bluuebunny/crossref_metadata_2025 huggingface dataset:
Future Impacts of Land Use Change on Ecosystem Services under Different Scenarios in the Ecological Conservation Area, Beijing, China
Authors: Li Zuzheng , Cheng Xiaoqin , Han Hairong
Published: May 2020

Ecosystem services (ES), defined as benefits provided by the ecosystem to society, are essential to human well-being. However, it remains unclear how they will be affected by land-use changes due to lack of knowledge and data gaps. Therefore, understanding the response mechanism of ecosystem services to land-use change is critical for developing systematic and sound land planning. In this study, we aimed to explore the impacts of land-use change on the three ecosystem services, carbon storage (CS), flood regulation (FR), and soil conservation (SC), in the ecological conservation area of Beijing, China. We first projected land-use changes from 2015 to 2030, under three scenarios, i.e., Business as Usual (BAU), Ecological Land Protection (ELP), and Rapid Economic Development (RED), by interactively integrating the Markov model (Quantitative simulation) with the GeoSOS-FLUS model (Spatial arrangement), and then quantified the three ecosystem services by using a spatially explicit InVEST model. The results showed that built-up land would have the most remarkable growth during 2015–2030 under the RED scenario (2.52% increase) at the expense of cultivated and water body, while forest land is predicted to increase by 152.38 km2 (1.36% increase) under the ELP scenario. The ELP scenario would have the highest amount of carbon storage, flood regulation, and soil conservation, due to the strict protection policy on ecological land. The RED scenario, in which a certain amount of cultivated land, water body, and forest land is converted to built-up land, promotes soil conservation but triggers greater loss of carbon storage and flood regulation capacity. The conversion between land-use types will affect trade-offs and synergies among ecosystem services, in which carbon storage would show significant positive correlation with soil conservation through the period of 2015 to 2030, under all scenarios. Together, our results provide a quantitative scientific report that policymakers and land managers can use to identify and prioritize the best practices to sustain ecosystem services, by balancing the trade-offs among services.
Hydrodynamic Dispersion in Porous Media and the Significance of Lagrangian Time and Space Scales
Authors: Nguyen Vi , Papavassiliou Dimitrios V.
Published: May 2020

Transport in porous media is critical for many applications in the environment and in the chemical process industry. A key parameter for modeling this transport is the hydrodynamic dispersion coefficient for particles and scalars in a porous medium, which has been found to depend on properties of the medium structure, on the dispersing compound, and on the flow field characteristics. Previous studies have resulted in suggestions of different equation forms, showing the relationship between the hydrodynamic dispersion coefficient for various types of porous media in various flow regimes and the Peclet number. The Peclet number is calculated based on a Eulerian length scale, such as the diameter of the spheres in packed beds, or the pore diameter. However, the nature of hydrodynamic dispersion is Lagrangian, and it should take the molecular diffusion effects, as well as the convection effects, into account. This work shifts attention to the Lagrangian time and length scales for the definition of the Peclet number. It is focused on the dependence of the longitudinal hydrodynamic dispersion coefficient on the effective Lagrangian Peclet number by using a Lagrangian length scale and the effective molecular diffusivity. The lattice Boltzmann method (LBM) was employed to simulate flow in porous media that were constituted by packed spheres, and Lagrangian particle tracking (LPT) was used to track the movement of individual dispersing particles. It was found that the hydrodynamic dispersion coefficient linearly depends on the effective Lagrangian Peclet number for packed beds with different types of packing. This linear equation describing the dependence of the dispersion coefficient on the effective Lagrangian Peclet number is both simpler and more accurate than the one formed using the effective Eulerian Peclet number. In addition, the slope of the line is a characteristic coefficient for a given medium.
Nutrient Patchiness, Phytoplankton Surge-Uptake, and Turbulent History: A Theoretical Approach and Its Experimental Validation
Authors: Schapira Mathilde , Seuront Laurent
Published: May 2020

Despite ample evidence of micro- and small-scale (i.e., millimeter- to meter-scale) phytoplankton and zooplankton patchiness in the ocean, direct observations of nutrient distributions and the ecological importance of this phenomenon are still relatively scarce. In this context, we first describe a simple procedure to continuously sample nutrients in surface waters, and subsequently provide evidence of the existence of microscale distribution of ammonium in the ocean. We further show that ammonium is never homogeneously distributed, even under very high conditions of turbulence. Instead, turbulence intensity appears to control nutrient patchiness, with a more homogeneous or a more heterogeneous distribution observed under high and low turbulence intensities, respectively, under the same concentration in nutrient. Based on a modelling procedure taking into account the stochastic properties of intermittent nutrient distributions and observations carried out on natural phytoplankton communities, we introduce and verify the hypothesis that under nutrient limitation, the “turbulent history” of phytoplankton cells, i.e., the turbulent conditions they experienced in their natural environments, conditions their efficiency to uptake ephemeral inorganic nitrogen patches of different concentrations. Specifically, phytoplankton cells exposed to high turbulence intensities (i.e., more homogeneous nutrient distribution) were more efficient to uptake high concentration nitrogen pulses (2 µM). In contrast, under low turbulence conditions (i.e., more heterogeneous nutrient distribution), uptake rates were higher for low concentration nitrogen pulses (0.5 µM). These results suggest that under nutrient limitation, natural phytoplankton populations respond to high turbulence intensities through a decrease in affinity for nutrients and an increase in their transport rate, and vice versa.
Droplet Impact on Suspended Metallic Meshes: Effects of Wettability, Reynolds and Weber Numbers
Authors: Vontas Konstantinos , Boscariol Cristina , Andredaki Manolia , Georgoulas Anastasios , Crua Cyril , Walther Jens Honoré , Marengo Marco
Published: May 2020

Liquid penetration analysis in porous media is of great importance in a wide range of applications such as ink jet printing technology, painting and textile design. This article presents an investigation of droplet impingement onto metallic meshes, aiming to provide insights by identifying and quantifying impact characteristics that are difficult to measure experimentally. For this purpose, an enhanced Volume-Of-Fluid (VOF) numerical simulation framework is utilised, previously developed in the general context of the OpenFOAM CFD Toolbox. Droplet impacts on metallic meshes are performed both experimentally and numerically with satisfactory degree of agreement. From the experimental investigation three main outcomes are observed—deposition, partial imbibition, and penetration. The penetration into suspended meshes leads to spectacular multiple jetting below the mesh. A higher amount of liquid penetration is linked to higher impact velocity, lower viscosity and larger pore size dimension. An estimation of the liquid penetration is given in order to evaluate the impregnation properties of the meshes. From the parametric analysis it is shown that liquid viscosity affects the adhesion characteristics of the drops significantly, whereas droplet break-up after the impact is mostly controlled by surface tension. Additionally, wettability characteristics are found to play an important role in both liquid penetration and droplet break-up below the mesh.
GC–MS Analysis, Antioxidant and Antimicrobial Activities of Achillea Odorata Subsp. Pectinata and Ruta Montana Essential Oils and Their Potential Use as Food Preservatives
Authors: Benali Taoufiq , Habbadi Khaoula , Khabbach Abdelmajid , Marmouzi Ilias , Zengin Gokhan , Bouyahya Abdelhakim , Chamkhi Imane , Chtibi Houda , Aanniz Tarik , Achbani El Hassan , Hammani Khalil
Published: May 2020

In order to discover new natural resources with biological properties, the chemical composition, the antioxidant and antimicrobial activities, and the potential use as food preservative of essential oils of Moroccan Achillea odorata subsp. pectinata (AOpEO) and Ruta montana (RMEO) were studied. Gas chromatography-mass spectrometry (GC-MS) analysis revealed the presence of 21 and 25 compounds in AOpEO and RMEO, respectively. The results showed that the major compounds of AOpEO are camphor (45.01%), bornyl acetate (15.07%), borneol (11.33%), β-eudesmol (4.74%), camphene (3.58%), and 1.8-cineole (eucalyptol) (2.96%), whereas 2-undecanone (63.97%), camphor (3.82%) and cyclopropanecarboxylic acid (3.66%) were the main components of RMEO. The antioxidant activities were evaluated by diphenylpicrylhydraziyl radical (DPPH) and reducing power assays. The antimicrobial activities of essential oils were tested against bacterial strains and food contaminant yeast using agar disc diffusion and microdilution methods. A significant antimicrobial activity of AOpEO was observed against Bacillus subtilis, Proteus mirabilis and Candida albicans, compared to RMEO. The efficacy of AOpEO was also evaluated in model food systems (cabbage and barley) artificially inoculated during storage. The results found that the adding of a minimal inhibitory concentration (MIC) and 4× MIC were potent in decreasing the Proteus mirabilis growth in food model systems. Our findings suggested that AOpEO may be potentially used as an alternative food preservative.
Dynamic Modeling of Power Outages Caused by Thunderstorms
Authors: Alpay Berk A. , Wanik David , Watson Peter , Cerrai Diego , Liang Guannan , Anagnostou Emmanouil
Published: May 2020

Thunderstorms are complex weather phenomena that cause substantial power outages in a short period. This makes thunderstorm outage prediction challenging using eventwise outage prediction models (OPMs), which summarize the storm dynamics over the entire course of the storm into a limited number of parameters. We developed a new, temporally sensitive outage prediction framework designed for models to learn the hourly dynamics of thunderstorm-caused outages directly from weather forecasts. Validation of several models built on this hour-by-hour prediction framework and comparison with a baseline model show abilities to accurately report temporal and storm-wide outage characteristics, which are vital for planning utility responses to storm-caused power grid damage.
Oscillating Cosmological Force Modifies Newtonian Dynamics
Authors: Smolyaninov Igor
Published: May 2020

In the Newtonian limit of general relativity a force acting on a test mass in a central gravitational field is conventionally defined by the attractive Newtonian gravity (inverse square) term plus a small repulsive cosmological force, which is proportional to the slow acceleration of the universe expansion. In this paper we considered the cosmological-force correction due to fast quantum oscillations of the universe scale factor as a potential solution of the cosmological constant problem. These fast fluctuations of the cosmological scale factor violate Lorentz invariance at the Planck scale, and they induce strong changes to the current sign and magnitude of the average cosmological force, thus making it one of the potential probable causes for the modification of Newtonian dynamics in galaxy-scale systems. The modified cosmological force may be responsible for the recently discovered “cosmic-clock” behavior of disk galaxies in the low-redshift universe. The obtained results have strong implications for astroparticle physics since they demonstrate that typical galaxy rotation curves may be obtained without (or almost without) dark-matter particles.
A Method for Quantitative Interpretation of Stationary Thermal Fields for Layered Media
Authors: Ladovskii Igor V. , Martyshko Petr S. , Tsidaev Alexander G. , Byzov Denis D.
Published: May 2020

A new method to solve thermal conjugacy problems is presented for layered models with a thermal conductivity jump at their boundaries. The purpose of this method is to approximate the inverse thermal conductivity coefficient, which has breaks, by using a combination of step functions. A generalized continuous operator is constructed in a continuous space of piecewise–homogeneous media. We obtained an analytical solution for the stationary problem of heat conjugacy in the layered model with finite thickness and with Dirichlet–Neumann conditions at the external boundaries. An algorithm was constructed for downward continuation of the heat flux to depths that correspond to the top of the mantle layer. The advantages of this method are illustrated by testing the crustal seismic, gravity and geothermal data of a study area in the Urals and neighboring regions of Russia. We examined statistical relations between density and thermal parameters and determined heat flux components for the crust and the mantle. The method enables a downward continuation of the heat flux to the base of the upper mantle and allows us to determine the thermal effects of the lateral and vertical features of deep tectonic structures.
The Effect of Decision Training, from a Cognitive Perspective, on Decision-Making in Volleyball: A Systematic Review and Meta-Analysis
Authors: Conejero Suárez Manuel , Prado Serenini Antonio Luiz , Fernández-Echeverría Carmen , Collado-Mateo Daniel , Moreno Arroyo M. Perla
Published: May 2020

Over the past few decades there has been great interest in the study of cognitive processes, and specifically decision-making, from a cognitive perspective. The aim of the present study was to systematically review the scientific literature on the effect of decision training interventions/programs, from a cognitive perspective, on the decision-making of volleyball players. The systematic search was carried out in five scientific electronic databases according to PRISMA guidelines Web of Science (WOS), Pubmed (Medline), Scopus, SportDiscus and Google Scholar. A total of eight studies met the inclusion criteria. The main finding of the meta-analysis was that the use of decision-making training programs/interventions led to significant improvements in volleyball players’ decision-making (Standardized mean difference = 0.94 with 95% confidence interval from 0.63 to 1.25), compared to normal active volleyball training. In addition, the heterogeneity of the interventions was low (I2 = 0%). From the results of the studies analyzed, we recommend using decisional interventions or training, both as part of normal active training or complementary to it, to improve the decision-making of the players, thus optimizing their ability to perceive and process relevant stimuli, and then generate quick and effective responses. These findings can be useful in the process of sports training.
In Silico Subtractive Proteomics Approach for Identification of Potential Drug Targets in Staphylococcus saprophyticus
Authors: Shahid Farah , Ashfaq Usman Ali , Saeed Sania , Munir Samman , Almatroudi Ahmad , Khurshid Mohsin
Published: May 2020

Staphylococcus saprophyticus is a uropathogenic bacteria responsible for acute urinary tract infections (UTIs) mainly in young female patients. Patients suffering from urinary catheterization, pregnant patients, the elderly as well as those with nosocomial UTIs are at greater risk of the colonizing S. saprophyticus infection. The causative factors include benign prostatic hyperplasia, indwelling catheter, neurogenic bladder, pregnancy, and history of frequent UTIs. Recent findings have exhibited that S. saprophyticus is resistant to several antimicrobial agents. Moreover, there is a global concern regarding the increasing level of antimicrobial resistance, which leads to treatment failure and reduced effectiveness of broad-spectrum antimicrobials. Therefore, a novel approach is being utilized to combat resistant microbes since the past few years. Subtractive proteome analysis has been performed with the entire proteome of S. saprophyticus strain American Type Culture Collection (ATCC) 15305 using several bioinformatics servers and software. The proteins that were non-homologous to humans and bacteria were identified for metabolic pathway analysis. Only four cytoplasmic proteins were found possessing the potential of novel drug target candidates. The development of innovative therapeutic agents by targeting the inhibition of any essential proteins may disrupt the metabolic pathways specific to the pathogen, thus causing destruction as well as eradication of the pathogen from a particular host. The identified targets can facilitate in designing novel and potent drugs against S. saprophyticus strain ATCC 15305.
The Voice of Drug Consumers: Online Textual Review Analysis Using Structural Topic Model
Authors: He Lifeng , Han Dongmei , Zhou Xiaohang , Qu Zheng
Published: May 2020

Many web-based pharmaceutical e-commerce platforms allow consumers to post open-ended textual reviews based on their purchase experiences. Understanding the true voice of consumers by analyzing such a large amount of user-generated content is of great significance to pharmaceutical manufacturers and e-commerce websites. The aim of this paper is to automatically extract hidden topics from web-based drug reviews using the structural topic model (STM) to examine consumers’ concerns when they buy drugs online. The STM is a probabilistic extension of Latent Dirichlet Allocation (LDA), which allows the consolidation of document-level covariates. This innovation allows us to capture consumer dissatisfaction along with their dynamics over time. We extract 12 topics, and five of them are negative topics representing consumer dissatisfaction, whose appearances in the negative reviews are substantially higher than those in the positive reviews. We also come to the conclusion that the prevalence of these five negative topics has not decreased over time. Furthermore, our results reveal that the prevalence of price-related topics has decreased significantly in positive reviews, which indicates that low-price strategies are becoming less attractive to customers. To the best of our knowledge, our work is the first study using STM to analyze the unstructured textual data of drug reviews, which enhances the understanding of the aspects of drug consumer concerns and contributes to the research of pharmaceutical e-commerce literature.
Profiling Dating Apps Users: Sociodemographic and Personality Characteristics
Authors: Castro Ángel , Barrada Juan Ramón , Ramos-Villagrasa Pedro J. , Fernández-del-Río Elena
Published: May 2020

The development of new technologies, the expansion of the Internet, and the emergence of dating apps (e.g., Tinder, Grindr) in recent years have changed the way to meet and approach potential romantic and/or sexual partners. The recent phenomenon has led to some gaps in the literature on individual differences (sociodemographic variables and personality traits) between users (previous and current users) and non-users of dating apps. Thus, the aim of this study was to analyze the relationship between using dating apps, sociodemographics (gender, age, sexual orientation, and relationship status), and bright and dark personality traits. Participants were 1705 university students (70% women, 30% men), aged between 18 and 26 (M = 20.60, SD = 2.09), who completed several online questionnaires. Through multinomial logistic regression analyses, it was found that men, older youth, and members of sexual minorities were more likely to be current and previous dating apps users. Being single and higher scores in open-mindedness were associated with higher probability to be current dating apps user. The dark personality showed no predictive ability. The discussion highlights the usefulness of knowing and considering the sociodemographic background and the characteristics of personality patterns in the design and implementation of preventive and promotion programs of healthy romantic and sexual relationships to improve people’s better health and well-being.
Coping Styles in Pregnancy, Their Demographic and Psychological Influences, and Their Association with Postpartum Depression: A Longitudinal Study of Women in China
Authors: Yu Min , Gong Wenjie , Taylor Beck , Cai Yiyuan , Xu Dong (Roman)
Published: May 2020

We aimed to investigate the coping styles of Chinese pregnant women, identify factors associated with coping and further explore the effect of coping during pregnancy on postpartum depression. A longitudinal study was performed from early pregnancy to six-week postpartum. A total of 1126 women were recruited by convenience sampling and participants who completed eight questionnaires at four time points were included (three self-developed questionnaires, Coping Style Questionnaire, Generalized Anxiety Disorder-7, Brief Resilience Scale, Rosenberg Self-esteem Scale, Edinburgh Postnatal Depression Scale) (n = 615). Linear regression analyses were used to identify the possible factors for coping and their association with postpartum depression. The mean scores of positive coping and negative coping were 2.03 and 1.21, respectively. Women with a higher educational level scored higher on both positive and negative coping in pregnancy. Resilience was associated with both positive and negative coping, while self-esteem only related to positive coping (p < 0.05). Postpartum depression was associated with both positive and negative coping (p < 0.05). The women in our study reported using positive coping styles more than negative coping antenatally. Positive and negative coping behaviors could be used simultaneously. Increasing self-esteem and resilience antenatally might promote more positive coping and further reduce the occurrence of postpartum depression.
Prepregnancy Endocrine, Autoimmune Disorders and the Risks of Gestational Hypertension-Preeclampsia in Primiparas: A Nationwide Population-Based Study in Taiwan
Authors: Pan Mei-Lien , Chen Li-Ru , Tsao Hsiao-Mei , Chen Kuo-Hu
Published: May 2020

(1) Objective: To assess the risks of gestational hypertension/preeclampsia (GH-PE) in women with prepregnancy endocrine and autoimmune disorders such as polycystic ovarian syndrome (PCOS) and systemic lupus erythematosus (SLE). (2) Methods: In a nationwide population-based longitudinal study, data were retrieved from the 1998 to 2012 Taiwan National Health Insurance Research Database. ICD9-CM codes 256.4, 710.0, and 642.X were identified for the corresponding diagnoses of PCOS, SLE, and GH-PE, respectively, which were further confirmed by inspection of medical claims data for ultrasonography findings, laboratory tests, blood pressure measurements and examinations of urine protein to ensure the accuracy of the diagnoses. To clarify the risks of primiparous GH-PE, the study excluded women diagnosed with PCOS or SLE at <15 or >45 years of age, pre-existing chronic hypertension, GH-PE before PCOS and SLE, and abortion or termination before 20 weeks’ gestation. For women affected by prepregnancy PCOS or SLE individually, each pregnant woman was age-matched to four pregnant women without PCOS or SLE. Logistic regression analyses were applied to report odds ratios (ORs) for the risks of GH-PE after adjustment for age, occupation, urbanization, economic status, and other co-morbidities. (3) Results: Among 8070 and 2430 women with prepregnancy PCOS and SLE retrieved from a population of 1,000,000 residents, 1953 (24.20%) and 820 (33.74%) had subsequent primiparous pregnancies that were analyzable and compared with 7812 and 3280 pregnancies without prepregnancy PCOS and SLE, respectively. GH-PE occurred more frequently in pregnancies with prepregnancy PCOS (5.79% vs. 2.23%, p < 0.0001) and SLE (3.41% vs. 1.80%, p < 0.01) as compared to those without PCOS and SLE. Further analysis revealed that prepregnancy PCOS (adjusted OR = 2.36; 95%CI: 1.83–3.05) and SLE (adjusted OR = 1.95; 95%CI: 1.23–3.10) were individually associated with GH-PE. The risk of GH-PE was not reduced in women with prepregnancy PCOS receiving metformin treatment (p = 0.22). (4) Conclusions: Prepregnancy PCOS and SLE are independent and significant risk factors for the occurrence of GH-PE. Because the peripartum complications are much higher among pregnancies with GH-PE, the at-risk woman should be informed and well-prepared during her pregnancy and delivery.
Parents’ Experience and Psychoeducation Needs When Supporting a Young Person Who Self-Harms
Authors: Krysinska Karolina , Curtis Sophie , Lamblin Michelle , Stefanac Nina , Gibson Kerry , Byrne Sadhbh , Thorn Pinar , Rice Simon M. , McRoberts Alison , Ferrey Anne , Perry Yael , Lin Ashleigh , Hetrick Sarah , Hawton Keith , Robinson Jo
Published: May 2020

Background: Self-harm in young people can have a substantial negative impact on the well-being and functioning of parents and other carers. The “Coping with Self-Harm” booklet was originally developed in the UK as a resource for parents and carers of young people who self-harm, and an adaptation study of this resource was conducted in Australia. This paper presents qualitative analysis of interviews with parents about their experiences and psychoeducational needs when supporting a young person who engages in self harm. Methods: The qualitative study drew on semi-structured individual and group interviews with parents (n = 19 participants) of young people who self-harm. Data were analysed using Thematic Analysis. Results: The analysis identified six themes: (1) the discovery of self-harm, (2) challenges in the parent-young person relationship, (3) parents’ need to understand self-harm, (4) parents’ emotional reactions to self-harm, (5) the importance of self-care and help-seeking among parents, and (6) the need for psychoeducational resources. Conclusion: The study highlights the need for support for parents and carers of young people who engage in self-harm, including development and adaptation of resources, such as the “Coping with Self-Harm” booklet, of which an Australian version has now been developed.
Microbial Transglutaminase as a Tool to Improve the Features of Hydrocolloid-Based Bioplastics
Authors: Giosafatto C. Valeria L. , Fusco Antonio , Al-Asmar Asmaa , Mariniello Loredana
Published: May 2020

Several proteins from animal and plant origin act as microbial transglutaminase substrate, a crosslinking enzyme capable of introducing isopeptide bonds into proteins between the aminoacids glutamines and lysines. This feature has been widely exploited to modify the biological properties of many proteins, such as emulsifying, gelling, viscosity, and foaming. Besides, microbial transglutaminase has been used to prepare bioplastics that, because made of renewable molecules, are able to replace the high polluting plastics of petrochemical origin. In fact, most of the time, it has been shown that the microbial enzyme strengthens the matrix of protein-based bioplastics, thus, influencing the technological characteristics of the derived materials. In this review, an overview of the ability of many proteins to behave as good substrates of the enzyme and their ability to give rise to bioplastics with improved properties is presented. Different applications of this enzyme confirm its important role as an additive to recover high value-added protein containing by-products with a double aim (i) to produce environmentally friendly materials and (ii) to find alternative uses of wastes as renewable, cheap, and non-polluting sources. Both principles are in line with the bio-economy paradigm.
Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes
Authors: Matutino Bastos Tanira , Botelho Pereira Soares Milena , Haddad Franco Caio , Alcântara Laura , Antonini Lorenzo , Sabatino Manuela , Mautone Nicola , Holanda Freitas-Junior Lucio , Moraes Carolina Borsoi , Ragno Rino , Rotili Dante , Schenkman Sergio , Mai Antonello , Silvio Moretti Nilmar
Published: May 2020

Chagas disease is an illness caused by the protozoan parasite Trypanosoma cruzi, affecting more than 7 million people in the world. Benznidazole and nifurtimox are the only drugs available for treatment and in addition to causing several side effects, are only satisfactory in the acute phase of the disease. Sirtuins are NAD+-dependent deacetylases involved in several biological processes, which have become drug target candidates in various disease settings. T. cruzi presents two sirtuins, one cytosolic (TcSir2rp1) and the latter mitochondrial (TcSir2rp3). Here, we characterized the effects of human sirtuin inhibitors against T. cruzi sirtuins as an initial approach to develop specific parasite inhibitors. We found that, of 33 compounds tested, two inhibited TcSir2rp1 (15 and 17), while other five inhibited TcSir2rp3 (8, 12, 13, 30, and 32), indicating that specific inhibitors can be devised for each one of the enzymes. Furthermore, all inhibiting compounds prevented parasite proliferation in cultured mammalian cells. When combining the most effective inhibitors with benznidazole at least two compounds, 17 and 32, demonstrated synergistic effects. Altogether, these results support the importance of exploring T. cruzi sirtuins as drug targets and provide key elements to develop specific inhibitors for these enzymes as potential targets for Chagas disease treatment.
A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease
Authors: Prestes Priscilla R. , Maier Michelle C. , Woods Bradley A. , Charchar Fadi J.
Published: May 2020

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompasses many diseased states, including hypertension, coronary artery disease and atherosclerosis. Studies in animal models and human studies have elucidated the contribution of many genetic factors, including non-coding RNAs. Non-coding RNAs are RNAs not translated into protein, involved in gene expression regulation post-transcriptionally and implicated in CVD. Of these, circular RNAs (circRNAs) and microRNAs are relevant. CircRNAs are created by the back-splicing of pre-messenger RNA and have been underexplored as contributors to CVD. These circRNAs may also act as biomarkers of human disease, as they can be extracted from whole blood, plasma, saliva and seminal fluid. CircRNAs have recently been implicated in various disease processes, including hypertension and other cardiovascular disease. This review article will explore the promising and emerging roles of circRNAs as potential biomarkers and therapeutic targets in CVD, in particular hypertension.
Cyclophilin A Promotes Inflammation in Acute Kidney Injury but Not in Renal Fibrosis
Authors: Leong Khai Gene , Ozols Elyce , Kanellis John , Nikolic-Paterson David J. , Ma Frank Y.
Published: May 2020

Cyclophilin A (CypA) is a highly abundant protein in the cytoplasm of most mammalian cells. Beyond its homeostatic role in protein folding, CypA is a Damage-Associated Molecular Pattern which can promote inflammation during tissue injury. However, the role of CypA in kidney disease is largely unknown. This study investigates the contribution of CypA in two different types of kidney injury: acute tubular necrosis and progressive interstitial fibrosis. CypA (Ppia) gene deficient and wild type (WT) littermate controls underwent bilateral renal ischaemia/reperfusion injury (IRI) and were killed 24 h later or underwent left unilateral ureteric obstruction (UUO) and were killed 7 days later. In the IRI model, CypA−/− mice showed substantial protection against the loss of renal function and from tubular cell damage and death. This was attributed to a significant reduction in neutrophil and macrophage infiltration since CypA−/− tubular cells were not protected from oxidant-induced cell death in vitro. In the UUO model, CypA−/− mice were not protected from leukocyte infiltration or renal interstitial fibrosis. In conclusion, CypA promotes inflammation and acute kidney injury in renal IRI, but does not contribute to inflammation or interstitial fibrosis in a model of progressive kidney fibrosis.
Body Composition Impact on Sleep in Young Adults: The Mediating Role of Sedentariness, Physical Activity, and Diet
Authors: Carneiro-Barrera Almudena , Amaro-Gahete Francisco J. , Acosta Francisco M. , Ruiz Jonatan R.
Published: May 2020

Obesity and sleep disturbances are both related to endocrine and metabolic alterations, cardiovascular disease, and impaired daytime functioning and mood. However, the bidirectional relationship between these conditions and the underlying mechanisms still remain unclear. This study aimed to investigate the potential association of anthropometric and body composition parameters with sleep in young adults, considering the mediating role of sedentariness, physical activity, and diet. A total of 187 adults aged 18–25 (35.29% men) participated in the study. Body mass index (BMI), waist–hip ratio, and waist–height ratio were calculated, and a dual-energy X-ray absorptiometry scanner was used to assess body composition. Sedentary time and physical activity, as well as sleep duration and quality, were objectively and subjectively measured using accelerometry and the Pittsburgh Sleep Quality Index. An inverse association was found between BMI and total sleep time (β = −0.165, p = 0.029). Waist–hip ratio and lean mass index were also negatively associated with total sleep time (β = −0.222, p = 0.007, and β = −0.219, p = 0.004) and sleep efficiency (β = −0.174, p = 0.037, and β = −0.188, p = 0.013). Sedentary time moderated by sex explained the association of BMI with total sleep time such that a high BMI was related to higher sedentariness in men which, in turn, was significantly associated with shorter sleep duration. Sedentary time is, therefore, a link/risk factor mediating the association of high BMI with short sleep duration in healthy young men.
Strategies to Improve Participation of Older Adults in Cancer Research
Authors: Liu Jennifer , Gutierrez Eutiquio , Tiwari Abhay , Padam Simran , Li Daneng , Dale William , Pal Sumanta K. , Stewart Daphne , Subbiah Shanmugga , Bosserman Linda D. , Presant Cary , Phillips Tanyanika , Yap Kelly , Hill Addie , Bhatt Geetika , Yeon Christina , Cianfrocca Mary , Yuan Yuan , Mortimer Joanne , Sedrak Mina S.
Published: May 2020

Cancer is a disease associated with aging. As the US population ages, the number of older adults with cancer is projected to dramatically increase. Despite this, older adults remain vastly underrepresented in research that sets the standards for cancer treatments and, consequently, clinicians struggle with how to interpret data from clinical trials and apply them to older adults in practice. A combination of system, clinician, and patient barriers bar opportunities for trial participation for many older patients, and strategies are needed to address these barriers at multiple fronts, five of which are offered here. This review highlights the need to (1) broaden eligibility criteria, (2) measure relevant end points, (3) expand standard trial designs, (4) increase resources (e.g., institutional support, interdisciplinary care, and telehealth), and (5) develop targeted interventions (e.g., behavioral interventions to promote patient enrollment). Implementing these solutions requires a substantial investment in engaging and collaborating with community-based practices, where the majority of older patients with cancer receive their care. Multifaceted strategies are needed to ensure that older patients with cancer, across diverse healthcare settings, receive the highest-quality, evidence-based care.
Managing Bladder Cancer Care during the COVID-19 Pandemic Using a Team-Based Approach
Authors: Wang Tina , Liu Sariah , Joseph Thomas , Lyou Yung
Published: May 2020

The recent novel coronavirus, named coronavirus disease 2019 (COVID-19), has developed into an international pandemic affecting millions of individuals with hundreds of thousands of deaths worldwide. The highly infectious nature and widespread prevalence of this disease create a new set of obstacles for the bladder cancer community in both delivering and receiving care. In this manuscript, we address the unique issues regarding treatment prioritization for the patient with bladder cancer and how we at City of Hope have adjusted our clinical practices using a team-based approach that utilizes shared decision making with all stakeholders (physicians, patients, caregivers) to optimize outcomes during this difficult time. In addition to taking standard precautions for minimizing COVID-19 risk of exposure for those entering a healthcare facility (screening all personnel upon entry and donning facemasks at all times), we suggest the following three measures: (1) delay post-treatment surveillance visits until there is a decrease in local COVID-19 cases, (2) continue curative intent treatments for localized bladder cancer with COVID-19 precautions (i.e., choosing gemcitabine/cisplatin (GC) over dose-dense methotrexate, vinblastine, doxorubicin, cisplatin (ddMVAC) neoadjuvant chemotherapy), and (3) increase the off-treatment period between cycles of palliative systemic therapy in metastatic urothelial carcinoma patients.
Intracellular Water Content in Lean Mass as an Indicator of Muscle Quality in an Older Obese Population
Authors: Serra-Prat Mateu , Lorenzo Isabel , Papiol Mònica , Palomera Elisabet , Bartolomé Maria , Pleguezuelos Eulogio , Burdoy Emili
Published: May 2020

Background: In aged populations, muscle strength depends more on muscle quality than on muscle quantity, while all three are criteria for the diagnosis of sarcopenia. Intracellular water content (ICW) in lean mass (LM) has been proposed as an indicator of muscle quality related to muscle strength in older people. Objectives: To evaluate the relationship between the ICW/LM ratio, muscle strength and indicators of functional performance in obese older adults, and to assess the value of the ICW/LM ratio as an indicator of muscle quality. Methodology: Design: cross-sectional study. Population: persons aged 65–75 years with a body mass index of 30–39 kg/m2. ICW and LM were estimated by bioelectrical impedance. Hand grip, gait speed, unipedal stance test, timed up-and-go (TUG) test, Barthel score and frailty (Fried criteria) were assessed. Sarcopenia was established according to EWGSOP2 criteria. Results: Recruited were 305 subjects (66% women), mean age 68 years. The ICW/LM ratio correlated with the TUG test, gait speed and grip strength, and was also associated with sex, the unipedal stance test and frailty. Independently of age, sex and muscle mass, the ICW/LM ratio was related with gait speed, the TUG test and unipedal stance capacity. One person (0.3%) had sarcopenia defined as low muscle strength and low muscle mass, while 25 people (8.2%) had sarcopenia defined as low muscle strength and poor muscle quality (ICW/LM). With this last definition, sarcopenia was related to frailty, gait speed and the TUG test. Conclusions: ICW content in LM could be a useful muscle quality indicator for defining sarcopenia. However, more studies are required to confirm our findings for other populations.
Comparison of the Diagnostic Value of MRI and Whole Body 18F-FDG PET/CT in Diagnosis of Spondylodiscitis
Authors: Altini Corinna , Lavelli Valentina , Niccoli-Asabella Artor , Sardaro Angela , Branca Alessia , Santo Giulia , Ferrari Cristina , Rubini Giuseppe
Published: May 2020

Spondylodiscitis is a spine infection for which a diagnosis by a magnetic resonance imaging (MRI) is considered the most appropriate imaging technique. The aim of this study was to compare the role of an 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and an MRI in this field. For 56 patients with suspected spondylodiscitis for whom MRI and 18F-FDG PET/CT were performed, we retrospectively analyzed the results. Cohen’s κ was applied to evaluate the agreement between the two techniques in all patients and in subgroups with a different number of spinal districts analyzed by the MRI. Sensitivity, specificity, and accuracy were also evaluated. The agreements of the 18F-FDG PET/CT and MRI in the evaluation of the entire population, whole-spine MRI, and two-districts MRI were moderate (κ = 0.456, κ = 0.432, and κ = 0.429, respectively). In patients for whom one-district MRI was performed, 18F-FDG PET/CT and MRI were both positive and completely concordant (κ = 1). We also separately evaluated patients with suspected spondylodiscitis caused by Mycobacterium tuberculosis for whom the MRI and 18F-FDG PET/CT were always concordant excepting in 2 of the 18 (11%) patients. Sensitivity, specificity, and accuracy of the MRI and 18F-FDG PET/CT were 100%, 60%, 97%, and 92%, 100%, and 94%, respectively. Our results confirmed the 18F-FDG PET/CT diagnostic value in the diagnosis of spondylodiscitis is comparable to that of MRI for the entire spine evaluation. This could be considered a complementary technique or a valid alternative to MRI.
Obesity and Diabetes Mediated Chronic Inflammation: A Potential Biomarker in Alzheimer’s Disease
Authors: Khan Md Shahjalal Hossain , Hegde Vijay
Published: May 2020

Alzheimer’s disease (AD) is the sixth leading cause of death and is correlated with obesity, which is the second leading cause of preventable diseases in the United States. Obesity, diabetes, and AD share several common features, and inflammation emerges as the central link. High-calorie intake, elevated free fatty acids, and impaired endocrine function leads to insulin resistance and systemic inflammation. Systemic inflammation triggers neuro-inflammation, which eventually hinders the metabolic and regulatory function of the brain mitochondria leading to neuronal damage and subsequent AD-related cognitive decline. As an early event in the pathogenesis of AD, chronic inflammation could be considered as a potential biomarker in the treatment strategies for AD.
The Rush for Land and Agricultural Investment in Ethiopia: What We Know and What We Are Missing
Authors: Cochrane Logan , Legault Danielle
Published: May 2020

More than a decade has passed since the triple crises of food, energy and finance in the period 2007–2008. Those events turned global investor interest to agriculture and its commodities and thereafter the leasing of tens of millions of hectares of land. This article reviews and synthesizes the available evidence regarding the agricultural investments that have taken place in Ethiopia since that time. We use a systematic review approach to identify literature from the Web of Science and complement that with additional literature found via Google Scholar. Qualitative and quantitative methods are used to analyze the available literature. In so doing, we raise questions of data quality, by analyzing the evidence base used by many studies (the Land Matrix database) and compare it with data we obtained from the Government of Ethiopia. We find that while the Land Matrix is the largest available database, it appears to present only a fraction of the reality. In critically assessing the literature, we identify areas that have been under-researched or are missing from the literature, namely assessments of gendered impacts, the role of diaspora and domestic investors, interdisciplinary approaches (e.g., integrating climate change, biodiversity, and water), and studies that move beyond technical assessment, such as looking at the impacts on traditional knowledge and socio-cultural systems.
Who Remains When Professional Farmers Give up? Some Insights on Hobby Farming in an Olive Groves-Oriented Terraced Mediterranean Area
Authors: Gennai-Schott Sabine , Sabbatini Tiziana , Rizzo Davide , Marraccini Elisa
Published: May 2020

Many land use systems in Mediterranean sloping areas risk abandonment because of nonprofitability, while their hydro-geological stability depends on an appropriate management. However, who are the land managers? What are their practices? Our research on the traditional olive groves of the Monte Pisano (Tuscany, Italy) reveals for the first time the quantitatively important role of hobby farmers as land managers in the area. We used a three-step-method: first, a database was constructed using several data sources to identify and map the population of olive growers; then, 35 semi-structured interviews were conducted, and finally, the data were analyzed to highlight the contribution of olive growers to the land management, along with their motivations and constraints. Our results found that hobby farmers constitute about 90% of all land managers in the study area and manage more than half of the agricultural land. They are a very uneven group, and there are no clear categories detectable by analyzing sociodemographic factors, practices and farm characteristics. They are the “same but different”, not following any market rules, as they are not profit-oriented. Their farming practices are quite homogeneous and mainly in-line with professional farming practices of that area, oriented versus a minimum input management.
9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop-2-yne-1-yl]anthracene: Synthesis and G-quadruplex Selectivity
Authors: Ribaudo Giovanni , Ongaro Alberto , Oselladore Erika , Zagotto Giuseppe , Memo Maurizio , Gianoncelli Alessandra
Published: May 2020

G-quadruplex DNA is the target of several natural and synthetic small molecules with antiproliferative and antiviral activity. We here report the synthesis through Sonogashira reaction and A3 coupling of a disubstituted anthracene derivative, 9,10-bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop-2-yne-1-yl]anthracene. The binding of this compound to G-quadruplex and double stranded DNA sequences was evaluated using electrospray ionization mass spectrometry (ESI-MS), demonstrating selectivity for the first structure. The interaction pattern of the ligand with G-quadruplex was investigated by molecular docking and stacking was found to be the preferred binding mode.
Thermoplastic Disks Used for Commercial Orthodontic Aligners: Complete Physicochemical and Mechanical Characterization
Authors: Daniele Valeria , Macera Ludovico , Taglieri Giuliana , Di Giambattista Alessandra , Spagnoli Giuseppe , Massaria Alessandra , Messori Massimo , Quagliarini Enrico , Chiappini Gianluca , Campanella Vincenzo , Mummolo Stefano , Marchetti Enrico , Marzo Giuseppe , Quinzi Vincenzo
Published: May 2020

Invisible orthodontic aligners (IOAs) have been introduced in the orthodontic field as an innovative alternative for fixed brackets, in relation to their ability to be easily inserted/removed from the oral cavity without affecting the chewing ability and the aesthetic of the patients. The paper provides a complete physicochemical and mechanical characterization of thermoplastic materials in the form of disks used for commercial IOAs. A wide palette of specific techniques is considered, from tensile tests and dynamic-mechanical analysis, to X-Ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transformation infrared spectroscopy (FTIR-ATR) analyses and water absorption tests. The disks are investigated before and after immersion into staining beverages (red wine, coffee, nicotine and artificial saliva), in terms of colour variations, transparency, and microscopic surface modifications by means of colorimetry, UV-VIS absorbance and scanning electron microscopy (SEM). Among all the samples, polyurethane (PU) exhibited the highest crystallinity and the highest values of mechanical and thermal resistance, while the poly(ethylene terephthalate)-glycol (PETG) samples presented better transparency and less ability to absorb water. Moreover, red wine and coffee give noticeable colour variations after 14 days of immersion, together with a slight reduction of transparency.