bluuebunny/crossref_metadata_2025 huggingface dataset:
A “Burlesque Queen in Bobby Socks”: Domesticity, Criminality, and Suspense in Charles Williams’s Noir Fiction
Authors: Jaber Maysaa Husam
Published: November 2021

This article proposes that Charles Williams’s mid-twentieth-century noir fiction reshapes post-war representations of gender roles and paves the way for various renditions and developments of noir. Williams’s works are narratives of transgression meeting domesticity, crime meeting docility, and cunning meeting conformity; they portray a deadly recipe that comprises different, even conflicting ingredients of a fusion between domesticity, crime, and suspense. By examining the recurring figure of the criminal housewife in his work, especially Hell Hath No Fury (1953), this article argues that Williams brings forth a complex and subversive gender schema to trouble both the creed of domesticity popular in the 1950s and the stereotyping of the lethal seductress prevalent in noir fiction. By so doing, Williams’s noir not only brings the transgression of women to the fore but also displays a compelling picture of post-war gender roles in the US under McCarthyism.
Jurisdiction of the Original Church Organization in Kiev: Historical Hypotheses and Canonical Opportunity
Authors: Задорнов Александр
Published: November 2021

В первой трети XX века русскими историками неоднократно выдвигались гипотезы о неподчинении первоначальной киевской церковной организации Константинопольскому патриархату (М. Приселков, А. Карташев, Г. Вернадский). Впоследствии эти гипотезы были маргинализированы ввиду отсутствия достоверных исторических сведений о таком епархиальном устройстве, однако в последние десятилетия появились новые литургико-канонические основания для возвращения к этой научной гипотезе на новом уровне. В настоящей статье рассматриваются такие основания и их важность для изучения первоначальной древнерусской церковной организации.

In the first third of the 20th century historians repeatedly made hypotheses of non-obedience of the ancient Kiev's Church organization to the Constantinople patriarchy (M. Priselkov, A. Kartashev, G. Vernadsky). At the last decades the new canonical and liturgical bases for return to this scientific hypothesis at the new level have appeared. In the article such bases and their value for this historical hypothesis are considered. Overview of the features of the canonical status of Church structures in the Kievan Rus' the turn of the two millennia allows in the future to clarify the thesis in Canon law on the ratio of territorial, national and public administration principles in the formation of the Church in its history.
The History of the Divine Service to All Russian Saints
Authors: Супрун Сергей Валентинович
Published: November 2021

В данной статье автор рассматривает историю службы Всем русским святым с момента её возникновения до настоящего времени. Созданная в середине XVI века насельником Суздальского Спасо-Евфимиева монастыря иноком Григорием, служба пережила долгие годы забвения, которые пришлись на Синодальный период истории Русской Церкви. Она возродилась на Поместном Соборе 1917-1918 годов благодаря стараниям профессора Петроградского университета Бориса Александровича Тураева. На протяжении многих лет служба совершенствовалась и дополнялась святителем Афанасием (Сахаровым) и другими русскими гимнографами. Впервые возрождённая служба Всем русским святым была опубликована к моменту закрытия Поместного Собора в 1918 году. Следующее её издание с «политическими» правками вышло в 1946 году после окончания Великой Отечественной войны. В 1987 году, к 1000-летию Крещения Руси, в майской Минее был напечатан текст данной службы, который использовался за богослужением до 2015 года, после чего постановлением Священного Синода был в очередной раз отредактирован. Служба Всем святым, в земле Русской просиявшим, несомненно является самым замечательным произведением русской гимнографии XX века, и ознакомление с её историей позволит читателю лучше понять смысл не только данного последования, но и самого праздника Всех Русских святых.

In this article the author considers the history of the divine service to All Russian Saints since its beginning until present time. The divine service, created in the middle of the 16 century by Grigoriy, a monk of Suzdal the Saviour Monastery of Saint Euthymius, had been in oblivion for many years, during the Synodal period of the Russian Church history and was reborn at the 1917-1918 Church Council due to efforts of Boris Aleksandrovich Turaev. Since the Council it has been improved and complemented by St Afanasiy (Sakharov) and other hymnographers for many years. In 1918 the close of the Church Council saw the first publication of the text of the divine service to All Russian Saints. Its next «politically» edited option was published in 1946 after the Great Patriotic war. In 1987, in commemoration of the 1000th anniversary of Russian Baptism, the text was published in May Mineya. The text had been used for worship until 2015. Later it was once again edited by the decision of the Holy Synod.The divine service to All the Saints, whose light shone forth in Russian land, is undoubtedly the most remarkable work of Russian hymnography of the 20th century. The acquaintance with its history allows the reader to understand the sense of not only this service order, but also the Feast itself.
Edition of Russian Translation of Pidalion St. Nicodemus the Hagioriteand Its Features
Authors: Пашков Димитрий
Published: November 2021

В статье прослеживается история работы над русским переводом одного из самых важных памятников церковного права - «Пидалиона» преподобного Никодима Святогорца. Отмечены особенности предпринятого сестрами Ново-Тихвинского Екатеринбургского монастыря издания, отмечена важность издания для развития науки канонического права в России.

In article the history of work on Russian translation of one of the most important monuments of canon law - Pidalion of the st. Nicodemus the Hagiorite. Features of the New Tikhvin Ekaterinburg monastery of the edition undertaken by sisters are noted, importance of the edition for development of science of the canon law in Russia is noted
Meritocracy and its Enemies: Is There an Alternative to the “Tyranny of the Merit”?
Authors: Davydov Dmitriy
Published: November 2021

The article examines  the idea of meritocracy, now increasingly criticized. It is shown that the relevance of the discourse on meritocracy is due to the objectively increased role of education and various creative and technical talents in the context of rapid technological development. At the same time, critics rightly point out that meritocracy today has become largely a myth that plutocrats turn to justify their privileges, status and wealth. The very idea of a meritocracy that focuses exclusively on the technical competencies and abilities demanded by the neoliberal economy is also criticized. Many authors talk about the need to fairly reward and respect low-skilled workers, who often (especially in the context of the COVID-19 pandemic) bring more public benefit than highly educated financiers or bankers. Nevertheless, the article shows that this criticism is a hidden apology for meritocracy. In this case, critics justify deeper inequalities associated with long-term prospects and self-realization. It leads to cementing the “secondary” status of workers of the “hand” and “heart”, whose fate in the context of automation and the development of artificial intelligence technologies may turn out to be unenviable. In the author's opinion, the only alternative to this state of affairs is the rejection of meritocracy as a normative concept. It should be recognized as an inevitable evil associated with the imperfection of social institutions and, in part, human nature. Accordingly, the author contrasts the meritocratic pursuit of status and power with the ideal of universal striving for the maximum possible and, what is remarkable, all-round development and practical application of the talents of all without exception.
The Impact of the District’s Magnitude on the Gender Composition of the Municipal Deputy Corps
Authors: Mukhametov Ruslan S.
Published: November 2021

The purpose of the study is to explain the difference in the proportion of women deputies in the representative bodies of different municipalities. The author assesses the impact of the electoral districts size on the gender composition of municipal legislative bodies (dumas). A review of theoretical and empirical works shows that more women are elected to Parliament under the proportional representation system than under the majority system with single-mandate constituencies. According to the author, the decisive factor is not the type of the electoral system, but the size of the electoral district. Two working hypotheses were formulated. According to the first, representative bodies of municipalities, whose elections are held according to a majority system with multi-member districts, will have a higher representation of women than local dumas which are formed on the basis of a majority system with single-member districts. According to the second hypothesis, higher representation of women in the deputy corps of settlements can be associated with the holding of elections under the majority system with multi-mandate districts. To test the proposed hypotheses in the context of municipalities, empirical material was collected. The study was carried out on the data from the Sverdlovsk region. The database of indicators of municipalities of Rosstat, as well as the official websites of local administrations were used as the source of information. The method of multiple linear regression is used as the main research method. The data was analyzed with the Gretl applied statistical program. Statistical calculations have revealed a positive and statistically significant impact of multi-mandate constituencies-based elections on the proportion of women in the deputy corps, which contributes to the study of gender aspects of politics. It is shown that the size of the electoral district is important for the representation of women in the city councils. The article notes that the transition to holding elections of deputies on the basis of a majority system with multi-mandate districts will help increase the proportion of women in municipal representative bodies.
VALIDATION OF A SHORT VERSION OF THE SCALE OF SATISFACTION WITH THE WORK ENVIRONMENT (ÉSET-24)
Authors:   Université Paris Nanterre, Moffat Eva
Published: November 2021

The scale of satisfaction with the work environment (ÉSET-24) is a shortened version of the French scale of satisfaction with the work environment (Moffat, Mogenet & Rioux, 2016). Participants were 580 employees in various professional sectors. Confirmatory factor analysis showed eight latent factors with a second-order general latent factor structure. The implications for human resource management are discussed
OVERVIEW OF THE RELATIONS BETWEEN THE EUROPEAN UNION AND THE STATE OF ISRAEL
Authors:   The Theodor Herzl Centre for Israeli Studies, National University of Political Studies and Public Administration, Axinte T. N. , Bolborici Ana Maria ,   Transilvania University of Braşov
Published: November 2021

The objective of this paper work is to try to formulate an analysis identifying whether there is an influence on the part of the European Union in the Middle East, specifically in Israel. If we take into account the region in which the state of Israel is located, we will realize that this is a state affected by various conflicts. The State of Israel is an associate member of the European Union and due to the economically strong relations that the European Union has had with Israel over time, we can ask ourselves in which way can the European Community influence this country in other areas as well.
THE IMPACT OF EMOTIONAL INTELLIGENCE ON ORGANIZATIONAL CLIMATE
Authors:   Transilvania University of Brașov, Tantaru Oana , Mesesan Schmitz Luiza ,   Transilvania University of Brașov, Moasa Horia ,   Transilvania University of Brașov
Published: November 2021

This paper highlights the relationship between employees` emotional intelligence and their experience of organizational climate. We analyze the two concepts in two Romanian multinational organizations and we demonstrate that emotional intelligence has a positive impact on organizational climate, which means that employees with higher scores of emotional intelligence experience a more positive organizational climate. Also, a higher level of heterogeneity in EQ scores leads to a more negative perception of organizational climate.
Complications with moderate-to-severe COVID-19 during hospital admissions in patients with pneumonia
Authors: ŞAHİN ÖZDEMİREL Tuğçe , AKKURT Esma Sevil , ERTAN Özlem , GÖKLER Mehmet Enes , AKINCI ÖZYÜREK Berna
Published: November 2021

Introduction: Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is an infectious disease that has caused significant mortality and morbidity worldwide. COVID-19 is known to cause complications, such as myocardial damage, acute coronary syndrome, deep vein thrombosis, pulmonary embolism, arrhythmia, heart failure, acute ischemic stroke, liver damage, cytokine storms, ischemia-reperfusion damage and side effects of drug treatments. In our study, we aimed to evaluate the complications that developed during hospitalizations in patients with moderate-to-severe COVID-19 related pneumonia who were hospitalized in our COVID-19 service.

Material and Method: This study included patients with moderate-to-severe COVID-19 pneumonia with a positive reverse transcriptase polymerase chain reaction (RT-PCR) test who were treated in our COVID-19 service between November 2020 and January 2021. Their demographic characteristics, treatment regimens, baseline laboratory values and complications during their hospitalization were retrospectively recorded.

Results: The study group had a mean age of 62.92± 14.60 years and 40.6% (n= 55) were female. Approximately 35.3% (n= 48) of the patients developed complications due to COVID-19 during their follow-up period. Of the patients with complications, 63.8% (n: 30) were male, most common complications were elevated liver enzymes (47.9%) and pulmonary thromboembolism (20.8%). Of those patients with complications, the most common comorbidities were hypertension (40.4% [n= 19]), diabetes mellitus (25.5% [n=12]) and cardiovascular disease (23.4% [n=11]). There were no significant relationships between the presence of complications and age, sex or comorbid diseases (p>0.05 for each).

Conclusion: There are more underlying conditions, such as hypertension, diabetes mellitus, cardiovascular disease, chronic lung disease in hospitalized patients with moderate-to-severe pneumonia compared to outpatients with COVID-19 pneumonia. Complications develop, especially in the management of COVID-19 pneumonia, which affect the treatment process and patient mobilization.
Aortic arch calcification is strongly associated with obstructive sleep apnea
Authors: ZORLU Çağrı
Published: November 2021

Aim: Obstructive sleep apnea (OSA) is a common clinical condition that causes an increase in cardiovascular morbidity and mortality. OSA is likely to show increased arterial stiffness and progressive systemic atherosclerosis. Chest radiography reveals atherosclerotic changes in the aorta.The aim of this study was to investigate the relationship between aortic arch calcification (AAC) on chest radiography and OSA.

Material and Method: 204 patients (age: 55±14 years; 78 men) who were diagnosed with OSA by performing night polysomnography were evaluated. On the other hand 200 (age: 48±15 years; 94 men) patients were selected to the group non OSA. AAC was evaluated with chest radiography and inter-observer agreement was analyzed by using kappa statistics. Univariate and multivariate logistic regression analysis was conducted to assess the association of AAC and OSA. P-value
Neutrophil-to-lymphocyte ratio in patients with white-coat hypertension
Authors: AVŞAR Esin , TAZEGÜL Gökhan , ÇOBAN Erkan
Published: November 2021

Introduction: White coat hypertension (WCH), a distinct phenotype of hypertension, is defined as elevated office blood pressure (BP) measurements during repeat visits with normal out-of-office BP measurements. The association of WCH with cardiovascular risk remains unclear; however, current data support an association between untreated WCH and the risk for cardiovascular events, cardiovascular mortality, and all-cause mortality. Increased inflammatory processes may explain the underlying pathophysiology of the increased risk for cardiovascular events in WCH; therefore, we evaluated the neutrophil-to-lymphocyte ratio (NLR) of patients with WCH compared with matched normotensive controls.

Material and Method: Forty-five eligible subjects with WCH and 45 age, sex, and BMI matched healthy and normotensive subjects were included in the study. The subjects were assessed by office arterial BP and 24-hour ambulatory BP measurements. An automated blood count analyzer measured the NLR values.

Results: The mean NLR in the patients-with-WCH group was significantly higher than that in the control group (2.67±0.27 vs. 2.46±0.34, p
Pain catastrophizing in migraine patients and associated factors
Authors: HARMANCI Hatice , KUL Birsel
Published: November 2021

Aim: We carried out this study to examine the level of pain catastrophizing (PC) among migraine patients and factors possibly affecting PC.

Material and Method: The sample of this study comprised 120 patients who applied to the neurology clinic of a state hospital and were diagnosed with migraine by the International Headache Society’s (IHS) criteria between April 2017 – March 2019. Then, we collected the data from those meeting the inclusion criteria using a socio-demographic information form, the Pain Catastrophizing Scale (PCS), and the Barrat Impulsiveness Scale Short Form (BIS-11-SF). Data analysis was performed on the SPSS 25.0 statistics software. To explore the relationships between the variables, we ran one-way ANOVA and multiple regression analyses and calculated Pearson’s correlation coefficients.

Results: We divided the participants into three groups: Group 1 included 30 patients who got full benefit from the treatment during a migraine attack (25%); Group 2 included 25 patients who were unable to obtain any benefit from the treatment at all (20.8%); Group 3 included 65 patients with partial benefit from the treatment (54.17%). The PCS scores were higher in Group 1 and Group 3, while Group 2 had significantly higher PCS total and Rumination scores than Group 1. The number of attacks and impulsiveness levels of the patients explained 18.6% of the variance in PC.

Conclusion: The cognitive capacity of individuals is essential in identifying the prognosis of migraine. Catastrophizing pain is likely to lower treatment response in migraine patients. Besides, the increased number of attacks and impulsiveness levels of patients influence their PC levels. Finally, migraine is a disorder with a psychiatric aspect; therefore, performing appropriate mental evaluations and offering necessary psychiatric support may enhance the chance of success in migraine treatment.
A Parametric Study on the HDPE/PP and Marble Slurry Waste Utilisation Using Single Screw Extruder
Authors: Chaudhary Ritu , Upadhyaya Sushant , Sangal Vikas Kumar
Published: November 2021

Due to the increased socio-economic development, the manufacturing of different products based on various polymers for different applications such as space crafts, airplanes, automobiles, boats, and sports equipment are increasing continuously. This huge increase in solid polymer commodities is also creating the extravagant quantity of solid waste polymers (SWPs) due to their non-degradable characteristics. These SWPs, for example, high-density polyethylene (HDPE), polypropylene (PP), low-density polyethylene (LDPE), and nylon, etc., are used frequently in various applications and create new challenges to the industries, government, as well as end-users for systematic waste recycling/recovery in an eco-friendly manner. Moreover, in this modernisation era, almost all marble industries are also facing a huge problem as marble slurry (MS) yields a great burden not only due to its limited degradability characteristics but also wider environmental hazard towards water bodies, and rivers. Fine particles in the range size of 45-300 micron in the MS create air pollution which in turn increases breathing problems. Moreover, it also creates an ecological adverse impact on soil fertility and reduces the percolation rate of rain water which in turn reduces the recharging of groundwater. Therefore, keeping in view the above facts, the simultaneous recycling of HDPE, PP and marble slurry is adopted through single screw extrusion in order to reduce the burden on the environment. Moreover, the effect of various process parameters viz barrel temperature, screw speed (rpm), feed composition, and grain size of PP and HDPE on extrudate output was envisaged. It was found that the extrudate output increases steeply on increasing the average barrel temperature from 100 to 120°C and linearly with screw speed range from 65 to 85 rpm. The effect of grain size had shown decreasing trend in throughput whereas on increasing the polymer content in the feed, throughput was found to be enhanced. Additives such as HPMC were found to be effective when used in synergy with HDPE and PP along with MS. The extrudate throughput was found to be a maximum of 33.01 g/minute at 120°C, 85 screw rpm, 1.40-grain size underfeed with equal proportionate of HDPE/PP with 2% HPMC and 8% MS. This clearly opens the ways for proper utilization of HDPE, PP and MS waste by extrusion and provides the environmental protection solution by utilizing these polluted materials in the fabrication of value-added products through extrusion.
Prediction of Sand Production Through Porous Media: Mechanisms and Challenges to Optimising the Inefficiencies
Authors: Huang Wenhua , Huang Yan , Ren Juan , Jiang Jinglong , Elveny Marischa
Published: November 2021

One of the challenges facing drilling companies in the completion and production of oil and gas wells is sand production from the formation. The ability to predict sand production in the wells of a reservoir, to decide to use different methods of control is considered a fundamental issue. Therefore, analysis and study of sand production conditions and selecting the optimal drilling route before drilling wells are significant issues that are less considered. According to the findings of this study, due to the sand grains adhesion issue, saturation increase has caused to increase in the intermolecular uptake, and therefore moisture has been decreased. It leads to reduction in the sand production rate. Pressure increase has a direct relationship with the sand production rate due to increased induced drag forces. Moreover, phenol–formaldehyde resins provided an acceptable measurement as there are no significant changes in porosity and permeability.
YAMATO: Yet-another more advanced top-level ontology
Authors: Mizoguchi Riichiro , Borgo Stefano
Published: November 2021

yamato sharply distinguishes itself from other existing upper ontologies in the following respects. (1) Most importantly, yamato is designed with both engineering and philosophical minds. (2) yamato is based on a sophisticated theory of roles, given that the world is full of roles. (3) yamato has a tenable theory of functions which helps to deal with artifacts effectively. (4) Information is a ‘content-bearing’ entity and it differs significantly from the entities that philosophers have traditionally discussed. Taking into account the modern society in which a flood of information occurs, yamato has a sophisticated theory of informational objects (representations). (5) Quality and quantity are carefully organized for the sake of greater interoperability of real-world data. (6) The philosophical contribution of yamato includes a theory of objects, processes, and events. Those features are illustrated with several case studies. These features lead to the intensive application of yamato in some domains such as biomedicine and learning engineering.
Mitochondrial Membrane Potential Influences Amyloid-β Protein Precursor Localization and Amyloid-β Secretion
Authors: Wilkins Heather M. , Troutwine Benjamin R. , Menta Blaise W. , Manley Sharon J. , Strope Taylor A. , Lysaker Colton R. , Swerdlow Russell H.
Published: November 2021

Background: Amyloid-β (Aβ), which derives from the amyloid-β protein precursor (AβPP), forms plaques and serves as a fluid biomarker in Alzheimer’s disease (AD). How Aβ forms from AβPP is known, but questions relating to AβPP and Aβ biology remain unanswered. AD patients show mitochondrial dysfunction, and an Aβ/AβPP mitochondria relationship exists. Objective: We considered how mitochondrial biology may impact AβPP and Aβ biology. Methods: SH-SY5Y cells were transfected with AβPP constructs. After treatment with FCCP (uncoupler), Oligomycin (ATP synthase inhibitor), or starvation Aβ levels were measured. β-secretase (BACE1) expression was measured. Mitochondrial localized full-length AβPP was also measured. All parameters listed were measured in ρ0 cells on an SH-SY5Y background. iPSC derived neurons were also used to verify key results. Results: We showed that mitochondrial depolarization routes AβPP to, while hyperpolarization routes AβPP away from, the organelle. Mitochondrial AβPP and cell Aβ secretion inversely correlate, as cells with more mitochondrial AβPP secrete less Aβ, and cells with less mitochondrial AβPP secrete more Aβ. An inverse relationship between secreted/extracellular Aβ and intracellular Aβ was observed. Conclusion: Our findings indicate mitochondrial function alters AβPP localization and suggest enhanced mitochondrial activity promotes Aβ secretion while depressed mitochondrial activity minimizes Aβ secretion. Our data complement other studies that indicate a mitochondrial, AβPP, and Aβ nexus, and could help explain why cerebrospinal fluid Aβ is lower in those with AD. Our data further suggest Aβ secretion could serve as a biomarker of cell or tissue mitochondrial function.
Thrust ripple analysis for improved modular tubular permanent magnet synchronous linear motor
Authors: Wu Qingle , Yang Guolai , Tang Enling , Wang Liqun , Wang Xiuye
Published: November 2021

Various technologies have ever been developed to minimize the detent force of linear motors. Although the traditional modular structure can effectively reduce the detent force, the width of the flux barrier and the number of units severely limit its application. To solve these, this paper proposes a new modular type of tubular permanent magnet synchronous linear motor (TPMSLM), which consists of two identical unit motors. For simplification, a subdomain analytical method of the unit motor is firstly established, and its accuracy is verified by a comparison with that of the finite element method. Using the two approaches, the important parameters of the motor are analyzed. A modified two-unit modular TPMSLM is also proposed through the star vectograms of the electromotive force, which achieves thrust performance similar to the traditional three-unit modular TPMSLM with a smaller axial size. Moreover, to make full use of the volume of the flux barrier, end teeth are added at both ends of the unit motors. The simulation results indicate that a reasonable end tooth structure can not only reduce the magnetic leakage phenomenon of the end but also effectively improve the thrust of the motor.
Iron Chelation by thiocytosine: Investigating electronic and structural features for describing tautomerism and metal chelation processes
Authors: Jafari Rad Azadeh , Abbasi Maryam , Zohrevand Bahareh
Published: November 2021

This work was performed regarding the importance of iron (Fe) chelation for biological systems. This goal was investigated by assistance of a model of thiocytosine (TC) for participating in Fe-chelation processes. First, formations of tautomeric conformations were investigated to explore existence of possible structures of TC. Next, Fe-chelation processes were examined for all four obtained tautomers of TC. The results indicated that thiol tautomers could be seen at higher stability than thio tautomers, in which one of such thiol tautomers yielded the strongest Fe-chelation process to build FeTC3 model. As a consequence, parallel to the results of original TC tautomers, Fe-chelated models were found to be achievable for meaningful chelation processes or sensing the existence of Fe in media. Examining molecular orbital features could help for sensing purposes. The results of this work were obtained by performing density functional theory (DFT) calculations proposing TC compounds suitable for Fe-chelation purposes.
H2O and H2S adsorption by assistance of a heterogeneous carbon-boron-nitrogen nanocage: Computational study
Authors: Liu Xin , Ahmadi Zahra
Published: November 2021

A model of heterogeneous carbon-boron-nitrogen (C-B-N) nanocage was investigated in this work for adsorbing H2O and H2S substances. To achieve this goal, quantum chemical calculations were performed to obtain optimized configurations of substances towards the surface of nanocage. The calculations yielded three possible configurations for relaxing each of substances towards the surface. Formation of acid-base interactions between vacant orbitals of boron atom and full orbitals of each of oxygen and sulfur atoms yielded the strongest complexes of substance-nanocage in comparison with orientation of substances through their hydrogen atoms towards the surface of nanocage. As a consequence, formations of interacting H2O@C-B-N and H2S@C-B-N complexes were achievable, in which mechanism of action showed different strengths for the obtained complexes. Variations of molecular orbital features and corresponding energy gap and Fermi energy for the models before/after adsorption could help for detection of adsorbed substance through a sensor function. And finally, such C-B-N nanocage showed benefit of providing activated surface for efficient adsorption of each of H2O and H2S substance with possibility of differential adsorption regarding the strength of complex formations.
GC-MS analysis of chemical composition, cytotoxicity and antioxidant activities of essential oils of Senecio glaucus under drastic conditions
Authors: Elsharkawy Eman Ramadan
Published: November 2021

This study was designed to analyze essential oils by GC-MS and to evaluate the chemical composition, cytotoxic and antioxidant activity of aerial part of plant Seniso glaucus using two methods hydro distillation and organic solvent extraction. The essential oil was analyzed by GC-MS revealed the presence of 32 compounds most of them are sesquiterpene, the main component of essential oil were, Isolongifolene, 9-one (14.4%) Longiverbenone (13.5%), (+) 4-Carene (8.39 %), O-cymene, 4.64%, and thujone were 3.54%. Cytotoxic activity of essential oil was tested against four carcinoma cell lines (A549, McF7, HepG, and HCT-16) by using (3- (4, 5- dimethyl thiazolyl-2)-2, 5-diphenyltetrazolium bromide) (MTT), the results indicate promising cytotoxic activity at the concentration (100, and50μg/ml) essential oil exhibit high cytotoxic activities against Hepg2 cell lines (83. 33 and 59.14 %) and good cytotoxicity against A549, McF-7 and HCT116 cell lines by (62.1 %, 74.40 %, and 76.60%respectively). The essential oil showed antioxidant activity with IC50 = 69.59±0.24μg/ml, using 2, 2-diphenyl-1- picrylhydrazyl (DPPH) assay the present study concluded the importance of plant Seniso glaucus as a natural antioxidant.
Federated Mining of Interesting Association Rules Over EHRs
Authors: Molina Carlos , Prados-Suarez Belen , Martinez-Sanchez Beatriz
Published: November 2021

Federated learning has a great potential to create solutions working over different sources without data transfer. However current federated methods are not explainable nor auditable. In this paper we propose a Federated data mining method to discover association rules. More accurately, we define what we consider as interesting itemsets and propose an algorithm to obtain them. This approach facilitates the interoperability and reusability, and it is based on the accessibility to data. These properties are quite aligned with the FAIR principles.
FAIRification Efforts of Clinical Researchers: The Current State of Affairs
Authors: Kersloot Martijn G. , van Damme Philip , Abu-Hanna Ameen , Arts Derk L. , Cornet Ronald
Published: November 2021

The FAIR Principles are supported by various initiatives in the biomedical community. However, little is known about the knowledge and efforts of individual clinical researchers regarding data FAIRification. We distributed an online questionnaire to researchers from six Dutch University Medical Centers, as well as researchers using an Electronic Data Capture platform, to gain insight into their understanding of and experience with data FAIRification. 164 researchers completed the questionnaire. 64.0% of them had heard of the FAIR Principles. 62.8% of the researchers spent some or a lot of effort to achieve any aspect of FAIR and 11.0% addressed all aspects. Most researchers were unaware of the Principles’ emphasis on both human- and machine-readability, as their FAIRification efforts were primarily focused on achieving human-readability (93.9%), rather than machine-readability (31.2%). In order to make machine-readable, FAIR data a reality, researchers require proper training, support, and tools to help them understand the importance of data FAIRification and guide them through the FAIRification process.
Fast Healthcare Interoperability Resources (FHIR) in a FAIR Metadata Registry for COVID-19 Research
Authors: Klofenstein Sophie Anne Ines , Vorisek Carina Nina , Shutsko Aliaksandra , Lehne Moritz , Sass Julian , Löbe Matthias , Schmidt Carsten Oliver , Thun Sylvia
Published: November 2021

Adopting international standards within health research communities can elevate data FAIRness and widen analysis possibilities. The purpose of this study was to evaluate the mapping feasibility against HL7® Fast Healthcare Interoperability Resources® (FHIR)® of a generic metadata schema (MDS) created for a central search hub gathering COVID-19 health research (studies, questionnaires, documents = MDS resource types). Mapping results were rated by calculating the percentage of FHIR coverage. Among 86 items to map, total mapping coverage was 94%: 50 (58%) of the items were available as standard resources in FHIR and 31 (36%) could be mapped using extensions. Five items (6%) could not be mapped to FHIR. Analyzing each MDS resource type, there was a total mapping coverage of 93% for studies and 95% for questionnaires and documents, with 61% of the MDS items available as standard resources in FHIR for studies, 57% for questionnaires and 52% for documents. Extensions in studies, questionnaires and documents were used in 32%, 38% and 43% of items, respectively. This work shows that FHIR can be used as a standardized format in registries for clinical, epidemiological and public health research. However, further adjustments to the initial MDS are recommended – and two additional items even needed when implementing FHIR. Developing a MDS based on the FHIR standard could be a future approach to reduce data ambiguity and foster interoperability.
Influence of Healthcare Organization Factors on Cardiovascular Diseases Mortality
Authors: Metsker Oleg , Kopanitsa Georgy
Published: November 2021

One serious pandemic can nullify years of efforts to extend life expectancy and reduce disability. The coronavirus pandemic has been a perturbing factor that has provided an opportunity to assess not only the effectiveness of health systems for cardio-vascular diseases (CVD), but also their sustainability. The goal of our research is to analyze the influence of public health factors on the mortality from circulatory diseases using machine learning methods. We analysed a very large dataset that consisted of the information collected from the national registers in Russia. We included data from 2015 to 2021. It included 340 factors that characterize organization of healthcare in Russia. The resulting area under receiver operating characteristic curve (AUC of ROC) of the Random Forest based regression model was 92% with a testing dataset. The models allow for automated retraining as time passes and epidemiological and other situations change. They also allow additional characteristics of regions and health care organizations to be added to existing training datasets depending on the target. The developed models allow the calculation of the probability of the target for 6–12 months with an error of 8%. Moreover, the models allow to calculate scenarios and the value of the target indicator when other indicators of the region change.
Fast mining method of network heterogeneous fault tolerant data based on K-means clustering
Authors: Huang Haiyang , Shang Zhanlei
Published: November 2021

In the traditional network heterogeneous fault-tolerant data mining process, there are some problems such as low accuracy and slow speed. This paper proposes a fast mining method based on K-means clustering for network heterogeneous fault-tolerant data. The confidence space of heterogeneous fault-tolerant data is determined, and the range of motion of fault-tolerant data is obtained; Singular value decomposition (SVD) method is used to construct the classified data model to obtain the characteristics of heterogeneous fault-tolerant data; The redundant data in fault-tolerant data is deleted by unsupervised feature selection algorithm, and the square sum and Euclidean distance of fault-tolerant data clustering center are determined by K-means algorithm. The discrete data clustering space is constructed, and the objective optimal function of network heterogeneous fault-tolerant data clustering is obtained, Realize fault-tolerant data fast mining. The results show that the mining accuracy of the proposed method can reach 97%.
Effects of iron deposition in the basal ganglia on white matter functions in early and advanced stages of Parkinson’s disease
Authors:   S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation, Buryak A.B. ,   I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation, Trufanov A.G. ,   S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation, Rashidova S.N. ,   I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation, Efimtsev A.Yu. ,   V.A. Almazov National Medical Research Center, St. Petersburg, Russian Federation, Kuznetsova E.V. ,   1S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation, Odinak M.M. ,   1S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation, Litvinenko I.V. ,   S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation
Published: November 2021

Aim: to assess the effect of iron deposition in the basal ganglia on white matter functions at stages 2 and 3 of Parkinson’s disease using susceptibility-weighted imaging (SWI) and diffusion tensor imaging (DTI) MRI. Patients and Methods: ninety-two patients with Parkinson’s disease (42 patients with Hoehn and Yahr stage 2 and 50 patients with Hoehn and Yahr stage 3) were examined. All patients underwent MRI (Magnetom Trio A Tim 3.0T, Siemens, Germany). The parameters of the SWI pulse sequence were as follows: TR (ms): 28, TE (ms): 20, flip angle: 15, slice thickness (mm): 1, voxel size (mm): 0.71875×0.71875, number of slices: 88. In addition, DTI MRI measured fractional anisotropy of brain pathways to assess the functions and integrity of the white matter. Results: our findings demonstrate a strong association between iron deposition in the basal ganglia and brain pathway dysfunctions. These dysfunctions account for many symptoms occurring in early and late Parkinson’s disease. In addition, the study revealed correlations demonstrating the coexistence of iron deposition progression in the extrapyramidal system and the reduction in white matter fractional anisotropy. Conclusions: our findings provide novel data on the pathogenesis of Parkinson’s disease and allow for assessing neuroimaging patterns at various disease stages and explaining clinical phenomena occurring in Parkinson’s disease. KEYWORDS: Parkinson’s disease, iron deposition, susceptibility-weighted imaging (SWI), magnetic resonance imaging, diffusion tensor imaging (DTI). FOR CITATION: Buryak A.B., Trufanov A.G., Rashidova S.N. et al. Effects of iron deposition in the basal ganglia on white matter functions in early and advanced stages of Parkinson’s disease. Russian Medical Inquiry. 2021;5(10):623–629 (in Russ.). DOI: 10.32364/2587- 6821-2021-5-10-623-629.
Modern patient management with low back pain
Authors:   Yaroslavl State Medical University, Yaroslavl, Russian Federation, Pizova N.V.
Published: November 2021

Low back pain (LBP) is one of the most common pathologies of the musculoskeletal system worldwide. The article presents data on the main causes of LBP (mechanical, non-mechanical and visceral), the importance of differential diagnosis concerning possible causal factors, taking into account the presence of so-called red and yellow flags. The article also notes the fact of increased pain in the lower back and neck revealed in a number of studies in the conditions of COVID-19 and lists the main possible causes of this phenomenon. The expediency of an integrated approach to patient management with acute and chronic LBP, given the principles of evidence-based medicine, is substantiated. Drug therapy means are characterized, and data are presented indicating complex drugs’ efficacy, including those based on NSAIDs with a proven analgesic effect (diclofenac) and B vitamins. The importance of maintaining the physical activity of patients with both acute and chronic LBP and the ability of some non-pharmacological pain therapy methods (manual therapy, Kinesio taping, etc.) to reduce pain and fear of movement are noted. KEYWORDS: low back pain, red flags, differential diagnosis, treatment, NSAIDs, B vitamins. FOR CITATION: Pizova N.V. Modern patient management with low back pain. Russian Medical Inquiry. 2021;5(10):659–667 (in Russ.). DOI: 10.32364/2587-6821-2021-5-10-659-667.
Propaedeutics of pelvic pain
Authors:   City Polyclinics No. 8, Moscow, Russian Federation, Izvozchikov S.B. ,   LLC "Megaclinic", Moscow, Russian Federation
Published: November 2021

Pelvic pain (PP) is an important issue. Current definitions of PP do not reflect its topography, thereby providing prerequisites for arbitrary interpreting of the definition. The author describes PP terminology and classifications and suggests his definition of PP and its topographic classification. The author proposes "chronic tension pelvic pain" (a variant of dysfunctional pelvic pain) and gives pathogenic reasons for its clinical use as a nosological unit. This paper addresses the utility of classifying tension pelvic pain as coupled or not coupled with pelvic floor muscle tension. The author’s results illustrate challenging diagnostic screening of the causes of PP in outpatients referred to a neurologist by doctors of various specialties. The author concludes that PP should be considered an interdisciplinary phenomenon. Familiarizing with the causes of PP and pain patterns of various pathological conditions affecting pelvic organs allows for the rapid selection of adequate diagnostic algorithms. KEYWORDS: propaedeutics, differential diagnosis, pelvic pain, chronic tension pelvic pain, dysfunctional pain, nociceptive pain. FOR CITATION: Izvozchikov S.B. Propaedeutics of pelvic pain. Russian Medical Inquiry. 2021;5(10):694–698 (in Russ.). DOI: 10.32364/2587- 6821-2021-5-10-694-698.
Гігієнічні нормативи хімічних речовин в атмосферному повітрі: досягнення минулого та сучасні погляди у майбутнє
Authors:   State Institution ", Chernychenko I.O. ,   O.M. Marzіeiev Institute for Public Health of the NAMSU",   , Kyiv, Lytvychenko O.M. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Kyiv, Babii V.F. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Kyiv, Balenko N.V. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Kyiv, Kondratenko O.Ye. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Kyiv, Hlavachek D.O. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Kyiv
Published: November 2021

Objective: We generalized and assessed the prior chemical pollutants in accordance with the time of their averaging by the data of domestic and foreign regulatory frameworks. Materials and methods: To achieve the goal, we used the bibliographic and analytical methods. We analyzed the databases of Ukraine and the EU countries, the USA and Canada on the current standards for chemical agents and the time of their averaging in accordance with the purpose - prevention of acute and chronic effects. Results and discussion: As a result of the comparison of the data on the regulations and standards for chemical agents in ambient air, we identified the agents that are criterial ones in most countires. For these substances, monitoring methods have been developed and standards have been substantiated and adopted for two averaging periods: twenty-minute and average daily. In most countries, two standards have been also adopted for each agent, but the averaging period is longer there: an average annual and a daily average. Such standards may control and prevent the chronic effect of substances. As a result, the use of the Ukrainian and foreign standards leads to the controversial estimates of the actual air pollution. The average daily standard adopted in Ukraine, on the one hand, is much stricter in comparison with the similar foreign criteria, and on the other hand, it does not correspond to the peculiarities of the formation of ambient air pollution, and is inadequate for the averaging time. Conclusions: 1. Comparative analysis of hygienic standards indicates the needs to harmonize the ambient air quality standards in force in Ukraine with international ones. 2. The existing system of the hygienic standards in Ukraine must be supplemented with the standard for the annual averaging period by transferring the operating average daily concentrations to this rank.
NARASI PERSUASI SOCIAL MEDIA INFLUENCER DALAM MEMBANGUN KONSEP KECANTIKAN DAN KEPERCAYAAN DIRI
Authors: Ligariaty Yosieana Institute , Irwansyah Irwansyah
Published: November 2021

The existence of social media allows the emergence of social media influencers where in turn they have an impact on social media users. This can happen by bringing up new messages or raising issues about a particular subject. One of them is the topic of the concept of beauty and its relation to self-confidence. Moreover, with the existence of social media influencers who carry out information dissemination activities by compiling and creating content related to the concept of beauty and its relation to self-confidence. By using persuasive narratives, social media influencers build different beauty concepts that can even be contrary to concepts that have been developing in society. The purpose of writing this research is focused on providing an understanding to the wider community, about the narratives used by social media influencers in persuading and penetrating new messages to the public, especially with regard to the concept of ideal beauty related to hairstyles. Through the method of qualitative content analysis techniques to observe the messages conveyed by social media influencers, related to a number of important aspects. The use of qualitative content analysis allows the writer to see the content of the message more deeply, through understanding the meaning of the message.