bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of silver diamine fluoride on the microleakage of glass ionomer restoration in primary teeth at different time intervals
Authors: Zubair Jasim Mais , Saleem Khalaf Muna
Published: August 2023

Silver diamine fluoride (SDF) has shown effectiveness in hardening tooth structure and killing bacteria. Therefore, it can be used to prevent and arrest dental caries. Riva Star (SDF) treatment alone will stop cavities but will not reverse the cavitation. The Silver Modified Atraumatic Procedure, often known as Smart, is the optimum technique for regaining the tooth's structure and function. Glass ionomer was introduced in (1972) as a new material that has become one of the most widely used materials in restorative dentistry. By releasing fluoride ions, this material has a therapeutic impact on the surrounding tooth structure. Microleakage is the ingress of bacteria, its byproducts, toxins, chemicals, oral fluids, and ions between the margins of the restoration and the cavity walls. Dental restoration lifetime is significantly influenced by microleakage at the toothrestoration contact. Material and method: In this study, we used 32 primary molars, class V cavities prepared on the buccal surface of all teeth. The teeth were divided into 2 groups: Group 1: 16 teeth treated with 38%SDF 8 of them restored directly with GIC filling and the other 8 restored after 14 days; Group 2: 16 teeth as control group left untreated with 38% SDF,8 teeth restored directly and 8 restored after 14 days. Samples were thermocycled, immersed in 2% methylene blue and then sectioned in a buccolingual direction. Dye penetration was measured with a digital camera connected to a stereo microscope. Result: results of this study showed a significant difference in microleakage between two-time intervals in which microleakage in GIC filling decreased at 14-day intervals than that of first-day interval in the experimental group, while in the control group, microleakage at 14 days intervals was higher than first-day interval, but it was not significant. Conclusion: Pretreatment of the primary teeth with SDF can decrease the microleakage of GIC restoration. If placed after 14 days, the microleakage would be lesser than that if the restoration was placed directly after SDF treatment. Therefore, it is recommended that SDF treatment be done, followed by a permanent restoration after 14 days, so the null hypothesis cannot be accepted. Keywords: Microleakage, Silver diamine fluoride, Glass ionomer filling, noninvasive dentistry
Evaluation of the Activity of some Plant Extracts and Malathion on
the Control of Callosobruchus maculatus
Authors: Jafar Teaimah Sadeq , Saleh Al-Hadlag Kadhim , Abd Ali Hlif Nasir
Published: August 2023

This study aimed to evaluate the efficacy of some plant extracts on the
control of callosobruchus maculatus.The plant extracts were Cuminum cyminum
seeds, Nerium oleander leaves, and Conocarpus erotica leaves at three concentrations: 0.5, 1, and 2% compared to the pesticide malathion 1.25ml. l-1 against
the southern bean insect Callosobruchus maculatus. Results showed that the ethanolic Conocarpus erotica leaves extract 2% achieved the highest mortality percentages to eggs, larvae and pupae by the values 12.86, 77.14, and 17.12 %,
compared to malathion, 77.7, 95.3, 70.36 % respectively, followed by ethanolic
Nerium oleander leaves extract 2%. In contrast, the aqueous and ethanolic extracts of Cuminum cyminum seeds performed the lowest effects. Repellent activities of Conocarpus erotica leaves and Nerium oleander leaves extracts gave a
good and higher effect, especially with the highest concentration, 2%, and when
extracted by ethanol. These extracts could be recommended in integrated pest
management programs to protect cowpea seeds against Callosobruchus maculatus.
Keywords:- Plant extracts, Mortality, Repellency effect, Callosobruchus maculatus.
Effect of Spraying with Micro-Elements, Gibberellic Acid and Salicylic Acid on Some Yield Traits of Date Palm CV. Khastawi.
Authors: A. Jubair Nafea. , F. Z. Al-Dulaimy Ahmed
Published: August 2023

The study was conducted in one of the private palm orchards in the
Euphrates district on date palm trees (CV. Khastawi) aged 30 years to find out
the response of the date palm cultivar Khastawi to spraying with micro-elements
at concentrations (0, 1 g L-1
) and symbolized by (M0 and M1), and spraying with
gibberellic acid at concentrations (0, 100, 200 mg L-1
) and symbolized by (G0,
G1, and G2) respectively, and spraying with salicylic acid in concentrations (0,
100, 200 mg L-1
) and symbols symbolized by (S0, S1, S2) respectively. 54 trees
were selected as homogeneous as possible, and the number of fronds for palms
and fruit clusters was unified. All service operations of the orchard were carried
out similarly to adding animal manure, pruning, pollination, watering, pest control and other service operations for all experimental units. The results showed
that spraying with microelements at a concentration (M1) significantly affected
all studied traits except for the non-reducing sugar content of the fruits. It
amounted to (10.76 g, 15.63 kg cluster-1
, 125.03 kg palm-1
, 69.37%, 33.78%,
53.61%) this is for the traits (fruit weight, cluster weight, yield, total soluble solids, reducing sugars, total sugars), respectively. Also, spraying with gibberellin
showed a significant effect on the traits (fruit weight, cluster weight, yield, total
soluble solids), and the treatment (G2) gave the highest values for the traits (fruit
weight, cluster weight, yield), with 10.53 g, 15.46 kg cluster-1
, 123.71 kg palm-1
,
respectively. At the same time, treatment (G0) achieved the highest value of total
soluble solids (67.50%).
On the other hand, salicylic spraying did not significantly affect the studied traits,
except total soluble solids and reducing sugars. The concentration (S2) showed
the best values for the two traits, with 67.59% and 34.36%, respectively. The
two-way interactions between the study factors showed a significant effect that
varied according to the type of trait and the interaction factors. Whereas the
three-way interaction between the study factors reached the level of significance
in all the studied traits. The most significant effect of the interactions was
achieved according to the type of trait and the interacting factors, while the control treatment showed the lowest values of most of the traits.
Keywords: Date palm, Micro-elements, Gibberellic acid, Salicylic acid, yield.
Sweet and Salt Threshold Detection among Dental Implant Patients
in Relation to Cognition Status and Salivary Acetylcholinesterase
Authors: Hussein Ali Rihab Abdul , Sahib Diab Ban
Published: August 2023

Background: Wearing a dental implant may affect gustatory function,
an essential element of health in older adults that can affect cognition status. This
study aimed to assess the sweet and salt taste threshold detection among dental
implant patients in relation to cognition status and salivary Acetylcholinesterase
compared with partially edentulous and fully dentate patients matching in age
and gender. Materials and methods: The study comprised 90 dental implant patients between the ages of 50 and 60 compared with 90 partially edentulous and
90 fully dentate individuals who were age and gender-matched. The participants'
cognition status was tested using the Self-Administered Gero-cognitive Examination (SAGE) test, which classified them into poor and good. A two-alternative
forced-choice question was used to establish taste threshold sensitivity, with concentrations presented in ascending order. One chemical was investigated for each
taste quality (salt and sweet), and each component was delivered at five different
concentrations. The enzyme-linked immunosorbent test (ELISA) kit measured
salivary Acetylcholinesterase. Spss 22 Chicago Illionis USA was used to examine the data. Results: There was a significant association between sweet and salt
taste thresholds and the patient's groups, as the higher patient occurrence concerning the lowest taste threshold was found for the dentate patients.
In comparison, the higher patient occurrence for the highest taste threshold was
found for the partially edentulous patients. Data analysis showed a significant association between cognitive status and sweet and salt taste threshold for the implant patient group, as the percentage of patients with the lowest taste threshold
was higher for good cognitive status; the same result was found concerning partially edentulous and fully dentate patients; however, the association was not significant. The results revealed that the mean value of salivary Acetylcholinesterase
(AChE) was higher among the fully dentate group, followed by implant. Then,
the partially edentulous groups with statistically insignificant differences for both
poor and good cognitive status groups. On the other hand, when comparing the
poor and good cognitive status groups, results revealed that the mean value of
salivary Acetylcholinesterase was higher among the good than the poor groups,
with statistically significant differences among all sample groups. Conclusion:
Within the limitation of this investigation, it was confirmed that taste threshold
detection is connected with missing teeth and cognition status. The findings show
a complicated interplay of several factors that affect gustatory acuity, including
oral health and cognition status.
Keywords: Threshold, Dental Implant Patients, Salivary Acetylcholinesterase
Relationship between blood components, inflammatory factors and bacterial spp that cause tonsillitis and dental caries in Iraqi children
Authors: Shabeeb Dunia B. , N. Naji Eman
Published: August 2023

Aims and Objectives: Study the correlation between Anti streptolysin O Titer (ASOT) and Reactive Protein (CRP)with other related factors and the correlation between bacterial species and related tested parameters. Materials and Methods: 120 patients were part of the study and were divided into 6 groups; each group had 20 patients aged 6–12 years. Blood Sample Collection About 10 ml was withdrawn from each patient via vein puncture using 10 ml disposable syringes, 5 ml for immunological study and 5 ml for hematological study. Results: The results of ASOT titer showed a highly significant positive correlation with Monocytes and a highly negative correlation with eosinophil. CRP was found to have a highly significant positive correlation with eosinophils and lymphocytes and a highly negative correlation with neutrophil and monocyte percentage. With a positive correlation with ESR. Conclusion: Our study shows that ASOT is still a useful diagnostic tool for tonsillitis. CRP levels in the tonsillitis patients group were significantly higher than in other groups. In contrast, ESR levels in the tonsillectomy patients group were significantly higher than in other groups. Keywords: blood components, inflammatory factors, bacterial spp, tonsillitis, dental caries
Some Heavy metals measurements (Cadmium, Copper, and Zinc)
in the tissues of common carp Cyprinus carpioL . 1758 farmed in
floating cages in the Euphrates River.
Authors: Jassim Nassir Mokhtar , Kadhim Fahad Kamil
Published: August 2023

The current study examined the concentrations of three heavy metals
(cadmium, copper, and zinc) in the tissues of common carp fish. (gills-musclesintestines) collected from one of the private farms that raised fish in floating cages in the Euphrates River from 18/10/2021 to 18/3/2022. Every month, water
samples were analyzed, as were fish tissue samples. Using an atomic absorption
spectroscopy device, standard procedures were followed to assess the concentration of heavy metals in water and tissues. The results showed that the highest
concentration of zinc, cadmium, and copper was detected in the water during the
winter season, reaching (125.5-31.95-1.37) MKgm/L. The highest concentrations
of cadmium in tissues were found in the autumn season for gills and muscles
(1.58-0.81) mkgm/L dry weight, and the highest concentration in tissues (0.80)
mkgm/L dry weight in the winter. The highest concentrations of copper were
found in the gills and muscles, followed by the intestines. Where concentrations
are at their highest in the autumn season (11-9.89, 12.31) mkgm/gm dry weight.
As for zinc was found in high concentrations in the gills, intestines, and muscles,
with the highest concentrations recorded in the autumn season (81.6-85-93 – 112)
mkgm/gm dry weight. The results revealed that heavy metal accumulation occurred in the following pattern: Concentrations in water: cadmium <copper<zinc,
while in tissues, the arrangement was as follows: Cadmium – gills – muscles –
intestines – copper. Gills – muscles – intestines
Zinc – gills – intestines – muscles.
Keywords: Heavy metals, Cadmium, Copper, Zinc, common carp, Cyprinus
carpio L.
Response of Seed Yield and Its components of Several Genotypes of Vicia faba L. to Spraying of Zinc Nanoparticle
Fertilizer
Authors: A. mahdi Sinan , Abdul Kafoor Adil H.
Published: August 2023

A field experiment was conducted at a College of Agriculture research
station at - the University of Anbar during the winter season of 2021-2022 to study
the response of seed yield and its components of several genotypes of Vicia faba
L. to spraying of zinc nanoparticle fertilizer. The experiment was carried out by
Split Plots arrangement according to the Randomized Complete Block Design
(R.C.B.D.) at three replications. The main plots included four concentrations of
zinc nanoparticle fertilizer (0, 60, 12 and 180mg L-1
), whereas the sub-plots included four faba bean genotypes (Local, American, Dutch and Italian). The results
showed that the American genotype was significantly superior in the number of
pods per plant (21.40 pod plant-1
), fertility percentage per pod (88.80%), seed yield
(6.57 Mg ha-1
) and biological yield (11.01 Mg ha-1
). In contrast, the Dutch genotype achieved the highest mean of the number of seeds per pod (5.64 seed pod-1
)
and weight of 100 seeds (107.68 g). Also, the spraying of zinc nanoparticles at 180
mg L-1were significantly superior in the number of pods per plant (22.35 pod plant1
), weight of 100 seeds (111.40 g), fertility percentage per pod (90.30%), seed
yield (6.23 Mg ha-1
) and biological yield (10.78 Mg ha-1
), while the spraying of
zinc nanoparticle at a 120 mg L-1 gave the highest mean of the number of seeds per
pod (5.66 seed pod-1
). The interaction between two factors had a significant effect
on the most studied traits; the American genotype with the spraying of zinc nanoparticle at 180 mg L-1
gave the highest values of the number of pods per plant
(25.23 pod plant-1
), fertility percentage in a pod (91.14%) and seed yield (7.88 ton
ha-1
).
Keywords: Viciafaba L., nano-zinc, seed yield, yield components.
Impact of potassium in alleviating water stress on wheat plants irrigated with treated water Some vegetative growth characteristics
Authors: Abdul-Amir Ali Al-Fatlawy Sanaa Khadem , H.Alwan Abdoun , Al-Fatlawy Hassan J.
Published: August 2023

The study was conducted using plastic pots during the growing season
2020-2021 in private field crops at the Holy Karbala Governorate to study the effect of the quality of water, soil moisture and potassium levels on some growth
parameters of wheat plant var. A.L. baraka. A factorial experiment was carried
out using a completely randomized design (C.R.D.) with three replications, which
included two types of irrigation water treated heavy water and soft water, three
levels of field capacity, i.e., %, 50% and 100% and four levels of potassium, i.e.,
0, 1000, 2000 and 3000 mg. L-1 The experiment included 72 experimental units.
The results were statistically analyzed, and the means of treatments were compared using the least significant difference under the probability level 0.05. The
following characteristics were measurements: plant height, number of leaf areas,
dry weight of shoot and root systems. Results could be summarized as follows:
Water quality had a statistical effect on the traits under study, as the treatment
with treated heavy water gave the highest values of plant height, number of tillers, number of leaves, leaf area, root and shoots dry weights, which amounted to
70.21cm, 14.03leaf, 23.42cm2
, 6.24g, 1.76g respectively compared to soft water,
which amounted to 69.17 cm, 3.52tiller, 13.24leaf, 22cm2
, 58, 5.94 and 1.68g.
The addition of 100% of the field capacity value gave the highest averages of the
following height, number of leaves, leaf area, root and shoots dry weights, which
amounted to 80.80cm, 15.98leaves, 27.81cm2
, 7.69g and 2.15g sequentially. The
addition of 3000 mg.L-1
of potassium gave the highest averages for the traits
plant height, number of leaves, leaf area, shoot dry weight and root dry weight,
where their averages were 73.11cm, 14.66 leaves, 25.11cm2
, 6.63g and 1.87g respectively. Some bi- and tr-interactions between studied factors showed a different effect on the studied characteristics.
Keywords: Wheat plant, water quality, field capacity, potassium concentration.
The Impact of Heat Waves on Health Care Services in Low- or Middle-Income Countries: Protocol for a Systematic Review
Authors: Sapari Hadita , Selamat Mohamad Ikhsan , Isa Mohamad Rodi , Ismail Rohaida , Wan Mahiyuddin Wan Rozita
Published: August 2023

Background

Heat waves significantly impact ecosystems and human health, especially that of vulnerable populations, and are associated with increased morbidity and mortality. Besides being directly related to climate-sensitive health outcomes, heat waves have indirectly increased the burden on our health care systems. Although the existing literature examines the impact of heat waves and morbidity, past research has mostly been conducted in high-income countries (HICs), and studies on the impact of heat waves on morbidity in low- or middle-income countries (LMICs) are still scarce.

Objective

This paper presents the protocol for a systematic review that aims to provide evidence of the impact of heat waves on health care services in LMICs.

Methods

We will identify peer-reviewed studies from 3 online databases, including the Web of Science, PubMed, and SCOPUS, published from January 2002 to April 2023, using the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. Quality assessment will be conducted using the Navigation Guide checklist. Key search terms include heatwaves, extreme heat, hospitalization, outpatient visit, burden, health services, and morbidity.

Results

This systematic review will provide insight into the impact of heat waves on health care services in LMICs, especially on emergency department visits, ambulance call-outs, hospital admissions, outpatient department visits, in-hospital mortality, and health care operational costs.

Conclusions

The results of this review are anticipated to help policymakers and key stakeholders obtain a better understanding of the impact of heat waves on health care services and prioritize investments to mitigate the effects of heat waves in LMICs. This entails creating a comprehensive heat wave plan and ensuring that adequate infrastructure, capacity, and human resources are allocated in the health care sector. These measures will undoubtedly contribute to the development of resilience in health care systems and hence protect the health and well-being of individuals and communities.

Trial Registration

PROSPERO CRD42022365471; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=365471

International Registered Report Identifier (IRRID)

DERR1-10.2196/44702
Virtual Exercise in Medicine: A Proof of Concept in a Healthy Population
Authors: Le Roy Barbara , Martin-Krumm Charles , Poupon Charlotte , Richieri Raphaëlle , Malbos Eric , Barthélémy Fanny , Guedj Eric , Trousselard Marion
Published: August 2023

Background

Science is beginning to establish the benefits of the use of virtual reality (VR) in health care. This therapeutic approach may be an appropriate complementary treatment for some mental illnesses. It could prevent high levels of morbidity and improve the physical health of patients. For many years, the literature has shown the health benefits of physical exercise. Physical exercise in a VR environment may improve the management of mild to moderate mental health conditions. In this context, we developed a virtual environment combined with an ergocycle (the augmented physical training for isolated and confined environments [APTICE] system).

Objective

This study aims to investigate the impact of physical exercise in a VR environment.

Methods

A total of 14 healthy participants (11 men and 3 women; mean age 43.28, SD 10.60 years) undertook 15 minutes of immersive physical exercise using the system. Measures included mindfulness and immersion disposition, subjective perceptions of sensory information, user experience, and VR experience (ie, psychological state, flow, and presence).

Results

First, the APTICE system appears to be a useful tool because the user experience is positive (subscales in the AttrakDiff questionnaire: pragmatic quality=0.99; hedonic quality–stimulation=1.90; hedonic quality–identification=0.67; attractiveness=1.58). Second, the system can induce a positive psychological state (negative emotion, P=.06) and an experience of flow and presence (P values ranging from <.001 to .04). Third, individual immersive and mindful disposition plays a role in the VR experience (P values ranging from <.02 to .04). Finally, our findings suggest that there is a link between the subjective perception of sensory information and the VR experience (P values ranging from <.02 to .04).

Conclusions

These results indicate that the device is well accepted with positive psychological and exteroceptive outcomes. Overall, the APTICE system could be a proof of concept to explore the benefits of virtual physical exercise in clinical medicine.
Freely Available Training Videos for Suicide Prevention: Scoping Review
Authors: Wislocki Katherine , Jager-Hyman Shari , Brady Megan , Weiss Michal , Schaechter Temma , Khazanov Gabriela , Young Sophia , Becker-Haimes Emily
Published: August 2023

Background

Freely available and asynchronous implementation supports can reduce the resource burden of evidence-based practice training to facilitate uptake. Freely available web-based training videos have proliferated, yet there have been no efforts to quantify their breadth, depth, and content for suicide prevention.

Objective

This study presents results from a scoping review of freely available training videos for suicide prevention and describes a methodological framework for reviewing such videos.

Methods

A scoping review of freely available training videos (≥2 minutes) for suicide prevention practices was conducted using 4 large video-sharing platforms: YouTube, Vimeo, Bing Video, and Google Video. Identified suicide prevention training videos (N=506) were reviewed and coded.

Results

Most content was targeted toward gatekeepers or other lay providers (n=370) versus clinical providers (n=136). Videos most commonly provided content related to suicidal thoughts or behaviors (n=420). Many videos (n=274, 54.2%) included content designed for certain communities or organizations. Less than half (n=232, 45.8%) of training videos included formal clinical content pertaining to assessment or intervention for suicide prevention.

Conclusions

Results suggested an abundance of videos providing broad informational content (eg, “signs and symptoms of someone at risk for suicide”) and a limited portion of videos with instructional content aimed at clinical providers delivering formal evidence-based assessments or interventions for suicide prevention. Development of resources to address identified gaps may be needed. Future work may leverage machine learning techniques to expedite the review process.
Mobile Technology to Monitor and Support Health and Well-Being: Qualitative Study of Perspectives and Design Suggestions From Patients Undergoing Hematopoietic Cell Transplantation
Authors: Caparso Cinzia , Ozkan Gwynne , Kluge Maxwell , Salim Humza , Khaghany Aidan , Blok Amanda , Choi Sung Won
Published: August 2023

Background

In the United States, hematopoietic stem cell transplant (HCT) surpasses 22,000 procedures annually. Due to the demanding and time-intensive process of an HCT, patients and family care partners face unique challenges involving their health and well-being. Positive psychology interventions (PPIs) may offer potential solutions to help boost health and well-being.

Objective

This study aimed to explore and understand patients’ experiences and perceptions about the use of the Roadmap 2.0 app, specifically its PPI features, during the acute phase of HCT.

Methods

From an ongoing randomized controlled trial, HCT patients (n=17) were recruited to participate in semistructured qualitative interviews between October 2022 and January 2023 within a large academic medical center in the Midwestern states. Using a qualitative descriptive approach, interviews were conducted in person or via Zoom. The data were analyzed through constant comparative analysis. The Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines were followed.

Results

The majority of the participants reported Roadmap 2.0 as easy to use and enjoyed the ability to track their health data (eg, steps, mood, sleep; 9/17). Regarding the use of PPIs during the acute phase of treatment, 88% of the participants reported interest in participating in PPIs, specifically the Pleasant Activity Scheduling (11/17) followed by Gratitude Journaling (7/17) activities. Additionally, participants provided recommendations on adapting Roadmap 2.0. The major recommendations were (1) “Working Together: Need for Dyadic Involvement,” (2) “Connectivity with Other Patients,” and (3) “Gap in Nutritional Support.” Participants (10/17) expressed the importance of caregiver involvement in activities beyond treatment-related management for maintaining healthy patient-caregiver dyadic relationships. They also expressed their desire for connectivity with other patients undergoing HCT, primarily for comparing experiences and discussing topics such as symptom management (8/17). Lastly, participants identified a gap in nutritional support during the HCT process and expressed interest in an intervention that could promote healthy eating through education and notification reminders (9/17).

Conclusions

Participants openly expressed their eagerness to participate in research studies that foster connection and positive relationships with their caregivers as well as with other HCT patients. They emphasized the significance of having access to nutritional support or guidance and highlighted the potential benefits of using mobile technology to enhance these collective efforts.

Trial Registration

ClinicalTrials.gov NCT04094844; https://clinicaltrials.gov/study/NCT04094844

International Registered Report Identifier (IRRID)

RR2-10.2196/19288
Advanced Messaging Intervention for Medication Adherence and Clinical Outcomes Among Patients With Cancer: Randomized Controlled Trial (Preprint)
Authors: Ni Chen-Xu , Lu Wen-Jie , Ni Min , Huang Fang , Li Dong-Jie , Shen Fu-Ming
Published: August 2023

BACKGROUND

Medication adherence is crucial for improving clinical outcomes in the treatment of patients with cancer. The lack of adherence and adverse drug reactions can reduce the effectiveness of cancer therapy including the quality of life. The commonly used intervention methods for medication adherence continue to evolve, and the age of fifth-generation (5G) messaging has arrived.

OBJECTIVE

In this study, we conducted a prospective, pilot randomized controlled trial to evaluate the effect of 5G messaging on medication adherence and clinical outcomes among patients with cancer in China.

METHODS

The research population was patients with nonsmall cell lung cancer undergoing pemetrexed chemotherapy who require regular folic acid (FA) and vitamin B12 supplements. The intervention and control groups were assigned to 5G messaging and second-generation (2G) messaging, respectively. The patients’ medication adherence and quality of life were assessed at baseline and 1-month and 3-month time points. Moreover, the chemotherapy-related hematologic or nonhematologic toxicities, as well as the serum levels of FA and vitamin B12, were measured.

RESULTS

Of the 567 patients assessed for eligibility between January and May 2021, a total of 154 (27.2%) patients were included. Overall, 80 were randomized to the control group and 74 to the intervention group. The odds of adherence in the 5G messaging intervention group were significantly higher than the control group at the 1-month (62/69, 90% vs 56/74, 76%; adjusted odds ratio 2.67, 95% CI 1.02-7.71) and 3-month (50/60, 83% vs 48/64, 75%; adjusted odds ratio 2.36, 95% CI 1.00-5.23) time points. Correspondingly, the FA and vitamin B12 serum levels of patients in the 5G messaging group were higher than those of the control group. Regarding hematologic toxicities, only the incidence of leukopenia in the intervention group was lower than that in the control group (25/80, 31% in the control group vs 12/74, 16% in the intervention group; P=.04). There were no differences in nonhematologic toxicities and quality of life between the 2 groups.

CONCLUSIONS

In summary, we conclude that compared with conventional 2G text-based messaging, a 5G messaging intervention can better improve medication adherence and clinical outcome among patients with cancer.

CLINICALTRIAL

Chinese Clinical Trial Registry ChiCTR2200058188; https://www.chictr.org.cn/showproj.html?proj=164489
Deferring Postoperative Follow‑Up Visits up to 4 Weeks After Uneventful Cataract Surgery in a Tertiary Level Eye Hospital: Protocol for a Prospective, Quantitative, Experimental Control Study (Preprint)
Authors: Parajuli Sanket , Dhakhwa Parami , Adhikary Rabindra
Published: August 2023

BACKGROUND

Routine examination after cataract surgery, including a refraction test 4 to 6 weeks after surgery, is mandatory in most hospitals. In recent years, there has been growing interest in exploring alternative approaches to postoperative follow-up in cataract surgery patients due to the increasing number of cataract surgeries being performed, the limited availability of health care resources, and the need to optimize the use of health care services.

OBJECTIVE

We aim to compare postoperative visual outcomes after a day 0 examination in patients with 2 follow‑ups, one on day 7 and other on day 30, and patients with a single ophthalmic follow‑up between days 25 to 30.

METHODS

A prospective, quantitative, experimental control study will be carried out in Reiyukai Eiko Masunaga Eye Hospital, located in Banepa, Kavrepalanchok, Nepal. All patients undergoing cataract surgery meeting the inclusion and exclusion criteria irrespective of the type of surgery (small-incision cataract surgery or phacoemulsification) will be included in the study. The patients will be randomly assigned to 1 of 2 groups. Patients in group 1 will be examined on day 1, day 7, and day 30, whereas patients in group 2 will be examined on day 1 and once between days 25 to 30. The minimum clinically important difference (MCID) in our study will be set according to the improvement in the Snellen visual acuity chart.

RESULTS

The study is expected to be completed within 6 to 8 months from the start of the project. Data analysis and report writing will be carried out in a 2-month period. Best-corrected visual acuity will be compared between the 2 groups to determine if the MCID is achieved. The cost-effectiveness of the new approach will also be analyzed.

CONCLUSIONS

We aim to conclude that we can safely defer the 1-week postoperative follow-up visit in patients undergoing uncomplicated cataract surgery and that, moreover, we can reduce the patient load at the hospital and decrease patient expenses by decreasing the frequency of hospital visits.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/48616
Mobile Technology to Monitor and Support Health and Well-Being: Qualitative Study of Perspectives and Design Suggestions From Patients Undergoing Hematopoietic Cell Transplantation (Preprint)
Authors: Caparso Cinzia , Ozkan Gwynne , Kluge Maxwell , Salim Humza , Khaghany Aidan , Blok Amanda , Choi Sung Won
Published: August 2023

BACKGROUND

In the United States, hematopoietic stem cell transplant (HCT) surpasses 22,000 procedures annually. Due to the demanding and time-intensive process of an HCT, patients and family care partners face unique challenges involving their health and well-being. Positive psychology interventions (PPIs) may offer potential solutions to help boost health and well-being.

OBJECTIVE

This study aimed to explore and understand patients’ experiences and perceptions about the use of the Roadmap 2.0 app, specifically its PPI features, during the acute phase of HCT.

METHODS

From an ongoing randomized controlled trial, HCT patients (n=17) were recruited to participate in semistructured qualitative interviews between October 2022 and January 2023 within a large academic medical center in the Midwestern states. Using a qualitative descriptive approach, interviews were conducted in person or via Zoom. The data were analyzed through constant comparative analysis. The Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines were followed.

RESULTS

The majority of the participants reported Roadmap 2.0 as easy to use and enjoyed the ability to track their health data (eg, steps, mood, sleep; 9/17). Regarding the use of PPIs during the acute phase of treatment, 88% of the participants reported interest in participating in PPIs, specifically the Pleasant Activity Scheduling (11/17) followed by Gratitude Journaling (7/17) activities. Additionally, participants provided recommendations on adapting Roadmap 2.0. The major recommendations were (1) “Working Together: Need for Dyadic Involvement,” (2) “Connectivity with Other Patients,” and (3) “Gap in Nutritional Support.” Participants (10/17) expressed the importance of caregiver involvement in activities beyond treatment-related management for maintaining healthy patient-caregiver dyadic relationships. They also expressed their desire for connectivity with other patients undergoing HCT, primarily for comparing experiences and discussing topics such as symptom management (8/17). Lastly, participants identified a gap in nutritional support during the HCT process and expressed interest in an intervention that could promote healthy eating through education and notification reminders (9/17).

CONCLUSIONS

Participants openly expressed their eagerness to participate in research studies that foster connection and positive relationships with their caregivers as well as with other HCT patients. They emphasized the significance of having access to nutritional support or guidance and highlighted the potential benefits of using mobile technology to enhance these collective efforts.

CLINICALTRIAL

ClinicalTrials.gov NCT04094844; https://clinicaltrials.gov/study/NCT04094844

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/19288
Towards objective and explainable assessment of surgical skill with deep learning (Preprint)
Authors: Khalid Shuja
Published: August 2023

BACKGROUND

Currently, evaluating surgical technical performance is inefficient and subjective and the established rubrics for assessing surgical ability are open to interpretation. To power programs for surgical training and Maintenance of Certification (MOC), a reliable and validated solution is required.

OBJECTIVE

We draw upon recent advances in machine learning and propose a framework for objective and scalable assessment of technical proficiency.

METHODS

Different machine learning models were trained to predict surgical performance on the public EndoVis19 and JIGSAWS datasets. The most important features were extracted by probing each machine learning model, and these features form the basis of the proposed algorithm. We internally tested the performance of this model on proprietary datasets from Surgical Safety Technologies (SST) and the University of Texas Southwestern (UTSW). The performance of these models was assessed according to various statistical techniques such as precision, recall, f1-scores and the area under the receiver operating characteristic curve (AUC).

RESULTS

OR Vision is a statistically-driven multi-stage machine learning tool that quantifies surgical skill objectively and explainably. Instrument motion, control, and coordination are quantified in terms of 150 objective metrics, extracted from tool motion tracked by the deep learning model. The N most highly correlated of these metrics (p<0.05) model surgical performance with quantifiable objective metrics (fine-motor precision, fluidity, tremor, disorder, etc.). These metrics are combined into clinically-relevant composite scores that represent the technical performance of surgeons. The OR Vision score discriminates between expert and novice surgeons with high precision (0.82-0.84) and provides constructive feedback in the form of a concise report for every participating member of the cohort. Each report provides a breakdown of user performance on statistically relevant categories.

CONCLUSIONS

A machine learning-based approach for identifying surgical skill is effective and meaningful and provides the groundwork for objective, precise, repeatable, cost-effective, clinically-meaningful assessments.
Nonlinear Finite Element Simulation and Analysis of Steel Frame Structures Considering Nonlinear Behavior
Authors: Mou Yanling
Published: August 2023

This paper focuses on investigating the nonlinear behavior of steel frame structures in practical engineering applications. Utilizing finite element analysis, the study simulates the response of structures under extreme loads such as strong earthquakes. By incorporating nonlinear material properties and contact effects, the numerical simulation and analysis explore phenomena such as plastic deformation, yield, and instability in frame structures. The research outcomes contribute to a deeper understanding of the energy dissipation and safety performance of these structures.
The application of logotherapy to improve the meaning of life in emerging adults with self-injury
Authors: Maurits Reisha Hermana , Hatta Muhammad Ilmi , Suhana Suhana
Published: August 2023

Self-injury occurs commonly in young people, especially during the development phase of emerging adults. It is seen as a manifestation of existential problems, such as obstacles in fulfilling or pursuing meaning in life which is the most basic human motivation. This study aims to determine the effect of logotherapy as an intervention to increase purpose in life in emerging adults who engage in self-injury. The research utilized a single case experiment A-B design involving two subjects, measuring their level of meaning in life with the Meaning in Life Questionnaire (MLQ). The analysis technique of visual analysis, baseline-corrected tau, and Reliable Change Index (RCI) yielded outcomes indicating logotherapy as an effective intervention option for increasing meaning in life in emerging adults with self-injury.
USO DE CONCENTRADO PLAQUETARIO AUTOLOGO NO REJUVENESCIMENTO FACIAL: uma revisão narrativa da literatura
Authors: Faria Laís Almeida , Araújo Vanessa Brandão de Oliveira , Gomes Lorena Caixeta
Published: August 2023

Platelet-rich plasma (PRP) is an autogenous compound acquired through the collection and processing of the patient's own blood. The procedure allows the acquisition of high concentration of platelets from small volumes of processed fluids. Platelets, because they have growth factors and cellular proteins, stimulate tissue repair, formation of new blood vessels, increasing vascularization, activating the production of collagen and elastin, proteins that are indispensable for a structured and healthy skin. Thus, this narrative literature review proposes to expose the use of PRP in collagen biostimulation and facial rejuvenation. In this research, the main functions of the growth factors present in PRP were discussed, the expected indications for each component obtained after plasma processing and the main forms of application to treat skin aging.
Mobilização no campo cultural em tempos de pandemia
Authors: Barbalho Alexandre
Published: August 2023

Este artigo busca analisar se e como ocorreu o processo de mobilização política na página “Lei Emergência Cultural Aldir Blanc” do Facebook, mantida pela Articulacão Nacional de Emergência Cultural (ANEC), o mais importante coletivo organizado em torno da pauta das políticas emergenciais para o setor. A hipótese que guiou a pesquisa foi a de que, com a ampla mobilização e o engajamento reivindicados pelo movimento, a página, além de publicizar as ações do coletivo, funcionou como esfera pública virtual, onde se discutiu questões e pautas da causa. A pesquisou revelou uma quase ausência de interação dos usuários, ao contrário do que supunha, e concluiu que não houve interesse em promover o engajamento por meio de postagens que demandassem o posicionamento dos seguidores da ANEC.
Ensaio sobre as predicações da influência
Authors: Freire Simões Pires Arthur
Published: August 2023

Resenha de Influenciadores sociais: o feitiço, a fama e a fé, de Jacques Wainberg.
PERTUMBUHAN DAN HASIL TANAMAN SELEDRI (Apium graveolens L.) PADA PEMBERIAN PUPUK ORGANIK CAIR
Authors: Ardi Ardi , Nuraeni Nuraeni
Published: August 2023

Seledri (Apium graveolens L.) merupakan tanaman sayuran sudah lama dikenal di Indonesia.Tanaman seledri memiliki banyak manfaat. Daun dan tangkai daun seledri dapat digunakan sebagai campuran sup dan bahan makanan berkuah lainnya. Seledri juga dapat digunakan sebagai tanaman biofarma, yaitu untuk mengobati berbagai penyakit seperti demam, flu, gangguan pencernaan, limpa dan hati. Penelitian bertujuan untuk mendapatkan konsentrasi Pupuk Organik Cair (POC) yang terbaik untuk meningkatkan pertumbuhan dan hasil tanaman seledri. Penelitian diharapkan dapat menjadi bahan informasi kepada petani dalam upaya meningkatkan kualitas tanaman seledri dengan menggunakan pupuk organik cair. Penelitian dilaksanakan di Desa Omu Kecamatan Gumbasa Kabupaten Sigi Sulawesi Tengah pada Bulan Februari sampai dengan Agustus 2020. Penelitian ini disusun menggunakan Rancangan Acak Kelompok (RAK), satu faktor yaitu konsentrasi Pupuk Organik Cair. Terdiri dari empat taraf, yaitu perlakuan tanpa Pupuk Organik Cair, 1%, 3% dan 5%. Dengan demikian terdapat 4 perlakuan, setiap perlakuan di ulang 4 kali sehingga diperoleh 16 unit percobaan, setiap unit percobaan terdiri dari 4 tanaman sehingga keseluruhan terdapat 64 unit percobaan. Hasil penelitian menunjukan bahwa pemberian pupuk organik cair memberikan pengaruh yang nyata, konsentrasi 1% merupakan konsentrasi yang terbaik untuk meningkatkan pertumbuhan dan hasil tanaman seledri. Hal ini memberikan pengaruh sangat nyata pada pengamatan tinggi tanaman, jumlah daun, jumlah anakan, volume akar dan bobot kering tanaman.
PENGARUH PEMBERIAN PUPUK ORGANIK CAIR (POC NASA)TERHADAP PERTUMBUHAN DAN HASIL TANAMAN SELADA (Lactuca sativa L.)
Authors: Supyandi Supyandi , Rahmi Rahmi
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian pupuk organik cair nasa terhadap pertumbuhan dan hasil tanaman selada (lactuca sativa L.) dan meningkatkan kualitas dan kuantitas produksi tanaman serta kelestarian lingkungan/tanah. Penelitian ini di laksanakan kurang lebih 2 bulan, dari bulan februari 2021 sampai maret 2021, yang bertempat di green house, fakultas pertanian, universitas tadulako, palu sulawesi tengah. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK)satu Faktor , yaitu perlakuan konsentrasi pupuk organik cair NASA yang terdiri atas 5 taraf perlakuan yaitu, kontrol tanpa POC NASA (K0), pemberian POC NASA 2ml/L air (K1), pemberian POC NASA 4ml/L air (K2), pemberian POC NASA 6ml/L air (K3), pemberian POC NASA 8ml/L air (K4). Setiap perlakuan diulang tiga kali sehingga diperoleh 15 unit percobaan. Setiap unit percobaan menggunakan dua polybag, dengan demikian total yang digunakan sebanyak 30 polybag. Berdasarkan hasil penelitian yang dilakukan bahwa pemberian pupuk organik cair POC NASA berpengaruh lebih baik dibandingkan dengan tanpa perlakuan pemberian pupuk cair POC NASA pada semua parameter pengamatan pertumbuhan tanaman selada (tinggi tanaman, jumlah daun, panjang daun, lebar daun, berangkasan basah total, berat bagian atas akar dan berat akar) dan pada hampir semua waktu pengamatan, kecuali hanya pada umur 7 HST pada parameter pertumbuhan panjang daun dan lebar daun tanaman selada.
Research of trusted real-time electrical data transmission mechanism based on parallel proof of work algorithm
Authors: Yiming Chen , Doliang Gao , Yuxuan Yang , Jintang Luo , Li Yi
Published: August 2023

Secure and reliable electricity supply is a prerequisite for the
development of smart cities, and the trustworthy and efficient
transmission of electrical data is the foundation for the safe and
stable operation of the power grid. This paper introduces a real-time
data transmission blockchain technique based on parallel proof of work
algorithm. The new block generation progress of proposed blockchain is
divided into five subroutines: hash pointer computation, real-time data
pudding, signature value iteration, interruption, block header assembly.
The real-time data pudding and signature value iteration are parallel
processed, which brings the effect of decreasing energy loss of
blockchain system, and upgrades the speed of new block generation and
the bandwidth of data storing on blockchain. Computer simulation shows
the proposed strategy can be effectively applied in real-time electrical
data transmission application, raising the data transmission reliability
with no harm to real-time data transfer function. This strategy provides
a solution to guarantee data transmission safety in the digital
conversion of power grid.
((Commentary on pmic.202300239 - title of the commentary t.b.a.)) Beyond the model organism – Mechanistic analysis of protein post-translational modifications is ready for all challengers
Authors: Orsburn Benjamin
Published: August 2023

A historic challenge for shotgun proteomics has been the requirement for
high quality, simple and nonredundant curated protein sequences in small
.fasta text files. Due to the intrinsic informatic challenges and time
required to assemble these files, proteomics has struggled to expand
beyond the confines of a few model organisms. When considering
post-translational modifications that may or may not be present on a
specific peptide sequence, these factors inevitably compound. A study on
how mangos continue to ripen on the shelf may not be the first thing
you’d think of as proof of a scientific discipline shedding historic
limitations. However, Bautiste-Valle et al., may be just that. These
authors present a quantitative comparison of both peptide and
glycopeptide alterations through the complexity of the fruit ripening
process and in this we see the present state of a field that no longer
needs to wait on genomics to obtain deep mechanistic insights.