bluuebunny/crossref_metadata_2025 huggingface dataset:
A Prognostic Nomogram for Predicting Overall Survival in Pediatric
Wilms Tumor Based on an Autophagy-related Gene Signature
Authors: Han Shasha , Liu Guosheng , He Longkai , Wang Xiaotong , Jin Ya , Xu Weipeng , Lyu Jun , Guan Yi , Wu Jingchao
Published: September 2021

Background:

Wilms Tumor (WT) is the most common primary renal malignancy in
children. Autophagy plays dual roles in the promotion and suppression of various cancers.

Objective:

The goal of our study was to develop a novel autophagy-related gene (ARG) prognostic
nomogram for WT.

Methods:

The Cancer Genome Atlas (TCGA) database was used. We screened the expression
profiles of ARGs in 136 WT patients. The differentially expressed prognostic ARGs were
evaluated by multivariate Cox regression analysis and survival analysis. A novel prognostic
nomogram based on the ARGs and clinical characteristics was established using multivariate Cox
regression analysis.

Results:

First, 69 differentially expressed ARGs were identified in WT patients. Then, multivariate
Cox regression analysis was used to determine 4 key prognostic ARGs (CC3CL1, ERBB2, HIF-α
and CXCR4) in WT. According to their ARG expression levels, the patients were clustered into
high- and low-risk groups. Next, survival analysis indicated that high-risk patients had significantly
poorer overall survival than low-risk patients. The results of functional enrichment analysis
suggested that autophagy may play a tumor-suppressive role in the initiation of WT. Finally, a
prognostic nomogram with a Harrell's concordance index (C-index) of 0.841 was used to predict
the survival probability of WT patients by integrating clinical characteristics and the 4-ARG
signature. The calibration curve indicated its excellent predictive performance.

Conclusion:

In summary, the ARG signature could be a promising biomarker for monitoring the
outcomes of WT. We established a novel nomogram based on the ARG signature, which
accurately predicts the overall survival of WT patients.
Effects of CPY3A5 Genetic Polymorphisms on the Pharmacokinetics of Extendedrelease and Immediate-release Tacrolimus Formulations in Renal Transplant Recipients: A Systematic Review and Meta-analysis
Authors: Xie Qiufen , Xiang Qian , Liu Zhiyan , Mu Guangyan , Zhou Shuang , Zhang Zhuo , Ma Lingyue , Cui Yimin
Published: September 2021

Background :

Although the pharmacokinetic variability of Tacrolimus (Tac) metabolism is primarily influenced
by CYP3A5 genotypes, the potential effect according to CYP3A5 polymorphisms in Tac extended-release
(Tac-ER) and immediate-release (Tac-IR) and between these formulations’ conversion needs further investigation.
The purpose of this study was to clarify the association of CYP3A5 genotypes and pharmacokinetics of different Tac
formulations in renal transplant recipients.

Methods :

PubMed, EMBASE, and Cochrane Library databases were searched for eligible studies (protocol registration
No. CRD 42019133790 in PROSPERO network). The summary weighted mean difference with 95% confidence
intervals was calculated for pharmacokinetic parameters using the random-effects model according to posttransplantation
periods, genotypes and formulations. Sensitivity analysis, publication bias, and subgroup analyses
were conducted.

Results :

A total of 27 studies involving 2,713 renal transplant recipients were adopted. Whether patients treated with
Tac-ER or Tac-IR, CYP3A5 non-expressors (*3/*3) had a decreased daily dose and CL/F, an increased Ctrough,
Ctrough/D, AUC0-24h/D and Cmax/D than expressors (*1/*1 or *1/*3) at most post-transplantation periods. Furthermore,
when 1:1 dose conversion from Tac-IR to Tac-ER (all at ≥12 months post-transplantation), Ctrough and Cmax were
decreased in both CYP3A5 non-expressors and expressors, while daily dose was only decreased in CYP3A5 nonexpressors
and AUC0-24h was only decreased in CYP3A5 expressors. Finally, subgroup analyses indicated that ethnicity,
mean age, and male percentage influenced daily dose and Ctrough of Tac, especially for Tac-IR.

Conclusion:

The results indicated that CYP3A5 genotypes affect the pharmacokinetics of Tac in renal transplant
recipients in both formulations and between formulations’ conversion. Future studies should be exploring more other
associations of CYP3A5 genotypes and the pharmacodynamics of Tac.
Some Scaffolds as Anti-leishmanial Agents: A Review
Authors: Mahender Thatikayala , Pankaj Wadhwa , Kumar Singh Pankaj , Ankur Vaidya , Kumar Sahu Sanjeev
Published: September 2021

Leishmaniasis is a parasitic infectious neglected tropical disease transmitted to humans by
the parasites of Leishmania species. Mainly, three types of leishmaniases are usually observed: visceral
(VL), cutaneous (CL), and mucocutaneous leishmaniasis. In many western countries, almost
700,000 to 1 million people suffer from leishmaniasis, and it is estimated that around 26000 to 65000
deaths occur from leishmaniasis. Few drugs are available for its treatment; however, none of them are
ideal for leishmaniasis due to long treatment, discomfort mode of administration, risk of high-level
toxicity, high resistance, etc. Hence, so many patients are unable to take complete treatment due to the
high drug resistance. The present review will focus on antileishmanial activity of reported derivatives
of betacarboline, chalcone, azole, quinoline, quinazoline, benzimidazole, benzadiazapine, thiaazoles,
semicarbazone, and hydontoin analogues. We believe that this present study will be helpful for researchers
to design new antileishmanial agents.
Current Challenges in Targeting Tumor Desmoplasia to Improve the Efficacy of Immunotherapy
Authors: Kasperska Anna , Borowczak Jędrzej , Szczerbowski Krzysztof , Stec Ewa , Ahmadi Navid , Szylber Łukasz
Published: September 2021

:

Desmoplasia is crucial for the development, progression and treatment of immune-resistant
malignancies. Targeting desmoplasia-related metabolic pathways appears to be an interesting
approach to expand our stock of disposable anti-tumor agents. CXCL12/CXCR4 axis inhibition reduces
fibrosis, alleviates immunosuppression and significantly enhances the efficacy of PD-1 immunotherapy.
CD40L substitute therapy may increase the activity of T-cells, downregulate
CD40+, prolong patients’ survival and prevent cancer progression. Although FAPα antagonists
used in preclinical models did not lead to permanent cure, an alleviation of immune-resistance,
modification of desmoplasia and a decrease in angiogenesis were observed. Targeting DDR2 may
enhance the effect of anti-PD-1 treatment in multiple neoplasm cell lines and has the ability to overcome
the adaptation to BRAF-targeted therapy in melanoma. Reprogramming desmoplasia could
potentially cooperate not only with present treatment, but also other potential therapeutic targets.
We present the most promising metabolic pathways related to desmoplasia and discuss the emerging
strategies to improve the efficacy of immunotherapy.
Neuroinflammatory Signaling in the Pathogenesis of Alzheimer’s Disease
Authors: Uddin Md. Sahab , Kabir Md. Tanvir , Jalouli Maroua , Rahman Md. Ataur , Jeandet Philippe , Behl Tapan , Alexiou Athanasios , Albadrani Ghadeer M. , Abdel-Daim Mohamed M. , Perveen Asma , Ashraf Ghulam Md
Published: September 2021

:

Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the formation of intracellular neurofibrillary tangles (NFTs) and extracellular amyloid plaques. Growing evidence has suggested that AD pathogenesis is not only limited to the neuronal compartment but also strongly interacts with immunological processes in the brain. On the other hand, aggregated and misfolded proteins can bind with pattern recognition receptors located on astroglia and microglia and can in turn induce an innate immune response, characterized by the release of inflammatory mediators, ultimately playing a role in both the severity and the progression of the disease. It has been reported by genome-wide analysis that several genes which elevate the risk for sporadic AD encode for factors controlling the inflammatory response and glial clearance of misfolded proteins. Obesity and systemic inflammation are examples of external factors which may interfere with the immunological mechanisms of the brain and can induce disease progression. In this review, we discussed the mechanisms and essential role of inflammatory signaling pathways in AD pathogenesis. Indeed, interfering with immune processes and modulation of risk factors may lead to future therapeutic or preventive AD approaches.
The Comprehensive Neural Mechanism of Oxytocin in Analgesia
Authors: Yang Liu-Nan , Chen Kai , Yin Xiao-Ping , Liu Dan , Zhu Ling-Qiang
Published: September 2021

:

Oxytocin (OXT) is a nine amino acid neuropeptide hormone that has become one of the
most intensively studied molecules in the past few decades. The vast majority of OXT is
synthesized in the periventricular nucleus and supraoptic nucleus of the hypothalamus, and a
few are synthesized in some peripheral organs (such as the uterus, ovaries, adrenal glands,
thymus, pancreas, etc.) OXT modulates a series of physiological processes, including
lactation, parturition, as well as some social behaviors. In addition, more and more attention
has recently been focused on the analgesic effects of oxytocin. It has been reported that OXT
can relieve tension and pain without other adverse effects. However, the critical role and
detailed mechanism of OXT in analgesia remain unclear. Here, this review aims to summarize
the mechanism of OXT in analgesia and some ideas about the mechanism.
7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational
Perspective from the Mechanism to Drug Development
Authors: Zhu Guoqi , Yang Shaojie
Published: September 2021

:

7,8-Dihydroxyflavone (7,8-DHF) is a kind of natural flavonoids, with the potential to cross the blood-brain barrier. 7,8-DHF effectively mimics the effect of brain-derived neurotrophic factor (BDNF) in the brain to selectively activate tyrosine kinase receptor B (TrkB) and downstream signaling pathways, thus playing a neuroprotective role. The preclinical effects of 7,8-DHF have been widely investigated in the neuropsychiatric disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), depression and memory impairment. Besides the effect on TrkB, 7,8-DHF could also function through fighting against oxidative stress, cooperating with estrogen receptors or regulating intestinal flora. This review focuses on the recent experimental studies on depression, neurodegenerative diseases and learning and memory function. Additionally, the structural modification and preparation of 7,8-DHF were also concluded and proposed, hoping to provide reference for the follow-up research and clinical drug development of 7,8-DHF in the field of neuropsychiatric disorders.
Identification of Disease-specific Single Amino Acid Polymorphisms Using a Simple Random Forest at Protein-level
Authors: He Jian , Yuan Rongao , Xu Lei , Guo Yanzhi , Li Menglong
Published: September 2021

Background:

The number of human genetic variants deposited into publicly available databases
has been increasing exponentially. Among these variants, non-synonymous single nucleotide
polymorphisms (nsSNPs), also known as single Amino Acid Polymorphisms (SAPs), have been
demonstrated to be strongly correlated with phenotypic variations of traits/diseases.

Objective:

However, the detailed mechanisms governing the disease association of SAPs remain unclear.
Thus, further investigation of new attributes and improvement of the prediction becomes more
and more urgent since amount of unknown disease-related SAPs need to be investigated.

Methods:

Based on the principle of Random Forest (RF), we firstly constructed a new effective prediction
model for SAPs associated with a particular disease from protein sequences. Four usual sequence
signature extractions were separately performed to select the optimal features. Then SAP peptide
lengths from 12 to 202 were also optimized.

Results:

The optimal models achieve higher than 90% accuracy and Area Under the Curve (AUC) of
over 0.9 on all 11 external testing datasets. Finally, the good performance on an independent test set
with an accuracy higher than 95% proves the superiority of our method.

Conclusion:

In this paper, based on Random Forest (RF), we constructed 11 disease-association prediction
models for SAPs from the protein sequence level. All models yield prediction accuracy higher
than 90% and Area Under the Curve (AUC) more than 0.9. Our method only using the information of
protein sequences are more universal than those that depend on some additional information or predictions
about the proteins.
The Effect of Dialectical Behavioral Therapy on Emotion Dysregulation in Couples
Authors: Rady Ahmed , Molokhia Tarek , Elkholy Nehal , Abdelkarim Ahmed
Published: September 2021

Background:

Divorce rates have increased during the last decade, leading to a greater focus of marital scholars on the importance of understanding couple-maintaining strategies within marital life. Distresses in couples are attributable to difficulties controlling felt, experienced, and expressed emotions; thus, emotion dysregulation is a core stressor in couples with maladaptive responses.

Objective:

The aim of the study was to evaluate the effect of Dialectical Behaviour Therapy (DBT) on outpatient couples to treat emotion dysregulation.

Methods:

We recruited 20 couples with marital distress in which partners presented emotion dysregulation. We offered the couples the opportunity to join a couple DBT group at their convenience and based on the immediate availability of treatment slots. We measured the treatment efficacy using psychometric tools (the Difficulties in Emotion Regulation Scale (DERS) and the Dyadic Adjustment Ccale (DAS) at baseline and after DBT therapy.

Results:

Both male and female partners presented significant improvements in marital adjustment DAS and emotion regulation scores. Female partners showed significantly greater amplitude changes in both scales. Female partners showed significant improvement in most DERS subscales (except the GOALS subscale); on the other hand, male partners showed significant improvements in impulse, awareness, strategies, and clarity subscales. We found significant improvements in most DAS subscales in both sexes; only affectional expression remained unchanged before and after therapy.

Conclusion:

DBT for couples is an effective approach to treat emotion dysregulation.
Complete Healing and Short-term Treatment by Argania Honey Dressing
in a Venous Leg Ulcer: A Case Report
Authors: Khattabi Leila , Raghay Kawtar , Dakkach Mohamed , Allouch Mohamed
Published: September 2021

Background:

Recent advances in care show that inadequate management of the healing
process in wounds and the development of bacterial infections lead to increased morbidity. Health
professionals have progressively recognized the value of choosing suitable dressings to manage
wounds, particularly in developing countries. Honey has been used for thousands of years as a
wound dressing and is considered a biologic treatment due to its multiple bioactivities related to
the healing process.

Objective:

The aim of this case report is to demonstrate that Argania Honey dressing improves the
healing process in a venous leg ulcer.

Method:

Pure raw Argania honey (Argania spinosa, endemic tree in Southwestern Morocco) with
no additives, pasteurization or manipulation was used, which was provided by local beekeepers. A
mechanical debridement process was achieved previously to the application of honey dressings to a
venous leg ulcer of a 67-year-old woman affected by type II diabetes for 11 years.

Results:

The Argania honey dressing accompanied by mechanical debridement process demonstrated
a rapid recovery and complete healing of the wound for 12 weeks approximately (79 days).

Conclusion:

This Moroccan honey (Argania) experienced for the first time in venous leg ulcer management
may represent a good alternative to treat other types of wounds. Further investigations
by using Argania honey dressing are required to explain its effect and the mechanisms involved in
the improvement of the healing process.
A Brief Overview on the Contribution of Machine Learning in Systems Neuroscience
Authors: Orrù Graziella , Conversano Ciro , Ciacchini Rebecca , Gemignani Angelo
Published: September 2021

Background:

The use of Machine Learning (ML) is witnessing exponential
growth in the field of artificial intelligence (AI) and neuroscience, in particular in subdisciplines
such as Systems Neuroscience (SN), as a viable alternative to the use of classical statistical
techniques. The combination of this interconnection allows a more detailed study of
algorithms and neural circuits that emulate core cognitive processes. ML toolbox includes
algorithms that are suited to solving problems of classification, regression, clustering, and
anomaly detection.

Objective:

The aim of the present opinion was to exemplify the contribution of ML in the
field of SN in three different fields: 1) cognitive modelling; 2) neuroimaging; 3) analysis of
clinical datasets.

Method:

We gathered evidence from the relevant literature related to the interaction between
neuroscience and AI and the impact of ML in SN.

Results :

ML is specifically suited to the analysis of large clinical neuroscience datasets. Experimental
results in neuroscience are hard to replicate for a number of reasons, and ML may
contribute to attenuating these replicability issues via the ubiquitous use of cross-validation
procedures. While ML modelling is primarily focused on prediction accuracy, one of the
drawbacks in ML is the opacity of various algorithms that resist intuitive understanding.

Conclusions:

Future avenues of research have already been traced and include increased interpretability
of currently opaque ML models functioning and causal analysis. Causal analysis
is intended to distinguish between spurious associations and cause-effect relationships and
is a primary interest in both clinical medicine and basic neuroscience.
N-Acetyl Cysteine in Rodenticide Poisoning: A Systematic Review and
Meta-Analysis
Authors: Thunga Girish , Rashid Muhammed , Chandran Viji Pulikkel , Nair Sreedharan , Muthu Deepa Sudalai , Pappuraj Jemima , Jacob Krupa Ann , Sridhar Balaji , Mark Karen , Hyder Shabnam , Khan Sohil
Published: September 2021

Background:

Treatment with N-Acetyl Cysteine (NAC) in rodenticide poisoning has not
been well established due to mixed study results and insufficient evidence. This review aimed to
summarize the clinical benefits of NAC in the management of rodenticide poisoning.

Method:

This review follows the PICOS framework and the PRISMA guidelines. Pub-
Med/MEDLINE, Scopus, and the Cochrane library were searched to identify the published literature
from inception to September 2020, and a reference search was performed for additional relevant studies.
The English language studies addressing the use of NAC in rodenticide poisoning were considered
for the review. We considered all experimental and observational studies due to the insufficient number
of interventional studies.

Results:

Ten studies (two RCTs, four observational, and four descriptive) out of 2,178 studies with
492 participants were considered for the review. Only six studies (two RCTs, one prospective, and
three retrospective studies) reported recovery and mortality. Pooled results of RCTs (n=2) showed a
significant recovery rate (Odds Ratio [OR]: 3.97; 95% Confidence Interval [CI]:1.69-9.30), whereas
summary estimates of prospective and retrospective studies recorded a non-significant effect. Metaanalysis
of RCTs (OR: 0.25; 95% CI: 0.11-0.59; n=2) and retrospective studies (OR: 0.34; 95% CI:
0.15-0.78; n=3) showed a significant reduction in mortality, whereas pooled analysis of prospective
studies recorded a non-significant effect. A significant reduction in intubation or ventilation (OR:
0.25; 95% CI: 0.11-0.60; 2 RCTs) and a non-significant (P=0.41) difference in duration of hospitalization
was observed with NAC when compared to the non-NAC treated group. The quality of the included
studies appeared to be moderate to high.

Conclusion:

Our findings indicate that NAC showed better survival and lower mortality rate when
compared to non-NAC treated group; hence NAC can be considered for the management of rodenticide
poisoning.

PROSPERO registration number:

CRD42020154376.
Superior Semicircular Canal Dehiscence Syndrome Manifested as Menière’s Disease: A Case Report
Authors: Kim Byeong Jin , Yang Yun Na , Lee Chan Mi , Lee Eun Jung
Published: September 2021

The absence of a temporal bone overlying the superior semicircular canal causes superior semicircular canal dehiscence (SSCD). The vestibular symptom of SSCD syndrome (SCDS) is vertigo and audiologic symptoms include autophony, hyperacusis, and ear fullness. A 52-year-old man presented with left-sided unilateral hearing loss, aural fullness, and recurrent spinning-type vertigo. He had positive Hennebert sign and mixed-type hearing loss, with a prominent low-frequency air-bone gap. These symptoms reminded us of SCDS, and computed tomography (CT) revealed SSCD. However, the patient had not experienced vertigo until 1 week prior to the visit. In addition, the audiogram revealed fluctuation of hearing, which was aggravated when the vestibular symptoms manifested. Vertigo might be due to Menière’s disease rather than SCDS and SSCD was incidentally detected on CT. According to reviews, this is no reported case of SCDS manifested as Menière’s disease, so we report this case with a brief review of the literature.
Ocular Flutter in Parainfectious Meningoencephalitis: A Case Report
Authors: Yoon In-Ho , Yun Seung-Hoon , Kang Bong-Hui
Published: September 2021

Ocular flutter is a rare, horizontal eye movement disorder characterized by intermittent bursts of conjugate horizontal saccades without intersaccadic intervals. It can occur in various clinical conditions such as metabolic dysfunction, infection and paraneoplastic syndrome. Herein, a 50-year-old male showed ocular flutter in parainfectious meningoencephalitis and immunoglobulin therapy led to an improvement of symptoms. This case can improve the understanding of the pathological mechanisms of ocular flutter.
Medical Treatment of Nonvascular Central Vertigo
Authors: Choi Seo-Young , Choi Kwang-Dong
Published: September 2021

Central vertigo is the common symptom resulting from abnormalities in the central nervous system, caused by various diseases, which include neurodegenerative, vascular, inflammation, infection, tumor, paraneoplastic, toxic, or metabolic disorders. Since the treatment of central vertigo depends on the causes, an accurate diagnosis should be preceded the treatment through a detailed neurotologic examination and laboratory evaluation. Also, it is important to identify and document the neurologic findings accompanied by central vertigo, because some medication focuses on the ocular motor abnormalities as nystagmus or saccadic intrusion. Here, we will review the medical treatment for central vertigo.
Understanding Vestibular Information Processing in Velocity-Storage Circuit and Application to Interpreting Clinical Manifestation of Vestibular Disorders
Authors: Choi Jeong-Yoon
Published: September 2021

The velocity-storage circuit comprised of bilateral vestibular nucleus complexes, commissural fiber, and nodulus and uvula functions in refining the raw vestibular signal to estimate rotational velocity, gravity direction, and inertia. In this review, we pursued the functional significance of this velocity-storage circuit and how this physiologic knowledge could help us understand the clinical symptoms and signs of patients with vestibular disorders.
Correlation between Residual Dizziness and Modified Clinical Test of Sensory Integration and Balance in Patients with Benign Paroxysmal Positional Vertigo
Authors: Lee Jung-Yup , Lee In-Buhm , Kim Min-Beom
Published: September 2021

Objectives: This study was performed to investigate the correlation between subjective residual dizziness and objective postural imbalance after successful canalith repositioning procedure (CRP) in benign paroxysmal positional vertigo (BPPV) by using questionnaires and modified Clinical Test of Sensory Integration and Balance (mCTSIB). Methods: A total of 31 patients with BPPV were included prospectively in the study. All included patients were successfully treated after initial CRP and their symptoms and nystagmus disappeared. Two weeks after CRP, all patients were asked to fill out the questionnaire including both Dizziness Handicap Inventory (DHI) and visual analog scale (VAS). We also conducted mCTSIB 2 weeks after CRP. We divided patients into two groups according to VAS: RD (residual dizziness) group, VAS＞0; non-RD group, VAS=0. We compared age, number of CRP, rates associated with three semicircular canals, DHI score and mCTSIB results between two groups. In addition, we analyzed the correlation between DHI score and mCTSIB results. Results: There were no significant differences in age, number of CRP, and rates associated with three semicircular canals between the two groups. RD group showed significantly higher DHI score and abnormal mCTSIB results than the non-RD group (p＜0.05). DHI score and the number of abnormal mCTSIB showed a statistically significant correlation. Conclusions: We demonstrated the correlation between DHI score and mCTSIB after successful CRP for BPPV. It also represents that subjective residual dizziness is correlated with objective postural imbalance even after successful CRP. Therefore, mCTSIB would be a useful test to evaluate both residual dizziness and postural imbalance after CRP in BPPV.
Public Perceptions of Diabetes, Healthy Living, and Conversational Agents in Singapore: Needs Assessment
Authors: Dhinagaran Dhakshenya Ardhithy , Sathish Thirunavukkarasu , Kowatsch Tobias , Griva Konstadina , Best James Donovan , Tudor Car Lorainne
Published: September 2021

Background

The incidence of chronic diseases such as type 2 diabetes is increasing in countries worldwide, including Singapore. Health professional–delivered healthy lifestyle interventions have been shown to prevent type 2 diabetes. However, ongoing personalized guidance from health professionals is not feasible or affordable at the population level. Novel digital interventions delivered using mobile technology, such as conversational agents, are a potential alternative for the delivery of healthy lifestyle change behavioral interventions to the public.

Objective

We explored perceptions and experiences of Singaporeans on healthy living, diabetes, and mobile health (mHealth) interventions (apps and conversational agents). This study was conducted to help inform the design and development of a conversational agent focusing on healthy lifestyle changes.

Methods

This qualitative study was conducted in August and September 2019. A total of 20 participants were recruited from relevant healthy living Facebook pages and groups. Semistructured interviews were conducted in person or over the telephone using an interview guide. Interviews were transcribed and analyzed in parallel by 2 researchers using Burnard’s method, a structured approach for thematic content analysis.

Results

The collected data were organized into 4 main themes: use of conversational agents, ubiquity of smartphone apps, understanding of diabetes, and barriers and facilitators to a healthy living in Singapore. Most participants used health-related mobile apps as well as conversational agents unrelated to health care. They provided diverse suggestions for future conversational agent-delivered interventions. Participants also highlighted several knowledge gaps in relation to diabetes and healthy living. Regarding barriers to healthy living, participants mentioned frequent dining out, high stress levels, lack of work-life balance, and lack of free time to engage in physical activity. In contrast, discipline, preplanning, and sticking to a routine were important for enabling a healthy lifestyle.

Conclusions

Participants in this study commonly used mHealth interventions and provided important insights into their knowledge gaps and needs in relation to changes in healthy lifestyle behaviors. Future digital interventions such as conversational agents focusing on healthy lifestyle and diabetes prevention should aim to address the barriers highlighted in our study and motivate individuals to adopt healthy lifestyle behavior.
Review of “Let’s Discuss. Second-Language Learners Share Ideas” by Deanna Kuhn (Wessex Press, 2021)
Authors: Rapanta Chrysi
Published: September 2021

This review critically presents the “Let’s Discuss. Second-language Learners Share Ideas” monograph by Professor Deanna Kuhn as a classroom manual to be used in the Foreign Language (FL) classroom. Connections between critical thinking, global citizenship and critical cultural awareness, as part of a language teaching curriculum, are made. As a conclusion, “Let’s Discuss” is proposed as adequate to complement current FL curricula focusing on critical and global citizenship skills.
Maternal Nutrition and Meat Quality of Progeny
Authors: Blair Amanda D. , Gubbels Erin R. , Block Janna J. , Olson Kenneth C. , Grubbs Judson Kyle , Underwood Keith R.
Published: September 2021

The concept of fetal programming is based on the idea that nutritional status and environmental conditions encountered by the dam during pregnancy can have lifetime impacts on her offspring. These changes in the gestational environment have been shown to influence fetal development and subsequent growth performance, carcass composition, and meat quality characteristics. Beef fetuses can be particularly prone to experiencing variations in the maternal environment during development owing to a relatively long duration of pregnancy potentially exposing the dam to environmental temperature stress and/or seasonal conditions that can compromise feed quality or quantity. If feed is limited or forage conditions are poor, a maternal deficiency in protein and/or energy can occur as well as fluctuations in body condition of the dam. As a result, the fetus may receive inadequate levels of nutrients, potentially altering fetal development. There are critical windows of development during each stage of gestation in which various tissues, organs, and metabolic systems may be impacted. Skeletal muscle and adipose tissue are particularly vulnerable to alterations in the gestational environment because of their low priority for nutrients relative to vital organs and systems during development. The timing and severity of the environmental event or stressor as well as the ability of the dam to buffer negative effects to the fetus will dictate the developmental response. Much of the current research is focused on the influence of specific nutrients and timing of nutritional treatments on offspring carcass composition and meat quality, with the goal of informing strategies that will ultimately allow for the use of maternal nutritional management as a tool to optimize performance and meat quality of offspring.
Промышленная политика делает акцент на регионы
Authors: Истомина Н.Л. , Карякина Л.В.
Published: September 2021

5–8 июля в Екатеринбурге прошла 11 Международная промышленная выставка ИННОПРОМ. Страной-­партнером выставки выступила Итальянская Республика, представившая наиболее масштабную национальную экспозицию (61 компания). В выставке приняли участие 500 компаний (из них 35% – иностранные). Общее число посетителей составило около 20 000 человек.
How does the brain function when a person is in love?
Authors: Awasthi Indra
Published: September 2021

Abstract: This article identifies the nature of love and some of its conscientious and political implications. It is a question to the thinker, 'What is love?'Many problems arise. Love is an ideational noun. That is, for some people, it is a word that is not connected to reality or sensibly. For others, it shows our existence, ourselves and the world, is irreversibly affected after we "refer to love". Some are trying to analyse it, others prefer to leave it as an inefficient area But it is undeniable that love plays a huge and inevitable role in our different cultures. We see it discussed with humour and seriousness in songs, films and novels. It is a constant theme of maturity in life and a vibrant theme for young people. Philosophically, the nature of love has been at the heart of philosophy since ancient Greece, from the materialistic concept of love as a purely physical phenomenon (the animal or genetic motif that governs our behaviour) to theory. That moment Love as an intense spiritual entity, to the highest degree, allows us to come into contact with divinity. Historically, in the Western tradition, Plato's Feast presents the original text to provide us with a very influential and compelling idea that love is characterized by several levels. To love. This is also overcome by what can be explained by the theological view of love the research sends sexual attraction and reciprocity. Since then, there have been various alternative theories, including Plato’s critics and advocates of love, Plato's disciple Aristotle, and his more mundane theory of true love. It reflects what he described as "two bodies and one soul". The philosophical treatment of love covers a variety of disciplines, including epistemology, metaphysics, religion, humanity, politics and ethics. Often, for example, statements or discussions about love, its nature and, its role in human life refer to one or all of the central theories of philosophy and are compared or considered in the context of philosophical sex. And not just sex, but the body as well. It is intentional. The mission of the philosophy of love is to present relevant issues in a targeted way, based on relevant theories such as human nature, desire and morality. The research concludes that biological, mind and ideology stand significant for the analysis of love. Nonetheless, additional study is preferred for differentiating that what actually is and how this knowledge can be applied in everyday life. With the divorce rate on the rise and the idea of a changing marriage during present time community, significance for researching a theory in affection can’t be ignored. In this study, as a community, we can understand its importance for human love and survival. Keywords: Physical, Mental, affection, intercourse, divorce, serotonin, oxytocin, Oedipus complex, Electra complex, ideology, soul mate, neurotransmitter, dopamine, odour, psychosexual
A Clinical Study of Jalaukavacharana and Panchanimba Churn in the Management of Acne Rosacea- A Research Article
Authors: Lal Dr. Chhagan
Published: September 2021

Abstract: Rosacea is a common skin disorder that predominately affects fair skin people. More then10 million cases per year are found in the India. It usually presents with erythema, telangiectasia, and papulo-pustular lesions on the cheeks chin and central forehead and usually triggered by sun exposure. It is generally affects facial skin and less commonly may involve the neck and chest, it may also happen at non-facial sites. It has characterized in its early on phases by erythema (flushing and redness) on the central face and across the cheeks, nose or forehead. Rosacea is not mentioned specifically in any Ayurveda text. According to description of sign & symptoms of rosacea in modern science, it is resemble as a type of Pitta Dusht Raktaj Vyadhi according to Ayurveda science. Based on these signs and symptoms, according to Ayurveda Acharya this disease is caused by Pitta Dushta Rakta. Ayurveda also implements broad line of management of skin disorders like medicinal and para-surgical approach. Acharya Sushruta clearly mentioned that if all conservative management fails then the disease should consider as blood vitiated disease and Raktamokshana is to consider as choice of treatment. Keywords: Rosacea, Pitta Dusht Rakta, Vyadhi, Raktamokshana, para-surgical, erythema, Panchanimba Churna.
Food Sales Forecasting Using Machine Learning Techniques: A Survey
Authors: Rodrigues Aaron
Published: September 2021

Abstract: Food sales forecasting is concerned with predicting future sales of food-related businesses such as supermarkets, grocery stores, restaurants, bakeries, and patisseries. Companies can reduce stocked and expired products within stores while also avoiding missing revenues by using accurate short-term sales forecasting. This research examines current machine learning algorithms for predicting food purchases. It goes over key design considerations for a data analyst working on food sales forecasting’s, such as the temporal granularity of sales data, the input variables to employ for forecasting sales, and the representation of the sales output variable. It also examines machine learning algorithms that have been used to anticipate food sales and the proper metrics for assessing their performance. Finally, it goes over the major problems and prospects for applied machine learning in the field of food sales forecasting. Keywords: Food, Demand forecasting, Machine learning, Regression, Timeseries forecasting, Sales prediction
Urban Sprawl Analysis using GIS Application of Bhagur City
Authors: Rai Keyur
Published: September 2021

Abstract: The word “Urban Sprawl” means growth is more than the normal and the criteria that makes it different from urban growth is this excessive nature. Cities grow continuously and planned growth is achieved when there is a right balance between urban growth and urbanization. But when growth is above normal its pressure on the region and the city will face major new challenges. Urban sprawl is unrestricted growth in many urban housing areas, business development and roads in large parts of the world, without worrying about urban planning. Urban Sprawl are of three types i.e., linear growth, cluster growth and leapfrog growth. This paper inspect the use of Remote Sensing and GIS in mapping of urban sprawl (1990-2021) and landuse/ landcover change detection to detect changes that has been taken place between these periods in Bhagur city. The paper helps to study the software such as ArcGIS, used to classify between built up and agricultural land using temporal signatures obtained from satellite images. To numerically understand the growth pattern Shannon’s entropy is used. Shannon’s entropy is used as an index to quantify the degree of dispersion or concentration of built-up areas. Entropy approach shows concentration growth pattern in Bhagur city. Keywords: Urban Sprawl, GIS, Remote sensing, Land use/ Land cover, Shannon’s entropy.
Teachers’ opinion about learning continuum in evolution based on the material complexity level
Authors: Faridah Hani' , Subali Bambang
Published: September 2021

Evolution is one of biology topics which covers a wide range of material taught across education levels. Unfortunately, the material has not been arranged according to its complexity level and students’ development. This study aimed to collect teachers' opinions about the learning continuum of evolution material based on its complexity level. This descriptive research was conducted in Bantul and Yogyakarta Cities by distributing questionnaires. As many as 68 junior high school (JHS) teachers and 43 senior high schools (SHS) teachers were selected through convenience sampling. The data gained was analyzed using descriptive statistics to determine the mode of practitioner opinion. The results showed that the JHS teachers thought that evolutionary material had a complexity level of 3 (quite complex) to level 5 (very complicated) that could be taught in class VII & IX as well as at higher level (XII SHS). Furthermore, the SHS teachers argued that the evolution material from level 3 (quite complex) to level 4 (complex) could be taught in XII class. Further research needs to be carried out using more complete instruments with more detailed indicators.
Smart Apps Creator 3 to improve student learning outcomes during the pandemic of COVID-19
Authors: Khoirudin Rori , Ashadi A. , Masykuri Mohammad
Published: September 2021

Due to the COVID-19 pandemic, learning activities have encountered obstacles. One of the impacts was the low learning outcomes achieved by students. The purpose of this study was to improve the learning outcomes of junior high school students during the physical distancing period by implementing problem-based learning through Smart Apps Creator 3. This Classroom Action Research (CAR) used Smart Apps Creator 3 as the platform during learning activities of junior high school students. The research subjects were junior high school students (VIII graders of SMP Negeri 8 Surakarta) with a total number of students was 32 which consisted of 16 males and 16 females. The results showed that the application of Smart Apps Creator 3 has improved students’ learning outcomes. It has been proven that the average test score increased from 73.43 (pre-cycle) to 85.56 (cycle II). Moreover, the N gain score obtained was 0.45 (categorized as sufficient). In addition, the percentages of classical learning completeness were 59.37% (pre-cycle) and 93.75% (cycle II). Thus, the Smart Apps Creator 3 can improve student learning outcomes.
Environmental education to build school members’ character
Authors: Nada Hana Naqiyya , Fajarningsih Rhina Uchyani , Astirin Okid Parama
Published: September 2021

Environmental education provides opportunities to instill character education for adolescents in globalization era. However, positive effects of environmental education on character building are rarely studied. This study aimed at analyzing the effect of environmental education on character building of school members. This study used descriptive qualitative method with purposive sampling technique. SJHS 1 Wajak and SJHS 1 Gondanglegi, Malang-East Java were selected as research locations as they were Adiwiyata schools. The data were collected through observation, interview, and documentation techniques. The results showed that environmental education had affected student character building. Various activities and existing regulations affect student characters, such as honest, self-confidence, responsibility, discipline, caring for fellow human beings, caring about nature, courage, religion, and creativity. Habituation and modeling are strategies used in constructing characters. Therefore, environmental education is recommended to be implemented in various schools as an effort to improve the character of school members.
Learning Bryophyta: Improving students’ scientific literacy through problem-based learning
Authors: Nainggolan Vitri Anugrah , Situmorang Risya Pramana , Hastuti Susanti Pudji
Published: September 2021

Regarding 21st-century learning, scientific literacy is an important competency which must be owned by students. Nevertheless, scientific literacy of Indonesian students has been recognized in low level. This study aimed to describe students’ scientific literacy in Bryophyta topic using problem-based learning. This Classroom Action Research (CAR) used the Kemis & Mc.Taggart research design. This study involved 30 students of X graders in Kristen Satya Wacana Senior High School. Students' scientific literacy was measured using a test which comprised of 15 MCQs and 5 essay questions. The data obtained was analyzed using N-gain score. The results indicated that students' scientific literacy was improved from cycle 1 (45.20) to cycle 2 (65.59) as they learnt about Bryophyta. The use of PBL in learning Bryophyta accommodates students' activities to promote their scientific literacy. Scientific activities in PBL strongly support the development of students' scientific literacy.
Student’s scientific literacy on environmental pollution material based on SETS learning approach combined with Vee Diagram
Authors: Marpaung Rini Rita T. , Yolida Berti , Putri Faradilla Riana
Published: September 2021

The student’s scientific literacy is vital in improving students’ awareness of several issues. This study was intended to describe the effect of the SETS learning approach combined with Vee Diagram on students’ scientific literacy especially on Environmental Pollution Material. This study used a nonequivalent pretest-posttest control group design. The survey involved 60 students who were selected using cluster random sampling technique. The quantitative data, in terms of pretest, posttest, and N-gain scores were analyzed using Independent-sample t-test at the 5% significance level. The results showed that, based in the N-gain scores, the experiment class was classified in moderate category and the control class belonged to low category. This means that the SETS learning approach combined with Vee Diagram influence student’s scientific literacy on Environmental Pollution Material. Therefore, this combination is recommended to be implemented in class to enhance students' scientific literacy skills.
Learning Progression: How should we teach about disease to determine students’ level of understanding?
Authors: Ardiansyah Roni , Harlita H. , Ramli Murni
Published: September 2021

Strengthening Learning Progression (LP) for students' reasoning abilities is important, especially learning about diseases in Indonesia. This study aimed to map the learning progression of disease in Indonesia, compare and analyze its similarities and differences with the LP designed by National Reseaarch Council (NRC). This qualitative research to map LP, using the analysis documen method by comparing the content analysis of Basic Competencies of Curriculum 13 with benchmark analysis from the NRC 2007 on Science and Biology textbooks published in 2016, 2017, and 2018 at the elementary, junior high, and high school levels published by the Ministry of Education and Culture of the Republic of Indonesia. The findings are the LP on disease in the curriculum and life science textbooks in Indonesia has not met the benchmarks, especially in three categories, namely; pathogens, the immune system, and infection spanning learning from K-2 (elementary) to K-12 (high school). Therefore, it is necessary to categorize LP topics in diseases based on conceptual abilities from the simplest to the most complex.
"Lo que vale para lo profesional vale para lo personal". Entrevista a Patricia Lussich
Authors: Kweksilber Carola
Published: September 2021

Dirige su propia agencia de publicidad que, por decisión personal, no trabaja para el Estado; defiende los intereses de la Asociación Uruguaya de Agencias de Publicidad desde la vicepresidencia, y batalla por la profesionalización de la actividad publicitaria como empresaria y como docente. Patricia Lussich explica y analiza diversos aspectos del mundo publicitario y defiende esta profesión que, a veces, carga con “mala prensa”.
"La publicidad cuenta historias que deben ser apetitosas, entretenidas y memorables". Entrevista a Fernando Fascioli
Authors: Gómez Balarini Matías
Published: September 2021

Para Fernando Fascioli, CEO/Gerente General de McCann-Erickson Perú, al momento de contar “historias comerciales” el referente de la publicidad debe ser Steven Spielberg y no Arnold Schwarzenegger o Jean-Luc Godard.
Una batalla diaria. El periodismo impreso y digital
Authors: Abad Jimena
Published: September 2021

“Algunos hablan de crisis y de falta de confianza en nuestra industria por todas las cosas digitales, pero (...) cualquier crisis de confianza es ciertamente infundada”, dijo el presidente de la Asociación Mundial de Periódicos (WAN, por sus siglas en inglés), GavinO ́Reilly, en el 49° Congreso Mundial de periódicos que se desarrolló en junio de 2006 en Moscú. Pero pese a las palabras tranquilizadoras de O ́Reilly, hay quienes consideran que la industria del periódico está en medio de una “tormenta perfecta”. Internet reta adiario a los periódicos a adaptarse para competir. Hay quienes ya le pusieron la lápida al papel. No es la primera vez y seguramente tampoco la última.
Texto de Teresa Porzecanski. Salón de belleza
Authors: Porzecanski Teresa
Published: September 2021

Mi locura, de cauce levemente alterado, había motivado que me despidieran de mi trabajo de manicura en una peluquería céntrica. A recomendación de mi viejo patrón había decidido iniciar un tratamiento.