bluuebunny/crossref_metadata_2025 huggingface dataset:
DBP2Vec: Predicting DNA-binding proteins directly using pre-trained protein language model
Authors: Wei Chao , Ye Zhiwei , Wang Panru , Lan Wuyang
Published: May 2023

DNA-binding proteins (DBPs) play a crucial role in numbers of biological processes and have received wide attention in recent years. Meanwhile, the rapid development of sequencing technologies lead to the explosive growth of new protein sequences, it is highly desired to develop a fast and accurate method for DNA-binding proteins prediction. Experimental methods such as chromatin immunoprecipitation on microarray (ChIP-chip) and X-ray crystallography are highly accurate but expensive and time-consuming. To address this issue, many computational methods have been proposed, they usually exploit multiple information about protein sequence, e.g., sequence composition information, physicochemical properties, evolutionary information, structural information, etc. Despite the effectiveness of these approaches, they heavily depend on prior biological knowledge and undergo a very complex process of feature extraction. In view of these shortcomings, here, we present a novel method, named DBP2Vec, to predict DNA-binding proteins directly from pre-trained protein language model (e.g., ESM-1b) which effectively encode biological properties without any prior knowledge by virtue of deep representation learning (e.g., BERT) on large protein sequences databases (e.g., UniParc). Tests on two benchmark datasets (e.g., PDB296, UniSwiss-Tst) and one newly constructed DBPs dataset demonstrate that our proposed method significantly outperforms existing state-of-the-art methods.
Application of groundwater quality index (GWQI) by Deterministic and Probabilistic Approaches to Assess Effect of Land Use Change on Groundwater Quality in the northern county of Iran: non-carcinogenic risk assessment
Authors: Faraji Hossein , Javanian Mostafa , Mohammadpour Amin , Chavoshi Ebrahim , Rezaei Fatemeh , Badeenezhad Ahmad , Nikbakht Hossein-Ali
Published: May 2023

This study aimed to evaluate the groundwater quality, land use changes, and non-carcinogenic risk caused by F−, and NO3 – ions in Babol county's drinking water. A total of 228 samples were collected from 38 drinking water wells between 2016–2021, and analyzed for various chemical parameters to determine the groundwater quality index (GWQI). The results obtained from the deterministic approach indicated that 74.6% of the water sources exhibited good quality, with a GWQI value range of 49.91 to 107.38. However, the Probabilistic Approach revealed that only 0.01% of the water samples demonstrated excellent quality, while the majority (98.37%) were classified as having good quality, with a smaller proportion (1.6%) considered poor. The qualitative zoning of GWQI showed that part of the studied area on the shores of the Caspian Sea and the north of the region is in an unfavorable condition. Principal component analysis (PCA) on parameters of chemicals showed three factors that account for 71.55% of the total variance in the groundwater quality data set. The land use results showed that in residential areas where the population is dense, a higher concentration of NO3− is observed. The study also found that the non-carcinogenic risk caused by F− and NO3− was below the risk limit (HQ < 1) for all age groups, except for infants in the wet season where 18.4% of the HQF values were greater than 1. The results showed that NO3− concentration had the highest effect on the non-carcinogenic risk in all age groups. This study highlights the importance of monitoring and managing land use changes to maintain the quality of drinking water in Babol County.
The causal relationship of gut microbiota in progression of seven common hematological malignancie
Authors: He Xiaoyu , Wang Xiaofang , Yang Kaiqian , Nie Duorui , Gang Dongxu , Jiang Songfu
Published: May 2023

Purpose: Evidence from observational researches and clinical trials showed the relationship between gut microbiomes (GMs) and hematological malignancies. Nevertheless, the causal role of GM taxa in development of hematological malignancies remains to be explored. Therefore, we aim to assess the causal links between 196 GM taxa and seven common hematological malignancies using the two-sample Mendelian randomization (MR) analyses.
Methods: All datasets were derived from published genome-wide association studies (GWAS) statistics. The primary analysis was performed using random effects inverse variance weighted (IVW). To verify the robustness of the MR results, we performed several sensitivity analyses such as Egger intercept test, the Cochran Q test, MR pleiotropy residual sum and outlier (MR-PRESSO), and leave-one-out analysis.
Results: We revealed the family Oxalobacteraceae would increase the risk of myeloid leukemia by the Bonferroni correction [odds ratio (OR): 2.08, 95% CI: 1.49, 2.90, p = 1.68E-05]. In addition, 22 nominally significant associations between genetic liability in GMs and hematological malignancies were also found (P < 0.05). Sensitivity analysis verified the robustness of the above causal relationships.
Conclusion: This study confirms the causal relationship between GMs and hematological malignancies and may provide new insights to the mechanistic and clinical researches of GM-mediated hematological malignancies.
Salvage prostate bed plus elective pelvic node radiation without androgen deprivation therapy
Authors: Swanson Gregory P. , Hammonds Kendall , JHAVAR SAMEER
Published: May 2023

Background and purpose:
In men with biochemical recurrence (BCR) of prostate cancer (PCA) after radical prostatectomy (RP), there is limited data on effectiveness of adding elective pelvic nodal radiation (EPNI) to salvage prostate bed radiation (PBRT) without androgen deprivation therapy (ADT) to prevent progression.
Materials and Methods:
Retrospective chart review of 326 patients treated for BCR of PCA from a single institution was performed to capture baseline pre-operative PSA, pathologic details, post-operative PSA, treatment details (radiation and ADT), subsequent failure (rising PSA), response to radiation, and subsequent outcomes after radiation.
Results:
Between 2004 through 2017, 326 patients received PBRT. Majority (n = 253; 78%) did not receive ADT. Majority received EPNI (n = 227; 90%) with salvage PBRT (n = 213; 94%). The median pre-PBRT PSA was 0.50 ng/ml (0.10–75.60 ng/ml). Of the patients that did not receive ADT, 83% (210/253) achieved an undetectable (< 0.2 ng/ml) PSA after salvage PBRT. After a median follow up of 87 months, 172 (53%) patients were without a rising PSA and 50 (15%) developed metastatic disease.
Conclusion:
Outcomes with salvage PBRT plus EPNI without ADT appear comparable to salvage PBRT plus EPNI plus ADT. These results need confirmation in a randomized setting.
A 1:1 matched case-control study: Are thyroid nodules related to iodine nutrition? Can thyroglobulin(Tg) serve as a functional biomarker for thyroid nodules?
Authors: Lin Qingying , Wang Muhua , Chen Diqun , Wu Jiani , Lan Ying , Wang Lijin , Jin Qingdong , Chen Yanqing , Chen Zhihui
Published: May 2023

Background A significant increasing trend in the prevalence of thyroid nodules has resulted in shining a spotlight on whether thyroid nodules are related to the level of iodine nutrition. In this study, a 1:1 matched case-control study is conducted to investigate whether thyroid nodules are related to the level of iodine nutrition.Methods Selected three survey sites with median urinary iodine (MUI) < 100µg/L, 100–199µg/L, and 200–299µg/L. The residents who have lived there for at least 5 years with thyroid nodules were the case group, while those without nodules were the control group that matched 1:1 with the case group by age (± 3 years), gender and region. All subjects completed questionnaires, collected blood and urine samples.Results The MUI of the case group in the areas with more than adequate iodine intake was lower than that of the control group(P < 0.05); Only the level of Tg of the case group was higher than that of the control group in the areas with adequate iodine intake(P < 0.05).The conditional Logistic regression model resulted that there were statistically significant correlations between history of thyroid disorders, Tg, TgAb and thyroid nodules.Conclusions When in the areas with more than adequate iodine intake, a slight increase in urinary iodine may help inhibit the occurrence of nodules. History of thyroid disorders, increased Tg and TgAb levels were risk factors for thyroid nodules. Tg can serve as a functional biomarker for thyroid nodules.
The experiences of intensive care nurses coping with ethical conflict: a qualitative descriptive study
Authors: Liu Yuanfei , Ying Liying , Zhang Yuping , Jin Jingfen
Published: May 2023

Background
The critical conditions and life risk scenarios make intensive care nurses susceptible to ethical conflict. Negative consequences were recognized at both the individual level and the professional level which highly compromised the patient care and nurses’ well-being. Therefore, ethical conflict has become a major concern in nursing practice. However, the experience of coping with ethical conflict among intensive care nurses remains unclear.
Aims
This study aims to explore the experience of intensive care nurses coping with ethical conflict in China.
Methods
From December 2021 to February 2022, in- depth interviews with 15 intensive care nurses from five intensive care units in a tertiary general hospital in China was performed using purposive sampling. An inductive thematic analysis approach was used to analyze the data. We applied the consolidated criteria for reporting qualitative research for this study.
Results
Two distinctive themes were found: detachment and engagement, which contained four subthemes: ignoring ethical problems in the workplace, seeking ways to express emotions, perspective-taking, and identifying positive assets. Theses coping strategies demonstrated an ongoing process with different essential features. Intensive care nurses acquired skills and experience to form more mature and well-adapted coping strategies.
Conclusion
This study provides a new insight into the experience of intensive care nurses coping with ethical conflict in clinical nursing. Intensive care nurses demonstrated differential experience of coping with ethical conflict in clinical nursing including problem-focused, emotion-focused and meaning-making strategies. These findings have implications for policymakers and nursing administrators to develop ethical education and training and supportive environment for intensive care nurses to tackle this issue.
In silico study identifies hub genes and regulatory network associated with the pathogenesis of Japanese Encephalitis Virus
Authors: Kumar Arvind , Chand Gyanandra Bahadur , Azad Gajendra Kumar
Published: May 2023

Japanese encephalitis (JE) is a mosquito-borne viral disease caused by the Japanese encephalitis virus (JEV). Approximately 3 billion people from South-East Asia are at risk of this disease; however, the pathogenesis mediated by this virus is still elusive. Therefore, this study was undertaken to identify hub genes and regulator network associated with JE pathogenesis using several computational tools. Our data revealed VEGFA and WNT5A genes as major contributing factors for the development of primary stage of invasive JEV. These two genes were found to be regulated by transcription factor and miRNA targets from multiple databases. The analysis revealed that the activation of VEGFA and WNT5A is mediated by several transcription factors that include EGR1, EPAS1, ETS1, FOS, HIF1A and GLI3, GLI2, GLI1, respectively. Furthermore, we also identified several miRNAs that regulates the repression of VEGFA and WNT5A and also measured their seed pairing and binding free energy of gene-miRNAs interactions. The mathematical modelling supports the role of above mentioned miRNAs in the initiation of the regulatory pathogenesis in JEV. Additionally, we have shown that the type 1 and type 2 coherent and incoherent feed forward loops help to determine the VEGFA gene regulation by TFs and miRNAs. Altogether, this study demonstrates the regulation of JEV pathogenesis by WNT5A/VEGFA and associated miRNAs.
Paleoecological inferences about the Late Quaternary giant ground sloths from the Americas
Authors: Dantas Mário A. T. , Campbell Sean Cody , McDonald H. Gregory
Published: May 2023

The Occlusal Surface Area index together with the body mass contribute to better understanding the paleoecology and evolution of the giant sloths in the Americas. The giant sloths from southern South America probably had higher levels of fermentation/lower metabolic requirements, whereas the tropical taxa had higher metabolic requirements. The sloths that dispersed into Central and North America were most likely derived from tropical taxa based on the patterns observed in this study. Relative Muzzle Width and the Hypsodonty indices were used to infer the dietary adaptation of several late Pleistocene/early Holocene giant ground sloths from the Americas. The Nothrotheriidae and Megatheridae taxa were adapted to a browser or mixed-feeder “browser” diet, the Mylodontidae taxa to a variety of dietary types, and the Megalonychidae taxa to a mixed-feeder browser diet. However, these dietary adaptations do not necessarily reflect food niches. In general, Megalonychidae and Nothrotheriidae were climber species, Mylodontidae taxa were digger species, and Megatheriidae taxa were fully terrestrial species.
Determining the petrophysical rock types utilizing the Fuzzy C-means Clustering technique and the concept of hydraulic flow units
Authors: Eftekhari Seyedeh Hajar , Memariani Mahmoud , Maleki Zahra , Aleali Mohsen , Kianoush Pooria
Published: May 2023

Rock types are the reservoir's most essential properties and show special facies with a defined range of porosity and permeability. This study used the fuzzy c-means clustering technique to identify rock types in 280 core samples obtained from one of the wells drilled in the Asmari reservoir located in the Mansouri field. Four hydraulic flow units were determined for studied data after classifying the flow zone index with histogram analysis, normal probability analysis, and the sum of square error methods. Then the two methods of flow zone index and fuzzy c-means clustering were used to determine the rock types in given wells according to the results obtained from the implementation of these two methods in-depth, and continuity index acts, the fuzzy c-means methods with continuity number 3.12 compared to flow zone index with continuity number 2.77 shows more continuity in depth. Amounts of porosity and permeability of the different reservoir rock samples have high dispersion; the relationship between these two parameters improves by using hydraulic flow unit techniques significantly. In this study, the relationship between porosity and permeability of correlation coefficient improves and increases in each hydraulic flow unit by using the flow zone index method so that in the general case for all samples increased from 0.55 to 0.81 in the first hydraulic flow unit, 0.94 in the second hydraulic flow unit, 0.85 in the third hydraulic flow unit and 0.94 in the fourth hydraulic flow unit that this is because the samples were characterized by similar flow properties in a hydraulic flow unit. In comparison, the correlation coefficient is obtained less than the general case in the fuzzy c-means method in all hydraulic flow units.
Coronary Artery Calcium (CAC) Score for Cardiovascular Risk Stratification in a Thai Clinical Cohort: A Comparison of Absolute Scores and Age-Sex Specific Percentiles
Authors: Kitjanukit Supitcha , wongyikul Pakpoom , Kuanprasert Srun , Suwannasom Pannipa , Phrommintikul Arintaya , Phinyo Phichayut
Published: May 2023

Purpose
This study aims to examine the prevalence and CAC distribution and to evaluate the association of each CAC classifications with major adverse cardiovascular event (MACE).
Method
This study was a retrospective observational cohort. We included patient aged above 35 years who underwent CAC testing. The absolute and age-sex specific percentile classification were categorized as 0, 1 to 10, 11 to 100, 101 to 400, and > 400 and 0, < 75th, 75th – 90th, and > 90th, respectively. The end point was MACE, including cardiovascular death, myocardial infarction, heart failure hospitalization, coronary artery revascularization procedures, and stroke. Multivariable Cox regression was used to estimate the hazard ratios. The discriminative performance between classification were compared using Harrell’s C-statistic. The agreement was assessed via Cohens’ Kappa.
Result
The study included 440 patients, with approximately 70% of Thai patients exhibiting a CAC score. CAC distributed higher in male than female and older than younger. Both CAC classification demonstrated the acceptable predictive performance. However, fair agreement was observed between classifications (Cohen’s kappa 0.51 95%CI 0.42–0.59). Within an absolute classification, the higher CAC could capture the higher hazard ratio more consistently across age-sex specific percentile level. In contrast, the association between MACE and the age-sex specific percentile classification was not consistent in all levels of the absolute CAC scale.
Conclusion
Both absolute and age-sex-specific percentile CAC scores showed acceptable performance in predicting MACE. However, it is likely that the classification of absolute CAC scores may be more appropriate for risk stratification in Thai clinical cohort.
A novel hierarchical carbon price forecasting model with local and overall perspectives
Authors: 益 帆许 , Che Jinxing
Published: May 2023

Existing carbon price decomposition methods make effective predictions, promote energy saving and emission reduction, and play an increasingly important role in carbon trading platforms. However, few studies have been conducted on the reorganization methods and different perspective treatments of the decomposition components. In this paper, a new component fusion method is introduced, based on this, a hierarchical carbon price prediction model with two levels—one for a local perspective and one for an overall one—is developed. Firstly, the carbon price data are decomposed and the resulting components are subjected to deviation sample entropy fusion, which classifies them into high, medium, and low frequencies according to the physical significance of the entropy values. Next, fine-grained predictions are performed for the high, medium and low frequency components, defining this step as the local layer. Subsequently, the decomposition error correction is proposed to obtained the data of the overall layer, and a secondary decomposition of this data is done. Finally, the prediction values of the two levels are summed to obtain the final prediction results. The experimental results in three markets, Guangdong, Tianjin and Beijing, show that the proposed fusion method can directly find the best component recombination scheme and the model prediction ability is better than the conventional secondary decomposition model.
Comparison between open reduction and internal fixation and minimally invasive plate osteosynthesis for unstable proximal humerus fractures treated with locking plate and intramedullary allograft: a retrospective study
Authors: Rusimov Lyubomir , Baltov Asen , Enchev Dian , Gueorguiev Boyko , Prodanova Krasimira , Hadzhinikolova Mariya , Rusimov Vladimir , Rashkov Mihail
Published: May 2023

Background
The aim of this study was to compare the functional and radiological outcomes between open reduction and internal fixation (ORIF) and minimally invasive plate osteosynthesis (MIPO) with locking plate (LP) and intramedullary graft (IMG) for treatment of unstable proximal humerus fractures (PHFs).
Methods
Forty-seven patients with PHFs were treated with ORIF and MIPO techniques in 25 and 22 cases, respectively, and evaluated retrospectively with a minimum follow-up of 12 months. Thirty-one fresh-frozen fibulae and 16 lyophilized tibiae allografts were used for augmentation. Radiological evaluation included the change in neck-shaft angle (NSA) and humeral head height (HHH). Functional outcomes were assessed using DASH and absolute Constant-Murley Score (CSabs) with its derivatives: relative (CSrel) and individual relative (CSindiv).
Results
Mean follow-up period was 27.4 ± 16.2 months for ORIF and 29.6 ± 17.6 for MIPO group. Mean age was 60.5 ± 13.7 and 66.3 ± 11.7 years for ORIF and MIPO group, respectively. Functional outcomes showed insignificant difference between the groups: CSabs of 57.3 ± 21.2 in ORIF and 52.4 ± 18.9 in MIPO group, (p = 0.409); CSrel of 73 ± 24.1 in ORIF and 73.9 ± 23.4 in MIPO, (p = 0.897); CSindiv of 69.6 ± 24.8 in ORIF and 64 ± 25.5 in MIPO, (p = 0.428); DASH of 14.8 ± 12.5 in ORIF and 18.7 ± 14.5 in MIPO, (p = 0.324). There were no significant differences in radiological outcomes between the two groups: decrease of NSA was 7.8° ± 9.4° in ORIF and 8.2° ± 15.6° in MIPO, (p = 0.922). Decrease of HHH was 0.6 mm ± 5.5 mm in ORIF and 1.4 mm ± 2.6 mm in MIPO, (p = 0.380). Surgical time was 165.8 ± 77.6 min for ORIF and 84.7 ± 38.1 min for MIPO, with significant difference between the groups (p < 0.001). Most common complication was AVN, occurring in five (20%) and 8 (36%) patients in ORIF and MIPO groups, respectively.
Conclusions
The study found that using LP fixation and IMG augmentation to treat unstable PHFs resulted in similar functional and radiological outcomes between the ORIF and MIPO techniques. However, the MIPO technique had a significantly shorter surgical time compared to ORIF.
Trial registration
The study was conducted in line with the principles of the Declaration of Helsinki as well as national legal and regulatory requirements. The trial was retrospectively registered and approval was granted by the local Ethics Committee of University Multiprofile Hospital for Active Treatment and Emergency Medicine “N. I. Pirogov”, Sofia, Bulgaria: (No. EC – 01/26.01.2023).
Fast Approximation Methods for Credit Portfolio Risk Calculations
Authors: Jakob Kevin , Churt Johannes , Nolte Kim , Fischer Matthias , Okhrin Yarema , Sondermann Dirk , Wilke Stefan , Worbs Thomas
Published: May 2023

Credit risk is one of the main risks financial institutions are exposed to. Within the last two decades simulation-based credit portfolio models became extremely popular and replaced closed analytical ones as computers became more powerful. However, especially for non-homogenous and non-granular portfolios a full simulation of a credit portfolio model is still time consuming, which can be disadvantage within some use cases like credit pricing or within stress testing situations where results must be available very quickly. For this purpose, we investigate if methods based on artificial intelligence (AI) can be helpful to approximate a credit portfolio model. We compare the performance of AI-based methods within three different use cases with those of classical regression methods. As a result, we see that generally AI-based methods are able to capture portfolio characteristics and to and speed-up calculations but depending on the specific use case and the availability of training data they are not necessarily always the best choice. Particularly, considering the time and costs for collecting data and training of the complex algorithms, classical methods can be as good as or even better as AI-based ones with less effort.
Four classic “de novo” genes all have plausible homologs and likely evolved from retro-duplicated or pseudogenic sequences
Authors: Bozorgmehr Joseph Hannon
Published: May 2023

Despite being previously regarded as extremely unlikely, the idea that entirely novel protein-coding genes can emerge from non-coding sequences has gradually become accepted over the past two decades. Examples of “de novo origination”, resulting in lineage-specific “orphan” genes, lacking orthologs, are now produced every year. However, many are likely cases of duplicates that are difficult to recognize. Here, I re-examine the claims and show that four very well-known examples of genes alleged to have emerged de novo “from scratch” - namely FLJ33706 in humans, Goddard in fruit flies, BSC4 in baker’s yeast and AFGP2 in codfish - all have plausible evolutionary ancestors in pre-existing genes. In the case of the first two, highly diverged retrogenes that code for regulatory proteins may have been misidentified as being orphans. The antifreeze glycoproteins in cod, moreover, are shown to have likely not evolved from repetitive non-genic sequences but, as in other related cases, from an apolipoprotein that may well have been pseudogenized before later being reactivated. These findings detract from various claims made about de novo gene birth and show there has been a tendency not to invest the necessary effort in searching for homologs outside of a very limited syntenic or phylostratigraphic methodology. An approach used here for improving homology detection draws upon similarities, not just in terms of statistical sequence analysis, but also with biochemistry and function, in order to obviate failure.
Circulating microRNAs and hepcidin as predictors of iron homeostasis and anemia among school children: a biochemical and cross-sectional survey analysis
Authors: Al-Rawaf Hadeel A. , Gabr Sami , Iqbal Amir , H. Ahmad H. Ahmad
Published: May 2023

Background
MicroRNAs (miRNAs) had the ability to control several biological processes. Thus, the exisstance of these mlecules play a significant role in regulating human iron metabolism or homeostasis.
Purpose
The study aimed to determine the role of circulating microRNAs and hepcidin in controlling iron homeostasis and evaluating possible anemia among school children.
Methods
The study was based on a biochemical and cross-sectional survey study that included three hundred fifty school children aged 12–18 years old. RT–PCR and immunoassays analysis were accomplished to estimate iron concentration, Hgb, serum ferritin(SF), soluble transferrin receptor (sTfR), total body iron stores(TIBs), total oxidative stress(TOS), total antioxidant capacity(TAC), α-1-acid glycoprotein (AGP), high sensitive C-reactive protein (hs-CRP), and miRNAs; miR-146a, miR-129b, and miR-122 in 350 school adolescents.
Results
Iron disorders were cross-sectionally predicted in 28.54% of the study population; they were classified into 14.26% with ID and 5.7% with IDA, and 8.6% with iron overloaded. The overall proportion of iron depletion was significantly higher in girls (20.0%) than in boys(8.6%). MicroRNAs; miR-146a and miR-125b, and miR-122 were significantly upregulated with lower hepcidin expression in adolescence with ID and IDA compared to iron-overloaded subjects, whereas down-regulation of these miRNAs was linked with higher hepcidin. Also, a significant correlation was recorded between miRNAs, hepcidin levels, AGP, hs-CRP, TAC, and other iron-related indicators.
Conclusion
Molecular miRNAs; miR-146a and miR-125b, and miR-122 were shown to provide an additional means of controlling or regulating cellular iron uptake or metabolism either via oxidative stress pathway or regulation of hepcidin expression via activating genes encoding Hfe and Hjv activators which promotes iron regulation.
Ant habitat-use guilds response to forest-pasture shifting in southwestern Amazon
Authors: Dutra Dhâmyla Bruna Souza , Feitosa Rodrigo Machado , Jory Tainara Thais , Sales Francisco Matheus Silva , Fontenele Luane Karoline , Costa Marília Maria Silva , Schmidt Fernando Augusto
Published: May 2023

Ant assemblages have been used as bioindicators of the response of biodiversity to different types of anthropogenic disturbances. However, usual diversity metrics (e.g., ant species richness and composition) sometimes seem fair limited to show a general panorama of human impacts. Thus, we verified habitat-use ant guilds as a complementary predictable parameter, based on the ant fauna reported to thirteen forest fragments and pastures in southwestern Brazilian Amazon. Specifically, we hypothesized that forest specialist, open-habitat specialist, and generalist ants would present distinct responses to forest-pasture shifting. We expected that the forest-pasture shifting promotes a decrease in the species richness of forest specialists and an increase in open-habitat specialists, while the generalists would have few changes in their richness because they can live in both habitats. As expected, the species richness of forest specialist ants decreased, and open-habitat ants increased with forest-pasture shifting, while generalists had few changes. This indicates that in human-induced open habitats (e.g., pastures) are essentially made up by generalist ants and open-habitat ant specialists that replace forest specialists. Additionally, considering the plasticity of generalist ants, they can be considered as primary elements of ant assemblages. Therefore, a future step is to quantify the limit of forest cover clearing in human-induced land uses that assure a higher species richness of forest-specialist ants than other habitat-use guilds.
A Multi-modal Fusion-based Sentiment Analysis Model for Short Videos
Authors: Prescott Asher , Throne Juniper , Callahan Sullivan , Harper Matilda
Published: May 2023

It is in this information era, leading to the majority of users increasingly like to publish their views online and express their feelings through the form of text pictures and videos, such as Facebook, Instagram, and other social platforms used by a large number of users every day to record their daily life, and through these recorded documents can well reflect the mood of the time. By analyzing these data, researchers can gain insight into users' favorite preferences, and according to their preferences, they can provide precise services to users, thus improving their satisfaction. The traditional approach is limited to linear combinations of sentiment words and rough sentiment classification, to solve the problem of machine learning classification methods. In the deep learning-based image emotion classification method, let the network achieves the method of extracting the significant features of the image by combining the underlying features to form a higher-level feature representation with a more abstract nature. For short videos with complex semantic information and single modal video sentiment analysis often cannot fully express the sentiment tendency of the video. In this paper, we propose a short video sentiment analysis method that incorporates every modal. In the text modality, the text modality data are firstly preprocessed by using the word separation tool, then the word vector corresponding to the text is obtained by using the word embedding tool, and the obtained word vector is used to extract the sentiment features of the text information by using the LSTM network with attention mechanism, and finally the sentiment probability of the text information on the three categories of positive, neutral and negative is calculated by the classifier. On the short video modality, the video feature extraction method of 3D residual dense network is used to establish the video sentiment classification model, and the classifier is used to determine the sentiment probability of short video information. The experiments on several datasets validate the effective performance of our model.
Uniform sampling of simple graphs with prescribed degrees and experimental algorithms for external memory
Authors:   , Hung The Hung The
Published: May 2023

Die Emergenz digitaler Netzwerke ist auf die ständige Entwicklung und Transformation neuer Informationstechnologien zurückzuführen. Dieser Strukturwandel führt zu äußerst komplexen Systemen in vielen verschiedenen Lebensbereichen. Es besteht daher verstärkt die Notwendigkeit, die zugrunde liegenden wesentlichen Eigenschaften von realen Netzwerken zu untersuchen und zu verstehen. In diesem Zusammenhang wird die Netzwerkanalyse als Mittel für die Untersuchung von Netzwerken herangezogen und stellt beobachtete Strukturen mithilfe mathematischer Modelle dar. Hierbei, werden in der Regel parametrisierbare Zufallsgraphen verwendet, um eine systematische experimentelle Evaluation von Algorithmen und Datenstrukturen zu ermöglichen. Angesichts der zunehmenden Menge an Informationen, sind viele Aspekte der Netzwerkanalyse datengesteuert und zur Interpretation auf effiziente Algorithmen angewiesen. Algorithmische Lösungen müssen daher sowohl die strukturellen Eigenschaften der Eingabe als auch die Besonderheiten der zugrunde liegenden Maschinen, die sie ausführen, sorgfältig berücksichtigen. Die Generierung und Analyse massiver Netzwerke ist dementsprechend eine anspruchsvolle Aufgabe für sich. Die vorliegende Arbeit bietet daher algorithmische Lösungen für die Generierung und Analyse massiver Graphen. Zu diesem Zweck entwickeln wir Algorithmen für das Generieren von Graphen mit vorgegebenen Knotengraden, die Berechnung von Zusammenhangskomponenten massiver Graphen und zertifizierende Grapherkennung für Instanzen, die die Größe des Hauptspeichers überschreiten. Unsere Algorithmen und Implementierungen sind praktisch effizient für verschiedene Maschinenmodelle und bieten sequentielle, Shared-Memory parallele und/oder I/O-effiziente Lösungen.
Plectranthus amboinicus Essential Oil Incorporated into Fish Feed Shows Strong Antimicrobial Activity against Aeromonas hydrophila, an Opportunistic Bacterium of Aquaculture
Authors: Silva Juliane , Vilar Flávia , Lima Gabriel , Souza Elizangela , Dutra Livia , Almeida Jackson , Rolim Larissa , Lopes Norberto , Oliveira Ana
Published: May 2023

Plectranthus amboinicus is an aromatic herb often used in traditional medicine due to its antimicrobial properties. Based on it, the present study aimed to assess the toxic, antioxidant and, antibacterial properties of P. amboinicus essential oil (EO) either separated or mixed into fish feed. The chemical composition of the EO was also investigated. All samples were prepared with over 50% of carvacrol. The results revealed that the EO is a weak antioxidant and highly toxic against Artemia salina, showing greater antibacterial activity than positive control of chloramphenicol and synergistic effects. The EO also presented high antimicrobial activity against Aeromonas hydrophila strains when free or feed-incorporated, thus being a promising product for the treatment of opportunistic infections in fish.
Burkholderia cepacia-contaminated dentures possibly cause pneumonia
Authors: Matsumoto Satoshi , Morikage Noriyasu , Oie Shigeharu
Published: May 2023

We report a case in which a patient was suspected of developing pneumonia due to wearing dentures that were immersed in a storage solution contaminated with 3.0 × 108 colony-forming units (cfu)/mL of Burkholderia cepacia. It is highly possible that the contaminated denture solution entered the trachea and caused the pneumonia, possibly due to the prolonged supine positioning of the patient. We demonstrated that B. cepacia isolated from the sputum and B. cepacia isolated from the denture storage solution had the same DNA fingerprint, and that the patient recovered from pneumonia after stopping the use of dentures. These findings suggest the storage solution as the main source of infection.
Contribuições Teóricas e Metodológicas da Produção Científica sobre Observatórios de Turismo:
Authors: Pacheco Laissa , Marques Osiris , Santos-Silva Letícia Cynara
Published: May 2023

O presente estudo objetiva investigar a produção científica sobre a literatura de observatórios de turismo, levantando informações contidas nos trabalhos selecionados para elaboração de um panorama geral sobre o tema. Para isso, realizou-se uma revisão sistemática da literatura a partir da seleção da palavra-chave “observatório turismo” e suas variações em português, inglês e espanhol, buscadas em 5 bases de dados distintas. No total, 22 artigos publicados entre os anos de 2015 e 2021 foram selecionados para análise neste trabalho. Observou-se que a maior parte dos artigos possui abordagem qualitativa e utilizam como técnica de coleta de dados a aplicação de questionários. Foram apontados ainda os periódicos que mais publicaram sobre observatório de turismo, bem como as localidades mencionadas pelos artigos como objetos de análise. Identificou-se também uma pluralidade de temáticas relacionadas a observatórios de turismo, como: governança, gestão, planejamento, sistema de informação, conhecimento científico, entre outros. A partir da apreciação das contribuições teóricas e metodológicas dos artigos, constata-se que os observatórios de turismo, mais que facilitadores, são ferramentas primordiais para o desenvolvimento do turismo, entretanto, necessitam do trabalho em rede, inovação em gestão de dados, produção de conhecimento científico e reconhecimento legitimado para formulação de políticas públicas e tomada de decisões adequadas à realidade dos destinos turísticos.

Palavras-chave: observatórios de turismo; revisão sistemática da literatura; desenvolvimento turístico; gestão do turismo; conhecimento científico.
Por uma nova agenda de pesquisa em Turismo e Neurociências
Authors: Coelho Mariana , Maria Moreira Lopes Jéssica , Fraga Carla Conceição Lana
Published: May 2023

Compreender a relação entre memória e as experiências turísticas pode trazer inúmeras explicações sobre como os avanços de descobertas relativas ao funcionamento do cérebro auxiliam no entendimento do comportamento dos turistas e a memorabilidade das experiências. Contudo, poucos estudos empíricos e teóricos se concentraram em relacionar memória e as experiências turísticas, em especial aqueles que utilizam teorias e métodos advindos das Neurociências. Portanto, este estudo tem como objetivo geral analisar como pesquisas anteriores relacionam e incorporam a memória às experiências turísticas e como é possível avançar por essa perspectiva. Consequentemente, focando na interdisciplinaridade, a relação entre Turismo e Neurociências torna-se um guia desta revisão da literatura. A metodologia adotada foi a Revisão Sistemática de Literatura (RSL), com base na pesquisa dos termos "turismo" e "memória" na base de dados Web of Science (WoS). Complementarmente, utilizou-se a análise de redes por meio do software VosViewer. Logo, reforça-se a necessidade de se indagar sobre as experiências turísticas memoráveis com as teorias e métodos advindos das Neurociências. Visando o futuro da pesquisa em Turismo e Memórias, o artigo propõe: (i)  uma nova agenda de pesquisa sobre Experiências Turísticas Memoráveis (MTEs); e, (ii) contribuições para planejadores e gestores do Turismo.
Recent Advances in Biologically Active Ingredients from Natural Drugs
for Sepsis Treatment
Authors: Zheng Zhenzhen , Song Xiayinan , Shi Yanmei , Long Xiaofeng , Li Jie , Zhang Min
Published: May 2023

Sepsis refers to the dysregulated host response to infection; its incidence and mortality
rates are high. It is a worldwide medical problem but there is no specific drug for it. In recent
years, clinical and experimental studies have found that many monomer components of traditional
Chinese medicine have certain effects on the treatment of sepsis. This paper reviews the advances
in research on the active ingredients of traditional Chinese medicine involved in the treatment of
sepsis in recent years according to their chemical structure; it could provide ideas and references
for further research and development in Chinese materia medica for the treatment of sepsis.
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric
Cancer Identified by a Combination of Text Mining and RNA Sequencing
Authors: Kong Na , Li Wendong , Zhang Jun , Wang Xin , Hu Lin , Xu Qiqi
Published: May 2023

Introduction:

Gastric cancer is a well-known malignant tumor that causes millions of
deaths worldwide every year. Due to the lack of a specific biomarker for gastric cancer, most patients
are diagnosed at an advanced stage of the disease which results in a poor prognosis and a higher death
rate. Therefore, novel biomarkers are urgently needed for early diagnosis and to improve the survival
rate.

Methods:

In this study, we conducted RNA sequencing of tumor samples from 21 patients with gastric
cancer. A total of 3192 differentially expressed genes (1589 up-regulated and 1603 down-regulated)
were identified. Subsequently, we applied a text-mining algorithm for further analysis of these data
and selected 30 representative genes to investigate as candidates for novel biomarkers in gastric cancer.

Results:

Among these genes, we confirmed transient receptor potential melastatin 8 channels
(TRPM8) as a novel biomarker based on Western blot and immunochemistry validation performed on
134 samples. Compared to normal gastric tissue, the tumor tissues exhibited a significantly higher expression
level of TRPM8.

Conclusion:

This study provides insights into the underlying role of TRPM8 in cell proliferation. In
addition, TRPM8 may be used as a potential therapeutic target for patients with gastric cancer.
UBR5 Significantly Correlates with Osteosarcomas Prognosis and Immune
Exhaustion Characteristic in the Tumor Microenvironment
Authors: lin Hai , Zhang Liyan , Liu Bin , Cui Guopeng
Published: May 2023

Background:

Ubiquitin ligases (E3s) play an important role in multiple cancers.

Methods:

The open-accessed expression profile and clinical information was downloaded from the
TARGET database. The analysis was performed using R software.

Results:

In this study, we comprehensively investigated the role of E3s in osteosarcomas (OS). We
found that among all these E3s, UBR5 is a risk factor for OS. Considering that UBR5 has not been
reported in previous studies focused on OS, we selected it for further analysis. Interestingly, we found
that UBR5 had no significant effect on immune cell infiltration but a remarkable effect on immune
function. Moreover, we divided the patients into “immune activation” and “immune exhaustion”
types. KM survival curves indicated that the patients in the “immune exhaustion” types had a worse
survival performance.
Further, we identified the molecules involved in immune function and significantly correlated with
UBR5. The biological enrichment analysis and prognosis model were then conducted based on these
genes. Results indicated that the patients in the high-risk group had a worse survival performance, and
underlying biological differences between high and low-risk patients were also explored. Ultimately,
the effect pattern of UBR5 in pan-cancer was also explored.

Conclusion:

In summary, our study comprehensively explored the role of UBR5 in OS, as well as its
effect on the immune microenvironment, which might be an underlying therapy target.
WITHDRAWN: Research and Application in the Nanomedicines for Targeting Lung Diseases
Authors: Yu Yang , Liu Hui , Pei Yanmin , Xia Tian , Ma Ping , Xu Qingbin , Zhou Ru
Published: May 2023

The article has been withdrawn at the request of the authors of the journal Drug Metabolism and Bioanalysis Letters.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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Dialogue ou Diversion des Membres de L’Elite Leader en Afrique Francophone
Authors: Mohamed Bahdon Abdillahi
Published: May 2023

Dans le jeu politique d’un régime démocratique, le dialogue politique est un élément. Mais quand un consensus entre les différences forces politiques et sociales n’existe pas, il y a un dysfonctionnement institutionnel. Et on parle d’une crise politique. L’instauration d’un régime politique plural-iste sur le plan formel dans certains pays d’Afrique francophone n’a pas conduit forcément un régime où les règles du jeu politique et les droits et libertés fondamentales ne sont pas respectés par des pouvoirs encore au-toritaires et personnels. La longue durée d’un régime, qui s’est construit autour d’une personne et d’une équipe, conduit forcément à l’exclusion de toute force politique, qui conteste sa politique et le fonctionnement institu-tionnel qu’elle induit. A la différence des premiers régimes politiques, les nouveaux régimes autoritaires de ces pays développent une stratégie afin de surmonter la crise non pas sur le plan répressif, mais en recourant à une au-tre voie. Et c’est ainsi qu’ils organisent ce qu’on a appelé communément un dialogue avec quelques représentants de l’opposition. Il devient un moyen politique pour le pouvoir et l’opposition, politique et sociale. Mais selon le fonctionnement du régime en question, la convocation d’un dialogue peut être une simple diversion, plus destinée à ce qu’on appelle pompeusement les partenaires, c’est-à-dire aux pays occidentaux, qui les soutiennent.
Analysis of Community-Based Coffee Agro-tourism Sustainability in East Java, Indonesia
Authors: Hidayat Fajar , Hakim Luchman , Parmawati Rita
Published: May 2023

Agro-tourism is the potential sector that can be developed in rural areas for local economic enhancement, contributing to conservation, and awarding local wisdom. However, several problems in development cause agro-tourism not to be sustainable. This research aimed to describe the existing condition and assess the sustainability of coffee agro-tourism. We evaluate the existing condition and sustainability status by assessing ancillary, attractions, accessibility, amenities, economy, ecology and socio-culture. Respondents from this research were 141 respondents, and each respondent was interviewed with a questionnaire. Data analysis was conducted with two methods: descriptive analysis and MDS (Multidimensional Scaling). Existing conditions from the institutional aspect show that some agro-tourism does not have institutional legality, the main attraction is coffee plantations, accessibility is challenging to reach, amenities do not yet have quality according to standards, economic actors are the community, public perception of agro-tourism is very positive. MDS analysis status is very sustainable regarding economic aspects, with a score index of 76.82 %. Ecology, amenities, attractions, social culture and ancillary aspects show enough sustainable status with a score index of 71.01%, 67.73%, 67.59%, 67.58% and 59.97%. At the same time, the accessibility aspect shows a less sustainable status with an index of 33.49%. The results of the leverage analysis show 29 sensitive attributes are an influential key factor in sustainability.
Pola Konsumsi Pangan Penyandang Disabilitas di Kota Malang
Authors: Shinta Agustina
Published: May 2023

This research aims to (1) identify indicators of food and nutrition on people with disabilities, and (2) to analyze the pattern of diversification of persons with disabilities. Identification of indicators using the Recommended Daily Intake of energy, protein, fat, carbohydrates and Micronutrients (Ca, F, Fe and vitamin C), while the diversification pattern analysis method using the analysis of Dietary Pattern Hope. The results showed that (1) persons with disabilities in Malang meet the Recommended Daily Intake of energy, carbohydrates and Micronutrients for iron and phosphorus, but the excess in the Recommended Daily Intake of fat and deficient in the Recommended Daily Intake for protein, vitamin C and calcium; (2) persons with disabilities in Malang is in diversification in groups of oils and fats, but shortages in fish and sea food groups.