bluuebunny/crossref_metadata_2025 huggingface dataset:
Middle Ordovician (middle Darriwilian) Archaeospicularia and Entactinaria (radiolarians) from the Table Cove Formation, Piccadilly Quarry, Newfoundland, Canada
Authors: Kachovich Sarah , Aitchison Jonathan C.
Published: March 2021

New, distinctive, well-preserved and previously undescribed constituents of a Middle Ordovician (middle Darriwilian, Dw2) radiolarian assemblage from the Table Cove Formation in Newfoundland are described. Three-dimensional X-ray micro-computed tomography (μ-CT) facilitates detailed examination of key specimens revealing hitherto unknown details of the internal morphologies of key lower Paleozoic taxonomic groups, among which a lack of knowledge has previously impeded resolution of higher taxonomic rankings.

Twenty-seven archaeospiculid and entactinarian taxa are described and illustrated including six new species: Westernbrookia polygonata n. sp., Neopalaeospiculum piccadilliensis n. sp., Ramuspiculum laxum n. sp. Spongentactinia nazarovi n. sp., Aspiculum irregulare n. sp., and Nyfrieslandia ramosissima n. sp. The investigation extends the known ranges of the species: Pararcheoentactinia reedae Won and Iams, 2002; Sphaeroentactinia robusta Won and Iams, 2015; Varispiculum ectospiculatum Won and Iams, 2015; and Svalbardospiculum multifurcatum (Won, Iams, and Reed, 2005), together with the genus Echidnina to the mid-Darriwilian.

UUID: http://zoobank.org/74826b7b-bb86-45d5-ad23-e6e65e0706df.
The rise to dominance of lanternfishes (Teleostei: Myctophidae) in the oceanic ecosystems: a paleontological perspective
Authors: Schwarzhans Werner , Carnevale Giorgio
Published: March 2021

Lanternfishes currently represent one of the dominant groups of mesopelagic fishes in terms of abundance, biomass, and diversity. Their otolith record dominates pelagic sediments below 200 m in dredges, especially during the entire Neogene. Here we provide an analysis of their diversity and rise to dominance primarily based on their otolith record. The earliest unambiguous fossil myctophids are known based on otoliths from the late Paleocene and early Eocene. During their early evolutionary history, myctophids were likely not adapted to a high oceanic lifestyle but occurred over shelf and upper-slope regions, where they were locally abundant during the middle Eocene. A distinct upscaling in otolith size is observed in the early Oligocene, which also marks their earliest occurrence in bathyal sediments. We interpret this transition to be related to the change from a halothermal deep-ocean circulation to a thermohaline regime and the associated cooling of the deep ocean and rearrangement of nutrient and silica supply. The early Oligocene myctophid size acme shows a remarkable congruence with diatom abundance, the main food resource for the zooplankton and thus for myctophids and whales. The warmer late Oligocene to early middle Miocene period was characterized by an increase in disparity of myctophids but with a reduction in their otolith sizes. A second and persisting secular pulse in myctophid diversity (particularly within the genus Diaphus) and increase in size begins with the “biogenic bloom” in the late Miocene, paralleled with diatom abundance and mysticete gigantism.
‘Here be revisionary metaphysics!’ A critique of a concern about process philosophy
Authors: Giladi Paul
Published: March 2021

In this paper, I argue that John Dupré and Daniel Nicholson's ‘process manifesto’ is ironically more sympathetic to descriptive metaphysics than to revisionary metaphysics. Focusing on their argument that any process philosophy automatically slides into Whiteheadian obscurantism if it does not just rest content with revealing the problematic features of ordinary language, I argue that their position occludes a logical space, one in which revisionary metaphysics is articulated without any Whiteheadian obscurantism and involves no dereliction of critical/revisionary orientation. I argue that key features of the respective critical social ontologies of Judith Butler and Talia Mae Bettcher occupy such a logical space.
THE YONEDA EXT AND ARBITRARY COPRODUCTS IN ABELIAN CATEGORIES
Authors: ARGUDÍN-MONROY ALEJANDRO
Published: March 2021

There are well-known identities involving the Ext bifunctor, coproducts, and products in AB4 abelian categories with enough projectives. Namely, for every such category \[\mathcal{A}\], given an object X and a set of objects \[{\{ {{\text{A}}_{\text{i}}}\} _{{\text{i}} \in {\text{I}}}}\], an isomorphism \[Ext_\mathcal{A}^{\text{n}}({ \oplus _{{\text{i}} \in {\text{I}}}}{{\text{A}}_{\text{i}}},{\text{X}}) \cong \prod\nolimits_{{\text{i}} \in {\text{I}}} {Ext_\mathcal{A}^{\text{n}}({{\text{A}}_{\text{i}}},{\text{X}})} \] can be built, where \[Ex{t^{\text{n}}}\] is the nth derived functor of the Hom functor. The goal of this paper is to show a similar isomorphism for the nth Yoneda Ext, which is a functor equivalent to \[Ex{t^{\text{n}}}\] that can be defined in more general contexts. The desired isomorphism is constructed explicitly by using colimits in AB4 abelian categories with not necessarily enough projectives nor injectives, extending a result by Colpi and Fuller in [8]. Furthermore, the isomorphisms constructed are used to characterize AB4 categories. A dual result is also stated.
Leveraging Liminality: The Border Town of Bao'an (Shenzhen) and the Origins of China's Reform and Opening
Authors: Zhou Taomo
Published: March 2021

Located immediately north of Hong Kong, Shenzhen is China's most successful special economic zone (SEZ). Commonly known as the “social laboratory” of reform and opening, Shenzhen was the foremost frontier for the People's Republic of China's adoption of market principles and entrance into the world economy in the late 1970s. This article looks at prototypes of the SEZ in Bao'an County, the precursor to Shenzhen during the Mao era (1949–76). Between 1949 and 1978, Bao'an was a liminal space where state endeavors to establish a socialist economy were challenged by capitalist influences from the adjacent British Crown colony of Hong Kong. To create an enclave of exception to socialism, Communist cadres in Bao'an promoted individualized, duty-free cross-border trade and informal foreign investment schemes as early as 1961. Although beholden to the inward-looking planned economy and stymied by radical leftist campaigns, these local improvisations formed the foundation for the SEZ—the hallmark of Deng Xiaoping's economic statecraft.
Helminths of the mallardAnas platyrhynchosLinnaeus, 1758 from Austria, with emphasis on the morphological variability ofPolymorphus minutusGoeze, 1782
Authors: Jirsa F. , Reier S. , Smales L.
Published: March 2021

The mallardAnas platyrhynchosis the most abundant water bird species in Austria, but there is no record of its helminth community. Therefore, this work aimed to close that gap by recording and analysing the parasite community of a large number of birds from Austria for the first time. A total of 60 specimens shot by hunters in autumn were examined for intestinal parasites. The following taxa were recovered (prevalence given in parentheses): Cestoda:Diorchissp. (31.7%) andFimbriarioides intermedia(1.7%); Acanthocephala:Filicollis anatis(5%),Polymorphus minutus(30%) and one cystacanth unidentified (1.7%); Trematoda:Apatemon gracilis(3.3%),Echinostoma grandis(6.7%),Echinostoma revolutum(6.7%) andNotocotylus attenuatus(23.3%); Nematoda:Porrocaecum crassum(1.7%) and one not identified (1.7%). The frequency distribution of parasites showed a typical pattern in which 39 birds (65%) were either not parasitized or were harbouring up to five worms, whereas more intense infestations occurred in a lesser number of hosts. Compared to other studies from central and eastern Europe, an extremely depauperate helminth community, particularly of the cestodes and nematodes, was found.Polymorphus minutuswas observed as having highly variable morphology and, therefore, molecular genetic characterization by DNA barcoding was carried out. Species identification was confirmed by comparing data with the reference cytochromecoxidase subunit 1 gene sequence fromP.minutusavailable in GenBank.
Sub-grid-scale effects in magnetised plasma turbulence
Authors: Teaca Bogdan , Gorbunov Evgeny A. , Told Daniel , Bañón Navarro Alejandro , Jenko Frank
Published: March 2021

In the present paper, we use a coarse-graining approach to investigate the nonlinear redistribution of free energy in both position and scale space for weakly collisional magnetised plasma turbulence. For this purpose, we use high-resolution numerical simulations of gyrokinetic (GK) turbulence that span the proton–electron range of scales, in a straight magnetic guide field geometry. Accounting for the averaged effect of the particles’ fast gyro-motion on the slow plasma fluctuations, the GK approximation captures the dominant energy redistribution mechanisms in strongly magnetised plasma turbulence. Here, the GK system is coarse grained with respect to a cut-off scale, separating in real space the contributions to the nonlinear interactions from the coarse-grid scales and the sub-grid scales (SGS). We concentrate on the analysis of nonlinear SGS effects. Not only does this allow us to investigate the flux of free energy across the scales, but also to now analyse its spatial density. We find that the net value of scale flux is an order of magnitude smaller than both the positive and negative flux density contributions. The dependence of the results on the filter type is also analysed. Moreover, we investigate the advection of energy in position space. This rather novel approach for GK turbulence can help in the development of SGS models that account for advective unstable structures for space and fusion plasmas, and with the analysis of the turbulent transport saturation.
Market-Oriented Policies on Care for Older People in Urban China: Examining the Experiment-Based Policy Implementation Process
Authors: ZHANG WENJING
Published: March 2021

The rapidly ageing population and increasing care needs provide the rationale for care systems progressively shaped by a growing market in a global context. In China the approach to policy making, which has been largely experimental, has involved market-oriented reforms since the 1980s. While marketisation processes have been well studied in various European care systems, very little is known about their implementation in the Chinese context. Based on qualitative interviews with local government officials and care providers in Shanghai, this article discusses the Chinese policy process in the field of care for older people and the barriers to effective implementation. It investigates the experiment-based marketisation policy process, the power hierarchy and the lines of accountability of the state in the care field. Multi-layered barriers are identified in the market-oriented policy process. These include (1) inherent bureaucratic obstacles at practice level: reluctance to exercise discretionary power, administrative inefficiency, incoherence of care schemes and poor inter-department communication; and (2) complexities and failures at policy-making level: the infeasibility of policies, underestimation of operational capacity and inadequate involvement of practice knowledge. These findings have implications for balancing the efficiency, effectiveness and sustainability of care policies in an era of public service austerity.
The Problem of Success and Failure in Public-private Innovation Partnerships
Authors: HAMMOND JONATHAN , BAILEY SIMON , GORE OZ , CHECKLAND KATH , DARLEY SARAH , MCDONALD RUTH , BLAKEMAN THOMAS
Published: March 2021

Public-Private Innovation Partnerships (PPIPs) are increasingly used as a tool for addressing ‘wicked’ public sector challenges. ‘Innovation’ is, however, frequently treated as a ‘magic’ concept: used unreflexively, taken to be axiomatically ‘good’, and left undefined within policy programmes. Using McConnell’s framework of policy success and failure and a case study of a multi-level PPIP in the English health service (NHS Test Beds), this paper critically explores the implications of the mobilisation of innovation in PPIP policy and practice. We highlight how the interplay between levels (macro/micro and policy maker/recipient) can shape both emerging policies and their prospects for success or failure. The paper contributes to an understanding of PPIP success and failure by extending McConnell’s framework to explore inter-level effects between policy and innovation project, and demonstrating how the success of PPIP policy cannot be understood without recognising the particular political effects of ‘innovation’ on formulation and implementation.
Music and misogyny: a content analysis of misogynistic, antifeminist forums
Authors: de Boise Sam
Published: March 2021

Research exploring the relationship between misogyny and music has been divided between those who argue that certain music causes, confirms or is a manifestation of misogyny. Yet this often takes for granted the link between certain genres (predominantly hip hop, rap and metal) and misogynistic 'messages'. Instead of asking what types of music might be misogynistic, this article instead asks how music is discussed amongst those who actively espouse misogynistic views. Through content analysis of 1173 posts, from 6 ‘misogynistic antifeminist movement’ (MAM) forums, it shows that whilst hip hop, rap and metal genres and artists are the most commonly mentioned, there is significant variation in terms of musical preferences and justifications. Whilst masculinist lyrics were the main reasons for music preferences, this study shows how MAM communities’ musical judgments are a confluence of sonic and extra-musical discourses which are shaped and amplified within these online communities.
The ambivalence of becoming a small business: Learning processes within an aspiring rock band
Authors: Malm Tobias
Published: March 2021

The process of becoming a rock musician strongly relates to the organisational form of the band (Bennett 1980; Green 2002; Behr 2010). At all levels of ambition and success, membership of a band provides the musician with a natural entry point for performing to an audience and forging a potential career (Smith 2013a). The ‘micro-organisational’ (Bennett 2001) development of a band, therefore, is an important career prerequisite for rock musicians (Behr 2015). However, the social and practical challenges of musicianship seem to be continuously underemphasised within the field of popular music studies (Cohen 1993; Kirschner 1998; Lashua 2017; Weston 2017; Kielich 2018). Therefore, in this article I will focus on an aspiring rock band's informal learning processes in becoming a small business together. The study provides insights into the educational and organisational aspects of band practices and contributes to the fields of popular music, education and organisation studies – fields that are converging in the emerging interdisciplinary research area of ‘organising music-making’ (Beech and Gilmore 2015).
Broadening research in gender and music practice
Authors: Werner Ann , Gadir Tami , De Boise Sam
Published: March 2021

This article builds on research about gender in music practice, concerned with skewed musical canons, ratios and quotas of gender representation, unfair treatment and power dynamics, and the exclusionary enmeshment with music technologies. The aim is to critically discuss what ‘gender’ is understood to be, how it has been studied and how gendered power has been challenged, in order to suggest new routes for research on gender and music practice. While we count ourselves among the scholars working in the field and critically investigate our own work as well as that of others, the article addresses some additional concerns to those of previous studies by examining how gender is ontologically constructed in these studies, how intersectional approaches can enrich analyses of gender in music practice and how the material dimensions of music practice can be actively addressed. The conclusions outline suggestions for broadening research in gender and music practice.
The Hebrew Web Communicative Development Inventory (MB-CDI): Lexical Development Growth Curves
Authors: GENDLER-SHALEV Hila , DROMI Esther
Published: March 2021

This article presents data on lexical development of 881 Israeli Hebrew-speaking monolingual toddlers ages 1;0 to 2;0. A Web-based version of the Hebrew MacArthur-Bates Communicative Development Inventories (H-MB-CDI) was used for data collection. Growth curves for expressive vocabulary, receptive vocabulary, actions and gestures were characterized. Developmental trajectories of toddlers with various demographic characteristics, such as education, income, religiosity level, birth order of the child, and child-care arrangements were compared. Results show that the lexical growth curves for Hebrew are comparable to those reported for other languages. Sex, birth order, and child-care arrangements were found to influence the size of lexicons. It is recommended that the trajectories presented here be used as norms for lexical growth among typical Hebrew-speaking toddlers in the second year of life.
Performing for Peace and Social Change in Africa's Great Lakes Region
Authors: LE LAY MAËLINE
Published: March 2021

International aid has influenced and, in part, shaped the artistic sector in Africa's Great Lakes region (DRC, Rwanda, Burundi) since the 1990s, a period marked by numerous conflicts and mass violence. Due to NGOs’ programmatic foci, artists performing for social change are increasingly compelled to focus on reconciliation and conflict resolution, generating political awareness and bringing about social change, healing and peacemaking. Through a comparative analysis of European and local productions on the genocide this article asks, how and why does an ‘NGO-style theatre’ develop a specific audience in the region? How have themes such as mass violence, inter-ethnic conflict and social cohesion become the main concerns of the territory's theatre? How do performances made and/or sponsored by NGOs challenge not only theatre's form, its social stakes and functions, but also the conception of its audience and the relationships between actors and spectators?
Associations of genetic variants at TAP1 and TAP2 with pulmonary tuberculosis risk among the Chinese population
Authors: Zhang Mingwu , Wang Xiaomeng , Zhu Yelei , Chen Songhua , Chen Bin , Liu Zhengwei
Published: March 2021

Tuberculosis (TB) is a common infectious disease, and the present study aims to explore the associations of single nucleotide polymorphisms (SNPs) at rs1135216 and rs1057141 of transporter-associated antigen processing (TAP1) and rs2228396 of TAP2 with pulmonary tuberculosis (PTB) risk. A case–control study including 168 smear-positive PTB cases and 251 controls was conducted. Genotyping of the SNPs at rs1135216, rs1057141 and rs2228396 was performed, and their associations with PTB risk were analysed with SPSS software version 19.0. After conducting stratification for age, a significant association was detected for rs1057141 with increased PTB risk (OR = 0.17, 95% CI 0.04–0.79) among those aged ≥60 years. For those aged <60 years, a marginally significant association was detected between rs1135216 TC/CC and PTB risk (OR = 1.97, 95% CI 0.93–4.19). Haplotype analysis revealed that the haplotype AT at rs1135216 and rs2228396, as well as AAT at rs1057141, rs1135216 and rs2228396, was associated with increased PTB risk, and the ORs were 2.83 (95% CI 1.30–6.14) and 2.89 (95% CI 1.34–6.27), respectively. Rs1057141 is a genetic predictor of reduced PTB risk for those aged ≥60 years, while rs1135216 might be a potential genetic predictor for those aged <60 years. Haplotype AT at rs1135216 and rs2228396, as well as AAT at rs1057141, rs1135216 and rs2228396, is a genetic marker that may predict PTB risk.
The decline and fall of an early modern slum: London's St Giles ‘Rookery’, c. 1550–1850
Authors: Crymble Adam
Published: March 2021

The Rookery of London's St Giles-in-the-Fields became the city's most notorious slum by the eighteenth century. This article asks why? Why there, why then and why for so long? Building on existing research about urban development and the failure of local government, by considering the geography, economics and legal influences acting upon the space and the people who interacted with it over the long durée, it becomes clear that the Rookery of St Giles-in-the-Fields was always high risk because of happenstance of geography, but that a lack of leadership from its owners and a system of urban upkeep that distributed responsibility too widely led to its longevity and the depth of its misfortune.
Becoming an older caregiver: A study of gender differences in family caregiving at the end of life
Authors: Spatuzzi Roberta , Giulietti Maria Velia , Romito Francesca , Reggiardo Giorgio , Genovese Carmela , Passarella Michele , Raucci Letizia , Ricciuti Marcello , Merico Fabiana , Rosati Gerardo , Attademo Luigi , Vespa Anna
Published: March 2021

Objectives

Older people are not traditionally expected to become caregivers. For this reason, the experience of caregiving in older persons has not been explored adequately in the research on gender differences. The objective of this study was to assess the caregiver burden among older family members who care for cancer patients facing the end of their lives, in order to compare their differences according to gender (male vs. female).

Methods

This is a cross-sectional study. A total of 102 older caregivers (aged ≥65 years) of hospice patients were interviewed through the Caregiver Burden Inventory (CBI). The sample group was divided into two gender subgroups.

Results

Compared with male caregivers, the older female group reported significantly higher scores in the CBI–physical subscale (P = 0.028), and in the CBI, the overall score (P = 0.0399) confirmed by the generalized linear model (multivariate) evaluation that included possible predictors in the model. There were no significant differences in the other CBI subscale scores (time-dependent, developmental, social, and emotional).

Significance of results

Older female caregivers are at higher risk of experiencing burden and worse physical health compared with men. Further research is needed in modern palliative care to assess the role of gender differences in the experience of caregiving when the caregiver is an older person.
Determinants of institutional trust: the role of cultural context
Authors: Kaasa Anneli , Andriani Luca
Published: March 2021

We examine the cultural context for individual's trust in public institutions. To shed some light on possible cultural explanations from a more comparative perspective and cover a wider set of cultural aspects, we use indicators of cultural dimensions by Kaasa et al. (2014) based on Hofstede's (1980) approach. Multilevel regression analysis is conducted with individual-level data from two waves of the European Social Survey (2008, 2010) and regional-level data from multiple sources. Confirmatory factor analysis is used to construct the indicators of social and institutional trust and corruption. Our results suggest that individuals tend to trust institutions less in regions with large power distance. Hence, an important key for governments being more successful in achieving their aims seems to be related to improving the sense of participation and civic responsibility.
Genetic and Environmental Influences on Vigorous Exercise in South Korean Adolescent and Young Adult Twins
Authors: Hur Yoon-Mi
Published: March 2021

Twin studies of physical exercise for Asian twins are sparse. This study aimed to examine genetic and environmental influences on frequency of vigorous exercise (FVE) in South Korean twins, with a special emphasis on sex effects. Telephone interviews on FVE were administered to 1757 twins (mean age = 19.05 years, SD = 3.01 years). Tetrachoric correlations were significantly different between monozygotic (MZ) and dizygotic (DZ) twins in males (.40 vs. .12), but they were similar in females (.44 vs. .45), suggesting the importance of genetic factors in FVE in males and that of common environmental factors in females. A scalar sex-limitation model incorporating age as a modifier was applied to data. The results revealed that genetic, common and individual environmental influences did not vary significantly with age, but differed across two sexes, confirming twin correlational analyses. In the best-fitting model, additive genetic and individual environmental influences on FVE were, respectively, .35 (95% CI [.26, .39]) and .65 (95% CI [.61, .74]) in males, and common and individual environmental influences were, respectively, .45 (95% CI [.35, .53]) and .55 (95% CI [.47, .65]) in females. These results contrasted starkly with recent findings from a large sample of Chinese adult twins (age >18 years), in which most variance (≥95%) of vigorous physical activity was attributable to common environmental influences in both sexes. Replications in other Asian samples are clearly needed.
Assessing the Effect of Riming on Snow Microphysics: The First Observational Study in East China
Authors: Zhang Yun , Zheng Hepeng , Zhang Lifeng , Huang Yanbin , Liu Xichuan , Wu Zuhang
Published: March 2021

Through the collision and freezing of supercooled droplets on the surface of snow particles, riming can change the density, fall velocity and aspect ratio of snow particles. Riming plays an important role in the formation of precipitation in cold clouds. To our knowledge, the impact of riming on snow microphysics is yet well understood, and there is a lack of observations obtained in China addressing this issue. For the first time in East China, the connection between riming and snow microphysical properties was investigated quantitatively during snow events in two winters. To quantify the degree of riming, the rime mass fraction (FR) is derived using the combination of a 2‐D video disdrometer (2DVD) and a weighing gauge. FR is added to the density‐diameter and fall velocity‐diameter relations, and a quantitative relation between riming and shapes of snowflakes is established based on the in situ observation of the 2DVD. The results show that riming can well explain the variability in the density and fall velocity of snowflakes. The changes in the shape of snowflakes can be divided into two distinct stages with increasing riming: in the initial stage (FR < 0.5), the aspect ratio increases very slowly, while in the later stage (FR > 0.5), the aspect ratio increases rapidly. Direct observations of the continuous changes in the shapes of snowflakes with riming are in good agreement with the retrieval results of radar.
Unraveling the Combined Effects of Ice and Permafrost on Arctic Delta Morphodynamics
Authors: Piliouras A. , Lauzon R. , Rowland J. C.
Published: March 2021

Arctic delta channel dynamics and coastal deposition patterns are uniquely affected by ice and permafrost. Building on previous experiments that documented the individual effects of ice and permafrost, we conducted new numerical modeling experiments to examine the combined influences of ice thickness and permafrost erodibility. We quantified the effects of ice, permafrost, and their combination on channel migration, avulsion, and persistence; onshore and nearshore deposition; and large‐scale delta morphology. Both ice and permafrost limited channel mobility, enhanced overbank deposition, and roughened shorelines. Thick ice increased offshore channel incision and sediment delivery. Permafrost stabilized channels and focused deposition that led to enhanced channel levee development. The increased levee deposition limited widespread channel infilling leading to the preservation of abandoned channels. Levee growth was enhanced by overbank flooding due to ice‐driven changes in water surface elevations. This flooding led to more extensive levees on deltas with both ice and permafrost compared to deltas with only permafrost. Ice also preserved small channels, leading to size‐dependent channel persistence: the presence of ice in the channels reduced the fraction of time small channels remained active relative to larger channels. Resistant permafrost damped this effect, as smaller and more distal channels were active earlier in the flood on deltas with resistant permafrost likely due to the smaller number of channels on permafrost‐laden deltas. Finally, our results suggest that the loss of both ice and permafrost will increase channel mobility, decrease overbank flooding, increase shoreline progradation rates, and decrease offshore transport of riverine fluxes.
Reply to Comment by Zhao et al. on “Paleomagnetism of the Late Cretaceous Red Beds From the Far Western Lhasa Terrane: Inclination Discrepancy and Tectonic Implications”
Authors: Bian Weiwei , Yang Tianshui
Published: March 2021

In this manuscript, we checked all the pieces of evidence separately and conclude that the evidence Zhao et al. (2021, https://doi.org/10.1029/2020TC006520) provided cannot be regarded as arguments supporting their points. Our observations show that (i) sampling units and depositional environment support that the Jingzhushan Formation red beds could be affected by the syntectonic sedimentation, (ii) characteristic remanent magnetization directions observed from the Jingzhushan Formation red beds represent primary magnetization acquired during the syntectonic sedimentation, not secondary remagnetization due to strain reorientation of remanence, and (iii) inclination discrepancy of the Jingzhushan Formation red beds could be attributed to syntectonic sedimentation. Therefore, the paleomagnetic results obtained from the Jingzhushan Formation red beds are reliable for paleogeographic reconstructions.
Sediment Management for Reservoir Sustainability and Cost Implications Under Land Use/Land Cover Change Uncertainty
Authors: Shrestha Bikesh , Cochrane Thomas A. , Caruso Brian S. , Arias Mauricio E. , Wild Thomas B.
Published: March 2021

Addressing uncertainty in sediment predictions due to land use/land cover (LULC) change could better inform the selection of sediment management options for reservoir sustainability. We used the Nam Kong catchment of the Mekong River Basin in Southern Laos, with two hydropower dams in series, to understand the implications of LULC change uncertainty for catchment‐level and reservoir‐level sediment management options. The catchment‐level sediment management options of terracing, vegetative filter strips, and no tillage were evaluated applying the Soil and Water Assessment Tool (SWAT). The reservoir‐level sediment management option of flushing was assessed using the Sediment Simulation Screening Python Model (PySedSim). Costs of sediment management options were assessed via the economic value of the loss in hydropower production and the avoided cost of dredging. Our results suggest that LULC projections resulted in high variability in loss of reservoir capacity and cost of sediment management. Terracing was found to be the best catchment‐level management option at decreasing both the magnitude and variability in loss of reservoir storage for both dams, but it was also the most expensive option. Flushing was also effective in reducing sedimentation, but it was less economically beneficial compared to catchment‐level sediment management options. Combinations of catchment‐level and reservoir‐level management strategies, however, can be effective in reducing the magnitude and variability in loss of reservoir storage and associated costs in response to LULC change uncertainty.
Changing River Network Synchrony Modulates Projected Increases in High Flows
Authors: Rupp David E. , Chegwidden Oriana S. , Nijssen Bart , Clark Martyn P.
Published: March 2021

Projections of change in high‐flow extremes with global warming vary widely among, and within, large midlatitude river basins. The spatial variability of these changes is attributable to multiple causes. One possible and little‐studied cause of changes in high‐flow extremes is a change in the synchrony of mainstem and tributary streamflow during high‐flow extremes at the mainstem‐tributary confluence. We examined reconstructed and simulated naturalized daily streamflow at confluences on the Columbia River in western North America, quantifying changes in synchrony in future streamflow projections and estimating the impact of these changes on high‐flow extremes. In the Columbia River basin, projected flow regimes across colder tributaries initially diverge with warming as they respond to climate change at different rates, leading to a general decrease in synchrony, and lower high‐flow extremes, relative to a scenario with no changes in synchrony. Where future warming is sufficiently large to cause most subbasins upstream from a confluence to transition toward a rain‐dominated, warm regime, the decreasing trend in synchrony reverses itself. At one confluence with a major tributary (the Willamette River), where the mainstem and tributary flow regimes are initially very different, warming increases synchrony and, therefore, high‐flow magnitudes. These results may be generalizable to the class of large rivers with large contributions to flood risk from the snow (i.e., cold) regime, but that also receive considerable discharge from tributaries that drain warmer basins.
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway
Authors: Wan Xinxing , Zhu Liyong , Zhao Liling , Peng Lin , Xiong Jing , Yang Wenjun , Yuan Jingjing , Liang Fang , Zhang Keke , Chen Ke
Published: March 2021

The period circadian regulator 3 (PER3) has been reported to play a negative role in human immortalized bone marrow-derived Scp-1 cells (iBMSCs) and patient adipose-derived stromal cells (PASCs) or a negative/positive role in mice adipogenesis. However, human PER3 (hPER3) was identified as a positive regulator of human adipose tissue-derived stromal cells (hADSCs) adipogenesis in this study. Silencing or overexpression of hPER3 in hADSCs inhibited and promoted adipogenesis in vitro. In vivo, the overexpression of hPER3 increased high-fat diet-induced inguinal white adipose tissue (iWAT) and epididymal white adipose tissue (eWAT) forms, increasing systemic glucose intolerance and insulin resistance. Molecularly, hPER3 does not interact with hPPARγ, but represses Notch1 signaling pathway to enhance adipogenesis by interacting with hHSP90AA1, which is able to combine with the promoter of hNotch1 and inactivate its expression. Thus, our study revealed hPER3 as a critical positive regulator of hADSCs adipogenesis, which was different from the other types of cells, providing a critical role of it in treating obesity.
Real-time molecular-level visualization of mass flow during patterned photopolymerization of liquid-crystalline monomers
Authors: Ueda Keisuke , Aizawa Miho , Shishido Atsushi , Vacha Martin
Published: March 2021

Single-particle fluorescence imaging is used to monitor dynamic processes that occur during patterned photopolymerization of liquid-crystalline monomers. A spatial gradient of chemical potential can be created at the border of bright and dark regions by structured illumination in the photopolymerization process, leading to mutual diffusion of polymers and monomers. Analysis of the fluorescence from single quantum dots doped into the monomers at minute concentrations enables visualization of highly directional flow from the illuminated region where the photopolymerization proceeds toward a masked unpolymerized region. This directional mass flow causes flow-induced orientation of the polymers that is subsequently fixed by completion of the polymerization reaction, resulting in a mesoscopic aligned area of the polymer film.
Unsafe “crossover-use” of chloramphenicol in Uganda: importance of a One Health approach in antimicrobial resistance policy and regulatory action
Authors: McCubbin Kayley D. , Ramatowski John W. , Buregyeya Esther , Hutchinson Eleanor , Kaur Harparkash , Mbonye Anthony K. , Mateus Ana L. P. , Clarke Sian E.
Published: March 2021

Since the introduction of antibiotics into mainstream health care, resistance to these drugs has become a widespread issue that continues to increase worldwide. Policy decisions to mitigate the development of antimicrobial resistance are hampered by the current lack of surveillance data on antibiotic product availability and use in low-income countries. This study collected data on the antibiotics stocked in human (42) and veterinary (21) drug shops in five sub-counties in Luwero district of Uganda. Focus group discussions with drug shop vendors were also employed to explore antibiotic use practices in the community. Focus group participants reported that farmers used human-intended antibiotics for their livestock, and community members obtain animal-intended antibiotics for their own personal human use. Specifically, chloramphenicol products licensed for human use were being administered to Ugandan poultry. Human consumption of chloramphenicol residues through local animal products represents a serious public health concern. By limiting the health sector scope of antimicrobial resistance research to either human or animal antibiotic use, results can falsely inform policy and intervention strategies. Therefore, a One Health approach is required to understand the wider impact of community antibiotic use and improve overall effectiveness of intervention policy and regulatory action.
A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
Authors: Coelho Camila H. , Tang Wai Kwan , Burkhardt Martin , Galson Jacob D. , Muratova Olga , Salinas Nichole D. , Alves e Silva Thiago Luiz , Reiter Karine , MacDonald Nicholas J. , Nguyen Vu , Herrera Raul , Shimp Richard , Narum David L. , Byrne-Steele Miranda , Pan Wenjing , Hou Xiaohong , Brown Brittany , Eisenhower Mary , Han Jian , Jenkins Bethany J. , Doritchamou Justin Y. A. , Smelkinson Margery G. , Vega-Rodríguez Joel , Trück Johannes , Taylor Justin J. , Sagara Issaka , Healy Sara A. , Renn Jonathan P. , Tolia Niraj H. , Duffy Patrick E.
Published: March 2021

Malaria elimination requires tools that interrupt parasite transmission. Here, we characterize B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230 kDa gamete surface protein Pfs230, a key protein in sexual stage development ofP. falciparumparasites. Among nine Pfs230 human monoclonal antibodies (mAbs) that we generated, one potently blocks transmission to mosquitoes in a complement-dependent manner and reacts to the gamete surface; the other eight show only low or no blocking activity. The structure of the transmission-blocking mAb in complex with vaccine antigen reveals a large discontinuous conformational epitope, specific to domain 1 of Pfs230 and comprising six structural elements in the protein. The epitope is conserved, suggesting the transmission-blocking mAb is broadly functional. This study provides a rational basis to improve malaria vaccines and develop therapeutic antibodies for malaria elimination.
Author Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types
Authors: Yuste Rafael , Hawrylycz Michael , Aalling Nadia , Aguilar-Valles Argel , Arendt Detlev , Armañanzas Ruben , Ascoli Giorgio A. , Bielza Concha , Bokharaie Vahid , Bergmann Tobias Borgtoft , Bystron Irina , Capogna Marco , Chang YoonJeung , Clemens Ann , de Kock Christiaan P. J. , DeFelipe Javier , Dos Santos Sandra Esmeralda , Dunville Keagan , Feldmeyer Dirk , Fiáth Richárd , Fishell Gordon James , Foggetti Angelica , Gao Xuefan , Ghaderi Parviz , Goriounova Natalia A. , Güntürkün Onur , Hagihara Kenta , Hall Vanessa Jane , Helmstaedter Moritz , Herculano-Houzel Suzana , Hilscher Markus M. , Hirase Hajime , Hjerling-Leffler Jens , Hodge Rebecca , Huang Josh , Huda Rafiq , Khodosevich Konstantin , Kiehn Ole , Koch Henner , Kuebler Eric S. , Kühnemund Malte , Larrañaga Pedro , Lelieveldt Boudewijn , Louth Emma Louise , Lui Jan H. , Mansvelder Huibert D. , Marin Oscar , Martinez-Trujillo Julio , Chameh Homeira Moradi , Mohapatra Alok Nath , Munguba Hermany , Nedergaard Maiken , Němec Pavel , Ofer Netanel , Pfisterer Ulrich Gottfried , Pontes Samuel , Redmond William , Rossier Jean , Sanes Joshua R. , Scheuermann Richard H. , Serrano-Saiz Esther , Staiger Jochen F. , Somogyi Peter , Tamás Gábor , Tolias Andreas Savas , Tosches Maria Antonietta , García Miguel Turrero , Wozny Christian , Wuttke Thomas V. , Liu Yong , Yuan Juan , Zeng Hongkui , Lein Ed
Published: March 2021

A Correction to this paper has been published: https://doi.org/10.1038/s41593-020-00779-0.
Linking prokaryotic community composition to carbon biogeochemical cycling across a tropical peat dome in Sarawak, Malaysia
Authors: Dom Simon Peter , Ikenaga Makoto , Lau Sharon Yu Ling , Radu Son , Midot Frazer , Yap Mui Lan , Chin Mei-Yee , Lo Mei Lieng , Jee Mui Sie , Maie Nagamitsu , Melling Lulie
Published: March 2021

Tropical peat swamp forest is a global store of carbon in a water-saturated, anoxic and acidic environment. This ecosystem holds diverse prokaryotic communities that play a major role in nutrient cycling. A study was conducted in which a total of 24 peat soil samples were collected in three forest types in a tropical peat dome in Sarawak, Malaysia namely, Mixed Peat Swamp (MPS), Alan Batu (ABt), and Alan Bunga (ABg) forests to profile the soil prokaryotic communities through meta 16S amplicon analysis using Illumina Miseq. Results showed these ecosystems were dominated by anaerobes and fermenters such as Acidobacteria, Proteobacteria, Actinobacteria and Firmicutes that cover 80–90% of the total prokaryotic abundance. Overall, the microbial community composition was different amongst forest types and depths. Additionally, this study highlighted the prokaryotic communities’ composition in MPS was driven by higher humification level and lower pH whereas in ABt and ABg, the less acidic condition and higher organic matter content were the main factors. It was also observed that prokaryotic diversity and abundance were higher in the more oligotrophic ABt and ABg forest despite the constantly waterlogged condition. In MPS, the methanotroph Methylovirgula ligni was found to be the major species in this forest type that utilize methane (CH4), which could potentially be the contributing factor to the low CH4 gas emissions. Aquitalea magnusonii and Paraburkholderia oxyphila, which can degrade aromatic compounds, were the major species in ABt and ABg forests respectively. This information can be advantageous for future study in understanding the underlying mechanisms of environmental-driven alterations in soil microbial communities and its potential implications on biogeochemical processes in relation to peatland management.
Validation and verification of predictive salivary biomarkers for oral health
Authors: Bostanci Nagihan , Mitsakakis Konstantinos , Afacan Beral , Bao Kai , Johannsen Benita , Baumgartner Desirée , Müller Lara , Kotolová Hana , Emingil Gülnur , Karpíšek Michal
Published: March 2021

Oral health is important not only due to the diseases emerging in the oral cavity but also due to the direct relation to systemic health. Thus, early and accurate characterization of the oral health status is of utmost importance. There are several salivary biomarkers as candidates for gingivitis and periodontitis, which are major oral health threats, affecting the gums. These need to be verified and validated for their potential use as differentiators of health, gingivitis and periodontitis status, before they are translated to chair-side for diagnostics and personalized monitoring. We aimed to measure 10 candidates using high sensitivity ELISAs in a well-controlled cohort of 127 individuals from three groups: periodontitis (60), gingivitis (31) and healthy (36). The statistical approaches included univariate statistical tests, receiver operating characteristic curves (ROC) with the corresponding Area Under the Curve (AUC) and Classification and Regression Tree (CART) analysis. The main outcomes were that the combination of multiple biomarker assays, rather than the use of single ones, can offer a predictive accuracy of > 90% for gingivitis versus health groups; and 100% for periodontitis versus health and periodontitis versus gingivitis groups. Furthermore, ratios of biomarkers MMP-8, MMP-9 and TIMP-1 were also proven to be powerful differentiating values compared to the single biomarkers.
HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors
Authors: Sulliman Nora Cassam , Ghaddar Batoul , Gence Laura , Patche Jessica , Rastegar Sepand , Meilhac Olivier , Diotel Nicolas
Published: March 2021

High density lipoproteins (HDLs) display pleiotropic functions such as anti-inflammatory, antioxidant, anti-protease, and anti-apoptotic properties. These effects are mediated by four main receptors: SCARB1 (SR-BI), ABCA1, ABCG1, and CD36. Recently, HDLs have emerged for their potential involvement in brain functions, considering their epidemiological links with cognition, depression, and brain plasticity. However, their role in the brain is not well understood. Given that the zebrafish is a well-recognized model for studying brain plasticity, metabolic disorders, and apolipoproteins, it could represent a good model for investigating the role of HDLs in brain homeostasis. By analyzing RNA sequencing data sets and performing in situ hybridization, we demonstrated the wide expression of scarb1, abca1a, abca1b, abcg1, and cd36 in the brain of adult zebrafish. Scarb1 gene expression was detected in neural stem cells (NSCs), suggesting a possible role of HDLs in NSC activity. Accordingly, intracerebroventricular injection of HDLs leads to their uptake by NSCs without modulating their proliferation. Next, we studied the biodistribution of HDLs in the zebrafish body. In homeostatic conditions, intraperitoneal injection of HDLs led to their accumulation in the liver, kidneys, and cerebral endothelial cells in zebrafish, similar to that observed in mice. After telencephalic injury, HDLs were diffused within the damaged parenchyma and were taken up by ventricular cells, including NSCs. However, they failed to modulate the recruitment of microglia cells at the injury site and the injury-induced proliferation of NSCs. In conclusion, our results clearly show a functional HDL uptake process involving several receptors that may impact brain homeostasis and suggest the use of HDLs as delivery vectors to target NSCs for drug delivery to boost their neurogenic activity.
Spin distillation cooling of ultracold Bose gases
Authors: Świsłocki Tomasz , Gajda Mariusz , Brewczyk Mirosław , Deuar Piotr
Published: March 2021

We study the spin distillation of spinor gases of bosonic atoms and find two different mechanisms in $${}^{52}$$

52

Cr and $$^{23}$$

23

Na atoms, both of which can cool effectively. The first mechanism involves dipolar scattering into initially unoccupied spin states and cools only above a threshold magnetic field. The second proceeds via equilibrium relaxation of the thermal cloud into empty spin states, reducing its proportion in the initial component. It cools only below a threshold magnetic field. The technique was initially demonstrated experimentally for a chromium dipolar gas (Naylor et al. in Phys Rev Lett 115:243002, 2015), whereas here we develop the concept further and provide an in-depth understanding of the required physics and limitations involved. Through numerical simulations, we reveal the mechanisms involved and demonstrate that the spin distillation cycle can be repeated several times, each time resulting in a significant additional reduction of the thermal atom fraction. Threshold values of magnetic field and predictions for the achievable temperature are also identified.