bluuebunny/crossref_metadata_2025 huggingface dataset:
Kinetic pathway of HIV-1 TAR cotranscriptional folding
Authors: Jin Lei , Zhang Sicheng , Song Zhenwei , Heng Xiao , Chen Shi-Jie
Published: May 2024

The Trans-Activator Receptor (TAR) RNA, located at the 5′-end untranslated region (5′ UTR) of the human immunodeficiency virus type 1 (HIV-1), is pivotal in the virus’s life cycle. As the initial functional domain, it folds during the transcription of viral mRNA. Although TAR’s role in recruiting the Tat protein for trans-activation is established, the detailed kinetic mechanisms at play during early transcription, especially at points of temporary transcriptional pausing, remain elusive. Moreover, the precise physical processes of transcriptional pause and subsequent escape are not fully elucidated. This study focuses on the folding kinetics of TAR and the biological implications by integrating computer simulations of RNA folding during transcription with nuclear magnetic resonance (NMR) spectroscopy data. The findings reveal insights into the folding mechanism of a non-native intermediate that triggers transcriptional pause, along with different folding pathways leading to transcriptional pause and readthrough. The profiling of the cotranscriptional folding pathway and identification of kinetic structural intermediates reveal a novel mechanism for viral transcriptional regulation, which could pave the way for new antiviral drug designs targeting kinetic cotranscriptional folding pathways in viral RNAs.
Antisense RNA C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms a triplex-like structure and binds small synthetic ligand
Authors: Błaszczyk Leszek , Ryczek Marcin , Das Bimolendu , Mateja-Pluta Martyna , Bejger Magdalena , Śliwiak Joanna , Nakatani Kazuhiko , Kiliszek Agnieszka
Published: May 2024

The abnormal expansion of GGGGCC/GGCCCC hexanucleotide repeats (HR) in C9orf72 is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Structural polymorphisms of HR result in the multifactorial pathomechanism of ALS/FTD. Consequently, many ongoing studies are focused at developing therapies targeting pathogenic HR RNA. One of them involves small molecules blocking sequestration of important proteins, preventing formation of toxic nuclear foci. However, rational design of potential therapeutics is hindered by limited number of structural studies of RNA-ligand complexes. We determined the crystal structure of antisense HR RNA in complex with ANP77 ligand (1.1 Å resolution) and in the free form (0.92 and 1.5 Å resolution). HR RNA folds into a triplex structure composed of four RNA chains. ANP77 interacted with two neighboring single-stranded cytosines to form pseudo-canonical base pairs by adopting sandwich-like conformation and adjusting the position of its naphthyridine units to the helical twist of the RNA. In the unliganded structure, the cytosines formed a peculiar triplex i-motif, assembled by trans C•C+ pair and a third cytosine located at the Hoogsteen edge of the C•C+ pair. These results extend our knowledge of the structural polymorphisms of HR and can be used for rational design of small molecules targeting disease-related RNAs.
Global economic order and global economic governance
Authors: Susskind Daniel , Vines David
Published: May 2024

This issue of the Oxford Review of Economic Policy explores the origins of the US-led liberal multilateral economic order in the post-war world and the threats which that order now faces, drawing on contributions from two different groups of people—academic international relations (IR) scholars and international economists. This introductory essay attempts to weave the various strands of this intellectual collaboration together. First, it provides a narrative history of how economic collaboration emerged in the aftermath of the Second World War. Second, it describes the nature of the global economic governance that emerged and provides a new formal framework for analysing it, making use of the idea of ‘concerted unilateralism’. Third, it explores how contemporary challenges—a broadening of policy requirements, the rise of economic nationalism, and the rise of China as a new hegemon—mean that the global economic order is now in flux. And finally, it concludes with a general observation that runs through the paper: that IR scholars are inclined to analyse international economic regimes, economists to study particular policy proposals, and that these two perspectives can—and should—complement one another.
Alternative electron pathways of photosynthesis power green algal CO2 capture
Authors: Peltier Gilles , Stoffel Carolyne , Findinier Justin , Madireddi Sai Kiran , Dao Ousmane , Epting Virginie , Morin Amélie , Grossman Arthur , Li-Beisson Yonghua , Burlacot Adrien
Published: May 2024

Microalgae contribute to about half of global net photosynthesis, which converts sunlight into the chemical energy (ATP and NADPH) used to transform CO2 into biomass. Alternative electron pathways of photosynthesis have been proposed to generate additional ATP that is required to sustain CO2 fixation. However, the relative importance of each alternative pathway remains elusive. Here, we dissect and quantify the contribution of cyclic, pseudo-cyclic, and chloroplast-to-mitochondrion electron flows for their ability to sustain net photosynthesis in the microalga Chlamydomonas reinhardtii. We show that (i) each alternative pathway can provide sufficient additional energy to sustain high CO2 fixation rates, (ii) the alternative pathways exhibit cross-compensation, and (iii) the activity of at least one of the three alternative pathways is necessary to sustain photosynthesis. We further show that all pathways have very different efficiencies at energizing CO2 fixation, with the chloroplast–mitochondrion interaction being the most efficient. Overall, our data lay bioenergetic foundations for biotechnological strategies to improve CO2 capture and fixation.
A transthyretin-like protein acts downstream of miR397 and LACCASE to regulate grain yield in rice
Authors: Yu Yang , He Rui-Rui , Yang Lu , Feng Yan-Zhao , Xue Jiao , Liu Qing , Zhou Yan-Fei , Lei Meng-Qi , Zhang Yu-Chan , Lian Jian-Ping , Chen Yue-Qin
Published: May 2024

Increasing grain yield is a major goal of breeders due to the rising global demand for food. We previously reported that the miR397–LACCASE (OsLAC) module regulates brassinosteroid (BR) signaling and grain yield in rice (Oryza sativa). However, the precise roles of laccase enzymes in the BR pathway remain unclear. Here, we report that OsLAC controls grain yield by preventing the turnover of TRANSTHYRETIN-LIKE (OsTTL), a negative regulator of BR signaling. Overexpressing OsTTL decreased BR sensitivity in rice, while loss-of-function of OsTTL led to enhanced BR signaling and increased grain yield. OsLAC directly binds to OsTTL and regulates its phosphorylation-mediated turnover. The phosphorylation site Ser226 of OsTTL is essential for its ubiquitination and degradation. Overexpressing the dephosphorylation-mimic form of OsTTL (OsTTLS226A) resulted in more severe defects than did overexpressing OsTTL. These findings provide insight into the role of an ancient laccase in BR signaling and suggest that the OsLAC–OsTTL module could serve as a target for improving grain yield.
Sensitivity of miRNA-181a, miRNA-23b and miRNA-16 in the Late-Onset Neonatal Sepsis: A Diagnostic Study
Authors: Katta Divya , Sridharan Kopula Satyamoorthy , Balakrishnan Uma Maheswari , Amboiram Prakash , Kumar Kennedy
Published: May 2024

Objective

To evaluate the expression and diagnostic value of levels of the microRNAs (miRNAs), miRNA-181a, miRNA-23b, and miRNA-16, in late-onset neonatal sepsis (LOS) and compare them with the diagnostic utility of C-reactive protein (CRP) levels.

Methods

This was a prospective diagnostic study conducted between January 2021 and March 2023 at a tertiary care center (Sri Ramachandra Hospital) in India. Quantitative real-time polymerase chain reaction was performed to determine miRNA-181a, miRNA-23b, and miRNA-16 expression levels, and CRP was measured by nephelometry. The diagnostic value of miRNA and CRP levels were analyzed using receiver operating characteristic (ROC) curves. ROC curves were utilized to determine optimal cutoff points, and Mann–Whitney tests were performed using SPSS to ascertain P values, with statistical significance defined as <0.05.

Results

This study included 100 samples, with 50 cases of culture-proven LOS (27 females, 23 males) and 50 healthy controls (31 females, 19 males). In LOS, miRNA-181a and miRNA-23b expression levels were significantly downregulated (P < 0.001), with area under the curve (AUC) values of 0.83 and 0.92, respectively, whereas those of miRNA-16 were significantly upregulated (P < 0.001; AUC = 0.97). In comparison, CRP levels had an AUC value of 0.831 (P < 0.001). Further, miRNA-23b showed the highest sensitivity (98%) of markers tested, whereas miRNA-16 exhibited the highest specificity (96%).

Conclusion

MiRNA, especially miRNA-16, shows diagnostic potential for neonatal sepsis compared with traditional biomarkers like CRP and procalcitonin, suggesting its use as an early marker for LOS. However, further cohort studies are needed before practical application.
Patient Satisfaction Using BREAST-Q and Breast Implant Illness after Breast Reconstruction in Transwomen
Authors: McCranie Alec S. , Desjardins Haley E. , Allenby Taylor H. , Mathes David W. , Wong Corrine J.
Published: May 2024

Background:

Gender-affirming breast augmentation comprises an increasing portion of breast augmentations performed by plastic surgeons. Satisfaction and breast implant illness (BII) symptoms in this population have not been well studied. This study aimed to evaluate satisfaction and BII symptoms in transwomen who received nontextured implants as part of their breast reconstruction.

Methods:

We conducted a retrospective review of transwomen who underwent breast augmentation for gender-affirming surgery. We performed telephone survey evaluation using the BREAST-Q questionnaire preoperatively, 6 months and 1 year after breast implant placement. Survey evaluation asking about BII symptoms was also administered at the same time points.

Results:

Twenty-six patients completed the BREAST-Q survey, which demonstrated significantly improved satisfaction postoperatively at 6 and 12 months when compared with median preoperative scores for psychosocial (P < 0.001; P < 0.001), sexual (P < 0.001; P < 0.001), and overall satisfaction with breasts (P < 0.001; P < 0.001). Physical well-being of the chest decreased at 6 months (P < 0.001) but improved in comparison with 12 months (P < 0.001). Thirty-four patients completed the BII survey, with 18% reporting symptoms at 3 months and 29% at 1 year. Zero patients requested explantation.

Conclusions:

Transwomen exhibit a significant increase in breast, psychosocial, and sexual well-being after breast augmentation. However, patients experienced a decreased physical well-being, and many report symptoms associated with BII. These results can be used to better counsel these individuals preoperatively and set reasonable postoperative expectations. Further studies investigating long-term satisfaction in larger cohorts are needed.
Application of 3D Printing in Cleft Lip and Palate Repair
Authors: Kelly Sophie S. , Suarez Camila A. , Mirsky Nicholas A , Slavin Blaire V. , Brochu Baylee , Vivekanand Nayak Vasudev , El Shatanofy Muhammad , Witek Lukasz , Thaller Seth R , Coelho Paulo G.
Published: May 2024

This manuscript reviews the transformative impact of 3-dimensional (3D) printing technologies in the treatment and management of cleft lip and palate (CLP), highlighting its application across presurgical planning, surgical training, implantable scaffolds, and postoperative care. By integrating patient-specific data through computer-aided design and manufacturing, 3D printing offers tailored solutions that improve surgical outcomes, reduce operation times, and enhance patient care. The review synthesizes current research findings, technical advancements, and clinical applications, illustrating the potential of 3D printing to revolutionize CLP treatment. Further, it discusses the future directions of combining 3D printing with other innovative technologies like artificial intelligence, 4D printing, and in situ bioprinting for more comprehensive care strategies. This paper underscores the necessity for multidisciplinary collaboration and further research to overcome existing challenges and fully utilize the capabilities of 3D printing in CLP repair.
Point-of-Care Ultrasonography to Confirm Endotracheal Tube Placement
Authors: Gonzalez Juan M. , Ortega Johis , Gonzalez Juan E. , Crenshaw Nichole , McGhee Stephen , Groom Jeffrey
Published: May 2024

Ensuring correct placement of the endotracheal tube (ETT) during intubation is an important step to avoid complications. Appropriate placement of the ETT can be challenging and, if done incorrectly, can lead to complications such as hypoxemia, atelectasis, hyperinflation, barotrauma, cardiovascular instability, end organ damage, and even death. Although several procedures exist to help assess ETT confirmation, all have limitations, are not always reliable, and vary in their degree of accuracy. Point-of-care ultrasound (POCUS) has emerged as a useful tool in the emergency department for quick diagnosis and treatment of many emergency conditions (Gonzalez et al., 2020). The purpose of this paper is to describe a systematic approach for the emergency nurse practitioner to use POCUS to assess proper endotracheal placement and the positioning within the trachea based on prior studies that compare this modality to traditional ones.
Fast-Track Training in Emergency Department During the COVID-19 Pandemic: Evaluation of a Hybrid Education Model
Authors: Xu Hui (Grace) , Johnston Amy N.B. , Ray-Barruel Gillian
Published: May 2024

Introduction:

Emergency department (ED) fast track (FT) for the ambulatory, minor injury patient cohort requires rapid patient assessment, treatment, and turnover, yet specific nursing education is limited. The study aimed to test the feasibility and staff satisfaction of an education program to expand nursing skills and knowledge of managing FT patients during the COVID-19 pandemic.

Methods:

This quasi-experimental study, including self-rating surveys and interviews, assessed the pre- and postimplementation of an education program for nurses working in FT in a metropolitan hospital ED in Australia. Hybrid (face-to-face and Teams) education sessions on 10 topics of staff-perceived limited knowledge were delivered over 8 months.

Results:

Participants demonstrated higher knowledge scores after the implementation of short online education sessions to cover the core facets of minor injury management. Overall staff satisfaction with the program was high. Interview discussions involved three key themes, including “benefits to staff learning,” “positive impact on patient care and flow,” and “preferred mode of delivery.”

Conclusiions:

Recorded education sessions on minor injury topics for nurses working in FT have proved effective, and this program has now become a core facet of ED education in our hospital.
Ulysses spacecraft
in situ
detections of cometary dust trails
Authors: Krüger Harald , Strub Peter , Grün Eberhard
Published: May 2024

The Ulysses spacecraft was launched in 1990 and, after a Jupiter swing-by in 1992, became the first interplanetary spacecraft orbiting the Sun on a highly inclined trajectory with an inclination of

79

∘

. The spacecraft was equipped with an impact ionization dust detector which provided 17 years of
in situ
dust measurements in interplanetary space from 1990 to 2007. Cometary meteoroid streams (also referred to as trails) exist along the orbits of comets, forming fine structures of the interplanetary dust cloud. We use the Interplanetary Meteoroid Environment for eXploration (IMEX) dust streams in space model (Soja RH
et al
. 2015 Characteristics of the dust trail of 67P/Churyumov-Gerasimenko: an application of the IMEX model.
Astron. Astrophys.
583
, A18. (doi:
10.1051/0004-6361/201526184
)) to predict cometary stream traverses by Ulysses and re-analyse the Ulysses dust dataset in order to identify impacts of cometary stream particles detected during such trail traverses. We identify 19 particles compatible with three Ulysses trail traverses on 12 March 1995, 25–27 April 2001 and 16–19 May 2001. The particle origin is compatible with up to five comets, i.e. 10P/Tempel 2, 146P/Shoemaker-LINEAR, 267P/LONEOS and possibly 45P/Honda-Mrkos-Pajdušáková and P/1999 RO28 (LONEOS). We find a dust spatial density in these trails of approximately

2
−
7
⋅

10

−
8

m

−
3

. The radii of the detected cometary stream particles derived from the dust instrument calibration are in the micrometre range. The
in situ
analysis of meteoroid trail particles in space, which can be traced back to their source bodies, opens a new opportunity for remote compositional analysis of comets and asteroids without the necessity to send a spacecraft to or even land on these celestial bodies, opening new opportunities for future space missions equipped with
in situ
dust analyzers.

This article is part of the theme issue 'Dust in the Solar System and beyond'.
Sarcina Ventriculi in Association with Gastric Ulcer: A Case Report
Authors: Simkhada Ankita , Acharya Pritha , Shrivastav Shreya
Published: May 2024

Sarcina ventriculi is a gram positive bacteria which has been reported in patients with delayed gastric emptying as well as in association with cases of gastric ulcer and gastric carcinoma. Although it has been reported frequently in veterinary cases as a cause of fatal diseases, exact pathogenesis in humans is yet to be identified. We report here, a case of an elderly male who presented with hematemesis following which an upper gastrointestinal endoscopy was done and a gastric ulcer was revealed. Histopathological examination revealed Sarcina ventriculi in association with ulcer.
Increased tolerance to commonly used antibiotics in a Pseudomonas aeruginosa ex vivo porcine keratitis model
Authors: Okurowska Katarzyna , Monk Peter N. , Karunakaran Esther
Published: May 2024

Introduction. Bacterial keratitis, particularly caused by Pseudomonas aeruginosa, is challenging to treat because of multi-drug tolerance, often associated with the formation of biofilms. Antibiotics in development are typically evaluated against planktonic bacteria in a culture medium, which may not accurately represent the complexity of infections in vivo.

Hypothesis/Gap Statement. Developing a reliable, economic ex vivo keratitis model that replicates some complexity of tissue infections could facilitate a deeper understanding of antibiotic efficacy, thus aiding in the optimization of treatment strategies for bacterial keratitis.

Methodology. Here we investigated the efficacy of three commonly used antibiotics (gentamicin, ciprofloxacin and meropenem) against Pseudomonas aeruginosa cytotoxic strain PA14 and invasive strain PA01 using an ex vivo porcine keratitis model.

Results. Both strains of P. aeruginosa were susceptible to the MIC of the three tested antibiotics. However, significantly higher concentrations were necessary to inhibit bacterial growth in the minimum biofilm eradication concentration (MBEC) assay, with both strains tolerating concentrations greater than 512 mg l−1 of meropenem. When MIC and higher concentrations than MBEC (1024 mg l−1) of antibiotics were applied, ciprofloxacin exhibited the highest potency against both P. aeruginosa strains, followed by meropenem, while gentamicin showed the least potency. Despite this, none of the antibiotic concentrations used effectively cleared the infection, even after 18 h of continuous exposure.

Conclusions. Further exploration of antibiotic concentrations and aligning dosing with clinical studies to validate the model is needed. Nonetheless, our ex vivo porcine keratitis model could be a valuable tool for assessing antibiotic efficacy.
Combined effect of SAR-endolysin LysKpV475 with polymyxin B and Salmonella bacteriophage phSE-5
Authors: Gontijo Marco , Pereira Teles Mateus , Martins Correia Hugo , Pérez Jorge Genesy , Rodrigues Santos Goes Isabella Carolina , Fasabi Flores Anthony Jhoao , Braz Márcia , de Moraes Ceseti Lucas , Zonzini Ramos Priscila , Rosa e Silva Ivan , Pereira Vidigal Pedro Marcus , Kobarg Jörg , Miguez Couñago Rafael , Alvarez-Martinez Cristina Elisa , Pereira Carla , Freire Carmen S. R. , Almeida Adelaide , Brocchi Marcelo
Published: May 2024

Endolysins are bacteriophage (or phage)-encoded enzymes that catalyse the peptidoglycan breakdown in the bacterial cell wall. The exogenous action of recombinant phage endolysins against Gram-positive organisms has been extensively studied. However, the outer membrane acts as a physical barrier when considering the use of recombinant endolysins to combat Gram-negative bacteria. This study aimed to evaluate the antimicrobial activity of the SAR-endolysin LysKpV475 against Gram-negative bacteria as single or combined therapies, using an outer membrane permeabilizer (polymyxin B) and a phage, free or immobilized in a pullulan matrix. In the first step, the endolysin LysKpV475 in solution, alone and combined with polymyxin B, was tested in vitro and in vivo against ten Gram-negative bacteria, including highly virulent strains and multidrug-resistant isolates. In the second step, the lyophilized LysKpV475 endolysin was combined with the phage phSE-5 and investigated, free or immobilized in a pullulan matrix, against Salmonella enterica subsp. enterica serovar Typhimurium ATCC 13311. The bacteriostatic action of purified LysKpV475 varied between 8.125 μg ml−1 against Pseudomonas aeruginosa ATCC 27853, 16.25 μg ml−1 against S. enterica Typhimurium ATCC 13311, and 32.50 μg ml−1 against Klebsiella pneumoniae ATCC BAA-2146 and Enterobacter cloacae P2224. LysKpV475 showed bactericidal activity only for P. aeruginosa ATCC 27853 (32.50 μg ml−1) and P. aeruginosa P2307 (65.00 μg ml−1) at the tested concentrations. The effect of the LysKpV475 combined with polymyxin B increased against K. pneumoniae ATCC BAA-2146 [fractional inhibitory concentration index (FICI) 0.34; a value lower than 1.0 indicates an additive/combined effect] and S. enterica Typhimurium ATCC 13311 (FICI 0.93). A synergistic effect against S. enterica Typhimurium was also observed when the lyophilized LysKpV475 at ⅔ MIC was combined with the phage phSE-5 (m.o.i. of 100). The lyophilized LysKpV475 immobilized in a pullulan matrix maintained a significant Salmonella reduction of 2 logs after 6 h of treatment. These results demonstrate the potential of SAR-endolysins, alone or in combination with other treatments, in the free form or immobilized in solid matrices, which paves the way for their application in different areas, such as in biocontrol at the food processing stage, biosanitation of food contact surfaces and biopreservation of processed food in active food packing.
Critical risk management strategies for the operation of public–private partnerships: a vulnerability perspective of infrastructure projects
Authors: Jiang Weiling , Jiang Jie , Martek Igor , Jiang Wen
Published: May 2024

Purpose

The success of public–private partnership (PPP) projects is highly correlated to the successful management of risks encountered during the operation phase. PPP projects are especially exposed to risk due to the long operation period over which revenues need to be generated to recoup substantial initial investment and operational running costs. Despite the critical impact of risk exposure, limited research has been specifically undertaken on the matter of operational risk management. This study seeks to address this oversight by identifying and evaluating operational risk management strategies for PPPs.

Design/methodology/approach

Vulnerability theory is the theoretical lens used, with context drawn from Chinese PPP projects. Based on the data collected from expert interviews and questionnaires, 28 operational risk management strategies are identified. A fuzzy synthetic method is employed to analyze the effectiveness of the 28 strategies.

Findings

The findings reveal that providing an exit mechanism clause into the contract, establishing a comprehensive performance evaluation mechanism and developing a clear compensation mechanism are the top three effective strategies. This study also reveals that risk mitigation approaches that reduce vulnerability prove more effective than attempts to reduce external threats. Specifically, strategies aimed at managing contract, political, technical and financial risk are the most effective.

Originality/value

The findings of this study extend current knowledge regarding the risk management of PPP projects. They also offer a reference by which practitioners may select effective operational risk management pathways and thereby, galvanize the sustainable development of PPPs.
The roots of legitimacy in ethnic-cultural festivals and their influence on residents’ loyalty: an analysis of two Brazilian Oktoberfests
Authors: Fiuza Thamires Foletto , Zucco Fabricia Durieux , Añaña Edar da Silva
Published: May 2024

Purpose

Legitimacy is a classic theme, quite present in organisational studies in general, but in the field of tourism it still has room to advance. For that reason, this research seeks to delimit the concept of legitimacy and adapt it to the context of tourism events; and seeks to validate a measurement instrument that allows to evaluate of its recognition in the imagination of residents, and to evaluate the impacts of this construct on residents’ trust in the organisers of Brazilian Oktoberfest, on the negative externalities of those events and, ultimately, on the achievement of residents’ loyalty.

Design/methodology/approach

The locus of the research are the cities of Blumenau, Santa Catarina and Santa Cruz do Sul, Santa Catarina, both located in southern Brazil, whose residents answered an online questionnaire about the legitimacy of the Oktoberfest held there. A total of 365 valid questionnaires were collected, tabulated in statistical software and interpreted using exploratory-confirmatory factor analysis and structural equation modelling.

Findings

The results show that festival legitimacy is a theoretical construct that can be measured as either a first-order or second-order factor, consisting of three factors, called moral legitimacy, pragmatic legitimacy and cognitive legitimacy.

Originality/value

This research provides a valid and reliable tool for assessing local residents' acceptance of ethno-cultural festivals. It also shows variations in the perception of legitimacy, demonstrating that this can influence other aspects of residents' perception of ethnocultural events.
Urban green open space in developing countries: Indonesia regulations, problems and alternative solutions
Authors: Priyanta Maret , Zulkarnain Cut Sabina Anasya
Published: May 2024

Purpose

This paper aims to work toward a new approach in providing green open spaces in the middle of urban land in Indonesia that has been densely built up and on it has attached land rights. An approach is needed through a specific spatial policy that contains zoning regulations for the provision of public green open spaces on top of residential houses built on the green zoning plans.

Design/methodology/approach

This approach considers an interconnected ecological holistic approach, as previously existing regulations have not normatively identified the green open space as an ecological landscape consisting of blue open spaces and several objects that function as green open spaces.

Findings

Indonesia in terms of green open space for local climate instrument is still identified as one of the three lowest countries in Southeast Asia in the number of green open space areas. We found that the regulating process of development rights and property rights, in the construction of Indonesian law, still requires many alternative efforts to this day in providing urban green open spaces. The delivery of desired outcomes depends on the alternative policy as a form of legal politics in compensating planning and community interests through developing green open spaces in an ecoregion approach.

Originality/value

This writing was shaped by the understandings of the author with regards to the development of urban green open space regulating issues in Indonesia as one of the emerging country group in Asia and Jakarta as the second-most populous urban area in the world. This paper aims to work toward providing green urban open spaces in Indonesia that has been densely built up and on it has attached land rights, through a specific spatial policy that contains zoning regulations for the provision of public green open spaces on top of residential houses built on the green zoning plans.
@Brand-to-@brand: the value co-creating impact of social media interactions on consumer–brand evaluations
Authors: Ross Spencer M.
Published: May 2024

Purpose

Conspicuously absent from the branding literature is research on the brand-to-brand (Br2Br) interface enabled by social media. The author proposes how networked brands-as-actors integrate their resources as Br2Br interactions that co-create consumer–brand value. As a secondary contribution, the author provides an empirical baseline exploration of the value co-creating impact of Br2Br interactions on consumer–brand evaluations and social media engagement.

Design/methodology/approach

Three streams of research aid in conceptualizing the value co-creating process of Br2Br interactions. A follow-up exploratory study uses a controlled Br2Br interaction stimulus in a 2 × 2 × 2 between-subjects design, where brand familiarity and product category complementarity are manipulated, and interaction spillover effects are analyzed using structural equation modeling.

Findings

The author finds Br2Br interactions positively affect consumer–brand evaluations and social media engagement likelihood. Spillover effects of these interactions are symmetric for consumer–brand evaluations for both brands. However, brand familiarity moderates the effects of Br2Br interactions on consumer–brand evaluations.

Originality

The author lays the groundwork for future research on the complexities of Br2Br interactions – including brand personality conflict, interaction duration and paratextual language – and the boundary conditions for Br2Br and brand-to-consumer relationships.
Accounting as a social and moral practice: bridging cultures, balancing Indigenous factors, and fostering social accountability
Authors: Narayan Anil K. , Oru Marianne
Published: May 2024

Purpose

This study aims to investigate accounting practices within a non-Western (Indigenous) context and provide insights into alternative accounting approaches and perspectives.

Design/methodology/approach

This study adopts an interpretive research approach to gain an in-depth insight into the functioning of accounting in Solomon Islands’ unique cultural and social-political context. In-depth interviews were conducted to gain insights into the perceptions and meanings held by participants concerning Western accounting practices and their limitations.

Findings

The findings provide unique insights into different interpretations of accounting and accountability through two distinct cultural lenses – Western and non-Western. The complementary and rival explanations on what accounting and accountability are doing and what accounting and accountability should be doing will help close the gap in knowledge and contribute to shaping a better world for Indigenous people.

Practical implications

Implications for practice involve fostering collaborative efforts among individuals, communities, leaders and institutions to harness cultural strengths through accounting. Additionally, continuous capacity building and education are essential to develop accounting skills, enhance financial literacy, promote professional expertise and build a pool of skilled accountants with local knowledge to support Indigenous communities.

Originality/value

This study is original and provides novel insights supporting the need for accounting to recognise the importance of Indigenous perspectives, adapt to cultural sensitivity and integrate cultural norms and values into accounting practices to make an impact and achieve greater social and moral accountability.
From crisis to opportunity through innovation
Authors: Montes Jose , Gómez-Cruz Nelson Alfonso , Batz Aglaya , Serrano Cárdenas Lizeth Fernanda , Mora Holguín Henry
Published: May 2024

Purpose

This study aims to explore the strategic decisions at innovation level implemented by firms to thrive and transform themselves during crises. This study also aims to provide insights to answer the question: Why do some firms decide to implement certain types of innovation during a crisis?

Design/methodology/approach

This research was carried out through a multiple case study involving 22 firms. The methods were implemented in three steps to increase rigor and the replication of the study: identification and selection of cases, data collection through interviews triangulated with online information and analysis based on aggregating themes and finding patterns.

Findings

In the face of the COVID-19 pandemic, the companies analyzed focused their activities mainly on developing new features or functionalities for their products or services. Most of the firms implemented innovations across nearly all ten categories outlined by Keeley et al. (2013). Many of the implemented innovations involved personalized and superior service enhancements, process efficiency optimizations, channel diversification initiatives and new ways to collaborate to generate value. In general, the main drivers that led firms to decide to implement these innovations include reducing costs, enhancing operational efficiency, generating new revenue streams, augmenting sales and enhancing client relationships.

Practical implications

This research significantly advances the convergence of innovation, strategy and crisis in three impactful ways. First, it constructs a pragmatic and evidence-based framework, consolidating the primary catalysts, innovation categories and strategies adopted by firms in response to the challenges posed by the COVID-19 crisis. Second, it offers insights for guiding decision-making processes related to innovation, presenting actionable recommendations derived from the study’s findings. Thirdly, this study highlights critical perspectives that can guide governmental intervention, facilitating the formulation of more tailored and effective policies to assist companies during crisis periods.

Originality/value

This study centers on developing countries, specifically examining Colombian firms, considering their unique characteristics and priorities. Surprisingly, there is a scarcity of studies delving into the innovation and transformation of firms during the COVID-19 crisis in nations sharing cultural, economic and political similarities with Colombia.
Inducing employee performance among state-owned enterprises, through employee ethical behaviour and ethical leadership
Authors: Dogbe Courage Simon Kofi , Ablornyi Kennedy Kofi , Pomegbe Wisdom Wise Kwabla , Duah Evans
Published: May 2024

Purpose

This study aims to examine how ethical leadership enhances the relationship between employee ethical behaviour and the job performance of employees in state-owned enterprises (SOEs).

Design/methodology/approach

This study was a survey, with data collected using a structured questionnaire. The study focused on employees from SOEs in Ghana. The sample covers 238 employees drawn from 10 SOEs. Data was analyzed using structural equation modelling.

Findings

The study concludes that employee ethical behaviour positively influenced the job performance of employees of SOEs in Ghana. The effect of ethical leadership on employee job performance was positively significant. Finally, ethical leadership positively moderated the effect of employee ethical behaviour on the job performance of employees of SOEs.

Research limitations/implications

Future research should look at identifying the specific behaviours of ethical employees that influence improved job performance. Also, future research could conduct a comparative study of private-owned enterprises and SOEs.

Practical implications

Attention should also be paid to ethical leadership, as it strongly enhanced both employee job performance and the quality of employee ethical behaviour required for increased job performance of employees.

Originality/value

Extant studies have paid limited attention to understanding how the interaction between employee ethical behaviour and ethical leadership will enhance employee job performance.
Can vermicomposting be used to process hyperaccumulator biomass in nickel agromining?
Authors: Quintela‐Sabarís Celestino , Fernández Dosouto Adrián , Gómez‐Brandón María , Domínguez Jorge
Published: May 2024

Hyperaccumulator plants are a botanical curiosity that have allowed the development of agromining of metals, with a special focus on nickel. In nickel agromining, this element is recovered from ashed hyperaccumulators cultivated on metal‐rich soils. In order to explore bio‐based approaches for the decomposition of hyperaccumulator biomass and nickel recovery that do not include burning, we performed a vermicomposting experiment using the earthworm species Eisenia andrei and the biomass of Bornmuellera emarginata (which contained almost 1% of nickel). We conducted our experiment for 12 weeks and assessed the decomposition process of the hyperaccumulator biomass, changes in earthworm number and biomass, and changes in nickel concentration and mobility. Despite the initial mortality and an increase of Ni concentration in earthworm tissues, E. andrei was able to decompose B. emarginata biomass. This process also showed a massive colonization of the biomass by a fungus during the first weeks of the assay. Our results indicate that the vermicomposted hyperaccumulator biomass had a higher nickel concentration than the starting material but the diethylenetriaminepentaacetic acid‐extractable nickel decreased. At the same time, due to earthworm activity, the nickel was redistributed and diluted in the vermicompost bedding, reducing the interest of this approach for agromining, but opening the perspective of using the vermicomposted hyperaccumulator biomass as an organic amendment in nickel‐deficient crops.
Party competition on social media: Evidence from politicians' tweets
Authors: Eriksen Daniel Møller
Published: May 2024

A blooming research agenda has begun examining the influence of party competition dynamics on politician social media behaviour. Most studies focus on the US context, generally finding little evidence that party competition dynamics influence which policy issues politicians attend to on these platforms. Instead, I turn to the Danish context and show how party competition dynamics exert a substantial influence on politicians' attention to issues in their tweets. First, I map the level of politician issue attention on Twitter across several years outside election campaigns. Second, I show that party issue ownership and the status of a party as a government or opposition party strongly influence politicians' attention to issues on the platform. Third, I provide novel insights into how the interplay between party issue ownership and internal party organisation influences politician issue attention on Twitter. The findings indicate that the tweets posted by politicians are an integral aspect of contemporary party competition.
Changing US Support for Public Health Data Use Through Pandemic and Political Turmoil
Authors: SCHMIT CASON D. , LARSON BRIAN N. , TANABE THOMAS , RAMEZANI MAHIN , ZHENG QI , KUM HYE‐CHUNG
Published: May 2024

Policy Points

This study examines the impact of several world‐changing events in 2020, such as the pandemic and widespread racism protests, on the US population's comfort with the use of identifiable data for public health. Before the 2020 election, there was no significant difference between Democrats and Republicans. However, African Americans exhibited a decrease in comfort that was different from other subgroups.

Our findings suggest that the public remained supportive of public health data activities through the pandemic and the turmoil of 2020 election cycle relative to other data use. However, support among African Americans for public health data use experienced a unique decline compared to other demographic groups.

Context

Recent legislative privacy efforts have not included special provisions for public health data use. Although past studies documented support for public health data use, several global events in 2020 have raised awareness and concern about privacy and data use. This study aims to understand whether the events of 2020 affected US privacy preferences on secondary uses of identifiable data, focusing on public health and research uses.

Methods

We deployed two online surveys—in February and November 2020—on data privacy attitudes and preferences using a choice‐based–conjoint analysis. Participants received different data‐use scenario pairs—varied by the type of data, user, and purpose—and selected scenarios based on their comfort. A hierarchical Bayes regression model simulated population preferences.

Findings

There were 1,373 responses. There was no statistically significant difference in the population's data preferences between February and November, each showing the highest comfort with population health and research data activities and the lowest with profit‐driven activities. Most subgroups’ data preferences were comparable with the population's preferences, except African Americans who showed significant decreases in comfort with population health and research.

Conclusions

Despite world‐changing events, including a pandemic, we found bipartisan public support for using identifiable data for public health and research. The decreasing support among African Americans could relate to the increased awareness of systemic racism, its harms, and persistent disparities. The US population's preferences support including legal provisions that permit public health and research data use in US laws, which are currently lacking specific public health use permissions.
Regulating Laboratory Tests: What Framework Would Best Support Safety and Validity?
Authors: HORROW CAROLINE , KESSELHEIM AARON S.
Published: May 2024

Policy Points

With increasing public attention to cases of inaccurate and misleading laboratory‐developed tests, there have been calls for regulatory reform.

To protect patients from faulty laboratory tests, we need a framework that balances comprehensive test review with laboratory flexibility.

The Verifying Accurate Leading‐edge IVCT [In Vitro Clinical Test] Development (VALID) Act would have helped ensure laboratory test safety and validity through a much‐needed expansion of Food and Drug Administration (FDA) oversight. However, Congress did not pass the VALID Act in 2022, forcing the FDA to start the regulatory reform process on its own.
Housing prices, costs, and policy: The housing supply equation in Ireland since 1970
Authors: Günnewig‐Mönert Maximilian , Lyons Ronan C.
Published: May 2024

This article examines the responsiveness of new housing supply to prices and costs, using the case of Ireland at quarterly frequency from the 1970s, as well as a county‐level panel from the 1990s. Across four error‐correction specifications, and supported by an instrumental variables approach, we find the estimated elasticity of new housing supply to prices of +0.9 in the baseline, while that of costs is larger in magnitude (−1.9). We present evidence that responsiveness to prices rose after the 1980s, then fell in the 2000s, before rising again and also that elasticities vary at the county level.
Risk factors and outcomes for refeeding syndrome in acute ischaemic stroke patients
Authors: Chen Shumin , Cai Dongchun , Lai Yuzheng , Zhang Yongfang , He Jianfeng , Zhou Liang , Sun Hao
Published: May 2024

Aim

Patients with acute ischaemic stroke are more likely to develop refeeding syndrome due to increased need for nutritional support when suffering alterations of consciousness and impairment of swallowing. This study aimed to evaluate the incidence, risk factors and outcomes of refeeding syndrome in stroke patients.

Methods

This was a retrospective observational study, using the prospective stroke database from hospital, included all consecutive acute ischaemic stroke patients who received enteral nutrition for more than 72 h from 1 January 2020 and 31 December 2022. Refeeding syndrome was defined as occurrence of new‐onset hypophosphataemia within 72 h after enteral feeding. Multiple logistic regression analysis was conducted to evaluate risk factors and relationships between refeeding syndrome and stroke outcomes.

Results

338 patients were included in the study. 50 patients (14.8%) developed refeeding syndrome. Higher scores on National Institutes of Health Stroke Scale and Nutritional Risk Screening 2002, albumin <30 g/L and BMI <18.5 kg/m2 were risk factors for refeeding syndrome. Moreover, refeeding syndrome was independently associated with a 3‐month modified Rankin Scale score of >2 and 6‐month mortality.

Conclusions

Refeeding syndrome was common in stroke patients and higher baseline National Institutes of Health Stroke Scale, higher Nutritional Risk Screening 2002, albumin <30 g/L and BMI <18.5 kg/m2 were independent risk factors of refeeding syndrome. Occurrence of refeeding syndrome was significantly associated with higher 3‐month modified Rankin Scale and 6‐month mortality.
Incident psychotic experiences following self‐reported use of high‐potency cannabis: Results from a longitudinal cohort study
Authors: Hines Lindsey A. , Heron Jon , Zammit Stanley
Published: May 2024

Background and aims

High‐potency cannabis has been associated with increased risk of psychosis, but a lack of prospective data hinders understanding of causality in this relationship. This study aimed to combine prospective report of cannabis use with retrospective report of potency to infer the potency of cannabis used in adolescence and explore whether use of cannabis, and the use of high‐potency cannabis, in adolescence is associated with incident psychotic experiences.

Design

Population‐based birth cohort study.

Setting

United Kingdom.

Participants

n = 5570 participants who reported on any cannabis use (yes/no) age 16 and 18 years, and n = 1560 participants from this group who also retrospectively reported on cannabis potency.

Measurements

In questionnaires at ages 16 and 18, individuals self‐reported lifetime cannabis use, and at age 24, participants reported the type of cannabis they most commonly used in the whole time since first using cannabis. Psychotic experiences were assessed at age 24 years using the semi‐structured Psychosis‐Like Symptom Interview, with incident defined as new‐onset occurring between ages 19 and 24 years.

Findings

Use of high‐potency cannabis at age 16 or 18 was associated with twice the likelihood of experiencing incident psychotic experiences from age 19–24 (Odds Ratio 2.15, 95% Confidence Intervals 1.13–4.06). There was less evidence for an effect of any cannabis use on incident psychotic experiences (Odds Ratio 1.45, 95% Confidence Intervals 0.94–2.12).

Conclusions

Use of high‐potency cannabis appears to be associated with increased likelihood of psychotic experiences.