bluuebunny/crossref_metadata_2025 huggingface dataset:
The acquisition of clinically relevant amoxicillin resistance in Streptococcus pneumoniae requires ordered horizontal gene transfer of four loci
Authors: Gibson Paddy S. , Bexkens Evan , Zuber Sylvia , Cowley Lauren A. , Veening Jan-Willem
Published: July 2022

Understanding how antimicrobial resistance spreads is critical for optimal application of new treatments. In the naturally competent human pathogen Streptococcus pneumoniae, resistance to β-lactam antibiotics is mediated by recombination events in genes encoding the target proteins, resulting in reduced drug binding affinity. However, for the front-line antibiotic amoxicillin, the exact mechanism of resistance still needs to be elucidated. Through successive rounds of transformation with genomic DNA from a clinically resistant isolate, we followed amoxicillin resistance development. Using whole genome sequencing, we showed that multiple recombination events occurred at different loci during one round of transformation. We found examples of non-contiguous recombination, and demonstrated that this could occur either through multiple D-loop formation from one donor DNA molecule, or by the integration of multiple DNA fragments. We also show that the final minimum inhibitory concentration (MIC) differs depending on recipient genome, explained by differences in the extent of recombination at key loci. Finally, through back transformations of mutant alleles and fluorescently labelled penicillin (bocillin-FL) binding assays, we confirm that pbp1a, pbp2b, pbp2x, and murM are the main resistance determinants for amoxicillin resistance, and that the order of allele uptake is important for successful resistance evolution. We conclude that recombination events are complex, and that this complexity contributes to the highly diverse genotypes of amoxicillin-resistant pneumococcal isolates.
Advances on water quality modeling in burned areas: A review
Authors: Basso Marta , Serpa Dalila , Mateus Marcos , Keizer Jacob Jan , Vieira Diana Catarina Simões
Published: July 2022

Wildfires are a recurring hazard in forested catchments representing a major threat to water security worldwide. Wildfires impacts on water quality have been thoroughly addressed by the scientific community through field studies, laboratory experiments, and, to a lesser extent, the use of hydrological models. Nonetheless, models are important tools to assess on-site and off-site wildfires impacts and provide the basis for post-fire land management decisions. This study aims to describe the current state of the art of post-fire model adaptation, understanding how wildfires impacts are simulated and the options taken by the modelers in selecting parameters. For this purpose, 42 publications on modeling wildfire impacts on the hydrologic cycle and water quality were retrieved from the SCOPUS database. Most studies simulated post-fire hydrological and erosion response in the first year after the fire, while few assessed nutrients changes and long-term impacts. In addition, most simulations ended at the watershed outlet without considering the fate of pollutants in downstream waterbodies. Ash transport was identified as a major research gap, given the difficulties of its incorporation in the current models’ structure and the high complexity in predicting the heterogeneous ash layer. Including such layer would improve models’ ability to simulate water quality in post-fire conditions, being ash a source of nutrients and contaminants. Model complexity and data limitations influenced the spatial and temporal scale chosen for simulations. Post-fire model adaptations to simulate on-site soil erosion are well established, mainly using empirical equations extensively calibrated in the literature. At the watershed level, however, physical and process-based models are preferred for their ability to simulate more complex burned area characteristics. Future research should focus on the simulation of the ash transport and the development of integrated modelling frameworks, combining watershed and aquatic ecosystem models to link the on and off-site impacts of fires.
Drive Type Virtual Reality - Head Mounted Display
Authors: ogata yoichi
Published: July 2022

I realized the high-power drive type of emission beam generated at the surface by using the excitation of the guided mode in a TiO
2 slanted nanograting layer. In the TiO
2 layer, the beam is waveguided along the short axis direction of the grating at a specific injection angle Θ. On the surface of the layer, a beam consisting of leakage generated during the waveguide is emitted. The emitted beam would have a high optical intensity compared with the general emission. Furthermore, it would generate an afterimage for the waveguide direction. In this work, I performed angle-resolved measurements to obtain two effects, namely intensity maintain and after(-driving) imaging. Subsequently, I identified an appropriate resonance condition for the above radiation on the 1D waveguide on the surface. Thereby, the resonance peak for the waveguide with Θ
FWHM =10.0° at Θ = 10° was verified in the measurement. This grating sample is likely to be effective as a novel coupler on a binocular Virtual Reality – Head Mounted Display (VR-HMD).
Elevating Black Pregnant Voices for Self-Advocacy
Authors: Wicks Tiffany
Published: July 2022

Black women have the highest rate of maternal mortality in the United States. Racism, access to health care, lack of quality health care providers, and lack of childbirth and advocacy education are contributors to maternal mortality. Systemic and interpersonal racism significantly impact health experiences of pregnant women. Lack of access to health care and lack of quality health care providers can prevent pregnant women from receiving adequate care and keep their health concerns from being taken seriously. Childbirth education can prepare pregnant women for birth; and advocacy education can help patients understand their rights and how to collaborate in their care, especially for high-risk populations such as pregnant women. Because Dallas has a high maternal mortality rate, this study explores the experiences and impact for Black pregnant women after attending a childbirth and advocacy education course. The findings indicate that when Black pregnant women know their rights, confidence to advocate for birth is increased, and support teams can help ensure rights are respected in birth.
Plausible Futures of Socialized Risk: Integral Sustainability or Globalized Dystopia?
Authors: Masters-Gonzales Jodi
Published: July 2022

Contemporary corporate and governance structures do not go far enough to protect the public against the socialization of market risks—particularly during states of globalized crises occurring with increased frequency. While many have written about these problematic structures, this article introduces a novel concept of “transunity,” the desired state of a globalized ecosystem that continuously leverages its collective intelligence in harmonious knowledge production and innovation to achieve a shared strategic vision of integral sustainability. This article also describes the required leadership capacity of State and institutional actors capable of leading such an incredible movement of change. What is transunity? Simply put, it is a state of harmonious, yet sovereign, sustained globalized cooperation. The “blue moon” opportunity for transunity arises amid rare catalyzing events that compound existential risks in the short- and long-term, producing a level of destabilization so great, that only a dystopian future is plausible. The key element for producing a transformative outcome is a shared vision extending beyond what is currently known and seen as possible. This article has three goals: First, to explain the current state and its prevailing root causes, highlighting the failure of the current neoliberal system. Second, to introduce and define the concept of transunity, a novel, complex state of harmony enabled in a globalized system of governance whose optimal performance increases with heterogeneity. Finally, the article examines plausible challenges at the edge of chaos—the phase of forming transunity—and the culturally diverse leadership and institutional fortitude required to move into harmonious complexity and actualization of the moonshot vision.
Diabetes mellitus and heart failure — a modern look at the mechanisms of development
Authors: Svarovskaya A. V. , Garganeeva A. A.
Published: July 2022

Heart failure (HF) is a pressing public health problem. According to the literature, the presence of diabetes mellitus (DM) significantly increases the risk of repeated hospitalizations and the length of hospital stay in patients with heart failure. The proportion of HF remains high due to increased life expectancy, higher prevalence of risk factors and improved survival rates. Currently, advances in the treatment of coronary heart disease (CHD) and valvular disease have significantly improved survival rates, but the prognosis for heart failure remains extremely poor. Among the most important medical problems, heart failure occupies a special place in patients with type 2 diabetes. DM contributes to the onset of HF through a variety of mechanisms, including a complex of specific structural, functional, and metabolic changes in the myocardium called diabetic cardiomyopathy. Despite the active study of the causes of cardiomyopathy, the search and implementation of new approaches in assessing the risk of developing this pathological phenomenon in patients with heart failure remains relevant. This review examines current hypotheses for the development of diabetic cardiomyopathy, such as insulin resistance, endothelial dysfunction, fibrosis, lipotoxicity, and energy disorders.
Practical aspects of initiation and use of SGLT2 inhibitors: inpatient and outpatient perspectives
Authors: Salukhov V. V. , Galstyan G. R. , Ilyinskay T. A.
Published: July 2022

In today`s therapy of type 2 diabetes mellitus, SGLT2 inhibitors have taken their rightful place both due to their positive hypoglycemic and outstanding cardiorenometabolic effects. Recent randomized clinical trials, such as DAPA HF, EMPEROR-Reduced and EMPEROR-Preserved, show the benefits of their use in the treatment of patients with chronic heart failure without regard to the status of type 2 diabetes mellitus and so significantly expands the range of use of SGLT2 in the practice of doctors of various specialties. This review presents not only the results of the most significant studies of SGLT2 inhibitors, but also the main approaches to the starting therapy with this class of drugs in various clinical situations, both inpatient and outpatient. In addition, potential adverse events and limitations associated with the use of SGLT2 inhibitors are discussed in detail, which must be taken into account when prescribing in particular patient. The practical aspects of SGLT2 inhibitors` prescription are considered separately through the prism of their safe use in the perioperative and postinfarction periods, as well as during other special conditions. Particular attention is paid to the monitoring of physical and general examination data and laboratory instrumental tests, the consideration of which will minimize adverse events and best benefit for many cardiological, endocrinological and nephrological patients.
Structurall features of the pancreas in patients with type 1 diabetes mellitus
Authors: Ragimov M. R. , Nikonova T. V. , Babaeva D. M. , Vladimirova V. P. , Shestakova M. V.
Published: July 2022

BACKGROUND: Observation of changes in the volume and size of the pancreas has a long history, however, the results of studies are still not unambiguous, the specific causes of changes in pancreatic volume, as well as their consequences, are not clear. According to some data, the decrease of pancreas volume in life expectancy is 35–45% in the population of patients with a long history of type 1 diabetes, and about 20–25% during the first year of the disease. Interestingly, in T1D in 20–45% of cases, the development of exocrine pancreatic insufficiency is noted, one of the manifestations of which is pancreatic atrophy, leading to a decrease in life expectancy.

AIM: Assess the volume and size of the pancreas, as well as factors that can influence on their changes.

MATERIALS AND METHODS: The study included 78 patients with type 1 diabetes mellitus, the control group consisted of 23 people without previously identified disorders of carbohydrate metabolism, comparable in age and anthropometric parameters with the study group. RESULTS: The volume and dimensions of the pancreas were statistically significantly less in patients with T1D than in the control group. In addition, the influence of the duration of T1D and the age of onset of the disease on these indicators has been proven.

CONCLUSION: The volume and size of the pancreas in patients with T1D is less than in healthy individuals. It is necessary to  study the effect of these changes on the function of the pancreas.
Pravni položaj suvlasnika u odnosu na cijelu stvar
Authors:   International Burch University, Oruč Esad
Published: July 2022

U suvlasničkoj zajednici stvar pripada svim suvlasnicima zajedno, tako da zbir dijelova prava pojedinih suvlasnika čini cjelovito pravo vlasništva na stvari. Upravo zbog ovog specifikuma suvlasničke zajednice, izvršavanje vlasničkih prava zavisi od zajedničke volje svih suvlasnika, tako da čak ni u slučaju kada, prema slobodnoj objektivnoj ocjeni nekog od suvlasnika određena radnja ide u prilog svim suvlasnicima, ona ne može biti poduzeta samoinicijativno-iz čega slijedi da su prava pojedinih suvlasnika ograničena istim tim pravima drugih suvlasnika. Dakle, svakom suvlasniku pripadaju sva vlasnička ovlaštenja –potpuno u pogledu idealnog dijela, a u pogledu cijele stvari ograničeno - u omjeru visine njegovog suvlasničkog dijela. Slijedom navedenog, izvršavanje vlasničkih prava glede cijele stvari u većini slučajeva mora biti uz saglasnost svih suvlasnika. S obzirom na to da se radi o vrlo složenom odnosu, koji predstavlja jedinstvo suprotnosti zajedničkog i individualnog elementa suvlasništva, u nastavku rada ćemo detaljno izložiti pravni položaj suvlasnika u odnosu na cijelu stvar.
Nastanak i razvoj neposredne demokratije sa osvrtom na medije kao jedan od odlučujućih faktora u neposrednom odlučivanju
Authors:   University of Tuzla, Čizmić Aida , Čizmić Mirsad
Published: July 2022

Autori u radu razmatraju prve pojavne oblike neposredne demokratije, koji su postali okusnica u daljem razvoju neposrednog učešća građana u javnom upravljanju. Demokratija modernog doba je kombinacija neposredne i predstavničke demokratije, gdje je referendum najprisutniji instrument direktne demokratije, dok se predstavnička demokratija realizuje kroz postojanje parlamenta ili drugog političkog organa, kao najvišeg zakonodavnog tijela u jednoj državi.Autori će pokušati, da na jedan sistematičan način, ukažu na važnost i zanačaj postojanja prava na neposredno odlučivanja, kao jednog od naboljih mehanizama kontrole u modernom konceptu države.
Influence of Renewable Fuels and Nanoparticles Additives on Engine Performance and Soot Nanoparticles Characteristics
Authors: Fayad Mohammed A. , Abed Azher M , Omran Salman H , Jaber Alaa Abdulhady , Radhi Amerah A , Dhahad Hayder A , Chaichan Miqdam T , Yusaf Talal
Published: July 2022

The fuel combustion in diesel engines can be improved by adding nanomaterials to the fuel which result in an reduction in pollutant emissions and enhance the quality of fuel combustion. The engine performance and soot nanoparticles characteristics were evaluated in this study with adding nanoparticles of copper oxide (CuO2) to the rapeseed methyl ester (RME) and diesel under variable engine speeds. The addition of CuO2 to the RME significantly improve brake thermal efficiency (BTE) and decline the brake specific fuel consumption (BSFC) by 23.6% and 7.6%, respectively, compared to the neat RME and diesel fuel. The inclusion CuO2 nanoparticles into the RME and diesel led to decrease the concentration and number of particulate matter (PM)by 33% and 17% in comparison with neat RME and diesel without nano additives, respectively. Moreover, PM is significantly decreased by 31.5% during the RME combustion in comparison with neat RME and diesel under various engine speeds. It was also obtained that the number of emitted particles (npo) reduced by 23.5% with adding nanoparticles to the RME in comparison with diesel, while the diameter of soot nanoparticles (dpo) increased by 8.6% in comparison with diesel. Furthermore, the addition CuO2 to the RME decreased the size and number of particles more than to the diesel fuel.
Real-time control of laboratory information system based on nonlinear programming
Authors: Lv Fei , Yu Junfang
Published: July 2022

In order to study the real-time control research of laboratory information system based on nonlinear programming, by analyzing the role played by the laboratory information management system (LIMS) in quality management, and the relationship with quality control, put forward the functions that LIMS should set up and possess in the management of controlled documents, processing of inspection data, etc., an accurate and reliable method to ensure the test results. It has been verified that the system can meet the performance requirements of 350 virtual concurrent users, its memory usage and CPU usage are within acceptable limits, the response time of important operations of each module of the system is within 3 s. The average memory consumption obtained from the test is 2.02 GB, and the average utilization rate of CPU is 66%. The two indicators basically meet the performance requirements of the system. The system can meet the performance requirements of the number of virtual concurrent users 350, both its memory occupancy and CPU utilization rate are in the acceptable range. It not only improves the accuracy of the sample processing results, but also reduces the labor intensity of the technicians, so that the laboratory expands the analysis function from the simple reporting function.
Tra gli Inferi e le stelle: un problema testuale nel mito di Orfeo in Virgilio (georg. 4,509) e il Leitmotiv astronomico nelle catabasi da Omero a Dante (con echi di Apollonio Rodio)
Authors: Boldrer Francesca
Published: July 2022

The article treats the presence of stars in terrestrial landscapes, in opposition to the Underworld and in connection to the topos of katabasis, above all in order to pursue in more depth a textual problem in the fabula Orphei of Vergil’s Georgics (4,509 astris / antris). The philological question is approached both on the basis of context and in relation to the descent into Hades of Aeneas, as well as in diachronic comparison with the earlier Homeric katabasis of Odysseus and the later otherworldly voyage of Dante in the Commedia. This internal and intertextual investigation reveals multiple functions of the celestial bodies in similar stories, as well as analogies between Homer, Vergil and Dante, linked by interests in nature and astronomy and by reciprocal influences. In fact, the Greek model and the Italian emulator seem to help clarify the contested passage in the Vergilian katabasis of Orpheus, while the Latin poet and Dante (who also share echoes of Apollonius Rhodius) rework a celestial detail already present in the νέκυια of Homer. Finally, both these classical authors, as well as Ovid, are subtly present at the ends of the three parts of the Commedia, each of which closes with the suggestive and symbolic image of “stars”, which evokes and renews an ancient tradition.
A New Emendation for matavitatau in Petronius’ Satyricon
Authors: Boggio Tiziano
Published: July 2022

In this paper I propose an emendation for a long-standing textual problem in the Satyricon. In the Cena Trimalchionis one of the freedmen, Niceros, recounts a bizarre story, culminating in a frightening encounter between him and a werewolf. In a desperate attempt to escape peril, Niceros draws his sword to repel horrific shadows and utters a sequence of eleven letters which has puzzled scholars for more than a century: matavitatau (Petron. Sat. 62.2). I propose a correction which hypothesizes the presence of a verb and an interjection, namely gladium strinxi et

matavi – tatae! –

umbras cecidi. I support my proposal by analyzing the intersections between literary genres and poetic texts in the Satyricon. After analyzing the meanings and nuances of tatae, I argue that the presence of such an exclamation is perfectly suitable for the situation of fear and danger that Niceros is experiencing. I suggest that Homer’s Odyssey and Vergil’s Aeneid offer decisive indications to make the presence of an interjection plausible. Niceros’ dreadful encounter with the werewolf recalls epic models, namely the descent of Odysseus and Aeneas into the Underworld. Finally, I suggest that Petronius portrays Niceros as a mythomaniac narrator who fails to appropriate the conventions of Latin and Greek epic poetry.
Arousal/Stress Effects of “Overwatch” eSports Game Competition in Collegiate Gamers
Authors: Kraemer William J. , Caldwell Lydia K. , Post Emily M. , Beeler Matthew K. , Emerson Angela , Volek Jeff S. , Maresh Carl M. , Fogt Jennifer S. , Fogt Nick , Häkkinen Keijo , Newton Robert U. , Lopez Pedro , Sanchez Barbara N. , Onate James A.
Published: July 2022

Kraemer, WJ, Caldwell, LK, Post, EM, Beeler, MK, Emerson, A, Volek, JS, Maresh, CM, Fogt, JS, Fogt, N, Häkkinen, K, Newton, RU, Lopez, P, Sanchez, BN, and Onate, JA. Arousal/stress effects of “Overwatch” eSports game competition in collegiate gamers. J Strength Cond Res 36(10): 2671–2675, 2022—To date, no physical response data are available for one of the most popular eSport games, Overwatch. The purpose of this investigation was to describe the stress signaling associated with competitive Overwatch play and to understand how acute hormonal responses may affect performance. Thirty-two male college-aged gamers (age: 21.3 ± 2.7 years; estimated time played per week: 18 ± 15 hours) completed the study. Subjects were randomly assigned to a 6-player team to compete in a tournament-style match. Salivary measures of cortisol and testosterone were collected immediately before (PRE) and after (POST) the first-round game, with the heart rate recorded continuously during the match. The mean characteristics were calculated for each variable and comparisons made by the skill level. Significance was defined as p ≤ 0.05. There were no differences in measures of salivary cortisol. A differential response pattern was observed by the skill level for testosterone. The low skill group displayed a significant increase in testosterone with game play (mean ± SD, testosterone PRE: 418.3 ± 89.5 pmol·L−1, POST: 527.6 ± 132.4 pmol·L−1, p < 0.001), whereas no change was observed in the high skill group. There were no differences in heart rate characteristics between skill groups. Overall, the average heart rate was 107.2 ± 17.8 bpm with an average max heart rate of 133.3 ± 19.1 bpm. This study provides unique physiological evidence that a sedentary Overwatch match modulates endocrine and cardiovascular responses, with the skill level emerging as a potential modulator.
Assessing the Relationship Between External Workloads and Noncontact Injuries During Summer Conditioning and Preseason Practice in National Collegiate Athletic Association Division 1 Football Players
Authors: Burghardt William P. , Pfeiffer Karin A. , Kuenze Chris
Published: July 2022

Burghardt, WP, Pfeiffer, KA, and Kuenze, C. Assessing the relationship between external workloads and noncontact injuries during summer conditioning and preseason practice in National Collegiate Athletic Association Division 1 football players. J Strength Cond Res 37(4): 816–822, 2023—The purpose of this study was to prospectively investigate the relationship between noncontact injuries and workload in collegiate football during summer conditioning and preseason training. Workload and noncontact injury data were collected over the summer conditioning and preseason practice periods for a Division 1 National Collegiate Athletic Association football team (n = 34). Seven- and 21-day exponentially weighted moving averages (EWMA) were calculated daily for each athlete. The acute:chronic ratio (A:C ratio) of these 2 measures was also calculated daily. Injury rates for noncontact injuries were calculated for both periods. Continuous variable modeling (panel logistic regression and restricted cubic spline) was used to assess the relationship of EWMA A:C ratio and noncontact injury using a 3-day lag period. Athletic exposures (AEs) were defined as individual sport training, practice, or competition sessions. Nine injuries were observed (6.97/1,000 AEs), with 4 injuries resulting in lost time (3.09/1,000 AEs). The mean EWMA A:C ratio was 0.92 ± 0.41 (95% confidence interval: 0.03–2.09). Both the panel logistic regression and the restricted cubic spline models showed a significant relationship between EWMA A:C ratio and noncontact injuries. However, the odds ratio (14.16) in the logistic regression had a very large standard error (14.51) and a wide 95% confidence interval (1.90–105.49). The restricted cubic spline model had a pseudo R
2 of 0.136. Injury occurrence at given EWMA ratio values was lower than reported in previous research. Although both continuous models demonstrated a significant relationship between the EWMA A:C ratio and subsequent noncontact injuries over the next 3 days, neither model had sufficient goodness of fit to warrant adoption at this time.
Cobogó and the Coloniality of the Brise-Soleil
Authors: Lara Fernando Luiz
Published: July 2022

The architectural forms associated with the aesthetic phenomenon that has come to be known as mudéjar and visual elements tied to Iberian and Islamic architectural traditions more broadly have been interpreted across modern Latin America in various modes. A wide array of buildings spanning from the colonial era into the twentieth century engage with this architectural legacy and distinctly stand out within the urban fabric of the continent’s major capitals today. Whether reflected in the intricately geometric woodwork of colonial-era ceilings known as carpentería de lo blanco or via the mashrabiya-inspired screened breezeways that punctuate modern Brazilian pavilions, such architectonic techniques and design criteria evoke imaginaries tied to South America’s colonial past via references to an Ibero-Islamic aesthetic. Recent calls to reexamine diverse historiographic and architectonic interpretations of the so-called mudéjar or other revivalist forms associated with the Islamic world in Latin America, along with their connections to nationalism and orientalism, invite a critical reconsideration of these constructions from a decolonial perspective within this regional context. Responding to these inquiries, this dialectical collection of essays spans diverse geographies and periods to expand upon contemporary interrogations of modern historiographic and design interpretations of the built forms associated with the mudéjar and Ibero-Islamic architectural traditions in modern Latin America. Together, they present fresh case studies and perspectives while asserting that a strategic reading of the stylistic phenomenon and its architectural echoes in Latin America is not simply the result of an external influence in the region but part of a broader complex discourse of modernity.
Bloodstained
Authors: Loftus Corey
Published: July 2022

Teresa Margolles subverts the epistemic hierarchy of the archive. Her work privileges and affirms embodied memory and material meaning as essential modes for knowing, understanding, and documenting social violence. Margolles invests her concern for societal injustice through her use of bodily fluids derived from actual human corpses. Specifically, in the textile, Sutura—a work arising out of Margolles’s research at the Venezuelan-Colombian border during the migration crisis—the artist and her collaborators commemorate the life of a murdered migrant in material and method. Embroidery is utilized as a historically coded artistic form that resembles suturing and links the project with the reparative action of sewing. Using the stark and minimal representation of a straight line, embroidery is a metaphor for the narrative lines of millions of Venezuelans who have fled the country in the last decade. Similarly, the bodily material integrated into the bloodstained cloth functions to conflate textile, skin, and landscape to explore the confluence of substance, body, and place. I argue that Margolles configures a solution to the hegemony of the archive and the approach to bodily violence in Latin America more broadly. Her archival alternative and use of corpses and bodily fluids may be gruesome and ethically questionable, but the works are also reminders of the perpetual acts of violence inflicted on forgotten bodies.
Modernizing the Mexican Bajío through Mudéjar
Authors: Loredo-Cansino Reina
Published: July 2022

The architectural forms associated with the aesthetic phenomenon that has come to be known as mudéjar and visual elements tied to Iberian and Islamic architectural traditions more broadly have been interpreted across modern Latin America in various modes. A wide array of buildings spanning from the colonial era into the twentieth century engage with this architectural legacy and distinctly stand out within the urban fabric of the continent’s major capitals today. Whether reflected in the intricately geometric woodwork of colonial-era ceilings known as carpentería de lo blanco or via the mashrabiya-inspired screened breezeways that punctuate modern Brazilian pavilions, such architectonic techniques and design criteria evoke imaginaries tied to South America’s colonial past via references to an Ibero-Islamic aesthetic. Recent calls to reexamine diverse historiographic and architectonic interpretations of the so-called mudéjar or other revivalist forms associated with the Islamic world in Latin America, along with their connections to nationalism and orientalism, invite a critical reconsideration of these constructions from a decolonial perspective within this regional context. Responding to these inquiries, this dialectical collection of essays spans diverse geographies and periods to expand upon contemporary interrogations of modern historiographic and design interpretations of the built forms associated with the mudéjar and Ibero-Islamic architectural traditions in modern Latin America. Together, they present fresh case studies and perspectives while asserting that a strategic reading of the stylistic phenomenon and its architectural echoes in Latin America is not simply the result of an external influence in the region but part of a broader complex discourse of modernity.
Optogenetic control of YAP cellular localisation and function
Authors: Toh Pearlyn J Y , Lai Jason K H , Hermann Anke , Destaing Olivier , Sheetz Michael P , Sudol Marius , Saunders Timothy E
Published: July 2022

YAP, an effector of the Hippo signalling pathway, promotes organ growth and regeneration. Prolonged YAP activation results in uncontrolled proliferation and cancer. Therefore, exogenous regulation of YAP activity has potential translational applications. We present a versatile optogenetic construct (optoYAP) for manipulating YAP localisation, and consequently its activity and function. We attach a LOV2 domain that photocages a nuclear localisation signal (NLS) to the N‐terminus of YAP. In 488 nm light, the LOV2 domain unfolds, exposing the NLS, which shuttles optoYAP into the nucleus. Nuclear import of optoYAP is reversible and tuneable by light intensity. In cell culture, activated optoYAP promotes YAP target gene expression and cell proliferation. Similarly, optofYap can be used in zebrafish embryos to modulate target genes. We demonstrate that optoYAP can override a cell's response to substrate stiffness to generate anchorage‐independent growth. OptoYAP is functional in both cell culture and in vivo, providing a powerful tool to address basic research questions and therapeutic applications in regeneration and disease.
Inventory lists of library collections as a source for the history of books, with special focus on the collection of Nikola Pavlov Gundulić from 1469
Authors: Stipčević Aleksandar
Published: July 2022

The inventory lists of private library collections may be counted among the most significant sources for the study of the history of books in the Middle Ages and the Renaissance. These inventories provide a true picture of the reading material used in a given historical period and reveal their owners’ spiritual preoccupations as well as those of their contemporaries. Many books listed in the inventories had disappeared from the collections over time, so the inventories remain the sole indicators helping us to reconstruct the spiritual life of the different social environments. The inventories deserve to be treated with exceptional reverence by the book historians.Example used by the author to show the type of information that might be learned from the inventory of a private library is the inventory of books that Nikola Pavlov de Gondola of Dubrovnik gave as a gift, in 1469, to the Benedictine monastery of St. Mary’s on the island of Lokrum near Dubrovnik. The inventory list comprises sixteen titles; among them are two milestones, Boccaccio’s The Decameron and Genealogies of the Gentile Gods. The two are the oldest specimens of these books ever to be discovered in Croatia. Using the standard methodology for book inventory analysis, developed by the so-called ‘middle generation’ of book historians, the author first establishes which book the inventory entry refers to and, then, he supplies information on the book. Finally, for the most important books, he sketches for the reader a wider context of the book ownership and use. The author also stresses the importance of the numerous private library inventories kept in the archives of Dubrovnik, Split, Zadar, etc. He argues that the publication and an in-depth analysis of the surviving inventories would supply valuable information not only on the books bought and read by their owners but also on the intellectual and cultural preoccupations of the social environments (towns) in which the owners lived.
Monografije o Hrvatima u Vojvodini od 1990. do 2008. - osnovne informacije
Authors: Žigmanov Tomislav , Bara Mario
Published: July 2022

Cilj je radnje prezentirati monografske publikacije o Hrvatima u Vojvodini u razdoblju od 1990. do kraja 2008. godine. Radnja donosi popis od 137 monografskih publikacija objavljenih u navedenom razdoblju, koje su tematski vezane uz društveni i kulturni život Hrvata u Vojvodini. Riječ je o djelima koja su heterogena po cijelom nizu značajki - od opsega, preko složenosti i obuhvata teme pa do znanstvene relevantnosti, no u jednu ih cjelinu okuplja istost teme.
Popis publikacija o vojvođanskim Hrvatima objavljen je slijedom koji prati podjelu prema Univerzalnoj decimalnoj klasifikaciji te abecedni popis autora, s tim da su anonimne i publikacije s više autora stavljene na početak niza. Usto, radnja sadrži i kratku analitičku obradu o mjestu objavljivanja djelâ i mjestu djelovanja autorâ, jeziku objave te području znanosti i tematici koja je u njima obrađena.
Doprinos je radnje sastavljanje vremenski definirane regionalne bibliografije koja po prvi put predstavlja sve poznate monografske publikacije o vojvođanskim Hrvatima u navedenom razdoblju.
Semiotički marketing Konstantina Ćirila Filozofa
Authors: Horvat Jasna , Tomašević Nives , Lendić Slaven
Published: July 2022

Cilj je rada, polazeći od teorijskog pristupa Davida G. Micka, Jamesa E. Burroughsa, Patricka Hetzela i Mary Y. Brannen (2004), istražiti jesu li teorije semiotičkog marketinga primjenjive u srednjovjekovnom kontekstu, tj. može li se reći da je Konstantin Ćiril Filozof u 9. stoljeću primijenio semiotički marketing pri kreiranju i promicanju glagoljskog pisma odnosno ideje kršćanstva.
Autori ukratko podsjećaju na razvoj semiotike i navode važnije teorije o semiotičkom marketingu, osvrću se na nekoliko teorija o postanku glagoljičkog pisma te potom primjenjuju navedene teorije na glagoljičke grafeme i pismovni sustav u cijelosti.
Životopis Konstantina Ćirila Filozofa nameće pretpostavku da se njegova misija odlikuje poštivanjem svih pravila marketinške komunikacije - izgradnjom glagoljičkog pisma Konstantin Ćiril Filozof promicao je ideju kršćanstva ugrađenu u vizualni identitet svakog pojedinačnog znaka (i svih znakova poredanih u azbučni niz) gotovo „slijedeći“ ili, bolje rečeno, anticipirajući naputke danas priznate teorije o pravilima učinkovite marketinške komunikacije. Autori postavljaju hipotezu da su glagoljička slova (grafemi) snažni proizvoljni znakovi čiju je proizvoljnost Konstantin Ćiril kodirao u smjeru ostvarenja ciljeva svoje misije.
Creutzfeldt–Jakob Disease with Stroke-Like Symptoms: Case report
Authors: Tosunoğlu Bünyamin , Dilek Sıddıka Sena , Emektar Ümmühanı , Yoldaş Tahir Kurtuluş
Published: July 2022

Creutzfeldt–Jakob disease (CJD) is a rare, progressive, and fatal prion disease. Often the first sign of CJD is rapidly progressive dementia, leading to memory loss, personality changes, and hallucinations. Myoclonus typically occurs in 90% of cases, but often may not be an initial symptom. Other frequently occurring psychiatric symptoms include depression, anxiety, paranoia, obsessive-compulsive symptoms, and psychosis. Speech disorder, loss of balance and coordination may also accompany. We present a case of CJD with sudden onset of right hemiparesis.
Rights and knowledge-based approach to aging and disability: an overview of issues and approaches
Authors: Krassioukova-Enns Olga , Ringaert Laurie
Published: July 2022

This analysis paper is part of a larger project led by the Canadian Centre on Disability Studies (CCDS) and funded by Human Resources and Social Development Canada (HRSDC), called “From Research and Knowledge to Better Practice: Building Strategies and Partnerships for Livable Communities That are Inclusive of Seniors with Disabilities” (2008-09). The central purpose of the larger project was to develop and test a model of livable and inclusive communities that includes the needs, preferences, and circumstances of seniors with disabilities. A participatory method was used to accomplish this goal by identifying the key principles and elements of what makes communities livable and inclusive for seniors with disabilities and to develop and test a Livable and Inclusive Community Evaluation Tool and process to measure the extent to which the community meets their needs. In addition, a Livable and Inclusive Community Planning Tool was developed and introduced to several pilot communities across Canada. This paper provides an overview of issues, needs and approaches to disability and aging and is the beginning of the subsequent series of papers. In this discussion the terms “seniors” and “older adults” are used interchangeably refl ecting the fl exible use of the terms in the North American context.
Positive experiencing of loneliness as a factor of personality
Authors: Mukhanova Iryna , Romanova Vira
Published: July 2022

The article focuses on the theoretical analysis of such a phenomenon as loneliness and the forms of experiencing it. The article provides an empirical research of loneliness, isolation, separation and personality’s emotional intellect as determinants of possible positive experience of loneliness. No association is established between evaluation of notions of the semantic feld of loneliness and the degree of emotional intellect maturity.
The effect of hippotherapy on trunk muscles emg, grasping force and functional mobility changes for person after coma
Authors: Aleknavičiūtė-Ablonksė Vaida , Savenkovienė Agnė , Mockevičienė Daiva , Miliūnienė Lina
Published: July 2022

The present research has been based on the case study. The changes of balance in trunk muscles, body mobility were evaluated during the hippotherapy sessions. During hypotherapy activities such as touching various parts of the horse’s body (e.g. the neck, flank, back) or reaching for an object (e.g. ball or ring), which involves crossing the midline while maintaining appropriate balance and posture are performed. Positive results were set up in isometric grip strength accordingly in right and in left hands 47 and 2 % and functional mobility in 50%. We found out greater EMG of RA, EO, LT and MF muscles in right vs left side during walking, and RA, LT during riding. We presume that increased grasping muscle strength is related with the increased trunk muscle strength and increased ability to maintain upright position
Teachers’ and parents’ attitude to relevance of sexuality education of adolescents with mild intellectual disabilities
Authors: Povilaitienė Neringa , Radzevičienė Liuda
Published: July 2022

The article deals with teachers’ and parents’ attitudes towards sexuality education of adolescents with mild intellectual disabilities. It is indicated that teachers treat sexuality education as a relevant problem of education of adolescents with mild intellectual disabilities due to pupils and parents’ insufficient knowledge about sexuality education. Informants are particularly concerned about pupils’ active sex life, which often results in early pregnancy, sexually transmitted diseases, etc. Problems are determined by pupils’ emotional and behavioural problems, lack of social skills, and deepened by the negative impact of the family and environment. During the research, the prevalence of different attitudes of participants of the educational process (parents and teachers) towards sexuality education of adolescents with mild intellectual disabilities in social and educational environment was observed. Teachers state that sexuality education is a relevant problem due to pupils’ early sexual interactions, lack of social skills, emotional and behavioural problems and demonstration of destructive sexual behaviour.
Long-term reliability of the Finnish behavioral and emotional rating scale
Authors: Lambert Matthew C. , Savolainen Hannu , Sointu Erkko T. , Lappalainen Kristiina , Epstein Michael H.
Published: July 2022

In previous research, the Finnish version of the Behavioral and Emotional Rating Scale-2 has demonstrated adequate internal consistency, factor structure and convergent validity. The purpose of the present study was to examine the long-term test-retest reliability of the Finnish BERS-2. Youth, parent and teacher BERS-2 ratings were collected once a year for three years in order to assess the stability of scores. All of the correlations were significant and moderate to very large in magnitude. Study limitations, future research and implications were discussed.
Photoperiod-induced alterations in biomarkers of oxidative stress in rats of different ages and individual physiological reactivity
Authors:   Institute of Biology and Earth Sciences, Pomeranian University in Słupsk, 22b Arciszewskiego str., Słupsk,76-200, Poland, Kurhaluk N. , Tkachenko H. ,   Institute of Biology and Earth Sciences, Pomeranian University in Słupsk, 22b Arciszewskiego str., Słupsk,76-200, Poland, Partyka T. ,   Institute of Agriculture of the Carpathian Region NAAS, 5 Hrushevskoho str., Obroshyne, Lviv district, 81115, Ukraine
Published: July 2022

This study was undertaken to investigate the photoperiod- and age-related variability between the activity of oxidative stress biomarkers in rats with different physiological reactivity estimated by different resistance to hypoxia. The study was carried out on 96 male Wistar rats divided into 16 groups based on resistance to hypoxia (LR, low resistance, HR, high resistance) and age, i.e. 6 and 21 months. The studies were conducted at four photoperiod points: winter (January), spring (March), summer (July), and autumn (October). Lower levels of oxidative stress biomarkers (P<0.05) were observed in the younger rats when compared to older rats, as well as in HR rats compared to LR rats. The levels of lipid peroxidation end product, 2-thiobarbituric acid reactive substances (TBARS) as the major indicator of oxidative stress, were found to increase with age, and summer resulted in further elevation compared to other seasons. Also, oxidative stress biomarkers were lower (P<0.05) in winter than in other seasons, especially in the HR rats. TAC level in the hepatic tissue of the 6 months aged rats was significantly higher (P<0.05) elevated when compared to older rats. A similar higher TAC level was in the hepatic tissue of HR rats compared to the LR rats. The adult rats with HR maintained TAC with minimal fluctuations throughout the year. It should be noted that the difference in TAC was higher for the groups of the adult animals with HR in winter, spring, and summer, which may indicate effective mechanisms preventing the formation of reactive oxygen species and systems of elimination thereof.
Selection criteria for highly productive breeding boars and sows by fattening and meat qualities of their offspring using some evaluation indexes
Authors:   State Institution Institute of Grain Crops NAAS, 14 Volodymyr Vernadskyi str., Dnipro, 49027, Ukraine, Khalak V. I. , Zhukorsky O. M. ,   National Academy of Agrarian Sciences of Ukraine, 9 Mykhailo Omelyanovych-Pavlenko str., Kyiv, 901010, Ukraine, Tserenyuk O. M. ,   Institute of Pig Breeding and Agrarian Sciences NAAS, 1 Shvedska Mohyla str., Poltava, 36013, Ukraine
Published: July 2022

The aim of the work is to study the fattening and meat qualities of young white pigs and to determine the criteria for selection of high-yielding breeding boars and sows using some evaluation indices. It was found that young pigs of large white breed of the controlled population at the age of 100 kg exceed the minimum requirements of the elite class by 6.13%, the thickness of the fat at the level of 6–7 thoracic vertebrae — 32.25% and the length of chilled carcass — 3.92%. Significant difference between animals of different intrabreed differentiation according to the Tyler index (groups I and III) was established by the average daily gain of live weight during the control period of fattening (91.7 g), age of 100 kg live weight (7.3 days), fat thickness at the level of 6–7 thoracic vertebrae (3.4 mm), length of chilled carcass (1.7 cm), length of bacon half of chilled carcass (2.7 cm). Taking into account the intrabreed differentiation according to the Sazer-Fredin index, it was found that young pigs of group II outperformed peers of I on average daily live weight gain for the period of control fattening by 4.03%, age of 100 kg — 3.67% and length of chilled carcass — 0.2%. The pairwise correlation coefficient between fattening and meat qualities of young pigs and evaluation indices ranges from –0.710 (tr=10.24) to +0.844 (tr=20.98). The maximum increase in additional products was obtained from young pigs of the first experimental group according to the Tyler index (+5.03%) and the second experimental group according to the Sazer-Fredin index (+1.12%). The cost of additional products obtained from young pigs of these groups, provided that the selling price per 1 kg of live weight of young pigs at the time of the study was 47.5 UAH. is +247.51 and +55.42 UAH/animal respectively. Thus, the criteria for selecting highly productive breeding boars and sows for fattening and meat qualities are the limits of the Tyler index 214.89–242.85, the Sazer-Fredin index — –3.018 — –0.102 points.