bluuebunny/crossref_metadata_2025 huggingface dataset:
Angiotensin Converting Enzyme Inhibitors versus Receptor Blockers in Patients with Ventricular Tachyarrhythmias
Authors: Schupp Tobias , Behnes Michael , Abumayyaleh Mohammad , Weidner Kathrin , Mashayekhi Kambis , Bertsch Thomas , Akin Ibrahim
Published: March 2022

Data investigating the prognostic value of treatment with angiotensin converting enzyme inhibitors (ACEi) and receptor blockers (ARB) usually focusses on patients presenting with heart failure (HF) or acute myocardial infarction (AMI). However, by preventing adverse cardiac remodeling, ACEi/ARB may also decrease the risk of ventricular tachyarrhythmias and sudden cardiac death (SCD). Although ventricular tachyarrhythmias are associated with significant mortality and morbidity, only limited data are available focusing on the prognostic role of ACEi/ARB, when prescribed for secondary prevention of SCD. Therefore, this study comprehensively investigates the role of ACEi versus ARB in patients with ventricular tachyarrhythmias. A large retrospective registry was used including consecutive patients with episodes of ventricular tachycardia (VT) or fibrillation (VF) from 2002 to 2015. The primary prognostic outcome was all-cause mortality at three years, secondary endpoints comprised a composite arrhythmic endpoint (i.e., recurrences of ventricular tachyarrhythmias, ICD therapies and sudden cardiac death) and cardiac rehospitalization. A total of 1236 patients were included (15% treated with ARB and 85% with ACEi) and followed for a median of 4.0 years. At three years, ACEi and ARB were associated with comparable long-term mortality (20% vs. 17%; log rank p = 0.287; HR = 0.965; 95% CI 0.689–1.351; p = 0.835) and comparable risk of the composite arrhythmic endpoint (HR = 1.227; 95% CI 0.841–1.790; p = 0.288). In contrast, ACEi was associated with a decreased risk of cardiac rehospitalization at three years (HR = 0.690; 95% CI 0.490–0.971; p = 0.033). Within the propensity score matched cohort (i.e., 158 patients with ACEi and ARB), ACEi and ARB were associated with comparable long-term outcomes at three years. In conclusion, ACEi and ARB are associated with comparable risk of long-term outcomes in patients presenting with ventricular tachyarrhythmias.
An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape
Authors: Farnell Damian J. J.
Published: March 2022

3D facial surface imaging is a useful tool in dentistry and in terms of diagnostics and treatment planning. Between-group PCA (bgPCA) is a method that has been used to analyse shapes in biological morphometrics, although various “pathologies” of bgPCA have recently been proposed. Monte Carlo (MC) simulated datasets were created here in order to explore “pathologies” of multilevel PCA (mPCA), where mPCA with two levels is equivalent to bgPCA. The first set of MC experiments involved 300 uncorrelated normally distributed variables, whereas the second set of MC experiments used correlated multivariate MC data describing 3D facial shape. We confirmed results of numerical experiments from other researchers that indicated that bgPCA (and so also mPCA) can give a false impression of strong differences in component scores between groups when there is none in reality. These spurious differences in component scores via mPCA decreased significantly as the sample sizes per group were increased. Eigenvalues via mPCA were also found to be strongly affected by imbalances in sample sizes per group, although this problem was removed by using weighted forms of covariance matrices suggested by the maximum likelihood solution of the two-level model. However, this did not solve problems of spurious differences between groups in these simulations, which was driven by very small sample sizes in one group. As a “rule of thumb” only, all of our experiments indicate that reasonable results are obtained when sample sizes per group in all groups are at least equal to the number of variables. Interestingly, the sum of all eigenvalues over both levels via mPCA scaled approximately linearly with the inverse of the sample size per group in all experiments. Finally, between-group variation was added explicitly to the MC data generation model in two experiments considered here. Results for the sum of all eigenvalues via mPCA predicted the asymptotic amount for the total amount of variance correctly in this case, whereas standard “single-level” PCA underestimated this quantity.
Fluid-Structure Interaction of a Foiling Craft
Authors: Marimon Giovannetti Laura , Farousi Ali , Ebbesson Fabian , Thollot Alois , Shiri Alex , Eslamdoost Arash
Published: March 2022

Hydrofoils are a current hot topic in the marine industry both in high performance sailing and in new passenger transport systems in conjunction with electric propulsion. In the sailing community, the largest impact is seen from the America’s cup, where boats are sailed at more than 50 knots (over 100 km/h) with 100% “flying” time. Hydrofoils are also becoming popular in the Olympics, as in the 2024 Olympic games 5 gold medals will be decided on foiling boats/boards. The reason for the increasing popularity of hydrofoils and foiling boats is the recent advances in composite materials, especially in their strength to stiffness ratio. In general, hydrofoils have a very small wetted surface area compared to the wetted surface area of the hull. Therefore, after “take-off” speed, the wetted surface area of the hull, and consequently the resistance of the boat, is reduced considerably. The larger the weight of the boat and crew and the higher the speeds, the greater the loads on the hydrofoils will be. The current research investigates the interaction effects between the fluid and structure of the ZP00682 NACRA 17 Z-foil. The study is carried out both experimentally, in SSPA’s cavitation tunnel, and numerically using a fully coupled viscous solver with a structural analysis tool. The experimental methodology has been used to validate the numerical tools, which in turn are used to reverse engineer the material properties and the internal stiffness of the NACRA 17 foil. The experimental flow speed has been chosen to represent realistic foiling speeds found in the NACRA 17 class, namely 5, 7, and 9 m/s. The forces and the deflection of the Z-foil are investigated, showing a maximum deflection corresponding to 24% of the immersed span. Finally, the effects of leeway and rake angles on the bending properties of the Z-foil are investigated to assess the influence of different angles in sailing strategies, showing that a differential rake set-up might be preferred in search for minimum drag.
Corporate Pro-Environmental Behavior on the Seas: Eco-Ethical Prescriptions of the Largest Cruise Companies
Authors: Ruban Dmitry A. , Yashalova Natalia N.
Published: March 2022

The cruise industry has significant environmental impacts. Ethical prescriptions in codes of conduct of cruise companies can contribute to the development of pro-environmental behaviors. The content of the codes of conduct of the world’s largest cruise companies is analyzed. Seventy percent of these codes bear environmental notions, often in separate sections/subsections. Some of them deal with marine environments. Among the most frequent words in the environment-related passages are those dealing with laws, regulations, and standards, and many common words are too general and vague. A total of 24 environmental topics are established in the analyzed codes, and many of them are either too general or dealing with organizational activities. The results of this study imply that the quality of the eco-ethical prescriptions by the largest cruise companies is moderate, and improvements in the related corporate policy are necessary.
Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan
Authors: Abedini Fateme , Mohammadi Shahla Roudbar , Dahmardehei Mostafa , Ajami Marjan , Salimi Maryam , Khalandi Halala , Mohsenzadegan Monireh , Seif Farhad , Shirvan Bahador Nikoueian , Yaalimadad Sanaz , Roudbary Maryam , Rodrigues Célia F.
Published: March 2022

The mortality and disability-adjusted life years (DALYs) of burn patients are decreasing over time. However, finding novel effective treatment approaches using natural agents is highly considered to reduce the burden of burn injuries. One of the recent agents used in wound healing is β-glucan, mainly extracted from fungi cell walls. This study aimed to evaluate the effect of 5% (m/m) of yeast β-glucan ointment on burn wound healing and to assess the impact of β-glucan on cytokines during the treatment. Thirty-three patients with second or third-degree burns were enrolled in this study. Two groups of twenty-three and ten patients used yeast 5% (m/m) β-glucan ointment (study group) and Stratamed ointment (control), respectively, on a daily basis, for a maximum of four weeks. The size of the burn wounds was measured before and at the end of the treatment. Blood samples of 14 and 10 patients in the β-glucan and control groups, respectively, were obtained before and after the treatment, and the enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum concentration of the IL-4, IL-17, and IFN-γ cytokines. The log-binomial model was used to assess the efficacy of the β-glucan ointment on burn wound healing. ANOVA/ANCOVA was employed to assess the effects of β-glucan on the serum concentration of cytokines. After adjusting for potential confounders/covariates, patients receiving β-glucan had better wound healing (RR = 4.34; 95% CI: 0.73 to 25.67; p = 0.11). There was a significant difference in IL-4 secretion between the β-glucan and control groups after adjusting for potential confounders/covariates (MD = 77.27; 95% CI: 44.73 to 109.82; Cohen’s d = 2.21; 95% CI: 1.16 to 3.24; p = 0.0001). The results indicate that 5% (m/m) of β-glucan has efficacy in burn wound healing, and a significant difference was found in the level of IL-4 after receiving β-glucan. Further studies with a two-arm design and long-term use of ointment are needed to confirm the effect of β-glucan on wound healing and cytokine secretion.
Prognostic Values of Inflammatory Indexes and Clinical Factors in Patients with Epidermal Growth Factor Receptor Mutations in Lung Adenocarcinoma and Treated with Tyrosine Kinase Inhibitors
Authors: Chang Bee-Song , Peng Tai-Chu , Wu Yi-Feng , Hsieh Tsung-Cheng , Huang Chun-Hou
Published: March 2022

This study aimed to access the predictive value of inflammatory indices and clinical factors in toxicity and survival in patients with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma receiving first-line tyrosine kinase inhibitor (TKI)-treatment. A total of 259 patients with stage IIIB–IV lung adenocarcinoma and actionable EGFR mutation who received first-line TKI treatment between 2008 and 2020 were retrospectively enrolled and analyzed. The prognostic factors of TKI-related toxicity, overall survival (OS), and progression-free survival (PFS) were identified by using logistic regression analysis and Cox proportional hazards models. Pre-TKI high platelet-to-lymphocyte ratio (PLR) was associated with post-TKI anemia. Hypoalbuminemia was associated with acneiform rash. Elderly age (≥70 years) and lower body mass index (<18.5 kg/m2) were also associated with hypoalbuminemia. Elderly age, stage IV, EGFR-mutated with L858R and uncommon mutations, and neutrophil-to-lymphocyte ratio were found to be independent prognostic factors for PFS, while elderly age, uncommon EGFR-related mutations, and lymphocyte-to-monocyte ratio were found to be independent prognostic factors for OS. A useful prognostic scoring tool for improving the survival risk stratification of patients was established by incorporating the above essential factors. Baseline hypoalbuminemia and PLR could be crucial clinical assessment factors when initiating TKI therapy. In addition, the optimization of individualized treatment strategies for these patients may be assisted by using the risk-scoring model.
Education and Training of Non-Genetics Providers on the Return of Genome Sequencing Results in a NICU Setting
Authors: East Kelly M. , Cochran Meagan E. , Kelley Whitley V. , Greve Veronica , Finnila Candice R. , Coleman Tanner , Jennings Mikayla , Alexander Latonya , Rahn Elizabeth J. , Danila Maria I. , Barsh Greg , Korf Bruce , Cooper Greg
Published: March 2022

To meet current and expected future demand for genome sequencing in the neonatal intensive care unit (NICU), adjustments to traditional service delivery models are necessary. Effective programs for the training of non-genetics providers (NGPs) may address the known barriers to providing genetic services including limited genetics knowledge and lack of confidence. The SouthSeq project aims to use genome sequencing to make genomic diagnoses in the neonatal period and evaluate a scalable approach to delivering genome sequencing results to populations with limited access to genetics professionals. Thirty-three SouthSeq NGPs participated in a live, interactive training intervention and completed surveys before and after participation. Here, we describe the protocol for the provider training intervention utilized in the SouthSeq study and the associated impact on NGP knowledge and confidence in reviewing, interpreting, and using genome sequencing results. Participation in the live training intervention led to an increased level of confidence in critical skills needed for real-world implementation of genome sequencing. Providers reported a significant increase in confidence level in their ability to review, understand, and use genome sequencing result reports to guide patient care. Reported barriers to implementation of genome sequencing in a NICU setting included test cost, lack of insurance coverage, and turn around time. As implementation of genome sequencing in this setting progresses, effective education of NGPs is critical to provide access to high-quality and timely genomic medicine care.
Fintech and Financial Health in Vietnam during the COVID-19 Pandemic: In-Depth Descriptive Analysis
Authors: Nathan Robert Jeyakumar , Setiawan Budi , Quynh Mac Nhu
Published: March 2022

The growing popularity of smartphones and the proliferation of technology have accelerated the development of the digital payment industry. Fintech enables customers to access financial services more efficiently and faster than traditional business, especially during the COVID-19 pandemic due to health protocols, including restrictions on physical contact. This study investigates financial literacy, fintech adoption, and the impact of the COVID-19 crisis on the financial health of consumers in Vietnam. The relatively higher level of the unbanked population in Vietnam and the lower level of adult financial literacy compared with the ASEAN region motivated this study. Based on judgment sampling, participants were approached using the mall intercept technique, and those familiar with fintech were selected for the research interview. Thirty participants were interviewed and were given a survey form to be filled online using their mobile phones. Data analysis was conducted using IBM SPSS software version 23. Perceived ease of use, perceived usefulness, trust, brand image, government support, user innovativeness, and attitude are found to be significantly correlated with fintech adoption in Vietnam, while financial literacy was found to be not significantly correlated with fintech adoption. Furthermore, further analysis using multiple linear regression revealed user innovativeness and attitude have a positive impact towards fintech adoption, and in contrast, financial literacy showed significant negative impact on fintech. This inverse relationship could indicate that in Vietnam, fintech may play a role of bringing financial inclusion where people with lower financial literacy are able to use technology for financial transactions, which was previously inaccessible to them. This could also mean that Vietnamese with higher financial literacy do not see fintech as an important tool for their financial transactions, as they may already have strong access to traditional financial facilities. This research contributes to knowledge in the field of Fintech adoption in Vietnam at the time of the COVID-19 outbreak. To foster greater financial inclusivity and access for the Vietnamese consumers, policy makers could promote the development of fintech business infrastructure and regulatory sandboxes to foster fintech startups.
Deterministic and Contingent Factors in the Genesis of Agribusiness Clusters: The Pigmeat Industry in Nineteenth-Century Catalonia
Authors: Castell Pere , Ramon-Muñoz Ramon
Published: March 2022

This paper deals with the location, origins, and early development of clusters and industrial districts in the agribusiness sector. It considers the case of the meat processing industry in the second half of the 19th century in Catalonia, a prosperous southern-European region in the period when this industry emerged. By constructing an index of potential locations at the municipal level, the paper discusses whether, and to what extent, deterministic factors explain the genesis of pigmeat processing clusters. The paper concludes that although these latter factors need primary consideration, contingency, particularly human agency, may also play a non-negligible role. As an illustration, this study pays particular attention to the cluster of Vic, which developed around this middle-sized town in central Catalonia. It became a leading meat cluster in early 20th-century Spain, even though it was not better suited to this industry than other Catalan localities where meat companies had also emerged.
Research on the Impact of Factor Flow on Urban Land Use Efficiency from the Perspective of Urbanization
Authors: Lu Xinhai , Shi Zhenxing , Li Jia , Dong Junhao , Song Mingjie , Hou Jiao
Published: March 2022

Researching the impact of factor flow on urban land use efficiency (ULUE) is significant in alleviating the contradiction between the accelerated promotion of urbanization and the inefficient use of urban land. This paper theoretically analyzes the impact mechanism of the flow of the three major factors of production—land, capital, and labor—on ULUE. On this basis, taking 54 cities in the urban agglomeration in the middle and lower reaches of the Yangtze River in China as the research object, the stochastic frontier model, fixed effect model, and K-means clustering method are used to empirically analyze the impact of the flow of labor, capital, and land on ULUE. The heterogeneous effect of factor flow on ULUE in different urbanization stages is also discussed. The results are as follows: (1) Labor flow and capital flow play a significant role in promoting ULUE; land flow plays the opposite role. (2) With the continuous improvement of the level of urbanization, the promotion effect of labor flow first decreases and then increases, while the promotion effect of capital flow continues to decrease, and the inhibitory effect of land flow is significant in the initial stage and expansion stage of urbanization, and the effect increases gradually, but it is not significant in the mature stage. (3) The level of urbanization has an obvious threshold effect on factor flow. There are single thresholds for labor and land flow, and there is a double threshold for capital flow. Research conclusions: we should continue to promote the market-oriented reform of factors, break the institutional shackles which restrict the free flow of factors, implement policies according to the city and the stage, and give full play to the positive impact of factor flow on ULUE.
Indigenous Customary Law and Norwegian Domestic Law: Scenes of a (Complementary or Mutually Exclusive) Marriage?
Authors: Lingaas Carola
Published: March 2022

Articles 27 and 34 of the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP) recognise Indigenous Peoples’ laws. Art. 34 gives Indigenous Peoples the right to maintain their juridical systems or customs in accordance with international human rights standards. Although the UNDRIP is soft law, its core is arguably customary law and, therefore, a binding source of law. For States with Indigenous People, such as Norway, the UNDRIP is of paramount importance, from a legal, political, and not least moral perspective. This paper discusses norm hierarchies and tensions that are created in the meeting between the Indigenous customary law of the Sámi and statutory domestic Norwegian law. The introduction of customary, commonly unwritten, Indigenous rules into the judicial portfolio of a State creates an obvious challenge: what is their legal status? Can Indigenous law set aside domestic statutory norms? Some might argue that due to historical wrong, Indigenous law should always take precedence when domestic law conflicts with it. While Norwegian domestic law acknowledges the precedence of certain core human rights treaties over domestic laws, the same is not valid for Indigenous rights. How then should Indigenous custom be dealt with before a court of law, and how do the different legal systems relate to each other? This paper is foremost based on theoretical, to a lesser degree also on empirical material. It discusses on a general level the relationship between different legal systems within the same State and, on a specific level, the dealing of the Norwegian courts with Sámi Indigenous laws and customs.
Vulnerability and the Quest for Protection: A Review of Canadian Migration Case Law
Authors: Purkey Anna
Published: March 2022

Although the concept of vulnerability has become increasingly prevalent in both domestic and international migration policy in recent years, its precise meaning and implications remain ambiguous and under-examined. Without a coherent understanding of what makes individuals vulnerable, the concept can either act as a justification for additional consideration or reinforce stereotypes of disempowerment. To address this lack of clarity, this article presents the results of an extensive review of Canadian case law. Drawing on data from over 750 cases primarily from the Immigration and Refugee Board and the Federal Court of Canada, this study sought to examine how the concept of vulnerability is used by both decision-makers and parties to cases involving migrants seeking legal status and various forms of protection (including, but not limited to, asylum) under national or international law in Canada. Although an analysis of case law necessarily produces only a partial image of the landscape, this review identified two understandings of vulnerability at play: a procedural one associated with the need to ensure access to justice and a fair hearing, and a substantive one where vulnerability is linked to the categorization of particular groups. In both instances, the recognized importance of the concept is offset by its narrow and inconsistent application and a failure to acknowledge the role that the institutions and mechanisms of “protection” play in creating and perpetuating vulnerability.
How to Treat HR+/HER2- Metastatic Breast Cancer Patients after CDK4/6 Inhibitors: An Unfinished Story
Authors: Cogliati Viola , Capici Serena , Pepe Francesca , di Mauro Pierluigi , Riva Francesca , Cicchiello Federica , Maggioni Claudia , Cordani Nicoletta , Cerrito Maria , Cazzaniga Marina
Published: March 2022

CDK4/6 inhibitors in association with endocrine therapy represent the best therapeutic choice for either endocrine-sensitive or resistant hormone-receptor-positive advanced breast cancer patients. On the contrary, the optimal therapeutic strategy after the failure of CDK4/6 inhibitors-based treatment still remains an open question worldwide. In this review, we analyze the most studied mechanisms of resistance to CDK4/6 inhibitors treatment, as well as the most significant results of retrospective and prospective trials in the setting of progression after CDK4/6 inhibitors, to provide the reader a comprehensive overview from both a preclinical and especially a clinical perspective. In our opinion, an approach based on a deeper knowledge of resistance mechanisms to CDK4/6 inhibitors, but also on a careful analysis of what is done in clinical practice, can lead to a better definition of prospective randomized trials, to implement a personalized sequence approach, based on molecular analyses.
Physical Quality of Life of Sepsis Survivor Severely Malnourished Children after Hospital Discharge: Findings from a Retrospective Chart Analysis
Authors: Sarmin Monira , Alam Tahmina , Shaly Nusrat Jahan , Jeorge Didarul Haque , Afroze Farzana , Shahrin Lubaba , Shahunja K. M. , Ahmed Tahmeed , Shahid Abu Sadat Mohammad Sayeem Bin , Chisti Mohammod Jobayer
Published: March 2022

Background: Quality of life (QoL) among pediatric sepsis survivors in resource-limited countries is poorly understood. We aimed to evaluate the QoL among sepsis survivors, by comparing them with non-sepsis survivors three months after hospital discharge. Methodology: In this retrospective chart analysis with a case–control design, we compared children having sepsis and non-sepsis at hospital admission and during their post-hospitalization life, where the study population was derived from a hospital cohort of 405 severely malnourished children having pneumonia. Results: The median age (months, inter-quartile range) of the children having sepsis and non-sepsis was 10 (5, 17) and 9 (5, 18), respectively. Approximately half of the children among the sepsis survivors had new episodes of respiratory symptoms at home. Though death was significantly higher (15.8% vs. 2.7%, p ≤ 0.001) at admission among the sepsis group, deaths during post-hospitalization life (7.8% vs. 8.8%, p = 0.878) were comparable. A verbal autopsy revealed that before death, most of the children from the sepsis group had respiratory complaints, whereas gastrointestinal complaints were more common among the non-sepsis group. Conclusions: Pediatric sepsis is life-threatening both during hospitalization and post-discharge. The QoL after sepsis is compromised, including re-hospitalization and the development of new episodes of respiratory symptoms especially before death.
Interaction Analysis of MRP1 with Anticancer Drugs Used in Ovarian Cancer: In Silico Approach
Authors: Haque Absarul , Baig Ghazanfar Ali , Alshawli Abdulelah Saleh , Sait Khalid Hussain Wali , Hafeez Bilal Bin , Tripathi Manish Kumar , Alghamdi Badrah Saeed , Mohammed Ali Hani S. H. , Rasool Mahmood
Published: March 2022

Multidrug resistance (MDR) is one of the major therapeutic challenges that limits the efficacy of chemotherapeutic response resulting in poor prognosis of ovarian cancer (OC). The multidrug resistance protein 1 (MRP1) is a membrane-bound ABC transporter involved in cross resistance to many structurally and functionally diverse classes of anticancer drugs including doxorubicin, taxane, and platinum. In this study, we utilize homology modelling and molecular docking analysis to determine the binding affinity and the potential interaction sites of MRP1 with Carboplatin, Gemcitabine, Doxorubicin, Paclitaxel, and Topotecan. We used AutoDock Vina scores to compare the binding affinities of the anticancer drugs against MRP1. Our results depicted Carboplatin < Gemcitabine < Topotecan < Doxorubicin < Paclitaxel as the order of binding affinities. Paclitaxel has shown the highest binding affinity whereas Carboplatin displayed the lowest affinity to MRP1. Interestingly, our data showed that Carboplatin, Paclitaxel, and Topotecan bind specifically to Asn510 residue in the transmembrane domains 1 of the MRP1. Our results suggest that Carboplatin could be an appropriate therapeutic choice against MRP1 in OC as it couples weakly with Carboplatin. Further, our findings also recommend opting Carboplatin with Gemcitabine as a combinatorial chemotherapeutic approach to overcome MDR phenotype associated with recurrent OC.
New Alpha-Amylase Inhibitory Metabolites from Pericarps of Garcinia mangostana
Authors: Alhakamy Nabil Abdulhafiz , Mohamed Gamal Abdallah , Fahmy Usama Ahmed , Eid Basma Ghazi , Ahmed Osama Abdelhakim Aly , Al-Rabia Mohammed Wanees , Khedr Amgad Ibrahim Mansour , Nasrullah Mohammed Zahid , Ibrahim Sabrin Ragab Mohamed
Published: March 2022

Two new benzophenones: garcimangophenones A (6) and B (7) and five formerly reported metabolites were purified from the pericarps EtOAc fraction of Garcinia mangostana ((GM) Clusiaceae). Their structures were characterized by various spectral techniques and by comparing with the literature. The α-amylase inhibitory (AAI) potential of the isolated metabolites was assessed. Compounds 7 and 6 had significant AAI activity (IC50 9.3 and 12.2 µM, respectively) compared with acarbose (IC50 6.4 µM, reference α-amylase inhibitor). On the other hand, 5 had a moderate activity. Additionally, their activity towards the α-amylase was assessed utilizing docking studies and molecular dynamics (MD) simulations. The docking and predictive binding energy estimations were accomplished using reported crystal structure of the α-amylase (PDB ID: 5TD4). Compounds 7 and 6 possessed highly negative docking scores of −11.3 and −8.2 kcal/mol, when complexed with 5TD4, respectively while acarbose had a docking score of −16.1 kcal/mol, when complexed with 5TD4. By using molecular dynamics simulations, the compounds stability in the complexes with the α-amylase was analyzed, and it was found to be stable over the course of 50 ns. The results suggested that the benzophenone derivative 7 may be potential α-amylase inhibitors. However, further investigations to support these findings are required.
Theoretical Roughness Modeling of Hard Turned Surfaces Considering Tool Wear
Authors: Felho Csaba , Varga Gyula
Published: March 2022

Surface roughness is an important factor in metal cutting, and usually different surface roughness characteristics are used to control the quality of the machined surfaces. However, as the cutting tool wears out during the cutting process, the roughness values change. In most cases, theoretical roughness values are calculated without taking the wear characteristics of the tool into account. For this reason, the calculated and measured roughness values may differ from each other, and the tendency of their change may also be different. This paper presents a method for the determination of the theoretical roughness of hard turned surfaces considering the wear of the cutting tool. The purpose of the analyses performed was to show the effect of wear trace on the tool and the roughness of the machined surface and to give a possible method to take the wear into account when calculating the theoretical roughness values. During the investigations, the shape of the actual (worn) edge section of the cutting tool was recorded by an optical microscope, and the theoretical surface roughness values were calculated with that profile by a CAD modeling method developed earlier. Cutting experiments were conducted on a lathe machine with two similar cutting tools, one of them has significant tool wear, while the other was a completely new one. The calculated theoretical roughness values were compared with real measured roughness values, and the error of the estimates was between 8.7 and 68.3%, larger errors were found at lower feeds.
A Novel Fish-Inspired Robot with a Double-Cam Mechanism
Authors: Song Zhibin , Fu Zhongru , Romano Donato , Dario Paolo , Kang Rongjie
Published: March 2022

Fishes have evolved different excellent swimming strategies. To study the influence of tail fin swing on the swimming performance of bionic robot fish, with one joint under the same tail swing frequency and amplitude, we designed a novel robot fish, driven by a double-cam mechanism. By designing the profile of the cam in the mechanism, the robot fish can achieve different undulatory motion trajectory of the caudal fin under the same tail swing frequency and amplitude. The mechanism simulated the undulatory motion of crucian carp. We studied the influence of undulatory motion on the swimming speed of robot fish, which was analyzed by dynamic analysis of the undulatory motion and experiments. According to the experimental results, we can find that the swimming speed of the robotic fish is different under various wave motions. When other conditions are the same, the speed that the robot fish can achieve by imitating the swing motion of the real fish is 1.5 times that of the robot fish doing the cycloid motion. The experimental results correspond to the kinetic analysis results. Furthermore, it is proven that the robot fish with a low caudal peduncle stiffness swims faster under a low swinging frequency, and the speed of a robot fish with a high caudal peduncle stiffness is higher under a high tail swinging frequency.
Optimization of Transfer Quality Factor of Limited-Size Coils for Series-Series Compensated Inductive Power Transfer System
Authors: Liu Peizhou , Gao Tiande , Mao Zhaoyong
Published: March 2022

For an inductive power transfer system, high transfer quality factor means that the system can obtain large theoretical transmission efficiency. In this paper, a method of coil optimization in a limited space to improve the transfer quality factor for a series-series compensated inductive power transfer system is presented. High transfer quality factor in a limited space can be achieved by determining the optimal number of turns with equal turn spacing coil, and then optimizing the distance between adjacent turn. The results of finite element simulation and experimental measurement show that the method proposed in this paper can obtain a higher transfer quality factor than the conventional method of winding coil with equal turn spacing. The method proposed in this paper can be used to guide the optimal design of coils in a limited space.
Construct Six Sigma DMAIC Improvement Model for Manufacturing Process Quality of Multi-Characteristic Products
Authors: Yu Chun-Min , Huang Tsun-Hung , Chen Kuen-Suan , Huang Tsung-Yu
Published: March 2022

After a product has undergone a manufacturing process, it usually has several important quality characteristics. When the process quality of all quality characteristics meets the requirements of the quality level, the process quality of the product can be guaranteed to satisfy customers’ needs. A large number of studies have pointed out that good process quality can raise product yield and product value; at the same time, it can reduce the ratio of rework and scrap, achieve the effect of energy saving and waste reduction, and contribute to the sustainable operation of enterprises as well the environment. Since the six sigma method combines the statistical analysis method of manufacturing cost and production data, it is a useful tool for process improvement and process quality enhancement. Therefore, this paper adopted the six sigma-define, measure, analyze, improve and control (DMAIC) improvement process to lift the manufacturing process quality of multi-characteristic products. Besides, the Taguchi process capability index is one of the commonly used tools for quality assessment in the industry. Not only can it reflect the process loss, but it also can ensure the process yield when the index value is large enough. Consequently, this paper discussed the relationship between the Taguchi process capability index and the six sigma quality level. Meanwhile, the entire six sigma DMAIC improvement process was built on the basis of the process capability index and developed by the method of statistical quality control. Hence, the proposed method is very convenient for process engineers to apply, as well as is helpful for enterprises to move toward the goal of smart manufacturing and sustainability.
An Efficient Technique of Fractional-Order Physical Models Involving ρ-Laplace Transform
Authors: Shah Nehad Ali , Dassios Ioannis , El-Zahar Essam R. , Chung Jae Dong
Published: March 2022

In this article, the ρ-Laplace transform is paired with a new iterative method to create a new hybrid methodology known as the new iterative transform method (NITM). This method is applied to analyse fractional-order third-order dispersive partial differential equations. The suggested technique procedure is straightforward and appealing, and it may be used to solve non-linear fractional-order partial differential equations effectively. The Caputo operator is used to express the fractional derivatives. Four numerical problems involving fractional-order third-order dispersive partial differential equations are presented with their analytical solutions. The graphs determined that their findings are in excellent agreement with the precise answers to the targeted issues. The solution to the problems at various fractional orders is achieved and found to be correct while comparing the exact solutions at integer-order problems. Although both problems are the non-linear fractional system of partial differential equations, the present technique provides its solution sophisticatedly. Including both integer and fractional order issues, solution graphs are carefully drawn. The fact that the issues’ physical dynamics completely support the solutions at both fractional and integer orders is significant. Moreover, despite using very few terms of the series solution attained by the present technique, higher accuracy is observed. In light of the various and authentic features, it can be customized to solve different fractional-order non-linear systems in nature.
Performance Degradation Based on Importance Change and Application in Dissimilar Redundancy Actuation System
Authors: Zhang Yadong , Zhang Chao , Wang Shaoping , Chen Rentong , Tomovic Mileta M.
Published: March 2022

The importance measure is a crucial method to identify and evaluate the system weak link. It is widely used in the optimization design and maintenance decision of aviation, aerospace, nuclear energy and other systems. The dissimilar redundancy actuation system (DRAS) is a key aircraft control subsystem which performs aircraft attitude and flight trajectory control. Its performance and reliability directly affect the aircraft flight quality and flight safety. This paper considers the influence of the Birnbaum importance measure (BIM) and integrated importance measure (IIM) on the reliability changes of key components in DRAS. The differences of physical fault characteristics of different components due to performance degradation and power mismatch, are first considered. The reliability of each component in the system is then estimated by assuming that the stochastic degradation process of the DRAS components follows an inverse Gaussian (IG) process. Finally, the weak links of the system are identified using BIM and IIM, so that the resources can be reasonably allocated to the weak links during the maintenance period. The proposed method can provide a technical support for personnel maintenance, in order to improve the system reliability with a minimal lifecycle cost.
Effect of Direct Oral Anticoagulants on Treatment of Geriatric Hip Fracture Patients: An Analysis of 15,099 Patients of the AltersTraumaRegister DGU®
Authors: Aigner Rene , Buecking Benjamin , Hack Juliana , Schwenzfeur Ruth , Eschbach Daphne , Einheuser Jakob , Schoeneberg Carsten , Pass Bastian , Ruchholtz Steffen , Knauf Tom ,   on behalf of the Registry for Geriatric Trauma (ATR-DGU)
Published: March 2022

Background and Objectives: The increased use of direct oral anticoagulants (DOACs) results in an increased prevalence of DOAC treatment in hip fractures patients. However, the impact of DOAC treatment on perioperative management of hip fracture patients is limited. In this study, we describe the prevalence of DOAC treatment in a population of hip fracture patients and compare these patients with patients taking vitamin K antagonists (VKA) and patients not taking anticoagulants. Materials and Methods: This study is a retrospective analysis from the Registry for Geriatric Trauma (ATR-DGU). The data were collected prospectively from patients with proximal femur fractures treated between January 2016 and December 2018. Among other factors, anticoagulation was surveyed. The primary outcome parameter was time-to-surgery. Further parameters were: type of anesthesia, surgical complications, soft tissue complications, length of stay and mortality. Results: In total, 11% (n = 1595) of patients took DOACs at the time of fracture, whereas 9.2% (n = 1325) were on VKA therapy. During the study period, there was a shift from VKA to DOACs. The time-to-surgery of patients on DOACs and of patients on VKA was longer compared to patients who did not take any anticoagulation. No significant differences with regard to complications, type of anesthesia and mortality were found between patients on DOACs compared to VKA treatment. Conclusion: An increased time-to-surgery in patients taking DOACs and taking VKA compared to non-anticoagulated patients was found. This underlines the need for standardized multi-disciplinary orthopedic, hematologic and ortho-geriatric algorithms for the management of hip fracture patients under DOAC treatment. In addition, no significant differences regarding complications and mortality were found between DOAC and VKA users. This demonstrates that even in the absence of widely available antidotes, the safe management of geriatric patients under DOACs with proximal femur fractures is possible.
Microendoscopic Lumbar Posterior Decompression Surgery for Lumbar Spinal Stenosis: Literature Review
Authors: Suzuki Akinobu , Nakamura Hiroaki
Published: March 2022

Lumbar spinal stenosis (LSS) is a common disease in the elderly, mostly due to degenerative changes in the lumbar spinal complex. Decompression surgery is the standard surgical treatment for LSS. Classically, total laminectomy—which involves resection of the spinous process, entire laminae and medial facet—has been the standard decompression technique; however, it can cause post-surgical instability. To overcome this disadvantage, various minimally invasive techniques that preserve the stabilization structures of the spine have been developed, and surgeons have begun to re-evaluate decompression surgery from the standpoint of reduced invasiveness and cost. More than two decades have passed since the introduction of microendoscopic spine surgery, and studies continue to shed light on its advantages and limitations as new knowledge becomes available. This article is a narrative review of the available literature, along with authors’ experience, regarding the indications, surgical techniques, clinical outcomes, and limitations/complications of microendoscopic decompression for LSS.
Semantic Segmentation Dataset for AI-Based Quantification of Clean Mucosa in Capsule Endoscopy
Authors: Ju Jeong-Woo , Jung Heechul , Lee Yeoun Joo , Mun Sang-Wook , Lee Jong-Hyuck
Published: March 2022

Background and Objectives: Capsule endoscopy (CE) for bowel cleanliness evaluation primarily depends on subjective methods. To objectively evaluate bowel cleanliness, we focused on artificial intelligence (AI)-based assessments. We aimed to generate a large segmentation dataset from CE images and verify its quality using a convolutional neural network (CNN)-based algorithm. Materials and Methods: Images were extracted and divided into 10 stages according to the clean regions in a CE video. Each image was classified into three classes (clean, dark, and floats/bubbles) or two classes (clean and non-clean). Using this semantic segmentation dataset, a CNN training was performed with 169 videos, and a clean region (visualization scale (VS)) formula was developed. Then, measuring mean intersection over union (mIoU), Dice index, and clean mucosal predictions were performed. The VS performance was tested using 10 videos. Results: A total of 10,033 frames of the semantic segmentation dataset were constructed from 179 patients. The 3-class and 2-class semantic segmentation’s testing performance was 0.7716 mIoU (range: 0.7031–0.8071), 0.8627 Dice index (range: 0.7846–0.8891), and 0.8927 mIoU (range: 0.8562–0.9330), 0.9457 Dice index (range: 0.9225–0.9654), respectively. In addition, the 3-class and 2-class clean mucosal prediction accuracy was 94.4% and 95.7%, respectively. The VS prediction performance for both 3-class and 2-class segmentation was almost identical to the ground truth. Conclusions: We established a semantic segmentation dataset spanning 10 stages uniformly from 179 patients. The prediction accuracy for clean mucosa was significantly high (above 94%). Our VS equation can approximately measure the region of clean mucosa. These results confirmed our dataset to be ideal for an accurate and quantitative assessment of AI-based bowel cleanliness.
Annihilation Mechanism of Low-Angle Grain Boundary in Nanocrystalline Metals
Authors: Zhou Guofeng , Huang Qishan , Chen Yingbin , Yu Xiongqing , Zhou Haofei
Published: March 2022

Due to the high density of grain boundaries (GBs), nanocrystalline metals possess superior properties, including enhanced strength, work hardening, and fatigue resistance, in comparison to their conventional counterparts. The expectation of GB migration is critical for grain coarsening and GB annihilation in these materials, significantly affecting the polycrystalline network and mechanical behavior. Here, we perform molecular dynamics (MD) simulations on gold (Au) nanocrystals containing multiple parallelly arranged GBs, with a focus on the investigation of annihilation mechanisms of low-angle grain boundaries (LAGBs). It is observed that the shear-coupled motion of LAGBs, consisting of dislocations, gives rise to their preliminary migration with the reduced separation distance between GBs. With subsequent GB motion, the LAGBs encountered with neighboring GBs, and can be annihilated by various mechanisms, including dislocations interpenetration, dislocations interaction, or dislocations absorption, depending on the specific configuration of the neighboring GB. These findings enhance our understanding of GB interactions and shed light on the controlled fabrication of high-performance nanocrystalline metals.
Inanimate Surfaces and Air Contamination with Multidrug Resistant Species of Staphylococcus in the Neonatal Intensive Care Unit Environment
Authors: Menezes Ralciane de Paula , Marques Lara de Andrade , Silva Felipe Flávio , Silva Nagela Bernadelli Sousa , Alves Priscila Guerino Vilela , Bessa Meliza Arantes de Souza , Araújo Lúcio Borges de , Penatti Mário Paulo Amante , Pedroso Reginaldo dos Santos , Brito Röder Denise Von Dolinger de
Published: March 2022

Background: Contamination of the hospital environment with multi-resistant (MDR) Staphylococcus increases the risk of infection. The aim of this study is to identify the MDR species of Staphylococcus on inanimate surfaces, in air, and in clinical samples, and analyze the risk factors that correlate with the occurrence of infections in a Neonatal Intensive Care Unit. Methods: Samples of inanimate surfaces and air were taken using a premoistened swab (0.9% sodium chloride) and spontaneous air sedimentation, respectively. The clinical isolates were recovered from infected neonates. The isolates (environmental and clinical) were identified by matrix-assisted laser desorption ionization-time of flight and the resistance profile was calculated using the disk diffusion agar technique. Results: In total, 181 isolates were obtained, 93 from (surfaces), 18 from the air, and 70 clinical samples. S. epidermidis was the most frequent species (66.8%), and the failure rate in air cleaning was 100%. More than 60% of the isolates were MDR, and the majority of clinical isolates (60.4%) had a resistance profile identical to that of the environmental isolates. Conclusion: Staphylococcus spp. were found in most of the analyzed samples, with a high frequency of MDR isolates, demonstrating the importance of the hospital environment as a reservoir, and the need for infection control measures, and rational use of antimicrobials.