bluuebunny/crossref_metadata_2025 huggingface dataset:
Percutaneous Vertebroplasty Versus Balloon Kyphoplasty in the Treatment of Osteoporotic Vertebral Compression Fractures: Evaluating the Overlapping Meta-analyses
Authors: Jia Zhiwei
Published: January 2025

BACKGROUND: Numerous meta-analyses and systematic reviews have explored the differences between percutaneous vertebroplasty (PVP) and percutaneous balloon kyphoplasty (PKP) for treating osteoporotic vertebral compression fractures (OVCFs), however, their final conclusions have been inconsistent. The inconsistent conclusions drawn from these meta-analyses create uncertainty among clinicians about the best treatment approach for OVCFs.

OBJECTIVE: The aim of this study was to conduct a cross-sectional analysis of overlapping meta-analyses comparing PVP and PKP treatments for OVCF in order to help clinicians have access to the best available evidence and provide treatment recommendations based on the best available evidence.

STUDY DESIGN: A cross-sectional analysis of overlapping meta-analyses.

METHODS: We conducted a comprehensive search of meta-analyses published up to February 2023 in PubMed, Embase, Cochrane Library and Web of Science databases to identify relevant studies. The methodological quality of these studies was assessed using the Assessment of Multiple Systematic Reviews tool (original AMSTAR) and the Oxford Centre for Evidence-based Medicine Levels of Evidence. Two researchers independently extracted the data and assessed the quality of these meta-analyses. To determine which meta-analyses represented the best evidence, we employed the Jadad decision algorithm.

RESULTS: Seventeen meta-analyses were included in the study, with AMSTAR scores ranging from 4 to 9, with an average of 7. After rigorous scrutiny, the Zhu et al study was determined to provide the best evidence. According to their findings, both PVP and PKP effectively alleviate pain and improve function in the treatment of OVCFs, without any statistically significant differences between them. In addition, PKP can reduce the risk of polymethylmethacrylate leakage compared to PVP.

LIMITATIONS: This study analyzed published overlapping meta-analyses, inherently confining our investigation to the meta-analysis level. Furthermore, based on the AMSTAR scores, several included studies exhibited lower methodological quality.

CONCLUSIONS: Currently, the best evidence indicates that PVP and PKP are equally effective at alleviating pain and enhancing function in the treatment of OVCFs, but PKP had a lower incidence of polymethylmethacrylate leakage. However, there is still a need for high-quality randomized controlled trials to provide higher levels of evidence regarding other aspects of the differences between the 2 procedures.

KEY WORDS: Osteoporotic vertebral compression fractures, percutaneous vertebroplasty, balloon kyphoplasty, systematic review, meta-analyses
The Effect of Sedation on Diagnostic Lumbar Medial Branch Blocks for Facetogenic Low Back Pain: An Observational Study
Authors: Patel Nimesh
Published: January 2025

BACKGROUND: Lumbar medial branch blocks (MBB) are some of the most commonly performed pain procedures in the United States. Diagnostic MBBs are performed to confirm if the generator of low back pain is the facet joint. However, with diagnostic injections, false positive blocks may occur.

OBJECTIVES: Our prospective observational study aims to investigate the effects of midazolam sedation on patients’ perceived intensity of pain relief following lumbar MBB.

STUDY DESIGN: This is a single-center multi-site prospective observational study registered on clinicaltrials.gov (NCT04453449).

SETTING: The study was approved by the Henry Ford Health System Institutional Review Board (IRB) in June 2020 (IRB# 14010) and registered on clinicaltrials.gov in July 2020 (NCT04453449). This manuscript adheres to the applicable EQUATOR STROBE guidelines for an observational cohort study.

METHODS: Patients that underwent MBB without sedation were compared to sedated patients. Patients were asked to complete the Numeric Rating Scale (NRS) at baseline, one day after their diagnostic blocks, as well as 4 weeks and 8 weeks after their lumbar radiofrequency ablation (RFA). The primary outcome is the difference between baseline NRS pain scores and the lowest reported score in the 8 hours following MBB. For patients who proceed to RFA, the frequency of false positive blocks was evaluated. A patient was considered to have a false positive block when they failed to achieve 50% pain relief from RFA after 2 successful sequential MBBs.

RESULTS: There was no significant difference in the NRS pain score change between the sedated and non-sedated groups for diagnostic block one (P = 0.167) and diagnostic block 2 (P = 0.6145). There was no significant difference of false positive rates between non-sedation and sedation patients at 4-weeks post-RFA (P = 0.7178) and at 8-weeks post-RFA (P = 1.000).

LIMITATIONS: Some of the limitations of this study include its nonrandomized design, patient self-reported pain scores, as well as the small variability in the injection technique of proceduralists and in the anatomical location of the injection site.

CONCLUSIONS: This study showed that midazolam did not change patients’ perceived intensity of pain following MBB, as well as false positive rates after RFA. Larger studies are required to draw definitive conclusions.

KEY WORDS: Medial branch blocks, diagnostic, radiofrequency ablation, back pain, chronic pain, facet joint, medial branch ablation
Effectiveness of Radiofrequency Ablation of the Genicular Nerves of the Knee for the Management of Intractable Pain from Knee Osteoarthritis
Authors: Chang Min Cheol
Published: January 2025

BACKGROUND: The knee joint is one of the most common diseases in elderly individuals. This is a progressive and debilitating condition. The purpose of knee osteoarthritis treatment is to manage pain, increase mobility, and improve the quality of life.

OBJECTIVES: This study evaluated the therapeutic effect of radiofrequency thermocoagulation (RFTC) on the genicular nerves in patients with intractable pain due to knee osteoarthritis, as well as its effects on pain severity and magnetic resonance imaging (MRI) findings.

STUDY DESIGN: A prospective outcome study.

SETTING: The outpatient clinic of a single academic medical center.

METHODS: We conducted a prospective study. Fifty consecutive patients with intractable knee pain due to osteoarthritis were enrolled and underwent ultrasound (US)-guided RFTC of the genicular nerves (medial superior genicular nerve, medial inferior genicular nerve, and lateral superior genicular nerve). Pain severity was measured using the Numeric Rating Scale (NRS), and knee osteoarthritis-associated symptoms were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at pretreatment and one, 3, and 6 months after RFTC treatment. We also analyzed the relationship between therapeutic outcomes and pain severity based on pre-treatment and knee MRI findings.

RESULTS: No dropouts were observed. The most significant reduction in knee symptoms associated with knee osteoarthritis was observed after one month of treatment; however, at 3 and 6 months, there was a rebound effect, leading to a decrease in therapeutic efficacy. Nonetheless, there was still a noticeable decrease in symptoms due to knee osteoarthritis compared to those prior to RFTC treatment. The effect of RFTC treatment was better when pre-treatment pain was relatively less severe, knee effusion was not severe, there were no meniscal tears in the middle or posterior zones, no bone marrow edema in the middle and posterior zones of the femur and tibia, and no severe cartilage defects in the posterior femur and middle and posterior tibia.

LIMITATIONS: We conducted our study without a control or a placebo group.

CONCLUSION: RFTC of the genicular nerve is a good therapeutic option for controlling intractable pain following knee osteoarthritis. In addition, we found that a lower level of pain prior to treatment, along with the absence or lesser degree of knee joint effusion, as well as an absence or less severe middle or posterior knee pathologies associated with knee osteoarthritis, can predict a more favorable therapeutic outcome.

KEY WORDS: knee, osteoarthritis, radiofrequency ablation, genicular nerve, pain, magnetic resonance imaging
Hair Loss as a Side Effect of Quetiapine: A Clinical Case Report
Authors: Rhaouti A. K. , Stati S. , Khallouk A. , Boukidi H. , Boukdir A. , Belakbir O. , Laboudi F. , Ouanass A.
Published: January 2025

Introduction: Quetiapine is an atypical antipsychotic that acts as an antagonist on serotonin, dopamine, histamine, and adrenergic receptors. It is approved for the treatment of schizophrenia and mood disorders and is commonly used off-label for depression, anxiety, and insomnia. Common side effects include drowsiness, dizziness, and headaches. Although hair loss is a rare side effect of psychotropic medications, it has been reported with certain drugs but remains poorly documented. Case: We report the case of a 37-year-old man treated for major depressive disorder who experienced hair loss after two months of quetiapine treatment. Following the discontinuation of quetiapine, hair loss stopped, and hair regrowth was observed. Discussion: This is the first documented case in Morocco associating quetiapine with hair loss. Telogen effluvium, a condition of hair loss often triggered by stress or medications, can occur with psychotropic drugs like certain mood stabilizers and antipsychotics. Similar cases have been reported in New Zealand, Turkey, and Germany. Conclusion: Quetiapine is widely prescribed in Morocco, but this case highlights the need for awareness regarding rare side effects like hair loss. This study suggests a reevaluation of quetiapine’s tolerability and encourages further research to better understand these potential side effects and improve prescribing practices.
When Psychiatric Symptoms Reveal Huntington's disease: An Illustrative Case Study
Authors: Rhaouti A. K. , Stati S. , Khallouk A. , Boukidi H. , Boukdir A. , Belakbir O. , Sabir M.
Published: January 2025

Introduction: Huntington’s disease (HD) is a rare genetic disorder with autosomal dominant inheritance, caused by CAG repeat expansions in the IT15 gene. It affects about 1 in 10,000 people and leads to neurodegeneration, primarily impacting the striatum and later causing cortical atrophy. Clinically, HD presents with motor, cognitive, and psychiatric symptoms, with psychiatric manifestations often occurring early and causing diagnostic confusion. Clinical Observation: A case of Mrs. S.M., a 40-year-old woman hospitalized for aggressive behavior, is discussed. Initially diagnosed with brief psychotic disorder, she later developed dysarthria and choreic movements. Genetic testing confirmed HD, underscoring the complex psychiatric presentation that can precede motor symptoms. Discussion: Psychiatric symptoms are common in HD and may appear before motor issues, often leading to misdiagnosis. These symptoms, including aggression, depression, and psychosis, correlate with underlying brain degeneration. Treatment generally involves atypical antipsychotics like quetiapine for better tolerance. Conclusion: HD’s early psychiatric symptoms can obscure diagnosis. Effective management focuses on multidisciplinary care to sustain patient autonomy and quality of life.
Strategi Pengembangan UMKM Caldera Resto And Coffee Dengan Menggunakan Blue Ocean Strategy Dan Sistem Dinamik
Authors: Lumbanraja Sonia
Published: January 2025

This study aims to design the right development strategy for MSMEs Caldera Resto and Coffee. The methods used are SWOT analysis, Blue Ocean Strategy, and System Dynamics. Data collection was conducted by distributing questionnaires to 100 respondents who visited Caldera Resto. The sampling technique used in the study is purposive sampling. The results showed that the development strategy designed greatly affect the increase in revenue at Caldera Resto and Coffee.
Evaluasi Waktu Kerja Operator pada Proses Cutting di Perusahaan Manufaktur dengan Metode Maynard Operation Sequence Technique (MOST)
Authors: Bora M Ansyar , Gunadi  , Permatasari Ririt Dwiputri , Herman  , Nur Shilah
Published: January 2025

Produktivitas kerja menjadi perhatian penting dalam industri karena berpengaruh langsung terhadap efisiensi dan output perusahaan. Penelitian ini bertujuan untuk menganalisis metode kerja operator cutting proses di Perusahaan manufaktur dengan menggunakan metode Maynard Operation Sequence Technique (MOST). Masalah utama yang ditemukan adalah banyaknya waktu kerja yang terbuang akibat aktivitas transportasi operator, yang berdampak pada rendahnya output produksi. Metode kerja awal menunjukkan waktu baku sebesar 30,015 menit/box dengan output standar 16 box/hari atau 672 lembar material/hari. Dengan menghilangkan aktivitas transportasi dalam metode kerja usulan, waktu baku menurun menjadi 20,4775 menit/box, menghasilkan output standar 24 box/hari atau 1008 lembar material/hari, sehingga mencapai target perusahaan. Hasil penelitian ini menunjukkan bahwa perbaikan metode kerja dapat meningkatkan efisiensi waktu dan jumlah produksi secara signifikan. Temuan ini penting untuk mendukung peningkatan produktivitas tenaga kerja dan optimalisasi proses produksi di industri manufaktur.
Características clínicas y epidemiológicas de pacientes con mesotelioma en un centro médico de alta complejidad
Authors: Lagos-Hernández Karen , Apraez-Mazabel Nayla Andrea , Ordosgoitia-Dickson Luis , Cabrales-Dajil Heriberto José , Vides-Osorio Ana Milena , Díaz-Suárez Esteban David , Cabarcas-González Rubén Darío , Cabrera-Fuentes Rafael de Jesús , Jayk-Bernal Angelica , Vergara-Serpa Oscar
Published: January 2025

Introducción: Mesotelioma maligno (MM) es un cáncer poco común causado principalmente por la exposición al asbesto, se encuentra con mayor frecuencia en la pleura y presenta una alta tasa de mortalidad. Aunque muchos países han prohibido el asbesto, su uso fue permitido en Colombia hasta 2020, manteniéndose como un tema relevante de salud pública. Objetivo: Describir las características clínicas y epidemiológicas de pacientes con MM tratados en un centro oncológico de referencia en Montería, Colombia. Métodos: Se realizó un estudio descriptivo, transversal, en 11 pacientes con MM entre 2015 y 2022. Se incluyeron pacientes con diagnóstico histológico confirmado y un seguimiento mínimo de 2 años. Las variables clínicas, demográficas y de supervivencia se analizaron mediante análisis univariado, Kaplan-Meier o pruebas Log-rank. Resultados: 73% fueron mesoteliomas pleurales, el 27% peritoneales, predominó el tipo epitelioide. 9% de los pacientes recibió quimioterapia antes de la cirugía, el 73% fue tratado inicialmente con cirugía. La mediana de supervivencia global fue 19 meses. Todos los pacientes con mesotelioma peritoneal fallecieron. 66% de los pacientes reportó exposición al asbesto. Conclusión: El estudio confirma la alta mortalidad del MM, especialmente en su forma peritoneal, y subraya la necesidad de diagnósticos más tempranos y tratamientos efectivos. A pesar de la reciente prohibición del asbesto, la exposición sigue siendo un riesgo crítico.
Taponamiento cardíaco y pericarditis purulenta como debut de lupus eritematoso sistémico
Authors: García-Chamorro Luis Guillermo , Mestre-Sequeda Epitafio Rafael
Published: January 2025

La pericarditis purulenta (PP) es una entidad grave que puede evolucionar a taponamiento cardíaco y rara vez suele cursar como debut del lupus eritematoso sistémico (LES). Presentamos el caso de una mujer de 25 años, con disnea, hipotensión arterial, taquicardia y compromiso hemodinámico secundario a taponamiento cardíaco diagnosticado por ecocardiografía. Durante la hospitalización se realizó el diagnóstico de LES, recibió tratamiento de emergencia con pericardiocentesis y se le administraron glucocorticoides e inmunosupresores. Finalmente, el derrame pericárdico se resolvió gradualmente y los síntomas de la paciente mejoraron.
Dolor mandibular como manifestación atípica de disección aórtica
Authors: Requejo Harrinson
Published: January 2025

Si una disección aórtica con presentación clínica atípica se diagnostica tardíamente tiene alto riesgo de complicaciones y mortalidad. Se reporta un caso de dolor mandibular como síntoma inicial de disección aórtica. Presentación del caso: se reporta un varón de 38 años el cual presenta dolor mandibular como síntoma inicial de disección aórtica aguda, el cual se extendió hasta aorta abdominal y arterias renales. Conclusiones: El dolor mandibular es una manifestación poco frecuente o rara como síntoma inicial de disección aórtica aguda, además esta patología es una emergencia médica de primer orden que requiere tratamiento quirúrgico de inmediato.
IDENTIFIKASI VARIETAS BIBIT DURIAN MENGGUNAKAN MOBILENETV2 BERDASARKAN GAMBAR DAUN
Authors: Didi Kurniawan  , Dhani Ariatmanto
Published: January 2025

Durian merupakan tanaman buah yang sangat berharga dan menyediakan sumber pendapatan yang berkelanjutan bagi petani. Durian terdapat berbagai varietas yang memiliki ciri khas yang unik, termasuk perbedaan dalam bentuk, warna, rasa dan aroma dari daging buahnya. Identifikasi bibit durian yang akurat penting bagi petani untuk memaksimalkan potensi pertanian dalam memenuhi permintaan pasar yang sesuai. Namun, mengidentifikasi jenis bibit durian secara manual seringkali merupakan tugas yang rumit dan subjektif, terutama bagi petani yang kurang berpengalaman. Penelitian ini menggunakan arsitektur MobileNetV2 untuk mengidentifikasi jenis bibit durian berdasarkan gambar daun. Model dilatih dengan berbagai kombinasi learning rate dan batch size menggunakan Adam optimizer. Tahap prapemrosesan melibatkan penghapusan latar belakang dan penggunaan bounding box untuk memfokuskan pada daun durian. Hasil menunjukkan bahwa MobileNetV2 dapat mengklasifikasikan varietas durian dengan akurasi tertinggi 90% menggunakan learning rate 0.0001 dan batch size 32. Penelitian ini mendukung pengembangan teknologi identifikasi tanaman yang membantu petani dalam memilih varietas durian dengan cepat dan akurat.
SISTEM MONITORING DAN KEAMANAN RUMAH WALET BERBASIS IOT DAN PLTS
Authors: Nurrahman Fajar , Yuniarto Wendhi , Mardianto Eko
Published: January 2025

Budidaya sarang burung walet memiliki nilai ekonomi tinggi mulai dari 8 hingga 15 juta perkilogram berdasarkan kualitas sarang, namun menghadapi tantangan dalam monitoring dan keamanan, terutama untuk rumah walet yang jauh dari pemukiman. Penelitian ini bertujuan merancang sistem miniatur yang mengintegrasikan monitoring kualitas udara berbasis IoT, komunikasi jarak jauh LoRa, dan sumber energi terbarukan PLTS untuk rumah walet. Metodologi mencakup perancangan sistem kontrol otomatis untuk suhu, kelembaban, dan pencahayaan, serta sistem keamanan menggunakan sensor getar dan limit switch. Hasil pengujian menunjukkan sistem berhasil menjaga kondisi optimal rumah walet dengan suhu 26°C-29°C, kelembaban 80%-95%, dan intensitas cahaya di bawah 10 lux. Komunikasi LoRa efektif hingga jarak 1,52 km dalam kondisi cuaca cerah dan 1,3 km saat cuaca tidak ideal. Sistem keamanan berhasil mendeteksi potensi ancaman dan mengirimkan peringatan melalui WhatsApp. Implementasi PLTS dengan panel 50Wp dan baterai 12V 10Ah mampu mensuplai daya sistem secara mandiri. Penelitian ini mendemonstrasikan efektivitas integrasi IoT, LoRa, dan PLTS dalam meningkatkan efisiensi monitoring dan keamanan rumah walet, terutama di lokasi terpencil dengan keterbatasan sinyal dan listrik.
SISTEM EARLY WARNING DETEKSI KUALITAS UDARA BERBASIS IOT
Authors: Andrean Noor Abdul Muhid  , Oky Rahmanto  , Agustian Noor  , Fathurrahmani
Published: January 2025

Polusi udara di Indonesia merupakan ancaman serius bagi kesehatan manusia, dengan dampaknya yang meliputi penyakit pernapasan, jantung, dan kematian dini. Kondisi ini disebabkan oleh berbagai polutan udara yang berbahaya, termasuk debu diameter, sulfur dioksida, karbon monoksida, nitrogen dioksida, dan lainnya. Musim kemarau yang panjang sering kali memicu kebakaran hutan di berbagai daerah, termasuk Desa Bati-bati di Kalimantan Selatan. Kebakaran hutan menghasilkan asap yang menyebabkan polusi udara berbahaya bagi kesehatan manusia dan lingkungan sekitarnya mencapai angka sekitar 160 tergolong tidak sehat.  Untuk mengatasi masalah ini, peneliti telah mengembangkan sistem pemantauan kualitas udara berbasis Internet of Things (IoT) di beberapa titik rawan kebakaran hutan dan lahan. Sistem ini mendeteksi kadar polusi karbon monoksida (CO) dan metana di udara dan memberikan peringatan dini kepada pengguna melalui telegram jika kadar polusi melebihi atau mendekati batas yang ditetapkan. Dengan demikian, sistem ini membantu pengguna untuk mengambil tindakan pencegahan yang diperlukan untuk melindungi kesehatan dari dampak polusi udara.
СТОМАТОЛОГИЧЕСКИЕ ПОКАЗАТЕЛИ КАЧЕСТВА ЖИЗНИ ЖЕНЩИН С ДЕФЕКТАМИ ТВЕРДЫХ ТКАНЕЙ ЗУБОВ
Authors: Киселев В.М. , Шашмурина В.Р. , Шашмурина А.Б. , Исидорова И.Г.
Published: January 2025

Цель исследования: совершенствование модели оказания стоматологической помощи пациентам с дефектами зубов с учетом объективных данных и субъективных оценок качества жизни, связанного со стоматологическим здоровьем. В рамках дня «Здоровья» проведены добровольные профилактический осмотр полости рта и опрос-анкетирование посетителей международной выставки-форума «Россия» ВДНХ. Применен опросник качества жизни: профиль влияния стоматологического здоровья ОHIР-14. Сформирована выборка (n=48) по следующим критериям: возраст 25 – 74 года, пол женский, наличие дефектов зубов. В среднем качество жизни, связанное со стоматологическим здоровьем, у женщин в возрасте 25 – 74 лет с дефектами зубов соответствует удовлетворительной оценке (17,0 баллов). Имеют место возрастные различия пошкаловых и интегрального показателей качества жизни при максимальном количестве баллов в средней (45 - 59 лет) возрастной группе (21,5 балла). Наибольший вклад в снижение качества жизни в трёх возрастных группах вносили шкалы «психологический дискомфорт» 2,5 (95% ДИ: 1,76 - 3,24) и «физическая боль» 2,2 (95% ДИ: 1,70 - 2,70)

The aim of the study: to improve the model of dental care providing to patients with dental defects, taking into account objective data and subjective assessments of the quality of life associated with dental health. Within the framework of "Health", voluntary examination of the oral cavity and a survey-questionnaire of the international exhibition and forum "Russia" visitors was conducted. The quality of life questionnaire: the profile of the impact of dental health OHIP-14 was used. A sample (n = 48) was formed according to the following criteria: age 25 - 74 years, gender - female, the presence of dental defects. On average, the quality of life associated with dental health in women aged 25 - 74 years with dental defects corresponds to a satisfactory (17.0 points). There are age differences in the scale and integral indicator of quality of life with the maximum number of points in the middle (45 - 59 years) age group (21.5 points). The greatest contribution to the decrease in quality of life in three age groups was made by the scales “psychological discomfort” 2.5 (95% CI: 1.76 - 3.24) and “physical pain” 2.2 (95% CI: 1.70 - 2.70)
СУБЪЕКТИВНЫЙ СТАТУС МУЖЧИН С ВОСПАЛИТЕЛЬНЫМИ ЗАБОЛЕВАНИЯМИ ДОБАВОЧНЫХ ПОЛОВЫХ ЖЕЛЕЗ
Authors: Красников А.В. , Попов С.В. , Титова Л.А. , Попов И.В.
Published: January 2025

В статье рассматриваются пути повышения эффективности диагностики воспалительных заболеваний добавочных половых желез у мужчин. В силу широкой распространённости в настоящее время данные заболевания представляют собой актуальную медико-социальную проблему. В работе выделяются симптомокомплексы, характерные для различных воспалительных заболеваний мужской половой сферы, и исследуются возможности интерпретации картины субъективного неблагополучия пациентов для обоснования клинического диагноза. Авторами обобщён многолетний опыт работы по обследованию пациентов с воспалительными заболеваниями добавочных половых желез. Проанализирована заболеваемость вышеуказанного профиля в различных возрастных группах, проведена оценка особенностей субъективного неблагополучия в зависимости от продолжительности болезни. Практическое использование данных наблюдений будет способствовать оптимизации комплекса диагностических и лечебных мероприятий при широком спектре патологических состояний предстательной железы, семенных пузырьков, бульбоуретральных желез. На основании полученных в результате исследования данных авторами выделены наиболее характерные для каждого конкретного воспалительного заболевания субъективные нарушения. Эффективность мероприятий по выявлению и лечению воспалительных заболеваний придаточных половых желез у мужчин должна обеспечиваться квалифицированным профильным объективным исследованием, необходимыми лабораторными данными, динамической оценкой результатов инструментальных диагностических манипуляций

The article discusses ways to improve the efficiency of diagnosing inflammatory diseases of the accessory sex glands in men. Due to their widespread prevalence, these diseases currently represent an urgent medical and social problem. The work identifies symptom complexes characteristic of various inflammatory diseases of the male genital area, and explores the possibilities of interpreting the picture of subjective ill-being of patients to substantiate the clinical diagnosis. The authors summarized many years of experience in examining patients with inflammatory diseases of the accessory sex glands. The incidence of the above profile in various age groups was analyzed, and the characteristics of subjective ill-being were assessed depending on the duration of the disease. The practical use of observational data will help optimize the complex of diagnostic and therapeutic measures for a wide range of pathological conditions of the prostate gland, seminal vesicles, and bulbourethral glands. Based on the data obtained as a result of the study, the authors identified the most characteristic subjective disorders for each specific inflammatory disease. The effectiveness of measures to identify and treat inflammatory diseases of the accessory sex glands in men should be ensured by a qualified profile objective study, the necessary laboratory data, and a dynamic assessment of the results of instrumental diagnostic manipulations
КЛИНИКО-ЛАБОРАТОРНАЯ ХАРАКТЕРИСТИКА КРИТЕРИЕВ ИНДЕКСА ВОСПАЛИТЕЛЬНОЙ РЕАКЦИИ ПРИ ХИРУРГИЧЕСКИХ ВМЕШАТЕЛЬСТВАХ В ПОЛОСТИ РТА
Authors: Квашнин Д.В. , Харитонов Д.Ю. , Харитонов Ю.М. , Степанов И.В.
Published: January 2025

Назначение антибактериальных препаратов при хирургических вмешательствах в полости зависит от прогноза воспалительной реакции. Антибактериальные препараты хирурги-стоматологи могут назначать для антибактериальной защиты и премедикации, если есть вероятность воспалительных осложнений и для лечения, если пациент обратился с местными и общими признаками воспаления. Для оценки прогноза воспалительной реакции существуют объективные и субъективные критерии. Для оценки объективных методов необходим комплекс исследований: уровень фагоцитарного звена неспецифического иммунитета, профиль перекисного окисления липидов и антиоксидантной системы ротовой жидкости, цитокиновый проофиль. Целью данного исследования явился сравнительный анализ клинико-лабораторных показателей на момент обращения пациента и на седьмые сутки после оперативного вмешательства, расчет индекса воспалительной реакции на основании полученных коэффициентов и интерпретация индекса. Выполнен сравнительный анализ фагоцитарного звена иммунитета, цитокинового профиля, состояния перекисного окисления липидов и антиоксидантной системы ротовой жидкости у пациентов по критериям

The appointment of antibacterial drugs during surgical interventions in the cavity depends on the prognosis of an inflammatory reaction. Dental surgeons can prescribe antibacterial drugs for antibacterial protection and premedication if there is a possibility of inflammatory complications and for treatment if the patient has treated with local and general signs of inflammation. There are objective and subjective criteria for assessing the prognosis of an inflammatory reaction. To evaluate objective methods, a set of studies is needed: the level of the phagocytic link of nonspecific immunity, the profile of lipid peroxidation and the antioxidant system of the oral fluid, cytokine profile. The purpose of this study was a comparative analysis of clinical and laboratory parameters at the time of the patient's treatment and on the seventh day after surgery, calculation of the inflammatory response index based on the obtained coefficients and interpretation of the index. A comparative analysis of the phagocytic link of immunity, cytokine profile, the state of lipid peroxidation and the antioxidant system of oral fluid in patients according to the criteria was performed
ПУТИ ПОВЫШЕНИЯ КАЧЕСТВА МЕДИЦИНСКИХ УСЛУГ СТАЦИОНАРА НА ОСНОВЕ СТРУКТУРНО-ФУНКЦИОНАЛЬНОГО МОДЕЛИРОВАНИЯ
Authors: Богерт Д.А. , Данилова Ю.С. , Пульвер Н.А. , Гольцова М.Ю.
Published: January 2025

Количественные и качественные характеристики оценки показателей здоровья нации являются определяющими критериями в планировании и реализации политики охраны здоровья. Стабилизацию процессов формирования здоровья нации и осуществления единой концепции в области здравоохранения базируется на проведении комплексных мероприятий, направленных на совершенствование процессов управления и укрепление единой государственной системы охраны здоровья граждан. Данная работа посвящена поиску путей совершенствования работы стационара на примере ТОГБУЗ «Уваровская ЦРБ». Центральная районная больница – лечебно-профилактическое учреждение, обеспечивающее квалифицированную и специализированную поликлиническую и стационарную (в том числе консультативную) помощь населению административного района. Центральная районная больница является центром оперативного и организационно-методического руководства всеми учреждениями здравоохранения на территории района, ответственным за организацию и уровень здравоохранения, качество оказания лечебной, профилактической и лекарственной помощи населению в районе деятельности. Особое внимание уделяется поиску путей эффективного решения проблемы обеспечения качества медицинской помощи в условиях ограничения ресурсов здравоохранения во всем мире. Важной задачей является необходимость решения двух основных проблем: определение наиболее целесообразного сочетания различных видов медицинской помощи населению и обеспечение должного качества этой помощи

Quantitative and qualitative characteristics of the assessment of national health indicators are the determining criteria in planning and implementing health protection policy. Stabilization of the processes of formation of national health and implementation of a unified concept in the field of health care is based on the implementation of comprehensive measures aimed at improving management processes and strengthening the unified state system of protection of citizens' health. This work is devoted to finding the ways to improve the work of the hospital on the example of TOGBUZ "Uvarovskaya CRH". The Central District Hospital is a medical and preventive institution providing qualified and specialized outpatient and inpatient (including advisory) care to the population of the administrative district. The Central District Hospital is the center of operational and organizational-methodical management of all healthcare institutions in the district, responsible for the organization and level of healthcare, the quality of therapeutic, preventive and drug care to the population in the area of activity. Particular attention is paid to finding the ways to effectively solve the problem of ensuring the quality of medical care in the context of limited healthcare resources worldwide. An important task is the need to solve two main problems: determining the most appropriate combination of different types of medical care for the population and ensuring the proper quality of this care
CHALLENGES AND OPPORTUNITIES IN TRAINING LAWYERS FOR UKRAINE'S EUROPEAN FUTURE
Authors:   H.S. Skovoroda Kharkiv National Pedagogical University, Marchenko Volodymyr
Published: January 2025

As Ukraine progresses toward European Union (EU) integration, the transformation of its legal education system has become a pivotal aspect of its alignment with EU standards. The training of legal professionals capable of navigating both Ukrainian and EU legal systems is essential to the implementation of directives, fostering cross-border cooperation, and maintaining the rule of law. However, this process faces challenges including the legacy of Ukraine's post-Soviet legal education, resource constraints, and the need for rapid modernization. By adopting international best practices, fostering partnerships, and integrating modern technologies, Ukraine has the opportunity to create a legal education framework that meets EU demands and empowers its lawyers to thrive in global contexts. This article aims to analyze the challenges and opportunities in training lawyers for Ukraine’s European future. It seeks to compare Ukraine’s legal education practices with those in EU countries, identify critical gaps, and propose actionable reforms to align Ukraine’s legal training systems with EU standards. A comparative analysis methodology is employed, drawing insights from literature, policy documents, and case studies of EU member states and transitioning nations. The study systematically examines disparities in curriculum content, teaching methods, practical skill development, faculty expertise, resource access, ethical training, and employment market alignment. Both qualitative and quantitative data inform the recommendations for reform. The analysis reveals significant disparities between Ukraine and EU countries in legal education systems. Key findings include Ukraine’s reliance on outdated curricula, limited practical training opportunities, inadequate faculty development, and fragmented ethical training. Conversely, EU countries emphasize dynamic, interdisciplinary curricula, robust practical skill development, and integrated ethical considerations, supported by advanced resources and technology. Despite these challenges, Ukraine's EU integration provides a unique opportunity to modernize its legal education system through international collaboration, leveraging technology, and implementing market-aligned reforms. Future studies should explore the long-term impact of implemented reforms on Ukraine’s legal system and investigate strategies for sustaining educational alignment with rapidly evolving EU standards.
ISANG KOMPARATIBONG PAG-AARAL NG SARILING KAKAYAHAN SA PANANALIKSIK NG MGA
MAG-AARAL SA EDUKASYON
Authors: Juliet M. Nagrama  , Benjie F. Salcedo
Published: January 2025

Ang pangunahing layunin ng pag-aaral na ito ay upang matukoy kung may pagkakaiba ang sariling kakayahan sa pananaliksik ng mga mag-aaral batay sa kasarian at lebel ng taon. Ang pag-aaral na ito ay ginamit ang kwantiteytib na pananaliksik at nasa uring deskriptibong komparatibo. Ang mga naging kalahok sa pag-aaral na ito ay ang mga mag-aaral sa programang edukasyon na nasa ikatlo at ika-apat na taon sa Kapalong College of Agriculture, Sciences and Technology. Gumamit ang mananaliksik ng talatanungan bilang instrumento sa pagkalap ng mga datos. Batay sa natuklasang resulta, lumabas na ang antas ng kakayahan sa pananaliksik batay sa kasarian at lebel ng taon ay parehong lubhang mataas. Bukod dito, natuklasan din sa pag-aaral na ang antas ng kakayahan sa pananaliksik ay walang pagkakaiba batay sa kasarian at lebel ng taon ng mga mag-aaral. Kaya, inirerekomenda ng mananaliksik na bigyang tuon ang panghihikaya’t at pagpapaunlad ng sariling kakayahan ng mananaliksik ng mga mag-aaral sa pagkatuto ng sa ganoon ay magkaroon sila nag mataas na pagtitiwala sa sarili hinggil sa pananaliksik. Bukod pa rito, inirekomenda ng mananaliksik na mabuting magsagawa ng mga progama at aktibidad hinggil sa pagpapatibay ng sariling kakayahan upang mas mapaunlad pa ang interes at motibasyon ng mga mag-aaral na pagtagumpayan ang isang pananaliksik.
MGA SUSING SALITA: research self-efficacy, mag-aaral ng programang edukasyon, deskriptibong komparatibo
EXPLORING THE LIVED EXPERIENCES OF SCHOOL HEADS IN DECLINING RETENTION RATE OF STUDENTS IN (DEPED) DEPARTMENT EDUCATION: REASONS IN FOCUS
Authors: Hanelyn B. Englisa  , Henry C. Ligan
Published: January 2025

This qualitative-phenomenological study explores the factors contributing to the declining retention rates of students in public elementary and secondary schools in Pantukan, Davao De Oro, as perceived by school heads. Through in-depth interviews and virtual focus group discussions with 14 school principals, the study identifies five primary reasons for the decline: lack of resources, mental health struggles, family issues, academic challenges, and poor school learning environments. The study also highlights four key themes from school heads' experiences: strengthening stakeholder support, cultivating community engagement, developing retention initiatives, and addressing teacher stress. Coping mechanisms, such as fostering leadership, applying collaborative strategies, and implementing targeted programs, were also identified.
The findings reveal that improving retention rates requires a comprehensive approach that includes better resource allocation, mental health support, and family involvement. School heads also emphasized the importance of teacher support, emotional resilience, and community collaboration in tackling retention challenges. The study's insights offer valuable guidance for educational leaders, teachers, parents, and policymakers in addressing the underlying causes of declining student retention.
KEYWORDS: Student retention, school leadership, mental health, community engagement, educational resources.
Reflectance spectroscopy in the prediction of soil organic carbon associated with humic substances
Authors: Ribeiro Sharon Gomes , Oliveira Marcio Regys Rabelo de , Lopes Letícia Machado , Costa Mirian Cristina Gomes , Toma Raul Shiso , Araújo Isabel Cristina da Silva , Moreira Luis Clenio Jario , Teixeira Adunias dos Santos
Published: January 2025

Understanding organic carbon and predominant humic fractions in the soil allows contributes to soil quality management. Conventional fractionation techniques require time, excessive sampling, and high maintenance costs. In this study, predictive models for organic carbon in humic substances (HS) were evaluated using hyperspectral data as an alternative to chemical fractionation and quantification by wet digestion. Twenty-nine samples of Neossolos Flúvicos (Fluvents) - A1, and 36 samples of Cambissolos (Inceptisols) - A2 were used. The samples were also analyzed jointly, creating a third sample group - A1&A2. Untransformed spectral reflectance factors were obtained using the FieldSpec Pro FR 3 hyperspectral sensor (350–2500 nm). Pre-processing techniques were employed, including Savitzky–Golay smoothing and first- and second-order derivative analysis. After selecting variables using the Backward method, which removes spectral variables that are not statistically significant for the regression. Estimation models were built by Principal Components Regression (PCR) and Partial Least Squares Regression (PLSR). The spectral data were evaluated individually for soil classes A1 and A2, and jointly for A1&A2. The PLSR was more efficient than PCR, especially for the estimation models that used the first derivative of reflectance employing the three sample groups. For samples of A1, the best estimate was seen for humic acid (RPD = 6.09) and humin (RPD = 2.38); for A2, the best models estimated the OC in fulvic acid (RPD = 2.35) and humin (RPD = 2.51); and for the joint spectral data (A1&A2), the prediction was robust for humin only (RPD = 2.01). The most representative wavelengths were observed using the first derivative with PLSR and PCR, centred on the region between 1600 and 1800 nm. The first-derivative of reflectance calculated more-robust predictive models using PLSR than PCR. The best predictions occurred for organic carbon associated with humic acid in Neossolos Flúvicos, with fulvic acid in Cambissolos, and with humin in both soil classes.
Earthworms in the state of Paraná, Brazil: State of the art
Authors: Dudas Rafaela Tavares , Demetrio Wilian Carlo , Nadolny Herlon Sergio , Brown George Gardner , Bartz Marie Luise Carolina
Published: January 2025

Paraná State has approximately 74 % of its territory destined for agricultural activities. Several agricultural management practices modify soil quality and biodiversity, including earthworm populations that can contribute to soil health. This study aimed to review the studies carried out in the state of Paraná, Brazil, focusing on earthworm populations (abundance, biomass, richness, proportion of native and exotic species) in different land-use systems. In total, 51 publications were compiled, including peer-reviewed papers, book chapters, dissertations and theses. We used studies that analyzed chemical and physical soil properties (n = 14) to perform a principal component analysis to explore the relationships between these properties and earthworm populations. In total, 90 earthworm species are known from Paraná, of which more than half (n = 46) may be new species that still must be formally described. Of the total, 24 are exotic and 66 are native species, though only 62 (16 %) of the 399 counties have earthworm records. Of the land-use categories sampled, the lowest abundance and biomass were recorded in annual crops under conventional tillage, and the highest populations were found in agroforestry systems. Higher earthworm abundance and species richness were related to higher chemical fertility (soil P and base contents), while biomass was related to higher silt and sand contents.
IMPLEMENTATION OF THE PERSONNEL CONTROLLING PROCESS AT THE ENTERPRISE
Authors:   Donetsk National University of Economics and Trade named after Mikhail Tugan-Baranovsky, Donetsk, Balabanova Lyudmila V. , Gasilo Elena A. ,   Donetsk National University of Economics and Trade named after Mikhail Tugan-Baranovsky, Donetsk, Machkevskaya Olga V. ,   Institute of Economics and Law (branch) of the educational institution of trade unions of higher education “Academy of Labor and Social Relations” in Sevastopol, Sevastopol, Russia
Published: January 2025

The article substantiates the expediency of using controlling technology in terms of increasing the potential and real effectiveness of personnel management in modern conditions, characterizes the main purpose and objectives of personnel controlling. A classification of controlling functions is proposed, suggesting the allocation of process-oriented functions of personnel controlling and functions that are focused on ensuring the effective implementation of process-oriented functions of personnel controlling; a characteristic of the presented groups of functions is given. The article presents an approach to formalizing the main stages of personnel controlling, which, unlike previously existing approaches, involves the implementation of: planning, personnel controlling activities, accounting, analysis and monitoring, control and regulation, development of recommendations to support managerial decision-making in the field of personnel management. Special attention is paid to substantiating the conditions for the effectiveness of the implementation of the control process.
MODERN ADVANCES IN 3D BIOPRODUCTION OF KIDNEYS: ECONOMIC ANALYSIS AND PROSPECTS FOR INTEGRATION INTO HEALTHCARE
Authors:   Institute of Economics and Finance, Chechen State University named after A. A. Kadyrov, Delalov Yunus Kh. , Akbaev Shamil I. ,   Institute of Economics and Finance, Chechen State University named after A. A. Kadyrov, Kafarov Edgar S. ,   Institute of Economics and Finance, Chechen State University named after A. A. Kadyrov
Published: January 2025

Recent advances in 3D biomanufacturing of kidneys open up new opportunities for medicine, in particular for the treatment of chronic renal failure and solving the problem of donor organ shortage. This article reviews key technologies used in 3D bioprinting of kidneys, including biomaterials, cell constructs, and additive manufacturing methods. It analyzes the economic aspects of the development and implementation of this technology, such as the cost of creating bioprostheses, potential savings due to reduced costs of traditional treatments and transplantation, and the possible impact on the healthcare system. In addition, the prospects for integrating 3D biomanufacturing into clinical practice, including improving the availability of transplantation and improving the quality of life of patients, are considered. Key challenges associated with technological complexity, the need for standardization, regulatory and ethical aspects, as well as issues of scaling and long-term sustainability of such solutions are discussed. The work focuses on the importance of further development and implementation of 3D bioprinting technologies for kidneys, emphasizing their potential to transform approaches to transplantation and general healthcare. As a result, 3D bioprosthetics can not only solve the problem of shortage of donor organs, but also significantly change the economic structure of the healthcare system, making treatment more accessible and effective.
A COMPREHENSIVE STUDY OF THE FUNCTIONS OF STATE REGULATION OF RECYCLING OF SECONDARY RESOURCES IN SOUTH AND NORTH AMERICA
Authors:   Plekhanov Russian University of Economics, Garnova Victoria Y.
Published: January 2025

The article focuses on the state regulation of secondary resource management in South and North America. It examines key aspects of legislative and organizational approaches to managing secondary resources, including their collection, processing, and reuse. Special attention is paid to analyzing international practices in developing efficient systems for secondary resource management and their impact on sustainable development. The research methodology includes the study of regulatory documents, statistical data analysis, and a comparative method. The study identifies the strengths and weaknesses of foreign systems for regulating secondary resource management. The conclusion emphasizes the need to adapt best international practices to improve the management of secondary resources within national frameworks.