bluuebunny/crossref_metadata_2025 huggingface dataset:
Elevated RIF1 Participates in the Epigenetic Abnormalities of Zygotes by Regulating Histone Modifications on MuERV-L in Obese Mice
Authors: Huang Jiliang , Ru Gaizhen , Sun Jiajia , Sun Luying , Li Zhiling
Published: November 2021

Background
Maternal obesity impairs embryonic developmental potential and has significantly increases metabolic risks in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnormalities is still poorly understood.
Methods
We induced an obesity model in female mice by high-fat diet (HFD) feeding. The effects of a HFD on the developmental potential of oocytes and embryos, metabolic phenotype, and epigenetic modifications were investigated. The efficacy of metformin administration was assessed. Finally, the regulatory pathway of epigenetic remodeling during zygotic genome activation (ZGA) was explored.
Results
Maternal HFD significantly impaired glucose tolerance in F0 mice, and increased the risk of metabolic disorders in F1 mice. Maternal HFD also decreased embryonic developmental potential, increased ROS and γH2AX, and reduced the mitochondrial membrane potential (MMP) within oocytes, causing high levels of oxidative stress damage and DNA damage. Starting with this clue, we observed significantly increased RIF1 and shortened telomeres in obese mice. Significant abnormal DNA methylation and histone modification remodeling were observed during ZGA in obese mice, which may be coregulated by RIF1 and the ZGA marker gene MuERV-L. Metformin treatment reduced RIF1, and partially improved ZGA activation status by rescuing epigenetic modification remodeling in oocytes and preimplantation embryos of obese mice. RIF1 knockdown experiments by Trim-Away methods showed that RIF1 degradation altered the H3K4me3 and H3K9me3 enrichment and then triggered the MuERV-L transcriptional activation. Moreover, the ChIP-seq data analysis of RIF1 knockout also showed that RIF1 mediates the transcriptional regulation of MuERV-L by changing the enrichment of H3K4me3 and H3K9me3 rather than DNA methylation.
Conclusion
Elevated RIF1 in oocytes caused by maternal obesity may mediate abnormal embryonic epigenetic remodeling and elevated metabolic risk in offspring by regulating histone modifications on MuERV-L. Metformin treatment can partially rescue the abnormal epigenetic remodeling and prevent epigenetic transmission of maternal metabolic abnormalities.
Biomechanical Evaluation of Reconstruction of Calcar Femorale Structure for Femoral Neck Fractures: A Comparative Finite Element Analysis
Authors: Gao Zhi-Hao , Ma Jian-Xiong , Wang Ying , Lu Bin , Bai Hao-Hao , Sun Lei , Jin Hong-Zhen , Zhang Zi-Jian , Ma Xin-Long
Published: November 2021

The authors have requested that this preprint be removed from Research Square.
Biomimetic Manganese-Eumelanin Nanocomposites for Combined Hyperthermia-Immunotherapy Against Prostate Cancer
Authors: Liu Yu , Shang Wenting , Liu Heng , Hui Hui , Wu Jun , Zhang Wei , Gao Pengli , Guo Kunxiong , Guo Yanli , Tian Jie
Published: November 2021

Pro-tumoral and immunosuppressive M2-like tumor-associated macrophages (TAMs) contribute to tumor progression and distal metastasis. However, current TAMs-modulating therapeutic strategies often encounter challenges including insufficient immune activation, weak antigen presentation ability and unsatisfactory antitumor immune performance. Herein, cyclic RGD peptide functionalized and manganese doped eumelanin-like nanocomposites (RMnMels) were designed for combined hyperthermia-immunotherapy against PC3 prostate cancer. The RMnMels could promote M2-to-M1 macrophage repolarization via scavenging reactive oxygen species and remodel the tumor immunosuppressive microenvironment (TIME). Following near-infrared light irradiation, RMnMels-mediated local hyperthermia not only could destroy tumor cells directly through thermal ablation, but also elicit the release of damage associated molecular patterns and tumor-associated antigens, which could act as effective immunological stimulators to provoke robust tumor immunogenicity and strong antitumor immune responses. The results showed that RMnMels could effectively scavenge reactive oxygen species and promote M2-to-M1 macrophage repolarization both in vitro and in vivo. Synergistically enhanced anti-tumor therapeutic efficacy was achieved following single administration of RMnMels plus single round of laser irradiation, evidenced by decreased primary tumor sizes and decreased number of distant liver metastatic nodules. The as-developed RMnMels may represent a simple and high-performance therapeutic nanoplatform for immunomodulation and enhanced antitumor immune responses.
Ethnobotanical Study of Cowpea (Vigna Unguiculata (L.) Walp.) in Senegal
Authors: Sarr Awa , Bodian Amy , Gueye Mame Codou , Gueye Badara , Kanfani Ghislain , Diatta Cyril , Bougma Ali Lardia , Diop Elisabeth A.M.C. , Cissé Ndiaga , Diouf Diaga , Leclerc Christian
Published: November 2021

Cowpea (Vigna unguiculata) plays a key role in family farming systems in Senegal. It makes an essential contribution to economic, nutritional and food security. Although it is crucial, little is known about how farmers classify the diversity of local varieties or about the social practices associated with them. The aim of this study is to characterize the farming practices associated with growing cowpea in Senegal. Surveys were conducted involving 335 rural farmers living in 37 villages, spread across seven regions that produce cowpea. An average of ten farmers were randomly selected in each village. The results reveal that cowpea is a key feature of cropping systems in the studied area. Our findings highlight the high diversity of local cowpea varieties with 59 local names inventoried. In 75% of cases, the name refers to the seed’s morphology or color. Cowpea production is more diverse in Diourbel and Louga and less diverse in the south. More than half the farmers (57%) acquired their cowpea seeds (early, semi-early and late varieties) outside their village, either from markets, seed suppliers or NGOs. This new understanding of farmers’ expertise in the management of cowpea and its local variability will help to valorise local diversity in breeding programmes.
Coarse-Grained Modeling of The Calcium, Sodium, Magnesium And Potassium Cations Interacting With Proteins
Authors: Lipska Agnieszka Gabriela , Antoniak Anna Maria , Wesołowski Patryk , Warszawski Alan , Samsonov Sergey A , Sieradzan Adam Kazimierz
Published: November 2021

Metal ions play important biological roles e.g.: activation or deactivation of enzymatic reactions and signal transduction. Moreover, they can stabilize protein structure, or even be actively involved in the protein folding process. Therefore, accurate treatment of the ions is crucial to model and investigate biological phenomena properly. In this work the coarse-grained UNRES (UNited RESidue) force field was extended to include the interactions between proteins and four alkali or alkaline earth metal cations of biological significance, i.e. calcium, magnesium, sodium and potassium. Additionally, chloride anions were introduced as counter-ions. Parameters were derived from all-atom simulations and incorporate water in an implicit manner. The new force field was tested on the set of the proteins and was able to reproduce the ion-binding preferences.
Geographical inequalities in COVID-19 mortality: a scoping review protocol
Authors: Bambra Clare , McGowan Victoria J
Published: November 2021

Objective

The objective of this scoping review is to understand what is known in relation to geographical inequalities in COVID-19 mortality.
Introduction:

COVID-19 has occurred against a backdrop of existing social and economic inequalities in health. The impact of the pandemic has been examined across various intersections of health inequalities such as age, gender, ethnicity, and occupation. However, spatial inequalities have been less explored. Therefore, this review aims to identify and synthesise what is known on geographical inequalities in COVID-19 mortality globally.
Inclusion criteria:

Following standard scoping review methodology the inclusion criteria will be guided by Population, Concept, Context (PCC). Population: children and adults (all ages); Concept: Area-level inequalities in COVID-19 mortality; Context: any country, at any level (neighbourhood, town, city, municipality, region). Any published, peer-reviewed study written in English that focuses on all three elements of the PCC inclusion criteria will be included.
Methods

Searches will be conducted in (host sites given in parentheses) Medline (Ovid), Embase (Ovid), Science Citation Index Expanded and Social Science Citation Index (Web of Science) and limited to dates ranging from 1st January 2020 to December 31st 2021. Reference lists of all relevant papers will be searched for additional studies. All titles and abstracts will be screened in Rayyan. Primary studies focusing on COVID-19 mortality rates disaggregated by any measure of area-level deprivation will be selected for full text review. Data relating to study design, population, location, outcomes, and results by deprivation will be extracted using standardised extraction forms. Identified papers meeting the inclusion criteria will be tabulated, synthesised thematically and a narrative constructed to describe the evidence base of geographical inequalities in COVID-19 mortality.
Spatio-temporal analysis of hydropower projects with terrestrial environmentally sensitive areas of Nepal
Authors: Ghimire Hemant R
Published: November 2021

Hydropower project construction is increasing, which can affect the terrestrial environment. Hydropower projects located in environmentally sensitive areas have higher environmental impacts, so I analyzed the spatiotemporal interaction between hydropower project locations and terrestrial environmentally sensitive areas of Nepal to visualize the probable environmental impacts. Most of the existing projects lie on the hill; however, future projects are moving northward. Among the 12 eco-regions of Nepal, hydropower projects are located in 10 eco-regions. Hydropower projects were found to interact with more than half of the biodiverse areas of the country (28 out of 45), and more than five thousand megawatts of hydropower projects are located completely inside these biodiverse areas. The study suggests that the interaction between hydropower projects and environmentally sensitive areas might increase in the future. Hydropower projects should avoid environmentally sensitive areas such as biodiverse areas and protected areas as much as possible to minimize the impacts. Rapid hydropower development is a necessity in countries such as Nepal, so further studies on the effects of hydropower projects on environmentally sensitive areas as well as improvement of the quality of the environmental assessment of the projects are necessary for environmentally friendly development.
Risk Factors for Postoperative Recurrence of Ovarian Endometrioma in Young Women
Authors: Xin Xing , Song Xiaochen , Zhao Xinyang , WU Shanshan , Hao Xinyao , Song Aixin , Meng Zifan , Qi Jiarui , Tan Jichun
Published: November 2021

Purpose

Ovarian endometroma seriously affects women's health, and is susceptible to recurrence after surgery. However, only a few studies have been conducted to asses the risk factors for postoperative recurrence of ovarian endometrioma in young women, and no risk factors associated with recurrence have been found. The purpose of this study is to analyse the risk factors for postoperative recurrence of ovarian endometrioma in young women, and to provide data support for postoperative follow-up of high-risk groups.
Materials and Methods

We retrospectively analysed 196 young women who underwent ovarian endometrioma resection in Peking Union Medical College Hospital and Shengjing Hospital from January 2008 to January 2018 and were followed-up for at least 3 years postoperatively. The patients were divided into a recurrence group or a non-recurrence group. Their preoperative histories, laboratory indexes, intraoperative manifestations, and follow-up symptoms were analysed.
Results

The cumulative recurrence rate of ovarian endometrioma in young women 3 and 5 years after surgery was 8.0%, and 20.3%, respectively. Univariate analysis showed significant differences in cancer antigen-125 levels (hazard ratio [HR]: 3.207, 95% confidence interval [CI]: 1.126–9.135, P = 0.029), the revised American Fertility Society (rAFS) disease stage (HR: 4.588, 95%CI: 1.422–14.805, P = 0.011), postoperative pregnancy (HR: 0.28, 95%CI: 0.109–0.723, P = 0.008), and postoperative dysmenorrhoea (HR: 2.465, 95%CI :1.320–4.604, P = 0.005) between the two groups. Cox multivariate proportional risk analysis showed that rAFS disease stage (HR:3.783, 95%CI: 1.162–12.311, P = 0.027) and postoperative dysmenorrhoea (HR: 2.291, 95%CI :1.222–4.296, P = 0.01) were risk factors for postoperative recurrence of ovarian endometrioma, whereas postoperative pregnancy (HR: 0.361, 95%CI: 0.138–0.944, P = 0.038) was a protective factor for postoperative recurrence. There was no significant correlation between recurrence of ovarian endometrioma and age at surgery, age at the time of menarche, body mass index, duration of dysmenorrhoea, degree of dysmenorrhoea, genital malformation, surgical approach, maximum diameter of the cyst, and postoperative medication.
Conclusion

rAFS disease stage and postoperative dysmenorrhoea are risk factors for the recurrence of ovarian endometrioma during long-term follow-up, whereas postoperative pregnancy is a protective factor.
What is the Impact of CSN5 on the Prognosis of Digestive System Cancers: A Systematic Review and Meta-Analysis
Authors: Guo Yonghua , Gao Meng , Yao Ye , Li Jinghua , Chen Xi , Wang Xingxing , Chen Zhang , Yuan Yufeng , Ma Weijie
Published: November 2021

Background: Despite the understanding of COP9 signalosome subunit 5 (CSN5) in tumor genesis, there is no conclusive evidence on CSN5 value to predict digestive system tumor patients' survival and prognosis. The article was performed to evaluate the impact of CSN5 expression levels on survival consequence and clinicopathological parameters of digestive system neoplasm patients.Methods: A comprehensive search was conducted through four databases. We utilized Hazard Ratio (HR) with a 95% confidence interval (CI) to evaluate the prognostic value of CSN5 in overall survival (OS) and recurrence free survival (RFS). We estimated the connection between CSN5 and clinicopathological parameters based on Odds Ratio (OR) with a corresponding 95% CI. Results: The meta-analysis contained 22 studies, involving 2,193 patients diagnosed with digestive system tumor. High CSN5 expression level was indicated to predict poorer OS (HR = 2.28, 95% CI: 1.71–3.03; p < 0.00001). Additionally, high CSN5 was correlated with worse invasion depth (OR = 0.49, 95% CI: 0.25-0.96, p = 0.04), positive lymphatic metastasis (OR = 0.28, 95% CI: 0.16-0.47, p = 0.00001), positive distant metastasis (OR = 0.32, 95% CI: 0.13-0.76, p = 0.01) and poorer differentiation degree (OR = 0.34, 95% CI: 0.19-0.60, p = 0.0003). However, we could not find a correlation between CSN5 expression and age, gender, tumor stage, tumor size or vascular invasion. Furthermore, no significant publication bias was detected.Conclusion: This meta-analysis demonstrated that the overexpression of CSN5 level could foresee poorer OS in digestive system cancer patients. Additionally, CSN5 level was related to tumor invasion depth, lymphatic metastasis, distant metastasis and differentiation degree.
Identification of Key Iron Metabolism-Related Long Non-Coding Rnas in Hepatocellular Carcinoma Based on Bioinformatics Analysis
Authors: Chen Yu
Published: November 2021

The present study explored the regulatory mechanisms and functional roles of iron metabolism-related long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC) and their potential impact on prognosis of HCC patients. RNA-seq data and clinical information of HCC samples and normal samples were downloaded from The Cancer Genome Atlas (TCGA) database and International Cancer Genome Consortium (ICGC) portal. Iron metabolism-related genes were downloaded from Reactome database and AmiGo2 database. Differential expression and correlation analysis were performed to identify iron metabolism-related differentially expressed lncRNAs (DElncRNAs). Moreover, Kaplan-Meier (KM) survival and receiver operating characteristic (ROC) analysis were used to screen the possible prognostic and diagnostic biomarkers of HCC. A total of 20 differentially expressed and iron metabolism-related genes (DEIMRG) were identified by overlapping 3746 differentially expressed genes (DEGs) and 86 IMRGs. Next, ARHGAP11B, LINC00205, LINC00261 and SNHG12 were screened through Univariate Cox regression. Kaplan-Meier survival curves indicated that ARHGAP11B, LINC00205, LINC00261 and SNHG12 were related to overall survival (OS) in HCC patient in TCGA database. ARHGAP11B, LINC00205 and LINC00261 were finally identified as prognostic DEIMRGs related with OS of HCC patients after validate the survival results in ICGC portal. ARHGAP11B, LINC00205 and LINC00261 all achieved an AUC value of >0.80 in ROC curve analysis. Furthermore, LINC00205 was identified as independently prognostic factor by multivariate Cox analysis combined with clinicopathological factors. Moreover, a ceRNA network including 25 DEmRNAs, 15 DEmiRNA and 3 DElncRNAs was successfully constructed, based on prognostic DElncRNAs and key target miRNAs and mRNAs of them predicted by starBase database and miRwalk. The PPI network illustrated that CDC25A, CHEK1, CCNE2 and ANLN proteins interact more with other proteins. In the present study, we identified iron metabolism related LINC00205 as a prognostic and diagnostic biomarker and constructed a metabolism-related ceRNA network, which may contribute to the treatment of HCC.
An Integrative Multi-Omics Analysis Based on Liquid-Liquid Phase Separation Delineates Distinct Subtypes of Lower-Grade Glioma and Identifies a Prognostic Signature
Authors: Zheng Jianglin , Wu Zhipeng , Qiu Yue , Wang Xuan , Jiang Xiaobing
Published: November 2021

Background: Emerging evidences have indicated that the aberrant liquid-liquid phase separation (LLPS) leads to the dysfunction of biomolecular condensates, thereby contributing to the tumorigenesis and progression. Nevertheless, it remains unclear whether or how the LLPS of specific molecules affects the prognosis and tumor immune microenvironment (TIME) of patients with lower-grade glioma (LGG).Methods: We integrated the transcriptome information of 3585 LLPS-related genes to comprehensively evaluate the LLPS patterns of 423 patients with LGG in The Cancer Genome Atlas (TCGA) cohort. Then, we systematically demonstrated the differences among four LLPS subtypes based on multi-omics analyses. In addition, we constructed the LLPS-related prognostic risk score (LPRS) for individualized integrative assessment. Results: Based on the expression profiles of 85 scaffolds, 355 regulators, and 3145 clients in LGG, we identified four LLPS subtypes, namely LS1, LS2, LS3 and LS4. We confirmed that there were significant differences in prognosis, clinicopathological features, cancer hallmarks, genomic alterations, TIME patterns and immunotherapeutic responses among four LLPS subtypes. In addition, a prognostic signature called LPRS was constructed for individualized integrative assessment. LPRS exhibited a robust predictive capacity for prognosis of LGG patients in multiple cohorts. Moreover, LPRS was found to be correlated with clinicopathological features, cancer hallmarks, genomic alterations and TIME patterns of LGG patients. The predictive power of LPRS in response to immune checkpoint inhibitor (ICI) therapy was also prominent.Conclusions: This study provided a novel classification of LGG patients based on LLPS. The constructed LPRS might facilitate individualized prognosis prediction and better immunotherapy options for LGG patients.
Enhancing the Insecticidal Potential of Baculovirus by Overexpressing the Mammalian Β-Galactosyl Binding Protein Galectin-1
Authors: Lin Chia-Yang , Lin Yu-Chun , Wu YuehLung , Huang Rong-Nan
Published: November 2021

Developing bio-pesticides is an important area of research in agriculture for which viruses are an essential tool. Infection by entomological pathogenic viruses kills agricultural pests, and viral progenies are disseminated to infect more pests, eventually achieving long-term pest control in the field. Of the current virus-based pest control models, Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the most studied. AcMNPV belongs to the family Baculoviridae and can infect many lepidopterans. Although AcMNPV has been previously demonstrated as a potential pest-control tool, its long virus infection cycle has made field application challenging. To overcome this hurdle, we generated a recombinant baculovirus that can express mammalian galectin-1, which is a-galactoside-binding protein that binds to the peritrophic matrix in the midgut of pest lepidopterans and induces perforation of the membrane. Galectin-1 has been shown to affect immune responses in mammals, including humans, but to our knowledge, the effect of galectin-1 on insect immune systems has not been previously reported. Hosts infected with this recombinant virus exhibited reduced appetite and died sooner in both laboratory and small-scale field studies, suggesting that the overexpression of galectin-1 can more efficiently eliminate pest hosts. In addition to disrupting the integrity of the peritrophic matrix, the immune system of hosts infected with recombinant baculovirus carrying the galectin-1 gene was suppressed, making hosts more vulnerable to secondary infection. These results demonstrated that the potential of baculovirus for pest control can be improved by using a recombinant baculovirus that overexpresses mammalian galectin-1 in hosts.
Convergence of Energy Carbon Emission Efficiency: Evidence From Manufacturing Sub-sectors in China
Authors: Liu Dongdong
Published: November 2021

With China's economy entering the stage of high-quality development, manufacturing energy carbon emission efficiency has become the focus of academic attention. Based on the panel data of China's manufacturing sub-sectors, this paper measures and analyzes the evolution trend of manufacturing energy carbon emission and its efficiency. On this basis, this paper uses coefficient of variation and convergence model to test the convergence of manufacturing energy carbon emission efficiency. The results show that China’s manufacturing energy carbon emissions and its efficiency show an increasing trend. The coal was the main source of manufacturing energy carbon emissions. The manufacturing energy carbon emission efficiency does not exist σ convergence, but exists β convergence, and its convergence exists industry heterogeneity. The manufacturing energy carbon emission efficiency exits scale effect and technology effect, but not the effect of opening to the outside world and institutional effect, and its effect exists industry heterogeneity. By reducing carbon emissions, adopting differentiated policies, adjusting the industry scale, and enhancing the industry technology intensity, China's manufacturing can improve the energy carbon emissions efficiency and promote high-quality economic development.
Simulation and Optimization of Airport Rainwater Drainage System at Different Control Measures
Authors: Peng Jing , Yu Lei , Zhong Xiang , Dong Tiansong
Published: November 2021

The impervious area of the airport is high, which leads to the deterioration of the water environment and frequent waterlogging disasters. The construction of sponge airport has become an important and arduous task in the new era of civil aviation design industry in China. In order to compare the effects of different control measures at different scenarios, take the airport along China's southeast coast as an example, three scenarios were designed in this study (Scenario 1: no LID facilities and other measures; Scenario 2: two pump stations were setting; Scenario 3: both LID facilities and pump stations). Three simulation models under LID facilities and other measures were developed using SWMM with return period of 5a. The simulation results at different scenarios were compared, the number and the best opening scheme of pumps for each reservoir are finally obtained. The results of Scenario 3 show that the full-flow duration of nodes in the study area is greatly shortened. The decrease of full-flow duration of J1, J2 and J3 was 1.2, 0.8 and 0.5 hours respectively, with reduction rates of 40%, 53.3% and 28.6% respectively. The rainfall peak flows both the first and the second were reduced in this scenario, and the reduction rates were 10.68% and 12.78% respectively. However, the reduction effect of the third peak is poor with the further increase of rainfall intensity. The reduction rate of the total inflow and peak flow of rainwater buckets and permeable pavement is better than that of vegetative swale. The results of this study can provide the reference for the design of sponge airport and the airport flood control management.
Improvement of physical activity was significantly reduced serum hepatocyte growth factor levels in a general population: 10-year prospective study
Authors: Sakaue Akiko , Adachi Hisashi , Enomoto Mika , Fukami Ako , Nohara Yume , Morikawa Nagisa , Yamamoto Maki , Satoh Hiromi , Fukumoto Yoshihiro
Published: November 2021

Background: We have previously reported that hepatocyte growth factor (HGF) levels were significantly associated with insulin resistance or components of the metabolic syndrome. However, it has been unknown how physical activity (PA) affects HGF levels after a long-term follow-up.
Aims: Our aim was to clarify the association between PA changes and HGF levels /cerebro-cardiovascular disease (CVD) development during 10 years follow-up period in a community-dwelling Japanese general population.
Methods: Of 1,320 subjects who received a health check-up examination in Tanushimaru town in 1999, 903 subjects (341 males and 562 females) were enrolled, who received the examination both in 1999 and 2009. We evaluated their PA levels by Baecke questionnaire in 1999 and evaluated their PA levels by a simple questionnaire in 2009. We measured the serum HGF levels by ELISA method in 1999 and 2009. We divided into four physical activity groups such as stable low PA, increased PA, decreased PA, and stable high PA. Using these questionnaires, we compared their PA and HGF levels in 10 years.
Results: A significant inverse association was found between PA changes and serum HGF levels in 10 years after adjustment for age and sex. The serum HGF levels of increased PA group were significantly lower than stable low PA (p=0.038), and the former group showed the reduced CVD development compared to the latter group after adjustment for age and sex (p=0.012).
Conclusions: Our data demonstrated that improvement of PA levels was associated with reduced HGF levels and CVD development.
Electrospinning of Liquefied Banana Stem Residue in Conjugation with Hydroxyapatite Nanocrystals: Towards New Scaffolds for Bone Tissue Engineering
Authors: Sadat-Shojai Mehdi , Asadnia Milad
Published: November 2021

Electrospun fibers have high structural similarity to the extracellular matrix (ECM) of natural bone. Some researchers have tried to fabricate cellulose nanofibers using electrospinning method, although the fabricated fibers usually exhibited a non-uniform texture. Moreover, the fabricated mats always suffer from low biological, mechanical and structural properties. Thus, the objective of this study was first to produce a naturally occurring cellulose from banana pseudo-stem through the combination of liquefaction and bleaching processes. The native cellulose was then tried to electrospun in order to determine how a systematic approach based on a Taguchi L9 orthogonal array can be used to fabricate a defect-free fibrous mat. Finally, the electrospun cellulose mats incorporated with hydroxyapatite (HA) nanoparticles were fabricated to generate a new fibrous nanocomposite with enhanced biological and mechanical characteristics. The results revealed that among the electrospinning parameters, cellulose concentration of solution and applied voltage had the greatest effect on the morphology of the fibers. The morphological characterization of the fibrous nanocomposites showed that fibrous cellulose/HA mats had a uniform fiber texture without any significant bead, splashing or particle agglomeration. According to the mechanical tests, the samples containing the higher concentration of HA had a significantly higher elastic modulus and tensile strength. The results obtained from bioactivity analysis indicated an interesting morphological transformation into a flake-like structure which confirmed the high bioactivity of the scaffolds. Accordingly, encapsulation of HA nanoparticles inside the cellulose in the fibrous form can be promising for bone regeneration applications.
Instability Attenuation And Bifurcation Studies of A Non-Ideal Rotor Involving Time Delayed Feedback
Authors: Dasgupta Sovan Sundar
Published: November 2021

In non-ideal vibratory system, the excitation is a nonlinear function of system response. The dynamic behavior of such system is often characterized by an energy source with limited power. The study of instability phenomena in non-ideal rotor driven through a non-ideal energy source is of considerable current interest. The non-ideal rotor system often gets destabilized on exceeding a critical input power near the resonance. This kind of instability is termed as Sommerfeld effect marked with nonlinear jump phenomena. This paper investigates the attenuation of nonlinear jump phenomena and numerical study of bifurcations of a non-ideal unbalanced rotor system with internal damping using time delayed feedback via active magnetic bearings. The results show that the time delay indeed plays a critical role on the suppression of the jump phenomena. Following, some new insights are also revealed through a numerical study of saddle node, Hopf and trans-critical bifurcations with time delay as a bifurcation parameter. The transient analysis confirms the results obtained analytically through the steady-state consideration.
Using Geographically Weighted Regression to Assess the Relationship Between Weather and Sociodemographic Indicators and COVID-19 Infection in Iraq
Authors: Rasul Azad , Ibrahim Saad
Published: November 2021

The impact of COVID-19 is still being recognised due to increased research, demand for the communication of uncertainties and evidence based information to help decision makers to design appropriate mitigation policies overtime. Weather and sociodemographic indicators are important to comprehensively understand rapid spread of the disease at a given spatial scale. The spatial pattern in the occurrence of disease may hint at the mechanisms that produce the disease, hence spatial analysis is very useful in studying the causes of a disease. This study evaluates the influence of weather variables, sociodemographic characteristics and their corresponding records of COVID-19 in Iraq cities. The assessments of these relationships were based on R0 estimated from the time series data of COVID-19 infections, and by using geographically weighted regression (GWR) and linear regression modelling. Global estimates of these relationships from the linear regressions are generally poor. On the contrary, the results derived from the GWR show spatially varying patterns. The lag7 of weather variables performed better compared to other lags. Among weather variables, increasing wind speed leads to risen COVID-19 infection. Population density is one of the sociodemographic characteristics that contributes to higher COVID-19 infection. COVID-19 infections, on the other hand, decreased in cities with a good health index and access to piped water. The findings of this study are therefore of great value to policy makers to design appropriate measures to reduce COVID-19 infection in Iraq and elsewhere.
Recyclable Ag/TiO2@PDMS Coated Cotton Fabric with Visible-Light Photocatalytic for Efficient Water Purification
Authors: Zhang Meiling , Jiang Shuai , Han Fuyi , Chen Heping , Wang Ni , Liu Liying , Liu Lifang
Published: November 2021

Multifunctional materials for water purification have attracted great attention due to the increased water pollution problems. However, fabricating the low-cost and recyclable separation material is still a challenge. Herein, we developed an Ag/TiO2@PDMS coated cotton fabric with self-clean ability, high flux, superior visible-light photocatalysts ability, and recyclability via the “powder + glue” strategy. The composites exhibit superhydrophobic (water contact angle 157°), and high separation efficiency. The separation efficiency of 20 times of repeated use remains 16322 Lm−2h−1 and the degradation rate of methylene blue (MB) remains almost no change. The high oil purification, catalytic property, excellent stability in harsh condition and recyclability enables the material as a satisfactory candidate for water purification.
Što slike znaju?
Authors: Purgar Krešimir
Published: November 2021

U radu nastojimo rasvijetliti postupke koje je potrebno primijeniti utoliko, ukoliko želimo ustanoviti posljedice koje nastupaju kada se sedimenti značenja u slikama talože jedan na drugi stvarajući specifičnu
slikovnu epistemologiju. Također ćemo ukazati na neke interdisciplinarne mehanizme analize slikovnog materijala, poput »kulturalne simptomatologije« i »kulturalne triangulacije«, a dat ćemo i
tipologiju kulturalno-povijesnih sedimentacija slikovnog značenja koje ovdje nazivamo aproprijacija. Zaključit ćemo da Bredekampova teorija slikovnih činova, jednako kao i Mitchellove slike kao »žudeći objekti« te Beltingovo razumijevanje ljudskog tijela kao »medija slike« upućuju na to da je interakcija čovjeka i slike ogledalo njegove vlastite želje za proizvodnjom paralelnog svijeta koji on doživljava stvarnim, ali, kako je to objasnio Lambert Wiesing, ne mora u njemu sudjelovati jer slika omogućava različite oblike participacije ili izostanka iz participacije u stvarnom događaju. Ono što slike »znaju« jest specifična
posljedica činjenice da neživi slikovni objekti mogu posjedovati pamćenje, ali – za razliku od umjetne inteligencije – svoje znanje mogu aktivirati samo u recipročnom komunikacijskom odnosu s ljudima.
Dogma i stvaralaštvo: prilog vrednovanju Grlićeve kritike dogmatizma
Authors: Kavarić Mandić Slađana
Published: November 2021

Rad se bavi temeljnim karakteristikama dogmatskog mišljenja, posebno imajući u vidu odnos prema stvaralačkoj biti čovjeka. Problematizirajući
razvoj čovjeka i njegove (samo) percepcije u uvjetima poželjne jednoznačnosti i limitirane slobode, rad ukazuje na neophodnost stalnog prevladavanja danih mogućnosti, te istaknuti značaj slobodarskih, antidogmatskih praksi u cilju ozbiljenja humanističke filozofije. Referirajući na temeljne pretpostavke filozofije Danka Grlića, rad ispituje konsekvence političke instrumentizacije Marxa, upozorava na jednodimenzionalnost dogmatskog mišljenja i naglašava antidogmatsku prirodu izvornog marksizma.
Samopredstavljanje na društvenim mrežama
Authors: Perkov Ivan , Šarić Petar
Published: November 2021

U radu se predstavlja sociološki teorijski okvir za proučavanje samopredstavljanja na društvenim mrežama. Rad se teorijski oslanja na sociološke klasike E. Goffmana i M. Castellsa, ali i na radove drugih područja znanosti u kojima su se istraživali samopredstavljanje i društvene mreže kao društveni fenomeni. U prvom se dijelu rada nudi kontekstualni okvir razvoja informacijskih tehnologija i rasta broja korisnika društvenih mreža, a iznose se i terminološka pojašnjenja. Potom se analiziraju sociološki pristupi fenomenima društvenih mreža i samopredstavljanja u okviru dramaturškog pristupa. Dovodi se u pitanje prostorno-vremenski okvir kojeg donosi pojava interneta i u kontekstu se
toga okvira analizira samopredstavljanje. Analizira se i pojam izložbene stranice koji označava novi oblik nastupa na platformama društvenih mreža, vremenski status suvremenog oblika samopredstavljanja na društvenim mrežama, te asinkroni karakter komunikacije koji to samopredstavljanje podrazumijeva.
THE PREEMINENCE OF CUSTOMARY LAW IN ARAB SOCIETIES AN ANTHROPOLOGY STUDY IN RURAL AREAS
Authors:   Research Professor, Faculty of Law and Political Sciences, University of Saida., Abdennour Benslimane
Published: November 2021

The prevalence of customary law within Arab societies, and in particular in the area of â€‹â€‹water sharing and the organization of agro-pastoral lands has created a kind of conflict between customary legality and the positive law of the modern state, this the latter having become incapable of establishing its laws on the rural areas in which the tribes settle, and which have codified standards and have become familiar with modern laws enacted by the state.In order to preserve the social and economic balance in the Arab countries, the authorities in power were forced to promulgate laws and decrees in accordance with the customs and traditions of their peoples, in particular those related to agro-pastoral activity. Therefore, it can be said that the aim of the modern state is to place custom in a legal form respected by social groups.
LEVEL OF SATISFACTION WITH COVID-19 VACCINE AFTER GETTING JABS AMONG THE GENERALPOPULATION IN GURGAON, HARYANA
Authors:   M.Sc. Nursing, Amity College of Nursing, Amity University Haryana., Jyoti Gyan , Kumar Yadav Arun ,   M.sc ASLP, Amity University Haryana., Kumari Ritu ,   M.Sc. Nursing, R R College of Nursing, Gurgaon, Haryana., Coudhary Bhattacharjee Ruma ,   M.sc nursing ,Senior Executive (Nursing education), Artemis Hospital Gurgaon.
Published: November 2021

Coronavirus disease (COVID-19) is an infectious disease caused Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).To bring this pandemic to an end, only Vaccines are effective interventions that can reduce the high burden of this diseases globally.The purpose of the study to assess the level of satisfaction among the general population after getting the jab of covid -19 vaccine and regarding the vaccination services. A quantitative approach, cross sectional e- survey was conducted on 332 general population through snow ball sampling among general population of Gurgaonaged 18â€‰years and above from 25th May 2021 to 30th July 2021. The result showed that 70.8% of general populationwere dissatisfied after getting the jab of COVID 19 vaccine. The results indicate a high rate of dissatisfaction after getting jab of the COVID-19 vaccine among general population. This result may vary with large sample size.
COMPLEMENTARY ANALYTICAL TECHNIQUES PAPER, THIN-LAYER, HIDE-POWER, AND COMBINED METHODS FOR CHARACTERIZATIONOF TANNIN IN PLANTS
Authors:   Department of Industries, College of Applied and Industrial Sciences, University of Bahri P.O. Box 13104-Khartoum, Sudan., Haroun Mahdi
Published: November 2021

The polyphenolic compoundsextract rich in gallo-catechol tannins submitted to complementary analytical techniqueswas evaluated. The whole plantspecies screened were of the condensed type except Acacia seyal var. fistuala, Acaciaseyal var. seyal, Casuarina equistifolia, and Pithecellobium dulcewere of mixedhydrolysable-condensed(gallo-catechol) type. The quantitative data indicated that 5 parts (bark) out of 12 species, when extracted, contained more than 10% tannins (oven-dry basis), the level of commercial interest. The catechin numbers indicated that all the studied species contained condensed tannin in varying amounts (0.6-45.7), while the presence of both gallic acid and catechin means that the tannin is of mixed type. Thin-layer and paper chromatography with different solvent systems confirmed the presence of catechin and gallic acid, and showed that tannic acid, fisetin, epicatechin and some unidentified phenolics were present. However, dihydrofisetin and robinetin, which were used as standards, were not detected. Astringency values shows that the Acacia mellifera(0.18), Acacia seyalvar.fistuala(0.18), Pithecellobium dulce (0.15), Acacia senegal (0.14), Acacia farnesiana (0.13), Calotropis procera (0.13)barks could be used in place of A. mearnsii(international commercial tannin materials) (0.16) because the degree of relative astringency or the ability of their tannin to combine with protein is close to that of A. mearnsii in other words these six species can give leather with characteristics comparable with that of A. mearnsii.
FACIAL WOUND ASSESSMENT KIT
Authors:   Assistant Professor and Head of the Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Adil Dehhaze , Rim Labbaci ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Nada-Imane Daghouri ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Otmane Taybi ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Issam Diher ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco., Nour El Imane Ahmar-Rass ,   Resident, Department of Plastic, Reconstructive and Aesthetic Surgery, Center for Burned Patients, CHU Tangier-Tetouan-Al Hoceima, Morocco.
Published: November 2021

Facial wounds are a frequent reason for emergency room visits. The goals of laceration repair are to achieve hemostasis, avoid infection, restore function to the involved tissues, and achieve optimal cosmetic results with minimal scarring. Therefore, these cases are most appropriately managed by plastic surgeons who have a thorough knowledge of anatomy, aesthetic sense, and meticulous expertise in atraumatic tissue manipulation, combined with the surgical skill to repair any structure. You need to know what to do and what not to do : whether to suture or leave open. What local anesthesia to use and how. What equipment to use (and have it available beforehand). Whether to give antibiotic therapy and what kind. How to avoid aesthetic or functional after-effects. Which dressing to use depending on the state of the wound. This article will serve as an aid to wound management and review repair techniques for high-risk areas of the face.
ETUDE DES CARACTERISTIQUES MECANIQUES DE VARIETES DE TUBERCULES DIGNAME, DE PATATE ET DE MANIOC CONSOMMES AU BURKINA FASO
Authors:   Centre National de la Recherche Scientifique et Technologique (CNRST)/ Institut de Recherche en Sciences Appliquees et Technologies (IRSAT)-Departement Mecanisation (DM), 03 BP 7047 Ouagadougou 03, Burkina Faso., Kader Hounsouho Lingani Abdel ,   Universite Joseph KI-ZERBO, Unite de Formation en Sciences Exactes et Appliquees (UFR/SEA), Laboratoire dEnergies Thermiques Renouvelables (L.E.T.RE), 10 BP 13495 Ouagadougou 10, Burkina Faso., Georges Ye Siedouba ,   Centre National de la Recherche Scientifique et Technologique (CNRST)/ Institut de Recherche en Sciences Appliquees et Technologies (IRSAT)-Departement Mecanisation (DM), 03 BP 7047 Ouagadougou 03, Burkina Faso.,   Universite Joseph KI-ZERBO, Unite de Formation en Sciences Exactes et Appliquees (UFR/SEA), Laboratoire dEnergies Thermiques Renouvelables (L.E.T.RE), 10 BP 13495 Ouagadougou 10, Burkina Faso., Kam Sie ,   Universite Joseph KI-ZERBO, Unite de Formation en Sciences Exactes et Appliquees (UFR/SEA), Laboratoire dEnergies Thermiques Renouvelables (L.E.T.RE), 10 BP 13495 Ouagadougou 10, Burkina Faso., Joseph Bathiebo Dieudonne ,   Universite Joseph KI-ZERBO, Unite de Formation en Sciences Exactes et Appliquees (UFR/SEA), Laboratoire dEnergies Thermiques Renouvelables (L.E.T.RE), 10 BP 13495 Ouagadougou 10, Burkina Faso.
Published: November 2021

Lobjectif de cette etude est letude des caracteristiques mecaniques de varietes de tubercules dignames, de patates et de manioc consommes au Burkina Faso. Deux varietes ont ete etudiees par tubercules et les principaux paramÃ¨tres mecaniques etudies sont la resistance Ã la penetration des tubercules et leurs forces maximales de decoupe. Un banc dessai traction compression muni dun capteur de compression dune force maximale de 2000 Newton (N) a ete utilise Ã cet effet.Un outil de decoupe ainsi quune tige ont ete utilises respectivement pour la decoupe des tubercules en tranche et pour leur penetration. Six (06) plages de vitesses (15, 30, 45, 60, 75, 90 mm/s) ont ete utilisees pour la decoupe des tubercules en tranches, et une vitesse de 20 mm/s pour la penetration. Les teneurs en eau moyennes des tubercules etudiees etaient comprises entre 58,8Â±1,8 % et 77,1 Â± 1,8 %. Lanalyse des resultats des tests de durete et de decoupe des tubercules nous ont permis dobtenir leurs forces maximales de penetration qui sont de 145 N pour ligname bÃªtÃª bÃªtÃª, 216 N pour la patate douce fadanga blanche et 391 N pour le manioc kalagÃ¨.Les forces maximales de decoupe sont de 311 N pour ligname gogo, 347 N pour le manioc kalagÃ¨ et 410 N pour la patate douce fadanga blanche. Cette etude nous permet de mieux comprendre les facteurs pouvant affecter lefficacite de decoupe des tubercules. Les donnees de cette etude peuvent Ãªtre dintegrees dans le dimensionnement des motorisations des equipements de transformation post-recolte des tubercules en vue de leur optimisation energetique.
SIMPLE BONE CYST OF THE MANDIBLE: A CASE REPORT AND LITERATURE REVIEW
Authors: Muthuraman Varun
Published: November 2021

Simple bone cyst is a benign pseudo cystic cavity in the bone that is less commonly associated in the maxillofacial region. The other synonyms are traumatic bone cyst or idiopathic bone cyst. These cysts are devoid of an epithelial lining and usually contain straw-colored fluid or is empty. Simple bone cyst is mainly seen in young individuals, frequently during the first and second decade of life. Here we report a case of simple bone cyst of a mandibular anterior region in a 21-year-old patient.
INTRA-CARDIAC THROMBUS IN BEHCETS DISEASE: TWO CASE REPORTS
Authors:   Cardiology Department of the Military Training Hospital of Mohamed V, Rabat, Morocco., Maliki Alaoui A. , Mesmoudi B. ,   Cardiology Department of the Military Training Hospital of Mohamed V, Rabat, Morocco., Amchich Y. ,   Pulmonology Department of the Military Training Hospital of Mohamed V, Rabat, Morocco., Loudeyi N. ,   Cardiology Department of the Military Training Hospital of Mohamed V, Rabat, Morocco., Zaimi A. ,   Cardiology Department of the Military Training Hospital of Mohamed V, Rabat, Morocco., Asfalou I. ,   Cardiology Department of the Military Training Hospital of Mohamed V, Rabat, Morocco., Benyass A. ,   Cardiology Department of the Military Training Hospital of Mohamed V, Rabat, Morocco.
Published: November 2021

Behcets disease (BD) is a multi-systemic inflammatory disorder characterized by a recurrent oral and genital aphthosis associated with multiple organ disorders: ophthalmic, neurological, vascular, and digestive.Cardiac involvement in BD especially Intra-cardiac thrombus (ICT) is extremely rare only 50 cases have been registered worldwide [1-5]. We report a rare case of two patients aged respectively 18-year-old and 50-year-old who are diagnosed with Behcets disease complicated by right-sided heart thrombi extended to the pulmonary artery.