bluuebunny/crossref_metadata_2025 huggingface dataset:
Single-pixel imaging of a translational object
Authors: Li Shijian , Cai Yan , Wang Yeliang , Yao Xu-ri , Zhao Qing
Published: January 2023

Image-free tracking methods based on single-pixel detectors (SPDs) can track a moving object at a very high frame rate, but they rarely can achieve simultaneous imaging of such an object. In this study, we propose a method for simultaneously obtaining the relative displacements and images of a translational object. Four binary Fourier patterns and two differential Hadamard patterns are used to modulate one frame of the object and then modulated light signals are obtained by SPD. The relative displacements and image of the moving object can be gradually obtained along with the detection. The proposed method does not require any prior knowledge of the object and its motion. The method has been verified by simulations and experiments, achieving a frame rate of 3332 Hz to acquire relative displacements of a translational object at a spatial resolution of 128 × 128 pixels using a 20000-Hz digital micro-mirror device. This proposed method can broaden the application of image-free tracking methods and obtain spatial information about moving objects.
Dynamics of frequency detuning in a hybrid Er-doped mode-locked fiber laser
Authors: Lv Chenyue , Lu Baole , Bai Jintao
Published: January 2023

Frequency detuning of mode-locked fiber lasers displays many remarkable nonlinear dynamical behaviors. Here we report for the first time the evolution of pulses from mode-locking through period pulsation to

Q

-switched mode-locking for three fundamental cases. Our experiments are performed in a hybrid actively and passively amplitude-modulated all-fiber polarization-maintaining mode-locked fiber laser, where the amplitude modulation frequency artificially deviates from the fundamental frequency of the cavity. We design and numerically simulate the laser with coupled Ginzburg–Landau equations. The experimentally observed dynamics of the mode detuning process is discussed with the assistance of the fitted model and numerical simulations, showing the generalizability of the optical mode detuning variation process. Our work provides fundamental insights for understanding perturbations in nonlinear optical resonant cavities and expands the ideas for studying chaotic path theory in hybrid mode-locked fiber lasers.
Skilled motor control of an inverted pendulum implies low entropy of states but high entropy of actions
Authors: Catenacci Volpi Nicola , Greaves Martin , Trendafilov Dari , Salge Christoph , Pezzulo Giovanni , Polani Daniel
Published: January 2023

The mastery of skills, such as balancing an inverted pendulum, implies a very accurate control of movements to achieve the task goals. Traditional accounts of skilled action control that focus on either routinization or perceptual control make opposite predictions about the ways we achieve mastery. The notion of routinization emphasizes the decrease of the variance of our actions, whereas the notion of perceptual control emphasizes the decrease of the variance of the states we visit, but not of the actions we execute. Here, we studied how participants managed control tasks of varying levels of difficulty, which consisted of controlling inverted pendulums of different lengths. We used information-theoretic measures to compare the predictions of alternative accounts that focus on routinization and perceptual control, respectively. Our results indicate that the successful performance of the control task strongly correlates with the decrease of state variability and the increase of action variability. As postulated by perceptual control theory, the mastery of skilled pendulum control consists in achieving stable control of goals by flexible means.
Over-optimism in unsupervised microbiome analysis: Insights from network learning and clustering
Authors: Ullmann Theresa , Peschel Stefanie , Finger Philipp , Müller Christian L. , Boulesteix Anne-Laure
Published: January 2023

In recent years, unsupervised analysis of microbiome data, such as microbial network analysis and clustering, has increased in popularity. Many new statistical and computational methods have been proposed for these tasks. This multiplicity of analysis strategies poses a challenge for researchers, who are often unsure which method(s) to use and might be tempted to try different methods on their dataset to look for the “best” ones. However, if only the best results are selectively reported, this may cause over-optimism: the “best” method is overly fitted to the specific dataset, and the results might be non-replicable on validation data. Such effects will ultimately hinder research progress. Yet so far, these topics have been given little attention in the context of unsupervised microbiome analysis. In our illustrative study, we aim to quantify over-optimism effects in this context. We model the approach of a hypothetical microbiome researcher who undertakes four unsupervised research tasks: clustering of bacterial genera, hub detection in microbial networks, differential microbial network analysis, and clustering of samples. While these tasks are unsupervised, the researcher might still have certain expectations as to what constitutes interesting results. We translate these expectations into concrete evaluation criteria that the hypothetical researcher might want to optimize. We then randomly split an exemplary dataset from the American Gut Project into discovery and validation sets multiple times. For each research task, multiple method combinations (e.g., methods for data normalization, network generation, and/or clustering) are tried on the discovery data, and the combination that yields the best result according to the evaluation criterion is chosen. While the hypothetical researcher might only report this result, we also apply the “best” method combination to the validation dataset. The results are then compared between discovery and validation data. In all four research tasks, there are notable over-optimism effects; the results on the validation data set are worse compared to the discovery data, averaged over multiple random splits into discovery/validation data. Our study thus highlights the importance of validation and replication in microbiome analysis to obtain reliable results and demonstrates that the issue of over-optimism goes beyond the context of statistical testing and fishing for significance.
Humans account for cognitive costs when finding shortcuts: An information-theoretic analysis of navigation
Authors: Lancia Gian Luca , Eluchans Mattia , D’Alessandro Marco , Spiers Hugo J. , Pezzulo Giovanni
Published: January 2023

When faced with navigating back somewhere we have been before we might either retrace our steps or seek a shorter path. Both choices have costs. Here, we ask whether it is possible to characterize formally the choice of navigational plans as a bounded rational process that trades off the quality of the plan (e.g., its length) and the cognitive cost required to find and implement it. We analyze the navigation strategies of two groups of people that are firstly trained to follow a "default policy" taking a route in a virtual maze and then asked to navigate to various known goal destinations, either in the way they want ("Go To Goal") or by taking novel shortcuts ("Take Shortcut"). We address these wayfinding problems using InfoRL: an information-theoretic approach that formalizes the cognitive cost of devising a navigational plan, as the informational cost to deviate from a well-learned route (the "default policy"). In InfoRL, optimality refers to finding the best trade-off between route length and the amount of control information required to find it. We report five main findings. First, the navigational strategies automatically identified by InfoRL correspond closely to different routes (optimal or suboptimal) in the virtual reality map, which were annotated by hand in previous research. Second, people deliberate more in places where the value of investing cognitive resources (i.e., relevant goal information) is greater. Third, compared to the group of people who receive the "Go To Goal" instruction, those who receive the "Take Shortcut" instruction find shorter but less optimal solutions, reflecting the intrinsic difficulty of finding optimal shortcuts. Fourth, those who receive the "Go To Goal" instruction modulate flexibly their cognitive resources, depending on the benefits of finding the shortcut. Finally, we found a surprising amount of variability in the choice of navigational strategies and resource investment across participants. Taken together, these results illustrate the benefits of using InfoRL to address navigational planning problems from a bounded rational perspective.
Expression of virulence and antimicrobial related proteins in Burkholderia mallei and Burkholderia pseudomallei
Authors: Paauw Armand , Scholz Holger C. , Mars-Groenendijk Roos H. , Dekker Lennard J. M. , Luider Theo M. , van Leeuwen Hans C.
Published: January 2023

Background

Burkholderia mallei and Burkholderia pseudomallei are both potential biological threat agents. Melioidosis caused by B. pseudomallei is endemic in Southeast Asia and Northern Australia, while glanders caused by B. mallei infections are rare. Here we studied the proteomes of different B. mallei and B. pseudomallei isolates to determine species specific characteristics.

Methods

The expressed proteins of 5 B. mallei and 6 B. pseudomallei strains were characterized using liquid chromatography high-resolution tandem mass spectrometry (LC-HRMS/MS). Subsequently, expression of potential resistance and virulence related characteristics were analyzed and compared.

Results

Proteome analysis can be used for the identification of B. mallei and B. pseudomallei. Both species were identified based on >60 discriminative peptides. Expression of proteins potentially involved in antimicrobial resistance, AmrAB–OprA, BpeAB–OprB, BpeEF–OprC, PenA as well as several other efflux pump related proteins and putative β-lactamases was demonstrated. Despite, the fact that efflux pump BpeAB–OprB was expressed in all isolates, no clear correlation with an antimicrobial phenotype and the efflux-pump could be established. Also consistent with the phenotypes, no amino acid mutations in PenA known to result in β-lactam resistance could be identified.

In all studied isolates, the expression of virulence (related) factors Capsule-1 and T2SS was demonstrated. The expression of T6SS-1 was demonstrated in all 6 B. pseudomallei isolates and in 2 of the 5 B. mallei isolates. In all, except one B. pseudomallei isolate, poly-beta-1,6 N-acetyl-D-glucosamine export porin (Pga), important for biofilm formation, was detected, which were absent in the proteomes of B. mallei.

Siderophores, iron binding proteins, malleobactin and malleilactone are possibly expressed in both species under standard laboratory growth conditions. Expression of multiple proteins from both the malleobactin and malleilactone polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) clusters was demonstrated in both species. All B. pseudomallei expressed at least seven of the nine proteins of the bactobolin synthase cluster (bactobolin, is a ribosome targeting antibiotic), while only in one B. mallei isolate expression of two proteins of this synthase cluster was identified.

Conclusions

Analyzing the expressed proteomes revealed differences between B. mallei and B. pseudomallei but also between isolates from the same species. Proteome analysis can be used not only to identify B. mallei and B. pseudomallei but also to characterize the presence of important factors that putatively contribute to the pathogenesis of B. mallei and B. pseudomallei.
Bioinformatics and In silico approaches to identify novel biomarkers and key pathways for cancers that are linked to the progression of female infertility: A comprehensive approach for drug discovery
Authors: Hossain Md. Arju , Sohel Md , Rahman Md Habibur , Hasan Md Imran , Khan Md. Sharif , Amin Md. Al , Islam Md. Zahidul , Peng Silong
Published: January 2023

Despite modern treatment, infertility remains one of the most common gynecologic diseases causing severe health effects worldwide. The clinical and epidemiological data have shown that several cancerous risk factors are strongly linked to Female Infertility (FI) development, but the exact causes remain unknown. Understanding how these risk factors affect FI-affected cell pathways might pave the door for the discovery of critical signaling pathways and hub proteins that may be targeted for therapeutic intervention. To deal with this, we have used a bioinformatics pipeline to build a transcriptome study of FI with four carcinogenic risk factors: Endometrial Cancer (EC), Ovarian Cancer (OC), Cervical Cancer (CC), and Thyroid Cancer (TC). We identified FI sharing 97, 211, 87 and 33 differentially expressed genes (DEGs) with EC, OC, CC, and TC, respectively. We have built gene-disease association networks from the identified genes based on the multilayer network and neighbour-based benchmarking. Identified TNF signalling pathways, ovarian infertility genes, cholesterol metabolic process, and cellular response to cytokine stimulus were significant molecular and GO pathways, both of which improved our understanding the fundamental molecular mechanisms of cancers associated with FI progression. For therapeutic intervention, we have targeted the two most significant hub proteins VEGFA and PIK3R1, out of ten proteins based on Maximal Clique Centrality (MCC) value of cytoscape and literature analysis for molecular docking with 27 phytoestrogenic compounds. Among them, sesamin, galangin and coumestrol showed the highest binding affinity for VEGFA and PIK3R1 proteins together with favourable ADMET properties. We recommended that our identified pathway, hub proteins and phytocompounds may be served as new targets and therapeutic interventions for accurate diagnosis and treatment of multiple diseases.
Solitary wave behavior of (2+1)-dimensional Chaffee-Infante equation
Authors: Arshed Saima , Akram Ghazala , Sadaf Maasoomah , Qurrat-ul-ain  , Bilal Riaz Muhammad , Wojciechowski Adam
Published: January 2023

The behavior of gas diffusion in a homogeneous medium is described by the (2+1)-dimensional Chaffee-Infante equation. In this work, the solitary wave behavior of the (2+1)-dimensional Chaffee-Infante equation is studied with the help of extended sinh-Gordon equation expansion technique. Bright, dark, periodic, kink, anti-kink and singular traveling wave patterns are observed for suitable choice of parameters. The 3D graphs, 2D plots and contour plots are included to understand the dynamics of the obtained solutions. The obtained results depict that the extended sinh-Gordon equation expansion technique provides an efficient tool for solving other equations that occur in different branches of science and technology.
Understanding accelerators to improve SDG-related outcomes for adolescents—An investigation into the nature and quantum of additive effects of protective factors to guide policy making
Authors: Sherr Lorraine , Haag Katharina , Tomlinson Mark , Rudgard William E. , Skeen Sarah , Meinck Franziska , Du Toit Stefani M. , Steventon Roberts Kathryn J. , Gordon Sarah L. , Desmond Chris , Cluver Lucie
Published: January 2023

Recent evidence has shown support for the United Nations Development Programme (UNDP) accelerator concept, which highlights the need to identify interventions or programmatic areas that can affect multiple sustainable development goals (SDGs) at once to boost their achievement. These data have also clearly shown enhanced effects when interventions are used in combination, above and beyond the effect of single interventions. However, detailed knowledge is now required on optimum combinations and relative gain in order to derive policy guidance. Which accelerators work for which outcomes, what combinations are optimum, and how many combinations are needed to maximise effect? The current study utilised pooled data from the Young Carers (n= 1402) and Child Community Care (n= 446) studies. Data were collected at baseline (n= 1848) and at a 1 to 1.5- year follow-up (n= 1740) from children and young adolescents aged 9–13 years, living in South Africa. Measures in common between the two databases were used to generate five accelerators (caregiver praise, caregiver monitoring, food security, living in a safe community, and access to community-based organizations) and to investigate their additive effects on 14 SDG-related outcomes. Predicted probabilities and predicted probability differences were calculated for each SDG outcome under the presence of none to five accelerators to determine optimal combinations. Results show that various accelerator combinations are effective, though different combinations are needed for different outcomes. Some accelerators ramified across multiple outcomes. Overall, the presence of up to three accelerators was associated with marked improvements over multiple outcomes. The benefit of targeting access to additional accelerators, with additional costs, needs to be weighed against the relative gains to be achieved with high quality but focused interventions. In conclusion, the current data show the detailed impact of various protective factors and provides implementation guidance for policy makers in targeting and distributing interventions to maximise effect and expenditure. Future work should investigate multiplicative effects and synergistic interactions between accelerators.
GenPADS: Reinforcing politeness in an end-to-end dialogue system
Authors: Mishra Kshitij , Firdaus Mauajama , Ekbal Asif
Published: January 2023

In a task-oriented dialogue setting, user’s mood and demands can change in an ongoing dialogue, which may lead to a non-informative conversation or may result in conversation drop-off. To rectify such scenarios, a conversational agent should be able to learn the user’s behaviour online, and form informative, empathetic and interactive responses. To incorporate these three aspects, we propose a novel end-to-end dialogue system GenPADS. First, we build and train two models, viz. a politeness classifier to extract polite information present in user’s and agent’s utterances and a generation model (G) to generate varying but semantically correct responses. We then incorporate both of these models in a reinforcement learning (RL) setting using two different politeness oriented reward algorithms to adapt and generate polite responses. To train our politeness classifier, we annotate recently released Taskmaster dataset into four fine-grained classes depicting politeness and impoliteness. Further, to train our generator model, we prepare a GenDD dataset using the same Taskmaster dataset. Lastly, we train GenPADS and perform automatic and human evaluation by building seven different user simulators. Detailed analysis reveals that GenPADS performs better than the two considered baselines,viz. a transformer based seq2seq generator model for user’s and agent’s utterance and a retrieval based politeness adaptive dialogue system (PADS).
Patterns and drivers of benthic macroinvertebrate assemblages in the kelp forests of southern Patagonia
Authors: Friedlander Alan M. , Ballesteros Enric , Caselle Jennifer E. , Hüne Mathias , Adler Alyssa M. , Sala Enric
Published: January 2023

The kelp forests of southern Patagonia have a large diversity of habitats, with remote islands, archipelagos, peninsulas, gulfs, channels, and fjords, which are comprised of a mixture of species with temperate and sub-Antarctic distributions, creating a unique ecosystem that is among the least impacted on Earth. We investigated the distribution, diversity, and abundance of marine macroinvertebrate assemblages from the kelp forests of southern Patagonia over a large spatial scale and examined the environmental drivers contributing to the observed patterns in assemblage composition. We analyzed data from 120 quantitative underwater transects (25 x 2 m) conducted within kelp forests in the southern Patagonian fjords in the Kawésqar National Reserve (KNR), the remote Cape Horn (CH) and Diego Ramírez (DR) archipelagos of southern Chile, and the Mitre Peninsula (MP) and Isla de los Estados (IE) in the southern tip of Argentina. We observed rich assemblages of macroinvertebrates among these kelp forests, with a total of 185 unique taxa from 10 phyla and 23 classes/infraorders across the five regions. The number of taxa per transect was highest at IE, followed by MP, CH, and KNR, with the lowest number recorded at DR. The trophic structure of the macroinvertebrate assemblages was explained mostly by wave exposure (28% of the variation), followed by salinity (12%) and the KNR region (11%). KNR was most distinct from the other regions with a greater abundance of deposit feeders, likely driven by low salinity along with high turbidity and nutrients from terrigenous sources and glacial melt. Our study provides the first broad-scale description of the benthic assemblages associated with kelp forests in this vast and little-studied region and helps to establish baselines for an area that is currently lightly influenced by local anthropogenic factors and less impacted by climate change compared with other kelp forests globally.
Exploring service users experiences of remotely delivered CBT interventions in primary care during COVID-19: An interpretative phenomenological analysis
Authors: Finazzi Emilia , MacLeod Eilidh , MacBeth Angus
Published: January 2023

Primary Care Mental Health Services (PMHCS) aim to provide accessible and effective psychological interventions. However, there is a scarcity of qualitative research focused on patients’ experiences. Service users’ experience can inform development of accessible, high-quality mental health services. Nine semi-structured interviews were analysed from Primary Care Mental Health users in Northern Scotland using Interpretative Phenomenological Analysis (IPA). Four superordinate themes were generated: Orientating to treatment, Intervention features, Change enablers, and Impact. The results identified both facilitators and barriers associated with access and psychological change; and narratives around CBT acceptability, outcomes and remote delivery. The role of GPs emerged as a key determinant of access to PMHCS. The therapeutic relationship contributed to person-centred care provision, idiosyncratic change processes and self-empowerment. A personal commitment to engage with homework was described as a crucial change enabler. Findings are discussed in relation to existing literature, practical implications and suggestions for future research.
Hypertension in an Emergency Department Population in Moshi, Tanzania; A Qualitative Study of Barriers to Hypertension Control
Authors: Galson Sophie W. , Pesambili Msafiri , Vissoci Joao Ricardo Nickenig , Manavalan Preeti , Hertz Julian T. , Temu Gloria , Staton Catherine A. , Stanifer John W.
Published: January 2023

Background

Sub-Saharan Africa has a high prevalence of hypertension with a low rate of awareness, treatment adherence, and control. The emergency department (ED) may represent a unique opportunity to improve hypertension screening, awareness, and linkage to care. We conducted a qualitative study among hypertensive patients presenting to the ED and their healthcare providers to determine barriers to hypertension care and control.

Methods

In northern Tanzania, between November and December 2017, we conducted three focus group discussions among patients with hypertension presenting to the emergency department and three in-depth interviews among emergency department physicians. In our study, hypertension was defined as a single blood pressure of ≥160/100 mm Hg or a two-time average of ≥140/90 mm Hg. Barriers to care were identified by thematic analysis applying an inductive approach within the framework method.

Results

We enrolled 24 total patients into three focus groups and performed three in-depth interviews with individual providers. Thematic analysis identified two major domains: 1) patient knowledge, attitudes, and practices, and 2) structural barriers to hypertension care. Four major themes emerged within the knowledge, attitudes, and practices domain, including disease chronicity, provider communication, family support, and fear-based attitudes. Within the structural domain, several themes emerged that identified barriers that impeded hypertension follow-up care and self-management, including cost, access to care, and transportation and wait time.

Conclusion

Patients and physicians identified multiple barriers and facilitators to hypertension care. These perspectives may be helpful to design emergency department-based interventions that target blood pressure control and linkage to outpatient care.
A novel hybrid PSO based on levy flight and wavelet mutation for global optimization
Authors: Gao Yong , Zhang Hao , Duan Yingying , Zhang Huaifeng
Published: January 2023

The concise concept and good optimization performance are the advantages of particle swarm optimization algorithm (PSO), which makes it widely used in many fields. However, when solving complex multimodal optimization problems, it is easy to fall into early convergence. The rapid loss of population diversity is one of the important reasons why the PSO algorithm falls into early convergence. For this reason, this paper attempts to combine the PSO algorithm with wavelet theory and levy flight theory to propose a new hybrid algorithm called PSOLFWM. It applies the random wandering of levy flight and the mutation operation of wavelet theory to enhance the population diversity and seeking performance of the PSO to make it search more efficiently in the solution space to obtain higher quality solutions. A series of classical test functions and 19 optimization algorithms proposed in recent years are used to evaluate the optimization performance accuracy of the proposed method. The experimental results show that the proposed algorithm is superior to the comparison method in terms of convergence speed and convergence accuracy. The success of the high-dimensional function test and dynamic shift performance test further verifies that the proposed algorithm has higher search stability and anti-interference performance than the comparison algorithm. More importantly, both t-Test and Wilcoxon’s rank sum test statistical analyses were carried out. The results show that there are significant differences between the proposed algorithm and other comparison algorithms at the significance levelα= 0.05, and the performance is better than other comparison algorithms.
Fatigue and associated factors among adult cancer patients receiving cancer treatment at oncology unit in Amhara region, Ethiopia
Authors: Animaw Lingerew , Woldegiorgis Abate Teshager , Endeshaw Destaw , Tsegaye Dejen
Published: January 2023

Introduction

Fatigue is one of the most commonly and frequently reported symptoms by cancer patients. The cause of fatigue is multifactorial in origin, and its impact varies in range from affecting patients’ daily social life, and physical, mental, economic, and social well-being to becoming a threat to their quality of life. Therefore every cancer patient needs to be screened for fatigue and considered as one of the vital signs.

Objective

To assess the prevalence of fatigue and associated factors among adult cancer patients, receiving cancer treatment at the oncology unit in Amhara region, Ethiopia, 2022.

Method

Institutional-based, cross-sectional study was conducted among adult cancer patients receiving cancer treatment from May 9th–June 8th, 2022. A stratified random sampling technique was used to select study participants. Data were entered into Epi data version 4.6 and then exported to the SPSS statistical package version 23 for further analysis. Both bivariable and multivariable logistic regression analyses were carried out. P-values <0.05 in multivariable logistic regression were considered statistically significant.

Results

The prevalence of cancer-related fatigue was 77.3% at 95% CI (73.1–81.1) with nonresponse rate of 1.97% (9). Poor social support (AOR = 3.62; 95% CI: 1.53–8.60), anxiety (AOR = 3.13; 95% CI: 1.54–6.36), physical inactivity (AOR = 3.67; 95% CI: 1.74–7.54), underweight (AOR = 2.03; 95% CI: 1.05–3.90), anemia (AOR = 2.01; 95% CI: 1.04–3.90), surgery as a treatment modality (AOR = 0.21; 95% CI: 0.06–0.78), combination therapy (AOR = 3.56; 95% CI: 1.68–7.54), treatment less than 3 cycle (AOR = 4.43; 95% CI: 1.53–12.80), and treatment 3–5 cycle (AOR = 3.55; 95% CI: 1.38–9.09) were significantly associated factors with cancer related fatigue.

Conclusion

Psychosocial assessment and intervention, nutritional support, early intervention of anemia, and promoting exercise are the key elements to minimizing fatigue among cancer patients.
Coagulation measures after cardiac arrest (CMACA)
Authors: Kim Hyo Joon , Michael Kurz , Wee Jung Hee , Oh Joo Suk , Kim Won Young , Cho In Soo , Lee Mi Jin , Lee Dong Hun , Kim Yong Hwan , Youn Chun Song
Published: January 2023

Background

During cardiac arrest (CA) and after cardiopulmonary resuscitation, activation of blood coagulation and inadequate endogenous fibrinolysis occur. The aim of this study was to describe the time course of coagulation abnormalities after out-of-hospital CA (OHCA) and to examine the association with clinical outcomes in patients undergoing targeted temperature management (TTM) after OHCA.

Methods

This prospective, multicenter, observational cohort study was performed in eight emergency departments in Korea between September 2018 and September 2019. Laboratory findings from hospital admission and 24 hours after return of spontaneous circulation (ROSC) were analyzed. The primary outcome was cerebral performance category (CPC) at discharge, and the secondary outcome was in-hospital mortality.

Results

A total of 170 patients were included in this study. The lactic acid, prothrombin time (PT), activated partial thrombin time (aPTT), international normalized ratio (INR), and D-dimer levels were higher in patients with poor neurological outcomes at admission and 24 h after ROSC. The lactic acid and D-dimer levels decreased over time, while fibrinogen increased over time. PT, aPTT, and INR did not change over time. The PT at admission and D-dimer levels 24 h after ROSC were associated with neurological outcomes at hospital discharge. Coagulation-related factors were moderately correlated with the duration of time from collapse to ROSC.

Conclusion

The time-dependent changes in coagulation-related factors are diverse. Among coagulation-related factors, PT at admission and D-dimer levels 24 h after ROSC were associated with poor neurological outcomes at hospital discharge in patients treated with TTM.
Rezum water vapor thermal therapy for treatment of lower urinary tract symptoms: A retrospective single-centre analysis from a German high-volume centre
Authors: Winkler Thorben , von Klot Christoph A. J. , Madersbacher Stephan , Kuczyk Markus A. , Wolters Mathias
Published: January 2023

Objective

Rezum is a minimal invasive surgical treatment for patients with lower urinary tract symptoms (LUTS) related to benign prostatic enlargement (BPE). The aim of our study was to assess safety and efficacy of the Rezum procedure in a consecutive series of patients.

Material and methods

A retrospective study was performed in a single tertiary care hospital in patients undergoing Rezum procedure between 2018 and 2020. All patients that underwent intervention because of drug-refractory moderate to severe LUTS were assessed. Descriptive outcomes such as symptoms scores (IPSS, IPSS-QoL), peak flow in uroflowmetry (Qmax), post-micturition residual urine volume (PVR) and prostate volume (PVol) were analysed.

Results

In total, 92 Rezum procedures were performed in the observational period. All interventions were competed without device- or procedure relates adverse events. Patients achieved a significant symptom relief as measured in IPSS (50% reduction, p<0.001, n = 35) and IPSS-QoL score (53% reduction, p<0.001, n = 35). Qmax improved by 7.3 ml/s from 10.6 ± 4.2 ml/s to 17.9 ± 9.3 ml/s (p = 0.003, n = 20) were as mean PVR significantly decreased by 136 ml from 175 ± 194.1 to 39 ± 62 ml (p = 0.007, n = 20). PVol significantly decreased by 40.3% from 73.9 ± 41.2 to 44.9 ± 29 ccm (p = 0.024, n = 17). All pre-interventional catheter-depending patients (28.3% of all patient) were catheter independent after six weeks.

Conclusion

Rezum therapy is safe and effective and can be considered a viable treatment option for BPH related LUTS.
Tin filter compared to low kV protocols - optimizing sinonasal imaging in computed tomography
Authors: Schüle Simone , Strobel Joachim Rudolf Balthasar , Lorenz Kai Johannes , Beer Meinrad , Hackenbroch Carsten
Published: January 2023

Objectives

Paranasal sinus imaging due to chronic inflammatory disease is one of the most common examinations in head and neck radiology with CT imaging considered the current gold standard. In this phantom study we analyzed different low dose CT protocols in terms of image quality, radiation exposure and subjective evaluation in order to establish an optimized scanning protocol.

Methods

In a phantom study, an Alderson phantom was scanned using 12 protocols between 70–120 kV and 25–200 mAs with and without tin filtration. For all datasets, iterative reconstruction was used. Data were objectively evaluated (image noise, (dose-weighted) contrast-to-noise ratio) and for subjective evaluation an online survey using a Likert scale was performed to reach a large group of clinically experienced reader (n = 62). The protocol was considered diagnostically insufficient if the median score was 4 and above and if more than 10% of raters scored 4 and above on the Likert scale. For an interreader agreement an ICC was calculated. To compare clinical value in relation to the applied dose and the objective image parameters, we calculated a figure of merit (FOM) and ranked the protocols accordingly.

Results

There was an overall moderate agreement between the 62 readers for the 12 examined CT protocols. In this phantom study, protocols with 100 kV with spectral shaping and 50–100 mAs obtained the best results for its combination of dose, image quality and clinical information value for diagnosing sinusitis (FOM 1st– 2nd place) with the 70 kV and 50 mAs as a good alternative as well (Sinusitis: FOM shared 2nd). For preoperative planning, where a higher dose is necessary, 100 kV with spectral shaping and 100 mAs achieved the overall best results (FOM 1st place) with 70 kV and 50 mAs ranking 4th.

Conclusion

100-kV protocols with spectral shaping or low kV protocols (70 kV) with a similarly low dose showed the best figure of merit for imaging sinonasal disease and preoperative planning. With modern scanner technology available, spectral shaping or low KV protocols should be used for sinusitis imaging.
Stakeholder engagement variability across public, private and public-private partnership projects: A data-driven network-based analysis
Authors: Uddin Shahadat , Ong Stephen , Matous Petr
Published: January 2023

Stakeholder engagement is generally considered one of the most pertinent factors impacting project outcomes. However, there is lacking empirical evidence documenting patterns of stakeholder engagement and their potential differences between public, private and public-private partnership (PPP) projects. This study leverages social network research methods to capture and quantitively compare these engagement structures. Stakeholder network data were collected by an online questionnaire from 17 public, 30 private and 9 PPP projects. A series of network-based analyses were subsequently applied to the data at both the level of individual project stakeholders and entire project stakeholder ecologies. A statistically significant difference (p<0.05) exists among the network-level measures of network size, edge number, density and betweenness centralization across the three project types. Among these four network measures, the density varies significantly (p<0.05) between ‘within budget’ and cost overrun projects for the private and PPP projects. The top-5 stakeholder lists with respect to three node-level centrality values reveal distinctive differences across the three project types. To further interpret the data, exponential random graph models were also applied to determine the most statistically prevalent network motifs within each type of project. Again, statistically significant differences were found across these three project types. The findings consistently point to structural differences in patterns of stakeholder engagement across the public and private domain and illustrate the applicability of network data and analytical techniques to monitoring and managing complex webs of relationships among actors who affect and are affected by diverse types of projects.
The impact of Blackboard Collaborate breakout groups on the cognitive achievement of physical education teaching styles during the COVID-19 pandemic
Authors: Rakha Ahmed Hassan
Published: January 2023

The rapid spread of COVID-19 has forced schools and universities to close. Globally, education systems face unprecedented challenges, and learning management systems (LMS) are the only solution. The current study aimed to investigate the effectiveness of a Blackboard collaborative breakout group on the cognitive achievement of physical education teaching styles. The quasi-experimental method involved creating two groups: one experimental and one control, with the experimental group using Blackboard collaborative breakout groups and the control group relying exclusively on online lectures and continuing with the same method without breakout groups. The study sample consisted of 40 students who were randomly assigned and divided equally into the two groups. Based on the research sample, homogeneity within the group and equivalence between groups in terms of age, Grade Point Average (GPA), and high intelligence test (IQ) were evaluated. The results showed that the experimental group’s cognitive achievement was superior to that of the control group. Therefore, the design of the learning process enhances student collaboration, participation, and reinforcement. Additionally, the experimental group retained the learning outcomes for a month after the cessation of all teaching and learning processes. To conclude, giving a lecture using webinar tools such as Blackboard Collaborate Ultra does not necessarily mean achieving the intended educational goals. As a result, it is necessary to look for ways to integrate active learning strategies, such as collaborative learning, to enhance student involvement in distance learning.
An expressway traffic congestion measurement under the influence of service areas
Authors: Liao Lyuchao , Li Zhengrong , Lai Shukun , Jiang Wenxia , Zou Fumin , Yu Xiang , Xu Zhiyu
Published: January 2023

Identifying traffic congestion accurately is crucial for improving the expressway service level. Because the distributions of microscopic traffic quantities are highly sensitive to slight changes, the traffic congestion measurement is affected by many factors. As an essential part of the expressway, service areas should be considered when measuring the traffic state. Although existing studies pay increasing attention to service areas, the impact caused by service areas is hard to measure for evaluating traffic congestion events. By merging ETC transaction datasets and service area entrance data, this work proposes a traffic congestion measurement with the influence of expressway service areas. In this model, the traffic congestion with the influence of service areas is corrected by three modules: 1) the pause rate prediction module; 2) the fitting module for the relationship between effect and pause rate; 3) the measurement module with correction terms. Extensive experiments were conducted on the real dataset of the Fujian Expressway, and the results show that the proposed method can be applied to measure the effect caused by service areas in the absence of service area entry data. The model can also provide references for other traffic indicator measurements under the effect of the service area.
Study on the sustainability of ancient canal towns on the basis of the topological structure analysis of streets and lanes: A case study of the Xixing ancient town
Authors: Lv Weilu , Wang Ning , Huang Yun
Published: January 2023

In China, rapid urbanization and the decline of the canal’s shipping function have directly led to the decline of the space and style of ancient towns with canals. The ancient town of Xixing, known to be the first canal town, is located west of the Zhedong canal section of the Grand Canal. It used to be the most active transportation hub and trade transit point in the east Zhejiang Province. However, the canal is now facing problems in protection and renewal, which require urgent attention. For example, the streets of the ancient town are separated from the water system space, the self-organizing and development ability of the ancient town has weakened, and the spatial vitality is scarce. Firstly, by comparing and analyzing whether the canal is used as a road network under two different spatial scales, the area with the highest degree of spatial integration is obtained before judging whether the canal has an important influence and control on the street spaces of the ancient town. Secondly, as the canal is no longer used as a transportation network nowadays, the internal spatial structure characteristics of streets and alleys are analyzed. Finally, the topological structure analysis is carried out in the 3 km area from the border of the planning control area, and the integrated development of the ancient town space and urban transportation network is then discussed. Further, the vitality renewal strategies of the ancient town under different spatial scales are put forward to provide the empirical basis and decision-making reference for the better sustainable development of ancient towns with canals. According to research, once the ancient town is considered on a larger urban scale, the areas with the best integration and accessibility, like the water-adjoined spaces change to intersection spaces and urban road network areas. Consequently, in order to realize the sustainable development of Xixing ancient town, the city system must overcome its shortfalls in operation. The methods and conclusions in the paper can effectively contribute to the development of the ancient town. The research significantly helps to improve the average land sharing, commercial distribution, and public facilities layout in the practice of protection and development in ancient towns and provides an empirical basis and decision-making references for relevant management departments.
The importance of information acquisition to settlement services literacy for humanitarian migrants in Australia
Authors: Abood Julianne , Green Julie , Polonsky Michael J. , Woodward Kerry , Tadjoeddin Zulfan , Renzaho Andre M. N.
Published: January 2023

Background

Due to the diversity and range of services provided to humanitarian migrants during the settlement phase of migration, acquiring information across multiple service domains is intrinsic to the effective utilisation of settlement services. There are research gaps investigating how humanitarian migrants experience and navigate unfamiliar, multiple, and often complex information and service systems of host countries. This study seeks to understand the impediments to humanitarian migrants’ effective utilisation of information about settlement services and to identify strategies that can be implemented to overcome these barriers.

Methods

Service providers were purposively recruited from organisations funded by the Australian Government to deliver settlement programs. The study applied an inductive thematic analysis approach to identify key themes that emerged from the data.

Results

From the perspective of service providers, the themed findings identified how humanitarian migrants gain knowledge about services, their information needs, information seeking practices and skills, and information specific to service domains. The findings illustrate the importance of acquiring information, knowledge, and skills across multiple information platforms and service domains as being integral to the effective utilisation of settlement services for humanitarian migrants. The study identifies systemic barriers to information and service access and suggests different strategies and approaches to improve access to context specific key information. The study identifies factors that inhibit the effectiveness of the Australian settlement service provision model and emphasises the need for targeted training of mainstream referral services. The study highlights the important role that settlement service providers play as mediators of information, adept at tailoring information to humanitarian migrants’ individual and community information needs.

Conclusion

The findings provide important insights that highlight the different roles that policymakers, researchers, and service providers can play to inform new approaches that improve the effectiveness of information and settlement service provision, as part of contributing to optimum settlement outcomes for humanitarian migrants.
Neonatal palliative care: Assessing the nurses educational needs for terminally ill patients
Authors: Khraisat Omar M. , Al-Bashaireh Ahmad M. , Khafajeh Raed , Alqudah Ola
Published: January 2023

Background

For terminally sick neonates and their families, it’s crucial to provide holistic nursing care that incorporates both curative and palliative care as much as feasible. It is well known that the biggest obstacle to delivering palliative care for neonatal children is a lack of training for nurses. Aim: The aim of this research is to investigate the experiences of nurses who provide care for neonates who are terminally ill as well as their educational requirements for neonatal palliative care.

Method

A cross-sectional descriptive study was conducted among 200 nurses working in a tertiary center providing care for terminally ill neonates in Saudi Arabia. Data was collected from using Neonatal Palliative Care Questionnaire (QNPC) from January 2021 to March 2021.

Results

Two hundred nurses were surveyed (the response rate was 79%). The mean age of the 158 participants was 35.67 (standard deviation (SD): 7.43), and the majority were female (151; 95.6%). The majority were bachelor’s holders (119; 75.3%), with more than 5 years of experience in providing care for neonates (100; 63.3%). Most of the participants reported not receiving any education about palliative care (115; 72.8%). Nurses reported a moderate level of experience in all areas of neonatal palliative care. The total mean score of palliative care experiences of neonates was 3.42 (SD: 1.35). However, the majority of nurses reported little experience discussing the transition period to palliative care for neonates 2.95 (SD: 1.93), the discussion of code status (DNR) during terminal illness of neonates 3.11 (SD: 1.54) and spiritual support 2.90 (SD: 1.55).

Conclusion

The assessment of the fundamental skills of neonatal palliative care by nurses was insufficient. To enhance the quality of care, it is crucial to incorporate education on neonatal palliative care into programs for nursing staff development.