bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing germline TP53 mutations in cancer patients: insights into Li-Fraumeni syndrome and genetic testing guidelines
Authors: Danishevich Anastasiia , Fedorova Daria , Bodunova Natalia , Makarova Maria , Byakhova Maria , Semenova Anna , Galkin Vsevolod , Litvinova Maria , Nikolaev Sergey , Efimova Irina , Osinin Pavel , Lisitsa Tatyana , Khakhina Anastasiya , Shipulin German , Nasedkina Tatiana , Shumilova Syuykum , Gusev Oleg , Bilyalov Airat , Shagimardanova Elena , Shigapova Leyla , Nemtsova Marina , Sagaydak Olesya , Woroncow Mary , Gadzhieva Saida , Khatkov Igor
Published: February 2025

Background

Germline TP53 gene variants are intricately linked to Li-Fraumeni syndrome, a rare and aggressive hereditary cancer syndrome. This study investigated the frequency and spectrum of TP53 pathogenic variants associated with Li-Fraumeni syndrome in a large cohort of mainly breast cancer patients from Russia.

Methods

The study analyzed 3,455 genomic DNA samples from cancer patients using next-generation sequencing panels and whole-genome sequencing. Clinically significant TP53 variants were identified and validated using Sanger sequencing. The clinical and family history characteristics of patients with TP53 variants were analyzed.

Results

The analysis identified 13 (0.4%) individuals with clinically significant germline TP53 variants, all of whom were females with either unilateral breast cancer or breast cancer as part of multiple primary malignant neoplasms. The average age of breast cancer manifestation was 39.9 years, with a median of 36 years. Only 38.5% of the TP53 mutation carriers met the modified Chompret criteria for TP53 testing.

Conclusions

The findings underscore the necessity of thorough phenotype and family history analysis in genetic counseling to effectively diagnose LFS, and emphasize the importance of identifying TP53 variant carriers for developing treatment strategies, prognosis, and monitoring, as well as for identifying high-risk family members. The study also highlights that the current guidelines fail to identify over half of the TP53 mutation carriers, suggesting the need for a more comprehensive approach to genetic testing in suspected hereditary cancer cases.
Super-resolution synthetic MRI using deep learning reconstruction for accurate diagnosis of knee osteoarthritis
Authors: Wang Kejun , Liu Weiyin Vivian , Yang Renjie , Li Liang , Lu Xuefang , Lei Haoran , Jiang Jiawei , Zha Yunfei
Published: February 2025

Objective

To assess the accuracy of deep learning reconstruction (DLR) technique on synthetic MRI (SyMRI) including T2 measurements and diagnostic performance of DLR synthetic MRI (SyMRIDL) in patients with knee osteoarthritis (KOA) using conventional MRI as standard reference.

Materials and methods

This prospective study recruited 36 volunteers and 70 patients with suspected KOA from May to October 2023. DLR and non-DLR synthetic T2 measurements (T2-SyMRIDL, T2-SyMRI) for phantom and in vivo knee cartilage were compared with multi-echo fast-spin-echo (MESE) sequence acquired standard T2 values (T2MESE). The inter-reader agreement on qualitative evaluation of SyMRIDL and the positive percent agreement (PPA) and negative percentage agreement (NPA) were analyzed using routine images as standard diagnosis.

Results

DLR significantly narrowed the quantitative differences between T2-SyMRIDL and T2MESE for 0.8 ms with 95% LOA [−5.5, 7.1]. The subjective assessment between DLR synthetic MR images and conventional MRI was comparable (all p > 0.05); Inter-reader agreement for SyMRIDL and conventional MRI was substantial to almost perfect with values between 0.62 and 0.88. SyMRIDL MOAKS had substantial inter-reader agreement and high PPA/NPA values (95%/99%) using conventional MRI as standard reference. Moreover, T2-SyMRIDL measurements instead of non-DLR ones significantly differentiated normal-appearing from injury-visible cartilages.

Conclusion

DLR synthetic knee MRI provided both weighted images for clinical diagnosis and accurate T2 measurements for more confidently identifying early cartilage degeneration from normal-appearing cartilages.

Critical relevance statement

One-acquisition synthetic MRI based on deep learning reconstruction provided an accurate quantitative T2 map and morphologic images in relatively short scan time for more confidently identifying early cartilage degeneration from normal-appearing cartilages compared to the conventional morphologic knee sequences.

Key Points

Deep learning reconstruction (DLR) synthetic knee cartilage T2 values showed no difference from conventional ones.

DLR synthetic T1-, proton density-, STIR-weighted images had high positive percent agreement and negative percentage agreement using MRI OA Knee Score features.

DLR synthetic T2 measurements could identify early cartilage degeneration from normal-appearing ones.

Graphical Abstract
Charting a sustainable future in radiology: evaluating radiologists’ knowledge, attitudes, and practices toward environmental responsibility
Authors: Abuzaid Mohamed M. , Almuqbil Nora
Published: February 2025

Objectives

This study assesses radiologists’ knowledge, attitudes, and practices regarding healthcare sustainability. With radiology’s substantial environmental impact, sustainable practices are crucial to reduce energy use, waste, and resource depletion. The study evaluates radiologists’ awareness, engagement, and perceived barriers to sustainable practices in the UAE, identifying areas for improvement and intervention.

Methods

A cross-sectional survey was conducted among UAE radiologists in hospitals, clinics, and medical centers from August to October 2024. Developed and piloted by the research team, the survey addressed demographic details, sustainability knowledge, attitudes, current practices, and implementation barriers. Convenience sampling yielded 111 responses, analyzed using descriptive and inferential statistics to identify trends and associations.

Results

The findings indicate moderate knowledge levels, with 31.8% of radiologists agreeing to understand sustainability concepts. While 36.4% strongly agreed on its importance, only 20% felt it was prioritized at their workplace. Key barriers included lack of training (40.5% agreed, 29.7% strongly agreed) and insufficient financial support (37.8% agreed, 25.2% strongly agreed). Digital documentation and waste-reduction practices were observed but varied in consistency.

Conclusion

Radiologists display a positive attitude toward sustainability but face significant implementation barriers, primarily in institutional support and resources. Addressing training gaps and increasing leadership commitment are essential to advancing sustainable practices. Future initiatives should emphasize policy support, education, and resource allocation to foster a sustainable radiology sector.

Critical relevance statement

This article critically examines radiologists’ knowledge, attitudes, and barriers to sustainable practices, highlighting the need for institutional support and targeted training to advance environmental responsibility and sustainable practices within clinical radiology.

Key Points

Radiologists support sustainability but lack knowledge of specific practices.

Key challenges include limited training, support, and funding.

Commitment, training, and resources are essential for sustainable radiology.

Graphical Abstract
CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury
Authors: Fu Jiayuanyuan , Du Mengran , Wu Biying , Wu Chenrui , Li Xin , Tan Weilin , Huang Xuekang , Zhu Ziyu , Zhang Jie , Liao Zheng Bu
Published: February 2025

Sleep disorders (SD) are common sequelae following traumatic brain injury (TBI) and may be linked to mitochondrial oxidative stress dysregulation after TBI. Increasing evidence showed that circRNAs play crucial roles in nervous system diseases. However, the involvement of circRNAs in sleep disturbances after TBI is not characterized. In this study, differentially expressed circRNAs were identified by RNA sequencing. Sleep quality in TBI patients was assessed through sleep scales and electroencephalograms. Further experiments were conducted to investigate the role of circItm2b. We found that circItm2b was elevated and involved sleep disorder in TBI patients. Over-expression of circItm2b might aggravate sleep disturbances in mice after TBI. Mechanically, circItm2b regulates Nox4 expression through binding Sirt1, which influences mitochondrial oxidative stress-caused circadian protein losses. Moreover, the knockdown of circItm2b attenuated mitochondrial oxidative stress-induced circadian proteins losses via circItm2b/Sirt1/Nox4 axis after TBI, which might suggest that circItm2b may serve as a prognostic marker for improving sleep disorders and represent a promising therapeutic target for TBI-related sleep disturbances.
Exploring apathy components and their relationship in cognitive decline: insights from a network cross-sectional study
Authors: Sarti Pierfrancesco , Varrasi Simone , Guerrera Claudia Savia , Platania Giuseppe Alessio , Furneri Giovanna , Torre Vittoria , Boccaccio Francesco Maria , Rivi Veronica , Tascedda Sophie , Pirrone Concetta , Santagati Mario , Blom Johanna M. C. , Castellano Sabrina , Caraci Filippo
Published: February 2025

Background

Apathy worsens with age and cognitive decline, particularly in Alzheimer’s, leading to functional and cognitive deterioration. Comprehending its broad impact is vital for customized, preventive treatments.

Methods

The study examined 214 adults divided in three groups—Mild Cognitive Impairment, mild Alzheimer’s, and controls—using neuropsychological tests and questionnaires, with statistical and network analysis to explore apathy’s links with other group variables related to demographics and treatment.

Results

Notable differences were observed among the groups' performance of administered tests. While inferential statistics failed to return a predictive model of apathy in mild Alzheimer’s, networks and cluster analyses indicate that the demographic variables analysed have different importance at different times of disease progression and that cognitive apathy is particularly prominent in AD-related decline.

Conclusions

Network analysis revealed insights into dementia risk differentiation, notably the impact of sex and demographic factors, beyond the scope of traditional statistics. It highlighted cognitive apathy as a key area for personalized intervention strategies more than behavioural and emotional, emphasizing the importance of short-term goals and not taking away the person's autonomy when not strictly necessary.
Detailed inventory and initial analysis of landslides triggered by extreme rainfall in the northern Huaiji County, Guangdong Province, China, from June 6 to 9, 2020
Authors: Xie Chenchen , Xu Chong , Huang Yuandong , Liu Jielin , Jin Jiale , Xu Xiwei , Cheng Jia , Wu Lizhou
Published: February 2025

Background

In recent years, the frequency of extreme rainfall events has increased due to climate change, further raising the probability of landslide disasters. From June 6 to 9, 2020, the northern part of Huaiji County, Guangdong Province, and surrounding areas experienced extreme rainfall. By using high-resolution optical remote sensing images before and after the rainfall and interactive human–machine recognition technology, a detailed list of landslides from this extreme rainfall event was established and preliminarily analyzed.

Results

A total of 5173 landslides were triggered by this rainfall event, covering an area of 13.27 km2, mainly concentrated in the central part of the study area. The maximum point density and area density of the landslide list were 60.71 km−2 and 19.11%, showing a high degree of overlap. The relationship between landslide area and quantity, area and probability density showed a good power-law relationship, confirming the completeness of the landslide list. By combining common landslide abundance indicators, the correlation between landslides and five influencing factors including elevation, slope, aspect, strata, and cumulative rainfall was analyzed.

Conclusion

This study supplemented rainfall-induced landslide data in the southeastern coastal region of China, aiding in the analysis of landslide occurrence patterns, landslide risk assessment, and providing a basis for warning and emergency response for local governments and relevant departments.
The impact of sociocultural theory-informed instruction on learners’ IELTS writing: task response, grammar, vocabulary, coherence and cohesion
Authors: Allami Hamid , Najari Boshra , Tajeddin Zia
Published: February 2025

This study explores the impact of sociocultural theory-based instruction on enhancing L2 learners’ writing skills including grammatical accuracy, coherence, cohesion, task response, and lexical resources for the IELTS. To this end, a cohort of 40 participants, spanning intermediate and advanced proficiency levels, was divided into experimental and control groups, each comprising 20 students. The research utilized the Oxford Placement Test to ensure a balanced distribution. Throughout the instructional period, learners actively participated in collaborative group activities and benefited from scaffolding techniques. The analysis of outcomes revealed the effectiveness of sociocultural strategies, leading to significant progress across different proficiency levels. While intermediate participants demonstrated marked improvements in task response, advanced learners exhibited heightened levels of coherence and cohesion in their writing. The findings indicate the paramount importance of employing scaffolding and collaborative methodologies to foster writing proficiency, particularly in the context of preparing for the IELTS. This research sheds light on the potential of sociocultural theory-based instruction to positively influence second language learners' writing abilities.
Comparative performance of PROMIS Sleep Disturbance computerized adaptive testing algorithms and static short form in postmenopausal women
Authors: Trigg Andrew , Haberland Claudia , Shalhoub Huda , Gerlinger Christoph , Seitz Christian
Published: February 2025

Background

The Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance v1.0 item bank (27 items) measures sleep disturbances. Rather than the full item bank, an 8-item short form (PROMIS SD SF 8b) or computerized adaptive testing (CAT) can be used. This study compares the performance of the PROMIS SD SF 8b with two CAT algorithms in postmenopausal women.

Methods

This is a secondary analysis of data collected for the original psychometric testing of the PROMIS Sleep Disturbance item bank, in a sub-sample of women aged ≥55. A graded response model (GRM) was fitted for the item bank, then simulations evaluated the performance of CAT algorithms and the short form, in terms of root mean square error (RMSE) versus the latent trait estimate derived from the full bank. Two CAT algorithms were tested: CAT1 (stop once standard error <0.3 or 12 items administered) and CAT2 (stop once 8 items administered). Convergent and divergent hypotheses for validity were tested through correlations with the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). Known-groups comparisons were made between those with and without self-reported sleep disorder.

Results

A sample of 337 women was analyzed. Unidimensionality and item-level fit to the GRM was supported; however, the local independence assumption was violated. The CAT1 algorithm showed 4.18 items on average, with a minor decrease in performance (higher RMSE value) compared to CAT2 or the PROMIS SD SF 8b. Administering 8 items adaptively (CAT2) compared to fixed (PROMIS SD SF 8b) performed similarly (RMSE difference = 0.001). Reliability exceeded 0.90 across most of the latent trait for all approaches. Correlations with the PSQI and ESS were largely as hypothesized, with minor differences in coefficient values between the approaches (all within 0.05). Women reporting a sleep disorder had greater sleep disturbance than those who did not (p < 0.001 for all).

Conclusions

The results of this study support using the PROMIS Sleep Disturbance item bank in postmenopausal women. The choice of PROMIS SD SF 8b versus CAT can largely be driven by practical reasons (respondent burden and operational complexity) rather than concerns of differential reliability and validity.
Research focus and theme trend on Charcot–Marie–Tooth disease since 2000: a bibliometric analysis
Authors: Dai Shimiao , Zhu Junying , Yang Aolin , Li Yao , Ma Miaomiao , Lv Qingqing , Chen Yuqing , Sun Litao , Zhou Ji-Chang
Published: February 2025

Background

Charcot–Marie–Tooth disease (CMT) represents a hereditary neuromuscular disorder characterized by an incomplete pathological understanding and a lack of effective therapeutic interventions. This study aimed to investigate the advancement of CMT research, anticipate its developmental trajectory, and offer insights for development endeavors.

Results

Bibliometric data of articles published from January 2000 to December 2023 were downloaded from five databases: Scopus, Embase, Web of Science, and PubMed. The study retrieved 5,053 articles. The United States has emerged as the most productive country and maintained the most robust cooperation with other countries on CMT research. Following a clustering analysis, 124 high-frequency keywords were categorized into three clusters, further subdivided into seven specific themes: cell and animal model studies, associated protein, neurological studies, epidemiological distribution, disease diagnosis, clinical feature, and genetic analysis. The strategic diagram highlights genetic analysis emerges as a prospective focus.

Conclusions

CMT genetic analysis, which encompasses novel gene identification, therapy oriented toward molecular genetics, and the synergistic influence of multiple genes, are expected to be the prospective hotspots and potential trends in the CMT research field.
Optimization of phosphorus leaching from sludge of rubber-latex processing wastewater-treatment plant in Vietnam
Authors: Dinh Khang Vu , Le Hung Anh , Pfennig Andreas
Published: February 2025

In this study, optimal parameters for P leaching from sludges of a rubber-latex processing wastewater-treatment plant were carried out. The process optimization is based on laboratory experiments and simulation with a MATLAB program. The optimal P-leaching parameters for dried sludges were found to be as follows: dried sludge particle size below 2.5 mm, leaching time of 60 min, a phase ratio of 10 mL g−1 with 2 M H2SO4 for chemical sludge, a phase ratio of 5 mL g−1 with 1.7 M H2SO4 for biological sludge. At these conditions, P leaching efficiency reaches 90% on average for chemical as well as biological sludge. The equilibrium pH of the leached liquid was found to affect formation of mineral precipitates, such as gypsum (CaSO4), which leads to significant reduction in the dissolved Ca content in the leached liquid. Simulation results from the solid–liquid-liquid thermodynamic equilibrium tool also show the formation of other precipitated minerals such as AlPO4, FePO4, or Al(OH)3 at different equilibrium pH. The highest dissolved P and lowest dissolved Ca contents were observed at equilibrium pH less than 0.3.
A bibliometric analysis of the 50 most cited articles about quality of life in patients with atrial fibrillation
Authors: Hassan Muhammad Arslan Ul , Mushtaq Sana , Li Tao , Yang Zhen
Published: February 2025

Background

Atrial fibrillation is a progressive arrhythmia that has become a global concern affecting the quality of life of millions of patients. This bibliometric analysis aims to highlight the top 50 most cited articles in the field of quality of life in atrial fibrillation patients, focusing on publication trends, citations, influential authors and journals, promising institutions, and key contributing countries.

Results

The top 50 articles were published between 1995 and 2021 across 15 journals, with an average number of citations of 380.5 per article. The article with the highest number of citations, i.e., 1525, was published in the ‘Circulation’ journal. ‘Natale Andrea’ and ‘Verma Atul’ contributed the most to the field, with 7 articles each. The United States of America had the highest total number of publications among the countries, with 20 articles. The field is extensively researched; however, there remains a necessity for methodological enhancements in the assessment of quality of life.

Conclusions

This study assessed advancements in research regarding quality of life in atrial fibrillation patients and serves as an invaluable resource for clinicians and researchers to comprehend the existing body of knowledge in the field. Although quality of life in patients with atrial fibrillation has been the focus of interest in recent years, the management of patients still needs improvement.
Unraveling the Depths: Serpentinite Distribution and Hydrogen Potential in the Subduction Zones of NW South America
Authors: Vargas Carlos Alberto , Caneva Alexander , Zuluaga Carlos Augusto
Published: February 2025

Serpentine bodies, primarily formed through the hydration of mafic and ultramafic rocks, exhibit distinctive geophysical properties in the convergent margin of NW South America. This region features a complex subduction zone that includes a suture zone and a lithospheric tear, which control serpentinite outcrops' distribution and depth geometry. By analyzing gravity and magnetic anomalies, geothermal data, Vp/Vs ratio tomography, and magnetotelluric and gas measurements, we investigated the subsurface connections of serpentinite bodies, particularly within the Romeral Suture Zone (RSZ) and the Eastern Cordillera of Colombia. The main findings indicate that serpentinite occurrences are associated with specific geophysical anomalies and seismicity patterns, highlighting their role in subduction dynamics. Vp/Vs ratio tomography and space-time variations of apparent resistivity reveal deeper serpentinite diapirism on both sides of the volcanic arc, likely linked to buoyant advection from the subducted plates, affecting magmatism and earthquake distribution. The Caldas Tear could respond to the subduction geometry and the distribution of serpentinites, suggesting an interaction between tectonic processes and serpentinization. These insights enhance the understanding of subduction zone mechanics and the potential for natural hydrogen generation in serpentinized rocks, contributing to the broader knowledge of geotectonic evolution and renewable energy resource potential in subduction environments.
Fluctuations of topological charges in two-dimensional classical Heisenberg model
Authors: Tang Shan-Chang , Shi Yu
Published: February 2025

Binding and unbinding of vortices drives Kosterlitz-Thouless phase transition in two-dimensional XY model. Here we investigate whether similar mechanism works in two-dimensional Heisenberg model, by using the fluctuation of the topological charge inside a loop to characterize the nature of binding versus unbinding of defects. Through Monte Carlo simulations, we find that the fluctuation is proportional to the perimeter of the loop at low temperatures while to the area of the loop at high temperatures, implying binding of the defects at low temperatures and unbinding at high temperatures.
Medullary Thyroid Carcinoma and Clinical Outcomes in Heterozygous Carriers of the RET K666N Germline Pathogenic Variant
Authors: Yip Allison T , Kim Teresa H , Peluso Esther M , Jacobsen Steven E , Yeh Michael W , Lechner Melissa G
Published: February 2025

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor of the thyroid parafollicular C-cells associated with activating mutations in the rearranged during transfection (RET) kinase proto-oncogene. We report the clinical outcomes of a family with a rare germline RET K666N pathogenic variant discovered incidentally by genetic testing performed for breast cancer risk stratification in an asymptomatic 24-year-old woman. Subsequent genetic testing identified the same pathogenic variant in her 21-year-old sister, 60-year-old father, and 84-year-old paternal grandmother. The proband and her sister had no biochemical or imaging evidence of MTC. The 60-year-old father had mildly elevated serum calcitonin and multiple thyroid nodules on ultrasound. Fine-needle aspirate thyroid biopsy cytology suggested MTC so he underwent total thyroidectomy. Surgical pathology demonstrated bilateral subcentimeter foci of MTC and C-cell hyperplasia. The 84-year-old grandmother was also found to have multiple thyroid nodules and elevated calcitonin but declined further evaluation. There was no biochemical evidence of other multiple endocrine neoplastic type 2 (MEN2)-associated tumors (ie, parathyroid adenoma, pheochromocytoma) in the family. These data, along with prior rare reports in the literature, suggest that monoallelic germline RET K666N pathogenic variants carry a risk of familial MTC that demonstrate age-dependent expressivity but low penetrance of other MEN2 tumors in affected individuals.
An Unusual Cause of Hypokalemia to Consider
Authors: Borrego-Soriano Inés , Hernández-Perdomo Yanieli , Rivas Begoña , Parra-Ramírez Paola , Moreno-Domínguez Óscar , Vega-Cabrera Cristina
Published: February 2025

Apparent mineralocorticoid excess syndrome is a rare disorder that can be acquired through inhibition of the enzyme 11 β-hydroxysteroid dehydrogenase type 2 by various substances such as bile acids. We report the case of a 61-year-old woman presenting with painless jaundice. Computed tomography demonstrated a pulmonary as well as a pancreatic tumor, with multiple metastases and dilated bile ducts. Laboratory findings showed persistent hypokalemia despite aggressive enteral and parenteral supplementation, as well as hypertension, metabolic alkalosis, and elevated cholestasis enzymes. Urinary potassium excretion was inappropriately high. Plasma aldosterone concentration was 0.97 ng/dL (26.91 pmol/L) (reference range, 2.21-25.30 ng/dL [61.31-701.82 pmol/L]) and direct renin concentration was 3.9 mIU/L (2.1 ng/L) (reference range, 4.4-46.1 mIU/L [2.53-27.42 ng/L]). Endogenous hypercortisolism was ruled out. After the placement of a metal biliary stent via endoscopic retrograde cholangiopancreatography and the subsequent decrease in cholestasis enzyme levels, potassium levels, hypertension, and metabolic alkalosis gradually normalized. The case was ultimately diagnosed as apparent mineralocorticoid excess syndrome resulting from 11 β-hydroxysteroid dehydrogenase type 2 inhibition caused by elevated bile acids secondary to malignant obstruction of the biliary tract.
Το θέατρο στα Γιάννενα:
Authors: Τέλη Αγαθή
Published: February 2025

Σκοπός της παρούσας μελέτης, είναι να διερευνηθεί ο ρόλος του θεάτρου στην Ήπειρο, η ιστορική του εξέλιξη και η συμβολή του στην συγκρότηση της καλλιτεχνικής και πνευματικής ζωής της περιοχής, το δεύτερο μισό του 20 ου αιώνα. Πιο συγκεκριμένα δεν επιχειρήσαμε μια απλή καταγραφή των θεατρικών παραστάσεων, που έλαβαν χώρα σε συγκεκριμένο χρόνο (Β ̔μισό του 20ου αιώνα) και τόπο (Ήπειρος) αλλά επιχειρήσαμε να ανιχνεύσουμε, μέσα από την πρόσληψη του θεατρικού φαινομένου, την διαμόρφωση νοοτροπιών, συνηθειών και εν γενεί στάσεων ζωής, που μεταμορφώνονται μέσα από την επαφή τους, με την τέχνη του θεάτρου. Η πρότασή μας, εντάσσεται κατά τη γνώμη μας, σε τρία (3) επιστημονικά πεδία : αυτό της Πολιτισμικής Ιστορίας, της Τοπικής Ιστορίας και της Θεατρολογίας. Οι άξονες που θα κινηθούμε, θα μας βοηθήσουν να κατανοήσουμε : α) πώς το θέατρο αντιμετωπίστηκε από την τοπική κοινωνία και β) πώς συνέβαλλε στην διαμόρφωση των τοπικών πολιτισμικών πρακτικών. Θα προσπαθήσουμε να διερευνήσουμε κατά πόσο επηρεάζει και επηρεάζεται η θεατρική δραστηριότητα από τη σταδιακή αστικοποίηση που συντελείται στην πόλη των Ιωαννίνων και πώς αυτή βοηθά στην συγκρότηση μιας νέας θεατρικής κουλτούρας, η οποία αποτυπώνεται στις συνήθειες και τις προσδοκίες των ανθρώπων, οι οποίοι αναλαμβάνουν πρωτοβουλίες για τη δημιουργία ενός δικού τους τοπικού, περιφερειακού θεάτρου, καθώς η αντίληψη του ρόλου του θεάτρου αποκτά με τον καιρό βαρύνουσα και πολυεπίπεδη σημασία: ψυχαγωγική, δημιουργική, εκπαιδευτική, κοινωνική.
Case Report: Superotemporal branch retinal vein occlusion following COVID-19 vaccination and SARS-CoV-2 infection while taking oral contraceptives
Authors: Muto Tetsuya , Sakamoto Masaaki , Machida Shigeki , Imaizumi Shinichiro , Hamada Yoshinobu , Kamoi Koju
Published: February 2025

Oral contraceptive use, vaccination for Coronavirus disease 2019 (COVID-19), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are risk factors for venous thromboembolism. Branch retinal vein occlusion (BRVO) generally develops mid-60s patients. Herein, we present a case of superotemporal BRVO caused by the above mentioned risk factors in a young woman. To the best of our knowledge, this is the first report about superotemporal BRVO associated with oral contraceptives, COVID-19 vaccination, and SARS-CoV-2. A 21-year-old woman presented with loss of visual acuity in her right eye for 10 days. She had been receiving oral contraceptives for 2 years for oligomenorrhea before noticing ophthalmological symptoms. Despite having received two doses of an mRNA COVID-19 vaccine, she contracted COVID-19 and developed fever, sore throat, cough, low back pain, and general malaise about 40 days before the initial visit. However, only cough persisted for more than a month. The right eye showed superotemporal BRVO with macular edema (ME). She did not smoke nor had diabetes or hypertension. Blood test results, including cardiolipin antibody IgG, were normal. She was treated with an intravitreal aflibercept injection. ME in the fundus showed rapid improvement and resolution. Although more than 20 months have passed since the first injection, there has been no relapse of ME. The combination of oral contraceptive use, COVID-19 vaccination, and subsequent SARS-CoV-2 infection could induce the development of venous thromboembolism, thereby leading to superotemporal BRVO. Given that cases of COVID-19 have increased globally, patients with retinal vein occlusion who use oral contraceptives are likely to be encountered more frequently.
El declive del dinero en efectivo: perspectivas y desafíos.
Authors: Bujalance-Rey Susana , Trillo-Holgado María Amalia
Published: February 2025

Este estudio analiza la posible extinción del dinero físico de la economía y su repercusión, hecho que se ha acelerado a raíz de la pandemia del COVID-19. Se enfoca
específicamente en las relaciones que las PYMES españolas establecen con sus clientes, instituciones bancarias u otros agentes del entorno, planteando posibles escenarios a futuro para facilitar la gestión sostenible de su actividad. Metodológicamente
se lleva cabo un estudio de casos analítico, contemporáneo y múltiple con alcance
genérico basado en empresas integradas en sectores representativos. Se concluye
que España tiene aún un largo camino por recorrer tanto en lo económico como en
lo político y social, ya que el efectivo sigue desempeñando un papel crucial en su
economía.
The effects of urban housing policies socio-spatial distance on families with different paths in Adrar neighborhood of Agadir.
Authors: Assebane Mohamed
Published: February 2025

The study aimed to analyze and understand the problem of social-spatial distance “in
their intricacies and complex intersections to the issue of urban integration” (Elbhiri
& Assebane, 2022) between two typologies of families with different paths. The first
model refers to families that fall within the framework of the settlement policy,
residents of shanty houses. The second model relates to families not targeted by the
housing policy and who broke into the housing market due to their economic capital
by purchasing the rights of slum residents within the neighborhood. According to
the gender approach, the study’s sample consisted of twelve people; there were six
males and six females. The qualitative methodology employed in the study included
observation and semi-directed interviews. As a result, this study came to several
conclusions. For instance, the families who weren’t covered by the resettlement
program had no issues with the distance between the housing sites and the work
locations. For the families covered by the resettlement policy, the distance between
their place of residence and place of employment presents daily challenges because
they don’t have access to private transportation, except for one respondent who
owns a motorcycle.
Recurrent acute pancreatitis and primary hyperparathyroidism in patients presenting to the emergency department: Diagnostic challenges
Authors: Danış Faruk , Kudu Emre
Published: February 2025

We read the article by Karim MM et al discusses the presentation of primary hyperparathyroidism as recurrent acute pancreatitis, a rare clinical condition in pediatric patients presenting to the emergency department. As emergency medicine clinicians, we frequently encounter diverse and complex cases, and such rare conditions pose significant challenges in the diagnostic process. This article will discuss the management and diagnostic approach of such cases encountered in the emergency department.
Thermal-compensated high-stability, high-repetition-rate electro-optic Q-switched Nd:YAG laser and its application in MIR generation
Authors: Sun Yue , Xu Degang , Zhao Yuantao , Li Zhenzuo , Wang Yuye , Chen Kai , Yao Jiyong , Zhong Kai , Li Jining , Yao Jianquan
Published: February 2025

In this paper, a high-stability, high-pulse-energy 1064 nm electro-optic (EO) Q-switched laser at a repetition rate of 1 kHz has been demonstrated. The thermal lensing of composite Nd:YAG crystal was theoretically analyzed based on the simulation of the temperature distribution process. A thermally-compensated flat-convex laser cavity was developed to increase laser mode volume. The maximum single pulse energy of 9.1 mJ with a pulse width of 11.4 ns was achieved under the average pump power of 40 W, corresponding to the peak power of 0.8 MW and the slope efficiency of up to 40.4%. Besides, the pulse timing jitter was less than 600 ps, and the energy fluctuation in 40 minutes was about 0.09%. Based on a BaGa4Se7 optical parametric oscillator (BGSe-OPO), the average power of 564 mW with a pulse width of 9.8 ns was achieved at 3.88 µm. Moreover, a wide tuning range of 3.0-5.04 µm was obtained by crystal angle tuning method. This compact laser system is a promising laser source for remote sensing and jamming.
Laser ultrasonic inspection of subsurface defects at high temperature using mode-converted surface wave
Authors: Zeng Yike , Zhao Gaozheng , Jin Haoran , Yang Keji , Chen Jian
Published: February 2025

Subsurface defects are detrimental to the safety and integrity of critical components, particularly for those used in high-temperature environments. A reliable non-destructive evaluation method for in-situ inspection of subsurface defects in high-temperature components is highly desired. Laser ultrasonic techniques favorably accommodate the demands by virtue of non-contact generation and detection of surface waves. In this work, laser ultrasonic inspection of subsurface defects in high-temperature components is proposed, exploiting the mode-converted surface wave from skimming longitudinal waves as a distinctive signature for the rapid recognition of subsurface defects. Wave transition is numerically revealed with finite element simulation, from which the phenomenon of wave mode conversion is readily identified. Meanwhile, the dependence of surface wave velocity on temperature is established to adaptively compensate the velocity variation at high temperatures. Thereafter, delay-and-sum method is used to constructively enhance the signal-to-noise ratio of the mode-converted waves. A scanning laser ultrasonic setup is built to experimentally verify the feasibility and effectiveness of proposed method on the inspection of subsurface defects at different temperatures. Collectively, this work offers a viable route for in-situ inspection of subsurface defects in high-temperature components, where conventional ultrasonic methods fail. This approach has potential applications in broad fields, such as coating quality evaluation during fabrication, bearing assessment under load, and in-situ monitoring for additive manufacturing.
16-band single-photon imaging sensor based on Fabry-Perot resonance
Authors: Zhou Chufan , Martin Olivier J. F. , Charbon Edoardo
Published: February 2025

We have demonstrated a 16 wavelength selective spectral bands imaging sensor-based Fabry-Perot (FP) structure for use in the near-infrared wavelength band (715 nm-915 nm). The designed structure consists of two symmetric SiC/SiO2 distributed Bragg reflector (DBR) multilayer structures that sandwich a SiO2 interval layer. We tuned the thickness of the SiO2 interval layer to achieve wavelength selectivity and tunability. Fabrication and measurement results based on the FP structure show high resolution and good uniformity. Furthermore, for the first time, we combined the ultra-narrow band FP filter with single photon avalanche diode (SPAD). Finally, a category algorithm to reconstruct the narrow-band filter and improve the cross-talk caused by the overlap of the FP curve is proposed. The combination of FP hyper-spectral filter with SPAD opens the door to several novel applications.
Broadband OAM vortex beams generating through transmitarray for millimeter wave applications
Authors: Hayat Babar , Zhang Jinling , Ishfaq Muhammad , Ahmad Shabeer , Khan Adil , Majeed Abdul
Published: February 2025

In this paper, we propose a wideband transmitting metasurface to generate orbital angular momentum (OAM) vortex beams for millimeter-wave communication applications, such as advanced wireless systems and 5G/6G networks. Our proposed element comprises four dielectric layers and four conductor layers, with a separation between layers set at 0.2 mm and the thickness throughout of 2.6 mm (0.26λ0 at 30.0 GHz). The symmetrical arrangement and identical layers of the unit cell facilitate its usage in scenarios involving both polarization. We fabricate and test our proposed metasurface for OAM modes with l = +1 and l = +2 to validate its simulation performances. Experimental findings confirm that the proposed designs effectively achieve broad-frequency performance for vortex beams in both modes. The overall mode purity exceeds 85% for l = +1 and 75% for l = +2 across the sweep of frequencies ranging from 25.0 to 35.0 GHz, representing approximately 33.3% of the OAM bandwidth. Additionally, we achieve a maximum gain of 22.8 dBi for l = +1 and 21.1 dBi for l = +2 with aperture efficiencies of 15.1% and 10.2%, respectively.
Generation of stable 172 nJ, 95 fs pulses from a cavity-dumped direct-diode pumped Ti:sapphire laser
Authors: Kim Su Youn , Seo Hong-Seok , Kim Hyungwoo , Ko Do-Kyeong , Song Dong Hoon
Published: February 2025

We demonstrate a diode-pumped Ti:sapphire laser capable of producing high-energy femtosecond pulses via cavity dumping. Four spectrally combined diodes were used to pump the Ti:sapphire laser directly, which was mode-locked using a semiconductor saturable absorber mirror. At a repetition rate of 100 kHz using a cavity dumper, 172 nJ and 95 fs pulses were generated, corresponding to a pulse peak power of 1.8 MW. The signal-to-noise ratio at the 100 kHz dumped frequency exhibited an extinction ratio exceeding 55 dB relative to the carrier. To the best of the authors’ knowledge, this is the highest pulse energy obtained using a direct diode-pumped Ti:sapphire laser.
Electron noise analysis of Wolter-I X-ray telescope based on Monte Carlo simulation
Authors: li linsen , zeng jun , qiang pengfei
Published: February 2025

To investigate bremsstrahlung radiation generated when the multi-layer nested Wolter-I X-ray telescope is bombarded by a high-energy electron stream,A simulation analysis using Monte Carlo simulation software MCNP was performed to study this process(The mirror reflective film material:Ir and Au). According to the simulation results, we found that:the change of electron incident angle has a negligible impact on the yield of the noise X-ray photons;When the incident electron energy is less than 40 kV, the energy of the generated X-ray photons is concentrated in a range below 15 keV, the yield of noise X-ray photons is lower than the order of 10-6,which has little effect on the optical performance of the telescope.
Optical-Butterfly-Phenomena
Authors: Peng Hui
Published: February 2025

We show the Optical-Butterfly-Phenomena: the small differences in the structures of slits lead to profoundly different patterns.
A dual chaotic encryption scheme for index modulation orthogonal time frequency space PON system
Authors: Chen Qinghui , You Weihao , Wen Hong , Chen Ming , Ma Jie
Published: February 2025

In the paper, dual chaotic encryption is proposed and experimentally demonstrated to enhance the transmission performance and physical layer security for an index modulation orthogonal time frequency space (IM-OTFS). Besides, a peak-to-average power ratio optimized encryption scheme using random interleaved partitioning time segmentation (RIPTS) is also proposed to enhance the auto-correlation. To verify the PAPR and encryption performance of the proposed scheme, a back-to-back and 80 km standard single-mode fiber transmission passive optical network (PON) system is conducted. The experimental results show that compared to the IM-OTFS without PAPR optimization, the proposed RIPTS scheme can improve 4.3dB PAPR performance. Moreover, compared with PTS, IPTS and RPTS schemes, it can also improve 0.8dB, 0.6dB and 0.5dB PAPR performance. In addition, the key space size of index and subcarrier encryption was approximately 2⁶⁰⁰⁰ and 4⁴⁰ , respectively.
The Influence of Instagram and Brand Image on College Enrolling Interest at Universitas Muhammadiyah Jakarta
Authors: Fauzalia Dian , El Adawiyah Sa'diyah , Patrianti Tria , Swarnawati Aminah
Published: February 2025

The purpose of this study was to measure the influence of Instagram and brand image on interest in enrolling in college at Universitas Muhammadiyah Jakarta partially and simultaneously. This research approach uses quantitative research. This study used proportional stratified random sampling with 239 student respondents at SMAS Muhammadiyah 8 Ciputat and SMAN 8 South Tangerang City. The data collection technique was carried out using a questionnaire. The data analysis technique used multiple linear regression tests, namely the F and T-tests. This study found that Instagram and brand image positively and significantly affect interest in enrolling in college at the Universitas Muhammadiyah Jakarta, both partially and simultaneously. In conclusion, all hypotheses are accepted.

Kata Kunci: komunikasi bisnis, instagram, citra merek, minat, mendaftar kuliah
Geochemical Insights into the Paleodepositional Environment of the Garagu Formation, Gara Anticline, Kurdistan, Northern Iraq
Authors: Mirza Tola A. , Mohialdeen Ibrahim M.J. , Abdalla Shahra  O.
Published: February 2025

The Garagu Formation is mostly composed of carbonate layers with iron-rich horizons in the middle part. The geochemical evidence for the paleodepositional environment of the Garagu Formation in the Kurdistan Region of Iraq’s Gara anticline has been explored in this paper. A total of 9 samples from the Garagu Formation were analyzed by XRF for major elements and inductively coupled plasma–mass spectrometer for trace elements. From geochemical data of major and trace elements, including rare earth elements, a series of identification indexes, such as Sr/Ba, Rb/K2O, Th/U, U/Th, V/(V+Ni), δU, V/Sc, Sr/Cu, and C-Value ratios, are calculated, which can be used to indicate paleosalinity, ancient oxidizing environment, and paleoclimate conditions. As would be predicted in this limestone-dominated deposit, CaO has the greatest weight percentages of any sample. Several samples from the iron-rich mineralization in the middle part of the formation exhibit significant percentages of FeO. The elemental geochemical ratios indicate to saline shallow marine environment with lower salinity in the middle part of the formation. The paleoredox proxies revealed that the oxic to suboxic conditions prevailed during the deposition of the formation.
Pocketbook Voting in a Polarized Era: Economic Vulnerability and Anti-incumbent Voting in Presidential Elections
Authors: Schaffner Brian F. , Soler Caroline
Published: February 2025

Economic circumstances and vote choice have long been shown to be closely linked, but increasing partisan polarization may be weakening this traditional relationship. We examine whether pocketbook voting – the tendency to vote based on personal economic circumstances – still influences presidential vote choice in this polarized era. Using the Cooperative Election Study’s data from 2020 to 2024, we explore how different indicators of economic vulnerability affect support for incumbent presidential candidates. We find that while partisans remain largely loyal except when suffering the most difficult economic hardships, independent voters show strong anti-incumbent voting when they experience financial strains. Our findings suggest that personal economic circumstances remain influential in American elections, but primarily among voters without strong partisan attachments.
The Trump Effect: Nationalized Narratives and Congressional Outcomes in the 2024 Elections
Authors: Carson Jamie , Hitefield Aaron , Wall Megan
Published: February 2025

The 2024 elections resulted in a rightward shift, with Republicans taking back both the presidency and Senate while holding onto a very slim majority in the House of Representatives. Despite multiple felony convictions and near constant controversy, Donald Trump defeated Kamala Harris to win the presidency and all six of the swing states he had lost to Joe Biden in 2020. Down-ballot Republicans were also successful in their congressional races. Though Democrats had controlled the Senate since 2020, Republicans ultimately flipped four seats to take a 53–47 advantage in the chamber. Lastly, despite some concern among pundits that the dysfunctional Republican leadership in the House could negatively affect Republicans’ reelection chances across the board, Republicans were able to retain the House majority by a narrow margin of 220 to 215. This article highlights the political conditions and circumstances that defined the 2024 contest especially considering the increasingly nationalized nature of U.S. elections.
The Same F

1
but a Different F

2
– with Absolute Identity
Authors: Francescotti Robert
Published: February 2025

Here I present an analysis of what it is for an x and a y to be the same F. Unlike the Fregean Analysis (FRE), according to which ‘x is the same F as y’ is equivalent to ‘x is an F, y is an F, and x = y’, the analysis presented and defended here allows that there are possible cases in which x and y are the same F

1
but not the same F

2
even though x is an F

2
and y is an F

2
. The analysis offered here, FRE+, retains the conditions that FRE deems are necessary for being the same F while adding a further condition to allow that the same F

1
can be a different F

2
. Although FRE+ is compatible with there being such cases, FRE+ shares with FRE that the identity mentioned in the analysis is nothing other than absolute identity. Thus, FRE+ offers a way to allow that the same F

1
can be a different F

2
while avoiding conflict with the traditionally accepted logic of identity, and I argue without conflict with the Indiscernibility of Identicals in particular.