bluuebunny/crossref_metadata_2025 huggingface dataset:
Conservation agriculture in the southern highlands of Tanzania: learnings from two decades of research for development.
Authors: Shetto Richard , Mkomwa Saidi , Mlengera Ndabhemeye , Mwakimbwala Remmy
Published: January 2022

Since its introduction into the Southern Highlands of Tanzania by researchers 25 years ago, Conservation Agriculture (CA) has been well received, researched and the concept proven to be increasing productivity and incomes, enhancing resilience of livelihoods and contributing to reducing greenhouse gas emissions. CA research, as defined by the three interlined principles, was introduced into the Southern Highlands by the Tanzania Agricultural Research Institute (TARI) Uyole, formerly Agricultural Research Institute (ARI) Uyole around 1995. Research results showed a labour saving of up to 70% in CA compared to conventional tillage, yield increases of 26%-100% and 360% for maize and sunflower, respectively, partly attributed to higher moisture content (18%-24%) in CA systems. CA was also found to be much more effective in mitigating dry spells and increasing productivity in maize production in areas where average annual rainfall is less than 770 mm. Economic analysis of maize production showed that profits in CA were three times more than in conventional tillage production at US$526.9 ha-1 and US$ 176.6 ha-1, respectively. Profits were twice as much for beans under CA at US$917.4 ha-1 compared to US$376.3 ha-1 for conventional practice. Studies confirm that 5% of farmers in the Southern Highlands have adopted CA. Increased uptake requires addressing challenges including resistance to change in mindset, inaccessibility of appropriate mechanization and cover crop seeds, traditions of free-range communal grazing of livestock (which makes it difficult for farmers to retain crop residue in their farms) and shortage of investment capital. A holistic value chain approach is recommended in CA interventions, bringing together various stakeholders including scientists, trainers, extension workers, administrators, policy makers, agro-inputs and machinery dealers, machinery service providers, agro-processors and financial institutions. The innovations adaptation set-up brings service providers closer to farmers for co-innovation. Long-term CA programmes are recommended, with farmers being taken through the complete learning cycle in testing CA technologies under their own farm environments. This should be complemented by entrepreneurial CA machinery hire services provision to increase the availability of farm power to smallholders unlikely to have the capital or skills to buy and manage their own machinery. The proof of application of the CA concept in the Southern Highlands has set the stage for further scaling the adoption of CA through support from national policies and programmes.
Historical review and future opportunities for wider scaling of conservation agriculture in Tunisia.
Authors: M'hamed Hatem Cheikh , Bahri Haithem , Annabi Mohamed , Frija Aymen , Idoudi Zied
Published: January 2022

In Tunisia, rainfed agriculture is facing the major challenges of low and irregular rainfall, as well as natural resources degradation. These are further accentuated by climate change. Changes in technical and management paradigms are needed to boost agricultural productivity. Since the early 1990s in Tunisia, a Conservation Agriculture (CA) system has been proposed as an adapted set of management principles to ensure more efficient and resilient agricultural production systems. In the last 20 years several research and development (R&D) projects have been implemented. Research findings in Tunisia show that the long-term adoption of CA allows increased crop yields and water use efficiency of cereals, enhanced soil biological life and soil organic carbon and reduced energy costs at farm level. Despite promising research results, adoption and up-scaling of CA in Tunisia has been rather modest (currently some 16,000 ha are managed under CA systems). The purpose of this book chapter is to summarize the previous R&D projects dealing with CA in Tunisia. It also aims to provide better insights into the complexity and potential ongoing solutions for integrating crops and livestock into CA systems. Crop-livestock systems dominate a large part of northern and central Tunisia where most of the rainfed field crops are produced.
Moving paradigms - conservation agriculture with alternative agronomics to minimize inputs.
Authors: Goddard Tom , Kassam Amir , Mkomwa Saidi
Published: January 2022

The African Union Malabo Declaration outlines goals to achieve sustainable production practices for economic growth in the agriculture sector by 2025. Conservation Agriculture (CA) practices represent a climate smart and resource friendly sustainable production system, and these need to be adopted and refined. This will be a paradigm shift for academics, experts and farmers who are embedded in the intensive external-input monoculture tillage systems. From our review of literature, recent history has shown that CA systems are successful and profitable while using less external inputs and expending less energy. Energy use can be reduced by 40% and labour needs by 50%-90%. Research has shown that CA farming is superior in terms of enhancing soil functions, biodiversity, beneficial insects, energy consumption, greenhouse gas (GHG) emissions and resilience to extreme climate events. Nitrogen and other essential elemental crop needs can be reduced by 10%-70% through CA systems. African research and farm testing have shown integrated CA cropping systems can control insect and weed pests while providing more diverse economic crops. For the paradigm shift to occur quickly, efficiently and economically, institutions need to lead change. Policy makers need to start strategic changes to research and institutions by initiating support programmes identified by innovative researchers and agricultural leaders that can move the Malabo dial towards the 2025 goals.
Economic and yield comparisons of different crop and crop-pasture production systems.
Authors: Strauss Johann A.
Published: January 2022

Over the past 15 years the adoption rate of Conservation Agriculture (CA) in southern South Africa has increased at a fast rate, although the adoption of the three pillars of CA was to varying degrees. The adoption of CA happened in the absence of any policy support framework directed to CA. The market drove the adaptation rate with a handful of local producers being the first to adopt no-till (NT) strategies. Long-term field experiments demonstrate that the effects of crop rotation include increased yields from the main wheat crop so that two-thirds of the present total wheat production may be achieved with only half the cropped area under the main crop, and gross margins are better - and dramatically better - with integration of cropping and livestock. This chapter presents an overview of the benefits to yield and economic sustainability of including alternative cash and pasture crops into CA farming systems in the winter rainfall region of southern South Africa.
Livestock integration in conservation agriculture.
Authors: Mkomwa Saidi , Kassam Amir , Duiker Sjoerd W. , Zampaligre Nouhoun
Published: January 2022

Grazing livestock have been presented as an unsurmountable obstacle for Conservation Agriculture (CA) in Africa, because they consume organic cover. But grazing livestock can also make positive contributions to CA, while, if properly managed, sufficient organic cover can be left for soil erosion control and soil health improvement. Urine and manure improve soil fertility and soil health, and increase the agronomic efficiency of fertilizer nutrients. Grazing livestock increase options for crop diversity, such as crop rotations with perennial forages, increased use of cover crops and tree-crop associations. Further, as crop yields improve through application of sustainable intensification methods, greater amounts of above-ground residue become available for livestock nutrition, while greater quantities of below- and above-ground plant residues can be left to improve soil health than are currently returned to the soil. At the same time, in areas where extensive systems are still common, greater amounts of crop residue can be left for soil function because alternative feed sources are available. More research and education on proper integration of livestock in CA in the African context, and successful models of pastoralist-crop farmer collaboration are needed, so both livestock and soil needs can be met.
Enhancing climate resilience using stress-tolerant maize in conservation agriculture in southern Africa.
Authors: Setimela Peter , Nyagumbo Isaiah , Mupangwa Walter , Mutenje Munyaradzi
Published: January 2022

Recurrent and widespread droughts in southern Africa (SA) reduce agricultural productivity and increase food insecurity among smallholder farmers. The average growing-season temperatures are expected to increase by 2.5°C. In SA maize is a staple food, accounting for more than 30% of total calories. The crop is mostly grown by smallholder farmers with limited inputs of fertilizers and improved seed. Most of the maize cultivars grown by farmers are susceptible to heat and drought. Multi-stress-tolerant maize germplasm is one of the climate smart agriculture (CSA) components and, when used in combination with others, can sustainably increase production and resilience of agricultural systems. In this paper we review the performance and economic benefits of drought-tolerant maize cultivars under conventional monocropping practice, under conventional intercropping and in Conservation Agriculture (CA) as part of sustainable intensification to ensure food security for smallholder farmers.
Tillage effect on agronomic efficiency of nitrogen under rainfed conditions of Tanzania.
Authors: Rusinamhodzi Leonard , Njeru James , Sariah John E. , Ngatoluwa Rama , Lagwen Phlorentin P.
Published: January 2022

Nitrogen (N) deficiency is a common feature in soils managed by smallholder farmers in Africa. Crop residue retention, in combination with no-till (NT), may be a pathway to improve agronomic use efficiency of applied N for small-scale farmers under the predominant rainfed conditions. This chapter reports on the results of a study carried out over two cropping seasons in the long rains of 2014 and 2015 on two sites: (i) on-farm (Mandela); and (ii) a research station (SARI) in eastern Tanzania. The experiment consisted of two tillage systems, conventional tillage (CT) and Conservation Agriculture (CA), with a minimum of 2.5 t ha-1 crop residue cover maintained in the plots during the experiment. CT consisted of soil inversion through tillage and removal of crop residues. In the on-farm experiment, maize was grown in plots with four rates of N application: 0, 27, 54 and 108 kg N ha-1. In the on-station trial, five rates were used: 0, 20, 40, 60 and 100 kg N ha-1. Maize yield and agronomic efficiency (AE) of N were used to assess and compare the productivity of the tested treatments. The results showed that tillage, soil type and rate of N application influenced crop productivity. In the clay soils, the differences between tillage practices were small. Under CT, AE ranged between 21.6 and 53.9 kg/kg N, and it was 20.4-60.6 kg/kg N under CA. The lowest fertilizer application rate of 27 kg ha-1 often had the largest AE across the soil types and tillage practices. In the on-station trials at SARI, the largest AE of 24.6 kg/kg N was recorded under CA with 40 kg N ha-1. As in the on-farm trials, the highest N application rate on-station did not lead to the largest AE. In the CT, AE ranged between 11.5 and 16.8 kg/kg N compared with a range of 15.1 to 24.6 kg/kg N for the CA treatment. Overall, crop residue retention, in combination with NT, is important to improve soil moisture and use efficiency of applied nutrients. Additionally, the initial soil fertility status is also important in determining the magnitude of short-term crop response to applied nutrients. Innovative pathways are needed to achieve the multiple objectives played by maize crop residues for results reported here to be sustainable. However, efficiency of nutrient use needs to be assessed, together with returns on investments, as small yields may mean high nutrient use efficiency but not necessarily significant increased returns at the farm level.
Effect of conservation agriculture on soil properties and maize grain yield in the semi-arid Laikipia county, Kenya.
Authors: Kuria Peter , Gitari Josiah , Mkomwa Saidi , Waweru Peter
Published: January 2022

Low and unreliable rainfall, along with poor soil health, is a main constraint to maize production in the semi-arid parts of Kenya that account for over 79% of the country's land area. In the vast county of Laikipia, farmers continue to plant maize despite the predominantly low quantities of precipitation. Participatory farmer experimentation with Conservation Agriculture (CA) was undertaken for six consecutive growing seasons between July 2013 and December 2016 to determine the effectiveness of CA as a method of improving soil properties and enhancing maize yields with the limited rainfall quantities received in these parts of Kenya. The main CA practices tested include chisel tine furrow opening (ripping) and live legume (Lablab purpureus) cover crop, as well as maize stover mulches, all implemented under varying inorganic fertilizer rates. The research was done across 12 administrative locations of Laikipia County where soils are mainly Phaeozems and Vertisols with a clay-loam texture. The research design used was researcher-designed and farmer-managed. In each of the 12 trial sites, participatory farmers' assessments and field days were carried out as a way of outreach to the bigger farming communities around the trial sites. The research findings obtained demonstrated that the use of CA impacts positively on soil properties and is a viable practice for enhancing maize yields in these moisture deficit-prone parts of the country. Soil chemical analysis assessment results showed that CA impacted positively on a number of soil mineral components including organic carbon, total nitrogen, phosphorus, potassium, calcium and pH. Midseason chlorophyll content assessment of the maize crop showed that there was good response to fertilizer application, as well as to mulching with crop residues for soil cover. Maize grain yield data also showed that the use of a CA package comprising chisel tine ripping combined with mulching by plant residues and use of mineral fertilizer resulted in a two- to threefold increase in grain yields above the farmer practice control. Mean maize grain yield in farmer practice plots was 1067 kg ha-1 compared with the CA-treated plot with mineral fertilization that yielded 2192 kg ha-1.
What drives small-scale farmers to adopt conservation agriculture practices in Tanzania?
Authors: Sariah John E. , Mmbando Frank
Published: January 2022

Conservation Agriculture (CA)-based Sustainable Intensification (CASI) practices in this study comprised minimum soil disturbance, permanent soil cover, intercropping of maize and legumes, and use of improved crop genotypes and fertilizers, and were tested on-farm in different agroecologies in northern and eastern Tanzania. The results for six consecutive years of study indicate increased adoption of CASI practices compared to the baseline year (2010). The major impacts of these practices were reduced production costs, labour savings and overall increased crop and land productivity. The average area allocated to improved maize-legume (ML) intercrop rose during the project period by 5.28 ha per household, of which 15% was under complete CASI practices. Adoption trends show that, on average, 6.5% of adopters across the study and spillover communities started adoption in the 2nd year and about 14% of farmers adopted the practices over the next 3-5 years. Demographic and human capital (family size, education, age and farming experience), on-farm CASI demonstrations, farmer to farmer exchange visits, social capital (farmers' group or a cooperative), access to input and output markets (improved seeds, herbicides, fertilizers, insecticides and equipment) and food security were found to have positive and significant effects on adoption of a range of CASI practices. These results suggest continued and long-term efforts in investments in demonstrations, institutionalizing CASI practices in NARS, and good links to input and output markets, including appropriate machinery, are necessary to achieve sustained adoption.
Impact of conservation agriculture on soil health: lessons from the university of fort hare trial.
Authors: Muzangwa Lindah , Gura Isaac , Mcinga Sixolise , Mnkeni Pearson Nyari , Chiduza Cornelius
Published: January 2022

Conservation Agriculture (CA) promotes soil health, but issues to do with soil health are poorly researched in the Eastern Cape, South Africa. This study reports on findings from a field trial done on the effects of tillage, crop rotations composed of maize (Zea mays L.), wheat (Triticum aestivum L.) and soybean (Glycine max L.) and residue management on a number of soil health parameters such as carbon (C)-sequestration, CO2 fluxes, enzyme activities, earthworm biomass and the Soil Management Assessment Framework soil quality index (SMAF-SQI). The field trial was done in a semi-arid region of the Eastern Cape Province, South Africa, over five cropping seasons (2012-2015). It was laid out as a split-split plot with tillage [conventional tillage (CT) and no-till (NT)] as main plot treatment. Sub-treatments were crop rotations: maize-fallow-maize (MFM), maize-fallow-soybean (MFS); maize-wheat-maize (MWM) and maize-wheat-soybean (MWS). Residue management: removal (R-) and retention (R+) were in the sub-sub-plots. Particulate organic matter (POM), soil organic carbon (SOC), microbial biomass carbon (MBC) and enzyme activities were significantly (p < 0.05) improved by residue retention and legume rotation compared to residue removal and cereal-only rotations. Also, carbon dioxide (CO2) fluxes under CT were higher compared to NT. The calculated soil quality index (SQI) was greatly improved by NT and residue retention. MWM and MWS rotations, in conjunction with residue retention under NT, offered the greatest potential for building soil health. Residue retention and inclusion of soybean in crop rotations are recommended for improving soil health under CA systems in the semi-arid regions of South Africa.
Strengthening conservation agriculture education in Africa.
Authors: Clark Cary , Kassam Amir , Mkomwa Saidi , Kuria Peter , Mutai Weldone
Published: January 2022

This chapter brings together recent developments and ongoing efforts in Conservation Agriculture (CA) education in Africa. It covers areas related to online education and training including CA Massive Open Online Courses (MOOCs), CA-based education and training capacity, CA curriculum development and CA quality assurance. An overview of emerging opportunities in CA education and training are elaborated in general, as well as through specific efforts of institutions such as the African Conservation Tillage Network. CA-based land use transformation occurring in Africa, and the growth of related supporting activities in public and private sectors, represent an important area of opportunity for education and training. It also offers opportunity for youth to develop their vocational and professional careers in the food and agriculture sector.
Lessons learnt from concern worldwide's conservation agriculture interventions in Malawi and Zambia, 2010-2018.
Authors: Wahl Carl
Published: January 2022

Conservation Agriculture (CA) is a gateway technology intended to build both the productivity and resilience of smallholder farmers. Since 2010, the Ireland-based NGO Concern Worldwide has been promoting CA with extremely poor farmers in Malawi and Zambia. In the context of the specific regions within both countries, similar conditions of limited labour capacity, low financial capacity, poor soil health and constrained agriculture extension services were the primary barriers to the poorest farmers. Initial CA projects utilized broad, standardized approaches to CA with subsidized inputs that led to yield increases, but saw limited non-subsidized adoption. As a result, Concern has adapted its approaches to CA to better accommodate and embrace innovation by lead farmers, understanding different adoption strategies for follower farmers and working to improve input supply systems to meet farmers' needs. However, major constraints to adoption remain for the poorest and, going forward, CA projects will need to incorporate robust strategies for household financial stability such as the graduation model; fostering greater innovation by lead farmers within CA principles to meet local contexts; and integrating seed selection and saving for non-commercialized food crops to spur large-scale adoption of CA by the poorest farmers.
Development of adaptive training materials for conservation agriculture promotion in Africa.
Authors: Miller Neil , Nyathi Putso , Twilingiyumukiza Jean
Published: January 2022

In order for Conservation Agriculture (CA) to reach and impact small-scale farmers in Sub-Saharan Africa (SSA), CA technologies need to be adapted to suit the diversity of agroecological zones and cultures present on the continent. Training materials for CA promotion need to be similarly customizable to help extension staff and farmers develop their own, context-appropriate solutions from among the many possible CA approaches. From 2015 through 2018, a diverse set of farmer-level training materials for CA and complementary technologies was developed and field-tested by Canadian Foodgrains Bank partners. Together with a participatory, adaptive training methodology, these materials have enhanced the effectiveness of CA promotion, and they have been made available for copyright-free download in English, French, Kiswahili, Portuguese and Amharic (http://caguide.act-africa.org/, accessed 6 August 2021). This paper describes the process of developing these materials as well as challenges and constraints to their utilization.
Sustainable agricultural mechanization and commercialization for widespread adoption of conservation agriculture systems in Africa.
Authors: Kienzle Josef , Sims Brian , Mutai Weldone
Published: January 2022

To confront the situations of climate crisis, natural resource degradation and rising populations, farmers need access to modern sustainable agricultural technologies, especially Conservation Agriculture (CA) and sustainable agricultural mechanization (SAM). Without such access, the UN's SDGs will not be met in their entirety. The implications of mechanizing CA are discussed for both smallholder and larger-scale farmers. Constraints, issues and options are reviewed and the need for commercial, private sector, CA mechanization service provision for smallholders is identified. The Framework for Sustainable Agricultural Mechanization for Africa (SAMA) is a key pillar for achieving Aspiration 1 (a prosperous Africa based on inclusive growth and sustainable development) of the African Union's (AU) Agenda 2063; and SDG 2 (ending hunger and achieving food security). The move towards commercialization of smallholder agriculture in Africa is seen as an inevitable reality in the medium term. It is also a necessary prerequisite for the adoption of SAM, which is being actively promoted in Africa, both at the level of the AU and by national governments, research centres, non-governmental organizations (NGOs) and private-sector agricultural machinery companies. The policy dimensions of promoting SAM are discussed from the public and private-sector perspectives. A forward look identifies novel business models for sustainable mechanization services, an increasing application of information technology (IT) and the (longer term) potential for drones and robotics. The conclusion is that CA and SAM are essential ways forward to answer Africa's needs for sustainable food production while engaging young entrepreneurs in the provision of mechanization services using IT, digital tools and precision equipment.
Centres of excellence in conservation agriculture: developing African institutions for sustainable agricultural development.
Authors: Mkomwa Saidi , Lugandu Simon , Macharia Ngari , Bot Alexandra , Mutai Weldone
Published: January 2022

Conservation Agriculture (CA) is an important component in addressing food insecurity, biodiversity degradation and water scarcity challenges. Its adoption in Africa has lagged behind other continents. One major area of need to enable the acceleration of the adoption of CA in Africa relates to building the necessary cross-sectoral institutional and human capacity across the education-research-extension-enterprise axis along the value chain. This study was conducted in order to contribute to the discussions about the need to create sustainable institutions: specifically, Conservation Agriculture Centres of Excellence (CA-CoEs) in Africa. The CA-CoEs model includes a stakeholder team, a shared facility or an entity that provides leadership, best practices, research, support and/or training in CA, with linkages to service providers along the value chain. This literature-based research involved systematic identification, collection, analysis and documentation of data to identify and address the unique roles these CA-CoEs play in the promotion and adoption of CA and their level of performance. It employed a CA quality assurance self-assessment tool to measure the performance of the CA-CoEs against predetermined performance descriptors. Although the CA-CoEs are facilitating and catalysing adoption of CA, their capacity in providing the CA-related programmes, training and research is not optimal. CA-CoE quality assurance of services can be helpful in identification and design of measures for addressing the challenges faced. To be impactful, CA-CoEs need well-coordinated, participatory and demand-driven CA-based agricultural practices, information services and knowledge for farmers and other stakeholders such as non-governmental organizations (NGOs), CA service providers and CA equipment manufacturers.
The future: towards agenda 2063.
Authors: Bwalya Martin , Mkomwa Saidi , Shula Reynolds , Lugandu Simon , Kassam Amir
Published: January 2022

This chapter discusses the foreseeable future of agriculture in Africa, which has a major contribution to make in terms of food security, and also in terms of economic, social and environmental development. The changing climate in Africa already calls for the adoption of the best alternative agricultural production strategy that can deliver both productivity and ecosystem services. This chapter also highlights important findings from the book such as the new expertise and experience in Conservation Agriculture (CA) that has been gained, especially during the last decade. Research, training, farmer innovation and the increasing agricultural investments in institution building mean that CA now holds greater promise of serving as a sustainable pillar in the implementation of Agenda 2063. Also included in this chapter is a transcription of the speech of the Director General of the Department of Agriculture, Forestry and Fisheries (DAFF), Mr Mzamo Michael Mlenganaduring during the official opening of the Congress, wherein he called for a greater contribution by CA and the multi-stakeholder CA community of practice towards Agenda 2063.
Evaluation of phenotype-driven gene prioritization methods for Mendelian diseases
Authors: Yuan Xiao , Wang Jing , Dai Bing , Sun Yanfang , Zhang Keke , Chen Fangfang , Peng Qian , Huang Yixuan , Zhang Xinlei , Chen Junru , Xu Xilin , Chuan Jun , Mu Wenbo , Li Huiyuan , Fang Ping , Gong Qiang , Zhang Peng
Published: January 2022

It’s challenging work to identify disease-causing genes from the next-generation sequencing (NGS) data of patients with Mendelian disorders. To improve this situation, researchers have developed many phenotype-driven gene prioritization methods using a patient’s genotype and phenotype information, or phenotype information only as input to rank the candidate’s pathogenic genes. Evaluations of these ranking methods provide practitioners with convenience for choosing an appropriate tool for their workflows, but retrospective benchmarks are underpowered to provide statistically significant results in their attempt to differentiate. In this research, the performance of ten recognized causal-gene prioritization methods was benchmarked using 305 cases from the Deciphering Developmental Disorders (DDD) project and 209 in-house cases via a relatively unbiased methodology. The evaluation results show that methods using Human Phenotype Ontology (HPO) terms and Variant Call Format (VCF) files as input achieved better overall performance than those using phenotypic data alone. Besides, LIRICAL and AMELIE, two of the best methods in our benchmark experiments, complement each other in cases with the causal genes ranked highly, suggesting a possible integrative approach to further enhance the diagnostic efficiency. Our benchmarking provides valuable reference information to the computer-assisted rapid diagnosis in Mendelian diseases and sheds some light on the potential direction of future improvement on disease-causing gene prioritization methods.
Lower Prevalence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Among People Experiencing Homelessness Tested in Outdoor Encampments Compared With Overnight Shelters: Denver, Colorado, June–July 2020
Authors: Rowan Sarah E , McCormick David W , Wendel Karen A , Scott Tracy , Chavez-van de Hey Jesse , Wilcox Kay , Stella Sarah A , Kamis Kevin , Burman William J , Marx Grace E
Published: January 2022

Background

A better understanding of the risk for coronavirus disease 2019 (COVID-19) that people experiencing homelessness (PEH) face in congregate shelters versus unsheltered encampments is critical for an effective pandemic response.

Methods

We analyzed factors associated with current and past severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among PEH in day and overnight shelters and encampments in Denver, Colorado, during June 2–July 28, 2020, and constructed multivariable logistic regression models to examine risk factors for SARS-CoV-2 RNA and seropositivity with age, race/ethnicity, testing location, testing month, and symptom status as predictor variables.

Results

A total of 823 participants were tested for SARS-CoV-2 RNA, and 276 individuals were tested for SARS-CoV-2 antibodies. A greater percentage of PEH at overnight shelters tested positive for SARS-CoV-2 RNA (8.6% vs 2.5%, P < .01) and antibodies (21.5% vs 8.7%, P = .03) compared with encampments. In regression models, testing at an overnight shelter compared with testing at encampments (odds ratio [OR] = 3.03, 95% confidence interval [CI]: 1.16–9.02) had increased odds of a positive SARS-CoV-2 RNA result. Age >60 years compared with age <40 years (OR = 5.92; 95% CI: 1.83–20.3), Hispanic ethnicity (OR = 3.43; 95% CI: 1.36–8.95), and non-Hispanic Black race compared with non-Hispanic White race (OR = 3.07; 95% CI: 1.16–8.26), and testing at an overnight shelter compared to testing at encampments (OR = 2.45; 95% CI: 1.04–6.17) had increased odds of a positive antibody result.

Conclusions

Our findings support the need for continuing assessment of mitigation strategies in shelters, increasing access to individual rooms and linkage to housing options for PEH, and supporting people to remain in encampments when these options are not available.
Fate of patients weaned from post-cardiotomy extracorporeal life support
Authors: Schaefer Anne-Kristin , Riebandt Julia , Bernardi Martin H , Distelmaier Klaus , Goliasch Georg , Zimpfer Daniel , Laufer Günther , Wiedemann Dominik
Published: January 2022

OBJECTIVES

Although post-cardiotomy extracorporeal life support (PC-ECLS) is a potentially life-saving resource for patients with cardiopulmonary failure after cardiac surgery, adverse outcomes have been reported even in successfully weaned patients. The goal of this study was to assess outcome in patients weaned from PC-ECLS.

METHODS

Of 573 consecutive patients who received PC-ECLS at a single centre between 2000 and 2019, 478 patients were included in a retrospective analysis. Successful weaning was defined as survival >24 h after extracorporeal life support (ECLS) explantation. Mortality of patients on ECLS, as well as in-hospital mortality of weaned patients, was assessed. A binary logistic regression model with backward elimination was used to identify predictors for in-hospital mortality after successful ECLS explantation.

RESULTS

Of 478 included patients, 120 patients (25.1%) died on ECLS or within 24 h after ECLS explantation. A total of 358 patients were successfully separated from ECLS and survived for >24 h (n = 352 weaned, n = 3 transitioned to durable left ventricular assist device and n = 3 transitioned to a heart transplant). A total of 35.5% of patients who were successfully weaned from ECLS did not survive until hospital discharge. In-hospital deaths of the whole cohort were 51.7% (247/478 patients). For patients who survived to discharge (231/478 patients, 48.3%), survival was 87% after 1 year and 68.9% after 5 years.

CONCLUSIONS

In-hospital mortality of patients requiring PC-ECLS is high even in case of successful weaning. Longer ECLS duration, older age, female gender and low preoperative glomerular filtration rate were risk factors for in-hospital mortality after ECLS weaning. Survival of patients discharged after PC-ECLS was encouraging.
Light to moderate coffee consumption is associated with lower risk of death: a UK Biobank study
Authors: Simon Judit , Fung Kenneth , Raisi-Estabragh Zahra , Aung Nay , Khanji Mohammed Y , Kolossváry Márton , Merkely Béla , Munroe Patricia B , Harvey Nicholas C , Piechnik Stefan K , Neubauer Stefan , Petersen Steffen E , Maurovich-Horvat Pál
Published: January 2022

Aims

To study the association of daily coffee consumption with all-cause and cardiovascular (CV) mortality and major CV outcomes. In a subgroup of participants who underwent cardiovascular magnetic resonance (CMR) imaging, we evaluated the association between regular coffee intake and cardiac structure and function.

Methods and results

UK Biobank participants without clinically manifested heart disease at the time of recruitment were included. Regular coffee intake was categorized into three groups: zero, light-to-moderate (0.5–3 cups/day), and high (>3 cups/day). In the multivariate analysis, we adjusted for the main CV risk factors. We included 468 629 individuals (56.2 ± 8.1 years, 44.2% male), of whom 22.1% did not consume coffee regularly, 58.4% had 0.5–3 cups per day, and 19.5% had >3 cups per day. Compared to non-coffee drinkers, light-to-moderate (0.5–3 cups per day) coffee drinking was associated with lower risk of all-cause mortality [multivariate hazard ratio (HR) = 0.88, 95% confidence interval (CI): 0.83–0.92; P < 0.001] and CV mortality (multivariate HR = 0.83, 95% CI: 0.74–0.94; P = 0.006), and incident stroke (multivariate HR = 0.79, 95% CI: 0.63–0.99 P = 0.037) after a median follow-up of 11 years. CMR data were available in 30 650 participants. Both light-to-moderate and high coffee consuming categories were associated with dose-dependent increased left and right ventricular end-diastolic, end-systolic and stroke volumes, and greater left ventricular mass.

Conclusion

Coffee consumption of up to three cups per day was associated with favourable CV outcomes. Regular coffee consumption was also associated with a likely healthy pattern of CMR metrics in keeping with the reverse of age-related cardiac alterations.
The impacts of long-term care insurance on health care utilization and expenditure: evidence from China
Authors: Chen He , Ning Jing
Published: January 2022

Long-term care insurance (LTCI) is one of the important institutional responses to the growing care needs of the ageing population. Although previous studies have evaluated the impacts of LTCI on health care utilization and expenditure in developed countries, whether such impacts exist in developing countries is unknown. The Chinese government has initiated policy experimentation on LTCI to cope with the growing and unmet need for aged care. Employing a quasi-experiment design, this study aims to examine the policy treatment effect of LTCI on health care utilization and out-of-pocket health expenditure (OOP) in China. The Propensity Score Matching with difference-in-difference approach was used to analyse the data obtained from four waves of China Health and Retirement Longitudinal Study. Our findings indicate that, in the aspect of health care utilization, the introduction of LTCI significantly reduced the number of outpatient visits by 0.322 times (P < 0.05), the number of hospitalizations by 0.158 times (P < 0.01) and the length of inpatient stay during last year by 1.441 days (P < 0.01). In the aspect of OOP, we found that LTCI significantly reduced the inpatient OOP during last year by 533.47 yuan (P < 0.01), but it did not exhibit an impact on the outpatient OOP during last year. LTCI also had a significantly negative impact on the total OOP by 512.56 yuan. These results are stable in the robustness tests. Considering the evident policy treatment effect of LTCI on health care utilization and OOP, the expansion of LTCI could help reduce the needs for health care services and contain the increases in OOP in China.
Predicting Risk of Surgery in Patients With Small Bowel Crohn’s Disease Strictures Using Computed Tomography and Magnetic Resonance Enterography
Authors: Inoue Akitoshi , Bartlett David J , Shahraki Narges , Sheedy Shannon P , Heiken Jay P , Voss Benjamin A , Fidler Jeff L , Tootooni Mohammad S , Sir Mustafa Y , Pasupathy Kalyan , Baker Mark E , Rieder Florian , Lightner Amy L , Deepak Parakkal , Bruining David H , Fletcher Joel G
Published: January 2022

Background

We aimed to determine if patient symptoms and computed tomography enterography (CTE) and magnetic resonance enterography (MRE) imaging findings can be used to predict near-term risk of surgery in patients with small bowel Crohn’s disease (CD).

Methods

CD patients with small bowel strictures undergoing serial CTE or MRE were retrospectively identified. Strictures were defined by luminal narrowing, bowel wall thickening, and unequivocal proximal small bowel dilation. Harvey-Bradshaw index (HBI) was recorded. Stricture observations and measurements were performed on baseline CTE or MRE and compared to with prior and subsequent scans. Patients were divided into those who underwent surgery within 2 years and those who did not. LASSO (least absolute shrinkage and selection operator) regression models were trained and validated using 5-fold cross-validation.

Results

Eighty-five patients (43.7 ± 15.3 years of age at baseline scan, majority male [57.6%]) had 137 small bowel strictures. Surgery was performed in 26 patients within 2 years from baseline CTE or MRE. In univariate analysis of patients with prior exams, development of stricture on the baseline exam was associated with near-term surgery (P = .006). A mathematical model using baseline features predicting surgery within 2 years included an HBI of 5 to 7 (odds ratio [OR], 1.7 × 105; P = .057), an HBI of 8 to 16 (OR, 3.1 × 105; P = .054), anastomotic stricture (OR, 0.002; P = .091), bowel wall thickness (OR, 4.7; P = .064), penetrating behavior (OR, 3.1 × 103; P = .096), and newly developed stricture (OR: 7.2 × 107; P = .062). This model demonstrated sensitivity of 67% and specificity of 73% (area under the curve, 0.62).

Conclusions

CTE or MRE imaging findings in combination with HBI can potentially predict which patients will require surgery within 2 years.
Universality of Poisson Limits for Moduli of Roots of Kac Polynomials
Authors: Cook Nicholas A , Nguyen Hoi H , Yakir Oren , Zeitouni Ofer
Published: January 2022

We give a new proof of a recent resolution [18] by Michelen and Sahasrabudhe of a conjecture of Shepp and Vanderbei [19] that the moduli of roots of Gaussian Kac polynomials of degree $n$, centered at $1$ and rescaled by $n^2$, should form a Poisson point process. We use this new approach to verify a conjecture from [18] that the Poisson statistics are in fact universal.
The Male Hindwing Costal Roll in Cochylina (Lepidoptera: Tortricidae): Morphological Variation, Phylogenetic Distribution, and Relationship to Host Utilization
Authors: Pérez Santa-Rita José V , Brown John W , Baixeras Joaquín
Published: January 2022

This is the first morphological study of the male hindwing costal roll (CR), a scent organ of tortricid moths of the subtribe Cochylina (Lepidoptera, Tortricidae). This composite organ varies from a simple membranous roll of the hindwing costa to a complex roll that incorporates a hairpencil and two types of microscales. All the components show taxon-dependent traits. Both optical and electron microscopy are used to elucidate the structure. The costal roll is associated primarily with the Aethes Billberg, Saphenista Walsingham, Phalonidia Le Marchand, and Cochylis Treitschke groups of genera. The general notions that wing male scent organs are phylogenetically labile and that they may have arisen among closely related species as a consequence of habitat sharing are explored using network analysis and phylogenetic signal. Taxa with a costal roll certainly support a more complex area of the food web, however, the character shows a strong phylogenetic signal and is not the result of a sporadic evolution.
Population Dynamics of Eriophyid Mites and Evaluation of Different Management Practices on Timothy Grass
Authors: Dively Galen P , Hartman Margaret E , Ochoa Ronald
Published: January 2022

Several species of eriophyid mites are important economic pests of timothy grass in the Mid-Atlantic United States. Feeding causes stunting, curling, and brown discoloration of leaves, and yield losses ranging up to 50%. Carbaryl is the only approved chemical control for these mites. We investigated the population dynamics of field infestations, host plant resistance, and several cultural control measures to develop a more sustainable management strategy. Seasonal phenology and overall abundance differed among timothy fields and between years, with mean peak densities ranging up to 731 eggs and 1,163 mites per 2.5 cm of leaf blade. Population differences were related to the age of the field, the prevailing temperatures, and snow cover during the fall and winter months. All varieties of timothy tested were susceptible, whereas several other forage grasses were significantly resistant to eriophyid mites as possible alternatives for replacing timothy. Fall harvesting reduced the buildup of mites during the winter but populations eventually rebounded and still reached economic densities by April. Burn-down herbicide, prescribed burning, and urea-based fertilizer treatments prior to green-up in the early spring had variable effects and may help to prevent economic losses; however, several concerns about the benefit/costs and practicality of these practices are discussed.
Clinical issues of surgery for uterine endometrial cancer in Japan
Authors: Nagai Tomoyuki , Shimada Muneaki , Tokunaga Hideki , Ishikawa Mitsuya , Yaegashi Nobuo
Published: January 2022

Objective

The mainstay of treatment for uterine endometrial cancer is surgery, and recurrent-risk cases require multidisciplinary treatment, including surgery, chemotherapy and radiation therapy.

Methods

The standard surgery for uterine endometrial cancer is hysterectomy and bilateral salpingooophorectomy, with additional retroperitoneal lymph node dissection and omentectomy, depending on the case. The appropriate treatment is determined based on the risk classification, such as the depth of invasion into the myometrium, diagnosis of histological type and grade, and risk assessment of lymph node metastasis.

Results

Recently, minimally invasive surgery has been widely used not only in low-risk patients but also in intermediate- and high-risk patients. In low-risk patients, the possibility of ovarian preservation is discussed from a healthcare perspective for young women. Determining the need for retroperitoneal lymph node dissection based on sentinel lymph node evaluation may contribute in minimizing the incidence of post-operative lymphedema while ensuring accurate diagnosis of lymph node metastasis. Recently, many studies using sentinel lymph nodes have been reported for patients with uterine endometrial cancer, and the feasibility of sentinel lymph node mapping surgery has been proven. Unfortunately, sentinel lymph node biopsy and sentinel lymph node mapping surgery have not been widely adopted in surgery for uterine cancer in Japan. In addition, the search for biomarkers, such as RNA sequencing using The Cancer Genome Atlas, metabolic profile and lipidomic profile for early detection and prognostic evaluation, has been actively pursued.

Conclusions

Gynecologic oncologists expect to be able to provide uterine endometrial cancer patients with appropriate treatment that preserves their quality of life without compromising oncologic outcomes in the near future.
Surgical administration of multiple glomus tumors in uncommon anatomic regions in a 17-year-old female. A rare case report
Authors: Mariolis-Sapsakos Theodoros , Zarokosta Maria , Lazaridis Nikolaos , Mourtzoukou Despoina , Vlachodimitropoulos Dimitrios , Patrinos Antonios , Foutsitzi Aikaterini , Paraskevas George
Published: January 2022

Glomus tumor (GT) constitutes a rare, benign, soft-tissue tumor emerging from neuro-myo-arterial glomus bodies. Due to its rarity, and absence of typical symptoms, GT is usually misdiagnosed, with a potential risk of rupture and infection, or even malignant transformation. The present manuscript reports a rare case of a 17-year-old young woman with multiple GTs in her lower back, breach and left thigh that was surgically treated. The manuscript aims to highlight the importance of prompt diagnosis and surgical treatment of this peculiar tumor in young patients and raise surgeons’ awareness.
Genome Resequencing Reveals Rapid, Repeated Evolution in the Colorado Potato Beetle
Authors: Pélissié Benjamin , Chen Yolanda H , Cohen Zachary P , Crossley Michael S , Hawthorne David J , Izzo Victor , Schoville Sean D
Published: January 2022

Insecticide resistance and rapid pest evolution threatens food security and the development of sustainable agricultural practices, yet the evolutionary mechanisms that allow pests to rapidly adapt to control tactics remains unclear. Here, we examine how a global super-pest, the Colorado potato beetle (CPB), Leptinotarsa decemlineata, rapidly evolves resistance to insecticides. Using whole-genome resequencing and transcriptomic data focused on its ancestral and pest range in North America, we assess evidence for three, nonmutually exclusive models of rapid evolution: pervasive selection on novel mutations, rapid regulatory evolution, and repeated selection on standing genetic variation. Population genomic analysis demonstrates that CPB is geographically structured, even among recently established pest populations. Pest populations exhibit similar levels of nucleotide diversity, relative to nonpest populations, and show evidence of recent expansion. Genome scans provide clear signatures of repeated adaptation across CPB populations, with especially strong evidence of selection on insecticide resistance genes in different populations. Analyses of gene expression show that constitutive upregulation of candidate insecticide resistance genes drives distinctive population patterns. CPB evolves insecticide resistance repeatedly across agricultural regions, leveraging similar genetic pathways but different genes, demonstrating a polygenic trait architecture for insecticide resistance that can evolve from standing genetic variation. Despite expectations, we do not find support for strong selection on novel mutations, or rapid evolution from selection on regulatory genes. These results suggest that integrated pest management practices must mitigate the evolution of polygenic resistance phenotypes among local pest populations, in order to maintain the efficacy and sustainability of novel control techniques.