bluuebunny/crossref_metadata_2025 huggingface dataset:
TRANSLATION INTERNSHIP MODULE: SUGGESTIONS FOR IMPROVEMENTS TO BETTER MEET THE COURSE OUTCOME STANDARDS AT THE FACULTY OF ENGLISH, HANOI OPEN UNIVERSITY
Authors: Pham Thi Bich Diep , Nguyen Thi Kim Chi  , Nguyen Thi Thu Huong, Vo Thanh Trung
Published: January 2025

The study aimed to assess the current implementation of the Translation Internship Module at the faculty of English, Hanoi Open University, so as to propose methods to evaluate the Translation Internship module in accordance with the orientation of developing the capacity to meet the course learning outcome. The study involved 235 last year English major students who have just completed the Translation Internship module, and data collection was conducted via a questionnaire survey and interviews to analyze students’ knowledge, skills, attitudes, and desires and synthesize teachers' opinions concerning module quality improvements. The findings reveal that most students chose topics based on popularity, appropriate language styles and structures, specialized vocabulary, diverse content, and reference sources. The study also shows that students employed adaptation and equivalent translation methods while source text features, namely vocabulary, content, style, language structures, and culture, were generally analyzed to illustrate students' knowledge and translation skills. The following outcome shows that a lack of both background knowledge and translation skills were students' major obstacles. Besides other issues regarding internship time, instructor-student interaction, and other supportive tools, assessment methods in accordance with the learner capacity assessment orientation were also discussed in the study.
SỰ ẢNH HƯỞNG CÁC YẾU TỐ KIẾN TRÚC MẠNG CONVNEXTV2 ĐẾN NHẬN DẠNG BIỂU CẢM KHUÔN MẶT TỪ DỮ LIỆU THỰC TẾ
Authors: Dương Thăng Long , Vương Thu Trang, Phạm Quang Huy
Published: January 2025

Thành công của các mô hình Transformer đã cho thấy hiệu suất xuất sắc trong các nhiệm vụ xử lý ngôn ngữ tự nhiên (NLP) đã được mở rộng sang lĩnh vực thị giác máy tính với các kiến trúc Vision Transformers (ViTs), đem lại kết quả tương đương hoặc vượt trội so với các mạng nơron tích chập (CNN) truyền thống trong các nhiệm vụ như nhận dạng hình ảnh và phát hiện đối tượng. Biến thể ConvNeXt V2, một mô hình cải tiến từ kiến trúc ResNet và kế thừa các điểm mạnh của kiến trúc ViTs như cấu trúc phân cấp các lớp nơron và cơ chế mã hóa tự động FCMAF nhằm mang lại hiệu suất cao và mô hình đơn giản hơn. Trong khi đó, nhận dạng biểu cảm khuôn mặt (FER) vẫn là một thách thức đối với các mô hình do hình ảnh trong thực tế bị các yếu tố như che khuất, biến đổi màu sắc và tư thế khuôn mặt. Nghiên cứu này áp dụng ConvNeXt V2 cho bài toán FER với việc điều chỉnh các tham số kiến trúc để đánh giá tác động của chúng trên dữ liệu thực tế của FER từ RAF_DB. Kết quả thử nghiệm cho thấy những yếu tố kiến trúc của ConvNeXt V2 tác động đến độ phức tạp của mô hình và chất lượng nhận dạng cho FER, cung cấp những phân tích ý nghĩa để làm rõ những vận dụng điểm mạnh của mô hình kiến trúc ViTs và kết hợp với các kiến trúc CNN truyền thống nhằm tăng thêm hiệu quả cho mô hình ứng dụng.
PHÁT TRIỂN KỸ NĂNG XANH CHO SINH VIÊN ĐẠI HỌC
Authors: Vũ Hương Giang, Nguyễn Thị Hương An  , Nguyễn Thành Trung, Trần Thu Phương  , Nguyễn Thị Hoài An*
Published: January 2025

Nghiên cứu đã hệ thống hóa một số vấn đề lý luận về kỹ năng xanh và  phát triển kỹ năng xanh cho sinh viên đại học. Theo đó, phát triển kỹ năng xanh được hiểu là quá trình học hỏi, trau dồi và cải thiện những kiến thức, kỹ năng, thái độ và giá trị của mỗi cá nhân nhằm giải quyết các vấn đề liên quan tới môi trường và bền vững. Để phát triển kỹ năng xanh cho sinh viên đại học, mô hình giáo dục phát triển bền vững ESD được phân tích với các phương pháp giáo dục tích hợp vào chương trình đào tạo thông qua các phương pháp học tập dựa trên vấn đề (PBL), học tập dựa trên dự án (PjBL) hoặc tích hợp PBL và PjBL để giải quyết các vấn đề về phát triển bền vững trong thực tiễn.
AI in data science education
Authors: Turner Stephen
Published: January 2025

Something a little different for this week’s recap. I’ve been thinking a lot lately about the practice of data science education in this era of widely available (and really good!) LLMs for code. Commentary at the top based on my own data science teaching experience, with a deep dive into a few recent papers below.
Book Review: Aline, G.; Holger, H. The Routledge handbook of second language acquisition and psycholinguistics; Routledge: New York, 2023; ISBN: 978-0-367-89376-7
Authors: Zhong Zilong
Published: January 2025

N/A
Python Programming: Beginner’s Guide
Authors: சுகந்தி முனைவர். சு.
Published: January 2025

பைதான் என்பது பல்துறை மற்றும் பரவலாகப் பயன்படுத்தப்படும் மொழியாகும், இது வலை உருவாக்கம் முதல் தரவு அறிவியல் வரை பல தொழில்களில் பிரதானமாக மாறியுள்ளது. பைதான் புரோகிராமிங்கின் அடிப்படைகளிலிருந்து மேம்பட்ட கருத்துகள் மற்றும் நுட்பங்களுக்கு உங்களை அழைத்துச் செல்லும் வகையில் இந்தப் புத்தகம் வடிவமைக்கப்பட்டுள்ளது. மாறிகள் மற்றும் தரவு வகைகளிலிருந்து செயல்பாடுகள், சுழல்கள் மற்றும் பொருள் சார்ந்த நிரலாக்கங்கள் வரை அனைத்தையும் நாங்கள் உள்ளடக்குவோம். புத்தகம் முழுவதும், முக்கியக் கருத்துகளை விளக்குவதற்கும் அவற்றை எளிதாகப் புரிந்துகொள்வதற்கும் நடைமுறை எடுத்துக்காட்டுகள் மற்றும் நிஜ உலகக் காட்சிகளைப் பயன்படுத்துவோம். நீங்கள் புதிதாக பைத்தானைக் கற்றுக்கொள்ள விரும்பும் ஒரு தொடக்கக்காரராக இருந்தாலும் சரி அல்லது உங்கள் திறமைகளை விரிவுபடுத்த விரும்பும் அனுபவமிக்க புரோகிராமராக இருந்தாலும் சரி, இந்தப் புத்தகம் அனைவருக்கும் ஏதாவது இருக்கிறது.
Hubungan Nilai Hematokrit dengan Jumlah Eritrosit pada Pasien Demam Dengue di Rumah Sakit Bhayangkara Kota Kediri
Authors: Nita Ermawati  , Erawati Erawati  , Yuliya Tyas Ismawanti
Published: January 2025

Dengue fever (DF) and dengue haemorrhagic fever (DHF) are infectious diseases caused by the dengue virus through the bite of aedes aegypti mosquitoes with clinical manifestations of fever, muscle or joint pain accompanied by leukopenia, rash, lymphadenopathy, thrombocytopeniaan dhemorrhagic dermatitis. Based on data from the Ministry of Health in 2020 in Indonesia until July, there were 71,700 cases. In addition, the number of deaths throughout Indonesia reached 459. However, the number of cases and deaths this year is still low comparedto 2019.This study aims to determine the relationship between hematocrit value and erythrocyte value in dengue fever patients at Bhayangkara Hospital, Kediri City. The sampling technique used was total sampling with a sample of 20 samples. Based on the results of the examination of hematocrit values with erythrocyte values in dengue fever patients at Bhayangkara Hospital, Kediri City in 25 June - 10 July 2024 from 20 samples obtained the results of low hematocrit 10 (50%) normal hematocrit 8 (40%) high hematocrit 2 (10%) and lowery throcytes 8 (40%) normalery throcytes 8 (40%) highery throcytes 4 (20%).
Pengaruh Massage Endorphine terhadap Penurunan Nyeri Punggung pada Ibu Hamil Trimester III di Wilayah Kerja Puskesmas Kuta Baro Aceh Besar
Authors: Fauziah Fauziah  , Ellyza Fazlylawati  , Wahyu Reci Fansari
Published: January 2025

From the results of a survey in the Kuta Baro Aceh Besar Health Center Work Area, there were 15 pregnant women and as many as 9 women who complained of severe back pain which was felt due to increasing gestational age, on average pregnant women were entering the third trimester or were approaching HPL (Day Estimated Birth). Meanwhile, 6 other pregnant women said they also felt pain but could still overcome it by lying down or reducing activity. The aim of the research is to determine the effect of endorphine massage on reducing back pain in pregnant women in the third trimester in the work area of the Kuta Baro Health Center, Aceh Besar. This research uses the Pre-Experiment method. The sample in this study used purposive sampling, namely the researcher determined 15 respondents to be used as samples. The results of the research are that there is an effect of endorphine massage on reducing back pain in pregnant women in the third trimester in the work area of the Kuta Baro Aceh Besar Health Center with a value of p = 0.000. Researchers hope that respondents can use it as a reference or guideline in dealing with back pain experienced in the third trimester.
Abses Hepar: Analisis Kasus dan Tinjauan Penanganannya
Authors: Matatula Christian Nugraha , Nikijuluw Helfi
Published: January 2025

Hepatic abscess is the most common type of visceral abscess. The annual incidence of hepatic abscess is reported to be 2.3 cases per 100,000 population, with a higher incidence in men compared to women. In this case, a 22-year-old male patient presented to the emergency department of Haulussy Regional General Hospital with complaints of generalized abdominal pain. Laboratory results showed a decrease in hemoglobin and lymphocytes, while leukocyte levels were elevated. Urea and SGPT levels were also increased, whereas albumin levels were decreased. The medical management provided to the patient in this case included surgical intervention in the form of exploratory laparotomy. Exploratory laparotomy is a surgical procedure performed by making an incision in the peritoneal cavity to allow the surgeon to directly visualize or inspect the internal organs of the abdomen. The procedure aims to obtain a clear view of the patient's abdominal condition, which cannot be definitively assessed through non-invasive examinations such as imaging studies.
Global drought-flood abrupt alternation: Spatio-temporal patterns, drivers, and projections
Authors: Chen Zeqiang , Li Xinghao , Zhang Xiang , Xu Lei , Du Wenying , Wu Lei , Wang Dinan , Zhang Yan , Chen Nengcheng
Published: January 2025

The spatiotemporal patterns and driving factors of drought-flood abrupt alternations (DFAA) have been investigated across several regional and watershed scales; however, comprehensive examination at the global scale is lacking. Here, we employed the long period drought-flood abrupt change index (LDFAI), derived from an ensemble of 40 output datasets from eight Coupled Model Intercomparison Project phase 6 (CMIP6) models, to assess the spatiotemporal patterns, drivers, and future projections of global DFAA. The results indicate that DFAA are influenced by various anthropogenic forcings, and greenhouse gas emissions exert the most significant impact. The changes in the intensity of global DFAA (1950–2014), attributed to natural forcing (NAT), anthropogenic aerosols (AER), and greenhouse gas (GHG) forcing, accounted for 5.65%, 14.57%, and 33.55%, respectively. The rates of change of the DFAA intensity under shared socioeconomic pathways (SSPs) from 2014 to 2100 were estimated to be 21.73% (SSP1-2.6), 45.37% (SSP2-4.5), 63.1% (SSP3-7.0), and 69.51% (SSP5-8.5). This means that under high radiative forcing, the regional rivalry and fossil-fuel development models will lead to a significant increase in DFAA. These findings can aid in the development of global adaptive policies related to DFAA.
Time-Driven Activity-Based Costing Analysis of Coronary Flow Velocity Reserve Assessment with Regadenoson Stress Echocardiography
Authors: Zheng Heming , Zhang Lijuan , Cao Ran , Zheng Xiaozhi
Published: January 2025

Objective: Accurate measurement of healthcare costs is required to assess and improve the value of Regadenoson stress echocardiography (RSE). The purpose of this study was to determine the costs associated with Regadenoson stress echocardiography. Methods: Time-Driven Activity-Based Costing (TDABC) was used to calculate the non-directly traceable cost of RSE. Data were collected between January 2021 and December 2023. TDABC steps involved (1) constructing process maps for the RSE pathway; (2) determining capacity cost rates for staff, medical equipment, space, water and electricity; (3) measuring the time required for each process through direct observation and participation and (4) calculating the total non-directly traceable cost of RSE. Finally, the total costs of RSE were obtained by summing up the direct retroactive cost and non-directly traceable cost. Results: Total costs of RSE were 1306.18 Chinese Yuan ($181.60), of which Regadenoson, human resources and equipment accounted for 61.09%, 19.96% and 13.17%, respectively. Conclusion: Regadenoson expense was the greatest contributor to the costs of RSE, followed by labor cost. Understanding the actual costs and cost drivers of RSE may better inform resource utilization to lower the cost and improve the quality of RSE.
The Role of Saudi Law in Regulating Digital Media and Combating Misleading Propaganda
Authors: Alqahtani Mohammed , Alqahtani Dahem , Alhilal Mishari , Aziz Kazem
Published: January 2025

This study aimed to reveal the role of Saudi law in regulating digital media and combating misleading propaganda in the Kingdom of Saudi Arabia. The study relied on the descriptive analytical approach. Data were collected through an electronic questionnaire that included 377 lawyers and media professionals in the Kingdom of Saudi Arabia, who were selected by simple random sampling. Descriptive and inferential statistical tests were used to analyze the data, such as mean, standard deviation, regression analysis, and correlation analysis. The results of the study showed a statistically significant positive relationship between the role of media professionals and lawyers in combating misleading propaganda and the effectiveness of Saudi law in this field. The results also showed that the role of media professionals and lawyers positively affects the clarity, strength, and application of the law. Based on these results, the study recommended the necessity of enhancing cooperation between media professionals and lawyers, developing awareness and training programs, reviewing laws and regulations, and encouraging scientific research in this field.
Skyrybos ir sutuoktinių socialiniai ekonominiai ištekliai
Authors: Maslauskaitė Aušra , Jasilionienė Aiva , Jasilionis Domantas , Stankūnienė Vlada
Published: January 2025

Lietuva išsiskiria vienais aukščiausių ištuokų rodiklių ES, kurie su nedideliais svyravimais iš esmės nekinta jau daugiau nei tris dešimtmečius. Nors skyrybos gana dažnos, beveik nėra tyrimų, nagrinėjančių ištuokų socialinį mechanizmą. Šio straipsnio tikslas – remiantis tiksliausia populiacijos lygmens, o ne atrankinių tyrimų informacija, atskleisti individo socialinių ekonominių išteklių įtaką ištuokos rizikai Lietuvoje. Pristatomas tyrimas* yra išskirtinis dėl savo empirinio šaltinio – 2001 m. gyventojų surašymo ir pirmųjų santuokų ir ištuokų registrų duomenų jungtinės bazės, kuri teikia informaciją apie visus susituokusius Lietuvos gyventojus. Nagrinėjama, kaip išsilavinimas ir užimtumo statusas modeliuoja skyrybų riziką vyrų ir moterų subpopuliacijose, kontroliuoja daugelį socialinių demografinių individualių ir partnerystės veiksnių. Tyrimas atskleidė, jog menki socialiniai ekonominiai ištekliai vyrams yra susiję su didesne skyrybų rizika, moterims žemas išsilavinimas mažina santuokos stabilumą, o užimtumo statusas neturi vienareikšmiško poveikio.
Sociological interpretations of data on the aggregate capital of regional population (work experience abroad, relation to labour migration, factors of life success)
Authors: Menshikov Vladimir , Vanags Eduards , Volkova Olga
Published: January 2025

In the present article, the authors continue their sociological interpretations of theempiric data obtained in the research project “Aggregate Capital, Its Structure andRelation to Labour Migration” (2012). The following hypothesis has been proved: ahigher predisposition for the labour migration is more typical for economically activeregion’s inhabitants with fairly high amounts of some indicators of the aggregatecapital, especially physical capital, but with a comparatively lower amount of culturalcapital, which could transform into human capital and further into economic capital inLatgale or Latvia. An in-depth analysis of the factors of life success has revealed that,in general, our respondents tend to assign the lead role not to the personal competitivecharacteristics (resources) but rather to the specificity of the social environment: anexplanation of life success by means of a set of variables that, on the whole, describeit as a socio-political innovation with criminal tendencies (political corruption) is themost spread one.
Dermatofibrosarcoma Protuberans, Version 1.2025, NCCN Clinical Practice Guidelines In Oncology
Authors: Bordeaux Jeremy , Blitzblau Rachel , Aasi Sumaira Z. , Alam Murad , Amini Arya , Bibee Kristin , Bolotin Diana , Chen Pei-Ling , Contreras Carlo M. , DiMaio Dominick , Donigan Jessica M. , Farma Jeffrey M. , Ghosh Karthik , Harms Kelly , LeBoeuf Nicole , Lukens John Nicholas , Manber Susan , Mark Lawrence , Medina Theresa , Nehal Kishwer S. , Nghiem Paul , Olino Kelly , Paragh Gyorgy , Park Soo , Patel Tejesh , Rich Jason , Shaha Ashok R. , Sharma Bhavina , Sokumbi Yemi , Srivastava Divya , Thomas Valencia , Tomblinson Courtney , Venkat Puja , Xu Yaohui Gloria , Yu Siegrid , Yusuf Mehran , McCullough Beth , Espinosa Sara
Published: January 2025

Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous soft tissue sarcoma and affects an estimated 1,500 people annually in the United States. DFSP frequently exhibits extensive local infiltration. Initial treatment is through surgical excision, and care should be taken to ensure that negative margins are achieved to minimize recurrence. Although DFSP has a reported high rate of recurrence, metastasis is more uncommon. Fibrosarcomatous DFSP is an aggressive variant with an increased risk for local recurrence and metastasis. If achieving negative margins or resection is not feasible, radiation therapy or systemic treatment are options that may be considered by a multidisciplinary team. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) outline recommended treatment options available for DFSP.
Pandangan Proses Transaksi PayLater Terhadap Perilaku Konsumtif Dalam Prespektif Ekonomi Syariah
Authors: Priska Cintya  , Fauzatul Laily Nisa
Published: January 2025

Digital transformation has shaped a more connected ecosystem and opened up new opportunities, particularly in the financial sector. One significant innovation is the Paylater payment service, which allows consumers to buy goods or services now and pay later. This service offers great convenience and flexibility, making it popular among consumers, especially millennials. The use of PayLater services in consumer transactions has become an increasingly relevant topic in the context of Islamic economics. However, the popularity of Paylater raises concerns from an Islamic economic perspective that emphasizes fairness, transparency, and usury-free. This research aims to provide a deeper understanding of how PayLater transactions are viewed within the framework of Islamic economics and how responsible financial management can be carried out in accordance with sharia principles. The research method used is descriptive with a qualitative approach carried out by deeply processing the results obtained from various literature sources. The results show that the use of PayLater services in consumer transactions is contrary to sharia law besides that it also causes excessive consumptive behavior, and the impact of uncontrolled debt accumulation which is prohibited in sharia law.
Analisis Pengaruh Regulasi Pemerintah Terhadap Penerapan Akuntansi Lingkungan
Authors: Amelia Nur Maharani  , Ersi Sisdianto
Published: January 2025

Abstrak. Government regulations play a critical role in promoting the implementation of environmental accounting, particularly in the context of sustainability and corporate social responsibility. This study aims to analyze the impact of government regulations on the adoption of environmental accounting across various industrial sectors. A descriptive approach was employed to examine the relationship between regulations and environmental accounting practices, using data collected from surveys and regulatory document reviews. The findings indicate that clear and stringent regulations enhance corporate compliance with environmental reporting; however, challenges persist due to limited understanding and resource constraints in certain companies. This study highlights the importance of collaboration between governments and corporations to establish effective regulatory systems that support environmental sustainability. In conclusion, well-designed government regulations can act as a catalyst for integrating environmental accounting into business practices, significantly contributing to global sustainability goals.
Keywords: government regulation; environmental accounting; sustainability; social responsibility
Pengaruh Kebijakan Tarif Bea Masuk Terhadap Ekspor Porang Ke Negara Jepang
Authors: Argya Abdullah , Sinambela Evita Irene Sheren , Pramesti Reva , Sya'bani Siti Fadhila
Published: January 2025

Prior to being hampered by the import regulations of destination nations, Indonesia's export of processed porang, especially from North Sumatra, saw tremendous growth. Examining how tariff regulations affect the competitiveness of processed porang exports to Japan is the goal of this study. Using a SWOT analysis and case study methodology, the study concludes that while Porang exporters have a lot of potential, export growth may be hampered by shifting tariff policy. To address these issues, the report suggests more assertive export tactics. The study demonstrates that one of the elements influencing the competitiveness of Indonesian porang products in the Japanese market is changes in tariff regulations by looking at export data from industry participants. The results have significant ramifications for how the government and business community can develop trade regulations to better encourage porang exports.
PROXIMATE COMPOSITION, MINERALS CONTENT, TOTAL PHENOLICS AND ANTIOXIDANT ACTIVITY OF TRADITIONALLY CONSUMED POSTPARTUM SUPPLEMENTAL FOODS
Authors: Kashif  , Muhammad Abbas  , Ahmad Ibne Yousaf  , Anza Ahmad  , Ayesha Bint Yousaf  , Zartasha Gul  , Azzah Khadim Hussain
Published: January 2025

The postpartum period is critical for maternal and newborn health, marked by significant physiological and emotional changes. Cultural and traditional dietary practices often play a vital role in restoring maternal health and promoting lactation. This study investigates the proximate composition, mineral content, total phenolic content, and antioxidant activity of traditionally consumed postpartum supplemental foods in eight districts of Khyber Pakhtunkhwa, Pakistan. Data were collected from postpartum women through interviews, and commonly consumed foods were selected for chemical analysis. The findings reveal that these foods are nutrient-dense, with significant amounts of macronutrients, minerals, and bioactive compounds. The study highlights the role of traditional dietary practices in maternal nutrition while emphasizing the need for a balanced approach combining cultural practices and medical guidelines. These insights can aid healthcare professionals in optimizing dietary plans for lactating mothers, ensuring improved maternal and neonatal health outcomes.
Carbon Nanotube-Based Glucose Biosensor: Preparation and Application
Authors: Wan Xiyan
Published: January 2025

Glucose biosensor is one of the most important sensors for converting glucose concentration into measurable signal. The use of biosensors for monitoring glucose has significant value in healthcare. It has attracted much attention in recent years because of its excellent real-time detection ability, high stability, minimally invasive and easy operation. Carrier and electron transport medium are important factors which affect the selectivity and sensitivity of biosensors. Therefore, the search for carriers with high specific surface area and excellent electrical conductivity is the key to promote the performance of glucose biosensors. Carbon nanotubes (CNTs) are excellent candidates for the modification of glucose biosensors due to their unique structure and excellent properties. In this paper, glucose biosensors are introduced briefly. The components, development, classifications and working principle of biosensors are introduced in detail. The biosensors used for detecting glucose are also outlined, including their composition, principles, development, and modifications. Especially the CNT-based sensors, which are formed by modifying the electrodes with CNTs, are described in detail. It is shown that CNTs combined with other nanomaterials could form composite materials which is very useful for improving the detection performance of glucose sensors. This work will promote real-time monitoring of glucose concentration.
The Application of Mindfulness in The Treatment of Borderline Personality Disorder
Authors: Duan Yike , Lv Xinyue
Published: January 2025

Borderline personality disorder is characterized by generally unstable patterns in emotional regulation, impulse control, interpersonal relationships, and self-image. It is always accompanied by some associated disorders, such as problematic alcohol use and self-harm. The cause of borderline personality disorder is well understood, with genetic factors and childhood abuse both contributing, and it is more common in women than in men. In this study, we also investigated the neuroscientific aspect of changes in the brains of people with borderline personality disorder. We wanted to find out about the effectiveness of mindfulness in the treatment of borderline personality disorder. Studies show that mindfulness practice affects psychological and neural processes and systems, leading to improved attentional capacity, body awareness and engagement in cognitive control processes, and recognising the therapy as a behavioural component to improve emotion regulation and reduce symptoms in people with borderline personality disorder. We proposed 3 hypotheses regarding the mechanism of mindfulness treatment in patients with borderline personality disorder. That is, mindfulness may affect borderline personality disorder by improving individuals' emotional regulation, reducing impulsivity, and inducing changes at the neurophysiological level.
Enhancing the Effect of PD-1/L1 Blockers by Polarizing M2 Tumor-associated Macrophages (TAMs)
Authors: Zhang Xinyan
Published: January 2025

The cancerous microcosm, known as the tumor micro-environment (TME), encompasses a highly intricate network where a multitude of cells and their emitted substances significantly contribute to the development and advancement of malignant growths. The role of TAMs in the TME has been increasingly valued. Owing to its significant plasticity, it typically divides into pro-inflammatory M1 and anti-inflammatory M2. Within TME, TAMs typically show polarization towards M2. Antibodies are used by PD-1/L1 blockers to prevent PD-1 and PD-L1 from binding, aiming to reduce tumor symptoms. Presently, the efficacy of this medication is limited to a select few patients, in contrast to other patients who exhibit a level of resistance to the drug. Latest research indicates that M2 TAMs exert a suppressive influence on the PD-1/L1 blockade treatment. This substance suppresses the growth and penetration of CD8+T cells and generates Indole 2,3-dioxygenase (IDO), resulting in resistance to PD-1/L1 inhibitors and facilitating the multiplication and evasion of cancer cells. Some studies have reduced the resistance to PD-1/L1 blockers and promoted the treatment of tumors by polarizing TAMs. The dissertation compiles identified TAMs polarization routes and the impact of M2 TAMs on PD-1/L1 inhibitors. The discussion also encompasses present-day techniques for directing M2 TAMs towards the M1 type and advocating these approaches on PD-1/L1 blockers.
The Effects of Social Media on Mental Health Among Adolescents
Authors: Li Shengwei
Published: January 2025

This study delves into the intricate relationship between social media and adolescents’ mental health, a pressing concern in the digital era. The development of social media is a product of the times and a reflection of social progress. For individuals, the impacts are diverse. Social media platforms, while promoting social interaction and a sense of belonging, also harbor dangers like addiction and cyberbullying that can negatively impact self-esteem and mental health. The paper offers a succinct literature review, emphasizing social media's dual impact as a source of support and stress for high school students. It highlights the pivotal role of mental well-being in countering social media's negative influences and advocates for additional research to develop strategies that encourage positive social media engagement. The study concludes with a call for a balanced strategy to maximize social media’s benefits for adolescents while protecting them from its potential detriments. This study explores the relationship between social media and the mental health of adolescents, a pressing issue in the digital age. The development of social media is a product of the times and a reflection of social progress. There are both positive and negative consequences for individuals. While social media platforms promote social interaction and a sense of belonging, they also pose dangers such as addiction and cyberbullying, which can harm self-esteem and mental health. The paper provides a concise review of the literature, emphasizing the dual impact of social media as a source of support and stress for students. It highlights the central role of mental well-being in countering the negative influences of social media and advocates for further research to develop strategies to promote positive social media engagement. The study concludes with a call for a balanced strategy to maximize the benefits of social media for young people while protecting them from its potential harm.
Preparation and Application of MOF-Based Electrochemical Sensors for Biomedical Detection
Authors: Xu Xin
Published: January 2025

In the field of biomedicine, sensor technology has become an ideal tool for health monitoring and medical services. Electrochemical methods are the most promising candidate technology for the detection due to their simplicity, high sensitivity and specificity. Electrochemical sensors ingeniously combine electrochemical technology with sensor technology. This kind of sensors can achieve efficient and accurate detection. The combination of health monitoring and big data technology poses new requirements for sensors. Achieving high precision, specific identification, and real-time monitoring have become the research directions of electrochemical sensors. Many new functional materials are used to modify electrodes to achieve these functions. Metal-organic frameworks (MOFs) have attracted a lot of attention in the last 20 years because of their special structure which gives them a great range of applications. This porous material helps the electrode capture target molecules, thereby achieving improved sensitivity. In recent years, there are an increasing amount of researches on MOF-based electrochemical sensors. Therefore, this work focuses on the discussion of electrochemical sensors and MOFs. In addition, electrochemical sensors based on MOFs for biomedical detection have also been summarized. This work will promote the application of sensor technology in health monitoring and biomedicine.
Compare the Treatment Effects of Various Therapies for Breast Cancer Based on Data Analysis
Authors: Zhao Yimeng
Published: January 2025

Breast cancer is one of the life-threatening tumors around the world. While some researchers have discovered a strong correlation between human health issues in contemporary society and the medication of breast cancer, a comparison of the impacts of different breast cancer treatments is still lacking in the literature. Thus, for the purpose of compare the therapeutic outcomes of targeted medication therapy, immunotherapy, and surgical treatment, this research gathers clinical treatment data and does SPSS data analysis. Research has demonstrated the efficacy of surgical intervention, immunotherapy, and targeted medication therapy in the managing the remedy of breast cancer. The specific targets of each therapeutic modality vary. Individuals diagnosed with advanced breast cancer may select several treatment options based on their unique circumstances.
The Mechanism of T Cells in the Microenvironment of Triple Negative Breast Cancer and the Application Potential of Immunotherapy
Authors: Qiao Jiayue , Wu Furong
Published: January 2025

Triple negative BC (TNBC) is a malignant tumor with high invasion, high incidence rate and poor prognosis. The mechanism of T cells in its microenvironment and the potential application of immunotherapy have become the focus of current research. Research has shown that the tumor microenvironment of TNBC is highly heterogeneous, and T cells, as core members of the immune system, play a crucial role in the anti-tumor process by recognizing and clearing tumor cells. However, T cell activity is often suppressed by ICs such as PD-1/PD-L1, leading to tumor immune escape. With the development of single-cell RNA sequencing technology, there is a deeper understanding of the functional status of T cells in the TNBC microenvironment. Meanwhile, IC inhibitors (ICIs) and adoptive cell immunotherapy have shown significant potential in the treatment of TNBC. For example, PD-1 inhibitors combined with chemotherapy significantly prolonged the lifespan of TNBC patients. The results of this study reveal that the activation of T cells in the TNBC microenvironment is closely related to tumor prognosis, and immunotherapy can improve the therapeutic effect of TNBC patients by regulating T cell activity. The research significance lies in providing new strategies for the precise treatment of TNBC, especially the broad application prospects of immunotherapy. In the future outlook, with the deepening understanding of the molecular mechanism and immune microenvironment of TNBC, as well as the development of new immunotherapy drugs, the prognosis of TNBC patients is expected to further improve, achieving more personalized and effective treatment plans.
Mechanisms of Action and Current Research Status of New Drugs For Cardiovascular Diseases (Cvds)
Authors: Wang Shaoyang
Published: January 2025

Cardiovascular diseases (CVDs) remain one of the leading causes of death and disability worldwide, posing a significant threat to global public health. In recent years, with the advancements in molecular biology and genomics, the development of new drugs for CVDs treatment has made substantial progress, particularly in the fields of anti-inflammatory, anti-fibrosis, and angiogenesis therapies. This thesis investigates the mechanisms of action of these innovative drugs and their clinical applications. Firstly, the critical role of anti-inflammatory drugs in CVDs is analyzed, highlighting how novel anti-inflammatory agents, such as IL-6 inhibitors, modulate immune responses to reduce cardiovascular inflammation. Secondly, anti-fibrotic drugs, such as TGF-β inhibitors, are discussed in detail, focusing on their ability to inhibit fibrosis progression and improve cardiac function by reversing myocardial fibrosis. Additionally, angiogenesis-based drugs, which promote endothelial cell repair and regeneration, are explored for their potential in enhancing microcirculation in the cardiovascular system. The thesis also delves into the prospects of personalized medicine and gene therapy in the development of new CVDs treatments. Emerging technologies, such as multi-target combination therapies, gene editing, and nanomedicine carriers, are expected to bring breakthroughs in the treatment of CVDs. This paper summarizes current research progress and explores future directions, providing theoretical foundations and practical insights for the development of novel drugs for CVDs.
Application of combination therapy for treating glioblastoma
Authors: Xu Xuanqi
Published: January 2025

Glioblastoma (GBM), an aggressive brain tumor with a high mortality rate, is also extremely easy to differentiate and metastasize, making it one of the most dangerous cancers in the world. The aim of this research was to establish a unique combination therapy that combines surgery and vaccination to treat GBM. This research uses predictive clinical trials and artificial intelligence analytics to summarize and examine the side effects and remedies of combination therapy, thus ensuring the physical and mental health of patients and aiming to create a low-cost treatment with a high success rate. Since angiogenesis is the most challenging side effect to treat, other remedies for this symptom were also summarized in this research. This means that this combination therapy may provide better success rates and a more patient-appropriate course of care compared to earlier approaches. It is hoped that in the coming time, this combination treatment plan will be adopted and implemented, and it is hoped that more efficient treatment methods will be proposed so that all GBM patients can be cured.
Analysis of Factors Attributing to Hepatitis B Vaccine Non-response
Authors: Chen Qiqi
Published: January 2025

Currently, 5-15% of hepatitis B vaccine recipients are non-responders despite the high global coverage 83% of the hepatitis B vaccine. The research of hepatitis B vaccine nonresponse had been going on for some time for the improvement of the vaccine and the objective to eliminate hepatitis B, this paper aims to summarize some of the factors contributing to hepatitis B vaccine nonresponse base of these previous studies after scrutiny. Factors contributing to hepatitis B vaccine nonresponse including HLA haplotypes, age, elder with comorbid condition, obesity, smoking, presence of micronutrient deficiency is involved in this paper. The understanding of these factors is important for the further progression of the vaccine, improvements like repeated vaccination, a booster dose, use of immune boosters, vaccine with a higher dosage, a different adjuvant, a more effective antigen, a different administration route of the vaccine, change of needle length when injecting the vaccine can be made considering the nonresponse factors, therefore increasing the efficacy of hepatitis B vaccine.
The Preparation of Nano-Titanium Dioxide and Its Healthcare Effects in Cosmetics
Authors: Wang Jianing
Published: January 2025

Cosmetics are an integral part of daily life. Nowadays, cosmetics are endowed with more healthcare functions while meeting people's needs for beauty enhancement. Nano-titanium dioxide plays a crucial role in their formulation because of its antibacterial and anti-inflammatory properties. As a new type of nanomaterial, nano-titanium dioxide has excellent properties. This paper explores the properties, preparation methods, applications, and potential hazards associated with nano-titanium dioxide in cosmetics. The study highlights its strong ultraviolet (UV) shielding capabilities, which are used in sunscreen products. The nano-titanium dioxide has good dispersibility and weather resistance. The preparation methods included sol-gel, hydrothermal, vapor deposition, and oxide reduction methods. The paper further discusses the use of nano-titanium dioxide in various cosmetic products such as sunscreens, lotions, and gels. Despite its advantages, the paper also displays safety concerns related to skin exposure, inhalation, and oral intake of nano-titanium dioxide. The material poses certain risks, its beneficial properties make it a valuable component in the cosmetic industry. The nano-titanium dioxide significantly enhances the functionality of cosmetics. This work contributes to its widespread use in the future.
Efficient CRISPR Cas13 in The Treatment of The COVID-19
Authors: Jian Manli
Published: January 2025

Currently, CRISPR Cas13 is one of the rapid advancement and growing potential in the fields of diagnostics and therapeutics. It has proven highly effective in detecting RNA viruses like SARS-CoV-2, making it an essential tool for identifying COVID-19 variants. However, since CRISPR Cas13 is a newly emerged technology in the CRISPR system, there are still some problems that need to be tackled. This article aims to discuss the application of CRISPR Cas13 in treating COVID 19. Two CRISPR Cas13 based diagnostic tools, PAC-MAN and CARMEN, hold potential for detecting variants, with research indicating their ability to degrade viral RNA and suppress viral gene expression. Despite this potential, challenges remain, particularly in achieving efficient and safe delivery systems for Cas13. While it is not yet fully implemented in clinical settings, the progress made so far highlights CRISPR Cas13’s significant role in addressing viral outbreaks, specifically COVID 19 and its potential for future applications in infectious diseases and other RNA-based conditions.
Research Progress of Biosimilars of Monoclonal Antibody Drugs For The Treatment of Tumors
Authors: Qian Jiahao
Published: January 2025

Monoclonal antibodies (mAbs) have gained prominence in cancer treatment due to their targeted therapeutic mechanisms, offering fewer side effects compared to traditional chemotherapy. Despite the advancement in original mAb-based anticancer drugs, the high costs associated with these therapies pose a significant challenge, especially for low- and middle-income countries. This has led to an increased focus on developing biosimilars, which are more affordable alternatives with similar therapeutic effects. This paper reviews the research progress of mAb drugs and their biosimilars for tumor treatment, highlighting the clinical impact of mAbs targeting common cancer markers such as HER-2, CD38, and eEF2K. For instance, trastuzumab biosimilars have been shown to improve the pathological complete response rate (pCR) in breast cancer patients when added to neoadjuvant chemotherapy, demonstrating an approximate 15% increase compared to chemotherapy alone. The study concludes that while biosimilars provide a cost-effective and accessible alternative, there is still a lack of long-term clinical data and real-world efficacy, particularly for biosimilars targeting newer cancer markers like CD38 and eEF2K. The paper highlights key advancements in biosimilar production, such as those of trastuzumab biosimilars, and discusses emerging targets like eEF2K, with potential for future therapeutic interventions.
Advancements in Immunotherapy for Oral Cancer Research
Authors: Zeng Tianyi
Published: January 2025

Oral cancer is one of the common malignant tumors of the head and neck. The survival rate in the late stage is about 50%. At present, more and more immunotherapy is gradually used in the clinical treatment of oral cancer. Some relevant experiments on the efficacy of immunotherapy for the treatment of oral cancer are also actively carried out. However, at present, there is a lack of the latest experimental data on the review of immunotherapy for oral cancer, and the classification method is quite single. This paper divides oral cancer into three stages: prevention, early and late stages, and comprehensively evaluates and analyzes the application effects of immunotherapy at each stage. In particular, based on the KEYNOTE-048 trial data in February 2023, it elaborates on the therapeutic effect of Pembrolizumab in patients with advanced oral cancer. Although there are many types of immunotherapy, some are still only in the theoretical stage and have limited clinical data in oral cancer. At the same time, the treatment boundaries for different stages are still unclear, and clinical applications mainly depend on the patient's immune status and condition. This review aims to provide more valuable reference for further research.
The Application of Imaging and Molecular Markers in Cancer Diagnosis and Treatment
Authors: Wang Teng
Published: January 2025

Cancer is one of the leading causes of death worldwide, and its diagnosis and treatment face many challenges. In recent years, the combination of imaging techniques and molecular markers has made remarkable progress in cancer diagnosis and treatment. Imaging techniques such as CT, MRI and PET-CT can provide anatomical and functional information of tumors, while molecular markers such as EGFR and HER2 play a key role in tumor diagnosis, prognosis and treatment. However, how to effectively combine these technologies to achieve more accurate diagnosis and treatment is still a gap in research. This paper reviews the combined application of imaging technology and molecular markers in cancer diagnosis, therapeutic response monitoring and individualized therapy, analyzes the synergistic effect of multimodal imaging technology and molecular markers, and finds that it has significant advantages in early detection and individualized treatment planning. Combining imaging and molecular marker information can improve the accuracy of cancer diagnosis and guide targeted therapies. The combination of such technologies provides a new reference for precision cancer medicine in the future, but further research is still needed in the aspects of marker sensitivity and image analysis automation. In the future, the combination of new technologies such as artificial intelligence is expected to promote the development of more accurate and efficient cancer diagnosis and treatment.
Studies on the regulation of cellular activity and gene expression under acetaminophen intervention
Authors: Wang Yue
Published: January 2025

This study investigated the effects of acetaminophen on the regulation of cellular activities and gene expression. Through a series of in vitro experiments, the effects of acetaminophen on cell proliferation, apoptosis and metabolism at different doses were analyzed and combined with gene expression profiling to reveal its regulatory mechanisms at the level of signaling pathways, transcription factor regulation and epigenetics. The results indicate that acetaminophen can significantly alter cell physiology and gene expression, suggesting its potential role and risk in drug intervention. This study provides new insights into the clinical application of acetaminophen and provides a theoretical basis for individualized therapy and drug optimization.
Application Progress of Traditional Chinese Medicine as an Adjuvant Therapy for Cardiovascular and Cerebrovascular Diseases
Authors: Ding Shuxiu , Li Ruoqi , Sun Yuxin
Published: January 2025

At present, CVDs are a crucial problem that has puzzled many researchers for a long period. It has a high fatality rate because it will cause many complications and adverse effects on metabolism. Many side effects of pharmaceutical drugs are very serious because the majority of medicine that treat CVDs are western medicines. Pathogenic factors could not be inhibited effectively and the appropriate target spot was not discovered. However, more and more new technologies and drugs have developed and improved in treating this disease. The combination of TCM and WM has profound prospects. Especially in the clinical treatments of CVDs, TCMs play a role as adjunctive drugs by promoting blood circulation and removing blood stasis. And it can be used for reducing the toxic and side effects of chemical medicines. This integrated method not only maintains the traditional theory and drugs such as herbal, animal and mineral materials but also improves therapeutic effects by combining WM and using advanced devices, artificial intelligence and Western dosage forms. These integrative methods can effectively improve the therapeutic effects and reduce the frequency of adverse effects. Scientists made great progress and achievements in this field. However, the specific mechanism of action of the compounds still needs to be explained deeply.