bluuebunny/crossref_metadata_2025 huggingface dataset:
Animal Abuse as a Type of Trauma: Lessons for Human and Animal Service Professionals
Authors: Randour Mary Lou , Smith-Blackmore Martha , Blaney Nancy , DeSousa Daniel , Guyony Audrey-Anne
Published: May 2019

Animal abuse frequently occurs at the same time and the same place as other types of violence, particularly family violence. Because of that close association, this article proposes that it is the responsibility of both animal service and human service professionals to be aware of its occurrence, understand its significance, and promote appropriate professional and policy responses to it. Research literature addressing the link between animal abuse and other forms of violence (“the link”) is discussed. Articles selected for review were published in a peer-reviewed journal, relevant to some aspect of the link between animal abuse and child abuse and/or domestic violence, used either a national or a longitudinal database, or relied on random sampling or a comparison group. If a study was retrospective or drawn from a convenience sample, it had to have been replicated by another study for inclusion. Finally, any measurement instruments used by the study under review must have had acceptable reliability and validity. Legal databases, such as LexisNexis, were used to identify legislation that has been passed and/or court cases that have been decided that were relevant to the topic of “the link.” Strong associations were found between domestic violence, child abuse, and animal abuse; animal abuse, whether witnessed or committed, is a form of trauma. Severe animal abuse as a predictor for severe domestic violence recently emerged as a promising association. However, some of these findings on “the link” have not been translated into practice, for example, domestic violence advocates and child protection workers frequently do not ask questions about pets in the family. At the same time, the past 20 years have seen an increase in state and federal legislation and policies that have been enacted, in part, because of the growing body of evidence on the link. Knowledge of the link also has influenced a number of court cases deciding parental rights. Moreover, awareness of the link is illustrated by the passage of pet protection orders for victims of domestic violence as well as the inclusion of pet abuse as a form of domestic violence. Human service and animal service professionals should articulate more ways in which they can communicate with one another, thus adding more information and resources to any intervention or treatment of family violence.
Extracellular-to-Intracellular Fluid Volume Ratio as a Prognostic Factor for Survival in Patients With Metastatic Cancer
Authors: Lee Jee Young , Ryu Han Sung , Yoon Sung Soo , Kim Eun Hye , Yoon Seong Woo
Published: May 2019

Purpose: This study aimed to investigate whether the extracellular-to-intracellular fluid volume (E/I) ratio can predict survival in patients with metastatic cancer. Methods: Clinical data were collected from April 2016 to March 2018. Patients aged ≥19 years with metastatic solid tumor were eligible. Bioimpedance analysis was used to assess body fluid distribution and the E/I ratio. Clinical characteristics, including laboratory test results and nutrition status according to the E/I ratio, were analyzed. Cox proportional hazards models and Kaplan-Meier analysis were used to identify risk factors for mortality. Results: In total, 87 patients were included in the study. The 87 patients were divided into 2 groups according to the median E/I ratio: a high E/I group (E/I ratio ≥1.0, n = 43) and a low E/I group (E/I ratio <1.0, n = 44). Poor performance status, fluid retention, malnutrition, elevation of C-reactive protein levels, and decreases in hemoglobin, albumin, and protein levels were significantly associated with the high E/I group. The median overall survival time was 1.6 and 12.5 months in the high E/I and low E/I groups, respectively ( P < .001). In the multivariate analysis, poor performance status, leukocytosis, fluid retention, and E/I ratio were independent prognostic factors, and the E/I ratio was the strongest prognostic factor predicting overall survival (hazard ratio = 3.49, 95% confidence interval = 1.75-6.96, P < .001). Conclusions: The E/I ratio can predict survival time in patients with metastatic cancer. More rigorous research is required to confirm this result.
The Greek Surgeon-Gynecologist Savvas Georgiadis (1857-1942) and the First Vaginal Reconstruction in Smyrna
Authors: Vladimiros Lazaros , Tsoucalas Gregory , Thomaidis Vasilios , Kakagia Despoina
Published: May 2019

The Greek surgeon-gynecologist Savvas Georgiadis from Phocaea in Asia Minor had performed in 1897 an innovative surgical operation in a young female patient, reconstructing her vagina. Having been educated both in Greece and France, specialized in gynecology, he became a famous surgeon in the Hellenic Hospital of Smyrna “Agios Charalampos,” where the operation was masterfully executed. Although among the pioneers in neovagina techniques, Georgiadis still is searching his place among the important figures in the history of plastic surgery.
Appearance and comfort properties considering yarn-spinning system and weave structure in worsted woven fabrics
Authors: Tahvildar Ali , Ezazshahabi Nazanin , Mousazadegan Fatemeh
Published: May 2019

Worsted woven fabrics are considered as a prominent sort of outwear garments; the comfort and appearance properties of which have attracted the attention of researchers and producers. The fabric constructional parameters and the characteristics of yarns used for weaving this group of fabrics can affect their efficiency, comfort, and esthetic characteristics. In this regard, 16 sets of worsted fabrics with four various weave structures (plain, twill 2/1, twill 2/2, and hopsack 2/2) and four groups of yarns which were spun in different yarn-spinning systems (Solo, Siro, single-ply ring, and two-ply ring) were studied. The analysis of results revealed that the open structure and the movability of yarns in the fabric can improve the crease recovery angle, flexibility, air permeability, and water vapor permeability of the fabrics, while decreasing the abrasion and pilling resistance. In addition, the yarns that are spun in various spinning systems, due to their different level of compactness and the location of fibers in the yarn structure, can significantly affect the comfort and appearance properties of the fabrics.
Pulmonary hypertension subjects exhibit right ventricular transient exertional dilation during supine exercise stress echocardiography
Authors: El‐Yafawi Rama , Rancourt David , Hacobian Melkon , Atherton Dennis , Cohen Mylan C. , Wirth Joel A.
Published: May 2019

Pulmonary hypertension is a condition with high morbidity and mortality. Resting transthoracic echocardiography is a pivotal diagnostic and screening test for pulmonary hypertension. The role of exercise stress echocardiography in the diagnosis of pulmonary hypertension is not well‐established. We studied right ventricular size changes during exercise using exercise stress echocardiography to assess differences between normal and pulmonary hypertension patients and evaluate test safety, feasibility, and reproducibility. Healthy control and pulmonary hypertension patients performed recumbent exercise using a bicycle ergometer. Experienced echocardiography sonographers recorded the following resting and peak exercise right ventricular parameters using the apical four chamber view: end‐diastolic area; end‐systolic area; mid‐diameter; basal diameter; and longitudinal diameter. Two cardiologists masked to clinical information subsequently analyzed the recordings. Parameters with acceptable inter‐rater reliability were analyzed for statistical differences between the normal and pulmonary hypertension patient groups and their association with pulmonary hypertension. We enrolled 38 healthy controls and 40 pulmonary hypertension patients. Exercise stress echocardiography testing was found to be safe and feasible. Right ventricular size parameters were all readily obtainable and all had acceptable inter‐observer reliability except for right ventricular longitudinal diameter. During exercise, healthy controls demonstrated a decrease in right ventricular end‐systolic area, end‐diastolic area, mid‐diameter, and basal diameter (P < 0.05). Conversely, pulmonary hypertension patients demonstrated an increase in right ventricular end‐systolic area, end‐diastolic area, and mid‐diameter (P < 0.05). These changes were unaffected by multivariate corrections. The sensitivity for pulmonary hypertension of an increase in right ventricular size was 97.2% with a negative predictive value of 95.2%. The ROC C‐statistic for increase in right ventricular size was 0.93. This transient exertional dilation (TED) of the right ventricle is observed in pulmonary hypertension patients but not in healthy controls. Recumbent right ventricular exercise stress echocardiography is a feasible and safe diagnostic test for pulmonary hypertension which warrants additional study.
Virginity-sparing management of hematocolpos with imperforate hymen: case report and literature review
Authors: Egbe Thomas Obinchemti , Kobenge Fidelia Mbi , Wankie Emmanuella Manka’a
Published: May 2019

Imperforate hymen results from failure of the endoderm of the urogenital sinus to completely canalize and has an incidence of 0.01% to 0.05%. This sometimes presents as a pelvic mass that compresses the bladder causing acute urinary retention. A 13-year-old girl was referred to our department with a history of primary amenorrhea, cyclic lower abdominal pain, abdominal–pelvic mass, constipation and acute urinary retention. She had an ultrasonography misdiagnosis of a huge ovarian mass before referral to our unit. On examination, the vagina was bulging and compressing the rectum. Repeat abdominal ultrasonography confirmed the diagnosis of hematometrocolpos. She underwent X-shaped hymenotomy with a favorable outcome. Diagnosis of imperforate hymen requires high suspicion index. Virginity-sparing surgery constitutes a good treatment option for cultural and religious reasons.
A case of an atypical resistant granulomatous HSV-1 and HSV-2 ulceration in an AIDS patient treated with intralesional cidofovir
Authors: Saling Christopher , Slim Jihad , Szabela Maria Elaine
Published: May 2019

We report a case of a granulomatous skin lesion in an AIDS patient whereby biopsy revealed both HSV-1 and HSV-2. This lesion was resistant to acyclovir and successfully treated with intralesional cidofovir without recurrence to date. This is the only known reported case of a granulomatous skin lesion in an HIV patient, whereby both HSV-1 and HSV-2 were isolated.
Experience of Homelessness Discrimination Among Emerging Adults: A Qualitative and Quantitative Analysis
Authors: Budescu Mia , Sisselman-Borgia Amanda , Torino Gina C.
Published: May 2019

The goal of the current study was to describe the experiences of discrimination based on homelessness among youth between the ages of 18 and 24 using both quantitative and qualitative data. Pilot data were collected on 85 homeless emerging adults in New York City recruited at drop-in centers and residential shelters. Quantitative results show the majority of the sample (81%) experienced at least one instance of homelessness discrimination in the past year. Over half the sample felt like others treated them as mentally inferior because of their homelessness, labeling them as crazy, irresponsible, and lazy. Additionally, nearly a third felt like they were ignored and/or treated unfairly by police officers and service providers. Qualitative data are used to supplement these results by detailing specific discriminatory experiences. Written responses about specific incidents reveal that youth feel dehumanized by friends and family as well as service providers and random people based on their homelessness. Results are discussed in the context of the unique challenges and universal developmental changes faced by this vulnerable population.
Complete Traumatic Spinal Cord Injury: Current Insights Regarding Timing of Surgery and Level of Injury
Authors: Wengel Paula Valerie ter , De Haan Yvette , Feller Ricardo E. , Oner F. Cumhur , Vandertop William Peter
Published: May 2019

Study Design:

A narrative literature review.

Objectives:

To review the neurological recovery patterns in traumatic spinal cord injury (tSCI) patients with a complete lack of motor and sensory function below the level of injury (ie, ASIA A [American Spinal Injury Association scale]), as well as the impact of level of injury and timing of surgical intervention.

Results:

Spontaneous neurological recovery in patients with complete tSCI differs per level of injury: patients with cervical and thoracolumbar tSCI recover ≥1 ASIA grade in 17.3% to 34.0% 1 year after injury, compared with 10.7% to 18.6% in thoracic tSCI. Surgical decompression within 24 hours has a beneficial effect on neurological recovery in patients with complete cervical tSCI, whereas this effect is less clear for thoracic and thoracolumbar tSCI. A 1- or 2-grade improvement in the ASIA scale does not necessarily result in functional recovery.

Conclusion:

In complete tSCI, the level of injury as well as surgical timing affect neurological recovery. There appears to be a beneficial effect of early surgical decompression in patients with complete cervical tSCI, more so than for thoracic and thoracolumbar tSCI. Frequently, the effect of surgical intervention is evaluated by an improvement in ASIA grade, but it is unclear whether this scale is sensitive enough to evaluate meaningful effectiveness of the intervention and desired outcome for patients with tSCI.
A Case Report of Multiple Myeloma Associated With Myeloperoxidase and Proteinase-3 Antibodies Posing a Diagnostic Dilemma
Authors: Cheta Jordana , Binder Michael
Published: May 2019

Multiple myeloma (MM) is a clonal proliferation of antibody-producing plasma cells that can precipitate renal injury through multiple mechanisms. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an inflammatory condition that can result in renal failure through mononuclear cell infiltration and consequent destruction of glomeruli. Several case reports have identified clinical situations where differentiating these entities has been challenging. Renal biopsy is an invaluable tool in differentiating between MM and AAV when clinical uncertainty exists. We report the case of an 85-year-old man who presented with a rapid decline in renal function and serologies positive for both MM and AAV. Renal biopsy findings confirmed the diagnosis of myeloma kidney and excluded vasculitis. This case highlights an unusual clinical scenario in which both proteinase-3 (PR-3) and myeloperoxidase (MPO) antibodies are positive. While these antibodies are both individually associated with ANCA vasculitis, they are seldom simultaneously positive. Our case would suggest that positive PR-3 and MPO antibodies should raise concern for an alternative diagnosis. Indeed, ANCA, PR-3, and MPO antibodies can all be positive in patients with monoclonal gammopathy in the absence of vasculitis. Our case underscores the value of renal biopsy in the setting of MM.
A Rare Case of Autoimmune Polyglandular Syndrome Type 2 in a Child With Persistent Fatigue
Authors: Smith Ryan Kenneth , Gerrits Peter M.
Published: May 2019

Adrenal insufficiency is a rare, potentially life-threatening condition whose diagnosis requires a high index of suspicion. Adrenal insufficiency may be primary, secondary, or tertiary with varied etiologies. Primary insufficiency may be part of a cluster of autoimmune diseases, referred to as autoimmune polyglandular syndrome(s) (APS). We describe a case of a 15-year-old male who presents to a local emergency department complaining of fatigue, fever, abdominal pain, nausea, and vomiting for a few days with a preceding viral illness. The patient was hyponatremic and hyperkalemic with skin hyperpigmentation, raising concern for adrenal insufficiency. Laboratory workup confirmed autoimmune primary adrenal insufficiency, with subsequent laboratory studies revealing autoimmune thyroiditis and celiac disease. Concomitant Addison’s and Hashimoto’s diseases led to a diagnosis of APS type 2. The patient was started on steroid replacement with rapid clinical improvement.
Distribution of High-Volume Ankle Arthroplasty Surgeons in United States Metropolitan Areas: Data from the 2012-15 Medicare Provider Utilization and Payment Release
Authors: Stein Brandon , Somerson Jeremy , Janney Cory , Panchbhavi Vinod
Published: May 2019

Category:

Total Ankle Arthroplasty

Introduction/Purpose:

Although demand for total ankle arthroplasty (TAA) is increasing, access to high-volume TAA surgeons may vary in different geographic regions. Given that low-volume TAA surgeons have demonstrated higher revision rates compared to higher-volume surgeons, access to these high-volume centers is a matter of patient and public health interest. The recent public release of the Medicare Provider Utilization and Payment Public Use File (MPUP-PUF) now allows for identification of individual providers who perform specific procedures. This study analyzed surgeon prevalence, distribution and factors that correlate with higher or lower high-volume surgeon population in metropolitan areas.

Methods:

The MPUP-PUF was reviewed for the 2012-2015 calendar years and data were extracted for all physicians who performed a minimum of eleven TAA procedures among traditional Medicare patients. These physicians were grouped into major metropolitan areas (population of one million or more). Average reimbursement, number of high-volume TAA surgeons and number of total procedures were calculated per major metropolitan area. The presence of an American Orthopaedic Foot and Ankle Society (AOFAS) fellowship and mean geographic reimbursement were analyzed for correlation with number of high- volume TAA surgeons.

Results:

The MPUP-PUF for 2012 to 2015 included 58 unique surgeons who performed a minimum of 11 TAA procedures in any of those calendar years, with a combined total 2,281 Medicare TAA procedures. Of these surgeons, 81% practice within major metropolitan areas with population greater than one million. Distribution among major metropolitan areas is highly unequal and higher numbers of surgeons are present in cities with an AOFAS fellowship.

Conclusion:

Access to high-volume ankle replacement surgeons among the Medicare population is lacking in multiple major metropolitan areas in the United States due to the uneven distribution of these surgeons. This method of analysis allows for opportunities to target training programs as well as placement of physicians to ensure access to high-volume ankle arthroplasty surgeons.
Asthma progression and mortality: the role of inhaled corticosteroids
Authors: O'Byrne Paul , Fabbri Leonardo M. , Pavord Ian D. , Papi Alberto , Petruzzelli Stefano , Lange Peter
Published: May 2019

Overall, asthma mortality rates have declined dramatically in the last 30 years, due to improved diagnosis and to better treatment, particularly in the 1990s following the more widespread use of inhaled corticosteroids (ICSs). The impact of ICS on other long-term outcomes, such as lung function decline, is less certain, in part because the factors associated with these outcomes are incompletely understood. The purpose of this review is to evaluate the effect of pharmacological interventions, particularly ICS, on asthma progression and mortality. Furthermore, we review the potential mechanisms of action of pharmacotherapy on asthma progression and mortality, the effects of ICS on long-term changes in lung function, and the role of ICS in various asthma phenotypes.

Overall, there is compelling evidence of the value of ICS in improving asthma control, as measured by improved symptoms, pulmonary function and reduced exacerbations. There is, however, less convincing evidence that ICS prevents the decline in pulmonary function that occurs in some, although not all, patients with asthma. Severe exacerbations are associated with a more rapid decline in pulmonary function, and by reducing the risk of severe exacerbations, it is likely that ICS will, at least partially, prevent this decline. Studies using administrative databases also support an important role for ICS in reducing asthma mortality, but the fact that asthma mortality is, fortunately, an uncommon event makes it highly improbable that this will be demonstrated in prospective trials.
National Trends in End-of-Life Care for Veterans With Advanced Cancer in the Veterans Health Administration: 2009 to 2016
Authors: Smith Claire E.P. , Kamal Arif H. , Kluger Monica , Coke Patty , Kelley Michael J.
Published: May 2019

PURPOSE:

It is imperative to provide quality end-of-life (EOL) care for patients with cancer. Although rates of hospice use within the Veterans Health Administration have improved, antineoplastic administration and intensive care unit (ICU) admission at the EOL, indicators of aggressive care, have not clearly declined over recent years.

METHODS:

We identified 32,665 veterans diagnosed with stage IV lung, colorectal, or pancreatic cancer who died between 2009 and 2016 using a novel EOL Dashboard Tool created from Veterans Administration Cancer Registry data. This EOL tool reports the incidence of antineoplastic drug use in the last 14 days of life, ICU admission in the last 30 days of life, and hospice admission or consult. Change from 2009 to 2016 was assessed using a repeated measures one-way analysis of variance with post hoc test for linear trend of time for individual cancers and two-way analysis of variance for all cancers combined.

RESULTS:

Antineoplastic use in the last 14 days of life declined from 6.8% in 2009 to 4.4% in 2016 ( P = .03). ICU admission in the last 30 days did not change significantly, from 13.3% in 2009 to 14.7% in 2016. The exception was patients with stage IV lung cancer, in whom ICU admissions increased from 12.9% to 16.2% ( P = .01). Patients using hospice services increased from 32.4% to 52.6% ( P < .01).

CONCLUSION:

Although antineoplastic administration at the EOL is declining for veterans with stage IV cancer, ICU admissions are unchanged and becoming more common in stage IV lung cancer despite increasing hospice use.
Undesirable Britons: South Asian Migration and the Making of a White Argentina
Authors: Bryce Benjamin
Published: May 2019

This article examines the history of South Asian immigration to Argentina before the First World War. The arrival of a relatively small group of Sikh laborers in 1912, alongside other Japanese and Chinese immigrants in the preceding decade, sparked a huge reaction from Argentine politicians and immigration bureaucrats. They restricted entry, pushed for labor market exclusion, and engaged in diplomatic exchanges with British imperial authorities. In their view, mass migration not only had the power to make a white, European nation but also threatened to undermine that same project. This article argues that the dominant vision of Argentina as a white nation was built on not only transatlantic immigration but also Asian exclusion. Drawing on archival research in Buenos Aires and London, it casts new light on both Argentine nationalism and the language of racial hierarchies mobilized in discussions of immigration.
Differentiated Durable Goods Monopoly: A Robust Coase Conjecture
Authors: Nava Francesco , Schiraldi Pasquale
Published: May 2019

The paper analyzes a durable goods monopoly problem in which multiple varieties can be sold. A robust Coase conjecture establishes that the market eventually clears, with profits exceeding static optimal market-clearing profits and converging to this lower bound in all stationary equilibria with instantaneous price revisions. Pricing need not be efficient, nor is it minimal (equal to the maximum of marginal cost and minimal value), and can lead to cross-subsidization. Conclusions nest both classical Coasian insights and modern Coasian failures. The option to scrap products does not affect results qualitatively, but delivers a novel motive for selling high cost products. (JEL C78, D42, L12)
Economia solidária no Estado do Amapá- Brasil: uma análise das estratégias de gestão e do mapeamento dos empreendimentos econômicos solidários
Authors: Santos Kátia Paulino dos , Gonçalves Hermínia Júlia De Castro Fernandes , Carvalho Maria Teresa Couceiro da Costa Sequeira e Sousa
Published: May 2019

Este artigo apresenta a realidade dos empreendimentos econômicos solidários do Amapá, por meio da análise do mapeamento realizado de 2010 a 2012 pela Secretaria Nacional de Economia Solidária (SENAES). Evidencia os principais avanços e as fragilidades na política de fomento no Estado. Utilizou-se pesquisa quanti-qualitativa, pesquisa de campo, por meio de entrevistas junto a gestores da economia solidária no Amapá, bem como análise de dados do mapeamento realizado pela SENAES. Estruturou-se este artigo em três partes: na primeira, tratou-se da política nacional de economia solidária capitaneada pela SENAES e das estratégias e características do mapeamento realizado no Brasil. Na segunda, realizou-se a apresentação da política de fomento à economia solidária no Estado do Amapá, delineada por entrevistas com os gestores dos principais órgãos de fomento. E na última parte, analisou-se o mapeamento empreendido no Amapá, que traçou o diagnóstico dos empreendimentos, seus perfis e principais resultados das políticas de desenvolvimento.
História da escola da Administração do Ceará: uma educação para o desenvolvimento?
Authors: Bezerra Mariana Maia , Fernandes Felipe Kaiser , Chaym Carlos Dias , Ipiranga Ana Sílvia Rocha
Published: May 2019

Esta pesquisa considerou a abordagem da História no contexto dos Estudos Organizacionais e da Administração, tendo como objetivo compreender a trama histórica da Escola de Administração do Ceará (EAC) que levou à constituição do Curso de Administração da Universidade Estadual do Ceará (UECE). Foi realizada a pesquisa em diferentes arquivos históricos. O acervo documental constituído e a análise histórica revelaram um evento complexo desde sua criação. Anunciamos um tema articulador, Educação para o Desenvolvimento, marcado por cooperações com agências e instituições norte-americanas, que moldou a organização política e pedagógica da escola, influenciando sua trajetória; e três períodos históricos, entre os anos de 1957 a 1979, que representam as dimensões temporais de experimentação, hibridismo e consolidação da identidade da EAC como curso de uma Universidade Estadual.
META-pipe cloud setup and execution
Authors: Agafonov Aleksandr , Mattila Kimmo , Tuan Cuong Duong , Tiede Lars , Raknes Inge Alexander , Bongo Lars Ailo
Published: May 2019

META-pipe is a complete service for the analysis of marine metagenomic data. It provides assembly of high-throughput sequence data, functional annotation of predicted genes, and taxonomic profiling. The functional annotation is computationally demanding and is therefore currently run on a high-performance computing cluster in Norway. However, additional compute resources are necessary to open the service to all ELIXIR users. We describe our approach for setting up and executing the functional analysis of META-pipe on additional academic and commercial clouds. Our goal is to provide a powerful analysis service that is easy to use and to maintain. Our design therefore uses a distributed architecture where we combine central servers with multiple distributed backends that execute the computationally intensive jobs. We believe our experiences developing and operating META-pipe provides a useful model for others that plan to provide a portal based data analysis service in ELIXIR and other organizations with geographically distributed compute and storage resources.
Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing
Authors: Butt Muhammad , Alyami Sabra , Nageeti Tahani , Saeed Muhammad , AlQuthami Khalid , Bouazzaoui Abdellatif , Athar Mohammad , Abduljaleel Zainularifeen , Al-Allaf Faisal , Taher Mohiuddin
Published: May 2019

Background: Ependymomas are glial tumors derived from differentiated ependymal cells. In contrast to other types of brain tumors, histological grading is not a good prognostic marker for these tumors. In order to determine genomic changes in an anaplastic ependymoma, we analyzed its mutation patterns by next generation sequencing (NGS).

Methods:  Tumor DNA was sequenced using an Ion PI v3 chip on Ion Proton instrument and the data were analyzed by Ion Reporter 5.6.

Results: NGS analysis identified 19 variants, of which four were previously reported missense variants; c.395G>A in IDH1, c.1173A>G in PIK3CA, c.1416A>T in KDR and c.215C>G in TP53. The frequencies of the three missense mutations (PIK3CA c.1173A>G, KDR c.1416A>T, TP53, c.215C>G) were high, suggesting that these are germline variants, whereas the IDH1 variant frequency was low (4.81%). However, based on its FATHMM score of 0.94, only the IDH1 variant is pathogenic; other variants TP53, PIK3CA and KDR had FATHMM scores of 0.22, 0.56 and 0.07, respectively. Eight synonymous mutations were found in FGFR3, PDGFRA, EGFR, RET, HRAS, FLT3, APC and SMAD4 genes. The mutation in FLT3 p.(Val592Val) was the only novel variant found. Additionally, two known intronic variants in KDR were found and intronic variants were also found in ERBB4 and PIK3CA. A known splice site mutation at an acceptor site in FLT3, a 3’-UTR variant in the CSF1R gene and a 5’_UTR variant in the SMARCB1 gene were also identified. The p-values were below 0.00001 for all variants and the average coverage for all variants was around 2000x.

Conclusions: In this grade III ependymoma, one novel synonymous mutation and one deleterious missense mutation is reported. Many of the variants reported here have not been detected in ependymal tumors by NGS analysis previously and we therefore report these variants in brain tissue for the first time.
The long road to protect infants against severe RSV lower respiratory tract illness
Authors: Jares Baglivo Sofia , Polack Fernando P
Published: May 2019

Severe respiratory syncytial virus (RSV) lower respiratory tract illness (LRTI) in infants has proven challenging to prevent. In the last 50 years, conceptually different approaches failed to evolve into viable preventive alternatives for routine use. Inactivated RSV vaccine (that is, formalin-inactivated RSV) elicited severe LRTI in RSV-infected toddlers pre-immunized as infants; early purified F protein approaches in pregnant women failed to elicit sufficient immunity more than a decade ago; a second-generation monoclonal antibody (mAb) of high potency against the virus (that is, motavizumab) caused severe adverse reactions in the skin, and owing to lack of efficacy against RSV subgroup B, an extended half-life mAb targeting site V in the RSV fusion protein (that is, REG2222) did not meet its primary endpoint. In the meantime, two protein F vaccines failed to prevent medically attended LRTI in the elderly. However, palivizumab and the recent results of the Novavax maternal immunization trial with ResVax demonstrate that severe RSV LRTI can be prevented by mAb and by maternal immunization (at least to a certain extent). In fact, disease prevention may also decrease the rates of recurrent wheezing and all-cause pneumonia for at least 180 days. In this review, we discuss the history of RSV vaccine development, previous and current vaccine strategies undergoing evaluation, and recent information about disease burden and its implications for the effects of successful preventive strategies.
Optimized functional annotation of ChIP-seq data
Authors: Khomtchouk Bohdan B. , Koehler William C. , Van Booven Derek J. , Wahlestedt Claes
Published: May 2019

Different ChIP-seq peak callers often produce different output results from the same input. Since different peak callers are known to produce differentially enriched peaks with a large variance in peak length distribution and total peak count, accurately annotating peak lists with their nearest genes can be an arduous process. Functional genomic annotation of histone modification ChIP-seq data can be a particularly challenging task, as chromatin marks that have inherently broad peaks with a diffuse range of signal enrichment (e.g., H3K9me1, H3K27me3) differ significantly from narrow peaks that exhibit a compact and localized enrichment pattern (e.g., H3K4me3, H3K9ac). In addition, varying degrees of tissue-dependent broadness of an epigenetic mark can make it difficult to accurately and reliably link sequencing data to biological function. Thus, there exists an unmet need to develop a software program that can precisely tailor the computational analysis of a ChIP-seq dataset to the specific peak coordinates of the data and its surrounding genomic features. geneXtendeR optimizes the functional annotation of ChIP-seq peaks by exploring relative differences in annotating ChIP-seq peak sets to variable-length gene bodies. In contrast to prior techniques, geneXtendeR considers peak annotations beyond just the closest gene, allowing users to investigate peak summary statistics for the first-closest gene, second-closest gene, ..., nth-closest gene whilst ranking the output according to biologically relevant events and iteratively comparing the fidelity of peak-to-gene overlap across a user-defined range of upstream and downstream extensions on the original boundaries of each gene's coordinates. We tested geneXtendeR on 547 human transcription factor ChIP-seq ENCODE datasets and 198 human histone modification ChIP-seq ENCODE datasets, providing the analysis results as case studies. The geneXtendeR R/Bioconductor package (including detailed introductory vignettes) is available under the GPL-3 Open Source license and is freely available to download from Bioconductor at: https://bioconductor.org/packages/geneXtendeR/
Analytical Available Bandwidth Estimation in Wireless Ad-hoc Networks Considering Mobility in 3-Dimensional Space
Authors: Mukta . , Gupta Neeraj
Published: May 2019

Estimation of available bandwidth for ad hoc networks has always been open and active challenge for the researchers. A lot of literature is proposed in the last 20 years to evaluate the residual bandwidth. The main objective of the work being admission of new flow in the network with the constraint that any existing current transmission is not affected. One of the prime factors affecting the estimation process is the collision among packets. These collisions trigger the backoff algorithm that leads to wastage of the usable bandwidth. Although a lot of state of art solutions were proposed, but they suffer from various flaws and shortcoming. Other factor contributing to the inaccuracy in existing solution is the mobility of nodes. Node mobility leads to instability of links leading to data losses and delay which impact the bandwidth. The current paper proposes an analytical approach named Analytical Available Bandwidth Estimation Including Mobility (AABWM) to estimate ABW on a link. The major contributions of the proposed work are: i) it uses mathematical models based on renewal theory to calculate the collision probability of data packets which makes the process simple and accurate, ii) consideration of mobility under 3-D space to predict the link failure and provides an accurate admission control. Extensive simulations in NS-2 are carried out to compare the performance of the proposed model against the existing solutions.
Consumer Choice Under Limited Attention When Alternatives Have Different Information Costs
Authors: Huettner Frank , Boyacı Tamer , Akçay Yalçın
Published: May 2019

Consumers often do not have complete information about the choices they face and, therefore, have to spend time and effort acquiring information. Because information acquisition is costly, consumers trade off the value of better information against its cost and make their final product choices based on imperfect information. We model this decision using the rational inattention approach and describe the rationally inattentive consumer’s choice behavior when the consumer faces alternatives with different information costs. To this end, we introduce an information cost function that distinguishes between direct and implied information. We then analytically characterize the optimal choice probabilities. We find that nonuniform information costs can have a strong impact on product choice, which gets particularly conspicuous when the product alternatives are otherwise very similar. There are significant implications on how a seller should provide information about its products and how changes to the product set impacts consumer choice. For example, nonuniform information costs can lead to situations in which it is disadvantageous for the seller to provide easier access to information for a particular product and to situations in which the addition of an inferior (never chosen) product increases the market share of another existing product (i.e., failure of regularity). We also provide an algorithm to compute the optimal choice probabilities and discuss how our framework can be empirically estimated from suitable choice data.
Continuing the conversation
Authors: Dunkley-Bent Jacqueline
Published: May 2019

Continuity of carer has been a long-standing ambition in midwifery, so why does it remain the dominant conversation? Jacqueline Dunkley-Bent explains
Planning for pregnancy
Authors: de Barra Deirdre
Published: May 2019

The charity Tommy's is launching a new campaign, #AreYouReady?, to improve pre-conception care and information. Deirdre de Barra explains the importance of informed pregnancy planning
Pregnancy-specific health anxiety: symptom or diagnosis?
Authors: Rathbone Amy Leigh , Prescott Julie
Published: May 2019

Anxiety is an innate human response to situations that cause fear, worry or concern. One such type is health anxiety. Health anxiety is a term derived from hypochondriasis and divided into two disorders: illness anxiety disorder and somatic symptom disorder. Symptoms can range from mild-to-moderate expressions of worry to clinical diagnoses. Previous research has shown pregnancy-specific anxiety to be an autonomous anxiety disorder. When a woman conceives, immediate somatic changes are experienced, and although all pregnancies are different, these changes could cause either illness anxiety disorder or somatic symptom disorder. This review explores the possibility of pregnancy-specific health anxiety in greater detail.
Eating disorders: knowing the signs
Authors: Deverick Julie
Published: May 2019

Eating disorders are not only damaging to general health, but heavily impact oral health, too. Dental hygienist Julie Deverick reveals how
Why we should all ♥ Instagram
Authors: Middleton Anna
Published: May 2019

London hygienist Anna Middleton investigates what social media has to offer the world of dentistry
Hay fever, allergies and the joys of summer!
Authors: Wake Charlotte
Published: May 2019

Charlotte Wake suggest dental teams should spare a thought for those patients who struggle as we swing into a new season and the pollen count hits a high
Sexual health advice for MSM and WSW in general practice
Authors: Kelsey Sally
Published: May 2019

Men who have sex with men and women who have sex with women need specialised health considerations regarding their sexual health. Sally Kelsey describes what these health needs are and what practice nurses can do to ensure health inequalities are reduced

People who identify as lesbian, gay or bisexual (LGB) make up a minority of the population, but carry a large burden of sexually transmitted infections (STIs). Some behaviours among men who have sex with men lead to an increased risk of some STIs and women who have sex with women have specific health needs. While specialist sexual health services are well placed to provide services for these patients, many people choose not to or are not able to access these services. Therefore, primary care has a prime opportunity to offer advice and screening for asymptomatic individuals, and to offer opportunistic advice. Health professionals should be educated in these specific health needs, develop awareness of patient risks and discuss sexual behaviours and risks in an open and non-judgmental way.
Dementia care in the community: what can you do to help?
Authors: Society Alzheimer’s
Published: May 2019

As Dementia Action Week runs from 20–26 May, the Alzheimer’s Society explores how much awareness needs to be raised in community healthcare and how practice nurses are in the best position to inform patients of the many life-changing services available to them
The anti-vaccination movement: a concern for public health
Authors: Gilroy Rebecca
Published: May 2019

As the number of measles cases continues to rise in the UK and across the globe, now is the time to question why vaccination rates are not as high as they could be. Rebecca Gilroy investigates the influence of the anti-vaccination movement online and on social media
Research Roundup
Authors: Winter George
Published: May 2019

George Winter provides an overview of recently published articles that may be of interest to practice nurses. Should you wish to look at any of the papers in more detail, a full reference is provided.
MEASURING CORPORATE SOCIAL RESPONSIBILITY PERFORMANCE: A COMPREHENSIVE AHP BASED INDEX
Authors: Bahurmoz Asma Mohammed
Published: May 2019

Although there is no agreed upon universal definition of corporate social responsibility (CSR), organizations are often ranked in terms of their CSR performance. However, two glaring gaps have been identified in the CSR literature. First, evaluation methodologies are questionable and often lack a scientific basis and second, stakeholder representation is not made explicit or is missing altogether. This paper contributes to the CSR literature by constructing a CSR index based on the Analytic Hierarchy Process (AHP), as well as ensuring that stakeholder judgments are an integral part of the constructed index. Furthermore, the developed index is implemented to measure CSR performance in a business setting. An AHP-based CSR index is developed for the services sector in Saudi Arabia to serve as a case study. The developed index is used to measure CSR performance in over forty corporations. The paper adds to the existing literature by providing insight into how the Saudi corporations perceive and practice CSR. It concludes that a systematic usage of the developed AHP-based CSR index would facilitate corporations to adopt a more responsible and measurable behavior, while it offers government institutions the option to rank corporations in terms of their CSR practices in a scientific and transparent manner.
Clarity at twilight
Authors: McNally Scarlett
Published: May 2019

Scarlett McNally reflects on what’s become clear, as a diagnosis of myeloma potentially brings her surgical career to a premature close.
Surgeon photographers
Authors: Court Stephen
Published: May 2019

Stephen Court speaks with three surgeons to explore the relationship between their photography and profession.
Aspects of disclosure
Authors: Wheeler Robert
Published: May 2019

Each month we take a close look at a recent legal case with implications for the surgical profession.
A obra de arte musical: uma pergunta para Heidegger
Authors: Drucker Claudia
Published: May 2019

O pensamento de Heidegger sobre as artes considerou a poesia, em primeiro lugar, e depois as artes plásticas. A música quase não é citada. De obras e compositores afirma‑se que não alcançaram relevância histórica (no sentido fundacional que o pensador dá aos termos). Ao mesmo tempo, o pensamento de Heidegger sobre a obra de arte não poderia deixar de abarcar a música e influenciar abordagens posteriores, mesmo que maneira negativa, desconstruindo certezas sedimentadas. No presente artigo, tento expor a dupla direção que caracteriza as linhas principais do pensamento heideggeriano sobre a música, bem como algumas de suas implicações.
Escenarios y razones del antipedagogismo actual
Authors: Gil Cantero Fernando
Published: May 2019

El objetivo de este artículo estriba en analizar algunas de las razones del desprestigio actual del conocimiento pedagógico. En primer lugar, se muestran algunos ejemplos nacionales e internacionales sobre el ambiente cultural de rechazo hacia la Pedagogía y los pedagogos. En segundo lugar, se presenta una revisión de las principales posiciones en juego sobre el antipedagogismo. En tercer lugar, se analizan algunas de las razones que pueden explicar la actual corriente antipedagógica. Estas razones se basan en posibles errores o excesos de cierta Pedagogía. Razones políticas centradas en la excesiva polarización ideológica entre escuela tradicional y progresista o nueva. Razones gnoseológicas centradas en separar en exceso la perspectiva educativa y el aprendizaje de las áreas culturales. Y, por último, razones normativas centradas en identificar la educación con la vida y las experiencias subjetivas.
A proszociális viselkedés egyes altípusainak megjelenése kiscsoportos óvodás gyermekek viselkedésében
Authors: Hegedűs Szilvia
Published: May 2019

A proszociális viselkedések sokféle módon megjelenő reakciók, amelyek egy másik személy problémás helyzete okán valósulnak meg, és szándékuk szerint a felmerülő szituációk megoldására, a másik negatív mentális állapotának csökkentésére irányulnak. Nemzetközi szinten több vizsgálat zajlott e készségek feltárásáról, valamint fejlesztéséről, azonban a hazai kutatások száma elenyésző. A magyar kutatások többségében indirekt módszereket alkalmaznak e viselkedések vizsgálatára, főként azon személyek kikérdezésével, akik a gyermekek nevelésében aktívan részt vesznek (szülők, pedagógusok). A vizsgálatban 189 kiscsoportos óvodás gyermek vett részt. Kutatásunk célja az óvodás gyermekek néhány proszociális viselkedésének (segítés, megosztás, vigasztalás) vizsgálata volt hétköznapi szituációkat bemutató direkt vizsgálati módszerekkel. A szituációk során a gyermekeknek egy problémás helyzet beazonosítása után, valamely proszociális viselkedés megvalósításával a másik személy negatív érzelmi állapotának csökkentése, és helyzetének megoldása volt a feladata. Kutatási eredményeink azt mutatták, hogy a gyermekek a bemutatott szituációkban az esetek többségében proszociális viselkedésekkel reagáltak. A másik személy problémás helyzetének észlelését követően az óvodások segítő viselkedése nagy arányban jelent meg, valamint a birtokukban lévő dolgokat is jellemzően megosztották a felnőttel, amennyiben úgy vélték, hogy ezzel kielégíthetik a másik szükségleteit. Ezzel ellentétben negatív affektív állapot megjelenésekor a gyermekek jellemzően nem reagáltak proszociális viselkedéssel, vagyis nem törekedtek arra, hogy vigasztalással változtassanak a másik személy állapotán. Az eredmények rámutattak arra, hogy az óvodákban szereplő problémás helyzetek kezelése a gyermekek számára eltérő nehézségű lehet, valamint több tényező is befolyásolhatja ezen készségek működését. Mindezek további kutatások alapjául szolgálhatnak, valamint egy későbbi fejlesztő programhoz is kellő információt adhatnak.
GRYNFELTT HERNIA INITIALLY DIAGNOSED AS LIPOMA: A CASE REPORT
Authors: Machado Raniery Soares Sobreira , Brito Raquel Carlos de , Frutuosos Jairo Fernandes , Sant'Anna André Luís , Magalhães Francisco Anselmo , Machado Vital Maria dos Santos Sobreira , Batista Hermes Melo Teixeira
Published: May 2019

Abstract: Lumbar hernia is a disease that presents unsual and difficult diagnosis. It is most prevalent in males and the elderly. It is presented the case of a 70-year-old male patient with previous trauma in the lumbar region 30 years ago and since then presented as a tumor in that region. He asked for a medical help and, initially, his case was diagnosed as a lipoma, but then Grynfeltt's hernia was identified and properly repaired.  Keywords: Lumbar hernia; Grynfeltt hernia; superior lumbar hernia