bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and safety of netakimab, a novel anti-IL-17 monoclonal antibody, in patients with moderate to severe plaque psoriasis. Results of a 54-week randomized double-blind placebo-controlled PLANETA clinical trial
Authors: Puig Luis , Bakulev Andrey L. , Kokhan Muza M. , Samtsov Alexey V. , Khairutdinov Vladislav R. , Morozova Maria A. , Zolkin Nikita A. , Kuryshev Ivan V. , Petrov Alexey N. , Artemeva Antonina V. , Zinkina-Orikhan Arina V.
Published: November 2021

Background. Netakimab (NTK), an original humanized anti-interleukin-17 monoclonal antibody, showed therapeutic efficacy in moderate to severe plaque psoriasis in a phase 2 clinical study. Herein we report the results of 54 weeks of a phase 3 trial.
Aim. To evaluate the efficacy and safety of two NTK regimens vs. placebo in moderate to severe plaque psoriasis.
Methods. PLANETA is the ongoing randomized double-blind placebo-controlled clinical trial. 213 patients with moderate to severe plaque psoriasis were randomly assigned to receive NTK 120 mg once every 2 weeks (NTK Q2W), NTK 120 mg once every 4 weeks (NTK Q4W) or placebo. During the first 3 weeks, patients received subcutaneous injections of NTK or placebo (according to the allocation) once a week. Patients in the NTK Q2W group then received NTK at weeks 4, 6, 8, and 10. Subjects in the NTK Q4W group received NTK at weeks 6 and 10 and placebo at weeks 4 and 8. Patients in the placebo group received placebo injections at weeks 4, 6, 8, and 10. Treatment was unblinded at week 12. During the open-label phase, patients in both NTK groups continued to receive NTK Q4W. The primary efficacy endpoint was the proportion of patients in each group who achieved a 75% or greater reduction from baseline in psoriasis area and severity index (PASI 75) at week 12.
Results. A total of 77.7%, 83.3%, and 0% of patients had a PASI 75 response at week 12 in the NTK Q2W, NTK Q4W, and placebo groups, respectively (P 0.0001, Fishers exact test, ITT). The effect was maintained throughout the 1-year treatment. NTK showed a good safety profile and low immunogenicity.
Conclusion. Treatment with NTK results in high rates of sustained clinical response in patients with moderate to severe plaque psoriasis. The study is ongoing; thus, long-term use efficacy and safety data are forthcoming.
Genetic markers for psoriatic arthritis in patients with psoriasis. Part I: non-HLA genes
Authors: Kubanov Alexey A. , Karamova Arfenya E. , Chikin Vadim V. , Verbenko Dmitry A. , Znamenskaya Lyudmila F. , Artamonova Olga G.
Published: November 2021

Psoriatic arthritis often develops in patients with psoriasis and can lead to joint deformity, stiffness, dysfunction, and disability. Psoriatic arthritis is a polygenic disease. and the issue of personalizing the prognosis of its development can only be resolved taking into account the variability of plenty genomic loci associated with the development of the disease. The personification of the prognosis of the disease can be solved taking into account the variability of the set of genomic loci with which its development is associated. The review examines genomic polymorphisms associated with the development of psoriatic arthritis not psoriasis, except of HLA polymorphisms. Genome regions containing polymorphisms, allelic variants of which are associated both with the development of psoriatic arthritis and reducing the likelihood of its occurrence, are described. It has been reported that the predisposition to the development of psoriatic arthritis in patients with psoriasis is determined by genes encoding proteins involved in inflammation and bone metabolism.
Dermatovenereology of Russian Federation in 2020: Working Under a Pandemic
Authors: Kubanov Alexey A. , Bogdanova Elena V.
Published: November 2021

The article presents an analysis of the resources and activities of medical organizations providing medical care in the field of dermatovenereology for the period 20152020. Up-to-date data on the number of medical organizations and units providing specialized medical care in the field of dermatovenereology are provided. A description of the main changes in the provision of the population of the Russian Federation with dermatovenereologists, staffing with dermatovenereologists of medical organizations is given. Changes in the number of outpatient visits in 2020 are given. The dynamics of the bed fund of 24-hour and day hospitals of a dermatovenereological profile, the bed occupancy, the number of patients treated is described. The data on the incidence of sexually transmitted infections, infectious skin diseases are presented. Prevalence and incidence rates of diseases of the skin and subcutaneous tissue, including atopic dermatitis and psoriasis, are given. The impact of measures aimed at preventing the spread of a new coronavirus infection and organizing the provision of medical care to patients with COVID-19 on the performance rates of dermatovenereologic medical organizations has been demonstrated.
Description of a gynander of Colletes hedini (Hymenoptera: Colletidae) from the Qinghai-Tibetan Plateau, China: the first record of gynandromorphism for the genus after 30 years
Authors:   Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China, Ferrari R.R. , Onuferko T.M. ,   Canadian Museum of Nature, Ottawa, ON K1P 6P4, Canada, Zhu C.D. ,   Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China,   University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 10049, China,   State Key Laboratory of Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China
Published: November 2021

The first known gynander of the East Asian cellophane bee Colletes hedini Kuhlmann (Hymenoptera: Colletidae) is described and imaged. We provide an illustrated differential diagnosis based on the terminalia, which are entirely male. We also DNA barcoded the gynander to confirm its identity, and the complete barcode sequence is made public. In the single specimen discovered, the distribution of female and male tissues is patchy and random (i.e., not split among tagmata or along a particular axis of the body) and thus the individual can be categorized as a mosaic gynander. This discovery represents one of only a few confirmed cases of gynandromorphism in colletid bees and the second in Colletes.
A new species and a new record of the ant genus Ooceraea Roger, 1862 (Hymenoptera: Formicidae: Dorylinae) from Thailand
Authors:   Office of Natural Science Research, National Science Museum, 39 moo 3, Khlong 5, Khlong Luang, Pathum Thani, 12120 Thailand, Jaitrong W. , Yamane Sk. ,   Haruyama-chô 1054-1, Kagoshima-shi, 899-2704 Japan, Wiwatwitaya D. ,   Department of Forest Biology, Faculty of Forestry, Kasetsart University, Bangkok 10900, Thailand
Published: November 2021

Currently, 16 species of the genus Ooceraea Roger, 1862 are known from the Oriental, Australian and Oceanian realms, but no identified species have ever been recorded from Thailand. Here Ooceraea siamensis sp. n. is described from Thailand based on the worker and dealate queen. The new species is most similar to O. biroi (Forel, 1907), a species widely distributed across tropical and subtropical regions of the world, but can be distinguished from the latter by postpetiole slightly longer than broad in dorsal view (clearly shorter than broad in O. biroi), by foveae on first gastral tergite and sternite denser and coarser (weak in O. biroi), and by smaller size (head width in new species 0.33–0.38 mm while in O. biroi 0.46–0.49 mm). The type series of the new species was collected from a colony in soil and partly in a coconut seed. Ooceraea duadridentata Yamada, Luong et Eguchi, 2018 is recorded from Thailand for the first time.
New data on distribution of Mycodrosophila poecilogastra (Loew, 1874) (Diptera: Drosophilidae) in Russia
Authors:   N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Vavilov Str. 26, Moscow, 119991, Russia, Gornostaev N.G. , Kulikov A M. ,   N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Vavilov Str. 26, Moscow, 119991, Russia
Published: November 2021

The Transpalaearctic species Mycodrosophila poecilogastra is recorded for the first time from South Siberia and the Central Federal District of Russia. Consequently, a check-list of Drosophilidae of Tuva includes 30 species in eight genera and a list of Moscow City apparently consists of about 40 species.
The “Inside-outside” Sign
Authors: Haridass Shoban , Keshava Shyamkumar N.
Published: November 2021

We describe a radiological sign, “inside-outside sign,” observed during the cannulation of an expandable contrast-filled tubular structure in the human body. In this optical illusion, a catheter or guidewire appears to be outside the lumen when it is inside the lumen in reality. Knowing this rare optical illusion is essential to avoid mistaking it for a catheter or guidewire outside the lumen.
Carpal boss: An uncommon cause of dorsal wrist mass and chronic pain in children. A case report
Authors: Turazza Florencia , Masquijo Javier
Published: November 2021

Pain referred to the wrist joint, is a common affection among the pediatric and adolescent population, either due to acute injury or chronic stress. Even though the most common cause of a wrist mass associated with chronic pain in this patient population is a ganglion cyst, other pathologies should also be considered. We report an uncommon case of a 10-year-old girl with a carpal boss that was treated with surgery after non-operative measures failed to achieve symptom resolution. The diagnosis was established based on clinical examination and imaging findings. Although rare in the skeletally immature population, carpal boss should be considered as a differential diagnosis in a pediatric-adolescent patient with a dorsal wrist mass and chronic pain. The purpose of the present study was to describe the presentation and anatomical findings in our patient, that differ from the cases reported to date, as well as to review treatment options of this condition in the pediatric population.
Correlation between epicardial fat thickness with intima–media thickness and ankle–brachial index in patients with metabolic syndrome
Authors: ARANA-PAZOS KARLA C. , NARVAEZRIVERA JORGE L. , MACEDA-SERRANO ALBERTO , BENITEZ-MALDONADO DANIEL R. , RUBIO-GUERRA ALBERTO FRANCISCO
Published: November 2021

Background

An increase in epicardial fat thickness (EFT) has been associated with increased cardiovascular risk and the development of atherosclerosis. Transthoracic echo-cardiography provides a reliable measurement of EFT. We evaluated the relationship of EFT with carotid intima–media thickness (CIMT) and ankle–brachial index (ABI), in patients with metabolic syndrome.

Methods

We assessed 80 patients with metabolic syndrome who underwent echocardiography; EFT was measured by two cardiologists. The CIMT (B-mode colour imaging of extracranial carotid arteries using high-resolution ultrasound) was also measured by a certified ultrasonographer, and ABI was measured by the main researcher.

Results

We did not find any correlation between ABI with EFT (r=0.0103, p=0.93) or with CIMT (r=–0.1625, p=0.15). However, we found a significant correlation between EFT and CIMT (r=0.2718, r2=0.074, p=0.015). When we evaluated the risk for a CIMT >0.9 mm in patients with an EFT >3 mm, we found a statistically significant association (p=0.039). Interestingly, only 1 patient with an EFT <3 mm had a CIMT >0.9 mm.

Conclusion

We found that the EFT correlates with CIMT in patients with metabolic syndrome, which explains, at least in part, the higher risk of atherosclerosis in them. Measurement of EFT should be part of the cardiovascular risk evaluation in patients with metabolic syndrome.
Prediction of stature from long bones versus hand and foot measurements: A comparative study of the Kolhapur population
Authors: KARMALKAR ARUN S. , NIKAM VASUDHA R.
Published: November 2021

Background

Estimation of stature is usually done by measurement of the long bones. Although hand and foot dimensions are useful in predicting stature, they are population-specific.

Methods

We compared the accuracy of predicting stature by hand and foot dimensions, with long bone (tibia and ulna) lengths, and developed a stature predictive regression formula from the parameters used for the sample population in Kolhapur. We recorded hand and foot measurements and long bone measurements of 1000 consenting participants 18–50 years of age using a stadiometer for height and an anthropometric rod compass for other measurements. Correlation between the variables and stature was determined using Pearson’s correlation analysis (p<0.05). A multiple linear regression formula was derived for the prediction of stature.

Results

A positive correlation was observed between mean stature and foot length (r=0.67, p<0.05), tibia (r=0.66, p<0.05), ulna (r= 0.75, p<0.05) and hand length (r=0.69 left, r=0.72 right, p<0.05). There was no correlation between foot breadth and stature. Multiple linear regression analysis of hand and foot dimensions returned R2=62.96 and standard error of estimate 4.689 with comparable computed and experimental measurements.

Conclusion

The dimensions of the hand and foot can be used to predict stature. The formula derived from the multiple regression analysis incorporating hand and foot dimensions is a good fit to estimate stature in the study population.
Computational studies of the rotors aerodynamic characteristics of multirotor drones
Authors: Kosushkin K. G. , Kritsky B. S. , Mirgazov R. M.
Published: November 2021

The article presents the results of computational studies of aerodynamic characteristics for unmanned lift-generating multi-rotor drones of various configurations. The distinctive features of rotors flow were characterized. The rotor interaction was evaluated. The computations were based on the nonlinear rotor blade vortex theory in a non-stationary arrangement. The combinations of four, eight (four coaxial) and fourteen two-bladed rotors at velocity V = 100, 150, 200 km/h were considered. Semi-empirical methods were employed to select the rotor angles of attack, rotation speed, blade installation angles and geometric parameters at the given take-off weight for each combination of rotors and flight airspeed. The computations showed that for a four-rotor lift-generating design (quad-rotor), two rotors installed downstream, depending on the velocity due to the mutual effect, have values of the thrust coefficients ≈10...20% less than those of the rotors located upstream. For a coaxial quad-copter, the effect of the upper front rotor on the upper rear rotor is similar to the effect of the front rotors on the rear ones in a four-rotor lift-generating design. The effect of the upper front rotor on the lower rear rotor does not vary in terms of the average thrust value, and variations are only local in nature. The interaction of other rotors is identical to that of the four-rotor version. A fourteen-rotor lift-generating multi-rotor drone has a complex flow pattern, which generates deviance in the thrust coefficients variation with respect to time. Depending on the mode and rotors location, the average rotor thrust coefficient can vary approximately twice. The computations showed that with the similar geometric parameters and kinematics characteristics, rotors thrust is substantially subject to variation, which causes destabilizing moments to a significant degree without additional control input. Thrust pulsations and, respectively, vibrations grow in intensity as the flight airspeed increases. Probably, the right choice of the rotor configuration and the automatic control system can counterbalance thrust surge by so-called "phasing", i.e. selecting an initial azimuth angle for each rotor.
Analisis Perbandingan Model Gates, Ackoff & Sasieni, dan Friedman dalam Simulasi Strategi Penawaran Tender Proyek Peningkatan Jalan di Kota Bandung
Authors: Hidayat Felix , Ramdhan Huzein Muhammad , Jayadi Muchammad Sarwono Purwa
Published: November 2021

Menentukan harga penawaran yang penting bagi kontraktor dalam mengikuti tender proyek konstruksi. Oleh karena itu, penelitian ini melakukan penelitian mengenai beberapa model strategi penawaran untuk mendapatkan mark up beserta probabilitas menang. Diantaranya dipilih model Gates, Ackoff & Sasieni, dan Friedman. Penelitian ini menggunakan metode purposive sampling dengan sampel data proyek peningkatan jalan yang diambil dari laman LPSE kota Bandung tahun 2015-2017 sejumlah 116 data. 86 data digunakan untuk analisis model Gates, Ackoff & Sasieni, dan Friedman, kemudian 30 data disisihkan untuk uji validitas. Dari penelitian ini didapatkan grafik mark up vs. Probabilitas menang dari masing-masing model yang dapat digunakan oleh kontraktor sebagai acuan dalam menetapkan harga penawaran. Model Gates menghasilkan nilai mark up optimum untuk distribusi normal berganda, normal tunggal, dan diskrit berganda secara berurutan sebesar 6%, 7%, dan 6%. Model Ackoff & Sasieni menghasilkan nilai mark up optimum untuk distribusi normal berganda, normal tunggal, dan diskrit berganda secara berurutan sebesar 6%, 6%, dan 6%. Model Friedman menghasilkan nilai mark up optimum untuk distribusi normal berganda, normal tunggal, dan diskrit berganda secara berurutan sebesar 3%, 3%, dan 2%. Dari hasil tersebut dapat disimpulkan bahwa model Friedman menghasilkan harga penawaran terendah, namun pesimis dalam memberikan nilai mark up berdasarkan uji validitas.
Perbandingan Kurva S-N dalam Menentukan Umur Kelelahan Struktur
Authors: Arianta Arianta , Pardede Frengki H. , Fransisko Fransisko
Published: November 2021

Struktur anjungan lepas pantai merupakan infrastruktur yang menyokong proses pengeboran minyak di lepas pantai. Sebagian besar struktur anjungan lepas pantai di Indonesia berdiri sejak tahun 1971. Faktor utama masih beroperasi anjungan lepas pantai adalah terkait dengan kebutuhan masyarakat akan minyak bumi. Oleh karena itu, perlu menjadi perhatian khusus agar struktur anjungan lepas pantai dapat beroperasi dengan aman. Analisis kelelahan (fatigue) struktur akan memberika estimasi umur kelelahan struktur, yang mana dapat dijadikan acuan dalam melakukan pencegahan terhadap kegagalan struktur. American Petroleum Institute (API) mengeluarkan dua jenis kurva S-N dalam penentuan umur kelelahan struktur yaitu API X-X’ dan WJT (Welded Joint). Kurva S-N WJT merupakan kruva S-N baru yang dikeluarkan oleh API pada tahun 2014. Dengan adanya kurva S-N terbaru, untuk struktur anjungan lepas pantai tua (sejak tahun 1973) yang masih beroperasi sampai saat ini diperlukan penyesuaian dalam menentukan umur kelelahan. Penelitian ini akan membandingkan analisis kelelahan menggunakan kedua grafik tersebut. Berdasarkan hasil penelitian diperoleh kurva S-N WJ menghasilkan umur kelelahan yang lebih kecil dibandingkan dengan kurva S-N API X. Secara persentase rentang perbedaan hasilnya adalah 11%-79%, hal ini bergantung pada lokasi dan elevasi komponen struktur.
Nonverbal Communication Reconstruction on Facebook
Authors: Candrasari Yuli
Published: November 2021

Facebook provides users comfort in communicating even though they cannot see expressions or any other nonverbal signs, which have been an essential factor in supporting face-to-face communication. Therefore, this research is necessary because the absence of nonverbal communication, especially facial expression, touching, and gesture, renders the communication process between individuals ineffective and uncomfortable, as it was when people first used email to communicate via the internet. Through the study of Computer-Mediated Communication (CMC) perspectives, nonverbal communication, Social Presence Theory and Lack of Social Context Cues theory, this paper will discuss forms of nonverbal communication in the digital era. This study is based on research conducted by researchers using the netnography method and carried out through literature studies. The research was conducted on the Muslim community Bening Society on Facebook because the communication between them is very intense, as required in netnography. The loss of nonverbal communication in interpersonal communication does not, in fact, reduce netizens’ comfort in communicating and interacting. The emergence of digital emoticons and nonverbals is a substitute for nonverbal communication because digital emoticon and nonverbal functions in mediated interpersonal communication are the same as nonverbal communication.
LA APLICACIÓN DE LA LÓGICA JURÍDICA EN LA TEORÍA DEL CASO Y LA LITIGACIÓN ORAL CIVIL
Authors:   UNIVERSIDAD CATOLICA DE SANTA MARIA, AREQUIPA-PERU, Cárdenas Mendoza Diego Ali , Uyen Vargas Diana Fernanda ,   UNIVERSIDAD CATOLICA DE SANTA MARIA, AREQUIPA-PERU, Ramírez Cueva Gelber ,   UNIVERSIDAD CATOLICA DE SANTA MARIA, AREQUIPA-PERU
Published: November 2021

El presente artículo abordará en un inicio sobre la inserción de la litigación oral en los actuales procesos civiles, al amparo del actual Código Procesal Civil, así como también realizar un análisis crítico de la viabilidad y beneficios que brinda esta nueva forma de conducción del proceso, sin desnaturalizar el sistema procesal actual. Asimismo, se abordará el campo de la teoría del caso como acto preparatorio procesal, a fin de arribar a la construcción de este mismo acto, teniendo en observancia la importancia de la lógica jurídica en la elaboración de la teoría del caso, así como también en las técnicas de litigación y la gran influencia de esta misma -lógica jurídica- en la inminente decisión del magistrado. Finalmente, los autores arribaremos a una reflexión final a raíz de los temas expuestos sobre la importancia de la lógica jurídica, no solo para la teoría del caso, sino que, esta se hace extensiva a todos los actos postulatorios a fin de revestir de certeza la tesis ofrecida, esto, dentro de un Estado Constitucional de Derecho. Palabras clave: Derecho Procesal – Litigación Oral – Teoría del caso – Lógica Jurídica – Sentido Común – Demanda.
DETERMINACIÓN DEL RIESGO DE MORTALIDAD UTILIZANDO EL SCORE GRACE EN PACIENTES CON SÍNDROME CORONARIO AGUDO, AREQUIPA 2021
Authors:   Hospital Nacional Carlos Alberto Seguin Escobedo, Arequipa-Perú, Rojas Durand José M. , Nuñez Zevallos Gladys E. ,   Universidad Católica de Santa María, Arequipa-Perú, Nuñez Zevallos Mercedes H. ,   Universidad Nacional de San Agustín, Arequipa-Perú
Published: November 2021

La presente investigación tiene como objetivo determinar el riesgo de mortalidad de pacientes de la población arequipeña que acudió Hospital Nacional Carlos Alberto Seguin Escobedo (HNCASE) usando el score GRACE y hallar la relación del sexo con el resultado de obtener un riesgo alto del score. El estudio fue diseñado con carácter descriptivo correlacional y transversal, para la recolección de datos se acudió a los departamentos de estadística y cardiología del HNCASE, se elaboró una base de datos en el programa Excel 2019, utilizando como herramienta el score GRACE, un score validado al nivel internacional, se calculó el riesgo de muerte de los pacientes con SCA. Con el mismo programa, se elaboraron tablas de frecuencias y promedios para elaborar el informe y, para relacionar el riesgo alto del score GRACE con el sexo de los pacientes, se usó la prueba estadística del Chi Cuadrado. No se consideró a la angina estable ni a la de Prinzmetal en este estudio. Se registraron 234 casos de SCA entre Infartos y Angina Inestable. Varones 76.5%, Mujeres 23.5%. La edad media de mujeres fue de 73 y de varones 67. Los casos más presentados fueron de Infarto agudo de miocardio sin elevación del segmento ST (IAMNSTE) 154 (67%) seguido de Angina inestable 44 casos (18%) e Infarto agudo de miocardio con elevación del segmento ST (IAMSTE) 36 casos (15%). La mayoría de casos tuvieron un score GRACE con riesgo Alto (59% en todos los casos de SCA y 66% en los casos de Infarto Agudo de Miocardio) No hubo diferencia en el número de atenciones realizadas de casos de SCA antes de la pandemia por SARSCOV2 vs. durante la pandemia. Los fallecidos fueron 22 (9.4%). En este estudio se encontró una relación significativa entre el sexo y la probabilidad de obtener un score GRACE con riesgo ALTO de mortalidad, estando en la población arequipeña las mujeres más propensas a obtener un puntaje ALTO a diferencia de los varones. Se concluye que muchos de los resultados obtenidos se parecen a los que se encontraron en estudios hechos en España y Cuba. Se recomienda utilizar un score validado al nivel internacional para determinar el riesgo de mortalidad y así dar un tratamiento ideal, pero no se debe dejar de lado el criterio médico. Palabras clave: Síndrome coronario agudo, Población Arequipeña, score GRACE, riesgo de mortalidad.
RIESGO DE SARCOPENIA SEGÚN LA ESCALA SARC-F EN EL ADULTO MAYOR DE UN CENTRO GERIÁTRICO AREQUIPA – 2021
Authors:   Universidad Católica de Santa María, Arequipa-Perú, Flores Barrios Jessil , Núñez Zevallos Gladys E. ,   Universidad Católica de Santa María, Arequipa-Perú, Nuñez Zevallos Mercedes H. ,   Universidad Nacional de San Agustín, Arequipa-Perú
Published: November 2021

La presente investigación tiene como objetivo determinar el riesgo de Sarcopenia según la escala SARC-F en los adultos mayores de un centro geriátrico Arequipa 2021. Se trata de un estudio observacional, descriptivo y transversal. Se utilizo un cuestionario con la escala SARC-F con un puntaje mayor e igual a 4 para la detección de riesgo de sarcopenia y datos sociodemográficos. Se realizo la medición de peso, talla, IMC, circunferencia de pantorrilla con un punto de corte de menor a 31 cm para la circunferencia de pantorrilla disminuida en los adultos mayores que cumplieron con los criterios de inclusión. Posteriormente se realizó el estudio estadístico y análisis descriptivo. Se obtuvo una muestra de 72 personas, el 61.1% eran del género femenino y 38.9% del género masculino, la edad prevalente es del grupo etario 75-79 años, el 51.4%, el riesgo de sarcopenia se relaciona con el IMC (p=0.032), y con la circunferencia de pantorrilla (p=.018) presentan riesgo de sarcopenia. Se concluye que la prevalencia de sarcopenia según la escala SARC-F fue elevada de un centro geriátrico Arequipa-2021. En base a la edad, género y al estado civil no se presentó una diferencia estadística significativa. De acuerdo a las características antropométricas se encontró una mayor prevalencia de IMC normal y sobrepeso, seguido de obesidad y en menor cantidad bajo peso en los que presentaban riesgo de sarcopenia presentando diferencia estadística significativa. En relación a la circunferencia de pantorrilla se encontró un mayor riesgo de sarcopenia en los que presentaban una circunferencia disminuida, presentando una diferencia estadística significativa. Palabras clave: Adulto mayor, sarcopenia, SARC-F
Evaluate the compliance of perioperative practices of the patients with the enhanced recovery after surgery protocols
Authors: Cigerci Yeliz , Celebi Serife
Published: November 2021

The Enhanced Recovery after Surgery (ERAS) protocol is a multimodal and evidence-based medical practice developed to define the concept of perioperative interventions to improve postoperative outcomes. The protocol consists of a number of elements implemented in the pre-, intra - and post-operative periods. This study aimed to evaluate the compliance of perioperative practices with the ERAS protocols in patients undergoing surgical intervention. In this descriptive and prospective study, 405 patients who underwent surgery in the General Surgery Clinic of a University Hospital created a sample of the study. In the study, where no intervention was made to the patients included in the study, the compliance of routine perioperative practices in the clinic offered to patients undergoing surgery to the protocol was evaluated using the questionnaire prepared in this direction. Procedures such as, in the preoperative period, providing verbal information to all the patients and giving antibiotic prophylaxis to 98.5% of the patients, in the intraoperative period, preferring the smallest possible surgical incision, and, in the postoperative period, using the paracetamol (99.5%) as the first choice for analgesia were compatible with the ERAS protocols. Procedures such as, in the preoperative period, not providing oral carbohydrate to any of the patients and keeping the fasting period longer period (10.91 ± 4.79 hours), in the intraoperative period, preferring anesthetic agents that are effective for a long time, and not perform the necessary practices to ensure normothermia in any of the patients, and, in the postoperative period, not starting the oral nutrition early and using urinary catheterization for 87.7% of the patients were not compatible with the ERAS protocols. As a result of the research, it was determined that the routine perioperative applications in the clinic did not sufficiently comply with the ERAS protocol.
Linguo-Stylistic Means Prevailing in the Presentation of the Horror Atmosphere in Short Stories by Edgar A. Poe and Mykola Hohol
Authors: Dolgusheva Olga
Published: November 2021

The paper addresses the issue of stylistic devices and textual means of creating an atmosphere of horror in the emotive prose of Edgar Poe and Mykola Hohol. The annotated paper is acute as little scholarly attention has been paid to the linguistic matter of presenting the category of horror by both writers while the literary perspective of academic studies of Е.Poe’s and M.Hohol’s writings has evidenced a number of researches, comparative ones including.

The category of horror acquires a number of poetic manifestations with both authors: within the set of characters, space and atmosphere designing etc. Edgar Poe as well as Mykola Hohol resorts to various stylistic devices to render the nuances of the horrific atmosphere. On having conducted the research, the author arrives at the conclusion that epithets and metaphors bear the greatest significance and quantity in the narratives of both men of letters since the stories contain abundance of descriptive passages. They include the description of interior and exterior designs of the dwellings, landscapes etc. The mentioned devices are also attributed with symbolic connotation assigning additional meanings and implications alluding to national philosophies and imagery. The discordance in presenting the mood of horror is observed in the way E. Poe and M Hohol evolve the development of the atmosphere as well as in the use of foreshadowing device and color tropes.
Communicative phenomenon of the old Ukrainian miracle play “Oleksiy, the man of God”
Authors: Moskalchuk Hanna
Published: November 2021

The subject of this research focuses on the communicative and pragmatic structure of dramatic texts of the 17–18th centuries. The aim of this article is to analyse the miracle play “Oleksiy, the Man of God” (Alexius, the Man of God) as a communicative act. The method of semantic-stylistic analysis was used to elicit the semantic and stylistic peculiarities of the language means and patterns of their use. Context and situational analysis, as well as interpretative analysis, were used to identify textual elements with additional pragmatic meaning; the analysis of actual material was conducted in line with the principle of historicism, i.e. taking into account the correspondence of the linguistic and lingual stylistic system of the texts to the time of their creation.

The Results of the Study. The dramatic text holds a specific place in the system of artistic communication, since it stands as a meaningful reproduction of the communicative process. A key feature of any dramatic text is dramatis personae that are put at the beginning of the play and who, as a rule, can be related to real people in real situations. The old Ukrainian baroque drama mainly takes the forms of drama mystery play and miracle play. The character system in “Oleksiy, the Man of God” reflects the social structure of society at that time, and the characters’ speech correlates with the speech of real people and stands as its textual embodiment. The process of author’s describing the real picture of the world is the main author’s intention, which coincides with the illocution in the dramatic text. The article analyses the communicative past and communicative future of certain characters. The analysis concentrates on the stylistic means used by the author to enhance the impact on the addressee and create the intended communicative effect, in particular wordplay techniques. The role of extratextual elements that help decode the author’s idea and achieve a perlocutionary effect has been determined. The prospects for further research include studying pragmatic and stylistic function of the phenomenon of variability of the speech genres in old Ukrainian texts of the 17–18th centuries.
An Efficient Mapping Tool Development for University Campuses: The Case Study of Süleyman Demirel University
Authors: BATAR Mustafa
Published: November 2021

The main purpose of this study is to design and develop “Süleyman Demirel University Campus Maps system (SDU Campus Maps)” with geographic information systems in order to create a campus information system. By the contribution of SDU Campus Maps, which is planned to be carried out, directions will be provided from one point to another within the university, and it will be convenient for visitors who do not know about Süleyman Demirel University campus. With this idea, it is based on the preparation of the environment so that directions can be made using the SDU campus map. With the help of this study, it has been aimed to provide contribution to the literature of both geographic information systems and mapping.
USE OF GEOSTATISTICAL MODELS IN THE SPACE-TEMPORAL EVALUATION OF WATER QUALITY OF AN AMAZONIAN HYDROELECTRIC RESERVOIR
Authors: Silva Thiago de Melo e , Pereira Simone de Fátima Pinheiro , Freitas Kellen Heloizy Garcia , De Sousa Pedro Moreira , Silva Cléber Silva e , Santos Davis Castro dos , Rocha Ronaldo Magno , De Souza Alan Marcel Fernandes , Nogueira Daniel Pinheiro
Published: November 2021

The Tucuruí Hydro-Power Complex reservoir, Pará State, Amazon Region-Brazil, as well as other reservoirs is subject to natural alterations and anthropogenic activities which in turn affect the environmental balance. The aim of this work was to verify if geostatistical models can be used in the spatial-temporal evaluation of water quality in reservoirs. The Surfer 13® software was used to interpolate the spatial distribution of data, in two years of surface water physicochemical parameters were evaluated in sixteen sampling stations. The results of the isotopic maps showed low concentrations of DO at station C1 in the Intermediate Period 2 (summer-winter), high concentration of COD at station MP in the Intermediate Period 1 (winter-summer) and increased acidity at stations C1 and C2 in summer, suggesting that the relationship between the Tucuruí Hydro-Power Complex and farming activities in the region cause impacts on the aquatic ecosystem along the reservoir.
PENGEMBANGAN DESTINASI WISATA PANTAI NAPAK TILAS DESA LEMBAR SELATAN PADA MASA PANDEMIC COVID-19
Authors: Suprianti Baiq Novi , Istagina Dina , Halimiaty Siti , Buhari Nurliah
Published: November 2021

Desa Lembar Selatan merupakan salah satu desa yang ada di Kecamatan Lembar, Kabupaten Lombok Barat. Selain memiliki potensi wisata hutan mangrove juga memiliki potensi pantai yang dapat dikembangkan sebagai objek wisata Salah satu pantai tersebut adalah Pantai Napak Tilas. Pantai ini merupakan pantai berpasir dan mempunyai pemandangan yang unik. Tujuan pengabdian ini adalah melakukan pengembangan dan penataan destinasi wisata Pantai Napak Tilas. Kegiatan pengabdian ini dilakukan melalui program Kuliah Keja Nyata (KKN) selama 30 hari pada bulan Juni – Juli 2021. Kegiatan yang dilakukan dimulai dengan survei potensi wisata, penataan, dan pengembangan wisata. Survei dilakukan dengan cara observasi dan wawancara dengan pemerintah desa. Penataan dan pengembangan wisata dilakukan dengan  membuat program kerja sesuai dengan permasalahan yang ditemukan saat survei. Seluruh program yang direncanakan untuk mengembangkan Pantai Napak Tilas seperti kegiatan bersih pantai, pembuatan sarana pendukung dan promosi melalui media sosial dapat terlaksana dengan baik berkat kerjasama antara mahasiswa, pemerintah desa, dan masyarakat. Pelaksanaan kegiatan mengikuti protokol Covid-19. Namun demikian, masalah sampah kiriman menjadi tantangan besar terbesar dalam pengelolaan Pantai Napak Tilas sehingga diperlukan kerjasama lebih lanjut antara masyarakat, pemerintah desa, dan pihak swasta untuk menanganinya.
Existing perception of Patient safety among health personnel in operating room at CHICH (Children Hospital & Institute of Child Health, Lahore.
Authors: Bhatti Muhammad Naveed , Zohra Rubab , Talat Nabila , Ihsan Muhammad
Published: November 2021

Background: Patient Safety is the key concept of every healthcare setup worldwide as it depicts the perception of health care personnel about patient safety and quality of care delivered to patients. The World Health Organization along with other major organizations has taken initiatives to deal with patient safety challenges. Objective: To assess the existing perception of patient safety among health personnel in operating rooms of tertiary care hospital in Pakistan. Study Design: Cross Sectional study. Setting: Children Hospital & Institute of Child Health Lahore. Period: July 2018 to December 2018. Material & Method: Participants were selected through proportionate simple random sampling. The WHO patient safety survey was used to assess perception of patient safety culture. Data was collected after taking consent. The data was entered in SPSS version 25 and analyzed by it. “Composite positive response rate” for the various dimensions were calculated. Reliability was checked by Cronabach alpha which was more than 0.7 (70%). Results: The overall response rate in the study was 100%. Average composite positive response percentage was 65.17% and it varied among different cadres of HCPs ranged from 51% to 88%. The dimensions “Personal attitude to Patient safety” and “Personal influence over safety” showed highest positive response among all cadres (88 % and 67 %) respectively. composite Positive percent response about patient safety culture varied among different cadres of health personnel, nurses showed highest positive response percentage of 71.2%. Conclusion: Safety culture assessment is a useful tool for evaluation of patient safety interventions, measuring organization’s safety culture and raising awareness. WHO patient safety study tool showed the average positive response rate of 65.17% but the dimension “Safety of health care system”, and “Error and patient safety” have least positive response which shifts the focus to organizational conditions that lead to adverse events and patient harm in healthcare organizations. The result also highlighted areas that required improvement, as perceived by health care workers.
Cyanotic congenital heart disease: Impact on growth and endocrine functions.
Authors: Arshad Muhammad Sohail , Khan Waqas Imran , Zulqarnain Arif , Anwar-ul-Haq Hafiz Muhammad , Adnan Mudasser
Published: November 2021

Objective: To find out the impact of Cyanotic Congenital Heart Disease (CCHD) on growth and endocrine functions at a tertiary care child healthcare facility of South Punjab. Study Design: Case Control study. Setting: Department of Pediatric Cardiology and Department of Pediatric Endocrinology, Institute of Child’s Health (ICH), Multan, Pakistan. Period: December 2018 to March 2020. Material & Methods: During the study period, a total of 53 cases of Echocardiography confirmed CCHD were registered. Along with 53 cases, 50 controls during the study period were also enrolled. Height, weight, body mass index (BMI) along with hormonal and biochemical laboratory investigations were done. Results: There was no significant difference between gender and age among cases and controls (p value>0.05). Most common diagnosis of CCHD among cases, 24 (45.3%) were Tetralogy of Fallot (TOF) followed by 9 (17.0%) transposition of the great arteries (TGA) with Ventricular Septal Defect (VSD) with Pulmonary Stenosis (PS). Mean weight of CCHD cases was significantly lower in comparison to controls (21.19+6.24 kg vs. 26.48+8.1 kg, p value=0.0003). Blood glucose was significantly lower among cases in comparison to controls (77.58+14.58 mg/dl vs. 87.25+11.82 mg/dl, p value=0.0004). No significant difference was found in between cases and controls in terms of various hormone levels studied (p value>0.05) except Insulin-like Growth Factor-1 (IGF-1) levels (p value<0.0001). Conclusion: Children with cyanotic congenital heart disease seem to have negative effects on nutrition and growth. Change in pituitary-adrenal axis is suspected while pituitary-thyroid axis seemed to be working fine among CCHD cases. Serum glucose and IGF-1 levels were significantly decreased among CCHD cases.
Risk factors of severe pneumonia among children: A hospital based case control study in Lahore, Pakistan.
Authors: Jabeen Chanda , Mushtaq Muhammad Hassan , Umbreen Gulshan
Published: November 2021

Objective: To identify the risk factors of severe pneumonia among children 2-59 months of age in a Tertiary Care Hospital Lahore, Pakistan. Study Design: Case Control study. Setting: Mayo Hospital Lahore. Period: December 2016 to March 2017. Material & Methods: Cases were 162. Controls were selected in 1:1. Sample size was 162 cases and 162 controls. Purposive sampling technique was used. Informed consent taken from each participant before collection of data. Structured questionnaire was used. Data was analyzed through SPSS 20.0. Chi square and binary logistic regression was applied. Results: Low socio economic conditions, low maternal and parental education, contact with the member having upper respiratory tract infection, having contact with member suffering from URTI, hospitalization due to diarrheal illness and being underweight were found strongly associated with severe pneumonia (having odds ratios more than 1) among children 2-59 months of ages in this study. Conclusion: Poverty, illiteracy of parents and having contact with member having respiratory infection and underweight are potential risk factors of severe pneumonia.
Psychosocial impairment in children with Celiac disease.
Authors: Afzal Erum , Sheikh Aslam , Khosa Ghazi Khan , Noor Komal
Published: November 2021

Objective: To determine the frequency of psychosocial impairment in patients with celiac disease. Study Design: Descriptive Cross Sectional study. Setting: Children Hospital Complex and Institute of Child Health, (CHICH) Multan. Period: August 2019 to August 2020. Material & Methods: A total number of 177 patients having age 4-16 years with diagnosis of CD were included in this study. In children with CD depressive illness were assessed by using Pediatric symptoms checklist (PSC) form and this PSC form was filled by asking questions from parents then filling of form by doctor. Outcome variable was calculated on the basis of Pediatric symptoms checklist (PSC), whether patient has psychosocial illness or not. Results: Mean age of patients was 8.91±3.50 years. Mean duration of celiac disease of patients was 4.27±2.00 months. There were 135 (76.27%) female patients and 42 (23.73%) male patients. Mean serum anti-tissue transglutaminase IgA (tTG-IgA) level of patients was 122.73±24.31 µg/ml. The socioeconomic status of 115 (64.97%) patients was poor, 31 (17.51%) was middle, 18 (10.17%) patient was upper middle and 13 (7.34%) patients was high. Psychosocial illness was present in 35 (19.77%) patients. Conclusion: Psychosocial illness was diagnosed in 19.77% children having CD. So the children with celiac disease should be monitored for symptoms of anxiety and depression and a thorough counselling of the children to reduce the risk of psychosocial illness.
Fulminant hepatic failure during pregnancy.
Authors: Nazish Zahra , Inayatullah Muhammad , Zahra Fatima Tu
Published: November 2021

Objective: To observe clinical characteristics, etiology and maternal outcome in fulminant hepatic failure during pregnancy. Study Design: Descriptive Case Series. Setting: Department of Medicine, Nishtar Hospital Multan. Period: January 2013 to December 2017. Material & Methods: Twenty nine consecutive patients with fulminant hepatic failure during pregnancy were included in the study. Results: Mean age of patients was 27.06±6.92 years. 65.51% patients were from urban areas. Mean duration of gestation was 24.80±6.03 weeks. Jaundice and altered consciousness were observed in 100% cases, pallor in 79.31%, hepatomegaly in 20.68%, flapping tremors in 10.34%, ascites in 10.34% and splenomegaly in 6.89% cases. Complications observed were cerebral edema in 44.82%, renal failure in 24.13%, bleeding in 20.68% and hypoglycemia in 3.44%. Most common cause was acute hepatitis E (75.86%) followed by hepatitis B (13.79%) and hepatitis A (3.44%). No cause was found in 6.89% cases. Overall maternal mortality was 37.93% and fetal mortality was 72.41%. In 17.24% cases pregnancy was terminated therapeutically, 44.82% cases had spontaneous expulsion and in 37.93 % cases pregnancy continued. Maternal mortality was highest (45.45%) in patients who remained pregnant as compared to 20% when pregnancy was terminated therapeutically. Conclusion: Jaundice and altered conscious level is the most common clinical presentation. Hepatitis E is the most common cause of FHF in pregnancy. Maternal mortality in FHF during pregnancy is very high.
Frequency of number of roots and root canals of maxillary first premolar teeth.
Authors: Khattak Munawar Aziz , Arbab Sana , Shah Syed Amjad
Published: November 2021

Objective: To determine the frequency of the number of roots and root canals in a sample of 250 extracted maxillary first premolar teeth of patients visiting Peshawar Dental College and Hospital Khyber Pakhtunkhwa. Study Design: Cross Sectional. Setting: Department of Oral Biology, Peshawar Dental College and Hospital Khyber Pakhtunkhwa. Period: April 2016 to December 2016. Material & Methods: A total of 250 extracted human maxillary first premolars were collected from the Department of Oral & Maxillofacial Surgery, Peshawar Dental College, and Hospital Khyber Pakhtunkhwa. All teeth were visually inspected to count the number of roots. Subsequently, the access cavity was prepared, and pulp extirpated from each tooth. Endodontic explorer was used to locating the canal orifice(s) at the pulp chamber floor. Later the root canal orifices were injected with India ink to stain the canals. After that roots of teeth were sectioned at different levels to note down the number of canals. Data were analyzed using SPSS version 19. The statistical significance of the variations from mean values was considered significant if the p-value was less than 0.05. Results: Out of 250 maxillary first premolar teeth, 44.8% had one root, 40.4% had two separate and 12.8% had two fused roots. Three roots were seen in 2.0% teeth. Two root canals were present in the vast majority (70.4%), whereas one and three root canals were seen in 27.6% and 2.0% teeth, respectively. The correlation between the number of roots and root canals of maxillary first premolar teeth was highly significant. Conclusions: There was a high frequency of maxillary first premolars with two roots and two root canals.