bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Potato Virus Y Isolates and Assessment of Nanopore Sequencing to Detect and Genotype Potato Viruses
Authors: Della Bartola Michele , Byrne Stephen , Mullins Ewen
Published: April 2020

Potato virus Y (PVY) is the most economically important virus infecting cultivated potato (Solanum tuberosum L.). Accurate diagnosis is crucial to regulate the trade of tubers and for the sanitary selection of plant material for propagation. However, high genetic diversity of PVY represents a challenge for the detection and classification of isolates. Here, the diversity of Irish PVY isolates from a germplasm collection and commercial sites was investigated using conventional molecular and serological techniques. Recombinant PVY isolates were prevalent, with PVYNTNa being the predominant genotype. In addition, we evaluated Nanopore sequencing to detect and reconstruct the whole genome sequence of four viruses (PVY, PVX, PVS, PLRV) and five PVY genotypes in a subset of eight potato plants. De novo assembly of Nanopore sequencing reads produced single contigs covering greater than 90% of the viral genome and sharing greater than 99.5% identity to the consensus sequences obtained with Illumina sequencing. Interestingly, single near full genome contigs were obtained for different isolates of PVY co-infecting the same plant. Mapping reads to available reference viral genomes enabled us to generate near complete genome sequences sharing greater than 99.90% identity to the Illumina-derived consensus. This is the first report describing the use of Oxford Nanopore’s MinION to detect and genotype potato viruses. We reconstructed the genome of PVY and other RNA viruses; indicating the technologies potential for virus detection in potato production systems, and for the study of genetic diversity of highly heterogeneous viruses such as PVY.
Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice
Authors: Li Yaohui , Li Ruihua , Wang Meirong , Liu Yujiao , Yin Ying , Zai Xiaodong , Song Xiaohong , Chen Yi , Xu Junjie , Chen Wei
Published: April 2020

The genus Henipavirus (HNVs) includes two fatal viruses, namely Nipah virus (NiV) and Hendra virus (HeV). Since 1994, NiV and HeV have been endemic to the Asia–Pacific region and responsible for more than 600 cases of infections. Two emerging HNVs, Ghana virus (GhV) and Mojiang virus (MojV), are speculated to be associated with unrecognized human diseases in Africa and China, respectively. Despite many efforts to develop vaccines against henipaviral diseases, there is presently no licensed human vaccine. As HNVs are highly pathogenic and diverse, it is necessary to develop universal vaccines to prevent future outbreaks. The attachment enveloped glycoprotein (G protein) of HNVs mediates HNV attachment to the host cell’s surface receptors. G proteins have been used as a protective antigen in many vaccine candidates for HNVs. We performed quantitative studies on the antibody responses elicited by the G proteins of NiV, HeV, GhV, and MojV. We found that the G proteins of NiV and HeV elicited only a limited cross-reactive antibody response. Further, there was no cross-protection between MojV, GhV, and highly pathogenic HNVs. We then constructed a bivalent vaccine where the G proteins of NiV and HeV were fused with the human IgG1 Fc domain. The immunogenicity of the bivalent vaccine was compared with that of monovalent vaccines. Our results revealed that the Fc-based bivalent vaccine elicited a potent antibody response against both NiV and HeV. We also constructed a tetravalent Fc heterodimer fusion protein that contains the G protein domains of four HNVs. Immunization with the tetravalent vaccine elicited broad antibody responses against NiV, HeV, GhV, and MojV in mice, indicating compatibility among the four antigens in the Fc-fusion protein. These data suggest that our novel bivalent and tetravalent Fc-fusion proteins may be efficient candidates to prevent HNV infection.
Multi-Agent Simulation of Individuals’ Escape in the Urban Rainstorm Context Based on Dynamic Recognition-Primed Decision Model
Authors: Yang Qing , Sun Xu , Liu Xingxing , Wang Jinmei
Published: April 2020

The urban rainstorm can evolve into a serious emergency, generally characterized by high complexity, uncertainty, and time pressure. It is often difficult for individuals to find the optimal response strategy due to limited information and time constraints. Therefore, the classical decision-making method based on the “infinite rationality” assumption is sometimes challenging to reflect the reality. Based on the recognition-primed decision (RPD) model, a dynamic RPD (D-RPD) model is proposed in this paper. The D-RPD model assumes that decision-makers can gain experience in the escaping process, and the risk perception of rainstorm disasters can be regarded as a Markov process. The experience of recent attempts would contribute more in decision-making. We design the agent according to the D-RPD model, and employ a multi-agent system (MAS) to simulate individuals’ decisions in the context of a rainstorm. Our results show that experience helps individuals to perform better when they escape in the rainstorm. Recency acts as a one of the key elements in escaping decision making. We also find that filling the information gap between individuals and real-time disaster would help individuals to perform well, especially when individuals tend to avoid extreme decisions.
Machine Learning Approaches for Predicting Health Risk of Cyanobacterial Blooms in Northern European Lakes
Authors: Mellios Nikolaos , Moe S. , Laspidou Chrysi
Published: April 2020

Cyanobacterial blooms are considered a major threat to global water security with documented impacts on lake ecosystems and public health. Given that cyanobacteria possess highly adaptive traits that favor them to prevail under different and often complicated stressor regimes, predicting their abundance is challenging. A dataset from 822 Northern European lakes is used to determine which variables better explain the variation of cyanobacteria biomass (CBB) by means of stepwise multiple linear regression. Chlorophyll-a (Chl-a) and total nitrogen (TN) provided the best modelling structure for the entire dataset, while for subsets of shallow and deep lakes, Chl-a, mean depth, TN and TN/TP explained part of the variance in CBB. Path analysis was performed and corroborated these findings. Finally, CBB was translated to a categorical variable according to risk levels for human health associated with the use of lakes for recreational activities. Several machine learning methods, namely Decision Tree, K-Nearest Neighbors, Support-vector Machine and Random Forest, were applied showing a remarkable ability to predict the risk, while Random Forest parameters were tuned and optimized, achieving a 95.81% accuracy, exceeding the performance of all other machine learning methods tested. A confusion matrix analysis is performed for all machine learning methods, identifying the potential of each method to correctly predict CBB risk levels and assessing the extent of false alarms; random forest clearly outperforms the other methods with very promising results.
Nitrogen Surplus—A Unified Indicator for Water Pollution in Europe?
Authors: Klages Susanne , Heidecke Claudia , Osterburg Bernhard , Bailey John , Calciu Irina , Casey Clare , Dalgaard Tommy , Frick Hanna , Glavan Matjaž , D’Haene Karoline , Hofman Georges , Leitão Inês , Surdyk Nicolas , Verloop Koos , Velthof Gerard
Published: April 2020

Pollution of ground-and surface waters with nitrates from agricultural sources poses a risk to drinking water quality and has negative impacts on the environment. At the national scale, the gross nitrogen budget (GNB) is accepted as an indicator of pollution caused by nitrates. There is, however, little common EU-wide knowledge on the budget application and its comparability at the farm level for the detection of ground-and surface water pollution caused by nitrates and the monitoring of mitigation measures. Therefore, a survey was carried out among experts of various European countries in order to assess the practice and application of fertilization planning and nitrogen budgeting at the farm level and the differences between countries within Europe. While fertilization planning is practiced in all of the fourteen countries analyzed in this paper, according to current legislation, nitrogen budgets have to be calculated only in Switzerland, Germany and Romania. The survey revealed that methods of fertilization planning and nitrogen budgeting at the farm level are not unified throughout Europe. In most of the cases where budgets are used regularly (Germany, Romania, Switzerland), standard values for the chemical composition of feed, organic fertilizers, animal and plant products are used. The example of the Dutch Annual Nutrient Cycling Assessment (ANCA) tool (and partly of the Suisse Balance) shows that it is only by using farm-specific “real” data that budgeting can be successfully applied to optimize nutrient flows and increase N efficiencies at the farm level. However, this approach is more elaborate and requires centralized data processing under consideration of data protection concerns. This paper concludes that there is no unified indicator for nutrient management and water quality at the farm level. A comparison of regionally calculated nitrogen budgets across European countries needs to be interpreted carefully, as methods as well as data and emission factors vary across countries. For the implementation of EU nitrogen-related policies—notably, the Nitrates Directive—nutrient budgeting is currently ruled out as an entry point for legal requirements. In contrast, nutrient budgets are highlighted as an environment indicator by the OECD and EU institutions.
Abiotic Transient Nitrite Occurrences from Nitrate Reduction through Goethite-Mediated Fe(III)/Fe(II) Cycle with Labile Organic Materials and Ammonia
Authors: Choi Hyeoksun , Oh Sanghwa
Published: April 2020

The abiotic reduction of NO3− to NO2−—coupled with the oxidation of labile organic materials such as citric acid, syringic acid and natural organic matter (NOM) and NH4+ through the goethite-mediated Fe(III)/Fe(II) cycle under anaerobic condition—was investigated at pH values of 4 and 7. The concentrations of the produced Fe2+ and NO2− were monitored. At a pH of 4, concentrations of Fe2+ increased, except for citric acid; no NO2− was detected. The reason why it was not detected is unclear. A possible reaction was the adsorption of NO2− onto goethite at pH < point of zero charge (pzc) of goethite (6.42) due to electrical attractive force. The maximum production of NO2− at a pH of 7 was in the order of citric acid >> syringic acid > NOM. However, Fe2+ was not detected at this pH even though Fe2+ should be required for NO2− production. To better understand of these phenomena, the adsorptive removal of Fe2+ and NO2− onto goethite was experimentally investigated. More than 90% of the produced Fe2+ and NO2− could be removed rapidly by adsorption onto the surface of goethite at pH 7 and 4, respectively. In addition, the reaction of Fe2+ with NO3− appeared to determine the overall reaction rate of the Fe(III)/Fe(II) cycle because of its relatively slow reaction rate. Using these results, we conclude that NO2− can be produced from NO3− reduction through Fe(III)/Fe(II) cycle with labile organic materials and ammonium at a pH of 7; especially, Fe(III)/Fe(II) cycle with citric acid results the maximum NO2− production higher than 600 μM for a long time (over 200 h) and then disappeared. But, the reasons for its disappearance were not addressed in this study.
Reflexões sobre a relação família e escola em territórios de vulnerabilidade social
Authors: Fraga de Almeida Prado Eduardo , Renato Rodrigues Carreiro Luiz , Vinícius de Araújo Marcos , Banti Bissoli Enzo , Torres Carrera Leonardo
Published: April 2020

Família e escola são consideradas instituições fundamentais para a garantia do direito à educação. São Paulo apresenta elevado índice de desigualdade, fato que reflete na garantia do direito à educação de qualidade em contexto de vulnerabilidade social. O objetivo deste ensaio residiu em investigar potencialidades, conflitos e impasses no envolvimento entre família e escola para a garantia do direito à educação. Para tanto, argumentamos em favor de que o arcabouço conceitual e a análise do discurso, tal como preconizadas por Michel Foucault, consistem em recursos teórico e metodológico pertinentes para a pesquisa em educação  haja vista a valorização da escuta dos discursos e das práticas daqueles  que integram a relação família e escola. Uma vez escutados, tais discursos e práticas poderão ser refletidos e criticados, gerando a possibilidade da criação de narrativas e estratégias voltadas à construção de educação de qualidade em contexto de vulnerabilidade social.
Bir Yaşam Tarzı Olarak Dilencilik: Hayattan Sahifeler
Authors: KÖSE Meryem
Published: April 2020

Hüseyin Rahmi Gürpınar, topluma içeriden bakarak gözlemleriyle dönemin yaşama yansıyan yönlerini eserlerinde işlemiştir. Onun eserlerinde toplumun pek çok kesiminde yaşamlarını sürdüren topluluklar hakkında bilgilere ulaşmak mümkündür. Toplumun farklı bir kesiminin yaşam şeklini yer yer mizah unsurlarıyla şiveler kullanarak, gerçekleri dönüştürerek okuyucuya sunmuştur. Hayattan Sahifeler romanında da toplumda farklı bir şekilde yer edinmiş ve bunu yaşam şekli olarak devam ettiren aynı zamanda çingene olan dilencilerin günlük yaşamının izlerini romanında ele almıştır. Gürpınar’ın gözlemleri neticesinde dilenciliğin bir meslek gibi yaşamlarının bir parçası olarak yer ettiği anlaşılmaktadır. Hayattan Sahifeler romanında, dilencilikle yaşamlarını devam ettiren bu sosyal sınıfın tek bir yönünü değil; roman kişilerinin insanlara, olaylara ve çevreye bakışını da görmek mümkündür. Eser, dilencilerin içinde bulundukları yaşam koşullarını, toplumun kültürel yapısını yansıtma noktasında öneme sahiptir.
Bu çalışmada, Hayattan Sahifeler romanında yazarın dilencilikle ilgili gözlemlerini okuyucuya ne şekilde sunduğunu ve toplumun bir parçası olan dilenciliğin yaşama nasıl yansıdığını, dilencilik estetiğinin nasıl olduğunu, dilencilik yaparken kullandıkları hilelerin ne olduğunu ve dilenciliğin diğer yönlerini incelemeye çalışacağız. Toplumun içinde yaşayan bir grubun yaşamı algılayışını daha iyi anlayabilmek için toplumbiliminden, psikolojiden, modadan faydalanılacaktır.
Acil Serviste Covid-19 ve Yönetimi
Authors: YURUMEZ Yusuf , ALAÇAM Mehmet
Published: April 2020

Covid-19’un en önemli özelliklerinden birisi insandan insana bulaşabilmesi ve bulaşın enfekte kişi ile yakın mesafede bulunma sırasında ortama saçılan damlacıklar yoluyla gerçekleşebilmesidir. Bu nedenle acil servisler en riskli alanlar içerisinde yer almaktadır. Covid-19 hastaları acil servise ayaktan veya ambulans ile başvurabilir. Ayaktan başvurular için acil servisin girişinde ya da dış kısmında bir triaj alanı ve acil servisin diğer alanlarından farklı bir yerde muayene alanı düzenlenmelidir. Resüsitasyon gerektiren ambulansla getirilen hastalar resüsitasyon alanına alınmalı, resüsitasyon gerektirmeyen hastalar muayene odasına alınmalı ve değerlendirilmelidir. Bu hastaların taburculuk veya yatış kararları klinik durumları dikkate alınarak verilmeli, yoğun bakım gerektiren hastalar bekletilmeksizin hızla yatırılmalıdır.

Abstract

One of the most important features of Covid-19 is that it can be transmitted from person to person, and the contamination can be achieved by the airbone droplets in close range infected person. For this reason, emergency services are the most risky areas. Covid-19 patients can apply to emergency service by using an ambulance or outpatient. For outpatient applications, a triage area must be organized at the enterance or outside the emergency service and the examination room should be located in the different area then the other departments of emercengy service. Patients brought by ambulance requiring resuscitation should be taken to the resuscitation area, patients not requiring resuscitation should be taken to the examination room and evaluated. The discharge or hospitalization decisions of these patients should be considered by their clinical situations and the patients that needs intensive care must be hospitalizated quickly without waiting.

Keywords: Covid-19, emergency room, infection.
Reconstrucción Mamaria Tardia Vd
Authors: Chaparro Enrique , Ochoa Julio , Geles José
Published: April 2020

Se presentan casos clínicos operados con la técnica de reconstrucción mamaria de grande dorsal Vd

, y se muestra un procedimiento quirúrgico que permite dar un mejor terminado en cuanto a simetría, volumen y proyección.

Se muestran 4 casos de reconstrucción tardía, de los cuales 2 fueron reconstrucciones tardías propiamente dichas y los otros 2 con reconstrucciones previas con complicaciones (un caso de necrosis previa de TRAM y otro con mal posicionamiento de la prótesis).

Se resalta la utilización de un sistema de cierre asistido por vacío (sistema de presión negativa), un sistema no invasivo y dinámico que ayuda a promover la cicatrización en el lugar de la herida, lo que favorece la reducción del área de la herida, eliminando el exceso de Áuidos y estimulando la angiogénesis.

Los 4 casos se atendieron en el Instituto Nacional de Cancerología de Colombia, la Clínica San Diego y el Hospital Departamental de Villavicencio.
Linfoma Linfoblástico cutáneo de células precursoras B: Una presentación infrecuente de los linfomas en niños
Authors: Suarez Matos Amaranto , Rincon Oyuela Giovanny , Paz Amador Kelly , Camila Prada María , Morales Naranjo Samuel
Published: April 2020

Los linfomas linfoblásticos primarios cutáneos son una enfermedad infrecuente que ocurre predominantemente en la edad pediátrica; y se presentan con lesiones cutáneas sin enfermedad sistémica identificable al momento del diagnóstico. La enfermedad tiene un comportamiento agresivo y el tratamiento debe basarse en protocolos derivados de manejo de las leucemias linfoblásticas agudas con lo cual se ha demostrado buenas tasas de supervivencia.

Los autores presentan el caso de una niña con un linfoma linfoblástico de células precursoras B primario cutáneo localizado en cara manejado con protocolo basado en BFM para leucemias linfoblásticas con buena evolución.
Jawaban midle tes ilmu sejarah dan pendidikan ips
Authors: Dina
Published: April 2020

Fakta sejarah yang menyatakan bahwa pendidikan telah ada sebelum sistem persekolahan ada. Hal ini dibuktikan pada masa Indonesia menerima agama, pengetahuan dan kebudayaan dari negara-negara tetangga seperti India. Pendidikan ini tertera pada peninggalan raja Mulawarman dan kerajaan-kerajaan lainnya yang membuktikan adanya tulisan-tulisan yang ditujukan sebagai peninggalan sejarah. Sehingga dari tulisan-tulisan itu orang-orang dapat mengetahui adanya kerajaan yang pernah berdiri. Selain itu banyak kitab-kitab suci yang ditulis, dalam kitab itu memberikan kebudayaan yang berupa memberikan korban dan menyanyikan pujian kepada dewa-dewa. Kitab ini berupa bahasa sanskerta dan huruf pallawa yang dijadikan sebagai bahasa resmi. Pendidikan pada masa abad ke 4-5 ini hanya ditujukan pada golongan yang memiliki kasta tinggi, terlihat pada masa itu tidak persekolahan khusus dibuat untuk mendapatkan pendidikan. Mereka hanya menjadikan aktivitas mereka untuk dijadikan pendidikan dan di pelajari terhadap hal-hal yang dilihat. Selain itu pendidikannya juga bisa berupa mata pencaharian mereka dengan melihat keadaan alam sekitar.
Generalization of Konhauser Polynomials
Authors:   Deptt. of Basic Science, Bundelkhand University Jhansi, India., Dassani* Mamta , Kushwaha Mukesh ,   Deptt. of Mathematical Scienes & Computer Applications, Bundelkhand University, Jhansi, India.
Published: April 2020

In this paper, we are showing study of biorthogonal polynomials associated with generalization of Laguere polynomials of Srivastava and Singhal [14]. It happens to generalized Konhauser. here we are trying to obtain the generating functions, recurrence relations, biorthogonality relations, integral representations and also bilinear and bilateral generating relations for the new class of biorthogonal system.
Influence Solubility Carbide to form Element on Mechanical Characteristic Doped Steel
Authors:   Senior Lecturer, Department of “General Technical Disciplines”, Namangan Engineеring and Technology Institute, Uzbekistan, Namangan., Rakhimov Ya. , Abduqakhhorov Z. ,   Associate Professor, Department of “General Technical Disciplines”, Namangan Engineеring and Technology Institute, Uzbekistan, Namangan., Imomkulov Sh. ,   Senior Lecturer, Department of “General Technical Disciplines, Namangan Engineеring and Technology Institute, Uzbekistan, Namangan.
Published: April 2020

The Problem of increasing to wear capability and longevity material worker mechanism agricultural machines is actual Defining importance in shaping the features to constructive toughness material worker mechanism agricultural machines has, as is well known, variation of the structured condition. Defining importance in shaping the features to constructive toughness material worker mechanism agricultural machines has, as is well known, variation of the structured condition. For this purpose article is studied structured conversions become under different type of the thermal processing, which vastly affect the specified characteristic.
Nonlinear Distortion Effects In Generalized Frequency Division Multiplexing
Authors:   Communication Systems, Adhiyamaan College of Engineering, Hosur, Tamil Nadu, India., Kaviya M. , Sumathi Dr.S. ,   Professor & Head, Department of ECE, Adhiyamaan College of Engineering, Hosur, Tamil Nadu, India.
Published: April 2020

Generalised Frequency Division Multiplexing (GFDM) is utilized in the fifth era cell organize as opposed to the Orthogonal Frequency Division Multiplexing (OFDM) since GFDM has numerous appealing highlights like heartiness towards recurrence particular blurring, simple execution and sensible, and so forth. GFDM has just a single cyclic prefix (CP) for a lot of images in a period OFDM it uses a solitary CP per image. Right now, research the effects of nonlinear mutilation on the different information numerous yield (MIMO) - GFDM framework when the sign is passed the HPA, which is displayed with sufficiency and stage contortion. The execution of the proposed strategy is resolved as far as range investigation, PAPR examination, and bit blunder rate (BER) investigation. The recreation results show that the proposed plan prevails with regards to making up for nonlinear contortions brought about by the HPA for huge contribution back-off (IBO) values.
Design of slit loaded Planar and Curved Patch Antenna
Authors:   ECE deptt, Maharaja Agrasen Institute of Techlogy, New Delhi, India., Kundu * Sumanta Kumar , Singhal P K ,   Electronics Deptt. 2Madhav Institute of Technology, Gwalior, M.P. India.
Published: April 2020

Slit loaded circularly polarized patch antenna embedded on planar structure and curvature structure were investigated. The curvature effect on slit loaded patch antenna determines the limiting value of radius of curvature to obtain circular polarization. At a certain radius of curvature (ROC) around 131.3 mm, circular polarization have been obtained with axial ratio band width around 15 MHz and return loss bandwidth around 56 MHz compared with 17 MHz and 65 MHz as that of planar structure. The beam width responsible for coverage of planar patch are 104 and 107 degree with respect to 84 degree and 124 degree of curved patch at phi = 0 and 90 degree respectively.
Female Foeticide and Gender Inequality in India: Issue of Attention
Authors:   Research Scholar, Department Of Economics, Dibrugarh University, Assam, Buragohain Pollypriya
Published: April 2020

In spite of a high rate of growth and ample government initiatives to maintain equality in case of gender, the gap between genders still exist in India. In India, based on their sex, gender variation is usually prescribed as the injustice or discrimination against women. Gender inequality limits women’s participation in various fields and it also hampers the life of the future generation also. Women are confronted with many hurdles in everywhere. Female foeticide is one of the worst types of discrimination against females where a female is refused her most essential and fundamental right, i.e. the right to live life. In India, female foeticide means outside of valid law, the abortion of a female foetus. In India, the recurrence of female foeticide is expanding day by day. In present day, it seems that the sex determination test leading to the practice of female foeticide overlooked and uncomplicated than before. Since ancient days, killing of female foetus is an extraordinary feature under the rule of patriarchy in Indian society. According to census report, the child sex ratio has decreased from 945 girls (0-6 years) per 1000 boys (0-6 years) in 1991 it is 927 girls per 1000 boys in 2001 to 919 girls per 1000 boys in 2011. The picture of female foeticide in North-East India is quite good as compared to the other states of India. As per the census 2011, Arunachal Pradesh has the highest child ratio among the Indian states i.e. 972 while Haryana has the lowest child sex ratio i.e. 834 per thousand males. According to decennial Indian census, the sex ratio in the 0 to 6 age group in India has risen from 102.4 males per 100 females in 1961, to 104.2 in 1980, to 107.5 in 2001, to 108.9 in 2011. On this background, here, an attempt has been made to examine the issue of female foeticide as an indicator of gender inequality in India. This paper is mostly descriptive in nature entirely based on secondary data.
Malware Detection using Deep Learning Methods
Authors:   Department of Computer Science and Engineering, LBSITW, Trivandrum, India., N.S Nourin , A Sulphikar ,   Department of Computer Science and Engineering, LBSITW, Trivandrum, India.
Published: April 2020

Rapid development of the internet leads the malware to become one of the most significant threads nowadays. Malware, is any kind of program or file which would adversely affect the computer users in a harmful way. Malware exist in different forms which includes worms, viruses in computer, Trojan horses, etc. These malicious contents can degrade the overall performance of the system. It includes activities like stealing, encrypting or deleting sensitive data, etc. without the consent of the user. Malware detection is a milestone in the field of computer security. For detecting malware many methods have been evolved. Researchers are mainly concentrated in malware identification methods based on machine learning. Malware can be detected in two ways. They are static approach and dynamic approach. This paper mainly deals with the current challenges faced by malware detection methods and also explores a categorized new method in machine learning. The methods discussed here are combined static and dynamic approach, random forest, Bayes classification. This work will help in cyber security area and also which will help the researchers to do efficient researches.
Determinants of Customer Satisfaction of Public Banks in Nepal
Authors:   Associate Professor, Tribhuvan University, Nepal Commerce Campus, Kathmandu, Nepal, Neupane Rajeswor
Published: April 2020

The study aims to analyze the factors influencing customer satisfaction in public bank of Nepal. The customers of public banks in Nepal are the population of this study. The 150 respondents have been as sample and analytical research design has been adopted in the study. The statistical tools such as mean, correlation and regression analysis have been used to analyze the data using SPSS – 20 version software. The research paper concluded that banks should focus more on increasing tangibles, responsiveness and assurance. The demographic variables age, gender, income level and education level do not have significant differences among the responses of participants.
Indian Literature is Hidden Source of Scientific Literature
Authors:   Founder & Advisor, Jayoti Vidyapeeth Women’s University, Jaipur (Rajasthan), India., Garg Dr. Panckaj
Published: April 2020

India is having a rich past in terms of literature, culture and knowledge. Our ancient literature is filled with secrets and mysteries which if unveiled would do wonders. With this project we made an attempt to explore the scientific knowledge hidden in our ancient literature, bring forward the references involved in these practices and analyze its relevance in today’s scenario.
The Effect of Debt Equity Ratio on Tax Planning Before and After Implementation of the Minister of Finance Regulation Number PMK-169/ PMK. 010/2015 on Registered Companies on the Indonesia Stock Exchange
Authors:   S.E., Ak., Master of Management Candidate, Faculty of Economics, University of Sriwijaya, Palembang, Indonesia, Pramajaya Jumaily , Adam Prof. Dr. Mohamad ,   S.E., M.E., Lecturer, Faculty of Economics, University of Sriwijaya, Palembang, Indonesia, Widiyanti Hj. Marlina ,   S.E., S.H., M.M., Ph.D, Lecturer, Faculty of Economics, University of Sriwijaya, Palembang, Indonesia, Fuadah Dr. Luk Luk ,   S.E., M.B.A., Ak., Lecturer, Faculty of Economics, University of Sriwijaya, Palembang, Indonesia
Published: April 2020

This study was conducted to analyze the effect of the debt-equity ratio (DER) on tax planning before and after the enactment of the Minister of Finance Regulation number PMK-169/PMK.010/2015. The data used in this study are financial reports submitted to the Indonesia Stock Exchange (IDX) for the period 2014-2017. Three hundred ninety companies were selected using a purposive sampling method with some requirements. The chosen samples are companies which have four finance reports in a row for the period, and those whose DER was more than zero (not negative) in 2014. The data used is cross-sectional panel data, using the data of liability and equity to measure capital structure, and earnings before tax (EBT) in which is the basis for imposing corporate income tax. The sample companies are divided into two groups to measure the impact of the regulation, namely groups of companies with DER above 4 and below 4. The results of the study show that the average DER of the company is 1.7 to 1.9, which means that only a few companies have DERs above 4:1 as specified in PMK-169. Furthermore, based on the results of the study it is known that both group of companies with DER above and below 4, the company's DER does not affect EBT before and after the implementation of PMK-169. The study implies that the application of PMK-169 by using a debt limitation rule is still not effective in minimizing potential tax loss due to debt interest expense of capital structure
The Effect In Changes of Persian Gulf Country Crude Oil Production, Usa Crude Oil Production, OECD Country Oil Consumption To The World Oil Price Changes
Authors:   Candidate Master of Management in Magister Management University of Sriwijaya, Indonesia., Nurmanto Wahyu , Adam Prof. Dr. Mohamad ,   S.E,. M.E, Lectures in Faculty Economic University of Sriwijaya, Indonesia., Widiyanti Hj. Marlina ,   S.E., S.H., M.M., Ph.D., Lectures in Faculty Economic University of Sriwijaya, Indonesia.
Published: April 2020

There are background issues has generated this study, which one from the global crude oil price get reduced to around 70% in the second semester of 2014. Several observations were associated with an imbalance between the pattern of supply and demand for crude oil. This study is purposed at examining the effect of the variable crude oil production from the Gulf Country and the USA, furthermore is the variable consumption of crude oil on changes in the price of WTI crude oil (West Texas Intermediate). The secondary data has obtained by U.S. agencies. Energy Information Administration (EIA). The results processed by multiple linear regression methods in the period of observation Q3 2001 - Q4 2018, the results describe that the variables of crude oil production from Saudi countries (Persian Gulf Country) give a significant negative result (β = -4.993; significant level 0.028), and for USA Oil production variable gives a significant positive result (β = 0.177; significant level 0,000) whereas OECD country consumption shows a positive result that is not significant for changes in crude oil prices (β = 1,926; significant level 0.058).
Enhancing the Strength Properties of Self-Compacting Concrete with Fiber Reinforcement
Authors:   Mtech Civil Structure, Kurukshetra University, Ambala, India., Sharma Sajan , Singh Gurvinder ,   Mtech Civil Structure, D.A.V. University, Jalandher, India.
Published: April 2020

Self-compacting concrete is one that is flow able by its own. The SCC is suitable for placing in dense reinforcement structures. It is a new generation performance concrete known for its outstanding deformity and high resistance to bleeding. The concrete is frail material which is comparatively tough in compression but fragile in tension. The tensile strength of concrete is improved by addition of fibers in the concrete mix. The addition of such fibers has negative consequence on the workability of concrete. Various types of fibers are used in concrete to provide the higher flexural strength and better tensile strength. In this research steel fibers are used to provide a better strength as compared with normal reinforced concrete. Steel fiber in SCC significantly improves its flexural strength, improved tensile properties, reduce cracking and improve durability. In this research the investigation of steel fiber in SCC to enhance the strength properties of SCC. The objective of the study was to determine different properties of SCC with steel fiber at different proportions. The experimental investigation was took on the freshly mixed and hardened properties of SCC of various mix with the different variations of fiber 0.25%, 0.50%, 0.75% and 1% by using Viscosity Modified Agent (VMA) 1.5% of cement material by using M25 grade of concrete. In this research a series of tests were carried out for workability like slump cone test, U funnel, V funnel, L box test on SCC to check freshly mix properties like flow-ability, filling-ability, and passing-ability and hardened properties like compressive strength, split-tensile strength and flexural strength respectively and test were conducted at the age of 7Days, 14Days, 28Days on the SCC. The advantage of adding steel fiber in self-compacting concrete is that it enhances its overall strength.
Deep Autoencoder-Based Image Compression using Multi-Layer Perceptrons
Authors:   Department of Statistics & Computer Science, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka., Bandara G.G.H.M.T.R. , Siyambalapitiya, R. ,   Department of Statistics & Computer Science, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka.
Published: April 2020

The Artificial Neural Network is one of the heavily used alternatives for solving complex problems in machine learning and deep learning. In this research, a deep autoencoder-based multi-layer feed-forward neural network has been proposed to achieve image compression. The proposed neural network splits down a large image into small blocks and each block applies the normalization process as the preprocessing technique. Since this is an autoencoder-based neural network, each normalized block of pixels has been initialized as the input and the output of the neural network. The training process of the proposed network has been done for various block sizes and different saving percentages of various kinds of images by using the backpropagation algorithm. The output of the middle-hidden layer will be the compressed representation for each block of the image. The proposed model has been implemented using Python, Keras, and Tensor flow backend.
ЗНАЧИМОСТЬ МОРФОНОЛОГИЧЕСКИХ ЭЛЕМЕНТОВ В ИМЕННОМ СЛОВООБРАЗОВАНИИ КАК ПРОЯВЛЕНИЕ ФУЗИОННОСТИ РУССКОГО ЯЗЫКА
Authors: IM Svetlana
Published: April 2020

В работе рассматривается роль таких морфонологических элементов в словообразовании, как ударение, альтернация фонем при выборе суффиксов в деминутивном словообразовании, характер зависимости между ними. Традиционно принято считать, что русское словообразование агглютинативно, так как доминирующая роль принадлежит аффиксу, а ударение и альтернация фонем ему подчинены. Русский язык фузионен по своим типологическим особенностям, так как именно в фузионных характеристиках, которые проявляют себя в виде чередования фонем, чередования ударения при склонении, спряжении и словообразовании, определяют типологические особенности русского языка. Поэтому в работе высказано предположение, что русское словообразование также фузионно. Фузионность находит своё выражение в том, что морфонологические характеристики производящего слова предсказывают выбор суффиксов, являющихся вариантами в рамках одной парадигмы алломорфов словообразовательного аффикса.
Исследование показало, что ударение, альтернация фонем и суффикс функционально равнозначны, так как суффикс также может задавать ударение и альтернант производного слова. Отсюда следует вывод, что альтернация алломорфов суффиксов, равно как и альтернации в основах, в том числе и правила выбора алломорфов, не являются объектами словообразовательного анализа, а относятся к морфонологии. Таким образом, гипотеза о функциональной равноценности ударения, чередования фонем и альтернации аффиксов находит свое подтверждение в описании словообразования деминутивов мужского рода с суффиксами – -ик, -ок (-ек), -ушек (-юшк, -ишек), -анёк (-енёк), что находит своё наглядное выражение в таблице выбора алломорфов суффикса.
To the anniversary of the professor Sergey Olegovich Mazurenko
Authors: Editorial Article
Published: April 2020

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The hereditary nephrotic syndrome in children and adults
Authors: Savenkova N. D.
Published: April 2020

Literature data indicate that as a result of achievements in medical genetics, the pathogenesis of the development of hormone-resistant isolated and syndromal nephrotic syndrome in pediatric and adult patients has been established. Clinical and genetic features of hereditary isolated or syndromal nephrotic syndrome in pediatric and adult patients are caused by mutations of genes encoding the main components of the glomerular basal membrane, slit diaphragm, structural and functional proteins of the podocyte. Clinical manifestations of hereditary nephrotic syndrome in pediatric and adult patients aged 0 to 70 years, progression to terminal renal failure from 5 months to 75–80 years, depending on genetic and clinical and morphological features, are established. Molecular Genetic testing in steroid-resistant isolated and syndromal nephrotic syndrome conducted before the start of cytostatic therapy and kidney biopsy in pediatric and adult patients is of important clinical significance for making decisions about the feasibility of kidney biopsy and immunosuppressive therapy evaluating the rate of progression to terminal renal failure, and choosing immunosuppressive therapy before kidney transplantation. The problem of early diagnosis of hereditary isolated and syndromal nephrotic syndrome in paediatric and adult patients facing domestic nephrology should be solved by the introduction of molecular genetic testing in nephrological practice.
Prenatal stress and its role in children's pathology: historical aspects and the current status of the question (review of literature)
Authors: Vyalkova A. A. , Frolov B. A. , Savelyeva E. V. , Chesnokova S. A.
Published: April 2020

The article presents an analysis of fundamental data on the problem of stress and its role in the development of stressful diseases. Scientific evidence on the role of stress in childhood pathology indicates the extreme pathogenetic significance of stress. It is proved that stress has three interconnected faces: stress as a link in the adaptation mechanism, stress as a link in the pathogenesis of diseases and adaptation to stressful situations as a natural prevention of stressful diseases. The scientific substantiation of the main evolutionarily determined role of stress as an adaptation link indicates the possibility of acquiring some degree of resistance to stressful situations. Prevention of reducing the excess of stress reactions and reducing the possibility of its transformation into a link in the pathogenesis of diseases limits the complex of mechanisms designated as a stress-limiting system. Important information is the development and coordination of the stress response, which is provided by a complex set of mechanisms of neuroendocrine regulation, united by the concept of “stress-implementing system”. The most common forms of stress are fetal hypoxia, metabolic disturbances, and toxic effects leading to uncontrolled oxidative stress at the cellular and tissue levels with the development of pregnancy complications, intrauterine growth retardation syndrome (IUGR), persistent changes and pathological conditions. As the fetus grows, the flow of oxygen and nutrients from the mother through the placenta increases, which is accompanied by an increased risk of the formation of pathologies of the brain, heart, liver and kidneys with the development of a multi-organ pathology in the subsequent life. It has been proven that oxidative stress combined with stress of malnutrition in the prenatal period increases the risk of endocrinopathies, kidney diseases, and a number of other chronic diseases in the adult state. In practical terms, the negative effects of stress are of particular interest. Early detection of psychosocial and sympathomimetic factors causing stress is the basis for the prevention of childhood pathology.
Clinical and genetic features of glomerulocystic kidney in childhood
Authors: Andreeva E. F. , Savenkova N. D.
Published: April 2020

The review provides historical information on the study of renal cystosis that occurs with glomerular cysts, discusses terminology issues and classification of diseases that occur with glomerulocystic kidney. The course features, diagnostic methods, treatment, and prognosis of renal glomerulocystosis in children, renal and extrarenal manifestations of two subtypes of hereditary glomerulocystic kidney disease: autosomal dominant glomerulocystic kidney disease associated with mutations of uromodulin (OMIM 609886) and familial hypoplastic glomerulocystic kidney disease associated with mutations of the HNF-1β (TCF2) gene (OMIM 137920). Diagnostic tetrad of familial hypoplastic glomerulocystic kidney disease, features of course and prognosis of HNF-1β-associated kidney disease with very early onset (VEO), MODY5 diabetes caused by HNF-1β mutation and 17q12 microdeletion syndrome in children were detected. According to the results of ultrasound examination (US), the fetus and newborn reveal hyperechogenicity of the kidney parenchyma, the volume of which is increased or corresponds to normal values. Renal cysts in glomerulocystic kidney are small, located in the cortical layer or subcapsularly, single or multiple, rarely diagnosed in the neonatal period. In young children, US shows a picture of increasing hyperechogenicity of the parenchyma with visualization of renal cysts in the cortical layer or subcapsularly, a decrease in the volume or asymmetry in the size of the kidneys. Urinary syndrome in glomerulocystic kidney in childhood is characterized by hematuria, microproteinuria, magniuria and uraturia in combination with hypostenuria and polyuria. Molecular genetic research reveals the mutation of genes responsible for the development of inherited diseases that occur with glomerulocystic kidney, and largely determines the prognosis and management tactics of the patient. A systematic approach is needed in the diagnosis and treatment of glomerulocystic kidney in children in order to slow the progression of chronic kidney disease and extrarenal manifestations, and to maintain continuity of observation of patients in pediatric and adult nephrological structures.
Comparison of first choice cytostatic therapy with calcineurin inhibitors and nucleotides synthesis inhibitors in children with steroid-sensitive, steroid-dependent nephrotic syndrome with steroid toxicity
Authors: Nyrkova P. A. , Savenkova N. D.
Published: April 2020

AIM. Evaluation in comparative study the efficiency of first choice cytostatic therapy with calcineurin inhibitor cyclosporine A and nucleotide synthesis inhibitormycophenolatemofetil (MMF)/mycophenolate sodium in children with relapsing and frequently relapsing steroid-dependent and steroid-sensitive nephrotic syndrome (NS) with steroid toxicity.

PATIENTS AND METHODS. Follow-up study with analysis of onset, clinical course and treatment includes 48 children ((29 boys (60 %) и 19 girls (40 %)) with relapsing and frequently relapsing NS, developedsteroid dependence and/or steroid toxicity.The efficiency of first choice cytostatic therapy with calcineurin inhibitor cyclosporine Ain 17 patients and nucleotide synthesis inhibitormycophenolatemofetil (MMF)/mycophenolate sodium in 31 patients is estimated in comparative study by analysis of 6 month remission rate and one year remission rate after treatment.

RESULTS. Statistically significant differences in 6 month and one year remission rate after first choice cytostatic therapy with MMF/ mycophenolate sodium and cyclosporine in children are established. Remission of NS during 6 months after MMF/ mycophenolate sodium treatment was in 67,7 % (in 21 from 31 patients) unlike of that after cyclosporine – in 29,4 % (in 5 from 17 patients) (р<0,05). Remission of NS during one year after MMF/ mycophenolate sodium treatment was in 58,1 % (in 18 from 31 patients) unlike of that after cyclosporine – 23,5 % (in 4 from 17 patients) (р<0,05). Cyclosporine toxicity was diagnosed in 5 from 17patients: increased creatinine (1),arterial hypertension (3), gingival hyperplasia (3) in treatment more than 12 months with reverse development after cancel. Side-effects after nucleotide synthesis inhibitor therapy was dignosed only in 1 from 31 patients (3,2 %) – lymphopenic crisis.

CONCLUSION. Remission of relapsing and frequently relapsing steroid-dependent and steroid-sensitive with steroid toxicity NS during 6 months after first choice cytostatic therapy with MMF/ mycophenolate sodium and cyclosporine in children was in 67,7 % and 29,4 % respectively, during one year in 58,1 % and 23,5 % respectively. As the result of comparative study remission during 6 months and one year was statistically significant more often in children after first choice cytostatic therapy with MMF/ mycophenolate sodium.