bluuebunny/crossref_metadata_2025 huggingface dataset:
Intelligent Defect Identification Based on PECT Signals and an Optimized Two-Dimensional Deep Convolutional Network
Authors: Liu Baoling , He Jun , Yuan Xiaocui , Hu Huiling , Zeng Xuan , Zhu Zhifang , Peng Jie
Published: November 2020

Accurate and rapid defect identification based on pulsed eddy current testing (PECT) plays an important role in the structural integrity and health monitoring (SIHM) of in-service equipment in the renewable energy system. However, in conventional data-driven defect identification methods, the signal feature extraction is time consuming and requires expert experience. To avoid the difficulty of manual feature extraction and overcome the shortcomings of the classic deep convolutional network (DCNN), such as large memory and high computational cost, an intelligent defect recognition pipeline based on the general Warblet transform (GWT) method and optimized two-dimensional (2-D) DCNN is proposed. The GWT method is used to convert the one-dimensional (1-D) PECT signal to a 2D grayscale image used as the input of 2D DCNN. A compound method is proposed to optimize the baseline VGG16, a well-known DCNN, from four aspects including reducing the input size, adding batch normalization layer (BN) after every convolutional layer(Conv) and fully connection layer (FC), simplifying the FCs, and removing unimportant filters in Convs so as to reduce memory and computational costs while improving accuracy. Through a pulsed eddy current testing (PECT) experiment considering interference factors including liftoff and noise, the following conclusion can be obtained. The time-frequency representation (TFR) obtained by the GWT method not only has excellent ability in terms of the transient component analysis but also is less affected by the reduction of image size; the proposed optimized DCNN can accurately identify defect types without manual feature extraction. And compared to the baseline VGG16, the accuracy obtained by the optimized DCNN is improved by 7%, to about 99.58%, and the memory and computational cost are reduced by 98%. Moreover, compared with other well-known DCNNs, such as GoogLeNet, Inception V3, ResNet50, and AlexNet, the optimized network has significant advantages in terms of accuracy and computational cost, too.
Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver Cancer
Authors: Hong Seong Hwi , Son Keun Hong , Ha Sang Yun , Wee Tae In , Choi Sung Kyung , Won Ji Eun , Han Hee Dong , Ro Youngtae , Park Yeong-Min , Eun Jung Woo , Nam Suk Woo , Han Jeung-Whan , Kang Keunsoo , You Jueng Soo
Published: November 2020

The roles of chromatin remodelers and their underlying mechanisms of action in cancer remain unclear. In this study, SMARCB1, known initially as a bona fide tumor suppressor gene, was investigated in liver cancer. SMARCB1 was highly upregulated in patients with liver cancer and was associated with poor prognosis. Loss- and gain-of-function studies in liver cells revealed that SMARCB1 loss led to reduced cell proliferation, wound healing capacity, and tumor growth in vivo. Although upregulated SMARCB1 appeared to contribute to switch/sucrose nonfermentable (SWI/SNF) complex stability and integrity, it did not act using its known pathways antagonism with EZH2 or association between TP53 or AMPK. SMARCB1 knockdown induced a mild reduction in global H3K27 acetylation, and chromatin immunoprecipitation sequencing of SMARCB1 and acetylated histone H3K27 antibodies before and after SMARCB1 loss identified Nucleoporin210 (NUP210) as a critical target of SMARCB1, which bound its enhancer and changed H3K27Ac enrichment and downstream gene expression, particularly cholesterol homeostasis and xenobiotic metabolism. Notably, NUP210 was not only a putative tumor supporter involved in liver cancer but also acted as a key scaffold for SMARCB1 and P300 to chromatin. Furthermore, SMARCB1 deficiency conferred sensitivity to doxorubicin and P300 inhibitor in liver cancer cells. These findings provide insights into mechanisms underlying dysregulation of chromatin remodelers and show novel associations between nucleoporins and chromatin remodelers in cancer.

Significance:

This study reveals a novel protumorigenic role for SMARCB1 and describes valuable links between nucleoporins and chromatin remodelers in cancer by identifying NUP210 as a critical coregulator of SMARCB1 chromatin remodeling activity.
Y-Box Binding Protein-1: A Neglected Target in Pediatric Brain Tumors?
Authors: Taylor Louisa , Kerr Ian D. , Coyle Beth
Published: November 2020

Brain and central nervous system tumors represent the most common childhood solid tumors. Comprising 21% of all pediatric cancers, they remain the leading cause of cancer-related mortality and morbidity in childhood. Due to advances in neurosurgical technique, radiotherapy and the use of combination therapy, survival rates have generally increased. However, by cause of the lesion itself, its surgical removal and subsequent treatment, survivors are at high risk of long-term neurocognitive sequelae and secondary cancer. Clearly, improvements in diagnosis and treatment are needed. Accordingly, current treatment is evolving away from conventional, uniform therapy and towards risk-stratified regimens and molecularly-targeted therapies, with the aim of diminishing adverse side effects while minimizing the risk of disease recurrence. The multifunctional oncoprotein Y-box binding protein 1 (YB-1) may serve as one such molecular target. Increased YB-1 levels have been reported in a number of pediatric brain tumors, where YB-1 appears to facilitate the advancement of malignant phenotypes. These include proliferation, invasion, and resistance to therapy, as well as the maintenance of brain tumor-initiating cells. Here we evaluate the current literature and show how YB-1 modulates signaling pathways driving each of these phenotypes. We also review the regulation of YB-1 at a transcriptional, translational, posttranslational and subcellular level and argue that there is strong and sufficient evidence to support the development of YB-1 as a biomarker and future therapeutic target in childhood brain tumors.
Bilateral Impending Macular Hole, Cataract and Uveitis following Electrical Injury
Authors: Alamri Osama , Alturkistani Danya , Saifaldein Amjad , Talatt Karim
Published: November 2020

The present case describes bilateral impending macular holes, cataract and anterior uveitis in a 36-year-old male patient after having sustained a high-voltage electrical shock. Ocular complications following electrical injury have been rarely reported in the literature. To the best of our knowledge, this is the first report of bilateral high intraocular pressure, corneal epithelial keratitis, anterior uveitis cataract and impending macular holes after high-voltage electrical injury.
Validation of a Three-Item Short Form of the Modified Weight Bias Internalization Scale (WBIS-3) in the German Population
Authors: Kliem Sören , Puls Hans-Christian , Hinz Andreas , Kersting Anette , Brähler Elmar , Hilbert Anja
Published: November 2020

Introduction: Individuals suffering from overweight or obesity frequently experience weight-based stigmatization. The widespread belief that weight is a matter of personal will and self-control results in various weight-based stereotypes (e.g., laziness, lack of self-discipline, or neglect). Objective: Based on the modified version of the Weight Bias Internalization Scale (WBIS-M), a short form for the economic assessment of weight bias internalization in the general population was compiled and validated. Methods: A three-item short form (WBIS-3) was derived based on data from a representative sample of the German population (n = 1,092). This new short form was validated in a second representative population sample (n = 2,513). Item characteristics and internal consistency were obtained. Measurement invariance was tested. Construct validity was established via the correlation with theoretically related constructs (depression, anxiety, eating behavior, discrimination, weight status). To establish scale validity, all analyses were performed for the whole sample as well as for the subsample of individuals with overweight. Age- and gender-specific population norms were provided. Results: The WBIS-3 exhibited excellent psychometric properties. Internal consistency was α = 0.92. Strong measurement invariance was confirmed regarding age, gender, discrimination, and weight status in both the whole sample as well as the overweight subsample. Conclusions: The WBIS-3 constitutes a valid and economical tool for the assessment of weight bias internalization in epidemiological contexts. Measurement invariance allows for an unbiased comparison of means, correlation coefficients, and path coefficients within structural equation modeling across groups.
Acute Myeloid Leukemia Presenting as a Cardiac Mass
Authors: Magzoub Mohamed Alia , Saleh Maysa , Alzarawani Fatima , El-kholy Nermeen
Published: November 2020

Leukemias are the most common childhood malignancy. It is a systemic disease presenting with different signs and symptoms. Extramedullary manifestations, in particular myeloid sarcoma (MS), are extremely rare, often challenging to identify, even more challenging to diagnose, and more than often misdiagnosed owing to its similarity with other solid tumors. We describe a previously healthy boy, aged 4 years, who had a cardiac mass lesion, presumed to be a MS, noted in the right atrium at the time of initial routine echocardiography. The lesion resolved without surgical intervention following the institution of multi-agent chemotherapy.
Worse Response to Ursodeoxycholic Acid in Primary Biliary Cholangitis Patients with Autoimmune Hepatitis Features
Authors: Wen Maoyao , Men Ruoting , Fan Xiaoli , Shen Yi , Ni Ping , Hu Zhichao , Yang Li
Published: November 2020

Background: There is limited evidence on the treatment response of primary biliary cholangitis (PBC) with autoimmune hepatitis (AIH) features but not meet the criteria of PBC-AIH syndromes. The aim of this study was to elucidate the clinical characteristics of PBC patients with features of AIH. Methods: We included patients with diagnostic criteria of PBC. All patients were treated with ursodeoxycholic acid (UDCA) and without immunosuppressive agents for >1 year. The biochemical response was evaluated at 1 year after the treatment of UDCA. Results: Among 432 patients with PBC, 166 (38.4%) patients did not achieve biochemical response within 1 year of UDCA treatment. Nonresponders had a lower albumin level and higher immunoglobulin G, alanine transaminase (ALT), alanine aminotransferase (AST), alkaline phosphatase, glutamyl transpeptidase and total bilirubin levels (p < 0.05). The response rates were significantly lower in patients with elevated level of IgG or ALT or AST. Moreover, the higher the IgG or AST level was, the lower the response rate was in patients with PBC, regardless of cirrhosis. For patients with cirrhosis, there was no differences among patients with different levels of ALT. Patients in the PBC with AIH features group had a significant lower response rate than patients in the PBC-only group. Among the 139 patients who underwent liver biopsy, 54 were nonresponsive to UDCA and 48 (88.9%) shown mild interface hepatitis. Conclusion: In conclusion, PBC patients with AIH features had a worse response to UDCA therapy.
Automatically Evolving Texture Image Descriptors Using the Multitree Representation in Genetic Programming Using Few Instances
Authors: Al-Sahaf Harith , Al-Sahaf Ausama , Xue Bing , Zhang Mengjie
Published: November 2020

The performance of image classification is highly dependent on the quality of the extracted features that are used to build a model. Designing such features usually requires prior knowledge of the domain and is often undertaken by a domain expert who, if available, is very costly to employ. Automating the process of designing such features can largely reduce the cost and efforts associated with this task. Image descriptors, such as local binary patterns, have emerged in computer vision, and aim at detecting keypoints, for example, corners, line-segments, and shapes, in an image and extracting features from those keypoints. In this article, genetic programming (GP) is used to automatically evolve an image descriptor using only two instances per class by utilising a multitree program representation. The automatically evolved descriptor operates directly on the raw pixel values of an image and generates the corresponding feature vector. Seven well-known datasets were adapted to the few-shot setting and used to assess the performance of the proposed method and compared against six handcrafted and one evolutionary computation-based image descriptor as well as three convolutional neural network (CNN) based methods. The experimental results show that the new method has significantly outperformed the competitor image descriptors and CNN-based methods. Furthermore, different patterns have been identified from analysing the evolved programs.
A Christian Response to Global Conflict: Realism and Reconciliation
Authors: Jacob Cecilia
Published: November 2020

This article considers avenues for fruitful engagement between international relations and public theology in order to ask what an ethical Christian response to global conflict should entail. The process of mediating principles of biblical justice into a contemporary international context requires interpretation in a reality of territorial bounded states, with rules and norms governing international interactions that are unique to the present day. This article draws on two theologically oriented contributions to international relations, Christian realism and political reconciliation to probe the question as to how we conceptualise justice as a pursuit in international relations from a Christian worldview. It reflects on the contingencies of the present-day context of global conflict, and the implications for praxis from a public theology standpoint.
Negative-Emission Technologies and Patent Rights after COVID-19
Authors: Sarnoff Joshua D.
Published: November 2020

Governmental and particularly private funding has recently and dramatically expanded for both beccs and dac technologies. This funding and the associated research, development, and deployment efforts will generate intellectual property rights, particularly patent rights in nets. As with access to medicines, the COVID-19 pandemic has highlighted concerns that patent rights may incentivize RD&D at the cost of affordable access to the relevant technologies. Further, access may be restricted to particular countries based on sovereignty concerns to seek preferential supply agreements through up-front funding. As a result, nations will likely turn to controversial ex-post measures, such as compulsory licensing, to assure access and to control prices of the needed technologies. The same concerns with patent rights likely will affect RD&D of nets. Although international ex-ante measures exist (such as patent pools) which would help to minimize these concerns, such measures may not induce the requisite voluntary contributions, or may fail to materialize due to political disagreements. Focusing on both US law and international developments, this article proposes various ex-ante measures that can be adopted by national governments and private funders to minimize the likely forthcoming worldwide conflicts that will arise over balancing innovation incentives for, and affordable access to, patented nets.
Carl Jung, John Layard and Jordan Peterson
Authors: Clark Gary
Published: November 2020

In this article I discuss the relationship between analytical psychology and theories of human social evolution. More specifically I look at debates in evolutionary studies and anthropology regarding the priority of matrilineal social structure in the emergence ofHomo sapiens. These debates were occurring in the late nineteenth and early twentieth centuries and they provide the context for many of the assumptions of psychoanalysis and analytical psychology. In this essay I will explore these issues in relation to analytical psychology. I will also discuss the work of anthropologist John Layard who proposed matriliny was humanity’s original form of social organisation. Interestingly, Layard’s field work had significant impact on Jung. I will also compare the work of Layard, and other theorists who adopt matrilineal theories of human social evolution, with the theories of Jordan Peterson. Peterson has developed an idiosyncratic evolutionary conception of analytical psychology, one in which he explicitly rejects the notion of matrilineal priority in human evolution. He also adopts certain assumptions about the evolutionary origins of contemporary socio-political hierarchy, assumptions I argue are not supported by data from numerous fields of scientific enquiry.
Cities as Emergent International Actors in the Field of Migration
Authors: Thouez Colleen
Published: November 2020

Cities are fast becoming actors on issues of transnational import. This is also true in the field of migration governance where their scope of responsibility has traditionally been perceived as entirely domestic in nature. As mayors act and advocate transnationally on migration, they are supported by a growing web of intercity networks spanning knowledge sharing, to lobbying, to operational work. In parallel, cities’ agency is rising as they begin to acquire access and influence in interstate deliberations and decision-making fora. Their active presence impacts policy instruments like the UN Global Compact for Migration and Global Compact on Refugees, and policy frameworks like the Global Forum on Migration and Development. In turn, as cities provide more information on challenges faced locally, we may expect more pragmatic approaches to migration. This article outlines this expansion of cities’ agency and what it could mean for international migration governance.
Are There Mathematical Hinges?
Authors: Coliva Annalisa
Published: November 2020

In this paper I argue that, contrary to what several prominent scholars of On Certainty have claimed, Wittgenstein did not maintain that simple mathematical propositions like “2 × 2 = 4” or “12 × 12 = 144,” much like G. E. Moore’s truisms, could be examples of hinge propositions. In particular, given his overall conception of mathematics, it was impossible for him to single out these simpler mathematical propositions from the rest of mathematical statements, to reserve only to them a normative function. I then maintain that these mathematical examples were introduced merely as objects of comparison to bring out some peculiar features of the only hinges he countenanced in On Certainty, which were all outside the realm of mathematics. I then close by gesturing at how the distinction between mathematical hinges and non-hinges could be exemplified and by exploring its consequences with respect to (Wittgenstein’s) philosophy of mathematics.
Two new species of the genus Ancyronyx Erichson, 1847 from the island of Negros, Philippines (Insecta, Coleoptera, Elmidae)
Authors: Sabordo Marc Ryan , Delocado Emmanuel , Freitag Hendrik
Published: November 2020

Two new Elmidae species from the Visayan island of Negros, Philippines, Ancyronyx berghaueri sp. n. and Ancyronyx negrosensis sp. n., are described utilizing an integrative taxonomic approach. The new species are characterized by the color of the femora, body size, and the male and female genitalia. Their habitus and diagnostic characters are described and illustrated in detail with microscopic images and digital line drawings. The morphological species delimitation is supplemented by and congruent with COI and cob mtDNA data of several known species of Ancyronyx from the Philippines and Borneo. The material was obtained in connection with a student thesis, the sampling program of the Ateneo de Manila University Biodiversity Laboratory and from repositories. Specimens were collected at altitudes between 30 m and 800 m above sea level in pristine and slightly disturbed habitats. Their suitability as bioindicators and the use of cob sequences for integrative taxonomic studies are briefly discussed.
New Perspectives on West Africa and World War Two
Authors: Coates Oliver
Published: November 2020

Focusing on Anglophone West Africa, particularly Nigeria and the Gold Coast (Ghana), this article analyses the historiography of World War Two, examining recruitment, civil defence, intelligence gathering, combat, demobilisation, and the predicament of ex-servicemen. It argues that we must avoid an overly homogeneous notion of African participation in the war, and that we should instead attempt to distinguish between combatants and non-combatants, as well as differentiating in terms of geography and education, all variables that made a significant difference to wartime labour conditions and post-war prospects. It will show how the existing historiography facilitates an appreciation of the role of West Africans in distinct theatres of combat, and examine the role of such sources as African war memoirs, journalism and photography in developing our understanding of Africans in East Africa, South and South-East Asia, and the Middle East. More generally, it will demonstrate how recent scholarship has further complicated our comprehension of the conflict, opening new fields of study such as the interaction of gender and warfare, the role of religion in colonial armed forces, and the transnational experiences of West Africans during the war. The article concludes with a discussion of the historical memory of the war in contemporary West African fiction and documentary film.
Walls and Gates, Windows and Mirrors: Urban Defences, Cultural Memory, and Security Theatre in Song Kaifeng
Authors: Levine Ari Daniel
Published: November 2020

Kaifeng, the capital of the Northern Song (960-1127) dynasty, boasted sophisticated siege defence installations, which were ultimately breached by the Jurchen invasion of 1126-1127. According to both the archaeological and textual evidence, its concentric city walls and militarized gates with barbicans and bastions represented a crucial stage in the militarization of urban form in early-modern China, as well as a more open approach to planning. While Kaifeng’s urban defences evoked imperial majesty and personal security for Northern Song residents who described them, diasporic literati of the Southern Song (1127-1279) invoked the violation of this defensive perimeter as a metonym for the invasion of their lost homeland. The concept of security theatre explains how Northern Song Kaifeng’s city walls and gates could simultaneously function as efficacious siege defence installations and be perceived as symbolic defences.
Numerical Tables in Chinese Writings Devoted to Mathematics: From Early Imperial Manuscripts to Printed Song-Yuan Books
Authors: Chemla Karine
Published: November 2020

This article establishes that the discursive parts of the earliest known mathematical manuscripts in Chinese were composed of (at least) two types of elements, marked by two types of texts. The manuscripts alternate continuous text, and text for numerical tables (what I call table-relations). I show that in these manuscripts, the latter were written down as ‘textual tables,’ and that two basic types of style were used for these textual tables. By contrast, tabular layouts have been used for a Qin period object and a Dunhuang manuscript carrying numerical tables. I suggest that these artifacts should be interpreted as computing tools. I further argue that, at least from the eleventh century onwards, diagrammatic tables were introduced into mathematical writings. They were used to write down new types of numerical tables. Diagrammatic features of such texts, like horizontal, vertical and oblique lines, played a key part in the reading, interpretation and use of these table-relations. In this sense, they can be compared with the Qin computing tool. I conclude that the fact that in Song-Yuan times these diagrammatic tables are referred to as ‘diagram tu 圖’ curiously echoes with the history of visual tools attested to in relation to mathematical activity in China.
Reading the Corpse in Forensic Casebooks of Nineteenth Century China
Authors: Xin-zhe Xie
Published: November 2020

This article examines two forensic casebooks from nineteenth century China. Forensic cases are among the favored sources for progressive narratives sketching out the development of forensic knowledge as a process through which anomalies are detected and explained, and new facts are ultimately incorporated into the existing corpus of knowledge. This article is aimed at providing an alternative view. It first argues that cases revealing a serious discrepancy vis-à-vis the official manual for autopsies are extremely few. It later demonstrates that, instead of accumulating facts challenging the authoritative manual, forensic case compilers primarily addressed the question of weighing evidence. They singled out cases which shed light on how to make a decision in the face of several competing, but already-known symptoms. Each case displays how the weighing process worked out depending on its particular and unrepeatable circumstantial configuration, with no intent to convey generalizable information. Collecting precedents is thus not intended to form new claims as opposed to the canonical manual, but to make it more applicable to a complex reality. Forensic case compilers, therefore, did not evaluate the official manual in terms of correctness or inaccuracy, exhaustiveness or deficiency. What really mattered was flexibility in using the book depending on the actual circumstances.
A Scholarly Imprint: How Tibetan Astronomers Brought Jesuit Astronomy to Tibet
Authors: Yongdan Lobsang
Published: November 2020

The European Jesuits’ mission to China during the seventeenth and eighteenth centuries is considered a world-historical event that played an important role in the transmission of knowledge between the West and the East. In spite of its historical significance, it was long assumed that the Jesuit mission to China and its scientific scholarship had never reached the mountainous regions of Tibet. As I have described elsewhere, this was not the case. Between the eighteenth and nineteenth centuries, Tibetans not only translated a large number of the Jesuits’ works into Tibetan, they also reformed the Tibetan calendar in accordance with the Jesuit-influenced calendar of the Qing. How did it happen and in which way? It was a twofold process achieved partially with Qing imperial sponsorship and partially on the Tibetans’ own initiative, sometimes even in a low-key, indirect and secretive way. In this article, I shall look at how a Tibetan Buddhist astronomer at the imperial court in Beijing wrote a manual for predicting solar and lunar eclipses. I will also look at how some Tibetan astronomers brought this imperial knowledge, apparently without explicit imperial approval, to the monasteries in Amdo, the North-East of Tibet, which mostly lies today in the Chinese provinces of Qinghai and Gansu, as well as how Tibetan astronomers in this region reformed their calendars according to the Jesuits’ astronomical system. Finally, I will describe how this tradition, in spite of recent political upheaval and tragedies, is still alive and practiced in Tibet.
‘The Observations We Made in the Indies and in China’: The Shaping of the Jesuits’ Knowledge of China by Other Parts of the Non-Western World
Authors: Huiyi Wu
Published: November 2020

The Jesuits’ experience in China is usually analysed within the framework of Sino-Western relations. However, Jesuits’ writings often evoked their experience in and knowledge about China in association with other parts of the non-European world, including India, South-East Asia, the Middle East, Africa and America. Based on a prosopographical analysis of China Jesuits’ biographical data, we first demonstrate that the encounter with other non-European regions was an integral part of the China Jesuits’ itineraries; for they all travelled through intermediate areas on their way to China, and some also did so on their way back to Europe. Secondly, relying mainly on examples drawn from French Jesuits’ scholarship between the 1680s and the 1750s, we demonstrate how encounters with other non- European regions and the overseas interests of their home country shaped the Jesuits’ scientific agenda as well as the way they understood things Chinese. Lastly, we illustrate how Jesuits keenly studied historical and contemporaneous accounts in Chinese and Manchu on the neighbouring regions of the Qing empire. We argue that the body of knowledge produced by the China Jesuits should be studied in a spatial framework that goes beyond the China-Europe dichotomy since it was, on one hand, filtered by the Jesuits’ knowledge about other non-European regions and, on the other hand, concerned with a geographical area larger than the territory of China under the Ming and even the Qing dynasty. We also argue that, in the eighteenth century in particular, the China Jesuits’ scholarship was configured by the spatial dynamics shaping the Society of Jesus, Bourbon France and Qing China; thereby, we contribute to a better understanding of both the French Jesuit and Qing networks, and the interconnections between them.
Elixir, Urine and Hormone: A Socio-cultural History of Qiushi (Autumn Mineral)
Authors: Zhu Jing
Published: November 2020

Traditional Chinese medicine has attracted the attention of pharmacologists because some of its remedies have proved useful against cancer and malaria. However, a variety of controversies have arisen regarding the difficulty of identifying and explaining the effectiveness of remedies by biomedical criteria. By exploring the socio-cultural history of qiushi (literally, ‘autumn mineral’), a drug prepared from urine and used frequently throughout Chinese history, I examine how alchemy, popular culture, politics and ritual influenced pre-modern views of the efficacy of the drug, and explore the sharp contrast between views of the drug’s function and efficacy in the context of Chinese medicine and contemporary biomedical knowledge. Questioning the biomedical hypothesis that qiushi contains sex hormones, I find that the popular, centuries-long use of qiushi correlates with the efficacy of what has been called ‘the meaning response,’ the merging of alchemy and medicine, the influence of social relations, and the division and mixture of theory and practical use.
A Missing Link in the History of Chinese Medicine: Research Note on the Medical Contents of the Taishō Tripiṭaka
Authors: Pierce Salguero C.
Published: November 2020

Numerous texts were produced roughly between 150 and 1100 CE that introduced Indian medicine to East Asia. These have historically represented a relatively discrete corpus of health-related knowledge, relatively unintegrated into Chinese medicine and often ignored in mainstream Chinese medical historiography. Buddhist texts do not provide straightforward evidence of a unitary tradition of healing that was transplanted from India to China. However, these sources are critical to understanding the history of medicine in medieval China. In addition, it is not an exaggeration to say that this corpus offers one of the most voluminous sources of textual evidence for the transregional communication and reception of medical ideas in first millennium CE Asia that is available anywhere. Despite the fact that over the long term they were not nearly as significant in Chinese medical history as classical medical models, Buddhist ideas and practices deserve more attention than they have received thus far from our field. This brief research note is meant to introduce historians of Chinese medicine to one easily accessible collection of texts that can be used to begin to fill in this ‘missing link.’
Hacking the Yak: The Chinese Effort to Improve a Tibetan Animal in the Early Twentieth Century
Authors: Frank Mark E.
Published: November 2020

This article considers the roles of yak bodies in relations between Han Chinese and Khampa Tibetan communities during the early twentieth century. It argues that bovine bodies were sites of Han-Tibetan interaction wherein culture, biology, and locality were intertwined. I chronicle the earliest large-scale engagement of the Chinese state with yak pastoralism in the context of its efforts to consolidate control over the eastern Tibetan region of Kham. Yak husbandry is traditionally an enterprise of Tibetans and other Himalayan ethnic groups, but the yak was targeted for ‘improvement’ by Han Chinese modernizers beginning in the 1930s. An effort to decouple the yak from its Tibetan cultural context at the Taining Experimental Zone saw mixed results. Livestock scientists there made modest gains in productivity, yet they did so by approximating to a high degree the nomadic mode of production from which they were attempting to extract the yak.
A new subgenus and eight new species of Guimaraesiella Eichler, 1949 (Phthiraptera: Ischnocera: Philopteridae: Brueelia-complex)
Authors: GUSTAFSSON DANIEL R. , BUSH SARAH E.
Published: November 2020

The species of the chewing louse genus Guimaraesiella Eichler, 1949 parasitic on drongos (Dicruridae) are reviewed and placed in the new subgenus Dicrurobates, which is described herein together with eight new species, including one species from non-dicrurid hosts. The new species are: Guimaraesiella (Dicrurobates) carbonivora n. sp. from Dicrurus bracteatus carbonarius Bonaparte, 1850; Guimaraesiella (Dicrurobates) latitemporalis n. sp. from Dicrurus hottentottus brevirostris (Cabanis, 1851) and Dicrurus hottentottus ssp. (Linnaeus, 1766); Guimaraesiella (Dicrurobates) lurida n. sp. from Dicrurus leucophaeus Vieillot, 1817; Guimaraesiella (Dicrurobates) luzonica n. sp. from Dicrurus balicassius (Linnaeus, 1766); Guimaraesiella (Dicrurobates) nana n. sp. from Dicrurus hottentottus samarensis Vaurie, 1947; Guimaraesiella (Dicrurobates) regis n. sp. from Dicrurus annectans (Hodgson, 1836), Dicrurus paradiseus paradiseus (Linnaeus, 1766) and Dicrurus paradiseus rangoonensis (Gould, 13836); Guimaraesiella (Dicrurobates) transvaalensis n. sp. from Dicrurus adsimilis apivorus Clancey, 1976; and Guimaraesiella (Dicrurobates) campanula n. sp. from Oriolus larvatus rolleti Salvadori, 1864 and Prionops plumatus poliocephalus (Stanley, 1814). Also, Guimaraesiella (Dicrurobates) sexmaculata (Piaget, 1880) and Guimaraesiella (Dicrurobates) dicruri (Ansari, 1955) are redescribed and illustrated. A key to identify adults of all 10 species included in the subgenus is provided.
Collembola Poduromorpha from two littoral areas of northern Rio de Janeiro, Brazil
Authors: DA SILVEIRA TATIANA CRISTINA , DE MENDONÇA MARIA CLEIDE
Published: November 2020

Knowledge on Poduromorpha fauna from the littoral of Rio de Janeiro mainly come from studies conducted in “restinga” areas of Itaipuaçu, Maricá, and Marambaia. In this study two “restinga” areas were sampled for the first time to increase the taxonomic knowledge of Poduromorpha in littoral areas of Rio de Janeiro: Costa do Sol State Park and Restinga de Jurubatiba National Park, located respectively at Lake Region (“região dos lagos”) and at northern Rio de Janeiro State. The analysis of the material showed the presence of six families, 14 genera and 20 species. All records are new for both areas; Neanuridae had the highest diversity, with seven genera and 10 species. One of them, Paleonura Cassagnau, 1982, was registered for the first time in the littoral of Rio de Janeiro. A key was proposed for the Poduromorpha genera found in the littoral of Rio de Janeiro.
Annotated catalogue of the click-beetle genera Hapatesus Candѐze, 1863 and Toorongus Neboiss, 1957 (Coleoptera: Elateridae) from the Australasian realm
Authors: HOFFMANNOVA JOHANA , KUNDRATA ROBIN
Published: November 2020

An annotated catalogue of the genera Hapatesus Candѐze, 1863 and Toorongus Neboiss, 1957 (Coleoptera: Elateridae) is presented. Altogether, 21 species are classified in Hapatesus (of which five in the subgenus Minutesus Neboiss, 1957), and four in Toorongus. The species of Hapatesus are distributed in Australia, New Guinea, the Bismarck Archipelago and New Zealand, and there are also dubious reports from Taiwan, India and Uganda. Toorongus, on the other hand, is an endemic of Australia. For each taxon we provide synonyms, information on types, type localities, distribution, and bibliography. The systematic placement and distribution of the above-mentioned genera are briefly discussed.
A new species of the subgenus Idopterum Hampson, 1894 of the genus Ammatho Walker, 1855 from China (Lepidoptera: Erebidae: Arctiinae: Lithosiini), with redefinition of the subgenus Idopterum
Authors: HUANG SI-YAO , VOLYNKIN ANTON V. , WANG MIN , FAN XIAO-LING
Published: November 2020

A new species of the subgenus Idopterum Hampson, 1894 of the genus Ammatho Walker, 1855, Ammatho (Idopterum) wuchunshengi Huang, Volynkin & Wang sp. nov. is described from southeastern Yunnan, Southwestern China. The autapomorphies of Idopterum are redefined and the features in juxta and aedeagus vesica are corrected and added, respectively. Adults and genitalia of the new species and related species are illustrated.
Re-evaluation of the genus Biapertura Smirnov, 1971 (Cladocera: Anomopoda: Chydoridae)
Authors: SINEV ARTEM Y.
Published: November 2020

The genus Biapertura Smirnov, 1971, with type species B. affinis (= Lynceus affinis Leydig, 1860) is re-evaluated, removing the affinis-group from polyphyletic Alona s. lato. Biapertura s. str. is a taxon which could be defined by large size (up to 1.1 mm), having head shield with triangular posterior portion and two connected major head pores, and by having massive postabdomen with over 10 well-developed composite marginal denticles and well-developed lateral fascicles of setulae. Thoracic limbs of Biapertura are of Hexalona-type, inner distal lobe of limb I bear extremely large, usually claw-like seta 1. Australian species of the genus, B. kendallensis (Henry, 1919) and B. elliptica (Sinev, 1997), are fully redescribed here. Morphological analysis suggests that Biapertura s. str. is a sister-group to Alona s. str. A key to seven species of the genus is provided and a discussion of their geographic distribution and habitat type is given.
The South American species of Chalcis Fabricius (Hymenoptera: Chalcididae)
Authors: SAGUIAH PÂMELLA MACHADO , MOLIN ANA DAL , TAVARES MARCELO TEIXEIRA
Published: November 2020

Chalcis Fabricius (Hymenoptera: Chalcididae) currently includes over 50 described species, most of them from temperate regions of the Northern Hemisphere. Prior to the present study, only Chalcis pilicauda (Cameron) had been recorded from South America. The examination of specimens collected in Argentina, southern Bolivia, Brazil, Ecuador, Paraguay, and Uruguay allowed the description of six new species: C. boi Saguiah & Tavares sp. nov., C. danunciae Saguiah & Tavares sp. nov., C. intervalensis Saguiah & Tavares sp. nov., C. periotoi Saguiah & Tavares sp. nov., C. quechua Saguiah & Tavares sp. nov., and C. winstonae Saguiah & Tavares sp. nov. Chalcis pilicauda is redescribed, and C. ornatifrons (Cameron) stat. rev. is removed from synonym under C. pilicauda and re-established. An identification key for South American species is presented.
A Continuum Approach to Understanding Changes in the ENSO–Indian Monsoon Relationship
Authors: Schulte Justin , Policelli Frederick , Zaitchik Benjamin
Published: November 2020

It is well documented that the relationship between the El Niño–Southern Oscillation (ENSO) and the Indian summer monsoon changes on interdecadal time scales, yet an explanation for the variations is still a subject of debate. Here, using a continuum framework based on one-point partial correlation maps, we show that the ENSO–Indian rainfall relationship is influenced by the gradient of sea surface temperature anomalies (SSTA) across the Niño-3 region. Based on this identified SSTA pattern, a simple trans-Niño-3 (TN3) index is created that explains up to 50% of all-India rainfall variability during the mid- to late monsoon season after the 1960s. It is also shown that the influence of the TN3 pattern on the relationship between common ENSO metrics and all-India rainfall is strongest during the August–September (AS) monsoon subseason and weakest during the June–July subseason. The TN3 pattern accounts for up to 80% of the change and sign reversal in the AS Niño-1+2–all-India rainfall relationship in recent decades. The 1940s coincides with the intensification of the TN3 pattern and its influence. As the TN3 index is nearly orthogonal to the Niño-3 index, and both are strongly correlated with all-India rainfall, the strengthening TN3 influence must be systematically associated with the weakening Niño-3–all-India relationship in recent decades. This work supports arguments that recent changes in the ENSO–Indian rainfall relationship are not solely related to noise.
Utility of triage shock index in predicting patient outcome in calcium channel blocker poisoning
Authors: Lau Man Ting , Wong Cheung Lun William
Published: November 2020

Introduction:

Shock index is defined as heart rate divided by systolic blood pressure. It is reported as a predictor of morbidity and mortality in trauma and acute myocardial infarction in previous studies. It may be valuable in evaluation of calcium channel blocker poisoning. The objective of this study is to examine the probability of serious outcome based on first measured shock index in patients who presented to emergency department with calcium channel blocker poisoning.

Methods:

A retrospective chart review was conducted on calcium channel blocker poisoning cases in Hong Kong Poison Information Centre from 1 July 2008 to 30 June 2017. Shock index was calculated with blood pressure and pulse measurement at emergency department triage. Odds ratios of various variables for major outcome, mortality, intensive care unit admission, length of stay in acute hospital were calculated by multivariate analysis or negative binomial regression where appropriate. The performance of shock index in predicting major outcome was evaluated with receiver operating characteristic curve.

Results:

A total of 390 cases were identified, of whom 25.1% developed major outcome and 5.6% died. Shock index showed significant association with major outcome (odds ratio: 17.017, 95% confidence interval: 5.521–52.455). The area under the receiver operating characteristic curve for shock index in predicting major outcome was 0.7008 (95% confidence interval: 0.64–0.76).

Conclusion:

Higher shock index is associated with worse patient outcome in calcium channel blocker poisoning. However, shock index alone is not reliable in predicting patient outcome. Further research is needed before shock index can be incorporated for use in patient management in poisoning with calcium channel blocker or other anti‐hypertensives.
Zircon from diamondiferous kyanite gneisses of the Kokchetav massif: Revealing growth stages using an integrated cathodoluminescence, Raman spectroscopy and electron microprobe approach
Authors: Rezvukhina Olga V. , Korsakov Andrey V. , Rezvukhin Dmitriy I. , Mikhailenko Denis S. , Zamyatin Dmitry A. , Greshnyakov Evgeny D. , Shur Vladimir Ya.
Published: November 2020

Zircon crystals from diamondiferous kyanite gneisses of the Barchi-Kol area (Kokchetav massif, Northern Kazakhstan) have been investigated by a combined application of cathodoluminescence (CL), Raman spectroscopy and electron probe microanalysis (EPMA). The zircon crystals exhibit up to four distinct domains characterised by significantly different CL signatures and parameters of the ν3(SiO4) (1008 cm–1) Raman band (i.e. full width at half maximum, position and intensity). Extremely metamict zircon cores (Domain I) host inclusions of low-pressure minerals (quartz and graphite) and the outer mantles (Domain III) are populated by ultrahigh-pressure relicts (diamond and coesite), whereas inner mantles (Domain II) and overgrowth rim zones (Domain IV) are inclusion free. Both the zircon cores and rims have very low Ti concentrations, implying formation temperatures below 760°C. The Ti content in the inner mantles (up to 40 ppm) is indicative of temperatures in the 760–880°C range. The temperature estimates for the outer mantles are 900–940°C, indicating a pronounced overlap with the peak metamorphic values yielded by the Zr-in-rutile geothermometer for the same rocks (910–950°C). The internal textures of the zircons and the occurrence of index minerals within the distinct domains allow us to unravel the stages of the complex metamorphic history recorded in the zircon. Our data show that the zircon cores are inherited seeds of pre-metamorphic (magmatic?) origin, the inner mantles were formed on the prograde metamorphic stage, the outer mantles record ultrahigh-pressure metamorphism and the outermost rims mark the retrograde metamorphic stage. The observed zircon internal textures are thus clearly correlated with distinct growth events, and in some examples reflect a major part of the metamorphic history. It is concluded that the combined application of the CL, Raman spectroscopy and EPMA techniques to zircon offers significant potential for deciphering the metamorphic evolution of deeply-subducted rocks.
Macrophage protease-activated receptor 2 regulates fetal liver erythropoiesis in mice
Authors: Saffarzadeh Mona , Grunz Kristin , Nguyen T. Son , Lee Young K. , Kitano Maki , Danckwardt Sven , Rodrigues Carina D. S. , Weiler Hartmut , Reyda Sabine , Ruf Wolfram
Published: November 2020

Deficiencies in many coagulation factors and protease-activated receptors (PARs) affect embryonic development. We describe a defect in definitive erythropoiesis in PAR2-deficient mice. Embryonic PAR2 deficiency increases embryonic death associated with variably severe anemia in comparison with PAR2-expressing embryos. PAR2-deficient fetal livers display reduced macrophage densities, erythroblastic island areas, and messenger RNA expression levels of markers for erythropoiesis and macrophages. Coagulation factor synthesis in the liver coincides with expanding fetal liver hematopoiesis during midgestation, and embryonic factor VII (FVII) deficiency impairs liver macrophage development. Cleavage-insensitive PAR2-mutant mice recapitulate the hematopoiesis defect of PAR2-deficient embryos, and macrophage-expressed PAR2 directly supports erythroblastic island function and the differentiation of red blood cells in the fetal liver. Conditional deletion of PAR2 in macrophages impairs erythropoiesis, as well as increases inflammatory stress, as evidenced by upregulation of interferon-regulated hepcidin antimicrobial peptide. In contrast, postnatal macrophage PAR2 deficiency does not have any effect on steady-state Kupffer cells, bone marrow macrophage numbers, or erythropoiesis, but erythropoiesis in macrophages from PAR2-deficient mice is impaired following hemolysis. These data identify a novel function for macrophage PAR2 signaling in adapting to rapid increases in blood demand during gestational development and postnatal erythropoiesis under stress conditions.
Correction to: Ion microprobe dating of fissure monazite in the Western Alps: insights from the Argentera Massif and the Piemontais and Briançonnais Zones
Authors: Ricchi Emmanuelle , Gnos Edwin , Rubatto Daniela , Whitehouse Martin John , Pettke Thomas
Published: November 2020

An amendment to this paper has been published and can be accessed via the original article.