bluuebunny/crossref_metadata_2025 huggingface dataset:
Empowering self-direction in return to work of employees with low and high levels of education: A qualitative comparative study
Authors: Hoefsmit Nicole , Pennings Bart , Houkes Inge
Published: November 2022

BACKGROUND: Dutch legislation encourages active participation of employees in their return-to-work (RTW) process. Empowering leadership may support employees’ self-direction in this process (i.e. by allowing and enabling their involvement in decision-making). OBJECTIVE: Building upon a previous study, we aimed to study (1) how representatives of a university, i.e. an employer for employees with high levels of education (EH), manage RTW, (2) the similarities and differences between the RTW management of employers (or representatives thereof) of employees with low (EL) and high levels of education, and (3) the degree to which the employers’ roles resemble empowering leadership. METHODS: Qualitative methodology was applied. A thematic analysis of interview transcripts (rq1) was followed by a comparison of themes (rq2) and pattern matching (rq3). RESULTS: (1) EH tend to engage in dialogue and accommodate their employees as much as possible. (2) EL and EH showed several similarities, such as aiming to meet legal requirements on RTW management. Compared to EL, EH tend to focus more on facilitating employees. (3) Empowering leadership seems to be more common among EH. CONCLUSIONS: Compared to employees with low levels of education, those with high levels of education may be granted more opportunity to self-direct their RTW. The study results provide starting points for employers for employees with both low and high levels of education who aim to enable employees’ self-direction in RTW, and help them to develop empowering leadership styles.
Exploring acute effects of workplace warm-up intervention on pain, physical capacities, and productivity in agriculture: A study protocol
Authors: Larinier Nicolas , Vuillerme Nicolas , Jadaud Alexandre , Malherbe Solène , Balaguier Romain
Published: November 2022

BACKGROUND: Physical activity programs at the workplace have shown positive results on physical capacities and pain for several years. Due to the duration of the training session or the need for an instructor, these supervised programs are rather difficult to implement. For this reason, numerous companies, especially companies in manual sectors, are turning to another solution, i.e. warm-up intervention before the work shift. These interventions present various advantages such as short duration and the possibility to perform exercises in working clothes. Surprisingly, while the positive effects of warm-up interventions on pain, performance, and physical and psychological capacities are expansively reported in the sport context, effects of workplace warm-up intervention are lacking. OBJECTIVE: The aim of this study is to assess the acute effects of three different warm-up interventions on physical (pain, strength, flexibility) and psychological (workload) functions and also on work-related outcomes (work performance, readiness to work) among vineyard workers. METHODS: A cluster randomized study will be implemented among French vineyard workers. Four groups of 30 participants will be constituted; corresponding to four different conditions: (1) hybrid warm-up intervention (HWU); (2) dynamic warm-up intervention (DWU); (3) stretching warm-up intervention (SWU); (4) no warm-up intervention (NWU). A total of 120 vineyard workers will be recruited to participate in the study. CONCLUSION: The results will provide more evidence about the short-term effects of warm-up interventions at the workplace and will provide more evidence on which warm-up modality is the most effective on pain, performance, and physical and psychological capacities among vineyard workers.
Technological quality of wheat grains and flour as affected by nitrogen fertilization and weather conditions
Authors: de Lucena Marinho Jéssica , Silva Sergio Ricardo , de Batista Fonseca Inês Cristina , de Miranda Martha Zavariz , Guarienti Eliana Maria , Zucareli Claudemir
Published: November 2022

The quality of grains and flour can be influenced by genetics, crop management, and the environment. The objective of this study was to evaluate the technological quality of wheat grains and flour influenced by the interaction among genotype, nitrogen (N) fertilization and weather conditions in different regions of wheat crop adaptation in southern Brazil, aiming to support farmers and the bakery industry sector in their decision-making processes. The experiment was carried out in three environments (Londrina in rainfed and irrigated conditions; and Ponta Grossa in rainfed) in a randomized block design with a 10 × 2 factorial scheme. Ten wheat genotypes (BRS Sanhaço, BRS Graúna, BRS Gaivota, BRS Gralha-Azul, TBIO Sinuelo, TBIO Mestre, TBIO Sossego, TBIO Sintonia, TBIO Toruk, and Quartzo) and two N rates (40 and 120 kg ha-1) were assessed. The following technological quality analyses were performed in grains or flour: hectoliter weight, thousand-kernel weight, falling number, grain protein concentration, experimental flour extraction (i.e. flour yield), wet gluten concentration, and alveography. Increasing N rates from 40 to 120 kg ha-1 enhanced the concentrations of grain protein and wet gluten. However, it did not influence dough gluten strength and the commercial classification of the flour. Nitrogen fertilization also influenced the flour yield, dough tenacity and elasticity index, depending on the genotype × environment interaction. Environments with higher temperatures favored the flour yield and wet gluten concentration, while lower temperatures increased the thousand-kernel weight and falling number. Water deficit increased the dough extensibility and grain protein concentration, whereas higher water availability favored the falling number, dough tenacity, and tenacity/extensibility ratio. Therefore, these outcomes are important drivers for farmers when choosing specific wheat genotypes for the environmental conditions of their farms, when they intend to meet the industrial requirements of mills and food companies that use wheat flour.
Lipid profile and apolipoprotein A1 and B levels in women with pre- and postmenopausal breast cancer undergoing neoadjuvant therapy
Authors: Ramírez-Expósito María Jesús , Carrera-González María Pilar , Martínez-Martos José Manuel
Published: November 2022

Breast cancer is associated with modifiable risk factors such as diet and obesity. In this sense, the circulating levels of apolipoproteins and lipoproteins such as LDL cholesterol or HDL cholesterol could be involved in tumor development and be modified by them. Also, the hormonal profile of the patients seems to be a decisive factor in the progression of the disease, as well as determining, to a certain extent, the presence of obesity in postmenopausal women.

In this context, the purpose of this work has been to determine the levels of lipoproteins, specifically, LDL cholesterol and HDL cholesterol, using standard enzymatic colorimetric methods, as well as apolipoproteins ApoA1 and ApoB, using specific ELISA kits, in pre- and postmenopausal women with breast cancer treated or not with neoadjuvant chemotherapy in comparison with healthy pre- and postmenopausal women.

The significant differences obtained between groups of patients studied at the levels of lipoproteins and apolipoproteins, lead us to conclude that the hormonal profile is decisive to regulate lipid metabolism and that it is possibly involved in the progression of the disease according to the administration or not of neoadjuvant chemotherapy, mainly in postmenopausal women.
Simulating Quar-Maharlu Aquifer in Fars Province, Iran, and Optimizing Artificial Recharge Using PMWIN Model
Authors:   Department of Civil Engineering, Faculty of Engineering, Shiraz University, Shiraz, Iran., Talebi Soheil , Rakhshandehro Gholamreza ,   Department of Civil Engineering, Faculty of Engineering, Shiraz University, Shiraz, Iran., ParsiMehr Mohamad ,   Department of Environment, Faculty of Natural Resources and Environment, Malayer University, Malayer, Hamedan, Iran., Rezaei Shima ,   Department of Environmental Health Engineering, Environmental Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Published: November 2022

Background: The improper exploitation of water resources by humans has disrupted the natural balance of groundwater. Given the water resources restriction, it is crucial to manage these resources properly, recognize the current situation, and anticipate the harvesting or feeding effects. In this regard, simulators or models can act as valuable tools. Methods: In this research, we performed quantitative modeling of groundwater flow in the Quar-Maharlu plain, Fars Province, Iran using the PMWIN software. The model included three years’ calibration (2011-2014) for hydraulic conductivity coefficient and one year’s verification (2014-2015). To evaluate the model error in calibration and verification, the root mean square deviation (RMSD) was used. After simulating the aquifer to optimize the artificial recharge location by the flood spreading method, different scenarios were defined and examined by considering the natural and artificial factors. Results: The RMSD values for calibration were 1.55, 1.49, and 1.56 m for 2011, 2012, and 2013, respectively. The RMSD for verification of one year was 1.77 m, indicating the acceptable ability of the model to predict groundwater flow parameters. The stock variation for the whole aquifer was -8.88 mm3 in 2014. In the next step, the best recharging location was selected to create the maximum head increase (5.3cm) in the entire area of the plain. Conclusion: One of the effective ways to offset the negative balance is to strengthen the aquifer through artificial recharge.
From Environmental Accounting to Integrated Reporting: Towards a New Approach to Environmental Disclosure
Authors:   Department of Accounting, Science and Research Branch, Islamic Azad University, Tehran, Iran., Abbasabadi Yaser
Published: November 2022

To pay attention to environmental issues and problems in today’s modern economy, especially in academia, is a valuable orientation. Cooperation between related organizations about environmental issues is now more important than before. It has covered environmental reporting in several complementary stages. In addition, it has established its new reporting based on the field of environmental disclosure. The latest version of reporting is the integrated reporting, which is the most important environmental disclosure. Usually, any new version on any topic should cover the limitations of the previous version. This paper is a review study. In this study, environmental accounting and its limitations are first explained. Integrated reporting is then discussed as the newest type of financial and non-financial reporting. Finally, the possibility of covering the environmental accounting constraints is examined through integrated reporting. The results showed that the transparency in environmental accounting figures, democratization and information linkages are likely to be achieved through the implementation of integrated reporting. Therefore, it will be effective in covering the limitations of environmental accounting.
A new ‘Brazilian Revolution’: maoism to struggle against militar dicatatorship in Brazil (1960´s – 1970´s)
Authors:   Universidad Federal de Pernambuco, Dabat Christine , Craveiro Thaís ,   University of Chelyabinsk
Published: November 2022

In a world where Asia occupies again her historical role, after two centuries of European and North American domination – an “aberration”, according to Kishore Mahbubani –, the lega-cy of traditions from this continent in Latin American in-tellectual life and politics appears slightly. Thus maoism in-formed several political currents and generations of political activists, such as PCB, AP or PCdoB. Apart from definitions, they were interested in the way of thinking of Chinese communists, unlikely winners, which opened perspectives as to how to conceive revolution in Brazil in a way more cohe-rent with its historical originality, geographical complexity, and level of development. Aspects formerly seen as hindran-ces became beacons of hope: rural economic preponderance, especially peasant struggles in the Northeast or Maringa etc. Some examples from the continent favoured this bet. Ten years after the proclamation of the People's Republic of Chi-na, a Cuban revolutionary movement achieved power coming from the rural areas. The phrase “the countryside surrounds the city”, gaining power in the 1960´s, seemed to be realized here as well as with national liberation wars in Viet Nam, Asia, Africa and Latin America (Naxalites, MPLA, Sendero luminoso etc.). For young Brazilian activists, under strong repression from the military dictatorship since 1964, especially with AI 5 in 1968, maoism offered a new horizon. Apart from the change in model, perspectives opened in the arts, or currents such as feminism etc., the Little Red Book (although clandestine) representing an incentive to struggle, and a solidarity link with other fighters around the world.
CHEMOMETRIC ANALYSIS OF THE WATER OF SITNICA RIVER
Authors:   University of Pristina “Hasan Prishtina”, Limani Hajnuni V. ,   Agricultural University
Published: November 2022

The purpose of this study is to determine the water quality of the Sitnica river through the research and determination of some physico-chemical parameters of this water and the degree of pollution with heavy metals and various effluents along the entire flow of the river, within the borders of Republic of Kosovo. The geographical positions of sampling spots were determined by GPS, make GARMIN GEKO, 12 сhannel. The number of sampling spots is 9, and samples in every sampling spot were taken to determine the chemical parameters.The tracking of heavy materials is done through the ICP-MS and ICP-OES method. Following the results of our analyses it found that the temperature is almost unchanged and it is between 11.5 and 12 degrees. Electrical conductivity, starting from the spring, is increasing and it reaches the maximum rate (840 μS/cm) at point S5 (Palaj) as a consequence of industrial water spill and other anthropogenic polluters and again after that it starts to drop down along the flow of the river. The pH of water is between 7.83 in S1(Jezerc) and 8.6 in S3 (Lipjan). The turbidity is also increasing in S5. Total hardness reaches the maximum rate in S4 (Lismir), but it drops again, while the alkalinity reaches the maximum rate in S5. At sampling spot S4, metals Ni, Co, Si, Zn are noted for the maximum concentration comparing to other points, except in sampling spot S9(Mitrovica), where the rate is over 250 μg/dm3 . At the sampling point S9, the maximum content of cadmium is observed, at the point S2( Rubovich) - iron, at the point S1 – chromium. According to the performed chemical analysis, it can be concluded that the pollution of the Sitnitsa River is caused by anthropogenic sources, especially at sampling points S4, S5, S6 (Plemetin) and S9. Namely, where the river Drenica flows into Sitnica, which carries the industrial waters of the ferronickel plant (S4), then S5 and S6, where industrial waters come from thermal plants, and S9, where industrial waters come from the ore smelter in Mitrovica.
JOINT RECYCLING MSW SLAG AND DRILL CUTTINGS INTO MINERAL FERTILIZERS WITH LEAN-GRADE PHOSPHORITE
Authors:   Azerbaijan State Oil and Industry University, Garaybeyli S.A.
Published: November 2022

: The possibility of joint utilization of municipal solid waste (MSW) slag and drill cuttings by their recycling into complex mineral fertilizers through the use of lean-grade phosphorite as a source of phosphorus has been considered. Also, the recycling of three-component raw materials has been carried out with 50-65% sludge sulfuric acid from the propylene hydration process at 80°C. The consumption rate of sulfuric acid required to obtain mineral fertilizers with a sufficient content of Р2О5assim. has been determined with due regard for the presence of the increased content of sesquioxides in the drill cuttings. Comparative results of the recycling MSW with phosphorite and three-component raw materials confirming the absence of harmful effect of drill cuttings on the recycling process and the role of the nature of the used sulfuric acid on the parameters of the recycling process have been shown.
BIOCIDAL ACTIVITY OF AMINOMETHYL DERIVATIVES OF 2-MERCAPTOBENZOXAZOLE
Authors:   Acad. A. Guliyev Institute of Chemistry of Additives, Safarova L.R.
Published: November 2022

The biocidal activity of the aminomethyl derivatives of 2-mercaptobenzoxazole synthesized by us and being of interest as potential antimicrobial additives to petroleum products and cutting fluids, was studied. The aminomethylation reaction proceeded with the participation of methylene-bis-amines. As a result, the appropriate N-substituted benzoxazolin-2-thiones were obtained. Their structure was proved by NMR 1H. Due to the poor solubility of the synthesized compounds in petroleum products, their salts with petroleum naphthenic acid were obtained for microbiological testing. The results of tests in lubricating oil M-8 show that the naphthenic salts of the synthesized compounds exhibit biocidal activity and their fungicidal properties are higher than bactericidal ones. The petroleum naphthenic acid used in the test in its pure form in the composition of the M-8 lubricating oil is not biostable and is affected by microorganisms. N-piperidinomethylbenzoxazolin-2-thione in the composition of the coolant proved to be a biocide, and its bactericidal properties are higher than fungicidal ones. The results of a microbiological study of an aqueous solution of this compound showed high bactericidal properties in the absence of effectiveness against mold fungi.
SYNTHESIS OF AN OPTICALLY TRANSPARENT COPOLYMER ON THE BASIS OF NVINYL CARBAZOLE AND STYRENE
Authors:   Institute of Polymer Materials of Azerbaijan National Academy of Sciences, Mammadli S.B. , Amirov F.A. ,   Azerbaijan State University of Oil and Industry, Alamdarlyı A.V. ,   Institute of Polymer Materials of Azerbaijan National Academy of Sciences, Orucaliyeva U.B. ,   Azerbaijan State University of Oil and Industry, Nurullayeva D.R. ,   Institute of Polymer Materials of Azerbaijan National Academy of Sciences
Published: November 2022

As a result of copolymerization of N-vinyl carbazole with styrene, the optically transparent copolymer was synthesized and the regularities of the copolymerization process, the composition and structure of the copolymer determined. The copolymerization constant values were determined by the Fineman–Ross method (r1=0.032, r2=5.5). It found that the styrene shows higher activity than N-vinyl carbazole. The parameters value of the copolymer microstructure was reveled. The obtained copolymer has a sufficiently high light-refractive index ( 20 nD =1.6504). The light transmission capacity of the copolymer is 87-89%. Varying the initial composition of the copolymer, the influence of the composition on the physicalmechanical properties of the copolymer was determined. It found that with an increase in N-vinyl carbazole links, the thermal stability in the copolymer increased proportionally. It was established that the mass loss of this copolymer at 280°C during thermal degradation was 5-6 %.
КОНКУРЕНТОСПРОМОЖНІСТЬ ПРОДУКЦІЇ ТВАРИННИЦТВА В КОНТЕКСТІ СУЧАСНИХ ВИКЛИКІВ АГРАРНОЇ ПОЛІТИКИ
Authors: Перегуда Ю.А.
Published: November 2022

Волатильність екзогенного та ендогенного середовища зумовлює значні ускладнення для сучасного стану та перспектив розвитку галузі тваринництва. Ключовий прояв даних викликів виявляється в необхідності актуалізації аграрної політики держави. Метою статті є виявлення драйверів конкурентоспроможності галузі тваринництва в площині сучасних викликів аграрної політики держави. В статті здійснено аналіз ключових факторів впливу на стан конкурентоспроможності продукції тваринництва в контексті аграрної політики держави. Виявлено потенційні напрями покращення аграрної політики України в контексті сучасних викликів зовнішнього та внутрішнього середовища. В результаті аналізу виділено ключові пріоритети аграрної політики держави в розрізі нормативно-правових і регуляторних документів. Запропоновано вжити заходів, що згладжують суттєві розбіжності в масиві нормативно-правових і регуляторних документів, що визначають аграрну політику на національному та міжнародному рівні. Перспективами майбутніх досліджень є розвиток нормативно-правової та регуляторної бази аграрної політики в розрізі ключових викликів.
EVALUASI TARIF ANGKUTAN UMUM BERDASARKAN STANDARISASI PEMERINTAH DAERAH KABUPATEN PULAU MOROTAI
Authors: Thaib Aminullah , Idrus Sukirman
Published: November 2022

Penelitian ini bertujuan sebagai bahan evaluasi penentuan tarif angkutan umum dalam pelaksanaannya tanpa merugikan pengguna angkutan maupun penyedia jasanya. Metode yang digunakan dalam penelitian ini yaitu metode penelitian deskriptif analitis, yaitu penelitian yang bukan bersifat eksperimen akan tetapi dimaksudkan untuk mengumpulkan data-data yang dibutuhkan berupa data primer dan data sekunder yang selanjutnya dipakai untuk proses analisis data. dari hasil penelitian ini diperoleh tarif roda tiga (bentor) Rp. 2.484,93/km, dan tarif mini bus Rp. 2.806,47/km. Terjadi perbedaan antara SK Bupati dan analisis hasil perhitungan yaitu untuk tarif roda tiga (bentor) sebesar 19,51%, dan tarif mini bus sebesar 10,92%.
DEDE KORKUT’TAKİ BAYINDIR HAN ÜZERİNE BİR DEĞERLENDİRME
Authors: EYÜBOĞLU Dursun Can
Published: November 2022

Türk tarihinde, Türk kültüründe ve Türk halk edebiyatında destanlar önemli bir yere sahip olup, Türk destan geleneğinin kökleri tarihin erken devirlerine kadar uzanmaktadır. Dede Korkut Destanları; Türk destanları içerisinde önemli bir yere sahiptir; eski Türk yaşamının bir yansımasıdır; Türk tarihi, coğrafyası, dili, edebiyatı, kültürü, sanatı ve daha birçok konu hakkında önemli bilgiler içermektedir. Dede Korkut’ta birçok kişi adı geçmektedir. Bunlardan biri Bayındır Han’dır. Bayındır Han’ın adı Dede Korkut Kitabı’nda dokuz boyda geçmektedir. Dede Korkut Kitabı’nda çoğunlukla Bayındır Han’ın tarihi ve sembolik kişiliği baskın olup, efsanevi-mitolojik kökleri zayıftır. Oğuz Han’ın hükümdarlık hatıraları da kısmen Dede Korkut’ta Bayındır Han tipine yansımıştır. Dede Korkut’ta önemli bir yere sahip olan, destandaki en üst yönetici olan Bayındır Han tipinde birçok tarihi-destani-efsanevi-mitolojik tabaka bulunmaktadır. Dede Korkut’taki Bayındır Han tipinin önemli bir tarihi tabakası 2. (Doğu) Gök-Türk Devleti hükümdarı Bilge Kağan (716-734) ile ilgilidir. Akkoyunlu etkisinden uzak, Salur boylarının önemli bir yer tuttuğu Türkmenistan varyantında Bayındır Han’ın aktif bir rol üstlendiği görülmektedir. Bu durum Bayındır Han’ın tıpkı Salur Kazan gibi, Dede Korkut’ta eskiden beri mevcut olduğunu göstermektedir. Dede Korkut’taki bazı destanlarda Bayındır Han ile Salur Kazan’ın şahsiyetlerinin karıştırıldığı da görülmektedir. Bu makalede, Dede Korkut’taki Bayındır Han; adı, ailesi, tarihteki, Dede Korkut’taki ve destanlardaki yeri incelenmiştir.
The Effect of Kinesiological Taping on Pain, Function, and Disability in Subacromial Impingement Syndrome - A Randomized Controlled Study
Authors: Büyüktepe Yeliz , Şenocak Emre , Yıldız Özer Aysel
Published: November 2022

Objective: Subacromial Impingement Syndrome (SIS) is one of the most common shoulder pathologies that cause pain and lose of function. This study aimed to compare the effects of kinesiological taping and conventional physiotherapy (CP) on pain, functionality, and disability in SIS patients.Materials and Methods: The study was completed with 54 patients aged 18-60 years. By randomization, the participants were divided into two groups: The Intervention Group (IG) and the Control Group (CG). While the CP was performed for ten sessions, kinesiological taping was repeated every three days for the IG. The CG was taken to only ten sessions of CP. The CP was applied for 60x5x2 minutes/day/week. Pain severity, function, and disability were assessed before and after the treatment.Results: There was no difference between the groups in pain severity (p=0.074), function (p=0.565), and disability (p=0.315) scores. On the other hand, there were significant improvements in pain (p=0.001), function (p=0.001), and disability (p=0.005) scores of IG according to intra-group analysis. Similar results were obtained in the CG. However, when the effect sizes of these treatment methods were examined, they did not create a clinically significant superiority compared to each other.Conclusion: Kinesiological taping has been widely used in patients with orthopedic problems. According to our results, kinesiological taping did not have a clinical effect in reducing pain, improving function and disability when applied with CP compared to CP alone. We think that only kinesiological taping may not be sufficient be an alternative to traditional methods in the early term.
Burnout, Anxiety and Coping Attitudes in Parents of Children with Autism Spectrum Disorder
Authors: Ulu A. Ezgi , Karacasu Güner
Published: November 2022

Objective: In this study, the relationship between burnout level, anxiety and coping attitudes of parents with children diagnosed with autism spectrum disorder (ASD) was examined together with demographic variables. Methods: Relational model was used in the research. The research was conducted with the parents of 180 children diagnosed with ASD. Data were obtained using the Beck Anxiety Inventory (BAI), Maslach Burnout Inventory (MBI), and the Coping Attitudes Rating Scale (COPE). T Test, One Way Analysis of Variance (ANOVA) and Pearson correlation analysis were used in the analysis of the data. Results: In the research findings, it was observed that the burnout level of the parents differed according to the age groups of the autistic children, the number of siblings and the psychiatric disease history of the parents. In addition, it was observed that the anxiety level and coping methods of the parents differed significantly according to the psychiatric illness history of the parents. A strong positive correlation was found between parents' anxiety and burnout levels. A moderate positive relationship was also found between the emotional burnout levels of the parents and their coping levels. Conclusion: It was observed that the levels of anxiety and burnout were lower in parents who used the problem-focused coping method. In addition, it has been observed that parents overcome problems by using problem-focused coping methods and this situation affects their lives positively. In addition, it was observed that parents with high levels of anxiety and burnout used dysfunctional coping methods more.
Futbolcularda Sabah Akşam Yapılan Yo-Yo Aralıklı Toparlanma Testinin (Seviye 1) Hematolojik Parametreler Üzerine Akut Etkisi
Authors: Yapıcı Öksüzoğlu Ayşegül , Fındıkoğlu Gülin
Published: November 2022

Bu çalışmanın amacı, sabah ve akşam yapılan Yo-Yo aralıklı toparlanma testinin seviye 1 (YIRT1) hematolojik parametreler üzerine akut etkisinin incelenmesidir. Çalışmaya Süper Amatör liginde oynayan bir futbol takımından 18 erkek futbolcu gönüllü olarak katılmıştır. Sporculara 2 farklı günde, sabah ve akşam olmak üzere YIRT1 testi uygulanmıştır. Kan örnekleri testten önce, testten sonra ve testten 2 saat sonrasında alınmıştır. Test sırasında, deneklerin kat ettikleri mesafe kaydedilmiştir. Test bitiminde kan laktat değerleri ölçülmüştür. Tam kan sayımı için lökosit (WBC), Nötrofil (NEU), Nötrofil yüzde (NEU %), Lenfosit (LYM), Lenfosit yüzde (LYM %), Eritrosit (RBC), Hemoglobin (HGB), Hematokrit (HCT) ve Trombosit (PLT) değerleri incelenmiştir. İstatistiksel analizde verilerin normal dağılıma uygunluğu Shapiro Wilk testi ile incelenmiştir. Veriler normal dağılım gösterdiğinden, bağımlı grup farklılıkların karşılaştırılmasında bağımlı gruplarda t test ve Tekrarlı ölçümlerde tek yönlü varyans analizi testi (ANOVA) kullanılmıştır. YIRT1 testi sonrasında hematolojik parametrelerde, kan laktat ve test sonu kat edilen mesafe değerlerinde sabah ve akşam ölçümleri arasında istatistiksel olarak anlamlı fark vardır (p<0.05). Sonuç olarak futbolculara uygulanacak YIRT1 testinin akşam saatlerinde yapılması önerilebilir. Oyuncuların fiziksel kapasitesini belirlemek için kullanılan bu testin hematolojik değerleri etkilediği bulunmuştur.
Quantum Sensors for the Hidden Sector (QSHS) - A Summary of Our First Year!
Authors: Bailey Ian , Chakraborty Bhaswati , Chapman Gemma , Daw Ed , Hao Ling , Hardy Edward , Laird Edward , Leek Peter , Gallop John , Gregori Gianluca , March-Russell John , Meeson Phil , Mostyn Clem , Pashkin Yuri , O Peatain Searbhan , Perry Mitch , Piscitelli Michele , Romans Edward , Sarkar Subir , Song Ningqiang , Soni Mahesh , Smith Paul , Tan Boon-Kok , West Stephen , Withington Stafford
Published: November 2022

In 2021 the Quantum Sensors for the Hidden Sector (QSHS) collaboration was founded in the UK. We received funding as part of the Quantum Technologies for Fundamental Physics programme to develop and demonstrate quantum devices with the potential to detect hidden-sector particles such as axions and dark photons in the ~1μeV/c^2 to ~100μeV/c^2 mass window. Our collaboration is formed from a diverse community of condensed matter physicists, quantum technologists, theorists and (astro) particle physics experimentalists. We are designing and fabricating a range of “quantum devices” and constructing a high-field, low-temperature facility at the University of Sheffield to characterise and test the devices in an axion haloscope geometry, initially using an rf cavity. This poster was presented at the 17th Patras workshop on axions, WIMPs and WISPs on the 8th August 2022 in Mainz, Germany.
Label-free multimodal nonlinear optical microscopy reveals features of bone composition in pathophysiological conditions
Authors: Talone Benedetta , Bresci Arianna , Manetti Francesco , Vernuccio Federico , De la Cadena Alejandro , Ceconello Chiara , Schiavone Maria Lucia , Mantero Stefano , Menale Ciro , Vanna Renzo , Cerullo Giulio , Sobacchi Cristina , Polli Dario
Published: November 2022

Bone tissue features a complex microarchitecture and biomolecular composition, which determine biomechanical properties. In addition to state-of-the-art technologies, innovative optical approaches allowing the characterization of the bone in native, label-free conditions can provide new, multi-level insight into this inherently challenging tissue. Here, we exploited multimodal nonlinear optical (NLO) microscopy, including co-registered stimulated Raman scattering, two-photon excited fluorescence, and second-harmonic generation, to image entire vertebrae of murine spine sections. The quantitative nature of these nonlinear interactions allowed us to extract accurate biochemical, morphological, and topological information on the bone tissue and to highlight differences between normal and pathologic samples. Indeed, in a murine model showing bone loss, we observed increased collagen and lipid content as compared to the wild type, along with a decreased craniocaudal alignment of bone collagen fibres. We propose that NLO microscopy can be implemented in standard histopathological analysis of bone in preclinical studies, with the ambitious future perspective to introduce this technique in the clinical practice for the analysis of larger tissue sections.
MRI-based machine learning model: A potential modality for predicting cognitive dysfunction in patients with type 2 diabetes mellitus
Authors: Xu Zhigao , Zhao Lili , Yin Lei , Liu Yan , Ren Ying , Yang Guoqiang , Wu Jinlong , Gu Feng , Sun Xuesong , Yang Hui , Peng Taisong , Hu Jinfeng , Wang Xiaogeng , Pang Minghao , Dai Qiong , Zhang Guojiang
Published: November 2022

Background: Type 2 diabetes mellitus (T2DM) is a crucial risk factor for cognitive impairment. Accurate assessment of patients’ cognitive function and early intervention is helpful to improve patient’s quality of life. At present, neuropsychiatric screening tests is often used to perform this task in clinical practice. However, it may have poor repeatability. Moreover, several studies revealed that machine learning (ML) models can effectively assess cognitive impairment in Alzheimer’s disease (AD) patients. We investigated whether we could develop an MRI-based ML model to evaluate the cognitive state of patients with T2DM.

Objective: To propose MRI-based ML models and assess their performance to predict cognitive dysfunction in patients with type 2 diabetes mellitus (T2DM).

Methods: Fluid Attenuated Inversion Recovery (FLAIR) of magnetic resonance images (MRI) were derived from 122 patients with T2DM. Cognitive function was assessed using the Chinese version of the Montréal Cognitive Assessment Scale-B (MoCA-B). Patients with T2DM were separated into the Dementia (DM) group (n = 40), MCI group (n = 52), and normal cognitive state (N) group (n = 30), according to the MoCA scores. Radiomics features were extracted from MR images with the Radcloud platform. The variance threshold, SelectKBest, and least absolute shrinkage and selection operator (LASSO) were used for the feature selection. Based on the selected features, the ML models were constructed with three classifiers, k-NearestNeighbor (KNN), Support Vector Machine (SVM), and Logistic Regression (LR), and the validation method was used to improve the effectiveness of the model. The area under the receiver operating characteristic curve (ROC) determined the appearance of the classification. The optimal classifier was determined by the principle of maximizing the Youden index.

Results: 1,409 features were extracted and reduced to 13 features as the optimal discriminators to build the radiomics model. In the validation set, ROC curves revealed that the LR classifier had the best predictive performance, with an area under the curve (AUC) of 0.831 in DM, 0.883 in MIC, and 0.904 in the N group, compared with the SVM and KNN classifiers.

Conclusion: MRI-based ML models have the potential to predict cognitive dysfunction in patients with T2DM. Compared with the SVM and KNN, the LR algorithm showed the best performance.
Crosstalk between liver macrophages and gut microbiota: An important component of inflammation-associated liver diseases
Authors: Zhou Ziyuan , Pan Xiaxia , Li Lanjuan
Published: November 2022

Hepatic macrophages have been recognized as primary sensors and responders in liver inflammation. By processing host or exogenous biochemical signals, including microbial components and metabolites, through the gut-liver axis, hepatic macrophages can both trigger or regulate inflammatory responses. Crosstalk between hepatic macrophages and gut microbiota is an important component of liver inflammation and related liver diseases, such as acute liver injury (ALI), alcoholic liver disease (ALD), and nonalcoholic fatty liver disease (NAFLD). This review summarizes recent advances in knowledge related to the crosstalk between hepatic macrophages and gut microbiota, including the therapeutic potential of targeting hepatic macrophages as a component of gut microecology in inflammation-associated liver diseases.
Development of QSRR model for hydroxamic acids using PCA-GA-BP algorithm incorporated with molecular interaction-based features
Authors: Nie Yiming , Li Jia , Yang Xinying , Hou Xuben , Fang Hao
Published: November 2022

As a potent zinc chelator, hydroxamic acid has been applied in the design of inhibitors of zinc metalloenzyme, such as histone deacetylases (HDACs). A series of hydroxamic acids with HDAC inhibitory activities were subjected to the QSRR (Quantitative Structure–Retention Relationships) study. Experimental data in combination with calculated molecular descriptors were used for the development of the QSRR model. Specially, we employed PCA (principal component analysis) to accomplish dimension reduction of descriptors and utilized the principal components of compounds (16 training compounds, 4 validation compounds and 7 test compounds) to execute GA (genetic algorithm)-BP (error backpropagation) algorithm. We performed double cross-validation approach for obtaining a more convincing model. Moreover, we introduced molecular interaction-based features (molecular docking scores) as a new type of molecular descriptor to represent the interactions between analytes and the mobile phase. Our results indicated that the incorporation of molecular interaction-based features significantly improved the accuracy of the QSRR model, (R2 value is 0.842, RMSEP value is 0.440, and MAE value is 0.573). Our study not only developed QSRR model for the prediction of the retention time of hydroxamic acid in HPLC but also proved the feasibility of using molecular interaction-based features as molecular descriptors.
Antiplatelet efficacy of ticagrelor versus clopidogrel in Mediterranean patients with diabetes mellitus and chronic coronary syndromes: A crossover pharmacodynamic investigation
Authors: Marcano Ana Lucrecia , Gracida Montserrat , Roura Gerard , Gomez-Lara Josep , Romaguera Rafael , Teruel Luis , Fuentes Lara , Muntané-Carol Guillem , Meroño Oona , Sosa Silvia Gabriela , Gómez-Hospital Joan Antoni , Comin-Colet Josep , Ferreiro José Luis
Published: November 2022

Introduction

Patients with diabetes mellitus (DM) have augmented platelet reactivity and diminished responsiveness to clopidogrel. Ticagrelor, a more potent P2Y12 inhibitor, is clinically superior to clopidogrel in acute coronary syndromes, although its role in chronic coronary syndromes (CCS) is still the subject of debate. The aim of this investigation was to compare the pharmacodynamic effectiveness of ticagrelor and clopidogrel in Mediterranean DM patients with CCS.

Materials and methods

In this prospective, randomized, crossover study, patients (n = 20) were randomized (1:1) to receive, on top of aspirin therapy, either ticagrelor 180 mg loading dose (LD)/90 mg maintenance dose (MD) b.i.d. or clopidogrel 600 mg LD/75 mg MD o.d. for 1 week in a crossover fashion with a 2–4 week washout period between regimens. Platelet function measurements were performed at 4 timepoints in each period (baseline, 2 h and 24 h after LD, and 1 week), including light transmission aggregometry (LTA, primary endpoint), VASP assay, Multiplate and VerifyNow P2Y12.

Results

The ticagrelor LD achieved greater platelet inhibitory effect than clopidogrel LD, assessed with LTA (20 μM ADP as agonist), at 2 h (34.9 ± 3.9% vs. 63.6 ± 3.9%; p < 0.001) and 24 h (39.4 ± 3.5% vs. 52.3 ± 3.8%; p = 0.014). After 1 week of therapy, platelet reactivity was again significantly inferior with ticagrelor compared to clopidogrel (30.7 ± 3.0% vs. 54.3 ± 3.0%; p < 0.001). The results were consistent with the other platelet function assays employed.

Conclusion

In Mediterranean patients with DM and CCS, ticagrelor provides a more potent antiplatelet effect than clopidogrel after the LD and during the maintenance phase of therapy.

Clinical trial registration

[ClinicalTrials.gov], identifier [NCT02457130].
Induced microearthquakes predict permeability creation in the brittle crust
Authors: Li Ziyan , Elsworth Derek , Wang Chaoyi ,   EGS-Collab
Published: November 2022

Predicting the evolution of permeability accurately during stimulation at the reservoir scale and at the resolution of individual fractures is essential to characterize the fluid transport and the reactive/heat-transfer characteristics of reservoirs where stress exerts significant control. Here, we develop a hybrid machine learning (ML) model to visualize in situ permeability evolution for an intermediate-scale (∼10 m) hydraulic stimulation experiment. This model includes an ML model that was trained using the well history of flow rate and wellhead pressure and MEQ data from the first three stimulation episodes to predict average permeability from the statistical features of the MEQs alone for later episodes. Moreover, a physics-inspired model is integrated to estimate in situ fracture permeability spatially. This method relates fracture permeability to fracture dilation and scales dilation to the equivalent MEQ magnitude, according to laboratory observations. The seismic data are then applied to define incremental changes in permeability in both space and time. Our results confirm the excellent agreement between the ground truth and model-predicted permeability evolution. The resulting permeability map defines and quantifies flow paths in the reservoir with the averaged permeability comparing favorably with the ground truth of permeability.
Reducing fear of water and aquaphobia through 360 degree video use?
Authors: Roche Lionel , Cunningham Ian , Rolland Cathy , Fayaubost Régis , Maire Sébastien
Published: November 2022

Drowning is a serious public health problem threat claiming the lives of 372,000 people each year worldwide that can be linked to an individual’s ability to swim. Learning to swim requires limited fear of water. This exploratory study investigated the potential interests of 360° video use for reducing fear and apprehension that underpin aquaphobia. Two students aged 11–12 years old who were non-swimmers with a reluctance to enter the water (i.e., a refusal and/or fear of immersion or to immerse only part of the face or the body in water) participated in qualitative interviews while viewing 360° video of an aquatic environment at progressively deeper levels through a head-mounted display (HMD). Three main findings were identified. First, the use of a 360° video viewed in an HMD led students to live an original corporeal immersive experience, a kind of immersion in the pool but experienced outside the pool. Second, students felt a strong emotional engagement between anxiety and curiosity from exploring the aquatic environment. Third, during the viewing situation, students developed and acquired accurate perceptive cues and knowledge related to the aquatic environment. The implications of these findings highlight the benefits of 360° video use as a tool to enhance greater confidence and familiarity with the aquatic environment to support learning and reduce phobia in non-swimmers. Limitations of the study and future research directions are discussed.
Evaluation of the efficacy of EU-TIRADS and ACR-TIRADS in risk stratification of pediatric patients with thyroid nodules
Authors: Tuli Gerdi , Munarin Jessica , Scollo Mariapia , Quaglino Francesco , De Sanctis Luisa
Published: November 2022

Background

Pediatric thyroid nodules have a lower prevalence but a higher rate of malignancy (ROM) than those in adults. Ultrasound features suspected of malignancy lead to fine needle aspiration biopsy (FNAB) and subsequent cytological determination, upon which management is decided. Based on the characteristics of ultrasound, to standardize clinician decisions and avoid unnecessary FNAB, the European Thyroid Association and the American Radiology College have established guidelines for Thyroid Imaging, Reporting and Data System (EU-TIRADS and ACR-TIRADS) for ROM stratification of thyroid nodules. The aim of this study is to evaluate the diagnostic performance of ACR-TIRADS and EU-TIRADS in pediatric age.

Materials and methods

Subjects younger than 18 years of age with thyroid nodules greater than 0.5 cm observed in the 2000-2020 period were included.

Results

Data from 200 subjects were collected. The overall ROM was 13%, rising to 26% if nodules with a diameter >1 cm were considered. Patients with a malignant nodule were more likely to have a higher EU-TIRADS score (p=0.03). Missed cancer diagnoses were 26.9%. Using the EU-TIRADS system, 40% of FNABs could have been avoided, while this scoring system would have resulted in FNAB being performed in 12% of cases where the assessment of ultrasound features would not recommend FNAB. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 73.1%, 57.1%, 73.1%, and 50%, respectively. Even considering the ACR-TIRADS, a higher score correlated with a higher ROM (p<0.001). This system missed 6 diagnoses of cancer (23.1%). Using the ACR-TIRADS system, 45.3% of FNABs could have been avoided, while FNAB should have been performed in 12% of cases where it was not recommended by ultrasound characteristics. Sensitivity, specificity, PPV and NPV were 76.9%, 50%, 76.9%, and 42.9%, respectively.

Conclusion

The present study confirms the correspondence of the EU-TIRADS and ACR-TIRADS categories with respect to malignancy but indicates not entirely satisfactory performance compared to FNAB alone. However, the use of the two TIRADS systems should be encouraged in multicentre studies to increase their performance and establish paediatric-specific points in the scoring criteria.
Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review
Authors: Osei Francis , Block Andrea , Wippert Pia-Maria
Published: November 2022

Allostatic load (AL) exposure may cause detrimental effects on the neuroendocrine system, leading to metabolic syndrome (MetS). The primary mediators of AL involve serum dehydroepiandrosterone sulfate (DHEAS; a functional HPA axis antagonist); further, cortisol, urinary norepinephrine (NE), and epinephrine (EPI) excretion levels (assessed within 12-h urine as a golden standard for the evaluation of the HPA axis activity and sympathetic nervous system activity). However, the evidence of an association between the primary mediators of AL and MetS is limited. This systematic review aimed to critically examine the association between the primary mediators of AL and MetS. PubMed and Web of Science were searched for articles from January 2010 to December 2021, published in English. The search strategy focused on cross-sectional and case–control studies comprising adult participants with MetS, obesity, overweight, and without chronic diseases. The STROBE checklist was used to assess study quality control. Of 770 studies, twenty-one studies with a total sample size (n = 10,666) met the eligibility criteria. Eighteen studies were cross-sectional, and three were case–control studies. The included studies had a completeness of reporting score of COR % = 87.0 ± 6.4%. It is to be noted, that cortisol as a primary mediator of AL showed an association with MetS in 50% (urinary cortisol), 40% (serum cortisol), 60% (salivary cortisol), and 100% (hair cortisol) of the studies. For DHEAS, it is to conclude that 60% of the studies showed an association with MetS. In contrast, urinary EPI and urinary NE had 100% no association with MetS. In summary, there is a tendency for the association between higher serum cortisol, salivary cortisol, urinary cortisol, hair cortisol, and lower levels of DHEAS with MetS. Future studies focusing on longitudinal data are warranted for clarification and understanding of the association between the primary mediators of AL and MetS.