bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between serum irisin concentrations and sarcopenia in patients with liver cirrhosis: a cross-sectional study
Authors: Zhao Mingyuan , Zhou Xiaoshuang , Yuan Chengying , Li Rongshan , Ma Yuehong , Tang Xiaoxian
Published: September 2020

Sarcopenia is an independent predictor of mortality in patients with liver cirrhosis. However, evidence has emerged that skeletal muscles mediate their protective effect against sarcopenia by secreting myokines. Therefore, we investigated whether irisin was associated with sarcopenia in patients with liver cirrhosis. This was an observational cross-sectional study of data collected from 187 cirrhotic patients. Sarcopenia was defined by computed tomography (CT) scans using specific cutoffs of the 3rd lumbar vertebra skeletal muscle index (L3 SMI). Morning irisin levels were obtained in all patients. Of the 187 patients, sarcopenia was noted in 73 (39%). Irisin concentrations were lower in sarcopenic patients (32.40 pg/ml [interquartile range (IQR): 18.70, 121.26], p < 0.001) than in nonsarcopenic patients. There was a weak correlation between L3 SMI and irisin levels (r = 0.516, p < 0.001). Multivariable regression analysis including L3 SMI, body mass index (BMI), very-low-density lipoprotein (VLDL)-cholesterol, aspartate aminotransferase (AST), adiponectin, and irisin levels showed that L3 SMI (odds ratio [OR] = 0.915, p = 0.023), adiponectin levels (OR = 1.074, p = 0.014), irisin levels (OR = 0.993, p < 0.001) and BMI (OR = 0.456, p = 0.004) were independently associated with sarcopenia. Irisin levels are associated with sarcopenia in patients with liver cirrhosis. This paper addresses a gap in the literature and facilitates the future transition into clinical treatment.
Efficacy and safety of a single switch from etanercept originator to etanercept biosimilar in a cohort of inflammatory arthritis
Authors: Ditto Maria Chiara , Parisi Simone , Priora Marta , Sanna Silvia , Peroni Clara Lisa , Laganà Angela , D’Avolio Antonio , Fusaro Enrico
Published: September 2020

AntiTNF-α biosimilars are broadly available for the treatment of inflammatory arthritis. There are a lot of data concerning the maintenance of clinical efficacy after switching from originators to biosimilars; therefore, such a transition is increasingly encouraged both in the US and Europe. However, there are reports about flares and adverse events (AE) as a non-medical switch remains controversial due to ethical and clinical implications (efficacy, safety, tolerability). The aim of our work was to evaluate the disease activity trend after switching from etanercept originator (oETA-Enbrel) to its biosimilar (bETA-SP4/Benepali) in a cohort of patients in Turin, Piedmont, Italy. In this area, the switch to biosimilars is stalwartly encouraged. We switched 87 patients who were in a clinical state of stability from oETA to bETA: 48 patients were affected by Rheumatoid Arthritis (RA),26 by Psoriatic Arthritis (PsA) and 13 by Ankylosing Spondylitis (AS).We evaluated VAS-pain, Global-Health, CRP, number of swollen and tender joints, Disease Activity Score on 28 joints (DAS28) for RA, Disease Activity in Psoriatic Arthritis (DAPSA) for PsA, Health Assessment Questionnaire (HAQ) and Health Assessment Questionnaire for the spondyloarthropathies (HAQ-S),Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for AS patients. 11/85 patients (12.6%) stopped treatment after switching to biosimilar etanercept. No difference was found between oETA and bETA in terms of efficacy. However, some arthritis flare and AE were reported. Our data regarding maintenance of efficacy and percentage of discontinuation were in line with the existing literature.
A multilevel analysis identifies the different relationships between amino acids and the competence of oocytes matured individually or in groups
Authors: Kowsar Rasoul , Mansouri Alireza , Sadeghi Nima , Abadi Mohammad Heidaran Ali , Ghoreishi Seyed Mehdi , Sadeghi Khaled , Miyamoto Akio
Published: September 2020

High-protein diets contribute to an increase in urea follicular concentrations associated with decreased fertility. Urea has been shown to interfere with the epidermal growth factor (EGF)/EGFR system, which has been shown to have a beneficial effect during in vitro maturation (IVM) of oocytes. Of note, the number of cumulus-oocyte complexes (COCs) in the maturation medium can change the maturation and the developmental competence of COCs. Therefore, it was hypothesized that, the presence of urea and EGF may have a differential effect on the depletion/appearance of AAs and competence of COCs matured individually (I-IVM system) or in groups (G-IVM system). In the G-IVM system, COCs increased consumption (depletion) of AAs compared with other groups in the presence of high-level urea (40 mg/dl) + EGF (10 ng/ml). In the I-IVM system, the non-cleaved COCs depleted more AAs than the cleaved COCs, in particular in the presence of urea. The combination of urea and EGF increased the depletion of AAs in the G-IVM system. However, the EGF abrogated the urea-induced depletion of AAs by the I-IVM COCs. The use of N-acetyl-l-cysteine as an EGFR inhibitor canceled urea-induced depletion of AAs. This shows the inhibiting effect of urea over the EGF/EGFR system. In the presence of urea + EGF, COCs had a lower degree of developmental competence than control in both I- and G-IVM systems. Arginine had the best predictive power to identify highly competent COCs in the G-IVM system, while glutamine was the best predictor of the cleavage in the I-IVM system. In conclusion, this multi-level study shows that COCs matured individually or in groups may have different association with AAs metabolism. These findings provide new insights into the relationships between AA metabolism and the subsequent developmental competence of COCs.
Single molecule studies reveal that p53 tetramers dynamically bind response elements containing one or two half sites
Authors: Ly Elina , Kugel Jennifer F. , Goodrich James A.
Published: September 2020

The tumor suppressor protein p53 is critical for cell fate decisions, including apoptosis, senescence, and cell cycle arrest. p53 is a tetrameric transcription factor that binds DNA response elements to regulate transcription of target genes. p53 response elements consist of two decameric half-sites, and data suggest one p53 dimer in the tetramer binds to each half-site. Despite a broad literature describing p53 binding DNA, unanswered questions remain, due partly to the need for more quantitative and structural studies with full length protein. Here we describe a single molecule fluorescence system to visualize full length p53 tetramers binding DNA in real time. The data revealed a dynamic interaction in which tetrameric p53/DNA complexes assembled and disassembled without a dimer/DNA intermediate. On a wild type DNA containing two half sites, p53/DNA complexes existed in two kinetically distinct populations. p53 tetramers bound response elements containing only one half site to form a single population of complexes with reduced kinetic stability. Altering the spacing and helical phasing between two half sites affected both the population distribution of p53/DNA complexes and their kinetic stability. Our real time single molecule measurements of full length p53 tetramers binding DNA reveal the parameters that define the stability of p53/DNA complexes, and provide insight into the pathways by which those complexes assemble.
Study of the hydrogen physisorption on adsorbents based on activated carbon by means of statistical physics formalism: modeling analysis and thermodynamics investigation
Authors: Yahia Manel Ben , Wjihi Sarra
Published: September 2020

An advanced statistical physics model has been applied to study the hydrogen adsorption isotherm on two modified types of activated carbon, namely granular coal activated carbon (AC (GC)) and coconut shell activated carbon (AC (CS)). This model is established with the statistical physics approach. It is a more general model including various parameters having a defined physico-chemical sense which were discussed at different temperatures. Hence new physic-chemical interpretations of the adsorption process of hydrogen are provided. The analysis of the hydrogen uptake capacities at saturation showed that the AC (GC) adsorbent displayed a high adsorption capacity (3.21 mg/g). This due to the contribution of the number of hydrogen molecules per site (1.27) associated with the receptor sites density (0.74 mg/g) and the number of formed layers (3.42). The modeling results suggested that the hydrogen adsorption occurred by non-parallel positions on the two tested adsorbents thus evincing that the adsorption cannot be other than a multi-molecular process. The calculated adsorption energies globally varied from 7.01 to 12.92 kJ/mol, confirming the physical nature of the adsorption process for both studied systems. The thermodynamic functions, namely internal energy, enthalpy and entropy were estimated to better analyze the hydrogen sorption process. In summary, the statistical physics analysis provided reliable concrete physico-chemical interpretations of hydrogen adsorption process on carbon-based adsorbents with various microstructures to develop a storage compounds with a suitable framework for a hydrogen storage structure.
Breakdown of chiral recognition of amino acids in reduced dimensions
Authors: Jeong Yongchan , Kim Hyo Won , Ku JiYeon , Seo Jungpil
Published: September 2020

The homochirality of amino acids in living organisms is one of the great mysteries in the phenomena of life. To understand the chiral recognition of amino acids, we have used scanning tunnelling microscopy to investigate the self-assembly of molecules of the amino acid tryptophan (Trp) on Au(111). Earlier experiments showed only homochiral configurations in the self-assembly of amino acids, despite using a mixture of the two opposite enantiomers. In our study, we demonstrate that heterochiral configurations can be favored energetically when l- and d-Trp molecules are mixed to form self-assembly on the Au surface. Using density functional theory calculations, we show that the indole side chain strongly interacts with the Au surface, which reduces the system effectively to two-dimension, with chiral recognition disabled. Our study provides important insight into the recognition of the chirality of amino acid molecules in life.
Cell-free biogenesis of bacterial division proto-rings that can constrict liposomes
Authors: Godino Elisa , López Jonás Noguera , Zarguit Ilias , Doerr Anne , Jimenez Mercedes , Rivas Germán , Danelon Christophe
Published: September 2020

A major challenge towards the realization of an autonomous synthetic cell resides in the encoding of a division machinery in a genetic programme. In the bacterial cell cycle, the assembly of cytoskeletal proteins into a ring defines the division site. At the onset of the formation of the Escherichia coli divisome, a proto-ring consisting of FtsZ and its membrane-recruiting proteins takes place. Here, we show that FtsA-FtsZ ring-like structures driven by cell-free gene expression can be reconstituted on planar membranes and inside liposome compartments. Such cytoskeletal structures are found to constrict the liposome, generating elongated membrane necks and budding vesicles. Additional expression of the FtsZ cross-linker protein ZapA yields more rigid FtsZ bundles that attach to the membrane but fail to produce budding spots or necks in liposomes. These results demonstrate that gene-directed protein synthesis and assembly of membrane-constricting FtsZ-rings can be combined in a liposome-based artificial cell.
Selective and simultaneous sensing of ascorbic acid, dopamine and uric acid based on nitrogen-doped mesoporous carbon
Authors: Zhou Xiaoping , He Yi , Tao Shihan , Wang Jiangyi , Li Fan , Guo Qiaohui
Published: September 2020

A nitrogen-doped mesoporous carbon was synthesized by pyrolyzing a mixture of melamine and carbon black at a low-temperature (600 °C) for the selective and sensitive sensing of AA, DA and UA.
Thermal defect engineering of precious group metal–organic frameworks: impact on the catalytic cyclopropanation reaction
Authors: Heinz Werner R. , Junk Raphael , Agirrezabal-Telleria Iker , Bueken Bart , Bunzen Hana , Gölz Thorsten , Cokoja Mirza , De Vos Dirk , Fischer Roland A.
Published: September 2020

This work highlights the catalytic cyclopropanation and its characteristics as a novel analytical tool to investigate complex MOF structures.
Robust, remeltable and remarkably simple to prepare biomass–sulfur composites
Authors: Lauer Moira K. , Karunarathna Menisha S. , Tennyson Andrew G. , Smith Rhett C.
Published: September 2020

Lignocellulosic biomass holds a tremendous opportunity for transformation into carbon-negative materials, yet the expense of separating biomass into its cellulose and lignin components remains a primary economic barrier to biomass utilization.
High-performance 5.1 nm in-plane Janus WSeTe Schottky barrier field effect transistors
Authors: Fan Zhi-Qiang , Zhang Zhen-Hua , Yang Shen-Yuan
Published: September 2020

Transfer characteristics and benchmarks of 5.1 nm double-gated SBFETs consisting of IP heterojunctions of the metallic-phase MTe2 (M = Ti, Zr, Hf, Cr, Mo, W) and semiconducting-phase WSe2, WTe2 and Janus WSeTe are studied in this paper.
An ATP responsive fluorescent supramolecular assembly based on a polyelectrolyte and an AIE active tetraphenylethylene derivative
Authors: Singh Vidya R. , Malegaonkar Jotiram N. , Bhosale Sidhanath V. , Singh Prabhat K.
Published: September 2020

A supramolecular assembly is constructed using an anionic AIE active probe and a cationic polyelectrolyte to sense ATP fluorimetrically in solution.
Radio-frequency and optically transparent radome de-icing materials: fluorine-doped tin oxide
Authors: Kim Young-Ryeul , Park Jin-Woo , Park Sung-Hwan , Lee Seung-Jun
Published: September 2020

Ice-elimination systems are very common in radio-frequency (RF) structures like radomes.
Green preparation of anti-inflammation an injectable 3D porous hydrogel for speeding up deep second-degree scald wound healing
Authors: Xu Xiao , Che Lin , Xu Lin , Huang Doudou , Wu Jiashen , Du Zebang , Lin Yuchun , Hu Xiaoqian , Zhao Qingliang , Lin Zhongning , Xu Ling
Published: September 2020

The injectable 3D porous hydrogel with a double crosslinked network could be applied as a multifunctional injectable scald wound dressing material for anti-inflammation, necrotic tissue-removal, and wound closure.
Microwave assisted synthesis of five membered nitrogen heterocycles
Authors: Meera Gopinadh , Rohit K. R. , Saranya Salim , Anilkumar Gopinathan
Published: September 2020

Microwave assisted synthesis of N-heterocycles with short reaction time, high yields and high product purities along with a decrease in the rate of by-product formation.
Investigation of some benzoquinazoline and quinazoline derivatives as novel inhibitors of HCV-NS3/4A protease: biological, molecular docking and QSAR studies
Authors: Abuelizz Hatem A. , Marzouk Mohamed , Bakheit Ahmed H. , Al-Salahi Rashad
Published: September 2020

HCV NS3/A4 protease inhibitors are one of the best therapeutic targets for the identification of novel candidate drugs. A series of benzo[g]quinazolines and their quinazoline analogues were evaluated for their HCV-NS3/4A inhibitory activities.
Iron oxide nanoparticle-induced hematopoietic and immunological response in rats
Authors: Gaharwar Usha Singh , Kumar Sumit , Rajamani Paulraj
Published: September 2020

The application and use of iron oxide nanoparticless (IONPs) in the biomedical field are steadily increasing, although it remains uncertain whether IONPs are safe or should be used with caution.
A sandwich-type bacteriophage-based amperometric biosensor for the detection of Shiga toxin-producing Escherichia coli serogroups in complex matrices
Authors: Quintela Irwin A. , Wu Vivian C. H.
Published: September 2020

Sandwich-type bacteriophage-based amperometric biosensor for the detection of Shiga toxin-producing Escherichia coli serogroups in complex matrices.
AuNPs@PMo12nanozyme: highly oxidase mimetic activity for sensitive and specific colorimetric detection of acetaminophen
Authors: Rohani Bastami Tahereh , Dabirifar Zeynab
Published: September 2020

The design of a highly specific and sensitive approach for the quantitative and qualitative determination of acetaminophen (AP) is crucial from a human health point of view.
Polyoxotungstate ([PW11O39]7−) immobilized on mesoporous polymer for selective liquid-phase oxidation of alcohols using H2O2
Authors: Churipard Sathyapal R. , Kanakikodi Kempanna S. , Choudhuri Jyoti Roy , Maradur Sanjeev P.
Published: September 2020

Selective oxidation of alcohols using polyoxotungstate immobilized mesoporous polymer.
A photocleavable peptide-tagged mass probe for chemical mapping of epidermal growth factor receptor 2 (HER2) in human cancer cells
Authors: Liu Liang , Kuang Yuqiong , Wang Zhongcheng , Chen Yun
Published: September 2020

An integrated approach based on a photocleavable peptide tagged mass probe provides chemical mapping including quantitative and visual information of HER2.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Authors: Nguyen Duc Duy , Gao Kaifu , Chen Jiahui , Wang Rui , Wei Guo-Wei
Published: September 2020

By integrating algebraic topology and deep learning, we provide a reliable ranking of binding affinities, binding site analysis, and fragment decomposition for 137 SARS-CoV-2 main protease inhibitors.
Aperiodic metal–organic frameworks
Authors: Oppenheim Julius J. , Skorupskii Grigorii , Dincă Mircea
Published: September 2020

This perspective discusses progress and future directions in metal–organic frameworks with aperiodic structures. Reported quasicrystalline and incommensurate materials are presented, and pathways towards designing new such materials are provided.
PLGA nanoparticle-reinforced supramolecular peptide hydrogels for local delivery of multiple drugs with enhanced synergism
Authors: Wu Can , Wang Chunlu , Sun Lu , Xu Keming , Zhong Wenying
Published: September 2020

We reported the fabrication of PLGA nanoparticle-reinforced supramolecular peptide hydrogels for local delivery of multiple drugs with enhanced synergism.
Dynamics of progressive pore clogging by colloidal aggregates
Authors: Delouche N. , Schofield A. B. , Tabuteau H.
Published: September 2020

Difference between the capture dynamics of spherical particles and aggregates within a constriction.
Water dynamics and self-assembly of single-chain nanoparticles in concentrated solutions
Authors: Robles-Hernández Beatriz , González Edurne , Pomposo José A. , Colmenero Juan , Alegría Ángel
Published: September 2020

Dielectric studies on water dynamics in aqueous solutions of amphiphilic random copolymers confirm the self-assembly into globular like core–shell single-chain nano-particles (SCNPs) at concentrations well above the overlap concentration.
Self-healable transparent polymer/salt hybrid adhesiveviaa ternary bonding effect
Authors: Zhang Yuanyuan , Zhang Ke , Li Xuanhua , Li Tong , Ye Qian , Tan Li-Li , Wei Bingqing
Published: September 2020

A transparent self-healable hybrid adhesive with multiple functions based on a novel co-existing ternary bridging bond self-healing mechanism.
Elucidating the impact of molecular weight on morphology, charge transport, photophysics and performance of all-polymer solar cells
Authors: Tran Duyen K. , Robitaille Amélie , Hai I. Jo , Ding Xiaomei , Kuzuhara Daiki , Koganezawa Tomoyuki , Chiu Yu-Cheng , Leclerc Mario , Jenekhe Samson A.
Published: September 2020

This work provides a unified understanding on how polymer molecular weight influences the blend photophysics, blend morphology, charge transport, and photovoltaic properties of all-polymer solar cells.
Metal-based electrocatalytic conversion of CO2 to formic acid/formate
Authors: Ding Peng , Zhao Haitao , Li Tingshuai , Luo Yongsong , Fan Guangyin , Chen Guang , Gao Shuyan , Shi Xifeng , Lu Siyu , Sun Xuping
Published: September 2020

This review summarizes recent progress in the development of metal-based electrocatalysts for the reduction of CO2 to formic acid/formate. The current challenges and the future research directions of metal-based materials are also proposed.
Enhancement in hard magnetic properties of nanocrystalline (Ce,Y)–Fe–Si–B alloys due to microstructure evolution caused by chemical heterogeneity
Authors: Zhang J. S. , Liao X. F. , Xu K. , He J. Y. , Fan W. B. , Yu H. Y. , Zhong X. C. , Liu Z. W.
Published: September 2020

The nano-level chemical heterogeneity due to the Y segregation in RE2Fe14B phase and Ce segregation in REFe2 phase enhance the hard magnetic properties of (Y,Ce)-Fe-B alloys, which offers a potential approach to improve the cost performance of free-RE magnets.
Atomic scale study of the oxygen annealing effect on piezoelectricity enhancement of (K,Na)NbO3 nanorods
Authors: Li Luying , Hu Xiaokang , Jin Lei , He Yahua , Jia Shuangfeng , Sheng Huaping , Cheng Yongfa , Li Li , Wang Zhao , Gu Haoshuang , Zhu Yinlian , Wang Jianbo , Gao Yihua
Published: September 2020

An atomic-scale study of the oxygen annealing effect on the piezoelectricity enhancement of (K,Na)NbO3 nanorods via structure, strain and dipolar displacement vector analyses.
Recent progress in integrated functional electrochromic energy storage devices
Authors: Wang Hao , Yao Chang-Jiang , Nie Hai-Jing , Yang Li , Mei Shilin , Zhang Qichun
Published: September 2020

The recent development of organic, inorganic and hybrid materials for applications in electrochromic energy storage is summarized in terms of working principles, device structures and the possibility of combination.
The Relationship Between Speech Characteristics and Motor Subtypes of Parkinson's Disease
Authors: Brown Katherine A. , Spencer Kristie A.
Published: September 2020

Purpose

The aim of this study was to examine whether acoustic dysarthria characteristics align with overall motor profile in individuals with Parkinson's disease (PD). Potential speech differences between tremor-dominant and non–tremor-dominant subtypes are theoretically motivated but empirically inconclusive.

Method

Twenty-seven individuals with dysarthria from PD provided a contextual speech sample. Participants were grouped into non–tremor-dominant (
n
= 12) and tremor-dominant (
n
= 15) motor subtypes according to the Unified Parkinson Disease Rating Scale. Dependent speech variables included fundamental frequency range, average pause duration, cepstral peak prominence, stuttering dysfluencies, and maze dysfluencies.

Results

There were no significant differences between the speech of the tremor-dominant and non–tremor-dominant groups. High within-group variability existed across parameters and motor subtypes.

Conclusion

Speech characteristics across the areas of phonation, prosody, and fluency did not differ appreciably between PD motor subtypes.
VIBES: Visual Binary Exoplanet survey with SPHERE
Authors: Hagelberg J. , Engler N. , Fontanive C. , Daemgen S. , Quanz S. P. , Kühn J. , Reggiani M. , Meyer M. , Jayawardhana R. , Kostov V.
Published: September 2020

Context. Recent surveys indicate that planets in binary systems are more abundant than previously thought, which is in agreement with theoretical work on disc dynamics and planet formation in binaries. So far, most observational surveys, however, have focused on short-period planets in binaries, thus little is known about the occurrence rates of planets on longer periods (≥10 au).

Aims. In order to measure the abundance and physical characteristics of wide-orbit giant exoplanets in binary systems, we have designed the “VIsual Binary Exoplanet survey with Sphere” (VIBES) to search for planets in visual binaries. It uses the SPHERE instrument at VLT to search for planets in 23 visual binary and four visual triple systems with ages of <145 Myr and distances of <150 pc.

Methods. We used the IRDIS dual-band imager on SPHERE to acquire high-contrast images of the sample targets. For each binary, the two components were observed at the same time with a coronagraph masking only the primary star. For the triple star, the tight components were treated as a single star for data reduction. This enabled us to effectively search for companions around 50 individual stars in binaries and four binaries in triples.

Results. We derived upper limits of <13.7% for the frequency of sub-stellar companions around primaries in visual binaries, <26.5% for the fraction of sub-stellar companions around secondaries in visual binaries, and an occurrence rate of <9.0% for giant planets and brown dwarfs around either component of visual binaries. We have combined our observations with literature measurements to astrometrically confirm, for the first time, that 20 binaries and two triple systems, which were previously known, are indeed physically bound. Finally, we discovered a third component of the binary HD 121336.

Conclusions. The upper limits we derived are compatible with planet formation through the core accretion and the gravitational instability processes in binaries. These limits are also in line with limits found for single star and circumbinary planet search surveys.
Light-time effect detected in fourteen eclipsing binaries
Authors: Zasche P. , Uhlař R. , Svoboda P. , Cagaš P. , Mašek M.
Published: September 2020

The available minima timings of 14 selected eclipsing binaries (V1297 Cas, HD 24105, KU Aur, GU CMa, GH Mon, AZ Vel, DI Lyn, DK Her, GQ Dra, V624 Her, V1134 Her, KIC 6187893, V1928 Aql, V2486 Cyg) were collected and analyzed. Using the automatic telescopes, surveys, and satellite data, we derived more than 2500 times of eclipses, accompanied with our own ground-based observations. These data were used to detect the period variations in these multiple systems. The eclipse timing variations were described using the third-body hypothesis and the light-time effect. Their respective periods were derived as 2.5, 16.2, 27, 20, 64, 5.6, 22, 115, 27, 42, 6.9, 11.2, 4.1, and 8.4 years for these systems, respectively. The predicted minimal mass of the third body was calculated for each of the systems, and we discuss here their prospective detectability. The light curves of HD 24105, GH Mon, DK Her, V1134 Her, KIC 6187893, V1928 Aql, and V2486 Cyg were analyzed using the PHOEBE program, resulting in physical parameters of the components. Significant fractions of the third light were detected during the light-curve analysis, supporting our hypothesis of the triple-star nature of all these systems. The majority of these systems (nine out of 14) were already known as visual doubles. Our study shifts them to possible quadruples, what makes them even more interesting.
Special aspects of explosive loosening with minimal rock displacement
Authors: Shevkun Evgeny , Leshchinsky Aleksander , Plotnikov Andrey
Published: September 2020

The dynamics of the development of an industrial mass explosion at deceleration intervals of 150x200 ms on a frame-by-frame video recording on a consumer video camera with a shooting frequency of 25 frames per second is studied. Possibilities of visual assessment of the explosion site of individual borehole charges are evaluated. The main difficulties in recording processing are caused by the difference in the intervals between frames (40 ms) and decelerations between charges (50 ms). A significant deviation of the actual deceleration intervals from the nominal value was revealed, which significantly changes the actual picture of the development of a mass explosion, including an increase in the actual development time of a mass explosion against the calculated one. The passage through the zones of the location of individual borehole charges up to 40 stress waves was established. Such multiple impacts of stress waves are expressed in a decrease in the magnitude of the interval velocities of dust and gas emissions as the number of impacts of stress waves increases. Due to the multiple effects of stress waves in the extension stage, the fracturing of the rock mass increases. This is expressed in a decrease in the dynamics, and then in the termination of the outburst of bottom hole material as the disturbance of rocks in the prefracture zone increases. There is no breakdown of rocks; the “ore-rock” contacts have retained their original position, which makes it possible to reduce the dilution of ore to a minimum.
A novel acoustic emission parameter for predicting rock failure during Brazilian test based on cepstrum analysis
Authors: Wang Honglei , Li Zhenlei , He Xueqiu , Song Dazhao , Guo Haifeng
Published: September 2020

Acoustic emission (AE) is widely used in the monitoring of coal and rock stability and early warning of dynamic disasters in mines. In this work, the Brazilian split test was carried out on limestone samples along with collecting full waveform AE signal during the entire loading process. The linear cepstrum coefficient (LCC) was used as the characteristic parameter of AE to analyze the correlation between the LCC of AE and the load of the samples. The results show that the LCC is an effective AE characteristic parameter. The first to fourth parameters of the LCC calculated using 1 s AE waveform meet the linear change relationship with the load of the samples. The correlation coefficients are 0.969, 0.943, 0.925, 0.833, respectively. The LCC of AE proposed in this work can be used as a characteristic parameter for predicting the tensile failure of rocks, which is helpful to improve the application effect of AE in the monitoring of coal and rock dynamic disasters and the stability of high and steep slopes.
Investigation of the deformations character of the Rudny fault shores during the development of the Yuzhnoye Deposit, Primorsky Krai
Authors: Fedotova Iuliia
Published: September 2020

In seismically active areas, ore-controlling faults play an important role in the geodynamics of underground mining of rockbursthazardous vein deposits. Moreover, the nature of deformations of the shores of such faults depends on a combination of various factors. The article presents the results of research conducted on the basis of visual observations of the author in the workings and the analysis of the database of measurements of distances between pairs of reference points of the observation station No. 1, installed on the “Rudny” fault of the “Yuznoye” section of the “2 Sovetsky” mine for the period 2012-2019. The analysis made it possible to identify the nature of deformations, establish their cyclical nature and rhythms of changing types of vibrations.
Technology of extraction and primary processing of low-grade and off-balance ores
Authors: Cheban Anton
Published: September 2020

In connection with the decline in the quality of reserves of many types of mineral wealth, there is a need to develop mining techniques and technologies that allow for effective development of deposits having increasingly hard mining conditions. In the ores of non-ferrous, rare and noble metals, the concentration of ore minerals in small classes of loosened ore mass is often observed. The paper analyzes the nature of the distribution of gold, tungsten, lead and some other useful components in the original ores, and presents methods for the treatment and primary processing of the ore mass with the separation of enriched classes. An engineering and technological solution has been proposed that provides an increase in production efficiency in opencast mining of deposits, the ores of which, after disintegration, are characterized by the enrichment of small classes, due to the separation of substandard ore siftings in the mine face directly during mining operations, their subsequent sorting and processing, as well as increased productivity and extended functionality of mining equipment. The use of the mining complex when excavating the rock mass will provide a reduction in the cost price, which will allow the complex-structured areas of the deposits to be involved in the development, composed of low-grade and off-balance ores.
Assessment and control of geodynamical risks under the conditions of a rock-bump hazardous complex deposit
Authors: Rasskazov Igor , Sidlyar Alexander , Tereshkin Andrei , Golosov Andrei
Published: September 2020

Research has been carried out to study the peculiarities of rockbump hazards and induced seismic manifestations at the Nikolaevskoe deposit, and their close correlation with the tectonic structure of the rock massif has been established. In order to strengthen control over the rock-bump hazard in the TN-3 high-angle fault, in 2019 the observation network was expanded and continuous seismoacoustic monitoring of the rock mass at the deep levels of Nikolaevskoe deposit was organized. Monitoring data is verified by local geoacoustic method using the portable device “Prognoz L”. The results of the monitoring revealed major acoustically active zone with the main amount of seismic and acoustic events recorded during the last 5 years and occurring dynamic rock pressure manifestations. Nikolaevskoe deposit was the site of execution of the industrial experiment on regional discharge of a potentially rock-bump hazardous section of a shock blasting massif.
Maintaining thermal stability of a fill slope in cryolithozone
Authors: Romanova Elena , Khokholov Yuri
Published: September 2020

The paper describes a solution to the problem of maintain the stability of a fill slope through artificial freezing with seasonal cooling units in cryolithozone. A three-dimensional mathematical model was developed to calculate the heat flow in a fill slope reinfirced with a gabion wall, taking into account the liquid-liquid phase transition and the use of seasonally operating cooling units. The developed mathematical model, based on the finite difference method and implemented as an application for Microsoft Windows, allows making a long-term forecast of a temperature field in a fill slope, depending on various design and technological parameters (location, dimensions and an operating mode of thermal stabilizers) and its effect on the stability of the slope. The results of studying the contribution of thermal stabilization to a reduced destructive temperature effect of the environment on the slope are given. The study showed the effectiveness of using seasonal cooling units for increasing the stability of fill slopes by freezing. In subsequent years after the thermal stabilization, the frozen zone in the fill slope is preserved, with the slope gradually switching to the natural seasonal temperature regime. The paper is recommended for researchers and designing engineers dealing with applied issues of mining thermal physics.
Analysis of blasting seismic impact on underground mining workings under the conditions of the Magnezitovaya mine
Authors: Kutuev Vyacheslav , Menshikov Pavel , Zharikov Sergey
Published: September 2020

Seismic impact of technological explosions on underground mining workings of the Magnezitovaya mine was assessed. Seismic stability of rocks of the Magnezitovaya mine was determined and safe distances from technological explosions have been calculated by the admissible seismic effect for rocks. URAN and Minimate Plus seismic recorders with three-component seismic receivers were used to establish the dynamic impact on the mine workings. Based on comparison of calculated values and experimental measurements, the recommendations are given for explosive mass limitation at a slowing-down stage at a level of minimum dangerous values for technological explosions in underground mine. It is established that the blasting operations carried out at the Magnezitovaya mine of PAO Magnezit Combine with fan longhole stopping were performed with the seismic impact safety of underground technological explosion and will not lead to the loss of rock mass stability near the underground workings. Relevance of these studies is to ensure industrial safety of underground mining operations.
Development and bench tests of a programmable logic controller “Simens Logo” based control system of an electromagnetic hammer for destruction of boulders
Authors: Vassin Konstantin , Yedygenov Yerik , Aldiyarov Nakhypbek , Voronin Vladimir
Published: September 2020

The development a programmable logic controller (PLС) based control system of electromagnetic hammer for destruction of boulders is described in the article. During bench tests of the control system, the possibility of using a PLC“Simens Logo” for multi-mode control of electromagnetic actuators of hammer is demonstrated.
Scientific substantiation and practical realization of selective comminution process of polymetallic mineral raw materials
Authors: Lieberwirth Holger , Popov Oleg , Aleksandrova Tatiana , Nikolaeva Nadezhda
Published: September 2020

The results of various methods of studying structural and texture characteristics, physical and mechanical properties determining the liberation of ore minerals are presented in the article. They allow to estimate the content of ore minerals in them, to analyze particle size distribution and spatial distribution of their grains, etc. These data provide more detailed information on the strength properties of ore and the possibility of selective comminution at the stage of study and design of beneficiation schemes. The analysis of mineralogical and geochemical composition as well as the results of technological research have shown that investigated copper-nickel ores satisfy the criteria of selective comminution.
Methodology for quantitative assessment of ecological efficiency of geotechnologies
Authors: Galchenko Yuriy , Ozaryan Julia
Published: September 2020

The article presents the results of work aimed at solving the problem of mining waste generation by creating a methodology of wastefree technology. According to the authors, the problem of solid mining waste can be solved by building a technology with a completely closed cycle of circulation of matter. An integral non-waste coefficient for the field development technology has been proposed, which is defined as the sum of local coefficients obtained for each technological level. By the value of the general coefficient, it is possible to estimate the relative amount of solid waste for an operating mining and processing enterprise, as well as to carry out a comparative analysis of the options considered at the design stage.
Modeling and methodology for calculating the strength of a man-made bottom in a system with self-destruction of ore for ecologically safe mining
Authors: Fedorov Evgeny , Bekbergenov Dosanbay , Jangulova Gulnar
Published: September 2020

The article discusses the features of technological solutions in the development of chromite deposits at great depths in difficult mining and geological conditions. For a system with self-destruction of ore, as well as for other similar systems, the weakest point in mining is the design of the block bottom, especially for the lower horizons, where the geomechanical situation deteriorates significantly, it becomes necessary to use more powerful supports or to erect artificial bottoms that can withstand acting loads exceeding the bearing capacity of metal supports of various modifications. The most promising solution in the conditions of development of fractured massifs is the geotechnology of creating an man-made bottom at the zone of extraction and delivery of ore mass, in the areas of conjugation overstrett and interstrett pillars, reinforced with multi-support reinforced concrete platforms, as a bearing structural element of the mining system with self-destruction of ore, which can withstand extremely high rock pressure. The article presents the results of calculating the strength of an artificial bottom in a system with selfdestruction of ore using numerical 3D modeling.
A new program for the hydraulic calculation of steam-water mixture pipelines in geothermal fields
Authors: Shulyupin Aleksandr , Chermoshentseva Alla , Varlamova Natalia
Published: September 2020

A new mathematical model of steam-water flow in a pipeline, which takes into account the gravitational effect and satisfies new challenges in the development of geothermal fields with two-phase transportation of the heat carrier is presented. Taking into account the gravitational effect in the upstream flows, a method based on the “drift model”, which determines the steam velocity averaged over the crosssection was used. A similar method is proposed for downstream flows, but it determines the water velocity averaged over the cross-section. In this case, analogs of empirical coefficients were used. These coefficients determined from the condition of equality of parameters calculated using different approaches in a horizontal flow. The model was verified, which showed positive results. The proposed model significantly expands the possibilities of hydraulic calculation of steam-water mixture pipelines in geothermal fields.
Hydrological consequences of changes forest cover on watersheds of the Amur river basin
Authors: Sokolova Galina , Verkhoturov Andrei , Hayasaka Hiroshi
Published: September 2020

Observing the geographic environment change of watersheds is very important for understanding problem of influence on streamflow, which ranks fourth out of 23 hydrological problems highlighted at Vienna Catchment Science Symposium in April 2018. Watersheds of the Middle and Lower Amur, where main part of streamflow is formed, are covered with forests of various structures. Annual forest fires in the Amur basin lead to sharp decrease in transpiration and summarize evaporation, an increase in volume and rate of surface streamflow (slope) into river beds and, as a consequence an increase in river runoff. An increase frequency of fires entails a change in forest species composition. Despite fact that species of the stand within watershed grow up in same conditions (environment, climate, weather, fires) – total value of the areas of coniferous forests has a decrease, in contrast to deciduous species. This is consistent with the conclusions of Russian hydrologists about shift in Russia of the boundaries of middle taiga on north, which is justified by them using climatic models. Reduction of coniferous forests, which have a deeper root system and larger area of contact with atmospheric precipitation, contributes to a faster runoff of rainwater, contributing an increase streamflow. Moreover, a positive trend is also noted in synchronous dynamics of peaks of rain floods on the Amur near Khabarovsk. This corresponds to assessment of spatio-temporal variations of global terrestrial water storage changes of the Amur according measurements of the Earth’s gravitational fields by GRACE satellite, carried out by foreign researchers. It has been suggested that with a descending trend in areas of coniferous forests, conditions will persist, contributing to increase in streamflow during the period of monsoon and frontal cyclonic rains.
Experiments with neutron induced neutron emission from U-235, Pu-239, and graphite
Authors: Danon Yaron , Blain Ezekiel , Mohindroo Kumar , Devlin Matt , J.Kelly Keegan , Gomez Jaime , O'Donnell John
Published: September 2020

A neutron induced neutron emission experiment was conducted as the Los Alamos Neutron Science Center (LANSCE) facility at Los Alamos National Laboratory (LANL). In this experiment, a sample was placed in a well collimated neutron beam and was surrounded by an array of 28 fast neutron detectors (EJ-309). The experiment was performed with a neutron flight path of 21.5 m from the source to the sample, and 1 m from the sample to the detectors. The neutron emission from the sample was measured as a function of neutron time of flight covering an incident energy range from 0.7- 20 MeV. The samples included U-235, Pu-239, carbon (graphite), and blanks that matched the encapsulation of the sample. The measured samples were constantly cycled in and out of the neutron beam. This type of experiment measures neutron emission from all reactions occurring in the sample such as fission and elastic and inelastic scattering. Similar to the methodology previously developed at RPI [1], the measurements were compared with detailed simulations of the experiment using different cross section evaluations for the sample. The observed differences can be attributed to the evaluated neutron cross section and angular distributions. The carbon sample was used as a reference to validate both the experiment and simulation methodology and showed good agreement between experiments and simulations. A review of the experimental setup, analysis methods, and some of the results will be presented.
Neutron production from thick LiF, C, Si, Ni, Mo, and Ta targets bombarded by 13.4-MeV deuterons
Authors: Takeshita Hayato , Watanabe Yukinobu , Nakano Keita , Manabe Seiya , Aoki Katsumi , Araki Naoto , Yoshinami Kosuke , Kin Tadahiro , Shigyo Nobuhiro , Koga Jun , Makise So , Yoshioka Tamaki , Tanaka Masaomi , Teranishi Takashi
Published: September 2020

Double-differential thick target neutron yields from LiF, C, Si, Ni, Mo, and Ta targets bombarded by 13.4-MeV deuterons were measured by using an EJ-301 liquid organic scintillator at the Center for Accelerator and Beam Applied Science, Kyushu University. The measured (d, xn) spectra were compared with the (t, xn) spectra measured by the other group at the same incident energy per nucleon (6.7 MeV/u) and theoretical model calculations by Particle and Heavy Ion Transport code System (PHITS) and DEUteron-induced Reaction Analysis Code System (DEURACS). Some bumps are observed in the (d, xn) spectra for low-Z target elements, while no specific structure was seen in the (t, xn) spectra. The PHITS calculation, in which the intra-nuclear cascade of Liége (INCL) and generalized evaporation model (GEM) were used, generally overestimates neutron spectra while the DEURACS calculation agrees with experimental ones fairly well.
What can we learn from (n,xnγ) cross sections about reaction mechanism and nuclear structure?
Authors: Kerveno Maëlle , Dupuis Marc , Borcea Catalin , Boromiza Marian , Capote Roberto , Dessagne Philippe , Henning Greg , Hilaire Stéphane , Kawano Toshihiko , Negret Alexandra , Nyman Markus , Olacel Adina , Party Eliot , Plompen Arjan , Romain Pascal , Sin Mihaela
Published: September 2020

Inelastic (n,n') cross section is a key quantity to accurately simulate reactor cores, and its precision was shown to need significant improvements. To bypass the experimental difficulties to detect neutrons from (n,xn) reaction and to discriminate inelastically scattered neutrons from those following the fission process in case of fissile targets, an indirect but yet powerful method is used: the prompt γ-ray spectroscopy. Along this line, our collaboration has developed the GRAPhEME setup, optimized for actinides, at the GELINA facility to measure partial (n,xn γ) cross sections, from which the total (n,xn) cross section can be inferred. (n,xn γ) experiments with actinides are still particularly challenging, as their structure presents a high level density at low energy, and the competing neutron-induced fission reaction contaminates the γ-energy distribution. New precise measurements of the partial (n,xn γ) cross sections provide a stringent test to theoretical model and offer a way to improve them. This is a path to a better determination of the total inelastic scattering cross sections. In this contribution we discuss modeling aspects of the 238U and 182W (n,n' γ) reactions, also measured with GRAPhEME, using the three codes TALYS, EMPIRE and CoH. We will highlight the needed/expected improvements on reaction modeling and nuclear structure input.
Neutron inelastic cross section measurements on 58,60Ni
Authors: Olacel Adina , Borcea Catalin , Boromiza Marian , Dessagne Philippe , Henning Gregoire , Kerveno Maëlle , Negret Alexandra , Nyman Markus , Plompen Arjan
Published: September 2020

A natural nickel sample was used at the GELINA (Geel Electron LINear Accelerator) neutron source of the European Commission, Joint Research Centre, Geel to measure the neutron inelastic cross sections. The GAINS (Gamma Array for Inelastic Neutron Scattering) spectrometer was employed to detect the emitted γ rays while a 235U fission chamber monitored the neutron flux. We report the preliminary production cross sections corresponding to the first transitions in 58,60Ni in comparison with previously reported data and with TALYS 1.9 calculations performed using the default input parameters.