bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei
Authors: Emmi Aron , Rizzo Stefania , Barzon Luisa , Sandre Michele , Carturan Elisa , Sinigaglia Alessandro , Riccetti Silvia , Della Barbera Mila , Boscolo-Berto Rafael , Cocco Patrizia , Macchi Veronica , Antonini Angelo , De Gaspari Monica , Basso Cristina , De Caro Raffaele , Porzionato Andrea
Published: February 2023

Neurological manifestations are common in COVID-19, the disease caused by SARS-CoV-2. Despite reports of SARS-CoV-2 detection in the brain and cerebrospinal fluid of COVID-19 patients, it is still unclear whether the virus can infect the central nervous system, and which neuropathological alterations can be ascribed to viral tropism, rather than immune-mediated mechanisms. Here, we assess neuropathological alterations in 24 COVID-19 patients and 18 matched controls who died due to pneumonia/respiratory failure. Aside from a wide spectrum of neuropathological alterations, SARS-CoV-2-immunoreactive neurons were detected in the dorsal medulla and in the substantia nigra of five COVID-19 subjects. Viral RNA was also detected by real-time RT-PCR. Quantification of reactive microglia revealed an anatomically segregated pattern of inflammation within affected brainstem regions, and was higher when compared to controls. While the results of this study support the neuroinvasive potential of SARS-CoV-2 and characterize the role of brainstem inflammation in COVID-19, its potential implications for neurodegeneration, especially in Parkinson’s disease, require further investigations.
Differential requirement of neutralizing antibodies and T cells on protective immunity to SARS-CoV-2 variants of concern
Authors: Azevedo Patrick O. , Hojo-Souza Natália S. , Faustino Lídia P. , Fumagalli Marcílio J. , Hirako Isabella C. , Oliveira Emiliano R. , Figueiredo Maria M. , Carvalho Alex F. , Doro Daniel , Benevides Luciana , Durigon Edison , Fonseca Flávio , Machado Alexandre M. , Fernandes Ana P. , Teixeira Santuza R. , Silva João S. , Gazzinelli Ricardo T.
Published: February 2023

The current COVID-19 vaccines protect against severe disease, but are not effective in controlling replication of the Variants of Concern (VOCs). Here, we used the existing pre-clinical models of severe and moderate COVID-19 to evaluate the efficacy of a Spike-based DNA vaccine (pCTV-WS) for protection against different VOCs. Immunization of transgenic (K18-hACE2) mice and hamsters induced significant levels of neutralizing antibodies (nAbs) to Wuhan and Delta isolates, but not to the Gamma and Omicron variants. Nevertheless, the pCTV-WS vaccine offered significant protection to all VOCs. Consistently, protection against lung pathology and viral load to Wuhan or Delta was mediated by nAbs, whereas in the absence of nAbs, T cells controlled viral replication, disease and lethality in mice infected with either the Gamma or Omicron variants. Hence, considering the conserved nature of CD4 and CD8 T cell epitopes, we corroborate the hypothesis that induction of effector T-cells should be a main goal for new vaccines against the emergent SARS-CoV-2 VOCs.
Asbestos exposure as an additional risk factor for small duct intrahepatic cholangiocarcinoma: a pilot study
Authors: Vasuri Francesco , Deserti Marzia , Corradini Angelo G. , Tavolari Simona , Relli Valeria , Palloni Andrea , Frega Giorgio , Curti Stefania , Mattioli Stefano , Cescon Matteo , D’Errico Antonia , Brandi Giovanni
Published: February 2023

Intrahepatic cholangiocarcinoma (iCCA) is a rare malignancy, recently classified in small duct and large duct morphological subtypes. Growing evidence suggests asbestos as a putative risk factor for iCCA, albeit no correlation between asbestos and iCCA morphology has been investigated so far. The aim of the present study was to assess the relationship between asbestos exposure and iCCA morphological subtype. Forty patients with surgically removed iCCA were prospectively enrolled: asbestos exposure was assessed according to the Italian National Mesothelioma Register questionnaire. From the surgical iCCA specimens the main histopathological variables were collected, including the small duct (sd-iCCA, 32 patients) and large duct subtypes (ld-iCCA, 8 patients). Five sd-iCCA cases had a definite/probable occupational exposure to asbestos, while no cases of ld-iCCA were classified as being occupationally exposed (definite/probable). Other kind of asbestos exposure (i.e. possible occupational, familial, environmental) were recorded in 16 sd-iCCA and 3 ld-iCCA. Cases with unlikely exposure to asbestos were 11 sd-iCCA (35.5%) and 5 ld-iCCA (62.5%). In conclusion, these findings seem to indicate that sd-iCCA might be more frequently associated to asbestos exposure rather than ld-iCCA, suggesting that asbestos fibres might represent a parenchymal, rather than a ductal risk factor for iCCA. This pilot study must be confirmed by further case–control studies or large independent cohorts.
An extensive study on multiple ETL and HTL layers to design and simulation of high-performance lead-free CsSnCl3-based perovskite solar cells
Authors: Hossain M. Khalid , Toki G. F. Ishraque , Kuddus Abdul , Rubel M. H. K. , Hossain M. M. , Bencherif H. , Rahman Md. Ferdous , Islam Md. Rasidul , Mushtaq Muhammad
Published: February 2023

Cesium tin chloride (CsSnCl3) is a potential and competitive absorber material for lead-free perovskite solar cells (PSCs). The full potential of CsSnCl3 not yet been realized owing to the possible challenges of defect-free device fabrication, non-optimized alignment of the electron transport layer (ETL), hole transport layer (HTL), and the favorable device configuration. In this work, we proposed several CsSnCl3-based solar cell (SC) configurations using one dimensional solar cell capacitance simulator (SCAPS-1D) with different competent ETLs like indium–gallium–zinc–oxide (IGZO), tin-dioxide (SnO2), tungsten disulfide (WS2), ceric dioxide (CeO2), titanium dioxide (TiO2), zinc oxide (ZnO), C60, PCBM, and HTLs of cuprous oxide (Cu2O), cupric oxide (CuO), nickel oxide (NiO), vanadium oxide (V2O5), copper iodide (CuI), CuSCN, CuSbS2, Spiro MeOTAD, CBTS, CFTS, P3HT, PEDOT:PSS. Simulation results revealed that ZnO, TiO2, IGZO, WS2, PCBM, and C60 ETLs-based halide perovskites with ITO/ETLs/CsSnCl3/CBTS/Au heterostructure exhibited outstanding photoconversion efficiency retaining nearest photovoltaic parameters values among 96 different configurations. Further, for the six best-performing configurations, the effect of the CsSnCl3 absorber and ETL thickness, series and shunt resistance, working temperature, impact of capacitance, Mott–Schottky, generation and recombination rate, current–voltage properties, and quantum efficiency on performance were assessed. We found that ETLs like TiO2, ZnO, and IGZO, with CBTS HTL can act as outstanding materials for the fabrication of CsSnCl3-based high efficiency (η ≥ 22%) heterojunction SCs with ITO/ETL/CsSnCl3/CBTS/Au structure. The simulation results obtained by the SCAPS-1D for the best six CsSnCl3-perovskites SC configurations were compared by the wxAMPS (widget provided analysis of microelectronic and photonic structures) tool for further validation. Furthermore, the structural, optical and electronic properties along with electron charge density, and Fermi surface of the CsSnCl3 perovskite absorber layer were computed and analyzed using first-principle calculations based on density functional theory. Thus, this in-depth simulation paves a constructive research avenue to fabricate cost-effective, high-efficiency, and lead-free CsSnCl3 perovskite-based high-performance SCs for a lead-free green and pollution-free environment.
Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties
Authors: Noori Milad , Sabourian Reyhaneh , Tasharoie Ali , Safavi Maliheh , Iraji Aida , Khalili Ghomi Minoo , Dastyafteh Navid , Irajie Cambyz , Zarenezhad Elham , Mostafavi Pour Seyyed Mehrdad , Rasekh Fatemeh , Larijani Bagher , Amini Mohsen , Hajimahmoodi Mannan , Mahdavi Mohammad
Published: February 2023

In the present study, a series of aryl-substituted thioqunoline conjugated to thiosemicarbazide were rationally designed and synthesized. The formation of target compounds was confirmed by spectral characterization techniques such as IR, 1H-NMR, 13C-NMR, ESI–MS, and elemental analysis. Among the synthesized derivatives, compound 10g bearing para-chlorophenyl moiety was proved to be the most potent tyrosinase inhibitor with an IC50 value of 25.75 ± 0.19 µM. Compound 10g as the most potent derivative exhibited a noncompetitive inhibition pattern against tyrosinase in the kinetic study. Furthermore, the in silico cavity detection, as well as the molecular docking assessments, were performed to follow the behavior of 10g within the proposed binding site. Besides, the toxicity of 10g and its potency to reduce the melanin content on A375 cell lines were also measured. Consequently, aryl-substituted thioqunolines conjugated to thiosemicarbazide might be a promising candidate in the cosmetics, medicine, and food industry as tyrosinase inhibitors.
Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography
Authors: Choi Sang Uk , Kim Yoon Jeon , Lee Joo Yong , Lee Junyeop , Yoon Young Hee
Published: February 2023

To investigate angiographic characteristic features of diabetic choroidopathy, as well as choroidal vascular density (CVD) and fractal dimension (CFD) in diabetic eyes and controls using ultra-widefield (UWF) indocyanine green angiography (ICGA). All patients underwent UWF fluorescein angiography and ICGA. Using imageJ software, CVD and CFD was analyzed. SFCT was assessed using spectral-domain optical coherence tomography. The image parameters were compared based on the DR stage and the presence of diabetic macular edema (DME). One-hundred six eyes from 63 patients (59.11 ± 16.31 years; male [%]: 23 [36.5%]) were included in the DM group, and 40 eyes from 22 subjects were included in the control group. The DM group had a mean age of 59.11 ± 16.31 years and a mean HbA1c percentage of 7.72 ± 1.28%. The most common ICGA findings of DC were choroidal hyperpermeability (57.5%), hypofluorescent spots (48.1%). Salt and pepper pattern (19.8%), inverted inflow phenomenon (3.8%), choroidal arterial tortuosity (24.5%), and late choroidal non-perfusion (6.6%) were more common in advanced DR. The CVD, CFD, and SFCT increased as the DR severity progressed. The DME group had a significantly higher CFD and SFCT than the non-DME group (P < 0.001 and P = 0.019, respectively). The qualitative and quantitative UWF ICGA image analysis revealed that choroidal blood vessels became dilated, complex, and hyperpermeable as the DR progressed. These features of diabetic choroidopathy (DC) were more severe in eyes with DME than the non-DME eyes.
Optimization of the hydrogen response characteristics of halogen-doped SnO2
Authors: Filippatos Petros-Panagis , Sharma Rohit , Soultati Anastasia , Kelaidis Nikolaos , Petaroudis Christos , Alivisatou Anastasia-Antonia , Drivas Charalampos , Kennou Stella , Christopoulos Stavros-Richard G. , Davazoglou Dimitris , Vasilopoulou Maria , Chroneos Alexander
Published: February 2023

The increasing demand for efficient sensing devices with facile low-cost fabrication has attracted a lot of scientific research effort in the recent years. In particular, the scientific community aims to develop new candidate materials suitable for energy-related devices, such as sensors and photovoltaics or clean energy applications such as hydrogen production. One of the most prominent methods to improve materials functionality and performance is doping key device component(s). This paper aims to examine in detail, both from a theoretical and an experimental point of view, the effect of halogen doping on the properties of tin dioxide (SnO2) and provide a deeper understanding on the atomic scale mechanisms with respect to their potential applications in sensors. Density Functional Theory (DFT) calculations are used to examine the defect processes, the electronic structure and the thermodynamical properties of halogen-doped SnO2. Calculations show that halogen doping reduces the oxide bandgap by creating gap states which agree well with our experimental data. The crystallinity and morphology of the samples is also altered. The synergy of these effects results in a significant improvement of the gas-sensing response. This work demonstrates for the first time a complete theoretical and experimental characterization of halogen-doped SnO2 and investigates the possible responsible mechanisms. Our results illustrate that halogen doping is a low-cost method that significantly enhances the room temperature response of SnO2.
Fabrication of untreated and silane-treated carboxylated cellulose nanocrystals and their reinforcement in natural rubber biocomposites
Authors: Lorwanishpaisarn Narubeth , Sae-Oui Pongdhorn , Amnuaypanich Sittipong , Siriwong Chomsri
Published: February 2023

In this study, cellulose nanocrystal (CNC) was extracted from Napier grass stems and subsequently functionalized to carboxylated cellulose nanocrystal (XCNC) by using an environmentally friendly method, namely, the KMnO4/oxalic acid redox reaction. The XCNC was subsequently modified with triethoxyvinylsilane (TEVS), called VCNC, by using ultrasound irradiation. The characterization of the prepared XCNC and VCNC was performed. The needle-like shape of XCNC was observed with an average diameter and length of 11.5 and 156 nm, respectively. XCNC had a carboxyl content of about 1.21 mmol g−1. The silane treatment showed no significant effects on the diameter and length of XCNC. When incorporated into natural rubber (NR), both XCNC and VCNC showed very high reinforcement, as evidenced by the substantial increases in modulus and hardness of the biocomposites, even at very low filler loadings. However, due to the high polarity of XCNC, tensile strength was not significantly improved with increasing XCNC loading up to 2 phr, above which it decreased rapidly due to the filler agglomeration. For VCNC, the silane treatment reduced hydrophilicity and improved compatibility with NR. The highly reactive vinyl group on the VCNC’s surface also takes part in sulfur vulcanization, leading to the strong covalent linkages between rubber and VCNC. Consequently, VCNC showed better reinforcement than XCNC, as evidenced by the markedly higher tensile strength and modulus, when compared at an equal filler loading. This study demonstrates the achievement in the preparation of a highly reinforcing bio-filler (VCNC) for NR from Napier grass using an environmentally friendly method and followed by a quick and simple sonochemical method.
ATR-FTIR spectroscopy of plasma supported by multivariate analysis discriminates multiple sclerosis disease
Authors: Crocco Maria Caterina , Moyano María Fernanda Heredia , Annesi Ferdinanda , Bruno Rosalinda , Pirritano Domenico , Del Giudice Francesco , Petrone Alfredo , Condino Francesca , Guzzi Rita
Published: February 2023

Multiple sclerosis (MS) is one of the most common neurodegenerative diseases showing various symptoms both of physical and cognitive type. In this work, we used attenuated total reflection Fourier transformed infrared (ATR-FTIR) spectroscopy to analyze plasma samples for discriminating MS patients from healthy control individuals, and identifying potential spectral biomarkers helping the diagnosis through a quick non-invasive blood test. The cohort of the study consists of 85 subjects, including 45 MS patients and 40 healthy controls. The differences in the spectral features both in the fingerprint region (1800–900 cm−1) and in the high region (3050–2800 cm−1) of the infrared spectra were highlighted also with the support of different chemometric methods, to capture the most significant wavenumbers for the differentiation. The results show an increase in the lipid/protein ratio in MS patients, indicating changes in the level (metabolism) of these molecular components in the plasma. Moreover, the multivariate tools provided a promising rate of success in the diagnosis, with 78% sensitivity and 83% specificity obtained through the random forest model in the fingerprint region. The MS diagnostic tools based on biomarkers identification on blood (and blood component, like plasma or serum) are very challenging and the specificity and sensitivity values obtained in this work are very encouraging. Overall, the results obtained suggest that ATR-FTIR spectroscopy on plasma samples, requiring minimal or no manipulation, coupled with statistical multivariate approaches, is a promising analytical tool to support MS diagnosis through the identification of spectral biomarkers.
Performance of classification and diagnostic criteria for IgG4-related disease and comparison of patients with and without IgG4-related disease
Authors: Kogami Masahiro , Abe Yoshiyuki , Ando Taiki , Makiyama Ayako , Yamaji Ken , Tamura Naoto
Published: February 2023

IgG4-related disease (IgG4-RD) was recently described in Japan. It is characterised by extensive organ involvement with tissue fibrosis. We assessed the performance of the 2019 American College of Rheumatology and European League Against Rheumatism (ACR/EULAR) classification criteria and the 2020 revised comprehensive diagnostic (RCD) criteria as well as differences between patients with and without IgG4-RD. In this retrospective, single-centre study of 50 patients admitted with suspected IgG4-RD, we evaluated the sensitivity and specificity of both criteria. We also compared clinical characteristics and laboratory data of patients with IgG4-RD (n = 42) and patients without IgG4-RD (n = 8). The ACR/EULAR classification criteria had 88.1% sensitivity and 87.5% specificity for IgG4-RD diagnosis. The RCD criteria had 100% sensitivity and 50% specificity. Patients with IgG4-RD had significantly more affected organs (p = 0.002). Patients with a single affected organ and IgG4-RD had significantly higher serum IgG4/IgG ratios (p = 0.027), lower serum C-reactive protein levels (p = 0.020), and lower total haemolytic complement activity (p = 0.044) than those without IgG4-RD. The ACR/EULAR classification criteria have high specificity and the RCD criteria have high sensitivity for diagnosing IgG4-RD. The number of affected organs is important for diagnosing IgG4-RD.
Echo state graph neural networks with analogue random resistive memory arrays
Authors: Wang Shaocong , Li Yi , Wang Dingchen , Zhang Woyu , Chen Xi , Dong Danian , Wang Songqi , Zhang Xumeng , Lin Peng , Gallicchio Claudio , Xu Xiaoxin , Liu Qi , Cheng Kwang-Ting , Wang Zhongrui , Shang Dashan , Liu Ming
Published: February 2023

Recent years have witnessed a surge of interest in learning representations of graph-structured data, with applications from social networks to drug discovery. However, graph neural networks, the machine learning models for handling graph-structured data, face significant challenges when running on conventional digital hardware, including the slowdown of Moore’s law due to transistor scaling limits and the von Neumann bottleneck incurred by physically separated memory and processing units, as well as a high training cost. Here we present a hardware–software co-design to address these challenges, by designing an echo state graph neural network based on random resistive memory arrays, which are built from low-cost, nanoscale and stackable resistors for efficient in-memory computing. This approach leverages the intrinsic stochasticity of dielectric breakdown in resistive switching to implement random projections in hardware for an echo state network that effectively minimizes the training complexity thanks to its fixed and random weights. The system demonstrates state-of-the-art performance on both graph classification using the MUTAG and COLLAB datasets and node classification using the CORA dataset, achieving 2.16×, 35.42× and 40.37× improvements in energy efficiency for a projected random resistive memory-based hybrid analogue–digital system over a state-of-the-art graphics processing unit and 99.35%, 99.99% and 91.40% reductions of backward pass complexity compared with conventional graph learning. The results point to a promising direction for next-generation artificial intelligence systems for graph learning.
KDM8 epigenetically controls cardiac metabolism to prevent initiation of dilated cardiomyopathy
Authors: Ahmed Abdalla , Syed Jibran Nehal , Chi Lijun , Wang Yaxu , Perez-Romero Carmina , Lee Dorothy , Kocaqi Etri , Caballero Amalia , Yang Jielin , Escalante-Covarrubias Quetzalcoatl , Ishimura Akihiko , Suzuki Takeshi , Aguilar-Arnal Lorena , Gonzales Gerard Bryan , Kim Kyoung-Han , Delgado-Olguín Paul
Published: February 2023

Cardiac metabolism is deranged in heart failure, but underlying mechanisms remain unclear. Here, we show that lysine demethylase 8 (Kdm8) maintains an active mitochondrial gene network by repressing Tbx15, thus preventing dilated cardiomyopathy leading to lethal heart failure. Deletion of Kdm8 in mouse cardiomyocytes increased H3K36me2 with activation of Tbx15 and repression of target genes in the NAD+ pathway before dilated cardiomyopathy initiated. NAD+ supplementation prevented dilated cardiomyopathy in Kdm8 mutant mice, and TBX15 overexpression blunted NAD+-activated cardiomyocyte respiration. Furthermore, KDM8 was downregulated in human hearts affected by dilated cardiomyopathy, and higher TBX15 expression defines a subgroup of affected hearts with the strongest downregulation of genes encoding mitochondrial proteins. Thus, KDM8 represses TBX15 to maintain cardiac metabolism. Our results suggest that epigenetic dysregulation of metabolic gene networks initiates myocardium deterioration toward heart failure and could underlie heterogeneity of dilated cardiomyopathy.
Superior biocompatible carbon dots for dynamic fluorescence imaging of nucleoli in living cells
Authors: Lin Liyun , Bao Zhouzhou , Jiang Pengfei , Xu Zhourui , Shi Bo , Xu Gaixia , Wang Dan , Wei Xunbin , Gu Bobo
Published: February 2023

A carbon dots with intrinsic nucleolus-targeting capability and superior biocompatibility was synthesized and employed for dynamic fluorescence imaging of nucleolus in living cells.
Transferrin receptor 1 targeted nanomedicine for brain tumor therapy
Authors: Li Jianru , Zhang Zixia , Zhang Baoli , Yan Xiyun , Fan Kelong
Published: February 2023

This review summarizes the latest advances in TfR1-targeted nanomedicine for brain tumor therapy.
SREBP activation contributes to fatty acid accumulations in necroptosis
Authors: Lu Daniel , Parisi Laura R. , Gokcumen Omer , Atilla-Gokcumen G. Ekin
Published: February 2023

.Necroptosis is accompanied by accumulation of lipids. This study shows that SREBPs are activated and cause increase in the production of very long-chain fatty acids during necroptosis.
Stepwise assembly of heterometallic, heteroleptic “triblock Janus-type” metal–organic polyhedra
Authors: von Baeckmann Cornelia , Ruiz-Relaño Sara , Imaz Inhar , Handke Marcel , Juanhuix Judith , Gándara Felipe , Carné-Sanchez Arnau , Maspoch Daniel
Published: February 2023

We present a novel strategy to assemble diverse metal ions and organic linkers into metal–organic polyhedra (MOPs). It involves use of a pre-assembled complex of a parent MOP to replicate this cage with a multicomponent character.
Real-space resolved surface reactions: deprotonation and metalation of phthalocyanine
Authors: Christ Andreas , Bode Matthias , Leisegang Markus
Published: February 2023

Two competing surface-induced reactions of H2Pc adsorbed on Cu(111) were studied. The asymmetric rotational behaviour of H2Pc and CuPc was investigated.
Predicting pharmaceutical powder flow from microscopy images using deep learning
Authors: Wilkinson Matthew R. , Pereira Diaz Laura , Vassileiou Antony D. , Armstrong John A. , Brown Cameron J. , Castro-Dominguez Bernardo , Florence Alastair J.
Published: February 2023

We present deep learning to predict the flowability of pharmaceuticals from microscopy images. This enables flowability assessments with smaller API quantities, saving experiment time and costs when material is limited during early drug development.
Deciphering the photocatalytic hydrogen generation process of Fresnoite Ba2TiGe2O8 by electronic structure and bond analyses
Authors: Lu Guangxiang , Yang Tao
Published: February 2023

In Ba2TiGe2O8, the electrons in O 2p non-bonding orbitals are UV-excited to either Ti–O or Ge–O anti-bonding orbitals, and the latter can form an infinite two-dimensional network for the easy migration of electrons.
Slow magnetic relaxation of a S = 1/2 copper(ii)-substituted Keggin-type silicotungstate
Authors: Ishizaki Toshiharu , Ozeki Tomoji
Published: February 2023

This is the first report on slow magnetic relaxation in an S = 1/2 system based on a first-row transition metal ion with the polyoxometalate skeleton [(n-C4H9)4N]4H2[SiW11O39Cu] (1).
Beyond Karl Fischer titration: a monolithic quantum cascade sensor for monitoring residual water concentration in solvents
Authors: Pilat Florian , Schwarz Benedikt , Baumgartner Bettina , Ristanić Daniela , Detz Hermann , Andrews Aaron M. , Lendl Bernhard , Strasser Gottfried , Hinkov Borislav
Published: February 2023

A sensitive and selective monolithic mid-IR lab-on-a-chip for real-time analysis of water-residuals in solvents with comparable LOD to Karl–Fischer titration.
Near ultraviolet light excitable highly efficient blue-green multicolour warwickite phosphor, ScCaO(BO3):Ce3+, Tb3+
Authors: Iwaki Masato , Sato Haruto , Watanabe Mizuki , Uematsu Kazuyoshi , Sato Mineo , Toda Kenji
Published: February 2023

Ce3+, Tb3+co-doped multicolour emission phosphors show highly efficient green emission by energy transfer from Ce3+to Tb3+.
Green room temperature synthesis of silver–gold alloy nanoparticles
Authors: Traoré N. E. , Uttinger M. J. , Cardenas Lopez P. , Drobek D. , Gromotka L. , Schmidt J. , Walter J. , Apeleo Zubiri B. , Spiecker E. , Peukert W.
Published: February 2023

Silver–gold alloy nanoparticles of well-controlled composition and narrow particle size distributionviaa room temperature, reaction-controlled, green and scalable synthesis route.
Field tunable magnetic transitions of CsCo2(MoO4)2(OH): a triangular chain structure with a frustrated geometry
Authors: Sanjeewa Liurukara D. , Garlea V. Ovidiu , Fishman Randy S. , Foroughian Mahsa , Yin Li , Xing Jie , Parker David S. , Smith Pellizzeri Tiffany M. , Sefat Athena S. , Kolis Joseph W.
Published: February 2023

We present a comprehensive series of magnetic and neutron scattering measurements of the sawtooth chain compound, CsCo2(MoO4)2(OH). The magnetic properties of CsCo2(MoO4)2(OH) can be easily manipulated by applied magnetic fields.
All-alkynyl-protected coinage metal nanoclusters: from synthesis to electrocatalytic CO2reduction applications
Authors: Chen Leyi , Wang Lei , Shen Quanli , Liu Yonggang , Tang Zhenghua
Published: February 2023

Alkynyl-protected metal nanoclusters possess unique advantages, and the recent progress on the controllable synthesis and CO2electroreduction application is discussed, with some explicit examples to elaborate the structure-performance relationship.
Ag-doped Pd nano-dendritic for promoting the electrocatalytic oxidation of ethylene to ethylene glycol
Authors: Li Xinwei , You Xiaoyu , Yan Zhuang , Yang Caoyu , Zuo Lulu , Huang Xuewei , Chang Lin , Lu Siyu , Tang Zhiyong
Published: February 2023

We report an Ag doped Pd nano-dendritic catalyst, which achieves high selectivity of EG production from ethylene. Both experiment and theory reveal that the catalyst not only reduces the reaction barrier of coupling steps but also facilitates the desorption of EG.
In vitro anti-inflammatory, in silico molecular docking and molecular dynamics simulation of oleanane-type triterpenes from aerial parts of Mussaenda recurvata
Authors: Tri Mai Dinh , Phat Nguyen Tan , Minh Phan Nhat , Chi Mai Thanh , Hao Bui Xuan , Minh An Tran Nguyen , Alam Mahboob , Van Kieu Nguyen , Dang Van-Son , Mai Tran Thi Ngoc , Duong Thuc-Huy
Published: February 2023

Two new triterpenes recurvatanes A and B were isolated from Mussaenda recurvata using bioactive-guided investigation.
Mechanism of tetraborate and silicate ions on the growth kinetics of microarc oxidation coating on a Ti6Al4V alloy
Authors: Zhai Dajun , Qiu Tao , Shen Jun , Feng Keqin
Published: February 2023

B4O72− dissolves molten TiO2 at high temperature, exposing filamentary channels and resulting in the repeated nucleation of microarc in the same area. SiO2 formed from SiO32− blocks the channels and induces microarc nucleation in other regions.
Is there a difference between surfactant-stabilised and Pickering emulsions?
Authors: Dekker Riande I. , Velandia Santiago F. , Kibbelaar Heleen V. M. , Morcy Azeza , Sadtler Véronique , Roques-Carmes Thibault , Groenewold Jan , Kegel Willem K. , Velikov Krassimir P. , Bonn Daniel
Published: February 2023

What measurable physical properties allow one to distinguish surfactant-stabilised from Pickering emulsions?
Unveiling the key intermediates in electrocatalytic synthesis of urea with CO2 and N2 coupling reactions on double transition-metal MXenes
Authors: Yang Yufei , Peng Jiahe , Shi Zuhao , Zhang Peng , Arramel Arramel , Li Neng
Published: February 2023

The mechanism of electrocatalytic synthesis of urea with CO2/N2 coupling reactions on double transition-metal MXenes.
Synergistic optimization of mechanical and photovoltaic properties in ternary organic solar cells from a two-donor polymer blend
Authors: Li Mingfei , Peng Zhongxiang , Xian Kaihu , Zhao Wenchao , Liu Chenxu , Chen Yu , Cui Chaohua , Ye Long
Published: February 2023

A low-cost and 2D semi-paracrystalline conjugated polymer PTQ10 yields higher efficiency and stretchability in dual donor ternary solar cells.
(Bi1/6Na1/6Ba1/6Sr1/6Ca1/6Pb1/6)TiO3-based high-entropy dielectric ceramics with ultrahigh recoverable energy density and high energy storage efficiency
Authors: Wang Hao , Zhang Ji , Jiang Shunshun , Wang Jiajia , Wang Jing , Wang Yaojin
Published: February 2023

The unique atom configuration in high-entropy dielectric ceramics gives rise to high Pmax, small Pr. Accordingly, ultrahigh recoverable energy density of 8.8 J cm−3 and high η of 92.5%, as well as excellent thermal stability, are achieved.
Supramolecular detoxification of nitrogen mustardviahost–guest encapsulation by carboxylatopillar[5]arene
Authors: Zhou Siyuan , Chen Yi , Xu Jie , Yin Yongfei , Yu Jianqing , Liu Wei , Chen Shigui , Wang Lu
Published: February 2023

Nitrogen mustard (NM), a kind of alkylating agent similar to sulfur mustard, remains a threat to public health.
A sensitive dual-signal electrochemiluminescence immunosensor based on Ru(bpy)32+@HKUST-1 and Ce2Sn2O7 for detecting the heart failure biomarker NT-proBNP
Authors: Ji Yu , He Shuang , Chen Yang , Zhang Pei , Sun Jing , Li Ya , Kuang Kaida , Jia Nengqin
Published: February 2023

A sensitive dual-signal ECL immunosensor based on Ru(bpy)32+@HKUST-1/TPA and emerging Ce2Sn2O7/K2S2O8 probes was proposed to detect the NT-proBNP biomarker of heart failure.
Ultrasensitive determination of α-glucosidase activity using CoOOH nanozymes and its application to inhibitor screening
Authors: Ma Demiao , Ge Jia , Wang Ang , Li Jingxian , Yang Hongfen , Zhai Wenlei , Cai Ren
Published: February 2023

A colorimetric method for facile sensing of α-glucosidase activity based on CoOOH nanoflakes exhibiting efficient oxidase-mimicking activity.
Ratiometric SERS detection of N2H4 by porous Ag(i)-linked Waugh-type polyoxometalate as an efficient label-free substrate
Authors: Wang Jie , Zhang Jia-Yuan , Zhu Wen-Jing , Qi Bin , Wang Jun-Peng , Gao Guang-Gang , Fan Lin-Lin , Liu Hong
Published: February 2023

A 3D silver(I)-polyoxometalate complex of Ag6[MnMo9O32]·4H2O was designed to realize the the elusive label-free SERS quantitative analysis for hydrazine, by which the ratiometric IMn-O/IMo-O signals are proportional to hydrazine concentrations.
Construction of gel networksvia[2+2] photocycloaddition
Authors: Zhao Lei-Min
Published: February 2023

Cross-linking of olefin moieties in branched polymers could furnish gel networksvia[2+2] photocycloadditions. And the obtained networks are reversible and self-healing, which show promising applications in biology and biomedical science.
Machine learning assisted binary alloy catalyst design for the electroreduction of CO2 to C2 products
Authors: Gariepy Zachary , Chen Guiyi , Xu Anni , Lu Zhuole , Chen Zhi Wen , Singh Chandra Veer
Published: February 2023

CO2RR binary alloy catalyst design insight gained through density functional theory and machine learning with a focus on COCOH adsorption energy.
Synthesis of π-extended and bowl-shaped sumanene–ferrocene conjugates and their application in highly selective and sensitive cesium cations electrochemical sensors
Authors: Cyniak Jakub S. , Kocobolska Łucja , Bojdecka Natalia , Gajda-Walczak Aleksandra , Kowalczyk Agata , Wagner Barbara , Nowicka Anna M. , Sakurai Hidehiro , Kasprzak Artur
Published: February 2023

New, structurally enhanced triferrocenylsumanenes were synthesized comprehensively characterized spectroscopically, and their supramolecular interactions with caesium cations were investigated spectroscopically and electrochemically.
Platinum(ii) diimine complexes containing phenylpyridine ligands decorated with anioniccloso-monocarborane clusters [CB11H12]−
Authors: Kong Xiangjun , Shen Yunjun , Bian Hedong , Zhang Yuzhen
Published: February 2023

We report three Pt(ii) diimine complexes containing ancillary ligands of phenylpyridine furnished with anioniccloso-monocarborane clusters [CB11H12]−.
Synthesis of a low-silica CHA zeolite with exceptional selectivity for radioactive137Cs+
Authors: Hao Wenfeng , Yan Xiaojun , Guo Xiliang , Wang Wentao , Yan Taihong , Zhang Jia-Nan , Yan Wenfu
Published: February 2023

A green and facile one-pot synthesis of a low-silica CHA zeolite with a Si/Al ratio of 2.06, which has exceptional selectivity and a deep removal ability for the capture of ppt-level radioactive137Cs+from real nuclear power wastewater.
Citric acid tuned negative thermal quenching of all inorganic copper-based perovskites
Authors: Yao Lu , Meng Hong , Liu Ming
Published: February 2023

Citric acid increase induces structure and better crystallinity and more surface defects of copper-based perovskite, resulting in higher luminescence and more surface energy states, which leads to enhanced thermal stability.
Correction: Single laser activated photothermal/photodynamic dual-modal cancer phototherapy by using ROS-responsive targeting flower-like ruthenium nanoparticles
Authors: Liu Yanan , Huang Junfang , Liu Jie
Published: February 2023

Correction for ‘Single laser activated photothermal/photodynamic dual-modal cancer phototherapy by using ROS-responsive targeting flower-like ruthenium nanoparticles’ by Yanan Liu et al., J. Mater. Chem. B, 2022, 10, 7760–7771, https://doi.org/10.1039/D2TB01276F.
Tuning charge carrier dynamics through spacer cation functionalization in layered halide perovskites: an ab initio quantum dynamics study
Authors: Nayak Pabitra Kumar , Ghosh Dibyajyoti
Published: February 2023

Fluorination of spacer cations compacts the layered halide perovskites, weakens the electron–phonon interactions, and suppresses the non-radiative charge carrier recombination processes.
Flybys in debris disk systems withGaiaeDR3
Authors: Bertini L. , Roccatagliata V. , Kim M.
Published: February 2023

Context.Debris disks represent the last phase of the evolution of protoplanetary disks around young stellar objects where planetary systems had most likely already been formed. Resolved systems show peculiar structures, such as asymmetries or spirals, which may be associated with either the presence of a low-mass companion or dynamical interactions with a perturber during a flyby event.

Aims.We aim to observationally and statistically constrain the influence of flybys in the formation and evolution of debris disks.

Methods.We compiled a sample of 254 debris disks with ages between 2 Myr and 8 Gyr that are either part of an association or isolated, drawing the binary and planetary companions of the systems mainly from the literature. Using theGaiaeDR3 astrometric data and radial velocities of our sample, as well as all the sources in a specific region of the sky, we reconstructed the relative linear motions in the last 5 Myr and made predictions for the next 2 Myr. Relating the Hill radius of each debris disk system and the closest distances reached by the two sources, we defined the flyby events in terms of position and time.

Results.We find that in the period between the last 5 Myrs and the next 2 Myrs, 90% of the analyzed systems have experienced at least a close flyby, while 7% of them have experienced flybys at distances greater than 0.5RHill. In particular, 75% of them have experienced at least one past close encounter and 36% multiple past close encounters. From the sub-sample of resolved debris disk (41 out of 94), 80% of the analyzed systems experience at least an encounter within 0.8 pc. From the subsample of 10 debris disks with planets, half of these systems do show misalignments between disk and planet, stirring, or asymmetries. Systems with a misalignment between the planetary orbit and the disk do indeed experience at least one flyby event. In particular, when the planet orbits have a difference with the disk inclination higher than about 20°, as in the case of HD 38529, we find that multiple close encounters have taken place in the last 5 Myr, as theoretically predicted.

Conclusions.The high incidence of encounters, particularly close encounters, experienced by the systems in the last 5 Myr suggests the fundamental impact of flybys on the evolution of debris disks. Moreover, despite the low statistics, it is interesting to highlight that flybys that have been theoretically predicted so far in peculiar resolved systems have also been observationally constrained.
New Teachers are Leaving the Profession: How can School Leadership Make a Difference?
Authors: Dai Jiaqi
Published: February 2023

The problem of loss of new qualified teachers has been a global issue which has a detrimental impact on the pool of future leadership positions and talented workforce in national labour markets. Despite the fact that a wide range of studies have investigated into the effects of mentoring and coaching on novice teacher retention, the leadership practices that highlight the development of teacher leadership capacities and resilience are currently insufficient. This article aims to examine the negative experiences of early career teachers (ECTs), who are in their first five years of teaching, and analyze how school leadership theories could support them by building positive working conditions. The development of ECTs’ sense of agency and resilience is emphasized in this paper through the utilization of two leadership theories: distributed leadership and caring leadership. It also clarifies recommendations for educational leaders and policymakers to enhance the quality of pre-service teacher education and induction programmes with the central premise that teacher professional development should be a career-long continuum.
Research on Training Strategies of Quantity Sense of Primary School Students under the Background of New Curriculum Criteria
Authors: Li Xufeng
Published: February 2023

Mathematics is a subject based on numbers and quantities. The quantity sense will affect students’ understanding of mathematics. The new curriculum criteria in 2022 have increased the discussion and requirements on the sense of quantity. The author analyses the significance of the sense of quantity, and investigates the situation of primary school students’ sense of quantity through questionnaires and interviews. The results show that the students’ overall mastery of the quantity sense is poor, especially in the estimation of volume unit. In view of the above problems, the article puts forward the strategies of cultivating the sense of quantity of primary school students under the background of the new curriculum standards, mainly including integrating quantity sense elements, enriching quantity sense accumulation and developing quantity sense reasoning to provide reference for relevant researchers.
Research and Practice of Mental Health Education for College Students in Local Colleges Research on Innovation of Teaching Model
Authors: Cheng Fang , Duan Xiaoming
Published: February 2023

Under the application-oriented talent training mode, theoretical and practical exploration is one of the effective parts of college students’ mental health education course. The three-dimensional practical teaching mode built by psychological evaluation, group psychological counseling and behavioral training in the course of “College Students’ Mental Health Education” is very obvious to the overall effect of the course teaching. This paper puts forward innovative strategies for practical teaching research and training of mental health education in local colleges and universities: strengthen the sense of identity of mental health teaching, combine reality with theory, extend after-class extension within class, so as to improve the teaching effect.
Analysis of the Psychological Impact of Tiktok on Contemporary Teenagers
Authors: Lin Zheng
Published: February 2023

With the development of information technology, short video has become an important part of people’s leisure life. Among them, Tiktok is the largest and fastest-growing application in the short video market, with about 1.5 billion users worldwide. Unlike other software, Tikotok’s users are mostly teenagers, but the contents on Tiktok are varied and even contain a lot of violence and pornography. So the psychological impact of this software on contemporary teenagers is huge. By analyzing high school students’ use of Tiktok data and the positive and negative effects of Tiktok on high school students’ psychology, this paper puts forward suggestions to help families, schools and governments take measures, and draw their attention to the mental health of contemporary adolescents and promote their physical and mental health, so as to promote the healthy growth of teenagers.
Principle and Application of Flexible Pressure Sensors
Authors: Zhang Ziyan
Published: February 2023

Flexible pressure sensors are widely used in many ways, including health care and machine sensors. Compared with the traditional flexible pressure sensor, flexible pressure sensor has quality is light, easy to carry and deformation degree higher advantages are modern science and technology advanced has broad prospects for the development of technology products. In recent years, Remarkable progress has been made in the field of flexible pressure sensors. However, it is still a big challenge to realize the high resolution, high sensitivity, fast response, low-cost manufacturing and complex signal detection of flexible pressure sensors. This paper will introduce the mechanism of the flexible pressure sensor and improve the sensitivity by using the microstructure and the practical application. The research in this paper will have a very important value for the research and application of the flexible pressure sensor.
The Influence Factors and Intervention of Children’s Gaming Addiction
Authors: Zhu Yuechen
Published: February 2023

With the gradual arrival of the information age, the network is playing a more and more important role in people’s life, permeating into every aspect of people life. The network game is a powerful source of attraction in the network and constantly contributes to the network flow. Game addiction has a negative impact on the psychological and physical levels of children and has become an increasingly prominent social problem. Therefore, this review is based on previous studies on children’s gaming addiction, including previous opinions and conclusions, and summarizes the influencing factors involved in children’s gaming addiction. This paper combines the previous research results on children’s game addiction in the field of applied psychology and summarizes the internal and external influencing factors of children’s game addiction. Among the internal factors, we found that whether children face the influence of game addiction is related to their impulsivity, self-control, and aggression. Among the external factors, it is not difficult to find that social class, academic pressure, and family environment all subtly affect the degree of addiction in children. Therefore, we found that the factors affecting children’s game addiction are multi-faceted and interrelated. In order to alleviate and prevent children’s game addiction to a certain extent, family intervention, stimulus intervention, social intervention, and medical intervention can be carried out. This paper is helpful to carry out further research on this basis, to carry out a more in-depth mechanism analysis at the level of applied psychology.
A Review of Higher Education Students’ Online Engagement Under The COVID-19 Pandemic
Authors: Xue Yuxin
Published: February 2023

The spread of COVID-19 has presented enormous challenges to higher education students all over the world, prompting these students to switch from face-to-face to online courses. Previous researchers have focused on how university students in specific countries engage in online learning. However, the engagement of university students in online learning on a larger scale has not been thoroughly investigated. This study provides a comprehensive discussion of student engagement in online learning at large higher education institutions around the world during the COVID-19 pandemic. This study focuses university students need to attend university online. Since “engagement” is considered a multidimensional term, this review evaluates studies related to the idea of global university students’ online “engagement” in terms of three unique but interconnected dimensions: behavioral, conscious, and emotional engagement. This review can serve as a reference point for higher education institutions, education policymakers, and teachers in various countries as they work to develop more effective solutions to increase online participation of university students.
Construction and Practice of Smart Textbooks for Vocational Education Courses
Authors: Li Li , Ren Jian , Li Kun
Published: February 2023

The deep integration and mutual promotion of information technology and education have brought new ideas and power to the development of education. Smart textbooks are the comprehensive upgrading of traditional textbook concepts and technologies, the new form of textbooks, and the forefront of textbook construction. Smart textbook is a new form of integrated textbook, which is the combination of traditional paper textbooks and digital resources. Its compilation and development is mainly based on students, and the goal is to cultivate students’ ability to analyze and solve problems. This paper first analyzes the necessity of the construction of smart textbooks, then introduces the connotation and characteristics of smart textbooks, and finally expounds the overall construction ideas of smart textbooks of Aviation Materials Storage Management from many aspects.