bluuebunny/crossref_metadata_2025 huggingface dataset:
A National Evaluation of Surgeon Experiences in Telemedicine for the Care of Hernia and Abdominal Core Health Patients
Authors: Nikolian Vahagn C. , Akhter Mudassir , Iqbal Emaad J. , Sutton Thomas , Samhan Ashraf , Orenstein Sean B. , Rosen Michael J. , Poulose Benjamin K.
Published: October 2021

Background

Surgeons are increasingly utilizing telemedicine to provide perioperative services to patients. Safety, satisfaction, and feasibility of these programs in general populations have been established, but it is unclear how telemedicine can be integrated into subspecialty care. We report results of a national survey related to telehealth practices among members of the Abdominal Core Health Quality Collaborative (ACHQC).

Methods

Survey responses were analyzed to determine current strategies in telemedicine utilization. Surgeon preferences, perceptions of validity, and identified barriers to implementation of telemedicine were assessed.

Results

Forty surgeons within the ACHQC responded, with 90% of respondents reporting use of telemedicine to deliver perioperative care to patients with hernias and abdominal core health concerns. Surgeons appeared to be more comfortable managing preoperative patients with image‐confirmed diagnoses of hernias. Surgeons were universally more comfortable delivering postoperative care via telemedicine. Connectivity, patient engagement, and reimbursement were identified as potential barriers to expansion of telemedicine. Seventy‐eight percent of respondents reported that they would increase telemedicine utilization if current regulations were maintained in the future.

Conclusions

This study found that hernia specialists are utilizing telemedicine at a higher rate than before the COVID‐19 pandemic, with surgeons reporting interest in continued use of this modality beyond the pandemic. These findings suggest that future work in telemedicine optimization may improve the quality of care that can be delivered to patients with abdominal core health concerns.
Role of umbilicocerebral and cerebroplacental ratios in prediction of perinatal outcome in FGR pregnancies
Authors: Coenen H. , Braun J. , Köster H. , Möllers M. , Schmitz R. , Steinhard J. , Oelmeier K.
Published: October 2021

Purpose

Aim of our study was to compare the prognostic value of the Umbilical-to-Cerebral ratio (UCR) directly to the Cerebroplacental ratio (CPR) in the prediction of poor perinatal outcomes in pregnancies complicated by Fetal Growth Restriction (FGR).

Methods

A retrospective study was carried out on pregnant women with either a small-for-gestational age (SGA) fetus or that were diagnosed with FGR. Doppler measurements of the two subgroups were assessed and the correlation between CPR, UCR and relevant outcome parameters was evaluated by performing linear regression analysis, binary logistic analysis and receiver operator characteristic (ROC) curves. Outcomes of interest were mode of delivery, acidosis, preterm delivery, gestational age at birth as well as birthweight and centiles.

Results

Boxplots and Scatterplots illustrated the different distribution of CPR and UCR leading to deviant correlational relationships with adverse outcome parameters. In almost all parameters examined, UCR showed a higher independent association with preterm delivery (OR: 5.85, CI 2.23–15.34), APGAR score < 7 (OR: 3.52; CI 1.58–7.85) as well as weight under 10th centile (OR: 2.04; CI 0.97–4.28) in binary logistic regression compared to CPR which was only associated with preterm delivery (OR: 0.38; CI 0.22–0.66) and APGAR score < 7 (OR: 0.27; CI 0.06–1.13). When combined with different ultrasound parameters in order to differentiate between SGA and FGR during pregnancy, odds ratios for UCR were highly significant compared to odds ratios for CPR (OR: 0.065, 0.168–0.901; p = 0.027; OR: 0.810, 0.369–1.781; p = 0.601). ROC curves plotted for CPR and UCR showed almost identical moderate prediction performance.

Conclusion

Since UCR is a better discriminator of Doppler values in abnormal range it presents a viable option to Doppler parameters and ratios that are used in clinical practice. UCR and CPR showed equal prognostic accuracy conserning sensitivity and specificity for adverse perinatal outcome, while adding UA PI and GA_scan increased prognostic accuracy regarding negative outcomes.
Risk of cardiovascular disease in patients with fatty liver disease as defined from the metabolic dysfunction associated fatty liver disease or nonalcoholic fatty liver disease point of view: a retrospective nationwide claims database study in Japan
Authors: Yoneda Masato , Yamamoto Takuma , Honda Yasushi , Imajo Kento , Ogawa Yuji , Kessoku Takaomi , Kobayashi Takashi , Nogami Asako , Higurashi Takuma , Kato Shingo , Hosono Kunihiro , Saito Satoru , Nakajima Atsushi
Published: October 2021

Background

Nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction associated fatty liver disease (MAFLD) have important associations with cardiovascular disease (CVD). The main objective of this study was to compare the frequency of incidence rate of CVD in the NAFLD or MAFLD patients utilizing a large claims database.

Methods

Using the JMDC database from April 2013 to March 2019, we retrospectively analyzed data for 1,542,688 and 2,452,949 people to estimate the relationship between CVD and NAFLD, MAFLD, respectively.

Results

The incidence rates of CVD were 0.97 (95% CI 0.94–1.01) and 2.82 (95% CI 2.64–3.01) per 1000 person-years in the non-NAFLD and NAFLD groups, respectively, and 1.01 (95% CI 0.98–1.03) and 2.69 (95% CI 2.55–2.83) per 1000 person-years in the non-MAFLD and MAFLD groups, respectively. The overall prevalence of hypertriglyceridemia and diabetes mellitus (DM) was 13.1, and 4.2%, respectively, in the non-NAFLD group and 63.6, and 20.2%, respectively, in the NAFLD group. The overall prevalenceof hypertriglyceridemia and DM was 13.6 and 4.3%, respectively, in the non-MAFLD group and 64.1, and 20.6%, respectively, in the MAFLD group. HRs for CVD increased with hypertriglyceridemia and DM.

Conclusions

Results indicated that incident rate of CVD increased with NAFLD/MAFLD; the complication rate of DM and hypertriglyceridemia among NAFLD/MAFLD patients is high and may affect the development of CVD.
Dynamic analysis of railway bridges exposed to high-speed trains considering the vehicle–track–bridge–soil interaction
Authors: König Paul , Salcher Patrick , Adam Christoph , Hirzinger Benjamin
Published: October 2021

A new semi-analytical approach to analyze the dynamic response of railway bridges subjected to high-speed trains is presented. The bridge is modeled as an Euler–Bernoulli beam on viscoelastic supports that account for the flexibility and damping of the underlying soil. The track is represented by an Euler–Bernoulli beam on viscoelastic bedding. Complex modal expansion of the bridge and track models is performed considering non-classical damping, and coupling of the two subsystems is achieved by component mode synthesis (CMS). The resulting system of equations is coupled with a moving mass–spring–damper (MSD) system of the passing train using a discrete substructuring technique (DST). To validate the presented modeling approach, its results are compared with those of a finite element model. In an application, the influence of the soil–structure interaction, the track subsystem, and geometric imperfections due to track irregularities on the dynamic response of an example bridge is demonstrated.
Fairness in rankings and recommendations: an overview
Authors: Pitoura Evaggelia , Stefanidis Kostas , Koutrika Georgia
Published: October 2021

We increasingly depend on a variety of data-driven algorithmic systems to assist us in many aspects of life. Search engines and recommender systems among others are used as sources of information and to help us in making all sort of decisions from selecting restaurants and books, to choosing friends and careers. This has given rise to important concerns regarding the fairness of such systems. In this work, we aim at presenting a toolkit of definitions, models and methods used for ensuring fairness in rankings and recommendations. Our objectives are threefold: (a) to provide a solid framework on a novel, quickly evolving and impactful domain, (b) to present related methods and put them into perspective and (c) to highlight open challenges and research paths for future work.
Heterogeneity of Staphylococcus epidermidis in prosthetic joint infections: time to reevaluate microbiological criteria?
Authors: Widerström Micael , Stegger Marc , Johansson Anders , Gurram Bharat Kumar , Larsen Anders Rhod , Wallinder Lars , Edebro Helen , Monsen Tor
Published: October 2021

Prosthetic joint infection (PJI) is a feared and challenging to diagnose complication after arthroplasty, with Staphylococcus epidermidis as the major pathogen. One important criteria to define PJI is the detection of phenotypically indistinguishable microorganisms with identical antibiotic susceptibility pattern in at least two different samples. However, owing to phenotypical variation within genetic clones and clonal variation within a phenotype, the criteria may be ambiguous. We investigated the extent of diversity among coagulase-negative staphylococci (CoNS) in PJI and characterised S. epidermidis isolates from PJI samples, specifically multiple S. epidermidis isolates identified in individual PJI patients. We performed a retrospective cohort study on 62 consecutive patients with PJI caused by CoNS from two hospitals in Northern Sweden. In 16/62 (26%) PJIs, multiple S. epidermidis isolates were available for whole-genome analyses. Hospital-adapted multidrug-resistant genetic clones of S. epidermidis were identified in samples from 40/62 (65%) of the patients using a combination of pulsed-field gel electrophoresis and multilocus sequence typing. Whole-genome sequencing showed the presence of multiple sequence types (STs) in 7/16 (44%) PJIs where multiple S. epidermidis isolates were available. Within-patient phenotypical variation in the antibiotic susceptibility and/or whole-genome antibiotic resistance gene content was frequent (11/16, 69%) among isolates with the same ST. The results highlight the ambiguity of S. epidermidis phenotypic characterisation as a diagnostic method in PJI and call for larger systematic studies for determining the frequency of CoNS diversity in PJIs, the implications of such diversity for microbiological diagnostics, and the therapeutic outcomes in patients.
The immunohistochemical expression of SSTR2A is an independent prognostic factor in meningioma
Authors: Fodi Christina , Skardelly Marco , Hempel Johann-Martin , Hoffmann Elgin , Castaneda Salvador , Tabatabai Ghazaleh , Honegger Jürgen , Tatagiba Marcos , Schittenhelm Jens , Behling Felix
Published: October 2021

The expression of somatostatin receptors in meningioma is well established. First, suggestions of a prognostic impact of SSTRs in meningioma have been made. However, the knowledge is based on few investigations in small cohorts. We recently analyzed the expression of all five known SSTRs in a large cohort of over 700 meningiomas and demonstrated significant correlations with WHO tumor grade and other clinical characteristics. We therefore expanded our dataset and additionally collected information about radiographic tumor recurrence and progression as well as clinically relevant factors (gender, age, extent of resection, WHO grade, tumor location, adjuvant radiotherapy, neurofibromatosis type 2, primary/recurrent tumor) for a comprehensive prognostic multivariate analysis (n = 666). The immunohistochemical expression scores of SSTR1, 2A, 3, 4, and 5 were scored using an intensity distribution score ranging from 0 to 12. For recurrence-free progression analysis, a cutoff at an intensity distribution score of 6 was used. Univariate analysis demonstrated a higher rate of tumor recurrence for increased expression scores for SSTR2A, SSTR3, and SSTR4 (p = 0.0312, p = 0.0351, and p = 0.0390, respectively), while high expression levels of SSTR1 showed less frequent tumor recurrences (p = 0.0012). In the Kaplan–Meier analysis, a higher intensity distribution score showed a favorable prognosis for SSTR1 (p = 0.0158) and an unfavorable prognosis for SSTR2A (0.0143). The negative prognostic impact of higher SSTR2A expression remained a significant factor in the multivariate analysis (RR 1.69, p = 0.0060). We conclude that the expression of SSTR2A has an independent prognostic value regarding meningioma recurrence.
Probabilistic modelling and verification using RoboChart and PRISM
Authors: Ye Kangfeng , Cavalcanti Ana , Foster Simon , Miyazawa Alvaro , Woodcock Jim
Published: October 2021

RoboChart is a timed domain-specific language for robotics, distinctive in its support for automated verification by model checking and theorem proving. Since uncertainty is an essential part of robotic systems, we present here an extension to RoboChart to model uncertainty using probabilism. The extension enriches RoboChart state machines with probability through a new construct: probabilistic junctions as the source of transitions with a probability value. RoboChart has an accompanying tool, called RoboTool, for modelling and verification of functional and real-time behaviour. We present here also an automatic technique, implemented in RoboTool, to transform a RoboChart model into a PRISM model for verification. We have extended the property language of RoboTool so that probabilistic properties expressed in temporal logic can be written using controlled natural language.
Use of non-lethal endpoints to establish water quality requirements and optima of the endangered Topeka shiner (Notropis topeka)
Authors: Mott Rory T. , Rosenberger Amanda E. , Novinger Doug
Published: October 2021

Water quality standards based on sub-lethal effects and performance optima for aquatic organisms, rather than onset of mortality, are more ecologically relevant for management of species of conservation concern. We investigated the effects of hypoxia, temperature (with acclimation), nitrogenous chemical compounds, and chloride on Topeka shiners (Notropis topeka) by monitoring behavioral responses to a reduction in oxygen and, using swimming speed, determining thermal optima and onset of effect for concentrations of nitrogenous compounds and chloride. We found ASR50 (i.e., dissolved oxygen concentrations where 50% of fish use aquatic surface respiration) to be 1.65 mg/L and ASR90 to be 1.08 mg/L of dissolved oxygen. Optimum temperatures for the species ranged from 17.7 to 28.0 °C, while predicted 100% mortality ranged from 33.7 to 40.3 °C, depending on the temperature at which fish were acclimated prior to experiments. Ammonia and sodium chloride reduced swimming speed at concentrations below known LC50 values, while nitrite concentrations did not correspond with swimming speed, but rather, post-experiment mortality. This provides insight into where Topeka shiners can not only persist, but also thrive. Although swimming speed may not be a suitable metric for determining the effects of all contaminants, our focus on optima and sub-lethal effects over tolerance allows selections of the most suitable reintroduction site matching the species’ physiological profile.
Balanced sampling of boxes from batches for assessing quality of fruits and vegetables in EU countries
Authors: Franceschi Sara , Betti Gianni , Fattorini Lorenzo , Gagliardi Francesca , Montrone Gianni
Published: October 2021

The best evaluation for the proportion of defective units in a batch of fruits and vegetables can be achieved by an exhaustive checking of all the boxes in the batch, that is prohibitive to perform in most cases. Usually, only a sample of boxes is checked. In EU countries, EU regulations establish to estimate the proportion of defective units in a batch by the proportion of defective units in the sample, without giving any rule for selecting boxes. Therefore, results are highly dependent on the subjective choice of boxes. In the present study, an objective design-based approach is considered to select boxes from batches, adopting balanced spatial schemes with equal inclusion probabilities. The schemes are able to select samples of boxes evenly spread throughout the batch also ensuring good statistical properties for the proportion of defective units in the sample as estimator of the proportion of defective units in the batch. The performance of these strategies is evaluated by means of a simulation study performed on real and artificial batches of apples, peppers and strawberries. A case study is considered to estimate the proportion of defective units in a batch of courgettes stored in a distribution center of a supermarket chain in Central Italy.
Metabolic profiles identify circulating biomarkers associated with heart failure in young single ventricle patients
Authors: O’Connell Thomas M. , Logsdon David L. , Mitscher Gloria , Payne R. Mark
Published: October 2021

Background

Children and young adults with single ventricle (SV) heart disease frequently develop heart failure (HF) that is intractable and difficult to treat. Our understanding of the molecular and biochemical reasons underlying this is imperfect. Thus, there is an urgent need for biomarkers that predict outcome and provide a rational basis for treatment, and advance our understanding of the basis of HF.

Objective

We sought to determine if a metabolomic approach would provide biochemical signatures of HF in SV children and young adults. If significant, these analytes might serve as biomarkers to predict outcome and inform on the biological mechanism(s) of HF.

Methods

We applied a multi-platform metabolomics approach composed of mass spectrometry (MS) and nuclear magnetic resonance (NMR) which yielded 495 and 26 metabolite measurements respectively. The plasma samples came from a cross-sectional set of young SV subjects, ages 2–19 years with ten control (Con) subjects and 16 SV subjects. Of the SV subjects, nine were diagnosed as congestive HF (SVHF), and 7 were not in HF. Metabolomic data were correlated with clinical status to determine if there was a signature associated with HF.

Results

There were no differences in age, height, weight or sex between the 3 cohorts. However, statistical analysis of the metabolomic profiles using ANOVA revealed 44 metabolites with significant differences between cohorts including 41 profiled by MS and 3 by NMR. These metabolites included acylcarnitines, amino acids, and bile acids, which distinguished Con from all SV subjects. Furthermore, metabolite profiles could distinguish between SV and SVHF subjects.

Conclusion

These are the first data to demonstrate a clear metabolomic signature associated with HF in children and young adults with SV. Larger studies are warranted to determine if these findings are predictive of progression to HF in time to provide intervention.
The circular economy and the Green Jobs creation
Authors: Sulich Adam , Sołoducho-Pelc Letycja
Published: October 2021

The circular economy (CE) is a proposal for a new, more sustainable, and durable economy model. As a consequence, this pro-environmental economic model induces visible changes in the labor market which are Green Jobs (GJs). This paper is focused on the creation of Green Jobs in the CE. The GJs are most visible in the environmental goods and services sector (EGSS). This study aims to investigate EGSS among 28 European Union countries in the years 2009–2019. The adopted method was literature research complemented by the statistical analysis of secondary data from Eurostat in the linear regression method. Then, some Sustainable Development Goals (SDGs) and their measure were used as main indicators reflecting changes in the labor market. Results are presented as a model indicating which of the SDGs can support CE and enhance a number of the Green Jobs. Presented results contribute to the science because combine factors influencing GJs creation in EGSS, in a CE perspective. This study underlines a lack of uniform methods for measuring and forecasting the effects of Green Jobs creation and indicates future research directions.
The Role of Plasma Exchange in the Treatment of Refractory Autoimmune Neurological Diseases: a Narrative Review
Authors: Jacob Saiju , Mazibrada Gordon , Irani Sarosh R , Jacob Anu , Yudina Anna
Published: October 2021

Autoimmune neurological disorders are commonly treated with immunosuppressive therapy. In patients with refractory conditions, standard immunosuppression is often insufficient for complete recovery or to prevent relapses. These patients rely on other treatments to manage their disease. While treatment of refractory cases differs between diseases, intravenous immunoglobulin, plasma exchange (PLEX), and immune-modulating treatments are commonly used. In this review, we focus on five autoimmune neurological disorders that were the themes of the 2018 Midlands Neurological Society meeting on PLEX in refractory neurology: Autoimmune Encephalitis (AE), Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum disorders (NMOSD), Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) and Myasthenia Gravis (MG). The diagnosis of inflammatory neuropathies is often challenging, and while PLEX can be very effective in refractory autoimmune diseases, its ineffectiveness can be confounded by misdiagnosis. One example is POEMS syndrome (characterized by Polyneuropathy Organomegaly, Endocrinopathy, Myeloma protein, Skin changes), which is often wrongly diagnosed as CIDP; and while CIDP responds well to PLEX, POEMS does not. Accurate diagnosis is therefore essential. Success rates can also differ within ‘one’ disease: e.g. response rates to PLEX are considerably higher in refractory relapsing remitting MS compared to primary or secondary progressive MS. When sufficient efforts are made to correctly pinpoint the diagnosis along with the type and subtype of refractory autoimmune disease, PLEX and other immunotherapies can play a valuable role in the patient management.

Graphical abstract
The influence of job crafting on the quality of care provided by nursing home employees: The moderating effect of organizational identification
Authors: Romeo Marina , Yepes-Baldó Montserrat , Nordin Maria , Westerberg Kristina , Lundmark Robert , Morales Pamela
Published: October 2021

Our goal was to analyze the positive effect of job crafting activities involving nursing home employees on their perceived quality of care, and the moderating effect of organizational identification. A two-wave non-experimental design (with an interval of 12 months) was used. The Job Crafting Questionnaire, the Identification-Commitment Inventory, and the Quality of Care Questionnaire (QoC) were administered to 226 nursing home employees in two waves. The results of the hierarchical regression analyses found significant association between job crafting subdimensions and quality of care twelve months later. Organizational identification was shown to play a moderating role in these relationships when analyzing the effect of cognitive crafting. In this sense, the effect of cognitive crafting on quality of care is only found with high levels of identification. The findings highlight the importance of the job crafting dimensions (task, relational and cognitive) when it comes to enhancing quality of care in residential homes for the elderly. This is especially relevant for cognitive crafting among employees with high levels of organizational identification. This research provides managers with guidance when allocating job crafting opportunities aimed at making improvements in quality of care. In this respect, organizations must offer job crafting training to stimulate and support their employees and, on the other hand, managers should encourage employees to craft their jobs, gearing their needs, abilities, and goals to corporate values and competencies.
A progressive development of a visual analysis interface of climate-related VGI
Authors: Navarra Carlo , Vrotsou Katerina , Opach Tomasz , Joling Almar , Wilk Julie , Neset Tina-Simone
Published: October 2021

This paper describes the progressive development of three approaches of successively increasing analytic functionality for visually exploring and analysing climate-related volunteered geographic information. The information is collected in the CitizenSensing project within which urban citizens voluntarily submit reports of site-specific extreme weather conditions, their impacts, and recommendations for best-practice adaptation measures. The work has pursued an iterative development process where the limitations of one approach have become the trigger for the subsequent ones. The proposed visual exploration approaches are: an initial map application providing a low-level data overview, a visual analysis prototype comprising three visual dashboards for more in-depth exploration, and a final custom-made visual analysis interface, the CitizenSensing Visual Analysis Interface (CS-VAI), which enables the flexible multifaceted exploration of the climate-related geographic information in focus. The approaches developed in this work are assessed with volunteered data collected in two of the CitizenSensing project’s campaigns held in the city of Norrköping, Sweden.
Statistical analysis of the best GIS interpolation method for bearing capacity estimation in An-Najaf City, Iraq
Authors: Al-Mamoori Sohaib Kareem , Al-Maliki Laheab A. , Al-Sulttani Ahmed Hashem , El-Tawil Khaled , Al-Ansari Nadhir
Published: October 2021

The presence of an economical solution to predict soil behaviour is essential for new construction areas. This paper aims to investigate the ultimate interpolation method for predicting the soil bearing capacity of An-Najaf city-Iraq based on field investigation information. Firstly, the engineering bearing capacity was calculated based on the in-site N-SPT values using dynamic loading for 464 boreholes with depths of 0–2 m, using the Meyerhof formula. The data then were classified and imported to the GIS program to apply the interpolation methods. Four deterministic and two geostatistical interpolation methods were applied to produce six bearing capacity maps. The statistical analyses were performed using two methods: the common cross-validation method by the coefficient of determination (R2) and root mean square error (RMSE), where the results showed that ordinary kriging (OK) is the ultimate method with the least RMSE and highest R2. These results were confusing so, the backward elimination regression (BER) procedure was applied to gain the definite result. The results of BER show that among all the deterministic methods, the IDW is the optimal and most significant interpolation method. The result of geostatistical methods shows that EBK is the best method in our case than the OK method. BER also applied to all six methods and shows that IDW is the ultimate significant method. The results indicate no general ultimate interpolation method for all cases and datasets type; therefore, the statistical analyses must be performed for each case and dataset.
Managing Water and Wetlands Based on the Tayal’s Interpretation of Utux and Gaga
Authors: Song Kuoyung Silan , LePage Ben , Fang Wei-Ta
Published: October 2021

Humans first appeared on the planet about 3.5 million years ago and like most biota, they settled near wetlands because of the availability of food and water. The ancestors of our species understood and knew that water, wetlands, and healthy landscapes were essential for life. In Taiwan, the indigenous people have a long history being a part of and managing the natural resources, including wetlands in their respective habitats. Water and wetlands still play a substantial and significant role in the manner that the Tayal, an indigenous group of people in Taiwan use, preserve, care, protect, respect, and share the habitats and natural resources within which they live. The evolution of Taiwan’s tribal cultures, and probably most cultures on the planet are closely entwined with the resources present in each tribe’s habitat, especially water and wetlands. DNA results indicate 2 lineages of people migrated to Taiwan between 11,000 and 26,000 years ago and gave rise to 9 ethnic groups (Tajima et al. 2003). Today 16 indigenous cultures/tribes are recognized with each occupying different regions of Taiwan’s diverse landscape. Each tribe has its own language and culture and occupies its own geographic region, which contributes to Taiwan’s rich cultural history and diversity. The Tayal tribe is one of the larger tribes with about 88,000 people and the Smangus people are a subset of the Tayal tribe with a culture that is at least 6,000 years old. Culturally, the Tayal people consider themselves to be an element of the environment and their culture is defined by their relationship and interactions with the environment, including all of the other biotic, abiotic elements present in their habitats. In this paper we provide an overview of Tayal culture and philosophy, which determines how the Tayal people manage and protect their natural resources, especially water and wetlands following the tenets ofUtuxandGagathat comprise the entirety of their core cultural values. The cultural and language variations, nuances, environmental interpretations, and management techniques are specific to tribal groups and differences in geographic location and environmental settings.
Preparation and evaluation of novel functional fermented dairy products containing propolis and cinnamon
Authors: Gunes-Bayir Ayşe , Bilgin Mehmet Gültekin , Guclu Duygu , Pogda Sultan , Dadak Agnes
Published: October 2021

Novel functional food products might be an easy accessible and eligible approach to help reduce the risk of severe viral infections including SARS-CoV-2. Hence a product containing probiotics, propolis and cinnamon was developed and interferences of the ingredients were characterized. Yogurts were prepared using starter cultures with propolis (0.03%) and cinnamon in various concentrations (0.3%, 1%, and 2.5%). Bifidobacterium animalis ssp. lactis, Lactobacillus acidophilus, Streptococcus thermophilus, and Lactobacillus delbrueckii subsp. bulgaricus were used as microorganisms for yogurt production. Chemical analysis revealed a decline of fat matter in the presence of propolis and/or cinnamon. Propolis had statistically significant suppressive effects on Bifidobacterium animalis ssp. lactis as well as on Lactobacillus delbrueckii subsp. bulgaricus numbers (p < 0.05). These effects were diminished in the presence of increasing cinnamon concentrations. For Lactobacillus acidophilus a statistically significant reducing effect on the number of colonies was observed in all products investigated. Nevertheless all samples met the standard of recommended level of ≥ 106 viable cells/g of a product. Propolis showed an inverse effect on Streptococcus thermophilus by increasing its colony numbers in yogurts. The probiotic yogurt samples containing propolis (0.03%) and cinnamon (2.5%) gained the highest number of points in the sensory evaluation compared to control.
Assessing the change of groundwater quality compared with land-use change and precipitation rate (Zrebar Lake's Basin)
Authors: Sadeghi Azad , Galalizadeh Saman , Zehtabian Gholamreza , Khosravi Hassan
Published: October 2021

Population, salinity, and increasing water consumption have caused high pressure on groundwater resources in Iran. The study reported here investigates the change of groundwater quality in Zrebar lake basin and the relationship between it with land-use change and precipitation rate from 1992 to 2018. To achieve the intended goal, chemical parameters of water from wells around the lake, bicarbonate (HCO3−), sulfate (SO4), sodium absorption ratio (SAR), and electrical conductivity (EC) were analyzed. Then, four methods including interpolation in the ArcGIS environment, Wilcox and Schoeller Diagram in Aq.QA software and Ground Water Quality Index (GWQI) were used to indicate the trend of water quality from 1992 to 2018. To detect land-use changes from 1992 to 2018, three Landsat satellite images covering the study area were used to identify land uses and their changes during the period that shows a significant area of forests that has been replaced by agricultural use, the dominant cover in 2018, while the area of forest has declined sharply. In this study, the precipitation patterns over the past years were showed to assess the relationship between rainy and low rainfall years with water quality. The results showed that forest area in 1992, 2003 and 2018 was 70.6, 62.5 and 50.2 hectares, respectively, which shows a significant reduction, 22%, during this study period. On the other hand, the area of farmlands and human-made constructions has increased by 20% and 200%, respectively. This study additionally revealed that although there was a decreasing trend in the rate of rainfall and the agricultural lands have increased, the quality of water was still suitable for drinking and agriculture consumptions. Changes in groundwater quality were not justifiable by rainfall rate and land-use change because there was no significant relationship between them with all the groundwater quality parameters.
Evaluating the role of community detection in improving influence maximization heuristics
Authors: Hajdu László , Krész Miklós , Bóta András
Published: October 2021

Both community detection and influence maximization are well-researched fields of network science. Here, we investigate how several popular community detection algorithms can be used as part of a heuristic approach to influence maximization. The heuristic is based on the community value, a node-based metric defined on the outputs of overlapping community detection algorithms. This metric is used to select nodes as high influence candidates for expanding the set of influential nodes. Our aim in this paper is twofold. First, we evaluate the performance of eight frequently used overlapping community detection algorithms on this specific task to show how much improvement can be gained compared to the originally proposed method of Kempe et al. Second, selecting the community detection algorithm(s) with the best performance, we propose a variant of the influence maximization heuristic with significantly reduced runtime, at the cost of slightly reduced quality of the output. We use both artificial benchmarks and real-life networks to evaluate the performance of our approach.
Clinical epigenetics and restoring of metabolic health in severely obese patients undergoing batriatric and metabolic surgery
Authors: Faenza Mario , Benincasa Giuditta , Docimo Ludovico , Nicoletti Giovanni Francesco , Napoli Claudio
Published: October 2021

Epigenetic-sensitive mechanisms, mainly DNA methylation, mirror the relationship between environmental and genetic risk factors able to affect the sensitiveness to development of obesity and its comorbidities. Bariatric and metabolic surgery may reduce obesity-related cardiovascular risk through tissue-specific DNA methylation changes. Among the most robust results, differential promoter methylation of ACACA, CETP, CTGF, S100A8, and S100A9 genes correlated significantly with the levels of mRNA before and after gastric bypass surgery (RYGB) in obese women. Additionally, promoter hypermethylation of NFKB1 gene was significantly associated with reduced blood pressure in obese patients after RYGB suggesting useful non-invasive biomarkers. Of note, sperm-related DNA methylation signatures of genes regulating the central control of appetite, such as MC4R, BDNF, NPY, and CR1, and other genes including FTO, CHST8, and SH2B1 were different in obese patients as compared to non-obese subjects and patients who lost weight after RYGB surgery. Importantly, transgenerational studies provided relevant evidence of the potential effect of bariatric and metabolic surgery on DNA methylation. For example, peripheral blood biospecimens isolated from siblings born from obese mothers before bariatric surgery showed different methylation signatures in the insulin receptor and leptin signaling axis as compared to siblings born from post-obese mothers who underwent surgery. This evidence suggests that bariatric and metabolic surgery of mothers may affect the epigenetic profiles of the offspring with potential implication for primary prevention of severe obesity. We update on tissue-specific epigenetic signatures as potential mechanisms underlying the restoration of metabolic health after surgery suggesting useful predictive biomarkers.
Long-term outcomes of sleeve gastrectomy as a revisional procedure after failed gastric band: a multicenter cross-matched cohort study
Authors: de Angelis Francesco , Boru Cristian Eugeniu , Iossa Angelo , Perotta Nicola , Campanile Fabio Cesare , Silecchia Gianfranco
Published: October 2021

Laparoscopic adjustable gastric band (LAGB) is the bariatric procedure most likely subject to revisional surgery. Both laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (LRYGB) represent viable options, but the long-term results are still lacking. In 2014, we published the 2-year follow-up of our multicenter cohort of revisional LSG after failed LAGB. Evaluate the long-term follow-up (median 9.3 years) of the same cohort of patients. University and primary-care hospitals, Italy. We retrospectively examined a prospectively maintained database of the previously published multicenter cohort of 56 patients who underwent LSG after failed LAGB between 2008–2011. The control group included cross-matched non-revisional LSGs. The primary endpoint was weight loss, secondary endpoints co-morbidities, and the need for further bariatric surgery. The study group included 44 patients and the control group 56. We found %EWL 53% Vs. 67% (p = .021), %EBMIL (54 Vs. 68%, p = .018), %TWL (26 Vs. 34%, p = .002). We also found more severe GERD (gastroesophageal reflux disease) symptoms in the revisional than in the primary group (9.0 vs. 1.8% mild and 23.0 vs. 3.0% severe). Ten patients from the revisional group (22.7%) vs. eight in the primary group (13%) underwent further bariatric surgery (LRYGB). Our results showed less favorable weight loss in revisional than primary LSG after LABG, higher prevalence of GERD, and a more frequent need for further revisional surgery. Despite the study’s limitations, the present data suggest that the long-term outcomes may offset the possible reduced short-term complication rate after revisional sleeve gastrectomy for a failed LABG.
New Bounds on the Double Total Domination Number of Graphs
Authors: Cabrera-Martínez A. , Hernández-Mira F. A.
Published: October 2021

Let G be a graph of minimum degree at least two. A set $$D\subseteq V(G)$$

D
⊆
V
(
G
)

is said to be a double total dominating set of G if $$|N(v)\cap D|\ge 2$$

|
N
(
v
)
∩
D
|
≥
2

for every vertex $$v\in V(G)$$

v
∈
V
(
G
)

. The minimum cardinality among all double total dominating sets of G is the double total domination number of G. In this article, we continue with the study of this parameter. In particular, we provide new bounds on the double total domination number in terms of other domination parameters. Some of our results are tight bounds that improve some well-known results.
Mortality rate and factors associated with death in traumatic chest injury patients: A retrospective study
Authors: Yimam Abubeker Eshetu , Mustofa Salh Yalew , Gebregzi Amare H/kiros , Aytolign Habtu Adane
Published: October 2021

ABSTRACT

Background:

Traumatic chest injury is responsible for 10%–15% of all trauma-related hospital admissions across the world. It is also responsible for approximately 25% of trauma related death. Several predictors have been described for mortality following chest trauma however, limited published studies were available in Ethiopia.

Objective:

To assess mortality rate and factors associated with death in traumatic chest injury patients over five year's period from June 2016 to June 30, 2020 G.C.

Method:

A retrospective cross-sectional study was done from June 2016 to June 30, 2020. Data was collected from patients’ chart. The collected data was entered into Epi-info version 7 and transferred to SPSS version 20.0 for processing and analysis. Bivariable and multivariable logistic regression was used to show factors associated with mortality. P- Value < 0.05 was considered statistically significant.

Result:

A total of 419 patient charts were eligible for this study. The majority of patients (55.8%) sustained blunt chest injuries and violence (52.5%) was the leading cause of injuries. Hemopneumothorax (27.7.0%), hemothorax (22.9%) and rib fracture (17.2%% were the most common type of injuries. Associated extra-thoracic injuries were noted in 70.4% of patients, from those, extremity injury (22.2%), head/neck injuries (21.7%) and abdominal injuries (18.1%) were the commonest. Most patients (64.7%) were treated successfully with chest tube. Nearly, one third (35.3%) had complications including pneumonia (13.8%) and Atelectasis (12.6%). The mean length of hospital stay was 9.40 days. The overall traumatic chest injury mortality rate was 26%. Mortality was significantly associated with age >50 year [AOR 9.32, 95% CI, 2.72–31.86], late presentation beyond 6hr (AOR 7.17, 95% CI 1.76–29.21), bilateral chest injury (AOR 3.58 95% CI 1.53–8.38), penetrating chest injury (AOR 3.63 95% CI 1.65–7.98), presence of extra-thoracic injury (AOR 4.80, 95% CI, 1.47–15.72) and need for mechanical ventilation (AOR 11.18, 95% CI 2.11–59.23).

Conclusion:

The mortality rate in traumatic chest injury was high. Late presentation beyond 6hr, age >50-year, penetrating injury, bilateral chest injury, associated extra thoracic injury, and need for mechanical ventilation were identified as possible risk factors for mortality in traumatic chest injury patients.

Highlights
Impaired Sexual Function in Young Women with PCOS: The Detrimental Effect of Anovulation
Authors: Mantzou Dimitra , Stamou Maria I. , Armeni Anastasia K. , Roupas Nikolaos D. , Assimakopoulos Konstantinos , Adonakis George , Georgopoulos Neoklis A. , Markantes Georgios K.
Published: October 2021

Background

Even though polycystic ovary syndrome (PCOS) is a common reproductive disorder affecting young women, its impact on their sexual health is not well known.

Aim

To examine the different aspects of female sexuality in young women with PCOS and attempt to associate hormonal changes and ovulatory status with their sexual function.

Methods

Anthropometric characteristics, hormonal levels and sexual function based on the Female Sexual Function Index (FSFI) questionnaire were assessed in 76 young women with PCOS and 133 matched controls.

Outcomes

Sexual function is significantly impaired in young women with PCOS.

RESULTS

Women with PCOS demonstrated lower scores than controls in arousal (5.04 ± 1.19 vs 4.48 ± 1.44, P < .001), lubrication (5.29 ± 1.17 vs 4.69 ± 1.54, P < .001), orgasm (4.78 ± 1.40 vs 4.11 ± 1.61, P = .001), satisfaction (5.22 ± 1.10 vs 4.78 ± 1.31, P = .016), and total score of the FSFI (29.51 ± 5.83 vs 26.76 ± 6.81, P < .001), even after correction for BMI. When corrected for total testosterone, the domains of lubrication, satisfaction, and total score of FSFI remained significantly impaired in women with PCOS (P values .037, .024, & .044 respectively). In multivariate logistic regression analysis, after adjusting for the effect of BMI and hormone levels, dysfunction in orgasm, satisfaction and the total FSFI score were still 3–4 times more common in PCOS (adjusted OR [95% CI]: 3.54, P = .020; 2.96, P = .050; 3.87, P = .027). Even though no statistically significant differences were observed between women with ovulatory PCOS and controls, we detected statistically significant differences in all domains of sexual function apart from pain between controls and PCOS women with anovulation (desire P value .04, arousal P value <.001, lubrication P value <.001, orgasm P value .001, satisfaction P value .001 and FSFI total score P value <.001).

Clinical Implications

Women with PCOS have compromised sexual function, which is independent of their BMI and highly dependent on their ovulatory status.

Strengths and Limitations

This is the first study in women with PCOS that implicates anovulation as a risk factor for sexual impairment in PCOS. Further studies are needed to elucidate the mechanisms implicated and to examine the effect of PCOS therapy on the patients’ sexual function.

CONCLUSION

The adverse effect of PCOS status on the female sexual function is independent of BMI and only partially dependent on hormonal changes characterizing the syndrome. Anovulation appears to be the major determinant of sexual impairment among women with PCOS.
Hedging the Price Risk Inherent in Revenue Protection Insurance
Authors: Tiwari Sweta , Coble Keith H. , Barnett Barry J. , Harri Ardian
Published: October 2021

Crop revenue insurance is unique, because it involves a guarantee subsuming yield risk and highly systematic price risk. This study examines whether crop insurers could use options instead of, or in addition to, assigning policies to the Commercial Funds of the USDA Federal Crop Insurance Corporation (FCIC) as per the Standard Reinsurance Agreement (SRA) to hedge the price risk of revenue insurance policies. The behavioral model examines the optimal hedge ratio for a crop insurer with a book of business consisting of corn Revenue Protection (RP) policies. Results show that a mix of put and call options can hedge the price risk of the RP policies. The higher optimal hedge ratios of call options as compared to put options imply that the risk of increased liability due to upside price risk can be hedged using options better than downside price risk. This study also analyzed the combination of options with the SRA at 35, 50, and 75% retention levels. The zero optimal hedge ratios at each retention level and the negative correlation between RP indemnities and the option returns when the crop insurer mixed options and SRA suggest that the purchasing of options provides no additional risk protection to crop insurers beyond what is provided by the SRA despite retention limits.
Judging and Judgment in Contemporary Asia: Editor’s Introduction to this Special Issue
Authors: Engel David M.
Published: October 2021

Although the figure of the wise judge may be a universal trope, respect is not automatically accorded every person who passes judgment on another. To be perceived as legitimate, judges must occupy an institutional status with the power to decide controverted cases and must have access to specialized or even sacred knowledge and moral authority. Historically, Asian judges could claim legitimacy through their connection to transcendent legal principles, such asdhammaordaoorshari’a. In contemporary Asia, however, conceptions of law and legal legitimacy have become pluralistic, contested, and contradictory. Judges may to some extent retain a connection to the sacred and the transcendent, yet that connection is no longer sufficient in itself to insulate their judgments—or their character—from criticism. How, then, can the “good judge” be distinguished from judges who fall short of the mark? In this Special Issue, five distinguished scholars explore the crisis of legitimation as it affects judging and judgment in Sri Lanka, India, China, Indonesia, and Thailand.
The Curious Case of Three Male Elders: Land Grabbing, Lawfare, and Intersectional Politics of Exclusion in Tanzania
Authors: Chung Youjin B.
Published: October 2021

In 2012, three male elders in Tanzania filed a lawsuit against the government and a foreign investor for trespassing, justifying the case as rightful resistance to land grabbing. Based on ethnographic research, however, Chung argues that their action is more appropriately understood as gendered lawfare; the plaintiffs drew on their multiple positions of privilege to exclude a diverse array of legitimate resource users, including their wives. Their lawfare was not only perverse in its design, but also in its effects. It increased the uncertainties surrounding the rights and status of local people and reinforced intersecting inequalities within the “local” itself.