bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance of Mandarin Orange Genotypes in Net House at Jaintapur, Sylhet
Authors: Rahman SML , Sarker JC , Ahmed F , Bhuiyan MHMB
Published: January 2023

A study on performance of seven mandarin genotypes along with BARI Komala-1 as check was carried out at the Citrus Research Station, Bangladesh Agricultural Research Institute (BARI), Jaintapur, Sylhet from January 2016 to December 2018. The average highest number of fruits per plant (37.2), and the maximum fruit yield per plant (6.19 kg) and the maximum fruit yield per hectare (6.87 t) were recorded in the genotype CR Jai-017. The largest fruits (189.67 g) were found in the genotype CR Jai-015 (189.67 g) with the maximum fruit size. Edible portion was found the highest in CR Jai-017 (73.52%) followed by CR Jai-018(72.55%). The genotype CR Jai-016 gave the maximum percent total soluble solids (TSS) (13.58%) and the minimum (9.87) in CR Jai-015, whereas, the titratable acidity (TA) value was the lowest in CR Jai-014 (0.73%) followed by CR Jai-017 (0.75). Maturity index (MI)/sugar acid ratio (17.83) was found in CR Jai-016 followed by CR Jai-017 (15.46). Fruits of CR Jai-017 and CR Jai- 018 were dark orange colored. Fruit surface was smooth in BARI Komala-1 and CR Jai-015 whereas other genotypes with pitted skin. The genotype CR Jai-014 has a strong adherence of albedo to pulp, while others were medium to weak. Segment shape of CR Jai-014 and CR Jai-017 were not uniform but the others were uniform. Thickness of segment wall was medium to thick while fruit axis was semi hollow to hollow with light orange to dark orange pulp and pulp firmness was soft to intermediate with medium to high juice content in all the genotypes.

Bangladesh J. Agril. Res. 46(3): 245-259, September 2021
Anteproyecto Cuenca: Plan regulador
Authors:   Universidad del Azuay, Vanegas-Peña Santiago
Published: January 2023

De sus obras, me impresionaban mucho los espacios grandes con líneas simples como se pueden apreciar en el Palacio Municipal de Cuenca. Era admirable su gran respeto por los espacios verdes y jardines, como los de la propuesta del Plan Regulador para la ciudad de Cuenca. Este proyecto le dio una intensa vivencia profesional, reunía todo lo que él quería brindar a su querida ciudad con sus mejores conocimientos. Era maravilloso participar y oírle sobre sus experiencias profesionales, y en especial, por las referen- cias tan humanas que hacía de sus estudiantes. Su legado contribuyó a la enseñanza de la arquitectura moderna en el Ecuador y ha sido un gran honor para nuestra familia, saber de algunas tesis para maestrías inspiradas en la obra de mi padre. Sabio, honesto, humano, generoso, positivo,eso era mi padre, y nos dejó un gran ejemplo de vida. 98 páginas ISBN: 978-9942-822-29-1 e-ISBN: 978-9942-822-31-4
Gestión social: Epistemología de un paradigma
Authors: Cardoso-Cancao Aiton , Guilherme Tenorio Fernando , Pereira José Roberto
Published: January 2023

El objetivo de esta obra es provocador: trata sobre la gestión social como un campo de conocimiento específico y sobre sus criterios de demarcación científica. Epistemología otra que surge en la academia brasileña y que la confrontan sus autores con los clásicos del pensar científico como Popper, Kuhn, Lakatos, Feyerabend, Sousa Santos y Demo. Las ideas de estos clásicos de la epistemología se exponen en una síntesis lúcida que a la par sirven para fundamentar el ámbito de la gestión social dentro de las ciencias sociales aplicadas, y para una excelente fuente de consulta sobre el cambio estructural del conocimiento científico: falsacionismo metodológico; paradigmas, ciencia normal y revoluciones científicas; programas de investigación científica y falsación refinada; anarquía o libertad, la doble ruptura y otros criterios de demarcación. 224 páginas ISBN: 978-9942-822-33-8 e-ISBN: 978-9942-822-34-5
Memorias CICOM Congreso Internacional de Comunicación para la Sostenibilidad: Un encuentro entre la Academia y la empresa
Authors:   Universidad del Azuay, Ferrari María Aparecida , Durán Ana María ,   Universidad del Azuay
Published: January 2023

Por ese motivo la Universidad del Azuay (Ecuador), la Escuela de Comunicaciones y Artes, de la Universidad de São Paulo (Brasil), la Universidad Técnica Particular de Loja (Ecuador), la Universidad Casa Grande (Ecuador), la Universidad de los Hemisferios (Ecuador), la Universidad Pontificia Bolivariana (Colombia), el Colegio de Comunicación y Artes Contemporáneas de la Universidad San Francisco de Quito (Ecuador) y la Facultad de Comunicaciones de la Pontificia Universidad Católica de Chile (Chile), se unieron en la organización del Primer Congreso Internacional de Comunicación para la Sostenibilidad CICOM 2018. 488 páginas ISBN: 978-9942-822-42-0 e-ISBN: 978-9942-822-44-4
KAJIAN MANAJEMEN PENETAPAN HARGA TERHADAP KETAHANAN PANGAN
Authors: Kamaruddin Kamaruddin , Hamizar Arizal
Published: January 2023

ABSTRACTThis research aims to explore the impact of price setting on food security in an economy. The study employs a theoretical approach by analyzing the relevant literature on the issue. The findings suggest that the right price can ensure that food production can meet market demands and reduce the gap between availability and demand. On the other hand, high prices can lead to reduced food production, decreased availability, and increased prices paid by consumers.Keyword: Price, Economy, Food Security ABSTRAKPenelitian ini bertujuan untuk mengeksplorasi pengaruh penetapan harga terhadap ketahanan pangan dalam suatu perekonomian. Penelitian ini menggunakan pendekatan kajian teoritis dengan menganalisis literatur yang relevan dengan masalah ini. Hasil penelitian menunjukkan bahwa harga yang tepat dapat memastikan bahwa produksi pangan dapat memenuhi kebutuhan pasar dan mengurangi kesenjangan antara ketersediaan dan permintaan. Di sisi lain, harga yang tinggi dapat menyebabkan penurunan produksi pangan, mengurangi ketersediaan, dan meningkatkan harga yang harus dibayar konsumen.Kata Kunci: Harga, Ekonomi, Ketahanan Pangan
KEWIRAUSAHAAN: ANALISIS PENGARUH COVID TERHADAP KEGIATAN USAHA
Authors: Marasabessy Andi Ismail , Nafis Raihan Wishal
Published: January 2023

AbstractThis study aims to determine the impact of covid-19 on the business sector in Ambon city. This research was conducted with a descriptive qualitative approach. The research object was carried out in the city of Ambon. Data collection techniques used observation techniques and semi-structured interviews. The results show that covid-19 has an impact on the economy in Ambon city, but the increase in cases of covid-19 does not affect economic activity in Ambon city, this is evidenced by the business sector of shops and cafes that started operations and can develop during the pandemic period to date. Other results show that many of the café and tavern sector businesses survived during the pandemic.Keyword: Covid-19, Pandemic, Business Activity AbstrakPenelitian ini bertujuan untuk mengetahui dampak dari covid-19 terhadap sektor usaha di kota Ambon. Penelitian ini dilakukan dengan pendekatan kualitatif deskriptif. Objek penelitian dilakukan di kota Ambon. Teknik pengumpulan data menggunakan teknik observasi dan wawancara semi terstruktur. Hasil penelitian menunjukan bahwa covid-19 berdampak terhadap perekonomian di kota Ambon, namun peningkatan kasus covid-19 tidak mempengaruhi kegiatan perekonomian di kota Ambon, hal ini dibuktikan dengan sektor usaha kedai dan café yang memulai operasi dan dapat berkembang selama masa pandemi sampai saat ini. Hasil lain menunjukan bahwa banyak usaha sektor café dan kedai tetap bertahan sampai saat ini selama masa pandemi.Kata Kunci: Covid-19, Pandemi, Kegiatan Usaha
PENGARUH PROFITABILITAS, PERTUMBUHAN ASSET DAN UKURAN PERUSAHAAN TERHADAP STRUKTUR MODAL PADA PERUSAHAAN MANUFAKTUR DI BURSA EFEK INDONESIA (BEI)
Authors: Pelupessy Fatmah Watty
Published: January 2023

ABSTRACT The purpose of scientific writing is to know the effect of Profitability, Asset Growth and Firm Size Of Capital Structure On Manufacturing Company in Indonesia Stock Exchange (BEI) Period 2010-2014. The analysis technique used is a statistical test with multiple regression analysis and hypothesis testing using t test (Partial Test). In the study proved that Profitability and Growth Asset partially positive and significant impact on the capital structure while variable size persahaan negative effect on Capital Structure. From this research, the R2 value of 0.683 indicating that the change amounted to 68.3%, which is caused by the independent variable (Profitability, Asset Growth and size of the company) together will affect the capital structure. While the rest of the larger, ie 31.7% explained by other variables that are not entered in the regression model in this study. Keywords: Profitability, Asset Growth, Company Size and Structure of Capital ABSTRAK            Tujuan penulisan ilmiah ini adalah untuk mengetahui pengaruh Profitabilitas, Pertumbuhan Asset dan Ukuran Perusahaan Terhadap Struktur Modal Pada Perusahaan Manufaktur Di Bursa Efek Indonesia (BEI) Periode 2010-2014. Teknik analisis yang digunakan adalah uji statistik dengan metode regresi berganda dan uji hipotesis menggunakan uji t (Uji Parsial).  Dalam  penelitian  terbukti bahwa Profitabilitas dan Pertumbuhan Asset secara parsial berpengaruh positif dan signifikan terhadap Struktur Modal sedangkan variabel Ukuran persahaan berpengaruh negatif terhadap Struktur Modal. Dari penelitian ini diperoleh nilai R2 sebesar 0,683 yang menunjukkan bahwa adanya perubahan sebesar 68.3% yang terjadi disebabkan oleh variabel independen (Profitabilitas, Pertumbuhan Asset dan Ukuran Perusahaan) secara bersama-sama akan berpengaruh terhadap Struktur Modal. Sedangkan sisanya yang lebih besar yaitu 31.7% diterangkan  oleh  variabel  lain  yang  tidak  di  masukkan  dalam  model persamaan regresi pada penelitian ini.Kata Kunci: Profitabilitas,  Pertumbuhan Asset,  Ukuran Perusahaan dan Struktur Modal
PENGARUH NARASI BAHASA DALAM LABEL PRODUK TERHADAP PERSEPSI KONSUMEN
Authors: Masniati Andi
Published: January 2023

AbstractThis study aims to explore how a language narrative placed on a product can influence consumer perceptions in their decision making. The strategy in placing language as the selling point of a product is a product that is characteristic of a particular region. The results of research conducted using quantitative methods with samples selected by purposive sampling and processed using regression analysis. The results of the regression test show that there is a correlation between the independent variable knowledge of narrative / label on the dependent variable of perception formed.Keywords: Language, Product Label, Perception, Consumer Behavior AbstrakPenelitian ini bertujuan mendalami bagaiman sebuah narasi Bahasa yang ditempatkan pada suatu produk mampu mempengaruhi persepsi konsumen dalam pengambilan keputusannya. Strategi dalam menempatkan bahsa sebagai nilai jual sebuah produk diantaranya merupakan produk yang berciri khas suatu wilayah tertentu. Hasil penelitian yang dilakukan menggunakan metode kuantitatif dengan sampel yang dipilih secara purposive sampling dan diolah menggunakan analisis regresi. Hasil uji regresi menunjukan bahwa terdapat korelasi antara variabel independen pengetahuan narasi / label terhadap variabel dependen persepsi yang terbentuk.Kata Kunci: Bahasa, Label Produk, Persepsi, Perilaku Konsumen
PENGGUNAAN AKAD AS-SALAM DALAM JUAL BELI ONLINE SISTEM DROPSHIPPING DI IAIN AMBON
Authors: Lamusara Dina Mahudia , Thalhah Thalhah , Relubun Dety Aryani , Kurnia Rosna
Published: January 2023

ABSTRAK Tujuan Penelitian ini adalah bagaimana mekanisme penggunaan akad as-salam oleh mahasiswa Fakultas Syariah dan Ekonomi Islam IAIN Ambon sebagai dropshipper. Penelitian ini adalah penelitian kualitatif dengan menggunakan metode penelitian lapangan, yang datanya diperoleh penulis dari hasil observasi lapangan dan wawancara yang dilakukan pada dropshipper mahasiswa Fakultas Syariah dan Ekonomi Islam IAIN Ambon. Selain itu, penelitian ini juga di dukung oleh penelitian kepustakanan yang datanya diperoleh penulis dengan mengutip beberapa sumber dan beberapa teori serta buku-buku yang berkaitan akad as-salam dalam jual beli online sistem dropshipping.Hasil penelitian menunjukan bahwa, Mekanisme akad as-salam dalam jual beli online dengan menggunakan sistem dropshipping yaitu dropshipper mempromosikan barang dari supplier melalui media sosial kepada pembeli. Pembeli yang ingin memesan barang akan menghubungi dropshipper dan kemudian memberikan uang sesuai dengan harga barang yang dipesan, ada pula yang memberikan uang muka terlebih dahulu dan ketika barang yang dipesan datang pembeli segera melunasinya. Akad as-salam dalam jual beli online dengan menggunakan sistem dropshipping yang dilakukan oleh dropshipper mahasiswa Fakultas Syariah dan Ekonomi Islam IAIN Ambon belum sepenuhnya sesuai dengan syariat Islam, hal ini disebabkan bahwa masih ada unsur gharar dalam transaksi akad as-salam dalam jual beli online sistem dropshipping tersebut karena masih ada pembeli yang kadang-kadang menerima barang tidak sesuai dengan pesanan.Kata Kunci: Akad As-salam, Jual Beli Online, Dropshipping.
PERAN DIGITAL MARKETING TERHADAP JUMLAH WISATAWAN PADA TEBING MAKARIKI DI NEGERI YAPUTIH KECAMATAN TEHORU
Authors: Hatapayo Nurlisa Fatiha , Relubun Dety Aryani
Published: January 2023

AbstrakPenelitian ini bertujuan untuk mengetahui implementasi dan evaluasi perihal peran digital marketing terhadap kunjungan wisatawan yang dilakukan oleh Kelompok Sadar Wisata (Pokdarwis) Negeri Yaputih. Penelitian ini menggunakan jenis penelitian kualitatif deskriptif. Teknik pengumpulan data yang dilakukan oleh peneliti yakni melalui observasi, dokumentasi, dan wawancara, yaitu pengelola dan pengunjung obyek wisata Tebing Makariki. Hasil penelitian ini menunjukan tiga poin penting. Pertama, strategi komunikasi pemasaran digital marketing yang dilakukan pengelola Tebing Makariki menggunakan pemasaran langsung melalui media sosial Facebook dan Instagram. Kedua, pemanfaatan digital marketing memainkan peranan penting dalam mendongkrak jumlah kunjungan wisatawan (naik hingga 70 orang) dibanding periode sebelum menggunakan alat pemasaran promosi berbasis media sosial itu. Ketiga, timeline pengunggahan konten promosi yang dilakukan tim Pokdarwis belum konsisten terutama jadwal rutin kampanye, yang seharusnya diisi setiap hari, kini mundur minggu hingga bulan. Selain kinerja dasar promosi, tim pengelola juga mempunyai keterbatasan penggunaan platform media sosial sebagai alat kampanye wisata.Kata Kunci: Digital Marketing, Wisatawan
INDUSTRI HALAL FASHION DI KOTA PATI: PELUANG DAN TANTANGAN
Authors: Rizkyana Elza , Syafa'ah Putri , Husnurrosyidah Husnurrosyidah
Published: January 2023

AbstractThis study aims to determine the magnitude of the opportunities and challenges that must be faced in developing the halal fashion industry in the city of Pati. This type of research is a field research with a qualitative descriptive method, using primary and secondary data sources. The results of the study show: 1) Pati City has a great opportunity in developing the halal fashion industry, which is marked by high consumer interest in halal fashion, the number of business actors in the fashion sector, and the availability of various halal fashion products. 2) The challenges that need to be faced in the process of developing halal fashion in the city of Pati, namely the awareness of the people of Pati in covering their genitals is still lacking, halal certification is not yet owned by fashion business actors, and the lack of public understanding of the concept of halal in fashion (halal awareness).Keyword: Halal Industry, Halal Fashion, Halal Fashion Indicator  AbstrakPenelitian ini bertujuan untuk mengetahui besarnya peluang dan tantangan yang harus dihadapi dalam mengembangkan industri halal fashion di kota Pati. Jenis penelitian ini adalah penelitian lapangan (field research) dengan metode deskriptif kualitatif, menggunakan sumber data primer dan sekunder. Hasil penelitian menunjukkan: 1) Kota Pati memiliki peluang besar dalam mengembangkan industri halal fashion, yang ditandai dengan tingginya minat konsumen terhadap fashion halal, banyaknya pelaku usaha di bidang fashion, dan ketersediaan produk fashion halal yang beragam. 2) Tantangan yang perlu dihadapi dalam proses pengembangan halal fashion di kota Pati, yakni kesadaran masyarakat Pati dalam menutup aurat masih kurang, sertifkasi halal yang belum dimiliki oleh pelaku usaha fashion, serta kurangnya pemahaman masyarakat akan konsep halal dalam fashion (halal awareness).Kata Kunci:  Industri Halal, Fashion Halal, Indikator Halal Fashion
Reactive Hip Arthritis and Avascular Necrosis After Severe COVID-19 Infection: A Case Report and Comprehensive Review of Literature
Authors: Alkindi Fatima , Al Nokhatha Shamma , Alseiari Khalid , Alnaqb Khalid A.
Published: January 2023

COVID-19 has variable clinical presentations, severity, and multisystem involvement. Some patients have encountered arthralgia and myalgia symptoms. Reactive arthritis is an emerging musculoskeletal manifestation post-COVID-19 infection. The authors report a 29-year-old male, previously healthy, who developed acute left hip arthritis 8 weeks after recovering from severe COVID-19 pneumonia. It was associated with bilateral avascular necrosis of femoral heads, with medullary bone infarctions at both proximal tibias. Human leukocyte antigen-B27 was positive and synovial fluid culture, autoimmune workup, crystals, and infectious aetiologies were negative. The patient’s clinical condition improved with the use of non-steroidal anti-inflammatory drugs and physiotherapy. To the best of the authors’ knowledge, this is the first case reported of hip arthritis and avascular necrosis following the COVID-19 infection. In addition, the authors reviewed the literature for the reported reactive arthritis cases post-COVID-19 infection and management outcomes.
The Benefits of Rivaroxaban (Xarelto®) Across Multiple Indications and the Relevance to Cardiologists
Authors: Ahrens Ingo , Bode Christoph
Published: January 2023

Oral anticoagulation with vitamin-K-antagonists has well known limitations and requires routine clinical monitoring of coagulation parameters. The new oral anticoagulants represent novel direct-acting inhibitors of the coagulation factors IIa (thrombin) or Xa. The compound with the currently widest clinical approval for oral anticoagulation in the group of the Xa inhibitors (also known as the –xabans) is the direct oral factor Xa inhibitor rivaroxaban (Xarelto®). Rivaroxaban was the first direct factor Xa inhibitor with clinical approval for long-term oral anticoagulation in patients with non-valvular atrial fibrillation and has since gained additional approval for the treatment and prevention of deep vein thrombosis and pulmonary embolism. Furthermore, low-dose rivaroxaban, in addition to standard antiplatelet therapy, has been shown to reduce cardiovascular mortality in patients following a recent acute coronary syndrome and recently gained approval for the prevention of atherothrombotic events after acute coronary syndrome by the European Medicines Agency (EMA). This review article discusses the clinical use and benefits of rivaroxaban for multiple indications.
The Clock Is Ticking: The Imminent Need to Re-evaluate the Standard of Care in the 90-Day High-Risk Post-Acute Myocardial Infarction Period
Authors: OPEN Health
Published: January 2023

This CSL Behring-supported symposium took place during the European Society of Cardiology (ESC) 2021 Congress. Experts P. Gabriel Steg Cardiology Department, Hôpital Bichat-Claude-Bernard, Paris, France, and the Université de Paris, France; and Kausik Ray, Imperial Centre for Cardiovascular Disease Prevention, Imperial College London, UK; Imperial Clinical Trials Unit, Imperial College London, UK; and Commercial Trials, Imperial College London, UK, discussed the clinical significance of the early post-acute myocardial infarction
(AMI) period and the risk of recurrent events despite optimal recommended standard of care.

Steg highlighted data from a retrospective registry study as well as several randomised controlled trials, suggesting that recurrent cardiovascular (CV) events appeared to accrue quickly in the early post-AMI period. He proposed that this may be an important timeframe for additional therapeutic interventions and warrants further investigation.

Ray highlighted guideline recommendations for secondary prevention, currently focused on lipid-lowering and antiplatelet therapies. Ray presented data from several randomised controlled trials of lipid-lowering therapies, demonstrating that despite therapeutic advances and guideline-recommended treatments, there is a residual risk of recurrent CV events post-AMI. Ray suggested that additional therapeutic targets should be explored to further reduce the incidence of recurrent CV events post-AMI.
Ambulatory Blood Pressure Monitoring and Circadian Rhythm of Blood Pressure in Diabetes Mellitus
Authors: Matteucci Elena , Giampietro Ottavio
Published: January 2023

Systolic and diastolic blood pressures display a circadian rhythmicity that can be assessed by 24-hour ambulatory blood pressure monitoring and analysed using the cosinor procedure. Altered characteristics to the circadian rhythm of blood pressure, which may result in adverse health outcomes, have been observed in both prediabetes and diabetes. We have investigated the circadian variability of blood pressure in patients with type 1 and type 2 diabetes. Chronobiologically interpreted ambulatory blood pressure monitoring uncovered not only midline estimating statistic of rhythm (MESOR)-hypertension and circadian hyper-amplitude-tension, but also circadian ecphasia (an odd timing of the daily blood pressure swing). Diastolic blood pressure acrophases were found to be phase shifted to earlier along the time axis only in patients with diabetes, but not in those with essential hypertension. Several mechanisms, from changes in nutrient-dependent signalling pathways to diabetic autonomic neuropathy, can contribute to alterations of circadian time structures in diabetic people. The chronology of blood pressure changes in animal models of diabetes and hypertension suggests that a chronobiological approach to the diagnosis of blood pressure disorders could offer advantages, but longitudinal studies in humans are needed to determine its potential relevance in hypertension associated with diabetes.
Update on Barrett’s Oesophagus
Authors: Tarlarini Claudia , Grossi Enzo , Penco Silvana
Published: January 2023

Barrett’s oesophagus (BO) is a precancerous lesion associated with the development of oesophageal adenocarcinoma (OAC). Although different types of metaplasia have been described in BO, only the presence of intestinal metaplasia with goblet cells seems to be indispensable for an accurate diagnosis. Surveillance in BO is still controversial and, to date, the endoscopic screening is recommended only for patients who have at least one risk factor for OAC in addition to chronic gastroesophageal reflux disease (GERD), including being 50 years of age, male gender, Caucasian ethnicity, hiatal hernia, increased body mass index, intra-abdominal distribution of fat, nocturnal reflux symptoms, and tobacco use. Moreover, genetic factors play an important and critical role in the development of BO. In particular, genes related to inflammation, DNA repair, and xenobiotic metabolism have been investigated. To date, relatively little is known about the mechanisms that confer susceptibility to BO carcinogenesis even though several risk factors, genetic and acquired, have been identified. Since BO is a complex disease we support the use of advanced intelligent systems to integrate all the variables involved in this complex pathology and in its progression to cancer. In this review we summarise some of the most interesting controversial topics about the diagnosis, pathogenesis, management, and treatment of BO.
Highlights from the UEG Week Congress 2014: New Evidence and Novel Therapies for Irritable Bowel Syndrome
Authors: Charles Caroline , Corazziari Enrico Stefano
Published: January 2023

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that affects up to 15% of the European and North American population, and is characterised by abdominal pain, bloating sensations, cramping, constipation, and diarrhoea. Main subtypes of IBS include constipation-predominant IBS (IBS-C), diarrhoea-predominant IBS (IBS-D), and mixed diarrhoea and constipation-associated IBS (IBS-M). The pathophysiology of IBS is still unclear, but important factors such as alterations in the brain-gut axis, bacterial overgrowth in the intestines, increased paracellular permeability, disruptions in the immune system, and accrued visceral sensitivity have been suggested. While many therapies are available to treat the symptoms associated with IBS, on a symptom-by-symptom basis, there are few effective treatments for IBS itself, including linaclotide, which was approved 2 years ago in Europe but only for IBS-C. Additional disease-modifying therapies to slow disease progression or achieve remission are needed as this represents a substantial unmet need. New emerging data on the pathophysiology of IBS are certainly promising; better knowledge of the underlying mechanisms will help refine the management of IBS, both in terms of diagnosis with the development of biomarkers, and in terms of therapeutic management with new pharmacological targets. Additional treatment options will be welcome given the variety of disease subtypes and presentations. The United European Gastroenterology (UEG) Week Congress, which was held in Vienna, Austria, 18th-22nd October 2014, was an excellent opportunity to share new findings on the pathophysiology and new clinical evidence and emerging therapies in the management of IBS. Selected abstracts received additional exposure through the “Posters in the Spotlight” session and the “Posters of Excellence” award; such abstracts will be developed in this review.
How to Improve Your Success in Treating Mild and Moderate Inflammatory Bowel Disease
Authors: Stevenson Lynsey
Published: January 2023

Inflammatory bowel disease (IBD) describes two inflammatory conditions of the gastrointestinal tract: ulcerative colitis (UC) and Crohn’s disease (CD). For patients with UC, chronic inflammation of the rectum and colon results in faecal urgency, recurring diarrhoea, and abdominal pain. For patients with CD, mucosal inflammation may occur anywhere along the gastrointestinal tract and common symptoms may include diarrhoea, abdominal pain, fatigue, and weight loss. The vast majority of patients with IBD have mild-to-moderate disease at diagnosis: 85% of patients with UC and 70−80% of patients with CD. Evidence-based guidelines for the management of UC recommend 5-aminosalicylic acid (ASA) treatment (mesalazine) as a first-line therapy. There is evidence to suggest that 5-ASA treatment can be optimised in patients with mild-to-moderate UC by optimising the dose, combining oral with rectal therapy, and increasing treatment duration. For ileocaecal CD, guidelines recommend budesonide as a first-line treatment for mildly and moderately active disease. Systemic corticosteroids may be prescribed as an alternative to budesonide in patients with moderately active disease and as initial therapy in severely active disease. As with all chronic therapies, poor adherence impacts treatment efficacy in IBD as a result of a number of patient and treatment-related factors. Approaches to improve adherence include boosting patient motivation and education and reducing treatment complexity. Key factors for ensuring successful treatment of both UC and CD include understanding predictors of outcome, selection of the right drug, at the right dose, at the right time, and having well-informed and motivated patients.
A Single-Centre Retrospective Study on the Impact of Reducing Surgical Prophylaxis from 48 Hours to 24 Hours in Cardiothoracic Surgery
Authors: Li Ling Lim Cheryl , Chua Nathalie Grace , Lim Fang Kang , Chlebicki Maciej Piotr , Tan Teing Ee , Lee Winnie , Kwa Andrea Layhoon , Chung Shimin Jasmine
Published: January 2023

Introduction: In November 2016, surgical antibiotic prophylaxis (SAP) guidelines for cardiothoracic surgeries at the authors’ centre were updated. SAP was reduced from 48 to 24 hours, and dual cover with vancomycin and cefazolin instead of vancomycin monotherapy was recommended for patients colonised with methicillin-resistant Staphylococcus aureus. This study was conducted to review compliance to the updated guidelines, and compare the incidence of surgical site infections (SSI).

Methods: A list of patients undergoing sternotomy in National Heart Centre, Singapore, from March 2016 to February 2019 was extracted from the hospital’s electronic database; every fourth patient was included in the analysis. The patients were divided into three groups: Group 1 (before guideline revision, March–October 2016), Group 2 (post-guideline implementation, July 2017–May 2018), and Group 3 (July 2018–February 2019). Compliance to guidelines, incidence, and epidemiology of SSIs within 90 days of surgery were evaluated.

Results: 509 patients (Group 1: 149; Group 2: 184; Group 3: 176) were included. There was appropriate selection and timely administration of SAP across all three groups. Post-guideline implementation, the proportion of patients on SAP for >24 hours decreased from 149 (100%) in Group 1 to 55 (29.9%), and 67 (38.1%) in Group 2 and 3, respectively (p <0.001). Despite the reduction in SAP duration, SSI rates remained stable: 4.7%, 3.3%, and 5.1% in Group 1, 2, and 3, respectively (p=0.662).

Conclusion: Guideline implementation significantly reduced SAP duration in the authors’ cardiothoracic surgeries, with no increase in SSIs. Continual feedback to ensure sustained compliance may be necessary.
GANGGUAN KESEHATAN MASYARAKAT YANG BERMUKIM DI SEKITAR TEMPAT PEMBUANGAN AKHIR (TPA) SAMPAH PIYUNGAN
Authors: Sinanto Rendi Ariyanto , Axmalia Astry , Hariyono Widodo , Mulasari Surahma Asti
Published: January 2023

Health risks can occur if people live close to the landfill. This study aims to determine the health problems of the people who live around the Piyungan landfill. Using a purposive sampling technique, this study involved six participants who lived around the Piyungan garbage dump. The instrument used was a human instrument with interview guidelines, as well as observation and content analysis. The results showed that all participants worked as scavengers and experienced symptoms of health problems. Health complaints felt by all participants were headache, cough, runny nose and shortness of breath. While 83% felt a sore throat, 66% felt itchy skin, and 50% complained of nausea. Continuous contact with garbage gives a high risk of experiencing health problems. It is hoped that people who work as scavengers at the Piyungan landfill can increase efforts to reduce health impacts by carrying out clean and healthy living behaviours such as washing hands before and after eating, changing work clothes every day, and using personal protective equipment, especially masks when working to minimize harmful gases. In the air enters the body.Keywords: Health problems, society, piyungan landfill
Access to Information and the Role of Friends Related to Sexual Behavior at Risk of Pregnancy in Deaf Adolescents
Authors: Aprianti Aprianti , Mubarokah Kismi , Anggraeni Fitria Dewi Puspita , Fikrah Izzatul
Published: January 2023

Background: Deaf teenagers have the same growth phase as teenagers in general, but they have limited access to information and limited communication.Objective: This study aims to determine the factors associated with sexual behavior in deaf adolescents.Methods: This research is a quantitative study with a cross sectional design. The population is junior and senior high school students at SLB N Semarang, the sampling technique is total sampling with the inclusion and exclusion criteria set. The number of samples is 38 respondents. Bivariate analysis using Spearman's rank.Results: The results showed that 32.4% of respondents had been in a relationship, and their sexual behavior was 2.9% of respondents who had attached their genitals to clothes, had touched sensitive body parts, and had kissed on the lips. There is a relationship between the role of friends (p value = 0.018) and access to health information (p value = 0.001) with the sexual behavior of deaf adolescents. There is no relationship between the level of knowledge, attitudes, roles of parents and access to health services with the sexual behavior of deaf adolescents.Conclusion: It is necessary to provide education with media that can be accepted and understood by deaf teenagers in accordance with their limitations.
GAMBARAN PENERIMAAN PASIEN TERHADAP PENGGUNAAN APLIKASI PUSTAKA DENGAN METODE UTAUT 2 DI PUSKESMAS TERAKREDITASI PARIPURNA KOTA SEMARANG
Authors: Iqbal Muhammad , Haikal Haikal , Nugroho Bayu Yoni Setyo , Rizqulloh Lutfiyah , Puspitasari Adelia
Published: January 2023

Puskesmas menjadi ujung tombak dalam upaya mengurangi mobilitas penyebaran Covid-19. Permasalahan yang sering terjadi pada pelayanan rawat jalan di Puskesmas terkait dengan waktu tunggu yang lama untuk mendapatkan pelayanan kesehatan yang dibutuhkan. Dinas Kesehatan Kota Semarang memanfaatkan teknologi informasi dengan membuat PUSTAKA (Puskesmas Tanpa Tanya Di Kota Semarang). Tujuan penelitian ini adalah untuk mendeskripsikan sebaran penerimaan pengunjung Puskesmas Terakreditasi Paripurna (Gayamsari dan Halmahera) dalam pemanfaatan PUSTAKA di kota Semarang. Penelitian ini menggunakan desain penelitian cross sectional dengan menggunakan pendekatan model Unified Theory of Acceptance and Use of Technology 2 (UTAUT 2). Penelitian dilaksanakan pada bulan Desember 2021 sampai Januari 2022 di Puskesmas Gayamsari dan Puskesmas Halmahera Kota Semarang. Sampel penelitian sebanyak 125 responden. Pengolahan data menggunakan Analisis Univariat. Berdasarkan hasil penelitian didapatkan bahwa pasien memiliki harapan kinerja tinggi sebanyak 70 responden (56%), harapan usaha rendah sebanyak 63 responden (50,4%), pengaruh sosial rendah sebanyak 66 responden ( 52,8%, kondisi fasilitasi tinggi sebanyak 64 responden (51,2%), motivasi hedonis tinggi sebanyak 70 responden (56%), dan kebiasaan tinggi sebanyak 72 responden (57,6%).
KAJIAN PENGENDALIAN PERSEDIAAN OBAT DI INSTALASI FARMASI DINAS KESEHATAN KABUPATEN “X” JAWA TENGAH
Authors: Munisih Siti , Setiawati H Maria Caecilia N. , WS FX Sulistiyanto
Published: January 2023

ABC critical index analysis is a combination of ABC analysis which includes ABC analysis of value in use and ABC analysis of investment value. The ABC analysis method is a method of making classifications based on the set of values from the highest to the lowest value and is divided into 3 major groups called group A (high investment value), B (medium investment value), and C (low investment value).The purpose of this study was to determine the compatibility, and realization and provide an evaluation of the planning for the use of drugs using the ABC method in the pharmaceutical installation health department of  “X” district, Central Java. The sampling technique used in this research is purposive sampling where the sample is taken according to the sample criteria.Data on Usage Reports and Drug Request Sheets for all UPTD Public Health Centers of  “X” Regency from January - December 2019 and January - December 2020. In the use of drugs in 2019 there were 343 types of drugs, consisting of group A as many as 64 drug items (18.66%) with a procurement cost of Rp. 3,647,892,228.00,- (74.83%), group B as many as 98 drug items (28.57%) with a cost of Rp. 980.902.019.40,- (20.12%). While those included in group C were 181 items (52.77%) with a cost of Rp. 246.216,758.60,- (5.29%). The results show that the budget needed for drug procurement in 2019 is IDR 4,875,011,006,00, - in 2020 there are 487 types of drugs, group A consists of 50 drug items (10.27%) with procurement costs of IDR 5,167,276,066 ,00,- (74.38%). A total of 104 drug items were included in group B (21.36%) with a cost of Rp. 1,392,954,441.00 (34.1%). While those included in group C were 333 items (68.38%) with a cost of Rp. 387,321,439.00, - (8.41%). The results show that the budget needed for drug procurement in 2020 is IDR 6,974,551,946,00,-. Keywords: compatibility, realization, evaluation, ABC
ANALISIS FAKTOR RISIKO KONDISI LINGKUNGAN LUAR RUMAH DENGAN KASUS MALARIA PADA MASYARAKAT DI INDONESIA - META ANALYSIS 2016-2021
Authors: Fadillah Ganish Eka , Azizah R.
Published: January 2023

Malaria is an infectious disease caused by the Plasmodium which is transmitted to humans through the bite of an Anopheles sp mosquito (WHO, 2020). This study aims to analyze the risk factors for environmental conditions outside the home with malaria cases in the community in Indonesia by systematically tracing research from national publications. This type of research is a systematic review and meta-analysis using JASP software version 0.9.2. The data source used is secondary data for the last 5 years (2016-2021) obtained through the Google Scholar, Science Direct, Pubmed according to the inclusion and exclusion criteria. Obtained 24 research articles relevant to the case control design. Based on the results of the meta-analysis, it was found that the presence of breeding places with an OR of 4.263 (95% CI 2.80 – 6.42), the presence of bushes with an OR of 5.989 (95% CI 1.92 – 18.54), and the presence of cattle pens with OR 2.858 (95% CI 1.04 – 7.85). The conclusion of this study is that the highest risk factor in this study is the variable presence of bushes which has a 5,989 times greater risk of malaria cases in people in Indonesia.
Gallium-modified gelatin nanoparticles loaded with quercetin promote skin wound healing via the regulation of bacterial proliferation and macrophage polarization
Authors: Yang Ning , Shi Nianyuan , Yao Zhou , Liu Hang , Guo Weinan
Published: January 2023

Background: Wound healing is a complicated process involving multiple cell components and can help the re-establishment of the skin’s barrier function. Previous studies have pointed out that bacterial infection and sustained inflammatory reactions are the main causes of the delay of wound closure and scar formation during wound healing. The effect of current approaches for scar-free wound repair still faces many challenges, and alternative therapeutic methods are urgently needed to be established.

Methods: The basic characteristics of the new-designed nanoparticles were clarified through the characterization of the material. The biocompatibility of the nanoparticles, as well as its effect on fibroblast function, anti-bacterial capacity, inflammation suppressive role, and the underlying mechanism were further verified by a panel of biochemical assays in vitro. Ultimately, pre-clinical rat model was employed to testify its role in wound healing and scar formation in vivo.

Results: Firstly, gallium-modified gelatin nanoparticles loaded with quercetin was successfully established, displaying good biocompatibility and facilitative effect on fibroblast function. In addition, the nanoparticles showed prominent anti-bacterial and inflammation-suppressive effects. What’s more important, the nanoparticles could also induce the polarization of macrophages from M1 to M2 phenotype to exert its inflammatory inhibitory role through TGF-β/Smad signaling pathway. Ultimately, in vivo experiment showed that the nanoparticles could effectively promote wound repair and inhibit scar formation during the process of wound healing.

Conclusion: Taken together, the new nanoparticles have good anti-bacterial and anti-scar formation effects and great potential in the field of skin wound repair, which provides a promising therapeutic strategy for wound treatment.
Shape-memory responses compared between random and aligned electrospun fibrous mats
Authors: Wang Xianliu , Zhang Zhaowenbin , Qin Chunping , Guo Xuran , Zhang Yanzhong
Published: January 2023

Significant progress has been made in the design of smart fibers toward achieving improved efficacy in tissue regeneration. While electrospun fibers can be engineered with shape memory capability, both the fiber structure and applied shape-programming parameters are the determinants of final performance in applications. Herein, we report a comparison study on the shape memory responses compared between electrospun random and aligned fibers by varying the programming temperature Tprog and the deforming strain εdeform. A PLLA–PHBV (6:4 mass ratio) polymer blend was first electrospun into random and aligned fibrous mat forms; thereafter, the effects of applying specific Tprog (37°C and 46°C) and εdeform (30%, 50%, and 100%) on the morphological change, shape recovery efficiency, and switching temperature Tsw of the two types of fibrous structures were examined under stress-free condition, while the maximum recovery stress σmax was determined under constrained recovery condition. It was identified that the applied Tprog had less impact on fiber morphology, but increasing εdeform gave rise to attenuation in fiber diameters and bettering in fiber orientation, especially for random fibers. The efficiency of shape recovery was found to correlate with both the applied Tprog and εdeform, with the aligned fibers exhibiting relatively higher recovery ability than the random counterpart. Moreover, Tsw was found to be close to Tprog, thereby revealing a temperature memory effect in the PLLA–PHBV fibers, with the aligned fibers showing more proximity, while the σmax generated was εdeform-dependent and 2.1–3.4 folds stronger for the aligned one in comparison with the random counterpart. Overall, the aligned fibers generally demonstrated better shape memory properties, which can be attributed to the macroscopic structural orderliness and increased molecular orientation and crystallinity imparted during the shape-programming process. Finally, the feasibility of using the shape memory effect to enable a mechanoactive fibrous substrate for regulating osteogenic differentiation of stem cells was demonstrated with the use of aligned fibers.
Stiffening effects-controlling sizing procedure of ADAS dampers in seismic retrofit of frame structures
Authors: Terenzi Gloria , Sorace Stefano , Fuso Elena
Published: January 2023

Added Damping and Stiffness (ADAS) steel dissipators are among the most classical devices installed in dissipative bracing systems for the advanced seismic retrofit of frame buildings. An energy-based sizing procedure is formulated in this study for this class of dampers, where the total number of constituting plates is directly related, without iterative steps, to the supplementary damping energy required to jointly reduce stress states in structural members and storey drifts. The stiffening effects of the dissipative braces are expressly controlled, so as to compensate for the increase in storey shears induced by their incorporation in the frame skeleton. The sizing procedure is demonstratively applied to the retrofit design of a 6-storey reinforced concrete building, to explicate and discuss the use of its analytical relations and relevant limitations in practice. The evaluation of the seismic performance of the structure in retrofitted conditions allows comparing the response of the dissipative bracing system with the hypotheses formulated at the sizing stage.
The relationship between national cultural dimensions, maternal anxiety and depression, and national breastfeeding rates: An analysis of data from 122 countries
Authors: Rajkumar Ravi Philip
Published: January 2023

Introduction

Breastfeeding is a natural and universal practice across countries and cultures. It is estimated that several thousand lives could be saved per year if optimal breastfeeding practices were adopted across countries. In addition, breastfeeding has numerous health, emotional and developmental benefits for both the mother and her infant. Despite widespread awareness of these benefits, rates of breastfeeding initiation and maintenance remain suboptimal, both in high- and in low- and middle-income countries. Unfavorable breastfeeding outcomes are related to several factors, including variations in cultural values and the occurrence of common mental disorders in women during pregnancy and in the postnatal period. However, the relative contributions of culture and mental health to variations in national breastfeeding rates have not been examined to date.

Methods

In the current study, recent United Nations International Children's Emergency Fund (UNICEF) data on lifetime breastfeeding rates is analyzed in two stages, to first explore and then confirm the impact of cultural values and maternal mental health status at a cross-national level.

Results

It was found that the estimated prevalence of both depression and anxiety disorders in women of childbearing age was negatively correlated with breastfeeding rates. Significant associations were also observed for the cultural dimensions of individualism-collectivism and masculinity-femininity. The association between anxiety disorders and breastfeeding outcomes remained significant in multivariate analysis incorporating demographic and health variables that could exert a confounding effect.

Discussion

These results suggest that both cultural values and the assessment and treatment of maternal mental illness should be components of any programme aimed at communicating the benefits of breastfeeding or at improving breastfeeding outcomes. The inclusion of these components could help promote the values of cultural sensitivity, inclusiveness and equity in breastfeeding from a global perspective.
Plasma homocysteine levels and risk of congestive heart failure or cardiomyopathy: A Mendelian randomization study
Authors: Wang Xinyi , Chen Zhuo , Tian Wende , Zhang Jie , Li Qiuyi , Ju Jianqing , Xu Hao , Chen Keji
Published: January 2023

Background

Although observational studies have demonstrated associations between elevated plasma homocysteine levels and the risk of cardiovascular diseases, controversy remains.

Objective

This study investigated the causal association of plasma homocysteine levels with congestive heart failure and cardiomyopathy risk.

Methods

We performed a two-sample Mendelian randomization (MR) study of congestive heart failure (n = 218,792), cardiomyopathy (n = 159,811), and non-ischemic cardiomyopathy (n = 187,152). Genetic summary data on the association of single-nucleotide polymorphisms with homocysteine were extracted from the most extensive genome-wide association study of 44,147 individuals. MR analyses, including the random-effect inverse variance-weighted (IVW) meta-analysis, weighted median, simple median, maximum likelihood, penalized weighted median, MR-PRESSO, and MR-Egger regression, were used to estimate the associations between the selected single-nucleotide polymorphisms and congestive heart failure or cardiomyopathy.

Results

The MR analyses revealed no causal role of higher genetically predicted plasma homocysteine levels with congestive heart failure risk (random-effect IVW, odds ratio [OR] per standard deviation (SD) increase in homocysteine levels = 1.753, 95% confidence interval [CI] = 0.674–4.562, P = 0.250), cardiomyopathy (random-effect IVW, OR per SD increase in homocysteine levels = 0.805, 95% CI = 0.583 to 1.020, P = 0.189), or non-ischemic cardiomyopathy (random-effect IVW, OR per SD increase in homocysteine levels = 1.064, 95% CI = 0.927–1.222, P = 0.379). The results were consistent with other analytical methods and sensitivity analyses.

Conclusion

Genetically predicted homocysteine level was not associated with congestive heart failure or cardiomyopathy risk. It is unlikely that homocysteine-lowering therapy decreases the incidence or improves the outcomes of congestive heart failure and cardiomyopathy.