bluuebunny/crossref_metadata_2025 huggingface dataset:
Functionalization of and through Melanin: Strategies and Bio-Applications
Authors: Mavridi-Printezi Alexandra , Menichetti Arianna , Mordini Dario , Montalti Marco
Published: June 2023

A unique feature of nanoparticles for bio-application is the ease of achieving multi-functionality through covalent and non-covalent functionalization. In this way, multiple therapeutic actions, including chemical, photothermal and photodynamic activity, can be combined with different bio-imaging modalities, such as magnetic resonance, photoacoustic, and fluorescence imaging, in a theragnostic approach. In this context, melanin-related nanomaterials possess unique features since they are intrinsically biocompatible and, due to their optical and electronic properties, are themselves very efficient photothermal agents, efficient antioxidants, and photoacoustic contrast agents. Moreover, these materials present a unique versatility of functionalization, which makes them ideal for the design of multifunctional platforms for nanomedicine integrating new functions such as drug delivery and controlled release, gene therapy, or contrast ability in magnetic resonance and fluorescence imaging. In this review, the most relevant and recent examples of melanin-based multi-functionalized nanosystems are discussed, highlighting the different methods of functionalization and, in particular, distinguishing pre-functionalization and post-functionalization. In the meantime, the properties of melanin coatings employable for the functionalization of a variety of material substrates are also briefly introduced, especially in order to explain the origin of the versatility of melanin functionalization. In the final part, the most relevant critical issues related to melanin functionalization that may arise during the design of multifunctional melanin-like nanoplatforms for nanomedicine and bio-application are listed and discussed.
Symbiotic Bacteria Modulate Lymantria dispar Immunity by Altering Community Proportions after Infection with LdMNPV
Authors: Zhao Peixu , Rensing Christopher , Wang Dun
Published: June 2023

The symbiotic bacteria–insect interaction is considered to be associated with immunity and drug resistance. However, the wide variety of insect species and habitats is thought to have a significant impact on the symbiotic community, leading to disparate results. Here, we demonstrated that symbiotic bacteria regulated the immune response by changing the proportion of the Gram-positive and the Gram-negative bacterial community in Lymantria dispar (L. dispar) after infection with its viral pathogen, L. dispar Nucleopolyhedrovirus (LdMNPV). After oral infection, the immune deficiency pathway was activated immediately, and the expression of Relish was up-regulated to promote the secretion of antimicrobial peptides. Meanwhile, the abundance of the Gram-negative bacterial community increased at the same time. Moreover, the Toll pathway was not regulated in the same way as the Imd pathway was after infection. However, the change in the Toll pathway’s expression remained positively correlated to the abundance of Gram-positive bacteria. This finding implied that the ratio of Gram-negative to Gram-positive bacteria in the LdMNPV infected larvae had an effect on the immune response. Our findings revealed that the immune regulation of L. dispar was regulated by the relative abundance of its symbiotic bacteria at different infection times with LdMNPV, which provides a new way to understand symbiotic bacteria–insect interactions.
Modulation of Insulin Amyloid Fibrillization in Imidazolium-Based Ionic Liquids with Hofmeister Series Anions
Authors: Vanik Vladimir , Bednarikova Zuzana , Fabriciova Gabriela , Wang Steven S.-S. , Gazova Zuzana , Fedunova Diana
Published: June 2023

Amyloid fibrils have immense potential to become the basis of modern biomaterials. The formation of amyloid fibrils in vitro strongly depends on the solvent properties. Ionic liquids (ILs), alternative solvents with tunable properties, have been shown to modulate amyloid fibrillization. In this work, we studied the impact of five ILs with 1-ethyl-3-methylimidazolium cation [EMIM+] and anions of Hofmeisterseries hydrogen sulfate [HSO4−], acetate [AC−], chloride [Cl−], nitrate [NO3−], and tetrafluoroborate [BF4−] on the kinetics of insulin fibrillization and morphology, and the structure of insulin fibrils when applying fluorescence spectroscopy, AFM and ATR-FTIR spectroscopy. We found that the studied ILs were able to speed up the fibrillization process in an anion- and IL-concentration-dependent manner. At an IL concentration of 100 mM, the efficiency of the anions at promoting insulin amyloid fibrillization followed the reverse Hofmeister series, indicating the direct binding of ions with the protein surface. At a concentration of 25 mM, fibrils with different morphologies were formed, yet with similar secondary structure content. Moreover, no correlation with the Hofmeister ranking was detected for kinetics parameters. IL with the kosmotropic strongly hydrated [HSO4−] anion induced the formation of large amyloid fibril clusters, while the other kosmotropic anion [AC−] along with [Cl−] led to the formation of fibrils with similar needle-like morphologies to those formed in the IL-free solvent. The presence of the ILs with the chaotropic anions [NO3−] and [BF4−] resulted in longer laterally associated fibrils. The effect of the selected ILs was driven by a sensitive balance and interplay between specific protein–ion and ion–water interactions and non-specific long-range electrostatic shielding.
Neurological Pupillary Index and Disposition at Hospital Discharge following ICU Admission for Acute Brain Injury
Authors: Lele Abhijit V. , Wahlster Sarah , Khadka Sunita , Walters Andrew M. , Fong Christine T. , Blissitt Patricia A. , Livesay Sarah L. , Jannotta Gemi E. , Gulek Bernice G. , Srinivasan Vasisht , Rosenblatt Kathryn , Souter Michael J. , Vavilala Monica S.
Published: June 2023

We examined the associations between the Neurological Pupillary Index (NPi) and disposition at hospital discharge in patients admitted to the neurocritical care unit with acute brain injury (ABI) due to acute ischemic stroke (AIS), spontaneous intracerebral hemorrhage (sICH), aneurysmal subarachnoid hemorrhage (SAH), and traumatic brain injury (TBI). The primary outcome was discharge disposition (home/acute rehabilitation vs. death/hospice/skilled nursing facility). Secondary outcomes were tracheostomy tube placement and transition to comfort measures. Among 2258 patients who received serial NPi assessments within the first seven days of ICU admission, 47.7% (n = 1078) demonstrated NPi ≥ 3 on initial and final assessments, 30.1% (n = 680) had initial NPI < 3 that never improved, 19% (n = 430) had initial NPi ≥ 3, which subsequently worsened to <3 and never recovered, and 3.1% (n = 70) had initial NPi < 3, which improved to ≥3. After adjusting for age, sex, admitting diagnosis, admission Glasgow Coma Scale score, craniotomy/craniectomy, and hyperosmolar therapy, NPi values that remained <3 or worsened from ≥3 to <3 were associated with poor outcomes (adjusted odds ratio, aOR 2.58, 95% CI [2.03; 3.28]), placement of a tracheostomy tube (aOR 1.58, 95% CI [1.13; 2.22]), and transition to comfort measures only (aOR 2.12, 95% CI [1.67; 2.70]). Our study suggests that serial NPi assessments during the first seven days of ICU admission may be helpful in predicting outcomes and guiding clinical decision-making in patients with ABI. Further studies are needed to evaluate the potential benefit of interventions to improve NPi trends in this population.
Relationships between Cerebral Vasculopathies and Microinfarcts in a Community-Based Cohort of Older Adults
Authors: Sin Mo-Kyung , Cheng Yan , Roseman Jeffrey M. , Zamrini Edward , Ahmed Ali
Published: June 2023

Cerebral microinfarcts are associated with cognitive impairment and dementia. Small vessel diseases such as cerebral arteriolosclerosis and cerebral amyloid angiography (CAA) have been found to be associated with microinfarcts. Less is known about the associations of these vasculopathies with the presence, numbers, and location of microinfarcts. These associations were examined in the clinical and autopsy data of 842 participants in the Adult Changes in Thought (ACT) study. Both vasculopathies were categorized by severity (none, mild, moderate, and severe) and region (cortical and subcortical). Odds ratios (OR) and 95% CIs for microinfarcts associated with arteriolosclerosis and CAA adjusted for possible modifying covariates such as age at death, sex, blood pressure, APOE genotype, Braak, and CERAD were estimated. 417 (49.5%) had microinfarcts (cortical, 301; subcortical, 249), 708 (84.1%) had cerebral arteriolosclerosis, 320 (38%) had CAA, and 284 (34%) had both. Ors (95% CI) for any microinfarct were 2.16 (1.46–3.18) and 4.63 (2.90–7.40) for those with moderate (n = 183) and severe (n = 124) arteriolosclerosis, respectively. Respective Ors (95% CI) for the number of microinfarcts were 2.25 (1.54–3.30) and 4.91 (3.18–7.60). Similar associations were observed for cortical and subcortical microinfarcts. Ors (95% Cis) for the number of microinfarcts associated with mild (n = 75), moderate (n = 73), and severe (n = 15) amyloid angiopathy were 0.95 (0.66–1.35), 1.04 (0.71–1.52), and 2.05 (0.94–4.45), respectively. Respective Ors (95% Cis) for cortical microinfarcts were 1.05 (0.71–1.56), 1.50 (0.99–2.27), and 1.69 (0.73–3.91). Respective Ors (95% Cis) for subcortical microinfarcts were 0.84 (0.55–1.28), 0.72 (0.46–1.14), and 0.92 (0.37–2.28). These findings suggest a significant association of cerebral arteriolosclerosis with the presence, number, and location (cortical and subcortical) of microinfarcts, and a weak and non-significant association of CAA with each microinfarct, highlighting the need for future research to better understand the role of small vessel diseases in the pathogenesis of cerebral microinfarcts.
Renal Biomarkers and Novel Therapies in Pediatric Nephrology: From Chronic Kidney Disease to Renal Transplantation
Authors: Chirico Valeria , Chimenz Roberto
Published: June 2023

Chronic kidney disease (CKD), a growing problem with an estimated prevalence of 74 [...]
Predictors of Hangover Frequency and Severity: The Impact of Alcohol Consumption, Mental Resilience, Personality, Lifestyle, Coping and Mood
Authors: Verster Joris C. , Donders Julie A. , Boogaard Anne S. , Bruce Gillian
Published: June 2023

Mental resilience is the ability to bounce back from daily life stressors such as divorce or losing a job. Extensive research has demonstrated a negative relationship between mental resilience and alcohol consumption. That is, both the quantity and frequency of alcohol consumption are greater in individuals with lower levels of mental resilience. There has, however, been little scientific attention paid to the relationship between mental resilience and alcohol hangover severity. The objective of this study was to evaluate psychological factors that may impact the frequency and severity of alcohol hangovers, including alcohol intake itself, mental resilience, personality, baseline mood, lifestyle, and coping mechanisms. An online survey was conducted among Dutch adults (N = 153) who had a hangover after their heaviest drinking occasion in the period before the start of the COVID-19 pandemic (15 January to 14 March 2020). Questions were asked about their alcohol consumption and hangover severity on their heaviest drinking occasion. Mental resilience was assessed with the Brief Mental Resilience scale, personality with the Eysenck Personality Questionnaire–Revised Short Scale (EPQ-RSS), mood via single item assessments, and lifestyle and coping with the modified Fantastic Lifestyle Checklist. The partial correlation, corrected for estimated peak blood alcohol concentration (BAC), between mental resilience and hangover severity was not significant (r = 0.010, p = 0.848). Furthermore, no significant correlations were found between hangover severity or frequency and personality and baseline mood. For lifestyle and coping factors, a negative correlation was found between the use of tobacco and toxins (i.e., drugs, medicines, caffeine) and the frequency of experiencing hangovers. Regression analysis revealed that hangover severity after the heaviest drinking occasion (31.2%) was the best predictor of hangover frequency, and that subjective intoxication on the heaviest drinking occasion (38.4%) was the best predictor of next-day hangover severity. Mood, mental resilience, and personality were not relevant predictors of hangover frequency and severity. In conclusion, mental resilience, personality, and baseline mood do not predict hangover frequency and severity.
Limited Link of Common Blood Parameters with Tinnitus
Authors: Bulla Jan , Brueggemann Petra , Wrzosek Małgorzata , Klasing Sven , Boecking Benjamin , Basso Laura , Nyamaa Amarjargal , Psatha Stamatina , Rose Matthias , Mazurek Birgit
Published: June 2023

Background: Tinnitus severity is generally assessed by psychometric and audiological instruments. However, no objective measure exists to evaluate the subjective discomfort and suffering caused by this hearing phenomenon. The objective of this work was to determine the possible blood parameters for diagnostics and therapy. Methods: We measured tinnitus distress by using the Tinnitus Questionnaire (TQ) and collected tinnitus-related audiological measures, namely the hearing threshold (HT), tinnitus loudness (TL), and sensation level (SL, i.e., the tinnitus loudness/hearing threshold at a tinnitus frequency). Blood samples were taken from 200 outpatients of the Tinnitus Centre of the Charité, and 46 routine blood count parameters were examined. The possible interactions were determined by (robust) linear models. Results: Tinnitus distress and audiological measurements were largely uncorrelated but could partly be predicted by selected blood parameters. First, the erythrocyte counts predicted tinnitus distress to a small extent. Second, the levels of vitamin D3 explained about 6% of tinnitus loudness and, age-dependently, the hearing threshold variability. Last, the levels of uric acid explained about 5% of the sensation level variability. Conclusions: Tinnitus is a multidimensional phenomenon. The marginal influences of blood markers suggest the possible roles of inflammation and oxidative stress produced by psychological or somatic burdens. Clinically, a vitamin D substitution (in older patients) might have a hearing-protective effect.
Epidemiology, Translation and Clinical Research of Ophthalmology
Authors: Jin Kai , Shen Wenyue , Liang Yuanbo , He Mingguang
Published: June 2023

The human eye is a complex and vital organ that plays a significant role in maintaining a high quality of human life [...]
Radiological Factors Associated with Bisphosphonate Treatment Failure and Their Impact on Fracture Healing in Postmenopausal Women with Osteoporotic Vertebral Fractures
Authors: Kim Hong Jin , Chang Ha Kyun , Chang Dong-Gune , Ha JiYun , Keum Byeong-Rak , Kim Gun-Hwa
Published: June 2023

(1) Background: Bisphosphonate treatment failure is one of the most difficult clinical problems for patients with osteoporosis. This study aimed to analyze the incidence of bisphosphonate treatment failure, associated radiological factors, and effect of fracture healing in postmenopausal women with osteoporotic vertebral fractures (OVFs). (2) Methods: A total of 300 postmenopausal patients with OVFs who were prescribed bisphosphonate were retrospectively analyzed and divided into two groups according to the treatment response: response (n = 116) and non-response (n = 184) groups. The radiological factors and the morphological patterns of OVFs were included in this study. (3) Results: The initial BMD values of the spine and femur in the non-response group were significantly lower than those in the response group (all Ps < 0.001). The initial BMD value of the spine (odd ratio = 1.962) and the fracture risk assessment tool (FRAX) hip (odd ratio = 1.32) showed statistical significance in logistic regression analysis, respectively (all Ps < 0.001). (4) Conclusions: The bisphosphonate non-responder group showed a greater decrease in BMD over time than the responder group. The initial BMD value of the spine and the FRAX hip could be considered radiological factors influencing bisphosphonate non-response in the postmenopausal patients with OVFs. The failure of bisphosphonate treatment for osteoporosis has a possible negative on the fracture healing process in OVFs.
Can Dialysis Patients Identify and Diagnose Pulmonary Congestion Using Self-Lung Ultrasound?
Authors: Schneider Eyal , Maimon Netta , Hasidim Ariel , Shnaider Alla , Migliozzi Gabrielle , Haviv Yosef S. , Halpern Dor , Abu Ganem Basel , Fuchs Lior
Published: June 2023

Background: With the recent developments in automated tools, smaller and cheaper machines for lung ultrasound (LUS) are leading us toward the potential to conduct POCUS tele-guidance for the early detection of pulmonary congestion. This study aims to evaluate the feasibility and accuracy of a self-lung ultrasound study conducted by hemodialysis (HD) patients to detect pulmonary congestion, with and without artificial intelligence (AI)-based automatic tools. Methods: This prospective pilot study was conducted between November 2020 and September 2021. Nineteen chronic HD patients were enrolled in the Soroka University Medical Center (SUMC) Dialysis Clinic. First, we examined the patient’s ability to obtain a self-lung US. Then, we used interrater reliability (IRR) to compare the self-detection results reported by the patients to the observation of POCUS experts and an ultrasound (US) machine with an AI-based automatic B-line counting tool. All the videos were reviewed by a specialist blinded to the performer. We examined their agreement degree using the weighted Cohen’s kappa (Kw) index. Results: A total of 19 patients were included in our analysis. We found moderate to substantial agreement between the POCUS expert review and the automatic counting both when the patient performed the LUS (Kw = 0.49 [95% CI: 0.05–0.93]) and when the researcher performed it (Kw = 0.67 [95% CI: 0.67–0.67]). Patients were able to place the probe in the correct position and present a lung image well even weeks from the teaching session, but did not show good abilities in correctly saving or counting B-lines compared to an expert or an automatic counting tool. Conclusions: Our results suggest that LUS self-monitoring for pulmonary congestion can be a reliable option if the patient’s count is combined with an AI application for the B-line count. This study provides insight into the possibility of utilizing home US devices to detect pulmonary congestion, enabling patients to have a more active role in their health care.
Modes of Operation and Forcing in Oil Spill Modeling: State-of-Art, Deficiencies and Challenges
Authors: Keramea Panagiota , Kokkos Nikolaos , Zodiatis George , Sylaios Georgios
Published: June 2023

Oil spills may have devastating effects on marine ecosystems, public health, the economy, and coastal communities. As a consequence, scientific literature contains various up-to-date, advanced oil spill predictive models, capable of simulating the trajectory and evolution of an oil slick generated by the accidental release from ships, hydrocarbon production, or other activities. To predict in near real time oil spill transport and fate with increased reliability, these models are usually coupled operationally to synoptic meteorological, hydrodynamic, and wave models. The present study reviews the available different met-ocean forcings that have been used in oil-spill modeling, simulating hypothetical or real oil spill scenarios, worldwide. Seven state-of-the-art oil-spill models are critically examined in terms of the met-ocean data used as forcing inputs in the simulation of twenty-three case studies. The results illustrate that most oil spill models are coupled to different resolution, forecasting meteorological and hydrodynamic models, posing, however, limited consideration in the forecasted wave field (expressed as the significant wave height, the wave period, and the Stokes drift) that may affect oil transport, especially at the coastal areas. Moreover, the majority of oil spill models lack any linkage to the background biogeochemical conditions; hence, limited consideration is given to processes such as oil biodegradation, photo-oxidation, and sedimentation. Future advancements in oil-spill modeling should be directed towards the full operational coupling with high-resolution atmospheric, hydrodynamic, wave, and biogeochemical models, improving our understanding of the relative impact of each physical and oil weathering process.
Optimization of the Concentrated Inspection Campaign Model to Strengthen Port State Control
Authors: Lai Chiu-Yu , Liu Chung-Ping , Huang Kuo-Ming
Published: June 2023

The concentrated inspection campaign (CIC) is a derivative of the port state control (PSC) supplement, which is a fixed single series of deficiency inspections performed for three consecutive months at the end of each year. This study used grey relational analysis (GRA) and the technique for order preference by similarity to ideal solution (TOPSIS) to analyze the data of 71,376 deficiency records with 496 deficiency codes and 21 ship types in the Paris MoU for the last three years so as to improve the existing focus inspection pattern, which uses only the most accumulated number of deficiency series of the previous year’s PSC inspection. It also combines the three-sigma rule to find the inspection items most likely to be found as deficient by the port state control officer (PFSO) of the member country and creates a new rolling CIC scheme with deficiency inspection data for the last three years, which can filter out the significant deficiency codes with high numbers of deficiency inspections and use them as a modified CIC. It can not only solve the existing CIC’s lack of thoroughness, but also avoid the problems of missing important inspection codes, missing substandard ships, and failing to meet the inspection consensus. The new CIC inspection mechanism created in this paper can indeed identify potential substandard ships more effectively and fill the inspection gap of the existing port state control.
D-ROMs and PAT Tests Reveal a High Level of Oxidative Stress in Patients with Severe Well-Controlled Asthma, and D-ROMs Are Positively Correlated with R20 Values That Indicate Approximate Central Airway Resistance
Authors: Kotsiou Ourania S. , Tourlakopoulos Konstantinos , Kontopoulou Lamprini , Mavrovounis Georgios , Pantazopoulos Ioannis , Kirgou Paraskevi , Zarogiannis Sotirios G. , Daniil Zoe , Gourgoulianis Konstantinos I.
Published: June 2023

Background: The derivatives-reactive oxygen metabolites (d-ROMs) and plasma antioxidant capacity (PAT) tests are oxidative indexes. Severe asthma has been related to oxidative stress. We aimed to investigate d-ROMs and PAT values in severely controlled asthmatics and the correlation of these values with lung function. Methods: Blood samples were collected from severely controlled asthmatics and centrifuged at 3000 rpm for 10 min. The supernatant was collected. The assays were performed within three hours of collection. The fraction of exhaled nitric oxide (FeNO), impulse oscillometry (IOS), and spirometry were determined. Symptom control was recorded using the asthma control test (ACT). Results: Approximately 40 patients with severe controlled asthma (75%: women), mean age of 62 ± 12 years, were recruited. Approximately 5% had obstructive spirometry. The IOS revealed airway abnormalities even though the spirometric results were within the normal range, with it being more sensitive than spirometry. The D-ROMs and PAT test values were higher than normal, indicating oxidative stress in severe asthmatics with controlled asthma. D-ROMs were positively correlated with R20 values, indicating central airway resistance. Conclusions: The IOS technique revealed an otherwise hidden airway obstruction with spirometry. The D-ROMs and PAT tests revealed a high level of oxidative stress in severe controlled asthmatics. D-ROMs correlate with R20, indicating central airway resistance.
Enhancing Radiotherapy Workflow for Head and Neck Cancer with Artificial Intelligence: A Systematic Review
Authors: Franzese Ciro , Dei Damiano , Lambri Nicola , Teriaca Maria Ausilia , Badalamenti Marco , Crespi Leonardo , Tomatis Stefano , Loiacono Daniele , Mancosu Pietro , Scorsetti Marta
Published: June 2023

Background: Head and neck cancer (HNC) is characterized by complex-shaped tumors and numerous organs at risk (OARs), inducing challenging radiotherapy (RT) planning, optimization, and delivery. In this review, we provided a thorough description of the applications of artificial intelligence (AI) tools in the HNC RT process. Methods: The PubMed database was queried, and a total of 168 articles (2016–2022) were screened by a group of experts in radiation oncology. The group selected 62 articles, which were subdivided into three categories, representing the whole RT workflow: (i) target and OAR contouring, (ii) planning, and (iii) delivery. Results: The majority of the selected studies focused on the OARs segmentation process. Overall, the performance of AI models was evaluated using standard metrics, while limited research was found on how the introduction of AI could impact clinical outcomes. Additionally, papers usually lacked information about the confidence level associated with the predictions made by the AI models. Conclusions: AI represents a promising tool to automate the RT workflow for the complex field of HNC treatment. To ensure that the development of AI technologies in RT is effectively aligned with clinical needs, we suggest conducting future studies within interdisciplinary groups, including clinicians and computer scientists.
Temporal Patterns of Structural Sagebrush Connectivity from 1985 to 2020
Authors: Buchholtz Erin K. , O’Donnell Michael S. , Heinrichs Julie A. , Aldridge Cameron L.
Published: June 2023

The sagebrush biome within the western United States has been reshaped by disturbances, management, and changing environmental conditions. As a result, sagebrush cover and configuration have varied over space and time, influencing processes and species that rely on contiguous, connected sagebrush. Previous studies have documented changes in sagebrush cover, but we know little about how the connectivity of sagebrush has changed over time and across the sagebrush biome. We investigated temporal connectivity patterns for sagebrush using a time series (1985–2020) of fractional sagebrush cover and used an omnidirectional circuit algorithm to assess the density of connections among areas with abundant sagebrush. By comparing connectivity patterns over time, we found that most of the biome experienced moderate change; the amount and type of change varied spatially, indicating that areas differ in the trend direction and magnitude of change. Two different types of designated areas of conservation and management interest had relatively high proportions of stable, high-connectivity patterns over time and stable connectivity trends on average. These results provide ecological information on sagebrush connectivity persistence across spatial and temporal scales that can support targeted actions to address changing structural connectivity and to maintain functioning, connected ecosystems.
Learning Effects in Air Displacement Plethysmography
Authors: Muntean Paul , Popa Anca , Miclos-Balica Monica , Schick Falk , Munteanu Oana , Pupazan Vasile , Neagu Adrian , Neagu Monica
Published: June 2023

Air displacement plethysmography (ADP) is a widespread technique for assessing global obesity in both health and disease. The reliability of ADP has been demonstrated by studies focused on duplicate trials. The present study was purported to evaluate learning effects on the reliability of body composition assessment using the BOD POD system, the sole commercially available ADP instrument. To this end, quadruplicate trials were performed on a group of 105 subjects (51 women and 54 men). We estimated measurement error from pairs of consecutive trials—(1,2), (2,3), and (3,4)—to test the hypothesis that early measurements are subject to larger errors. Indeed, statistical analysis revealed that measures of reliability inferred from the first two trials were inferior to those computed for the other pairs of contiguous trials: for percent body fat (%BF), the standard error of measurement (SEM) was 1.04% for pair (1,2), 0.71% for pair (2,3), and 0.66% for pair (3,4); the two-way random effects model intraclass correlation coefficient (ICC) was 0.991 for pair (1,2), and 0.996 for pairs (2,3) and (3,4). Our findings suggest that, at least for novice subjects, the first ADP test should be regarded as a practice trial. When the remaining trials were pooled together, the reliability indices of single ADP tests were the following: ICC = 0.996, SEM = 0.70%, and minimum detectable change (MDC) = 1.93% for %BF, and ICC = 0.999, SEM = 0.49 kg, and MDC = 1.35 kg for fat-free mass (FFM). Thus, the present study pleads for eliminating learning effects to further increase the reliability of ADP.
Numerical Analysis of Low-Velocity Impact Behaviour of Protective Concrete-Filled Steel Plates Composite Wall
Authors: Xiao Hongmei , Yu Peng , Zhu Limeng , Zhang Chunwei , Hsiao Po-Chien
Published: June 2023

In this research, a protective concrete-filled steel plate composite wall (PSC) is developed, consisting of a core concrete-filled bilateral steel plate composite shear wall and two lateral replaceable surface steel plates with energy-absorbing layers. The PSC wall is characterised by high in-plane seismic performance as well as out-of-plane impact performance. Therefore, it could be employed primarily in high-rise constructions, civil defence initiatives, and buildings with stringent structural safety criteria. To investigate the out-of-plane low-velocity impact behaviour of the PSC wall, fine finite element models are validated and developed. Then, the influence of geometrical and dynamic loading parameters on its impact behaviour is investigated. The results show that the replaceable energy-absorbing layer could significantly decrease the out-of-plane displacement and plastic displacement of the PSC wall due to its large plastic deformation, which could absorb a significantly large amount of impact energy. Meanwhile, the PSC wall could maintain high in-plane seismic performance when subjected to impact load. The plastic yield-line theoretical model is proposed and utilised to predict the out-of-plane displacement of the PSC wall, and the calculated results agree very well with the simulated results.
Mechanical and Thermoanalytical Study of Polypropylene Geomats Exposed in the Field and the Laboratory
Authors: Lins da Silva Jefferson , Valentin Clever Aparecido , Kobelnik Marcelo , Pedroso Gabriel Orquizas Mattielo , Aparício-Ardila Maria Alejandra , Araújo Júnior Luiz Paulo Vieira de , Luz Marta Pereira da
Published: June 2023

A Hydroelectric Power Plant (HPP) presents erosion problems on reservoir slopes and margins. Geomats are a biotechnical composite technology increasingly used to protect soils against erosion. Survivability or durability of geomats is essential for successful application. This work analyses the degradation of geomats exposed in the field for more than six years. These geomats were used as erosion-control treatment in a slope at HPP Simplício in Brazil. The degradation of the geomats in the laboratory was also analysed through exposure in a UV ageing chamber for 500 h and 1000 h. Degradation was quantitatively evaluated by testing the tensile strength of the geomat wires and thermal tests such as thermogravimetry (TG) and differential scanning calorimetry (DSC). The results showed that the geomat wires exposed in the field had a greater decrease in resistance compared to the samples exposed in the laboratory. In the samples collected in the field, it could be observed that the degradation of the virgin sample occurred earlier than in the exposed samples, contrary to what was observed in the TG tests carried out with the samples exposed in the laboratory. The DSC analysis showed that the samples had similar behaviours for the melting peaks. This evaluation of the wires of the geomats was presented as an alternative to analysing the tensile strengths of discontinuous geosynthetic materials such as the geomats.
Feasibility and Efficacy of Morning Light Therapy for Adults with Insomnia: A Pilot, Randomized, Open-Label, Two-Arm Study
Authors: Yoon Jihyun , Heo Seokjae , Lee Hyangkyu , Sul Eungyeong , Han Taehwa , Kwon Yu-Jin
Published: June 2023

Background and Objectives: Light therapy (LT) is used as an adjunctive treatment for sleep problems. This study evaluates the impact of LT on sleep quality and sleep-related parameters in patients with sleep disorders. Materials and Methods: We performed a pilot, randomized, open-label clinical trial. Fourteen patients aged 20–60 years with insomnia were randomized into the control and LT groups (1:1 ratio). The LT group was instructed to use a device that provides bright LT (6000 K, 380 lux, wavelength 480 nm) for at least 25 min before 09:00 a.m. for two weeks. A self-reported questionnaire was used to evaluate circadian preference, mood, and sleep-related parameters. We analyzed serum cortisol levels and clock genes’ expression. Results: The Epworth Sleepiness Scale (ESS), insomnia severity index(ISI), and Pittsburgh Sleep Quality index(PSQI) were significantly improved within the LT group only after the two-week period. When comparing the two groups, only the change in ESS was significant (mean difference, control: −0.14 vs. LT: −1.43, p = 0.021) after adjusting for the baseline characteristics. There were no significant differences in serum cortisol or clock genes’ expression. Conclusions: LT can improve daytime sleepiness in patients with sleep disorders; however, further well-designed studies are warranted to confirm its efficacy.
Common Practice in the Treatment of Superficial Vein Thrombosis Involving the Sapheno-Femoral Junction: Results from a National Survey of the Italian Society of Angiology and Vascular Medicine (SIAPAV)
Authors: Camporese Giuseppe , Di Micco Pierpaolo , Di Nisio Marcello , Ageno Walter , Martini Romeo , Prandoni Paolo
Published: June 2023

Background and Objectives: Prophylactic doses of low-molecular-weight heparins or fondaparinux showed their efficacy and safety for treatment of all superficial vein thrombosis (SVT) of the lower limbs, yet not for those extended to the last 3 cm of the great saphenous vein, close to the sapheno-femoral junction, or considered as a deep-vein thrombosis. Some experts suggest that these patients should be managed with full anticoagulant doses but evidence to support this recommendation is lacking, suggesting the need for a properly designed trial. Materials and Methods: Before starting a new trial, the Italian Society of Angiology and Vascular Medicine (SIAPAV) decided to verify the common therapeutic approaches for patients with an SVT in Italian vascular centers based on a hypothetical significant variation in each daily clinical practice. A standardized questionnaire of 10 questions was administered to all SIAPAV affiliates by means of the official Society website. Results: From 1 December 2022 to 20 January 2023 a total of 191 members (31.8%) answered the questionnaire, showing a detailed and a substantial heterogeneity in the therapeutic approach to SVT patients among experienced vascular physicians and angiologists. Detailed results are reported in the relative section. Conclusions: The therapeutic approach of SVT extended to the iuxta-femoral segment of the great saphenous vein is still a matter of debate, and data to support therapeutic strategies are lacking. The wide heterogeneity in the management of SVT patients, including those with more extended thrombosis, confirmed that a randomized controlled clinical trial investigating the efficacy and the safety of a tailored therapeutic regimen in this particular subgroup of patients is strongly warranted.
Polymeric Based Hydrogel Membranes for Biomedical Applications
Authors: Trombino Sonia , Sole Roberta , Curcio Federica , Cassano Roberta
Published: June 2023

The development of biomedical applications is a transdisciplinary field that in recent years has involved researchers from chemistry, pharmacy, medicine, biology, biophysics, and biomechanical engineering. The fabrication of biomedical devices requires the use of biocompatible materials that do not damage living tissues and have some biomechanical characteristics. The use of polymeric membranes, as materials meeting the above-mentioned requirements, has become increasingly popular in recent years, with outstanding results in tissue engineering, for regeneration and replenishment of tissues constituting internal organs, in wound healing dressings, and in the realization of systems for diagnosis and therapy, through the controlled release of active substances. The biomedical application of hydrogel membranes has had little uptake in the past due to the toxicity of cross-linking agents and to the existing limitations regarding gelation under physiological conditions, but now it is proving to be a very promising field This review presents the important technological innovations that the use of membrane hydrogels has promoted, enabling the resolution of recurrent clinical problems, such as post-transplant rejection crises, haemorrhagic crises due to the adhesion of proteins, bacteria, and platelets on biomedical devices in contact with blood, and poor compliance of patients undergoing long-term drug therapies.
Integration of Porous Nanomaterial-Infused Membrane in UF/FO Membrane Hybrid for Simulated Osmosis Membrane Bioreactor (OsMBR) Process
Authors: Zahedipoor Ahmadreza , Faramarzi Mehdi , Mansourizadeh Amir , Ghaedi Abdolmohammad , Emadzadeh Daryoush
Published: June 2023

This study explored the use of a combination of hydrothermal and sol–gel methods to produce porous titanium dioxide (PTi) powder with a high specific surface area of 112.84 m2/g. The PTi powder was utilized as a filler in the fabrication of ultrafiltration nanocomposite membranes using polysulfone (PSf) as the polymer. The synthesized nanoparticles and membranes were analyzed using various techniques, including BET, TEM, XRD, AFM, FESEM, FTIR, and contact angle measurements. The membrane’s performance and antifouling properties were also assessed using bovine serum albumin (BSA) as a simulated wastewater feed solution. Furthermore, the ultrafiltration membranes were tested in the forward osmosis (FO) system using a 0.6-weight-percent solution of poly (sodium 4-styrene sulfonate) as the osmosis solution to evaluate the osmosis membrane bioreactor (OsMBR) process. The results revealed that the incorporation of PTi nanoparticles into the polymer matrix enhanced the hydrophilicity and surface energy of the membrane, resulting in better performance. The optimized membrane containing 1% PTi displayed a water flux of 31.5 L/m2h, compared to the neat membrane water value of 13.7 L/m2h. The membrane also demonstrated excellent antifouling properties, with a flux recovery of 96%. These results highlight the potential of the PTi-infused membrane as a simulated osmosis membrane bioreactor (OsMBR) for wastewater treatment applications.
Experimental and Numerical Analysis of a Pd–Ag Membrane Unit for Hydrogen Isotope Recovery in a Solid Blanket
Authors: Narcisi Vincenzo , Tamborrini Luca , Farina Luca , Cortese Gessica , Romanelli Francesco , Santucci Alessia
Published: June 2023

The interest of the fusion community in Pd–Ag membranes has grown in the last decades due to the high value of hydrogen permeability and the possibility of continuous operation, making it a promising technology when a gaseous stream of hydrogen isotopes must be recovered and separated from other impurities. This is the case of the Tritium Conditioning System (TCS) of the European fusion power plant demonstrator, called DEMO. This paper presents an experimental and numerical activity aimed at (i) assessing the Pd–Ag permeator performance under TCS-relevant conditions, (ii) validating a numerical tool for scale-up purposes, and (iii) carrying out a preliminary design of a TCS based on Pd–Ag membranes. Experiments were performed by feeding the membrane with a He–H2 gas mixture in a specific feed flow rate ranging from 85.4 to 427.2 mol h−1 m−2. A satisfactory agreement between experiments and simulations was obtained over a wide range of compositions, showing a root mean squared relative error of 2.3%. The experiments also recognized the Pd–Ag permeator as a promising technology for the DEMO TCS under the identified conditions. The scale-up procedure ended with a preliminary sizing of the system, relying on multi-tube permeators with an overall number ranging between 150 and 80 membranes in lengths of 500 and 1000 mm each.
Phase Transformation Behaviors and Dislocation Evolutions of an Additively Manufactured Ti-6Al-4V Alloy under Annealing Treatment
Authors: Ji Xiankun , Xie Haiming , Su Jinlong , Jiang Fulin , Teng Jie , Zhang Hui , Guo Baoqi
Published: June 2023

Post annealing treatment is generally needed for additively manufactured titanium alloy to decompose metastable phases, alleviate residual stress, and improve ductility. In this work, in-situ electrical resistivity and line profile analysis of X-ray diffraction were utilized for monitoring phase transformation behaviors and dislocation evolutions of a laser powder bed fusion-built Ti-6Al-4V alloy under post annealing treatment. Besides, hardness and tensile tests were adopted for revealing the effects of phase transformation and dislocation evolutions on the mechanical properties. The results indicated that post annealing treatment decomposed martensitic α′ into lamellar α + β and eliminated dislocations efficiently. The martensite decomposition rate increased with the annealing temperature. Annealing at 700 °C for 4 h eliminated 98% of the dislocations, and further annealing has only a limited influence on the dislocation density. Annealing at 700 °C for 16 h is beneficial for achieving a high ductility of 10.3% owing to the favorable equilibrium lamellar α + β microstructure. These findings provide valuable insights for optimizing post annealing treatment procedures to enhance the mechanical properties of additively manufactured Ti-6Al-4V alloys.
Influence of Tungsten Addition on Microstructure and Tensile Properties of Ti6Al4V Fabricated by Laser-Directed Energy Deposition
Authors: Li Junguo , Xiong Jinding , Sun Yi , Wei Qinqin
Published: June 2023

The addition of tungsten can improve the high-temperature oxidation resistance of titanium alloys. However, as its applications continue to expand, new demands are being placed on its room temperature strength. Here, we provide a dense titanium alloy with high strength by introducing proper W powders into the Ti6Al4V powders under direct energy deposition. The effect of tungsten addition on the microstructure and tensile properties of the Ti6Al4V alloy was investigated. Compared to pure Ti6Al4V, the titanium alloy with tungsten addition exhibited refined α′ martensite and β grains, which is attributable to the effect of tungsten on the structural subcooling of titanium and on the formation temperature of the α′ martensite. Owing to the synergistic strengthening effects of grain refinement and solid solution strengthening, the W-containing alloy shows a high tensile strength of 1333 MPa and yield strength of 1219 MPa, which are significantly higher than Ti6Al4V alloy’s tensile strength of 940 MPa and yield strength of 860 MPa. This approach provides a pathway for design and preparation of high-strength titanium alloys by additive manufacturing.
Electron-Beam Welding of Titanium and Ti6Al4V Alloy
Authors: Kotlarski Georgi , Kaisheva Darina , Ormanova Maria , Stoyanov Borislav , Dunchev Vladimir , Anchev Angel , Valkov Stefan
Published: June 2023

This work presents the results of the electron-beam welding of commercially pure α-Ti (CP-Ti) and Ti6Al4V (Ti64) alloys. The structure and mechanical properties of the formed welded joints were examined as a function of the power of the electron beam. The beam power was set to P1 = 2100 W, P2 = 1500 W, and P3 = 900 W, respectively. X-ray diffraction (XRD) experiments were performed in order to investigate the phase composition of the fabricated welded joints. The microstructure was examined by both optical microscopy, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDX). The mechanical properties of the formed joints were studied using tensile test experiments and microhardness experiments. The results of the experiments were discussed concerning the influence of the beam power on the microstructure and the mechanical properties of the weld joints. Furthermore, the practical applicability of the present method for the welding of α-Ti and Ti64 was also discussed.
Hot Ductility, Homogeneity of the Composition, Structure, and Properties of High-Strength Microalloyed Steels: A Critical Review
Authors: Zaitsev Alexander , Arutyunyan Nataliya , Koldaev Anton
Published: June 2023

High-strength microalloyed steels are widely used in various branches of technology and industry due to the simultaneous combination of high indicators of strength, ductility, fatigue, corrosion resistance, and other service properties. This is achieved due to the reasonable choice of the optimal chemical composition and parameters of temperature-deformation treatment of steel that provide a synergistic effect on the dispersed microstructure and characteristics of excess phase precipitates, which control the achievement of these difficult-to-combine properties of rolled products. Additionally, the improvement of the level and stability of these properties, as well as the prevention of the occurrence of defects, is largely determined by the indicators of the homogeneity of the composition, structure by volume and manufacturability of the metal, and primarily hot ductility, which are controlled by the presence of precipitation of excess phases, including microalloying elements. In accordance with the circumstances noted, in the present review, a generalization, systematization, and analysis of the results of the studies are conducted on the effect of phase precipitates on the hot ductility and homogeneity of composition and structure, depending on the chemical composition and parameters of the temperature-deformation treatment of steel.
Correlation between Mechanical Properties—Structural Characteristics and Cavitation Resistance of Rolled Aluminum Alloy Type 5083
Authors: Istrate Dionisie , Bordeasu Ilare , Ghiban Brândușa , Istrate Bogdan , Sbarcea Beatrice-Gabriela , Ghera Cristian , Luca Alexandru Nicolae , Odagiu Petrisor Ovidiu , Florea Bogdan , Gubencu Dinu
Published: June 2023

The 5000 series aluminum alloy 5083 is distinguished by excellent processability, excellent welding characteristics, and a strong resilience to corrosion, particularly in maritime environments. It is employed in the manufacture of ships, automobiles, spacecraft, and industrial buildings. The goal of the current study is to determine whether there is any relationship between the mechanical properties, structural characteristics, and cavitation erosion properties of aluminum alloy 5083 in the H111 state (rolled from 454 °C to 399 °C and annealed at 343 °C by holding in cooled air), followed by artificial ageing at (180 °C) with three maintenance periods of 1 h, 12 h, and 24 h, and at (140 °C) with three maintenance periods of 1 h, 12 h, and 24 h. The cavitation resistance experiments of the experimental samples were performed in accordance with ASTM G32-2016. The resistance to cavitation erosion was determined by making mean erosion penetration rate (MDER) or mean depth of erosion (MDE) analytical diagrams according to the duration of the cavitation attack and by measuring the maximum depth of cavitation erosion in the samples analyzed by stereomicroscopy and scanning electron microscopy. Finally, a structural correlation between the condition of the artificially aged laminate alloy and its resistance to cavitation erosion could be achieved: ageing at 180 °C, maintained for 24 h, could lead to a maximum depth of cavitation erosion MDEmax of about 5 µm.