bluuebunny/crossref_metadata_2025 huggingface dataset:
Cassirer and Kant on the Unity of Space and the Role of Imagination
Authors: de Sá Pereira Roberto Horácio
Published: September 2020

The focus of this paper is Cassirer’s Neo-Kantian reading of Kant’s conception of unity of space. Cassirer’s neo-Kantian reading is largely in conformity with the mainstream of intellectualist Kant-scholars, which is unsurprising, given his own intellectualist view of space and perception and his rejection of the existence of a ‘merely sensory consciousness’ as a ‘formless mass of impression’. I argue against Cassirer’s reading by relying on a Kantian distinction first recognized by Heinrich Rickert, a neo-Kantian from the Southwest school, between Kenntnis (roughly knowledge by acquaintance) and Erkenntnis (roughly propositional knowledge). Correspondingly, I claim that concepts and categories are conditions for Erkenntnis of objects as such, namely for thinking of and apprehending the pre-existing unity as an object, rather than for the ‘constitution’ of this very unity.
Platelet storage and functional integrity
Authors: Vit Gianmatteo , Klüter Harald , Wuchter Patrick
Published: September 2020

Platelet transfusion is a topic of common interest for many specialists involved in patient care, from laboratory staff to clinical physicians. Various aspects make this type of transfusion different from those of other blood components. In this review, the challenges in platelet transfusion practice that are relevant for laboratory colleagues will be discussed, highlighting how the biochemical and structural characteristics of these blood elements directly affect their function and consequently the clinical outcome. More than 1,300 platelet concentrates are transfused in Germany every day, and several types are offered by their respective manufacturers. We describe the technological advances in platelet concentrate production, with a focus on how the storage conditions of platelets can be improved. Laboratory quality assessment procedures for a safe transfusion are discussed in detail. For this purpose, we will refer to the Hemotherapy Directives (Richtlinie Hämotherapie) of the German Medical Association.
Arrangement structure of carbon nanofiber with excellent spectral radiation characteristics
Authors: Yin Jinying , Han Jiangyue , Qi Caihui , Wang Yan
Published: September 2020

To explore the spectral radiation characteristics of carbon nanofibers, a finite-difference time-domain method has been applied to study and calculate the scattering/absorption factors of carbon nanofibers with various arrangements, while the filler contents are 61.15%, 53.81%, 48.92%, 44.03% and 39.13% in the spectrum band of 2.5–15 µm. The effects of the nanofiber content, 2D/3D random arrangement and nanofiber radius on scattering/absorption characteristics have been analyzed. The analytical results show that the spectral radiation characteristics of carbon nanofibers have been significantly increased with an increase in the filler content. When the nanofiber content reduced to 48.92%, the random arrangement structure of carbon nanofiber plays an essential role in determining the spectral radiation characteristics. Analytical results prove that the prediction accuracy has been significantly improved by 30.12% by sing the 3D random arrangement model than by using the 2D uniform arrangement model. This study proposed a 3D model to predict the spectral radiation characteristics of carbon nanofibers and their aggregates in engineering nanocomposites.
A highly sensitive biosensor based on methacrylated graphene oxide-grafted polyaniline for ascorbic acid determination
Authors: Naghib Seyed Morteza , Behzad Farahnaz , Rahmanian Mehdi , Zare Yasser , Rhee Kyong Yop
Published: September 2020

Functionalized graphene-based nanocomposites have opened new windows to address some challenges for increasing the sensitivity, accuracy and functionality of biosensors. Polyaniline (PANI) is one of the most potentially promising and technologically important conducting polymers, which brings together the electrical features of metals with intriguing properties of plastics including facile processing and controllable chemical and physical properties. PANI/graphene nanocomposites have attracted intense interest in various fields due to unique physicochemical properties including high conductivity, facile preparation and intriguing redox behavior. In this article, a functionalized graphene-grafted nanostructured PANI nanocomposite was applied for determining the ascorbic acid (AA) level. A significant current response was observed after treating the electrode surface with methacrylated graphene oxide (MeGO)/PANI nanocomposite. The amperometric responses showed a robust linear range of 8–5,000 µM and detection limit of 2 µM (N = 5). Excellent sensor selectivity was demonstrated in the presence of electroactive components interfering species, commonly found in real serum samples. This sensor is a promising candidate for rapid and selective determination of AA.
The Problem of Reality and Modal Ontology
Authors: Šerpytytė Rita
Published: September 2020

The problem of the relation and difference between things and objects is one of the most decisive issues for the conception of the real. These words are usually used interchangeably – and not only in their everyday usage. There are some contemporary philosophical positions that consider almost “everything” as an object; on the other hand, there are proponents of a strict separation of objects and things. How did it happen that the concept of thing (res) and object (obiectum) not only began to theoretically “compete” with each other but also sometimes came to represent differently conceived realities, and even occasionally came to represent an identical conception of reality? This article, on the one hand, discusses the philosophical strategies that reveal the difference between objects and things and enable such a conception of reality which takes into account the Kantian distinction between Realität and Wirklichkeit. On the other, it reconstructs Giorgio Agamben’s project of modal ontology. Agamben’s take on the question What is real? is oriented toward the modus of being and could be traced back to the recognition of the difference between objects and things as well as the “restoration of the life of things themselves.”
A retrospective on MXene-based composites for solar fuel production
Authors: Zhu Yisong , Wu Zhenjun , Xie Xiuqiang , Zhang Nan
Published: September 2020

MXene with two-dimensional layered structure and desirable electronic properties has emerged as a promising candidate to construct MXene-based composites towards various photocatalytic applications. As compared to the downhill-type photodegradation reactions, artificial photosynthesis often involves thermodynamic uphill reactions with a large positive change in Gibbs free energy. Recent years have witnessed the effectiveness of MXene in enhancing the photoactivity of MXene-based composites for solar fuel synthesis. In this review, we mainly focus on the applications of MXene-based composites for photocatalytic solar fuel production. We will start from summarizing the general synthesis of MXene-based composite photocatalysts. Then the recent progress on MXene-based composite photocatalysts for solar fuel synthesis, including water splitting for H2 production, CO2 reduction to solar fuels, and N2 fixation for NH3 synthesis is elucidated. The roles of MXene playing in improving the photoactivity of MXene-based composites in these applications have also been discussed. In the last section, perspectives on the future research directions of MXene-based composites towards the applications of artificial photosynthesis are presented.
To separate or not to separate: what is necessary and enough for a green and sustainable extraction of bioactive compounds from Brazilian citrus waste
Authors: Zuin Vânia G. , Ramin Luize Z. , Segatto Mateus L. , Stahl Aylon M. , Zanotti Karine , Forim Moacir R. , da Silva Maria Fatima das Graças F. , Fernandes João Batista
Published: September 2020

Increasing demands to obtain chemicals via greener and more sustainable materials and processes introduces concepts that should be considered and applied from lab to larger scales. Obtaining bioactive chemicals from agro-industrial non-food biomass waste can combine benign techniques and bio-circular economy to reach this goal. After extraction, evaluating profitability and environmental impacts to decide whether separation – and to what extent – is necessary or not is indispensable. This could be integrated into an approach known as sufficiency, as an important criterion for sustainability. From this perspective, Brazil’s annual generation of 8 million tons of orange waste is relevant, since citrus waste has large amounts of high-value compounds, such as pectin, d-limonene and flavonoids. This case study aimed at developing and comparing green and sustainable analytical methods to obtain flavonoids from orange peel. Homogenizer, ultrasound and microwave-assisted extractions were employed using chemometric tools, considering time, sample/solvent ratio, temperature and ethanol concentration as variables to obtain extracts containing hesperidin, naringenin, hesperetin and nobiletin. The bioactive flavonoids were determined by high-performance liquid chromatography (HPLC-UV). Microwave extraction was the most efficient method for obtaining the majority of flavonoids studied, six times more for hesperidin. Moreover, orange waste from different farming models showed diverse chemical profiles showing the importance of this alternative in natural product resources.
Experimental set up for magnetomechanical measurements with a closed flux path sample
Authors: El Youssef Mohamad , Van Gorp Adrien , Clenet Stéphane , Benabou Abdelkader , Faverolle Pierre , Mipo Jean-Claude
Published: September 2020

In this article, an experimental procedure is presented to handle magnetic measurements under uniaxial tensile stress reaching the plastic domain. The main advantage of the proposed procedure is that it does not require an additional magnetic core to close the magnetic flux path through the studied sample. The flux flows only in the sample, and no parasitic air gaps are introduced, thus avoiding the use of the H-coil to evaluate the magnetic field, which is often very sensitive and not easy to calibrate. A specimen of nonoriented FeSi (1.3%) sheet (M330-35A) is characterized under uniaxial tensile stress. To validate the proposed procedure, a comparison with the single sheet tester procedure is carried out. The results obtained by the two procedures are in good agreement. Moreover, to illustrate the possibilities offered by the proposed procedure, we confirm some results obtained in the literature. We show that the positive plastic strain leads to a significant degradation of magnetic behavior. An applied tensile stress on a virgin (unstrained) sample leads to a degradation of the magnetic behavior. However, on a pre-strained sample, an applied tensile stress results in reducing the deterioration caused by the plastic strain until a stress value called optimum is attained. Above this threshold, the magnetic behavior re-deteriorates progressively.
Kommunalbüro für ärztliche Versorgung in Bayern als Instrument zur Planung und Steuerung in der Versorgung
Authors: Geuter Gunnar , Ewert Thomas , Wildner Manfred
Published: September 2020

Gesellschaftliche und demographische Entwicklungen, Veränderungen im Krankheitsspektrum sowie medizinisch-technischer Fortschritt erfordern neue nutzerorientierte und bedarfsgerechte Konzepte der Gesundheitsversorgung und ein Zusammenwirken unterschiedlicher Akteure über den Gesundheitssektor hinaus. Kommunen kommt hierbei eine besondere Rolle zu. Das Kommunalbüro für ärztliche Versorgung im Bayerischen Landesamt für Gesundheit und Lebensmittelsicherheit unterstützt sie dabei.
Good Stewardship: Im Dienst an mehr Gesundheit für alle
Authors: Wildner Manfred
Published: September 2020

Gute Stewardship ist mehr als eine Vision: Es ist im 21. Jahrhundert eine Notwendigkeit. Menschliche Gemeinschaft verlangt in einer planetaren Perspektive nachhaltiges Wirtschaften, verantwortungsvolle Planungen und Solidarität im Umgang mit begrenzten natürlichen wie humanen Ressourcen. Diese Notwendigkeit stellt einerseits einen erhöhten Anspruch an das Gesundheitswesen, andererseits setzt sie Nachhaltigkeit und Gesundheit in allen Politikfeldern auf die Agenda – COVID-19 illustriert dies.
A Welfare Assessment of Revenue Management Systems
Authors: Dupuis Nicolas , Ivaldi Marc , Pouyet Jerome
Published: September 2020

We study the welfare impact of revenue management, a practice which is widely spread in the transport industry, but whose impact on consumer surplus remains unclear. We develop a theoretical model of revenue management allowing for heterogeneity in product characteristics, capacity constraints, consumer preferences, and probabilities of arrival. We also introduce dynamic competition between revenue managers. We solve this model computationally and recover the optimal pricing strategies. We find that revenue management is generally welfare enhancing as it raises the number of sales.
Large deviations and Berry–Esseen inequalities for estimators in nonhomogeneous diffusion driven by fractional Brownian motion
Authors: Tanoh Kouacou , N’zi Modeste , Yodé Armel Fabrice
Published: September 2020

We are interested in bounds on the large deviations probability and Berry–Esseen type inequalities for maximum likelihood estimator and Bayes estimator of the parameter appearing linearly in the drift of nonhomogeneous stochastic differential equation driven by fractional Brownian motion.
Die klassische Tradition in der russischen Literatur: zum Problem ihrer Genesis
Authors: Bucharkin Petr E.
Published: September 2020

The article considers the poetry of S. S. Averintsev. The analysis of its dominating thematic, generic and verse features allows us to see in this poetry a peculiar development of literary trends of the late 17th/early 18th centuries, which were connected with the transformation of autochthonous artistic sources and generated a whole range of original texts, including poetic ones (“Povest’ o Gore-Zlochastii”, Songs of P. Kvashnin-Samarin). On the basis of another historic correlation Averintsev’s poetry can be considered an attempt to present the classical tradition of Russian literature as a direct development of medieval verbal principles in their Moscow variant. This position was supported by the scholar’s philological conceptions and was also confirmed by the statements of a number of literary critics, as well as by the poetic practice of Olga Sedakova, which was close to that of Averintsev. The article explores the correlation of these perceptions with historical and literary facts.
Teodor Trajanov als Vermittler zwischen der Wiener und der bulgarischen Moderne
Authors: Vlashki Mladen
Published: September 2020

The study is looking into the first creative period of the Bulgarian poet Teodor Trajanov based on his newly rediscovered works. They allow the description of the author as a conscious mediator between the Viennese and the Bulgarian modernity, who imports himself in the vernacular Bulgarian literary environment as a “modern poet” from Vienna. For the first time, the analysis discovers actual connections between the poetry of Trajanov and the specifics of the Viennese modernity as a cultural environment. On the basis of critical texts from the author, his views on modern works are described and defined in the spirit of the age as “decadent”. Trajanov is also the only Bulgarian literary figure, who fits the processes of the late Viennese modernism with his screenplay for a play in the Viennese Volksoper from 1914. The text considered lost by Trajanov researchers has been presented for the first time after its discovery by the author of the article, with the required contextual reconstruction. Here, the mediatory role of the poet between two modern European cultures of the beginning of the 20th century, as well as new perspectives not only for the exploration of Trajanov’s poetry but also for reconsidering the inception of the Bulgarian modernism, are considered.
Wahrgenommene Veränderungen in der Spiritual Care-Kompetenz nach einem Online Spiritual Care-Seminar bei Studierenden in Gesundheitsfächern
Authors: Magin Susanne , Frick Eckhard , Maier Kathrin
Published: September 2020

Hintergrund:Forschung zeigt, dass der Einsatz von Spiritual Care nicht nur durch Zeit- und Ressourcenknappheit erschwert wird, sondern auch durch einen Mangel an Aus- und Weiterbildung sowie durch das bei Gesundheitsfachpersonen vorherrschende Gefühl von Inkompetenz in diesem Bereich. Im deutschen Sprachraum existiert wenig Forschung zu Kurs- oder Trainingsangeboten in Spiritual Care und deren Auswirkung auf die Kompetenzwahrnehmung von zukünftig im Gesundheitswesen Tätigen.Methode: 12 leitfadengestützte Interviews mit bayerischen Studierenden verschiedener Gesundheitsfächer, die an einem virtuellen Spiritual Care-Seminar teilgenommen haben, wurden mit qualitativer Inhaltsanalyse ausgewertet.Ergebnisse: Mithilfe des Seminars konnten verschiedene Arten der Veränderung angestoßen werden: (1) Öffnung: Vom Engen zur Weitung, (2) Präzisierung: Von Abstraktem zu Konkretem‚ (3) Fokussierung: Von Indifferentem zur Bewusstheit‚ (4) Ausweitung: Vom Exemplarischen zur Gesamtheit, (5) Professionalisierung: Von Privatem zu Beruflichem, (6) Persönlichkeitsentwicklung: Vom Zaghaften zur Kompetenz. Zudem brachte das Material die Kategorie (7) Fortbestand: Unverändertes und Leerstellen hervor.Diskussion: Die Ergebnisse weisen darauf hin, dass ein freiwilliges Online Spiritual Care-Seminar einen Transformationsprozess bei den teilnehmenden Studierenden auslösen konnte. Sie öffnen den Raum, die zugrundeliegenden Mechanismen weiter zu erforschen. Dies soll Lehrende ermutigen, Spiritual Care ins Studium zu integrieren, und dadurch sowohl das Kompetenzgefühl für als auch die Anwendungswahrscheinlichkeit von Spiritual Care in der Zukunft erhöhen.
Falsifiable Hypotheses, Alternate Hypotheses and the Methodological Conundrum of Biblical Exegesis
Authors: Edenburg Cynthia
Published: September 2020

It has become fashionable to bemoan the state of diachronic biblical criticism since the application of its method involves subjective judgments. Should diachronic criticism be laid to rest? This programmatic essay engages Popper’s view of scientific propositions as falsifiable hypotheses, and reevaluates the importance of alternate hypotheses. The discussion considers the way the different purposes of scholars inform their practice of method and their evaluation of opposing explanations. The methodological observations are illustrated with examples from the Covenant Code and Deut 1–12.
What verb-final and V2 have in common: evidence from the prosody of German restrictive relative clauses in adults and children
Authors: Sanfelici Emanuela , Féry Caroline , Schulz Petra
Published: September 2020

Theoretical accounts agree that German restrictive relative clauses (RCs) are integrated at the level of syntax as well as at the level of prosody (Brandt1990; Gärtner1998, 2002; Endriss and Gärtner2005; Catasso and Hinterhölzl2016; Sanfelici et al.2017) in both the default verb-final and the marked verb-second variant (referred to as iV2). Both variants are assumed to show the same prosodic pattern, i. e., prosodic integration into the main clause, and not unintegrated prosody, which would signal a sequence of two main clauses. To date strong empirical evidence for this close correspondence between prosody and syntax in RCs is missing. Findings regarding prosodic integration of verb-final RCs are not consistent, and research regarding the prosody of iV2 structures is very scarce. Using a delayed sentence-repetition task, our study investigated whether subordination is signaled by prosody in RCs in both the verb-final and the V2 variant in adults (n=21n=21). In addition, we asked whether young language learners (n=23n=23), who at the age of 3 have just started to produce embedded clauses, are already sensitive to this mapping. The adult responses showed significantly more patterns of prosodic integration than of prosodic non-integration in the V-final and the iV2 structures, with no difference between the two conditions. Notably, the child responses mirrored this adult behavior, showing significantly more patterns of prosodic integration than of prosodic non-integration in both V-final and iV2 structures. The findings regarding adults’ prosodic realizations provide novel empirical evidence for the claim that iV2 structures, just like verb-final RCs, show prosodic integration. Moreover, our study strongly suggests that subordination is signaled by prosody already by age 3 in both verb-final and V2 variants of RCs.
Kenji Tsuda: Liberal Protestantism and Christian Studies at Kyoto University: A Case Study of Tetsutaro Ariga
Authors: Tsuda Kenji
Published: September 2020

Ariga Tetsutaro (1899–1977) war Professor für das Studium des Christentums an der Universität Kyoto und gehörte dort der zweiten Professoren-generation an. Er legte die Grundlagen der Patristik und der Erforschung des Christentums in Japan. In seinem Hauptwerk “Origenes” hatte er den Historismus in der Theologie erforscht, aber nachdem er seinen Dienst als Professor an der staatlichen Universität aufgenommen hatte, die die Trennung von Staat und Religion hochhielt, suchte er nach Wegen, ein ‘Studium des Christlichen’ zu etablieren, das sich von der Theologie unterschied. Dabei dienten ihm Schleiermachers “Kurze Darstellung des theologischen Studiums” und die Tradition des deutschen liberalen Protestantismus als Anhaltspunkte. Anstatt der Theologie, die den Glauben als methodischen Ausgangspunkt hat, und der Religionswissenschaft, die nur die distanzierte Objektivität als Ausgangspunkt wählt, schlug er als neuen Versuch ein Christliches Studium mit akademischem Standpunkt vor, bei dem der Gelehrte eine Forschungshaltung einnimmt, die durch ein Mindestmaß an vernünftiger Kritik und ‘Ur-Sympathie’ gegenüber der Religion geprägt ist.
Eiichi Katayanagi: Liberal Protestantism and Christian Studies at Kyoto University: A Case Study of Kazuo Muto
Authors: Katayanagi Eiichi
Published: September 2020

KazuoMuto (1913–1995) war Professor für das Studium des Christentums an der Universität Kyoto und gehörte der dritten Professorengeneration an. Er war sich der Stellung der Dialektischen Theologie voll bewusst, und davon ausgehend verfolgte er neue Möglichkeiten der Religionsphilosophie, wobei sich seine Forschungen an der subjektiven Innerlichkeit und der Moral im liberalen Protestantismus orientierte. Die Wahrheitsforschung als Wissenschaft verlange natürlich eine kritische Neutralität, aber sie muüsse auch religiöse Wahrheiten im Blickfeld haben, die sich nicht durch bloßes Zuschauen offenbaren, sondern erst dadurch, dass man sich für sie engagiert. Kazuo analysierte die Argumente von Troeltsch, Barth und Tillich. Dabei stimmte er Tillichs ‘Korrelation zwischen der existentiellen Frage und der theologischen Antwort’ zu. Dennoch dachte er, dass die Ernsthaftigkeit des die existentielle Frage Stellenden der Theologie immanent sein müsse, und entwickelte dabei nicht nur eine ‘antwortende Theologie’, sondern auch eine ‘fragende Theologie’. Diese Haltung hatte er vor allem von Kierkegaard gelernt, so erklärte er, Frage und Antwort seien nicht voneinander getrennt, sondern müssten miteinander zusammenhängen.
La variación formal de los cuantificadores en catalán: estudio diacrónico (siglos XV‒XX)
Authors: Ramos Joan-Rafael
Published: September 2020

This article studies the formal variation of the existential quantifiers u/un (‘one; a, an’), algú/algun (‘someone; some’), ningú/ningun (‘no one, anyone; any’) and the distributive universal quantifier cada u/cada un (‘everyone’) in Catalan. The research is based on an extensive diachronic corpus of texts written between the 15th and 20th centuries. The author classifies the syntactic structures of these quantifiers and analyses their meaning and formal vacillations: apocopated form (without ‑n) vs. non-apocopated form (with ‑n). Although hesitations tend to disappear gradually during the period under analysis, the uses of these quantifiers change in Catalan dialects. In fact, distinct geographical areas adopt different distributions of form and function. These linguistic changes are explained, highlighting the mutual influences and interactions between phono-syntactic, phonological, analogical and pragmatic factors.
Die Macht der Bilder und Bilder der Macht: die sprachliche Konstruktion von Nationalismus und Konservatismus in der strategischen politischen Kommunikation von Vox España
Authors: Issel-Dombert Sandra
Published: September 2020

From a theoretical and empirical linguistic point of view, this paper emphasizes the importance of the relationship between populism and the media. The aim of this article is to explore the language use of the Spanish right wing populism party Vox on the basis of its multimodal postings on the social network Instagram. For the analysis of their Instagram account, a suitable multimodal discourse analysis (MDA) provides a variety of methods and allows a theoretical integration into constructivism. A hashtag-analysis reveals that Vox’s ideology consists of a nativist and ethnocentric nationalism on the one hand and conservatism on the other. With a topos analysis, the linguistic realisations of these core elements are illustrated with two case studies.
The GTPase Arl8B Plays a Principle Role in the Positioning of Interstitial Axon Branches by Spatially Controlling Autophagosome and Lysosome Location
Authors: Adnan Gee , Rubikaite Aine , Khan Moqadisa , Reber Michael , Suetterlin Philip , Hindges Robert , Drescher Uwe
Published: September 2020

Interstitial axon branching is an essential step during the establishment of neuronal connectivity. However, the exact mechanisms on how the number and position of branches are determined are still not fully understood. Here, we investigated the role of Arl8B, an adaptor molecule between lysosomes and kinesins. In chick retinal ganglion cells (RGCs), downregulation of Arl8B reduces axon branch density and shifts their location more proximally, while Arl8B overexpression leads to increased density and more distal positions of branches. These alterations correlate with changes in the location and density of lysosomes and autophagosomes along the axon shaft. Diminishing autophagy directly by knock-down of atg7, a key autophagy gene, reduces branch density, while induction of autophagy by rapamycin increases axon branching, indicating that autophagy plays a prominent role in axon branch formation.In vivo, local inactivation of autophagy in the retina using a mouse conditional knock-out approach disturbs retino-collicular map formation which is dependent on the formation of interstitial axon branches. These data suggest that Arl8B plays a principal role in the positioning of axon branches by spatially controlling autophagy, thus directly controlling formation of neural connectivity in the brain.

SIGNIFICANCE STATEMENTThe formation of interstitial axonal branches plays a prominent role in numerous places of the developing brain during neural circuit establishment. We show here that the GTPase Arl8B controls density and location of interstitial axon branches, and at the same time controls also density and location of the autophagy machinery. Upregulation or downregulation of autophagyin vitropromotes or inhibits axon branching. Local disruption of autophagyin vivodisturbs retino-collicular mapping. Our data suggest that Arl8B controls axon branching by controlling locally autophagy. This work is one of the first reports showing a role of autophagy during early neural circuit development and suggests that autophagy in general plays a much more prominent role during brain development than previously anticipated.
Role of the periodic table in discovery of new elements
Authors: Hoffman D.C.
Published: September 2020

This year (2009) marks the 140th Anniversary of Mendeleev's original 1869 periodic table of the elements based on atomic weights. It also marks the 175th anniversary of his birth in Tolbosk, Siberia. The history of the development of periodic tables of the chemical elements is briefly reviewed beginning with the presentation by Dmitri Mendeleev and his associate Nikolai Menshutkin of their original 1869 table based on atomic weights. The value, as well as the sometimes negative effects, of periodic tables in guiding the discovery of new elements based on their predicted chemical properties is assessed. It is noteworthy that the element with Z=101 (mendelevium) was identified in 1955 using chemical techniques. The discoverers proposed the name mendelevium to honor the predictive power of the Mendeleev Periodic Table. Mendelevium still remains the heaviest element to have been identified first by chemical rather than nuclear or physical techniques. The question concerning whether there will be a future role for the current form of the periodic table in predicting chemical properties and aid in the identification of elements beyond those currently known is considered.
Automation of column-based radiochemical separations: a comparison of fluidic, robotic, and hybrid architectures
Authors: Grate J. W. , O'Hara M. J. , Farawila A. F. , Ozanich R. M. , Owsley S. L.
Published: September 2020

Two automated systems have been developed to perform column-based radiochemical separation procedures. These new systems are compared with past fluidic column separation architectures, with emphasis on using disposable components so that no sample contacts any surface that any other sample has contacted, and setting up samples and columns in parallel for subsequent automated processing. In the first new approach, a general purpose liquid handling robot has been modified and programmed to perform anion exchange separations using 2 mL bed columns in 6 mL plastic disposable column bodies. In the second new approach, a fluidic system has been developed to deliver clean reagents through disposable manual valves to six disposable columns, with a mechanized fraction collector that positions one of four rows of six vials below the columns. The samples are delivered to each column via a manual 3-port disposable valve from disposable syringes. This second approach, a hybrid of fluidic and mechanized components, is a simpler more efficient approach for performing anion exchange procedures for the recovery and purification of plutonium from samples. The automation architectures described can also be adapted to column-based extraction chromatography separations.
A comparison of 5-year administration of cyproterone acetate or leuprolide acetate in combination with estradiol in transwomen
Authors: Gava Giulia , Mancini Ilaria , Alvisi Stefania , Seracchioli Renato , Meriggiola Maria Cristina
Published: September 2020

Objective

The impact of different combinations of long-term gender-affirming hormone therapy (GAHT) in transwomen (TW) is largely unknown. To assess the effects of 5-year administration of cyproterone acetate (CPA) or leuprolide acetate (Leu) plus transdermal or oral estradiol (E).

Design

Cohort study based on prospectively collected data. Fifty TW received 50 mg CPA daily orally (n = 25; CPA+E group) or 3.75 mg Leu i.m. monthly (n = 25; Leu+E group) with 1 or 2 mg E daily for 5 years. Reproductive hormones, biochemical and anthropometric parameters, body composition and bone mineral density (BMD) were assessed.

Results

LH, FSH and total testosterone levels were similarly and significantly suppressed in both groups. Prolactin increased only in the CPA+E group (P = 0.002). Fasting insulin resistance and glucose progressively increased in the CPA+E group only (treatment × time effect P = 0.002 and P = 0.043, respectively). Total cholesterol increased more in the Leu+E group than in the CPA+E group and HDL-cholesterol decreased in the CPA+E group (time × treatment interaction effect, P = 0.007). Lumbar and total body BMD increased in both groups after 3 years. No serious adverse events were recorded.

Conclusions

Both regimens were effective in suppression of T production. CPA+E worsened the metabolic profile with a slight increase in PRL levels. All subjects presented an increase in BMD regardless of treatment. These preliminary data could have clinical implications in the choice of GAHT, in particular for those TW not requiring gender-affirming surgery.
Evaluation of an individualized education program in pituitary diseases: a pilot study
Authors: Albarel F , Pellegrini I , Rahabi H , Baccou C , Gonin L , Rochette C , Vermalle M , Cuny T , Castinetti F , Brue T
Published: September 2020

Introduction

The low prevalence of pituitary diseases makes patient autonomy crucial, and self-management programs should be more common.

Objectives

To assess the efficacy of an education program for patients with pituitary diseases in terms of patients’ quality of life, satisfaction and goal attainment.

Design and methods

Adult patients with pituitary disorders were recruited in a tertiary referral center and chose at least three of eight possible sessions on various topics, from disease management to psychosocial issues. Patients were included if they attended at least three sessions between 2012 and 2016 and completed the initial, final, and follow-up questionnaires. Data on quality of life (SF36), satisfaction and goal attainment were analyzed.

Results

Fifty-three patients were included (33 women; mean age, 53.5 years). There were a significant quality of life improvements in terms of physical and psychic limitation scores at the final assessment that persisted at follow-up evaluation. Most patients reached their objectives, especially those on sharing experiences and improving autonomy and self-confidence. More than half set new objectives at the end of the program, the most popular one being to reinforce their knowledge of their pituitary disease, its evolution and treatment (17.1% of patients). The mean overall satisfaction score was 3.75/4. At follow-up evaluation, patients reported improved self-management of pituitary disease (3.6/5) and improved self-efficacy (3.8/5).

Conclusion

Individualizing the educational objectives of patients with pituitary disease improves the way they live with their disease. If confirmed in other cohorts, this approach could become the gold standard for education programs in rare endocrine diseases.
Estimación de parámetros genéticos de Gmelina arborea Roxb. (melina) en el Caribe de Costa Rica
Authors: Hernández-Castro William , Badilla Valverde Yorleny , Murillo-Gamboa Olman
Published: September 2020

La Gmelina arborea es una de las especies de mayor importancia en proyectos de reforestación comercial en Costa Rica y actualmente, forma parte importante del programa de mejoramiento genético en Costa Rica liderado por GENFORES. El objetivo del presente estudio consistió en determinar los parámetros genéticos de 54 clones de melina utilizados en un ensayo clonal en la región Caribe de Costa Rica. El ensayo se estableció con un diseño de bloques completos al azar con cuatro repeticiones por tratamiento, con un distanciamiento de 4 m x 3 m. Se calcularon parámetros genéticos a los 10, 22 y 34 meses, para las variables diámetro a la altura del pecho (DAP), altura comercial, volumen comercial y calidad del fuste, utilizando el software SELEGEN, el cual se basa en el método REML/BLUP, además, se realizaron correlaciones genéticas entre las variables evaluadas. Los resultados muestran mayor heredabilidad individual en sentido amplio para las variables de volumen comercial y DAP, además, reflejan que la calidad del fuste a los 22 y 34 meses presenta los mayores coeficientes de heredabilidad individual y heredabilidad media del clon. Las correlaciones genéticas reflejan valores altos y positivos entre las variables DAP-volumen comercial y altura comercial-calidad del fuste, a los 34 meses de edad, con un 0.97 y 0.74, respectivamente. Los clones 17 y 34, mostraron ser los mejores en el ranking genético en términos de volumen comercial; el material de control y el clon 19, fueron los que se ubicaron en las últimas posiciones del ranking. Se obtuvo una ganancia genética a los 34 meses de edad de 6.11 % y 9.36 % en DAP y volumen comercial, respectivamente. Se concluye que existe variabilidad genética en los materiales genéticos utilizados, que permiten obtener ganancias genéticas importantes, sobre todo si se utilizan los primeros 10 clones del ranking genético de las accesiones evaluadas.
Evaluación del impacto ambiental en una industria gráfica, que utiliza impresión litográfica tipo “offset”
Authors: Villalobos-González Wendy , Sibaja-Brenes José Pablo , Mora-Barrantes José Carlos , Álvarez-Garay Benjamín
Published: September 2020

La industria gráfica se dedica a la impresión de documentos, que utilizan diferentes tecnologías, una de estas es la impresión litográfica tipo “offset”. El proceso productivo de este tipo de industria, así como el uso de sustancias químicas, generan impactos ambientales que pueden afectar de forma negativa al ambiente. Una evaluación de impacto ambiental (EIA), tiene la finalidad de identificar y evaluar los impactos ambientales y generar medidas preventivas, correctivas y compensatorias, en pro del ambiente. Entre los principales impactos teóricos de este tipo de industria están: generación de aguas residuales, emisión de gases, generación de ruido y residuos sólidos. En el presente proyecto de investigación se realizó una identificación, valorización y priorización de los principales aspectos ambientales (AAs) e impactos ambientales (IAs) generados en una industria litográfica tipo “offset” en Costa Rica. Con el objetivo de conocer la situación ambiental de la industria, se realizaron análisis fisicoquímicos de aguas residuales (AR), compuestos orgánicos volátiles (VOCs), partículas totales en suspensión (PTS), ruido y luminosidad. La identificación de los AAs se efectuó en conjunto con los funcionarios de la empresa, con expertos en gestión ambiental y mediante sesiones de trabajo con grupos focales, mediante herramientas como: revisión bibliográfica, lista de chequeo, entrevistas e inspecciones de campo. La valorización y priorización de los AAs identificados se llevó a cabo mediante la metodología denominada Matriz de Importancia de Impacto Ambiental (MIIA). En total se identificaron 16 AAs y 5 IAs. El AA crítico más negativo para el ambiente es la emisión de VOCs, lo cual se debe principalmente a las altas concentraciones encontradas en el ambiente interno de la planta de producción y a la ineficiencia de los sistemas de extracción general o localizada. Los tres principales IAs de carácter negativo al ambiente encontrados fueron: contaminación de la atmósfera, afectación a la salud y agotamiento de recursos no renovables, con valores de impacto ambiental de -64, -62 y -62, respectivamente.
La eficacia pedagógica en la cultura organizativa escolar y la comunidad profesional de aprendizaje
Authors: Mendoza Velazco Derling José , Cejas Martínez Magda Francisca , Navarro Cejas Mercedes , Flores Hinostroza Elizeth Mayrene , Castillo Pinos Karina Maribel
Published: September 2020

El objetivo del presente estudio fue analizar la eficacia docente en la cultura organizativa de las escuelas y la comunidad profesional de aprendizaje. La investigación fue de carácter cuantitativo, con una muestra constituida por muestreo aleatorio simple de 359 profesores que trabajaban en escuelas de nivel inicial, básico y general unificado de las ciudades de Cuenca y Azogues, Ecuador. Se aplicó como instrumentos cuatro cuestionarios tipo Likert de cinco opciones de respuesta, con el método de análisis de prueba t, F y Sheffe. Mediante el análisis de correlación y regresión múltiple, los resultados indicaron que los maestros responden a la organización de la escuela, según sus características personales. La cultura organizativa de la escuela se está transformando gradualmente, en una cultura positiva e ideal. La comunidad profesional de aprendizaje tuvo un efecto positivo en la eficacia de los maestros. Como conclusión, la cultura organizativa de la escuela y la comunidad profesional de aprendizaje debe ir más allá de la dimensión interactiva y pasar a la dimensión de la integración como elementos de la mejora de la escuela para obtener una mayor eficacia pedagógica.
Smart technology of public administration as a driving force of its development
Authors: Bobrovskyi Oleksii
Published: September 2020

It is stated that the systemic transformational changes taking place in Ukraine require the use of effective methods, technologies and information-technological and organizational means of management. This can be facilitated by the technologization of power activities through modern information and analytical tools and technologies to ensure the quality and speed of decisions. The means of smart technologies and their features are considered. It is proved that the creation of smart technology platforms will promote the development of public administration in local communities, the practical effectiveness and efficiency of the impact on managed systems.
Directions for the protection of society and the individual in the fight against cybercrime
Authors: Voronkova Valentyna
Published: September 2020

The relevance of the research topic is that with the development of computer power in the digital age, the potential of mankind grows, the capabilities of machines expand, new and influential platforms appear, which involve criminals from the criminal cyber underground trying to use tomorrow's technologies. , so the impending hurricane of impending technological danger can no longer be ignored. The purpose of the article is to conceptualize the protection of society and the individual in the fight against cybercrime, to develop ways and measures to ensure society against the crimes of the future and the legal regulation of global cybersecurity.
Problems of implementation of elements of distance education during quarantine aimed at preventing the spread of COVID-19
Authors: Karamyshev Dmytro , Ivanova Irina , Orlov Oleksandr
Published: September 2020

The events surrounding the pandemic have forced us to redefine the importance of distance education (DEC) both in the globalized world and in Ukraine in particular. The speed of the unfolding events did not leave an opportunity to prepare in advance for the new educational conditions. Moreover, many had the impression that a week or two of forced vacation will pass quickly and everything will return to normal. But everything turned out much worse than anyone could have predicted.Therefore, there was an urgent need to restructure the entire educational process in a short time, to transfer it to a remote mode, relying only on available, albeit limited, strength and resources.The purpose of the article is to summarize the experience of HarRI NAPA under the President of Ukraine in the implementation of distance learning during quarantine activities.
Scientometric methods of analysis of the effectiveness of scientific research according to Web of Sciense
Authors: Kvitka Sergiy , Starushenko Halyna , Andrianov Ihor
Published: September 2020

The purpose of the study is to determine the factors for increasing the representation of the Ukrainian scientific community in the international scientific community and raising the international scientific authority of Ukraine.Used Results of the annual G20 evaluation - the effectiveness of research in 2019, conducted by the Institute of Scientific Information (ISI), part of the Web of Science Group.The principles of introduction of scientometric methods of research of publishing activity of scientists in the international and Ukrainian scientific space are considered. Based on the processing of statistical material and the obtained quantitative estimates, a comparative analysis of the effectiveness of research in the G20 and Ukraine according to the Web of Science. In this area, some differences between Ukraine and countries that are world leaders in the organization of the research process are shown. Recommendations for increasing the representation of the Ukrainian scientific community on the Web of Science platform and raising the international scientific authority of Ukraine are offered.
Public procurement system as an effective tool e-government to combat corruption in Ukraine in the context of e-democracy
Authors: Rozhak Lesia
Published: September 2020

The paper presents the results of a study on the implementation of the public procurement system as an effective tool of e-government aimed at preventing corruption offenses. The key characteristics and features of the ProZorro electronic procurement system, as well as its impact on the level of e-government development in Ukraine are identified. At the same time, recommendations are given on priority measures to increase the objectivity and transparency of public procurement processes and the development of e-democracy in Ukraine.
Digital transformation as a factor in improving the efficiency of public administration by results: the experience of the United Kingdom
Authors: Sydorenko Oleh
Published: September 2020

The report identifies the benefits of using information and communication technologies in public administration. The essential content of the phenomenon of digital transformation is considered. A description of the UK practice of digital transformation of public administration is given. It is proposed to introduce in Ukraine the experience of the United Kingdom in the field of digital transformation of public administration.
Network communication as a technology of forming an educational standard for public servants
Authors: Sorokina Nataliia , Shelomovska Oksana
Published: September 2020

Theses of the report are devoted to the research of network communication and its introduction into the educational process of public servants. The main possibilities and advantages of network communication in the process of building a virtual educational environment are established. It is emphasized that network communications are a comfortable learning environment for many public servants, as they allow to optimize the cost of their own time and achieve a single goal, which is aimed at the educational process. It was found that the possibilities of network communications in the process of training public servants can be used to solve a variety of tasks: to effectively organize teamwork, long-term project activities, international exchanges; get the opportunity for continuing education and self-education, networking of people in different countries.