bluuebunny/crossref_metadata_2025 huggingface dataset:
Actualizaciones en El Manejo de la Hiperuricemia en el Primer Nivel De Atención
Authors: Albán Pinzón Jeniffer Victoria
Published: May 2024

La hiperuricemia es una condición común en la población, que se caracteriza por niveles elevados de ácido úrico en la sangre, siendo de 7 mg/dl en hombres y 6 mg/dl en mujeres. Se produce debido a un desequilibrio entre la producción y la eliminación de este metabolito, y puede ser precursor de enfermedades como la gota, problemas renales, hipertensión, obesidad, entre otras. El tratamiento de la hiperuricemia se da tomando en consideración el cuadro clínico del paciente. En pacientes asintomáticos, se considera el uso de fármacos hipouricemiantes en casos específicos como neoplasias, niveles altos de ácido úrico o disfunción renal. En pacientes sintomáticos, se recomienda el uso de alopurinol como fármaco de primera línea. Sin embargo, en casos de intolerancia o falta de respuesta a este medicamento, se puede optar por febuxostat. El objetivo del presente articulo es mejorar el manejo de la hiperuricemia para evitar sus complicaciones en el primer nivel de atención, para ello la metodología de este trabajo de investigación se enmarcó en una revisión bibliográfica.
Beneficios y Consideraciones de la Aplicación Tópica de la Leche Materna
Authors: Noboa Pullaguari Kevin David
Published: May 2024

La lactancia materna es un pilar fundamental en la salud y el bienestar tanto del bebé como de la madre, en la actualidad, la importancia de la lactancia materna se respalda con una amplia evidencia científica que demuestra sus innumerables beneficios tanto a corto como a largo plazo. Esta práctica proporciona nutrientes esenciales y anticuerpos que fortalecen el sistema inmunológico del bebé, a su vez reduce el riesgo de diversas enfermedades en la infancia y promueve un desarrollo cognitivo óptimo. La lactancia materna beneficia a la madre al reducir el riesgo de ciertas enfermedades, promover una recuperación más rápida del parto y fomentar un vínculo emocional madre-hijo. La leche materna además ofrece una gama de beneficios para la cicatrización de afecciones cutáneas en los bebés, sus propiedades antimicrobianas, protegen contra infecciones al prevenir la colonización bacteriana. Además, los factores de crecimiento y células madre presentes en la leche materna estimulan la regeneración celular y la formación de nuevos tejidos en la zona de la herida, acelerando el proceso de cicatrización y mejorando la calidad de la piel afectada. La leche materna ha demostrado efectividad en afecciones cutáneas como dermatitis atópica, dermatitis del pañal y cura del cordón umbilical.
ADJUSTABLE NITROOXIDATION TECHNOLOGY FOR LOW ALLOY STEEL
Authors: Alimardonovich Berdiev Sherzod
Published: May 2024

The article discusses the production of a surface diffusion nitride-oxide layer on low-alloy structural steel with specified structures and properties.
To develop a controlled technology for nitro-oxidation of low-alloy carbon steel, the dependences of the composition and structure of the nitrided and oxide layer on the chemical composition of the steel and the technological parameters of the process were studied. Technical iron was used as a model alloy and samples of industrial steel grades 40X, P6M5 and steel 45 were processed. Saturation temperatures were studied in the ranges above and below the eutectoid temperature for the “Fe-N” system and, accordingly, for the “Fe-O” system and it was found that the best structures are at saturation temperatures below the eutectoid
ADJUSTABLE NITROOXIDATION TECHNOLOGY FOR LOW ALLOY STEEL
Authors: Berdiev Sherzod Berdiev Sherzod
Published: May 2024

The article discusses the production of a surface diffusion nitride-oxide layer on low-alloy structural steel with specified structures and properties.
To develop a controlled technology for nitro-oxidation of low-alloy carbon steel, the dependences of the composition and structure of the nitrided and oxide layer on the chemical composition of the steel and the technological parameters of the process were studied. Technical iron was used as a model alloy and samples of industrial steel grades 40X, P6M5 and steel 45 were processed. Saturation temperatures were studied in the ranges above and below the eutectoid temperature for the “Fe-N” system and, accordingly, for the “Fe-O” system and it was found that the best structures are at saturation temperatures below the eutectoid
Oral health and nutritional status in care-dependent, community-dwelling older adults in Zurich, Switzerland
Authors: Angst Lea , Ferreira Lourenço Patricia D. , Srinivasan Murali
Published: May 2024

The aim of this study was to assess the oral health status (OHS), Oral health impact profile (OHIP-G-14), and the nutritional status (NS) in community-dwelling, dependent older adults. Information on OHS including DMF(T), plaque (PI) and gingival (GI) indices, community-periodontal-index-for-treatment-needs (CPITN), OHIP-G-14, maximum bite force (MBF), chewing efficiency [subjective (SA) and quantitative (VoH) assessments] were collected. NS was obtained by Mini-nutritional assessment (MNA) and body mass index (BMI). Cognitive status was evaluated by the mini-mental state examination (MMSE). 240 elders (mean-age = 81.5 ± 8.9y; men =85, women =155) were recruited. Average number of teeth, functional occlusal units and DMF(T), were 18.8 ± 8.9, 7.7 ± 3.5, and 22.3 ± 5.3 respectively. Mean PI, GI, CPITN and OHIP-G-14 were 1.8 ± 0.8, 1.2 ± 0.8, 1.9 ± 1.1, and 8.0 ± 12.0, respectively. MBF, VoH, SA were 219.6 ± 193.6, 0.3 ± 0.2, and 3.3 ± 1.4, respectively. MNA and BMI were 22.9 ± 4.7 and 25.5 ± 5.3, respectively. Number of teeth reduced significantly with age (P < 0.001), cognitive decline (P < 0.001). Oral hygiene significantly deteriorated with cognitive decline (P < 0.001). OHIP scores were negatively affected by increasing cognitive decline (P < 0.001). MNA deteriorated in women (P = 0.026), with increasing age (P = 0.015), and advancing cognitive decline (P < 0.001). BMI reduced with advancing age (P = 0.003) and in women (P = 0.016). Based on the findings of this study, it may be concluded that advancing age and cognitive decline, negatively impacted the oral health, oral function, oral health-related quality of life, and the nutritional state of care-dependent community-dwelling older adults.
Crimean-Congo hemorrhagic fever: a future health issue in France? What about Romania?
Authors:   “Ion Ionescu de la Brad” Iasi University of Life Sciences; UMS28, Sorbonne Université/INSERM, Paris, France, Serban Morosan , Andreea Cozma ,   “Ion Ionescu de la Brad” Iasi University of Life Sciences, Anca Dascalu ,   “Ion Ionescu de la Brad” Iasi University of Life Sciences, Stephane Marot ,   Pierre Louis Institute of Epidemiology and Public Health, Paris; and Pitié-Salpêtrière University Hospital, Paris
Published: May 2024

Crimean Congo Hemorrhagic Fever Virus (CCHFV) is the etiological agent of a severe hemorrhagic fever affecting Africa, Asia and southern Europe. In recent decades, climate change has led to an increase in the distribution range of this virus. Little scientific data is yet available on the interactions with its vector, the tick, or on its biology. However, the confirmed presence of human infections in Spain and positive serologies in Corsican livestock could well focus attention on this pathogen. This review takes stock of developments in eco-epidemiological knowledge of this virus, particularly in Europe and especially in France. What about Romania ?
Researches regarding the paraclinical correlations between urinalysis and water intake in cats with feline urologic syndrome
Authors:   USAMV Bucharest, B. Alexandru Vițălaru , Alina Ștefănescu ,   USAMV Bucharest
Published: May 2024

The research aimed the direct correlations between the water composition and feline urological syndrome prognosis. The study was conducted on 60 patients aged between 1 and 10 years divided into two batches of 30 each. The first batch (LOT1) was represented by 30 oliguric patients, with a value of urinary specific gravity (USG) >1.055, an acidic pH and a urinary protein/creatinine ratio (UPC) >0.2, and the second batch (LOT2) was represented by 30 polyuric patients, with a urinary specific gravity (USG) 1.035, a neutral or alkaline pH and a urinary protein/creatinine ratio (UPC) 0.2 or borderline (0.2-0.4). In the first batch (LOT1), alkaline water without sodium and potassium, was administered. The water was based on a salt free formula with a pH of 8.0 and 10 ppm of potassium. In the second batch (LOT2), a neutral water with potassium was used. The water was based on a formula with salts (magnesium citrate, calcium acetate and sodium bicarbonate), with a pH of 7.0 and 12.5 ppm potassium. In both batches, the evaluation of the USG, the pH and the UPC was carried out for 180 days, at 30, 90 and 180 days. Hydration is an essential component in the management of patients diagnosed with feline urological syndrome. Administering an alkaline hydric diet in patients with aciduria is a solution to counteract the effect of metabolism on urinary pH. Potassium supplementation in polyuric patients is a beneficial solution in hypokalemia therapy. Potassium restriction in oliguric patients is a beneficial solution in the therapy of hyperkalemia.
Effects of antioxidant treatment on cell differentiation in rabbit embryos
Authors:   USV Timisoara, Torda Iuliu , Spătaru Ioana-Irina ,   USV Timisoara, Boldura Oana-Maria ,   USV Timisoara, Lungu Bianca Cornelia ,   USV TIMISOARA, Marc Simona ,   USV Timisoara, Daniel Bratu , Otavă Gabriel , Huțu Ioan ,   USV Timisoara, Mircu Călin ,   USV Timisoara
Published: May 2024

The antioxidant coenzyme Q10 can influence the expression of genes involved in apoptosis and energy metabolism of oocytes and quercetin can improve oocyte maturation and early embryonic development. In this study, the gene expression of GATA6 and NANOG in rabbit embryos was assessed using the qRT-PCR reaction. The groups were: group A- control group (no treatment added), group B (hormonal treatment of superovulation, which included the administration of PMSG and hCG), group C (administration of quercitin) and group D (administration of Coenzyme Q10). Our results show that the expression of the two genes was different depending on both the stage of embryonic development and the treatment administered. The highest values of gene expression for GATA6 and NANOG were obtained in groups 2, 4, 7, 8 and 9, corresponding to morula and blastocyst stages. In addition to the fact that NANOG and GATA6 are factors that are involved in early embryonic development, we believe that the administration of extrapituitary gonadotropins and antioxidants contributed to the increase in gene expression.
La red social X como canal de difusión del Podcasting
Authors: Martin Nieto Rebeca , Díaz Lucena Antonio
Published: May 2024

La actualidad digital viene marcada por el protagonismo de los contenidos sonoros. Este texto aborda la relación entre plataformas de audio y redes sociales, centrándose en la comunicación y la interacción a través de X (Twitter). La vinculación entre redes y audio está escasamente investigada a pesar de la popularidad que están alcanzando los podcasts, especialmente entre el público joven que es, al mismo tiempo, gran consumidor de redes sociales. Este artículo pretende conocer las oportunidades que ofrecen las redes para la difusión de contenidos sonoros y la posible atracción de una audiencia potencial significativa. La relevancia de las redes sociales como espacios de encuentro para los oyentes es cada vez mayor: crean comunidades dinámicas y fomentan la interactividad. En este contexto, el objetivo es conocer cómo las principales plataformas de creación y distribución de audio en España utilizan X para publicitar sus contenidos y conectarse con su audiencia con un planteamiento metodológico cuantitativo, respaldado por una muestra amplia (33.584 tuits). Se concluye que las plataformas de audio que sacan provecho a las posibilidades de la red social, que coinciden con contenidos vinculados con el entretenimiento y los géneros conversacionales, generan mayor enganche y participación de la audiencia.
Promoviendo la igualdad de género (ODS 5) a través de la ficción audiovisual
Authors: Junguitu-Angulo Leire , Osuna-Acedo Sara
Published: May 2024

Esta investigación examina la segunda temporada de la serie infantojuvenil transmedia Irabazi Arte! en relación a la promoción del empoderamiento y la igualdad de género (Objetivo de Desarrollo Sostenible 5). Irabazi Arte!, emitida por la televisión pública vasca (EITB), está producida íntegramente en euskera y su argumento central es el fútbol femenino. A través de una metodología mixta, se analiza si en su universo transmedia se fomenta la igualdad de género, cómo lo hace y si tiene un potencial de influencia en su público infanto-juvenil. Se constata una representación cuantitativa y cualitativamente positiva del ODS 5. Esta narrativa transmedia se ajusta a las características de la generación Alpha y contribuye al avance hacia la igualdad de género desde la educomunicación, fomentado la igualdad en la generación Alpha.
Editorial — Across Borders: Questions, Practices and Performances
Authors: Hernan Luis , Cheatle Emma , Statica Iulia
Published: May 2024

The relationship between architecture and border studies is, rightly, at the forefront of many architectural scholars' minds, and has seen the inception of other publications, most notably  Angeliki Sioli, Nishat Awan and Kristopher Palagi’s edited collection Architecture of Resistance: Negotiating Borders through Spatial Practices (KU Leuven, forthcoming) and a special issue of Architecture and Culture, ‘Border Fictions’ edited by Mohamad Hafeda and Samuel Vardy (again forthcoming). We started putting together this issue of field on borders,  ‘Across Borders: Questions, Practices and Performances’, the first full collection on architecture and borders to be published, number by defining what we specifically meant by the notion of border. The conventional meaning, as the delineation of territory, has shaped our individual lives: the three of us have moved across borders, territories, communities and languages several times; we have crisscrossed our identities from the colonised Global South, the so called commonwealth colonised antipodes, the settler colonial North America, the (post)communist East of Europe.  We have experienced bBorders, as Prem Kumar Rajaram and Carl Grundy-Warr tell us, are not as neutral separation lines: but thethey creatione ofa distinction between centre and periphery, normal and exceptional, belonging and not belonging. Borders enact biopolitics, demarcating (and othering) not only identity but creating zones of exception, a jurisdictions in which bodies (racialised, gendered) can be disciplined and made to conform and cohere. We realised, as we continued our attempt tos of definedefining borders, that any understanding of the bordersthey  are is always entangled with other political concepts. The border is the logical consequence of the notion of the utopia that underlies the nation state. An ideal place can only be created if it is set against the other, or its dystopia; the creation of, if there are  boundaries, physical or artificial, which make sure that the conditions for the ideal (and the non) place are maintained. Borders, are at once whether material and metaphorical, ; are always at once utopian, colonial, patriarchal, capitalist and hegemonic, 
Evaluation of Thermal and Drying Characteristics of Dried Hazelnut (Corylus avellana L.) Shell Waste
Authors:   Department of Mechanical Engineering, Namık Kemal University, Tekirdağ/Turkey, Moralar Aytac , Celen Soner
Published: May 2024

As a biomass fuel, the hazelnut shell must be milled into sawdust and dried to contain a certain amount of moisture. For this purpose, calorific value, drying rates, thermal values, moisture diffusion, activation energy, and energy consumption at the end of the drying of the hazelnut shell, which is dried in the conveyor belt and microwave dryer, were calculated. The total minimum energy consumed by the hazelnut shell at the end of the experiment in microwave drying was measured as 0.2 kWh for 460 W and 4.65 kWh at 80°C drying temperature in conveyor belt drying until the final moisture value reached 1.1±0.8% wet basis at the end of the experiment. The effective diffusivity of moisture of hazelnut shell changed from 4.13×10-7 to 1.89×10-6 m2 s-1, and the activation energy was found as 2.275 W g-1 in microwave drying. The effective diffusivity of moisture of hazelnut shell changed from 6.39×10-7 to 9.21×10-7 m2 s-1, and the activation energy was found as 19 kJ / mol in the conveyor belt drying. In general, the diffusion coefficient increased with increasing air temperature and decreased with increasing microwave power. At the end of the experiments, the temperature in the product was measured as 72°C in microwave drying and 73.5°C in conveyor belt drying. According to these values, it has been determined that the most suitable drying system for waste disposal was the microwave drying system. The calorific value was measured as 20028.52 kJ/kg in conveyor belt drying and 20036.76 kJ/kg in microwave drying. Microwave drying yielded better results with an increase of 2.72%.
The energy saving potential of using adaptive setpoint temperatures: a case study for offices in India
Authors:   Department of Electrical Engineering, University Carlos III of Madrid, Madrid, Spain, Sánchez-García Daniel , Bienvenido-Huertas David ,   Department of Building Constructions, University of Granada, Granada, Spain, Rubio-Bellido Carlos ,   Department of Building Constructions II, University of Seville, Seville, Spain
Published: May 2024

Adopting setpoint temperatures guided by adaptive thermal comfort models offers an efficient approach to conserving energy. Current research gives consideration to global models like ASHRAE Standard 55 and EN16798-1, which incorporate adaptive setpoint temperatures. However, this study follows a distinct path by incorporating a localized Indian adaptive comfort model, specifically the India Model for Adaptive Comfort for Commercial buildings (IMAC-C). This research delves into the energy-saving potential linked to the utilization of setpoint temperatures derived from IMAC-C. A comparative analysis is conducted, juxtaposing these temperatures with those based on the worldwide ASHRAE Standard 55 adaptive model and PMV-based setpoint temperatures aligned with the National Building Code for India. Comprehensive building energy simulations have been executed, encompassing all of India's climate zones and accommodating both naturally-ventilated and full air conditioning operational modes for buildings. The outcomes highlight that applying setpoint temperatures grounded in the IMAC-C adaptive comfort model in full air-conditioning mode could potentially lead to energy savings ranging between 9% and 26% in most of the climates. Consequently, it is conclusively determined that the integration of setpoint temperatures rooted in the Indian local adaptive comfort model represents a highly effective strategy for achieving energy conservation.
Pitch to policy program in India and Indonesia - a co-creation approach towards decarbonisation
Authors:   Faculty of Art, Design and Architecture, Monash University, Melbourne, Australia, Graham Peter , Burton Craig ,   Faculty of Art, Design and Architecture, Monash University, Melbourne, Australia, Seligmann Ari ,   Faculty of Art, Design and Architecture, Monash University, Melbourne, Australia
Published: May 2024

Across the world the building and construction sector contributes 37% of energy use and 39% of energy and process related carbon emissions. In order to keep global warming below 1.5 °C the buildings sector must halve its emissions by 2030 and be net-zero by 2050, yet emissions were their highest ever in 2021 because rates of new construction and increases in energy demand were far greater than efficiency gains delivered by new building regulations and other policy reforms. Global Buildings Performance Network (GBPN) and Monash University Australia conceived and implemented the Pitch to Policy (P>P) programme as an innovative experiment aimed at validating crowdsourcing, co-creation and systems thinking approaches to promote inclusive policy making for climate action. The program brought relevant government departments, policy makers and entrepreneurs together to co-create innovative solutions for decarbonizing the buildings sector. The program was piloted in two growing economies - India and Indonesia, in partnership with local organisations. A total of 25 teams of professionals participated in the program and 6 finalist teams were awarded seed funding. Some teams have gone on to win contracts, initiate important industry efforts and trial their inventions. Future work will build on post-P>P government engagement for winning teams.
Enhancing indoor air quality and occupant well-being in Split Air-conditioned bedrooms through integrated ventilation
Authors:   IIT Kharagpur, Kharagpur, India, Mondal Nilabhra , Nair Ajith ,   IIT Kharagpur, Kharagpur, India, Panicker Krithika ,   IIT Kharagpur, Kharagpur, India, Anand Prashant ,   IIT Kharagpur, Kharagpur, India, Mahdavi Ardeshir ,   TU Graz, Graz, Austria
Published: May 2024

Maintaining Indoor Air Quality (IAQ) and ensuring the well-being of individuals in split air-conditioned indoor spaces such as bedrooms can be challenging, primarily due to the increased risk of airborne infection transmission and high CO2 concentration. To address these issues, pertinent guidelines recommend ensuring adequate ventilation with fresh air, as it effectively mitigates the spread of indoor pollutants. However, split air-conditioned spaces often lack a continuous supply of fresh air. The resulting indoor air quality deterioration can cause occupants to resort to opening doors and windows. This, in turn, can result in an unnecessary increase in heating or cooling energy use. The objective of this study is to address the limitations of existing air cleaning and air- conditioning systems, which may include insufficient ventilation, excessive recirculation of indoor air, limited effectiveness, and the inability to dynamically respond to indoor pollutants in an energy-efficient manner. It has been observed that occupant’s open doors and windows for fresh air ventilation in response to a feeling of stuffiness for a considerable fraction of the total operational hours of a split AC in a bedroom. The present study suggests that by integrating ventilation and air-conditioning in a coordinated manner, IAQ and hence occupants' well-being in bedrooms can be enhanced in an energy-efficient manner.
Perception of the impact of biophilia on the health and well-being of occupants in a hospital setting
Authors:   Dr Bhanuben Nanavati College of Architecture,Pune, India, Watwani Unati , Dhamankar Namrata ,   Dr Bhanuben Nanavati College of Architecture,Pune, India
Published: May 2024

Individual perceptions are essential while evaluating the well-being benefits of nature. This study predicted biophilia's influences on the occupant’s health and well-being in a building. The study was conducted in a healthcare building in the city of Pune- a case of a hospital designed on the principles of biophilia was taken such that a comparison of observation and perception of occupants was analyzed. A biophilic design framework developed by Kellert in 2008 was adopted and a questionnaire was prepared based on the elements and attributes present in the case building based on diligent on-site observation of the whole campus of the case hospital. The survey was conducted with the prepared questionnaire based on the elements and attributes present using a Likert scale of 1 to 5 based on dissatisfaction and satisfaction level where 1 stands for extremely dissatisfied and 5 is extremely satisfied. Perception of 100 occupants is taken by further dividing them into 3 main categories based on their nature and daily workflow, the inpatients; the outpatients and visitors; and the staff. Results reveal 57.7% of the staff,76 % of the outpatients, and 84.36% of the inpatients were satisfied with the presence of biophilic elements and attributes present in the campus and state having improved health and well-being, however, few attributes like connection to place, natural shapes, and form contain mixed reviews due to lack of understanding of the attribute. Also, the results state that each element and attribute are interlinked, and a group of attributes is such a form dividing them into 6 categories. Few recommendations have been made based on the elements and attributes for enhanced health benefits. Accordingly, the study recommends that with the successful implementation of biophilic design principles, hospital buildings can be transformed into healing places that will boost and bring many benefits to the occupant’s health and well-being.
PREFERENCE OF INNOVATIVE AND TECHNOLOGICAL INTEGRATION OF MUTUAL FUND INVESTMENT TO THE INVESTOR IN THE CHENNAI CITY
Authors:   Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai, India, M Sriram , Devi Kabirdoss ,   Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai, India
Published: May 2024

In today's investment landscape, the infusion of innovation and technology within mutual fund offerings has become increasingly indispensable, especially for investors in Chennai. This study aims to explore the preferences of Chennai-based investors towards innovative and technologically advanced mutual fund investment solutions. Through a comprehensive survey methodology, the research seeks to discern investor sentiments and expectations concerning the integration of technology in mutual fund platforms. Specifically, it investigates the extent to which investors prioritize user-friendly interfaces, personalized investment choices, and real-time tracking functionalities. By pinpointing these preferences, financial institutions and fund managers can tailor their offerings to meet the distinct requirements of Chennai investors, thus fostering heightened engagement and participation in the mutual fund market. This investigation underscores the imperative of embracing innovation to enrich the investor journey and propel mutual fund adoption in Chennai, addressing the evolving needs and expectations of investors in the digital era.
Driving under the influence of psychoactive substances.„Influence” an issue in judicial practice?
Authors:   Lawyer Mureș Bar, ROMANIA, Maior Dragoș Alexandru
Published: May 2024

"At the end of the 19th century, the punitive celebration disappears, punishment becomes the most hidden part of the criminal process, leaving the domain of everyday perception to enter in abstract consciousness," recorded Michel Foucault in his famous work "Discipline and Punish: The Birth of the Prison" (Foucault, 1997). Therefore, it tends to a change of paradigm, it is desired that the effectiveness of the punishment is not the product of its visible intensity, but of the high degree of certainty. Metamorphosed from a theatrical act (often violent and public) into an administrative act, hidden from the eyes of citizens, criminal policy had to be adapted to encompass the new valence of the act of justice. One of the main means of punitive efficiency by referring to the abstract consciousness is that of the punishment limits that the legislator adjusts according to the criminal phenomenon, aiming both at an inhibitory, repressive and educational effect. It has often been assumed that the criminal recrudescence is due to low sentencing limits, and thus increasing the sentencing limits has been considered to fight all crime, omitting the adaptation of the entire legal norm to contemporary realities. Even the judicial act was not spared from this approach, although the scientific processes evolved and the probation together with them, in the face of a rigid legal norm, the judicial practice refuses to adapt to the new reality. Against the background of a national hysteria due to the scourge of drugs, legal arguments take precedence over scientific arguments.
Nurturing Resilience: Exploring the Interplay of Burnout, Turnover Intentions, and Professional Quality of Life among Female Nurses in Wah Cantt’s Hospitals
Authors: Adnan Haleem , Fatima Kaneez , Hassan Amna
Published: May 2024

The purpose of this study was to determine the associations between burnout, intention to leave, and professional quality of life among female nurses working in various Wah Cantt hospitals in Islamabad. The current study looked at the connection between female nurses' professional quality of life and their intention to leave burnout. Two hundred female nurses made up the sample, and information was gathered from hospitals in Wah Cantt. The information was gathered from several hospitals, both public and private. Of them, 73 belonged to private hospitals, and 127 were affiliated with government institutions. The age range of female nurses was 21 to 49 years old. Three measures are employed in this study: burnout, intention to leave, and professional quality of life. With the aid of SPSS software, the data was analysed using correlation, one-way ANOVA, independent t-tests, demographic variable frequencies, and regression analysis. For example, the BOS scale showed reliability (.697) when used to assess burnout, the TIS scale demonstrated reliability (.513) when used to assess turnover intention, and the proQoL scale demonstrated reliability (.671) when used to assess the professional quality of life among female nurses. The results showed that while there is a somewhat favourable correlation between burnout and proQoL, there is no significant correlation between burnout and turnover intention. Conversely, among nurses, there is a positive correlation between turnover intention and proQoL.
Analyzing the Israel-Palestine Conflicts: Assessing the Impact and Effectiveness of the Involvement of Islamic Countries
Authors: Ashraf Muhammad , Baqi Abdul
Published: May 2024

With their intricate political, theological, and practical complexities, the Israel-Palestine conflicts have persisted as one of the longest-lasting and most intricate geopolitical wars. This research explores the complex dynamics of the conflicts, concentrating on the role that Islamic countries have played. In the context of an ongoing and ambiguous dispute, this investigation aims to analyze the provocations, tactics, and influence of Islamic countries in determining the trajectory of the Israel-Palestine conflicts. The study defines the necessity for a focused discourse on the role of Islamic countries and points out gaps in existing research through a thorough literature review and a detailed analysis of literal and contemporary elements. The investigation items comprise an analysis of the provocation that led Islamic countries to participate in the wars, a review of the tactics used in the military, political, and economic spheres, a study of the influence on peacekeeping efforts, and a list of the obstacles and constraints that these countries had to deal with. The theoretical framework analyzes the actions and viewpoints of Islamic nations in the context of the Israel-Palestine disputes by drawing on transnational relations theories such as constructivism, literalism, and leftism.
Communication Protocols and Technologies for Multimedia Transmission: A Comprehensive Study
Authors:   Multimedia Engineering Department, Hannam University, Daejeon, South Korea, Islam Md. Rakibul
Published: May 2024

The exponential growth in end-user demand for multimedia content has necessitated significant advancements in communication technologies and multimedia processing. This paper presents a comprehensive review of various multimedia communication systems, focusing on the techniques employed for processing multimedia content and ensuring seamless transmission. It examines various technologies and communication protocols used to transport multimedia material while also addressing the difficulties these technologies present. The goal is to satisfy the growing demands for multimedia communication that include high data rates, wide bandwidth, low latency, and increased Quality of Service (QoS).
Remimazolam in pediatric surgery under general anesthesia: a case series
Authors: Shon Hong-Sik , Park Seyeon , Yoon Jung-Pil , Yoo Yeong Min , Lee Jimin , Lee Da Eun , Kim Hee Young
Published: May 2024

Remimazolam is a promising drug for general anesthesia due to its rapid onset, short duration, and short context-sensitive half-life. However, its use in pediatric patients remains off-label, and limited prospective data have been published. Herein, we report successful anesthesia using remimazolam in pediatric patients who had a history of epilepsy or required shared airway surgery. In all cases, remimazolam provided general anesthesia, and flumazenil was used for reversal with rapid recovery. Remimazolam offers advantages for pediatric anesthesia in scenarios with a risk of seizure or shared airway surgery. However, the potential for higher bispectral index values and the risk of anaphylaxis in dextran-allergic patients necessitate caution and further research.
This Movement Will Take You So High and So Low
Authors: Dawson Mia Karisa
Published: May 2024

I address this letter to myself on November 25, 2014, the day after the non-indictment of Michael Brown’s murderer, when a resounding silence in my college physics class sparked a fire in me and a journey of awakening and action. Somewhere between a love letter and a condolence, a reassurance and a forewarning, these words serve to soften my stumble towards empowerment and insight as I grow as a young organizer in the Black Lives Matter movement.
Identification of key factors for the successful development of agricultural biogas plants in Poland
Authors: Ginda Grzegorz , Szyba Marta
Published: May 2024

In Poland, the potential for biogas production is high. important source of renewable energy and contributes to reducing the emissions of methane, a greenhouse gas. In this article, based on materials from the National Agricultural Advisory Centre (KOWR), literature, and statistical data, the implementation of the agrigas plant construction programme was evaluated in individual voivodeships. Based on the collected data, it was concluded that the most meaningful factors for the successful development of Polish agricultural biogas plants are biogas production technology, substrate availability, energy price from renewable energy sources, waste disposal costs, population density in the commune, and allocation of places in local spatial development plans (MPZP). DEMATEL technique was used to identify key development factors. The results of the study provide useful information for both government and local authorities in the search for effective ways to drive the sector's development.
Reconstruction of simplex structures based on phase synchronization dynamics
Authors: Luo Kai-Ming , Guan Shu-Guang , Zou Yong ,   School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China
Published: May 2024

High-order interactions as exemplified by simplex and hyper-edge structures have emerged as a prominent area of interest in complex network research. These high-order interactions introduce much complexity into the interplay between nodes, which often require advanced analytical approaches to fully characterize the underlying network structures. For example, methods based on statistical dependencies have been proposed to identify high-order structures from multi-variate time series. In this work, we reconstruct the simplex structures of a network based on synchronization dynamics between network nodes. More specifically, we construct a topological structure of network by examining the temporal synchronization of phase time series data derived from the Kuramoto-Sakaguchi (KS) model. In addition, we show that there is an analytical relationship between the Laplacian matrix of the network and phase variables of the linearized KS model. Our method identifies structural symmetric nodes within a network, which therefore builds a correlation between node synchronization behavior and network’s symmetry. This representation allows for identifying high-order network structure, showing its advantages over statistical methods. In addition, remote synchronization is a complex dynamical process, where spatially separated nodes within a network can synchronize their states despite the lack of direct interaction. Furthermore, through numerical simulations, we observe the strong correlation between remote synchronization among indirectly interacting nodes and the network’s underlying symmetry. This finding reveals the intricate relationship between network structure and the dynamical process. In summary, we propose a powerful tool for analyzing complex networks, in particular uncovering the interplay between network structure and dynamics. We provide novel insights for further exploring and understanding the high-order interactions and the underlying symmetry of complex networks.
Theoretical investigation of electron-impact ionization of W6+ ion
Authors: Ma Li-Li , Zhang Shi-Ping , Zhang Fang-Jun , Li Mai-Juan , Jiang Jun , Ding Xiao-Bin , Xie Lu-You , Zhang Deng-Hong , Dong Chen-Zhong ,   Key Laboratory of Atomic and Molecular Physics & Functional Materials of Gansu Province, College of Physics and Electronic Engineering, Northwest Normal University, Lanzhou 730070 China
Published: May 2024

Due to its unique characteristics, metal tungsten has been selected as the wall material for the tokamak magnetic confinement fusion device. The wall material directly interacts with the plasma for a long time, thus causing tungsten atoms and ions to be sputtered and ionized into different charge states, which then enter the tokamak device as plasma impurities. To ensure stable plasma combustion conditions, highly complex model is currently being used to evaluate the behavior of tungsten impurities and their influence on the tokamak plasma. This requires various high-precision atomic data for tungsten atoms and different ionized states of tungsten ions. Electron collision ionization, as a fundamental atomic physical process, is widely encountered in laboratory and astrophysical plasma environments. The parameters such as electron collision ionization cross-sections and rate coefficients are crucial for plasma radiation transport simulations and state diagnostics.

Electron-impact single-ionization (EISI) cross sections of the ground state and metastable state for W6+ ions are calculated by using the level-to-level distorted-wave (LLDW) method. The contributions of direct ionization (DI) cross section and excited autoionization (EA) cross section to the total EISI cross section are primarily considered.

Comparison of our calculation results with the experimental data from Stenke et al. (Stenke M, Aichele K, Harthiramani D, Hofmann G, Steidl M, Volpel R, Salzborn E 1995 J. Phys. B: At. Mol. Opt. Phys. 28 2711) reveals that the EISI cross section considering only the ground state is significantly smaller than the experimental result. Therefore, it is imperative to take into account the contribution from the metastable state. To determine the fraction of ions in long-lived energy levels within the parent ion beam, three models are employed.

Our results, which include the contribution of metastable states, accord well with the experimental results of Stenke et al. Compared with the theoretical calculation result of Pindzola et al. our calculaiton provides a more comprehensive understanding of the electron-impact single-ionization process for W6+ ions. The comparison is illustrated in the attached figure.
Large-scale deorphanization of Nematostella vectensis neuropeptide G protein-coupled receptors supports the independent expansion of bilaterian and cnidarian peptidergic systems
Authors: Thiel Daniel , Yañez Guerra Luis Alfonso , Kieswetter Amanda , Cole Alison G , Temmerman Liesbet , Technau Ulrich , Jékely Gáspár
Published: May 2024

Neuropeptides are ancient signaling molecules in animals but only few peptide receptors are known outside bilaterians. Cnidarians possess a large number of G protein-coupled receptors (GPCRs) – the most common receptors of bilaterian neuropeptides – but most of these remain orphan with no known ligands. We searched for neuropeptides in the sea anemone Nematostella vectensis and created a library of 64 peptides derived from 33 precursors. In a large-scale pharmacological screen with these peptides and 161 N. vectensis GPCRs, we identified 31 receptors specifically activated by 1 to 3 of 14 peptides. Mapping GPCR and neuropeptide expression to single-cell sequencing data revealed how cnidarian tissues are extensively connected by multilayer peptidergic networks. Phylogenetic analysis identified no direct orthology to bilaterian peptidergic systems and supports the independent expansion of neuropeptide signaling in cnidarians from a few ancestral peptide-receptor pairs.
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages
Authors: Bates Timothy A , Trank-Greene Mila , Nguyenla Xammy , Anastas Aidan , Gurmessa Sintayehu K , Merutka Ilaria R , Dixon Shandee D , Shumate Anthony , Groncki Abigail R , Parson Matthew AH , Ingram Jessica R , Barklis Eric , Burke John E , Shinde Ujwal , Ploegh Hidde L , Tafesse Fikadu G
Published: May 2024

Mycobacterium tuberculosis
(Mtb) is known to survive within macrophages by compromising the integrity of the phagosomal compartment in which it resides. This activity primarily relies on the ESX-1 secretion system, predominantly involving the protein duo ESAT-6 and CFP-10. CFP-10 likely acts as a chaperone, while ESAT-6 likely disrupts phagosomal membrane stability via a largely unknown mechanism. we employ a series of biochemical analyses, protein modeling techniques, and a novel ESAT-6-specific nanobody to gain insight into the ESAT-6’s mode of action. First, we measure the binding kinetics of the tight 1:1 complex formed by ESAT-6 and CFP-10 at neutral pH. Subsequently, we demonstrate a rapid self-association of ESAT-6 into large complexes under acidic conditions, leading to the identification of a stable tetrameric ESAT-6 species. Using molecular dynamics simulations, we pinpoint the most probable interaction interface. Furthermore, we show that cytoplasmic expression of an anti-ESAT-6 nanobody blocks Mtb replication, thereby underlining the pivotal role of ESAT-6 in intracellular survival. Together, these data suggest that ESAT-6 acts by a pH dependent mechanism to establish two-way communication between the cytoplasm and the Mtb-containing phagosome.
Shortcutting from self-motion signals reveals a cognitive map in mice
Authors: Xu Jiayun , Girardi-Schappo Mauricio , Beique Jean-Claude , Longtin André , Maler Leonard
Published: May 2024

Animals navigate by learning the spatial layout of their environment. We investigated spatial learning of mice in an open maze where food was hidden in one of a hundred holes. Mice leaving from a stable entrance learned to efficiently navigate to the food without the need for landmarks. We developed a quantitative framework to reveal how the mice estimate the food location based on analyses of trajectories and active hole checks. After learning, the computed ‘target estimation vector’ (TEV) closely approximated the mice’s route and its hole check distribution. The TEV required learning both the direction and distance of the start to food vector, and our data suggests that different learning dynamics underlie these estimates. We propose that the TEV can be precisely connected to the properties of hippocampal place cells. Finally, we provide the first demonstration that, after learning the location of two food sites, the mice took a shortcut between the sites, demonstrating that they had generated a cognitive map.
Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis
Authors: Kundu Suman , Shetty Advait , Gomes-Solecki Maria
Published: May 2024

Previous studies demonstrated that Leptospira biflexa, a saprophytic species, triggers innate immune responses in the host during early infection. This raised the question of whether these responses could suppress a subsequent challenge with pathogenic Leptospira. We inoculated C3H/HeJ mice with a single or a double dose of L. biflexa before challenge with a pathogenic serovar, Leptospira interrogans serovar Copenhageni FioCruz (LIC). Pre-challenge exposure to L. biflexa did not prevent LIC dissemination and colonization of the kidney. However, it rescued weight loss and mouse survival thereby mitigating disease severity. Unexpectedly, there was correlation between rescue of overall health (weight gain, higher survival, lower kidney fibrosis marker ColA1) and higher shedding of LIC in urine. This stood in contrast to the L. biflexa unexposed LIC challenged control. Immune responses were dominated by increased frequency of effector T helper (CD4+) cells in spleen, as well as significant increases in serologic IgG2a. Our findings suggest that exposure to live saprophytic Leptospira primes the host to develop Th1 biased immune responses that prevent severe disease induced by a subsequent challenge with a pathogenic species. Thus, mice exposed to live saprophytic Leptospira before facing a pathogenic serovar may withstand infection with far better outcomes. Furthermore, a status of homeostasis may have been reached after kidney colonization that helps LIC complete its enzootic cycle.
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Authors: Leclercq Sophie , Ahmed Hany , Amadieu Camille , Petit Géraldine , Koistinen Ville , Leyrolle Quentin , Poncin Marie , Stärkel Peter , Kok Eloise , Karhunen Pekka J , de Timary Philippe , Laye Sophie , Neyrinck Audrey M , Kärkkäinen Olli K , Hanhineva Kati , Delzenne Nathalie
Published: May 2024

Background:

Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promising approach to decipher metabolic events related to AUD. The plasma metabolome contains a plethora of bioactive molecules that reflects the functional changes in host metabolism but also the impact of the gut microbiome and nutritional habits.

Methods:

In this study, we investigated the impact of severe AUD (sAUD), and of a 3-week period of alcohol abstinence, on the blood metabolome (non-targeted LC-MS metabolomics analysis) in 96 sAUD patients hospitalized for alcohol withdrawal.

Results:

We found that the plasma levels of different lipids ((lyso)phosphatidylcholines, long-chain fatty acids), short-chain fatty acids (i.e. 3-hydroxyvaleric acid) and bile acids were altered in sAUD patients. In addition, several microbial metabolites, including indole-3-propionic acid, p-cresol sulfate, hippuric acid, pyrocatechol sulfate, and metabolites belonging to xanthine class (paraxanthine, theobromine and theophylline) were sensitive to alcohol exposure and alcohol withdrawal. 3-Hydroxyvaleric acid, caffeine metabolites (theobromine, paraxanthine, and theophylline) and microbial metabolites (hippuric acid and pyrocatechol sulfate) were correlated with anxiety, depression and alcohol craving. Metabolomics analysis in postmortem samples of frontal cortex and cerebrospinal fluid of those consuming a high level of alcohol revealed that those metabolites can be found also in brain tissue.

Conclusions:

Our data allow the identification of neuroactive metabolites, from interactions between food components and microbiota, which may represent new targets arising in the management of neuropsychiatric diseases such as sAUD.

Funding:

Gut2Behave project was initiated from ERA-NET NEURON network (Joint Transnational Call 2019) and was financed by Academy of Finland, French National Research Agency (ANR-19-NEUR-0003-03) and the Fonds de la Recherche Scientifique (FRS-FNRS; PINT-MULTI R.8013.19, Belgium). Metabolomics analysis of the TSDS samples was supported by grant from the Finnish Foundation for Alcohol Studies.