bluuebunny/crossref_metadata_2025 huggingface dataset:
Os sentidos e significados das práticas pedagógicas no uso da música e da dança na educação infantil
Authors: Silva Jéssica Maria dos Santos , Nascimento Pedro Antonio Santos do , Braga Osmar Rufino
Published: February 2023

O artigo, que é resultado de uma pesquisa realizada em 2020, junto a uma escola de educação infantil, situada no município de Parnaíba (PI), tem como objetivo apresentar uma análise acerca dos sentidos e significados das práticas pedagógicas, desenvolvidas por educadores, que trabalham com a música e a dança na escola de educação infantil. O estudo qualitativo, usou uma abordagem metodológica do tipo etnográfico. O trabalho situa-se no contexto das investigações acerca da educação infantil, com destaque para um tema que está ligado ao eixo temático da cultura, linguagem e interação social. As conclusões das análises apontam para a existência de concepções e práticas que focalizam a música e a dança apenas como instrumento de relaxamento, forma de entretenimento, “quebra gelo” e artifício e não como dispositivos centrais e estratégicos no desenvolvimento integral da criança.
Principais complicações pós-transplante hepático: uma revisão integrativa de literatura
Authors: Gomes Maria Jacilene de Araújo , Rosa Francisca Rafaela Pereira de Amorim Castro , Cunha Iane Andrade Maciel Feldner , Faria Raquel Santos Berto de
Published: February 2023

As complicações vasculares permanecem como causa importante de morbidade, mortalidade e perda de enxerto pós-transplante, sendo a trombose da artéria hepática a mais comum e suas manifestações variam desde ausência de sintomas até a ocorrência de choque séptico secundário à gangrena hepática fulminante. A infecção ainda é a principal causa de morte após transplante hepático, ocorrendo na maioria dos casos, no primeiro mês após a cirurgia. As complicações biliares também são causas comuns de morbidade e mortalidade após transplante hepático, e que sua elevada taxa de incidência deve-se a vários fatores, incluindo isquemia das vias biliares, imunossupressão, transplante entre indivíduos do grupo sanguíneo ABO incompatíveis, infecção pelo citomegalovírus e fatores técnicos. Já as complicações pós-operatórias imediatas podem incluir sangramento, infecção, rejeição, drenagem biliar alterada, deiscência, trombose vascular, coagulopatia, hipertensão portal, fibrinólise, hipotensão, hipertensão, disfunção renal, alterações psicológicas, entre outras. A mielinólise pontina central (MPC) - desmielinização não-inflamatória, frequentemente simétrica, concentrada no centro da ponte - tem incidência baixa em receptores de fígado, mas alta incidência de mortalidade.
Perancangan logo produk pada usaha mikro kecil dan menengah di Kabupaten Bogor
Authors: Febriani Elfira , Yojana Ratna Mira , Hetharia Dorina , Rambung Richard A.
Published: February 2023

Dodol merupakan panganan manis tradisional khas Indonesia yang terbuat dari santan kelapa, tepung ketan dan gula merah. UMKM Asri Dodol merupakan salah satu UMKM yang menghasilkan dodol di Kec. Bojonggede, Bogor melalui proses yang masih tradisional dan tergolong industri rumahan. Permasalahan yang dialami adalah logo produk pada kemasan saat ini kurang menarik dan tidak terlihat dengan jelas. Pemilik belum memahami bahwa logo menjadi salah satu hal penting untuk menarik para konsumen. Oleh karena itu UMKM ini membutuhkan perancangan logo untuk menarik konsumen. Metode pelaksanaan kegiatan ini adalah melalui wawancara dan kunjungan ke lokasi mereka. Desain logo yang diberikan ada dua alternatif dimana masing-masing alternatif logo dirancang dengan desain yang menarik dari sisi warna, tulisan, maupun gambar. UMKM Asri Dodol memilih desain dua karena memiliki warna dan bentuk yang lebih menarik. Keberhasilan dari kegiatan ini dapat dilihat dari bertambahnya pengetahuan UMKM mengenai pentingnya logo dan adanya desain logo baru yang diberikan kepada UMKM Asri Dodol untuk digunakan kedepannya. Pendampingan masih perlu dilanjutkan untuk membantu UMKM dapat bersaing dengan pesaing lokal lain dari seluruh Indonesia.
Peningkatan keahlian guru membuat media pembelajaran fisika interaktif berorientasi keterampilan problem-solving melalui quizizz-web
Authors: Mufida Shobrina Nurul , Hegarna Rona , Safitri Indah , Merliana Lina , Rizky Aang Rifqi , Iryanti Mimin
Published: February 2023

Penggunaan teknologi semakin maju sehingga dunia pendidikan harus mengikuti adanya perkembangan tersebut, terutama dalam menunjang keterampilan abad-21 siswa salah satunya keterampilan problem-solving. Penelitian ini bertujuan untuk mendeskripsikan pengaruh WEBIMLAT terhadap keahlian guru fisika membuat media pembelajaran interaktif berorientasi keterampilan problem solving melalui Quizizz-web. Penelitian ini melibatkan total 27 guru fisika dari berbagai provinsi di Indonesia. Kegiatan WEBIMLAT ini terdiri dari beberapa tahap, yaitu Webinar, Pelatihan, Pendampingan dan Bimbingan. Guru-guru fisika sebagai peserta pelatihan menunjukkan bebapa capaian, yaitu: a) peserta mampu merancang media pembelajaran interaktif dengan memanfaatkan platform Quizizz-web untuk melatihkan keterampilan problem-solving siswa, b) peserta mampu membuat media presentasi berorientasi keterampilan problem-solving, dan c) peserta merasa memiliki pengetahuan terkait cara menyusun soal evaluasi yang memuat indikator physics problem-solving. Melalui kegiatan WEBIMLAT ini keahlian guru dalam membuat pembelajaran interaktif untuk melatih keterampilan problem-solving siswa mengalami peningkatan dan sangat berkembang.
Cara memasarkan produk UMKM pada masa COVID-19 melalui media sosial
Authors: Widiawati Kadek , Kalfika Anggria Wardani Kadek Devi , Supriyadinata Gorda A.A. Ngr. Eddy
Published: February 2023

Melemahnya ekonomi karena adanya pandemi COVID-19 dapat berdampak langsung terhadap UMKM Roti yang ada di Desa Padangsambian, Kecamatan Denpasar Barat. Hal tersebut menyebabkan permintaan dan pendapatan berkurang. Solusi yang dapat dilakukan untuk mengatasi permasalahan tersebut dengan memberikan edukasi dan pelatihan terkait dengan penggunaan dan pembuatan akun digital marketingsebagai alat untuk memasarkan produk UKM Roti di Desa Padangsambian. Edukasi yang diberikan berupa pelatihan mengenai cara memasarkan produk di media social, e-commerce, dan website dengan tepat dan benar. Program lain yang diberikan yaitu dengan asistensi pembuatan akun e-commerce dan digital marketingyang lainnya yang akan digunakan untuk promosi.Platform yang dipilih yaitu media yang memiliki jejaring pengguna besar di Indonesia, yaitu Facebook, Intagram, dan Shopee Food. Metode yang digunakan dalam kegiatan ini adalah pelatihan dan pendampingan. Hasil dari kegiatan ini adalahÂ  terbentuknya akun digital marketingseperti Facebook, Instagram, dan juga Shopee Food yang digunakan untuk mempromosikan hasil produksi dari UMKM Roti sehingga dapat meningkatkan pendapatan penjualan hasil produksi, hasil pengabdian ini sangat bermanfaat bagi UMKM Roti untuk mempertahankan usahanya di tengah pandemi COVID-19 saat ini. Sebagai tindak lanjut, diharapkan pemerintah desa setempat bekerja sama dengan pihak ketiga memberikan pelatihan pembuatan konten marketing, sehingga akun yang telah dibuat dapat dimaksimalkan untuk memasarkan produk UKM Roti.
Optimalisasi website badan usaha milik desa dilingkup kabupaten berbasis literasi digital
Authors: Shobaruddin Muhammad , Hendrawan Muhammad Rosyihan , Putra Endry
Published: February 2023

Kegiatan Pengabdian Kepada Masyarakat (PKM) yang bertajuk FIA UB Mengabdi ini menyoroti bagaimana BUMDes dan pengelolaan informasi di wilayah Kabupaten Malang mampu menjalankan sektor perekonomian ketika masa pandemi COVID-19 terjadi. Dalam rangka mengkhususkan sasaran FIA UB Mengabdi dan mempertajam analisis tentang pembahasan literasi digital, berikut juga kesejahteraan masyarakat Desa Sumbersekar, maka arah kegiatan FIA UB mengabdi memfokuskan pada pendekatan literasi digital khususnya manajemen website desa. Dikarenakan Tim PKM melanjutkan Program Inisiasi Kampung Literasi yang menjadi binaan FIA UB dan digagas sejak tahun 2020 silam. Pengabdian ini menggunakan pendekatan Asset Based Based Community Development dengan mengenali potensi, tantangan dan peluang. Tujuan akhir dari program pengabdian masyarakat ini adalah peningkatan pemahaman dan perubahan perilaku masyarakat melalui pendekatan kognitif. Perilaku yang diharapkan berkaitan dengan kesadaran berinovasi terkait pengelolaan BUMDes berbasis literasi digital dalam hal ini dimanifestasikan oleh website resmi Desa Sumbersekar. Perubahan perilaku dan peningkatan pemahaman yang dimaksud tidak bisa terjadi secara instan, oleh karena itu diperlukan komitmen dan konsistensi dalam melakukan program ini. Tindak lanjut kesadaran dari akademisi dan masyarakat untuk memiliki keinginan belajar mengenai pengelolaan website baik secara mandiri maupun berkelompok.
Teknologi porang bulb chopper machine with 2 hoppers sebagai upaya penurunan biaya produksi chip porang
Authors: Tinta Dadick Ardian , Gumiwang Fizar Candra , Andriyani Bela , Nasori Imam , Rimbita Trismi , Pamuji Dian Ridlo , Yuniwati Ika
Published: February 2023

Umbi Porang merupakan salah satu komoditas ekspor di Indonesia. Masing-masing wilayah di Indonesia bersaing untuk melakukan penanaman porang. Salah satu Kelompok tani Desa Kembiritan Banyuwangi merupakan penghasil umbi porang. Kelompok tani memanen umbi porang dan mengolahnya setelah itu dikirimkan ke berbagai kota yang ada di dalam negeri maupun ke luar negeri dalam bentuk chips porang karena memiliki harga jual yang cukup tinggi. Minimnya pengetahuan masyarakat terhadap teknologi untuk pengolahan tanaman porang menjadi chips porang mengakibatkan produktivitas chips porang kurang maksimal. Hal itu juga menyebabkan biaya produksi semakin tinggi. Berdasarkan permasalahan tersebut, dibutuhkan sebuah penerapan IPTEK untuk mengatasi masalah kurang optimalnya produktivitas chips porang. Proses penanganan pasca panen yang cepat dan benar dapat menghasilkan chips yang mempunyai mutu baik, mengurangi kehilangan bobot, mengurangi nilai kamba, dan memperpanjang umur simpan. Penerapan teknologi Porang Bulb Chopper Machine With 2 Hoppers diawali dengan penyesuaian teknologi dengan kebutuhan mitra kemudian dilakukan tahap analisa dan evaluasi teknologi. Hasil dari evaluasi dengan menggunakan penerapan teknologi tersebut 55%.
TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS
Authors: DOĞAN Muhammed Fatih , ÇİFTÇİ Oisman , BAŞAK TÜRKMEN Neşe , ÇETİN Aslı , ZENGİN Münevver Nazlıcan , ÇİFTÇİ Bedriye
Published: February 2023

Objective: The aim of the study was to investigate the preventive effects of Taurine against 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)-induced organ damage in rats. The environmental toxin TCDD has a high toxicity in animal and human tissues. Taurine is an amino acid found in organ cells that has and antioxidant properties and anti-inflammatory. As a result, the potential preventive effect of taurine on oxidative stress and organ damage caused by TCDD was investigated in rat liver and kidney tissues by measuring glutathione (GSH), superoxide dismutase (SOD) activity, and thiobarbituric acid reactive substances (TBARS) levels.

Material and Method: Adult male Wistar rats (250-300 g, 12-13 weeks, n = 32) were randomly allocted into four groups (n = 8/group): Control, TCDD, TAU, and TCDD+TAU. TCDD and/or taurine were administered via gavage in doses of 2 μg/kg/week and 200 mg/kg/day, respectively.

Result and Discussion: The results showed that TCDD caused oxidative stress in the liver and kidney tissues of rats by decreasing the levels of GSH and SOD activity and increasing the levels of TBARS. Taurine treatment significantly reduced TBARS levels (p
DEVELOPMENT AND OPTIMIZATION OF INDOMETHACIN NANOSUSPENSIONS USING DESIGN OF EXPERIMENT APPROACHES
Authors: TOPAL Gizem Rüya , KÖSE ÖZKAN Cansel , ÖZKAN Yalçın
Published: February 2023

ABSTRACT

Objective: In this study, it was aimed to prepare nanosuspensions that contains Indomethacin which is a BCS class II drug. To assess the cumulative impact of the chosen variables on the nanosuspension properties, a 34 factorial design was applied and particle size and distributions were examined.

Material and Method: In the study, the solvent/antisolvent method was used in the preparation of the suspensions. 34 factorial design. Design-Expert software was used for evaluation of the prepared formulations in order to obtain the best formulation. PVA ratio, PVA molecular weight, solvent/antisolvent ratio, and ethanol/PEG ratio were used as independent design parameters, and their effects on particle size and distribution were examined.

Result and Discussion: Nanosuspensions were successfully prepared by the solvent/antisolvent method. Particle size and polydispersity index of the nanosuspensions were found to be affected by both molecular weight and percentage of PVA in the anti-solvent phase (p ˂ 0.05). 0.2% PVA; molecular weight of 31 000 for PVA and the solvent-antisolvent ratio as 3:50 were found to be the optimal parameters for the nanosuspension formulations. The particle size and polydispersity of optimum formulation was found 301.5 ± 31.1 nm and 0.159 ± 0.035, respectively.

Keywords: Factorial design, indomethacin, nanosuspension, solvent/antisolvent method
RPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS DETERMINATION OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS IN TABLET FORMULATIONS
Authors: ÇUBUK DEMİRALAY Ebru , ÜRER Fatma , ÜSTÜN Zehra , DALDAL Yaşar Doğan
Published: February 2023

Objective: Selective serotonin reuptake inhibitor (SSRIs) compounds are the most used compounds in the treatment of depression. The determination of chromatographic separation and quantitative determination of these compounds is very important in the clinical use of these compounds and the success of biopharmaceutical studies. For this reason, this study, it was aimed to optimize the chromatographic conditions for the quantitative determination of SSRIs in tablet formulation by Reversed phase liquid chromatography method.

Material and Method: The optimum separation condition for the studied compounds was determined based on the relationship between the retention values of the compounds and the pH and the content of the mobile phase. Chromatographic determination was made on the X Terra C18 column (250 x 4.6 mm I.D., 5 μm), which is widely used for the determination of hybrid-based and basic compounds. The validation of the developed method was carried out based on the parameters of linearity, precision, and accuracy.

Result and Discussion: The developed and validated method was successfully applied for the determination of active ingredients in the tablet dosage form. The experimental results of the amount of studied SSRIs in selected commercial tablets are in good agreement with the label claims. The calculated percent recoveries show that the sample preparation techniques developed for the quantification of the compounds studied are not affected by interferences. The evaluation of the obtained results showed that the developed method is suitable for the routine use of studied compounds.
Selection of animal models for drug efficacy
Authors:   , Griffioen Désirée Huberta
Published: February 2023

A major hurdle in drug development is the limited benefit of efficacy data in animals for use in the clinic. For each patient (sub)group or disease, many different animal models exist to provide insight into drug efficacy. However, it is often unclear how predictive the outcomes of drugs tested in these models are for the clinic, and on what basis researchers select a specific model. The main goal of this thesis is to gain insight into the selection of animal models for drug efficacy. We studied the extent of the low value of animal models for predicting efficacy. Then, we analyzed underlying causes of this low value. To this end, we studied the role of different stakeholders in the selection process, such as researchers, local and national ethics committees, and funding agencies. Finally, we present an instrument that supports the evaluation of similarities between animal models and patients: the Framework to Identify Models of Disease (FIMD). FIMD provides a solution to assess the value of animal models for efficacy. We applied FIMD to validate two animal models of cow's milk allergy in young children. We demonstrated that the instrument contributes to validating animal models for drug efficacy and thus can facilitate appropriate animal model selection. When applied, this instrument provides a scientific basis for policy recommendations and changes, which can lead to a more responsible use of animals in drug development.
Urgent Start Peritoneal Dialysis: A Viable Option for Acute and Chronic Kidney Failure
Authors: Ponce Daniela , Bittencourt Dias Dayana , Balbi Andre Luis
Published: February 2023

Peritoneal dialysis (PD) may be a feasible, safe, and complementary alternative to haemodialysis, not only in the chronic setting, but also in the acute. Recently, interest in using PD to manage acute kidney injury (AKI) patients has been increasing. Some Brazilian studies have shown that, with careful thought and planning, critically ill patients can be successfully treated with PD. To overcome some of the classic limitations of PD use in AKI, such as a high chance of infectious and mechanical complications, and no control of urea, potassium, and bicarbonate levels, the use of cycles, flexible catheters, and a high volume of dialysis fluid has been proposed. This knowledge can be used in the case of an unplanned start on chronic PD and may be a tool to increase the PD penetration rate among incident patients starting chronic dialysis therapy. PD should be offered in an unbiased way to all patients starting unplanned dialysis, and without contraindications to PD. In the following manuscript, advances in technical aspects and the advantages and limitations of PD will be discussed, and recent literature on clinical experience with PD use in the acute and unplanned setting will be reviewed.
New Dermatological Indications for Pulsed Dye Lasers
Authors: Jiménez Gómez Natalia , Pérez García Bibiana , Boixeda Pablo , Jaén Pedro
Published: February 2023

Laser therapy has been classically focussed on three different chromophores: haemoglobin, melanin, and water, based on selective photothermolysis theory. Despite the fact that therapy is evolving with the introduction of multiple new wavelengths and the description of more therapeutic targets, some laser devices, such as the pulsed dye laser (PDL), are still relevant in our clinical practice. Based on a redefined concept of selective photothermolysis, PDL seems to be a promising tool for the treatment of skin conditions different to vascular lesions. Its role in viral infections, inflammatory diseases (such as acne or systemic lupus erythematosus), scars, and basal cell carcinoma is reviewed in this paper.
REST/NRSF Target Genes in Neuronal and Beta Cells: Pathophysiological and Therapeutic Perspectives for Diabetes and Neurodegenerative Disorders
Authors: Abderrahmani Amar
Published: February 2023

Pancreatic beta and neuronal cells share numerous similarities, including a key transcriptional mechanism of the differentiation programme. The mechanism involves the decrease or the extinction of the transcriptional repressor RE-1-silencing transcription factor (REST), also called neuron-restrictive silencer factor (NRSF), which leads to the expression of various genes encoding proteins required for mature beta and neuronal cell function. Abnormal expression and genetic variation in some of the REST/NRSF target genes have been reported in diabetes and neurodegenerative disorders, suggesting that common pathogenic mechanisms account for beta-cell decline and neuronal degeneration in the two diseases. In addition, some of the REST/NRSF target genes have been identified as potential therapeutic targets for improvement of beta-cell function in diabetes. This review sheds light on the neuronal and beta-cell REST/NRSF target genes that are potential future drug targets for the treatment of diabetes and neurodegeneration.
Utility of Glycated Haemoglobin in Gestational Diabetes Mellitus: Present and Future
Authors: Rajput Rajesh , Jain Deepak
Published: February 2023

Gestational diabetes mellitus (GDM) is a major public health problem with various complexities involved in its diagnosis. Traditionally an oral glucose tolerance test is used for the diagnosis of GDM, however the measurement of plasma glucose values both after fasting and the glucose challenge test has certain shortcomings, especially during pregnancy. The American Diabetes Association (ADA) in 2010 and the World Health Organization (WHO) in 2011 have accepted glycated haemoglobin (HbA1c) as a tool for diagnosing diabetes mellitus, however it is not currently recommended as a diagnostic tool for GDM. The estimation of HbA1c levels is likely to be more acceptable to pregnant women, as a single non-fasting blood sample is required for this investigation. Although various studies have shown different HbA1c cut-off values representing the best equilibrium between sensitivity and specificity for GDM, most of them conclude that an HbA1c level of >5.95% can be used to diagnose GDM in pregnant women with high specificity. This article reviews the present role and future place of measuring HbA1c levels in the diagnosis of GDM.
Achieving Treatment Goals in Inflammatory Bowel Disease: The Role of Gut-Selective Therapy
Authors: Arnstein Lauri
Published: February 2023

Despite major advances in the inflammatory bowel disease (IBD) treatment landscape, the management of ulcerative colitis (UC) and Crohn’s disease (CD) continues to pose challenges. There is significant scope to optimise treatment of IBD, and conventional therapies may fail to meet evolving treatment goals. Induction of remission with clinical control of symptoms and maintenance of remission with long-term prevention of disease progression are important considerations for healthcare professionals. The concept of complete remission integrates clinical remission, patient-reported outcomes, and mucosal healing, a key therapeutic goal for disease modification. The anti-integrin vedolizumab has been proven to be effective in inducing and maintaining clinical remission in IBD, both first-line and in tumour necrosis factor α (TNFα)-experienced patients, and has demonstrated mucosal healing benefits in UC patients. Safety remains critical for all therapies and vedolizumab is generally well-tolerated across all age groups, including the elderly. Real-world experience with vedolizumab has shown broadly comparable outcomes to the pivotal clinical trials.
The Liver Meeting 2014: Summary of Presentations on Genotype 3 HCV Infection from the 65th Annual Liver Meeting of the American Association for the Study of Liver Diseases (AASLD), Held in Boston, MA, USA, on 7th-11th November, 2014
Authors: Charles Caroline
Published: February 2023

After genotype 1 (GT1), genotype 3 (GT3) is the second most common hepatitis C virus (HCV) genotype worldwide, with an estimated worldwide prevalence of 54.3 million. As its high prevalence already represents a significant burden, this genotype appears to be one of the most difficult to treat using all oral therapies, which is of importance as it is associated with more rapid fibrosis progression and disproportionately increased risks of steatosis (fatty liver disease) and hepatocellular carcinoma. Outstanding developments in clinical research in the last few years have led to the development of direct-acting antivirals, but GT3 still represents a challenge yet to be addressed, and is a clear unmet medical need, especially with associated comorbidities (advanced, liver disease, pre and post-transplant patients, HIV/HCV co-infected patients). The 65th American Association for the Study of Liver Diseases Annual Meeting, The Liver Meeting® 2014, took place in Boston, Massachusetts, USA, on 7th–11th November 2014. This review will summarise the highlights of this meeting on the future of GT3 HCV treatment within pivotal clinical trials.
Non-Alcoholic Fatty Liver Disease – Changing the Prevalence of Liver Cancer?
Authors: Campana Benedetta , Semela David , Heim Markus , Bernsmeier Christine
Published: February 2023

Due to its increasing prevalence, exceeding 25% of the Western population, non-alcoholic fatty liver disease (NAFLD) merits recognition as one of the most frequent chronic liver diseases (CLD) and requires consideration of the associated disease-related complications and their consequences for the surveillance and treatment of patients and the socio-economy worldwide. Along with the increasing incidence of NAFLD-related cirrhosis and end-stage liver disease, the frequency of NAFLD-related hepatocellular carcinoma (HCC) is rising and expected to surpass HCC related to chronic hepatitis C in the upcoming future. These epidemiologic changes will impact on the overall mortality of CLD and the requirement of organs for transplantation. Although the risk of HCC in NAFLD, similar to other CLD, is related to fibrosis (advanced fibrosis increases the risk of HCC 25-fold), there are reports suggesting a considerable rate of HCC also developing in simple hepatic steatosis. Moreover, HCC is nowadays the leading cause of obesity-related cancer mortality; cancers of other origin such as colorectal cancer are more prevalent in patients with NAFLD and obesity. The pathophysiology of HCC has mainly been studied in models of viral hepatitis. Given the expected raise in NAFLD-related HCC, a better understanding of the pathophysiology of carcinogenesis in NAFLD and obesity is desired in order to better define chemopreventive strategies. Here we review the epidemiology, aetiology, and pathogenesis of HCC on the background of NAFLD and deduce potential consequences for the management of patients in respect to the NAFLD epidemic.
Secondary Carnitine Deficiency in Dialysis Patients: Shall We Supplement It?
Authors: Phillipson Jackie
Published: February 2023

Carnitine, essential for fatty acid β-oxidation, is obtained from diet and through de novo biosynthesis. The organic cation/carnitine transporter 2 (OCTN2) facilitates carnitine cellular transport and kidney resorption. Carnitine depletion occurs in OCTN2-deficient patients, with serious clinical complications including cardiomyopathy, myopathy, and hypoketotic hypoglycaemia. Neonatal screening can detect OCTN2 deficiency. OCTN2-deficiency is also known as primary carnitine deficiency. Carnitine deficiency may result from fatty acid β-oxidation disorders, which are diagnosed via plasma acylcarnitine profiling, but also under other conditions including haemodialysis. Given the importance of the kidney in maintaining carnitine homeostasis, it is not unexpected that longterm haemodialysis treatment is associated with the development of secondary carnitine deficiency, characterised by low endogenous L-carnitine levels and accumulation of deleterious medium and long- chain acylcarnitines. These alterations in carnitine pool composition have been implicated in a number of dialysis-related disorders, including erythropoietin-resistant renal anaemia. The association between erythropoietin resistance and carnitine levels has been demonstrated, with the proportion of medium and long-chain acylcarnitines within the total plasma carnitine pool positively correlated with erythropoietin resistance. Recent research has demonstrated that carnitine supplementation results in a significant reduction in erythropoietin dose requirements in patients with erythropoietin-resistant anaemia. Few studies have been conducted assessing the treatment of carnitine deficiency and haemodialysisrelated cardiac complications, particularly in children. Thus, a study was recently conducted which showed that intravenous carnitine in children receiving haemodialysis significantly increased plasma carnitine.
The New Taxa of Ferns in the Northeast Section of the Lesser Caucasus
Authors: Verdieva L. , Asgarov A.
Published: February 2023

During the expeditions in the north-eastern part of the Lesser Caucasus in 2014-2016 and based on the results analysis of the collected herbarium and descriptor information three species (Polypodium interjectum Shivas, Polystichum ×illyricum (Borbás) Hahne, Cystopteris anthriscifolia Fomin), one botanical variety (Polystichum aculeatum var. aristatum (Christ) A. Askerov) and one new ecotype (Adiantum capillus-venerisL., “Dwarf plant – Ganja”) has been identified. The article provides information on the three-dimensional spatial areas of the sites where these plants are found, the taxonomy, morpho-biological variability and taxonomy types.
Is the Domain of Tree Dominance Needed in Simulation Models?
Authors: Rogozin M.
Published: February 2023

The methodological aspects of modeling the growth of stands in the works of A. N. Borisov and V. V. Ivanov (hereinafter the Authors) are analyzed. The indicator “area of dominance” and models of “optimal” trees with the best size ratio and proportional feeding polygons are considered. It was found out that dependent variables were used in them, which does not allow them to be used in adequate simulation models. However, the Authors still create from them a kind of abstract model of a stand with a quasi-uniform placement of trees, where there are no windows and clusters of trees, which does not happen in reality. Then the model is compared with another abstraction – static states of stands with a completeness of 1.0. Next, a table is constructed-a model of “optimal” completeness according to the conclusions of other authors, according to which, in stands of 50-120 years, it is recommended to maintain a completeness of 0.6–0.7 by thinning to increase of phytomass ofcrowns. To verify the model, the Authors use an increase in the radius of the trunk. However, such an increase does not reflect an increase in the stock over the entire area, where technological corridors appear during care cutting, which are also not taken into account in the models. As an example of a more objective approach, the works of V. A. Usoltsev and M. V. Rogozin. In the latest work, it was found that the feeding areas at the age of 30 years affect the diameter of the tree at 55 years only by 9.4±0.2%. Therefore, “areas of dominance” will lead to the creation of models beyond which 90% of the influence of other factors will remain. From the point of view of the theory of logging, the authors used dubious scientific methods, which were warned about by leading foresters back in the 1970s. The considered variants of imitation models of the growth of stands and models of care based on “areas of dominance” borrowed from zoology were, apparently, the last attempts of this kind - the era of discussion of five new laws of the development of stands and the period of changing scientific paradigms has come in forestry.
The Effect of Cultivation on the Development of Local and Introduced Varieties of Winter Wheat (Azerbaijan)
Authors: Kazimov N. , Seyidaliyev N.
Published: February 2023

Thanks to the use of agricultural techniques, in particular the use of 15-fold sprinkler irrigation, taking into account soil moisture, the use of mulching, compliance with the norms and terms of application, mineral and organic fertilizers in all varieties of winter wheat, depending on biological and morphological characteristics, the first shoots were obtained after 10-12 days after sowing. Plants reached the tillering stage in the Kirmyzygyul variety on 01/21/2020, in the Murov-2 variety on 01/26/2020, in the Aran variety on 01/25/2020, in the Maurisio variety on 01/22/2020, in the Balaton variety on 01/25/2020, Gallio variety at 01/27/2020, in Gaudio variety at 01/24/2020, the tube exit phase for the Kirmyzygyul variety at 04/02/2020, for the Murov-2 variety at 04/05/2020, for the Aran variety at 04/04/2020, at varieties Maurisio at 03/03/2020, variety Balaton at 05/04/2020, variety Gallio at 06/04/2020, variety Gaudio at 05/04/2020, heading phase for variety Kyrmyzygul at 27/04/2020, variety Murov-2 at 30.04.20, for the Aran variety at 04/29/2020, for the Maurisio variety at 04/28/2020, for the Balaton variety at 04/30/2020, for the Gallio variety at 05/01/2020, for the Gaudio variety at 04/30/2020. The growing season for the varieties Kyrmyzygul and Balaton ended 3-5 days earlier in comparison with other varieties.
Effect of Inorganic Fertilizers on the Clover Growth in Gray-Brown Soils
Authors: Khalilov S.
Published: February 2023

The presented article presents materials on the effect of mineral fertilizers on the height of clover on irrigated gray-brown soils of the Ganja-Gazakh region. Due to the biological nitrogen collected by clover in the soil, more than twice the annual rate of nitrogen is saved in one cycle, thereby supplying other agricultural fields with nitrogen. Therefore, given the role of cotton as a strategically important plant, and alfalfa as a strong feed for livestock and restoration of soil fertility, the study of the fertilizer system of both plants in the cotton-alfalfa crop rotation is one of the most urgent tasks. The application of mineral fertilizers to alfalfa plants on irrigated gray-brown (chestnut) soils had a significant impact on alfalfa growth. High altitude means high yield. During the years of research, the highest height was observed in the N60P90K60 variant on average over 3 years. Depending on the norms of mineral fertilizers, the height of alfalfa increased by 6.3-29.5 cm compared to the variant without fertilizers.
The State and Problematic Issues of Pediatrics in the Kyrgyz Republic
Authors: Baatyrova G. , Sulaimanov Sh. , Boronbaeva E. , Chernysheva E.
Published: February 2023

A review of the current system for the health and development of children and adolescents in the Kyrgyz Republic revealed a number of key issues. There is a lack of coordination among public, private, non-governmental, and international organizations for the advancement of current condition of children and adolescents. The staff of the health care system, education, social protection and other government agencies, whose activities, one way or another, are related to working with children, need to improve their skills, taking into account the expansion of policies in the field of health protection and development of children and adolescents. There is limited use of available factual data to improve the quality of medical care, habilitation and rehabilitation, disease prevention (overweight and underweight, tuberculosis, diseases of the reproductive system, psycho-emotional disorders, etc.) violence, and trauma. Environmental risks remain high (clean water, safe environment and living conditions). There is very low participation of the civil sector in decision-making and implementation of a program in the field of health care and development of children and adolescents.
Medical and Social Study of Vision Impairment in Students
Authors: Abdyrakhun kyzy M. , Bektasheva U. , Dzholdubaev S. , Kalmatov R. , Abdullaeva Zh.
Published: February 2023

Research relevance: change in vision is considered problematic, since every year the number of people, mostly students, with impaired vision is growing. In this regard, studying of students’ vision condition and assessing influencing factors seems to be an urgent task. Research objectives: study of vision impairment among students. Using the screening survey method, determine the ophthalmological status of students and identify the problems of medical care for students with visual impairments. Research materials and methods: for the study, a questionnaire was used, including questions about duration of work at the computer. In the course of work, information on the topic under study was studied and systematized. Research results: for the prevention and organization of medical and social protection system of the vision organs, it is necessary to include the control of various risk factors and negative phenomena. Conclusions: an active lifestyle and outdoor walks contribute to the prevention of diseases of the organs of vision.
Organization of Pre-hospital Care for Traumatic Injuries of Blood Vessels
Authors: Kutuev Zh.
Published: February 2023

820 case histories of victims with vascular trauma operated in the vascular department of the Osh Interregional Joint Clinical Hospital and territorial district hospitals for 2011-2020 were studied. It was found out that 96.7% of the victims did not receive any assistance before the arrival of a medical worker or their delivery to a medical institution. 650 citizens from various strata of the population and 152 urgent surgeons and traumatologists of Osh and Osh region were surveyed. It was found out that the absolute majority of the population will not master the knowledge and skills of first aid, and most importantly, they believe that the provision of first aid in case of injury should be carried out exclusively by emergency medical personnel or other medical professionals. Organizational and tactical proposals are given to improve the results of pre-hospital care for victims.
Organizational and Tactical Solutions for the Phased Treatment of Vascular Injuries
Authors: Kutuev Zh.
Published: February 2023

The case histories of 574 patients treated in the vascular department of the Osh Interregional Joint Clinical Hospital and the departments of surgery and traumatology of the Osh City Clinical Hospital for the period 2011-2020 were analyzed. The scope and nature of providing assistance to victims with vascular trauma at the place of injury, in primary and secondary health care facilities have been clarified. It was revealed that the absolute majority of victims are not provided with the full volume of first aid at the place of injury, and therefore there is a need to teach a wide segment of the population the rules of first aid. It is also indicated that it is necessary to develop a clinical protocol for providing assistance to victims with vascular trauma at all stages of the medical service.
Stone Formation Features in the Kidney of Residents in the South Region of Kyrgyzstan
Authors: Bektasheva U. , Abdyrakhun kyzy M. , Dzholdubaev S. , Кalmatov R. , Abdullaeva Zh.
Published: February 2023

Kidney stone disease (KSD), otherwise urolithiasis, is one of the most common and frequent diseases and occurs most often in patients of working age. With “urolithiasis” there is a metabolic disorder characterized by the presence of stones in the kidneys and urinary tract. Formation of kidney stones in residents of southern region in Kyrgyzstan has not been studied. Research objectives: determination of stone formation features in the kidney of patients in the southern region of Kyrgyzstan. Research materials and methods: a literary review of urolithiasis (KSD) of the kidneys and identification of stone formation features. Research results: kidney stone formation is a complex physical and chemical process, accompanied by growth, aggregation and retention of urinary stone in parts of tubular cells. Conclusions: formation of calcium oxalate and uric acid stones is associated with various metabolic processes in the body. Urinary calculi are formed as a result of a series of sequence of stages.
Digital Transformation of Brands: Issues of Interaction With Marketplaces
Authors: Simakina M.
Published: February 2023

The article examines the problems of interaction of modern companies with marketplaces in the process of brand digitalization. Entering the digital space using intermediaries has always caused significant difficulties for companies. The peculiarities of the organization and functioning of modern Russian marketplaces leave their mark on their use for the promotion and distribution of branded goods.
Gender Aspects of Labor Migration in Kyrgyzstan
Authors: Tukubasheva A. , Purdilova Z.
Published: February 2023

This article is devoted to the gender aspects of migrants in Kyrgyzstan. It describes modern types of female migration, their causes and types. The critical points in which this takes place are identified and possible transformations are analyzed.
Government and Municipal Administration in Kyrgyzstan
Authors: Arapova M. , Tultemirova G. , Sadykova R.
Published: February 2023

The main subject of public administration is the government, so it is necessary to clarify the concept of government. Research objectives: definition of government and municipal administration in Kyrgyzstan. Research materials and methods: amendments, proposals, changes and consolidation in the Kyrgyz Republic Constitution. Research results: local government operates on the basis of duties and powers separation from government bodies and the creation of e-government. Conclusions: modern information and communication technologies are used in management within the framework of state programs, and personnel are involved that combine high professional competence.
The Role of Course Activities in the Formation of the Feeling of Love for the Homeland in the Primary School
Authors: Bayramova Z. , Bayramova S. , Gamidova G.
Published: February 2023

The manifestation of a feeling of love for the Motherland and its development have been one of the issues that have attracted attention since ancient times. Civic education is at the center of the educational work of the school. The feeling of love for the Motherland is the attachment of a person to the Motherland, its land, nature, natural wealth. The article deals with the issues of patriotic education of primary school students in out-of-school institutions. It is shown that centers of children's creativity, music and sports schools, local history museums play a significant role in the cause of love for the motherland. The article talks about the experience of out-of-school institutions located in the city of Ganja of the Republic of Azerbaijan. Examples of lullabies, proverbs and sayings, bayats, songs related to the patriotic education of younger schoolchildren are given.
Some Notes on Payments Streams
Authors: Yakubova U. , Parpieva N. , Mirkhodjaeva N.
Published: February 2023

The article discusses such concepts as the payment’s streams and financial annuities, credit accounts. The generalizing characteristics of payments streams, the increased amount of constant annuity postnumerando are given. The formulas of the incremented sum are considered, as well as the current value of constant annuities postnumerando.
Geopolitical and Geoeconomic Aspects of Color Revolutions
Authors: Sadykova R. , Tultemirova G. , Arapova M.
Published: February 2023

Globalization involves the destruction of the traditional society as such due to its desire for independence, self-sufficiency and is aimed at the destruction of the mental, socio-political, financial, economic and other manifestations of the traditionalism of nation- governments. Research objectives: definition and analysis of geopolitical and geo-economic aspects of color revolutions. Research materials and methods: historical facts and events in the countries of Europe, America and Asia in which color revolutions took place in different periods. Research results: the influence of citizens and public groups within countries on the decision-making process of a national nature is weakened. Conclusions: most governments have become victims of global trends, becoming increasingly dependent on supranational, global structures.
The Role of the Russian Traveler and Zoologist M. N. Bogdanov in Studying the Nature of the Khorezm Oasis.
Authors: Tajiyeva U.
Published: February 2023

This article discusses some issues of the ecological history of the Khorezm oasis. In the work, the author tried to familiarize the reader in detail with the work of Modest Nikolaevich Bogdanov, a Russian zoologist who created his work during an expedition to Central Asia in 1873-1874. A comparative analysis of the research and findings of M. N. Bogdanov with the studies of other travelers is given. The author also tried to reveal the role of the expedition and Bogdanov's works in the further study of the flora and fauna of this region and in the creation of further works of subsequent generations in this field of science. It also provides information about the animal world, natural and climatic features, the nature of the soil and plants in the Khanate of Khiva. In the process of work, information was obtained that the traditions of caring for nature also have an ancient history, as well as the history of mankind itself. Truly, a respectful attitude to nature is priceless, rooted deeply in spirituality and culture and occupying a special place in the folk values that have been improving over the centuries.
Growing a University: A Personal History of the University of Glasgow's Crichton Campus in Dumfries
Authors: Taylor R. C.
Published: February 2023

This personal account of the University of Glasgow's Crichton Campus in Dumfries is offered as a case study to understand the recent trends towards satellite and branch campuses which form the latest phase of UK university expansion. It testifies to the enduring allure of the utopian vision and follows the struggle to survive in circumstances similar to those faced by the new campuses of the 1960s. While the details may be unique, a number of features and processes are described which may be endemic to those satellite and multi-institutional campuses which are changing the shape of higher education in the UK.
Elizabeth II, Monarchy and Union: Tradition versus Traditions
Authors: Dudley Edwards Owen
Published: February 2023

With the Death of HM Queen Elizabeth it is a useful time to reflect on the Crown and the Union in Scotland, and to question the future of both.
Analysis and Design of Production Monitoring Information Systems on Label Shoe Manufacturing Companies
Authors: Wiratama Jansen
Published: February 2023

Digital technology can be used to solve problems that arise from business activity. One company that has not optimally used digital technology is PT Tiga Tapak Mutiara, which is engaged in manufacturing shoe labels. In its business process, each related division collects data, and the data collection results will be reported to the manager to unify work activities. The production data collection process has not been carried out optimally by the relevant divisions because the conventional recording is still carried out using a spreadsheet application which can slow down the reporting process to be monitored by the leadership. As a result, a slow process can impact not completing production on time. In addition to the problem of data collection, another problem is that the completion of orders received earlier is not compared to the orders received last. The aim and contribution of this research are to integrate business processes to overcome these problems in data collection, monitoring, and order completion activities. It is necessary to design a web-based monitoring information system with the Rapid Application Development (RAD) method and the application of the First In, First Out (FIFO) method so that the ordering process can run according to the time of order. The result of this research is a web-based information system that is useful for integrating business processes to monitor and optimize production activities to be completed on time. This web-based information system has also passed the functionality test using black box testing and is following the company's needs.