bluuebunny/crossref_metadata_2025 huggingface dataset:
Preoperative computed tomography-determined sarcopenia is a reliable prognostic factor in patients with gastric cancer after radical gastrectomy: A sex-specific analysis
Authors: Liu Ting , Yi Xiaoping , Ge Jie , Zhang Jinwei , Tan Fengbo , Song Kun , Liu Heli , Tang Mimi
Published: October 2022

Background

The predictive role of sarcopenia in cancer prognosis is an area of increasing concern. However, the influence of sex difference on the predictive role of sarcopenia in cancer prognosis has not been clearly defined. This retrospective cohort study investigated the effect of preoperative sarcopenia on the long-term outcomes of patients with gastric cancer (GC) based on sexual dimorphism.

Methods

Preoperative abdominal computed tomography (CT) scans from 379 GC patients who underwent radical gastrectomy were carefully analyzed. The patients were categorized into sarcopenia and non-sarcopenia groups according to the L3 skeletal muscle index (L3 SMI) measured on CT scans. Moreover, other indexes which can be used to evaluate the muscle area or the muscle quality, including skeletal muscle area (SMA), visceral fat area (VFA), subcutaneous fat area (SFA), skeletal muscle radiation attenuation (SM-RA), visceral fat index (VFI), subcutaneous fat index (SFI), and subcutaneous and visceral ratio (SV), were obtained from CT scans.

Results

There were 254 men and 125 women included in our study. After calculation, we defined sex-specific SMI-related mortality cutoff as 39.73 and 32.97 cm2/m2 for men and women. Univariable analysis showed that pathological tumor-node-metastasis (pTNM), depth of invasion, lymph node metastasis, differentiation degree, preoperative sarcopenia (for men), SMA (for men), L3 SMI, SFA (for women), SFI (for women), SV (for women), and SM-RA (especially for men) were significant independent predictors of overall survival (OS). Multivariable analysis showed that pTNM, depth of invasion, poor differentiation, and SM-RA were significantly associated with 5-year OS in GC patients. However, CT-determined sarcopenia was associated with significantly worse OS only in men, and SFA was significantly associated with 5-year OS only in women.

Conclusion

SM-RA is a reliable prognostic factor in patients with GC after radical gastrectomy. The impact of indexes mentioned above on survival outcomes is dependent on sex. CT-determined preoperative sarcopenia, a muscle-related indicator, was associated with outcomes in men. Adipose-related indicator (SFA), instead, was associated with outcomes in women.
Endometrial clear cell carcinoma: A population-based study
Authors: Cui Pengfei , Cong Xiaofeng , Zhang Youhao , Zhang Huimin , Liu Ziling
Published: October 2022

Background

A systematic analysis of prognostic factors concerning endometrial clear cell carcinoma (ECCC) is lacking. The current study aimed to construct nomograms predicting the overall survival (OS) of ECCC patients.

Methods

We performed a retrospective study, and predicted nomograms for 3-, 5-, and 10-year OS were established. The nomograms were verified with the consistency index (C-index), calibration curve, and decision curve analysis (DCA).

Results

A total of 1778 ECCC patients, 991 from FIGO stage I/II and 787 from FIGO stage III/IV, were included in this study. The age at diagnosis, marital status, T stage, tumor size, and surgery-independent prognostic factors in FIGO stage I/II, and the age at diagnosis, T stage, lymph node involvement, distant metastasis, tumor size, surgery, radiotherapy, and chemotherapy in FIGO stage III/IV were independent prognostic factors. The C-indexes of the training and validation group were 0.766 and 0.697 for FIGO stage I/II and 0.721 and 0.708 for FIGO stage III/IV, respectively. The calibration curve revealed good agreement between nomogram-predicted and actual observation values. The DCA established that nomograms had better clinical benefits than the traditional FIGO stage.

Conclusions

The predicted nomograms showed good accuracy, excellent discrimination ability, and clinical benefits, depicting their usage in clinical practice.
Case Report: A case of advanced duodenal adenocarcinoma in complete remission after chemotherapy combined with targeted therapy and radiotherapy
Authors: Zhang Zhengfeng , Lei Yang , Wang Dazhen , Yang Liu , Lou Changjie
Published: October 2022

Duodenal adenocarcinoma (DA) is an extremely rare and highly aggressive malignant tumor of the digestive system. Due to the lack of specific clinical characteristics, it is easy to misdiagnosis and miss diagnosis, and the lack of specific consensus and recommendation for treatment, so it often refers to stomach cancer and colorectal cancer. Now, we report a case of a patient with advanced DA who achieved complete remission (CR) after undergoing chemoradiotherapy combined with targeted therapy. The patient was pathologically diagnosed with DA after radical surgery in October 2020, and he failed to undergo adjuvant chemotherapy on time due to the COVID-19 outbreak. The patient found multiple lymph node liver and abdominal metastases 6 months after the operation. Considering the progression of the disease, XELOX regimen (oxaliplatin + capecitabine) chemotherapy was given for 1 cycle. After 1 cycle of treatment, the tumor markers remained elevated; the carcinoembryonic antigen (CEA) was 5.03 ng/ml (0–5 ng/ml), and the carbohydrate antigen 19-9 (CA19-9) was 747.30 U/ml (0–37 U/ml). The patient also developed intolerable capecitabine-related treatment-related adverse events (TRAEs), namely, hand–foot syndrome. For the above reasons, capecitabine was replaced as S-1 at cycle 2, and the chemotherapy regimen became SOX (oxaliplatin + S-1); bevacizumab injection was also added to the SOX regimen, and it was further treated regularly for 7 cycles with the regimen of SOX plus bevacizumab. Liver metastases showed a continuous narrowing trend throughout the treatment period; tumor markers also showed a downward trend. Finally, the patient achieved complete remission (CR) at cycle 7. After completion of chemotherapy, radiotherapy was administered to the resistant metastatic lymph nodes present in the patient’s abdominal cavity for a total of 10 times. However, the patient developed severe bone marrow suppression and obstructive jaundice during the course of radiotherapy and finally failed to complete the radiotherapy plan. Currently, the patient continued maintenance therapy with bevacizumab and S-1 and showed no recurrence or metastasis after review. In this case of advanced DA, we referred to both CRC and gastric cancer in the treatment regimen of the patient. At the same time, targeted drugs and radiotherapy were also added to the basis of chemotherapy, which has no clear consensus recommendation or case for reference in the treatment of advanced DA. Thankfully, the patient’s disease was controlled and remained stable after treatment with this regimen. Therefore, for patients with advanced DA who lack standardized treatment regimens and guidelines, the combination of chemotherapy with targeted therapy and radiotherapy may be one of the effective treatment modalities.
Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells
Authors: Yi Juan , Gong Xia , Yin Xiao-Yang , Wang Li , Hou Jin-Xia , Chen Jing , Xie Bei , Chen Gang , Wang Li-Na , Wang Xiao-Yuan , Wang Da-Chun , Wei Hu-Lai
Published: October 2022

Although arsenic trioxide (ATO) shows a strong anti-tumor effect in the treatment of acute promyelocytic leukemia, it does not benefit patients with hepatocellular carcinoma (HCC). Thus, combination therapy is proposed to enhance the efficacy of ATO. Parthenolide (PTL), a natural compound, selectively eradicates cancer cells and cancer stem cells with no toxicity to normal cells. In this study, we chose PTL and ATO in combination and found that nontoxic dosage of PTL and ATO co-treatment can synergistically inhibit the in vitro and in vivo proliferation activity of HCC cells through suppressing stemness and self-renewal ability and inducing mitochondria-dependent apoptosis. More importantly, USP7-HUWE1-p53 pathway is involved in PTL enhancing ATO-induced apoptosis of HCC cell lines. Meanwhile, accompanied by induction of apoptosis, PTL and ATO evoke autophagic activity via inhibiting PI3K/Akt/mTOR pathway, and consciously controlling autophagy can improve the anti-HCC efficacy of a combination of PTL and ATO. In short, our conclusion represents a novel promising approach to the treatment of HCC.
Efficacy of ketamine for comorbid depression and acute or chronic pain: A systematic review
Authors: Balachandran Aksharra , Tassone Vanessa K. , Adamsahib Fathima , Di Passa Anne-Marie , Kuburi Sarah , Demchenko Ilya , Ladha Karim S. , Bhat Venkat
Published: October 2022

Pain and depression frequently co-occur. Due to its antidepressant and analgesic properties, ketamine has been used for the management of treatment-resistant depression and pain. This systematic review examined the literature on the efficacy of sub-anesthetic doses of ketamine in individuals experiencing comorbid depression and chronic pain (CDCP), as well as comorbid depression and acute pain (CDAP). A secondary objective was to provide an assessment of dosage, route, and adverse effects of ketamine treatment for CDCP and CDAP. A literature search was conducted on MEDLINE, PsycINFO, and Embase databases, coupled with a manual screening of the bibliography sections of included articles. In addition, registered ongoing and planned trials were searched on Clinicaltrials.gov. The end date of the search was April 9th, 2022. Included studies assessed changes in depression and pain in patients receiving at least one sub-anesthetic dose of ketamine. Assessment of quality was conducted using the GRADE checklist. Of the 7 CDCP clinical trials, 3 reported a reduction in depression and pain, 3 reported a reduction in depression or pain only, and 1 reported no improvement in either comorbidity. Among the 7 CDAP clinical trials, 4 studies found improvements in depression and pain while the remaining 3 reported improvements in only one parameter. Ten of the 12 case studies and 2 of the 3 observational studies assessing CDCP and CDAP found improvements in pain and depression scores post-treatment with effects of variable duration. The planned methodologies of the registered clinical trials are in line with those of the published research. Preliminary evidence supports the efficacy of ketamine in treating CDCP and CDAP. However, the current review identified a small number of heterogeneous studies with mixed results, preventing comprehensive conclusions. More longitudinal placebo-controlled studies are needed to identify the effects of ketamine for patients with CDCP and CDAP.
Case Report: Recurrent pericardial tamponade in a child with COVID-19
Authors: Győri Ádám , Decsi Tamás , Stankovics József , Nyul Zoltán , Környei Mária , Masszi György , Leibinger Evelin , Mosdósi Bernadett
Published: October 2022

Background

Pericarditis is rare in Coronavirus disease 2019 (Covid-19) infection and only a few cases were reported in children.

Case presentation

We present the case of a 15-year-old boy with symptoms of high fever and worsening chest pain during COVID-19 infection. Chest computer tomography (CT) and echocardiography confirmed pericardial tamponade requiring urgent drainage. Despite antiviral drug treatment, after 18 days severe attack developed requiring repeated pericardiocentesis. High dose ibuprofen, colchicin and the interleukin-1 antagonist, anakinra were given. Clinical symptoms and laboratory parameters improved after seven days of treatment. Autoinflammatory diseases were also suspected in the background the severe pericarditis, but genetic analysis ruled out any mutations.

Conclusion

Pericarditis associated with COVID-19 infection may present in the acute phase or later as MIS-C. Though pericardial tamponade related to ongoing Covid-19 infection is rare in children, even biological treatment with interleukin-1 antagonist may be needed to control the inflammation.
Knowledge and practices related to antibiotic use among women in Malang, Indonesia
Authors: Yunita Sendi Lia , Yang Hui-Wen , Chen Yi-Chun , Kao Li-Ting , Lu Yi-Zi , Wen Yuan-Liang , To Sheng-Yin , Huang Ya-Li
Published: October 2022

Background:Antimicrobial resistance is a public health problem that threatens the efficacy of antibiotics. Incorrect knowledge of antibiotics may lead to their inappropriate use, hinder their effectiveness, and cause antibiotic resistance. Population-based educational campaigns have been found to have either mixed or no effect on improving knowledge and appropriate antibiotic practices, suggesting the need for more targeted approaches in tailoring education for specific subpopulations. Women are the primary caregivers of their families and are more willing to contact healthcare providers. They had greater knowledge of antibiotics and better adherence to the completion of the antibiotic regimen. Therefore, they are suitable for prioritization in a campaign program.

Objective:This study examined the knowledge and practices of female visitors to health centers in Malang, Indonesia with respect to antibiotic use.

Methods:This cross-sectional study was conducted in Malang, Indonesia, in July and August 2018. Data were collected from 677 women. Multivariate logistic regression was performed to identify the potential factors associated with antibiotic knowledge, self-medication, and completion of antibiotic regimens.

Results:Overall, 82.7% of respondents were aware that antibiotics are used against bacteria, while 38.4% reported self-medication with antibiotics and 51.7% reported completing antibiotic regimens. Women with higher education, previous antibiotic use experience, and very easy accessibility to primary doctors were more likely to have high antibiotic knowledge than those with primary education, no antibiotic use in the previous year, and easy/other level of accessibility to primary doctors. Subjects residing in urban areas and with less accessibility to primary doctors were more likely to self-medicate with antibiotics. Additionally, the completion of antibiotic regimens was positively associated with access to a primary care doctor and high antibiotic knowledge.

Conclusion:IF Policymakers tend to reduce inappropriate antibiotic use among women. Priority advocates are recommended for urban residents who have experiences of antibiotic use in the previous year. It is therefore important to increase their awareness, particularly regarding diseases against which antibiotics are effective, and activities such as unnecessary use of antibiotics in healthy animals, which may affect their overall effectiveness among humans. More communication channels should be included in the overall scheme to improve the public awareness and accessibility of health professionals.
Effect of sulfasalazine on endothelium-dependent vascular response by the activation of Nrf2 signalling pathway
Authors: Sonmez Muhammed Ikbal , Shahzadi Andleeb , Kose Cagla , Sonmez Haktan , Ozyazgan Sibel , Akkan Ahmet Gokhan
Published: October 2022

Background: Diabetes mellitus leads to endothelial dysfunction and accumulation of oxygen radicals. Sulfasalazine-induced Nrf2 activation reduces oxidative stress in vessels. Thus, in the present study, we investigated the effects of sulfasalazine on endothelial dysfunction induced by high glucose. We also ascribed the underlying mechanism involved in glucose-induced endothelial dysfunction.

Methods: For this experiment we used 80 Wistar Albino rats thoracic aorta to calculate the dose response curve of noradrenaline and acetylcholine. Vessels were incubated in normal and high glucose for 2 h. To investigate glucose and sulfasalazine effects the vessels of the high glucose group were pre-treated with sulfasalazine (300 mM), JNK inhibitor (SP600125), and ERK inhibitor (U0126) for 30 min. The dose response curve was calculated through organ bath. The eNOS, TAS, TOS, and HO-1 levels were estimated by commercially available ELISA kits.

Results: In the high glucose group, the Emax for contraction was significantly higher (p < 0.001), and Emax for relaxation was lower than that of control. These functional changes were parallel with the low levels of eNOS (p < 0.05). High glucose vessel treated with sulfasalazine showed low Emax value for contraction (p < 0.001) however, the Emax for relaxation was significantly high (p < 0.001) when compared to high glucose group. In the JNK group, Emax for contraction and relaxation was inhibited (p < 0.001) compared to sulfasalazine treated vessels. HO—1 enzyme levels were significantly low (p < 0.01) with sulfasalazine but higher with ERK inhibitor (p < 0.05).

Conclusion: High glucose induced endothelial dysfunction and sulfasalazine reduced damage in high glucose vessels by activating eNOS, antioxidant effect through HO-1 enzymes and particularly inducing Nrf2 via the ERK and JNK pathways.
Role of degree and weighted coreness based on endpoints in link prediction
Authors: Hao Jiaqi , Li Zheng , Wu Zhanhe , Ma Jinming
Published: October 2022

Many researchers propose link prediction models based on node similarity. Among all models, researchers found that the endpoint influence plays an important role in evaluating the similarity between endpoints. For endpoint influence, we consider that an endpoint possessing a large and extensive maximum connected subgraph can strongly attract other nodes. After thorough research, we found that the coreness can describe the aggregation degree of neighbors and the endpoint degree may be used to describe the largest connected subgraph of an endpoint. In order to create a model, we repeat our experiments on eight real benchmark datasets after combining endpoint degree and weighted coreness. The experimental results illustrate the positive role of synthetical endpoint degree and weighted coreness for measuring endpoint influence in link prediction.
QTL mapping for early root and shoot vigor of upland rice (Oryza sativa L.) under P deficient field conditions in Japan and Madagascar
Authors: Ranaivo Harisoa Nicole , Lam Dinh Thi , Ueda Yoshiaki , Pariasca Tanaka Juan , Takanashi Hideki , Ramanankaja Landiarimisa , Razafimbelo Tantely , Wissuwa Matthias
Published: October 2022

Upland rice production is limited by the low phosphorus (P) availability of many highly weathered tropical soils and P deficiency is likely to become increasingly limiting in future drier climates because P mobility decreases sharply with soil moisture. Good seedling root development will be crucial to cope with the combined effects of low P and water availability. Upland rice genebank accession DJ123 was used as a donor for P efficiency and root vigor traits in a cross with inefficient local variety Nerica4 and a set of backcross lines were used to characterize the seedling stage response of upland rice to low P availability and to identify associated QTL in field trials in Japan and Madagascar. Ten QTL were detected for crown root number, root, shoot and total dry weight per plant in a highly P deficient field in Japan using the BC1F3 generation. Of these, qPef9 on chromosome 9 affected multiple traits, increasing root number, root weight and total biomass, whereas a neighboring QTL on chromosome 9 (qPef9-2) increased shoot biomass. Field trials with derived BC1F5 lines in a low-P field in Madagascar confirmed a highly influential region on chromosome 9. However, qPef9-2 appeared more influential than qPef9, as the shoot and root biomass contrast between lines carrying DJ123 or Nerica4 alleles at qPef9-2 was +23.8% and +13.5% compared to +19.2% and +14.4% at qPef9. This advantage increased further during the growing season, leading to 46% higher shoot biomass at the late vegetative stage. Results suggest an introgression between 8.0 and 12.9 Mb on chromosome 9 from P efficient donor DJ123 can improve plant performance under P-limited conditions. The QTL identified here have practical relevance because they were confirmed in the target genetic background of the local variety Nerica4 and can therefore be applied directly to improve its performance.
Local endocytosis of sucrose transporter 2 in duckweed reveals the role of sucrose transporter 2 in guard cells
Authors: Liu Penghui , Fang Yang , Tan Xiao , Hu Zhubin , Jin Yanling , Yi Zhuolin , He Kaize , Wei Cuicui , Chen Rui , Zhao Hai
Published: October 2022

The local endocytosis of membrane proteins is critical for many physiological processes in plants, including the regulation of growth, development, nutrient absorption, and osmotic stress response. Much of our knowledge on the local endocytosis of plasma membrane (PM) protein only focuses on the polar growth of pollen tubes in plants and neuronal axon in animals. However, the role of local endocytosis of PM proteins in guard cells has not yet been researched. Here, we first cloned duckweed SUT2 (sucrose transporter 2) protein and then conducted subcellular and histological localization of the protein. Our results indicated that LpSUT2 (Landoltia punctata 0202 SUT2) is a PM protein highly expressed on guard cells. In vitro experiments on WT (wild type) lines treated with high sucrose concentration showed that the content of ROS (reactive oxygen species) in guard cells increased and stomatal conductance decreased. We observed the same results in the lines after overexpression of the LpSUT2 gene with newfound local endocytosis of LpSUT2. The local endocytosis mainly showed that LpSUT2 was uniformly distributed on the PM of guard cells in the early stage of development, and was only distributed in the endomembrane of guard cells in the mature stage. Therefore, we found the phenomenon of guard cell LpSUT2 local endocytosis through the changes of duckweed stomata and concluded that LpSUT2 local endocytosis might be dependent on ROS accumulation in the development of duckweed guard cells. This paper might provide future references for the genetic improvement and water-use efficiency in other crops.
Supplier concentration and corporate innovation input
Authors: Zou Meifeng , Zhang Xindong
Published: October 2022

This paper studies the relationship between supplier concentration and corporate innovation input. The results show that a firm with a higher supplier concentration tends to have lower R&D investments and invention patents. Considering endogenous problems, this negative relationship is still robust by using the instrumental variable regression and propensity score matching method. Mechanism analysis shows that a firm with higher supplier concentration is impaired risk-taking capacity and occupied resources by the big suppliers. Our evidence shows that a deeper exposure to a small set of large supplier bears negative consequences for the firm. This paper sheds new light on the dark side of a high level of supplier concentration on corporate innovation.
Modern applications of cross-classified random effects models in social and behavioral research: Illustration with R package PLmixed
Authors: Huang Sijia , Jeon Minjeong
Published: October 2022

Cross-classified random effects models (CCREMs) have been developed for appropriately analyzing data with a cross-classified structure. Despite its flexibility and the prevalence of cross-classified data in social and behavioral research, CCREMs have been under-utilized in applied research. In this article, we present CCREMs as a general and flexible modeling framework, and present a wide range of existing models designed for different purposes as special instances of CCREMs. We also introduce several less well-known applications of CCREMs. The flexibility of CCREMs allows these models to be easily extended to address substantive questions. We use the free R package PLmixed to illustrate the estimation of these models, and show how the general language of the CCREM framework can be translated into specific modeling contexts.
Can We Combine Senses to Create New “Super Senses” and Abilities?
Authors: Maimon Amber , Amedi Amir
Published: October 2022

Bats see with their ears, snakes see heat, horses can see almost 360° around them, and crickets have super hearing abilities through their legs. The development of these abilities took 10’s of 1,000’s of years of evolution. While these astonishing sensory abilities may sound like superpowers that only people in comic books have, new studies suggest that, by using technology and perceptual learning, humans too could develop some of these awe-inspiring abilities—sometimes with only a small amount of training!
Timber growth, cacao yields, and financial revenues in a long-term experiment of cacao agroforestry systems in northern Honduras
Authors: Ramírez-Argueta Oscar , Orozco-Aguilar Luis , Dubón Aroldo Dubón , Díaz Francisco J. , Sánchez Jesús , Casanoves Fernando
Published: October 2022

Cacao in Honduras is cultivated under traditional shade tree species (Inga sp., Erythrina sp., Gliricidia sp.), fruit and timber species deliberately planted or selected and managed from natural regeneration. Typically, the shade canopy of these cacao plantations is poorly managed resulting in high tree density and heavy shading, thus affecting cacao yield performance overtime. We assessed 12 cacao plots made up of 15–35 useful timber shade trees with varying spacing 6 × 9, 9 × 9, 8 × 10, and 10 × 12 m. Initially, each plot consisted of three shade components plus cacao. Plantain (Musa x paradisiaca) and madreado (Gliricidia sepium) were used as temporary shade and timber species, were selected as permanent shade. Dasometric data were retrieved to assess growth rates of timber species and cacao yield per plant were recorded to explore the effects of shade cover yield performance and the incidence of main diseases. Specifically, we: a) calculated growth rates and build curves for diameter (DBH), total height (Ht), and commercial volume (Vc) and compared the growing performance with ANOVA and DGC tests; b) run a correlation analysis between shade cover, timber basal area, cocoa yields, and the incidence of monilia and black pod. Statistical differences were found in terms of growth rates among timber species evaluated. Mean annual growth rates were 2.25 cm in DBH, 1 m in Ht, and the standing commercial timber gained was 4.2 m3ha−1year−1. Cocoa yields ranged between 950 and 1,365 kg ha1year1 and were negatively affected by both increased tree cover and timber basal area. Cacao yields were reduced up to 25% when tree cover and tree basal area were over 40% and 10 m2ha−1, respectively. Regardless of timber tree species, no significant effect of tree cover was found on the incidence of cacao diseases. After 22 years, total revenues were determined by the proportion of incomes provided by each component of the agroforestry systems assessed. Five out of 12 timber-based cacao plantations accumulated more than U$95,000 of combined revenues, equivalent to incomes of US$3775 ha−1 year−1. Timber-based cacao plantations are a promising alternative for farm diversification in northern Honduras.
Laser projector method for measuring postoperative acetabular anteversion after total hip replacement
Authors: Chen Wei-Cheng , Wu Tai-Yin , Chi Kuan-Yu , Weng Pei-Wei , Huang Yu-Min , Lin Yi-Chia , Liaw Chen-Kun
Published: October 2022

Introduction

For patients undergoing THR, measuring the postoperative acetabular anteversion precisely plays a pivotal role in the prognosis. However, using elliptical methods mandates computerized equipment that is frequently in shortage in remote areas and developing countries. We invented a laser projector utilizing the ellipse method to measure the acetabular anteversion directly. The aim is to examine the consistency and validity of the laser projector as compared to our original software, Elliversion.

Materials and Methods

We retrospectively collected 50 postoperative pelvis radiographs including acetabulum from our institution. One investigator first measured the anteversion of included radiographs through Elliversion software as the control group. Subsequently, two operators independently used the laser projector for measurements in two separate periods with 1-day intervals as the experimental group. Our analysis was comprised of intra- and inter-observer comparisons and reliability, which investigated both the consistency and validity, by using two-sample student's t-test and intraclass correlation coefficient.

Results

There was no significant difference in measuring the anteversion through laser projectors between two operators (p = 0.54), with excellent inter-observer reliability (ICC, 0.967). The estimated effect in the anteversion measurement between the Elliversion and laser projector was also comparable, with the ICC level of 0.984, indicating excellent reliability.

Conclusion

Our study reported the consistency and validity of this laser projector as there is no significant difference between Elliversion and Laser projector, notably with excellent intra- and inter-observer reliability. We look forward to helping elevate clinical acumen when doctors provide care to patients after THR, especially in remote areas.
Development of refrigeration and heat pump systems
Authors: Pearson Andy
Published: October 2022

Despite continual development over more than two centuries there is still great scope for significant development in the realms of mechanical cooling and heating. This paper reviews the nature of the historical development and identifies key motivations for technical development. It seeks to highlight where there is greatest need for future development in this ubiquitous technology. The story of the development of mechanical refrigeration is dominated by the choices made with regard to the working fluid used in the system. These choices dictate the operating parameters of temperature and pressure that the system must withstand as well as introducing constraints related to material compatibility, so the agenda for the mechanical development of systems is set by the selection of the refrigerant. All of these systems are classed as heat pumps because they extract heat from one location and deliver it to another. The commercial demand for mechanical cooling in the 19th century meant that all of these early heat pump systems were used for cooling. The concept of using the same cycle to deliver useful heat was not commercialised until the mid-twentieth century and in some ways this application of the heat pump is still in the early stages of development, particularly with regard to market penetration.
Reproduction in South American wild canids—A review
Authors: Carvalho Jaqueline Candido de , Souza Fabiana Ferreira , Kastelic John Patrick , Ferreira João Carlos Pinheiro
Published: October 2022

Canids occupy the top of the food chain and are fundamental in sustaining a wild animal/environmental balance. South America, the most biodiverse continent, has 11 species of canids inhabiting diverse biomes, with or without overlapping territories. Although several species are threatened, little is known about their reproductive biology. Remarkably, basic knowledge regarding ejaculate characteristics, sexual behavior, female reproductive cycles, pregnancy and management, and parturition are scarce or absent. These gaps complicate or preclude development of conservation programs. This review compiles the current knowledge of the reproductive biology of South American canids and discusses implications of this scenario.
An Enhanced Navigation Algorithm with an Adaptive Controller for Wheeled Mobile Robot Based on Bidirectional RRT
Authors: Jhong Bing-Gang , Chen Mei-Yung
Published: October 2022

A navigation algorithm providing motion planning for two-wheeled mobile robots is proposed in this paper. The motion planning integrates path planning, velocity planning and controller design. Bidirectional rapidly-exploring random trees algorithms (RRT) with path pruning and smoothing mechanism are firstly used to obtain a collision-free path to the robot destination with directional continuity. Secondly, velocity planning based on trapezoidal velocity profile is used in both linear and angular velocities, but the position error of the endpoint of the curve appears due to the coupling problem of the nonlinear system. To reduce the error, an approximation method is used to gradually modify several parts of time length of the trapezoidal velocity profile, so the continuity of the path can still be maintained. Thirdly, the controller keeping the robot on the planned path and velocity is designed based on the dynamic model of the robot. The parameters of this controller are estimated by the adaptive low, and the gain of controller is dynamic adjusted by fuzzy logic control to avoid the case that the control value is saturated. The controller stability and the convergence of tracking error is guaranteed by Lyapunov theory. Simulation results are presented to illustrate the effectiveness and efficiency.
Numerical and Experimental Study on Jet Trajectory and Fuel Concentration Distribution Characteristics of Kerosene Jet in Air Crossflow
Authors: Wang Kefu , Pei Fanqi , Li Feng
Published: October 2022

The fuel concentration distribution in an afterburner is a critical factor that affects its ignition, flameout, stability, and combustion efficiency. Additionally, the trajectory of the fuel jet directly affects the distribution of the downstream fuel. Hence, this paper studied the factors that affect a jet’s trajectory and fuel concentration distribution through numerical calculations. The change law of the fuel jet trajectory under various parameters was studied, and the jet penetration depth change rate was analyzed. Moreover, the empirical formula of the spanwise distribution range of the liquid fuel in front of the stabilizer was fitted. Furthermore, this study investigated fuel concentration distribution experimentally in the afterburner under normal temperature and pressure. The paper obtained the variation law of fuel concentration in the spanwise and radial directions, and the proportion of the gaseous fuel in the flow section under the influence of different parameters. Additionally, the spatial distribution of the droplet concentration was obtained, revealing that it increased initially, and then decreased in the flow direction, reaching a peak at the end of the recirculation zone. In the radial direction, two concentration peaks were found in the boundary of the recirculation zone and in the main flow region.
Wood Ash Additive for Performance Improvement of Gelatin-Based Slow-Release Urea Fertilizer
Authors: Manzoor Eefa , Majeed Zahid , Nawazish Shamyla , Akhtar Wasim , Baig Sofia , Baig Ayesha , Fatima Bukhari Syeda Manahil , Mahmood Qaisar , Mir Zainub , Shaheen Shahida
Published: October 2022

Urea is a crucial nutrient for plant growth, but because of its substantial losses due to nitrification, ammonification, and subsurface leaching, there is currently a push to reduce these losses. Urea is frequently uploaded and trapped in gelatin. In this research, the improvement of urea uploading and encapsulation efficiency is investigated using wood ash made from plant biomass (Pinus roxburghii). The 8 g w/v of gelatin was mixed with various concentrations of wood ash (from 4 to 16 g w/w), urea (from 4 to 24 g w/w), and glutaraldehyde (from 0.5 to 3 mL g−1) to prepare various formulations of slow-release fertilizer (SRF). According to this study, adding wood ash to gelatin increases its ability to upload and encapsulate urea. The urea on its surface and the metal in wood ash both considerably contribute to the compositional alterations in gelatin in SRFs, which were demonstrated by IR spectroscopy. Visualization from photographs revealed that the homogenous dispersion of wood ash improved structural compatibility. The water content of the SRF formulation showed that wood ash can reduce water absorption by changing how hydrophobic gelatin is. Wood ash improves the gelatin’s ability to reduce the rapid release of urea over time, according to testing of cumulative urea release from SRF. The optimal combinations for achieving the maximum 53.43% of urea uploading were 2.44 g of urea, 2.47 mL of glutaraldehyde, and 1.50 g of wood ash, according to the Box–Behnken model. The gelatin-based SRF that had been amended with wood ash was applied to the Mentha spicata plant, and the plant’s healthy development and higher chlorophyll content revealed its agronomic potential. This study has a significant contribution to the development of an affordable and more effective wood ash-modified gelatin-based SRF.
Effects of Straw Mulching Thickness on the Soil Health in a Temperate Organic Vineyard
Authors: Qin Tianyu , Wang Lan , Zhao Jianshe , Zhou Gaifang , Li Caihong , Guo Liyue , Jiang Gaoming
Published: October 2022

Soil mulching is one of the common measures applied in organic agricultural production which could replace plastic films and protect the environment. In order to fully evaluate the effects of different straw mulching thicknesses on soil health, maize straw was mulched with the thicknesses of 0 cm (CK), 2 cm, 4 cm and 6 cm on soil surface to assess the effects on soil temperature (ST) and moisture (SM), soil pH, soil organic carbon (SOC), total nitrogen (TN), C/N, soil aggregates and soil bulk density (SBD) in a temperate organic vineyard. We found that straw mulching had a significant regulating effect, with soil moisture being elevated with increasing mulching thickness by 5.8%, 9.0% and 11.1% compared with CK. The soil SOC content increased by 3.0%, 2.4% and 2.3%. Although soil pH and C/N significantly (p < 0.05) increased, they fluctuated with increasing mulch thickness. Straw mulching also increased the content of >2 mm soil particle size and elevated the mean weight diameter (MWD) and geometric mean diameter (GMD). The increasing mulching thickness prolonged the effect on the stability of soil aggregates. The 4 cm maize straw mulching thickness has the best effect for ecologically and environmentally managing warm-temperate organic vineyards so it may have a great application prospect on a global scale.
Antifungal Efficacy and Convenience of Krameria lappacea for the Development of Botanical Fungicides and New Alternatives of Antifungal Treatment
Authors: Zabka Martin
Published: October 2022

The support of trends in agriculture with limited or restricted use of pesticides is linked to the difficulty of protection against pathogenic and toxigenic fungi. Therefore, it is a great challenge to find alternatives to these dangerous fungi. These alternatives include using safe antifungal plant substances of medicinal or aromatic plants as components of botanical pesticides. Within 69 plant species, only 13 were selected as potentially of interest. However, the species Krameria lappacea, whose extraction yield (economic factor) achieved 17.6% and minimum inhibitory concentrations (MIC50) 0.11–1.24 mg mL−1, was found to be enormously advantageous. Extraordinary efficacy on a set of dangerous filamentous fungi, comparable to expensive essential oils or active phenolic compounds, was demonstrated. In the most effective extract fraction, two main substances from the group of neolignans, analogues of kramerixin, were detected by using GC-MS and LC-MS analysis, and their molecular structure was determined. The advantage of K. lappacea was discussed on the basis of the mode of action and chemical properties of the detected neolignans. K. lappacea could be a suitable source for environmentally friendly preparations, thanks to its high yield in simple extraction, excellent antifungal activity, broad antifungal spectrum, harmlessness, and assumed lower volatility of active compounds.
Effects of Cover Crops and Drip Fertigation Regime in a Young Almond Agroecosystem
Authors: Rubio-Asensio José Salvador , Abbatantuono Francesco , Ramírez-Cuesta Juan Miguel , Hortelano David , Ruíz José Luis , Parra Margarita , Martínez-Meroño Rosa María , Intrigliolo Diego S. , Buesa Ignacio
Published: October 2022

The sustainability of woody crop agroecosystems requires continued improvements to water, nutrient and soil management. In this work, the combination of resource availability or fertigation dose with soil management practices was tested in a 2 × 2 factorial design in a drip irrigated young almond orchard. The fertigation doses were: the farmer supply at 60% of crop evapotranspiration and full nutrient requirements and the half-farmer supply at 30% of crop evapotranspiration and half nutrient requirements. The soil management practices were: bare soil and cover crops in the inter-row (mixture of grasses and legumes). Tree growth, yield, water and nutrient status, and cover crop biomass and nutrient status were determined, as well as inter-row soil C and N concentration. Results showed that the effect of resource availability was independent of soil management and vice versa. The half farmer treatment reduced tree vegetative growth and yield compared to farmer treatment, due to a negative effect on the water status, without observing a decrease in the concentration of nutrients in leaves or fruit. Trees with cover crop also reduced growth and yield compared to bare soil management. This was due to a nutritional competition, mainly of Ca, Fe, Mn and Zn, rather than to a decline in tree water status. Cover crops sequester up to 1 t/ha/year of carbon but do not increase soil organic carbon, nor soil total nitrogen. Cover crops proved to be efficient in reducing soil nitrate concentration in the topsoil and therefore has potential to prevent its leaching. Deficit fertigation and the use of cover crops can be effective practices to preserve and save water and nutrient resources in Mediterranean agroecosystems, but should be established with caution so as not to compromise the profitability of the orchard.
Potential Native Bacilli Reduce Fumonisin Contamination in Maize
Authors: Mita Mamuna Mahjabin , Jannat Muhtarima , Bashar Samrin , Protic Ismam Ahmed , Saha Plabon , Masud Md. Mostafa , Islam Rummana , Islam Nazia Binta , Alam Md. Zahangir , Islam Md. Rashidul
Published: October 2022

In Bangladesh, Fusarium proliferatum is a prevalent pathogen of maize plants that poses a significant threat to human health and livestock by producing carcinogenic fumonisin. However, the use of the Bacillus species, which can colonize the infected plant parts, has been practiced globally to mitigate fumonisin contamination in maize. In this study, B. subtilis MMM1, a native isolate from the maize rhizosphere, was found to be the most effective antagonist against F. proliferatum, which reduced their mycelial growth and total fumonisin accumulation by 85.31% and 85.12%, respectively, over control through a fivefold reduction in fungal population (1.1 × 104 CFU/g maize grain) in vitro. Furthermore, out of the five bacilli used in this study, B. subtilis MMM1 was able to increase the root and, shoot length, and the vigor index of maize seedlings, by colonizing the fresh roots at 82 × 106 CFU/g root tissue. This suggests that B. subtilis MMM1 might be put forth both as a biocontrol agent and a plant growth promoter in Bangladesh to combat F. proliferatum. Nevertheless, evaluation of its efficacy in reducing fumonisin contamination in maize should be investigated under field conditions.
Low Concentration of Rotenone Impairs Membrane Function of Spodoptera litura Cells by Promoting Their Aggregation
Authors: Lin Sukun , Xu Kaijie , Zhang Qingpeng , Zhu Qiuming , Khan Muhammad Musa , Zhang Zhixiang , Cheng Dongmei
Published: October 2022

Rotenone is a widely used botanical insecticide, which can inhibit the mitochondrial respiratory chain of various insect cells, while the mechanism of its toxicity to insect cells needs further investigation. The purpose of this study was to understand the toxicity level of low (0.2 µg/mL) and high (20 µg/mL) concentrations of rotenone in Spodoptera litura cells (SL-1) using trypan blue and Coomassie brilliant blue staining assays. Our study found that rotenone possessed cytotoxicity against SL-1 cells with varying effects of action between high and low concentrations. After low-concentration rotenone treatment, the SL-1 cells showed obvious aggregation time-dependently, with the fastest aggregation rate observed under the first 8 h of treatment time, but no such phenomenon was observed at high concentration. Furthermore, this aggregation phenomenon caused SL-1 cells to squeeze each other and led to the destruction of the cell membrane structure and function. Taken together, the results suggested that treatment with a low concentration of rotenone exhibited a chronic toxic effect that was significantly different from treatment with a high concentration of rotenone, which provides new insight into the cytotoxic mechanism of rotenone.
Predicting Soil Textural Classes Using Random Forest Models: Learning from Imbalanced Dataset
Authors: Mallah Sina , Delsouz Khaki Bahareh , Davatgar Naser , Scholten Thomas , Amirian-Chakan Alireza , Emadi Mostafa , Kerry Ruth , Mosavi Amir Hosein , Taghizadeh-Mehrjardi Ruhollah
Published: October 2022

Soil provides a key interface between the atmosphere and the lithosphere and plays an important role in food production, ecosystem services, and biodiversity. Recently, demands for applying machine learning (ML) methods to improve the knowledge and understanding of soil behavior have increased. While real-world datasets are inherently imbalanced, ML models overestimate the majority classes and underestimate the minority ones. The aim of this study was to investigate the effects of imbalance in training data on the performance of a random forest model (RF). The original dataset (imbalanced) included 6100 soil texture data from the surface layer of agricultural fields in northern Iran. A synthetic resampling approach using the synthetic minority oversampling technique (SMOTE) was employed to make a balanced dataset from the original data. Bioclimatic and remotely sensed data, distance, and terrain attributes were used as environmental covariates to model and map soil textural classes. Results showed that based on mean minimal depth (MMD), when imbalanced data was used, distance and annual mean precipitation were important, but when balanced data were employed, terrain attributes and remotely sensed data played a key role in predicting soil texture. Balanced data also improved the accuracies from 44% to 59% and 0.30 to 0.52 with regard to the overall accuracy and kappa values, respectively. Similar increasing trends were observed for the recall and F-scores. It is concluded that, in modeling soil texture classes using RF models through a digital soil mapping approach, data should be balanced before modeling.