bluuebunny/crossref_metadata_2025 huggingface dataset:
Complementary food exposure and children’s early understanding of food words: the approaching eating through language (APPEAL) study
Authors: Shapiro Allison L. B. , Lawless Megan C. , Charlifue-Smith Renee , Johnson Susan L.
Published: May 2024

Introduction

Language skills, such as the ability to understand words (receptive language), develop during infancy and are built through interactions with the environment, including eating. Exposure to complementary foods also begins in infancy and may play a significant role in language development, especially in understanding of food-related words. However, the relationship between the complementary foods to which a child is exposed and early language acquisition has not been previously studied. We hypothesized that young children’s food-related receptive language (FRL) would reflect the complementary foods to which they were frequently offered by caregivers.

Methods

Caregivers of young children (4-26 months; n = 408) in the Approaching Eating through Language (APPEAL) Study in the US were surveyed via Qualtrics. FRL was assessed by caregiver-report via a modified MacArthur-Bates Communicative Development Inventory. Complementary foods offered (CFO) by caregivers were assessed using a modified Food Frequency Questionnaire. Latent Class Analysis (LCA) was implemented to identify, 1) groupings of foods frequently offered (>1x/week) and 2) groupings of food-related words understood by the young children.

Results

A 5-class best fit LCA model was identified for CFO (-log likelihood [-llik]=-8727) and for FRL (-llik=-5476). Cross-classification of the CFO and FRL derived classes revealed that children with higher exposure to complementary foods were perceived by caregivers to be most likely to also understand a greater number of food-related words (Probability=0.48). As expected, children having been offered a greater number of complementary foods and who understood a greater number of food-related words were older, compared to those with less complementary food exposure and food-related language acquisition (p < 0.001).

Discussion

These findings support the potential role of introduction to complementary foods in development of food-related language.
Inflammatory myofibroblastic tumor in the liver: a case report
Authors: Meng Yinying , Xie Jinlan , Liang Yan , Wu Mulan , Lu Yi , Lu Qian
Published: May 2024

Background

Hepatic inflammatory myofibroblastic tumor (IMT) is an infrequent tumor with potential malignancy. However, it lacks specific clinical symptoms and usual imaging features.

Case presentation

A 34-year-old woman had a six-month history of fever and on-and-off pain in the upper right part of her abdomen that lasted for two weeks. Imaging tests revealed a liver mass initially thought to be liver malignancy, but subsequent histopathological examination after liver removal confirmed the diagnosis as hepatocellular inflammatory myofibroblastic tumor (HIMT).

Conclusion

Hepatic inflammatory myofibroblastic tumor (IMT) is an uncommon growth with vague clinical symptoms and lab results. Surgical removal remains the primary treatment method, resulting in favorable prognostic outcomes.
Quantification of multiple steroid hormones in serum and human breast cancer tissue by liquid chromatography-tandem mass spectrometry analysis
Authors: Wang Feng , Eikeland Eline , Reidunsdatter Randi J. , Hagen Lars , Engstrøm Monica J. , Geisler Jürgen , Haanpää Mikko , Hämäläinen Esa , Giskeødegård Guro F. , Bathen Tone F.
Published: May 2024

Introduction

Systemic and local steroid hormone levels may function as novel prognostic and predictive biomarkers in breast cancer patients. We aimed at developing a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous measurement of multiple, biologically pivotal steroid hormones in human serum and breast cancer tissue.

Methods

The quantitative method consisted of liquid-liquid extraction, Sephadex LH-20 chromatography for tissue extracts, and analysis of steroid hormones by liquid-chromatography-tandem mass spectrometry. We analyzed serum and tissue steroid hormone levels in 16 and 40 breast cancer patients, respectively, and assessed their correlations with clinical parameters.

Results

The method included quantification of nine steroid hormones in serum [including cortisol, cortisone, corticosterone, estrone (E1), 17β-estradiol (E2), 17α-hydroxyprogesterone, androstenedione (A4), testosterone and progesterone) and six (including cortisone, corticosterone, E1, E2, A4, and testosterone) in cancer tissue. The lower limits of quantification were between 0.003–10 ng/ml for serum (250 µl) and 0.038–125 pg/mg for tissue (20 mg), respectively. Accuracy was between 98%-126%, intra-assay coefficient of variations (CV) was below 15%, and inter-assay CV were below 11%. The analytical recoveries for tissue were between 76%-110%. Tissue levels of E1 were positively correlated with tissue E2 levels (p<0.001), and with serum levels of E1, E2 and A4 (p<0.01). Tissue E2 levels were positively associated with serum E1 levels (p=0.02), but not with serum E2 levels (p=0.12). The levels of tissue E2 and ratios of E1 to A4 levels (an index for aromatase activity) were significantly higher in patients with larger tumors (p=0.03 and p=0.02, respectively).

Conclusions

The method was convenient and suitable for a specific and accurate profiling of clinically important steroid hormones in serum. However, the sensitivity of the profile method in steroid analysis in tissue samples is limited, but it can be used for the analysis of steroids in breast cancer tissues if the size of the sample or its steroid content is sufficient.
Quantifying fetal heart health in gestational diabetes: a new approach with fetal heart quantification technology
Authors: Zhang Pengjie , Fu Xinghui , Zhao Lijuan , Wang Lu , Wu Shuning , Liu Yanyan , Cheng Jingliang , Zhang Shan
Published: May 2024

Objective

This study aimed to assess the impact of gestational diabetes mellitus (GDM) on fetal heart structure and function using a technique called fetal heart quantification (Fetal HQ), with a focus on mitochondrial dynamics, which employs advanced imaging technology for comprehensive analysis.

Methods

A total of 180 fetuses with normal heart structures, aged 24–40 weeks of gestation, were examined. A 2–3 s cine loop in the standard four-chamber oblique view was captured and analyzed using the speckle-tracking technique with Fetal HQ. Various echocardiographic parameters were evaluated, including four-chamber view (4CV), global spherical index (GSI), global longitudinal strain (GLS), 24-segment spherical index (SI), ventricular fractional area change (FAC), cardiac output (CO), and stroke volume (SV). These parameters were compared between the GDM group and the control group during two gestational periods: 24+0 to 28+0 weeks and 28+1 to 40+1 weeks. Statistical analysis was performed using independent samples t-tests and Mann-Whitney U tests to identify significant differences.

Results

Twenty fetuses from mothers with GDM and 40 from the control group were recruited at 24+0 to 28+0 weeks. At 28+1 to 40+1 weeks, 40 fetuses from mothers with GDM and 80 from the control group were recruited. The fetal left ventricular global longitudinal function was similar between the GDM and control groups. However, compared to the controls, right ventricular function in the GDM group was lower only at 28+1 to 40+1 weeks. In the GDM group, the global spherical index (GSI) was lower than in the control group at 28+1 to 40+1 weeks (1.175 vs. 1.22; p = 0.001). There were significant decreases in ventricular FAC (38.74% vs. 42.83%; p < 0.0001) and 4CV GLS for the right ventricle (−22.27% vs. −26.31%; p = 0.005) at 28+1 to 40+1 weeks.

Conclusion

Our findings suggest that GDM is associated with decreased right ventricular function in the fetal heart, particularly during the later stages of pregnancy (28+1 to 40+1 weeks), compared to fetuses from healthy pregnancies. The Fetal HQ technique represents a valuable tool for evaluating the structure and function of fetal hearts affected by GDM during the advanced stages of pregnancy.
Comparative transcriptomic analysis revealed important processes underlying the static magnetic field effects on Arabidopsis
Authors: Zhou Xiujuan , Zhang Lin , Zhang Peng , Xu Hang , Song Jialei , Chang Yafei , Cai Tiantian , Xie Can
Published: May 2024

Static magnetic field (SMF) plays important roles in various biological processes of many organisms including plants, though the molecular mechanism remains largely unclear. Here in this study, we evaluated different magnetic setups to test their effects on growth and development on Arabidopsis (Arabidopsis thaliana), and discovered that plant growth was significantly enhanced by inhomogeneous SMF generated by a regular triangular prism magnet perpendicular to the direction of gravity. Comparative transcriptomic analysis revealed that auxin synthesis and signal transduction genes were upregulated by SMF exposure. SMF also facilitated plants to maintain the iron homeostasis. The expression of iron metabolism-related genes was downregulated by SMF, however, the iron content in plant tissues remains relatively unchanged. Furthermore, SMF exposure also helped the plants to reduce ROS level and synergistically maintain the oxidant balance by enhanced activity of antioxidant enzymes and accumulation of nicotinamide. Taken together, our data suggested that SMF is involved in regulating the growth and development of Arabidopsis thaliana through maintaining iron homeostasis and balancing oxidative stress, which could be beneficial for plant survival and growth. The work presented here would extend our understanding of the mechanism and the regulatory network of how magnetic field affects the plant growth, which would provide insights into the development of novel plant synthetic biology technologies to engineer stress-resistant and high-yielding crops.
Identification and expression profiling of SmGATA genes family involved in response to light and phytohormones in eggplant
Authors: Wang Yanyan , Li Xinyun , Mo Yunrong , Jiang Caiqian , Zhou Ying , Hu Jingyi , Zhang Youling , Lv Junheng , Zhao Kai , Lu Zhenya
Published: May 2024

GATA proteins are transcription factors of zinc finger proteins, which play an important role in plant growth development and abiotic stress. However, there have been no identification or systematic studies of the GATA gene family in eggplant. In this study, 28 SmGATA genes were identified in the genome database of eggplant, which could be divided into four subgroups. Plant development, hormones, and stress-related cis-acting elements were identified in promoter regions of the SmGATA gene family. RT-qPCR indicated that 4 SmGATA genes displayed upregulated expressions during fruit developmental stage, whereas 2 SmGATA genes were down-regulated expression patterns. It was also demonstrated that SmGATA genes may be involved in light signals to regulate fruit anthocyanin biosynthesis. Furthermore, the expression patterns of SmGATA genes under ABA, GA and MeJA treatments showed that the SmGATAs were involved in the process of fruit ripening. Notably, SmGATA4 and SmGATA23 were highly correlated with the expression of anthocyanin biosynthesis genes, light-responsive genes, and genes that function in multiple hormone signaling pathways and the proteins they encoded were localized in the nucleus. All these results showed GATA genes likely play a major role in regulating fruit anthocyanin biosynthesis by integrating the light, ABA, GA and MeJA signaling pathways and provided references for further research on fruit quality in eggplant.
Dysexecutive symptomatology in everyday functioning and academic achievement in adolescents
Authors: Pablo-Ríos María Victoria , Navarro-Asencio Enrique , Mateos-Gordo Patricia , García-Gómez Raquel , Porras-Truque Claudia , García Moreno Luis Miguel
Published: May 2024

Background

During the educational stage, academic achievement depends on various social, family, and personal factors. Among the latter, executive skills in everyday life play a significant role in dealing with the academic demands of adolescents. Therefore, the aim of this study is to ascertain the effects of executive symptomatology in everyday functioning on academic achievement in adolescents.

Method

The study involved 910 students aged between 13 and 15 years (M = 14.09, SD = 0.68) from both public and private schools in the Community of Madrid. The DEX, BDEFS-CA, and BRIEF-SR questionnaires were utilised to assess executive difficulties, while grades in language, mathematics, and natural sciences were used as a measure of academic achievement.

Results

The data revealed statistically significant differences in working memory, emotional control, materials organisation, and task completion. In relation to language and natural sciences subjects. In the case of mathematics, emotional control and task completion were significant variables.

Conclusion

Our results indicate that certain executive skills that are manifested in everyday life activities can contribute, albeit in a variable way, to academic achievement in the subjects studied. This aspect is relevant insofar as it allows us to develop preventive interventions based on the executive training of these everyday skills.
Ukrainian–Russian bilingualism in the war-affected migrant and refugee communities in Austria and Germany: a survey-based study on language attitudes
Authors: Warditz Vladislava , Meir Natalia
Published: May 2024

Introduction

This paper provides an initial exploration of Ukrainian–Russian bilingualism in the context of the war-affected migration from Ukraine to Austria and Germany. While extensive research exists on various aspects of Ukrainian– Russian bilingualism in relation to Ukraine itself, thus far no studies have been conducted on this bilingualism in the diasporic context, i.e., as a language of the first and subsequential generations with a migrant background in Austria and Germany.

Methods

To address this research gap, our paper examines the language attitudes of two respondent groups with a Ukrainian background in the two countries: migrants and refugees who left Ukraine after 2014 and those who left after Russia’s invasion in February 2022. In the framework of a sociolinguistic survey, we describe their current attitudes regarding the use of Ukrainian and Russian, among others, in relation to the actual and intended use of the language(s) in the multilingual context of migration. The survey eliciting information on demographic information, language proficiency, language attitudes and language use was conducted on 406 Ukrainians in two host countries (Austria: n = 103; Germany: n = 306). First, we compared self-rated proficiency in Ukrainian and Russian as well as attitudes and use of these languages. Second, we applied a network modelling analysis to determine the nature of relationships between these variables.

Results and discussion

The results indicated that proficiency in Ukrainian and in Russian were the strongest nodes in the model affecting language use and language attitudes toward the respective languages. Our data analysis focused on the pragmatic and symbolic value of Russian and Ukrainian playing a crucial role in the language vitality in multilingual settings. The paper discusses the imbalanced correlation of the symbolic and pragmatic value of Ukrainian and Russian in the diasporic Ukrainian communities. While Ukrainian has gained a higher symbolic status, Russian maintains a better pragmatic one, despite its negative symbolic status. However, we anticipate that the increasing symbolic value of Ukrainian and the diminishing value of Russian will lead to an increase in the use of Ukrainian also in Russian-dominant bilingual groups of Ukrainian migrants and refugees, even as an insider-code in hermetic minority groups.
Impairment in acquisition of conditioned fear in people with depressive symptoms
Authors: Luo Rui-Han , Su Feng , Zhao Xin-Yue , Cao Tian-Hui , Liao Jing , Xue Yan-Xue , Huang Geng-Di , Yang Jian-Li
Published: May 2024

Background

Depression is one of the primary global public health issues, and there has been a dramatic increase in depression levels among young people over the past decade. The neuroplasticity theory of depression postulates that a malfunction in neural plasticity, which is responsible for learning, memory, and adaptive behavior, is the primary source of the disorder's clinical manifestations. Nevertheless, the impact of depression symptoms on associative learning remains underexplored.

Methods

We used the differential fear conditioning paradigm to investigate the effects of depressive symptoms on fear acquisition and extinction learning. Skin conductance response (SCR) is an objective evaluation indicator, and ratings of nervousness, likeability, and unconditioned stimuli (US) expectancy are subjective evaluation indicators. In addition, we used associability generated by a computational reinforcement learning model to characterize the skin conductance response.

Results

The findings indicate that individuals with depressive symptoms exhibited significant impairment in fear acquisition learning compared to those without depressive symptoms based on the results of the skin conductance response. Moreover, in the discrimination fear learning task, the skin conductance response was positively correlated with associability, as estimated by the hybrid model in the group without depressive symptoms. Additionally, the likeability rating scores improved post-extinction learning in the group without depressive symptoms, and no such increase was observed in the group with depressive symptoms.

Conclusion

The study highlights that individuals with pronounced depressive symptoms exhibit impaired fear acquisition and extinction learning, suggesting a possible deficit in associative learning. Employing the hybrid model to analyze the learning process offers a deeper insight into the associative learning processes of humans, thus allowing for improved comprehension and treatment of these mental health problems.
The effect of systematic couple group therapy on families with depressed juveniles: a pilot trial
Authors: Meng Tian-Jiao , Qian Ying , Wang Yu-Lu , Gao Bing-Ling , Liu Jia-Jia , Yue Jing-Li , Tang Deng-Hua
Published: May 2024

Background

Depression is a primary cause of illness and disability among teenagers, and the incidence of depression and the number of untreated young people have increased in recent years. Effective intervention for those youths could decrease the disease burden and suicide or self-harm risk during preadolescence and adolescence.

Objective

To verify the short efficacy of the systemic couple group therapy (SCGT) on youths’ depression changes and families with depressed adolescents.

Methods

The study was a self-control trial; only within-group changes were evaluated. Participants were couples with a depressed child who was resistant to psychotherapy; they were recruited non-randomly through convenient sampling. The paired-sample t-test and Wilcoxon signed-rank test were used to compare differences before and after interventions. The effect sizes were also estimated using Cohen’s d. Spearman’s correlation analysis was used to examine associations between changes.

Results

A downward trend was seen in depressive symptoms after treatment, and Cohen’s d was 0.33 (p = 0.258). The adolescents perceived fewer interparental conflicts, and the effect sizes were medium for perceived conflict frequency (0.66, p = 0.043), conflict intensity (0.73, p = 0.028), conflict solutions (0.75, p = 0.025), coping efficacy (0.68, p = 0.038), and perceived threat (0.57, p = 0.072). For parents, global communication quality, constructive communication patterns, and subjective marital satisfaction significantly improved after interventions, with large effect sizes (1.11, 0.85, and 1.03, respectively; all p < 0.001). Other destructive communication patterns such as demand/withdraw (p = 0.003) and mutual avoidance (p = 0.018) and communication strategies like verbal aggression (p = 0.012), stonewalling (p = 0.002), avoidance–capitulation (p = 0.036), and child involvement (p = 0.001) also reduced, with medium effect sizes (0.69, 0.52, 0.55, 0.71, 0.46, and 0.79, respectively). Meanwhile, the associations between depression changes and changes in interparental conflicts (p < 0.001) and marital satisfaction (p = 0.001) were significant.

Conclusions and clinical relevance

The SCGT offers the possibility for the treatment of families with depressed children who are unwilling to seek treatment. Helping parents improve communication and marital quality may have benefits on children’s depressive symptoms.
Spatial variation and predictors of incomplete pneumococcal conjugate vaccine (PCV) uptake among children aged 12–35 months in Ethiopia: spatial and multilevel analyses
Authors: Hailegebireal Aklilu Habte , Hailegebreal Samuel , Tirore Lire Lemma , Wolde Biruk Bogale
Published: May 2024

Background

Despite the Ethiopian government included the Pneumococcal Conjugate Vaccine (PCV) in the national expanded program for immunization in 2011, only 56% of children aged 12–23 months received the full dose of PCV. Despite some studies on PCV uptake in Ethiopia, there was a dearth of information on the geographical distribution and multilevel factors of incomplete PCV uptake. Hence, this study aimed to identify the spatial variations and predictors of incomplete PCV uptake among children aged 12–35 months in Ethiopia.

Methods

The study was based on an in-depth analysis of 2016 Ethiopia Demographic Health Survey data, using a weighted sample of 3,340 women having children aged 12–35 months. Arc-GIS version 10.7 and SaTScan version 9.6 statistical software were used for the spatial analysis. To explore spatial variation and locate spatial clusters of incomplete PCV, the Global Moran's I statistic and Bernoulli-based spatial scan (SaTScan) analysis were carried out, respectively. A multilevel mixed-effect multivariable logistic regression was done by STATA version 16. Adjusted odds ratio (AOR) with its corresponding 95% CI was used as a measure of association, and variables with a p < 0.05 were deemed as significant determinants of incomplete PCV.

Results

The overall prevalence of incomplete PCV in Ethiopia was found to be 54.0% (95% CI: 52.31, 55.69), with significant spatial variation across regions (Moran's I = 0.509, p < 0.001) and nine most likely significant SaTScan clusters. The vast majority of Somali, southeast Afar, and eastern Gambela regions were statistically significant hot spots for incomplete PCV. Lacking ANC visits (AOR = 2.76, 95% CI: 1.91, 4.00), not getting pre-birth Tetanus injections (AOR = 1.84, 95% CI: 1.29, 2.74), home birth (AOR = 1.72, 95% CI: 1.23, 2.34), not having a mobile phone (AOR = 1.64, 95% CI: 1.38, 1.93), and residing in a peripheral region (AOR = 4.63; 95% CI: 2.34, 9.15) were identified as statistically significant predictors of incomplete PCV.

Conclusion

The level of incomplete PCV uptake was found to be high in Ethiopia with a significant spatial variation across regions. Hence, the federal and regional governments should collaborate with NGOs to improve vaccination coverage and design strategies to trace those children with incomplete PCV in peripheral regions. Policymakers and maternal and child health program planners should work together to boost access to maternal health services like antenatal care and skilled delivery services to increase immunization coverage.
Kidney transplantation in Icelandic patients, 2000–2019: are outcomes affected by low volume?
Authors: Palsson Thordur P. , Andresdottir Margret B. , Jonsson Eirikur , Jonsson Johann , Hilmarsson Rafn , Indridason Olafur S. , Palsson Runolfur
Published: May 2024

Background

In Iceland, a small number of kidney transplants from living donors (LDs) are performed at Landspitali University Hospital (LUH) in Reykjavik, while deceased donor transplants have until recently invariably been carried out abroad. In this study, we evaluated the outcome of kidney transplantation in Icelandic patients.

Methods

This was a retrospective study that included all Icelandic residents who underwent kidney transplantation between 1 January 2000 and 31 December 2019. Data were obtained from the Icelandic End-Stage Kidney Disease Registry, medical records at LUH, and the Scandiatransplant database. The Chronic Kidney Disease Epidemiology Collaboration equation was used to calculate estimated glomerular filtration rate from serum creatinine for recipients and donors aged >18 years, and the modified Schwartz equation for those aged ≤18 years. Survival was estimated using the Kaplan–Meier method, and the log-rank test was employed for group comparisons.

Results

A total of 229 kidney transplants in 221 patients were performed during the 20-year period, of which 135 (58.9%) were from LDs. Transplants carried out at LUH were 118 (51.5%), of which 116 were from LDs. During a median follow-up of 7.4 years (range 0.1–20), 27 (12.2%) patients died, 20 (74%) of whom had a functioning graft. One-year patient survival was 99.1% [95% confidence interval (CI), 97.9–100], 5-year survival was 95.7% (95% CI, 92.7–98.7), and 10-year survival was 87.7% (95% CI, 82.4–93.4). Death-censored graft survival was 98.3% (95% CI, 96.6–100), 96.8% (95% CI, 94.4–99.2), and 89.2% (95% CI, 84.1–94.7) at 1, 5, and 10 years, respectively.

Conclusions

Patient and graft survival are comparable with those of large transplant centers, demonstrating the feasibility of running a quality kidney transplant program in a small nation in collaboration with a larger center abroad.
Investigating the dynamics of upland rice (Oryza sativa L.) in rainfed agroecosystems: an in-depth analysis of yield gap and strategic exploration for enhanced production
Authors: Santosa Yohanes Tri , Kurniasih Budiastuti , Alam Taufan , Handayani Suci , Supriyanta  , Ansari Andrianto , Taryono
Published: May 2024

Introduction

Addressing the global demand for rice production necessitates innovative approaches to enhance upland rice yield in rainfed agroecosystems, considering the challenges posed by increasing population, limited land fertility, low productivity, and water availability.

Methods

In this study, our study investigated the impact of biochar and organic fertilizer on ten promising rice lines (G1 – G10) and two control (G11 – G12) cultivars under rainfed conditions. The experimental design used a split-plot design with four soil amendments as main plots, namely control, organic fertilizer, biochar, and biochar + organic fertilizer and 12 rice genotypes as subplot.

Results

The absolute attainable yield gaps, differentiating organic and control (GAP1), biochar + organic and control (GAP2), and biochar and control (GAP3), ranged from 1.5 to 3.7 or increased of 91–580%, 0.8 to 3.5 (72–560%), and 0.6 to 2.58 tons/ha (58–472%), respectively. Notably, G2 + organic exhibited the highest positive absolute yield gap, ranging from 1.1 to 5.38 tons/ha, based on the yield gap matrix. Furthermore, genotype main effect plus genotype-environment interaction (GGE) biplot analysis identified G2 as the most promising rice line, displaying superior yield performance for cultivation in biochar and organic amended soils.

Discussion

These findings provide valuable insights for farmers, governments, and stakeholders, offering a roadmap to optimize rainfed areas for rice production, serving as practical guidance to enhance overall rice productivity in rainfed agroecosystems.
Advancing Livestock Technology: Intelligent Systemization for Enhanced Productivity, Welfare, and Sustainability
Authors: Vlaicu Petru Alexandru , Gras Mihail Alexandru , Untea Arabela Elena , Lefter Nicoleta Aurelia , Rotar Mircea Catalin
Published: May 2024

The livestock industry is undergoing significant transformation with the integration of intelligent technologies aimed at enhancing productivity, welfare, and sustainability. This review explores the latest advancements in intelligent systemization (IS), including real-time monitoring, machine learning (ML), and the Internet of Things (IoT), and their impacts on livestock farming. The aim of this study is to provide a comprehensive overview of how these technologies can address industry challenges by improving animal health, optimizing resource use, and promoting sustainable practices. The methods involve an extensive review of the current literature and case studies on intelligent monitoring, data analytics, automation in feeding and climate control, and renewable energy integration. The results indicate that IS enhances livestock well-being through real-time health monitoring and early disease detection, optimizes feeding efficiency, and reduces operational costs through automation. Furthermore, these technologies contribute to environmental sustainability by minimizing waste and reducing the ecological footprint of livestock farming. This study highlights the transformative potential of intelligent technologies in creating a more efficient, humane, and sustainable livestock industry.
Transcultural Appropriation and Aesthetic Breakthrough of Hollywood Film Noir in Contemporary Taiwan Suspense Thriller Films: A Case Study of Who Killed Cock Robin (2017)
Authors: Zhu Xinchen
Published: May 2024

The production of suspense thriller films has recently surged in Taiwan. These films adopt narrative techniques and visual aesthetics reminiscent of classic and neo-noir Hollywood cinema but also address social issues in Taiwan and represent transcultural aesthetic appropriation of film noir. This article employs a case study approach to examine the narrative and visual style of the Taiwanese suspense thriller Who Killed Cock Robin (2017), using film narratology as a textual analytical framework. This study considers themes, characters, visual style, and narrative structures, focusing on fundamental characteristics of classic film noir and neo-noir. This study reveals that the selected film both appropriates and deviates from the aesthetics of Hollywood film noir. It effectively incorporates aesthetic elements from classic Hollywood film noir and neo-noir, enriching the intricacies of storytelling and character depiction, while also localizing them through complex narrative strategies and nuanced Taiwanese cultural and social elements. The film brings attention to several prevalent issues in Taiwan’s media landscape, including truth manipulation, sensationalism, tabloidization, and conglomerate and political control. The film portrays Yi-Chi as a morally compromised character embodying the detective archetype with classic noir traits, while also reflecting the “Eastern mentality” in Taiwan journalism. Despite his moral compromises, Yi-Chi partly retains traditional virtues, presenting a nuanced view of human nature that blends pessimism and optimism in Taiwan. This approach creates a distinct cross-cultural narrative that resonates emotionally with Taiwanese audiences, while also contributing to the broader global cinematic discourse on film noir.
Evaluating Frequency Domain Reflectometry as a Tool for Lithium-Ion Battery Health Prognosis
Authors: Asiedu-Asante Ama Baduba , Pickert Volker , Mamlouk Mohamed , Tsimenidis Charalampos
Published: May 2024

Monitoring battery aging is crucial for maintaining reliability and performance. This study investigates Frequency Domain Reflectometry (FDR) as a tool for monitoring lithium-ion battery State-of-Health (SoH). While FDR has been applied in battery research, the existing literature fails to address SoH assessment and lacks studies on larger battery samples to provide more meaningful results. In this work, nineteen cells initially underwent Electrochemical Impedance Spectroscopy (EIS) to assess their degradation levels during cyclic aging. This work evaluates FDR’s effectiveness in monitoring battery health indicators, such as capacity and equivalent series resistance (ESR), by correlating these with FDR-measured impedance between 300 kHz and 1 GHz. Analytical comparison between impedance measured before and after de-embedding processes were presented. The results show FDR reactance within 300 kHz–40 MHz correlates with EIS-measured ESR, suggesting its potential as a SoH indicator. However, reduced sensitivity and accuracy, particularly after de-embedding, may limit practical applicability. Additionally, resonance-based analysis was conducted to explore the relationship between changes in circuit resonance and cell dielectric permittivity. Despite having the lowest sensitivity, the method showed that the resonance frequencies of cells remain relatively constant, mirroring behaviours associated with changes in resistive properties. Overall, this study provides insights into FDR’s potential for battery diagnostics while highlighting avenues for future research to enhance effectiveness in real-world scenarios.
A Bibliometric Analysis on Research Progress of Earthworms in Soil Ecosystems
Authors: Chen Jiayi , Chen Shufang , Liu Ziqiang , Wu Lizhu , Xiang Huimin , Zhang Jiaen , Wei Hui
Published: May 2024

The earthworm, as a soil engineer, plays highly important roles in the soil ecosystem for shaping soil structure, promoting soil fertility, regulating microbial community composition and activities and decomposing soil pollutants. However, the research progresses on this important soil fauna have rarely been reviewed so far. Therefore, we conducted a bibliometric analysis of the literature published during 1900–2022, which was collected from the Web of Science Core Collection (WoS). The results showed that three periods (1900–1990, 1991–2005 and 2006–2022) could be identified in terms of the intensity of publications on the topic, and the number of publications kept increasing since 2006. The United States produced the highest publication record at the country scale, whereas Chinese Academy of Sciences was the most productive institution. Chinese institutions and authors played an active and prominent role during 2018–2022. Soil Biology & Biochemistry was the most popular journal for the topic-related research. In these publications, Professor Lavelle P was the most influential author. Based on a citation network of the top 50 cited papers, four hotspots were identified, i.e., the ecological effects of earthworms, the impact of agricultural activities on earthworms, earthworm ecotoxicology and earthworm invasion. Moreover, “impact”, “biodiversity”, “oxidative stress”, “diversity”, “response”, “Eisenia fetida” and “exposure” were the emerging and active topics in recent years. This study can help us to better understand the relevant subject categories, journals, countries, institutions, authors and articles and identify the research hotspots and emerging trends in the field of soil earthworm research.
Drug Repurposing: Exploring Potential Anti-Cancer Strategies by Targeting Cancer Signalling Pathways
Authors: Haddad Natalia , Gamaethige Sara Magura , Wehida Nadine , Elbediwy Ahmed
Published: May 2024

The repurposing of previously clinically approved drugs as an alternative therapeutic approach to treating disease has gained significant attention in recent years. A multitude of studies have demonstrated various and successful therapeutic interventions with these drugs in a wide range of neoplastic diseases, including multiple myeloma, leukaemia, glioblastoma, and colon cancer. Drug repurposing has been widely encouraged due to the known efficacy, safety, and convenience of already established drugs, allowing the bypass of the long and difficult road of lead optimization and drug development. Repurposing drugs in cancer therapy is an exciting prospect due to the ability of these drugs to successfully target cancer-associated genes, often dysregulated in oncogenic signalling pathways, amongst which are the classical cancer signalling pathways; WNT (wingless-related integration type) and Hippo signalling. These pathways play a fundamental role in controlling organ size, tissue homeostasis, cell proliferation, and apoptosis, all hallmarks of cancer initiation and progression. Prolonged dysregulation of these pathways has been found to promote uncontrolled cellular growth and malignant transformation, contributing to carcinogenesis and ultimately leading to malignancy. However, the translation of cancer signalling pathways and potential targeted therapies in cancer treatment faces ongoing challenges due to the pleiotropic nature of cancer cells, contributing to resistance and an increased rate of incomplete remission in patients. This review provides analyses of a range of potential anti-cancer compounds in drug repurposing. It unravels the current understanding of the molecular rationale for repurposing these drugs and their potential for targeting key oncogenic signalling pathways.
Lysophosphatidic Acid Stimulates Mitogenic Activity and Signaling in Human Neuroblastoma Cells through a Crosstalk with Anaplastic Lymphoma Kinase
Authors: Dedoni Simona , Olianas Maria C. , Onali Pierluigi
Published: May 2024

Lysophosphatidic acid (LPA) is a well-documented pro-oncogenic factor in different cancers, but relatively little is known on its biological activity in neuroblastoma. The LPA effects and the participation of the tyrosine kinase receptor anaplastic lymphoma kinase (ALK) in LPA mitogenic signaling were studied in human neuroblastoma cell lines. We used light microscopy and [3H]-thymidine incorporation to determine cell proliferation, Western blot to study intracellular signaling, and pharmacological and molecular tools to examine the role of ALK. We found that LPA stimulated the growth of human neuroblastoma cells, as indicated by the enhanced cell number, clonogenic activity, and DNA synthesis. These effects were curtailed by the selective ALK inhibitors NPV-TAE684 and alectinib. In a panel of human neuroblastoma cell lines harboring different ALK genomic status, the ALK inhibitors suppressed LPA-induced phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2), which are major regulators of cell proliferation. ALK depletion by siRNA treatment attenuated LPA-induced ERK1/2 activation. LPA enhanced ALK phosphorylation and potentiated ALK activation by the ALK ligand FAM150B. LPA enhanced the inhibitory phosphorylation of the tumor suppressor FoxO3a, and this response was impaired by the ALK inhibitors. These results indicate that LPA stimulates mitogenesis of human neuroblastoma cells through a crosstalk with ALK.
Mathematical Models of the Arabidopsis Circadian Oscillator
Authors: Henao Lucas , Ares Saúl , Catalán Pablo
Published: May 2024

We review the construction and evolution of mathematical models of the Arabidopsis circadian clock, structuring the discussion into two distinct historical phases of modeling strategies: extension and reduction. The extension phase explores the bottom-up assembly of regulatory networks, introducing as many components and interactions as possible to capture the oscillatory nature of the clock. The reduction phase deals with functional decomposition, distilling complex models to their essential dynamical repertoire. Current challenges in this field, including the integration of spatial considerations and environmental influences like light and temperature, are also discussed. The review emphasizes the ongoing need for models that balance molecular detail with practical simplicity.
Improving the Transparency of a MgAl2O4 Spinel Damaged by Sandblasting through a SiO2-ZrO2 Coating
Authors: Zegadi Akram , Ayadi Abdelwahhab , Khellaf Ikram , Hamidouche Mohamed , Fantozzi Gilbert , Durán Alicia , Castro Yolanda
Published: May 2024

Transparent materials in contact with harmful environments such as sandstorms are exposed to surface damage. Transparent MgAl2O4 spinel used as protective window, lens or laser exit port, among others, is one of the materials affected by natural aggressions. The impact of sand particles can cause significant defects on the exposed surface, thus affecting its optical and mechanical behavior. The aim of this work is to improve the surface state of a spinel damaged surface by the deposition of a thin layer of SiO2-ZrO2. For this purpose, spinel samples obtained from different commercial powders sintered by Spark Plasma Sintering were sandblasted and further coated with a SiO2-ZrO2 thin layer. The coating was successfully synthesized by the sol/gel method, deposited on the sandblasted samples and then treated at 900 °C, reaching a final thickness of 250 nm. The results indicated that sandblasting significantly affects the surface of the spinel samples as well as the optical transmission, confirmed by UV-visible spectroscopy and profilometry tests. However, the deposition of a SiO2-ZrO2 coating modifies the UV-visible response. Thus, the optical transmission of the S25CRX12 sample presents the best transmission values of 81%, followed by the S25CRX14 sample then the S30CR sample at 550 nm wavelength. An important difference was observed between sandblasted samples and coated samples at low and high wavelengths. At low wavelengths (around 200 nm), sandblasting tends to improve significantly the transmission of spinel samples, which exhibit a low transmission in the pristine state. This phenomenon can be attributed to the healing of small superficial defects responsible for the degradation of transmission such as pores or flaws. When the initial transmission at 200 nm is high, the sandblasting worsens the transmission. Sandblasting reduces slightly the transmission values for long wavelengths due to the formation of large superficial defects like chipping by creation and propagation of lateral cracks. The coating of the sandblasted samples exhibits some healing of defects induced by sandblasting. The deposition of the SiO2-ZrO2 layer induces a clear increase in the optical transmission values, sometimes exceeding the initial values of the transmission in the pristine state.
Assessment of Childhood Stunting Prevalence over Time and Risk Factors of Stunting in the Healthy Village Programme Areas in Bangladesh
Authors: Sin May Phyu , Forsberg Birger C. , Peterson Stefan Swartling , Alfvén Tobias
Published: May 2024

Childhood stunting is a significant public health concern in Bangladesh. This study analysed the data from the Healthy Village programme, which aims to address childhood stunting in southern coastal Bangladesh. The aim was to assess childhood stunting prevalence over time and explore the risk factors in the programme areas. A cross-sectional, secondary data analysis was conducted for point-prevalence estimates of stunting from 2018 to 2021, including 132,038 anthropometric measurements of under-five children. Multivariate logistic regression analyses were conducted for risk factor analysis (n = 20,174). Stunting prevalence decreased from 51% in 2018 to 25% in 2021. The risk of stunting increased in hardcore poor (aOR: 1.46, 95% CI: 1.27, 1.68) and poor (aOR: 1.50, 95% CI: 1.33, 1.70) versus rich households, children with mothers who were illiterate (aOR: 1.25, 95% CI: 1.09, 1.44) and could read and write (aOR: 1.35, 95% CI: 1.16, 1.56) versus mothers with higher education, and children aged 1–2 years compared with children under one year (aOR: 1.32, 95% CI: 1.20, 1.45). The stunting rate was halved over three years in programme areas, which is faster than the national trend. We recommend addressing socioeconomic inequalities when tackling stunting and providing targeted interventions to mothers during the early weaning period.
Correction: Gonçalves et al. Antimicrobial Activity of Bovine Bone Scaffolds Impregnated with Silver Nanoparticles on New Delhi Metallo-β-Lactamase-Producing Gram-Negative Bacilli Biofilms. Compounds 2023, 3, 584–595
Authors: Gonçalves Geiziane Aparecida , Ribeiro Victoria Stadler Tasca , Dantas Leticia Ramos , de Andrade Ana Paula , Suss Paula Hansen , Witt Maria Alice , Tuon Felipe Francisco
Published: May 2024

The author would like to make the following corrections to the original publication [...]
Design of a Sigma-Delta Analog-to-Digital Converter Cascade Decimation Filter
Authors: Ye Mao , Liu Zitong , Zhao Yiqiang
Published: May 2024

As the current mainstream high-precision ADC architecture, sigma-delta ADC is extensively employed in a wide range of domains and applications. This paper presents the design of a highly efficient cascaded digital decimation filter for sigma-delta ADCs, emphasizing the suppression of high folding band noise and the achievement of a flat passband. Additionally, this study addresses the critical balance between filter performance and power consumption. An inserting zero (IZ) filter is incorporated into a cascaded integrator comb (CIC) filter to enhance aliasing suppression. The IZ filter and compensation filter are optimized using the particle swarm optimization (PSO) algorithm to achieve greater noise attenuation and smaller passband ripple. The designed filter achieves a noise attenuation of 93.4 dB in the folding band and exhibits an overall passband ripple of 0.0477 dB within a bandwidth of 20 KHz. To decrease the power consumption in the filter design, polyphase decomposition has been applied. The filter structure is implemented on an FPGA, processing a 5-bit stream from a 64-times oversampling rate and third-order sigma-delta modulator. The signal-to-noise ratio (SNR) of the output signal reaches 91.7 dB. For ASIC design, the filter utilizes 180 nm CMOS technology with a power consumption of 0.217 mW and occupies a layout area of 0.72 mm2. The post-layout simulation result indicates that the SNR remains at 91.7 dB.
Examination of Operational Methods for a Low-Temperature Aquifer Thermal Storage Air Conditioning System Based on Operational Performance and Considerations of Thermal Storage and Pumping Volume Balance
Authors: Cui Linri , Nishioka Masatoshi , Nakao Masaki , Ueda Kenji
Published: May 2024

Aquifer Thermal Energy Storage (ATES) systems are garnering attention as high-efficiency air conditioning technologies that contribute to the realization of a carbon-neutral society. This study focuses on an ATES system constructed in Japan, characterized by its complex geological conditions and thin aquifer layers. Detailed actual performance data measured over four years are presented, and performance analysis results show that a COP of 5 was achieved for the overall building cooling and heating system. In addition, the study provides a detailed analysis of the imbalance in heat quantity, remaining heat storage, and other factors based on actual data, identifying operational issues and summarizing specific improvement measures. Finally, as a proposal for a sustainable operational method to balance the cumulative heat storage and pumping volume of cold and hot water, specific operational procedures are summarized, including setting the return water temperature for the next season based on the dimensionless average pumping temperature of the previous season, and a flowchart is presented. There is no prior research that shows such specific operational procedures, and this can be considered an important achievement of this study.