bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advances in the Synthesis of Cyclic Sulfone Compounds with Potential Biological Activity
Authors: Huang Hong-Li , Shi Ya-Qian , Ning Jia-Xin , Li Shan , Song Dian-Tao , Gao Fei , Ma Na
Published: December 2024

In recent years, cyclic sulfone compounds, a subset of biologically active heterocyclic compounds, have gained considerable attention due to their potential in the development of novel active pharmaceutical ingredients. This review focuses on identifying simple, mild, environmentally friendly, and efficient synthesis methods. Various catalytic approaches for the synthesis of cyclic sulfone compounds are systematically reviewed, highlighting their advantages and potential applications in pharmaceutical development.
Infrared Aircraft Detection Algorithm Based on High-Resolution Feature-Enhanced Semantic Segmentation Network
Authors: Liu Gang , Xi Jiangtao , Ma Chao , Chen Huixiang
Published: December 2024

In order to achieve infrared aircraft detection under interference conditions, this paper proposes an infrared aircraft detection algorithm based on high-resolution feature-enhanced semantic segmentation network. Firstly, the designed location attention mechanism is utilized to enhance the current-level feature map by obtaining correlation weights between pixels at different positions. Then, it is fused with the high-level feature map rich in semantic features to construct a location attention feature fusion network, thereby enhancing the representation capability of target features. Secondly, based on the idea of using dilated convolutions to expand the receptive field of feature maps, a hybrid atrous spatial pyramid pooling module is designed. By utilizing a serial structure of dilated convolutions with small dilation rates, this module addresses the issue of feature information loss when expanding the receptive field through dilated spatial pyramid pooling. It captures the contextual information of the target, further enhancing the target features. Finally, a dice loss function is introduced to calculate the overlap between the predicted results and the ground truth labels, facilitating deep excavation of foreground information for comprehensive learning of samples. This paper constructs an infrared aircraft detection algorithm based on a high-resolution feature-enhanced semantic segmentation network which combines the location attention feature fusion network, the hybrid atrous spatial pyramid pooling module, the dice loss function, and a network that maintains the resolution of feature maps. Experiments conducted on a self-built infrared dataset show that the proposed algorithm achieves a mean intersection over union (mIoU) of 92.74%, a mean pixel accuracy (mPA) of 96.34%, and a mean recall (MR) of 96.19%, all of which outperform classic segmentation algorithms such as DeepLabv3+, Segformer, HRNetv2, and DDRNet. This demonstrates that the proposed algorithm can achieve effective detection of infrared aircraft in the presence of interference.
Eye-Tracking Characteristics: Unveiling Trust Calibration States in Automated Supervisory Control Tasks
Authors: Wang Keran , Hou Wenjun , Ma Huiwen , Hong Leyi
Published: December 2024

Trust is a crucial human factor in automated supervisory control tasks. To attain appropriate reliance, the operator’s trust should be calibrated to reflect the system’s capabilities. This study utilized eye-tracking technology to explore novel approaches, given the intrusive, subjective, and sporadic characteristics of existing trust measurement methods. A real-world scenario of alarm state discrimination was simulated and used to collect eye-tracking data, real-time interaction data, system log data, and subjective trust scale values. In the data processing phase, a dynamic prediction model was hypothesized and verified to deduce and complete the absent scale data in the time series. Ultimately, through eye tracking, a discriminative regression model for trust calibration was developed using a two-layer Random Forest approach, showing effective performance. The findings indicate that this method may evaluate the trust calibration state of operators in human–agent collaborative teams within real-world settings, offering a novel approach to measuring trust calibration. Eye-tracking features, including saccade duration, fixation duration, and the saccade–fixation ratio, significantly impact the assessment of trust calibration status.
Characterization of the complete mitogenomic and phylogenetic of the Columba livia breed Şebap pigeon.
Authors: Çelik Romedi , Bilgen Nüket , Yiğin Akın , Gürler Şükrü , Bozkaya Faruk , Kutlu Furkan , Akkurt Mustafa Yenal
Published: December 2024

Gen kaynaklarının korunmasına odaklanan çalışmaların ilk aşaması, mevcut ırkların fenotipik ve genetik karakterizasyonunu içermektedir. Genetik analizler için oldukça uygun olan mitokondriyal DNA (mtDNA) seviyesindeki farklılıkların açıklanması, yerel ırklar arasında genetik mesafelerin hesaplanabilmesini, evrimsel analizler aracılığıyla potansiyel evcilleştirme merkezlerinin belirlenebilmesini ve ırklar arasındaki akrabalık ilişkilerini gösteren filogeni ağaçlarının oluşturulabilmesini mümkün kılar. Şanlıurfa, geleneksel güvercin yetiştiriciliğinin uzun bir geçmişe sahip olması ve güvercin evcilleştirmesi merkezlerinden biri olması nedeniyle güvercin yetiştiriciliğinde önem taşımaktadır. Bu çalışma, Şanlıurfa iline özgü güvercin ırklarından Şebap güvercinini tüm mtDNA dizisi açısından karakterize etmeyi amaçlamaktadır.
Şebap güvercininin mitokondriyal genomu, 17,232 bp boyutunda olup, 13 Protein-Kodlayan Gen (PCG), iki Ribozomal RNA (rRNA) ve 22 Transfer RNA (tRNA) içermektedir. Genel mitokondriyal genom kompozisyonu, sırasıyla %29.6 A, %24.5 T, %31.2 C ve %14.7 G içermekte olup, belirgin bir şekilde %54.1 A-T zenginliğine sahiptir. Özellikle, ND6 L zincirinde kodlanırken diğerleri H zincirinde kodlanmaktadır.
Research Data Management Policy
Authors:   Munster Technological University
Published: December 2024

The purpose of this policy is to provide a framework for Research Data Management (RDM) in the University throughout the stages of the research cycle. This includes, but is not limited to, collection, curation,secure storage, organisation, retrieval, re-use, sharing, archiving, and access of research data, in accordance with international best practice, legal, statutory, ethical, contractual and intellectual property obligations, and the requirements of research funding bodies, publishers and stakeholders.

The University and researchers will make all best efforts to make sure they are consistent with this policy.
Современная концепция хронической боли: обзор литературы (часть 1)
Authors: Наумовская Н.А. , Рушкевич Ю.Н. , Лихачев С.А.
Published: December 2024

В обзоре поднимаются вопросы хронической боли и ее компонентов. Хроническая боль является широко распространенной проблемой, оказывающей существенное негативное влияние на пациента, его семью и общество. До 80% пациентов с хронической болью не удовлетворены результатами терапии и заявляют о значительном снижении качества жизни. Боль является итогом взаимодействия ноцицептивной и антиноцицептивной систем. На формирование индивидуального ощущения боли как страдания оказывают влияние не только биологические факторы, такие как характер повреждения, пол, возраст и генетические особенности, определяющие болевую реакцию. Большое значение имеют психологические и социальные характеристики пациента, поэтому в настоящий момент боль рассматривается в рамках биопсихосоциальной модели. Для успешной коррекции болевого синдрома специалисту необходимо понимать механизмы формирования ноцицептивной, невропатической и ноципластической (дисфункциональной) боли и уметь определять представленность этих компонентов в составе смешанной хронической боли. Отдельное внимание в обзоре уделяется способам выявления дисфункционального компонента боли, а также обсуждению протоколов лечения и нерешенных вопросов коррекции фармакорезистентных невропатических болевых синдромов в Республике Беларусь и мире.

The review highlights issues of chronic pain and its components. Chronic pain is a widespread issue having a significant negative impact on patients, their families and the society as a whole. Up to 80% of patients with chronic pain are not satisfied with therapy outcomes and report a substantial decline in their quality of life. The pain is the result of an interaction between the nociceptive and antinociceptive systems. The pain sensation as an individual suffering experience is shaped by not only biological factors, such as damage pattern, sex, age and genetic characteristics, determining pain response, also by both psychological and social factors To successfully correct pain syndrome, professionals need to understand mechanisms underlying nociceptive, neuropathic and nociplastic (dysfunctional) pain, and they should be able to identify these components within mixed chronic pain. The review pays particular attention to the ways of detecting the dysfunctional component of pain, and discusses treatment protocols and unresolved issues of managing pharmacoresistant neuropathic pain syndromes in the Republic of Belarus and worldwide.
Селективная дорзальная ризотомия в лечении спастического синдрома у взрослых (обзор литературы). Часть 2: дооперационное планирование, интраоперационная нейрофизиологическая диагностика и хирургические методики, эффективность и послеоперационные осложнения*
Authors: Забродец Г.В. , Рушкевич Ю.Н. , Талабаев М.В. , Василевич Э.Н.
Published: December 2024

Цель. Изучить общие принципы селективной дорзальной ризотомии (СДР), подходы к выбору оптимальной хирургической техники и интраоперационного нейрофизиологического мониторинга на основании современных научных данных для информирования широкого круга специалистов, занимающихся проблемой спастичности. Результаты. На основании обзора литературных данных изложены основные существующие хирургические техники СДР. Описаны различные подходы к выполнению интраоперационной нейрофизиологической диагностики корешковых структур. Проведен анализ основных опубликованных данных по эффективности лечения спастичности при различной патологии у взрослых методом СДР, возможных послеоперационных осложнений. Заключение. Выполнение СДР у взрослых пациентов является перспективным методом коррекции спастического синдрома. Для получения достоверных данных о результатах СДР требуется применение единых подходов к до- и послеоперационной оценке функциональных нарушений, набор большего количества пациентов одной этиологии и схожих возрастных групп.

Purpose. To study general principles of selective dorsal rhizotomy (SDR), approaches to selecting an optimal surgical techniques and intraoperative neurophysiologic monitoring based on current scientific evidence to inform a wide range of specialists dealing with spasticity. Results. Based on a literature review, the main available surgical techniques for SDR are outlined. Different approaches to intraoperative neurophysiologic diagnostics of radicular structures are described. The main published data on the efficacy of spasticity treatment in various pathologies in adults by SDR method, as well as potential postoperative complications, were analyzed. Conclusion. Performing SDR in adult patients is a promising method for spasticity correction. To obtain reliable data on SDR outcomes unified approaches to pre- and postoperative assessment of functional disorders, as well as enrollment of a larger number of patients of similar etiology and age groups are required.
Первичная прогрессирующая апраксия речи – редкий синдром фокальных корковых дегенераций: клиническое наблюдение
Authors: Ализаде Х.И. , Невзорова К.В. , Ахмадуллина Д.Р. , Бердникович Е.С. , Шпилюкова Ю.А. , Федотова Е.Ю.
Published: December 2024

Первичная прогрессирующая апраксия речи – редкое моторное расстройство речи, проявляющееся неуклонным прогрессированием речевых расстройств при отсутствии в клинической картине других неврологических симптомов, входящее в группу фокальных нейродегенераций. С учетом нередко малозаметного дебюта и отсутствия общепринятых критериев диагностики своевременное выявление данного синдрома вызывает определенные трудности. В данной статье представлено описание редкого клинического наблюдения пациента с первичной прогрессирующей апраксией речи с прогрессированием в кортикобазальный синдром, демонстрирующий сложности диагностики и дифференциального диагноза с близкими по патогенезу нейродегенеративными расстройствами. Выявление особенностей речевых нарушений с помощью подробного нейропсихологического и логопедического обследований, а также данные нейровизуализации играют существенную роль в установлении нозологического диагноза с целью определения прогноза заболевания и выбора терапевтической тактики.

Primary progressive apraxia of speech is a rare motor speech disorder characterized by steady progression of speech impairments in absence of other neurological symptoms. It belongs to the group of focal neurodegenerations. Taking into account subtle onset of disease and absence of conventional diagnostic criteria, timely diagnosis of this syndrome is challenging. A rare clinical case of a patient with primary progressive apraxia of speech progressing into corticobasal syndrome is presented in this article, thus demonstrating challenges in diagnosing and differentiation in neurodegenerative disorders with similar pathogenesis. The identification of specifics of speech impairment using thorough neuropsychological and logopedic evaluations, as well as neuroimaging play a pivotal role in nosological diagnosing, predicting the disease outcomes, and selecting therapeutic strategies.
Ambulante Pädiatrische Palliative Care - Ein praktischer Leitfaden für Schweizer Praxispädiater:innen, Kinderspitexen, Kinderhospize und Langzeitinstitutionen
Authors: Ogal Mercedes , Keller Simone , Buder Regula , Truttmann Vreni , Höss Martin , Brenninkmeijer Elisabeth , Liechti Cathrine , Bucher Andrea
Published: December 2024

Als praktischer Leitfaden in der ambulanten Betreuung von Kindern mit potenziell lebensverkürzenden Krankheiten und ihren Familien dient dieser Artikel dem Wissenszuwachs sowie Kennenlernen von Ressourcen und Angeboten der pädiatrische Palliative Care, damit der Aufbau eines tragenden Betreuungsnetzes für die Familie gelingt. Durch das Wissen um die möglichen Angebote können Synergien und Ressourcen unter den Leistungserbringern besser genutzt werden.
Trauerbegleitung stärkt Kinder und ihre Familien
Authors: Honegger Rachel , Frei Riccarda , Abbruzzese Monteagudo Rosanna
Published: December 2024

Trauer ist keine Krankheit - Nein, Trauer ist eine natürliche, seelische und zuweilen auch körperliche Reaktion auf einen Verlust. Allerdings kann verdrängte oder nicht durchlebte Trauer tatsächlich krank machen. Deswegen ist es wichtig, dass der Trauer Raum gegeben wird, auch bereits in palliativen Situationen.
Jugendlichen ihre schlechte Prognose eröffnen: rechtliche und ethische Herausforderungen bei der Aufklärung
Authors: Le Bourgeois Fleur , Lipp Alexandra , Jürgen Jox Ralf , Droz-Sauthier Gaëlle
Published: December 2024

James ist ein 14-jähriger Jugendlicher und seit drei Jahren wegen eines Gehirntumors beim pädiatrischen Onkologie-Team eines Universitätsspitals in Behandlung. Zum Diagnosezeitpunkt war der Tumor in einem niedrigen Stadium, und James hat mehrere wachstumshemmende onkologische Behandlungen (Bestrahlung und Chemotherapie) erhalten. Er kommt regelmässig zur klinisch-radiologischen Verlaufskontrolle.
Krankheit und Tod im Familiensystem: Sozialversicherungsrechtliche und psychosoziale Aspekte der Sozialberatung
Authors: Tschudi Nora , Fronterotta Linda
Published: December 2024

Die Diagnose einer lebensverkürzenden Erkrankung eines Kindes stellt das Leben einer Familie vor unerwartete Herausforderungen. Unvorbereitet verändert sich ihr Alltag und nicht selten müssen Eltern sich von beabsichtigten Lebensplänen verabschieden. Dies verlangt von Familien enorme Anpassungsleistungen sowie persönliche, materielle und soziale Ressourcen. Kinder mit Palliative-Bedarf stellen daher nicht nur Fachpersonen vor Herausforderungen, sondern vor allem auch die Eltern und die Geschwister. Der folgende Beitrag beleuchtet anhand verschiedener Fallbeispiele die unterschiedlichen psychosozialen und sozialarbeiterischen Aspekte rund um das Thema Krankheit und Tod im Familiensystem.
Das nationale Netzwerk für Pädiatrische Palliative Care (PPCN CH) – ein schweizweites Engagement von und für Fachpersonen
Authors: Gubler Deborah , Mackuth Cornelia
Published: December 2024

Kinder und Jugendliche mit komplexen chronischen Erkrankungen, bei denen ein kurativer Behandlungsansatz nicht (mehr) zielführend oder der Nutzen unsicher ist, bedürfen einer umfassenden palliativen Betreuung, welche die Familie und ihr Umfeld eng berücksichtigt. Diese kann medizinisch-pflegerischer und/oder sozialer, seelischer und/oder spiritueller Art sein. Nahestehende, insbesondere Eltern, Geschwister, Grosseltern und andere Bezugspersonen sind mitbetroffen – über das Versterben des Kindes oder des Jugendlichen hinaus.
Soins palliatifs en pédiatrie – où en sommes-nous ? où va-t-on ?
Authors: Bergsträsser Eva , Streuli Jürg C.
Published: December 2024

Les soins palliatifs pour enfants et adolescent·e·s se sont établis dans les pays disposant d’un système de santé de bonne qualité. L’offre ne profite cependant de loin pas à tous les enfants et familles qui pourraient en profiter – en Suisse nous atteignons à peine 10% des enfants qui nécessitent des soins palliatifs.
Soins palliatifs pédiatriques ambulatoires – un guide pratique pour la pédiatrie, les soins pédiatriques à domicile, hospices et institutions de soins de longue durée
Authors: Ogal Mercedes , Keller Simone , Bender Regula , Truttmann Vreni , Höss Martin , Brenninkmeijer Elisabeth , Liechti Cathrine , Bucher Andrea
Published: December 2024

Ce guide pratique, destiné à la prise en charge ambulatoire d’enfants et de leur familles avec des maladies pouvant limiter l’espérance de vie , souhaite améliorer les notions et faire connaître les ressources et offres de soins palliatifs pédiatriques, afin de réussir à développer un réseau de soins efficace pour les familles. La connaissance des offres disponibles permet de mieux utiliser les synergies et ressources entre les différents prestataires.
La maîtrise de symptômes dans les soins palliatifs pédiatriques – notions intéressantes et utiles
Authors: Süess Erika , Ogal Mercedes , Bender Hans-Ulrich , Bergsträsser Eva
Published: December 2024

Le traitement de symptômes lourds et pénibles est le pilier des soins palliatifs pédiatriques (SPP). Dans cette contribution sont présentés quelques-uns des symptômes pénibles les plus fréquents et les options thérapeutiques.
Le réseau national pour soins palliatifs pédiatriques (PPCN CH) – un engagement suisse par et pour les professionnel·le·s
Authors: Gubler Deborah , Mackuth Cornelia
Published: December 2024

Les enfants et les adolescent·e·s atteint·e·s d’une maladie chronique complexe, pour laquelle une approche curative n'est pas ou n’est plus efficace ou dont le bénéfice est incertain, nécessitent une prise en charge palliative globale, qui prend en compte la famille et son entourage. L’approche peut être médicale et soignante et/ou sociale, psychologique et/ou spirituelle. Les proches, en particulier les parents, les frères et sœurs, les grands-parents et d'autres personnes de référence, sont également touchés, même au-delà du décès de l'enfant ou de l'adolescent·e.
Seakeeping performance prediction of a river-costal boat made of GRE composite materials
Authors: Perijoc Dumitru-Silviu , Domnișoru Leonard
Published: December 2024

The design of the river-costal vehicles imposes the assessment by several hydrodynamic and structural criteria. This research involves the evaluation of a river-costal boat made of GRE composite materials at full load condition. The boat’s navigation area covers the Danube in land and costal zones, modeled as irregular oblique waves. The analysis is based on a strip theory hydrodynamic approach and short-term statistical dynamic response approach, delivering the seakeeping performances prediction of the river-costal boat.
On the structural analysis by a midship cargo-holds model of an oil tanker 105930 dwt
Authors: Bilea-Pricop Andreea , Domnișoru Leonard
Published: December 2024

This paper aims to analyze global-local structural analysis using a model with three tanks in the central area of an oil tanker. Taking into account the negative effects of petroleum cargo on marine fauna and flora, regulations have been imposed on the reduction of pollution of the marine environment, thus, the stresses and deformations state of tanker vessels is an aspect of great interest in the design phase. Also, the paper captures the influence of the navigation conditions on the structure of the ship's hull and the effect that sloshing in cargo tanks has on the inner hull.
The reduction of the main engine’s power for a 15000 tdw chemical tanker regarding the achievement of EEXI and its influence on manoeuverability
Authors: Paun Iulia Andreea , Bosoancă Radu
Published: December 2024

EEXI was established as a measure for assessing the energy efficiency of existing vessels and aims to reduce CO2 in order to achieve IMO regulations. The purpose of this study is to calculate the EEXI for a 15000 twd chemical tanker and further evaluate the impact of this change on ship manoeuvrability. EEXI estimations were conducted using different approaches while manoeuvrability performances were evaluated by means of different simulation programs. The purpose of this study revolves around striking a balance between optimal operation and achieving energy efficiency.
Securing innovation at sea: Cyber risk management for SMEs in ship design
Authors: Ungureanu Mirela-Alexandra , Gavan Eugen , Gasparotti Carmen
Published: December 2024

This paper examines the critical cybersecurity landscape faced by maritime SMEs engaged in Ship Design, analysing their vulnerability to various cyber threats including ransomware, phishing attacks, and supply chain compromises. Through a comprehensive review of recent industry reports, regulatory frameworks, and cybersecurity incidents, we identify key risk factors and assess their potential impact on SMEs' operations, reputation, and competitive advantage. Our analysis reveals that maritime SMEs face disproportionate challenges in cybersecurity due to resource constraints, complex supply chain relationships, and the increasing sophistication of cyber threats targeting intellectual property. The paper presents a structured approach to cyber risk management based on established frameworks, emphasizing the protection of valuable intellectual property while maintaining operational efficiency. We propose practical recommendations for implementing robust cybersecurity measures within the resource constraints typical of SMEs, including strategies for threat detection, incident response, and recovery planning.
On a river-barge numerical strength analysis in head design wave loads
Authors: Mihalcea Adriana-Alina , Rusu Liliana-Celia , Domnișoru Leonard
Published: December 2024

The FEM approach is a well-established computational technique for solving the governing equations of structural mechanics under various loadings. To delve deeper into the FEM approach, we focus on the floating structure of a river barge. This study aims to determine a structure's structural capacity by applying admissible stress criteria following the DNV rules. The structural analysis involves a comparative study of stress levels from the equivalent design wave loads for two river-barge operational conditions, light, and full cargo cases.
The influence of the constructive shapes of aluminum profiles on impact phenomena
Authors: Popescu Gabriel
Published: December 2024

The purpose of this study is to analyze the results obtained from the impact for aluminum profiles in four constructive variants, two with connections and two with bevels.The forms significantly influence the results from a quantitative and qualitative point of view, making it possible to recommend the choice of the type of profile.
Research competencies to designers: A systematic literature review
Authors: Rivera-Gutiérrez Erika , Higuera-Zimbron Alejandro , Arguello Georgina
Published: December 2024

The study entitled Research Competencies for Designers: A Systematic Review aims to determine the fundamental research competencies for the training of designers and their impact in the professional field. By outlining and establishing them, the aim is to optimize the training process in Design programs, training
students to become innovative professionals and leaders in their respective areas of specialization. The research is based on a comprehensive review of the scientific literature, analyzing recent studies from various specialized databases, both in the field of Design and in higher education—the methodological approach, is a
systematic review that explores a specific educational phenomenon from multiple perspectives. The results reveal deficiencies in certain key competencies, such as the ability to evaluate the state of the art in research and the skills to communicate findings effectively. Despite these shortcomings, opportunities and challenges are identified that allow progress in research training. The study provides a solid framework for future research, underlining the crucial importance of research competencies in academic success, student retention, and professional preparation of designers. These skills are considered an essential factor in strengthening the quality of training and in facing the challenges of the contemporary work environment.
University student skill’s monitoring system
Authors: Montecillo-Puente Francisco Javier , Cruz-Loera María de la Luz , Lara-Rivera Agustin
Published: December 2024

Job collocation is a great challenge for professionals; companies look for profiles with skills and verifiable work experience. Univesities and Education Institutions have this great responsibility. Mechanisms they have to develop skills are: educational program, professional practices and thesis. This work is aimed at determining the skills that students of the Information Technology and Communications Engineering degree at the Tecnológico de México Campus Salvatierra can develop. The proposed work can be applied to any higher education educational institution. To determine the skills students can develop, a review of the different programs and calls for students to participate was carried out. The purpose of the proposed monitoring system is to record skills that students have throughout their academic life. Among which are academic competitions, research projects, training, certifications, communication, languages, work experience, class projects, class grades and hobbies.
OS CUIDADOS ÀS PESSOAS COM DIABETES MELLITUS NA ATENÇÃO PRIMÁRIA À SAÚDE
Authors: do Nascimento Andrade Feitosa Ankilma , da Silva Alexandre Bruno , Amanda Mota Seabra Cícera , Cabral Falcão Dassaev
Published: December 2024

INTRODUÇÃO: O diabetes mellitus é uma condição crônica caracterizada por hiperglicemia persistente, resultante de defeitos na secreção ou ação da insulina, ou ambos. Na atenção primária, seu manejo é fundamental, pois permite diagnóstico precoce, controle eficaz e prevenção de complicações. OBJETIVOS: Avaliar a atenção à saúde desenvolvida pelos integrantes da Atenção Primária à Saúde às pessoas com diabetes mellitus. MÉTODO: Trata- se de um estudo com abordagem qualitativa, com a utilização do método de revisão da literatura, realizada durante o período de setembro a novembro de 2024, a partir das bases de dados Scientific Electronic Library Online (SciELO) e Biblioteca Nacional em Saúde (BVS). Como critérios de inclusão foram utilizados artigos nacionais e internacionais que estivessem disponíveis nas bases de dados citadas, com resumo disponíveis e artigo de disponibilização gratuita publicados entre o ano de 2019 e 2024. RESULTADOS: Tendo em vista as evidências discutidas, ressalta-se que a equipe multiprofissional, no planejamento e na realização das intervenções voltadas às pessoas com diabetes, deve considerar os aspectos individuais, sociais, culturais e coletivos para adotar estratégias que promovam melhorias na qualidade de vida. Além disso, a literatura evidencia que os pacientes que recebem visita domiciliar dos profissionais de saúde da atenção primária estão associados à melhor qualidade de vida. CONSIDERAÇÕES FINAIS: O fortalecimento do vínculo entre equipe de saúde e paciente contribui para melhores desfechos, destacando a atenção primária como pilar fundamental no enfrentamento do diabetes mellitus e na promoção da qualidade de vida dos indivíduos acometidos.

Palavras-chave: Diabetes Mellitus; Atenção Primária à Saúde; Promoção à Saúde.
O USO DOS ANÁLOGOS DO GLP-1 NO TRATAMENTO DA OBESIDADE E SEUS RISCOS
Authors: Abrantes Fernandes Caroline , Guilherme Ferreira Marques Galvão José , Costa e Sá Lima Íris , Emília Formiga Marques Ana
Published: December 2024

A obesidade é uma doença crônica com consequências sistêmicas e o uso de análogos de GLP-1 é considerado um coadjuvante terapêutico no seu tratamento. Assim, o presente artigo tem como objetivo realizar uma revisão de literatura sobre o uso dos análogos de GLP-1 no tratamento da obesidade. Os objetivos específicos incluem: caracterizar os análogos de GLP-1 no tratamento da obesidade; apresentar os riscos à saúde provenientes do uso indevido desses análogos; e discutir o uso indiscriminado dos análogos de GLP-1 nesse contexto. A metodologia de pesquisa adotada foi uma revisão de literatura, com análise descritiva e método dedutivo. Os dados foram catalogados com base em artigos de revisão e artigos originais, disponíveis nas bases Pubmed Unique Identifier e SCIELO (Scientific Electronic Library Online), com critérios de inclusão para artigos publicados entre 2019 e outubro de 2023, nos idiomas português e inglês, e disponíveis na íntegra. Os critérios de exclusão englobaram revisões de literatura, monografias, dissertações e teses, além de artigos em plataformas pagas. Dos resultados, observou-se que os análogos de GLP-1, particularmente a Liraglutida, podem estimular as células beta pancreáticas, retardar o esvaziamento gástrico e, quando combinados com mudanças no estilo de vida, contribuir para a redução do peso corporal e dos níveis glicêmicos, sendo aplicáveis no tratamento da obesidade. Portanto, empreende-se que a eficiência desses análogos é superior aos efeitos colaterais observados e que os análogos de GLP-1 são utilizados como coadjuvantes no tratamento da obesidade, com informações convergentes sobre sua eficácia.

Palavras-chave: Tratamento; Obesidade; Análogos do GLP-1; Riscos.
Performance, buen gusto y sus saberes en la formación del doctorado: Un análisis del relato confesional en San Luis Potosí, México
Authors: Culebro-Tello Rafael
Published: December 2024

El estudio de las condiciones y complejidades de los programas de posgrado es una estrategia que aporta al entendimiento, desarrollo y continuidad de la oferta formativa en las instituciones de educación superior. El posgrado desde el relato es una construcción simbólica que se capitaliza desde los saberes y lo político. Este performance es la urdimbre que tejen la trama del buen gusto académico como rasgo distintivo que legítima a sus egresados. Esta investigación es un estudio de caso de corte cualitativo-inductivo, emplea las categorías performance, habitus y vivencia para delimitar, desde el relato de los egresados de un programa regional de Doctorado en Desarrollo Educativo, el espacio simbólico en la formación para conocer su aporte. Emplea como técnica el relato confesional para obtener porciones discursivas, procesadas en una matriz y analizadas en la aplicación QDA Miner 1.4. Los resultados obtenidos permiten construir el argumento sobre el doctorado como una etapa que padecieron sus egresados entre el cumplimiento de las expectativas académicas y la formación. Una parte de la vida académica del doctorante se dedica a asimilar el buen gusto académico, dispositivo que permite la reproducción del capital cultural de este espacio. En ese sentido, el doctorado es crítico en sus estrategias didácticas y en el manejo de los contenidos en sus seminarios, pero los estudiantes no son formados para cuestionar el conjunto de habituaciones que heredan del programa hasta que experimentan una mirada desde afuera, el doctorado forma y después de padecerlo es posible transformar a sus herederos.
Organization of Palliative Care for the Population of the Republic of Crimea
Authors: Tretiakova Olga S.
Published: December 2024

Introduction: Increased life expectancy and related population ageing, growing rates of cancer and chronic diseases have led to a greater demand for palliative care and its adequate organization.
Objective: To analyze organization of palliative care for the population of the Republic of Crimea.
Materials and methods: The materials of the study included laws and regulations of the Russian Federation and the Republic of Crimea, analytical reports of the Chief Specialist of the Ministry of Health of the Republic of Crimea, and statistics collected by the Federal State and Crimean Statistics Services (Rosstat and Сrymstat) for 2020–2022. The data were analyzed using standard methods of variation statistics in Statistica 10 for Windows. Dynamic indicators, including absolute growth, growth and increment rates, were calculated and evaluated.
Results: A palliative care service has been established and is functioning in the Republic of Crimea; its activities are regulated by regional legal and regulatory acts. The work of relevant offices and six visiting nursing teams has been launched at 11 health facilities of the Crimea. Disease-specific inpatient palliative care is provided by 17 facilities. The staffing of regional outpatient and inpatient palliative care facilities is 80 % and 78.8 %, respectively.
Conclusions: The regulatory framework has been established in the Republic of Crimea and harmonized with the federal one. The regional model for palliative care organization has been created, is functioning and constantly improved. To increase its availability, regional palliative care facilities should overcome the staffing shortage in the first place.
Comparative Analysis of Self-Assessed Health of Medical University Students
Authors: Ivanov Dmitry O. , Lisovskii Oleg V. , Moiseeva Karina E. , Lisitsa Ivan A. , Gritsinskaya Vera L.
Published: December 2024

Introduction: Studying in higher school is associated with increased intensity of impact of various adverse factors, the combination of which can cause depletion of physiological reserves of the body. Monitoring the health status of students allows timely detection and correction of emerging deviations.
Objective: To establish the health status of medical university students in the process of learning.
Materials and methods: In 2022–2023, we conducted a questionnaire-based survey of 1,587 students aged 17 to 25 years to analyze their physical development indicators, incidence and prevalence rates. A 36-item short form survey instrument (SF-36) was used to determine their self-rated health.
Results: Most students had deviations in physical development largely related to underweight in the girls (21.0 %) and overweight in the boys (18.8 %). Obesity was detected in 4.8 % of the male respondents. 3.9 % of the girls and 1.8 % of the boys reported having acute respiratory infections five or more times a year while 24.2 % of the boys and 11.4 % of the girls had chronic diseases. 55.9 % of the boys and 40.5 % of the girls rated their health as excellent and very good.
Conclusions: Health deterioration and deviations in physical development observed in the students by the time of graduation necessitate additional studies of factors that can have a negative impact on their health.
Immune Disorders in Children Exposed to Airborne Benzene and Phenol
Authors: Zaitseva Nina V. , Dolgikh Oleg V. , Nurislamova Tatyana V. , Maltseva Olga A. , Popova Nina A. , Chinko Tatyana V. , Alikina Inga N. , Motskus Anna V.
Published: December 2024

Introduction: Motor transport exhausts contain more than 250 chemicals, including benzene and phenol. Inhalation exposure to the latter can induce immune disorders in children.
Objective: To analyze immune disorders in children exposed to airborne benzene and phenol in the area with heavy traffic.
Materials and methods: The objects of the study included ambient air of the observation and reference areas and two respective groups of 286 and 97 preschoolers. Blood levels of benzene and phenol were assayed by gas chromatography and high-performance liquid chromatography, respectively. The established differences between the groups were tested for statistical significance using Student’s t-test and Z-test. The Pearson’s goodness-of-fit test (χ2) was used to determine normality of the quantitative data.
Results: In 2019–2022, average annual concentrations of benzene and phenol (n = 368) in the high traffic area demonstrated up to a 3.5- and 3.26-fold excess of the maximum allowable concentration (MAC), while in the reference area, they were 0.91 and 0.58 of the annual MAC (n = 268), respectively. Due to long-term inhalation exposure to benzene and phenol, blood levels of the latter in the observation group were 2.3 and 2 times higher than in the controls, respectively. The findings were verified by statistical cause-and-effect relationships between ambient concentrations of benzene and phenol and their blood levels in children.
Conclusion: We established an imbalance of cell differentiation phenotypes, elevated production of immunoglobulins G specific to benzene and phenol, and stress of the key adaptation compartments.
Awareness of Women with Different HIV Status about Papillomavirus Infection
in Some Countries of Eastern Europe and Central Asia
Authors: Prilepskaya Diana R. , Domonova Elvira A. , Popova Anna A. , Samarina Anna V. , Mayer Yuliya I. , Yoqubov Izzatullo R. , Gasich Elena L. , Rzayeva Adela M. , Toitukova Molmol M. , Suvorova Zoya K. , Pokrovsky Vadim V.
Published: December 2024

Introduction: Cervical cancer ranks fourth among the most common cancers in women worldwide. HIV-infected women account for 5 % of all cases of cervical cancer. Poor awareness of the role of human papillomavirus in the development of malignant neoplasms has a negative impact on the effectiveness of preventive measures.
Objective: To compare the level of awareness of papillomavirus infection in women stratified by HIV status in some countries of Eastern Europe and Central Asia.
Materials and methods: The survey using the control question technique was conducted in 2022–2024 among 600 HIV-positive and 600 HIV-negative women aged 39.6 ± 12.3 years living in the Russian Federation, the Republic of Azerbaijan, the Republic of Belarus, the Kyrgyz Republic, and the Republic of Tajikistan. The systematized data was processed automatically using an online platform. A comparative analysis of the data obtained with results of the previous study (2016–2018) was carried out. Statistical data processing was carried out using the STATTECH online service.
Results: 49.8 % (95 % CI: 45.9–53.8) of HIV-positive and 33.5 % of HIV-negative (95 % CI: 29.8–37.4) women were unaware of papillomavirus infection and its effects. The statistical significance of the results was confirmed using a control question (p < 0.001). The main sources of information reported were healthcare professionals (44.5 % to 83.5 %), Internet, acquaintances (12 % to 45.5 %), and mass media (0 % to 6 %). The percentage of HIV-positive women unaware of HPV showed a 3.3-fold decrease (from 11.6 % to 3.5 %) compared to the years 2016–2018.
Conclusions: Our findings indicate a lower awareness of papillomavirus infection among HIV-positive than among HIV-negative women, regardless of the region of residence. We noted a positive trend towards greater trust in medical personnel and increased awareness through obtaining information on the Internet. The need to strengthen awareness raising and education using all available resources among the population was confirmed.
Influenza Viruses Detected in Lethal Cases in the Russian Federation
in the 2023–2024 Respiratory Virus Season
Authors: Boldyrev Nikita D. , Panova Anastasia S. , Kolosova Natalia P. , Danilenko Alexey V. , Shadrinova Kiunnei N. , Svyatchenko Svetlana V. , Onkhonova Galina S. , Muratova Alina R. , Goncharova Natalia N. , Gudymo Andrei S. , Marchenko Vasiliy Y. , Ryzhikov Alexander B.
Published: December 2024

Introduction: Influenza is a highly contagious disease which can cause severe complications and even death, particularly in high-risk populations. Continuous monitoring and careful testing of seasonal influenza viruses, especially for severe cases, is necessary to develop and optimize prevention and treatment.
Objective: To establish genetic and antigenic characteristics of influenza viruses detected in lethal cases in the Russian Federation in the 2023–2024 respiratory virus season.
Materials and methods: From September 29, 2023 to June 1, 2024, 859 specimens from influenza cases (nasopharyngeal swabs) and 101 autopsy specimens of trachea, bronchi, and lungs from lethal cases of the disease from 57 regions of the Russian Federation were analyzed by PCR. For those with a sufficient amount of genetic material, whole-genome sequencing was performed using the Illumina MiSeq platform.
Results: The 2023–2024 influenza season in the Russian Federation was characterized by the dominance of A/H3N2 viruses of subclade 2a.3a.1. Influenza A/H1N1pdm09 and influenza type B viruses were detected to a lesser extent in that period. Additional diversification of A/H3N2 viruses was observed during the season with accumulation of amino acid substitutions in the hemagglutinin antigenic sites. Most lethal cases were among those at high risk and unvaccinated. No mutations associated with increased pathogenicity and virulence were identified in A/H3N2 viruses from lethal cases. No molecular markers of drug resistance to neuraminidase inhibitors and baloxavir marboxil were identified in all viruses tested in the 2023–2024 season.
Conclusion: Influenza A/H3N2 viruses from the lethal cases of the diseases tested at the State Research Center for Virology and Biotechnology “Vector” in the 2023–2024 respiratory virus season were similar to those detected in recovered patients. The isolated viruses were genetically and antigenically similar to the vaccine strain and had no markers of increased pathogenicity or drug resistance.
Climate Change and Its Impact on Female Reproductive Health
Authors: Vadiraj Kalya T. , Rajashekara Nitin Kalsi , Jayashankaraswamy Bindu , Mathad Rajesh V. , Nataraj Raghu
Published: December 2024

A worldwide occurrence, climate change has profound effects on many facets of human existence, including health. The frequently disregarded relationship between climate change and female reproductive health is the major topic of this review. The reproductive health of women has particular challenges due to climate change, which is also linked to extreme weather events and environmental degradation. Maternal and child health outcomes are jeopardized, access to reproductive healthcare services is restricted, and healthcare infrastructure is disrupted as a result of rising temperatures, changing precipitation patterns, and an increase in the frequency of natural disasters. Furthermore, alterations in environmental factors have the potential to worsen the existing disparities in reproductive health, with a disproportionate impact on marginalized communities. A comprehensive strategy that incorporates gender-sensitive legislation, community resilience-building, and climate change mitigation techniques is needed to address the psychosocial effects of climate change on women. Understanding the intersectionality of vulnerabilities and addressing the particular difficulties experienced by women in various situations are crucial. A comprehensive strategy that takes into account sustainable farming methods, healthcare access, economic empowerment, and nutritional education is needed to address the complex interactions between food security and female fertility behavior. Communities' general growth and well-being can benefit from policies and initiatives that work to enhance both food security and reproductive health. One should keep in mind that this field is complex and constantly changing, and our understanding of these relationships is always expanding. The current review delves into the various ways that climate change affects the health of women through direct and indirect pathways. These include changes in fertility rates, elevated risks of unfavourable pregnancy outcomes, and increased rates of maternal illness and mortality.
Prevalence of Some Bacterial and Viral Pathogens in Ixodid Ticks Collected
in Northwest Russia
Authors: Karmokov Islam A. , Riabiko Ekaterina G. , Baimova Regina R. , Khalilov Erik S. , Grechishkina Daria I. , Lyzenko Ivan S. , Sharova Alena A. , Lunina Gelena A. , Freylikhman Olga A. , Sokolova Olga V. , Bubnova Lilia A. , Safonova Olga S. , Bespyatova Lyubov A. , Kalinina Elena L. , Tokarevich Nikolay K.
Published: December 2024

Introduction: Ticks are among the most common vectors of pathogens that cause infectious diseases in humans. According to official government statistics, tick-borne infections are the most common zoonotic diseases in Russia, particularly in the Northwestern Federal District.
Objective: To detect the prevalence of Borrelia burgdorferi sensu lato, Rickettsia spp. SFG, Ehrlichia chaffensis/ E. muris, Coxiella burnetii, tick-borne encephalitis virus, and Anaplasma phagocytophilum in ixodid ticks collected in the Arkhangelsk, Leningrad, and Pskov regions, the Republic of Karelia, and the city of St. Petersburg.
Materials and methods: We tested 3,585 adult ixodid ticks of two species: Ixodes ricinus (48 %) and Ixodes persulcatus (52 %). Questing ticks were collected from vegetation by flagging and then tested individually by real-time PCR for genetic markers of tick-borne pathogens using commercial test systems and following the manufacturer’s instructions.
Results: 35.8 % of the collected ticks contained the genetic material of at least one pathogen. The prevalence of B. burgdorferi s.l. was 24.7 %; Rickettsia spp. SFG – 10.1 %; E. chaffensis/ E. muris – 6.9 %; C. burnetii – 5.1 %; tick-borne encephalitis virus – 2.1 %, and A. phagocytophilum – 1.1 %. Multiple pathogens were detected in 8.4 % of the ticks in 15 different combinations, the most common being B. burgdorferi s.l. + E. chaffensis/E. muris (3.5 %) and B. burgdorferi s.l. + Rickettsia spp. SFG (2.7 %).
Conclusions: Our findings show the existence of active natural foci of tick-borne infections in the Northwestern Federal District and justify the expediency of continuous monitoring of the prevalence of tick-borne pathogens in ixodid ticks.
Anti-Inflammatory and Antioxidant Potential of Corn Silk Extract in Carrageen an-Induced Inflammation in Albino Rats
Authors: Ali Meraj , Tyagi Dr C k
Published: December 2024

This study investigates the anti-inflammatory and
antioxidant potential of corn silk (Stigma maydis)
extract in the context of carrageenan-induced
inflammation in albino rats. Renowned for its rich
array of bioactive phytochemicals, including
polyphenols, flavonoids, and carotenoids, corn silk
has demonstrated significant therapeutic properties
in traditional medicine. The extract's active
components, such as tannins and phenols,
contribute to its diverse pharmacological activities,
including antioxidant, anti-inflammatory, and
antidiabetic effects. Notably, corn silk can activate
peroxisome proliferator-activated receptors,
suggesting its role in diabetes management. With
its high antioxidant capacity, corn silk extract may
mitigate oxidative stress and offer therapeutic
options for various diseases. Overall, the findings
underscore the potential of corn silk extract as a
valuable resource for anti-inflammatory and
antioxidant applications in healthcare