bluuebunny/crossref_metadata_2025 huggingface dataset:
Ceramic veneers failure: a repair and reintervention clinical report
Authors: Gustavo F. B. Souza  , Verônica P. Lima  , Rafael R. Moraes  , Giana S. Lima
Published: June 2024

Introduction and Objective: Although the use of ceramic veneers is widespread, their failures are seldom reported. When fractures do occur, they are often related to treatment planning. This case report describes a 6.5-year follow-up of a restorative treatment involving ceramic laminate veneers on a patient with a nail-biting habit. Case report: After two restorations failed, repair with composite resin was chosen as an intermediary treatment, and the clinical steps until the ultimate replacement of the ceramics are described. Results and Conclusion: The repair resulted in postponing the restorations replacement for almost five years. It highlights that replacement does not need to be the first treatment option in cases of failures of feldspar ceramic laminate veneers. These failures may be managed conservatively with a composite resin repair, with the advantage of postponing the need for replacement.
Muscle-derived Stem Cell Exosomes Enhance Autophagy through the Regulation of the mTOR Signaling Pathway to Attenuate Glucolipotoxicity-induced Pancreatic Β-cell Injury
Authors: Zeng Xiang-Yu , Liu Zi-Wen , Li Hao-Ze , Liu Jian-Yu
Published: June 2024

Background:

Diabetes mellitus (DM) refers to a series of metabolic disorders, including
elevated blood glucose level diseases due to insufficient insulin secretion or insulin resistance.

Objective:

To investigate the effect and protective mechanism of muscle-derived stem cell exosomes
(MDSC-Exo) on glucolipotoxicity-induced pancreatic β cell injury.

Methods:

Primary rat muscle-derived stem cells (MDSCs) were isolated and cultured. After the
completion of the third-generation culture for MDSCs, MDSC-Exo was isolated. Then, the morphology
and diameter of exosomes were observed by means of electron microscopy and nanoparticle
tracking analysis (NTA) instrument. The expression of exosome-related proteins CD63, TSG101
and Calnexin was detected by western blot. After stimulation of rat insulinoma cell line INS-
1 with high glucose/palmitic acid (HG/PA) and/or MDSC-Exo, cell viability and apoptosis
were measured through MTT and flow cytometry (FCT), respectively. Biochemical reagents were
utilized for the examination of the levels of superoxide dismutase (SOD) and malondialdehyde
(MDA); enzyme-linked immunosorbent assay (ELISA) for the levels of cellular insulin secretion,
and the western blot for the expression level of LC3, p62, AKT, p-AKT, mTOR and p-mTOR.

Results:

MDSC-Exo was successfully isolated and identified, and it was found that MDSC-Exo
could reduce HG/PA-induced apoptosis as well as MDA levels in INS-1 cells. Also, MDSC-Exo
could significantly increase cell viability, insulin secretion ability within 24 hours and SOD level.
Besides, MDSC-Exo was able to significantly increase the LC3-II/I ratio, decrease the expression
level of p62, and promote autophagy in the cells. Aside from what has been mentioned, MDSC-
Exo showed a significant reduction effect on p-Akt and p-mTOR level as well as p-Akt/Akt
and p-mTOR/mTOR ratios.

Conclusion:

MDSC-Exo can alleviate oxidative stress and enhance autophagy by inhibiting Akt/
mTOR signaling pathway activation. Then, the inhibition of apoptosis and the promotion of insulin
secretion can be achieved to alleviate glucolipotoxicity-induced pancreatic β cell injury.
Analysis of Enhanced Wound Closure Potential of ADSC-Derived Secretome Compared to Aquacel Extra in Diabetic Rats
Authors: Bajuri Mohd Yazid , Rashidbenam Zahra , Mahidin Mohd Yusof , Law Jia Xian , Tan Geok Chin , Abdul Rani Rizal , Mohd Nor Fatimah , Imran Farrah Hani , Ng Min Hwei , Shafien Zikril Iman
Published: June 2024

Background:

Diabetes Mellitus (DM) can lead to serious complications, such as Diabetic
Foot Ulcers (DFUs). Currently, Aquacel Extra is one of the standard therapies for DFUs, but
its efficacy has some limitations that may be overcome by alternative treatments, such as the secretome
derived from Adipose-Derived Stem Cells (ADSCs). ADSC secretome has shown promising
results in promoting wound healing by enhancing cell proliferation, collagen synthesis, and migration
of fibroblasts.

Aims:

This study aims to compare the effect of the adipose-derived stem cell (ADSC) secretome
to Aquacel Extra, a hydrofiber dressing containing gel-forming agents, on wound healing in a diabetic
rat model. Aquacel Extra has sodium carboxymethylcellulose fibers, which contribute to its
unique properties.

Objective:

The objective of this study is to compare the wound healing outcome of ADSC secretome
and Aquacel Extra in streptozotocin-induced diabetic rats.

Methods:

Sprague Dawley rats received a single intravenous administration of streptozotocin to
induce diabetes mellitus (DM). A full-thickness excisional circular wound was created at the dorsum
aspect of the rats two weeks after diabetic induction. Rats were randomly divided into two
groups: the Aquacel Extra group, which received the hydrofiber dressing Aquacel Extra containing
gel-forming agents, and the secretome group, which received the ADSC secretome on days 0,
3, and 7. The gross examination was performed on days 0, 3, 7, and 14. On day 14, the rats were
euthanized, and full-thickness skin biopsies of the wounds were taken for histological and immunohistochemical
analysis.

Results:

The secretome group demonstrated accelerated cutaneous wound healing compared to
the Aquacel Extra group, as indicated by faster wound closure (p < 0.05). Hematoxylin and eosin
staining revealed a thicker epidermal layer in the secretome group than in the Aquacel Extra
group (p < 0.05). The mean histological score of the secretome group was higher at 10 ± 1.73 compared
to the score of 8.33 ± 1.52 in the Aquacel Extra group, indicating a more mature tissue architecture.
Immunohistochemical analysis showed lower expression of α-smooth muscle actin (α-sma)
in the secretome group than in the Aquacel Extra group, which correlated with reduced collagen
secretion and deposition in the secretome group, as indicated by Masson’s trichrome staining.

Conclusion:

The ADSC secretome accelerated the healing of diabetic wounds compared to Aquacel
Extra. However, as this study is preliminary, future studies should be conducted similar to this
study with a larger sample and wound size. In addition, the optimal dosage of ADSC secretome
and the components of the secretome that promoted wound healing should be determined to fully
elucidate the clinical potential of ADSC secretome.
Modulating Proliferation, Migration and Differentiation of Mesenchymal
Stem Cells Using Interleukins
Authors: Srinivasan Sankaranarayanan , Ghone Nalinkanth V.
Published: June 2024

Mesenchymal Stem Cells (MSCs) are multipotent stem cells that are obtained from
various tissue sources such as bone marrow, adipose tissues, umbilical cords, dental pulps, and peripheral
blood has high regenerative potential, migratory abilities, and immunosuppressive properties.
These properties make them attractive candidates for tissue engineering, immunosuppressive
therapies, and in vivo drug deliveries. MSCs, because of their high propensity to home in an injured
tissue microenvironment, are exposed to various cytokines. These cytokines modulate the activity
of MSCs to help in the regeneration of injured tissue. Interleukins are one such cytokine that
is present in injured tissue microenvironment and plays significant roles in the activation, differentiation,
proliferation, maturation, migration, and adhesion of not only immune cells but also
MSCs. Interleukins, through both autocrine and paracrine signaling mechanisms, modulate the
functioning of MSCs. This article reviews how interleukins influence MSCs by discussing their
signaling pathways, their effect on differentiation and other biological effects. A comprehensive
understanding of the influence of interleukins on MSCs may provide insights to manipulate improving
the therapeutic potential of MSCs or reducing potential risks such as undesirable immune
response and tumor formation.
Comparison of Factors Affecting the Immune Response to Hepatitis B Vaccination in Patients with Stage 5 Chronic Kidney Disease-haemodialysis and Predialysis
Authors: Light Casey , Heslop Karen , Kulkarni Hemant
Published: June 2024

Aim

To evaluate the factors that affect the immune response to Hepatitis B vaccination in the Stage 5 chronic kidney disease population (Haemodialysis and Predialysis).

Methods

Eligible Stage 5 chronic kidney disease patients on haemodialysis (Cohort A: N= 39) and Predialysis (Cohort B: N=56) in an outer metropolitan renal service in Western Australia with no prior Hepatitis B infection or vaccination between Jan 2015 to Dec 2021 were involved in this retrospective cohort study.

Serological response to Hepatitis B vaccination (H-B-VAX II 40 mcg intramuscularly at 0, 1 and 6 months) was evaluated six-eight weeks post-vaccination. Factors such as age, gender, diabetes mellites, cardiovascular disease, hypertension, chronic obstructive airway disease, serum albumin, and erythropoietin stimulating agent dependence were studied for their influence on immune responses in these cohorts.

Results

There were 95 eligible respondents in the study. Cohort B (Predialysis) showed a significantly higher response than Cohort A (Haemodialysis) (66.1% vs 53.8%) (p=0.003). Different factors affecting the vaccine response were identified in the two cohorts. Serum albumin <35g/L was associated with negative response in 61.1% (p =0.0023)Cohort A HD patients. In the Predialysis Cohort B, 84.2%(p=0.026) were male gender, 63.2%(p=0.028) with the presence of cardiovascular disease, and 57.9%(p=0.001) who were Erythropoietin dependent showed a negative response to the vaccine.

Conclusion

This study showed that the Hepatitis B vaccine response was lower in HD patients than in Predialysis patients with stage 5 chronic kidney disease. Clinical factors of serum albumin, cardiovascular disease, and patient factors of gender and erythropoietin dependence were identified as factors that affected vaccine response in these two cohorts. We postulate these factors to be considered in the hepatitis B vaccination management to enhance immunological response strategies and extend to earlier stages of chronic kidney failure.
Analyzing Tribological and Mechanical Properties of Polymer
Nanocomposite for Brake Pad Applications - A Critical Review
Authors: Patel Yagnik , Joshi Unnati , Joshi Anand , Oza Ankit D. , Patel Vijay , Singh Laxman
Published: June 2024

A brake pad is an integral component of a vehicle's braking system, designed to impart
controlled friction and, ultimately, assist in slowing or stopping a vehicle. Their constituents include
binder, filler, abrasive, lubricant, and reinforcing fiber. Materials for brake pads must have
excellent wear resistance, increased heat dissipation, a consistent coefficient of friction, low
noise and vibration, durability, compatibility, minimal environmental impact, and cost-effectiveness.
This paper aims to examine the various materials used in brake pad applications. They are
composed of matrix, ceramic, and polymer composites, and are manufactured using various processes.
In addition to mechanical and tribological testing, there are various methods for testing
the mechanical and tribological properties of brake pads. Various instruments, such as SEM,
TEM, AFM, and XRD, were surveyed in order to analyse the morphology and crystal structure
of nanoscale brake pads. Various applications such as automobiles, railroads, and aerospace utilise
brake pads. The study reveals that integrating nano-fillers into polymer composites significantly
enhances the mechanical and tribological properties of automotive brake pads, offering a
promising route toward more durable, efficient, and safer braking systems. Through this analysis,
researchers will gain a deeper understanding of the materials used in brake pads and their adaptability
for various applications.
Identifying Cyber Threats in IoT based Connected Cars for Enhanced Security
Authors: Doraisamy Ainkaran , Abdul Rahman Nor Azlina , Harun Khalida Shajaratuddur
Published: June 2024

The Internet of Things (IoT) has garnered many ideas to create new IoT
products as well as enhance their existing products with the help of the internet. Tesla
is an example of an IoT device from the automotive industry. The most prominent
feature of the vehicle was the over-the-air (OTA) updates. A few vulnerabilities were
found in Tesla despite being one of the most secure vehicles in the world. The first
vulnerability was in the vehicle's key system, where radio signals from the key fob
were intercepted in a relay attack. The next vulnerability was due to the Tesla app,
where the hacker obtained the owner's login credentials. Besides, the infotainment
system of the vehicle also was compromised and hacked using a web browser bug
known as a JIT bug. Lastly, Tesla vehicles also had a vulnerability in their navigation
system too. This was demonstrated by a group of researchers who staged a GPS spoof
attack on Tesla model 3 while it was in Autopilot mode. Fake satellite coordinates were
transmitted by the researchers, who were then received by the GPS receiver. This
caused the vehicle to decelerate and made an emergency turn-off at a narrow pit stop.
These vulnerabilities can be fixed by following safety measures to counter cyberattacks. More layers of security should be installed on the existing security system to
ensure the vehicle does not get exploited easily by hackers.
Malware Analysis and Malicious Activity Detection using Machine Learning
Authors: Chowdhury Muhammad Jawed , Juremi Julia , Naseri Maryam Var
Published: June 2024

Criminals are working day and night to get hold of the data. They are also
getting more intelligent and are also using AI-powered threats to exploit vulnerabilities
to perform an attack. Information security is at a higher risk, now more than ever. Due
to the popularity of internet usage by users, the IT infrastructure is prone to security
threats. The damage done by computer malware and viruses is known to cost billions of
US dollars. Hence, this paper reviews the ways of integrating technology such as
machine learning, neural networks, deep learning, etc. which can help to develop an
intelligent system to protect and prevent the IT infrastructure from security threats. The
authors proposed AIVA, a Machine learning (ML) based detection system which is
able to classify a suspicious object as “safe” or “dangerous”. AIVA is composed of
three core components: static analysis, machine learning, and malicious detection.
IoT Policy and Governance Reference Architecture: Integrity and Security of Information Across IoT Devices
Authors: Yew Yap Chi , Kamsin Intan Farahana , Zainal Nur Khairunnisha
Published: June 2024

The Internet of Things (IoT) technology has been applied to our daily life
infrastructure to make our lives easier and more comfortable. However, various
variations in the IoT reference architecture represent that the developers need to be
aware in order to implement the technology in a secure and accurate form. The
knowledge of these reference architectures is important as they provide the guidelines
for IoT developers and enterprises to develop high-quality IoT products. Requirements
such as security, data process, and privacy issues must always be concerned. The
reference architectures are used in the development of IoT products. This paper
discusses and explores IoT-related field topics ranging from IoT reference architecture
to policy to governance. Different kinds of variations in the reference architecture and
the IoT governance policy are discussed to ensure the integrity and security of
information transmitted across devices in the IoT ecosystem.
Genes de resistencia inducida en Pinus hartwegii (Pinaceae) en el centro de México
Authors: Heredia-Bobadilla Rosa Laura , Gutiérrez-González Guadalupe , Cibrián Tovar David , Endara Agramont Angel Rolando , Colín Ferreyra María del Carmen , Arzate Fernández Amaury Martín
Published: June 2024

Antecedentes y Objetivos: El pino de las alturas (Pinus hartwegii) es la especie de pino que se distribuye a mayor altitud en México, forma comunidades clímax entre 3700 y 4300 m s.n.m. Esta especie se encuentra amenazada por la tala ilegal y un incremento de parásitos como los descortezadores (Dendroctonus sp.) y muérdagos enanos (Arceuthobium sp.). Esto en parte provoca que las medidas de control y manejo se centren en la remoción de los árboles afectados, cuando en realidad puede tratarse de individuos con una carga genética muy valiosa. El objetivo de este estudio fue identificar y obtener secuencias de genes de defensa y/o resistencia en pinos atacados por estos parásitos. De acuerdo con la bibliografía consultada hasta la elaboración de este trabajo, no hay reportes de este tipo de secuencias para pinos mexicanos. Métodos: Se obtuvieron secuencias de genes de defensa y resistencia de coníferas filogenéticamente cercanas a P. hartwegii y a partir de estas se diseñaron oligonucleótidos, con los cuales se realizaron reacciones de PCR. Los productos obtenidos se secuenciaron y las secuencias obtenidas fueron analizadas para determinar si correspondían a genes de defensa y resistencia propias de esta especie de pino. Resultados clave: Se logró obtener cuatro secuencias de genes ligados a la defensa y resistencia en coníferas con un nivel de homología entre 93 y 100% con genes de resistencia de otras coníferas, de los géneros Picea, Pinus y Pseudotsuga. Se discute la posible función de estas secuencias en la defensa de Pinus hartwegii frente a parásitos como los descortezadores y los muérdagos enanos y se reportan sus claves de acceso en GenBank.Conclusiones: Las secuencias reportadas podrán ser utilizadas en estudios de expresión genética del pino de las alturas.
Media Big Scrap Book Untuk Meningkatkan Minat Membaca Anak Usia 5-6 Tahun
Authors: Veronica Nina , Saida Naili , Kurniawati Tri
Published: June 2024

Membaca pada usia 5-6 tahun sangat penting karena ini adalah tahap perkembangan kognitif yang kritis. Membiasakan anak-anak membaca sejak dini dapat membantu dalam mengembangkan keterampilan bahasa, membentuk imajinasi, meningkatkan keterampilan berpikir kritis, dan meningkatkan kemampuan akademik di masa depan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh media Big Scrap Book dalam meningkatkan minat membaca anak usia 5-6 tahun. Metode penelitian yang digunakan yaitu kuantitatif dengan jenis penelitian pre-eksperimental dengan desain penelitian one-group pre-test post-test design, pada penelitian ini hanya menggunakan kelas eksperimen saja berjumlah 14 anak. Penelitian ini melalui tiga tahapan yaitu pre-test, treatment, dan post-test. Teknik pengumpulan data pada penelitian ini yaitu menggunakan observasi, wawancara, dan dokumentasi. Analisis data menggunakan Uji Wilcoxon Match Pairs Test. Hasil analisis data yang diperoleh hasil Ho ditolak artinya terdapat pengaruh Media big Scrap Terhadap minat membaca anak usia 5-6 tahun. Peneliti dapat menyimpulkan bahwa terdapat pengaruh media Big Scrapbook untuk meningkatkan minat membaca anak usia 5-6 tahun. Rekomendasi penelitian selanjutnya untuk meneliti peran dari strategi yang digunakan di sekolah sehingga tidak hanya media yang dilakukan penelitian.
Digital transformation in Vietnam: A case study of Hanoi SMEs
Authors:   Faculty of Business Administration and Tourism, Hanoi University, Hanoi, Vietnam, Minh Luong Ngoc , Tan Nguyen Ngoc ,   Faculty of Business Administration and Tourism, Hanoi University, Hanoi, Vietnam, Toan Dinh Van ,   VNU Center for Education Accreditation (VNU-CEA), Hanoi, Vietnam, Thao Truong Duc ,   Faculty of E-Commerce and Digital Economy, Dai Nam University, Hanoi, Vietnam, Huyen Nguyen Thanh ,   Faculty of E-Commerce and Digital Economy, Dai Nam University, Hanoi, Vietnam, Hoài Nguyễn Thu ,   Faculty of Economics and Management, Thang Long University, Hoàng Mai, Vietnam
Published: June 2024

This research involved surveying 456 Small and Medium-sized Enterprises (SMEs) in Hanoi, Vietnam, to understand the factors that affect their digital transformation. After gathering the data, it was analyzed using advanced statistical methods, specifically Structural Equation Modeling (SEM), with the help of software tools like SPSS and AMOS. The findings revealed six key factors that play a significant role in the digital transformation of SMEs. These factors mostly impact the process indirectly by shaping the companies' intentions toward digital transformation, with a less direct influence on the transformation process itself.
Is Stimulant Treatment in Children and Adolescents with Mood Dysregulation Associated with Adverse Outcomes?
Authors: O'Connor Hannah , Biederman Joseph , DiSalvo Maura , Joshi Gagan , Faraone Stephen V. , Wozniak Janet
Published: June 2024

The aim of this paper is to examine effects of stimulant treatment in children and adolescents with high levels of emotional dysregulation in a psychiatric outpatient clinic. Subjects were referred children and adolescents 6-17 years of age who presented to a child psychiatric outpatient clinic between September 2016-November 2021 and received a prescription for a stimulant medication. Children were stratified into those with low and high levels of emotional dysregulation as defined by an aggregate T-score of <180 or ≥210 on the combined Attention Problems, Aggressive Behavior, and Anxious/Depressed subscales of the Child Behavior Checklist (CBCL; CBCL-AAA). We analyzed patient prescription, diagnosis, and hospital visit data extracted from the electronic medical record from any time prior to referral through three months after referral. Patients with higher CBCL-AAA scores at clinic intake had a significantly different medication and diagnosis profile and were more likely to have a higher dosage of stimulants than patients with lower scores. These patients also were more likely to receive an additional medication class during follow-up, which was driven by second-generation antipsychotics (SGAs). Emergency room visits and inpatient psychiatric admissions were rare but present only in the group with higher CBCL-AA scores. These results suggest that stimulant treatment affects youth with high versus low levels of emotional dysregulation adversely with a need for higher stimulant doses and treatment augmentation with SGAs. The CBCL may be a useful tool for identifying poor outcomes with stimulant treatment.
Data-Driven Identification of Potentially Successful Intervention Implementations Using 5 Years of Opioid Prescribing Data: Retrospective Database Study (Preprint)
Authors: Hopcroft Lisa EM , Curtis Helen J , Croker Richard , Pretis Felix , Inglesby Peter , Evans David , Bacon Sebastian , Goldacre Ben , Walker Alex J , MacKenna Brian
Published: June 2024

BACKGROUND

We have previously demonstrated that opioid prescribing increased by 127% between 1998 and 2016. New policies aimed at tackling this increasing trend have been recommended by public health bodies, and there is some evidence that progress is being made.

OBJECTIVE

We sought to extend our previous work and develop a data-driven approach to identify general practices and clinical commissioning groups (CCGs) whose prescribing data suggest that interventions to reduce the prescribing of opioids may have been successfully implemented.

METHODS

We analyzed 5 years of prescribing data (December 2014 to November 2019) for 3 opioid prescribing measures—total opioid prescribing as oral morphine equivalent per 1000 registered population, the number of high-dose opioids prescribed per 1000 registered population, and the number of high-dose opioids as a percentage of total opioids prescribed. Using a data-driven approach, we applied a modified version of our change detection Python library to identify reductions in these measures over time, which may be consistent with the successful implementation of an intervention to reduce opioid prescribing. This analysis was carried out for general practices and CCGs, and organizations were ranked according to the change in prescribing rate.

RESULTS

We identified a reduction in total opioid prescribing in 94 (49.2%) out of 191 CCGs, with a median reduction of 15.1 (IQR 11.8-18.7; range 9.0-32.8) in total oral morphine equivalence per 1000 patients. We present data for the 3 CCGs and practices demonstrating the biggest reduction in opioid prescribing for each of the 3 opioid prescribing measures. We observed a 40% proportional drop (8.9% absolute reduction) in the regular prescribing of high-dose opioids (measured as a percentage of regular opioids) in the highest-ranked CCG (North Tyneside); a 99% drop in this same measure was found in several practices (44%-95% absolute reduction). Decile plots demonstrate that CCGs exhibiting large reductions in opioid prescribing do so via slow and gradual reductions over a long period of time (typically over a period of 2 years); in contrast, practices exhibiting large reductions do so rapidly over a much shorter period of time.

CONCLUSIONS

By applying 1 of our existing analysis tools to a national data set, we were able to identify rapid and maintained changes in opioid prescribing within practices and CCGs and rank organizations by the magnitude of reduction. Highly ranked organizations are candidates for further qualitative research into intervention design and implementation.
Digital Lifestyle Interventions for Young People With Mental Illness: A Qualitative Study Among Mental Health Care Professionals (Preprint)
Authors: Sawyer Chelsea , Carney Rebekah , Hassan Lamiece , Bucci Sandra , Sainsbury John , Lovell Karina , Torous John , Firth Joseph
Published: June 2024

BACKGROUND

Given the physical health disparities associated with mental illness, targeted lifestyle interventions are required to reduce the risk of cardiometabolic disease. Integrating physical health early in mental health treatment among young people is essential for preventing physical comorbidities, reducing health disparities, managing medication side effects, and improving overall health outcomes. Digital technology is increasingly used to promote fitness, lifestyle, and physical health among the general population. However, using these interventions to promote physical health within mental health care requires a nuanced understanding of the factors that affect their adoption and implementation.

OBJECTIVE

Using a qualitative design, we explored the attitudes of mental health care professionals (MHCPs) toward digital technologies for physical health with the goal of illuminating the opportunities, development, and implementation of the effective use of digital tools for promoting healthier lifestyles in mental health care.

METHODS

Semistructured interviews were conducted with MHCPs (N=13) using reflexive thematic analysis to explore their experiences and perspectives on using digital health to promote physical health in youth mental health care settings.

RESULTS

Three overarching themes from the qualitative analysis are reported: (1) motivation will affect implementation, (2) patients’ readiness and capability, and (3) reallocation of staff roles and responsibilities. The subthemes within, and supporting quotes, are described.

CONCLUSIONS

The use of digital means presents many opportunities for improving the provision of physical health interventions in mental health care settings. However, given the limited experience of many MHCPs with these technologies, formal training and additional support may improve the likelihood of implementation. Factors such as patient symptomatology, safety, and access to technology, as well as the readiness, acceptability, and capability of both MHCPs and patients to engage with digital tools, must also be considered. In addition, the potential benefits of data integration must be carefully weighed against the associated risks.
Centering Digital Health Equity During Technology Innovation: Protocol for a Comprehensive Scoping Review of Evidence-Based Tools and Approaches (Preprint)
Authors: Burns Kara , Bloom Shoshana , Gilbert Cecily , Merner Bronwen , Kalla Mahima , Sheri Sreshta , Villanueva Cleva , Matenga Ikihele Amio , Nazer Lama , Sarmiento Raymond Francis , Stevens Lindsay , Blow Ngaree , Chapman Wendy
Published: June 2024

BACKGROUND

In the rush to develop health technologies for the COVID-19 pandemic, the unintended consequence of digital health inequity or the inability of priority communities to access, use, and receive equal benefits from digital health technologies was not well examined.

OBJECTIVE

This scoping review will examine tools and approaches that can be used during digital technology innovation to improve equitable inclusion of priority communities in the development of digital health technologies. The results from this study will provide actionable insights for professionals in health care, health informatics, digital health, and technology development to proactively center equity during innovation.

METHODS

Based on the Arksey and O’Malley framework, this scoping review will consider priority communities’ equitable involvement in digital technology innovation. Bibliographic databases in health, medicine, computing, and information sciences will be searched. Retrieved citations will be double screened against the inclusion and exclusion criteria using Covidence (Veritas Health Innovation). Data will be charted using a tailored extraction tool and mapped to a digital health innovation pathway defined by the Centre for eHealth Research roadmap for eHealth technologies. An accompanying narrative synthesis will describe the outcomes in relation to the review’s objectives.

RESULTS

This scoping review is currently in progress. The search of databases and other sources returned a total of 4868 records. After the initial screening of titles and abstracts, 426 studies are undergoing dual full-text review. We are aiming to complete the full-text review stage by May 30, 2024, data extraction in October 2024, and subsequent synthesis in December 2024. Funding was received on October 1, 2023, from the Centre for Health Equity Incubator Grant Scheme, University of Melbourne, Australia.

CONCLUSIONS

This paper will identify and recommend a series of validated tools and approaches that can be used by health care stakeholders and IT developers to produce equitable digital health technology across the Centre for eHealth Research roadmap. Identified evidence gaps, possible implications, and further research will be discussed.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/53855
The mChoice app: usability evaluation of a patient tool for PrEP adherence monitoring and sexual behaviors (Preprint)
Authors: Dos Santos Fabiana Cristina , Brin Maeve , Tanner Mary R , Galindo Carla A , Schnall Rebecca
Published: June 2024

BACKGROUND

Background: Mobile health (mHealth) applications (apps) provide easy and quick access for users to monitor their health-related activities. Features such as medication reminders help users adhere to their medication schedules and automatically record these actions, thereby helping track their overall health management. Due to insufficient mHealth tools tailored to Human Immunodeficiency Virus (HIV) preventive care for young men who have sex with men (MSM), our study evaluated the usability of the mChoice app, a tool designed to enhance pre-exposure prophylaxis (PrEP) adherence and promote sexual health (e.g., encouraging the use of condoms and being aware of the partner’s HIV status and PrEP use).

OBJECTIVE

To apply systematic usability evaluations to test the mChoice app and to refine the visualizations to better capture and display patient-reported health information.

METHODS

Methods: Usability testing involved heuristic evaluations conducted with five experts in informatics and user testing with twenty young MSM who were taking or eligible to take PrEP.

RESULTS

Results: Participants demonstrated satisfaction with the appearance of the mChoice app, reporting that the app has an intuitive interface to track PrEP adherence. However, participants highlighted areas needing improvement, including chart titles and the inclusion of ‘undo’ and ‘edit’ buttons to improve user control when recording PrEP use.

CONCLUSIONS

Conclusions: Usability evaluations should be considered in the app’s development to ensure the effectiveness of the app’s future iterations.

CLINICALTRIAL
Enhancement of Nutritional Value of Fermented Buttermilk using Vitamin A and D
Authors: Vidhauliya Yogesh , Singh Bhopal , Kumar Akhilesh
Published: June 2024

The demand of butter milk is increasing in the dairy industry. Traditionally, buttermilk is produced from curd or cultured milk. This study demonstrates that buttermilk has become a daily dietary drink with high nutritive value including vitamin A and D. process of buttermilk first taking pasteurized milk after boiling at 40ºC in the present paper, a study was conducted for the development and characterization of functional cultured buttermilk utilizing vitamin A and D as per the standards of Recommended Dietary Allowance. The significance of the study is to increase the shelf life of product and to enhance the nutritional value by fortification of buttermilk for the consumption of human health. During fortification process other physical properties of buttermilk were not changed.
ToDoJoyComplete
Authors: Beagles John
Published: June 2024

ToDoJoyComplete is a short 3D digital film (approximately 6 minutes) by the collaborative duo Beagles and Ramsay.A speculation about digital aesthetics, the film combines the experimental use of 3d animation software with insights from Beagles’ published research on the impact of digital culture. The film shows a number of disconnected figures moving and occupying an anonymous artificially-lit and disorientating interior that is reminiscent of a contemporary art installation. A dehumanised voiceover comprises the key feature of the soundtrack. Since its first presentation in 2016, at The Scottish Endarkenment: Art and Unreason 1945 to the Present, Dovecot Gallery, Edinburgh from 13 May – 29 August 2016, the film has been shown in different iterations in 5 national and international venues including London, Glasgow and Copenhagen. See Significance, page 17 for full list.
Stolen Voices
Authors: Collins Rebecca
Published: June 2024

Stolen Voices is a multi-component output consisting of four performances, an album, a peer-reviewed journal article and a book publication. The output is a collaboration between Rebecca Collins (University of Edinburgh) and Johanna Linsley (University of Dundee). Stolen Voices forms part of their five-year (2014–2019) project which invests eavesdropping as a method, combining this with a semi-fictional detective story. An ‘event’ has taken place in 4 sites on the UK coast (Bournemouth, Felixstowe, Seaham in County Durham and Aberdeen) and Collins & Linsley have been tasked to investigate. Eavesdropping is both subject and methodology of the research. Fieldwork in the form of site explorations and the practise of eavesdropping is combined with research into social, political and economic dynamics at the borders and margins of the UK, such as immigration and the impact of climate change on coastal landscapes. Outputs: see Appendix, page 28.
Re-Created Pictish Drinking Horn Mount
Authors: Gray Jennifer
Published: June 2024

The output, a re-created Pictish drinking horn mount, is a bespoke silver mount fitting, hand-made by Jennifer Gray. The output is the result of Gray’s research investigation into the re-creation of historical artefacts in order to bring new visibility to, and understanding of, material processes and techniques that are now forgotten or little-known. The design was inspired by early medieval objects in the collection of the National Museum of Scotland (NMS). The work was commissioned by the National Museum of Scotland (NMS) and The Glenmorangie Company as part of The Glenmorangie Early Medieval Research Project, which set out to re-examine objects from the period c.300–900AD in collaboration with artists and designers.The mount was presented at the exhibition Creative Spirit, at the National Museum of Scotland, Edinburgh, 5 January – 24 February 2014. It was subsequently exhibited at the All Makers Now? conference at Trelissick House, Truro, England, 10 – 11 July 2014, and the Journées Particulières, at the Glenmorangie Distillery, Tain, Ross-shire organised by Louis Vuitton, Moët, Hennessy (LVMH) 20 – 22 May 2018.
The Magazine
Authors: Mason Alan
Published: June 2024

The Magazine is an experimental novel conceived as a series of 13 books, written and illustrated by Mason and produced over a decade. The novel was commissioned by the independent publishers, The Caseroom Press (University of Lincoln.) To date, three books have been published. (January, Autumn 2013, February, Summer 2015 and March, Spring 2019). The Magazine takes its inspiration from Victorian illustrated compendia. It employs the inherent multiplicity of the compendium form to explore ideas of authorship, narrative and relations between text and image.
Polterheist
Authors: Renhard Emma
Published: June 2024

This practice based output consists of a body of costume designs created by Emma Renhard for the original British fiction feature film Polterheist (2018). Renhard’s costumes created an original visual language for this film about gangsters, missing money and a physic medium. The costume design was produced on a budget of around £7K, within an overall production budget of £70K, and as such the research was also an experiment in how to produce high quality costumes within financial limits. The film premiered as part of the British Independent Film Festival, Leicester Square London 2018. It has been selected for a number of independent film categories, including Out of the Can Festival and Toronto Indie Horror Festival.
The 306
Authors: Williams Gareth
Published: June 2024

The 306 is a trilogy of music-theatre works co-created by composer Gareth Williams and writer Oliver Emanuel that explore the stories of the 306 British soldiers executed during World War 1. Many of these 306 men, executed for cowardice, desertion and mutiny are not listed on any official memorials, even after they were conditionally pardoned by the British Government in 2006. This work gathered all of these names for the first time, listing them in song to complete the trilogy. As a part of 14-18 NOW (the UK-wide commemorative cultural program of work from 2016 – 2018) The 306 explored ideas of heroism and protest, by looking at this lesser known, deliberately forgotten, part of our national storyabout the cultural legacy of World War 1. Drawing on primary documents such as letters and telegrams from the front lines, protest songs and documents describing the women’s peace movement in Glasgow, music hall and classical repertoire, as well as contemporary interviews with family members of those executed for cowardice during WW1, the stories and songs were developed continuously from 2013 through to 2018, in residencies, workshops, and rehearsals. 306 Dawn and 306 Day were written for an ensemble of singing actors, and Red Note Ensemble (piano, violin and cello), while 306 Dusk was created for three singing actors, piano, string quartet, and community choir of 40 singers formed in Perth for the production. Throughcomposed across different productions in three consecutive seasons, the work challenges and progresses the role and status of live music in Scottish theatre. The music has been recorded as an album, funded by the Imperial War Museum, and was released by the National Theatre of Scotland in 2020.
Sculpting the Spirits
Authors: Mendelle Noe
Published: June 2024

Mendelle and Luis Correia (co-director & co-producer) were the first filmmakers to visit the Bijagós archipelago and, after spending time with the village chiefs, were invited by them to film their daily life, beliefs, and rituals. Mendelle and her team lived with them for extended periods, twice yearly for 5 years. The elders, alert to radical changes coming their way and conscious that their culture is only orally transmitted, saw a unique opportunity to document their way of life and preserve it for future generations. Their collaboration was essential, both in terms of access and understanding the meaning of their rituals, but more importantly how they perceived change. The film gives voices to the Bijagós in their language without any commentary.However, unknown to the film makers and the islanders at the time, the film ended up capturing their downfall and their absorption into a modern capitalist and global society. The film explores how, in the context of a tribe, the dialogue between generations involves other layers of power beyond the living and how their philosophy of life will be affected by their cultural transformation. Through observation of two main protagonists in a father/son relationship, the audience begins to understand the cultural gap growing between two generations. This is universal to most cultures, but for the Bijagós any change threatens the equilibrium between human beings, nature and the spirits who contribute to tribal decisions about daily and social life. The film premiered 15 September 2014 at the Gulbenkian Museum of Modern Art, Lisbon, Portugal.
Lichtsuchende
Authors: Murray-Rust Dave
Published: June 2024

Lichtsuchende is an interactive installation that investigates relations between humans and robots. It consists of a group of robotic sunflowers that use light as a form of communication. It was created by Murray-Rust in collaboration with the design researcher Dr Rocio von Jungenfeld. It has been exhibited at nine international venues, including Edinburgh’s Hidden Door Festival (2014), the New Technology Art Awards, Ghent (2014) and GLOBALE: ExoEvolution (2015), curated by media theorist Peter Weibel, at the Center for Art and Media, Karlsruhe, Germany – an important international venue for technological art. The work has reached audiences in excess of 40,000.Lichtsuchende was awarded the 2019 Lumen Prize, the British Computing Society Award for Artificial Intelligence and Art, which celebrates the best work created annually using art and technology from across the globe.
Neutrosophic equivalence relation applied on incline algebra
Authors: Muralikrishna Prakasam , Manokaran Surya
Published: June 2024

Researchers have great interest in working in thefields of fuzzyalgebra and its substructure. Nowadays, the work on fuzzy algebrahas attained the greatest height. Considering the incline algebra in thisstudy, the concept of the neutrosophic equivalence relation in inclinealgebra and its related properties are introduced. Furthermore, thecharacteristic function and chain conditions are also analyzed, withsome results.
Impact of Biosorption Process on Industrial Waste Water Treatment in Panipat District, Haryana
Authors: Maan Ritu , Mathur Dr. Priyanka , Sharma Dr. Anil Kumar
Published: June 2024

Abstract: In this research paper, I have thoroughy described about the topic “Impact of Biosorption Process on Industrial Waste Water Treatment in Panipat District, Haryana.” The industrial wastewater pollution plaguing Panipat District, Haryana, poses a complex environmental challenge due to the diverse range of industrial activities in the region, including textiles, petrochemicals, and leather processing. This pollution, characterized by the discharge of heavy metals, dyes, organic compounds, and other contaminants into water bodies, threatens both aquatic ecosystems and public health. Conventional physical and chemical treatments have proven inadequate or environmentally harmful, necessitating the exploration of ecofriendly alternatives. Biosorption, a biotechnological method employing live or dead biomass to remove pollutants from wastewater, emerges as a promising solution owing to its cost-effectiveness, efficiency, and low environmental impact. This study explores the efficacy of biosorption techniques in mitigating industrial wastewater pollution in Panipat District, evaluating various biosorbents' performance and efficiency in pollutant removal. Results indicate remarkable reductions in pollutant concentrations, with activated carbon achieving a removal efficiency of 96% for chromium, agricultural residues demonstrating a removal efficiency of 95% for dyes, and microbial biomass exhibiting an 87.5% removal efficiency for organic compounds. Furthermore, biosorption processes contribute to cost savings, regulatory compliance, water quality enhancement, resource recovery, positive public perception, and long-term sustainability, positioning them as integral components of environmentally responsible industrial practices in Panipat. This research bridges scientific inquiry with practical application, advocating for the widespread adoption of biosorption technologies to address industrial wastewater challenges, protect ecosystems, and safeguard communities in Panipat District and beyond.
Blockchain-Based Car Rental Platform
Authors: Dwivedi Aman , Sharma Divyansh , Gumber Sharad , Gupta Satyam
Published: June 2024

Abstract: Carpooling has seen a significant upsurge in popularity in recent years since it relieves commuters of the burden of driving a car and later spares them from the mad dash to locate a parking space. The industry now uses centralised database servers, which puts the system at risk of hacking, causes data leaks, and undermines security within the system. Additionally, there is a chance that the owner will misuse the data in a centralised system. Since the newly developed Blockchain technology provides complete anonymity and database transparency, data security and traceability may be guaranteed across the entire server. The goal of the suggested solution is to create and implement a blockchain-based, smart contract-based peer-to-peer vehicle sharing system. The Solidity programming language is utilised to carry out the smart contracts. Ethereum blockchain is used in the ecosystem's construction. Eliminating the middleman would result in a peer-to- peer (P2P) car-sharing programme, which would reflect decreased costs and exposure to data theft.
A Comparative and Experimental Study of Parametric Influence on Drilling Process of Hybrid AMMC
Authors: Mahendran Dr. S. , Sukumar Dr. S.
Published: June 2024

Abstract: To aim for the highest quality product quality and a high metal removal rate, metal cutting is crucial. The primary obstacle to attaining optimal quality and high production is the short tool life. The hybrid aluminum metal matrix AA 6082, with reinforcement consisting of titanium dioxide (7.5%) and cenosphere (2.5%), was optimized using the Modified Taguchi optimization method for simultaneous minimization and maximization of surface roughness (Ra), machining time, and material removal rate. The surface finish was affected by different types of geometrical precision values of the CNC drilling process parameters in order to both minimize and maximize the responses. The experiments, including call for the machining of hybrid AMMC and the use of an HSS drill bit, will be performed using a CNC with different process parameters. The L16 orthogonal array will be used for the examinations, and each experiment will be run under a distinct set of circumstances, including feed, speed, and pecking. Using the TAGUCHI design, the optimal geometrical and machining parameters were determined from the experimental output responses, and significant influences were discovered for the corresponding specific output responses.