bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in the length of the fetal femoral percentile associated with giving zinc to pregnant women
Authors: Sitepu Makmur , Muhammad Yusuf Rachmatsyah
Published: January 2025

Background: Pregnancy is a uniquely critical and sensitive period in a woman's life. The pregnancy conditions are determinants in the successful growth of the fetus and baby. Zinc is important in fetal bone growth (ossification) because zinc deficiency in pregnancy can interfere with fetal bone formation. Being short (stunted) at birth is associated with a high risk of shortness in childhood and adulthood. Several ultrasound parameters can assess the intrauterine growth and development of the fetus, one of which is the length of the femur: the measurement of the length of the femur can detect intrauterine stunting early. The objective of this study was to investigate the average length of fetal femurs in pregnant women given zinc tablets and assess differences in the percentile changes in fetal femoral length between pregnant women given zinc tablets and those not given zinc tablets.
Methods: This prospective design observational analytic study was conducted at Universitas Sumatera Utara Hospital and other hospitals from June to November 2019. Eligible subjects were pregnant women who met the inclusion criteria and were collected with consecutive sampling techniques.
Results: Fetal femur length was examined using ultrasonography on 31 subjects given zinc tablets and 31 who were not. The average fetal femur length prior to treatment was 61.97 mm (SD=8.13 mm) and 58.84 mm (SD=9.37 mm), respectively. There was no significant difference in the mean length of fetal femurs (p=0,110) prior to treatment. Fetal femur length increase in subjects given zinc tablets was 27.74 mm (SD=5.32 mm), whereas in subjects not given zinc tablets was 23.08 mm (SD=2.81 mm).
Conclusion: There were significant fetal femoral length percentile changes in pregnant women given zinc tablets.
Symptoms identification of ICD-11 based on clinical NLP mobile apps for diagnosing the disease (ICD-11)
Authors: Budiarti Rizqi Putri Nourma , Sritrusta Sukaridhoto  , Ilham Achmad Al-Hafidz  , Naufal Adi Satrio
Published: January 2025

Introduction: There are still many people in Indonesia who are not aware of the importance of information related to the early symptoms that must be experienced when they become patients. Not infrequently, this lack of information disclosure results in misdiagnosis and even leads to unexpected death. Anamnesis is a process where the doctor or medical record nurse gives several questions about the clinical pathway in the form of a narrative to facilitate early identification of the disease, and the results of this history-taking process are stored in the Electronic Medical Record (EMR). EMR narratives often cannot be processed by computers if language literacy is not standardized or ambiguous, so the need to overcome this problem requires the use of technology to minimize misdiagnosis and facilitate the identification process by developing digitization in the form of mobile applications that are integrated with Natural Language Processing technology and ICD-11 in the symptom identification process. This study aims to identify ICD-11 symptoms based on clinical NLP mobile application to diagnose the disease (ICD-11).
Methods: The applications of Natural language processing includes literature study, Voice Recognition, Tokenization, Stemming, The process of Stopwords Removal, Named Entity Recognition, Data Translation, Access ICD Data, and Mobile User Interfaces.
Results: Named Entity Recognition (NER) is used to identify symptoms of digestive system diseases, with an accuracy rate of 74.3%. In stemming and stopwords processing, the NLP accuracy rates are 95.9% and 97.2%, respectively.
Conclusions: This research focuses on the application mobile and development of the Named Entity Recognition (NER) model. The importance of the NLP process in the development of information, especially for word processing, aims as a device that simplifies speech recognition systems to be more helpful.
The use of telemedicine in COVID-19 pandemic era: a systematic review
Authors: Martha Nur Aditya Dwi , Pintoko Kalanjati Viskasari , Bathoro Bagus Pamungkas Dimas , Rahmayanti Syamhadi Maya , Angelina Soegiharto Wibowo Jesslyn , Muliawan Soetanto Kevin
Published: January 2025

Introduction: Telemedicine is a form of healthcare that uses technology to provide various health services. This method has been widely used during the COVID-19 pandemic when physical distancing is called. This systematic review aimed to review various uses of telemedicine on 11 databases using the PRISMA flowchart from January 1st, 2020, to December 31st, 2021.
Methods: This review has been registered in PROSPERO (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=269809). The search terms are: "COVID-19," "Coronavirus," "SARS-CoV-2," "2019-nCoV," "Telemedicine," "Telehealth," "Teleconsultation," "Telemonitoring," "Telemanagement," "Teleconferencing," "Video conferencing," "Video consultation," "Virtual care," "Virtual service," "Virtual treatment," "Remote treatment," "Remote service," "Remote consultation," "Digital care," "Digital treatment," "Mobile health," and "E-health." The quality assessment used indexed databases for the SCOPUS, Web of Science (ESCI), and PubMed (PMC and Medline).
Results: On initial scrutiny, 2.031.242 articles were obtained; after screening with inclusion and exclusion criteria, 17 articles were included. Only 4 articles reported the use of telemedicine for respiratory-related diseases patients; 3 of these were COVID-19-related cases. Other 13 articles reported the use of telemedicine for admission, anamnesis, diagnosis, treatment, follow-up, and monitoring purposes for non-respiratory-related diseases. Methods applied include voice calls, video conferences, and specific software on computers and smartphones. There were no significant differences between telemedicine and the face-to-face method, although the lack of health providers' presence has been complained about in the prior method.
Conclusion: From this review, telemedicine is a beneficial tool for delivering health services during the COVID-19 pandemic.
Ultrasound assessment of femoral cartilage thickness among healthy Indonesian adults
Authors: Pane Rita Vivera , Aisyah  , Ariani Hajar , Isparnadi Erwien , Al Hajiri Aufar Zimamuz Zaman , Setiawan Albert
Published: January 2025

Background: Ultrasound (US) is a reliable, non-invasive, and inexpensive modality for evaluating femoral cartilage (FC) thickness. Several studies evaluated the US accuracy in assessing FC thickness by comparing it to MRI and macroscopic measurements, reporting that the US exhibit highly accurate FC thickness measurement. This study evaluated the FC thickness among healthy Indonesian adults using ultrasound US assessment.
Methods: An analytical observational study with a cross-sectional design was conducted in Surabaya Hajj General Hospital, Indonesia, from April to August 2022. A total of 127 participants with no symptoms or pathologies on both knees were involved in the study. In this study, a certified examiner performed the ultrasound scanning in three sites: medial condyle (MC), intercondylar (IC), and lateral condyle (LC) of both knees.
Results: A total of 254 knees from 127 healthy Indonesian adults were examined. The participants’ mean age was 32.83 years. Most of them were female (69%). Participants’ average weight, height, and BMI were 62.25 kg, 161.17 cm, and 23.93, respectively. The mean FC thickness of the right MC, IC, and LC was 1.76 mm, 1.92 mm, and 1.71 mm, respectively. Meanwhile, the mean FC thickness of left MC, IC, and LC was 1.76 mm, 1.89 mm, and 1.69 mm, respectively. This study found that FC thickness was associated with gender (<0.05) but not age and BMI.
Conclusion: Mean FC thickness among healthy Indonesian adults of MC, IC, and LC were 1.76 mm, 1.89 –1.92 mm, and 1.69 – 1.71 mm, respectively. The IC mean was higher than the MC and LC means. Mean FC thickness on both sides was associated with gender but not age and BMI.
Controversial of SARS-CoV-2 transmission in pregnant mothers: a review
Authors: David Tjahyadi
Published: January 2025

Pregnant women are a population group at high risk of contracting SARS-CoV-2. Several cases have been reported, including diabetic ketoacidosis and hypertension, diabetes mellitus and hypertension, and heart disease associated with COVID-19. In addition, it is also reported that pregnant women are also exposed to SARS-CoV-2. Most pregnant women with COVID-19 show mild symptoms. The placenta is usually an effective barrier to prevent the spread of infection from mother to fetus (vertical transmission). Certain pathogens can overcome this barrier, with effects that are sometimes detrimental to the development of pregnancy. Vertical infection of SARS-CoV-2 from mother to fetus is possible, although there is no adequate evidence. It has been reported that in pregnant women with COVID-19, the vertical transmission of SARS-CoV-2 from mother to fetus is low. The transmission of SARS-CoV-2 from mother to fetus occurs in the third trimester of pregnancy. Although there is vertical transmission of SARS-CoV-2 from mother to fetus, there are no reports of adverse effects in neonates.
The results of another study explained that in the case of pregnant women who were confirmed positive for COVID-19, there was an gene expression of the ACE2 receptor, N and S proteins from SARS-CoV-2 in the placenta. This study's results contradict the opinion that ACE2 and TMPRSS2 in the placenta that mediates viral entry can be ignored. Vertical transmission of SARS-C0V-2 during delivery can occur through close contact with infected cervical secretions or perineal tissue. It is more important to note that the angiotensin-converting enzyme (ACE)-2, the SARS-CoV-2 receptor, is significantly elevated during pregnancy, which may contribute to susceptibility to SARS-CoV-2. The selection of drugs that demonstrate superior maternal and fetal safety should be considered for pregnant women with COVID-19.
Effect of chair-based exercise and vitamin d levels with hand grip strength in elderly woman
Authors: Dwi Ngestiningsih  , M Agung Wibowo Wicaksono  , Probosuseno  , Yuswo Supatmo  , Banundari Rachmawati
Published: January 2025

Introduction: The decrease in muscle mass in the elderly is due to a decrease in nerve function and muscle weakness due to the aging process, lack of physical activity, and malnutrition. This study aimed to determine the effect of chair-based exercise and vitamin D levels on the strength of the hand grip on elderly women.
Patients and methods: Cross-sectional study involving 50 female respondents (aged 64.94±5.42 years) The study sample was elderly individuals who met the inclusion criteria at the Semarang Elderly Posyandu. Respondents were divided into 2 groups, namely the chair-based sports group and the chair-based no-sport group for 8 weeks. Checking the strength of the hand grip using a grip dynamometer.
Results: No significant differences was found in hand grip score between chair-based and non chair-based exercise (p>0.05). Meanwhile significant difference was found in hand grip score between person with .
Conclusion: There is an influence of vitamin D levels on the strength of the hand grip in elderly women
Diagnostic value of qualitative, semiquantitative, and quantitative parameter of dynamic contrast-enhanced MRI in musculoskeletal tumor
Authors: Martadiani Elysanti Dwi , Sumadi I Wayan Juli , Putra I Wayan Gede Artawan Eka , Anggreni Faradilla Novita , Martono Budi , Primanda Yori , Nike Felicia , Triningsih
Published: January 2025

Background: Dynamic contrast-enhanced MRI (DCE-MRI) is a functional imaging technique using gadolinium contrast to enhance the tumor site. Several reported the diagnostic performance of DCE-MRI with various parameters used qualitatively, semi-quantitatively or quantitatively to differentiate benign and malignant soft tissue tumors. However, those evaluations were done separately. We investigated three DCE-MRI parameters simultaneously in determining musculoskeletal tumor malignancy: qualitative, semiquantitative and quantitative.
Method: This was a retrospective diagnostic study conducted in the Radiology Department of Prof. dr. IGNG Ngoerah Hospital Denpasar, Bali, in January – September 2022. We evaluated patients' qualitative, semiquantitative and quantitative DCE-MRI results of musculoskeletal tumors, also the histopathological result as the gold standard. We analyzed the ROC curve to predict the best cut-off value. The p-value <0.05 was significant.
Result: We found the qualitative DCE-MRI analysis showing AUC was 0.847. The qualitative parameters showed the best cut-off value with 68.4% sensitivity, 90.9% specificity, 92.9% PPV and 62.5% NPV. On the other hand, semiquantitative AUC was around 0.368 – 0.593, and quantitative parameters AUC was estimated at 0.380 – 0.612. Both semiquantitative and quantitative parameters did not produce the cut-off value.
Conclusion: Qualitative DCE-MRI parameters are a potential predictor for musculoskeletal malignancy.
Antioxidant potential effect combination of the bitter, red ginger, and turmeric extract with the DPPH method
Authors: Handayani  , Savitri Ardyarini Dyah , Puspitasari Renny Novi , Al Hajiri Aufar Zimamuz Zaman , Iryawan Rifky Dwi Aditya , Syukur Arina , Purwoko Miftah Ramadhan , Prawidya Syahrul Gusnaldi
Published: January 2025

Introduction: Bitter (Andrographis paniculata or Burm.f.), red ginger (Zingiber officinale var Rubrum Rhizoma), and turmeric (Curcuma domestica) are medicinal herbs of Asian countries used in many traditional medicinal. This study aimed to evaluate the potential antioxidant effect combination of bitter, red ginger, and turmeric extract with the DPPH (1,1-diphenyl-2-picrylhydrazyl) method.
Methods: This is an observational analytic study using the DPPH method to evaluate the potential antioxidant effect of four extracts, including bitter, red ginger, turmeric, and a combination of those three extracts called “SIJAKUN,” which stands for SambIloto, JAhe merah, and KUNyit in Indonesian. The antioxidant effect was evaluated by IC50 value. The comparable standard of antioxidants was Vitamin C.
Result: The IC50 value showed from the lowest to highest was 2.34, 3.75, 10.15, and 13.5 μg/mL occur in red ginger extract, “SIJAKUN” combination extract, turmeric extract, and bitter extract, respectively. The IC50 value of Vitamin C as a comparable compound was 13.2 μg/mL. The “SIJAKUN” combination extract was better than the single turmeric, bitter, and vitamin C extract, but not with red ginger extract.
Conclusion: The highest potential antioxidant effect with the DPPH method occurred in red ginger extract, even better than other extracts, such as combining the “SIJAKUN” extract based on the lowest IC50 value.
The effect of free peritoneal patch on fibroblast count and density of collagen on primary colon anastomosis in intraperitoneal infection in New Zealand White Rabbit model
Authors: Nugrahadi Adya Jati , Matulatan Fendy , Hariastawa I Gusti Bagus Adria
Published: January 2025

Background: In intraperitoneal infection or peritonitis, intestinal resection and anastomosis might result in severe morbidity and intestinal anastomosis leakage have been documented to be fatal. We aim to examined the effect of free peritoneal patch on fibroblast count and density of collagen on primary colon anastomosis in intraperitoneal infection.
Methods: This is an experimental study with randomized control trial design using New Zealand White Rabbit. We collected sample’s characteristic data (e.g., age, weight before and after intervention), fibroblast and collagen levels.
Results: The mean of fibroblast level in treatment group was higher than the mean of fibroblast level in control group but there was no significant difference between both group (P value=0.202). The medial collagen level in treatment group was 2, higher than the medial collagen level in control group that was 1 and there was significant difference between both group (P value = 0.010)
Conclusion: The free peritoneal patch on colon anastomosis in intraperitoneal infection can increase fibroblasts and collagen levels compared to those without free peritoneal patch.
The effect of freeze-dried human amnion on New Zealand rabbit tendon healing
Authors: Iustitiati Melissa Anita Ayu , Rizaliyana Sitti , Budi Agus Santoso
Published: January 2025

Background: Hand injury often causes acute morbidity and long-term disability. In the case of hand surgery, thirty percent of cases are from tendon injuries. The biomechanical strength of the tendon plays an important role in preventing post-repair rupture, where this strength is believed to be influenced by the number of strands of thread or the suturing technique used. In addition, biological materials such as amnion can reduce the risk of tendon adhesions and increase the biomechanical strength of the tendon itself.
Method: This study used an experimental randomized post-test-only control group research design. 18 male New Zealand rabbits had their right Achilles tendon severed, then divided into 2 groups, where group A was treated as a control while group B was treated with freeze-dried human amnion after tendon repair using braided suture (silk) material. On day 21, all rabbits were terminated and subjected to the macroscopic examination of tensile strength and microscopic examination of the number of fibroblasts and collagen density with hematoxylin-eosin staining. The test that will be carried out on each variable is the Mann-Whitney Test and T-test methods.
Result: The results showed that the average tensile strength in the treatment group was significantly greater than the control group (3.02±1.05 N/mm2 vs. 0.78±0.28 N/mm2, p<0.05). The mean number of fibroblasts in the treatment group was significantly greater than the control group (189.67±23.34 vs. 85.44±9.17, p<0.05). For the variable collagen density, 77.80% of the treatment group had collagen density with a score of 3 (p<0.05).
Conclusion: The application of freeze-dried human amnion after tendon grafting using braided suture material could increase tensile strength, number of fibroblasts, and collagen density in tendon healing.
Formation of woven bone in orthodontic tooth movement tension areas after giving Mangostin by expression of Runx-2 and IL-10
Authors: Arnawati Ida Ayu , Sudiana I Ketut
Published: January 2025

Background: Alveolar bone remodeling is very helpful in orthodontic treatment to prevent relapse after treatment is completed with new bone formation. Using natural materials that have a mechanism of action on the periodontal ligament and alveolar bone as a relapse prevention triggers osteogenesis with the formation of new bone in the tension area so that orthodontic treatment can be achieved maximally. This study aims to determine the formation of woven bone in the area attraction of orthodontic tooth movement after administration of Mangostin
Methods: A total of 30 male Wistar rats were divided into 3 groups, namely a negative control group (K1) without treatment, K2 and K3 a positive control group K(+), K2 a positive control group K(+), which was given a mechanical stressor without Mangostin administration and observed for 7 days, K3 positive control group K(+) which was given a mechanical stressor without Mangostin administration and observed for 14 days, K4 and K5 treatment group (P), K4 treatment group (P) where the group was given a mechanical stressor and Mangostin which was observed for 7 days, K5 the treatment group (P) where the group was given a mechanical stressor and Mangostin which was observed for 14 days. Dara was analyzed using SPSS version 23 for Windows.
Results: It was seen that the administration of Mangostin was very effective in increasing the expression of Runx-2, IL-10 and the formation of woven bone in the area of ​​higher tension than without the administration of Mangostin significantly (p<0.05). There was a significant increase (p<0.05) of Runx-2 and IL-10 in the treated group compared to the control group on day 7 and day 14, respectively.
Conclusion: The administration of Mangostin effectively prevented orthodontic relapse by increasing the expression of Runx-2 and Il-10 and accelerating the formation of woven bone in the tension area of ​​orthodontic movement.
Histopathological change of pancreas in hyperglycaemic wistar rats with nano extract of Coriandrum sativum l (ketumbar seeds) consumption
Authors: Sri Wahjuni  , Ida Ayu Raka Astitiasih  , Ni Made Puspawati  , Mustika Lahaya
Published: January 2025

Introduction: Coriandrum sativum L (ketumbar seeds) nano extract was prepared using chitosan as a nano extract framework and tripolyphosphate as a stabilizer by ionic gelatin method. This study aimed to reduce free radicals in streptozotocin-induced hyperglycaemic rats by administering Coriandrum sativum L nano extract as nano herbal
Methods: The surface topography of nano extract and characterization of zeta potential particle size was carried out using PSA (Particle Size Analyser). The ability of nano extract as anti-hyperglycaemic on streptozotocin-induced rats was tested using the randomized post-test only control group design.
Results: The result of the antihyperglycemic test on streptozotocin-induced rats showed that oral administration of the nano extract at a dose of 50 mg/Kg BW/day gave the best result for decreasing glucose blood, and MDA and increasing SOD levels in hyperglycaemic rats. The characterization of nano extract using PSA showed change here had been an encapsulation of bioactive substances from Coriandrum sativum L extract on the chitosan-tripolyphosphate absorption of NH, PO groups, and change histopathology pancreas of hyperglycaemic wistar rats. Characterization with PSA strongly supports nano extract as a delivery system for bioactive substances with a zeta potential of -25.80 mV and a particle size of 455.20 nm.
Conclusion: Coriandrum sativum L (ketumbar seeds) nano extract was prepared using chitosan had potential to reduce free radicals in streptozotocin-induced hyperglycaemic rats.
The determinants of medical student learning behavior that are associated with the outcome of the Indonesia Medical Doctor National Competency Examination: A review
Authors: Darmayani I Gusti Ayu Sri
Published: January 2025

Indonesia has implemented a National Competency Examination for medical graduates since 2014 called the Indonesian Doctors National Competency Examination (IMDNCE). The first component of the exam is multiple choice-based questions that use a computer-based testing method (MCQs-CBT) to assess the candidate's knowledge. The second component is Objective Structured Clinical Examinations (OSCE) to assess the performance of the candidate's clinical skills. The IMDNCE pass rate has never reached 100% because, in each exam period, 16-32% of examinees fail. CBT passes are also always lower than OSCE passes, and IMDNCE retakers mostly repeat CBT. The literature explaining the determinants of learning behavior and passing national exams is still limited. This study aims to identify the determinants of medical students' learning behavior in the national medical competency exam and their relationship to graduation outcomes. Learning behavior consists of two categories: the quality of learning and learning regulation. The conclusion is the determinant factors consist of internal and external factors. Internal factors include learning motivation and academic achievement, anxiety, and health conditions facing exams. External factors include environmental factors such as tutoring, family and peer support. These factors determine the learning behavior of medical students in the national medical competency exam in Indonesia, both in terms of quality and learning regulations.
Relations between the incidence of endometriosis and type 1 epithelial ovarian cancer at M Djamil Central Hospital of Padang Indonesia
Authors: Muhammad Syamel , Ghina Muthmainnah A Yasin
Published: January 2025

Introduction: The incidence of ovarian cancer is high and continues to increase yearly, especially in Padang. About 90% of them are the type of epithelial ovarian cancer. One of the predisposing factors of this cancer is endometriosis. Endometriosis has the same characteristics as malignant tumors, including the ability to invade other organs. It is known that endometriosis occurs in 7% -15% of women of childbearing age and has a variety of symptoms, making diagnosis difficult. This study aims to determine the relationship between the incidence of endometriosis and epithelial ovarian cancer in type 1 in Dr.M.Djamil Hospital Padang from 2017 to 2018.
Methods: This study is a cross-sectional analytic study. Subjects were obtained using a total sampling of ovarian cancer patients who went to the Obstetrics and Gynecology Dr. M.Djamil Hospital Padang from January 2017 - December 2018.
Results: The retrospective study used the data of epithelial ovarian cancer patients diagnosed at the Obstetrics and Gynecology Dr. M.Djamil Hospital Padang. The incidence of endometriosis was obtained at 8.3%, and the highest type of epithelial ovarian cancer is epithelial ovarian cancer type 1 (70.7%). The incidence of endometriosis had significantly increased in patients with ovarian cancer in type 1 with a significance value of 0,010.
Conclusion: The incidence of endometriosis was significantly associated with epithelial ovarian cancer type 1 because of p<0.05. Health agencies need extraordinary attention to prevent epithelial ovarian cancer endometriosis changes into type 1.
Effect of arabica Gayo coffee skin in repairing collagen damaged by UVB exposure
Authors: Lestari Wahyu , Hajar Sitti , Earlia Nanda , Asrizal Cynthia Wahyu , Ritonga Muhammad Arif
Published: January 2025

Introduction: Skin aging can be accelerated by UV exposure from the sun. UV exposure will increase oxidative stress to disturb collagen synthesis. To overcome the increase of oxidative stress, antioxidant compound from plants, such as coffee cascara pulp, can be utilized. Previous research proves that coffee cascara has the potential to overcome photoaging due to its content. This research aims to assess the benefits of topical cascara pulp arabica coffee extract cream on the number of collagen fibers thickness and density of Wistar rats (Rattus norvegicus) as a treatment for photoaging.
Method: 30 male Wistar rats (Rattus norvegicus) was divided to 5 groups. The negative control group (PN) was given base cream and the positive control (PP) was given vitamin C 3%. The treatment group was given cascara pulp arabica coffee extract cream with 5% concentration (P1), 7.5 concentration (P2), and 10% concentration (P3). The group was exposed to 840 mJ/cm2 of UVB in total for 4 weeks. Skin biopsy was done to assess the thickness and density of collagen fiber through histological examination using masson trichrome staining.
Result: The result shows significant differences (p<0.05) in collagen fiber thickness and density between the control and treatment groups. The topical application of cascara pulp arabica coffee extract cream gives higher collagen fiber density and thickness.
Conclusion: Applying cascara pulp arabica coffee extract cream can protect and repair dermal collagen of male wistar rats (Rattus norvegicus) exposed to UVB.
Single-Bundle vs. Double-Bundle ACL Reconstruction: Comparison of Joint Stability and Cartilage Integrity
Authors: Nelwan Bobby Natanel , Dilogo Ismail Hadisoebroto , Lubis Andri , Prasetyo Marcel , Mansyur Muchtaruddin
Published: January 2025

Introduction: The double-bundle ACL (DBACL) or single-bundle ACL (SBACL) reconstruction technique is a surgical technique to repair a ruptured ACL. Examination of the Lachman test, Pivot test, and rolimeter represent the anterior and rotational stability of the knee joint. In addition, MRI T2-map can provide an overview of joint cartilage integrity. Therefore, the best ACL reconstruction technique can be identified by analyzing joint stability and cartilage integrity changes.
Methods: A single-blind randomized clinical trial was conducted to determine whether DBACL reconstruction is superior to SBACL in subclinical joint stability and cartilage integrity measurements. Lachman test, pivot test, rolimeter, and the MRI T2-map assessment were evaluated on both groups. The normality tests on the characteristics of the subjects, joint stability, and cartilage integrity were conducted, followed by paired and unpaired statistical tests.
Results: Of the 43 patients analyzed, 22 were allocated to the SBACL group and 21 to the DBACL group. No significant difference was found on the Lachman test (p=0.849, p=0.126, and p=0.466), pivot test (p=0.877, p=0.678, p=0.904), and rolimeter (p=0.395, p=0.566, p =0.455), as well as MRI T2-map (p=0.145, p= 0.481, p= 0.114), and MRI T2-map semiquantitative (p=0.970, p =0.643, p=0.190) in both groups before, after three, and six months surgery. The mean value of the joint stability examination for each group improved from before, after three, and six months of surgery (p<0.05). The SBACL and DBACL groups had no significant difference in MRI T2-map (SBACL, p=0.055; DBACL, p=0.717) and MRI T2-map semiquantitative (SBACL, p=0.05; DBACL, p=0.06) at three and six months. Rolimeter examination did not significantly correlate with MRI T2-map.
Conclusion: DBACL reconstruction provides results that are equivalent to SBACL in Lachman tests, pivot tests, rolimeter, and MRI T2-map, and there is no significant relationship between joint stability and MRI T2-map after both reconstructions.
Comparison of agility between athletes of East Java Puslatda with asymptomatic plantar fasciitis and normal plantar fascia
Authors: Kennedy Bobby , Tinduh Damayanti , Wardhani Indrayuni Lukitra , Pawana I Putu Alit , Melaniani Soenarnatalina
Published: January 2025

Background: The chronic process of repeated microtrauma causes plantar fasciitis, with the main manifestation of pain that can lead to impaired stabilization and resistance of the foot. In chronic plantar fasciitis, there will be changes in vascularization and thickening of the plantar fascia. Both of these significantly impair foot function functional performance, including agility, static and dynamic balance. This study aims to compare the agility of the athletes of the East Java Puslatda with asymptomatic plantar fasciitis and normal plantar fascia.
Method: This study is an observational retrospective study using the medical records of athletes who underwent sports injury risk screening at the Sports Clinic RSUD dr. Soetomo Surabaya. Subjects were divided into asymptomatic plantar fasciitis (PFA) and normal plantar fascia (PFN) groups. The agility of both groups was measured using Agility “T” drill test tools and compared between the two groups.
Result: There were 98 subjects divided into 49 subjects in the asymptomatic plantar fasciitis group (25 males and 24 females aged 17-33 years) and 49 subjects in the normal plantar fascia group (20 males and 29 females aged 16-31 years). The average agility in the PFA group was 11.3 ± 0.13 seconds (9.62 seconds - 12.81 seconds), while in the PFN group, it was 11.76 ± 0.18 seconds (9.16 seconds - 16.34 seconds). There was no significant difference in agility between the two groups. Analysis according to each type of sport showed that apart from wushu and fencing, there was no significant difference in agility between the PFA group and PFN group. Analysis according to intrinsic factors showed a significant positive correlation with moderate strength between agility and gender.
Conclusion: There was no significant difference in agility between athletes with asymptomatic plantar fasciitis and athletes with normal plantar fascia.
Omega-3 intake and cachexia risk in cancer patients: systematic literature review
Authors: Putri Fildzah Karunia , Diba Nabilah Farah , Endah Budi Permana Putri
Published: January 2025

Introduction: Omega-3 is an essential fatty acid that is needed but the body cannot synthesize it. Omega-3s have good benefits for the body; such as can reduce the production of pro-inflammatory cytokines. Pro-inflammatory cytokines are one of the causes of cachexia in cancer patients. This study wanted to know about the intake of omega-3 either from food or supplements with the incidence of cachexia risk in cancer patients.
Method: A systematic literature review search was conducted using Search Engines, such as PubMed, Google Scholar, Science Direct, and DOAJ. The articles identified with the inclusion and exclusion criteria specified in the PICOS table. Then an assessment of the quality of the article was carried out using the JBI Critical Appraisal Tool.
Result: From 127 articles, only four studies that eligible to further analysis. In 4 literature studies, three studies used clinical research methods and a retrospective cohort study. Three literature studies show an association between omega-3 supplements with increased body weight, fat mass, and serum albumin. Only one literature study did not show an association between omega-3 supplements with increased body weight, body fat mass, serum albumin, decreased serum CRP, or serum IL-6. The forms of omega-3 supplementations consumed by most cancer patients are Fish Oil (FO) and Marine Phospholipids (MPL). FO with a 1-7 grams dose can increase body weight and serum albumin levels in cancer patients. MPL with a dose of 8.5 grams can also increase body weight.
Conclusion: This review found varying certainties of evidence of omega-3 supplementation to prevent cachexia. The recommendation for taking FO and MPL supplements is three times a day.
Comparison of Cost-Effectiveness Analysis (CEA) between sevoflurane inhalation anesthetic and Propofol Total Intravenous Anesthesia (TIVA) in craniotomy surgery: a literature review
Authors: Rehi Petrus Devi Doko
Published: January 2025

Link of Video Abstract: https://youtu.be/KigXgHWz0JU
 
Background: The common neuroaesthetics used for neurosurgery was inhalation of Sevoflurane and the newest, by continuous infusion of propofol called Total Intravenous Anesthetic (TIVA). Anesthesia procedures are one of the biggest healthcare expenditures in hospitals. Thus, finding the most effective and efficient anesthetic technique but in the same time can maintain patient safety is important. This literature review compares a cost-effective Sevoflurane and propofol TIVA analysis in craniotomy surgery.
Methods: This literature review was carried out by searching studies in three online databases consisted of PubMed, the Cochrane Library, and Google Scholar using the keywords "sevoflurane inhalation anesthetic", "propofol total intravenous anesthesia", "TIVA”, “craniotomy’, "cost-effective analysis", and “pharmacoeconomic”. Appropriate studies were then carried out through a narrative synthesis analysis.
Results: The assessment of cost-effective analysis in anesthesia is broadly divided into fixed commodities and various commodities. The analysis found the highest use of costs in the TIVA group and the lowest in the isoflurane inhalation group. The high cost in the TIVA group was caused by propofol being the most expensive compared to other inhalation agents such as isoflurane and Sevoflurane. Based on the average intraoperative anesthetic cost, it was also found that the anesthetic cost per patient was Rp. 957,870,- for the TIVA propofol group and Rp. 1,318,130,- for the sevoflurane group. Sevoflurane use for induction and maintenance of anesthesia resulted in a further modest decrease in costs (especially if fresh gas flow was reduced early), primarily through less drug waste.
Conclusion: The cost-effective analysis showed that Sevoflurane was less expensive than propofol. Yet, in terms of pharmacoeconomics, using TIVA propofol results in much fewer PONV episodes, unplanned hospital admissions, and patient lengths of stay, all of which improve pharmacoeconomic benefits.
Effect of intravenous methylprednisolone on the degree of hepatic ischemia/reperfusion injury in class III hypovolemic shock conditions performed continuous clamping in rats
Authors: Raharjo Suryo Wahyu , Lesmana Tomy
Published: January 2025

Link of Video Abstract: https://youtu.be/9qgtSz73eyE
 
Introduction: Pringle maneuver is the choice of hepatic inflow occlusion, when blood circulation is reopened, reperfusion will occur which causes ischemia/reperfusion injury (IRI) which will result in liver tissue damage. Methylprednisolone injection plays a role in deactivating kupffer thereby preventing inflammatory reactions that will reduce hepatic IRI. This study aims to determine intravenous methylprednisolone's effect on the degree of hepatic ischemia/reperfusion injury in class III hypovolemic shock where continuous clamping was performed.
Methods: Fifteen white rats (Rattus novergicus) underwent laparotomy, aspiration of blood up to 30% of the estimated blood volume (EBV) was carried out to prevent class III hypovolemic shock. The treatment group was given a single dose of 30 mg/kgBW methylprednisolone, while the control group received 30 mg/KgBW 0.9% sodium chloride. Then the Pringle maneuver continuous clamping is performed for up to 30 minutes and resuscitation of the aspirated blood back to the vena cava. On the 5th postoperative day, hepatic biopsy and total bilirubin were examined.
Results: Histopathological examination of the liver parenchyma as assessed by Suzuki's score showed a mean ± SD of the control group (K) 1.40 ± 0.91 while the treatment group (MP) 5.93 ± 1.03 with a p-value of 0.001 < 0.05. Total bilirubin results showed a mean ± SD of the control group (K) 0.21 ±  0.13 while the treatment group (MP) 0.22 ±  0.11 with a p-value of 0.477 > 0.05.
Conclusion: Intravenous methylprednisolone in rats that experienced ischemic/reperfusion injury after continuous clamping in class III hypovolemic shock did not reduce the degree of hepatic parenchymal damage assessed by Suzuki's histopathology score. However, it reduces the total bilirubin value.
Effect of platelet rich fibrin membrane on the expression of smooth muscle actin and transforming growth factor beta in corneal wound healing Pseudomonas aeruginosa keratitis patient: a literature review
Authors: Nurhidayat Bimanda Rizki , Nurwasis  , Evelyn Komaratih
Published: January 2025

One of the most common types of microbial keratitis is bacterial keratitis. The most common cause is Pseudomonas aeruginosa, which is more severe and causes local tissue damage. Fibrosis can form and cause vision loss, and perforation and spread to surrounding tissues in severe cases. Platelet-rich fibrin (PRF) membrane grafting is a new surgical technique that can optimize wound healing by preventing fibrosis formation by modifying Transforming Growth Factor Beta (TGF-β) expression and suppressing its overexpression. In addition, It preserves the structural integrity of the eye. It promotes the sustained release of growth factors, both of which are necessary for tissue regeneration and the induction of new collagen lamellae production. We suggest that in Pseudomonas aeruginosa keratitis, PRF may affect the expression of TGF- and Alpha Smooth Muscle Actin (-SMA). This literature review will reveal more details on how PRF can control inflammation and aid in Pseudomonas aeruginosa keratitis wound healing.
RETRACTED: From Books to Bedside: Analyzing Learning Strategies for Conceptual Medical Knowledge among Medical Students at Umm Al-Qura University, Saudi Arabia
Authors: Saleh Saleh Ahmed K. , Adly Heba Mohamed
Published: January 2025

Hereby, Bali Medical Journal stated that the article with details below:
ID        : 4773
Title     : From Books to Bedside: Analyzing Learning Strategies for Conceptual Medical Knowledge among Medical Students at Umm Al-Qura University, Saudi Arabia
Authors: Saleh Ahmed K. Saleh; Heba Mohamed Adly
This article has been retracted from Bali Medical Journal effectively from April 4th,2024.
Chronology and cause of retraction: Strong evidence of plagiarism.
This article was accepted by Bali Medical Journal because it had passed the pre-review screening (including plagiarism check), editorial evaluation, and double blind peer review process.
However, a report by authors from article entitled “How do medical students learn conceptual knowledge? High-, moderate- and low-utility learning techniques and perceived learning difficulties” authored by Anne Franz; Sebastian Oberst; Harm Peters; Ralph Berger; Ronja Behrend (https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03283-0), raised our concern about the article and the editorial board underwent several in depth evaluations regarding the plagiarism suspicion (comparison evidence from the authors of this journal attached). Indeed, the reviewers and editors found that there are strong signs of plagiarism in the aforementioned article, especially in the result section, in which the analytical values are exactly the same as the second article published in BMC. The editorial board considered that this is highly unusual and even by chance, deemed impossible. Therefore, the editorial board of Bali Medical Journal has decided to retract the article and published a letter of retraction including the evidence of plagiarism.
We hope that the readers understand the current circumstances of this article and read with caution. This response by Bali Medical Journal is conveyed as our commitment to uphold publication integrity.
Dermoscopic analysis of nevus pigmentosus
Authors: Mendrofa Ira , Putra Imam Budi , Jusuf Nelva K.
Published: January 2025

Introduction: A benign melanocytic skin condition known as nevus pigmentosus or nevomelanocytic is caused by the proliferation of melanocytes in the epidermis where pigment-producing cells congregate. Nevus can be found all over the body. The face, scalp, trunk, extremities and other areas frequently exposed to the sun are the most common places. Nevus is a special sign of a person in the location of the body as a sign of identity both clinically and dermoscopy. The aim of this study was to analyze the dermoscopy appearance of nevus pigmentosus.
Methods: Cross-sectional study using consecutive sampling methods on workers and students at the Universitas Sumatera Utara Hospital from July 2022 – May 2023. The researchers recorded basic data, and the diagnosis of nevus pigmentosus was established through anamnesis, sampling and dermatological examination.
Results: This research has received approval from the Research Ethics Commission of the Universitas Sumatera Utara and the Universitas Sumatera Utara Hospital. The number of nevus pigmentosus patients was 118 patients with 860 nevus. Most body locations were found in the superior extremities 315 nevus (36.6%) and face 222 nevus (25.8%). The color of the most frequently identified nevus was brown 821 (95.5%) with the highest pattern being reticular 675 (78.9%). Based on the pigment distribution of the nevus pigmentosus, 327 (38.3%) were uniform and central hyperpigmentation was 236 (27.4%), which was the most common.
Conclusion: The conclusion is that nevus pigmentosus is most commonly found on the superior extremities, brown, have a reticular pattern with uniform pigmentation.
Quality of Life after Cataract Surgery
Authors: Putri Sarah Eisya , Ahmad Ashraf  , Ichlas Nanang Afandi
Published: January 2025

Background: Cataracts are the common cause of blindness, causing disorders, limitations, and restrictions in patients’ physical, social, and daily activities. Cataract surgery can be performed as the only treatment. Objective assessment of the impact of cataracts, such as visual acuity, has not been able to describe overall visual function, so the subjective assessment is an overall quality of life assessment. This literature review aims to elaborate on successful factors for cataract surgery and factors related to the quality of life after cataract surgery.
Methods: This literature review conducted 21 research publications from 2011-2020 cited from some reputable sources using “cataract”, “cataract surgery”, “patient-reported outcome,” and “quality of life” as keywords.
Results: Successful factors for cataract surgery influenced by visual acuity, co-existing ocular comorbidities, and surgeon include surgical technique, surgeons’ skill, a complication of the surgery, and post-operative follow-up care. Visual acuity related to the quality of life after cataract surgery, such as productivity, psychosocial, education, and environment, must also be assessed. Quality of life after cataract surgery can be measured using questionnaires as patient-reported outcomes.
Conclusion: Cataract surgery significantly improved quality of life. Postoperative ocular outcomes are not the only target of surgery. Improved non-ocular outcomes, such as increased productivity, income, and even social status, need to be achieved to have a good quality of life after cataract surgery.
The effect of anthracycline chemotherapy on reducing left ventricular ejection fraction in breast cancer patients at Putri Bidadari Hospital Stabat
Authors: Rizka Adi , Millizia Anna , Wahyuni Hendra , Farziani Hayatul , Syahril Khairunnisa
Published: January 2025

Link of Video abstract: https://youtu.be/tAnMomyDnF0
 
Introduction: Breast cancer is the most common cancer and also the leading cause of death from cancer in women. Anthracycline chemotherapy is one of the most effective chemotherapy agents and is often used in the treatment of breast cancer. However, its use can cause cardiotoxicity which is characterized by a decrease in LVEF. Regulation of the Minister of Health of the Republic of Indonesia states that breast cancer patients who receive anthracycline chemotherapy must have an echocardiography examination after 2 cycles. This study aimed to assess the effect of anthracycline chemotherapy on reducing LVEF in breast cancer patients.
Methods: This study was an observational study with a cross-sectional design. The data used was secondary data in the form of LVEF values of breast cancer patients before being given anthracycline dose chemotherapy with 60 mg/m2 of body surface area (BSA), after being given 2 cycles and after 4 cycles with a total of 22 respondents. Data were analyzed using the Paired T-test. The limitations of this study were small sample size (22 patients) and study was limited to only one hospital.
Results: The results of this study obtained p values for LVEF 1-LVEF 2 of 0.748 and LVEF 2-LVEF 3 of 0.215 with an average decrease in LVEF of 0.318% for LVEF 1-LVEF 2 and 1.409% for LVEF 2 and LVEF 3 with p value 0.000 and 0.001.
Conclusion: Based on the results of this study it is known that there are differences in LVEF values before and after administration of chemotherapy but there are no significant differences and cannot be classified as cardiotoxicity so that echocardiographic examinations in patients in close proximity are not effective enough to detect anthracycline-induced cardiotoxicity.