo ir komplikacijų palyginimas
Authors: Simanauskaitė Atėnė , Juotkutė Mantilė , Tamelienė Rasa
Published: July 2021

Tyrimo tikslas. Įvertinti ir palyginti 2013 ir 2019 m. Lietuvos sveikatos mokslų universiteto ligoninės Kauno klinikų (toliau – Kauno klinikų) Neonatologijos klinikoje gydytų neišnešiotų (iki 30+6 savaitės) naujagimių mirštamumą ir komplikacijas. Tyrimo metodai. Retrospektyviojo tyrimo metu analizuoti 109 2013 m. ir 1052019 m. neišnešiotų (iki 30+6 savaitės) naujagimių duomenys. Komplikacijos ir mirštamumas skirtingais metais įvertinti analizuojant medicininę dokumentaciją iš ligoninės archyvo. Rezultatai apdoroti ir susisteminti naudojantis „MO Excel“ ir „IBM SPSS Statistics 27.0“ programomis. Naudoti chi kvadrato (χ 2) ir t testai, rezultatai laikyti reikšmingais, kai p<0,05. Rezultatai. Mirštamumas 2013 m. siekė 11,93 proc. (n=13) ir 15,43 proc. (n=16), 2019 m. palyginus su 2013 m., reikšmingai didesnio svorio naujagimiai gimė 28–30+6 gestacinio amžiaus (GA) grupėje 2019 m. (p=0,042), jų Apgar po 1 (p=0,010) ir 5 (p=0,002) min. nuo gimimo analogiškai reikšmingai didesnis. 2019 m. neišnešioti naujagimiai vidutiniškai NITS praleido statistiškai daugiau laiko nei 2013 m. (p=0,036). Nustatyta, kad 2013 ir 2019 m. BPD (2013 m. p=0,001), sepsis (2019 m. p=0,011), ISK (2013 m. p=0,022), cPVL (2013 m. p=0,001) reikšmingai dažniau pasireiškė mažėjant GA. Išvados. Gerėjant diagnostikos ir gydymo galimybėms, stebimos geresnės ypač neišnešiotų naujagimių išgyvenamumo tendencijos, o bendras mirštamumas išlieka panašus – 11,93 proc. 2013 m. ir 15,43 proc. 2019 m. Daugeliu atvejų diagnozuojama viena arba daugiau neišnešiotiems naujagimiams būdingų komplikacijų. Nustatytas statistiškai reikšmingas ryšys tarp GA ir BPD, sepsio, ISK ir cPVL.
Vaisiaus kraujagyslių pirmeiga: prenatalinės diagnostikos svarba
Authors: Paškevičiūtė Elena , Ramašauskaitė Diana , Butkevičiūtė Augustė
Published: July 2021

Vaisiaus kraujagyslių pirmeiga (VKP) yra labai reta patologija, kurios nediagnozavus laiku, dėl didelės naujagimių hipoksijos ir nukraujavimo rizikos smarkiai sumažėja naujagimių išgyvenamumas. Prenatalinė VKP diagnozė ir tinkamai pasirinktas cezario pjūvio operacijos laikas yra būdas išvengti nepalankios nėštumo baigties. Šiuo metu nėra pakankamai aukšto lygio mokslinių įrodymų dėl virkštelės tvirtinimosi vietos nustatymo įtraukimo į standartinį ultragarsinio tyrimo protokolą. Straipsnyje pristatomas prenataliai nediagnozuotos VKP atvejis ir pateikiama literatūros apžvalga.
Vaisiaus galvos apimties sąsaja su cezario pjūvio operacija
Authors: Adomaitytė Milda , Merkevičius Kajus , Ulevičius Jonas
Published: July 2021

Tyrimo tikslas. Nustatyti galimas vaisiaus galvos apimties ir gimdymo baigčių sąsajas lietuvių gimdyvių  populiacijoje. Tyrimo metodai. Retrospektyvusis kohortinis tyrimas, atliktas Lietuvos sveikatos mokslų universiteto ligoninės Kauno klinikų (toliau – Kauno klinikos) Akušerijos ir ginekologijos klinikoje. Į tyrimą įtrauktos pirmą kartą gimdžiusios moterys (n=213), kurioms per septynias dienas iki gimdymo buvo atlikta vaisiaus fetometrija. Rezultatai. Vaisiaus galvos apimtis (VGA) koreliavo su cezario pjūvio operacija (CPO) dėl kliniškai siauro dubens (KSD) (rφ=0,235, p=0,001), tarp vaisiaus masės ir CPO ryšys nenustatytas. Nustatyti CPO dėl KSD rizikos veiksniai: rūkymas nėštumo laikotarpiu (ŠS 2,59; 95 proc. PI 1,05–6,45), užpakalinė pakaušio padėtis (UPP) (ŠS 19,27; 95 proc. PI 4,84–76,74), VGA≥338,8 mm (ŠS 5,98; 95 proc. PI 1,94–18,44). UPP, VGA≥338,8 mm, epidurinės analgezijos derinys turėjo 66,7 proc. teigiamą ir 91,8 proc. neigiamą prognostines vertes CPO dėl KSD. Išvados. Išmatuota 338,8 mm ir didesnė VGA bei užpakalinė vaisiaus galvos pakaušio padėtis gimdymo metu buvo siejamos su padidėjusia skubios CPO dėl KSD rizika.
A Comparative Study of the Words of Common Meanings In the Quran & Sunnah and their Effects on the Shariah Texts
Authors: Orakzai Syed Janan , Mubarak Shah
Published: July 2021

This research paper provides a general overview of the rationalization/interpretation of Shari’s texts in Islamic jurisprudence as words may have multiple meanings that has led to different interpretations between the Companions and later jurists. Therefore, the scholars feel the need to determine the appropriate meaning so they categorized the words into Nas, Muffaser, Muhkam, Mutashbih and Muawwal etc. The purpose of this categorization is to deduce a single definite meaning from these commonly used words. So the eminent researchers have discussed tawil, importance, conditions, various types and examples of retionlaziton in latter portions of the study.
The Impact of Media on Faith in our Contemporary Reality
Authors: Naseem  Shahdaa Ismail Yaseen
Published: July 2021

This research tackles media and its impact in the light of Quran and Sunnah. It explores the independence of Islamic media and its impact on Muslim faith. It, also reveals the bad pictures that offend Islam and its values through focusing on the objectives of contemporary media channels. The research suggests some treatment and solutions to the problem.

Allah is the Arbiter of Success
HISTORICAL APPROACH TO RE-EXAMINATION OF TECHNICAL EQUIPMENT FOR RESCUE FROM HEIGHT IN FIRE SERVICE UNITS
Authors: Вищекин Максим Вадимович , Дымов Сергей Михайлович , Русанов Дмитрий Юрьевич , Александров Александр Михайлович
Published: July 2021

В статье рассмотрена историческая перспектива изменения нормативного подхода к периодическому освидетельствованию средств спасения с высоты. Глубина обзора не превышает 37 лет. Область обзора ограничена ведомственной принадлежностью к пожарной охране.

The article discusses the historical perspective of changing the normative approach to periodic inspection of equipment for rescue from height. The depth of survey does not exceed 37 years. The scope of survey is limited by the departmental affiliation to fire service.
DIRECTIONS OF EXPERIMENTAL RESEARCH ON THE USE OF UNMANNED AIRCRAFT SYSTEMS FOR FIRE EXTINGUISHING IN HIGH-RISE BUILDINGS USING COMPRESSION FOAM
Authors: Лопухов Алексей Анатольевич , Логинов Владимир Иванович , Осипов Юрий Николаевич , Ершов Владимир Иванович
Published: July 2021

Статья посвящена решению проблем применения беспилотных авиационных систем для тушения пожаров в зданиях повышенной этажности с непрерывной подачей к очагу пожара компрессионной пены. Актуальность материалов статьи обусловлена тем, что, с одной стороны, одним из перспективных способов тушения пожаров в высотных зданиях в инженерных кругах признано использование компрессионной пены с непрерывной подачей от наземного источника с помощью беспилотных авиационных судов, а с другой стороны, тем, что данный вопрос недостаточно изучен. В статье представлены результаты исследований по данной тематике, выполненных МЧС Республики Беларусь и МЧС России, предложены отдельные направления дальнейших экспериментальных исследований и требования, которые должны предъявляться к пожарным беспилотникам.

The article is devoted to the problems of using unmanned aircraft systems to extinguish fires in high-rise buildings with continuous supply of compression foam to the fire source. On the one hand, the use of compression foam with a continuous flow from ground source by unmanned aircraft is considered as one of the most promising ways of fighting fires in high-rise buildings. On the other hand the relevance of the article is due to the fact of insufficient study of aforesaid issue. The article presents the results of research on the subject, implemented by the Ministry of emergency situations of the Republic of Belarus and EMERCOM of Russia. There were proposed some directions for further experimental investigations as well as the requirements for fire drones.
Análisis Sensorial como una Herramienta Clave para Innovar en la Industria Vinícola
Authors: Peña González María Alicia , Peña González Silvia , García Zumalacarregui Jorge
Published: July 2021

La innovación y desarrollo de productos dentro de la industria alimentaria resulta clave para lograr la supervivencia de las empresas, no obstante, estos procesos requieren ser sometidos a actividades de validación que permitan disminuir el riesgo de fracaso de nuevos alimentos en el mercado. En este contexto, el análisis sensorial resulta una herramienta importante para medir el grado de aceptabilidad en los consumidores de un producto alimenticio. La presente investigación evalúa las características sensoriales de tres tipos de productos vinícolas, sometidos a un proceso de microfiltración frente a sus similares pasteurizados, con el objetivo de establecer criterios de control de calidad y grado de aceptación del mercado. Para este desarrollo, se validaron los jueces sensoriales de la empresa vinícola y, posteriormente, se aplicaron pruebas discriminativas y descriptivas sensoriales a las muestras en estudio. Adicionalmente, se realizaron controles microbiológicos y de turbidez. A partir de los resultados obtenidos, se puede observar que hubo diferencias para los atributos: intensidad olfativa e intensidad gustativa en el vino tinto; no obstante, en los demás parámetros sensoriales analizados, no se evidenciaron diferencias significativas entre las muestras analizadas. Para el caso de las bebidas elaboradas a base de vino tinto y vino blanco, no se reportaron diferencias en ninguno de los atributos sensoriales. Los resultados microbiológicos y turbidez se mantuvieron dentro de los rangos establecidos en todas las muestras. Por lo antes expuesto, se puede concluir que, al mantener las características organolépticas en el producto, la innovación realizada resulta satisfactoria al mejorar su eficiencia y mantener el grado de aceptabilidad de sus potenciales consumidores.
Percepción de los Roles de Pareja en lo Laboral y Doméstico como Resultante de la Diferencia de Género
Authors: Fernández Solís Carla , Solís Gloria de Lourdes , Fernández Ronquillo Mario
Published: July 2021

Los roles de pareja, tanto en el área laboral como en la doméstica, son el resultado de la diferencia de género, y, en la actualidad, generan interés mundial debido a que esta diferenciación ha provocado un fenómeno discriminatorio y violencia de género en contra de la mujer. El propósito de este estudio consiste en realizar una revisión de literatura sobre estos temas y presentar los resultados de una investigación descriptiva que se llevó a cabo sobre los rasgos característicos de la relación entre parejas, como roles que desempeñan, actividades de mayor desenvolvimiento, cualidades y defectos y comportamientos en el ámbito laboral; y, con base en este análisis, se establecen recomendaciones que tiendan a disminuir los niveles de diferencia de género y dejan abiertas alternativas para investigaciones futuras.
FINANÇAS PÚBLICAS: UM ESTUDO DA PERFORMANCE ORÇAMENTÁRIA DO MUNICÍPIO DE SARANDI - PARANÁ
Authors: Ribeiro Roberto Rivelino Martins , Abreu Sueli Miranda de , Borges Iasmini Magnes Turci , Mattiello Kerla , Soares Augusto Cesare de Campos
Published: July 2021

A proposta desta pesquisa se deu no contexto de transparência e controle social nas contas públicas e o desempenho das finanças municipais, nesse sentido, se estabeleceu como objetivo investigar os relatórios resumidos de execução orçamentária disponibilizados no Tribunal de Contas do Paraná, do município de Sarandi, no período de 2013 a 2108. A base teórica da pesquisa pautou-se na apreciação das finanças públicas na perspectiva da contabilidade governamental, no orçamento público e na lei de responsabilidade fiscal; já os procedimentos metodológicos, em termos de objetivos são de pesquisa descritiva, com procedimentos técnicos de pesquisa bibliográfica e documental, de natureza aplicada, abordagem qualitativa e quantitativa, e, ambiente de campo; com relação à coleta de dados se deu em forma de dados primários obtidos do sítio eletrônico do TCE e com análise documental. Os resultados encontrados demonstram que houve uma elevação na arrecadação no período; as receitas correntes tiveram um crescimento de aproximadamente 74%; as receitas de capital tiveram elevação constante; destaca-se que no ano de 2016 o crescimento foi o mais expressivo do período da pesquisa. Nas despesas a pesquisa evidenciou que, seja nas despesas corrente ou capital, não houve liquidação em sua totalidade, o que se entende como certa ingerência; em 2017 se verificou o pior desempenho, pois se deixou de quitar quase 22% das despesas. Por fim, constatou-se que de fato os relatórios orçamentários evidenciaram a capacidade de captação de recursos, porém, demonstrou também, um desempenho de falha no tocante à liquidação das despesas.
OS CLUBES DO FUTEBOL BRASILEIRO DURANTE A PANDEMIA DO NOVO CORONAVÍRUS
Authors: Reis Antonio Ribas , Campos Maria de Fátima Hanaque , Lopes Jerisnaldo Matos
Published: July 2021

No início da segunda quinzena do mês de março de 2020, as competições de futebol no Brasil foram suspensas por tempo indeterminado, em virtude do isolamento social, consequência da pandemia do novo coronavírus. O objetivo deste estudo foi relatar algumas ações do Esporte Clube Bahia, no início da suspensão das atividades a 17 de maio 2020. Considerando o objetivo estabelecido, foi realizada uma pesquisa exploratória visando proporcionar maior proximidade com o tema e torná-lo mais compreensível, envolvendo levantamento bibliográfico e análise de exemplos estimulando a compreensão, classificadas como: pesquisa bibliográfica e estudo de caso. E, também, a pesquisa descritiva, um tipo de estudo que visa descrever os fatos e os fenômenos de determinada realidade, por meio da pesquisa documental e da pesquisa ex-post-facto. Verificou-se que o Esporte Clube Bahia promoveu ações relevantes, tais como: empréstimo do centro de treinamento ao Governo do Estado para dar suporte à rede de saúde da Bahia; a construção do monumento “Juntos Venceremos!”; a ação concedendo descontos das mensalidades dos sócios com o slogan “não queremos te perder”. A pesquisa demonstrou como um clube de futebol do nordeste brasileiro está conseguindo lidar com um cenário que trouxe consequências significativas nas receitas do clube.
COMPETÊNCIAS E HABILIDADES NECESSÁRIAS AO
LÍDER/GERENTE DE PROJETOS DE SUCESSO
Authors: Balaban Dayane Gomes Barros
Published: July 2021

Este artigo tem como objetivo identificar, quais são as competências e habilidades necessáriaspara gerenciar projetos de sucesso, aspectos necessários ao gerente de projetos. Descrevehabilidades e competências para que um profissional se torne um bom gerente de projetos.Relata como essas características interagem com o aprendizado das áreas de conhecimento,ferramentas e técnicas de gestão. Relaciona a atual situação socioeconômica do Brasil com aexigência do mercado atual de trabalho na área de projetos.
CLASSIFICAÇÃO DE DOCUMENTOS DE PATENTES USANDO O DOC2VEC
Authors: Mascarenhas Tamara Aguiar Tavares , Mascarenhas Alberto Willian , Bonfante Andreia Gentil
Published: July 2021

As patentes são consideradas fontes extremamente úteis para atividades relacionadas à busca e análise de informações e para a geração de novos conhecimentos. Neste artigo, usamos um algoritmo de vetor de parágrafo doc2vec, uma extensão do word2vec, que aprende representações de frases em um documento, em um esquema de aprendizagem profunda supervisionada para a classificação automática de patentes. A classificação foi realizada em documentos com resumos de patentes em inglês, em um processo hierárquico que compreende seções, classes, subclasses, de acordo com a Classificação Internacional de Patentes (IPC). Os testes foram desenvolvidos em quatro etapas, necessária, devido ao grande número de classes e subclasses, com o objetivo de identificar códigos IPC primário ou secundários, caso esteja associado a um conjunto de classificações relacionadas a outros aspectos expressos na patente. Os testes apresentaram resultados bastante promissores na classificação de patentes. Os próximos passos serão produzir avaliações qualitativas e compará-las com outros modelos de aprendizagem de máquina presentes na literatura.
ESTRATÉGIAS SUSTENTÁVEIS: UM ESTUDO DE CASO SOBRE PRODUÇÃO E COMERCIALIZAÇÃO DE MORANGOS ORGÂNICOS NO CURIMATAÚ PARAIBANO
Authors: Duarte Sibele Thaise Viana Guimarães , Castro Marizângela Lima dos Santos
Published: July 2021

O presente estudo visa analisar as estratégias e as práticas de responsabilidade ambiental do Hortifrúti Canteiro Cheiro Verde. Empresa situada no município de Nova Floresta-PB, no curimataú paraibano, referência regional em inovação e produção sustentável. O negócio já atua há mais de 15 anos no setor de hortifrutigranjeiros, empregando técnicas agroecológicas de produção e aclimatização em viveiros, com o intuito de produzir frutas e vegetais da melhor qualidade, sem agroquímicos. O principal objetivo desse estudo foi identificar as estratégias utilizadas pela empresa Canteiro Cheiro Verde, levando em consideração aspectos socioambientais, além de tentar mensurar as oportunidades de crescimento do negócio a partir da elaboração de um planejamento estratégico, após a introdução da produção de morangos semi-hidropônicos, no mercado local. O trabalho realizado apresenta-se como sendo um estudo de caso, utilizando-se como técnicas de pesquisa a observação participante, entrevistas semi-estruturadas, levantamentos bibliográficos e documental, logo, sua natureza classifica-se como exploratória, qualitativa. Como resultados pôde-se identificar as principais oportunidades e ameaças, e forças e fraquezas da empresa a partir da introdução da cultura dos morangos semi-hidropônicos no negócio. O estudo colaborou com a identificação das falhas estratégicas da organização e ainda pode contribuir na elaboração de ações corretivas, a fim de garantir um melhor posicionamento da empresa diante dos clientes, colaboradores e fornecedores.
O CONTROLE INTERNO NAS MICROEMPRESAS E EMPRESAS DE PEQUENO PORTE
Authors: Nascimento João Paulo Silva do , Gomes Douglas Willyam Rodrigues , Oliveira Oderlene Vieira de
Published: July 2021

O presente artigo tem como objetivo geral apresentar o controle interno como ferramenta de desenvolvimento as microempresas e empresas de pequeno porte, buscando a tomada de decisão mais eficaz. O referencial teórico foi embasado na literatura de autores Almeida (2010), Attie (2010), Crepaldi (2007), Godoy (1998), Oliveira (2001), Silva Júnior (2001) e dentre outros, na qual abordam conceitos pertinentes as ferramentas de controle interno. Metodologicamente foi realizada uma pesquisa descritiva, aplicando uma abordagem do problema de forma qualitativa. A coleta e análise dos dados tiveram como fundamento a aplicação de um questionário dicotômico aberto a justificativas com proprietários ou gerentes das microempresas e empresas de pequeno porte. As empresas abordadas estão situadas em um município do Sertão Central do Ceará. Como resultados destaca-se a apresentação do percentual de empresas que utilizam as ferramentas do controle interno, uma vez que oferece vantagens à gestão empresarial, desde que seja aplicado e monitorado de forma adequada, auxiliando os gestores a proteger seus ativos através de informações exatas, confiáveis e oportunas, buscando prevenir erros, fraudes e atos ilícitos. Conclui-se que o controle interno é parte integral na execução do processo administrativo, sendo responsável pela criação de padrões e medição de desempenho. Ademais oportuniza os instrumentos de crescimento, desenvolvimento, rentabilidade e confiança no mercado para uma gestão empreendedora eficiente e eficaz.
DEVELOPING AN INTEGRATED MODEL FOR EVALUATING R&D ORGANIZATIONS’ PERFORMANCE: COMBINATION OF DEA-ANP
Authors: Hoseini Seyed Amirali , Fallahpour Alireza , Wong Kuan Yew , Antuchevičienė Jurgita
Published: July 2021

Assessing the performance of the Research and development (R&D) organizations to achieve higher productivity, growth, and development is always a critical necessity.
Therefore, developing a more accurate model to evaluate the performance is always required. For this purpose, this study is aimed at developing a decision-making model for evaluating R&D
performance. The model comes up with determining the most proper evaluative criteria for assessing R&D organizations. Then, it integrates Data Envelopment Analysis (DEA) with Analytical
Network Process (ANP) to assess R&D performance. This paper is aimed to develop an integrated model for evaluating R&D performance. The findings of the study show that the DEA-ANP
model is an accurate and acceptable model for evaluating R&D organizations’ performance.
The California Legacy Survey. I. A Catalog of 178 Planets from Precision Radial Velocity Monitoring of 719 Nearby Stars over Three Decades
Authors: Rosenthal Lee J. , Fulton Benjamin J. , Hirsch Lea A. , Isaacson Howard T. , Howard Andrew W. , Dedrick Cayla M. , Sherstyuk Ilya A. , Blunt Sarah C. , Petigura Erik A. , Knutson Heather A. , Behmard Aida , Chontos Ashley , Crepp Justin R. , Crossfield Ian J. M. , Dalba Paul A. , Fischer Debra A. , Henry Gregory W. , Kane Stephen R. , Kosiarek Molly , Marcy Geoffrey W. , Rubenzahl Ryan A. , Weiss Lauren M. , Wright Jason T.
Published: July 2021

We present a high-precision radial velocity (RV) survey of 719 FGKM stars, which host 164 known exoplanets and 14 newly discovered or revised exoplanets and substellar companions. This catalog updated the orbital parameters of known exoplanets and long-period candidates, some of which have decades-longer observational baselines than they did upon initial detection. The newly discovered exoplanets range from warm sub-Neptunes and super-Earths to cold gas giants. We present the catalog sample selection criteria, as well as over 100,000 RV measurements, which come from the Keck-HIRES, APF-Levy, and Lick-Hamilton spectrographs. We introduce the new RV search pipeline RVSearch (https://california-planet-search.github.io/rvsearch/) that we used to generate our planet catalog, and we make it available to the public as an open-source Python package. This paper is the first study in a planned series that will measure exoplanet occurrence rates and compare exoplanet populations, including studies of giant planet occurrence beyond the water ice line, and eccentricity distributions to explore giant planet formation pathways. We have made public all radial velocities and associated data that we use in this catalog.
Prognostic Indices of Surgical Outcome in Cervical Spondylotic Myelopathy: A Clinical Prospective Study
Authors: Marei Ahmed A. , Rady Mohamed Reda , Kamal Hazem Mostafa , Welch William C. , Hafez Mohamed A.
Published: July 2021

BACKGROUND: One of the most common causes of spinal cord dysfunction is cervical spondylotic myelopathy (CSM) especially in the elderly. Prognostic indices can aid the surgeon preoperatively to detect the patients’ prognosis.

AIM: The aim of the work is to better assess patients and to find possible indicators for post-operative improvement or deterioration in CSM patients.

METHODS: Forty patients with multiple levels CSM, admitted and operated on in the Neurosurgery Department of Cairo University Hospitals, have been enrolled randomly in this study after fulfilling the criteria for CSM surgical intervention. The patient age, complaint duration, number of levels affected, signal intensity on T1-weighted and T2-weighted magnetic resonance (MR) images, Japan Orthopedic Association (JOA) scoring system, and Nurick’s score were evaluated before surgery and correlated with outcome after 1 year follow-up.

RESULTS: About 80% of patients improved after operation with average pre- and post-operative JOA and Nurick scores about 11.23 and 3.12; 14.1 and 1.6, respectively. Patient age, sex, number of levels affected, and signal intensity on T1- weighted and T2-weighted MR images were not significantly associated with post-operative improvement, p > 0.05. However, the only significant prognostic factor was the duration of symptoms if less than 1 year with p < 0.05.

CONCLUSION: Short complaint duration coupled with close intra-operative monitoring was directly correlated with good CMS operation outcome while age, sex, number of levels affected, presence of cord signal on MR imaging, and surgical approach appear to have no significant effect on outcome.
The New Detection Method of Ovarian Follicle Development Using Digitized Wide Area Measurement
Authors: Noviyanti Noviyanti , Yueniwati Yuyun , Rahardjo Bambang , Mintaroem Karyono , Khristian Erick
Published: July 2021

METHODS: The research method used in this research was experimental laboratory with pre-and posttest only control group design.

RESULTS: The result shows that the extradiol level which has range of 26.30–31.03 from 28 experimental animals measured, this showed more measurement diameter which has not had measurement addition compare with the wide percentage of measurement. The result shows strong correlation between digitalized measured wide follicles to the changing of estradiol level with value of 0.453. The result of comparation between estradiol level and measured diameter shows weak correlation. This shows that manual measurement of follicle diameter still weak to the changing of estradiol level.

CONCLUSION: There is strong correlation between measured wide area follicle used ImageJ applications to the changing of estradiol level compare to the measurement of follicle diameter.
Аllergic Basal Deciduitis as a Reason of Recurrent Antenatal Fetal Death
Authors: Kamyshanskiy Yevgeniy , Kostyleva Olga , Tussupbekova Maida , Stabayeva Leila , Imanbayeva Gulnazira , Nygyzbayeva Raihan , Kotov Evgeniy , Kossitsyn Denis
Published: July 2021

BACKGROUND: Allergic diseases of pregnant women are associated with chronic placental insufficiency and the development of immunopathological conditions of unknown etiology in a child in postnatal life. Pregnancy with bronchial asthma is often complicated by intrauterine growth retardation, preeclampsia, and antenatal fetal death. AIM: The objective was to present a clinical case of recurrent antenatal fetal death in the third trimester in women with bronchial asthma under controlled course. CASE REPORT: Pregnancy proceeded without clinical signs of exacerbation of bronchial asthma and allergic status. However, chronic inflammation with eosinophilia in the intervillous space and the basal lamina was revealed in the placenta tissue. Eosinophilia of the intervillous area was accompanied by obliteration of the intervillous area by fibrin deposits. CONCLUSION: We suppose that immunological inflammation at the fetoplacental unit level can occur regardless of the mother’s allergic status. Moreover, it is likely that the objective state of the mother in the presence of an allergic disease does not reflect the presence/absence of an immunological process in the placenta, as the immunological inflammatory process can develop in different compartments (at the level of the mother’s body and the placental-fetal compartment) with varying degrees of severity.
Mesenteric Cystic Lymphangioma in Pediatric Patient: A Rare Intra-Abdominal Tumor Management in Rural Country Case Report
Authors: Kusuma Perdhana , Putra Muhammad David Perdana , Suwardi Suwardi
Published: July 2021

Introduction: Mesenteric Cystic Lymphangioma (MCL) is a benign malformation of the lymphatic system. MCL seldomly occurs with a very rare incidence of around 1: 250,000. This neoplasm is more common in pediatric patients. Symptoms can appear with various clinical features ranging from asymptomatic abdominal mass to acute abdomen.
Case description: Here we report a patient with MCL: that presented with bilious vomiting, abdominal pain, and abdominal mass. The patient underwent explorative laparotomy, mass excision, and  jejunal resection.
Discussion: Although benign, MCL can cause other symptoms such as bleeding, torsion, or lymphangioma rupture. Therefore, MCL should be considered as one of the differential diagnoses in acute abdominal and abdominal mass cases in children.
Conclusion: In conclusion, although sometimes asymptomatic and found incidentally, the MCL should be resected because it has the potential to grow and invade vital organs and cause life-threatening complications.
Cutaneous B-Cell Pseudolymphoma Successfully Treated with Triamcinolone Acetonide
Authors: Anggraeni Tulus Dyah , Nurdin Airin , Tabri Farida , Ilyas Faridha
Published: July 2021

BACKGROUND: Cutaneous pseudolymphoma (PSL) is a reactive polyclonal benign lymphoproliferative process in the skin that simulate cutaneous lymphomas clinically, histologically, or both, predominantly composed of either B-cells or T-cells, localized or disseminated. PSL clinically manifests as solitary nodules or plaque on the face. In cases where cutaneous PSL is suspected, the most crucial part is diagnosis, to differentiate benign or malignant lesion. Diagnosis required a combination of clinical, histopathological, and immunohistochemistry examination.

CASE REPORT: A 59-year-old man presented with asymptomatic erythematous plaque on her cheek for 6 months before. Histopathological examination revealed dense small lymphocytic infiltration forming lymphoid follicles with centrum germinativum that partially destructed skin appendice glands. Immunohistochemistry examination showed positive result on cluster of differentiation (CD)20 and CD3 staining. With domination of CD20 treatment: Patient was treated with intralesional injection of triamcinolone acetonide 10 mg/ml and showed satisfying result after 3 times injection.

CONCLUSION: A cutaneous B-cell PSL in a 59-year-old man was diagnosed based on history and physical, histopathological, and also immunohistochemistry examination. Intralesional injection of 10 mg/ml triamcinolone acetonide gave satisfying result.
Clinical Profiles, Demographic Features, and Maternal Outcomes among Coronavirus Disease Positive Pregnant Women: A Cross-sectional Study
Authors: Saadia Zaheera , Farrukh Robina , Kanwal Sumaira , Shahzad Quratulain
Published: July 2021

BACKGROUND: Pregnant women are susceptible to coronavirus infection due to physiological changes in the circulatory and immunological parameters. AIM: The current study aimed to determine the demographic factors, clinical symptoms, and fetal-maternal outcomes and also compare the blood parameters and chest X-ray results among coronavirus disease 2019 (COVID-19) positive and negative pregnant women. MATERIALS AND METHODS: Complete blood count and Chest X-rays were performed as a routine in all pregnant women. Polymerase chain reaction for COVID-19 was performed for all women and the newborn. RESULTS: The blood parameters revealed that a significantly greater proportion of COVID-19 positive pregnant women had abnormal hemoglobin, total leukocyte count, neutrophil count, lymphocyte count, monocyte count, bilirubin, aspartate aminotransferase, alanine aminotransferase, and urea. CONCLUSIONS: The present study provided crucial insights into epidemiological and clinical features during the perinatal period. Chest X-rays and blood routine examination are reliable findings to prevent COVID-19 complications among pregnant women.
Epidemiology and Treatment of Peripheral Neuropathy in Systemic Sclerosis
Authors: AlMehmadi Bader A. , To Fergus Z. , Anderson Melanie A. , Johnson Sindhu R.
Published: July 2021

Objective

The epidemiology and treatment of peripheral neuropathy in systemic sclerosis (SSc) is poorly understood. The objectives of this study were to evaluate the incidence, prevalence, risk factors, and treatments of peripheral neuropathy in SSc.

Methods

A systematic review of MEDLINE, Embase, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases for literature reporting peripheral neuropathy in SSc was performed. Studies evaluating incidence, prevalence, risk factors, and treatments were synthesized. A metaanalysis using a random effects model was used to evaluate the prevalence of peripheral neuropathy.

Results

This systematic review identified 113 studies that reported 949 of 2143 subjects with at least 1 type of peripheral neuropathy. The mean age was 48.5 years. The mean time between SSc onset and detection of peripheral neuropathy was 8.85 years. The pooled prevalence of neuropathy was 27.37% (95% CI 22.35–32.70). Risk factors for peripheral neuropathy in SSc included advanced diffuse disease, anticentromere antibodies, calcinosis cutis, ischemia of the vasa nervorum, iron deficiency anemia, metoclopramide, pembrolizumab, silicosis, and uremia. There were 73 subjects with successful treatments (n = 36 restoring sensation, n = 37 restoring motor or sensorimotor function). Treatments included decompression surgery, prednisone, cyclophosphamide, carbamazepine, transcutaneous electrical nerve stimulation, tricyclic antidepressants, and intravenous Ig.

Conclusion

All-cause peripheral neuropathy is not uncommon in SSc. Compression neuropathies can be treated with decompression surgery. Observational data reporting immunosuppressives and anticonvulsants to treat peripheral neuropathy in SSc are limited and conflicting. Randomized controlled trials are needed to evaluate the efficacy of these interventions.
Facing disinformation: Five methods to counter conspiracy theories amid the Covid-19 pandemic
Authors: Guan Tianru , Liu Tianyang , Yuan Randong
Published: July 2021

Among the burgeoning discussions on the argumentative styles of conspiracy theories and the related cognitive processes of their audiences, research thus far is limited in regard to developing methods and strategies that could effectively debunk conspiracy theories and reduce the harmful influences of conspiracist media exposure. The present study critically evaluates the effectiveness of five approaches to reducing conspiratorial belief, through experiments (N=607) conducted on Amazon Mechanical Turk. Our results demonstrate that the content-based methods of counter conspiracy theory can partly mitigate conspiratorial belief. Specifically, the science- and fact-focused corrections were able to effectively mitigate conspiracy beliefs, whereas media literacy and inoculation strategies did not produce significant change. More crucially, our findings illustrate that both audience-focused methods, which involve decoding the myth of conspiracy theory and re-imagining intergroup relationships, were effective in reducing the cognitive acceptance of conspiracy theory. Building on these insights, this study contributes to a systematic examination of different epistemic means to influence (or not) conspiracy beliefs -an urgent task in the face of the infodemic threat apparent both during and after the COVID-19 pandemic.

Entre las crecientes discusiones sobre los estilos argumentativos de las teorías de conspiración y los procesos cognitivos relacionados de su público, los estudios hasta ahora son limitados en lo que respecta al desarrollo de métodos y estrategias que podrían desacreditar eficazmente las teorías de conspiración y reducir las influencias dañinas de la exposición a los medios de comunicación conspirativos. El presente estudio evalúa de manera crítica la efectividad de cinco enfoques para reducir la creencia en conspiraciones, a través de experimentos (N=607) realizados en Amazon Mechanical Turk. Nuestros resultados demuestran que los métodos basados en el contenido al enfrentar las teorías de la conspiración pueden mitigar parcialmente la creencia conspiratoria. Específicamente, las correcciones centradas en la ciencia y los hechos fueron capaces de mitigar eficazmente las creencias en la conspiración, mientras que las estrategias de alfabetización mediática e inoculación no produjeron cambios significativos. Más importante aún, nuestros hallazgos ilustran que ambos métodos centrados en el público, que implican decodificar el mito de la teoría de la conspiración y reimaginar las relaciones intergrupales, fueron efectivos para reducir la aceptación cognitiva de la teoría de la conspiración. Basado en estos conocimientos, este estudio contribuye a un examen sistemático de distintos medios epistemológicos para influir (o no) en las creencias conspirativas, una tarea urgente frente a la evidente amenaza infodémica, tanto durante como después de la pandemia de COVID-19.
À la Confédération paysanne, des paysans écologistes… mais pas végans
Authors: Martin Jean-Philippe
Published: July 2021

Depuis les années 1980, des paysans expérimentateurs refusent le productivisme, veulent lutter contre la pollution et fournir des produits de qualité. La Confédération paysanne a largement contribué, à la prise en compte des préoccupations écologiques par le monde paysan. Quelles sont les idées et les pratiques diffusées par ces paysans écologistes ? Les paysans écologistes sont de nos jours confrontés à de nouvelles questions qui débouchent sur des tensions avec des écologistes des villes. Est-il possible de créer des espaces « naturels » sauvages inaccessibles aux paysans ou aux éleveurs et à leurs bêtes ? Doit-on laisser les loups croquer les agneaux sans que les bergers interviennent ? Peut-on domestiquer des animaux ? La viande d’origine animale peut-elle être consommée ? Le syndicat essaie de maintenir le dialogue mais entend répondre à ces questions en défendant le point de vue des paysans et des éleveurs et en présentant leurs pratiques.
État de santé, estime de soi et facteurs associés chez les sujets âgés de la Province d’Essaouira, Maroc
Authors: Ouzennou Nadia , Manoussi Abdelmounaim , Mejdouli Hicham , Abssane Fatim-Ezzahra , Chakir Oumaima , Ed-Dokkali Fatima , Amor Hakima , Baali Abdellatif
Published: July 2021

L’objectif de cette recherche était d’explorer l’état de santé des personnes âgées et les facteurs qui lui sont associés, dans un contexte de précarité, dans la province d’Essaouira. Une enquête par entrevue structurée a été menée auprès de 739 sujets âgés qui ont répondu aux questions renseignant sur leurs conditions de vie et leur état de santé exprimé par l’état de santé subjective et l’estime de soi. Les résultats ont montré que 75,5 % des sujets âgés se percevaient en bonne santé même si la majorité d’entre eux, soit 59 %, avaient des pathologies. De même, la valeur moyenne de l’estime de soi était de 29,02, qualifiant ce groupe à faible estime de soi. Les résultats ont également montré que l’estime de soi était significativement associée à certains critères, notamment : l’origine rurale, l’âge de plus de 70 ans, l’analphabétisme, le niveau socio-économique bas, et à la perception de l’état de santé générale. Au Maroc, bien qu’il ait réussi relativement à améliorer les conditions sanitaires et économiques de la population en général, les conditions socio-économiques et psychologiques des personnes âgées restent toutefois précaires.
Étude de la qualité de vie et des pathologies associées chez les personnes âgées de la province d’El Jadida
Authors: Ahaji Azzelarab , Mziwira Mohamed , Naciri Kaoutar , Belahsen Rekia
Published: July 2021

Au Maroc, la proportion de personnes âgées est en augmentation, ce qui entraîne de multiples implications sociales, économiques et culturelles. Ce travail de recherche est entrepris dans le but d’analyser les caractéristiques médicales et socio-économiques liées à l’état de santé et à la qualité de vie de la population âgée de la région d’El Jadida au Maroc. Il s’agit d’une étude transversale conduite sur un échantillon aléatoire de 537 personnes, âgées de 60 ans et plus, dont 63,5 % sont en retraite et 27 % analphabètes et qui ont visité les centres de santé publique de la province d’El Jadida dans le nord-ouest du Maroc. En termes de qualité de vie, seulement 8,8 % se perçoivent en bon état de santé, alors qu’un quart de la population souffre d’insomnie et d’anxiété. Dans les dimensions médicales, les maladies chroniques les plus diagnostiquées sont l’hypertension, l’obésité et le diabète. Cette population souffre aussi de déficiences visuelles, de problèmes d’audition et bucco-dentaires malgré que les données sur l’accès aux services de santé montrent que la couverture médicale touche 70,4 %. Ces résultats suggèrent un besoin urgent de mettre en œuvre une politique médicale concernant cette catégorie de population afin d’assurer une prise en charge totale.
Le divorce et l’argent des hommes. Perceptions et conséquences sur les arrangements financiers entre adultes et avec les enfants
Authors: Henchoz Caroline
Published: July 2021

Dans les recherches sur les organisations financières des ménages, l’argent masculin est souvent présenté comme un argent préservé, un argent puissant car associé à du pouvoir et à un certain nombre de privilèges. L’image qui en est donnée lors d’un divorce est tout autre. S’appuyant sur une quarantaine d’entretiens réalisés auprès d’hommes, de femmes et d’enfants de couples divorcés, cet article tente d’expliquer d’où vient la représentation largement partagée par les acteurs et actrices du divorce du père financièrement perdant et d’un argent masculin menacé par la séparation. Il montre que cette représentation a valeur de prophétie autoréalisatrice, car elle a des conséquences sur les arrangements financiers qui se mettent en place entre les femmes et les hommes mais aussi avec les enfants suite à une séparation. Ces échanges familiaux post-rupture vont contribuer à renforcer le prestige symbolique de l’argent masculin et à invisibiliser les contributions féminines et enfantines confortant la perception qu’à l’argent masculin généreux répond l’argent immérité des femmes et des enfants.