bluuebunny/crossref_metadata_2025 huggingface dataset:
Propagation Program of Superior Coconut Varieties in Indonesia to Save Coconut Industries & Farmer’s Livelihood
Authors: Novarianto Hengky
Published: September 2023

Coconut palms are classified into two types, namely Tall and Dwarf, and hybrid and semi-tall types. By breeding activities, such as the selection of coconut germplasm, evaluation and utilization in the coconut breeding program, the IPCRI-IAARD has released 52 varieties of coconut until 2022, consisting of Talls, Dwarfs, Hybrids, and Semi Tall types has been used in coconut development programs. The potential of good local tall seedlings is around 6.0 million seednuts in 37 Provinces of Indonesia. Dwarf coconut type because it is short and the fruit is small, is used for tender coconuts and coconut sugar production. The hybrid coconut varieties are more suitable for private sectors because hybrid palms require high inputs. The tall coconut varieties that are suitable as raw material for the coconut industry include are mostly planted by smallholders. The varieties of Dwarf Pandan Wangi, Dwarf Pandan Manis, Dwarf Entoq Kebumen and Kopyor coconut are very suitable for tender coconut and mixed refreshment drinks. The IPCRI-IAARD has collaborated with several private sectors to supply hybrid coconut seedlings, and help them to establish their own seed garden. Various strategies for providing Tall, Dwarf, Hybrid and Semi-Tall coconut seedlings are expected to increase coconut production and productivity, and can supply raw material to coconut industry. Introduction
Narrowing the Yield Gap of Coconut (Cocos Nucifera L.) Through Integrated Nutrient Management in the Philippines: An On-Farm Experiment Approach
Authors: Crisostomo Speedy D , Cruz Christopher DV Dela , Quilloy Reynaldo B , Reaño Consorcia E
Published: September 2023

Over the years, coconut farmers are facing an inherent problem of low productivity in the Philippines due to the senile palms, poor agronomic practices, and other environmental factors. Fertilizer application is not typically practiced in most coconut plantations resulting in yield gaps of 31 to 87% between farmers’ fields and well-managed farms. We aimed to show the potential of integrated nutrient management (INM) in improving coconut productivity and narrowing the yield gap. In this study, five fertilizer treatments viz. T1 - farmer’s practice, T2 - 100% Philippine Coconut Authority’s recommended fertilizer rate (RFR) at two equal splits, applied semi-annually, T3 - 100% RFR at four equal splits, applied quarterly, T4 - 1/2 RFR at two equal splits, applied semi-annually plus one-time application of MykoVAM™, and T5 - 1/2 RFR at four equal splits, applied quarterly plus one-time application of MykoVAM™ were tested in four provinces to represent the four climate conditions in the Philippines. Each experimental site was carried out in a randomized complete block design with three replications. Nut yields from the on-farm experiments were used to analyze the different yield levels and yield gaps. The actual yields were lower than the attainable yields across all the locations. In terms of nut yield, Northern Samar had the highest yield gap of 68%, while Zamboanga City had the lowest yield gap with 21% difference. The exploitable yield gaps were 8,113, 9,408, 2,649 and 3,203 nuts/ha in Palawan, Northern Samar, Zamboanga City and Davao City, respectively. Results suggested that the indigenous soil nutrient content in the farmer’s field was not sufficient to supply the nutrient requirement of the crop compared to the attainable yield. INM has a potential in improving the nut yield. Thus, nutrient management plays a key role in closing the yield gap and in achieving high productivity.
Effect of glass powder on mechanical properties and durability of modified polystyrene particle concrete
Authors: Yu Zhouping , Yang Weijun , Cai Jiahang
Published: September 2023

In this paper, glass powder (GP) was used as a partial replacement of cement and the effects of different levels of GP replacement on the mechanical and durability properties of modified polystyrene particle concrete were investigated, and the mechanism of action was analysed using x-ray diffraction, scanning electron microscopy and CT techniques. The study results show that GP reduces the early strength of modified polystyrene particle concrete. When the substitution rate of GP is not more than 20%, it can improve the late compressive strength and splitting tensile strength of modified polystyrene granular concrete and enhance the chloride ion permeability and frost resistance. When the substitution rate of GP reaches 30% and above, it is unfavourable to the mechanical properties and durability of modified polystyrene granular concrete.20% is the best substitution rate of GP in modified polystyrene grainy concrete. The thermal conductivity of modified polystyrene particulate concrete tends to decrease and then increase with the increase of the GP substitution rate. The best thermal performance is achieved when the GP substitution rate is 10%. It can be attributed to the fact that the appropriate amount of GP can improve the internal microstructure of the modified polystyrene particle concrete and optimise the pore structure.
Recent developments in sustainable EM wave shielding composites- review
Authors: Prabhu Prashant M , Shivamurthy B , M Sathish Kumar
Published: September 2023

Due to technological advancements, there is tremendous demand for electronic gadgets essential for daily life. These gadgets emit electromagnetic radiation (EMR), harming the health of people in regular contact with these gadgets and creating electromagnetic interference (EMI) in neighboring electronic devices. EMI deteriorates the intended functions of the gadgets. Hence, electronic devices require EM radiation shielding. In this context, synthetic polymer composites become alternative materials to metal due to many advantages. However, synthetic polymer composites are non-degradable, and disposal once after usage is problematic. From this point of view, researchers further proposed biodegradable EM radiation shielding materials. In this regard, the advanced status of research on biodegradable EM radiation shielding authors has been presented in recent research reviews in this article. Mainly, the EM radiation shielding mechanisms and different types of bio-degradable EM radiation shielding materials recently developed by various researchers are reported. The salient features of the research review and the scope for further research are also discussed.
Scalp bacterial species influence SIRT1 and TERT expression in keratinocytes
Authors: Yamada Azusa , Watanabe Kota , Nishi Yuri , Oshiro Mugihito , Katakura Yoshinori , Sakai Kenji , Tashiro Yukihiro
Published: September 2023

Scalp bacteria on the human scalp and scalp hair comprise distinct community structures for sites and individuals. To evaluate their effect on human keratinocyte cellular activity, including that of the hair follicular keratinocytes, the expression of several longevity genes was examined using HaCaT cells. A screening system that uses enhanced green fluorescent protein (EGFP) fluorescence was established to identify scalp bacteria that enhance silent mating type information regulation 2 homolog-1 (SIRT1) promoter activity in transformed HaCaT cells (SIRT1p-EGFP). The results of quantitative polymerase chain reaction revealed that several predominant scalp bacteria enhanced (Cutibacterium acnes and Pseudomonas lini) and repressed (Staphylococcus epidermidis) the expressions of SIRT1 and telomerase reverse transcriptase (TERT) genes in HaCaT cells. These results suggest that the predominant scalp bacteria are related to the health of the scalp and hair, including repair of the damaged scalp and hair growth, by regulating gene expression in keratinocytes.
On-demand low-frequency stimulation for seizure control: efficacy and behavioural implications
Authors: Paschen Enya , Kleis Piret , Vieira Diego M , Heining Katharina , Boehler Christian , Egert Ulrich , Häussler Ute , Haas Carola A
Published: September 2023

Mesial temporal lobe epilepsy (MTLE), the most common form of focal epilepsy in adults, is often refractory to medication and associated with hippocampal sclerosis. Deep brain stimulation represents an alternative treatment option for drug-resistant patients who are ineligible for resective brain surgery. In clinical practice, closed-loop stimulation at high frequencies is applied to interrupt ongoing seizures, yet has (i) a high incidence of false detections; (ii) the drawback of delayed seizure-suppressive intervention; and (iii) limited success in sclerotic tissue. As an alternative, low-frequency stimulation (LFS) has been explored recently in patients with focal epilepsies. In preclinical epilepsy models, hippocampal LFS successfully prevented seizures when applied continuously.

Since it would be advantageous to reduce the stimulation load, we developed a protocol for on-demand LFS. Given the importance of the hippocampus for navigation and memory, we investigated potential consequences of LFS on hippocampal function. To this end, we used the intrahippocampal kainate mouse model, which recapitulates the key features of MTLE, including spontaneous seizure activity and hippocampal sclerosis. Specifically, our online detection algorithm monitored epileptiform activity in hippocampal local field potential recordings and identified short epileptiform bursts preceding focal seizure clusters, triggering hippocampal LFS to stabilize the network state. To probe behavioural performance, we tested the acute influence of LFS on anxiety-like behaviour in the light-dark box test, spatial and non-spatial memory in the object location memory and novel object recognition test, as well as spatial navigation and long-term memory in the Barnes maze.

On-demand LFS was almost as effective as continuous LFS in preventing focal seizure clusters but with a significantly lower stimulation load. When we compared the behavioural performance of chronically epileptic mice to healthy controls, we found that both groups were equally mobile, but epileptic mice displayed an increased anxiety level, altered spatial learning strategy and impaired memory performance. Most importantly, with the application of hippocampal LFS before behavioural training and test sessions, we could rule out deleterious effects on cognition and even show an alleviation of deficits in long-term memory recall in chronically epileptic mice. Taken together, our findings may provide a promising alternative to current therapies, overcoming some of their major limitations, and inspire further investigation of LFS for seizure control in focal epilepsy syndromes.
Timing and Predictors of Loss of Infectivity Among Healthcare Workers With Mild Primary and Recurrent COVID-19: A Prospective Observational Cohort Study
Authors: Dzieciolowska Stefania , Charest Hugues , Roy Tonya , Fafard Judith , Carazo Sara , Levade Ines , Longtin Jean , Parkes Leighanne , Beaulac Sylvie Nancy , Villeneuve Jasmin , Savard Patrice , Corbeil Jacques , De Serres Gaston , Longtin Yves
Published: September 2023

Background

There is a need to understand the duration of infectivity of primary and recurrent coronavirus disease 2019 (COVID-19) and identify predictors of loss of infectivity.

Methods

Prospective observational cohort study with serial viral culture, rapid antigen detection test (RADT) and reverse transcription polymerase chain reaction (RT-PCR) on nasopharyngeal specimens of healthcare workers with COVID-19. The primary outcome was viral culture positivity as indicative of infectivity. Predictors of loss of infectivity were determined using multivariate regression model. The performance of the US Centers for Disease Control and Prevention (CDC) criteria (fever resolution, symptom improvement, and negative RADT) to predict loss of infectivity was also investigated.

Results

In total, 121 participants (91 female [79.3%]; average age, 40 years) were enrolled. Most (n = 107, 88.4%) had received ≥3 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine doses, and 20 (16.5%) had COVID-19 previously. Viral culture positivity decreased from 71.9% (87/121) on day 5 of infection to 18.2% (22/121) on day 10. Participants with recurrent COVID-19 had a lower likelihood of infectivity than those with primary COVID-19 at each follow-up (day 5 odds ratio [OR], 0.14; P < .001]; day 7 OR, 0.04; P = .003]) and were all non-infective by day 10 (P = .02). Independent predictors of infectivity included prior COVID-19 (adjusted OR [aOR] on day 5, 0.005; P = .003), an RT-PCR cycle threshold [Ct] value <23 (aOR on day 5, 22.75; P < .001) but not symptom improvement or RADT result.

The CDC criteria would identify 36% (24/67) of all non-infectious individuals on day 7. However, 17% (5/29) of those meeting all the criteria had a positive viral culture.

Conclusions

Infectivity of recurrent COVID-19 is shorter than primary infections. Loss of infectivity algorithms could be optimized.
Spatio-temporal variations of seismic coupling along a transform fault: the western North Anatolian Fault Zone
Authors: Amemoutou Amandine , Martínez-Garzón Patricia , Durand Virginie , Kwiatek Grzegorz , Bohnhoff Marco , Dresen Georg
Published: September 2023

The Main Marmara Fault (MMF) forms a major segment of the North Anatolian Fault Zone (NAFZ) in northwestern Türkiye. The MMF represents a seismic gap with currently high seismic hazard and associated risk for the Istanbul metropolitan area. Here we estimate the seismic coupling defined as the ratio of the seismic strain rate to the tectonic strain rate, for the MMF and adjacent NAFZ segments. This ratio indicates the fraction of total strain accumulated with time that is released seismically. We compare the results of seismic strain rates and coupling estimated from earthquakes included in historical and instrumental catalogues, which allows us to identify fault segments that represent a considerable seismic threat during the current seismic cycle. We find that along the main fault traces hosting the large events, seismic strain rates from the historical catalogue are of the same order as the tectonic strain rates. In contrast, coupling estimates based on seismic data from the instrumental catalogue covering also off-fault areas, are up to 100 times smaller, highlighting that most of the seismic energy is released in large earthquakes with recurrence times longer than the time covered by the instrumental catalogue. Within the Sea of Marmara, a significant portion (48%) of shear strain from the instrumental catalogue is currently being accommodated by seismic deformation. Significant variations of the seismic coupling are observed before and after the 1999 M > 7 Izmit earthquake, highlighting the different contribution of aseismic slip over different portions of the seismic cycle. A comparison of the temporal evolution of the 1999 Izmit and Düzce post-seismic deformation with seismic strain rates shows that the largest seismic strain rates coincide with the largest post-seismic deformation.
Primary Exposure to SARS-CoV-2 via Infection or Vaccination Determines Mucosal Antibody-Dependent ACE2 Binding Inhibition
Authors: Fröberg Janeri , Koomen Vera J C H , van der Gaast-de Jongh Christa E , Philipsen Ria , GeurtsvanKessel Corine H , de Vries Rory D , Baas Marije C , van der Molen Renate G , de Jonge Marien I , Hilbrands Luuk B , Huynen Martijn A , Diavatopoulos Dimitri A
Published: September 2023

Background

Mucosal antibodies play a critical role in preventing SARS-CoV-2 infections or reinfections by blocking the interaction of the receptor-binding domain (RBD) with the angiotensin-converting enzyme 2 (ACE2) receptor on the cell surface. In this study, we investigated the difference between the mucosal antibody response after primary infection and vaccination.

Methods

We assessed longitudinal changes in the quantity and capacity of nasal antibodies to neutralize the interaction of RBD with the ACE2 receptor using the spike protein and RBD from ancestral SARS-CoV-2 (Wuhan-Hu-1), as well as the RBD from the Delta and Omicron variants.

Results

Significantly higher mucosal IgA concentrations were detected postinfection vs postvaccination, while vaccination induced higher IgG concentrations. However, ACE2-inhibiting activity did not differ between the cohorts. Regarding whether IgA or IgG drove ACE2 inhibition, infection-induced binding inhibition was driven by both isotypes, while postvaccination binding inhibition was mainly driven by IgG.

Conclusions

Our study provides new insights into the relationship between antibody isotypes and neutralization by using a sensitive and high-throughput ACE2 binding inhibition assay. Key differences are highlighted between vaccination and infection at the mucosal level, showing that despite differences in the response quantity, postinfection and postvaccination ACE2 binding inhibition capacity did not differ.
Green tissue-targeted expression of the Cry1Ab/c gene in transgenic maize using the Cre/loxP system as an alternative strategy against lepidopteran pests
Authors: Yuan Guangsheng , Shi Jiaxin , Shi Jiahao , He Dandan , Li Youliang , Du Juan , Zou Chaoying , Ma Langlang , Pan Guangtang , Shen Yaou
Published: September 2023

Genetically modified (GM) proteins in edible tissues of transgenic maize are of intense public concern. We provided a Cre/loxP-based strategy for manipulating the expression of transgenes in green tissues while locking them in nongreen tissues. First, the Cre gene was driven by the green tissue-specific promoter Zm1rbcS to generate transgenic maize KEY. Meanwhile, a gene cassette containing a Nos terminator (NosT) in front of the Cry1Ab/c gene was driven by the strong promoter ZmUbi to generate another transgenic maize LOCK. By crossing KEY and LOCK plants, the expressed Cre recombinase under the control of the Zm1rbcS promoter from KEY maize accurately removed the NosT of LOCK maize. Consequently, the expression of blocked Cry1Ab/c was enabled in specific green tissues in their hybrids. The expression level and concentration of Cry1Ab/c were observed using a strategy with high specific accumulation in green tissues (leaf and stem). Still, only a small or absent amount was observed in root and kernel tissues. Furthermore, we assessed the bioactivity of transgenic maize against 2 common lepidopteran pests, Ostrinia furnacalis and Spodoptera frugiperda, in the laboratory and field. The transgenic plants showed high plant resistance levels against the 2 pests, with mortality rates above 97.2% and damage scales below 2.2 compared with the control group. These findings are significant for exploring novel genetic engineering techniques in GM maize and providing a feasible strategy for transgenes avoiding expression in edible parts. In addition, implementing the Cre/loxP-mediated system could relieve public sentiment toward the biosafety of GM plants.
Investigation on interaction effects of multiple factors on clean gas extraction: implementation of response surface methodology
Authors: Zheng Chunshan , Wu Haifei , Jiang Bingyou , Xue Sheng , Zhao Yang
Published: September 2023

Gas-related disasters have become a major threat to mining safety of coal resources. Investigation into the optimization approach for inseam borehole gas extraction is important for improving extraction efficiency. By establishing control equations for coal seam deformation, porosity-permeability properties, and gas flow, effects of extraction time, initial gas pressure, initial coal permeability, and borehole diameter on gas flow pattern and effective extraction radius are analyzed. Based on response surface methodology and orthogonal experimental design, a regression analysis model of effective extraction radius and multiple influencing factors is established. Meanwhile, the interaction mechanism between effects of multiple factors is analyzed, thus identifying optimal parameters for gas extraction. Results show that effective extraction radius is positively correlated with initial permeability, extraction time, and borehole diameter, and negatively associated with original gas pressure. In terms of effect on effective extraction radius, those parameters could be ranked as follows: initial gas pressure, extraction time, initial coal permeability, then borehole diameter. Interaction between multiple factors could inhibit the impact of individual factors on extraction radius. An increase in initial gas pressure reduces the positive effect of permeability on extraction radius. Growing initial gas pressure inhibits the contribution of extraction time to effective drainage radius. Prolonged duration of extraction suppresses the positive effect of permeability on extraction radius. Interaction between initial gas pressure and initial permeability has the most significant influence on extraction radius. Results from orthogonal experimental design correspond to those of response surface methodology. These findings could provide guidance for dynamically adjusting drilling extraction parameters and improving gas-extraction outcomes.
DIW-based reflection full waveform inversion and its application of land seismic data
Authors: Hu Guanghui , Xu Wencai , He Binghong , He Weiguang , Du Zeyuan , Yao Jiashun
Published: September 2023

The exploration zone in Northwest China poses unique challenges due to its complex structures, fractured blocks, deep reservoirs, and geological anomalies. Conventional velocity modeling and migration imaging methods face difficulties in accurately imaging the underlying reservoirs beneath abnormal rock formations, resulting in poor signal-to-noise ratio and resolution. Moreover, the seismic data quality often falls short, leading to unfocused images. To address these challenges, we propose a novel approach: dynamic image warping-based reflection full waveform inversion. This method combines a model regularization strategy and structural constraints to generate high-resolution velocity models. The application in the Taha Industrial Zone demonstrates that the proposed method effectively characterizes the velocity characteristics of special geological bodies, such as deep weathering crusts, improving imaging effects and resolution, which allows for a more precise understanding of the complex geological features.
Validating a model for predicting breast cancer and nonbreast cancer death in women aged 55 years and older
Authors: Wolfson Emily A , Schonberg Mara A , Eliassen A Heather , Bertrand Kimberly A , Shvetsov Yurii B , Rosner Bernard A , Palmer Julie R , LaCroix Andrea Z , Chlebowski Rowan T , Nelson Rebecca A , Ngo Long H
Published: September 2023

Background

To support mammography screening decision making, we developed a competing-risk model to estimate 5-year breast cancer risk and 10-year nonbreast cancer death for women aged 55 years and older using Nurses’ Health Study data and examined model performance in the Black Women’s Health Study (BWHS). Here, we examine model performance in predicting 10-year outcomes in the BWHS, Women’s Health Initiative-Extension Study (WHI-ES), and Multiethnic Cohort (MEC) and compare model performance to existing breast cancer prediction models.

Methods

We used competing-risk regression and Royston and Altman methods for validating survival models to calculate our model’s calibration and discrimination (C index) in BWHS (n = 17 380), WHI-ES (n = 106 894), and MEC (n = 49 668). The Nurses’ Health Study development cohort (n = 48 102) regression coefficients were applied to the validation cohorts. We compared our model’s performance with breast cancer risk assessment tool (Gail) and International Breast Cancer Intervention Study (IBIS) models by computing breast cancer risk estimates and C statistics.

Results

When predicting 10-year breast cancer risk, our model’s C index was 0.569 in BWHS, 0.572 in WHI-ES, and 0.576 in MEC. The Gail model’s C statistic was 0.554 in BWHS, 0.564 in WHI-ES, and 0.551 in MEC; IBIS’s C statistic was 0.547 in BWHS, 0.552 in WHI-ES, and 0.562 in MEC. The Gail model underpredicted breast cancer risk in WHI-ES; IBIS underpredicted breast cancer risk in WHI-ES and in MEC but overpredicted breast cancer risk in BWHS. Our model calibrated well. Our model’s C index for predicting 10-year nonbreast cancer death was 0.760 in WHI-ES and 0.763 in MEC.

Conclusions

Our competing-risk model performs as well as existing breast cancer prediction models in diverse cohorts and predicts nonbreast cancer death. We are developing a website to disseminate our model.
The inefficiency of stellar feedback in driving galactic outflows in massive galaxies at high redshift
Authors: Bassini Luigi , Feldmann Robert , Gensior Jindra , Hayward Christopher C , Faucher-Giguère Claude-André , Cenci Elia , Liang Lichen , Bernardini Mauro
Published: September 2023

Recent observations indicate that galactic outflows are ubiquitous in high-redshift (high-z) galaxies, including normal star-forming galaxies, quasar hosts, and dusty star-forming galaxies (DSFGs). However, the impact of outflows on the evolution of their hosts is still an open question. Here, we analyse the star-formation histories and galactic outflow properties of galaxies in massive haloes ($10^{12}\, {\rm M}_{\odot }\ \lt\ M_{\rm vir}\ \lt\ 5\times 10^{12}\, {\rm M}_{\odot }$) at z ≳ 5.5 in three zoom-in cosmological simulations from the MassiveFIRE suite, as part of the Feedback In Realistic Environments (FIRE) project. The simulations were run with the FIRE-2 model, which does not include feedback from active galactic nuclei. The simulated galaxies resemble z > 4 DSFGs, with star-formation rates of $\sim\!{1000}\ {\rm M}_{\odot }\, \rm yr^{-1}$ and molecular gas masses of Mmol ∼ 1010 M⊙. However, the simulated galaxies are characterized by higher circular velocities than those observed in high-z DSFGs. The mass loading factors from stellar feedback are of the order of ∼0.1, implying that stellar feedback is inefficient in driving galactic outflows and gas is consumed by star formation on much shorter time-scales than it is expelled from the interstellar medium. We also find that stellar feedback is highly inefficient in self-regulating star formation in this regime, with an average integrated star formation efficiency (SFE) per dynamical time of 30 per cent. Finally, compared with FIRE-2 galaxies hosted in similarly massive haloes at lower redshift, we find lower mass loading factors and higher SFEs in the high-z sample. We argue that both effects originate from the higher total and gas surface densities that characterize high-z massive systems.
Punctuated chaos and the unpredictability of the Galactic Centre S-star orbital evolution
Authors: Portegies Zwart Simon F , Boekholt Tjarda C N , Heggie Douglas C
Published: September 2023

We investigate the chaotic behaviour of the S-star cluster in the Galactic Centre using precise N-body calculations, free from round-off or discretization errors. Our findings reveal that chaos among the Galactic Centre S-stars arises from close encounters, particularly among pairs and near the massive central body. These encounters induce perturbations, causing sudden changes in the orbital energies of the interacting stars. Consequently, neighbouring solutions experience roughly exponential growth in separation. We propose a theory of ‘punctuated chaos’ that describes the S-star cluster’s chaotic behaviour. This phenomenon results from nearly linear growth in the separation between neighbouring orbits after repeated finite perturbations. Each participating star’s orbit experiences discrete, abrupt changes in energy due to the perturbations. The cumulative effect of these events is further amplified by the steady drift in orbital phase. In the Galactic Centre, perturbations originate from coincidental encounters occurring within a distance of ≲100 au between at least two stars (in some cases, three stars). Our model satisfactorily explains the observed exponential growth in the 27 S-stars cluster. We determine that the S-star system has a Lyapunov time-scale of approximately 462 ± 74 yr. For the coming millennium, chaos in the S-star cluster will be driven mainly by a few of the closest orbiting stars: S2, S5, S6, S8, S9, S14, S18, S31, S21, S24, S27, S29, and S38.
Discovery of compact disc galaxies with high-surface brightness in the Sloan Digital Sky Survey
Authors: Chen Cheng-Yu , Hwang Chorng-Yuan
Published: September 2023

Compact disc galaxies (CDGs) with high-surface brightness were identified in the Sloan Digital Sky Survey data. We determined the surface profiles of the CDGs and compared them to those of normal-sized disc galaxies (NDGs). The CDGs have higher central brightness and older stellar age than the NDGs. Furthermore, the brightness profiles of the CDGs fit a Sérsic model with n ≈ 2.11 and have a zero g′ − r′ colour gradient on average. By contrast, the NDGs fit an exponential profile and have a negative colour gradient on average. These results indicate that the structure and stellar population of the CDGs and NDGs differ. We suggest that the CDGs are ancient galaxies in the quenching phase following the initial central starburst.
Formation of first star clusters under the supersonic gas flow – I. Morphology of the massive metal-free gas cloud
Authors: Hirano Shingo , Shen Youcheng , Nishijima Sho , Sakai Yusuke , Umeda Hideyuki
Published: September 2023

We performed 42 simulations of first star formation with initial supersonic gas flows relative to the dark matter at the cosmic recombination era. Increasing the initial streaming velocities led to delayed halo formation and increased halo mass, enhancing the mass of the gravitationally shrinking gas cloud. For more massive gas clouds, the rate of temperature drop during contraction, in other words, the structure asymmetry, becomes more significant. When the maximum and minimum gas temperature ratios before and after contraction exceed ∼10, the asymmetric structure of the gas cloud prevails, inducing fragmentation into multiple dense gas clouds. We continued our simulations until 105 yr after the first dense core formation to examine the final fate of the massive star-forming gas cloud. Among the 42 models studied, we find the simultaneous formation of up to four dense gas clouds, with a total mass of about $2254\, \mathrm{ M}_\odot$. While the gas mass in the host halo increases with increasing the initial streaming velocity, the mass of the dense cores does not change significantly. The star formation efficiency decreases by more than one order of magnitude from ϵIII ∼ 10−2 to 10−4 when the initial streaming velocity, normalized by the root mean square value, increases from 0 to 3.
Interlocus Gene Conversion, Natural Selection, and Paralog Homogenization
Authors: Yang Yixuan , Xu Tanchumin , Conant Gavin , Kishino Hirohisa , Thorne Jeffrey L , Ji Xiang
Published: September 2023

Following a duplication, the resulting paralogs tend to diverge. While mutation and natural selection can accelerate this process, they can also slow it. Here, we quantify the paralog homogenization that is caused by point mutations and interlocus gene conversion (IGC). Among 164 duplicated teleost genes, the median percentage of postduplication codon substitutions that arise from IGC rather than point mutation is estimated to be between 7% and 8%. By differentiating between the nonsynonymous codon substitutions that homogenize the protein sequences of paralogs and the nonhomogenizing nonsynonymous substitutions, we estimate the homogenizing nonsynonymous rates to be higher for 163 of the 164 teleost data sets as well as for all 14 data sets of duplicated yeast ribosomal protein-coding genes that we consider. For all 14 yeast data sets, the estimated homogenizing nonsynonymous rates exceed the synonymous rates.
Sustained post-rituximab B-cell depletion is common in ANCA-associated vasculitis and is affected by sex and renal function
Authors: Mescia Federica , Salviani Chiara , Tonoli Mattia , Affatato Stefania , Moratto Daniele , Tedesco Martina , Guerini Alice , Gemmo Alessia , Camoni Marta , Delbarba Elisa , Zubani Roberto , Garrafa Emirena , Chiarini Marco , Gregorini Gina , Scolari Francesco , Alberici Federico
Published: September 2023

Objective

Despite the increasing use of rituximab in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), it remains unclear what the optimal dosing is, especially for maintenance of remission. A deeper understanding of post-rituximab B-cell repopulation patterns may aid better-tailored treatment.

Methods

This is a monocentric, retrospective study including ANCA-positive AAV patients receiving a single course of rituximab induction. CD19+ B cells were longitudinally monitored with flow cytometry. B-cell repopulation was defined as CD19+ >10 cells/μL.

Results

Seventy-one patients were included, the majority with microscopic polyangiitis (75%), myeloperoxidase-ANCA positivity (75%) and with renal involvement (79%). During a median follow-up of 54 months since the first rituximab infusion, 44 patients (62%) repopulated B cells, with a median time to repopulation of 39 months (range 7–102). Patients experiencing B-cell depletion lasting longer than the overall median time to repopulation (39 months) exhibited a lower risk of flare and higher risk of serious infection. In multivariate Cox regression, higher estimated glomerular filtration rate (eGFR) [hazard ratio (HR) 1.84, 95% confidence interval (CI) 1.13–2.98 per 30 mL/min/1.73 m2 eGFR] and female sex (HR 2.70, 95% CI 1.37–5.31) were independent predictors of increased rate of B-cell repopulation.

Conclusion

A subset of AAV patients develop sustained post-rituximab B-cell depletion, which associates with reduced risk of flare and increased risk of serious infection in the long term. Preserved renal function and female sex are associated with faster B-cell repopulation. These observations further highlight the need to personalize immunosuppression to improve clinical outcomes.
N-body simulation of planetary formation through pebble accretion in a radially structured protoplanetary disk
Authors: Jinno Tenri , Saitoh Takayuki R , Ishigaki Yota , Makino Junichiro
Published: September 2023

In the conventional theory of planet formation, it is assumed that protoplanetary disks are axisymmetric and have a smooth radial profile. However, recent radio observations of protoplanetary disks have revealed that many of them have complex radial structures. In this study, we perform a series of N-body simulations to investigate how planets are formed in protoplanetary disks with radial structures. For this purpose, we consider the effect of continuous pebble accretion onto the discontinuity boundary within the terrestrial planet-forming region (∼0.6 au). We find that protoplanets grow efficiently at the discontinuity boundary, reaching the Earth mass within ∼104 yr. We confirm that giant collisions of protoplanets occur universally in our model. Moreover, we find that multiple planet-sized bodies form at regular intervals in the vicinity of the discontinuity boundary. These results indicate the possibility of the formation of solar system-like planetary systems in radially structured protoplanetary disks.
The paradoxical influence of the COVID-19 lockdown period on different types of preterm births in Alberta: a provincial study
Authors: Dosani Aliyah , Sikdar Khokan C , Kumaran Mahalakshmi , Kumaran Kumar , Hyderi Abbas , Benlamri Amina , Rai Baldeep , Singhal Nalini , Lodha Abhay
Published: September 2023

Objectives

The objective of this study was to determine if the COVID-19 pandemic impacted different types of preterm birth rates in Alberta, Canada.

Methods

A population-based, retrospective, cohort study was conducted from March 15, 2015 to December 31, 2020 using provincial data. The primary exposure was the COVID-19 lockdown period, and the primary outcome was the incidence of preterm birth (<37 weeks gestational age). Multivariable analyses in the complete lockdown and overall lockdown (partial and complete lockdown) periods were performed to test the association between the year of birth and preterm birth status and were adjusted for various independent variables. Preterm birth status was adjusted for various confounding factors.

Results

Following the analysis of n = 41,187 mothers and their singleton infants, we found that the lockdown due to COVID-19 had no impact in reducing the overall preterm birth rate. However, a paradoxical influence was observed with an increase of extremely low preterm births in the overall lockdown period, and a decrease in moderate preterm births during the complete lockdown period.

Conclusions

The results of this study demonstrated that there was a decrease in moderate and increase in extremely low preterm birth rates as a result of the COVID-19 lockdown. However, the COVID-19 lockdown did not impact the very preterm and late preterm birth rate in Alberta.
Transcriptomic Analysis Reveals Novel Regulators of the Scots Pine Stilbene Pathway
Authors: Paasela Tanja , Lim Kean-Jin , Pavicic Mirko , Harju Anni , Venäläinen Martti , Paulin Lars , Auvinen Petri , Kärkkäinen Katri , Teeri Teemu H
Published: September 2023

Stilbenes accumulate in Scots pine heartwood where they have important roles in protecting wood from decaying fungi. They are also part of active defense responses, and their production is induced by different (a)biotic stressors. The specific transcriptional regulators as well as the enzyme responsible for activating the stilbene precursor cinnamate in the pathway are still unknown. UV-C radiation was the first discovered artificial stress activator of the pathway. Here, we describe a large-scale transcriptomic analysis of pine needles in response to UV-C and treatment with translational inhibitors, both activating the transcription of stilbene pathway genes. We used the data to identify putative candidates for the missing CoA ligase and for pathway regulators. We further showed that the pathway is transcriptionally activated by phosphatase inhibitor, ethylene and jasmonate treatments, as in grapevine, and that the stilbene synthase promoter retains its inducibility in some of the tested conditions in Arabidopsis, a species that normally does not synthesize stilbenes. Shared features between gymnosperm and angiosperm regulation and partially retained inducibility in Arabidopsis suggest that pathway regulation occurs not only via ancient stress-response pathway(s) but also via species-specific regulators. Understanding which genes control the biosynthesis of stilbenes in Scots pine aids breeding of more resistant trees.
Ten Thousand Years of Magma Storage Preceding the Last Caldera-Forming Eruption of the Bandelier Magmatic System, New Mexico, USA
Authors: Meszaros Nicholas F , Gardner James E , Zimmerer Matthew J , Befus Kenneth S
Published: September 2023

In this study, we present new evidence for changes in magma storage conditions that preceded the 1232 ka caldera-forming eruption of the Bandelier magmatic system in the Jemez Mountains Volcanic Field. Using high precision 40Ar/39Ar sanidine dating we determine that at least eight rhyolites erupted within 8.6 ± 3.4 kyr of the ~400 km3 eruption that formed Valles caldera. Some of those rhyolites contain fayalite with or without biotite, others contain only biotite. An eruption of fayalite-bearing rhyolite at 1240.5 ± 2.1 ka ended an eruption hiatus of at least 100 kyr. Following that first post-hiatus episode of volcanism, at least four more eruptions of fayalite-bearing rhyolite and three eruptions of biotite-bearing rhyolite occurred prior to the caldera-forming eruption. We use phase equilibrium experiments and geothermobarometry to infer the storage conditions and processes that led to these differing crystal cargos and ultimately generated ~400 km3 of predominantly fayalite rhyolite ignimbrite (Tshirege Member of the Bandelier Tuff). We find that biotite-bearing rhyolites were stored at 695–750°C, 75–160 MPa, and at an oxygen fugacity more oxidizing than the quartz-fayalite-magnetite (QFM) buffer reaction. Fayalite-bearing rhyolites were similarly stored at 695–745°C and 70–190 MPa, but at more reducing conditions (${f}_{O_2}$≤ QFM). We suggest that the reduced, fayalite-bearing rhyolite was most likely produced via interaction of crystal-poor rhyolitic magma with a reducing, potentially Cl-bearing, and H2O-rich supercritical fluid phase. This fluid flux event was a key component of the substantial magmatic rejuvenation that enabled the mobilization of ~400 km3 of mostly fayalite-bearing rhyolite prior to not only the Tshirege event, but the older Otowi event as well.
Measuring Welfare and Inequality with Incomplete Price Information
Authors: Atkin David , Faber Benjamin , Fally Thibault , Gonzalez-Navarro Marco
Published: September 2023

We propose and implement a new approach that allows us to estimate income-specific changes in household welfare in contexts where well-measured prices are not available for important subsets of consumption. Using rich but widely available expenditure survey microdata, we show that we can recover income-specific equivalent and compensating variations from horizontal shifts in what we call “relative Engel curves”—as long as preferences fall within the broad quasi-separable class (Gorman 1970, 1976). Our approach is flexible enough to allow for nonparametric estimation at each point of the income distribution. We apply the methodology to estimate inflation and welfare changes in rural India between 1987 and 2000. Our estimates reveal that lower rates of inflation for the rich erased the real income convergence found in the existing literature that uses the subset of consumption with well-measured prices to calculate inflation.
Lymphocyte subset phenotyping for the prediction of progression to inflammatory arthritis in anti-citrullinated-peptide antibody-positive at-risk individuals
Authors: Anioke Innocent , Duquenne Laurence , Parmar Rekha , Mankia Kulveer , Shuweihdi Farag , Emery Paul , Ponchel Frederique
Published: September 2023

Objectives

Inflammatory arthritis (IA) is considered the last stage of a disease continuum, where features of systemic autoimmunity can appear years before clinical synovitis. Time to progression to IA varies considerably between at-risk individuals, therefore the identification of biomarkers predictive of progression is of major importance. We previously reported on the value of three CD4+T cell subsets as biomarkers of progression. Here, we aim to establish the value of 18 lymphocyte subsets (LS) for predicting progression to IA.

Methods

Participants were recruited based on a new musculoskeletal complaint and being positive for anti-citrullinated-peptide antibody. Progression (over 10 years) was defined as the development of clinical synovitis. LS analysis was performed for lymphocyte lineages, naive/memory subsets, inflammation-related cells (IRC) and regulatory cells (Treg/B-reg). Modelling used logistic/Cox regressions.

Results

Of 210 patients included, 93 (44%) progressed to IA, 41/93 (44%) within 12 months (rapid progressors). A total of 5/18 LS were associated with progression [Treg/CD4-naïve/IRC (adjusted P < 0.0001), CD8 (P = 0.021), B-reg (P = 0.015)] and three trends (NK-cells/memory-B-cells/plasmablasts). Unsupervised hierarchical clustering using these eight subsets segregated three clusters of patients, one cluster being enriched [63/109(58%)] and one poor [10/45(22%)] in progressors. Combining all clinical and LS variables, forward logistic regression predicted progression with accuracy = 85.7% and AUC = 0.911, selecting smoking/rheumatoid-factor/HLA-shared-epitope/tender-joint-count-78 and Treg/CD4-naive/CD8/NK-cells/B-reg/plasmablasts. To predict rapid progression, a Cox regression was performed resulting in a model combining smoking/rheumatoid factor and IRC/CD4-naive/Treg/NK-cells/CD8+T cells (AUC = 0.794).

Conclusion

Overall, progression was predicted by specific LS, suggesting potential triggers for events leading to the development of IA, while rapid progression was associated with a different set of subsets.
VIIShakespeare
Authors: Rendall Edward B M , Smith Peter J , Fairbanks Chloe , Stelzer Emanuel , Bell Shirley , Rivera Jennifer , O’brien Sheilagh Ilona , Baratta Luca
Published: September 2023

This chapter has four sections: 1. Editions and Textual Studies; 2. Shakespeare in the Theatre; 3. Shakespeare on Screen; 4. Criticism. Section 1 is by Edward B. M. Rendall; section 2 is by Peter J. Smith; section 3 will resume next year; section 4(a) is by Chloe Fairbanks; section 4(b) is by Emanuel Stelzer; section 4(c) is by Shirley Bell; section 4(d) will resume next year; section 4(e) is by Jennifer Rivera; section 4(f) is by Sheilagh Ilona O’Brien; section 4(g) is by Luca Baratta.
ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1‐DT and enhancing profilin 2 activation
Authors: Li Shuxin , Lv Jianyi , Zhang Xing , Zhang Qiuyu , Li Zhihui , Lu Jing , Huo Xueyun , Guo Meng , Liu Xin , Gao Ran , Gong Jianan , Li Changlong , Li Weiying , Zhang Tongmei , Wang Jinghui , Chen Zhenwen , Du Xiaoyan
Published: September 2023

Small cell lung cancer (SCLC) is one of the most malignant tumors that has an extremely poor prognosis. RNA‐binding protein (RBP) and long noncoding RNA (lncRNA) have been shown to be key regulators during tumorigenesis as well as lung tumor progression. However, the role of RBP ELAVL4 and lncRNA LYPLAL1‐DT in SCLC remains unclear. In this study, we verified that lncRNA LYPLAL1‐DT acts as an SCLC oncogenic lncRNA and was confirmed in vitro and in vivo. Mechanistically, LYPLAL1‐DT negatively regulates the expression of miR‐204‐5p, leading to the upregulation of PFN2, thus, promoting SCLC cell proliferation, migration, and invasion. ELAVL4 has been shown to enhance the stability of LYPLAL1‐DT and PFN2 mRNA. Our study reveals a regulatory pathway, where ELAVL4 stabilizes PFN2 and LYPLAL1‐DT with the latter further increasing PFN2 expression by blocking the action of miR‐204‐5p. Upregulated PFN2 ultimately promotes tumorigenesis and invasion in SCLC. These findings provide novel prognostic indicators as well as promising new therapeutic targets for SCLC.
Original Research: Oral Health Concerns of Female Breast Cancer Survivors on Adjuvant Endocrine Therapy
Authors: Park So-Hyun , Strauss Shiela M.
Published: September 2023

Background:

Oral complications from cancer treatments are among the adverse effects breast cancer survivors can face. Yet such complications are often overlooked in cancer survivorship care. Many breast cancer survivors are receiving adjuvant endocrine therapy, but there is limited understanding of potential oral complications from this therapy.

Purpose:

This study aimed to compare aspects of oral health in female breast cancer survivors who were taking adjuvant endocrine therapy with those of survivors not taking such therapy.

Methods:

National Health and Nutrition Examination Survey data collected from January 2009 through March 2020 were used for the analysis. Female adults ages 20 years and older who had been diagnosed with breast cancer were included. Linear regression and χ2 analyses were conducted to examine aspects of oral health, using IBM SPSS Complex Samples software, version 27.

Results:

In our sample of 423 female breast cancer survivors, 7.1% were taking tamoxifen, 7.8% were taking anastrozole, 4.3% were taking letrozole, and 2.9% were taking exemestane. Compared with the survivors not taking such therapy, a greater proportion of those taking it had decayed teeth, gum disease/problems, and were recommended for imminent dental care after oral health examination by dentists. The survivors who were not taking adjuvant endocrine therapy had more coronal cavities.

Conclusions:

Data analysis showed that female breast cancer survivors taking adjuvant endocrine therapy appear more likely to have oral health issues than those not taking such therapy. Improved awareness of these issues is critical. Assessment and management guidelines to address these oral health issues are needed by health care providers.