bluuebunny/crossref_metadata_2025 huggingface dataset:
Mini-Open Rotator Cuff Tear Repair: An Institutional Experience with a Midterm Follow-up
Authors: Bashir Adil , Seth Suleiman , Wani Iftikhar H. , Farooq Munir , ul Gani Naseem , Naqshi Berjina Farooq
Published: January 2019

Background. Rotator cuff tears have long been recognised as a cause of pain and disability. Over the past decades the treatment of rotator cuff tears has evolved from an open procedure to a mini-open procedure to an all-arthroscopic one. The indications and benefits of each of the procedures are still debated. The purpose of this study was to observe the results of “Mini-open repair rotator cuff tear”.
Material and methods. This was a prospective study conducted in the postgraduate department of Ortho­paedics Government Medical College, Srinagar, from March 2013 to January 2018 with cases followed up for a minimum of 3 years. This study included 50 patients of either sex with non-massive full thickness tears of rotator cuff.
Results. The mean UCLA score improved from 10.96 preoperatively to 30.68 at final follow-up. Overall, 88% of the patients achieved excellent or good results and 92% were satisfied. No significant difference was noted in functional outcomes between traumatic and degenerative tears. Size of tear seems to be a determining factor in the functional outcome. Stiffness as a complication occurred in two patients.
Conclusion. 1. Mini-open rotator cuff tear repair eliminated sym­pto­matic full thickness rotator cuff tears with significant improvement in functional scores. 2. There were no major complications of the surgical procedure adop­ted or the fixation method used. 3. Mini-open rotator cuff repair remains a useful technique despite advan­ces in arthroscopy.
Treatment of Primary Hip Arthroplasty Complications. Case Study
Authors: Kamiński Paweł , Zawojski Adam , Jaworski Jerzy Mirosław , Wilk-Frańczuk Magdalena
Published: January 2019

Intraoperative periprosthetic femoral fracture during hip arthroplasty is one of the most serious surgical com­plications. Its consequences can be minimized with correct diagnosis and early institution of appropriate treatment.
This paper presents the management of a periprosthetic femoral fracture complicated by infection in a 53-year-old female patient.
The patient underwent three revision surgeries. The first one consisted in treating the fracture and was complicated by another fracture and infection. This was followed by a two-stage treatment of the infection with a cementless revision stem arthroplasty.
Arthroplasty procedures should be preceded by appropriate preoperative planning. In the treatment of peri­pro­sthetic fractures, it is essential to use appropriate implants and adhere to the AO principles of fracture ma­nagement.
THERMO-MECHANICAL ANALYSIS OF HETEROGENEOUS SOLID ROCKET PROPELLANT
Authors: Cegla Marcin , Zmywaczyk Janusz , Koniorczyk Piotr
Published: January 2019

The article presents results of thermo-mechanical analysis of heterogeneous solid rocket propellant H2, with special attention devoted to determining the glass transition temperature and softening temperature. Mechanical properties such as storage modulus (E’), loss modulus (E’’) and tan(δ) were measured using NETZSCH DMA 242C analyzer within temperature range from -120oC to +80oC at 2 K/min of heating rate and frequency of applied force
f = 1 Hz. Relative thermal expansion as well as the Coefficient of Linear Thermal Expansion (CLTE) of H2 sample were determined using NETZSCH DIL 402C dilatometer within temperature range from 30oC to 80oC at 1 K/min of heating/cooling rate. The thermophysical properties including thermal conductivity, thermal diffusivity, and specific heat were determined within temperature range from -20oC to +80oC using KD2 Pro apparatus.
African Americans in the Civil War Years
Authors: Escott Paul D.
Published: January 2019

The nation’s African Americans, living in both the North and the South and in freedom and in slavery, formed a diverse population. This chapter focuses first on the South’s slaves, whose initiatives for freedom—by running to Union lines—changed the nature of the war. It also examines the determined political activism of black people in the North and the pressures they exerted on the government in order to win not just freedom for the race but equal rights as well. Questions about the organization and resources of Northern blacks as well as the connections between the Northern and Southern black populations deserve attention, and the chapter offers many suggestions or questions.
Military History
Authors: Escott Paul D.
Published: January 2019

This chapter focuses on the major strategic issues relating to the war and the way those issues were debated in both the North and the South. Questions of strategy, operations, generalship, relations between civilian and military leaders, and internal political or societal constraints on military action are issues deserving greater exploration. There are important controversies relating to theaters, departmental commands, and irregular warfare. An important challenge is to find ways to integrate battlefield events and home-front issues. The chapter suggests approaches to questions of civilian control, the status of soldiers and military heroes, and the experience of soldiers during and after the conflict.
Environmental Approaches to the Civil War
Authors: Escott Paul D.
Published: January 2019

This chapter deals with environmental approaches to studying the Civil War era. It discusses how the environment affected the war and how human beings and their warfare changed the land. Considering the environment as a set of relationships between the physical world and many types of human activity broadens the focus to include economic, psychological, and gender-related results and interactions with the environment.
Representation of physical activity domains and sedentary behaviors across categories of gender and disability in children’s TV cartoons
Authors: Gans-Segrera Sandra , Molina-García Javier , Martínez-Bello Vladimir
Published: January 2019

Television (TV) cartoons could reflect and shape social values about children’s health-related behaviors. The main aim of this study is to analyze the portrayal of physical activity (PA) domains in the most popular Spanish children’s television (TV) cartoons. It is performed a content analysis of each scene following a coding scheme. The sample selected included the five most popular children’s TV cartoons for the 2013-2014 period in Spain. Our results show a large gap between the modest representation of different PA domains compared to the overwhelming depiction of sedentary behaviors. We do not find evidence of males and females participating equally in a variety of PA domains, and we fail to identify any characters with disabilities, reinforcing evidence on their invisibility in different media. Current children’s cartoons in Spain are not adequate regarding promoting healthy behaviors related to PA. While policy makers need to work on limiting sedentary time in pre-schoolers, children, teachers, and parents should be encouraged to develop their critical thinking about the under-representation of health-related behaviors—including PA—on children’s TV cartoons. The study further contributes to the scientific literature by shedding light on the typical health-related behaviors coded in analyses of children’s cartoons.
Body-image and -size perception after a single session of HIIT body work in healthy adult men
Authors: Rica Roberta L , Miranda João M , Machado Alexandre F , Evangelista Alexandre L , Teixeira Cauê La Scala , Gama Eliane F , Pinto Graça , Reis Victor Machado , Bocalini Danilo S
Published: January 2019

It was our objective to analyze the effects of a single session of whole body HIIT on body-image and -scheme parameters of healthy adult men. Twenty-one active, healthy adults performed high-intensity intermittent training based on full body exercise. The training session involved 20 sets of 30 second all-out exercise and 30 seconds of passive recovery between sets. All subjects underwent blood lactate measurement, rate of perceived exertion, feeling scale and body image assessment and perception of body size measurements. Significant differences (p<0.001) were found on blood lactate but not in feeling scale. The values of current and adequate silhouette did not differ between each other and the real silhouette. Significant differences were found on Image Marking Procedure (IMP) (p< 0.003). Additionally, significant differences (p= 0.009) were found on prevalence of adequate, hypoeschematic and hypeschematic. Although alteration was not found on self-perception of body image, a single session of HIIT body work promoted alteration on body size perception in healthy adult men.
A retrospective analysis of retirement of football players in Portugal
Authors: Carapinheira António , Torregrossa Miquel , Mendes Pedro , Guedes carvalho Pedro , Travassos Bruno Filipe Rama
Published: January 2019

The purpose of this study was to analyse the retirement of elite football players in Portugal. Specifically, the quality of retirement and the resources available were evaluated. To develop an understanding of the process of the sporting retirement of elite football players we used data from in-depth, semi-structured interviews with ninety professional players from the portuguese football national team.  Most of the elite Portuguese footballers we investigated retired from sport between 36 and 40 years of age, their retirement had been involuntary and it had taken them less than a year to accept retirement. Most had only been educated to secondary level and had a strong athletic identity, no plans for their post-football career exist and relied on family as their main psychological support. None of the players had received support from a formal programme. Despite of the findings being consistent with previous research from other Southern European cultures, it seems that the athletic retirement of portuguese footballers has some particularities. Most portuguese footballers retired later and had longer playing careers than athletes in other countries. In addition, retirement was involuntary in most of cases, yet players reported that it took them a relatively short time to accept retirement.
Tarihi Yapıların Yeniden Kullanılmasında Yapı-İşlev Uyumu: Rize Müzesi Örneği / The Structure-Function Coherence in the Reuse of Historical Buildings: Rize Museum Sample
Authors: İslamoğlu Özge
Published: January 2019

Abstract

The reuse of historic buildings for the purpose of protection is an important tool in the preservation of the historic buildings. With this understanding of protection, the building continues its life and, at the same time, economic and cultural continuity is ensured. In this study, Sarı Ev which have been refunctioned today and known as Rize Museum, reflecting architectural texture of Eastern Black Sea and representing the architectural heritage of the city, has been evaluated in the context of reutilization. The aim of the study is to draw attention to the importance of function selection in reuse by showing this structure, which originally used to function as a house, that can be compatible with the new function. The aim of the study is to draw attention to the importance of function selection in reuse by showing this structure, which originally used to function as a house, that can be compatible with the new function. The suitability of the structure considering its spatial and functional requirements for reuse has been assessed. The adaptation of the building to its new function was examined by the observation and spatial analysis method and evaluated qualitatively. The result of the evaluation showed that the original spatial installations of the construction were adaptable to the new function with very little intervention. In this study, a positive example of the proper function selection for the reuse of construction has been presented and emphasized as an important way for preservation in the face of rapidly changing circumstances of present conditions.

Öz

Tarihi yapıların koruma amaçlı olarak yeniden kullanımı, yapıların sahip olduğu değerlerin korunmasında önemli bir araçtır. Değerlerin yaşatıldığı bu koruma anlayışı ile yapı yaşamına devam etmekte, aynı zamanda ekonomik ve kültürel açıdan süreklilik sağlanmaktadır. Bu çalışmada, Doğu Karadeniz’in mimari dokusunu yansıtan ve kentin mimari mirasları arasında yer alan Sarı Ev incelenmiş ve Rize müzesi olarak yeniden kullanıma açılması ile ilgili değerlendirmeler yapılmıştır. Çalışmanın amacı özgün işlevi konut olan bu yapının yeni işlev ile uyumunun ortaya koymak ve yeniden kullanımda işlev seçiminin önemine dikkat çekmektir. Bunun için yapının yeniden kullanımındaki mekânsal ve işlevsel gereksinimlerine uygunluğu değerlendirilmiştir. Yapının yeni işleve olan uyumu, yapılan gözlem ve mekânsal analiz yöntemiyle sorgulanmış, niteliksel açıdan bir değerlendirme yapılmıştır. Yapılan değerlendirme sonucu, yapının özgün mekânsal kurgularının değişime uğramadan, çok az müdahale ile yeni işleve uyum sağladığını göstermiştir. Yeniden kullanımda yapıya uygun işlev seçiminin olumlu bir örneğinin ortaya konulduğu çalışmada, bu yöntemin günümüz koşullarında hızla değişen koşullar karşısında korumada izlenebilecek önemli bir yol olduğu vurgulanmaktadır.
Türk Halk Kültüründe El Sanatlarının Önemi: Kıbrıs Örneği / The Importance of Handicrafts in Turkish Folk Culture: The Case of Cyprus
Authors: Miralay Fatma
Published: January 2019

Abstract

Handicrafts are one of the essential elements of Cypriot Turkish folk culture. The cultural diversity of Cyprus Island due to the fact that it was home to various cultures in different times reflected to the handicrafts as well. Handicrafts in Cyprus have mostly taken place for usage and commercial purposes in historical process; however, in modern times they are used as decorative objects. Handicrafts carry local features in the maintaining of traditions of Cypriot Turkish people and the sustainability of the values of Turkish culture. Rich in usage, make and material, Cypriot Turkish handicrafts can be generally examined under the titles of embroidery and wood engraving. Examples of embroidery or cotton weaving include Lefkara work, Lapta work, Koza work and needle lace. Dowry chest and geotextile are the most well-known examples of Cypriot Turkish wood engraving. All of the foregoing are important cultural elements of Cypriot Turkish identity. This paper examines the characteristic features of handicrafts belonging to Cypriot Turkish folk culture in technical and material terms; it also aims at revealing its place and importance in Cypriot Turkish social and cultural life.

Öz

El sanatları Kıbrıs Türk halk kültürünün önemli unsurların bir tanesidir. Kıbrıs Adasının farklı dönemlerde çeşitli kültürlere ev sahipliği yapmış olmasından kaynaklanan kültür çeşitliliği el sanatlarına da yansımıştır. Kıbrıs’ta el sanatları, tarihsel süreçte büyük ölçüde kullanım ve ticari amaçlı yer alırken, modern zamanlarda dekoratif obje olarak kullanılmıştır. Kıbrıs Türk halkının geleneklerinin sürdürülmesi ve Türk kültürü değerlerinin yaşatılmasında, el sanatları yöresel özellikler taşımaktadır. Kullanım, yapım ve malzeme açısından zengin olan Kıbrıs Türk el sanatları, genel olarak Nakış ve Ahşap Oymacılık başlıkları altında incelenebilir. Lefkara İşi, Lapta işi, Koza işi ve İğne Danteli nakış veya pamuklu dokuma türlerine örnek gösterilebilir. Çeyiz sandığı ve sesta işçilikleri (bitkisel örücülük) Kıbrıs Türk ahşap oymacılığının en iyi bilinen örnekleridirler. Tüm bunlar Kıbrıs Türk kimliğinin önemli kültürel unsurlarıdırlar. Bu araştırma, Kıbrıs Türk halk kültürüne ait el sanatlarının teknik ve malzeme açısından karateristik özelliklerinin incelenmesini ayrıca, Kıbrıs Türk sosyal ve kültürel yaşamındaki yeri ve önemini ortaya çıkarmayı hedeflemektedir.
Psikiyatrik Vakalardan Esinlenen Edebi Eserlerde Kadın Karakterler Üzerine Bir İnceleme / An Investigation on Female Characters in Literary Works Inspired by Psychiatric Cases
Authors: Üçler Fatma
Published: January 2019

Abstract

The aim of this study is to evaluate the text of psychiatric cases from a literary perspective. Based on the stories and therapies of her patients, Gülseren Budayıcıoğlu who is a psychiatrist presents them to the reader in her short stories and novel fictions. We will subject the works based on female characters to literary analysis. The author's first work, Madalyonun İçi, consists of short stories. The second work, Günahın Üç Rengi, basically contains three main stories. His third work, Hayata Dön, despite being a novel, displays cases of patients. In these works, the author reveals his identity as a doctor and the perception of reality is always open. The fourth work, Kral Kaybederse, is a technical novel fiction. In every work, woman is in the foreground. In her works, the effects of the damage on the psychology of the women and, as a psychiatrist, the authors’ approach to the problems and his guidance to the women on how to deal with these problems are included.

Öz

Bu çalışma, edebiyatı psikanalitik açıdan değerlendirmek yerine; psikiyatrik vakalardan oluşan metni, edebî açıdan değerlendirmek amacındadır. Psikiyatrist Dr. Gülseren Budayıcıoğlu, hastalarının hikâyelerinden ve terapilerinden yola çıkarak öykü ve roman kurmacası içinde bunları okuyucuya sunmaktadır. Eserleri, kadın karakterlerini esas alarak edebî çözümlemeye tabi tutacağız. Yazarın ilk eseri Madalyonun İçi, kısa kısa öykülerden oluşur. İkinci eser Günahın Üç Rengi, temelde üç esas öykü barındırır. Üçüncü eseri Hayata Dön, romandır yine de içinde, kısa hasta vakaları yer alır. Bu eserlerde yazar, Doktor kimliğini açık eder, gerçeklik algısı daima açıktır. Dördüncü eser Kral Kaybederse’de teknik roman kurgusu oluşmuştur. Her eserde ön planda olan kadındır. Eserlerdeki kadınların aldığı hasarların psikolojilerine nasıl etki ettiği, yazarın psikiyatr olarak sorunlara yaklaşımı ve kadınlara, bu sorunlarla nasıl baş edebilecekleri konusunda yol göstericiliğini içerir.
Changes in interleukin-27 levels in patients with acute coronary syndrome and their clinical significance
Authors: Zhang Lin , Zhang Junfeng , Su Shaohong , Luo Suyan
Published: January 2019

Background

This study evaluated changes in interleukin (IL)-27 levels in patients with acute coronary syndrome (ACS) and their influence on Th1, Th2, and Th17 cells.

Methods

Serum levels of IL-27, IL-4, IL-17, and interferon (IFN)-γ in healthy subjects as well as patients with ACS, including stable angina pectoris (SA), unstable angina pectoris (UA), and acute myocardial infarction (AMI), were determined using an enzyme-linked immunosorbent assay. The proportions of Th1, Th2, and Th17 cells among peripheral blood mononuclear cells (PBMCs), were measured using flow cytometry, after incubation with phorbol myristate acetate (PMA) for 4 h. The proportions of Th1 and Th17 cells among PBMCs in AMI and UA were detected after stimulation with IL-27 or PMA + IL-27 for 4, 8, and 12 h.

Results

Serum levels of IL-27 in patients with AMI and UA were significantly lower than those in SA and control groups, while serum levels of IL-17 and IFN-γ in AMI and UA groups were dramatically increased compared to those in SA and healthy control groups. However, there were no statistically significant differences in serum IL-4. The proportions of Th1 and Th17 cells among PBMCs were statistically significantly higher in the AMI and UA groups than those in the SA and control groups, while there was no statistically significant difference in the proportion of Th2 cells among different groups. For patients with AMI and UA, the effect of co-stimulation of PBMCs with PMA and IL-27 was not significantly different from that of PMA single stimulation, while PMA + IL-27 co-stimulation lowered the Th17 cell proportion significantly compared to PMA single stimulation.

Discussion

Compared to SA patients and healthy controls, patients with ACS (AMI + UA) had lower serum levels of IL-27 and higher proportions of PBMC Th1 and Th17 cells, which could be attributed to the inhibitory effects of IL-27 on the proliferation of Th17 cells. These results indicated that IL-27 could be a novel therapeutic target in ACS patients.
Temperature-mediated feeding between spring-associated and riverine-associated congeners, with implications for community segregation
Authors: Craig Cody A. , Maikoetter Jeremy D. , Bonner Timothy H.
Published: January 2019

Freshwater fish communities segregate along water temperature gradients attributed in part to temperature-mediated physiological processes that affect species fitness. In spring complexes of southwest USA, spring complexes with narrow range of water temperatures are dominated by a community of fishes (i.e., spring-associated fishes), whereas riverine habitats with wide-range of water temperatures are dominated by a different community of fishes (i.e., riverine-associated fishes). The purpose of this study was to test a prediction of the concept that temperature-mediated species performance is a mechanism in maintaining community segregation. We predicted that a spring-associated fish (Largespring Gambusia Gambusia geiseri) would feed first and more often in a pairing with a riverine-associated fish (Western Mosquitofish G. affinis) at an average spring temperature (23 °C) and that the riverine-associated fish would feed first and more often in a pairing with the spring-associated fish at a warm riverine temperature (30 °C). Among four trails consisting of 30 pairings, at the spring complex temperature (23 °C), Largespring Gambusia had a greater number of first feeds (mean ± 1 SD, 5.0 ± 0.82) than Western Mosquitofish (2.5 ± 1.73) and had greater mean number of total feeds (1.9 ± 0.31) than Western Mosquitofish (0.81 ± 0.70). At the riverine environment temperature (30 °C), Western Mosquitofish had a greater number of first feeds (5.25 ± 1.71) than Largespring Gambusia (2.5 ± 1.73) and had greater mean number of total feeds (2.78 ± 1.05) than Largespring Gambusia (0.94 ± 0.68). Our findings suggest that temperature-mediated species performance could be maintaining segregation between the two fish communities. This study benefits our understanding of distributional patterns and improves threat assessments of stenothermal aquatic organisms.
Role of the larval feeding morphology and digestive enzyme activity in the early development of the polychaete Boccardia wellingtonensis
Authors: Doherty-Weason Daniel , Oyarzun Fernanda X. , Vera Luciano , Bascur Miguel , Guzmán Fabián , Silva Francisco , Urzúa Ángel , Brante Antonio
Published: January 2019

In marine invertebrates, the modes of development at early stages are related to the type and capacity of larval feeding to achieve growth. Therefore, studying the factors that determine larval feeding strategies can help to understand the diversity of life histories and evolution of marine invertebrates. The polychaete Boccardia wellingtonensis is a poecilogonous species that encapsulates and incubates its offspring. This species produces two types of larvae: (1) larvae that do not feed within the capsule and hatch as planktotrophic larvae (indirect development), and (2) adelphophagic larvae that feed on nurse eggs and other larvae inside the capsule to hatch as advanced larvae or juveniles (direct development). Otherwise, the larval types are indistinguishable at the same stage of development. The non-apparent morphological differences between both types of larvae suggest that other factors are influencing their feeding behavior. This work studied the potential role of the activity of 19 digestive enzymes on the different feeding capacities of planktotrophic and adelphophagic larvae of B. wellingtonensis. Also, differences in larval feeding structures and the larval capacity to feed from intracapsular fluid were evaluated by electron and fluorescence microscopy. Results showed that both types of larvae present similar feeding structures and had the capacity to ingest intracapsular fluid protein. Adelphophagic larvae showed overall the highest activities of digestive enzymes. Significant differences between larval types were observed in nine enzymes related to the use of internal and external nutritional sources. Given that larval feeding is closely related to larval development in species with encapsulation, this work supports that the study of the digestive enzymatic machinery of larvae may contribute to understanding the evolution of developmental modes.
Primulina anisocymosa(Gesneriaceae), a new species with a unique inflorescence structure from Guangdong, China
Authors: Hong Xin , Keene Jeremy , Qiu Zhi-Jing , Wen Fang
Published: January 2019

A newPrimulinaspecies from Guangdong, China with an unusual inflorescence is described here.Primulina anisocymosais vegetatively most similar toP. bobaiensis. It can be distinguished from all species withinPrimulinamorphologically by its unique zigzag monochasial cyme and infructescence. To confirm the phylogenetic relationships and generic placement of this species, not only morphological anatomical features but also chromosome and DNA sequence data were examined and analysed here. Two samples from different populations identified asPrimulina anisocymosaare monophyletic and were nested in a monophyletic clade withinPrimulinawith high branch support. The somatic chromosome number of the new species is also reported (2n = 36), supporting its placement in the genus.
Evaluation of posttraumatic stress disorder diagnosis and therapy on diurnal blood pressure patterns from 24-hour ambulatory blood pressure monitoring
Authors: Cave Brandon , Hough Augustus R.
Published: January 2019

Introduction

The veteran population has a high incidence of posttraumatic stress disorder (PTSD), which is associated with increased risk of hypertension and cardiovascular death. Ambulatory blood pressure monitoring (ABPM) can identify abnormal diurnal blood pressure (BP) patterns, which are associated with increased risk of cardiovascular events. The intent of this evaluation was to examine prior ABPM studies to determine whether veterans with PTSD are more likely to have abnormal nocturnal dipping patterns compared with the general veteran population.

Methods

Retrospective chart review was performed on all archived ABPM studies and classified by nocturnal dipping status and BP control rates. Pertinent patient demographics of age, sex, concomitant PTSD, and use of selected PTSD therapies were identified at the time of ABPM study. Association between dipping status, BP control rates, and patient demographics were analyzed using appropriate statistical tests.

Results

A total of 470 ABPM studies were determined to be valid and included. There were no differences in the distribution of nocturnal dipping patterns in veterans with or without PTSD. Likewise, rates of nocturnal, awake, and 24-hour hypertension were similar between groups. In patients with PTSD who were treated with evening PTSD therapy, there was a higher rate of normal dipping status compared with those without treatment (66.7% vs 29.7%, P = .03).

Discussion

Veterans with PTSD had similar distributions of dipping patterns and rates of overall, awake, and nocturnal hypertension compared with the general veteran population. The association of nocturnal PTSD therapy prescription in patients with PTSD and higher rates of normal dipping status may warrant further investigation.
Elements of nursing care for onco-hematology patients: a case study / Elementos do cuidado de enfermagem aos pacientes onco-hematológicos: um estudo de caso
Authors: De Sousa Renata Miranda , Santo Fátima Helena Do Espírito , Santana Rosimere Ferreira , Moreira Marlea Chagas , Pinheiro Fernanda Machado
Published: January 2019

Objetivo: Identificar os elementos do cuidado de enfermagem a pacientes onco-hematológicos internados na hematologia de um hospital universitário localizado no Estado do Rio de Janeiro. Método: Trata-se de um estudo de caso, cuja coleta de dados ocorreu entre fevereiro a junho de 2013 por meio de entrevista semi-estruturada com 10 membros da equipe de enfermagem da unidade e submetidas análise de conteúdo, aprovado pelo CEP sob parecer n° 144.119. Resultados: Apontaram como elemento do cuidado aos pacientes onco-hematológicos os relacionadas a prevenção de sangramento e infecção, conforto, apoio emocional e orientação. Conclusão: Observou-se que tais elementos são essenciais para a manutenção de um tratamento seguro e eficiente destes pacientes não só no ambiente hospitalar, mas também no contexto domiciliar. E precisam ser compreendidos e incorporados por todos os envolvidos para garantir qualidade de vida aos pacientes onco-hematológicos.
Evaluation of the quality of life of chronic renal patients in hemodialysis - a cross-current study / Avaliação da qualidade de vida de pacientes renais crônicos em hemodiálise – um estudo transversal
Authors: Zanesco Camila , De Brito Pitilin Erica , Rossetto Maíra , Tavares de Resende e Silva Débora
Published: January 2019

Objetivo: Caracterizar os pacientes com DRC em tratamento de hemodiálise (HD) de uma clínica do oeste catarinense, suas relações e variáveis sociodemográficas, e, a sua QV. Metodologia: Estudo transversal descritivo, com 116 pacientes com DRC em HD. Para coleta dos dados usou-se questionário sociodemográfico e o intrumento Medical Outcomes Study 36 – Item Short – Form Health Survey (SF-36). Resultados: Houve prevalência da população com idade igual ou > 60 anos, caucasianos (74,77%), do sexo masculino (54,31%), destaca-se a presença de profissões relacionadas a classe média ebaixa e quantidade de anos de estudo reduzidos. Em relação a comorbidades, prevaleceu a Hipertensão Arterial Sistêmica(38,79%). Quanto a QV as limitações por aspectos físicos tiveram menores médias (29,09) e limitações em atividades sociais maior média (73,71). Conclusão: A QV negativa têm repercussões pessoais, familiares e sociais devido ao impacto da doença na rotina de atividades de vida diária dos doentes renais.
Dimensions of the quality of life negatively affected in people living with / Diabetes Mellitus Dimensões da qualidade de vida afetadas negativamente em pessoas vivendo com Diabetes Mellitus
Authors: Alencar Delmo de Carvalho , Filho Patriotino Fontinele Lages , Neiva Maria de Jesus Lopes Mousinho , Alencar Ana Maria Parente Garcia , Moreira Wanderson Carneiro , Ibiapina Aline Raquel de Sousa
Published: January 2019

Objetivo: Avaliar a qualidade de vida relacionada à saúde de pessoas com diabetes mellitus tipo 2 atendidas pela Atenção Primária à Saúde. Métodos: Estudo descritivo, transversal realizado com 50 pacientes diabéticos. Os dados foram coletados por meio da aplicação de um formulário para informações socioeconômicas e clínicas e do Medical Outcomes Study 36-item Short Form Health Survey (SF-36). Os dados foram expressos como frequências absolutas e relativas e medidas de tendência central e dispersão. Resultados: As maiores médias dos escores do SF-36 foram verificadas nos domínios "Capacidade Funcional, Vitalidade e Aspectos Sociais", enquanto as menores concentraram-se nos domínios "Estado Geral da Saúde e Aspecto Físico". Conclusão: A funcionalidade das atividades diárias e a percepção sobre a saúde foram os principais aspectos comprometidos pelo diabetes mellitus tipo 2.
Evaluation of the physical limitations, psychosocial aspects and quality of life of people affected by leprosy / Avaliação das limitações físicas, aspectos psicossociais e qualidade de vida de pessoas atingidas pela hanseníase
Authors: Maranhão Ferreira Silva Paloma , Esteves Pereira Laura , Lima Ribeiro Larissa , Moura dos Santos Danielle Christine , Delmondes do Nascimento Raphaela , Steremberg Pires D'Azevedo Stephanie
Published: January 2019

Objetivo: Avaliar os aspectos referentes as limitações físicas, psicossociais e qualidade de vida das pessoas atingidas pela hanseníase. Método: Estudo quantitativo, transversal. Foram aplicadas as escalas Screening Activity Limitation and Safety Awareness (SALSA), Participação Social e World Health Organization Quality of Life (WHOQOL-bref) com 31 sujeitos. Resultado: Evidenciou-se que a maioria dos participantes apresentava algum grau de restrição física e social. Correlacionando com o grau de incapacidade, destaca-se que os pacientes que apresentaram restrições, também possuíam grau II de incapacidade. Quanto à qualidade de vida, o domínio psicológico e o de relações sociais apresentaram as médias mais altas, enquanto o físico e o ambiental tiveram as mais baixas. Conclusão: Afirma-se a necessidade de priorização e intensificação das ações de prevenção de incapacidades da hanseníase.Descritores: Hanseníase, autocuidado, qualidade de vida.
(Re)discussing the drug administration technique by the intramuscular route: a systematic review / (Re)discutindo a técnica de administração de medicamentos pela via intramuscular: revisão sistemática
Authors: Gomes Barbara Ragasse Pereira , Paes Graciele Oroski , Traverso Fabíola Alves
Published: January 2019

Objetivos:Identificar a produção do conhecimento da enfermagem atrelado a técnica de administração de medicamentos pela via intramuscular; descrever as divergências, congruências, e ocorrência de complicações acerca da técnica; e analisar as recomendações descritas na literatura com as melhores práticas e atualizações clínicas na enfermagem. Método: Revisão sistemática sem meta-análise.Realizada busca nas bases de dados LILACS, Pubmed, Medline, DEDALUS, Portal de Evidência em Saúde e Bibliotecas SciELO e Cochrane, no período de 1993 a 2012,totalizando 16 estudos.  Resultados:Os estudos evidenciaram divergências na variações de demarcação da região ventroglútea; realização de antissepsia; e aplicação de pressão antes da administração intramuscular.Consonâncias na aspiração do conteúdo da seringa após inserção da agulha na massa muscular, rodízio do local de aplicação durante sequências de injeções IM, dentre outros.Conclusão:A incorporação das melhores evidências permite a execução segura da técnica intramuscular, gerando conforto ao paciente e excelência na assistência.
Adolescents coexisting with drug users: experiences in the light of the bioecological model / Adolescentes no convívio com usuários de drogas: vivências à luz do modelo bioecológico
Authors: Guimarães Andréa Noeremberg , Brum Maria Luiza Bevilaqua , Zanatta Elisangela Argenta , Ferraz Lucineia , Motta Maria da Graça Corso da , Schneider Jacó Fernando
Published: January 2019

Objetivo: Conhecer as vivências de um grupo de adolescentes no convívio com usuários de drogas à Luz do Modelo Bioecológico de Bronfenbrenner. Métodos: Pesquisa qualitativa, descritivo-exploratória, desenvolvida de março de 2014 a agosto de 2015, com 30 adolescentes que participam de um Programa de Oficinas Educativas de uma Organização Não-Governamental, em Santa Catarina. Foram realizadas entrevistas semiestruturadas e a interpretação ocorreu conforme a análise de conteúdo. Resultados: Identificaram-se duas categorias: Adolescentes convivendo com usuários de drogas no sistema familiar e Adolescentes convivendo com usuários de drogas no contexto social. Observou-se que microssistema, exossistema, mesossistema, macrossistema e cronossistema influenciam e são influenciados pelo mundo das drogas. Conclusão: É necessário pensar em estratégias de intervenção em saúde, que considerem os sistemas bioecológicos em que os adolescentes estão inseridos. Este estudo pode contribuir para a reflexão e implantação de práticas de cuidado à saúde com adolescentes sobre o uso de drogas pela Enfermagem.
T’sarat/leprosy: paths taken by relatives of former patients treated in the asylum environment / T’sarat/hanseníase: caminhos trilhados por familiares de ex-doentes tratados em ambiente asilar
Authors: Costa Pinheiro Mônica Gisele , Albino Simpson Clélia , Nunes de Miranda Francisco Arnoldo , Parreira Mendes Felismina Rosa
Published: January 2019

Objetivo: Averiguar a compreensão que familiares de ex-doentes de hanseníase tratados em hospitais colônia têm sobre a doença. Métodos: Estudo qualitativo, enfocando a história oral temática. Os 52 familiares de ex-doentes de lepra que foram segregados no Hospital Colônia São Francisco de Assis compuseram a colônia. A rede foi constituída por 10 colaboradores, ambos os sexos, com idade entre 44 a 76 anos. A coleta de dados foi norteada por questões abertas que direcionaram as lembranças dos colaboradores para o propósito do estudo. As entrevistas foram gravadas, transcrita e analisadas pela análise temática de conteúdo. A pesquisa foi aprovado pelo Comitê de Ética em Pesquisa da Universidade Federal do Rio Grande do Norte, CAAE 25922214.3.0000.5537. Resultados: Identificaram-se duas categorias: A história no passado e a A história no presente. Conclusão: Os entrevistados refletiram sobem política de controle da lepra no passado, assim como a adotada no presente frente à hanseníase.
Contributions of Better Childhood for growth and child development in family perception / Contribuições da Primeira Infância Melhor para o crescimento e desenvolvimento infantil na percepção das famílias
Authors: Santos dos Santos Gabrieli , Machado Pieszak Greice , Calcagno Gomes Giovana , Baldicera Biazus, Camila , De Oliveira Silva Silvana
Published: January 2019

RESUMO: Objetivo: conhecer as percepções das famílias atendidas pelo Primeira Infância Melhor acerca de suas repercussões no crescimento e desenvolvimento infantil e no cuidado familial das crianças. Métodos: Estudo qualitativo realizado no domicílio de 15 famílias. Os dados foram coletados por entrevistas semiestruturadas em setembro de 2016 seguida da análise de conteúdo temática. Resultados: identificaram que crescer e se desenvolver são processos que ocorrem em conjunto, reconheceram o apoio dos visitadores, que situações de vulnerabilidade e a troca constante dos visitadores interferem negativamente no crescimento e desenvolvimento infantil, que o programa oportuniza a construção do aprendizado e fortalecimento de um cuidado familial efetivo. Conclusão: Recomenda-se que a enfermagem esteja incluída junto à equipe interdisciplinar, e que o Primeira Infância Melhor seja visualizado na atenção primária como uma estratégia capaz de fortalecer a promoção da saúde e a integralidade do cuidado à criança e sua família.
Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin‐knockout mice
Authors: He Shiyi , Li Junping , Wang Jianxiong , Zhang Ying
Published: January 2019

High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein‐coupled receptor APJ and has possible roles in energy metabolism. Apelin‐null mice have been reported to exhibit impaired insulin sensitivity, which can be reversed by supplementation of exogenous apelin. Here, we examined the effects of 4 weeks’ intermittent hypoxia exposure on physiological and biochemical variables in apelin knockout (KO) mice. Apelin KO mice exhibited decreased expression of substrate metabolism‐associated genes/proteins, impaired glucose tolerance, and reduced exercise capacity compared to wild‐type mice, and all of these effects were rescued by hypoxia. These findings suggest that hypoxia intervention may possibly be able to alleviate metabolic conditions caused by genetic defects.
In Situ Atomic Force Microscopy of the Reconfiguration of On‐Surface Self‐Assembled DNA‐Nanoparticle Superlattices
Authors: Shekhirev Mikhail , Sutter Eli , Sutter Peter
Published: January 2019

The ability to dynamically reconfigure superlattices in response to external stimuli is an intriguing prospect for programmable DNA‐guided nanoparticle (NP) assemblies, which promises the realization of “smart” materials with dynamically adjustable interparticle spacing and real‐time tunable properties. Existing in situ probes of reconfiguration processes have been limited mostly to reciprocal space methods, which can follow larger ordered ensembles but do not provide access to real‐space pathways and dynamics. Here, in situ atomic force microscopy is used to investigate DNA‐linked NP assemblies and their response to external stimuli, specifically the contraction and expansion of on‐surface self‐assembled monolayer superlattices upon reversible DNA condensation induced by ethanol. In situ microscopy allows observation and quantification of key processes in solution, e.g., lattice parameter changes, defects, and monomer displacements in small groups of NPs. The analysis of imaging data uncovers important boundary conditions due to DNA bonding of NP superlattices to a substrate. Tension in the NP–substrate DNA bonds, which can elastically extend, break, and re‐form during contraction/expansion cycles, counteracts the changes in lattice parameter and causes hysteresis in the response of the system. The results provide insight into the behavior of supported DNA‐linked NP superlattices and establish a foundation for designing and probing tunable nanocrystal‐based materials in solution.
Cardiac Fibrotic Remodeling on a Chip with Dynamic Mechanical Stimulation
Authors: Kong Ming , Lee Junmin , Yazdi Iman K. , Miri Amir K. , Lin Yi‐Dong , Seo Jungmok , Zhang Yu Shrike , Khademhosseini Ali , Shin Su Ryon
Published: January 2019

Cardiac tissue is characterized by being dynamic and contractile, imparting the important role of biomechanical cues in the regulation of normal physiological activity or pathological remodeling. However, the dynamic mechanical tension ability also varies due to extracellular matrix remodeling in fibrosis, accompanied with the phenotypic transition from cardiac fibroblasts (CFs) to myofibroblasts. It is hypothesized that the dynamic mechanical tension ability regulates cardiac phenotypic transition within fibrosis in a strain‐mediated manner. In this study, a microdevice that is able to simultaneously and accurately mimic the biomechanical properties of the cardiac physiological and pathological microenvironment is developed. The microdevice can apply cyclic compressions with gradient magnitudes (5–20%) and tunable frequency onto gelatin methacryloyl (GelMA) hydrogels laden with CFs, and also enables the integration of cytokines. The strain–response correlations between mechanical compression and CFs spreading, and proliferation and fibrotic phenotype remolding, are investigated. Results reveal that mechanical compression plays a crucial role in the CFs phenotypic transition, depending on the strain of mechanical load and myofibroblast maturity of CFs encapsulated in GelMA hydrogels. The results provide evidence regarding the strain–response correlation of mechanical stimulation in CFs phenotypic remodeling, which can be used to develop new preventive or therapeutic strategies for cardiac fibrosis.
Recruitment and Collection of Dermal Interstitial Fluid Using a Microneedle Patch
Authors: Kolluru Chandana , Williams Mikayla , Chae Jeremy , Prausnitz Mark R.
Published: January 2019

Interstitial fluid (ISF) that surrounds cells in tissues of the body is a novel source of biomarker that complements conventional sources like blood, urine, and saliva. To overcome difficulties in harvesting ISF, a minimally invasive, rapid, simple‐to‐use, cost‐effective method is developed to collect ISF from the skin involving a microneedle (MN) patch. By pressing 650 µm long MNs at an angle just below the skin surface, blood‐free ISF flows through micropores to the skin surface and is absorbed into a thin strip of paper on the MN patch backing for subsequent analysis. An optimized method in rat skin in vivo is well tolerated and able to collect >2 µL of ISF within 1 min. Brief skin pretreatment with MNs followed by a 5 min delay dramatically increases subsequent ISF collection by a mechanism believed to involve increased skin hydration. ISF collection using an MN patch has the potential to simplify access to biomarkers in ISF for research and future medical diagnostic and monitoring applications.
Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium
Authors: Patel Asha Kumari , Kaczmarek James C. , Bose Suman , Kauffman Kevin J. , Mir Faryal , Heartlein Michael W. , DeRosa Frank , Langer Robert , Anderson Daniel G.
Published: January 2019

Noninvasive aerosol inhalation is an established method of drug delivery to the lung, and remains a desirable route for nucleic‐acid‐based therapeutics. In vitro transcribed (IVT) mRNA has broad therapeutic applicability as it permits temporal and dose‐dependent control of encoded protein expression. Inhaled delivery of IVT‐mRNA has not yet been demonstrated and requires development of safe and effective materials. To meet this need, hyperbranched poly(beta amino esters) (hPBAEs) are synthesized to enable nanoformulation of stable and concentrated polyplexes suitable for inhalation. This strategy achieves uniform distribution of luciferase mRNA throughout all five lobes of the lung and produces 101.2 ng g−1 of luciferase protein 24 h after inhalation of hPBAE polyplexes. Importantly, delivery is localized to the lung, and no luminescence is observed in other tissues. Furthermore, using an Ai14 reporter mouse model it is identified that 24.6% of the total lung epithelial cell population is transfected after a single dose. Repeat dosing of inhaled hPBAE‐mRNA generates consistent protein production in the lung, without local or systemic toxicity. The results indicate that nebulized delivery of IVT‐mRNA facilitated by hPBAE vectors may provide a clinically relevant delivery system to lung epithelium.
Hydrogel Microelectromechanical System (MEMS) Resonators: Beyond Cost‐Effective Sensing Platform
Authors: Yoon Yeowon , Chae Inseok , Thundat Thomas , Lee Jungchul
Published: January 2019

Mechanical resonators have been used for various applications including timing references, filters, accelerometers, and inertial sensors. Mostly, silicon‐based materials have been thought to be ideal considering robustness and stability and thus used to fabricate micro and nanoscale mechanical resonators. When enhanced sensitivity becomes more important than long‐term stability, materials repertoires other than silicon might be better suited. Herein, a novel manufacturing approach is proposed, which rapidly fabricates microelectromechanical system resonators with hydrogel by single UV exposure via dynamic mask and dry‐state “plugging out” sacrificial process where hydrogel structures are defined by spatially modulated UV light. For practical demonstrations, rectangular cantilevers and closed circular membranes are employed for humidity and pressure sensing applications, respectively. The cost‐effective fabrication route suggested herein not only enables rapid prototyping of suspended hydrogel structures outside a cleanroom, but also offers spatially tunable elastic modulus. Most remarkably, sensitivity enhancement resulting from high swelling rate and/or low elastic modulus exceeds stability deterioration, one of the major concerns for polymeric materials. Such exclusive beneficial features, yet demonstrated with any microfabrication materials and methods or their combinations, open a new avenue for photocurable polymeric materials to be used for specific applications as well as fundamental investigations.