bluuebunny/crossref_metadata_2025 huggingface dataset:
In vitro characterization of self-emulsifying drug delivery system-based lipsticks loaded with ketoconazole
Authors: Prajapati Bhupendra G. , Paliwal Himanshu , Shah Parth A.
Published: April 2023

Background

Self-emulsifying system-based lipstick may prove to have the potential of enhancing moisturizing characteristics and delivering hydrophobic drug antifungal drugs for the management of lip fungal infection, especially candidiasis. In this study, the self-emulsifying drug delivery system (SEDDs) of ketoconazole was obtained using IPM (Oil), Tween 80 (surfactant), and PEG 400 (co-surfactant). The medicinal lipstick was developed from the SEDDs, and the concentration of waxes (beeswax and carnauba wax) and cow ghee (penetration enhancer) was optimized using a Box–Behnken design. The lipstick formulations were assessed based on physicochemical features, such as pH, spreadability, softening point, breaking point, content uniformity, and in vitro drug permeation. Furthermore, the optimal lipstick formulation was tested for stability and antifungal activity.

Results

The optimized formulation showed exceptional results in physicochemical analysis and ~ 87% release of the drug in 12 h. The formulations displayed adequate stability for 4 weeks at various temperature conditions such as room temperature, 40 °C, and 45 °C. The zone of inhibition produced by lipstick formulation was significantly higher as compared to the reference standard (ketoconazole in ethanol) which shows high antifungal activity.

Conclusion

It was concluded from the outcomes that SEDDs-based lipstick formulation showed a lot of promise as a topical antifungal treatment option for Candidiasis.

Graphical abstract
Gastro-esophageal and respiratory morbidity in children after esophageal atresia repair: a 23-year review from a single tertiary institution in Asia
Authors: Chiang Jayne , Yap Te-Lu , Arif Shaista , Choo Candy S. C. , Pugalenthi A. K. , Thomas Biju , Jacobsen Anette S. , Ong Lin Yin
Published: April 2023

Background

Improved survival of neonates with esophageal atresia with/without tracheoesophageal fistula (EA/TEF) has resulted in increased prevalence of gastro-esophageal and respiratory-related morbidities. However, long-term outcome data on these patients remains limited, making it difficult to substantiate any guidelines on their chronic care. The purpose of our study is to report on their post-operative outcomes especially the long-term gastro-esophageal and respiratory morbidities.

Methods

This was a retrospective review of 65 patients (39 males, 26 females) who underwent EA/TEF repair from 1996 to 2019 at a single tertiary institution. Follow up data pertaining to clinical characteristics, operative management and long-term gastro-esophageal and respiratory morbidities was analyzed.

Results

Fifty-seven patients (87.7%) had Gross Type-C anatomy, followed by 5(7.7%) patients with Type-A, 1(1.5%) with Type-B and 1 with Type-D. One patient had a late diagnosis of H-type fistula (Type-E). Thirteen (20%) patients had long-gap EA.

Median age at first surgery was day 1 (IQR 1–2) of life. All patients underwent bronchoscopy at their index surgery. All 52 non-long gap EA (LGEA) patients underwent primary anastomosis, while most (76.9%) LGEA patients underwent staged repair. Post-operatively, 4(6.2%) developed anastomotic leak which resolved with conservative management. Three (4.6%) had recurrent TEF, 2 underwent re-do ligation. Twenty (30.8%) patients developed anastomotic strictures, with 15 requiring serial dilatation.

Long-term burden of gastro-esophageal and respiratory morbidity was high (63.1%; 64.6% respectively). The majority (n = 39,60%) of patients required active follow-up for a median duration of 5 years (IQR 1.5–10 years). Predominant conditions were gastroesophageal reflux disease (n = 28, 43.1%), dysphagia (n = 20, 30.8%), recurrent respiratory infections (n = 23, 35.3%), chronic cough (n = 19, 29.2%), and pneumonia (n = 19, 29.2%). Tracheomalacia was diagnosed in 22(33.8%), 2 of whom required tracheostomy for severe disease. Overall mortality rate was 10.8% (n = 7): 5 demised due to chronic respiratory failure, while 2 demised intra-operatively during the index surgery.

Conclusion

Despite successful surgical repair for EA/TEF, our data demonstrated significant morbidities among EA/TEF survivors, thus highlighting the importance of long-term multi-disciplinary care with collaboration between respiratory, gastroenterology, and otolaryngology specialists.

Level of evidence

Prognostic, Level IV.
How to develop semiotics: Paul Cobley
Authors: Kull Kalevi , Velmezova Ekaterina
Published: April 2023

How to develop semiotics: Paul Cobley
Metabolic accompaniment of quantitative-qualitative blood pressure clusters in patients of Truskavets’ spa
Authors: Kozyavkina Nataliya , Vovchyna Yuliya , Voronych-Semchenko Nataliya , Zukow Walery , Popovych Igor
Published: April 2023

Background. Earlier we studied the neural and endocrine accompaniments of quantitative-qualitative blood pressure (BP) clusters of profile patients of Truskavets’ spa. The purpose of this study is to clarify the metabolic accompaniment in the same contingent. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP (tonometer “Omron M4-I”, Netherlands). The plasma levels of lipids, glucose, nitrogenous metabolites and electrolytes as well as urinary excretion of last two were determined. In addition, electrokinetics and cholecystokinetics indexes were determined. Results. The forward stepwise program identified 21 parameters as characteristic of quantitative-qualitative blood pressure clusters. In addition to BP parameters by default, the most informative among them are sodium and uric acid daily excretion as well as plasma phosphate and magnesium, whose levels are maximal in patients with hypertension, while minimal in patients with low norm BP, on the one hand, and electrokinetics index, the level of which are polar, on the other hand. The accuracy of patient classification is 97,7%. Conclusion. The quantitative-qualitative blood pressure clusters have a characteristic metabolic accompaniment.
Edge effects on ant diversity and functional composition in a forest fragment in the Central Amazon
Authors: Santos Talitha Ferreira dos , Mesquita Vanessa Pontes , Araújo Juliana de Souza , Baccaro Fabricio Beggiato
Published: April 2023

The process of human-induced forest fragmentation increases the degree of isolation and causes biodiversity loss. Abrupt changes occur mainly near the edge of the fragment, where the average temperature is relatively higher and the humidity is lower. However, some natural environmental characteristics, such as higher air moisture in riparian areas, may buffer or minimize the edge effects. Here, we studied how the edge effect may affect ant species diversity and functional composition on valleys dissected by small streams (mesic areas). We categorized ant assemblages into the functional groups based on foraging, nesting habits, natural history information, and phylogeny. Ants were sampled using pitfalls and the Winkler extractor in ten riparian plots in a fragment of the Central Amazon. We individually fit the ant species richness, occurrence, and composition against two edge measures: forest edge distance and road-building distance. We recorded 99 species/morphospecies. Forest edge distance and road-building distance did not influence the occurrence and number of ant species per plot but were related to ant species composition. Moreover, there was not a clear pattern between functional groups distribution, except by leaf-cutters and generalist omnivorous species. Our results suggest a limited effect of forest edge distance and road-building distance on ant diversity
Recognition and Defensive Behavior of Nannotrigona testaceicornis Workers (Lepeletier, 1836) (Hymenoptera, Apidae) in Intra and Inter-colonial Bioassays
Authors: Correia Catarina Silva , Pérez-Maluf Raquel , Costa Marco Antonio
Published: April 2023

Nannotrigona testaceicornis (Lepeletier, 1836) is a stingless bee with wide distribution in the Brazilian territory. Despite its importance in meliponiculture and pollination, there are still few behavioral studies related to the species. The aim of this work was to characterize the recognition and defense behaviors in intraspecific bioassays carried out in N. testaceicornis colonies. Intra and inter-colonial bioassays were carried out with six colonies from different locations. The number of occurrences of each behavioral act, latency measures, and duration of confrontations were quantified. An ethogram with eight behavioral acts and two categories was elaborated. The acceptance rate was significantly higher in intra-colonial confrontations and the rejection rate was higher in inter-colonial confrontations. The rejection process was significantly higher than the acceptance process, which may be related to the specific behavioral repertoire of each process. Results indicate that the presence of an intraspecific intruder triggers an aggressive response from guards positioned in the colony access tube.
Urate-lowering therapy and kidney function
Authors: Eliseev M. S.
Published: April 2023

Chronic hyperuricemia (CH) and gout are independent risk factors for decreased kidney function. In the last decade, evidence was accumulating that urate-lowering therapy may be an effective method of slowing down the progression of CH and gout-mediated renal failure. At the same time, the main goal of gout therapy is the complete resorption of urate crystals, which leads to resolution of the disease, but is impossible without longterm use of urate-lowering drugs. However, the treatment of gout in the presence of chronic kidney disease is much more complex and requires consideration of the potential impact of drugs on targeted serum uric acid level and on renal function, as well as predicting the risk of adverse events. The article presents practical recommendations regarding the use of urate-lowering drugs in gout patients with chronic kidney disease.
Pharmaconutraceutical Chondroguard®TRIO – a new ideology for the prevention of musculoskeletal diseases and nutritional support for patients with osteoarthritis and nonspecific back pain: an assessment of clinical options. Resolution of the First Multidisciplinary Bilateral Russia – Uzbekistan Expert Council
Authors: Editorial Article
Published: April 2023

On April 1, 2023, experts presented a resolution of the First Multidisciplinary Bilateral Russia–Uzbekistan Expert Council, dedicated to innovations in the prediction and personalized prevention of degenerative-dystrophic diseases of the joints and spine, and the possibilities of using the new pharmaconutraceutical Chondroguard®TRIO, the components of which (chondroitin sulfate, glucosamine sulfate, undenatured collagen type II – NK-II type) can be attributed to active compounds that modify the course of the disease (Disease-modifying osteoarthritis drugs, DMOADs) through structure-modifying and immune-mediated mechanisms of action. The evidence base for the efficacy and safety of the use of the main components of the new pharmaconutraceutical Chondroguard®TRIO (chondroitin sulfate, glucosamine sulfate, type NK-II) for the prevention and adjunctive therapy of osteoarthritis and nonspecific back pain is presented in the clinical recommendations of foreign specialized associations: Osteoarthritis Research Society International (OARSI), European Alliance of Associations for Rheumatology (EULAR), European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), American College of Rheumatology (ACR), Russian Clinical Guidelines of the Russian Ministry of Health, as well as in numerous interventional and observational clinical studies.
Rhupus – a combination of systemic lupus erythematosus and rheumatoid arthritis as a separate disease phenotype (a clinical case)
Authors: Nikishina N. Yu. , Aseeva E. A. , Mesnyankina A. A. , Soloviev S. K.
Published: April 2023

Rhupus is a rare combination of systemic lupus erythematosus (SLE) and rheumatoid arthritis, one of the characteristic features of which is the development of erosive polyarthritis on the background of the main immunological signs of SLE. The article presents a clinical observation in which, along with the typical immunological picture of SLE, the patient was diagnosed with erosive polyarthritis with “swan neck” type deformities of the hand joints, which required administration of anti-B-cell therapy.
Differential diagnosis of a local form of granulomatosis with polyangiitis: ocular and ear involvement (part 2)
Authors: Egorova O. N. , Kharlamova E. N. , Tarasova G. M.
Published: April 2023

Granulomatosis with polyangiitis (GPA) is a primary vasculitis associated with antineutrophil cytoplasmic antibodies, characterized by necrotizing vasculitis with predominant involvement of small vessels of various localization and necrotizing granulomatous inflammation with multiple clinical manifestations. GPA remains one of the most severe and prognostically unfavorable systemic vasculitis. The second part of the article presents data on the differential diagnosis of the onset of the disease with the ocular and ear involvement, which requires an interdisciplinary approach and interaction between doctors of different specialties. In the refractory course of the local form of GPA, immunosuppressive therapy, including glucocorticoids and rituximab or cyclophosphamide, is advisable.
Treatment of resistant forms of systemic lupus erythematosus with a type I interferon inhibitor in the early access program
Authors: Leineman I. A. , Samigullina R. R. , Shostak M. S. , Mazurov V. I.
Published: April 2023

The article presents the results of treatment of patients with systemic lupus erythematosus (SLE), who, due to resistance to traditional regimens, for the first time in the Russian Federation were included in the early access program of the type I interferon inhibitor – anifrolumab. Clinical data and results of instrumental examinations of a patient with SLE on the background of 6-month therapy are presented.
Lung involvement in rheumatoid arthritis
Authors: Popova E. N. , Mitkina M. I. , Ponomareva L. A. , Ponomarev A. В. , Tchinova A. A. , Moiseev S. N.
Published: April 2023

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease of unknown etiology, characterized not only by joint destruction, but also by visceral organ involvement. Interstitial lung disease is considered the most common and serious pulmonary complication of RA, with a prevalence of about 50% according to most studies. As a rule, involvement of the lungs occurs several years after the onset of RA. The article presents a description of a clinical case of the development of respiratory disorders (severe dyspnea) as early as a month after RA onset.
Suppression of acute bone marrow edema (osteitis) in the sacroiliac joints with long-term use of non-steroidal anti-inflammatory drugs in patients with axial spondyloarthritis
Authors: Erdes Sh. F. , Starkova A. S.
Published: April 2023

Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) is a concern for both doctors and patients. However, in axial spondyloarthritis (axSpA), NSAIDs are used not only as a symptomatic therapy, but also to prevent the progression of the disease. Therefore, in active axSpA, NSAIDs are recommended to be administered for a much longer period of time than it is indicated in the instructions for use of the drug. The article presents two clinical cases of long-term use of etoricoxib in active axSpA. In both cases, clinical efficacy and resolution of active osteitis in the sacroiliac joints, good tolerability of treatment were noted.
Alflutop Russian longitudinal multicentre observational study: preliminary results (message 1)
Authors: Lila A. M. , Alekseeva L. I. , Taskina E. A. , Kashevarova N. G.
Published: April 2023

Evaluation of the effect of new drugs should be carried out in randomized controlled trials (RCTs), and observational studies (OSs) are carried out to confirm and refine the results obtained in RCTs, for example, to study the effectiveness of drugs in large groups of patients who were not included in RCTs or had comorbidities or older age.

Objective: to evaluate the effectiveness of Alflutop (AF) via OS of patients with osteoarthritis (OA) of the knee and/or hip joints and/or low back pain (LBP) with or without comorbid diseases.

Material and methods. A multicenter prospective cohort OS was conducted in 163 clinical centers in 58 cities of the Russian Federation and included 22,525 patients with OA and LBP who received AF as a part of a planned treatment prescribed by a doctor, or self-prescribed and purchased in a pharmacy. Pain, satisfaction with therapy, health assessment, need for non-steroidal anti-inflammatory drugs (NSAIDs), and quality of life were recorded using the EQ-5D questionnaire.

Results and discussion. After one treatment course with AF, improvement was detected in 98% of cases, there was a rapid positive trend with a significant decrease in pain, the median time to clinical effect was 8 [5; 10] days. Assessment of general health status and satisfaction with therapy improved significantly. In 94.5% of patients, the daily requirement for NSAIDs decreased.

Conclusion. The first results from the OS confirm the symptomatic effect of AF.
Three-dimensional CFD-solid mechanics analysis of the hydrogen internal combustion engine piston subjected to thermomechanical loads
Authors: Al-Baghdadi Maher A.R. Sadiq , Ahmed Sahib Shihab , Ghyadh Nabeel Abdulhadi
Published: April 2023

Fueling internal combustion engines with hydrogen is one of the most recommended alternative fuels today in order to combat the energy crisis, pollution problems, and climate change. Despite all the advantages of hydrogen fuel, it produces a higher combustion temperature than gasoline. In an internal combustion engine, the piston is among the numerous complex and highly loaded components. Piston surfaces are directly affected by combustion flames, making them critical components of engines. To examine the stress distribution and specify the critical fracture zones in the piston for hydrogen fuel engines, a three-dimensional CFD-solid-mechanics model of the internal combustion engine piston subjected to real thermomechanical loads was analyzed numerically to investigate the distribution of the temperature on the piston body, the interrelated thermomechanical deformations map, and the pattern of the stresses when fueling the engine with hydrogen fuel. With the aid of multiphysics COMSOL software, the CFD-solid-mechanics equations were solved with high accuracy. Despite the increase in pressure on the piston and its temperature when the engine is running on hydrogen fuel, the results show that the hydrogen fuel engine piston can withstand, safely, the thermomechanical loads. In comparison to gasoline fuel, hydrogen fuel caused a deformation of 0.34 mm, an increase of 17%. This deformation is within safe limits, with an average clearance of 0.867 mm between the cylinder liner and piston.
Az antropometriai paraméterek szerepe a cadaveren végzett percutan tracheostomás módszerekben
Authors: Bódis Fruzsina , Orosz Gábor , Szabó Marcell , Molnár Viktória , Tóth T. József , Élő László Gergely , Tamás László , Élő Gábor
Published: April 2023

Bevezetés és célkitűzés: A tartós gépi lélegeztetésre szoruló
betegeknél tracheostoma képzése javasolt, mely számos sebészi és percutan
módszerrel történhet. Vizsgálatunk során három különböző percutan dilatatiós
tracheostomás technikát alkalmaztunk. Célunk volt a megfelelő magasságban
behelyezett légcsőkanüllel összefüggő antropometriai paraméterek azonosítása.
Anyag és módszerek: Randomizált, kontrollált obszervációs
cadavervizsgálatunk során 118 esetet vizsgáltunk. A tracheostomás technikák
közül a Griggs-technikát (n = 37), az Élő szerint módosított Griggs-technikát (n
= 45) és a Ciaglia szerinti Blue Rhino folyamatos tágítást (n = 36) alkalmaztuk.
Megmértük a cadaverek nyakkörfogatát, jugulomentalis távolságát és
felkarkörfogatát. Megvizsgáltuk ezek összefüggését a tracheostomás kanül
helyzetével. Eredmények: A felkarkörfogat és a nem megfelelő
magasságban (a 4. tracheaporc alatt) behelyezett kanülpozíció között találtunk
szignifikáns összefüggést (p = 0,0287). Ideális vágópontnak a 30 cm-es
felkarkörfogatot határoztuk meg (szenzitivitás: 63,63%, specificitás: 60,22%).
Következtetés: Percutan tracheostoma tervezésekor fontos az
antropometriai paraméterek mérése. 30 cm vagy annál nagyobb felkarkörfogat
esetén egyéb vizsgálómódszer és/vagy fül-orr-gégészeti konzultáció javasolt. Orv
Hetil. 2023; 164(16): 630–635.
Az urachuscarcinoma aktuális diagnosztikai és kezelési lehetőségei
Authors: Módos Orsolya , Váradi Melinda , Dér Bálint , Keszthelyi Attila , Szűcs Miklós , Reis Henning , Nyirády Péter , Szarvas Tibor
Published: April 2023

Az urachuscarcinoma ritka malignus betegség, mely bár nem tekinthető szoros
értelemben vett urológiai daganatnak, leggyakoribb tünete, a vérvizelés miatt
általában urológiai intézményekben fedezik fel. Diagnosztikájával és kezelésével
kapcsolatos adataink elsősorban esettanulmányokból származnak, prospektív
klinikai vizsgálatok eredményei nem állnak rendelkezésre. Ebből adódóan szakmai
irányelvek sem fogalmazódtak meg, ezek hiányában pedig az urachuscarcinomás
betegek kezelése komoly kihívást jelent, és többnyire változatos egyéni
döntéseken alapul. A jelen áttekintő közleményben összefoglaljuk a betegség
előfordulásával, diagnosztikájával, prognózisával, valamint lokális és
szisztémás kezelésével kapcsolatos aktuális ismereteket, és ezek alapján
próbálunk meg a klinikai gyakorlatban is használható következtetéseket levonni.
Végül kiemelünk néhány újabb kezelési stratégiát, mely a jövőben potenciálisan
javíthatja az urachuscarcinomás betegek túlélését és életminőségét. Orv Hetil.
2023; 164(16): 602–609.
Pretreatment of kaempferol-3-O-rutinoside protects H9c2 cells against LPS-induced inflammation through the AMPK/SIRT1 pathway
Authors: Ma Yao-yao , Zhao Xiao-ni , Zhou Lan , Li Sheng-nan , Bai Juan , Shi Ling-li , Hua Fang , Zhou Peng
Published: April 2023

Kaempferol-3-O-rutinoside (KR) is a flavonoid glycoside derived from traditional Chinese medicine, plants, and tea, and has good myocardial protection. This study focuses on the mechanism of myocardial protection with KR and whether myocardial protection can be achieved by activating the adenosine monophosphate-activated protein kinase–silent mating-type information regulation 2 homolog 1 (sirtuin) (AMPK/SIRT1) signal pathway. Molecular docking technique was used to predict the binding affinity of KR to AMPK. The inflammatory injury model of H9c2 cells was established by lipopolysaccharide (LPS) induction. H9c2 cell proliferation was detected by cell counting kit -8 assay. The apoptosis rate was measured by flow cytometry. Levels of interlukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were determined by enzyme-linked-immunosorbent serologic assay. AMPK and SIRT1 expression levels were quantified through reverse transcription-polymerase chain reaction and Western blotting assay. Results indicated that KR has a certain binding affinity with AMPK. KR could increase the growth of H9c2 inhibited by LPS, reduce apoptosis rate, and reverse the elevated levels of IL-1β, IL-6, and TNF-α. Furthermore, KR could suppress the expression levels of AMPK and SIRT1, and AMPK-specific inhibitor (Compound C) could significantly counteract the activation of KR, indicating that its anti-inflammatory effect is achieved by regulating the AMPK/SIRT1 signaling pathway.
Configurar mundos monstruosos: especulaciones desde Donna Haraway para el pensamiento y la educación ambiental
Authors: Klier Gabriela , Folguera Guillermo
Published: April 2023

La crisis ambiental es un punto de quiebre que nos enfrenta con las consecuencias de los mundos extractivistas, capitalistas y modernos, a la vez que reclama pensamientos y educaciones que posibiliten otras realidades, en las que la cohabitación con diferentes formas de vida, la sustentabilidad y la justicia socioambiental sean horizontes de construcción. Este artículo busca presentar ciertas ideas de la filosofía de Donna Haraway para configurar otros mundos habitables, y que pueden ser consideradas en diferentes ámbitos de la educación y el pensamiento ambiental. A partir de la obra de Haraway, y en diálogo con diferentes autores, se propone indagar en cinco ejes: a. el pensamiento tentacular, para entretejer cuerpos, ideas y territorios diversos; b. la generación de parentescos y la pregunta por las relaciones con diferentes seres vivos y entornos; c. lo monstruoso como potencia desclasificatoria y generadora de nuevas comprensiones ambientales; d. la necesidad de nuevas configuraciones sobre la(s) Naturaleza(s) como construcciones colectivas, y e. la potencia de las artes en el pensamiento ambiental, como fuerza motora para la imaginación de mundos posibles y para la apertura de nuevas preguntas y afectos. Nuestras conclusiones apuntan a la necesidad de tender puentes entre esta autora y el pensamiento y la educación ambiental en Latinoamérica, así como habilitar ciertas preguntas brújula, preguntas vivas para transitar los caminos de un planeta herido. ¿Con qué pensamientos pensamos? ¿Qué relaciones armamos con otros seres? ¿Cómo devenir inapropiables, reivindicar lo monstruoso? ¿Qué relatos contamos y qué relatos nos cuentan? ¿Cómo afectar prácticas y saberes ambientales?
When employees’ become change agents: Unfolding theme chanism promoting the change supportive behavior
Authors:   University Utara Malaysia, Sintok, Malaysia, Mehboob Farhan , Raheela Haque Raheela Haque ,   Sukkur IBA University, Sukkur, Pakistan, Othman Noraini ,   University Utara Malaysia, Sintok, Malaysia
Published: April 2023

Purpose. Organizational change does not always have just negative repercussions but alsohave positive implications. Drawing on job demands-resources (JD-R) model, this study aims to examinethe effects of empowering leadership on employees’ change supportive behavior through job crafting behavior, a relationship that is moderated by hope. Study design. Data was collected from bank staffof one of the leading banks in Pakistan that is going through major techno-structural change by crosssectional means. We distributed 342 questionnaires and collected 211 in return; the final sample size was 203. In corresponding sample, 84% of the respondents were male; about 47% of them found inage between 26–35 years old, while 34% had experience of 5–10 years comprising the highest bracket.The questionnaire comprised of multi-dimensional facets of empowering leadership and job crafting, and one-dimensional aspect of hope and change supportive behavior. PLS-SEM approach was opted tomake inferences and estimations of the proposed model. Findings. Consistent with our expectations, the result shows that empowering leadership positively predicts employees’ change supportive behavior. Italso reveals that the relationship between empowering leadership and change supportive behavior is mediated by job crafting. Furthermore, hope moderates the relationship between empowering leadershipand job crafting. Value of the results. The study offers fresh theoretical, empirical, and practical insights into the existing body of change literature. It contributes to the research on organizational change by addressing multiple perspectives in a single study by simultaneously examining the person and context factors and activation phenomenon to unfold one’s behavioral support for change.
Cross-sectional study on electroencephalographic oscillations when achieving heart coherence in medical students at the Technological University of Pereira v1
Authors: David Morales Rudas Juan
Published: April 2023

Heart coherence is a technique that consists of synchronizing breathing with heart rate, which produces physiological and psychological benefits. The aim of this cross-sectional study is to analyze the characteristics of electroencephalographic oscillations during the implementation of the cardiac coherence strategy in medical students. The target population are the active students of the medical program of the Universidad Tecnológica de Pereira in 2023, aged between 18 and 30 years. A sample of 20 students will be selected by a non-probabilistic convenience sampling. The variables of frontal alpha asymmetry (FAA), relative theta power (RTP), relative beta power (RBP), frontal beta asymmetry (FBA), delta coherence (DC) and theta/beta ratio (TBR) will be measured before and after the intervention. Matlab software and different toolboxes will be used for processing the information collected by a heart rate variability (HRV) sensor and skin electrodes. It is expected that cardiac coherence will produce significant changes in electroencephalographic variables, which could reflect a state of greater balance and harmony between the nervous and cardiovascular systems. These results could contribute to research in the field of neuroscience, which may lead to advances in the development of new techniques for the management of various psychiatric disorders.
Digitization of data from published plots v1.0 v1
Authors: Nilsonne Gustav
Published: April 2023

Purpose This is a protocol for digitizing data that have been published in diagrams available as image files (such as .img or .png). The typical use-case is to extract data from published scientific papers for secondary analyses or for meta-analysis.
DNA extraction and purification from dermatophytes using the Qiagen DNEasy™ UltraClean Microbial kit (Qiagen, 12224-50) v2
Authors: El Moussaoui Khalid
Published: April 2023

This protocol describes the steps to extract and purify genomic DNA from dermatophytes (and more specifically from dermatophytes of the genus Trichophyton). The extracted DNA is then quantified by spectrophotometry. The yields obtained by this method are between 5 ng/μL and 30 ng/μL.The genomic DNA obtained by following this procotole is little/not fragmented and therefore compatible with high-throughput genome sequencing applications on the Illumina platform. We used this protocol to extract the sequenced fungal DNA as part of BioProject PRJNA956242.
Modern approaches in the treatment of oncological pain: surgical treatment
Authors: Yarikov A. V. , Kuznetsov S. F. , Dubskikh A. O. , Fraerman A. P. , Perlmutter O. A. , Kabardaev R. M. , Khinovker V. V.
Published: April 2023

Based on the analysis of modern literature, surgical approaches to the treatment  of chronic pain syndrome in cancer patients are presented. The definition and classification of chronic pain syndrome is given, its pathophysiology is described. The frequency of occurrence in the population and its dependence on the stage and localization of malignant neoplasm is shown. For practical use, an algorithm for the diagnosis of chronic pain syndrome and the basic principles of its therapy are presented.  As the 4th step of the World Health Organization pain relief ladder, surgical methods for the treatment of chronic pain syndrome are separately considered. Three main types of surgical interventions (neuromodulating, neurodestructive and anatomical) are described, indications and contraindications to their use are indicated.
Regional lymphadenectomy in the treatment of patients with melanoma skin with metastases in the sentinel lymph nodes
Authors: Abramova O. E. , Kudryavtsev D. V. , Kurilchik A. A. , Ivanov S. A.
Published: April 2023

Regional recurrences are one of the most common first manifestations of progression of clinically localized cutaneous melanoma. They are caused by subclinical metastases in the lymph nodes. Biopsy of the sentinel lymph nodes is the most effective method of detection of hidden regional metastases. It allows to appropriately increase the volume of surgical treatment  prior to dissection of the affected lymph collector and perform adjuvant therapy with the most effective drugs. This, in its turn, allows for significant improvement of regional and systemic control of the disease and long-term treatment outcomes.

Data obtained in several randomized trials on the effectiveness of lymph node dissection in patients  with sentinel lymph node metastasis showed that this procedure significantly improves regional control of the disease but does not affect long-term treatment outcomes. Additionally, some studies showed that assignment of responsibility for regional control to adjuvant therapy does not meet the expectations. Therefore, the most effective method of regional control of cutaneous melanoma is surgery. All of these studies show that it is necessary to develop criteria for identification of patients with high risk of metastases in the non-sentinel lymph nodes who require lymph node dissection for regional disease control and creation of the best conditions for adjuvant systemic therapy. This requires identification of predictors of multiple involvement of regional lymph nodes justifying indications for radical lymph node dissection. Studies in this area are being performed but their results are ambiguous and sometimes contradictory.

Aim. To evaluate the effectiveness of lymph node biopsy and radical lymph node dissection in patients with cutaneous melanoma and subclinical involvement of the sentinel lymph node.
Long-term results of isolated limb perfusion with hyperthermia in patients with limb melanoma
Authors: Petrochenko N. S. , Kharatishvili T. K. , Valiev A. K. , Buydenok Yu. V. , Kaspshik S. M. , Gribkova E. I. , Salkov A. G.
Published: April 2023

Introduction. In patients with local recurrences of melanoma or with transit metastases of this tumor located distal to the axilla and inguinal region, the use of isolated regional limb perfusion is considered as one of the effective treatment options.

Aim. To evaluate the long-term results of treatment extremities melanoma using the method of isolated regional perfusion of the extremities.

Materials and methods. An analysis of the treatment and observation results of 72 patients (12 men and 60 women) with melanoma of the extremities was carried out, the median age was 56.7 years (from 25 to 78 years). All patients underwent isolated regional perfusion with hyperthermia using melphalan at doses of 10 mg/l volume for the lower limb and 13 mg/l volume for the upper limb. Patient survival for 5 years, the incidence of relapses and metastases of melanoma, as well as the frequency of limb amputation were assessed.

Results. The rate of complete response to treatment was 13.9 %, in the vast majority of cases there was a partial regression – in 72.2 % of cases. There was no response to treatment in only 13.9 % of patients.

Recurrence of transit metastases within 5 years developed in 52 (72.2 %) patients.  Amputation was performed only in 11.1 % of cases. The 1-year survival rate was 91.7 %, the 5-year survival rate for melanoma patients who underwent isolated regional perfusion was 55.6 %.

Сonclusion. Isolated regional perfusion under conditions of hyperthermia with melphalan is an effective and safe method of treatment  in terms of long-term results of melanoma treatment,  providing a 5-year patient  survival rate of 55.6 %, a low rate of amputations and metastasis.
Safety and effectiveness of continuous denosumab for unresectable or advanced giant cell tumor
Authors: Tararykova A. A. , Fedenko A. A. , Musaev E. R. , Valiev A. K. , Borzov K. A. , Sushentсov E. A. , Sofronov D. I. , Sokolovskii A. V. , Dzampaev K. A.
Published: April 2023

Introduction. Giant cell tumor of bone is a relatively rare, locally aggressive osteolytic skeletal neoplasm with uncertain behavior: recurrence rates up to 70 % and distant metastases occur 2–6 % of cases. Nowadays denosumab is the choice of therapy for patients  with unresectable  or advanced disease. However,  the efficiency,  duration or administration and most of all safety of continuous denosumab are not established.

Materials and methods.  Fourty advanced or unresectable giant cell tumor cases were observed from 2005 till 2020 in N.N. Blokhin National Medical Research Center of Oncology. The average age of pts was 33,6 ± 13,1 years (18–64), and the women and men ratio was about 2,1 : 1. The most commonly affected sites were long bones of the lower extremities (22,5 %), sacrum (22,5 %), long bones of the upper extremities (17,5 %), spine (17,5 %), pelvis (10 %) and others. 70 % of cases were anatomically compounded due to tumor localization and 27,5 % of cases were primary disease. 37,5 % of cases were with pulmonary metastases. Patients underwent computed tomography / magnetic resonance imaging every 3 months during the first three years and then once every six months. Patient received subcutaneous denosumab 120 mg every 4 weeks with a loading dose of 120 mg subcutaneous on study days 8 and 15. After 2 years monthly therapy and confirmed stabilization  effect patient  then  received maintenance  therapy: once in three  months injection. All patients received daily calcium and vitamin D supplement.

Results. Median follow-up was 52,8 ± 41,3 months (3–219 months). The average denosumab injections were 25 ± 16 (4–85). Clinical and radiographically stabilization of the effect occurred on average at 12 ± 8 (4–32) injections. Hypocalcemia was registered in one case (2.5 %). There was significant improvement of Karnofsky scale, Visual analogue scale (VAS) and Watkins scale (p <0.001). 5-year progression-free survival for was 70.1 % (95 % confidence interval 55.7–88.0), the median was not reached. Progression of disease was observed only in subgroup with violations in denosumab administration or its cancellation (32,5 %). 3-year progression-free survival in subgroup with violations in denosumab administration or its cancellation was 10 % (95 % confidence interval 15.5–64.1). In subgroup with continuous denosumab and once in three months injection after 2 years monthly therapy there was no signs of progression.

Conclusions. In this study we showed evidence of safety and effectiveness of continuous denosumab for unresectable or advanced giant cell tumor even with once in three months injection therapy. Denosumab for advanced giant cell tumor of bone became a choice of treatment, but we need further investigation for observation long term denosumab effectiveness and complications.
Clinical case of treatment of secondary chondrosarcoma developed due to Ollier disease
Authors: Zamilov M. M. , Menshikov K. V. , Musin Sh. I. , Sultanbayev A. V. , Sharifgaliev I. A. , Osokin S. V. , Chalov V. S.
Published: April 2023

Ollier disease is a rare non-hereditary disorder of the bone tissue characterized by development of multiple benign bone tumors – enchondromas. One of the dangerous complications of this pathology is tumor transition into chondrosarcoma. Currently, there are no drug therapies for Ollier disease. Surgical treatment is performed in case of complications (chondrosarcoma, pathological fracture).

The article presents a clinical case of chondrosarcoma treatment  in a 42-year-old male with Ollier disease diagnosed when the patient was 8 years old. Since 2021, the patient noted intensive tumor growth on the right foot and left calf. In August of 2022, the patient sought medical help at the Republican Clinical Oncological Dispensary of the Bashkortostan Ministry of Health. Examination showed synchronous malignant transformation of enchondromas of the right foot and left calf confirmed by histological exam. Due to tumor advancement, surgical treatment  was performed. Other enchondroma lesions are being watched.
A process-sociology analysis of religious practices and Japanese martial arts
Authors: Sánchez García Raúl
Published: April 2023

This paper uses primary and secondary sources to provide a process-sociological analysis of the relationship between religious practices and Japanese martial arts. It problematises the taken for granted role of Zen Buddhism as the sole influence on the development of Japanese martial arts. Such essential connection is inaccurate and anachronistic. Religious and martial practices developed as part of processes of sociogenesis (state formation) and psychogenesis (habitus) during three different key stages: (1) Medieval Japan (1185-1600): during this stage, warriors (bushi) progressively became the predominant rulers across the country, enforcing law by sheer force. Warriors seasoned in combat used esoteric practices (spells, magic rituals) as part of their psychological arsenal for warfare, as practical means of action. The cult of the Buddhist deity Marishiten held special interest for the bushi originating martial traditions (ryu). (2) Tokugawa shogunate (1600-1848): the pacification of the country by the central military court implied a more detached approach to martial arts by samurai. Within this milieu, the samurai acted as a retainer/bureaucrat whose main mission was to keep order in a stratified society and to serve his lord, something that Zen practices helped to incorporate in the samurai ethos. (3) Early Showa period (1926-1945): this stage featured a progressive militarisation of people and the instigation of a strong involvement towards the Japanese nation, considered as the main (symbolic) survival unit. Budo (martial arts) was connected to shinto (functioning as a ‘state religion’) and embodied the imperial bushido message. Zen provided a legitimation of violence for citizen-soldiers with a personality structure that presented self-doubts on killing someone and fear of being killed.
Understanding the Unending Learning Language Technique
Authors: Fadziso Takudzwa
Published: April 2023

Human beings learn different things from their experiences in life, beginning from when they were born to this planet and they keep improving as the day goes by. Though, machine learning techniques are becoming more useful in all areas of life, just like human beings. As such, humans instead learn many functions cumulatively while they are learning a single one. The goal of this research is to determine what motivates learners to learn. The data was qualitative. This research involves collecting data from libraries, reading, recording, and processing library collection materials without conducting any field research. This research presents reasons based on a literature review and on the researcher's thoughts about learning a second language. This supports discussions on factors influencing learners' language learning. The research found that there are four factors in the education process that influence language teaching and learning, these factors include curriculum, institution, teacher, and students. It can be deduced from the theory that in teaching and learning language as a category, not only focus on teacher and student factors but also other factors are relevant and affect each other to reach the learning goal. So understanding the four factors are critical in developing an effective language learning design. Effective learning language process creation is necessary to obtain synergy and maximum preparation of all the significant elements. The process in our educational environment will get us where we want to be.
Fracture initiation sequence of double-layer beam layers under three-point loading
Authors: Khvostunkov Kirill A.
Published: April 2023

The article deals with brittle failure of a two-layer beam under three-point loading conditions depending on the parameters under consideration — different proportions of thicknesses, Young’s moduli and strengths of both layers. Based on the equations of force and moment equilibrium, the dependences of the position of the beam neutral axis and its curvature are derived and the regions of parameters are determined, at which the failure begins earlier in the layer to which the load is applied than in the outer opposite layer to the load.
On group characterization by numbers of conjugate classes
Authors: Voskresenskaya Galina V.
Published: April 2023

Let c(n,G) be a number of conjugate elements of order n in a group G.In the article we study the problem of recognition of finite group by the set ncl(G) that consists of numbers c(n,G). We prove that Abelian groups can be recognized by the set ncl(G) when the order of the group is known. We also describe some other types of groups that can be recognized. The examples of non-isomorphic groups with the same sets ncl(G) are given. Some theorems about a group recognition by partial conditions on c(n,G). are proved.
About systems of vectors and subspaces in finite dimensional space recovering vectorsignal
Authors: Izbiakov Ilia M.
Published: April 2023

The subject of this paper are the systems of vectors and subspaces in finite dimensional spaces admitting the recovery of an unknown vector-signal by modules of measurements. We analyze the relationship between the properties of recovery by modules of measurements and recovery by norms of projections and the properties of alternative completeness in Euclidean and unitary spaces. The theorem on ranks of one linear operator is considered, the result of which in some cases can be regarded as another criterion for the possibility to restore a vector-signal. As a result of this work, the equivalence of the alternative completeness property and the statement of the rank theorem for Euclidean space is proved. It is shown that the rank theorem in the real case can be extended to the systems of subspaces.
The questions about the minimum number of vectors admissible for reconstruction by modules of measurements are considered. The results available at the moment are presented, which are summarized in the form of a table for spaces of dimension less than 10. Also the known results to the question of the minimum number of subspaces admitting reconstruction by the norms of projections are briefly given.
Reduction of the optimal tracking problem in the presence of noise
Authors: Sobolev Vladimir A.
Published: April 2023

In this paper, the decomposition method based on the theory of fast and slow integral manifolds is used to analyze the optimal tracking problem. We consider a singularly perturbed optimal tracking problem with a given reference trajectory in the case of incomplete information about the state vector in the presence of random external perturbations.
General theory of orthotropic shells. Part II
Authors: Velikanov Peter G. , Artyukhin Yuri P.
Published: April 2023

Modern mechanical engineering sets the tasks of calculating thin-walled structures that simultaneously combine sometimes mutually exclusive properties: lightness and economy on the one hand and high strength and reliability on the other. In this regard, the use of orthotropic materials and plastics seems quite justified.
The article demonstrates the complex representation method of the equations of orthotropic shells general theory, which allowed in a complex form to significantly reduce the number of unknowns and the order of the system of diferential equations. A feature of the proposed technique for orthotropic shells is the appearance of complex conjugate unknown functions. Despite this, the proposed technique allows for a more compact representation of the equations, and in some cases it is even possible to calculate a complex conjugate function. In the case of axisymmetric deformation, this function vanishes, and in other cases the influence of the complex conjugate function can be neglected.
Verification of the correctness of the proposed technique was demonstrated on a shallow orthotropic spherical shell of rotation under the action of a distributed load. In the limiting case, results were obtained for an isotropic shell as well.