bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and morphological features of the endometrium in infertility in women referred for IVF
Authors:   Novosibirsk State Medical University, Volchek А.V. ,   State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia, Makarov K.Yu. ,   Novosibirsk State Medical University, Kuleshov V.М. ,   Novosibirsk State Medical University, Aidagulova S.V. ,   Novosibirsk State Medical University, Marinkin I.О. ,   Novosibirsk State Medical University
Published: December 2024

Introduction. Infertility in women is being a difficult social and medical problem for resolving, especially in the case of a chronic endometritis diagnosis with a variant of so called “thin” endometrium.
Aim. To study the clinical and morphological features of the endometrium in infertility in women referred for in vitro fertilization (IVF).
Materials and methods. The clinical data and results of immunohistochemical examination of the endometrium were studied in 181 women aged 30 [22; 38] years who were referred for IVF and gave birth. The causes of reproductive dysfunction were thin endometrium (group 1, 64 patients), fallopian tube obstruction (group 2, 55 women) and male factor infertility (group 3, 62 cases). The examination of patients included ultrasound imaging. In Pipelle biopsies of the endometrium before the IVF procedure, the number of pinopodia in the epithelium was assessed, the expression of HLA-DR and estrogen and progesterone receptors (ERs and PRs, respectively) was measured using immunohistochemistry. Nonparametric statistical tests were used.
Results. In women with infertility referred for IVF, a low percentage of endometrial pinopodia in the epithelium was detected in the secretory phase of the cycle. The lowest expression rates of HLA-DR, ERs and PRs were found in the endometrium of patients with tubal obstruction. At the same time, patients with thin endometrium had relatively high expression rates of ERs and PRs in the epithelium. The expression of ERs and PRs in endometrial stromal cells did not have statistically significant differences in pairwise comparisons.
Conclusion. In patients with thin endometrium, the formation of pinopodia has a high diagnostic significance for the receptive status confirmed by the ERA test, and does not depend on the PRs expression in the epithelium and stroma.
Changes in hematological parameters in rats with experimental atherosclerosis under chronic heavy metal intoxication
Authors:   Scientific Research Center, Azerbaijan Medical University, Ibragimov R.I.
Published: December 2024

Introduction. Exposure to heavy metals is an important and underestimated risk factor related to the development of atherosclerosis and its consequences. However, data on hematological changes in atherosclerosis under exposure to heavy metals could not be found in the literature, which was the reason for carrying out this study.
Aim. Study of changes in hematological parameters under chronic exposure to various heavy metals in experimental atherosclerosis.
Material and methods. The experiments were conducted on 110 outbred male albino rats which, after modeling atherosclerosis, were exposed to chronic heavy metals through drinking water for 60 days. The model of atherosclerosis was created according to I.V. Savitsky et al., based on the multifactorial theory of the development of atherosclerosis and its consequences. Cadmium sulfate, nickel nitrate and cobalt nitrate were used as toxicants. The measurement of hematological parameters was carried out using an automatic hematology analyzer.
Results. After intoxication with various heavy metals under conditions of experimental atherosclerosis, an aggravation of changes in hematological parameters, that occurred after modeling atherosclerosis, took place. The increased count of leukocytes, lymphocytes, platelets and erythrocytes in experimental atherosclerosis after chronic intoxication with heavy metals began to decrease, with the exception of the platelet count which continued to increase. The increased level of hemoglobin and mean corpuscular hemoglobin, which occurred in experimental atherosclerosis, continued to decline after intoxication. Maximum disturbances were observed by the 60th day of intoxication, and the most pronounced changes were noted under exposure to cadmium sulfate, then nickel nitrate and cobalt nitrate.
Conclusion. The presence of hematological disorders following the long-term exposure to heavy metals in experimental atherosclerosis necessitates to take these disorders into account in the comprehensive treatment of heavy metal poisoning, especially in older patients with atherosclerotic damage to the vessels.
Web Technology Innovations and Their Impact on Georgia’s Labor Market
Authors: Sturua Teimuraz , Todua Tea , Kobiashvili Ana
Published: December 2024

The development of modern web technologies is associated with unprecedented changes in the digital world around us. This fact determines the existence of diverse software support and technologies for creating websites. The web technology ecosystem is developing fast, driven by emerging technologies, changing user expectations, and the ongoing digital transformation across industries. This article explores the most significant trends reshaped web development in the latest period of time, highlighting the technological innovations that are redefining how developers create, deploy, and optimize digital experiences. From advances in frontend frameworks to the integration of artificial intelligence, serverless architectures, and enhanced performance optimization techniques, the current web technology landscape represents a dynamic intersection of innovation, efficiency, and user-centric design. The paper also discusses the latest trends in web technologies in relation to the Georgian labor market.
Frailty in elderly undergoing cardiac surgery
Authors: Rewurai Nichakan , Saetang Mantana , Sukkriang Naparat
Published: December 2024

บทคัดย่อ (Abstracts)
ปัจจุบันมีผู้สูงอายุที่มีภาวะเปราะบางที่ต้องเข้ารับการผ่าตัดหัวใจจำนวนมากขึ้น ซึ่งพบว่าภาวะแทรกซ้อน อัตราการเสียชีวิต ระยะเวลาการพักรักษาตัวและระยะเวลาการนอนโรงพยาบาลในหออภิบาลผู้ป่วยผ่าตัดหัวใจเพิ่มขึ้นมากกว่าผู้สูงอายุที่ไม่มีภาวะเปราะบาง ดังนั้นการประเมินความรุนแรงของภาวะเปราะบางก่อนผ่าตัดถือว่ามีความสำคัญมาก เพื่อวินิจฉัยภาวะเปราะบางได้อย่างรวดเร็ว และนำมาสู่การวางแผนดูแลรักษาผู้ป่วยที่ครอบคลุม ซึ่งสามารถลดความรุนแรงของภาวะแทรกซ้อน และอัตราการเสียชีวิตในระหว่างและหลังผ่าตัดหัวใจได้ บทความนี้จึงได้รวบรวมความรู้การประเมินความรุนแรงของภาวะเปราะบางก่อนผ่าตัด การดูแลผู้ป่วยที่มีภาวะเปราะบางทั้งระหว่างและหลังผ่าตัด เพื่อเป็นประโยชน์ในการดูแลผู้สูงอายุที่เข้ารับการผ่าตัดหัวใจ
Analysis of Narrative Writing Skills Among Junior High School Students in Indonesia
Authors: Yulianti Yulianti , Umar Umar , Sudewi Putu Wahyu , Isma Adi
Published: December 2024

Writing is a critical skill for English language learners, enabling them to express ideas effectively. This study investigates the narrative writing abilities of second-grade students at SMPN 5 Wonomulyo, Indonesia, focusing on five key aspects: content, organization, vocabulary, language use, and mechanics. Employing a mixed-method approach, data were collected through writing tests and teacher interviews. The findings reveal that a majority of students (60%) failed to meet the minimum standard of writing proficiency. Content and vocabulary were identified as the most challenging aspects, with many students struggling to generate coherent ideas and use appropriate language. Interviews with the teacher highlighted contributing factors, including limited vocabulary, lack of practice, and reliance on conventional teaching methods. The study emphasizes the need for innovative, student-centered approaches to enhance narrative writing skills, such as collaborative writing exercises, peer feedback, and digital storytelling tools. Vocabulary enrichment and regular writing practice are also critical for improving performance. This research contributes to the body of knowledge on EFL writing and offers practical recommendations for improving teaching practices.
Penggunaan Zeolit Alam Hasil Destruksi dengan Asam Klorida Untuk Adsorpsi Minyak Jelantah
Authors: Salim Ilham , Supeno Supeno , Bukorpioper Tamariska Selviana
Published: December 2024

Minyak goreng merupakan salah satu bahan yang dibutuhkan dalam pengolahan bahan makanan.penggunaan minyak goreng bertujuan agar makanan menjadi bercitarasa yang khas. Namun penggunaan minyak gores secara terus menerus akan menjadi minyak jelantah yang berdampak buruk bagi kesehatan jika digunakan untuk menggoreng. Oleh karena itu perlu dilakukan upaya peningkatan kualitas minyak jelantah tersebut.  Tujuan dari penelitian ini adalah untuk memberikan informasi tentang penggunaan zeolit alam hasil destruksi dengan HCl 6M untuk peningkatan kualitas minyak jelantah. Penelitian diawali dengan destruksi zeolit alam menggunakan HCl 6M kemudian ditentukan jenis mineral yang dihasilkan dengan XRD dan diameter pori menggunakan surface areameter NONA 1200  microanalyzer (Quantachrome). Kadar asam lemak bebas dan bilangan peroksidanya pada minyak jelantah ditentukan secara gravimetrc. Hasil penelitian menunjukkan bahwa tidak terjadi kerusakan struktur zeolit alam secara umum, namun jenis mineral utamanya masih modernit. Sedangkan diameter porinya meningkat menjadi 21,116 . Minyak jelantah yang digunakan sangat coklat kehitaman dan mempunyai kadar asam lemak bebas sebesar 2,23% dan bilangan proksida sebesar 5,02 meq/kg. Setelah dilakukan adsorbsi dengan zeolit alam termodifikasi yang diameter porinya sebesar  21,116 Å menghasilkan penurunan kadar asam lemak bebas sebesar   Bilangan peroksida dan kadar asam lemak sebesar 0,43% dan bilangan peroksida 0,61 meg/kg sehingga minyak yang telah diadsorbsi ini menjadi menjadi layak untuk digunakan sebagai minyak goring. Berdasarkan SNI untuk minyak goreng.
La Publicación Académica y las Actitudes de los Investigadores: Revisión Sistemática
Authors: Pérez Pulido Gelver
Published: December 2024

Introducción: La presente revisión sistemática tiene como objetivo explorar las actitudes de los investigadores hacia la publicación académica, identificando sus creencias y conceptos; opiniones y valores; emociones y sentimientos; estados de ánimo; tendencias e inclinaciones, así como las predisposiciones relacionadas con dicho proceso. Metodología: Se siguen las directrices PRISMA, abarcando estudios publicados entre 2019 y 2023 en las bases de datos Scopus, Web of Science, Eric y Dialnet. Para el análisis de la información se sigue la categorización con base en los tres componentes de la actitud. Resultados: Se marca la tendencia de los investigadores a presentar predisposiciones positivas hacia la publicación académica sin desconocer sus complejidades en los resultados, toda vez que se presentan mezclas de emociones y actitudes en medio de la presión tanto institucional como contextual por publicar. Discusión: se aborda la relevancia práctica de los hallazgos para los procesos de publicación académica por parte de los investigadores en sus instituciones y contextos Conclusiones: Las actitudes de los investigadores hacia la publicación académica son intrínsecamente complejas, afectadas por factores emocionales, contextuales e institucionales. La presión para publicar tiene un impacto considerable en las actitudes de los investigadores, especialmente entre los académicos más jóvenes.
Challenges facing education in the 21st century
Authors: Cunha Maria José dos Santos
Published: December 2024

Introduction: This article analyses the challenges facing education in this century, particularly regarding teaching and the school, the new roles that teachers are called upon to play, and their initial and continuing training, which has weakened due to constant change. Its objectives are to reflect on the need to change the aspects in question, aiming at improving the educational process. Methodology: For this purpose, a research methodology called bibliographic research was used. Results and discussions: the results point to the need for several changes that, as long as they are faced by all those involved with courage and a desire for change, can lead to the success of the educational process. Conclusions: The conclusions drawn are that, with a view to the educational process as a whole, education should be geared towards promoting skills and competences and rethinking new learning opportunities.
U progu zmian. Projekt wprowadzenia testamentu audiowizualnego do polskiego porządku prawnego
Authors: Pawłowska Izabela
Published: December 2024

Postęp technologiczny wpływa na wiele dziedzin życia. Nie bez wpływu pozostaje, także na regulacje prawne, które nie nadążają za zmianami. W wielu dziedzinach życia widoczna jest również tendencja do ułatwiania pewnych czynności i formalności. Polski projektodawca, proponuje wdrożenie do porządku prawnego pewnej nowości, o której jednak mówi się już od wielu lat, zarówno w Polsce, jak i poza jej granicami. Do tej pory, żaden z europejskich krajów nie wprowadził do swojego porządku prawnego oficjalnego testamentu audiowizualnego, ma się to zmienić, za sprawą propozycji polskiego Ministerstwa Sprawiedliwości. Celem niniejszego artykułu jest przeanalizowanie propozycja polskiego projektodawcy dotyczącej wprowadzenia testamentu audiowizualnego. Autorka zweryfikuje kierunek zmian, w kontekście innych możliwości, przede wszystkim w zakresie formy testamentu audiowizualnego. Poruszone zostaną kwestie związane z potencjalnym ryzykiem dotyczącym zmiany prawa w tym zakresie, a także korzyści, które proponowana zmiana może przynieść oraz korzyści, których proponowana zmiana nie przyniesie z uwagi na kształt proponowanych rozwiązań. Autorka  podejmie próbę oceny zmiany polskiego prawa spadkowego w kontekście testamentu audiowizualnego oraz zweryfikuje cel przyszłej nowelizacji.
Rozważania wokół prawnej dopuszczalności ograniczenia liczby kadencji organów wykonawczych gmin
Authors: Pyrzyńska Agata
Published: December 2024

W roku 2018 r. do polskiego systemu prawnego wprowadzona została zasada dwukadencyjności organów wykonawczych gmin. Celem artykułu jest analiza tej instytucji, w szczególności próba zweryfikowania, czy ujęcie tego rozwiązania w systemie prawnym stanowi ograniczenie praw wyborczych obywateli (przede wszystkim biernego, ale pośrednio także i czynnego), a także, czy przyjęte rozwiązanie jest zgodne ze standardami demokratycznego i uczciwego procesu wyborczego. W tym celu w pierwszej kolejności zbadano konstrukcję instytucji, a następnie przeanalizowano argumenty przemawiające za oraz przeciwko wprowadzeniu tego rozwiązania do polskiego prawa wyborczego. Szczególną uwagę poświęcono kwestii zgodności ograniczenia liczby kadencji organów wykonawczych gmin z Konstytucją RP. W pracy wykorzystano metodę formalnoprawną oraz dokonano przeglądu literatury przedmiotu.
Prawo pacjenta do opieki duszpasterskiej – wybrane problemy praktyczne
Authors: Białkowski Michał
Published: December 2024

Przedmiotem artykułu jest przysługujące pacjentom prawo do opieki duszpasterskiej. Podjęta tematyka ma szczególnie istotne znaczenie w świetle przemian zachodzących w polskim społeczeństwie, a także migracji (również z różnych od polskiego kręgów kulturowych) oraz rosnącej świadomości pacjentów w zakresie przysługujących im praw. Argumentem przemawiającym za podjęciem tej tematyki jest także złożoność regulacji prawnej normującej prawa pacjenta w tym obszarze, która wymaga od interpretatora sięgnięcia do różnych gałęzi prawa prywatnego (prawo cywilne, prawo rodzinne, narzędzia prawne służące do ochrony praw pacjenta) oraz publicznego (konstytucyjne ramy swobody sumienia i wyznania, organizacja ochrony zdrowia). W pracy zastosowano metodę dogmatycznoprawną wspartą przez analizę polskiego orzecznictwa sądowego.
Celem artykułu jest omówienie problematyki opieki duszpasterskiej świadczonej wobec pacjenta poprzez odniesienie się do praktycznych problemów związanych ze stosowaniem prawa. Stąd też w pracy poruszone zostały zagadnienia związane z realizacją prawa pacjenta w sposób zapewniający poszanowanie jego woli, w tym zagadnienie pozycji prawnej pacjenta małoletniego oraz pacjenta nieprzytomnego. Analizie poddana została także sytuacja wyznawców innych religii niż katolicka, dominująca na terenie Rzeczpospolitej Polskiej. Poruszone zostały także zagadnienia szczegółowe związane z rolą ograniczeń egzekucji sądowej i administracyjnej jako gwarancji realizacji omawianego prawa czy podmiotu zobowiązanego do ponoszenia kosztów opieki duszpasterskiej.
Artykuł dostarcza wniosków głównie dotyczących stosowania prawa, określając podmioty zobowiązane i uprawnione do realizacji prawa pacjenta do opieki duszpasterskiej. Fundamentem skutecznej realizacji uprawnień w tym obszarze pozostaje informacja o przysługującym prawie oraz sposobie jego wykonania. Niewątpliwie polski system prawny w zakresie ochrony autonomii woli pacjenta, niedyskryminacji mniejszości religijnych czy zasady ponoszenia kosztów związanych z wykonywaniem tego prawa przez podmiot leczniczy wpisuje się w europejski standard ochrony praw pacjenta.
Piąta edycja Praskich dialogów na temat relacji Państwo–Kościół: Opieka duchowa w instytucjach publicznych (II), Praga, 11–14 czerwca 2024 roku
Authors: Stanisz Piotr
Published: December 2024

Sprawozdanie z Piątej edycji Praskich dialogów na temat relacji Państwo–Kościół: Opieka duchowa w instytucjach publicznych (II), która odbyła się na Uniwersytecie Karola w Pradze (Czechy) w dniach 11–14 czerwca 2024 roku.
Ekonomiye dair yazdığı kitapları doğrultusunda Ahmet Mithat Efendi’nin iktisat düşüncesi
Authors: Demir Kenan
Published: December 2024

19. yüzyılda Osmanlı Devleti’nde uygulanan iktisat politikaları Batı kaynaklı düşünceler doğrultusunda şekillenmiştir. 1838’de imzalanan serbest ticaret anlaşması nedeniyle liberal iktisat düşüncesinin girişi hızlanmış ve bu düşüncenin yayılmasını sağlayan iktisatçılar ortaya çıkmıştır. 1840’lardan 1880’lere kadar öğretilen ve propagandası yapılan tek iktisat düşüncesi, liberal iktisat olmuştur. İktisat kitapları, gazeteler ve eğitim kurumları aracılığıyla bu düşünce yaygınlaşmış, ülkenin iktisat politikalarını ve zihin dünyasını şekillendiren tek iktisat düşüncesi haline gelmiştir. Ahmet Mithat Efendi, ülkedeki bu tek sese karşı çıkarak alternatif bir iktisat önermiş ve klasik iktisadın ülkenin iktisadi gerçeklerine uymadığını vurgulamıştır. Bu doğrultuda dört kitap yazmış ve bu kitaplarıyla Osmanlı Devleti’nde yeni bir iktisat düşüncesinin girişini ve gelişimini sağlamıştır. Ahmet Mithat Efendi’ye göre her ülke, kendi şartlarının gerektirdiği iktisat politikalarını uygulamalıdır. Bu yaklaşımına Merkantilistleri ve Fizyokratları örnek olarak göstermiştir.
Bir güzellik bilimi olarak estetiğin toplumsal koşullar karşısındaki evrimi
Authors: Temizer Merve
Published: December 2024

İnsanların kendilerini ve çevrelerini güzelleştirme ve bu durumdan hoşnut olmalarıyla ortaya çıkan estetik, sanat yanı sıra hayatımızın birçok alanında karşımıza çıkmaktadır. Başlangıçta, iyi ve doğru gibi ahlaki değerlerle ilişkilendirilen kavram on sekizinci yüzyılda farklı bir boyuta taşınmıştır. Bu yüzyılda İmmanuel Kant tarafından bağımsız bir değer olarak sınırları çizilmiş ve böylece ahlaki değerler ile olan ilişkisi sona ermiştir. Dolayısıyla bu çalışma, klasik sanatın ön koşulu olan bu olgunun, tarihsel süreçte üretiminden anlamlandırılmasına kadar olan dönüşümünü ele alınmaktadır. Çalışmanın amacı, modern sanata kadar bağımsız bir değer olarak etkinliğini sürdüren estetiğin modern dönemin toplum yapısı karşısında sahip olduğu nitelikleri nasıl yitirdiğini incelemektir. Dolayısıyla çalışmanın sonucunda modern sanata kadar sanatsal çalışmaların temel bir unsuru iken modern dönemde vuku bulan sosyolojik koşullar karşısında bu önceliğini kaybettiği anlaşılmıştır. Böylece estetik özne ile estetik nesne arasındaki bağın sarsıldığı ve bunun yerine alımlayıcının yorumu ve anlamlandırmasının ön plana alındığı görülmüştür. Çalışmanın bulgularından yola çıkarak klasik sanatın ön koşulu olan estetiğin günümüz koşullarına göre güncellenerek sanatsal çalışmalarda yer almasının değerlerimizin aktarılmasına katkı sağlayacağı düşünülmektedir.
A Comparison of Clinical Examination and Magnetic Resonance Imaging Results with Arthroscopy Results in Knee Intra-Articular Pathologies
Authors: Şahin Rıfat , Balık Mehmet Sabri
Published: December 2024

Objective: We aimed to determine in which of the symptomatic intra-articular pathologies of the knee, clinical examination and magnetic resonance imaging (MRI) can be an alternative to diagnostic arthroscopy.
Materials and Methods: Prospective analysis of 50 patients aged 18 to 50 years who underwent arthroscopy with the diagnosis of meniscus tear, cruciate ligament injury, cartilage damage, or plica between 2013 and 2015 was conducted. The results of the physical examination and MRI were compared with arthroscopy findings.
Results: Patients with a mean age of 35 years. Sensitivity, specificity, and accuracy rates in the Mc-Murray test were 90%, 11%, 76%; 76%, 33%, 68% in the Apley test; and 80%, 33%, 72% in the Ege’s test. Sensitivity, specificity, and accuracy rates in the MRI for the medial meniscus were 87%, 68%, 80%; 92%, 92%, 92% for the lateral meniscus; 36%, 95%, 62% for chondral injury; 90%, 95%, 94% for the anterior cruciate ligament; and 21%, 59%, 34% in the plica.
Conclusion: It should be noted that positive results can also be obtained in other knee intra-articular pathologies other than meniscus tear, as the sensitivity of these tests used to diagnose meniscus tear is high, but specificity is low. 1.5-tesla MRI has a high accuracy rate for detecting meniscus and anterior cruciate ligament injuries, while the diagnostic power of chondral surface evaluation remains limited, and high-resolution cartilagespecific images are required. As it is insufficient for evaluating plica on its own, it must be carefully incorporated during arthroscopy.
Reception of damage and activation of growth of connective tissue: crucial regulatory milestones of regeneration in humans
Authors: Eremichev R. Y. , Makarevich P. I.
Published: December 2024

Tissue damage activates programs aimed at the survivalof the body and restoration of its integrity, but fora long time the molecular and cellular mechanisms of theirimplementation remained undeciphered. In recent years, a number of importantinformation has been obtained about the regulation of regeneration processes,which significantly clarify a number of ideas about the regulationof the response to damage and deserve attention in termsof searching for new targets for controlling this process. Thisreview briefly summarizes the basic regulatory mechanisms associated with theearly stages of the human tissue response to injury. Italso provides current data on the mechanisms of damage receptionand the role of stromal cells in the formation ofprimary connective tissue as a structure that determines the outcome.
Genetically Encoded Biosensor HyPer as a Tool for Quantification of Intracellular Hydrogen Peroxide Concentrations
Authors: Lyublinskaya O. G. , Ivanova J. S.
Published: December 2024

This mini-reviewsystematizes information on methods for quantitative assessment of intracellular hydrogenperoxide concentration based on the use of a genetically encodedperoxide sensor HyPer. Two approaches are being considered: 1) calibrationof the biosensor using exogenous hydrogen peroxide, based on assessingthe rate of peroxide penetration into cells and intracellular peroxidaseactivity; 2) direct determination of the intracellular peroxide content, basedon measuring the level of oxidation of the biosensor, theoxidation reaction constant and the reduction reaction constant of HyPerin the cells. The use of these methods makes itpossible to solve a wide range of tasks in cellularredox biology—to determine the range of physiological anddamaging concentrations of hydrogen peroxide in cells, to evaluate theeffectiveness of the antioxidant defense system in various cellular compartmentsunder conditions of oxidative stress, to determine the contribution ofvarious enzymatic systems to the peroxidase activity of cells, andto characterize antioxidant defense systems in various biological contexts (inthe process of cellular senescence, differentiation, reprogramming, during the developmentof pathologies). The described methods can be adapted for othergenetically encoded hydrogen peroxide biosensors.
Human Health, Environmental Comfort and Well-Being. Part 1. Engineering and Design Resources of the Bioindustry on the Way to Safe Competition with the Resources of Natural Biocenoses and Health-Saving Systems
Authors: Suchkov S. V. , Abe H. , Murphy S. , Smith D. , Polyakova V. S. , Scherman D. , Glinushkin A. P. , Barach P. , Terentʼev A. O. , Tan M. , Suvorov A. N.
Published: December 2024

Everyone has the right to the highest attainable standard of health, and modern preventive, preventive and rehabilitative manipulations promote health and well-being. Thanks to a number of fundamental projects on the study of human health at various levels (genomic, proteomic, and metabolomic), and molecular mechanisms of the development of pathological conditions, there has been a great leap in the field of applied sectors of industrial biotechnology, including segments of the pharmaceutical and food industries, significantly replenished health-saving resources and improved the quality of life of the population. This article will review the advanced achievements of fundamental and applied research, as well as promising areas of the bioindustry.
Isolation of bioactive beta-glucans from mycelium of Pleurotus ostreatus mushroom
Authors: Frioui Mohamed , Yimer Getnet , Shamtsyan Mark , Barakova Nadezhda , Dozortseva Aleksandra , Kolesnikov Boris , Sadovoy Vladimir , Kiprushkina Elena
Published: December 2024

Background: Beta-glucan, a compound found in higher fungi, possesses significant properties important for the human body, including immunomodulatory effects. Developing efficient extraction technology is crucial to ensure a high yield of beta-glucan component while preserving its bioactive properties.
Context and purpose of this study: This study aimed to evaluate the extraction efficiency of beta-glucans from Pleurotus ostreatus mycelium powder using microwave-assisted extraction and to compare its performance with traditional extraction methods—specifically water and ethyl alcohol-based extractions.
Objective: The aim of this study is to increase the yield of the aqueous extract of beta-glucan from the mycelium of the fungus Pleurotus ostreatus, while ensuring its biological activity is preserved for subsequent use in the fortifying food products. To achieve this, various extraction methods were employed. 
Results: Traditional methods of beta-glucan extraction, including water and ethyl alcohol-based processes, yielded the largest amount of beta-glucan of 1.45 ± 0.02 g of beta-glucan. The stimulation index, a measure of beta-glucans on the human phagocytosis system, reached 1.28 under optimal conditions — double treatment with ethanol followed by a double extraction with water, each extraction lasting three hours. When extracting beta-glucan using microwave radiation, 2.97 g of beta-glucan was obtained—2.05 times greater than traditional methods. The simulation index also improved by 13%, reaching 1.47% while reducing the extraction time.
Conclusions: Based on the conducted research, it has been found that the extraction of beta-glucan from the mycelium of the Pleurotus ostreatus fungus is advisable to carry out using microwave processing, which significantly reduces the extraction time while maintaining the biological activity of beta-glucan.
Keywords: Basidiomycetes, Pleurotus ostreatus, beta-glucan, water extraction, ethyl alcohol extraction, microwave radiation, immunomodulatory properties.
Правове регулювання системи управління мінерально-сировинною базою Державного фонду надр України
Authors: Lytvyniuk S. F. , Lahoda O. A. , Netskyi O. V. , Burlutskyy M. S.
Published: December 2024

Із становленням незалежності українська геологічна галузь більшою мірою успадкувала нормативну та методичну структуру і механізми, які були утворені в рамках економічних, соціальних та інших умов існування колишніх радянських республік. За часи незалежності в Україні відбулися фундаментальні зміни законодавства у сфері надрокористування та формування мінерально-сировинної бази. В контексті визначення передумов створення надійної системи управління мінеральними ресурсами актуальним є аналіз чинної нормативної бази, пошук її недоліків та створення ефективної політики інтегрованого управління мінеральними ресурсами.Під час аналізу поточного нормативно правового стану та його змін у минулому був використаний широкий комплекс досліджень, який включав загальнотеоретичні методи наукових і прикладних досліджень. Окрім загальнотеоретичних методів аналізу, статистики та систематизації, для досягнення постановленої мети проведено структурний аналіз нормативно-правової бази геологічної галузі.Виконано узагальнюючий нормативно-правовий аналіз законодавчих документів геологічної галузі. Визначено перелік установ та підприємств, які займаються геологічним вивченням, промисловим освоєнням, обліком, моніторингом та контролем, який пов’язаний з мінеральними ресурсами. Під час досліджень встановлено інституційний взаємозв’язок “зацікавлених сторін” під час реалізації загальнодержавних програм, які формують головну стратегію управління Державного фонду надр України.Комплексний аналіз регуляторної політики у сфері управління мінеральними ресурсами виявляє обставини, що потребують урахування під час оновлення та внесення змін до чинних стратегій. Створення ефективної системи управління мінеральними ресурсами можливе в рамках узгоджених цільових національних стратегічних програм. Функціонування та розвиток такої системи управління має вирішальне значення для досягнення збалансованого управління ресурсами в умовах швидкозростаючих потреб промисловості.
Особливості моделювання флюїдів та фільтрації у низькопроникних колекторах газоконденсатних покладів
Authors: Lukin O. A. , Kondrat O. R.
Published: December 2024

Нарощування видобутку вуглеводнів в Україні передбачає залучення і впровадження у виробництво запасів, що пов’язані з низькопроникними газонасиченими колекторами. Все ще немає достатнього розуміння поведінки газового конденсату в ущільнених колекторах, що характеризуються високими конденсатно-газовими факторами, коли робочі вибійні тиски знижуються нижче тиску початку конденсації. Випадіння конденсату у пласті нижче тиску насичення призводить до зміни композиційного складу вуглеводневого газу та рідини, блокування частини порового простору, що, в свою чергу, знижує продуктивність свердловин. Можливості визначення якості, композиційного складу та впливу конденсату, який випав у пласті, на продуктивність свердловин у низькопроникних покладах є обмеженими. Прогнозування фазової поведінки флюїдів ускладнюється розмірами пор, що мають нанорозмірність, коли взаємодія між флюїдом та породою на молекулярному рівні може бути суттєвою. Досліджено за допомогою гідродинамічного симулятора композиційного типу ефект утворення валу конденсату та його вплив на продуктивність горизонтальних свердловин з багатостадійним гідророзривом, що експлуатують низькопроникні газоконденсатні колектори (0,001–0,1 мД). Проведено багатостадійний гідророзрив пласта у синтетичній горизонтальній свердловині, створено рівняння стану на базі лабораторних досліджень та побудовано композиційну гідродинамічну модель покладу. Результати моделювання показали суттєву зміну композиційного складу пластових флюїдів та відносної проникності для газу при значному зниженні пластового тиску. Було визначено композиційний склад конденсату, який випав у пласті. Це дозволить краще передбачати фазову поведінку під час прогнозування видобутку з низькопроникних газоконденсатних покладів.
The possibilities of lineament analysis using for quantitative assessment of the areas prospectivity for the hydrocarbon deposits searching (on the example of the Dnieper-Donets depression Northern board)
Authors: Khodorovskyi A. Ya. , Apostolov O. A. , Yelistratova L. O. , Romanciuc I. F.
Published: December 2024

The possibilities of applying the lineament maps issued on the base of remote sensing visual interpretation results is substantiated for assessment of potential area for hydrocarbon deposits search. The reliability of the results interpretation was assessed, which confirmed the correspondence of identified lineaments extension in relation to the discontinuous structures of crystalline rocks that determine the fracture permeability of rocks. The use of lineaments patterns spatial orientation coincidence with the known pattern of cracks and faults orientation was proposed. The reliability of faults corresponding to zones of increased number of lineaments was assessed by their spatial coincidence with the faults identified by geophysical data. The lineament density maps of the Earth’s thermic field, established by remote sensing data, were analyzed. It is shown that the lineaments and their density maxima, highlighted as a result of structural interpretation, correspond to discontinuous structures at different scale levels.Application of lineament density maps to assess the potential exploration area for hydrocarbon deposits is shown on the example of the Dnieper-Donets depression Northern board estimation. The area's prospectivity was assessed using the author's spatial-probabilistic forecasting program. The forecast map composed in a good agreement with the prospecting work results confirmed that the all known hydrocarbon deposits are located in the fields with the high prospectivity values. Deposits with the highest hydrocarbon reserves are characterized by the highest prospective values. The promising areas shown on the forecast map are located in the structural conditions similar to the known deposits location.The research performed on the Dnieper-Donets depression Northern board area proved the possibility and expediency of using the structural interpretation results of remote sensing data to estimate quantitatively the area prospectivity for the hydrocarbon deposits search based on a set of features.
Evaluation of endplate impact on tip loaded propeller performance using a RANSE solver
Authors: Sánchez-Caja A. , González-Adalid J. , Pérez-Sobrino M. , Saisto I.
Published: December 2024

Systematic variations of the endplate geometry for two endplate propellers are made in order to assess the impact of the blade tip shape on propeller performance. Several types of modifications are analyzed including variations in plate width, contraction angle, plate sweep and flap angle. The effect of endplate geometry modifications in the radial distribution of circulation is illustrated. The magnitude of the circulation is derived from the analysis of the tangential velocities behind the propeller. The contribution of pressure and friction components to the total endplate forces is also shown. Comparisons are made at full scale. A special procedure for the generation of the computational grids is implemented in order to minimize computational errors in the comparison of the alternative geometries. RANS code FINFLO is used in the evaluation.
Menological Dates in the Annals of Northeastern Rus, the mid-12th – the early 14th centuries
Authors:   National Research University “Higher School of Economics”, Vinogradov Andrey Yu.
Published: December 2024

The article discusses menological dates (after church feasts) in the chronicles of Northeast-ern Russia of the 12th – early 14th centuries, which were introduced contemporary to their writing. Original menological dates appear here under Andrei Bogolyubsky, from 1158, but his chronicle gives only 4 such cases. Although it is not possible to identify exactly the calen-dar used, it is most likely that it was the extended recension of the Prolog (Synaxarium) cre-ated in the 1160s, which may have been the impetus for the introduction of menological dates into the Vladimir chronicle. The dependence on the Prolog is undeniable for the chronicle of Vsevolod, where the number of menological dates increases sharply (85.5% of all exact dates). For the subsequent stages of chronicling, the source of the menological dates cannot be precisely determined. In the Vsevolodovichs’ era, all ‘ecclesiastic’ datings of key events decrease to 64.7%, and since 1261, the recording of key events without exact date be-gins to dominate (66.6%); so dating events according to the church calendar here is rather a tribute to the Vsevolod’s tradition. After the Mongol invasion, when the percentage of ‘ecclesiastic’ dates of events drops to 35, and events without dates increases to 45, the tendency towards the extinction of ‘ecclesiastic’ and even exact dating is visible, which is even clearer in the later chronicles.
MEDIA WAYANG DALAM PEMBELAJARAN SEJARAH KEBUDAYAAN ISLAM
Authors: Suhestiwi Rini , Junita Ika Elsa , Damayanti Novita
Published: December 2024

Penelitian ini mengeksplorasi penggunaan media wayang sebagai media dalam pembelajaran sejarah kebudayaan islam. Wayang yang memiliki akar budaya yang kuat di Indonesia, dapat menjadi media yang efektif untuk menyampaikan nilai-nilai sejarah islam kepada peserta didik. Melalui literature review, mengkaji bagaimana wayang dapat menghidupkan narasi sejarah islam, memperkaya pengalaman belajar, dan meningkatkan pemahaman peserta didik terhadap materi yang diajarkan. Hasil penelitian menunjukkan bahwa penggunaan wayang dalam pembelajaran sejarah kebudayaan islam tidak hanya meningkatkan minat dan partisipasi peserta didik ,tetapi juga membantu mereka menginternalisasi nilai-nilai kebudayaan islam dengan lebih mendalam.
ANALISIS BIBLIOMETRIK PENGGUNAAN TIK DALAM PAI
Authors: Affa Gilbrania
Published: December 2024

Perkembangan pesat teknologi infomasi dan komunikasi (TIK) terjadi di segala bidang tidak terkecuali Pendidikan Agama Islam (PAI). Proses pembelajaran PAI harus terus menyesuaikan dengan perkembangan TIK agar pembelajaran tetap relevan dan efektif. Penelitian ini disusun untuk (1) mengetahui literatur mana yang memiliki jumlah kutipan tertinggi; dan (2) mengetahui tren penggunaan TIK dalam PAI. Metode yang digunakan adalah analisis bibliometrik dengan aplikasi VOSViewer. Data penelitian dihimpun dari publikasi penelitian ilmiah melalui database Google Scholar dengan pencarian pada aplikasi Harzing's Publish or Perish (PoP) pada kurun waktu tahun 2019-2024. Pencarian kata-kata kunci pada judul dan abstrak penelitian menghasilkan 134 literatur relevan yang dipublikasikan. Hasil menunjukkan bahwa penelitian dengan tema penggunaan TIK dalam PAI paling banyak diteliti pada tahun 2022. R Rubiantica adalah penulis dengan kutipan tertinggi sebanyak 259 dengan judul penelitian Media Pembelajaran Interaktif Lectora Inspire Sebagai Inovasi Pembelajaran yang dipublikasikan tahun 2021. Topik yang jarang dibahas selain dari kata kunci ialah terkait manfaat, guru PAI, dan sekolah dasar. Keterbatasan penelitian ini hanya mengambil database pada publikasi yang ada di Google Scholar dalam kurun waktu 2019-2024 dan hasil pencarian pada PoP dibatasi sebanyak 200 literatur. Basis data nasional dan internasional lainnya tidak diperhitungkan dalam penelitian ini.
INOVASI PENDIDIKAN ISLAM BERBASIS KISAH AL-QUR’AN: MENELAAH INSPIRASI DAN IMPLEMENTASI DALAM PENGEMBANGAN PEMBELAJARAN
Authors: Setyaningrum Putri Nadha , Nida Sofwatun , Rahmawati3 Nur Widya , Isbah4 Moh Faliqul
Published: December 2024

Pendidikan Islam berkaitan erat dengan kisah Al-Qur’an. Banyak Pendidikan Islam yang terkandung dalam kisah Al-Qur’an. Tujuan dari penelitian ini yaitu untuk menelaah kisah Al-Qur’an sebagai sumber inovasi bagi pendidikan Islam. Penelitian ini menggunakan metode kepustakaan dengan pendekatan deskriptif yang bersifat kualitatif. Pada penelitian ini ditemukan bahwa dalam kisah Al-Qur’an terdapat banyak inspirasi untuk diterapkan dalam pendidikan Islam. Mengintegrasikan kisah Al-Quran ke dalam kurikulum dapat meningkatkan pengalaman pendidikan dan pertumbuhan spiritual siswa. Terdapat nilai-nilai pendidikan islam dalam kisah Al-Qur’an, diantaranya, nilai Pendidikan tauhid, nilai Pendidikan intelektual, nilai Pendidikan akhlak, nilai Pendidikan seksual, nilai Pendidikan spiritual dan nilai Pendidikan demokrasi. Adapun metode dari kisah Al-Qur’an yang dapat diterapkan dalam pendidikan Islam, seperti metode tarhib, metode keteladanan, metode ‘ibrah, metode belajar tuntas, dan lainnya. Implikasi dari penelitian ini yaitu, pendidikan Islam dapat diperkaya dan diperdalam melalui eksplorasi kaya nilai-nilai pendidikan yang terkandung dari kisah Al-Qur’an serta apa yang ada dibaliknya. Sehingga berimplikasi pada perkembangan serta peningkatan pada Pendidikan Islam.
SUMBER DAN MEDIA PENDIDIKAN ISLAM PERSPEKTIF AL-QUR'AN DAN HADITS
Authors: Anisa Hafilda , Adawiyah Rindang Rabi’ah , Nanda Hanafi Sal Shakhiba Albira , Basri Hasan
Published: December 2024

Penelitian ini mengkaji pentingnya sumber dan media pendidikan Islam dari perspektif Al-Qur’an dan Hadits. Pendidikan Islam mencakup seluruh aspek kehidupan, dengan Al-Qur’an dan Hadits sebagai sumber utamanya. Topik ini dipilih karena pendidikan Islam tidak hanya berfokus pada aspek spiritual dan moral, tetapi juga harus mampu mengintegrasikan teknologi dan media modern dalam proses pembelajaran. Di tengah pesatnya perkembangan teknologi, penggunaan media yang tepat menjadi kunci untuk menjembatani siswa dengan tantangan dunia modern, memperkuat pemahaman agama, serta meningkatkan kualitas hasil pembelajaran.  Penelitian ini menggunakan metode penelitian kepustakaan, mengumpulkan data dari buku, artikel, jurnal, dan sumber daring. Hasil penelitian menunjukkan bahwa Al-Qur’an, As-Sunnah, dan ijtihad merupakan sumber utama pendidikan Islam, sementara media pendidikan, baik yang tradisional maupun modern, terbukti efektif dalam merangsang minat belajar, memperkuat ingatan, dan meningkatkan prestasi akademik siswa. Penelitian ini juga menekankan perlunya inovasi berkelanjutan dalam pengembangan media pendidikan Islam untuk menghadapi tantangan era digital, sekaligus memastikan bahwa nilai-nilai Islami tetap relevan dan dapat diaplikasikan dalam kehidupan sehari-hari.
ESTABLISHMENT AND DEVELOPMENT OF EXCHANGE TRADING IN UKRAINE
Authors:   State University "Uzhhorod National University", Kazakova Lyudmila , Dziuba Vitalii ,   State University "Uzhhorod National University"
Published: December 2024

The stock exchange is the main component of the market infrastructure of a developed country. Exchange activity is accompanied by such effects as competitiveness, publicity, uniformity, variability, and the commodity exchange market is characterized by volatility, diversity, speculative activity, legal framework and technological progress. These elements collectively form the trading environment, influencing the behavior of market participants and the overall functioning of the market. As global economic dynamics continue to evolve, understanding these characteristics will be critical for all those involved in commodity trading, enabling them to effectively navigate the complexities of this vital sector. The development of the stock market is under the influence of globalization processes, which lead to the transformation of world economies and their transformation into a single market of capital, goods, services, information, labor, etc. In the last century, the leading place in world exchange trading belonged to contracts with real goods, and now the share of transactions with financial instruments has become predominant. It is noteworthy that, despite the extremely difficult conditions in which Ukraine is now, stock trading demonstrates stability and adaptability to the conditions that will arise. In Ukraine, stock trading plows its way through all the challenges and obstacles that private business in Ukraine faces, including bureaucratic obstacles, tax pressures, lobbying risks and regulatory gaps. As the main element of a market economy, stock exchanges provide the organization of trade in securities, agricultural goods and other assets. The stages that can be distinguished to generalize the periods of development of stock trading in Ukraine allow us to understand the risks that accompany this type of activity of such an institution in the process of the growth of the economy of our country. One of the important directions of development has become agrarian exchange trade,because Ukraine is one of the largest exporters of grain and oil crops in the world. At the same time, these years have seen the activation of digital technologies, which allows to significantly simplify trade processes and increase its efficiency.
ADVANTAGES AND DISADVANTAGES TOKENIZATION FOR ENTERPRISES
Authors:   Taras Shevchenko National University of Kyiv, Klimovych Stanislav
Published: December 2024

The article examines the advantages and disadvantages of asset tokenization for enterprises to determine the feasibility of implementing this technology in the context of the digital economy development. Tokenization is considered as an innovative method of attracting investments and managing capital, based on the use of distributed ledger technology. The essence of tokenization lies in the creation of digital tokens that represent certain real assets, such as stocks, bonds, real estate, etc. The paper analyzes the key benefits of tokenization for enterprises, including increased asset liquidity, lower entry threshold for investors, reduced transaction costs, and enhanced transparency of operations. The particular attractiveness of this technology for small and medium–sized enterprises, which often have limited access to traditional sources of financing, is noted. At the same time, the article explores the main disadvantages and risks associated with tokenization, including regulatory uncertainty, technological challenges, problems of property rights protection, and price volatility of tokenized assets. Practical recommendations for enterprises to minimize these risks are proposed, particularly through thorough study of the regulatory environment, assessment of technological aspects, and ensuring reliable protection of investors’ rights. Examples of successful cases of asset tokenization in various sectors of the economy are provided, demonstrating the practical feasibility and investment attractiveness of this technology. However, the need for further improvement of the regulatory environment and development of appropriate infrastructure for the widespread adoption of tokenization at the enterprise level is emphasized. The conclusions state that asset tokenization has significant potential to become one of the drivers of the digital economy development and transformation of traditional business models. It is emphasized that the rational use of this tool, considering its advantages and risks, can open up new opportunities for enterprises to attract capital and increase the efficiency of asset management in the context of dynamic technological changes.