bluuebunny/crossref_metadata_2025 huggingface dataset:
MiR 378a/FSCN1 regulatory axis inhibits tumor stemness and increases the cytotoxicity of chemotherapeutic drugs in colorectal cancer cells
Authors: Zhang Taizhe , Du Jie , Li Sandang , Zheng Chuanming , Wang Zhenjie , Xie Fuchen
Published: February 2023

Purpose: To evaluate the effect of miR-378a/FSCN1 axis on tumor stemness and aerobic glycolysis in colorectal cancer cells (CRC).

Methods: Abnormal expressions of miR-378a and FSCN1 in CRC tissues were analyzed through TCGA database. Cell viability and apoptosis were determined using 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT) assay and flow cytometry, respectively, while expression of miR-378a was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). Furthermore, Western blotting assay was used to assess protein expressions. The miR-378a target was evaluated using ENCORI and confirmed by luciferase assay. Aerobic glycolysis was evaluated by determining glucose uptake, lactate production and lactate dehydrogenase (LDH) activity.

Results: Downregulation of miR-378a and upregulation of FSCN1 were observed in both CRC tissues and cell lines (p < 0.05). Overexpression of miR-378a and repression of FSCN1 reduced cell viability and tumor sphere formation, and induced cell apoptosis. Protein expression of SOX2, KLF4, Bmi1 and Oct-4 were downregulated by either the overexpression of miR-378a or repression of FSCN1 (p < 0.01). Glucose uptake, lactate production and LDH activity were inhibited by either overexpression of miR-378a or repression of FSCN1, while cytotoxicity of Dox and 5-Fu was increased by upregulation of miR-378a or downregulation of FSCN1 (p < 0.05). The predictive results of ENCORI demonstrated that FSCN1 was the direct target of miR-378a, and this was confirmed by luciferase assay results (p < 0.005). All the effects of miR-378a in CRC were reversed by overexpression of FSCN1 (p < 0.05).

Conclusion: This study has shown that miR-378a suppresses tumor stemness and increases the cytotoxicity of chemotherapeutic drugs by directly targeting FSCN1, resulting in the prevention of CRC tumorigenesis. Thus, these findings suggest a new approach to the chemotherapeutic management of CRC.
Knockdown of PLAGL2 in hibits oral squamous cell carcinoma cell growth and cisplatin resistance via ZEB1/PD L1 pathway
Authors: Zhang Changqing , Ye Fei
Published: February 2023

Purpose: To investigate the effects of pleomorphic adenoma gene like-2 (PLAGL2) on oral squamous cell carcinoma (OSCC).

Methods: The effects of PLAGL2 on OSCC (CAL-27 and HSC-3) were conducted with loss- and gain-functional assays. Cell proliferation was determined by Cell Counting Kit-8 (CCK8) and colony formation assays. Cell metastasis was assessed by Transwell and wound healing assays. Cell apoptosis of cisplatin-resistant OSCC was evaluated by flow cytometry.

Results: PLAGL2 expression was significantly elevated in OSCC (p < 0.001), while silencing of PLAGL2 significantly reduced cell proliferation and metastasis of OSCC (p < 0.001). However, overexpression of PLAGL2 promoted OSCC progression through increase in cell proliferation, invasion, and migration. Knockdown of PLAGL2 promoted cell apoptosis of -resistant OSCC, but significantly downregulated protein expression of programmed cell death ligand 1(PD-L1) and zinc finger E-box-binding homeobox 1 (ZEB1) in OSCC (p < 0.01). Moreover, loss of ZEB1 attenuated the PLAGL2 overexpression-induced increase in ZEB1 and PD-L1. Loss of PLAGL2 also reduced in vivo tumor growth of OSCC via regulation of cluster of differentiation 4 protein (CD4) and CD8.

Conclusion: Knockdown of PLAGL2 exerts anti-tumor effects, improves cisplatin resistance, and enhances anti-tumor immunity in OSCC through suppression of ZEB1/PD-L1 pathway. Thus, PLAGL2 might be a potential therapeutic target for the treatment of OSCC.
Fast Symbolic Algorithms for Omega-Regular Games under Strong Transition Fairness
Authors: Banerjee Tamajit , Majumdar Rupak , Mallik Kaushik , Schmuck Anne-Kathrin , Soudjani Sadegh
Published: February 2023

We consider fixpoint algorithms for two-player games on graphs with
$\omega$-regular winning conditions, where the environment is constrained by a
strong transition fairness assumption. Strong transition fairness is a widely
occurring special case of strong fairness, which requires that any execution is
strongly fair with respect to a specified set of live edges: whenever the
source vertex of a live edge is visited infinitely often along a play, the edge
itself is traversed infinitely often along the play as well. We show that,
surprisingly, strong transition fairness retains the algorithmic
characteristics of the fixpoint algorithms for $\omega$-regular games -- the
new algorithms have the same alternation depth as the classical algorithms but
invoke a new type of predecessor operator. For Rabin games with $k$ pairs, the
complexity of the new algorithm is $O(n^{k+2}k!)$ symbolic steps, which is
independent of the number of live edges in the strong transition fairness
assumption. Further, we show that GR(1) specifications with strong transition
fairness assumptions can be solved with a 3-nested fixpoint algorithm, same as
the usual algorithm. In contrast, strong fairness necessarily requires
increasing the alternation depth depending on the number of fairness
assumptions. We get symbolic algorithms for (generalized) Rabin, parity and
GR(1) objectives under strong transition fairness assumptions as well as a
direct symbolic algorithm for qualitative winning in stochastic
$\omega$-regular games that runs in $O(n^{k+2}k!)$ symbolic steps, improving
the state of the art. Finally, we have implemented a BDD-based synthesis engine
based on our algorithm. We show on a set of synthetic and real benchmarks that
our algorithm is scalable, parallelizable, and outperforms previous algorithms
by orders of magnitude.
Relationship between Press Mentions and Brand Awareness
Authors: Babich Nikolay S. , Senchilo Bogdan S.
Published: February 2023

The article is devoted to the study of the process of brand awareness formation under the influence of mass media. Knowing the parameters of this process allows us to answer the question of how many times a person must meet a brand in the media environment in order to remember it, and what extent of brand mentioning in the media must be achieved in order to get a certain level of its popularity. Two aspects of awareness are singled out: recall (knowledge without prompting) and recognition (knowledge with prompting). An empirical study was carried out, which made it possible to isolate and measure, on a sufficient level of accuracy, the influence of the Russian central press on the brand awareness of more than 20 sociological companies in Russia over a period of 15 years. It showed that the presence of a brand in the press is significant, and it affects linearly both forms of awareness – recall and recognition. A strong linear relationship allows us to calculate the effective frequency of introductions and to build a predictive model for the formation of brand awareness under the influence of the media, as well as, using plausible assumptions, to estimate the effective frequency of contacts.
Videogames as a Digital Attempt to Touch the Mythological
Authors: Rezvushkina Sofya A.
Published: February 2023

The article deals with the analysis of video games and the use of VR technologies in the gaming sphere. The trend towards increasing gamification of modern man's being is examined and problematized. The main question raised by the author is what is the actual status of video games in the existence of modern man.

The aim of the research is to study the ontoanthropology of video games, and VR games in particular, and search for their correlates with archaic practices. This, in turn, led to the consideration of the ontoanthropology of the virtual and the ontoanthropology of the game as its variety.

The author comes to a conclusion that video games are a substitute for initiation which is most fully and safely performed by means of immersive equipment and taking rite-ritual activity into virtual reality. The results of the study can be used for an expert assessment of video games, identifying the prospects for their implementation in pedagogical, psychological or other consulting activities aimed at achieving a sense of inner transformation of the person in the direction of greater completeness and authenticity of existential experience. The findings can form the basis for philosophical conceptualization of modern mechanisms of digital identity formation and contribute to the growth of socio-humanitarian reflection on the problem of human self-identification and methods of achieving a sense of ontological fundamentality and wholeness of being in a virtual reality.
Izazovi provedbe digitalne transformacije funkcije upravljanja ljudskim potencijalima u mikropoduzećima te malim i srednjim poduzećima Republike Hrvatske
Authors: Perkov Davor
Published: February 2023

Razvoj digitalizacije interno utječe na organizacije na mnogim razinama jer zahtijeva upravljanje promjenama, odnosno prilagodbu, razvoj kompetencija i uvođenje novih načina rada. Digitalna transformacija kontinuirano mijenja način na koji organizacije regrutiraju, zapošljavaju, motiviraju i zadržavaju ljude. Cilj je rada analizirati izazove provedbe digitalne transformacije funkcije upravljanja ljudskim potencijalima u malim i srednjim poduzećima Republike Hrvatske. Osnovna hipoteza rada je da digitalizacija funkcije upravljanja ljudskim potencijalima rezultira rastom tržišnog udjela poduzeća. Primarni izvori dobiveni su putem empirijskog istraživanja provedenog online anketiranjem 105 ispitanika koji su zaposleni u odjelima za upravljanje ljudskim potencijalima hrvatskih mikropoduzeća te malih i srednjih poduzeća. Iz rezultata proizlazi da se u sektoru malih i srednjih poduzeća Republike Hrvatske u značajnoj mjeri koriste novi, digitalizirani kanali za regrutiranje zaposlenika. Proizašlo je i da su najveće prednosti digitalne transformacije funkcije upravljanja ljudskim potencijalima niži operativni troškovi, jednostavniji i brži procesi, manja birokracija te omogućeni rad od kuće.
Rol de los canales de sodio voltaje dependientes en la fisiopatología de la neuralgia del trigémino.
Authors: De la Cruz-Rodríguez Ronald , Sernaque-Roca Katharine , Aguirre-Siancas Elías
Published: February 2023

La neuralgia del trigémino es un trastorno crónico grave que provoca dolor paroxístico y que disminuye dramáticamente la calidad de vida de quien la padece. Si bien se ha estudiado bastante la fisiopatología del mal, aún no están claros los procesos moleculares subyacentes; sobre todo, el rol que cumplen los canales de sodio voltaje dependientes en el desencadenamiento de las crisis dolorosas. La presente revisión busca compendiar y actualizar el importante rol que juegan los canales de sodio voltaje dependientes en la fisiopatología de la neuralgia del trigémino, haciendo énfasis en las alteraciones estructurales, funcionales y genéticas de dichos canales. Se concluye que la neuralgia del trigémino se relaciona con alteraciones, tanto congénitas como adquiridas, en la expresión de diversas isoformas de los canales de sodio voltaje dependientes.
Perspectiva histórica y actualidad de los síndromes antigangliósidos.
Authors: Mauri-Fábrega Lara
Published: February 2023

Los síndromes antigangliósidos constituyen un espectro clínico amplio. Su conocimiento ha evolucionado desde las descripciones clásicas puramente clínicas hacia un desarrollo amplio de la inmunopatología subyacente a estos procesos y sus posibilidades de tratamiento. En el presente trabajo se lleva a cabo una revisión bibliográfica, analizando dicha evolución desde la perspectiva histórica hasta nuestros días en cuatro niveles: clínico, topográfico, inmunológico y terapéutico. Se analizan de forma crítica nociones topográficas e inmunológicas ya conocidas, pero poco integradas aún en la práctica clínica habitual. Se debate la necesidad de establecer una nomenclatura unificada para estos síndromes estratificada en dos niveles: el clínico y el inmunológico. Finalmente, se revisan las líneas terapéuticas presentes y en desarrollo en la actualidad.
Psicosis orgánica, tipo trastorno esquizofreniforme, posterior a hemorragia subaracnoidea.
Authors: González-Arteaga Alex , Pérez-Ortiz Jenniffer , Garrido-Sornoza Gustavo
Published: February 2023

La psicosis orgánica hace referencia a un grupo de enfermedades clasificadas en la actualidad como “trastorno psicótico debido a otra afección médica”, a diferencia de la ausencia de causalidad orgánica específica que hay en los trastornos primarios. Se trata de cuadros secundarios a procesos de larga duración, que es necesario reevaluar con frecuencia debido a la asociación entre el deterioro relacionado con la edad, la comorbilidad y la propia evolución de la psicosis. Presentamos el caso de una paciente con hemorragia subaracnoidea secundaria a ruptura de malformación arteriovenosa, que padeció de cambio leve en el comportamiento y disminución en las funciones cognitivas con posterior evolución a cuadros disociativos, episodios de hipersomnia y desconexión del medio, mediante la valoración conjunta de especialidades se llego al diagnóstico de psicosis orgánica tipo trastorno esquizofreniforme.
Tetanus in an Injecting Buprenorphine Abuser
Authors: Teo Felicia SW , Hsu Li Yang , Lam Khim Nian Sin Fai , Johan A
Published: February 2023

Introduction: Injecting drug abusers are vulnerable to many infectious complications. We describe a case of tetanus in a Singaporean who regularly abused buprenorphine. Clinical Picture: A 49-year-old male was hospitalised for progressive generalised spasms associated with dysarthria and opisthotonus. Tetanus was diagnosed clinically.

Treatment: Supportive management was instituted in the intensive care unit (ICU). Toxicology samples tested positive for buprenorphine.

Outcome: He recovered rapidly and was transferred out of the ICU after 8 days. Retrospective questioning confirmed parenteral abuse of buprenorphine.

Conclusion: This case highlights an uncommon and potentially lethal complication of parenteral drug abuse.

Key words: Clostridia, Buprenorphine, Drug abuse
Narrativas de la práctica pedagógica de entrenadores de fútbol en Colombia (Narratives of the pedagogical practice of soccer coaches in Colombia)
Authors: Rengifo Cruz Ricardo
Published: February 2023

El siguiente trabajo tiene como objetivo principal analizar la práctica pedagógica de seis entrenadores de fútbol de Colombia a partir de las necesidades pedagógica en este campo de formación se observa que la exigencia que tiene la profesión de entrenador requiere una serie de elementos tanto pedagógicos, didácticos y específicos en el campo del entrenamiento. La apuesta metodológica que adopto el trabajo es mediante un enfoque cualitativo con un tipo de estudio descriptivo a partir de una entrevista a profundidad, observación y diario de campo como herramientas que se utilizaron para este estudio. En cuanto a los resultados encontrados en las distintas relaciones que se establecen como técnica, flexible, cordial, jerárquica entre los sujetos entrenador – deportista, se determina que respecto a los resultados evidenciados, la relación que predomina es la flexible en proporción a las demás, la cual afecta negativamente el desarrollo correcto de la práctica pedagógica, ya que los entrenadores no delimitan esta relación, por lo que se termina creando espacios donde los deportistas se colocan a un mismo nivel del entrenador, por ende, no acatan las tareas que se les delega de modo que no permite el correcto desarrollo de la práctica, es así como se concluye que no hay una relación consolidada donde ambos puedan generar espacios que aporten al aprendizaje y a un correcto desarrollo de la práctica pedagógica.
Palabras claves: aprendizaje, fútbol, entrenadores, pedagogia, formación
Abstract. The main objective of the following work is to analyze the pedagogical practice of six Colombian soccer coaches based on the pedagogical needs in this training field, it is observed that the requirement of the coaching profession requires a series of pedagogical, didactic and specific to the field of training. The methodological commitment that the work adopts is through a qualitative approach with a type of descriptive study based on an in-depth interview, observation and field diary as tools that were used for this study. Regarding the results found in the different relationships that are established as technical, flexible, cordial, hierarchical between the coach-athlete subjects, it is determined that with respect to the results evidenced, the relationship that predominates is the flexible one in proportion to the others. which negatively affects the correct development of the pedagogical practice, since the coaches do not delimit this relationship, so it ends up creating spaces where the athletes are placed at the same level as the coach, therefore, they do not comply with the tasks that are assigned to them. delegates in such a way that it does not allow the correct development of the practice, this is how it is concluded that there is no consolidated relationship where both can generate spaces that contribute to learning and a correct development of the pedagogical practice.
Keywords: pedagogic practice, football, coaches, pedagogy, training
Desenvolvimento de formulações para Kits de diagnóstico in vitro para a dosagem de Ácidos Graxos Não Esterificados (NEFA) e Ácidos Biliares Totais (TBA) por bioquímica líquida com aplicação para saúde humana e veterinária
Authors:   , Reis Bianca Cristina Carvalho
Published: February 2023

Os ácidos biliares totais (TBA) e os ácidos graxos não esterificados (NEFA) são metabólitos produtos do metabolismo do colesterol e triglicerídeos respectivamente. A alta concentração de TBA acomete o fígado e vesícula biliar, incitando doenças como colestases, hepatites, cirroses e esclerose do fígado. Já a alta concentração de NEFA possui correlação direta com o estado nutricional do organismo e é alterado em doenças como obesidade e diabetes tipo II. De modo geral, a quantificação desses analitos são de extrema importância para auxílio diagnóstico de diversas doenças hepatobiliares e metabólicas que acometem a saúde humana e animal. Devido a necessidade de diagnóstico precoce, rápido, fácil e prático, o objetivo desse trabalho buscou desenvolver duas formulações para kits de diagnóstico in vitro para quantificação de TBA e NEFA por bioquímica líquida. Além disso, do ponto de vista empresarial objetivou-se reduzir custos e nacionalizar tecnologia. A formulação desenvolvida para NEFA promove a quantificação do analito por meio de uma cascata de reações enzimáticas, o qual o seu produto pode ser dosado por colorimetria de forma específica frente aos principais interferentes endógenos. Enquanto a dosagem pela formulação de TBA ocorreu por leitura espectrofotométrica da formação de ThioNAD em ciclos de oxidação e redução enzimática. Para o desenvolvimento de ambas as formulações foram realizadas pesquisas bibliográficas e ensaios de otimização para melhoramento de performance para atingir os parâmetros determinados e exigidos no mercado de diagnóstico in vitro para cada analito. Sendo assim, houve mudanças na composição e concentrações para atingir melhor exatidão, robustez frente aos interferentes endógenos comuns, determinação de intervalo operacional e estabilidade. A formulação de TBA foi finalizada com sucesso enquanto a formulação de NEFA ainda necessita de modificações para melhorar o desempenho de estabilidade. Contudo, ambas demonstraram bom desempenho, de forma se tornar potencialmente competitiva, compatível ao mercado e útil no auxílio diagnóstico in vitro de relevância clínica animal e humana. Palavras-chave: Ácidos graxos não esterificados. NEFA. Ácidos biliares totais (TBA). Doenças metabólicas. Doenças hepatobiliares. Diagnóstico in vitro.
Penerokaan Nilai Agama Berasaskan Maqasid Syariah dalam Meningkatkan Kebahagiaan Keluarga
Authors: Abdul Aziz Abdul Rashid
Published: February 2023

Umum mengetahui setiap perkahwinan berpotensi untuk berdepan dengan cabaran dan masalah. Isu-isu kekeluargaan seperti kes penceraian, keganasan rumah tangga dan penderaan kanak-kanak dilihat merekodkan peningkatan yang luar biasa pada tahun 2020. Kesejahteraan merupakan elemen terpenting dalam kehidupan berkeluarga. Islam sendiri memberi perhatian serius terhadap aspek kebahagiaan ini. Justeru, penulisan ini bertujuan melihat cabaran krisis rumah tangga yang memberi penumpuan kepada aspek spiritual (kerohanian) berasaskan konsep Maqasid Syariah dalam meningkatkan kebahagiaan keluarga. Metod kajian ini adalah berdasarkan kajian kualitatif melalui reka bentuk kajian skop (scoping review). Sebanyak 40 artikel telah dijumpai dan dipilih dari pangkalan data universiti seperti Online Public Access Catalog (OPAC), Proquest Central dan EBSCO-Host, bermula dari tahun 2010 hingga Disember 2022. Perbincangan perspektif maqasid syariah dalam memelihara institusi keluarga berfokus kepada lima teras prinsipnya iaitu menjaga agama, menjaga nyawa, menjaga akal, menjaga keturunan serta menjaga harta. Kajian mendapati bahawa praktis dan pengamatan nilai agama berasaskan Maqasid Syariah membawa kepada peningkatan kebahagiaan keluarga. Konklusinya, kajian ini amatlah penting sebagai panduan dan alat bantu bagi kaunselor mahupun badan-badan yang sentiasa berurusan dengan hal ehwal rumah tangga seperti Jabatan Agama Islam Negeri dalam membantu memberikan jalan penyelesaian kepada setiap individu yang memerlukan.
Kebijakan Larangan Ekspor Bijih Nikel Yang Berakibat Gugatan Uni Eropa Di World Trade Organization
Authors: Sihotang Erikson , Suandika I Nyoman
Published: February 2023

Indonesia saat ini sedang menghadapi gugatan Uni Eropa (UE) di Organisasi Perdagangan Dunia (WTO) terkait kebijakan pelarangan ekspor bijih nikel. Gugatan UE ini bermula dari keluarnya kebijakan pemerintah untuk melarang ekspor nikel dalam bentuk bahan baku sejak 2020. Kebijakan tersebut dinilai melanggar Pasal XI GATT tentang komitmen untuk tidak menghambat perdagangan. Indonesia masih memiliki beberapa alternatif melalui ketentuan WTO sendiri, khususnya pengecualian pada Pasal XX (g) dan juga Indonesia harus dapat memberikan bukti bahwa kebijakannya merupakan kebijakan yang tidak merugikan Uni Eropa, karena tidak hanya Indonesia yang dirugikan. produsen nikel tetapi juga negara-negara lain masih mampu memberikan pasokan ke Eropa.
Performance Analysis of Road and Bridge Planning Consultants in Highway Work in Banjarbakula
Authors: Ramadani Wahid , Prasetia Irfan
Published: February 2023

The results of planning often find errors in road handling methods and volume inaccuracies between planning and field conditions. This study aims to analyze the performance of planning consultants on indicators of planning documents, indicators of planning performance, and indicators of understanding of planning references. To determine the level of performance satisfaction used  CSI method. As for knowing the performance that must be improved or less satisfactory, the IPA method is used.
From the research results obtained based on the CSI method, Planning Document Indicators got 61.51% (Quite Satisfied), Planning Performance Indicators got 70.01% (Satisfied), and Indicators of Understanding of Planning References got 62.63% (Quite Satisfied). This study succeeded in identifying five factors that affect the performance of the planning consultant and need to be improved, namely 1) Conformity between the drawing documents, RKS, and Engineer Estimate, 2) The suitability of the type of personnel costs with project needs, 3) The suitability of the types of non-personnel costs with project needs, 4) Accuracy of data collection, and 5) The suitability of the method of calculating personnel costs with planning guidelines.
The first strategy of the consultant is to commit to using competent personnel according to the qualifications listed. The second strategy of the consultant is to review the planned site carefully. Moreover, the last strategy is for consultants to work more optimally and effectively in construction projects.
Organized Corporate Crimes using UNCITRAL Arbitration Framework Development for EPC Disclosure concerning Epistemic Corruption and Pharmaceutical Fraud of Off-label Medicines as Health Regulation and Policy
Authors: Llarena Zharama
Published: February 2023

Purpose: Corporate Governance is a conceptual framework of business designs intended to illustrate the various activities of a company towards fulfilling its profit goals as private stakeholder and contributing to public interests for social obligation of sustainable development. Disclosure of corporate social responsibility is the central mechanism of corporate governance.

Methodology: Based on stakeholder theory, corporate governance strongly influences corporate social responsibility disclosure to enhance the relationship of stakeholders and its business community.

Findings: Tax aggressiveness is utilized by board director and its members to lessen tax contribution which is contrary to the government sector goals of maximizing tax impositions for public welfare and safety. Unlawful behavior on tax aggressiveness is known as tax evasion while tax avoidance is not a violation and serves as a loophole to the taxation system, although corporate fraud is apparent in off-label medicines. UNCITRAL model law is a legal arbitration concept of making “commercial” expand to other comparable jurisdiction of international trade. The European Patent Commission is the legal authority that delineates medical policies from patented products.

Unique Contribution to Theory, Practice and Policy: This paper aims to develop arbitration framework based on stakeholder theory of corporate governance to separate tax evasion from tax avoidance as organized crime sourcing treatment of policies and engineer tax planning to divide intellectual property of product design with corporate fraud concerning off-label medicines. Therefore, tax evasion and corporate fraud are business crimes in pharmaceutical industries needed to be clearly managed by institutional healthcare companies for promoting economic success.
Entre dentes, cartas e afeto, a correspondência de Otto para Josué
Authors: Rettenmaier Miguel , Santin Bruna
Published: February 2023

A divulgação de correspondência entre escritores possui as suas justificativas afiançadas, na grande maioria dos casos, pela amizade que duas personalidades de um mesmo círculo literário cultivaram. Sendo regado por tal sentimento, a quantidade de testemunhos sobre o cotidiano, vida e obra renasce através da leitura das cartas particulares e afetivas de autores.  Para tanto, este trabalho pretende averiguar discursos no íntimo epistolar de  dois importantes escritores – Josué Guimarães e Otto Lara Resende – os quais trocaram correspondências, algumas das quais estão sob guarda do ALJOG/UPF, na Universidade de Passo Fundo. Com o objetivo da verificação da memória no diálogo íntimo missivista dos dois autores, algumas cartas serão remontadas neste trabalho com o intuito de evidenciar a amizade entre ambos, a qual deixa transparecer processos importantes de leitura e apoio, principalmente pela voz de Otto. Amparado por Santiago (2006), Diaz (2016) e Bouzinac (2016), este trabalho resgatará a voz privada e desconhecida até então na epistolografia daqueles cuja importância literária jamais será esquecida.
Memórias interioranas em Coração do Tempo, de Maria Zélia Vale de Oliveira
Authors: Almeida Ávila Deivide , Sacramento Ozana Aparecida do
Published: February 2023

Resumo: Este artigo propõe uma compreensão dos poemas da obra Coração do tempo (2020) da poeta Maria Zélia Vale de Oliveira (1941). Nos versos da poeta xaveriense, o ato de rememoração reconstrói, por meio da imaginação, as vivências da voz lírica em pequenas cidades do interior mineiro. Desvelando a natureza ilimitável da memória, a escrita de Oliveira, recompõe sua história e a coletiva num cotidiano em que a família, tradições, os habitantes de sua vila, a natureza e até seus diálogos literários constituem matéria para a criação literária em que as temporalidades se interrelacionam. Para contribuir com essa investigação, recorremos a estudos dos teóricos de Silvina Lopes Rodrigues e Jöel Candau.
Entre passados futuros:
Authors: Van Hombeeck Lucas , Botelho André
Published: February 2023

Nesta contribuição coletiva do projeto MinasMundo: o cosmopolitismo na cultura brasileira buscamos debater a maneira como as efemérides do ano 1922-2022 vêm sendo comemoradas e quais horizontes se abrem para o centenário 1924-2024, ano chave do modernismo visto desde Minas-Gerais. Discutimos o cosmopolitismo como forma de problematizar a dependência cultural, o papel da cultura brasileira no mundo e as desigualdades da geopolítica global de produção do conhecimento, entre outras.
Literatura e filosofia em "Em silêncio" de Maria Lysia Corrêa de Araújo
Authors: Condé da Cruz Iza , Pires André Monteiro  Guimarães Dias
Published: February 2023

Tendo por base as possibilidades que o encontro entre literatura e filosofia nos proporcionam, procuraremos neste artigo fazer algumas reflexões acerca dessa interdisciplinaridade a partir dos contos “Os olhos incólumes” (p. 25-29), “De muita coragem” (p. 33-39), “A mulher no mar” (p. 61-67) da obra Em silêncio da escritora mineira Maria Lysia Corrêa de Araújo (1978). Ao mesmo tempo, chamaremos atenção para aspectos em seu livro que demonstram uma grande vontade das personagens de escaparem dos moldes sociais que vivenciamos quase que naturalmente. Para essa análise, usaremos como base o pensamento dos filósofos Friedrich Nietzsche (s/a) e Gilles Deleuze (1998).
Ўзбекистон Республикаси қонунчилигида жиноят ишлари юритиладиган тил
Authors: Джураев Ихтиёр
Published: February 2023

Мақолада жиноят процессида жиноят ишлари юритиладиган тил тушунчаси ва моҳияти, Давлат тили сифатида ўзбек тилининг мамлакатимиз ҳаётида тутган ўрни, норматив-ҳуқуқий ҳужжатлар ва халқаро ҳужжатларда келтирилган она тили ва тилга оид қоидалар, миллат, жиноят ишларини юритиш жараёнида иштирок этаётган иш юритилаётган тилни билмайдиган ёки етарли даражада тушунмайдиган фуқароларнинг ҳуқуқларини таъминлашга оид масалалар илмий таҳлил қилинган ҳамда бу борада тегишли таклифлар илгари сурилган.
Method Development And Validation For The Simultaneous Estimation Of Remdesivir In Bulk And Pharmaceutical Dosage Form And Stability Studies By Uplc
Authors: Mohammed Azeemuddin , Hemant Kumar Sharma
Published: February 2023

An Easy, sensitive, specific and precise UPLC method for the pharmaceutical dose estimation of Remdesivir in tablet dosage form. Chromatogram was run through BEH (2.1 x 50mm, 1.7µm) Mobile phase containing 0.01N Kh2po4: Acetonitrile taken in the ratio 60:40 was pumped through column at a flow rate of 0.3ml/min. Buffer used in this method was 0.01N Potassium dihydrogen phosphate buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 252.0nm. Retention time of Remdesivir were found to be 1.565 min. %RSD of the Remdesivir were and found to be 0.3. %RSD of Repeatably precision of Remdesivir were found to be 0.3. %Recovery was obtained as 99.87% for Remdesivir. %Assay was obtained as 99.58% for Remdesivir. LOD, LOQ values obtained from regression equation of Remdesivir were 0.33, 1.00. Regression equation of Remdesivir is y = 22602x + 1936. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
FERRAMENTAS EDUCATIVAS SOBRE A INFLUÊNCIA DAS MÍDIAS SOCIAIS NA IMAGEM CORPORAL DE ADOLESCENTES: UMA REVISÃO INTEGRATIVA
Authors: Da Silva Livianne Gomes , Girão Saraiva de Almeida Nádia Maria
Published: February 2023

Identificar as ferramentas educativas disponíveis sobre a influência das mídias sociais na imagem corporal de adolescentes na literatura. Método: estudo de revisão integrativa realizada na PubMed, ScienceDirect, Lilacs e Medline via BVS, pelos critérios orientadores PICo; através do DECs e MeSH: mídias sociais, rede social, imagem corporal, adolescentes e educação, nos idiomas português, espanhol e inglês. Os critérios de inclusão foram: artigos completos disponibilizados na íntegra, nas bases de dados selecionadas, que apresentavam aderência à temática nos idiomas português, espanhol e inglês, publicados entre os anos de 2013 e 2022, com vistas a identificar as evidências da temática em questão publicadas nos últimos 10 (dez) anos. Resultados: a amostra incluiu 19 artigos, sendo 16 internacionais e 3 nacionais com diversas abordagens metodológicas e contextos investigativos. Os dados foram organizados conforme as categorias: influência da mídia social na imagem corporal (15 artigos) e intervenções educativas sobre essa temática (4 artigos). Conclusão: a mídia social tem contribuído para o aumento da pressão corporal. Além disso, a internalização da mídia está relacionada com a insatisfação da imagem corporal entre adolescentes do sexo feminino. Conclui-se que existe uma grande demanda por intervenções sobre imagem corporal e influência da mídia social para adolescentes. Consequentemente, há uma necessidade de ações educativas que abordam o uso de mídias sociais e preocupações com a imagem corporal entre meninas adolescentes para prevenir e minimizar danos potenciais à saúde.
Membangun Kembali Animo Wisata Akibat Pandemi Melalui Signage & Katalog Wisata DIGITAL
Authors: Murdaningsih Retno Purwanti , Andriani Yunisa Fitri , Nadia Zita
Published: February 2023

The Covid19 pandemic that hit the world at the beginning of 2020 has paralyzed the economic sector. Tourism is the earliest sector affected, with the policy of large-scale social restrictions that make the Tourism Industry suspended. Hospitality and travel businesses lost more than 50% of their income to almost out of business. Breakthroughs and innovations are needed to stay afloat from covid hurricane 19. This writing aims to find alternatives to re-increase public interest to return to safe tourism activities without violating WHO health protocols. The method used is a qualitative method based on observations and observations, the outcome of this activity is in the form of a prototype signage and a tourism catalog that can be applied directly to the tourism industry. Conclusions while the tourism industry can still be run as long as it can meet safe health protocols in the new normal approach.
Pemanfaatan E-Commerce dalam Pemasaran Hasil Pertanian di Kelurahan Teratai Kabupaten Batang Hari
Authors: Erwandri Epit , Harimurti Sri , Rusnani Rusnani , Enita Enita
Published: February 2023

In the current era of information technology, information technology has helped and facilitatedhuman life from various dimensions. One of the products of the very rapid development ofinformation technology is E-commerce. E-commerce is a means or place to buy and sell goods,services and information via the internet network on computers or other electronic means. Ecommerce(Electronic Commerce) can be used in marketing agricultural products and has had amajor influence on the growth of the social and economic order of society. The purpose of thisservice is so that farmers who are in the Teratai village of Batang Hari Regency can increase theirknowledge of marketing agricultural products through E-Commerce, and train participants tomarket their agricultural products through E-Commerce and provide real time price information.The method used is counseling and training activities. The results of this service activity are toprovide benefits for training participants in increasing their knowledge and skills for businessdevelopment through the use of marketing agricultural products using E-Commerce. By marketingproducts through E-Commerce, it is hoped that in the future the business carried out by them will bemore developed, and the sales volume of agricultural products will increase in a fast time.
Penerapan Cat dalam Mengukur Tingkat Kesiapan Siswa SMK dalam Menghadapi Ujian Masuk Perguruan Tinggi
Authors: Hadi Aulia Fitrul , Gusrion Deval , Andrianof Harkamsyah , Putra Okta Andrica
Published: February 2023

Technology is one of the developments in education in the world, including in utilizing technology in the world of education. Senior high school national exams and their equivalents make use of technology in their implementation. however, the use of technology has not been mastered by students in Indonesia. it is necessary to carry out a simulation in facing the national exam. This community service provides facilities for partners in conducting trials to take the national exam. multimedia applications provide an interactive effect between students and computers. which makes it easier for students to understand the meaning of the questions given on the exam.
Kampanye Penggunaan dan Pembagian Masker Sebagai Upaya Pencegahan Penularan Covid 19 di Pasar Landungsari Malang
Authors: Subhi Misbahul , Rupiwardani Irfany
Published: February 2023

Currently, public awareness to use masks has begun to loosen, and people tend to ignore health protocols when doing activities outside the home, one of which is when shopping at the market, because we want to raise public awareness about the importance of implementing health protocols to prevent the spread of Covid 19 through the campaign. use and distribution of masks. The results obtained during this activity were traders who were very enthusiastic about asking about Covid, traders who asked for masks more than rations, and masks that were all used up and this activity received support from market managers well. The conclusion is that activities depend on assumptions, but there is still a need for continuous guidance and supervision by involving related parties.
Pemberdayaan Masyarakat dalam Berwirausaha Produk Hasil Pertanian Dimasa Pendemi Covid 19
Authors: Rusnani Rusnani , Harimurti Sri , Erwandri Epit , Enita Enita
Published: February 2023

The Covid 19 pandemic that occurred in Indonesia since the beginning of March 2020, resulted in several business activities being suspended, mass layoffs, decreased people's income, and the people's purchasing power for goods also decreased. Based on the results of the analysis of The Economist Intelligence Unit (EIU) in April 2020, it shows that the growth of the manufacturing sector was 3.0% to -1.5% (corrected -4.5%) and the service sector 7.2% to 2.4% (corrected -4.8%), sector growth agriculture was only revised from 4.1% to 3.2% (corrected-0.9%). This shows that the Covid 19 pandemic has the least impact on businesses in the agricultural sector so that entrepreneurial opportunities in the agricultural sector are still large. In the Teratai village, Muara Bulian district, Batang Hari Regency, Jambi Province, most of the entrepreneurs owned by the residents are processed agricultural products in the form of snacks such as various cakes, chips, bread, and side dishes. Through community service activities in the form of counseling and assistance for entrepreneurial management, it can encourage people to develop businesses and manage a business with good management. The survey results showed that 66.67% experienced a decrease in demand for products offered during the Covid 19 pandemic and 33.33% demand for products offered remains the same as before the Covid 19 pandemic. The causes of decreased demand among others are a lack of knowledge of changes in consumer behavior, limited space due to the Covid 19 pandemic, and a lack of technological knowledge to market products.
Digital Komunikasi Untuk Kegiatan Organisasi Remaja Mesjid
Authors: Firdalius Fitri , Djesmedi Dinda , Zalmi Wahyuni Fithratul
Published: February 2023

Due to the current state of the COVID-19 pandemic, it is necessary to practice social distancing. The use of digital communication is needed, therefore we can use digital communication in mosque youth activities, especially the Jamiek Mosque Youth Organization. With this digital communication technology, we can communicate indirectly or face to face with someone or many people with whom we will communicate. The purpose of this paper is to provide information and implementation in the use of digital communication. Based on this goal, utilizing social media such as Whatsapp, Facebook, Instagram, Google Meet, and others to support the activities of mosque youth. The results show that digital communication can maximize mosque youth activities, facilitate long-distance communication, obtain remote information, reduce costs, and shorten time.
Upaya Pemberdayaan Wirausaha Disabilitas Fisik
Authors: Tjahjanti Prantasi Harmi , Arrahman Rizki Ardi , Putra Abdi Chandra
Published: February 2023

Community Service (Abdimas) this paper presents empowerment efforts for physical disabilities in the independent age category where they have their own entrepreneurs. There are 15 people who live in Surabaya and Sidoarjo, with the same problem, namely to improve their entrepreneurship. The first is the empowerment effort by providing a business capital loan of one million rupiah which will be returned five times. The form of the loan does not use interest, so it is not usurious, the second is taking care of the legality of their entrepreneurship, namely the Business Identification Number (NIB) for free, so that their entrepreneur is licensed/legally, and the third is giving donations in the form of basic necessities. All of this assistance is evaluated for three months to see the results. The results obtained from capital loans provide continuity of their entrepreneurship, although not high, the value of income from their business has increased by up to 15%. Meanwhile, the NIB they received was a 'weapon' as a license to do business. Meanwhile, basic food assistance can help their lives with the current condition of rising prices.
Pelatihan Pemilihan Daging Ayam Sehat Layak Konsumsi Sebagai Upaya Pencapaian SDGS di Desa Balumbang Jaya
Authors: Ayuningtyas Gilang , Priyambodo Danang , Husyairi Khoirul Aziz
Published: February 2023

SDGs Desa is a sustainable development role that would be included in the priority program for using the Village Fund in 2021. Based on the results of the mapping of SDGs in 12 villages around the IPB University, especially in Balumbang Jaya, Bogor, the goals of ending hunger or eliminating hunger, achieving food security, and good nutrition, and increasing sustainable agriculture (the SDGs No 2), are still lacking. Based on this situation, it is necessary to make efforts to alleviate these problems and encourage the achievement of SDG Goal No 2. Community service program, Pelatihan Pemilihan Daging Ayam Sehat Layak Konsumsi sebagai Upaya Pencapaian SDGs di Desa Balumbang Jaya, aims to provide solutions based on academic studies, challenges, or problems that people in Balumbang Jaya Village face, with a focus on the SDGs No 2 through counseling and training. The method used is a direct presentation, discussions, filling out surveys, and participatory activities through the practice of making dishes from fresh and frozen chicken meat. This community service program concludes that there is an increase in knowledge about the selection of Aman, Sehat, Utuh, Halal  (ASUH) chicken meat, as well as changes in participants' perceptions about frozen chicken meat.
Pelatihan Peningkatan Asupan Protein, Kalsium dan Antioksidan Melalui Pemberian Cookies Berbahan Ceker Ayam dan Daun Kelor
Authors: Andriani Eka , Kurniasari Ratih , Supriadi Devie Rienzani , Nuraeni Ani
Published: February 2023

During the Covid-19 pandemic, people began to take better care of their health by consuming nutritious food. Cookies are one of the most popular types of snacks wich we can easily to find it wherever and whenever now. There are many kinds of cookies sells in the market by offering flavors and variants, but no one has offered cookies by adding animal ingredients and fiber that can increase the nutritional content for their product. One of the ingredients that can be added in making cookies is chicken claws and moringa leaves which are made into flour before. The addition of chicken claws flour and moringa leaves is expected to increase the selling value and can utilize local food from underutilized ingredients but have high nutritional content such as protein, calcium and antioxidants. The research products in the form of claw cookies and moringa leaves have been tested in the IPB laboratory and tested organoleptically on semi-trained panelists. In addition, "celor cookies" were also distributed to local residents as a form of community service. Community service activities are also carried out through educational webinars on the use of claws and moringa leaves which include hundreds of participants and are assisted by several students.
The Bloomsbury Handbook of Technology Education
Authors: Gill David , Irving-Bell Dawne , McLain Matt , Wooff David
Published: February 2023

The Bloomsbury Handbook of Technology Education draws together international perspectives on contemporary praxis in technology education from philosophy to empirical research. Through carefully commissioned chapters, leading authors explore the fundamentals of technology education, curriculum and pedagogy. Chapters discuss technology education as it can be experienced by children and young people, inside and outside of the classroom, across the world, as well as the importance of technology and the history and philosophical origins of technology education. Carefully curated, this is an innovative and exciting volume for students, teachers, teacher educators, researchers, lecturers and professors in technology education.
Feminist Futures of Work: Reimagining Labour in the Digital Economy
Authors: Arora Payal , Raman Usha , König René
Published: February 2023

 The future of work is at the centre of debates related to the emerging digital society. Concerns range from the inclusion, equity, and dignity of those at the far end of the value chain, who participate on and off platforms, often in the shadows, invisible to policymakers, designers, and consumers. Precarity and informality characterize this largely female workforce, across sectors ranging from artisanal work to salon services to ride hailing and construction. A feminist reimagining of the futures of work—what we term as “FemWork” —is the need of the day and should manifest in multiple and various forms, placing the worker at the core and drawing on her experiences, aspirations, and realities. This volume offers grounded insights from academic, activist, legal, development and design perspectives that can help us think through these inclusive futures and possibly create digital, social, and governance infrastructures of work that are fairer and more meaningful. 
An Entity Registry: A Model for a Repository of Entities Found in a Document Set
Authors: Bellandi Valerio , Siccardi Stefano
Published: February 2023

This paper proposes a conceptual structure for a repository of entities that can be found by usual procedures of Natural Language Processing, that is the search for entities mentioned in text, their identification, possibly through the link to entries in Background Knowledge Basis (BKG) and theconstruction of a Knowledge Basis or Graph to host the information found in this process. We address applications where a BKG is of little help, because the involved entities are not so relevant to be included in any, being for instance ordinary people or small companies. Therefore, we rely on the entities’ attributes and relationships for unique identification, disambiguation, knowledge checking and any other relevant operation. One of the final goals achieved by the proposed method is the ability to merge knowledge collected in separate bases, once they are referred to the same Entity Registry.