bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship with Emotional Intelligence and General Health among Male Smoker Staff in Urmia University of Medical Sciences
Authors: Yadegar Tirandaz Shima , Sahebihagh Mohammad Hasan , Namdar Areshtanab Hossein , Jafarizadeh Hossein , Asghari Jafarabadi Mohammad
Published: February 2020

Introduction: One of the important factors in determining success in life is emotional intelligence. It could be considered as a protective factor against health threatening behaviors, including smoking. Considering the effect of emotional intelligence on the health of people and the amount of smoking in smokers, the present study aimed to investigate the relationship between emotional intelligence and general health in the male smokers. Methods: In this descriptive-correlational study, 350 male smokers who were working in Uremia University of Medical Sciences were recruited, using convenience sampling. The instruments used in this study were demographic information questionnaires, Cyberia Shrink standard questionnaire, and 28-Question General Health Questionnaire (GHQ-28). Results: The mean score (SD) of emotional intelligence and the mean score (SD) of general health were 110.26 (16.24) and 23. 60 (13.27), respectively. There was a significant negative relationship between emotional intelligence and general health scores. Conclusion: Individuals with higher emotional intelligence scores had a better physical and mental health status. Therefore, teaching emotional intelligence can increase physical and mental health of the individuals through reducing risky behaviors.
A Comparison of The Effects of Clobetasol 0.05% and Photodynamic Therapy Using Aminolevulinic Acid With Red Light in the Treatment of Severe Nail Psoriasis
Authors: Tehranchinia Zohreh , Barzkar Nasibeh , Riahi Seyed Mohammad , Khazan Marjan
Published: February 2020

Introduction: The treatment of nail psoriasis is often difficult and unsatisfactory due to therapy resistance. This study aimed to compare the efficacy of clobetasol 0.05% ointment and photodynamic therapy (PDT) using aminolevulinic acid (ALA) and red light in the treatment of severe nail psoriasis. Methods: This open-trial study included 69 nails of 8 patients with severe nail psoriasis. Thirty-four nails were treated with clobetasol 0.05% ointment and 35 nails were treated with ALA-PDT. ALAPDT treatment was performed every 3 weeks for 5 cycles; the nails were treated with clobetasol under occlusion every day during the study. All the patients were followed up after 24 weeks. The severity of nail involvement was measured by the Nail Psoriasis Severity Index (NAPSI) scores at the baseline and during the treatment. Results: There were no significant differences in the NAPSI scores between the treatment groups in the baseline and weeks 3, 6 and 9 (all P>0.05), although significant differences were found in weeks 12, 15 and 24 (follow-up) (P<0.001). A significant time-effect improvement was found in all the nailmatrix, nail-bed and total NAPSI scores in both treatment groups (all P<0.001). The patients did not report intense pain and discomfort during irradiation. Conclusion: Clobetasol 0.05% ointment seems to be effective in treating nail psoriasis after a treatment period of 15 weeks. However, the efficacy of ALA-PDT at a 24-week follow-up was greater than that of clobetasol.
The Efficacy of Adding Electromagnetic Therapy or Laser Therapy to Medications in Patients With Diabetic Peripheral Neuropathy
Authors: Shanb Alsayed A. , Youssef Enas F. , Al Baker Waleed I. , Al-Khamis Fahd A. , Hassan Ali , Jatoi Noor-Ahmad
Published: February 2020

Introduction: Diabetes mellitus (DM) is a common disease with a highly significant burden among the Saudi population. This study aimed to investigate the effects of adding either magnetic or laser therapy to medications in patients with diabetic peripheral neuropathy (DPN). Methods: Seventy-one medically controlled diabetic patients were randomly assigned to 1) Magnetic group: 26 patients were exposed to magnetic therapy for 20 minutes/session, 2 sessions/week, for 3 months 2) Laser group: 25 patients were exposed to laser therapy with intensity 5.7 J/cm2 for 30 minutes/session, 2 times/week, for 3 months. 3) Drug group: 20 patients received only the regular medications for diabetic control and pain analgesia. Pain and neuropathy were assessed by the visual analog scale (VAS) and the Toronto Clinical Neuropath Scoring System (TRCNSS). Conduction velocities and amplitudes of peroneal and sural nerves were measured by electromyography. Results: The results showed significant increases in conduction velocities and amplitudes in both magnetic and laser groups in parallel with significant reductions in TRCNSS. Non-significant changes were obtained only after using only medications (P>0.05). The mean values of VAS reduced significantly in the three groups. The least significant differences showed significant changes among the three groups, whereas non-significant differences were obtained between both magnetic and laser groups. Conclusion: There were non-significant differences between both magnetic and laser therapy groups. Addition of either magnetic or laser therapy to medications could bring extra positive benefits to patients with DPN. Both magnetic and laser therapy can be applied with medications for the treatment of patients with DPN.
Juvenile Hyaline Fibromatosis Management With a Diode Laser: A Rare Case Report
Authors: Fekrazad Reza , Fazilat Farzad , Kalhori Katayoun AM , Hakimiha Neda , Amirmoini Mehrdad , Nikhalat Jahromi Maryam
Published: February 2020

Juvenile hyaline fibromatosis (JHF) is an unknown hereditary disorder with variable penetrance. The characterizations of this disease consist of different signs and symptoms such as multiple tumorous (tumor-like) muco-cutaneous proliferation, gingival hypertrophy, perianal lesions, articular contractures, and osteolytic lesions. A 3-year-old girl with numerous painless nodular masses on her gingival, ear and anal areas is presented in this case report. Based on characteristic histological features, the diagnosis of JHF was made. The patient underwent surgery following general anesthesia and the above areas were surgically operated with appropriate laser parameters, and the patient was able to eat and wash away after a day and was discharged with an antibiotic prescription after one day in the hospital and returned to normal after a week. The recurrence occurred in other areas a year later, especially in the cheek, the ears and the anal area. Therefore, this rare case is presented with recurrence.
The Immediate Pain-Relieving Effects of Non-Thermal CO2 Laser Therapy on Genital Ulcers of Behcet’s Disease: A Case Report
Authors: Zand Nasrin , Mansouri Parvin , Rezaee Khiabanloo Samad , Fateh Mohsen , Ataie-Fashtami Leila , Safaee Naraghi Zahra , Shirkavand Afshan
Published: February 2020

Behçet’s disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology. Oral and genital aphthous ulcers are considered as the hallmarks of BD. The genital ulcers of BD may be extremely painful and often refractory to multiple treatments. In addition, they exert a negative impact on the patient’s quality of life. Some investigations have demonstrated the significant and immediate pain-relieving effects of NTCLT (non-thermal CO2 laser therapy) on some oral lesions with no visible adverse effects. In this paper, we report a case of BD whose painful genital ulcers were irradiated with NTCLT and the patient’s pain caused by the ulcers relieved immediately and significantly with no visible complications.
Effect of Sintering Parameters on the Mechanical Properties of Monolithic Zirconia
Authors: Öztürk Caner , Can Gülşen
Published: February 2020

Background.
Zirconia restorations with high mechanical properties are the current treatment options for fixed restorations with advantages of high biocompatibility and low pulp irritation. Although the effect of sintering time and temperature on the optical and mechanical properties of zirconia core material were investigated, the effect of these parameters on the translucent monolithic zirconia is still uncertain. This study aimed to evaluate the effect of the changes in sintering temperature and holding time on the mechanical and structural properties of monolithic zirconia. Methods. Totally, 340 self-colored (A2) zirconia specimens from two different monolithic zirconia groups (n=170) were prepared, measuring 15.5×12.5×1.2 mm. Then, 17 subgroups (n=10), including the control groups, were sintered according to sintering parameters. XRD analysis was used to determine phase transformations. The surface roughness of the specimens was evaluated using profilometry, and the flexural strength of the specimens was evaluated by the three-point bending test. The data were analyzed using three-way ANOVA and post hoc multiple comparison test with Bonferroni correction (a=0.05) at a significance level of 0.05. Independent-samples t-test was used to compare the subgroups between the control groups (P˂0.05). Results. No tetragonal-to-monoclinic phase transformation was observed in the groups. Changes in the sintering parameters did not significantly affect the surface roughness and flexural strength of monolithic zirconia. Surface roughness values for all the subgroups were above the clinically critical limit. Conclusion. According to the results of this study, changes in the sintering parameters did not affect the surface phase transformation, surface roughness, and flexural strength of monolithic zirconia.
Octacalcium phosphate/gelatin composite facilitates bone regeneration of critical-sized mandibular defects in rats: A quantitative study
Authors: Sargolzaei-Aval Fereydoon , Saberi Eshagh Ali , Arab Mohammad Reza , Sargolzaei Narjes , Sanchooli Tayebeh , Tavakolinezhad Sima
Published: February 2020

Background.
Regeneration of bone defects remains a challenge for maxillofacial surgeons. The present study aimed to compare the effects of octacalcium phosphate (OCP) and the combination of octacalcium phosphate/gelatin (OCP/Gel) on mandibular bone regeneration in rats Methods. In the present study, 36 male Sprague-Dawley rats were used. The animals were randomly assigned to the following experimental groups: OCP (n=12), OCP/Gel (n=12), and the control group (n=12). Defects were created in the rat mandibles and filled with 10 mg of OCP and OCP/Gel disks in the experimental groups. In the control group, however, no substance was administered. Samples were taken on days 7, 14, 21 and 56, respectively, after the implantation. Sections (5 µ) were prepared and stained by H&E. The sections were studied, and the volume fraction of newly formed bone was measured by Dunnett's T3 test based on the significance level (P=0.05). Results. In the experimental groups, the new bone formation began from the margin of defects 7‒14 days after the implantation. During the healing process, the newly formed bone healed a larger area of the defects and grew structurally. In the control group, the defects were primarily filled with dense connective tissue, and only a small amount of new bone was formed. The present study showed a statistically significant difference in the volume of newly formed bone between the experimental groups and the control group (P<0.001). Conclusion. OCP/Gel composite can be beneficial in the healing process of mandibular bone defects.
Assessment of computer-controlled local anesthetic delivery system for pain control during restorative procedures: A randomized controlled trial
Authors: Saoji Hrishikesh , Thomas Nainan Mohan , Nanjappa Naveen , Khairnar Mahesh Ravindra , Hishikar Meeta , Jadhav Vivek
Published: February 2020

Background.
Local anesthesia is given to decrease pain perception during dental treatments, but it may itself be a reason for pain and aggravate the dental fear. Computer-controlled local anesthetic delivery system (CCLADS) is one of the alternatives for decreasing the patients’ pain during local anesthesia. This study compared the time required for the recovery from anesthesia, pain/discomfort during injection and pain/discomfort 24 hours after administering local anesthesia with CCLADS, a standard self-aspirating syringe and a conventional disposable 2-mL syringe. Methods. The study was conducted on 90 subjects (an age group of 20-40 years), who suffered from sensitivity during cavity preparation. They were randomly divided into three groups of 30 individuals each to receive intraligamentary anesthesia (2% lignocaine with 1:80,000 adrenaline) using either of the three techniques: CCLADS, a standard self-aspirating syringe, or a conventional disposable 2-mL syringe. The onset of anesthesia, time required for recovery from anesthesia (in minutes), pain/discomfort during injection and pain/discomfort 24 hours after administering local anesthesia were recorded. Results. The time required for the onset of anesthesia and recovery from anesthesia was shorter with CCLADS (4.83±2.31 and 34.2±1.895, respectively) as compared to the standard self-aspirating group (10.83±1.90 and 43.5±7.581, respectively) and the conventional group (11.00±2.03 and 43.5±6.453, respectively) (P<0.001). The patients in the CCLADS group experienced no pain during local anesthesia administration as compared to the patients in the self-aspirating and conventional groups. The CCLADS and self-aspirating groups showed lower pain response as compared to the conventional group for pain after 24 hours. Conclusion. CCLADS can be an effective and pain-free alternative to conventional local anesthetic procedures.
Anesthetic efficacy of articaine/epinephrine plus mannitol in comparison with articaine/epinephrine anesthesia for inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: A randomized controlled clinical trial
Authors: Shakoui Sahar , ghodrati mostafa , Ghasemi Negin , Pourlak Tannaz , Abdollahi Amir Ardalan
Published: February 2020

Background.
It is difficult to achieve successful pulpal anesthesia in mandibular posterior teeth with symptomatic irreversible pulpitis. The present study aimed to compare the effect of articaine/epinephrine anesthesia with articaine/epinephrine at a combination of 0.5 mol/mL of mannitol for the inferior alveolar nerve block (IANB) in patients presenting with symptomatic irreversible pulpitis in the mandibular first molar tooth. Methods. One hundred patients with symptomatic irreversible pulpitis in the mandibular first molar tooth were selected and randomly divided into two groups based on the injection method. The first group underwent an IANB technique with 1.8 mL of articaine, whereas the second group received 2.9 mL of a formulation, consisting of 1.8 mL of articaine plus 1.1 mL of 0.5 mol/L of mannitol. Fifteen minutes after injections and anesthesia of the lip, the access cavity was prepared. According to the visual analog scale (VAS) criteria, no pain or mild pain for caries removal, pulp exposure and canal instrumentation were regarded as success. Chi-squared test was used for the analysis of data. The level of significance was set at 0.05. Results. The success rate in the group with articaine/epinephrine anesthesia plus mannitol was higher than that in the group with articaine/epinephrine anesthesia, with no significant difference between the two groups (P>0.05). Conclusion. It was concluded, under the limitations of this study, that adding mannitol to articaine/epinephrine anesthesia did not increase the success of IANB in mandibular posterior teeth with symptomatic irreversible pulpitis.
Relationship between Microalbuminuria and Disease Activity in Patients with Ulcerative Colitis
Authors: Masnadi Shirazi Kourosh , Khayati Sima , Baradaran Binazir Maryam , Nikniaz Zeinab
Published: February 2020

BACKGROUND Introducing a non-invasive method for determining disease activity is important in patients with ulcerative colitis (UC). So in this study, we aimed to assess the association between disease activity index and microalbuminuria in patients with UC. METHODS In the present cross-sectional study, 84 patients with UC were selected. The disease activity was calculated by the partial Mayo clinic score. Microalbuminuria was assessed using the immunoturbidimetric method in a first-voided sample in the morning in two consecutive days and the mean of these two measurements was reported as urinary microalbumin level. Serum C reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fecal calprotectin were measured respectively using conventional turbidimetric immunoassay, Westergren method, and ELISA methods. RESULTS The mean age of the participants was 40.01 ± 12.85 years, 60.8% of them were female and 53.5% had microalbuminuria. The frequency of microalbuminuria was significantly higher in patients with active compared with inactive inflammatory bowel disease (IBD). There were significant differences between the patients with active and inactive disease regarding CRP, ESR, and calprotectin (p < 0.001). Moreover, there was a strong correlation between microalbuminuria and CRP (r = 0.89, p < 0.001), ESR (r = 0.92, p < 0.001), and calprotectin (r = 0.91, p < 0.001). CONCLUSION Microalbuminuria could be used as a non-invasive marker of disease activity in patients with UC.
Esophageal Ulcer Due to Ectopic Pancreatic Tissue: A Case Report
Authors: Alavinejad Pezhman , Sina Amir Hossein , Dehnavi Damoon , Nayebi Morteza
Published: February 2020

Heterotopic pancreatic tissue, known as pancreatic rest, is a pancreatic tissue that lacks anatomic and vascular continuity with the main body of the pancreas. Common locations for this tissue include the stomach, duodenum, jejunum, Meckel diverticulum, and ileum. In this report, we present a case of a patient whose pancreatic rest was diagnosed primarily during the investigation of dysphagia with solid foods and it was located in the mid esophagus as an unusual location.
Intraconal Metastasis Leading to Diagnosis of Hepatocellular Carcinoma
Authors: Madabhavi Irappa , KS Sandeep , Dharmarajan Lethika Rahul , Tumbal Satish , Miskin Arun T , Sarkar Malay , Modi Mitul
Published: February 2020

Hepatocellular carcinoma (HCC) is the commontumor of the liver and the third most common cause of cancer-related mortality worldwide. Patients with HCC may have metastasis to different sites. Intrahepatic and extrahepatic metastases are found in (~50–75%). Lung and regional lymph nodes are the most commonly involved sites. Metastasis to bone, skin, and adrenal glands are rare. Orbit metastasis and intracranial invasion are extremely rare. We are presenting a case of HCC that metastasized to the orbital cavity. The patient presented with progressive proptosis of the eyeball with retrobulbar and intracranial invasion and involvement of the sub-scalp region. Based on the imaging findings, it was initially misdiagnosed as meningioma; however, histopathological examination of the biopsy specimen resulted in a definitive diagnosis of HCC metastasis. The present case reveals that the alternative diagnosis of metastasis must be considered when diagnosing retrobulbar lesions in patients with HCC.
Further Evaluation of the Associations Between Psychopathic Traits and Symptoms of PTSD and Depression in a Nonclinical Sample
Authors: Kavish Nicholas , Boisvert Danielle , Cooke Eric M. , Lewis Richard H. , Woeckener Matthias , Wells Jessica , Armstrong Todd A.
Published: February 2020

Examining psychopathic traits at the factor or facet level has revealed that various aspects of psychopathy may be differentially related, even in opposing directions, to important outcomes (e.g., intelligence, emotion regulation). Empirical work on relations between psychopathy and internalizing disorders, such as posttraumatic stress disorder (PTSD) and depression, has provided evidence for a positive association with antisocial traits. However, findings for the affective domain have been more equivocal. The current study (N = 732) sought to replicate past findings of the positive association of antisocial psychopathic traits with higher levels of PTSD and depressive symptoms, and to further explore associations between affective traits of psychopathy and these disorders using two measures of psychopathy. Results confirmed prior findings of a positive correlation between antisocial features and self-reported PTSD/Depression symptom severity, but they did not provide evidence for any association with affective traits. Future research using longitudinal designs is needed to begin establishing temporal ordering of the psychopathy–internalizing relationship.
Functional Clusters of Neurons in Layer 6 of Macaque V1
Authors: Hawken Michael J. , Shapley Robert M. , Disney Anita A. , Garcia-Marin Virginia , Henrie Andrew , Henry Christopher A. , Johnson Elizabeth N. , Joshi Siddhartha , Kelly Jenna G. , Ringach Dario L. , Xing Dajun
Published: February 2020

Layer 6 appears to perform a very important role in the function of macaque primary visual cortex, V1, but not enough is understood about the functional characteristics of neurons in the layer 6 population. It is unclear to what extent the population is homogeneous with respect to their visual properties or if one can identify distinct subpopulations. Here we performed a cluster analysis based on measurements of the responses of single neurons in layer 6 of primary visual cortex in male macaque monkeys (Macaca fascicularis) to achromatic grating stimuli that varied in orientation, direction of motion, spatial and temporal frequency, and contrast. The visual stimuli were presented in a stimulus window that was also varied in size. Using the responses to parametric variation in these stimulus variables, we extracted a number of tuning response measures and used them in the cluster analysis. Six main clusters emerged along with some smaller clusters. Additionally, we asked whether parameter distributions from each of the clusters were statistically different. There were clear separations of parameters between some of the clusters, particularly for f1/f0 ratio, direction selectivity, and temporal frequency bandwidth, but other dimensions also showed differences between clusters. Our data suggest that in layer 6 there are multiple parallel circuits that provide information about different aspects of the visual stimulus.

SIGNIFICANCE STATEMENTThe cortex is multilayered and is involved in many high-level computations. In the current study, we have asked whether there are subpopulations of neurons, clusters, in layer 6 of cortex with different functional tuning properties that provide information about different aspects of the visual image. We identified six major functional clusters within layer 6. These findings show that there is much more complexity to the circuits in cortex than previously demonstrated and open up a new avenue for experimental investigation within layers of other cortical areas and for the elaboration of models of circuit function that incorporate many parallel pathways with different functional roles.
Colocalized White Matter Plasticity and Increased Cerebral Blood Flow Mediate the Beneficial Effect of Cardiovascular Exercise on Long-Term Motor Learning
Authors: Lehmann Nico , Villringer Arno , Taubert Marco
Published: February 2020

Cardiovascular exercise (CE) is a promising intervention strategy to facilitate cognition and motor learning in healthy and diseased populations of all ages. CE elevates humoral parameters, such as growth factors, and stimulates brain changes potentially relevant for learning and behavioral adaptations. However, the causal relationship between CE-induced brain changes and human's ability to learn remains unclear. We tested the hypothesis that CE elicits a positive effect on learning via alterations in brain structure (morphological changes of gray and white matter) and function (functional connectivity and cerebral blood flow in resting state). We conducted a randomized controlled trial with healthy male and female human participants to compare the effects of a 2 week CE intervention against a non-CE control group on subsequent learning of a challenging new motor task (dynamic balancing; DBT) over 6 consecutive weeks. We used multimodal neuroimaging [T1-weighted magnetic resonance imaging (MRI), diffusion-weighted MRI, perfusion-weighted MRI, and resting state functional MRI] to investigate the neural mechanisms mediating between CE and learning. As expected, subjects receiving CE subsequently learned the DBT at a higher rate. Using a modified nonparametric combination approach along with multiple mediator analysis, we show that this learning boost was conveyed by CE-induced increases in cerebral blood flow in frontal brain regions and changes in white matter microstructure in frontotemporal fiber tracts. Our study revealed neural mechanisms for the CE–learning link within the brain, probably allowing for a higher flexibility to adapt to highly novel environmental stimuli, such as learning a complex task.

SIGNIFICANCE STATEMENTIt is established that cardiovascular exercise (CE) is an effective approach to promote learning and memory, yet little is known about the underlying neural transfer mechanisms through which CE acts on learning. We provide evidence that CE facilitates learning in human participants via plasticity in prefrontal white matter tracts and a colocalized increase in cerebral blood flow. Our findings are among the first to demonstrate a transfer potential of experience-induced brain plasticity. In addition to practical implications for health professionals and coaches, our work paves the way for future studies investigating effects of CE in patients suffering from prefrontal hypoperfusion or white matter diseases.
Criminal Justice as Regulation
Authors: Feeley Malcolm M.
Published: February 2020

Problem-solving courts and restorative justice programs provide important new alternatives to cope with recurring problems in the criminal justice process. But they are much more. They are harbingers of a new theory of the criminal justice process that challenges traditional accounts in fundamental ways. Although practices akin to problem-solving courts and restorative justice have long operated outside or below the radar of the theory of criminal law and the adjudicative process, over the past few decades these practices have come to the fore and are now supported with full-blown theories, which threaten to displace traditional accounts of criminal responsibility, criminal liability, and indeed the core features of the criminal justice process. The new theories are based on theories of regulation, where the objective is not so much to enforce the law as it is to secure compliance to the law in order to facilitate harm reduction and restore social order. Nowhere is this new development so clearly seen as in the opening chapters of John Braithwaite’s important book, Restorative Justice and Responsive Regulation. In this book, Braithwaite offers a full-throated theory of the new criminal justice process that is based on recent developments in regulatory theory and, most particularly, responsive regulation, which Braithwaite helped to develop. This model is implicit to varying degrees in any number of recent developments in the criminal justice process, and in this paper, I argue it has the potential for displacing the classical theory of criminal law.
The Right to Reintegration
Authors: Yankah Ekow N.
Published: February 2020

“Western” democracies take an uneven view of the state’s role in reintegrating the incarcerated following punishment. Particularly in the United States, where retributivism remains punishment’s dominant justification, questions of punishment center on how wrongdoers ought to suffer for transgressions. Thus, reintegrative programs are viewed as a question of policy preference for various jurisdictions, and a question of grace for the state. A republican political theory, centered on our civic bonds, emphasizes different commitments. On this view, punishment is justified where a citizen attacks another in ways that deny their civic equality and undermine our ability to maintain a common civic life. But the same justification that requires protecting civic equality through punishment compels the state to reintegrate offenders after punishment; the right to punish and the obligation to reintegrate are complementary political duties. As such, reintegrative policies are not merely the state’s choice but rather a state duty and an offender’s right. This article explores the obligations the state owes ex-felons in reintegrating them into civic society across a range of political and civic rights. It also addresses reintegration’s important role in ameliorating the racial scars of American criminal punishment.
Custos com Internações por Condições Sensíveis à Atenção Primária: séries temporais 2008-2015
Authors: Sousa Maria Evely Ferreira de , Sousa Eduardo Carvalho de , Melo Geórgia Alcântara Alencar , Carvalho Rhanna Emanuela Fontenelle Lima de , Silva Maria Rocineide Ferreira da , Pereira Francisco Gilberto Fernandes
Published: February 2020

Objetivo: avaliar os custos com Internações por Condições Sensíveis à Atenção Primária, ponderando as séries temporais de 2008-2015. Métodos: estudo ecológico que se utilizou dos registros do Sistema de Informação Hospitalar. Amostra composta pelos registros de internações de diagnósticos incluídos na Lista Brasileira de Internações por Condições Sensíveis à Atenção Primária. Regressões polinomiais foram utilizadas para análise da tendência temporal das taxas ao longo do período. Resultados: houve decréscimo nas taxas por 10.000 habitantes (67.38 a 51.99) (r2=0,9783; p<0,001). As causas mais onerosas foram: asma, insuficiência cardíaca, cistite e pneumonia. Evidenciou-se tendência de redução das internações (β=-2,15; p<0,001) e dispêndios médios (β=-2243,24; p=0,169). Conclusão: o diagnóstico asma obteve maior consumo, enquanto que a doença inflamatória do colo do útero atingiu menor quantitativo. Na série temporal, observou-se tendência de redução de gastos evidenciada pela diferença entre o maior custo no ano de 2009 e o menor, em 2015.
Perfil clínico-epidemiológico de pacientes cirúrgicos com ressecamento ocular e risco de ressecamento ocular
Authors: Medeiros Raianny Alves Costa , Araújo Jéssica Naiara de Medeiros , Soares Raffaela Patricia da Silva , Silva Amanda Barbosa da , Ferreira Júnior Marcos Antonio , Vitor Allyne Fortes
Published: February 2020

Objetivo: determinar o perfil clínico-epidemiológico de pacientes cirúrgicos com ressecamento ocular e com o diagnóstico de enfermagem Risco de ressecamento ocular, no período pós-operatório. Métodos: estudo transversal, com 82 pacientes em pós-operatório. Para análise, utilizaram-se as frequências, medidas do centro de distribuição e respectivas variabilidades. Resultados: prevalência equivalente entre o ressecamento ocular e o diagnóstico de enfermagem. A média de idade foi 57,7 anos para pacientes com ressecamento ocular e 59,6 anos para aqueles com o diagnóstico de risco. Em ambos os grupos, existiu predominância do sexo feminino, cirurgias cardiovasculares e uso de anestésico geral. O tempo de procedimento cirúrgico obteve mediana de 105 minutos para pacientes com ressecamento ocular e 67,5 minutos para aqueles com o diagnóstico de risco. Conclusão: predominância de mulheres em meia idade submetidas a cirurgias eletivas de motivos cardiovasculares para ambos os grupos, entretanto, com tempo de procedimento cirúrgico distinto.
Mindfulness affects stress, ghrelin, and BMI of obese children: a clinical trial
Authors: López-Alarcón Mardia , Zurita-Cruz Jessie N , Torres-Rodríguez Alonso , Bedia-Mejía Karla , Pérez-Güemez Manuel , Jaramillo-Villanueva Leonel , Rendón-Macías Mario E , Fernández Jose R , Martínez-Maroñas Patricia
Published: February 2020

Childhood obesity is associated with stress. However, most treatment strategies include only dietary and physical activity approaches. Mindfulness may assist in weight reduction, but its effectiveness is unclear. We assessed the effect of mindfulness on stress, appetite regulators, and weight of children with obesity and anxiety. A clinical study was conducted in a pediatric hospital. Eligible children were 10–14 years old, BMI ≥95th percentile, Spence anxiety score ≥55, and who were not taking any medication or supplementation. Participants were assigned to receive an 8-week conventional nutritional intervention (CNI) or an 8-week mindfulness-based intervention plus CNI (MND-CNI). Anthropometry, body composition, leptin, insulin, ghrelin, cortisol, and Spence scores were measured at baseline and at the end of the intervention. Anthropometry was analyzed again 8 weeks after concluding interventions. Log-transformed and delta values were calculated for analysis. Thirty-three MND-CNI and 12 CNI children finished interventions; 17 MND-CNI children accomplished 16 weeks. At the end of the intervention, significant reductions in anxiety score (−6.21 ± 1.10), BMI (−0.45 ± 1.2 kg/m2), body fat (−1.28 ± 0.25%), ghrelin (−0.71 ± 0.37 pg/mL), and serum cortisol (−1.42 ± 0.94 µg/dL) were observed in MND-CNI children. Changes in anxiety score, ghrelin, and cortisol were different between groups (P < 0.05). Children who completed 16 weeks decreased BMI after intervention (−0.944 ± 0.20 kg/m2, P < 0.001) and remained lower 8 weeks later (−0.706 ± 0.19 kg/m2, P = 0.001). We concluded that mindfulness is a promising tool as an adjunctive therapy for childhood obesity. However, our findings need confirmation in a larger sample population.
Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism: analysis of surgical outcome
Authors: Kobayashi Hiroki , Nakamura Yoshihiro , Abe Masanori , Kurihara Isao , Itoh Hiroshi , Ichijo Takamasa , Takeda Yoshiyu , Yoneda Takashi , Katabami Takuyuki , Tsuiki Mika , Wada Norio , Ogawa Yoshihiro , Sakamoto Ryuichi , Kawashima Junji , Sone Masakatsu , Inagaki Nobuya , Yoshimoto Takanobu , Yamada Tetsuya , Okamoto Ryuji , Matsuda Yuichi , Fujita Megumi , Watanabe Minemori , Tamura Kouichi , Tanabe Akiyo , Naruse Mitsuhide , _ _
Published: February 2020

Objectives

We investigated the clinical significance of ACTH stimulation during adrenal venous sampling (AVS) by surgical outcome of primary aldosteronism (PA).

Design

Multicenter retrospective study by Japan PA study.

Method

We allocated 314 patients with both basal and ACTH-stimulated AVS data who underwent adrenalectomy to three groups: basal lateralization index (LI) ≥2 with ACTH-stimulated LI ≥4 on the ipsilateral side (Unilateral (U) to U group, n = 245); basal LI <2 with ACTH-stimulated LI ≥4 (Bilateral (B) to U group, n = 15); and basal LI ≥2 with ACTH-stimulated LI <4 (U to B group, n = 54). We compared surgical outcomes among the groups using the Primary Aldosteronism Surgical Outcome (PASO) criteria.

Results

Compared with U to U group, U to B group had poor clinical and biochemical outcomes and low rates of adrenal adenoma as pathological findings (P = 0.044, 0.006, and 0.048, respectively), although there were no significant differences between U to U and B to U groups. All patients in U to B group with clinical and biochemical benefits, however, had adrenal adenoma as pathological findings and could be well differentiated from those with poor surgical outcomes via basal LI (>8.3), but not ACTH-stimulated LI. These results were similar even when we defined each group based on a cut-off value of 4 for basal LI.

Conclusions

Although PA patients in U to B group had worse surgical outcomes than did those in U to U group, basal LI could discriminate among patients with better surgical outcomes in U to B group.
Abiraterone acetate treatment lowers 11-oxygenated androgens
Authors: Wright Connor , O’Day Patrick , Alyamani Mohammed , Sharifi Nima , Auchus Richard J
Published: February 2020

Context

The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone, derived from the prodrug abiraterone acetate (AA), inhibits the activity of cytochrome P450 17-hydroxylase/17,20-lyase (CYP17A1), the enzyme required for all androgen biosynthesis. AA treatment effectively lowers testosterone and androstenedione in 21OHD and CRPC patients. The 11-oxygenated androgens are major adrenal-derived androgens, yet little is known regarding the effects of AA administration on 11-oxygenated androgens.

Objective

To test the hypothesis that AA therapy decreases 11-oxygenated androgens.

Design

Samples were obtained from 21OHD or CRPC participants in AA or AA plus prednisone (AAP)-treatment studies, respectively.

Methods

We employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure the 11-oxygenated androgens, 11β-hydroxyandrostenedione, 11-ketoandrostenedione, 11β-hydroxytestosterone, and 11-ketotestosterone, in plasma or serum samples from six 21OHD and six CRPC patients before and after treatment with AA or AAP, respectively.

Results

In CRPC patients, administration of AAP (1000 mg/day AA with prednisone and medical castration) lowered all four 11-oxygenated androgens to below the lower limits of quantitation (<0.1–0.3 nmol/L), equivalent to 64–94% reductions from baseline. In 21OHD patients, administration of AA (100–250 mg/day for 6 days) reduced all 11-oxygenated androgens by on average 56–77% from baseline.

Conclusions

We conclude that AA and AAP therapies markedly reduce the production of the adrenal-derived 11-oxygenated androgens, both in patients with high (21OHD) or normal (CRPC) 11-oxygenated androgens at baseline, respectively. Reduction of 11-oxygenated androgens is an important aspect of AA and AAP pharmacology.
miR-98 is involved in missed abortion by targeting GDF6 and FAPP2
Authors: Zhu Qi , Dong Yi-Chao , Zhang Lu , Ma Xu , Xia Hong-Fei
Published: February 2020

Missed abortion (MA) is a common disease in obstetrics and gynecology. More and more studies have focused on the relationship between miRNAs and pregnancy maintenance and its related diseases. The aim of this article is to explore the relationship between miRNA and MA. The expression of miR-98 were detected by in situ hybridization and real-time PCR. Cell proliferation, activity and migration were measured via Edu, MTT, and transwell assays. The target genes of miR-98 are identified by dual-luciferase activity assay. And the expression levels of target genes were determined by Western blot, real-time PCR and immunohistochemistry. miR-98 was significantly up-regulated in placental villi from over 35 years old MA patients compared with the age-matched normal pregnant women. Up-regulation of miR-98 suppressed the proliferation, activity and migration of the human trophoblast HTR-8/SVneo cell in vitro. miR-98 could bind to GDF6 and FAPP2 mRNA 3’-UTR and negatively regulate their expression. The downregulation of miR-98 promoted cell proliferation, then knockdown of GDF6 or FAPP2 inhibited miR-98-mediated cell proliferation. GDF6 and FAPP2 expression in the placental villi from MA patients were decreased compared to normal placental tissues. The expression of miR-98 in MA had an opposite relationship with the expression of GDF6 and FAPP2. Overexpression of miR-98 is associated with the occurrence of MA. miR-98 prevents proliferation, viability and migration of trophoblast cells partially through targeting GDF6 and FAPP2.
Transseptal Approach for Mitral Valve Replacement in Dextrocardia with Situs Inversus Totalis: A Case Report and Review of the Literature
Authors: Stiru Ovidiu , Geana Roxana Carmen , Ilie Razvan Radu , Chioncel Ovidiu , Tulin Raluca , Valeanu Liana , Bubenek Serban , Filipescu Daniela , Iliescu Vlad Anton
Published: February 2020

We consider mitral valve disease requiring surgery in a patient with dextrocardia and situs inversus totalis to be an exceptional finding. The transseptal approach for mitral valve surgery in dextrocardia represents a technical challenge owing to its anatomic particulars. We present the case of a 56-year-old female patient who had been diagnosed with situs inversus totalis in childhood and with chronic atrial fibrillation in adulthood and was under oral anticoagulant treatment. She was referred to our hospital for increasing dyspnea and palpitation. Transthoracic echocardiography detected severe mitral regurgitation associated with moderate tricuspid regurgitation, with normal left and right ventricular function. Contrast chest computed tomography (CT) and preoperative abdominal CT showed both dextrocardia and situs inversus totalis, with normal continuity of the inferior vena cava. Biatrial cannulation was performed with the surgeon standing on the right side of the patient, and mitral valve replacement using a transseptal approach was performed with the surgeon standing on the left side of the patient. In this case report, we emphasize the rarity of mitral valve disease in a patient with dextrocardia and the inherent potential difficulty that can appear in this particular anatomic condition.
The Possibilities for Genealogy and Local History Research in the Panevėžys Region
Authors: Bagdonas Vytenis
Published: February 2020

The article explores the surviving genealogical information resources of Panevėžys churches – christening, marriages, deaths, and population censuses. On the basis of the data provided in these books, repeating common names in different areas of the Panevėžys are overviewed. The origin of family names and their territorial linkage are suggested. Published ethnographic books are featured to reflect the availability of the genealogical research in Panevėžys vicinity. Relevant name correlations are drawn using Lithuanian State documents, such as the archives of the nobility. A new study of genetic genealogy is introduced, its value to research, and a spectrum of open possibilities it offers for solving otherwise complex kin puzzles. With good judgement and analysis, the reader may find the approach taken here encouraging to further explore the expatriates and peoples with relation of Lithuanian ancestry of the 19th–20th c.
The Cards of Internal Passports of the Population of Kaunas City of the 1920–1940s as a Source of Genealogy and Local History
Authors: Balkus Mindaugas
Published: February 2020

This article analyzes the cards of internal passports issued in Kaunas city in 1920–1940 and the sociodemographic data of the population (nationality, confession, place of birth, work activity, etc.) provided in them. Their significance for the researches of genealogy and local history is discussed. It was found that in 1920–1940, 89 620 people received internal passports in Kaunas, including 58.76% Lithuanians, 30.27% Jews, 3.16% Poles, 3.12% Germans, 2.74% Russians, 0.33% Belarusians; 59.13% of the persons who received internal passports in Kaunas were Catholics, 28.9% – Jews, 5.44% – Evangelical Lutherans and Evangelical Reformats, 3.14% – Orthodox, 0.96% – Old Believers. These results are in many cases close to the data of the 1923 general census of the Lithuanian population; 35.22% of the residents of Kaunas were born in this city, 11.4% – in Kaunas County, 6.86% – in then-Soviet Union’s territory, while the rest – in the different regions of Lithuania and abroad. According to the character of the working activity (occupation), Lithuanians were significantly dominant among the officials (90.94%), being farmers (88.05%), servants (82.84%), or workers (75.85%), while Jews were predominant among traders (83.2%).
Genealogical Researches of Karpiai Family: the Possibilities Evaluation of Prosopography Researches
Authors: Pangonytė Rugilė
Published: February 2020

Karpiai – a famous noble family of the Grand Duchy of Lithuania – are distinguished by their political and educative activities. The family’s influence is most markedly observed in the 18th–19th centuries, when the most famous and active members of the Karpiai family had lived. This family has not received plenty of scholarly attention, though from time to time new studies do spring up. Almost all of them are oriented to analyzing the activities of separate members of the Karpiai family, while the family’s origin and genealogy researches are scarce. Recently, prosopography has been found to be a very promising method for analyzing noble families. It analyzes the person, their environment, social position, career, power amassment, political influence, and other factors, researching bonds between individuals and constantly evaluating them in an interplay aspect. Besides, in prospect, a prosopographic analysis creates an ideal base for a person’s historical biographical research. This article returns to the beginning of the Karpiai family, studies the theories regarding its legendary origin and the appearance of their progenitor’s in the Grand Duchy, and explains how the recent researches of the Karpiai family’s origin lay the foundation for productive prosopographic researches. Since in prosopography one of the most important methods is the genealogical one, this article discusses the topic of genealogical tree researches of the Karpiai family.
Transanal Total Mesorectal Excision (TaTME): Experience in Klaipėda University Hospital
Authors: Klimašauskienė Vita , Samalavičius Narimantas Evaldas
Published: February 2020

Introduction. Colorectal cancer ranks third on the list of the most common cancers. In 1979 R. J. Heald described total mesorectam excision (TME) which became a gold standard for rectal cancer treatment. This operation is performed all over the world open, laparoscopic and robotic. Operating on low and very low rectal cancer, distal bowel mobilisation if often the most difficult part of the operation. Aa a solution to this problem transanal abdominotransanal rectal resection (TATA) and transanal total mesorectal excision (TaTME) were proposed. This article reviews the experience and short-term postoperative outcomes of TaTME performed in Klaipėda University Hospital.Methods. The first stage of surgery was performed with patient placed in the prone jackknife (Kraske) position. Using electrocauthery circular mobilisation of the rectum was performed starting at least 1 cm from the lower edge of the tumour. Up to 10 cm of the rectum was mobilised from below. The second stage was performed with patient in lithotomy position. Laparoscopic TME was performed. For 11 (78.57%) patients hand sown anastomosis was performed and for 1 (7.17%) patient stapler was used. 2 (14.28%) patients underwent the Hartmann’s procedure.Results. In period 2018.03–2019.10 TaTME was performed for 14 patients. The medium tumour high counting from dentate line was 2.54 (±1.28). 13 out of 14 patients were operated from 8 to 12 weeks after chemoradiotherapy. All (100%) rectal resections were radical (R0). On average 11.43 (±3.78) lymphnodes were harvested. 5 (35.71%) patients had complications after surgery.Conclusions. TaTME performed at Klaipėda University Hospital is effective operation for rectal cancer treatment.
Percutaneous Cholecystostomy is a Reasonable Alternative for the Treatment of Acute Cholecystitis in Critically Ill Patients: a Single Center Analysis
Authors: Ignatavicius Povilas , Kiudelis Mindaugas , Dekeryte Inga , Mikuckyte Deimante , Sasnauskaite Jolita , Lukasevic Karina , Barauskas Giedrius
Published: February 2020

Background / objective. Laparoscopic cholecystectomy is a safe procedure and the treatment of choice for acute cholecystitis. As an alternative treatment option in critically ill patients percutaneous cholecystostomy (PC) is performed.Methods. Retrospective review of patients who had undergone PC from 2008 to 2017 at the Department of Surgery, Hospital of Lithuanian University of Health Sciences Kaunas Clinics. Patients were reviewed for demographic features, laboratory tests, ASA class, complications, outcomes, hospital stay and mortality rate.Results. Fifty-four patients were included in the study. Forty patients (74%) were ASA III and ten patients (18.5%) – ASA IV. Statistically signi­ficant decrease in white blood cell count (from 14.26±6.61 to 8.65±5.15) and C-reactive protein level (from 226.22±106.60 to 51.91±63.70) following PC was observed. The median hospital stay was 13.06 (range 2–68) days and 30-day mortality rate 13%. There were no deaths directly related to procedure. For eleven patients (20.4%) delayed cholecystectomy was scheduled.Conclusions. PC is a reasonable treatment option for high-risk patients with acute cholecystitis and co-morbidities. It can be used as a temporizing treatment option or as a definitive treatment with a low number of delayed cholecystectomies.