bluuebunny/crossref_metadata_2025 huggingface dataset:
O impacto da atividade física na saúde mental do adolescente: uma breve revisão de literatura
Authors: Da Igreja Júnior Sidney Mendes , Ribeiro Danielle Rodrigues , Gonçalves Maíra Lima Santos , Araújo Juliana de Sousa Santos , Santana Breno Wagner Paes
Published: July 2023

Objetivo: O presente estudo tem como objetivo identificar, através de uma revisão de literatura, evidências acerca dos efeitos da atividade física na saúde mental dos adolescentes. Metodologia: A busca e seleção dos artigos utilizados foi feita entre agosto e outubro de 2022, foram usados artigos de 3 bases de dados: Pubmed, Scielo e Lilacs. Inicialmente, a seleção dos artigos foi feita utilizando como descritores: ´´Ansiedade``, ´´Saúde mental``, ´´Atividade física``, ´´Esporte`` e ´´Adolescente``, com o uso dos descritores booleanos ´´OR`` e ´´AND``. Foi encontrado um total de 92 artigos e após o final do processo de filtragem e leitura foram incluídos 4 artigos na revisão. Resultados: Os estudos analisados nessa revisão, trazem uma abordagem focada na relação entre a prática de atividade física rotineira, voltada para o lazer e a saúde e os benefícios no contexto da saúde mental, além de demonstrar a importância negativa do sedentarismo na mesma situação. Conclusão: A realização de atividades físicas se faz necessária no ambiente escolar e nos momentos de lazer durante a adolescência, sendo essa prática de forma moderada a vigorosa por, pelo menos 300 minutos por semana. Os artigos estudados evidenciaram entre os praticantes de exercícios físicos a presença de menores prevalências de transtornos mentais, sintomas ansiosos e depressivos, assim como, melhoria na qualidade do sono, autoestima, bem-estar e qualidade de vida.
O potencial do ensino a distância em cidades inteligentes: um estudo de caso
Authors: Dias Cristina , Santos Carla
Published: July 2023

As cidades inteligentes vivem de mãos dadas com a tecnologia, e detêm a capacidade de conjugar vários aspetos inovadores e fundamentais como a, sustentabilidade, autonomia administrativa, comunicações e recursos educacionais. Segundo a UNESCO, a educação é um direito humano fundamental e, o seu acesso universal com igual qualidade, deve ser concedido aos cidadãos de todas as nações. Como essa meta ainda não foi alcançada na maioria dos países, é extremamente importante encontrar maneiras mais eficazes de melhorar o acesso à educação. As novas tecnologias e o ensino a distância, têm vindo a desempenhar um papel fundamental na melhoria e facilidade de acesso a uma educação cada vez mais inclusiva, de e para todos, independentemente do ponto do globo onde nos encontremos. Assim, neste trabalho, através de uma revisão sistemática da literatura, analisa-se o uso das tecnologias no ensino a distância no ensino básico, secundário e superior, na área de matemática, durante a pandemia por COVID-19. Interessou-nos, também, perceber se os docentes, tiraram partido destas ferramentas, para desenvolverem ambientes de aprendizagem inovadores, que favoreçam a interação entre o docente e o aluno. A pesquisa é de natureza qualitativa de caráter descritivo e exploratório, utilizando como procedimentos técnicos uma revisão completiva da literatura sobre a temática abordada. A pesquisa foi realizada por meio de artigos indexados nas bases de dados eletrônicos na Science Direct, Google Scholar, B-on e JSTOR, publicados em português e inglês, de janeiro de 2015 a maio de 2021, considerando as seguintes palavras chave: Ensino a distância, Matemática, Tecnologias, Educação, Pandemia COVID-19. Utilizou-se como critério de inclusão a coerência com o tema, e de exclusão a repetição de artigos ou não adequação do tema. A amostra inicial foi de 77 artigos (n= 77), que após aplicados os critérios anteriormente descritos, ficou reduzida a 14 (n=14). Depois de efetuada a análise dos artigos, foi possível concluir que a utilização e inclusão das tecnologias digitais no ensino a distância, facilitaram e possibilitaram a qualidade do ensino, contribuindo ainda, para melhorar a formação dos docentes que de forma inesperada foram “forçados” a utilizar as novas tecnologias no processo de ensino-aprendizagem.
Perfil e prevalência da Tuberculose no estado de Alagoas no período de 2018 a 2022
Authors: De Sousa Saulo Batista , Vieira Matheus Emannuel Santos , Da Luz Gabriela Aragão , Gomes Luis Henrique Alves , Pol-Fachin Laércio
Published: July 2023

Introdução: A tuberculose (TB) é uma enfermidade infecto-contagiosa que afeta principalmente o trato respiratório do indivíduo e é causada por uma bactéria patogênica específica denominada Mycobacterium tuberculosis (MT). Essa doença atinge o Brasil e o mundo, sendo considerada um grande problema de saúde pública. Segundo a Organização Mundial da Saúde (OMS), mais de duas bilhões de pessoas estão infectadas por MT, o que corresponde a aproximadamente um terço da população mundial. No Brasil a região predominante é o subúrbio das grandes cidades quando se trata da população mais acometida. Atrelado a falta de higiene e moradia insalubre que contribuem para a disseminação do bacilo na região. Objetivo: Avaliar a epidemiologia e prevalência da infecção em um estado do nordeste brasileiro, bem como compará-lo com a situação geral do país e com dados encontrados na literatura. Metodologia: Trata-se de um estudo descritivo, de caráter quantitativo, da base de dados SINAN/DATASUS, dentre eles: pacientes com tuberculose a partir de variáveis como: sexo, ano de diagnóstico nos últimos cinco anos no estado de Alagoas e no Brasil. Resultados e discussões:  O número total de pacientes diagnosticados com tuberculose no Estado de Alagoas foi de 5985 novos casos durante os anos de 2018 a 2022. Os alagoanos com tuberculose correspondem a aproximadamente 1,29%% do total nacional. A análise dos dados do SINAN em Alagoas mostrou convergência das informações com a literatura, revelando a prevalência do sexo masculino, com quase o dobro do número de casos do sexo feminino. possível justificativa para a redução importante do número de casos nos últimos dois anos se deve ao diagnóstico precoce e adequado, reforçado pelo Ministério da Saúde. Conclusão: Diante do cenário muito prevalente de infecção Tuberculose, torna-se necessário que novas políticas públicas surjam em favor da redução da desigualdade social, econômica e regional.
El desarrollo de habilidades blandas en la formación integral de estudiantes de licenciatura
Authors: Deserti Elia Olea , Castillo Martha Elisa Cortés
Published: July 2023

La pandemia del COVID-19 a nivel mundial tuvo repercusiones en todos los aspectos del contexto en que se vive, resaltando el educativo, en el que se observó un cambio emocional en los estudiantes. Dicha situación llevó al análisis curricular en el que existe gran preocupación por el desarrollo de las habilidades cognitivas o duras y se presupone que las habilidades socioemocionales o blandas son reconocidas y manejadas adecuadamente, lo que favoreció reflexionar en la formación integral de los estudiantes de licenciatura en los que ambos tipos de habilidades son necesarias para el ámbito laboral. Así que se planeó realizar una investigación acción en estudiantes de licenciatura de una escuela pública con el objetivo de desarrollar/fortalecer sus habilidades blandas con apoyo en las funciones tutoriales de sus docentes. Se partió de un sondeo realizado a una muestra de n = 53 estudiantes de la licenciatura en Administración y Desarrollo Empresarial y se averiguó información clave que permitió inferir, a partir de sus características personales, las problemáticas socioemocionales más urgentes que habría que atender. Se elaboró el cuadernillo “Acompañamiento para la vida” como una estrategia a usar por los docentes tutores quienes, junto con sus estudiantes, analizarían el contenido y los discentes realizarían actividades que les ayudaran al fortalecimiento de sus habilidades blandas.
Lean Logistics 4.0: concepts and key performance indicators
Authors: Rodrigues Ana Lígia Vieira , Gomes Guilherme , Bouzon Marina
Published: July 2023

Paper aims: To encourage the use of the combination of Logistics, Industry 4.0 and Lean Manufacturing, this article proposes, through a literature review, following the Prisma methodology, to define the concept of Lean Logistics 4.0 and to present performance indicators, selected by 15 specialists using the methodology AHP, that can help organizations in their actions towards the future of logistics, through a dashboard based on 8 KPI´s Originality: The literature shows that there is a lack of studies focusing on the relationship between the concepts of Lean Manufacturing and Industry 4.0 applied to Logistics. It can be observed that only two articles contemplate the theme of Logistics 4.0 related to the concepts of Lean Manufacturing. Research method: A review was carried out in the literature to define the concept of Lean Logistics 4.0 and the AHP methodology was applied with 15 experts in the field to select key performance indicators to measure and guide the performance of companies through Lean Logistics 4.0. Main findings: In addition to the definition of the concept of Lean Logistics 4.0, the research provided through the AHP method a dashboard based on 8 key performance indicators: Investment/innovations in automation and new equipment, Handling and Transportation Waste, Workforce Flexibility, Lead Time, Predictive/prescriptive capacity, Punctuality and Completeness of Delivery, Total Logistics Cost, and Setup Reduction. Implications for theory and practice: The research revealed that some benefits can be exploited in companies operating with Lean Logistics 4.0 and this article provides a perspective of performance indicators that can guide organizations towards the application of the concept and the continuous improvement of logistics flows.
PENGEMBANGAN INSTRUMENT MISKONSEPSI MENGGUNAKAN DREAMWEAVER BERBASIS WEB PADA MATERI TEKANAN BERFORMAT FIVE-TIER
Authors: Sandra Rizka Octavia , Maison Maison , Kurniawan Dwi Agus
Published: July 2023

Penelitian ini merupakan penelitian pengembangan Research dan Developmet (R&D) yang dimana menggunakan model pengembangan ADDIE (Analisys, Design, Development, Implementation dan Evaluation). Dalam penelitian ini hanya sebatas pada tahapan implementasi karena pada tahap implementasi ini tujuan dari penelitian telah terpenuhi. Tujuan dari penelitian ini adalah untuk mengambangkan instrument five-tier diagnostic test berbasis web untuk dapat mengidentifikasi miskonsepsi yang terjadi pada siswa SMA dalam materi tekanan disekolah. Instrumen yang digunakan dalam pengumpulan data yaitu didapatkan dari hasil angket validasi ahli media, validasi instrument soal dan respon siswa. Hasil yang didapatkan dari penelitian pengembangan ini menunjukkan bahwa produk yang dikembangkan dapat digunakan karena telah dilakukan validasi ahli media oleh dua validator yaitu validator 1 dan validator 2 untuk mengetahui kelayakan dari produk yang akan dikembangkan. Dengan demikian dari hasil yang telah didapatkan dimana produk yang dikembangkan dikategorikan layak untuk digunakan oleh guru dalam melakukan identifikasi miskonsepsi yang terjadi pada siswa dalam materi tekanan disekolah.
A STUDY TO ASSESS THE EFFECTIVENESS OF STRUCTURED TEACHING PROGRAMME REGARDING MOBILE PHONE USAGE ON SLEEP AMONG B.SC. NURSING STUDENTS AT SRM COLLEGE OF NURSING, KATTANKULATHUR.
Authors: Gupta Ranjana , Yadav Kopila , Yadav Sabita , Mary Devakani. J Selva
Published: July 2023

Introduction: Smart phone have become a pervasive part of our daily lives but the continuous usage and craving to mobile phone has affected the
people in various aspects like psychologically, physically and socially. To a Objectives: ssess the study of pretest and post test level of mobile
phone usage and sleep among of B.Sc. Nursing students, To determine the effectiveness of Structured Teaching Programme regarding mobile
phone usage on sleep among B.Sc. Nursing students. Quasi experimental pre test a Method: nd post test only design for the study. 195 students who
fullled the inclusion criteria were selected by using non probability convenient sampling method. Structured questionnaire was used to assess the
demographical variables and standard questionnaires used for mobile phone use and sleep pattern. Reliability of the tool established by split half
method. Results: In pre test, majority (83%) of subjects were had severe addiction, (17%) of them had moderate addiction on smartphone; (100%)
of subjects were had poor sleep. Whereas in post test majority (98%) of subjects were had moderate addiction, (2%) of them had mild addiction on
smartphone; majority (88%) of B.Sc. nursing subjects were had poor sleep and (12%) of them had good sleep. There was highly signicant
(p<0.01) association between “Age and Year of present graduation” and “Cell phone addiction” and there was signicant (p<0.05) association
between “monthly income” and “sleep quality”. Necessary to guide the stude Conclusion: nts regarding healthy usage and negative effects of
mobile phones.
AN OBSERVATIONAL STUDY OF IMMUNOPHENOTYPIC PATTERN IN MORPHOLOGICALLY DIAGNOSED CASES OF ACUTE MYELOID LEUKEMIA AT SMS MEDICAL COLLEGE, JAIPUR.
Authors: Mishra Deepika , Barman Shrabani , Choudhary Prerna , Nehra Anil
Published: July 2023

Background : The diagnosis and classication of AML were based on the French–American–British (FAB) system for nearly three decades. Morphological examinations of peripheral blood and bone marrow have consistently added value to this classication. Multiparameter ow cytometry is the preferred method of immunophenotypic analysis in AML due to the ability to analyze large numbers of cells in a relatively short period with simultaneous recording of information about several antigens for each cell. This observational type of cross Methods and Material : sectional study was carried out in the Pathology department, S.M.S. Medical College, Jaipur, during the period of 2021-2022. A total of 100 patients of all ages and both genders who were newly diagnosed with acute myeloid leukemia were included. Demographic data was noted. The samples were analysed for blast percentage and morphology on leishman stained peripheral blood and bone marrow smears. Immunophenotyping was done by ow cytometry. This included samples of peripheral blood or bone marrow aspirate from patients of morphologically diagnosed AML patients. Results : The most common subtype was AML- M2 and most commonly expressed antigen was CD33 followed by CD13.The mean positivity for CD33 among all AML subtypes was 98.94%. Aberrant expression of CD7 and CD19 were expressed in 5.32% and 4.26% of all cases respectively. There was concordance rate of 94% between morphology and FCM in our study. A combined eva Conclusion : luation of peripheral blood lm, bone marrow aspiration and ow cytometry were done. Flow cytometric analysis must always be performed in conjunction with cytomorphology for denitive diagnosis of acute myeloid leukemia.
Van İli Büyükbaş Hayvancılık İşletmelerinin Yem Temini ve Hayvan Besleme Alışkanlıkları
Authors: YILDIZ Serhat
Published: July 2023

Bu çalışmada, Van İli büyükbaş hayvancılık işletmelerinin genel durumları ile yem temini ve hayvan besleme alışkanlıklarının belirlenmesi, işletmelerin temel sorunlarının saptanarak çözüm önerilerinde bulunulması amaçlanmıştır. Bu çalışmanın materyalini, Van Yüzüncü Yıl Üniversitesi DAP Çiftçi Eğitim Merkezi’nin bünyesinde yapılan eğitimlere, Van ilinden katılan 137 kursiyerlere uygulanan anketler oluşturmaktadır. Araştırma sonuçlarına göre, ankete katılanların %84.56’sının 15-50 yaş arasında olduğu, ortaokul ve altı eğitim alanların oranının ise %57.04 olmuştur. Kursiyerlerin %75.63’ünün 5-100 dekar, %18.49’unun 100-250 dekar, %5.88’inin ise, 250 dekar ve üzeri tarım arazisi işledikleri belirlenmiştir. Katılımcıların işletmelerinde ortalama olarak 40.89 baş her yaştan sığır ve 3.00 baş mandaya sahip oldukları; kaba ve kesif yem ihtiyaçlarını dışarıdan karşılayanların oranı sırasıyla %31.67 ve %50.00; meradan faydalananların oranı %78.23; yonca yetiştirenler %34.75 ve işletmesinde silaj kullananlar %35.25 olarak tespit edilmiştir. Kursiyerlerin %61.60’ının hayvanlar için hazırlanan rasyonları, kendilerine göre hazırladıkları, hayvanlara tuz ve vitamin-mineral ilavesi yapanların oranı %81.25 olarak bulunmuştur. Ankete katılan birçok yetiştiricinin, hayvanları günde iki defa yemledikleri (%58.87) ve ahır içinde sabit suluğu bulunan işletmelerin oranı ise %24.39 olarak tespit edilmiştir.
Investigation of Reproductive Parameters in Male Geriatric (3 years old) Rats
Authors: KOŞAL Volkan , KELEŞ Ömer Faruk , KÖMÜROĞLU Ahmet Ufuk , BASBUGAN Yıldıray
Published: July 2023

Many health problems are seen due to aging. One of these is problems in the reproductive system. Reproductive system problems are caused by lower urinary system symptoms, prostate diseases, low fertility, testicular dysfunction. The aim of this study was to compare reproductive parameters of geriatric (3 years old) and young (3 months old) rats. A 3-year-old rat is equivalent to an average 90-95-year-old human. For this purpose, sperm analysis, testicular and prostate histopathology, testicular oxidative stress parameters were examined in geriatric (3 years old) and young (3 months old) rats. In the analysis results, it was determined that sperm motility ratio decreased (p<0.001), abnormal sperm ratio increased (p<0.001) and sperm density decreased (p<0.001) in the geriatric group. Statistically, oxidative stress parameters MDA, AOPP, T-SH levels increased (p<0.05) and CAT level decreased (p<0.05) in geriatric group. Histopathologically, degeneration, necrosis and irregular alignments were observed in the tubulus seminiferous contortus in the geriatric group. Hyperplasia and dilatation of the prostate gland were detected in the geriatric group. As a result of this study, it is thought that reproductive performance in geriatric male rats is very low, and the probability of reproduction is very difficult.
Como Eu Faço Ultrassonografia Vascular nas Dolicoarteriopatias das Artérias Carótidas
Authors: Cantisano Armando Luis , Grubert Catarina Schiavo
Published: July 2023

Este artigo traz um passo a passo de orientações sobre como eu faço a investigação, classificação e avaliação anatômica e hemodinâmica das dolicoarteriopatias, frequentemente encontradas nas artérias carótidas e vertebrais. As dolicoarteriopatias podem estar presentes na população infantil, e podem desaparecer durante o crescimento e ressurgir na idade avançada. Consideradas anteriormente variações anatômicas (VAs) benignas, discussões sobre o tema vêm surgindo a partir de novas implicações por associações com eventos cardiovasculares, fatores de risco e diversas patologias.
Como Eu Faço Avaliação Ecocardiográfica no Pós-Transplante Cardíaco Pediátrico para Controle de Rejeição e/ou Doença Vascular do Enxerto
Authors: Siqueira Adailson Wagner da Silva , Almeida Mirela Frederico de
Published: July 2023

O transplante cardíaco pediátrico é escolha terapêutica definitiva para os pacientes com insuficiência cardíaca refratária ao tratamento clínico otimizado, seja em decorrência de cardiomiopatias ou cardiopatia congênita. A morbimortalidade permanece como fator de preocupação durante a evolução, sendo disfunção primária, rejeição e doença vascular do enxerto (DVE) as principais causas de morte nos primeiros 5 anos pós-transplante. O ecocardiograma transtorácico como método de vigilância apresenta benefícios significativos no auxílio diagnóstico quanto à suspeita clínica de rejeição ou de DVE. O objetivo deste artigo é trazer de forma clara e objetiva quais dados ecocardiográficos auxiliarão o cardiologista pediátrico no seguimento do paciente transplantado. O uso do ecocardiograma, seja através das ferramentas convencionais ou através de métodos avançados, direcionado e atento às diferentes fases do pós-transplante cardíaco, precoce e tardio, com as informações de exame atual e comparativo evolutivamente, principalmente quanto ao Doppler tecidual (TDI) e strain longitudinal, pode auxiliar ao cardiologista pediátrico na decisão de antecipar a biopsia endomiocárdica e coronariografia (padrão ouro) para diagnóstico precoce e imediata intervenção, permitindo maior durabilidade do enxerto.
Como Eu Faço Ecocardiografia Tridimensional para Classificação Fisiopatológica da Regurgitação Tricúspide
Authors: Felix Alex dos Santos , Alcantara Monica Luiza de , Papadopoulos Konstantinos
Published: July 2023

Embora conhecida no passado como a “valva esquecida”, nas duas últimas décadas houve um interesse crescente no estudo da valva tricúspide (VT). A regurgitação tricúspide (RT) tem sido identificada como um marcador prognóstico não apenas quando associada a outras doenças cardíacas, como insuficiência cardíaca, regurgitação mitral ou estenose aórtica, – mas também como uma entidade isolada. Compreender os mecanismos fisiopatológicos desta doença é de suma importância, pelo desenvolvimento de novas opções de dispositivos e técnicas transcateter, oferecendo tratamento invasivo para pacientes de alto risco para os quais a intervenção cirúrgica não seria adequada.

É difícil obter imagens da VT na ecocardiografia transesofágica pelos seguintes motivos: 1) os folhetos são muito mais finos em comparação com os folhetos mitrais, com maior variabilidade anatômica; 2) é uma estrutura anterior, distante do esôfago, com sombra acústica do esqueleto fibroso do coração; e 3) não pode ser alinhado com a sonda esofágica para adquirir imagens en face e requer o uso de resolução lateral. Essas restrições podem limitar a capacidade da ecocardiografia transesofágica tradicional de avaliar a TV, tornando-se necessário complementar a avaliação com janelas especiais do esôfago inferior e transgástricas. Diferentemente de outras valvas cardíacas, as imagens da VT obtidas por ecocardiografia transtorácica costumam ter melhor resolução do que as imagens obtidas pela ecocardiografia transesofágica. Embora todos os protocolos comecem com a avaliação bidimensional (2D) da VT, a ecocardiografia tridimensional (3D) desempenha um papel importante na avaliação das doenças da VT, não apenas por sua capacidade de retratar com precisão a anatomia da valva e do aparelho subvalvar, mas também pela sua acurácia na quantificação dos volumes e da função do ventrículo direito (VD) e do átrio direito, bem como da análise funcional da disfunção valvar, especialmente para graduar a RT e avaliar a dinâmica do anel tricúspide por meio de software dedicado. Todas essas informações são de importância inigualável para o manejo do paciente e o planejamento pré-procedimento em abordagens cirúrgicas e transcateter.
MENTAL HEALTH, QUALITY OF LIFE, SPIRITUAL DRYNESS AND ACEDIA SYMPTOMS IN PATIENTS SUFFERING FROM CHRONIC DISEASES
Authors: Fradelos Evangelos C. , Saridi Maria , Bakalis Vissarion , Toska Aikaterini , Vus Viktor , Büssing Arndt , Souliotis Kyriakos
Published: July 2023

The aim of the present study is to examine mental health, quality of life, acedia and spiritual dryness in patients suffering from chronic diseases.
Materials and method: Data were collected by special design instrument for the needs of the present study. Descriptive statistics and inferential statistics were applied and the analysis was carried out with IBM SPSS 26 and JASP 0.14.01.
Results: From the total of 210 participants, 106 (50.4%) were male, the mean age was 62.9 years, and the majority of them were diagnosed with type 2 diabetes. 50 (23.8%) of the participants suffer from anxiety and 39 (18.6%) from depression. In addition, 17.1% experience phases of spiritual dryness frequently or regularly. Physical quality of life component, was associated with the following variables: live from faith, psychological wellbeing, type of disease and age. This model can predict 31.1% of the variance. In terms of psychological wellbeing, the variables living arrangement, awe/gratitude, anxiety, and spiritual dryness can interpret 41.5% of the variance. When it comes to depression, we found that wellbeing, awe/gratitude are predictors of depressive symptoms, explaining at least 14.1% of the variance. Finally, anxiety can be predicted by wellbeing, awe/gratitude, and the type of the disease, interpreting 17.2% of the variance.
Conclusions: Patients suffering from chronic diseases are experiencing spiritual dryness and acedia symptoms, and those aspects can be associated with various domains of health and wellbeing.
DYNAMICS OF STUDENTS’ PHYSICAL WELL-BEING INDICATORS DURING QUARANTINE RESTRICTIONS
Authors: Sabirov Oleksandr O. , Syrovatko Zoia V. , Yefremenko Viktoriia M. , Havrylova Nataliia Ye. , Syrotynska Olena K. , Chekhovska Anna Yu. , Mokhunko Oleksandr D.
Published: July 2023

The aim: To study the dynamics of students’ physical well-being and physical fitness during the quarantine restrictions caused by the COVID-19 pandemic.
Materials and methods: The research involved 263 students (148 men and 115 women) aged 18-20. Depending on the volume of physical activity performed by students during quarantine restrictions, they were divided into three groups (with sufficient, high, and low volume). The physical well-being of students was determined by the method proposed by Ye. A. Pyrohova. The level of physical fitness was determined by the results of students’ performance of the exercises.
Results: The most pronounced negative changes in physical well-being indicators were found in group C students (both men and women), whose volume of motor activity during quarantine restrictions was low. Among the physical qualities, the level of endurance of students was the most negatively affected.
Conclusions: It was found that physical exercises have a positive effect on students’ physical well-being during quarantine restrictions. The rational use of physical education makes it possible to mobilize the reserve motor capabilities of the students’ body, offset the negative impact of low motor activity and sedentary lifestyle during quarantine restrictions, and help maintain the physical well-being and level of physical fitness at the proper level.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KESIAPSIAGAAN PERAWAT AMBULANS GAWAT DARURAT 118 DALAM MENGHADAPI KEGAWATDARURATAN BENCANA BANJIR DI DKI JAKARTA
Authors: Hardiyati Anastasia , Muhafilah Ilah
Published: July 2023

Latar belakang: Kesiapsiagaan merupakan serangkaian kegiatan yang dilakukan untuk mengantisipasi bencana melalui pengorganisasian serta melalui langkah tepat guna dan berdaya guna. Perawat memiliki tanggung jawab untuk meminimalisir dampak bencana dengan manajemen bencana. Terdapat banyak faktor (pengetahuan, sikap, pengalaman bencana, sarana dan prasarana serta kebijakan) yang dapat mempengaruhi kesiapsiagaan perawat. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang berhubungan dengan kesiapsiagaan perawat Ambulans Gawat Darurat 118 dalam menghadapi kegawatdaruratan bencana banjir di DKI Jakarta

Metode penelitian: Penelitian ini menggunakan metode analisis deskriptif dengan pendekatan cross-sectional yang dilakukan pada tanggal 8 Juni 2018 di Ambulans Gawat Darurat 118 Jakarta. Teknik pemilihan sample yang digunakan adalah total sampling yaitu sebanyak 38 responden dan penelitian dilakukan pada tanggal 8 Juni 2018. Data di analisis menggunakan uji statistik Chi Square pada tingkat kemaknaan 95% (α 0,05) .

Hasil: Sebagian besar perawat yang bekerja di Ambulans Gawat Darurat 118 Jakarta memiliki tingkat kesiapsiagaan yang tinggi (60,5%). Hasil analisis bivariat menunjukkan bahwa adanya hubungan yang signifikan antara pengetahuan [ P Value = 0,006 ; OR = 9,500], sikap [ P Value = 0,018; OR = 7,125], pengalaman bencana [ P Value = 0,041 ; OR = 5,400], kebijakan [ P Value = 0,005 ; OR = 9,900] serta sarana dan prasarana [ P Value= 0,006 ; OR = 9,500] dengan kesiapsiagaan perawat.

Kesimpulan: Pengetahuan, sikap, pengalaman bencana, kebijakan serta sarana dan prasarana merupakan faktor- faktor yang berhubungan dengan kesiapsiagaan perawat. Perawat dan masyarakat diharapkan mampu bekerjasama dengan lintas sektor yang terkait dalam kesiapsiagaan banjir di DKI Jakarta guna meminimalkan jumlah korban saat bencana terjadi, mengurangi trauma pada korban, mencegah munculnya masalah kesehatan pasca bencana, dan memudahkan upaya tanggap darurat serta pemulihan yang cepat.
Huesos de la cabeza neumatizados. Enfoque unitario
Authors: Benítez-Lorenzo Cándido Adalberto
Published: July 2023

Introducción: muchos huesos que forman el esqueleto de la cabeza humana y muchas especies de animales están neumatizados. Se han planteado múltiples hipótesis con diversos enfoques con la intención de explicar la existencia de estos espacios aéreos. De todos los huesos con estas características en humanos, solamente los senos paranasales y la neumatización del hueso temporal han sido objeto de múltiples hipótesis. La diversidad de criterios denota un desacuerdo, si no con todos, con la mayoría de ellos. Material y métodos: esta teoría se basa en reflexiones personales apoyadas en radiografías e imágenes anatómicas de los huesos frontal y temporal, con el objetivo de ilustrar y reforzar las razones de la existencia de estas cavidades en todas las especies que las poseen. Resultados, discusión y conclusiones: estos espacios de aire se forman en el cuerpo de los huesos cortos como un mecanismo de defensa natural al reemplazar el tejido esponjoso para prevenir infecciones graves del mismo (osteomielitis), que dada su proximidad al cerebro y sus estructuras representaría un peligro para la vida. Consideramos que los laberintos etmoidales fueron creados con el objetivo de llenar el espacio vacío entre los huesos vecinos y dar estabilidad al esqueleto óseo circundante. La neumatización del hueso temporal (hueso compacto) fue creada para “alojar y proteger” importantes estructuras de los sentidos del oído y del equilibrio, los vasos y los nervios.
Pharmacotherapy Safety 360°: NOLI NOCERE!
Authors: Sychev D. A.
Published: July 2023

The Russian Congress «Pharmacotherapy Safety 360°: NOLI NOCERE!» was successfully held at the Russian Ministry of Health in May 2023, providing a high-level, expert platform to discuss current and topical issues of pharmacovigilance and pharmacotherapy safety for different patient groups, including pediatrics, gerontology and geriatrics, pregnant women, patients with orphan and oncological diseases. Extensive scientific topics covered the most significant aspects of the pharmacotherapy safety in various fields, including cardiology, gastroenterology, pulmonology and allergology, endocrinology, neurology, oncology and psychiatry. Over 280 speakers, moderators and lecturers, Russian and foreign experts including world-renowned scientists participated in the discussion of the key tasks facing modern science. The Congress covered issues promising for the further development of biopharmaceuticals, related to the application of artificial intelligence and neural networks.
Rawls Düşüncesinde Örtüşen Görüş Birliği ve Makuliyet
Authors: SELİM Ferdi
Published: July 2023

Rawls'un siyasal liberalizmi, liberal demokrasinin felsefi bir açıklamasını sağlama şeklindeki geleneksel siyaset teorisi hedefini terk eder. Bununla birlikte Rawls, “modus vivendi” uzlaşması dediği şeyden daha derin gerekçelerle vatandaşlar tarafından onaylanan liberal bir siyasi düzeni de amaçlar. Fakat çoğulcu ve özgür bir liberalizm özlemi, rakip kapsamlı doktrinler arasında bir modus vivendi uzlaşmasından daha derin bir şey olarak onaylanan bir liberalizm hedefiyle çelişir görünmektedir. Bir uzlaşma yerine “kendi iyiliği için” desteklenen bir liberalizm, zorunlu olarak, siyasal liberalizmin çiğnediği türden bir tür iyi kavramına dayanmalıdır. Bizce bu nedenle Rawls siyaset felsefesinde kapsamlı olmayan, ancak yine de ahlaki bir gerekçe sunmaya çalışır. Her ne kadar Rawls’un görüşünü onaylayanlar sıklıkla bu tür eleştirilerin, felsefi olarak kapsamlı bir yol izlemekten başka ahlaki bir gerekçe sunulamayacağı şeklindeki asılsız varsayıma dayandığından şikâyet etseler de siyasal liberalizmi eleştiren pek çok kişi bunun başarılı olduğundan şüphe eder. Bu çalışmada, Rawls tarafından özellikle geç dönem yazılarda kullanılan gerekçelendirme stratejisi içsel olarak eleştirmeye çalışılacaktır. Siyasi meselelerle ilgili ihtilaf durumlarında vatandaşların siyasi değerlere siyasi olmayan değerlere göre öncelik vermesine dair bize makul bir umut sunamayacağına işaret edilecektir. Ayrıca, Rawls'un kapsamlı olmama, çoğulculuğu sağlama ve koruma kaygısına yönelik açıklamalarının eksikliklerinin gösterilmesi hedeflenmektedir.
Green Knowledge in Green Roofs and Organizational Green Innovation
Authors: Vargas-Hernandez José G. , Maillard Carlos Alberto A. Rodriguez , Vargas-González Omar C.
Published: July 2023

This study aims to analyze the implications of green knowledge and technology in organizational green innovation, urban green innovation, and green roofs. Green roofs can be an effective tool for cities to improve the thermal environment, save energy, combat climate change, and are an appropriate method of saving energy. The analysis is supported by the assumption that green technology is basic to organizational green innovation and urban green innovation areas practices, operations, and activities. Making the balance between urban developments and environmental issues, in consideration to sustainable development principle and its innovative green solutions. The methods employed are based on the analytical-reflective and descriptive supported with the review of theoretical and empirical literature. The analysis concludes that green knowledge sharing is relevant to create and develop green technology with positive implications for organizational green innovation, urban green innovation areas and green roofs.
Screening differential circular RNA expression profiles and the potential role of hsa_circ_0085465 in liver cancer
Authors: Zhou Churen , Zhu Duo , Zhou Sibin , Wang Haofan , Huang Mingsheng
Published: July 2023

Aims:

This study aimed to screen the circular RNAs (circRNAs) that are differentially expressed between liver cancer and paired paracarcinoma tissues and then elucidate their role in cancer progression.

Materials and Methods:

High-throughput sequencing of cancer and paired paracarcinoma tissues was followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of the parental genes of the differentially expressed circRNAs, which were also verified via real-time quantitative polymerase chain reaction analysis of the tissues. In addition, the function of selected circRNAs was determined using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4- sulfophenyl)-2H-tetrazolium (MTS) and transwell assays.

Results:

Total 218 and 121 circRNAs were differentially upregulated and downregulated, respectively; these were mainly enriched with GO and KEGG terms related to biological functions. From five representatives of the differentially expressed circRNAs, we selected hsa_circ_0085465 for further analysis, discovering that its overexpression promoted the proliferation, migration, and invasion of 97 L cells.

Conclusion:

Taken together, our results suggest that hsa_circ_0085465 is relevant to liver cancer progression.
Metastatic choriocarcinoma of the kidney in the absence of existing primary uterine tumor: A rare presentation
Authors: Pahwa Saloni , Sharma Anila , Kamboj Meenakshi , Gupta Gurudutt , Pasricha Sunil
Published: July 2023

Gestational choriocarcinomas are malignant neoplasms generally arising in the uterus in women of childbearing age. These are aggressive tumors with a high incidence of metastasis to vascular organs such as the lung, liver, and brain. Renal metastasis is extremely rare with low incidence rate and very few cases have been reported in literature. Hereby, we report a rare case of metastatic choriocarcinoma to the kidney in a 29-year-old female 10 years after resection of a hydatidiform mole. The histopathological diagnosis was made on a nephrectomy specimen. Pelvic and abdominal scan did not show any abnormal radiological findings. She was started on first-line chemotherapy and showed a complete response. In conclusion, gestational or primary nongestational choriocarcinomas should always be considered as a differential diagnosis in young females of reproductive age group presenting with flank abdominal pain, unexplained hematuria, and atypical renal tumor histology.
Cisplatin-based combination therapy for cancer
Authors: Minerva  , Bhat Amrita , Verma Sonali , Chander Gresh , Jamwal Rajeshwer Singh , Sharma Bhawani , Bhat Audesh , Katyal Taruna , Kumar Rakesh , Shah Ruchi
Published: July 2023

Cisplatin, that is, cis-diamminedichloroplatinum is a coordinate compound that is mainly preferred as prior treatment against several solid tumors and malignancies like ovaries, head and neck, testicular, and lung cancers because of its anticancer activity. Cisplatin binds at the N7 position of purine and forms adducts, leading to altered activity of DNA that triggers apoptosis. DNA damage is followed by several signaling pathways like induced oxidative stress, upregulated p53, mitogen-activated protein kinase (MAPK), and Jun N-terminal kinases (JNK) or Akt pathways along with induced apoptosis. Additionally, cisplatin treatment comes with few disadvantages such as toxic effects, that is, hepatotoxicity, cardiotoxicity, neurotoxicity, etc., and drug resistance. Furthermore, to overcome cisplatin resistance and toxicological effects, combination drug therapy has been considered. The aim of the review is to focus on the molecular mechanism of action of cisplatin and combination drug therapy to reduce the side effects in cancer therapy.
BRCA mutation carriers suffering from ovarian cancer as a model for treatment decision in higher lines – Place for platinum reinduction
Authors: Zikan Michal , Vecerova Livia , Dubova Olga , Sehnal Borek , Soukupova Jana
Published: July 2023

Context:

Ovarian carcinoma is a malignancy with the highest mortality among gynecological cancers. Mutations in BRCA1/2 genes are believed to be a favorable prognostic factor and that, in general, the biological behavior of ovarian cancer in BRCA-positive individuals differs from others. However, some clinically relevant issues (i.e., prediction of response to chemotherapy and treatment of platinum-resistant BRCA-positive patients) remain unclear.

Aims:

(1) The aim of this study was to examine the prevalence of germline BRCA mutations in unselected recurrent ovarian cancer patient population, (2) analyze whether biological behavior of BRCA-positive tumors differs from others, and (3) analyze the effect of platinum reinduction in platinum-resistant BRCA-positive patients.

Settings and Design:

This was a single-institution retrospective analysis.

Subjects and Methods:

Consecutive recurrent ovarian cancer patients from years 2012 to 2020 were included; their BRCA1/2 mutational status was analyzed and correlated with progression-free survival (PFS), type of treatment, and response to treatment.

Statistical Analysis Used:

Statistical significance of differences between and among patients was tested for continuous variables by the Mann–Whitney U-test or the Kruskal–Wallis test; a maximum likelihood Chi-square test was used for categorical variables.

Results:

Two hundred and forty-three recurrent ovarian cancer patients were included. The median follow-up was 37 months. Pathogenic mutation in BRCA1 or BRCA2 gene was found in 18.1% of patients. There was no difference in PFS comparing BRCA-positive to BRCA-negative patients (median PFS: 10.2 vs. 10.1 months, P = 0.874); there was a difference in PFS comparing BRCA-negative versus BRCA-positive platinum-sensitive patients (9.4 vs. 14.3 months, P = 0.002). BRCA-positive platinum-resistant patients reinduced with platinum achieved a median PFS of 8 months (compared to those receiving nonplatinum treatment, median PFS: 4 months, P = 0.062).

Conclusions:

Germline BRCA mutations are not exclusive to platinum-sensitive ovarian cancer patients; even in platinum-resistant patients, mutation can be detected. We found no difference in PFS for platinum-sensitive BRCA-positive and BRCA-negative patients. Platinum reinduction may be considered for BRCA-positive platinum-resistant ovarian cancer patients to prolong PFS. Even these data describe only a small population, it supports the clinical practice of platinum-based chemotherapy use in platinum-resistant BRCA-positive patients.
Clinical study evaluating the effectiveness and efficiency of metrohex plus gel and diode laser therapy along with standard mechanical debridement for managing chronic periodontitis
Authors: Singh Gaurav , Chauhan Shailendra S. , Sharma Satendra , Sinha Aditya , Kulshrestha Saksham
Published: July 2023

Aim

A study was carried out to determine how effective diode lasers and metrohex plus gel are at managing chronic periodontitis when compared to standard periodontal therapy.

Materials and methods

A total of 90 sites having periodontal probing depth more than or equal to 5 mm were included with patients aged around 35–60 years. Each group contains 30 sites as follows: group I laser-assisted new attachment procedure, group II metrohex plus gel, group III SRP alone.

Results

Based on the average GI value at baseline, 1 and 3 months, the values were 1.9 ± 0.67, 0.99 ± 0.26, and 0.89 ± 0.19, respectively. The mean PI* score decreased to 1.12 ± 0.31 at 1 month and 0.80 ± 0.31 at 3 months from 2.30 ± 0.58 at baseline. A periodontal probing depth reduction of 0.85 ± 0.03 mm was observed at 3 months for sites treated with laser, which was significantly higher than the reductions for sites treated with metrohex plus (metronidazole 10 mg + chlorhexidine gluconate 0.25% w/w and hyaluronic acid) and SRP alone. Periodontal probing depth reductions were not significantly different between groups I and II. Group II showed a 0.35 ± 0.11 mm improvement in clinical attachment level compared to group III.

Conclusion

As opposed to simple SRP, diode laser therapy and metrohex plus gel improve all clinical parameters in patients with periodontitis.
Reliable Ship Emergency Power Source: A Monte Carlo Simulation
Approach to Optimize Remaining Capacity Measurement Frequency for Lead-Acid
Battery Maintenance
Authors: Golovan Andrii , Gritsuk Igor , Honcharuk Iryna
Published: July 2023

The development of predictive maintenance has become one of the most important
drivers of innovation, not only in the maritime industry. The proliferation of
on-board and remote sensing and diagnostic systems is creating many new
opportunities to reduce maintenance costs and increase operational stability. By
predicting impending system faults and failures, proactive maintenance can be
initiated to prevent loss of seaworthiness or operability. The motivation of
this study is to optimize predictive maintenance in the maritime industry by
determining the minimum useful remaining lead-acid battery capacity measurement
frequency required to achieve cost-efficiency and desired prognostic performance
in a remaining battery capacity indication system. The research seeks to balance
operational stability and cost-effectiveness, providing valuable insight into
the practical considerations and potential benefits of predictive maintenance.
The methodology employed in this study includes outlining the theoretical
development of a fully automated condition monitoring system and describing data
cleansing steps to account for environmental effects on system performance. A
Monte Carlo simulation is used to evaluate the sensitivity of the remaining
useful life prediction to varying measurement frequencies, prediction models,
and parameter settings, leading to an estimate of the optimal measurement
frequency for the system. The results show that a certain minimum measurement
frequency is required to achieve the target prediction accuracy while balancing
cost-efficiency and operational stability. Reliable failure prediction with
negligible changes in prognostic accuracy can be achieved by performing useful
remaining lead-acid battery capacity measurements twice a day or every 5 ship
voyage cycles with the underlying utilization.
Problematic aspects in improving the training of medical personnel and their role in the surgical treatment of patients
Authors: Shabunin A. V. , Berseneva E. A. , Logvinov Yu. I. , Gorbunova E. A.
Published: July 2023

The article presents an analysis of the data of a sociological survey of medical workers conducted by the Research Institute of Health Organization and Medical Management of the Department of Health of the City of Moscow. Attention is focused on important aspects in the treatment of acute surgical diseases of the abdominal cavity and their connection with education in advanced training programs.
Comprehensive use of simulation equipment in teaching students of a medical profile
Authors: Galimov O. V. , Safin I. N. , Ziangirov R. A. , Khanov V. O. , Sufiyarov R. S.
Published: July 2023

To determine the factors that ensure successful and complete implementation of the proposed simulation and tasks, a “boxed” simulator was taken to work out bimanual manipulations and work skills with a needle-holder and Lapsim simulator. A computer simulator allows with a high level of reliability to work out the stages of surgical interventions, use anatomical situations of various levels of complexity, work out orientation skill in two -dimensional space, master the use of a video camera, and getting used to the “lever effect”. Two training groups (16–18 students) performed the proposed simulation exercises and tasks within 2 weeks. For the current academic year, 38 groups passed this course. In general, the successful and complete implementation of the proposed simulation and tasks was carried out mainly by those students who were motivated to study this subject, that is, who chose professional specialization related to surgery.
Explorando nuevas estrategias de formación del profesorado de matemáticas: un enfoque ampliado del Lesson Study para el desarrollo profesional en la Escuela Andorrana
Authors: Rodríguez Muñiz Luis J. , Aguilar-González Álvaro , Alonso-Castaño Marlén , García-Honrado Itziar , Lorenzo-Fernández Esther , Muñiz-Rodríguez Laura
Published: July 2023

El resumen en español en letra Cambria, 10 puntos. Tendrá
En este trabajo se presenta un programa de formación en acción para el profesorado de matemáticas de los cursos 5 y 6 (10-12 años) de la Escuela Andorrana adaptando el lesson study para poder implementarlo a gran escala. El programa, Andorran Lesson Study (ALS) permitió superar limitaciones mediante la grabación y el visionado masivo de vídeos de clase, junto con sesiones de discusión previa y posterior. La combinación de observaciones y respuestas del profesorado evidenció una contribución significativa del ALS al desarrollo profesional en la enseñanza de las matemáticas, mediante un progreso notable en el aprovechamiento de oportunidades de aprendizaje, un catálogo más amplio de representaciones y la comunicación efectiva sobre y en torno a las matemáticas. El ALS contribuyó a mejorar la eficacia en el desarrollo de las competencias matemáticas promovidas por el currículo andorrano. En conclusión, el ALS se presenta como una alternativa viable para la formación continua del profesorado, permitiendo una adaptación logística y cultural a diferentes contextos escolares y organizaciones