bluuebunny/crossref_metadata_2025 huggingface dataset:
Structural Characterization of Perpendicularly Aligned Submicrometer-Thick Synthetic Glycolipid Polycrystalline Films Using Conventional X-ray Diffraction
Authors: Ogawa Shigesaburo , Takahashi Isao
Published: December 2017

The structural analysis of the synthetic glycolipid crystalline phase has been performed during the past few decades; however, it has not been sufficiently understood in terms of both static and dynamic aspects. We have recently shown that grazing incidence X-ray diffraction (GIXD) affords better information than conventional powder X-ray diffraction (PXRD) for the crystal structure analysis of octyl β-d-galactoside (MOβGal) using sub-micrometer-thick crystalline films and a two-dimensional detector, together with a synchrotron radiation source. However, access to this technique is not universal because of the limited machine time at the required synchrotron radiation sources. Herein, we employed XRD analysis on MOβGal hemihydrate crystalline films using commercial X-ray sources instead of synchrotron radiation sources to extend the availability of the methodology. We investigated some technical aspects of the methodology, such as incident angle and radiation time, using MOβGal polycrystalline films with different thicknesses in order to obtain sufficient reciprocal data for identifying the lattice constants with conventional X-ray sources. Complementary uses of GIXD with a two-dimensional detector, with much higher incident angles than the total reflection angle using a NANO-Viewer system and out-of-plane and in-plane measurements using SmartLab, enabled us to determine the complete lattice parameters for the MOβGal hemihydrate crystalline film.
Harnessing Genetic Diversity of Wild Gene Pools to Enhance Wheat Crop Production and Sustainability: Challenges and Opportunities
Authors: Ceoloni Carla , Kuzmanović Ljiljana , Ruggeri Roberto , Rossini Francesco , Forte Paola , Cuccurullo Alessia , Bitti Alessandra
Published: December 2017

Wild species are extremely rich resources of useful genes not available in the cultivated gene pool. For species providing staple food to mankind, such as the cultivated Triticum species, including hexaploid bread wheat (Triticum aestivum, 6x) and tetraploid durum wheat (T. durum, 4x), widening the genetic base is a priority and primary target to cope with the many challenges that the crop has to face. These include recent climate changes, as well as actual and projected demographic growth, contrasting with reduction of arable land and water reserves. All of these environmental and societal modifications pose major constraints to the required production increase in the wheat crop. A sustainable approach to address this task implies resorting to non-conventional breeding strategies, such as “chromosome engineering”. This is based on cytogenetic methodologies, which ultimately allow for the incorporation into wheat chromosomes of targeted, and ideally small, chromosomal segments from the genome of wild relatives, containing the gene(s) of interest. Chromosome engineering has been successfully applied to introduce into wheat genes/QTL for resistance to biotic and abiotic stresses, quality attributes, and even yield-related traits. In recent years, a substantial upsurge in effective alien gene exploitation for wheat improvement has come from modern technologies, including use of molecular markers, molecular cytogenetic techniques, and sequencing, which have greatly expanded our knowledge and ability to finely manipulate wheat and alien genomes. Examples will be provided of various types of stable introgressions, including pyramiding of different alien genes/QTL, into the background of bread and durum wheat genotypes, representing valuable materials for both species to respond to the needed novelty in current and future breeding programs. Challenging contexts, such as that inherent to the 4x nature of durum wheat when compared to 6x bread wheat, or created by presence of alien genes affecting segregation of wheat-alien recombinant chromosomes, will also be illustrated.
Assessment of Heart Rate Variability during an Endurance Mountain Trail Race by Multi-Scale Entropy Analysis
Authors: Vallverdú Montserrat , Ruiz-Muñoz Aroa , Roca Emma , Caminal Pere , Rodríguez Ferran A. , Irurtia Alfredo , Perera Alexandre
Published: December 2017

The aim of the study was to analyze heart rate variability (HRV) response to high-intensity exercise during a 35-km mountain trail race and to ascertain whether fitness level could influence autonomic nervous system (ANS) modulation. Time-domain, frequency-domain, and multi-scale entropy (MSE) indexes were calculated for eleven mountain-trail runners who completed the race. Many changes were observed, mostly related to exercise load and fatigue. These changes were characterized by increased mean values and standard deviations of the normal-to-normal intervals associated with sympathetic activity, and by decreased differences between successive intervals related to parasympathetic activity. Normalized low frequency (LF) power suggested that ANS modulation varied greatly during the race and between individuals. Normalized high frequency (HF) power, associated with parasympathetic activity, varied considerably over the race, and tended to decrease at the final stages, whereas changes in the LF/HF ratio corresponded to intervals with varying exercise load. MSE indexes, related to system complexity, indicated the existence of many interactions between the heart and its neurological control mechanism. The time-domain, frequency-domain, and MSE indexes were also able to discriminate faster from slower runners, mainly in the more difficult and in the final stages of the race. These findings suggest the use of HRV analysis to study cardiac function mechanisms in endurance sports.
Diurnal Thermal Behavior of Photovoltaic Panel with Phase Change Materials under Different Weather Conditions
Authors: Lim Jae-Han , Lee Yoon-Sun , Seong Yoon-Bok
Published: December 2017

The electric power generation efficiency of photovoltaic (PV) panels depends on the solar irradiation flux and the operating temperature of the solar cell. To increase the power generation efficiency of a PV system, this study evaluated the feasibility of phase change materials (PCMs) to reduce the temperature rise of solar cells operating under the climate in Seoul, Korea. For this purpose, two PCMs with different phase change characteristics were prepared and the phase change temperatures and thermal conductivities were compared. The diurnal thermal behavior of PV panels with PCMs under the Seoul climate was evaluated using a 2-D transient thermal analysis program. This paper discusses the heat flow characteristics though the PV cell with PCMs and the effects of the PCM types and macro-packed PCM (MPPCM) methods on the operating temperatures under different weather conditions. Selection of the PCM type was more important than the MMPCM methods when PCMs were used to enhance the performance of PV panels and the mean operating temperature of PV cell and total heat flux from the surface could be reduced by increasing the heat transfer rate through the honeycomb grid steel container for PCMs. Considering the mean operating temperature reduction of 4 °C by PCM in this study, an efficiency improvement of approximately 2% can be estimated under the weather conditions of Seoul.
Study on Flow in Fractured Porous Media Using Pore-Fracture Network Modeling
Authors: Liu Haijiao , Zhang Xuhui , Lu Xiaobing , Liu Qingjie
Published: December 2017

Microscopic flow in fractured porous media is a typical problem for the exploitation of tight reservoirs. The rapid-flow in the fractured porous-media is of great significance to efficient and continuous oil/gas exploitation. The fractures are expected to enhance flow conductivity and mass transfer between matrix and fractures, and to improve oil displacement during water flooding. However, the fractures may also lead to water channeling under some conditions. The understanding on the mechanism of the microscopic flow in the fractured porous media has been insufficient until now. In this paper, a two-dimensional pore-fracture network model is presented to study the role of fractures in the flow. The effects of two main dimensionless parameters, fracture length to network length lf/l and fracture density Nf/N, on the absolute permeability and the oil displacement efficiency are investigated. The results show that the flow in the matrix plays a controlling role at a low fracture density. Once the fracture density exceeds a certain value, the flow is controlled by fractures. With the increase of the fracture density, the oil displacement efficiency develops into three typical stages: when Nf/N < 0.1, the oil displacement efficiency increases rapidly; when 0.1 < Nf/N < 0.5, the oil displacement efficiency changes slowly; and when Nf/N > 0.5, the oil displacement efficiency decreases rapidly. In the case lf/l > 0.8, the water mainly flows through a concentrated path connected by some fractures, resulting in it bypassing most oil regions, and thus the oil displacement efficiency decreases rapidly, similar to the water channeling.
Studies on an Electromagnetic Transient Model of Offshore Wind Turbines and Lightning Transient Overvoltage Considering Lightning Channel Wave Impedance
Authors: Zhang Li , Fang Shengwei , Wang Guozheng , Zhao Tong , Zou Liang
Published: December 2017

In recent years, with the rapid development of offshore wind turbines (WTs), the problem of lightning strikes has become more and more prominent. In order to reduce the failure rate caused by the transient overvoltage of lightning struck offshore WTs, the influencing factors and the response rules of transient overvoltage are analyzed. In this paper, a new integrated electromagnetic transient model of offshore WTs is established by using the numerical calculation method of the electromagnetic field first. Then, based on the lightning model and considering the impedance of the lightning channel, the transient overvoltage of lightning is analyzed. Last, the electromagnetic transient model of offshore WTs is simulated and analyzed by using the alternative transients program electro-magnetic transient program (ATP-EMTP) software. The influence factors of lightning transient overvoltage are studied. The main influencing factors include the sea depth, the blade length, the tower height, the lightning flow parameters, the lightning strike point, and the blade rotation position. The simulation results show that the influencing factors mentioned above have different effects on the lightning transient overvoltage. The results of the study have some guiding significance for the design of the lightning protection of the engine room.
Assessment of Energy Performance and Emission Control Using Alternative Fuels in Cement Industry through a Process Model
Authors: Rahman Azad , Rasul Mohammad , Khan M.M.K. , Sharma Subhash
Published: December 2017

Cement manufacturing is one of the most energy intensive processes and is accountable for substantial pollutant emissions. Increasing energy costs compel stakeholders and researchers to search for alternative options to improve energy performance and reduce CO2 emissions. Alternative fuels offer a realistic solution towards the reduction of the usage of fossil fuels and the mitigation of pollutant emissions. This paper developed a process model of a precalciner kiln system in the cement industry using Aspen Plus software to simulate the effect of five alternative fuels on pollutant emissions and energy performance. The alternatives fuels used were tyre, municipal solid waste (MSW), meat and bone meal (MBM), plastic waste and sugarcane bagasse. The model was developed on the basis of energy and mass balance of the system and was validated against data from a reference cement plant. This study also investigated the effect of these alternative fuels on the quality of the clinker. The results indicated that up to a 4.4% reduction in CO2 emissions and up to a 6.4% reduction in thermal energy requirement could be achieved using these alternative fuels with 20% mix in coal. It was also found that the alternative fuels had minimum influence on the clinker quality except in the case of MSW. Overall, MBM was found to be a better option as it is capable on reducing energy requirement and CO2 emissions more than others. The outcomes of the study offer better understanding of the effects of solid alternative fuels to achieve higher energy performance and on mitigating pollutant emissions in cement industry.
Performance Evaluation of a Desiccant Dehumidifier with a Heat Recovery Unit
Authors: Yang Kai-Shing , Wang Jian-Sin , Wu Shih-Kuo , Tseng Chih-Yung , Shyu Jin-Cherng
Published: December 2017

In order to effectively increase the drying rate and reduce the energy consumption, a dryer which reduces the air humidity at the dryer inlet using desiccant and regenerates the desiccant by recovering waste heat using a heat pipe heat exchanger was developed in this study. Both the adsorption rate and desorption rate of the dryer were measured at several ambient temperatures ranging from 15 °C to 35 °C, relative humidity levels of air ranging from 20% to 85%, and airflow rates ranging from 30 m3/h to 150 m3/h. The results showed that the adsorption rate in an environment of high relative humidity of air was 4.89 times higher than that of low relative humidity of air at 15 °C. Moreover, the difference in adsorption rate between two given relative humidity of air increased as the ambient temperature decreased. The specific energy consumption estimated with both energy consumption during desorption and the desorption rate indicated that the energy consumption was 8.27 kJ/g H2O without using recovered heat, while the energy consumption was 4.77 kJ/g H2O using recovered heat at 130 °C.
Lithium Ion Battery Models and Parameter Identification Techniques
Authors: Barcellona Simone , Piegari Luigi
Published: December 2017

Nowadays, battery storage systems are very important in both stationary and mobile applications. In particular, lithium ion batteries are a good and promising solution because of their high power and energy densities. The modeling of these devices is very crucial to correctly predict their state of charge (SoC) and state of health (SoH). The literature shows that numerous battery models and parameters estimation techniques have been developed and proposed. Moreover, surveys on their electric, thermal, and aging modeling are also reported. This paper presents a more complete overview of the different proposed battery models and estimation techniques. In particular, a method for classifying the proposed models based on their approaches is proposed. For this classification, the models are divided in three categories: mathematical models, physical models, and circuit models.
Solution Validation for a Double Façade Prototype
Authors: Fonseca i Casas Pau , Fonseca i Casas Antoni , Garrido-Soriano Nuria , Godoy Alfonso , Pujols Wendys-Carolina , Garcia Jesus
Published: December 2017

A Solution Validation involves comparing the data obtained from the system that are implemented following the model recommendations, as well as the model results. This paper presents a Solution Validation that has been performed with the aim of certifying that a set of computer-optimized designs, for a double façade, are consistent with reality. To validate the results obtained through simulation models, based on dynamic thermal calculation and using Computational Fluid Dynamic techniques, a comparison with the data obtained by monitoring a real implemented prototype has been carried out. The new validated model can be used to describe the system thermal behavior in different climatic zones without having to build a new prototype. The good performance of the proposed double façade solution is confirmed since the validation assures there is a considerable energy saving, preserving and even improving interior comfort. This work shows all the processes in the Solution Validation depicting some of the problems we faced and represents an example of this kind of validation that often is not considered in a simulation project.
Comparison of Model-Based Control Solutions for Severe Riser-Induced Slugs
Authors: Pedersen Simon , Jahanshahi Esmaeil , Yang Zhenyu , Skogestad Sigurd
Published: December 2017

Control solutions for eliminating severe riser-induced slugs in offshore oil & gas pipeline installations are key topics in offshore Exploration and Production (E&P) processes. This study describes the identification, analysis and control of a low-dimensional control-oriented model of a lab-scaled slug testing facility. The model is analyzed and used for anti-slug control development for both lowpoint and topside transmitter solutions. For the controlled variables’ comparison it is concluded that the topside pressure transmitter ( P t ) is the most difficult output to apply directly for anti-slug control due to the inverse response. However, as P t often is the only accessible measurement on offshore platforms this study focuses on the controller development for both P t and the lowpoint pressure transmitter ( P b ). All the control solutions are based on linear control schemes and the performance of the controllers are evaluated from simulations with both the non-linear MATLAB and OLGA models. Furthermore, the controllers are studied with input disturbances and parametric variations to evaluate their robustness. For both pressure transmitters the H ∞ loop-shaping controller gives the best performance as it is relatively robust to disturbances and has a fast convergence rate. However, P t does not increase the closed-loop bifurcation point significantly and is also sensitive to disturbances. Thus the study concludes that the best option for single-input-single-output (SISO) systems is to control P b with a H ∞ loop-shaping controller. It is suggested that for cases where only topside transmitters are available a cascaded combination of the outlet mass flow and P t could be considered to improve the performance.
The Tripartite Game Model for Electricity Pricing in Consideration of the Power Quality
Authors: Zang Tianlei , Xiang Yueping , Yang Jianwei
Published: December 2017

Under the Energy Internet concept the distribution and management of resources in the electricity market have been gradually transiting from a centralized pattern to a decentralized pattern. Correspondingly, the methodological model for the analysis of economic behaviors needs to be upgraded too. Based on the idea of non-cooperative game theory, this paper puts forward a tripartite game model for electricity pricing in consideration of the power quality, which is applicable to the electricity market under the Energy Internet with distributed generation, including the State Grid Corporation of China (SGCC), generating companies (GENCOs) and the marketers which correspond to the regional power-retailing companies. Then, the sequential quadratic programming based on the quasi-Newton method is given to solve the game model. Finally, four sets of tests with different game factors are carried out to verify the validity and feasibility of the proposed model and algorithm. The SGCC price, the cost and the number of GENCOs and the cross-regional environment are considered in each test, respectively. The results show that this model can adapt well to the various conditions.
Switch-Like Roles for Polycomb Proteins from Neurodevelopment to Neurodegeneration
Authors: Hoffmann Anke , Sportelli Vincenza , Ziller Michael , Spengler Dietmar
Published: December 2017

Polycomb Group (PcG) proteins are best-known for maintaining repressive or active chromatin states that are passed on across multiple cell divisions, and thus sustain long-term memory of gene expression. PcG proteins engage different, partly gene- and/or stage-specific, mechanisms to mediate spatiotemporal gene expression during central nervous system development. In the course of this, PcG proteins bind to various cis-regulatory sequences (e.g., promoters, enhancers or silencers) and coordinate, as well the interactions between distantly separated genomic regions to control chromatin function at different scales ranging from compaction of the linear chromatin to the formation of topological hubs. Recent findings show that PcG proteins are involved in switch-like changes in gene expression states of selected neural genes during the transition from multipotent to differentiating cells, and then to mature neurons. Beyond neurodevelopment, PcG proteins sustain mature neuronal function and viability, and prevent progressive neurodegeneration in mice. In support of this view, neuropathological findings from human neurodegenerative diseases point to altered PcG functions. Overall, improved insight into the multiplicity of PcG functions may advance our understanding of human neurodegenerative diseases and ultimately pave the way to new therapies.
Hierarchical Control of Nitrite Respiration by Transcription Factors Encoded within Mobile Gene Clusters of Thermus thermophilus
Authors: Alvarez Laura , Quintáns Nieves G. , Blesa Alba , Baquedano Ignacio , Mencía Mario , Bricio Carlos , Berenguer José
Published: December 2017

Denitrification in Thermus thermophilus is encoded by the nitrate respiration conjugative element (NCE) and nitrite and nitric oxide respiration (nic) gene clusters. A tight coordination of each cluster’s expression is required to maximize anaerobic growth, and to avoid toxicity by intermediates, especially nitric oxides (NO). Here, we study the control of the nitrite reductases (Nir) and NO reductases (Nor) upon horizontal acquisition of the NCE and nic clusters by a formerly aerobic host. Expression of the nic promoters PnirS, PnirJ, and PnorC, depends on the oxygen sensor DnrS and on the DnrT protein, both NCE-encoded. NsrR, a nic-encoded transcription factor with an iron–sulfur cluster, is also involved in Nir and Nor control. Deletion of nsrR decreased PnorC and PnirJ transcription, and activated PnirS under denitrification conditions, exhibiting a dual regulatory role never described before for members of the NsrR family. On the basis of these results, a regulatory hierarchy is proposed, in which under anoxia, there is a pre-activation of the nic promoters by DnrS and DnrT, and then NsrR leads to Nor induction and Nir repression, likely as a second stage of regulation that would require NO detection, thus avoiding accumulation of toxic levels of NO. The whole system appears to work in remarkable coordination to function only when the relevant nitrogen species are present inside the cell.
Geospatial Analysis of Land Use and Land Cover Transitions from 1986–2014 in a Peri-Urban Ghana
Authors: Appiah Divine , Forkuo Eric , Bugri John , Apreku Theresa
Published: December 2017

Recently, peri-urbanisation has led to the transformation of the rural landscape, changing rural land uses into peri-urban land uses, under varying driving factors. This paper analyzes the dynamic transitions among identified land use and land cover (LULC) types in the Bosomtwe district of Ghana, from 1986 to 2014. An integrated approach of geo-information tools of satellite remote sensing in Earth Resource Data Analysis System (ERDAS) Imagine 13 and ArcMap 10.2 Geographic Information System (GIS), with Markov chain analytical techniques were used to examine the combined forest land cover transitions, relative to build-up, recent fallows and grasslands and projected possible factors influencing the transitions under business as usual and unusual situations. Statistical analyses of the classified Landsat TM, ETM+ and Landsat 8 Operational Land Imager and Thermal Infrared Sensor (OLI/TIS) indicated that over the period of 24 years, the Bosomtwe district has undergone a series of land use conversions with remarkable forest losses especially between 2002 and 2010. In 2010 dense forest cover was degraded to low forest by 4040 ha indicating 0.40% transition probability in the future. There was a remarkable increase of built-up/bare and concrete area with a 380% increment in the 1986–2002 transition periods. The application of the Markov futuristic land use dynamics by the years 2018 and 2028, projected from the 2014 LULC indicated a future steady decline in the area coverage of the dense forest to low forest category. This is currently being driven (as at the 2017 LULC trends), by the combined effects of increasing build up bare and concrete surface land uses as well as the expanding recent fallows and grassland. The paper concluded that the health of the ecosystem and biodiversity of the lake Bosomtwe need to be sustainably managed by the Bosomtwe district assembly.
Automated Ecological Assessment of Physical Activity: Advancing Direct Observation
Authors: Carlson Jordan , Liu Bo , Sallis James , Kerr Jacqueline , Hipp J. , Staggs Vincent , Papa Amy , Dean Kelsey , Vasconcelos Nuno
Published: December 2017

Technological advances provide opportunities for automating direct observations of physical activity, which allow for continuous monitoring and feedback. This pilot study evaluated the initial validity of computer vision algorithms for ecological assessment of physical activity. The sample comprised 6630 seconds per camera (three cameras in total) of video capturing up to nine participants engaged in sitting, standing, walking, and jogging in an open outdoor space while wearing accelerometers. Computer vision algorithms were developed to assess the number and proportion of people in sedentary, light, moderate, and vigorous activity, and group-based metabolic equivalents of tasks (MET)-minutes. Means and standard deviations (SD) of bias/difference values, and intraclass correlation coefficients (ICC) assessed the criterion validity compared to accelerometry separately for each camera. The number and proportion of participants sedentary and in moderate-to-vigorous physical activity (MVPA) had small biases (within 20% of the criterion mean) and the ICCs were excellent (0.82–0.98). Total MET-minutes were slightly underestimated by 9.3–17.1% and the ICCs were good (0.68–0.79). The standard deviations of the bias estimates were moderate-to-large relative to the means. The computer vision algorithms appeared to have acceptable sample-level validity (i.e., across a sample of time intervals) and are promising for automated ecological assessment of activity in open outdoor settings, but further development and testing is needed before such tools can be used in a diverse range of settings.
Quantitative Properties of the Macro Supply and Demand Structure for Care Facilities for Elderly in Japan
Authors: Nishino Tatsuya
Published: December 2017

As the Asian country with the most aged population, Japan, has been modifying its social welfare system. In 2000, the Japanese social care vision turned towards meeting the elderly’s care needs in their own homes with proper formal care services. This study aims to understand the quantitative properties of the macro supply and demand structure for facilities for the elderly who require support or long-term care throughout Japan and present them as index values. Additionally, this study compares the targets for establishing long-term care facilities set by Japan’s Ministry of Health, Labor and Welfare for 2025. In 2014, approximately 90% of all the people who were certified as requiring support and long-term care and those receiving preventive long-term care or long-term care services, were 75 years or older. The target increases in the number of established facilities by 2025 (for the 75-years-or-older population) were calculated to be 3.3% for nursing homes; 2.71% for long-term-care health facilities; 1.7% for group living facilities; and, 1.84% for community-based multi-care facilities. It was revealed that the establishment targets for 2025 also increase over current projections with the expected increase of the absolute number of users of group living facilities and community-based multi-care facilities. On the other hand, the establishment target for nursing homes remains almost the same as the current projection, whereas that for long-term-care health facilities decreases. These changes of facility ratios reveal that the Japanese social care system is shifting to realize ‘Ageing in Place’. When considering households’ tendencies, the target ratios for established facilities are expected to be applied to the other countries in Asia.
Hazard Ranking Method for Populations Exposed to Arsenic in Private Water Supplies: Relation to Bedrock Geology
Authors: Crabbe Helen , Fletcher Tony , Close Rebecca , Watts Michael , Ander E. , Smedley Pauline , Verlander Neville , Gregory Martin , Middleton Daniel , Polya David , Studden Mike , Leonardi Giovanni
Published: December 2017

Approximately one million people in the UK are served by private water supplies (PWS) where main municipal water supply system connection is not practical or where PWS is the preferred option. Chronic exposure to contaminants in PWS may have adverse effects on health. South West England is an area with elevated arsenic concentrations in groundwater and over 9000 domestic dwellings here are supplied by PWS. There remains uncertainty as to the extent of the population exposed to arsenic (As), and the factors predicting such exposure. We describe a hazard assessment model based on simplified geology with the potential to predict exposure to As in PWS. Households with a recorded PWS in Cornwall were recruited to take part in a water sampling programme from 2011 to 2013. Bedrock geologies were aggregated and classified into nine Simplified Bedrock Geological Categories (SBGC), plus a cross-cutting “mineralized” area. PWS were sampled by random selection within SBGCs and some 508 households volunteered for the study. Transformations of the data were explored to estimate the distribution of As concentrations for PWS by SBGC. Using the distribution per SBGC, we predict the proportion of dwellings that would be affected by high concentrations and rank the geologies according to hazard. Within most SBGCs, As concentrations were found to have log-normal distributions. Across these areas, the proportion of dwellings predicted to have drinking water over the prescribed concentration value (PCV) for As ranged from 0% to 20%. From these results, a pilot predictive model was developed calculating the proportion of PWS above the PCV for As and hazard ranking supports local decision making and prioritization. With further development and testing, this can help local authorities predict the number of dwellings that might fail the PCV for As, based on bedrock geology. The model presented here for Cornwall could be applied in areas with similar geologies. Application of the method requires independent validation and further groundwater-derived PWS sampling on other geological formations.
Research and Development of a DNDC Online Model for Farmland Carbon Sequestration and GHG Emissions Mitigation in China
Authors: Jiang Zaidi , Yin Shan , Zhang Xianxian , Li Changsheng , Shen Guangrong , Zhou Pei , Liu Chunjiang
Published: December 2017

Appropriate agricultural practices for carbon sequestration and emission mitigation have a significant influence on global climate change. However, various agricultural practices on farmland carbon sequestration usually have a major impact on greenhouse gas (GHG) emissions. It is very important to accurately quantify the effect of agricultural practices. This study developed a platform—the Denitrification Decomposition (DNDC) online model—for simulating and evaluating the agricultural carbon sequestration and emission mitigation based on the scientific process of the DNDC model, which is widely used in the simulation of soil carbon and nitrogen dynamics. After testing the adaptability of the platform on two sampling fields, it turned out that the simulated values matched the measured values well for crop yields and GHG emissions. We used the platform to estimate the effect of three carbon sequestration practices in a sampling field: nitrogen fertilization reduction, straw residue and midseason drainage. The results indicated the following: (1) moderate decrement of the nitrogen fertilization in the sampling field was able to decrease the N2O emission while maintaining the paddy rice yield; (2) ground straw residue had almost no influence on paddy rice yield, but the CH4 emission and the surface SOC concentration increased along with the quantity of the straw residue; (3) compared to continuous flooding, midseason drainage would not decrease the paddy rice yield and could lead to a drop in CH4 emission. Thus, this study established the DNDC online model, which is able to serve as a reference and support for the study and evaluation of the effects of agricultural practices on agricultural carbon sequestration and GHG emissions mitigation in China.
A Cluster Randomized Trial to Promote Healthy Menu Items for Children: The Kids’ Choice Restaurant Program
Authors: Ayala Guadalupe X. , Castro Iana A. , Pickrel Julie L. , Lin Shih-Fan , Williams Christine B. , Madanat Hala , Jun Hee-Jin , Zive Michelle
Published: December 2017

Evidence indicates that restaurant-based interventions have the potential to promote healthier purchasing and improve the nutrients consumed. This study adds to this body of research by reporting the results of a trial focused on promoting the sale of healthy child menu items in independently owned restaurants. Eight pair-matched restaurants that met the eligibility criteria were randomized to a menu-only versus a menu-plus intervention condition. Both of the conditions implemented new healthy child menu items and received support for implementation for eight weeks. The menu-plus condition also conducted a marketing campaign involving employee trainings and promotional materials. Process evaluation data captured intervention implementation. Sales of new and existing child menu items were tracked for 16 weeks. Results indicated that the interventions were implemented with moderate to high fidelity depending on the component. Sales of new healthy child menu items occurred immediately, but decreased during the post-intervention period in both conditions. Sales of existing child menu items demonstrated a time by condition effect with restaurants in the menu-plus condition observing significant decreases and menu-only restaurants observing significant increases in sales of existing child menu items. Additional efforts are needed to inform sustainable methods for improving access to healthy foods and beverages in restaurants.
Thyroid Disrupting Chemicals
Authors: Calsolaro Valeria , Pasqualetti Giuseppe , Niccolai Filippo , Caraccio Nadia , Monzani Fabio
Published: December 2017

Endocrine disruptor compounds are exogenous agents able to interfere with a gland function, exerting their action across different functional passages, from the synthesis to the metabolism and binding to receptors of the hormone produced. Several issues, such as different levels and time of exposure and different action across different ages as well as gender, make the study of endocrine disruptors still a challenge. The thyroid is very sensitive to the action of disruptors, and considering the importance of a correct thyroid function for physical and cognitive functioning, addressing this topic should be considered a priority. In this review, we examined the most recent studies, many of them concentrating on maternal and child exposure, conducted to assess the impact of industrial chemicals which showed an influence on thyroid function. So far, the number of studies conducted on that topic is not sufficient to provide solid conclusions and lead to homogeneous guidelines. The lack of uniformity is certainly due to differences in areas and populations examined, the different conditions of exposures and the remarkable inter-subject variability. Nonetheless, the European Commission for Health and Food Safety is implementing recommendations to ensure that substances identified as endocrine disruptors will be withdrawn from the market.
Alternative Oral Agents in Prophylaxis and Therapy of Uterine Fibroids—An Up-to-Date Review
Authors: Ciebiera Michał , Łukaszuk Krzysztof , Męczekalski Błażej , Ciebiera Magdalena , Wojtyła Cezary , Słabuszewska-Jóźwiak Aneta , Jakiel Grzegorz
Published: December 2017

Uterine fibroids (UFs) are the most common tumors of the female genital tract. The effect of UFs on the quality of life and the overall cost of treatment are significant issues worldwide. Tumor size and location are the two specific factors which influence the occurrence of symptoms, the need for, and method of, treatment (some tumors require surgery while some can be treated with selected drugs). Primary prevention and treatment of early UF disease are worthy goals that might have a great impact on health care systems. Several treatments and prophylactic methods can be used in this endeavor. This publication presents current data about lesser-known substances which may have a beneficial effect on the treatment or prophylaxis of UFs and can be administered orally, serving as an alternative to (or complement of) surgery or selective progesterone receptor modulators (SPRMs). Early prevention and treatment of UFs in women from high-risk groups should be our priority. Innovative forms of UF management are under intensive investigation and may be promising options in the near future. Many of them evaluated vitamin D, paricalcitol, epigallocatechin gallate (EGCG), elagolix, aromatase inhibitors (AIs), and cabergoline and deemed them to be safe and effective. The next step in such projects should be properly constructed randomized control trials (RCTs), carried out by successive phases.
Aquaporins during Pregnancy: Their Function and Significance
Authors: Ducza Eszter , Csányi Adrienn , Gáspár Róbert
Published: December 2017

Water is the major component of cells and tissues, and the movement of water across the cell membrane is a fundamental property of life. Until the discovery of the first water channel, aquaporin, it was long assumed that the transport of water was due to simple diffusion through the lipid bilayer membrane that encloses cells. Aquaporin (AQP) molecules were first discovered in the human uterus in 1994, and since then several studies have investigated these channels in the female reproductive system. The expressions of AQPs have been proven in the reproductive system. Their levels are altered during the implantation process, both in the uterus and the fetal cells, and participate in the control of the flow of amniotic fluid. They seem to be very important for the normal placental functions. AQPs are present during parturition, participating in the control of pregnant myometrial contractions and cervical ripening. However, most of the physiological and regulatory roles of AQPs are not clarified in the reproductive tract. Furthermore, no satisfactory knowledge is available about their sensitivities to different drugs. AQP-selective ligands may contribute to the development of new drug candidates and the therapy of several reproductive disorders.
Morphology Changes in Human Fungal Pathogens upon Interaction with the Host
Authors: Li Zhongming , Nielsen Kirsten
Published: December 2017

Morphological changes are a very common and effective strategy for pathogens to survive in the mammalian host. During interactions with their host, human pathogenic fungi undergo an array of morphological changes that are tightly associated with virulence. Candida albicans switches between yeast cells and hyphae during infection. Thermally dimorphic pathogens, such as Histoplasma capsulatum and Blastomyces species transform from hyphal growth to yeast cells in response to host stimuli. Coccidioides and Pneumocystis species produce spherules and cysts, respectively, which allow for the production of offspring in a protected environment. Finally, Cryptococcus species suppress hyphal growth and instead produce an array of yeast cells—from large polyploid titan cells to micro cells. While the morphology changes produced by human fungal pathogens are diverse, they all allow for the pathogens to evade, manipulate, and overcome host immune defenses to cause disease. In this review, we summarize the morphology changes in human fungal pathogens—focusing on morphological features, stimuli, and mechanisms of formation in the host.
Comparative Studies on Ultraviolet-Light-Derived Photoresponse Properties of ZnO, AZO, and GZO Transparent Semiconductor Thin Films
Authors: Tsay Chien-Yie , Hsu Wei-Tse
Published: December 2017

ZnO, Al-doped ZnO (AZO), and Ga-doped ZnO (GZO) semiconductor thin films were deposited on glass substrates via a sol-gel spin-coating process for application in a photoconductive ultraviolet (UV) detector. The doping concentrations of Al and Ga were 1.0 at % in the precursor solutions. In this study, the microstructural features and the optical and electrical properties of sol-gel-derived ZnO, AZO, and GZO thin films were compared, and the performance of ZnO-based UV photodetectors under ultraviolet A (UVA) light were measured. Experimental results confirmed the synthesis of single-phase nanocrystalline ZnO-based thin films and the successful substitution of Al and Ga into Zn sites in ZnO crystals. The results also demonstrated that the optical transmittance and electrical properties of ZnO thin films could be improved by Al and Ga doping. UV photodetectors based on ZnO-based thin films, having a metal-semiconductor-metal (MSM) configuration, were fabricated with Al inter-digitated electrodes. All photodetectors showed an ohmic nature between semiconductor and electrode contacts and exhibited a sharp increase in photocurrent under illumination with UVA light. We found that the MSM UV photodetector based on the GZO semiconductor thin film exhibited the best UV response (IUVA/Idark) of 73.3 and the highest photocurrent responsivity of 46.2 A/W under UVA light (power density ~0.825 mW/cm2) at 5 V bias.
The Marine Fungi Rhodotorula sp. (Strain CNYC4007) as a Potential Feed Source for Fish Larvae Nutrition
Authors: Barra M. , Llanos-Rivera A. , Cruzat F. , Pino-Maureira N. , González-Saldía R.
Published: December 2017

Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like “El Niño” are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study assesses a strain of Rhodotorula sp. (strain CNYC4007; 27% docosahexaenoic acid (DHA) of total fatty acids), as feed for fish larvae. The total length and ribonucleic acid (RNA)/deoxyribonucleic acid (DNA) ratio of Danio rerio larvae was determined at first feeding at six and 12 days old (post-yolk absorption larvae). Larvae fed with microencapsulated Rhodotorula sp. CNYC4007 had a significantly higher RNA/DNA ratio than control group (C1). At six days post-yolk absorption group, the RNA/DNA ratio of larvae fed with Rhodotorula sp. bioencapsulated in Brachionus sp. was significantly higher than control group fed with a commercial diet high in DHA (C2-DHA). Finally, at 12 days post-yolk absorption, the RNA/DNA ratio was significantly higher in larvae fed with Rhodotorula sp. CNYC4007 and C2-DHA (both bioencapsulated in Artemia sp. nauplii) than in control group (C1). These results suggest that Rhodotorula sp. CNYC4007 can be an alternative source of DHA for feeding fish at larval stage, providing a sustainable source of fatty acids.
The Effect of Two-Step Heat Treatment Parameters on Microstructure and Mechanical Properties of 42SiMn Steel
Authors: Kučerová Ludmila
Published: December 2017

Medium-carbon steel 42SiMn (0.4C-0.6Mn-2Si-0.03Nb) was used for a two-step heat treatment consisting of a soaking hold and an annealing hold at bainite transformation temperature. Various heating temperatures, cooling rates, and bainitic hold temperatures were applied to the steel to obtain microstructures typical for TRIP (Transformation Induced Plasticity) steels. TRIP steels utilize the positive effects of a multiphase microstructure with retained austenite, creating a good combination of strength and total elongation and an excellent deep-drawing ability. Typical microstructures consist of ferrite, bainite, and 10–15% of retained austenite. In this work, tensile strengths in the region of 887–1063 MPa were achieved with total elongation A5mm of 26–47%, and the final microstructures contained 4–16% of retained austenite. The most suitable microstructure and the best combination of high strength and total elongation were achieved for the processing with intercritical heating temperature of 850 °C and cooling at 30 °C/s to the bainitic hold of 400 °C. Very fine pearlite persisted in the microstructures, even after applying a cooling rate of 50 °C/s, however these small areas with extremely fine laths did not prevent the retention of up to 16% of retained austenite, and high total elongation A5mm above 40% was still reached for these microstructures.
Controlled Synthesis of Monodisperse Hexagonal NaYF4:Yb/Er Nanocrystals with Ultrasmall Size and Enhanced Upconversion Luminescence
Authors: Li Hui , Xu Lei , Chen Guanying
Published: December 2017

The ability to synthesize upconversion nanocrystals (UCNCs) with tailored upconversion luminescence and controlled size is of great importance for biophotonic applications. However, until now, limited success has been met to prepare bright, ultrasmall, and monodispersed β-NaYF4:Yb3+/Er3+ UCNCs. In this work, we report on a synthetic method to produce monodisperse hexagonal NaYF4:Yb3+/Er3+ nanocrystals of ultrasmall size (5.4 nm) through a precise control of the reaction temperature and the ratio of Na+/Ln3+/F−. We determined the optimum activator concentration of Er3+ to be 6.5 mol % for these UCNCs, yielding about a 5-fold higher upconversion luminescence (UCL) intensity than the commonly used formula of NaYF4:30% Yb3+/2% Er3+. Moreover, a thin epitaxial shell (thickness, 1.9 nm) of NaLnF4 (Ln = Y, Gd, Lu) was grown onto these ultrasmall NaYF4:Yb3+/Er3+ NCs, enhancing its UCL by about 85-, 70- and 50-fold, respectively. The achieved sub-10-nm core and core–shell hexagonal NaYF4:Yb3+/Er3+ UCNCs with enhanced UCL have strong potential applications in bioapplications such as bioimaging and biosensing.
Anti-Proliferative Activity of Triterpenoids and Sterols Isolated from Alstonia scholaris against Non-Small-Cell Lung Carcinoma Cells
Authors: Wang Chao-Min , Tsai Shang-Jie , Jhan Yun-Lian , Yeh Kuei-Lin , Chou Chang-Hung
Published: December 2017

(1) Background: In China and South Asia, Alstonia scholaris (Apocynaceae) is an important medicinal plant that has been historically used in traditional ethnopharmacy to treat infectious diseases. Although various pharmacological activities have been reported, the anti-lung cancer components of A. scholaris have not yet been identified. The objective of this study is to evaluate the active components of the leaf extract of A. scholaris, and assess the anti-proliferation effects of isolated compounds against non-small-cell lung carcinoma cells; (2) Methods: NMR was used to identify the chemical constitutes isolated from the leaf extract of A. scholaris. The anti-proliferative activity of compounds against non-small-cell lung carcinoma cells was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; (3) Results: Eight triterpenoids and five sterols were isolated from the hexane portion of A. scholaris, and structurally identified as: (1) ursolic acid, (2) oleanolic acid, (3) betulinic acid, (4) betulin, (5) 2β,3β,28-lup-20(29)-ene-triol, (6) lupeol, (7) β-amyrin, (8) α-amyrin, (9) poriferasterol, (10) epicampesterol, (11) β-sitosterol, (12) 6β-hydroxy-4-stigmasten-3-one, and (13) ergosta-7,22-diene-3β,5α,6β-triol. Compound 5 was isolated from a plant source for the first time. In addition, compounds 9, 10, 12, and 13 were also isolated from A. scholaris for the first time. Ursolic acid, betulinic acid, betulin, and 2β,3β,28-lup-20(29)-ene-triol showed anti-proliferative activity against NSCLC, with IC50 of 39.8, 40.1, 240.5 and 172.6 μM, respectively.; (4) Conclusion: These findings reflect that pentacyclic triterpenoids are the anti-lung cancer chemicals in A. scholaris. The ability of ursolic acid, betulinic acid, betulin, and 2β,3β,28-lup-20(29)-ene-triol to inhibit the proliferative activity of NSCLC can constitute a valuable group of therapeutic agents in the future.