bluuebunny/crossref_metadata_2025 huggingface dataset:
Perception and use of complementary and alternative medicine for low back pain
Authors: Tsang Vivian Hiu Man , Lo Phoebe Hiu Wai , Lam Fong Tao , Chung Lulu Suet Wing , Tang Tin Yan , Lui Hoi Man , Lau Jordan Tsz Gwan , Yee Ho Fung , Lun Yiu Kun , Chan Hei Tung , Cheung Jason Pui Yin
Published: November 2017

Purpose:

To determine the prevalence of complementary and alternative medicine (CAM) use in patients with low back pain (LBP) and to identify its correlation with demographic factors, clinical condition and psychosocial factors.

Methods:

A cross-sectional study was conducted with 278 LBP patients. Use of CAM, demographic parameters and disease duration were determined. Self-reported health status and self-rated scales assessed the effect of disease on quality of life and emotional well-being, respectively. Satisfaction with orthopaedic care and belief partiality towards CAM were assessed.

Results:

In all, 72.3% patients sought CAM treatment. The most common choice of CAM was traditional Chinese medicine (TCM; n = 166), followed by massage therapy ( n = 114) and chiropractic treatment ( n = 45). Within TCM, acupuncture was the most popular treatment for LBP ( n = 127). Only 32.5% patients informed their doctors of their CAM use. In univariate analyses, factors positively associated with CAM use included duration of LBP (odds ratio (OR) = 1.45, 95% confidence interval (CI): 1.06–1.97), use of CAM in close social circles (OR = 1.98, 95% CI: 1.15–3.43) and summary score for belief partiality towards CAM (OR = 1.18, 95% CI: 1.13–1.23). Variables negatively and significantly associated with status of CAM use include age (OR = 0.97, 95% CI: 0.95–0.99) and summary score for satisfaction with orthopaedic care (OR = 0.93, 95% CI: 0.88–0.99).

Conclusion:

CAM use in patients with LBP is prevalent and largely unknown to their doctors. Personal beliefs and their satisfaction with conventional medical treatment both play a part in their decisions to use CAM. Future studies may aim at understanding the effect of CAM on patient adherence to conventional medical treatment and patients’ perception of well-being and pain.
The impact of surgery for trochanteric femur fracture on sexuality in men and their female partners
Authors: Balci Melih , Cankaya Deniz , Tuncel Altug , Yoldas Burak , Guzel Ozer , Senel Cagdas
Published: November 2017

Purpose:

This study was aimed to investigate the effects of trochanteric femur fracture treatment methods on erectile functions of the patients and on sexual functions with their female partners.

Materials and Methods:

A total of 43 patients with trochanteric femur fracture who underwent proximal femoral nail (PFN) or proximal femur locking compression plate (PF-LCP) surgery were included in the study. The PFN implant was applied to group 1 ( n = 23) and the PF-LCP implant to group 2 ( n = 20). All the patients and their female partners completed the 5-item version of the International Index of Erectile Function (IIEF-5) and the Female Sexual Function Index (FSFI) preoperatively and at 1 year postoperatively after the rehabilitation period.

Results:

The mean preoperative IIEF-5 and FSFI score was 21.910.9 and 21.911.1, 72.319.7 and 70.516.2 for the PFN and PF-LCP treatment groups, respectively, and at postoperative 1 year after rehabilitation, change in IIEF-5 score and FSFI score of each group was −6.512.1 versus −3.811.6, ( p < 0.001) and −16110.7 versus −6.314, ( p = 0.001), respectively.

Conclusion:

These data show that trochanteric femur fractures treated with PFN or PF-LCP had a negative impact on sexual function. PF-LCP had a greater negative effect than PFN on sexual function.
Morphological classification of anatomical variants of the intra-articular portion of the long head of the biceps brachii tendon and analysis of the incidence and the relationship with shoulder disease for each subtype
Authors: Jeong Jeung Yeol , Park Seung Min , Park Young Eun , Yoo Jae Chul
Published: November 2017

Purpose:

Although several cases of anatomical variants of the proximal portion of the long head of the biceps brachii tendon have been reported, most are case reports on single patients; few studies have investigated the classification and incidence of this phenomenon. We aimed to classify the variants of the long head of the biceps brachii tendon by their morphology and characterize them in regard to incidence, demography, and the relationship with biceps tendon or other shoulder diseases.

Methods:

We retrospectively reviewed 760 arthroscopic images spanning 31 months from October 2008 and found 45 variations of the proximal portion of the long head of the biceps brachii tendon. We classified the variants using Dierickx classification system and calculated the incidence of each subtype. We investigated age, gender, bicipital morbidity rate, procedure rate, and the frequency of related shoulder disease among the variant groups using patient data and compared the groups to normal patients.

Results:

The overall incidence of variants was 6.5% (67.4%, mesotenon; 32.6%, adherent; 0% split (SPL); and 0% absent (ABS) type). Morbidity and procedure rates of the long head of the biceps (LHB) tendon in the variant group (27.9% and 25.6%, respectively) were lower than in the normal group (40.5% and 38.9%, respectively), but the difference was not statistically significant ( p = 0.102 and 0.082, respectively). Rotator cuff tear was significantly less common in the mesotenon (44.8%) group than in the normal group (62.4%; p = 0.004). Shoulder joint instability was more prevalent in the mesotenon (27.6%) group than in the normal group (14.9%), but the difference was not significant ( p = 0.305). The distribution of other shoulder diseases in the adherent group was similar to that in the normal group.

Conclusions:

The incidence of variants of the long head of the biceps brachii tendon was 6.5%, and most variants were mesotenon or adherent type. The SPL and ABS types were rare. Morbidity and procedure rates of the LHB were not significantly different between the variant group and the normal group, and rotator cuff tear was less common in the mesotenon group.
Evaluation of the Schöttle Technique in the Pediatric Knee
Authors: Huston Kellen L. , Okoroafor Ugochi C. , Kaar Scott G. , Wentt Christa L. , Saluan Paul , Farrow Lutul D.
Published: November 2017

Background:

The Schöttle point is commonly used for anatomic femoral tunnel placement during medial patellofemoral ligament (MPFL) reconstruction. This technique has not been previously validated in the skeletally immature patient, in whom femoral tunnel placement may put the distal femoral physis at risk of iatrogenic injury.

Hypothesis:

Interobserver reliability for femoral tunnel placement will be higher in adult knees compared with pediatric knees.

Study Design:

Cross-sectional study (diagnosis); Level of evidence, 3.

Methods:

We selected 30 perfect lateral radiographs for this study: 20 from pediatric knees (mean patient age, 10 years; range, 8-11 years) and 10 from adult knees (mean patient age, 18.5 years; range, 18-23 years). Six observers with varying levels of clinical experience evaluated each radiograph and approximated the site of the MPFL femoral tunnel using the Schöttle technique. Intra- and interobserver reliabilities for femoral tunnel placement were evaluated. Statistical analysis was used to compare measurements.

Results:

During initial interobserver measurements, the diameter of the composite perfect circles averaged 9.0 and 6.8 mm in adult and pediatric knees, respectively ( P = .004). At repeat measurement, circles averaged 9.8 and 7.3 mm in adult and pediatric knees, respectively ( P = .0001). Femoral tunnel placement intraobserver variance averaged 2.9 mm in adult knees (range, 1.9-4.0 mm) and 2.3 mm in pediatric knees (range, 1.9-2.9 mm). This difference was not significant ( P = .14).

Conclusion:

This study demonstrated that interobserver variance is actually greater in adult knees compared with pediatric knees, although interobserver variance was significantly different for both populations. Additionally, intraobserver variance is small on repeat measures, demonstrating that the Schöttle technique is reproducible for individual observers. Sources of this increased variance between observers are differences in agreement on the bony landmarks required for the Schöttle technique. Due to this variability in tunnel placement, we recommend caution when the Schöttle technique is used in pediatric knees to avoid iatrogenic injury to the distal femoral physis during femoral tunnel placement.
Etonogestrel Implant—To Leave or Stay: A Case Series
Authors: Thew Margaret
Published: November 2017

Long-acting reversible contraception, which include etonogestrel subdermal hormonal implants, has high efficiency rates in preventing teen pregnancy. Although these numbers are increasing, teens have the lowest long-acting reversible contraception usage rate of any group, which the American Congress of Obstetricians and Gynecologists addressed with recommendations for Nexplanon placement for teens. The American Congress of Obstetricians and Gynecologists has recommended support for increased use and training of practitioners and pediatricians to gain momentum. Safety remains a concern as increased usage by practitioners and pediatricians may lead to more adverse outcomes. Despite the improvements to Nexplanon as a preloaded insertion device to prevent deep placement and malalignment, there are few known published adverse outcomes. Although different products, a review of the adverse outcomes reported with Norplant removal may closely reflect today’s concerns with Nexplanon. The 3 case studies in this article are examples of similar adverse outcome with Nexplanon removal as those reported with Norplant.
Prevention Messages in Parent-Infant Bed-Sharing: Message Source, Credibility, and Effectiveness
Authors: Austin Jillian E. , Nashban Chad J. , Doering Jennifer J. , Davies W. Hobart
Published: November 2017

Objective. Despite educational outreach, bed-sharing prevalence is rising. Mothers’ and fathers’ bed-sharing practices, prevention message source, perceived source credibility, and the effectiveness of the prevention message were evaluated. Methods. Data were collected from 678 community parents via an online survey. Results were analyzed using descriptive statistics and phi tests. Results. Bed-sharing reasons focused on comfort and ease. Mothers were more likely to receive prevention messages from individual professionals or organizations, whereas fathers were more likely to hear prevention messages from spouses/coparents and grandfathers. Physicians were the most common source, and physicians and grandmothers were rated as the most credible and effective. Conclusions. Prevention message source varies between mothers and fathers, highlighting the need for continued research with fathers. Grandmothers and physicians are effective and credible sources of prevention messages. Although less frequent, prevention messages from grandmothers were most effective. There was no evidence of effective messages from educational campaigns.
Development and Assessment of a Course to Reduce Weight Bias in Undergraduate Health Promotion Students
Authors: Rote Aubrianne E. , Love Skyler P. , Lakatos Christine M. , Hewitt Lyndi
Published: November 2017

Experiencing discrimination based on body size has numerous health consequences and negatively affects motivation for positive health behaviors. Because weight bias is particularly prevalent among health professionals, interventions to reduce weight bias in this group are essential. The purpose of this mixed-methods, 15-week study was to develop and examine the effect of a college course focused on reducing weight bias in health promotion undergraduates. In this study ( N = 64), quantitative change in implicit and explicit weight bias among students enrolled in a course to reduce weight bias was compared with a control group and two other groups of students in the health promotion degree program. Qualitative data were also analyzed through content analysis of pre- and postsemester writing assignments among students in the course focused on weight bias. Statistical analyses revealed a significant reduction in explicit weight bias among students in the course focused on weight bias with no significant changes in explicit weight bias for any other group. There were no significant changes in implicit weight bias for any group. Content analysis of qualitative data was consistent with the quantitative reductions in extrinsic weight bias. Students shared substantially more nuanced understandings of obesity postsemester. Furthermore, the persistence of internal contradictions in students’ analyses illustrates the particular challenge in reducing implicit bias. These results demonstrate that, although intrinsic weight bias may be more difficult to change, a college course focused on reducing weight bias can facilitate significant reductions in extrinsic weight bias among health promotion undergraduates.
Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice
Authors: Zhou Yuan , Cai Wei , Zhao Zilong , Hilton Tristan , Wang Min , Yeon Jason , Liu Wei , Zhang Fangyi , Shi Fu-Dong , Wu Xiaoping , Thiagarajan Perumal , Li Min , Zhang Jianning , Dong Jing-fei
Published: November 2017

Key Points

Lactadherin promotes the clearance of circulating microvesicles through phagocytosis. Promoting microvesicle clearance prevents coagulopathy, reduces cerebral edema, and improves neurological function in severe TBI mice.
High emergency organ allocation rule in lung transplantation: a simulation study
Authors: Riou Julien , Boëlle Pierre-Yves , Christie Jason D. , Thabut Gabriel
Published: November 2017

The scarcity of suitable organ donors leads to protracted waiting times and mortality in patients awaiting lung transplantation. This study aims to assess the short- and long-term effects of a high emergency organ allocation policy on the outcome of lung transplantation.

We developed a simulation model of lung transplantation waiting queues under two allocation strategies, based either on waiting time only or on additional criteria to prioritise the sickest patients. The model was informed by data from the United Network for Organ Sharing. We compared the impact of these strategies on waiting time, waiting list mortality and overall survival in various situations of organ scarcity.

The impact of a high emergency allocation strategy depends largely on the organ supply. When organ supply is sufficient (>95 organs per 100 patients), it may prevent a small number of early deaths (1 year survival: 93.7% against 92.4% for waiting time only) without significant impact on waiting times or long-term survival. When the organ/recipient ratio is lower, the benefits in early mortality are larger but are counterbalanced by a dramatic increase of the size of the waiting list. Consequently, we observed a progressive increase of mortality on the waiting list (although still lower than with waiting time only), a deterioration of patients’ condition at transplant and a decrease of post-transplant survival times.

High emergency organ allocation is an effective strategy to reduce mortality on the waiting list, but causes a disruption of the list equilibrium that may have detrimental long-term effects in situations of significant organ scarcity.
Reinnervation of the diaphragm by the inferior laryngeal nerve to the phrenic nerve in ventilator-dependent tetraplegic patients with C3-5 damage
Authors: Verin Eric , Morelot-Panzini Capucine , Gonzalez-Bermejo Jesus , Veber Benoit , Perrouin Verbe Brigitte , Soudrie Brigitte , Leroi Anne Marie , Marie Jean Paul , Similowski Thomas
Published: November 2017

The aim of this study was to evaluate the feasibility of unilateral diaphragmatic reinnervation in humans by the inferior laryngeal nerve. This pilot study included chronically ventilated tetraplegic patients with destruction of phrenic nerve motoneurons.

Five patients were included. They all had a high level of tetraplegia, with phrenic nerve motor neuron destruction. They were highly dependent on ventilation, without any possibility of weaning. They did not have other chronic pathologies, especially laryngeal disease. They all had diaphragmatic explorations to diagnose the destruction of the motoneurons of the phrenic nerves and nasoendoscopy to be sure that they did not have laryngeal or pharyngeal disease. Then, surgical anastomosis of the right phrenic nerve was performed with the inferior laryngeal nerve, by a cervical approach. A laryngeal reinnervation was performed at the same time, using the ansa hypoglossi.

One patient was excluded because of a functional phrenic nerve and one patient died 6 months after the surgery of a cardiac arrest. The remaining three patients were evaluated after the anastomosis every 6 months. They did not present any swallowing or vocal alterations. In these three patients, the diaphragmatic explorations showed that there was a recovery of the diaphragmatic electromyogram of the right and left hemidiaphragms after 1 year. Two patients had surgical diaphragmatic explorations for diaphragmatic pacing 18–24 months after the reinnervation with excellent results. At 36 months, none of the patients could restore their automatic ventilation.

In conclusion, this study demonstrated that diaphragmatic reinnervation by the inferior laryngeal nerve is effective, without any vocal or swallowing complications.
RETRACTED ARTICLE: Normal families of solutions for modified equilibrium equations and their applications
Authors: Tan Yili , Ding Weiyong , Wang Yourong , Jiang Zongjing
Published: November 2017

Using boundary behaviors of solutions for certain Laplace equation proved by Yan and Ychussie (Adv. Difference Equ. 2015:226, 2015) and applying a new method to dispose of the impulsive term with finite mass subject presented by Shi and Liao (J. Inequal. Appl. 2015:363, 2015) from another point of view, we prove that there exists a supra-open in $(X,\tau)$
(
X
,
τ
)
for each $V \in\sigma$
V
∈
σ
in which the modified equilibrium equation has normal families of solutions. Moreover, we establish a new expression of a harmonic multifunction for the above equation. As applications, we not only prove the existence of normal families of solutions for modified equilibrium equations but also obtain several characterizations and fundamental properties of these new classes of superharmonic multifunctions.
Statistical methods for mechanical characterization of randomly reinforced media
Authors: Tashkinov Mikhail
Published: November 2017

Advanced materials with heterogeneous microstructure attract extensive interest of researchers and engineers due to combination of unique properties and ability to create materials that are most suitable for each specific application. One of the challenging tasks is development of models of mechanical behavior for such materials since precision of the obtained numerical results highly depends on level of consideration of features of their heterogeneous microstructure. In most cases, numerical modeling of composite structures is based on multiscale approaches that require special techniques for establishing connection between parameters at different scales. This work offers a review of instruments of the statistics and the probability theory that are used for mechanical characterization of heterogeneous media with random positions of reinforcements. Such statistical descriptors are involved in assessment of correlations between the microstructural components and are parts of mechanical theories which require formalization of the information about microstructural morphology. Particularly, the paper addresses application of the instruments of statistics for geometry description and media reconstruction as well as their utilization in homogenization methods and local stochastic stress and strain field analysis.
Reservoir monitoring using borehole radars to improve oil recovery: Suggestions from 3D electromagnetic and fluid modeling
Authors: Zhou Feng , Miorali Mattia , Slob Evert , Hu Xiangyun
Published: November 2017

The recently developed smart well technology allows for sectionalized production control by means of downhole inflow control valves and monitoring devices. We consider borehole radars as permanently installed downhole sensors to monitor fluid evolution in reservoirs, and it provides the possibility to support a proactive control for smart well production. To investigate the potential of borehole radar on monitoring reservoirs, we establish a 3D numerical model by coupling electromagnetic propagation and multiphase flow modeling in a bottom-water drive reservoir environment. Simulation results indicate that time-lapse downhole radar measurements can capture the evolution of water and oil distributions in the proximity (order of meters) of a production well, and reservoir imaging with an array of downhole radars successfully reconstructs the profile of a flowing water front. With the information of reservoir dynamics, a proactive control procedure with smart well production is conducted. This method observably delays the water breakthrough and extends the water-free recovery period. To assess the potential benefits that borehole radar brings to hydrocarbon recovery, three production strategies are simulated in a thin oil rim reservoir scenario, i.e., a conventional well production, a reactive production, and a combined production supported by borehole radar monitoring. Relative to the reactive strategy, the combined strategy further reduces cumulative water production by 66.89%, 1.75%, and 0.45% whereas it increases cumulative oil production by 4.76%, 0.57%, and 0.31%, in the production periods of 1 year, 5 years, and 10 years, respectively. The quantitative comparisons reflect that the combined production strategy has the capability of accelerating oil production and suppressing water production, especially in the early stage of production. We suggest that borehole radar is a promising reservoir monitoring technology, and it has the potential to improve oil recovery efficiency.
Clinical Aspects of SDHA-Related Pheochromocytoma and Paraganglioma: A Nationwide Study
Authors: van der Tuin Karin , Mensenkamp Arjen R , Tops Carli M J , Corssmit Eleonora P M , Dinjens Winand N , van de Horst-Schrivers Anouk N , Jansen Jeroen C , de Jong Mirjam M , Kunst Henricus P M , Kusters Benno , Leter Edward M , Morreau Hans , van Nesselrooij Bernadette M P , Oldenburg Rogier A , Spruijt Liesbeth , Hes Frederik J , Timmers Henri J L M
Published: November 2017

Context

Paraganglioma (PGL) has the highest degree of heritability among human neoplasms. Current clinical understanding of germline SDHA mutation carriers is limited.

Objective

To estimate the contribution of SDHA mutations in PGL and to assess clinical manifestations and age-related penetrance.

Design

Nationwide retrospective cohort study.

Setting

Tertiary referral centers in the Netherlands (multicenter).

Patients

Germline SDHA analysis was performed in 393 patients with genetically unexplained PGL. Subsequently, 30 index SDHA mutation carriers and 56 nonindex carriers were studied.

Main Outcome Measures

SDHA mutation detection yield, clinical manifestations, and SDHA-related disease penetrance.

Results

Pathogenic germline SDHA variants were identified in 30 of the 393 referred patients with PGL (7.6%), who had head and neck PGL (21 of 174 [12%]), pheochromocytoma (4 of 191 [2%]), or sympathetic PGL (5 of 28 [18%]). The median age at diagnosis was 43 years (range, 17 to 81 years) in index SDHA mutation carriers compared with 52 years (range, 7 to 90 years) in nonmutation carriers (P = 0.002). The estimated penetrance of any SDHA-related manifestation was 10% at age 70 years (95% confidence interval, 0% to 21%) in nonindex mutation carriers.

Conclusion

Germline SDHA mutations are relatively common (7.6%) in patients with genetically unexplained PGL. Most index patients presented with apparently sporadic PGL. In this SDHA series, the largest assembled so far, we found the lowest penetrance of all major PGL predisposition genes. This suggests that recommendations for genetic counseling of at-risk relatives and stringency of surveillance for SDHA mutation carriers might need to be reassessed.
Assembly and turnover of neurofilaments in growing axonal neurites
Authors: Boumil Edward F. , Vohnoutka Rishel , Lee Sangmook , Pant Harish , Shea Thomas B.
Published: November 2017

Neurofilaments (NFs) are thought to provide stability to the axon. We examined NF dynamics within axonal neurites of NB2a/d1 neuroblastoma by transient transfection with green fluorescent protein-tagged NF-H (GFP-H) under the control of a tetracycline-inducible promoter. Immunofluorescent and biochemical analyses demonstrated that GFP-H expressed early during neurite outgrowth associated with a population of centrally-situated, highly-phosphorylated crosslinked NFs along the length of axonal neurites (“bundled NFs”). By contrast, GFP-H expressed after considerable neurite outgrowth displayed markedly reduced association with bundled NFs and was instead more evenly distributed throughout the axon. This differential localization was maintained for up to 2 weeks in culture. Once considerable neurite outgrowth had progressed, GFP that had previously associated with the NF bundle during early expression was irreversibly depleted by photobleaching. Cessation of expression allowed monitoring of NF turnover. GFP-H associated bundled NFs underwent slower decay than GFP-H associated with surrounding, less-phosphorylated NFs. Notably, GFP associated with bundled NFs underwent similar decay rates within the core and edges of this bundle. These results are consistent with previous demonstration of a resident NF population within axonal neurites, but suggest that this population is more dynamic than previously considered.
Differential spatial distribution of miR165/6 determines variability in plant root anatomy
Authors: Di Ruocco Giovanna , Bertolotti Gaia , Pacifici Elena , Polverari Laura , Tsiantis Miltos , Sabatini Sabrina , Costantino Paolo , Dello Ioio Raffaele
Published: November 2017

A clear example of interspecific variation is the number of root cortical layers in plants. The genetic mechanisms underlying this variability are poorly understood, partly because of the lack of a convenient model. Here, we demonstrate that Cardamine hirsuta, unlike Arabidopsis thaliana, has two cortical layers that are patterned during late embryogenesis. We show that a miR165/6-dependent distribution of the HOMEODOMAIN LEUCINE ZIPPER III (HD-ZIPIII) transcription factor PHABULOSA (PHB) controls this pattern. Our findings reveal that interspecies variation in miRNA distribution can determine differences in anatomy in plants.
Shep regulates Drosophila neuronal remodeling by controlling transcription of its chromatin targets
Authors: Chen Dahong , Dale Ryan K. , Lei Elissa P.
Published: November 2017

Neuronal remodeling is crucial for formation of the mature nervous system and disruption of this process can lead to neuropsychiatric diseases. Global gene expression changes in neurons during remodeling as well as the factors that regulate these changes remain poorly defined. To elucidate this process, we performed RNA-seq on isolated Drosophila larval and pupal neurons and found upregulated synaptic signaling and downregulated gene expression regulators as a result of normal neuronal metamorphosis. We further tested the role of alan shepard (shep), which encodes an evolutionarily conserved RNA-binding protein required for proper neuronal remodeling. Depletion of shep in neurons prevents the execution of metamorphic gene expression patterns, and shep-regulated genes correspond to Shep chromatin and/or RNA-binding targets. Reduced expression of a Shep-inhibited target gene that we identified, brat, is sufficient to rescue neuronal remodeling defects of shep knockdown flies. Our results reveal direct regulation of transcriptional programs by Shep to regulate neuronal remodeling during metamorphosis.
Homeodomain-interacting protein kinase promotes tumorigenesis and metastatic cell behavior
Authors: Blaquiere Jessica A. , Wong Kenneth Kin Lam , Kinsey Stephen D. , Wu Jin , Verheyen Esther M.
Published: November 2017

Aberrations in signaling pathways that regulate tissue growth often lead to tumorigenesis. Homeodomain-interacting protein kinase (Hipk) family members are reported to have distinct and contradictory effects on cell proliferation and tissue growth. From these studies, it is clear that much remains to be learned about the roles of Hipk family protein kinases in proliferation and cell behavior. Previous work has shown that Drosophila Hipk is a potent growth regulator, thus we predicted that it could have a role in tumorigenesis. In our study of Hipk-induced phenotypes, we observed the formation of tumor-like structures in multiple cell types in larvae and adults. Furthermore, elevated Hipk in epithelial cells induces cell spreading, invasion and epithelial-to-mesenchymal transition (EMT) in the imaginal disc. Further evidence comes from cell culture studies, in which we expressed Drosophila Hipk in human breast cancer cells and showed that it enhances proliferation and migration. Past studies have shown that Hipk can promote the action of conserved pathways implicated in cancer and EMT, such as Wnt/Wingless, Hippo, Notch and JNK. We show that Hipk phenotypes are not likely to arise from activation of a single target, but rather through a cumulative effect on numerous target pathways. Most Drosophila tumor models involve mutations in multiple genes, such as the well-known RasV12 model, in which EMT and invasiveness occur after the additional loss of the tumor suppressor gene scribble. Our study reveals that elevated levels of Hipk on their own can promote both hyperproliferation and invasive cell behavior, suggesting that Hipk family members could be potent oncogenes and drivers of EMT.
A novel fluorescent reporter detects plastic remodeling of mitochondria–ER contact sites
Authors: Yang Zhaoying , Zhao Xiaocui , Xu Jiashen , Shang Weina , Tong Chao
Published: November 2017

Mitochondria–ER contact sites (MERCs) enable communication between the ER and mitochondria and serve as platforms for many cellular events, including autophagy. Nonetheless, the molecular organization of MERCs is not known, and there is no bona fide marker of these contact sites in mammalian cells. In this study, we designed a genetically encoded reporter using split GFP protein for labeling MERCs. We subsequently analyzed its distribution and dynamics during the cell cycle and under stressful cellular conditions such as starvation, apoptosis and ER stress. We found that MERCs are dynamic structures that undergo remodeling within minutes. Mitochondrial morphology, but not ER morphology, affected the distribution of MERCs. We also found that carbonyl cyanidem-chlorophenyl hydrazone (CCCP) and oligomycin A treatment enhanced MERC formation. The stimulations that led to apoptosis or autophagy increased the MERC signal. By contrast, increasing cellular lipid droplet load did not change the pattern of MERCs.
Trehalose metabolism genes render rice white tip nematode, Aphelenchoides besseyi (Nematoda: Aphelenchoididae) resistant to anaerobic environment
Authors: Chen Qiaoli , Wang Feng , Li Danlei , Zhang Ruizhi , Ling Yaming
Published: November 2017

After experiencing anaerobic environments, Aphelenchoides besseyi will enter a state of suspended animation known as anoxybiosis, which may use trehalose for energy supply to survive. To identify the function of trehalose metabolism, two trehalose-6-phosphate synthase (TPS) genes (Ab-tps1 and Ab-tps2) encoding enzymes catalyzing trehalose synthesis and three trehalase (TRE) genes (Ab-ntre1, Ab-ntre2 and Ab-atre) encoding enzymes catalyzing the hydrolysis of trehalose were identified and investigated. Ab-tps1 and Ab-tps2 were active when A. besseyi was during certain periods of anoxybiosis and Ab-tps2, Ab-ntre1, Ab-ntre2 and Ab-atre were active when A. besseyi was during certain periods of recovery. The results of RNA interference experiments suggested that TRE genes regulated each other and both TPS genes; while a single TPS gene only regulated the other TPS gene but two TPS genes together could regulate TRE genes, which indicated a feedback mechanism between these genes. All these genes also positively regulated the survival and the resumption of active metabolism of the nematode. Whereas, genes functioning at reaeration impact more on nematode survival, revealing that these genes should play roles in anoxybiosis regulation but may function within restricted time frames. The quantity of trehalose level and TRE activity were complementary during the anoxybiosis-reaeration process, manifesting that trehalose may act as an energy supply source. The observation of obviously up-regulations of TPS genes during anoxybiosis suggested a possible signal role of trehalose. Also trehalose metabolism genes were supposed to work together to control trehalose level to a certain magnitude when the nematode was under anaerobic environment.
Exercise and the Tumor Microenvironment: Potential Therapeutic Implications
Authors: Wiggins Jennifer M. , Opoku-Acheampong Alexander B. , Baumfalk Dryden R. , Siemann Dietmar W. , Behnke Bradley J.
Published: November 2017

An imbalance in oxygen delivery to demand in solid tumors results in local areas of hypoxia leading to poor prognosis for the patient. We hypothesize that aerobic exercise increases tumor blood flow, recruits previously nonperfused tumor blood vessels, and thereby augments blood-tumor O2 transport and diminishes tumor hypoxia. When combined with conventional anticancer treatments, aerobic exercise can significantly improve the outcomes for several types of cancers.
Increased static postural sway after energy drink consumption: A randomized trial
Authors: Rosario Martin G. , Collazo Henry , Mateo Milagros , Gonzalez-Sola Maryví , Bayron Flavia
Published: November 2017

Background: Energy drinks consumption continues to grow since its appearance in the United States in 1997. Available evidence indicates that caffeine, their main ingredient, can alter the central nervous system (CNS). However, it is unknown how energy drinks alter the CNS postural control mechanism. The purpose of this study was to investigate how energy drinks can affect postural control after sensory perturbations during stance.

Methods: 20 healthy adults, (11 males; 9 females) averaging 26.1 years of age, stood on a MatScan™ pressure mat, which measured center of pressure (CoP), anteroposterior (AP) and mediolateral (ML) postural sways during eight different balance tests (BALT’s). BALT's were designed to alter or cancel the systems involved in postural control: visual, vestibular and somatosensory. Subjects were randomly assigned to a caffeine group and an energy drink group. MANOVA analysis was performed for all variables of interest.

Results: In the caffeine group, the AP sway of the Eyes Closed test on a stable surface was statistically significant. In the energy drinks group, we observed a general tendency of participants to increase CoP slightly, AP and ML sway in most of the BALT’s after the consumption of an energy drink. However, this increase was not statistically significant. These results suggest that in healthy young adults, the sensory re-weighting mechanism can overcome postural perturbation and maintain overall postural control.

Conclusions: We observed an overall tendency to increase postural instability after the ingestion of energy drinks.
Predicted protein interactions of IFITMs may shed light on mechanisms of Zika virus-induced microcephaly and host invasion
Authors: Ganapathiraju Madhavi K. , Karunakaran Kalyani B. , Correa-Menéndez Josefina
Published: November 2017

After the first reported case of Zika virus (ZIKV) in Brazil, in 2015, a significant increase in the reported cases of microcephaly was observed. Microcephaly is a neurological condition in which the infant’s head is significantly smaller with complications in brain development. Recently, two small membrane-associated interferon-inducible transmembrane proteins (IFITM1 and IFITM3) have been shown to repress members of the flaviviridae family which includes ZIKV. However, the exact mechanisms leading to the inhibition of the virus are yet unknown. Here, we assembled an interactome of IFITM1 and IFITM3 with known protein-protein interactions (PPIs) collected from publicly available databases and novel PPIs predicted using the High-confidence Protein-Protein Interaction Prediction (HiPPIP) model. We analyzed the functional and pathway associations of the interacting proteins, and found that there are several immunity pathways (toll-like receptor signaling, cd28 signaling in T-helper cells, crosstalk between dendritic cells and natural killer cells), neuronal pathways (axonal guidance signaling, neural tube closure and actin cytoskeleton signaling) and developmental pathways (neural tube closure, embryonic skeletal system development) that are associated with these interactors. Our novel PPIs associate cilia dysfunction in ependymal cells to microcephaly, and may also shed light on potential targets of ZIKV for host invasion by immunosuppression and cytoskeletal rearrangements. These results could help direct future research in elucidating the mechanisms underlying host defense to ZIKV and other flaviviruses.
Understanding and improving multi-sectoral partnerships for chronic disease prevention: blending conceptual and practical insights
Authors: Willis Cameron , Greene Julie , Riley Barbara
Published: November 2017

Inter-organisational partnerships are widely used approaches in public health and chronic disease prevention (CDP), and may include organisations from different sectors, such as research-policypractice sectors, inter-governmental sectors, or public and private sectors. While multiple conceptual frameworks related to multi-sectoral partnerships exist, they do not reflect the interactions among key factors that influence the performance of partnerships, including those involving public-private partners for CDP. Using system mapping, this project sought to propose potential linkages among factors that influence multi-sectoral partnerships through blending insights from conceptual frameworks with the experiences of a government agency involved in brokering multi-sectoral partnerships for CDP.
Family-Professional Partnerships Within Schoolwide Positive Behavior Interventions and Support (SWPBIS): Preliminary Evidence for the Partnering for Positive Behavior (PPB) Meeting Strategy
Authors: Kyzar Kathleen B. , Strickland-Cohen M. Kathleen
Published: November 2017

Schoolwide Positive Behavior Interventions and Support (SWPBIS) has been shown to be effective in improving prosocial student behaviors, which increases the likelihood of inclusive placements for students within school settings. However, to date, the SWPBIS model has lacked research-based knowledge about partnership-oriented family engagement practices that involve families and educators of students with mild to moderate problem behavior (i.e., problem behavior that does not require intensive, individualized intervention) using shared decision making to address student behavioral outcomes across home and school settings. This article reports the results of a pilot study examining Partnering for Positive Behavior (PPB), a partnership-oriented teacher-family member meeting strategy designed to address the needs of students struggling to meet classwide behavioral expectations. Participants were five educators in elementary and middle school settings. Data were analyzed utilizing a qualitative approach to generate themes. Results suggested participants and family members addressed positively stated behavioral expectations and defined them in a similar manner across the home and school settings. Overall, participants were satisfied with the PPB process, especially the strengths-based aspect of the meeting, and they judged PPB as usable and feasible given their current resources. Discussion and implications of these findings are offered.
Individual and Family Correlates of Community Living Options Among Adults With Intellectual and Developmental Disabilities
Authors: Burke Meghan M. , Lee Chung eun , Chung Moon Y. , Rios Kristina , Arnold Catherine K. , Owen Aleksa
Published: November 2017

With recent policy changes and case-law decisions, there are more opportunities for adults with intellectual and developmental disabilities (IDD) to live independently in inclusive settings. It is necessary to identify malleable correlates of community living options to develop interventions to increase inclusive, independent living. To this end, 546 parents and siblings of adults with IDD responded to a national survey. According to parent and sibling report, adults with IDD were more likely to live outside of the family home when the family engaged in future planning, the individual had more informal supports and more functional abilities and had parents with fewer caregiving abilities. Among the 187 adults with IDD who lived outside of the family home, individuals with more problem behaviors and fewer functional abilities were more likely to live in larger group homes (versus independently with or without supports). Further, when the family engaged in more future planning activities, adults with disabilities were more likely to live in a group home (versus independently). When parents had fewer caregiving abilities, adults with disabilities were more likely to live in bigger group homes (versus independently). Implications for policymakers, practitioners, and research are discussed.
In-corporeal diagrams: Drawing from dance to architecture
Authors: Charron Renée
Published: November 2017

This article is one of the offsprings of an ongoing enquiry that set out to revisit drawing’s role in architecture, by weaving a field of relations between pedagogical and epistemological theories of dance, drawing and architecture. The theories situate the affective/haptic kinaesthetic body at the centre of all in-corporeal experience, perception and conception. This article examines drawing’s potential to revive the body in architectural practices, by unveiling forces and processes that compose bodies and intertwine with the corporeality of architecture. It establishes drawing as a form of dance capable of inscribing the kinaesthetic vitality of the body into architecture. It examines architect Frank Gehry’s sketches as dynamic tracings of embodied gestures and bodily logos that mediate body and environment, interior and exterior.
Reviews
Authors: Thackara Davina , Lloyd Peta
Published: November 2017

Drawing and Dialogue, Deanna Petherbridge (2016) London: Circa Press, 191 pp., ISBN: 9780993072154, h/bk, £24.95

Draw to Perform 3, Crows Nest Gallery, London, 30–31 July 2016
PERFIL DAS PROPRIEDADES LEITEIRAS PERTENCENTES AO PROGRAMA CURRAL BONITO DO MUNICÍPIO DE RIO POMBA, MG
Authors: Cruz Melo Iago Lúcio , Araújo Teixeira Rafael Monteiro
Published: November 2017

O objetivo do presente estudo foi avaliar os índices zootécnicos e a qualidade do leite de produtores pertencentes ao programa Curral Bonito. O experimento foi realizado durante os meses de março a outubro de 2016, utilizando-se 17 propriedades leiteiras localizadas no município de Rio Pomba, pertencente à mesorregião da Zona da Mata Mineira. A avaliação consistiu na aplicação de um questionário, para levantamento da propriedade. Os itens avaliados foram parâmetros de composição (% gordura e proteína), padrões higiênico-sanitários (contagem de células somáticas – CCS) e índices zootécnicos. Foram constatados que os teores de gordura e proteína estavam dentro do padrão permitido pela IN62. Em relação à CCS, foram encontrados valores acima dos limites permitidos pela legislação. Ao diagnosticar o perfil das propriedades, verificou-se que os produtores pertencentes ao programa Curral Bonito necessitam além da melhoria do potencial genético dos animais, o acompanhamento por assistência técnica especializada, com adoção de estratégias capazes de reduzir os custos de produção, aumentando a produtividade e consequentemente a lucratividade da propriedade.
A research on fluent reading skills of secondary school students
Authors: Türkyılmaz Mustafa
Published: November 2017

The study aims to determine the relationship of reading fluency skills of secondary school students and level of using social media sites, reading attitudes and reading self-competence perceptions, and whether fluent reading skills of students vary depending on text genres. In this context, texts of different genres were read to 112 secondary school students. Oral readings of each text by students were recorded. These records were resolved by the researcher. Incorrectly read and skipped words were identified, and it was determined how many words were read without error in three minutes. In addition, each student marked for Reading Attitude Scale, Reading Self-Competence Perception Scale, and Facebook Addiction Scale. As a result of the study, it was determined that all of text genres were read different pacing. Moreover, a significant and positive relationship is observed between text-reading speeds. A positive relationship is observed between perceptions of students relating to their competence as readers and reading speed and attitude. It can be said that individuals with increased Facebook addiction level have decreased self-competence perceptions relating to reading. In other words, it may be said that reading competences of participants are affected negatively as addiction to Facebook social media sites increases.