bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 1 from GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers
Authors: Sabbatini Peter , Korenchuk Susan , Rowand Jason L. , Groy Arthur , Liu Qi , Leperi Dominic , Atkins Charity , Dumble Melissa , Yang Jingsong , Anderson Kelly , Kruger Ryan G. , Gontarek Richard R. , Maksimchuk Kenneth R. , Suravajjala Sapna , Lapierre Russell R. , Shotwell J. Brad , Wilson Joseph W. , Chamberlain Stanley D. , Rabindran Sridhar K. , Kumar Rakesh
Published: April 2023

Supplementary Figure 1. Cell cycle effects of GSK1838705A.
Supplementary Data from Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
Authors: Holder Sheldon , Zemskova Marina , Zhang Chao , Tabrizizad Maryam , Bremer Ryan , Neidigh Jonathan W. , Lilly Michael B.
Published: April 2023

Supplementary Data from Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
Supplementary Figure and Table Legends 1-4 from Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells
Authors: Sun Feng , Chan Eli , Wu Zhenlong , Yang Xiaojing , Marquez Victor E. , Yu Qiang
Published: April 2023

Supplementary Figure and Table Legends 1-4 from Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells
Supplementary Figure 4 from Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells
Authors: Sun Feng , Chan Eli , Wu Zhenlong , Yang Xiaojing , Marquez Victor E. , Yu Qiang
Published: April 2023

Supplementary Figure 4 from Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells
Supplementary Fig. S1 from Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen
Authors: Ariazi Eric A. , Leitão Andrei , Oprea Tudor I. , Chen Bin , Louis Teresa , Bertucci Anne Marie , Sharma Catherine G.N. , Gill Shaun D. , Kim Helen R. , Shupp Heather A. , Pyle Jennifer R. , Madrack Alexis , Donato Anne L. , Cheng Dong , Paige James R. , Jordan V. Craig
Published: April 2023

Supplementary Fig. S1 from Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen
Supplementary Fig. S3 from EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line
Authors: Fukai Junya , Yokote Hideyuki , Yamanaka Ryuya , Arao Tokuzo , Nishio Kazuto , Itakura Toru
Published: April 2023

Supplementary Fig. S3 from EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line
Supplementary Table 1 from Sorafenib, a Multikinase Inhibitor, Enhances the Response of Melanoma to Regional Chemotherapy
Authors: Augustine Christina K. , Toshimitsu Hiroaki , Jung Sin-Ho , Zipfel Patricia A. , Yoo Jin S. , Yoshimoto Yasunori , Selim M. Angelica , Burchette James , Beasley Georgia M. , McMahon Nicole , Padussis James , Pruitt Scott K. , Ali-Osman Francis , Tyler Douglas S.
Published: April 2023

Supplementary Table 1 from Sorafenib, a Multikinase Inhibitor, Enhances the Response of Melanoma to Regional Chemotherapy
Supplementary Figure 3 from Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition
Authors: Breuleux Madlaina , Klopfenstein Matthieu , Stephan Christine , Doughty Cheryl A. , Barys Louise , Maira Saveur-Michel , Kwiatkowski David , Lane Heidi A.
Published: April 2023

Supplementary Figure 3 from Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition
Supplementary Fig. S6 from Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells
Authors: Weisberg Ellen , Wright Renee D. , McMillin Douglas W. , Mitsiades Constantine , Ray Arghya , Barrett Rosemary , Adamia Sophia , Stone Richard , Galinsky Ilene , Kung Andrew L. , Griffin James D.
Published: April 2023

Supplementary Fig. S6 from Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells
Supplementary Fig. S4 from Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells
Authors: Weisberg Ellen , Wright Renee D. , McMillin Douglas W. , Mitsiades Constantine , Ray Arghya , Barrett Rosemary , Adamia Sophia , Stone Richard , Galinsky Ilene , Kung Andrew L. , Griffin James D.
Published: April 2023

Supplementary Fig. S4 from Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells
Supplementary Fig. S3 from Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells
Authors: Weisberg Ellen , Wright Renee D. , McMillin Douglas W. , Mitsiades Constantine , Ray Arghya , Barrett Rosemary , Adamia Sophia , Stone Richard , Galinsky Ilene , Kung Andrew L. , Griffin James D.
Published: April 2023

Supplementary Fig. S3 from Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells
Supplementary Figures 1-4 from Integrative Analysis of Proteomic Signatures, Mutations, and Drug Responsiveness in the NCI 60 Cancer Cell Line Set
Authors: Park Eun Sung , Rabinovsky Rosalia , Carey Mark , Hennessy Bryan T. , Agarwal Roshan , Liu Wenbin , Ju Zhenlin , Deng Wanleng , Lu Yiling , Woo Hyun Goo , Kim Sang-Bae , Cheong Jae-Ho , Garraway Levi A. , Weinstein John N. , Mills Gordon B. , Lee Ju-Seog , Davies Michael A.
Published: April 2023

Supplementary Figures 1-4 from Integrative Analysis of Proteomic Signatures, Mutations, and Drug Responsiveness in the NCI 60 Cancer Cell Line Set
Supplementary Figure Legends 1-4 from Integrative Analysis of Proteomic Signatures, Mutations, and Drug Responsiveness in the NCI 60 Cancer Cell Line Set
Authors: Park Eun Sung , Rabinovsky Rosalia , Carey Mark , Hennessy Bryan T. , Agarwal Roshan , Liu Wenbin , Ju Zhenlin , Deng Wanleng , Lu Yiling , Woo Hyun Goo , Kim Sang-Bae , Cheong Jae-Ho , Garraway Levi A. , Weinstein John N. , Mills Gordon B. , Lee Ju-Seog , Davies Michael A.
Published: April 2023

Supplementary Figure Legends 1-4 from Integrative Analysis of Proteomic Signatures, Mutations, and Drug Responsiveness in the NCI 60 Cancer Cell Line Set
Supplementary Fig. S1 from In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies
Authors: Ogawa Mikako , Regino Celeste A.S. , Choyke Peter L. , Kobayashi Hisataka
Published: April 2023

Supplementary Fig. S1 from In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies
Supplementary Fig. S3 from Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis
Authors: Kaulfuβ Silke , Burfeind Peter , Gaedcke Jochen , Scharf Jens-Gerd
Published: April 2023

Supplementary Fig. S3 from Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis
Supplementary Table S4 from Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
Authors: Okabe Mitsunori , Szakács Gergely , Reimers Mark A. , Suzuki Toshihiro , Hall Matthew D. , Abe Takaaki , Weinstein John N. , Gottesman Michael M.
Published: April 2023

Supplementary Table S4 from Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
Supplementary Fig. S1 from Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
Authors: Okabe Mitsunori , Szakács Gergely , Reimers Mark A. , Suzuki Toshihiro , Hall Matthew D. , Abe Takaaki , Weinstein John N. , Gottesman Michael M.
Published: April 2023

Supplementary Fig. S1 from Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
Supplementary Table 2 from Reprogramming Murine Telomerase Rapidly Inhibits the Growth of Mouse Cancer Cells In vitro and In vivo
Authors: Xu Tong , Xu Yucheng , Liao Chun-Peng , Lau Roy , Goldkorn Amir
Published: April 2023

Supplementary Table 2 from Reprogramming Murine Telomerase Rapidly Inhibits the Growth of Mouse Cancer Cells In vitro and In vivo
Supplementary Fig. S3 from Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts
Authors: Messersmith Wells A. , Rajeshkumar N.V. , Tan Aik Choon , Wang Xiao Fei , Diesl Veronica , Choe Sung E. , Follettie Max , Coughlin Christina , Boschelli Frank , Garcia-Garcia Elena , Lopez-Rios Fernando , Jimeno Antonio , Hidalgo Manuel
Published: April 2023

Supplementary Fig. S3 from Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts
Supplementary Fig. S1 legend from Eps8 decreases chemosensitivity and affects survival of cervical cancer patients
Authors: Chen Yun-Ju , Shen Meng-Ru , Chen Yen-Jen , Maa Ming-Chei , Leu Tzeng-Horng
Published: April 2023

Supplementary Fig. S1 legend from Eps8 decreases chemosensitivity and affects survival of cervical cancer patients
Supplementary Figure from Small Interfering RNA Targeting 14-3-3ζ Increases Efficacy of Chemotherapeutic Agents in Head and Neck Cancer Cells
Authors: Matta Ajay , DeSouza Leroi V. , Ralhan Ranju , Siu K.W. Michael
Published: April 2023

Supplementary Figure from Small Interfering RNA Targeting 14-3-3ζ Increases Efficacy of Chemotherapeutic Agents in Head and Neck Cancer Cells
Supplementary Data from Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers
Authors: Komatsu Masaaki , Hiyama Keiko , Tanimoto Keiji , Yunokawa Mayu , Otani Keiko , Ohtaki Megu , Hiyama Eiso , Kigawa Junzo , Ohwada Michitaka , Suzuki Mitsuaki , Nagai Nobutaka , Kudo Yoshiki , Nishiyama Masahiko
Published: April 2023

Supplementary Data from Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers
Supplementary Fig. S2 from Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
Authors: Smalley Keiran S.M. , Haass Nikolas K. , Brafford Patricia A. , Lioni Mercedes , Flaherty Keith T. , Herlyn Meenhard
Published: April 2023

Supplementary Fig. S2 from Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
Development of a Device for Dynamic Simulation of the Breathing System to Evaluate a Functional Nonwoven Fabric Coated with Cu Film
Authors: Dapper Gabriel Justen , Frassini Rafaele , de Souza Wellington Vieira , Roesch-Ely Mariana , Figueroa Carlos Alejandro , Aguzzoli Cesar
Published: April 2023

One of the challenges to evaluate the performance of functional materials for face masks is to look for a dynamic interaction with biological samples. A device for dynamic simulation of breathing system is constructed and dynamic and static responses of a polypropylene (C3H6)n nonwoven fabric coated with Cu film by magnetron‐sputtering process, against Escherichia coli, are analyzed. The use of scanning electron microscopy, energy‐dispersive spectroscopy, and the 3‐4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) indirect method using the L929 mouse fibroblasts, and the procedure of Antibacterial Activity of Textile Materials: Parallel Streak (TM147) from American Association of Textile Chemists and Colorists (AATCC) using E. coli and Staphylococcus aureus strains, allows to evaluate the morphological, physicochemical, and biological static performance of the obtained composite. No leaching of the deposited Cu film in the substrate is observed after using the device for dynamic simulation of breathing system. The permeability coefficient of the nonwoven fabric is obtained, equivalent to 71.4 Pa cm−2. By the dynamic response against E. coli bacteria, the best bactericidal activity is observed for S960 with the maximum Cu concentration, presenting a high potential for application as a functional layer in facial masks.
Tribology in Warm and Hot Aluminum Sheet Forming: Transferability of Strip Drawing Tests to Forming Trials
Authors: Schell Lukas , Sellner Erik , Massold Michael , Groche Peter
Published: April 2023

For conventional sheet metal forming at room temperature, numerous tribometers have been developed in the 20th century. At the present state of the art, there are some challenges for tribometry in warm and hot forming processes of high‐strength aluminum (e.g., EN AW‐7075). Especially for nonisothermal processes with heated sheets and cooled dies, the tribological design is a major challenge, which needs to be addressed by investigations with adapted tribometers. Herein, the transferability of friction and wear behavior of three different lubricants and temperatures is investigated. Therefore, tribometer test results are compared with real forming trials in combination with thermomechanical finite element simulations. Both the behavior of different lubricant types and the characteristics of tool lubrication in sheet metal forming are discussed.
Designing Covalent Organic Framework‐Based Light‐Driven Microswimmers toward Therapeutic Applications
Authors: Sridhar Varun , Yildiz Erdost , Rodríguez‐Camargo Andrés , Lyu Xianglong , Yao Liang , Wrede Paul , Aghakhani Amirreza , Akolpoglu Birgul M. , Podjaski Filip , Lotsch Bettina V. , Sitti Metin
Published: April 2023

While micromachines with tailored functionalities enable therapeutic applications in biological environments, their controlled motion and targeted drug delivery in biological media require sophisticated designs for practical applications. Covalent organic frameworks (COFs), a new generation of crystalline and nanoporous polymers, offer new perspectives for light‐driven microswimmers in heterogeneous biological environments including intraocular fluids, thus setting the stage for biomedical applications such as retinal drug delivery. Two different types of COFs, uniformly spherical TABP‐PDA‐COF sub‐micrometer particles and texturally nanoporous, micrometer‐sized TpAzo‐COF particles are described and compared as light‐driven microrobots. They can be used as highly efficient visible‐light‐driven drug carriers in aqueous ionic and cellular media. Their absorption ranging down to red light enables phototaxis even in deeper and viscous biological media, while the organic nature of COFs ensures their biocompatibility. Their inherently porous structures with ≈2.6  and ≈3.4 nm pores, and large surface areas allow for targeted and efficient drug loading even for insoluble drugs, which can be released on demand. Additionally, indocyanine green (ICG) dye loading in the pores enables photoacoustic imaging, optical coherence tomography, and hyperthermia in operando conditions. This real‐time visualization of the drug‐loaded COF microswimmers enables unique insights into the action of photoactive porous drug carriers for therapeutic applications.
Firms' profitability and ESG score: A machine learning approach
Authors: D'Amato Valeria , D'Ecclesia Rita , Levantesi Susanna
Published: April 2023

Corporate social responsibility (CSR) is found to impact firms' performance, for instance, enhancing reputation, increasing innovation capabilities, customer loyalty, and customer satisfaction help improve financial performance. However, the literature provides limited evidence of the relationship between CSR indicators, such as the ESG score, and the firm's profitability, which is often measured by the earnings before interest and taxes (EBIT). We investigate this issue by analyzing a sample of about 400 companies constituting the EuroStoxx‐600 index, from 2011 to 2020, using different machine learning models. The novelty of our contribution lies in assessing whether the ESG score has a significant influence on the firms' profitability. Specifically, we investigate the relationship between ESG score and EBIT using machine learning interpretability toolboxes such as partial dependence plots and individual conditional expectation. Tools which help to measure the functional relationship between the predicted response and one or more features, while the Shapley value allows to examine the contribution of the feature to the prediction. Our findings show that the model can reach high levels of accuracy in detecting EBIT and that the ESG score is a promising predictor, compared to other traditional accounting variables.
A case report: Diagnosis and treatment of idiopathic hypertrophic pachymeningitis
Authors: Luo Zhong , Cao Piao , Xu Jing‐Qing , Yan Rong , Wang Jian , Liang Tao , Chen Ya , Xu Zu‐Cai
Published: April 2023

A 57‐year‐old man who suffered from a headache for 1 year, accompanied by blurred vision for 7 months and numbness in his left face for 1 week was admitted to the Affiliated Hospital of Zunyi Medical University on May 7, 2022. One year ago, the patient had no obvious precipitating factor of paroxysmal stabbing pain in the whole skull with dizziness, which could be relieved by oneself after lasting for 1–2 min each time, with about 20 episodes per day. The cranial magnetic resonance imaging revealed changes in bilateral frontal lobe ischemic foci, bilateral frontal, ethmoid, sphenoid and maxillary sinusitis, and retinal macular degeneration. After hormone shock treatment, the condition improved. He suffered from headaches again with blurred vision in the right eye 7 months ago and was initially diagnosed with multiple sclerosis. He then was discharged after improvement due to hormone shock therapy. Oral hormone therapy was continued outside the hospital, but he stopped it due to drug side effects (details remained unclear). After cutting off, he developed a headache and visited our hospital once more, the relevant tests were performed and the patient was diagnosed with idiopathic hypertrophic pachymeningitis (IHP). The symptoms were slightly abated after hormone therapy. We hope that through this case report, we can deepen the clinicians' understanding of IHP, and improve the diagnosis rate of the disease through relevant examinations in future clinical work, so that patients can receive timely treatment and the mental pressure and economic burden caused by the disease on patients are reduced.
Determination of the erythrocyte sedimentation rate using the hematocrit‐corrected aggregation index and mean corpuscular volume
Authors: Higuchi Makoto , Watanabe Nobuo
Published: April 2023

Background

Determination of the erythrocyte sedimentation rate (ESR) by measurement of erythrocyte aggregation is an alternative to the Westergren method and can be performed rapidly. However, its principle is opaque and the ESR values obtained can deviate from Westergren method values (WG ESR) due to hematocrit. Furthermore, WG ESR is affected by particle size, but no studies have examined the effect of individual mean corpuscular volumes (MCVs).

Methods

Simultaneous measurement of the erythrocyte aggregation index (AI) over a 5‐s interval and determination of the complete blood count in 80 μL blood from 203 patients were performed (hematocrit, 21.4%–52.3%; MCV, 62.7–114.1 fL). ESR values were calculated with the hematocrit‐corrected AI (HAI) for comparison with WG ESR. We improved the calculation formula by using MCV.

Results

The sedimentation velocity of a single erythrocyte in the samples agreed well with an exponential function of HAI. ESR values calculated using HAI showed excellent correlation with WG ESR (r = 0.899, p < 0.001; Bland–Altman analysis: bias 2.76, limits of agreement (LOA) −24.5 to 30.0), but the difference between the calculated ESR and WG ESR increased with decreasing MCV. Calculation of ESR considering both HAI and MCV eliminated the MCV‐dependent deviation and improved the correlation with WG ESR (r = 0.920, p < 0.001, bias −2.17, LOA −24.6 to 20.3).

Conclusion

Calculation using HAI and MCV can rapidly provide ESR values that are highly correlated with WG ESR in clinical specimens over a wide range of hematocrit and MCV values.
“The lab isn't life”: Black engineering graduate students reprioritize values at the intersection of two pandemics
Authors: Coley Brooke , Thomas Katreena
Published: April 2023

Background

Black engineering graduate students represent a critical and understudied population in engineering education. Gaining an understanding of the lived experiences of Black engineering graduate students while they are simultaneously weathering two pandemics, COVID‐19 and systemic racism, is of paramount importance.

Purpose/Hypothesis

Black engineering graduate students hold a unique duality, as both Black people in the United States and Black graduate students in US engineering programs that espouse white supremacist ideals. Their real‐world experiences necessitate understanding, and this paper highlights the related impact on the students themselves, their adaptations to the pandemics, and how those adaptations relate to and affect their support needs and navigation of their engineering academic environments.

Design/Method

An interpretive phenomenological analysis (IPA) approach was combined with community‐based participatory action research and was situated in Boykin's Triple Quandary. A family check‐in was conducted with 10 Black engineering graduate students enrolled in doctoral programs across the country to delve deep into their lived experience as a cultural community.

Results

Findings include an emergent framework of Black engineering graduate student values in response to the pandemics. These values aligned with the Black Cultural Ethos, demonstrating an adoption of collectivistic cultural values in times of crises. Further, COVID‐19 and systemic racism differentially impacted Black engineering graduate students and, thus, the manifestations of their values.

Conclusion

For institutions to be able to effectively support their Black engineering graduate students, they must gain awareness of the students' experiences, values, and needs, in general, and amid crises specifically. The findings presented here provide a critical window into this information.
Lidocaine–epinephrine–tetracaine（LET）を使用した小児の創傷処理に関する記述的研究(A case series of anaesthetic efficacy of lidocaine, epinephrine, and tetracaine (LET) for wound management in children)
Authors: 和喜 伊丹 , 啓子 内藤 , 隆太 小野寺 , 仁 髙橋 , 拓 舩越
Published: April 2023

【目的】Lidocaine–epinephrine–tetracaine（LET）は，多くは小児における創傷処理の表面麻酔に使用されている。LETはリドカインの局所注射麻酔と比較しても効果に遜色がないことが示されているが，本邦におけるLETを使用した創傷処理に関する報告は限られている。そこで当院救急外来におけるLETを使用した小児の創傷処理の現状と有効性，副作用に関して調査した。【対象】本報告はカルテレビューに基づく単施設記述研究である。2018年4月1日から2021年3月31日までの期間に当院救急外来を受診した15歳以下の患者で，LETを使用し創傷処理を行った患者群を対象とした。調査項目は年齢，性別，創部の長さ，部位，局所注射麻酔もしくは鎮静鎮痛（procedural sedation and analgesia: PSA）の追加の有無，有害事象の有無とした。【結果】対象患者は312人で，LETのみで創傷処理を完遂できた症例は262例（84%），LETと局所注射麻酔を併用した症例は35例（11%），LETとPSAを併用した症例は10例（3%），LET，局所注射麻酔，PSAを併用した症例は5例（2%）であった。本報告において有害事象は0例（0%）であった。【結語】LETでの創傷処理は適切な鎮痛効果かつ少ない有害事象で施行可能と考えられる。
相対的適応で実施した血液透析で致死量摂取のアスピリン中毒を治療した1例(A case of successful treatment with hemodialysis after ingestion of a lethal dose of aspirin)
Authors: 元太 竹村 , 嗣明 寺島 , すばる 田邊 , 大 大石 , 祐史 久下 , 雅庸 津田
Published: April 2023

服毒自殺目的に大量摂取されたアスピリン［アセチルサリチル酸（acetylsalicylic acid: ASA）］が通常の半減期を大幅に延長していたが，血液透析により著明な症状改善を得た1例を経験したため，若干の考察とともに報告する。症例は20歳の男性，2日間にわたりASAを過量摂取（各13.2g，26.4g）し，発熱などを主訴に2回目の摂取から約8時間経過して救急外来を受診した。来院時は頻呼吸・頻脈・耳鳴症状を認め，活性炭投与，大量補液，アルカリ化利尿などの保存的治療を行ったが，症状改善に乏しく，難聴の出現，呼吸性アルカローシスと凝固機能の悪化を認めたためsalicylic acid（SA）の除去目的に血液透析を行った。初回および再検査の血中SA濃度から半減期が20.3時間と過延長していたが，2回の血液透析により，自覚症状の改善と採血結果の改善を認め，第7病日に聴力検査したところ感音難聴は改善した。中毒学的には2回目のみで考えても致死的の517mg/kgを摂取，予測最高血中濃度は1,045μg/mLと重症例であったが，血液透析により速やかな血中濃度減少を認め，有効な治療であったと考えられる。
Sleep and its variability in relation to behavioral outcomes in school‐age children with overweight and obesity
Authors: Tsai Shao‐Yu , Tung Yi‐Ching , Huang Chuen‐Min , Lee Chien‐Chang
Published: April 2023

This was a cross‐sectional study to examine sleep and its variability in relation to behavioral outcomes in school‐age children with overweight and obesity. A total of 246 school‐age children with overweight or obesity were recruited between 2019 and 2021 from 10 public elementary schools in Northern Taiwan. Parents completed sleep and behavior questionnaires, with children wearing an actigraphy monitor for 7 days. Average daily sleep duration by actigraphy was 7.52 h, with 84.6% of the children having clinically significant sleep disturbance scores and 68.3% having a total behavior problem score in the clinical range. Children were categorized by median split for sleep duration and sleep duration variability. Multivariate regression analyses showed that children in the insufficient (duration)‐stable (variability) sleep category had significantly higher scores for emotion problems (B = 0.94, p = 0.01), self‐control problems (B = 1.61, p < 0.01), and total behavior problems (B = 3.38, p < 0.01) compared to children in the sufficient‐stable sleep (reference) category. Children in the insufficient‐variable sleep category had significantly higher self‐control problem scores compared to children in the reference category (B = 1.03, p < 0.05). Findings from our study suggest that school‐age children with overweight and obesity coexist with sleep and behavioral problems, and those who have consistently insufficient sleep are at the greatest risk for the worst behavioral outcomes. Screening for sleep habits and behavioral problems should be considered a standard practice in pediatric overweight and obesity.
Flavonstrahlung in the B3 − L2 Z′ model at current and future colliders
Authors: Allanach Ben , Loisa Eetu
Published: April 2023

Abstract

The B3− L2Z′ model may explain some gross features of the fermion mass spectrum as well as b → sℓℓ anomalies. A TeV-scale physical scalar field associated with gauged $$ U{(1)}_{B_3-{L}_2} $$
U

1

B
3

−

L
2

spontaneous symmetry breaking, the flavon field ϑ, affects Higgs phenomenology via mixing. In this paper, we investigate the collider phenomenology of the flavon field. Higgs and W boson mass data are used to place bounds upon parameter space. We then examine flavonstrahlung (Z′ → Z′ϑ production) at colliders as a means to directly produce and discover flavon particles, which would provide direct empirical evidence tying the flavon to $$ U{(1)}_{B_3-{L}_2} $$
U

1

B
3

−

L
2

symmetry breaking. A 100 TeV FCC-hh or a 10 TeV muon collider would have high sensitivity to flavonstrahlung, whereas the HL-LHC can observe it only in extreme corners of parameter space.
Permutation tests for experimental data
Authors: Holt Charles A. , Sullivan Sean P.
Published: April 2023

This article surveys the use of nonparametric permutation tests for analyzing experimental data. The permutation approach, which involves randomizing or permuting features of the observed data, is a flexible way to draw statistical inferences in common experimental settings. It is particularly valuable when few independent observations are available, a frequent occurrence in controlled experiments in economics and other social sciences. The permutation method constitutes a comprehensive approach to statistical inference. In two-treatment testing, permutation concepts underlie popular rank-based tests, like the Wilcoxon and Mann–Whitney tests. But permutation reasoning is not limited to ordinal contexts. Analogous tests can be constructed from the permutation of measured observations—as opposed to rank-transformed observations—and we argue that these tests should often be preferred. Permutation tests can also be used with multiple treatments, with ordered hypothesized effects, and with complex data-structures, such as hypothesis testing in the presence of nuisance variables. Drawing examples from the experimental economics literature, we illustrate how permutation testing solves common challenges. Our aim is to help experimenters move beyond the handful of overused tests in play today and to instead see permutation testing as a flexible framework for statistical inference.
Birch establishes anywhere! So, what is there to know about natural regeneration and direct seeding of birch?
Authors: Lidman Felicia Dahlgren , Karlsson Matts , Lundmark Tomas , Sängstuvall Lars , Holmström Emma
Published: April 2023

We tested three soil scarification approaches of varying intensity (intensive preparation exposing bare mineral soil, medium intensity with a mixture of organic material and mineral soil, and control without site preparation) on six clear-felled sites in two localities in northern and central Sweden between 2018 and 2021. The effect of soil scarification intensity and soil moisture on the occurrence of naturally regenerated birch seedlings was tested one, two and three years after soil scarification, and the density of direct-seeded birch seedlings one year after seeding. In addition, we tested the effect of the annual seed rain, and differences between the two birch species, on the density of direct-seeded seedlings. Soil scarification and its interaction with soil moisture had a significant positive effect on both the occurrence of naturally regenerated birch seedlings and the density of direct-seeded birch seedlings. There was no significant effect of neither annual natural seed rain nor species choice on direct-seeded seedling density. Time since soil scarification had a significant effect on the occurrence of naturally regenerated birch seedlings. In moist soils with high volumetric water content (≥ 28%), birch seeds germinate at high rates and seedlings survive without soil scarification. In mesic soils, birch seeds germinate with higher rates after soil scarification. In dry soils, birch seeds rarely germinate regardless of any disturbance of the humus layer.
Numerical study of a plasma jet for plasma-assisted laser cutting
Authors: Manzke Sebastian , Krümmer Moritz , Urlau Franz , Mahrle Achim , Füssel Uwe , Leyens Christoph
Published: April 2023

Laser fusion cutting commonly applies a high-pressurized nitrogen gas jet to blow the molten material out of the cut kerf. However, theoretical considerations suggest that the use of a plasma jet may offer some advantages over this conventional approach. In this preliminary investigation, the characteristics of a non-transferred plasma jet for the application as auxiliary gas in laser beam cutting are analyzed using numerical CFD simulation. Based on this study, a first prototype of a plasma jet generator was manufactured and used in initial cutting experiments on 6 mm thick AISI 304 stainless steel. Two different cooling concepts for the plasma torch were considered and investigated in practice. Suitable values for the nozzle exit diameter, the distance between the electrodes of the plasma torch, the auxiliary gas flow rate and the electric current were identified both model-based and experimentally. The achieved cutting performance is considered a proof-of-principle of the suggested approach of a plasma-assisted laser beam cutting process.
AdaLiftOver: high-resolution identification of orthologous regulatory elements with Adaptive liftOver
Authors: Dong Chenyang , Shen Siqi , Keleş Sündüz
Published: April 2023

Motivation

Elucidating functionally similar orthologous regulatory regions for human and model organism genomes is critical for exploiting model organism research and advancing our understanding of results from genome-wide association studies (GWAS). Sequence conservation is the de facto approach for finding orthologous non-coding regions between human and model organism genomes. However, existing methods for mapping non-coding genomic regions across species are challenged by the multi-mapping, low precision, and low mapping rate issues.

Results

We develop Adaptive liftOver (AdaLiftOver), a large-scale computational tool for identifying functionally similar orthologous non-coding regions across species. AdaLiftOver builds on the UCSC liftOver framework to extend the query regions and prioritizes the resulting candidate target regions based on the conservation of the epigenomic and the sequence grammar features. Evaluations of AdaLiftOver with multiple case studies, spanning both genomic intervals from epigenome datasets across a wide range of model organisms and GWAS SNPs, yield AdaLiftOver as a versatile method for deriving hard-to-obtain human epigenome datasets as well as reliably identifying orthologous loci for GWAS SNPs.

Availability and implementation

The R package and the data for AdaLiftOver is available from https://github.com/keleslab/AdaLiftOver.
The Joint Investigation Team in Ukraine: An Opportunity for the International Criminal Court?
Authors: Tan Yudan , Yang Suhong
Published: April 2023

During the 2022 Russia-Ukraine war, a joint investigation team (JIT) with members of seven States and a participant from the Office of the Prosecutor (OTP) of the International Criminal Court (ICC) was set up on alleged core international crimes committed in Ukraine. It is an unprecedented development that the OTP joins a JIT with national authorities under the auspices of the European Union Agency for Criminal Justice Cooperation (Eurojust). This essay analyses how the OTP’s participation in the JIT in Ukraine may affect the proactive complementarity of the ICC. It identifies the benefits of a JIT tool and the potential consequences of the OTP’s engagement in a JIT for its independence and impartiality. It argues that despite concerns and challenges, the OTP’s participation in a JIT offers a novel modality of implementing the policy of proactive complementarity through two-track cooperation and assistance.
Development and Validation of the Glasgow Exclusive Enteral Nutrition Index of Compliance
Authors: Jatkowska Aleksandra , White Bernadette , Nichols Ben , Svolos Vaios , Gkikas Konstantinos , Hansen Richard , Russell Richard K , Gaya Daniel , Brownson Emily , Seenan John Paul , Milling Simon , MacDonald Jonathan , Gerasimidis Konstantinos
Published: April 2023

Background and Aims

Treatment adherence is key to the efficacy of exclusive enteral nutrition [100% EN] in active Crohn’s disease [CD], but there are no biomarkers to objectively estimate this. We explored faecal parameters as biomarkers of compliance with 100% EN, and subsequently developed and validated the Glasgow Exclusive Enteral Nutrition Index of Compliance [GENIE].

Methods

Healthy adults replaced all [100% EN] or part [85% EN, 50% EN, 20% EN] of their diet with a formula for 7 days. Faecal pH, water content, short chain fatty acids, and branched chain fatty acids [BCFAs] were measured before [D0] and after [D7] each intervention. Optimal biomarkers and threshold values were derived using receiver operating characteristic curve analyses and machine learning to develop the GENIE. The GENIE was then validated in 30 CD children, during and after 100% EN.

Results

In all, 61 adults were recruited. D7 faecal pH and the ratios of BCFAs to either acetate or butyrate performed the best to differentiate between patients on 100% EN from <100% EN. Two models were generated; one included faecal metabolites (Laboratory GENIE, L-GENIE; sensitivity, specificity, and positive predictive value [PPV] of 88%, 94%, and 92%) and a second one [Clinical Genie, C-GENIE] which considers only faecal pH [sensitivity, specificity, and PPV of 84%, 86%, and 81%]. Validation of GENIE in CD children found that C-GENIE outperformed L-GENIE, producing a sensitivity, specificity, and PPV of 85%, 88%, and 88%, respectively.

Conclusions

GENIE can help predict adherence to 100% EN and may complement current conventional dietary assessment.
Bilinear Integrable soliton solutions and carbon emission rights pricing
Authors: Yang Xing , Mi Jun-long , Zeng Yue , Wei Wen-bo
Published: April 2023

Pricing carbon emission rights and other financial assets using the soliton theory is a pioneering attempt. In this study, we investigated the pricing of carbon emission rights according to the basic attributes of solitons, whose amplitude and velocity remain unchanged after a collision. First, we showed that the price fluctuation in the sequence of carbon emission rights possesses the characteristics of a soliton, such as non-dispersion while spreading and being stable after a collision. With a variation in the time scale, the waveform and velocity of the carbon price movement did not change with its translation in the same direction. Second, we demonstrated that the carbon soliton equation passes the $Painlev\acute{e}$ test for integrability. Moreover, at the resonance point, there exists an arbitrary function ${u}_j(t)$ of $t$ in which the compatibility condition always holds. This indicates the existence of soliton solutions to the carbon soliton equation. Third, the exact solutions of single-soliton, two-soliton and three-soliton equations were obtained by using a nonlinear evolution equation constructed with a bilinear method. In the three soliton solutions, only the single-soliton solution is the central value of the carbon emission rights and its theoretical value is 13 Euro/tCO2e.
Duration of ergovaline exposure influences serotonin-mediated vasoactivity of bovine mesenteric vasculature
Authors: Trotta Ronald J , Harmon David L , Ji Huihua , Klotz James L
Published: April 2023

Ergovaline (ERV), produced in toxic endophyte-infected tall fescue, causes potent vasoconstriction of bovine peripheral and visceral vasculature. Ergovaline acts as both an agonist and an antagonist in bovine gut blood vessels through serotonin (5-HT) receptors and it appears that the type of action could be influenced by the extent of ERV exposure. Because it was unclear how the duration of ERV exposure influences 5-HT-mediated vasoactivity, experiments were designed to evaluate how simultaneous or prior ERV exposure influenced 5-HT-mediated vasoactivity of mesenteric artery (MA) and vein (MV) segments from Holstein steers (N = 10). Vessels were incubated in Krebs–Henseleit buffer containing 0, 0.01, or 0.1 μM ERV for 24 h prior to the 5-HT dose-response or exposed to fixed concentrations of 0, 0.01, or 0.1 μM ERV simultaneously during the 5-HT dose-response. Vessels were suspended in chambers of a multimyograph containing Krebs–Henseleit buffer and equilibrated to 1 g tension for 90 min. Vessels were exposed to increasing concentrations of 5-HT (5 × 10−8 M to 1 × 10−4 M) every 15 min and contractile responses were normalized as a percentage of the maximum contractile response induced by 120 mM KCl reference addition. Two-way analysis of variance was used to separately analyze data for each vessel type and duration of exposure using the MIXED procedure of SAS. When 5-HT concentration increased from 5 × 10−8 to 1 × 10−6 M, simultaneous addition of 0.1 μM ERV increased (P < 0.01) the contractile response of MV compared with additions of 0 and 0.01 μM ERV. At 1 × 10−4 M 5-HT, the simultaneous presence of 0.01 and 0.1 μM ERV decreased (P < 0.01) the contractile response of both MA and MV compared with 0 μM ERV addition. As 5-HT concentrations increased, the contractile response increased (P < 0.01) in both MA and MV with no previous ERV exposure, but decreased in MA and MV with 24 h prior exposure to 0.01 and 0.1 μM ERV. These data demonstrate that the duration of ERV exposure influences 5-HT-mediated vasoconstriction and likely vasorelaxation in bovine mesenteric vasculature. If ERV and 5-HT exposure occur simultaneously, ERV can act as a partial agonist of 5-HT-mediated vasoconstriction. If 5-HT exposure occurs after blood vessels have had prior ERV exposure, it appears that 5-HT may induce vasorelaxation of blood vessels. More research is needed to identify cellular and molecular mechanisms involved with 5-HT-mediated vasoactivity.
Predation and parasitism of naturally occurring and sentinel stink bug egg masses ofHalyomorpha halys(Stål) andNezara viridula(L.) (Hemiptera: Pentatomidae) in various southeastern habitats
Authors: Tillman P Glynn , Grabarczyk Erin E , Balusu Rammohan , Kesheimer Katelyn , Blaauw Brett , Sial Ashfaq , Vinson Edgar , Cottrell Ted E
Published: April 2023

Stink bugs, including Halyomorpha halys (Stål) and Nezara viridula (L.), are agricultural pests that feed on fruit in a variety of crops. Monitoring predation and parasitism of stink bug egg masses furthers our understanding of potential biological control tactics. However, best practices for laboratory and field assessments of parasitism and predation of egg masses require further attention. We carried out a series of laboratory and field experiments to test whether parasitism and predation for three types of sentinel H. halys egg masses, fresh, frozen, and refrigerated, varied in agricultural commodities. In addition, we asked if predation and parasitism differed between sentinel and naturally occurring H. halys and N. viridula egg masses in soybean. In the laboratory, more H. halys eggs were parasitized by Trissolcus euschisti (Ashmead) (Hymenoptera: Scelionidae) if they were frozen or refrigerated compared to fresh eggs. Similarly, in the field, parasitism was higher for frozen egg masses than fresh. In 2018 and 2019, H. halys natural egg masses had higher parasitism and lower predation compared to sentinel egg masses in soybean. In a paired field test during 2020 and 2021, there was no difference in parasitism between H. halys natural and sentinel eggs, but much higher incidence of parasitism was detected in natural N. viridula egg masses than sentinel eggs. Collecting natural egg masses is the best methodology for field assessment of parasitism of stink bug egg masses; however, if natural egg masses are not easily available, deploying refrigerated sentinel egg masses is a good alternative.
Early C-reactive protein kinetics predicts immunotherapy response in non-small cell lung cancer in the phase III OAK trial
Authors: Saal Jonas , Bald Tobias , Eckstein Markus , Ritter Manuel , Brossart Peter , Ellinger Jörg , Hölzel Michael , Klümper Niklas
Published: April 2023

Static biomarkers like programmed death-ligand 1 (PD-L1) are insufficient to accurately predict response to immune checkpoint inhibition. Therefore, on-treatment biomarkers, which measure immediate therapy-associated changes, are currently shifting into the focus of immuno-oncology. A prime example of a simple predictive on-treatment biomarker is the early C-reactive protein (CRP) kinetics with its predictive CRP flare-response phenomenon. Here, we were able to confirm the predictive value of CRP flare-response kinetics in the pivotal phase III OAK trial (NCT02008227), which compared atezolizumab with docetaxel in patients with non-small cell lung cancer. Of note, CRP flare-response predicted favorable outcomes only in the immune checkpoint inhibition–treated subgroup, which suggests that it is an immunotherapy-specific phenomenon. In conclusion, we have for the first time validated the high predictive value of early CRP kinetics in a pivotal phase III trial, justifying the broad use of this cost-effective and easy-to-implement on-treatment biomarker to optimize therapy monitoring for patients with non-small cell lung cancer.
Management of low colorectal anastomotic leakage using negative pressure therapy with Transanal Minimally Invasive Surgery (TAMIS): description of a case and review of the literature
Authors: Pende Vito , Fiori Giulia , Lucandri Giorgio , Genualdo Flaminia , Lucchese Sara , Falbo Francesco , Biancucci Andrea , Mazzocchi Paolo , Farina Massimo , Santoro Emanuele
Published: April 2023

Anastomotic leakage (AL) represents a major post-operative complication after low anterior resection (LAR) for rectal cancer. It is associated with increased morbidity, mortality, length of hospital stay and risk of permanent stoma. Herein we report the case of a 75-year-old male patient submitted to a minimally invasive LAR who developed an AL on the fifth post-operative day. This complication has been successfully managed by placing a Vacuum-Assisted Therapy device (Endo-SPONGE®) with an unusual Transanal Minimally Invasive Surgery (TAMIS) approach; the size of the abscess cavity was measured and the Endo-SPONGE® was cut according to the size of the fistulous defect. This procedure has been performed at regular intervals, achieving quick reduction of anastomotic defect. After the discharge from our department, the patient was addressed to adjuvant treatment. TAMIS may represent an alternative to the endoscopic approach to position an Endo-SPONGE® whenever a conservative management of an AL is required.
Ethanol root extract and fractions of Sphenocentrum jollyanum abrogate hyperglycaemia and low body weight in streptozotocin-induced diabetic Wistar albino rats
Authors: Ugwu Okechukwu Paul-Chima , Alum Esther Ugo , Okon Michael Ben , Aja Patrick M , Obeagu Emmanuel Ifeanyi , Onyeneke E C
Published: April 2023

Objectives

Effects of ethanol root extract and fractions of Sphenocentrum jollyanum on fasting blood glucose and body weight of streptozotocin-induced diabetic albino rats were carried.

Methods

Forty-eight rats were randomly assigned into eight groups. Groups 1 and 2 were diabetic rats treated with 0.5 ml of normal saline and 0.5 mg/kg b.w of glibenclamide, respectively while group 3 were non-diabetic rats treated with 0.5 ml of normal saline. Groups 4, 5 and 6 rats were diabetic rats treated with 250, 500 and 1 000 mg/kg b.w of extract, respectively, while rats in groups 7 and 8 were diabetic rats treated with 250 mg/kg b.w of methanol and ethylacetate fractions of S. jollyanum, respectively. Diabetes was induced by intraperitoneal injection of a single dose of 70 mg/kg b.w of streptozotocin. Fasting blood glucose levels were determined with glucometer.

Key findings

Treatment of diabetic rats with the extract and fractions of S. jollyanum at varied doses significantly (P < 0.05) decreased glucose level in a dose- and time-dependent manner. There was an increase in body weights of rats during treatment.

Conclusion

The extract and fractions lowered glucose levels and raised body weights of diabetic rats. This suggests that S. jollyanum possess antidiabetic property and could be useful in the management of diabetes.
Stochastic modeling of a gene regulatory network driving B cell development in germinal centers
Authors: Koshkin Alexey , Herbach Ulysse , Martínez María Rodríguez , Gandrillon Olivier , Crauste Fabien
Published: April 2023

Germinal centers (GCs) are the key histological structures of the adaptive immune system, responsible for the development and selection of B cells producing high-affinity antibodies against antigens. Due to their level of complexity, unexpected malfunctioning may lead to a range of pathologies, including various malignant formations. One promising way to improve the understanding of malignant transformation is to study the underlying gene regulatory networks (GRNs) associated with cell development and differentiation. Evaluation and inference of the GRN structure from gene expression data is a challenging task in systems biology: recent achievements in single-cell (SC) transcriptomics allow the generation of SC gene expression data, which can be used to sharpen the knowledge on GRN structure. In order to understand whether a particular network of three key gene regulators (BCL6, IRF4, BLIMP1), influenced by two external stimuli signals (surface receptors BCR and CD40), is able to describe GC B cell differentiation, we used a stochastic model to fit SC transcriptomic data from a human lymphoid organ dataset. The model is defined mathematically as a piecewise-deterministic Markov process. We showed that after parameter tuning, the model qualitatively recapitulates mRNA distributions corresponding to GC and plasmablast stages of B cell differentiation. Thus, the model can assist in validating the GRN structure and, in the future, could lead to better understanding of the different types of dysfunction of the regulatory mechanisms.