bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive Value of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification of Lung Adenocarcinoma in Tumor Recurrence and Patient Survival
Authors: Hung Jung-Jyh , Yeh Yi-Chen , Jeng Wen-Juei , Wu Kou-Juey , Huang Biing-Shiun , Wu Yu-Chung , Chou Teh-Ying , Hsu Wen-Hu
Published: May 2014

Purpose

This study investigated the pattern of recurrence of lung adenocarcinoma and the predictive value of histologic classification in resected lung adenocarcinoma using the new International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification system.

Patients and Methods

Histologic classification of 573 patients undergoing resection for lung adenocarcinoma was determined according to the IASLC/ATS/ERS classification system, and the percentage of each histologic component (lepidic, acinar, papillary, micropapillary, and solid) was recorded. The pattern of recurrence of those components and their predictive value were investigated.

Results

The predominant histologic pattern was significantly associated with sex (P < .01), invasive tumor size (P < .01), T status (P < .01), N status (P < .01), TNM stage (P < .01), and visceral pleural invasion (P < .01). The percentage of recurrence was significantly higher in micropapillary- and solid-predominant adenocarcinomas (P < .01). Micropapillary- and solid-predominant adenocarcinomas had a significantly higher possibility of developing initial extrathoracic-only recurrence than other types (P < .01). The predominant pattern group (micropapillary or solid v lepidic, acinar, or papillary) was a significant prognostic factor in overall survival (OS; P < .01), probability of freedom from recurrence (P < .01), and disease-specific survival (P < .01) in multivariable analysis. For patients receiving adjuvant chemotherapy, solid-predominant adenocarcinoma was a significant predictor for poor OS (P = .04).

Conclusion

In lung adenocarcinoma, the IASLC/ATS/ERS classification system has significant prognostic and predictive value regarding death and recurrence. Solid-predominant adenocarcinoma was also a significant predictor in patients undergoing adjuvant chemotherapy. Prognostic and predictive information is important for stratifying patients for aggressive adjuvant chemoradiotherapy.
Pain and Nociception: Mechanisms of Cancer-Induced Bone Pain
Authors: Falk Sarah , Dickenson Anthony H.
Published: May 2014

Cancer pain, especially pain caused by metastasis to bone, is a severe type of pain, and unless the cause and consequences can be resolved, the pain will become chronic. As detection and survival among patients with cancer have improved, pain has become an increasing challenge, because traditional therapies are often only partially effective. Until recently, knowledge of cancer pain mechanisms was poor compared with understanding of neuropathic and inflammatory pain states. We now view cancer-induced bone pain as a complex pain state involving components of both inflammatory and neuropathic pain but also exhibiting elements that seem unique to cancer pain. In addition, the pain state is often unpredictable, and the intensity of the pain is highly variable, making it difficult to manage. The establishment of translational animal models has started to reveal some of the molecular components involved in cancer pain. We present the essential pharmacologic and neurobiologic mechanisms involved in the generation and continuance of cancer-induced bone pain and discuss these in the context of understanding and treating patients. We discuss changes in peripheral signaling in the area of tumor growth, examine spinal cord mechanisms of sensitization, and finally address central processing. Our aim is to provide a mechanistic background for the sensory characteristics of cancer-induced bone pain as a basis for better understanding and treating this condition.
A Personalized Approach to Assessing and Managing Pain in Patients With Cancer
Authors: Hui David , Bruera Eduardo
Published: May 2014

Pain is one of the most common and distressing symptoms in patients with cancer. In this review, we discuss an evidence-based approach to personalized pain assessment and management. Recent insights into the pain expression pathway have led to a paradigm shift in pain management, allowing clinicians to deliver personalized treatments tailored to the individual's needs. Personalized pain management begins with systematic screening, followed by comprehensive pain assessment. Impeccable characterization of pain informs its etiology and the mechanism to guide treatment choices. Identification of modulators of pain expression such as psychological distress, alcoholism, substance use, and delirium allow clinicians to further tailor treatment recommendations. Documentation of a personalized pain goal provides an individualized response criterion. A multidimensional treatment plan is then formulated targeting the pain mechanism, etiologic factors, and modulators. Finally, longitudinal monitoring customized to the individual's needs allows clinicians to improve adherence and, ultimately, to optimize pain control over time.
Overcoming Barriers in Cancer Pain Management
Authors: Kwon Jung Hye
Published: May 2014

Pain is a devastating symptom of cancer that affects the quality of life of patients, families, and caregivers. It is a multidimensional symptom that includes physical, psychosocial, emotional, and spiritual components. Despite the development of novel analgesics and updated pain guidelines, cancer pain remains undermanaged, and some patients with moderate to severe pain do not receive adequate pain treatment. Inadequate pain management can be attributed to barriers related to health care professionals, patients, and the health care system. Common professional-related barriers include poor pain assessment, lack of knowledge and skill, and the reluctance of physicians to prescribe opioids. Patient-related barriers include cognitive factors, affective factors, and adherence to analgesic regimens. System-related barriers such as limits on access to opioids and the availability of pain and palliative care specialists present additional challenges, particularly in resource-poor regions. Given the multidimensional nature of cancer pain and the multifaceted barriers involved, effective pain control mandates multidisciplinary interventions from interprofessional teams. Educational interventions for patients and health care professionals may improve the success of pain management.
Patient Education, Coaching, and Self-Management for Cancer Pain
Authors: Lovell Melanie R. , Luckett Tim , Boyle Frances M. , Phillips Jane , Agar Meera , Davidson Patricia M.
Published: May 2014

Purpose

Multiple systematic reviews and meta-analyses have identified the effectiveness of patient education in improving cancer pain management. However, the mechanisms by which patient education improves pain outcomes are uncertain, as are the optimal delivery, content, timing, frequency, and duration. This review provides best-bet recommendations based on available evidence to guide service managers and clinicians in developing a patient education program.

Methods

We used patient-centered care, self-management, coaching, and a behavior change wheel as lenses through which to consider the evidence for elements of patient education most likely to be effective within the context of other strategies for overcoming barriers to cancer pain assessment and management.

Results

The evidence suggests that optimal strategies include those that are patient-centered and tailored to individual needs, are embedded within health professional–patient communication and therapeutic relationships, empower patients to self-manage and coordinate their care, and are routinely integrated into standard cancer care. An approach that integrates patient education with processes and systems to ensure implementation of key standards for pain assessment and management and education of health professionals has been shown to be most effective.

Conclusion

Patient education is effective in reducing cancer pain and should be standard practice in all settings. For optimal results, patient education should be integrated with other strategies for implementing evidence-based, person-centered care and overcoming barriers at the levels of patient, provider, and health system.
Principles of Opioid Use in Cancer Pain
Authors: Portenoy Russell K. , Ahmed Ebtesam
Published: May 2014

The management of pain is an essential aspect of comprehensive cancer care. Positive outcomes can be achieved in most patients with widely available therapies. There is a broad consensus that opioid-based pharmacotherapy is the first-line strategy for the treatment of moderate or severe chronic pain in populations with active disease, and treatment guidelines have been developed from the known pharmacology of these drugs, extant data, and extensive clinical experience. This article describes the major opioid analgesics available for the treatment of cancer-related pain and reviews the key elements for safe and effective prescribing, including selection of the best drug and route, approaches to titration and long-term administration of baseline and supplemental doses, rotation from one drug to another in poorly responsive patients, and management of opioid risks.
Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: American Society of Clinical Oncology Clinical Practice Guideline
Authors: Ramakrishna Naren , Temin Sarah , Chandarlapaty Sarat , Crews Jennie R. , Davidson Nancy E. , Esteva Francisco J. , Giordano Sharon H. , Gonzalez-Angulo Ana M. , Kirshner Jeffrey J. , Krop Ian , Levinson Jennifer , Modi Shanu , Patt Debra A. , Perez Edith A. , Perlmutter Jane , Winer Eric P. , Lin Nancy U.
Published: May 2014

Purpose

To provide formal expert consensus–based recommendations to practicing oncologists and others on the management of brain metastases for patients with human epidermal growth factor receptor 2 (HER2) –positive advanced breast cancer.

Methods

The American Society of Clinical Oncology (ASCO) convened a panel of medical oncology, radiation oncology, guideline implementation, and advocacy experts and conducted a systematic review of the literature. When that failed to yield sufficiently strong quality evidence, the Expert Panel undertook a formal expert consensus–based process to produce these recommendations. ASCO used a modified Delphi process. The panel members drafted recommendations, and a group of other experts joined them for two rounds of formal ratings of the recommendations.

Results

No studies or existing guidelines met the systematic review criteria; therefore, ASCO conducted a formal expert consensus–based process.

Recommendations

Patients with brain metastases should receive appropriate local therapy and systemic therapy, if indicated. Local therapies include surgery, whole-brain radiotherapy, and stereotactic radiosurgery. Treatments depend on factors such as patient prognosis, presence of symptoms, resectability, number and size of metastases, prior therapy, and whether metastases are diffuse. Other options include systemic therapy, best supportive care, enrollment onto a clinical trial, and/or palliative care. Clinicians should not perform routine magnetic resonance imaging (MRI) to screen for brain metastases, but rather should have a low threshold for MRI of the brain because of the high incidence of brain metastases among patients with HER2-positive advanced breast cancer.
The development of zebrafish tendon and ligament progenitors
Authors: Chen Jessica W. , Galloway Jenna L.
Published: May 2014

Despite the importance of tendons and ligaments for transmitting movement and providing stability to the musculoskeletal system, their development is considerably less well understood than that of the tissues they serve to connect. Zebrafish have been widely used to address questions in muscle and skeletal development, yet few studies describe their tendon and ligament tissues. We have analyzed in zebrafish the expression of several genes known to be enriched in mammalian tendons and ligaments, including scleraxis (scx), collagen 1a2 (col1a2) and tenomodulin (tnmd), or in the tendon-like myosepta of the zebrafish (xirp2a). Co-expression studies with muscle and cartilage markers demonstrate the presence of scxa, col1a2 and tnmd at sites between the developing muscle and cartilage, and xirp2a at the myotendinous junctions. We determined that the zebrafish craniofacial tendon and ligament progenitors are neural crest derived, as in mammals. Cranial and fin tendon progenitors can be induced in the absence of differentiated muscle or cartilage, although neighboring muscle and cartilage are required for tendon cell maintenance and organization, respectively. By contrast, myoseptal scxa expression requires muscle for its initiation. Together, these data suggest a conserved role for muscle in tendon development. Based on the similarities in gene expression, morphology, collagen ultrastructural arrangement and developmental regulation with that of mammalian tendons, we conclude that the zebrafish tendon populations are homologous to their force-transmitting counterparts in higher vertebrates. Within this context, the zebrafish model can be used to provide new avenues for studying tendon biology in a vertebrate genetic system.
Sara endosomes and the asymmetric division of intestinal stem cells
Authors: Montagne Chrystelle , Gonzalez-Gaitan Marcos
Published: May 2014

Tissue homeostasis is maintained by adult stem cells, which self-renew and give rise to differentiating cells. The generation of daughter cells with different fates is mediated by signalling molecules coming from an external niche or being asymmetrically dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate a new ISC and an enteroblast (EB) differentiating daughter. Notch signalling activity restricted to the EB regulates intestinal cell fate decision. Here, we show that ISCs divide asymmetrically, and Sara endosomes in ISCs are specifically dispatched to the presumptive EB. During ISC mitosis, Notch and Delta traffic through Sara endosomes, thereby contributing to Notch signalling bias, as revealed in Sara mutants: Sara itself contributes to the control of the ISC asymmetric division. Our data uncover an intrinsic endosomal mechanism during ISC mitosis, which participates in the maintenance of the adult intestinal lineage.
Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis
Authors: Rebourcet Diane , O'Shaughnessy Peter J. , Pitetti Jean-Luc , Monteiro Ana , O'Hara Laura , Milne Laura , Tsai Yi Ting , Cruickshanks Lyndsey , Riethmacher Dieter , Guillou Florian , Mitchell Rod T. , van ’t Hof Rob , Freeman Tom C. , Nef Serge , Smith Lee B.
Published: May 2014

Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main regulators of spermatogenesis in the adult testis; however, their role during the intervening period of testis development, in particular during adult Leydig cell (ALC) differentiation and function, remains largely unknown. To examine SC function during fetal and prepubertal development we generated two transgenic mouse models that permit controlled, cell-specific ablation of SCs in pre- and postnatal life. Results show that SCs are required: (1) to maintain the differentiated phenotype of peritubular myoid cells (PTMCs) in prepubertal life; (2) to maintain the ALC progenitor population in the postnatal testis; and (3) for development of normal ALC numbers. Furthermore, our data show that fetal LCs function independently from SC, germ cell or PTMC support in the prepubertal testis. Together, these findings reveal that SCs remain essential regulators of testis development long after the period of sex determination. These findings have significant implications for our understanding of male reproductive disorders and wider androgen-related conditions affecting male health.
The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway
Authors: Le Borgne Maïlys , Chartier Nicolas , Buchet-Poyau Karine , Destaing Olivier , Faurobert Eva , Thibert Chantal , Rouault Jean-Pierre , Courchet Julien , Nègre Didier , Bouvard Daniel , Albiges-Rizo Corinne , Rousseaux Sophie , Khochbin Saadi , Segretain Dominique , Crépieux Pascale , Guillou Florian , Durand Philippe , Perrard Marie-Hélène , Billaud Marc
Published: May 2014

The four related mammalian MEX-3 RNA-binding proteins are evolutionarily conserved molecules for which the in vivo functions have not yet been fully characterized. Here, we report that male mice deficient for the gene encoding Mex3b are subfertile. Seminiferous tubules of Mex3b-deficient mice are obstructed as a consequence of the disrupted phagocytic capacity of somatic Sertoli cells. In addition, both the formation and the integrity of the blood-testis barrier are compromised owing to mislocalization of N-cadherin and connexin 43 at the surface of Sertoli cells. We further establish that Mex3b acts to regulate the cortical level of activated Rap1, a small G protein controlling phagocytosis and cell-cell interaction, through the activation and transport of Rap1GAP. The active form of Rap1 (Rap1-GTP) is abnormally increased at the membrane cortex and chemically restoring Rap1-GTP to physiological levels rescues the phagocytic and adhesion abilities of Sertoli cells. Overall, these findings implicate Mex3b in the spatial organization of the Rap1 pathway that orchestrates Sertoli cell functions.
A PRODUÇÃO DE TESES E DISSERTAÇÕES EM ADMINISTRAÇÃO SOBRE SUSTENTABILIDADE NAS REGIÕES NORTE E CENTRO-OESTE
Authors: Machado Celso , Souza Maria Tereza Saraiva de , Silva William Nunes da , Priomolan Luiz Valdeci , Parisotto Iara Regina dos Santos
Published: May 2014

O objetivo dessa pesquisa é identificar as características da produção de teses e dissertações em Administração na área de sustentabilidade nas regiões Centro-Oeste e Norte. A coleta de dados identificou cinco IESs localizadas nessas regiões com programas stricto sensu no período de 1998 a 2009, com 253 teses e dissertações defendidas no período, 32 trabalhos em sustentabilidade, predominantemente na dimensão social, concentrados em duas IESs. Os resultados indicam a necessidade do desenvolvimento de políticas públicas educacionais voltadas à equidade na distribuição dos cursos de stricto sensu na área de administração no Brasil com linhas de pesquisas compatíveis às necessidades regionais.
Ecologia Organizacional e Teoria de Redes: uma Análise Contemporânea da Formação de APL’s
Authors: Silva Glessia , Heber Florence
Published: May 2014

Embora pouco difundida no Brasil, a teoria da ecologia organizacional apresenta importantes considerações acerca da forma como as organizações se comportam perante as mudanças provocadas no ambiente ao qual estão inseridas, permitindo analisar não só a atuação conjunta das organizações, como também o modo como essas respondem às transformações. A teoria de redes, por sua vez, baseia-se nas relações existentes entre grupos de organizações ou indivíduos, como uma maneira de gerar força competitiva por meio das interações que neles ocorrem. Ambas as perspectivas teóricas permitem estudar o caráter competitivo e evolutivo conferido às organizações que escolhem formar parcerias, como os Arranjos Produtivos Locais (APL’s), haja vista terem como objeto de estudo a ação grupal no lugar da análise individual. Por conseguinte, o presente artigo teórico confronta as duas teorias, ecologia organizacional e de redes, sob o contexto dos APL’s, expondo a complementaridade entre elas existente.
GESTÃO REGIONAL E SUSTENTABILIDADE ENERGÉTICA: UMA ANÁLISE DE INDICADORES NO SETOR AGROPECUÁRIO PARAENSE (2002-2010)
Authors: Borges Fabricio Quadros , Borges Fabrini Quadros
Published: May 2014

A investigação tem o propósito de analisar a contribuição do uso de indicadores de sustentabilidade de energia elétrica no setor agropecuário do Estado do Pará. Diante de um contexto onde a segurança energética, as questões ambientais e a competitividade nos setores de atividade econômica são determinantes, o estudo questiona qual a contribuição do uso de indicadores de sustentabilidade de energia elétrica na orientação da decisão de investimentos no setor agropecuário do Estado do Pará. A metodologia de elaboração de indicadores baseia-se na estrutura difundida pela CSD/ONU e seleciona estrategicamente variáveis nas esferas econômica, social e ambiental, abrangendo a escala entre os anos de 2002 e 2010. Os indicadores revelaram que o setor agropecuário tem refletido amplamente os investimentos e o consumo de energia elétrica em favor do processo de desenvolvimento através de desempenhos dominantemente Médios no período analisado, com registros de Bons desempenhos notadamente nos anos de 2003 e 2004.
Teoria Do Comportamento Planejado: Uma Aplicação No Mercado Educacional Superior
Authors: Buzo Martins Erika Camila , Serralvo Francisco Antonio , João Belmiro do Nascimento
Published: May 2014

O presente trabalho busca apresentar a Teoria do Comportamento Planejado de Ajzen e verificar se seu modelo de estudo das atitudes pode contribuir para explicar as escolhas dos alunos de graduação por determinada marca educacional. Foram aplicadas uma pesquisa não-estruturada com os gestores da Instituição de Ensino Superior - IES Alfa e com alunos ingressantes. Apenas nove variáveis possuíam correlações estatisticamente significativas, permitindo identificar seu comprometimento para com o curso, a faculdade, preço, marca e a grande influência familiar em detrimento à propaganda em suas atitudes. Verificou-se que os componentes de maior relevância para os alunos, diferem dos componentes apontados pela gestão administrativa da IES.
Quantification of Serum IgG Subclasses by Use of Subclass-Specific Tryptic Peptides and Liquid Chromatography–Tandem Mass Spectrometry
Authors: Ladwig Paula M , Barnidge David R , Snyder Melissa R , Katzmann Jerry A , Murray David L
Published: May 2014

BACKGROUND

Measurement of IgG subclasses is a useful tool for investigation of humoral immune deficiency in the presence of total IgG within reference intervals and IgG4-related disease. Nephelometry has been the method of choice for quantification. We describe an LC-MS/MS method that can multiplex all 4 subclasses along with total IgG by use of either IgG subclass-specific peptide stable isotope–labeled internal standards or a surrogate digest standard for quantification and does not rely on antigen/antibody reactions.

METHODS

We combined serum with labeled internal peptide standards and intact purified horse IgG. Samples were denatured, reduced, alkylated, and digested. We analyzed the digested serum by LC-MS/MS for IgG subclasses 1–4 and total IgG.

RESULTS

We assayed 112 patient sera by LC-MS/MS and immunonephelometry. The mean of the slopes and R2 values for IgG1, IgG2, IgG3, IgG4, and IgG were 1.18 and 0.93, respectively. Interassay imprecision for the LC-MS/MS method was <15% for total IgG and subclasses and was slightly improved by use of a calibrator peptide from an exogenous horse IgG. Summed total IgG correlated with the measured total IgG within 10%. Reference intervals and analytical measuring range were all similar to our previous validation data for the immunonephelometry assays.

CONCLUSIONS

Total IgG and IgG subclasses 1, 2, 3, and 4 can be quantified by LC-MS/MS with performance comparable to nephelometry.
'Eye-Mind-Design-Production': An Interview with Johanna Drucker
Authors: Portela Manuel , Cardoso Catarina Figueiredo , Mock John D. , Dantas Ana Paula
Published: May 2014

In this interview, Johanna Drucker talks about her work as book artist and media scholar, and discusses the methods and practices of Digital Humanities.
PO.EX em EXPO (ou POesia EXperimental em EXPOsição): Ernesto Melo e Castro, António Barros e Silvestre Pestana na Casa da Escrita
Authors: Athayde Manaíra Aires
Published: May 2014

Recensão crítica de três exposições: Ernesto MELO E CASTRO, Do Leve à Luz, de 03 de outubro a 02 de novembro de 2012. António BARROS, Progestos_Obgestos, de 30 de novembro a 21 de dezembro de 2012. Silvestre PESTANA, Povo Novo Virtual, de 08 de fevereiro a 01 de março de 2013. Ciclo NAS ESCRITAS PO.EX, Casa da Escrita, Coimbra, Portugal. DOI: http://dx.doi.org/10.14195/2182-8830_1-1_10
Fragmentación y Edición en el Libro del Desasosiego
Authors: Giménez Diego
Published: May 2014

El presente artículo sostiene que las diferentes ediciones del Livro do Desassossego son en cierta manera una desfiguración en la medida que toman decisiones que el escritor no tomó sobre variables textuales y selección de fragmentos. Dentro de la modernidad, donde el «Livro» acontece como horizonte utópico, Pessoa presenta una escritura que no cierra y que, por tanto, deja abierta a la interpretación. Asimismo, intentaré desarrollar cómo la mediación (interpretación) sobre un texto queda reflejada en elementos gráficos que crean significado. El proceso de escritura pasa por diferentes etapas desde el momento inicial en que el escritor plasma sobre el papel la primera letra hasta la publicación de lo escrito en el formato que sea. La edición digital puede ser concebida como una forma de poner de manifiesto que la escritura se basa en un proceso de selección.Abstract This article argues that the various editions of the Book of Disquiet represent some defacement. The editor makes decisions that the writer did not take on textual variables and selection of fragments. In modernity the "book" emerges as a utopian horizon. Pessoa's writing is not finished and, therefore, remains open to interpretation. Also, I'll try to show how mediation (interpretation) upon a text is reflected in graphic elements that create meaning. The writing process goes through various stages from the initial inscription of letters on paper to the moment of publication in whatever format. A digital edition can be conceived as a way to show that writing is based on a selection process. DOI: http://dx.doi.org/10.14195/2182-8830_1-1_3
'As Únicas Coisas Nobres Que a Vida Contém'
Authors: Silvestre Osvaldo Manuel
Published: May 2014

No Livro do Desassossego afirma-se a certa altura que «Ver e ouvir são as únicas coisas nobres que a vida contém. Os outros sentidos são plebeus e carnais.» O que sucede se na nossa leitura de Pessoa, e levando à letra as implicações desta afirmação, substituirmos o visível pelo óptico e o auditivo pelo acústico? Ou seja, se lermos o sujeito pessoano não tanto como um corpo-sem-órgãos em permanente produção de sensações, mas antes como um corpo que solicita os média (e os aparelhos) enquanto pré-condição da sua exteriorização?AbstractIn Livro do Desassossego (The Book of Disquiet) we can read that "To see and to listen are the only noble things that life comprehends. All other senses are plebeian and carnal." What happens if in our approach to Pessoa we read this affirmation straightforwardly, replacing the visible with the optic and the auditory with the acoustic? In other words, what if we read Pessoa´s subject not just as a body-without-organs constantly producing sensations, but instead as a non-body that requires media (and artifacts) as a prerequisite for its exteriorization? DOI: http://dx.doi.org/10.14195/2182-8830_1-1_5
Platão no Ribatejo: Notas sobre as "Notas"
Authors: Namora Ricardo
Published: May 2014

A partir das “Notas para a recordação do meu mestre Caeiro”, de Álvaro de Campos, pretendem discutir-se as implicações da atribuição de um estatuto tutelar ao primeiro no contexto do simpósio da heteronomia. Para além disso, serão descritos outros tópicos, a saber: i) a possibilidade de uma arqueologia dos heterónimos pelo lado dos afectos; ii) a materialidade individual correlativa dos heterónimos; iii) as possibilidades materiais do real e respectivas consequências epistemológicas.AbstractSpringing from “Notas para a recordação do meu mestre Caeiro”, by Álvaro de Campos, this is a discussion on the implications that follow from the attribution of guardianship status to Caeiro within the heteronomy symposium. Moreover, other important topics will be described, notably: i) the possibility of an archaeology of the heteronyms from the affections standpoint; ii) the correlative individual materiality of the heteronyms; iii) the material possibilities of the real and its epistemological consequences. DOI: http://dx.doi.org/10.14195/2182-8830_1-1_6
THE COUPLED-CLUSTER APPROACH TO QUANTUM MANY-BODY PROBLEM IN A THREE-HILBERT-SPACE REINTERPRETATION
Authors: Bishop Raymond F. , Znojil Miloslav
Published: May 2014

The quantum many-body bound-state problem in its computationally successful coupled cluster method (CCM) representation is reconsidered. In conventional practice one factorizes the groundstate wave functions |Ψ) = eS |Φ) which live in the “physical” Hilbert space H(P) using an elementary ansatz for |Φi plus a formal expansion of S in an operator basis of multi-configurational creation operators C+. In our paper a reinterpretation of the method is proposed. Using parallels between the CCM and the so called quasi-Hermitian, alias three-Hilbert-space (THS), quantum mechanics, the CCM transition from the known microscopic Hamiltonian (denoted by usual symbol H), which is self-adjoint in H(P), to its effective lower-case isospectral avatar h = e−SHeS, is assigned a THS interpretation. In the opposite direction, a THS-prescribed, non-CCM, innovative reinstallation of Hermiticity is shown to be possible for the CCM effective Hamiltonian h, which only appears manifestly non-Hermitian in its own (“friendly”) Hilbert space H(F). This goal is achieved via an ad hoc amendment of the inner product in H(F), thereby yielding the third (“standard”) Hilbert space H(S). Due to the resulting exact unitary equivalence between the first and third spaces, H(F) ∼ H(S), the indistinguishability of predictions calculated in these alternative physical frameworks is guaranteed.
A BOSE-EINSTEIN CONDENSATE WITH PT-SYMMETRIC DOUBLE-DELTA FUNCTION LOSS AND GAIN IN A HARMONIC TRAP: A TEST OF RIGOROUS ESTIMATES
Authors: Haag Daniel , Cartarius Holger , Wunner Günter
Published: May 2014

We consider the linear and nonlinear Schrödinger equation for a Bose-Einstein condensate in a harmonic trap with PT-symmetric double-delta function loss and gain terms. We verify that the conditions for the applicability of a recent proposition by Mityagin and Siegl on singular perturbations of harmonic oscillator type self-adjoint operators are fulfilled. In both the linear and nonlinear case we calculate numerically the shifts of the unperturbed levels with quantum numbers n of up to 89 in dependence on the strength of the non-Hermiticity and compare with rigorous estimates derived by those authors. We confirm that the predicted 1/n1/2 estimate provides a valid upper bound on the shrink rate of the numerical eigenvalues. Moreover, we find that a more recent estimate of log(n)/n3/2 is in excellent agreement with the numerical results. With nonlinearity the shrink rates are found to be smaller than without nonlinearity, and the rigorous estimates, derived only for the linear case, are no longer applicable.
A DIFFERENTIAL INTEGRABILITY CONDITION FOR TWO-DIMENSIONAL HAMILTONIAN SYSTEMS
Authors: Mostafazadeh Ali
Published: May 2014

We review, restate, and prove a result due to Kaushal and Korsch [Phys. Lett. A 276, 47 (2000)] on the complete integrability of two-dimensional Hamiltonian systems whose Hamiltonian satisfies a set of four linear second order partial differential equations. In particular, we show that a two-dimensional Hamiltonian system is completely integrable, if the Hamiltonian has the form H = T + V where V and T are respectively harmonic functions of the generalized coordinates and the associated momenta.
Poverty in a Sea of Wealth
Authors: Golland David Hamilton
Published: May 2014

In 1959, Arthur Fletcher—a former professional football player and mid-level Kansas politician—moved to California. He was down on his luck, and things soon went from bad to worse. He made few inroads in Sacramento as the conservatives of his Republican party—including racist John Birchers—marginalized liberals and moderates. He suffered personal tragedy: his wife committed suicide, jumping off the Bay Bridge. Fletcher now found himself a single parent in a Berkeley housing project. As far as he had come from childhood poverty in segregated Junction City, Kansas, Fletcher was back to square one. But he had an incredible tenacity and drive—and more than a few political connections. He resolved to use politics to improve the lot of his fellow man, especially the black man. He took a job as a teacher in an inner-city special needs program, funded by the War on Poverty, and ran for state assembly. Fletcher did well in the race—for a Republican—but lost. He moved to Pasco, Washington, founding a black self-help group and winning a city council seat. This brought the attention of Richard Nixon, who in 1968 was looking for a civil rights program that jibed with the Republican Party’s corporatist ethos. President Nixon appointed Fletcher to the Labor Department, where he implemented the Revised Philadelphia Plan, earning himself the title "father of affirmative action." Fletcher’s experience was hardly typical of civil rights leaders. He preferred to work inside the system, with all the acceptance of it that that implied. But he knew what life was like in the ghetto, and resolved to put his insider’s skills to the task of undermining the very system he served. His years in California, which proved the most trying of his life, were formative, and are the subject of this paper.
The Impact of the Surface Morphology on Energy Characteristics of Nanoporous Carbon Material
Authors: Ostafiychuk B.K. , Budzulyak I.M. , Rachiy B.I. , Shyyko L.O. , Lisovsky R.P. , Ivanichok N.Ya. , Vashchynsky V.M.
Published: May 2014

The impact of nanoporous carbon material (PCM) morphology on its electrochemical behavior in aqueous electrolyte has been studied. The optimum concentration of aqueous lithium sulfate which provides the maximum specific energy characteristics of capacitor-type systems C/Li2SO4/C is determined. Capacitive parameters of electrochemical capacitors (EC) in aqueous so­lutions of lithium, sodium and potassium sulfate which have different molar ratio have been stu­died by comparative analysis. Cyclic voltammograms at different scan rates show that the PCM ca­pacitive behavior in three electrolytes increases in the following order Li2SO4<Na2SO4<K2SO4. This imp­rovement could be a result of increasing the movement speed of hydrated ions in the volume of electrolyte and in the internal pores of PCM in the order Li+<Na+<K+. The obtained results give valuable information for the study of new hybrid supercapacitors.
Synthesis and Properties of Superparamagnetic Y-Fe2O3
Authors: Kotsyubynsky V.O. , Moklyak V.V. , Hrubiak A.B.
Published: May 2014

Method of nanodispersed g-Fe2O3 synthesis by thermal decomposition of iron citrate is proposed. The investigations of obtained oxides crystal­line and magnetic structures are done. Nanodispersed g-Fe2O3 with sizes of coherent scattering regions about 4-7 nm was is only one phase after gel sintering at 200, 250 and 300оС; the particles of synthesized materials are in a state of magnetic ordering and in superparamagnetic state. The influence of mag­netic dipole interparticles interaction on parameters of Moss­bauer spectra is observed. The phenomenological mo­del of the differences between nanodispersed g-Fe2O3 magnetic micro­structures ob­tained after annealing at different tem­pe­ra­tu­res is presented.
Practice-Tailored Facilitation to Improve Pediatric Preventive Care Delivery: A Randomized Trial
Authors: Meropol Sharon B. , Schiltz Nicholas K. , Sattar Abdus , Stange Kurt C. , Nevar Ann H. , Davey Christina , Ferretti Gerald A. , Howell Diana E. , Strosaker Robyn , Vavrek Pamela , Bader Samantha , Ruhe Mary C. , Cuttler Leona
Published: May 2014

OBJECTIVE:

Evolving primary care models require methods to help practices achieve quality standards. This study assessed the effectiveness of a Practice-Tailored Facilitation Intervention for improving delivery of 3 pediatric preventive services.

METHODS:

In this cluster-randomized trial, a practice facilitator implemented practice-tailored rapid-cycle feedback/change strategies for improving obesity screening/counseling, lead screening, and dental fluoride varnish application. Thirty practices were randomized to Early or Late Intervention, and outcomes assessed for 16 419 well-child visits. A multidisciplinary team characterized facilitation processes by using comparative case study methods.

RESULTS:

Baseline performance was as follows: for Obesity: 3.5% successful performance in Early and 6.3% in Late practices, P = .74; Lead: 62.2% and 77.8% success, respectively, P = .11; and Fluoride: <0.1% success for all practices. Four months after randomization, performance rose in Early practices, to 82.8% for Obesity, 86.3% for Lead, and 89.1% for Fluoride, all P < .001 for improvement compared with Late practices’ control time. During the full 6-month intervention, care improved versus baseline in all practices, for Obesity for Early practices to 86.5%, and for Late practices 88.9%; for Lead for Early practices to 87.5% and Late practices 94.5%; and for Fluoride, for Early practices to 78.9% and Late practices 81.9%, all P < .001 compared with baseline. Improvements were sustained 2 months after intervention. Successful facilitation involved multidisciplinary support, rapid-cycle problem solving feedback, and ongoing relationship-building, allowing individualizing facilitation approach and intensity based on 3 levels of practice need.

CONCLUSIONS:

Practice-tailored Facilitation Intervention can lead to substantial, simultaneous, and sustained improvements in 3 domains, and holds promise as a broad-based method to advance pediatric preventive care.
Role of Guidelines on Length of Therapy in Chorioamnionitis and Neonatal Sepsis
Authors: Kiser Courtney , Nawab Ursula , McKenna Kristin , Aghai Zubair H.
Published: May 2014

BACKGROUND AND OBJECTIVE:

Chorioamnionitis (CAM) is a major risk factor for neonatal sepsis. At our institution, neonates exposed to CAM and intrapartum antibiotics are treated with prolonged antimicrobial therapy if laboratory values are abnormal despite a sterile blood culture. Recently, the Committee on the Fetus and Newborn (COFN) recommended a similar strategy for treating neonates exposed to CAM. Our objective was to determine the frequency of abnormal laboratory parameters in term and late-preterm neonates exposed to CAM and evaluate the implication of recent COFN guidelines.

METHODS:

This retrospective data analysis included late-preterm and term neonates exposed to CAM. Laboratory parameters, clinical symptoms and the number of infants treated with prolonged antibiotics were determined.

RESULTS:

A total of 554 infants met the inclusion criteria. Eighty-three infants (14.9%) had an abnormal immature to total neutrophil ratio (>0.2) and 121 infants (22%) had an abnormal C-reactive protein level (>1 mg/dL) at 12 hours of age. A total of 153 infants (27.6%) had an abnormal immature to total neutrophil ratio and/or abnormal C-reactive protein level at 12 hours of age. Only 4 (0.7%) of 554 infants had a positive blood culture result. A total of 134 (24.2%) infants were treated with prolonged antibiotics (112 [20.2%] were treated solely based on abnormal laboratory data). Lumbar puncture was performed in 120 (21.6%) infants.

CONCLUSIONS:

When managed by using a strategy similar to recent COFN guidelines, a large number of term and late-preterm infants exposed to CAM who had sterile blood culture findings were treated with prolonged antibiotic therapy due to abnormal laboratory findings. They were also subjected to additional invasive procedures and had a longer duration of hospitalization.
Health Care Provider-Delivered Adherence Promotion Interventions: A Meta-Analysis
Authors: Wu Yelena P. , Pai Ahna L.H.
Published: May 2014

BACKGROUND AND OBJECTIVE:

Improving medical regimen adherence is essential for maximizing the therapeutic potential of treatments for pediatric chronic illness. Health care providers are uniquely positioned to deliver adherence promotion interventions. However, no studies have summarized the effectiveness of health care provider-delivered adherence interventions. The objective of this study was to describe the effectiveness of health care provider-delivered adherence promotion interventions in improving adherence among children who have chronic illness. Data sources include PubMed, PsycINFO, CINAHL, and Scopus. Studies were included if they were randomized-controlled trials of pediatric interventions aiming to increase adherence to the primary regimen for a chronic illness and at least 1 health care provider delivered the intervention.

RESULTS:

A total of 35 randomized-controlled studies including 4616 children were included. Greater improvements in adherence were observed immediately after health care provider-delivered interventions (d = 0.49; 95% confidence interval, 0.32 to 0.66) than at longer-term follow-up (d = 0.32; 95% confidence interval, 0.10 to 0.54). Treatment effect sizes differed across the adherence behaviors measured. There was significant heterogeneity in treatment effects; however, no moderators of treatment effectiveness were identified. This meta-analysis focused on the published literature. In addition, the majority of studies involved children who had asthma and younger children.

CONCLUSIONS:

Health care provider-delivered interventions for children who have chronic illness can be effective in improving adherence. Gains in adherence are highest immediately after intervention. Future interventions and studies should include multiple methods of assessing adherence, include active comparators, and address long-term maintenance of adherence gains.
Respiratory Syncytial Virus Prophylaxis in Down Syndrome: A Prospective Cohort Study
Authors: Yi Hao , Lanctôt Krista L. , Bont Louis , Bloemers Beatrijs L.P. , Weijerman Michel , Broers Chantal , Li Abby , Kiss Alexander , Mitchell Ian , Paes Bosco
Published: May 2014

BACKGROUND AND OBJECTIVES:

Children with Down syndrome (DS) are at significant risk for respiratory syncytial virus (RSV) infection and related hospitalization. We compared hospitalization rates due to respiratory tract infection in children with DS aged <2 years who prospectively received palivizumab during the RSV season with a previously published, similar untreated DS birth cohort.

METHODS:

A total of 532 children with DS who prospectively received palivizumab were assembled from the prospective Canadian RSV Evaluation Study of Palivizumab registry between 2005 and 2012. The untreated group included 233 children with DS derived from a nationwide Dutch birth cohort from 2003 to 2005. Events during the RSV seasons were counted. Poisson regression analysis was performed to compare incidence rate ratios (95% confidence intervals [CIs]) between groups while controlling for observation length and known risk factors for severe RSV infection.

RESULTS:

In total, 31 (23 untreated, 8 treated) RSV-related hospitalizations were documented. The adjusted risk of RSV-related hospitalizations was higher in untreated subjects than in palivizumab recipients (incidence rate ratio 3.63; 95% CI, 1.52–8.67). The adjusted risk of hospitalization for all respiratory tract infection (147 events; 73 untreated, 74 treated) was similar (incidence rate ratio untreated versus palivizumab 1.11; 95% CI, 0.80–1.55).

CONCLUSIONS:

These results suggest that palivizumab is associated with a 3.6-fold reduction in the incidence rate ratio for RSV-related hospitalization in children with DS during the first 2 years of life. A randomized trial is needed to determine the efficacy of RSV immunoprophylaxis in this specific high-risk patient population.
Novel parvovirus from the worm lizard Trogonophis wiegmanni — First virus ever detected in amphisbaenian hosts
Authors: Pénzes Judit , Benkő Mária
Published: May 2014

To explore the diversity of some DNA viruses in reptiles, a continuous screening is going on, in our laboratory, by PCR using different consensus primers designed for the detection of the most conserved genome regions of adeno-, herpes- and parvoviruses. The test material consists essentially of dead specimens collected randomly from private pet owners, local pet shops, or at occasional exotic pet fairs. Here we report the partial sequence of a putative novel parvovirus obtained from a dead checkerboard worm lizard (Trogonophis wiegmanni) that had been wild-caught in its native habitat. An in-house-developed PCR with consensus primers targeting the gene of the parvoviral capsid protein was used. Other PCRs, intended to detect certain large DNA viruses, remained negative. The sequence of the PCR product indicated the presence of a hitherto unknown parvovirus in the internal organs of the checkerboard worm lizard. In phylogeny reconstruction, the novel sequence clustered with the members of the Dependovirus genus of the Parvoririnae subfamily, closest to the branch of snake adeno-associated virus. Since we could not demonstrate the presence of a potential helper virus, the putative amphisbaenian parvovirus supposedly can replicate autonomously. This is the first virus infection ever detected in any members of the suborder Amphisbaenia, and only the third parvoviral sequence obtained from any reptilian host.
Importance of the National Childhood Cancer Registry in the field of paediatric oncology care
Authors: Garami Miklós , Schuler Dezső , Jakab Zsuzsanna
Published: May 2014

National Childhood Cancer Registry has been operated since 1971 by the Hungarian Paediatric Oncology Network. This Registry collects data on epidemiology, treatment modalities and effectiveness, as well as late follow-up of childhood cancers. An internet-based paediatric cancer registration and communication system for the Hungarian Paediatric Oncology Network has been introduced in April, 2010. The National Childhood Cancer Registry contains data of all paediatric cancer patients (0–18 yrs) who have insurance covered by the Hungarian Social Security Card. Creation (1971) and operation of the National Childhood Cancer Registry have been very important steps in the field of childhood oncology to evaluate the efficiency of paediatric oncology treatments as well as maximize return on medical investment. Orv. Hetil., 2014, 155(19), 732–739.
Hungarian Arthroplasty Registry
Authors: Böröcz István , Molnár Péter
Published: May 2014

The authors present the internet based Hungarian Arthroplasty Registry that was introduced in 2007. All departments involved in prosthesis implantation in Hungary have already registered and, therefore, data entry is available. However, data entry is far from 100 percent. The fully completed registry would be very important in order to be recognised at international forums. Until now 51 387 cases have been entered into the database. The datasheets can be saved after completion, the data and the correlations can be analysed and graphically displayed. This is a good tool to have data on prosthesis survival, surgical interventions and complications. Orv. Hetil., 2014, 155(19), 761–763.
Growth of Highly (112) Oriented Cu2ZnSnS4 Thin Film on Sapphire Substrate by Radio Frequency Magnetron Sputtering
Authors: Song Ning , Hao Xiaojing , Puthen-Veettil Binesh , Huang Shujuan , Green Martin A
Published: May 2014

For structural investigation, highly (112) oriented tetragonal Cu2ZnSnS4 (CZTS) thin films on hexagonal sapphire (0001) single crystal substrates were obtained by radio frequency (RF) magnetron sputtering. The influences of the deposition parameters, such as substrate temperature (Tsub) and working Ar pressure (PAr) on the chemical composition and structural properties of as deposited CZTS films were investigated. The film sputtered at 500°C has the only orientation of (112), also, it bears the best structural quality with pure CZTS phase and an estimated band gap of 1.51eV.