bluuebunny/crossref_metadata_2025 huggingface dataset:
Soil Microbial Community Characteristics and Their Effect on Tea Quality under Different Fertilization Treatments in Two Tea Plantations
Authors: Lei Yu , Ding Ding , Duan Jihua , Luo Yi , Huang Feiyi , Kang Yankai , Chen Yingyu , Li Saijun
Published: May 2024

Fertilization is an essential aspect of tea plantation management that supports a sustainable tea production and drastically influences soil microbial communities. However, few research studies have focused on the differences of microbial communities and the variation in tea quality in response to different fertilization treatments. In this work, the soil fertility, tea quality, and soil microbial communities were investigated in two domestic tea plantations following the application of chemical and organic fertilizers. We determined the content of mineral elements in the soil, including nitrogen, phosphorus, and potassium, and found that the supplementation of chemical fertilizer directly increased the content of mineral elements. However, the application of organic fertilizer significantly improved the accumulation of tea polyphenols and reduced the content of caffeine. Furthermore, amplicon sequencing results showed that the different ways of applying fertilizer have limited effect on the alpha diversity of the microbial community in the soil while the beta diversity was remarkably influenced. This work also suggests that the bacterial community structure and abundance were also relatively constant while the fungal community structure and abundance were dramatically influenced; for example, Chaetomiaceae at the family level, Hypocreaceae at the order level, Trichoderma at the genus level, and Fusarium oxysporum at the species level were predominantly enriched in the tea plantation applying organic fertilizer. Moreover, the bacterial and fungal biomarkers were also analyzed and it was found that Proteobacteria and Gammaproteobacteria (bacteria) and Tremellomycetes (fungi) were potentially characterized as biomarkers in the plantation under organic fertilization. These results provide a valuable basis for the application of organic fertilizer to improve the soil of tea plantations in the future.
Association between Bone Quality and Physical Activity in Community-Dwelling Older Adults
Authors: Akai Koki , Nagai Koutatsu , Tsuji Shotaro , Hirose Katsuyoshi , Maruyama Daisuke , Matsuzawa Ryota , Tamaki Kayoko , Kusunoki Hiroshi , Wada Yosuke , Shinmura Ken
Published: May 2024

Bone quality is an essential factor determining bone strength. However, the relationship between physical activity (PA) and bone quality remains unclear. This study aimed to ascertain the relationship between bone quality and PA using a cortical bone quantitative ultrasound device that measures components of bone quality. In this cross-sectional study, bone quality was assessed in community-dwelling older adults by measuring the cortical speed of sound (cSOS) at the mid-tibia using a quantitative ultrasound device. Using a wrist-worn accelerometer, we calculated the daily duration of moderate-to-vigorous physical activity (MVPA) and light physical activity (LPA) based on estimated METs from the accelerometer data, without differentiating between types of activities. A multiple regression analysis was performed to examine the association between PA and the cSOS. The participants’ physical activity averaged 42.0 min/day for MVPA and 483.6 min/day for LPA. No significant association was observed between PA and bone quality in either men or women in the crude models. Furthermore, PA was not significantly correlated with the cSOS in the models adjusted for age, body mass index, nutrient intake, number of medications, and kidney disease. This study was a cross-sectional study which focused on the association between bone quality in older adults and their current amount of PA. The cSOS, as a measure of bone quality, was not associated with PA in men or women. Higher amounts of daily PA, as estimated from metabolic equivalents with an accelerometer, may not necessarily maintain or improve bone quality in older adults. This study does not rule out the potential for a positive association between PA levels or types and bone quality in younger or middle-aged individuals. It was specifically targeted at older adults, and its findings should not be generalized to younger populations. Further longitudinal studies are required to better understand the relationship between PA and bone quality.
Consumers’ Perceptions for an Outdoor Ornamental Plant: Exploring the Influence of Novel Plant Diseases Diagnostics and Sustainable Nurseries Cultivation Management
Authors: Frem Michel , Petrontino Alessandro , Fucilli Vincenzo , De Lucia Barbara , Tria Emanuela , Campobasso Adele Annarita , Calderoni Federica , Bozzo Francesco
Published: May 2024

A discrete choice experiment was conducted to assess the perceptions and willingness-to-pay of Italian consumers regarding plant diagnosis and sustainable cultivation attributes in outdoor ornamental plants, specifically Abelia × grandiflora. The results revealed that most Italian consumers place great importance on the health of ornamental plants during the purchasing process, with a preference for obtaining them from nursery facilities. Additionally, they demonstrated a willingness to pay a price premium for innovative plant diagnosis and sustainable cultivation in the production of A. × grandiflora, amounting to EUR 1.10 and EUR 0.90, respectively. These findings have significant implications for (i) nursery growers, enabling them to shape their sustainable nursery management and marketing strategies, and (ii) policymakers, facilitating the enhancement of communication strategies and the implementation of awareness campaigns aimed at promoting the sale of healthy Italian ornamental species, following the current EU regulation 2020/1201.
A Modified Enthalpic Lattice Boltzmann Method for Simulating Conjugate Heat Transfer Problems in Non-Homogeneous Media
Authors: Matsuda Vinicius Akyo , Martins Ivan Talão , Moreira Debora Carneiro , Cabezas-Gómez Luben , Bandarra Filho Enio Pedone
Published: May 2024

In this study, we introduced modifications to a prior existing enthalpic lattice Boltzmann method (LBM) tailored for simulating the conjugate heat transfer phenomena in non-homogeneous media with time-dependent thermal properties. Our approach is based upon the incorporation of the remaining terms of a conservative energy equation, excluding only the terms regarding flow compressibility and viscous dissipation, thereby accounting for the local and transient variations in the thermophysical properties. The solutions of verification tests, comprising assessments of both transient and steady-state solutions, validated the accuracy of the proposed model, further bolstering its reliability for analyzing heat transfer processes. The modified model was then used to perform an analysis on structured cavities under free convection, revealing compelling insights, particularly regarding transient regimes, demonstrating that the structured cavities exhibit a beneficial impact on enhancing the heat transfer processes, hence providing insights for potential design enhancements in heat exchangers. These results demonstrate the potential of our modified enthalpic LBM approach for simulating complex heat transfer phenomena in non-homogeneous media and structured geometries, offering valuable results for heat exchanger engineering and optimization.
Efficiency in Operations of NASDAQ Listed Technology Companies from 2011 to 2023
Authors: Maheshwari Suneel , Naik Deepak Raghava
Published: May 2024

The performance of technology companies listed on NASDAQ significantly impacts larger economic trends. Investors need specific information to navigate market volatility and make informed decisions in an increasingly complex marketplace. Furthermore, amidst the ongoing digital revolution, legislators and regulatory agencies must comprehend the operational dynamics of technology companies to develop frameworks that support innovation while maintaining market stability. Our study assesses the impact on the overall operational efficiency of NASDAQ-listed firms from 2011 to 2023, resulting from the interdependence of critical variables such as selling, general, and administrative expenses (SGA), cost of goods and services sold (COGS), and investments in research and development (R&D). Johansen’s cointegration methodology and pairwise Granger causality tests were employed to unveil long-term relationships, equilibrium adjustments, and causal relationships among the considered variables. The results provide critical insights into the strategic management of operational variables by the listed companies. The economic significance of the results obtained underscores the paramount importance of efficiently managing the cost of goods and services sold to achieve superior operating performance among these leading technology firms.
A Stratal Phonological Analysis of Stem-Level and Word-Level Effects in Old French Compensatory Vowel Lengthening upon Coda /s/ Deletion
Authors: Montaño Francisco Antonio
Published: May 2024

The well-known deletion of coda sibilants in Old French (11th–14th centuries) induced a compensatory lengthening effect on the preceding vowel, generally described as applying uniformly where coda /s/ was lost. This study highlights and analyzes phonological contexts where lengthening likely did not occur, examining their interaction with stress assignment, vowel quality, schwa adjustment, prothesis, and morphological structure. The Stratal OT analysis formalizes the proposed pattern differentiating the long and short vowel reflexes identified especially for mid vowels: while categorical in tonic syllables and low vowels /a, ɑ/ irrespective of stress, lengthening only prevails in atonic mid vowels when coda /s/ deletion impacts a syllable assigned stress within the specific stratal phonological cycle when /s/ is deleted from input. The resulting length is transmitted and preserved in subsequent stratal cycles regardless of eventual word-level stress reassignment, especially (but not exclusively) because of word-level schwa adjustment, allowing a shift to word-final stress and producing an opacity effect of a long atonic mid vowel inherited from an earlier cycle. The stratal account formalizes observed analogical effects between lexical items and derived forms with respect to vowel quality and length and proposes them to result instead from the interplay of morphology and phonology.
Improvement in Grain Size Distribution Uniformity for Nuclear-Grade Austenitic Stainless Steel through Thermomechanical Treatment
Authors: Wang Yong , Xue Weiwei , Pang Zongxu , Zhao Zichen , Liu Zhuohua , Liu Chenyuan , Gao Fei , Li Weijuan
Published: May 2024

In this work, thermomechanical treatment (single-pass rolling at 800 °C and solution treatment) was applied to nuclear-grade hot-rolled austenitic stainless steel to eliminate the mixed grain induced by the uneven hot-rolled microstructure. By employing high-temperature laser scanning confocal microscopy, microstructure evolution during solution treatment was observed in situ, and the effect of single-pass rolling reduction on it was investigated. In uneven hot-rolled microstructure, the millimeter-grade elongated grains (MEGs) possessed an extremely large size and a high Schmid factor for slip compared to the fine grains, which led to greater plastic deformation and increased dislocation density and deformation energy storage during single-pass rolling. During subsequent solution treatment, there were fewer nucleation sites for the new grain, and the grain boundary (GB) was the main nucleation site in MEGs at a lower rolling reduction. In contrast, at a higher reduction, increased uniformly distributed rolling deformation and more nucleation sites were developed in MEGs. As the reduction increased, the number of in-grain nucleation sites gradually exceeded that of GB nucleation sites, and in-grain nucleation preferentially occurred. This was beneficial for promoting the refinement of new recrystallized grains and a reduction in the size difference of new grains during recrystallization. The single-pass rolling reduction of 15–20% can effectively increase the nucleation sites and improve the uniformity of rolling deformation distribution in the MEGs, promote in-grain nucleation, and finally refine the abnormally coarse elongated grain, and eliminate the mixed-grain structure after solution treatment.
Special Issue: Damage Analysis for Composite Materials: Methods, Testing and Evaluation
Authors: Durão Luis M. P. , Loureiro Nuno C.
Published: May 2024

After the Stone, the Bronze, and the Iron Ages, material history is now in the Composite Age [...]
Microstructure Evolution and Strengthening Mechanism of Dual-Phase Mg–8.3Li–3.1Al–1.09Si Alloys during Warm Rolling
Authors: Wang Ying , Wu Guangying , Liang Bingbing , He Yongquan , Liu Changhong , Liu Junwei , Wei Guobing
Published: May 2024

In this study, the rolling process of the warm-rolled duplex-phase Mg–8.3Li–3.1Al–1.09Si alloy and the strengthening mechanism of as-rolled Mg–Li alloy were investigated. The highest ultimate tensile strength (UTS, 323.66 ± 19.89 MPa) could be obtained using a three-pass rolling process with a 30% thickness reduction for each pass at 553 K. The strength of the as-rolled LAS831 alloy is determined by a combination of second-phase strengthening, grain refinement strengthening, dislocation strengthening, and load-transfer reinforcement. Of these factors, dislocation strengthening, which is caused by strain hardening of the α-Mg phase, can produce a good strengthening effect but also cause a decrease in plasticity. The Mg2Si phase is broken up into particles or strips during the rolling process. After three passes, the AlLi particles were transformed into an AlLi phase, and the Mg2Si particles and nanosized AlLi particles strengthened the second phase to form a hard phase. The average size of the DRXed β-Li grains decreased with each successive rolling pass, and the average size of recrystallized grains in the three-pass-rolled LAS831 alloy became as low as 0.27 μm. The interface between the strip-like Mg2Si phase and the α-Mg phase is characterized by semicoherent bonding, which can promote the transfer of tensile and shear forces from the matrix to the strip-like Mg2Si phase, thereby improving the strength of the matrix and thus strengthening the LAS831 alloy.
Phase Fraction Estimation in Multicomponent Alloy from EDS Measurement Data
Authors: Burbelko Andriy , Wiktor Tomasz , Garbacz-Klempka Aldona , Ziółkowski Eugeniusz
Published: May 2024

To perform quality assessments of both metal alloys and many other engineering materials, measurements of the volume fractions of phases or microstructure components are utilized. For this purpose, quantitative analysis of the evaluated components’ distribution on metallographic specimens is often employed. Phases or components of the microstructure are identified based on the variation in signal received in the band of light seen. Problems with the correct identification of measurement results in this spectral band can be caused by the inhomogeneity of the etching when the alloy components are segregated. Additional uncertainty arises when the analyzed image pixel contains a boundary between grains of different phases. This article attempts to use the results of local chemical composition measurements as a source signal for quantitative evaluation of phase composition. For this purpose, quantitative maps of elemental concentration distributions, obtained with a Tescan Mira GMU high-resolution scanning electron microscope in QuantMap mode, were used as input data for the phase composition evaluation of an EN AC 46000 alloy sample. The X-ray microanalysis signal generation area may contain grains of more than one phase. Therefore, evaluation of the phase fractions in areas of individual measurements were calculated by looking for the minimum of the objective function, calculated as the sum of the squares of the deviations of the results of measurements of the concentration of individual elements from the weighted average values of solubilities of these elements in the phases.
Performance of Sustainable Green Concrete Incorporating Quarry Dust and Ferronickel Slag as Fine Aggregate
Authors: Nuruzzaman Md , Almeida Jaydon , Amin Md Tanvir Ehsan , Sarker Prabir Kumar
Published: May 2024

This paper presents a study on the combined use of two by-products, namely quarry dust (QD) and ferronickel slag (FNS), as a full substitute for natural sand to improve the greenness of concrete production. Quarry dust was used in increments of 25% to a maximum of 75% substitution, where nickel slag was used as the remaining proportion of fine aggregate. All the combinations of quarry dust and nickel slag were found to be compliant with AS 2758.1 and they showed notably better grading than 100% sand. In this research, standard concrete tests, such as the slump test for fresh concrete, and compression, tensile and shrinkage tests for hardened concrete, were conducted. Scanning electron microscopy and X-ray diffraction analysis were also conducted for microstructural investigation. The results concluded that the combinations of quarry dust and nickel slag in concrete as a whole substitution of sand provide similar results for these properties. Specifically, 25% quarry dust with 75% nickel slag proved to be the most promising alternative to sand, with compressive and splitting tensile strengths of 62 and 4.29 MPa, respectively, which were 16% and 20% higher than those of the control mix. Also, lower drying shrinkage was observed for this combination compared to the control mix. The higher strength is attributed to the rough texture and angular shape of both quarry dust and nickel slag providing a better mechanical interlocking. The validity of this result has also been confirmed through image analysis of micrographs from various specimens. In microstructural investigations, specimens with QD and FNS exhibited fewer voids and a more compact surface compared to the control specimen. This shows the potential for further research into the use of quarry dust and nickel slag in the production of green concrete.
Bone-to-Implant Contact in Implants with Plasma-Treated Nanostructured Calcium-Incorporated Surface (XPEEDActive) Compared to Non-Plasma-Treated Implants (XPEED): A Human Histologic Study at 4 Weeks
Authors: Makary Christian , Menhall Abdallah , Lahoud Pierre , Yang Kyung Ran , Park Kwang Bum , Razukevicius Dainius , Traini Tonino
Published: May 2024

Titanium implants undergo an aging process through surface hydrocarbon deposition, resulting in decreased wettability and bioactivity. Plasma treatment was shown to significantly reduce surface hydrocarbons, thus improving implant hydrophilicity and enhancing the osseointegration process. This study investigates the effect of plasma surface treatment on bone-to-implant contact (BIC) of implants presenting a nanostructured calcium-incorporated surface (XPEED®). Following a Randomized Controlled Trial (RCT) design, patients undergoing implant surgery in the posterior maxilla received additional plasma-treated (n = 7) or -untreated (n = 5) 3.5 × 8 mm implants that were retrieved after a 4-week healing period for histological examination. Histomorphometric analysis showed that plasma-treated implants exhibited a 38.7% BIC rate compared to 22.4% of untreated implants (p = 0.002), indicating enhanced osseointegration potential. Histological images also revealed increased bone formation and active osteoblastic activity around plasma-treated implants when compared to untreated specimens. The findings suggest that plasma treatment improves surface hydrophilicity and biological response, facilitating early bone formation around titanium implants. This study underscores the importance of surface modifications in optimizing implant integration and supports the use of plasma treatment to enhance osseointegration, thereby improving clinical outcomes in implant dentistry and offering benefits for immediate and early loading protocols, particularly in soft bone conditions.
Stimulation of Biological Structures on the Nanoscale Using Interfaces with Large Built-In Spontaneous Polarizations
Authors: Zia Nida , Stroscio Michael , Dutta Mitra
Published: May 2024

The electric potential stimulation of biological structures in aqueous environments is well-known to be a result of the gating of voltage-gated ion channels. Such voltage-gated ion channels are ubiquitous in the membranes of a wide variety of cells and they play central roles in a wide variety of sensing mechanisms and neuronal functions in biological systems. Experimental studies of ion-channel gating are frequently conducted using path-clamp techniques by placing a cumbersome external electrode in the vicinity of the extracellular side of the ion channel. Recently, it has been demonstrated that laser-induced polarization of nanoscale quantum dots can produce voltage sufficient to gate voltage-gated ion channels. This study specifically focuses on a new method of gating voltage-gated ion channels using 2D structures made of materials exhibiting large naturally occurring spontaneous polarizations, thereby eliminating the need for an external electrode or an illuminating laser. The work presents the use of self-polarizing semiconductor flakes, namely, 2H-SiC, ZnO, and GaN, to produce electric potential that is sufficient to gate voltage-gated ion channels when existing in proximity to it.
The Influence of the Addition of Basalt Powder on the Properties of Foamed Geopolymers
Authors: Łach Michał , Kozub Barbara , Bednarz Sebastian , Bąk Agnieszka , Melnychuk Mykola , Masłoń Adam
Published: May 2024

Geopolymers are binder materials that are produced by a chemical reaction between silica or aluminum compounds with an alkaline activating solution. Foamed geopolymer materials are increasingly being cited as a viable alternative to popular organic insulation materials. Since the foaming process of geopolymers is difficult to control, and any achievements in improving the performance of such materials are extremely beneficial, this paper presents the effect of the addition of basalt powder on the properties of foamed geopolymers. This paper presents the results of physicochemical studies of fly ash and basalt, as well as mechanical properties, thermal properties, and structure analysis of the finished foams. The scope of the tests included density tests, compressive strength tests, tests of the thermal conductivity coefficient using a plating apparatus, as well as microstructure tests through observations using light and scanning microscopy. Ground basalt was introduced in amounts ranging from 0 to 20% by mass. It was observed that the addition of basalt powder contributes to a reduction in and spheroidization of pores, which directly affect the density and pore morphology of the materials tested. The highest density of 357.3 kg/m3 was characterized by samples with a 5 wt.% basalt powder addition. Their density was 14% higher than the reference sample without basalt powder addition. Samples with 20 wt.% basalt addition had the lowest density, and the density averaged 307.4 kg/m3. Additionally, for the sample containing 5 wt.% basalt powder, the compressive strength exceeded 1.4 MPa, and the thermal conductivity coefficient was 0.1108 W/m × K. The effect of basalt powder in geopolymer foams can vary depending on many factors, such as its chemical composition, grain size, content, and physical properties. The addition of basalt above 10% causes a decrease in the significant properties of the geopolymer.
Lightweight Designs and Improving the Load-Bearing Capacity of Structures by the Method of Aggregation
Authors: Todinov Michael
Published: May 2024

The paper introduces a powerful method for developing lightweight designs and enhancing the load-bearing capacity of common structures. The method, referred to as the ‘method of aggregation’, has been derived from reverse engineering of sub-additive and super-additive algebraic inequalities. The essence of the proposed method is consolidating multiple elements loaded in bending into a reduced number of elements with larger cross sections but a smaller total volume of material. This procedure yields a huge reduction in material usage and is the first major contribution of the paper. For instance, when aggregating eight load-carrying beams into two beams supporting the same total load, the material reduction was more than 1.58 times. The second major contribution of the paper is in demonstrating that consolidating multiple elements loaded in bending into a reduced number of elements with larger cross sections but the same total volume of material leads to a big increase in the load-bearing capacity of the structure. For instance, when aggregating eight cantilevered or simply supported beams into two beams with the same volume of material, the load-bearing capacity until a specified tensile stress increased twice. At the same time, the load-bearing capacity until a specified deflection increased four times.
Phenotype and Clinicoradiological Differences in Multifocal and Focal Bronchiectasis
Authors: Jankovic Jelena , Jandric Aleksandar , Djurdjevic Natasa , Vukosavljevic Dragan , Bojic Zlatan , Zecevic Andrej , Stjepanovic Mihailo
Published: May 2024

Introduction: Bronchiectasis is a chronic progressive respiratory disease characterized by permanent dilatation of the bronchi. It is a complex condition with numerous different etiologies, co-morbidities, and a heterogeneous presentation. As we know, there is a lack of studies that describe the differences and compare the characteristics between focal and multifocal bronchiectasis. The aim of this study is to identify differences in clinical characteristics presentation, severity or distribution in focal and multifocal bronchiectasis, and prognostic implications. Methods: 126 patients with computed tomography (CT)-verified bronchiectasis were enrolled. Baseline characteristics that included age, sex, smoking history, and respiratory symptoms were recorded, with special attention paid to hemoptysis appearance, body mass index, and comorbidities. The type of bronchiectasis determined by CT scan and the modified Reiff scores indicating radiological severity were recorded. Patients were divided in two groups (I is focal and II is multifocal). Results: There were no statistically significant differences in age, smoking status, comorbidity, and BMI between the two groups. Multifocality was associated with a significantly higher proportion of females (p = 0.014), the rate of hemoptysis (p = 0.023), and the number of hospitalizations, but not of exacerbations and prevalence of immunodeficiency (p = 0.049). Significantly, a high number of subjects with multifocality had bronchiectasis of moderate severity, and post-infective and asthma-associated phenotypes were the dominant in this group. Unexpectedly, the cystic and varicose radiological phenotype (which need more time to develop) were more dominant in the focal group. The cylindrical phenotype was equally observed in the multifocal and focal groups. Conclusions: Our study suggests that multifocality is not related to age, number of exacerbations, or radiological phenotype, but it seems to be associated with the clinical post-infective phenotype, immunodeficiency, frequent hospitalizations, and severity. Thus, the presence of multifocal bronchiectasis may act as a biomarker of severity and poor outcomes in these patients.
Nonsuicidal Self-Injury and Suicidal Beliefs in Adolescent Inpatient
Authors: Kostic Jelena , Žikić Olivera , Djordjević Vladimir , Ristić Aleksandra , Krivokapić Žilijeta
Published: May 2024

Background and Objectives: Although nonsuicidal self-injury (NSSI), by definition, excludes suicidal intent, numerous studies show associations between NSSI and suicidal phenomena in clinical and outpatient adolescent samples. Given the growing interest in the relationship between NSSI and suicidal phenomena, the present study aimed to investigate the relationship between NSSI and suicidal beliefs in adolescent psychiatric inpatients. Materials and Methods: The study sample included 50 adolescent inpatients at a specialized facility, with a mean age of 15.44 ± 1.39, who fulfilled DSM-5 criteria for NSSI. For study purposes, we use the Ottawa Self-Injury Inventory (OSI) and Brief Suicide Cognitions Scale (B-SCS). Statistical data processing was performed in the R software 4.3.0 (R Core Team, Vienna, Austria). Results: Of all NSSI functions, the Internal ER function score was the highest (18.72 ± 7.08), followed by External ER (8.10 ± 3.11), Social Influence (5.88 ± 5.37), and Sensation Seeking (3.44 ± 2.98). The mean Craving (C) score was 14.06 ± 7.51. The mean value of the B-SCS score was 19.54 ± 5.24. It was found that the B-SCS score is significantly related to Internal ER (r = 0.441, p < 0.001) and Craving (r = 0.297, p = 0.036). The multivariable model shows that internal ER function and participants’ age are significantly related to the B-SCS score. Conclusion: Despite the limitations of the study, it is emphasized that cognitions occurring across the fluid suicidal belief system alone do not fully capture the complexity of suicide, but assessing the suicidal belief system in NSSI inpatient adolescents could nevertheless provide helpful information for identifying individuals who may have an elevated vulnerability to experiencing suicidal ideas and behaviors over time.
Spontaneous Remission of Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report
Authors: Castaño-Bonilla Tamara , Mata Raquel , Láinez-González Daniel , Gonzalo Raquel , Castañón Susana , Díaz de la Pinta Francisco Javier , Blas Carlos , López-Lorenzo José L. , Alonso-Domínguez Juan Manuel
Published: May 2024

Spontaneous remissions (SRs) in blastic plasmacytoid dendritic cell neoplasms (BPDCNs) are infrequent, poorly documented, and transient. We report a 40-year-old man presenting with bycitopenia and soft tissue infection. The bone marrow exhibited 3% abnormal cells. Immunophenotyping of these cells revealed the antigens CD45+ (dim), CD34+, CD117+, CD123+ (bright), HLA-DR+ (bimodal), CD56+ (bright), CD33+, CD13+, CD2+, and CD22+ (dim) and the partial expression of the CD10+, CD36+, and CD7+ antigens. All other myeloid, monocytic, and lymphoid antigens were negative. Genetic studies showed a complex karyotype and mutations in the TP53R337C and KRASG12D genes. On hospital admission, the patient showed a subcutaneous nodule on the right hand and left lower limb. Flow cytometry multiparameter (FCM) analysis showed the presence of 29% abnormal cells with the previously described immunophenotype. The patient was diagnosed with BPDCN. The patient was treated with broad-spectrum antibiotics for soft tissue infection, which delayed therapy for BPDCN. No steroids or chemotherapeutic or hypomethylating agents were administered. His blood cell counts improved and skin lesions disappeared, until the patient relapsed five months after achieving spontaneous remission. About 60% of abnormal cells were identified. No changes in immunophenotype or the results of genetic studies were observed. The patient underwent a HyperCVAD chemotherapy regimen for six cycles. Consolidation therapy was performed via allogeneic bone marrow transplantation with an HLA-unrelated donor. One year after the bone marrow transplant, the patient died due to the progression of his underlying disease, coinciding with a respiratory infection caused by SARS-CoV-2. In the available literature, SRs are often linked to infections or other stimulators of the immune system, suggesting that powerful immune activation could play a role in controlling the leukemic clone. Nevertheless, the underlying mechanism of this phenomenon is not clearly understood. We hypothesize that the immune system would force the leukemic stem cell (LSC) to undergo a state of quiescence. This loss of replication causes the LSC progeny to die off, resulting in the SR of BPDCN.
Research on Single-Event Burnout Reinforcement Structure of SiC MOSFET
Authors: Liao Qiulan , Liu Hongxia
Published: May 2024

In this paper, the single-event burnout (SEB) and reinforcement structure of 1200 V SiC MOSFET (SG-SBD-MOSFET) with split gate and Schottky barrier diode (SBD) embedded were studied. The device structure was established using Sentaurus TCAD, and the transient current changes of single-event effect (SEE), SEB threshold voltage, as well as the regularity of electric field peak distribution transfer were studied when heavy ions were incident from different regions of the device. Based on SEE analysis of the new structural device, two reinforcement structure designs for SEB resistance were studied, namely the expansion of the P+ body contact area and the design of a multi-layer N-type interval buffer layer. Firstly, two reinforcement schemes for SEB were analyzed separately, and then comprehensive design and analysis were carried out. The results showed that the SEB threshold voltage of heavy ions incident from the N+ source region was increased by 16% when using the P+ body contact area extension alone; when the device is reinforced with a multi-layer N-type interval buffer layer alone, the SEB threshold voltage increases by 29%; the comprehensive use of the P+ body contact area expansion and a multi-layer N-type interval buffer layer reinforcement increased the SEB threshold voltage by 33%. Overall, the breakdown voltage of the reinforced device decreased from 1632.935 V to 1403.135 V, which can be seen as reducing the remaining redundant voltage to 17%. The device’s performance was not significantly affected.
User-Centered Evaluation Framework to Support the Interaction Design for Augmented Reality Applications
Authors: Picardi Andrea , Caruso Giandomenico
Published: May 2024

The advancement of Augmented Reality (AR) technology has been remarkable, enabling the augmentation of user perception with timely information. This progress holds great promise in the field of interaction design. However, the mere advancement of technology is not enough to ensure widespread adoption. The user dimension has been somewhat overlooked in AR research due to a lack of attention to user motivations, needs, usability, and perceived value. The critical aspects of AR technology tend to be overshadowed by the technology itself. To ensure appropriate future assessments, it is necessary to thoroughly examine and categorize all the methods used for AR technology validation. By identifying and classifying these evaluation methods, researchers and practitioners will be better equipped to develop and validate new AR techniques and applications. Therefore, comprehensive and systematic evaluations are critical to the advancement and sustainability of AR technology. This paper presents a theoretical framework derived from a cluster analysis of the most efficient evaluation methods for AR extracted from 399 papers. Evaluation methods were clustered according to the application domains and the human–computer interaction aspects to be investigated. This framework should facilitate rapid development cycles prioritizing user requirements, ultimately leading to groundbreaking interaction methods accessible to a broader audience beyond research and development centers.
Impact of Diet and Nutrition in Patients with Acne Vulgaris
Authors: Ryguła Izabella , Pikiewicz Wojciech , Kaminiów Konrad
Published: May 2024

Acne vulgaris is a widespread a chronic inflammatory dermatosis that affects millions of people around the world, which has a significant influence on patients’ standard of living. The progression of this dermatosis results in the appearance of inflammatory and non-inflammatory changes, and, in severe cases, disfiguring scars and hyperpigmentation. The aetiopathogenesis of acne is complex. It involves a complex interaction of many different factors, both endo- and exogenous in their effect on the hair and sebaceous unit. Genetic predisposition, hormones, the skin and gut microbiome, psychological stress, air pollutants, aggressive facial products, and certain medications are cited as factors influencing acne formation. The link between nutrition and acne is extensively debated for many years and is still relatively controversial. Diet is commonly recognised to have a direct relationship with certain biochemical markers and the transcription of genes related to sebaceous gland function, and the proliferation of bacteria and inflammation that encourage the progression of the disease. In this review, the authors take a closer look at the existing scientific reports on the involvement of nutrition in the development of acne vulgaris.
Effect of Intermittent vs. Continuous Energy Restriction on Visceral Fat: Protocol for The Healthy Diet and Lifestyle Study 2 (HDLS2)
Authors: Lewis Michelle Y. , Yonemori Kim , Ross Alison , Wilkens Lynne R. , Shepherd John , Cassel Kevin , Stenger Andrew , Rettenmeier Christoph , Lim Unhee , Boushey Carol , Le Marchand Loïc
Published: May 2024

Obesity in the United States and Western countries represents a major health challenge associated with an increased risk of metabolic diseases, including cardiovascular disease, hypertension, diabetes, and certain cancers. Our past work revealed a more pronounced obesity–cancer link in certain ethnic groups, motivating us to develop a tailored dietary intervention called the Healthy Diet and Lifestyle 2 (HDLS2). The study protocol is described herein for this randomized six-month trial examining the effects of intermittent energy restriction (5:2 Diet) plus the Mediterranean dietary pattern (IER + MED) on visceral adipose tissue (VAT), liver fat, and metabolic biomarkers, compared to a standard MED with daily energy restriction (DER + MED), in a diverse participant group. Using MRI and DXA scans for body composition analysis, as well as metabolic profiling, this research aims to contribute to nutritional guidelines and strategies for visceral obesity reduction. The potential benefits of IER + MED, particularly regarding VAT reduction and metabolic health improvement, could be pivotal in mitigating the obesity epidemic and its metabolic sequelae. The ongoing study will provide essential insights into the efficacy of these energy restriction approaches across varied racial/ethnic backgrounds, addressing an urgent need in nutrition and metabolic health research. Registered Trial, National Institutes of Health, ClinicalTrials.gov (NCT05132686).
Do Precision and Personalised Nutrition Interventions Improve Risk Factors in Adults with Prediabetes or Metabolic Syndrome? A Systematic Review of Randomised Controlled Trials
Authors: Robertson Seaton , Clarke Erin D. , Gómez-Martín María , Cross Victoria , Collins Clare E. , Stanford Jordan
Published: May 2024

This review aimed to synthesise existing literature on the efficacy of personalised or precision nutrition (PPN) interventions, including medical nutrition therapy (MNT), in improving outcomes related to glycaemic control (HbA1c, post-prandial glucose [PPG], and fasting blood glucose), anthropometry (weight, BMI, and waist circumference [WC]), blood lipids, blood pressure (BP), and dietary intake among adults with prediabetes or metabolic syndrome (MetS). Six databases were systematically searched (Scopus, Medline, Embase, CINAHL, PsycINFO, and Cochrane) for randomised controlled trials (RCTs) published from January 2000 to 16 April 2023. The Academy of Nutrition and Dietetics Quality Criteria were used to assess the risk of bias. Seven RCTs (n = 873), comprising five PPN and two MNT interventions, lasting 3–24 months were included. Consistent and significant improvements favouring PPN and MNT interventions were reported across studies that examined outcomes like HbA1c, PPG, and waist circumference. Results for other measures, including fasting blood glucose, HOMA-IR, blood lipids, BP, and diet, were inconsistent. Longer, more frequent interventions yielded greater improvements, especially for HbA1c and WC. However, more research in studies with larger sample sizes and standardised PPN definitions is needed. Future studies should also investigate combining MNT with contemporary PPN factors, including genetic, epigenetic, metabolomic, and metagenomic data.
Temporary Employment Is Associated with Poor Dietary Quality in Middle-Aged Workers in Korea: A Nationwide Study Based on the Korean Healthy Eating Index, 2013–2021
Authors: Baek Seong-Uk , Lim Myeong-Hun , Lee Yu-Min , Won Jong-Uk , Yoon Jin-Ha
Published: May 2024

Temporary employment is associated with an elevated risk of cardiovascular diseases and mortality. This study explored the association between temporary employment and dietary quality in middle-aged workers. This cross-sectional study included a nationwide sample of middle-aged Korean workers (n = 6467). Employment type was categorized into regular, fixed-term, and daily employment, based on labor contract duration. Dietary quality was assessed using the Korean Health Eating Index (KHEI), which ranges from 0 to 100, with higher scores indicating superior dietary quality. Linear regression was used to estimate beta coefficients (β) and 95% confidence intervals (CI). The survey-weighted proportion of regular, fixed-term, and daily employment was 79.0%, 14.2%, and 6.8%, respectively. Fixed-term and daily employment were associated with a reduced KHEI compared with regular employment (β [95% CI]: −1.07 [−2.11, −0.04] for fixed-term and −2.46 [−3.89, −1.03] for daily employment). In sex-stratified analysis, the association between temporary employment and dietary quality was more pronounced in men (β [95% CI]: −1.69 [−3.71, 0.33] for fixed-term and −2.60 [−4.63, −0.53] for daily employment than in women. In conclusion, this study suggests that temporary employment is a social determinant of dietary quality in middle-aged workers.
Patchouli Alcohol Protects the Heart against Diabetes-Related Cardiomyopathy through the JAK2/STAT3 Signaling Pathway
Authors: Ji Lijun , Lou Shuaijie , Fang Yi , Wang Xu , Zhu Weiwei , Liang Guang , Lee Kwangyoul , Luo Wu , Zhuang Zaishou
Published: May 2024

Diabetic cardiomyopathy (DCM) represents a common pathological state brought about by diabetes mellitus (DM). Patchouli alcohol (PatA) is known for its diverse advantageous effects, notably its anti-inflammatory properties and protective role against metabolic disorders. Despite this, the influence of PatA on DCM remains relatively unexplored. To explore the effect of PatA on diabetes-induced cardiac injury and dysfunction in mice, streptozotocin (STZ) was used to mimic type 1 diabetes in mice. Serological markers and echocardiography show that PatA treatment protects the heart against cardiomyopathy by controlling myocardial fibrosis but not by reducing hyperglycemia in diabetic mice. Discovery Studio 2017 software was used to perform reverse target screening of PatA, and we found that JAK2 may be a potential target of PatA. RNA-seq analysis of heart tissues revealed that PatA activity in the myocardium was primarily associated with the inflammatory fibrosis through the Janus tyrosine kinase 2 (JAK2)/signal transducer and activator of the transcription 3 (STAT3) pathway. In vitro, we also found that PatA alleviates high glucose (HG) + palmitic acid (PA)-induced fibrotic and inflammatory responses via inhibiting the JAK2/STAT3 signaling pathway in H9C2 cells. Our findings illustrate that PatA mitigates the effects of HG + PA- or STZ-induced cardiomyopathy by acting on the JAK2/STAT3 signaling pathway. These insights indicate that PatA could potentially serve as a therapeutic agent for DCM treatment.
Application of Polymeric Micelles for Drug and Gene Delivery
Authors: Haladjova Emi , Rangelov Stanislav
Published: May 2024

Polymeric micelles have been extensively studied because of their ability to transfer biologically active agents, such as drugs and nucleic acids [...]
Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters
Authors: Kulkarni Chetan P. , Yang Jia , Koleske Megan L. , Lara Giovanni , Alam Khondoker , Raw Andre , Rege Bhagwant , Zhao Liang , Lu Dongmei , Zhang Lei , Yu Lawrence X. , Lionberger Robert A. , Giacomini Kathleen M. , Kroetz Deanna L. , Yee Sook Wah
Published: May 2024

The presence of mutagenic and carcinogenic N-nitrosamine impurities in medicinal products poses a safety risk. While incorporating antioxidants in formulations is a potential mitigation strategy, concerns arise regarding their interference with drug absorption by inhibiting intestinal drug transporters. Our study screened thirty antioxidants for inhibitory effects on key intestinal transporters—OATP2B1, P-gp, and BCRP in HEK-293 cells (OATP2B1) or membrane vesicles (P-gp, BCRP) using 3H-estrone sulfate, 3H-N-methyl quinidine, and 3H-CCK8 as substrates, respectively. The screen identified that butylated hydroxyanisole (BHA) and carnosic acid inhibited all three transporters (OATP2B1, P-gp, and BCRP), while ascorbyl palmitate (AP) inhibited OATP2B1 by more than 50%. BHA had IC50 values of 71 ± 20 µM, 206 ± 14 µM, and 182 ± 49 µM for OATP2B1, BCRP, and P-gp, respectively. AP exhibited IC50 values of 23 ± 10 µM for OATP2B1. The potency of AP and BHA was tested with valsartan, an OATP2B1 substrate, and revealed IC50 values of 26 ± 17 µM and 19 ± 11 µM, respectively, in HEK-293-OATP2B1 cells. Comparing IC50 values of AP and BHA with estimated intestinal concentrations suggests an unlikely inhibition of intestinal transporters at clinical concentrations of drugs formulated with antioxidants.
Conflicts and Proposals for an Antispeciesist Ecofeminist Consideration of Nonhuman Animals in Disaster Contexts
Authors: Briones Marrero Amanda
Published: May 2024

This essay aims to defend the need to help animals in any disaster situation, be it anthropogenic, natural, or hybrid. To this end, I will first establish a brief foundation of the antispeciesist principles that have been advocated by different theorists over the last decades. Then, I will describe the conflict between environmental and animal approaches as a problem for the consideration of animals in unfavorable situations. This will be followed by the ways in which animals can be harmed in such contexts. After that, I will argue that many anthropogenic disasters affect animals, but they also deserve aid in the face of natural disasters: they are sentient beings and capable of suffering just like humans, to whom help is offered unconditionally in such cases. Finally, I will propose sentience, particularly suffering, and an ecofeminist and antispeciesist approach to address the situation of animals in disaster situations in a dialogic way between environmentalist and individual-centered positions.
Penrose Scattering in Quantum Vacuum
Authors: Mendonça José Tito
Published: May 2024

This paper considers the scattering of a probe laser pulse by an intense light spring in a QED vacuum. This new scattering configuration can be seen as the vacuum equivalent to the process originally associated with the scattering of light by a rotating black hole, which is usually called Penrose superradiance. Here, the rotating object is an intense laser beam containing two different components of orbital angular momentum. Due to these two components having slightly different frequencies, the energy profile of the intense laser beam rotates with an angular velocity that depends on the frequency difference. The nonlinear properties of a quantum vacuum are described by a first-order Euler–Heisenberg Lagrangian. It is shown that in such a configuration, nonlinear photon–photon coupling leads to scattered radiation with frequency shift and angular dispersion. These two distinct properties, of frequency and propagation direction, could eventually be favorable for possible experimental observations. In principle, this new scattering configuration can also be reproduced in a nonlinear optical medium.