bluuebunny/crossref_metadata_2025 huggingface dataset:
The Dual Function of the Polybasic Juxtamembrane Region of Syntaxin 1A in Clamping Spontaneous Release and Stimulating Ca2+-Triggered Release in Neuroendocrine Cells
Authors: Singer-Lahat Dafna , Barak-Broner Noa , Sheinin Anton , Greitzer-Antes Dafna , Michaelevski Izhak , Lotan Ilana
Published: November 2017

The exact function of the polybasic juxtamembrane region (5RK) of the plasma membrane neuronal SNARE, syntaxin 1A (Syx), in vesicle exocytosis, although widely studied, is currently not clear. Here, we addressed the role of 5RK in Ca2+-triggered release, using our Syx-based intramolecular fluorescence resonance energy transfer (FRET) probe, which previously allowed us to resolve a depolarization-induced Ca2+-dependent close-to-open transition (CDO) of Syx that occurs concomitant with evoked release, both in PC12 cells and hippocampal neurons and was abolished upon charge neutralization of 5RK. First, using dynamic FRET analysis in PC12 cells, we show that CDO occurs following assembly of SNARE complexes that include the vesicular SNARE, synaptobrevin 2, and that the participation of 5RK in CDO goes beyond its participation in the final zippering of the complex, because mutations of residues adjacent to 5RK, believed to be crucial for final zippering, do not abolish this transition. In addition, we show that CDO is contingent on membrane phosphatidylinositol 4,5-bisphosphate (PIP2), which is fundamental for maintaining regulated exocytosis, as depletion of membranal PIP2 abolishes CDO. Prompted by these results, which underscore a potentially significant role of 5RK in exocytosis, we next amperometrically analyzed catecholamine release from PC12 cells, revealing that charge neutralization of 5RK promotes spontaneous and inhibits Ca2+-triggered release events. Namely, 5RK acts as a fusion clamp, making release dependent on stimulation by Ca2+.

SIGNIFICANCE STATEMENTSyntaxin 1A (Syx) is a central protein component of the SNARE complex, which underlies neurotransmitter release. Although widely studied in relation to its participation in SNARE complex formation and its interaction with phosphoinositides, the function of Syx's polybasic juxtamembrane region (5RK) remains unclear. Previously, we showed that a conformational transition of Syx, related to calcium-triggered release, reported by a Syx-based FRET probe, is abolished upon charge neutralization of 5RK (5RK/A). Here we show that this conformational transition is dependent on phosphatidylinositol 4,5-bisphosphate (PIP2) and is related to SNARE complex formation. Subsequently, we show that the 5RK/A mutation enhances spontaneous release and inhibits calcium-triggered release in neuroendocrine cells, indicating a previously unrecognized role of 5RK in neurotransmitter release.
Utjecaj interne komunikacije na zadovoljstvo zaposlenika radnim mjestom
Authors: Bolfek Berislav , Milković Viktorija , Lukovac Marko
Published: November 2017

Komunikacija je osnovni element socijalizacije svakog pojedinca i ima ključnu ulogu u stvaranju odnosa s obitelji, prijateljima, suradnicima i poslovnim partnerima. Komunikacija je proces svakodnevno prisutan u privatnom i poslovnom svijetu. Komuniciranje je proces sporazumijevanja, prijenosa informacija, stvaranja novih znanja i ideja te je jedan od osnovnih preduvjeta bez kojeg se nema uspješnog poslovanja. Interna komunikacija je proces razmjene informacija, ideja, misli i planova među ljudima unutar organizacije. Učinkovita interna komunikacija pridonosi uspostavi dobrih odnosa u organizaciji i poboljšanju općeg stanja unutar organizacije. Interna komunikacija jedan je od najvažnijih čimbenika koji utječe na zadovoljstvo zaposlenika, a time se to zadovoljstvo reflektira na produktivnost zaposlenika i utječe na uspjeh poslovanja. U ovom radu provedeno je istraživanje kako bi se utvrdila razina zadovoljstva poslom i internom komunikacijom djelatnika trgovačkog društva zastupništva i distribucije medicinske opreme.
Dom Feliciano na instalação da igreja do Rio Grande do Sul
Authors: Hastenteufel Zeno
Published: November 2017

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A constituição da rede urbana brasileira nos quadros da formação do mundo ocidental moderno
Authors: Freitas Prez Léa
Published: November 2017

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POR UMA REVISÃO DAS HIPÓTESES SOBRE OS CENTROS DE ORIGEM E ROTAS E EXPANSÃO PRÉ-HISTÓRICAS DOS TUPIS
Authors: S. Noelli Francisco
Published: November 2017

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ARQUEOLOGIA PRÉ-HISTÓRICA DO URUGUAI: UMA REVISÃO
Authors: Hilbert Klaus
Published: November 2017

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UM MESTRE: JOÃO JOSÉ PLANELLA
Authors: Santoro de Constantino Núncia
Published: November 2017

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Религиозно­-церковная политика советского режима в отношении Польской автокефальной православной церкви на Волыни в 1939–1941 гг.
Authors: Гордиенко Вячеслав , Гордиенко Галина
Published: November 2017

В статье раскрывается содержание советской религиозно­‑церковной политики в первый период Второй мировой войны на оккупированных польских землях. Показаны условия жизнедеятельности части Польской автокефальной православной церкви (ПАПЦ), которая оказалась на советской территории. Акцентировано внимание на противоречиях в отношениях советского атеистического режима к православным в Западной Украине и Белоруссии. Изложены факты, которые опровергают концепцию «либерализации» религиозной политики советского партийно­‑государственного руководства в 1939–1941 гг. Анализируется активность Московского патриархата, направленную на переподчинение православных приходов ПАПЦ в Западной Украине и Белоруссии под юрисдикцию РПЦ. В статье доказывается, что инициатором деятельности Московского патриархата по ликвидации автокефалии Польской православной церкви на оккупированных землях были советские спецслужбы. Показано, что мероприятия по переподчинению православных приходов бывшей Польской православной церкви Московскому патриархату осуществлялись под контролем и опекою органов НКВД. Обосновывается вывод о том, что наличие в Западной Украине и Белоруссии полноценной, функциональной, численной и автокефальной православной конфессии вынудило советский режим к взаимодействию с Московским патриархатом. Доказывается, что вновьприобретенный опыт был потом использован партийно­‑государственным руководством СССР в Прибалтике и в годы немецко­‑советской войны.
MODERN APPROACHES TO DYSPHOTOPSIA ANALYSIS, ASSESSMENTOF PATIENT SATISFACTION AND SPECTACLE INDEPENDENCE AFTER MULTIFOCALINTRAOCULAR CORRECTION: REVIEW
Authors: Morozova T. A. , Kerimov T. Z.
Published: November 2017

The core target of multifocal IOLs implantation is to provide advanced visual quality at different distances without spectacle or contact lenses that can be valuable when monofocal IOLs are implanted. Patients with monofocal IOLs need spectacles or contact lenses for the near and intermediate distance's vision. Multifocal intraocular lenses due to the optical part construction provide spectacle independence for patients in the postoperative period. The aim of this review was to analyze the modern approach to the several aspects of multifocal intraocular correction: spectacle independence, dysphotopsia, patient satisfaction. Patients’ questionnaire after surgery provides the data for evaluation of the quality of life, vision satisfaction at all range of distances on different levels of illumination, and patient activities of daily living. During the long period, a photic phenomenon (dysphotopsia) had been discussed in the literature as the principal reason for decrease of patients satisfaction with the treatment and lens explantation. Recently, high grade of spectacle independence and low risk of photic phenomena after modern multifocal IOLs implantation determine high-level patient satisfaction after cataract surgery. Multifocal intraocular correction is the effective technology for restoring passive accommodation that the wide range of the clinical studies proved. This review analyzes 33 studies (32 clinical studies and 1 metaanalisis) published in international peer-reviewed targeted titles.
Human Parechovirus A conventional nested genotyping RT-PCR ["Harvala assay"; 2008-2015] v4
Authors: M Mackay Ian , Y. T. Wang Claire
Published: November 2017

I and my team used this assaybetween 2008-2015; we dubbed it the "Harvala assay". It produces an amplicon that includes the 3' end of VP3 and the 5' end of VP1, spanning the junction. In silicosequence alignments indicated the highly degenerate olignucleotides could theoretically detect af least HPeV 1-7, 17 and 18.
The Impact of Prenatal Yoga on Exercise Attitudes and Behavior: Teachable moments from a Randomized Controlled Trial
Authors: Babbar Shilpa , Porter Blake W. , Williams Karen B.
Published: November 2017

Objective: Pregnancy serves as an opportune time for “teachable moments” to elicit positive behavior change. We evaluated change in exercise perception, behavior and gestational weight gain in participants engaged in a one-hour educational experience.

Methods: Women between 28 0/7 to 36 6/7 weeks with no prior yoga experience carrying a non-anomalous singleton fetus participated in a randomized controlled trial on prenatal yoga. The yoga group engaged in a one-hour yoga class; the attention control educational group, in a one-hour presentation on exercise, nutrition and obesity in pregnancy. Maternal perception of yoga, exercise effects and current health status was conducted before and after the intervention. Gestational weight gain (GWG) and body mass index (BMI) were assessed. A postpartum survey was performed to determine self-reported behavioral changes during and after pregnancy.

Results: Over 6 months, 52 women were randomized and 46 (88%) completed the study. Women reported a more positive attitude towards exercise and yoga after the yoga intervention. Total GWG was similar (yoga 32.9 versus education 32.8 pounds, p = 0.98). Stratified by pre-pregnancy BMI, 13% gained within and 61% gained above the Institute of Medicine guidelines in each group. Of 29 inactive women prior to the intervention, 60% of the yoga group and 75% of the education group began prenatal exercises after the intervention and 50% of each group continued to exercise after delivery. There were no significant differences between groups.

Conclusion: A one-time, one-hour intervention teaching a new exercise or educating women during pregnancy can positively impact pregnancy behaviors and perception with the potential to improve maternal and neonatal outcomes.

Clinical Trial Registration: Clinicaltrials.gov, www.clinicaltrials.gov, NCT02063711.
Yoga practice is associated with superior motor imagery performance
Authors: Hartnoll Susannah H , Punt T David
Published: November 2017

Yoga is an activity that aims to integrate physical, mental and spiritual elements and is an increasingly popular approach to enhancing physical fitness. The integration of imagery within yoga practice is considered an important component and may be critical in contributing to the benefits of yoga that have been reported. In this study, we tested whether individuals who practice yoga demonstrate superior performance on an objective measure of implicit motor imagery. Thirty-six participants (18 yoga, 18 non-yoga) matched for age, sex and handedness, undertook the hand laterality recognition task; an objective measure of implicit motor imagery performance. Accuracy and response times were gathered and analysed to determine any group differences as well as any differences relating to the typical hallmarks of imagery (i.e. dominance and awkwardness effects) on the task. Response Times (RTs) in the yoga group were significantly faster than controls (p < 0.05) and there was also a trend towards greater accuracy for the Yoga group (p = 0.073). Dominance effects (faster responses to images corresponding with the dominant limb) and Awkwardness effects (faster responses to images corresponding with natural compared with awkward postures) were evident across groups, supporting the participants' use of motor imagery in undertaking the task. Additionally, a Group × Awkwardness interaction (p < 0.05) revealed that the enhanced imagery performance for the yoga group was most pronounced for awkward postures. This is the first study to show that yoga practice is associated with superior motor imagery performance; an association that may be important in explaining the established rehabilitative value of yoga for chronic pain.
Guidelines for teaching yoga to women with breast cancer-related lymphoedema: an evidence-based approach
Authors: Loudon Annette , Barnett Tony , Williams Andrew D. , Visentin Denis , Immink Maarten A. , Piller Neil
Published: November 2017

Breast cancer-related lymphoedema (BCRL) is a chronic condition that requires lifelong management to prevent the condition worsening and to reduce the threat of infection. Women are affected in all domains of their life. As a holistic practice, yoga may be of benefit by reducing both the physical and psychosocial effects of lymphoedema. Women with BCRL are attending yoga classes in increasing numbers, so it is essential that yoga be based on principles that ensure lymphoedema is controlled and not exacerbated. Two Randomised Controlled Trials with a yoga intervention have had positive results after an 8-week intervention (n=28) and 6-months after a 4-week intervention (n=18). The first study had several significant results and women reported increased biopsychosocial improvements. Both studies showed trends to improved lymphoedema status. The yoga interventions compromised breathing, physical postures, meditation and relaxation practices based on Satyananda Yoga®, with modifications to promote lymphatic drainage and following principles of best current care for those with BCRL. Individual needs were considered. The yoga protocol that was used in the 8-week trial is presented. Our aim is to provide principles for yoga teachers/therapists working with this clientele that can be adapted to other yoga styles. Further, these principles may provide a basis for the development of yoga programs for people with secondary lymphoedema in other areas of their body as the population requiring cancer treatment continues to increase. Whilst the style of yoga presented here has had positive outcomes, further application and research is needed to fully demonstrate its effectiveness.
A study on correlation between allergen and allergic contact dermatitis
Authors: Nagure Ashok Kumar B. , Kalyanrao Y. Guruprasad
Published: November 2017

Background: Agents which cause contact dermatitis are simple chemical compounds and by themselves these agents will not cause sensitization and are called haptens. These require another molecule usually a protein called the carrier molecule derived from the epidermis to cause allergic sensitization. The confirmation of contact dermatitis is done by the patch testing. There is no substitute for the patch test in the management of allergic contact dermatitis.

Methods: After selecting the patient suspected to have allergic contact dermatitis the findings were recorded in the proforma which also includes the systemic examination of CVS, CNS, GIT and respiratory system to study systemic correlation if any. Investigation were done which included Hb%, TLC, DLC, urine routine and microscopic examination, patch testing and other special investigations if required. The patient was subjected to patch testing after the acute stage has subsided and the patient was on no therapy with topical or systemic steroids prior to patch testing.

Results: The incidence of allergic contact dermatitis due to cosmetics was found in 7 (5.6%) cases. In that hair dye (PPD) inducing dermatitis was found in 4 (57.4%) and due to hair oil 1 (14.2%), kumkum 1 (14.2%) and Sunsilk shampoo 1 (14.2%). The incidence of PPD sensitivity in this series of 125 cases was 4 (3.2%).

Conclusions: PPD is a well-known potent sensitizer, it is a chief constituent of the commonly used hair dyes and also some other cosmetics like nail polish.
Lesión pulmonar aguda tras transfusión de concentrado de hematíes en el paciente pediátrico. Presentación de caso y revisión de la literatura
Authors: Pérez-Caballero-Macarrón César , Moreno- Jiménez Gemma , Coca-Pérez Ana , Vázquez-Martínez José Luis , Tenorio-Núñez María , Stanescu Sintziana , Tapia-Moreno Rocío , Jiménez-Martín Ana
Published: November 2017

La lesión pulmonar aguda (LPA) relacionada con la transfusión TRALI (transfusion related acute lung injury) se define como una lesión pulmonar que se desarrolla durante o dentro de las primeras seis horas post-transfusionales, con una PaO2/FiO2 igual o menor de 300 mmHg, en ausencia de edema pulmonar cardiogénico, o de otro factor de riesgo de LPA. Es una complicación subestimada en niños enfermos críticamente debido a que se asocia los síntomas a la enfermedad de base, siendo la causa principal de muerte relacionada con la transfusión. Presentamos un caso de TRALI grave en un niño durante la transfusión de un concentrado de hematíes, procedente de una donadora multípara, en una Unidad de Cuidados Intensivos Pediátricos, con resultado favorable. El tratamiento es de soporte en función de la gravedad del cuadro clínico y la prevención se centra en tres estrategias: selección de donantes, actuación sobre el almacenamiento de los productos hemáticos y evitar las transfusiones innecesarias. Es importante incluir casos pediátricos de TRALI en la literatura médica para avanzar en la comprensión de esta complicación transfusional en los niños.
Leucemias neonatales: experiencia en el Hospital Infantil de México Federico Gómez (HIMFG)
Authors: Ibarra-Ríos Daniel , Zapata-Tarres Marta , Villanueva-García Dina , Peña-del Castillo, Humberto , Dorantes-Acosta Elisa María , Juárez-Villegas Luis Enrique
Published: November 2017

INTRODUCCIÓN: la leucemia neonatal (o congénita) es aquella diagnosticada en los primeros 30 días tras el nacimiento. Su incidencia se reporta en 1 a 5 por cada millón de recién nacidos vivos (corresponde a menos del 1% de las leucemias en pediatría).OBJETIVO: describir los casos diagnosticados en el Hospital Infantil de México Federico Gómez (HIMFG).PRESENTACIÓN DE LA SERIE DE CASOS: se incluyó pacientes menores de 30 días a los cuales se les realizó el diagnóstico morfológico de leucemias entre el 1º de enero de 1990 y el 1º de junio del 2012 en el HIMFG.RESULTADOS: en los 12 años del estudio se identificaron 3,061 casos de leucemias, de los cuales sólo cinco expedientes correspondieron a leucemias neonatales. Se describen tres pacientes femeninos y dos masculinos, con edad media al diagnóstico de 21 días (17-26 días), tratándose con mayor frecuencia de leucemia mieloide (LMA) en tres casos (60%) y leucemia linfoide en dos pacientes. Un caso de LMA asociado a síndrome de Down. En ningún caso se encontraron translocaciones de riesgo. Cuatro pacientes (80%) recibieron manejo para síndrome de lisis tumoral. Cuatro pacientes fallecieron con una mediana de edad de 84 días (57-176 días). El paciente que sobrevivió recibió tratamiento con doxorrubicina y metotrexate al 50% y en suúltimo seguimiento a los tres años de edad continuaba en remisión.CONCLUSIONES: la presentación de los casos corresponde a la reportada en literatura con respecto a frecuencias de leucemias linfoides y mieloides. La supervivencia global a largo plazo fue del 20% (33% para las mieloides) con un solo paciente en remisión. Este padecimiento tiene un pronóstico fatal que puede mejorar con el diagnóstico oportuno (incluso prenatal) y manejo con quimioterapia intensiva. Ésta es la serie más grande de leucemias neonatales reportada en México.
A REVIEW STUDY OF ZINC OXIDE NANOPARTICLES SYNTHESIS FROM PLANT EXTRACTS
Authors: Lakshmi Sagili Jhansi , Bai R S Roopa , H Sharanagouda , Nidoni Uday kumar
Published: November 2017

The development of nanotechnology is making the interest of researchers towards the synthesis of nanoparticles for the bioapplication. Metal oxides such as ZnO have received increasing attention as antibacterial materials in recent years because of their stability under harsh processing conditions, and also because they are generally regarded as safe materials for human beings and animals. Zinc activates 300 enzymes, and it plays a role in many other phenomena like growth, membrane stability, bone mineralization, tissue growth, and repair, wound healing and cell signalling.

Many studies have shown that ZnO nanoparticles have enhanced antibacterial activity. Use of plant and plant materials for the synthesis of Zinc nanoparticles is relatively new and exciting research field. Various plants were used for the synthesis of nanoparticles using a green synthesis method.

Nanoparticles were synthesized from all the parts of the plant separately like stem, flower, leaf, latex, root, peel, stem bark and fruits. The prepared nanoparticles of Zinc oxide were characterized by using XRD, FTIR, UV-VIS Spectroscopy, EDAX, Particle size analyzer, TGA, and SEM.

The objective of this review was to report on the synthesis of Zinc oxide nanoparticles by using different plant extracts and their significance in different fields.
Call for Submissions: Special Issue, Cultural and Pedagogical Inquiry (CPI)
Authors: DePass Cecille
Published: November 2017

The Politics of Contemporary Education with Guest Editor: Paul A. Crutcher (University of Arkansas - Little Rock)Through scholarly and creative work, this proposed CPI Special Issue explores central aspects and impacts of the contentious politics of contemporary education. Potential contributors to this Special Issue should submit a proposal to Dr. Paul A. Crutcher (pacrutcher@ualr.edu) by December 15, 2017.  Proposals should be single Word or PDF files that include:  (a) a title of up to 150 characters, (b) an abstract of up to 150 words, and (c) a description of the proposed paper or creative work of up to 500 words.
NEOLIBERALIZAM I OBRAZOVANJE U KONTEKSTU GLOBALNE OBRAZOVNE POLITIKE
Authors: Kanić Sanela , Kovač Vesna
Published: November 2017

Pojam globalne obrazovne politike javio se u posljednjih nekoliko desetljeća, a riječ je o fenomenu koji obuhvaća obilježja obrazovnih reformi prisutnih na globalnoj razini do kojih je došlo uslijed globalizacijskih mehanizama, odnosno opisuje ih, definira i nastoji ustanoviti tko stoji iza njihove diseminacije. Uslijed globalizacije, došlo je i do tvorbe transnacionalnog obrazovnog prostora gdje su se, uz vlade, pojavili i novi akteri, čiji su utjecaji na obrazovne politike postajali sve snažniji. Najistaknutijima se smatraju međunarodne organizacije koje različitim mehanizmima utječu na vlade mnogih zemalja, prilikom čega imaju mogućnost promicanja vlastitih agenda koje karakterizira jedna zajednička točka – neoliberalna doktrina. Pojava neoliberalizma uslijed svjetske ekonomske stagnacije sedamdesetih godina prošlog stoljeća rezultirala je prisutnošću tržišnih rješenja s naglaskom na učinkovitost, konkurenciju i slobodu izbora, što se, zahvaljujući globalizaciji, trajno ukorijenilo u obrazovne sustave gotovo svih zemalja. Pojave poput decentralizacije, privatizacije, novog  javnog menadžmenta i novog profesionalizma postale su temelj za formiranje novih globalnih obrazovnih trendova, a uključenost privatnog sektora i redefinirana uloga vlade u pružanju i financiranju obrazovnih usluga smatra se svojevrsnim imperativom kada je riječ o neoliberalnim utjecajima na obrazovanje. Naposljetku, došlo je do prisutnosti javno-privatnih partnerstva, čija pojavnost uprizoruje prodor privatizacije i tržišnih mehanizama u obrazovanje.
Salivary Oxytocin Concentration Changes during a Group Drumming Intervention for Maltreated School Children
Authors: Yuhi Teruko , Kyuta Hiroaki , Mori Hisa-aki , Murakami Chihiro , Furuhara Kazumi , Okuno Mari , Takahashi Masaki , Fuji Daikei , Higashida Haruhiro
Published: November 2017

Many emotionally disturbed children who have been maltreated and are legally separated from their parents or primary caregivers live in group homes and receive compulsory education. Such institutions provide various special intervention programs. Taiko, a Japanese style of group drumming, is one such program because playing drums in a group may improve children’s emotional well-being. However, evidence for its efficacy has not been well established at the biological level. In this study, we measured salivary levels of oxytocin (OT), a neuropeptide associated with social memory and communication, in three conditions (recital, practice, and free sessions) in four classes of school-aged children. Following the sessions, OT concentrations showed changes in various degrees and directions (no change, increases, or decreases). However, the mean OT concentration changes after each session increased, ranging from 112% to 165%. Plasma OT concentrations were equally sensitive to drum playing in school-aged boys and girls. However, the difference between practice and free play sessions was only significant among elementary school boys aged 8-12 years. The results suggest that younger boys are most responsive to this type of educational music intervention.
Energy Storage Scheduling with an Advanced Battery Model: A Game–Theoretic Approach
Authors: Pilz Matthias , Al-Fagih Luluwah , Pfluegel Eckhard
Published: November 2017

Energy storage systems will play a key role for individual users in the future smart grid. They serve two purposes: (i) handling the intermittent nature of renewable energy resources for a more reliable and efficient system, and (ii) preventing the impact of blackouts on users and allowing for more independence from the grid, while saving money through load-shifting. In this paper we investigate the latter scenario by looking at a neighbourhood of 25 households whose demand is satisfied by one utility company. Assuming the users possess lithium-ion batteries, we answer the question of how each household can make the best use of their individual storage system given a real-time pricing policy. To this end, each user is modelled as a player of a non-cooperative scheduling game. The novelty of the game lies in the advanced battery model, which incorporates charging and discharging characteristics of lithium-ion batteries. The action set for each player comprises day-ahead schedules of their respective battery usage. We analyse different user behavior and are able to obtain a realistic and applicable understanding of the potential of these systems. As a result, we show the correlation between the efficiency of the battery and the outcome of the game.
The Impact of World Food Price Fluctuation towards Indonesian Macroeconomics
Authors: Ilmia Jami - , Wilantari Regina Niken , Luthfi Agus -
Published: November 2017

Stability of price is a crucial factor for export and import activities, especially food commodities. Indonesia with the characteristics of a small open economy are vulnerable to external price shock as the implication of economic globalization. Understanding the food price shock useful for designing risk mitigation to minimize the effects of shocks to macroeconomic variables. The purpose of this research is to analyze the impact of macroeconomics from Vector Auto-Regression (VAR) methods. The sensitivity of impulse response estimation and variance decomposition which outlines how large and how the effect of the food price shock. Impulse response analysis shows shocks on global food price got the response by fastest and the most powerful by inflation. While the description of variance decomposition, variation described by economic growth. The results show that the global food price affects economic growth that is transmitted through inflation.
Investment attractiveness of the port industry in crisis conditions
Authors: Ilchenko Svitlana , Glushko Ganna
Published: November 2017

Historically, the maritime industry in Ukraine, which previously was subordinated to the Ministry of Transport of Ukraine and whose successor is the Ministry of Infrastructure of Ukraine, was complex of different organizations (shipping companies, ports, ship-repairing and shipbuilding factories and other related and auxiliary enterprises). They had their own organizational structures, goals and tasks and in some way interacted with each other. Such organization was aimed, first of all, at achieving target production indicators formed by the state authorities. In fact, such structure of maritime industry can be regarded as vertically integrated. When the issue of increasing the economic efficiency of the main component of the maritime industry (of the ports) was raised, the main efforts were aimed at minimizing the costs of their functioning. This led to the creation of horizontally integrated (in whole or in part) companies in the maritime industry. The driving factor for their implementation should be the transformation of organizational and economic mechanisms of regulation of the port’s activity from the point of view of a clearly defined anti-crisis character. Therefore, the goal of the study was to develop and justify the feasibility of using a model that will determine the effectiveness of the strategy of investment into the development of the organizational and economic mechanism of regulation of the port activity. The calculations of determining the best variant of an investment project under different external conditions are presented. In calculations based on certain criteria (appropriate levels of capitalization and effective dividend policies), we took into account the factors related to the expectations of the crisis in Ukraine, Ukraine’s unpreparedness to enter the new technological phase, the loss of scientific and technical personnel, inflationary phenomena and instability of the national and world currencies. In addition, within the framework of the developed model, the authors propose an algorithm that makes it possible to select the characteristics and determine the parameters of optimization of the organizational and economic mechanism of regulation of the port activity under the conditions of long-term continuation of the crisis situation.
Evaluating the performance of the Motley Fool’s Stock Advisor™
Authors: Filbeck Greg , Lyon Alexander , Zhao Xin
Published: November 2017

Since March 2002, The Motley Fool’s founders, David Gardner and Tom Gardner, have published monthly stock recommendations under Motley Fool’s premium Stock Advisor service. In this paper, the authors investigate whether analysts’ recommendations can add value for investors by examining the performance of portfolios constructed based on Motley Fool’s recommendations. They evaluate the announcement effect on share price corresponding to the publication of stock recommendations. Additionally, the researchers examine holding period returns for a portfolio imitating the actions of Stock Advisor. They find portfolios composed of recommendations through Stock Advisor added value initially upon recommendation and across extended holding periods. Additionally, the authors find that the Stock Advisor sample outperforms other sample portfolios on a risk-adjusted basis and over several subperiods. The findings contribute to the literature on the usefulness of analysts’ recommendations in adding value to investors’ portfolios.
Kapasitas Refleksif Pemuda dalam Transisi Menuju Dunia Kerja
Authors: Sutopo Oki Rahadianto , Meiji Nanda Harda Pratama
Published: November 2017

This article tries to explain the role of reflexive capacity among young people during transition to work. Specifically, four informants in this research are representations of middle class youth from Yogyakarta. This research applies qualitative methods and in-depth interviews as techniques to gather data. This article shows the relevancy of reflexive capacity as a form of embodied cultural capital. Young people whom possess high volume of reflexive capacity will be able to understand the shift of rule of the game in the field and responds quickly and strategically. Furthermore, this reflexive capacity is important as a pre-requirement to anticipate present and future risk. On the other hand, reflexive capacity is only one of entry points among other forms of capital because in reality, young people have to actively negotiate with multilayers structural forces which objectively exist.
Harapan dan Kenyataan Penerapan “Kawasan Tanpa Rokok (KTR)” di Lingkungan Kampus Universitas Udayana Denpasar
Authors: Kamajaya Gede , Nugroho Wahyu Budi , Tamim Imron Hadi
Published: November 2017

This research attempts to examine the effectiveness of the areas without smokeables “Kawasan Tanpa Rokok”(KTR) policy in Udayana University, Denpasar which was implemented at about one year (June 2015-June 2016). Furthermore, this research aims to emphasize the rationality of the smokers which are continuing to smoke although the KTR signs was put in the Udayana University areas. To accent the private and personal rationality, the phenomenology method which focus on subjective actor (the smokers) was used in this research. This method is a qualitative method and purpose to collect the deeper data to expound the personal reasons of the smokers who always smoke continuously in KTR areas. From the result of the research, there were some problems that made the KTR policy was not effective in Udayana University areas. First, there was no clear sanction for the smokers; Second, the lecture and the university employee did not show the good instance to comply with the KTR policy; Third, a cigarette was sell openly in University store (Waserda); Fourth, there was no smoking areas for the smokers in Udayana University, Denpasar.
The Epidemiology of Adult Distal Femoral Shaft Fractures in a Central London Major Trauma Centre Over Five Years
Authors: Khan Akib Majed , Tang Quen Oat , Spicer Dominic
Published: November 2017

Background:

Distal femoral fractures account for 3-6% of adult femoral fractures and 0.4% of all fractures and are associated with significant morbidity and mortality rates. As countries develop inter-hospital trauma networks and adapt healthcare policy for an aging population there is growing importance for research within this field.

Methods:

Hospital coding and registry records at the central London Major Trauma Center identified 219 patients with distal femoral shaft fractures that occurred between December 2010 and January 2016. CT-Scans were reviewed resulting in exclusion of 73 inappropriately coded, 10 pediatric and 12 periprosthetic cases. Demographics, mechanism of injury, AO/OTA fracture classification and management were analyzed for the remaining 124 patients with 125 fractures. Mann Whitney U and Chi Squared tests were used during analyses.

Results:

The cases show bimodal distribution with younger patients being male (median age 65.6) compared to female (median age 71). Injury caused through high-energy mechanisms were more common in men (70.5%) whilst women sustained injuries mainly from low-energy mechanisms (82.7%) (p<0.0001). Majority of fractures were 33-A (52.0%) followed by 33-B (30.4%) and 33-C (17.6%). Ninety-two (73.6%) underwent operative management. The most common operation was locking plates (64.1%) followed by intramedullary nailing (19.6%).

Interpretation:

The epidemiology of a rare fracture pattern with variable degrees of complexity is described. A significant correlation between biological sex and mechanism of injury was identified. The fixation technique favored was multidirectional locking plates. Technical requirements for fixation and low prevalence of 33-C fractures warrant consideration of locating treatment at centers with high caseloads and experience.
HYPERHOMOCYSTEINEMIA LEAD TO TRANSMURAL INFLAMMATION OF COLON AND INCREASE SEVERITY OF DISEASE IN ACETIC ACID-INDUCED COLITIS IN RAT
Authors: Souad Lamda , Dalila Naimi , Cherifa Aggoun
Published: November 2017

Objective: The present study was designed to evaluate the effect of hyperhomocysteinemia (Hhcy) induced by feeding rats high methionine diet on the colon wall. Colonic damages caused by Hhcy were compared with those induced by acetic –acid induced colitis.Methods: Sprague-Dawley rats (200-250g) were divided into four groups: group C (control), group M (received 1 g/kg methionine p. o. during 15 d), group A (colitis was induced by transrectal administration of acetic acid 4% on 8th day) and group MA (received methionine and acetic acid). At the end of the study, plasma homocysteine, C-reactive protein (CRP) and leukocytes (WBC) count were evaluated, all rats were sacrificed and distal 8 cm of the colon was dissected. Colon was weighed for disease activity index (DAI) and injuries were assessed macroscopically and histologically.Results: High methionine diet induced significant (P<0.001) increase of homocysteine (hcy), CRP levels and WBC count compared to control. Acetic acid rats showed a significant decrease of WBC count. Mixed treatment caused a significant increase of hcy, CRP and a significant decrease of WBC count. Our results showed that Hhcy causes significant damages and immune cells infiltration in all layers of the colonic wall.Conclusion: The present investigation demonstrated that Hhcy increased the major inflammatory markers as CRP and leukocytes count and produced transmural colitis in rats. Effect of Hhcy is more toxic on the colonic wall than acetic acid indeed while acetic acid lesions are localized in mucosa and submucosa the lesions of hcy extend to the all layers (mucosa, submucosa and muscularis propria). Acetic acid induced colitis in hyperhomocysteinemic rats increased the severity of colitis.
GC-MS PROFILE OF IN VIVO AND IN VITRO SHOOTS OF CLEOME GYNANDRA L.
Authors: P. Karthikeyan A. V. , I. Sudan
Published: November 2017

Objective: Investigation of the bioactive compounds from the ethanol shoot extracts of in vivo and in vitro plants of Cleome gynandra (C. gynandra) through GC-MS analysis. Methods: The nodal explants were cultured on Murashige and Skoog (MS) medium supplemented with different concentrations of 6-benzyl-aminopurine (BAP), kinetin-6-furfurylaminopurine (Kin) and indole 3 acetic acids (IAA) for shoot induction. In the present study, the phytochemical constituents were analyzed from the ethanol extract of in vivo and in vitro plants of C. gynandra using Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The mass spectrum of the ethanol extract was compared with the available library sources.Results: In the present study, different concentrations of cytokinins and in the combination of IAA are used to develop regenerated shoots. The maximum number of shoots was obtained 9.2±0.41 with the length of 6.6 cm and highest frequency of (100%) shoot induction was observed on MS medium containing 10 μM BAP with 4 μM IAA. The GC-MS analysis revealed that the shoots of in vivo and in vitro plants contained 21phytochemicals, of these 3 components were similar in both in vivo and in vitro plants, 2 phytochemical's are repeated with different RT, 7 components are having biological activity and in the remaining 9 components, biological activities are not reported.Conclusion: The present study, the in vitro regeneration, combinations of hormones (10 μM BAP plus 4 μM IAA) tested showed the best result than individual and also revealed that the synthesis of more number of phytochemicals present in the ethanolic extracts of in vitro plants than the in vivo plants of C. gynandra.
PHYCHEMISTRY, PHYTOCHEMICAL, PHARMACOLOGICAL AND MOLECULAR STUDY OF ZINGIBER OFFICINALE ROSCOE: A REVIEW
Authors: Ashraf Kamran , Sultan Sadia , Shah Sayed Adnan Ali
Published: November 2017

The rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, is one of the most widely used spice and condiment. It is also an integral part of many traditional medicines and has been extensively used in Chinese, Ayurvedic, Tibb-Unani, Srilankan, Arabic, and African traditional medicines, since antiquity, for many unrelated human ailments including common colds, fever, sore throats, vomiting, motion sickness, gastrointestinal complications, indigestion, constipation,  gastritis, epigastric discomfort, gastric ulcerations, indigestion, nausea  vomiting etc. and scientific studies have validated the ethnomedicinal uses. The chemistry, phytochemical, pharmacological and molecular studies of Z. officinale is reviewed. This review was compiled to provide consolidated information covering different aspects of the plant, to provide a basis on which to plan future studies and to promote sustainable use of Z. officinale.
DEVELOPMENT OF NEW PYRAZOLE HYBRIDS AS ANTITUBERCULAR AGENTS: SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDY
Authors: Shaikh Sameer I. , Zaheer Zahid , Mokale Santosh N. , Lokwani Deepak K.
Published: November 2017

Objective: synthesis of new 1, 3-diphenyl pyrazole derivatives 9(a-f) and 10(a-f) using molecular hybridization approach for antitubercular and cytotoxic studies.Methods: The structures of synthesized compounds were confirmed by 1H-NMR, 13C-NMR and mass spectra’s. The antitubercular activity of compounds and standard drugs were assessed against Mycobacterium tuberculosis using microplate Alamar Blue assay (MABA).  The cytotoxic activities were performed by Sulforhodamine B (SRB) assay. The molecular docking and in silico ADME prediction were studied by using Schrodinger.Results: The results reveals that the compounds 9c, 9d, 10c and 10d exhibited substantial antitubercular potential with MIC < 20 μM. The cytotoxic studies revealed that the active compounds (9d, 10a, and 10d) are non-toxic to HeLa cancer cell lines with selectivity index >10. The molecular docking study was performed to study the binding orientation and affinity of synthesized compounds for InhA enzyme.Conclusion: The study explored that the 1, 3-diphenyl pyrazole hybrids coupled with well known antitubercular drugs could be a potential lead for antitubercular agents. In-silico molecular docking study helps to identify their corresponding intermolecular ligand-protein interactions with target enzyme. Also ADME prediction studies revealed that the compounds were in acceptable range to have pharmacokinetic parameters.
DETECTION OF INTERCELLULAR ADHESION GENES (ICA) IN STAPHYLOCOCCUS AUREUS CAUSING IMPLANT ASSOCIATED INFECTIONS
Authors: P. Prasanth , P. Saravanakumari
Published: November 2017

Objective:The complications related to implant associated infections in post-angioplasty patients were considered to increase due to biofilm formation.Methods: Genes responsible for the biofilm formation in the target organisms was investigated in the present study. The presence of the intercellular adhesion biofilm genes (icaA, icaB and icaD) was determined by the Polymerase Chain Reaction method. As preliminary investigations, standard tests, exit-site challenge test and microtitre plate method were used to study the biofilm efficiency of five different test organisms.Results: Exit-site challenge test, was used to identify the ability of test organisms to grow on a bio-materials used in the study. Among the five selected test organisms, Staphylococcus aureus showed the highest ability to colonize the stent materials with in 24h to 48h. In microtitre plate method, Staphylococcus aureus and Staphylococcus epidermidis showed high biofilm forming index values of 0.29 and 0.27 respectively. Biofilm gene studies using PCR revealed the presence of all the three ica genes (Ica A, Ica D and, Ica B) in Staphylococcus aureus. The present research finding has great significance in the treatment to implant associated infections.Conclusions: The results suggest that the virulence factors contributing to the development of infections can be revealed by understanding the presence of biofilm expression genes in the target organisms. This would also prevent dissemination of virulent bacteria in the health care centre; method also considered significant to detect healthy carriers of slime-producing staphylococci.
A PROSPECTIVE STUDY: KNOWLEDGE ASSESSMENT AND PATIENT CARE OF DIABETIC FOOT ULCER PATIENTS IN TERTIARY CARE HOSPITAL
Authors: Thomas Sheena Marin , Nitin Ishita Gajjar , Reddy M. Uday Kiran , S. Harsha Devi
Published: November 2017

Objective: To assess the knowledge with a diabetic foot ulcer, to evaluate the severity and grade of diabetic foot ulcer, to study the self-care behaviour and medication adherence in a patient with diabetic foot ulcer and to counsel the patients.Methods: The KAP, self-care foot behaviour and MMAS-8 questionnaire were given during interview; severity using Wagner’s scale was assessed. Knowledge, attitude, self-care foot practice and adherence was measured based on various parameters such as demographic factors, clinical characteristics, and medication taking characteristics. It was measured before and after the patient counselling to see improvement in the quality of life.Results: In the study period of 6 mo 111 cases were gathered. There were 74 (66%) patients who were illiterate; the patients with low economic status were 63 (56%). Patients who are illiterate have poor knowledge and poor self-care behaviour, in our study 74 (66%) are illiterate which improved after counselling and 59 patients with high knowledge. Medication adherence is also associated with the education of the patient. After counselling and providing knowledge most of the patients are having high KAP scores. Wagner’s scale for the study of the severity shows that most of the patients 30 out of 111 are having Grade 4 of the score which shows the need of counselling and education towards foot care. Improvement in the self-care practice and on safety and prevention was seen after counselling.Conclusion: Knowledge, attitude, self-care practice and adherence of the patient can be improved by establishing a good patient-provider relationship and giving proper patient counselling to the patient or their relatives.
ASSESSMENT OF TWO OR MORE ANTIBIOTICS REGIMEN VERSUS ONE OR NO ANTIBIOTIC REGIMEN IN POST-OPERATIVE SURGERY
Authors: B. Mihirkumar , S. Ashley , S. Nawaz , G. Surekha , Paarakh Padmaa M.
Published: November 2017

Objective: Surgical site infections [SSI] are the leading cause of hospital-acquired infections. The objective of this study was to evaluate whether surgical site infections can be reduced with two or more antibiotics regimen versus one or no antibiotic regimen in post-operative surgery.Methods: The patients were grouped into 2 groups. Group A (two or more antibiotics regimen) and Group B (one or no antibiotic regimen). Then the patients were followed on 1st, 2nd, 3rd and 4th week respectively after surgery to check for any surgical site infection by direct interviewing the patients. Results: The overall surgical site infection rate was 48.3 % (58 out of 120 patients). However, this study was more dominated by female patients–there were 63% female patients compared to 37 % male patients enrolled in this study. Also, the post-operative surgical site infection was comparatively observed more in female patients than in male. General surgery department too had many gynaecology related patients followed by Orthopaedic and Endocrinology surgeries. Results revealed that the patients in Group A (Two or more antibiotics) had significantly lower number of surgical site infections when compared with Group B (One or no antibiotics) with p<0.001.Conclusion: Our study concludes that patients receiving two or more antibiotics had significantly less number of post-operative surgical site infections when compared to patients receiving one or no antibiotics and following two or more antibiotics can reduce the excess hospital cost.