bluuebunny/crossref_metadata_2025 huggingface dataset:
Together we can begin fixing public health globally
Authors: Cocores James A
Published: July 2022

It is irrefutable that most convenience and favored foods and beverages are the leading cause of morbidity and mortality worldwide. Government and private health agencies and organizations and cardiologists specifically, and clinicians in general, have failed and should be held liable for malpractice for pushing procedures and pills above longevity-lifestyle redirection for Maillard, alcohol, nicotine, and other drug abuse disorders. Particular lifestyle transitioning training for specific Maillard, alcohol, nicotine, fentanyl, and other drug misuse lifestyle transitioning programs have proven the most successful. And medical publishers and medical school deans to front-line medical clinicians and technicians are either unwilling or unable to conceptualize the basics of how lifestyle transitioning for substance misuse works. A must when trying to sell a joyous longevity lifestyle to themselves, their students, and their overweight residential and ambulatory guests. A detailed understanding of recovery lifestyle training programs is privy to a small number of experts globally, RL DuPont, NS Miller, and JA Cocores, for example. Specifics surrounding why Maillard foods are powerful opiate and dopaminergic agonists are clear to the author. Falsely arrested and silenced by the Florida Board of Medicine in February 2013 for putting lifestyle changes above the pharmaceutical industry and prescription cardiology and other pill-pushing by Hillary Clinton's Florida-based Drug Czar Dave Aronberg. The purpose of this article is to supply clinicians and healers with information surrounding why and how Maillard-coated favorite foods and beverages within each country behave like fentanyl and methamphetamine. And how to sell the unwanted proposition of helping unhappy browned-food compelled people slowly begin moving towards a joyous longevity lifestyle. These steps and much more should have been worldwide headlines over the past few decades. Instead, the world was distracted away from vital, joyous longevity lifestyle information by corporatocracies and autocratic governments posing as democracies that feed off their wealth and power. The world is perpetually distracted from what the average person is most concerned about by the so-called elite with a self-serving agenda. The elite-funded news of February 23, 2022, is no exception. Healers and everyday people need to begin fending for their joyous longevity lifestyle. These are the first baby steps and formulas to outlive the elites to once again form governments by and for the people.
Caracterização dos neonatos acometidos pela síndrome de abstinência neonatal: Uma revisão integrativa
Authors: Ferreira Juliana Alves , Guimarães Junior de Jesus , Costa Isabelle da Silva Santos , Dias Marília Pereira
Published: July 2022

A Síndrome de Abstinência Neonatal (SAN) é definida como a situação dos recém-nascidos que foram expostos a diferentes tipos de substâncias usadas pela mãe enquanto gestante, ou seja, ainda em sua fase intrauterina, fazendo com que estes apresentem dependência física às mesmas, podendo causar malformações e efeitos nocivos ao sistema nervoso, gastrointestinal e respiratório. Objetivo: Caracterizar os neonatos acometidos com a síndrome de abstinência e elencar os tipos de psicoativos que mais os acometem e suas respectivas manifestações clínicas. Metodologia: Estudo de revisão integrativa com busca nas bases de dados eletrônicas SCIELO, PUBMED e BVS, nos períodos de 2011 a 2021, sem restrições de idiomas. Resultados e Discussão: Foi possível identificar as características dos neonatos portadores da síndrome de abstinência por uso de substâncias psicoativas, bem como, elencar as manifestações clínicas que esses recém-nascidos apresentam, de acordo com o tipo de substância utilizada pela mãe durante a gestação. Notou-se ainda a importância da equipe multidisciplinar frente a essa patologia e a dificuldade de fechar o diagnóstico para tal, por se tratar de uma temática não tão estudada. Considerações finais: Diante das ações analisadas nota-se a importância de implementar estratégias que visem explorar de forma ampla as características que esses RN’s apresentam quando expostos a substâncias entorpecentes na fase de vida intrauterina, facilitando assim a avaliação e detecção precoce dessa síndrome.
Perspectivas sobre o potencial do Estado do Rio de Janeiro no setor produtor de bebidas e sua conexão com a área da engenharia química
Authors: Braga Amabilym Leal de Carvalho , Santos Cintia Marques dos , Santos Jordan Maciel dos , Oliveira Milena Borges de , Madureira Moisés Teles
Published: July 2022

O setor de bebidas constitui um importante papel na indústria de transformação do Brasil sendo um grande empregador em termos absolutos e com ampla distribuição geográfica da produção devido às características dos produtos. Além disso, deve-se ao seu peso econômico a atuação das grandes, pequenas e médias empresas que enfatizam a diferenciação como forma de competição. O Setor de bebidas do Estado do Rio de Janeiro conta com empresas e grupos de grandes marcas, além de destaque na área de destilados Premium, vinícolas, cervejarias artesanais e bebidas não alcoólicas. Este trabalho tem o objetivo de expor, sob um ponto de vista panorâmico, o potencial do Estado do Rio de Janeiro, como uma região que associa pontos de atração cultural e turística, com sua riqueza botânica, buscando dar ênfase a oportunidades para o desenvolvimento tecnológico de bebidas. Com base nas informações foi possível constatar que o estado oferece ao setor de bebidas um mercado consumidor muito favorável, leis de benefícios fiscais, estrutura para o Enoturismo e a biodiversidade da mata atlântica com frutas nativas pouco conhecidas e exploradas, e com grande potencial de aproveitamento para formulação e comercialização de novas bebidas tanto, alcoólicas como não alcoólica. Conclui-se que as evidentes oportunidades identificadas são fatores convidativos para que novos empreendimentos, com o apoio de entidades de fomento e suporte técnico sejam concretizados.
Fundamentos para fabricação de um medidor de deslocamento para determinação das constantes elásticas da madeira, considerando a sua anisotropia
Authors: Carrasco Edgar Valdimiro Mantilla , Alves Rejane Costa , Smits Mônica Azevedo , Pizzol Vinnicius Dordenoni , Oliveira Ana Lúcia Crespo , Mantilla Judy Norka Rodo
Published: July 2022

O objetivo deste trabalho é o desenvolvimento de um medidor de deslocamento portátil para determinar as constantes elásticas de madeiras brasileiras. As constantes elásticas que dão origem à matriz de flexibilidade foram determinadas através do ensaio de compressão em corpos de prova confeccionados com a orientação das fibras em seis direções: radial, tangencial, longitudinal, longitudinal-radial, longitudinal-tangencial e radial-tangencial. As espécies utilizadas foram: Dinizia excels (angelim vermelho), Apuleia leiocarpa (garapa) e Peltogyne discolor (roxinho). Com a finalidade de diminuir custo e tempo gasto, na colagem de extensômetros elétricos, foi desenvolvido um medidor de deslocamento, com exatidão suficiente para determinar as deformações em todas as direções das fibras e que possibilita a reutilização, do medidor de deslocamento, em outros ensaios de compressão. Utilizou-se uma tira de aço em forma de arco, na qual foram colados quatro extensômetros elétricos, sendo dois na parte superior e outros dois na parte inferior. Para obter maior sensibilidade na flexão e eliminar a influência da temperatura na deformação dos extensômetros elétricos, estes foram configurados em um circuito em ponte completa de Wheatstone, e logo conectados a um sistema de aquisição de dados. Os resultados permitiram concluir que os medidores de deslocamento foram eficientes e eficazes para determinar as deformações durante o ensaio de compressão e consequentemente para determinar todos os componentes da matriz de flexibilidade.
A terapia de Reiki e a saúde do trabalhador
Authors: Ramos Erica Lima , Vieira Giovana Cópio , Gomes Suelen Veras , Passos Joanir Pereira
Published: July 2022

Objetivo: Descrever os trabalhos acerca da terapia complementar Reiki no campo da saúde do trabalhador. Metodologia: Revisão integrativa, a qual utilizou-se as bases de dados da Biblioteca Virtual em Saúde, com seleção das bases LILACS, PubMed e SciELO, com recorte temporal entre 2012 e 2022. Foram identificadas 10.395 produções no total para todos os descritores utilizados nesta pesquisa, mas conforme os critérios de inclusão e exclusão, 05 artigos foram identificados e selecionados como relevantes ao estudo. Resultados: As produções selecionadas que contemplaram a pesquisa, demonstraram a importância do Reiki na questão da qualidade de vida, do cuidado e da necessidade de maior conhecimento na utilização desta prática integrativa visando a saúde do trabalhador. Conclusão: O Reiki é uma importante ferramenta no cuidado ao trabalhador, uma técnica que apresenta benefícios, uma visão holística do ser humano e por ser de baixo custo facilita a sua implementação. Por meio dos resultados das produções analisadas, ficou evidenciado que os sujeitos das pesquisas apresentaram melhoras dos sintomas relatados anteriormente as sessões da terapia de Reiki. Dessa forma, o Reiki promoveu melhorias da qualidade de vida dos sujeitos. A revisão revelou que existem poucas pesquisas que buscam comprovar a eficácia nos cuidados prestados utilizando o Reiki como uma intervenção, principalmente no campo da saúde do trabalhador.
Análise da assertividade do manejo do peso corporal associado a cinesioterapia de pacientes com diagnóstico de câncer de mama
Authors: Moreira Ana Jhennyfer da Silva , Lopes Suelen Tainá Lima , Silva Edileuda da , Garcia Gabriel Tavares , Ferreira Juliana Oliveira , Santos Thayse Costa dos , Carvalho Jade Vitória Duarte de , Carvalho Layse da Silva , Yamashiro Letícia Yuri de Lucena , Santos Edivaldo Serrão dos
Published: July 2022

O câncer se caracteriza pelo crescimento desordenado de células, que podem invadir tecidos adjacentes ou órgãos à distância. O tratamento dessa patologia possui diversas reações adversas, dentre elas o ganho de peso. Em vista disso, a cinesioterapia se torna de extrema importância para mulheres com esse diagnóstico, por ser uma abordagem fisioterapêutica que consiste no uso do movimento como terapêutica, sendo uma ferramenta indispensável para restabelecer a função de membros e movimentos. Analisar se há associação da conduta nutricional e a cinesioterapia no manejo de peso. Trata-se de uma revisão integrativa da literatura, com busca realizada no mês de maio a junho de 2022. Para seleção dos artigos, realizaram-se buscas nas principais bases de dados BVS (Virtual Health Library) e PubMed (National Library of Medicine), este com busca de livre acesso à base de dados MEDLINE. Observou-se que muitas mulheres com câncer de mama desconhecem os efeitos colaterais do tratamento e não são orientadas a procurar a fisioterapia, o que retarda sua reabilitação. Entretanto, estudos comprovam que o acompanhamento e desenvolvimento de treinos com exercícios elaborados pelo fisioterapeuta contribui na melhora da força muscular, para realização de tarefas diárias como também da autoestima e confiança, melhorando com isso a qualidade de vida e auxiliando no manejo do peso e do estado nutricional. É notável a importância da atividade física contribuindo na melhora da qualidade de vida das pacientes que apresentam neoplasia de mama, diminuindo seu risco e melhorando o prognóstico.
EVALUASI PROGRAM PEMBELAJARAN DI MADRASAH ALIYAH NEGERI AMBON
Authors: Jumaeda St
Published: July 2022

Abstract: This study aims to determine the implementation of PAI learning programs (al-Qur'an hadith, akidah ahlak, fikhi and SKI) using the evaluation of the stake countanance model program. The evaluation research includes three components, namely the components antecedent, transaction, and outcomes Thisresearch is a qualitative research using the countanance evaluation model. Data collection is carried out by interviews, observations and documentation. Data analysis is carried out through three lines of activities that occur simultaneously, namely data reduction, data presentation, and conclusion drawing/verification. The results showed that the PAI learning program had been implemented well. Based on the 7 aspects of evaluation contained in the antecendent component (curriculum, human resources, facilities and infrastructure) transaction (learning planning, implementation of learning and learning assessment) and outcomes (absorption of graduates in the world of work and universities) in general have gone well, but it is necessary to improve aspects of learning implementation on indicators of learning methods and the use of media learning.Keywords: Evaluation, PAI Learning, Stake Abstrak: Penelitian ini bertujuan untuk mengetahui pelaksanaan program pembelajaran PAI (al-Qur’an hadits, akidah ahlak, fikhi dan SKI) dengan menggunakan evaluasi program model stake countanance. Penelitian evaluasi meliputi tiga komponen yaitu komponen antecedent, transaction, dan outcomes. Penelitian ini adalah penelitian kualitatif dengan menggunakan model evaluasi countanance. Pengambilan data dilakukan dengan wawancara, observasi dan dokumentasi. Analisis data dilakukan melalui tiga alur kegiatan yang terjadi secara bersamaan yaitu reduksi data, penyajian data, dan penarikan kesimpulan/verifikasi. Hasil penelitian menunjukkan bahwa bahwa program pembelajaran PAI telah dilaksanakan dengan baik. Berdasarkan dari 7 aspek evaluasi yang terdapat dalam komponen antecendent (Kurikulum, SDM, sarana dan prasarana) transaction (perencanaan pembelajaran, pelaksanaan pembelajaran dan penilaian pembelajaran) dan outcomes (keterserapan lulusan di dunia kerja dan perguruan tinggi) secara umum telah berjalan dengan baik, namun perlu peningkatan pada aspek pelaksanaan pembelajaran pada indikator metode pembelajaran dan penggunaan media pembelajaran.Kata kunci: Evaluasi, Pembelajaran PAI, Stake
Evaluating the effect of nuclear inclusion X (NIX) infections on Pacific razor clam populations
Authors: Groner ML , Hershberger PK , Fradkin SC , Conway CM , Hawthorn AC , Purcell MK
Published: July 2022

Nuclear inclusion X (NIX), the etiological agent of bacterial gill disease in Pacific razor clams Siliqua patula, was associated with host mortality events in coastal Washington State, USA, during the mid-1980s. Ongoing observations of truncated razor clam size distributions in Kalaloch Beach, Washington, raised concerns that NIX continues to impact populations. We conducted a series of spatial and longitudinal NIX surveillances, examined archived razor clam gill tissue, and used population estimates from stock assessments to test whether (1) the prevalence and intensity of NIX infections is higher at Kalaloch Beach relative to nearby beaches, (2) infected gill tissue has features consistent with historical descriptions of NIX-associated histopathology, and (3) annual clam survival is inversely related to NIX infection prevalence and intensity. NIX prevalence exceeded 85% at all sampled locations, and infection intensity was the highest at Kalaloch Beach by 0.9-2.6 orders of magnitude. Kalaloch Beach clams revealed histopathology consistent with previous NIX epidemics, including enlarged and/or rupturing branchial epithelial cells, branchial necrosis, and high hemocyte densities. Estimated annual survival was 22% at Kalaloch Beach, and ranged between 57 and 99% at other study sites. NIX infection intensity (via quantitative PCR) was not significantly correlated with annual survival; however, annual survival was lowest at Kalaloch Beach, where infection intensities were highest, suggesting that clams can tolerate infections up to a lethal threshold. Collectively these data support the hypothesis that high NIX intensities are associated with host mortality. NIX-associated mortality appears to be more pronounced at Kalaloch Beach relative to other Washington beaches.
FURTHER PROFESSIONAL EDUCATION OF THE SOLDIERS OF THE ARMY OF THE CZECH REPUBLIC
Authors: KUBÍNYI LUBOMIR , BINKOVÁ KRISTÝNA , DAVIDOVÁ MONIKA , HOLCNER VLADAN , ODEHNAL JAKUB
Published: July 2022

The article presents some results of research . It deals with identifying the participation degree of military professionals in educational activities and identifying decisive motivational factors and barriers affecting participation in educational activities. The article is also aimed at analysing the influence of selected characteristics of age and the economic status of individuals. The analysis results show that no significant distinction in the representation of individual motives between the age groups has been proved. Statistically significant differences have been shown in the frequencies of responses expressing the evaluation of the significance of selected barriers by respondents with higher and lower military ranks.
NEW WORLD WORDS AND THINGS IN THE OLD WORLD: HOW THE AMERICAS CONQUERED THE WORLD
Authors: Kettunen Harri
Published: July 2022

What would world cuisine be without New World ingredients? What would pizza be without tomatoes, oriental food without chili, and Spanish omelette or kluski śląskie without potatoes? How would vanilla ice cream taste without vanilla? And what would movie nights be without popcorn and life without chocolate? New World products have enriched the lives of people globally for the past half a millennium, but how did all this happen? How did chili travel to Asia? And why is turkey called turkey in English, hindi in Turkish, peru in Portuguese, and “Roman chicken” in Arabic? This article explores the ongoing conquest of the world by New World words and things, tracing their origins and travel routes, as well as the ever-changing nature of indigenous American loanwords in the languages of the world, including school children’s perceptions of these words: why is ocelot a “Minecraft cat,” an anorak a “fine jacket,” and a tomahaw a “tactical intercontinental missile”?
Pemodelan Nilai Koefisien Manning Terhadap Karakteristik Hidraulika Dalam Simulasi Banjir Menggunakan HEC-RAS Pada DAS Landak, Kalimantan Barat
Authors: Haque Laily Fadhilah Sabilal , Banurea Irene Yovita Br. , Sikana Arina Mana , Prastica Rian Mantasa Salve
Published: July 2022

Banjir adalah masalah serius bagi banyak negara di dunia. Begitu pula halnya dengan Kabupaten Landak yang terletak di Provinsi Kalimantan Barat. Permasalahan banjir pada daerah tersebut adalah bencana bagi masyarakat lokalnya. Penelitian ini bertujuan untuk mengetahui berapa besaran debit banjir rancangan pada daerah tinjauan serta menawarkan alternatif skenario solusi permasalahan dalam mengatasi permasalahan daerah studi. Metode penelitian berupa analisis numerik dengan rumus serta bantuan aplikasi untuk menggambarkan visualisasi dari keadaan yang terjadi, dimulai dari analisis DAS, perhitungan hidrologi dan hidraulika, dan pemodelan numerik untuk visualisasi tinggi muka air menggunakan software HEC-RAS. Berdasarkan data sekunder yang diperoleh, analisis curah hujan untuk kala ulang 50 tahun menghasilkan debit banjir Nakayasu sebesar 13884,02 m³/detik. Nilai tersebut selanjutnya digunakan untuk simulasi pada aplikasi HEC-RAS. Skenario yang digunakan saat simulasi adalah dengan aliran tetap (steady flow). Hasil simulasi bermanfaat untuk menggambarkan pilihan solusi permasalahan yang akan ditentukan di akhir penelitian.
Analisis Saluran Drainase di Pusat Kota Jepara dengan Program EPA SWMM 5.1 dan HEC RAS 4.1.0
Authors: Fauziah Shiska , Wahyudi Slamet Imam , Poedjiastoeti Hermin
Published: July 2022

Dari data nilai lahan yang bersumber dari Badan Pusat Statistik Kabupaten Jepara bahwa di Kelurahan Panggang, Kecamatan Jepara pengalihan fungsi lahan untuk bangunan sangat tinggi yaitu menunjukkan persentase sebesar 70,98 %, Oleh karena itu mengakibatkan area terbuka pada Kabupaten Jepara untuk resapan air hujan khususnya di ruas jalur utama menjadi berkurang sehingga mengakibatkan banjir dan genangan air di lokasi pusat kota.  Banjir  yang terjadi tingginya mencapai 40 cm sampai 80 cm saat hujan turun area pusat perkotaan terdapat beberapa titik genangan di alun – alun Jepara, jalan kartini, dan kawasan pecinan jepara, dan beberapa ruas jalan lainnya. Pada saluran yang ada di Kelurahan Panggang merupakan salah satu prasarana yang mendukung berfungsinya suatu sistem perkotaan di Kota Jepara. Pada saluran yang ada disepanjang daerah Kali Wiso tersebut sering terjadi genangan setiap musim hujan maka perlu dilakukan kajian untuk menganalisis kapasitas saluran drainase tersebut. Data yang digunakan dalam perencanaan adalah data sekunder. Data sekunder diperoleh dari gambar skema saluran drainase dan data mengenai dimensi saluran serta data hidrologi. Data hidrologi dan hidraulika yang diperoleh kemudian dianalisis untuk memperoleh debit rencana dan kapasitas saluran drainase. Debit rencana dihitung dengan menggunakan metode rasional dan kapasitas saluran dihitung dengan permodelan software HEC RAS 4.1.0  dan EPA SWMM 5.1. Penelitian ini mengkaji tentang Analisa Kapasitas Saluran Drainase untuk mengevaluasi banjir berdasarkan kondisi eksisting saluran drainase yang mempengaruhi terjadinya banjir dengan menggunakan permodelan software HEC RAS 4.1.0  dan EPA SWMM 5.1.  Software HEC RAS 4.1.0 . Berdasarkan hasil analisa hidrologi bahwa distribusi yang dipilih adalah Distribusi Gumbel Tipe  I dan Distribusi Log Pearson Tipe III. Pada uji kecocokan disimpulkan bahwa metode distribusi Log Pearson Tipe III memenuhi persyaratan karena nilai  Dmax -0.0202 kurang dari Do 0.41. dan analisa hidrualika diperoleh dengan software HEC RAS 4.1.0  dan EPA SWMM 5.1. pada kala ulang 1 tahun terdapat 2 titik yang mengalami banjir dan 4 titik yang mampu menampung debit banjir . Titik – titik banjir tersebar dibeberapa daerah di Kelurahan Panggang , yaitu Jl. RA. Kartini dan Jl. Pemuda. Dalam mengatasi banjir diperlukan perencanaan ulang drainase kala ulang 10 tahun guna menciptakan keamanan dan kenyamanan bagi warga sekitar.
Evaluasi Kegagalan Dinding Penahan Tanah Pada Lereng Jalan Raya Rembangan Kabupaten Jember
Authors: Lestari Ayu Dwi , Putra Paksitya Purnama , Nurtjahjaningtyas Indra
Published: July 2022

Dinding penahan tanah tipe beton bertulang dibangun pada tahun 2017 untuk memperkuat stabilitas lereng Jalan Raya Rembangan, Kabupaten Jember. Namun, pada tahun 2018 bangunan tersebut mengalami kegagalan. Hingga saat ini, penyebab kegagalan dari dinding penahan tanah tersebut masih belum diketahui. Penelitian ini bertujuan untuk mengevaluasi penyebab kegagalan dinding penahan tanah terhadap stabilitas dinding penahan tanah pada lereng jalan raya Rembangan Kabupaten Jember. Metodologi penelitian dimulai dengan pengumpulan data primer maupun sekunder, kemudian dilakukan pengolahan data dengan metode konvensional dan menggunakan program bantu. Setelah dilakukan pengolahan data, dilakukan analisis data hingga ditemukan kesimpulan penyebab kegagalan dinding penahan tanah. Berdasarkan  hasil analisis, dinding penahan tanah memiliki tingkat faktor keamanan yang rendah terhadap stabilitas guling, stabilitas geser, serta stabilitas daya dukung. Faktor keamanan terhadap daya dukung pondasi tiang grup sebagai perkuatan dinding penahan tanah juga menunjukkan nilai yang lebih kecil daripada yang dibebankan. Selain itu, pondasi tiang grup tersebut dapat mengalami penurunan total sebesar 1,28 m.
Orientasi Tafsir Turjuman Al-Mustafid Karya Abdur Rauf Al-Singkili
Authors: Faqih Sahlan Muhammad , Rusmana Dadan , Rahtikawati Yayan
Published: July 2022

This article discusses the study of the interpretation orientation (ittijah al-mufassir) of Tarjuman al-Mustafid, as a pioneer in the development of the 'fardi' (individual) interpretation of Nusantara in the Century. This article uses a qualitative approach and an exploratory-phenomenological approach. Al-Singkili's scientific odyssey to the Arabian Peninsula to the 'maqam' that has matured in various sciences. After returning to Aceh, al-Singkili was appointed mufti of the kingdom by contributing to the thought and administrative aspects. The lineage of thought of the sanad al-Singkili is directly related to the author of 'Tafsir al-Jalalain'. As a stream of practical Sufism (Tasawwuf Al-'Amali) and the depth of Shari'a knowledge that he controls, he always thinks moderately in making decisions and religious fatwas. This can be done in his response when faced with a mystical dispute that occurred between the thoughts of Hamzah al-Fanzhuri and Nuruddin al-Raniri. Al-Singkili tried to be moderate without making accusations, but did not agree with al-Raniri's position. This wasathiyyah thought can be found in the explanations presented in his commentary when faced with anthropopomorphic verses.
Integrasi Ilmu Keislaman dan Sosial Humaniora dalam Studi Islam: Kritik Epistemologi Muhammad Arkoun terhadap Metodologi Studi Islam
Authors: Dzukroni Arisy Abror
Published: July 2022

Arkoun sees a stagnation in religious studies experienced by many researchers, either by Muslims (insiders) or by non Muslims such as orientalists or occidentalists (outsiders). This is due to Arkoun's study of Islam which is logocentric, which is only centered on one opinion. This phenomenon continues to the point that people see Islam as Islamism, not Islamology. This paper wants to reveal how the responses and solutions offered by Arkoun in addressing this phenomenon. This research uses qualitative methodology and literature study. Arkoun offers the concept of deconstruction, which eliminates the construction of old knowledge buildings and offers new ones. To achieve this, Arkoun proposed the methodology of appliance islamology as a new way of reading Islam. One of them is with intertextuality, a reading Islamic religious sources with various scientific approaches, including social sciences and humanities. Although he received some criticism from various parties, however with his new reading, Arkoun found a new concept in Islamic studies that was more in line with the times..
The Depiction of Woman's Roles in Shakespeare’s Othello
Authors: Hikmah Durratul , Astutik Astutik
Published: July 2022

William Shakespeare’s Othello is a drama that tells about the woman’s femininity power in her role. Here, Desdemona as the central female character becomes the main focus in this research. This study aims to reveal woman’s roles depicted by Shakespeare in Othello and describe the factors affecting them. This study used the literary criticism with the theory of cultural feminism. This research is a type of descriptive qualitative research. From this research, two findings can be stated as the answer of the problems of the study. The first is, the roles of woman in Shakespeare’s play Othello are woman as a wife, woman as caretaker, and woman as peacemaker. From those roles, the researcher finds that the factors that affect woman’s roles in the drama are relationship and personal factors.
OVERVIEW OF THE CONCEPT OF KHIYAR AL AIB IN E-COMMERCE PRACTICE
Authors: Sri Rejeki Niniek Mumpuni
Published: July 2022

The rapid development of buying and selling online gave birth to various problems related to the shift in traditional buying and selling which developed into buying and selling through the internet world. The ease of transactions obtained through the internet media must be followed by strong protection for consumers, considering that the goods traded cannot be seen and held directly. The choice to determine whether the consumer can continue the sale and purchase contract or cancel it has been regulated in Islamic law, this right to choose is called khiyar. This Khiyar right is a form of protection for consumers. If it is known that the goods traded have defects, then with the validity of khiyar al-aib, consumers can return and replace them with new ones without defects, or cancel the contract with a refund, or can also sincerely accept the defect with a reduced price, all of which are returned to the customer. the parties by mutual agreement. The review of the Khiyar Al-Aib concept in E-commerce in Indonesia by taking the example of the Shopee marketplace aims to analyze that the development of e-commerce is also followed by consumer protection efforts by the application of khiyar al-aib. The research method is normative law by examining a collection of legal materials related to consumer rights, the Consumer Protection Act, provisions in Islamic law. Consumer dissatisfaction with online buying and selling transactions can be followed up with the implementation of the principles and concepts of khiyar al-aib. This review of khiyar al-aib is to understand that the concept of consumer protection in Islam already exists and can be applied to online trading transaction.
Multimedia Development Of Science Learning Based On Science Literacy on The Theme of Lightning
Authors: Yuningsih Winda , Permanasari Anna , Permana Irvan
Published: July 2022

This study aims to obtain: (1) multimedia design in science learning on the theme of lightning based on science literacy, (2) student science literacy information after multimedia-assisted science learning on the lightning theme, (3) student response information to multimedia in science learning based on science literacy on the lightning theme. The method used in this study was Research and Development with the ADDIE model, while the research design used pre-experimental pre-test post test only. The population in this study was grade IX students of one of the junior high schools in Cianjur district for the 2016-2017 academic year with a sample of 31 people determined using the purposive sample method. To test the feasibility of multimedia, judgments were carried out by expert lecturers, while students' science literacy data was collected by providing science literacy questions and student responses regarding multimedia were collected through questionnaires given to students. Based on the results of judgments of material experts and lecturers, it shows that aspects of multimedia design quality, aspects of multimedia attractiveness, aspects of multimedia interactiveness and aspects of material conformity with the curriculum are included in the category of excellent. From the results of data processing, it was obtained that students' science literacy abilities had a significant increase in pre-test and post-test scores. Meanwhile, students' responses to multimedia are very good in the aspect of science literacy content and aspects of potential to increase motivation, while in the aspect of ease of operating multimedia the category is good.
The Improvement of Critical Thinking Skill And Concept Mastery Through Problem Based Learning Using The Strategy Of Mind-Map On Ecosystem Lesson
Authors: Fikriyah Tia Ghozwatul , Istiadi Yossa , Ardianto Didit
Published: July 2022

This research aims to improve the concept mastery and critical thinking skill of students on the lesson of ecosystem. The method used in this research was quasi-experimentalal with Pre-post test only design. This research was conducted at Islamic Senior High Scholl (Madrasah Aliyah) in Karawang District. There were total 40 objects in both control and experimentalal class. The instruments used are essay, multiple choices test, questionnaire, and observation. The result of this research shows that the using of Problem-Based Learning model with Mind-Map strategy has an average score of 80 in concept mastery and 75 in critical thinking skill. The research shows that the N-gain of critical thinking skill in experimentalal class was 68 (middle criteria), meanwhile the N-gain of concept mastery was 78 (high criteria) and the respond in this class was more enthusiastic. The students’ activity in the class after being observed was improved since the students could understand the lesson more properly. This shows that Problem-Based Learning with Ming Map strategy can improve critical thinking skill and concept mastery.
IDENTIFIKASI MINAT BELAJAR SISWA TERHADAP MATA PELAJARAN FISIKA DI SMAN 1 MUARO JAMBI
Authors: Aldila Febri Tia , Matondang Maria Marisa , Wicaksono Langgengyoga
Published: July 2022

Tujuan penelitian ini adalah untuk mengidentifikasi minat belajar siswa pada mata pelajaran fisika di SMAN 1 Muaro JAMBI. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif. Populasi penelitian ini adalah siswa kelas X MIPA di SMAN 1 Muaro Jambi. Instrumen penelitian yang digunakan adalah angket minat belajar siswa pada mata pelajaran fisika. Teknik pengambilan sampel dalam penelitian ini yang berguna untuk pengolahan data adalah purposive sampling dimana data yang diolah adalah data kuantitatif. Selanjutnya data di analisis dengan teknik analisis kuantitatif menggunakan statistik deskriptif. Hasil penelitian ini menunjukkan bahwa minat belajar siswa pada mata pelajaran fisika kelas X MIPA di SMAN 1 Muaro Jambi berada pada kategori baik (53,3%), kategori sangat baik (45,7%), dan kategori tidak baik (1,1%).
Problem-Based Learning with Science, Technology, Engineering, and Mathematics (Stem) Approach to Improve Critical Thinking Skills and Conceptual Understanding of Junior High School Students
Authors: Setyorini Rr. Arum , Permanasari Anna , Ardianto Didit
Published: July 2022

This research has done to examine the application of learning with PBL STEM model implemented in one of State Junior High School in Bogor. The method used in this research was quasi experiment with pre-post control design. The experimental class was treated with PBL STEM model, while the control class with PBL model 5M. The subjects involved were 76 students of Junior High School in one of Bogor City, divided into 38 students in experimental class 38 students in control class. Data collection techniques conducted in this study through observation, tests, and questionnaires. Data analysis was performed using quantitative data analysis and qualitative data analysis. The research shows the increasing of student’s critical thinking skill high category (N-Gain value is 70.78%). The Implementation of PBL STEM could improve the concept gaining with the N-Gain value is as much as 69.56%. So, it can be concluded that problem-based learning with STEM approach is appropriate to be implemented in junior high school students of class VIII. In addition, students' responses showed positive results can be seen from the increased interest, liveliness, motivation, in studying the field of STEM.
A Novel In Vitro Platform Development in the Lab for Modeling Blast Injury to Microglia
Authors: Xu Dasen , Zhang Nu , Wang Sijie , Yu Yawei , Zhang Pan , Li Yulong , Yang Hui
Published: July 2022

Traumatic brain injury (TBI), which is mainly caused by impact, often results in chronic neurological abnormalities. Since the pathological changes in vivo during primary biomechanical injury are quite complicated, the in-depth understanding of the pathophysiology and mechanism of TBI depends on the establishment of an effective experimental in vitro model. Usually, a bomb explosive blast was employed to establish the in vitro model, while the process is complex and unsuitable in the lab. Based on water-hammer, we have developed a device system to provide a single dynamic compression stress on living cells. A series of amplitude (∼5.3, ∼9.8, ∼13.5 MPa) were generated to explore the effects of dynamic compression loading on primary microglia within 48 h. Apoptosis experiments indicated that primary microglia had strong tolerance to blast waves. In addition, the generation of intercellular reactive oxygen species and secretory nitric oxide was getting strongly enhanced and recovered within 48 h. In addition, there is a notable release of pro-inflammatory cytokine by microglia. Our work provides a reproducible and peaceable method of loading single dynamic compression forces to cells in vitro. Microglia showed an acute inflammatory response to dynamic loadings, while no significant cell death was observed. This insight delivers a new technological approach that could open new areas to a better understanding of the mechanism of cell blast injuries.
A Novel Crosslinking Method for Improving the Anti-Calcification Ability and Extracellular Matrix Stability in Transcatheter Heart Valves
Authors: Qi Xiaoke , Jiang Zhenlin , Song Mingzhe , Tang Zhenjie , Xie Xinlong , Liu Yuhong , Wu Qiying , Wu Zhongshi
Published: July 2022

More than 200,000 patients with aortic diseases worldwide undergo surgical valve replacement each year, and transcatheter heart valves (THV) have been more widely used than ever before. However, THV made by the glutaraldehyde (Glut) crosslinking method has the disadvantage of being prone to calcification, which significantly reduces the durability of biomaterials. In this study, we applied a novel crosslinking method using ribose in THV for the first time, which can decrease calcification and increase the stability of the extracellular matrix (ECM). We incubated the bovine pericardium (BP) in ribose solution at 37°C by shaking for 12 days and confirmed that the structure of the BP was more compact than that of the Glut group. Moreover, the ribose method remarkably enhanced the biomechanical properties and provided reliable resistance to enzymatic degradation and satisfactory cellular compatibility in THV. When the BP was implanted subcutaneously in vivo, we demonstrated that ECM components were preserved more completely, especially in elastin, and the immune-inflammatory response was more moderate than that in the Glut treatment group. Finally, the ribose-cross-linked materials showed better anti-calcification potential and improved durability of THV than Glut-cross-linked materials.
Digital Transformation and Organizational Learning: Situated Perspectives on Becoming Digital in Architectural Design Practice
Authors: Gardner Nicole
Published: July 2022

The architecture, engineering, and construction (AEC) industry is negotiating a slow and fragmented shift toward digital transformation (DT). To identify the drivers and barriers to DT in the AEC industry, this article draws on organizational learning theory. More specifically, it investigates learning dynamics related to digital technology knowledge and skills development in organizations in the architecture sector. Adopting an empirical approach, the research has collected data through a series of semi-structured interviews (n = 17) with employees from four large-scale architecture organizations in Sydney, Australia. The article conceptualizes the interviewees’ experiences of engaging with digital technology knowledge and skills in their workplace along a learning loop continuum and in relation to modes of single-, double-, and triple-loop learning. It finds that organizations are primarily fostering modes of single-loop learning and potentially missing opportunities to innovate. The research highlights the hybrid, extensible, and platform nature by which individuals “learn” digital technologies and computational systems in the architecture workplace and identifies opportunities for intervention. The research demonstrates the utility of organizational learning as a method to rethink approaches to DT in the AEC industry.
Finding Correlations Between mRNA and Protein Levels in Leishmania Development: Is There a Discrepancy?
Authors: Cortazzo da Silva Leonardo , Aoki Juliana Ide , Floeter-Winter Lucile Maria
Published: July 2022

Multiple genes and proteins have been identified as differentially expressed in the stages of the Leishmania life cycle. The differentiation processes are implicated in specific transcriptional and proteomic adjustments driven by gene expression regulation mechanisms. Leishmania parasites lack gene-specific transcriptional control, and gene expression regulation mostly depends on posttranscriptional mechanisms. Due to the lack of transcriptional regulation, criticism regarding the relevance of transcript quantification as a possible and efficient prediction of protein levels is recurrent in studies that use transcriptomic information. The advent of high-throughput technologies has improved the analysis of genomes, transcriptomes and proteomes for different organisms under several conditions. Nevertheless, defining the correlation between transcriptional and proteomic profiles requires arduous and expensive work and remains a challenge in Leishmania. In this review, we analyze transcriptomic and proteomic data for several Leishmania species in two different stages of the parasite life cycle: metacyclogenesis and amastigogenesis (amastigote differentiation). We found a correlation between mRNA and protein levels of 60.9% and 69.8% for metacyclogenesis and amastigogenesis, respectively; showing that majority mRNA and protein levels increase or decrease concomitantly. Among the analyzed genes that did not present correlation indicate that transcriptomic data should be carefully interpreted as protein expression. We also discuss possible explanations and mechanisms involved for this lack of correlation.
Associations Between 25-Hydroxyvitamin D and Total and γ' Fibrinogen and Plasma Clot Properties and Gene Interactions in a Group of Healthy Black South African Women
Authors: Rautenbach Petro H. , Nienaber-Rousseau Cornelie , de Lange-Loots Zelda , Kruger Iolanthé M. , Pieters Marlien
Published: July 2022

The role of 25-hydroxyvitamin D [25(OH)D] in reducing the risk of cardiovascular disease (CVD) has been recognized, but the mechanisms involved are unclear. Researchers have discovered a link between vitamin D and fibrinogen. Until now, data on the relationship between vitamin D and the γ' splice variant of fibrinogen and fibrin clot characteristics remain unexplored. In this study, 25(OH)D, total and γ' fibrinogen, as well as turbidimetrically determined plasma clot properties, were quantified, and fibrinogen and FXIII SNPs were genotyped in 660 Black, apparently healthy South African women. Alarmingly, 16 and 45% of the women presented with deficient and insufficient 25(OH)D, respectively. Total fibrinogen and maximum absorbance (as a measure of clot density) correlated inversely, whereas γ' fibrinogen correlated positively with 25(OH)D. γ' fibrinogen increased whereas maximum absorbance decreased over the deficient, insufficient, and sufficient 25(OH)D categories before and after adjustment for confounders. 25(OH)D modulated the association of the SNPs regarding fibrinogen concentration and clot structure/properties, but did not stand after correction for false discovery rate. Because only weak relationships were detected, the clinical significance of the findings are questionable and remain to be determined. However, we recommend vitamin D fortification and supplementation to reduce the high prevalence of this micronutrient deficiency and possibly to improve fibrinogen and plasma clot structure if the relationships are indeed clinically significant. There is a need for large cohort studies to demonstrate the relationship between vitamin D and cardiovascular and inflammatory risk factors as well as to uncover the molecular mechanisms responsible.
The Roads We Take: Cellular Targets and Pathways Leading Biologics Across the Blood–Brain Barrier
Authors: Baghirov Habib
Published: July 2022

Biologics are at the frontier of CNS disease treatment. This applies both to therapeutic molecules such as peptides, antibodies and RNA interference agents, and to delivery vehicles of biological origin such as viral vectors and extracellular vesicles. Unlike small molecules, biologics are not likely to diffuse across cell membranes. To get into and across brain capillary endothelial cells (BCEC) forming the blood–brain barrier, they normally employ active, energy-dependent processes. They can initiate these processes non-specifically or trigger them by interaction with various receptor or transporter molecules at the luminal surface of BCEC. Designing biologics to use this specific engagement is more common in smaller formats, especially peptides and antibodies, but can also apply to targeted vehicles. This targeted design has employed a number of molecules expressed on BCEC – the transferrin receptor being the most common example, although there has been progress in identifying molecules that are even more specific to BCEC. In addition, the format of biologics and a multitude of their biophysical properties affect the way they interact with BCEC, and this diversity is even more salient between different classes of biologics. It affects the entire span of interaction with BCEC, from the initial engagement at the luminal surface to intracellular sorting, and eventually, entrapment or routing toward exocytosis into the brain parenchyma. In this article, I reviewed the progress in identifying novel targets that make the interactions between biologics and BCEC more specific, and in our understanding of the interplay between the properties of biologics and these interactions.
The Small Strain Stiffness Properties of Undisturbed Weathered Granite With Different Weathering Degrees
Authors: Wang Juntao , Kong Lingwei , Li Chengsheng , Liu Bingheng , Yan JunBiao
Published: July 2022

To evaluate the small strain stiffness properties of undisturbed weathered granite, the circular computer numerical control (CNC) abrasive wire sawing technology was applied to weathered granite sample processing and a series of resonance column tests were carried out to study the effects of weathering degree and effective consolidation pressure on dynamic shear modulus of undisturbed weathered granite. The results show that the degree of weathering and effective consolidation pressure have significant effects on the small strain stiffness properties of weathered granite. The samples with lower weathering degrees have higher dynamic shear modulus under the same effective consolidation pressure. The maximum dynamic shear modulus of samples with higher weathering degrees is more sensitive to effective consolidation pressure. Besides, a comparison between the experimental results with the previous results from other researchers indicates that the dynamic shear modulus ratio of weathered granite in the study area exceeds the parameter range obtained from others. According to the experimental results, a mathematical model of the relation between corrected standard penetration test (SPT) N’ value and dynamic shear modulus was established, and besides, the variation range of dynamic shear modulus ratio of weathered granite in the study area was given, which may provide a reference for dynamic stability analysis of engineering in the study area.
Adipocyte-Cancer Cell Interactions in the Bone Microenvironment
Authors: Otley Meredith O. C. , Sinal Christopher J.
Published: July 2022

When compared to adipocytes in other anatomical sites, the interaction of bone marrow resident adipocytes with the other cells in their microenvironment is less well understood. Bone marrow adipocytes originate from a resident, self-renewing population of multipotent bone marrow stromal cells which can also give rise to other lineages such as osteoblasts. The differentiation fate of these mesenchymal progenitors can be influenced to favour adipogenesis by several factors, including the administration of thiazolidinediones and increased age. Experimental data suggests that increases in bone marrow adipose tissue volume may make bone both more attractive to metastasis and conducive to cancer cell growth. Bone marrow adipocytes are known to secrete a variety of lipids, cytokines and bioactive signaling molecules known as adipokines, which have been implicated as mediators of the interaction between adipocytes and cancer cells. Recent studies have provided new insight into the impact of bone marrow adipose tissue volume expansion in regard to supporting and exacerbating the effects of bone metastasis from solid tumors, focusing on prostate, breast and lung cancer and blood cancers, focusing on multiple myeloma. In this mini-review, recent research developments pertaining to the role of factors which increase bone marrow adipose tissue volume, as well as the role of adipocyte secreted factors, in the progression of bone metastatic prostate and breast cancer are assessed. In particular, recent findings regarding the complex cross-talk between adipocytes and metastatic cells of both lung and prostate cancer are highlighted.