bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of novel inhibitors of P13K/AKT pathways: an integrated in-silico study towards the development of a new therapeutic agent against ovarian cancer
Authors: Adedotun Ibrahim Olaide , Abdul-Hammed Misbaudeen , Egunjobi Basirat Temidayo , Ismail Ubeydat Temitope , Yusuf Jemilat Yetunde , Afolabi Tolulope Irapada , Gbadebo Ibrahim Olajide
Published: May 2023

Ovarian cancer is a crucial gynaecological unmet medical disease with a high mortality rate. According to recent research, the phosphoinositol 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways are hyper-activated in the majority of ovarian cancer patients, necessitating the use of inhibitors. Over the years, phytochemicals have been used as alternative sources of therapeutic agents due to their reported biological activities and limited side effects. Curcuma longa (Tumeric), a reported ayurvedic medicine has also been noted for its anti-cancer properties. Thus, 155 phytochemicals from this plant and 2 reference drugs were evaluated for their inhibitory prowess against P13K/AKT receptor using a computer-aided drug design approach. The binding scores and inhibiting efficiencies were obtained via virtual screening. Molinspiration Chemoinformatics and SwissADME tools were used to investigate the drug-likeness properties and oral bioavailability of the compounds selected, while the ADMET SAR-2 website was used to conduct the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis. Other analyses performed on the selected compounds include bioactivity, activity spectra for substances (PASS) prediction, binding mode, and molecular interaction. The results revealed that Hopenone 1 (−8.8 kcal mol−1) and Epriprocurcumenol (−7.8 kcal mol−1) are potent inhibitors of the P13K receptor, while Epiprocurcumenol (−9.0 kcal mol−1), Procurcuminol (−8.6 kcal mol−1) and Curlone (−8.3 kcal mol−1) are potential inhibitors of AKT receptor. In comparison to Topotecan and Melphalan, they have better binding affinities, oral bioavailability, drug-likeness characteristics, ADMET properties, bioactivities, PASS properties, binding mechanism, and also interact well with the active site of the target receptor. As a result, this preliminary investigation suggests that these chemicals should be studied further for the design of novel ovarian cancer therapeutics.
Heart failure in patients with metabolic syndrome X
Authors:   University of Ilorin, College of Health Sciences, Ilorin, Nigeria, Olatunbosun Precious-Peculiar , El Hunjul Ghalib Nashaat ,   Department of Internal Medicine, Soba University Hopsital, Khartoum, Sudan, Patel Apurva ,   Medical College Baroda, Vadodara, India, Abbas Rabab Hunaid ,   Tbilisi State Medical University, Tbilisi, Georgia, Mody Shefali ,   Lokmanya Tilak Municipal Medical College, Mumbai, India, Masalha Ahmad ,   Ross University School of Medicine, Two Mile Hill, St. Michael, Barbados, Mehta Shivani ,   Xavier University School of Medicine, Aruba, Rizwan Shaista ,   Tbilisi State Medical University, Tbilisi, Georgia, Pareek Aayushi ,   University of Perpetual Help System, Dalta, Philippines, Jain Suhani ,   Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, India, Parambat Silmy Bakzer Cherat ,   Tbilisi State Medical University, Tbilisi, Georgia
Published: May 2023

Metabolic syndrome X has been known to be a risk factor for the development of cardiovascular dysfunction. Insulin resistance, diabetes mellitus and serum lipid abnormalities, which are all seen in metabolic syndrome X, have been found to negatively impact heart function, leading to heart failure in particular. Heart failure is a condition resulting when the heart is unable to perform its function of providing sufficient blood flow to meet the body’s requirements. The treatment of heart failure in metabolic syndrome X varies based on the various components of metabolic syndrome X, which include obesity, hyperglycemia, hypertension and dyslipidemia. Obesity is regarded as one of the derangements seen in patients with metabolic syndrome X. It is a significant risk factor in the development of cardiovascular disease, which may eventually lead to heart failure. However, the obesity paradox suggests that obesity provides a higher chance of survival in patients with metabolic syndrome and heart failure. This review article focuses on the pathophysiology of heart failure in patients who already have metabolic syndrome X, as well as the therapeutic management complexity of the two conditions taking into consideration the protective role provided by obesity.
Estágio Curricular Supervisionado e Trabalho de Conclusão de Curso em Enfermagem: bacharelado e licenciatura
Authors: Rodrigues Rosa Maria , Reis Alessandra Crystian Engles dos , Machineski Gicelle Galvan , Barhart Jéssica Borges Lúcio , Tonini Nelsi Salete , Conterno Solange de Fátima Reis
Published: May 2023

Objetivo: avaliar a formação recebida nas atividades de Estágio Curricular Supervisionado e Trabalho de Conclusão de Curso de graduação em enfermagem. Método: pesquisa quanti-qualitativa, com dados coletados nos anos de 2018 e 2019, com alunos da Enfermagem que responderam a um questionário on-line assíncrono, pela ferramenta Limesurvey. Os dados quantitativos foram submetidos à análise descritiva e os qualitativos à análise de conteúdo. Resultados: 11 eram concluintes em 2018 e 25, em 2019 e responderam ao questionário 7 e 10, respectivamente. Avaliaram positivamente o ensino-aprendizagem vivenciado, elencaram desafios, mas visualizaram o desenvolvimento de autonomia, autoconfiança, crescimento profissional e pessoal; superação de inseguranças e empenho do serviço em acolhê-los. Na monografia, exercício das normas e definição de critérios de avaliação seriam positivos e papel dos professores. Conclusões: a conclusão da graduação pelo estágio e monografia é momento insubstituível, viabilizando o exercício da autonomia e apoiados pelo enfermeiro do serviço e professor supervisor.
Cuidado de enfermagem no ambiente hospitalar aos pacientes com lesões crônicas
Authors: Busanello Josefine , Viana Diogo da Rosa , Garcia Raquel Potter , Simon Bruna Sodré , Alves Camila Bueno
Published: May 2023

Objetivos: conhecer a percepção dos enfermeiros acerca do cuidado de enfermagem no ambiente hospitalar aos pacientes com lesões crônicas. Método: pesquisa descritiva, com 20 enfermeiros que atuam no cuidado direto ao paciente, de um hospital da fronteira oeste do Rio Grande do Sul. A coleta de dados ocorreu em abril de 2017, por meio de entrevista semiestruturada. Resultados: predomina, no ambiente hospitalar investigado, a lesão por pressão. Os cuidados de enfermagem estão direcionados à avaliação da lesão e técnica de curativo. A falta de materiais foi referenciada como a principal dificuldade para organizar o cuidado. Conclusões: a percepção dos enfermeiros sobre os cuidados de enfermagem aos pacientes com lesões crônicas está restrita à lesão. Não há uma perspectiva que contemple as demais necessidades de cuidados que também interferem na recuperação e na cicatrização da lesão, como as questões associadas às doenças de base, e os problemas socioculturais.
Carnet Japon avril 2015
Authors: Sauvagnargues Anne
Published: May 2023

O ensaio visual do Dossiê Deleuze: Modos de Usar apresenta pinturas da artista e filósofa francês Anne Sauvagnargues que compõem seu Carnet Japon avril 2015, uma coleção de imagens capturadas em seu cotidiano de deslocamentos no transporte público. O ensaio inicia com uma apresentação de Lilian Hack. Japan  April 2015 notebookAbstract: The visual essay which is part of the Dossiê Deleuze: Modes of Use features paintings by the French artist and philosopher Anne Sauvagnargues who composed  her Carnet Japon avril 2015 (Japan April 2015 notebook) from a collection of images captured in her daily commute using public transport. The essay begins with a presentation by Lilian Hack.
Comparison of Effects of Computer-Based Instructional Support on Academic Achievement of University Students Regarding Meiosis
Authors: Doğru M. Said , Özsevgeç Lale Cerrah
Published: May 2023

This study aimed to compare the effects of computer-based lessons versus traditional lessons on achievement of university students regarding meiotic cell division. A pretest-intervention-posttest design was used. To determine the effect of our computer-based intervention, we established a control group. In total, 100 second-year university students from a science education department (50 in the experimental group, 50 in the control group) participated in the study. Data were derived from a meiosis content test and interviews. The results showed the computer-based lesson had significant positive effects on student learning.
Evaluations of Action and Inaction Decision-makers in Risky Decisions Resulting in Negative Outcomes: Inaction Agents Are Preferred to and Perceived as More Competent and Normative Than Action Agents
Authors: Fillon Adrien A. , Strauch Luna , Feldman Gilad
Published: May 2023

Research on action and inaction in judgement and decision making has shown that for choices in risky situations resulting in negative outcomes, people tend to prefer inaction over action and regret actions more than inactions. We built on this idea to test whether the established norm preference for inaction over action affects evaluations of decision-makers, and results in stronger preference for an agent who favors inaction over action in risky decisions resulting in negative outcomes. We conducted three pre-registered experiments via the Prolific platform, replicating and further extending the classic action-effect paradigm (overall N = 1138, 355 male, 746 female, 37 others, Mage= 36.98, SDage= 12.34) to examine perceptions of competence and trustworthiness of action versus inaction agents. First, we successfully replicated action-effect (d = 0.58 to 0.96). We then found that participants indeed tended to evaluate an inaction protagonist as more competent, trustworthy, and inline with social norms than an action protagonist (d = 0.05 to d = 0.61). Results concerning our extensions examining perceived social norms and joy attributions over positive outcomes were less clear. Finally, we found that normality moderated the preference-inaction effect into a preference-action effect: Negative prior outcomes led participants to prefer action actors to inaction actors and to find those to be more competent and normative. Overall, we found that, in the context of negative outcomes, inaction is perceived as more trustworthy than action. We concluded that action and inaction seem to extend to social evaluations of agents and that trustworthiness can be affected by action and inaction, context, and norms. All materials, data, and code are available on: https://osf.io/a8e4d/
A Federal Nightmare: The People’s Republic of China and the Breakup of Yugoslavia
Authors: Brusadelli Federico
Published: May 2023

This paper explores how the breakup of Yugoslavia was interpreted, commented on, and used for internal and international political purposes in China, with a focus on the role played by key concepts such as “federalism” and “sovereignty” in consolidating the Chinese interpretation of those dramatic events, and ultimately in shaping the CCP’s pro-Milošević stance in the dramatic unfolding of the conflict in Kosovo. In particular, the preoccupation with separatism and international humanitarian intervention, and the interpretation of the Yugoslav dissolution as a federal failure by the Chinese elite, help link the global event (the collapse of the Balkan political order) to the local Chinese debate on centralization and decentralization, an issue that had been polarizing the CCP since the launch of the “reform and opening” agenda by Deng Xiaoping at the end of the 1970s.
Crankshaft Hardness Quality Evaluation of Passenger Car
Authors: R. Firdaus  , P. Paryanto  , S. Sulardjaka
Published: May 2023

A crankshaft is a part of the main engine components and plays a critical role in car performance. The crankshaft component consists of journals, pins, and flange that experience induction hardening treatment to increase their hardness. Hardness case depth represents important hardness criteria achieved by the depth of induction hardening process. This paper aims to evaluate crankshaft hardness quality by analyzing hardness case depth measurement. The control chart shows the results, which presents process stability to indicate abnormal processes. The capability process is also performed to process consideration. Evaluation results show hardness case depth is not at its best performance even though process capability meets product requirements. Affected factors to process stability are manpower, method, material, measurement, machine and environment. Implemented improvements based on the problem root cause to eliminate influenced factors and achieve stable process are delivered.
The relationship between mental fatigue, depression, and cognition in Graves’ disease
Authors: Johansson Birgitta , Holmberg Mats , Skau Simon , Malmgren Helge , Filipsson Nyström Helena
Published: May 2023

Objective

Mental fatigue, depression, anxiety, and cognitive complaints are common in Graves’ disease (GD). Our aims were to assess the relationship between these variables in patients with GD during both hyperthyroidism and a long stable euthyroidism.

Methods

A prospective longitudinal case-control study where 65 premenopausal women diagnosed with GD and 65 matched controls were assessed twice with 15 months in between. The first visit for patients was in overt hyperthyroidism and the second after treatment.

Results

During the hyperthyroid phase, mental fatigue, depression, and anxiety were significantly increased for GD patients compared to controls (all P < 0.001). Among GD patients, 89% reported mental fatigue and among controls 14%. No difference in cognitive tests was found. After 15 months, significant improvements for GD patients after treatment were found for the items of mental fatigue, depression, and anxiety (all P < 0.001), but these were unchanged in controls. GD patients reported residual mental fatigue (38%), 23% without depression, and 15% mental fatigue combined with depression. Self-reported cognitive complaints were pronounced while cognitive tests did not reveal any deficiencies.

Conclusion

Mental fatigue and emotional distress are common in the hyperthyroid phase. These improve with treatment but are still more common in GD patients after 15 months of therapy than in controls. The residual mental fatigue is shown to be a phenomenon distinct from depression in this study. This indicates the importance of assessing mental fatigue in GD patients and underlines the need for rehabilitation and healthcare support as fatigue will have consequences for work ability.
The influence of rainfall and temperature on radial growth of urban trees under the impact of steel industry pollution
Authors: Neto Thayanne Caroline Castor , Lousada José Luis Penetra Cerveira , Fontana Cláudia , Moreira Carolina Gomes , Latorraca João Vicente de Figueiredo
Published: May 2023

The aim of this study was to analyze the growth rings and evaluate the effect of the urban environment on the growth of Terminalia catappa L. under intense industrial activity. At least two wood samples were obtained from each tree with an increment borer. The regions of Volta Redonda (Northwest and Southeast regions) and Resende (used as control) were established for the collection. The dendrochronological potential of T. catappa indicated sensitivity to precipitation and temperature in a more exposed urban and industrial steel pollution area because there were differences in growth when compared to an area less exposed to the same pollution. Thus, it was possible to conclude that this species has the potential to be used as a bioindicator of anthropogenic activities. In addition, the delimitation of the growth rings of the studied species contributes to the realization of future dendrochronological studies, expanding the understanding of the behavior of this species present in urban environments at different regional scales. This study reinforces the importance of rainfall and temperature in regulating radial growth in tropical forests.
Teaching Computing to Middle and High School Students from a Low Socio-Economic Status Background: A Systematic Literature Review
Authors: Martins Ramon Mayor , Gresse von Wangenheim Christiane
Published: May 2023

Information technology (IT) is transforming the world. Therefore, exposing students to computing at an early age is important. And, although computing is being introduced into schools, students from a low socio-economic status background still do not have such an opportunity. Furthermore, existing computing programs may need to be adjusted in accordance to the specific characteristics of these students in order to help them to achieve the learning goals. Aiming at bringing computing education to all middle and high-school students, we performed a systematic literature review, in order to analyze the content, pedagogy, technology, as well as the main findings of instructional units that teach computing in this context. First results show that these students are able to learn computing, including concepts ranging from algorithms and programming languages to artificial intelligence. Difficulties are mainly linked to the lack of infrastructure and the lack of pre-existing knowledge in using IT as well as creating computing artifacts. Solutions include centralized teaching in assistive centers as well as a stronger emphasis on unplugged strategies. However, there seems to be a lack of more research on teaching computing to students from a low socio-economic status background, unlocking their potential as well to foster their participation in an increasing IT market.
Experimental method for determining the supply current of a PMOS power transistor for use as a RADFET dosimeter
Authors: Mendonça Eduardo Gomes , Cavalcante Tassio Cortês , Vaz Rafael Galhardo , Pereira Junior Evaldo Carlos Fonseca , Gonçalez Odair Lelis
Published: May 2023

Radiation Sensitive MOSFETs (RADFETs) have been commonly used as ionizing radiation dosimeters. The threshold voltage variation is the main transistor parameter used for radiation dosimetry, as this voltage variation is directly related to total dose and it can be easily determined by using simple measurement and biasing circuits. In this work it is presented a novel experimental method to determine the optimal drain-source current value to be supplied to a p-type MOSFET used in a traditional RADFET configuration (diode connected transistor) for monitoring of the accumulated X- and gamma-radiation dose. Experimental results from irradiations with 60Co gamma-rays and comparison measurements with semiconductor analyzer indicate that lower supply current values result in more precise dose measurement results.
Un aspetto dell'intelligence nel mondo greco: la parola d'ordine
Authors: Santagati Elena
Published: May 2023

In the ancient world, visual and verbal σύνθημα appears to be of enormous importance during conflicts. It is one of the elements pertaining to the management and organization of political intelligence. In particular, the signal, declined in the verbal form, for its fundamental function of ‘recognition’ to validate the belonging of a soldier to a particular side, had to be chosen with great care. Its use appears to have intensified and, at the same time, perfected, according to what can be gathered from historiographical evidence and from military treatises, at the time of the transition between the Classical and Hellenistic eras, when the way of waging war also underwent an important transformation.
Longitudinal modifiable risk and protective factors of internet gaming disorder: A systematic review and meta-analysis
Authors: Zhuang Xiaoyu , Zhang Youmin , Tang Xinfeng , Ng Ting Kin , Lin Jiaxi , Yang Xue
Published: May 2023

Background and aims

The study aims to thoroughly understand the causal and precedent modifiable risk or protective factors for Internet Gaming Disorder (IGD), a newly defined and prevalent mental disorder.

Methods

We performed a systematic review on quality-designed longitudinal studies based on five online databases: MEDLINE, PsycINFO, Embase, PubMed, and Web of Science. Studies were included in the meta-analysis if they addressed IGD, adopted longitudinal, prospective, or cohort study designs, presented modifiable factors of IGD, and reported the effect sizes for correlations. Pooled Pearson's correlations were calculated using the random effects model.

Results

Thirty-nine studies with 37,042 subjects were included. We identified 34 modifiable factors, including 23 intrapersonal factors (e.g., gaming time, loneliness, etc.), 10 interpersonal factors (e.g., peer relationship, social support, etc.), and 1 environmental factor (i.e., school engagement). Age, the male ratio, study region, and study years were significant moderators.

Discussion and conclusions

Intrapersonal factors were stronger predictors than interpersonal and environmental factors. It may imply that individual-based theories are more powerful to explain the development of IGD. Longitudinal research on the environmental factors of IGD was lacking; more studies are warranted. The identified modifiable factors would help to guide effective interventions for IGD reduction and prevention.
Synthesis of magnetite (Fe3O4) coated pinecone crosslinked to cyclodextrin and its adsorption behaviour for 4-Nitrophenol: Response surface methodology
Authors: Pholosi Agnes , Sanni Saheed O.
Published: May 2023

This study reports the systematic development of cyclodextrin magnetic biocomposite for the remediation of 4-nitrophenol from wastewater. Magnetic biocomposite was synthesized by co-precipitation of Fe2+ and Fe3+ in the presence of NaOH treated pine-cone followed by cross-linking with cyclodextrin using epichlorohydrin, and achieved by an optimization tool. The experiments were designed and the interaction between the working condition variables (CM-CD mass, MNP mass, time and temperature) on the % iron content and 4-NP adsorption capacity were optimized by response surface methodology approach. The temperature and MNP mass both have positive influences on the % iron content and 4-NP adsorption capacity. Crosslinking of cyclodextrin onto magnetite surface was confirmed by transmission electron microscopy, x-ray diffraction, vibrating scanning magnetometer, Fourier transform infrared spectroscopy and thermal gravimetric analysis). Optimum conditions of MNP-EPI-CD were 2.0 g of CM-β-CD, 0.83 g of MNP at 30 °C for 7.40 h which can remove 15.32 mg/g of 4-nitrophenol.

Graphical abstract
TEKNIK PEMELIHARAAN LARVA IKAN KAKAP PUTIH (Lates calcarifer) DI CV. BALI AKKUA MARINE DESA MUSI KECAMATAN GEROGAK KABUPATEN BULELENG PROVINSI BALI
Authors: Halim Atika Marisa , Widodo Agus , Arifin M. Zainal , Akbar M. Baihaqi
Published: May 2023

Lates calcarifer is one type of Indonesian marine fish that has high economic value. Demand also continues to increase both domestically and abroad such as countries in Europe (Italy, Spain, and France). However, if it is not supported by the availability of sufficient larvae, the market demand will also not be fulfilled. The purpose of this study was to determine the technique of rearing L.calcarifer larvae and to find out the production results in CV. Bali Akkua Marine. 100.000 eggs selected from Balai Besar Riset Budidaya Laut dan Penyuluhan Perikanan, Gondol, Bali, Indonesia.The stages of egg rearing include Egg Observation (whole round eggs and floating and white in color),  acclimatization for ± 30 minutes. Eggs that have been stocked will hatch after 14-17 hours after fertilization. The optimal temperature for hatching eggs is between 27°C - 29°C. The calculation of the hatching rate (HR) obtained in the field from 100,000 eggs is 84.5%. Larvae of L. calcarifer reared reach 7-9 cm and require 63-80 days from hatching eggs. After hatching, the larvae eggs will be harvested if they reach a size of 0,6-1 cm and  SR of 75.1% . During the seed maintenance activities, the survival rate (SR) of L. calcarifer was 48.4% of the 63.500 larvae harvested.
Association of Calcium Index and Myocardial Blood Flow in Non-Obstructive Atherosclerotic Lesion of the Coronary Arteries
Authors: Maltseva Alina N. , Kopeva Kristina V. , Mochula Andrew V. , Grakova Elena V. , Zavadovsky Konstantin V. , Popov Sergey V.
Published: May 2023

Background. Over the past few years, scientific data have demonstrated that patients with non-obstructive coronary artery disease can have high risk for adverse cardiovascular events (ACE) despite the absence of severe coronary obstruction. From this point of view, some patients require special monitoring and treatment; we have to find new methods for stratification of the risk of ACE. Aims to study the association of coronary artery calcification (CCA) with indicators of myocardial blood flow (MBF) and myocardial flow reserve (MFR) in patients with non-obstructive coronary artery disease (CAD). Methods. The study included patients (n = 52) with non-obstructive CAD ( 50%), identified by CCTA. All patients received dynamic myocardial SPECT according to the two-day rest-stress protocol with the radiopharmaceutical agent 99mTc-methoxy-isobutyl-isotnitrile and the pharmacological stress-test (adenosine triphosphate 160 mcg/kg/min) to determine quantitative indicators of MBF and MFR. Depending on the calcium index (CI), three groups of patients were formed: 1 without CCA (CI = 0 Agatston units), 19 patients; 2 Mild CCA (CI = 1100 Agatston units), 21 patients; 3 Moderate CCA (CI = 101400 Agatston units), 12 patients. Results. The study included 52 patients (age 55.0 9.8 years, 36 men). The groups differed statistically significantly (p 0.05) in terms of quantitative scintigraphic parameters: stress-MBF, MFR and MBF. When analyzing the groups in pairs, it was found that stress-MBF and MBF were significantly lower in the group with moderate CCA compared to the group without CCA, and MFR was lower in the group with moderate CCA compared to the groups without CCA and with mild CCA. Correlation analysis revealed significant relationships between CI and scintigraphic parameters: stress-MBF ( = 0.46; p = 0.003), MFR ( = 0.48; p = 0.001), MBF ( = 0.48; p = 0.0008), SSS ( = 0.34; p = 0.02) and SDS ( = 0.28; p = 0.046). Conclusions. Even with non-obstructive CAD, identified by CCTA, there is a decrease in MBF and MFR inversely proportional to the level of CI, which can be considered as an early marker of impaired vasodilation reserve of the vascular wall, which develops in atherosclerosis of the coronary artery.
Tissue-Engineered Constructions for the Needs of Cardiovascular Surgery: Possibilities of Personalization and Prospects for Use (Problem Article)
Authors: Antonova Larisa V. , Barbarash Olga L. , Barbarash Leonid S.
Published: May 2023

In the market for products for the needs of cardiovascular surgery, there is still no effective vascular prosthesis with a diameter of less than 4 mm, despite the continuous increase in the incidence of atherosclerosis and the increase in the number of surgical operations to restore blood flow in the affected arteries. At the same time, vascular tissue engineering has diverse methodological approaches for the development of effective functionally active small-diameter vascular prostheses suitable for adaptive growth and regeneration in situ. An important aspect is the possibility of personalizing the created prostheses not only by taking into account the individual anatomy of the patients vascular bed, but also by using autologous components to create such a prosthesis, which can be obtained directly from the recipient. The presented problematic article reflects the main results on the creation of biodegradable vascular prostheses of small diameter, obtained at the Research Institute of the Research institute for complex issues of cardiovascular diseases (Kemerovo). The functionality of the prostheses was provided both through the incorporation of biologically active components with proangiogenic potential for the purpose of complete remodeling in situ, and the formation of cell-populated vascular prostheses using autologous cells and proteins from patients with coronary heart disease. In the future, these vascular prostheses can cover the clinical need for elective and emergency cardiovascular surgery, neuro- and microsurgery, and military field vascular surgery.
Minimally Invasive Surgery for Septal Defects Inchild: Literature Review
Authors: Shatalov Konstantin V. , Arnautova Irina V. , Abdurazakov Magomed A.
Published: May 2023

Nowadays a minimally invasive approach is a rapidly evolving strategy in particular in the field of congenital heart surgery. The main advantage of minimally invasive approaches is less trauma to a patient which positively effects early postoperative period and recovery after surgery. Own to continuous technological progress and growing experience minimally invasive approaches become widely used in cardiac surgery as well as in treatments of congenital heart defects. This review highlights the main problems and their potential solutions in using minimally invasive approaches in surgical treatment of atrial septal defect, ventricular septal defect, partial atrioventricular canal, partial anomalous pulmonary venous drainage. We describe specific considerations of cardiopulmonary bypass, operative techniques and results of minimally invasive approanes.
The Recent Advances to Increase Nutrient Utilization of Dietary Plant Proteins by Enzyme Supplementation and Fermentation in Rainbow Trout (Oncorhynchus mykiss): A Review
Authors: ENGİN Kenan , KOYUNCU Cafer
Published: May 2023

Aquaculture is the fastest growing animal production sector globally. However, its sustainability heavily relies on the development of nutritionally balanced cost-effective and environmentally friendly aqua feeds for fish and crustacean species that are already being farmed or the candidate species for intensive farming in the future around the world. Therefore, feeds produced for farmed aquatic species should be highly digestible in terms of nitrogen and phosphorous contents in order to avoid excessive release of these nutrients into the water column through solid and soluble discharge. Excessive nitrogen and phosphorous in the water are the main reason of eutrophication occurring causing severe depletion of oxygen and creating hypoxia for many aquatic organisms living inside water column. Strategies like formulating aqua feeds on required DP/DE (Digestible Protein/Digestible non-protein Energy) basis for farmed species and using synthetic enzymes as feed additives in order to make plant phosphorous bioavailable for fish are being utilized by the commercial aqua feed producers around the world. Fermenting plant protein ingredients with microorganisms and using prebiotics and probiotics as feed additives are also considered a viable option to reduce the nutrient load of aquafarms since these have been shown to increase the digestibility of feed ingredients via increased gut health maintaining the optimal composition and environmental conditions for gut microbiome. In this regard, this review is intended to emphasize the importance of the sustainability efforts of aquaculture production from the perspectives of environmentally friendly aqua feed formulations and improvements based on the recent knowledge gathered for the effects of dietary external enzyme supplementation and fermentation of plant ingredients on growth and wellbeing of rainbow trout (Oncorhynchus mykiss) throughout the world.
Benchmarking Stability of Iridium Oxide in Acidic Media under Oxygen Evolution Conditions: A Review: Part I
Authors: Murawski James , Scott Soren B. , Rao Reshma , Rigg Katie , Zalitis Chris , Stevens James , Sharman Jonathan , Hinds Gareth , Stephens Ifan E. L.
Published: May 2023

State-of-the-art proton exchange membrane (PEM) electrolysers employ iridium-based catalysts to facilitate oxygen evolution at the anode. To enable scale-up of the technology to the terawatt level, further improvements in the iridium utilisation are needed, without incurring additional overpotential losses or reducing the device lifetime. The research community has only recently started to attempt systematic benchmarking of catalyst stability. Short term electrochemical methods alone are insufficient to predict catalyst degradation; they can both underestimate and overestimate catalyst durability. Complementary techniques, such as inductively coupled plasma-mass spectrometry (ICP-MS), are required to provide more reliable assessment of the amount of catalyst lost through dissolution. In Part I, we critically review the state of the art in probing degradation of iridium-based oxide catalysts.
Effects of organic content on sewage sludge compression behaviour
Authors: Yang Rui-min , Wei Ren-wei , Zhang Zhen-ning , Zheng Teng-long
Published: May 2023

Five sewage sludge specimens with different organic contents were prepared by mixing mass ratios of 0, 5, 10, 20 and 40% dry soil powder into raw sewage sludge. The addition of dry soil powder can reduce the organic content of sewage sludge without significantly changing its particle composition. Oedometer tests were conducted, starting from a small effective vertical stress [Formula: see text]. It is observed that the [Formula: see text] compression curves show an inverse ‘S’ shape due to suction pressure resisting deformation. The suction pressure decreases exponentially with the organic content, a regression equation for which is provided. Burland’s concept of the intrinsic compression line (ICL) is adopted for correlating the compression curves of sludge with various organic contents. It is found that the ICL with a high organic content lies above the low one – that is, the higher the organic content, the greater the void index. In addition, the shape of the ICL for organic sludges is an inverse S rather than slightly concave upwards for inorganic reconstituted clays. An average ICL is provided to normalise the compression curves of sludges with different organic contents. The intrinsic compression parameters [Formula: see text] and [Formula: see text] can be correlated with the organic content, which increase linearly with the organic content, and the regression equations for them are provided.
Thermal expansion and corrosion resistance of cobalt-chromium alloys fabricated by contemporary manufacturing processes. An in vitro study
Authors:   Department of Prosthodontics, Narayana Dental College and Hospital, Nellore, Balaji Bonothu ,   Andhra Pradesh, India, Vinnakota Dileep Nag ,   Department of Prosthodontics, Narayana Dental College and Hospital, Nellore; Andhra Pradesh, India, Sankar V Vijaya ,   Department of Prosthodontics, Narayana Dental College and Hospital, Nellore; Andhra Pradesh, India, Pottem Srinivas Rao ,   Department of Prosthodontics, Narayana Dental College and Hospital, Nellore; Andhra Pradesh, India
Published: May 2023

In Purpose: The fabrication technique can influence the mechanical properties of Cobalt-Chromium (Co-Cr) dental alloys. Hence, the present study aims to determine the corrosion resistance and thermal expansion of alloys manufactured using three contemporary techniques. Material and Methods: A total of nine specimens of Co-Cr alloy were prepared according to ISO 22674 by each one of the three manufacturing processes (three in each process); conventional casting, direct metal laser sintering (DMLS) and milling (MIL). All these specimens were tested for coefficient of thermal expansion and corrosion resistance. The data was tabulated and analyzed statistically. Results: The difference in the thermal expansion of alloys fabricated using three techniques was non-significant at almost all the temperatures from 50 ºC to 950 ºC (p>0.05), except 450 ºC and 600 °C. The polarization resistance of specimens manufactured using the conventional method was more compared to DMLS and MIL at pH 5 (Conventional>MIL>DMLS) (p<0.001). Conclusion: The thermal expansion behavior of alloys manufactured using the three selected techniques were similar, whereas, at acidic pH, the corrosion resistance of conventional and MIL were better than the DMLS.
Mortarboard Review
Authors: Moss Jennifer D. , Parham Joel
Published: May 2023

This article is the first in a series of planned reviews to be published annually that highlight a selection of dissertations. Some aspects of the selection and review methodology may be adjusted in coming issues as the process is refined to maximize the value to the field. Twenty-three Montessori-related dissertations completed during 2021 and 2022 were identified that represented five broad categories based on topic or subject matter. Two dissertations were selected for inclusion in this review because they represent high-quality research in areas that are of particular relevance and value to the field at this time: (a) public Montessori education and issues of equity and intercultural competence and (b) teacher perspectives and technology.
Application of machine learning algorithm for career guidance of university applicants
Authors:   Ural Federal University, Zabokritskaya Lyubov D. , Oreshkina Tatyana A. ,   Ural Federal University, Obabkov Ilya N. ,   Ural Federal University, Chepurov Evgeny G. ,   Ural Federal University
Published: May 2023

The aim of the article is to describe the experience of implementing our own software product (Wizard UrFU) for career guidance and navigation of university entrants. The importance of introducing digital technologies for career guidance and navigation of university entrants is substantiated. The article addresses both sociological and IT tasks. On the part of information technology, a description is given of the main methods on which the work of a software product for vocational guidance and navigation of applicants can be built. In particular, we have proved that the most promising is the complex method, which is based on a combination of several methods and algorithms for the operation of neural networks for vocational guidance and navigation of applicants. The article describes the algorithm of the software product developed by our team. We show that this algorithm is based on the analysis of digital traces of applicants in the social network VKontakte. The algorithm uses the machine learning method. We also show that the career guidance system in the Wizard web application is based on a comparison of profile data in the VKontakte social network and generalized data of university students successfully enrolled in one of the educational programs. We analyzed the statistics of recommendations of educational programs to UrFU applicants using the UrFU Wizard web application using the Yandex. Metrics. The socio-demographic portrait of the UrFU Wizard software product user is a young man (or woman) aged 18 to 24 from Yekaterinburg or Sverdlovsk Oblast. This description fully coincides with the main target audience of the Ural Federal University. As a result, 12,780 potential applicants of Ural Federal University started submitting documents through the web application. In addition, 32% or 15,293 applicants made a transition to the institutions’ social networks and educational programs for a more detailed acquaintance. The analysis of the admission campaign results showed that all educational programs that were in the TOP of recommended areas had a significant increase in applicants compared to previous years. In general, Ural Federal University in 2021 held the most massive admission campaign among higher educational institutions in the Russian Federation. In our opinion, the use of services based on the work of artificial intelligence for career guidance and navigation of applicants of a higher educational institution allows a successful solution of the following tasks: to expand the geography of admission without holding face-to-face meetings with applicants; to increase the reach of the advertising campaign and personalize advertising offers; to attract creative and motivated youth; to help the applicant to make the right choice of the direction of training and thereby increase the motivation to study.
Functions of dialect vocabulary in internet communication
Authors:   Tomsk State University, Zyuzkova Natalya A.
Published: May 2023

The article analyzes the functioning of the Russian dialect vocabulary in modern discursive practices. The aim of the article is to determine the functions of dialect vocabulary in Internet communication. The relevance of the article lies in the need to study modern processes in Internet communication, the definition of trends in the development of language and speech, as well as the role of dialect vocabulary in the formation of the Russian-language communicative sphere. The novelty of the research lies in addressing the problem of discursive and functional heterogeneity of the language of the Internet, identifying zones and factors of such heterogeneity, systematizing functions of dialect words determined by the specifics of internet communication. The materials of the research include 80 text comments selected from the social network VKontakte and containing dialect lexemes belonging to the lexicalthematic group “Person”. Lexical elements were selected from the Vershinino Dictionary and include lexemes characterizing a person by social status, character, naming the features of human behavior and actions performed by a person. The research employed the descriptive method implemented by the methods of contextual analysis, systematization and classification of material. The method of partial sampling was used to collect the material. The first stage of the research described the functions of dialect vocabulary in different types of texts and discourses. At the second stage the features of the Internet as a source of material for linguistic analysis were characterized, including: accessibility, anonymity, democracy and equal positions of communicants. The third stage involved the selection of dialect material from the dictionary and the collection of comments from the social network VKontakte. The fourth stage identified the functions of the dialect word in internet communication: emotional-expressive, nominative, stylistic, voluntative, characterizing, invective, identifying functions, the function of addressing. It was determined that the allocation of the functions of dialect vocabulary varies depending on the criteria underlying classifications authors propose, depends on the subject and sphere of functioning of the text materials, their goals. The article proves that social networks make it possible to determine the functions of dialect elements, their lexical semantics, local connotations and areas.
Protocols for processing of fresh murine tissues for flow cytometry v1
Authors: Rose E Ranoa Diana
Published: May 2023

To assess the immune cell composition immediately after 237 CAR treatment, we performed immunophenotyping by flow cytometry on samples from blood, spleen, pancreas, and ascites fluid recovered from ID8Cosmc-KO-bearing mice
SRB assay for measuring target cell killing v1
Authors: Rose E Ranoa Diana
Published: May 2023

The Sulforhodamine B colorimetric assay was used to measure effector CAR T cell killing of their target tumor cells.
pool-seq pipeline - Stanford et al. v1
Authors: not provided brenna.cm.stanford
Published: May 2023

Determining cryptic species and diversity in at-risk species is necessary for the understanding and conservation of biodiversity. The endangered Banff Springs Snail, Physella johnsoni, inhabits seven highly specialized thermal springs in Banff National Park, Alberta, Canada. However, it has been difficult to reconcile its species status to the much more common Physella gyrina using ecology, morphology and genetics. Here we used pooled whole-genome sequencing to characterize genomic variation and structure among five populations of P. johnsoni and three geographical proximate P. gyrina populations. By comparing over two million single nucleotide polymorphisms, we detected substantial genetic distance (pairwise FST of 0.27 to 0.44) between P. johnsoni and P. gyrina, indicative of unique gene pools. Genetic clusters among populations were found for both species, with up to 10% for P. johnsoniand 30% for P. gyrina of genetic variation being explained by population structure. P. johnsoni was found to have lower genetic diversity compared to P. gyrina, however, no patterns of were observed between genetic diversity and population minimums. Our results confirm that designation of P. johnsoni as an endangered species is warranted and that both P. johnsoniand P. gyrina exhibit microgeographic population genomic structure suggestive of rapid local adaptation and/or genetic drift within environments. This study showcases the utility of genomics to resolve patterns of cryptic species and diversity for effective conservation management. Future studies on the functional genomic diversity of P. johnsoni populations are needed to test for the possible role of selection within this thermal spring environment.
RECC Corpus Stimulus set and protocol v1
Authors: Cavicchio Federica
Published: May 2023

The Rovereto Emotion and Cooperation Corpus (RECC) is a new resource collected to investigate the relationship between cooperation and emotions in an interactive setting. Previous attempts at collecting corpora to study emotions have shown that this data are often quite difficult to classify and analyse, and coding schemes to explore emotions are usually found not to be reliable. We collected a corpus of task-oriented (MapTask-style) dialogues in Italian, in which the segments of emotional interest are identified using psycho-physiological indexes (Heart Rate and Galvanic Skin Conductance), which are highly reliable. We then annotated these segments with novel multimodal annotation schemes for cooperation (in terms of effort) and facial expressions (an indicator of emotional state). High agreement was obtained among coders on all the features. The RECC corpus is, to our knowledge, the first resource with psycho-physiological data aligned with verbal and nonverbal behaviour data. Attached are the giver and follower maps.
Immunohistochemistry of tissue sections from formalin-fixed paraffin embedded (FFPE) samples v1
Authors: Li Terri
Published: May 2023

H&E staining and immunohistochemistry of tissue sections from formalin-fixed paraffin embedded (FFPE) murine tissue samples were performed by the University of Chicago Human Tissue Resource Center core facility.
Voter Disenchantment in the Aftermath of the 2005 EU Constitutional Referendum in France
Authors: Ruiz Stefan Sliwa , Linsi Lukas , Jaupart Pascal
Published: May 2023

In a popular referendum in 2005, French voters rejected their country’s adoption of a proposed EU Constitution. Yet, in seeming defiance of the popular vote, the government subsequently proceeded to implement the core of the legislation without consulting the public again. This article empirically examines the electoral impacts of these events. We build a comprehensive fine-grained dataset of nationwide election results for more than 36,000 metropolitan French municipalities. Employing cross-sectional analysis for all national elections held in the decade after the referendum vote, we find that the strength of a municipality’s rejection of the EU Constitution in 2005 is associated with a lower voter turnout, higher shares of blank votes, and larger gains for anti-system parties in subsequent elections. The findings are robust to various modelling choices and the inclusion of a large array of controls. The results indicate that bypassing a popular vote could entail protracted adverse effects on the quality of democratic participation and deliberation.