bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship Between Systemic Immune Inflammation Index and Prognosis in Patients with COVID-19
Authors: NERGİZ Sebnem , OZTURK Onder
Published: December 2022

Objectives: Inflammation and coagulation perform a substantial act in the pathophysiology of COVID-19 cases. The systemic immune-inflammation index (SII) is a novel prognosis and inflamation index. In this study, we aimed to research the relation between SII and prognosis in COVID-19 patients.

Methods: 315 cases (males, 136 ; females, 179 ; 63.2 ± 11.4 years) with positive PCR and lung tomography evidences compatible with COVID-19 pneumonia were recorded in the research. Patients were separated into 2 groups according to the mortality (Group 1; Surviving patients, Group 2; Ex patients). Clinical, demographic, and laboratory datas for whole patients were registered Laboratory datas were measured from blood parameters taken during hospitalization. The SII was calculated as “ SII = neutrophil count × platelet count / lymphocyte count ”.

Results: The mean hospital stay of the patients is 12 (5-26) days. When the patients were assessment of according to clinical features, an important distinction was found between the two groups according to age, gender, cardiovascular disease, chronic renal failure, neurolvascular disease, and diabetes mellitus. When the patients were evaluated according to laboratory parameters, white blood cells, neutrophils, creatinine, D-Dimer, ferritin, CRP values were observed to be significantly higher in Group 2 patients than Group-1 patients. However, lymphocyte count, serum potassium level, albumin and calcium levels were observed to be significantly lower in Group-2 patients than in Group-1 patients. SII level was significantly higher in Group 2 patients than Group-1 patients (1813.4 ±118.7 vs 978.2 ± 93.1, p
Cardiac Findings on Non-Contrast Thoracic Tomography in Patients with Acromegaly
Authors: KESKİN Lezan , ILGAR Mehtap , YAPRAK Bulent , AKÇİÇEK Mehmet , ASLANTÜRK Okan
Published: December 2022

Aim: Acromegaly occurs as a result of excessive and permanent secretion of growth hormone from the pituitary. Mortality is mostly related to cardiovascular system involvement. In our study, we aimed to evaluate the correlation between epicardial fat volume (EFV) and growth hormone level in thorax computed tomography in patients with acromegaly and coronary artery calcification, pulmonary artery diameter, ascending aorta diameter, cardiothoracic ratio (CTO) measurements with the control group patients.

Method: Our study was retrospective and included 16 patients with acromegaly who were previously diagnosed and treated by the endocrinology clinic and a control group consisting of 32 patients matched for gender and age.In thorax CT, EFV measurement of the patients was performed and main pulmonary artery diameters, ascending aorta diameters, cardio thoracic ratios, presence of coronary artery calcification were evaluated.

Results: The number of patients with large ascending aorta was higher in patients with acromegaly and it was statistically significant (p=0.041). Although the rate of patients with large main pulmonary artery diameter was higher in patients with acromegaly, no significant difference was found between the groups (p=0.355). There was no significant difference between the groups in terms of increased CTO (p=0.818) and coronary artery calcification (p=0.157).

Conclusion: In our study, a difference was found between the acromegaly and control group patients only in terms of ascending aorta diameters, but no significant difference was found in terms of other parameters. We think that regular follow-up and treatment of patients is effective in this result. Cardiovascular risks can be reduced in patients with acromegaly with early diagnosis, regular follow-up and treatment.
Risk Factors for 7-Day and 21-Day Mortality in Patients with Ventilator-Associated Pneumonia Caused by Gram-Negative Multidrug Resistant Bacteria
Authors: ODEMİS Ilker , VURAL TASDEMİR Elif
Published: December 2022

Objective: Incidence of ventilator-associated pneumonia, caused by gram-negative multidrug resistant bacteria, is on the increase and early mortality rate is high. We aimed to investigate the effects of aging, comorbidities, high Charlson comobidity index score, high Acute Physiology and Chronic Health Evaluation II score, leukocytosis, high C-reactive protein level, inappropriate empirical antibiotic therapy and antibiotic resistance on mortality in ventilator-associated pneumonia caused by gram-negative multidrug-resistant bacteria. Methods: The study was planned as a retrospective cohort study. Patients aged 18 years and older who were hospitalized between January 01, 2015, and January 01, 2020, diagnosed with ventilator-associated pneumonia, and had Gram-negative multidrug resistant pathogen was detected in blood and/or bronchoalveolar lavage fluid specimen or quantitative endotracheal aspirate cultures were included in the study. Results: A total of 370 patients were included in the study. Median age of the patients was 74 (19-95) years. Most frequent bacteria was Acinetobacter baumannii (52.4%). Resistance to ceftriaxone, meropenem, and colistin was 99%, 68%, and 4%, respectively. 7-day and 21-day mortality rates were 38.3% (n=142) and 85.1% (n=315). In multivariate analysis, 7-day mortality was associated with a Charlson comorbidity index score of ≥4, and risk factors for 7-day mortality were septic shock, amikacin resistance, and white blood cell count ≥15000/mm3. Advanced age was found to be a risk factor for 21-day mortality, and a high Acute Physiology and Chronic Health Evaluation II score and a high Charlson comorbidity index score were associated with 21-day mortality. It was found that the risk of 7-day mortality in patients with tracheostomy was lower than in patients without tracheostomy. Conclusion:Consideration of clinical scoring systems, closer monitoring of elderly patients, following-up with tracheostomy, may provide a decrease in mortality of ventilator-associated pneumonia, caused by multidrug resistant pathogens.
Valproik asidin ferroptozregülasyonu yoluyla C6 glioblastoma hücrelerinin canlılığı üzerindeki etkileri
Authors: HACIOĞLU Ceyhan , ÇORBACI Bahtiyar , CANAYAKIN Merve , GÜLER Özge , AĞMUR HAZAR Zeynep Y , YAKUPOĞLU Ece , CEYLAN Gizem , KÜTÜK Esra
Published: December 2022

Amaç: Glioblastoma (GBM) invaziv karakteriyle ortalama sağ kalım süresinin 1 yıl olduğu en ölümcül beyin tümörleri arasında yer alır. Cerrahi operasyon, radyoterapi ve kemoterapiyi içeren standart tedavi sonrasında bile nüksler çoğunlukla yeniden görülmektedir. Ferroptoz, demir bağımlı olarak farklı hücresel molekülleri hedef alan yeni tanımlanmış bir hücre ölümü şeklidir. Valproik asit (VPA), epilepsi tedavisinde kullanılan histondeasetilaz inhibitörü olan bir yağ asididir. VPA, nöroprotektif ve anti-tümör etkileri sayesinde in vitro ve in vivo modellerde tümör invazyonunu etkili bir şekilde baskılamaktadır. Bu çalışmada, C6 hücrelerinde VPA’nın ferroptoz uyarıcı bir ajan olarak antiproliferatif etkilerini araştırmayı amaçladık. Yöntemler: İlk olarak, sitoksik VPA konsantrasyonunu 3-(4,5-dimetiltiyazol-2-il)-2,5-difeniltetrazolyum bromür (MTT) analizi belirledik. Ardında, 24 saatlik VPA uygulamasıyla C6 hücrelerindeki glutatyonperoksidaz 4 (GPx4), 8-hidroksi-2'-deoksiguanozin (8-OHdG), glutatyon (GSH) ve malondialdehit (MDA) seviyelerini ELİSA yöntemiyle uygun kitler kullanılarak ölçtük. Bulgular: C6 hücreleri 0.1, 0.5, 1, 2, 4 ve 8 mM VPA konsantrasyonları ile 24 süreyle inkübe edildi. 1 mM ve üzerindeki VPA konsantrasyonlarında hücresel canlılıkta istatiksel olarak anlamlı düşüş olmuştur (p
Prematüre Bebeklerde Patent Duktus Arteriyozusun Cerrahi Kapatılması: Klip Uygulaması veya Sütür Ligasyonu
Authors: KILIÇ Yiğit , AKTİZ BIÇAK Esra
Published: December 2022

Amaç: Çalışmanın amacı, sol anterior mini torakotomi tekniği ile ile patent duktus arteriyozuslarına (PDA) klip aplikasyonu veya sütürligasyonu yapılan prematüre hastaların tek merkezli kısa dönem sonuçlarını bildirmektir. Yöntemler: Kasım 2020-Kasım 2021 tarihleri arasında aynı pediatrik kardiyovasküler cerrah tarafından opere edilen ve tek merkezde sol anterior mini torakotomi tekniği ile PDA’ları kapatılan 22 prematüre bebeğin verileri gözden geçirildi. Bulgular: Ortalama (±SD) gestasyonel yaşı 25.9 (±2.1) hafta ve ortalama doğum ağırlığı 1039 (±452) gr olan 22 hasta sol anterior mini torakotomi tekniği ile opere edildi. En düşük vücut ağırlığı 600 g idi. 11 hastada PDA'ya klip yerleştirildi ve 11 hastada PDA 2-0 ipek sütür ile bağlandı. Olgular arasında kan kaybı, cerrahiye bağlı mortalite veya operasyon süresi açısından anlamlı fark yoktu. Ameliyat sonrası 8 ölüm (%36) oldu. Postoperatif ilk 30 günde 7 (%31,8) ölüm, postoperatif birinci ay ile birinci yıl arasında 1 (%4) ölüm vardı. Ölümlerin nedeni sepsis, NEC, hidropsfetalis, hepatoblastom ve kafa içi kanama idi. Gruplar arasında morbidite ve komplikasyon oranlarında istatistiksel olarak anlamlı fark yoktu. Sonuç: Prematüre bebeklerde PDA kapatılması için sol anterior mini-torakotomi ile klip uygulaması ve sütürligasyonu yaklaşımları arasında kan kaybı, operasyon süresi, morbidite, komplikasyon ve cerrahiye bağlı mortalite açısından anlamlı bir fark olmadığı görüldü.
Akne Vulgaris Tanılı Erişkinlerde Hastalık Şiddetinin Depresyon, Anksiyete, Beden Algısı, Uyku Kalitesi, Cinsel İşlevler ile İlişkisi ve Tedavi Sonrasındaki Değişimi
Authors: YILBAŞ Barış , YILDIRIM Fatmaelif
Published: December 2022

Amaç: Bu çalışma, akne vulgaris tanılı erişkenlerde hastalık şiddetinin bireylerin depresif yakınmaları, anksiyete belirtileri, beden algıları, uyku kaliteleri ve cinsel işlevler ile ilişkisini incelemeyi amaçlamaktadır. Ayrıca rutin ilaç tedavileri sonrasında bu parametrelerdeki değişimin incelenmesi hedeflenmektedir.

Yöntemler: Çalışmamıza 46 gönüllü dahil edilmiştir. Katılımcılara AV tanısıyla başlanan rutin ilaç tedavileri öncesinde sosyodemografik veri formu, Hastane Anksiyete ve Depresyon Ölçeği, Vücut Algısı Ölçeği, Arizona Cinsel Yaşantılar Ölçeği (ACYÖ), Pittsburgh Uyku Kalitesi İndeksi (PUKİ) ve Akne Yaşam Kalitesi Ölçeği (AYKÖ) uygulanmıştır. Ayrıca gönüllülerin akne şiddetini belirlemek amacıyla ilk tanı aldıklarında Global Akne Derecelendirme Sistemi (GADS) kullanılmıştır. Çalışmamızın ikinci aşamasında üç aylık rutin ilaç tedavisi kullanan gönüllüler ilk aşamada uygulanan ölçeklerle tekrar değerlendirilmiştir. Araştırmanın ikinci aşamasını 20 gönüllü tamamlamıştır.

Bulgular: Çalışmaya katılan gönüllülerin yaş ortalaması 23.80±4.5 yıl idi. Gönüllülerin 33’ü (%71.7) kadın, 13’ü (%28.3) erkekti. Çalışmamızdaki gönüllülerin GADS ortalama puanları 18.21±6.75 idi. Uygulanan ölçeklerin GADS puanı ile ilişkisi Pearson korelasyon analizi ile incelendi. Buna göre GADS puanıyla AYKÖ skorları arasında pozitif yönde korelasyon mevcuttu (r=0.655, p
HIV ile Yaşayan Bireylerde İmmunolojik ve İnflamatuar Belirteçler ile Karotis Arter İntima-Media Kalınlığı Arasındaki İlişkinin Araştırılması
Authors: DAMAR ÇAKIRCA Tuba , GÖKTEPELİ Mehmet , BAL Tayibe
Published: December 2022

Amaç: Bu çalışmada HIV ile yaşayan bireylerde (HİYB) immünolojik belirteçler olan CD4, CD8, CD4/CD8; inflamatuar parametrelerden C-reaktif protein (CRP), Eritrosit sedimentasyon hızı (ESH), prokalsitonin, D-dimer; hemogram sonuçlarından elde edilen nötrofil/lenfosit oranı (NLR), platelet/lenfosit oranı (PLR) ve CRP/lenfosit oranı (CLR) değerleri ile karotis arter intima-media kalınlığı (CIMT) arasında ilişki olup olmadığının belirlenmesi amaçlanmıştır.

Yöntemler: Bu kesitsel, tek merkezli çalışmaya Haziran 2020- Kasım 2021 tarihleri arasında merkezimizde takipli, 18-40 yaş aralığında olup ek hastalığı (obezite, kardiyovasküler hastalık, diyabetes mellitus, hipertansiyon) olmayan, antiretroviral tedavi (ART) alan, HIV-RNA’sı negatif olan (viral suprese) 49 HİYB dahil edildi. Hastaların demografik, antropometrik ve laboratuvar verileri kaydedildi. Her hastanın CIMT ölçümü B-mode Ultrasonografi ile yapıldı. Subklinik ateroskleroz için CIMT cut-off değeri 0.9 mm kabul edildi.

Bulgular: Olguların medyan ART kullanım süresi 19 (8-43) ay, medyan CD4 sayısı 605 (438-913) hücre/μL, sağ CIMT ölçüm medyan değeri 0.48 mm (0.42-0.58) ve sol CIMT medyan değeri 0.46 mm (0.41-0.58) olarak saptandı. Hiçbir hastada plak formasyonu gözlenmedi. Medyan CIMT ile ART kullanım süresi arasında pozitif ve düşük orta düzeyde (rho=0.341, p=0.016), medyan CIMT ile yaş arasında ise pozitif ve orta düzeyde bir korelasyon saptandı (rho=0.517, p
Prediction of Cognitive Decline by Behavioral Symptoms in Neuropsychiatric Disorders
Authors: Barekatain Majid , Sadeghpour Sona , Rajabi Fatemeh , Maracy Mohammad Reza
Published: December 2022

Background: Neuropsychiatric disorders are described by their neurological, behavioral, and cognitive symptoms. However, behavioral symptoms may often be overlooked due to the current approach in neurology. Objectives: This study investigated the relationship between behavioral symptoms and cognitive functioning in neurological disorders. The second aim was to predict neurocognitive patterns by behavioral symptoms as independent variables. Methods: Behavioral symptoms were collected based on semi-structured neuropsychiatric interviews with 211 patients admitted to the neuropsychiatry department of Ayatollah Kashani hospital in Isfahan by both a neuropsychiatry fellow and an attending neuropsychiatrist. A neuropsychiatry fellow assessed all patients using the neuropsychiatry unit cognitive (NUCog) assessment tool. We used a generalized linear model (GLM) to indicate the effect of behavioral symptoms on the risk of decline in cognitive domains. Due to the use of all available samples, this study had no age limit, and the patients were 15 to 92 years old. Results: The regression coefficient of NUCog subscale scores for behavioral symptoms using GLM revealed that education level had a positive relationship with the scores of attention (P < 0.001), visuoconstruction (P < 0.001), memory (P < 0.001), executive function (P < 0.001), language (P < 0.001), and the total score of NUCog (P < 0.001). Patients with apathy had lower scores on the memory subscale (P = 0.002) and total NUCog (P = 0.021). Similarly, patients with delusion had lower scores on memory (P = 0.006) and executive function (P = 0.026). There was a negative relationship between agitation and attention (P = 0.049), visuoconstruction (P = 0.015), memory (P = 0.018), executive function (P = 0.005), and total score of NUCog (P = 0.007). Sleep disturbances were accompanied by lower memory scores (P = 0.056) and lower mean NUCog scores (P = 0.052). Visual hallucination was associated with declined performance in attention (P = 0.057). Conclusions: Behavioral assessment can help predict cognitive patterns in patients with neurobehavioral syndromes.
Diminutif ve Küçük Kolorektal Poliplerde Kanser Riskinin Değerlendirilmesi
Authors: DEMİR Nurhan
Published: December 2022

Amaç: Çapı <10 mm olan kolorektal poliplerin tedavisi tartışmalıdır. Çalışmamızın amacı, diminutif (≤5 mm) ve küçük poliplerin (5 – 9 mm) histopatolojik özelliklerini gözden geçirmek ve kolonda <10 mm çapındaki polipler için ileri adenom prevalansını değerlendirmektir. Materyal ve Metod: Endoskopi ünitemizde kolonoskopi yapılan 2312 hastanın tıbbi kayıtları geriye dönük olarak incelendi. Histolojik olarak villöz / tubulovillöz polip, yüksek dereceli displazi veya intramukozal karsinom olarak tanımlanan ilerlemiş adenom varlığını incelendi. Bulgular: Hastaların 448’inde toplam 653 polip tespit edildi ve %90,8 (593/653) oranında polip<10 mm büyüklüğündeydi. Boyutları 10 mm'den küçük 386 konvansiyonel adenom vardı ve bunların 376'si tübüler adenomdu. Adenomatöz olmayan 211 polip vardı ve bunların 162’si hiperplastik polipti. Tüm konvansiyonel adenomların 7'sinda, boyutu ≤5 mm olan adenomların 2 tanesinde ve 6-9 mm boyutundaki adenomların 2 tanesinde yüksek dereceli displazi vardı. Tüm adenomlardan ≤5 mm boyutundakilerin %0.8'i ve 6-9 mm boyutundakilerin %1.65'i advance adenomdu. Boyutları ≤5 mm olan 472 polip ve 6-9 mm boyutlarındaki 121 polipten hiçbirinde kanser saptanmadı.Sonuç: İleri histolojik displastik özelliklerin genel prevalansının diminutif kolon poliplerinde %0,8 ve küçük poliplerde %1.65 bulundu. Diminutif kolon poliplerinde ileri histolojik displastik özellik prevalansı çok düşüktür (%0.8). Mevcut çalışma, Diminutif polipler arasında rezeksiyon ve atma stratejisini destekler nitelikteydi.
An Evaluation of Cardiovascular Risk Factors Among Military Personnel: A Study Conducted in Turkey
Authors: GÜNLÜ Serhat , KARAHAN Mehmet Zülkif
Published: December 2022

Background: Cardiovascular (CV) risk factors are associated with high morbidity and mortality rates; however, prevalence data for Turkish military members are unknown.
Aim: This study determines how common cardiovascular risk factors are among military members in the Corps Command Military Unit and how they relate to socio-demographic parameters.
Materials and Methods: A cross-sectional research was conducted with 25222 active-duty individuals. A questionnaire was used to assess cardiovascular risk factors. This study included patients with more than two risk factors or current cardiac complaints. ECGs, echocardiograms, and biochemical testing were performed.
Results: The study employed 835 individuals with an average age of 19.43±2.12 years. 19.6% of them had hypertension, 5.6% had dyslipidemia, 39.6% were smokers, 2.4% had diabetes mellitus, and 9.8% had a positive family history. Physical activity frequency was not observed in 54% of the patients before enlisting in the military. There was a significant positive correlation between smoking and mental stress (r=1.07, p<0.001).
Conclusion: In terms of cardiovascular risk, hypertension and smoking were found to be the most prevalent among the Corps command staff. Therefore, this study provides compelling evidence that military healthcare providers should conduct annual periodic checks on those at risk for cardiovascular diseases.
Análisis del nivel de adaptación socioemocional y su relación con el rendimiento en el alumnado de primaria
Authors: Martínez-Álvarez Isabel , Hidalgo-Fuentes Sergio , Sospedra-Baeza María José
Published: December 2022

Este trabajo evalúa los resultados de un programa para la mejora de la adaptación socioemocional del alumnado. Se analiza, por un lado, el perfil socializador (construido en base a las competencias socioemocionales desarrolladas en el programa) y su relación con el rendimiento académico y, por otro, la existencia de diferencias de género en dicho perfil. Participaron 198 estudiantes de educación primaria (103 varones (52%) y 95 mujeres (48%) –M= 8.68 años; DT= 1.75-) y 18 docentes (5 varones (28%) y 13 mujeres (72%) –M= 48.83 años; DT= 4.27-). Se aplicó la batería de socialización BAS-1. Se utilizó metodología descriptiva, comparativa y correlacional. Se realizaron análisis descriptivos, comparativos, de correlación y de regresión lineal múltiple. La muestra presenta un perfil de socialización altamente facilitador, que se relaciona con el rendimiento académico. Se encontraron diferencias en los aspectos facilitadores de la socialización a favor de las niñas, mientras que, en los aspectos inhibidores, únicamente se detectaron diferencias en agresividad-terquedad, siendo superior en los niños. Esta investigación apunta hacia la eficacia y pertinencia del programa debido a los efectos positivos detectados.
La satisfacción laboral en las relaciones interpersonales del profesorado de educación no universitaria, su relación con situaciones de acoso o maltrato y exploración de predictores personales y contextuales
Authors: González Álvarez María
Published: December 2022

El presente trabajo tiene como objetivo realizar un estudio exploratorio de la satisfacción laboral del profesorado no universitario en sus relaciones interpersonales y posibles situaciones sufridas de acoso, maltrato o agresión, según variables sociodemográficas y de cargos de responsabilidad en los centros. Se realizó una consulta on line entre el profesorado de las diferentes comunidades autónomas de España, mediante un protocolo elaborado ad hoc y que fue cumplimentado por 2738 docentes. El cuestionario tiene un coeficiente de fiabilidad de Cronbach de 0,862. Se realizaron análisis descriptivos, diferencia de medias y análisis multivariado. Entre las conclusiones obtenidas destacan que el profesorado manifiesta tener una satisfacción media-alta en sus relaciones con los cargos directivos, profesorado y alumnado, una satisfacción media con las familias y media-baja con la administración y la inspección educativa. Respecto a las posibles situaciones de acoso, maltrato o agresión sufridas por el profesorado es elevado el porcentaje que manifiesta haberlas padecido. Parece adecuado seguir analizando la satisfacción del profesorado en sus relaciones interpersonales y procede investigar de manera urgente las situaciones de acoso, maltrato o agresión sufridas por el profesorado.
Analisis Sistem Pentanahan pada Jaringan Tegangan Rendah di Gedung Mal Jayapura
Authors: Suwarna Ating Prihatin
Published: December 2022

Pendahuluan: Sistem pentanahan atau disebut juga Arde atau grounding adalah sistem yang berhubungan antara penghantar arus listrik yang menghubungkan sistem dengan peralatan dan instalasi dan dihubungkan ke bumi (Ground) sehingga apabila terjadi kebocoran arus dapat mengamankan manusia (Human) dari sengatan listrik, dan mengamankan komponen komponen instalasi dari bahaya tegangan/arus abnormal. Tujuan: Menganalisa sebab penyimpangan nilai Tahanan tanah sehingga bisa berubah ubah nilai tahanannya. Melakukan Analisa dan simulasi peralatan Proteksi pentanahan untuk mengetahui batas Treshhold bawah dan threshold atas pada peralatan tersebut. Metode: Berdasarkan data–data primer yang penulis peroleh yang merupakan variable variable berbentuk data numerik, maka metode yang penulis tentukan disini adalah Metodologi Kuantitatif. Hasil: Secara teori untuk tanah pada kondisi tanah yang sama, semakin dalam penanaman elekroda, tahanan tanah dan tahanan jenis tanah akan menurun karena semakin dekat dengan air tanah yang berpengaruh dengan kelembaban yang nantinya berpengaruh terhadap konduktivitas. Kesimpulan: Baru-baru ini, permintaan bahan alami meningkat. Hal ini dikarenakan bahan baku yang banyak, murah, dan mudah disiapkan. Kelemahan dari bahan tembaga konvensional seperti korosi telah disorot. Dengan demikian, bahan-bahan lanjutan telah diperkenalkan untuk mengatasi masalah ini. Selain itu, pembentukan fulgurit dihasilkan ketika impedansi pentanahan dikenai suplai tegangan tinggi
An Assessment of the Impact of Round Wood Collection on Deforestation in Benue State, Nigeria
Authors: Akpa Amona Adah , Onuh Sixtus Samuel , Kabuk V Elias , Julian Chukwuemeka Ibe
Published: December 2022

Purpose: The high cost of alternative sources of household energy and steel in Nigeria is aggravating the dependence on forest frontiers in search of forest wood for construction, charcoal production, and fuel wood gathering for heating. This necessitates the study to access the impact of Round Wood Collection (proxies as Tree Logging, Charcoal Production, and Fuel Wood Collection) on Deforestation in Benue State, Nigeria.

Methodology: A survey design research was used for the study with the instrument of a structured questionnaire administered to 400 respondents determined by Taro Yamane’s (1967) sampling formula and selected through two-stage sampling techniques across nine (9) Local Government Areas (LGAs) in Benue State. The data elicited from the field was analyzed through descriptive statistics and a regression with the aid of Statistical Package for Social Science (SPSS) 23.

Findings: The result showed a significant positive relationship between Round Wood Collection (RWC) and Deforestation (DEF) in Benue State, implying that DEF in Benue State will increase significantly by 24.4%, 44.7%, and 28.4% as a result of a percent change in the rate of Tree Logging, Charcoal Production, and Fuel Wood Collection respectively in the state.

Conclusion: The study concludes that RWC impacts negatively on the forests and vegetation cover in Benue State which has a negative ripple effect on biodiversity, the ozone layer, ecosystem functioning, and livelihoods of forest fringe communities.

Recommendation: The study recommends that the Benue State government should increase funding to the State Department of Forestry and employ adequate forest personnel to enhance forest management and revenue yields from the forests.
Ex Ante Allusions
Authors: Holt Jason
Published: December 2022

We tend to think of allusions as indirect references to objects that already exist. Here I argue against this post facto orthodoxy and for the view that certain cases of allusion count as ex ante allusions (i.e. allusions before the fact). I argue that the standard view conflates the epistemic dependence of allusion (knowledge of the object of allusion) with an existential dependence (the object must already exist). As an adequate account of allusion should explain both the apparent paradoxical character and the possibility of ex ante allusions, I propose that literary allusions should be understood in terms of what might be called reference from rather than reference to.
Persistent Autonomy and Romanticism
Authors: Doorman Maarten
Published: December 2022

Autonomy in the arts is generally considered an outdated concept, an atavism that is only relevant to outsiders and to people who have a mere traditional, if not completely obsolete understanding of the artistic and aesthetic field. Autonomy in this view has little to do with contemporary discussions about art and artistic practices. The very first sentence of a recent study about autonomy in literature, Andrew Goldstone’s Fictions of Autonomy (2013) for example reads: ‘In literary studies, we regard aesthetic autonomy as an idea whose time has passed.’

Instead of repeating the historicity and irrelevance of the autonomy concept it may be interesting to ask why it has been criticised so often while continuing to reappear again and again. If we keep in mind Peter Bürger’s analysis in his classic Theory of the Avant-Garde (1984), that the Avant-Garde failed to abolish autonomy in the arts and that this appeared to be impossible in what he calls ‘late capitalist society’, it may still be worthwhile to ask ourselves, how to understand the tenacious belief in autonomy, a belief that has so often been abolished yet and is still present everywhere. In doing so we’d better go back to the emergence of the belief in autonomy in the art history of the last few centuries rather than adding still another explanation about the irrelevancy of the concept.
The Cognitive Value of Blade Runner
Authors: McGregor Rafe
Published: December 2022

The purpose of this essay is to argue that Blade Runner: The Final Cut (Ridley Scott, 2007) has cognitive value which is inseparable from its value as a work of cinema.  I introduce the cinematic philosophy debate in §1.  §2 sets out my position: that the Final Cut affirms the proposition there is no necessary relation between humanity and human beings.  I outline the combination of cinematic depiction with distinctive features of the narrative’s peripeteia in §3.  In §4, I explain the cognitive value of the peripeteia.
The Question of Literary Realism
Authors: Farina Mario
Published: December 2022

The aim of this paper is to investigate the notion of literary realism both in contemporary debate and in aesthetic reflection of nineteenth Century. What I intend to show, in fact, is the possibility to exploit some conceptual tools developed during the last century in the context of German literary aesthetics in order to give an answer to a set of problems deeply bounded to the contemporary discussion. Therefore, I intend to present Theodor Wiesengrund Adorno’s notion of “literary realism” as a possible solution to some problematic refrains in the philosophical investigation of literature. To this aim, I’ll divide my argument in three steps: first of all, I’ll sketch out the basic lines of the historical debate about realism in novels; secondly, I’ll outline Adorno’s notion of realism; thirdly, I’ll try to show to what extent Adorno’s definition could provide an answer to recurring issues in current debates.
Inaugurating Philosophy of Film Without Theory
Authors: Fox Craig , Harrison Britt
Published: December 2022

Philosophy of film without theory is a methodology that aims to motivate and legitimise the current and future development of a range of a-, non-, and anti-theoretical ways of working at the intersection of film and philosophy. We contrast philosophy of film without theory with the main traditions of theoretically orientated philosophy of film, as well as philosophically inflected film Theory and film-philosophy. We also draw attention to the range of philosophical practices and pursuits that distinguish philosophy (in general) without theory and contemporary philosophy (in general) with its near ubiquitous theoretical presumption.  The paper finishes with a brief introduction to the various contributions to this Special Issue of Aesthetic Investigations on Philosophy of Film Without Theory.
Sensus and Dissensus Communis
Authors: Früchtl Josef
Published: December 2022

The thesis of the article is that within the framework of Western culture the cinematic comedy again and again can be seen as an aesthetic form where passions for democracy take their way. Following Cavell, philosophy, first, is as a matter of the "human voice" which is, in reference to Kant's third Critique, a "universal voice". The aesthetic judgement insofar is a model of philosophical and, secondly, of democratic judgement. For in Kant, arguing about aesthetic matters means facilitating the communitarisation of confrontation. "Common sense" (sensus communis) is the political term Kant offers for this. Since this term, thirdly, has recently again been appropriated by populist semantics, it is important to stress a radically democratic, with Cavell: a romantic conception of democracy, and to this conception, fourth, the art form of comedy corresponds. Comedy and democracy both  centre around "the common, the familiar, the low", and in laughter give this human-social sphere both an anarchic-democratic level of meaning and a certain, humorous self-reflection. The movie Adam's Rib finally works as an example for this.
Análise dos efeitos do ambiente de operações e do poder de mercado da firma na posição competitiva de firmas brasileiras
Authors: Dias Alexandre Teixeira , Camargos Marcos Antônio de , Falcão Nidelson Teixeira , Matos Pedro Verga
Published: December 2022

Objetivo: Este estudo tem por objetivo analisar os efeitos que o ambiente competitivo e o poder de mercado da firma exercem na posição competitiva de firmas, no período de 2012 a 2017, que abarca os efeitos da crise de 2008.Desenho/metodologia/abordagem: Os parâmetros do modelo estrutural foram estimados por meio de modelagem de caminhos com mínimos quadrados parciais. O tamanho da firma foi utilizado como fator de ponderação. A amostra é composta por firmas brasileiras de capital aberto, atuantes na indústria manufatureira e ativas no período de 2012 a 2017.Resultados: A capacidade das firmas de alcançar e sustentar uma posição competitiva favorável é dependente do seu poder de mercado. Sob uma perspectiva gerencial reativa, gestores devem fazer escolhas estratégicas que permitam à firma se manter próxima aos consumidores, e manter e reforçar o seu poder de mercado, evitando reduções em sua participação de mercado. Sob uma perspectiva gerencial proativa, os gestores devem tirar vantagem do poder de mercado, com o estabelecimento de barreiras que dificultem o acesso dos concorrentes aos consumidores.Originalidade/valor: Esta pesquisa apresenta duas contribuições originais. A primeira delas é a identificação dos fatores determinantes da posição competitiva de firmas brasileiras, durante o período após a crise financeira de 2008. A segunda é a proposição e o teste de um modelo de equações estruturais, com o objetivo de estimar os efeitos do poder de mercado e do ambiente competitivo, na posição competitiva da firma.
UX Design e nomofobia: desenvolvimento de um assistente facilitador do uso saudável de smartphones
Authors: Mülling Tobias Tessmann , Cardozo Arthur
Published: December 2022

Ambientada na temática do uso excessivo de smartphones, esta pesquisa aborda, a partir de uma revisão bibliográfica, temas relacionados a causas e consequências de tal uso aditivo e a relação do design – em especial a experiência do usuário (UX) – como mediador deste processo de consumo. Na sequência, através da metodologia de Duplo Diamante, foi desenvolvida uma proposta de incremento para a ferramenta “Bem-estar digital” do sistema operacional Android, visando incentivar uma mudança mais gradual no consumo de aplicativos de smartphones. Como resultado, obteve-se um protótipo navegável que foi submetido a um teste de usabilidade de caráter formativo, indicando um potencial de uso satisfatório da proposta desenvolvida.
North American Migrants Working as Tour Guides in Alamos in Mexico Mobilities and Imaginaries
Authors: Clausen Helene Balslev
Published: December 2022

The article focuses on the guide’s narratives and practices when guiding “HouseTours” that is the most visited tourist attraction in the Mexican town. We argue thatthese guides provide narratives about concrete imaginaries that constitute not onlyauthenticity but also utopia – that we consider one of the core elements in tourismimaginaries. The guides inscribe themselves in the utopian imaginaries in the Westernhemisphere that continue to be essential in the socio-cultural and political constructionof society. We conclude that these tourism imaginaries of places (and people) cannotbe considered only as commoditized representations with a symbolic content. Alamosdisplays that way the significant connections that exist in terms of both representationsand mobilities.
Recuerdo y memoria, componentes esenciales en tres cuentos de Juan José Saer
Authors: Mellerup Susana Ester
Published: December 2022

Memory is probably one of the most important and hotly debated of our mental functionsand as such it is the subject of many different theoretical viewpoints, an object of studyupon which a wide variety of analytical tools have been used, including psychoanalysis,neurology, literature, etc. In this essay, I will examine the work of literary author Juan JoséSaer, many of whose narrative fictions have memory (memoria) and recollection (recuerdo)as central themes. I will investigate the role of memory and recollection in some of Saer’snarratives, and at the same time explore conventional assumptions about the relationbetween past, present, and future, as seen through the lens of memory and recollection. Iwill approach the topic first from the point of view of semiotician Per Aage Brandt andlater employing the theoretical work of Tzvetan Todorov’s “Los abusos de la Memoria”,Antonio Muñoz Molina’s “Memoria y Ficción” and José Antonio Marina’s “La memoriaCreadora”.
A Economia como um capítulo da Ecologia
Authors: Pereira Elenita Malta
Published: December 2022

The present article aims at discussing Brazilian agronomist José Lutzenberger’s appropriation of authors from the ecological economics field to construct his environmental discourse, so as to fixate a human ethics in relation to nature. Based on such authors, he made an important critique on the current economic system, particularly what he called the “economic growth dogma”. Moreover, he defended a stable State economy, based on the concept of homeostasis and without the obligation to growth. This economic model, in his view, by imitating the modus operandi of ecosystems, not generating waste or environmental degradation, would in turn create a fairer economy both to the natural elements and to human societies.
“La Plata Llega Sola”
Authors: Ioris Antonio A. R.
Published: December 2022

Corruption is a global problem that feeds on national and localopportunities. Instead of the prevailing attempts to reduce anti-corruptionstrategies to the protection of business interests, corruption needs to be seenas a sociopolitical relation that emanates from the convergence betweenmore immediate circumstances and long-term institutional tendencies.Corruption is, therefore, a phenomenon with synchronic and diachronicdimensions. The complexity of corruption is examined in relation to theorganization of Peruvian state and society, in particular considering therecent liberalization reforms and investments in the water industry of Lima.The Peruvian case study shows how corruption becomes a productive forcefrom the perspective of conservative elites and the maintenance of politicalhegemony.
A mão invisível de Deus: sobre a aliança entre liberais e conservadores na nova direita brasileira
Authors: Wink Georg
Published: December 2022

Este trabalho examina como uma base comum de pensamento vem facilitando a aliança entre liberais e conservadores na atual conjuntura política do Brasil, possibilitando a ascensão de uma nova direita, que chegou ao poder em 2018. Argumenta-se que o pensamento liberal, desde à sua introdução no Brasil, se articula eficientemente com o conservadorismo para preservar o status quo social, entrando em ação em momentos de possível reforma social, especialmente pela doutrinação de tomadores de decisão e formadores de opinião através de uma rede amplificada de think tanks. A análise demonstra a existência de uma proximidade de pensamento que se alimenta discretamente de uma dimensão liberal no conservadorismo, a redescoberta da tradição liberal da escolástica medieval, e de outra religiosa no liberalismo, no Brasil inspirado na Escola Austríaca de Economia. Desta forma, possibilita a promoção de um novo utopianismo liberal-conservador velado e persuasivo que camufla, ao mesmo tempo, seu caráter utópico e escatológico.
Merleau-Ponty reader of Goldstein: what is organismic intentionality?
Authors: Müller Marcos José
Published: December 2022

Abstract: The present study proposes an investigation into the reasons why Merleau-Ponty recognizes, in Goldstein’s incorporation of the figure-ground notion from the Gestalt Psychology, the convergence between contemporary science and phenomenological philosophy. It is about understanding how, insofar as it reveals the power of centering that operates in the concreteness of the existence of organisms in the surroundings, the notion of figure-background corresponds to the phenomenological notion of operative intentionality. In the same way, it is a matter of showing in what sense, as a form of operative intentionality, the power of centering of organisms does not need to be based on the presupposition of an “I think”.

Keywords: Merleau-Ponty; Goldstein; Gestalt; organismic intentionality
Neither Theory nor Science Metaphilosophical Remarks on Philosophical Elucidations
Authors: Reinoso Guadalupe
Published: December 2022

This article examines Wittgenstein’s philosophical reflection on philosophy: its method, its scope, and its relationship with other knowledge as central elements of the philosophical proposal the author developed in Tractatus Logico-Philosophicus. Therefore, my proposal is to rehearse a metaphilosophical reading of Wittgenstein’s remarks about philosophy in TLP focusing, on the one hand, on his reflections on philosophy as an activity and not as a theory; on the other hand, on his categorical differentiation established between philosophical elucidations and scientific explanations.

This proposal differs from the readings that interpret it is through the construction of a theory of meaning -or logical doctrine- that one can distinguish philosophical nonsense and see the world correctly. It also differs from Tractatus’s non-theoretical or quietist readings which understand philosophical elucidations as exclusively negative or critical nonsense. My aim is to highlight a positive aspect of philosophical elucidations that I will call performative. From my metaphilosophical reading, not only does the activity of clarification work as a critical sieve that separates what makes sense from what does not –with no theory; but it also makes a modification -a transformation- in the one who establishes it. These performative aspects imply emphasizing that there is a change in the way we see the world but also in the way we ‘see’ language, meaning, logic, science, philosophy, life, etc. Thus, the refusal to elaborate a theory or to offer scientific explanations does not turn the philosophical elucidations in TLP into a mode of self-destructive attack on all kinds of philosophy. On the contrary, these elucidations are part of the defense of a particular way of practicing it.
"School cinema" of the mid-1970s: "education of feelings" and love discourse (on the example of the film "One Hundred Days after childhood")
Authors: Smirnov Aleksei , Bezzubova Olga Vladimirovna
Published: December 2022

The object of the study is the movie "One Hundred Days after Childhood", one of the most famous Soviet films of the mid-1970s, dedicated to school and schoolchildren (the so-called "school cinema"). The subject of the study is the cultural meanings new to this genre, broadcast by the film, the phenomena of Soviet culture that made this broadcast possible and significant for Soviet cinema, as well as the expressive means of the film, indicating changes in Soviet culture and, in particular, in pedagogical strategies compared with the early 1960s ("thaw era"). The purpose of the study was to identify the role played by this film in the development of the theme of the school in Soviet cinema, as well as to establish those trends in Soviet culture of the 1960s and 1970s that made this development possible. As the main research method, a theoretical and cultural analysis of the most significant elements of the plot was used, representing both the key ideas of the Soviet "school cinema" and the most significant phenomena for Soviet culture of the 1960s and 1970s. As a result of the study, the role of classical Russian literature in the education of the most significant human qualities of Soviet schoolchildren for the period under consideration was established. In addition, the very fact of the appearance of this film suggests that the model of socialization peculiar to the Soviet school up to the early 1960s has lost its relevance, and the new model was still in the formative stage.
The Place of Intangible Cultural Heritage in the State Policy of China
Authors: Popova Anastasiia , Fomenko Evgeniia
Published: December 2022

The object of this research is the intangible cultural heritage of the People's Republic of China (NPC), the subject is the state policy in the field of protection of monuments of intangible cultural heritage. The article analyzes the approach of the Government of the People's Republic of China to the definition of the essence of the national intangible cultural heritage on the materials of legal documents, considers the classification developed in accordance with national, historical, cultural characteristics for the typologization of intangible cultural heritage objects. To improve the protection of intangible cultural heritage, the State Council of the People's Republic of China provides for a four-level hierarchy of monuments of the National Heritage: national, provincial, city and county, which contributes to more thorough and effective work with them. Particular attention is paid to the consideration of concepts that allowed China to fully integrate the protection of intangible cultural heritage into the modern political course of the state. The novelty and relevance lies in the study of the fundamental principles that guide the State Council of the People's Republic of China in its work on the study of intangible cultural heritage objects, the creation of their nomenclature base, the promotion of digital transformation in meeting the needs of the public in understanding the importance and uniqueness of cultural heritage. An important contribution is the analysis of approaches to ensuring the transfer of spiritual culture, the creation of favorable conditions for the support of "representative heirs" of China's spiritual culture. The main conclusion of the study is that as a result of the measures taken in China, progress has been made not only in the protection of intangible cultural heritage, but also in strengthening cultural awareness, spreading knowledge about the objects of the ICH, the development of traditional crafts, the study and popularization of traditional spiritual culture.
OPA1 supports mitochondrial dynamics and immune evasion to CD8+ T cell in lung adenocarcinoma
Authors: Wang Ying , Li Yadong , Jiang Xuanwei , Gu Yayun , Zheng Hui , Wang Xiaoxuan , Zhang Haotian , Wu Jixiang , Cheng Yang
Published: December 2022

Background

Mitochondrial fusion and fission were identified to play key roles during multiple biology process. Thus, we aim to investigate the roles of OPA1 in mitochondria fusion and immune evasion of non-small cell lung cancer cells.

Methods

The transcriptional activation of genes related to mitochondrial dynamics was determined by using multi-omics data in lung adenocarcinoma (LUAD). We elucidated the molecular mechanism and roles of OPA1 promoting lung cancer through single-cell sequencing and molecular biological experiments.

Results

Here, we found that copy number amplification of OPA1 and MFN1 were co-occurring and synergistically activated in tumor epithelial cells in lung cancer tissues. Both of OPA1 and MFN1 were highly expressed in LUAD tumor tissues and OPA1 high expression was associated with poor prognosis. In terms of mechanism, the damaged mitochondria activated the apoptotic signaling pathways, inducing cell cycle arrest and cell apoptosis. More interestingly, OPA1 deficiency damaged mitochondrial dynamics and further blocked the respiratory function to increase the sensitivity of tumor epithelial to CD8+ T cells in non-small cell lung cancer.

Conclusions

Our study demonstrated the high co-occurrence of copy number amplification and co-expression of OPA1 and MFN1 in LUAD tissue, and further revealed the contribution of OPA1 in maintaining the mitochondria respiratory function and the ability of immune evasion to CD8+ T cells of LUAD.
Market Integration and Price Transmission Analysis of Onion in Wholesale Markets of India
Authors: Kumar Mohit , Shaikh A. S. , Sharma Rohit Kumar
Published: December 2022

The present study was done in seven major onion wholesale markets in India, namely Pimpalgaon, Lasalgaon, Solapur, Pune, Bangalore, Hyderabad and Indore to explore the interdependence of wholesale prices amongst Indian onion markets. The study was conducted in all India perspective and the study period involves the seventeen years data of onion wholesale prices (January 2004 to December 2020). The study was majorly based on the prices of onion obtained through secondary source. These data were collected from various portals such as FAO, NHRDF, Agmarknet and NHB. The current study employs co-integration analysis of wholesale monthly onion prices in selected marketplaces to determine the degree of market integration. The Trace and Maximum Eigen-value tests results showed that the onion prices in India moves together in the long run equilibrium. As a result, it may be stated that India's onion markets are well-functioning. The direction of information flow was determined by using Granger Causality test. It was found that in few markets pairs, price transmissions were bi-directional whereas between Bangalore and Pune market, no transmission was found. The study reveals that Lasalgaon market is dominating in terms of price determination. The empirical study also recommends keeping a careful eye on diverse market behavioural patterns, since "news" in one market might have an influence on other markets due to the numerous interdependencies.