bluuebunny/crossref_metadata_2025 huggingface dataset:
Reconstruyendo los paradigmas orientales de los estudios del discurso
Authors: Xu Shi-
Published: November 2019

En este trabajo sostengo que existen razones genuinas y condiciones importantes para reconstruir los paradigmas orientales de los estudios del discurso más allá de los enfoques actuales, universalistas pero centrados en Occidente. En primer lugar, muestro las limitaciones y las consecuencias humanas del proyecto proliferante del Análisis Crítico del Discurso (ACD) occidental. En segundo lugar, y más importante, identifico varias características de los discursos de Asia, África, Latinoamérica y otras comunidades subalternas, así como sus recursos académicos relevantes. Finalmente, para ilustrar las estrategias de este trabajo de reconstrucción, considero las maneras de forjar un enfoque chino para analizar discursos tanto propios como globales.
De “la conspiración de silencio” al reconocimiento de voces alternativas. Las violaciones a los derechos humanos en Chile según el Informe Valech (2003)
Authors: Oteíza Teresa
Published: November 2019

Este artículo examina ciertos patrones de la realización de voz del Informe de la Comisión Nacional sobre Prisión Política y Tortura (también conocido como Informe Valech), un discurso oficial producido por el Ministerio del Interior en el proceso de investigación de las violaciones a los derechos humanos cometidas por la dictadura militar (1973-1990). Desde la Teoría de la Valoración, entendida como una reorganización comprehensiva y sistemática de los recursos léxicogramaticales empleados para valorar la experiencia social, se postula que los autores del Informe Valech construyen un discurso heteroglósico en el que incluyen de manera inscrita una multiplicidad de voces implicadas en los hechos de tortura y prisión política. Asimismo, el trabajo demuestra que los autores recurren a recursos de extra-vocalización e intra-vocalización, que junto a la presencia de nominalizaciones instancian en diferentes grados posiciones alternativas en el discurso.
Preservación de biopsias obtenidas por colonoscopia en pacientes con cáncer colorrectal para análisis moleculares
Authors: Uribe-Echeverry Paula T. , Arturo-Arias Brenda L. , García-Restrepo Natalia , Betancur-Pérez Jhon F.
Published: November 2019

Introducción: los estudios relacionados con el análisis del ADN han marcado una pauta para los avances en las ciencias básicas y uno de los requisitos para la obtención de buenos resultados es la calidad del material genético extraído, en conjunto con el método empleado para la preservación de las muestras. Objetivo: comparar tres métodos de preservación de biopsias obtenidas por colonoscopia en pacientes con cáncer colorrectal con fines de uso en estudios de biología molecular. Materiales y métodos: se tomaron biopsias por colonoscopia a nueve pacientes con diagnóstico clínico de cáncer de colon, las cuales se preservaron en solución salina y dos solventes estabilizadores de ácidos nucleicos, RNAlater® y LifeGuard™ Soil Preservation Solution; se realizó extracción del ADN total a las nueve muestras y se verificó la concentración y la calidad del ADN extraído. Resultados: la extracción del ADN a las 24 horas, ocho días, quince días, un mes, seis meses, uno y dos años después de la toma de la muestra, mostró que el ADN de las biopsias preservadas en solución salina se presentaba con baja concentración y degradado a los ocho días, mientras que el preservado en soluciones comerciales estabilizadoras presentó una buena calidad y alta concentración. Por otro lado, la calidad del ADN fue verificada mediante la amplificación por reacción en cadena de la polimerasa (PCR) de un fragmento de ADN asociado al gen APC. Conclusiones: las soluciones LifeGuard™ y RNAlater® pueden ser usadas durante el transporte y conservación de tejidos humanos, y pueden ser recomendados para aquellos laboratorios que deseen preservar muestras con métodos diferentes al embebido de muestras en parafina o que no cuentan con métodos de conservación altamente eficientes como la criogénesis.
PERSPEKTIF NILAI PESANTREN: PENGEMBANGAN KUALITAS PRIBADI IDEAL KONSELOR
Authors: Sa’idah Ishlakhatus , Haq Annajih Moh. Ziyadul
Published: November 2019

The personal quality of the counselor is very supportive of the process and results of counseling activities. However, in practice there are still often some problems related to the counselor's personal, although there have been many expert formulations about the personal qualities of the counselor. This is due to the standards used in the formulation of the personal qualities of the Western formula counselors that are not in accordance with the socio-psychological conditions of the Indonesian people. So it is important to attempt to internalize the values ​​of local wisdom into the formulation of the personal qualities of the counselor. One approach that can be used is a formula that is explored from the values ​​of pesantren. The aim of the study is to develop the personal qualities of counselors based on the values ​​of pesantren. This study uses a library study approach. The values ​​of boarding schools that can be extracted into the formulation of the ideal personal qualities of the counselor include, (1) sincerity, (2) patience, (3) firm and respectful, (4) caution, (5) openness, (6) pious, (7) compassion, and (8) fair.
TINJAUAN MAQASHID SYARIAH TERHADAP KONSUMSI
Authors: Zaimsyah Annisa Masruri , Herianingrum Sri
Published: November 2019

The purpose of this paper to look at consumer ethics in the view of maqasid sharia, because of the high level of consumption of a Muslim who is not in accordance with Islamic principles. In consuming a Muslim must also look at the maslahah of the products consumed. Maqasid sharia is the basis for a Muslim to consume halal food. Maqosid sharia is very necessary to be described so as to provide an understanding of the rationale based on sharia for humanity to live according to Islamic law. In consuming consumer behavior, it must be based on what has been regulated by Islamic law, namely: consuming Halal and Service Goods which are permitted which are clearly halal and haram, consumption for life in the world and the hereafter, paying attention to expenditure patterns so that income and expenditure are balanced, unlimited human desires but consumption must be balanced, a standard of living that is simple and not extravagant, does not accumulate wealth, and considers halal and haram what is consumed. So that to meet primary, secondary and tertiary needs must be in accordance with Islamic principles.
PENYUSUNAN 10 KELOMPOK BAHAN VALIDASI SILANG PADA KASUS 197 TITIK CURAH HUJAN DI JAWA TIMUR
Authors: Kurniawan Andang , Tarmana Dede
Published: November 2019

Untuk mendapatkan gambaran spasial suatu parameter lingkungan, diperlukan penentuan metode interpolasi spasial terbaik. Permasalahan muncul karena terdapat banyak sekali jenis metode interpolasi spasial. Untuk menentukan metode interpolasi yang paling sesuai, dapat dilakukan teknik validasi silang. Interpolasi juga penting dalam analisis curah hujan bulanan. Pada kasus interpolasi spasial 197 titik pengamatan curah hujan di Jawa Timur, validasi silang dapat dilakukan dengan menghilangkan sepuluh persen data secara bergantian. Penyusunan bahan validasi silang penting untuk dikembangkan agar terhindar dari terkumpulnya atau berbatasan langsungnya antar titik yang dihilangkan. Tujuan dari studi ini adalah menyusun bahan validasi silang dan menguji kehandalannya. Data koordinat lintang dan bujur dari 197 titik didapatkan dari Stasiun Klimatologi Malang. Peringkat data digunakan sebagai basis penyusunan. Dari sepuluh kelompok bahan validasi silang, tujuh (tiga) grup akan  memiliki dua puluh (sembilan belas) data yang dihilangkan. Data yang dihilangkan dari kelompok pertama (sepuluh) adalah data bernomor urut digit terakhir satu (nol). Tiga pendekatan dilakukan untuk mendapatkan peringkat: koordinat saja, klastering, dan pemisahan. Klastering menggunakan jarak euklid tautan lengkap dengan variasi klaster 98, 65, dan 49. Metode pemisahan dilakukan dengan membagi terlebih dahulu titik ke dalam 20 (5x4) kotak. Untuk mengetahui penyebaran yang baik digunakan dua pendekatan, yaitu tidak adanya pertetanggaan terdekat dan jarak yang lebih jauh. Analisis visual dengan bantuan poligon voronoi, plot boks, dan indeks histogram digunakan. Dua indeks (SR dan IK) dikembangkan untuk mengetahui pergeseran distribusi. Pendekatan menggunakan pemisahan merupakan metode yang paling sesuai. Dengan menambahkan sepuluh modifikasi, didapatkan bahan validasi silang yang dapat digunakan untuk uji komparasi metode interpolasi.
KAJIAN PERTUMBUHAN AWAN HUJAN PADA SAAT BANJIR BANDANG BERBASIS CITRA SATELIT DAN CITRA RADAR (STUDI KASUS : PADANG, 2 NOVEMBER 2018)
Authors: Al Habib Abdul Hamid , Pradana Yoga Wahyu , Pangestu Dany , Winarso Paulus Agus , Sujana Jusa
Published: November 2019

Banjir besar kembali melanda enam kecamatan di kota Padang, Sumatera Barat pada tanggal 2 November 2018.  Banjir terjadi disebabkan oleh debit sungai yang meluap akibat hujan sangat lebat yang terjadi di bagian hulu dan hilir. Dampak banjir bandang tersebut mengakibatkan 600 rumah terendam banjir, 3 jembatan putus dan menelan korban jiwa. Karena dampak tersebut maka penelitian ini dilakukan untuk meninjau kondisi suhu permukaan laut, mean sea level pressure, nilai transport uap air, streamline, data citra satelit Himawari-8 dan data citra radar cuaca C-Band. Data diolah dalam bentuk grafik dan peta spasial kemudian dilakukan analisis deskriptif yang meliputi analisis temporal dan analisis spasial. Berdasarkan hasil analisis hujan sangat lebat yang terjadi di wilayah Padang dipicu oleh gangguan cuaca skala regional berupa adanya pola shearline atau komponen zona arah lintasan angin yang mengalami perubahan secara tiba-tiba yang sejajar dengan angin horizontal dan daerah tekanan rendah yang menimbulkan konvergensi di pesisir kota Padang, kemudian nilai transport uap air yang cukup tinggi yaitu kisaran antara 700-1100 Kg/ms-1 pada lapisan 1000-300 mb. Terjadinya hujan lebat seringkali terkait dengan keberadaan awan Cumulonimbus (Cb). Hal ini dikarenakan karakteristik awan Cb dengan dimensi yang besar serta mengandung banyak partikel presipitasi seperti  air dan kristal es. Kondisi ini didukung dengan keberadaan awan Cb berdasarkan analisis time series citra satelit Himawari-8 dan nilai reflektifitas radar berada pada nilai 45-60 dBz. Pada tanggal 2 November 2018, hampir seluruh awan hujan yang muncul mempunyai ketebalan lebih dari 7 km, dimana suhu puncak awan terendah mencapai nilai      -72.5°C.
POTENSI PANAS LAUT SEBAGAI ENERGI BARU TERBARUKAN DI PERAIRAN PAPUA BARAT DENGAN METODE OCEAN THERMAL ENERGY CONVERSION (OTEC)
Authors: Aprilia Erlita , Aini Althaf , Frakusya Ayu , Safril Agus
Published: November 2019

Energi listrik merupakan suatu hal yang sangat dibutuhkan dalam keberlangsungan kehidupan manusia. Kebutuhan akan energi listrik yang semakin meningkat dari waktu ke waktu memerlukan inovasi baru untuk menghasilkan energi listrik yang ramah lingkungan. Ocean Thermal Energy Conversion (OTEC) adalah metode untuk menghasilkan energi listrik menggunakan prinsip perbedaan temperatur antara laut dalam dan permukaan dengan selisih temperatur minimal sebesar 20C untuk menjalankan mesin kalor. Papua Barat merupakan salah satu provinsi di Indonesia dengan elektrifikasi yang masih rendah. Letak Indonesia yang berada di wilayah tropis dengan perbedaan suhu air laut yang tinggi memiliki potensi untuk memanfaatkan metode OTEC dalam menghasilkan energi listrik. Penelitian ini bertujuan untuk mengetahui potensi pemanfaatan OTEC di perairan sekitar Papua Barat. Data yang digunakan adalah data suhu air laut dalam dan permukaan periode tahun 1955 – 2012 di dua belas titik di perairan sekitar Papua Barat. Data tersebut diperoleh dari World Ocean Atlas 2013 yang kemudian diolah menggunakan perangkat lunak olah data dan Ocean Data View (ODV). Hasil olah data didapatkan nilai efisiensi terbesar yaitu 7,67% dan terkecil yaitu 7,21%.
EFEK PUPUK CAIR KALSIUM TERHADAP PERTUMBUHAN DAN PRODUKSI TANAMAN KENTANG (SOLANUM TUBEROSUM L.)
Authors: Dahang Donatus , Winardi Rafael Remit , Lubis Muhammad R.R.
Published: November 2019

The research effects of liquid calcium fertilizers on the growing and producing of potatoes (Solanum tuberosum L.) had properly done. The research was carried out on Lau Gumba Village, Berastagi Sub-district, Karo Regency, North Sumatra, December 2018- May 2019. Randomize Block Design with two factors i.e. Faktor I: Concentration of “BF” fertilizer, B0: control, B1: 2, 5 ml/96 ml of water, B2: 5 ml/ 96 ml of water, B3: 7, 5 ml/ 96 ml of water. Factor II: concentration of “BC” fertilizer, C0: control, C1: 1 ml/ 96 ml of water, C2: 2 ml/ 96 ml of water, C3: 3 ml/ 96 ml of water. The results of the study show that the concentration of the liquid calcium fertilizer had significantly impact (p < 0.05) to the growing and the production of tubers. The concentration of B3 (7,5 ml/96 ml of water) and C3 (3 ml/96 ml of water) had highest score 39.4 cm of plants’ height, The concentration of B3 (7, 5 ml/96 ml of water) and C3 (3 ml/96 ml of water) had significant impact to tubers’ weight.
PENYULUHAN BAHAYA NARKOBA TERHADAP ANAK – ANAK SD
Authors: Haerudin  , Tia Latifatu Sadiah  , Tarpan Suparman
Published: November 2019

Community Service is the goal to provide insight, knowledge and understanding of the types and dangers that can be caused during drug completion. The method used in this study is a method, question and answer, and developed through media images and videos. The results of this activity can be used by students from 10 to 90 about drugs, this can be seen when students ask students of SDN Wanajaya II, which students are expected to avoid drugs. Community Service Activities intersect with students who are Class 5 in SDN Wanajaya II running smoothly, students also pay close attention and look enthusiastic from beginning to end. Keywords : Narcotics Hazards, Types and their use

 

Pengabdian Kepada Masyarakat ini bertujuan untuk memberikan gambaran, pengetahuan dan pemahaman tentang jenis dan bahaya yang dapat ditimbulkan pada penyalahgunaan narkoba. Metode yang digunakan dalam kegiatan ini metode ceramah, tanya jawab, dan simulasi jenis jenis narkoba dan bahaya narkoba melalui media gambar dan vidio. Hasil dari kegiatan ini adalah dapat meningkatnya pemahaman siswa siswi dari 10 menjadi 90 tentang narkoba, hal ini terlihat ketika diberikannya kesempatan untuk bertanya kepada siswa siswi SDN Wanajaya II, yang nantinya siswa siswi diharapakan bisa terhindar dari narkoba. Kegiatan Pengabdian Pada Masyarakat ini penyuluhan pada sisw asiswi Kelas 5 SDN Wanajaya II berjalan lancar, sisiwa siswi juga memperhatikan dengan baik dan terlihat antusias dari awal sampai akhir. Kata Kunci : Bahaya Narkoba, Anak SD
PENERAPAN ASAS PEMBALIKAN BEBAN PEMBUKTIAN DALAM PENYELESAIAN SENGKETA KONSUMEN
Authors: Syam Misnar
Published: November 2019

Consumer dispute related to violation of the consumer rights by businessman. Article 45 of Consumer Protection Law provides that the dispute may be settled by out of court dispute settlement or through litigation. In Indonesia, out of court dispute settlement of consumer disputes is conducted under the authority of Consumer Disputes Settlement Body (BPSK), while in litigation mechanism exercised with submission by the consumer personally, class action, or NGO claim. Consumer dispute settlement is part of civil litigation. According to Article 163 HIR/ 283 RBg, the party who alleges that he has a right shall proof his allegation. While, according to Article 19(5) of Consumer Protection Law, the businessman may be exempted from its duty, if it can proof that the damages suffered by the consumer is because of the consumer fault itself. Therefore, the businessman must prove that it did not commit any fault (shifting the burden of proof). The principle of shifting the burden of proof has adopted by Consumer Protection Law because the consumer has no sufﬁ  cient knowledge of materials, production process, and distribution process which done by the businessman regularly. The Consumer Protection Law has no clear provision on the implementation of shifting the burden of proof, while the same situation is also found in Supreme Court Regulation No. 1 of 2006 concerning Appeal on the Judgment of BPSK. Thus, there are inconsistency implementations on the shifting of the burden of proof between on case by case. It depends on the comprehension knowledge of the judges. Such situation may lead to ineffective implementation of Consumer Protection Law.
The effects of gamification elements in e-learning platforms
Authors: Gafni Ruti , Biran Achituv Dafni , Eidelman Shimon , Chatsky Tomer
Published: November 2019

Gamification to perform tedious tasks in an enjoyable way is used in e-learning systems. This study examines in what manner gamification elements affect the e-learning experience in software studies. Two similar e-learning platforms were developed with the aim to teach basic Linux commands, one of them including gaming elements. One group (92 participants) studied using the gamified platform, and another group (47) using a non-gamified platform. The findings show that although the exam grades were not statistically different between the groups, the motivation to learn and continue learning after this experience was higher in the group using a gamified e-learning platform.
KRISTOLOGI KETUHANAN YESUS PADA ISU SLAVERY GAYA BARU: SUATU USAHA KONTEKSTUALISASI INJILI
Authors: Siburian Togardo
Published: November 2019

Tulisan ini adalah refleksi kontemporer atas doktrin ketuhanan Yesus pada situasiperbudakan gaya baru dewasa ini. Studi doktrinal Injili selama ini mengalamikemandegan dogmatisme, karena hanya pengulangan tema-tema abstrak tanpaterkait dengan kehidupan riil. Khususnya dalam pengaplikasian kristologi ketuhanan Yesus pada konteks segar, di mana kekristenan berada. Refleksi Injili sekarang terlalu menekankan kristologi “from above”dalam tema keilahian-Nya seperti: supremasi, keunikan, dan finalitas Kristus, tetapi melalaikan perspektif “from afore” pada dampak penebusan Kristus dalam kehidupan Kristen secara aktual. Kecenderungan hasilnya adalah pemisahan kejuruselamatan dari ketuhanan-Nya sampai pada pemisahan pengakuan dan praktik ketuhanan Yesus. Pada kondisi ini, tulisan aplikatif kontekstual Kristologi Injili hanya konsep superiorisme Kristus di atas oknum dan melawan isu-isu ideologis di sekitar kegerejaan masa kini. Di sini pentingnya reformulasi Kristologi Injili yang seimbang antara tematema keilahian dan isu kemanusiaan yang berfokus pada ketuhanan dan kejuruselamatan-Nya, keprihatinan apologetis dengan etis, kepercayaan konseptual dengan praktika, juga implementasi kristologis Injili yang parenialisme dalam kontekstualisme. Lalu mereartikulasikan ketuhanan Yesus yang teraplikasi dalam isu-isu kemanusiaan sekarang, berdasarkan hubungan hubungan komprehensif tema ketuhanan-Nya. Pada konteks ini ada kesempatan bagi kaum Injili untuk mengkontekstualisasikan doktrin Kristus (Kristologi) pada soal khusus, seperti perbudakan masa kini yang muncul lagi dalam gaya baru.
ECOTHEOLOGY DAN ECOPEDAGOGY: UPAYA MITIGASI TERHADAP EKSPLOITASI ALAM SEMESTA
Authors: Napitupulu Nurasyah Dewi , Munandar Achmad , Redjeki Sri , Tjasyono Bayong
Published: November 2019

Eksploitasi lingkungan hidup merupakan bentuk kekerasan terhadap alam semesta yang berkontribusi pada fenomena ekologis yang terjadi dewasa ini secara lokal dan global. Kerusakan lingkungan yang terjadi merupakan isu “sekuler” dan isu “religius” atau “teologis” terintegrasi yang memerlukan perspektif ecotheology dan ecopedagogy dalam mitigasinya. Tujuan penelitian ini adalah untuk menggambarkan sikap etis-teologis mahasiwa terhadap berbagai fenomena ekologis seperti pemanasan global, deforestasi, dan penggunaan sumber-sumber energi yang dieksplorasi melalui angket sebagai instrumen penelitian. Dengan sampel berjumlah 60 orang mahasiswa dengan latar belakang agama yang berbeda, hasil penelitian menunjukkan bahwa persentase rata-rata sikap mahasiswa adalah 61,2% dengan kategori kurang. Tidak ada perbedaan yang signifikan rata-rata sikap mahasiswa terhadap fenomena lingkungan berdasarkan agama. Disimpulkan bahwa latar belakang agama tidak berkontribusi membentuk sikap mahasiswa terhadap fenomena ekologis. Untuk meningkatkan dan memperbaharui sikap mahasiwa terhadap fenomena lingkungan perlu dipertimbangkan integrasi ecotheology dan ecopedagogy untuk mengkonstruksi pemahaman konsep mahasiswa terhadap fenomena ekologi
PENGARUH KOMPETENSI TERHADAP KINERJA KARYAWAN PADA PT. BANK DANAMON INDONESIA, TBK CABANG SIMPANG PASAR BAWAH
Authors: Dianita Nana
Published: November 2019

The purpose of this study was to determine the effect of competence on the performance of employees at PT. Bank Danamon Indonesia, Tbk Cabang Simpang Pasar Bawah. The sample in this study were all employees at PT. Bank Danamon Indonesia, Tbk Cabang Simpang Pasar Bawah totaling 34 people. While the variables studied in this research is the competence and performance. Analysis of data using simple linear regression method using validity, reliability, R2 and t test. The tests are conducted to determine the relationship between the independent variables (independent variables) and dependent variable (dependent variable). Based on research results the effect of competence on the performance of employees with correlation value R = 0,656 which indicates a close relationship between the effect of competence on the performance of employees at PT. Bank Danamon Indonesia, Tbk Cabang Simpang Pasar Bawah. While the R-square at 0,430 which can competence has contributed of 43% to the performance of employees at . Bank Danamon Indonesia, Tbk Cabang Simpang Pasar Bawah. Partially acquired competence variable positive and significant effect on the performance employees at . Bank Danamon Indonesia, Tbk Cabang Simpang Pasar Bawah with simple linear regression equation as follows: Y = 18,342 + 0,627X significantly smaller 0,000 than alpha 0,05. The conclusion of this study that partial hypothesis between variables competence on performance employees is proven and can be accepted as true
In Vitro and In Vivo Efficacy of Non-Psychoactive Cannabidiol in Neuroblastoma
Authors: Fisher T. , Golan H. , Schiby G. , PriChen S. , Smoum R. , Moshe I. , Peshes-Yaloz N. , Castiel A. , Waldman D. , Gallily R. , Mechoulam R. , Toren A.
Published: November 2019

Background: Neuroblastoma (NBL) is one of the most common solid cancers in children. Prognosis in advanced NBL is still poor despite aggressive multimodality therapy. Furthermore, survivors experience severe long-term multi-organ sequelae. Hence, the identification of new therapeutic strategies is of utmost importance. Cannabinoids and their derivatives have been used for years in folk medicine and later in the field of palliative care. Recently, they were found to show pharmacologic activity in cancer, including cytostatic, apoptotic, and antiangiogenic effects. Methods: We investigated, in vitro and in vivo, the anti-NBL effect of the most active compounds in Cannabis, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). We set out to experimentally determine the effects of those compounds on viability, invasiveness, cell cycle distribution, and programmed cell death in human NBL SK-N-SH cells. Results: Both compounds have antitumourigenic activity in vitro and impeded the growth of tumour xenografts in vivo. Of the two cannabinoids tested, CBD was the more active. Treatment with CBD reduced the viability and invasiveness of treated tumour cells in vitro and induced apoptosis (as demonstrated by morphology changes, sub-G1 cell accumulation, and annexin V assay). Moreover, CBD elicited an increase in activated caspase 3 in treated cells and tumour xenografts. Conclusions: Our results demonstrate the antitumourigenic action of CBD on NBL cells. Because CBD is a nonpsychoactive cannabinoid that appears to be devoid of side effects, our results support its exploitation as an effective anticancer drug in the management of NBL.
Current and Emerging Biomarkers in Metastatic Colorectal Cancer
Authors: Lee M.K.C. , Loree J.M.
Published: November 2019

Background: The incorporation of novel biomarkers into therapy selection for patients with metastatic colorectal cancer (mcrc) has significantly improved outcomes. Optimal treatment planning now takes into account diverse characteristics of patients and their tumours to create personalized therapeutic plans. Discussion: This review is split into two sections. In the first section, we review the prognostic and predictive significance of expanded RAS mutation testing, BRAF mutations, ERBB2 (her2) amplification, microsatellite instability (msi) and deficient mismatch repair (dmmr) protein, NTRK fusions, PIK3CA mutations, and met amplifications. The therapeutic implication of each of those biomarkers for personalizing therapies for each patient with mcrc is discussed. In the second section, we touch on testing methods and considerations of relevance to clinicians when they interpret companion diagnostics meant to guide therapy selection. The advantages and pitfalls of various methods are evaluated, and we also look at the potential of liquid biopsies and circulating tumour dna (ctdna) to change the landscape of therapeutic choice and biologic understanding of the disease. Summary: Routine testing for extended RAS, BRAF, dmmr or high msi, and NTRK fusions is necessary to determine the best sequencing of chemotherapy and biologic agents for patients with mcrc. Although next-generation sequencing and ctdna are increasingly being adopted, other techniques such as immunohistochemistry retain their relevance in detection of her2 amplification, NTRK fusions, and dmmr.
Preparation of anthracene-based tetraperimidine hexafluorophosphate and selective recognition of chromium(III) ions
Authors: Liu Qing-Xiang , Yang Feng , Zhao Zhi-Xiang , Yu Shao-Cong , Ding Yue
Published: November 2019

A novel anthracene-based tetraperimidine hexafluorophosphate 3 was prepared, and its structure was determined through X-ray analysis, HRMS as well as 1H and 13C NMR spectroscopy. In the cationic moiety of 3, two (N-ethylperimidinyl–C2H4)2NCH2– arms were attached to the 9- and 10-positions of anthracene. In addition, compound 3 was used as a chemosensor to research the ability to recognize Cr3+ through fluorescence and UV titrations, HRMS, as well as 1H NMR and IR spectroscopy. The results indicate that 3 is an effective chemosensor for Cr3+.
O que você já deixou de fazer por ser mulher? Relato de uma experiência
Authors: Ferreira Michel Alves , Paringer Talita Ketylin Costa Cabral , Casagrande Lindamir Salete Salete
Published: November 2019

O objetivo deste relato de experiência é apresentar uma análise sobre os depoimentos demulheres que de alguma forma se relacionaram com a UTFPR, campus Curitiba, no mês demarço de 2016. O estudo foi baseado nos painéis produzidos na intervenção desenvolvidapelo Núcleo de Gênero e Tecnologia – GETEC, durante o “II Mês da Mulher da UTFPR –Mulheres Vencendo desafios”, onde as mulheres (e alguns homens) deixaram os seusrelatos respondendo a seguinte pergunta: “O que você já deixou de fazer por ser mulher?Foram analisados os relatos dessas pessoas, especialmente as mulheres (alunas,professoras, técnicas administrativas, trabalhadoras terceirizadas, dentre outras) sobresuas experiências pessoais e institucionais, buscando evidenciar suas opiniões e interpretarsuas falas sob a lente de gênero. Em um segundo momento, apresentamos os depoimentoscolhidos junto às/aos organizadoras/es da intervenção para captar suas impressões sobreos impactos da atividade, por categorias. Com base nesta análise foi possível perceber anecessidade das mulheres têm de encontrar espaços nos quais possam manifestar suasopiniões, se expressar de forma livre e espontânea, espaços nos quais possam dizer o querealmente pensam a respeito de serem mulheres e as consequências de que este fato temem suas vidas. A intervenção evidenciou a necessidade de criação de espaços queviabilizem, com maior frequência, este diálogo dentro da universidade.
O desenvolvimento das personagens leitoras nos romances Madame Bovary e A carne
Authors: Guimarães Veridiana De Souza , Guimarães Rafael Eisinger
Published: November 2019

O presente estudo tem por objetivo entender a influência da leitura no desenvolvimento das personagens Ema Bovary e Lenita Matoso, dos romances Madame Bovary, de Gustave Flaubert (1971), e A carne, de Júlio Ribeiro (1952), respectivamente. A partir da análise das duas obras literárias, buscamos identificar como a vivência com os livros influenciou nas atitudes das jovens protagonistas, assim como entender o modo como a leitura é descrita nessas obras literárias. Para embasar esta leitura, no referencial teórico nos apropriamos dos conceitos de diversos pensadores, dentre eles Roger Chartier (2001), Aristóteles (1973), Vincent Jouve (2002), Simone de Beauvoir (1980), Rita Terezinha Schmidt (2012) e Nádia Elisa Meinerz (2012). A fim de examinar a relação entre a leitura, as personagens femininas e a desigualdade de gênero, realizamos o processo de análise por meio da comparação das obras literárias citadas. Feito isso, constatamos, a partir da vivência das personagens leitoras de Flaubert e Ribeiro, que a leitura era vista como algo perigoso para as mulheres do século XIX.
Mulheres que contam
Authors: MASCARENHAS MÁRCIA GABRIELLE BRITO
Published: November 2019

O seguinte texto pretende fazer uma resenha acerca da palestra de Chimamanda e da performance de Verônica Bonfim, traçando elementos comparativos entre as duas pensadoras.
As duas extremidades dos Sistemas de Informação (SI) e as questões relacionais de gênero
Authors: Rocha Cristina Tavares da Costa , Carvalho Marília Gomes de
Published: November 2019

Os Sistemas de Informação (SI) apresentam duas extremidades. Em uma, há @s produtor@s de softwares (SW), iniciador@s do processo que se desencadeia, tanto de informação, de intercâmbio, quanto de outras atividades, como programação de portais na Internet, por exemplo. Na outra, há @s usuári@s finais dos SI. Este estudo objetiva tecer reflexões a partir das abordagens relacionais de gênero sobre atividades desenvolvidas nessas duas extremidades, visando a detectar se há diferenças significativas entre ess@s atores/atrizes nos cenários digitais no que se refere a produzir x usar as novas tecnologias da informação e da comunicação.
Sobre os estudos em masculinidades no Brasil: revisitando o campo
Authors: Galvão Adrião Karla
Published: November 2019

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Divisão sexual do trabalho: as contradições dos discursos entre capital e trabalho no interior da fábrica
Authors: Regina Resnauer Taques da Silva Dias Vera , Gomes de Carvalho Marilia , Marcos Dias Garcia Nilson
Published: November 2019

Investigou-se, com esta pesquisa como ocorre a divisão sexual do trabalho no capitalismo contemporâneo a partir de sua constituição histórica. Examinou-se esses aspectos relacionando-os com as formas de organização do trabalho fabril em uma indústria de eletrodomésticos, em Curitiba. A pesquisa foi qualitativa, por meio de entrevistas realizadas com trabalhadores(as) da área de produção e com uma profissional da área de RH. Os objetivos foram: conhecer como a empresa emprega o trabalho feminino no setor fabril; qual a percepção que trabalhadores/as têm das características do trabalho que realizam. Para tanto, abordou-se as relações de gênero no âmbito da crise do trabalho abstrato, decorrente da reestruturação da produção capitalista. Constatou-se a existência de um grau de divisão sexual do trabalho que coloca a mulher em condição subalterna em relação ao homem. Em muitos casos as funções são as mesmas, porém os cargos e a remuneração são diferentes, com menor prestígio e menor valor.
Construcción de valores y diferencias mediante la literatura infantil: género y diversidad sexual en la escuela
Authors: Souza Batista Tortato Cíntia , Salete Casagrande Lindamir , Gomes de Carvalho Marilia
Published: November 2019

Este artigo trata do objetivo, metodologia e resultados de um curso de extensão universitária que foi realizado com profissionais de educação, professora(e)s ou não, do Município de Matinhos, no Estado do Paraná – Brasil. Dentre os objetivos do curso estavam a necessidade de sensibilizar as/os participantes sobre a importância de se pensar as questões de gênero e diversidade sexual na escola, propor algumas formas de abordagem do assunto e sistematizar a experiência em forma de produção científica. Uma das formas de abordar as questões de gênero e a diversidade sexual foi a utilização de livros de literatura infantil, tema deste artigo. Sem reduzir a função da literatura infantil às questões pedagógicas, mas, reconhecendo sua riqueza e sua posição privilegiada como artefato cultural que pode transmitir valores e perspectivas, bem como, construir saberes, nos valemos de alguns livros, escolhidos propositadamente, para abordar de forma lúdica e sensível os valores e as construções culturais em torno dos gêneros, sexos, sexualidade e diferenças no intuito de problematizá-las. Na execução da atividade foram feitas as leituras de alguns livros para as/os participantes do curso e em seguida, estes participantes foram dispostos em grupos e receberam outros livros para que se posicionassem quanto à pertinência ou não de cada livro no trabalho escolar. Como resultado desta experiência, foi possível perceber que: 1- o uso de literatura infantil pode abrir inúmeras possibilidades de trabalho em sala se aula; 2- as/os participantes demonstraram interesse e entusiasmo na execução desta atividade; 3- por meio das falas delas e deles pode-se perceber a motivação proporcionada pelas leituras e as possibilidades reais de minimizar os preconceitos e desigualdades; 4- por meio do reconhecimento das diferenças, pode-se construir relações sociais e valores mais igualitários desde a infância.
A invisibilidade dos transexuais na educação: análise dos discursos legais sobre o nome social nas escolas do Brasil
Authors: Lessa Patrícia , Oliveira Marcio
Published: November 2019

O processo de transexualização ainda é uma discussão recente no Brasil, pouco ou nada se fala sobre as/os transexuais. Sua invisibilidade nos espaços educacionais é notável. Este estudo objetiva analisar os discursos do Conselho Federal de Medicina (CFM) confrontando-os com os discursos da recente legislação do “nome social” que está em vigor nas escolas públicas brasileiras. Como procedimento de coleta de dados, usamos o método documental. Os saberes tecnobiomédicos e jurídicos identificam na cirurgia de correção da genitália formas de normalização dos corpos. A transexualidade apresenta-se como uma interrogação radical não somente sobre os processos de identificação, mas, também, sobre a noção de identidade sexual. A desconstrução de gênero se faz presente mesmo na tentativa de enquadrá-la às normas e ditames da heteronormatividade. Daí decorre a importância desse estudo para educação.
O direito de autonomia: gênero e justiça social em sociedades democráticas
Authors: Santos Júnior Jaime
Published: November 2019

A emergência de demandas oriundas de diferentes movimentos sociais nas últimas décadas ensejou uma re exão no interior das ciências sociais acerca da forma como tais demandas poderiam ser equacionadas. Isto porque o conteúdo universalista dos princípios republicanos é confrontado com o pluralismo de valores de onde emanam as reivindicações de tais movimentos. É neste contexto que são formuladas políticas especí cas para a promoção da autonomia das mulheres; uma delas é o ingresso no mercado de trabalho. Se a relação entre acesso a um emprego e autonomia feminina nem sempre é clara, mobilizamos nesse texto o argumento rawlsiano de justiça social como um recurso analítico fecundo para se pensar como tais demandas podem ser agenciadas em sociedades democráticas.
Gênero, ciência, tecnologia e desenvolvimento: as concepções dessas categorias nos documentos fundantes do PROEJA
Authors: Terezinha Covolan Nadia , Lúcia Buher Machado Maria
Published: November 2019

Neste trabalho, discutimos as categorias Ciência, Tecnologia e Gênero conforme constam nos documentos fundantes do PROEJA (Programa Nacional de Integração da Educação Pro ssional com a Educação Básica na Modalidade de Educação de Jovens e Adultos), promulgado pelo Ministério de Educação e Cultura e implantado em vários Institutos de Educação Técnica e Tecnológica do Brasil, a partir de 2007. Este programa tem como objetivo, além da formação pro ssional, a educação plena para o exercício da vida cidadã, de minorias sociológicas. Nesse contexto, argumentamos sobre as possibilidades e limites do PROEJA especialmente para as mulheres, porque estas somam as desigualdades de oportunidades para formação escolar e pro ssional com as assimetrias de poder nas relações de gênero, o que compromete o acesso mais equitativo a técnicas e tecnologias libertárias e aos bens socialmente construídos. Por m, re etimos sobre a vinculação das categorias com vistas ao desenvolvimento pessoal e o das comunidades envolvidas.
Preconceito e discriminação: a vivência de cursistas do GDE
Authors: Daniella de Almeida Kaciane , Bueno de Freitas Lucas , Stancki da Luz Nanci
Published: November 2019

O objetivo deste artigo é apresentar os resultados de uma pesquisa feita junto a cursistas da edição 2013/2014 do curso de formação de professores/as “Gênero e Diversidade na Escola” (GDE), ofertado pela Universidade Tecnológica Federal do Paraná (UTFPR) por meio do Núcleo de Gênero e Tecnologia (GeTec), do Programa de Pós-graduação em Tecnologia e Sociedade (PPGTE). Foi questionado às/aos cursistas se elas/es observavam, em suas respectivas escolas ou ambientes de trabalho, situação de desrespeito ou discriminação quanto ao gênero, raça/etnia ou sexualidade; as respostas desta questão são objetos de análise deste artigo. Como resultado, revela-se, a partir da vivência das/os cursistas, a importância do GDE como instrumento na formação para os/as docentes, que a cada dia mais reconhecem as diversas situações de preconceitos e discriminações em relação ao gênero, à sexualidade, à diversidade sexual e às relações étnico/raciais que perpassam o ambiente escolar e sentem a necessidade de enfrentamento dessas questões.
Contrastes e similaridades: um olhar de gênero sobre cursos de engenharias e licenciaturas da UTFPR e da UFBA
Authors: Salete Casagrande Lindamir , Maria Freire de Lima e Souza Ângela
Published: November 2019

O objetivo deste artigo é apresentar dados relativos à participação masculina e feminina nos cursos de Engenharia Civil e Mecânica e Licenciaturas em Letras e Matemática da UTFPR e da UFBA. Para este estudo, utilizaremos o método quantitativo com base em informações obtidas junto às duas instituições. Os resultados aqui apresentados integram a primeira etapa da pesquisa para a realização do estágio de pós-doutorado junto ao Programa de Pós-Graduação em Estudos sobre Mulheres, Gênero e Feminismo – PPGNEIM da Universidade Federal da Bahia – UFBA, cujo objetivo é analisar as engenharias e licenciaturas da UTFPR e UFBA sob a perspectiva de gênero. O estudo compreende duas etapas: a primeira, de cunho quantitativo, visa construir o panorama desta participação nos referidos cursos e tem os resultados aqui apresentados. A segunda etapa, de enfoque qualitativo, pretende conhecer os motivos pelos quais homens e mulheres optam por um ou outro curso, bem como as dificuldades e facilidades enfrentadas por eles e elas para se manter nos cursos escolhidos, considerando seus respectivos contextos socioculturais. Os dados apontam que as mulheres são a minoria nas Engenharias, de modo especial na Engenharia Mecânica onde os números raramente atingem 15%. No que tange as licenciaturas, elas são maioria absoluta em Letras, porém em Matemática os números oscilam bastante e ficam próximos. É importante demarcar que diferenças regionais e/ou culturais parecem não alterar a distribuição desigual de homens e mulheres nos cursos analisados, em duas instituições contrastantes em muitos aspectos. Os resultados aqui apresentados indicam a relevância da realização da segunda etapa da pesquisa.
Gina D`Mascar: a performance do ridículo
Authors: De Freitas Ribeiro Andressa , De Freitas Ribeiro Andressa
Published: November 2019

O presente trabalho consiste em uma descrição de dois episódios centrados em uma Drag Queen cujo nome é Gina D’ Mascar. Gina D’Mascar é uma personagem extremamente original e que quebra todos os estereótipos da Drag Queen tradicional; possui uma aparência exagerada que beira o ridículo – a maquiagem carregada, o cabelo disforme, o corpo grande e cheio e os dentes pintados dando a aparência de que estão estragados. Gina D’ Mascar se apresenta toda quarta-feira em um espaço de sociabilidade LGBTTT denominado Beco dos Artistas localizado na cidade de Salvador-Ba. O Beco sempre foi um lugar povoado de personagens ricos para pensar as temáticas de gênero, corpo e sexualidade, dentre essas personagens está a Drag Queen Gina D`Mascar.
A Hybrid Active Contour Model based on New Edge-Stop Functions for Image Segmentation
Authors: Yang Xiaojun , Jiang Xiaoliang
Published: November 2019

Edge-based active contour methods are popular algorithms for image segmentation, with the purpose to extract the area of interest. However, they may face to boundary leakage and improper segmentation when handle images under weak edges or complex shapes. The extensive edge-stop functions adopt edge information, which cannot apply to guide the evolving curve approaching to target boundaries. To resolve this issue, a novel level set algorithm based on non-local means (NLM) filtering is constructed in this study. Firstly, the images are subjected to non-local means filtering to generate edge map. Secondly, a new edge-stop function constructed from this edge map as well as the fuzzy k-NN classification algorithm is incorporated into the variational model. Our experiments demonstrate that non-local means filtering is able to sharp edges both on medical and natural images. Thus, this analysis seems to be useful for clinical medical diagnosis.
Secure In-Network Aggregation in Wireless Sensor Networks
Authors: Maivizhi Radhakrishnan , Yogesh Palanichamy
Published: November 2019

In-network aggregation is a natural approach in wireless sensor networks (WSNs) to collaboratively process data generated by the sensor nodes. Besides processing, in-network aggregation also achieves effective energy consumption and bandwidth utilization. Since the sensing devices of a WSN are prone to a variety of attacks due to wireless communication and limited resources, secure in-network aggregation is a great challenge. This article proposes a secure in-network aggregation (SINA) protocol for additive aggregation functions. This protocol integrates privacy homomorphism (PH) and secret sharing to achieve both data confidentiality and data integrity. Additionally, the proposed protocol ensures message authentication and data freshness. Moreover, it achieves false data screening in-network should be changed as in-network false data screening which considerably saves energy by not transmitting false packets. Security analysis reveals that SINA protects the network from variety of attacks. Performance analysis shows that SINA consumes less energy while achieving end-to-end security, and thereby increases the lifetime of the WSN.
Patients' perceptions of pulmonary problems and nursing interventions during hospitalization for Pneumocystis carinii pneumonia
Authors: Janson-Bjerklie S , Holzemer W , Henry SB
Published: November 2019

BACKGROUND AND METHODS: The descriptive, correlational study examined patients' perceptions of pulmonary problems and nursing interventions in a sample (n = 201) of persons living with AIDS hospitalized for Pneumocystis carinii. Additionally, the study assessed differences in physiological variables, patient symptoms, and functional status based on the type of problems identified: dyspnea, pulmonary problems without dyspnea, and nonpulmonary problems. RESULTS: A total of 601 problems was identified including 61 instances of dyspnea and 83 reports of other pulmonary problems. The remainder of the problems was nonpulmonary. Nursing interventions associated with dyspnea and pulmonary problems other than dyspnea were mainly broadly defined interventions such as oxygen and medication administration. When patients were placed into three groups based on identification of dyspnea, pulmonary problems without dyspnea, or only nonpulmonary problems, there were no differences between groups in functional status or patient symptoms of pain, nausea, or fatigue as measured by the Quality Audit Marker. CONCLUSIONS: This study demonstrated that hospitalized patients with Pneumocystis carinii present with a broad array of problems. Contrary to expectations, dyspnea was not ubiquitous but was reported by less than one-third of this sample. When dyspnea was present there were few independent nursing interventions that patients identified. Studies are needed to test effective strategies for the nursing management of dyspnea and a large variety of other patient problems associated with HIV infection.
Adult respiratory distress syndrome: a consideration with rapid respiratory decompensation in association with preeclampsia
Authors: Papadakos PJ , Johnson DS , Abramowicz JS , Sherer DM
Published: November 2019

Adult respiratory distress syndrome, presenting as rapid respiratory decompensation in the setting of preeclampsia at 36 weeks of gestation, was managed by early hemodynamic monitoring with pulmonary artery catheterization. With confirmation of the diagnosis of preeclampsia the patient was delivered promptly; improvement of her respiratory failure was observed within 48 hours. Consideration of adult respiratory distress syndrome in the setting of preeclampsia is discussed, with emphasis on early confirmation of the diagnosis and determination of the precise mechanisms of pulmonary edema.
Effects of neck position on intracranial pressure
Authors: Williams A , Coyne SM
Published: November 2019

OBJECTIVE: To investigate the effects of four nonneutral neck positions on intracranial pressure. DESIGN: An alternating treatment design was used to investigate the effect on intracranial pressure of rotation of the head to the left and right, neck flexion and neck extension. Each experimental position was separated by a neutral recovery period. SETTING: Neurological intensive care units in two tertiary care centers in the southwestern United States. SUBJECTS: Ten patients whose intracranial pressure was being therapeutically monitored but who were not experiencing prolonged periods of elevated intracranial pressure. PROCEDURE: Each neck position was maintained manually by the research staff for 5 minutes. Intracranial pressure was recorded at 1-minute intervals throughout the 45-minute data collection period. RESULTS: Rotating the head to the right and left and placing the neck in flexion resulted in significantly higher intracranial pressure readings than the baseline neutral neck position or positioning the neck in extension. The highest individual intracranial pressures always occurred with the head and neck rotated or in flexion. CONCLUSIONS: These data support previous studies that indicated that a patient at risk for pathological increase in intracranial pressure should not be positioned with the neck in flexion or the head turned to either side.