bluuebunny/crossref_metadata_2025 huggingface dataset:
Greater Ecologically Assessed Positive Experiences Predict Heightened Sex Hormone Concentrations Across Two Weeks in Older Adults
Authors: Knight Erik L , Graham-Engeland Jennifer E , Sliwinski Martin J , Engeland Christopher G
Published: January 2023

Objectives

Sex hormones are important components of healthy aging, with beneficial effects on physical and mental health. Positive experiences such as elevated mood, lowered stress, and higher well-being also contribute to health outcomes and, in younger adults, may be associated with elevated sex hormone levels. However, little is known about the association between positive experiences and sex hormones in older adults.

Methods

In this study, older men and women (N = 224, 70+ years of age) provided blood samples before and after a 2-week period of ecological momentary assessment (EMA) of positive and negative experiences (assessed based on self-reporting items related to affect, stress, and well-being). Concentrations of a panel of steroid sex hormones and glucocorticoids were determined in blood.

Results

Higher levels of positive experiences reported in daily life across 2 weeks were associated with increases in free (biologically active) levels of testosterone (B = 0.353 [0.106, 0.601], t(221.3) = 2.801, p = .006), estradiol (B = 0.373 [0.097, 0.649], t(225.1) = 2.645, p = .009), and estrone (B = 0.468 [0.208, 0.727], t(224.3) = 3.535, p < .001) between the start and the end of the 2-week EMA period.

Discussion

These findings suggest that sex hormones may be a pathway linking positive experiences to health in older adults.
Refining the Moho across the Australian continent
Authors: Kennett B L N , Gorbatov A , Yuan H , Agrawal S , Murdie R , Doublier M P , Eakin C M , Miller M S , Zhao L , Czarnota K , O’Donnell J P , Dentith M , Gessner K
Published: January 2023

In recent years, there has been a considerable expansion of deployments of portable seismic stations across Australia, which have been analysed by receiver function or autocorrelation methods to extract estimates of Moho depth. An ongoing program of full-crustal reflection profiles has now provided more than 25 000 km of reflection transects that have been interpreted for Moho structure. The Moho data set is further augmented by extensive marine reflection results. These new data sources have been combined with earlier refraction and receiver function results to provide full continental coverage, though some desert areas remain with limited sampling. The dense sampling of the Moho indicates the presence of rapid changes in Moho depth, and so, the Moho surface has been constructed using an approach that allows different weighting and spatial influence depending on the nature of the estimate. The inclusion of Moho results from continental-wide gravity inversion with low weighting helps to resolve the continent-ocean transition and to provide additional control in the least sampled zones. The refined distribution indicates the presence of widespread smaller-scale variations in Moho structure. Strong lateral contrasts in crustal thickness remain, but some have become more subdued with improved sampling of critical areas. The main differences from earlier results lie in previously poorly sampled regions around the Lake Eyre Basin, where additional passive seismic results indicate somewhat thicker crust though still with a strong contrast in crustal thickness to the cratonic zone to the west.
Resolving minute temporal seismic velocity changes induced by earthquake damage: the more stations, the merrier?
Authors: Illien Luc , Sens-Schönfelder Christoph , Ke Kuan-Yu
Published: January 2023

Ground shaking induced by earthquakes often introduces transient changes in seismic velocity monitored with ambient noise. These changes are usually attributed to relaxation behaviour following the coseismic damage in the subsurface and are of relevance for post-seismic hazard mitigation. However, the velocity evolution associated with this phenomenon can occur at very small timescales and amplitudes that are not resolved with seismic interferometry and are therefore challenging to link to laboratory experiments. A way to improve the temporal resolution of the velocity time-series is to test whether the estimation of the relative seismic velocity changes dv/v obeys the ergodic hypothesis in which the joint use of colocated stations would lead to better resolved measurements. In this study, we present results from a dense seismic array that was deployed for 2 weeks at the remarkable Patache site in Chile. Thanks to high temporal averaging capabilities, we are able to resolve seismic velocity changes in the 3–6 Hz frequency band at a 10-min resolution around the occurrence of a moderate earthquake (PGV ∼1 cm s–1). We report a velocity drop of ∼0.4 per cent in the first 10 min after ground shaking. Half of this initial drop was recovered within the 2 following days. The shape of the recovery follows a log-linear shape over the whole observed recovery phase, analogous to slow dynamics experiments. When normalized by the total amount of processed data, we show that the ergodic hypothesis almost perfectly holds in our network: the dv/v signal-to-noise ratio (SNR) obtained when averaging a few observation with large stacking durations for the correlation functions is almost equal to the SNR when using a large number of observations with small stacking durations. To understand if the ergodicity is linked to a particular site property, we use the array capabilities to identify the surf at the shoreline as the source of the noise and to derive a 1-D shear velocity profile with the focal spot imaging technique and a transdimensional Bayesian inversion framework. The inversion shows that hard rocks lie close to the surface indicating that this material hosts the observed shallow velocity changes. We discuss our high-resolution measurements and attribute them to a stable noise source excited by the shore, the ergodicity property and an ideal subsurface structure. Finally, we discuss the effect of moderate earthquakes on subsurface damage and the potential relaxation processes in hard rocks.
Ad hoc coalitions in global governance: short-notice, task- and time-specific cooperation
Authors: Reykers Yf , Karlsrud John , Brosig Malte , Hofmann Stephanie C , Maglia Cristiana , Rieker Pernille
Published: January 2023

Ad hoc coalitions (AHCs) are an indispensable but scantly conceptualized part of global governance. In recent years, several typologies and classifications of global governance arrangements have been provided, mostly differentiating them based on their organizational design features of degree of formality and membership composition. These do not capture AHCs and the role they play in global governance. In this article, we not only provide a conceptualization of AHCs, but also propose ways in which AHCs fit within the broader global governance architecture. We argue that what sets AHCs apart is not so much their (in)formality or membership, but rather their short-notice creation, their task-specific purpose and their temporarily circumscribed existence. We therefore define AHCs as autonomous arrangements with a task-specific mandate established at short notice for a limited time frame. We then develop a research agenda on the nature and future of AHCs, including their short- and long-term relationship with other multilateral arrangements in the global governance architecture. This is important, as we do yet not know how AHCs complement, compete and impact on international organizations and international crisis response.
Desde el neoliberalismo austericida de Europa hacia la reconstrucción social en España: propuestas para la reforma constitucional
Authors: Montesinos Padilla Carmen
Published: January 2023

More than a decade after the start of the eurozone crisis, the coronavirus in Spain has brought back the idea of constitutional reform in social rights. The paradigm shift that occurred with the arrival of the pandemic is hardly questionable. From the austerity promoted by European institutions and assumed by national authorities in the face of the 2008 financial crisis, we have recently moved on to boosting public investment and social spending in both spheres of governance. This paper comparatively analyses the two scenarios to demonstrate that economic policy is a matter of ideology. Moreover, austerity is only one of many possible responses to economic downturns. And to preserve our welfare state in the face of future austerity trends, this paper argues strongly in favour of a series of constitutional reforms in Spain to guarantee the effectiveness of social rights.
Graph metric learning quantifies morphological differences between two genotypes of shoot apical meristem cells inArabidopsis
Authors: Scott Cory Braker , Mjolsness Eric , Oyen Diane , Kodera Chie , Uyttewaal Magalie , Bouchez David
Published: January 2023

We present a method for learning ‘spectrally descriptive’ edge weights for graphs. We generalize a previously known distance measure on graphs (graph diffusion distance [GDD]), thereby allowing it to be tuned to minimize an arbitrary loss function. Because all steps involved in calculating this modified GDD are differentiable, we demonstrate that it is possible for a small neural network model to learn edge weights which minimize loss. We apply this method to discriminate between graphs constructed from shoot apical meristem images of two genotypes of Arabidopsis thaliana specimens: wild-type and trm678 triple mutants with cell division phenotype. Training edge weights and kernel parameters with contrastive loss produce a learned distance metric with large margins between these graph categories. We demonstrate this by showing improved performance of a simple k-nearest-neighbour classifier on the learned distance matrix. We also demonstrate a further application of this method to biological image analysis. Once trained, we use our model to compute the distance between the biological graphs and a set of graphs output by a cell division simulator. Comparing simulated cell division graphs to biological ones allows us to identify simulation parameter regimes which characterize mutant versus wild-type Arabidopsis cells. We find that trm678 mutant cells are characterized by increased randomness of division planes and decreased ability to avoid previous vertices between cell walls.
The accuracy of the Global Trigger Tool is higher for the identification of adverse events of greater harm: a diagnostic test study
Authors: Moraes Sara Monteiro , Ferrari Teresa Cristina Abreu , Beleigoli Alline
Published: January 2023

Global Trigger Tool (GTT) of the Institute for Healthcare Improvement (IHI) has been used as a measurement strategy for patient safety by several institutions and national programs. Although the greater ability of the GTT to identify adverse events (AEs) compared to other methods has already been demonstrated, there are few data on its accuracy, and studies suggest lower sensitivity for minor AEs. This study aimed to assess the accuracy of the GTT for identifying AEs in adult inpatients for all AEs and for the subgroup of AEs with greater harm to the patient, classified as F–I on the IHI-GTT adapted version of the National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP) Index for Categorizing Errors. In this diagnostic test study, GTT is the index test and identification of AEs (yes/no) represents the condition of interest. Due to the lack of a gold standard test, a composite reference standard method was developed. Reference standard method combined real-time (during hospitalizations) and retrospective search of medical records and administrative data for screening criteria and AEs. Both tests were applied to a random sample of 211 hospitalizations of adult inpatients during October–November 2016 in a large public hospital in Belo Horizonte, Brazil. The accuracy of the GTT was evaluated using sensitivity, specificity, and global accuracy. A total of 176 AEs were identified in 67 admissions using reference standard method and 129 AEs in 76 admissions using GTT, resulting in rates of 126 and 93 AEs/1000 patient-days, respectively. Sensitivity, specificity, and global accuracy of the GTT for the identification of individual AEs were, respectively, 0.41 (95% confidence interval [CI] 0.34; 0.49), 0.68 (95% CI 0.60; 0.74), and 0.54 (95% CI 0.49; 0.60) for all AEs, regardless of the harm categorization, and 0.85 (95% CI 0.72; 0.93), 0.88 (95% CI 0.82; 0.92), and 0.87 (95% CI 0.82; 0.91) for the subgroup of AEs categorized as harm F–I. Among the main AEs missed by the GTT are AEs related to nursing care, such as those related to peripheral venous access and gastric/enteric catheters. GTT proved to be a valid method for identifying AEs in adult inpatients. Its accuracy increases when minor harm AEs are not counted. Among the main AEs missed by the GTT are those related to nursing care. Therefore, the GTT should be used in conjunction with other measurement strategies to achieve results that are representative of the quality profile of the care provided and, thus, guide the best improvement strategies.
The influence of a probiotic/prebiotic supplement on microbial and metabolic parameters of equine cecal fluid or fecal slurry in vitro
Authors: MacNicol Jennifer L , Renwick Simone , Ganobis Caroline M , Allen-Vercoe Emma , Weese Jeffery S , Pearson Wendy
Published: January 2023

The microbes that reside within the equine hindgut create a complex and dynamic ecosystem. The equine hindgut microbiota is intimately associated with health and, as such, represents an area which can be beneficially modified. Synbiotics, supplements that combine probiotic micro-organisms with prebiotic ingredients, are a potential means of influencing the hindgut microbiota to promote health and prevent disease. The objective of the current study was to evaluate the influence of an equine probiotic/prebiotic supplement on characteristics of the microbiota and metabolite production in vitro. Equine cecal fluid and fecal material were collected from an abattoir in QC, CAN. Five hundred milliliters of cecal fluid was used to inoculate chemostat vessels maintained as batch fermenters (chemostat cecal, N = 11) with either 0 g (control) or 0.44 g of supplement added at 12 h intervals. One hundred milliliters of cecal fluid (anaerobic cecal, N = 15) or 5% fecal slurry (anaerobic fecal, N = 6) were maintained in an anaerobic chamber with either 0 g (control) or 0.356 g of supplement added at the time of vessel establishment. Samples were taken from vessels at vessel establishment (0), 24, or 48 h of incubation. Illumina sequencing of the V4 region of the 16S rRNA gene and bioinformatics were performed for microbiome analysis. Metabolite data was obtained via NMR spectroscopy. All statistical analyses were run in SAS 9.4. There was no effect of treatment at 24 or 48h on alpha or beta diversity indices and limited taxonomic differences were noted. Acetate, propionate, and butyrate were higher in treated compared to untreated vessels in all methods. A consistent effect of supplementation on the metabolic profile with no discernable impact on the microbiota of these in vitro systems indicates inoculum microbe viability and a utilization of the provided fermentable substrate within the systems. Although no changes within the microbiome were apparent, the consistent changes in metabolites indicates a potential prebiotic effect of the added supplement and merits further exploration.
An in vitro and in vivo approach to characterize digesta from pigs fed different forms of pea flour
Authors: Grundy Myriam M L , Labarre Julien , Mayeur-Nickel Frederique , van Milgen Jaap , Renaudeau David
Published: January 2023

In vitro models of digestion are useful tools to explore the behavior of dietary fiber sources in gastrointestinal conditions. To evaluate the validity of our digestion model, digesta obtained in vivo and in vitro were characterized and the impact of cell wall integrity on protein bioaccessibility and digestibility evaluated. Six cannulated barrows [Pietrain × (Large White × Landrace)] were included in a 2 × 2 Latin square design where they were fed two diets identical in chemical composition but differing in nutrient bioaccessibility. Pea was given either as flour (R1, most proteins encapsulated by intact cell walls) or reconstituted flour (R2, mixture of proteins and purified, broken cell walls). Digesta were collected at the duodenal and ileal cannulas at regular interval and after slaughtering, following ingestion of either R1 or R2. The two diets were also digested in vitro using a static gastrointestinal model. The original pea ingredients as well as the digesta collected in vivo and in vitro were characterized (i.e., particle size measurement, microscopy observations and gel electrophoresis) and then compared with each other. The degradation of the pea ingredients differed greatly between the two forms of flour, where particles filled with nutrients were recovered at the latest stage of R1 intestinal digestion as observed with the particle size distribution and the microscopy images. These results were consistent with the in vivo and in vitro digestibility analysis that showed lower protein hydrolysis for R1 than that for R2 (about 19% difference in protein digestion regardless of the method). Overall, great similarities were found between the digesta collected in vivo and in vitro, especially regarding the particle size measurements. To summarize, a substantial proportion of the proteins contained in R1 was retained within the pea cells following gastrointestinal digestion. These encapsulated proteins reduced the amount of amino acids and small peptides available for absorption. This mechanism will have consequences on postprandial metabolism of amino acids and bacterial population based on the delivery form of the dietary fiber.
A Review of Petrol Burns in Australia and New Zealand
Authors: Savage Nicholas , Doherty Zakary , Singer Yvonne , Menezes Hana , Cleland Heather , Goldie Stephen J
Published: January 2023

Petrol-related thermal burns cause significant morbidity and mortality worldwide and it has been established that they affect young males disproportionately. Beyond this, we sought to identify the difference in the characteristics and outcomes of burns between males and females in an international population. Such differences may highlight areas for future preventative strategies. The Burns Registry of Australia and New Zealand was used. Petrol burns that resulted in a hospital admission in those 16 years or older between January 2010 and December 2019 were included. A total of 2833 patients were included. The median age was 35 years with most patients being male (88%). Burns from a campfire or burnoffs were most common. Females were more likely to suffer burns due to assault or from deliberate self-harm. The total body surface area affected by burns was higher for females than males (10% vs 8%). Furthermore, females more frequently required ICU admission, escharotomies, and had a longer hospital length of stay. The unadjusted mortality rate for females was more than double the rate for males (5.8% vs 2.3%). This international study demonstrates that whilst men more frequently suffer petrol burns, women suffer more severe burns, require more intensive and longer hospitalizations and have a higher mortality rate. These findings may inform changes in preventative health policies globally to mitigate against these concerning findings.
Examination of Hivetop Incubator Efficacy for Emerging Osmia lignaria (Hymenoptera: Megachilidae) and the Impact on Apis mellifera (Hymenoptera: Apidae) Colonies
Authors: McCabe Lindsie M , Cox-Foster Diana , Pitts-Singer Theresa L
Published: January 2023

Osmia lignaria Say is used in combination with Apis mellifera L. to pollinate U.S. orchard crops. The deployment of O. lignaria requires artificial warming to synchronize adult bee emergence with crop bloom. However, current methods for emerging bees are time consuming and inefficient; the Hivetop Incubator (HTI) invention creates a space atop an A. mellifera hive whose heat flows through the screened bottom of the HTI to incubate cocooned O. lignaria adults therein. In response to HTI heat, O. lignaria adults chew out of cocoons, find an exit hole, and fly away to nest in provided nesting sites and, thereby, pollinate a crop. Objectives for studies performed in Utah and Washington were to: 1) determine whether HTIs inhibit A. mellifera thermoregulation or colony growth, 2) compare O. lignaria emergence duration from an HTI with and without hive heat, and 3) assess whether O. lignaria females leave HTIs located at the orchard edge to nest throughout the orchard. We found no significant differences between the internal temperatures of A. mellifera colonies with and without HTIs and no impact on A. mellifera food storage or brood production. Osmia lignaria in hive-heated HTIs emerged 3× faster than bees in unheated HTIs. Heated HTIs were significantly cooler than hive temperatures but significantly warmer than HTIs atop empty hive boxes. Osmia lignaria nest distribution was not correlated to the location of HTIs at the orchard edge. Overall, HTIs were effective for timely, on-site emergence of O. lignaria for orchard pollination without negatively impacting A. mellifera colonies.
Anthropogenic Influence on the Distribution of the Longlegged Ant (Hymenoptera: Formicidae)
Authors: Lum Jun-Yin , Chiu Ming-Chung , Tseng Shu-Ping , Scotty Yang Chin-Cheng , Lee Chow-Yang
Published: January 2023

The longlegged ant Anoplolepis gracilipes (Smith) is a highly invasive tramp ant species known for its deleterious effects on native ecosystems. While tramp ants are associated with human activity, information on how different intensities of human activity affect their distribution is limited. This study investigated how anthropogenic activities affected the distribution of A. gracilipes in Penang, a tropical island in northern peninsular Malaysia. Three study sites (Youth Park, Sungai Ara, and Bukit Jambul/Relau) were selected, containing four sub-locations corresponding to different levels of human activity (low, moderate, high, and very high), determined by the average number of passersby observed over 30 min. Baited index cards were placed at each sub-location to evaluate ant abundance and distribution. The results demonstrated that A. gracilipes worker abundance was highest in areas of moderate human activity, as opposed to areas with low and higher human activity. The low abundance of A. gracilipes in comparatively undisturbed localities may be attributed to unsuitable microclimate, lack of propagule pressure, and diminished honeydew availability. In contrast, its exclusion from more urbanized localities could be explained by high interspecific competition with other tramp species and the absence of preferred nesting sites.
Internalized transphobia predicts worse longitudinal trend of body uneasiness in transgender persons treated with gender affirming hormone therapy: a 1-year follow-up study
Authors: Castellini Giovanni , Rossi Eleonora , Cassioli Emanuele , Sanfilippo Giulia , Ristori Jiska , Vignozzi Linda , Maggi Mario , Ricca Valdo , Fisher Alessandra Daphne
Published: January 2023

Background

Given the relationship between interiorized stigma and body image, it could be hypothesized that high levels of internalized transphobia (IT) might predict higher levels of body uneasiness in subjects with gender dysphoria (GD) and worse improvement of body image after gender affirming hormone therapy (GAHT).

Aim

We sought to evaluate the relationship between IT and body uneasiness in subjects with GD and the role of IT in moderating the improvement of body image after GAHT.

Methods

In total, 200 individuals with GD performed the baseline assessment; 99 were re-evaluated 12 months after starting GAHT. At baseline participants were evaluated through a face-to-face interview and filled self-administered questionnaires to evaluate GD (Utrecht Gender Dysphoria Scale [UGDS]), IT attitudes (Attitudes Toward Transgendered Individuals [ATTI] Scale), body uneasiness (Body Uneasiness Test, part A [BUT-A]), and general psychopathology (Symptom Checklist 90-Revised [SCL 90-R]). The same questionnaires, except ATTI, were readministered at follow-ups.

Outcomes

Outcomes were based on measures of the associations between IT and baseline characteristics of the sample, the longitudinal trends of GD, body uneasiness, and general psychopathology; and IT as a moderator of the longitudinal trend of body uneasiness.

Results

At baseline, IT correlated with lower level of education, higher GD, and more severe body uneasiness. Longitudinal analyses showed significant improvements in GD, body uneasiness, and general psychopathology during GAHT. Moderation analysis confirmed that participants with more transphobic attitudes showed less improvement after GAHT with regard to body uneasiness (bTime*ATTI = −.002, P = .040). The Johnson-Neyman technique revealed that no significant improvement in body uneasiness was found for participants with ATTI scores lower than 71.14.

Clinical Implications

The presence of IT should be investigated in subjects with GD who require gender affirming treatments to provide specific interventions aimed at targeting this dimension.

Strengths and Limitations

Strengths of this study include the mixed cross-sectional and longitudinal design and the dimensional evaluation of the investigated constructs. Limitations include the small sample size and the limited follow-up. Furthermore, the effects of gender affirming surgery were not evaluated.

Conclusion

The association of IT with both baseline body uneasinessand the longitudinal course of this dimension highlighted the clinical significance of body uneasiness and the importance of making continuous efforts to improve education and information to fight societal stigmas.
Differential sensitivities of photosynthetic processes and carbon loss mechanisms govern N-induced variation in net carbon assimilation rate for field-grown cotton
Authors: Parkash Ved , Snider John L , Sintim Henry Y , Hand Lavesta C , Virk Gurpreet , Pokhrel Amrit
Published: January 2023

Nitrogen (N) deficiency limits the net carbon assimilation rate (AN), but the relative N sensitivities of photosynthetic component processes and carbon loss mechanisms remain relatively unexplored for field-grown cotton. Therefore, the objective of the current study was to define the relative sensitivity of individual physiological processes driving N deficiency-induced declines in AN for field-grown cotton. Among the potential diffusional limitations evaluated, mesophyll conductance was the only parameter substantially reduced by N deficiency, but this did not affect CO2 availability in the chloroplast. A number of metabolic processes were negatively impacted by N deficiency, and these effects were more pronounced at lower leaf positions in the cotton canopy. Ribulose bisphosphate (RuBP) regeneration and carboxylation, AN, and gross photosynthesis were the most sensitive metabolic processes to N deficiency, whereas photosynthetic electron transport processes, electron flux to photorespiration, and dark respiration exhibited intermediate sensitivity to N deficiency. Among thylakoid-specific processes, the quantum yield of PSI end electron acceptor reduction was the most sensitive process to N deficiency. It was concluded that AN is primarily limited by Rubisco carboxylation and RuBP regeneration under N deficiency in field-grown cotton, and the differential N sensitivities of the photosynthetic process and carbon loss mechanisms contributed significantly to photosynthetic declines.
A novel mutant allele of AtCNGC15 reveals a dual function of nuclear calcium release in the root meristem
Authors: Tipper Emily , Leitão Nuno , Dangeville Pierre , Lawson David M , Charpentier Myriam
Published: January 2023

Calcium release to the nucleoplasm of root meristem cells was demonstrated to modulate root development. The calcium channel encoded by cyclic nucleotide-gated channel (CNGC) 15 localizes at the nuclear envelope in young Arabidopsis seedlings. In contrast, at later stages of root growth, overexpression analysis showed that AtCNGC15 can relocalize to the plasma membrane to mediate primary nitrate-induced gene expression. This raises the question as to whether nuclear localized AtCNGC15 is required for root apical meristem development in young Arabidopsis seedlings, and whether nitrate signalling occurs independently of nuclear localized AtCNGC15 at this developmental stage. In this study, we characterize a novel mutant allele of AtCNGC15 and demonstrate that the mutation of a highly conserved aspartic acid in the C-linker domain is sufficient to impair the gating of AtCNCG15. We demonstrate that AtCNGC15 mediates the nuclear calcium release that modulates root apical meristem development and nitrate-induced LBD39 expression. We also show that, in the presence of nitrate, the relocalization of AtCNGC15 at the plasma membrane occurs specifically in the columella cells. Our results further suggest that the induction of LBD37, LBD38, and LBD39 in the presence of nitrate is modulated by different inputs of cytoplasmic or nuclear calcium release.
Relevant epistemic logic with public announcements and common knowledge
Authors: PunČochář Vít , Sedlár Igor , Tedder Andrew
Published: January 2023

We study a version of public announcement logic with common knowledge based on the relevant logic $\textsf {R}$. Public announcements, as represented in our framework, are not necessarily truthful and accepted by all agents, nor is it assumed that beliefs are preserved under announcements. We establish a completeness result with respect to a relational semantics, and we show that an alternative semantics based on information states is dual to the relational one. We add a question-forming inquisitive disjunction operator to the language and prove a completeness result with respect to the information semantics.
Logical Realism and the Riddle of Redundancy
Authors: Monroy Pérez Óscar Antonio
Published: January 2023

According to an influential view, when it comes to representing reality, some words are better suited for the job than others. This is elitism. There is reason to believe that the set of the best, or elite, words should not be redundant or arbitrary. However, we are often forced to choose between these two theoretical vices, especially in cases involving theories that seem to be mere notational variants. This is the riddle of redundancy: both redundancy and arbitrariness are vicious, but there are cases in which one must be picked. Logical realists admit that there are some logical constants among the elite words. This leads to awkward questions, such as which among conjunction and disjunction is elite. In this paper, I show how the riddle of redundancy arises for logical realists, and offer a solution. This approach requires us to change how we represent negation. Instead of using some particular symbol, we represent negation by flipping formulae over the horizontal axis.
Neo-Logicism and Gödelian Incompleteness
Authors: Pregel Fabian
Published: January 2023

There is a long-standing gap in the literature as to whether Gödelian incompleteness constitutes a challenge for Neo-Logicism, and if so how serious it is. In this paper, I articulate and address the challenge in detail. The Neo-Logicist project is to demonstrate the analyticity of arithmetic by deriving all its truths from logical principles and suitable definitions. The specific concern raised by Gödel’s first incompleteness theorem is that no single sound system of logic syntactically implies all arithmetical truths. I set out some responses that initially seem appealing and explain why they are not compelling. The upshot is that Neo-Logicism either offers an epistemic route only to some truths of arithmetic; or that it has to move from a syntactic to a semantic notion of logical consequence, which risks undermining its epistemic goals. I conclude by considering Crispin Wright’s recent attempt to address Gödelian incompleteness, which I argue is not satisfactory.
Genomic description of human clinicalAspergillus fumigatusisolates, California, 2020
Authors: Misas Elizabeth , Deng John Z , Gold Jeremy A W , Gade Lalitha , Nunnally Natalie S , Georgacopoulos Ourania , Bentz Meghan , Berkow Elizabeth L , Litvintseva Anastasia P , Chiller Tom M , Klausner Jeffrey D , Chow Nancy A
Published: January 2023

Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole genome sequencing of 24 A. fumigatus isolates collected from 18 patients in U.S. healthcare facilities in California. Single-nucleotide polymorphism (SNP) differences between patient isolates ranged from 187 to 70 829 SNPs. For five patients with multiple isolates, we calculated the within-host diversities. Three patients had a within-host diversity that ranged from 4 to 10 SNPs and two patients ranged from 2 to 16 977 SNPs. Findings revealed highly diverse A. fumigatus strains among patients and two patterns of diversity for isolates that come from the same patient, low and extremely high diversity.
Spiral structure and massive star formation in the hub-filament-system G326.27-0.49
Authors: Mookerjea Bhaswati , Veena V S , Güsten Rolf , Wyrowski F , Lasrado Akhil
Published: January 2023

Hub-filament systems (HFSs) are potential sites of formation of star clusters and high mass stars. To understand the HFSs and to provide observational constraints on current theories that attempt to explain star formation globally, we report a study of the region associated with G326.27-0.49 using infrared data of dust continuum and newly obtained observations on molecular tracers using the APEX (Atacama Pathfinder EXperiment) telescope. We use the spectroscopic observations to identify velocity-coherent structures (filaments and clumps) and study their properties at a resolution of 0.4 pc. The region contains two main velocity components: first component shows four filaments between −63 and −55 km s−1 forming a spiral structure converging in a hub, the second filamentary component at ∼−72 km s−1 harbours a massive young stellar object (YSO) and possibly interacts with the hub. The clumps harbouring the three main YSOs in the region are massive (187–535 M⊙), have luminosities consistent with B-type stars, have central densities of ∼106 cm−3, and drive large outflows. Majority of the velocity-coherent clumps in the region shows virial parameters between 2 and 7, which considering the detection of protostars implies collapse to be gradual. We conclude that the region consists of a network of filaments through which mass accretes (∼10−4 M⊙ yr−1) onto the hub. The hub and some of the ends of filaments appear to be undergoing collapse to form new stars. This study identifies a target region for future high-resolution studies that would probe the link between the core and filament evolution.
The complex multiscale structure in simulated and observed emission maps of the proto-cluster cloud G0.253+0.016 (‘the Brick’)
Authors: Petkova Maya A , Kruijssen J M Diederik , Kluge A Louise , Glover Simon C O , Walker Daniel L , Longmore Steven N , Henshaw Jonathan D , Reissl Stefan , Dale James E
Published: January 2023

The Central Molecular Zone (the central ∼500 pc of the Milky Way) hosts molecular clouds in an extreme environment of strong shear, high gas pressure and density, and complex chemistry. G0.253+0.016, also known as ‘the Brick’, is the densest, most compact, and quiescent of these clouds. High-resolution observations with the Atacama Large Millimetre/submillimetre Array (ALMA) have revealed its complex, hierarchical structure. In this paper we compare the properties of recent hydrodynamical simulations of the Brick to those of the ALMA observations. To facilitate the comparison, we post-process the simulations and create synthetic ALMA maps of molecular line emission from eight molecules. We correlate the line emission maps to each other and to the mass column density and find that HNCO is the best mass tracer of the eight emission lines within the simulations. Additionally, we characterize the spatial structure of the observed and simulated cloud using the density probability distribution function (PDF), spatial power spectrum, fractal dimension, and moments of inertia. While we find good agreement between the observed and simulated data in terms of power spectra and fractal dimensions, there are key differences in the density PDFs and moments of inertia, which we attribute to the omission of magnetic fields in the simulations. This demonstrates that the presence of the Galactic potential can reproduce many cloud properties, but additional physical processes are needed to fully explain the gas structure.
Centrifugal barriers in magnetospheric accretion
Authors: Lyutikov Maxim
Published: January 2023

We reconsider the dynamics of accretion flows onto magnetized central star. For dipolar magnetically aligned case, the centrifugal barrier is at Rcb = (2/3)1/3Rc = 0.87Rc, where Rc = (GM/Ω2)1/3 is the corotation radius. For oblique dipole direct accretion from the corotation radius Rc is possible only for magnetic obliquity satisfying $\tan \theta _\mu \ge 1/(2 \sqrt{3})$ (θμ ≥ 16.1°). The accretion proceeds in a form of funnel flows – along two streams centred on the μ–Ω plane, with azimuthal opening angle $\cos (\Delta \phi) = { \cot ^ 2 {\theta _\mu } }/{12}$. For the magnetosphere distorted by the diamagnetic disc, the centrifugal barrier can be at as small radius as Rcb = 0.719Rc for the fully confined dipole, extending out to Rcb ∼ Rc for the magnetically balanced case. Type-II X-ray bursts in accreting neutron stars may be mediated by the centrifugal barrier; this requires nearly aligned configuration. Centrifugally barriered material trapped in the magnetosphere may lead to periodic obscuration (‘dips’) in the light curve of the host star, e.g. as observed in accreting young stellar objects and X-ray binaries.
Identifying Zeeman pairs of hydroxyl masers in NGC 6334I-MM3 via velocity drift
Authors: MacLeod G C , Smits D P , Hunter T R , Brogan C , Chibueze J O , van den Heever S P
Published: January 2023

A new tool to identify possible Zeeman pairs is presented here: the right circularly polarized (RCP) and left circularly polarized (LCP) components of a pair with velocity drift at the same rate. Long-term monitoring of hydroxyl transitions towards NGC 6334I-MM3 has resulted in the identification of three possible Zeeman pairs, one each at the 1.667, 6.030, and 6.035 GHz transitions, where the rate of drift of the RCP feature equals that of the LCP component. Historical observations suggest that their drift has been occurring over 40 yr. A fourth pair in the 1.720 GHz OH transition may indicate magnetic field variation over 50 yr.
The quasi-adiabatic relaxation of haloes in the IllustrisTNG and EAGLE cosmological simulations
Authors: Velmani Premvijay , Paranjape Aseem
Published: January 2023

The dark matter content of a gravitationally bound halo is known to be affected by the galaxy and gas it hosts. We characterize this response for haloes spanning over four orders of magnitude in mass in the hydrodynamical simulation suites IllustrisTNG and EAGLE. We present simple fitting functions in the spherically averaged quasi-adiabatic relaxation framework that accurately capture the dark matter response over the full range of halo mass and halo-centric distance we explore. We show that commonly employed schemes, which consider the relative change in radius rf/ri − 1 of a spherical dark matter shell to be a function of only the relative change in its mass Mi/Mf − 1, do not accurately describe the measured response of most haloes in IllustrisTNG and EAGLE. Rather, rf/ri additionally explicitly depends upon halo-centric distance rf/Rvir for haloes with virial radius Rvir, being very similar between IllustrisTNG and EAGLE and across halo mass. We also account for a previously unmodelled effect, likely driven by feedback-related outflows, in which shells having rf/ri ≃ 1 (i.e. no relaxation) have Mi/Mf significantly different from unity. Our results are immediately applicable to a number of semi-analytical tools for modelling galactic and large-scale structure. We also study the dependence of this response on several halo and galaxy properties beyond total mass, finding that it is primarily related to halo concentration and star formation rate. We discuss possible extensions of these results to build a deeper physical understanding of the small-scale connection between dark matter and baryons.
The extent of intergalactic metal enrichment from galactic winds during the Cosmic Dawn
Authors: Yamaguchi Natsuko , Furlanetto Steven R , Trapp A C
Published: January 2023

One of the key processes driving galaxy evolution during the Cosmic Dawn is supernova feedback. This likely helps regulate star formation inside of galaxies, but it can also drive winds that influence the large-scale intergalactic medium. Here, we present a simple semi-analytic model of supernova-driven galactic winds and explore the contributions of different phases of galaxy evolution to cosmic metal enrichment in the high-redshift (z ≳ 6) Universe. We show that models calibrated to the observed galaxy luminosity function at z ∼ 6–8 have filling factors $\sim 1{{\%}}$ at z ∼ 6 and $\sim 0.1{{\%}}$ at z ∼ 12, with different star formation prescriptions providing about an order of magnitude uncertainty. Despite the small fraction of space filled by winds, these scenarios predict an upper limit to the abundance of metal-line absorbers in quasar spectra at $z \gtrsim 5$ which is comfortably above that currently observed. We also consider enrichment through winds driven by Pop III star formation in minihalos. We find that these can dominate the total filling factor at $z \gtrsim 10$ and even compete with winds from normal galaxies at z ∼ 6, at least in terms of the total enriched volume. But these regions have much lower overall metallicities, because each one is generated by a small burst of star formation. Finally, we show that Compton cooling of these supernova-driven winds at $z \gtrsim 6$ has only a small effect on the cosmic microwave background.
SALT2 versus SALT3: updated model surfaces and their impacts on type Ia supernova cosmology
Authors: Taylor G , Jones D O , Popovic B , Vincenzi M , Kessler R , Scolnic D , Dai M , Kenworthy W D , Pierel J D R
Published: January 2023

For the past decade, SALT2 has been the most common model used to fit Type Ia supernova (SN Ia) light curves for dark energy analyses. Recently, the SALT3 model was released, which upgraded a number of model features but has not yet been used for measurements of dark energy. Here, we evaluate the impact of switching from SALT2 to SALT3 for a SN cosmology analysis. We train SALT2 and SALT3 on an identical training sample of 1083 well-calibrated Type Ia supernovae, ensuring that any differences found come from the underlying model framework. We publicly release the results of this training (the SALT ‘surfaces’). We then run a cosmology analysis on the public Dark Energy Survey 3-Yr Supernova data sample (DES-SN3YR), and on realistic simulations of those data. We provide the first estimate of the SN + CMB systematic uncertainty arising from the choice of SALT model framework (i.e. SALT2 versus SALT3), Δw  = + 0.001 ± 0.005 – a negligible effect at the current level of dark energy analyses. We also find that the updated surfaces are less sensitive to photometric calibration uncertainties than previous SALT2 surfaces, with the average spectral energy density dispersion reduced by a factor of two over optical wavelengths. This offers an opportunity to reduce the contribution of calibration errors to SN cosmology uncertainty budgets.
Spatial and orbital planes of the Milky Way satellites: unusual but consistent with ΛCDM
Authors: Pham Khanh , Kravtsov Andrey , Manwadkar Viraj
Published: January 2023

We examine the spatial distribution and orbital pole correlations of satellites in a suite of zoom-in high-resolution dissipationless simulations of Milky Way (MW)-sized haloes. We use the measured distribution to estimate the incidence of satellite configurations as flattened and as correlated in their orbital pole distribution as the satellite system of the MW. We confirm that this incidence is sensitive to the radial distribution of subhaloes and thereby to the processes that affect it, such as artificial disruption due to numerical effects and disruption due to the central disc. Controlling for the resolution effects and bracketing the effects of the disc, we find that the MW satellite system is somewhat unusual (at the ≈2–3σ level) but is statistically consistent with the Lambda cold dark matter model, in general agreement with results and conclusions of other recent studies.
Reactive arthritis after Gam-COVID-Vac vaccination: A case report
Authors: Shokraee Kamyar , Rezaei Somaye Sadat , Shahriarian Shahriar , Masoumi Maryam , Parsaei Amirhossein , Amini Behnam
Published: January 2023

Although the safety and efficacy of vaccinations have been evaluated through clinical trials, medical experts and authorities are very interested in the reporting and investigation of adverse events following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunisation in the general public. This article reports about a 41-year-old man without a history of underlying diseases, complaining of continuous morning stiffness and acute discomfort in his left elbow joint, 20 days after taking the first dosage of Sputnik V. The case was extensively studied, and a possible diagnosis of reactive arthritis was made.
A severe cerebral infarction associated with giant cell arteritis, which developed during tocilizumab therapy and was successfully treated with intravenous cyclophosphamide
Authors: Suzuki Koji , Akiyama Mitsuhiro , Ishigaki Sho , Kondo Yasushi , Saito Shuntaro , Kikuchi Jun , Hanaoka Hironari , Kaneko Yuko
Published: January 2023

Giant cell arteritis (GCA) is a large vessel vasculitis that primarily involves aorta and its major branches. Cerebral infarction is a serious complication that can occur secondary to GCA in up to 3% of patients with a mortality rate of over 50%. Due to the rarity of this severe complication, no therapeutic strategies are currently available. Furthermore, despite the recent progress in molecular-targeted therapy for GCA, it remains unknown whether tocilizumab is effective for severe ischemic complications such as cerebral infarction. The accumulation of individual cases in which this fatal complication could be treated is apparently required to build a better management of the disease. We present our case of GCA that developed severe cerebral infarction during high-dose glucocorticoid and tocilizumab therapy, and its symptoms and image findings were improved by switching to intravenous cyclophosphamide. Our case suggests that an intensive immunosuppressive therapy, including cyclophosphamide, may be necessary to stabilise this fatal complication of GCA.