bluuebunny/crossref_metadata_2025 huggingface dataset:
Gender bias in urology: The role of gender in selecting urology as a medical specialty
Authors: Alnazari Mansour , Aljohani Abdullah K. , Rajih Emad S. , Bakhsh Abdulaziz , Alghamdi Ghadi S. , Sebaa Faris S. , Alraddadi Ali A. , Moalwi Adel
Published: January 2025

Background:

Gender inequality has been prevalent in the history of medicine, specifically within surgical specialties. Although there have been advances, urology has remained overwhelmingly male-dominant, with slow growth in female recruitment.

Objectives:

The study aimed to assess whether the gender influences selection of medical specialty, especially gender bias in urology.

Materials and Methods:

A cross-sectional study was conducted among undergraduate medical students in Saudi Arabian medical schools to explore the influence of gender on urology specialty selection. Data were collected from November 2023 to June 2024 using a structured questionnaire administered electronically. A pilot study was conducted to evaluate the questionnaire’s reliability and clarity. Data were analyzed using descriptive and inferential statistics. The questionnaire demonstrated acceptable reliability.

Results:

The total study participants were 602 medical students. The dataset reveals a balanced gender representation, with males constituting 55.6% and females 44.4%. A substantial majority, 94.5%, expressed a definitive willingness to pursue further residency training following graduation, indicating a robust commitment to advancing their medical careers. However, while evaluating interest in urology, the statistics revealed a potential disparity, with only 43.2% affirmatively considering urology as a specialty, contrasted against 56.8% who would not. The study shows that the participants’ considering urology as a specialty has a statistically significant relation to gender (P = 0.0001) as 72.3% of those who would consider the specialty were males compared to only 27.7% for females. The data also show a concerning trend where 21.8% of those uninterested in urology reported insufficient exposure during medical school as a deterrent, while others found the specialty to be embarrassing or simply uninteresting, accounting for 70.8% of the negative responses.

Conclusion:

This study reveals a significant gender disparity in urology specialty selection among medical students. While the majority of students intend to pursue residency training, male students are significantly more likely to consider urology as a specialty compared to female students. Factors such as limited exposure and negative perceptions contribute to the underrepresentation of women in urology. Addressing these issues is crucial to achieving gender equality within the field.
Nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 inflammasome: From action mechanism to therapeutic target in clinical trials
Authors: Zhang Chun-Ye , Liu Shuai , Sui Yu-Xiang , Yang Ming
Published: January 2025

The nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a critical modulator in inflammatory disease. Activation and mutation of NLRP3 can cause severe inflammation in diseases such as chronic infantile neurologic cutaneous and articular syndrome, Muckle-Wells syndrome, and familial cold autoinflammatory syndrome 1. To date, a great effort has been made to decode the underlying mechanisms of NLRP3 activation. The priming and activation of NLRP3 drive the maturation and release of active interleukin (IL)-18 and IL-1β to cause inflammation and pyroptosis, which can significantly trigger many diseases including inflammatory diseases, immune disorders, metabolic diseases, and neurodegenerative diseases. The investigation of NLRP3 as a therapeutic target for disease treatment is a hot topic in both preclinical studies and clinical trials. Developing potent NLRP3 inhibitors and downstream IL-1 inhibitors attracts wide-spectrum attention in both research and pharmaceutical fields. In this minireview, we first updated the molecular mechanisms involved in NLRP3 inflammasome activation and the associated downstream signaling pathways. We then reviewed the molecular and cellular pathways of NLRP3 in many diseases, including obesity, diabetes, and other metabolic diseases. In addition, we briefly reviewed the roles of NLRP3 in cancer growth and relative immune checkpoint therapy. Finally, clinical trials with treatments targeting NLRP3 and its downstream signaling pathways were summarized.
Identifying adipocyte-derived exosomal miRNAs as potential novel prognostic markers for radiotherapy of esophageal squamous cell carcinoma
Authors: Ge Yang-Yang , Xia Xiao-Chun , Wu An-Qing , Ma Chen-Ying , Yu Ling-Hui , Zhou Ju-Ying
Published: January 2025

BACKGROUND

Radiation resistance limits radiotherapy efficacy in esophageal squamous cell carcinoma (ESCC). The tumor microenvironment, particularly adipocytes, plays a role in promoting cancer progression. Extracellular vesicles and microRNAs (miRNAs) regulate gene expression and hold prognostic potential for esophageal carcinoma. Elucidating radioresistance mechanisms and identifying radiosensitization targets can help enhance radiotherapy efficacy for esophageal cancer.

AIM

To investigate the potential role of miRNAs derived from adipocyte exosomes as prognostic markers for radiotherapy efficacy in ESCC.

METHODS

Free adipocytes were isolated from human thoracic adipose tissue. A co-culture model of adipocytes and ESCC cells was established to observe colony formation and cell survival post-irradiation. ESCC cell apoptosis was assessed by flow cytometry. Western Blot and immunofluorescence assays were performed to evaluate DNA damage in ESCC cells post-irradiation. Adipocyte-derived exosomes were isolated by ultracentrifugation and identified by electron microscopy. A similar set of experiments was performed on ESCC cells to analyze cell survival, apoptosis, and DNA damage post-radiation exposure. Exosomes from adipose tissue and serum exosomes from ESCC patients pre- and post-radiotherapy were subjected to high-throughput miRNA-sequencing and validated using real-time quantitative polymerase chain reaction. The correlation between potential target miRNAs and the short-term prognosis of radiotherapy in ESCC was evaluated by receiver operating characteristic curve analysis.

RESULTS

Co-culturing adipocytes with ESCC cells enhanced radioresistance, as evidenced by increased colony formation. Adipocyte co-culture reduced ESCC cell apoptosis and DNA damage post-radiation. Adipocyte-derived exosomes similarly conferred radioresistance in ESCC cells, decreasing apoptosis and DNA damage post-irradiation. High-throughput miRNA-sequencing identified miR-660-5p in serum and adipose tissue exosomes. Patients with high expression of serum exosome miR-660-5p showed poor prognosis after radiotherapy.

CONCLUSION

Adipocyte-derived exosomal miR-660-5p is a potential biomarker for evaluating radiotherapy efficacy in ESCC.
Efficacy of sorafenib combined with transarterial chemoembolization in the treatment of advanced hepatocellular carcinoma: A meta-analysis
Authors: Xu Mei , Zhou Si-Rui , Li Ya-Ling , Zhang Chen-Hao , Liao Da-Zhong , Wang Xiao-Li
Published: January 2025

BACKGROUND

The combination of sorafenib with transarterial chemoembolization (TACE) is being investigated for its potential to improve outcomes in advanced hepatocellular carcinoma (HCC).

AIM

To evaluate the efficacy of this combined treatment strategy in enhancing overall survival (OS) and progression-free survival (PFS) compared to monotherapies.

METHODS

A systematic review was conducted following the PRISMA guidelines. A comprehensive search was performed across PubMed, EMBASE, Web of Science, and the Cochrane Library up to May 8, 2024. Studies were included if they compared sorafenib plus TACE to sorafenib alone or TACE alone in adults with advanced HCC. Primary outcomes were OS, PFS, response rates, and safety profiles. Data extraction and quality assessment were independently performed by two reviewers. Heterogeneity was assessed using the I² statistic, and a random-effects model was applied for pooling data. Sensitivity analysis and publication bias assessment were also conducted.

RESULTS

A total of twelve studies involving 1174 patients met the inclusion criteria. Significant heterogeneity was observed for both OS (I² = 72.6%, P < 0.001) and PFS (I² = 83.7%, P < 0.001). The combined treatment of sorafenib with TACE significantly improved OS [hazard ratio (HR) = 0.60, 95% confidence interval (CI): 0.44-0.76] and PFS (HR = 0.54, 95%CI: 0.38-0.69). Sensitivity analysis confirmed the robustness of these findings. Funnel plots and Egger's test indicated no significant publication bias.

CONCLUSION

Sorafenib combined with TACE significantly enhances both OS and PFS in patients with advanced HCC compared to monotherapy. This combination therapy represents a promising approach to improving clinical outcomes in advanced liver cancer.
Malignant perivascular epithelioid cell tumor of the colorectum: Clinicopathological characterization, diagnosis and treatment process of 7 cases
Authors: Ma Ming-Fei , Chi Zhen-Yu , Zhao Li-Juan , Zhai Wei , Zhong Wen , Wang Song
Published: January 2025

BACKGROUND

Perivascular epithelioid cell tumor (PEComa) of the colorectum is exceedingly rare, with only a few published reports. It presents with a wide spectrum of biological behavior, ranging from benign to malignant. The prognosis for malignant PEComa is poor and there is little consensus on its treatment.

AIM

To fully characterize PEComa and standardize its diagnosis and treatment.

METHODS

Patients with colorectal malignant PEComa were identified from the First Affiliated Hospital, Zhejiang University School of Medicine and People's Hospital of Anji. Cases with controversial pathology and cases lost to follow-up were excluded, leaving seven remaining cases that formed the basis of the study. We collected relevant clinicopathological, therapeutic and followup details. Disease stage and progression were assessed by contrast-enhanced computed tomography at baseline and at 3-month intervals.

RESULTS

The mean age was 43 years, with a range of 5 years to 73 years. The average body mass index was 21.8 ± 3.0 kg/m2, and 71.4% of cases occurred in the colon. The main symptoms of colorectal PEComas were abdominal mass and hematochezia. The most common microscopic finding of malignant behavior was infiltrative growth. Immunohistochemical analysis found that 6/7 cases were positive for HMB45, 5/7 were positive for melan-A, and 3/5 were positive for MiTF. The watch-and-wait approach to treatment was a risky option. Radical resection was preferable to systemic treatment. The median progression-free survival exceeded 38 months, longer than previously reported.

CONCLUSION

Radical or extended resection is the key to prolonged survival of malignant PEComa. More meaningful studies are urgently needed to establish the standardized diagnosis and treatment.
Vintage Hunters: Creating Vintage in the Czech Republic
Authors: Borisova Varvara
Published: January 2025

The paper examines the creation of value in Czech vintage stores, focusing on how sellers transform pre-owned garments into desirable vintage items. Based on twelve semi-structured interviews and observations at seller-organized events, I explore the strategies and practices sellers employ to produce and enhance the value of second-hand clothing. The research highlights that they draw on their expertise, knowledge, and skills to justify the value of garments and reintegrate them into the market exchange. The findings suggest that while sellers perceive value as intrinsic to the quality of the item, the process of “valuing” (Heuts & Mol, 2013) requires their active engagement. This paper aims to contribute to the growing scholarship on thrift and second-hand economies (Greeson, 2018; Brooks, 2019; Alexander & Sosna, 2022), highlighting the interplay between sustainability, nostalgia, and fashion.
CLINICAL STUDY OF HEMADRI RASA IN TAMAKA SHWASA – A UNIQUE FORMULATION
Authors: Puranik M Subrahmanya , Diggavi Madhava , Hegde Prajna
Published: January 2025

Ayurveda offers treatment for all disorders known to men. One of the ancient diseases that often troubles humankind is Tamaka Shwasa or Bronchial Asthma. Hemadri rasa is a formulation postulated by Rasendra Chinthamani
containing Shuddha Parada, Shuddha Gandhaka, Shuddha Tamra and Shuddha Manashila, with a unique preparation method. Inclusion Criteria - Symptoms of Shwasa Krichratha, Kasa, Kanta ghurghuratha, Asino Labhate
Soukhyam, and Ura Shula were considered. Objective criteria – ESR, AEC, DEC, FEV ratio and Chest X-ray.
Results - Shwasa Kruchratha – 100%, Kanta ghurghuratha – 82.2%, Kasa – 56.59%, Asino Labhate shoukhyam –
100%, Ura Shula – 100%, ESR – 40.47%, AEC – 60.93%, DEC – 53.57%, FEV ratio - 2.7%. Overall effect of
therapy – No improvement – 0%, Mild improvement – 07%, Moderate improvement – 03%, Marked improvement – 60%, Significant improvement – 30%.
THE COMPARATIVE CLINICAL STUDY OF GUDUCHYADI KWATH PRAKSHALAN AND VAGINAL PESSARY IN MANAGEMENT OF YONIKANDU WITH SPECIAL REFERENCE TO TRICHOMONAS VAGINITIS
Authors: Attarde Jyotsna , Lomte Pankaj
Published: January 2025

Yonikandu, i.e. pruritus vulva, is one of the very annoying and troublesome symptoms of women’s genital tract
infections Yogaratnakara has described the Guduchyadi kwatha prakshalana in Yonikandu tenderness etc. aims
and objective- To evaluate the effect of Guduchyadi kwath prakshalan and compare the results of Guduchyadi
kwath prakshalan & Clotrimazole vaginal pessary in management of Yonikandu. Methodology - Prospective
open randomised controlled study. In this study, 60 randomly selected Yonikandu patients were divided into two
equal groups in the trial group 30 patients treated with Guduchyadi kwath prakshalan and 30 patent treated with
Clotrimazole vaginal pessary for 7 days after cessation of menses. Statistical Analysis and Discussion- Statistical analysis and the result will be discussed in detail in the paper. Result- The results are encouraging. The therapy shows marked relief from all symptoms of Yonikandu Conclusion- guduchyadi kwath prakshalan is more significant than Clotrimazole vaginal pessary for reduction of Symptoms.
VAMANA KARMA IN SHALAKYA TANTRA
Authors: Sharma Vasudha , Sharma Abhishek
Published: January 2025

Vaman, an essential therapeutic procedure in Ayurveda, involves the induced vomiting of doshas, primarily targeting the Kapha and Pitta imbalances. This process is a key component of Panchakarma therapies, particularly
within the Shalakya Tantra branch of Ayurveda, which addresses diseases of the ear, nose, throat, and related sensory organs. This study aims to elucidate the mechanisms and therapeutic significance of Vamana in Shalakya
Tantra, focusing on its roles in detoxification of kapha and pitta dosha, restoration of dosha balance, management
of various Shalakya tantra disorders, enhancement of digestive health (Agni), and improvement of sensory functions. Vamana procedure encompasses three phases according to aacharyas (Charaka, sushruta and vagbhata):
Purva Karma (preparatory processes), Pradhan Karma (the main therapeutic action), and Paschat Karma (postprocedure care). Preparatory steps include Snehana (oleation), Swedana (fomentation), dietary adjustments, and
psychological readiness. The primary action involves administering herbal characteristic Ushna (hot), Tikshna
(sharp), Sukshma (subtle), Vyavayi (expansive), and Vikasi (flourishing) to help in mode of action to induce
vomiting, carefully monitoring the patient throughout the process to assess the characteristics of the vomitus Antiki, Vaigiki, Maniki, Langiki which provide insights into the Kapha and pitta dosha being expelled.
MULTIFACETED ACTIONS OF EKAVIMSHATIKA GUGGULU AN ANALYTICAL REVIEW
Authors: P Aishwarya , Pratap Arun , R Lekshmi , Chandran Aparna
Published: January 2025

According to ancient Ayurvedic scholars, a precise analysis of any medication is essential for achieving desirable
outcomes before it is prescribed to patients. Ayurvedic physicians have successfully practised numerous classical
formulations for treating various ailments; however, there is often a lack of data regarding their detailed mechanism
of action. One such classical multidrug formulation is Ekavimshatika Guggulu. Gutika Kalpana is the most considerable and most used form of Ayurvedic pharmaceutical formulations. It is a herbal formulation explained in Bhavaprakasha Kushtadikara. It consists of 21 ingredients. This review aims to elucidate the multiple modes of action
of Ekavimshatika Guggulu in various diseases by analysing the pharmacological properties of its ingredients. Analysis of the mode of action gives a deep insight into the usage of formulations with a better understanding.
A STUDY TO EXPLORE TWAK LAKSHANA TO ASSESS INTERNAL HEALTH
Authors: M.V Swathi. , D.N Likhita. , M.S Mahalakshmi.
Published: January 2025

Introduction: Ayurveda describes the body as an interplay of Dosha, Dhatu, and Mala, serving as a vital diagnostic surface. Twak, the site of Sparshanendriya1
, reflects the relationship between Shareera, Indriya, and Manas, offering insights into systemic health. This study explores Twak Lakshana in classical Ayurvedic texts to
evaluate its role in diagnosing internal diseases. Objectives: To assess Twak's role in evaluating internal health,
compile references from Samhita, analyse Twak Lakshana in healthy and diseased individuals, and compare findings. Methodology: Data were collected from Ayurvedic texts and a questionnaire assessing Twak characteristics.
Participants, pre-diagnosed patients and healthy individuals were selected based on defined criteria, and their
Twak Lakshana findings were analysed. Results: Skin manifestations were observed in 66% of patients with systemic diseases. These signs, linked to Rasa and Raktha Dhatu, varied with disease chronicity, Ahara Rasa, and
Rasa Dhatu Poshana, reflecting the status of Dosha, Dushya, and Mala. Conclusion: Twak provides valuable
diagnostic insights into systemic diseases but is influenced by factors such as Desha, Kala, Vaya, Bala, Dosha,
and Prakruthi. Its diagnostic reliability depends on these variables and the disease's chronicity.
EFFECTS OF UDUMBARA JAL, MASANUMASIKA KALP, GARBHAPALA RASA, VASANT KALPA IN THE MANAGEMENT OF OLIGOHYDRAMNIOS - A CASE REPORT
Authors: Renuka Khamankar , Ketan Jangale
Published: January 2025

Oligohydramnios frequently demands intensive foetal surveillance and proper antepartum and intrapartum care. Its incidence is 1:750. Oligohydramnios is associated with increased perinatal morbidity and mortality. Features include IUGR, PIH, Abortion, Prematurity, IUFD, Malpresentations, Foetal distress, and Low APGAR, which are very emerging and life-threatening conditions for both mother and foetus in which the production of amniotic fluid is reduced and require immediate treatment and care. In the modern medicine they have not any particular treatment instead of giving adequate rest which decreases dehydration, hydration – Oral/IV Hypotonic fluids (2 Lit/d) or directly infusion of fluids in amniotic cavity, serial USG – Monitor growth and AFI. All these complica-tions result in higher rates of obstetrician intervention like induction of labour and caesarean delivery, which in-crease maternal risks as well. In Ayurveda, oligohydramnios can be considered under Upavishtaka, Nagodara, which comes under Garbha vyapad. Here, Garbhakshaya, as stated by Acharya Sushruta, where Garbhaaspan-dana, i.e. Ksheena Spandana (low foetal moments) and anunatkukshitta (Less fundal height) mentioned which is mainly due to the reduced amniotic fluid. A case study of a 20-year-old patient, primigravida with 20 weeks ges-tation, presented in OPD with fundal height less than gestational age on abdominal examination and AFI 6 cm on ultrasonography is presented. She managed efficiently by administering her with Udumbara Jal, Masanu-masika Kalp, Garbhapala Ras, and Vasant Kalpa orally and eating a diet according to Ayurveda. AFI increased to 9.5 cm on the 24th week, 12.9 cm at 29 weeks & 15.5 cm at 36 weeks and fundal height was increased and corresponded to the gestational ages. Foetal weight also increased from 300 gms to 657 gms, 1339 gms, & 2821 gms, respectively. This very effective treatment modality increases the amniotic fluid and provides good nour-ishment for the foetus.
MANAGEMENT OF HEPATIC ENCEPHALOPATHY WITH AYURVEDA
- A CASE REPORT
Authors: Kalamkar Gayatri , Mulani Kabir
Published: January 2025

Ayurveda is an Indian system of medicine that has been practised for thousands of years—Ayurveda medicines
have been found to be effective in most chronic diseases like liver cirrhosis, hepatitis, and hepatic encephalopathy. A 58-year the male patient was admitted with complaints of irrelevant talk, abdominal distension, anorexia,
drowsy, partially obeying verbal commands, yellowish discolouration of sclera, and bipedal oedema. The patient
was managed with Ayurveda medicines.
Hepatic encephalopathy (HE), the neuropsychiatric presentation of liver disease, is associated with high morbidity
and mortality.
AYURVEDIC APPROACH IN THE MANAGEMENT OF STYE: A CASE REPORT
Authors: Kumar Shaw Santosh
Published: January 2025

Stye is an infection of the sebaceous glands of Zeis located at the base of the eyelashes or the apocrine glands of
Moll. Stye can be correlated to Anjananamika in Ayurveda. Signs and symptoms such as a boil with a red (Tamra
varna) appearance and burning and pricking sensations around the eyelid (Vartma pradesha) will be present. Additionally, the condition is marked by mild pain with a soft, swollen eyelid (Mridvimandaruja). The treatment in
Ayurveda involves various therapies like Swedana (hot compress), Nishpidana (applying pressure to drain pus),
Bhedana (incision), Pratisarana (rubbing medicaments on the eyelids) and Anjana (collyrium). The main objective of this study is to assess the efficacy of Bidalaka (local application) and Ashchyotana (eye drops) along with
oral medicines in treating the disease Anjananamika. A 26-year-old female patient presented at the Shalakya Tantra outpatient department of Jeevan Jyoti Ayurveda Medical College and Hospital, Aligarh, with complaints of
multiple swelling in the right eyelid for eight days, pain and redness. Upon examination, the right eyelid showed
oedema along the entire edge, with an abscess at the apanga desha (outer canthus). Based on these clinical signs
and symptoms, the patient was diagnosed with Anjananamika and treated with Kriyakalpas tailored to the roga
Bala-condition's severity. After a week of treatment, the symptoms entirely resolved, emphasising the effectiveness of the Ayurvedic approach in managing Anjananamika.
Environmental Impacts on Heritage Sites in Bangladesh: The Case of Ruplal House
Authors: Rasheed Sazzadur , Ibne Iqbal Mian Md Jawad
Published: January 2025

Ruplal House, located along the Buriganga River in Old Dhaka, is a significant architectural heritage site that reflects 19th-century colonial-era design. This study examines the environmental and socio-economic challenges threatening its preservation. Issues such as structural decay, illegal encroachments, and policy inadequacies are analyzed. Data from field surveys, stakeholder interviews, and secondary research inform recommendations for conservation strategies, emphasizing policy reform, community involvement, and adaptive reuse to protect its historical integrity and promote sustainable urban development.
PRINCIPLES OF ERROR-TAGGED LEARNER CORPUS CONSTRUCTION: INSIGHTS FROM SERBIAN LEARNERS OF PERSIAN
Authors:   University of Belgrade, Faculty of Philology, Safari Saeed
Published: January 2025

Тhe error-tagged learner corpus is a significant and specialized type of learner corpora that can methodically identify learners’ errors and generate various reports and analyses to investigate the challenges and difficulties in language learning. This corpus is developed by collecting learners’ written or spoken productions and annotating the errors using an error-tag system. The reports and analyses of the corpus can be cate- gorized based on variables such as first-language background, proficiency levels, age, gender, and more. The error-tagged learner corpus can be used for theoretical and practical research analysis in linguistics, second language acquisition (SLA), and foreign language teaching (FLT). At the theoretical level, corpus reports can be used to study interlanguage and learning development. At the practical level, such analysis can help to develop need-based and specific learning materials and to select effective learning strategies and teaching methods. This paper aims to introduce and explain the process of developing an error-tagged learner corpus, structured in two sections. The first part of the paper outlines the basic principles and methodology for designing and constructing an error- tagged learner corpus. Specifically, it introduces the structural frame- work by listing design criteria and tools for constructing such a corpus. The second part presents a detailed case study of the Persian error-tagged learner corpus developed by collecting authentic written texts from Serbian Farsi learners. Based on the corpus analysis, Serbs’ most frequent errors and difficulties in learning Persian were identified, mainly related to word order, orthography, and some specific syntactic structures.
ŽENSKA MUŠKOST: FILON ALEKSANDRIJSKI IZMEĐU MIZOGINIJE I FEMINIZMA
Authors:   University of Belgrade, Faculty of Orthodox Theology, Serbia, Đakovac Aleksandar S.
Published: January 2025

Philo of Alexandria reflects the prevalent gender stereotypes of his era, associating femi-
ninity with weakness and passivity, and masculinity with strength and activity. However, his

symbolic interpretations create a space for a more nuanced understanding of these concepts.
This approach delinks these traits from specific men and women. Consequently, women can
embody masculine traits and vice versa. While Philo reinforces these traditional associations,
his emphasis on symbolic roles offers a potential pathway towards gender equality within Judeo-Christian cultural and intellectual heritage. Although this path is long and winding,
Philo’s work represents an early step.
THE PILGRIM’S PROGRESS: OD RUKOPISA IZ ZATVORSKE ĆELIJE XVII VEKA DO SAVREMENIH MULTIMEDIJA
Authors:   Belgrade Business and Arts Academy of Applied Studies, Serbia, Mirković Dragica D.
Published: January 2025

Trying to answer the question of how the book of an uneducated thinker was a bestseller
that sold more than 100,000 copies during Banyan’s lifetime, with around 1,300 editions by
1938, received the status of a forerunner of the novel in the English literature, was translated
into about 216 world languages, and its author was called “the Spenser of the people” and “the
Shakespeare of the Puritans”, this paper investigates the impact of John Bunyan’s (1628-1688)
multi-layered fiction on different generations expecting to reveal the potential of multiple
readings of the allegory The Pilgrim’s Progress (1678, 1684) to the modern reader.
THE CONTRIBUTION OF EUROPOL, FRONTEX, EPPO AND EUROJUST IN THE AREA OF FREEDOM, SECURITY AND JUSTICE
Authors: Korontzis Tryfon
Published: January 2025

The aim of this paper is the critical presentation of the European Union (EU) legal texts and especially of the main European Organizations that are activated in the Area of Freedom, Security and Justice (AFSJ) [Schengen Area] and specifically in dealing with organized crime and terrorism in the EU [Europol, Eurojust, Frontex as well as the recent institution of the European Public Prosecutor Office (EPPO)] and in particular the powers and duties assigned to them and the efficiency related to their action in the area in question. Research has been carried out in the areas of freedom, security and justice: general aspects, asylum policy, immigration policy, management of external borders, judicial cooperation in criminal cases, and police cooperation at the EU level by evaluating EU legal texts, scientific articles and literature and drawing on data from the EU specific Agencies.
 

 Article visualizations:
BUILDING A CHINA - AFRICA COMMUNITY WITH A SHARED FUTURE: PATHWAYS AND PRACTICE
Authors: Kitili Ike M.
Published: January 2025

Building a China-Africa Community with a Shared Future requires a nuanced understanding of its concept and the broader vision of a Community with a Shared Future for Mankind. By tracing historical and contemporary drivers, this exploration identifies five strategic pathways: fostering cultural exchange, promoting inclusive economic growth, strengthening collaboration in poverty reduction and public health, establishing a Peace and Security Forum, and advancing climate-focused environmental initiatives. Successfully navigating international complexities and Africa’s internal diversity demands enhanced dialogue and respect for African development autonomy. This endeavour holds transformative potential, rooted in political trust, economic partnership, and shared prosperity, to address global challenges.
 

 Article visualizations:
Comparison of the Laws Governing Online Loans in England and Indonesia
Authors: Nurhilmiyah  , Purba Hasim , Sitompul Zulkarnain , Azwar Tengku Keizerina Devi
Published: January 2025

Introduction: This study compares the laws governing online lending, or peer-to-peer lending, in the UK and Indonesia, two nations with distinct fintech market features. This paper examines the legal framework that oversees the online lending sector in both nations using a normative juridical and comparative approach, with a particular emphasis on consumer protection, risk management, and regulatory supervision.
 
Objective: According to the study's findings, Indonesia's fintech industry is governed by the Financial Services Authority, but the UK has more developed laws with the Financial Conduct Authority (FCA) as the only body in charge. in contrast to Indonesia, the UK has more stringent licensing procedures and higher minimum capital requirements.
 
Theoretical Framework: According to the study's findings, Indonesia's fintech industry is governed by the Financial Services Authority, but the UK has more developed laws with the Financial Conduct Authority (FCA) as the only body in charge. in contrast to Indonesia, the UK has more stringent licensing procedures and higher minimum capital requirements.
 
Method: This research uses a case approach to analyze existing problems. There are differences in legal regulations that cause problems. implementation of sanctions and supervision that cannot be implemented properly. These indications will be analyzed to find solutions to existing problems.
 
Results and Discussion: While Indonesia has just recently started to create comparable safeguards for investors, the UK mandates that online lending platforms have explicit backup plans and reserves to protect consumers.
 
Research Implications: There are still regulatory loopholes that need to be filled, especially in the areas of data protection, transparency, and dispute resolution procedures, despite Indonesia's notable legislative advancements in the online lending sector, according to this report.
 
Originality/Value: Taking into account the local market's features and the degree of financial knowledge of the Indonesian populace, this study suggests that Indonesia implement some of the best practices from the UK regulatory system.
The Mediating Role of Strategic Intelligence in the Relationship Between Administrative Creativity and Decision-Making Styles in Jordanian Universities
Authors: Shaqra Rawan Khader Abu , Alsadi Mohammad
Published: January 2025

Objective: The study aimed to identify the mediating role of strategic intelligence in the relationship between administrative creativity and decision-making styles in Jordanian universities.
 
Method: To achieve the study's goal, the predictive descriptive approach was used through the design of a research tool that included three main axes: strategic intelligence, administrative creativity, and decision-making styles. This tool was distributed to faculty members in Jordanian universities, with a total of 346 participants.
 
Results: The study results showed that the level of strategic intelligence among department heads was high. Additionally, it revealed that administrative creativity skills were also high.
 
Findings: The findings further indicated that department heads predominantly used rational decision-making styles compared to other styles. Moreover, strategic intelligence was found to mediate the relationship between administrative creativity and decision-making styles.
Electronic Fraud in the United Arab Emirates Legislations
Authors: Ibrahim Emad , Sharif Hanadi , Aboelazm Karem Sayed
Published: January 2025

Objective: Electronic Fraud is deemed one of the crimes that has been occurring frequently at work recently. The perpetrator uses fraudulent methods or takes false Names or incorrect data to deceive the victim through an electronic information system, pushing him to give up or hand over particular property or money.
 
Method: This paper relied mainly on a descriptive approach to examine Electronic Crimes and Fraud crimes in addition to studying some legal frameworks that regulate the Crime of Electronic Fraud.
 
Results and Discussion: Electronic fraud crimes have been uniquely featured in how they have been committed, and therefore, they have to be confronted with unique punitive and procedural texts. There is no doubt that Perp, detractors through the use of information technology, can quickly and conveniently reach an unlimited number of people and trick them into fraudulent traps without having any previous acquaintance with them. Besides, a Perpetrator can commit his crime from anywhere and defraud any person anywhere, as Modern Electronic means easily transcend any boundaries.
 
Research Implications: Inns give Perpetrators Courage and a Feeling of Safety while they commit their crimes; because their Personality and Location are entirely unknown, it is difficult to establish evidence for committing the Crof their Punishment.
 
Originality/Value: In the current Paper, we shall attempt to address Electronic Fraud Crime in terms of its Legal Structure and the prescribed Penalties by the Criminal Model as stipulated in Article No. 40 of Federal Law No. 34 of 2021, which regards the Combat of Rumors and electronic Crimes.
Early Childhood Care and Development from the Lens of Teachers: A Phenomenology
Authors:   Sto. Domingo Integrated School, A. Dasalla Ayrne Grace
Published: January 2025

Early childhood care and education emphasizes the child's social, emotional, cognitive, and physical needs for a strong foundation of learning and well-being. The study sought to determine the lived experiences of kindergarten teachers involved in early childhood care and development among their learners in the Schools Division of Ilocos Sur during the COVID-19 pandemic. A phenomenology was adopted with purposive sampling used to recruit participants with the following inclusive criteria: (1) kindergarten teachers, (2) involved in early childhood care and development, (3) male or female, (4) living in Ilocos Sur and (5) willing voluntarily to participate. The interview guide was used to gather and was validated by three teacher-experts. Significant findings revealed four major themes: (1) Psychological impact (stress and worries, lack of sleep, and fear for one’s life), (2) Personal growth (attending relevant webinars, attending online graduate school classes), (3) Support from Stakeholders (support from fellow teachers, support from local government, and support from community), and (4) Measures to achieve learning continuity (engage with parents, being technologically-competent, developing lessons for learners). Finally, the study recommends that the proposed early childhood care and development program may be considered by the community in partnership with the public school. Likewise, Kindergarten teachers may consider pursuing relevant training on enhancing learning among kindergarten pupils.
Physicochemical Properties of Liquid Organic Fertilizer from a Mixture of Fish Waste and Coffee Grounds
Authors:   Faculty of Agriculture, Wijaya Kusuma University, Surabaya, Indonesia, Sa’adah Tatuk Tojibatus , Haryanta Dwi ,   Faculty of Lecture Training and Education, Wijaya Kusuma University, Surabaya, Indonesia
Published: January 2025

Liquid fertilizer made from fish waste contains relatively high nutrients and effectively removes unpleasant odors during production. Coffee grounds are often used to remove unpleasant odors in rooms. This study aims to utilize coffee grounds to remove unpleasant odors in the production of liquid organic fertilizer from fish waste. The factorial experiment's first factor was the raw material for making liquid organic fertilizer (LOF), consisting of cow blood waste (P1) and fish waste (P2), while the second factor was the addition of coffee grounds at levels of 0% (K0), 10% (K1), 20% (K2), 30% (K3), and 40% (K4). The experiment was repeated three times using a completely randomized design (CRD). The results showed that adding coffee grounds at 20-30% of the total material could reduce the strong odor to a milder one, changing to a fermented smell at the end of the LOF production. Adding coffee grounds increased the macro and micronutrient content and reduced the C/N ratio in the resulting LOF. Adding 20-30% coffee grounds from the total raw materials is a solution to the problem of producing LOF from fish waste that remove unpleasant odors, while also utilizing coffee grounds that is usually discarded and can pollute the environment.
Factors Affecting MSMEs Using Shopee Food
Authors:   Universitas Muhammadiyah Purwokerto., Fauziridwan Meydy , Amir Biky Muhammad ,   Universitas Muhammadiyah Purwokerto., Risky Husen Muhammad Arjuna ,   Universitas Muhammadiyah Purwokerto., Ainunnisa Nadhira Safa ,   Universitas Muhammadiyah Purwokerto.
Published: January 2025

Recently, many new skincare products have been circulating in Indonesia. This is because of the availability of opportunities to gain market share in the skincare product business sector in Indonesia. The purpose of this study is to determine the influence of the dimensions of Advertise, Price and Product Quality on the Purchasing Decision of MS Glow products. This study is a quantitative research and the respondents in this study are 111 respondents. In this study, the sample was taken by nonprobability sampling, namely by accidental sampling technique. Based on data analysis, it shows that: (1) Advertise has a positive and significant effect on Purchase Decision, (2) Price has a positive and significant effect on Purchase Decision, (3) Product Quality has a positive and significant effect on Purchasing Decision.
Exploring the Potential Assessment of Geo-heritage Sites in Hyderabad: A Case Study
Authors:   Part time lecturer, Department of Geography, Osmania University, Hyderabad., Sudarshan Dr. K. , Srinagesh Prof. B. ,   Professor, Department of Geography, Osmania University, Hyderabad.
Published: January 2025

Geo-sites are places in nature that are more obviously noticeable. Sites classified as geoheritage are those that are more vulnerable to the history of a particular region or place. Geo-heritage sites combine geological, historical, cultural, and educational elements. To ensure that a region or culture survives, these important sites need to be recognized and preserved for next generations. Telangana has been controlled by several dynasties, and the region is home to several geo-heritage monuments, including Golkonda Fort and others in and around Hyderabad, which are encircled by ancient and geological structures. Each of these cultural sites, which are dispersed around Hyderabad, has a unique historical value. Finding geo-heritage locations and assessing their historical significance is the primary objective of the paper. Having been abandoned, these locations are unable to enlighten tourists about the region's past. About the locations that exist in these places, there is no information or museum. These objectives guide the conduct of the investigation, and the present paper presents the proper metrics and findings.
Analisis Kinerja Layanan Direktorat Kemahasiswaan Terhadap Kepuasan Mahasiswa Universitas Bina Darma Palembang
Authors: Aliya Sabeli , Permata Sari Siska
Published: January 2025

Penelitian ini bertujuan untuk menganalisis kinerja layanan Direktorat Kemahasiswaan dan pengaruhnya terhadap kepuasan mahasiswa di Universitas Bina Darma Palembang. Penelitian menggunakan metode kuantitatif dengan pendekatan deskriptif. Populasi dalam penelitian ini adalah seluruh mahasiswa Angkatan 2021-2024 Fakultas Sosial Humaniora, Universitas Bina Darma. Sampel penelitian terdiri dari 184 mahasiswa yang dipilih menggunakan teknik simple random sampling, dengan acuan penghitungan berdasarkan tabel Isaac dan Michael. Data dikumpulkan menggunakan kuesioner dengan skala Likert dan dianalisis menggunakan SPSS versi 22, meliputi uji validitas, reliabilitas, dan analisis deskriptif. Hasil penelitian menunjukkan bahwa dimensi layanan meliputi tangibles, reliability, responsiveness, assurance, dan empathy memiliki pengaruh positif terhadap kepuasan mahasiswa, dengan rata-rata skor tingkat kepuasan berkisar antara 4,20 hingga 4,69. Dimensi empathy memperoleh nilai tertinggi sebesar 4,69, sedangkan dimensi tangibles memiliki nilai terendah sebesar 4,20. Simpulan penelitian ini mengungkapkan bahwa mahasiswa secara umum puas dengan kinerja layanan Direktorat Kemahasiswaan, meskipun terdapat peluang perbaikan pada dimensi tangibles untuk meningkatkan kualitas layanan secara keseluruhan.
Peran Sistem Informasi Manajemen Bank Syariah Indonesia Dalam Membantu Peningkatan Perekonomian Dan Bisnis di Era Digital
Authors: Soleha Safnah , Sibuea Parulian , Yunanda Mey , Harahap Indah Tri Sari , Nasution Alya Arianti
Published: January 2025

The purpose of this research is to find out the role of the management information system of Indonesian Islamic banks in helping to improve the economy and business in the digital era, Bank Syariah Indonesia is encouraged to be able to compete at the global level in national economic development and contribute to the welfare of society, with a modern and universal concept. The type of research used in this paper is to use literature studies obtained from several sources. The results of the study The role of sharia banks in economic progress is that sharia banking in its operations emphasizes controlling the level of productivity according to financing including mudharabah and musyarakah. BSI's support and services for SMEs give entrepreneurs the opportunity to expand their business without having to use online loans or other high-interest loans that can exacerbate problems during a prolonged business crisis. The role of Management Information Systems in Islamic banking is significant in supporting the goal of a more inclusive and equitable economy
Dampak Servant Leadership Terhadap Innovative Work Behavior
Authors: Handayani Ririn , Surya Muhammad , Oemar Fahmi
Published: January 2025

The research was conducted at the Representative BPK of Riau Province, with the aim of testing the role of psychological empowerment and job crafting in mediating the influence of service leadership on innovative work behavior. The population of this study was 155 people. Based on this population size, in accordance with the Krejcie and Morgan (1970) table, the sample size for this study was 108 people. The sampling method used in this research is Systematic Random Sampling. All respondents will be used to obtain primary data related to the variables, which will be collected through a questionnaire with a 1-5 point Likert scale. All data obtained will be analyzed using Structural Equation Modeling (SEM) with the Smart PLS 3.0 analysis tool. This research found that service leadership has a positive effect on innovative work behavior; service leadership has a significant positive effect on psychological empowerment; Psychological empowerment has a significant positive effect on job crafting; Job crafting has a significant positive effect on innovative work behavior; Servant leadership is related to innovative work behavior through the sequential mediating effects of psychological empowerment and job crafting.
Kualitas Pelayanan Terhadap Kepuasan Pelanggan Di Optik Minang Bukitinggi
Authors: Novalinda Rina
Published: January 2025

This research design uses descriptive quantitative methods. The population in this study were consumers at Optik Minang Bukittinggi from 16 July to 19 July 2024. Data was collected through a research questionnaire using a checklist. The research results showed that respondents did not fully understand the importance of service quality on customer satisfaction. A total of 44 respondents (86.3%) were satisfied with the quality of service at Optik Minang and 7 respondents (13.7%) were dissatisfied with the quality of service at Optik Minang. Based on the results of this research, there are several suggestions submitted to (1) Optical Owners are expected to continue to maintain and improve the quality of service (2) ROs are expected to work professionally (3) Optical Refraction Academy is expected to be used as scientific information material in the field of Optical Refraction. (4) For future researchers, the author hopes that further research can be carried out with other independent variables so that more variables that influence consumer satisfaction at Optik can be identified.
Pengaruh Brand Image Dan Price Terhadap Purchase Intention Pelanggan Nadifa Mart Dengan Trust Sebagai Variabel Mediasi
Authors: Oktadelfia Sintia , Yolanda Mike
Published: January 2025

The aim of this research is to analyze (1) the influence of brand image on Nadfa Mart customer trust. (2) The influence of price on Nadfa Mart customer trust. (3) the influence of brand image on the purchase intention of Nadfa Mart customers. (4) the influence of price on the purchase intention of Nadfa Mart customers. (5) the influence of trust on the purchase intention of Nadifa Mart customers. (6) The influence of brand image on the trust of Nadfa Mart customers.( 6) the influence of brand image on purchase intention of Nadfa Mart customers with trust as a mediating variable. (7) the influence of price on purchase intention of Nadfa Mart customers with trust as a mediating variable.
       This type of research is quantitative descriptive research. Using purposive sampling, 120 respondents became the research sample. SEM analysis was carried out using the Smart PLS 4 tool.
              The results of this research are (1) there is a significant influence between brand image on Nadfa Mart customer trust. (2) There is a significant influence between price on Nadfa Mart customer trust. (3) there is a significant influence between brand image on the purchase intention of Nadfa Mart customers. (4) There is a significant influence between price on the purchase intention of Nadfa Mart customers. (5) There is a significant influence between trust on the purchase intention of Nadfa Mart customers. (6) There is significant influence between brand image on purchase intention of Nadfa Mart customers with trust as a mediating variable. (7) there is a significant influence between price on the purchase intention of Nadifa Mart customers and trust as a mediating variable.