bluuebunny/crossref_metadata_2025 huggingface dataset:
Water Activity Regulates CO2 Reduction in Gas-Diffusion Electrodes
Authors: Nesbitt Nathan , Smith Wilson
Published: January 2021

Electrochemical CO2 reduction has recently reached current densities as high as 1 A cm-2, enabled by improving diffusion of CO2 from the gas phase to the electrocatalyst by use of gas-diffusion electrodes (GDEs) and by improving electrolyte ionic conductivity with concentrated hydroxide electrolytes (7 M KOH). Despite such high solute concentrations, the dilute electrolyte assumption is commonly used to evaluate the thermodynamics of the system, specifically reaction equilibrium potential and reaction rate expression. Here we establish a paradigm shift by demonstrating how to properly include the activity of water and solutes and highlighting corrections to associated reaction thermodynamics.
Pulse Dipolar EPR Reveals Double-Histidine Motif Spin-labelling is Robust Against Competitor Ions
Authors: Wort Joshua , Arya Swati , Ackermann Katrin , Stewart Alan J. , Bode Bela
Published: January 2021

Pulse-dipolar EPR is an appealing strategy for structural characterization of complex systems in solution that complements other biophysical techniques. Significantly, the emergence of genetically encoded self-assembling spin labels exploiting exogenously introduced double-histidine motifs in conjunction with CuII-chelates offers high precision distance determination in systems non-permissive to thiol-directed spin labelling. However, the non-covalency of this interaction exposes potential vulnerabilities to competition from adventitious divalent metal ions, and pH sensitivity. Herein, a combination of room-temperature isothermal titration calorimetry (ITC) and cryogenic relaxation-induced dipolar modulation enhancement (RIDME) measurements are applied to the model protein Streptococcus sp. group G. protein G, B1 domain (GB1). Results demonstrate double-histidine motif spin labelling using CuII-nitrilotriacetic acid (CuII-NTA) is robust against the competitor ligand ZnII-NTA at >1000-fold molar excess, and high nM binding affinity is surprisingly retained under acidic and basic conditions even though room temperature affinity shows a stronger pH dependence. This indicates the strategy is well-suited for diverse biological applications, particularly metalloproteins with divalent metal ion cofactors.
Incorporating Fluorescent Nanomaterials in Organically Modified Sol-Gel Materials – Creating Single Composite Optical pH Sensors
Authors: Bartos David , Rewers Morten , Wang Lu , Sørensen Thomas Just
Published: January 2021

Optical sensors hold the promise of providing the coupling between the tangible and the digital world that we are currently experiencing with physical sensors. The core of optical sensor development lies in materials development, where specific requirements of opposing physicochemical properties create a significant obstacle. The sensor material must provide dye retention, while ensuring porosity for analyte transport. The sensor material must provide hydrophobic pockets for dyes to ensure high signal intensity, while remaining fully hydrophobic to measure in water. We have previously reported optical sensors, where we compromised on sensor manufacturing by using a double-layer composite. Here, we report a composite organically modified sol-gel (ORMOSIL) polymer, where polystyrene (PS) nanoparticles (NPs) have been incorporated. This allows all the opposing requirements on optical sensor materials to be fulfilled, and by introducing a hydrophobic reference dye in the fully hydrophobic compartments of the sensor material we show that we can incorporate any hydrophobic fluorophore in this material, even those which are suffering from quenching in water. In this work, PS NPs with 1,13-dimethoxyquinacridinium (DMQA) were immobilized in a composite sol-gel material with pH responsive diazaoxatriangulenium (DAOTA) dyes prior to curing. The multicomponent sensor composite was cured on a polycarbonate hemiwicking substrate, and the resulting fluorescence intensity ratiometric optical pH sensor was shown to have excellent performance. We expect that this type of composite sensor materials will allow the creation of next generation industrial chemosensors.
Enantioselective Conjugate Addition of Catalytically Generated Zinc Homoenolate
Authors: Sekiguchi Yoshiya , Yoshikai Naohiko
Published: January 2021

We report herein an enantioselective conjugate addition reaction of a zinc homoenolate, catalytically generated via ring opening of a cyclopropanol, to an α,β-unsaturated ketone. The reaction is promoted by a zinc aminoalkoxide catalyst generated from Et2Zn and a chiral β-amino alcohol to afford 1,6- diketones, which undergo, upon heating, intramolecular aldol condensation to furnish highly substituted cyclopentene derivatives with good to high enantioselectivities. The reaction has proved applicable to various 1-substituted cyclopropanols as well as chalcones and related enones. The chiral amino alcohol has proved to enable ligand-accelerated catalysis of the homoenolate generation and its conjugate addition. Positive nonlinear effects and lower reactivity of a racemic catalyst have been observed, which can be attributed to a stable and inactive heterochiral zinc aminoalkoxide dimer.
EXPRESIÓN DE P53 EN CULTIVO DE CÉLULAS MADRE AISLADAS A PARTIR DE QUISTE RADICULAR INFLAMATORIO
Authors:   Universidad Continental, Arequipa - Perú, Jácobo Valdivia Francis Wendell , Bernabé Ortiz Julio Cesar ,   UNIVERSIDAD CATOLICA DE SANTA MARÍA, Valero Quispe Javier ,   UNIVERSIDAD CATOLICA DE SANTA MARÍA, Palomino Valverde Ivo ,   UNIVERSIDAD CATOLICA DE SANTA MARÍA, Muñoz Del Carpio Toia Agueda Rossangella ,   UNIVERSIDAD CATOLICA DE SANTA MARÍA
Published: January 2021

The inflammatory root cyst is defined as one of the most frequent inflammatory lesions in the oral cavity where it normally involves the apex of the dental roots, giving frequent pathognomonic clinical and radiological characteristics. The objective of this investigation was to determine the expression of p53 in the culture of isolated stem cells from the inflammatory root cyst. In its methodology, the report of a case of a 69-year-old patient was presented, who underwent surgical intervention to extract pieces 11 and 12, from which the sample was obtained for the isolation and culture of the cyst stem cells. periapical inflammatory, obtaining elongated, flat cells with fibroblastic appearance from day 4 and staining with markers for p53 giving a positive response in the evidence of the p53 gene both in the cytoplasm and in the nucleus of these stem cells. Finally, cells can be obtained from the inflammatory root cyst from 4 to 25 days with the use of a modified protocol, in the end, as a contribution to this article, the evidence of the p53 gene is provided both in the nucleus and in the cell cytoplasm. Keywords: Root cyst, p53 gene, stem cells, isolation and culture
Diálogos Pertinentes - jul./dez.
Authors: Borges Marilurdes Cruz
Published: January 2021

Revista científica de Letras
“POLÍCIA” e “FARDADO” As relações dialógicas frente à força policial no Brasil
Authors: Oliveira Cláudia De Fátima , Ludovice Camila De Araújo Beraldo
Published: January 2021

O objetivo deste artigo é promover, a partir da análise das letras das canções “Polícia” e “Fardado”, da banda paulistana Titãs, uma reflexão acerca do diálogo entre as letras que, embora construídas em épocas diferentes, trazem à tona questionamentos históricos, políticos e sociais, frente a uma ideologia permanente sobre a força bruta da polícia, instituição regida pelo Estado. Sob a ótica bakhtinana, operam-se análises dialógicas entre as letras e com o contexto histórico, social e cultural do Brasil em épocas distintas, a fim de se demonstrar que vivemos sob uma opressão estatal que se origina da castração e do imperativo, advindos da égide da violência, quer seja em âmbito coletivo, quer seja individual, enunciando um medo social que se faz presente na subjetividade hodierna.
SPOTTED: Comunidades de Namoro no Facebook
Authors: Lima Lopes Rodrigo
Published: January 2021

Este artigo tem por objetivo discutir os processos de interação em comunidades Spotted no Facebook. Tais comunidades têm por objetivo promover a conexão entre indivíduos à moda de um sítio ou aplicativo de namoro (online dating), utilizando, todavia, recursos de uma mídia social aberta. A análise aqui realizada se baseou na Linguística Sistêmico-Funcional (HALLIDAY, 1978), na Ciência das Redes (BARABÁSI, 2002; SCOTT, 2013; WATTS, 2004) e na Comunicação Mediada por Computador (HERRING, 1996) de forma a lançar um olhar qualitativo e quantitativo sobre tais comunidades. A coleta de dados contou com ferramentas de raspagem de dados automatizados, sendo o processamento realizado por meio de softwares como Gephi. Foram estudadas as ligações de tais comunidades no Facebook, de forma a compreender como suas conexões de rede representam suas práticas sociais online e off-line. Procurou-se também compreender qual a estrutura básica de suas postagens, de forma realizar um levantamento dos modos de linguagem (KRESS, 2010) utilizados. Os resultados refletem os processos de socialização e interação.
WILHELM AND ALEXANDER VON HUMBOLDT IN THE HISTORICAL MEMORY OF NAZI GERMANY
Authors:   Russian State University for the Humanities, Rostislavleva Natal'ya V.
Published: January 2021

The article examines the perception of biographies and heritage of the brothers Wilhelm and Alexander von Humboldt in National Socialist Germany. In the historical memory of modern Germany, their images have become one of the bases of German national identity, and the Humboldt-Forum – a platform for the connection of science and culture. In collective memory of the Third Reich, the brothers held unequal positions. The 100th anniversary of the death of W. von Humboldt caused a surge of interest in him, but his image was reformatted and inscribed in the racial parameters of Nazism: his interest in the issues of the German nation was emphasized, his commitment to liberal ideas was explained by criticism of absolutism, attempts were made to attract his image to Nazi anti-Semitic paradigm. However, there were some researchers of his heritage who retained scientific objectivity. Alexander von Humboldt was paid much less attention: the ideologists of the Third Reich hated his cosmopolitanism. But as he was the brother of W. von Humboldt and a world-famous scientist, it was impossible to forget about his merits. The collective memory kept an image of a traveler naturalist whose greatness the Third Reich did not deny. Commemoration is closely associated to the identity formation. For the construction of national identity in National Socialist Germany their images were practically not required.
BOOK REVIEW: MEDUSHEVSKII, N.A. (2019), THOUGHTS ABOUT THE POLITICS OF MEMORY, [S. L.]. IZDATEL'SKIE RESHENIYA, RUSSIA
Authors:   Russian State University for the Humanities, Galdilov Grigorii D.
Published: January 2021

The review considers the book by N.A. Medushevskii the doctor of political sciences, associate professor in the department of the peace and democracy culture with RSUH. The monograph combines six works of authorship devoted to the problematic of historical memory and its political interpretation.
5TH ANNIVERSARY OF THE PATRIOTIC WAR OF 1812. PRACTICES OF COMMEMORATION
Authors:   Russian State University for the Humanities, Ulanov Philipp I.
Published: January 2021

This article examines the commemoration practices in marking 5th anniversary of the Patriotic war of 1812. Those celebrations became actually the first commemorative event dedicated to that war. A historical analysis is based on the material of mass media and memoirs of contemporaries. The focal point of the article is the collective memory formation process: what ceremonies were carried out and what goals were pursued by the state, what were the narratives of historical memory that existed in the press. The study of historical memory and its formation means, and specifically with regard to the anniversaries of the Patriotic war of 1812, has become widely prevalent in modern Russian historiography. However, historians rarely focus their attention on the 5th jubilee of the war. The study of that event from the point of view of the memorial history problematic will reveal not only the emerging of the narratives of historical memory, but also will be the starting point in the further study of their evolution and changes. The study of that dynamics is extremely important, because using the memory of the Patriotic war of 1812 has contributed to forming the national identity and self-consciousness of the Russian population over the past two centuries.
PHENOMENON OF BIG DATA DIPLOMACY IN WORLD POLITICS
Authors:   Saint Petersburg State University, Tsvetkova Natal'ya A. , Kuznetsov Nikita M. ,   Saint Petersburg State University
Published: January 2021

In 2015, the attention of Western researchers was attracted by the concept introduced by Timothy Dye, the American political scientist, who described Big Data analysis as an invaluable resource for the foreign policy of states. Its relevance is evident as in 2020 the methods of data collection, processing, and usage in the projects of digital diplomacy were successfully implemented by the governing bodies in the United States, Russia, China, Iran, Brazil, and others. Thanks to the interest of the countries in Western Hemisphere, Asia, and Europe in the development of artificial intelligence (AI),thistrend issure to take a global character. Some authors consider this advancement of digital diplomacy to be a promising leap into the future, but others – a huge threat to cybersecurity around the world. The purpose of this article is to study a new technology for the development of foreign policy influence called (Big) Data Diplomacy through the analysis of the publications of authoritative scholars and experts from the United States. The American experts are the first drivers for the introduction of the Big Data Diplomacy to word politics. Therefore, the present paper examines the expert community’s views on the Data Diplomacy and reveals the essence, functions, qualitative characteristics, and the main challenges emanating from this new digital instrument in relation to the foreign policy of various countries. In conclusion, we have formulated the general conclusions regarding the vision of the concept of Data Diplomacy and its impact on world politics.
NATIONAL SECURITY CHALLENGES OF THE RUSSIAN FEDERATION IN THE ARCTIC REGION
Authors:   Russian State University for the Humanities, Anisimov Pavel A.
Published: January 2021

The article examines the main challenges to the national security of the Russian Federation in the Arctic region. In particular, the author analyzes the reasons for the behavioral patterns of Russia and the NATO countries in relation to the Arctic through the prism of a realistic paradigm in the theory of international relations. It is the comprehensive approach to the consideration of the Arctic situation that determines the novelty and relevance of the study. In connection with the discovery and development of large mineral deposits, the role of the Arctic region in modern world political processes has increased. Also, since the late 20th – early 21st century, the Arctic has been in the focus of increased attention of international actors due to its geopolitical importance. All this makes it a priority for Russia. The intensification of the economic activity of the Russian Federation in the Arctic, as well as the implementation of such projects as the Northern Sea Route, has become the cause of the growing tensions in the region. The United States and other NATO countries, whose geopolitical interests are affected, are not only strengthening their anti-Russian rhetoric, but also increasing their military presence. In turn, this is perceived by the Russian side as a strategic threat and leads to mirror measures, including the deployment of a military infrastructure and an increase in the number of military exercises. However, despite growing tensions in the Arctic, Russia has consistently demonstrated its readiness for open dialogue and cooperation with its Western partners.
ISSUES IN HEALTHY AGEING AMONG AFRICAN RURAL WOMEN
Authors: C. N. Prof. OkonkworOby
Published: January 2021

Life expectancy has increased considerably and people are continually getting aware of the need to stay young, healthy, active and alive. In order to achieve these as one ages, we need to adopt a healthy life style and diet suitable for each stage of later life. The African culture has its uniqueness due to many factors including the extended family system (EFS) where one is totally dependent on the off-spring and relatives at old age. On the other hand women generally live longer than men thereby creating a situation that provides more old women and widows in the society. Furthermore, the same African culture (like the Igbos of Nigeria) do not encourage old widows to remarry or socialize, thereby placing more economic, socio-psychological and health challenges on the aged women especially in the rural setting where the younger ones have abandoned their villages to migrate to urban areas. The purpose of this paper is to discuss the issues of healthy aging among the African rural women.  It is never too early or too late to work for healthy aging. Therefore, the health, social, psychological, economic and emotional aspect of life-style adjustment for aging .gracefully and happily shall be discussed. The paper ends with functional recommendations as strategies to equip individuals with useful skills for healthy, happy, active life as one ages.
INTELLIGENT ANALYZER FOR UNATTENDED OBJECT DETECTION
Authors: Khadse Rutuja Y. , Lokhande S.S. , Koti S.A.
Published: January 2021

In recent year’s surveillance system have become more popular in the field of computer vision. An object which is left at a particular place under surveillance and unattended over a period of time is called unattended object. Places like airports, railway stations, big shopping malls etc. where there is potentially high security threat detecting unattended object is a very important. The main aim of project is to develop intelligent vision based analyserbased on MATLAB using Image processing for unattended object detection.The detection is based on a simple mathematical model and works efficiently. The pre-processing involves a dual-time background subtraction algorithm which dynamically updates two sets of background, one after a very short interval and the other after a relatively longer duration. The framework of the proposed algorithm is based on the Approximate Median model.
A REVIEW OF STUDY AND ANALYSIS OF PARTIAL DISCHARGE FOR DIFFERENT INSULATION MATERIALS WITH CAPACITANCE VALUE
Authors: Baghelkar Neetu , Dubey Abhishek
Published: January 2021

In the high voltage (HV) electrical power system, a variety of solid, liquid and gaseous materials are used for insulation purposes to protect incipient faults within the HV power equipment. Among these, solid insulation is widely used for high voltage equipment in high voltage power systems. Most insulation materials are not perfect in all respects and always contain some impurities. In high voltage (HV) electrical equipment, the quality of the insulation plays a very important role. Continued growth in the power system has provided the opportunity to protect equipment for healthy operation throughout its useful life.
In Silico Analysis of Antiviral Activity of Analog Curcumin Compounds
Authors: Mulatsari Esti , Martati Titiek , Mumpuni Esti , Dewi Nidya Luciana
Published: January 2021

Some studies state that curcumin analog compounds can improve the bioavailability and biological activity of curcumin. One of the methods to predict the bioactivity of curcumin was computational using molecular docking method. This study has done bioactivity tests of curcumin analog compounds as antiviral using the molecular docking method with the software used are PLANTS, YASARA, MarvinSketch, and Pymol for visualization. This study used analog curcumin compounds derived from previous research. This study used five different viral reseptor types. The maraviroc, docosanol, ribavirin, and zanamivir were used as compound control in this research. The validated target protein consists of 5 (five) receptors with PDB codes 1V2I, 4WEG, 2HWI, 2QAD, and 3ALP. Based on this research, compounds that are predicted active as antiviral on each receptors that are: 2,5-bis(3,5-ditertbutyl-4-hydroxy benzyl)cyclopentanone (1V2I), 1,7- diphenyl-1,6-heptadiene-3,5-dione (4WEG), 1,7-bis(3,4-dibenzyloxiphenyl)-1,6-heptadiene-3,5-dione (2HWI), and 2,5-bis(3,5-ditertbutyl-4-hydroxybenzyl)cyclopentanone (3ALP).
RETRACTION NOTICE TO: Uji Aktivitas Ekstrak Bunga Telang (Clitoria ternatea L.) Sebagai Agen Anti-Katarak
Authors: Eny Kusrini  , Dewi Tristantini  , Ni’matul Izza
Published: January 2021

​Artikel dengan judul Uji Aktivitas Ekstrak Bunga Telang (Clitoria ternatea L.) Sebagai Agen Anti-Katarak telah dilakukan pencabutan dari Jurnal Jamu Indonesia Vol. 2 No. 1 (2017), pada tautan daring http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/28.Pencabutan artikel dilakukan karena permintaan author.Pemberitahuan pencabutan dari artikel tersebut dapat ditemukan pada http://jamu.journal.ipb.ac.id/index.php/JJI/article/view/225.
Density of surgical specimens and correlation with clinical characteristics of women submitted to mastectomy: the archimedes project
Authors: Cardoso Cassio , Silva Mariana Sousa Sguerra , Rabelo Ana Gabriela Bicalho , Santos Cesar Cabello dos , Duarte Giuliano Mendes
Published: January 2021

Introduction: Breast cancer is the second most common neoplasm among women, being responsible, per year, for 60 thousand new cases of breast cancer in Brazil. The treatment varies according to staging, and mastectomy is indicated in cases in which conserving surgery it is not possible. Mastectomy patients who do not present with indication for breast surgical reconstruction may have self-esteem problems, and external prostheses are one of the means to recover body image. Despite being an external, relatively simple device, external prosthesis may lead do pruritus, pain, paresthesia and postural changes. Therefore, the objective of this study is to describe the density of the female breast to serve as a base to improve these prostheses, considering that the current literature lacks studies to establish this parameter. Objectives: To determine the density of the female breast and correlate it with the clinical and epidemiological characteristics and the treatment. Subjects and Methods: This is a descriptive study that measured the mass and volume of 100 mastectomy specimens to calculate density, with correlation to factors such as age, parity, menstrual factors. Determination of frequencies, means and standard-deviation of the variables, with risk assessment, was carried out with the chi-square or the Fisher’s exact test for the expected values lower than 5, as well as the log-binomial model between the variables using the prevalence ratio with 95% confidence interval (GraphPad®, available at https://www.graphpad.com/quickcalcs/contingency2/). We considered p<0.05 as significant, and confidence intervals (CI) were established at 95%. Results: Of the 100 women included in this study, 78% were white, mean age was 58 years (300‒94 years), mean age at menarche was 13 years, and mean age at menopause was 49 years. Of the women submitted to mastectomy, 39% were in their reproductive years. Mean density of the mastectomy specimens in this study was 1.23g/cm3. There was statistically significant correlation regarding the difference in the density of the specimens in patients with Body Mass Index (BMI)>30 in relation to the density of the specimens in patients with BMI<30. In this aspect, we found lower density associated with BMI>30 (p=0.0025). Conclusion: unlike what we found in the literature, the mastectomy specimens are approximately 20% denser in relation to water and silicone, which are commonly used materials in internal and external prosthesis. This reference can collaborate with the development of prosthesis that are more similar to the natural breast, better adjusting to the daily life of women, with fewer side effects and better quality of life.
Indicatons for adenomastectomy in the past 10 years: what has changed the decision of the surgeon?
Authors: Sonagli Marina , Bertolli Eduardo , Iyeyasy Hirofumi , Makdissi Fabiana Baroni Alves
Published: January 2021

Introduction: Adenomastectomy (AM) consists of the almost complete removal of the mammary gland, but preserving the skin envelope and areolar-papillary complex (APC). This technique was initially indicated to women with family history of breast cancer and for treating fibrocystic breast disease. Currently, it can be carried out in a prophylactic manner in patients with genetic mutations associated with higher risks of breast cancer, and in a therapeutic manner for the treatment of tumors smaller than 3 cm, which are peripheral or more than 2 cm away from the APC, with negative retroareolar margin intraoperative freezing. Among the advantages of keeping the APC in AM are the cosmetic results, which favor self-image and self-esteem. Objectives: to assess the incidence of prophylactic AM (PAM) and therapeutic AM (TAM) and relate the PAM with the presence of family history of neoplasms, genetic changes that present high risk for breast cancer or desire of the patient (absence of these criteria). Methods: retrospective study of patients submitted to AM at A.C. Camargo between 2007 and 2017. Results: two-hundred and ninety patients were included, of which 77 were submitted to bilateral AM (154 AM), and 213 patients, to unilateral AM, accounting for 367 AM. Between 2007 and 2009, 116 PAM and 20 TAM were performed; between 2010 and 2013, 40 PAM and 32 TAM; and between 2014 and 2017, 71 PAM and 88 TAM. The indications of PAM were: between 2007 and 2009, 7 PAM were owed to pathogenic mutations, 50 were due to “family history of high risk”, and 58 due to the patient’s desire; between 2010 and 2013, 14 were caused by pathogenic mutations, 12 by “family history of high risk”, and 14 by the patient’s desire; between 2014 and 2017, 45 were owed to pathogenic mutations, 18 to “family history of high risk”, and 8 to the desire of the patient. Conclusions: it is observed that between 2007 and 2017 there was a progressive increase in the incidence of TAM, especially after 2010; simultaneously, there was a reduction in PAM, and they were finally equivalent in 2017. It is possible to observe that the reduction in the incidence of PAM in the first triennium was owed to the reduction in indications of PAM, based only on family history or on the patient’s desire. The recapture of PAM occurred with the increasing number of diagnosis of hereditary syndromes. At the end of the decade, most of the PAMs were performed due to the presence of pathogenic mutations, as advised by NCCN®.
Immediate breast reconstruction with definitive pre-pectoral prosthesis after nipple sparing mastectomy through inframammary fold without using an acellular matrix: result of 13o cases
Authors: Fornazari Alessandra Amatuzi Cordeiro , Nissen Leonardo Paese , Kuroda Flavia , Dória Maíra Teixeira , Urban Cícero de Andrade
Published: January 2021

Introduction: Breast reconstruction with prosthesis after mastectomy is currently the main reconstruction technique used in the world. The pre-pectoral prosthesis is progressively being more used, and has advantages in relation to the submuscular prosthesis, such as less pain in the postoperative period, decreased muscular deficit, breast animation, better aesthetic result, besides reducing the time of surgical morbidity, for being easier to execute. Objectives: To review the results and complications of patients submitted to breast reconstruction with definitive prosthesis without using an acellular matrix (ADM). Methods: Retrospective study including patients who underwent immediate reconstruction with pre-pectoral definitive prosthesis after nipple sparing mastectomy (NSM), with incision through the inframammary fold (IMD), without using ADM, between January, 2018, and July, 2019. We collected demographic data, types of therapy and surgical data. The complications and secondary surgical interventions were also assessed. The Fisher’s Exact Test was used for statistical analysis (p lower than 0.05). Results: During the study period, 130 reconstructions were performed in 87 patients. Mean age was 43 years. Thirty two mastectomy procedures (24.6%) presented at least one complication, and the most common ones were: flap necrosis (N=13), persistent seroma (N=10), and prosthesis exposure (N=9). Of this total, 21 were submitted to a new surgical procedure, and 12 (9.2%) evolved with loss of prosthesis in an average of 64 days (12 to 180 days) after the first surgery. The main risk factors associated with loss of prosthesis were smoking (OR 4; 1.48‒10.8) and BMI higher than 25 (OR 4.4; 1.24‒15.6), both with statistical significance (p<0.05). The presence of previous radiotherapy (42.8% x 21.5%) or adjuvant therapy (37.5% x 21.5%) and diabetes mellitus (42.9% x 23.6%) show a tendency to higher chances of complications, however, these were not statistically significant. The other assessed factors did not present correlation with the complications. Regarding the late aesthetic result, we only assessed the patients who were followed up for more than 6 months. Of the 52 breasts, 69.3% did not present capsular contracture, and 28.8% presented contracture in Grades I or II of the Baker scale. Rippling was identified in only 13 breasts (25%). There was no prosthesis dislocation or breast animation. Conclusion: Breast reconstruction with definitive pre-pectoral prosthesis after NSM using IMD is a promising, safe and economically advantageous technique, presenting results and complications similar to the cases that use ADM or place the retromuscular prosthesis.
Gestational gigantomastia: A case series
Authors: Pasetto Camila Vitola , Costa Natalia de Souza , Nascimento Isabela do Prado , Weffort Marcos Daniel , Budel Vinicius Milani
Published: January 2021

Introduction: Gestational gigantomastia (GG) is a rare condition known for the massive growth of one or both breasts during pregnancy. Objectives: to describe three cases of GG in patients assisted Hospital de Clínicas do Paraná. Case Reports: Case 1 ‒ Twenty-four year old pregnant woman, of 9 weeks, presented with mastalgia and increasing breast volume associated with phlogistic signs and orange peel-like skin. Breast ultrasound showed diffuse inflammatory process. A biopsy was performed and showed ductal ectasia and stromal fibroadenomatoid changes. On the 20th week, she was hospitalized with fever, voluminous breasts and drainage of purulent secretion and long ulcers in the inframammary fold. She was administered antibiotics and local care. The choice was to interrupt the pregnancy of 33 weeks. She presented with relative reduction of the breasts and breastfed, but had severe psychological problems caused by the aesthetic dissatisfaction. Case 2 ‒ Eighteen-year old patient presented with infiltrating ductal breast carcinoma in the right breast, treated with sectorectomy, with sentinel lymph node and conventional radiotherapy. After one year of follow-up, ductal carcinoma in situ (DCIS) was diagnosed in the left breast, being submitted to sectorectomy and intraoperative radiotherapy. Two years after DCIS, she became pregnant and presented with GG only in the left breast, with remarkable asymmetry and skin edema. After the Cesarean section, breastfeeding was normal on the GG side, but not on the right side, due to a sequel from total radiotherapy. Case 3 ‒ Twenty-two year old pregnant women, of 12 weeks, presented with mastalgia and exaggerated growth of the breasts, with and orange peel-like skin. Breast ultrasound showed bilateral inflammatory process. On the 15th week, she presented with bleeding ulcers, right breast with latero-lateral diameter of 48 cm, and craniocaudal diameter of 56 cm, and left breast with 49 cm and 58 cm, respectively. Due to the fast and progressive growth of the breasts, with difficulties to breath, major venous and lymph stasis and extensive skin ulceration/maceration, with risk of infection, the patient and relatives agreed on conducting a therapeutic abortion, followed by a reduction mammoplasty. Discussion: It is a rare disease, and its etiology remains unknown. Medicinal therapy seems to be first option, but it is often necessary to complement it with a surgical procedure. Conclusions: GG is a pathology of great morbidity, with tendency to recede in the puerperium. In case it is not possible to wait, the recommendation is to intervene in the pregnancy.
Case report: Liposarcoma of the breast in a man
Authors: Medeiros Marina Fontes , Paim Soraya de Paula , Sales Rachel Saraiva Teatini Selim de , Melo Thássia Mariz de , Ferreira Janaina Cotta Rodrigues
Published: January 2021

Introduction: Sarcomas are a heterogeneous group of malignant neoplasms and represent less than 1% of neoplasms among adults; 80% of these cases originate in soft tissues. The liposarcoma corresponds to 20% of the subtypes of sarcoma in adults. Objectives: To present a rare case of liposarcoma of the breast. Methods: We studied the case of A.N.R, a 54-year old male patient, from Belo Horizonte, Minas Gerais, presenting a progressive growth nodule in the right breast. Mammography and breast ultrasound suggested lipoma. Core-needle biopsy of the nodule in the right breast was performed, and the anatomopathological was compatible with lipoma. Case report: Due to the progressive growth, the patient was submitted to nodule resection, with safety margins. Anatomopathological and immunohistochemical of the surgical piece were compatible with well-differentiated liposarcoma. The patient was followed-up by the oncologist and had a staging computed thoracic and abdominal tomography without changes, thus not indicative of adjuvant treatment. Discussion: Liposarcoma presents as a painless mass, of progressive growth, being more common in extremities and the retroperitoneum. When the well-differentiated morphological subgroup is located in the extremities and the torso, its excision is curative, and its metastatic potential is null in comparison to other locations; however, it is not recommended to underestimate the risk of local recurrence. Conclusion: even though the prevalence of benign lesions in soft tissues is higher than malignant lesions, it is important to consider a differential diagnosis of malignancy when the behavior and presentation of the tumor are atypical (deep location to the muscle fascia, larger than 5 centimeters, progressive growth), therefore leading to better surgical and therapeutic planning and to a more accurate treatment for the patient.
Idiopathic granulomatous mastitis: Literature review and retrospective analysis of the sample at hospital federal da lagoa from 2013 to 2017
Authors: Medeiros Michele Catucá , Machado Rafael Henrique Szymanski
Published: January 2021

Introduction: Idiopathic Granulomatous Mastitis (IGM) is a benign inflammatory, rare and chronic condition. It constitutes about 24% of all breast inflammatory diseases, and its recurrence ranges from 16% to 50%. Its etiology was not completely elucidated. Breastfeeding and local trauma can be present. Other hypotheses include the use of oral contraceptives, hyperprolactinemia, smoking, infection, autoimmune diseases and alpha 1 antitrypsin deficiency. Objectives: To analyze data from patients in Hospital Federal da Lagoa diagnosed with IGM, and compare the results with the literature. METHOD: We conducted a retrospective analysis of the medical charts in Hospital da Lagoa, Rio de Janeiro, between 2013 and 2017, and identified 15 women, aged between 21 and 76 years, with IGM. RESULT: Of the 15 patients, 14 (93.3%) were tested for mastitis caused by common germs and Koch’s bacillus. Thoracic x-ray, PPD and culture were performed, and one patient tested positive for BK. Of the 14 patients with negative result for secondary infection, one was pregnant, one had HIV, and the other 12 (85.7%) did not present any specificities. At physical examination, 10 women (66.6%) had ulcer, 9 (60%) had a palpable nodule. Eleven patients (73.3%) had undergone an ultrasound, 5 (45.4%) with BIRADS 4; 4 (36.3%) with BIRADS 3; one patient (9%), BIRADS 2, and two (18.1%), BIRADS 1. In the mammography of the first appointment, 7 (46.6%) had records int he medical chart. Three (42.8%) with BIRADS zero; 2 (28.5%), BIRADS 3; one (14.3%), BIRADS 4, and another one (14.3%), BIRADS. Six patients were submitted to some surgical treatment (40%); regarding medicine treatment, 10 patients had records. One (10%) received RIP scheme; 4 (40%) received antibiotic therapy; two (20%), a combination of antibiotics and corticoids (oral); one (10%), a combination of methotrexate with topic and oral corticoid; two (20%, topic corticoid. Conclusion: By comparing the medical charts’ review with the literature, the results regarding clinical presentation, diagnosis and treatment are similar. The histopathological study is gold standard for diagnostic confirmation, and the medicinal conduct with regular follow-up is the best treatment.
Videolaparoscopic propylactic salpingo-oophorectomy: initial experience
Authors: Vieira Sabas Carlos , Fontinele Danilo Rafael da Silva
Published: January 2021

Introduction: The BRCA mutation substantially increases the risk of ovarian cancer, from 20% to 60% when the mutation is in BRCA1, and 10% to 20% in BRCA1. Bilateral salpingo-oophorectomy may be the most important intervention in these patients, with clear impact on the reduction of mortality caused by ovarian cancer, and about 85% to 50% of reduction in the incidence of breast cancer. Salpingo-oophorectomy should be performed from the ages of 35 to 40 in patients with BRCA1 mutation, and after the age of 40 for BRCA2 carriers. Objectives: To present our initial experience of prophylactic bilateral salpingo-oophorectomy in patients with BRCA mutation. Method: This is a retrospective study. We included all patients who had tested positive for the BRCA mutation assisted from 1999 to 2019. Seven patients were identified with BRCA mutation and underwent videolaparoscopic salpingo-oophorectomy. The procedure was classic. The pieces were removed in endobags and sent to histological analysis with serial sections. The study was approved by the Research Ethics Committee, report n. 2.817.502. Results: No tumor was found in the surgical piece. The mean age of patients when they underwent surgery was 45.8 years. The patients, together, added 21 cases of breast cancer and 4 cases of ovarian cancer among 1st, 2nd and 3rd degree relatives. Five (71.4%) patients presented with BRCA1 mutation. Three patients had been diagnosed with breast cancer, none with previous ovarian cancer. As to the surgery: 3 (42.8%) also underwent bilateral or contralateral risk-reducing mastectomy with reconstruction, and 4 (57.2%) only underwent bilateral salpingo-oophorectomy. All patients are alive and without an active oncologic disease, with mean follow-up of 32 months. Conclusions: In this sample, we did not find any occult tumor in patients submitted to bilateral salpingo-oophorectomy due to BRCA mutation.
Physical and functional complications after surgical treatment for breast cancer
Authors: Estevão Amanda , Haddad Cinira Assad Simão , Rizzi Samantha Karlla Lopes de Almeida , Nazário Afonso Celso Pinto , Facina Gil
Published: January 2021

Introduction: The ideal treatment for breast cancer should be carried out by a multidisciplinary team, aiming at the global approach of the patient. It is usually a prolonged process and can cause relevant changes in the lives of patients, such as limited shoulder movement, pain, lymphedema, adherence scarring, sensitive changes, phlebitis, among others. Physical therapy intervention plays an essential role and can prevent and minimize complications, besides enabling functional recovery. It is extremely important that the physical therapy service is aware of the prevalence of the main physical and functional complications and the impact of its intervention. Objective: To assess the main physical and functional complications in the post-surgical treatment of breast cancer. Methods: This is a cross-sectional study in which we analyzed the medical records of patients treated in the Physical Therapy Ambulatory from 2011 to 2016. We obtained data about the surgery, prevalence of pain, changes in perimeter, movement amplitude, evaluation of scapulohumeral rhythm and presence of axillary cording. Results: We assessed the data of 703 patients, whose mean age was 56 years; 50.1% were married, and body mass index pointed to overweight (mean: 26.8kg/m²). Sedentary lifestyle was prevalent (73.7%). The main surgery performed was quadrantectomy, followed by mastectomy. Pain was present, however, in extremely low levels (mean of pain in the Visual Analog Scale on the seventh postoperative day was 2.55); movement amplitude restrictions were higher in the beginning, and functionally reversed during follow-up; scapular dysfunction is also little prevalent (9.9%), with high percentage of long term resolution. The incidence of axillary cording was high (87.9%), which requires special attention. Conclusion: The study allowed to observe the main physical and functional complications after breast cancer treatment, and show the importance and necessity of early physical therapy.
Management of hypocalcemia after modified bilateral radical neck dissection followed with total thyroidectomy: a case report
Authors: Arimbawa I Made , Paramita Ayu Diah Perdana , Nuaba I Gde Ardika , Saputra Herman
Published: January 2021

Hypocalcemia is a common complication after total thyroidectomy due to acute hypoparathyroidsm post-surgery. The incident varies from 7%-69% depends on the surgery center. The management is divided based on the onset and symptoms. Carpal-pedal spasm, seizure, bronchospasms are the emergency symptoms of hypocalcemia that require administration of   intravenous calcium. However the management of asymptomatic hypocalcemia with oral calcium, vitamin D and hydrochlorothiazide can be difficult due to wide fluctuations of serum calcium and the risks of complication. Hereby we report a 14-year-old girl with hypocalcemia due to hypoparathyroidsm post modified  bilateral radical neck dissection and total thyroidectomy. She had papillary thyroid carcinoma and lymph node metastases. After surgery, she developed classic sign of hypocalcemia,  numbness in extremities which progressed to cramps. Physical examination revealed chvostek’s sign. Laboratory examination showed critical value of hypocalcemia with normal level of albumin, hypoparathyroidsm and hypovitaminosis D. The initial treatment was started by giving  intravenous calcium gluconate 10% and calcitriol. Monitoring level of calcium and phosphate were performed regularly. Calcium level was maintained by giving high dose of elemental calcium, vitamin D3 and hydrochlorothiazide followed.
Reading literacy and periphrastic capacity in the context of individual language development
Authors: Arkhipova E. V. , Lagunova L. V.
Published: January 2021

The aim of the study was to develop linguistic and methodological theoretical aspects of training the skill of paraphrasing, which constitutes an important element of reading literacy. To this end, the authors reviewed research and educational publications in the field of teaching the Russian language and conducted a pedagogical experiment to analyse pedagogical processes. Interrelation between the infosphere and axiosphere of Russian language lessons within the pedagogical discourse involves the division of didactic texts into informational and axiological, including modern linguistic and ethnographic texts that manifest Russian cultural concepts in the new information age. It is shown that various aspects of teaching paraphrasing and interpretation techniques on the basis of informational texts have already been elucidated quite efficiently. However, formation of the axiological component of reading literacy (teaching to paraphrase on the basis of linguo-ethnographic texts) has been undertaken within the framework of the present study for the first time. These issues should be considered comprehensively, in the context of language and values-based development of a personality.
EVALUATION OF SELECTED TECHNICAL PROPERTIES OF BITUMEN BINDERS MODIFIED WITH SBS COPOLYMER AND CRUMB RUBBER
Authors: PAKHOLAK RAMAN , PLEWA ANDRZEJ , HATALSKI RAMAN
Published: January 2021

Good quality bitumen used in the production of bitumen-aggregate mixtures is a binder with high stiffness and elasticity at high operating temperatures occurring in summer and adequate flexibility during exposure to sub-zero temperatures. Currently, one of the best technological solutions to improve the viscoelasticity of bitumen and the resistance to ageing is their modification with various types of additives. The paper presents the results of penetration tests as a function of temperature, softening point (ring and ball method) and strain energy at various temperatures of road bitumen modified with SBS (styrene-butadiene-styrene) copolymer, crumb rubber and simultaneous bitumen modification with SBS copolymer and crumb rubber. The obtained results allowed to assess temperature sensitivity, resistance to changes in selected technical properties of the tested binders as a result of technological ageing process with RTFOT (Roler Thin Film Oven Tester) method and to evaluate changes in their technical properties in relation to the 50/70 base bitumen. Multivariate analysis of variance (MANOVA) was used to analyse the impact of the modification type on the test results of technical properties (significance of the impact of the considered factors on the level of technical properties).
Kepatuhan Diet Pasien Diabetes Melitus Rawat Inap di RSUD dr. Soekarjo Tasikmalaya
Authors: Listianasari Yanita , Nuraeni Irma , Hadiningsih Naning
Published: January 2021

Diabetes melitus merupakan salah satu penyakit metabolik sindrom yang ditandai dengan terjadinya hiperglikemia dan gangguan metabolisme karbohidrat, lemak dan protein yang dihubungkan dengan kekurangan secara absolut atau relatif dari kerja dan atau sekresi insulin. Penelitian ini bertujuan untuk mengetahui kepatuhan diet pada pasien diabetes melitus rawat inap di RSUD Dr. Soekarjo Kota Tasikmalaya. Jenis penelitian yang digunakan observasional dengan pendekatan cross sectional study. Penelitian ini dilaksanakan di RSUD Dr. Soekardjo Kota Tasikmalaya. Sampel penelitian ini adalah 35 pasien rawat inap penderita diabetes melitus yang telah diberikan diet dari rumah sakit dengan pengambilan sampel secara purposive sampling. Penelitian menunjukkan rata-rata sebagian besar responden memiliki persepsi yang positif (54,3%), motivasi diri yang baik (68,6%), kepercayaan diri yang baik (57,1%), dukungan keluarga yang positif (54,3%), dukungan petugas kesehatan yang baik (65,7%). Diperoleh bahwa sebagian besar responden mengonsumsi makanan dengan jenis yang tepat (62,9%), jumlah kalori tidak tepat (94,3%), dan mengonsumsi makanan dari luar rumah sakit (51,4%).
A representação da homossexualidade no discurso espírita de Divaldo Franco
Authors: Pereira Francisco Jomário
Published: January 2021

Este artigo tem como objetivo analisar a representação da homossexualidade na religião espírita brasileira a partir dos discursos de Divaldo Pereira Franco, médium e intelectual que atualmente personifica a religião no país. Para tanto, utilizamos a Análise do Discurso como estratégia teórica e metodológica para analisar os discursos proferidos e registrados em diferentes arquivos. Observamos que as representações construídas são baseadas na perspectiva cristã e reconfiguradas a partir da apropriação do discurso científico, especificamente Carl Gustav Jung, constituindo uma estratégia discursiva, que atua de forma que o autor / doutrina seja (des) responsabilizado pelo dizer punitivo que é construído em torno do sexo, sexualidade e homossexualidade, o que chamamos de pedagogização da (des) responsabilização. Isso leva à manutenção da lógica heterosexista de controle e repressão das sexualidades vistas como anormais e minoritárias.