bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of kilohertz frequency, burst duty cycle and burst duration on evoked torque, discomfort and muscle efficiency: A randomized crossover trial
Authors: Modesto Karenina Arrais Guida , Raposo Priscila Karen Silva , da Silva Almeida Isabella , Vaz Marco Aurélio , Durigan João Luiz Quagliotti
Published: October 2024

Kilohertz‐frequency alternating currents (KFACs) have been indicated to minimize muscle atrophy and weakness. However, the optimal stimulation parameters still need to be determined.

Objective

This study aimed to investigate the effects of different KFACs on evoked torque, current efficiency, and perceived discomfort.

Design

KFACs with frequencies of 1 kHz (Aussie current) and 2.5 kHz (Russian current), along with two duty cycles (10% and 20%), were randomly applied to the triceps surae muscle of healthy participants using a crossover design. The NMES intensity, NMES‐evoked torque, NMES efficiency, and NMES discomfort were measured in maximal and submaximal conditions. Statistical analyses were conducted using a two‐way mixed‐model ANOVA with repeated measures. Forty‐four participants were included.

Results

Aussie currents produced higher evoked torque and efficiency in maximal and submaximal efforts, with higher perceived discomfort in maximal effort. Although the Australian current may cause greater discomfort at maximal efforts, it matches the Russian current in perceived discomfort at submaximal levels. The 20% duty cycle produced the highest efficiency in submaximal efforts.

Conclusion

In both maximal and submaximal efforts, the Aussie current demonstrated superior NMES efficiency, yielding higher torque with lower amplitude than the Russian current. Clinicians should take these findings into consideration when prescribing KFACs to optimize clinical outcomes.
The Turning Point in Time from the Serbian Perspective: How to Turn the Digital Tide
Authors: Sofronijević Adam
Published: October 2024

To compare and contrast two points in time the article highlights the social impact of the WWW that was still hidden in 1989 and the social impact of the disappearance of the reading of printed books that is still hidden in 2024. These global points of interest for turning the tide are supplemented by some particulars from a Serbian perspective and a question: should world governments buy time for people to read printed books?
A Note on the Optimal Speed of Transition: Aghion and Blanchard Revisited
Authors: Nævdal Eric , Wagner Martin
Published: October 2024

This note illustrates, by reconsidering the seminal optimal speed-of-transition model of Aghion, P., and O. J. Blanchard. (1994. “On the Speed of Transition in Central Europe.” NBER Macroeconomics Annual 9: 283–319), that optimal transition paths, in general, exhibit nonlinearities and discontinuities. Aghion and Blanchard consider only an approximate solution with a constant unemployment rate over the transition process. The exact solution features an increasing unemployment rate with a discontinuity when the state sector is closed down at the optimally chosen endpoint of transition. Economic transition problems bear many similarities to scrap value problems with free terminal time, often encountered in resource economics. In relation to the transition to a green economy, the discussion in this note therefore casts doubt on the optimality of a green transition discussed in, e.g., the European Union in terms of politically specified rather than optimally designed milestones for emissions reductions, i.e., by −55 % compared to 1990 levels until 2030 and net zero until 2050.
Global education – Impressive results of Ian Donald school
Authors: Kurjak Asim , Chervenak Frank A. , Stanojević Milan
Published: October 2024

The Ian Donald International School of Ultrasound bears testament to globalization in its most successful and worthwhile form. The school was founded in Dubrovnik in 1981. Since then, the growth has been meteoric and now consists of 126 branches throughout the world. The reason for this success has been the tireless and selfless efforts of the world’s leading authorities in ultrasound who are willing to dedicate their valuable time without reimbursement to teach sonologists and sonographers throughout the world. The teachers put national, religious, political, and other parochial considerations aside as they strive to improve the care of all women and fetal patients. Our politicians in all of the myriad countries represented in the school have much to learn from the purity of spirit that exists throughout the international family of Ian Donald schools. We believe that Ian Donald is smiling down from heaven at the School that bears his name. It is not overstating the fact to say that Donald’s innovation has changed the thinking of our age. The magnitude of this step alone is incalculable. Indeed, diagnostic ultrasound, more than any other modern technique, has made manifest that the fetus is an individual virtually from conception.
Biofluid biomarkers for Alzheimer’s disease: past, present, and future
Authors: An Chengyu , Cai Huimin , Ren Ziye , Fu Xiaofeng , Quan Shuiyue , Jia Longfei
Published: October 2024

Alzheimer’s disease (AD) is a gradually progressive neurodegenerative disease with tremendous social and economic burden. Therefore, early and accurate diagnosis is imperative for effective treatment or prevention of the disease. Cerebrospinal fluid and blood biomarkers emerge as favorable diagnostic tools due to their relative accessibility and potential for widespread clinical use. This review focuses on the AT(N) biomarker system, which includes biomarkers reflecting AD core pathologies, amyloid deposition, and pathological tau, as well as neurodegeneration. Novel biomarkers associated with inflammation/immunity, synaptic dysfunction, vascular pathology, and α-synucleinopathy, which might contribute to either the pathogenesis or the clinical progression of AD, have also been discussed. Other emerging candidates including non-coding RNAs, metabolites, and extracellular vesicle-based markers have also enriched the biofluid biomarker landscape for AD. Moreover, the review discusses the current challenges of biofluid biomarkers in AD diagnosis and offers insights into the prospective future development.
Mie metasurfaces for enhancing photon outcoupling from single embedded quantum emitters
Authors: Prescott Samuel , Iyer Prasad P. , Addamane Sadhvikas , Jung Hyunseung , Luk Ting S. , Brener Igal , Mitrofanov Oleg
Published: October 2024

Solid-state quantum emitters (QE) can produce single photons required for quantum information processing. However, their emission properties often exhibit poor directivity and polarisation definition resulting in considerable loss of generated photons. Here we propose and numerically evaluate Mie metasurface designs for outcoupling photons from an embedded and randomly-positioned QE. These Mie metasurface designs can provide over one order of magnitude enhancement in photon outcoupling with only several percent of photons being lost. Importantly, the Mie metasurfaces provide the enhancement in photon outcoupling without the need for strict QE position alignment and without affecting the intrinsic QE emission rate (Purcell enhancement). Electric dipole modes are key for achieving the enhancement and they offer a path for selective outcoupling for photons emitted with specific polarisation, including the out-of-plane polarisation. Mie metasurfaces can provide an efficient, polarisation-selective and scalable platform for QEs.
A novel investigation into time-fractional multi-dimensional Navier–Stokes equations within Aboodh transform
Authors: Almheidat Maalee , Yasmin Humaira , Al Huwayz Maryam , Shah Rasool , El-Tantawy Samir A.
Published: October 2024

This investigation explores the analytical solutions to the time-fractional multi-dimensional Navier–Stokes (NS) problem using advanced approaches, namely the Aboodh residual power series method and the Aboodh transform iteration method, within the context of the Caputo operator. The NS equation governs the motion of fluid flow and is essential in fluid dynamics, engineering, and atmospheric sciences. Given the equation’s extensive and diverse applicability across several disciplines, we are motivated to conduct a thorough analysis to understand the complex dynamics associated with the nonlinear events it describes. For this purpose, we effectively handle the challenges posed by fractional derivatives by utilizing the Aboodh approach. This will enable us to obtain accurate analytical approximations for the time fractional multi-dimensional NS equation. By conducting thorough analysis and computational simulations, we provide evidence of the efficiency and dependability of the suggested methodologies in accurately representing the dynamic behavior of fractional fluid flow systems. This work enhances our comprehension of the utilization of fractional calculus in fluid dynamics and provides valuable analytical instruments for examining intricate flow phenomena. Its interdisciplinary nature ensures that the findings are applicable to various scientific and engineering fields, making the research highly versatile and impactful.
School Counselors' Experiences and Growth in Responding to Cyberbullying among Middle School Students
Authors: Lee Min-Hye , Choi Jiyoung
Published: October 2024

The purpose of this study is to deeply explore the coping experiences of school counselors regarding cyberbullying among middle school students and their subsequent growth. To achieve this research objective, in-depth interviews were conducted with 20 school counselors who have experience in dealing with cyberbullying. The raw data was conceptualized and categorized using a continuous comparison method. In this study, data were analyzed using the method of grounded theory. As a result of open coding, 79 concepts, 21 subcategories, and 9 categories were derived and arranged in a paradigm model. The central phenomenon experienced by school counselors regarding cyberbullying among middle school students is ‘facing crisis situations,’ which includes ‘recognizing the limitations of the school counselor's role and the unfamiliarity of cyberspace.’ The analysis went through four stages, and the relationships between the categories were confirmed to classify participants into ‘complete rebirth growth type,’ ‘experiential growth type,’ ‘infrastructure-building rebirth type,’ and ‘incomplete rebirth growth type.’ This study is significant in that it provides educational and counseling implications for coping with cyberbullying by deeply exploring and concretizing the practical characteristics and actual appearances of school counselors' coping experiences with cyberbullying among middle school students.
Young Children’s Self-Perceived Playfulness: The Relationship with Teacher Assessments and Children’s Executive Functions
Authors: Ko Arum , Lee Wanjeong
Published: October 2024

This study investigates young children’s self-perceived playfulness and explores the association with playfulness as assessed by teachers and the children’s executive functions. A sample of 183 preschoolers from childcare centers in the metropolitan area was selected purposively for one-on-one assessments to measure the children’s perceived playfulness and executive functions. Teachers were also asked to evaluate the playfulness of the children. Descriptive statistics, correlation analysis, independent sample t-tests, one-way ANOVA, and partial correlation analysis were conducted on the collected data. The results indicated that children generally perceived themselves as highly playful, and this perception was partially correlated with the teachers’ evaluations. No gender differences were found in the children’s self-perceived playfulness, but there were significant age-related differences within the groups. Moreover, a significant correlation was found between the children’s self-perceived playfulness and their executive functions. The findings suggest that children’s self-perceptions of their playfulness are related to both teachers’ assessments and their own executive functioning, thereby generalizing the tendencies observed in previous research where playfulness was assessed by adults such as teachers or parents.
The Effects of Board Game Activities on the Improvement of Multiple Intelligence of Elementary School Students
Authors: Kim Jiwon , Au Yunkyung
Published: October 2024

The education of elementary school students promotes the overall development of children and induces a positive attitude toward learning. Board games that stimulate interest and motivation in learning have been widely used in recent years. In this study, a program is implemented for elementary school students attending after-school care centers to explore the effects on multiple intelligence using board games. As a result of verifying whether there is a difference in multiple intelligence between the experimental group and the control group after the board game, all areas were improved. However, in music intelligence and physical exercise intelligence, the improvement effect of the control group appeared. Therefore, other factors other than the effect of the board game must have worked. In other areas, there was a statistically significant difference between the two groups, demonstrating improved effectiveness through board game activities. In addition, by confirming that it is effective in maintaining and improving the strength intelligence in the experimental group, this study provides implications for the use of board games as a learning tool that induces children's interest and fun in the future.
Do Financial Regulation and Technology Matter in Fostering Green Growth?
Authors: Dyah Maya Nihayah  , Rahmayani Dwi , Afif Dhia Pratama  , Fredericho Mego Sundoro  , Hermanto Agus
Published: October 2024

Effective regulation and technological innovation are key factors in driving the implementation of green growth initiatives. This research investigates how financial regulation and technological innovation influence green growth, proxied by carbon productivity, with data from 1996 to 2020 across ASEAN-5 Countries. A Panel Dynamic Ordinary Least Square (DOLS) model is conducted to analyze the long-run effect on each variable. The result showed that financial regulation, proxied by regulatory quality and economic freedom, positively and significantly influences green growth. Meanwhile, technological innovation has a positive but not significant influence on green growth. According to the findings, this study proposes adopting top-tier regulations and a step-by-step approach to realizing green growth. Meanwhile, the government can also open an investment as funding to improve innovation in green technology
The Role of Public Figures amidst Indonesia’s Early Social Restrictions Policy on Twitter (X): A Social Network Analysis
Authors: Setiadi Tatak , Pamuji Eko
Published: October 2024

The Government of Indonesia implemented large-scale social restrictions (Indonesian: Pembatasan Sosial Berskala Besar, abbreviated as PSBB) following the first confirmed cases of COVID-19. Due to social media role in information propagation, this decision quickly became a trending topic on Twitter. This study investigates the main actors and the dynamics of these discussions surrounding PSBB. Utilizing RStudio software, tweets containing the keyword „psbb“ and the hashtag #psbb were mined as of May 6, 2020. The data were analyzed and compared with research conducted during May 2020. Key findings include the significant role of the musician Fiersa Besari in shaping discussions about social restrictions, the emergence of seven major opinion leaders, and the prominence of online news outlets like detikcom and CNN Indonesia in the conversation. Additionally, the study highlights critical commentary from actors affiliated with the Democratic Faction of the Indonesian House of Representatives regarding the government‘s social restrictions policies. These findings provide insights into the network dynamics and public opinion on social restrictions during the early social restrictions policy in Indonesia.
Metaphor analysis of early childhood teachers' rights for children
Authors:   Research Institute for Early Childhood Education - Korea National University of Education, Koh Yoon-hee , Kim In-ae
Published: October 2024

The purpose of this study is to analyze the metaphors of children's rights of early childhood teachers and examine their awareness and values of children's rights. To this end, from the first week of March 2024 to the fourth week of April 2024, we collected and analyzed metaphors of children's rights through an open-ended questionnaire targeting 190 early childhood teachers living in G City and G Province for approximately two months. The results of the study are as follows. First, from the adult's perspective, children's rights were expressed as ‘children's lives themselves’ and ‘our collective efforts’. Second, from the perspective of viewing children, they were expressed as ‘children as rights holders’ and ‘children as socially vulnerable’. Finally, from the teacher's perspective, they were expressed as ‘teachers as duty-bearers’ and ‘teachers who must make social efforts’, and were classified into three categories in total. Through this study, we examined early childhood teachers' awareness of children's rights and suggested implications for the direction of desirable implementation of children's rights.
An Analysis of domestic research trends on artificial intelligence in early childhood education field
Authors:   Research Institute for Early Childhood Education - Korea National University of Education, Kim Young Ah , Park Daeun
Published: October 2024

This study was conducted to analyze the trends of AI-related papers published in the field of early childhood education. Using the keywords ‘artificial intelligence’, ‘early childhood’, ‘education’, and ‘robot’ in combination, academic journal articles and dissertations published in Korea after 2023 were retrieved from RISS. Based on the selection criteria, the number of papers by year, research subjects, research methods, and topics were calculated, and the results were analyzed by subject. In 2023, 24 papers were published, and by June 2024, 15 papers had been published. The main research subjects were in-service teachers, followed by pre-service teachers, and children, with relatively fewer studies targeting parents. Studies on program and scale development, as well as theoretical reviews, were also published. Quantitative research was the most common research method, with survey research being the most frequently conducted among the quantitative studies. By topic, there were many studies on perceptions of artificial intelligence, followed by program application and theoretical reviews. The results were analyzed in detail by research topic. This study is significant in that it provides basic data for AI education in the educational field by examining trends in AI-related research in the field of early childhood education published since 2023, and offers insights on future research topics needed in the academic field.
Avaliação de intervenções psicodinâmicas e cognitivocomportamentais no processo terapêutico
Authors: Röhnelt Ramires Vera Regina , Brusius Brenner Eduardo , Dionísio Ffner Gabriela , Kirsch Bergonsi Luísa
Published: October 2024

A pesquisa sobre processo terapêutico demanda instrumentos capazes de avaliar os constructos que serão o foco de análise. A técnica e as intervenções do terapeuta têm sido consideradas um fator específico do processo, e seu estudo requer instrumentos válidos e confiáveis. O objetivo deste estudo foi desenvolver a adaptação transcultural da Comparative Psychotherapy Process Scale (CPPS) para o português brasileiro, avaliar sua confiabilidade e evidências de validade. Foi examinada a validade de conteúdo da versão adaptada, e o estudo piloto analisou videotapes de 204 sessões de quatro psicoterapias psicodinâmicas de crianças. Análises de fidedignidade interavaliadores e análises de validade, buscando identificar evidências baseadas na estrutura interna (análise fatorial e análise de consistência interna) e baseadas nas relações com outras variáveis (validade convergente) também foram realizadas. Os resultados obtidos com a versão adaptada apresentaram ótima fidedignidade intervaliadores, validade convergente com o Child Psychotherapy Q-Set, e evidências preliminares de validade de constructo, em relação a uma das subescalas da CPPS.
The Mediating Effect of Self-Encouragement and Emotional Regulation Ability in the Relationship between Parental Empathy and School Life Adaptation Perceived by Middle School Students
Authors: Cho Hye-Kyoung , Cho Gyu-Pan
Published: October 2024

The purpose of this study is to increase school life adaptation by confirming the mediating effects of self-encouragement and emotional regulation ability in middle school students' parental empathy and school life adaptation. To this end, 233 middle school students in Busan and Gyeongnam were surveyed, and the data were analyzed with SPSS Ver 27.0. Correlation analysis between variables was conducted, hierarchical multiple regression analysis was conducted to verify the mediating effects of self-encouragement and emotional regulation ability, and significance was verified by the method of bootstrapping. The results of the study are as follows. First, there was a positive correlation between parental empathy, self-encouragement, emotional regulation ability, and school life adaptation perceived by middle school students. Second, there was a complete mediating effect on self-encouragement and emotional regulation ability in middle school students' parental empathy and school life adaptation, and emotional regulation ability had a partial mediating effect. These results suggest the importance of self-encouragement and emotional regulation ability that influence middle school students' adaptation to school life through parental empathy.
Difference between ChatGPT Learning Use and ChatGPT Teaching Use Recognized by College Students
Authors: Oh Bangsil , Kwon Young-Ae
Published: October 2024

The purpose of this research is to identify the difference in perception of college students between ChatGPT learning use area and ChatGPT teaching use area. A total of 114 respondents were analyzed. The results show that the purpose of ChatGPT use appeared in the order of data research and information collection, curiosity solving, tasks, and idea generation. Second, the advantages perceived by college students were in the order of various information collection, efficient time saving, quick information acquisition, summary and quick answers/problem solving. The limitations in using ChatGPT were in the order of inaccurate answers, difficulty in generating questions, reliability of answers, reduced user thinking skills, and uniform products. Third, the learning areas in which ChatGPT can be used were translation and content summary, while the teaching areas that college students think instructors can use ChatGPT were in the order of vocabulary/grammar correction, and translation. The overall average difference in the use of ChatGPT between instructors and learners perceived by college students was statistically significant. There were significant differences between teaching use and learning use in order or feedback provision, data research and information collection, idea/topic generation, outline writing, translation, and content summary. Therefore, this study is meaningful in that it revealed that there is a difference between the ChatGPT use of learners and that of instructors recognized by college students.
AERODYNAMICS OF INDUSTRIAL BUILDINGS
Authors: Petrov V. , Gоncharenko D. , Zhdanov O.
Published: October 2024

The design of metal silos and other structures (towers, silo galleries) of the grain receiving point under the influence of wind load is considered in the work. The positive and negative aspects of the structures of the silos under consideration have been identified. The method of researching wind load on silos in the ANSYS CFX package was applied. A three-dimensional model of industrial buildings was made and, taking into account the recommendations, the estimated volume around the research object was adopted. The volume for air movement around industrial buildings is also defined. Taking into account the method of finite elements, a grid was built on the layout of the research object. Assigned initial data and boundary conditions. The structure of six metal silos with a diameter of 15.2 m and a height of a cylindrical wall of 12 m of the Drokiivskyi HPP (Republic of Moldova) was taken as the object of the study. Wind pressure on cylindrical walls and conical roofs is estimated by the finite element method using the ANSYS CFX package for wind direction perpendicular to the line of silos at maximum speed. Pressure isobars are found in various auxiliary vertical and horizontal planes. Lines of equal air flow velocities and their vector analogues are constructed. Zones of maximum and minimum pressure on industrial facilities have been established. The correspondence of the general picture of the pressure distribution along the wall in the circumferential direction when the aerodynamic coefficient changes is established. Determined wind loads on structural elements of industrial buildings. Calculations were performed using the functional calculator built into this ANSYS CFX package. To verify the numerical consistency of the obtained results, additional research is required. Due to the movement (animation) of auxiliary vertical planes, it is possible to consider the dynamics of changes in pressure and velocity of the incoming air flow in the calculated volume.
Rational homotopy type and nilpotency of mapping spaces between Quaternionic projective spaces
Authors: Abebaw Tilahun , Gatsinzi Jean-Baptiste , Yeruk Smegnsh Demelash
Published: October 2024

The rational homotopy type of a mapping space is a way to describe the structure of the space using the algebra of its homotopy groups and the differential graded algebra of its cochains. An L∞-model is a graded Lie algebra with a family of higher-order brackets satisfying the generalized Jacobi identity and antisymmetry. It can be used to study the rational homotopy type of a space. The nilpotency index of an L∞-model is useful in understanding a space's algebraic structure. In this paper, we compute the rational homotopy type of the component of some mapping spaces between projective spaces and determine the nilpotency index of corresponding L∞-models.
LEPR isoform expression changes in local fat depots in coronary atherosclerosis and acquired heart defects
Authors: Gorbatovskaya E. E. , Belik E. V. , Dyleva Yu. A. , Uchasova E. G. , Ponasenko A. V. , Fanaskova E. V. , Stasev A. N. , Gruzdeva O. V.
Published: October 2024

Aim. To evaluate the expression of leptin receptor isoforms in local fat depots in patients with coronary artery disease (CAD) and acquired heart defects (AHDs).

Material and methods. The study included 120 patients with CAD. The comparison group consisted of 96 patients with degenerative aortic stenosis (AS). Expression of six leptin receptor isoforms (LEPR1, LEPR2, LEPR2/2, LEPR3, LEPR3/2, LEPR4) was assessed using quantitative real-time polymerase chain reaction in subcutaneous (SAT), epicardial (EAT) and perivascular (PVAT) adipose tissue. Statistical processing was carried out using the Statistica 10.0 and SPSS 17.0 for Windows software package.

Results. In EAT, minimal expression of LEPR1, LEPR2, LEPR2/2, LEPR3, LEPR3/2, LEPR4 was detected relative to SAT and PVAT in the group of CAD patients. In patients with CAD, mRNA levels of six LEPR isoforms were lower than in patients with AS. In indi­viduals with AHDs, a decrease in the expression of LEPR1, LEPR2, LEPR2/2, LEPR3, LEPR3/2, LEPR4 in SAT relative to EAT and PVAT was recorded. However, only the LEPR1 and LEPR2 isoforms were significantly lower in SAT in patients with AS when com­pared with patients with CAD. In PVAT, the maximum mRNA levels of six LEPR isoforms were found in both groups. There were no significant differences in LEPR1, LEPR2, LEPR2/2, LEPR3, LEPR3/2, LEPR4 expression between patients with CAD and AHDs.

Conclusion. Patients with CAD are characterized by a marked decrease in the expression of six LEPR isoforms in EAT. A decrease in the expression of studied LEPR isoforms in EAT is associated with impaired adipogenesis, adipocyte hypertrophy, insulin resistance, increased proinflammatory factors, hyperleptinemia, and progression of atherosclerosis. The identified features of EAT in patients with СФВ can probably have both local and systemic negative effects on the cardiovascular system.
Atherosclerotic plaque structure according to optical coherence tomography in patients with coronary artery disease living in extreme weather conditions
Authors: Utegenov R. B. , Sapozhnikov S. S. , Bessonov I. S.
Published: October 2024

Aim. To evaluate the plaque structural features in patients with coronary artery disease (CAD) permanently residing in the Far North of the Tyumen region in com­parison with patients in the South of the Tyumen region.

Material and methods. This pilot case-control study included 32 patients with stable CAD (mean age 62,7±8,9 years, 24 (75%) men). The main group consisted of 16 patients permanently residing in the Far North of Tyumen region (non-indi­ge­nous population), while the comparison group consisted of 16 patients permanently residing in the South of the Tyumen region. In all patients, CAD was verified using paraclinical diagnostic methods. All patients underwent optical coherence tomography (OCT), according to which the plaque type was analyzed. The following plaque types were distinguished: fibrous, fibroatheroma, calcified fibroatheroma, thin-cap fibroatheroma (TCFA). TCFA was defined as the presence of a fibrous cap ≤65 μm thick and an arc of the necrotic core of at least 90о. In addition, a lipid-rich plaque was isolated, which was determined by a lipid arc of more than 180о.

Results. According to clinical and angiographic characteristics, patients in the compared groups were statistically comparable. A total of 134 plaques were analyzed from 32 patients (main group — 65 plaques; control group — 69 plaques (p>0,05)). The most common plaque type in both groups was calcified fibroatheroma (46,2% in the Far North group and 50,7% in the South group, p=0,609). TCFA was significantly more often detected in patients living in far north (33,8% vs 17,4%, p=0,031). In this group of patients, thin (<65 µm) fibrous plaque cap was also more often determined (35,4% vs 18,8%, p=0,034). Lipid-rich plaques in both groups was determined with the same frequency (56,9% vs 62,3%, p=0,598).

Conclusion. In patients with verified CAD living in extreme weather conditions, according to OCT, TCFA was more often determined, which could potentially be associated with a higher risk of adverse cardiovascular events.
Pathogenesis and clinical significance of reperfusion arrhythmias in acute myocardial infarctio
Authors: Oleynikov V. E. , Chernova A. A. , Averyanova E. V. , Kulyutsin A. V.
Published: October 2024

The problem of ischemia-reperfusion injury, in particular, reperfusion arrhythmias, has remained controversial for many years. To date, there are no one frame of mind on the clinical and prognostic significance of tachyarrhythmias in the acute period of myocardial infarction. In addition, data on the incidence of reperfusion arrhythmias and related mortality are very contradictory. The review summarizes current concepts and results of studies devoted to the study of the clinical role of reperfusion arrhythmias. Their pathogenesis, structure, and impact on the long-term prognosis of patients are discussed. The need to study ischemia-reperfusion injury within the pharmacoinvasive strategy using modern thrombolytic agents is emphasized, which seems especially relevant given the Russian geographical features.
Method of thromboembolism prediction in advanced atherosclerosis
Authors: Bykov A. V.
Published: October 2024

Aim. To develop a method for thromboembolism prediction in patients with ad­vanced atherosclerosis.

Material and methods. The study involved 170 patients with advanced atheroscle­rosis and 110 patients with local atherosclerotic lesions. At the first stage, speciali­zed experts generated signs characterizing the severity of prothrombotic conditions. To determine whether patients belonged to the first or second group, the multivariate statistics method was used. Decision rules (DRs) was developed based on soft computing (SC), as well as the methodology for the synthesis of hybrid fuzzy DRs.

Results. According to the discriminant function coefficient (DFC), the division into classes was made with the formation of an intersection area, which affected the diagnostic sensitivity of this method (=86%). Due to difficulties of separating more heterogeneous groups with a small sample, RP was synthesized according to the atherosclerosis severity classification using SC technology. Atherosclerosis severity classification was adopted according to fuzzy DRs: initiation stage (up to 20%); reverse stage (21-40%); progressive stage (41-65%); critical stage (more than 65%). As­ses­sment of thromboembolism risk in advanced atherosclerosis in the examined pati­ents showed the following trends: progressive stage — 55% of patients; critical stage — 21% of patients; reverse stage — 16% of patients; initiation stage — 7% of patients.

Conclusion. DFC for DRs makes it possible to identify groups with high and low thromboembolism risk. The resulting final fuzzy DRs make it possible to differentiate the atherothrombotic condition in advanced atherosclerosis by severity, which can help to timely determine preventive and therapeutic measures.
Surgical treatment of a newborn with critical aortic coarctation using palliative stenting: a case report
Authors: Lyapin A. A. , Shushpannikov P. A. , Khalivopulo I. K. , Tarasov R. S.
Published: October 2024

Introduction. Coarctation of the aorta (CoA) is a congenital severe narrowing of the aortic isthmus, which in turn is often accompanied by impaired organ perfusion or even cardiogenic shock. In newborns with critical CoA in the case of patent ductus arteriosus (PDA) closure, the clinical condition of patients with this congenital heart defect (CHD) sharply worsens and leads to multiple organ failure. In this group of children, mortality ranges from 30 to 50% of infant mortality from CHD. This case demonstrates the positive effect of palliative stenting of a narrowed section of the aorta, which made it possible to safely perform radical surgery for CHD.

Case description. Nine-year-old male patient with body weight of 3,5 kg and body length of 53 cm was admitted to the clinic with a diagnosis of CHD: Critical CoA. Secundum atrial septal defect. PDA. Multiple organ failure. Taking into account the severe comorbidity status in the form of multiple organ failure, the high risk of necrotizing enterocolitis, case conference decided to perform a step-by-step CHD treatment as follows: palliative endovascular stenting of critical CoA, followed by radical surgery after stabilization of the patient's condition. The plan was successfully implemented.

Conclusion. Сritical CoA stenting can be used as a bridge to radical surgery of the defect in newborns with multiple organ failure. This palliative intervention helps to stabilize the child for up to 3 weeks and more safely perform radical surgery of CoA.
Identification of Potential Glucocorticoid Receptor Therapeutic Targets in Multiple Myeloma
Authors: Thomas Alexandra L. , Coarfa Cristian , Qian Jun , Wilkerson Joseph J. , Rajapakshe Kimal , Krett Nancy L. , Gunaratne Preethi H. , Rosen Steven T.
Published: October 2024

Glucocorticoids (GC) are a cornerstone of combination therapies for multiple myeloma. However, patients ultimately develop resistance to GCs frequently based on decreased glucocorticoid receptor (GR) expression. An understanding of the direct targets of GC actions, which induce cell death, is expected to culminate in potential therapeutic strategies for inducing cell death by regulating downstream targets in the absence of a functional GR. The specific goal of our research is to identify primary GR targets that contribute to GC-induced cell death, with the ultimate goal of developing novel therapeutics around these targets that can be used to overcome resistance to GCs in the absence of GR. Using the MM.1S glucocorticoid-sensitive human myeloma cell line, we began with the broad platform of gene expression profiling to identify glucocorticoid-regulated genes further refined by combination treatment with phosphatidylinositol-3'-kinase inhibition (PI3Ki). To further refine the search to distinguish direct and indirect targets of GR that respond to the combination GC and PI3Ki treatment of MM.1S cells, we integrated 1) gene expression profiles of combination GC treatment with PI3Ki, which induces synergistic cell death; 2) negative correlation between genes inhibited by combination treatment in MM.1S cells and genes over-expressed in myeloma patients to establish clinical relevance and 3) GR chromatin immunoprecipitation with massively parallel sequencing (ChIP-Seq) in myeloma cells to identify global chromatin binding for the glucocorticoid receptor (GR). Using established bioinformatics platforms, we have integrated these data sets to identify a subset of candidate genes that may form the basis for a comprehensive picture of glucocorticoid actions in multiple myeloma. As a proof of principle, we have verified two targets, namely RRM2 and BCL2L1, as primary functional targets of GR involved in GC-induced cell death..
State parameter predictions based on cone penetration test simulated with MPM: an application to tailing deposits
Authors: Martinelli M. , Remmerswaal G. , Reid D.
Published: October 2024

The ‘state parameter’, which compares the current void ratio with the critical state void ratio, plays a crucial role in quantifying sandy soil behaviour. In situ methods, such as cone penetration tests (CPTs), can quantify the mechanical state of sand. However, establishing a direct relationship between cone resistance and the state parameter requires a complex back-analysis of the processes occurring in the soil during the test. Currently, a cavity expansion solution is being used to relate the state parameter to the cone resistance, necessitating the use of a calibrated scaling equation. In this study, 600 material point method CPT simulations are performed – which employ the critical state NorSand model – to derive a direct predictive equation for estimating the state parameter from CPTs. This eliminates the need for a scaling equation. The predictive equation computes cone resistance as a function of the NorSand parameters and the state parameter of the soil. The accuracy of this predictive equation is subsequently evaluated by comparing the results against the chamber test data of tailings deposits, showing promising performance.
Líneas conceptuales de la ética para la interpretación contemporánea-cotidiana de la sociedad
Authors:   Universidad Bolivariana del Euador, RODRÍGUEZ CAGUANA Tomas Humberto
Published: October 2024

Este artículo aborda el problema de la ética y su constitución como eje individual y colectivo a través de la historia y en sus actuales (re)significaciones, (re)interpretaciones y (re)orientaciones. Tiene por objetivo establecer las líneas conceptuales éticas que permitan una interpretación holística y contemporánea de la sociedad en el segundo cuartil del actual siglo. La premisa de este artículo es que la constitución de las plataformas éticas para la sociedad en el siglo XXI tiene la complejidad de una hiperfragmentación social y el desafío de la promesa de la hibridación “Ser-máquina”. Técnicas: Investigación Bibliográfica. Análisis de Contenido.
Aumento da maturidade de equipes SCRUM de desenvolvimento de software
Authors:   CEETEPS - Centro Estadual de Educação Tecnológica Paula Souza, Camargo Klauren Godoi Araújo , Galegale Napoleão Verardi ,   CEETEPS - Centro Estadual de Educação Tecnológica Paula Souza
Published: October 2024

A adoção de métodos ágeis no desenvolvimento de software vem aumentando a cada ano. Muito tem sido investido na preparação e capacitação de equipes neste sentido. O presente estudo desenvolve um roadmap para apoiar equipes scrum na evolução em níveis de maturidade ágil como instrumento complementar a um diagnóstico de níveis de maturidade desenvolvido e utilizado por uma instituição financeira brasileira de grande porte. Objetiva avaliá-lo quanto à usabilidade, factibilidade e utilidade por meio de demonstração em equipes e com grupo focal de especialistas em agilidade. Utilizou método de pesquisa Design Science Research Methodology (DSRM) e métodos complementares: survey, pesquisa bibliográfica, estudos de campo e entrevistas semiestruturadas para desenvolvimento e avaliação. O roadmap foi considerado pelas equipes participantes da demonstração e especialistas como de fácil usabilidade, factível e útil como apoio para adoção de práticas ágeis que contribuem para elevação de maturidade ágil para as equipes scrum da instituição financeira.
Inteligencia artificial en el estudio del uso de escaneo cerebral en la implementación en usuarios neurodivergentes
Authors:   Universidad Autónoma de Querétaro, Dwyer Mateo
Published: October 2024

La salud mental en general es un tema que ha ganado mucha relevancia e importancia en los últimos años. Pero un elemento central de ésta es el tema de trastornos mentales, y el diagnóstico de ellos. Por mucho tiempo, el método estándar usado para este proceso ha sido lento y costoso. Sin embargo, con nuevas tecnologías como son la inteligencia artificial y el escaneo cerebral hay posibilidad de una detección más rápida, sencilla, y objetiva de estos trastornos, incluido a edades más tempranas. El objetivo de este estudio es verificar la eficacia del reconocimiento de patrones eléctricos cerebrales mediante la inteligencia artificial en el uso médico psicológico, utilizando opiniones profesionales para determinar su factibilidad. El análisis fue cuanti-cualitativo, y se encontró que estas herramientas probablemente serán indispensables para esta área en el futuro cercano, siempre y cuando se le de un enfoque particular a su desarrollo.
Los sistemas de información y su influencia en las estrategias ambientales y el rendimiento organizacional
Authors:   Universidad La Salle Victoria, Meléndez Ruiz Enrique Ismael , Almazán Demian Abrego ,   niversidad Autónoma de Tamaulipas, Quintero José Melchor Medina ,   niversidad Autónoma de Tamaulipas
Published: October 2024

La inquietud sobre el deterioro ambiental ha crecido de manera alarmante, ante ello. las empresas se han visto presionadas por aplicar procesos tecnológicos que cumplan con aspectos ambientales, siendo los sistemas de información con enfoque verdes uno de ellos. El objetivo del estudio es analizar cómo los sistemas de información verdes (SIV) influyen en las estrategias ambientales y en el rendimiento organizacional de las empresas manufactureras mexicanas. En el estudio cuantitativo se analizó un modelo jerárquico de segundo orden, mediante Modelado de Ecuaciones Estructurales basado en mínimos cuadrados parciales (PLS). La muestra recolectada fue de 99 gerentes de empresas medianas y grandes mediante un cuestionario. Se detecta que los SIV juegan un papel crucial en el crecimiento de las empresas, como herramienta para mejorar sus operaciones y al aspecto económico mediante la reducción de costos, pero al mismo tiempo, a cuestiones ambientales al tener la capacidad de reducir la contaminación emitida.
A Better Way of Understanding the US Consumer: Decomposing Retail Sales by Household Income
Authors: Hacioglu Hoke Sinem , Feler Leo , Chylak Jack
Published: October 2024

Changes in retail spending reflect changes in consumer demand for goods. For the past several months, retail sales estimates published by the Census Bureau have indicated that consumer demand for retail goods remains resilient. However, published measures do not provide details on which consumers’ spending has remained resilient. Using a detailed micro dataset, we construct a measure of average retail spending for low-, middle- and high-income households.
Estimating SME numbers within cities and agglomerations: Applying machine learning methods to Russian data
Authors:   Institute of Applied Economic Research of the RANEPA, Radchenko Daria M. , Ponomarev Yuri Yu. ,   Institute of Applied Economic Research of the RANEPA,   Gaidar Institute for Economic Policy, Rostislav Kirill V. ,   Institute of Applied Economic Research of the RANEPA
Published: October 2024

Introduction: the development of agglomerations, which, as research shows, are becoming productivity growth poles, is one of the priorities in the spatial development policy in Russia. Despite numerous discussions, the term “urban agglomeration” is currently absent in federal legislation, but it is widely used in the regulatory framework at other levels of government. This leads to a lack of coordinated, accurate, and up-to-date information on the size and structure of agglomerations, thus bringing forward the need to formulate a well-based approach to identify their economic and geographical boundaries. Objectives: developing an approach to identify the boundaries of agglomerations in Russia, considering the spatial distribution of economic activity. Methods: machine learning, statistical analysis. The use of these methods makes it possible to identify the boundaries of agglomeration with high accuracy using open data on the height of the urban area. Results: the article presents the results of spatial clustering algorithm (DBSCAN) testing on residential development data in Russia; a list of “sustainable municipalities clusters” defining the agglomerations boundaries has been identified and estimates have been made for the number and revenue of firms and SMEs within the largest cities and agglomerations boundaries defined both analytically and formally in regulatory documents. Using the example of individual regions and average data for Russia, it has been shown that the number of firms (total and those registered as SME) within agglomerations can be underestimated by more than one-third and total revenues – by almost 60 %. Conclusions: considering sustainable municipalities clusters can improve the accuracy of agglomeration effects and business activity estimates and contribute to the formation of more accurate government support measures.
El método histórico en diálogo con las fuentes primarias: algunas preguntas al oficio del investigador
Authors: Agudelo Agudelo Carlos Alberto
Published: October 2024

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