bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of tumor-like multipotent mesenchymal stromal cells in rheumatoid arthritis
Authors: Kiselevskiy M. V. , Anisimova N. Yu. , Chikileva I. O. , Vlasenko R. Ya. , Dolzhikova Yu. I. , Sitdikova S. M. , Senatov F. S. , Yang K. C. , Yang J. C.
Published: November 2018

Multipotent mesenchymal stromal/stem cells (MSCs) are regarded as a stable, safe and easily available source of precursor cells for purposes of regenerative medicine. However, under repeated replication in tissue reparation processes and action of inflammatory mediators, aged MSCs may be transformed and obtain certain tumor-cell characteristics. The present review deals with the MSCs role in pathogenesis of rheumatoid arthritis. High proliferation speed, lack of contact inhibition and invasive growth of transformed MSCs is an important mechanism of cartilage destruction in rheumatoid arthritis.
Toxicological profile of aimpila drug in chronic experiment on rats
Authors: Treshchalin I. D. , Golibrodo V. A. , Treshchalin M. I. , Eremkin N. V. , Tsurkan S. A. , Pereverzeva E. R.
Published: November 2018

Introduction. As a rule, pharmacotherapy of neoplastic diseases is associated with side effects varying degrees of severity. This is determined by the insufficient selective action of antitumor agents and, as a result, high nonspecific toxicity. One way to solve this problem is the development of the targeted drugs, delivered the active agent to the tumor cells. Over the past decades many experimental and clinical studies were undertake, but only few of them have demonstrated clinical efficacy of targeted drugs. This determines the necessity of further search in this direction. Objective: to investigate the toxicity of aimpila, its correlation with dose and reversibility. Materials and methods. Toxicological study of aimpila, developed by Pharmaceutical Scientific Center “PharmAccess” Ltd. (Moscow), was performed in male and female outbred rats. Aimpila is atractyloside alpha-fetoprotein noncovalent complex. Capsule mass of the drug in starch gel was administrated per os at the 1 and 10 therapeutic dose (30 x 0.1 mg/kg or 30 x 1 mg/kg with 24-h interval). Dynamics of body weight, hematological parameters, blood biochemical parameters, electrocardiography and urinalysis were performed for all animals. 5 animals in each group were sacrificed 1 and 30 days post treatment. Results. The results of the study demonstrate that the treatment with aimpila does not produce any changes in examined clinical-labora- tory parameters. Liver, renal, cardio, pancreatic and gastrointestinal toxicity of aimpila have been documented by microscopic pathology observation only in groups of rats, treated with high dose of drug. Histopathological findings of hepatotoxicity were supported by the results of clinical chemistry. Marked elevation of aspartate aminotransferase in serum was found after high dose aimpila treatment. These abnormalities were reversible during a month. Conclusion. The overall result of this study suggests the aimpila formulation has favorable toxicological profiles. Dose dependence and reversibility of toxic effects allows us to recommend it to further advance.
PPROACHES TO THE ASSESSMENT OF MINIMAL RESIDUAL DISEASE IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS IN CONDITIONS OF TARGET THERAPY
Authors: Beznos O. A. , Grivtsova L. Yu. , Popa A. V. , Shervashidze M. A. , Serebryakova I. N. , Tupitsyn N. N.
Published: November 2018

Background. Flow cytometry (FC) algorithms of detection of minimal residual disease (MRD) are well standardized, and approximate to molecular biologic methods. However, besides informative leukemia-associated aberrant immunophenotype, which are selected taking into account a tumor phenotype at diagnostics stage, it is necessary to consider specificity of the provided taget therapy and its influence on a cell. Objective: to offer stable combinations of antigens to identify B-cell precursors in patients on therapy of blinatumomab. Materials and methods. Clinical observation of patient G. 4 years old with B-cell precursors acute lymphoblastic leukemia (ALL) (pre-pre-B immunosubtype), whom after 3 bloks of reinduction therapy, taking into account MRD-positive status, blinatumomab was appointed as a monotherapy. Tumor immunophenotype was characterized in details by FC protocol according to EuroFlow in debute and relapse of the disease. MRD monitoring was provided by 8-color FC taking into account personalized leukemia-associated aberrant immunophenotypes. Results. In patient with B-cell precursors ALL received blinatumomab, the strategy of MRD monitoring was changed. Due to the lack of CD19 expression, identification of B-cell precursors was based on expression of cyCD22 in combination with nuclear TdT and CD10. Conclusion. In case of blinatumomab’s appointment during B-cell precursors ALL therapy, it is necessary to change the strategy of B-cell precursors identification, due to the lack of CD19 expression. Detection of B-cell precursors should be provided by assessment of other pan-B lineage antigens. First of all, it is cyCD22 or cyCD79a in combination with nuclear TdT and CD10, within the limits of nucleated cells of the sample.
Biomarkers of translational medicine
Authors: Osipova T. V. , Bukhman V. M.
Published: November 2018

The development of new medicines is one of the priority areas of translational medicine. A significant role for biomarkers (BM) that assess the safety and efficacy of new drugs. The right choice of BM reduces the time and costs necessary for the development of drugs and transfer them to the clinic. The review is devoted to the analysis of modern scientific literature on the role of previously known and newly discovered BM in translational research. Translational BM (TBM) established during preclinical studies and are applicable at all stages of the study. TBM should have a high sensitivity and specificity, be easily measured in real time in an easily accessible biological fluids, to evaluate the same process in different species of animals (including humans), make it possible to compare the results of clinical trials with preclinical. The main role of the TBM toxicity to predict, identify and monitor the toxicity of drugs at all stages of their study. The international consortium (Predictive Safety Testing Consortium, PSTC) whose main task is the qualification of new TBM toxicity and the search for new, more advanced than existing methods for testing markers, was established. Under PSTC formed 6 working groups, each of which coordinates research for the study and selection of TBM toxicity caused by the administration of drugs in the liver, kidney, heart and blood vessels, skeletal muscle, testes. The first qualified consortium markers were 7 contained in the urine markers for preclinical studies on rats with the goal of establishing early lesions in the kidney induced by drugs. Only a small number of BM used in the study of new drugs, can be translational.
Аffinity properties of plant-made anti-her2 antibodies
Authors: Scherbakov A. I. , Kosobokova E. N. , Pinyugina M. V. , Sheshukova E. V. , Kosorukov V. S.
Published: November 2018

The Her2 receptor is an important target for antitumor therapy in the treatment of breast cancer. Trastuzumab, based on anti-Her2 monoclonal antibodies, is used in clinical practice. Trastuzumab is produced by animal cells culture technology and is quite expensive. We use the technology of production of recombinant antibodies in the plants Nicotiana benthamiana with a high yield of final purified protein. Objective. The aim of following study is a comparison of monoclonal antibodies received via classic cell culture technology and produced in plant biomass. Materials and methods. Recombinant plant-made antibodies were isolated by affinity chromatography from the biomass of N. benthamiana plants agroinfiltrated by vector constructs. Comparison of affinity properties was carried out by immunocytochemical staining of cells and competitive binding using flow cytometry analysis. Results and conclusion. We show that the antibodies expressed in N. benthamiana are equal to those obtained from mammalian cells in binding to Her2 antigen localized on the surface of the SK-BR-3 cells. In the present work it was shown that the plant-made anti-Her2 antibodies do not differ in specific binding with the Her2 antigen, as well as with IV subdomain of the Her2 receptor.
EGFR Tyrosine kinase inhibitors in the treatment of metastases of non-small cell lung cancer in the brain
Authors: Naskhletashvili D. R. , Gorbunova V. A. , Bychkov M. B. , Bekyashev A. Kh. , Karakhan V. B. , Aleshin V. A. , Moskvina E. A.
Published: November 2018

Brain metastases are very common in non-small cell lung cancer. The condition of these patients is complicated and difficult to treat, and adverse reactions following treatment can affect the nervous system, which severely reduces quality of life. In this review we discuss the methods in use from local therapies such as whole brain irradiation, stereotactic radiosurgery and central nervous system surgery to systemic therapy. We also highlight drugs for targeted therapy of non-small lung cancer cells metastasis in the brain that have been effective in the treatment of metastases in central nervous system.
Experimental evaluation of toxic properties of LCTA-2034 by the oral routeof administration
Authors: Treschalin M. I. , Treschalin I. D. , Golibrodo V. A. , Shchekotikhin A. E. , Pereverzeva E. R.
Published: November 2018

Introduction.New antitumor multitarget drug LCTA-2034, obtained in Gause Institute of New Antibiotics, has demonstrated high activity against prognostically significant transplantable mice tumors by the oral application.

Objective.To investigate the toxicological properties of LCTA-2034 by the oral route of administration on rats.

Materials and methods.Toxicological study of LCTA-2034 was performed on 30 male Wistar rats. Drug substance dissolved in potable water. 2 % solution was administrated per os at the 1 and 5 therapeutic dose (15 × 20 mg/kg or 15 × 100 mg/kg with 24-h interval). During the study dynamics of body weight, hematological parameters, blood biochemical parameters, electrocardiography and urinalysis were performed for all animals. Five animals in each group were sacrificed 1 and 30 days post treatment. The internal organs were subjected to histological evaluation.

Results.The results of the study demonstrate that the treatment with low dose of LCTA-2034 does not produce any changes in majority of examined clinical-laboratory parameters with the exception of urinalysis revealed hematuria on day 1 post treatment. Microscopic pathology observation showed structure abnormalities of varying severity in liver, kidneys, heart, stomach, jejunum, ileum, spleen and thymus. Administration of high dose of LCTA-2034 caused mortality of 2 rats in group. The rest of the rats were observed a body weight lag, decrease of total leukocyte and erythrocyte count, hemoglobin and hematocrit level, relative weight of the thymus. Erythrocytes and nitrates were found in urine both on day 1 and on day 30 post treatment. In groups treated with high dose of the drug in addition to the listed above organs damage of the structure of lymph nodes, pancreas, ileum and brain was detected. Conclusion. Revealed toxic properties of LCTA-2034 depended on dose. Multiple administration of 1 therapeutic dose of the drug produces transient toxic effects completely reversible within 30 days.
The betting market over time: overround and surebets in European football
Authors: Gomez-Gonzalez Carlos , Del Corral Julio
Published: November 2018

Sports betting is an important industry that generates billions of euros of revenue in Europe, and attracts the attention of sports economists. The recent entry of new companies could influence the market regarding the prices (overround), and hence, cross-bookmaker arbitrage opportunities. This paper investigates the movements of major betting companies in European football during the period from 2000-2001 to 2016-2017 with respect to these two issues. The results show a continuous decrease in the prices of the odds, which is especially noticeable in the top five leagues. In this line, the number of surebets have increased among major bookmakers in recent years, which offers bettors more possibilities to make a profit.
Does betting experience matter in sequential risk taking in horse race wagering?
Authors: Saastamoinen Jani , Suhonen Niko
Published: November 2018

This paper examines how betting experience is associated with horse race bettors’ sequential risk taking. We use an individual-level data set of 5,217 individual bettors with 167,816 betting-related transactions. Our analyses suggest that inexperienced bettors take on more risk than experienced bettors do after they experience gains. We also find some indication that experienced bettors become more risk averse than inexperienced ones after incurring losses.
Regulation of online gambling
Authors: Fiedler Ingo
Published: November 2018

In most jurisdictions gambling is considered a demerit good that causes negative externalities and requires market interventions. Such interventions are based on (1) consumer protection and public health, (2) crime prevention and public order, and (3) fiscal motives. Despite a relative homogeneity among Western cultures in normative values, a broad variety of regulatory systems for online gambling can be observed, ranging from free markets to licensing systems, state monopolies and prohibitions—even within the same nation state. It is hypothesized that these differences stem from insufficient knowledge of the idiosyncrasies of online gambling rather than from different regulatory goals. A comparative study is thus needed to explore the socioeconomic effects of different regulatory regimes and to educate regulators.
Adecuación del Viaducto Ferroviario de Serín como pasarela peatonal
Authors: Arrieta Berdasco Valentin
Published: November 2018

El proyecto ejecutado recupera un tramo de vía ferroviaria abandonada durante décadas en la parroquia de Serín (Gijón). Parte de dicha vía discurre por un viaducto del siglo XIX que es acondicionado como pasarela peatonal salvando la barrera física que supone la autopista, y que hasta ese momento dificultaba enormemente la conexión entre los distintos barrios. El nuevo objeto arquitectónico se inspira en la configuración del viejo puente, y su diseño se integra en él. Con esta intervención se recupera un elemento patrimonial de gran importancia al mismo tiempo que se proporciona a los vecinos un paso seguro sobre la autopista.
Los legados suntuarios de Juan Rodríguez de Fonseca. El terno de San Isidoro de León
Authors: Teijeira Pablos María Dolores
Published: November 2018

Juan Rodríguez de Fonseca, obispo de varias sedes castellanas y hombre de estado al servicio de la corona en los últimos años del siglo XV y primeros del XVI, fue un importante patrón artístico en los templos de los que fue titular, promoviendo relevantes obras de arquitectura, escultura y pintura en ellos, y regalando, o legando en su testamento, significativas piezas suntuarias, especialmente vestiduras litúrgicas. Como abad de San Isidoro de León legó a esta casa un terno que todavía se conserva y que se estudia ahora por primera vez, como muestra de su interés por el correcto, y esplendoroso, desarrollo del culto en sus iglesias.
Crystal preferred orientation of olivine in mantle xenoliths from Catalonia (NE Spain) Orientación cristalina preferente del olivino en xenolitos mantélicos de Cataluña (NE de España)
Authors: Fernández-Roig M. , Galán G. , Mariani E.
Published: November 2018

Abstract: Mantle xenoliths in Neogene-Quaternary alkaline volcanic rocks from the Catalan Volcanic Zone indicate that ≪anhydrous≫ spinel lherzolites, harzburgites and much subordinate olivine websterites form the lithospheric mantle of NE Iberian Peninsula. Olivine crystal preferred orientation, determined by indexation of electron-backscattered diffraction patterns, provides three types of deformation fabric: a dominant [010]-fiber type in peridotites and websterites equilibrated at high temperature, and subordinate orthorhombic and [100]-fiber types, which appear mostly in porphyroclas tic and equigranular lherzolites equilibrated at lower temperature.Keywords: Lithospheric mantle, lherzolites, harzburgites, websterites, olivine, deformation fabric.Resumen: Los xenolitos mantelitos en lavas alcalinas neógeno-cuaternarias de la Zona Volcánica de Cataluña indican que lherzolitas y harzburgitas ≪ anhidras≫  y con espinela son las rocas predominantes en el manto litosférico del NE de la Península Ibérica, con presencia también subordinada de websteritas olivínicas. Las orientaciones cristalográficas preferentes del olivino, determinadas por indexación de los espectros de difracción de electrones retrodispersados, muestran tres tipos de fábrica de deformación: una dominante, tipo axial [010], en peridotitas y websteritas equilibradas a alta temperatura, y otras subordinadas, de tipo ortorrómbico y axial [100], que aparecen en lherzolitas porfidoclásticas y equigranulares equilibradas a menor temperatura.Palabras clave: Manto litosférico, lherzolitas, harzburgitas, websterita, olivino, fábricas de deformación
Transformaciones morfosedimentarias de la bahía estuarina de Santander relacionadas con el desarrollo portuario y urbano (Cantabria, NO de España) Morphosedimentary transformations of the Santander estuarine bay related to port and urban development (Cantabria, NW Spain)
Authors: Flor G. , Flor-Blanco G.
Published: November 2018

Resumen: En el amplio complejo de la Bahía de Santander, coexisten dos subsistemas estuarinos muy contrastados. Numerosas transformaciones tuvieron lugar como consecuencia del desarrollo del gran puerto comercial y el crecimiento de la ciudad de Santander. Especialmente, las marismas fueron desnaturalizadas y se practicaron rellenos artificiales de forma mayoritaria en la margen occidental con la consiguiente reducción de espacios activos. Asimismo, se practicaron dragados intensos de manera particular en el canal principal que, a su vez, eliminaron el delta mareal de flujo, el paso y la barra de desembocadura. Estas prácticas, junto con los dragados de mantenimiento necesarios, han repercutido en fechas posteriores sobre la evolución de la espiga confinante de Somo-El Puntal, que experimenta un crecimiento longitudinal de varios cientos de metros hacia el O y un estrechamiento paulatino. Se cartografiaron las principales unidades morfosedimentarias desde la reconstrucción original previa de mediados de siglo xix en que se iniciaron las mayores transformaciones, considerando los hitos principales representativos desde 1956 hasta 2015. Se evidencian las ocupaciones paulatinas del margen occidental del subsistema de Santander por el puerto y la ciudad, el crecimiento de la espiga de Somo-El Puntal y la colonización vegetal del campo dunar culminante y los escasos rellenos del subsistema de Cubas, así como la fijación del canal de navegación en este último.Palabras clave: subsistemas estuarinos, unidades morfosedimentarias, cartografía, dragados, evolución histórica, Santander.Abstract: In the broad Bay of Santander, there are included two very contrasting estuarine subsystems. Many changes took place as a result of the development of large commercial port and urbanizing progressively of Santander city. Especially, marshes were reclaimed and have been covered by artificial fill in the western areas, and the consequent reduction in active spaces. Also the main navigation channel was intense dredged, and flood-tide delta, inlet and mouth bar were fully removed. These dredging activities subsequently had repercussions on the evolution of the Somo- El Puntal spit, which undergoes a longitudinal growth of several hundred meters to the W and a gradual narrowing. The main morpho-sedimentary units are mapped since the original distribution of mid-nineteenth century when major changes were initiated considering the major milestones representative from 1956 to 2015. Gradual occupation of the western marshes of the Santander subsystem, Somo-El Puntal spit migration and vegetal colonization of its dune field are evidenced as well as the scarce filling of the Cubas subsystem, where the navigation channel was fixed.Keywords: estuarine subsystems, morphosedimentary units, mapping, dredging, historical development, Santander.
La geología de Asturias a través de las Topografías Médicas The geology of Asturias through Medical Topographies
Authors: Gutiérrez Claverol M. , García-Ramos J. C.
Published: November 2018

Resumen: Se describe la aportación de médicos rurales a la divulgación de la geología asturiana. Evidentemente, aunque el grado de conocimiento geológico de sus autores no era el adecuado para hacer grandes aportaciones, colaboraron eficientemente, con la ayuda de la incipiente bibliografía disponible en aquella época, a popularizar esta rama científica. En este artículo se analizan brevemente los capítulos dedicados a la geología de las 19 Topografías Médicas escritas sobre concejos de Asturias que fueron galardonadas con el Premio García Roël. Quedan sin valorar 24 manuscritos no publicados, en su mayoría anónimos, que se conservan en las Reales Academias Nacionales de Medicina de Madrid y Barcelona.Palabras clave: Geología, Topografía Médica, siglos xix y xx, Asturias.Abstract: This article describes the contribution of rural doctors to the spread of knowledge on Asturian geology. Although the degree of geological competence of the authors was, obviously, not sufficiently developed to make major contributions, with the help of the available literatura they collaborated to popularizing this branch of science. This paper contains brief analyses of the chapters devoted to geology in 19 Medical Topographies on Asturian municipalities that were awarded the García Roël Prize. There are 24 other unpublished manuscripts, mostly anonymous, that remain for future address in the archives of the Royal National Academies for Medicine of Madrid and Barcelona.Keywords: Geology, Medical Topographies, xix and xx centuries, Asturias.
Control litológico y estructural de los deslizamientos en el monte Rodiles (Asturias, España) Lithological and structural control of landslides in the Rodiles Hill (Asturias, Spain)
Authors: Llana Fúnez S.
Published: November 2018

Resumen: El monte Rodiles, situado en el margen oriental de la ría de Villaviciosa, conserva evidencias de ocupación histórica desde sus orígenes como castro romanizado. El asentamiento está limitado en su vertiente sur por los restos de una muralla defensiva, mientras que en la ladera nororiental existen escarpes rocosos que debieron de actuar como defensa del enclave. Este trabajo realiza un análisis del relieve y revisa la estructura del sustrato geológico en el entorno próximo para determinar el origen de los escarpes en la ladera nordeste. Los datos de campo y el análisis de la topografía permiten identificar la existencia de varios deslizamientos que afectan a gran parte de la ladera nororiental del monte Rodiles. La masa deslizada aprovecha la inclinación de la sucesión litológica del Jurásico hacia el NE. La existencia de un nivel de arcillas, mecánicamente incompetentes, por debajo de los conglomerados de la Formación La Ñora, mecánicamente más competentes, permite el movimiento de la ladera hacia el mar. Estos escarpes están además alineados con la terminación lateral de una falla normal Mesozoica reactivada posteriormente como una falla inversa durante el levantamiento de la Cordillera Cantábrica. Las cicatrices de los deslizamientos, desarrolladas sobre niveles métricos de conglomerados fracturados, constituyeron por tanto una defensa natural del enclave histórico.Palabras clave: enclave histórico, deslizamientos, estabilidad de taludes, conglomerados jurásicos.Abstract: The Rodiles hill, on the eastern shores of the Villaviciosa estuary, preserves evidences of historic occupation since the romans. The settlement has a defensive wall in the south and is bounded to the north by a cragged slope to the sea. This work investigates the relief and the structure of the rocks in the area aiming at finding an origin for the crags in the northeastern slope of the hill. Field observations and the analysis of the topography reveal the presence of several landslides that affect most of the northeastern hillside. The dip of the Jurassic rock sequence to the NE and the presence of a two meter-thick layer of shales, mechanically very plastic, below the La Ñora conglomerates Formation, mechanically very competent, favours the slip of the hillside. The scarps are aligned with the lateral termination of a Mesozoic normal fault, reactivated as a reverse fault during the formation of the Cantabrian Mountains. The head scarps at the back of the landslides, developed on fractured conglomerates, constituted a natural defence during the historic settlement.Keywords: historic settlement, slides, slope stability, Jurassic conglomerates.
Espiriféridos (Brachiopoda) del Bashkiriense superior (Pensilvánico) de la formación Valdeteja, Asturias (N de España) Upper Bashkirian (Pennsylvanian) spiriferids (Brachiopoda) of the Valdeteja formation, Asturias (N of Spain)
Authors: Martínez Chacón M. Luisa , Sánchez de Posada Luis C.
Published: November 2018

Resumen: Se describen las características de la Formación Valdeteja y de las dos localidades estudiadas: Latores (SO Oviedo, Asturias) y Entrago (Teverga, Asturias), de edad Bashkiriense superior. Se analiza su historia, su importancia, las especies descritas y aquellas que tienen en Latores o Entrago su localidad tipo. Muchos de los órdenes de braquiópodos han sido estudiados en trabajos previos y en este se aborda el estudio de los espiriféridos, de los que se describen 16 especies, una de las cuales, Alphachoristites (Prochoristites) marcosi, es nueva. Algunos de los taxones descritos amplían sus rangos estratigráficos conocidos. Además, se analizan las características paleoecológicas y las relaciones paleobiogeográficas de estas asociaciones de braquiópodos.Palabras clave: Braquiópodos, espiriféridos, Formación Valdeteja, Bashkiriense superior, Zona Cantábrica, N España.Abstract: The characteristics of the Valdeteja Formation are described with special emphasis on the two fossiliferous localities of Latores (Oviedo, Asturias) and Entrago (Teverga, Asturias) dealt with in this paper. The history, significance and previously described species (several of them with its type locality either at Latores or Entrago) of these palaeontological sites are analyzed. In fact, most of brachiopod orders of these localities have been previously studied, but this is not the case of the Spiriferida studied here. Sixteen species are described, one of them –Alphachoristites (Prochoristites) marcosi– is new. The stratigraphical ranges of some described taxa are extended. Finally, the palaeoecology and palaeobiogeographical affinities of these brachiopod assemblages are analyzed.Keywords: Brachiopods, spiriferids, Valdeteja Formation, upper Bashkirian, Cantabrian Zone, N Spain.
Deformación asociada a la falla de Valdoviño (Noroeste del Macizo Ibérico) Deformation related to the Valdoviño fault (Northwest Iberian Massif)
Authors: Fernández F. J. , Llana-Fúnez S.
Published: November 2018

Resumen: La sección costera de la falla de Valdoviño expone rocas de falla deformadas en las proximidades de la base de la zona sismogénica de la corteza Ibérica Varisca, en la que estructuras frágiles discretas afectan una zona de deformación predominantemente dúctil. El núcleo de la falla contiene rocas ultramáficas, rocas máficas con granate, anfibolitas, neises cuarzo-feldespáticos y metavulcanitas básicas entre las facies deformadas del granitoide Varisco de A Espenuca. Este artículo describe la deformación y microestructuras relacionadas con la falla desarrolladas en el granitoides. La composición y características tectonometamórficas del resto de rocas presentes en el núcleo de la falla sugieren que las estructuras asociadas a la falla se superpusieron a fábricas tectónicas previas, similares a las que presentan las rocas de los complejos alóctonos del NO del Macizo Ibérico.Palabras clave: microestructura, rocas de falla, corteza continental, EBSD, Orógeno Varisco.Abstract: The coastal section across the Valdoviño fault exposes fault-related rocks deformed at the base of the seismogenic zone of the Iberian Variscan crust. Discrete brittle structures are superimposed over previous predominant ductile deformation fabrics in most rocks. The core of the fault contains ultramafic rocks, garnet-bearing mafic rocks, amphibolites, quartzo-feldspathic gneisses and basic metavulcanites, in between the deformed facies of the A Espenuca Variscan granitoid. We show the deformation and microstructures related to the fault developed in the Variscan granitoid. The composition and tectonometamorphic features of the rest of the related rocks at the core of the fault suggest that deformation structures are superposed onto earlier tectonic fabrics, similar to those present in the rocks of the allochthonous complexes of the NW Iberian Massif.Keywords: microstructure, fault-related rocks, continental crust, SEM-EBSD, Variscan Orogeny.
The Undisclosed Chapter of the Textbook on Electrical Engineering
Authors: Andreevich Parfentiev Nikolay
Published: November 2018

A special point was found in the frequency characteristics of the oscillatory circuit, which was not mentioned earlier in textbooks on electrical engineering and radio engineering. The module of complex resistance of the circuit does not depend on the value of the active resistance at a frequency less than  times that of the resonance. The material is of interest to all engineers and scientists specializing in electrical engineering. On its basis, new methods for measuring the parameters of electrical circuits can be developed. Physical interpretation of the phenomenon doesn't exist at the moment.
Reform and Practice of Electrical and Electronic Experiment Teach-ing
Authors: Bauer Yedda , Wheeler Dorothy
Published: November 2018

Electrical and electronic experiment teaching plays an important role in cultivating students in electrical majors. To this end, we must reform the traditional experimental teaching methods. Electric and electronic experiment teaching body Some measures to reform the teaching mode of soft experiment . real Practice results verify its effectiveness .
A survey availability of kerosene is the leading cause of suicidal burns-death of females in Salem district, Tamil Nadu, India
Authors: Rajendran M. K.
Published: November 2018

Background: Kerosene is the main culprit for the Burns, occupy 90% remaining 10% burns from other cause that to availability of kerosene at home /working place is the leading provocating cause for suicidal burns, For the past 7 years, we have followed 2645 burns admission (total) that too female burns, almost 98% of them are due to kerosene. In most of the case, suicide is due to some family problem. The remaining 10% burns are accidental burns to assess the burns due to kerosene usage and to analysis the mortality and morbidity among patients.Methods: This survey was conducted from 2010 to 2017. The number of burns patient admitted at our hospital is 2645/ female burns. cause of suicide attempting by self-immolation during 7 years 2010-2017 analyzed. A record sheet designed to extract data such as age, education, occupation, gender, residence, marital status, drug abuse, and extent of the burn injuries as a percent of burned total body surface area (TBSA).Results: A detailed survey conducted for the past 7 years female Burns are almost 90%. Due to suicide remaining 10% accidental. Accidental burns are minor/ moderate. We are able to save the life and reduce the mortality. But suicidal burns almost extensive/ major burns. We are not able to save the life with modern availability of treatment.Conclusions: Finding of the current study manifested a high rate of suicide by self-immolation among young, married, and low educated women in south India. It implies a social problem, and need to an arrangement of a cultural program aimed at improving health, psychological habits, and educational level.
Dermatome mapping: easy to do with formidable results: our experience
Authors: Kirtania Dona , Kirtania Dona
Published: November 2018

Background: Although the recurrence rates after Hernia Surgeries have declined, a new complication, the chronic post-operative pain has crept up. The existing methods of assessment of post-operative disability and surgical limitations are non-consistent and unreliable. Álvarez et al suggested a novel way of mapping the affected dermatomes after hernia surgery and incorporating factors like side, source, type, distribution and intensity of pain into a classification system called Dermatome mapping classification (DMC). The DMC is an easy to do office based evaluation that uses just the surgeon’s ballpoint pen, and a photograph for further reference.Methods: We observed 100 patients’ after Open Hernioplasty, conducted a Dermatome mapping and summarized our result. Results: Most of our patients had some pain and discomfort within the first week of the surgery that gradually declined. The DMC successfully predicted an iatrogenic denervation and also provided on the incidence of post-operative pain ~ 8% in the 100 patients whom we evaluated. The Ilio-inguinal nerve was the most commonly affected nerve.Conclusions: The DMC is an objective record of the subjective assessment of the post-operative patient and it provides the surgeon with an insight on the result and efficacy of the surgery being performed. The technique is equally productive for evaluating Open and Laparoscopic Hernia repairs or planning and evaluating Neurectomies for chronic pain.
Observational study of appropriateness of colonoscopy using appropriateness criteria designed by EPAGE
Authors: Kale Bhushan R. , Iyer Sandhya , Subramanian Prabhakar
Published: November 2018

Background: To evaluate the appropriateness of colonoscopy for various common indications observed in day to day outpatient and inpatient general surgical practice as per criteria devised by expert panel of EPAGE 2.Methods: Appropriateness score for indication of colonoscopy was calculated from EPAGE official website and the colonoscopy findings were verified against appropriateness score. The effect of various parameters like age, sex, duration of symptoms and referring doctor individually on both EPAGE score as well as colonoscopy results was verified.Results: In our study, we found that only age of patient statistically affects EPAGE score. We also found that there is correlation between EPAGE score and colonoscopy results.Conclusions: As age of patient increases likelihood of getting a significant EPAGE score increases while other parameters like sex, duration of symptoms, referring physicians did not affect EPAGE score in our study. The probability of getting positive findings on colonoscopy increases if the indication of colonoscopy is proved appropriate by EPAGE. All other parameters did not affect the colonoscopy findings in our study.
Impact of different meshes on patient reported outcomes and complications following TEP repair: a comparative approach
Authors: Jindal Sanam , Kakkar Arun , Jhamb Yogesh , Lamba Jasdeep Singh
Published: November 2018

Background: Minimally invasive inguinal hernia surgery originated in the early 1990s and is gaining popularity in the field of general surgery. A mesh provides a tension-free repair with strengthening of the abdominal wall. This study was undertaken to compare traditional polypropylene and lightweight meshes in TEP inguinal hernioplasty in terms of post-operative patient reported outcomes.Methods: A total of 65 patients were enrolled in the study. Patients were divided into 3 groups i.e. Polypropylene (21), TiMesh-16 (24) and Ultrapro (20) based on mesh used. Assessment of pain was done using visual analogue scale (VAS). Patient reported outcomes were observed on 1st post-operative day (POD), 7th day, 1 month, 6 months and 1 year. Data was analysed using SPSS software ver.22.Results: A total of 94 hernias were operated in 65 patients. Mean operative time in both unilateral and bilateral cases was not significant and showed no correlation with type of mesh used. Mean VAS score of prolene group was significantly more than Ultrapro and TiMesh groups on POD1, POD7, 1 month and 6 months, showing p=0.027 (POD1), p=0.002 (POD7), p=0.017 (1 month) and p=0.00 (6 months) respectively. Patients in LWM groups showed earlier return to activities than Prolene group. No recurrence was observed in either group on 1 year follow-up. Among the study patients, complications of TEP observed were accidental rupture of peritoneum, scrotal swelling, seroma, sub-cutaneous emphysema and conversion to lichtenstein mesh hernioplasty.Conclusions: As per the observations, Light weight mesh placement in TEP Hernioplasty results in better patient reported outcomes.
Innovation capability assessment on business incubators performance using resources, leadership and capability: An investigation in business incubators from Chile, Italy and Israel
Authors: Martins Oliveira Selma Regina , Trento Sandro
Published: November 2018

This study aims to assess the innovation capabilities on the business incubators performance using resources, leadership and capability in three countries: Chile, Israel and Italy. This research was elaborated in light of theoretical excerpts, with foundation in the model, which considers the following metrics: resources, enablement and leadership. Furthermore, in order to demonstrate the feasibility and plausibility of the model, a multiple case study was conducted in business incubators. The research had specialistsâ€™ intervention, with knowledge and experience in the innovation management field, selected by the technical and scientific criteria. The data were extracted by a judging matrix with a scale type, in which the specialists gave their opinions, establishing priorities to the variables, by level of importance. In order to reduce the subjectivity in the results reached, it was used statistical techniques of multivariate analysis and multi-criteria analysis, with the support of the Electre III, Compromise Programming e Promethee II methods. The results were satisfactory, validating the modelling approach.Keywords: Innovation capabilities, innovation performance, assessment, business incubators.
Determinants of venture capital performance in Indonesia
Authors: Prasetyo Ahmad Danu , Imran Muhammad Febrizal , Rizka Fania Anindita , Fachira Ira
Published: November 2018

The growth of venture capital in Indonesia from year to year is smaller compared to other industries, both financial institutions and non-bank financial industry. Due to these weak performances, there is an urgency for venture capitals in Indonesia to improve their performances. For this purpose, we need to identify factors influencing venture capital performance in Indonesia as well as to determine their weighting scheme. The research was conducted to fill the gap. In this research, we combined qualitative and quantitative method through an in-depth interview and analytical hierarchy process method. We found that reputation was considered as the most important factor that contributes 37.4% to the overall score. Network broadness ranked second with weigh 13.7%, followed by syndication, macroeconomic condition, exit plan strategy, staging strategy, diversification strategy and funding scheme, respectively.Keywords: Venture Capital, determinants, in-depth interview, analytical hierarchy process, Indonesia.
Identification of modern amenities in accommodation servicesâ€”Analysis for Polish business tourism
Authors: Zontek Ewa Lipianin , Zontek Zbigniew , Szewczyk Irena
Published: November 2018

This paper presents an overview of the issues related to the readiness of Polish hotel establishments to develop business tourism services. Hotels that support business tourism need to constantly evaluate the potential competitiveness of tourism offers, to enable them to improve their product development. Modern trends in these services are forcing the industry into continuous improvement and innovation. The aim of this paper is to identify new innovative amenities for business tourism around the world and, consequently, to diagnose the competitiveness of facilities in Polish hotels. Statistical data shows that business tourism in Poland has many development opportunities. However, for their effective utilisation, hotel establishments should develop their resources in terms of both quantity and quality.

Keywords: Business tourism, accommodation services, amenities.
Exploring the relationship between adjustment cost and stickiness cost
Authors: Eltivia Nurafni , Ekasari Kurnia , Wahyuni Hesti
Published: November 2018

The purpose of this study was to analyse the stickiness cost, and how adjustment cost gave impact on stickiness cost. Asset intensity was proxy of adjustment cost in this research. The population of this research is manufacturing companies listed in Indonesia Stock Exchange in 2016. There are 124 companies obtained by using purposive sampling method. The analysis tool used is multiple linear regression. The results showed that stickiness cost occurred on manufacturing companies listed in Indonesia Stock Exchange. Furthermore, the results indicate the level of asset intensity in accordance with the level of stickiness cost changes. So it can be concluded that adjustment cost affects stickiness cost.Keywords: Adjustment cost, stickiness cost, asset intensity.
The travel consumer
Authors: Mimoso Maria Joao , Anjos Maria Rosario , Almeida Andre , Castro Patricia Daniela
Published: November 2018

Given the increase in intra-Community travel, in particular â€˜package travelâ€™, the European Union legislature felt it necessary to define a set of rules common to all States Members. In the attempt to combat the inequalities between those who hire this type of services and the companies that organise the trips. We propose to critically analyse this new legal instrument and discuss its scope of consumer protection. The European legislature intends by Directive 2015/2302 harmonise the rights and obligations arising from contracts for package travel and related travel services. It aims to create a true internal market for consumers, establishing a good balance between a high level of consumer protection and the competitiveness of enterprises. The rights of travellers will be better protected, in matters such as compensation, cancellation, assistance, among others. On the other hand, we see the standardisation of the concept of organised trips ending differences in doctrine and jurisprudence.Keywords: Consumer, traveller, directive, protection, organised trip.
Adjustment for elderly and disabled tourists in polish hotels-strength or weakness
Authors: Szewczyka Irena , Zontek Ewa Lipianin
Published: November 2018

Purpose: The environment may create or maintain internal and external barriers to the participation of elderly people and people with disabilities in life. The purpose of this paper is to evaluate accessibility of hotels for the segment of elderly people and people with disabilities in Poland.Design: The study established a research hypothesis: The hotels are not prepared for the segment elderly people and people with disabilities. The paper analyses the market hotels in Poland.Findings: Results of the research conducted show that hotel must be adapted to the needs of the segment of elderly people and people with disabilities.Originality: Not a lot of research has been done on accessible hotel tourism for elderly and disabled guests. The paper presents suggestions on what the disabled guests await from the polish hotels.Keywords: disabled tourist, elderly, seniors, disability, accessible object
Multiple linear regression-based physical fitness prediction models for Turkish secondary school students
Authors: Akay Mehmet Fatih , Bozkurt Ozge , Cetin Ebru , Yarim Imdat
Published: November 2018

Physical fitness is a necessary component for daily activities. Measurement of physical activity is essential for determining physical fitness rate. This study aims to develop new prediction models for predicting the physical fitness of Turkish secondary school students by using multiple linear regression (MLR). The datasets comprise data of various number of subjects according to the target variables including the test scores of the 30m speed, 20m stage run, balance and hand-grip (right/left). The predictor variables used to develop the prediction models are gender, age, body mass index (BMI), body fat, number of curl-up and push-ups in 30 seconds. Eight physical fitness prediction models for each target have been created with the predictor variables listed above. The performance of the prediction models has been calculated by using standard error of estimate (SEE). The results show that MLR-based prediction models can be safely used to predict the physical fitness of Turkish secondary school students.Keywords: Physical fitness, multiple linear regression, machine learning, validation.
Identification of studentsâ€™ learning motivation
Authors: Saygili Gizem
Published: November 2018

The purpose of this study is to identify the overall learning motivation of primary and middle school students. In this research study, the effect of such variables as gender, parentsâ€™ educational status, academic achievement and grade level on primary and middle school studentsâ€™ intrinsic and extrinsic motivation levels were investigated. This study has a descriptive model as it aims to reveal and explain the current situation in detail. The participants of this study were primary and middle school students from different schools in Isparta. The motivation level detection scale was administered to determine the overall learning motivation of the participants. Mannâ€“Whitney U and Kruskalâ€“Wallis T tests were used to compare the mean scores with respect to variables. The results imply that the intrinsic and extrinsic motivation levels of the primary school students who participated in this study did not differ in their gender, academic achievement and their parentsâ€™ educational status.Keywords: Primary school education, learning, learning motivation.
How the attitude towards the learning process is influenced at Romanian teeenager â€˜pupils by their well-being status?
Authors: Urea Ionela Roxana
Published: November 2018

Learning process, depending on the personâ€™s age, requires the personâ€™s resources in relation to their form (formal or informal), their purpose and their content. In schools, the learning process takes place in a specific environment that should be secure and involves two major players: teacher(s) and pupil(s). Each party comes with a specific â€˜luggageâ€™ (health level, family background, economical background, personal well-being status, etc.) that supports the acquisition of skills, abilities and knowledge, and also favour the developing of learning styles, communication styles, specific attitudes, personality traits and so on. Each party has their own learning process agenda; pupils will acquire specific and transversal competencies, and teachers will be more efficient in using educational strategies, methods, techniques and procedures. The conclusions that came after administration of specific psychological instruments reveal an interesting influence of the well-being level upon the attitude towards learning activities.Keywords: Well-being, attitude towards learning process, teenagers, educational training process.