bluuebunny/crossref_metadata_2025 huggingface dataset:
In Vitro Synergistic Effect of Lefamulin with Doxycycline, Rifampin, and Quinupristin/Dalfopristin Against Enterococci
Authors: Min Yu-Hong , Kim Yong-ung , Park Min Chul
Published: December 2024

The widespread resistance of enterococci to many commonly used antimicrobial agents is a growing concern. Given that the current treatment options for enterococcal infections are limited, the discovery of new therapies, including combination therapies, is necessary. We evaluated double-drug combinations of lefamulin with doxycycline, rifampin, and quinupristin/dalfopristin for in vitro synergy against strains of Enterococcus faecium (E. faecium) and Enterococcus faecalis (E. faecalis) by using checkerboard and time-kill assays. In the checkerboard assay, the synergistic effect of lefamulin with doxycycline and rifampin was observed in 29 (85.3%) and 33 (97.1%) of the 34 different E. faecium strains tested, respectively. These combinations also showed synergistic effects against 17 (94.4%) of the 18 different vancomycin-resistant E. faecium strains. Among the 33 different E. faecalis strains, the combination of lefamulin with doxycycline, quinupristin/dalfopristin, and rifampin displayed synergistic effects in 31 (93.9%), 26 (78.8%), and 20 (60.6%) strains, respectively. No antagonism was observed in any of the combinations. The time-kill assay confirmed the synergistic effects of all these combinations. These synergistic combinations exhibited bacteriostatic activity. Although lefamulin is not currently used to treat enterococcal infections, we suggest that these combinations may serve as alternative drug regimens.
Heat Emissions from Mining Machinery: Implications for Microclimatic Conditions in Underground Workings
Authors: Zaitsev Artem , Parshakov Oleg , Semin Mikhail
Published: December 2024

The thermal regime of underground mines, shaped by air temperature, velocity, and relative humidity, is a crucial factor for production and the health and safety of miners. While many aspects of this thermal regime have been thoroughly studied in the literature, local heat sources from mechanized equipment, such as load–haul–dump machines, conveyors, and auxiliary fans, have received comparatively little attention despite their significant impact on the thermal environment in mining development areas and stopes. This paper presents findings from a comprehensive study of the microclimatic air parameters in several nickel–copper and potash mines. We focus specifically on variations in air temperature in areas where mining equipment is operational. The heat output from different types of equipment, including load–haul–dump units, cutter–loaders, drilling rigs, conveyors, and auxiliary fans, has been quantified. We established empirical relationships for heat emissions from these machines and conducted a comparative analysis of their heat outputs. The main advantage of these relationships is their simplicity and the minimal number of input parameters required, making them practical for use in the field.
Development and Application of a Robust Imine-Based Covalent Organic Framework for Stir Bar Sorptive Extraction of Estrogens in Environmental Water
Authors: Sun Jianing , Lian Xixi , Wang Lianzhi , Duan Zhengchao
Published: December 2024

A covalent organic framework (COF) based on imine was synthesized using 2,5-dihexoxyterephthalaldehyde (DHT) and 1,3,5-tris(4-aminophenyl) benzene (TAPB) as starting materials. The TAPB-DHT-COF exhibited satisfactory chemical stability, making it a promising adsorbing material for stir bar sorptive extraction (SBSE) of four estrogens, including estrone (E1), β-estradiol (E2), hexestrol (HES), and mestranol (MeEE2), in ambient water samples. The extracted analytes were subsequently analyzed using a high-performance liquid chromatography-diode array detector (HPLC-DAD). A series of parameters affecting the SBSE process, such as solution pH, ionic strength, extraction time, and desorption solvent, were investigated by the controlled variable method. Under optimal conditions, the limit of detection (LODs) for the four targeted estrogens ranged from 0.06 to 0.15 µg/L, with a linear range from 0.2 to 100 µg/L. The observed enrichment factor (EF) ranged from 39 to 49, while the theoretical EF was estimated to be 50-fold. This methodology can be applied to the identification of estrogens in three environmental water samples.
Effective Decolorization of Poly-γ-Glutamic Acid Fermentation Broth by Integrated Activated Carbon Adsorption and Isoelectric Point Precipitation of Glutamic Acid
Authors: Si Xiusheng , Li Jicheng , Zhao Tingbin , Cao Weifeng , Qiao Changsheng
Published: December 2024

Poly-γ-glutamic acid (γ-PGA) is widely used in the field of biomedicine, food, agriculture, and ecological remediation. For the biosynthesis of γ-PGA, the pigments and remaining glutamate are two big problems that impede γ-PGA production by fermentation, and a trade-off between the decolorization rate and γ-PGA recovery rate during the purification process was found. The optimized static activated carbon adsorption conditions for treating the 2-times diluted cell-free supernatant (i.e., feed solution) was as follows: 0.51% 200-mesh, 1000 iodine value, coal-based activated carbon, pH 6.0, 140 min, and 40 °C. Under the optimized conditions, the decolorization rate reached 94.42%, and the recovery rate of γ-PGA was 94.22%. During the adsorption process, the pigments were adsorbed on the activated carbon surface in a monolayer, and the process was a spontaneous, heat-absorbing, and entropy-increasing process. Then, the decolorization flow rate optimized for the dynamic decolorization experiment was 1 BV/h. However, the remaining glutamate was still a problem after the activated carbon adsorption. After isoelectric point (IEP) precipitation of glutamic acid, the glutamic acid can be recovered, and the residual pigment can be further removed. Finally, an integrated decolorization process of activated carbon adsorption and IEP precipitation of glutamic acid was developed. After the integrated process, the decolorization and glutamic acid precipitation rates were 95.80% and 49.02%, respectively. The recovered glutamic acid can be reused in the next fermentation process.
Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition
Authors: Studzińska-Sroka Elżbieta , Paczkowska-Walendowska Magdalena , Kledzik Justyna , Galanty Agnieszka , Gościniak Anna , Szulc Piotr , Korybalska Katarzyna , Cielecka-Piontek Judyta
Published: December 2024

Black elderberry (Sambucus nigra L.) flowers are rich in polyphenolic compounds, including chlorogenic acid and quercetin derivatives, which are known for their health benefits, particularly their antioxidant and antidiabetic properties. This study aimed to optimize the extraction conditions using the Box–Behnken model to maximize polyphenol yields from different elderberry flower cultivars and to evaluate their potential for antidiabetic action. The extracts were analyzed for their phytochemical content and assessed for enzyme inhibition, specifically targeting enzymes critical in carbohydrate digestion and glucose regulation. The anti-inflammatory activity was also assessed. Results indicated that the Black Beauty, Obelisk, and Haschberg cultivars demonstrated significant inhibition of α-glucosidase, with a high inhibitory potential against α-amylase enzymes for the Obelisk cultivar. Additionally, high chlorogenic acid content was strongly correlated with enzyme inhibition and antioxidant activity, suggesting its substantial role in glucose regulation. This study underscores the potential of elderberry flower extracts, particularly those rich in chlorogenic acid, as natural agents for managing blood glucose levels, warranting further exploration of their use in antidiabetic applications.
Fiber-Based Laser Doppler Vibrometer for Middle Ear Diagnostics
Authors: Waz Adam T. , Masalski Marcin , Morawski Krzysztof
Published: December 2024

Laser Doppler vibrometry (LDV) is an essential tool in assessing by evaluating ossicle vibrations. It is used in fundamental research to understand hearing physiology better and develop new surgical techniques and implants. It is also helpful for the intraoperative hearing assessment and evaluation of postoperative treatment results. Traditional volumetric LDVs require access in a straight line to the test object, which is challenging due to the structure of the middle ear and the way the auditory ossicles are accessible. Here, we demonstrate the usage of a fiber-based laser Doppler vibrometer (FLDV) for middle ear diagnostics. Compared to classical vibrometers, the main advantages of this device are the ability to analyze several arbitrarily selected points simultaneously and the flexibility achieved by employing fiber optics to perform analysis in hard-to-reach locations, which are particularly important during endoscopic ear surgery. The device also allows for a simple change in measuring probes depending on the application. In this work, we demonstrate the properties of the designed probe and show that using it together with the FLDV enables recording vibrations of the auditory ossicles of the human ear. The obtained signals enable hearing analysis.
Methane Adsorption Energy Variation Affected by Industrial Components in Deep and Thick Coal Reservoirs
Authors: Zhou Xiaogang , Wang Kai , Yan Baozhen , Qin Zhengyuan , He Shi , Quan Fangkai , Vandeginste Veerle
Published: December 2024

The relevant literature indicates that coal facies have a significant impact on the pore structure and adsorption properties of deep coal reservoirs. The content of submicroscopic components is used to calculate the parameters of coal facies. Based on traditional coal phase parameters and ash content, the coal phases of the coal samples in the study area were divided. Based on the adsorption potential theory, the differences in methane adsorption energy changes between different coal phases were compared. The results are as follows. The wet herbaceous swamp facies (type A) could be divided into two subtypes by using the ash yield: subtype A-1 (with an ash yield lower than 20% and a gel index (GI) lower than 5), and subtype A-2 (with an ash yield larger than 20% and a GI lower than 5). With the increase in micro-pore volume shown in A-1 samples, cumulative surface free energy increases linearly and the maximum rate of decline decreases linearly. Coal facies have an important effect on adsorption parameters: VL increases and PL decreases with higher structural preservation index (TPI). The effect of a low ash yield and different Ro,max on methane adsorption energy parameters is stronger.
Toluene Alkylation Reactions over Y-Type Zeolite Catalysts: An Experimental and Kinetic Study
Authors: Al-Sultani Samaa H. , Al-Shathr Ali , Al-Zaidi Bashir Y.
Published: December 2024

The present study demonstrated an improvement in both 1-heptene conversion and mono-heptyltoluene selectivity. It simultaneously depicted the isomerization reactions of 1-heptene and toluene alkylation over Y zeolite catalysts having a Si/Al of 3.5 and a surface area of 817 m2/g. The physical properties of the fresh zeolite catalyst were characterized using XRD, FTIR, XRF, TPD, and N2 adsorption–desorption spectroscopy. The experimental part was carried out in a 100 mL glass flask connected to a reflux condenser at different reaction temperatures ranging from 70 to 90 °C, toluene:1-heptene ratios of 3–8, and catalyst weights of 0.25–0.4 g. The highest conversion of ~96% was obtained at the highest toluene:1-heptene ratio (i.e., 8:1), 0.25 g of zeolite Y, at 180 min of reaction time and under a reaction temperature of 90 °C. However, the selectivity of 2-heptyltoluene reached its highest value of ~25% under these conditions. Likewise, the kinetic modeling developed in this study helped describe the proposed reaction mechanism by linking the experimental results with the predicted results. The kinetic parameters were determined by nonlinear regression analysis using the MATLAB® package genetic algorithm. The ordinary differential equations were integrated with respect to time using the fourth-order Runge–Kutta method, and the resulting mole fractions were fitted against the experimental data. The mean relative error (MRE) values were calculated from the experimental and predicted results, which showed a reasonable agreement with the average MRE being ~11.7%. The calculated activation energies showed that the reaction rate follows the following order: coking (55.9–362.7 kJ/mol) > alkylation (73.1–332.1 kJ/mol) > isomerization (69.3–120.2 kJ/mol), indicating that isomerization reactions are the fastest compared to other reactions. A residual activity deactivation model was developed to measure the deactivation kinetic parameters, and the deactivation energy value obtained was about 48.2 kJ/mol.
Evolution of Sow Productivity and Evaluation Parameters: Spanish Farms as a Benchmark
Authors: Sanz-Fernández Santos , Rodríguez-Hernández Pablo , Díaz-Gaona Cipriano , Tusell Llibertat , Quintanilla Raquel , Rodríguez-Estévez Vicente
Published: December 2024

This study examines the global evolution of sow productivity, with a particular focus on Spain. The analysis is based on key performance metrics such as piglets weaned per sow per year (PWSY), prolificacy, and pre-weaning mortality, utilizing data from literature reviews, the InterPIG, and BDporc® databases. Globally, significant advancements in genetic selection and management practices have led to productivity increases across major pig-producing countries, with notable improvements in prolificacy. However, higher prolificacy has been accompanied by rising piglet mortality rates during lactation, posing sustainability challenges. In Spain, the average productivity of commercial sows increased from 23.78 PWSY in 2009 to 29.45 PWSY in 2023, while Iberian sows reached an average of 17.44 PWSY. Despite these gains, Spain’s figures remain slightly below the European Union average. The study highlights the need for new benchmarks, such as non-productive days, piglet survival, and sow longevity, to more accurately assess farm efficiency. These indicators, combined with considerations for animal welfare and environmental sustainability, are crucial for addressing current challenges such as piglet mortality, sow culling, and the carbon footprint. The findings emphasize the importance of adopting comprehensive management strategies that balance productivity with growing social and environmental demands on the swine industry.
Social policy in civil aviation in Kyrgyzstan: challenges and development prospects
Authors:   Kyrgyz Aviation Institute named after I. Abdraimov Kyrgyz Republic, Bishkek, Sadovskaya O. A. , Ismailova J. K. ,   Kyrgyz Aviation Institute named after I. Abdraimov Kyrgyz Republic, Bishkek, Salmorbekova R. B. ,   Kyrgyz Aviation Institute named after I. Abdraimov Kyrgyz Republic, Bishkek
Published: December 2024

Civil aviation plays a key role in the economic development of Kyrgyzstan, providing
not only domestic but also international aviation connections. However, despite
the importance of this industry, the social policy in the country’s civil aviation faces many
challenges. This article examines the main problems that exist within the framework of
the social policy of civil aviation in Kyrgyzstan, as well as the prospects for its development
in the conditions of the modern market.
The content of social work with youth as an integral element of the state youth policy
Authors:   depar tment of social work and law, FSBEI HE «St. Petersburg State Universit y of Industrial Technologies and Design», St. Petersburg, Titkova M. V.
Published: December 2024

The article outlines the main priorities of the state youth policy of Russia.
Social work is considered as one of the key mechanisms for the implementation
of the goals and objectives of youth policy. The content of social work with young
people is revealed, its main tasks are highlighted. The article highlights the main
technologies of social work with young people.
Socio-cultural rehabilitation of children with disabilities by means of decorative and applied art
Authors:   Municipal Institution «Social Rehabilitation Center for Children and Adolescents with Disabilities» of Magnitogorsk,, Tatarnikova V. N. , Bezenkova T. A. ,   Department of Social Work and Psychological and Pedagogical Education of the Federal State Budgetary Educational Institution of Higher Education «Magnitogorsk State Technical University named after G. I. Nosov»
Published: December 2024

The article is devoted to the analysis of the problems of socio-cultural
rehabilitation of children with disabilities. The purpose of the article is to identify
the main trends in the use of decorative and applied arts in the rehabilitation
process and describe the content of work with this category of children. It was
revealed that for effective work with children with disabilities, it is important to
conduct classes with modeling elements, praise the child and develop skills in
various conditions and scenarios. Artistic activity can help children with disabilities
develop many important life skills, creativity and imagination, self-expression,
confidence and independence, and contribute to becoming full-fledged subjects
of public relations.
Gender dimorphism of the relationships between the cranial and facial skull sections in mature human individuals
Authors: Sosonna L.O.
Published: December 2024

Background. To date, the range of individual anatomical variability of the cranial profile type in mature adults, depending on gender and skull structure type has not yet been adequately established.

Aim. To study gender-specific ratios of the cranial and facial parts of the skull in mature adults.

Materials and Methods. The materials of our study consisted of 115 skulls of mature adults of both sexes, including 35 dry bone specimens of whole or fragmented skulls. For each parameter, the following metrics were calculated: The following parameters were used in the statistical analysis: (arithmetic mean), σ (standard deviation), and m (standard error of the mean).

Results. It was found that in men the skull length is =181.36 with σ=3.31 and m=0.46, while in women it does not exceed =176.57 with σ=3.28 and m=0.47; the skull width in men reaches =141.17 with σ=2.62 and m=0.34, and in women, it does not exceed =134.94 with σ=2.50 and m=0.33; the height parameter of the skull in men also reaches maximum values at the level of =141.38 with σ=3.75 and m=0.52, while in women, it is somewhat lower at =137.24 with σ=3.15 and m=0.55. In mature men, the upper facial width is =94.17 with σ=3.87 and m=0.50, while in women, this parameter averages =90.71 with σ=4.05 and m=0.54; the middle width in men reaches =128.93 with σ=1.53 and m=0.20, while in women, it does not exceed =122.49 with σ=1.44 and m=0.19; the maximum indicators of angular width are established in men, averaging =99.64 with σ=4.15 and m=0.54, while in women, they do not exceed =92.27 with σ=3.78 and m=0.51.

Conclusions. The study identified significant gender-specific differences in the cranial and facial dimensions of middle-aged individuals. Men demonstrated larger average values for skull length, width, and height, as well as upper face width, bizygomatic width, and angular width, compared to women. These findings highlight distinct morphological characteristics between genders.

Keywords: computed tomography, cranial index, face width, face length, face height.
“AFMERS” - Advance Fire Monitoring and Emergency Response System
Authors: Mendis Ridma , Pathinayake Jayavi , Sandeepa Kaveesha , Nalanda Chethana , Pandithage Dinithi , Gamage Narmada
Published: December 2024

The Advanced Fire Monitoring and Emergency Response System (AFMERS) presents an IoT-driven solution designed to reduce fire emergency response times and enhance firefighter safety. This integrated system includes automated fire detection, robotic firefighting, firefighter health monitoring, and a centralized command center. The system employs sensors to detect fires, assess type and severity, and immediately relay alerts to a firefighting robot and command center dashboard. The robot, equipped with adaptive extinguishing capabilities, is controlled by the operators in the command center to contain early-stage fires, while a wearable device monitors firefighter vitals and facilitates communication. A web-based and mobile dashboard consolidates live health, fire, and video data for real-time decision-making. Operators, using the AFMERS app, can activate the Help Me function to directly alert the Fire Department if the robot is unable to control the fire. Initial testing shows this research improves response efficiency and personnel safety, highlighting its potential to advance fire emergency response technology.
Track Scout – Smart Rail Infrastructure
Authors: Nithya Amshik , Bhoomika G B Bhoomika G B , Mahima S K Mahima S K
Published: December 2024

Railway systems are a crucial mode of transportation, facilitating the safe and efficient movement of people and goods. However, they often face hazards like animal crossings, fallen trees, and debris, which can cause accidents, delays, and even fatalities.The TRACK SCOUT system addresses these challenges by integrating advanced sensors and communication technologies to monitor and protect railway tracks. A combination of camera and infrared (IR) sensors continuously scans for obstacles, while a GPS module ensures accurate location tracking. LoRa (Long Range) communication enables real-time data transmission between the TRACK SCOUT and the train, providing immediate alerts and allowing timely responses to potential hazards.This review explores current technologies in automated railway track inspection and highlights future advancements, such as sensors for detecting track defects and derailment risks, aimed at enhancing railway safety and operational efficiency.
Modifikasi Pembelajaran Penjaskes di Sekolah Dasar Islam Terpadu Auladi Palembang
Authors: Martha Alfroki , Arisman Arisman
Published: December 2024

ABSTRAKPenelitian ini mendeskripsikan tentang Modifikasi  Pembelajaran Penjasorkes di SDIT Auladi Palembang. Modifikasi ini dibatasi pada Alat dan Peraturan. Jenis penelitian ini adalah deskriptif kuantitatif, yang mana penelitian ini melihat persentase penilaian dari analisis penelitian. Populasi dan sampel dalam penelitian ini adalah seluruh siswa SDIT Auladi Palembang yang berjumlah 256 orang. Teknik penarikan sampel yang digunakan adalah Purposive Sampling, yaitu adanya pertimbangan-pertimbangan tertentu, maka dari itu sampel yang dipilih berjumlah 20 Orang. Intrumen penelitian menggunakan angket penelitian dengan menggunakan Skala Likert. Hasil pengolahan data dari Modifikasi alat dengan persentase yang tinggi adalah pada Alternatif jawaban Sangat Setuju dengan persentase 49,95 %, Setuju 35,36%, Cukup Setuju 11,79 %, Kurang Setuju 2,90 %, Sangat Kurang Setuju 0%. Berdasarkan hasil dengan demikian, maka Modifikasi Pembelajaran Penjasorkes di SDIT Auladi Palembang berada pada kategori Cukup.
The Application of Artificial Intelligence for Anomaly Detection in Big Data Systems for Decision-Making
Authors: Octiva Cut Susan , Suryadi Dikky , Judijanto Loso , Laia Mitranikasih , Irwan Dedy
Published: December 2024

The development of big data technology has generated huge volumes of diverse data, creating challenges in detecting anomalies that could potentially affect decision-making. This research aims to examine the application of artificial intelligence (AI) in detecting anomalies in big data systems to support faster, more accurate and effective decision-making. The approach used includes the integration of machine learning algorithms, such as classification-based detection, clustering, and deep learning, in identifying abnormal patterns in large datasets. The research method involves real-time dataset-based simulations by measuring the performance of AI models using accuracy, precision, recall, and F1-score metrics. The results show that the application of AI can significantly improve the anomaly detection capability compared to conventional methods, with an average accuracy of 92%.
Advocacy
Authors: Marello Carla
Published: December 2024

Alcuni lettori ci chiedono se il termine advocacy abbia un corrispondente in italiano.
Morto-vivo: breve glossário crítico
Authors: Pera Luiz Renato Montone
Published: December 2024

Abjeto, body horror, close-up, ferida, gore, horror, necropolítica, terrir e zumbi são entradas deste glossário crítico imaginado a partir da figura do morto-vivo. Presente na cultura popular e midiática, este personagem, com suas ambiguidades, possibilita relacionar horror, artes visuais e cinema, contra o pano de fundo sociopolítico daquilo que a filósofa mexicana Sayak Valencia chama de “capitalismo gore”. Busca-se, aqui, pensar a relação entre a virtualidade da imagem – no presente neoliberal, caracterizada por superfícies lisas e luminosas próprias ao regime obsceno da circulação e da visibilidade totais – e a fisicalidade irredutível do corpo – traduzida, no gênero do horror e nos mortos vivos, por representações escatológicas da carne putrefata, da violência e da morte, sintomas sintetizados, em parte, pela noção de necropolítica. O texto se vale de uma forma fragmentária, ensaística e por associações por vezes díspares, de modo a incorporar a própria lógica dos objetos analisados.
BIOPROSPECT OF BACTERIAL FIBRINOLYTIC PROTEASE FROM BEKASAM OF LONGTAIL TUNA AS ANTITHROMBOTIC AGENT: LITERATURE REVIEW AND BIBLIOGRAPHY STUDY
Authors: Trianes Juwy , Ethica Stalis N. , Afriansyah M. Ardi , Darmawati Sri , Rahmani Nanik , Zilda Dewi S.
Published: December 2024

Introduction:Cardiovascular disease (CVD) is the leading cause of death worldwide, with thrombosis being a significant risk factor. Fibrinolytic proteases have potential as antithrombotic agents and could be developed into CVD drugs. Indonesia's traditional fermented products, such as fish Bekasam, are rich in microorganisms, including fibrinolytic protease-producing bacteria, yet their potential for CVD treatment is underexplored. Fish paste in Indonesia serves as a protein source and a reservoir of bacterial diversity, which could aid in discovering new antithrombotic agents. Objective: This literature review examines research trends over the past decade on fibrinolytic protease-producing bacteria in traditional fermented products, with a focus on Bekasam made from Longtail Tuna. This fermented food is an alternative source for obtaining bacteria with antithrombotic properties. Methods: Data for this review were sourced from Google Scholar, PubMed, and the dimension.ai database, using the keyword "bacterial fibrinolytic protease" from 2015 to 2024. Visualization of global research trends was performed using VOS viewer software. Results: The review found a scarcity of studies on fibrinolytic proteases from Bekasam bacteria. Lactic acid bacteria involved in Bekasam fermentation possess proteolytic enzymes that degrade fish protein into peptides and amino acids, potentially offering antithrombotic properties. This suggests natural protease sources from traditional fermented foods have significant biomedical potential. Research on fibrinolytic protease-producing bacteria from Bekasam in Indonesia is limited and requires further development. Exploring these local fermented products could yield innovative sources for thrombosis treatment
Primer reporte de abscesos hepáticos por Streptococcus intermedius de origen periodontal en Venezuela
Authors: Castillo Ayala Daniel , De Andrade Yuraima P. , Traviezo Luis E.
Published: December 2024

Streptococcus intermedius pertenece al subgrupo Streptococcus anginosus, siendo una bacteria betahemolítica, catalasa negativa, no móvil y Gram positiva, que en comparación con los otros integrantes de este grupo (Streptococcus anginosus y Streptococcus constellatus) tiende a potenciar mayormente las infecciones. S. intermedius se relacionó con abscesos hepáticos posteriores a infecciones dentarias, intestinales, tumores intestinales o colorrectales. El presente caso trató un paciente masculino de 44 años que acudió al hospital referido por presentar fiebre, hepatomegalia y dolor abdominal de un mes de evolución. Se realizó ultrasonido abdominal y tomografía axial computarizada de abdomen, apreciándose abscesos hepáticos producidos por S. intermedius (hemocultivo). El tratamiento de elección fue la combinación de drenaje, cirugía y terapia con antibióticos.
Prevalencia de caries dental en pacientes atendidos en la Universidad Laica Eloy Alfaro de Manabí
Authors: Cerón Diego A. , Guillén Ruth V.
Published: December 2024

El objetivo de esta investigación fue determinar la prevalencia de caries dental en pacientes que asisten a la Clínica Odontológica III de la Carrera de Odontología de la Universidad Laica Eloy Alfaro de Manabí (ULEAM) durante el período 2023-2. La caries dental representa un desafío significativo para la salud pública en Ecuador, con una alta incidencia que afecta la calidad de vida de la población. El objetivo principal fue evaluar la prevalencia de caries mediante el índice CPOD (dientes cariados, perdidos y obturados), un estándar en la epidemiología dental. Además, se analizó la distribución de este índice según variables como edad, género y nacionalidad, para identificar grupos de riesgo y factores asociados. La metodología propuesta fue un estudio retrospectivo con un diseño no experimental, retrospectivo y transversal, en el que se analizaron datos de 286 personas. Se establecieron criterios claros de inclusión y exclusión para asegurar la validez de los resultados.
III Conferencia Internacional de Ciencias de la Salud y su contribución a la innovación científica y desarrollo académico en Ciencias Médicas
Authors: García Mario A.
Published: December 2024

Se presenta el segundo número de la Revista Gregoriana de Ciencias de la Salud, un espacio dedicado a la difusión del conocimiento e investigación en Ciencias de la Salud. Este número tiene un significado especial, pues coincide con la reciente celebración de la III Conferencia Internacional de Ciencias de la Salud “Ciencia, educación médica y salud para la transformación social y el desarrollo sostenible”, organizada por la carrera de Medicina de la Universidad San Gregorio de Portoviejo. Este evento ha dejado una huella imborrable en nuestra comunidad académica y profesional.
Estado nutricional y calidad de vida del adulto mayor: revisión sistemática
Authors: Angulo Ashley A. , Rodríguez Daliannis , García Mario A.
Published: December 2024

Este estudio analizó el estado nutricional y su impacto en la calidad de vida de los adultos mayores en distintos contextos socioeconómicos. El objetivo fue identificar los factores asociados a la malnutrición en esta población y su relación con la aparición de comorbilidades. Se realizó una revisión sistemática de la literatura, seleccionando 30 artículos publicados en los últimos cinco años. Los resultados mostraron una alta prevalencia de malnutrición, especialmente en áreas rurales, y su asociación con enfermedades crónicas como la osteoartritis y la diabetes. Además, se observaron mejoras en la calidad de vida cuando se implementaron intervenciones nutricionales y programas de actividad física. Las conclusiones destacan la necesidad de fortalecer las políticas de salud pública enfocadas en la prevención de la malnutrición y el desarrollo de intervenciones sostenibles para los adultos mayores en situación de vulnerabilidad.
Conocimiento y aplicación de los principios bioéticos en el personal de salud del área de emergencia del Hospital General Portoviejo
Authors: Macías Mauro H. , Moreira María V. , Marín Alfredo L.
Published: December 2024

El presente estudio determinó el nivel de conocimiento y aplicación de los principios bioéticos en el personal de salud del área de emergencia del Hospital General Portoviejo. Se utilizó un diseño cuantitativo, observacional, descriptivo, transversal y correlacional, con una muestra de 67 profesionales seleccionados mediante muestreo probabilístico simple. Para la recolección de datos se utilizó un cuestionario sobre el nivel de conocimiento de los principios bioéticos y una lista de chequeo para evaluar su aplicación en la práctica clínica. Los datos fueron procesados a través de la prueba de Shapiro-Wilk para evaluar su normalidad y se realizaron análisis de varianza. Además, se calculó el odds ratio para determinar la asociación entre el nivel de conocimiento y aplicación de los principios bioéticos. Los resultados mostraron una distribución equitativa por sexo, un predominio de profesionales de 35 a 44 años y una mayoría residente en Portoviejo. El 30 % del personal mostró un conocimiento limitado de los principios bioéticos, y un 20,90 % no los aplicaba de manera consistente, revelando una brecha entre el conocimiento teórico y su aplicación práctica. La edad tuvo un efecto significativo (p ≤ 0,05) en el conocimiento y la aplicación de los principios éticos, mientras que el sexo no mostró una influencia relevante. Estos resultados evidencian la necesidad de mejorar la formación en bioética entre el personal de salud del área de emergencia, y sugiere la implementación de intervenciones dirigidas a cerrar la brecha entre el conocimiento y la práctica de estos principios.
Reassessing the Political Community: Politics and the Public Domain in Fifteenth-Century Scotland
Authors: Hawes Claire
Published: December 2024

It is over fifty years since the birth of the ‘new orthodoxy’ in the political history of fifteenth-century Scotland.1 Pioneered by Jenny Wormald and Alexander Grant, this approach cast aside the prevailing assumption, that late medieval Scotland was a wild and lawless place where overmighty magnates held sway over a weak crown, and replaced it with a model of political relations which had co-operation at its heart.2 Wormald argued that Scotland was so decentralised and ‘relatively underdeveloped’ in terms of legal institutions that the maintenance of order in the localities relied heavily upon the nobility, who were responsible for the administration of justice within their own jurisdictions.
Nefrología (XXVII Congreso)
Authors: Médica Colombiana Acta
Published: December 2024

MONITORIZACIâN, EVOLUCIâN Y PRONOSTICO EN PACIENTES CON ENFERMEDAD RENAL EN HEMODIALISIS CON INFECCION SEVERA POR SARS-COV 2
MONITOREO DIARIO DE LA EXCRECIâN URINARIA DE SODIO EN ENTORNOS DE CUIDADOS INTENSIVOS: UN MÿTODO SIMPLE PARA LA DETECCIâN TEMPRANA DE LA LESIâN RENAL AGUDA
VALORACIâN NUTRICIONAL EN PACIENTES RENALES EN HEMODIÁLISIS
HEMOGLOBINURIA PAROXISTICA NOCTURNA A PROPâSITO DE UN CASO
KOCURIA VARIANS, BACTERIEMIA EN UN PACIENTE EN HEMODIÁLISIS: REPORTE DE UN CASO
NEFROPATÍA INDUCIDA POR CONTRASTE EN PACIENTES CON SÍNDROME CORONARIO AGUDO Y ALTERACIâN DE LA FUNCIâN RENAL QUE SON LLEVADOS A ARTERIOGRAFÍA CORONARIA ENTRE 2019 Y 2020
CRISIS RENAL EN PACIENTE CON ESCLEROSIS SISTÿMICA: ¿PODRÍA PONERSE PEOR?
CARACTERIZACIâN DE LOS PACIENTES HOSPITALIZADOS CON COVID 19 Y LESIâN RENAL AGUDA EN DOS HOSPITALES UNIVERSITARIOS DE BOGOTÁ D.C
Neumología (XXVII Congreso)
Authors: Médica Colombiana Acta
Published: December 2024

NEUMOTâRAX COMO COMPLICACIâN DE CAVITACIONES POR TUBERCULOSIS PULMONAR
ASOCIACIONES DEL TEST DE MARCHA Y CATETERISMO PULMONAR EN PACIENTES CON HIPERTENSIâN PULMONAR CANDIDATOS A REHABILITACIâN EN COLOMBIA
SÍNDROME DE BAJO O ALTO PESO EN PACIENTES CON HIPERTENSIâN PULMONAR EN COLOMBIA
RESTRICCIONES DE CLASE FUNCIONAL PARA PREDICCIâN DE GRAVEDAD EN HIPERTENSIâN PULMONAR Y LAS IMPLICACIONES PARA INDICAR TRATAMIENTO
SOBREVIDA A LARGO PLAZO EN PACIENTES CON APNEA OBSTRUCTIVA DEL SUEçO EN UN HOSPITAL DE TERCER NIVEL EN COLOMBIA
MICROLITIASIS ALVEOLAR UNA PATOLOGÍA PULMONAR INFRECUENTE. A PROPâSITO DE UN CASO
ADMINISTRACIâN DE IBUPROFENATO POR VÍA INHALATORIA EN LA FASE AGUDA DE COVID-19: SEGURIDAD Y TOLERANCIA
TUBERCULOSIS PLEURAL EN PACIENTE JOVEN INMUNOCOMPETENTE
POLIPOSIS NASAL EN PACIENTE CON ASMA, RINOSINUSITIS Y ALERGIA A LOS AINES: LA OLVIDADA TRIADA DE SAMTER. REPORTE DE CASO
EMBOLIA PULMONAR EN CONTEXTO DE SARS COV 2 CON DIMERO D NEGATIVO
Oncología (XXVII Congreso)
Authors: Médica Colombiana Acta
Published: December 2024

CARCINOMATOSIS PERITONEAL SECUNDARIA A ADENOCARCINOMA PROSTÁTICO, REPORTE DE CASO
LINFOMA DE BAJO GRADO COMO ORIGEN DE LINFOMA DE ALTO GRADO: PRINCIPIO DE TRANSFORMACIâN
METÁSTASIS COROIDEA UNILATERAL DE UN ADENOCARCINOMA GÁSTRICO VARIEDAD INTESTINAL
METÁSTASIS INFRECUENTE EN CÁNCER GÁSTRICO
LINFOEPITELIOMA LIKE GÁSTRICO REPORTE DE CASO
Salud pública (XXVII Congreso)
Authors: Médica Colombiana Acta
Published: December 2024

COSTOS DIRECTOS DE MEDICAMENTOS DE LA DIABETES MELLITUS TIPO 2, EN POBLACIâN DE LA COSTA ATLÁNTICA COLOMBIANA 2021
COSTOS DE HOSPITALIZACION EN PACIENTES CON DIABETES MELLITUS TIPO 2 SEGUIDOS EN PROGRAMA DE RIESGO
Psiquiatría (XXVII Congreso)
Authors: Médica Colombiana Acta
Published: December 2024

PERFIL SOCIODEMOGRÁFICO Y CLÍNICO DE LOS PACIENTES EN QUIENES SE DETECTA CONSUMO DE COCAÍNA EN LA ATENCIâN EN UN SERVICIO DE URGENCIAS DE UN HOSPITAL DE ALTA COMPLEJIDAD DE LA CIUDAD DE MEDELLÍN
WHAT HAPPENS TO UNCERTAINTY IN NEURAL NETWORKS UPON PRUNING?
Authors: Bagdiya Aarush , Sharma Ashish Kumar
Published: December 2024

Training large neural networks can be costly. Sometimes large neural networks learn unneces- sary features which leads to poor performance on
test data set. To tackle these issues, it is best to remove the unwanted edges or the entire neu- ron that is affecting the accuracy of the model. Pruning
the network is one such solution that im- proves the accuracy, speed and uncertainty in the model.
HYPERCALCEMIA CAUSING DIAGNOSTIC DILEMMA IN AN ELDERLY FEMALE : A CASE REPORT
Authors: Maitra Somnath
Published: December 2024

Hypercalcemia is incidentally detected on routine laboratory evaluation in a number of patients .Very often it gives a diagnostic clue to the
underlying disorder .A combination of hypercalcemia with a raised immunoreactive parathormone(IPTH) gives a diagnostic clue to the underlying
disorder and helps to differentiate benign from malignant disorder. Here , an interesting case of hypercalcemia with raised IPTH and anaemia is
presented in an elderly female, which was diagnostic of primary hyperparathyroidism with an incidentally detected single parathyroid adenoma . It
was differentiated from tertiary hyperparathyroidism by absence of chronic kidney disease and lack of secondary hyperparathyroidism which leads
to tertiary hyperparathyroidism.
TO COMPARE FUNCTIONAL OUTCOMES OF PROXIMAL HUMERUS FRACTURE TREATED BY PHILOS AND TENSION BAND TECHNIQUE
Authors: Menwal Gaurav , Sharma Rohit Kumar , Tomar Shashank , Khan Azad , Ahmed Parwej , Swarn Kamal
Published: December 2024

Background : PHILOS technique for the management of proximal humerus fracture provides exceptional stability during fracture however the
technique is invasive , On the other hand, tension band wiring is a less intrusive technique .Therefore we aimed to evaluate the comparative
outcomes of both the techniques. Material & Method : Thirty patients with proximal humerus fracture were enrolled in this study and randomized
into two groups i.e PHILOS (N=15) and Tension band (N=15).The patients were followed until 4week, 12 week, 6 month. Radiological union, Pain
on activity , quality of life (DASH score ) , Clinical outcome (Range of motion ) and functional outcome (Constant murley score and Oxford
shoulder score ) were assessed .Any complications were also reported during the follow up interval. Results : The demographic profile was
comparable in both the groups . However , the clinical and functional outcome was significantly better in patients in PHILOS group as compared to
tension band group .(p<0.05) . Amongst the early complications , deep infection was observed in one patient in PHILOS group and two cases in
Tension band group.Tension band group also had three cases of K wire loosening and 1 case of neurovascular complication.i.e Neuropraxia of
axillary nerve)Amongst late complications , one patient had secondary osteoarthritis and 1 patient had joint stiffness.In tension band group , two
cases each of secondary osteoarthritis and joint stiffness was observed . Conclusion – It can be concluded that , PHILOS system provides better and
stable fracture fixation for early mobilization when compared with tension band with K wiring as treatment option for proximal humerus fracture
A RETROSPECTIVE STUDY EVALUATING PROCALCITONIN AS AN EARLY BIOMARKER FOR SEVERITY OF PLASMODIUM FALCIPARUM MALARIA
Authors: Choudhary Animesh , Jaiswal Deepak , Motiramani Nikhil
Published: December 2024

Background: Malaria is commonly encountered parasitic infection with varying degrees of severity. Though microscopy is the gold standard for
diagnosis, there has been search for surrogate biomarkers for predicting severity. Therefore, the present study was conducted to evaluate the
efficacy of procalcitonin as a biomarker. Method: The records of 100 patients diagnosed with Plasmodium falciparum malaria were included.
Demographic details, past and personal history, details of hematological examination and peripheral smear findings were noted. The data was
recorded and analysed. Results: In the present study, 65% (65 cases) of the cases had severe malaria. There was a male preponderance in the study
population. The serum procalcitonin was also significantly raised in cases with severe malaria as compared to the cases with uncomplicated malaria
(P value: less than 0.001) and showed significantly strong correlation with ESR, CRP and parasite count (P value: less than 0.001). Conclusion: It
can be effectively concluded that serum procalcitonin levels are significantly raised in severe malaria as compared to the uncomplicated malaria,
making it an effective biomarker for the severity of the disease.
EVALUATION AND CORRELATION OF HAEMATOLOGICAL PARAMETERS AND BIOCHEMICAL INDICES (UREA, CREATININE)IN PATIENTS WITH CHRONIC KIDNEY DISEASE UNDERGOING HAEMODIALYSIS IN A TERTIARY CARE HOSPITAL IN MID-WESTERN INDIA-A TWO YEAR PROSPECTIVE STUDY
Authors: Dutta Debanjan , Batabyal Subhayan , Jain Chetna
Published: December 2024

Background:Chronic kidney disease is a worldwide public health problem besides being one of the emerging life-threatening diseases in India as
well. It is invariably associated with various biochemical and hematological abnormalities leading to morbidity and mortality.The aim of this study
is to evaluate and correlate the haematological and biochemical parameters(urea,creatinine) in CKD patients undergoing haemodialysis.
Methods: This study is hospital based analytical observational cross sectional study conducted over a period of two years on whole blood samples
of 236 CKD patients undergoing haemodialysis at dialysis centre of SRG Hospital and Medical College,Jhalawar. Samples were analyzed using a
Sysmex XN-1000 automated hematology analyzer and Beckman Coulter DxC 700 AU automated biochemical analyzer. Data were analyzed
using IBM SPSS v22 software for Windows. Results:In this study, the maximum number of patients are in the age group 66-80 years 129 (54.7%).
Most of the participants are male 178 (75.4%) while the rest are female 58 (24.6%). Atotal of 159(67.37%) participants had history of both diabetes
and hypertension. It is found out that Fatigue is the most common((85.6%) complaint of the patients . A total number of 232[98.3%] patients are
suffering from Stage 5 CKD. We see that most of the patients are suffering from Normocytic Normochromic Anaemia-180(76.3%). It is found out
that total WBC count shows a statistically significant(p value=0.023 i.e.<0.05) negative correlation with serum urea. It is found out that with
respect to serum creatinine levels RBC count has a statistically significant(p value=0.030 i.e.<0.05) negative correlation, MCHC also has a
statistically significant(p value=0.017 i.e.<0.05)negative correlation and so does MCH(p value=0.034 i.e.<0.05).
TO STUDY THE EFFECTIVENESS OF INTERNATIONAL CONSENSUS GROUP FOR HEMATOLOGICAL REVIEW (ICGHR) CRITERIA FOR MANUAL PERIPHERAL SMEAR REVIEW
Authors: Kumari Shweta , Diwan Rishi
Published: December 2024

Background: The automation of hematology has transformed blood analysis, especially with the integration of analyzers for accurate complete
blood count (CBC) assessments. Despite these advancements, manual examination through peripheral blood film (PBF) remains crucial for
detecting subtle morphological abnormalities in blood cells. Objective: To compare the performance of ICGHR criteria with in-house laboratory
criteria for PBF review and assess their impact on the identification of blood abnormalities.Methods: A prospective cross-sectional comparative
study was conducted at the central laboratory of SRG Hospital, Jhalawar, Rajasthan, involving 800 adult whole blood samples sent for CBC testing.
Samples were analyzed using a Sysmex XN-1000 automated hematologyanalyzer and underwent manual smear review and 100-cell differential
counts. The analysis followed adapted ICGHR and in-our laboratory criteria, with systematic random sampling and strict quality control. Results:
Of the 800 samples, 379 (47.38%) were positive according to ICGHR review criteria, while 421 (52.63%) were negative. Among the positive
samples, 359 (94.72%) had positive smear findings, whereas 20 (5.28%) were smear-negative. According to laboratory criteria, 557 samples
(69.63%) were positive, with 411 (73.79%) confirming positive smear findings. The comparison revealed that all parameters from laboratory
criteria were significantly different from ICGHR criteria (P < 0.001). Conclusion: The study demonstrated that the laboratory criteria facilitated a
higher microscopic review rate (69.6%) compared to ICGHR criteria (47.25%), allowing for timely identification of abnormal specimens without
significantly increasing workload.
BARRIERS AND OPPORTUNITIES IN IMPLEMENTING ADULT VACCINATION: AN ASSESSMENT OF KNOWLEDGE, ATTITUDES, AND PRACTICES IN INDIA
Authors: Sillat Mohammed Shakeel , Rupali Priscilla , Kumar J. Vignesh , P G Maya
Published: December 2024

Background: Despite the effectiveness of childhood immunization initiatives, the adoption of adult vaccination remains limited in developing
nations such as India, resulting in a considerable burden of vaccine preventable diseases. Factors associated with the inadequate coverage have not
been thoroughly studies within our demographic. Materials and Methods: A cross-sectional survey was conducted among Indian adults to
evaluate their awareness of recommended vaccines, attitudes towards vaccination, and current vaccination practices. Statistical analysis was
performed to identify correlations between demographic factors and vaccination status. Results: The survey revealed a significant deficiency in
vaccine knowledge, with only 4.9% of respondents aware of all recommended vaccines. While 70.9% were familiar with at least one vaccine, only
54.3% knew of two or more. Awareness was highest for the tetanus, diphtheria, and pertussis vaccine (63.5%), but considerably lower for hepatitis
B, pneumococcal, and influenza vaccines. Awareness of HPV, herpes zoster, meningococcal meningitis, and H. influenzae type b vaccines was
around 10%. The primary source of vaccination information was healthcare providers (70.2%), yet only 35.6% had received vaccination advice
from their physicians. Barriers to vaccination included lack of awareness (67.8%), cost concerns, and safety fears. Only 43.8% had received at least
one recommended vaccine, with tetanus being the most common, while uptake for vaccines like herpes zoster, MMR, and HPV was very low.
However, most unvaccinated individuals expressed a willingness to get vaccinated if recommended by a physician. Conclusion: There is a critical
need to enhance adult vaccination awareness and coverage in India. While healthcare providers play a crucial role in influencing vaccination
decisions, their potential is underutilized. Comprehensive strategies, including public awareness campaigns, cost reduction, and healthcare
provider education, are essential to improve adult vaccination rates. Addressing these gaps can mitigate the burden of communicable diseases,
contributing to better public health outcomes.