bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-19 Parental Vaccine Hesitancy: The Role of Trust in Science and Conspiracy Beliefs
Authors: Gentile Ambra , Alesi Marianna
Published: November 2024

Background. Parent vaccine hesitancy is a sensitive topic despite the benefits associated with children’s vaccination. Especially regarding the COVID-19 vaccination, parents displayed concerns about children’s vaccination, questioning their effectiveness and security. Although several studies were conducted on the general population, few studies investigated this relationship on parents’ intentions. Methods. An online survey was advertised from May to December 2022 on social networks, collecting data from 109 participants (90% F; mean age: 41.34 years, SD: ±6.40). The survey assessed sociodemographic characteristics, vaccine hesitancy through the Parents Attitude towards Childhood Vaccine—PAVC, trust in science through the Belief in Science Scale—BISS, and conspiracy beliefs through the Generic Conspiracist Beliefs Scale—GCBS. Results. In our sample, 29 parents (26.6%) scored more than 50 points to PAVC and, for this reason, were considered hesitant. Moreover, more than half of parents (60.6%) declared that they did not intend to vaccinate their children in the future. The path analysis model showed that parents with low education tended to have higher conspiracy beliefs (β = −0.40). Holding conspiracy beliefs (β = 0.28) and having low trust in science (β = −0.23) was associated with higher parent hesitancy and, in turn, no future intention to vaccinate their children for COVID-19 (OR = 0.83, p < 0.001). Conclusion. The results of the current paper suggest that targeted campaigns should be aimed at parents with lower levels of education, mainly on social media, debunking the most common fake news or myths, independently from the type of vaccine, and highlighting the importance of scientific research for improving people’s living conditions.
Correction: Li et al. Isolation and Identification of a Tibetan Pig Porcine Epidemic Diarrhoea Virus Strain and Its Biological Effects on IPEC-J2 Cells. Int. J. Mol. Sci. 2024, 25, 2200
Authors: Li Mei , Wang Meng , Xi Yao , Qiu Shantong , Zeng Qiaoying , Pan Yangyang
Published: November 2024

There was an error in the original publication [...]
SIGMAR1 Knockdown Enhances Oral Cancer Cell Chemosensitivity to Cisplatin via Decreased PD-L1 Expression
Authors: Chagas Pablo Shimaoka , Garcia Cristiana Bernadelli , Sousa Lucas Oliveira , da Silva Gabriel , Sousa Graziella Ribeiro de , Marcelino Rodolfo Cabral , de Matos Leandro Luongo , Kowalski Luiz Paulo , Salles Évila , Wang Lei , Baban Babak , Leopoldino Andréia Machado
Published: November 2024

Emerging evidence suggests that aberrant expression levels of Sigma1 (SIGMAR1, also known as sigma-1 receptor) have been implicated in the progression of various diseases, including cancer. However, its significance in oral cancer (OC) has not been thoroughly explored. To advance in this field, the present study aimed to investigate the impact of SIGMAR1 knockdown in oral cancer cells. To do so, we included in this study our cohort of human OC samples and OC cell lines, which were utilized for experimental verification through several in vitro assays. Our findings revealed that SIGMAR1 overexpression was associated with poor survival rates and positively correlated with PD-L1 overexpression in human oral cancer samples. Furthermore, SIGMAR1 inhibition led to a decrease in PD-L1 expression and sensitized oral cancer cells to cisplatin treatment by enhancing apoptosis. These results suggest that SIGMAR1 knockdown may present a promising strategy worthy of further exploration in the management of oral cancer.
Is Osteopontin a Reliable Biomarker for Endometriosis?
Authors: Zygula Aleksandra , Kiecka Kamil , Sankiewicz Anna , Kuzmicki Mariusz , Ciebiera Michal , Issat Tadeusz , Drygas Wojciech , Cendrowski Krzysztof , Gorodkiewicz Ewa , Laudanski Piotr
Published: November 2024

This study aimed to evaluate the concentration of osteopontin in peritoneal fluid and plasma as potential biomarkers for diagnosing endometriosis. Osteopontin levels were measured using surface plasmon resonance imaging (SPRI) biosensors in patients suspected of having endometriosis. Plasma samples were collected from 120 patients, and peritoneal fluid was collected from 86 patients. Based on the detection of endometriosis lesions during laparoscopy, participants were divided into a study group (patients with endometriosis) and a control group (patients without endometriosis). The results showed no significant differences in plasma osteopontin levels between women with endometriosis and the control group (19.86 ± 6.72 ng/mL vs. 18.39 ± 4.46 ng/mL, p = 0.15). Similarly, peritoneal fluid osteopontin concentrations did not differ significantly between patients with and without endometriosis (19.04 ± 5.37 ng/mL vs. 17.87 ± 5.13 ng/mL, p = 0.29). Furthermore, osteopontin levels in both plasma and peritoneal fluid were not significantly associated with the stage of endometriosis, the presence of endometrioma, or the menstrual cycle phase. The findings of this study do not support osteopontin concentration as a reliable biomarker for endometriosis. However, further research is necessary to explore osteopontin’s potential role in the disease.
The Impact of Nutrient Solution Electrical Conductivity on Leaf Transcriptome Contributing to the Fruit Quality of Cucumber Grown in Coir Cultivation
Authors: He Lizhong , Xu Wentao , Zhou Dongke , Yan Jun , Jin Haijun , Zhang Hongmei , Cui Jiawei , Miao Chen , Zhang Yongxue , Zhou Qiang , Yu Jizhu , Yu Xiang , Ding Xiaotao
Published: November 2024

Soilless cultivation is increasingly utilized in supplying essential nutrients for greenhouse crops. However, the impact of coir cultivation under varying electrical conductivity (EC) conditions on cucumber growth and fruit quality, particularly through the regulation of gene expression during the vegetative stage, remains uncertain. In this study, we performed metabolic measurements on cucumber in both vegetative and reproductive stages under three different EC conditions and found metabolic products such as some primary metabolites (cellulose, many uncharged amino acids) and some secondary metabolites (rutin, cucurbitacin B) accumulated the most under EC of 5 dS·m−1. Next, we conducted transcriptome profiling in cucumber leaves, revealing that the function of genes significantly regulated by EC was associated with photosynthesis, many anabolic processes, and membrane transport. Finally, a set of genes contributed to metabolites related to the fruit quality of cucumber were identified by the Orthogonal Partial Least Squares (O2PLS) analysis, including genes involved in the biosynthesis of amino acids, polysaccharides, and many secondary metabolites. Taken together, these findings suggest that coir cultivation in greenhouses with moderate EC can induce a transcriptome-wide change in gene expression, thereby contributing to enhancing the abundance of metabolites associated with cucumber fruit quality.
Supercomputer-Based Virtual Screening for Deoxyribonucleic Acid Methyltransferase 1 Inhibitors as Novel Anticancer Agents
Authors: Friedrich Lara Johanna , Guthart Axel , Zhou Min , Arimondo Paola B. , Efferth Thomas , Dawood Mona
Published: November 2024

Targeting epigenetics is a new strategy to treat cancer and develop novel epigenetic drugs with anti-tumor activity. DNA methyltransferases transfer the methyl group from S-adenosyl-L-methionine (SAM) to the cytosine residue in a CpG island, leading to the transcription silencing of the gene. Hypermethylation can frequently be observed in several tumor types. Hence, the inhibition of DNMT1 has become a novel approach to cure cancer. In this study, virtual screening and molecular docking were performed for more than 11,000 ligands from the ZINC15 database to discover new hypomethylation agents. Four candidate compounds were further tested for their effects on DNMT1 in silico and in vitro. Compounds 2 and 4 showed the best DNMT1 inhibitory activity, but only compound 4 was able to inhibit the growth of several cancer cell lines. The hypomethylation of the luciferase gene by compound 4 was verified by a CMV- luciferase assay using KG-1 cells. Additionally, compound 4 suppressed cell migration in a dose- and time-dependent manner in the wound healing assay. Moreover, cell cycle analyses demonstrated that compound 4 arrested CCRF-CEM cells and MDA-MB-468 cells in the G0/G1 phase. Also, compound 4 significantly induced early and late apoptosis in a dose-dependent manner. In conclusion, we introduce compound 4 as a novel DNMT1 inhibitor with anticancer activity.
Mechanism of Metal Complexes in Alzheimer’s Disease
Authors: Liu Yi , Ma Jiaying , Zhang Qianling , Wang Yi , Sun Qi
Published: November 2024

Alzheimer’s disease (AD) is a kind of neurodegenerative diseases characterized by beta-amyloid deposition and neurofibrillary tangles and is also the main cause of dementia. According to statistics, the incidence of AD is constantly increasing, bringing a great burden to individuals and society. Nonetheless, there is no cure for AD, and the available drugs are very limited apart from cholinesterase inhibitors and N-Methyl-D-aspartic acid (NMDA) antagonists, which merely alleviate symptoms without delaying the progression of the disease. Therefore, there is an urgent need to develop a medicine that can delay the progression of AD or cure it. In recent years, increasing evidence suggests that metal complexes have the enormous potential to treat AD through inhibiting the aggregation and cytotoxicity of Aβ, interfering with the congregation and hyperphosphorylation of tau, regulating dysfunctional synaptic and unbalanced neurotransmitters, etc. In this review, we summarize the current metal complexes and their mechanisms of action for treating AD, including ruthenium, platinum, zinc, vanadium, copper, magnesium, and other complexes.
Maternal Dietary Improvement or Leptin Supplementation During Suckling Mitigates the Long-Term Impact of Maternal Obesogenic Conditions on Inflammatory and Oxidative Stress Biomarkers in the Offspring of Diet-Induced Obese Rats
Authors: Pomar Catalina Amadora , Trepiana Jenifer , Besné-Eseverri Irene , Castillo Pedro , Palou Andreu , Palou Mariona , Portillo Maria P. , Picó Catalina
Published: November 2024

This study investigates the impact of maternal nutrition during lactation on inflammation and oxidative stress in the offspring of diet-induced obese rats, along with the potential benefits of leptin supplementation during suckling. Dams were fed either a standard diet (SD), a western diet (WD) before and during gestation and lactation (WD-dams), or a WD switched to an SD during lactation (Rev-dams). Offspring were supplemented with leptin or vehicle during suckling and then fed an SD or WD until four months. Offspring of the Rev-dams exhibited improved metabolic indicators, including lower body weight, reduced plasma levels of TNF-alpha, a higher adiponectin/leptin (A/L) ratio, enhanced liver antioxidant defenses, and decreased inflammation markers in white adipose tissue (WAT) compared to WD-dams, with sex differences. Leptin supplementation further modulated these markers, reducing oxidative stress in liver and inflammation in WAT and liver (e.g., hepatic Tnfa expression decreased by 45% (males) and 41% (females) in the WD group on an SD), and improving the A/L ratio, with effects varying by maternal conditions and sex. In conclusion, this study underscores the importance of maternal nutrition and leptin intake during suckling in shaping long-term metabolic and inflammatory health in offspring, offering strategies to mitigate the adverse effects of maternal obesity on future generations.
Transcription-Aided Selection (TAS) for Crop Disease Resistance: Strategy and Evidence
Authors: Huang Jiu , Qi Guangxun , Li Mei , Yu Yue , Zhang Erte , Liu Yuhui
Published: November 2024

A transcription-aided selection (TAS) strategy is proposed in this paper, which utilizes the positive regulatory roles of genes involved in the plant immunity pathways to screen crops with high disease resistance. Increased evidence has demonstrated that upon pathogen attack, the expression of diverse genes involved in salicylic acid (SA)-mediated SAR are differentially expressed and transcriptionally regulated. The paper discusses the molecular mechanisms of the SA signaling pathway, which plays a central role in plant immunity, and identifies differentially expressed genes (DEGs) that could be targeted for transcriptional detection. We have conducted a series of experiments to test the TAS strategy and found that the level of GmSAGT1 expression is highly correlated with soybean downy mildew (SDM) resistance with a correlation coefficient R2 = 0.7981. Using RT-PCR, we screened 2501 soybean germplasms and selected 26 collections with higher levels of both GmSAGT1 and GmPR1 (Pathogenesis-related proteins1) gene expression. Twenty-three out of the twenty-six lines were inoculated with Peronospora manshurica (Pm) in a greenhouse. Eight showed HR (highly resistant), four were R (resistant), five were MR (moderately resistant), three were S (susceptible), and three were HS (highly susceptible). The correlation coefficient R2 between the TAS result and Pm inoculation results was 0.7035, indicating a satisfactory consistency. The authors anticipate that TAS provides an effective strategy for screening crops with broad-spectrum and long-lasting resistance.
Targeted NGS Revealed Pathogenic Mutation in a 13-Year-Old Patient with Homozygous Familial Hypercholesterolemia: A Case Report
Authors: Chamoieva Ayaulym E. , Mirmanova Zhanel Z. , Zhalbinova Madina R. , Rakhimova Saule E. , Daniyarov Asset Z. , Kairov Ulykbek Y. , Baigalkanova Almira I. , Mukarov Murat A. , Bekbossynova Makhabbat S. , Akilzhanova Ainur R.
Published: November 2024

Familial hypercholesterolemia is an autosomal hereditary disease defined by an increased level of low-density lipoprotein cholesterol (LDL-C), which predisposes significant risks for premature cardiovascular disorders. We present a family trio study: proband, a 13-year-old Kazakh girl with homozygous familial hypercholesterolemia (HoFH) and her parents. HoFH is much more rare and severe than a heterozygous form of the disorder. HoFH patients generally present with LDL-C levels exceeding 13 mmol/L, resulting in early and life-threatening cardiovascular events within the first decades of life. In cases of neglected treatment, young patients have a risk of death from coronary diseases before the age of 30. The aim of this research was to identify genetic mutations in the affected patient and her parents. Genetic testing was necessary due to highly elevated LDL-C levels and the presence of multiple xanthomas. Targeted next-generation sequencing (NGS) was performed in this study using the Illumina TruSight cardio panel, which targets 174 genes related to cardiac disorders. The girl was diagnosed with HoFH based on the results of genetic testing. A biallelic mutation was observed in exon 3 of the low-density lipoprotein receptor (LDLR): c. 295 G>A (p.Glu99Lys). Sanger sequencing confirmed that the mutant gene was inherited from both parents. After confirming the genetic diagnosis of HoFH, the patient was treated with LDL apheresis and statins. This case report is the first study of HoFH in a pediatric patient from the Central Asian region. Globally, it emphasizes the need for increased clinical awareness among healthcare providers, as early detection and intervention are important for improving outcomes, particularly in pediatric patients with this rare genetic disorder.
Transcriptional Profiling Analysis Providing Insights into the Harsh Environments Tolerance Mechanisms of Krascheninnikovia arborescens
Authors: Zhang Hongyi , Wang Yingnan , Ma Binjie , Bu Xiangqi , Dang Zhenhua , Wang Yingchun
Published: November 2024

Krascheninnikovia arborescens, an endemic shrub in China, thrives in desertification-prone environments due to its robust biomass, hairy leaves, and extensive root system. It is vital for ecological restoration and serves as a valuable forage plant. This study explored the molecular mechanisms underlying K. arborescens’ adaptation to desert conditions, focusing on its physiological, biochemical, and transcriptomic responses to drought, salt, and alkali stresses. The results revealed that the three stresses have significant impacts on the photosynthetic, antioxidant, and ion balance systems of the plants, with the alkali stress inducing the most pronounced changes and differential gene expression. The clustering and functional enrichment analyses of differentially expressed genes (DEGs) highlighted the enrichment of the induced genes in pathways related to plant hormone signaling, phenylpropanoid biosynthesis, and transcription factors following stress treatments. In these pathways, the synthesis and signal transduction of abscisic acid (ABA) and ethylene, as well as the flavonoid and lignin synthesis pathways, and transcription factors such as MYB, AP2/ERF, bHLH, NAC, and WRKY responded actively to the stress and played pivotal roles. Through the WGCNA analysis, 10 key modules were identified, with the yellow module demonstrating a high correlation with the ABA and anthocyanin contents, while the turquoise module was enriched in the majority of genes related to hormone and phenylpropanoid pathways. The analysis of hub genes in these modules highlighted the significant roles of the bHLH and MYB transcription factors. These findings could offer new insights into the molecular mechanisms that enable the adaptation of K. arborescens to desert environments, enhancing our understanding of how other desert plants adapt to harsh conditions. These insights are crucial for exploring and utilizing high-quality forage plant germplasm resources and ecological development, with the identified candidate genes serving as valuable targets for further research on stress-resistant genes.
The Role of Hydrogen Sulfide in iNOS and APP Localization and Expression in Neurons and Glial Cells Under Traumatic Effects: An Experimental Study with Bioinformatics Analysis and Biomodeling
Authors: Rodkin Stanislav , Nwosu Chizaram , Kirichenko Evgeniya
Published: November 2024

Hydrogen sulfide (H2S) donors are emerging as promising candidates for neuroprotective agents. However, H2S-dependent neuroprotective mechanisms are not yet fully understood. We have demonstrated that an H2S donor (sodium sulfide, Na2S) reduces the expression of inducible NO synthase (iNOS) and amyloid-beta precursor protein (APP) in damaged neural tissue at 24 h and 7 days following traumatic brain injury (TBI). The application of aminooxyacetic acid (AOAA), an inhibitor of cystathionine β-synthase (CBS), produced the opposite effect. Seven days after TBI, iNOS expression was observed not only in the cytoplasm but also in some neuronal nuclei, while APP was exclusively localized in the cytoplasm and axons of damaged neurons. It was also shown that iNOS and APP were present in the cytoplasm of mechanoreceptor neurons (MRNs) in the crayfish, in axons, as well as in certain glial cells 8 h after axotomy. Na2S and AOAA had opposing effects on axotomized MRNs and ganglia in the ventral nerve cord (VNC). Multiple sequence alignments revealed a high degree of identity among iNOS and APP amino acid residues in various vertebrate and invertebrate species. In the final stage of this study, biomodeling identified unique binding sites for H2S, hydrosulfide anion (HS−), and thiosulfate (S2O32−) with iNOS and APP.
A Hybrid Semantic Representation Method Based on Fusion Conceptual Knowledge and Weighted Word Embeddings for English Texts
Authors: Qiu Zan , Huang Guimin , Qin Xingguo , Wang Yabing , Wang Jiahao , Zhou Ya
Published: November 2024

The accuracy of traditional topic models may be compromised due to the sparsity of co-occurring vocabulary in the corpus, whereas conventional word embedding models tend to excessively prioritize contextual semantic information and inadequately capture domain-specific features in the text. This paper proposes a hybrid semantic representation method that combines a topic model that integrates conceptual knowledge with a weighted word embedding model. Specifically, we construct a topic model incorporating the Probase concept knowledge base to perform topic clustering and obtain topic semantic representation. Additionally, we design a weighted word embedding model to enhance the contextual semantic information representation of the text. The feature-based information fusion model is employed to integrate the two textual representations and generate a hybrid semantic representation. The hybrid semantic representation model proposed in this study was evaluated based on various English composition test sets. The findings demonstrate that the model presented in this paper exhibits superior accuracy and practical value compared to existing text representation methods.
Design Principles to Reduce Vehicle Pocketing at Guardrail-to-Concrete Barrier Transitions
Authors: Kofler Desiree , Tomasch Ernst , Mader Christian , Jiraut Marco , Barnaš Alexander , Jantscher Olivier , Horvatits Johann , Gragger Karl
Published: November 2024

Road restraint systems (RRSs) on European roads are provided by several manufacturers and, hence, lead to differences in geometry, material, and mode of operation. Focusing on the combination of soft steel RRSs with relatively stiffer concrete RRSs, it is vital to consider the potentially critical deformation kinematics during vehicle impacts, such as vehicle pocketing. Since a statutory test procedure was not introduced until mid-2024, much of the transition construction (TC) on Austrian roads has remained untested. Knowledge of the design features to be implemented during the refurbishment of such TCs is of great interest. The main focus of this study was to derive constructive measures (CMs) that increase traffic safety and are applicable to various TCs already installed on roads. The first step involved deriving design principles whose implementations in TCs reduce the risk of critical vehicle or RRS behavior. Based on finite element simulations, the functionality of a TC featuring all derived design principles was examined. The effect of each individual CM was analyzed in a parameter study. The results from a TB61 impact simulation on the derived TC showed the effectiveness of CMs, achieving smooth vehicle redirection. Vehicle pocketing was limited to a minimum, and neither penetration of the TC nor rollover of the vehicle was observed. The analysis of the influence of each CM indicated positive, and in some cases, negative effects. The working width was mainly positively influenced by the compaction of the posts, an additional steel bar, and the chamfering of the first concrete element. A rather diverse picture is drawn regarding the influence on the tensile forces in the guardrails. Some CMs had both positive and negative effects on the distribution of forces in the upper and lower guardrails. Nevertheless, all CMs had positive effects on the tensile forces in the coupling. The chamfering of the first concrete element was the most effective measure to prevent vehicle pocketing. However, through the combination of all CMs, the positive effects predominated, ensuring the functionality of the TC as a whole. This study provides basic insights into the effectiveness of constructive measures, which can serve as a reference for the renovation of in-service TCs or in the development phase of new TCs to be certified.
On the Origin of Görtler Vortices in Flow over a Multi-Element Airfoil
Authors: Kokash Hussein , Mavriplis Catherine , Agbaglah Gbemeho Gilou
Published: November 2024

The flow characteristics of a 30P30N three-element high-lift airfoil at low Reynolds numbers O104 are examined through three-dimensional simulations using a high-order spectral element method. This study primarily investigates the flow structures of the slat cove and Görtler vortices formed on the upper surface of the main airfoil. Spanwise instability grows exponentially in the slat cove with a constant wavelength, corresponding to that of the subsequently formed Görtler vortices. Görtler number calculations show that curvature-induced centrifugal instability at the slat cusp leads to the subsequent formation of Görtler vortices. Proper orthogonal decomposition (POD) is used to analyze the development of flow structures in the slat cove in different time ranges. At early time, the flow in the slat cove is dominated by shear layers that evolve into spanwise perturbations. These perturbations further evolve into distinct bell-shaped structures close to the slat cusp and are advected to the upper surface of the main airfoil, leading to the formation of Görtler vortices.
Sonification of Deproteinized Bovine Bone Functionalized with Genistein Enhances Bone Repair in Peri-Implant Bone Defects in Ovariectomized Rats
Authors: Duarte Nathália Dantas , Mulinari-Santos Gabriel , Batista Fábio Roberto de Souza , Gomes Marcelly Braga , Monteiro Naara Gabriela , Silva Ana Cláudia Ervolino da , Gruber Reinhard , Lisboa-Filho Paulo Noronha , Gomes-Ferreira Pedro Henrique Silva , Okamoto Roberta
Published: November 2024

Estrogen deficiency is one of several contributing factors to catabolic changes in bone surrounding dental implants, impairing bone repair in defects requiring bone regeneration. Functionalizing bone substitutes is an alternative approach among various strategies to address this challenge. In this study, the aim was to evaluate the effect of functionalizing deproteinized bovine bone (Bio-Oss®, BO) with genistein via sonication on peri-implant bone defects in ovariectomized rats. The animals were randomly distributed according to the treatment into the following four groups (n = 10): BO sonicated with genistein (BOS + GEN), BO sonicated alone (BOS), untreated BO (BO), and blood clot only (CLOT). After twenty-eight days, implant removal torque was determined, and the peri-implant bone parameters were calculated based on computed microtomography. Additionally, the gene expression of bone turnover markers was evaluated. As a main result, the functionalization with genistein increased implant removal torque and the peri-implant bone volume in the BOS + GEN group compared to both BOS and BO groups (both p < 0.05). These findings suggest that the sonification of deproteinized bovine bone functionalized with genistein improves bone repair in peri-implant bone defects in ovariectomized rats.
Youth and Adolescent Athlete Musculoskeletal Health: Dietary and Nutritional Strategies to Optimise Injury Prevention and Support Recovery
Authors: Alcock Rebekah , Hislop Matthew , Vidgen Helen Anna , Desbrow Ben
Published: November 2024

Background: Despite the well-documented benefits of exercise and sports participation, young athletes are particularly vulnerable to musculoskeletal injuries. This is especially true during periods of rapid growth, sports specialisation, and high training loads. While injuries are an inevitable aspect of sports participation, the risk can be minimised by promoting the development of strong, resilient tissues through proper nutrition and injury prevention strategies. Moreover, targeted nutrition strategies can accelerate recovery and rehabilitation, allowing for a quicker return to sports participation. Methods: This narrative review synthesises scientific evidence with practical insights to offer comprehensive dietary recommendations aimed at strengthening tissues and supporting the healing process during recovery and rehabilitation. The selection of all sources cited and synthesised in this narrative review were agreed upon by contributing author consensus, experts in sports nutrition (R.A., H.V., B.D.) and exercise and sports medicine (M.H.). Results: Key topics include factors that contribute to injury susceptibility, general dietary recommendations for growth and development, sports nutrition guidelines, and nutrition considerations during injury and rehabilitation. This review also addresses external factors that may lead to suboptimal nutrition, such as food literacy and eating disorders. Conclusions: By highlighting these factors, this article aims to equip coaches, nutritionists, dietitians, athletic trainers, physical therapists, parents/guardians, sporting organisations, and schools with essential knowledge to implement effective nutritional strategies for injury prevention, recovery, and rehabilitation, ultimately enhancing long-term health and athletic performance.
The Differential Effects of Augmented Reality and Product Presentation Strategies on Brand Recall: An Embodied Cognition Perspective
Authors: Zhou Liying , Niu Limin , Zhao Taiyang
Published: November 2024

As augmented reality (AR) technology becomes more prevalent in marketing, its impact on consumer memory processes, particularly brand recall, remains underexplored. This study primarily employs an empirical research method, using two lab experiments to examine the interaction between product presentation formats (AR vs. non-AR) and presentation strategies (separate vs. collocation) in brand recall. Across two experiments, we showed that AR enhances brand recall only in collocation presentations, where multiple products are displayed together, but not in separate presentations of individual products. In single-product contexts, AR formats do not demonstrate a significant advantage over non-AR formats. These findings suggest that AR’s effectiveness is contingent on presentation strategy, highlighting the contextual boundaries of AR’s utility in influencing consumer memory. By integrating embodied cognition theory with associative network theory, this research advances our understanding of how immersive technologies shape brand recall, offering strategic insights for marketers seeking to leverage AR in diverse product presentation scenarios.
Behavioral Observations of Free-Living Scarlet Macaws (Ara macao) in Costa Rica, to Inform Ex Situ Management
Authors: Lemos de Figueiredo Ricardo , Chappell Jackie
Published: November 2024

The scarlet macaw (Ara macao) is a charismatic species that is native to Central and South America and commonly housed in captivity. Gaps in knowledge about these birds’ behavioral ecology in the wild hinders both in situ and ex situ management and conservation efforts for this species. We conducted seventeen days of observations of free-living scarlet macaws in two locations in Costa Rica, in February 2022, with the aims of (1) advancing our knowledge of this species’ natural behavioral ecology, and (2) generating data for comparison with captive macaws to help to inform their ex situ management (e.g., enclosure design and enrichment). Routes were walked within two locations—Bosque Escondido (BE), release area for captive-bred reintroduced individuals and no extant wild population, and Punta Leona (PL), an area of natural habitat within a resort inhabited by wild scarlet macaws—and focal interval sampling of multiple scarlet macaws in a group was used to record behavior and space use. The macaws at both locations were generally active, spent most of their time high in the tree canopy, relied on climbing to move within it, and used a wide variety of supports. The macaws at PL spent significantly more time feeding and locomoting, and less time perching, than those at BE, possibly due to differences in resource availability, rearing conditions, and age. Furthermore, the wild scarlet macaws at PL exhibited a variety of foraging strategies to acquire and manipulate food items within the tree canopy, including frequent use of their feet during manipulation. Despite limitations caused by a small sample size, a short period of observations, and differences between the two populations observed, this study provides insights into the behavioral ecology of scarlet macaws in the wild, which can be used for behavioral assessments of captive macaws while informing their ex situ management, with applications to animal welfare and captive breeding programs.
Side-Eye from the Side Kid: Child Sidekicks as Disciplinary Tools in Contemporary Video Games
Authors: Reay Emma Joy
Published: November 2024

In this article, I analyse the function of supporting child-characters in contemporary videogames. I integrate Stephen Zimmerly’s typology of sidekicks in Young Adult literature with critical writing on the ‘Daddening’ of videogames, a coinage that refers to the rise in the number of videogames that centre on the filial bond between a father figure and a child. Bringing these ideas into conversation with each other allows me to expand Zimmerly’s sidekick typology to include the ‘Ludic Gateway’, the ‘Morality Certificate’, and the ‘Disciplinary Tool’. I explore each category in greater depth using two case studies: The Last of Us series (2012; 2014; 2020) and the God of War series (2008; 2018; 2022). These commercially successful, critically acclaimed franchises rely on young deuteragonists to humanize and redeem the gruff, aggressive, violent male player character. Furthermore, the child sidekicks also serve to regulate the player’s in-game behaviour by way of a parasocial relationship. Using a close reading approach, I demonstrate that the supporting child-characters function as meta-critical devices to discipline gaming communities and the video game medium itself.
Analysing the Influence of Augmented Reality on Organization Performance via Supply and Logistics Value Chain Functions: A Hybrid ANN-PLS Model Assessment in the Gulf Cooperation Council Region
Authors: Aburayya Ahmad
Published: November 2024

Background: Despite the resurgence of interest in augmented reality (AR) due to Industry 4.0 and its ability to resolve several challenges faced by current business models, comprehensive research examining the capabilities of AR in supply chain management (SCM) and logistics remains limited. This article aims to investigate the potential effects of AR technology on organizational performance through the mediation role of SCM and logistics value chain functions to address the existing knowledge gap. Methods: This research employed a cross-sectional design and an explanatory survey as a deductive approach for hypothesis development. The primary data collection method involved the self-administration of a questionnaire to furniture suppliers located in the Gulf Cooperation Council (GCC), including six countries. Of the 656 questionnaires submitted to suppliers, 483 were considered usable, yielding a response rate of 73.6%. The research utilized partial least squares structural equation modelling (PLS-SEM) and artificial neural network (ANN) techniques to evaluate the gathered data. Results: The current paper’s statistical evidence demonstrates that AR implementation has a positive impact on the supply and logistics value chain activities and organizational performance of furniture suppliers in the GCC region. Moreover, it illustrates that the design and planning variable of supply chain value dominates as the primary predictor of organization performance. The results indicated that the ANN strategy provided a more comprehensive explanation of internally generated constructs compared to the PLS-SEM technique. Conclusions: This study demonstrates its usefulness by advising furniture industry decision-makers on what to avoid and what aspects to consider when creating plans and regulations. The report also suggests operations managers apply machine learning (ANN) for prediction and decision-making in supply and operations value chains. This essay looks at how the AR and resource-based supply value chain view may affect company performance across countries, firm sizes, and ages.
Cyclic Fatigue Failure of Perforated 3D-Printed Polylactide (PLA) Specimens by Inserted Pin Loading
Authors: Hertel J. S. , Kwon Y. W. , Sachau D.
Published: November 2024

The failure of 3D-printed Polylactide (PLA) specimens with circular holes was studied under tensile and cyclic loading, respectively, by an inserted pin. Experiments were conducted for the perforated PLA specimens with various print angles from 0° to 90°, as well as [0°/90°]s and [0°/±45°/90°]s. The hole locations varied along the specimens. The PLA specimens showed two different failure modes: one through the print lines and the other between the print lines. Different print angles resulted in different tensile failure stresses under pin loading. The cyclic tests of different print angles showed very similar S-N data as the applied stresses were normalized to their tensile failure stresses if the failure mode was through the print lines. On the other hand, cyclic failure between print lines showed distinctly separated S-N data, even with the normalized applied stresses. The tensile failure stresses, failure locations, and orientations were successfully predicted using the failure criterion that is based on both stress and stress gradient conditions. A proposed mathematical interpolation equation provided good estimations of the tensile failure stresses and S-N curves of specimens with different print angles once the failure stresses were known for the 0° to 90° specimens.
Stabilization and Solidification of Beryllium Waste: Influence of the Cement Composition on the Corrosion of Be Metal
Authors: Laflotte Richard , Cau Dit Coumes Céline , Haas Jérémy , Rodrigues David , Cannes Céline , Delpech Sylvie , Rivenet Murielle
Published: November 2024

Beryllium metal is used as neutron moderator and reflector or multiplier in certain types of fission or fusion reactors. Dismantling of these reactors will produce radioactive beryllium waste, classified as low- or intermediate-level waste, that will need to be stabilised and solidified before being sent to disposal. The cementation process is under consideration because it may offer a good compromise between simplicity of implementation, cost, and quality of the final cemented wasteform. Nevertheless, knowledge of the corrosion behaviour of Be metal in a cement-based matrix is still limited, partly due to the high toxicity of Be that complicates testing. This study thus investigates Be corrosion in cement suspensions using potentiometry, voltammetry, and electrochemical impedance spectroscopy. Among the five different investigated systems (Portland cement blended without or with 40 wt.% silica fume, calcium sulfoaluminate clinker blended without or with 15% anhydrite, and calcium aluminate cement), Portland cement blended with 40% silica fume and calcium sulfoaluminate cement comprising 15% anhydrite are the most effective in mitigating beryllium corrosion. They allow reduction in the corrosion current by factors of 4 and 50, respectively, as compared to Portland cement.
Near-Surface Reconfiguration of Biopolymer Blends by Mechanical Embossment: Creation of Friction-Reduced Foils
Authors: Liu Hang , Kiefel Markus , Reichel Nova , Hofmann Jochen , Walcher Tobias , Schulz Wadim , Weber Katharina , Albrecht Joachim
Published: November 2024

Biopolymer blends of polylactic acid (PLA) and polybutylene adipate-co-terephthalate (PBAT) are extruded into flexible monolayer films. These blends are excellent candidates for the realization of environmentally friendly packaging applications. A necessary pre-requisite for that are appropriate tribological properties under mechanical contact. Reasonable wear resistance allows good protection of packed goods, and low friction forces reduce difficulties in stacking. In this research, mechanical embossment under high loads at room temperature was used for the modification of polymer surfaces to exhibit a significant friction reduction under dry conditions. The results particularly show a systematic decrease in the coefficient of friction for biopolymer blends containing 30 wt% and 40 wt% PBAT. FTIR was used to analyze the change in surface composition after mechanical embossing. A sophisticated FTIR calibration method revealed that the blend with 30 wt% PBAT shows a modified distribution of PBAT and PLA at the surface due to mechanical embossment. This leads to a controlled and long-lasting modification of the surface properties without a substantial change in the chemical composition of the polymer in bulk. Without the use of additional coatings, biodegradable packaging foils with improved characteristics are accessible.
Feature Paper Collection of Mathematical and Computational Applications—2023
Authors: Rozza Gianluigi , Schütze Oliver , Fantuzzi Nicholas
Published: November 2024

This Special Issue comprises the second collection of papers submitted by both the Editorial Board Members (EBMs) of the journal Mathematical and Computational Applications (MCA) and the outstanding scholars working in the core research fields of MCA [...]
The Challenges of Local Intra-Articular Therapy
Authors: Kirdaite Gailute , Denkovskij Jaroslav , Mieliauskaite Diana , Pachaleva Jolita , Bernotiene Eiva
Published: November 2024

Fibroblast-like synoviocytes (FLSs) are among the main disease-driving players in most cases of monoarthritis (MonoA), oligoarthritis, and polyarthritis. In this review, we look at the characteristics and therapeutic challenges at the onset of arthritis and during follow-up management. In some cases, these forms of arthritis develop into autoimmune polyarthritis, such as rheumatoid arthritis (RA), whereas local eradication of the RA synovium could still be combined with systemic treatment using immunosuppressive agents. Currently, the outcomes of local synovectomies are well studied; however, there is still a lack of a comprehensive analysis of current local intra-articular treatments highlighting their advantages and disadvantages. Therefore, the aim of this study is to review local intra-articular therapy strategies. According to publications from the last decade on clinical studies focused on intra-articular treatment with anti-inflammatory molecules, a range of novel slow-acting forms of steroidal drugs for the local treatment of synovitis have been investigated. As pain is an essential symptom, caused by both inflammation and cartilage damage, various molecules acting on pain receptors are being investigated in clinical trials as potential targets for local intra-articular treatment. We also overview the new targets for local treatment, including surface markers and intracellular proteins, non-coding ribonucleic acids (RNAs), etc.
Celebrating Moises A. Carreon: Special Edition Tribute to an Innovator in Membranes and Materials Science Research
Authors: Venna Surendar R.
Published: November 2024

Professor Moises A [...]
Enhancing CO2/N2 and CO2/CH4 Separation Properties of PES/SAPO-34 Membranes Using Choline Chloride-Based Deep Eutectic Solvents as Additives
Authors: Cardoso Jonathan S. , Lin Zhi , Brito Paulo , Gando-Ferreira Licínio M.
Published: November 2024

CO2 separation is an important environmental method mainly used in reducing CO2 emissions to mitigate anthropogenic climate change. The use of mixed-matrix membranes (MMMs) arrives as a possible answer, combining the high selectivity of inorganic membranes with high permeability of organic membranes. However, the combination of these materials is challenging due to their opposing nature, leading to poor interactions between polymeric matrix and inorganic fillers. Many additives have been tested to reduce interfacial voids, some of which showed potential in dealing with compatibility problems, but most of them lack further studies and optimization. Deep eutectic solvents (DESs) have emerged as IL substitutes since they are cheaper and environmentally friendly. Choline chloride-based deep eutectic solvents were studied as additives in polyethersulfone (PES)/SAPO-34 membranes to improve CO2 permeability and CO2/N2 and CO2/CH4 selectivity. SAPO-34 crystals of 150 nm with a high surface area and microporosity were synthesized using dry-gel methodology. The PES/SAPO-34 membranes were optimized following previous work and used in a defined composition, using 5 or 10 w/w% of DES during membrane preparation. All MMMs were characterized by their ideal gas permeability using N2 and CO2 pure gasses. Selected membranes were also tested using CH4 pure gas. The results presented that 5 w/w%, in polymer mass, of ChCl–glycerol presented the best result over the synthesized membranes. An increase of 200% in CO2 permeability maintains the CO2/N2 selectivity for the non-modified PES/SAPO-34 membrane. A CO2/CH4 selectivity of 89.7 was obtained in PES/SAPO-34/ChCl-glycerol membranes containing 5 w/w% of this DES, which is an outstanding ideal separation performance for MMMs when compared to other results in the literature. FTIR analysis reiterates the presence of glycerol in the membranes prepared. Dynamic Mechanical Thermal Analysis (DMTA) shows that the addition of 5 w/w% of DES does not impact the membrane flexibility or polymer structure. However, in concentrations higher than 10 w/w%, the inclusion of DES could lead to high membrane rigidification without impacting the overall thermal resistance. SEM analysis of DES-enhanced membranes presented asymmetric final membranes and reaffirmed the results obtained in DMTA about rigidified structures and lower zeolite–polymer interaction with higher concentrations of DES.
Kinetic Analysis of Molten Oxide Reduction Using Bottom-Blown Hydrogen Injection
Authors: Lu Lijin , Wang Feng , Wang Haifeng , Qiu Jian , Ping Xiaodong
Published: November 2024

Hydrogen-based smelting reduction has received widespread attention as an important technology for realizing low-carbon development in hydrogen metallurgy. In this study, the thermodynamics of smelting reduction was firstly analyzed by using FactSage 8.1 thermodynamic software, on the basis of which smelting reduction experiments of iron oxides by using bottom-blown hydrogen were carried out. The experiments used oxidized pellets as experimental materials, and the effects of the reduction process were analyzed in terms of the reduction temperature, the reduction time, and the hydrogen flow rate. The experimental results show that under the experimental conditions of a temperature of 1550 °C and a hydrogen flow rate of 0.2 Nm3/h, the reduction rate of iron oxides in the process of reducing iron oxides by hydrogen is significantly faster in the first 10 min than after 10 min. The hydrogen utilization rate reached a maximum of 41.87%, then decreased continuously and finally maintained at about 20%. Using the method of model fitting, it was found that the hydrogen-based molten reduction conformed to the phase boundary reaction model (Gα=1−(1−α)1/2), the corresponding mechanism function is fα=2(1−α)1/2, where α stands for the reduction conversion, and the reaction rate constant k(T) is 2.37 × 10−4 s−1 under the experimental conditions.