bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Galectin-3 in The Diagnosis and Evaluation of Disease Activity in Rheumatoid Arthritis
Authors: Almurshedi Shihab Mahmood , Alasady Raad Abdulameer Alasady , Alsherees Hashim Ali , Almohana Ali M. , Aljayashi Kareem Gali , Almudhaffer Dhifaf  Hameed
Published: September 2023

Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects small joints, leading to joint inflammation, pain, and limited mobility. New biomarkers specific to RA could facilitate early diagnosis and treatment, while also enabling better monitoring of disease activity and treatment response.  By ELISA, galectin-3 (gal-3) level was measured in 133 patients with inflammatory arthritis to determine the diagnostic value of gal-3 in the diagnosis of RA and evaluate the disease activity. Serum gal-3 levels were significantly higher in RA patients compared to patients with other types of inflammatory arthritis. According to CDAI, DAS-28 ESR, and DAS-28 CRP, gal-3 showed positive correlations with disease activity scores. Galectin-3 at a cut-off value of ≥ 2.4 ng/ml, revealed 89% sensitivity, 91% specificity, and an AUC of 0.893. There was a significant correlation between gal-3 and the age of RA patients, while no significant correlations were observed with gender, BMI, and smoking index. Notably, gal-3 levels correlated significantly with CRP, RF titer, and ACPA levels. Therefore, gal-3 can be considered a valuable biomarker for the diagnosis of  RA and evaluating the disease activity.
Revitalisasi Filsafat Kebahagiaan Buya Hamka sebagai Respon terhadap Fenomena Mental Distress di indonesia
Authors: Bara Ariyandi Batu , Darmadi Darmadi , Hoir Hubul , Hatta Juparno
Published: September 2023

Manusia normal idealnya memiliki pemikiran bahwa hidup ini adalah mencari kebahagiaan. Namun fakta sosial di Indonesia masih menunjukkan bahwa manusia modern masih dilanda oleh mental distress. Karena itu, untuk mendapatkan kebahagiaan, seseorang harus berusaha untuk mengetahui hakikat kebahagiaan itu sendiri. Tulisan ini bertujuan untuk menguraikan tentang: (1) Hakikat kebahagiaan menurut pemikiran Hamka; (2) Unsur-unsur kebahagiaan dalam perspektif Hamka; dan (3) Relevansi konsep kebahagiaan menurut Hamka dalam konteks kekinian. Tulisan ini menggunakan pendekatan kualitatif dalam menggali datanya. Pendekatan analisis konten dipakai untuk menggali pemikiran Hamka tentang filsafat kebahagiaan. Data primer diambil dari buku Hamka berjudul: “Tasawuf Modern: Bahagia Itu Dekat dengan Kita, Ada di dalam Diri Kita.” Sedangkan data sekunder diambil dari literatur lainnya yang relevan. Hasil dari penelitian ini yaitu: (1) Hakikat kebahagiaan menurut pemikiran Hamka terbagi menjadi tiga tingkatan yaitu: kebahagiaan akhirat, kebahagiaan akal budi, dan kebahagiaan tubuh. (2) Unsur-unsur yang membentuk kebahagiaan manusia yaitu memiliki: akal yang sempurna, i’tikad yang bersih, keyakinan, iman, dan agama. (3) Pemikiran Hamka mengenai filosofi kebahagiaan masih sangat relevan dengan konteks kekinian untuk mengatasi mental distress di tengah masyarakat.

Kata kunci: Filsafat, Kebahagiaan, Hamka, Mental Distress.
Muhammad Bin Abdul Wahab
Authors: Solihin Muhamad , Winarto Winarto
Published: September 2023

Salafi merupakan gerakan pembaharu islam yang mengaku sebagai kelompok yang mengikuti ajaran islam murni seperti salafu al-sholih. Kaum ini disebut sebagai wahabi oleh kelompok lain, karena menisbatkan kelompok ini kepada pendirinya yaitu Muhammad bin Abdul Wahab. Tentunya antara pengikut dan pendiri sedikit banyak memiliki korelasi diantara keduanya dalam berbagai aspek. Tujuan penelitian ini akan meneliti bagaimana korelasi tersebut menggunakan penelitian kualitatif, terkhusus menggunakan intrumen kepustakaan dan observasi. Mulai dari ajarannya, sampai metode dakwahnya. Selanjutnya, data yang dikumpulkan akan dianalisis menggunakan pendekatan fenomenologi dan filosofis. Melihat penelitian sebelumnya yang membahas hanya tentang korelasi ajaran saja, dan belum sampai menyentuh ranah metode dakwah secara eksplisit. Maka, upaya mengkorelasikan sampai pada taraf metode dakwahnya mengemuka. Hasil penelitian ini menyimpulkan bahwa dakwah yang dilancarkan oleh gerakan salafi itu berkorelasi dengan doktrin pendirinya, yaitu menyerukan islam murni yang kembali kepada Al-Qur’an dan al-Sunnah. Tak hanya itu, metode dakwahnya pun sama, yaitu melalui sesuatu yang sangat berpengaruh di zamannya masing-masing. Jika Muhammad bin Abdul Wahhab melalui para pemimpin, maka gerakan salafi di Indonesia di zaman sekarang melalui media sosial yang dapat dilihat oleh banyak orang.
Kue Procot:
Authors: Soenjoto Wening Purbatin Palupi , Rohmah Nihayatur , Hasani Ismail
Published: September 2023

Abstrak:Pulau Jawa dibagi menjadi 3 bagian yaitu Jawa Tengah,Jawa Timur,Jawa Barat.Masing-masing daerah tetap memiliki perbedaan,dari bahasa,adat istiadat hingga tradisinya.Bagi masayarakat Jawa timur dan Jawa Tengah tidak asing dengan istilah mitoni dan bagi masyarakat Jawa Barat menyebut nujuh bulanan.Walau berbeda nama namun tetap memiliki makna yang sama yaitu selamatan bagi wanita hamil yang berusia 7 bulan. Diadakannya mitoni dengan tujuan agar calon ibu dan calon bayi mendapatkan keselamatan sejak dalam kandungan hingga tumbuh dewasa. Diadakannya mitoni dengan tujuan agar calon ibu dan calon bayi mendapatkan keselamatan sejak dalam kandungan hingga tumbuh dewasa. Proses ritual mitoni ditandai dengan siraman,air dari 7 sumur,bunga 7 rupa ,polo pendhem,kelapa cengkir dan ada kue bermana kue procot yang wajib ada dalam proses mitoni.Kue ini mempunyai makna agar sang ibu akan mudah saat melahirkan,bayinya lahir dengan mudah,Jika Makna dari kata procot artinya mudah keluar tanpa halangan dan selamat. Kue yangdikukus terbuat dari tepung beras,gula merah dan santan kelapa lalu dibungkus berbentuk contong dari daun nangka.Contong dibuat seperti corong namun tidak ada lubangnya. Kue procot memiliki tekstur lembut dan kenyal.Untuk bisa menghasilkan tekstur kue yang lembut dan kenyal harus memiliki keahlian khusus,biasanya para ibu yang sudah terbiasa membuatnya.Semakin lembut dan kenyal,dipercaya akan menjadi sugesti saat melahirkan dengan mudah tanpa halangan.Namun sayangnya,tradisi membuat kue procot ini kurang dikembangkan dan tidak diikuti banyak wanita Jawa karena dianggap sulit mengerjakannya.Walaupun kue procot berbahan sederhana namun membutuhkan ketrampilan untuk mendaptkan tekstur yang lembut dan kenyal karena melalui tekstur kue akan melambangkan proses kelahiran nantinya.Penelitian ini menggunakan metode kualitatif dengan pendekatan fenomologis dan menggunakan wawancara terbuka pada para responden berjenis kelamin wanita , bersuku Jawa dan sudah menikah. Terdiri dari 25 orang berusia 50-55 tahun,15 orang mewakili usia generasi milineal serta 15 orang mewakili generasi Z.Fenomena yang tampak sebagai refleksi dari realitas yang tidak dapat berdiri sendiri, karena memiliki makna yang memerlukan penafsiran yang lebih lanjut.

Kata kunci:tradisi,sugesti,mitos,kue procot.
THE ACCELERATION OF MASSIVE VACCINATION ACTIVITIES IN OVERCOME CREDIT CRUNCH DURING THE COVID-19 PANDEMIC (HUMAN RIGHTS PERSPECTIVE HUMAN AND MAQASHID SHARIA)
Authors: Wibowo Teguh Setiawan
Published: September 2023

Based on CNN Indonesia's economic growthIndonesia minus 2.2% in 2020 so that causes revenuesociety declines, corporate performance weakens due to depressed sales and production,as well as investments that are still not improving. In addition, on the supply side the risk of failurepay is very large so indirectly bad credit (credit crunch) as wellincrease. The firm level data method shows that during 2020, credit occurredcrunch caused by both demand and supply sides of credit. Actually Bank Indonesia already has a solution to overcome the credit crunch by dividingseveral subsectors into 4 quadrants of the subsectors that have the most resiliencestrong to sub-sectors that have the weakest resilience. But such a solutiononly temporary (temporary) and will not be able to overcome the problemcomprehensive credit crunch. Save the writer, the acceleration of massive vaccination activitiesis the only way that can be used to solve the problemcredit crunch. Even so, there are still many people who refusein human rights and religious arguments. Therefore, this research aims toproves that the credit crunch can only be overcome by accelerating activitiesvaccination, vaccination does not conflict with human rights values, andVaccination does not conflict with religious values, especially Islam and Religionin line with maqashid syari'ah.

Key Words:“Vaccination, Credit Crunch, Human Right, Maqashid Syari’ah”
THE SHARIA BANK STABILITY: HOW FINTECH AND FINANCIAL RATIO FIXED IT?
Authors: Az Zahra Ailsa Nabila , Miranti Titis
Published: September 2023

This study aims to see whether the stability of Islamic banks is sufficiently dependent on financial technology and several financial ratios. The research was conducted at Islamic banks in Indonesia and Malaysia. To get the research sample used, a purposive sampling technique. The research sample consisted of 14 Islamic banks and was observed from 2017 to 2021. The analytical method uses panel data regression. The research results show. Capital Adequacy Ratio, Non-Performing financing (NPF), Equity-to-Assets Ratio (EAR) and firm size significantly affect bank stability, while financial technology, Assets Turnover, and Cost to Income Ratio (CIR) have no significant effect. Bank stability is one of the determinants of the goodness of state finances, so it needs to be a concern. Banks can increase capital values and firm size, then maintain NPF and EAR values to keep bank financial stability. Even though several other factors are not significant, banks still need to maintain the stability of their value so that the impact does not get worse.
Penanaman Pendidikan Karakter Religius Melalui Lima Palembang Pada Anak Usia SD Sebagai Upaya Pencegahan “Lost Generation”
Authors: Wijaya Khairil Candra , Ihawana Al , Fatimah Siti , Jadiddah Ines Tasya
Published: September 2023

Penelitian ini bertujuan untuk (1) Untuk mengetahui Implementasi lima pelambang adat semende dalam menumbuhkan karater pada anak usia SD di desa batu surau kec semende darat tengah Kab Muara Enim (2) Untuk mengetahui faktor yang mempengaruhi penanaman pendidikan karakter melalui lima pelambang adat semende pada anak usia SD di Desa Batu Surau Kec. Semende Darat Tengah Kab. Muara Enim. Metode penelitian ini menggunakan metode kualitatif deksriptif teknik pengumpulan data penelitian ini adalah: observasi, wawancara, dokumentasi. Hasil penelitian ini menunjukan bahwa :(1) penanaman lima pelambang adat semende dalam menumbuhkan karakter religius pada anak usia SD Desa Batu Surau sebagai upaya pencegahan lost generation dilakukan dengan melalui tiga tahapan yaitu pendahuluan, inti, dan penutup, dengan adanya penanaman lima pelambang adat semende dapat menanamkan pendidikan karakter religius dan mencegah terjadinya lost generation. Faktor yang mempengaruhi penanaman pendidikan karakter religius di desa batu surau sebagai upaya pencegahan lost generation faktor pendukung dan dan pengahambat adalah (1) masih adanya Taman Pendidikan Alqur’an (TPA) yang aktip, penamaman nilai-nilai lima pelambang adat sebagai pedoman atau nasehat yang erat dalam keluarga,banyaknya anak SD yang melanjutkan ke pondok pesantren sedangkan faktor penghambat adalah: adanya HAM di sekolah, pengaruh sosial handphone, dan kurangnya dorongan orang tua kepada anak dalam belajar.
POLA PENGUPAHAN BURUH TANI KEBUN KACANG TANAH DI PEDESAAN
Authors: Sari Umi martika , Afriansyah Syafran , Lubis Ramiah
Published: September 2023

ABSTRAK
 
 Salah satunya pola pengupahan buruh tani kacang tanah di Desa Sungai Rotan Kecamatan Rantau Panjang Kabupaten Ogan Ilir, yaitu bekerja sebagai buruh penanam kacang tanah yang panen setiap tiga bulan sekali. Mulai bekerja dari pukul 07:00-12.00 WIB upah yang didapat dari pemilik kebun dengan memperoleh 3 Kg kacang tanah, maka upahnya Rp.20.000 setengah hari. Sedangkan pekerjaan lainnya seperti buruh tani sawah upahnya Rp.35.000, buruh bangunan upahnya Rp.100.000. Dilihat dari perbedaan pembayaran upah dari berbagai jenis pekerjaan yang ada di Desa Sungai rotan ini, upah buruh tani kacang tanah ini terlalu kecil untuk kebutuhan sehari-hari. Dengan rumusan masalah dalam skripsi ini yaitu: (1). Bagaimanakah Pola Pengupahan Buruh Tani Kacang Tanah di Desa Sungai rotan Kecamatan Rantau Panjang Kabupaten Ogan Ilir, (2). Bagaimanakah Relevansi Hukum Ekonomi Syariah Terhadap Pola Pengupahan Buruh Tani Kacang Tanah di Desa Sungai rotan Kecamatan Rantau Panjang Kabupaten Ogan Ilir. 
Metode penelitian ini adalah penelitian lapangan (Field Research), dan metode jenis data yang digunakan yaitu kualitatif. Populasi dalam penelitian ini yaitu pola pengupahan buruh tani kebun kacang tanah di Desa Sungai rotan dan sample yang digunakan berjumlah 8 orang. Teknik pengumpulan data observasi, wawancara dan dokumentasi. Data yang dikumpulkan kemudian di analisis secara deskriptif kualitatif. 
 Dari hasil penelitian dapat disimpulkan bahwa: (1). Pola pengupahan buruh tani di Desa Sungai rotan Kecamatan Rantau Panjang Kabuapten Ogan Ilir, berdasarkan perjanjian yang disepakti oleh pemilik kebun dan buruh tani tidak dilihat dari perjanjian secara tertulis melainkan secara lisan, dan sistem pengupahannya secara harian, mulai dari jam 07:00-12:00 WIB dengan upah Rp.20.000. Pembayaran upah diberikan diakhir pekan dengan memperhitungkan beberapa hari kerja yang dilakukan oleh buruh tani. (2). Relevansi hukum ekonomi syariah bahwa pola pengupahan yang di praktekkan oleh buruh tani di Desa Sungai rotan Kecamatan rantau panjang kabupaten ogan ilir, tidak menyalahi prinsip-prinsip hukum islam. Dan juga upah yang diberikan sesuai dengan kesepakatan yang dibuat dan juga sesuai dengan adat kebiasaan yang berlaku pada masyarakat setempat.
 
Kata Kunci: Hukum Ekonomi Syari’ah, Upah Buruh Tani.
MULTI AKAD PADA JASA WAJEK ONLINE KAYUAGUNG
Authors: Rahayu Sri , Harun Muhamad , Fauziah Fauziah
Published: September 2023

ABSTRAK
Wajek Online merupakan jasa transportasi online yang mengandung 2 akad yaitu qardh dan ijarah, yang mana terdapat hadis yang melarang penggabungan akad salaf (pinjaman) dan jual beli. Rumusan penelitian ini adalah: Bagaimana Proses Mekanisme Pemesanan, Tinjauan Hukum Ekonomi Syariah, dan Tinjauan Perspektif ‘Urf Pada Wajek Online Kayuagung ?, yang memiliki tujuan untuk mengetahui proses mekanisme pemesanan, mengetahui Tinjuan Hukum ekonomi Syriah, serta tinjauan perspektif ‘urf pada jasa Wajek Online Kayuagung.
Metode penelitian yang digunakan ialah pendekatan kualitatif, teknik pengumpulan data dengan cara wawancara, dokumentasi, dan observasi. Analisis yang digunakan adalah metode induktif yang menekankan pada pengamatan dahulu, kemudian menarik kesimpulan berdasarkan pengamatan
Kesimpulan penelitian pertama memesan Wajek Online dengan cara membuka aplikasi dan memilih nomor driver, kemudian memesan makanan dan mengkonfirmasi pembayaran. Yang kedua tinjauan hukum ekonomomi syariah termasuk dalam multi akad yang mujtami’ah dan diperbolehkan karena berdasarkan rukun dan syarat di masing-masing akad sudah terpenuhi. Ketiga Wajek Online termasuk dalam perspektif ‘úrf shahih karena Wajek Online adalah jasa layanan yang sering digunakan dan bermanfaat bagi masyarakat Kayuagung. Dan kegiatan ini merupakan kebiasaan yang baik serta tidak bertentangan dengan ajaran Al-Qur’an dan Sunnah Rasullullah.
 
Kata Kunci: Wajek Online Kayuagung, Multi Akad, Hukum Ekonomi Syariah, ‘Urf
Desain Didaktis Konsep Reaksi Reduksi Oksidasi
Authors: Khaerudin Rizky Brehnaputrifajar , Supriatna Asep , Hendayana Sumar , Herwantono Herwantono
Published: September 2023

The lack of didactic anticipation as reflected in lesson plans can have an impact on the less optimal learning process for each student so that learning obstacles arise. One effort to overcome this is to design learning through didactic design. This study aims to develop a didactic design in reducing learning obstacles in the concept of redox reactions. The method used in this research is a qualitative research method. The research design used is Didactical Design Research (DDR). Data collection techniques used are tests, observations, interviews and documentation. Respondents in this study were 30 students of the UPI Pilot Laboratory High School in class XI IPA 2 and 28 students in class X. Based on the results of the study, it was found that the didactic design developed in the form of Chapter Design and Lesson Design included providing an understanding of concepts through the provision of phenomena followed by experiments or demonstrations in general, which ran smoothly. The existence of Chapter Design and Lesson Design components aims to make students obtain the material. The other goal is to make it easier for teachers to achieve better educational goals by bringing out predictions of student responses and prepared teacher anticipation. This didactical design can reduce learning barriers and can improve students' abilities. It can be concluded that the didactic design of the concept of oxidation-reduction reactions is effective as an alternative teaching material used in the learning process.
Gerakan Literasi Sekolah dalam Meningkatkan Minat Baca
Authors: Mirnawati Mirnawati
Published: September 2023

This study aims to explain the literacy movement and its impact on increasing students' interest in reading at MAN I Prabumulih. The School Literacy Movement in increasing students' interest in reading at MAN 1 Prabumulih uses a qualitative research approach and type. That is, research with the aim of describing and analyzing every event, event or phenomenon related to the problem that the researcher discusses. The results of the School Literacy Movement (GLS) research at MAN I Prabumulih in increasing interest in reading include through the habit of reading between before starting lessons (tadarus) for students who are unable to go to the library, muhaarah, memorizing surahs and hadiths, tadarus every Friday at the school mosque. The impact of the School Literacy Movement (GLS) at MAN I Prabumulih is that there are positive things that schools get through this program. In addition to students' interest in reading through active visits to the library, they are also enthusiastic about participating in school madding, placing several collections of books that can be exchanged with other students in the class reading corner, and concrete evidence is the success of students in winning competitions on literacy outside of school. Supporting and Inhibiting Factors for the School Literacy Movement (GLS) in Increasing Students' Interest in Reading at MAN I Prabumulih include reading facilities, funds, student motivation and interest, reading resources, and a variety of reading books.
Okul Öncesi Dönem Çocuklarında Dijital Oyun Bağımlılık Eğilimi ve Problem Davranışlar
Authors: BAĞATARHAN Tuba
Published: September 2023

Bu araştırmanın amacı, okul öncesi dönem çocuklarının dijital oyun bağımlılık eğilimleri ile problemli davranışları arasındaki ilişkilerin incelenmesidir. Araştırmada ilişkisel tarama modeli kullanılmıştır. Araştırmanın örneklemi Aydın il merkezindeki beş anaokulunda eğitime devam eden 4-6 yaş grubu 351 (167 kız ve 184 erkek) okul öncesi dönem çocuğundan oluşmaktadır. Araştırma verileri 2022-2023 eğitim öğretim yılında toplanmıştır. Araştırmada veri toplama araçları olarak Dijital Oyun Bağımlılık Eğilimi Ölçeği, Problem Davranış Ölçeği ve Kişisel Bilgi Formu kullanılmıştır. Verilerin analizinde frekans, yüzde, aritmetik ortalama, Pearson momentler çarpımı korelasyonu ve basit doğrusal regresyon analizi kullanılmıştır. Pearson momentler çarpımı korelasyon analizi sonuçlarına göre, okul öncesi dönem çocuklarında dijital oyun bağımlılık eğilimi ile problem davranışlar ve alt boyutları olan dışa yönelim davranışları, içe yönelim davranışları, antisosyal davranışlar ve ben merkezci davranışlar arasında pozitif yönde anlamlı bir ilişki olduğu tespit edilmiştir. Basit doğrusal regresyon analizi sonuçlarına göre okul öncesi dönem çocuklarında dijital oyun bağımlılık eğiliminin genel olarak problemli davranışları, dışa yönelim davranışlarını, içe yönelim davranışlarını, antisosyal davranışları ve ben merkezci davranışları pozitif yönde anlamlı düzeyde yordadığı belirlenmiştir. Araştırma bulguları, okul öncesi dönem çocuklarının dijital bağımlılık eğilimleri arttıkça problemli davranışları çerçevesinde ele alınan dışa yönelim davranışları, içe yönelim davranışları, antisosyal davranışları ve ben merkezci davranışları artış göstermektedir. Araştırma bulguları çerçevesinde, okul öncesi dönemde problemli davranışların önlenmesinde dijital oyunların içeriği ve oyun oynama süresi konusunda ebeveyn rehberliğinin önemi vurgulanmıştır.
Anti-Governemnt Extremism in Australia: Understanding the Australian Anti-Lockdown Freedom Movement as a Complex Anti-Government Social Movement
Authors: Khalil Lydiia , Roose Joshua
Published: September 2023

This article aims to explore the emergence and consolidation of various actors and sympathisers into the Australian ‘anti-lockdown’ freedom movement, a diverse, hybrid anti-government movement that emerged during the public health response to the COVID-19 pandemic. Through a qualitative longitudinal analysis of data from the online posts of a prominent branch of the anti-lockdown freedom movement, we identify the movement’s core narratives, motivations, and forms of action, revealing how this social movement developed into a complex form of anti-government extremist movement that combines and conflates anti-institutional, anti-elite sentiments, and anti-government attitudes and beliefs through conspiratorial narratives. Drawing upon interrelated strands of social movement theory and the broader body of research on conspiracy theories and the effects of the COVID-19 pandemic on radicalisation to extremism, we offer a conceptual framework to understand the movement’s emergence, consolidation, and development. This study furthers our understanding of how conspiracies and disinformation can be utilised and fed into anti-government extremism during times of crisis and emergency.
Endovascular embolization of persistent liver injuries not responding to conservative management: a narrative review
Authors: Roh Simon
Published: September 2023

Trauma remains a significant healthcare burden, causing over five million yearly fatalities. Notably, the liver is a frequently injured solid organ in abdominal trauma, especially in patients under 40 years. It becomes even more critical given that uncontrolled hemorrhage linked to liver trauma can have mortality rates ranging from 10% to 50%. Liver injuries, mainly resulting from blunt trauma such as motor vehicle accidents, are traditionally classified using the American Association for the Surgery of Trauma grading scale. However, recent developments have introduced the World Society of Emergency Surgery classification, which considers the patient's physiological status. The diagnostic approach often involves multiphase computed tomography (CT). Still, newer methods like split-bolus single-pass CT and contrast-enhanced ultrasound (CEUS) aim to reduce radiation exposure. Concerning management, nonoperative strategies have emerged as the gold standard, especially for hemodynamically stable patients. Incorporating angiography with embolization has also been beneficial, with success rates reported between 80% and 97%. However, it is essential to identify the specific source of bleeding for effective embolization. Given the severity of liver trauma and its potential complications, innovations in diagnostic and therapeutic approaches have been pivotal. While CT remains a primary diagnostic tool, methods like CEUS offer safer alternatives. Moreover, nonoperative management, especially when combined with angiography and embolization, has demonstrated notable success. Still, the healthcare community must remain vigilant to complications and continuously seek improvements in trauma care.
Coleta de amostras sanguíneas no cordão umbilical para realização de exames laboratoriais: uma revisão da literatura
Authors: Quintão Júnia Gonçalves de Almeida , Marchito Isabelle Raymundo , Pazini Natany de Oliveira , Silva Karla Rona da
Published: September 2023

Objetivo: apresentar as evidências científicas sobre as orientações para a coleta de sangue de cordão umbilical para realização de exame laboratorial de recém-nascidos, publicados no período de 2011 a 2021. Metodologia: revisão integrativa da literatura com utilização do Prefered Reporting Itens for Systematic Reviews and Meta-Analyses. Bases de dados utilizadas: Biblioteca Virtual de Saúde, LILACS, MEDLINE, PUBMED, CINAHL, UpToDate e Cochrane Library. Resultados: analisados 12 estudos, sendo 1 artigo de revisão, revelando positividade em coletar amostras no sangue de cordão umbilical; e 1 estudo de caso, com descrição dos benefícios dessa coleta. Os outros 10 trabalhos foram estudos prospectivos, caso-controle. Em 7 estudos foi comparada a qualidade dos exames laboratoriais obtidos em sangue de cordão umbilical e diretamente nos recém-nascidos, na avaliação de sepses, com resultados positivos; e nos outros 3, observaram desfechos favoráveis na redução das transfusões de sangue quando coletadas no cordão umbilical ao se comparar a coleta direta, com melhores índices hematológicos. Conclusões: Os achados apoiam a viabilidade e precisão do sangue umbilical para coleta de exames laboratoriais admissionais. Isso reduz a perda na flebotomia e permite coletar maior volume sanguíneo. Há aumento da sensibilidade para hemocultura quando as equipes coletadoras são treinadas para esse fim.
Mechanical, durability and solar reflectance properties of colored self‒compacting concrete
Authors: Yıldızel Sadık Alper
Published: September 2023

Urbanized areas are known to have significantly higher temperatures than rural areas. The Urban Heat Island (UHI) effect is caused by surfaces such as asphalt, buildings, and other heat-absorbing surfaces that store more heat than natural vegetation. Sunlight reflecting properties of building materials are improved with different applications. The present study investigates the mechanical, durability and solar reflectance properties of the colored self-compacting concrete. SCCs containing yellow, green, and black pigments were produced and evaluated. The fresh properties were determined with the slump, L-Box and V-funnel tests. Furthermore, compressive strength, solar reflectance and magnesium sulfate resistance tests were conducted. Yellow pigment added SCC showed a great potential (with the albedo of 0.42) in terms of solar reflectance and decreasing the contribution to the urban heat island effect.
Effect of dosage on the mechanical properties of epscrete
Authors: Canbaz Mehmet , Günaltılı Emir , Albayrak Uğur
Published: September 2023

Epscrete, which is made by employing aggregate made of expanded polystyrene beads, is often used to make wall panels, block components, and insulating plates. For these products to have greater mechanical qualities, 400, 600, and 800 dose epscrete specimens were made in this research, which also considered the influence of cement quantity. The water-cement ratio was considered to be 0.5. In addition to the reference specimens, the same manufacture was carried out utilizing a 1% plasticizer admixture. Specimens were subjected to unit weight, ultrasonic pulse, water absorption, bending, and comprehension tests 7 and 28 days after production. The effects of the dose and plasticizer rate on the physical and mechanical properties of early and ultimate epscrete specimens were determined according to the unit weight, ultrasonic pulse velocity, water absorption rates, bending and compressive strength values. Increasing the dosage increased the ultrasonic pulse velocity, reduced water absorption by reducing the amount of gap and reduced water absorption, and increased compressive strength by approximately 65 % and bending strength by about 60 %. It has been determined that the mechanical and physical properties of epscrete are affected by dose and mixture ratios. By increasing the dosage, it has been seen that carrier light carrier blocks can be obtained.
Aplikasi Formula Pupuk Granul N-slow release Berpelindung Polimer terhadap Sifat Kimia Inseptisols dan Pertumbuhan Bawang Merah Bauji
Authors: Palupi Murti Rahmi , Widyasunu Purwandaru
Published: September 2023

Nitrogen merupakan unsur hara esensial bagi tanaman, namun keberadaannya mudah hilang karena pencucian dan penguapan. Oleh karena itu usaha untuk mengurangi kehilangan nitrogen melalui pembuatan formulasi pupuk lepas lambat untuk meningkatkan efisiensi N. Penelitian ini bertujuan untuk mengetahui: (i) pengaruh empat formula pada pupuk N lepas lambat terhadap beberapa sifat kimia Inseptisols sawah; (ii) pengaruh empat formula pupuk N lepas lambat terhadap pertumbuhan dan hasil tanaman bawang merah varietas Bauji. Penelitian ini dilaksanakan pada bulan Desember 2019 hingga Agustus 2020 di lahan sawah yang bertempat di Desa Purwosari, Kecamatan Baturraden, Banyumas, Jawa Tengah serta di Laboratorium Tanah Fakultas Pertanian. Penelitian berupa percobaan di lahan sawah dengan RAKL non-faktorial dengan lima perlakuan yang diulang sebanyak lima kali. Formula pada masing-masing perlakuan meliputi: F0 = N-P-K (Urea, TSP, dan KCl) , F1 = 70% Urea + 6% kitosan + 24% bahan humat, F2 = 70% Urea + 10% Azolla microphylla + 10% gondorukem + 10% bahan humat, F3 = 60% Urea + 10% Azolla microphylla + 10% gondorukem + 10% bahan humat + 10% montmorilonit, dan F4 = 56% Urea + 24% zeolit + 3% bahan humat + 11% tepung tapioka + 6% gondorukem. Variabel yang diamati antara lain tinggi tanaman, jumlah daun, jumlah anakan, bobot tanaman segar, dan bobot umbi segar, pH H2O, daya hantar listrik (DHL), dan N-Total tanah. Hasil penelitian menunjukan bahwa formula F3 dapat meningkatkan bobot tanaman segar sebesar 29,29% dan bobot umbi segar sebesar 29,68% dibanding kontrol. Perlakuan formula F4 memiliki pelepasan pupuk yang kurang stabil sehingga penyediaan unsur hara N untuk tanaman kurang optimal.
Pengaruh Aplikasi Media Arang Sekam dan Pupuk Organik Cair terhadap Hasil Tanaman Pakcoy (Brassica rapa L.)
Authors: Widarawati Rosi , Astriani Nanda , Mujiono Mujiono
Published: September 2023

Penelitian  bertujuan untuk mengetahui pengaruh media tanam arang sekam dan pupuk organik cair (SO-Kontan Fert) terhadap hasil tanaman pakcoy. Penelitian dilaksanakan pada Januari sampai Maret 2021 di screen house Desa Melung, Kecamatan Baturraden, Kabupaten Banyumas, Jawa Tengah dan Laboratorium Agronomi dan Hortikultura Fakultas Pertanian Universitas Jenderal Soedirman. Penelitian dengan percobaan faktorial dalam Rancangan Acak Kelompok Lengkap dengan 3 ulangan sebagai blok.  Faktor pertama yaitu tanpa arang sekam, tanah + arang sekam (1:1), tanah (2:1), tanah + arang sekam (3:1). Faktor kedua konsentrasi  POC SO-Kontan Fert yaitu, 0 , 5, 10 dan 15 ml/l. Hasil penelitian menunjukkan pemberian arang sekam pada perbandingan 3 : 1 meningkatkan bobot tajuk kering. Perbandingan 2 : 1 meningkatkan bobot tanaman segar, bobot tanaman kering dan bobot tajuk segar. Pemberian pupuk organik cair (SO-Kontan Fert) konsentrasi 5 ml/l meningkatkan panjang akar.
From Darwinism to the Modern Age: How Evolutionary Paradigms Shape the Understanding of Host-Virus Coevolutionary Processes – A Review
Authors: Feronato Sofia Galvão , Silveira Guilherme Ferreira
Published: September 2023

Synthesizing evolution in the post-Darwinan era has been a very challenging endeavor, both because of the great number of perspectives regarding the same natural phenomena and because of the growing technology involving mapping the origin of novelties and selection of biological variation that surpass Darwin’s original proposal of evolution by means of natural selection. Since 1859 a lot has changed, and many have presented new perspectives on evolution; either dismissing, correcting or incorporating Darwin’s ideas. This review aims to approach these different theories focusing on virus host interactions and descriptions of host-switching events in 3 different viral lineages, as well as their implications on the understanding of host-switching phenomena itself.
Effect of Terminal Substituents of 2-Aminobenzimidazoles on Non-Covalent Molecular Interactions in Their Transition Metal Coordination Compounds. Evaluation of Their Biological Activity
Authors: Barba-Behrens Norah , Colorado-Solís David , Castro-Ramírez Rodrigo , Sánchez-Bartéz Francisco , Gracia-Mora Isabel
Published: September 2023

There were designed and synthesized two new sulfone 2-aminobenzimidazole derivatives. Coordination compounds were obtained with nickel(II), copper(II), zinc(II), cadmium(II) and mercury(II) and these novel ligands. There were fully characterized by spectroscopic and analytical techniques. Single crystal X-ray structural analysis was performed on order to study the relevant intra and inter non-covalent interactions, mainly H...π, lone pair·...π, π...π, highlighting the difference between the ethyl and phenyl groups in such interactions. Dimeric and trimeric supramolecular syntons were found for some of these compounds. Their biological activity was investigated, being the copper(II) compounds with the sulfone phenyl derivative the most active.
In Vitro Evaluation of Madio Pro+ Multipurpose Disinfectant Reveals Its Efficacy against Salmonella typhimurium Biofilm
Authors: Yaacob Mohamad Fakhri , Nur Anisah Johari , Nur Alya Athirah Kamaruzzaman , Man Che Amira Che , Amran Siti Sarah
Published: September 2023

Biofilms are complex communities of microorganisms that adhere to surfaces and develop a protective matrix. The colonization of devices in the food and health care industries by microbial biofilms poses numerous risks. Existing antimicrobial agents often fail to penetrate the biofilm matrix, allowing the pathogen to grow and persist. The objective of this study was to evaluate the impact of MADIO PRO+ multipurpose disinfectant on Salmonella Typhimurium biofilm using crystal violet assay and FTIR spectroscopy. Results demonstrated that MADIO PRO+ multipurpose disinfectant significantly (p<0.05) inhibited biomass of S. Typhimurium biofilm and altered the structure of S. Typhimurium biofilm. In conclusion, MADIO PRO+ multipurpose disinfectant offers an advantage in biofilm control strategy. This discovery could help the food and health care industries to plan better microbial intervention strategies.
Issues of Microplastics Pollution in Tap and Drinking Water Sources in Thailand and Health Impacts
Authors: Jinda Kesirine , Koottatep Thammarat , Liamlaem Warunsak , Chaiwong Chawalit , Pussayanavin Tatchai , Polprasert Chongrak
Published: September 2023

The growing population with changing consumption patterns in developing countries is causing significant challenges with regards to solid waste management. Plastic wastes are particularly problematic, with single-use plastics leaking into the environment, including the marine environment, at an unprecedented rate. Approximately 80 percent of ocean plastics come from land-based sources or about 8 million tons are dumped into the ocean every year. Thailand was identified as one of the top 10 countries ranked by mass of mismanaged plastic wastes, with more than 60,000 tons per year entering the ocean through multiple outlets, including rivers. In the environment, plastic wastes can be degraded into small sizes (less than 5 mm), called microplastics (MPs), which could contaminate the ecosystems and the food chain, including foodstuffs and water supply. Tap water samples collected from a water supply treatment plant and Academic Institutions 1 and 2 in central Thailand were found to contain MPs about 304 ±90, 270 ±109 and 386 ±102 particles/L, respectively. In addition, MPs concentrations of 211 ±70 and 122 ±60 particles/L were also found in drinking water samples collected from commercial bottled water and membrane filtration water, respectively. The MPs sizes of 0-50 µm were most abundant in both the tap and drinking water samples whose shapes were mainly fragments and fiber. These data indicated potential health risks to the people who consume these water sources, and recommendations for health impacts minimization were proposed.
Random Number Generators: Principles and Applications
Authors: Bikos Anastasios , Nastou Panayiotis E. , Petroudis Georgios , Stamatiou Yannis
Published: September 2023

this paper we present approaches for generating random numbers along with potential applications. Rather than trying to provide extensive coverage of several techniques or algorithms that have appeared in the scientific literature, we focus on some representative approaches presenting their workings and properties in detail. Our goal is to delineate their strengths and weaknesses as well as their potential application domains so as the reader can judge what would be the best approach
for the application in hand, possibly a combination of the available approaches. For instance, a physical source of randomness can be used for the initial seed, then suitable preprocessing can enhance its randomness and then the output of the preprocessing can feed different types of generators, e.g. a linear congruential generator, a cryptographically secure one and one based on the combination of one way hash functions and shared key cryptoalgorithms in various modes of operation. Then, if desired, the outputs of the different generators can be combined giving the final random sequence. Moreover, we present a set of practical randomness tests which can be applied on the outputs of random number
generators in order to assess their randomness characteristics. In order to demonstrate the importance of unpredictable random sequences, we present an application of cryptographically secure generators in domains where unpredictability is one of the major requirements, i.e. eLotteries and cryptographic key generation.
Magnetostriction of Amorphous Magnetic Microwires: Role of Local Atomic Environment and Internal Stresses Relaxation
Authors: Zhukova Valentina , García-Gómez Alfonso , Gonzalez Alvaro , Churyukanova Margarita , Kaloshkin Sergey D. , Corte-Leon Paula , Ipatov Mihail , Olivera Jesus , Zhukov Arcady
Published: September 2023

We studied the magnetostriction coefficients, λs, Curie temperature, Tc, and their dependence on annealing conditions in Fe47Ni27Si11B13C2 and Co67Fe3,9Ni1,5B11,5Si14,5Mo1,6 amorphous glass-coated microwires with rather different character of hysteresis loops. A positive λs≈20x10-6is observed in as-prepared Fe47Ni27Si11B13C2, while low and negative λs ≈-0.3x10-6 is ob-tained for Co67Fe3,9Ni1,5B11,5Si14,5Mo1,6 microwire. Annealing affects the magnetostriction coeffi-cients and Curie temperatures, Tc, of both Fe47Ni27Si11B13C2 and Co67Fe3,9Ni1,5B11,5Si14,5Mo1,6 glass-coated microwires in a similar way. Observed dependencies of hysteresis loops, λs and Tc on annealing conditions are discussed in terms of superposition of internal stresses relaxation and structural relaxation of studied microwires. We observed linear λs dependence on applied stress, σ, in both studied microwires. A decrease with applied stress is observed for Co-rich mi-crowires with negative magnetostriction coefficient. In contrast, a linear increase of the magne-tostriction coefficient with applied stress is observed for Fe-Ni- rich microwires with positive magnetostriction coefficient. Observed results are discussed in terms of influence of internal stresses and short range atomic rearrangements induced by annealing on hysteresis loops, magnetostriction coefficients and Curie temperatures of studied microwires.
Evaluation of Drug-Induced Dysphagia Profile Using a Japanese Real-World Database: A Pharmacovigilance Study
Authors: Kose Eiji , Kawashima Mizuki , Yasuno Nobuhiro
Published: September 2023

Background: no reports have examined the profile of drug-induced dysphagia in detail. The goal of this study was to investigate if there are any differences in the profiles of drug-induced dysphagia. Methods: This study used the Japanese Adverse Drug Event Report (JADER) database. Further, reported odds ratios (RORs) were used to analyze data on adverse drug events from 2004 to 2021. The top ten drugs with the most drug-induced dysphagia occurrences were used as target drugs. The association between RORs and drug-induced dysphagia caused by the target drugs was evaluated, and the age distribution and time of onset of drug-induced dysphagia for each drug were compared. RORs were the primary endpoint. Moreover, age and time of onset of drug-induced dysphagia were secondary outcomes. Results: In total, 756,965 reports were analyzed. All the target drugs were associated with drug-induced dysphagia. Among them, cevimeline was a novel finding, as no dysphagia was observed during the clinical trial. For most drugs, the onset of drug-induced dysphagia was occurring within approximately 25 days of administration. However, even after long-term use, paroxetine and milnacipran were associated with drug-induced dysphagia. Conclusion: The onset profile of drug-induced dysphagia may differ from one drug to the next.
Aminocyclopropenium as a new class of hydrogen bonding catalyst in Friedel–Crafts alkylation
Authors: Ma Xuesuo , Xu Jiaxi , Liu Jingjing , He Jun , Chang Tong , Yang Qingbiao , Li Ning , Qian Dong , Li Zhenjiang
Published: September 2023

H-bonding, including H-bond donor (HBD) with electron-rich part of a substrate and H-bond acceptor (HBA) with electron-deficient part of a substrate, has achieved massive success. Faster transformation often correlates with more donicity of HBD. Besides the positive charge are employed to enhance the donicity of HBD, the electron withdrawing groups become a dissimilar approach for increasing the donicity of HBD. We describe newly designed H-bond donor catalysts, tris(monoalkylamino)cyclopropenium, implemented by vicinal positive charged on the cyclopropenium core. The counter anion became potential HBA to activate the electron-deficient part of a substrate. The tris(phenylamino)cyclopropenium chloride (TPAC·Cl) as a representative catalyst was applied in Friedel–Crafts alkylation of indoles with nitroalkenes. X-ray analyses of a single crystal of TPAC·Cl described the 3D architecture and the delocalized cationic charge in the solid state. Unit formal positive charge turned N–H moieties into H-bond donor (HBD) and the counter chloride anion exhibited potential H-bond acceptor (HBA). The HBD and HBA displayed cooperative organocatalysis in Friedel–Crafts alkylation of indoles with nitroalkenes. A new class of hydrogen bonding catalysis and working mechanism were proposed.
Valorization of Prickly Pear Peel Residues (Opuntia ficus-indica) Using of Solid-State Fermentation to Accumulation of Tannins
Authors: Coronado Contreras Sergio Arturo , Ruelas Chacón Xochitl , Reyes Acosta Yadira Karina , Dávila Medina Miriam Desirée , Ascacio Valdés Juan A. , Sepúlveda Leonardo
Published: September 2023

The Opuntia ficus-indica (OFI) prickly pear peel, is a residue product and was used as a substrate in solid-state fermentation (SSF) to obtain bioactive compounds of interest due to its antimicrobial and antioxidant activity. A Box Hunter & Hunter design to evaluate the independent factors was used. These factors were temperature (°C), inoculum (spores/g), humidity (%), pH, NaNO3 (g/L), MgSO4 (g/L), KCl (g/L) and KH2PO4 (g/L). The response factors were hydrolyzable and condensed tannins amount. In addition, the fermentation extracts the antioxidant and antimicrobial activity were evaluated. The results showed that the humidity (%), inoculum (spores/g) and temperature (°C) affect the release of hydrolyzable and condensed tannins. The treatments 13 and 16 were the best to accumulate condensed (43 mg/g) and hydrolyzable tannins (3.8 mg/g) respectively. Besides, the fermented extracts showed a higher antioxidant activity compared than the unfermented peel extracts, as well as a high inhibition versus E. coli, Alternaria sp. and Botrytis spp. The use of the fermentation process is a good alternative for the recovery of waste and the accumulation of bioactive molecules with potential industrial application.
Fuel Mapping Generation Using Remote Sensing: A CNN-Based Approach
Authors: Carbone Andrea , Spiller Dario , Laneve Giovanni
Published: September 2023

Accurate fuel mapping plays a crucial role in fire detection and management strategies. This paper presents a method for discriminating between wildfire fuel types by exploiting together remote sensing data and Convolutional Neural Networks (CNN). Specially, a CNN-based classification approach that leverages Sentinel-2 imagery is exploited to accurately classify fuel types into seven preliminary main classes (conifers, broadleaf, shrubs, grass, bare soil, urban areas, and water bodies) with an high accuracy of 0.99$\%$. To further refine the fuel mapping results, subclasses were generated from the seven principals by using biomass and bioclimatic maps. These additional maps provide complementary information about vegetation density and climatic conditions, respectively. By incorporating this information, we align our fuel type classification with the widely used Scott/Burgan fuel classification system. This refinement step allows for a more detailed and comprehensive assessment of fuel types, enhancing the accuracy and effectiveness of fire management efforts, which can be utilized by fire management agencies, policymakers, and researchers for improved fire behavior prediction and mitigation practices. The proposed approach presents a valuable tool for enhancing fire management, contributing to more effective wildfire prevention and mitigation efforts.
Natural Polymer-Based Hydrogels: From Polymer to Biomedical Application
Authors: Zhao Lingling , Zhang Jiaying , Liang Hongze , Chen Xianwu , Tan Hui
Published: September 2023

Hydrogels prepared from natural polymer have attracted extensive attentions in biomedical fields such as drug delivery, wound healing, and regenerative medicine due to their good biocompatibility, degradability and flexibility. This review outlines the commonly used natural polymer in hydrogel preparation, including cellulose, chitosan, collagen/gelatin, alginate, hyaluronic acid and starch. The polymeric structure and process/synthesis of natural polymers are illustrated, and natural polymer-based hydrogels including the hydrogel formation and properties are elaborated. Subsequently, the biomedical application of hydrogels based on natural polymer in drug delivery, tissue regeneration, wound healing and other biomedical field is summarized. Finally, the future perspectives of natural polymers and hydrogels based on them are discussed. For natural polymer, novel technologies such as enzymatic and biological methods are developed to improve the structural properties and the development of new natural based polymers or natural polymer derivatives with high performance is still very important and challenging. For natural polymer-based hydrogels, novel hydrogel materials, like double-network hydrogel, multifunctional composite hydrogels and hydrogel microrobots are designed to meet the advanced requirements in biomedical application, and new strategies such as dual-crosslinking, microfluidic chip, micropatterning and 3D/4D bioprinting, have been explored to fabricate advanced hydrogel materials with designed properties for biomedical application. Overall, natural polymeric hydrogels have attracted increasing interests in biomedical application, and the development of novel natural polymer-based materials and new strategies/methods for hydrogel fabrication is badly desirable and still challenging.