bluuebunny/crossref_metadata_2025 huggingface dataset:
Αλληλεπίδραση παραγόντων συναισθηματικής νοημοσύνης και στυλ ηγεσίας στα διοικητικά στελέχη του σύγχρονου ναυτιλιακού επιχειρηματικού κόσμου
Authors: Θεοδωρίκα Ελένη
Published: July 2022

Trait Emotional Intelligence (TEI) is a research construct that has attracted widespread attention from both Industrial Psychology and Management Science researchers. As to provide an updated and evidence-based picture on the effects of Trai-El in the Shipping workplace, this study examined both the qualitative and quantitative relationships between TEl (TEIQue) and Leadership Styles (MLQ) variables, in a typical shipping corporate environment. Two instruments were used to collect research data relevant to the study. The Trait Emotional Intelligence Questionnaire (TEIQue-Petrides & Furnham, 2003) measuring trait emotional intelligence; and the Multifactor Leadership Questionnaire (MLQ-Avolio & Bass, 1991), measuring leadership style, as well as six (6) demographic questions were completed by the participants (N=246). Using a qualitative analytic approach, the total sample was analyzed by utilizing One-Way ANOVA for both TEI and MLQ per demographic variable (Gender, Hierarchy level & Experience level). Also, a quantitative approach was followed, where trait emotional intelligence orientation was matched and examined with the specific leadership style, to draw conclusions on the possible relationship and/or inter-relationship between the two constructs (TEIQ-MLQ). The regression results revealed that Trait Emotional Intelligence (TEI) was not a predictor of Transformational Leadership style and that it has no significant associations with either Transactional Leadership or Laissez Faire Leadership styles. The stepwise regression analysis revealed that specific factors of the Trait-EI construct are predictors of either Transformational Leadership style (TEI_WellBeing, TEI_Self-Control, TEI_Self_Energy/Motivation/Adaptability) or Transactional Leadership style (TEI_Sociability). In addition, the analysis showed that TEI_Self-Energy/Motivation/Adaptability and TEI_Sociability TEI are negative predictors of the Laissez Faire Leadership style. Moreover, the regression findings of the current study between Trait-EI and Job-related outcomes, call for future quantitative research on either the mediation role or moderation role of the Trait-EI -if any-between the MLQ variables and the variables of Job-Related Outcomes (Effectiveness, Efficiency and Job Satisfaction).
Η Συνεισφορά της χρήσης ασκήσεων αποκλεισμού της αιματικής ροής άνω άκρου στη φυσικοθεραπευτική αντιμετώπιση ασθενών με έξω επικονδυλίτιδα του αγκώνα
Authors: Καρανάσιος Στέφανος
Published: July 2022

Η θεραπευτική άσκηση με ή χωρίς επιπρόσθετες φυσικοθεραπευτικές τεχνικές είναι η πρώτη επιλογή θεραπείας στους ασθενείς με πλάγια έξω τενοντοπάθεια αγκώνα (ΠΕΤΑ). Ωστόσο, η αποτελεσματικότητά της είναι μικρή και επιπρόσθετα ένας τύπος άσκησης δεν φαίνεται να υπερέχει έναντι άλλων. Τα προγράμματα άσκησης αντίστασης χαμηλού φορτίου με περιορισμό αιματικής ροής (ΠΑΑΧΦ-ΠΑΙΜΡ) προτείνονται ως χρήσιμη εναλλακτική στην αποκατάσταση όταν οι συμβατικές ασκήσεις αντενδείκνυνται ή πρέπει να αποφεύγονται λόγω πόνου.Στα πλαίσια της παρούσας διδακτορικής διατριβής υλοποιήθηκε μια μελέτη τυχαιοποιημένων μετρήσεων όπου ελέγχθηκε η επίδραση της θέσης και άλλων προγνωστικών παραγόντων στην εύρεση της αρτηριακής αποφρακτικής πίεσης (ΑΑΠ) του άνω άκρου με σκοπό την τυποποίηση της μεθόδου άσκησης με ΠΑΙΜΡ. Επίσης, πραγματοποιήθηκε μια συστηματική ανασκόπηση για την αξιολόγηση της διαγνωστικής ακρίβειας των δοκιμών εξέτασης της ΠΕΤΑ και ακολούθησε μια τυχαιοποιημένη ελεγχόμενη δοκιμή για την αξιολόγηση της επίδρασης ενός ΠΑΑΧΦ-ΠΑΙΜΡ σε σύγκριση με ΠΑΑΧΦ με εικονικό ΠΑΙΜΡ σε ασθενείς με ΠΕΤΑ. Η ένταση του πόνου, ο βαθμός αναπηρίας, η δύναμη λαβής χωρίς πόνο, η δύναμη κάμψης/έκτασης αγκώνα και το πάχος του τένοντα αναλύθηκαν χρησιμοποιώντας μοντέλα μικτών επιδράσεων. Το ποσοστό επιτυχίας και η αυτό-αντίληψη της βελτίωσης αναλύθηκαν χρησιμοποιώντας λογιστική παλινδρόμηση.Υπάρχει σημαντική επίδραση της θέσης του σώματος σε σχέση με την ΑΑΠ του άνω άκρου (καθιστή > ύπτια, ύπτια > όρθια, p<0,031). Για τη διάγνωση της ΠΕΤΑ η δοκιμή Cozen έχει την υψηλότερη ευαισθησία (91%). Επίσης, η διαφορά στη δύναμη λαβής μεταξύ κάμψης και έκτασης του αγκώνα έχει υψηλή ευαισθησία (78%-83%) και ειδικότητα (80%-90%). Από τις απεικονιστικές μεθόδους η ελαστογραφία και η μαγνητική τομογραφία έδειξαν την υψηλότερη ευαισθησία (75%-100%) και ειδικότητα (85%-96%).Στην κύρια μελέτη συμμετείχαν 46 ασθενείς με ΠΕΤΑ (μέση ηλικία: 45,2 έτη, τυπική απόκλιση: 8,4). Βρέθηκαν στατιστικά σημαντικές αλληλεπιδράσεις υπέρ του ΠΑΑΧΦ-ΠΑΙΜΡ με μέτρια έως μεγάλα μεγέθη επίδρασης στην ένταση πόνου, στο βαθμό αναπηρίας, στηδύναμη λαβής χωρίς πόνο και στη δύναμη κάμψης και έκτασης αγκώνα. Ένα σημαντικά μεγαλύτερο ποσοστό επιτυχίας της θεραπείας (82%) καταγράφηκε στην ομάδα ΠΑΑΧΦ-ΠΑΙΜΡ στις 6 και 12 εβδομάδες επανελέγχου σε σύγκριση με την ομάδα με εικονικό ΠΑΙΜΡ (43% και 52%, αντίστοιχα).Συνολικά, ένα ΠΑΑΧΦ-ΠΑΙΜΡ μπορεί να βελτιώσει σημαντικά τον πόνο και τη λειτουργικότητα, τη μυϊκή δύναμη και την αυτο-αντίληψη της υγείας των συγκριτικά με ένα ΠΑΑΧΦ με εικονικό ΠΑΙΜΡ σε ασθενείς με ΠΕΤΑ. Λαμβάνοντας υπόψη την κλινικά σημαντική βελτίωση της λειτουργικότητας μεταξύ των ομάδων και την έλλειψη ανεπιθύμητων ενεργειών, το ΠΑΑΧΦ-ΠΑΙΜΡ δύναται να αποτελέσει μια πολύτιμη παρέμβαση για τη βελτίωση της αποκατάστασης στην παρούσα πάθηση.
Ο μικρόκοσμος στο δημοτικό – κάνοντας «ορατά» τα μη-ορατά σωματίδια της ύλης
Authors: Γκικοπούλου Ουρανία
Published: July 2022

Numerous studies support the educational model of microcosm as a useful tool for understanding and interpreting macroscopic phenomena. Consequently, an international attempt is made to apply educational approaches of this model or of the particulate nature of matter, as most commonly reported in the international bibliography. However, introducing the model of microcosm seems to be a difficult and long-lasting issue as it involves non-intuitive ideas and it refers to a scale that students are unable to understand using their senses. For this reason, a worldwide effort to find the best educational approach for students as young as possible is currently attempted. In this study, an intervention was implemented, attempting to introduce the model of microcosm to primary education by applying analogies, sequential enlargements of objects, simultaneous macroscopic and microscopic imaging and dynamic simulations of microcosm, in order to address the difficulties of the non-intuitive ideas and especially of the invisible particles that compose matter. The research was focused on whether primary school students were capable, after the proposed intervention, of understanding this model and apply it in the explanation of macroscopic phenomena. The sample consisted of 50 students in the 5th grade. The results showed that students of this age are in a position to understand the model of microcosm thus, additionally facilitating the understanding and explanation of the macroscopic phenomena (e.g. physical change).
Από χώρα σε χώρα: αντιξοότητες και ομαλή προσαρμογή. Εμπειρίες παιδιών προσφύγων
Authors: Γρηγορόπουλος Ηρακλής , Ντόβα Μαρία
Published: July 2022

Σκοπός της παρούσας έρευνας ήταν η  διερεύνηση  των αντιξοοτήτων που αντιμετώπισαν ή/και συνεχίζουν να αντιμετωπίζουν τα συμμετέχοντα παιδιά και των παραγόντων εκείνων που (για τα ίδια) λειτούργησαν ή/και συνεχίζουν να  λειτουργούν ως παράγοντες ομαλής προσαρμογής (προστατευτικοί παράγοντες- ψυχική ανθεκτικότητα). Η κατανόηση της εμπειρίας του κάθε μεμονωμένου πρόσφυγα είναι ιδιαίτερα σημαντική για τον σχεδιασμό των υπηρεσιών (όχι μόνο υγείας)  στο πλαίσιο που ακολουθεί τη φυγή. Χρησιμοποιήθηκε ποιοτική μεθοδολογία. Συμμετείχαν 15 μαθητές/τριες (επτά κορίτσια)  από πρόγραμμα ένταξης στο Ελληνικό δημοτικό σχολείο σε περιοχή της κεντρικής Μακεδονίας. Η ηλικία τους κυμαινόταν από τα 6 έως τα 12 έτη. Η συλλογή δεδομένων πραγματοποιήθηκε με ημιδομημένες συνεντεύξεις και η επεξεργασία τους με βάση την Ερμηνευτική Φαινομενολογική Ανάλυση (IPA). Από τη συστηματική ανάλυση των αφηγήσεων προέκυψαν 3  κεντρικές θεματικές και οι υπο-θεματικές τους , οι οποίες οδηγούν στη νοηματοδότηση της εμπειρίας των παιδιών που συμμετείχαν. Συνολικά, η ανάλυση των δεδομένων ανέδειξε το γεγονός ότι η μετακίνηση σε μια νέα χώρα υπέβαλε τα παιδιά της συγκεκριμένης έρευνας σε πιεστικά γεγονότα για την αντιμετώπιση των οποίων σημαντικό ρόλο έπαιξε η αξιοποίηση των προσωπικών τους δυνατοτήτων.
UJI KANDUNGAN FORMALIN PADA AYAM BROILER YANG DI JUAL DI PASAR TRADISIONAL DAN PASAR MODERN DI WILAYAH DEPOK SLEMAN YOGYAKARTA
Authors: Kristiani Eva Runi , Febriani Heni , Franklin Quezia
Published: July 2022

Ayam merupakan salah satu sumber protein hewani yang banyak dikonsumsi masyarakat dan sangat dibutuhkan sebagai sumber gizi untuk kesehatan masyarakat, produk tersebut menjadi berbahaya bagi kesehatan masyarakat bila tidak terjamin keamanannya seperti penggunaan bahan tambahan (kima dan alami) untuk pengawet, termasuk formalin. Penelitian ini bertujuan untuk mengetahui ada tidaknya kandungan formalin pada ayam broiler yang dijual dipasar tradisional dan pasar modern di wilayah Depok, Sleman, Yogyakarta. Jenis Penelitian yang digunakan adalah penelitian eksperimental dengan pendekatan Â deskriptif. Pelaksanaanya dilakukan di Laboratorium STIKES Wira Husada Yogyakarta. Sampel diambil dengan metodeÂ  teknikÂ  cluser random sampling. Jumlah sampel yang diambil sebanyak 27 sampel dari pasar tradisional dan pasar modern wilayah Depok Sleman Yogyakarta. Sampel kemudian dianalisi menggunakan reagen FeCL3. Hasil penelitian menunjukan bahwa 6 dari 27 sampel ayam broiler tersebut positif mengandung formalin.Â Kata Kunci: Analisis Kualitatif, Formalin, Ayam broiler.
HUBUNGAN ANTARA PENGETAHUAN DAN SIKAP TERHADAP PENCEGAHAN FOOD BORNE DISEASE PADA SISWA SEKOLAH DASAR
Authors: Suryani Dyah
Published: July 2022

Food safety is an important public health problem because more and more cases are reported related to the consumption of unsafe food. Inadequate knowledge about food safety among consumers, especially children, can increase the risk of health problems related to food safety, especially foodborne illness. To prevent foodborne illness among children, behavior that ensures the safety of food purchased and consumed by students is an important factor. The purpose of this study was to determine the relationship between knowledge and attitudes with food borne disease prevention behavior in 4th and 5th grade students of Triwidadi Pajangan Bantul State Elementary School. This study was an observational study with a cross-sectional approach. The population in this study were students in grades 4 and 5 of the State Elementary School (SDN) Triwidadi Pajangan Bantul, totaling 35 students. Samples are taken in totality samples. Data was collected using a knowledge, attitude and behavior questionnaire. Data analysis using chi-square test. There is a relationship between knowledge about the causes and prevention of food borne disease with food borne disease prevention behavior (p value = 0.027) in 4th and 5th grade students of Triwidadi Bantul Pajangan Bantul. There is no relationship between attitudes about the causes and prevention of food borne disease with food borne disease prevention behavior (p value = 0.082) in 4th and 5th grade students of Triwidadi Bantul Pajangan Bantul. There is a relationship between knowledge and food borne disease prevention behavior and there is no relationship between attitude and food borne disease prevention behavior in 4th and 5th grade students of Triwidadi Bantul Pajangan Bantul.
HUBUNGAN TINGKAT PENGETAHUAN DAN SIKAP PENGELOLA DENGAN KEADAAN SANITASI TOILET UMUM DI PANTAI PARANGTRITIS, BANTUL, DIY
Authors: Faizal Rangkuti Ahmad , Purnamasari Dewi
Published: July 2022

Latar Belakang: Toilet umum merupakan fasilitas vital bagi ruang publik. Ketersediaan sarana sanitasi tersebut bertujuan agar wisatawan dapat dengan mudah menikmati sarana yang sehat. Fasilitas toilet umum sering terabaikan baik ketersediaan maupun kualitas kebersihannya di beberapa kawasan wisata yang telah dilengkapi dengan fasilitas toilet umum. Permasalahan yang sering muncul adalah rendahnya tingkat kebersihan akibat pengelolaan yang kurang baik. Tingkat pengetahuan dan sikap pengelola terkait sanitasi toilet umum sangat penting, agar tercipta sanitasi toilet yang bersih dan sehat. Tujuan penelitian ini adalah untuk mengetahui hubungan tingkat pengetahuan dan sikap pengelola dengan keadaan sanitasi toilet umum di Pantai Parangtritis, bantul, DIY.Metode: Jenis penelitian yang digunakan pada penelitian ini adalah observasional analitik dengan rancangan cross sectional. Sampel dalam penelitian ini berjumlah 38 pengelola dengan 80 toilet umum menggunakan teknik total sampling. Instrumen yang digunakan penelitian ini adalah kuesioner dan check list. Analisis data menggunakan analisis univariat dan bivariat yaitu uji chi square.Hasil: Hasil analisis univariat pengetahuan kategori tinggi sebanyak 22 responden (55,3%). Sikap kategori tinggi sebanyak 22 responden (57,9%). Sanitasi toilet umum kategori tidak laik sehat sebanyak 47 toilet (58,8%). Analisis bivariat didapatkan nilai nilai p> 0,05 (p=0,821) untuk tingkat pengetahuan pengelola. Nilai p> 0,05 (p=0,410) untuk sikap pengelola.Kesimpulan: Tidak ada hubungan antara tingkat pengetahuan dan sikap pengelola dengan keadaan sanitasi toilet umum di pantai Parangtritis, Bantul, DIY.Â
GAMBARAN PERSENTASE PENURUNAN ANGKA KUMAN GEL HAND SANITIZER DAN TISU BASAH ANTISEPTIK PADA TELAPAK TANGAN
Authors: Musfirah Musfirah
Published: July 2022

Diarrhea is the third order of disease in the Southeast Asian region that causes death in adolescents. Handwashing behavior is really important in preventing diarrhea in Indonesia. Antiseptic wet wipes and hand sanitizer gel are an acceptable alternative for washing hands with soap and air. The study aimed to determine the percentage reduction of hand sanitizer gel and wet-wipes antiseptic at the quantity of hand germs. This study used a quantitative descriptive study with a true experiment research design with a randomized pretest-posttest control group design. The research subjects were one respondent who will conduct 6 steps with any treatment 4 times of repetition. The results of univariate analysis showed that hand sanitizer â€œbrand Bâ€ and antiseptic wet tissue â€œbrand Bâ€ had a percentage reduction in the highest number of germs due to the existing treatment, respectively 80,49% and 73,55%. The percentage reduction of the germs number on the palms was found in hand sanitizer gel â€œbrand Bâ€ and antiseptic wet wipes â€œbrand Bâ€.
HUBUNGAN PENGETAHUAN, SIKAP, SARANA DAN JENIS KELAMIN DENGAN PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) DI ASRAMA RIAU, YOGYAKARTA
Authors: Suryani Dyah , Syahputra Ozy
Published: July 2022

Clean and healthy living behavior is behavior based on the desire, willingness, and ability of people to help themselves in the health sector and to be able to play an active role in health activities. In terms of equitable development with a health perspective, it includes all groups of society, both groups of children and groups of adults: the factor that can influence and attitudes. There are still residents in the Riau Yogyakarta Student Dormitory who do not know how to live clean and healthy, and the prerequisites support a clean and healthy lifestyle. The purpose of this study was to analyze the relationship between knowledge, attitudes, facilities, and gender for clean and healthy living behavior (CHLB) in Riau Yogyakarta Dormitory. This study used a cross-sectional study. The population of this study was residents of the Riau Yogyakarta student dormitory. The sampling technique was carried out by total sampling (41 respondents). The research instrument was a questionnaire of knowledge, attitudes, facilities, sex, and CHLB. Data analysis using univariate analysis and bivariate analysis using Chi-square test. The results of the bivariate analysis showed that there was a relationship between knowledge and CHLB of dormitory residents p= 0,002, there was a relationship between attitudes and CHLB of dormitory residents p= 0,000, there was a relationship between facilities and CHLB of dormitory residents p= 0,000, and there was a relationship between sex and CHLB dorm residents p= 0,005. There is a relationship between knowledge, attitudes, facilities, and gender with CHLB dormitory residents in Riau Yogyakarta.
PENGARUH WARNA OVITRAP TERHADAP JUMLAH TELUR NYAMUK Aedes aegypti
Authors: Darwamati Linda Putri , Sukesi Tri Wahyuni
Published: July 2022

Aedes aegypti mosquito is a vector of the dengue virus which causes dengue hemorrhagic fever (DHF). Efforts that can be made to overcome the spread of dengue fever by controlling vectors, one of which is by breaking the vector life cycle using an egg trap (ovitrap). This study aims to determine the ability of Aedes aegypti mosquitoes to lay eggs on ovitrap color differences, determine the ovitrap color with the highest number of Aedes aegypti mosquito eggs, determine the difference in ovitrap color to the number of trapped Aedes aegypti mosquito eggs and determine the average difference between various ovitrap colors in Ahmad Dahlan University Rearing Laboratory from July to August 2020. This research method is One Group Design. Three repetitions were carried out with a plastic bottle that was painted black, transparent, green, blue, purple and yellow. The 90 blood-saturated mosquitoes were put into three cages containing various colors of the ovitrap which had been given water and filter paper to place the eggs. The results showed that the Aedes aegypti mosquito would lay eggs on each ovitrap color and the number of mosquito eggs was mostly found on black ovitrap as many as 2978 eggs. Anova analysis showed that there was a significant difference in each ovitrap color to the number of trapped mosquito eggs and Benferroni's Post Hoc analysis showed that there was a significant difference between black means ovitrap with purple ovitrap and black and yellow color ovitrap
HUBUNGAN TINGKAT PENGETAHUAN, SIKAP DAN KEPEMILIKAN JAMBAN DENGAN KEBIASAAN BUANG AIR BESAR SEMBARANGAN (BABS) DIDUSUN REJOSARI DESA SERUT KECAMATAN GEDANGSARI KABUPATEN GUNUNG KIDUL
Authors: Rangkuti Ahmad Faizal , Rizkie Dynnia Anindilla
Published: July 2022

Open defecation free (ODF) is a dangerous activity both for oneself and the community.Toilet ownership is one indicator of a clean and healthy life behavior program. Open defecation free can be influenced by factors such as the level of knowledge, attitudes, and ownership of latrines.The purpose of this study was to determine the relationship between the level of knowledge, attitudes and ownership of latrines with open defecation (ODF) in Rejosari, Serut, Gedangsari, Gunung Kidul. Research methods used cross-sectional designs. Technique sampling used a cluster random sampling. Total samples were 82 households. Data analysis used chi square test. Based on the results of the univariate test, 18 respondents (22%) had a lack of level of knowledge, 64 respondents (78%) had a good level of knowledge. Not a good attitude as many as 15 respondents (18.3%) and who have a good attitude as many as 67 respondents (81.7%). Respondents who did not have a toilet were 14 respondents (17.1%) and those who had a toilet were 68 respondents (82.9%). Defecation habits are not good as many as 39 respondents (47.6%) and those who have good bowel habits are 43 respondents (52.4%). Bivariate analysis found the value of RP = 2.222 (95% CI: 1.523-3.224) and the value of p <0.05, the value (p = 0.002) for the level of knowledge. RP = 1,985 (95% CI: 1,350, -2,920) and p value <0.05, value (p = 0.013) for attitude. Rp. 2,159 (95% CI: 1,502-3,102) and p value <0.05, value (p = 0.004) for latrine ownership. There was a relationship between the level of knowledge, attitude and ownership of latrines with open defecation habits (ODF).
PENERAPAN PRINSIP HIGIENE SANITASI DENGAN KEBERADAAN HAZARD BIOLOGIS PADA PERALATAN DI KANTIN UNIVERSITAS
Authors: Musfirah Musfirah , Rahayu Atikah , Agustin Helfi
Published: July 2022

Cafetaria in university must meet the nutritious and healthy snacks for students. The quality of healthy and nutritious food is influenced by hygienic, good sanitation and free-hazard contamination aspects on the canteen management. Poor sanitation and hygiene utensils and storage management can increase food contamination.This study aimed to determine the association of implementation of food and hygiene sanitation with the biological hazard on eating utensils. This study used cross-sectional design  and  was conducted in May 2017. The number of canteen sample were 9 canteen and 15 food handlers. The data were collected by microbiological quality checks on tableware and cookware which were often used by the food handlers in food management, observation sheet of sanitary conditions of eating utensils, and questionnaires to find out the implementation of food sanitation hygiene in the canteen. The analytical statistic method used Fisher test. The results study indicate the implementation of hygiene sanitation principle was not associated  with the existence of biological hazard of germs in  tableware (p = 0,538) and cookware (p = 0,476) variable. Knowledge and practice of food safety needs to be increased through training on food security and food sanitation hygiene among food handlers.
Maximum Energy Extraction in Partially Shaded PV Systems Using Skewed Genetic Algorithm: Computer Simulations, Experimentation and Evaluation on a 30 kW PV Power Plant
Authors: Puthusserry Gireesh V. , Sundareswaran Kinattingal , Simon Sishaj P. , Krishnan G. Satheesh
Published: July 2022

This paper presents an improved Genetic algorithm (GA) for Maximum Power Point Tracking (MPPT) in shaded Photovoltaic (PV) power generation systems. The proposed GA uses shrinking population wherein fitter chromosomes are retained for next generations while lesser-performing chromosomes are removed from the population sequentially. This methodology reduces convergence time while retains major advantages of GA. The method is explained lucidly and then computer simulations and experimental results on a prototype fabricated in the laboratory are presented. The practical feasibility of the new method is then showcased by applying the new theory on a 30-kW Photovoltaic (PV) power plant established in an educational institution premise. The PV plant undergoes partial shading conditions (PSC) during morning and afternoon hours due to branches of tall trees grown around the school building. The MPPT algorithm employed in the PV plant is Perturb and Observe (P&O) which fails to track global power peak at several shading conditions leading to loss of energy. The realistic shading patterns occurring on the PV plant were recorded and the new method is shown to exhibit enhanced energy yield.
Design and Validation of Quantum Key Management System for Construction of KREONET Quantum Cryptography Communication
Authors: Shim Kyu-Seok , Kim Yong-hwan , Sohn Ilkwon , Lee Eunjoo , Bae Kwang-il , Lee Wonhyuk
Published: July 2022

As it has been recently proven that the public key-based RSA algorithms that are currently used in encryption can be unlocked by Shor’s algorithm of quantum computers in a short time, conventional security systems are facing new threats, and accordingly, studies have been actively conducted on new security systems. They are classified into two typical methods: Post Quantum Cryptography (PQC) and Quantum Key Distribution (QKD). PQC aims to design conventional cryptography systems in a more robust way so that they will not be decrypted by a quantum computer in a short time whereas QKD aims to make data tapping and interception physically impossible by using quantum mechanical characteristics. In this paper, we design a quantum key management system, which is most crucial for constructing a QKD network and analyze the design requirements to apply them to Korea Research Environment Open NETwork (KREONET). The quantum key management system not only manages the lifecycle, such as storage, management, derivation, allocation, and deletion of the symmetric key generated in QKD but also enables many-to-many communication in QKD communication based on the key relay function and P2P communication to overcome the limitation of distance, which is a disadvantage of QKD. We have validated the designed quantum key management system through simulations to supplement the parts that were not considered during the initial design.
Explainable emphysema detection on chest radiographs with deep learning
Authors: Çallı Erdi , Murphy Keelin , Scholten Ernst T. , Schalekamp Steven , van Ginneken Bram
Published: July 2022

We propose a deep learning system to automatically detect four explainable emphysema signs on frontal and lateral chest radiographs. Frontal and lateral chest radiographs from 3000 studies were retrospectively collected. Two radiologists annotated these with 4 radiological signs of pulmonary emphysema identified from the literature. A patient with ≥2 of these signs present is considered emphysema positive. Using separate deep learning systems for frontal and lateral images we predict the presence of each of the four visual signs and use these to determine emphysema positivity. The ROC and AUC results on a set of 422 held-out cases, labeled by both radiologists, are reported. Comparison with a black-box model which predicts emphysema without the use of explainable visual features is made on the annotations from both radiologists, as well as the subset that they agreed on. DeLong’s test is used to compare with the black-box model ROC and McNemar’s test to compare with radiologist performance. In 422 test cases, emphysema positivity was predicted with AUCs of 0.924 and 0.946 using the reference standard from each radiologist separately. Setting model sensitivity equivalent to that of the second radiologist, our model has a comparable specificity (p= 0.880 andp= 0.143 for each radiologist respectively). Our method is comparable with the black-box model with AUCs of 0.915 (p= 0.407) and 0.935 (p= 0.291), respectively. On the 370 cases where both radiologists agreed (53 positives), our model achieves an AUC of 0.981, again comparable to the black-box model AUC of 0.972 (p= 0.289). Our proposed method can predict emphysema positivity on chest radiographs as well as a radiologist or a comparable black-box method. It additionally produces labels for four visual signs to ensure the explainability of the result. The dataset is publicly available athttps://doi.org/10.5281/zenodo.6373392.
Chondrosarcoma patient characteristics, management, and outcomes based on over 5,000 cases from the National Cancer Database (NCDB)
Authors: Ottesen Taylor D. , Shultz Blake N. , Munger Alana M. , Amick Michael , Toombs Courtney S. , Friedaender Gary E. , Grauer Jonathan N.
Published: July 2022

Introduction

Chondrosarcoma, although relatively uncommon, represents a significant percentage of primary osseous tumors. Nonetheless, there are few large-cohort, longitudinal studies of long-term survival and treatment outcomes of chondrosarcoma patients and none using the National Cancer Database (NCDB).

Methods

Chondrosarcoma patients were identified from the 2004–2015 NCDB datasets and divided on three primary tumor sites: appendicular, axial, and other. Demographic, treatment, and long-term survival data were determined for each group. Multivariate Cox analysis and Kaplan-Meier survival curves were generated to assess long-term survival over time for each.

Results

In total, 5,329 chondrosarcoma patients were identified, of which 2,686 were appendicular and 1,616 were axial. Survival was higher among the appendicular cohort than axial at 1-year, 5-year, and 10-year (89.52%, 75.76%, and 65.24%, respectively). Multivariate Cox analysis identified patients in the appendicular cohort to have significantly greater likelihood of death with increasing age category, distant metastases at presentation, and male sex (p<0.001 for each). Best outcomes for seen for those undergoing surgical treatment (p<0.001). Patients in the axial cohort were with increased likelihood of death with increasing age category and distant metastases (p<0.001), while surgical treatment with or without radiation were associated with a significant decrease (p<0.001). Kaplan-Meier survival analysis showed worst survival for the axial cohort (p<0.001) and patients with distant metastases at presentation (p<0.001). Survival was not significantly different between older (2004–2007) and more recent years (2012–2016) (p = 0.742).

Conclusions

For both appendicular and axial chondrosarcomas, surgical treatment remains the mainstay of treatment due to its continued superiority for the long-term survival of patients, although advancements in survival over the last decade have been insignificant. Presence of distant metastases and axial involvement are significant, poor prognostic factors perhaps because of difficulty in surgical excision or extent of disease.
Effects of transcutaneous tibial nerve stimulation on females with overactive bladder syndrome in multiple sclerosis a protocol for a systematic review and meta-analysis
Authors: Tu Huan , Li Ning , Liu Wanna , Fan Zhonghe , Kong Dezhi
Published: July 2022

Background

Overactive bladder (OAB) is a problem that increasingly affects adults and the elderly, especially women. It may affect quality of life, ability to participate and overall wellbeing. Transcutaneous tibial nerve stimulation (TTNS) is a form of neuromodulation involving the use of electrical impulses to address urinary symptoms. There are many randomized controlled trials that have shown that TTNS is effective at treating overactive bladder. In recent years, TTNS has gained increasing attention for this condition. But its effect in females remains controversial and evidence is lacking. Therefore, the main purpose of this study will be to systematically evaluate the effect of TTNS on females with OAB in Multiple sclerosis (MS) by conducting a systematic review and meta-analysis, and also to provide a reference for the application of TTNS in OAB.

Methods

A systematic review of eligible articles will be conducted using Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. A comprehensive search of the literature will be conducted in PubMed, Web of Science, The Cochrane Library, Chinese National Knowledge Infrastructure Database (CNKI), Wanfang Data, Weipu Electronics, and other databases. We will include randomized controlled trials about TTNS in females with OAB in MS. Two reviewers will screen titles, abstracts, and full texts independently. We will use a hierarchy of recommended assessment, development, and assessment methods to assess the overall certainty of the evidence and report findings accordingly. Endnote X9 will be used to select the studies and Review Manager V.5.4 (Cochrane Collaboration) will be used to conduct the meta-analysis. The mean difference or standard deviation with 95% confidence interval (CI) will be used in the computation of continuous variables to synthesize data.

Results

The results will provide evidence for judging whether TTNS is effective in females with OAB and MS.

Conclusion

This study will provide reliable evidence for the effect of TTNS in female patients with OAB and MS.

Trial registration

Systematic review registration: PROSPERO CRD42021256861.
Stoic attitude in patients with cancer from the NEOcoping study: Cross-sectional study
Authors: Gomez David , Carmona-Bayonas Alberto , Hernandez Raquel , Higuera Oliver , Rogado Jacobo , Pacheco-Barcia Vilma , Valero María , Gil-Raga Mireia , Mar Muñoz Mª , Carrión-Galindo Rafael , Jimenez-Fonseca Paula , Calderon Caterina
Published: July 2022

Aim

Stoicism has been applied to describe a wide range of behaviors in the face of disease and influences an individual’s use of coping strategies. This study tested the relationship between stoicism and social support, optimism, psychological distress, and coping strategies in patients with cancer.

Method

NEOcoping is a multicenter, cross-sectional study. Participants’ data were collected using a standardized, self-report form and LSS, MSPSS, Mini-MAC, BSI-18, and LOT-R questionnaires. Linear regression analyses were used to assess the association between stoicism and distress scores in both genders. A total of 932 individuals with non-metastatic, resected cancer were recruited.

Results

Males perceived a higher risk of recurrence and toxicity with adjuvant chemotherapy and obtained higher stoic attitude scores than females. Women scored higher on somatization, depression, and anxiety. Patients with high stoicism scores were older and experienced more maladaptive coping (helplessness, anxious preoccupation), and depression, while those with lower stoicism scores had greater perceived social support, optimism, and positive attitude. In both males and females, stoicism correlated negatively with perceived social support, optimism, and positive attitude, and positively with helplessness, anxious preoccupation, and depression. In men, stoicism was directly and negatively associated with social support and optimism, and positively with anxious preoccupation. In women, stoicism was positively associated. In women, stoicism was directly and negatively associated with social support and positively with age and optimism. Stoicism was directly and positively associated with helplessness.

Discussion

A stoic attitude was associated with lower social support, reduced optimism, and passive coping strategies (helplessness and anxious preoccupation) in this series of patients with cancer.
Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function
Authors: Dominguez Matthew J. , McCord Jon J. , Sutton R. Bryan
Published: July 2022

Ferlins are complex, multi-domain proteins, involved in membrane trafficking, membrane repair, and exocytosis. The large size of ferlin proteins and the lack of consensus regarding domain boundaries have slowed progress in understanding molecular-level details of ferlin protein structure and function. However, in silico protein folding techniques have significantly enhanced our understanding of the complex ferlin family domain structure. We used RoseTTAFold to assemble full-length models for the six human ferlin proteins (dysferlin, myoferlin, otoferlin, Fer1L4, Fer1L5, and Fer1L6). Our full-length ferlin models were used to obtain objective domain boundaries, and these boundaries were supported by AlphaFold2 predictions. Despite the differences in amino acid sequence between the ferlin proteins, the domain ranges and distinct subdomains in the ferlin domains are remarkably consistent. Further, the RoseTTAFold/AlphaFold2 in silico boundary predictions allowed us to describe and characterize a previously unknown C2 domain, ubiquitous in all human ferlins, which we refer to as C2-FerA. At present, the ferlin domain-domain interactions implied by the full-length in silico models are predicted to have a low accuracy; however, the use of RoseTTAFold and AlphaFold2 as a domain finder has proven to be a powerful research tool for understanding ferlin structure.
Preliminary development of a multidimensional positive youth development scale for young rural and urban adolescents in China
Authors: Wen Ming , Ye Zhi , Lin Danhua , Wang Weidong
Published: July 2022

This study examined the dimensionality, reliability, and validity of a Chinese version of the 5-C Model of positive youth development (PYD), originally developed in the U.S., with a sample of rural and urban young adolescents in China. The Cs represent five youth strengths: competence, confidence, character, caring, and connection. The results of the exploratory factor analyses showed a reasonable data fit with the 5-C Model. The total and subscale scores evinced good internal reliability (α = .7 to .9) and the confirmatory factor analyses confirmed the convergence of the five Cs on a second-order latent factor of PYD, showing adequate goodness of fit (CFI = 0.94; TLI = 0.93; RMSEA = 0.04). Metric and scalar invariance were found across gender. Metric and partial scalar invariance were found for rural-urban groups. Supportive evidence on convergent and discriminatory validity was also found. We conclude that the Chinese version of the 5-C PYD Scale is a reliable and valid instrument, with good construct validity for Chinese young adolescents.
Optimum stratum boundaries and sample sizes for Covid-19 data in Egypt
Authors: Abo_El.Hassan Fatma S. , Hamed Ramadan , Ismail Elham A. , Ezzat Safia M.
Published: July 2022

Stratified random sampling is an effective sampling technique for estimating the population characteristics. The determination of strata boundaries and the allocation of sample size to the strata are two of the most critical factors in maximizing the precision of the estimates. Most surveys are conducted in an environment of severe budget constraints and a specific time is required to finish the survey. So cost and time are two important objectives that are taken under consideration in most surveys. The study suggested Mathematical goal programming model for determining optimum stratum boundaries for an exponential study variable under multiple objectives model when cost and time are under consideration. Compared to other techniques, Goal programming has many advantages in resources planning. Determining the required resources to satisfy the desired goals and the effectiveness of the available resources as well as providing best solutions under different amounts of resources are examples of the advantages of Goal programming. In addition the paper used data on Covid-19 to evaluate the performance of the suggested model for the exponential distribution. The study divided the number of new cases diseases into small, medium and high numbers. It also compared the results with the findings in the reports of the World Health Organization. The suggested mathematical goal programming revealed that Egypt was exposed to three waves of infection during the interval (5/3/2020 to 12/8/2021). These results are identical to the actual reality of covid-19 waves in Egypt.
‘Relationships on campus are situationships’: A grounded theory study of sexual relationships at a Ugandan university
Authors: Choudhry Vikas , Petterson Karen Odberg , Emmelin Maria , Muchunguzi Charles , Agardh Anette
Published: July 2022

Understanding the complexities of sexual relationships is essential to understand the risky sexual behaviours among young people in Ugandan universities. Nine focus group discussions conducted with 31 males and 33 female students in 2014 utilising the grounded theory approach explored the role of sexual relationships in their lives. ‘Relationships in campus are situationships’ emerged as the core category and referred to the variety of sexual interactions within relationships among young people in a Ugandan university. The study findings indicated that sexual interactions often follow a sexual script that undergoes transitions to negotiate various situations. The sexual scripts in these situationships were strongly influenced by local socio-cultural norms and global aspirations among young people. Students often discussed these sexual scripts within a wider discourse on transactional sexual relationships. The motivations for transactional sexual relationships ranged from ‘fulfilling aspirations’ of various kinds on the one hand to ‘being forced into trading sex’ to overcome socio-economic vulnerabilities. Sexual relationships were facilitated by the perception of a university as a sexualized space in which one may enjoy a period of emerging adulthood characterized by exploration in relationships, access to alcohol and prolonged delay in assuming the traditional adult roles of marriage and family. The sexual scripts at the cultural level were grounded in traditional gender roles although at the same time, were under transition during university life with the growing influence of globalization and consumerism in the Ugandan society. Young men and young women must be engaged to critically challenge the implicit assumptions about sexual interactions within various situations that may put them at risk for poor sexual health outcomes.
Genetic variations in UCA1, a lncRNA functioning as a miRNA sponge, determine endometriosis development and the potential associated infertility via regulating lipogenesis
Authors: Chang Cherry Yin-Yi , Yang Li , Tse Joe , Lo Lun-Chien , Tseng Chung-Chen , Sun Li , Lai Ming-Tsung , Chen Ping-Ho , Hwang Tritium , Chen Chih-Mei , Tsai Fuu-Jen , Sheu Jim Jinn-Chyuan
Published: July 2022

Endometriosis is a hormone-associated disease which has been considered as the precursor for certain types of ovarian cancer. In recent years, emerging evidence demonstrated potent roles of lncRNA in regulating cancer development. Since endometriosis shares several features with cancer, we investigated the possible involvement of cancer-related lncRNAs in endometriosis, including UCA1, GAS5 and PTENP1. By using massARRAY system, we investigated certain genetic variations in cancer-related lncRNAs that can change the thermo-stability, leading to up-regulation or down-regulation of those lncRNAs. Our data indicated three risk genetic haplotypes in UCA1 which can stabilize the RNA structure and increase the susceptibility of endometriosis. Of note, such alterations were found to be associated with long-term pain and infertility in patients. It has been known that UCA1 can function as a ceRNA to sponge and inhibit miRNAs, resulting in loss-of-control on downstream target genes. Gene network analyses revealed fatty acid metabolism and mitochondria beta-oxidation as the major pathways associated with altered UCA1 expression in endometriosis patients. Our study thus provides evidence to highlight functional/epigenetic roles of UCA1 in endometriosis development via regulating fatty acid metabolism in women.
Development, characterization and In-vitro evaluation of guar gum based new polymeric matrices for controlled delivery using metformin HCl as model drug
Authors: Ashames Akram , Ullah Kaleem , Al-Tabakha Moawia , Khan Shujaat Ali , Hassan Nageeb , Mannan Abdul , Ikram Muhammad , Buabeid Manal , Murtaza Ghulam
Published: July 2022

Currently, hydrogels are considered as ideal biomaterials due to their unique structure and characteristics that facilitates considerable hydrophilicity, swelling, drug loading and release. In this study, we report pH-responsive GG-MAA-AMPS hydrogel delivery system prepared via free radical polymerization technique. Hydrogels were loaded with Metformin HCl as a model drug. Hydrogels were characterized through Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and scanning electron microscopy (SEM). FTIR confirmed the successful crosslinking of reactants, hydrogel network formation and drug loading. TGA and DSC proved the higher thermal stability of reactants after crosslinking and drug loading. XRD analysis showed decrease in crystallinity of drug after loading into the hydrogels. SEM revealed smooth and glassy appearance of both loaded and unloaded hydrogels. Gel content was increased with increase in concentration of reactants. Drug entrapment was decreased by increasing concentration of GG and AMPS while MAA acted inversely. Hydrogels displayed pH-dependent swelling and drug release behavior being high at pH 6.8 and 7.4 while low at acidic pH (1.2). Oral tolerability in rabbits showed that hydrogels were safe without causing any hematological or histopathological changes in healthy rabbits. Based on the obtained results, GG-MAA-AMPS can be considered as potential carrier for metformin HCl as well as other hydrophilic drugs.
Zinc transport from the endoplasmic reticulum to the cytoplasm via Zip7 is necessary for barrier dysfunction mediated by inflammatory signaling in RPE cells
Authors: Xu YongYao , Twarog Michael , Li Ning , Banks Angela , Schustak Josh , Bao Yi , Huang Qian , Medley Quintus G.
Published: July 2022

Inflammatory signaling induces barrier dysfunction in retinal-pigmented epithelium (RPE) cells and plays a role in the pathology of age-related macular degeneration (AMD). We studied the role of Zn flux from the endoplasmic reticulum (ER) to the cytoplasm via Zip7 during inflammatory signaling in RPE cells. In ARPE-19 cells, Zip7 inhibition reduced impedance loss, FITC-dextran permeability and cytokine induction caused by challenge with IL-1β/TNF-α. Zip7 inhibition in iPS-derived RPE cells challenged with TNF- α reduced barrier loss in TER assays. In ARPE-19 cells, a Zn ionophore restored cytokine induction and barrier loss in cells challenged with IL-1 β /TNF- α despite Zip7 inhibition. A cell permeable Zn chelator demonstrated that Zn is essential for IL-1 β /TNF- α signaling. ER stress caused by Zip7 inhibition in ARPE-19 cells was found to partially contribute to reducing barrier dysfunction caused by IL-1 β /TNF- α. Overall, it was shown that Zn flux through Zip7 from the ER to the cytoplasm plays a critical role in driving barrier dysfunction caused by inflammatory cytokines in RPE cells.
An evolutionary machine learning algorithm for cardiovascular disease risk prediction
Authors: Ordikhani Mohammad , Saniee Abadeh Mohammad , Prugger Christof , Hassannejad Razieh , Mohammadifard Noushin , Sarrafzadegan Nizal
Published: July 2022

Introduction

This study developed a novel risk assessment model to predict the occurrence of cardiovascular disease (CVD) events. It uses a Genetic Algorithm (GA) to develop an easy-to-use model with high accuracy, calibrated based on the Isfahan Cohort Study (ICS) database.

Methods

The ICS was a population-based prospective cohort study of 6,504 healthy Iranian adults aged ≥ 35 years followed for incident CVD over ten years, from 2001 to 2010. To develop a risk score, the problem of predicting CVD was solved using a well-designed GA, and finally, the results were compared with classic machine learning (ML) and statistical methods.

Results

A number of risk scores such as the WHO, and PARS models were utilized as the baseline for comparison due to their similar chart-based models. The Framingham and PROCAM models were also applied to the dataset, with the area under a Receiver Operating Characteristic curve (AUROC) equal to 0.633 and 0.683, respectively. However, the more complex Deep Learning model using a three-layered Convolutional Neural Network (CNN) performed best among the ML models, with an AUROC of 0.74, and the GA-based eXplanaible Persian Atherosclerotic CVD Risk Stratification (XPARS) showed higher performance compared to the statistical methods. XPARS with eight features showed an AUROC of 0.76, and the XPARS with four features, showed an AUROC of 0.72.

Conclusion

A risk model that is extracted using GA substantially improves the prediction of CVD compared to conventional methods. It is clear, interpretable and can be a suitable replacement for conventional statistical methods.