bluuebunny/crossref_metadata_2025 huggingface dataset:
Delamination Prediction in Layered Composites Using Optimized ANN Algorithms: A Comparative Analysis
Authors: Balkan Demet
Published: January 2025

This study investigates the effectiveness of Artificial Neural Networks (ANNs) in predicting the outcomes of Double Cantilever Beam (DCB) tests, focusing on time and force as input variables and displacement as the predicted output. Three ANN training algorithms—Scaled Conjugate Gradient (SCG), Broyden Fletcher Goldfarb Shanno (BFGS) Quasi-Newton, and Levenberg-Marquardt (LM)—were evaluated based on prediction accuracy and computational efficiency. A parametric study was performed by varying the number of neurons (from 10 to 100) in a single hidden layer to optimize network structure. Among the evaluated algorithms, LM demonstrated superior performance, achieving prediction accuracies of 99.6% for force and 99.3% for displacement. In contrast, SCG exhibited the fastest convergence but had a significantly higher error rate of 8.6%. The BFGS algorithm provided a compromise between accuracy and speed but was ultimately outperformed by LM in terms of overall precision. In addition, configurations with up to 100 neurons were tested, indicating that although slightly lower error rates could be achieved, the increase in computation time was substantial. Consequently, the LM algorithm with 50 neurons delivered the best balance between accuracy and computational cost. These findings underscore the potential of ANNs, particularly LM-based models, to enhance material design processes by providing reliable predictions from limited experimental data, thereby reducing both resource utilization and the time required for testing.
Implementing Computer Vision in Android Apps and Presenting the Background Technology with Mathematical Demonstrations
Authors: Szabo Roland
Published: January 2025

The aim of this paper is to create image-processing Android apps to launch on the Google Play Store. Three apps with different usages will be presented for different situations. The first app is a night-vision app on an Android phone that uses OpenCV. The second app is a tooth-brushing assistant application. The app is made for mobile phones and uses advanced image-processing techniques to detect when the tooth is brushed correctly or incorrectly. The main focus is on the direction of the toothbrush movement because this is one of the key aspects of correctly brushing teeth. The direction of movement of the brush is detected using movement vectors. The third app is a lane-detection app on the smartphone. Lane detection is carried out using OpenCV and TensorFlow libraries. The mobile app was implemented on the Android operating system. The app has a live video feed of the surroundings. When in the area of view, there will be a road with a lane. The system detects the lane and draws a green line over it.
A Scenario for Origin of Global 4 mHz Oscillations in Solar Corona
Authors: Xue Li , Jiao Chengliang , Zhang Lixin
Published: January 2025

We establish a spherically symmetric model of solar atmosphere, which consists of the whole chromosphere and low corona below the 1.25 solar radius. It is a hydrodynamic model with heating in the chromosphere through an artificial energy flux. We performed a series of simulations with our model and found oscillations with a peak frequency of ∼4 mHz in the power spectrum. We confirmed that this resulted from the p-mode excited in the transition region and amplified in a resonant cavity situated in the height range ∼4×103–2×104 km. This result is consistent with global observations of Alfvénic waves in corona and can naturally explain the observational ubiquity of 4mHz without the difficulty of the p-mode passing through the acoustic-damping chromosphere. We also confirmed that acoustic shock waves alone cannot heat the corona to the observed temperature, and found mass upflows in the height range ∼7×103–7×104 km in our model, which pumped the dense and cool plasma into the corona and might be the mass supplier for solar prominences.
Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience
Authors: Gambadauro Antonella , Mollica Salvatore , Rosa Emanuela , Xerra Federica , Li Pomi Alessandra , Valenzise Mariella , Messina Maria Francesca , Vitale Agata , Gitto Eloisa , Wasniewska Malgorzata , Zirilli Giuseppina , Manti Sara
Published: January 2025

Background: Bronchiolitis is the most common cause of lower respiratory tract infection (LRTI) in the first year of life. We analyzed the association between complete blood count (CBC), c-reactive protein (CRP), and novel inflammatory indexes (NLR, PLR, MLR, ELR, LMR, NPR, LPR, LNR, PNR, SII, SIRI) in predicting bronchiolitis severity at hospital admission. Methods: We retrospectively collected data from 95 infants hospitalized for bronchiolitis in a third-level hospital during three epidemic seasons. Five outcomes of severity were analyzed: BRAS; pediatric intensive care unit (PICU) admission; ventilatory support; intravenous (IV) rehydration; and length of stay (LOS). Results: Lower age and weight at admission were statistically associated with four of the five severity outcomes. Prolonged LOS (≥6 days) was associated with high values of total white blood cells, lymphocytes, and eosinophils. Only three inflammatory indexes (PLR, MLR, and PNR) showed a significant association with one outcome (prolonged LOS). A new index (RBC/AiW/1000) was statistically associated with each severity outcome for a value > 350. Conclusions: We proposed a comprehensive analysis of the association between CBC, CRP, and novel inflammatory indexes and bronchiolitis severity. RBC/AiW/1000 could represent a future predictive marker of disease severity at hospital admission in infants with bronchiolitis.
An mRNA-Based Respiratory Syncytial Virus Vaccine Elicits Strong Neutralizing Antibody Responses and Protects Rodents Without Vaccine-Associated Enhanced Respiratory Disease
Authors: Li Jianglong , Long Haiyan , Chen Shaoyi , Zhang Zhendong , Li Shuang , Liu Qi , Liu Jun , Cai Jiaru , Luo Liping , Peng Yucai
Published: January 2025

Background: Respiratory syncytial virus (RSV) causes the most common type of severe lower respiratory tract infection worldwide, and the fusion (F) protein is a target for neutralizing antibodies and vaccine development. This study aimed to investigate the immunogenicity and efficacy of an mRNA-based RSV vaccine with an F protein sequence. Methods: We designed an mRNA construct encoding a modified RSV F protein, which was further developed into an LNP-encapsulated mRNA vaccine (LVRNA007). LVRNA007 was administered to mice and cotton rats, followed by immunogenicity analysis and viral challenge studies. Protection of rodents from the viral infection was evaluated based on the presence of the virus in the lung and pathological examination of respiratory tissues. Results: LVRNA007 induced robust humoral and cellular immune responses in both mice and cotton rats, with neutralization antibody levels in the immunized animals maintained at high levels for over one year. Vaccination of LVRNA007 also protected the rodents from RSV challenge, judged by the much decreased virus titer and the pathological score in the lung tissue. In addition, no vaccine-enhanced disease (VED) phenomenon was observed with LVRNA007 vaccination. Conclusions: Based on the preclinical immunogenicity and efficacy data, LVRNA007 could be a potential promising vaccine for prophylaxis of RSV infection.
Application of Principal Component Analysis as a Prediction Model for Feline Sporotrichosis
Authors: Pegoraro Franco Bresolin , Mangrich-Rocha Rita Maria Venâncio , Weber Saulo Henrique , de Farias Marconi Rodrigues , Schmidt Elizabeth Moreira dos Santos
Published: January 2025

Sporotrichosis is a worldwide zoonotic disease that is spreading and causing epidemics in large urban centers. Cats are the most susceptible species to develop the disease, which could cause significant systemic lesions. The aim was to investigate and to identify predictive indicators of disease progression by correlations between the blood profile (hematological and biochemical analytes) and cutaneous lesion patterns of 70 cats diagnosed with Sporothrix brasiliensis. The higher occurrence in male cats in this study could be related to being non-neutered and having access to open spaces. Principal component analysis (PCA) with two principal components, followed by binary logistic regression, and binary logistic regression analysis, with independent variables and backward elimination modeling, were performed to evaluate hematological (n = 56) and biochemical (n = 34) analytes, including red blood cells, hemoglobin, hematocrit, leukocytes, segmented neutrophils, band neutrophils, eosinophils, lymphocytes, monocytes, total plasma protein, albumin, urea, creatinine, and alanine aminotransferase. Two logistic regression models (PCA and independent variables) were employed to search for a predicted model to correlate fixed (isolated) and disseminated cutaneous lesion patterns. Total plasma protein concentration may be assessed during screening diagnosis as it has been recognized as an independent predictor for the dissemination of cutaneous lesion patterns, with the capability of serving as a predictive biomarker to identify the progression of cutaneous lesions induced by S. brasiliensis infections in cats.
Development and Evaluation of an Immunochromatographic Strip and a Magnetic Chemiluminescence Immunoassay for Detection of Porcine Circovirus Type 2 Antigen
Authors: Tao Sirui , Duan Yu , Zha Yinhe , Tong Xiaxia , He Yulong , Feng Huapeng , Shu Jianhong
Published: January 2025

Porcine circovirus type 2 (PCV2) is the main and primary causative agent of Postweaning Multisystemic Wasting Syndrome (PMWS). To date, immunoperoxidase monolayer assay (IPMA), indirect immunofluorescent assay (IFA), and enzyme linked immunosorbent assay (ELISA) are the most commonly diagnostic methods for detecting PCV2 antigens. However, these methods require specialized equipment and technical expertise and are suitable for laboratory use only. This study aims to develop an immunochromatographic strip and a magnetic chemiluminescence immunoassay for the detection of PCV2 antigens. The recombinant protein was constructed using a prokaryotic expression system, and the polyclonal antibody was obtained by animal experiments. Polystyrene microspheres are used as solid phase carriers to covalently bind to the amino groups of proteins to form immunoprobes. Monodisperse beads are covalently bound to antigens or antibodies as solid phases to bind antibodies or antigens in the liquid phase in a superior manner, thereby capturing and separating antigens and antibodies in the liquid phase. The immunochromatographic strip is qualitative detection method, this method can detect PCV2a strain, PCV2b strain, and PCV2d strain. The immunochromatographic strip had minimum detection limits of 102.89TCID50/0.1 mL, 103.19TCID50/0.1 mL, and 103.49TCID50/0.1 mL for PCV2a/LG, PCV2b/SH, and PCV2d/JH. The results of testing PEDV (CV777 strain), PRV (HB2000 strain), CSFV (WH-09 strain), PRRS (JXA1-R strain), PPV (WH-1 strain), and ASFV (SD strain) were negative. The agreement between the immunochromatographic strip and the ELISA kit was 93.33% (140/150) and the Kappa was 0.866 (Kappa > 0.81). On the premise of ensuring sensitivity, the most important feature of the immunochromatographic strip is that this method can save time when testing; results can be obtained within 5 to 10 min. Magnetic chemiluminescence immunoassay is quantitative detection method; this method can detect PCV2 Cap proteins in swine serum, the linear range of this method was 0.25 ng/mL to 32 ng/mL and R2 of the standard curve was 0.9993. The limit of detection (LOD) is 0.051 ng/mL and the limit of quantitation (LOQ) is 0.068 ng/mL. The agreement between the magnetic chemiluminescence immunoassay and the ELISA kit (test PCV2 Cap proteins) was 97.14% (68/70). This method took less than 30 min to achieve results, which is less than the ELISA kit. The results of this study show that immunochromatographic strip and magnetic chemiluminescence immunoassay for PCV2 antigens had great sensitivity and specificity, which lays the foundation for PCV2 clinical detection.
Photo-Catalytic Reduction of Nitrate by Ag-TiO2/Formic Acid Under Visible Light: Selectivity of Nitrogen and Mechanism
Authors: Shi Yuanyuan , Xie Yi , Xia Jun , Zhang Xiaolin , Cheng Hui , Chen Jialin
Published: January 2025

Ubiquitous nitrate (NO3−) in groundwater sources is considered a hazard compound for human health. Photo-catalytic reduction by Ag-TiO2/formic acid/visible light represents an emerging method for NO3− removal without secondary pollution. In this contribution, the removal of NO3− by photo-catalytic reduction and the selectivity of N2 were systematically investigated under varied conditions, including concentrations of Ag-TiO2, NO3−, and formic acid (HCOOH). The removal efficiency of NO3− reached 84.47%, 82.68% of which was converted to N2 under the optimal conditions: NO3− at 50 mg-N/L, Ag-TiO2 at 1.0 g/L, HCOOH at 20.05 mmol/L, and reaction time at 120 min. The removal of NO3− was enhanced mainly by CO2− rather than by photo-generated electrons or HCOO−. The results of this study indicated that the production of ·CO2− by Ag-TiO2 and HCOOH under visible light catalysis can achieve efficient NO3− removal.
Assessment of Radioactivity Concentrations and Associated Radiological Health Risk in Natural Spring Mineral Bottled Drinking Water from South Africa
Authors: John Samuel Odumu Ogana , Olukotun Stephen Friday , Mathuthu Manny
Published: January 2025

Naturally occurring radionuclides are ubiquitous at various levels of concentration, while exposure to ionizing radiation by humans is of global concern. Radiological health risk assessment due to the consumption of natural spring mineral water is critical for ensuring public health and safety. This study aims at investigating the radioactivity concentration levels of natural radionuclides 226Ra, 232Th and 40K and the associated radiological health risk in commercial natural spring bottled water in South Africa. A total of 21 of the most-consumed bottled drinking water brands from grocery stores, were analysed using the HPGe gamma detector. The results indicate that the range of radioactivity concentrations is from 1.060 ± 0.067 to 2.571 ± 0.143 BqL−1, with a mean of 1.766 ± 0.399 BqL−1 for 226Ra; 1.736 ± 0.112 to 7.807 ± 0.099 BqL−1, with a mean of 3.688 ± 1.371 BqL−1 for 232Th and 149.000 ± 38.480 to 242.900 ± 59.700 BqL−1 with a mean of 220.229 ± 22.297 BqL−1 for 40K. The potential radiological health risks evaluated show mean values for Raeq, DAb, AEID and AGED as 23.976 ± 0.446 BqL−1, 12.232 ± 1.445 nGyh−1, 0.060 ± 0.007 mSvy−1 and 0.090 ± 0.027 mSvy−1, respectively. The radiation dose based on age group is in the order of infants (≤1 year) > teenagers (12–17 years) > children (1–12 years) > adults (>17 years). The activity concentrations of radionuclides in bottled water are ranked in the order of 40K > 232Th > 226Ra, with 232Th contributing the highest radiation dose, consistent with findings reported in previous studies. The findings reveal that the activity concentration levels and estimated radiological health risks are within the permissible limits set by UNSCEAR guidelines. Therefore, the consumption of bottled water is radiologically safe. However, the findings also suggest that 12 out of 1000 individuals may suffer cancer fatality, while 6 out of 1 million individuals may experience hereditary effects over their lifetime from the consumption of bottled water. Regular monitoring and stringent regulatory controls are recommended to ensure the radiological safety of bottled drinking water in South Africa.
Comprehensive Analysis of Microplastic Abundance in Macrophytes, Macrophyte-Associated Sediments, and Water in Tropical Coastal Lagoons in Sri Lanka
Authors: Rathnayake R. M. L. I. , Amarathunga A. A. D. , De Silva D. S. M. , McGoran A. R. , Bakir A. , Sivyer D. B. , Reeve C. , Narangoda S. R. C. N. K.
Published: January 2025

The prevalence and fate of microplastics in macrophytes are insufficiently understood, and data on the abundance of microplastic (MP) accumulation in macrophyte ecosystems are urgently needed to fill this knowledge gap. The main objectives of this study were to quantify and characterize the microplastics that accumulate in macrophytes, associated sediments, and water in Negombo Lagoon, Sri Lanka. The investigation was conducted with specialized sampling and extraction techniques. Microplastics were detected by the fluorescence tagging of polymers using Nile red, and polymer identification was conducted by ATR-µFTIR and ATR-FTIR. This study revealed variations in microplastic abundance across different macrophyte species. Gracilaria sp. had a higher abundance of 9 ± 3 items g−1 wet weight, followed by Chaetomorpha sp. at 8 ± 3 items g−1 wet weight and Halodule pinifolia at 6 ± 1 items g−1 wet weight. The root surfaces of these species had slightly similar levels of abundance. Both blue and transparent microplastics were predominant. Fragments (>47%) were found at a higher percentage in macrophyte samples, but high fiber contents (>60%) were found in associated sediment and water samples. Nevertheless, macrophyte samples contained a higher percentage of fragments in the size range of 50–150 μm. This comprehensive study contributes to expanding our awareness regarding the influence of microplastic pollution on macrophyte ecosystems.
Evaluation of Hydraulic Performance of Sewage Pipe Networks
Authors: Li Peng , Zhang Yitao , Zhao Peng , Gu Dongmei , Wang Shaohua
Published: January 2025

With the continuous increase in the urbanization rate, the amount of sewage received by the sewage pipe network has also been increasing annually. The phenomenon of high water level operation in sewage pipe networks has emerged in many cities, which seriously affects drainage efficiency. Therefore, constructing an effective evaluation method to assess the hydraulic performance of pipe networks operating at high water levels, as well as identifying high-risk pipelines, formulating cost-effective rehabilitation schemes, and evaluating the rehabilitation effects has become necessary to solve this problem. In this study, a sewage pipe network hydraulic performance evaluation method based on flow velocity, pipe fullness, and manhole fullness was established. This method comprehensively considers the instantaneous values and cumulative operation durations of each indicator in the pipeline and, thus, can accurately evaluate the hydraulic performance of the pipe network. This method was applied to the sewage pipe network in City H, and it was found that there existed problems such as low flow velocity, unreasonable pipe diameter, overloading, and high risk of overflow. After the renovation of specific pipeline sections according to the evaluation results, the comprehensive hydraulic performance of the pipe network was significantly improved, with the grade rising from “poor” to “medium +”. This research shows that this evaluation method can accurately assess the hydraulic performance of the current and the renovated sewage pipe network, providing scientific guidance for the renovation and optimization.
Sustainable Urban Mobility: Corridor Optimization to Promote Modal Choice, Reduce Congestion, and Enhance Livability in Hyderabad, Pakistan
Authors: Soomro Mehnaz , Memon Irfan Ahmed , Chandio Imtiaz Ahmed , Kalwar Saima , Marvi Hina , Kumar Aneel , Memon Afraz Ahmed
Published: January 2025

This research aims to optimize corridors in Hyderabad, Sindh, to promote modal choice, reduce congestion, and enhance livability. This study focused on developing and evaluating multimodal wide corridor routing methods, analyzing the modal choice behavior of travelers using a generalized cost model and a mixed constant and separate user balance model, and implementing and assessing innovative road space management strategies. The data were collected using GIS (Geographical Information System) to compare the performance and impacts of the proposed methods and techniques with existing ones, such as shortest path, minimum interference, maximum capacity, and lane addition, using various performance measures, such as travel time, modal share, congestion level, environmental impact, safety, and equity. This research aims to optimize corridors in Hyderabad, Sindh, to encourage various transportation options, such as the BRT system and Peoples Bus Service, to reduce congestion and enhance livability by developing and accessing different methods and strategies. This study analyzed available data through a geospatial perspective to optimize corridors in Hyderabad, Sindh, focusing on multimodal routing methods, modal choice behavior, and innovative road space management strategies to enhance urban livability rather than relying on simulation software or field-collected data.
Estrés en docentes del distrito 13D09-Paján, Manabí
Authors: Ruiz Ruiz Tanya Elizabeth , Giniebra Urra Ricardo , Rodríguez Álava Leonor Alexandra
Published: January 2025

Resumen
La presente investigación tiene como objetivo determinar el nivel estrés en docentes del Distrito 13D09-Paján, Manabí, para lo cual se realiza una revisión y fundamentación bibliográfica del concepto de estrés de acuerdo a las últimas investigaciones y particularizando en los docentes. Se aplicó el enfoque mixto, el tipo de investigación fue de campo y descriptiva, empleando el método deductivo, analítico-sintético, descriptivo y estadístico; las técnicas usadas fue la entrevista y la encuesta, siendo los instrumentos el Cuestionario de Evaluación de Estrés en Docentes (Teachers' Stress Inventory, TSI); se concluye que los docentes presentan diversos y significativos niveles de estrés pero que la autoridad no tiene ninguna estrategia para enfrentarlo y restaurar el bienestar de los maestros.
Embarazo adolescente: una revisión sistemática de factores individuales, familiares y sociales asociados
Authors: García Vinces Elizabeth Patricia , Valdivieso Cobeña Martin Augusto
Published: January 2025

A nivel mundial, las tasas del embarazo en la adolescencia están en aumento, de manera especial en los países en vías de desarrollo, lo que conlleva a efectos negativos en la esfera biopsicosocial de las adolescentes y de su entorno familiar. El objetivo es determinar la asociación entre el embarazo en adolescentes y factores individuales, familiares y sociales. Para esto se realizó una revisión sistemática, la búsqueda se efectuó en cinco bases electrónicas: Pubmed, Sciencie Direct, Scielo, Redalyc y Latindex y se utilizaron los términos MeSH (Medical Subject Headings) "Teen pregnancy" o "pregnant teen" y los Descriptores en Ciencias de la Salud (DeCS) “embarazo en adolescentes” o “adolescente embarazada”. Se incluyeron 19 estudios, publicados desde el año 2015 al 2020, con cuartiles de la (Scimago Journal & Country Ranking) del 1 al 4, en inglés, español y portugués. Como resultados se encontró que factores de riesgo como la disfuncionalidad familiar y pobreza en el hogar tuvieron asociación estadísticamente significativa para embarazo en las adolescentes. Otros factores que estuvieron asociados fueron el inicio precoz de las relaciones sexuales, el desconocimiento de métodos anticonceptivos, el bajo nivel, ser residente de áreas rurales y el bajo nivel de instrucción de los progenitores. Como conclusión esta revisión enfatiza que los factores individuales, familiares y sociales están asociados al embarazo en la adolescencia. Como limitación se encontró que la mayoría de las publicaciones requerían subscripción y pago previo, por lo que se optó en otras bases de datos, como Pub Med y Scielo.
Association between video consultation use and general practitioner and practice characteristics: a cross-sectional survey in Denmark
Authors: Prætorius Thim , Klausen Fredslund Eskild , Torp Daniel Cæsar , Sandbaek Annelli
Published: January 2025

Background

Video consultations (VC) disrupt how general practice provides care and how patients receive it. A step towards understanding the use of VC is to study the association between user-status and general practitioner and practice characteristics.

Aim

To study the association between general practitioner and general practice characteristics and VC user-status (users, never users, and former users).

Design & setting

An anonymous, web-based, cross-sectional survey was distributed to all 1674 Danish general practices (singlehanded, collaborative, and partnership forms) contracting with and working on a collective agreement with the public funder.

Method

Multinomial logistic regression was used to correlate VC user-status and (1) general practice characteristics, and general practitioners' (2a) objective characteristics and (2b) subjective attitudes towards VC and organizational change.

Results

The study sample included 416 general practitioners. Users of VC compared to never-users: partnership practices (RRR=0.22; 95% CI 0.06-0.85) and practices with six or more practice staff (RRR=0.05; 95% CI 0.01-0.28) were significantly more likely to be users. The same was found for general practitioners with a high degree of tech savviness (RRR=0.02; 95% CI 0.001-0.17) and openness to organisational change (RRR=0.26; 95% CI 0.08-0.85).

Conclusion

Characteristics of general practice and general practitioners are associated with VC user-status (being a user, never user or former user). Future research should use a Difference-in-Difference study design and register data to make causality claims.
PENGARUH IMBANGAN TAPE KETAN HITAM DAN BUAH NAGA MERAH TERHADAP MUTU ORGANOLEPTIK PADA SNACK BAR DIABETES MELITUS
Authors: Hapsari Agustina Indri , Widartika Widartika
Published: January 2025

Oxidative stress in DM patients can be inhibited by consuming foods that are high in antioxidants. Black glutinous tape and red dragon fruit were chosen as snack bar ingredients because they contain high fiber, low Glycemic Index (IG), and high antioxidants. The study aimed  to analyze the organoleptic quality of the formulation of black glutinous rice tape snack bars and red dragon fruit. The design of this study was experimental with a Complete Random Design (RAL) consisting of independent variables and dependent variables. The independent variable was the balance of black sticky rice tape: red dragon fruit F1=75:25, F2=60:40, and F3=50:50. The dependent variable is the organoleptic quality of the Snack Bar DM product. The hedonic test involved 30 moderately trained panelistsThe analysis used was the One-Way Anova test and the Duncan follow-up test. The results showed that there was no difference in terms of color, aroma and texture in the three black glutinous rice snack bar and red dragon fruit snack bar formulas. However, there were organoleptic differences in taste in various balances of black glutinous rice tape snack bars and red dragon fruit p=0.032. Duncan's test results show that the best snack bar flavor is a snack bar with formula 3 with a balance of 50% black glutinous tape: 50% red dragon fruit.
Методологія та організація наукових досліджень
Authors: Федотова Оксана , Кудлай В'ячеслав
Published: January 2025

Навчальний посібник «Методологія та організація наукових досліджень» призначений для здобувачів вищої освіти другого (магістерського) рівня за освітньо-професійною програмою «Керування документаційними процесами та розвиток цифрової громади» спеціальності 029 «Інформаційна, бібліотечна та архівна справа». У ньому розкрито основні аспекти методології та організації наукової діяльності, що дозволяє студентам оволодіти теоретичними знаннями та практичними навичками, необхідними для проведення досліджень.

Посібник містить структурований виклад матеріалу, що охоплює етапи підготовки, проведення і впровадження результатів наукових досліджень, використання емпіричних і теоретичних методів, обробку та оформлення наукових результатів. Особлива увага приділяється принципам академічної доброчесності, методологічним підходам, а також вимогам до написання та захисту магістерських робіт.

Книга включає теоретичний виклад, прикладні завдання, тестові питання для самоперевірки, а також список рекомендованої літератури, що сприяє інтеграції навчального матеріалу та розвитку дослідницьких компетентностей студентів. Видання буде корисним як для студентів, так і для викладачів.
Formação inicial e a construção de saberes do professor de língua portuguesa: perspectivas de alunos egressos
Authors: Araújo Beatriz Costa , Oliveira Célia Zeri de
Published: January 2025

O artigo possui o intuito de demonstrar a investigação da maneira como vem sendo abordados os saberes docentes no curso de Licenciatura em Letras – Língua Portuguesa da Universidade Federal do Pará. Partindo do princípio de que a profissão docente é formada por diferentes saberes e que estes advêm de diversos campos, como a formação profissional inicial e continuada (Tardif, 2008), buscamos investigar o modo como os professores já formados pela instituição, egressos do curso, estão compreendendo conceitos essenciais para a sua formação. Para isso, utilizamos teorias acerca dos saberes docentes (Tardif, 2008; 1996; Pimenta, 1999; Nóvoa, 2009) como aporte teórico. A pesquisa é de cunho qualitativo, caracterizada como estudo de caso e utilizou um questionário on-line para coletar as informações objetivadas. Como resultado, chegamos à conclusão de que os egressos apontam para uma carência de mais disciplinas pedagógicas ao longo de suas formações iniciais e que o curso de Letras da UFPA necessita reavaliar a matriz curricular utilizada.
Assistência ao pré-natal e panorama sociodemográfico de nascidos vivos prematuros no Centro-Oeste brasileiro
Authors: Vidal Anna Carolina Cacciari , Aranão Giulia Deziró , Alvarenga Vívien Barros , Tonus Larissa da Costa , Maia Clécio André Alves da Silva
Published: January 2025

Considerando o panorama das gestantes e dos partos prematuros no Brasil, o presente estudo tem como objetivo apresentar dados epidemiológicos sobre partos pré-termo e controles pré-natais e associar neonatos prematuros ao baixo e irregular controle fetal ao longo da gravidez na região do Centro-Oeste brasileiro. Para isso, utilizou-se de um caráter transversal de pesquisa, coletando dados através do Sistema de Informações de Nascidos Vivos (SINASC), presente na plataforma do Departamento de Informação e Informática do Sistema Único de Saúde (DATASUS/Tabnet), a partir de variáveis que se relacionam como a hipótese em pauta, como idade materna, taxa de partos prematuros, números de consultas pré-natais realizadas, entre outros, no período de 2018 a 2023. Desse modo, evidenciou-se que a região estudada teve o menor número de prematuros em relação ao resto do país, porém, ao compará-la ao Brasil como um todo, percebe-se que é a única que foi na contramão da tendência nacional em diminuir os casos de bebês pré-termo. Além disso, quanto ao cuidado pré-natal, nota-se uma tendência a pacientes com pré-natal adequado em proporções similares às com cuidados inadequados, diminuindo o número de mulheres com controles intermediários. Logo, conclui-se que na região selecionada para desenvolver o presente estudo, as mulheres mais jovens e pardas foram as que mais tiveram neonatos pré-termo e além disso, o Centro-Oeste mostra ascensão nos casos de prematuridade, algo que reflete a importância na melhora dos controles regulares prévios ao nascimento.
Qualidade de vida infantil: uma revisão integrativa comparativa entre epilepsia e autismo
Authors: Barroso Luciana Karla Viana , Antúnez Andrés Eduardo Aguirre , Amaral Amanda Costa do , Pereira Angela Sabryne Maria , Lage Ariane Ribeiro , Lima Maria Eduarda Pereira de , Cascudo Pedro de Luca Pereira , Tavares Wanderson Pablo Galdino
Published: January 2025

Epilepsia e Transtorno do Espectro Autista (TEA) são condições neurológicas crônicas que comprometem múltiplos domínios da qualidade de vida, incluindo aspectos físicos, emocionais, sociais e cognitivos. Na epilepsia, fatores como comorbidades físicas, distúrbios do sono, dificuldades de adaptação escolar e o impacto na saúde mental dos cuidadores comprometem a qualidade de vida. No TEA, os déficits na comunicação, comportamentos repetitivos, comorbidades psiquiátricas e distúrbios do sono são determinantes críticos.O objetivo deste estudo foi comparar a qualidade de vida de crianças com epilepsia e TEA, analisando os impactos de cada condição no desenvolvimento neuropsicomotor, nas relações sociais, na saúde mental e no bem-estar geral. Para isso, foi realizada uma revisão integrativa da literatura, incluindo 20 artigos publicados nos últimos 5 anos. Esta revisão evidenciou que, em ambas as condições, comorbidades como distúrbios psiquiátricos e problemas do sono estão associados a uma qualidade de vida inferior. No entanto, cada condição requer intervenções direcionadas que abordem suas comorbidades específicas, incluindo o suporte ao cuidador. Além disso, as limitações metodológicas e o predomínio de estudos ocidentais destacam a necessidade de pesquisas com amostras mais diversificadas para uma análise mais abrangente.
Fake news e desinformação impactam na baixa cobertura vacinal infantil
Authors: Daniel Hiran Brenan Sivieri , Silva Pérola Liciane Baptista da Cruz e , Roque Andrea Cibele , Gonçalves Ivana Regina
Published: January 2025

A imunização é uma das medidas mais eficazes para proteger pessoas contra infecções e doenças, sendo as crianças e adolescentes os grupos prioritários. No entanto, a ocorrência de movimentos que disseminam informações falsas sobre vacinas geram resistência à vacinação infantil. Segundo o Ministério da Saúde, as fake news intensificam problemas antigos ao espalhar informações falsas que geram preocupações e desinteresse na imunização infantil. Este estudo investigou a relação entre fake news e a baixa cobertura vacinal infantil, por meio de uma revisão bibliográfica de 2019 a 2023 nas bases Google Acadêmico, Scielo e COFEN. Foram analisados 23 artigos, dos quais 7 foram excluídos por não se adequarem à proposta. Os artigos selecionados foram organizados em categorias segundo a análise de conteúdo de Bardin (1977): fake news, desinformação, hesitação e falta de informação. Concluiu-se que a manutenção da cobertura vacinal é essencial no combate a várias doenças e pode ser comprometida por fake news.
Divertículo jejunal em borda antimesentérica em hérnia inguinal estrangulada
Authors: Ochiussi Amanda Morales , Melo Mariana França Bandeira de , Junior Ulisses Inacio da Silva
Published: January 2025

Divertículo jejunal é uma afecção rara, mais comum em idosos, que pode apresentar diversas complicações, de difícil diagnóstico, visto raridade e ausência de sintomas típicos. O objetivo do relato é apresentar um caso de paciente com divertículo jejunal que acarretou em obstrução intestinal, inflamação local e perfuração diverticular.
Odontoma composto: relato de caso
Authors: Junior Marcus Antônio Brêda , Melo Thalita Medeiros , Silva Arthur Barros da , Silva Gabriel Olival de Sena , Filho Jânio Gomes Duarte , Silva Kalyne Soares da , Silva Luiz Arthur Barbosa da , Cerqueira Pedro Henrique Malta
Published: January 2025

O odontoma é um tipo de tumor odontogênico de origem mista, podendo ser classificado como composto ou complexo. O odontoma composto é caracterizado por ter a aparência semelhante a de dentículos ou de um grupo de dentes rudimentares. Nesse relato, paciente do gênero feminino, 22 anos, compareceu a clinica odontológica da UNIMA para realizacão de uma exodontia e descobriu uma coleção de estruturas que se assemelhavam a dentes, através de uma radiografia panorâmica. A hipótese diagnostica sugerida foi de odontoma, sendo o melhor intervenção sugerida a remoção cirurgica. O objetivo deste trabalho é relatar um caso de odontoma composto localizado em região anterior de maxila e tratado por meio da enucleação total da lesão, de maneira precoce a fim de evitar complicações futuras.
Potencialidades da musicoterapia no tratamento oncológico: uma revisão narrativa
Authors: Rodrigues Isabely Pereira , Ornellas Bruna de Castro , Ribeiro Caline dos Santos , Almeida Gabriel de Souza , Nascimento Erika Fabris do
Published: January 2025

Considerando os impactos que o tratamento oncológico exerce na vida dos pacientes, tanto físicos quanto emocionais, este estudo tem como objetivo identificar na literatura cientifica as potencialodades da musicoterapia para aliviar os sinais e sintomas em pacientes sob tratamento oncológico. Para tanto, realizou-se uma revisão da literatura, de caráter descritivo e qualitativo, com foco na seguinte questão norteadora: “Quais são os benefícios da musicoterapia em pacientes sob tratamento quimioterápico?”. A pesquisa incluiu artigos gratuitos, publicados nos últimos cinco anos, em português e inglês. Foram analisados 09 estudos que evidenciaram os benefícios da musicoterapia no contexto oncológico. Observou-se que a musicoterapia tem efeitos positivos no alívio da dor e no fortalecimento do bem-estar emocional, uma vez que a música ativa áreas do cérebro associadas ao processamento das emoções e pode influenciar a percepção da dor. Conclui-se, portanto, que a musicoterapia representa uma intervenção promissora nos cuidados oncológicos, promovendo melhorias significativas na qualidade de vida.
Avanços no tratamento de cicatrizes de queimaduras: novas tecnologias e terapias emergentes
Authors: Oliveira Vitor Hugo , Mota Isabella Amaral , Viana Matheus Lacerda , Fonsceca Edson Freire
Published: January 2025

Queimaduras possuem um impacto significativo na saúde pública, principalmente no Brasil, onde cerca de um milhão de pessoas são afetadas anualmente. O presente estudo tem como objetivo avaliar as novas tecnologias no tratamento de queimaduras, comparando-as com abordagens convencionais, de forma a identificar as mais eficazes, suas indicações e pontos positivos e negativos. Foram realizadas pesquisas nas bases BVS, PubMed, EBSCO e Google Acadêmico, resultando na seleção de 19 artigos. Dentre os artigos revisados, foi evidenciada a importância da abordagem inicial ao paciente queimado, destacando o protocolo ABCDE e a remoção precoce do tecido necrótico. Ademais, para que os malefícios de tais lesões sejam reduzidos, novas tecnologias foram criadas, as quais têm se mostrado alternativas promissoras. Entre as principais inovações estão o uso de xenoenxertos, que acelera a cicatrização e melhora a qualidade do tecido regenerado, e as terapias com células-tronco, que auxiliam no reparo e regeneração tecidual. Além disso, os retalhos microcirúrgicos desempenham um papel crucial em queimaduras graves, garantindo a cobertura adequada de áreas extensas. Tais inovações mostraram benefícios tanto na restauração da funcionalidade, que é o principal objetivo das intervenções em queimaduras, quanto na estética da área lesada. Após análise dos artigos, concluiu-se que o uso adequado dessas novas formas de tratamento trouxe melhorsa na cicatrização, estética e funcionalidade, bem como redução das complicações. Embora os benefícios sejam indubitáveis, o artigo aponta desafios, como o alto custo, a necessidade de capacitação adequada dos médicos e de mais pesquisas para validar a eficácia dessas terapias a longo prazo.
Pseudo-microangiopatia trombótica secundária a deficiência de vitamina B12: um relato de caso
Authors: Soprani Jhessika Rosa , Hernandes Bruna Luiza Tavares , Dias Marco Túlio , Almeida Higor Teixeira de , Ribeiro Renata Cristina Teixeira
Published: January 2025

A pseudo-microangiopatia trombótica (PMAT) é uma manifestação rara da deficiência de vitamina B12, observada em aproximadamente 2,5% dos casos. Caracteriza-se por anemia hemolítica, trombocitopenia e presença de esquizócitos no sangue periférico, sendo frequentemente confundida com a púrpura trombocitopênica trombótica (PTT), embora não apresente agregados plaquetários intravasculares típicos desta. A fisiopatologia da PMAT envolve o comprometimento da síntese de DNA, resultando em eritropoiese ineficaz, apoptose celular e formação de eritrócitos com membranas frágeis, susceptíveis à destruição precoce. O tratamento baseia-se na reposição de cobalamina, promovendo a resolução das alterações clínicas e laboratoriais. Este artigo relata um caso de PMAT secundária à deficiência de vitamina B12, destacando a relevância de um diagnóstico diferencial preciso para evitar terapias inadequadas.
Gestação e DIU de cobre em útero bicorno
Authors: Lenzi Bruna Danielle , Colombo Rafael Ribeiro , Colombo Fernanda Ribeiro , Leão Paulo Roberto Dutra
Published: January 2025

Trata-se de um relato de caso de uma paciente diagnosticada com útero bicorno na quinta gestação, associado à presença de dispositivo intrauterino (DIU) de cobre como método contraceptivo. Sabe-se que o útero bicorno aumenta consideravelmente o risco de aborto espontâneo durante a gestação e a presença do DIU leva a um aumento ainda maior nos estágios iniciais da gestação, ou mesmo ao desenvolvimento de uma forma ectópica. Após ampla pesquisa em bases de dados, nenhum caso semelhante foi identificado na literatura, tornando assim esta descrição relevante. Com isso, objetiva-se chamar a atenção do caso para possíveis condições semelhantes e, assim, maior conhecimento sobre o manejo adequado.
Mesenchymal Stem Cells Carrying Viral Fusogenic Protein p14 to Treat Solid Tumors by Inducing Cell–Cell Fusion and Immune Activation
Authors: Wang Yao , Pang Xunlei , Li Ruirui , Chen Jiuzhou , Wen Chen , Zhu Huihuang , Long Tingyu , Li Jianjie , Zheng Lijun , Deng Youcai , Zheng Junnian , Xu Bo
Published: January 2025

Background:
Chimeric antigen receptor (CAR)-based immune cell therapies attack neighboring cancer cells after receptor recognition but are unable to directly affect distant tumor cells. This limitation may contribute to their inefficiency in treating solid tumors, given the restricted intratumoral infiltration and immunosuppressive tumor microenvironment. Therefore, cell–cell fusion as a cell-killing mechanism might develop a novel cytotherapy aimed at improving the efficacy against solid tumors.
Methods:
We constructed a fusogenic protein, fusion-associated small transmembrane (FAST) p14 of reptilian reovirus, into cancer cells and mesenchymal stem cells (MSCs), which cocultured with various colon cancer cells and melenoma cells to validate its ability to induce cell fusion and syncytia formation. RNA sequencing, quantitative reverse transcription polymerase chain reaction, and Western blot were performed to elucidate the mechanism of syncytia death. Cell viability assay was employed to assess the killing effects of MSCs carrying the p14 protein (MSCs-p14), which was also identified in the subcutaneous tumor models. Subsequently, the Tet-On system was introduced to enhance the controllability and safety of therapy.
Results:
Cancer cells incorporated with fusogenic protein p14 FAST from reovirus fused together to form syncytia and subsequently died through apoptosis and pyroptosis. MSCs-p14 cocultured with different cancer cells and effienctly induced cancer cell fusion and caused widespread cancer cell death in vitro. In mouse tumor models, mMSCs-p14 treatment markedly suppressed tumor growth and also enhanced the activity of natural killer cells and macrophages. Controllability and safety of MSCs-p14 therapy were further improved by introducing the tetracycline-controlled transcriptional system.
Conclusion:
MSC-based cytotherapy carrying viral fusogenic protein in this study kills cancer cells by inducing cell–cell fusion. It has demonstrated definite efficacy in treating solid tumors and is worth considering for clinical development.
Analisis Penyebab Utama Dan Peningkatan Kualitas Yarn Fault Pada Proses Winding Cotton Compact Ne 40 UW: Pendekatan Empiris
Authors: Darmawi Ahmad , Rendy Stiyaji  , Sih Parmawati
Published: January 2025

This study aims to identify and analyze the main factors contributing to the high yarn fault rates in the winding process of Cotton Compact Ne 40 UW production at PT Tantra Textile Industry. The methodology employed includes an ex post facto approach, direct observation, and historical data analysis from the Ring Spinning Frame (RSF) and winding machines. The findings reveal that Short Thick and Long Thick faults are the most dominant types, accounting for over 60% of the total detected faults, primarily due to variations in yarn thickness beyond control limits. Additionally, unstable environmental conditions and suboptimal machine cleanliness were found to exacerbate the quality of the yarn. These findings emphasize the need for stricter control over environmental parameters and improved machine maintenance to enhance yarn quality. The practical implications of this research include the implementation of advanced environmental monitoring systems and intensive machine maintenance programs. This study makes a significant contribution to the literature by providing detailed empirical analysis of the factors affecting yarn quality during the winding stage and offering data-driven recommendations for improving textile production quality.
Factors affecting carotid artery intima-media thickness in children with chronic kidney disease
Authors: Esfandiar Nasrin , Khalili Mitra , Mohkam Masoumeh , Hajipour Mahmood , Tajziehchi Golsa , Rashki Ghalenoo Sara
Published: January 2025

Introduction: Cardiovascular disease is associated with chronic kidney disease (CKD) in both children and adults. It is difficult to assess cardiovascular status in children for various reasons, such as the lack of clinical manifestations in the early stages of cardiovascular disease. One of the methods for assessing the cardiovascular status of patients is to assess the carotid intima-media thickness (CIMT). However, only limited studies have been conducted on children to date. Objectives: This study aimed to investigate factors affecting CIMT in children with chronic renal failure. Patients and Methods: This case-control study evaluated the CIMT of children hospitalized with CKD in Mofid children’s hospital (Tehran, Iran) from 2019 to 2021. All children with CKD were selected during the three-year period as the case group of 50 people. The control group was randomly selected from 150 people who were referred to other departments. Medical record information and detailed clinical examinations, laboratory and biochemical tests, and ultrasound examination of CIMT were recorded and analyzed. A significance level of 0.05 was considered. Results: This study showed, 52% of the patients were boys and the rest were girls (P=0.80). The mean age in the patient group was 76.9±10.4 months since the mean age of control group was 32.8±3 months (P=0.008). The mean weight in the patient group was lower than in the control group (P=0.0004). The median CIMT in the patient group was significantly higher than in the control group (right and left CIMT for the patient group 0.48 mm and for the control group of the right and left carotid 0.41 mm and 0.42 mm, respectively; P< 0.05). We also found age, weight, mean corpuscular volume (MCV), serum vitamin D and uric acid levels and also blood glucose concentration were correlated with the CIMT (P<0.05). Conclusion: It is concluded that CIMT is a useful method for assessing the cardiovascular status of children with CKD.
A rare case of a giant intrathyroidal parathyroid adenoma only localized with a 4D CT scan
Authors: Shahid Ibrahim , Ren Jing
Published: January 2025

Ectopic parathyroid adenomas (PTAs) are quite rare and are typically located within the thymus, retroesophageal space, retropharyngeal space, or within the thyroid gland. Likewise, intrathyroidal parathyroid adenomas (IPAs) and giant PTAs are also a rare subset of PTAs. To date, only six studies have investigated localizing techniques of IPAs using 4-dimensional computed tomography (4D CT) scan with only one study demonstrating two IPAs successfully localized using both 4D CT scan and 4-dimensional magnetic resonance imaging. We describe a single lesion in a patient which would be classified both as an IPA and a giant parathyroid adenoma (GPA). This lesion only successfully localised with a 4D CT scan which is not in keeping and unusual with the available literature.