bluuebunny/crossref_metadata_2025 huggingface dataset:
ISLAM DAN NEO-MODERNISME/ POST-MODERNISME: Perspektif Nurcholish Madjid dan Abdurrahman Wahid
Authors: Rohmawati Yuyun
Published: November 2021

The Western has always insulted Islam as an out of date, irrational, dogmatic, mystical, static, undemocratic religion and so on. Despite the fact, Islam is a religion that rahmatan lil ‘alamin, dynamic and democratic. But the Western negative assessment of Islam is very strongly attached to their memory. So it’s quite difficult to change the Western understanding of Islam. Furthermore, Islamic societies who are too fanatical tend to shut down and reject the modern era. That is what make the problem more complex. Therefore, Indonesian Muslim Intellectuals sought to overcome this problem by developing Neo-modernism/ Post-modernism (in the 20th century). This is in accordance with the purpose of this article which is to find out Islamic discourse and Neo-modernism/ Post-modernism in the perspective of Nurcholish Madjid and Abdurrahman Wahid. The Research was conducted using a qualitative approach of the type of library research. The results of this study indicate that according to these two figures Post-modernism can be used as a bridge to develop Islamic thought as a religion that will always exist in all space and time, but Islamic values must remain radiated in the modern era. Thus, as Muslims especially intellectuals must be able to balance religion and general science.
DINAMIKA PEMIKIRAN KLASIFIKASI ILMU DALAM KHAZANAH INTELEKTUAL ISLAM KLASIK
Authors: Abidin Muhammad Zainal
Published: November 2021

The idea of science integration which is an important issue of Muslims today demands attention to the study of science classification. This topic is among the least touched in discussions related to Islam and science. This article is the result of a literature review that raises classical Muslim intellectual thoughts related to the classification of science. During the heyday of Islam, this issue received serious attention from many Muslim intellectuals at that time. The important findings from this paper are that: First, the repertoire of thought in the classification of science in Islam shows the great enthusiasm of Muslim scientists in the development of science whose impact can be felt today. Second, although there are various variations in the classification of science, they still provide respect and space for metaphysical or religious sciences. Third, there are two patterns in the classification of science as stated by Muslim scientists, some are strongly influenced by the Greek tradition, and some are based on Islamic treasures. This division in the present context, this idea is similar to the view of Islamization of science and the view of Islamic scholarship.
MANAJEMEN PENDIDIKAN ISLAM
Authors: B Barsihannor
Published: November 2021

This article examines thoughts of Prof. Dr. Mujamil Qomar, M.Ag. which expressly states that the success of Islamic education in the level of realityexpectations one of which is determined by the management of Islamic education that serves the task of advancing the implementation, implementation or application of Islamic education institutionally. Among Qomar's thoughts on the management of Islamic education that is pithy and deserves an in-depth study is the nature of Islamic education management and its implications, philosophical objects and praxis as well as the dimensions of Islamic education management, the characteristics and characteristics of Islamic education management, the difference between Islamic education management and education management , as well as about the existence and constraints of Islamic education management. Thought Qomar can be explored clearly in three works, namely Manajemen Pendidikan Islam: Strategi Baru Pengelolaan Lembaga Pendidikan Islam (Management of Islamic Education: New Strategy Management of Islamic Education Institutions), Dimensions of Management of Islamic Education, and Strategy of Islamic Education, as well as other works that are not directly related to the discussion of Islamic education management.
PEMANFAATAN BUKU OLEH MAHASISWA SEBAGAI PENUNJANG AKTIVITAS AKADEMIK DI ERA GENERASI MILENIAL
Authors: Prajawinanti Arin
Published: November 2021

Mahasiswa merupakan calon intelektual masa depan generasi bangsa. Mahasiswa harus bisa menjalankan perannya sebagai pencipta perubahan. Mereka membutuhkan sumber informasi untuk menunjang seluruh aktivitas akademiknya. Di era sekarang ini sumber informasi tersedia dalam berbagai bentuk, apalagi didorong dengan adanya ledakan informasi saat ini. Pemilihan sumber informasi yang dilakukan oleh mahasiswadilakukan dengan adanya berbagai pertimbangan rasional dan juga motivasi yang dimiliki oleh mahasiswa untuk mencapai tujuan. Adanya dorongan dari luar seperti dukungan dari dosen atau lingkungan sekitar juga memiliki peran penting dalam mempengaruhi pilihan sumber informasi yang digunakan. Di lingkungan generasi milenial saat ini masih banyak mahasiswa yang memilih memanfaatkan buku untuk menunjang aktivitas akademiknya. Selain buku mahasiswa juga memanfaatkan sumber informasi dari jurnal. Kata Kunci: Pemanfaatan buku, pilihan rasional, motivasi
Perpustakaan digital, koleksi digital dan undang-undang hak cipta
Authors: Wahdah Siti
Published: November 2021

Preliminary. Librarians as digital library managers need to pay attention to issues related to digital collections, including legal and regulatory issues related to intellectual property rights or copyrights related to taking and making digital collections and plagiarism.Method. This research is a qualitative type with a descriptive approach. The data was obtained using a literature study technique by searching the latest journal articles and books.Data analysis. By using four stages, namely data collection, data reduction, data presentation and the last step is drawing conclusions and verification.Results and Discussion. In connection with the copyright, in accordance with the provisions of the library legislation, in carrying out the task of digitizing the collection, there will be no problem and conflict with the legal provisions of copyright as long as the purpose is only for educational and research purposes, and not for commercial purposes.Conclusion. Libraries as information processing institutions can make institutional regulations to address copyright issues related to legal issues such as regulations: Deposit Trade-Secrecy, Copy Left, Doktrin Fair Use.
Proses digitalisasi naskah kuno sebagai pelestarian informasi di Museum Bandar Cimanuk Indramayu
Authors: Khadjah Ute Lies Siti , Perdana Fitri , Kirana Sarasvathi Desak Gde Delonix Regia , Winoto Yunus
Published: November 2021

Introduction. One of the most valuable cultural heritage of the Indonesian nation's ancestors is the ancient manuscript. Ancient manuscripts can be found in every region in Indonesia, especially Indramayu. Most of the ancient manuscripts found in Indramayu have been kept at the Bandar Cimanuk Museum, Indramayu. Most of the ancient manuscripts in the Bandar Cimanuk Museum, Indramayu, are written by hand or in the original form before printing. Digitalization is the process of transferring document media from printed, audio, and video forms. Equipment used in digitizing activities includes software and hardware. In digitizing ancient manuscripts, there are 2 stages that must be followed, pre-digitization and organizing.Data Collection Methods. Using a qualitative methods and descriptive  approach with a case study category. Data Analysis. The survey data were descriptively analysed by using 3 steps there are reduction, presentation and conclutsin . Result and Discussion.The result of the process of digitizing an ancient manuscript is an ancient manuscript in digital format. The results show that after the ancient manuscripts in the museum have been digitized, they can provide information according to the needs of the manuscript users and can preserve the information contained in the ancient manuscripts found at the Bandar Cimanuk Museum, Indramayu.Conclusion. Based on the results that have been found in digitizing ancient manuscripts at the Bandar Cimanuk Museum, Indramayu, there are a number of stages that must be carried out, namely the pre-digitalization stage and the organizing stage.
On the Biological Importance, Preparation, and Uses of Imidazo[1,2-b]pyridazine-Based Compounds
Authors: AKKURT Barbaros
Published: November 2021

While studying several pyridazine compounds, the author discovered imidazo[1,2-b]pyridazine (IMP), which is a very versatile compound class. It has been an inhibitor for many enzymes and also it is used as a brominating reagent in organic syntheses. Owing to its high biological activity, researchers have always considered including this molecule in their final structures. This humble attempt just aims to introduce this very powerful molecule to the readers, primarily of chemical origin, and should not be considered as a full treatise of, especially, the medicinal chemistry of the molecule. This work discusses the inhibitory effects, organic chemistry, applications in material chemistry, and theoretical studies of IMP and related molecules. The readers are hereby encouraged to work with medicinal chemists with the newly prepared molecules including this and similar molecules, in the struggle with many diseases like cancer, Alzheimer’s, and others.
Kamcili-Yildiz, Naciye (2021). Zwischen Glaubensvermittlung und Reflexivität. Eine quantitative Studie zu professionellen Kompetenzen von islamischen ReligionslehrerInnen (Internationale Hochschulschriften 682). Münster: Waxmann. ISBN 978-3-8309-4295-5. 276 Seiten.
Authors: Bubenheim Julia
Published: November 2021

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Eine studentische Studie zur kirchlichen Umweltarbeit oder: Schöpfungstheologie im Umweltschutz entdecken
Authors: Ziermann Simone
Published: November 2021

In dem Text werden Ergebnisse einer Pilotstudie zum kirchlichen Umweltengagement in den Ortsgemeinden vorgestellt. Die Studie wurde im Rahmen einer Lehrveranstaltung als „Forschendes Lehren und Lernen“ durchgeführt und von Studierenden mitverantwortet. Der Erkenntnisgewinn bewegt sich deshalb auf zwei unterschiedlichen Ebenen: Zum einen bewährt sich das Gespräch/Interview als hochschuldidaktische Me­thode; zum anderen ergibt sich ein inhaltlicher Ertrag zur kirchlichen Umweltarbeit in den Ortsgemeinden: Die Schöpfungstheologie, die dort zugrunde gelegt wird, ist zwar auf den ersten Blick eher eindimensional, auf den zweiten Blick zeigt sich aber ein breites Spektrum von theologischen Fragestellungen und Überlegungen. Hier ließe sich mit religionspädagogischen Angeboten gezielt anknüpfen. Inhaltlich rücken dabei vor allem die theologische Sündenlehre, der kategoriale Bruch zwischen Welt und Eschaton sowie die Bedeutung der Mensch-Tier-Beziehung ins Blickfeld.
Burke, Andree / Hiepel, Ludger / Niggemeier, Volker / Zimmermann, Barbara (Hg.) (2021). Theologiestudium im digitalen Zeitalter. Stuttgart: Kohlhammer. ISBN 978-3-17-038893-2. 364 Seiten.
Authors: Menne Andreas
Published: November 2021

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Acessibilidade Web dos sites das bibliotecas das Universidades Federais do Estado de Minas Gerais
Authors: Souza Marcos de , Almeida Fernanda Gomes
Published: November 2021

Introdução/Objetivo: Pesquisa de natureza mista que teve como objetivo verificar se os sites das bibliotecas das Universidades Federais do Estado de Minas Gerais estão adequados quanto aos recursos de acessibilidade Web. Metodologia: Na etapa 1 foi realizada pesquisa bibliográfica em livros e periódicos e também uma pesquisa documental por leis, decretos e sites governamentais que versam sobre acessibilidade. Na etapa 2 foram selecionadas como amostra as 11 Universidades Federais do Estado de Minas Gerais, onde foi solicitado, por e-mail e plataforma Fala.BR, o quantitativo de discentes matriculados, bem como o número de discentes que se declaram com algum tipo de deficiência. Na etapa 3 foi realizada, nos sites das bibliotecas das 11 instituições da amostra, avaliação automática de acessibilidade Web utilizando o serviço Assistente de Simulador de Acessibilidade de Sítios (ASES) e; avaliação heurística de acessibilidade Web por meio de diretrizes de acessibilidade criando, ao final da avaliação por heurísticas, uma lista de sete elementos já implementados ou que poderiam ser implementados nos sites das bibliotecas, sendo eles: 1) descrição de acessibilidade; 2) menu de salto; 3) contraste; 4) tamanho da fonte; 5) navegação por teclas; 6) Vlibras e; 7) áudio do texto. Resultados: A pesquisa indicou baixo percentual de Pessoas com Deficiências inseridas nas universidades mineiras, se comparado ao Censo 2010. Entretanto, isso não é motivo para que as universidades deixem de aperfeiçoar os recursos de acessibilidade Web em seus respectivos sites. Muito pelo contrário, as universidades podem desenvolver recursos acessíveis que atendam diferentes necessidades/níveis de Pessoas com Deficiências. Conclusão: A combinação entre as técnicas de avaliação, automática e heurística são fundamentais para uma análise mais completa da acessibilidade Web.
Living-donor fresh parathyroid tissue allotransplantation as treatment for permanent hypoparathyroidism: case report
Authors: Gadelha Daniel Duarte , Alves Filho Wellington , Brandão Marjorie Azevedo Jales , Oliveira Claudia Maria Costa de , D'Alva Catarina Brasil , Fernandes Virgínia Oliveira , Montenegro Junior Renan Magalhães
Published: November 2021

Introduction: the standard hypoparathyroidism treatment consists of replacing calcium and active vitamin D (calcitriol), but it does not correct the underlying abnormality, parathyroid hormone (PTH) deficiency. Both the disease and its treatment are responsible for many morbidities that affect multiple organs and systems. Therefore, parathyroid allotransplantation has been described as an alternative treatment option, especially in refractory cases. Objectives: to verify if parathyroid allotransplantation is effective as a treatment for permanent hypoparathyroidism. Methodology: fresh parathyroid tissue was obtained from a 36-year-old male with a past medical history of hyperparathyroidism secondary to end-stage renal disease and immediately implanted in the recipient’s non-dominant forearm, a 57-year-old female with refractory hypoparathyroidism, despite high doses of calcium and calcitriol replacement. Corticosteroid immunosuppression was performed for 10 days. Results: the allograft showed no evidence of functionality eleven months after transplant. The procedure was considered safe. Conclusion: more studies are required to validate this technique and improve its results.
Thinking Process Profile of Senior High School Students in Physics Problem-Solving: Terms of Differences in Emotional Intelligence Levels and Gender
Authors: Prahani Binar Kurnia , Kristiyanto Wahyu Hari , Siswanto Joko , Saputro Budiyono , Mubarok Husni
Published: November 2021

This literature study aims to obtain the thinking process profile of senior high school students in physics problem-solving based on differences in emotional intelligence levels and gender. In this study used literature study method with phenomenological analysis, functionalism analysis, and critical analysis. The sources used to compile this article include some literature on emotional intelligence, gender effect, thinking process, problem-solving, and several empirical study on students in physics problem-solving, especially in senior high school. The authors summed up the conclusions based on the results of the literature study as follows: (1) The profile of the thinking process is influenced by emotional intelligence level and gender; (2) Emotional intelligence is directly proportional to the thinking process of students in the process of solving physics problems; (3) Students who have high emotional intelligence are more likely to have high physics problem-solving skills; (4) Gender differences (male and female) in solving physics problems, generally, are still debatable, in which sense is it better? Then it further research needs that is valid and reliable to answer this question. (5) There is a strong tendency that the male gender is more resilient in dealing with and solving complex physics problems; (6) The gender of female students is superior in solving physics problems that require very high detail. The main implication of this article is to obtain the thinking process profile of senior high school students in physics problem-solving based on terms of differences in emotional intelligence levels and gender.
Perioperative Botulinum Toxin A in the Surgical Management of Seizure-Related Shoulder Instability
Authors: Edwards Matthew D. , Koontz Elizabeth H. , Revuelta Gonzalo J. , Edwards Jonathan C. , Slone Harris S. , Woolf Shane K.
Published: November 2021

Case:

A 20-year-old woman presented with recurrent bilateral shoulder instability concurrent with severe, treatment-refractory epilepsy. Imaging revealed glenoid bone loss of 25% to 28% and large Hill-Sachs defects bilaterally. Bone graft augmentation of the glenoid and infill of the Hill-Sachs defects was performed bilaterally. Perioperative neuromuscular paralysis of shoulder girdle muscles with botulinum toxin was performed to facilitate recovery. Both shoulders at 2.5 and 4 years, respectively, demonstrate excellent stability and radiographic union despite continued seizure activity.

Conclusion:

Perioperative neuromuscular paralysis with botulinum toxin may provide early graft protection after the surgical treatment of glenohumeral instability because of seizures.
The Coexistence of Spontaneous Femoral Nerve Palsy and Developmental Dysplasia of the Hip in a Breech-Presenting Newborn
Authors: Ertan Birsel Sema , Sarıkaya İlker Abdullah , Erdal Ozan Ali , Görgün Barış , İnan Muharrem
Published: November 2021

Case:

In this report, we present an infant who was diagnosed with femoral nerve palsy (FNP) and developmental dysplasia of the hip (DDH) on the same side after delivery. The patient was treated with hip alternative abduction orthosis, which did not force hip flexion with satisfactory results.

Conclusion:

FNP in newborns with DDH is usually described as a possible complication of the Pavlik harness treatment. However, there is only one report that presents 2 cases. Our objective is to raise awareness of this very rare condition because performing an early intervention is vital to achieving an optimal therapeutic result.
Endoscopic Shelf Procedure and Ischiofemoral Decompression with Arthroscopic Acetabular Labral Reconstruction
Authors: Maldonado David R. , Owens Jade S. , Jimenez Andrew E. , Saks Benjamin R. , Lall Ajay C. , Domb Benjamin G.
Published: November 2021

Case:

A 43-year-old female patient complained of pain in the right hip. The diagnoses of hip dysplasia, ischiofemoral impingement (IFI), femoroacetabular (FAI) cam-type morphology, and labral tear were made. The patient underwent hip arthroscopy with labral reconstruction for an irreparable labral tear and cam-morphology correction, and hip endoscopy for shelf procedure and ischiofemoral decompression. Favorable outcomes were reported at 1-year follow-up.

Conclusion:

Hip arthroscopy for FAI cam-type morphology with labral reconstruction and concomitant hip endoscopy for shelf and ischiofemoral decompression seem to be safe for the treatment of active young adult patients with FAI cam-type morphology, irreparable labral tear, dysplasia, and IFI diagnoses. Nevertheless, the results presented should not be extrapolated as this is a case report.
Plate-Tensioned-Nail for Salvage of Failed Subtrochanteric Intramedullary Motorized Limb Lengthening
Authors: Patterson Joseph T.
Published: November 2021

Case:

A 43-year-old insulin-dependent man with a 4.4-cm posttraumatic femoral limb length discrepancy sustained a subtrochanteric femur fracture associated with failure of a motorized intramedullary limb lengthening nail during distraction osteogenesis. The patient requested a single-stage salvage operation. After implant removal, the femur was stabilized and compressed with a plate-tensioned-nail construct consisting of 4.5-mm locking compression plate tensioned and linked to a femoral reconstruction nail through interlocking screws with immediate weight-bearing.

Conclusion:

A plate-tensioned-nail construct is a single-stage salvage option for a length-unstable subtrochanteric nonunion which permits immediate full weight-bearing.
Spinal Hypertrophic Pachymeningitis Causing Thoracic Myelopathy in a Patient of Takayasu Arteritis
Authors: Murugan Chandhan , Kavishwar Rohit Akshay , Ramachandran Karthik , Shetty Ajoy Prasad , B. T. Pushpa , Rajasekaran S.
Published: November 2021

Case:

A 52-year-old man presented with thoracic myelopathy, and his magnetic resonance imaging (MRI) was suggestive of T1-T4 hypertrophic-pachymeningitis. Incidentally, circumferential thickening of the infra-renal abdominal aorta and right common iliac artery was seen, which along with the findings in a contrast computed tomography was consistent with Takayasu arteritis (TA). The patient underwent T1-T4 laminectomy, thinning of dura, biopsy, and steroid therapy. At the 1-year follow-up, he was asymptomatic and MRI revealed resolution of the lesion.

Conclusion:

This is the first report describing an association between TA and hypertrophic spinal pachymeningitis, emphasizing the unusual neurological manifestation of myelopathy and complete resolution of symptoms with timely and appropriate intervention.
Injury to the Meniscofemoral Portion of the Deep MCL Is Associated with Medial Femoral Condyle Bone Marrow Edema in ACL Ruptures
Authors: Moran Jay , Katz Lee D. , Schneble Christopher A. , Li Don , Kahan Joseph B. , Wang Annie , Porrino Jack , Jokl Peter , Hewett Timothy E. , Medvecky Michael J.
Published: November 2021

Background:

The primary goal of the present study was to investigate injury to the deep medial collateral ligament (MCL), specifically the meniscofemoral ligament (MFL) portion, and its association with medial femoral condyle (MFC) bone marrow edema in acute anterior cruciate ligament (ACL) ruptures. The secondary goal was to examine the association between MFL injury and medial meniscal tears (MMTs) in these same patients.

Methods:

Preoperative magnetic resonance imaging (MRI) scans of 55 patients who underwent ACL reconstruction surgery were retrospectively reviewed by 2 board-certified musculoskeletal radiologists. MRI scans were examined for MFC edema at the insertion site of the MFL. This site on the MFC was referred to as the central-femoral-medial-medial (C-FMM) zone based on the coronal and sagittal locations on MRI. The presence or absence of bone marrow edema within this zone was noted. The prevalence, grade, and location of superficial MCL and MFL injuries were also recorded on MRI. The correlations between MFL injuries and the presence of MFC bone marrow edema were examined. Lastly, the presence and location of MMTs were also recorded on MRI and were confirmed on arthroscopy, according to the operative notes.

Results:

On MRI, 40 (73%) of the 55 patients had MFL injuries. MFL injuries were significantly more common than superficial MCL injuries (p = 0.0001). Of the 27 patients with C-FMM bruising, 93% (25 patients) had MFL tears (p < 0.00001). In addition, of the 40 patients with an MFL injury, 63% (25 patients) had C-FMM bruising (p = 0.0251). Chi-square testing showed that MMTs and MFL injuries were significantly associated, with 12 (100%) of 12 patients with MMTs also having a concomitant MFL injury (p = 0.0164).

Conclusions:

The prevalence of MFL injury in ACL ruptures is high and MFC bone marrow edema at the MFL insertion site should raise suspicion of injury. MFL injuries can present with clinically normal medial ligamentous laxity in ACL ruptures. Additionally, MFL injuries were significantly associated with posterior horn MMTs, which have been shown in the literature to be a potential risk factor for ACL graft failure.

Clinical Relevance:

As deep MCL injuries are difficult to detect on physical examination, our findings suggest that the reported MFC edema in ACL ruptures can act as an indirect sign of MFL injury and may aid in the clinical detection. Additionally, due to the anatomical connection of the deep MCL and the meniscocapsular junction of the posterior horn of the medial meniscus, if an MFL injury is suspected through indirect MFC edema at the insertion site, the posterior horn of the medial meniscus should also be assessed for injury, as there is an association between the 2 injuries in ACL ruptures.
Effect of Polar Molecule Aggregation on the Stability of Crude Oil/Water Interface: A Molecular Simulation Study
Authors: Zhao Xinming , Xia Minmin , Li Peng , Wang Jianwei , Xu Yunfei , Guo Shijun
Published: November 2021

To ensure the efficient operation of crude oil dehydration and sewage treatment technology in oilfield surface production system, the effect mechanism of polar components represented by asphaltene and resin on the formation and stability of oil-water emulsion needs to be revealed at nanoscale. In this paper, the molecular dynamics simulation method was used to construct the crude oil/polar component/water system models with different molar ratios of asphaltene to resin by adjusting the number of asphaltene and resin molecules, so as to reveal the molecular arrangement and aggregation process and film forming characteristics of asphaltene, resin, and their mixture at the oil-water interface. The simulated results showed that the aggregation process of asphaltene molecules under the influence of hydrogen bonds can be divided into three stages. The addition of resin molecules enhanced the connection between molecules of all polar components at the interface. The π−π stacking and T-shaped stacking structures were found in all aggregations, and the higher the molar ratio of asphaltene molecules, the higher the proportion of π−π stacking structure. With the increase of the molar ratio of asphaltene to resin increases from 0 : 1 to 1 : 0, the interfacial film thickness and interface formation energy increase from 2.366 nm and -143.89 kJ/mol to 3.796 nm and -304.09 kJ/mol, respectively, which indicated that asphaltene molecules play a more significant role in promoting the formation of interfacial film and maintaining its structural stability than resin molecules. The investigations in this study provide theoretical support for demulsification of the crude oil emulsion.
FBXW2 Inhibits Prostate Cancer Progression and Metastasis Via Promoting EGFR Ubiquitylation and Degradation
Authors: Zhou Tao , Chen Tingting , Lai Bin , Zhang Wenfeng , Luo Xi , Fu Weihua , Zhou Weihua , Xu Jie
Published: November 2021

Background: The process of ubiquitylation, carried out by a three-step enzymatic cascade, maintains the balance of intracellular proteins and the stability of their functions. FBXW2 is a novel F-box protein, and acts as a tumor suppressor gene in lung cancer by directly degrading substrates or regulating the other E3 ligases. However, whether or how FBXW2 regulates prostate cancer (PCa) tumorigenesis and progression is still unclear.Methods: The expression levels of FBXW2 in PCa tissues and matched non-tumor tissues were detected by immunoblotting and qPCR. Cell counting kit-8, wound-healing assay, invasion assay, apoptosis and cell cycle assays, and animal experiments were performed to identify the function of FBXW2 in PCa cells. Half-life analysis, immunoprecipitation, and the in vivo ubiquitylation assay were performed to determine how FBXW2 regulates EGFR and its downstream signaling pathway.Results: FBXW2 expression was lowly expressed in highly-progressive PCa tissues and PCa cell lines. Augmented FBXW2 expression suppressed PCa cell progression and metastasis by repressing EGFR downstream proteins, while FBXW2 depletion had opposite effects. Overexpression of FBXW2 inhibited tumor growth, and even osteolytic bone destruction. Furthermore, FBXW2 and EGFR protein levels were inversely correlated in PCa cell lines and patient tumor tissues. EGFR protein level and its half-life was extended by FBXW2 depletion. While the basal level of EGFR was decreased, and its half-life was shortened upon overexpression of FBXW2-WT but not its dominant negative mutant. Intriguingly, FBXW2 promoted EGFR ubiquitylation and degradation via its binding motif (TSNNST) on EGFR, thereby elevated FBXW2 abrogated the PCa cell growth and metastasis caused by EGF stimulation.Conclusions: Collectively, our data shows that FBXW2 inhibits PCa cell progression and metastasis by promoting EGFR ubiquitylation and degradation, and would be a novel tumor suppressor for PCa.
High Rates of Blood Transfusion Associated with Parkinson’s Disease
Authors: Shahrestani Shane , Tafreshi Ali R. , Brown Nolan , Dashtipour Khashayar
Published: November 2021

ImportanceAs evidence continues to accumulate regarding the multi-organ dysfunction associated with Parkinson’s Disease (PD), it is still unclear as to whether PD increases the risk of hematological pathology. ObjectiveTo investigate the association between PD and hematological pathology and relevant risk factors.Design, Setting, and ParticipantsThis retrospective cohort analysis was conducted using 8-years of the National Readmission Database. All individuals diagnosed with PD were queried at the time of primary admission, and all relevant demographic data was collected. Readmissions, complications, and risk factors were analyzed at 30, 90, 180, and 300-day intervals. Statistical analysis included multivariate gaussian-fitted modelling, with age, sex, comorbidities, and discharge weights as covariates. Coefficients of model variables were exponentiated and interpreted as odds ratios. Predictive models were developed using generalized linear modeling. Complications were queried using International Classification of Disease codes.Main Outcomes and MeasuresReadmission for blood transfusion within readmission intervals and potential risk factors for blood transfusion. ResultsAnalysis was with 1,765,800 PD patients (mean age: 76.3±10.4; 44.1% female). Rates of percutaneous blood transfusion in readmitted patients at 30, 90, 180, and 300 days was found to be 8.7%, 8.6%, 8.3%, and 8.3% respectively. At all timepoints, modelling revealed that those with anti-parkinsonism medication side effects at the primary admission had increased rates of gastrointestinal (GI) hemorrhage (average OR: 1.02; 95%CI: 1.01-1.03, p<0.0001) and blood transfusion (average OR: 1.06; 95%CI: 1.05-1.08, p<0.0001) at readmission. PD patients who experienced GI hemorrhage of any etiology, including as a side effect of anti-parkinsonism medication, were found to have significantly higher rates of blood transfusion at all timepoints (average OR: 1.14; 95%CI: 1.13-1.16, p<0.0001). Kaplan-Meier survival analysis and predictive modelling confirmed these findings, with significantly higher rates of blood transfusion seen in PD patients with drug side effects and GI hemorrhage compared to those without.Conclusions and RelevanceOur findings suggest that PD patients may be readmitted at a high rate for blood transfusion procedures. These readmissions were found to be significantly associated with anti-parkinsonism drug side effects and GI hemorrhage of any etiology. Long-term management of PD patients should focus on both neurological and non-neurological complications.
Nuclear morphology is a deep learning biomarker of senescence across tissues and species
Authors: Heckenbach Indra , Mkrtchyan Garik , Ezra Michael Ben , Bakula Daniela , Madsen Jakob , Nielsen Malte , Oró Denise , Idda M Laura , Gorospe Myriam , Mortensen Laust , Verdin Eric , Westendorp Rudi , Scheibye-Knudsen Morten
Published: November 2021

Cellular senescence is a critical component of aging and many age-related diseases, but understanding its role in human health is challenging in part due to the lack of exclusive or universal markers. Using neural networks, we achieve high accuracy in predicting senescence state and type from the nuclear morphology of DAPI-stained human fibroblasts, murine astrocytes, murine neurons, and fibroblasts derived from premature aging diseases in culture. After generalizing this approach, the predictor recognizes an increasing rate of senescent cells with age in H&E-stained murine liver tissue and human dermal biopsies, suggesting that alterations in nuclear morphology is a universal feature of senescence. Evaluating corresponding medical records reveals that individuals with a higher rate of senescent cells have a significantly decreased rate of malignant neoplasms, lending support for the protective role of senescence in limiting cancer development. Additionally, we find a positive association with lower significance for other conditions, including osteoporosis, osteoarthritis, hypertension, cerebral infarction, hyperlipidemia, and hypercholesteremia. In sum, we introduce a predictor of cellular senescence based on nuclear morphology that is applicable across tissues and species and is associated with health outcomes in humans.
Using Machine Learning to Identify At-risk Students in an Introductory Programming Course
Authors: Cooper Cameron I. , Cooper Kamea J.
Published: November 2021

Nationally, more than one-third of students enrolling in introductory computer science programming courses (CS101) do not succeed. To improve student success rates, this research team used supervised machine learning to identify students who are “at-risk” of not succeeding in CS101 at a two-year public college. The resultant predictive model accurately identifies \(\approx\)99% of “at-risk” students in an out-of-sample test data set. The programming instructor piloted the use of the model’s predictive factors as early alert triggers to intervene with individualized outreach and support across three course sections of CS101 in fall 2020. The outcome of this pilot study was a 23% increase in student success and a 7.3 percentage point decrease in DFW rate. More importantly, this study identified academic, early alert triggers for CS101. Specifically, the first two graded programs are of paramount importance for student success in the course.
Chromatin Reader Dido3 Regulates the Genetic Network of B Cell Differentiation
Authors: Burgo Fernando Gutiérrez del , Pons Tirso , de Luis Enrique Vázquez , Martínez-A Carlos , Villares Ricardo
Published: November 2021

BACKGROUNDThe development of hematopoietic lineages is based on a complex balance of transcription factors whose expression depends on the epigenetic signatures that characterize each differentiation step. The B cell lineage arises from hematopoietic stem cells through the stepwise silencing of stemness genes and balanced expression of mutually regulated transcription factors, as well as DNA rearrangement, in a complex process involving epigenetic remodeling.RESULTSHere we report the impact on B cell differentiation of the lack of DIDO3, a reader of histone post-translational modifications, in the mouse hematopoietic compartment. We found reduced DNA accessibility in hematopoietic precursors, leading to a severe deficiency specifically in the generation of successive stages of B-cell differentiation. The expression of essential transcription factors and differentiation markers is impaired, as is the process of somatic recombination. DIDO3-deficient cells show transcriptional alterations of a number of polycomb repressive complex 2, suggesting the involvement of DIDO3 in determining the specific activity of PRC2 in the B cell lineage, including VH-DJH rearrangement. CONCLUSIONSTaken together, our data suggest that DIDO3 is an epigenetic reader involved in the specific differentiation of B cell precursors in the hematopoietic compartment of mice.
A Case Report of Chronic Expanding Hematoma of the Left Erector Spinae Muscle After Stereotactic Body Radiotherapy for Renal Cell Carcinoma
Authors: Ishikawa Yojiro , Umezawa Rei , Yamamoto Takaya , Takahashi Noriyoshi , Takeda Kazuya , Suzuki Yu , Jingu Keiichi
Published: November 2021

Background: Hematomas that slowly increase in size for over a period of more than one month after the initial hemorrhage are referred to as chronic expanding hematoma (CEH). We report a case of CEH of left erector spinae muscle after stereotactic body radiotherapy (SBRT) for renal cell carcinoma (RCC). Case presentation: A 74-year-old Japanese male complained of back pain. There was no history of surgery or trauma of his back. He received SBRT for RCC of left kidney of seven years ago. Computed tomography (CT) revealed the left erector spinae muscle was swollen compared to the contralateral side at the third lumbar level. Ultrasonography showed a tumor of 30 mm in size without blood flow in left paraspinal muscle. Positron emission tomography-CT revealed uptake in the left paraspinal muscle. Pathological examination showed radiation-induced CEH. We performed conservative therapy with medication alone because the tumor had been gradually growing. One year after starting observation, the patient died due to subdural hemorrhage after a fall and progression of renal failure. Discussion and conclusions: Because this study was a case study, it is difficult to definite the CEH after SBRT. Since SBRT has recently been increasing, SBRT-induced CEH is considered to be an important complication.
Neuroendocrine Carcinoma of the Cervix: Clinicopathologic Study and Review of the Literature
Authors: Zhang Xiaobo , Xu Yougui , Shen Danhua , LI MingZhu
Published: November 2021

BackgroundNeuroendocrine carcinoma of the cervix (CNECC) is a rare variant of cervical cancer. The prognosis of women with CNECC is poor and there is no standardized therapy for this type of malignancy. To discuss the clinical and pathological features and prognosis of CNECC.MethodsTwenty one patients diagnosed as CNECC of cervix from May 2008 to September 2021 were retrospectively analyzed at Peking University people's hospital, were analyzed retrospectively including hematoxylin-eosinstaining （HE）slides review, immunohistochemistry results,Thinprep cytology test(TCT) and human papillomavirus (HPV) Hybrid Capture 2(HC2) assay. and their data were analyzed retrospectively. Telephone and medical records were followed up for 3-160 months with an average follow-up time of 49.8 month.ResultsThe patient's average age was 48.6 years old (range: 33–69 years). The first symptoms of 11 cases had vaginal bleeding, 2 cases had vaginal discharge, and the others were asymptomatic. Among the 21 patients, 17 cases were diagnosed as neuroendocrine carcinoma by biopsy. There were 9 cases with TCT examination and HC2 tests before biopsy, TCT results of 4 cases were positive. High-risk HPV of 7 cases were positive. The morphology of cancer cells were relatively consistent, the cytoplasm was sparse, the nuclei were obviously blue stained, and accompanied by extensive neoplastic necrosis. 13 cases were pure CNECC(61.9%), 8 cases were mix types of CNECC(38.1%).There were 3 cases accompanied by squamous cell carcinoma,5 cases accompanied by adenocarcinoma.The positive detection rate of Syn, CgA, CD56,p16 and TTF1 were 85.7%(18/21), 42.9%(9/21), 85.7% (18/21), 81%(17/21) 52.4%(11/21),respectively.The overall survival rate of 21 NECC cases was 71.4%(15/21).ConclusionsCNECC was a extremely rare primary tumor.The tumor was associated with HPV infection. Combined examination of TCT and HPV could significantly improve the detection rate of neuroendocrine carcinoma before biopsy.Pthology diagnosis was based on histological and immunohistochemical examination. It was considered to be highly aggressive malignancy with very poor prognosis.
Effect of Insulin Resistance on Recurrence After Radiofrequency Catheter Ablation in Patients with Atrial Fibrillation
Authors: Wang Zhe , Wang Yi-Jia , Liu Zhi-Yu , Li Qing , Kong Ya-wei , Chen Ying-Wei , Sun Yi-Hong , Dong Jian-Zeng
Published: November 2021

Background Recurrence after atrial fibrillation(AF) ablation has many risk factors. the relationship between the recurrence rate after ablation and IR in the non-diabetic patients with AF is not clear.MethodsRetrospective cohort study enrolled AF patients without diabetes who underwent ablation between 2018~2019 in the first affiliated hospital of zhengzhou university. Homeostasis model assessment of insulin resistance (HOMA‐IR) was calculated and a value of ≥2.69 was defined as insulin resistant(IR). The patients were categaried into two groups: those with HOMA‐IR<2.69 in group 1(n=163); HOMA‐IR≥2.69 in group 2 (n=69). Multivariable adjusted Cox proportional hazard models were performed to compare the risk of AF recurrence after ablation. The definition of AF recurrence was documented AF, atrial flutter, or atrial tachycardia lasting >30 seconds recorded in ECG or 24‐hour Holter monitoring after 3 months blanking period.Results232 AF patients receiving ablation were enrolled and the median age was 59.5±11.3 years . There were 166 cases of paroxysmal AF and 66 cases of persistent AF. Patients with IR (n=69)were more likely to have Dyslipidemia, higher fasting blood glucose and fasting insulin than those in non-IR group. Patients with IR also were more likely to recieve antiarrhythmic drugs before ablation. After a mean follow‐up of 322±85 days, 62(26.7%) patients had documented recurrence of AF. Multivariable analysis showed that HOMA-IR value and left atrial diameter（LAD）were independent risk factors for recurrence after AF ablation (HR: 1.259, 95% CI:1.086~1.460, P=0.002; HR: 1.043, 95% CI:1.005~1.083, P=0.025; respectively).ConclusionsHOMA-IR and LAD are independent risk factors for AF recurrence after ablation in patients without diabetes.
Linc01018 / hsa-mir-182-5p / ADH4 Axis Study on the Role and Mechanism in the Occurrence and Development of Liver Cancer
Authors: Wang Liting , Chen Zhen-yu , Wang Xiao-ling , Zeng Qiu-ling , Jiang Shao-lan , Li Xiao-long
Published: November 2021

Background

To construct the lncRNA-miRNA-mRNA axis based on the study of molecular oncology, to explore the role and mechanism of this axis in the occurrence and development of liver cancer, so as to provide a new channel for the treatment of liver cancer.
Methods

Using public online databases to establish lncRNA-miRNA-mRNA ceRNA regulation network, after which using QPCR and other experimental techniques to verify that this axis is established and the mechanism of participating in the development of liver cancer.
Results

It can be concluded from database mining that the expressions of hsa-miR-182-5p and ADH4 are negatively correlated in hepatocellular carcinoma, and LINC01018 is also negatively correlated hsa-miR-182-5p-ADH4, indicating that LINC01018, hsa-miR-182-5p and ADH4 are strongly correlated. Constitute the regulatory axis to participate in the occurrence and development tendency of tumors. LINC01018 regulates ADH4 to inhibit LIHC cell growth by inhibiting hsa-miR-182-5p, providing a feasible theoretical basis for the treatment of HCC.The regulatory axis may also regulate the occurrence and development tendency in liver cancer by adjusting the expression levels of key proteins and phosphorylation proteins in GO and KEGG signaling pathways.
Conclusions

In this study, it was found that LINC01018/hsa-miR-182-5p/ADH4 ceRNA regulatory axis exists in the human body, and this axis has the possibility of becoming an immune checkpoint inhibitor for liver cancer, which is regarded as a new entry point in the diagnosis and therapy of liver cancer.
Activation of NRF2/FPN1 Pathway Attenuates Myocardial Ischemia-reperfusion Injury in Diabetic Rats by Regulating Iron Homeostasis and Ferroptosis
Authors: tian hao , Xiong Yonghong , Zhang Yi , Leng Yan , Tao Jie , Li Lu , Qiu Zhen , Xia Zhongyuan
Published: November 2021

Purpose Myocardial ischemia-reperfusion injury (IRI) can further worsen cardiac function in ischemic heart disease, and diabetes can increase susceptibility to myocardial IRI. Disorders of iron metabolism are involved in the pathological mechanisms of the most common diseases, such as diabetes, obesity, coronary artery angioplasty, or heart transplantation. Ferroportin1 (FPN1) is the only protein known to be associated with iron release in mammals and is regulated by nuclear factor E2-related factor 2 (NRF2) at the transcriptional level, thus playing an important role in iron homeostasis. Therefore, this study tested whether NRF2/FPN1 pathway plays a beneficial role in the treatment of diabetic myocardial IRI and potential detailed mechanism. Methods In this study, we investigated the effects of ferroptosis in STZ-induced diabetic rats following myocardial IRI in vivo, and its alteration in glucose and hypoxia/reoxygenation-induced cardiomyocytes injury in vitro. Results Cardiac functional and structural damage was detected by Evans blue/TTC double staining, Echocardiography, HE staining and serological indices, CCK-8 assay and ROS production to measure cardiomyocyte viability and oxidative stress level. Additionally, the changes in cell supernatant levels of Fe2+, SOD, MDA, and mRNA and protein expression of ferroptosis marker proteins confirmed the beneficial effects of the NRF2/FPN1 pathway on diabetic myocardial IRI related to iron metabolism and ferroptosis. Conclusions Overall, we find that iron homeostasis-related ferroptosis plays an important role in aggravating myocardial IRI in diabetic rats, and NRF2/FPN1 pathway-mediated iron homeostasis and ferroptosis might be a promising therapeutic target against myocardial IRI in diabetes.
L-Arginine Alleviates LPS-induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells
Authors: Zhao Ye , Jiang Qin , Zhang Xuefei , Zhu Xiaoxiao , Dong Xia , Shen Linyuan , Zhang Shunhua , Niu Lili , Chen Lei , Zhang Ming , Jiang Jun , Chen Daiwen , Zhu Li
Published: November 2021

BackgroundAs a highly plasticized tissue, muscle could exert a spontaneous immune behavior in response to external pathogen stimulation. L-arginine (L-Arg) has been reported to possess a wide range of functions, including anti-inflammatory, anti-oxidative, and anti-apoptosis. However, the role of L-Arg in LPS-induced muscle injury and its potential protective mechanism has not been well elucidated. This study aimed to investigate the effects of L-Arg on the LPS-induced oxidative stress and apoptosis in vitro models of well-differentiated C2C12 myotube cells. ResultsIn the present study, we first demonstrated that myotube cells treated with 0.2 mg/mL lipopolysaccharide (LPS) significantly decreased cell viability. Then, different concentrations of L-Arg (0, 0.5, 2.5, 5 mM)-pretreated myotube cells were exposed to LPS. The results showed that L-Arg treatment significantly suppressed reactive oxygen species (ROS) accumulation and cell apoptosis. Furthermore, L-Arg improved antioxidant-related enzymes’ activities; increased antioxidant ability via Akt-Nrf2 signaling pathway; maintained the mitochondrial membrane potential (MMP) and enhanced forkhead box protein 3a (FOXO3a) expression, lead to a decrease in the mitochondrial-associated apoptotic proteins. In addition, L-Arg exposure dramatically increased the mRNA and protein expressions of Sirtuin1 (SIRT1). The cytoprotective effect of L-Arg was restricted by the SIRT1 inhibitor EX527, which led to an increase in ROS level, apoptosis rate, and decreased cell MMP. The results also demonstrated that EX527 treatment significantly eliminated the effect of L-Arg on LPS-induced oxidative damage and mitochondria-mediated cell apoptosis. ConclusionsOur findings revealed that L-Arg could be used as a potential nutraceutical in reducing muscle injury via regulating SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways.