bluuebunny/crossref_metadata_2025 huggingface dataset:
Larynx Angioedema as a Signal in Chronic Lymphocytic Leukemia: A Case-based Guide for Acquired Angioedema in the Setting of Lymphoproliferative Disorders
Authors: Kısakürek Zeynep Büşra , Sönmez Sadi Can , Osmanbaşoğlu Emre , Öztürk Erman , Öztürk Ayşe Bilge
Published: August 2021

ABSTRACT Patients with angioedema can present to the internal medicine, emergency medicine, dermatology, or ear nose throat clinics. Physicians may need to assess the patients whose angioedema is unresponsive to antihistamines systematically in collaboration with other subspecialties including hematology, rheumatology, allergy, and immunology. We aimed to provide a concise review of the diagnosis and multi-disciplinary management of acquired angioedema through a case presentation. A 61-year-old woman presented with recurrent angioedema of 4 episodes within one year. She was evaluated by various disciplines such as dermatology and emergency medicine. Antihistamines and steroids were not effective. The complete blood count (CBC) results indicated lymphocytosis (lymphocyte count=9100 k/μL) and further evaluation of the lymphocytosis with flow cytometry immunophenotyping confirmed a diagnosis of chronic lymphocytic leukemia. Since the acquired angioedema diagnosis was confirmed with low C4, C1q, and C1 esterase inhibitor levels, Rituximab 375 mg/m2 was administered once a week for 4 weeks. The frequency of attacks decreased after rituximab therapy and none of them were life-threatening. In conclusion, when the effective treatment is initiated for the primary diagnosis in acquired angioedema, the numerous emergency department visits, hospitalizations, and the mortality due to life-threatening angioedema episodes can be avoided. Keywords: Angioedema, larynx angioedema, emergency, chronic lymphocytic leukemia, life-threatening angioedema
Macrolide Allergy in Children and the Negative Predictive Value of Drug Provocation Tests in Mild Index Reactions
Authors: Karaatmaca Betül , büyük yaytokgil Şule , Külhaş Çelik İlknur , Yılmaz Topal Özge , Civelek Ersoy , Toran Müge , Dibek Mısırlıoğlu Emine
Published: August 2021

ABSTRACT Objective: Macrolide allergy is rarely reported, and there is limited knowledge of hypersensitivity reactions (HRs) in children. The negative predictive value (NPV) of drug provocation tests (DPTs) for macrolides is unresolved. We aim to evaluate the clinical features of macrolide allergy in children, and determine the NPV of macrolide DPTs. Materials and Methods: Pediatric patients who were referred to our allergy department with a suspicion of macrolide allergy were evaluated by DPTs with or without prior skin tests between 2011 and 2020. Characteristics of the HRs and patients, the results of skin and DPTs were recorded. At least three months after evaluation of the patients with allergy work up, telephone interviews were performed. Patients were asked whether they had reused the suspected macrolide or not. Patients who reported HR during subsequent drug intake were invited for reevaluation. Results: A total of 160 children (161 reactions) (55.6% male) with a suspicion of macrolide allergy were enrolled for the study, and all children had a mild index reaction. The median age was 48 (18-102) months, and the median time between the suspected allergic reaction and allergy work-up was 3 (2-8) months. The most frequently reported suspected agent was clarithromycin, in 151 patients (94.4%). Macrolide allergy was confirmed in 8 (5%) patients. Only one patient reported skin eruptions upon reuse despite a negative DPT and he was invited to be reevaluated. A second DPT was performed resulting in urticarial lesions. The NPV was found to be 97.4% for negative DPT with macrolides. Conclusion: Confirmed macrolide allergy is rare in children, and DPTs are the gold standard to assess suspected macrolide allergy. The NPV of macrolide provocation tests seems to be high in children. Keywords: Children, drug hypersensitivity, drug provocation test, macrolide, negative predictive value
Global Civil Society and its Role in Democracy and Good Governance Issues
Authors: Faraj Anwar M. , Ahmad Narmin Husain
Published: August 2021

This research sought to know the role of global civil society organizations in democracy and good governance issues, and it found that despite the fact that these two issues are at the core of internal affairs and national sovereignty, the global civil society has found legitimacy for it in practicing its role, in order to enhance these two values. The research pointed to the most important criticisms directed to the performance of global civil society organizations in both issues of democracy and good governance.
The Entrepreneurial Ecosystem and the role of universities to activating it, Sulaymaniyah Governorate as a case study
Authors: Muhammad Farooq , Mahmood Faraydoon Mohammad , Abdallah Ilham Abdul-Rahman
Published: August 2021

The entrepreneurship ecosystem is a special system of relevant stakeholders that support and contribute directly or indirectly to assist entrepreneurs to launch their businesses and projects. Human capital is one of the essential components of the entrepreneurs' ecosystem on which the success of entrepreneurship depends. This research investigated the importance of the entrepreneurship ecosystem and the role of universities in activating it. Unemployment is one of the biggest a growing challenges for Iraq and the Kurdistan Region in light of the large growth rate of the population and the slow growth of the economy, which has created countless problems. This challenge must be faced by all possible means. Activating the entrepreneurship ecosystem is a proven and successful method for the natural birth and growth of businesses and projects, creating job opportunities, and reducing unemployment. The province of Sulaymaniyah was chosen as the limits of the spatial research and the temporal boundary is between the beginning of the first month and until the sixth month of 2021 within the period of the outbreak of the Covid19 epidemic. The research population is university graduates in recent years, and the research sample was 92 university graduates from various disciplines, of both sexes, and within one age category (23-26 years). The research found that most university graduates have some basic skills for business management, but before establishing their businesses, they need additional doses of skills designed through the curricula established in universities, and there were no statistically significant differences due to the gender variable in the level of their entrepreneurial abilities. It is expected that the conclusions and recommendations reached by this research will be a reference for university curricula and syllabus designers, decision-makers, and researchers for solutions to the unemployment crisis in Iraq and the Kurdistan Region.
Predicting Prolonged Apnea During Nurse-Administered Procedural Sedation: Machine Learning Study
Authors: Conway Aaron , Jungquist Carla R , Chang Kristina , Kamboj Navpreet , Sutherland Joanna , Mafeld Sebastian , Parotto Matteo
Published: August 2021

Background

Capnography is commonly used for nurse-administered procedural sedation. Distinguishing between capnography waveform abnormalities that signal the need for clinical intervention for an event and those that do not indicate the need for intervention is essential for the successful implementation of this technology into practice. It is possible that capnography alarm management may be improved by using machine learning to create a “smart alarm” that can alert clinicians to apneic events that are predicted to be prolonged.

Objective

To determine the accuracy of machine learning models for predicting at the 15-second time point if apnea will be prolonged (ie, apnea that persists for >30 seconds).

Methods

A secondary analysis of an observational study was conducted. We selected several candidate models to evaluate, including a random forest model, generalized linear model (logistic regression), least absolute shrinkage and selection operator regression, ridge regression, and the XGBoost model. Out-of-sample accuracy of the models was calculated using 10-fold cross-validation. The net benefit decision analytic measure was used to assist with deciding whether using the models in practice would lead to better outcomes on average than using the current default capnography alarm management strategies. The default strategies are the aggressive approach, in which an alarm is triggered after brief periods of apnea (typically 15 seconds) and the conservative approach, in which an alarm is triggered for only prolonged periods of apnea (typically >30 seconds).

Results

A total of 384 apneic events longer than 15 seconds were observed in 61 of the 102 patients (59.8%) who participated in the observational study. Nearly half of the apneic events (180/384, 46.9%) were prolonged. The random forest model performed the best in terms of discrimination (area under the receiver operating characteristic curve 0.66) and calibration. The net benefit associated with the random forest model exceeded that associated with the aggressive strategy but was lower than that associated with the conservative strategy.

Conclusions

Decision curve analysis indicated that using a random forest model would lead to a better outcome for capnography alarm management than using an aggressive strategy in which alarms are triggered after 15 seconds of apnea. The model would not be superior to the conservative strategy in which alarms are only triggered after 30 seconds.
Ganancia educativa en la educación media superior
Authors:   El Colegio de México, Tuirán Rodolfo , Gaviria-Soto José Luis ,   Universidad Complutense de Madrid, Lugo-Campos Rubén ,   Centro Nacional de Evaluación para la Educación Superior, Hernández-Franco Daniel ,   Tecnológico de Monterrey, Benítez-Isidoro Miriam ,   Emerging Markets Political Risk Analysis
Published: August 2021

Se presentan los resultados del primer estudio a nivel nacional en México de la ganancia educativa de los alumnos de tres generaciones, quienes concluyeron su educación media superior a partir de 2013. Se analizan datos de pruebas estandarizadas ENLACE de tercero de secundaria y de ENLACE/PLANEA de tercer grado de bachillerato, a través de reactivos ancla que midieran constructos semejantes en dos momentos en el tiempo para los mismos estudiantes. La comparación de medias de habilidad en los dos momentos de evaluación permite identificar que hay avance en el rendimiento de los alumnos al concluir el bachillerato, independientemente de la institución, algunas características individuales y el lugar donde se ubique la escuela. Se presentan análisis bivariados y multivariados, identificando diferencias en la ganancia educativa de acuerdo con el subsistema de educación media superior en que se estudió, turno al que asistió, tipo de secundaria del que provinieron y sexo de los estudiantes, entre otras variables.
Hombres en profesiones de cuidado tradicionalmente feminizadas
Authors:   El Colegio de México, Figueroa Juan Guillermo
Published: August 2021

Este texto busca documentar las experiencias de algunos varones en profesiones feminizadas. Se plantean tres ejes de análisis: a) la llegada, expectativas y salida de las profesiones feminizadas, b) ventajas y desventajas dentro de la profesión y c) experiencias de cuidado más allá de su profesión. Se recurre a entrevistas a profundidad a siete varones. Destaca que los varones llegan a las profesiones por una mezcla de expectativas económicas y de desarrollo personal. Reportan discriminación de mujeres adultas mayores (entre los enfermeros) y de otros varones en su pro-fesión (entre los profesores). En el ámbito doméstico llevan a cabo actividades de cuidado de sus hijos y padres. Se concluye con una ruta de temas a profundizar.
Apertura hacia la anticoncepción adolescente entre los padres y las madres en México: un estudio de caso desde la sociodemografía
Authors:   San Diego State University, Ojeda de la Peña Norma , González-Ramírez Raúl S. ,   El Colegio de la Frontera, Ramos-Vargas Alina ,   Universidad Autónoma de Baja California
Published: August 2021

Se analizan las actitudes de los padres y madres respecto de la sexualidad y la anticoncepción adolescente en México, mediante el caso de Tijuana, B.C. Se examinan los niveles de apertura de los padres de ambos sexos en favor de proporcionar información al respecto a los adolescentes de ambos sexos. Este es un estudio socio-demográfico y de tipo descriptivo basado en informa-ción de una encuesta a 2,547 padres y madres con hijos en escuelas secundarias públicas. Los resultados indican interesantes diferencias de género significativas, donde las madres presentan índices de apertura mayores que los padres. Otras variables significativas son la escolaridad y el tener antecedentes de maternidad adolescente en la historia reproductiva de las madres y de las esposas o compañeras de los padres varones.
Critical review of the article “Effect of Low Hydroxyapatite Loading Fraction on the Mechanical and Tribological Characteristics of Poly (Methyl Methacrylate) Nanocomposites for Dentures”
Authors: Campos Sanabria Virginia , Moreno Bello Karla Judith
Published: August 2021

The study of new materials for biomedical application is still in the focus of scientific researchers because materials that satisfy completely biological needs have not been found yet. The recent investigation of Ahmed Fouly et al., (2021) addresses the analysis of a nanocomposite broadly employed as denture base material: the poly (methyl methacrylate) (PMMA) reinforced with Hydroxyapatite (HA). The relevance of the research lies in the need of enhancing the mechanical and tribological composite properties to decrease material failures, disturbing of patients, as well as cost and duration of treatments. In this scenario, the authors evaluated PMMA/HA nanocomposites with different low loading fractions of HA and related the effect of those concentrations on the change in the specified properties.
Greeting Card app based on Augmented Reality
Authors: Pacherkar Bhagyashri
Published: August 2021

Abstract: Augmented Reality is a combination of a real and a computer-generated or virtual world. It is achieved by augmenting computer-generated images on real world. It is of four types namely marker based, marker less, projection based and superimposition based augmented reality. It has many applications in the real world. AR is used in various fields such as medical, education, manufacturing, robotics and entertainment. Augmented reality comes under the field of mixed reality. It can be considered as an inverse reflection of Virtual Reality. They both have certain similarities and differences. This paper gives information about Augmented Reality and how it started. It analyses various types of augmented reality, its applications and its advantages and disadvantages. This paper also gives us knowledge regarding those major threats that augmented reality will face in the near future and about its current and future applications. It gives us a comparison between the two related topics, Augmented reality and Virtual reality. The following paper also helps us know about the effect of Augmented Reality on the human life.
Observations on Antagonism in the Arbuscular Mycorrhizal Systems
Authors: Abourghiba Taher Y.
Published: August 2021

Abstract: The majority of land plants are colonised by arbuscular mycorrhizal fungi, however ,members of few families notably Cruciferae, Chenopodiaceae, Caryophyllaceae and Polygonaceae, so called non-host are not colonized by these fungi. Previous studies have shown that the growth and development of non-host species were severely inhibited when grown in the presence of active AMF mycelia. There is therefore a need to understand the mechanistic bases of adverse effects of AMF mycelia upon seedlings of non-host species. In this experiment young roots of non-hosts Spergula arvensis and Arabis hirsuta, and host Centaurium erythraea were exposed to mycorrhizal and non-mycorrhizal extracts. The results of this experiment showed that mycorrhizal extracts significantly reduced the growth of radicles and root hairs development of non-host species whereas had no effect on radicles and root hairs development of host species. These results indicate that toxicity effects rather the nutritional factors are the drivers of the negative responses of non-host species to the presence of the AMF. Keywords: mycorrhizal fungi, host and non-host plants, Plantago lanceolata , Glomus mossae , mycelium
Python the game changer in the field of Machine Learning, Data Science and IoT: A Review
Authors: Parial Prithwish
Published: August 2021

Abstract: Python is the finest, easily adoptable object-oriented programming language developed by Guido van Rossum, and first released on February 20, 1991 It is a powerful high-level language in the recent software world. In this paper, our discussion will be an introduction to the various Python tools applicable for Machine learning techniques, Data Science and IoT. Then describe the packages that are in demand of Data science and Machine learning communities, for example- Pandas, SciPy, TensorFlow, Theano, Matplotlib, etc. After that, we will move to show the significance of python for building IoT applications. We will share different codes throughout an example. To assistance, the learning experience, execute the following examples contained in this paper interactively using the Jupiter notebooks. Keywords: Machine learning, Real world programming, Data Science, IOT, Tools, Different packages, Languages- Python.
Numerical Analysis of Semi-Tangential Ogive Bullet
Authors: T Avinash
Published: August 2021

Abstract: The objective of the present study is to design and analyze semi-tangential ogive bullets using simulatation software such as Computer-aided design & Computational Fluid Dynamics (CFD). It is observed that been a quite steady increase in the bullet research design in the past few decades. The nose section of ballistic bullet is the most important part of the design process. Hence design optimizations are achieved by adjusting the bullet's form to improve precision and stability by reducing its drag force. CFD is the study used to verify the findings. Since provides most accurate results. It is observed that present study optimizes the behavior of the at M= 2.5. This present work shows the flow of air around the bullet surface providing pressure & velocity contours at every segment. The Various parametric studies over bullet model are drag co-efficient, ballistic coefficient and turbulence viscosity are plotted’.
Insights of the Olympics: Athens to Rio
Authors: Patel Rakshit
Published: August 2021

Abstract: The Olympics is one of the eye-catching platforms for the sports community as well as sports’ lovers in the 21st Century. Sports also adopted the marvelous advancements that took place in vivid fields of technologies. In this modern era of analytics, every category demands prior research before indulging in the actual event. The sports analysis is the primary focus of this paper which mainly displays analysis of comprehensive data about different sport events involved in Olympics taking place from its beginning to the year 2016. The changing time brings new challenges and understanding the tactics along with the playing style of the opponent has become a necessity which basically constitutes to sports analytics. The analysis of the Olympics revealed certain riveting and fascinating facts referring to different aspects and areas. Numerous captivating results can be observed after carrying out research and analysis over the dataset of the Olympics. The analysis implies survey of age wise distribution of the competitors along with the winners' age classification. The medals tally list of countries with respective medals won till Rio Olympics is displayed and studied. In addition, the different venues which hosted the Olympics along with their respective year and number of participants is listed. The competitors with highest numbers of medals also contribute to our research's aim. The Indian Olympic medalists are also focused keeping their participation and winning ratio in consideration. With our research, we would like to light up unexposed and unexplored gospel. Keywords: Statistical Data, Sports Analytics, Data visualization, Factors, The Olympics
The Relevance of Defined Daily Dose concept in Drug Utilisation Research: A Review
Authors: Baiju Agnus , Jacob Rosmin , Krishnakumar K.
Published: August 2021

According to World Health Organisation (WHO), drug utilisation is defined as the marketing, distribution, prescription and the use of drugs in society with special focus on resulting medical, social and economic consequences and it has turned into a powerful scientific tool for ensuring the rational and cost-effective use of drugs. A standard method is required to identify and aggregate drug data. This manuscript provides an overview of the WHO Anatomical Therapeutic Chemical (ATC) classification and the associated measure, Defined Daily Dose (DDD), as a methodology for evaluating drug utilisation.

Keywords: Drug utilisation research, Anatomical Therapeutic Chemical classification system, Defined Daily Dose, Rational drug use.
A Review on Modern Use of Intranasal Vaccination in the Treatment of SARS-COV-2
Authors: Shah Saumi Saurin , Patel Charmi Mahendrakumar , Patel Dhrumi Hiteshbhai , Vadgama Prapti Hiteshkumar , Patel Manan , Trivedi Riddhi
Published: August 2021

The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for efficient SARS coronavirus 2 (SARS-CoV-2) preventative vaccines to limit the burden and spread of SARS-CoV-2 in humans. Intranasal immunization is a promising technique for preventing COVID-19 because the nasal mucosa acts as a first line of defense against SARS-CoV-2 entrance before the virus spreads to the lungs. Nasal vaccination has many advantages over traditional vaccine administration methods. These include the simplicity of administration without the use of needles, which decreases the risks of needle stick injuries and disposal. This channel also provides simple access to a crucial portion of the immune system that can stimulate other mucosal sites throughout the body. By targeting immunoglobulin A (IgA), antibodies found only in the mucosa, an intranasal vaccination would elicit immunological responses in the nose, throat, and lungs. Potential pathogens are trapped by the mucosa, which acts as a physical barrier to prevent them from entering the body. Given this, the intranasal vaccine would prevent virus transmission via exhaled droplets or aerosols because there would be no virus in the body to expel .There are several intranasal vaccines for protection against sars-cov2 are under preclinical and clinical trials .The key challenge is in Designing delivery strategies that take into account the wide range of diseases, populations, and healthcare delivery settings that stand to benefit from this unique mucosal route should be prioritized.

Keywords: COVID-19, Intranasal vaccine, Immunoglobulin A, Permeation
The Role of Clinical Pharmacist in Enhancement of Medication Adherence and Quality of Life in Bronchial Asthma and Chronic Obstructive Pulmonary Disease
Authors: Gangadharan Aswathi , Thomas Diya Sheela , Harshida , , Tom Cyril , Adake Prabhakar
Published: August 2021

Asthma and Chronic Obstructive Pulmonary Disease (COPD) are two of the leading causes of morbidity, mortality and economic burden worldwide. The burden of chronic respiratory disease has major adverse effects on the quality of life and ability of affected individuals. A variety of effective treatment options exist for patients with Asthma and COPD but long-term adherence to medications is required for treatment success. Aim of the study was to assess the adherence to medication and quality of life in Asthma and COPD patients using questionnaires, and to enhance adherence and quality of life using the strategies of counselling and education. The observational study was conducted for a period of 6 months, assessed medication adherence by Morisky self-reported questionnaires and quality of life by St. George’s Respiratory questionnaire (SGRQ) and 36 item short form health survey (SF-36). The study shows there was statistically significant improvement in medication adherence score (p<0.05) and quality of life (p<0.05) after pharmacist’s counselling regarding disease, medication and lifestyle. Comparison between various demographic factors like age, gender, co-morbidities, smoking index showed equal impact of pharmacist’s counselling on improvement of overall medication adherence and quality of life in Asthma and COPD patients. Overall medication adherence and quality of life improvement was found to be statistically significant in Asthma and COPD patients after counselling by clinical pharmacists. Clinical pharmacists must be considered as an integral element of healthcare system. Patient counselling is effective to resolve the problems associated with medication non-adherence and quality of life.

Keywords: Asthma, COPD, Medication adherence, Quality of life
Formulation and Evaluation of Lamivudine Nanosuspension
Authors: Ramesh Yerikala , Sarayu Ballem , Hari Chandana Guduru , Neelima Obili , Sana Shaik
Published: August 2021

The present research aimed to develop & Evaluation of Lamivudine Nanosuspension. Lamivudine is a potent in vitro inhibitor of human immune deficiency virus belongs to the category of anti-retroviral drugs. The formulated Nanosuspension was subjected to various evaluation parameters like particle size, polydispersity index, zeta potential, drug content, viscosity, saturation solubility studies, In vitro release, treatment of kinetic data, and stability studies. The polydispersity ranged from 0.218 PDI to 0.331 PDI and zeta potential ranged from -1.60 mV to -4.79 mV are the important evaluation parameters are responsible for the stability of nanosuspensions. The Polydispersity index presents the quantity of particle size distribution ranges from 452.4 nm to 532.2 nm. In this result, LNSF4 shows spectacular drug content range of 86±1.8% to 97±2.5% it is the maximum drug content. The Brook field viscometer to determine the viscosity of Lamivudine Nano suspension of different formulations was found to be 44.4±2.1 cps to 87.7±1.4 cps. The general Nanosuspension formulations LNSF4 shows 98.64 % better controlled released in comparison with abundant formulation. In all the cases the best-fit model encounter uoto be peppas with ‘n’ value between 0.768 to 0.917. The ‘n’ value of formulation LNSF4 was 0.876 and suggesting so the drug was released by Zero-order kinetics. Acceleration stability studies intermediate storage condition has been changed from 30°C ± 2°C and 60% RH ± 5% Relative Humidity. After a 90 days study it revolves that there’s no change in Drug content, In vitro drug release, and particle size.

Keywords: Lamivudine, Nanosuspension, Saturation solubility, Scanning Electron Microscopy, Stability study.
Pharmacological evaluation for Anti-Anxiety and CNS depressant activity of hydro-alcoholic leaves extract of Pongamia pinnata
Authors: Panda Jagannath , Samantaray Biswajit , Pattnaik Gurudutta
Published: August 2021

The aim of this study was to assess the anti-anxiety and CNS depressant properties of hydro-alcoholic extract of Pongamia pinnata leaves (HALEPP). Standard methods were used to screen the HALEPP's phytochemicals, which showed that the extract contains Flavones, alkaloids, glycosides, proteins and amino acids, gum and mucilage as well as flavonoids, saponins, and steroid hormones. Even at the dose level of 1000 mg/kg body weight, the HALEPP showed no signs of toxicity or mortality in the acute toxicity report. The anti-anxiety behaviour of was studied using light and dark model methods in rats. The CNS depressant action was studied using the extract and actophotometer (Rolex) in rats. The research group (HALEPP 200 gm/kg treated) animals displayed strong anti-anxiety and CNS depressant behaviour similar to the control group (diazepam treated) animals in the current study. The study's findings suggest that the hydro-alcoholic Pongamia pinnata leaf extract has strong anti-anxiety and CNS depressant properties.

Keywords: Pongamia pinnata, Anti-Anxiety & CNS depressant
Content Validity Determination of the Suicidal Ideation Behaviour Assessment Instruments Using Content Validity Ratio (CVR) Formula
Authors: Norshahira Osman , Norashida S. R., , Lukman Z. M.
Published: August 2021

Drug addiction problems have been identified as one of the high-risk factors closely linked to suicidal behaviour. Early detection of suicidal intent among addicts is important to ensure they do not take actions that could result in death. Accordingly, this study aimed to Suicidal Ideation Behaviour Assessment (SIBA) instruments specifically among 123 treated addicts in Cure and Care Rehabilitation Centre (CCRC), Besut. Based on those statements, the main objective of this study was to determine the content validity of SIBA instruments for using the content validation Ratio (CVR) method. Subjects that were involved in conducting the trial of the instruments were 8 experts from UniSZA, UPSI and UMT. The instrument validation process involved 40 items from four components. The previous study found that the instrument had high validity with the minimum level of CVR value (N=8, CVR = 0.88). Generally, all items were identified with values above 0.63 rated acceptable and no item has been rejected occur. The result showed that the instrument is appropriate, relevant, has the potential to be a good content validity and proved that SIBA has a great potential to be promoted as a good instrument. This study was conducted to detect intoxication of their suicidal ideation among drug addicts. This psychometric instrument is developed based on the situation in Malaysia. This study is expected to make a significant contribution to the government, especially the CCRC in assisting addicts with suicidal ideation behaviour by providing better attention and psychosocial support services.

Keywords: Suicide ideation, drug addict, content validity ratio, instrument
The Relationship of Knowledge, Attitudes, and Practices of Fe Tablet Consumption of Mothers with Toddlers with Stunting Incidences in Cilembu Village, Sumedang Regency in 2019
Authors: Suryanegara Wiradi , Wija Ida Bagus Eka Utama
Published: August 2021

Figures stunting in Indonesia did not experience a significant decline in 2007, 2010, and 2013. Where in 2007, the figure stunting in Indonesia is 36.8%. Whereas in 2010 and 2013, each of which has a percentage of 35.6% and 37.2%. Riskesdas in 2013 researched and found that the incidence of anaemia in pregnant women is at 37.1%, and in 2018 the prevalence of anaemia in the pregnant women group increased to 48.9%. This study aims to determine the relationship between Fe tablet consumption's knowledge, attitudes, and practices in mothers with toddlers with stunting incidents in Cilembu village, Sumedang district, in 2019. The method used is the analytic study of cross pieces (cross-sectional). The number of samples in this study was 45 respondents taken by non-random sampling with the purposive sampling method. Based on the data analysis, no relationship between knowledge, attitudes, and practices of Fe tablet consumption in mothers with toddlers with stunting incidents in Cilembu village, Sumedang district in 2019 (p value> 0.05). There is no relationship between Fe tablet consumption knowledge, attitudes, and practices in mothers with toddlers with stunting incidents in Cilembu village, Sumedang district in 2019.

Keywords: Knowledge, Attitude, Practice, Tablet Fe, Stunting
Legal aspects of environmental safety in the field of medical waste management in the context of the pandemic
Authors: Alekseeva Nadezhda A.
Published: August 2021

Medical waste management has always been relevant from a practical point of view, but as a result of the pandemic declared in 2020, this topic has multiplied, leading to significant changes in the legal regulation of medical waste. The realization that re-contamination from medical covid-waste is possible led to the obligation to install disinfectants in medical and pharmacological organizations. The division of medical waste into classes predetermined the assignment of medical covid-waste to class B, and after disinfection - to A-class, that are possible to transport and dispose after disinfection. However, there is a huge amount of covid-waste outside medical and pharmacological organizations, which is, clearly, are not medical. When mixed with solid household waste and garbage that does not require a transport licence, it increases the likelihood of re-infection of those who handle such waste. The object of the work is to explore these topics and to raise the issue of separation of the accumulation and disposal of non-medical covid-waste in legal regulation, as well as the ways to implement them. Related to this is the issue of environmental pollution in the context of the pandemic, because non-medical covid-waste has increased the amount of plastic that pollutes the environment.
Penerapan Vector Autoregressive Integrated (VARI) Pada Data Jumlah Peserta KB Aktif
Authors: Sihombing P R , Yulianti I F , Istinah A N
Published: August 2021

Program KKBPK merupakan salah satu upaya yang telah dilakukan oleh pemerintah melalui Badan Kependudukan dan Keluarga Berencana Nasional (BKKBN) dalam menangani masalah kependudukan terutama dalam aspek kuantitas, yaitu dengan mengendalikan jumlah penduduk melalui penurunan fertilitas. Kab. Garut dan Kab. Bandung menjadi prioritas dalam rangka pengendalian fertilitas dipantau melalui perkembangan peserta KB aktif karena dianggap dapat memberikan sumbangan yang besar dalam menurunkan TFR dan meningkatkan Contraceptive Prevelance Rate (CPR) di Provinsi Jawa Barat. Penelitian ini menerapkan VARI dalam pemodelan peserta KB aktif pada Kab. Bandung dan Kab. Garut. Dua persamaan diatas menunjukkan bahwa variabel yang diamati, yaitu jumlah peserta KB aktif di Kab. Garut dan Kab. Bandung, saling mempengaruhi satu sama lain. Jumlah peserta KB aktif di Kab. Garut dipengaruhi oleh jumlah peserta KB aktif di Kab. Garut pada satu periode sebelumnya dan oleh jumlah peserta KB aktif di Kab. Bandung satu periode sebelumnya. Dengan demikian, Jumlah peserta KB aktif di Kab. Bandung dipengaruhi oleh jumlah peserta KB aktif di Kab. Bandung pada satu periode sebelumnya dan oleh jumlah peserta KB aktif di Kab. Garut satu periode sebelumnya.
Optimasi Hasil Produksi Olahan Daging Sapi Dengan Menggunakan Linear Programming (Studi Kasus : UD. Angkasa Timor Kupang)
Authors: Adoe V S
Published: August 2021

ABSTRACTUD. Angkasa Timor is one of the business units engaged in beef processing with 3 forms of products produced, se'i, beef jerky and shredded beef. The obstacle faced is that entrepreneurs have not used the available resources optimally so the benefits have not been maximized. Therefore, this study aims to combine existing production resources so that entrepreneurs can obtain optimal production results and can obtain maximum profits. By using linear programming methods in the POM-QM For Windows V4 application, the analysis results are obtained X1 = 0.8571 kg, X2 = 1.8033 kg, and X3 = 0.2459 kg, with an Z value or an optimal profit of Rp. 7,197,893, Keywords : Linear Programming, Optimization
Analisis Kelainan Jantung Menggunakan Dimensi Fraktal Dan Transformasi Wavelet
Authors: Oktaviani D R , Habiburrohman M
Published: August 2021

ABSTRACT

The disease that causes the largest number of deaths in Indonesia to date is acute coronary syndrome or called the silence killer. Deaths due to coronary heart disease (CHD) reached 26.4%. Therefore, to prevent the high death rate from CHD, early detection of CHD can be done. One way that can be done is checking the ECG (electrocardiogram / electrocardiograph) record. Then by using the HRV (Heart Rate Variability) method, which is to analyze the ECG signal which can take measurements, physiological interpretation, and clinical use of the ECG signal so that it can find out an arrhythmia (a condition in which the heart beats erratically) a person's heart and take medical steps right. In this article using wavelet transform analysis to identify heart disease. The results are then compared with the fractal dimensions of the heart rate signal. FD identifies heart disease with more than 90% confidence

Keywords      : Fractal, Heart, Wavelet.
Prediksi Jumlah Mahasiswa Baru Menggunakan Metode Regresi Linier Sederhana
Authors: Almumtazah N , Azizah N , Putri Y L , Novitasari D C R
Published: August 2021

Jumlah mahasiswa baru suatu universitas selama 5 tahun terakhir yaitu mulai tahun 2016 hingga tahun 2020 mengalami kenaikan dan penurunan. Data tersebut selanjutnya akan digunakan untuk memprediksi pada tahun mendatang. Tujuan dibuat sebuah prediksi adalah untuk mengetahui rasio dosen yang tersedia dengan jumlah mahasiswa baru, mempersiapkan ruang kuliah dan juga fasilitas lainnya. Salah satu metode dengan penggunaan data masa lampau untuk melakukan prediksi adalah dengan metode regresi linier. Pada penelitian ini yang menjadi variabel bebas adalah periode tahun akademik sedangkan yang menjadi variabel terikat adalah jumlah mahasiswa baru. Data yang akan digunakan merupakan data mahasiswa baru fakultas sains dan teknologi yang terdiri dari 6 program studi dengan nilai MAPE (Mean Absolute Percentage Error) yaitu matematika , ilmu kelautan , biologi , sistem informasi , arsitektur , dan teknik lingkungan . Berdasarkan hasil analisis data tersebut juga didapatkan prediksi jumlah mahasiswa baru 5 tahun kedepan dengan hasil cenderung turun untuk setiap program studi.
Dua Formula Eksponensial (Operator Linear dari Semigrup)
Authors: Meisaroh L
Published: August 2021

Assumed A is infinitesimal generator of C0-semigroup T(t) on X. This could be defined as T(t)=etA, applies if A is a bounded linear operator. Not if A is unbounded linear operator, then it will result in one possibility that show T(t) could be represented as etA. This paper will discuss and detail the proof of the other two formulas that show T(t) could be represented as etA.
The Urgency of Village Mediation Institution as a Mechanism for Dispute Resolution: The Case of Wukirsari Village in the Special Region of Yogyakarta
Authors: Isdiyanto Ilham Yuli , Wahyu Asmorojati Anom
Published: August 2021

This research discusses an important issue in the rural administration, that is the urgency of institution transformation of the status and position of the Village Head in dispute resolution among villagers. The purpose of this research is to highlight the urgency of institutionalization of dispute resolution through the Village Mediation Institution. The first concern is to find the status and legal basis of the Institution; the second is to describe the urgency of establishing this institution as a dispute resolution mechanism among villagers; and the third is to build the model or system that matches with the condition in Wukirsari. The research method used was a normative-empirical-concept and the data were analyzed qualitatively to be presented as a descriptive-prescriptive analysis. The result of this research shows that there is an urgency for Wukirsari Village government to form a Village Mediation Institution due to socio-geographic considerations and also as an implementation of Article 26 paragraph (4) letter K of Village Law No. 6 of 2014. The Village Mediation Institution in Wukirsari Village should consist of a balance composition between the elements of Village Government and professionals so that it will become an effective and efficient institution in resolving disputes among the members of Wukirsari Village society.
Investigation of the impact of mechanical activation on synthesis of the MgO-TiO2 system
Authors: Djordjevic Natasa , Vlahovic Milica , Martinovic Sanja , Mihajlovic Slavica , Vusovic Nenad , Sokic Miroslav
Published: August 2021

In this study, a mixture of magnesium oxide and titanium dioxide was mechanically activated in order to investigate the possibility of mechanochemical synthesis of magnesium titanate. Mechanical activation was performed for 1000 min in a high-energy vibro mill (type MH954/3, KHD Humboldt Wedag AG, Germany). The mill is equipped with housing having a horizontally placed shutter. The cylindrical stainless steel working vessel, with inner dimensions of 40 mm in height and 170 mm in diameter, has working elements consisting of two free concentric stainless steel rings with a total weight of 3 kg. The engine power is 0.8 kW. Respecting the optimal amount of powder to be activated of 50-150 g and the stoichiometric ratio of the reactants in the equation presenting the chemical reaction of magnesium titanate synthesis, the starting amounts were 20.2 g (0.5 mol) of MgO and 39.9 g (0.5 mol) TiO2. During the experiments, X-ray diffraction analysis of the samples taken from the reaction system after 60, 180, 330, and 1000 min of mechanical activation was performed. Atomic absorption spectrophotometry was used for chemical composition analysis of samples taken at different activation times. Based on the X-ray diffraction analysis results, it can be concluded that the greatest changes in the system took place at the very beginning of the mechanical activation due to the disturbance of the crystal structure of the initial components. X-ray diffraction analysis of the sample after 1000 min of activation showed complete amorphization of the mixture, but diffraction maxima characteristic for magnesium titanate were not identified. Therefore, the mechanical activation experiments were stopped. Evidently, the energy input was not sufficient to overcome the energy barrier to form a new chemical compound - magnesium titanate. The failure to synthesize magnesium titanate is explained by the low negative Gibbs energy value of -25.8 kJ/mol (despite the theoretical possibility that the reaction will happen), as well as by the amount of mechanical energy entered into the system during activation which was insufficient to obtain the reaction product. Although the synthesis of MgTiO3 was not achieved, significant results were obtained which identify models for further investigations of the possibility of mechanochemical reactions of alkaline earth metals and titanium dioxide.
Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region
Authors: Bowker Nicholas , Hansford Robert , Burgess Stephen , Foley Christopher N. , Auyeung Victoria P.W. , Erzurumluoglu A. Mesut , Stewart Isobel D. , Wheeler Eleanor , Pietzner Maik , Gribble Fiona , Reimann Frank , Bhatnagar Pallav , Coghlan Matthew P. , Wareham Nicholas J. , Langenberg Claudia
Published: August 2021

There is considerable interest in GIPR agonism to enhance the insulinotropic and extrapancreatic effects of GIP, thereby improving glycemic and weight control in type 2 diabetes (T2D) and obesity. Recent genetic epidemiological evidence has implicated higher GIPR-mediated GIP levels in raising coronary artery disease (CAD) risk, a potential safety concern for GIPR agonism. We therefore aimed to quantitatively assess whether the association between higher GIPR-mediated fasting GIP levels and CAD risk is mediated via GIPR or is instead the result of linkage disequilibrium (LD) confounding between variants at the GIPR locus. Using Bayesian multitrait colocalization, we identified a GIPR missense variant, rs1800437 (G allele; E354), as the putatively causal variant shared among fasting GIP levels, glycemic traits, and adiposity-related traits (posterior probability for colocalization [PPcoloc] > 0.97; PP explained by the candidate variant [PPexplained] = 1) that was independent from a cluster of CAD and lipid traits driven by a known missense variant in APOE (rs7412; distance to E354 ∼770 Kb; R2 with E354 = 0.004; PPcoloc > 0.99; PPexplained = 1). Further, conditioning the association between E354 and CAD on the residual LD with rs7412, we observed slight attenuation in association, but it remained significant (odds ratio [OR] per copy of E354 after adjustment 1.03; 95% CI 1.02, 1.04; P = 0.003). Instead, E354’s association with CAD was completely attenuated when conditioning on an additional established CAD signal, rs1964272 (R2 with E354 = 0.27), an intronic variant in SNRPD2 (OR for E354 after adjustment for rs1964272: 1.01; 95% CI 0.99, 1.03; P = 0.06). We demonstrate that associations with GIP and anthropometric and glycemic traits are driven by genetic signals distinct from those driving CAD and lipid traits in the GIPR region and that higher E354-mediated fasting GIP levels are not associated with CAD risk. These findings provide evidence that the inclusion of GIPR agonism in dual GIPR/GLP1R agonists could potentiate the protective effect of GLP-1 agonists on diabetes without undue CAD risk, an aspect that has yet to be assessed in clinical trials.
Low Plasma Adiponectin in Risk of Type 2 Diabetes: Observational Analysis and One- and Two-Sample Mendelian Randomization Analyses in 756,219 Individuals
Authors: Nielsen Maria B. , Çolak Yunus , Benn Marianne , Nordestgaard Børge G.
Published: August 2021

We tested the hypothesis that low plasma adiponectin is associated observationally and causally with increased risk of type 2 diabetes. Observational analyses are prone to confounding and reverse causation, while genetic Mendelian randomization (MR) analyses are much less influenced by these biases. We examined 30,045 individuals from the Copenhagen General Population Study observationally (plasma adiponectin [1,751 individuals with type 2 diabetes]), 96,903 Copenhagen individuals using one-sample MR (5 genetic variants [5,012 individuals with type 2 diabetes]), and 659,316 Europeans (ADIPOGen, GERA, DIAGRAM, UK Biobank) using two-sample MR (10 genetic variants [62,892 individuals type 2 diabetes]). Observationally, and in comparisons with individuals with median plasma adiponectin of 28.9 μg/mL (4th quartile), multivariable adjusted hazard ratios (HRs) for type 2 diabetes were 1.42 (95% CI 1.18–1.72) for 19.2 μg/mL (3rd quartile), 2.21 (1.84–2.66) for 13.9 μg/mL (2nd quartile), and 4.05 (3.38–4.86) for 9.2 μg/mL (1st quartile). Corresponding cumulative incidence for type 2 diabetes at age 70 years was 3%, 7%, 11%, and 20%, respectively. A 1 μg/mL lower plasma adiponectin conferred an HR for type 2 diabetes of 1.07 (1.06–1.09), while genetic, causal risk ratio per 1 unit log-transformed lower plasma adiponectin was 1.13 (95% CI 0.83–1.53) in one-sample MR and 1.26 (1.01–1.57) in two-sample MR. In conclusion, low plasma adiponectin is associated with increased risk of type 2 diabetes, an association that could represent a causal relationship.