bluuebunny/crossref_metadata_2025 huggingface dataset:
Global barriers to provision and utilization of mental health services: a systematic scope study
Authors: Sarikhani Yaser , Bastani Peivand , Karajizadeh Mehrdad , Kavosi Zahra , Ravangard Ramin
Published: September 2019

Background Mental Health (MH) is an important part of community well-being and a remarkable portion of global burden of diseases is related to mental disorders. Despite this fact, little attention has been given to the provision of adequate and appropriate MH services and improving equitable access to these services in some parts of the world. This review was aimed to identify main global barriers to provision and utilization of MH services.Methods We carried out a systematic and comprehensive search on 7 important online databases for English-language literature on global barriers to provision and utilization of MH services applying Arksey and O’Malley guideline. The extracted materials were tabulated and synthesized using a content analysis approach.Results Three main themes were developed regarding the barriers to provision of MH services including resource and administrative barriers, information and knowledge barriers, as well as policy and legislation barriers. Five frequent barriers to utilization of MH services were attitudinal barriers, structural barriers, knowledge barriers, treatment-related barriers, and family-related barriers as well.Conclusions It is suggested that, improvement of public knowledge regarding MH, reallocation of health resources toward high-priority MH needs, developing community-based insurance, as well as integration of MH services into all levels of health-care systems and MH policy into general health policy could be considered as effective strategies to tackling the challenges especially in low- and middle-income countries. Further study is also needed for determining relative importance of the barriers and the related solutions in this regard.
Establishing A Sorting Protocol for The Data Cleaning of Health Record Databases for Eco-Epidemiological Studies: The Case of Beirut
Authors: Ghabi Elie , Farah Wehbeh , Abboud Maher , Chalhoub Elias , Ziade Nelly , Annesi-Maesano Isabella , Habib Laurie Abi , Mrad Myriam
Published: September 2019

Background Health information records in many countries, especially developing countries, still rely on a paper-based system which, when compared to electronic systems, are disadvantageous in terms of storage and data extraction. Given the importance of health records as a data resource for epidemiological studies, guidelines for systematic data cleaning and sorting are essential, yet are largely absent in the literature. This paper discusses the process by which an electronic database was generated from emergency department registers in Lebanon and the data subsequently cleaned, sorted, and categorized.Methods Demographic and health complaint-related information was extracted from emergency department registers of a convenience sample of seven hospitals in Beirut. Appropriate categories were selected for data categorization. For health-complaint related information, disease categories and codes were selected according to the International Classification of Disease 10th Edition.Results A total of 16,537 entries were collected. Demographic information was categorized into appropriate categories and groups as required for future epidemiological studies. Analysis of the health information allowed for the creation of a sorting algorithm which then used to categorize and code the heath data. Several counts were then performed to represent and visualize the data numerically and graphically to aid in data interpretation.Conclusions The article describes the current state of health information records in Lebanon and the associated disadvantages of a paper-based system in terms of storage and data extraction and subsequent analysis. Furthermore, the article describes the algorithm by which health information was sorted and categorized to allow for future data analysis using paper records.
Independent Risk Factor Analysis for Major Cardiovascular Adverse Events in Patients with Mild Coronary Stenosis
Authors: Luo Wei , Zhao Ru , Song YanQiu , Zhao Hui , Ma WeiJun , Ma YanZhe , Cong Hongliang
Published: September 2019

Background: Independent risk factors for major adverse cardiovascular event (MACE) in patients with mild coronary stenosis are uncertain. This study aims to predict high-risk plaques detected by coronary computed tomographic angiography (CCTA) associated with indicative biomarkers.Methods: Totally 381 patients with mild coronary stenosis were included and MACE incidences were recorded through a 24-month follow-up. Totally 91 high-risk plaques are detected by CCTA, dividing into three plaque groups: high-risk group (HR), intermediate-risk group (IR) and low-risk group (LR). Specific blood biomarker measurements of hs-CRP, MMP-9, and MPO were taken simultaneously.Results: The mean age, levels of hs-CRP and MPO in HR and IR group were significantly higher than LR group. A considerably higher level of MMP-9 showed in HR group compared to LR group. The incidence rates of MACE were remarkably higher in HR group than LR group and IR group. Kaplan—Meier survival analysis demonstrated that the cumulative event—free survival rate of HR was significantly higher than that in LR and IR group and there were no significant difference between LR and IR group. The univariate COX regression analysis indicated that the age of patients, hs-CRP, MPO, and high-risk plaque scores≥2 were independent risk factors for MACE. Conclusion: Age, levels of hs-CRP and MPO, and high-risk plaque features informed by CCTA independently predicted MACE in patients with mild coronary stenosis. These results may improve the risk stratification in patients with mild coronary stenosis and suggest strategies for the individualized prevention programs.
Second drug-eluting stent implantation versus coronary artery bypass grafting in treatment of young patients with left main and/or multivessel coronary disease
Authors: Chen Xue , Zhang Xuehui , Yan Yunfeng , Zhao Xin , Nie Maoxiao , Feng Tingting , Liang Zhe , Zhao Quanming
Published: September 2019

Background Many studies have compared outcomes of coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) for complex coronary artery disease (CAD). However, no trials have focused on young patients (< 45 years) with complex CAD. We conducted a retrospective evaluation to compare the outcomes of a 2nd drug-eluting stent and CABG in young patients with LM or three-vessel disease. Methods and results In the young patients with complex CAD who underwent PCI or CABG, Kaplan-Meier analysis and Cox regression before and after propensity-score matching were used to compare major adverse cardiac and cerebrovascular events (MACCE), including myocardial infarction (MI), stoke, death and repeat revascularization. During the follow-up, MACCE occurred in 20.5% of patients in the PCI group and 8.6% in the CABG group (hazard ratio [HR]: 3.263, 95% confidence interval [CI]: 1.379 to 7.722, p=0.007). Repeat revascularization occurred more frequently in the PCI group (18.9% vs. 3.7% respectively, HR: 6.968, 95% CI: 2.036 to 23.842, p=0.002). There were no significant differences in other endpoints. After propensity-score matching, no conclusions were changed. Conclusions In young patients with LM or three-vessel disease, PCI showed a higher incidence of MACCE, which was mainly driven by repeat revascularization. However that did not translate into hard endpoints differences. Therefore, PCI is an alternative treatment to CABG in young patients with complex CAD.
Platelet P-selectin(CD62P) and soluble TREM-like transcript-1(sTLT-1) are associated with coronary artery disease-A case control study
Authors: Shen Li , Yang Tianlun , Xia Ke , Yan Zhiqiang , Tan Juanjuan , Li Lei , Qin Yingchun
Published: September 2019

Background/Aims: Platelet activation plays a crucial role in the pathogenesis of coronary artery disease(CAD) ， platelet P-selectin(CD62P )is a platelet classic activation indicator in platelet surface and soluble TREM-like transcript-1 (sTLT-1) is a new one,the relation between these two makers and acute coronary syndromes(ACS) has not been elucidated. This study aimed to investigate the expression of CD62P in platelet surface and sTLT-1 on serum and their relationship with CAD. Methods: We measured the levels of CD62P and sTLT-1 in 83 patients undergoing CAD compared to 49 controls.The associations with age, blood pressure,lipid profiles, body mass index and liver injury marker levels were also examined. Results: A stepwise increase in CD62P concentration was found based on the number of CAD patients (P <0.01), especially in AMI (P <0.01) . Serum sTLT-1 concentration of AMI and UAP were more higher than the NC group (P <0.01). Conclusions: The consistent of sTLT-1 and CD62P expression levels in CAD,indicating that sTLT-1 level may be a new maker of platelet activating and positively related with CAD.
Low Bone Mineral Density Could Predict Cognitive Impairment during the Acute and Recovery Phases of Ischemic Stroke
Authors: Lee Sang-Hwa , Jang Min Uk , Kim Yerim , Park So Young , Kim Chulho , Kim Yeo Jin , Sohn Jong-Hee
Published: September 2019

Background: Little is known about the effect of osteoporosis at the acute and recovery phase of stroke on cognitive function. We evaluated the effect of osteoporosis on cognitive function in patients with ischemic stroke aged >50 years.Methods: We retrospectively examined consecutive patients with acute stroke hospitalized between 2016 and 2018. Osteoporosis was defined as a T score of <-2.5 for the femoral neck or lumbar spine bone mineral density. The primary outcome was cognitive impairment measured by the Korean Mini-Mental State Examination in the acute phase and recovery phase of ischemic stroke. The association between osteoporosis and the severity of cognitive impairment was investigated using a multivariate analysis.Results: Of the 260 included subjects (107 men and 153 women), 70 (26.9%) had osteoporosis. Cognitive impairment was more severe in the osteoporosis group than in the non-osteoporosis group (30.5% versus 47.1%, p=0.001). After recovery phase of stroke, the proportion of patients with cognitive impairment remained higher in the osteoporosis group. The multivariate analysis revealed a correlation between a low femoral neck bone mineral density and severe cognitive impairment in the acute and recovery phases of stroke (adjusted odds ratio [OR] 3.66, 95% confidence interval [CI] 1.05-12.79 in the acute phase and adjusted OR 11.17, 95% CI 1.12-110.98 in the recovery phase), whereas lumbar spine osteoporosis was not associated with cognitive impairment.Conclusions: Low bone mineral density is associated with poor cognitive function in patients with acute stroke. Early bone mineral density assessments during acute stroke, particularly at the femoral neck, may be a useful marker of cognitive function.
Unintentional Exposure and Incidental Findings during Conventional Chest Radiography in the Pediatric Intensive Care Unit
Authors: Temsah Mohamad-Hani , Al-Eyadhy Ayman , Alsohime Fahad , Nassar Saeed Majed , AlHoshan Talal Nabil , Alebdi Hatim Abdullah , Almojel Faisal , AlBattah Muath Abdullah , Narayan Omendra , Hasan Gamal Mohamad , Abujamea Abdullah
Published: September 2019

Background: Anatomical overexposure is common in CXRs of pediatric patients. However, overexposure may reveal incidental findings that can help to guide patient management or warrant quality improvement. Objective: To assess the prevalence of overexposure in chest X-ray (CXRs) in pediatric intensive care unit (PICU); and identify the incidental findings within overexposed areas. Materials and methods: Retrospective cohort study of children admitted to PICU. Two independent evaluators reviewed patient’s charts and digital CXRs according to the American College of Radiology standards; to evaluate overexposure of the anatomical parameters and incidental findings. Results: A total of 400 CXRs of 85 patients were reviewed. The mean number of CXRs per patient was 4.7. Almost all (99.75%) CXRs met the criteria for overexposure, with the most common being upper abdomen (99.2%), upper limbs (97%) and neck (95.7%). In addition, 43% of these X-rays were cropped by the radiology technician to appear within the requested perimeter. There was a significant association between field cropping and overexposure (t-test: t=9.8, p<.001). Incidental findings were seen in 41.5% of the radiographs; with the most common being gaseous abdominal distension (73.1%), low-positioned nasogastric tube (24.6%), and constipation (10.3%). Conclusions: Anatomical overexposure in routine CXRs remains high and raises a concern in PICU practice. Appropriate collimation of the X-ray beam, rather than electronically cropping the image, is highly recommended to minimize hiding incidental findings in the cropped-out areas. Redefining the anatomic boundaries of CXR in critically ill infants and children may need further studies and consideration. Quality improvement initiatives to minimize radiation overexposure in PICU are recommended.
Utilization and economic burden of Percutaneous Vertebroplasty or Percutaneous Kyphoplasty for Treatment of Osteoporotic Vertebral Compression Fractures in China: A Retrospective Claim Database Study
Authors: Yang Dehong , Zhang Yanlei , Ma Xiao , Huo Li , Li Liran , Gao Yue , Xuan Jianwei
Published: September 2019

Background Osteoporotic vertebral compression fractures (OVCF) is a common and often debilitating complication of osteoporosis, leading to significant morbidity and increased mortality. Percutaneous vertebroplasty (PVP) and Percutaneous kyphoplasty (PKP) are recommendable surgical treatments for osteoporotic vertebral compression fractures.Objective To evaluate PVP/PKP utilization and their related costs for OVCF treatment in China.Methods A population-based medical claims database of a metropolitan city in China was analyzed, which included all inpatient claims from 01/01/2015 to 31/12/2017. Eligible patients were 50 years or older, diagnosed with vertebral fractures with/without osteoporosis, and received PVP/PKP. Survival analysis function was used to estimate time to re-surgery and non-parametric statistical tests were used for comparison of cost and re-surgery rate between PVP and PKP.Results Of the 50,686 patients with OVCF identified, 14,527 (28.66%) received a total number of 15,599 records of PVP/PKP surgeries from 2015 to 2017. Mean age was 75 at the first surgery captured in the database analysis period; and females accounted for 79.54% of all cases. Median length of surgery stay was 9 days. Cumulative re-surgery rates were 1.22% in 30 days, 2.58% in 90 days, 3.61% in 183 days, 5.42% in one year, and 7.95% in two years. There was no significant difference of re-surgery rate between PVP and PKP (p=0.3897). Median time to the re-surgery was 139 days. Mean cost per PVP/PKP-related hospitalization was 35,906 CNY (34,195 CNY for PVP, 44,414 CNY for PKP, p<0.01). The overall cost of hospitalization averaged 186.61 million CNY (26.97 million USD) per year in this metropolitan city.Conclusion From 2015 to 2017, nearly one third of OVCF inpatients received PVP/PKP and re-surgery rate was high. PKP/PVP procedures for OVCF place a high economic burden for both the healthcare system and patients. Early detection and treatment of patients with osteoporosis is critical in China.
Human papillomavirus type 18 oncoproteins exert their oncogenicity in esophageal and tongue squamous cell carcinoma cell lines distinctly
Authors: Boon Siaw Shi , Chen Zigui , Ching Karen Lee Yin , Cai Liuyang , Li Jintao , Zhong Rugang , Chan Paul Kay Sheung
Published: September 2019

Background: Increasing evidence indicates an etiological role of human papillomavirus (HPV) in head and neck cancers, particularly oropharyngeal squamous cell carcinoma (OPSCC). However, the association between HPV and other cancers, including esophageal and tongue remains unclear.
Methods: We compared the molecular characteristics of HPV18 E6 and E7 in esophageal (EC109 and EC9706) and tongue (Tca83) cancer cell lines with reference to cervical cancer (HeLa). We studied the expression of HPV transcripts using Next Generation RNA sequencing. We used small interference RNA (siRNA) against HPV18 oncoproteins to verify their oncogenic roles in molecular signaling, targeting metalloproteases and apoptotic pathways in these cancers.
Results: We observed that the HPV transcription profiles of esophageal and tongue cancer cells mimicked that of cervical cancer cells, with notable disruption of E2, and expression of E6, spliced E6 (E6 * ), E7, E1 and L1 transcripts. As with cervical cancer cells, p53 and its downstream transactivation target, p21, were found to be the major targets of E6 in esophageal and tongue cancer cell lines. Intriguingly, E7 preferentially targeted p130 in the two esophageal cancer cell lines, instead of pRb as in cervical cancer. Tca83 exhibited an E7 to E6 transcript ratio comparable to HeLa (cervix), targeted the ERK1/2 and MMP2 pathways, and was dependent on E6 and E7 to survive and proliferate. In contrast, both the esophageal cancer cell lines were distinct from HeLa in these aspects.
Conclusion: This is the first study to delineate the transcripts expression and role of HPV18 E6 and E7 in esophageal and tongue cancer cell lines. This findings suggest that HPV18 plays an oncogenic role in inducing these cancers, albeit via distinct pathways than those observed in cervical cancer.
Implementation of Gamification from blended learning based on the flex model and efficacy of this program on students: an experiences from Iran, An Quasi-experimentaL Study
Authors: abdian tahereh , abdollahifar saeed , Mosalanejad Leili
Published: September 2019

Background: New gamification technology with a detailed understanding of the goals and prospects, and with the help of game elements and techniques, leads to promotion of motivation and participation, and ultimately behavior change.
Methods: In this study, with the design of mental illness lessons for undergraduate and executive groups, using flex model, two parts of technical and educational design were used. In the technical section, three parts on dynamics, mechanisms and elements of gaming were considered. Intervention was studied on different groups of medical students including medical, health, and laboratory sciences and its impact on learning and performance was studied using quantitative and qualitative analyses.
Results: The results of the students’ prospective about the efficacy of the method showed that the mean scores of most of the items were higher than the average. This implies that students’ attitude towards using gamification was positive. In the other part, the qualitative results of the study were analyzed and the student's analysis of their advantages and disadvantages and their perceptions on the impact of the intervention were examined.
Conclusion: Based on the Flex model, mental gamification based on blended learning is effective in shaping the students' satisfaction.
Comparative transcriptome analysis of two different genotypes of wheat (Triticum aestivum L.) in response to spring freeze-stress
Authors: Zhang Ziyang , Wang Zhiwei , Wang Zhiyu , Zhu Qidi , Liu Mingjiu
Published: September 2019

The authors have requested that this preprint be removed from Research Square.
Comparative study between intrathecal dexmedetomidine and intrathecal magnesium sulfate for the prevention of post-spinal anaesthesia shivering in uroscopic surgery. (RCT)
Authors: Omar Heba , adel Wessam , Hassan Mohamed Mahmoud , Hassan Amany , Hassan Passaint , Elshall Ahmed , Khalid Dalia , Mostafa Maha , Zarif pierre , hossameldin Mona , Wedad Mai , abdelhamid Bassant Mohamed
Published: September 2019

Background: Hypothermia and shivering are common complications after spinal anaesthesia, especially after uroscopic procedures in which large amounts of cold intraluminal irrigation fluids are used. Magnesium sulfate and dexmedetomidine are the most effective adjuvants with the least side effects. The aim of this study was to compare the effects of intrathecal dexmedetomidine versus intrathecal magnesium sulfate on the prevention of post-spinal anaesthesia shivering.
Methods: This prospective randomized, double-blinded controlled study included 105 patients who were scheduled for uroscopic surgery at the Kasr El-Aini Hospital. The patients were randomly allocated into three groups. Group C (n=35) received 2.5 ml of hyperbaric bupivacaine 0.5% (12.5 mg) + 0.5 ml of normal saline, Group M (n=35) received 2.5 ml of hyperbaric bupivacaine 0.5% (12.5 mg) + 25 mg of magnesium sulfate in 0.5 ml saline, and Group D (n=35) received 2.5 ml of hyperbaric bupivacaine 0.5% (12.5 mg) + 5 μg of dexmedetomidine in 0.5 ml saline. The primary outcomes were the incidence and intensity of shivering. The secondary outcomes were the incidence of hypothermia, sedation, the use of meperidine to control shivering and complications.
Results: Group C had significantly higher proportions of patients who developed shivering (21), developed grade IV shivering (20) and required meperidine (21) to treat shivering than group M (8,5,5) and group D (5,3,6) , which were comparable to each other.
The time between block administration and meperidine administration was similar among the three groups. Hypothermia did not occur in any of the patients.
The three groups were comparable regarding the occurrence of nausea, vomiting, bradycardia and hypotension. All the patients in group C, 32 patients in group M and 33 patients in group D had a sedation score of 2. Three patients in group M and 2 patients in group D had a sedation score of 3.
Conclusions: Intrathecal injections of both dexmedetomidine and magnesium sulfate were effective in reducing the incidence of post -spinal anaesthesia shivering. Therefore, we encourage the use of magnesium sulfate, as it is more physiologically available, more readily available in most operating theatres and much less expensive than dexmedetomidine.
Seedling Emergence and Seedling Growth of Mustard and Rapeseed Genotypes under Salt Stress
Authors: Hooks Triston , Niu Genhua , Ganjegunte Girisha
Published: September 2019

Core Ideas

Varietal differences in salt tolerance were observed.

There were differences in salt tolerance between the seedling emergence and seedling growth stages.

Growth and photosynthesis decreased at high salinity, indicating osmotic stress.

Chlorophyll fluorescence did not decrease at high salinity, indicating no stress on photosystem II.

Leaf chloride concentrations varied among genotypes, suggesting different salt tolerance mechanisms.

Salt‐tolerant energy crops can be grown on marginal lands for sustainable biofuel production without competing with food crops for arable land. However, salt tolerance is a variable trait among plant species, varieties, and growth stages. In this study, the relative salt tolerance of seven mustard (Brassica juncea) genotypes and four rapeseed (Brassica napus) genotypes was evaluated at the seedling emergence and seedling growth stages. In the first experiment, seeds were sown in a growth chamber with reverse osmosis water or saline solution at an electrical conductivity (EC) of 10 mS cm−1 for 10 d, and emergence was determined daily. In the second experiment, seedlings were grown in a greenhouse and irrigated with nutrient solution (control) with an EC of 1.5 mS cm−1 or saline solutions (EC 5 and 10 mS cm−1, respectively) for 4 wk. For the seedling emergence stage, the relative emergence percent, and emergence index showed great variation among genotypes (range, 11–112% and 7–110%, respectively). For the seedling growth stage, the saline treatments caused reductions in leaf area and fresh and dry biomass that averaged 63, 65, and 65% relative to the control, respectively. Overall, hierarchal cluster analyses showed differences in salt tolerance between the seedling emergence and seedling growth stages. Net photosynthetic rate decreased with salinity, but soil‐plant analysis development readings increased by an average of 18% in the EC10 treatment. Chlorophyll fluorescence did not change, but performance index tended to increase in response to salinity. Chloride concentrations in the leaf tissue increased with salinity and ranged from 32 to 111 mg g−1, with significant varietal differences.
Improving the Sustainability of Malting Barley Production: Prospects for Perennial and Annual Growth Habit Varieties
Authors: Windes Sarah , Carrijo Daniela , Curwen‐McAdams Colin , Hayes Patrick
Published: September 2019

Malted grains—principally barley (Hordeum vulgare L.) —are essential raw materials for brewing. There is an increasing demand for more sustainable crop production practices. At the same time, climate change makes it imperative to identify new production zones, systems, and crops. These demands and imperatives have stimulated interest in converting staple cereal crops, including barley, from annual to perennial growth habit. Most effort has been devoted to wheat (Triticum aestivum L.), and the most progress made in domesticating a perennial relative of wheat. These results prompt the questions: what are the prospects for developing perennial malting barley and is developing perennial malting barley the most direct path to sustainability? Malting barley is a challenge for growth habit conversion due to stringent quality parameters and the extensive infrastructure required for production, processing, and distribution. We discuss four possible paths to achieving the conversion from annual to perennial growth habit while maintaining expected levels of malting quality and agronomic performance: direct domestication, wide hybridization, manipulation of the vernalization and photoperiod sensitivity genes, and mapping annual and perennial forms of ryegrass (Lolium multiflorum L., and L. perenne. L, respectively) as a basis to identify genes conferring perenniality. We conclude that any one of these approaches would require significant, long‐term investment. Until such investment is forthcoming, we conclude that there are more cost‐effective, short‐term solutions—notably no‐till, multiple cropping, and increased emphasis on fall‐seeded barley—that could enhance the sustainability and viability of annual malting barley production.
Top 10 Plants: Increasing Awareness of Plants
Authors: Meyer Mary Hockenberry , Bumgarner Natalie , Pulte Andrew
Published: September 2019

Urbanization, lack of contact with the natural world, and growing up removed from agriculture has contributed to a void of knowledge relating to food and food production, along with a phenomenon known as plant blindness. We sought to change this lack of appreciation and understanding of plants by the creation of a “top 10” list of plants that have most shaped or influenced our respective states. Using the public interface of the Minnesota Landscape Arboretum and the State Botanic Garden of Tennessee, we engaged the public by asking for their nominations of influential plants. The public was interested in proposing and guessing the “winning” 10 plants and learning why each plant was selected. In each state, a panel of experts used six criteria to make the final selections including: cultural or spiritual, economic or industrial, environmental, health, historical, landscape, and sustenance or food. After the results were announced, multiple institutions have held educational events using this theme, including state historical and horticultural societies, universities, botanic gardens, schools, Extension Master Gardeners, 4‐H, Ag in the Classroom, and alumni associations. This article outlines how these educational campaigns were developed as well as the programs, events, and publications that were created to educate the public and the next generation about the critical importance of plants and how they contribute to our society, health, and well‐being. As Peter Raven (Emeritus Director of the Missouri Botanic Garden) said when reviewing the book The 10 Plants that Changed Minnesota, “every state would benefit from a similar effort.”
Grammatical Equivalence In “Eat, Pray, and Love” A Novel by Margaret Gilbert
Authors: Haryani Haryani
Published: September 2019

The objective of this study was to describe how Indonesian translator translated the meaning of number, gender, person, tense & aspect, and also voice (NGPTV) which proposed by Mona Baker. Besides that, a descriptive qualitative method and content analysis technique were used in analyzing 20% of data. The main results of the study were: 1). The use of number with SS category was 917 (61%); while PS and PP category were almost had the same value 314 (21%) and 264 (17%); but for SP category was only 22 (1%); 2). The use of Gender notion in GN was 248 (55%), and NG was 207 (45%); 3). The use of person was 2103 (100%); 4). The use of Tense & Aspect category in the form of Past tense, Present tense, and Future tense were different in number, they were 336 (95%), 12 (3%) and 6 (2%); 5). The use of voice in the form of AA was the biggest one in 244 (82%), but for AP and PP were only 45 (15%) and 10 (3%). However, it was found that 0% for PA category. Therefore, it concluded that the translator had been successfully translated the text in the notion of NGPTV.
Students’ Perspective on Teaching Materials of English for Management Business II In Management Department, Universitas Muria Kudus
Authors: Nuraeningsih Nuraeningsih
Published: September 2019

In the era of globalization, people around the world can have interaction for satisfying their goal in any aspect of life, such as business, politics, social and culture, education, etc. for that reason, the need of English proficiency as a global language becomes a priority. Therefore, it is compulsory for all students in formal education to learn it.   In university level, students of the non-English department must study English with varied purposes, depending on their major, at least for two credits. Generally, it is taught to support the basic major or discipline. Consequently, the materials are designed based on their needs, especially later when they get jobs. For this reason, the material adapted is called ESP (English for Specific Purposes) which aims at preparing students to meet the demands of the workplace, i.e. the English skills. It should be more contextual, real life for now and the future. If the material is authentic and in accordance with the needs of learners, they will likely be ready to work as the demands of the employer. With these objectives, the English materials need to be adjusted to the needs of users (stakeholders) so that after graduating from universities, freshmen can directly work or create jobs according to their expertise. This research aims to describe students’ perception of English teaching materials for Management department. A survey was conducted to second-semester students of Management department of Universitas Muria Kudus. The result of the study reveals that the students have a positive perspective on the teaching materials of English for Management Business II. They think affirmatively that the materials have been selected properly in terms of material attraction, usefulness, authenticity, variety, level of difficulty, language skill proportion and the discussed topics. In other words, the materials are appropriate for satisfying Management department students’ need to prepare their future. The implication is the materials should be revised by adding more reading texts of Business English and providing more vocabulary tasks in the real context.
Degradation of 1H-benzotriazole using vacuum ultraviolet: a prospective treatment method for micro-pollutants
Authors: Ye Jinshao , Hu Han , Chen Ya , Chen Yujia , Ou Huase
Published: September 2019

Benzotriazoles (BTs) attract increasing concerns because of abundant presence in environmental water bodies. In this study, degradation of 1H-benzotriazole (1H-BT) was performed by a customized vacuum ultraviolet (VUV) device emitting 185 + 254 nm (VUV/UV-C) irradiation. Degradation of 1H-BT presented an apparent rate constant reached 8.17 × 10−4 s−1. Degradation mechanisms included 185 + 254 nm photodegradation and radical reaction. The later one may be the predominant one, which presented a k·OH-1H-BT at (7.3 ± 0.8) × 109 M−1 s−1. Effects of anions revealed that VUV interception and radical trapping were the dominant restraining factors. Degradation of 1H-BT can be attributed to VUV induced radical-based oxidation. Radical-induced addition, substitution and fracture generated abundant hydroxylated and open-loop products during 10–45 min. Identification using reactive oxygen species and apoptosis in Escherichia coli was conducted. Variations of these two indicators revealed that the incomplete degradation products presented higher toxicities than 1H-BT, and a further mineralization reduced their toxicities. In the pure water solution with little impurities, VUV can induce efficient degradation of 1H-BT, suggesting its potential for eliminating and detoxifying MPs.
A autoria do CLG: uma análise à luz do conceito foucaultiano de função autor
Authors: Coelho Micaela Pafume
Published: September 2019

Neste trabalho, partimos da discussão sobre o conceito de autor, estabelecida por Foucault (1969), para mostrar que é possível sustentar, com efeito, a atribuição da autoria do Curso de Linguística Geral a Ferdinand de Saussure, dado que um autor não deve ser entendido como o indivíduo que pronuncia ou escreve um texto, mas como aquilo que dá unidade a um discurso específico.
In Silico Evaluation of the ATP7B Protein: Insights from the Role of Rare Codon Clusters and Mutations that Affect Protein Structure and Function
Authors: Mortazavi Mojtaba , Barzegar Abdolrazagh , Malekpour Abdorrasoul , Ghorbani Mohammad , Gholamzadeh Saeid , Ghasemi Younes
Published: September 2019

Background:

Wilson’s disease is a rare autosomal recessive genetic disorder of copper metabolism,
which is characterized by hepatic and neurological disease. ATP7B encodes a transmembrane
protein ATPase (ATP7B), which functions as a copper-dependent P-type ATPase. The mutations
in the gene ATP7B (on chromosome 13) lead to Wilson’s disease and is highly expressed in the liver,
kidney, and placenta. Consequently, this enzyme was considered a special topic in clinical and biotechnological
research. For in silico analysis, the 3D molecular modeling of this enzyme was conducted
in the I-TASSER web server.

Methods:

For a better evaluation, the important characteristics of this enzyme such as the rare codons
of the ATP7B gene were evaluated by online software, including a rare codon calculator (RCC),
ATGme, LaTcOm, and Sherlocc program. Additionally, the multiple sequence alignment of this enzyme
was studied. Finally, for evaluation of the effects of rare codons, the 3D structure of ATP7B was
modeled in the Swiss Model and I-TASSER web server.

Results:

The results showed that the ATP7B gene has 35 single rare codons for Arg. Additionally,
RCC detected two rare codons for Leu, 13 single rare codons for Ile and 28 rare codons for the Pro.
ATP7B gene analysis in minmax and sliding_window algorithm resulted in the identification of 16 and
17 rare codon clusters, respectively, indicating the different features of these algorithms in the detection
of RCCs. Analyzing the 3D model of ATP7B protein showed that Arg816 residue constitutes hydrogen
bonds with Glu810 and Glu816. Mutation of this residue to Ser816 cause these hydrogen bonds
not to be formed and may interfere in the proper folding of ATP7B protein. Furthermore, the side
chain of Arg1228 does not form any bond with other residues. By mutation of Arg1228 to Thr1228, a
new hydrogen bond is formed with the side chain of Arg1228. The addition and deletion of hydrogen
bonds alter the proper folding of ATP7B protein and interfere with the proper function of the ATP7B
position. On the other hand, His1069 forms the hydrogen bonds with the His880 and this hydrogen
bond adhere two regions of the protein together, which is critical in the final structural folding of
ATP7B protein.

Conclusion:

Previous studies show that synonymous and silent mutations have been linked to numerous
diseases. Given the importance of synonymous and silent mutations in diseases, the aim of this
study was to investigate the rare codons (synonymous codons) in the structure of ATP7B enzyme. By
these analyses, a new understanding was developed and our findings can further be used in some fields
of the clinical and industrial biotechnology.
Analysis of the Epigenetic Signature of Cell Reprogramming by Computational DNA Methylation Profiles
Authors: Zuo Yongchun , Song Mingmin , Li Hanshuang , Chen Xing , Cao Pengbo , Zheng Lei , Cao Guifang
Published: September 2019

Background:

DNA methylation plays an important role in the reprogramming process.
Understanding the underlying molecular mechanism of reprogramming is crucial for answering
fundamental questions regarding the transition of cell identity.

Methods:

In this study, based on the genome-wide DNA methylation data from different cell lines,
comparative methylation profiles were proposed to identify the epigenetic signature of cell
reprogramming.

Results:

The density profile of CpG methylation showed that pluripotent cells are more polarized
than Human Dermal Fibroblasts (HDF) cells. The heterogeneity of iPS has a greater deviation in
the DNA hypermethylation pattern. The result of regional distribution showed that the differential
CpG sites between pluripotent cells and HDFs tend to accumulate in the gene body and CpG shelf
regions, whereas the internal differential methylation CpG sites (DMCs) of three types of
pluripotent cells tend to accumulate in the TSS1500 region. Furthermore, a series of endogenous
markers of cell reprogramming were identified based on the integrative analysis, including focal
adhesion, pluripotency maintenance and transcription regulation. The calcium signaling pathway
was detected as one of the signatures between NT cells and iPS cells. Finally, the regional bias of
DNA methylation for key pluripotency factors was discussed. Our studies provide new insight into
the barrier identification of cell reprogramming.

Conclusion:

Our studies analyzed some epigenetic markers and barriers of nuclear reprogramming,
hoping to provide new insight into understanding the underlying molecular mechanism
of reprogramming.
Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome
Authors: Shirmohammadi Leila , Ghayour-Mobarhan Majid , Saberi-Karimian Maryam , Iranshahi Mehrdad , Tavallaie Shima , Emamian Marzieh , Sahebkar Amirhossein
Published: September 2019

Background:

Inflammation has been shown to accompany Metabolic Syndrome (MetS)
and its features. Cathepsin D is one of a proinflammatory mediator. In the current study, we aimed
to investigate the effect of curcumin supplementation on serum cathepsin D levels in patients with
MetS.

Methods:

The current study was conducted on 18-65 years old individuals with MetS diagnosed
according to the International Diabetes Federation guidelines. A total of 80 participants were
randomly divided into treatment and control groups. The first group (n=40) was given 2 capsules
containing 500 mg of phosphatidylcholine complex of curcumin, and the other group (n=40) was
given two 500 mg placebo capsules for 6 weeks. Before (week 0) and after (week 6) the intervention,
anthropometric indices and blood pressure were measured and blood samples were taken.
Serum cathepsin D was measured using an ELISA kit.

Results:

There was no significant difference between treatment and control groups in terms of
weight, body mass index, waist circumference and serum cathepsin D levels before and after the
intervention. In addition, there was no significant difference between pre- and post-trial values of
serum cathepsin D.

Conclusion:

The present results do not suggest any effect of curcumin on cathepsin D levels in
patients with MetS.
Toxicity Assessment of FeTiO2 and NiFe2O4 Nanoparticles on Aquatic Catfish (Siluriformes)
Authors: Rao Tentu Nageswara , Parvatamma Botsa , Hussain Imad , Riyazuddin  , Kumar Akshay
Published: September 2019

Background:

The aquatic toxicity of Iron doped titanium dioxide nanoparticles (FeTiO2
NPs) with an average particle size of 15 nm and a Nickel ferrite nanoparticle (NiFe2O4 NPs) with an
average particle size of 12 nm on catfish in water was investigated.

Objective:

The goal of this work is i) The synthesis and characterization of FeTiO2 NPs and NiFe2O4
NPs, ii) To prepare the different concentrations of FeTiO2 NPs and NiFe2O4 NPs, iii) Different concentrations
of NPs exposure to aquatic catfish.

Methods:

The study was conducted with different dose rates of the NPs in the water at ambient temperature
for a period of four days. During this period, abnormal behavior and mortality were observed
by visual examination. The selected dose range of FeTiO2 NPs and NiFe2O4 NPs were 0.1 to 100 mg/L
in water.

Results:

The lethal concentration for FeTiO2 NPs is > 100 mg/L and NiFe2O4 NPs were 48.6 mg/L.
During the study period, abnormal behaviors such as loss of equilibrium, pigmentation, and lying
down at the bottom of the aquaria were observed.

Conclusion:

The toxicity study of nanoparticles conducted on fish indicated that the NiFe2O4 NPs exhibited
higher toxicity as compared to the FeTiO2 NPs.
Магнитозвуковые волны в двумерной электронной ферми-жидкости
Authors: Алексеев П.С.
Published: September 2019

The properties of highly viscous fluids at high frequencies become similar to the properties of amorphous solids. In particular, it becomes possible to propagate not only longitudinal sound waves (plasmons for the case of an electron fluid), but also transverse sound waves associated with shear deformations. In this work, transverse sound waves at high frequencies in a twodimensional electron liquid in a magnetic field are studied. The consideration was carried out in the framework of the Landau Fermi-liquid model. It is shown that for a sufficiently large interaction between quasiparticles, the dynamics of excitations of a Fermi liquid is described by the equations of hydrodynamics. The Navier-Stokes equation and expressions for high-frequency shear viscosity coefficients are derived. Based on the equations obtained, the dispersion laws are calculated for transverse and longitudinal magnetosonic waves. It is shown that the cyclotron frequency, which enters in the viscosity coefficients and the dispersion law of transverse magnetosonic waves, is renormalized and typically becomes less than the usual cyclotron frequency, which determines the cyclotron resonance. The latter fact was apparently observed in the photoresistance of highly mobile GaAs quantum wells, in which two-dimensional electrons form a viscous fluid.
Моделирование с помощью молекулярной динамики низкотемпературной реконструкции поверхности (001) GaAs в процессе наноиндентирования
Authors: Прасолов Н.Д. , Гуткин А.А. , Брунков П.Н.
Published: September 2019

Using molecular dynamic technique modelling of nanoindentation of GaAs (001) surface terminated with As atoms to the depth up to 1 nm in the range of temperatures from 1 K to 15 K was carried out. It was shown that it results in to the reconstruction of a surface with formation of stable As dimers (1x2), which do not disappear after withdraw of the indenter from the surface.
Динамика импульсного перемагничивания магнитоодноосных наночастиц
Authors: Шутый А.М. , Семенцов Д.И.
Published: September 2019

The magnetic moment response of a magneto-uniaxial nanoparticle and a flat lattice of similar nanoparticles are being studied under the action of a short Gaussian pulse of a magnetic field in the presence and in the absence of its modulation. The periodic dependence of the final orientation and duration of a response of the magnetic moments on the pulse duration and its peak value have been revealed and analyzed. The effect on processes magnetization reversal of a weak magnetizing field and the deviation of the pulse of field from the transverse orientation has been studied. Have been shown that the influence of the dipole-dipole interaction leads to modulation of the response to the pulse action.
Исследование коэффициента диффузии в тонких изделиях из пористых материалов
Authors: Беляев В.П. , Мищенко С.В. , Беляев П.С.
Published: September 2019

A new method for studying mass transfer process in porous media has been considered, which allows the rapid diffusion coefficient control in thin products without destroying them and without the preliminary calibration of the diffuser concentration meter. The method provides an increase in the measurement accuracy due to the possibility of choosing the measured parameters included in the design expression. Parameters are taking from the segments of converter static characteristic. The converter has high sensitivity and noise immunity.
Обертонное комбинационное рассеяние света в монокристаллах танталата лития
Authors: Абдурахмонов С.Д. , Горелик В.С.
Published: September 2019

AbstractOvertone bands in the spectral range of 1300−1920 cm^–1 have been found in Raman scattering spectrum of lithium tantalate single crystals. The Raman spectra were recorded in the 180° scattering geometry. The intensity of overtone transitions differs for different samples and, in some cases, is comparable with the Raman scattering intensity at the fundamental modes of a lithium tantalate single crystal.
Экспериментальные исследования модели зрительной системы человека
Authors: Гулина Ю.С. , Колючкин В.Я.
Published: September 2019

AbstractThe basic principles of a multichannel model of the visual system of a human that functions as an operator performing surveillance on images formed by optoelectronic devices are described. A technique for experimental studying the model of the human visual system is proposed. The results of experimental studies aimed refining the parameters of the model of the visual system are presented. A satisfactory agreement between the calculated and experimental results indicates that the refined model of the human visual system is adequate.
Вольт-амперные характеристики и фотоэлектрический эффект гетероструктур фуллерен С-=SUB=-60-=/SUB=--4-метилфенилгидразон N-изоамилизатина
Authors: Гусев А.Н. , Мазинов А.С. , Шевченко А.И. , Тютюник А.С. , Гурченко В.С. , Брага Е.В.
Published: September 2019

The results of using N-isoamylisatin 4-methylphenylhydrazone to optimize fullerene-based heterostructures have been presented. The technique of obtaining, microscopy, as well as the results of IR spectroscopy and the study of the electrophysical properties of thin films of this hydrazone together with fullerene C60 have been described. The addition of the considered organic matter to fullerene films made it possible to increase the photoconductivity by 2 orders of magnitude compared to C60 films. The obtained thin-film structures have rectifying light-current-voltage characteristics.