bluuebunny/crossref_metadata_2025 huggingface dataset:
An Early Enriched Experience Drives an Activated Microglial Profile at Site of Corrective Neuroplasticity in Ten-m3 Knock-Out Mice
Authors: Rogerson-Wood Lara , Petersen Justin , Kairouz Abe , Goldsbury Claire S. , Sawatari Atomu , Leamey Catherine A.
Published: December 2022

Environmental enrichment (EE) is beneficial for brain development and function, but our understanding of its capacity to drive circuit repair, the underlying mechanisms, and how this might vary with age remains limited. Ten-m3 knock-out (KO) mice exhibit a dramatic and stereotyped mistargeting of ipsilateral retinal inputs to the thalamus, resulting in visual deficits. We have recently shown a previously unexpected capacity for EE during early postnatal life (from birth for six weeks) to drive the partial elimination of miswired axonal projections, along with a recovery of visually mediated behavior, but the timeline of this repair was unclear. Here, we reveal that with just 3.5 weeks of EE from birth, Ten-m3 KOs exhibit a partial behavioral rescue, accompanied by pruning of the most profoundly miswired retinogeniculate terminals. Analysis suggests that the pruning is underway at this time point, providing an ideal opportunity to probe potential mechanisms. With the shorter EE-period, we found a localized increase in microglial density and activation profile within the identified geniculate region where corrective pruning was observed. No comparable response to EE was found in age-matched wild-type (WT) mice. These findings identify microglia as a potential mechanistic link through which EE drives the elimination of miswired neural circuits during early postnatal development. Activity driven, atypical recruitment of microglia to prune aberrant connectivity and restore function may have important therapeutic implications for neurodevelopmental disorders such as autistic spectrum disorder.
CLASSIFICATION OF COMPANY LIFE CYCLE STAGES: AN AUTOMOTIVE INDUSTRY IN THE CZECH REPUBLIC
Authors: Slavíčková Jana , Slavíček Ondřej
Published: December 2022

Company life cycle models have been the focus of researchers’ attention for decades, resulting in numerous definitions and determination of stages. Managers are striving to make appropriate strategic decisions at the right time to maximize opportunities linked to various life cycle stages. Assessing a company’s life cycle and determining the stage of the cycle allows us to predict a company’s future development and to prevent crises or even the company’s early termination. In recent years, there has been increased interest in the life cycle assessment of products. However, as a corporate life cycle is longer than that of a product, it still definitely deserves attention – mainly in the field of quantitative criteria. The aim of this paper is to propose quantitative variables to determine a company’s life cycle following two requirements: (1) the variables are derived from publicly available financial statements; and (2) the classification method is suitable for a large sample size including non-listed companies in the stock exchange. Our study shows that our three variables (capital expenditures, return on equity, and sales growth) are suitable for stage classification for each firm-year under the condition of following several steps: counting industry quintiles and/or definition of boundaries, score assignment to stages, designing composite score and sample selection. Based on descriptive statistics of each life cycle stage it is possible to assess the variables used in the context of the further strategic direction of the company. To determine the persistence of enterprises in the defined stages, a transition matrix for the four future years was performed, which showed that companies in the growth and maturity stages will be sustained in these two phases in the vast majority of cases. Finally, we discuss the limitations of the study and further research directions.
EXAMINING TREKKERS’ ENVIRONMENTALLY FRIENDLY BEHAVIOR USING AN EXTENDED MODEL OF GOAL-DIRECTED BEHAVIOR (MGB) AND A NEW ECOLOGICAL PARADIGM SCALE (NEP)
Authors: Tulsi Paudel , Li Wen Ya , Kim Yeong Gug
Published: December 2022

Tourism has a substantial environmental impact, and nature-based tourism is particularly vulnerable to tourists’ activities. Individuals must be aware of the consequential ecological effects during nature-based tourism activities such as trekking. Trekking is a widespread nature-based tourism activity in fragile mountainous and hilly regions. The trekkers’ activities extensively affect the conservation of vegetation along the trail. Therefore, it is essential to study trekkers’ attitudes, intentions, and behavior towards the environment. The objective of this study is to investigate the pro-environmental behaviors of trekkers. The goal-directed behavior (MGB) model framework and a new ecological paradigm scale (NEP) were integrated to examine trekkers’ environmental decision-making process. The new ecological paradigm (NEP) scale measured trekkers’ environmental concerns, whereas the model of goal-directed behavior (MGB) explored environmentally friendly trekking intentions. The extended model analyzed 310 responses from trekkers who had trekking experience in Nepal. Statistical analyses, such as confirmatory factor analysis, descriptive analysis, reliability, and validity test, were performed with SPSS 24.0. Furthermore, structural equation modeling was conducted using AMOS 22.0 to test the significance of the developed hypotheses. This study revealed that trekkers are concerned about the environment and are aware of the earth’s resource limitations. Moreover, the significant role of emotion in the decision-making process was identified. The perceived behavioral control influenced both the desire and intention of environmentally friendly trekking. Additionally, desire significantly influenced the intention to perform environmentally friendly activities. However, the trekker’s attitude and subjective norms did not correlate substantially with desire. The obtained results indicate that the proposed extended model helps to understand the environmental behavior of trekkers. The theoretical and practical implications of this study are also discussed.
THE IMPACT OF THE COVID-19 PANDEMIC ON ONLINE CONSUMER BEHAVIOR FOR THE BOOK MARKET IN ROMANIA
Authors: Dincă Violeta Mihaela , Dima Alina Mihaela
Published: December 2022

The COVID-19 pandemic and the subsequent lockdown, along with the social distancing rules imposed by governments around the world, have caused major changes in the publishing industry and, therefore, in the book consumption patterns. The main goal of this paper is to identify the changes in the purchasing habits of book consumers within two different frameworks of motivations: utilitarian and hedonic – both studied during the COVID-19 pandemic. A model was developed to study the effects of the COVID-19 pandemic as a circumstantial impact, because it implicated the temporary shutdown of physical bookshops, the uncertainty of contracting the virus by visiting the shops once they re-opened along with the upgrades that online bookshops developed during the pandemic to attract customers. Data were gathered from 410 Romanian consumers by applying an online survey. Multivariate data analysis applied to the model showed that the COVID-19 pandemic context had a positive and significant influence on the customers’ intents of online book purchasing. Moreover, while hedonic reasons exerted a compelling influence on the customers’ intents to buy books online, the association between utilitarian reasons and online buying intents is positive, but insignificant. These results could support all stakeholders within the book market, such as publishing firms and online bookshops to strengthen their online presence – to develop their websites, their social media pages, as well as expand their advertising operations through different channels. The outcomes of this research are important and useful also for the academic environment, as the changes within the book market and the evolution of book consumption behavior influence research and academic writing overall.
Host‐derived O‐glycans inhibit toxigenic conversion by a virulence‐encoding phage in Vibrio cholerae
Authors: Wang Benjamin X , Takagi Julie , McShane Abigail , Park Jin Hwan , Aoki Kazuhiro , Griffin Catherine , Teschler Jennifer , Kitts Giordan , Minzer Giulietta , Tiemeyer Michael , Hevey Rachel , Yildiz Fitnat , Ribbeck Katharina
Published: December 2022

Pandemic and endemic strains of Vibrio cholerae arise from toxigenic conversion by the CTXφ bacteriophage, a process by which CTXφ infects nontoxigenic strains of V. cholerae. CTXφ encodes the cholera toxin, an enterotoxin responsible for the watery diarrhea associated with cholera infections. Despite the critical role of CTXφ during infections, signals that affect CTXφ‐driven toxigenic conversion or expression of the CTXφ‐encoded cholera toxin remain poorly characterized, particularly in the context of the gut mucosa. Here, we identify mucin polymers as potent regulators of CTXφ‐driven pathogenicity in V. cholerae. Our results indicate that mucin‐associated O‐glycans block toxigenic conversion by CTXφ and suppress the expression of CTXφ‐related virulence factors, including the toxin co‐regulated pilus and cholera toxin, by interfering with the TcpP/ToxR/ToxT virulence pathway. By synthesizing individual mucin glycan structures de novo, we identify the Core 2 motif as the critical structure governing this virulence attenuation. Overall, our results highlight a novel mechanism by which mucins and their associated O‐glycan structures affect CTXφ‐mediated evolution and pathogenicity of V. cholerae, underscoring the potential regulatory power housed within mucus.
Validación de un cuestionario web sobre actividad física para niños y adolescentes
Authors: Legnani R.F.S. , Legnani E. , Pereira da Silva M. , Cordeiro Barbosa Filho V. , Gustave E.L.D. , Campos W.
Published: December 2022

El objetivo del estudio fue llevar a cabo la validez concurrente del cuestionario WebCas para evaluar la actividad física (AF) en 140 estudiantes (10 a 16 años) divididos en cuatro grupos, instruidos para usar un acelerómetro y contestar el cuestionario WebCas diariamente, resultó en 213 días de monitoreo de AF. Los análisis estadísticos se realizaron utilizando la prueba U de Mann-Whitney, gráficos de dispersión (Bland y Altmann) y coeficientes de correlación. La correlación entre las mediciones de AF (WebCas) en comparación con las mediciones de acelerometria (un día) mostró correlación de baja intensidad (r = 0.22; p <0.001), moderado intensidad (r = 0,48; p <0,04), promedio de los tres días. Se observó mayor correlación para el promedio de AF de los 5 días (r = 0,67; p <0,01). El cuestionario WebCas presentó indicadores de validez satisfactorios.
Desempeño de competencia matemática en contextos de la Educación Física en primaria
Authors: Rodríguez-Martín B. , Buscà Donet F.
Published: December 2022

El objetivo de la investigación fue valorar en qué grado el recurso didáctico diseñado en el marco de la Educación Física de 4º de Primaria impulsaba el desempeño de la Competencia Matemática. La intervención didáctica estaba conformada por situaciones-problema contextualizadas en entornos de Educación Física. 68 estudiantes, a través del trabajo cooperativo tenían el reto de elaborar e implementar un plan en el que utilizando sus conocimientos matemáticos resolvieran las situaciones planteadas. Se diseñó un estudio de casos cuyos resultados fueron de naturaleza cuantitativa-cualitativa. Se recogieron datos mediante la observación participante, notas de campo, cuestionarios y entrevistas. Los resultados mostraron que el alumnado ejecutó habilidades matemáticas competenciales en niveles de desempeño medio-alto. Refuerzan estas evidencias de aprendizaje que el alumnado reconociera los contenidos matemáticos aprendidos y el papel de las matemáticas en la Educación Física. Además, el profesorado de matemáticas observó un dominio de contenidos no trabajados en el aula.
Efectos del COVID-19 en la carga externa en el fútbol de alto nivel
Authors: Ramos Verde E.J. , García Manso J.M. , Díaz Díaz R.
Published: December 2022

Analizamos el efecto del cese de la competición por COVID-19 en el rendimiento físico de jugadores de fútbol de la 1ª división española). La muestra se estratificó en tres grupos: rondas 1ª-3ª; 25ª-27ª y 28ª-30ª. Las comparaciones por pares fueron Student-t y Mann-Whitney U. Usamos un valor p de ?0.05 como criterio para la significación estadística. Los valores de umbral para evaluar las magnitudes del tamaño del efecto se realizaron a través (d de Cohen). Tras el parón, las distancias recorridas aumentaron en los equipos locales y visitantes. Hubo un ligero descenso de los esfuerzos de alta intensidad entre el post-confinamiento y las jornadas (25ª-27ª). Comparados el 1er y 3er periodo, los valores fueron ligeramente superiores (rondas 28ª-30ª). Eso mismo se observó en las de aceleraciones y desaceleraciones, con mayores diferencias entre los periodos (1º y 3º). Hubo diferencias, cuando se comparó la reanudación con las jornadas previas al parón.
Risk Factors of Chronic Kidney Disease after Partial Nephrectomy
Authors: Makevičius Jurijus , Kirstukaitė Beata , Komiagienė Renata , Želvys Arūnas , Jankevičius Feliksas , Miglinas Marius
Published: December 2022

Background: In comparison with radical nephrectomy, partial nephrectomy (PN) is considered a better option for small renal mass surgery, because of optimal kidney tissue removal and parenchyma preservation. But there are patients with worsening postoperative renal function (RF) and chronic kidney disease (CKD) after PN. Therefore, the study aimed to evaluate and detect risk factors for CKD after PN.Materials and Methods. A prospective observational study was conducted, which consisted of 91 individuals who received PN with warm ischemia and an estimated preoperative glomerular filtration rate (eGFR) ≥ 60 ml/min/1.72m2 without pathologic albuminuria. Preoperative and intraoperative factors like intraoperative hypotension (IOH), blood loss, and resected part volume were analyzed.Results. At 6-month follow-up, 14 (15.4 %) patients experienced postoperative CKD. After 12 months of follow-up, 15 (16.5 %) patients had CKD. Patients with CKD had a lower preoperative eGFR than non-CKD group (69.0 vs 91.0 ml/min/1.72m2, p < 0.001), longer ischemia (20.0 vs 14.0, p = 0.002) and IOH time (40.0 (40.0; 47.5) vs 0.0 (0.0; 26.2) min, p < 0.001). Also, higher volumes of resected kidney part tumor and removed parenchyma with higher glomerulosclerosis amounts (73.3 % vs 14.5 %, p = 0.009) were found in CKD group. Estimated blood loss > 500 ml during PN was discovered to be the major risk factor for CKD development (OR 11.13, 95 % CI 1.88–65.92, p = 0.008). Furthermore, kidney resected part volume (OR 1.05, 95% CI 1.05-1.10, p = 0.033) and IOH time (OR 1.11, 95% CI 1.03-1.19, p = 0.005) were identified as risk factors for postoperative CKD. Conclusions. Patients after PN are at an increased risk of CKD development. Most commonly, postoperative CKD occurs in the first 6 months after PN and appears stable after 12 months of follow-up. Blood loss > 500 ml during PN, IOH and resected kidney volume can have an impact on postoperative RF and increase the risk of CKD.
Novel arsenic resistant bacterium Sporosarcina luteola M10 having potential bioremediation properties
Authors: Salam Menaka , Varma Ajit , Chaudhary Divya , Aggarwal Himanshi
Published: December 2022

Arsenic (As) is a highly toxic element with great mobility in the environment. If present in high concentrations in soil as well as groundwater, it poses a threat to all living organisms. Although there are many remedial methods which mostly rely on adsorption and filtration, novel technologies using microorganisms are of great attention due to their efficient degradation properties and cost-effectiveness. The present study emphasizes on novel arsenic resistant bacterium which has been isolated from electronic waste contaminated soil samples of Mandoli area in Delhi NCR, India. The isolated bacterium, identified as Sporosarcina luteola through 16S rRNA gene sequencing is tolerant to high levels of arsenic oxyanions. This bacterium designated as Sporosarcina luteola M10 could tolerate arsenate (V) upto 0.2M and arsenite (III) upto 0.01M in minimal medium. The arsenic removal efficiency was 60% of arsenate and 55.5% of arsenite respectively from arsenic amended media at 72 h as detected by atomic absorption spectroscopy. arsC, arsB and aoxB genes encoding arsenate reductase of 280 bp, arsenite transporter of 750 bp and arsenite oxidase of 450 bp respectively were found to be present through PCR amplification of genomic DNA. This is the first report of Sporosarcina luteola extremely resistant to arsenic having potential bioremediation properties.
About perspectives for the development of school medicine in Ukraine
Authors:   Kharkiv Medical Academy of Postgraduate Education, Strashok L.A. , Danilenko G.M. ,   SI «Institute of Children and Adolescents Health Care of the NAMS of Ukraine», Zavelya E.M. ,   Kharkiv Medical Academy of Postgraduate Education, Isakova M.Y. ,   Kharkiv Medical Academy of Postgraduate Education, Yeshchenko A.V. ,   Kharkiv Medical Academy of Postgraduate Education
Published: December 2022

The article presents the history of the development of school medicine in Ukraine, the birth of national school hygiene as an independent science. It was emphasized that school medical services are very important both in maintaining the health of the younger generation and in providing the best conditions for its formation, health promotion, and prevention of pathological conditions. In 1922–1935, institutes of health care for children and adolescents and institutes for the protection of motherhood and childhood were opened in Ukraine for the scientific development of health care issues for schoolchildren and adolescents. In October 1922, the first Ukrainian State Institute for Maternal and Child Health was opened in Kharkiv, which is now called SI «Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine». The Institute has become a leading research institution in Ukraine, which coordinates research on «Health Care of schoolchildren and adolescents», trains highly qualified personnel, publishes methodological and informational materials for implementation in practice, conducts scientific and practical conferences, and scientific symposiums on topical issues, including school medicine. According to the Resolution of the Cabinet of Ministers of Ukraine № 31 of January 20, 2021 «On approval of the Procedure for providing medical care to students of general secondary education» medical care for students is now provided by a medical worker who is a member of the educational institution. Ways to improve the organization of medical care for students in secondary schools for more effective development of school medicine, the expediency of using the resources of the SI «Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine» are presented. Therefore, only the combined work of educational and health care institutions can provide the most favorable conditions for maintaining the health of students.
«Military-Surgical notes from the Serbian-Turkish war of 1876» as a reflection of Аpollinarius Podrez’s early professional development
Authors:   Kharkiv National Medical University, Robak І.Yu. , Alkov V.A. ,   Kharkiv National Medical University
Published: December 2022

To honor memory of outstanding Ukrainian surgeon-innovator A. G. Podrez in the connection with his 170th anniversary, authors analysed his “Military-Surgical notes from the Serbian-Turkish war of 1876”. The conclusion has been done that the medic gained significant experience not only in field surgery, but also in all the spheres of medical institution functioning in extremal conditions, and it gave a powerful impetus for professional development.
Physical rehabilitation and recovery in neurological diseases
Authors:   Ukrainian Institute of Arts and Sciences, Livak P.E. , Korchuk O.S. ,   Ukrainian Institute of Arts and Sciences, Kozhukh N.P. ,   Ukrainian Institute of Arts and Sciences
Published: December 2022

The author proved that the problem of neurological diseases is relevant despite the high development of medicine, because in conditions of stress, constant fatigue and poor ecology, we see the growth of patients with nervous disorders. Every year, more and more people of all ages turn to doctors with symptoms that indicate complex neurological diseases. Neurology includes a large number of diseases that can occur after viral diseases or due to improper lifestyle. The most common neurological diseases that cause a large number of deaths in Ukraine are Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Some neurological diseases are more treatable and easier to tolerate, the progression and development of which can be stopped, while others are severe, which official medicine defines as incurable and lead to disability. It is important to seek the help of a specialist in time to correctly diagnose the disease and avoid unforeseen complications. For each patient it is necessary to select an individual treatment program that depends on the severity of the disease and diagnosis. Today, such a complex and currently incurable neurological disease as multiple sclerosis is becoming more common. This is a chronic autoimmune disease in which the myelin sheath of the nerve fibers of the brain and spinal cord is damaged and thus the functioning of the nervous system is disrupted. Today, this disease is one of the leading causes of disability in young patients. Occurs for unknown reasons and is constantly progressing, leading to serious physical changes and disability. The author argues that physical rehabilitation is a natural and extremely effective method of treating neurological diseases, including multiple sclerosis.
Neurological complications of SARS-CoV-2 infection
Authors:   Katedra Fizjologii Zwierząt i Człowieka, Wydział Biologii, Uniwersytet Gdański, Gdańsk, Polska, Sawicka Aleksandra ,   Zakład Neuropatologii, Instytut Psychiatrii i Neurologii, Warszawa, Polska, Acewicz Albert ,   Zakład Neuropatologii, Instytut Psychiatrii i Neurologii, Warszawa, Polska
Published: December 2022

SARS-CoV-2 virus was first identified in 2019 in Wuhan (China) and is responsible for the ongoing COVID-19 pandemic. Although the virus causes mild, transient symptoms of an upper respiratory tract infection in most cases, it can also lead to severe pneumonia, respiratory failure and/or death. Approximately 85% of patients experience central and peripheral neurological symptoms. In the acute phase of the disease, ischaemic strokes, intracranial haemorrhages, meningitis and encephalitis, acute demyelinating diseases and acute inflammatory polyneuropathies may occur. However, mild neurological symptoms that can persist for months and significantly affect daily functioning are much more common. These include headache and dizziness, olfactory and gustatory dysfunction, mild cognitive disturbances, as well as depressive, anxiety, and sleep disorders. Some of them are encompassed by popular terms “post-covid syndrome” and “brain fog.” The pathogenesis of neurological complications of SARS-CoV-2 infection is still not fully understood; overproduction of cytokines induced by viral infection may be of great importance. There is no causal treatment, while symptomatic treatment is of limited effectiveness. Primary prevention in the form of SARS-CoV-2 vaccinations is of great importance. In the following review, we would like to present the current knowledge on epidemiology, pathology, pathogenesis and treatment of neurological complications after SARS-CoV-2 infection. Further multi-centre, large-scale clinical studies are necessary to identify the exact pathogenetic mechanisms.
Summary of bathythermograph observations from the western North Atlantic : October 1940 - December 1941
Authors: Iselin Columbus O'Donnell
Published: December 2022

The range of submarine detection is frequently limited by the refraction produced by vertical temperature gradients in the superficial layers of the ocean. In order to measure these temperature gradients and thus to permit predictions of the range, the bathythermograph was developed and is now being used on a considerable number of anti-submarine vessels, while a somewhat modified version of the instrument is being tried out on submarines. Some 6675 bathythermograph observations from the western North Atlantic have been examined in order to determine how frequently such observations should be made so that within practical limits and anti-submarine vessel may at all times know the assured range of its sound gear. The occurrence of the four basic types of refraction patterns is shown by a series of six charts. For all but one of these patterns the range can be rather quickly and easily estimated from simple tables; but when the so-called afternoon effect is encountered, which is on the average about 20% of the time, a more complete analysis is necessary. It is found that under the most unfavorable circumstances, that is, in mid-summer and near the edges of a strong current system, there is about one chance in three that the refraction pattern will chance significantly in a distance of four miles. At other times of year and in areas where horizontal variations in temperature are less pronounced a single bathythermograph observation can be considered representative of a much larger area. It is also shown that in the western North Atlantic about 92% of the time in summer and about 34% of the time in winter the assured range of submarine detection is limited by refraction to less than 2500 yards.
PRÁCTICA Y METODOLOGÍA DE CO-LABOR EN LAS ORGANIZACIONES; LA COMUNALIDAD EN LA RED DE HUERTOS EDUCATIVOS Y COMUNITARIOS DE XALAPA (MÉXICO)
Authors: Pabello Giovanna Mazzotti , Nasupcialy Kay Nicte Nava
Published: December 2022

RESUMEN En este artículo se presenta el proceso discursivo que precisa la definición de categorías interpretativas de una investigación realizada desde una metodología de co-labor en el marco de la transmodernidad organizacional. A partir de ello, se pone a debate la universalidad de los principios de la productividad y la eficiencia como orientadores que dan sentido a la organización moderna, a la vez que se sostiene la existencia de ejes articuladores propios de los colectivos autogestivos. Para ello se aborda la experiencia de la Red de Huertos Educativos y Comunitarios de Xalapa, Veracruz, México, la cual se organiza como comunidad afectiva a partir de principios comunales del organizarse desde el territorio con las y los otros y para las y los otros.
LOS DEBATES ACADÉMICOS SOBRE EL ESTADO Y LA ADMINISTRACIÓN PÚBLICA Y EL TIPO DE ESTADO PREDOMINANTE EN ARGENTINA (1990-2018)
Authors: Mansilla Gabriela
Published: December 2022

RESUMEN La presente propuesta – fundamentalmente de carácter descriptivo – tiene como objetivo reflexionar acerca de las vinculaciones entre la tendencia de los debates académicos en Argentina y en el período 1990-2018; y el tipo de Estado predominante. Para ello, en primera instancia, se caracterizarán las orientaciones temáticas (burocracia, reforma del Estado y administrativa, fiscalidad estatal, políticas públicas, regulación y control de los servicios públicos, empresas públicas, entre otros) que han tenido las discusiones y debates sobre el Estado y la administración pública en el ámbito académico en Argentina en el período mencionado. Período que se ha caracterizado por diferentes tipos de Estado: primero, el Estado neoliberal y posteriormente, el Estado neodesarrollista e intervencionista en lo económico y social, conectados por un Estado considerado transicional como el que se extendió entre 2001 y 2003. Para el logro de este objetivo, se relevaron y clasificaron trabajos académicos de diversas bases de datos correspondientes a revistas científicas del campo de la Ciencia Política y la Administración Pública; bibliotecas especializadas; y ponencias presentadas en congresos de la especialidad.
REAL OPTIONS THEORY AND CLASSIFICATION OF PATIENTS BY DIAGNOSIS RELATED GROUPS: HOW THESE DIFFERENT FIELDS COULD RELATE?
Authors: Rocha Milena de Cássia , Gonçalves Márcio Augusto , Lawryshyn Yuri
Published: December 2022

ABSTRACT In a complex environment, the managers of hospital organizations should take hard decisions all the time. Therefore, tools and techniques, which seek to understand the past and project the future, are very important. In some situations, the complexity encountered requires the transfer of knowledge from other areas, to find solutions and develop tools that provide efficient management of resources. In this scenario, this article has the main objective to present a theoretical discussion that brings the relationship between the Theory of Real Options and the Diagnosis Related Groups, to identify possible points that underlie the use of real options in Diagnosis Related Groups. The results demonstrate that, with the patient's condition as the focus, both are applied in the hospital environment with the objective of supporting decision-making, but not together. In addition, the differences observed make the combination of some of its concepts relevant for decision-making.
Um laboratório da Fundação Rockefeller: interação médica e produção de conhecimento científico na saúde internacional
Authors: Batista Ricardo dos Santos
Published: December 2022

Resumo: O presente artigo analisa a recepção do Laboratório da Fundação Rockefeller na Bahia, entre 1928 e 1930, como propulsor de interações entre agentes de saúde e agentes de construção de conhecimento científico. São utilizados como fontes relatórios, textos diversos, diários e correspondências de profissionais que atuaram na pesquisa e no controle da febre amarela, além do periódico soteropolitano A Tarde. Conclui-se que a presença do laboratório foi de fundamental importância para a produção e interpretação de dados sobre mosquitos, amarílica e malária em Salvador e em cidades do interior da Bahia. As pesquisas desenvolvidas naquele espaço foram publicadas como contribuição valiosa para a compreensão de aspectos da febre amarela e, eventualmente, apresentadas em eventos nacionais, a exemplo do V Congresso Brasileiro de Higiene. Além disso, foi possível observar desconfianças e conflitos de interesses entre brasileiros e norte-americanos ao longo da atuação da agência internacional no Estado da Bahia.
O projeto da parteira Madame Durocher sobre a emancipação dos escravos na crise do Império brasileiro
Authors: Ribeiro Júnior Florisvaldo Paulo
Published: December 2022

Resumo Madame Durocher, uma famosa parteira que viveu na cidade do Rio de Janeiro, escreveu e publicou, na década de 1870, um opúsculo em que abordava a problemática da emancipação dos escravos. Neste texto, resultado de uma pesquisa mais substancial, procurei analisar esse documento, tentando colocá-lo em uma perspectiva mais ampla que envolvesse o debate político que desde meados da década de 1860 se dedicou a construir soluções que visassem a extinção da escravidão. Procurei assinalar, também, as peculiaridades profissionais e políticas de Madame Durocher, mostrando suas posições políticas conservadoras e sua movimentação pela Corte Imperial contrariando o ordenamento social prescrito. Por fim, tentei destacar o enraizamento das posições conservadoras quanto à abolição da escravidão e à emergência de uma “política racial” representadas no seu escrito.
Sérgio Buarque de Holanda em combates com Alceu Amoroso Lima: o tomismo na tópica do atraso
Authors: Sanches Dalton
Published: December 2022

RESUMO Consideravelmente exíguos na vasta fortuna crítica dedicada aos autores, este trabalho se concentra na interlocução cerrada e exaustiva entre Sérgio Buarque de Holanda e Alceu Amoroso Lima. Ao propormos uma leitura contrastiva de escritos dos dois intelectuais entre as décadas de 1920 e 1940, como cartas, artigos de jornal e as suas publicações em livros, apresentaremos a recorrência da crítica - ora cifrada, ora explícita - de Buarque de Holanda à concepção tomista de Amoroso Lima. A julgar pelas impressões do primeiro, tal concepção orienta as várias instâncias da vida do segundo, em níveis estético, epistemológico, político, econômico e social. Partindo da - e retornando, ao final, à - análise pontual de algumas modificações efetuadas por Sérgio Buarque ao longo das duas primeiras edições de Raízes do Brasil (1936-1948), reconstituiremos a historicidade das estratégias e das formas com que o pensamento do católico - de viés conservador, até então -, desde os tempos das celeumas modernistas, é inscrito no combate e condensa semanticamente um conjunto de significantes confluentes à tópica do atraso; especialmente se pensarmos que o livro de estreia do historiador, a partir da edição de 1948, acentuadamente, se insere no paradigma da formação, dotando-o substancialmente de um caráter político progressista ainda não previsto na edição de 1936.
Conjuntos e comunidades autóctones andinas altiplânicas na cidade de São Paulo: panoramas temporais e espaciais
Authors: Branco Cristina de
Published: December 2022

Resumo. Hoje em dia, pela cidade de São Paulo, centenas de pessoas vindas do Altiplano andino se expressam através de seus grupos de música e dança de referência autóctone. Em certas alturas do ano, no Canindé e na Vila Guilherme, pelas zonas norte e sul da capital, se escutam instrumentos de vento e bombos tocados sobretudo por conjuntos de homens, geralmente seguidos ou rodeados por mulheres que dançam ao compás desses sopros. Fundados por pessoas nascidas em território (hoje) boliviano ou peruano e dinamizados também por seus filhos já nascidos no Brasil, estes grupos diversificam os retratos bolivianos e peruanos na cidade. A partir da observação participante, da realização de entrevistas e vídeos com integrantes desses conjuntos e comunidades desde 2015, este artigo trará panoramas referenciais histórico, geográfico e estilístico que pretendem dar conta de nomear os grupos formalizados e ativos hoje em dia, relacionando-os a nível cronológico, espacial e performático.
Transnational Migration and Reconfiguration of the Family in Zimbabwe
Authors: Jaji Rose
Published: December 2022

Abstract The unprecedented transnational migration ensuing from the economic crisis in Zimbabwe has sociocultural impacts on both migrant and non-migrant family members. This article, which draws from qualitative research with migrants and non-migrants, discusses how migration upsets cultural configurations of the family in terms of marriage, parenthood, childhood, the gender and age division of labor, and family relations. Transnational migration has destabilized traditional family structures by creating relations and gender roles that challenge cultural and social values relating to both the nuclear and extended families. Transnational migration has also transformed the family’s place in the migrant’s life and vice versa in ways that deviate from the cultural norm.
Peças de comunicação governamentais sobre as profilaxias pré (PrEP) e pós-exposição (PEP) ao HIV (2016-2019): análise de seus conteúdos e circulação entre gays, mulheres trans/travestis e trabalhadoras sexuais
Authors: Mora Claudia , Nelvo Romário , Monteiro Simone
Published: December 2022

Resumo Este artigo analisa a divulgação das profilaxias pré (PrEP) e pós-exposição (PEP) ao HIV, considerando o papel histórico das campanhas de prevenção à aids. São utilizadas 24 peças de comunicação sobre PrEP, PEP e PC (Prevenção Combinada), produzidas entre 2016 e 2019 e publicadas no site e mídias sociais do Ministério da Saúde, e o depoimento de 30 usuários(as) das profilaxias - que incluem gays, mulheres trans/travestis e profissionais do sexo - na região metropolitana do Rio de Janeiro. As peças foram classificadas quanto ao tipo, ano, público e informação de acesso, e os resultados foram interpretados a partir de três eixos: sexualidade e risco; gênero, emoções e moralidades; deslocamentos do preservativo. A análise indicou o apagamento das expressões de sexualidade e o predomínio de uma linguagem abstrata e esquemática, pressupondo um público racional e individualista, com o preservativo associado à ideia de “risco sexual”. Os relatos dos(as) usuários(as) quanto à divulgação de informações sobre essas profilaxias evidenciaram sua insuficiência. Concluímos que ocorre uma baixa exploração do potencial das campanhas de comunicação, orientadas pela realidade sociocultural dos segmentos sociais, comprometendo o acesso às profilaxias. Assim, a biomedicalização da prevenção e o avanço do conservadorismo prejudicam a resposta brasileira à aids.
Investigation of Parametric, Non-Parametric and Semiparametric Methods in Regression Analysis
Authors: YAVUZ Esra , ŞAHİN Mustafa
Published: December 2022

Regression analysis is known as statistical methods applied to model and analyze the relationship between variables. Regression method can be examined as parametric, non-parametric and semiparametric regression methods.

The parametric regression method assumes that the dependent variable is in a linear relationship with the independent variables and that the shape of the relationship is known. If these assumptions are not met, non-parametric regression methods are applied. However, these methods cause difficulties especially in the interpretation part due to the problem of multidimensionality when there is more than one independent variable. Thus, when there is more than one independent variable, some of the independent variables may be in a linear relationship with the dependent variable, while the other part may be in a nonlinear relationship. Thus, in order to model these relationships, semiparametric regression methods, which are the additive combination of parametric and non-parametric regression methods, are used.

In this study, parametric regression method, definition of non-parametric regression method and assumption conditions are given. It has been shown that the semiparametric regression method can be applied in cases where these assumptions are not met. Thus, in the study, regression methods were examined in three different parts, and parametric, non-parametric and semiparametric regression methods were examined theoretically.
Production benefits recall of novel words with frequent, but not infrequent sound patterns
Authors: López Assef Belén , Strahm Stephanie , Boyce Keara , Page Mike , Zamuner Tania
Published: December 2022

The production effect is influenced by various factors, including cognitive and linguistic-related variables. Previous studies found that the production effect varies when stimuli have native versus non-native speech sounds, but to date, no studies have investigated whether the effect is also modulated by the frequency of sound patterns within a language. Adults were taught novel words in two training conditions: Produced or Heard. These items were comprised of English sound patterns that varied in frequency. Participants trained on frequent English patterns recalled more Produced than Heard items. In contrast, participants trained on infrequent English patterns showed no difference in recall rates between conditions. The strength and direction of the production effect is modulated not only by native versus non-native speech sounds, but can also vary depending on the frequency of the sound patterns within a speaker’s native language. Thus, the production effect is linked to previously established, long-term phonological knowledge.
The Permanent Struggle for Racial Justice in the USA: Interpreting Derrick Bell’s »The Space Traders«
Authors: Lee-Price Simon
Published: December 2022

Dieser Beitrag behandelt die erstmals 1989 veröffentlichte und seither kontrovers diskutierte SF-Kurzgeschichte »The Space Traders« des Wissenschaftsaktivisten und critical-race-Theoretikers Derrick Bell. In der Kurzgeschichte stimmt die weiße amerikanische Mehrheitsgesellschaft dafür, die afroamerikanische Bevölkerung im Tausch gegen finanzielle Mittel und fortgeschrittene Technologien an außerirdische Lebewesen auszuliefern. Der Beitrag diskutiert die Entwicklung des Werkes, das zunächst als pädagogischer Text im Rahmen juristischer Lern- und Lehrkontexte zur Anregung von Diskussionen sowie der Ausbildung eines rassismuskritischen Bewusstseins genutzt wurde. Ebenso wird seine Bedeutung als Teil von Bells mehrschichtiger fiktionaler Welt aus dialogischen Texten analysiert sowie auch der Einsatz von SF-Konventionen und genrespezifischen literarischen Mitteln. Der Artikel argumentiert, dass »Space Traders« einen Beitrag zur gegenwärtigen Diskussion über die Folgen der Sklaverei und den Kampf gegen ethnisch bedingte Ungleichheit leistet, indem das Werk die Geschichte von Rassismus im Hier und Jetzt verankert. So etabliert die Kurzgeschichte eine Art des Widerstands, die, basierend auf Bells aktivistischer Handlungsethik, einen fortwährenden dialogischen Austausch hervorhebt.
Analysis of consensus map of Memorable Tourism Experience (MTE): An application of Zaltman’s Metaphor Elicitation Technique (ZMET) method
Authors:   The Tourism Sciences Society Of Korea, Han Gwan-Hui , Lee Gye-Hee
Published: December 2022

In an increasingly competitive tourism market, creating long-lasting tourism experiences is critical. In this study, we use Zaltman's Metaphor Extraction Technique (ZMET), one of the visual qualitative research methods, to discover the essence of tourist experiences that tourists have long remembered and to find the universal thought structure shared by tourist groups as a shared conceptual diagram. ZMET believes that most human communication is nonverbal, and that figurative thinking is primarily expressed through images rather than language. In this study, ZMET, an effective methodology for identifying and surfacing invisible empirical thoughts, emotions, thoughts, and motives, was used to analyze the relationship between the constituent concepts and sub-components based on the memorable tourism experience and to determine the common value and final purpose of tourists. As a result, the concept commonly recognized by the tourist group was 1) Self examination and Self-finding 2) Novelty and Heterogeneity 3) Interaction with locals 4) Interaction with companion 5) Natural scenery 6) Serendipity 7) Locality 8) Escape from daily life 9) Healing 10) New knowledge and learning. Based on the findings of this study, it is important to broaden the academic base of the tourism field by developing a shared concept map shared by tourists and using it as basic data for marketing strategies and efficient decision-making, such as the planning and development of tourism contents and products.
The burden of road traffic accident-related trauma to orthopaedic healthcare and resource utilisation at a South African tertiary hospital: a cost analysis study
Authors: Thikhathali N , Ngcelwane M
Published: December 2022

BACKGROUND: Road traffic accidents (RTAs), the second commonest cause of trauma in South Africa (SA), are on the rise. It is therefore important to study and understand the burden of RTA-related injuries on our orthopaedic healthcare and healthcare in general, in order to devise new prevention strategies to minimise the number of RTAs METHODS: A retrospective analysis of data from orthopaedic trauma intake records was done for patients admitted with RTA-related injuries to the orthopaedic department at a South African tertiary hospital between February 2019 and January 2020. Hospital records and the PAC (picture archiving and communication) system were analysed for radiological studies done. The Uniform Patient Fee Schedule (UPFS) was analysed for individual costing of all variables being studied RESULTS: There were 642 patients seen and managed with RTA-related injuries included in this study. Seventy-one per cent of them were males, with an average age of 35 years. The majority (76.2%) were motor vehicle occupants, whereas 17% were pedestrians. Seventeen per cent of them had polytrauma. Four hundred and sixty-two (76%) patients required some form of surgical intervention and spent an average of 171 minutes in theatre per procedure. Ten per cent of these patients required ICU/HCU admission for an average of 13 days. The total length of hospital stay was an average of 21.8 days. The majority of patients (67%) had some form of orthopaedic implant inserted, with an average of 1.3 implants per patient. The average cost per patient was R92 737.39. The major cost drivers were hospital stay, ICU/HCU stay, implant cost, radiological studies and theatre utilisation, respectively CONCLUSION: Management of RTA-related trauma puts a significant burden on orthopaedic healthcare management and resource utilisation. While we may not be able to directly influence other contributing factors to high costs, reducing the use of temporary external fixators may help reduce the cost of managing RTA victims These findings provide scientific data which will help support the implementation of preventative measures aimed at minimising the numbers of RTAs we see on our roads, thereby minimising the burden this puts on our healthcare system. Level of evidence: Level 3
16S_PCR_Sequence_Analysis v1
Authors: Acosta Kenneth
Published: December 2022

Protocol to generate a consensus 16S rRNA gene sequence from forward and reverse sequences.
Synthesis of double-strand cDNA (ds-cDNA) from viral dsRNA by using Random primers v1
Authors: Jalali Javaran Vahid
Published: December 2022

Double-stranded cDNA synthesis from viral dsRNAs: For dsRNA sequencing by nanopore sequencing, this protocol was used. Before treating samples with RNase T1, you should measure the total concentration of RNAs in the samples by using a nanodrop or Qubit device, as RNase T1 has the ability to partially digest double-stranded RNAs in the absence of single-stranded RNA.
Protocol forCross-species characterization in the reproduction of Spodoptera sunia (Lepidoptera: Noctuidae) v2
Authors: Ivan Real Baca Carlos
Published: December 2022

The Protocol describes the process for Cross-species Characterization in the reproduction of Spodoptera Sunia(Lepidoptera: Noctuidae). With the characterization it was possible to evaluate the reproductive biological parameters of the species Spodoptera sunia.
Adverse Events After Receipt of an Inactive Coronavirus Disease-19 Vaccine in Healthcare Professionals: A Cross-Sectional Study
Authors: BEKİROĞLU ERGÜN Tansel , ERGÜN Yusuf
Published: December 2022

Objective: The vaccine manufactured by Sinovac has been licensed according to the emergency use authorization program in Turkey. Inherently, this product has many shortcomings regarding safety issues. The aim was to explore the potential adverse reactions of the vaccine.
Materials and Methods: A retrospective cross-sectional study via a 24-item self-administered questionnaire was conducted among healthcare professionals.
Results: Of 133 persons, 51 subjects (38%) experienced adverse events after the first dose of the vaccine. The most common adverse events were fatigue, headache, diarrhea, and fever. Ninety five percent of the subjects (n=126) had the second dose of the vaccine and only 43 subjects (26%) described adverse events. These events were similar to those seen after the first dose. In one person, acute hypertension elevation was considered to be a serious adverse event. A female dominance regarding the frequency of adverse events was, solely, detected after the first dose administration.
Conclusion: Although there is a significant amount of adverse events in response to the vaccine, these cannot be identified as serious events. Therefore, this vaccine seems to be safe enough for those under the threat of the coronavirus disease 2019.