bluuebunny/crossref_metadata_2025 huggingface dataset:
Right to privacy in modern criminal procedure
Authors: Zuev D. I.
Published: January 2025

The article is devoted to the problem of observance of the individual’s right to privacy in criminal proceedings during the inspection of personal mobile devices, as well as the issue of the impact of digital technologies on the implementation of this constitutional right. The purpose of the study was to substantiate the thesis about the need to expand guarantees for the protection of the right to privacy in criminal proceedings in connection with the digitalization of private life itself. The methods of analysis, synthesis, comparative legal method were used in the study. The article analyzes the concept of «private life» through the prism of regulatory regulation, doctrinal interpretation and law enforcement practice. A comparison of the concept of «private life» and the Anglo-American concept of «privacy» is made, and the experience of the ECHR and the United States on the content of the right to privacy is also considered. As a result of the study, the definition of the right to privacy was formulated and criteria for attributing information to private life were proposed, as well as the need to extend the legal regime of protection to virtual privacy was justified. The results obtained can be used in further research on the specifics of the implementation of the principles of the criminal process, use of computer information in criminal proceedings, as well as in the study of other problems on related topics.
Supervision of the prosecutor over the preliminary investigation bodies: concept, subject and content
Authors: Korchagina K. A.
Published: January 2025

The article discusses the key problem of prosecutorial supervision in Russia – the uncertainty of the subject and content of the prosecutor’s supervisory powers in pre-trial proceedings. The main function of the prosecutor’s office is to monitor compliance with the law, but its boundaries and powers are not clearly defined in the legislation. This creates difficulties in law enforcement and scientific research, which ultimately affects the effectiveness of criminal prosecution and protection of citizens’ rights. Prosecutor’s supervision should not interfere with the activities of investigative bodies, but should monitor the legality of their actions, especially those that affect constitutional rights. The purpose of this study is a legal analysis of the current legislation regulating the activities of the prosecutor in pre-trial proceedings, the results of which will help to determine the subject, content and structure of the prosecutor’s supervision over the activities of the preliminary investigation bodies. To solve the problem, it is proposed to revise the legislative norms, clarifying the subject and content of the prosecutor’s supervisory powers, and exclude from the Code of Criminal Procedure functions that duplicate the tasks of the investigation, preserving the prosecutor’s right to cancel illegal decisions of the investigativebodies. It is proposed to exclude from Article 37 of the Code of Criminal Procedure of the Russian Federation the indication that the prosecutor supervision and the powers corresponding to this function, and at the same time introduce into Section VI Chapter 18.1 of the Code of Criminal Procedure of the Russian Federation «Powers of the prosecutor in criminal proceedings», including the following articles: «Article 139.1 Subject of supervision over the activities of preliminary investigation bodies» and «Article 139.2 Powers of the prosecutor for supervision over the activities of the preliminary investigation bodies».
Domestic factors affecting the stability of state power: theoretical approaches and Russian legislation
Authors: Tushko O. Yu.
Published: January 2025

This article proposes an original systematization of the factors influencing the stability of state power, based on the political and legal teachings of foreign authors and historical experience. The main content of the study is devoted to a detailed analysis of domestic factors related to the organization of state power and factors related to the welfare, security and equality of citizens. The first include the “weak” sides of such forms of government as the republic and the monarchy, as well as problems related to legal regulation. The second is the insufficient material security of the population, the insecurity of citizens and their property, the lack (non-observance) of equality in granting rights, assigning responsibilities and bringing to responsibility, and setting taxes. The author correlates theoretical propositions with historical facts and with the current regulatory framework. During the consideration of each of the listed factors, an analysis of modern Russian legislation is carried out in order to identify provisions that prevent the occurrence of the identified risks, and a reasonable assessment of their relevance and significance is given.
Karyometric Parameters of Dorsal Root Ganglia Neurons During Healing of Purulent Wounds
Authors: Fetisov S. O. , Alexeeva N. T. , Klochkova S. V. , Sokolov D. A. , Kvaratskheliya A. G. , Nikityuk D. B.
Published: January 2025

The aim was to conduct a karyometric assessment of neurons in dorsal root ganglia of experimental animals against the background of a purulent wound process with natural healing and with stimula- tion by hydropulse sanitation and the introduction of platelet-rich blood plasma. Material and methods. In an experiment on 100 white mongrel rats, a purulent wound of the lateral surface of the thigh was modeled by introducing a daily culture of Staphyllococcus aureus with a concentration of 1010 microbial bodies. Two groups were formed: natural healing and healing after therapy of hydro-pulse sanitation of the wound with a finely dispersed flow of NaCl followed by the introduction of platelet-rich autologous blood plasma. The material was taken on the 1st, 7th and 14th days. Excision of the lumbar spinal nodes of segments LIII–LV was performed as corresponding to the zonal innervation of the area of the inflicted wound. At the light-optical level, after staining with cresyl violet according to Nissl, the area of the central cross-section of the nuclei of nerve cells was measured, the number of multinucleolar neurons was counted. Statistical processing was carried out using nonparametric statistical methods Mann–Whitney test; for multiple group comparisons, Kruskal–Wallis ANOVA test was used. Results. The nuclei of neurons of dorsal root ganglia responded to the wound process in the area of their innervation by increasing their area, corresponding to the compensatory load against the background of an increase in the number of cells with signs of reactive changes. Conclusion. Combined therapy with hydropulse sanitation and platelet-rich autologous blood plasma leads to greater expression of compensatory reactions in all subpopulations of neurons, manifested in a statistically significant increase in the area of nuclei with maximum values on the 7th day of the experiment.
On the 70th Anniversary of the Birth of Viktor Mikhailovich Chuchkov
Authors: Editorial Article
Published: January 2025

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Effect of encapsulating agent mixtures on the stability and bioaccessibility of b-carotene encapsulated by freeze drying
Authors: Gordillo-Herrera Adrian , Ventura-Canseco Lucia María Cristina , Luján-Hidalgo María Celina , Mendoza-Avendaño Claudia , Gutiérrez-Miceli Federico , Abud-Archila Miguel
Published: January 2025

b-carotene is the most widely distributed carotenoid in foods and is characterized by its antioxidant and nutritional properties, so its consumption has health benefits. However, it is sensitive to factors such as the presence of oxygen, light and high temperatures. Therefore, the objective of the present study was to study the encapsulation process of b-carotene by freeze drying, using maltodextrin and mixtures with other encapsulating agents, evaluating the encapsulation efficiency, as well as the stability of the encapsulated b-carotene during storage at room temperature (30 °C) and refrigeration (8 °C), the antioxidant activity and bioaccessibility. The results showed that the mixtures of maltodextrin-gum Arabic and maltodextrin-soy protein presented higher encapsulation efficiency (50.40±3.96 y 49.18±5.18%) respectively. While the maltodextrin-soy milk mixture allowed the highest concentration of b-carotene to be maintained at the end of the study, as well as the one with the highest antioxidant activity (AA). Similarly, this mixture presented the highest bioaccessibility of b-carotene in the intestinal phase. Therefore, the use of different encapsulating agents for encapsulation by freeze drying could be used as a protective system and controlled release for sensitive fat-soluble compounds.
Effect of Different Feeding Method on Feed Conversion and Growth of Common Carp (Cyprinus carpio) in Floating Net Cage
Authors: Utomo N.B.P , Hasanah P. , Mokoginta I.
Published: January 2025

This experiment was conducted to evaluate the effectiveness of two feeding methods commonly used in cage culture of carp Cyprinus carpio at Jatiluhur Lake. The results showed that the application of "at satiation feeding method" was more effective than "fixed method" (8% of body weight) indicating with food conversion ratio of 1.79 versus 1.84 and daily growth rate of 3.79% versus 3.42%. Keywords: common carp, Cyprinus carpio, FCR, at satiation, growth, cage culture   ABSTRAK Penelitian ini dilakukan untuk mengevaluasi efektivitas dua metode pemberian pakan yang umum digunakan dalam budidaya keramba jaring apung untuk ikan mas di Waduk Jatiluhur.  Hasil penelitian menunjukkan bahwa pemberian pakan secara satiasi lebih efektif dibandingkan dengan pemberian pakan sebanyak 8% dari bobot biomassa, dengan nilai konversi pakan sebesar 1,79 yang lebih kecil dibandingkan perlakuan pakan sebanyak 8% (1,84) dan pertumbuhan harian sebesar 3,79% (vs. 3,42%). Kata kunci: ikan mas, Cyprinus carpio, FCR, at satiation, pertumbuhan, keramba jaring apung
Management tactics for patients with leukoceratosis of the oral mucosa
Authors: Shishkin Vladislav D. , Makedonova Yulia A. , Kabytova Maria V. , Devyatchenko Lilia A. , Bondarchuk Anastasia I.
Published: January 2025

Leukoplakia is the most common precancerous lesion of the oral mucosa. The prevalence of this disease has been steadily increasing in the last few years. In addition, it is recommended to distinguish between this condition and other possible lesions with a similar clinical picture. Such a rapid increase in morbidity is associated with bad habits that are gaining popularity. We conducted a screening examination of patients by autologous fluorescence examination of the oral mucosa. Based on the results of the examination, a treatment plan was drawn up for patients, taking into account the risks of malignant transformation. All patients were under dynamic supervision. Based on the results of the study, patients with a history of leukoceratosis should regularly visit a dentist.
The principle of morpho-functional symmetry-asymmetry in the formation of contractile activity of the uterus during physiological and complicated pregnancy
Authors: Botasheva Tatyana L. , Kotieva Inga M. , Grigoryan Anahit K. , Kudrin Rodion A. , Klaucek Sergey V. , Klaucek Sergey V. , Kaushanskaya Lyudmila V. , Zheleznyakova Elena V. , Zavodnov Oleg P.
Published: January 2025

The functional pairing of the uterus determines the formation of localized and generalized forms of uterine activity, the study of which makes it possible to identify contractile predictors of preterm birth. Normally, uterine contractions first occur in the II–III trimesters of pregnancy and their aim is to ensure an optimal level of blood flow and transplacental exchange in the uteroplacental complex within the framework of the uteroplacental “pump”. It is of value importance to search those forms of uterine contractions that accompany preterm labor. Since uterine contractions are initiated predominantly in the subplacental area of the myometrium, the modulating role in this process belongs to the area where the placenta is located. Aim: The identification of the characteristics of contractions in the right and left parts of the uterus in physiological and complicated pregnancy, depending on the area of predominant location of the placenta. Materials and methods: 149 women with uncomplicated pregnancy and 126 with premature birth were examined. Features of contractile activity of the uterus were revealed using mechanohysterography for 40 minutes from symmetrical sections of the left and right sections of the anterior abdominal wall at the level of the umbilical ring. Results: It has been established that the physiological course of gestation is characterized by asymmetrical (right- and left-sided) forms of uterine contractions, regardless of the location of the placenta. The right parts of the uterus are normally more functionally active compared to the left. Conclusion: For uncomplicated pregnancy, unilateral contractions are most common, which help to maintain constant intra-amniotic pressure and preserve the lower uterine segment and cervix, because according to the physiological mechanism, they are isotonic. Women with preterm birth have symmetrical bilateral contractile uterine activity, which is isometric, leading to increased intra-amnial pressure, cervical shortening and ripening and preterm birth.
The phenomenon of metorhisis and embryonic organogenesis
Authors: Akhmatov Alexander V. , Spirina Yulia S. , Ledneva Daria S. , Aptekar Igor A. , Markov Alexander A. , Steblyuk Alexander N. , Shidin Vladimir A. , Soloviev Georgy S. , Nurgalieva Aliya R. , Solovyova Olga G.
Published: January 2025

The article focuses on the importance of metorhisis as a mechanism of embryonic organogenesis, for which the dynamics of the morphometric dynamics of the epithelium and the underlying mesenchyme of embryonic organs are traced.
Material and methods: Using the methods of light and electron microscopy, the mechanism and local transformation of the epithelial lining of the stomodeum, Rathke’s pouch (RP) and the pharyngeal gut of the human embryo [a total of 127 embryos at Carnegie stages 12–23 (SC)] were studied in women with their informed consent in health care facilities in Tyumen.
Results: In the head section of the human embryo, the initiation of methorosis is localized in the CR zone; parallel differentiation of the epithelial and mesenchymal components of living organs is observed – the stomodeum, CR, pharyngeal intestine, and pituitary gland.
Prevalence of genital and extragenital pathology of children and adolescents during the COVID-19 pandemic as a factor affecting the reproductive potential of the younger generation
Authors: Antipov Mikhail S. , Polyanskaya Ekaterina S. , Barinova Irina A. , Zharkin Nikolay A.
Published: January 2025

Objective: To study the genital and extragenital morbidity of children and adolescents of a large industrial agglomeration of the Moscow region in dynamics over 3 years of the pandemic of the new coronavirus infection COVID-19, negatively affecting their reproductive health.
Materials and methods: A comparative analysis of the dynamics of the frequency of general morbidity and pathology, directly or indirectly affecting the reproductive health of children of various age groups for 3 years of the pandemic (2019–2021). Relative and dynamic indicators reflecting the frequency and specific weight of individual nosological units in the overall morbidity were calculated.
Results: Against the background of a significant prevalence of respiratory diseases, is noted that there were no statistically significant differences in the frequency and nature of the overall morbidity of children in the population aspect during the pandemic. Dynamics of diseases that directly affect the reproductive health of children did not show significant differences. However, were revealed in the increase in the incidence of general morbidity in younger children, in adolescent girls compared with boys, a statistically significant prevalence of obesity, thyroid diseases in adolescent girls compared with boys and the nervous system in girls.
Conclusion: The obtained results allow to identify the most important areas necessary for carrying out therapeutic and preventive measures that contribute to increasing the level of reproductive health of the younger generation.
Dispersive viscoelastic as an additional support in cataract surgery with incompetent of zonula ciliaris
Authors: Abdugaffarov Sayidabrorbek O. , Grigorieva Yulia V. , Ilinskaya Irina A. , Kopayev Sergey Yu.
Published: January 2025

To perform the review, a search of literature sources was analyzed in the PubMed abstract database using the keywords “cataract”, “lens subluxation”, “OVD” and data from Russian publications on the topic of the article for the period up to 2023 inclusive.
There were 2 patients under observation: a 67 year old patient with a diagnosis of OS: Complicated cataract, grade 2 lens subluxation. Primary open-angle glaucoma 2a, operated on. Pseudoexfoliation syndrome. Visual acuity on admission vis OS = 0.2. The second patient, 68 years old, diagnosed with OS: Complicated cataract, grade 2 lens subluxation. Pseudoexfoliation syndrome. Visual acuity on admission OS = 0.1 n/k. Both patients underwent phacoemulsification with IOL implantation using dispersive viscoelastic as an additional support. Results: On the first day after surgery, the first patient’s uncorrected visual acuity was Vis OS = 0.8. In the second patient, on the first day after surgery, visual acuity was Vis OS = 0.8. Both patients were subjectively satisfied with the visual functions obtained. Conclusion: Thus, this clinical case demonstrates a very successful implementation of cataract phacoemulsification with IOL implantation in patients with lens ligament failure.
Allostasis: genesis and allostatic load
Authors: Sevriukova Galina A.
Published: January 2025

A search for information in open sources of scientific literature was carried out to understand the phenomenon of allostasis and study the influence of allostatic load on the human body. Allostasis is considered in comparison with general adaptation syndrome and chronic stress. The article discusses the possibility of differentiating the allostatic state depending on its genesis: physiologically determined allostasis and clinically determined allostasis. The boundary between physiologically and clinically determined allostasis is determined by the allostatic load. The search for informative biomarkers of the allostatic state and the calculation of the allostatic load index open up promising opportunities for managing the adaptation process and developing preventive measures to optimize the functional state of the body and improve human performance.
The use of ozone in therapeutic dentistry
Authors: Starikova Inna V. , Chaplieva Elena M. , Piterskaya Natalia V. , Kuznetsov Maxim R. , Litvyakova Svetlana V. , Starikova Elena V.
Published: January 2025

A promising area of modern dentistry is the so-called minimally invasive dentistry (minimal intervention dentistry – MID). The main principle of which is the use of non-invasive or minimally invasive technologies. Currently, not only traditional medicinal treatment with antiseptic solutions is used to combat microorganisms, but also innovative technologies. According to most researchers, ozone therapy is a highly effective non – drug treatment method with bactericidal, antiviral, fungicidal, immunomodulatory, antihypoxic and detoxifying effects. It is used in the treatment of caries, in periodontics, endodontics, treatment of diseases of the oral mucosa (SOPR), maxillofacial surgery.
Optimization of respiratory and emotional-behavioral patterns in chronic tracheostomy patients using sensormotor control of breathing with biofeedback
Authors: Faynshteyn Dmitry V. , Fokina Anna S. , Sevriukova Galina A. , Klitochenko Grigory V. , Klauchek Sergey V.
Published: January 2025

An analysis of the effectiveness of using the method of sensorimotor control of breathing with biofeedback by chronic tracheostomy patients was carried out. The bioelectrical activity of the brain was studied using electroencephalography. A course of using sensorimotor breathing control procedures with biofeedback has a positive effect on the level of bioelectrical activity of the brain. Stable preservation of the effect of course use was shown 30 days after application of the method. This technique optimizes respiratory function by the breathing pattern in chronic tracheostomy patients, as allostatic load. The method of sensorimotor breathing control with biofeedback is recommended to be used as a «instrument» for managing the emotional and behavioral state of chronic tracheostomy patients.
Development and validation of a method for screening NLRP3 inflammasome inhibitors on primary macrophages from C57bl/6j mice
Authors: Danilov Roman D. , Sokolova Elena V. , Zakharova Ekaterina K. , Babkov Denis A.
Published: January 2025

Inflammasomes are high-molecular-weight protein complexes that are activated by various cellular patterns and play a key role in the signalling pathways of the innate immune response. The NLRP3 inflammasome is the most studied due to its ability to recognise a wide range of endogenous and exogenous activators, which explains its involvement in the pathogenesis of inflammatory and metabolic diseases, including diabetes, atherosclerosis and neurodegenerative pathologies. Inhibition of NLRP3 activation is a promising avenue for finding novel therapies for inflammation-associated diseases. Peritoneal murine macrophages were isolated and NLRP3 inflammasome activity was investigated. Optimal experimental conditions were determined and the quality of the technique was assessed using the Z-factor.
Possibilities of histological examination in studying the adequacy of corneal saturation with riboflavin solution during partial deepithelization
Authors: Solodkova Elena G. , Izmailova Svetlana B. , Zakharov Igor N. , Fokin Viktor P. , Balalin Sergey V. , Zagrebin Valery L. , Lobanov Evgeny V. , Le Van Hoang
Published: January 2025

A comparative analysis of corneal saturation with riboflavin solution during standard, modified and transepithelial techniques of corneal collagen crosslinking on 15 porcine cadaveric eyes using the histologic method of investigation was carried out. The results of the study confirmed the need for corneal de-epithelialization to ensure sufficient saturation of the cornea with riboflavin solution. Partial de-epithelization in the area of keratoconus is admissible at carrying out ultraviolet crosslinking of corneal collagen (UV-CXL), because, according to the results of the histological method of research, there is a spreading of riboflavin solution into the corneal stroma under the intact epithelium.
Experimental modeling of a bone defect to study the regenerative potential of osteoplastic materials in conditions close to the alveolar bone of human jaws
Authors: Stomatov Dmitry V. , Dolgalev Alexander A. , Stomatov Alexander V. , Makarova Nadezhda I. , Eremina Natalia V. , Boyko Evgenii M.
Published: January 2025

The growing demand for osteoplastic materials leads to the interest of researchers in the development and study of new products, one of the most popular among which are xenografts. Taking into account the disadvantages of known animal models for testing materials in vivo and the intention to investigate the properties of materials in terms of their further application in dental practice, the purpose of this study was to propose a new experimental animal model for studying the regenerative potential of modern osteoplastic materials in conditions close to the alveolar part of human jaws by developing surgical access to a previously unexplored area of the elbow the appendages of a sheep. In three mature sheep, four bone defects were created in the area of the ulnar processes of the ulna bones of the right and left forelimbs. The defects were filled with samples of xenogenic materials, one was left under a blood clot as a control. From above, the defects were covered with a collagen membrane fixed with titanium pins. The animals were removed from the experiment 3 weeks, 3 months and 6 months after surgery. To evaluate the results of the experiment, computer microtomography and histological methods were used. The proposed model satisfies the criterion of a bone defect of critical size by determining a defect of the smallest size that does not heal without treatment for a certain period. The experimental approach developed by us makes it possible to use a fairly simple surgical approach for implanting the material under study into a site with similar architectonics to the alveolar bone of the human jaw, while with low morbidity for the animal. Within the framework of the proposed model, the selected research methods provide an opportunity to assess the course of the regenerative process in a given localization at different stages.
The role of mucin in non-specific ulcerative colitis
Authors: Todorov Sergey S. , Polesovoy Philipp V.
Published: January 2025

The study of mucin in the mucosa in ulcerative colitis represents promising basic research that may help improve therapeutic outcomes. A comparative morphological study of the mucous membrane in chronic superficial colitis and ulcerative colitis was carried out in the work. It was noted that in ulcerative colitis there is a progressive atrophy of the columnar epithelium, crypts and goblet cells, a decrease in mucin secretion and a change in its characteristics with a predominance of alcian + mucopolysaccharides. It is possible that a violation of the secretion of mucus in the mucous membrane of the colon can lead to the development of dysregenerative and dysplastic processes, which requires further study.
Injection correction of the periorbital region, types, complications (literature review)
Authors: Kulova Zhanna B. , Pakhomova Regina A. , Kochetova Tatyana F. , Kalashnikova Natalia G. , Kuzmenko Daria P.
Published: January 2025

The article discusses the features of injection correction of the periorbital region and the complications that arise in this case. According to modern research and statistical data, there has recently been an increase in the use of injectable drugs for face correction. At the same time, an increase in the number of complications was noted. These include both mild complications in the form of bruises, surface deformities, infectious lesions, and complex ones, which include skin, vascular lesions, as well as damage to the visual organs. The latter are rare in practice, but they can lead to a complete loss of visual function. The aim of the study is a systematic review of the literature data on injection correction of the periorbital region, frequent complications and methods of their correction. The methods of scientific research are based on the analysis of literary information, the synthesis of opinions. The basis of the study is the processing of scientific and statistical information concerning the use of injection correction of the periorbital region. The result of the study is to conduct a literary review and collect reliable research data on the features of injectable correction of the periorbital region, complications arising after intervention, and the possibilities of their prevention and correction.
Age evolution of kinematic parameters of body movement
Authors: Smolkova Lidiya V. , Trofimov Anatoly O. , Cherepanov Ivan D. , Dolganova Tamara I. , Dolganov Dmitry V.
Published: January 2025

Purpose – evaluation of the age evolution of the kinematics of the pelvis, trunk and head.
Materials and methods. Research methodology – 3D-video analysis of gait, kinematics analysis in QTM and Visual3D programs with automated calculation of values. The examined groups were formed: I – 13 people aged 3–6 years (4.5 ± 0.83); II – 18 people 8–11 years old (9.9 ± 1.01); III – 15 people aged 12–16 (15.0 ± 0.86). The research results are presented in tables.
Conclusions. Normative values in three planes of the parameters of the kinematics of the pelvis, torso and head in the age aspect are proposed. The age evolution of the dynamic balance correction strategy is formed in the sagittal and horizontal planes mainly due to the kinematics of the pelvis, in the frontal plane – due to the kinematics of the body. Gender correction of the dynamic balance manifests itself in the frontal plane from 3-6 years old, the functional maturity of achieving a horizontal gaze is formed faster in girls than in boys.
Histological and immunohistochemical changes in gonadotropic endocrinocytes of the pituitary gland of female rats exposed to dark deprivation
Authors: Kondakova Larisa I.
Published: January 2025

The effect of prolonged light desynchronosis on the body requires further study to understand its effect on the reproductive system and to study the adaptation of the body against this background, after the abolition of dark deprivation. The aim is to identify histological and immunohistochemical changes in gonadotropic endocrinocytes of the adenohypophysis of female rats under the influence of dark deprivation. The study involved 18 sexually mature white female rats (control group, n = 6) was under artificial lighting 12/12 (light/dark) for 30 days, experimental groups 1 and 2 – under 24-hour artificial lighting 24/0 (light/dark), then the animals of group 2 were placed in 12/12 mode for 14 days. 30-day dark deprivation caused an increase in FSH levels, an increase in the area, volume and perimeter of gonadotropic endocrinocytes by 19.95 % (p 0.001), 73.4 % (p 0.001), 18.2 % (p 0.001), respectively; an increase in the area, volume and perimeter of the core by 26.82 % (p 0.05), 26.82 % (p 0.001), 10.07 % (p 0.05), respectively. Immunohistochemical examination showed an increase in the specific area of caspase-3 of immunoreactive gonadotropic endocrinocytes by 22.4 % (p 0.05), a decrease in the expression of Klotho protein by 21.2 % (p 0.05). 14 days after the cancellation of dark deprivation, the restoration of FSH levels and the size of gonadotropic endocrinocytes was revealed.
Polymorphism of microsomal epoxide hydrolase and glutathione-S-transferase genes as a predictor of the effectiveness of pharmacotherapy
Authors: Gulian Izabella S. , Eliseeva Ekaterina V. , Apanasevich Vladimir I. , Gulian Grant S.
Published: January 2025

Pharmacogenetics is one of the dynamic and rapidly developing areas contributing to the development of personalized medicine. It is based on the determination of polymorphic variants of genes and drug tolerance, the development of side effects, as well as the clinical response to treatment. The study of polymorphisms of genes in the xenobiotic biotransformation system is one of the promising areas in the development of personalized medicine of multifactorial diseases. In this article, we presented literature data on the influence of polymorphisms in genes of the xenobiotic biotransformation system on the effectiveness of pharmacotherapy.
Divulgação científica no âmbito da plataformização
Authors: Lima Beatriz Oliveira de Almeida , Alves Lynn Rosalina Gama
Published: January 2025

Considerando a Cultura Digital um fenômeno ubíquo na contemporaneidade, a Divulgação Científica (DC) também vem sendo performada pelos processos inerentes da Plataformização, Dataficação e Performatividade Algorítmica. Desse modo, o artigo objetiva mapear a rede de canais de DC do YouTube a partir do Science Vlogs Brasil (SVBR), refletindo sobre as possíveis afetações para o campo da educação científica. Assim, utilizamos os Métodos Digitais para acesso aos dados via APIs do YouTube. Os resultados possibilitam a visualização das relações de uma rede densa, na qual os mais indicados são das Ciências Exatas e Naturais. A análise também aponta indicadores da performatividade algorítmica da plataforma sinalizando a importância de intervenções de DC com olhar crítico frente aos ambientes plataformizados.
THE RELATIONSHIP OF PSYCHOLOGICAL AND PHYSICAL IMPACTS ON DRUG ABUSE TO ORAL AND DENTAL HYGIENE
Authors: Pertiwi Indraswari Wahyu , Hamdani Riky , Sari Galuh Dwinta , Hatta Isnur , Taufiqurrahman Irham
Published: January 2025

Background: Drug usage can have a negative psychological and physical influence on dental hygiene. Drug abusers' low priority for oral and dental health is linked to behavioral changes, needle phobia, and dread of the dentist, all of which are part of the psychological impact of drug usage. Poor dental and oral hygiene in drug users can be attributed to reduced motor function, which is part of the physical side effects of drug use. Objective: To analyze the psychological and physical impact of drug abuse on oral hygiene at IPWL Griya Pemberdayaan Banjarbaru city. Methods: Using an analytic observational study using a cross-sectional method and a basic random sample strategy. The population of drug users in the IPWL Griya Pemberdayaan Banjarbaru city was 50 persons, and a sample of 38 people was acquired. The WHOQOL-Bref questionnaire was utilized in this study to assess the psychological and physical effects of drug misuse, as well as the OHI-S index criteria to assess dental and oral hygiene status, which were then analyzed using the Spearman test. Results: The Spearman test showed that there is a relationship between the psychological impact of drug abuse on oral hygiene with a strong weak correlation, and there is a relationship between the physical impact of drug abuse on oral hygiene with a fairly strong correlation. Conclusion: it is necessary to improve dental and oral hygiene to reduce the psychological and physical impact of drug abuse.
CORRELATION BETWEEN MALOCCLUSION AND HISTORY OF BULLYING IN ADOLESCENTS AT MTSN 2 TANAH LAUT SOUTH KALIMANTAN
Authors: Arif Widyandini Aulia , Budipramana Melisa , Sari Galuh Dwinta , Ichrom Nahzi Muhammad Yanuar , Hatta Isnur
Published: January 2025

Background: Bullying in schools has been a source of concern for societies all over the world. The physical aspect is one of the triggers for bullying in adolescents. Assessment of these physical aspects; such as, weight, height, and facial appearance include the condition of the teeth. Moreover, prominent conditions of malocclusion; such as, gaps between teeth, crowding, overbite and overjet, are the most frequently reported targets by bullies. Purpose: To analyze the relationship between malocclusion and history of bullying in adolescents at MTsN 2 Tanah Laut South Kalimantan. Methods: Cross sectional research design is the methodology used in this observational analytical study. ICON was used to assess malocclusion severity and a validated questionnaire adapted from previous research was used to assess bullying history. In addition, the samples obtained were 86 respondents aged 12-14 years. Results: The highest frequency distribution in this study is malocclusion in the easy category based on ICON by 41 people (47.7%) and history of bullying in the category of bullying has not happened to the respondent in the last two months as many as 69 people (57.4%). A significant correlation was found in the results of the Spearman analysis test between malocclusion based on ICON and a history of bullying. Conclusion: Malocclusion and history of bullying in adolescents at MTsN 2 Tanah Laut South Kalimantan are correlated in a one-way manner, meaning that the severity of the malocclusion category increases in tandem with the history of bullying category.
Validitas Perangkat Pembelajaran Predict Observe Explain (POE) Berbasis Multirepresentasi untuk Mendukung Pemahaman Konsep Optika
Authors: Dinata Pri Ariadi Cahya , Hartanto Theo Jhoni , Hakim Luqman
Published: January 2025

Penelitian ini bertujuan untuk mengembangkan perangkat pembelajaran Predict-Observe-Explain (POE) berbasis multirepresentasi yang valid untuk mendukung pemahaman konsep optika geometri. Penelitian ini menggunakan model pengembangan ADDIE, dengan fokus pada tiga tahap awal: analisis, desain, dan pengembangan. Validasi dilakukan oleh lima validator menggunakan instrumen berbasis skala Likert yang mencakup aspek konstruksi, konten, dan bahasa. Hasil validasi menunjukkan bahwa perangkat pembelajaran, termasuk skenario pembelajaran dan lembar kerja mahasiswa, berada dalam kategori "sangat baik" pada semua aspek. Model POE berorientasi multirepresentasi terbukti mampu memfasilitasi dekonstruksi miskonsepsi dan meningkatkan pemahaman konsep optika geometri mahasiswa. Temuan ini memberikan kontribusi penting bagi pengembangan metode pembelajaran fisika yang lebih efektif, khususnya pada tingkat pendidikan tinggi.
The Analysis of Land Suitability for Sustainable Settlement Development in Kabupaten Manokwari, Provinsi Papua Barat
Authors: Ibal La , Madaul Rahful Ahmad , Sraun Randy Stenly
Published: January 2025

The imbalance between population growth and residential land use by the Spatial Plan and land characteristics has given rise to various problems in Kabupaten Manokwari, including changes in land use and environmental degradation. This study analyzes land suitability as a basis for sustainable settlement development in Kabupaten Manokwari. The research method uses weighting analysis, LCU (Land Capability Unit) overlay, and settlement carrying capacity analysis. The results of the study indicate that (a) Based on the land capability analysis, land development in Kabupaten Manokwari that can be used as a settlement development area is class d and e because it has a flat topography contour and can be developed with a maximum land cover of 70% of the area with an area of 103,053.42 Ha and 44,736.64 Ha respectively; (b) The land carrying capacity of the settlement development area in Kabupaten Manokwari is 3,662.02 Ha; and (c) Sustainable settlement development in Kabupaten Manokwari based on physical components that the direction of raw water utilization in Kabupaten Manokwari is very good with an area of 147,790.06 ha, this shows that for Kabupaten Manokwari there are no obstacles in the utilization of raw water because it has water sources that can be utilized as raw water sources. These findings provide strategic recommendations for the development of residential areas by considering environmental and socio-economic sustainability aspects and supporting the achievement of SDGs goals, especially related to the availability of clean water and sanitation.
Analysis of the Needs for Developing a Pocketbook on Eruption Disaster Mitigation Based on Local Vocabulary of the Mount Merapi Slope Community in Kabupaten Klaten
Authors: Anggraheny Kunthum Ria , Sholihah Umi
Published: January 2025

Communication is one component of disaster mitigation, conveying information related to disasters is necessary in reducing disaster risk. The use of foreign vocabulary for disaster terms is difficult to understand for the elderly on the slopes of Mount Merapi, so this research aims to determine the need for a disaster mitigation pocketbook based on local vocabulary in reducing disaster risks and identifying local vocabulary for the Merapi Eruption disaster in mountain slope communities. Developing of a disaster mitigation pocketbook using the ADDIE model is Analysis, Design, Development, Implementation, and Evaluation, research is only in the first stage of the 5 stages, limited to the analysis stage. Respondents in this study were elderly people and elderly companions, in three villages on the slopes of Mount Merapi, namely Sidorejo, Tegalmulyo, and Balerante villages, which are villages directly affected by the eruption of Mount Merapi. The results of the needs analysis showed that 88% of elderly companions agreed with the existence of a disaster mitigation pocketbook based on local vocabulary, while for the elderly 86% agreed. The incorrect local vocabulary identification is the term "lava flood" in the local vocabulary "bena lenduth". Developinh a disaster mitigation pocketbook based on local vocabulary is expected to provide informative communication between elderly companions and the elderly in increasing disaster preparedness.
Planning for the Development of Pantai Utara of Kabupaten Manokwari (Study on Nuni Beach) as a Tourism Area
Authors: Murni Murni , Abubakar Endang , Rumbarar Samuel
Published: January 2025

The sustainability of the tourism area can be realized if there is a balance between aspects in the development area, so that the area is able to show the functionality between each aspect in the development area. The analysis methods in this study are qualitative analysis, site analysis, and SWOT analysis. The results of this study are (a) The development of the Nuni Beach tourism area is planned with a clear division of zones, namely the Public Zone, Semi-Private Zone, and Private Zone, to facilitate accessibility and comfort for visitors and managers. The total area of the planned area reaches ± 71,249.3 m², including various facilities such as parking areas, management offices, accommodation, multi-purpose rooms, as well as places to eat and parks. This approach is expected to support the growth of planned and sustainable tourism in Nuni Beach, while maintaining environmental sustainability and providing a pleasant experience for tourists; and (b) The development strategy of Nuni Beach as a tourism area focuses on utilizing existing strengths and opportunities through an aggressive approach, while overcoming weaknesses and threats with comprehensive planning. Through effective promotion, infrastructure improvement, human resource training, and sustainable environmental management, it is hoped that Nuni Beach can develop into an attractive and sustainable tourist destination, attracting more tourists while preserving nature.
Mapping of Forest and Land Fire Vulnerability Levels in Kabupaten Tanah Laut, Provinsi Kalimantan Selatan
Authors: Marbun Yessyca Dian Patriani , Kumalawati Rosalina , Iskandar Akhmad , Efendi Muhammad
Published: January 2025

The purpose of this study is to determine the level of vulnerability to forest and land fires in Tanah Laut Regency and to provide input recommendations for preventing forest and land fires related to the high areas prone to forest and land fires in Tanah Laut Regency. This study uses a mix method or quantitative and qualitative methods. The quantitative method is a spatial approach used for mapping the vulnerability to forest and land fires, while qualitative methods with descriptive analysis are used to provide input recommendations for preventing forest and land fires in Tanah Laut Regency. The results of this study are that the highest level of vulnerability to forest and land fires is at the High level with an area of 217,211.08 hectares or 56.51% of the total area of Tanah Laut Regency. Input recommendations for preventing forest and land fires are carried out by involving various steps, one of which is conducting a depth interview with the Manggala Agni service and the sub-district head in Tanah Laut Regency regarding the Patrol SOP carried out to prevent forest and land fires.
IDENTIFIKASI SEBARAN JENIS TUMBUHAN KAYU TINGKAT TIANG DAN POHON DI BUKIT PANDAMARAN KHDTK MANDIANGIN ULM
Authors: Saputri Mutia Riska , Payung Damaris , Nugroho Yusanto
Published: January 2025

Recognizing the composition of forest ecosystems is important to maximize forest utilization and conservation. One of the steps that can be used is to identify the vegetation in the forest. Pandamaran Hill, which is located at an altitude of 275 meters above sea level, has a forest with conditions that are still rarely touched by humans so that identification of vegetation at that location is important. This study aims to analyze the distribution and identify plant species at the pole and tree growth levels located in Bukit Pandamaran KHDTK Mandiangin. The method used to determine sample points is based on purposive sampling method with line intercept method. The size of the sample plot in this study is based on the species area curve to determine the minimum sample plot to be made. The results of this study showed that the distribution of pole-level plants in the three locations was the type of Tampar Badak, Rukam, and Margatahan while the distribution of tree-level plants in the three locations was the type of Tengkook Ayam, Serai Putih, and Marsihung. The pole level in locations I, II and III for the highest INP value is the same type of Damar Kumbang. Similar to the pole level, the tree level at locations I, II and III the highest INP value was obtained by the Damar Kumbang species. Mengenali susunan komposisi ekosistem hutan penting untuk memaksimalkan pemanfaatan dan pelestarian hutan. Salah satu langkah yang dapat digunakan yaitu melakukan identifikasi terhadap vegetasi yang terdapat dalam hutan. Bukit Pandamaran yang berada di ketinggian 275 mdpl memiliki hutan dengan kondisi yang masih jarang dijamah manusia sehingga identifikasi vegetasi pada lokasi tersebut penting dilakukan. Penelitian ini bertujuan untuk menganalisis sebaran dan mengidentifikasi jenis tumbuhan pada tingkat pertumbuhan tiang dan pohon yang terletak Bukit Pandamaran KHDTK Mandiangin. Metode yang digunakan untuk menentukan titik sampel berdasarkan metode purposive sampling dengan plot garis berpetak (line intercept method). Ukuran petak contoh dalam penelitian ini berdasarkan curva species area untuk menetukan petak contoh minimal yang akan dibuat. Hasil penelitian ini menunjukkan Sebaran tumbuhan tingkat tiang pada ketiga lokasi yakni jenis Tampar Badak, Rukam, dan Margatahan sedangkan sebaran tumbuhan tingkat pohon pada ketiga lokasi yakni jenis Tengkook Ayam, Serai Putih, dan Marsihung. Tingkat tiang di lokasi I, II dan III untuk nilai INP tertinggi nya yakni jenis yang sama yaitu Damar Kumbang. Sama halnya dengan tingkat tiang, tingkat pohon pada lokasi I, II dan III nilai INP tertinggi diperoleh jenis Damar Kumbang.
Analisis Proksimat Madu Kelulut (Heterotrigona itama) dari Kelurahan Palam Banjarbaru Kalimantan Selatan
Authors: Fikri Hendriannur , Satriadi Trisnu , Mahdie Muhammad Faisal
Published: January 2025

ABSTRACT. Kelulut bees that produce honey are one of the non-timber forest products that are rich in benefits. The content contained in kelulut bee honey has a positive impact on health if used properly. The purpose of this study was to analyze the proximate content of kelulut honey including protein, water, fat, ash, carbohydrate and calorie content. The honey samples used came from the Palam Banjarbaru Urban Village honey farm and proximate testing was carried out at the Lambung Mangkurat University Faculty of Medicine laboratory Biokomia. The research method used a quantitative approach and data analysis using a descriptive-quantitative approach. The results of the proximate analysis of kelulut honey can be seen that the content in kelulut honey samples is 28.92% water content, 0.18% ash content, 0.45% protein content, 0.03% fat content, 70.36% carbohydrate content and 285.26 for calorie test.ABSTRAK. Lebah kelulut yang menghasilkan madu merupakan salah satu hasil hutan bukan kayu yang kaya akan manfaat. Kandungan dalam madu lebah kelulut memberikan dampak positif bagi kesehatan jika dipergunakan dengan tepat. Tujuan penelitian ini untuk menganalisis kandungan proksimat madu kelulut meliputi uji kadar protein, air, lemak, abu, karbohidrat dan kalori. Sampel madu yang digunakan berasal dari peternakan madu Kelurahan Palam Banjarbaru serta pengujian proksimat dilakukan di Labolatorium Biokimia Fakultas Kedokteran Universitas Lambung Mangkurat. Metode penelitian menggunakan pendekatan kuantitatif dan analisis data menggunakan pendekatan deskriftif–kuantitatif. Hasil analisis proksimat madu kelulut dapat diketahui bahwa kandungan yang ada pada sampel madu kelulut yaitu 28.92 % Kadar Air ,0,18 % kadar abu, 0,45 % kadar protein, 0,03% kadar lemak, 70,36 % kadar karbohidrat dan 285,26 untuk uji kalori.