bluuebunny/crossref_metadata_2025 huggingface dataset:
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF 3-BROMOBENZALDEHYDE NICOTINIC ACID HYDRAZONE AND IT’S Co(II), Cu(II), Mn(II) AND Ni(II) COMPLEXES
Authors: OJO A. S. , MAMMAN S. , UKOHA P. O.
Published: August 2022

Acyl hydarazones and other hydrazones derivatives are of immense biological importance as a result of their antibacterial, antifungal, antiinflammatory properties and coordination Chemistry. The ligand was prepared by refluxing nicotinic acid hydrazide and 3-bromobenzaldehyde in ethanol, the complexes were synthezed by mixing ethanolic solutions of the metal salts with the hydrazone. The ligand and complexes were characterized on the basis of uv-visible, FTIR, melting point, conductivity, magnetic susceptibility, metal analysis and mole ratio, antimicrobial activities were determined. The ligand and complexes formed are high melting point crystalline solids. Thermodynamic stability study showed that the complexes are stable with stability constants between 2.84 x 105 – 2.21 x 107 while the solution studies gave 1:2 metal to ligand ratio. Infrared spectra data are diagnostic of bidentate coordination of the ligand via carbonyl oxygen and azomethine nitrogen atoms as result of the negative shift in the (C=O) and (C=N) bands. Effective magnetic moment of the complexes is 5.62 B.M, 4.02 B.M. and 1.81 B.M. for Manganese, Cobalt and Copper complexes respectively, the nickel complex is diamagnetic. Electronic spectra of the ligand indicate n * transitions, transition in the manganese complex is spin and orbital forbidden with very low molar absorptivity, nickel complex gave two bands assigned to 3A2g(F)  3T1g(F) and 3A2g(F)  3T1g(P) transition, cobalt complex gave one electronic band assigned to 4T1g(F)  4A2g transition. Copper complex gave one band, assigned to 2Eg    2T2g transition. On the basis of magnetic and electronic spectral of the isolated complexes octahedral geometry has been proposed for the Mn(II), Co(II) and Cu(II) complexes and square planar for the Ni(II) complex. The activities of the complexes against most of the microorganisms were enhanced compared to those of their parent ligand, with some promising potential when compared to the control drugs.
EXCHANGE RATE FLUCTUATIONS, FOREIGN DIRECT INVESTMENT AND FINANCIAL DEVELOPMENT IN NIGERIA
Authors: FASINA OLUWADAMILOLA TOSIN
Published: August 2022

This study examines the relationship among exchange rate fluctuations, foreign direct investment, and financial development in Nigeria over the period 1970 to 2020. The study utilizes the Autoregressive distribution lag estimation technique to examine the relationship among the variables of interest. The results of the study show that foreign direct investment has a positive relationship with the level of exchange rate fluctuations, however, trade openness and inflation have a negative effect on the flow of foreign direct investment into Nigeria. The study observed that the interactive effect of exchange rate fluctuations and foreign direct investment has a negative effect on the level of financial development in Nigeria. Therefore, this study recommends that there is a need for the Nigerian government to implement policies aimed at improving the interaction between the level of exchange rate and foreign direct investment which in turn would have a positive impact on the development of the financial sector.
TALENT MANAGEMENT AND ORGANIZATIONAL PERFORMANCE IN SELECTED MANUFACTURING FIRMS IN ENUGU STATE NIGERIA
Authors: AUGUSTINE ANICHEBE NNAEMEKA , EKWUTOSI ONUOHA, CHARITY , NDUBUISI ANYANWU KINGSLEY , ANYANWU PASCHAL, CHIMA
Published: August 2022

The Study focuses on talent management and organizational performance in selected manufacturing firms in Enugu State Nigeria. Specifically the study aimed to pursue the following objectives to identify the effect of talent planning on organizational performance, ascertain the extent to which employee development affect organizational performance and determine the effect compensation/reward on organizational performance, . The study had a population size of (2672) of employees of the selected two manufacturing firms (Nigeria Breweries plc and Innosson technical industry) and sample of 400 were derived using Yamane, Taro [1] sample size determination formula. The total number of 400 copies of the questionnaire was distributed while 385 copies were properly filled/returned & used while 15 copies were not properly filled. Survey research design was adopted for the study. Three hypotheses were tested using simple linear regression. The findings indicated talent planning has a significant positive effect on organizational performance. Employee development significantly affects organizational performance. Compensation/reward significantly affect organizational performance. The study recommends that Manufacturing firms should establish an equity reward system among employees and at the same time pay them at when due, which will motivate them to put in their best in discharging their duties.
EVALUATING A RELIABLE MICROCONTROLLER SYSTEM FOR SITTING BALANCE TREATMENT
Authors: KWAK ALLISON
Published: August 2022

Rationale: As time spent seated increases, balanced sitting posture is more important now than ever before. Unbalanced sitting posture deteriorates spinal curvature, which can predispose the pathological discs in the back, leading to irreversible damage. An IoT platform was connected to a chair with pressure sensors attached for this microcontroller device that continuously collected the user's sitting data.

Procedures: An Arduino Yun microcontroller board was used to monitor sitting posture with the balance feedback system (BFS), which consisted of reliable pressure sensor kits and an IoT platform. Four pressure sensors were coordinated to acquire sitting pressure using the software algorithm, and data was sent to the Thingspeak server and plotted in real-time. The testing session was divided into three stages to verify the system's performance: pre-BFS stage, BFS-Treatment stage, and post-BFS stage. Each stage consisted of the volunteer sitting in the chair for an hour daily for five consecutive days. During the pre-BFS stage, the volunteer sat in the chair to measure their natural seated pressure distribution without using the application. During the BFS-Treatment stage, the volunteer sat in the chair using the application to review pressure data. For the post-BFS stage, the volunteer did not have access to the application in hopes that they could apply their learnings from the previous stage to sit with corrected posture.

Conclusions: The study concluded that the BFS could monitor the user’s sitting posture and help improve posture to maintain a balanced state. This study can contribute to the prevention of various sitting diseases.
A Study on Elastic Logistics in Supply Chain Management
Authors: Sengottuvelu C. , Habib Md. Wahidul , Dhivya P.
Published: August 2022

This research paper highlights the emerging developments in the logistics of supply chain management. In this study, the emerging logistics trends were highlighted. Authors have identified 15 logistics trends in the coming years. Elastic logistics was focused mainly considering current pandemic situations. Secondary data and published research articles were reviewed and used. Elastic logistics is all about by building the flexibility to expand and shrink according to the demands of the market in the supply chain during a given time frame. Further, in this study, the purchasing and supply chain management emerging strategies, thrust areas and , logistics & supply chain management linkages, emerging logistics trends, role of elasticity in warehouse operations, and benefits of elastic logistics in businesses. Adoption of elastic logistics philosophies is also discussion. In this context, elastic logistics concept adopted by a company in India also discussed. The case study is about Elastic Run Startup Company’s success story. This paper is an outcome of qualitative study. It is concluded that further empirical research should be conducted. Keywords: Elastic logistics, logistics trends, supply chain management, warehousing,
Management of Electric Energy in Stand-alone Off-grid Solar PV System
Authors: Ahmed Md Tofael , Rashel Masud
Published: August 2022

The stand-alone solar photovoltaic system has different kinds like on-grid and off-grid. This paper deals with the analysis, design and control of electric energy with different load profiles in off-grid stand-alone solar photovoltaic systems. The management of electric energy varies according to various load profiles. In here, the loads are considered as only DC loads. This paper shows three different dc load profiles. The goal of the management is to show and control the loads according to the load profiles and observe the outputs in MATLAB/Simulink. The simulation of the system has been developed in MATLAB/Simulink. Here, a simple stand-alone solar photovoltaic model has been used which carries PV module, charge controller, management strategy, battery, loads and a monitoring box to monitor the load profiles. This work introduces the procedure of how to control with different load profiles and what are the outputs. Finally, experimental results and related figures are shown to verify the effectiveness of the proposed energy management strategy.
Professional stress in special integrated education
Authors: Comăneanu Maria-Marinela
Published: August 2022

The professional activity carried out by a school counselor teacher may seem like an easy job for some specialists, but for most of them, their job involves many difficulties. The professional stress of school counselors is experienced because their work requires face-to-face communication with people, activities that involve knowing, assessing and addressing various types of problems of all categories of students, who can be described as stable signs of maladaptation to school requirements, problems related to the control of their conduct.
A cognitive intervention program for reduction of stress in parents of children with intellectual and multiple disabilities: the effect on behavior problems and program adaptation through COVID-19 pandemic
Authors: Tiba Alexandru , Morar Cezar
Published: August 2022

Much evidence suggests that parents of children with special needs have elevated levels of stress when confronting with children’s problems. This article presents a validation of a multimodal cognitive program for reducing parental stress in parents and children behavior problems of children with special needs that can be applied during COVID-19 pandemic. A study including 63 parents of children with special needs shows that the program is effective both in reducing parental stress and children’s behavior problems reported by parents. Recommendations for the online use of the program and adaptations to the COVID-19 pandemic characteristics are made.
Challenges for Parents of Children with Disabilities during the COVID-19 Pandemic
Authors: Poptean Corina Bianca
Published: August 2022

Parents of children with disabilities are under more pressure than typical children. Moreover, the pandemic has brought additional challenges to those already in the families of children with special needs. The present study investigated what were the most important challenges these parents faced (emotional, educational, time management, financial, recovery-related challenges), but also the fact that they became teachers for children with SEN, or even took over certain responsibilities from therapists so as not to stagnate the recovery of their children. Many of them have experienced episodes of depression and anxiety.
A Focus on Waldenström Macroglobulinemia and AL Amyloidosis
Authors: Lu, MS, FNP Rebecca , Richards, PhD, ANP-BC, AOCNP Tiffany
Published: August 2022

Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma that is characterized by the overproduction of an IgM monoclonal protein. It may cause adenopathy, hepatomegaly, splenomegaly, as well as other disease-related complications such as cold agglutinin anemia, cryoglobulinemia, hyperviscosity, and neuropathy. While light chain amyloidosis in patients with WM only occurs in about 10% of patients, it is important that advanced practitioners are able to recognize concurrent AL amyloidosis, which will affect the patient’s treatment trajectory. Diagnosis of WM with AL amyloidosis is based on bone marrow biopsy and a fat pad biopsy. If AL amyloidosis is suspected, the bone marrow and fat pad biopsy should undergo Congo red staining. If it is negative, and there is a strong suspicion of AL amyloidosis, then an organ biopsy can be considered. Treatment of WM uses rituximab-based therapy in combination with a variety of other agents, including proteasome inhibitors, alkylating agents, and BTK inhibitors. Treatment of light chain amyloidosis uses bortezomib as the backbone of therapy and can be administered with cyclophosphamide, dexamethasone, and now daratumumab, which was recently approved. Waldenström macroglobulinemia and light chain amyloidosis are both rare diseases and can lead to a variety of disease-related complications. Fortunately, many options exist for both diseases. This article will highlight a case of WM with amyloidosis and a case of a patient with relapsing WM with considerations for advanced practitioners managing this patient population.
Improving Cancer Care Delivery: Learnings for Oncology Nurses and Patient Navigation From a National Quality Survey
Authors: Aversano, MSN, RN, OCN, BMTCN Jennifer , M. Boehmer, PharmD, BCOP Leigh , Spira, MD, PhD, FACP Alexander
Published: August 2022

Background: Although implementation of patient navigation programs in clinical practice is widespread, heterogeneity exists in the design and delivery of these services. Greater clarity is required on competencies of personnel, delineation of their roles in multidisciplinary cancer care teams, navigation service components that positively impact patient outcomes, and associated metrics. Methods: A national, double-blind, online survey was implemented between January 24, 2019, and April 25, 2019, to investigate care coordination for advanced (stage III/IV) non–small cell lung cancer (NSCLC). Respondents included multidisciplinary team (MDT) members, such as oncologists, pathologists, oncology nurses, advanced practice nurses, and patient navigators, from US cancer programs. Customized questions covered NSCLC screening, diagnosis, treatment, and care coordination, with a focus on oncology nurses, advanced practice nurses, and patient navigation. Descriptive statistics were computed. Subanalyses examined relationships between care delivery and outcomes such as shared decision-making (SDM) through statistical testing. Results: Across programs, there was a lack of patient (nurse or lay) navigators (22.3%, 101/452) to assist patients with NSCLC. Most respondents (90.1%, 100/111) worked in programs with no formal health literacy assessments. Significantly higher mean SDM scores (p < .05) were observed in programs with patient navigators compared with programs without these specialists. Conclusion: Patient navigation is pivotal to enhancing the patient experience along the lung cancer care continuum and should be strategically integrated within lung cancer MDTs. These findings, along with survey inputs from other MDT disciplines, can help support process improvement plans for patient-centered advanced NSCLC care delivery.
Measuring Advanced Practice Provider Productivity at the National Comprehensive Cancer Network’s Member Institutions
Authors: Krause, MHA Diana , Sharrah, DNP, APRN, FNP-C Karen , Gross, PhD, RN Anne , Bowers, PA-C Danielle , Mulkerin, MD Daniel , Brandt, APNP Nancy , Kennedy, MSN, RN Kate , Austin, MSN, AGACNP, AOCNP Annie , Begue, NP Aaron , Bell, NP, PhD Rose , Raczyk, PA Cheryl , Pickard, MMSc, PA-C, DFAAPA Todd , Kubal, MD, MBA Timothy , Johnson, PA-C Dave , Jeffries, CNP Kellyann , Dest, MSN, APRN, BC, AOCN Vanna , Randall, MSN, APRN-CNP, AOCNP Rory , Sugalski, MPPA Jessica , Zecha, PA-C, MHA Gabrielle
Published: August 2022

Introduction: The utilization of advanced practice providers (APPs) in oncology has been growing over the last decade; however, there is no standard method for assessing an APP’s contributions to oncology care. Methods: The NCCN Best Practices Committee (BPC) created an APP Workgroup to develop recommendations to support the roles of APPs at NCCN Member Institutions. The Workgroup conducted surveys to understand how NCCN centers measure productivity. This article will review the survey results and provide recommendations for measuring APP productivity. Results: Although 54% of responding centers indicated they utilize relative value units (RVU) targets for independent APP visits, 88% of APPs are either unsure or do not believe RVUs are an effective measurement of overall productivity. Relative value units do not reflect non-billable hours, and APPs perform a significant number of non-billable tasks that are important to oncology practices. Sixty-six percent of APPs believe that measuring disease-based team productivity is a more reasonable assessment of APP productivity than measuring productivity at the individual level. Conclusion: Our recommendation for cancer centers is to focus on the value that APPs provide to overall care delivery. Advanced practice provider productivity metrics should consider not only the number of patients seen by APPs, but also the high quality and thorough care delivered that contributes to the overall care of the patient and practice. Advanced practice providers can help improve access to care, deliver improved outcomes, and increase patient and provider satisfaction. Reducing the focus on RVUs, accounting for important non-RVU–generating activities, and incorporating quality and team metrics will provide a better overall picture of APP productivity.
An Approach to Diagnosis of Richter Transformation in Chronic Lymphocytic Leukemia
Authors: Broadway-Duren, PhD, DNP, APRN, FNP-BC Jackie
Published: August 2022

Richter transformation (RT) is the development of high-grade lymphoma in patients with B-cell chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). CLL/SLL is a heterogenous disease with a highly variable clinical course. Disease progression in patients with CLL continues to occur even in the era of novel therapies. A small percentage of CLL patients will develop aggressive histologic transformation to diffuse large B-cell lymphoma (DLBCL), commonly known as RT. It is known that certain genetic aberrations predispose patients to RT, including mutations in NOTCH1, TP53, CDKN2A, and unmutated IGHV somatic mutations. Historically, challenges existed in making a definitive diagnosis of RT. More recently, clonal relationships between the underlying CLL and DLBCL-RT are primarily diagnosed by sequencing immunoglobulin genes. Yet, RT continues to present challenges to health-care providers in managing patients with CLL/SLL, even with novel agents. This article aims to increase advanced practitioner awareness of predictive factors for RT, clinical manifestations, and diagnostic criteria to promote early recognition and intervention. Advanced practitioners need to be cognizant of clinical signs of RT and of diagnostic criteria for an appropriate and rapid diagnosis. In doing so, the advanced practitioner can promote early diagnosis and intervention, which may improve patient outcomes, given the dismal prognosis of RT.
Guide to Secure Enterprise Network Access Landscape
Authors: Chandramouli Ramaswamy
Published: August 2022

Access to multiple cloud services, the geographic spread of enterprise IT resources (including multiple data centers), and the emergence of microservices-based applications (as opposed to monolithic ones) have significantly altered the enterprise network landscape. This document is meant to provide guidance to this new enterprise network landscape from a secure operations perspective. Hence, it starts by examining the security limitations of the current network access solutions to the enterprise network. It then considers security feature enhancements to traditional network appliances in the form of point security solutions, network configurations for various security functions (e.g., application security, cloud access security, device or endpoint security, etc.), security frameworks that integrate these individual network configurations, and the evolving wide area network (WAN) infrastructure to provide a comprehensive set of security services for the modern enterprise network landscape.
Study on particle generation model of anode in rod-pinch diode
Authors: Qu Jun-Fu , Feng Yuan-Wei , Geng Li-Dong , Li Hong-Tao ,   Institute of Fluid Physics, CAEP, Mianyang 621900, China,   Graduate School of China Academy of Engineering Physics, Mianyang 621999, China
Published: August 2022

Flash radiography technology is commonly used in detonation physics experiments and nondestructive testing, in which an X-ray diode is an integral part of flash radiography equipment. Its function is to convert the electric energy stored in the front power supply into X-rays through the bremsstrahlung effect. Rod-pinch diode is one of the most commonly used X-ray diodes in 1–4 MV. It has the characteristics of a small focal spot and high imaging resolution. The anode ions of the rod pinch diode come from the anode plasma, and the anode plasma electrons are generated at the same time as the anode plasma ions. Before the establishment of the bipolar current between the anode and cathode of the rod pinch diode, these electrons are mainly absorbed by the anode; however, after the formation of the bipolar current, due to the zero electric field on the anode surface, plasma electrons will accumulate near the anode surface and will not be absorbed. Given the theoretical derivation of bipolar current in the gap between anode and cathode of rod pinch diode in the early stage, it is necessary to study the electrons in anode plasma.

The simulation of the rod-pinch diode is an essential tool for improving the performance of the rod-pinch diode. To improve simulation accuracy, it is necessary to study the emission mechanism of cathode and anode particles and continuously optimize the simulation model. In this paper, PIC and Monte Carlo simulation are used. An anode plasma model is proposed in this work based on the anode ion emission model of the rod-pinch diode and the characteristics of space charge bipolar flow, that is, when the anode plasma environment is fully established, the electric field on the anode surface is zero, and ions and electrons will accumulate on the anode surface. The new model is analyzed in detail and compared with the anode ion emission model in rod-pinch diode current, electromagnetic field distribution between cathode and anode, electron energy spectrum, motion state of electron incident anode rod, dose, and spot size. The results show that the calculation results from the new model are closer to the experimental results, which shows that the role of electrons accumulated near the anode in the plasma cannot be ignored in the numerical calculation of the rod-pinch diode anode rod surface plasma.
On the derivatives of B-Tribonacci polynomials
Authors:   Department of Mathematics and Statistics, Dnyanprassarak Mandal’s College and Research Centre, Arolkar Suchita
Published: August 2022

In this paper, B-Tribonacci polynomials which are extensions of Fibonacci polynomials are defined. Some identities relating B-Tribonacci polynomials and their derivatives are established.
Average value of some certain types of arithmetic functions with Piatetski-Shapiro sequences
Authors:   Department of Mathematics, Faculty of Science, Naresuan University, Janphaisaeng Suphawan , Srichan Teerapat ,   Department of Mathematics, Faculty of Science, Kasetsart University, Tangsupphathawat Pinthira ,   Department of Mathematics, Faculty of Science and Technology, Phranakorn Rajabhat University
Published: August 2022

In this paper, we study asymptotic behaviour of the sum $\sum_{n\leq N}{f}\Big(\lfloor n^c \rfloor\Big),$ where $f(n)=\sum_{d^2\mid n}g(d)$ under three different types of assumptions on $g$ and $1& < c < 2$.
The evolution of a counter-defense mechanism in a virus constrains its host range
Authors: Srikant Sriram , Guegler Chantal K , Laub Michael T
Published: August 2022

Bacteria use diverse immunity mechanisms to defend themselves against their viral predators, bacteriophages. In turn, phages can acquire counter-defense systems, but it remains unclear how such mechanisms arise and what factors constrain viral evolution. Here, we experimentally evolved T4 phage to overcome a phage-defensive toxin-antitoxin system, toxIN, in Escherichia coli. Through recombination, T4 rapidly acquires segmental amplifications of a previously uncharacterized gene, now named tifA, encoding an inhibitor of the toxin, ToxN. These amplifications subsequently drive large deletions elsewhere in T4’s genome to maintain a genome size compatible with capsid packaging. The deleted regions include accessory genes that help T4 overcome defense systems in alternative hosts. Thus, our results reveal a trade-off in viral evolution; the emergence of one counter-defense mechanism can lead to loss of other such mechanisms, thereby constraining host range. We propose that the accessory genomes of viruses reflect the integrated evolutionary history of the hosts they infected.
Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition
Authors: Li Yitong , Balakrishnan Vijaya Kumar , Rowse Michael , Wu Cheng-Guo , Bravos Anastasia Phoebe , Yadav Vikash K , Ivarsson Ylva , Strack Stefan , Novikova Irina V , Xing Yongna
Published: August 2022

Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes methylesterase activation upon binding to the PP2A core enzyme. Here, we showed that PME-1 readily demethylates different families of PP2A holoenzymes and blocks substrate recognition in vitro. The high-resolution cryoelectron microscopy structure of a PP2A-B56 holoenzyme–PME-1 complex reveals that PME-1 disordered regions, including a substrate-mimicking motif, tether to the B56 regulatory subunit at remote sites. They occupy the holoenzyme substrate-binding groove and allow large structural shifts in both holoenzyme and PME-1 to enable multipartite contacts at structured cores to activate the methylesterase. B56 interface mutations selectively block PME-1 activity toward PP2A-B56 holoenzymes and affect the methylation of a fraction of total cellular PP2A. The B56 interface mutations allow us to uncover B56-specific PME-1 functions in p53 signaling. Our studies reveal multiple mechanisms of PME-1 in suppressing holoenzyme functions and versatile PME-1 activities derived from coupling substrate-mimicking motifs to dynamic structured cores.
Modular, cascade-like transcriptional program of regeneration in Stentor
Authors: Sood Pranidhi , Lin Athena , Yan Connie , McGillivary Rebecca , Diaz Ulises , Makushok Tatyana , Nadkarni Ambika V , Tang Sindy KY , Marshall Wallace F
Published: August 2022

The giant ciliate Stentor coeruleus is a classical model system for studying regeneration and morphogenesis in a single cell. The anterior of the cell is marked by an array of cilia, known as the oral apparatus, which can be induced to shed and regenerate in a series of reproducible morphological steps, previously shown to require transcription. If a cell is cut in half, each half regenerates an intact cell. We used RNA sequencing (RNAseq) to assay the dynamic changes in Stentor’s transcriptome during regeneration, after both oral apparatus shedding and bisection, allowing us to identify distinct temporal waves of gene expression including kinases, RNA -binding proteins, centriole biogenesis factors, and orthologs of human ciliopathy genes. By comparing transcriptional profiles of different regeneration events, we identified distinct modules of gene expression corresponding to oral apparatus regeneration, posterior holdfast regeneration, and recovery after wounding. By measuring gene expression after blocking translation, we show that the sequential waves of gene expression involve a cascade mechanism in which later waves of expression are triggered by translation products of early-expressed genes. Among the early-expressed genes, we identified an E2F transcription factor and the RNA-binding protein Pumilio as potential regulators of regeneration based on the expression pattern of their predicted target genes. RNAi-mediated knockdown experiments indicate that Pumilio is required for regenerating oral structures of the correct size. E2F is involved in the completion of regeneration but is dispensable for earlier steps. This work allows us to classify regeneration genes into groups based on their potential role for regeneration in distinct cell regeneration paradigms, and provides insight into how a single cell can coordinate complex morphogenetic pathways to regenerate missing structures.
Institutional Work in a Palliative Unit: “There is Less Time for Patient Contact”
Authors: Mæhre Kjersti Sunde , Solstad Elsa
Published: August 2022

The encounter between divergent institutional logics may be challenging for nurses, since they must balance different expectations in their daily institutional work. These challenges increase when new reforms are introduced. Our research question is: How do actors linked to a palliative care unit experience the consequences of the Coordination reform in their daily performance of care work? Our study is based on a qualitative study in a palliative care unit in a nursing home where we interviewed patients, their relatives, and nurses/department leaders. Our findings show that by downgrading the professional logic because of the Coordination reform, the focus is on efficiency and budget instead of proper healthcare. This is not satisfactory for any of the actors in our study. We contribute to the research on the reforming of the healthcare sector by focusing on how different actors experienced day-to-day activities in a context where different institutional logics were involved.
In silicotesting of flavonoids as potential inhibitors of protease and helicase domains of dengue and Zika viruses
Authors: Cruz-Arreola Omar , Orduña-Diaz Abdu , Domínguez Fabiola , Reyes-Leyva Julio , Vallejo-Ruiz Verónica , Domínguez-Ramírez Lenin , Santos-López Gerardo
Published: August 2022

Background

Dengue and Zika are two major vector-borne diseases. Dengue causes up to 25,000 deaths and nearly a 100 million cases worldwide per year, while the incidence of Zika has increased in recent years. Although Zika has been associated to fetal microcephaly and Guillain-Barré syndrome both it and dengue have common clinical symptoms such as severe headache, retroocular pain, muscle and join pain, nausea, vomiting, and rash. Currently, vaccines have been designed and antivirals have been identified for these diseases but there still need for more options for treatment. Our group previously obtained some fractions from medicinal plants that blocked dengue virus (DENV) infectionin vitro. In the present work, we explored the possible targets by molecular docking a group of molecules contained in the plant fractions against DENV and Zika virus (ZIKV) NS3-helicase (NS3-hel) and NS3-protease (NS3-pro) structures. Finally, the best ligands were evaluated by molecular dynamic simulations.

Methods

To establish if these molecules could act as wide spectrum inhibitors, we used structures from four DENV serotypes and from ZIKV. ADFR 1.2 rc1 software was used for docking analysis; subsequently molecular dynamics analysis was carried out using AMBER20.

Results

Docking suggested that 3,5-dicaffeoylquinic acid (DCA01), quercetin 3-rutinoside (QNR05) and quercetin 3,7-diglucoside (QND10) can tightly bind to both NS3-hel and NS3-pro. However, after a molecular dynamics analysis, tight binding was not maintained for NS3-hel. In contrast, NS3-pro from two dengue serotypes, DENV3 and DENV4, retained both QNR05 and QND10 which converged near the catalytic site. After the molecular dynamics analysis, both ligands presented a stable trajectory over time, in contrast to DCA01. These findings allowed us to work on the design of a molecule called MOD10, using the QND10 skeleton to improve the interaction in the active site of the NS3-pro domain, which was verified through molecular dynamics simulation, turning out to be better than QNR05 and QND10, both in interaction and in the trajectory.

Discussion

Our results suggests that NS3-hel RNA empty binding site is not a good target for drug design as the binding site located through docking is too big. However, our results indicate that QNR05 and QND10 could block NS3-pro activity in DENV and ZIKV. In the interaction with these molecules, the sub-pocket-2 remained unoccupied in NS3-pro, leaving opportunity for improvement and drug design using the quercetin scaffold. The analysis of the NS3-pro in complex with MOD10 show a molecule that exerts contact with sub-pockets S1, S1’, S2 and S3, increasing its affinity and apparent stability on NS3-pro.
Marketing of BT Cotton in Different Marketing Channels in Manchirial District, Telangana
Authors: Aditya Kamera , Kumar Sanjay
Published: August 2022

The present study was conducted in Manchirial district of Telangana. Being the leading BT cotton producer in the country, cotton production in Telangana has many problems and constraints. The major problems faced by the cotton farmers were changing weather conditions, price fluctuations. There’s also been a labour scarcity, transportation and lack of preservation techniques which make the farmer to sell cotton at low cost. From Out of total blocks of Manchirial district one block has been selected purposely on the basis having high total area, production of BT Cotton for current study. Farmers growing BT Cotton is collected from Village Agriculture Assistant (VAA) and selected among them randomly. Highest quantity of produce was sold through channel I and comparably lowest quantity of produce was sold through channel III and channel II. Producer share in consumer price was highest in channel III i.e., 84.97% compared to channel I i.e., 84.64% and lowest in channel II i.e., 83.85%. Price spread was highest in channel I i.e., RS 1168/qtl compared to channel II i.e., RS 1037/qtl and channel III i.e., 1010. Marketing efficiency was highest in channel III i.e., 6.65% compared to channel II i.e., 6.19%% and channel III i.e., 6.51%.
The Cointegrating Analysis of Edible Sunflower Oil Trade in India
Authors: Rath Bidisha , Selvaraj K. N. , Parimalrangan R. , Ravikumar R.
Published: August 2022

The present study aimed at using the co-integration analysis, to find out, if or not, there exists a long run relationship amongst the consumption of sunflower oil and the tariff rates, imports, production and domestic prices in India. The co-integration analysis was also used to confirm if there exists market integration for edible sunflower oil for domestic and international markets. Annual time series secondary data was collected for tariff rates, consumption, from various sources for this study. The test was carried out using E-Views software. The results indicate strong long run relationship of consumption of edible sunflower oil with all the independent variables taken into consideration as three cointegrating equations were obtained. Only one cointegration equation was obtained when international prices and domestic prices were subjected to this test, indicating a relationship amongst the domestic and international markets and suggesting the presence of market integration.
What Principle Governs the Chemical Dynamic/Kinetic Process (2)?
Authors: Xu Wei-Xing
Published: August 2022

In this work we explored the detail relation between the positive and reverse chemical reaction rates. It is found that the differential relation between the positive and reverse chemical reaction rates is not simple counter relation. Furthermore, it is revealed that the dynamic/kinetic process automatically broke the symmetry of the nature and during the differential process, the positive and reverse chemical reactions allow duplication. The detail odd-even principle has been elucidated in this work.
Socio-Demographic Variables of People Living with HIV/AIDS Initiated on ART in 2014 at Tertiary Health Institution in Enugu State
Authors: Igwe Matthew Chibunna , Obeagu Emmanuel Ifeanyi , Ogbuabor Alphonsus Ogbonna , Eze Gloria Chizoba , Ikpenwa Justina N. , Eze-Steven P. E.
Published: August 2022

Background Information: Survival of people living with HIV/AIDS (PLWHA) has increased since the emergency of High active antiretroviral therapy (HAART) in 1996.

Methodology: This was a descriptive cross-sectional study design. The study population consisted of those diagnosed for HIV / AIDS at tertiary health institutions in Enugu State. The total numbers of clients enrolled were 793 and 249 clients were loss to follow up, majority was males. Those initiated on ART were 544. Clients of age <15 years were excluded and they were 31 clients. Finally, 500 clients were selected, males were 138 and female were 362 by simple random sampling techniques. Data was collected from HIV / AIDS patients ART record cards, registers and institutions data units for those initiated on ART in 2014 using a designed proforma. Those clients aged 15 years and above were retrospectively studied between 2014 and 2018 and some of them that survived after five years (60 months) on ART were interviewed by applying simple random sampling technique. Cohort inclusion begins at initiation on ART with follow-up clinical information collected year by year for five years. IBM SPSS statistics version 24.0 was used. Chi square test was used to assess association between categorical variables and the level of statistical significance of the proportions was determined by a P-value less than 0.05. Manual content analysis was used for the interview and probability of dying and surviving analysis.

Results: The mean age (±SD) is 38.8±11.5 years. On outcome of ART, 374 (74.8%) were under care, those loss to follow up were 66 (13.2 %), 29 (5.8%) died within the period of study and 31 (6.2%) were transferred out. Adherence was statistically significant, p<0.001 among clients who had obtained tertiary 105 (92.1%) and secondary, 124 (57.7%) education, who lived within the state with the place of care, 234 (76.0%), and those retired, 12 (63.2%) and the unemployed, 46 (61.3%).

Conclusion: Based on the study, HIV prevalence in Nigeria now appears to have assumed a downward trend following the availability of ART and a relative stability from 2012 to 2018, yet a sustained and more effective intervention is still needed to avert increase incidence by most-at–risk subpopulations in the Enugu State.
Comparative Economics of Traditional and Modern Dairy Farms in Eastern U.P.
Authors: Yadav Bhartendu , Kumar Birendra , Singh Pavan Kumar , Tomar Gaurav , Choudhri H. P. Singh
Published: August 2022

A samples of total 270 dairy respondents were selected from the selected district and purposive cum random sampling technique was adopted for the study. It was observed that over all the categories of sample farm groups selected, the gross total investment was found in decreasing trend at Rs. /Animal i.e., Rs. 1660335.42, Rs. 176674.52 and Rs. 122801.01 for marginal, medium and large category of dairy farms, respectively. Overall Net returns per litre of milk produced were found Rs. 12 on traditional farm and Rs. 12.73 on modern farm. In the similar trend, the overall per day returns from traditional and modern dairy farms was found Rs. 241.09 and Rs. 262.56, respectively. Overall study reveals that enhanced income can be enjoyed by adopting modern approach of dairy farming.
Studies of Phytochemicals and In vitro Radical Scavenging Potentials of Six Different Wild Fruits Consumed in South-Eastern Nigeria
Authors: Maduako Maryann Chinenye , Amaefule Kizito Ifeanyi , Ifemeje Jonathan Chinenye
Published: August 2022

Objective: The study was carried out in order to document the phytochemical contents and radical scavenging capacities of different wild fruits consumed in south eastern Nigeria.

Methods: Phytochemical screening and in-vitro antioxidant studies were carried out using standard method.

Result: The results of quantitative phytochemical screening indicated the presence of flavonoids, tannins, phenols, terpenoids, alkaloids, saponins, steroids, oxalate and cardiac glycosides in varying concentrations. The in vitro antioxidant study showed that African elemi and African velvet tamarind with EC50 1.68 ± 0.03 and 1.81 ± 0.01 µg/ml respectively scavenged DPPH radical more than other extracts compared to ascorbic acid EC50 1.25 ± 0.02 while wild mango (EC50 0.98 ± 0.01 μg/ml), pepper fruits (EC50 1.75 ± 0.02 μg/ml) and date fruit (EC50 1.88 ± 0.01 μg/ml) scavenged hydroxyl radical more than other extracts used in this study. All the extract showed a concentration dependency in reducing ferric iron to ferrous ion, also date fruit (0.11 ± 0.00 μg/ml) had more of the total antioxidant compounds in this study compared to ascorbic acid (0.22 ± 0.01μg/ml).

Conclusion: The high quantity of phytochemicals and radical scavenging capacity of the wild fruits shows their importance in nutrition; therefore wild fruits should be included in our daily diet to improve the quality and nutritional values of food.
Influence of Different Doses and Methods of Phosphorous Solubilizing Bacteria and Phosphorus Levels on the Phosphorus Solubilizing Bacteria Population and Phosphorous Use Efficiency in Sunflower and Chickpea
Authors: Chandana Mudigiri , Qureshi A. Aziz , Sharma S. Harish kumar , Triveni S.
Published: August 2022

A field experiment was conducted to study The effect of the application method and different doses of phosphate solubilizing bacteria (PSB) application and the phosphorus levels on sunflower during Rabi, 2020 at College of Agriculture, PJTSAU, Rajendranagar, Hyderabad. The experiment was laid out in Randomized Block Design, comprising eleven treatments with three replications. Initial soil parameters of experimental site indicated that the soil belongs to sandy loam texture, with alkaline in soil reaction, non-saline, low in O.C, low in available nitrogen, medium in available phosphorus, available potassium and available sulphur. The results showed that due to addition of PSB in powdered and liquid form there was an increase in PSB population in the soil, the increase in population is with the application of 75% phosphorus + PSB at 6 kg/ha in both crops. The increase in population is more with the soil application than the Drenching. Due to this there is also an increase in the phosphorous use efficiency. The above study indicated that combined application of PSB with reduced P levels could help in saving fertilizer dose to the extent of 25% in sunflower and 50% in chickpea.
Traits Associated with Drought Tolerance in Tomato (Solanum lycopersicum L.)
Authors: Kousalya Kodipelli , Sankari A. , Pugalendhi L. , Djanaguiraman M.
Published: August 2022

Across the globe, tomato (Solanum lycopersicum L.) is a commonly used vegetable for culinary purposes. Despite its economic importance, its production is decreasing now a days due to the occurrence of various abiotic stresses like drought. Hence, it is important to understand the mechanism of drought tolerance to sustain tomato production. A field experiment was conducted with drought tolerant and susceptible genotypes to understand the mechanism of tolerance or susceptibility. Drought stress was imposed during the flowering stage for 19 days. The physiological traits like relative water content, pigmentation, flower abscission percentage and fruit set percentage were recorded. The results showed that relative water content was decreased by 20.47 % in the SL CBE G 26 and 40.98 % in the SL CBE G 23. However, the flower drop was highest in the line SL CBE G 23 (23.29%) and lowest in SL CBE G 26 (19.14 %) under drought stress. The line SL CBE G 23 had lower fruit set than SL CBE 26. Hence, the study confirmed that SL CBE G 26 is a drought tolerant line and drought tolerance is associated with increased water retention in the tissue, eventually resulting in decreased flower drop and increased fruit set percentage.
Performance of Turmeric (Curcuma longa L.) Genotypes on Growth and Yield under Prayagraj Agro-Climatic Zone
Authors: Annie S. L. , Singh Devi , Umesha C.
Published: August 2022

An experiment was conducted on the Performance of turmeric (Curcuma longa L.)  genotypes on growth and yield under Prayagraj agro-climatic zone at Research Field, Department of Horticulture, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, during April 2021 to February 2022. Fifteen genotypes including check variety were evaluated to ascertain the performance of genotypes under Prayagraj agro-climatic conditions. The experiment was laid out with 15 genotypes replicated thrice in Randomized Block Design. The result of the present investigation, regarding the performance of 15 genotypes Alleppey supreme, Kandi, Kedaram, Lakadong, Megha-1, Prabha, Pragati, Prathibha, Soba, Sona, Sudharsana, Suguna, Suvarna, Varna and UP Local from different sources evaluated for plant growth and yield.   The present investigation concluded that the genotype Pragati, performed well in plant growth and yield followed by Sona, and Prabha. In terms of economics, the maximum Cost Benefit ratio (4.78) was recorded in Pragati. Overall results revealed that Pragati was suitable for growing under Prayagraj agro-climatic conditions.
Effects of GA3 and NAA on Growth and Yield of Brinjal (Solanum melongena L.) cv. Kashi Sandesh
Authors: Patel Sudheer Kumar , Verma Shivaraj Kumar , Maurya Brijesh Kumar , Maurya Shravan Kumar , Patel Yogesh Chandra , Prakash Shyam
Published: August 2022

A field experiment was conducted to find out the Effect of two concentrations of GA3 and NAA and their combinations on growth and yield of brinjal (Solanum melongena L.) cv. Kashi Sandesh. The experiment was laid out in Randomized Block Design with three replications and nine treatments. Higher growth attributing characters viz. maximum plant height (71.14 cm), number of leaves per plant (71.65), number of branches (12.77), Days to 50% flowering (43.12) and yield & yield attributing characters, viz,. number of fruit per plant (16.17), fruit length (11.66 cm), fruit weight (180.48 g), fruit diameter (9.48 cm), fruit yield (2.91 kg/plant), fruit yield (29.22 kg/plot), fruit yield (383.95 q/ha) were recorded under T8- NAA + GA3 (40 ppm + 50 ppm). Similarly, maximum net return (421750.86 Rs/ha) and B:C ratio (2.73) were recorded under T8- NAA + GA3 (40 ppm + 50 ppm) followed by treatment T7- and T6. T9- Control was produced poor performance among all the treatments.
‘Spread’ of Artemisinin Resistance in Myanmar Revisited
Authors: Grist Eric P. M.
Published: August 2022

Geostatistical models have been widely used to represent disease prevalence in spatial disease mapping. More recently, these models have been employed to estimate geographic ‘spread’ of artemisinin resistance (AR) in South East Asia from genetic mutations identified in the K13 gene of the malaria Plasmodiumfalciparum parasite. Here, I revisit the question of ‘spread’ of AR as represented by resistant plasmodiumfalciparum in Myanmar, when re-evaluated from K13 mutant alleles data published by Tun et al. [1]. The new analysis gives a broader perspective by incorporating information published by the World Health Organization (WHO) in 2015 and subsequently in 2018 of the K13 mutant alleles confirmed to confer or to be associated with artemisinin resistance. This provides insights which hitherto have not been described and reveals the disparity between the estimation of ‘spread’ of AR by Tun et al. [1] and that of AR prevalence based on metrics which are supported by published WHO data.