bluuebunny/crossref_metadata_2025 huggingface dataset:
KRITIK SOSIAL DAN NILAI PENDIDIKAN KARAKTER DALAM NASKAH DRAMA THE DUKUN DAN RELEVANSINYA DENGAN PEMBELAJARAN SASTRA DI SEKOLAH MENENGAH ATAS
Authors: Nugroho Wahid Ibnu , Suwandi Sarwiji , Hastuti Sri
Published: January 2022

This research aims to describe social criticism; the value of character building in drama script “the dukun” by Dukut Wahyu Nugroho, and the relevance of drama script “the dukun” by Dukut Wahyu Nugroho as literary teaching material in the senior high school. The sampling technique used is purposive for the sample is chosen based on certain purpose in order to reach the objective of this research. The source of data is drama script “the dukun” by dukut wahyu nugroho and informant, therefore the data are collected by document review and interview. The test validity of the research data used triangulation of theory and triangulation of source. The analysis of data was done by interactive analysis which is consisting of data collection, data reduction, data presentation, and conclusion. The result of this research describes that the drama script “the dukun” besides has a simple plot and can be shown in senior high school learning, also gives a deep moral message to the reader. Story plotting that coherent can be used as a research object to add insight of the literature sociology, so can be implemented in learning Bahasa Indonesia in senior high school and keep mind to the SK/KD which is used.
ANALISIS KELAYAKAN BUKU TEKS BAHASA INDONESIA MAHIR BERBAHASA INDONESIA (MARBI) KELAS VII EDISI REVISI
Authors: Nur Alviya Siti Risna , Mulyaningsih Indrya , Khuzaemah Emah
Published: January 2022

This study aims to determine the feasibility of the revised edition of the revised edition of the Indonesian Advanced Bahasa Indonesia (MARBI) textbook. The assessment of the feasibility of a textbook is based on BSNP standards by analyzing four feasibility including content feasibility, linguistic feasibility, presentation feasibility, and graphic feasibility. This research is included in descriptive qualitative research. The data source of this research is the opinion of the Indonesian language teacher who has used the textbook and the revised edition of the MARBI textbook for grade VII. The data in this study are textual units and non-textual units. Data collection techniques with document analysis, interviews, and fry charts. The data collection instruments used were assessment sheets based on the BSNP, interview guidelines, and fry charts. The validity of the data in this study was obtained from the triangulation of data sources, triangulation of theories, and triangulation of data collection methods. Data analysis was performed interactively with data reduction procedures, data presentation, and drawing conclusions / verification. The results of the feasibility analysis of the MARBI textbook were the content / material feasibility with a value of 76.62%; 2) linguistic feasibility with a value of 82.85%; 3) the feasibility of serving with a value of 83.33%; and 4) the feasibility of the graphics with a value of 82.61%. This feasibility still needs guidance from educators.
ANALISIS TOKOH UTAMA DAN NILAI PENDIDIKAN KARAKTER DALAM NOVEL PADA SEBUAH KAPAL KARYA N.H. DINI SERTA RELEVANSINYA SEBAGAI BAHAN AJAR DI SMA
Authors: Chriszia Deyana , Suyitno Suyitno , Suryanto Edy
Published: January 2022

This research intends to describe and explain: (1) Intrinsic elements of the novel of Pada Sebuah Kapal by N. H. Dini; (2) The character building elements of the main role of the novel of Pada Sebuah Kapal by N. H. Dini; (3) The character education values in the novel of Pada Sebuah Kapal by N. H. Dini; and (4) The result of the study of the novel of Pada Sebuah Kapal by N. H. Dini for teaching literature of XII Grade of senior high school students based on Basic Competencies 3.9, that is the analysis of context and linguistic of the novel. This research is descriptive qualitative research with the psychology literature study. The sample was collected by purposive sampling method. The data were collected by interview and document analysis. The data validity test that was used is the triangulation of data sources and member check or informant review. The data was analysed by flows analysis models method. The research results are: (1) Intrinsic elements that consist of theme, character and characterization, setting, plot, and point of view is interconnected and build each other in the process of the creation of literature. Through the analysis of intrinsic elements of the novel, the reader will be easier to understand the context of the read novel; (2) The character building elements of Sri as the main role consists of id, ego, and superego. Ego element is the dominant element because it affects the most of the decision making for the main role lives; (3) The character education values in the novel of Pada Sebuah Kapal by N. H. Dini consist of discipline, work hard, curiosity, nationality spirit, appreciating achievement, friendly/communicative, love to read, and responsibility. The responsibility value is the dominant value because it appears the most in the entire novel and able to affect other character education values; (4) The novel of Pada Sebuah Kapal by N. H. Dini can be used for teaching literature of XII Grade of senior high school students based on Basic Competencies 3.9, that is the analysis of context and linguistic of the novel. This novel also contains the character education values that able to strengthen students’ character that able to be a consideration in determining the good or bad values in daily life.
GAYA BAHASA DAN NILAI MORAL DALAM KUMPULAN PUISI "AYAT-AYAT API" KARYA SAPARDI DJOKO DAMONO SEBAGAI BAHAN AJAR SASTRA DI SMA
Authors: Saputri Iin Indah , Suhita Raheni , Mulyono Slamet
Published: January 2022

Penelitian ini bertujuan untuk mendeskripsikan (1) jenis gaya bahasa; (2) jenis nilai moral; dan (3) relevansi hasil temuan kumpulan puisi Ayat-Ayat Api karya Sapardi Djoko Damono sebagai bahan ajar sastra di sekolah menengah atas.  Jenis penelitian ini merupakan penelitian kualitatif dengan menggunakan pendeketan stilistika. Sumber data penelitian yang dilakukan ini adalah dokumen jenis gaya bahasa dan nilai moral dalam kumpulan puisi Ayat-Ayat Api karya Sapardi Djoko Damono, serta informan. Teknik pengumpulan data yang digunakan yaitu wawancara dan analisis dokumen. Peneliti menggunakan triangulasi teori dan sumber data sebagai uji validitas data. Hasil penelitian sebagai berikut. Pertama, terdapat 123 jenis gaya bahasa yang meliputi 34 gaya bahasa personifikasi, 32 gaya bahasa aliterasi, 21 gaya bahasa metafora, dan 14 gaya bahasa hiperbola. Kedua, terdapat 26 bentuk nilai moral yang berupa 11 aspek nilai berkata jujur, 7 aspek berbuat benar, 7 aspek berani, dan 1 aspek berlaku adil. Ketiga, hasil temuan kumpulan puisi Ayat-Ayat Api karya Sapardi Djoko Damono ini relevan dan dapat digunakan sebagai bahan ajar sastra di SMA khususnya kelas X pada KD 3.17 tentang menganalisis unsur pembangun puisi.
PENGGUNAAN GOOGLE CLASSROOM DI KELAS VIRTUAL DALAM PEMBELAJARAN BAHASA INDONESIA PADA MASA PANDEMI COVID-19 DI SMA
Authors: Rahmawati Berlyana , Utami Haryanti Budhi , Sudiyana Benedictus , Rohadi Agus
Published: January 2022

Adanya pandemi covid-19 sejak akhir tahun 2019 berpengaruh terhadap proses pembelajaran, yaitu tidak memungkinkan diadakannya pembelajaran dengan sistem tatap muka di kelas. Sesuai kebijakan pemerintah, pembelajaran formal di sekolah harus dilaksanakan secara daring dan salah satu medianya adalah aplikasi google classroom. Wahana tersebut merupakan hal baru bagi siswa sehingga memungkinkan berbagai hambatan dalam penggunaannya. Penelitian ini bertujuan untuk mendeskripsikan implementasi google classroom sebagai pengembangan kelas virtual dalam pembelajaran bahasa Indonesia pada masa pandemi covid-19. Metode penelitian ini adalah kualitatif deskriptif dengan melalui observasi langsung di SMA Negeri 1 Polokarto, Kabupaten Sukoharjo. Hasil penelitian menunjukkan bahwa pemanfaatan aplikasi google classroom dalam pembelajaran sudah efektif. Aplikasi dapat dioperasikan guru dan siswa. Meskipun demikian, siswa masih membutuhkan bimbingan guru secara langsung atau tatap muka selain pembelajaran daring melalui google classroom.
KRITIK SOSIAL DALAM CERPEN "PELAJARAN MENGARANG" KARYA SENO GUMIRA AJIDARMA MELALUI PENDEKATAN SEMIOTIKA PIERCE
Authors: Sasmita Aprillia Ratna
Published: January 2022

Sebagai sebuah respon yang menginterpretasikan kepekaan pengarang terhadap berbagai fenomena di sekitarnya, karya sastra hadir dengan berbagai muatan kritik, nilai, dan norma. Cerpen Pelajaran Mengarang karya Seno Gumira Ajidarma merupakan salah satu karya sastra yang hadir dengan muatan nilai-nilai dan kritik sosial untuk merespons realitas kehidupan lain masyarakat marjinal ibukota. Tujuan penelitian ini adalah untuk mengetahui kritik sosial pada Cerpen Pelajaran Mengarang karya Seno Gumira Ajidarma dengan menggunakan pendekatan semiotika tanda Pierce pada objek trikotomi relasi (makna) berupa ikon, indeks, dan simbol. Penelitian ini menggunakan pendekatan deskriptif kualitatif dengan metode analisis isi (studi pustaka). Metode pengumpulan data pada penelitian ini meliputi kegiatan membaca, mengidentifikasi, mencatat, dan menafsirkan data dengan teknik analisis data deskriptif kualitatif berupa studi pustaka (analisis isi). Hasil penelitian yang diperoleh menunjukkan bahwa kritik sosial yang dihadirkan pengarang melalui Cerpen Pelajaran Mengarang, ditinjau dari pendekatan semiotika Pierce mengenai tanda, yaitu ikon, indeks, dan simbol. Kritik sosial yang ditemukan antara lain: (1) kesalahan paradigma masyarakat tentang perkotaan; (2) status sosial pada masyarakat yang termarjinalkan bukanlah menjadi prioritas penting; dan (3) lingkungan sosial memiliki berbagai dampak kehidupan individu tersebut melekat pada karakter, tingkah laku, konflik batin, bahkan satuan bahasa yang digunakan oleh tokoh-tokoh di dalam cerpen.
PENGUCAPAN TEKS BAHASA INDONESIA OLEH MAHASISWA FILIPINA: KAJIAN FONOLOGI
Authors: Susilo Catharina Dian Ikawati , Indira Dian
Published: January 2022

Sering dijumpai perubahan pengucapan fonem-fonem bahasa Indonesia oleh orang-orang asing. Penelitian ini bertujuan untuk mendeskripsikan pengucapan fonem pada pasangan kata yang memuat pasangan minimal fonem dan teks berbahasa Indonesia oleh mahasiswa asal Filipina. Penelitian dilakukan dengan metode kualitatif deskriptif dengan pendekatan analisis kontrastif. Data yang digunakan adalah korpus pengucapan pasangan kata dan pembacaan teks pendek dalam bahasa Indonesia. Metode yang digunakan adalah teknik simak libat cakap (SLC). Pada penelitian ini, analisis data difokuskan pada klasifikasi identitas fonem berdasarkan bagian-bagian alat bicara yang menghasilkannya. Hasil penelitian menunjukkan adanya perubahan pengucapan fonem konsonan /r/ /s/ /n/ /g/ dan /k/ diucapkan dengan tekanan nada yang kuat, perubahan pengucapan vokal /o/ yang juga diucapkan secara kuat pada posisi yang seharusnya diucapkan lemah, serta vokal /e/ tidak dibaca sebagai /e/ melainkan dengan /ɛ/. Selain itu, ditemukan adanya fenomena penambahan fonem serta metatesis gabungan fonem dalam satu kata.
NILAI TOLERANSI DALAM CERPEN-CERPEN TERBITAN KORAN REPUBLIKA DARING DAN RELEVANSINYA SEBAGAI MATERI AJAR SASTRA DI SMA
Authors: Rahayu Elvira , Muhtarom Imam , Mujtaba Sahlan
Published: January 2022

Cerpen adalah prosa fiksi yang dibangun melalui unsur instrinsik dan ekstrinsik. Penulisan ini bertujuan untuk (1) mendeskripsikan unsur intrinsik, (2) mendeskripsikan nilai toleransi dan (3) membuat relevansi materi ajar sastra. Sumber data penelitian ini adalah 104 judul cerpen yang terbit di koran Republika Daring 2019. Yang menjadi sampel adalah 10 cerpen. Metode yang digunakan adalah deskriptif kualitatif dengan pendekatan analisis isi. Hasil penelitian ini adalah sebagai berikut: (1) unsur intrinsik: alurnya mayoritas campuran, tokohnya meliputi protagonis dan antagonis, latarnya meliputi latar tempat, latar waktu dan latar sosial budaya, amanatnya ajakan berperilaku baik, bahasanya populer, sudut pandang didominasi orang ketiga, dan mayoritas bertema Pendidikan; (2) nilai toleransi antara lain: sikap saling menghargai perbedaan pendapat, perbedaan keyakinan, agama, kepercayaan, tidak memaksakan kehendak dan menghargai keputusan orang lain; (3) relevan sebagai materi ajar sastra di SMA.
SOCIOECONOMIC DETERMINANTS OF DISABILITY IN THE TRANS-BAIKAL TERRITORY
Authors:   Chita State Medical Academy, Chita, Senizhuk A.I. , Baranova M.Ju. ,   Head Bureau of Medical and Social Expertise of the Trans-Baikal Territory, Ministry of Labor of the Russian Federation, Chita, Karelova S.Ju. ,   Head Bureau of Medical and Social Expertise of the Trans-Baikal Territory, Ministry of Labor of the Russian Federation, Chita, Vazhaeva S.S. ,   Chita State Medical Academy, Chita, Mizjun N.O. ,   Chita State Medical Academy, Chita
Published: January 2022

Significance. Disability remains a pressing problem in the modern society and each country is developing its social and economic policy for persons with disabilities according to the level of its development. The scale and nature of disability have been changing over time and are influenced by demographic, social, and economic factors. Purpose. To assess disability indicators and identify the most significant socioeconomic factors affecting their dynamics. Material and methods. The study was carried out by processing data from the state statistical reports of the Ministry of Health of the Russian Federation for the period 2017-2020, calculating dynamic series indicators, and the Spearman correlation analysis method. Results. Disability indicators in the Trans-Baikal Territory are positive. They are mainly accounted for by malignant neoplasms and diseases of the circulatory system. The study has proved the relationship between the unemployment rate and primary disability among the working population and recurrent disability among the adult working population (direct strong relationship), income and the level of primary and recurrent disability among the working population (inverse strong relationship), dilapidated housing and the level of primary and recurrent adult disability (direct strong relationship), and the share of housing with heating and the level of primary and recurrent disability among the working population (reverse strong relationship). Conclusion. During the period under study, the level of disability decreased. The relationship between socioeconomic factors and disability indicators has been proven.
REGULATORY AND STAFFING PROBLEMS OF UROLOGICAL CARE PROVIDED TO ADULTS AND CHILDREN IN OUTPATIENT SETTINGS
Authors:   Research Institute of Healthcare Organization and Medical Management of the Moscow Healthcare Department, Kuraeva V.M. ,   Moscow, Russia, Menshikova L.I. ,   Northern State Medical University, Arkhangelsk, Russia, Rugol L.V. ,   Federal Research Institute for Health Organization and Informatics of the Ministry of Health of the Russian Federation; Moscow, Russia
Published: January 2022

Significance. The regulatory and staffing problems in urological care delivery to adults and children in outpatient settings, combined with the high social significance of diseases of the genitourinary system for the population of different age, potentially threaten successful implementation of the priorities of the state demographic policy. Purpose: to identify problems in regulation and staffing in urological care delivery to adults and children on the outpatient basis in the Russian Federation in 2015-2019. Material and methods. The study used data of the Fedral statistical observation Form No. 30 "Information about a medical organization" for the period 2015-2019. Statistical processing of the study materials was carried out by methods of descriptive statistics. Results. The analysis has identified contradictions in the orders of the Ministry of Health of the Russian Federation, which currently regulate staffing in urological care. The number of full-time and occupied positions of urologists in 2015-2019 decreased, which, coupled with the increased number of individuals, resulted in the increased number of urologists (+3.1%), increased level of staffing of individuals up to 62.9%. At the same time, the part-time coefficient among urologists remained high adding up to to 1.3. In 2015-2019, the number of full-time and occupied positions and individual pediatric urologists-andrologists increased, against the background of extremely low staffing level of individuals equalling to 26.7% in 2019 without any significant dynamics over a 5-year period. The function of the urologist position remained unchanged (4072 appointments per position in 20194 and 4181.3 in 2015), while the function of the pediatric urologist-andrologist position increased from 4215 appointments per position in 2015 to 5342 in 2019 (+ 26,7%). The integral staffing coefficient had a negative trend especially in relation to pediatric urologists-andrologists. Conclusions. The growth in the number of individual urologists and pediatric urologists-andrologists in 2015-2019 did not result in any significant changes in the staffing levels in the urological care delivery to adults and children on the outpatient basis. It is necessary to update the staffing standards, objectify statistical reporting and take urgent measures to bridge the shortage of doctors in outpatient settings. Scope of application. The study results can be used for timely updates of regulatory legal acts, staffing schedules of medical organizations in planning and implementing human resource programs aimed at eliminating personnel shortages and imbalances.
The Impact of Selective Survival on Sex Disparities in Stroke Incidence: Evaluating Bias using a Simulation Model
Authors: Lin Xiaolei , Li Leah
Published: January 2022

Background: Males tend to have higher stroke incidence than females. The difference attenuates (or even reverses) in late-life. Using a simulation study, we assessed how selective survival impacted on age attenuation of the male-female difference in stroke incidence.Methods: We simulated a birth cohort of 50,000 males and 50,000 females. The distributions of survival and first stroke incident were calibrated from published data. We generated an unobserved construct U (i.e. risk factors for incident stroke and/or survival) and considered four causal scenarios based on the sex-specific association between U and survival. To assess the bias under each scenario, we compared male–female difference in stroke incidence from 45 to 95y with pre-specified value (5 per 1000 person-year). Results: Under all causal scenarios, male-female difference in stroke incidence was close to pre-specified value from mid-adulthood but decreased (thus bias increased) at older ages. There was only a small increase in bias when U did not affect survival (Scenario A). When U had a direct effect on survival, the difference decreased (thus bias increased) rapidly, reversed from 95y when U affected survival with a similar magnitude for males and females (Scenario B: hazard ratio (HR)=1.5). The difference reversed earlier when the effect of U on survival was greater for males than females: at 85y (Scenario C: HR=1.5 vs 1.0) and 80y (Scenario D: HR=2.5 vs 1.5). Conclusions: Males had higher stroke incidence overall, but the male-female difference attenuated with age when there existed unobserved common risk factors for stroke and survival. The survivor bias was greater when their association with survival differed by sex.
Application of fish scale derivatives in ameliorating the phytotoxicity effects of multi-metal contaminated soil on paddy rice
Authors: maleki-Roudposhti sahar , Ghasemi-Fasaei Reza , Ronaghi Abdolmajid , Baghernejad Majid
Published: January 2022

Immobilization is an efficient method in the remediation of heavy metal-polluted soils. A greenhouse experiment is conducted to investigate the influence of fish scale powder, chitin, and chitosan on the growth and chemical composition of rice grown on a soil contaminated with Zn, Pb, Cd, and Ni. Results showed that the application of fish scale powder, chitin, and chitosan significantly increased root and shoot dry matter yield of rice, but decreased Pb phytoextraction efficiency. Further, the translocation factor of Ni decreased following the application of fish scale powder and chitosan. Application of fish scale powder decreased Ni, Cd, Zn, and Pb bioavailability in soil. The addition of chitosan reduced Ni and Pb concentration in rice shoots. Among different amendments, only the application of chitosan had a significant effect on the reduction of Zn content in rice root. Considering that the translocation factors were less than one in all treatments, it can be concluded that biostabilization of the studied metals has occurred. based on the obtained results fish scale derivatives including fish scale powder and chitosan play an important role in the removal of heavy metals due to having suitable functional groups. Therefore, it can be deduced that due to the economic feasibility, environmentally friendly, and high metal removal capability of chitosan and fish scale powder, these two amendments are highly recommendable to be applied in multi-metal polluted soils for increasing metals removal and hence decreasing their phytotoxicity.
A Convolution Neural Network Approach to Doppler Spectra Classification of 205 MHz Radar
Authors: Thampy Baazil P , S Shailesh , M.V. Judy , Kottayil Ajil
Published: January 2022

Wind profiler radars are capable of measuring three-dimensional wind profiles at various altitudes of the atmosphere, at very high temporal and spatial resolution. The Advanced Centre for Atmospheric Radar Research (ACARR), located at Cochin University of Science and Technology (CUSAT), operates the World’s first 205 MHz stratospheretroposphere wind profiler radar which provides three-dimensional wind profiles for an altitude range of 315 m to 20 km. During non-rainy condition, the radar Doppler power spectrum bears the signature of ambient air motion whereas during rainy conditions, it contains signatures of both ambient air motion and fall velocity of rain droplets. The classification of Doppler power spectra for rainy (Precipitation) and non-rainy (Clear) conditions is necessary as wind profile retrieval from the former needs careful separation of ambient air motion from fall velocity of droplets. A manual classification of the power spectrum is cumbersome, time-consuming, and therefore not practical due to the vast database. This work intends to automate Doppler power spectra classification using the deep learning Convolutional Neural Network (CNN). The proposed Convolutional Neural Network model gives a k-fold validation accuracy of 99.77 % and testing accuracy of 99.60% for power spectra classification. The performance of CNN is compared against other popular machine learning classifiers such as Support Vector Machine, Decision Tree, K Nearest Neighbour and Naive Bayes. The performance comparison results show that the proposed CNN outperforms other models in radar Doppler power spectra classification.
Role of the Microbiota-Metabolite Axis in the Rotenone Model of Early-Stage Parkinson's Disease
Authors: Yan Zhenzhen , Li Ruihua , Shi Wanying , Yao Lifen
Published: January 2022

Gastrointestinal symptoms are common in the early-stage Parkinson's disease (PD), but its potential pathogenesis remains unclear. Therefore, in the present study, we used the 16S ribosomal RNA gene sequencing and gas chromatography coupled with mass spectrometry-based metabolomics investigated the gut microbiome alterations and the serum amino acid levels in early-stage PD mice model induced with rotenone and vehicle-induced control mice. The results demonstrated that the microbial taxa at phylum, family and genus levels remarkably altered in rotenone-induced mice relative to vehicle-induced mice. The rotenone-induced mice had higher relative abundances of Flavobacteriaceae, Staphylococcaceae, and Prevotellaceae as well as lower relative abundances of Lachnospiraceae_UCG-001, Ruminiclostridium, and Prevotellaceae_NK3B31_group than vehicle-induced mice. The evaluation of serum amino acids revealed the alterations in several classes of amino acids, including L-proline, L-alanine, L-serine, L-asparagine, L-threonine, L-glutamine, L-methionine, and L-4-hydroxyproline. Notably, the altered serum amino acid levels were significantly associated with the abundance of gut microbiota, especially Ruminococcaceae and Ruminiclostridium. Our study explored the possible role of the gut-microbiota-metabolite axis in the early-stage PD and provided the possibility of prevention and treatment of PD by gut microbiota-metabolite axis in the future.
Impacts of the inclusion of folded geogrids on the load-settlement behavior of strip footing overlaid fine sand
Authors: Ahmad Hussein
Published: January 2022

This paper describes experimental studies on a strip footing overlaid with unreinforced, planar geogrid-reinforced, and folded geogrid layers of fine sand subjected to static loading. The footing settlement was determined for plate loading of over 25 kN. The variables are assessed in the testing program, including the number of planar geogrid layers, the position of the folded geogrid within the soil, the thickness of the geogrid folded layer, wraparound lap and overlap lengths of a folded geogrid, the spacing within geogrid folded layers, and several geogrid layers. The results indicated the superiority of footing performance as a result of static loading for geogrid folded reinforced sand compared to planar geogrid reinforced sand. In addition, a critical region was found at a certain depth under the footing, where a geogrid folded results in increased footing settlement. This critical area affects the behavior of sandy soils with low footing widths. As a result of static loading, the soil compacts within depth, and sand particles penetrate between the geogrid apertures. Then, they accumulate in a specific area inside the folded geogrid; therefore, they cause small gaps that lead to the rotation of the strip footing in the soil at the foundation surface. In total, based on the results, the reinforced soil-footing systems with adequate folding geogrid layers behave much stiffer; thus, they can handle higher loads with lower settlement than those in planar reinforced soil. Additionally, the results show that the embedment depth and thickness of the folded geogrid are 0.41 and 0.2 of the footing widths, respectively. Consequently, the settlement rate is significantly reduced by increasing the number of folded geogrid layers. The findings revealed that the wraparound technique solution for reinforced cases considerably improves the bearing capacity, reduces settlement, and uses in tight bed spaces.
Reproductive Outcomes of Patients with Septate Uterus After Hysteroscopic Septoplasty: A Retrospective Study in Chinese Women
Authors: Lan Zhu , He Run , Zhou Shanshan , Xia Guangji , Long Ying , Fu Jing , Xi Mingrong , Ouyang Yunwei
Published: January 2022

Objective

Septate uterus is the most common structural uterine anomaly, which is related to the adverse pregnancy outcomes in women of childbearing age. At present, there are still controversies about the surgical treatment of septate uterus both nationally and internationally. This article provides a retrospective review of hysteroscopic uterine septum resection performed in our hospital during recent years, focusing on the patients with recurrent miscarriage and infertility.
Methods

This is a single-center retrospective cohort study. Cases of women who underwent hysteroscopic septum resection at West China Second Hospital of Sichuan University from January 2014 to December 2019, retrieved through the medical record system, were divided into three groups: Group A was the recurrent miscarriage group, Group B had a history of pregnancy with spontaneous abortion once at most; Group C was the primary infertility group. Each patient was followed up by telephone about further pregnancy, miscarriage, and live birth for at least 1 year.
Results

A total of 176 surgical patients were included in this study. The overall pregnancy rate increased from 65.91–77.27% after surgery, the live birth rate increased from 7.95–67.61%, and the spontaneous abortion rate decreased from 46.59–17.05%. The postoperative pregnancy and spontaneous abortion rates in Group A were not significantly different from the other two groups, but the live birth rates were still significantly lower. For patients with complete uterine septum, the preoperative pregnancy rate was 54.84%, which was significantly lower than patients with partial uterine septum (71.93%). After hysteroscopic metroplasty, the pregnancy rate increased to 85.48% in patients with complete uterine septum, and 72.81% in the partial uterine septum group, but no statistical difference was observed.
Conclusions

After uterine septum resection, the overall pregnancy rate and live birth rate increased, and the spontaneous abortion rate decreased. However, the postoperative live birth rate and term delivery rate of RSA patients were significantly lower than other two groups. Patients with complete uterine septum may benefit more from surgery. The surgical indications should be carefully and strictly evaluated.
A Current Approach to Mean Temperature Trends and Relationships With Teleconnection Patterns in California (U.S.)
Authors: Pérez Alejandro González , Merino Ángel Penas , González Sara del Río , Estebán Ramón Álvarez
Published: January 2022

The aim of this research is to expand our knowledge of space-time evolution of mean temperatures at a regional level, for the whole California (United States) over 40 years. This study analyses the relationship between mean temperatures and teleconnection patterns with most influence on the Californian Climate. 170 meteorological stations were used with an observation period that ranged from 1980 to 2019. In order to evaluate the presence or absence of trends, the non-parametric Mann-Kendall test was used. The slope was obtained with a modified Sen’s slope method. The homogeneity of the data from the selected stations was verified. To find out the relationships between temperature and a wide range of teleconnection patterns in California was performed a correlation analysis using the partial non-parametric Spearman Test at a 95% confidence level. Spatial analysis was achieved using Empirical Bayesian Kriging (EBK). During this period, the results show a positive and significant trend annually, monthly and seasonally. Both Pacific Decadal Oscillation (PDO) and West Pacific Oscillation (WPO) are related to temperatures in California State during the period studied.
Retiboletus Huanggangensis, A New Species of Retiboletus From China
Authors: Zhou Fan , Gao Yang , Song Hai-Yan , Hu Hai-Jing , Li Shuo-Xi , Liu Jin-Hao , Hu Dian-Ming
Published: January 2022

A new species of the genus Retiboletus, Retiboletus huanggangensis, collected from Huanggang mountain, Wuyishan Nature Reserve, Yanshan County, Shangrao City, Jiangxi Province, China, is described based on morphological and phylogenetic analysis, nuclear ribosomal large subunit (nrLSU), the translation elongation factor1-α gene (TEF1-α) and the RNA polymerase II second largest subunit gene (RPB2) were used for phylogenetic analysis. Retiboletus huanggangensis is morphologically characterized by its white to grayish black to black pileus, white to pale yellow to black stipe, white to pale yellowish white hymenophore, white to grayish white or pale yellow context, prominently and coarsely reticulate over the upper 3/4 or overall, changing orange yellow to rusty yellow when its pileus injured. For phylogenetic analysis, the specimens from Huanggang mountain, grouped together with Retiboletus fuscus, but they have some morphological differences, Retiboletus fuscus has slightly narrower basidia, and pileipellis much narrower. Descriptions and hand drawings of the new species and comparisons with similar species are shown below.
Engineered E. coli for the targeted deposition of therapeutic payloads to sites of disease
Authors: Lynch Jason , González-Prieto Coral Coral , Reeves Analise , Powale Urmila , Godbole Neha , Tremblay Jacqueline , Schmidt Florian , Ploegh Hidde , Glickman Jonathan , Leong John , Shoemaker Charles , Garrett Wendy , LESSER CAMMIE
Published: January 2022

New drug platforms are needed which enable the directed delivery of therapeutics to sites of disease to maximize efficacy and limit off-target effects. Here, we report the development of PROT3EcT, commensal Escherichia coli engineered for the direct secretion of proteins into their surroundings. PROT3EcT are composed of four modular components: an E. coli chassis, a modified bacterial protein secretion system, a regulatable transcriptional activator, and a secretable therapeutic payload. PROT3EcT that secrete functional single-domain antibodies, nanobodies (Nb), stably colonize and maintain a functional secretion system within the intestines of mice. A single prophylactic dose of PROT3EcT that secretes a tumor necrosis factor alpha (TNFα) neutralizing Nb is sufficient to ablate TNF levels and prevent the development of injury and inflammation in a chemically-induced model of inflammatory bowel disease. This work lays the foundation for the development of PROT3EcT as a therapeutic platform for the treatment of at least gastrointestinal-based diseases.
High-Performance and Biodegradable Composites Based on Well-Characterized Cellulose and Poly (Butyleneadipate-Co-Terephthalate)
Authors: Jiang Guichang , Li Peipei , Qin Yiqing , Xu Qi
Published: January 2022

As a flexible biodegradable polymer, polybutylene adipate-co-terephthalate (PBAT) is used for packing. However, high cost and limited properties restrict its applications. Due to the hydrophobic nature of poly butylene terephthalate (PBAT), low mechanical properties are especially showed when PBAT and the hydrophilic nature of cellulose blend. Here, in order to increase the interfacial adhesion between cellulose and PBAT, the γ-(2,3-epoxypropoxy) propytrimethoxysilane (KH560) was used as a reactive compatibilizer to modify cellulose. We demonstrate the method of one-step compounding and subsequent extrusion blowing, which is a simple and environmentally-friendly approach to fabricate a series of K-Cellulose/PBAT (KH560-Cellulose/PBAT) composites. The morphology and structure of the cellulose were measured by scanning electron microscopy, X-ray diffraction (XRD) and Fourier transform infrared spectrophotometer (FTIR). Meanwhile, thermal analysis of the hybrids showed an improvement of the thermal stability of the composites upon increasing the silanized cellulose content. In addition, the barrier properties of films are measured by WVP and OP. Finally, after adding reactive compatibilizer KH560, mechanical properties testing of the samples showed considerable improvement with increasing the cellulose content. Therefore, the composites prepared with these enhanced properties have great potential as substitutes for traditional commodity polymers.
Pan-Cancer Analysis of the Prognostic and Immunological Role of Thymocyte-Expressed Positive Selection-Associated Protein 1 (TESPA1) in Human Tumors
Authors: Liu Lingyu , Liu Yufei
Published: January 2022

Background: Thymocyte-expressed positive selection-associated protein 1 (TESPA1) was identified playing a critical role responsible for T cell development in the thymus. Evidence has built the relationship between TESPA1 and cancers, but no pan-cancer analysis is available. Methods: We explored the expression patterns, prognostic values and immunological roles of TESPA1 across thirty-three cancers based on the datasets of TCGA and GEO via multiple databases and analysis tools, including Oncomine, TIMER 2, GEPIA 2, Kaplan–Meier Plotter, Prognoscan, UALCAN, cBioPortal web, STRING website, DNMIVD and GO/KEGG analysis. Results: We have demonstrated the different expression level of TESPA1 gene across pan-cancers and pathological stages. Furthermore, different expression level of TESPA1 gene correlated with prognosis of different cancer. A group of factors, such as DNA methylation, genetic alteration, protein phosphorylation and relevant cellular pathways are included differently compared with normal tissues, further related to prognosis. In addition, TESPA1 expression correlate positively with immune infiltrates, especially CD8 + T cells. Moreover, blood coagulation disorders were involved in the functional mechanisms of TESPA1. Conclusions: Our findings supported TESPA1 could serve as a pan-cancer prognostic and immune-related biomarker and play a vital role in tumorigenesis.
Identification Of Immune Networks Influenced By Mir-200c In IDH1-Mutant Lower-Grade Gliomas Using WGCNA
Authors: Duan Yunxia , Li Linan , Li Pengzhu , Duan Peng , Liu Hua , Gan Ling
Published: January 2022

Gliomas are the most common intracranial tumors with a highly invasive nature and poor prognosis. Different stages of gliomas have distinct alterations in genome, genetic and epigenetic changes. Here, we performed enrichment analysis and weighted gene correlation network analysis (WGCNA) on the Cancer Genome Atlas (TCGA) RNA-seq dataset to identify core genes and potential pathways involved in Isocitrate Dehydrogenase 1 (IDH1) mutant lower-grade gliomas (LGG). The IDH1-mutant LGG patients were found to frequently co-occur with abundant genetic alterations, surprisingly, the miR-200c/141 remain unchanged. Although located in close proximity, the expression level of miR-200c was more affected by methylation level and copy number variation than that of miR-141 in IDH1-mutant LGG. GO analysis indicated the high correlation between miR-200c and immune response. Gene set enrichment analysis (GSEA) suggested that leukocyte activation, inflammatory response, lymphocyte activation and adaptive immune response were significantly up-regulated in miR-200c high-expression group. Enrichment analysis demonstrated that leukocyte activation, immune response, lymphocyte proliferation, cell-cell adhesion and other items were participants in IDH1-mutant LGG samples. Furthermore, WGCNA yielded 33 significant modules, including the yellow module which contains genes involved in the immune response. Taken together, these results proposed a promising new therapeutic strategy for treating LGG gliomas through a miR-200c-mediated immune response pathway.
Synthesis and Luminescent Properties of 1,4,5-Triphenylimidazole‒Phenothiazine Fluorophores
Authors: Qian Long , Yang Hongyan , Zhao Yuling , Guo Yongchun , Yu Tianzhi
Published: January 2022

Two blue donor-acceptor fluorophores with 1,4,5-triphenylimidazole as the electron-transporting unit and phenothiazine as the hole-transporting unit were synthesized by grafting 1,4,5-triphenylimidazole moieties onto 3- and 3,7-position of the phenothiazine core and characterized by spectroscopic methods. Their thermal stability, photophysical, electrochemical and electroluminescence properties were systematically investigated. These compounds exhibit good thermal stability and show blue emission in dichloromethane solution and thin solid films. The solution-processed doped devices were fabricated by using these fluorophores as the emitting dopant in 1,3-bis(N-carbazolyl)benzene host, in which the device fabricated from the fluorophore containing two 1,4,5-triphenylimidazole moieties exhibited blue emission with a luminance of 648 cd/m2 and external quantum efficiency of 1.48%.
Cystatin C: A Potential Predictor for Acute Kidney Injury in Patients With Community Acquired Pneumonia
Authors: Chen Dawei , Jiang Linglin , Ma Mengqing , Huang Wenjuan , Tan Yan , Ji Xiaobing , Pan Binbin , Wan Xin
Published: January 2022

Background: Acute kidney injury (AKI) is common in patients with community acquired pneumonia (CAP), and associated with poor prognosis. Cystatin C had been demonstrated to be a biomarker for the early detection AKI in in several other clinical settings. Therefore, in this study we evaluated whether AKI in patients with CAP could be well predicted by serum Cystatin C within 24 hours after admission.Methods: Univariate and multivariate logistic regression analyses were used to investigate independent factors of AKI in patients with CAP. Prediction performance of all independent factors for AKI was measured using area under the receiver operating characteristic (ROC) curves (AUCs).Results: 2716 patients with CAP were eligible in this study, and 766 (28%) patients developed AKI. After multivariate logistic regression analysis, Cystatin C, albumin, uric acid, platelet count, white blood cell count, CURB-65 score, and acute respiratory failure were independent factors for AKI in patients with CAP. The maximum AUC was reported for serum Cystatin C within 24 hours after admission. Cystatin C had an AUC of 0.81 (95% CI: 0.79–0.83, P < 0.001) for predicting AKI, with an optimal cut-off value of 1.37 mg/L, computing 68% sensitivity, 80% specificity, 57% positive predictive value and 86% negative predictive value. In the stratification analyses, Cystatin C still had a good performance for predicting AKI in all the subgroups (AUCs: 0.69-0.84).Conclusions: The level of serum Cystatin C within 24 hours after admission appears to be a good biomarker for predicting of AKI in patients with CAP.
SARS-CoV-2 specific T cells induced by both SARS-CoV-2 infection and mRNA vaccination broadly cross-recognize omicron
Authors: Lang-Meli Julia , Luxenburger Hendrik , Wild Katharina , Karl Vivien , Oberhardt Valerie , Alizei Elahe Salimi , Graeser Anne , Reinscheid Matthias , Roehlen Natascha , Giese Sebastian , Ciminski Kevin , Götz Veronika , August Dietrich , Rieg Siegbert , Waller Cornelius , Wengenmayer Tobias , Staudacher Dawid , Bengsch Bertram , Kochs Georg , Schwemmle Martin , Emmerich Florian , Boettler Tobias , Thimme Robert , Hofmann Maike , Neumann-Haefelin Christoph
Published: January 2022

The SARS-CoV-2 variant of concern (VOC) omicron (B1.1.529) is associated with high infectivity and efficient evasion from humoral immunity induced by previous infection or vaccination. In omicron-infected individuals who have been vaccinated or infected before, severe disease seems to be relatively infrequent pointing towards protection by previously primed SARS-CoV-2-specific T cells that cross-recognize omicron. By performing a comprehensive in-depth comparison of the SARS-CoV-2-specific T cell epitope repertoire after natural infection versus after mRNA vaccination, we here demonstrate that spike-derived epitopes are not dominantly targeted in convalescents compared to non-spike epitopes. In vaccinees, however, we detected a broader spike-specific T cell response compared to convalescents reflected by a more diverse repertoire of dominantly targeted spike-specific T cell epitopes. Booster mRNA vaccination induced a broader spike-specific T cell response in convalescents but not in vaccinees with complete initial vaccination. In convalescents and vaccinees, the targeted T cell epitopes are broadly conserved between ancestral and omicron SARS-CoV-2 variants. Hence, our data emphasize the relevance of mRNA vaccine-induced spike-specific CD8+ T cell responses in combating emerging SARS-CoV-2 VOC including omicron and support the benefit of also boosting convalescent individuals with mRNA vaccines.
Longitudinal In-Vivo Quantification of Tumour Microvascular Heterogeneity by Optical Coherence Angiography in Pre-Clinical Radiation Therapy
Authors: Allam Nader , Zabel W. Jeffrey , Demidov Valentin , Jones Blake , Flueraru Costel , Taylor Edward , Vitkin I. Alex
Published: January 2022

Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment due to its logistical and potential therapeutic benefits as compared to conventional radiotherapy. However, its mechanism of action is yet to be fully understood, likely involving the ablation of tumour microvasculature by higher doses per fraction used in SBRT. In this study, we hypothesized that longitudinal imaging and quantification of the vascular architecture may elucidate the relationship between the microvasculature and tumour response kinetics. Pancreatic human tumour xenografts were thus irradiated with single doses of 10, 20 and 30 Gy to simulate the first fraction of a SBRT protocol. Tumour microvascular changes were monitored with optical coherence angiography for up to 8 weeks following irradiation. The temporal kinetics of two microvascular architectural metrics were studied as a function of time and dose: the diffusion-limited fraction, representing poorly-vasculatized tissue >150 µm from the nearest detected vessel, and the vascular distribution convexity index, a measure of vessel aggregation at short distances. These biological metrics allowed for dose dependent temporal evaluation of tissue (re)vascularisation and vessel aggregation after radiotherapy, showing promise for determining the SBRT dose-response relationship.
The Efficacy And Safety of Anlotinib Combined With Platinum-Etoposide Chemotherapy As First-Line Treatment For Extensive-Stage Small Cell Lung Cancer: A Chinese Multicenter Real-World Study
Authors: Zheng Hao-Ran , Jiang Ai-Min , Gao Huan , Liu Na , Zheng Xiao-Qiang , Fu Xiao , Ruan Zhi-Ping , Tian Tao , Liang Xuan , Yao Yu
Published: January 2022

Background: Anlotinib, an antiangiogenic multi-target tyrosine kinase inhibitor (TKI), was approved as the third-line and above treatment for small cell lung cancer (SCLC) in China. Some small sample size clinical trials have shown the favorable efficacy of anlotinib combined with platinum-etoposide chemotherapy as the first-line treatment for extensive-stage SCLC (ES-SCLC). This research aimed to explore the real-world efficacy and safety of anlotinib combined with platinum-etoposide chemotherapy.Methods: Pathologically confirmed ES-SCLC patients receiving anlotinib plus platinum-etoposide chemotherapy as the first-line treatment were enrolled in this retrospective study. The primary endpoint of this study was progression-free survival (PFS), and secondary endpoints included overall survival (OS), objective response rate (ORR), disease control rate (DCR), and adverse reactions.Results: In total, 58 patients were included in this study. The median PFS was 6.0 months [95% confidence interval (CI): 3.5-8.5], and the median OS was 10.5 months (95%CI 8.7-12.3). Thirty-four patients achieved partial response (PR), 18 patients achieved stable disease (SD), and 6 patients achieved progressive disease (PD). Respectively, the ORR and DCR were 58.6% and 89.6%. The main treatment-related adverse reactions were generally tolerated. The most common adverse reaction was myelosuppression (44.8%), followed by hypertension (41.4%), fatigue (34.5%), gastrointestinal reaction (32.7%), hand-foot syndrome (24.1%), and so on. Multivariate analysis showed that post-medication hand-foot syndrome [PFS 8.5 vs. 5.5 months, Hazards Ratio (HR)=0.23, 95%CI 0.07-0.72, P =0.012] was the independent predictor of PFS, and hypertension (OS 15.9 vs. 8.3 months, HR=0.18, 95%CI 0.05-0.58, P =0.005) was the independent predictor of OS.Conclusion: Anlotinib combined with platinum-etoposide chemotherapy as the first-line treatment for ES-SCLC appears to be effective and well-tolerated in the real-world. Patients with post-medication hypertension and hand-foot syndrome may confer superior prognosis. Further investigations are needed by prospective studies with larger sample size.