bluuebunny/crossref_metadata_2025 huggingface dataset:
Description of a new species of the genus Morimospasma Ganglbauer, 1889 (Coleoptera: Cerambycidae, Lamiinae) from Hubei, Central China
Authors:   Institute of Entomology, College of Agriculture, Yangtze University, Jingzhou, Hubei 434025, P. R. China, Zhang J.H. ,   Hubei Engineering Research Center for Pest Forewarning and Management, Yangtze University, Jingzhou, Hubei, 434025, P. R. China, Wang P. ,   Institute of Entomology, College of Agriculture, Yangtze University, Jingzhou, Hubei 434025, P. R. China,   Hubei Engineering Research Center for Pest Forewarning and Management, Yangtze University, Jingzhou, Hubei, 434025, P. R. China, Xie G.L. ,   Institute of Entomology, College of Agriculture, Yangtze University, Jingzhou, Hubei 434025, P. R. China,   Hubei Engineering Research Center for Pest Forewarning and Management, Yangtze University, Jingzhou, Hubei, 434025, P. R. China,   Yangtze University College of Arts and Science, Jingzhou, Hubei, 434025, P. R. China, Wang W.K. ,   Institute of Entomology, College of Agriculture, Yangtze University, Jingzhou, Hubei 434025, P. R. China,   Hubei Engineering Research Center for Pest Forewarning and Management, Yangtze University, Jingzhou, Hubei, 434025, P. R. China
Published: January 2023

Morimospasma (Parvopama) shennongjiaensis sp. n. from Shennongjia Forestry District, Hubei, China is described and illustrated. New species is similar to M. (P.) granulatum Chiang, 1981 but differs from latter by color of body, slightly narrower elytra, and straight metafemora. The holotype of new species is deposited in the Entomological Museum, Yangtze University, Jingzhou, Hubei, China.
Two new species of Neuratelia Rondani (Diptera: Mycetophilidae) from Chukotka, North-East Russia
Authors:   Forest Research Institute of Karelian Research Centre of the Russian Academy of Sciences, Pushkinskaya str. 11, 185910, Petrozavodsk, Russia, Polevoi A.V.
Published: January 2023

Two new species of the fungus gnats genus Neuratelia Rondani, namely Neuratelia aculeata sp. n. and Neuratelia cornuta sp. n. are described and illustrated from the Anadyr River valley (Chukotka, North-East Russia). By structure of male terminalia Neuratelia aculeata sp. n. resembles Neuratelia nemoralis (Meigen, 1818), while Neuratelia cornuta sp. n. is noticeably different from all known Palaearctic and Nearctic species.
A pilot study on effect of intravenous iron sucrose on oxidative stress and antioxidant status of pregnant women with iron deficiency anemia
Authors: Rameshkumar Sanjana , Viswanathan Sathiyapriya , Jagadeesan Anusha Raja , Dhanunjaya Yallakanti
Published: January 2023

Objectives:

Iron deficiency anemia (IDA) is the most common nutritional deficiency among pregnant women in India. Iron can be supplemented orally or intravenously to treat IDA. Intravenous supplementation of iron can be risky as there is more possibility for the production of free iron in circulation. The role of free iron in the generation of free radicals and thereby oxidative stress is well known. The present study tends to evaluate oxidative stress and antioxidant status of intravenous iron sucrose treated pregnant women.

Materials and Methods:

This prospective study was conducted in ACS Medical College and Hospital, Chennai. Twenty pregnant women with moderate IDA (Hb: 7–9.9 g/dl) were included in the present study. Blood samples were collected before and after the treatment with intravenous iron sucrose to measure antioxidants such as reduced glutathione, catalase and superoxide dismutase, and lipid peroxidation marker such as malondialdehyde.

Results:

In the present study, plasma malondialdehyde levels were increased significantly after the treatment with intravenous iron sucrose. No significant alterations were observed in the levels of reduced glutathione and activities of catalase and superoxide dismutase.

Conclusion:

In the present study, intravenous iron sucrose infusion was associated with oxidative stress as evidenced by increased lipid peroxidation in antenatal women with IDA. Hence, treatment with antioxidants during iron infusions can be considered.
Calvarial tuberculosis – A report of seven cases from a tertiary care hospital
Authors: Rengarajan Santhanam , Krishnasamy Lakshmi
Published: January 2023

Tuberculosis primarily affecting the calvarium is one of the rare diseases which is on the rise in the past few decades. This disease has been rarely reported in the literature even from endemic regions. We report seven patients diagnosed with calvarial tuberculosis. All cases had histological features of tuberculosis and were mantoux positive. All were negative for AFB smears. Two out of four cases tested for TB GeneXpert were positive. The clinical presentations, radiological features and the management of the cases are discussed. Early diagnosis with high index of suspicion and awareness about the features of calvarial tuberculosis would help in proper management of the condition.
A review on the pharmacological potential of Indian spices in polycystic ovarian syndrome
Authors: Sharma Neelam , Kumar Vishal , Langeh Urvashi , Singh Charan , Singh Arti
Published: January 2023

Pharmacological Significance:

India has a distinct position in history for using spices from cooking to prevent and cure a variety of illnesses. Numerous studies have been conducted to evaluate the potential of these spices for a variety of conditions such as diabetes, metabolic syndrome, and polycystic ovarian syndrome (PCOS). PCOS is a condition in which women of reproductive age experience common health difficulties such as genetic, metabolic, and endocrine abnormalities. Notably, this may be distinguished by symptoms such as hirsutism, acne, and obesity.

Aim:

In this review, we looked at numerous Indian spices that may help to manage PCOS and its symptoms.

Materials and Methods:

All data were gathered from the literature using several databases such as PubMed and Europe PMC, publishers such as Springer, Wiley, Elsevier, and Taylor and Francis, and academic libraries such as Google scholar and Sci-Hub.

Results:

This study focuses on natural spices and their chemical constituents that have varied therapeutic effects such as anti-inflammatory, anti-oxidant, anti-androgenic, anti-estrogenic, anti-thrombolytic, and anti-diabetic for the treatment of PCOS in women.

Conclusion:

In this review, we looked at the effects of several Indian spices on the management of PCOS.
The Effect of Timing of Instillation Therapy on Outcomes and Costs for Patients Receiving Negative Pressure Wound Therapy
Authors: Collinsworth Ashley , Griffin Leah
Published: January 2023

Introduction. Although NPWTi-d has been associated with improved patient outcomes compared with NPWT alone, questions remain regarding the timing of NPWTi-d initiation. Objective. This study examined the effect of the timing of NPWTi-d initiation on patient outcomes and costs. Methods. A retrospective analysis was conducted utilizing a national, all-payer hospital database and included patients who received NPWTi-d in 2019. A matched cohort of 514 patients who received either early (within 1 day of NPWT application) or late (within 2–7 days of NPWT application) NPWTi-d initiation was created using propensity scoring. Differences in clinical outcomes and costs were compared using Wilcoxon rank sum, chi-square, and t tests. Results. Early NPWTi-d initiation was associated with significantly shorter NPWT duration (7.0 vs. 11.4 days; P <.0001) and inpatient stay (13.4 vs. 16.3 days; P <.0001) compared with late NPWTi-d initiation. Early NPWTi-d initiation was also associated with fewer debridements, OR visits during hospitalization, days until final OR procedure, and wound-related readmissions. Patients with early NPWTi-d initiation had a $10 877 lower mean cost of index admission (P <.0001), which included lower NPWT costs. Conclusion. Study data suggest that in these patients with wounds, early NPWTi-d initiation helped improve patient outcomes and reduced care costs.
Anti-Microbial Peptides from Medicinal Plants as an Alternative against Multi Drug Resistance
Authors:   Amity Institute of Biotechnology, Amity University Chhattisgarh, Raipur, Chhattisgarh 493225, India, A Singh , SDVN Pamidimarri ,   Discipline of Industrial Biotechnology, Gujrat Biotechnology University Gandhinagar, Gujarat, India, S Chauhan ,   Amity Institute of Biotechnology, Amity University Chhattisgarh, Raipur, Chhattisgarh 493225, India
Published: January 2023

From its discovery to today, antibiotics have revolutionized medicine, and various antibiotics have been studied, discovered and put to significant application and it continues to be helpful in controlling infections. Nonetheless over application of these antibiotics have given rise to Antibiotic Resistance (AR) and Multidrug Resistant pathogens (MDR) against the various antibiotic’s agents. Anti-microbial peptides are being explored as an alternative against the prevalent issue of MDR and AR. Anti-microbial peptides are the part of host’s first line of defense mechanism of innate immune response, are small peptides its molecular weight is 2-10kDa, it holds amphiphillic properties, and is usually positively charged at neutral pH value. The advantages posed by anti-microbial peptides are many like broad antimicrobial spectrum, rapid action, and lower risk of resistance, low toxicity and high selectivity. It poses many therapeutic like anti-cancerous, anti-inflammatory, anti-bacterial, anti-fungal, anti-viral, and immunomodulator properties as well. Plants are good source of antimicrobial peptides. A variety of applications can be achieved with plant derived antimicrobial peptides, including antibacterial, insecticide, and infection control, including the control of cellular infection by viruses. AMPs exist in different molecular forms like Cyclotides, cyclic cysteine knot, defensin, thionin, snakin- Like, hevein-like, knottin like peptides etc. It is expected that anti-microbial peptides will have a positive impact on medicine, food, industries as antifouling agents and agriculture. The major objective of this review articleis to explore and identify important antimicrobial peptides in medicinal plants like Ocimum sanctum and Santalum album.
Evaluating scalable supervised learning for synthesize-on-demand chemical libraries
Authors: Alnammi Moayad , Liu Shengchao , Ericksen Spencer S , Ananiev Gene E , Voter Andrew F , Guo Song , Keck James L , Hoffmann F Michael , Wildman Scott A , Gitter Anthony
Published: January 2023

Traditional small molecule drug discovery is a time consuming and costly endeavor. High-throughput chemical screening can only assess a tiny fraction of drug-like chemical space. The strong predictive power of modern machine learning methods for virtual chemical screening enables training models on known active and inactive compounds and extrapolating to much larger chemical libraries. However, there has been limited experimental validation of these models' extensibility toward practical applications on large commercially-available or synthesize-on-demand chemical libraries. Through a prospective evaluation with the bacterial protein-protein interaction PriA-SSB, we demonstrate that ligand-based virtual screening can identify many active compounds in a large commercial library. We use cross validation to compare different types of supervised learning models and select a random forest classifier as the best model for this target. When predicting the activity of more than 8 million compounds from Aldrich Market Select, the random forest substantially outperforms a naïve baseline based on chemical structure similarity. 48% of the random forest's 701 selected compounds are active. The random forest model easily scales to score one billion compounds from the synthesize-on-demand Enamine REAL database. We tested 68 chemically-diverse top predictions from Enamine REAL and observed 31 hits (46%), including one with an IC50 value of 1.3 µM.
Recent Developments of Porphyrin Photosensitizers in Photodynamic Therapy
Authors: A Alibasha , Ghosh Mihir
Published: January 2023

In the modern era, chemotherapy, radiation therapy, biomarker testing, immunotherapy, sonodynamic therapy, hormone therapy, photothermal therapy, photodynamic therapy, and many more therapies are available for cancer. Photodynamic therapy (PDT) is a potential, innovative and non-invasive way of treating cancer. The main component of PDT is photosensitizers (PS), role in the practical applications of PDT. When these PS are exposed to appropriate light or laser irradiation, they absorb the energy and enter an excited state. They eventually transmit the energy to the neighbouring molecules, generating reactive oxygen species (ROS), especially singlet oxygen (1O2) into the model animals and patients. The most used and popular sensitizers, such as photofrin, hematoporphyrin (Hp), aminolevulinic acid (ALA), Porphyrin, and its derivatives, were developed regularly from first-generation to third-generation PS. After the second-generation PS highly focused on Porphyrin and its derivatives with modification and complexation to boost the efficiency of PDT against cancer cells. This review focuses on the PDT development of porphyrins with nanoparticles as third-generation PS with selectivity, toxicity and biocompatibility. In addition, porphyrin-based nanomedicines are discussed in terms of current challenges and future prospects.
MESSI: a new method for stereochemical assignment of flexible and polyhydroxylated molecules inspired by wisdom of the crowd theory
Authors: Marcarino Maribel O. , Passaglia Lucas , Zanardi María Marta , Sarotti Ariel Marcelo
Published: January 2023

The use of quantum-based NMR methods to complement and guide the connectivity and stereochemical assignment of natural and unnatural products has grown enormously. One of the unsolved problems is related to the improper calculation of the conformational landscape of flexible molecules that have functional groups capable of generating a complex network of intramolecular H-bonding (IHB) interactions. Here we present MESSI (Multi-Ensemble Strategy for Structural Identification), a method inspired by the wisdom of the crowd theory that breaks with the traditional mono-ensemble approach. By including independent mappings of selected artificially manipulated ensembles, MESSI greatly improves the sense of the assignment by neutralizing potential energy biases.
Nurturing Creativity in the Visual Arts Classroom Understanding Teacher Strategies through Amabile's Componential Theory
Authors: Kukkonen Tiina , Bolden Benjamin
Published: January 2023

Creative skill-building is a major focus of educational systems around the world. In this article, we draw on data from four K-12 visual arts teachers to illustrate pedagogical strategies used to support students’ creative development. We adopt Teresa Amabile’s Componential Theory of Creativity to frame the teachers’ approaches to creative skill-building, identifying how they nurtured students’task motivation, domain-specific skills, and creativity-relevant processes. By presenting the teaching strategies in this way, we hope to enable art educators to recognize, shape, and enhance how their own teaching can support the development of student creativity in the visual arts classroom.
Orlando Ribeiro’s work on transhumant pastoralism in north-central Portugal: Guidelines for a research project on ethno-history and archaeology
Authors: Carvalho António Faustino , Tente Catarina
Published: January 2023

With very few exceptions, ethnographic data is hardly ever used as a framework for archaeological research in Portugal. However, the systematic work of Orlando Ribeiro (1911–1997) on the traditional forms of transhumant pastoralism in the north-central mountains of Portugal provides a unique ethno-historical framework for studying those practices in earlier times. Combining the abundant field observations and documentary analysis published by this geographer with ongoing archaeological and zooarchaeological research could shed great light on the long history of livestock management in the area. Some of the transhumance variables studied – ranges, itineraries, settlement locations, herd size, duration, community social organization and specific herding practices – serve as research guidelines for future projects. Due to unfavourable taphonomic conditions, zooarchaeological assemblages are scarce and poorly preserved in most of the territory, thus preventing any comprehensive reconstitution of past livestock compositions. This further enhances the importance of Ribeiro’s work.
Korelasi Moderasi Agama dengan Ajaran Manunggaling Kawula Gusti Syekh Siti Jenar
Authors: Ulviana
Published: January 2023

Dalam kehidupan sosial, manusia tidak luput dengan kelompok sosialnya, entah dalam sudut pandang budaya, agama, atau aliran-aliran tertentu yang ideologinya sama. Dari keberagaman tersebut, mereka membutuhkan kebijakan yang cocok untuk semua kalangan, seperti kebijakan Kementrian Agama RI yang menerapkan misi moderasi beragama. Berangkat dari pertanyaan, moderasi beragama yang bagaimanakah yang dimaksud Kementrian Agama RI?. Hal ini membuat konsep moderasi beragama yang dikolerasikan dengan konsep manunggaling kawulo Gusti Syekh Siti Jenar sangat penting sekali dalam kehidupan manusia. Karena hal itu menunjukkan bahwa nilai tasawuf dalam konsep manunggaling kawulo Gusti Syekh Siti Jenar akan ikut eksis dengan dunia moderasi beragama atau tidak. Penelitian ini termasuk penelitian kualitatif yang pengumpulan datanya dilakukan secara dokumentasi, kemudian menganalisis data dengan analisis isi. Data di dapat dari literatur yang relevan dengan ajaran manunggaling kawula Gusti Syekh Siti Jenar. Dari penelitian ini menyimpulkan moderasi beragama yang dicanangkan Kementrian Agama RI sebenarnya tidak jauh berbeda dengan konsep manunggaling kawula Gusti dari Syekh Siti Jenar dilihat dari implementasi keduanya, terutama pada prinsip adil dan seimbang.
Correlation Between Saccadic Eye Movement, Activities of Daily Living, and Cognitive Function in Elderly Patients With Stroke
Authors:   The Korean Society of Cognitive Therapeutic Exercise, Hwang Do-Yeon
Published: January 2023

This study aimed to analyze the correlation between saccadic eye movement, activities of daily living, and cognitive function in elderly patients with stroke, that could help establish interventions in clinical settings.
This study included 32 elderly patients with stroke who were admitted to a medical center. The King-Devick test (K-D test), Korean version of the Modified Barthel Index (K-MBI), and Korean version of the Montreal Cognitive Assessment (MoCA-K) were used as evaluation tools. The correlation between evaluation scores was analyzed using Pearson’s correlation coefficient.
The correlations between the total scores of the K-D test, K-MBI, and MoCA-K were statistically significant (p<0.01).
In addition, the K-D test showed statistically significant correlations with personal hygiene, bathing, feeding, toilet, stair climbing, dressing, chair/bed transfer, ambulation, and wheelchair use in the K-MBI and visuospatial/executive, naming, delayed recall, and orientation in the MoCA-K.
This study showed a correlation between saccadic eye movement, activities of daily living, and cognitive function in elderly patients with stroke. In the future, such studies with larger sample would help to establish interventions in clinical settings.
Kualitas mikrob dan sel somatik dalam susu yang berasal dari peternakan sapi perah di lokasi dataran tinggi dan dataran rendah
Authors: Jannah Zahratul , Isdoni Isdoni , Komala Iyep , Pisestyani Herwin
Published: January 2023

Konsumen berhak mengonsumsi susu yang aman, sehat, utuh dan halal. Faktor yang memengaruhi produktivitas dan kualitas susu, di antaranya adalah ketinggian lokasi serta kondisi lingkungan di sekitar peternakan. Penelitian ini bertujuan menganalisis perbedaan kualitas mikrob dan jumlah sel somatik (JSS) susu dari peternakan yang berlokasi di dataran tinggi (Cijeruk, Bogor) dan peternakan yang berlokasi di dataran rendah (Pondok Ranggon, Jakarta Timur). Parameter yang diamati, ialah angka lempeng total (ALT) mikrob, jumlah Staphylococcus aureus, dan JSS. Pengujian mikrob menggunakan metode hitungan cawan dan penghitungan JSS menggunakan metode Breed. Data dianalisis secara statistik dengan uji Mann-Whitney U dan Chi-square. Hasil ALT mikrob, jumlah S. aureus, dan JSS dalam susu yang berasal dari peternakan Pondok Ranggon yang berlokasi di dataran rendah menunjukkan nilai yang lebih tinggi dibandingkan dengan susu yang berasal dari peternakan Cijeruk yang berlokasi di dataran tinggi. Rata-rata ALT mikrob, jumlah S. aureus, dan JSS dalam susu dari peternakan Cijeruk berturut-turut adalah 1,6×104 ± 1,5×104 CFU/mL; 1,3×103 ± 4,2×103 CFU/mL; dan 1.795.000  ± 1.838.791 sel/mL. Rata-rata ALT mikrob, jumlah S. aureus, dan JSS dalam susu yang berasal dari peternakan Pondok Ranggon berturut-turut adalah 3,5×105 ± 1,0×106 CFU/mL; 1,7×105 ± 6,3×104 CFU/mL; dan 3.032.222 ± 4.348.654 sel/mL. Penelitian ini menunjukkan terdapat hubungan yang signifikan antara lokasi peternakan dengan jumlah S. aureus dalam susu (P<0,05). Kesimpulan dari penelitian ini ialah status mikrob dan JSS dalam susu dipengaruhi oleh lokasi peternakan.
Hubungan teknik pemerahan dengan jumlah Escherichia coli pada susu segar dari peternakan sapi perah di KUD Kertajaya, Kabupaten Kediri, Jawa Timur
Authors: Rahadyan Raihan Alif , Tyasningsih Wiwiek , Puspitasari Yulianna , Permatasari Dian Ayu , Widjiati Widjiati
Published: January 2023

Kelompok bakteri coliform ialah kelompok bakteri yang digunakan sebagai indikator sanitasi makanan, salah satunya pada produk susu. Penelitian ini bertujuan mengkaji hubungan teknik pemerahan dengan jumlah Escherichia coli pada susu segar dibandingkan dengan batas cemaran bakteri yang ditetapkan oleh Badan Standardisasi Nasional. Rancangan penelitian ini ialah penelitian deskriptif. Sampel susu sapi segar diambil dari peternakan Lucky Farm dan beberapa peternakan sapi perah tradisional di wilayah KUD Kertajaya, Kabupaten Kediri, Jawa Timur. Penelitian ini menggunakan metode most probable number (MPN).  Hasil penelitian menunjukkan 11/15 (73,3%) sampel susu segar yang menggunakan teknik pemerahan konvensional memiliki cemaran bakteri E. coli yang melebihi batas maksimal yang ditetapkan oleh Badan Standardisasi Nasional (< 3 MPN/mL). Sebaliknya, semua 15/15 (100%) sampel susu segar dengan teknik pemerahan mesin menunjukkan negatif E. coli dan memenuhi syarat batas cemaran bakteri maksimum. Teknik pemerahan susu memengaruhi batas cemaran E. coli pada susu segar. Sampel susu yang diambil menggunakan teknik pemerahan mesin memiliki hasil yang lebih baik dengan nilai MPN < 3 MPN/mL dibandingkan dengan sampel yang diambil menggunakan teknik pemerahan konvensional.
Penyembuhan luka sayatan kulit menggunakan topikal balsamum peruvianum pascaoperasi infark miokardium pada babi domestik (Sus scrofa domestica)
Authors: Febryanto Agung , Rahmiati Dwi Utari , Wientarsih Ietje , Murtiningrum Fitria Senja , Iman Bintang Nurul , Noviana Deni , Gunanti Gunanti
Published: January 2023

Babi adalah hewan model ideal yang biasa digunakan untuk penelitian kesehatan dan penyakit pada manusia karena memiliki anatomi dan fisiologi yang serupa, salah satunya dalam hal persembuhan luka. Penelitian ini bertujuan mengetahui efektivitas pemberian balsamum peruvianum pada persembuhan luka sayatan setelah operasi infark miokardium pada babi domestik (Sus scrofa domestica). Penelitian menggunakan lima ekor babi berumur 4–5 bulan, tiga ekor berjenis kelamin jantan dan dua ekor betina. Sayatan dibuat di bagian lateral toraks, antara tulang rusuk ke-3–4, memanjang dari dorsal ke ventral, dengan menggunakan electrocauter. Luka dijahit menggunakan benang Monosyn® 4.0 dengan pola jahitan subkutikuler/intradermal, kemudian diberi iodine 10% dan balsamum peruvianum 10% di seluruh permukaan bagian luka dua kali sehari. Persembuhan diamati pada hari ke-1, 4, 7, 11, dan 14 dan diberi skor (skala: 1–4) pada pemeriksaan makroskopis pada setiap babi hingga hari ke-18. Hasil pengamatan menunjukkan perbedaan skor persembuhan yang signifikan pada hari ke-11 dan ke-18 jika dibandingkan dengan hari ke-1. Sediaan topikal balsamum peruvianum dapat digunakan dan efektif untuk persembuhan luka sayatan pada kulit setelah operasi infark miokardium pada babi.
Toksisitas akut infusa daun pepaya Calina jantan (Carica papaya L.) pada mencit betina
Authors: Nurma Sari  , Safika Safika , Hamdika Yendri Putra  , Andriyanto Andriyanto
Published: January 2023

Pepaya (Carica papaya L) merupakan salah satu tanaman yang berpotensi sebagai obat untuk beragam penyakit. Penelitian bertujuan menguji toksisitas akut ekstrak daun pepaya Calina (IPB 9) jantan pada mencit betina dengan menentukan nilai lethal dose 50 (LD50), mengamati pengaruhnya pada organ tubuh mencit, dan menghitung konsentrasi ekstrak yang paling efektif.  Penelitian menggunakan 20 ekor mencit galur DDY yang dibagi secara acak ke dalam 4 kelompok perlakuan, yaitu kelompok kontrol (pemberian akuades) dan kelompok perlakuan pemberian infusa daun pepaya Calina jantan masing-masing dengan dosis 5, 10, dan 15 g/kg BB secara per oral. Pengamatan dilakukan pada mortalitas, gejala klinis, respons fisiologis, bobot badan, dan bobot relatif organ. Nilai LD50 menunjukkan pemberian infusa daun pepaya Calina jantan pada mencit betina bersifat tidak toksik. Pemberian infusa daun pepaya Calina jantan sampai dengan dosis 15 g/kg BB tidak menimbulkan gejala klinis yang bersifat patologis, perubahan makroanatomi organ, atau kematian. Pemberian infusa tidak menunjukkan efek yang signifikan pada peningkatan atau penurunan bobot badan. Pemberian infusa daun pepaya Calina jantan dengan dosis 10 g/kg BB terbukti paling efektif dalam mempertahankan pertambahan bobot badan secara normal dan tidak bersifat toksik. Berdasarkan penelitian, pemberian infusa daun pepaya Calina jantan sampai dengan dosis 15 g/kg BB bersifat tidak toksik dan tidak memengaruhi organ tubuh mencit, dengan dosis efektif sebesar 10 g/kg BB.
Perlindungan Hukum Pekerja Migran Indonesia Yang Bekerja Sebagai Awak Kapal Perikanan (AKP) Asing
Authors: Hadi Adha Lalu
Published: January 2023

Dalam menjamin pemenuhan hak atas pekerjaan dan penghidupan yang layak bagi kemanusiaan setiap warga negara, telah dikeluarkan Undang-Undang Nomor 18 Tahun 2017 tentang Pelindungan Pekerja Migran Indonesia yang mengatur tata kelola baru dalam Penempatan dan Pelindungan Pekerja Migran Indonesia. Disebutkan dalam pasal 4 ayat 1 huruf (c) UU No 18 tahun 2017 pelaut awak kapal dan pelaut perikanan yang bekerja pada kapal asing atau kapal berbendera asing merupakan salah satu yang termasuk kategori Pekerja migran Indonesia. Perlindungan yang masih minim kepada warga Negara Indonesia (WNI) yang bekerja sebagai awak kapal perikanan (AKP) pada kapal perikanan berbendera asing, adalah menjadi kebijakan mutlak yang harus dilakukan oleh Pemerintah Indonesia saat ini. Upaya tersebut harus dilakukan, karena AKP menghadapi resiko pekerjaan yang besar saat berada di atas kapal perikanan, khususnya di luar negeri. Rekomendasi dalam penelitian ini adalah pertama perbaikan regulasi menjadi salah satu kunci untuk bisa memberikan perlindungan penuh kepada seluruh AKP yang aktif bekerja di kapal perikanan. Melalui regulasi, berbagai upaya perlindungan juga akan bisa diwujudkan oleh Pemerintah Indonesia. Kedua   kehadiran dan peran Negara sangat dibutuhkan dalam rangka memberikan rasa aman dan nyaman bagi warga negara Indonesia khususnya yang bekerja pada kapal  perikanan asing dan berbendera asing dengan menerbitkan regulasi  yang memiliki atau mengacu pada ketentuan beberapa konvensi Internasional sebagai standar pembuatan peraturan perundang-undangan yang berlaku nasional, seperti yang termuat dalam konvensi; IMO Cape Town Agreement (CTA) tahun 2012; Konvensi Internasional IMO tentang Pelatihan, Sertifikasi dan untuk Personil Kapal Penangkap Ikan (STCW-F) tahun 1995; Konvensi ILO tentang Pekerjaan dalam Penangkapan Ikan (C188) tahun 2007.
Exploring science pedagogy on the web 2.0/mobile border: Teachers’ views of a mobile wiki-based inquiry approach
Authors: Oon Pey Tee , Pegrum Mark , Stevenson Michael , Benson Spencer
Published: January 2023

This paper reports on teachers’ experiences of a 10-week, wiki-based, predominantly mobile science education intervention for secondary school students. It was designed to shift traditional pedagogical approaches towards more inquiry-based approaches by combining the strengths of wikis and mobile smart devices. The four participating Macau science teachers, with shared responsibility for 250 students, noted greater student engagement and reported some shifts towards more constructivist pedagogy and more active student learning. Evidence emerged of the value of personalization, collaboration, online feedback, and authentic learning, but the lack of mobile optimization of the wiki platform negatively impacted the degree of personalization, collaboration and authenticity. Lessons were learned about the need for educational technology interventions to carefully consider the intersection between software and hardware; the reasons for the recent decline of wikis as educational tools; and the ongoing educational value of web 2.0-style collaboration in our increasingly mobile era.
Reflections from planning and implementing a modelling task
Authors: Tekin Dede Ayse , Bukova Guzel Esra
Published: January 2023

The aim of this study is to investigate both the planning and implementation process of a modelling task by a middle school mathematics teacher. The participant of the study, which was conducted as a single case study, is a middle school mathematics teacher who have knowledge and experience in modelling. The data collecting tools of this study were the lesson plans of the teacher, the observation notes taken by the researchers during the implementation of the modelling task, the video records of the implementation, students’ solution papers and the voice records of the pre- and final-interview conducted with the teacher. Whole data were analyzed according to a framework for modelling implementations developed by the authors through descriptive analysis. The teacher planned his in-class implementation to consolidate the circle concept and revised an existing modelling task by developing appropriate materials for the task. He asked students to arrange their desks appropriate to group work, decided to enable students to evaluate both the implementation and their peers, and announced their students that they would present their group solution and evaluate each other at the end of the lesson. During the implementation, he first reminded prior knowledge about circle and then presented the materials. He shared instructions about group work in the context of sharing social norms and gave information about the peer assessment form, which the students filled at the end of the lesson. During the students were solving the task, he intervened about enabling self-assessment in the groups, considering realistic values and comparing mathematical results with the problem context. In addition, during the solution, he tried to establish socio-mathematical norms by making explanations. After the solution process ended, student groups presented their solution approaches and discussed different solutions by comparing each solutions. Peer assessment form and affective evaluation form regarding the implementation were filled by the students at the end of the implementation. This study contributed the literature regarding modelling implementations and presented a different view about teacher actions in planning and implementing a modelling task.
Exploring the relationship between tacit models and mathematical infinity through history
Authors: Díaz-Chang Tamara , Arredondo Elizabeth-H
Published: January 2023

In this article we address the historical and epistemological study of infinity as a mathematical concept, focusing on identifying difficulties, counter-intuitive ideas and paradoxes that constituted implicit, unconscious models faced by mathematicians at different times in history, representing obstacles in the rigorous formalization process of this mathematical concept. It is shown how the active and conscious questioning of these models led to a process of axiomatization of mathematical infinity, which was completed with the works of Cantor (1883) and Robinson (1974). The implemented methodology is supported by a qualitative and argumentative bibliographic research based on content analysis from a meta-ethnography. From this research, information is obtained about the unconscious mathematical structures students are confronted with and the conscious patterns of reasoning they must develop to overcome difficulties and obstacles that these models produce, and thus achieve an adequate understanding of mathematical infinity.
Approach of nano materials in pharmaceutical science
Authors: Sathoori Manasa  , Shyamala  , B. Shireesha
Published: January 2023

Recent technical advancements have provided proof that evolution in Nano technology and Nano science is the fundamental factor. Physics, chemistry, materials science, and other engineering sciences are all involved in the multidisciplinary field of Nano technology. Nearly all areas of science and technology are seeing significant use of Nano technology. The varieties of Nano particles, as well as their synthesis and characterization methods, were highlighted in this review study. Although various techniques and applications have been described over the previous years, we primarily focused on the general synthetic approaches and uses of Nano materials here in order to give the young researchers a general perspective.
Transformative Use under Test in Andy Warhol Foundation v. Goldsmith
Authors:   Korea Copyright Commission, Ryu Shiwon
Published: January 2023

We met only a few cases that assessed fair use over ten years since fair use clause were introduced to our copyright act. Therefore, a pile of U.S. fair use cases that have accumulated in the fields of art and technology can be good reference to interpreting our fair use clause. The concept of transformative use bears a significant role in fair use analysis of U.S. case law. The U.S. Supreme Court defines the transformative use as adding new purpose or character to the original works by changing its “expression, meaning or messages”, and accepted the fair use defense in Campbell and Google mainly based on its assessment that the the use was transformative in each case. The role of transformativeness is essential in realization of the purpose of fair use doctrine, i.e., flexibly responding to technological changes in order to provide “breathing room” for freedom of expression. There also exist concerns regarding this concept as increasing vagueness of fair use standards leading to declined predictability, as well as harming carefully designed balance between copyright protection and fair use. Conflicting interests were expressed in a recent case related to a portrait photograph work employed in appropriation art works, Andy Warhol Foundation v. Goldsmith. As the district court and the appellate court arrived at opposite conclusions showing different views on transformativeness of Andy Warhol’s works, the U.S. Supreme Court is to resolve issues regarding limits of transformative use. As reviewed in this article, it was timely and meaningful attempt that the appellate court sought for the balance of conflicting interests of copyright owners and users while paying attention to the relationship between derivative works and transformative use. However, the appellate court decision exposed some limitations in terms of compatibility with the Supreme Court’s standards and its logic of interpretation. The Supreme Court’s decision to be made would have great meaning in modern application of fair use clause, and bring about great impact in the creation of modern art and licensing business. Also, the issues being dealt with in this case bear significance in our own situation where Korean Supreme Court provides no specific standards on the application of our fair use clause which was imported from U.S. copyright law.
Teologi Migrasi dan Diakonia Transformatif: Sebuah Tawaran Berteologi Merespons Realitas Migrasi di Era Globalisasi
Authors: Sinaga Lamria
Published: January 2023

Abstract. This article seeks to explore an emerging Migration Theology to respond to the reality of global migration. Global migration indicates migrants often experience injustice, violence, exploitation, and human trafficking. Using qualitative research methods with a descriptive approach and literature study, this article concludes that transformative diaconia is recommended in responsding to the reality of global migration with three approaches, namely: increasing cooperation between institutions dealing with migrants, strengthening international diaconal institutions, and solidarity actions for migrants.Abstrak. Artikel ini bertujuan mengeksplorasi Teologi Migrasi dan relasinya dengan pembebasan dalam rangka merespons realita migrasi global. Migrasi global memperlihatkan, kaum migran acap kali mengalami ketidakadilan, kekerasan, eksploitasi, dan perdagangan manusia. Dengan menggunakan metode penelitian kualitatif dengan pendekatan deskriptif analisis dan kajian literatur, artikel ini menyimpulkan bahwa diakonia transformatif sebagai keniscayaan dalam merespons realitas migrasi global dengan tiga pendekatan, yaitu: peningkatan kerjasama antar lembaga yang menangani migran, penguatan lembaga diakonia internasional, dan aksi dukungan solidaritas kepada kaum migran.
Autoridad moral y disciplinamento social en las cofradías de Granada bajo el Antiguo Régimen
Authors: López-Guadalupe Muñoz Miguel Luis
Published: January 2023

A medias entre los hombres y Dios, las cofradías representan uno de esos poderes intermedios en la sociedad del Antiguo Régimen. Son entes auto-regulados, cuyas reglas les otorgan un estatus de oficialidad, pero a la vez responden a impulsos de la cultura popular. Por eso, los cargos directivos de las cofradías y hermandades adquieren una autoridad moral que los convierte en agentes de mediación hacia dentro en la búsqueda de la paz comunitaria y vecinal. Es una autoridad simbólica con alta carga de representación social, que puede inscribirse en las prácticas de disciplinamiento social nacidas desde abajo. Esa autoridad moral, en el contexto de corporaciones mutuales y festivas, se analiza a través de las reglas de ciertas hermandades de Granada en la Edad Moderna.
Evidencias de validez y confiabilidad del DigCompEdu CheckIn en docentes de una universidad privada peruana
Authors: Gallardo-Echenique Eliana , Tomás-Rojas Ambrosio , Bossio Jorge , Freundt-Thurne Úrsula
Published: January 2023

Introducción: Desde hace algunos años, se vienen desarrollando diversos marcos y herramientas de autoevaluación para describir las facetas de la competencia digital de los docentes, siendo uno de estos el DigCompEdu CheckIn. Este ha sido validado al inglés en Marruecos, al alemán en Alemania, y al español en España. El objetivo de este estudio consiste en validar el instrumento que fue elaborado en otro contexto, para que responda a la necesidad de medir la competencia digital de los docentes de una universidad privada en Lima, Perú, a partir de su autopercepción. Método: Se realizó un estudio instrumental para determinar las evidencias de validez y confiabilidad de la herramienta DigCompEdu CheckIn. La muestra estuvo constituida por 1218 docentes de diferentes áreas: Arte, Ciencias, Ciencias Sociales, Ciencias Jurídicas, Ingenierías y Arquitectura, Ciencias de la Salud, y Humanidades. Resultados: Los resultados señalan la reagrupación de las competencias digitales en una estructura de tres factores (F1, F2, F3) y 22 competencias, a diferencia de la estructura original compuesta de seis factores. Esta reducción de la estructura de las competencias no descarta la interacción entre las competencias generales, sino que la mantiene. Las tres competencias globales (Competencias de los estudiantes (F1); Competencias profesionales de los educadores (F2); Competencias pedagógicas de los educadores (F3) interactúan y se interrelacionan. Conclusiones: Los hallazgos evidencian que el DigCompEdu CheckIn es una herramienta válida y confiable entre los docentes. Es necesario realizar nuevos estudios que verifiquen la propuesta de tres factores del instrumento para el contexto peruano, así como su confiabilidad en nuevas poblaciones y contextos culturales.
Implementación de un modelo integrado de gestión académica con LMS en el sistema universitario
Authors: Wong-Fajardo Emma Margarita , Mendoza-Rodas Mery , Hernández-Vásquez Ronald , Saavedra-Sánchez Hugo
Published: January 2023

La calidad de la educación superior de un país es un pilar fundamental para su desarrollo; ello implica reestructurar y autoevaluar programas de estudios, así como sistematizar los procesos académicos. La Universidad Católica Santo Toribio de Mogrovejo, en respuesta a estos retos y a las normativas nacionales de calidad, el Sistema Nacional de Evaluación, Acreditación y Certificación de Calidad Educativa (SINEACE) y la Superintendencia Nacional de Educación Superior Universitaria (SUNEDU), incorporó mejoras en los procesos académicos con el uso de Tecnologías de la Información. La presente investigación muestra resultados de la experiencia de implementación de un modelo integrado de gestión académica con los Learning Management Systems (LMS) en un contexto universitario y se explican las diversas fases que conformaron esta propuesta. El estudio corresponde a una investigación tecnológica aplicada con enfoque cuantitativo, la muestra fue censal complementándose con la técnica focus group y la aplicación de entrevistas semiestructuradas. Los resultados más importantes indican que: La implementación del modelo integrado de las plataformas tecnológicas dentro del Campus Virtual (Sistema de Enseñanza-Aprendizaje, Sistema de Gestión Académica y Sistema de Gestión Curricular) e integración de los LMS permiten evidenciar los niveles de logro de las competencias del perfil de egreso y el despliegue del sistema integrado de gestión académica con LMS y brinda un significativo soporte a las actividades del proceso de enseñanza-aprendizaje en USAT.
Laboratorio Virtual de Electromagnetismo como estrategia didáctica utilizando el enfoque de aprendizaje situado en ingeniería
Authors: Castro-Gutiérrez Nereyda , Flores-Cruz Jesús Alberto , Acosta Magallanes Fermín
Published: January 2023

Los laboratorios virtuales (LV) han tenido un especial interés en los últimos años en que la educación inmersiva resulta atractiva para los estudiantes y complementa los procesos de enseñanza y aprendizaje en las instituciones de diversos niveles educativos. Aunque existen varios tipos de laboratorios virtuales utilizados en diversos niveles educativos, existen importantes retos para el diseño de estos como estrategia didáctica ad-hoc. Una de las principales dificultades en la aplicación de tecnología educativa es contar con entornos educativos virtuales especialmente dedicados a las áreas de ingeniería, que no sólo presenten prácticas interactivas donde se manipulen las animaciones, sino que fomenten el análisis metacognitivo de los estudiantes; para así construir un aprendizaje autónomo y reflexivo a través de enfoques educativos que acompañen la innovación educativa a través de las nuevas tecnologías. Este artículo presenta el diseño e implementación de un Laboratorio Virtual de Electromagnetismo (LVE) como estrategia didáctica bajo el enfoque de aprendizaje situado, aplicado a estudiantes universitarios de ingeniería de manera remota a través de versiones portátiles de la herramienta didáctica diseñada con Unity® en una universidad pública de México. En esta investigación se describe el contexto del caso de estudio, la metodología para identificar los criterios bajo el enfoque del modelo educativo de aprendizaje situado sugerido para el desarrollo del entorno virtual, las características del diseño a través del software de animación y la intervención educativa implementada en el nivel de educación superior. Finalmente, se realiza un análisis de los resultados obtenidos después de la aplicación del laboratorio mediante el estudio de la percepción de la comunidad universitaria a través de encuestas de salida.
Prophetic Communication: Islam as Knowledge Practice
Authors: Najmuddin Muhammad , Amri Muhammad , Aderus Andi
Published: January 2023

Prophetic Communication is briefly defined as 'Prophetic Communication' or 'Apostolic Communication'. Prophetic communication does not only mean "communication that imitates the 'prophet's ways of communicating'', or 'dakwah' or 'Islamic communication', but goes further than that, namely communication that seeks to imitate prophetic goals. so the writer uses two theoretical frameworks, firstly Kuntowijoyo's prophetic communication, as well as Harun Nasution's in Islamic books in terms of various aspects. This research is based on library research. The data collected consists of verses from the Qur'an and written materials that have been published in the form of books, journals, and magazines as well as from the internet which have direct and indirect links. with this research. This research was also carried out using descriptive-analytical research, namely by describing the form of civil society embodied by the prophet through an Islamic communication approach that adorns religious social life. The results of the study found that the Qur'an is substantially and principally very relevant to the content of prophetic communication, namely a). amar ma'ruf (humanization), such as getting used to cooperative behavior, increasing social welfare, strengthening brotherhood, and maintaining social solidarity, b). nahi munkar (liberation), such as egalitarian-based identity construction, poverty alleviation, child protection, and gender equality, c). al-iman billah (transcendence), such as strengthening the values of faith and piety, repentance as a purification of the soul, and internalizing morals.
PENGARUH PENGETAHUAN GENERASI Z, PERSEPSI, DAN FASILITAS TERHADAP PREFERENSI PADA BANK SYARIAH DENGAN SIKAP SEBAGAI VARIABEL INTERVENING
Authors: Jalal Abdul , Indra Ahmad Perdana
Published: January 2023

Penelitian ini bertujuan untuk menganalisa pengaruh pengetahuan generasi z, persepsi, dan fasilitas perbankan syariah terhadap preferensi pada bank syariah dengan sikap sebagai variabel intervening. Jenis penelitian ini adalah jenis kuantitatif. Sumber data dari penelitian ini merupakan data primer yang berasal dari sampel yaitu generasi z yang ada di Universitas Islam Negeri (UIN) Sumatera Utara yang beralamat di Jl. William Iskandar Ps. V, Medan Estate, Kec. Percut Sei Tuan, Kabupaten Deli Serdang, Sumatera Utara. Teknik Pengumpulan data dilakukan dengan menggunakan teknik non probability sampling terhadap 99 orang responden. Penelitian menggunakan metode analisis jalur. Hasil dari penelitian ini menjukkan bahwa 1) variabel pengetahuan berpengaruh terhadap variabel preferensi. 2) variabel persepsi berpengaruh terhadap preferensi, 3) variabel fasilitas tidak berpengaruh terhadap preferensi, 4) variabel pengetahuan tidak berpengaruh terhadap variabel sikap, 5) variabel persepsi berpengaruh terhadap sikap, 6) variabel fasilitas tidak berpengaruh terhadap variabel sikap, 7) variabel preferensi berpengaruh terhadap sikap, 8) variabel pengetahuan tidak berpengaruh terhadap sikap melalui preferensi, 9) variabel persepsi berpengaruh terhadap variabel sikap melalui variabel preferensi, 10) variabel fasilitas tidak berpengaruh terhadap sikap melalui variabel preferensi

Kata Kunci: Pengetahuan Generasi Z, Persepsi, Fasilitas,  Preferensi, dan Sikap.