bluuebunny/crossref_metadata_2025 huggingface dataset:
Historical droughts recorded in extended Juniperus procera ring-width chronologies from the Ethiopian Highlands
Authors: Gebregeorgis E. Gebrehiwot , Robertson I. , Koprowski M. , Zhou L. P. , Gao P. , Williams A. P. , Eshetu Z. , Wils T. H. G.
Published: February 2020

In the Horn of Africa, little is known about temporal changes in hydroclimate owing to the influence of multiple weather systems, the complex terrain, and the sparse instrumental records. Absolutely dated tree-ring records offer the potential to extend our understanding of climate into the pre-instrumental era, but tree-ring studies in this region, and indeed all of tropical Africa, have been rare largely due to lack of an annual climate cycle that reliably produces annual tree-rings. In this study, 40 cores were obtained from 31 Juniperus procera trees growing in the grounds of Ethiopian Orthodox Tewahedo churches in the Gonder region of Ethiopia. The samples were cross-dated using a re-iterative process involving identifying anatomical features from high-resolution images. The tentative ring-width chronologies were revised after the determination of bomb-peak accelerator mass spectrometry radiocarbon dates. Individual series were significantly correlated to the respective master chronologies (r > 0.55; P < 0.05), and expressed population signal values ranged from 0.55 to 0.92. Historical drought years were successfully traced in the chronologies by pointer year analysis. This study confirms that Juniperus procera growing in areas of unimodal precipitation exhibits annual tree-rings and offers the potential as an indirect measure of past climate.
Parametric study of 3D printed microneedle (MN) holders for interstitial fluid (ISF) extraction
Authors: Taylor Robert M. , Maharjan Dilendra , Moreu Fernando , Baca Justin T.
Published: February 2020

The need for novel, minimally invasive diagnostic, prognostic, and therapeutic biomedical devices has garnered increased interest in recent years. Microneedle (MN) technology has stood out as a promising new method for drug delivery, as well as extraction of interstitial fluid (ISF). ISF comprises a large portion of the extracellular fluid in living organisms yet remains inadequately characterized for clinical applications. Current MN research has focused on the fabrication of needles with different materials like silicone, carbon, and metals. However, little effort has been put forth into improving MN holders and patches that can be used with low cost MNs, which could effectively change how MNs are attached to the human body. Here, we describe different 3D-printed MN holders, printed using an MJP Pro 2500 3D printer, and compare the ISF extraction efficiencies in CD Hairless rats. We varied design parameters that may affect the skin-holder interface, such as throat thickness, tip curvature, and throat diameter. MN arrays, with insertion depths of 1500 μm, had extraction efficiencies of 0.44 ± 0.35, 0.85 ± 0.64, 0.32 ± 0.21, or 0.44 ± 0.46 µl/min when designed with flat, concave, convex, or bevel profile geometries, respectively. Our results suggest ISF extraction is influenced by MN holder design parameters and that a concave tip design is optimal for extracting ISF from animals. The future direction of this research aims to enable a paradigm in MN design that maximizes its efficiency and engineering performance in terms of volume, pressure, and wearability, thereby automatizing usage and reducing patient intervention to ultimately benefit remote telemedicine.
A potent risk model for predicting new-onset acute coronary syndrome in patients with type 2 diabetes mellitus in Northwest China
Authors: Lyu Jun , Li Zhiying , Wei Huiyi , Liu Dandan , Chi Xiaoxian , Gong Da-Wei , Zhao Qingbin
Published: February 2020

Aims

Type 2 diabetes mellitus (T2DM) is now very prevalent in China. Due to the lower rate of controlled diabetes in China compared to that in developed countries, there is a higher incidence of serious cardiovascular complications, especially acute coronary syndrome (ACS). The aim of this study was to establish a potent risk predictive model in the economically disadvantaged northwest region of China, which could predict the probability of new-onset ACS in patients with T2DM.

Methods

Of 456 patients with T2DM admitted to the First Affiliated Hospital of Xi’an Jiaotong University from January 2018 to January 2019 and included in this study, 270 had no ACS, while 186 had newly diagnosed ACS. Overall, 32 demographic characteristics and serum biomarkers of the study patients were analysed. The least absolute shrinkage and selection operator regression was used to select variables, while the multivariate logistic regression was used to establish the predictive model that was presented using a nomogram. The area under the receiver operating characteristics curve (AUC) was used to evaluate the discriminatory capacity of the model. A calibration plot and Hosmer–Lemeshow test were used for the calibration of the predictive model, while the decision curve analysis (DCA) was used to evaluate its clinical validity.

Results

After random sampling, 319 and 137 T2DM patients were included in the training and validation sets, respectively. The predictive model included age, body mass index, diabetes duration, systolic blood pressure (SBP), diastolic blood pressure (DBP), low-density lipoprotein cholesterol, serum uric acid, lipoprotein(a), hypertension history and alcohol drinking status as predictors. The AUC of the predictive model and that of the internal validation set was 0.830 [95% confidence interval (CI) 0.786–0.874] and 0.827 (95% CI 0.756–0.899), respectively. The predictive model showed very good fitting degree, and DCA demonstrated a clinically effective predictive model.

Conclusions

A potent risk predictive model was established, which is of great value for the secondary prevention of diabetes. Weight loss, lowering of SBP and blood uric acid levels and appropriate control for DBP may significantly reduce the risk of new-onset ACS in T2DM patients in Northwest China.
Phylogenetic placement of Ivodea and biogeographic affinities of Malagasy Rutaceae
Authors: Appelhans Marc S. , Wen Jun
Published: February 2020

The genusIvodeais endemic to Madagascar and the Comoros and consists of 30 species. This study is the first to include the genus in a molecular phylogenetic analysis. We sequenced the plastidtrnL–trnF and the nuclear ITS regions for threeIvodeaspecies and revealed that the genus is monophyletic and most closely related to the African and MalagasyVepris, refuting earlier suggestions of a close relationship betweenIvodeaand the Asian, Malesian, Australasian and Pacific generaEuodiaandMelicope.IvodeaandVeprisprovide another example of closely related pairs of Rutaceous groups that have drupaceous and capsular/follicular fruits, respectively, thus further confirming that fruit types are not suited to delimit subfamilies in Rutaceae, as has often been done in the past.Ivodeawas the last of the seven Malagasy genera to be included in the Rutaceae phylogeny, making it possible to conduct an assessment of biogeographic affinities of the genera that occur on the island. Our assessments based on sister-group relationships suggest that the eight lineages (representing seven genera) of Malagasy Rutaceae either have African or have Asian affinities. Two lineages have an African origin, and one lineage has an Asian origin. Taxon sampling is insufficient to interpret the directionality of dispersal events in the remaining lineages.
Model-based reconstruction and projections of soil moisture anomalies and crop losses in Poland
Authors: Piniewski Mikołaj , Marcinkowski Paweł , O’Keeffe Joanna , Szcześniak Mateusz , Nieróbca Anna , Kozyra Jerzy , Kundzewicz Zbigniew W. , Okruszko Tomasz
Published: February 2020

Evidence shows that soil moisture (SM) anomalies (deficits or excesses) are the key factor affecting crop yield in rain-fed agriculture. Over last decades, Poland has faced several major droughts and at least one major soil moisture excess event leading to severe crop losses. This study aims to simulate the multi-annual variability of SM anomalies in Poland, using a process-based SWAT model and to assess the effect of climate change on future extreme SM conditions, potentially affecting crop yields in Poland. A crop-specific indicator based on simulated daily soil moisture content for the critical development stages of investigated crops (winter cereals, spring cereals, potato and maize) was designed, evaluated for past conditions against empirical crop-weather indices (CWIs), and applied for studying future climate conditions. The study used an ensemble of nine bias-corrected EURO-CORDEX projections for two future horizons: 2021–2050 and 2071–2100 under two Representative Concentration Pathways: RCP4.5 and 8.5. Historical simulation results showed that SWAT was capable of capturing major SM deficit and excess episodes for different crops in Poland. For spring cereals, potato and maize, despite a large model spread, projections generally showed increase of severity of soil moisture deficits, as well as of total area affected by them. Ensemble median fraction of land with extreme soil moisture deficits, occupied by each of these crops, is projected to at least double in size. The signals of change in soil moisture excesses for potato and maize were more dependent on selection of RCP and future horizon.
Inhibition of antigen-specific immune responses by co-application of an indoleamine 2,3-dioxygenase (IDO)-encoding vector requires antigen transgene expression focused on dendritic cells
Authors: Sudowe Stephan , Höhn Yvonne , Renzing Andrea , Maxeiner Joachim , Montermann Evelyn , Habermeier Alice , Closs Ellen , Bros Matthias , Reske-Kunz Angelika B.
Published: February 2020

We have previously shown that particle-mediated epidermal delivery (PMED) of plasmids encoding β-galactosidase (βGal) under control of the fascin-1 promoter (pFascin-βGal) yielded selective production of the protein in skin dendritic cells (DCs), and suppressed Th2 responses in a mouse model of type I allergy by inducing Th1/Tc1 cells. However, intranasal challenge of mice immunized with pFascin-βGal induced airway hyperreactivity (AHR) and neutrophilic inflammation in the lung. The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in immune suppression and tolerance induction. Here we investigated the consequences of co-application of an IDO-encoding vector on the modulatory effect of DNA vaccination by PMED using pFascin-βGal in models of eosinophilic allergic and non-eosinophilic intrinsic airway inflammation. IDO-encoding plasmids and pFascin-βGal or pCMV-βGal were co-applied to abdominal skin of BALB/c mice without, before or after sensitization with βGal protein. Immune responses in the lung were analysed after intranasal provocation and airway reactivity was determined by whole body plethysmography. Co-application of pCMV-IDO with pFascin-βGal, but not pCMV-βGal inhibited the Th1/Tc1 immune response after PMED. Moreover, AHR in those mice was attenuated following intranasal challenge. Therapeutic vaccination of βGal-sensitized mice with pFascin-βGal plus pCMV-IDO slightly suppressed airway inflammation and AHR after provocation with βGal protein, while prophylactic vaccination was not effective. Altogether, our data suggest that only the combination of DC-restricted antigen and ubiquitous IDO expression attenuated asthma responses in mice, most probably by forming a tryptophan-depleted and kynurenine-enriched micromilieu known to affect neutrophils and T cells.
Clinical performance of non-precious metal double crowns with friction pins in severely reduced dentitions
Authors: Hinz Sebastian , Schweyen Ramona , Hey Jeremias , Setz Juergen , Arnold Christin
Published: February 2020

Objectives

Several in vitro studies have investigated the retention of double crowns with friction pins (DCP); however, clinical data on their long-term success have not been reported. We sought to evaluate the 5-year survival rate of DCPs in patients with severely reduced dentition (SRD) and not severely reduced dentition (NSRD).

Materials and methods

A total of 158 patients were treated with 182 dentures on 520 abutment teeth between 2006 and 2016. The SRD group included 144 dentures that had been inserted on 314 abutment teeth. We evaluated the influence of age, sex, jaw, number, tooth vitality, and abutment teeth localization (according to Steffel’s classification) on the 60-month survival rates of dentures and abutment teeth using the Kaplan-Meier estimator, logrank test, and Cox regression.

Results

The cumulative 60-month survival rate was 84.3% (CI 77.1–91.5%) for all dentures; however, the survival rate in the SRD group (80.3%; CI 71.5–89.1%) was significantly lower than in the NSRD group (100%; p = 0.04). Dentures classified in Steffel’s class A had the lowest survival rate (51.5%; CI 30.9–72.1%). Number, location, and vitality of the abutment teeth had a significant impact on survival rate.

Conclusions

DCP dentures showed comparable clinical long-term success to double crown systems that have been previously reported in the literature. The number, localization, and vitality of abutment teeth had the greatest influence on the survival rates of denture and abutment teeth.

Clinical relevance

DCP dentures have an acceptable 5-year survival rate. Clinical treatment planning must take into account key factors associated with the prognosis of the abutment teeth.
Co-occurring obsessive–compulsive disorder and autism spectrum disorder in young people: prevalence, clinical characteristics and outcomes
Authors: Martin Alex F. , Jassi Amita , Cullen Alexis E. , Broadbent Matthew , Downs Johnny , Krebs Georgina
Published: February 2020

Obsessive–compulsive disorder (OCD) and autism spectrum disorders (ASD) commonly co-occur and are considered challenging to manage when they co-occur in youth. However, clinical characteristics and prognosis of this group remain poorly understood. This study examined the prevalence, clinical correlates and outcomes of paediatric OCD co-occurring with ASD (OCD + ASD) in a large clinical cohort. Data were extracted from electronic clinical records of young people aged 4–17 years who had attended a mental health trust in South London, United Kingdom. We identified young people with diagnoses of OCD + ASD (n = 335), OCD without ASD (n = 1010), and ASD without OCD (n = 6577). 25% of youth with OCD had a diagnosis of ASD, while 5% of those with ASD had a diagnosis of OCD. At diagnosis, youth with OCD + ASD had lower psychosocial functioning scores on the clinician-rated Child Global Assessment Scale (CGAS) compared to those with either OCD or ASD. Youth with OCD + ASD were equally likely to receive CBT compared to those with OCD but were more likely to be prescribed medication and use services for longer than either comparison group. Youth with OCD + ASD showed significant improvements in functioning (CGAS scores) after service utilisation but their gains were smaller than those with OCD. OCD + ASD commonly co-occur, conferring substantial impairment, although OCD may be underdiagnosed in youth with ASD. Young people with co-occurring OCD + ASD can make significant improvements in functioning with routine clinical care but are likely to remain more impaired than typically developing youth with OCD, indicating a need for longer-term support for these young people.
Patients with coronary artery disease after acute myocardial infarction: effects of continuous enrollment in a structured Disease Management Program on adherence to guideline-recommended medication, health care expenditures, and survival
Authors: Kirsch Florian , Becker Christian , Schramm Anja , Maier Werner , Leidl Reiner
Published: February 2020

Objective

Acute myocardial infarction (AMI) carries increased risk of mortality and excess costs. Disease Management Programs (DMPs) providing guideline-recommended care for chronic diseases seem an intuitively appealing way to enhance health outcomes for patients with chronic conditions such as AMI. The aim of the study is to compare adherence to guideline-recommended medication, health care expenditures and survival of patients enrolled and not enrolled in the German DMP for coronary artery disease (CAD) after an AMI from the perspective of a third-party payer over a follow-up period of 3 years.

Methods

The study is based on routinely collected data from a regional statutory health insurance fund (n = 15,360). A propensity score matching with caliper method was conducted. Afterwards guideline-recommended medication, health care expenditures, and survival between patients enrolled and not enrolled in the DMP were compared with generalized linear and Cox proportional hazard models.

Results

The propensity score matching resulted in 3870 pairs of AMI patients previously and continuously enrolled and not enrolled in the DMP. In the 3-year follow-up period the proportion of days covered rates for ACE-inhibitors (60.95% vs. 58.92%), anti-platelet agents (74.20% vs. 70.66%), statins (54.18% vs. 52.13%), and β-blockers (61.95% vs. 52.64%) were higher in the DMP group. Besides that, DMP participants induced lower health care expenditures per day (€58.24 vs. €72.72) and had a significantly lower risk of death (HR: 0.757).

Conclusion

Previous and continuous enrollment in the DMP CAD for patients after AMI is a promising strategy as it enhances guideline-recommended medication, reduces health care expenditures and the risk of death.
The impact of a road safety policy implementation within an international organization
Authors: Dandebo Lovisa , Dimberg Lennart M. , Goldoni Laestadius Jasminka
Published: February 2020

Aim

This study was performed within an international organization (IO), headquartered in Washington, D.C. The employees are facing great risks during their missions abroad, where developing countries are the most common travel destination. The IO conducted a staff road safety survey in 2008 and based a road safety policy on the results of this survey. In 2017, a follow-up survey investigated the impact of the policy implementation. The aim of this study was to investigate the effect of that policy.

Subjects and methods

This study is based on two cross-sectional road safety surveys conducted by the IO’s Staff Road Safety Task Force. The study population consisted of both regular employees and consultants based at country offices (CO) worldwide. The number of reported road traffic crashes and near-crashes (nearly had a crash), as well as road safety behavior, was compared between these two surveys. The analysis was performed from a gender perspective. High-risk countries were identified based on the number of reported road traffic crashes and near-crashes.

Results

Over a period of nine years, the incidence rates had dropped from 1.6 to 0.7 road traffic crashes per 1000 travel days and from 14 to 8.9 near-crashes per 1000 travel days. Seat belt usage had increased from 70% to 80%. There were no major differences between male and female respondents. Developing countries had the highest travel adjusted event rates.

Conclusion

The findings of this study suggest that the policy had a positive impact on road safety among CO staff within the IO.
Modeling law search as prediction
Authors: Dadgostari Faraz , Guim Mauricio , Beling Peter A. , Livermore Michael A. , Rockmore Daniel N.
Published: February 2020

Law search is fundamental to legal reasoning and its articulation is an important challenge and open problem in the ongoing efforts to investigate legal reasoning as a formal process. This Article formulates a mathematical model that frames the behavioral and cognitive framework of law search as a sequential decision process. The model has two components: first, a model of the legal corpus as asearch spaceand second, a model of the search process (orsearch strategy) that is compatible with that environment. The search space has the structure of a “multi-network”—an interleaved structure of distinct networks—developed in earlier work. In this Article, we develop and formally describe three related models of the search process. We then implement these models on a subset of the corpus of U.S. Supreme Court opinions and assess their performance against two benchmark prediction tasks. The first is to predict the citations in a document from its semantic content. The second is to predict the search results generated by human users. For both benchmarks, all search models outperform a null model with the learning-based model outperforming the other approaches. Our results indicate that through additional work and refinement, there may be the potential for machine law search to achieve human or near-human levels of performance.
Spectral decomposition of the Engineering Strong Motion (ESM) flat file: regional attenuation, source scaling and Arias stress drop
Authors: Bindi D. , Kotha S. R.
Published: February 2020

We perform a spectral decomposition of the Fourier amplitude spectra disseminated along with the Engineering Strong Motion (ESM) flat file for Europe and Middle East. We apply a non-parametric inversion schema to isolate source, propagation and site effects, introducing a regionalization for the attenuation model into three domains. The obtained propagation and source components of the model are parametrized in terms of geometrical spreading, quality factor, seismic moment, and corner frequency assuming a ω2source model. The non-parametric spectral attenuation values show a faster decay for earthquakes in Italy than in the other regions. Once described in terms of geometrical spreading and frequency-dependent quality factor, slopes and breakpoint locations of the piece-wise linear model for the geometrical spreading show regional variations, confirming that the non-parametric models capture the effects of crustal heterogeneities and differences in the anelastic attenuation. Since they are derived in the framework of a single inversion, the source spectra of the largest events which have occurred in Europe in the last decades can be directly compared and the scaling of the extracted source parameters evaluated. The Brune stress drop varies over about 2 orders of magnitude (the 5th, 50th and 95th percentiles of the ∆σ distribution are 0.76, 2.94, and 13.07 MPa, respectively), with large events having larger stress drops. In particular, the 5th, 50th and 95th percentiles forM > 5.5 are 2.87, 6.02, and 23.5 MPa, respectively whereas, forM < 5.5, the same percentiles are 0.73, 2.84, and 12.43 MPa. If compared to the residual distributions associated to a ground motion prediction equation previously derived using the same Fourier amplitude spectra, the source parameter and the empirical site amplification effects correlate well with the inter-event and inter-station residuals, respectively. Finally, we calibrated both non-parametric and parametric attenuation models for estimating the stress drop from the ratio between Arias intensity and significant duration. The results confirm that computing the Arias stress drop is a suitable approach for complementing the seismic moment with information controlling the source radiation at high frequencies for rapid response applications.
Monitoring and assessment of cadmium, lead, zinc and copper concentrations in arable roadside soils in terms of different traffic conditions
Authors: Szwalec Artur , Mundała Paweł , Kędzior Renata , Pawlik Justyna
Published: February 2020

Quantification of the contributions from traffic source to arable roadside soil heavy metal loadings is a challenge. The contribution depends on: traffic intensity, road type and distance from the road. At a field scale (3.9 ha), 720 topsoil samples were taken. The aim of the study was to monitor and assess the impact of regional/local roads with various conditions of traffic and period of use on the distribution of Cd, Zn, Pb and Cu in the arable roadside topsoil in their vicinity. PCA indicated the occurrence of two main gradients of 11 environmental elements influencing the distribution of heavy metals in the soils of the neighbouring land. The first gradient was associated mainly with the distance from the edge of the road. The second gradient was associated with the degree of contamination of the soils and with the road type, defined by the traffic volume and period of being use. Anova reviled lack of influence of the factors for Cu contents. Unlike Cu, for Cd, Pb and Zn, the significant impact was observed for both factors and interactions between them. The concentrations of Cd, Pb and Zn, regardless of the distance from the road were 0.21–0.58 mg Cd kg−1 d.m., 13.60–41.96 mg Pb kg−1 d.m. and 40.31–63.97 mg Zn kg−1 d.m. In case of increasing distance from the road, generally the contents of Pb, Zn and Cd contents were decreasing. However, only in the case the oldest and carrying the highest traffic road was a clear, statistically significant differences noted for following distances from the road on the content of Cd, Pb and Zn. Analysis of spread gave trend curves, for Pb, Cd and Zn they were parabolas. The curves let reduce sapling distances to 65 m, 45 and 47 m for Cd, Pb and Zn, respectively.
Inertia and propulsion in general relativity: a reply to rodal
Authors: Woodward James F.
Published: February 2020

In a recent issue of this journal, Rodal (Gen Relativ Gravit 51:61–84, 2019) has written an extensive critique of a novel propulsion scheme devised nearly 30 years ago (Woodward in Found Phys Lett 6:1–39, 1995; Making starships and stargates: the science of interstellar transport and absurdly benign wormholes, Springer, New York, 2012). That scheme depends on the production of rest mass fluctuations, driven in special systems, that arise when the systems are accelerated, through the interaction of the systems with the field that produces inertial forces. Following Einstein, the field that produces inertial forces is taken to be the gravitational field due chiefly to the most distant matter (everything that gravitates) in the universe. Such rest mass fluctuations in local accelerating objects, predicted using the relativistic Newtonian approximation to general relativity, are now called “Mach effects” since they depend on inertial forces in fact being gravitational forces as Ernst Mach hinted might be the case. Rodal claims that such rest mass fluctuations with significant magnitude, save in the vicinity of black holes, are not to be found in general relativity notwithstanding that they appear in the relativistic Newtonian approximation. Rodal is mistaken in this claim, as I have already explained at some length (Woodward in J Br Interplanet Soc 70:354–364, 2018). Here I recapitulate some of that material and expand some material with specific reference to his now published claims.
Do Monkeys Avoid Areas of Home Range Overlap Because They Are Dangerous? A Test of the Risk Hypothesis in White-Faced Capuchin Monkeys (Cebus capucinus)
Authors: Tórrez-Herrera Lucía L. , Davis Grace H. , Crofoot Margaret C.
Published: February 2020

In social animals, areas where the home ranges of neighboring groups overlap are often underused. The Risk Hypothesis posits that the costs of intergroup conflict create a “landscape of fear,” discouraging the use of such shared areas. To test this hypothesis, we observed the behavior of white-faced capuchins (Cebus capucinus) in central vs. peripheral areas of their home ranges. If capuchins perceive areas of home range overlap as “risky,” we predicted they would change activity budgets, vocalization rates, and foraging behavior in these areas. A spatially explicit behavioral comparison based on nearly 100 h of focal follows revealed that capuchins socialize less in the periphery (vs. the center) of their home range. Time spent resting, foraging, and engaging in vigilance, as well as vocalization rates, varied in consistent ways across all four study groups, but these differences did not reach statistical significance. Fruit trees near range borders (vs. the center) contained more ripe fruit, and groups spent more time in these trees, with more individuals entering to feed and consuming more fruits. However, capuchins did not alter their foraging behavior in potentially risky peripheral areas in a manner consistent with predictions of optimal foraging theory: intake rates at patch departure were not significantly lower and groups depleted trees to a greater extent along the periphery vs. in the center of their range. These results suggest that while peripheral areas are perceived as risky and this “landscape of fear” contributes to behavioral changes, they also provide resources whose value may outweigh the cost of intergroup encounters.
Deposition of Tungsten Thin Films by Magnetron Sputtering for Large-Scale Production of Tungsten-Based Transition-Edge Sensors
Authors: Abdelhameed A. H. , Angloher G. , Bauer P. , Bento A. , Bertoldo E. , Canonica L. , Fuchs D. , Hauff D. , Iachellini N. Ferreiro , Mancuso M. , Petricca F. , Pröbst F. , Riesch J. , Rothe J.
Published: February 2020

To cope with the foreseen demand for tungsten-based TESs in the current and future phases of the CRESST experiment, we investigated the possibility to implement a reliable, simple and reproducible fabrication method using sputtering. In this contribution, we present the method under development for tungsten deposition using conventional magnetron sputtering with xenon as sputtering gas. TESs with transition temperatures ($$T_c$$Tc) down to 15 mK have been obtained with transition widths smaller than 1 mK. We also give a first assessment on the reproducibility of the process and present the potential for tuning of the $$T_c$$Tc.
Fluctuation Results for General Block Spin Ising Models
Authors: Knöpfel Holger , Löwe Matthias , Schubert Kristina , Sinulis Arthur
Published: February 2020

We study a block spin mean-field Ising model, i.e. a model of spins in which the vertices are divided into a finite number of blocks with each block having a fixed proportion of vertices, and where pair interactions are given according to their blocks. For the vector of block magnetizations we prove Large Deviation Principles and Central Limit Theorems under general assumptions for the block interaction matrix. Using the exchangeable pair approach of Stein’s method we establish a rate of convergence in the Central Limit Theorem for the block magnetization vector in the high temperature regime.
Conformity and Individuals’ Response to Information About Aggregate Turnout
Authors: Blais André , Hortala-Vallve Rafael
Published: February 2020

How do voters react to information about aggregate turnout? Do high turnout levels mobilize or discourage citizens to vote? We argue that it depends on individuals’ degree of conformity. We argue that in addition to the classic calculus of voting, conformist voters have an added incentive to ‘follow the pack’ and vote when turnout is high while abstain when turnout is low. We conduct two separate experiments, the first a survey experiment with a representative sample of the UK population and the second a lab experiment in Canada. Both studies confirm our hypothesis. These findings highlight the importance of taking individuals’ level of conformity into account when explaining their decision to vote or abstain.
Measurement in metrology, psychology and social sciences: data generation traceability and numerical traceability as basic methodological principles applicable across sciences
Authors: Uher Jana
Published: February 2020

Measurement creates trustworthy quantifications. But unified frameworks applicable to all sciences are still lacking and discipline-specific terms, concepts and practices hamper mutual understanding and identification of commonalities and differences. Transdisciplinary and philosophy-of-science analyses are used to compare metrologists’ structural framework of physical measurement with psychologists’ and social scientists’ fiat measurement of constructs. The analyses explore the functions that measuring instruments and measurement-executing persons in themselves fulfil in data generation processes, and identify two basic methodological principles critical for measurement. (1)Data generation traceabilityrequires that numerical assignments depend on the properties to be quantified in the study objects (object-dependence). Therefore, scientists must establish unbroken documented connection chains that directly link (via different steps) the quantitative entity to be measured in the study property with the numerical value assigned to it, thereby making the assignment process fully transparent, traceable and thus reproducible. (2)Numerical traceabilityrequires that scientists also directly link the assigned numerical value to known standards in documented and transparent ways, thereby establishing the results’ public interpretability (subject-independence). The article demonstrates how these principles can be meaningfully applied to psychical and social phenomena, considering their peculiarities and inherent limitations, revealing that not constructs in themselves but only their indicators (proxies) can be measured. These foundational concepts allow to distinguish measurement-based quantifications from other (subjective) quantifications that may be useful for pragmatic purposes but lack epistemic authority, which is particularly important for applied (e.g., legal, clinical) contexts. They also highlight new avenues for establishing transparency and replicability in empirical sciences.
Entrepreneurial ecosystems: a dynamic lifecycle model
Authors: Cantner Uwe , Cunningham James A. , Lehmann Erik E. , Menter Matthias
Published: February 2020

The concept of entrepreneurial ecosystems has been used as a framework to explain entrepreneurial activities within regions and industrial sectors. Despite the usefulness of this approach, the concept is under-theorized, especially with regard to the evolution of entrepreneurial ecosystems. The current literature is lacking a theoretical foundation that addresses the development and change of entrepreneurial ecosystems over time and does not consider the inherent dynamics of entrepreneurial ecosystems that lead to their birth, growth, maturity, decline, and re-emergence. Taking an industry lifecycle perspective, this paper addresses this research gap by elaborating a dynamic entrepreneurial ecosystem lifecycle model. We propose that an ecosystem transitions from an entrepreneurial ecosystem, with a focus on new firm creation, towards a business ecosystem, with a core focus on the internal commercialization of knowledge, i.e., intrapreneurial activities, and vice versa. Our dynamic model thus captures the oscillation that occurs among entrepreneurs and intrapreneurs through the different phases of an ecosystem’s lifecycle. Our dynamic lifecycle model may thus serve as a starting point for future empirical studies focusing on ecosystems and provide the basis for a further understanding of the interrelatedness between and co-existence of new and incumbent firms.
Quasi-realism and normative certitude
Authors: Björkholm Stina , Bykvist Krister , Olson Jonas
Published: February 2020

Just as we can be more or less certain that there is extraterrestrial life or that Goldbach’s conjecture is correct, we can be more or less certain about normative matters, such as whether euthanasia is permissible or whether utilitarianism is true. However, accommodating the phenomenon of degrees of normative certitude is a difficult challenge for non-cognitivist and expressivist views, according to which normative judgements are desire-like attitudes rather than beliefs (Smith, in: Evaluation, Uncertainty, and Motivation. Ethical Theory and Moral Practice 5: 305–320, 2002). Several attempts have been made on behalf of non-cognitivism and expressivism to meet the challenge (Lenman in: Non-cognitivism and the dimensions of evaluative judgment, Brown Electronic Article Review Service, 2003; Ridge in Synthese 2003.10.1007/s11229-018-1884-7; Ridge in: Shafer-Landau (ed) Studies in metaethics, Oxford University Press, Oxford, 2007; Sepielli in Philos Stud 160: 191–207, 2012; Eriksson and Francén Olinder in Aust J Philos 94: 719–735, 2016). These attempts have all been found wanting (Bykvist and Olson in Philos Q 59:202–215, 2009, Aust J Philos 95:794–799, 2017; Bykvist and Olson 2012). Michael Ridge has recently offered a quasi-realist solution, according to which expressivists can say exactly what cognitivists say about certitude, including normative certitude. In this paper, we explain the basic problem and Ridge’s quasi-realist solution. We then argue that the quasi-realist account of normative certitude faces severe difficulties that do not arise for cognitivist accounts, according to which normative judgements are beliefs.
Eco-dialysis: fashion or necessity
Authors: Wieliczko Monika , Zawierucha Jacek , Covic Adrian , Prystacki Tomasz , Marcinkowski Wojciech , Małyszko Jolanta
Published: February 2020

Hemodialysis (HD) is one of the resource hungry medical interventions. A huge volume of water (about 500 L) and significant amounts of energy (over 7 kW) are used for a hemodialysis session; over a kilogram of waste is produced during this procedure. Thus, HD contributes to global warming while saving patients’ lives. In this paper, we showed these crucial points in HD treatment and possible ways (e.g. modifications in dialysate flow rate) to reduce environmental impact maintaining therapy standards.
The art of crafting a systematic literature review in entrepreneurship research
Authors: Kraus Sascha , Breier Matthias , Dasí-Rodríguez Sonia
Published: February 2020

Systematic literature reviews are an increasingly used review methodology to synthesize the existing body of literature in a field. However, editors complain about a high number of desk rejections because of a lack in quality. Poorly developed review articles are not published because of a perceived lack of contribution to the field. Our article supports authors of standalone papers and graduate students in the Entrepreneurship domain to write contribution-focused systematic reviews e.g. by providing a concrete guideline. Our article analyzes the strengths and weaknesses of a systematic literature review and how they can be overcome. Furthermore, we provide a combined list of highly ranked journals in the Entrepreneurship domain as a basis for quality appraisal. Finally, this article builds a scenario for the future of the systematic literature review methodology and shows how technological improvements have changed this methodology and what can be achieved in the future.
Considering Gender-Biased Assumptions in Evolutionary Biology
Authors: Ahnesjö Ingrid , Brealey Jaelle C. , Günter Katerina P. , Martinossi-Allibert Ivain , Morinay Jennifer , Siljestam Mattias , Stångberg Josefine , Vasconcelos Paula
Published: February 2020

Many organisms studied by evolutionary biologists have different sexes, and the evolution of separate sexes and sexual dimorphisms in morphology and behaviour are central questions in evolutionary biology. Considering scientists to be embedded in a social and cultural context, we are also subjected to the risk of gender-biased assumptions and stereotypical thinking to appear when working on topics related to sexual reproduction and sexual dimorphism. Here we present, for continued discussion, a set of good-practice guidelines aimed at (1) helping to improve researchers’ awareness of gender-biased assumptions underlying language use, generalizations, and interpretation of observations; and (2) providing recommendations to increase transparency, avoid problematic terminology, and improve study designs.
Toward Actionable Practice Parameters for “Dual Diagnosis”: Principles of Assessment and Management for Co-Occurring Psychiatric and Intellectual/Developmental Disability
Authors: Constantino John N. , Strom Shae , Bunis Michael , Nadler Cy , Rodgers Teresa , LePage Julia , Cahalan Connie , Stockreef Amber , Evans Lucas , Jones Rachel , Wilson Alyssa
Published: February 2020

Purpose of Review

Although treatment algorithms and parameters for best practice are readily available for all major syndromes of psychiatric impairment, the occurrence of psychiatric syndromes in individuals with intellectual and developmental disability (IDD) invokes serious contextual challenges for interpretation of symptoms, diagnosis, and optimization of treatment, both for clinicians and for the service sectors in which care and support of individuals with IDD are delivered. Recognizing that there exist very few definitive resources for best practice under the circumstance of this form of “dual diagnosis,” the Missouri Department of Mental Health convened an expert panel to conduct a focused review and synthesis of the relevant scientific literature from which to develop guidance in the form of decision support to clinicians. This article summarizes the findings for three of the most common and impairing clusters of psychiatric symptoms that co-occur with IDD—aggression, depression, and addictions.

Recent Findings

Individuals with IDD are at high risk for the development of psychiatric symptoms (PS), which often manifest uniquely in IDD and for which evidence for effective intervention is steadily accruing.

Interventions that are commonly implemented in the IDD service sector (e.g., functional communication training and positive behavioral support planning) are capable of mitigating severe behavioral impairment, yet rarely invoked when dual diagnosis patients are seen in the psychiatric service sector. Conversely, state-of-the-art interventions for traumatic stress, pharmacotherapy, and psychotherapy have proven capable of improving behavioral impairments in IDD but are typically restricted to the psychiatric service sector, where there exist significant barriers to access for patients with IDD, including limitations imposed by diagnostic eligibility and practitioner experience. Bridging these gaps in knowledge and clinical capacity across the respective IDD and PS service sectors should be of very high priority in strategizing the care and support of IDD patients with serious co-occurring psychiatric conditions.
Preparation and Irreversible Inhibition Mechanism Insight into a Recombinant Kunitz Trypsin Inhibitor from Glycine max L. Seeds
Authors: Xu Yanji , Zhang Panpan , Liu Xiao , Wang Zhike , Li Suxia
Published: February 2020

Soybean Kunitz trypsin inhibitor (SKTI), extracted from soybean (Glycine max L.) seeds, possesses insect resistance and anti-tumor properties. But its specific mechanisms of action are not yet known. This article reports an efficient method to produce recombinant SKTI (rSKTI) in Escherichia coli, reveals some biochemical properties of rSKTI, and discusses the inhibition mechanism of SKTI. The rSKTI was expressed as inclusion body in E. coli BL21 (DE3). After refolding, the active rSKTI was obtained and was further purified with anion-exchange chromatography (DEAE-FF) efficiently. There were similar biochemical properties between SKTI and rSKTI. The optimum pH and the optimum temperature were pH 8.0 and 35 °C, respectively, being stable during pH 7.0–11.0 and below 37 °C. The activity against trypsin was inhibited by Co2+, Mn2+, Fe3+, Al3+, and epoxy chloropropane. Inhibition kinetic assay of SKTI against trypsin as Lineweaver-Burk plots analysis both showed an unchanged Km and a decreased Vmax with N-benzoyl-l-arginine ethyl ester (BAEE) as substrate. Molecular modeling showed Arg63 of SKTI (active residue of SKTI) that interacts with four residues of trypsin, including three catalytic site (His57, Asp102, and Ser195) and one binding site (Asp189), forming five interactions. These provide reference for understanding the inhibition mechanism of such kind of Kunitz trypsin inhibitors.
Self-assembly of cellular micro-bio machine parts
Authors: Fahrunnida  , Sayekti Puspa Restu , Nuhamunada Matin , Suyono Eko Agus , Alam Parvez
Published: February 2020

This paper focusses on intra- and inter-species connections between diatoms; hard bioglass microalgae that adhere through the secretion of sticky extracellular polymeric substances (EPS). We identify entirely new diatom attachment mechanisms, and the associated structures that develop from them. Further, we consider these findings in light of potential strategies for the self-assembled manufacture of micro-bio machine parts, and discuss their possible first-order end uses.
ENRICHME: Perception and Interaction of an Assistive Robot for the Elderly at Home
Authors: Coşar Serhan , Fernandez-Carmona Manuel , Agrigoroaie Roxana , Pages Jordi , Ferland François , Zhao Feng , Yue Shigang , Bellotto Nicola , Tapus Adriana
Published: February 2020

Recent technological advances enabled modern robots to become part of our daily life. In particular, assistive robotics emerged as an exciting research topic that can provide solutions to improve the quality of life of elderly and vulnerable people. This paper introduces the robotic platform developed in the ENRICHME project, with particular focus on its innovative perception and interaction capabilities. The project’s main goal is to enrich the day-to-day experience of elderly people at home with technologies that enable health monitoring, complementary care, and social support. The paper presents several modules created to provide cognitive stimulation services for elderly users with mild cognitive impairments. The ENRICHME robot was tested in three pilot sites around Europe (Poland, Greece, and UK) and proven to be an effective assistant for the elderly at home.
Ethical Considerations of Applying Robots in Kindergarten Settings: Towards an Approach from a Macroperspective
Authors: Tolksdorf Nils F. , Siebert Scarlet , Zorn Isabel , Horwath Ilona , Rohlfing Katharina J.
Published: February 2020

In child–robot interaction (cHRI) research, many studies pursue the goal to develop interactive systems that can be applied in everyday settings. For early education, increasingly, the setting of a kindergarten is targeted. However, when cHRI and research are brought into a kindergarten, a range of ethical and related procedural aspects have to be considered and dealt with. While ethical models elaborated within other human–robot interaction settings, e.g., assisted living contexts, can provide some important indicators for relevant issues, we argue that it is important to start developing a systematic approach to identify and tackle those ethical issues which rise with cHRI in kindergarten settings on a more global level and address the impact of the technology from a macroperspective beyond the effects on the individual. Based on our experience in conducting studies with children in general and pedagogical considerations on the role of the institution of kindergarten in specific, in this paper, we enfold some relevant aspects that have barely been addressed in an explicit way in current cHRI research. Four areas are analyzed and key ethical issues are identified in each area: (1) the institutional setting of a kindergarten, (2) children as a vulnerable group, (3) the caregivers’ role, and (4) pedagogical concepts. With our considerations, we aim at (i) broadening the methodology of the current studies within the area of cHRI, (ii) revalidate it based on our comprehensive empirical experience with research in kindergarten settings, both laboratory and real-world contexts, and (iii) provide a framework for the development of a more systematic approach to address the ethical issues in cHRI research within kindergarten settings.