bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and Molecular Features of Disseminated Pediatric Low Grade Glioma - A Systematic Review of Literature
Authors: Haizel-Cobbina Joseline , Thakkar Rut , Richard Kelsey , Levine Adrian , Bennett Julie , Hawkins Cynthia , Tabori Uri , Dewan Michael C.
Published: December 2021

INTRODUCTIONGliomas account for approximately 46% of all pediatric CNS tumors. There is growing awareness of pediatric low-grade gliomas (PLGG) that disseminate to distant parenchymal or leptomeningeal locations either at the time of initial diagnosis or upon disease surveillance. Disseminated PLGGs (dPLGGs) are associated with a poorer prognosis than non-disseminated PLGGs. To date there is no comprehensive report characterizing the genome profile of dPLGGs and their associated management. This systematic review aims to identify the pattern of genetic alterations and treatment outcomes described for dPLGG.METHODSA systematic review of the literature was performed to identify relevant articles. A quality and risk of bias assessment of articles was done using the GRADE framework and ROBINS-I tool, respectively.RESULTSFifty-two studies published from 1994 to 2020 were included in this review with 368 cases reported. There was sporadic reporting of genetic alterations. The most common genetic alteration observed among study subjects was 1p deletion (76%) and BRAF-KIAA1549 fusion (55%). BRAF p.V600E mutation was found in 7% of subjects. A higher proportion of cases demonstrated primary dissemination compared to secondary dissemination (65% vs 25%). First-line chemotherapy consisted primarily of an alkylation-based regimen and vinca alkaloids. Surgical intervention ranged from biopsy alone to surgical resection and CSF diversion, and depended largely upon tumor location and timing of dissemination. Overall, 73% of cases were alive at last follow-up (median, 40.2 months). All studies reviewed either ranked low or moderate for both quality and risk of bias assessments. CONCLUSIONWhile 1p deletion and BRAF-KIAA1549 fusion are the most commonly described molecular alterations in dPLGG, these tumors appear to express heterogeneous molecular and biological characteristics distinct from non-disseminated PLGGs. Additional studies on the molecular and biological features of these tumors are needed to better understand the pathogenesis of dPLGG and to inform the development of additional targeted regimens.
Metabolomics Profile in Acute Respiratory Distress Syndrome By Nuclear Magnetic Resonance Spectroscopy In Patients With Community-Acquired Pneumonia
Authors: Yan Yongqin , Chen Jianuo , Liang Qian , Zheng Hong , Ye Yiru , Nan Wengang , Gao Hongchang , Li Yuping
Published: December 2021

Background: Acute respiratory distress syndrome (ARDS) is a challenging clinical problem. To date, no standardized diagnostic biomarker has been validated for community-acquired pneumonia (CAP)-induced ARDS. An integrated analysis of changes in the metabolic profile could help detect biomarkers for early prediction of ARDS development and evaluation of treatment efficacy.Methods: A total of 88 patients were enrolled for the final analysis and divided into two groups: the ARDS group (n = 43) and the no-ARDS group (n = 45). We examined differences in serum and urine metabolites and explored dynamic changes with nuclear magnetic resonance (NMR) spectroscopy.Results: A total of 20 serum and 42 urine metabolites were identified using NMR spectroscopy. Serum metabolites, including leucine, 3-hydroxybutyrate, lactate, acetone, citrate, and choline, and urine metabolites, including creatine and creatinine, could distinguish patients with CAP with and without ARDS, with areas under the receiver operating characteristic curve (AUC) values of 0.790 and 0.747, respectively. The treatment efficacy of patients with ARDS was achieved at an AUC of 0.862 with serum metabolites 3-hydroxybutyrate, lactate, acetone, acetoacetate, citrate, and choline, and of 0.691 with urine metabolites taurine and glucose. The treatment efficacy of patients without ARDS was achieved at an AUC of 0.845 with serum metabolites alanine, acetate, acetoacetate, glutamine, creatine, and glucose and 0.891 with urine metabolites choline, tryptamine, and 3-indoxyl sulfate. We also proposed a combined biomarker of associated serum and urine metabolites to predict ARDS in patients with CAP (AUC = 0.865) and evaluate treatment efficacy for patients with and without ARDS (AUC = 0.921 and 0.893, respectively).Conclusions: Serum and urine analyses showed that metabolomics provides potential circulatory markers for early prediction and evaluation of treatment efficacy in patients with CAP with and without ARDS.
The Effect of Cognitive Functional Therapy for Chronic Nonspecific Low Back Pain: Systematic Review and Meta-analysis
Authors: Miki Takahiro , Kondo Yu , kurakata Hiroshi , Buzasi Eva , Takebayashi Tsuneo , Takasaki Hiroshi
Published: December 2021

BackgroundTo apply the Bio-Psych-Social (BPS) model into clinical practice, it is important not to focus on psychosocial domains only since biomedical factors can also contribute to chronic pain conditions. The cognitive functional therapy (CFT) is the management system based on the BPS model for chronic nonspecific low back pain (CNSLBP). ObjectivesTo compare CFT with the other interventions for CNSLBP regarding pain, disability/functional status, QoL and psychological factors. DesignSystematic review and meta-analysis. MethodLiterature Search was conducted in electronic search engines. Enrolled participants included 1) CNSLBP and 2) primary, secondary, or tertiary care patients. CFT was the interventions included. Comparisons were any types of treatment. ResultsThree studies met the eligibility criteria. The total number of participants was 336. For pain intensity, MD [95% CIs] was -2.78 [-2.78−0.02] and -1.01 [-1.92−-0.10] at intermediate and long term for two studies, respectively. About disability/functional status, SMD [95% CIs] was -0.76 [-1.46−-0.07]　at the intermediate for three studies and MD [95% CIs] was -0.84 [-11.47−-5.49] at long term for two studies. About fear of physical activity, MD [95% CIs] was -3.01 [-5.14−-0.88] and -3.56 [-6.43−-0.68] at intermediate and long term for two studies, respectively. No studies reported scores associated with QOL. All the quality of the evidence was very low. ConclusionsThree studies were included and the quality of all the evidence was very low. Although the study found statistically significant differences in some measures, the effectiveness of the CFT will need to be re-evaluated in the future.PROSPERO registration number CRD42020158182
Divergent Design of Mechanical Metamaterials Clan Deducted from Arc-serpentine Curve
Authors: Mi Shengli , Yao Hongyi , Zhao Xiaoyu , Sun Wei
Published: December 2021

The exotic properties of mechanical metamaterials are determined by their unit-cells' structure and spatial arrangement, in analogy with the atoms of conventional materials. Companioned with the mechanism of structural or cellular materials1–5, the ancient wisdom of origami6–11 and kirigami12–16 and the involvement of multiphysics interaction2,17,18 enrich the programable mechanical behaviors of metamaterials, including shape-morphing8,12,14,16,19, compliance4,5,8,17,20, texture2,18,21, and topology11,18,22−25. However, typical design strategies are mainly convergent, which transfers various structures into one family of metamaterials that are relatively incompatible with the others and do not fully bring combinatorial principles3,10,26 into play. Here, we report a divergent strategy that designs a clan of mechanical metamaterials with diverse properties derived from a symmetric curve consisting of serpentines and arcs. We derived this composite curve into planar and cubic unit-cells and modularized them by attaching magnetics. Moreover, stacking each of them yields two- and three-dimensional auxetic metamaterials, respectively. Assembling with both modules, we achieved three thick plate-like metamaterials separately with flexibility, in-plane buckling, and foldability. Furthermore, we demonstrated that the hybrid of paradox properties is possible by combining two of the above assembles. We anticipate that this divergent strategy paves the path of building a hierarchical library of diverse combinable mechanical metamaterials and making conventional convergent strategies more efficient to various requests. Main
Calorimetric study of skutterudite (CoAs2.92) and heazlewoodite (Ni3S2)
Authors: Majzlan Juraj , Kiefer Stefan , Lilova Kristina , Subramani Tamilarasan , Navrotsky Alexandra , Tuhý Marek , Vymazalová Anna , Chareev Dmitriy A. , Dachs Edgar , Benisek Artur
Published: December 2021

Nickel and cobalt arsenides, sulfarsenides, and sulfides occur in many hydrothermal ore deposits, but their thermodynamic properties are not well known, in some cases not known at all. In this work, we determined a full set of thermodynamic properties for heazlewoodite and skutterudite. Both phases were synthesized in evacuated silica tubes at elevated temperatures, and electron microprobe analyses gave their compositions as Ni3S2 and CoAs2.92, respectively. Enthalpies of formation were measured by high-temperature oxide-melt solution calorimetry. The reference phases were pure elements, thus eliminating any systematic errors related to such phases. The enthalpies of formation at T = 298.15 K and P = 105 Pa are –216.0 ± 8.4(2σ) and –88.2 ± 6.1 kJ·mol−1 for Ni3S2 and CoAs2.92, respectively. Entropies were calculated from low-temperature heat capacity (CP) data from relaxation (PPMS) calorimetry and are 133.8 ± 1.6 and 106.4 ± 1.3 J·mol–1·K–1, respectively. The calculated Gibbs free energies of formation are –210.0 ± 8.4 and –79.9 ± 6.2 kJ·mol−1 for Ni3S2 and CoAs2.92, respectively. The PPMS CP data, together with a set of differential scanning calorimetry measurements, were used to derive CP polynomials up to 700 K with the Kieffer model based on previously published frequencies of acoustic and optic modes. Equilibrium constants for selected reactions with an aqueous phase were calculated up to 700 K. Geochemical modeling in these systems, however, should await until more reliable data for other phases from the system Co-Ni-As-S are available.
Aplikasi Pelawatan Jemaat Dengan Menggunakan Metode Haversine Berbasis Android
Authors: Kusnadi Abednego Rayhan , Purba Florensa Rosani Br
Published: December 2021

To visit congregation which is carried out by several members of the congregation who are members of the visiting workgroup accompanied by a pastor from the church visited. This activity is a form of expression of love, concern, and sympathy for the people being cared for. And it is hoped that through this visit, the congregation who is being cared for will get strength, comfort, and help in facing the struggles they are facing. Along with the development of current technology which can help the wider community to find out a person's location through a given address. By using the haversine method, visitors can make visits to the church's residence with a fairly short time and distance because the haversine method has the advantage of being able to calculate the distance and time using two lines on the earth, namely longitude and latitude. The making of this application is to produce an Android-based mobile application using Google Map to get the location of the congregation's residence which will be carried out by the visit to the Terang Hidup GKI congregation, where the visit is one of the service programs of the Terang Hidup GKI church.
Parametric Influence Study for Laser Cutting on Acrylic
Authors: Wangikar Sandeep S. , Dixit Manthan M , Wadekar Saurabh G , Nagtilak Harshal R , Hingmire Nitin D , Shinde Dipak P
Published: December 2021

Laser has been employed for producing the complex specimens very efficiently and magnificently. The use of acrylic components is becoming prevalent day by day. Hence it is required to study the various machining techniques for engraving or cutting of acrylic material. The one of the non-traditional machining processes which can be employed efficiently for machining of acrylic is CO2 laser machining. The parametric study of acrylic materials by using CO2 laser machining is discussed in this paper. The scanning speed and the laser power were considered as process parameters and the influence of these parameters is studied on the depth as response measure. The engraving depth is observed to be increasing with increase in power and noted to be decreasing with increase in the scanning speed.
Experimental Investigation of Evaporative Hybrid Water Cooler
Authors: Bandgar Swapnil S , Jagtap Suhas D
Published: December 2021

The water cooler is a device which cools and dispenses water which is used to provide easy access to drinking water. The water coolers which are currently available in the market are works on the concept of VCR (Vapour Compression Refrigeration) System. These water coolers consume high electric power almost 250-350W, these systems also have huge impacts on the ecosystem due to CFC and HCFC emissions. Best alternative for existing VCR based water cooler is the system of evaporative cooling with thermoelectric cooler having affordable cost and eco-friendly. Hybrid water cooler works on the principle of evaporative cooling and Thermoelectric cooling, which provides cold water, hot water and it works as an Air cooler also. Evaporative cooling works on concept of evaporation of water and rate of evaporation is totally depending on humidity of surrounded air. By using evaporative cooling obtain the temperature difference of 8-10°C. During the hot day, the temperature of water in the water tank would be 40°C, then the evaporative cooling alone will not be sufficient to cool the water to 22°C, which is ideal temperature of water for drinking purpose. So, thermoelectric module works on principle of Peltier effect which can produce the temperature difference across its surfaces on applying potential difference across its terminals. As the thermoelectric module produce the temperature difference up to 40°C across its surface, it can easily cool the water to 20°C. More than 60% energy could be obtained by this system in comparison with respect to existing VCR based cooler, so this system can be used as an eco- friendly and cost effective.
Development of Hybrid Electric Bicycle using Stirling Engine
Authors: Shete Yogesh S , Pawar S. A
Published: December 2021

In India, these days, the solicitation for electric bicycles continues expanding step by step. Be that as it may, as indicated by the office foundation and in contemplations of India's best electric bikes, it is nearly difficult to utilize such electric bicycles for long excursions till today. Likewise, such bicycles set aside an excess of effort to get completely energized. To limit these downsides, we will see an idea of the crossover bike utilizing the Stirling Engine in this paper. The fundamental explanation for choosing the Stirling motor is, it is eco-accommodating and doesn't need a particular warmth source as a fuel. In straight words, this idea has a place in the law of energy preservation. This paper includes the concept, functions, and testing of the developed model along with an explanation of various tests performed to calibrate the performance.
Electronic Based Solar Dryer
Authors: Nikhil Patil , Dipak Mane , Deshmukh Manoj J
Published: December 2021

Drought of fruits and vegetables is a promising food processing technology that increases shelf life of products for almost a year. It is a value of process that can save the losses of seasonal agriculture products. The Solar dryers can be used to carry food dehydration without on electricity. India is most of agriculture-dependent country. Fruits and vegetables are an basically part of human diet providing micronutrients, vitamins, enzymes, and minerals. Most fruits and vegetables it content moisture and water activity. This makes it is vulnerable to bug and other spoilages due to biochemical reactional, such as enzymatic activity, respiration, and senescence. Then, preventive measures are taken to lower water activity; drying or dehydration is we such one method. Drying is a process of mostly used removal of water from the food to in biochemical processes and microbial growth. Drying increases the service life of the product, so that it can be available during off season.
Image Processing: Methods, Techniques, Applications Review
Authors: Ghodake Yogesh Shankar , Bhosale Dipak V , Kulkarni Sushil S
Published: December 2021

Nowadays, image processing became very important especially in real-time where the results of real-time image processing failures can be severe; therefore, the study and research in methods of real-time image processing are of extreme significance. The main contribution of this paper is to provide an overview of the current state of real-time image processing research (Applications), the relevant techniques, and methods.
Single Phase Variable Voltage Generation using Keyboard & Microcontroller
Authors: Lambe Somnath M. , Karande Kailash J , Dhekane Arvind G
Published: December 2021

Normally a single phase voltage is varied by analog methods such as dimmer but we cannot get exact voltage by dimmer also. To achieve smart/exact voltage level VFD drives are used. To vary voltage by changing the firing angle of thyristor a variable ac voltage can be obtained. Thyristor conducts in both cycles of ac. If conduction angle is controlled by firing angle of thyristor. For half ac cycle firing angle changes from 0 degree to 180 degree according to that conduction angle changes. As conduction angle and firing angle are inversely proportional to each other. Means that if firing angle less then conduction angle is more and vice versa. A zero crossing detector circuit is used to know the zero point of ac. when zero crossing section gives output of logic 1 then from this point ac voltage starts to rise/fall. This is the reference point from that point to maximum 180 degree point firing angle can be controlled. In this way a variable output voltage is generated.
On-Line Signature Verification
Authors: Patil Swati M , Gaikwad Poonam V
Published: December 2021

In this paper, we are going to propose a new technique for On-Line signature based on global n local features. In general, shape of an on-line signature is used as a single discriminating feature. Sometimes shape of signature is used alone for verification purposes and sometimes it is used in combination with some other dynamic features such as velocity, pressure and entropy. In proposed system shape of signature is examined using Edge-Detection Algorithm (EDA), pressure points are calculated using Pressure Points Allocation using Clustering (PPAC). So the overall process can be thought as the process is signature examination based on shape and pressure points in combination with entropy and velocity and it performs verification on each partition separately. Finally, the signature is classified as genuine or a forgery.
Student Examination Portal
Authors: Kulkarni S. M , Awati M , Kadere R , Paricharak N , Babar T
Published: December 2021

Online Examination Portal may be a web portal (or) we will say an internet application helps the students where they will get their college subjects material, placement preparation material and they can access the notes and test. It’s also helpful for the staff because it provides the results automatically after the examination with accuracy. This examination contains the multiple MCQ test series, this helps students to offer the exam far away from distance and which may provide security, ease, and other beneficial features to the user. Recent references [1] should be included for showing previous work done and the importance of current work. This section should be succinct, with no subheadings unless unavoidable [2, 3]. State the objectives of the work and supply an adequate background associated with your work, avoiding an in-depth literature survey or a summary of the results.
Understanding the Structural Audit Building
Authors: Sutar Atul , Babar Anil
Published: December 2021

This paper examines many aspects of structural auditing, including visual examination, non-destructive testing, core sample, and testing. It also emphasises various building repairs and retrofitting procedures that should be employed after a structural audit. As the structure matures, it need frequent maintenance and inspection in order to avoid further damage. The health and performance of a building are dependent on its maintenance quality. In order to protect the structure from environmental effects, it should be monitored on a regular basis by a professional. As a result, a structure audit is performed to assess the overall health of the building. A structure audit is a preliminary technical survey performed on a structure to recommend repair solutions.
Experimental Analysis of Demolished Concrete by Using its Coarse Aggregate as Recycling Material
Authors: Pawar Sagar M , Babar Anil T
Published: December 2021

Concrete is most widely used in construction material all over the world in view of its compressive strength, Moulding ability, structural ability and economic consideration. Recycling of Demolished concrete aggregate means the process of collection and reusing it in their original form. Use recycled aggregate (RCA) in concrete is helpful for protection of environment and economic point of view. Recycled aggregate are the material for future, as it is used up to 20 % of replacement by natural aggregate available from quarries. This paper gives application of coarse aggregate from recycled demolished concrete when used in M20 mix proportion with different percentage of recycled aggregate replaced with natural one and its result analysed at 7,14, and 28 days of compressive strength.
Modification of Planetary Mixer with Strainer Arrangement
Authors: Chavan Mahesh , Kapase Dnyaneshwar , Parachande Manish , Hingmire Shambhu , Gund Mahesh , Autade R. S
Published: December 2021

The stirrer of conventional machine rotates in one direction only which creates a specific flow pattern within the fluids hence the particles tend to stay to the walls of container owing to the force instead of mixing thoroughly in mixture of paint, ultimately results into poor quality mixture of paints there by poor quality output of paint . In order to possess a through mixing of metal oxide powder it might be appropriate to possess a stirrer that rotates such rotates about own axis also revolves about another fixed axis which helps it reach all parts of the container. This ensures that turbulence required for thorough mixing is provided all over the container. It would be advantageous to vary pattern of flow, which avoids vortex formation, i.e. motion of particles in a spiral path. Also if a wiper is added that brings the particles adhering to walls of container back to main flow or mixing area, good quality mixture are going to be ensured. The planetary mixer with strainer may be a perfect solution that has all the above mentioned features. This machine involves a rotating stirrer that revolves about the fixed container axis also as incorporates an strainer that changes the flow pattern and also acts as a wiper. Machine has variable mixing speed feature at an equivalent time delivers heavy torque to the stirrer for proper mixing.
Natural Air Cooling System
Authors: Bhosale Praddyumn , Bhosale Ashutosh , Kulkarni Ajit , Jagtap Navnath , Karvekar Uday
Published: December 2021

Increase of indoor temperature compared with outdoor temperature is a major concern in modern house design. Occupants suffer from this uncomfortable condition because of overheating indoor temperature. Poor passive design causes heat to be trapped, which Influences the rise in indoor temperature. The upper part, which covers the area of the roof, is the most critical part of the house that is exposed to heat caused by high solar radiation and high emissivity levels. During day time, the roof accumulates heat, which increases the indoor temperature and affects the comfort level of the occupants. Our aim is to provide cooling effect by arrangement of electric fan and Copper pipe with minimum cost. Our second aim is to drop the room temperature by 6-8 Degree Celsius.
Curso Clínico y Perfil Neuropsicológico de un Caso de Trastorno Neurocognitivo Frontotemporal Mayor Variante Lingüística
Authors: Rico Velasco Gloria Andrea , Martínez González Carmen Patricia , Benavides López Gina Paola , Motta Artunduaga Maribel
Published: December 2021

El trastorno neurocognitivo frontotemporal es una enfermedad neurodegenerativa que incluye manifestacio- nes clínicas de subtipo comportamental y lingüística. La afasia progresiva primaria (APP) es un síndrome en el que aparecen alteraciones del lenguaje que comprende tres tipos de variantes: no fluente, semántica y logopénica. Este estudio describe la evolución clínica y las características neuropsicológicas de una mujer de 63 años que presenta un deterioro progresivo del lenguaje. Se evalúan las funciones de atención, memoria, lenguaje y funciones ejecutivas. La paciente obtuvo un bajo rendimiento en memoria, velocidad de procesamiento y funciones ejecutivas. Su lenguaje se caracteriza por presentar baja fluidez, agramatismo, parafasias verbales y dificultades en denominación. Se concluye que la paciente presenta características de la APP no fluente, que varía a través del tiempo y afecta su funcionamiento; características de un curso clínico de un trastorno neurocognitivo mayor posible debido a una degeneración del lóbulo frontotemporal.Palabras Clave: afasia progresiva primaria, neuropsicología, cognición, deterioro cognitivo, Demencia Frontotemporal
Identification of shallow cracks in rotating systems by utilizing convolutional neural networks and persistence spectrum under constant speed condition
Authors: Rezazadeh Nima , Ashory Mohammad-Reza , Fallahy Shila
Published: December 2021

The positive benefits of early faults detection in rotating systems have led scientists to develop automated methods. Although unbalancing is the most prevalent defect in rotor systems, this fault normally is accompanied by other defects such as crack. In this article, an effective self-acting procedure is addressed in identifying shallow cracks in rotor systems throughout the steady-state operation. To classify rotor systems suffering cracks with three various depths, firstly, healthy and cracked systems are modeled by employing the finite element method (FEM). In the following, systems' vibration signals are calculated in different situations numerically; for pre-processing stage, the persistence spectrum is implemented. Finally, by using a supervised convolutional neural network (CNN), rotor systems are classified by regarding the crack depths. The result of the testing step revealed that this hybrid method has rational capacity in distinguishing shallow cracks in steady-state operation where many other methods are somehow powerless.
A COMICIDADE DO MISERÁVEL EM ARIANO SUASSUNA
Authors: De Medeiros Elen
Published: December 2021

Propomos no artigo uma leitura da comicidade na obra de ArianoSuassuna, construída particularmente a partir da representação do miserável dosertão nordestino. Menos distante do que a tradição crítica supõe, a comicidadese aproxima do referencial trágico inerente à vida sofrida do sertanejo, pontofulcral do teatro de Suassuna, e é justamente a partir de uma ideia desobrevivência que o dramaturgo elabora seus principais dispositivos cômicos,marcando dessa forma a ‘prova dos nove’ da existência. Para tanto, duas obrasserão tomadas como exemplos e referências para o argumento do texto: O autoda compadecida, peça que consagrou o dramaturgo, e Farsa da boa preguiça,escrita em 1960 e encenada em 1961, pouco tempo depois do sucesso daprimeira
CORPO & LUGAR: REPENSANDO EXTENSÕES, CONSIDERANDO DISTENSÕES
Authors: Didonet Candice , Costa Thiago de Araújo
Published: December 2021

A prática extensiva que gera este artigo atualizou vivências do lugarocupado: o NAC - Núcleo de Arte Contemporânea da Universidade Federal daParaíba. O Curso de extensão “Corpo & Lugar” realizado com a abertura dalicenciatura em Dança na mesma instituição, provocou ações (per) formativasabordando sentidos de lugar na contemporaneidade sob o viés da pesquisaartística. Enfatizando contextos em João Pessoa com referenciais quetransitaram entre dança, artes visuais, performance e urbanismo, experimentosforam propostos para problematizar relações entre corpo(s) e lugar.
A cena Mitopoética: relações do consciente e do inconsciente no processo de criação
Authors: Almeida Saulo Vinicius , Éboli Luciana Morteo
Published: December 2021

Este trabalho analisa o conceito de Mitopoética no espetáculo Sebastian, uma obrade dança teatro que se constitui a partir do encontro do mito de São Sebastião coma história do ator-dançarino Sebastian Habib. Com base nos estudos do mito deMircea Eliade e do rito por Michel Mauss, discute as escolhas cênicas e o processode criação a partir do conceito de mito pessoal. Relaciona conceitos simbólicos deCarl Jung, elementos das memórias individual e coletiva, além das narrativasexpressas através da memória do corpo, nas percepções de Gaston Bachelard,Jerzy Grotowski e Antonin Artaud.
FREVO NA ESCOLA: UMA PESQUISA DE CORPO E DANÇA-EDUCAÇÃO
Authors: Cavalcante Lyane
Published: December 2021

Esse artigo tem como objetivo pesquisar e refletir sobre a prática das danças brasileiras, como o Frevo, nas escolas de Pernambuco, mais especificamente nas escolas públicas de Jaboatão dos Guararapes, enfocando os processos de ensino-aprendizagem, coreografia, reconhecimento social, ancestralidade, consciência corporal, ritmo e afetividade em que as aulas de dança proporcionam aos alunos da educação básica. A pesquisa descreve as experiências vividas em sala de aula, utilizando metodologias que envolvem a educação somática, com técnicas de Feldenkrais e a espontaneidade do Frevo, com técnicas do mestre Nascimento do Passo. Esses procedimentos são considerados construtores das práticas pedagógicas, coreográficas e tradicionais em que a dança está inserida, junto ao reconhecimento das dimensões corporais e espirituais do aluno.
O espírito do laboratório – Terceiro Teatro e seu legado
Authors: Jacome Alice
Published: December 2021

O presente artigo é uma transcrição do seminário apresentado por dois pesquisadores ingleses no primeiro Festival NTL - Nordisk Teaterlaboratorium, intitulado de "The Laboratory Spirit" (O Espírito do Laboratório). O festival, ocorrido entre os dias 30 de Janeiro e 3 de Fevereiro de 2019 no Odin Teatret em Holstebro, Dinamarca, reuniu jovens artistas e pesquisadores de várias partes do mundo, em busca de uma possível resposta em relação ao laboratório teatral : "O que é esse espírito do laboratório que reúne grupos do mundo inteiro?", "Qual a sua importância nos dias atuais?". Ao longo do festival, os participantes foram questionados à partir de 8 oficinas com diversos artistas e vários tipos de treinamento físico; ao se colocarem em posição de público em 23 apresentações teatrais; e no último dia do festival, à partir do simpósio transcrito nesse presente documento. O seminário começa com uma pequena fala de Julia Varley, introduzindo os dois pesquisadores ao universo do Odin. Então, os dois narram suas trajetórias e mesclam as teorias do terceiro teatro com o que foi visto e vivido nos cinco dias do festival.
A projeção vocal no teatro-estudo e tendências
Authors: Santos Marcos
Published: December 2021

O presente trabalho é um breve estudo de investigação sobre a projeção vocal nos dias de hoje nos jovens atores. Para servir de base neste estudo foram utilizados como ferramentas: um artigo publicado no jornal The Guardian, um método utilizado numa masterclasse com Cathleen McCarron, especialista em voz no Royal Shakespear Theatre, e a avaliação de uma prova dos alunos do departamento de artes cénicas da Universidade de Évora em Portugal. Os resultados foram supreendentes quanto à eficácia do método aplicado, não só a nível da projeção de voz mas também da compreensão do texto, e também esclarecedores do quoão descurada é muitas vezes a projeção vocal.
A emergência da escola
Authors: Vieira Arthur Cassio de Oliveira
Published: December 2021

Resenha de GONDRA, José G. (2018). A emergência da escola. São Paulo, SP: Cortez.
A presença/ausência da produção marxiana e de Manacorda nos currículos de pedagogia das universidades federais
Authors: Gomes Marco Antonio de Oliveira
Published: December 2021

Este artigo objetiva analisar a presença e ausência dos textos de Marx e Manacorda nos cursos de pedagogia de universidades federais. Assim, procura desvelar as orientações epistemológicas presentes na área de fundamentos da educação. Para realização do trabalho foram analisados os projetos político pedagógicos e a bibliografia disponibilizadas nos endereços eletrônicos das instituições. Tendo como princípio norteador o referencial teórico marxista, foram utilizados os seguintes autores: Gramsci (1982), Manacorda (1996, 2007), Marx (1984, 2007), Frigotto (2003), entre outros. A ausência de uma epistemologia alicerçada no materialismo histórico e dialético explica-se pela hegemonia material da burguesia que se traduz em um modelo de formação de professores que esvazia o conhecimento.
Ensino Profissional na nova capital mineira (1909-1927)
Authors: Ribeiro Betânia de Oliveira Laterza , Silva Elizabeth Farias da , Araujo José Carlos Souza , Bao Carlos Eduardo
Published: December 2021

A pesquisa teve como objetivo compreender a possível relação entre secularização, Estado e Ensino Profissional. No procedimento metodológico, procurou articular dialeticamente as dimensões local, estadual e nacional a respeito do ensino profissional. As fontes incluíram jornais, legislação educacional e mensagens de governadores. A análise e resultados sinalizam que a religiosização da vida terrena engendrou táticas eficazes para se contrapor à estratégia do poder terreno que se pensava laico. O Estado estabeleceu um decreto que propôs mudar a roda da fortuna e, mesmo mudar o destino dos desgraçados na terra. Está em processo a secularização, uma referência cultural para compreender a educação, pobreza, marginalidade e trabalho a partir do mundo do trabalho.
Educação Eugênica
Authors: Bonfim Paulo Ricardo
Published: December 2021

No estudo da relação entre Eugenia e Educação, na história da educação brasileira, a referência ao médico Renato Kehl logo se impõe pelos esforços empenhados em difundir a ciência eugênica, inclusive, entre educadores e escolares. No Brasil, a eugenia comportou variações significativas em relação às formulações em avanço em outras latitudes, amalgamando-se, por aqui, às discussões sobre educação, higiene e saneamento. O estudo avaliou propostas e iniciativas de Kehl para a educação, principalmente com base em suas publicações, com destaque para os manuais escolares, entre as décadas de 1910 e 1930. A análise de sua trajetória, realizações e recomendações contribuem para uma compreensão mais acurada das influências e articulações na conformação de propostas para a educação no período.
História da formação de professores para o Ensino Primário:
Authors: Sousa Joilson Silva de , Jeronimo Maria Keila
Published: December 2021

Resenha: Nascimento, Francinaide de Lima Silva. (2018). A Escola Normal de Natal (Rio Grande do Norte, 1908-1971). Natal, Editoraifrn.
S16020 Pyridocarbazole Derivatives Display High Activity to Lung Cancer Cells
Authors: Chabowska Gabriela , Moreira Helena , Tylińska Beata , Barg Ewa
Published: December 2021

Background:

Despite the dynamic development of medicine, globally cancer diseases remain the second
leading cause of death. Therefore, there is a strong necessity to improve chemotherapy regimens and search for new
anticancer agents. Pyridocarbazoles are compounds with confirmed antitumor properties based on multimodal mechanisms,
i.e. DNA intercalation and topoisomerase II-DNA complex inhibition. One of them, S16020, displayed a wide
spectrum of activity.

Objective:

The aim of the study was to investigate the antitumor potency of six S16020 derivatives, synthesized according
to the SAR (structure-activity relationship) method.

Methods:

The biological evaluation included influence on cancer cell viability, proliferation, and migration, as well as
P-glycoprotein activity. NHDF, A549, MCF-7, LoVo, and LoVo/DX cell lines were used in the study.

Results:

All derivatives displayed low toxicity to normal (NHDF) cells at 1 and 2 μM (≤ 20% of cell growth inhibition).
The highest reduction in cell viability was noted in A549 cells, which was accompanied by significant disruption
of cells proliferation and motility. Compound 1 exhibited the strongest cytotoxic, antiproliferative, and antimigratory
effects, higher than the reference olivacine. A significant reduction in P-glycoprotein activity was found for derivatives
6 and 1.

Conclusion:

S16020 derivatives could be considered as potential candidates for new anticancer drugs.
Antihyperglycemic Activity of Aqueous Extract of Euphorbia guyoniana in
Streptozotocin-Induced Diabetic Rats
Authors: Amssayef Ayoub , Azzaoui Bouchra , Bouadid Ismail , Eddouks Mohamed
Published: December 2021

Aims:

This work assessed the antihyperglycemic effect of Euphorbia guyoniana.

Background:

Euphorbia guyoniana (Boss. and Reut.) is widely used in traditional medicine.

Objective:

This study was designed to confirm this traditional use by assessing its antihyperglycemic
capacity in vivo.

Methods:

The effect of the aqueous extract of Euphorbia guyoniana (Boss. and Reut.) (60 mg/kg)
on glycemia in both normal and diabetic rats was evaluated. The glycogen content in the liver and
skeletal muscles (extensor digitorum longus and soleus) was measured. Furthermore, liver histopathological
analysis was performed.

Results:

The findings showed that Euphorbia guyoniana (Boss. and Reut.) exhibited a significant
decrease in glycaemia in diabetic rats (from 20±2 mmol/l to 5.5 mmol/l after 6 hours of oral administration;
p<0.0001 and from 20±2 mmol/l to 4.5 mmol/l after 7 days of once-daily repeated oral administration
of the aqueous Euphorbia guyoniana extract; p<0.0001). In addition, the extract increased
the glycogen content in the liver (41±4 mg/g versus 70±5 mg/g in normal and diabetic rats
respectively) and extensor digitorum longus (39±4 mg/g versus 60±1 mg/g in normal and diabetic
rats, respectively), and partially restored corporal weight in diabetic rats. Furthermore, this aqueous
extract has been shown to suppress hyperglycemia induced by glucose load in treated diabetic rats.
Additionally, hepatic histology in diabetic rats has been improved. This plant revealed the presence
of several phytochemical constituents and possessed antioxidant activity.

Conclusion:

The current study evidenced that Euphorbia guyoniana (Boss. and Reut.) has a beneficial
effect on improving hyperglycemia and glycogen depletion in the diabetic state.
Association between Food Intake and Overweight in Children Assisted by Primary Care
Authors: Lima Erivelton Sousa , Brandão Amanda de Castro Amorim Serpa , Gomes Junior Antonio Luiz , Moura Luana kelle Batista , Mesquita Gerardo Vasconcelos , da Silva Oliveira Adélia Dalva , Hartz Zulmira , Ramos Carmen Viana
Published: December 2021

Background:

The child feed in the first two years of life is of fundamental importance for a healthy growth and development.

Aims:

To verify the association between food consumption indicators and overweight in children under the age of two, followed up by primary care health professionals.

Methods:

A cross-sectional study was conducted on 232 children assisted by primary care. A structured questionnaire was used with questions on sociodemographic data of mothers or guardians and food intake and anthropometric data of children. The analysis of the association between excess weight and food intake indicators was performed using the Pearson’s chi-square test (χ2) and Fisher’s exact test (f ˂ 5).

Results:

Regarding food intake in children under 6 months of age, 35.1% of the children were exclusively breastfed. Among children at the age of 6 to 23 months: 66.3% were on continued breastfeeding; 16.7% consumed adequate foods at the age of 6 to 8 months; 90.4% consumed foods that belonged to the six food groups; 76.3% consumed food at the minimum frequency and with adequate consistency; 88.9% consumed iron-rich and vitamin A-rich foods, and 59.3% consumed ultra-processed foods. Regarding nutritional status, 24.5% of the children were overweight.

Conclusion:

There was no statistically significant association between overweight and food consumption indicators among the surveyed children. However, exclusive breastfeeding was below the recommended level, a low percentage of the introduction of complementary foods at the appropriate age and high consumption of ultra-processed foods reveal the need to improve the assistance provided by primary care to this group.
Experiences of Family Members of Children with Autism
Authors: Maria Sousa de Carvalho Claudia , Caminha Morais Islana , da Silva Borges Juliana , Clara Araújo Oliveira Maria , Eduarda Sousa de Carvalho Ana , Cláudia Miranda Amorim Fernanda , Dalva da Silva Oliveira Adélia , Macêdo Magalhães Juliana , Angela Lo Schiavo Sarisawa Emilia , Sávia de Souza Araújo Adriana
Published: December 2021

Introduction:

Autism spectrum disorder is characterized by the change in the behavior-interaction-communication, with different levels of impairment.

Objectives:

This study aims to describe the experiences of family members of children with autism and discuss strategies to improve the quality of life of family members.

Methods:

A descriptive, exploratory study with a qualitative approach was carried out in a self-help association for autism, located in the city of Teresina/PI, Brazil. Data collection took place in September and October 2019 through the application of a semi-structured interview. Eighteen (18) family members of children with autism in the Association of Friends of Autistic Individuals (AMA) participated in the study. Bardin’s content analysis was the technique used for data analysis.

Results:

The results showed experiences of negative feelings on the part of family members who lived with autistic children, such as frustration and pain, but also positive feelings of affection and dedication and state of neutrality. The daily life of family members involved the experience of difficulties due to the care of the autistic children, in addition to the lack of information regarding different cases of autism. Therefore, it is necessary to include family members and children in support networks with the objective of making them a part of society with the help of the multidisciplinary team.

Conclusion:

The present research showed that the experiences of family members of children with autism are difficult at first, but with daily learning and interaction, they become rewarding. The study also reinforces the importance of team in the care of autistic children and highlighted the relevance of improving the family’s quality of life, which can also reflect on the quality of care of that individual.
Measurement of Hemodynamic Parameters and Antidepressant Activity
in Hypertensive Rats Following Two Weeks Consumption of Acacia Tortilis
Leaves Extract
Authors: Serafi Abdulhalim , Azmat Aisha , Ahmed Muhammad , Bafail Mohammed , Hussain Zahir
Published: December 2021

Background:

Depression is common in hypertensive patients, and monotherapy may
contribute to controlling depression in hypertensive patients and improving socioeconomic outcomes.
Previous studies have shown that Acacia tortilis possesses hypotensive activity.

Objectives:

The present study was planned to evaluate the hemodynamic activity and antidepressant
effects of an ethanolic extract of Acacia tortilis leaves (ATEL) in salt-induced hypertensive
rats.

Methods:

Sprague-Dawley rats were divided into 5 groups for experiments. The rats received respective
treatment for 15 days: G1: Control (C); G2: hypertensive control (HC: high dietary salt,
4% 10ml/kg); G3-5: HC+ ATEL (50, 100, 150mg/kg respectively). Cardiac hemodynamics (mean
arterial blood pressure: MAP and heart rate: HR) were measured in the anaesthetized rats by an invasive
method. For this method, one carotid artery was catheterized, a pressure catheter (pressure-
volume Millar microtip catheter connected to the Mikro-Tip Pressure-Volume System from
Ultra Foundation Systems, PowerLab) was inserted, and the blood pressure (MAP in mm Hg) and
HR (beats/min) were monitored continuously during the experiment. For the neuropharmacological
studies, antidepressant activity was assessed by a forced swim test on the 15th day.

Results:

A dose-dependent significant increase in mobility time was observed in rats (G3-5) treated
with HC + different doses of ATEL (p < 0.05). However, the mobility time was significantly reduced
by HC (G2) treatment compared to the control (p< 0.05). The hypertensive control (high dietary
salt: HC) group showed a significant increase in systolic blood pressure (SP), diastolic blood
pressure (DP), MAP and HR (p<0.05) compared to the control (G1) group. At all doses (50, 100,
and 150 mg/kg), MAP and HR were found to decrease significantly (p<0.05) compared to the values
in the HC (G2) group. Further analysis revealed an improvement in heart rate variability
(HRV) in ATEL-treated hypertensive rats.

Conclusion:

The present research suggests that increased dietary salt intake not only increases
blood pressure significantly but also increases depression. ATEL contains some efficacious constituents,
such as N, N-dimethyltryptamine (DMT: a 5-HT1A agonist), with predominant antidepressant
and antihypertensive activity. Hence, ATEL appears to be a valuable plant extract that can
be useful, at least as an adjunct, for therapy in patients who suffer from both depression and hypertension.
Olímpia era tão alta que a sua cabeça desaparecia entre as nuvens a expressão de grau na obra A girafa que comia estrelas de José Eduardo Agualusa
Authors: Oliveira Inês
Published: December 2021

The main objective of this article is to reflect on the notion of degree and the structures that allow its expression, highlighting its importance for reading comprehension and the development of (meta)linguistic and communicative skills of the student. So, first, there will be a brief review of the expression of degree and reading comprehension. In order to frame the theme and the contents at the teaching level, an analysis of the normative documents that guide the teaching of Portuguese in the Primary School and 2nd Cycles of Basic Education will be presented, showing how the expression of degree arises proposal for approach. In this sense, the different guiding documents for the teaching of Portuguese will be analyzed, by years of schooling, identifying the domains in which the content appears, recording its direct and indirect occurrences. This content is mainly proposed in the domain of grammar. Later, the work A girafa que comia estrelas, of José Eduardo Agualusa, will be explored, showing how the degree’s expression mechanisms help in the construction of the meanings of the text. Finally, there will be a brief reflection on the need for scientific and solid knowledge about the structure and functioning of language in order to access the meaning of the text and outline relevant and consequential pedagogical activities