bluuebunny/crossref_metadata_2025 huggingface dataset:
The Shifting Pendulum: Foreign Investors’ Liability Under Canada’s Common Law for Breaches of Customary International Law
Authors: Haynes Jason
Published: September 2021

In February 2020, the Supreme Court of Canada rendered a decision—Nevsun Resources Ltd. v. Araya, 2020 SCC 5—that can properly be described as revolutionary. In Nevsun, the court found that a Canadian corporation operating in a host state, Eretria, could be liable under Canadian domestic law for human rights abuses committed in Eritrea under customary international law, as incorporated into Canadian domestic law. The decision merits special attention because it is likely to fundamentally change the relationship between foreign investors, host states and the residents of host states adversely affected by investors’ unlawful conduct which amount to modern slavery.
Rigidity properties for commuting automorphisms on tori and solenoids
Authors: EINSIEDLER MANFRED , LINDENSTRAUSS ELON
Published: September 2021

Assuming positive entropy, we prove a measure rigidity theorem for higher rank actions on tori and solenoids by commuting automorphisms. We also apply this result to obtain a complete classification of disjointness and measurable factors for these actions.
Factors connected with anxiety and other neuropsychiatric symptoms in advanced gastric cancer
Authors: Bryniarski Pawel , Bryniarska Magdalena , Jezioro Maciej , Andrysiak Daniel , Filipczak-Bryniarska Iwona
Published: September 2021

Objective:

The aim of study was to determine factors connected with neuropsychiatric symptoms and anxiety in patients with terminal stomach cancer.

Methods:

We analysed retrospectively 134 terminal stomach cancer patients admitted to Palliative Care Unit.

Results:

Patients with anxiety had a greater chance for emergency admission, higher Numerical Rating Scale result, occurrence of cachexia and neuropsychiatric symptoms, longer duration of treatment, higher albumin concentration and lower glucose concentration.

Patients with neuropsychiatric symptoms had greater chance for emergency admission, higher Performance Status scale note, occurrence of dyselectrolytemia, lower albumin concentration. Patients with those symptoms had more than 7 times greater chance for death.

Conclusion:

It is important to know factors connected with neuropsychiatric symptoms and anxiety because thanks to that we could avoid those dangerous clinical symptoms.
GENERALIZED GREEN FUNCTIONS AND UNIPOTENT CLASSES FOR FINITE REDUCTIVE GROUPS, III
Authors: SHOJI TOSHIAKI
Published: September 2021

Lusztig’s algorithm of computing generalized Green functions of reductive groups involves an ambiguity on certain scalars. In this paper, for reductive groups of classical type with arbitrary characteristic, we determine those scalars explicitly, and eliminate the ambiguity. Our results imply that all the generalized Green functions of classical type are computable.
CARACALLA AND ‘ALEXANDER'S PHALANX’: CAUGHT AT A CROSSROADS OF EVIDENCE
Authors: Imrie Alex
Published: September 2021

It is well known that Alexander the Great offered inspiration to successive monarchs and autocrats. Few of these, however, could claim to match the affection shown by the Roman emperor Caracalla (198–217 ce). Caracalla is said to have been an almost pathological aficionado of Alexander, constantly promoting a public association between himself and his idol. One aspect of Caracalla's imitatio Alexandri was allegedly the levy of a peculiar phalangite formation based on the arms and equipment of Alexander's time. For years it was impossible to gauge whether this was a real development or a hostile literary fabrication, but the discovery of funerary remains at Apamea in Syria, which appear to memorialize phalangites and lanciarii, confirmed to some the historicity of Caracalla's bizarre levy. This article argues, however, that the apparently convincing combination of evidence is illusory, and that Caracalla's ‘phalanx’ was rather a convenient label applied to an inherently Roman formation.
WINE TABOO REGARDING WOMEN IN ARCHAIC ROME, ORIGINS OF ITALIAN VITICULTURE, AND THE TASTE OF ANCIENT WINES
Authors: Komar Paulina
Published: September 2021

A number of ancient sources suggests that Roman women in the archaic period were not allowed to drink wine. Various theories have so far been proposed to explain this taboo, most of them assuming that it meant a complete alcohol ban, and relating it to the special role of women in the Roman family. However, a reconsideration of these theories, which takes into account the results of recent studies on the origins of wine consumption in Italy, shows that the archaic wine taboo had more to do with the nature of wine than with the nature of women.
‘STRANGE’ RHETORIC AND HOMERIC RECEPTION IN AELIUS ARISTIDES’EMBASSY SPEECH TO ACHILLES(OR. 52)
Authors: Sansom Stephen A.
Published: September 2021

This article argues that Aelius Aristides adapts the wordatopos(‘strange’, ‘out of place’) as figured speech in hisEmbassy Speech to Achilles, meaning something that is either illogical according to rhetoricaltopoior inconsistent with the text of Homer'sIliad. By doing so, he not only expands the semantic range ofatoposbut also comments on the rhetorical, intertextual, and pedagogical relationship between oratory and the Homeric tradition.
The aetiology of ossicular chain defects in congenital cholesteatoma
Authors: Li X Y , Liu Y , Zhao D H , Liu Y , Sun J J
Published: September 2021

Objective

The aim of the present study was to perform a retrospective review of the lesion sites in congenital middle-ear cholesteatoma and any accompanying ossicular defects, as well as to explore the possible aetiology of congenital middle-ear cholesteatoma associated with such ossicular chain defects.

Method

The clinical characteristics and pathogenic mechanisms of ossicular chain defects were investigated in 10 patients with early-stage congenital middle-ear cholesteatoma confirmed by surgery, from August 2011 to February 2019.

Results

Monofocal cholesteatoma was located in the anterosuperior quadrant in 3 cases and in the posterosuperior quadrant in 7 cases; all 10 cases showed an absence of the long crus of incus, and 8 cases showed a complete or partial absence of stapes superstructure. The lesions were confined to the vestibular window and the stapes region and had no contact with the long crus of the incus or stapes in nine cases. None of the 10 patients had any recurrence of cholesteatoma.

Conclusion

Although cholesteatoma can cause erosion of ossicles, the present cases suggest that residual epithelium of the cholesteatoma may coexist with ossicular malformations. Therefore, the aetiology of the clinical characteristics in these patients may derive from residual epithelial hinderance of ossicle development.
The development of narrative skills in monolingual Swedish-speaking children aged 4 to 9: a longitudinal study
Authors: LINDGREN Josefin
Published: September 2021

This longitudinal study investigated the development of oral narrative skills in monolingual Swedish-speaking children (N = 17). The MAIN Cat/Dog stories were administered at four timepoints between age 4 and 9. Different narrative aspects were found to develop differently. In story comprehension, the children performed high already at T1 (4;4) and were at ceiling at T2 (5;10), whereas story structure developed significantly until T4 (9;4). Narrative length and syntactic complexity reached a plateau at T3 (7;4). Referent introduction was not mastered until T4. The results suggest that general conclusions regarding the development of narrative skills depend on the specific aspects studied.
Impact of the harsh Antarctic environment on mucosal immunity
Authors: Bhushan Brij , Tanwar Himanshi , Eslavath Malleswara Rao , Singh Shashi Bala , Kumar Bhuvnesh , Ganju Lilly
Published: September 2021

Mucosal immunity of Indian Antarctic personnel was analysed during the 34th Indian Scientific Expedition to Antarctica (ISEA) by ship voyage. Serum and salivary IgA, IgA1 and IgA2 levels along with salivary cortisol and TGF-β were quantified by enzyme-linked immunosorbent assay. Samples were collected at three different time points (T1, T2 and T3) during the expedition. Serum and salivary IgA, IgA1 and IgA2 concentrations incrementally increased towards the end of the expedition as compared to the beginning of the expedition. Salivary IgA and TGF-β levels were significantly altered during the expedition. Levels of IgA1 (P = 0.0007) and IgA2 (P = 0.0135) increased significantly at T3 as compared to T1. Additionally, significant changes in serum IgA were observed, with peak levels at T3 (P = 0.0015) and T2 (P < 0.001). However, the level of serum IgA2 was also significantly altered at T3 (P < 0.05) and T2 (P = 0.0006) in comparison with T1. The exact cause of the changes in serum and salivary IgA, IgA1, IgA2 and TGF-β levels during the summer expedition are unknown; however, the changes are evident in mucosal immunity.
Impact of Z score system on the management of coronary artery lesions in Kawasaki disease
Authors: Lorenzoni Raymond P. , Elkins Noah , Quezada Morgan , Silver Ellen J. , Mahgerefteh Joseph , Hsu Daphne T. , Choueiter Nadine F.
Published: September 2021

Background:

Coronary artery aneurysms are well-described in Kawasaki disease and the Multisystem Inflammatory Syndrome in Children and are graded using Z scores. Three Z score systems (Boston, Montreal, and DC) are widely used in North America. The recent Pediatric Heart Network Z score system is derived from the largest diverse sample to-date. The impact of Z score system on the rate of coronary dilation and management was assessed in a large real-world dataset.

Methods:

Using a combined dataset of patients with acute Kawasaki disease from the Children’s Hospital at Montefiore and the National Heart, Lung, and Blood Institute Kawasaki Disease Study, coronary Z scores and the rate of coronary lesions (Z ≥ 2.0) and aneurysms (Z ≥ 2.5) were determined using four Z score systems. Agreement among Z scores and the effect on Kawasaki management were assessed.

Results:

Of 333 patients analysed, 136 were from Montefiore and 197 from the Kawasaki Disease Study. Age, sex, body surface area, and rate of coronary lesions did not differ between the samples. Among the four Z score systems, the rate of acute coronary lesions varied from 24 to 55%. The mean left anterior descending Z scores from Pediatric Heart Network and Boston had a large uniform discrepancy of 1.3. Differences in Z scores among the four systems may change anticoagulation management in up to 22% of a Kawasaki population.

Conclusions:

Choice of Z score system alone may impact Kawasaki disease diagnosis and management. Further research is necessary to determine the ideal coronary Z score system.
Prominent prolapsing Chiari network: presentation and prognosis in paediatric patients
Authors: Joyce James J. , Joyce Thomas R. , Ferns Sunita J.
Published: September 2021

Chiari network is an infrequently visualized web-like structure in the right atrium that is usually thin and small. Rarely, it can be prominent and elongated with protrusion into the right ventricle during diastole and complications have been reported. Thirty-eight patients (median age 2.5 years) with prolapsing Chiari network were identified and associated cardiac abnormalities documented. Echocardiographic right and left heart parameters were measured and compared to normative data. At presentation, the extent of Chiari network prolapse below the tricuspid annulus was 9.1 ± 3.5 mm (mean ± standard deviation), mean pulmonary valve annulus diameter z-value was reduced (-0.91 ± 0.64), and mean aortic valve z-value was enlarged (+0.97 ± 0.87). Fourteen patients exhibited no other cardiac abnormality. Eight were noted to have atrial septal defects, eight demonstrated supraventricular dysrhythmias, six had mild to moderate tricuspid valve regurgitation, and one patient each had an atrial septal aneurysm, severe pulmonic valve stenosis, small perimembranous ventricular septal defect, bicuspid aortic valve, and mild right upper pulmonary vein stenosis. Fourteen patients (37%) were seen in follow-up from 1 to 8.5 years later (median 3.2 years). During that time, the magnitude of prolapse across the tricuspid valve decreased by up to 7 mm (median 2 mm). Interventions were required in three patients, but many associated cardiac abnormalities resolved spontaneously with growth. Thus, the presence of a prolapsing Chiari network has a substantial risk of associated CHDs. However, the extent of Chiari network prolapse gradually decreases and many related abnormalities resolve during growth.
Patent ductus arteriosus stenting: ductal dissection and spasm in pulmonary atresia with intact ventricular septum
Authors: Chen Tsung-Yen , Chen Po-Wei , Wang Jieh-Neng
Published: September 2021

Ductal dissection is rarely mentioned but intractable complication of ductal stenting. We demonstrate the dissection image under fluoroscopy and the use of a relatively large stent as an applicable treatment.
Degree of processing and nutritional value of children’s food products
Authors: Araújo Célia Regina Barbosa de , Ribeiro Karla Danielly da S , Oliveira Amanda Freitas de , Morais Inês Lança de , Breda João , Padrão Patrícia , Moreira Pedro
Published: September 2021

Objective:

This study aimed to characterise the availability, the nutritional composition and the processing degree of industrial foods for 0–36-month-old children according to the neighbourhoods affluence.

Design:

A cross-sectional exploratory study.

Setting:

All food products available in retail stores for children aged 0–36 months were analysed. Data collection took place in two neighbourhoods, comparing two different sociodemographic districts (highv.low per capita income), Campanhã and Foz do Douro in Porto, Portugal.

Participants:

A total of 431 commercially processed food products for children aged 0–36 months which are sold in 23 retail stores were identified. Food products were classified according to their processing degree using the NOVA Food Classification System.

Results:

For NOVA analysis, of the 244 food products that were included 82 (33·6 %) were minimally processed, 25 (10·2 %) processed and 137 (56·1 %) ultra processed. No food product was classified as a culinary ingredient. The products included mostly cereals, yogurts, prevailed in high-income neighbourhoods for the 0–6-month-old group. It was observed that some categories of ultra-processed food (UPF) presented higher amounts of energy, sugars, saturated fat and salt than unprocessed/minimally processed products.

Conclusions:

The high availability of UPF offered for 0–36-month-old children should be considered when designing interventions to promote a healthy diet in infancy.
“The Hall Does Not Make the Space”: Disrupting Concert Hall Norms in Hannibal's One Land, One River, One People
Authors: Safran Benjamin
Published: September 2021

Hannibal's cheering and shouting along with his request for audience participation during the 2015 premiere of his composition One Land, One River, One People caused a stir and created discomfort among the Philadelphia Orchestra audience. I interpret his work as an example of a successful musical direct action within contemporary orchestral music. By exposing and subverting the traditions of the classical concert experience, One Land, One River, One People highlights social boundaries within the genre of classical music itself. I apply Robin James's (2015) concept of Multiracial White Supremacy, or MRWaSP, to contemporary orchestral classical music of the United States. Under late capitalism, MRWaSP helps to explain the potential appeal to an orchestra of commissioning Hannibal, who is known as a “genre-crossing” composer rooted in classical and jazz. Yet I argue that the way in which Hannibal performs his identity along with the piece's inclusion of audience participation allow the music to resist functioning as expected under MRWaSP. Rather than promoting a sense that—as one might expect from the title—we are all “one people,” I see the piece as revealing racial difference and as speaking truth to power.
Recognizing Geology’s Colonial History for Better Policy Today
Authors: Nyblade Maddy , McDonald Jenn
Published: September 2021

The Minnesota Geological Survey has contributed to the dispossession of homelands from Indigenous Peoples. The agency is creating more just policies.
Understanding Aurora Formation with ESA’s Cluster Mission
Authors: Rehnberg Morgan
Published: September 2021

Over 2 decades, Cluster has shed light on the auroral acceleration region, where parallel electric fields send charged particles on a collision course with the atmosphere.
Genetic polymorphism of CYP2C19 and subcortical variability in the human adult brain
Authors: Stingl Julia C. , Scholl Catharina , Bosch Julia E. , Viviani Roberto
Published: September 2021

Pharmacogenetic studies have shown involvement of cytochrome P450 enzymes in the metabolism of psychotropic drugs. However, expression and activity on endogenous substrates in the brain may underlie a constitutive role of these enzymes beyond drug metabolism. CYP2C19, which is expressed in the human fetal brain during neurodevelopment, shows affinity for endogenous compounds including monoaminergic neurotransmitters, steroid hormones, and endocannabinoids. In this study (N = 608), we looked at the genetic polymorphism of CYP2C19 and its potential associations with structural phenotypes of subcortical brain volume with structural imaging. Using two independent volume estimation techniques, we found converging evidence for a positive association betweenCYP2C19activity scores, as inferred from the genotype, and basal ganglia and hippocampal volume. This association was present only in female individuals, raising the possibility that effects on brain morphology may arise through a mechanism involving the metabolism of estrogen steroids.
A five-year retrospective study on the epidemiology of hand, foot and mouth disease in Sabah, Malaysia
Authors: Fong Siat Yee , Mori Daisuke , Rundi Christina , Yap Jun Fai , Jikal Muhammad , Latip A. L. Liza Binti Abd , Johnny Victor , Ahmed Kamruddin
Published: September 2021

Hand, foot, and mouth disease (HFMD) is endemic in Malaysia, with the number of cases increasing. Sabah has experienced several HFMD outbreaks, but information on the epidemiology and molecular characteristics of responsible viruses is scarce. In this study, data of 17,574 reports of HFMD cases in Sabah from 2015 to 2019 were extracted from a public health disease surveillance system and analyzed. Twenty-one swab samples from 13 children were collected from Beaufort, Sabah, during an outbreak in August 2018 for detection and serotyping of causative viruses by semi-nested reverse transcription-polymerase chain reaction (snRT-PCR) of the VP4–VP2 region and consensus degenerate hybrid oligonucleotide primer PCR of the VP1 region, respectively. Nucleotide sequencing and phylogenetic analysis were conducted by the neighbor-joining method. The average annual incidence of HFMD was 94.3 per 100,000 people, with the greatest yearly increase between 2017 and 2018. Swabs from six children were tested positive for enterovirus, of which five were positive for CVA16 and one for EV71. All CVA16 strains belonged to sub-genotype B1a, and the EV71 strain belonged to sub-genotype B5. Phylogenetic analyses indicate that enterovirus genotype shift might be responsible for the increasing trend of HFMD in Sabah, however, further study is needed.
Monocyte-derived and M1 macrophages from ankylosing spondylitis patients released higher TNF-α and expressed more IL1B in response to BzATP than macrophages from healthy subjects
Authors: Akhtari Maryam , Zargar Seyed Jalal , Vojdanian Mahdi , Jamshidi Ahmadreza , Mahmoudi Mahdi
Published: September 2021

Macrophages participate in the pathogenesis of ankylosing spondylitis (AS) by producing inflammatory cytokines. Extracellular adenosine triphosphate (eATP), released during cell stress, acts through purinergic receptors (P2XR and P2YR) and induces inflammatory responses. We investigated the effect of 2ʹ(3ʹ)-O-(4-benzoyl benzoyl) ATP (BzATP) (a prototypic agonist of P2X7R) on the production of inflammatory cytokines in both monocyte-generated (M2-like) and M1 macrophages from patients and controls. Macrophages were differentiated from isolated periphery-monocytes (n = 14 in each group) by macrophage colony-stimulating factor (M-CSF). Using LPS and IFN-γ, macrophages were skewed toward M1 type and were treated with BzATP. Gene expression and protein release of IL-1β, IL-23, and TNF-α were evaluated by real-time PCR and ELISA methods respectively before and after treatment. BzATP significantly increased the protein release of TNF-α and the expression of TNFA and IL1B in monocyte-generated macrophages. Besides, BzATP treatment significantly upregulated IL1B expression, reduced TNFA and IL23A expression, and TNF-α release in M1 macrophages from both groups. Monocyte-generated and M1 macrophages from AS patients released higher TNF-α and expressed more IL1B in response to the same concentration of BzATP treatment respectively. Based on our results, AS macrophages were more sensitive to BzATP treatment and responded more intensively. Besides, the diverse effects of BzATP on monocyte-derived and M1 macrophages in our study may represent the differed inflammatory properties of these two groups of macrophages in response to eATP in the body.
Optimal responsiveness and information flow in networks of heterogeneous neurons
Authors: Di Volo Matteo , Destexhe Alain
Published: September 2021

Cerebral cortex is characterized by a strong neuron-to-neuron heterogeneity, but it is unclear what consequences this may have for cortical computations, while most computational models consider networks of identical units. Here, we study network models of spiking neurons endowed with heterogeneity, that we treat independently for excitatory and inhibitory neurons. We find that heterogeneous networks are generally more responsive, with an optimal responsiveness occurring for levels of heterogeneity found experimentally in different published datasets, for both excitatory and inhibitory neurons. To investigate the underlying mechanisms, we introduce a mean-field model of heterogeneous networks. This mean-field model captures optimal responsiveness and suggests that it is related to the stability of the spontaneous asynchronous state. The mean-field model also predicts that new dynamical states can emerge from heterogeneity, a prediction which is confirmed by network simulations. Finally we show that heterogeneous networks maximise the information flow in large-scale networks, through recurrent connections. We conclude that neuronal heterogeneity confers different responsiveness to neural networks, which should be taken into account to investigate their information processing capabilities.
Leaf surface characteristics affect the deposition and distribution of droplets in rice (Oryza sativa L.)
Authors: Ji Guangmei , Chen Huizhe , Zhang Yuping , Xiang Jing , Wang Yaliang , Wang Zhigang , Zhu Defeng , Zhang Yikai
Published: September 2021

We studied the effects of leaf surface characteristics on canopy droplet behaviour using two rice cultivars with similar leaf shapes but significantly different leaf surface characteristics: Jia58 (glabrous rice; smooth leaf surface and no burrs) and Yongyou12 (hairy-leaved rice; rough leaf surface covered with burrs). The plants were subjected to spray tests with different spray pressures and nozzle apertures. The results showed that the deposition amount per unit leaf area was significantly higher in the Yongyou12 canopy than in the Jia58 canopy. The diameter, volume median diameter, number median diameter, and coverage of droplets were significantly higher in Yongyou12 than in Jia58, while the coverage density of droplets was significantly lower. The proportion of small droplets of Jia58 is higher than that of Yongyou12. Thus, a larger amount of large-sized droplets could retain on the leaf surface of hairy-leaved rice, and a larger number of small-sized droplets were retained on the leaf surface of glabrous rice. Smaller pressure and larger flow nozzle were conducive to the retention of the Jia58, while Yongyou12 required larger pressure and larger flow nozzles. Ultrastructural analyses revealed that the leaf surface of glabrous rice had no trichomes and more wax than hairy-leaved rice, and the critical surface tension was lower, resulting in the retention of mainly small droplets on its leaf surface and a lower deposition amount. Therefore, in order to increase the deposition of pesticide droplets on the leaf surface in production, glabrous rice should choose nozzles with smaller spray pressure and large flow rate.
Regular intake of energy drinks and multivitamin supplements is associated with elevated plasma vitamin B6 levels in post-bariatric patients
Authors: Tynes Martina , Hepprich Matthias , Timper Katharina
Published: September 2021

The aim of the present survey was to analyze plasma vitamin B6 levels in post-bariatric patients and to elucidate the causal factors associated with elevated plasma vitamin B6 levels. This is a retrospective analysis of electronic patient data of all post-bariatric patients evaluated at the endocrine outpatient clinic of the University Hospital Basel in 2017, for which plasma vitamin B6 values were assessed during regular follow-up visits. In total, 205 patients were included in the study, whereof a minority of 43% had vitamin B6 levels in the normal range. 50% of the patients had vitamin B6 levels up to fourfold higher than the upper normal limit and 7% had levels more than fourfold above the upper normal limit. Vitamin B6 deficiency was not observed in any patient. While multivitamin supplementation in general was associated with elevated plasma vitamin B6 levels, the highest vitamin B6 levels were found after biliopancreatic diversion (BPD) and in patients who reported daily energy drink intake. Elevated plasma vitamin B6 levels up to fourfold above the upper normal limit are common in postbariatric patients and are associated with regular multivitamin supplementation, while highly elevated plasma vitamin B6 levels were seen primarily upon regular energy drink intake. Thus, a regular follow-up of vitamin B6 plasma levels and critical evaluation of vitamin B6 supplementation, either as part of the multivitamin preparation or related to regular energy drink intake, is highly warranted and should be an integral part of the routine post-bariatric follow-up.
Effect of ultrasonic surface deep rolling combined with oxygen boost diffusion treatment on fatigue properties of pure titanium
Authors: Teng Xue-Fei , Jia Yun-Fei , Gong Cong-Yang , Zhang Cheng-Cheng , Zhang Xian-Cheng , Tu Shan-Tung
Published: September 2021

Ultrasonic surface deep rolling (USDR), oxygen boost diffusion (OBD), and their combination (USDR-OBD) were all used to improve the surface hardening of pure titanium. The microstructure, microhardness, and fatigue life of pure titanium treated by USDR, OBD, and USDR-OBD methods were analyzed. USDR treatment induced a severe deformation area, while OBD treatment produced a brittle oxygen diffusion zone. The USDR-OBD treated samples approached the highest hardness in comparison with other treated samples. The fatigue lives of USDR treated samples were improved, which was due to the high compressive residual stress and refined grains. However, the fatigue lives of both OBD treated samples and USDR-OBD treated samples were decreased due to premature crack initiation and rapid propagation in the oxygen diffusion zone. Finally, the fatigue fracture mechanisms of different samples were proposed.
Sex related differences in nonmotor symptoms of patients with idiopathic blepharospasm
Authors: Yang Jing , Zhang Lingyu , Hou Yanbing , Wei Qianqian , Ou Ruwei , Lin Junyu , Song Wei , Cao Bei , Shang Huifang
Published: September 2021

Idiopathic blepharospasm shows a female predominance in prevalence, whether there are sex-related differences in distributions of nonmotor symptoms (NMSs) and predictors of quality of life are unknown. Four hundred and twenty-five patients with idiopathic blepharospasm were consecutively recruited, and underwent assessments including dystonia severity, mood disturbances, sleep disturbances, cognition, ocular symptoms, and quality of life. Frequencies and distributions of NMSs, and predictors of quality of life in female and male patients were investigated. NMSs existed in majority of male (94.0%) and female (95.8%) patients. The frequencies of depression, cognition dysfunction, and poor sleep quality were higher in female patients, while the frequency of excessive daytime sleepiness was higher in male patients. More female (79.5%) patients had multiple NMS domains affected than male (70.1%) patients (p = 0.040). Quality of life was associated with depression, anxiety and motor severity for female patients (adjusted R2 = 0.367, p < 0.001), while associated with depression, excessive daytime sleepiness and motor severity for male patients (adjusted R2 = 0.430, p < 0.001). The highly prevalent coexistence of multiple NMSs found in patients with blepharospasm support that blepharospasm is a network disorder. The sex-related differences in the pattern of NMSs and predictors of quality of life may aid the development of tailored management of blepharospasm.
Prediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment OCT angiography
Authors: Okamoto Yoko , Akagi Tadamichi , Kameda Takanori , Suda Kenji , Miyake Masahiro , Ikeda Hanako Ohashi , Numa Shogo , Kadomoto Shin , Uji Akihito , Tsujikawa Akitaka
Published: September 2021

We performed a prospective, longitudinal study to investigate the association between the preoperative intrascleral vasculature assessed using anterior segment (AS)-optical coherence tomography angiography (OCTA) and surgical outcomes of trabecular meshwork-targeted micro- or minimally invasive glaucoma surgery (MIGS). We included 37 patients with primary open-angle glaucoma. Preoperative AS-OCTA images of the sclero-conjunctiva of the nasal corneal limbus were acquired in the superficial (conjunctival) and deep (intrascleral) layers. The vessel densities (VDs) of each layer were measured separately in the entire area, limbal side, and fornix area. Surgical success was determined by postoperative intraocular pressure (IOP) and IOP reduction. Twenty-three and 14 eyes were classified as having successful and unsuccessful outcomes, respectively. The deep VDs of the entire area and fornix area were significantly lower in the successful group (P = 0.031 and P = 0.009). The success rate was significantly higher for eyes with a lower deep VD than for eyes with a higher deep VD. A greater IOP reduction was significantly associated with lower deep VD in the fornix area (P = 0.022) and higher preoperative IOP (P < 0.001). These results indicate that intrascleral vasculature assessed using preoperative AS-OCTA was negatively correlated with surgical success and IOP reduction resulting from trabecular meshwork-targeted MIGS. AS-OCTA images might help predict MIGS outcomes.
RETRACTED ARTICLE: Neutrosophic statistical test for counts in climatology
Authors: Aslam Muhammad
Published: September 2021

The existing F-test for two counts data from the Poisson distribution under classical statistics can be applied only when the counts in the data are exact or not intervals. The existing test cannot be applied when the count data is indeterminate, in the interval, and uncertain. In this paper, the F-test for two counts data from the Poisson distribution under classical statistics is designed. The test for two counts recording at the same time or different times is presented. The daily and the monthly number of records broken data in the U.S from the weather department is selected for the application of the proposed test. The application and comparison studies show the efficiency of the proposed test. The proposed test was found to be informative, flexible, and appropriate to be applied in an uncertain environment.
Origin of the enhanced Nb3Sn performance by combined Hf and Ta doping
Authors: Tarantini Chiara , Kametani Fumitake , Balachandran Shreyas , Heald Steve M. , Wheatley Laura , Grovenor Chris R. M. , Moody Michael P. , Su Yi-Feng , Lee Peter J. , Larbalestier David C.
Published: September 2021

In recent years there has been an increasing effort in improving the performance of Nb3Sn for high-field applications, in particular for the fabrication of conductors suitable for the realization of the Future Circular Collider (FCC) at CERN. This challenging task has led to the investigation of new routes to advance the high-field pinning properties, the irreversibility and the upper critical fields (HIrr and Hc2, respectively). The effect of hafnium addition to the standard Nb-4Ta alloy has been recently demonstrated to be particularly promising and, in this paper, we investigate the origins of the observed improvements of the superconducting properties. Electron microscopy, Extended X-ray Absorption Fine Structure Spectroscopy (EXAFS) and Atom Probe Tomography (APT) characterization clearly show that, in presence of oxygen, both fine Nb3Sn grains and HfO2 nanoparticles form. Although EXAFS is unable to detect significant amounts of Hf in the A15 structure, APT does indeed reveal some residual intragrain metallic Hf. To investigate the layer properties in more detail, we created a microbridge from a thin lamella extracted by Focused Ion Beam (FIB) and measured the transport properties of Ta-Hf-doped Nb3Sn. Hc2(0) is enhanced to 30.8 T by the introduction of Hf, ~ 1 T higher than those of only Ta-doped Nb3Sn, and, even more importantly the position of the pinning force maximum exceeds 6 T, against the typical ~ 4.5–4.7 T of the only Ta-doped material. These results show that the improvements generated by Hf addition can significantly enhance the high-field performance, bringing Nb3Sn closer to the requirements necessary for FCC realization.
Sitagliptin attenuates arterial calcification by downregulating oxidative stress-induced receptor for advanced glycation end products in LDLR knockout mice
Authors: Lin Chih-Pei , Huang Po-Hsun , Chen Chi-Yu , Wu Meng-Yu , Chen Jia-Shiong , Chen Jaw-Wen , Lin Shing-Jong
Published: September 2021

Diabetes is a complex disease characterized by hyperglycemia, dyslipidemia, and insulin resistance. Plasma advanced glycation end products (AGEs) activated the receptor for advanced glycation end products (RAGE) and the activation of RAGE is implicated to be the pathogenesis of type 2 diabetic mellitus (T2DM) patient vascular complications. Sitagliptin, a dipeptidyl peptidase-4 (DPP4) inhibitor, is a new oral hypoglycemic agent for the treatment of T2DM. However, the beneficial effects on vascular calcification remain unclear. In this study, we used a high-fat diet (HFD)-fed low-density lipoprotein receptor deficiency (LDLR−/−) mice model to investigate the potential effects of sitagliptin on HFD-induced arterial calcification. Mice were randomly divided into 3 groups: (1) normal diet group, (2) HFD group and (3) HFD + sitagliptin group. After 24 weeks treatment, we collected the blood for chemistry parameters and DPP4 activity measurement, and harvested the aorta to evaluate calcification using immunohistochemistry and calcium content. To determine the effects of sitagliptin, tumor necrosis factor (TNF)-α combined with S100A12 was used to induce oxidative stress, activation of nicotinamide adenine dinucleotide phosphate (NADPH), up-regulation of bone markers and RAGE expression, and cell calcium deposition on human aortic smooth muscle cells (HASMCs). We found that sitagliptin effectively blunted the HFD-induced artery calcification and significantly lowered the levels of fasting serum glucose, triglyceride (TG), nitrotyrosine and TNF-α, decreased the calcium deposits, and reduced arterial calcification. In an in-vitro study, both S100A12 and TNF-α stimulated RAGE expression and cellular calcium deposits in HASMCs. The potency of S100A12 on HASMCs was amplified by the presence of TNF-α. Sitagliptin and Apocynin (APO), an NADPH oxidase inhibitor, inhibited the TNF-α + S100A12-induced NADPH oxidase and nuclear factor (NF)-κB activation, cellular oxidative stress, RAGE expression, osteo transcription factors expression and calcium deposition. In addition, treatment with sitagliptin, knockdown of RAGE or TNF-α receptor blunted the TNF-α + S100A12-induced RAGE expression. Our findings suggest that sitagliptin may suppress the initiation and progression of arterial calcification by inhibiting the activation of NADPH oxidase and NF-κB, followed by decreasing the expression of RAGE.
Novel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract
Authors: Hoang Hien Thi , Van Tran Vinh , Bui Vu Khac Hoang , Kwon Oh-Hyeok , Moon Ju-Young , Lee Young-Chul
Published: September 2021

The high antimicrobial ability and low toxicity of zinc-aminoclay (ZnAC) are claimed in our previous reports. In this study, we formulate a novel hand gel based on ZnAC and Opuntia humifusa (O. humifusa) extract, which is a high moisturizing agent. The antimicrobial activity, cytotoxicity, moisturizing effect, and clinical skin irritation of the hand gel are evaluated. The hand gel with 0.5 wt.% ZnAC and 1.0 v/v% O. humifusa extract can kill more than 99% Escherichia coli (gram-negative bacteria) and Staphylococcus aureus (gram-positive bacteria) after 24 h. Toxicity evaluation shows that, the hand gel does not affect the viability of mammalian HaCaT cells. Additionally, skin moisture is increased by applying the hand gel while its viscosity is at the standard level of commercial products. The hand gel has a skin irritation index of 0.0 and is classified as a non-irritating product. We successfully formulated hand gel from ZnAC, glucomannan, glycerol, and O. humifusa extract. Owing to the high antimicrobial activity and skin protection of hand gels, they are suitable to be used as hand sanitizers in restaurants, hospitals, and homes effectively.
The prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database
Authors: Wei Haibin , Miao Jia , Cui Jianxin , Zheng Wei , Chen Xinpeng , Zhang Qi , Liu Feng , Mao Zujie , Qiu Songlin , Zhang Dahong
Published: September 2021

Existing data on the prognosis and clinicopathological features of patients with metastatic renal cell carcinoma (mRCC) are limited. This study aims to investigate the prognostic value and clinicopathological features of different metastatic sites in patients with mRCC. A dataset from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database consisting of 18 registries (1973–2015) was selected for a retrospective mRCC cohort study. Information was included on the metastatic sites in lung, bone, liver, and brain. Kaplan–Meier analysis was applied to compare the survival distribution. Univariate and multivariate Cox regression models were used to analyze survival outcomes. From the SEER database, a total of 10,410 patients with primary mRCC from 2010 to 2015 were enrolled in this cohort study. Analysis indicated that 54.9%, 37.7%, 19.5%, and 10.4% of patients were found to have lung, bone, liver, and brain metastasis, respectively. There was a significantly higher risk for sarcomatoid RCC patients to develop liver metastasis as compared to patients with clear cell RCC. The median survival for patients with lung, bone, liver, or brain metastasis was 7 months, 7 months, 4 months, and 5 months, respectively. Various clinicopathological features and prognostic values are associated with different metastatic sites. Understanding these differences may enable targeted pre-treatment assessment of primary mRCC and personalized curative intervention for patients.
Ultralow-noise microwave extraction from optical frequency combs using photocurrent pulse shaping with balanced photodetection
Authors: Hyun Minji , Jeon Chan-Gi , Kim Jungwon
Published: September 2021

The phase noise of microwaves extracted from optical frequency combs is fundamentally limited by thermal and shot noise, which is inherent in photodetection. Saturation of a photodiode due to the high peak power of ultrashort optical pulses, however, prohibits further scaling of white phase noise by increasing incident optical power. Here we demonstrate that the photocurrent pulse shaping via balanced photodetection, which is accomplished by replacing a single photodiode with a balanced photodetector (BPD) and delaying one of the optical pulses, provides a simple and efficient optical-to-electrical interface to increase achievable microwave power and reduces the corresponding thermal noise-limited phase noise by 6-dB. By analysing contributing noise sources, we also show that the thermal noise floor can reach − 166 dBc/Hz even at a low photocurrent of 2-mA (4-mW optical input per photodiode) when using a p-i-n BPD. This finding may be useful for on-chip microwave generation, which consists of standard p-i-n structure photodiodes with relatively low saturation optical power.
Applications of Cattaneo–Christov fluxes on modelling the boundary value problem of Prandtl fluid comprising variable properties
Authors: Nazir Umar , Sohail Muhammad , Ali Umair , Sherif El-Sayed M. , Park Choonkil , Lee Jung Rye , Selim Mahmoud M. , Thounthong Phatiphat
Published: September 2021

Stretched flows have numerous applications in different industrial, biomedical and engineering processes. Current research is conducted to examine the flow phenomenon of Prandtl fluid model over a moveable surface. The phenomenon of mass and thermal transportation is based on generalized theory of Cattaneo–Christov which considers the involvement of relaxation times. In addition to these, variable characteristics of thermal conductivity and diffusion coefficient are considered as a function of temperature. The physical problem in Cartesian coordinate system is modeled via boundary layer theory which yields a coupled system of partial differential equations. Group scaling transportation is applied to model these PDEs system. The converted equations have been approximated via optimal homotopic scheme. The efficiency and validity of used approach has been shown by computing the error analysis and establishing a comparative study. It is noted that the enhancement in magnetic parameter plays a controlling role for velocity field and it augment the concentration and temperature fields. Furthermore, increase in thermal relaxation parameter and Prandtl number maintains the fluid temperature.
Whole-genome association study searching for QTL for Aeromonas salmonicida resistance in rainbow trout
Authors: Marana Moonika H. , Karami Asma M. , Ødegård Jørgen , Zuo Shaozhi , Jaafar Rzgar M. , Mathiessen Heidi , von Gersdorff Jørgensen Louise , Kania Per W. , Dalsgaard Inger , Nielsen Torben , Buchmann Kurt
Published: September 2021

Aeromonas salmonicida subsp. salmonicida, the causative agent of furunculosis, has extensive negative effects on wild and farmed salmonids worldwide. Vaccination induces some protection under certain conditions but disease outbreaks occur even in vaccinated fish. Therefore, alternative disease control approaches are required to ensure the sustainable expansion of rainbow trout aquaculture. Selective breeding can be applied to enhance host resistance to pathogens. The present work used genome-wide association study (GWAS) to identify quantitative trait loci (QTL) associated with A. salmonicida resistance in rainbow trout. A total 798 rainbow trout exposed to A. salmonicida by bath challenge revealed 614 susceptible and 138 resistant fish. Genotyping was conducted using the 57 K single nucleotide polymorphism (SNP) array and the GWAS was performed for survival and time to death phenotypes. We identified a QTL on chromosome 16 and located positional candidate genes in the proximity of the most significant SNPs. In addition, samples from exposed fish were examined for expression of 24 immune-relevant genes indicating a systematic immune response to the infection. The present work demonstrated that resistance to A. salmonicida is moderately heritable with oligogenic architecture. These result will be useful for the future breeding programs for improving the natural resistance of rainbow trout against furunculosis.
Identification of distinct tumor cell populations and key genetic mechanisms through single cell sequencing in hepatoblastoma
Authors: Bondoc Alexander , Glaser Kathryn , Jin Kang , Lake Charissa , Cairo Stefano , Geller James , Tiao Gregory , Aronow Bruce
Published: September 2021

Hepatoblastoma (HB) is the most common primary liver malignancy of childhood, and molecular investigations are limited and effective treatment options for chemoresistant disease are lacking. There is a knowledge gap in the investigation of key driver cells of HB in tumor. Here we show single cell ribonucleic acid sequencing (scRNAseq) analysis of human tumor, background liver, and patient derived xenograft (PDX) to demonstrate gene expression patterns within tumor and to identify intratumor cell subtype heterogeneity to define differing roles in pathogenesis based on intracellular signaling in pediatric HB. We have identified a driver tumor cell cluster in HB by genetic expression which can be examined to define disease mechanism and treatments. Identification of both critical mechanistic pathways combined with unique cell populations provide the basis for discovery and investigation of novel treatment strategies in vitro and in vivo.
In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance
Authors: Shan Lu , Dyk Nydia Van , Haskins Nantaporn , Cook Kimberly M. , Rosenthal Kim L. , Mazor Ronit , Dragulin-Otto Sonia , Jiang Yu , Wu Herren , Dall’Acqua William F. , Borrok Martin J. , Damschroder Melissa M. , Oganesyan Vaheh
Published: September 2021

In a biologic therapeutic landscape that requires versatility in targeting specificity, valency and half-life modulation, the monomeric Fc fusion platform holds exciting potential for the creation of a class of monovalent protein therapeutics that includes fusion proteins and bispecific targeting molecules. Here we report a structure-guided approach to engineer monomeric Fc molecules to adapt multiple versions of half-life extension modifications. Co-crystal structures of these monomeric Fc variants with Fc neonatal receptor (FcRn) shed light into the binding interactions that could serve as a guide for engineering the half-life of antibody Fc fragments. These engineered monomeric Fc molecules also enabled the generation of a novel monovalent bispecific molecular design, which translated the FcRn binding enhancement to improvement of in vivo serum half-life.
Hydrophobicity-switchable deep eutectic solvent-based effervescence-assisted dispersive liquid–liquid microextraction with solidification of floating droplets for HPLC determination of anthraquinones in fried Cassiae semen tea infusions
Authors: Shi Zhihong , Li Xinye , Tian Yuehong , Fan Yuanyuan , Liu Junjie , Zhang Hongyi
Published: September 2021

HSDES-EA-DLLME-SFD for HPLC determination of anthraquinones in Cassiae semen tea infusions.
Copper adhesive tape attached to the reverse side of a non-conductive glass slide to achieve protein MALDI-imaging in FFPE-tissue sections
Authors: Wu Ran , Qin Liang , Chen Lulu , Ma Rui , Chen Difan , Liu Haiqiang , Xu Hualei , Guo Hua , Zhou Yijun , Wang Xiaodong
Published: September 2021

Copper adhesive tape attached to reverse side of non-conductive glass slide was successfully developed as a new approach to achieve protein MALDI-imaging in FFPE-tissue sections.
A metal-porphyrinic framework film as an efficient optical limiting layer in an electro-optical switchable device
Authors: Lei Song , Chang Li-Mei , Gu Zhi-Gang , Zhang Jian
Published: September 2021

Herein we report a 2D surface-coordinated porphyrinic metal–organic framework film (SURMOF) CuTCPP prepared by a layer by layer method as an optical limiting layer in a polymer-dispersed liquid crystal (PDLC) device.