bluuebunny/crossref_metadata_2025 huggingface dataset:
Institutional Resource Management Practices: A Case Study of CPSU Reservation
Authors: Dagunan Mary Ann S
Published: November 2019

The study assessed the existing land resources, management practices and resource utilization of the Central Philippines State University reservation in Kabankalan City, Negros Occidental. It is a descriptive research that employed line-plot method for vegetation analysis; point counts, transect walk, cruising method, and mist netting for faunal assessment; secondary data analysis for processing of geospatial information and socio-economic profiles; and, interviews and focused group discussions for sourcing data on land management practices and resource utilization. Significant findings showed that the institution has a very vast area of 4,653 hectares land reservation. but the biological and physical resources therein are under threat because of the presence of settlers who compete for and misuse the land. As a developing institution, the university is expected to need more land area for expansion of physical plant facilities and enterprise development. It is therefore apparent that the university must efficiently use and manage the valuable resources granted by the government in order to become a self-sustaining institution that consistently provides quality instruction, research, extension and production and fosters growth and sustainable development within an ecologically balanced environment and an empowered community in the reservation.
Varietal Trial of Traditional Upland Rice (Oryza sativa L.) Varieties Collected in the Province of Negros Occidental
Authors: Lumba Angelie L , Posadas Mae Flor G
Published: November 2019

Thirteen traditional upland rice varieties (Kadidit Pilit, Red 64, Masipag 9, Masipag 15, Dinorado, Mindoro, Camuros, Masipag 22, Palawan, Suleg, Biday, Pilit , Pilit Talacdan) were evaluated in Randomized Complete Block Design (RCBD) in three replicates at the experimental area of Central Philippines State University (CPSU), Kabankalan City, Negros Occidental from November 2012 - April 2013. The parameters compared were their agronomic data on growth and yield, including grain characteristics. These data were processed using the one-way Analysis of Variance (ANOVA) with the Statistical Tool for Agricultural Research (STAR) (Version 2.0.1) while Duncan’s Multiple Range Test (DMRT) were used to compare significant treatment means at 1% level. The upland rice varieties showed significant variation in growth, yield showed distinct grain characteristics. Biday variety was the tallest, produced longer and wider leaves, and bore the longest panicle. Mindoro and Masipag 22 produced the most number of tillers. Pilit talacdan had the biggest culm, produced the heaviest panicle, with the highest number of filled grains per panicle. Pilit variety gave the heaviest weight of 1,000 grains. The grain features were also found to be distinct in each variety. The yield significantly varied among the upland rice varieties. Pilit and Pilit Talacdan gave the highest yield among the varieties grown at CPSU condition. The performing varieties would be used for upland rice improvement and breeding program and for further verification in the farmer’s field.
Theoretical and practical aspects of the implementation of the principles of closed-cycle economics
Authors: Титов Виктор , Titov Viktor , Морозов Олег , Morozov Oleg
Published: November 2019

The article deals with the relationship between the categories of sus­tainable development, resource theory, resource Economics, closed-cycle Economics. The emphasis is placed on the content of the resource theory, as according to the authors, the provisions of this theory are the link between the sustainable development of the economy and the closed-cycle economy model. Statistical data on the Nizhny Novgorod region, reflecting the de­velopment of the waste management system, which is an element of the closed-cycle economy, are considered. Concludes that the significance of the transition from a resource economy to a closed-loop model.
Tasks of economic analysis, used in the process of organizing the local government
Authors: Хмыз Александр , Hmyz Aleksandr
Published: November 2019

The relevance of the studied topic is indicated by the fact that the eco­nomic analysis of economic activity is applied not only at the level of a single enterprise, but also at the level of local governments and the state as a whole. In this case, economic analysis is used to make the most correct deci­sions in relation to the direction of the use of budgetary funds, eliminate the causes of shortage of funds in a particular subject of the Russian Federation, increase the importance of goods exported from the region to other subjects of the Russian Federation and other countries. In order for the above-men­tioned goals to be fully achieved, it is necessary to correctly define the tasks of economic analysis, solved by local authorities.
APPLICATION OF INNOVATIONS SOCIOLOGY TOOLS TO THE INNOVATIVE DEVELOPMENT OF ENTREPRENEURSHIP STRUCTURES
Authors:   Doctor of Economics, Chief Researcher  Center for the Study of Public Opinion ", Trostyansky D. V. ,   IJtimoiy Fikr", Aydinova М. А. ,   PhD in Economics, Senior Researcher  Center for the Study of Public Opinion "Ijtimoiy Fikr"
Published: November 2019

The article reveals the specifics and the scientific and practical potential of social innovation mechanisms, the advantages of the tools of sociology of innovations, as compared with economic analysis to ensure the innovative development of business structures. A qualitative assessment of the state of the business environment of Uzbekistan as the main factor for the sustainable development of business entities and their susceptibility to innovation is given.
STEM EDUCATION FOR PRE-SCHOOL CHILDREN
Authors:   Chief Specialist  Ministry of Innovative Development of the Republic of Uzbekistan, Gainulina K. T.
Published: November 2019

The article is devoted to studying the experience of developed countries in the sphere of innovative method of education STEM for pre-school children. The main objective of the analysis is to critically evaluate opportunities and feasibility of adaptation of STEM in pre-school educational institutions of the Republic of Uzbekistan, as well as identify the effectiveness of the program
GENETIC STRUCTURATION OF SITOPHILUS ZEAMAIS SUBSERVIENT TO MILLET ACCORDING TO AGRO ECOLOGICAL ZONES OF SENEGAL (WEST AFRICA)
Authors: SARR Ngagne Demba , DIOME Toffène , THIAW Cheikh , SEMBENE Mbacké
Published: November 2019

In Senegal, millet is the most exploited cereal and the second most one consumed after rice. It is cultivated in most agroecological zones whose more or less arid climatic characteristics favor the development of several insect pests, among which Sitophilus Zeamais, a beetle of the Curculionidae. This insect causes a lot of losses of millet stocks, mainly in four agro-ecological zones: NBA , SBA , SOHC and BMC .
Our study aims to highlight a possible genetic structuring of Sitophilus Zeamais subservient to millet according to these agroecological zones.
The advantage of the existence of a genetic differentiation between agroecological zones is to be able to detect after the degree of genetic homogeneity of each one of them and consequently their impacts on the survival or the extinction of the insect, because the genetic diversity of populations influences their adaptive potentials.
To achieve this goal, we sampled Sitophilus Zeamais insects subservient to millet in each agroecological zone. 43 individuals were harvested in total.
The exploitation of the sequences of the cytochrome b gene corresponding to these individuals has highlighted a genetic structuration of Sitophilus Zeamais subservient to millet according to the 4 agroecological zones, attested by the values of genetic distance, Fst ones and corroborated by the results of the test. AMOVA.
KEYWORDS : Sitophilus Zeamais, cytochrome b, millet, genetic structuring.
Okul Öncesi Eğitime Devam Eden Çocukların Trafik Farkındalığının Bazı Değişkenler Açısından İncelenmesi (Şanlıurfa Hilvan Örneği)
Authors: Çelik Fatma Tuğçe , Bekir Hatice , Aral Neriman , Aydın Remzi
Published: November 2019

Araştırmada, okul öncesi eğitime devam eden
beş yaş çocukların trafik farkındalığını belirlemek, trafik farkındalığında cinsiyet, devam edilen kurum türü ve anne baba öğrenim durumunun etkili olup
olmadığını incelemek amaçlanmıştır. Tarama modelinde olan bu çalışmaya Urfa ili Hilvan ilçesinde okul öncesi dönem
çocuklarına yönelik olarak gençlik merkezi bünyesinde açılan akıl oyunları-zeka
kulübüne ve eğlence merkezine katılan 56’sı anaokuluna, 44’ü ise anasınıfına
devam eden beş yaş, çalışmaya gönüllü katılan ve normal gelişim gösteren toplam
100 çocuk dahil edilmiştir. Çalışmada çocuk ve ailesi hakkında bilgi
edinebilmek amacıyla Genel Bilgi Formu ile çocukların trafik farkındalıklarını
belirlemek amacıyla Aral vd.  (2016)
tarafından geliştirilen  “Trafik Bilinci
Değerlendirme Ölçeği-Çocuk Formu” kullanılmıştır. Verilerin toplanma sürecinde
çocuklar ayrı ayrı bir sınıfa alınmış ve veri toplama süresi her çocuk için
ortalama 15-20 dakika sürmüştür. Verilerin analizinde  %95 güven düzeyi ile çalışılmış ve verilerin
normal dağılım gösterip göstermediği analiz edilmiştir. Analizler sonucunda
veriler normal dağılım göstermediği için parametrik olmayan test tekniklerinden
Mann Whitney U ve Kruskal Wallis testleri kullanılmıştır Farklılığa yönelik
yapılan analizlerde (k>2), anlamlı farklılık bulunan gruplardaki
farklılaşmanın nereden kaynaklandığının belirlenmesinde Mann Whitney U testi
kullanılmıştır. Araştırma sonucunda çocukların
trafik farkındalıklarının orta düzeyde olduğu belirlenmiştir. Trafik Bilinci
Değerlendirme Ölçeğinden elde edilen puan ortalamasının baba öğrenim
durumuna göre anlamlı düzeyde farklı olduğu (X2=14,042; p<0,05) saptanmıştır. Bu farklılığın hangi gruplardan
kaynaklandığını belirlemek üzere yapılan “Mann Whitney-U” testi sonucunda üniversite mezunu
olan babaların çocuklarının trafik konusundaki farkındalıklarının okuma yazma
bilmeyen, ilkokul, ortaokul ve lise mezunu olan babaların çocuklarına göre daha
yüksek olduğu görülmüştür. Ayrıca okuma yazma bilmeyen babaların çocuklarının
trafik konusundaki farkındalıklarının ortaokul ve lise mezunu olan babaların
çocuklarına göre daha düşük olduğu görülmüştür. Çocukların cinsiyet,
okul öncesi eğitime
devam ettikleri kurum türü, anne öğrenim düzeyinin Trafik Bilinci
Değerlendirme Ölçeği puan ortalamalarında istatistiksel olarak anlamlı düzeyde
bir farklılık oluşturmadığı saptanmıştır.
Peran Pusat Informasi Dan Konseling (PIK-KRR) Terhadap Perilaku Seksual Berisiko Pada Smpn Terpilih Di Jakarta Selatan Tahun 2016
Authors: Andriani Putri
Published: November 2019

Sexuality among teenagers needs to be directed seriusly into behavior that does not bring any risks. One of the intervention given to adolescent reproductive health concerning sexuality is by providing reproductive education to schools. This was a comparative study using a cross sectional method in two junior high school which had and did not have the Information and Counseling Center of Reproductive Health (PIK-KRR) amounted to 136 samples. Data was analyzed with Mann Whitney test. This  research  showed  that  there  was  a  significant  difference  in  attitute  in  risky  sexual  behaviour (p=0.000) and knowledge level of health reproduction (p=0.000) between school which had and did not have PIK-KRR. In bivariate analysis, there was a significant difference in gender to risky sexual activity, porn media access to risky sexual activity, gender to attitude of risky sexual behaviour, religiousity to attitude, attitude to porn media access, attitude to peer affect (p=0.004) and religiousity to knowledge level of health reproduction. This study concluded that the level of knowledge had a significant relationship with risky sexual behavior among adolescents at the two study sites.
BREASTFEEDING PRACTICES [POSITIONING, ATTACHMENT/LATCH- ON AND EFFECTIVE SUCKLING
Authors: Rinata Evi , Sari Putri Anjar
Published: November 2019

The scope of the exclusive breastfeeding in Indonesia based on basic health research (Riskesdas) in 2013 reached 30,2%, still far from target nationally by 80%. Based on research conducted in developing countries showed that infants were not breastfed would have a risk 6–10 times higher died in the first few months of life. This will impact the Infant Mortality Rate (IMR). The purpose of this research is to know the relation mother’s age, parity, education, maternal occupation, breast diseases, gestation and birth weight to breastfeeding practices. This research uses analytic cross sectional design with the entire population of parturition and the maternal mother who came to breastfeeding her infant at Sidoarjo General Hospital in 14-27 July 2015. Using primary data with interviews and observations and also secondary data. Using the sampling probability sampling, simple random sampling technique. The number of samples as much as 45 nursing mothers from 51 populations. The results of the test statistic chi-square showed no relationship to maternal age with position (p=0.929) and bonding (p=0.569). There is no relationship to parity with position (p=0.122), but found a significant relationship between bonding with parity (P=0.024). Education is not associated with the position(p=0.806) and bonding (p=0.595). No relation to maternal occupation with position (p=0.395) and bonding (p=0.329). Breast disease significantly shows there is a relationship with position (p=0.009) and bonding (p=0.000). Gestational there is no relationship with bonding (p=0.767) and effectiveness of contact (p=0.500). There is no relationship of weight born by bonding (p=0.754) and effectiveness of contact (p=0.519). The conclusion of the research that is no relationship between maternal age, education, maternal occupation, gestation and birth weight with breastfeeding practices. There is a relationship between parity and breast diseases with breastfeeding practices. Keyword : , , ,
Keefektifan Alat Bantu Ajar Low-Cost Pada Pembelajaran Klinis AKDR
Authors: Tombokan Sandra G.J.
Published: November 2019

Teaching aids in clinical learning in midwifery education are essential. However, not all tools manufactured and sold meet the 'low-cost' quality standard. The IUD insertion and disposal aids tool has been created by JM Metha by modifying the already-sold-out tools for the purposes of the previously mentioned clinical learning. Therefore, this study is intended to prove that the 'Metha' tool meets three criteria of 'realistic, durable, and inexpensive' teaching aids in addition to being 'safe' because they are made of non-hazardous fabrics.
Faktor-Faktor yang Berhubungan dengan Kadar Hemoglobin pada Siswa SMP
Authors: Aisyah Aisyah
Published: November 2019

This research intent on known factors that associated with hemoglobin rate in junior high school student at bekasi whether there is associated beetwen age, gender, breakfast habbit, ferosus tablet consuption, smoking cigarettes, knowladge about anemia, maternal education, job status, parents income and infection related with hemoglobin rate. This research used Quantitative methode with cross sectional design. Research population are students in SMP B at Bekasi year of 2015, and total sample of this research choosen by the inclusion criteria are 171 respondents Analyzis date use chisquare and multiple logistic regression. This research shows that haemoglobin rate < 12gr/100 ml in female student and < 13 gr/ 100 ml in male student are 16,5%. Bivariate analysis shows that there are significant difference in ferrosus tablet comsuption (P=0,001), knowledge rate about anemia  (P=0,001), maternal education (P=0,009), Parents income (P=0,034), and infection status (P=0,040). Multivariate analysis shows that the most dominan factor are ferrosus tablet consuption (OR = 0,018 dan P=0,001) and knowladge rate about anemia (7,253 dan p-value 0,001).
Pengaruh Pemberian Buah Pisang Mas Terhadap Peningkatan Kadar Hb Pada Ibu Hamil Trimester III
Authors: Safitri Elsa Kumala , Mualimah Miftahul , Riska Herliana
Published: November 2019

Hemoglobin is a protein-rich substance bezi, Have affinity (power team) against oxygen and with oxygen it forms a oxihemoglobin in red blood cells. The goal in this research is to know the influence of banana fruit mas to increased hemoglobin on pregnant women trimester III in BPM Ny "B" Ngasem Regency Kediri Year 2017. In this research method using alphabets experiment and approach Pre alphabets experiment with Purposive Sampling. This research was conducted in BPM Ny "B" Ngasem Regency Kediri Year 2017. Instruments in use are sheets of observation, data analysis with the iji Wlcoxon Signed Rank. Results of research of banana fruit mas on pregnant women this trimester III that the magnitude of the value of ρ is less than the value of 0.000 α = 0.05 (0.000 < 0.05) so that H0 is rejected and the H1 is accepted means there is influence of hemoglobin levels before and after the given bananas mas against peningktan the levels of haemoglobin in pregnant women Trimester III in BPM Ny. " B “ Ngasem Regency Kediri year 2017. With this expected to consume fruit banana mas on pregnant women may help lower III trimester anemia with practical.
Pengaruh Pendidikan Kesehatan Remaja Melalui Media Video Terhadap Pengetahuan Siswa Tentang Dampak Seks Bebas
Authors: Siwi Chelsea Titis Mentari , Utami J. Nugrahaningtyas W. , Astuti Tutik
Published: November 2019

Nowadays, many teenagers are faced with various challenges related to sexuality, such as the case of adolescent pregnancy enhancement, and high levels of sexually transmitted diseases (IMS) such as HIV/AIDS. This is hard for the teenagers to avoid because of several factors, such as the development of a child who is looking for a personal identity and always wants to try new things in their environment. The purpose of this research is to know the influence of adolescents ' health education through video media to change students ' knowledge of adolescent free sex impact in one of the high schools in Jogyakarta. This type of research is pre-experimented with a research plan of one group Pretests postest. The number of respondents was 97 students using total sampling technique. Bivariate analysis of the statistics of Wilcoxon, with an error rate of 5% (0.05). Most of the knowledge of respondents was pre Test 69 (71.1%), and post Test 61 (92.4%). The average level of knowledge of respondents pre test mean = 77.53 and the knowledge level respondent post test mean = 89.77 with the significance value of knowledge variable 0.000 (P value < 0.05) (α). There is a health education influence through video media to student knowledge about the impact of adolescent free sex age.
MEKANISME ANGGARAN BIAYA PEMASARAN TERHADAP TARGET PENJUALAN
Authors: Tanjung Mansur
Published: November 2019

ABSTRAK

Penulis bertujuan untuk mengetahui kegiatan pemasaran yang terarah dengan baik penting bagi perusahaan agar dapat meningkatkan dan mempertahankan posisi produknya di pasar. Dengan demikian perusahaan harus memperhatikan, mengendalian biaya-biaya yang dikeluarkan untuk pemasaran dan biaya pemasaran ini harus direncanakan atau diperhitungkan dengan cermat untuk pembuatan anggaran.

Metode penelitian yang digunakan dalam penelitian ini adalah penelitian korelasional. Rumus yang digunakan dalam perhitungan penelitian ini adalah rumus product moment. Dari hasil perhitungan data anggaran biaya pemasaran terhadap target penjualan dari tahun 2011 sampai dengan 2015. Peranan Anggaran biaya pemasaran  sebagai pedoman (sebagai alat perencanaan, alat koordinasi, dan alat pengendalian) sudah berfungsi dengan sangat baik. Terbukti dengan tercapainya target penjualan yang telah ditetapkan perusahaan.
Efektivitas Fungsi Pengawasan Dalam Pendistribusian Raskin Di Desa Tetehosi I Kecamatan Gunungsitoli Idanoi
Authors: Bate'e Maria Magdalena , Gea Nov Elhan
Published: November 2019

Pengawasan pada dasarnya diarahkan sepenuhnya untuk menghindari adanya kemungkinan penyelewengan atau penyimpangan atas tujuan yang akan dicapai. Pengawasan adalah proses penentuan apa yang akan dicapai sesuai dengan standar yang berlaku, apa yang sedang dilakukan, bagaimana menilai pelaksanaannya, dan bilamana perlu mengambil tindakan yang korektif. Tujuan dari penelitian ini untuk mengetahui efektivitas fungsi pengawasan pendistribusian Raskin di Desa Tetehosi I Kecamatan Gunungsitoli. Ditinjau dari karakteristik masalah maka dalam penelitian ini menggunakan jenis penelitian Deskriptif dengan pendekatan kualitatif. Dalam penelitian ini yang menjadi populasinya adalah seluruh masyarakat Desa Tetehosi I Kecamatan Gunungsitoli Idanoi Kota Gunungsitoli yang terdiri atas keluarga miskin dengan jumlah 313 kepala keluarga, dan yang menjadi sampel adalah bagian dari populasi dengan menggunakan teknik pengambilan sampel purposive sampling yang berarti sampel diambil dengan ketentuan peneliti karena adanya pertimbangan tertentu. Sementara data yang diperlukan adalah bersumber dari data primer dan data sekunder. Dari hasil penelitian bahwa fungsi pengawasan pendistribuasian Raskin di Desa Tetehosi I Kecamatan Gunungsitoli Idanoi telah dilakukan secara efektif dan sesuai dengan Pedoman Umum Raskin tahun 2016.
Peran Struktur Dewan Dalam Mempengaruhi Kinerja Pada Nilai Perusahaan Keluarga
Authors: Yopie Santi , Supriyanto Supriyanto , Chandra Budi
Published: November 2019

The family company is synonymous with the characteristics to inherit its company from one generation to the next. The average family company can only survive and inherit up to third generation (Wahjono, Wajoedi, & Idrus, S, 2014). However, there are also have some family companies especially in the field of estate in Scotland that can last up to 400, 600 even 800 years (Belmonte, Seaman, & Bent, 2016). The culture and application of the board structure of each family company varies greatly. The purpose of this study was to determine the effect of board structure (CEO family / non-family, professional qualification, board size, and independent commissioner) on the value of the company in the family enterprise. This research method is analyzed by multiple linear regression on panel data that is 125 family company in BEI 2010-2014. The results of this study indicate that family firms run by non-family (professional) CEOs will be higher in corporate value than the family CEO. Professional qualifications have a significant negative influence on the value of the company. The size of the board has a significant positive influence on firm value. Independent commissioners have no significant influence on the value of family firms.
The Effect of Compensation on Employee Performance at PT. Sango Indonesia - Karawang
Authors: Dwianto Agung Surya , Rustomo Rustomo , Aprurroji Andri
Published: November 2019

Employee performance is very important for the achievement of the goals of a company. One important factor that can affect performance in a company is from providing compensation given to employees. Compensation is something that is received by employees as a substitute for their service contribution to the company. The existence of a good compensation system will ensure the occurrence of justice between employees and the company. Each employee will receive a reward in accordance with the goals, functions, positions, and work performance

 Compensation problems are a sensitive problem because they are driving people to work hard. Besides that compensation also affects morale and labor discipline. Therefore, any company / organization should be able to provide compensation that is balanced with the workload borne by the workforce.

This research was conducted at PT. Indonesian Sango. The purpose of this study was to determine the effect of compensation on the performance of employees at PT. Indonesian Sango. PT. Sango Indonesia is a company engaged in the Automotive Part that produces Secondary Steel and Exhaust Manifold. Shareholders in PT. Sango Indonesia is divided into Sango Group, Toyota Thuso, Sumitomo Corporation, sumitomo corporation Indonesia and shinsho corporation. Meanwhile, the purpose of this study was to determine the effect of compensation on the performance of employees at PT. Indonesian Sango.

               Based on the results of the study it can be seen that Compensation has a contribution of influence of 50.83% on the performance of employees of PT. Indonesian Sango. While the remaining 49.17% is influenced by other factors. From the results of the study it can be concluded that compensation is needed to help strengthen the organization's key values ​​and facilitate the achievement of organizational goals

Keywords: Compensation, Employee
El delito silencioso contra las mujeres en la pareja
Authors: Valenzuela Mendívil Ana
Published: November 2019

Del debate internacional surgen dos hipótesis sobre el origen del maltrato a la mujer en la pareja :1)la "benigna", que considera que éste siempre ha existido e incluso en mayor medida, y la diferencia es que actualmente las mujeres se muestran más dispuestas a denunciar y 2)la de la "escalada" subraya que el cambio de rol social de las mujeres y su proceso de empoderamiento incrementa la violencia masculina, por las dificultades de ciertos varones para adaptarse y tratar a sus compañeras de igual a igual, renunciando a sus ancestrales privilegios de género, y por tanto, al dominio y control sobre la vida de ellas. Probablemente ambas hipótesis son ciertas y conocer los datos es importante, pero lo urgente entre otras medidas, es educar a hombres y mujeres, niños y niñas,sobre Derechos Humanos y leyes sobre la Igualdad de Género y publicitar las Instituciones que protegen a las mujeres para tener acceso a una vida libre de violencia.
The Difference on Pain and Range of Motion After High-Intensity Laser Therapy on Myositis Ossificans of the Right Deltoid Muscle: A Case Report
Authors: Herdiansyah Dian , Prabowo Tertianto , Goesasi Rachmat Z.
Published: November 2019

Background: Myositis Ossificans (MO) is a non-neoplastic proliferation of bone and cartilage tissue aftermicro-injuries on muscle, as a result of dysregulation response to inflammation on stem cells.Results: A patient, 50-years old man with pain and restricted movement of the right shoulder, that rose 8hours after exercise. The radiograph revealed the MO on the right Deltoid muscle. The patient has receivedthe high intensity of laser therapy for two continuous therapy. The result after therapy was decreased ofpain and can move the right shoulder easily. Furthermore, after two times/week for four weeks of therapy,there was no pain, as well as the x-ray was showed reduced the size of calcification.Conclusion, The high intensity of Laser therapy was improved the pain dan reduced the size of MO onright deltoid muscleKeywords: Myositis Ossificans, Deltoid Muscle, High Intensity of Laser Therapy
Human adaptation: why only genes?
Authors: Ibraimov AI
Published: November 2019

Adaptation of a human to different climatic and geographical conditions has two principal features: a) only man managed to master the entire land of the Earth, while remaining a single, tropical biological species (Homo sapiens sapiens); b) in contrast to animals, human colonization of all climatic-geographical provinces, including the extreme ones (Far North and high-altitude), occurred in a very short period of time. It remains unclear how it all was managed by a human. Regarding genetic mechanisms, the main question is not clarified: did a human adapt only with the help of genes, like all other living organisms, or did he use a means inherent only in H.s.sapiens? Our nearly half a century experience of studying the genetic mechanisms of human adaptation to the high-altitude climate of the Pamir and Tien-Shan, as well as to the Far North of Eastern Siberia, argues in favor of the non-gene part of the genome.

Keywords: Human adaptation; Cell thermoregulation; Hypobaric hypoxia; Chromosomal Q-heterochromatin; Human body heat conductivity
Chromosomal Q-heterochromatin Variability and Sport
Authors: Ibraimov AI
Published: November 2019

In the process of studying the variability of chromosomal Q-heterochromatin regions (Q-HRs) in human populations living permanently in different climatogeographic conditions of Eurasia and Africa, as well as in newcomers, who have successfully adapted to some extreme natural conditions, the data were obtained that, perhaps, the amount of this genetic material in the genome may be important for some sports. In particular, it turned out that in the genome of mountaineers the number of chromosomal Q-HRs was significantly lower than in the control sample and was close to that of the high-altitude natives. The same results were obtained in a comparative study of newcomers who have been working in the extreme climatic conditions of the Far North of West Siberia. We believe that these observations can be explained by cell thermoregulation (??) the level of which depends on the number of chromosomal Q-HRs. The essence of ?? is elimination of the temperature difference between the nucleus and cytoplasm. The effect of CT can be indirectly assessed by the level of the body heat conductivity (BHC). An individual with high BHC cannot make much progress in mountaineering and water sports due to the fact that their body cools rapidly. However, this individual can be more successful in sports which require effective heat-loss.

Keywords: Chromosomal Q-heterochromatin; Cell thermoregulation; Body heat conductivity; Sport genetics; Marathon, Mountaineering
Cell Thermoregulation: Reality or just a logical Construction?
Authors: AI Ibraimov
Published: November 2019

The existence of biological thermoregulation at the molecular and organism (physiological organ-based system of thermoregulation) levels is well known. The possibility of thermoregulation at the level of individual cells is discussed. By cell thermoregulation (CT) is meant the elimination of the temperature difference between the nucleus and cytoplasm, when, for one reason or another, the level of thermal energy in the nucleus becomes higher than of the cytoplasm. The CT hypothesis can shed light on some scattered facts and observations, known in different areas of biology and medicine, but without rational explanation. It is assumed that CT originated from the evolution of ncDNAs in the eukaryotic genome, and its material basis is condensed chromatin. Although the CT hypothesis has not yet been directly experimentally confirmed, nevertheless, its existence can be determined by indirect methods at the organism level.

Keywords: Cell thermoregulation; Condensed chromatin; Chromosomal heterochromatin regions; Human body heat conductivity
Pathogenicity of low heteroplasmic m.3243A>G variants requires confirmation
Authors: Josef Finsterer
Published: November 2019

Keywords: Mitochondrial disorder; Multisystem; mtDNA; Phenotype; Genotype

Correspondence

In a recent article, Yee et al. reported about a 31 years old Caucasian male with non-specific mitochondrial multiorgan disorder syndrome (MIMODS) due to the mtDNA variant m.3243A>G [1]. Phenotypic manifestations attributed to the mtDNA variant included diabetes, gastro-intestinal dysmotility, gastro-intestinal pseudo-obstruction, facial dysmorphism, pectus excavatus, nystagmus, ophthalmoparesis, cataract, hypoacusis since childhood, migraine, retinopathy, right retinal detachment (ablatio retinae), and sinus tachycardia [1]. We have the following comments and concerns.
Burkitt leukemia with atypical morphology and subsequent therapy-related acute myeloid leukemia
Authors: Weijie Li  , Linda D Cooley  , Joy Fulbright
Published: November 2019

A 10-year-old previous healthy boy presented with jaw pain for several weeks. Compete blood count revealed leukocytosis (WBC 41.08 X 109/L), anemia (Hemoglobin 79 g/L) and thrombocytopenia (platelet count 50 X 109/L). Peripheral blood (PB) and bone marrow (BM) smears (Figure 1, panels A and B) showed frequent small sized blasts with high nucleus-to-cytoplasm ratio, and hand-mirror morphology. Flow cytometry analysis of BM showed 75% blasts with surface kappa-restriction, strongly positive for CD38, CD20, CD45, and negative for CD34 (Figure 1, panels C to E). The blasts were negative for CD10 and TdT. Cytogenetic study showed a complex abnormal karyotype: 46,XY,del(1)(q23),add(3)(q25),t(8;14)(q24.1;q32.3),der(13)t(1;?;13)(q23;?;q13).

FISH analysis confirmed MYC gene rearrangement (Figure 1, panel F). Burkitt leukemia (BL) was diagnosed. Patient underwent chemotherapy per COG ANHL01P1 protocol and achieved complete remission. 17 months after chemotherapy, he developed thrombocytopenia and monocytosis. BM showed many immature or atypical monocytic cells (Figure 1, panel G). Cytogenetic study showed t(11;19)(q23;p13.1). FISH confirmed KMT2A rearrangement (Figure 1, panel H).
Long-Term Clinical Outcomes of Lupus Nephritis Patients Undergoing Peritoneal Dialysis: A Matched, Case-Control Study
Authors: Ye Hongjian , Cao Peiyi , Lin Jianxiong , Yang Xiao , Guo Qunying , Mao Haiping , Yu Xueqing , Chen Wei
Published: November 2019

The long-term clinical outcomes of peritoneal dialysis (PD) for patients with lupus nephritis (LN) have not been well researched. In the present study, we investigated the long-term prognosis of a Chinese PD cohort. This was a retrospective case-control study that included LN patients receiving PD treatment for more than 90 days from January 2006 to December 2012. Non-diabetic control patients were selected using a ratio of 1:2 for age- and gender-matching. The primary outcome was all-cause mortality. Secondary outcomes included technique failure and hospitalization rate. All patients were followed up to 31 December 2017. A total of 28 LN patients on PD (89.3% female, mean age 42.2±15.8 years) and 56 controls were included. After a median follow-up period of 53.1 months, 11 LN patients died. The cumulative 1-, 3-, and 5-year patient survival rates were 92.4%, 84.7%, and 67.6% in LN patients, and 100%, 93.5%, and 82.9% in the control group, respectively ( p = 0.035). After adjusting for confounders, LN was not significantly associated with mortality (hazard ratio [HR]: 1.39, 95% confidence interval [CI]: 0.45 – 4.26); However, LN was still an independent risk factor of technique failure (HR: 2.87, 95% CI: 1.08 – 7.66). Meanwhile, the LN group had significantly higher hospitalization and infection rates. In conclusion, LN patients undergoing PD had poor patient survival and technique survival, and higher hospitalization and infection rates.
Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis
Authors: Lacey Heather J , Gilchrist Cameron L M , Crombie Andrew , Kalaitzis John A , Vuong Daniel , Rutledge Peter J , Turner Peter , Pitt John I , Lacey Ernest , Chooi Yit-Heng , Piggott Andrew M
Published: November 2019

Chemical investigation of an undescribed Australian fungus, Aspergillus nanangensis, led to the identification of the nanangenines – a family of seven new and three previously reported drimane sesquiterpenoids. The structures of the nanangenines were elucidated by detailed spectroscopic analysis supported by single crystal X-ray diffraction studies. The compounds were assayed for in vitro activity against bacteria, fungi, mammalian cells and plants. Bioinformatics analysis, including comparative analysis with other acyl drimenol-producing Aspergilli, led to the identification of a putative nanangenine biosynthetic gene cluster that corresponds to the proposed biosynthetic pathway for nanangenines.
Double-detonation Models for Type Ia Supernovae: Trigger of Detonation in Companion White Dwarfs and Signatures of Companions’ Stripped-off Materials
Authors: Tanikawa Ataru , Nomoto Ken’ichi , Nakasato Naohito , Maeda Keiichi
Published: November 2019

We have studied double-detonation explosions in double-degenerate (DD) systems with different companion white dwarfs (WDs) for modeling Type Ia supernovae (SNe Ia) by means of high-resolution smoothed particle hydrodynamics (SPH) simulations. We have found that only the primary WDs explode in some of the DD systems, while the explosions of the primary WDs induce the explosions of the companion WDs in the other DD systems. The former case is a so-called dynamically-driven double-degenerate double-detonation (D6) explosion, or helium-ignited violent merger explosion. The SN ejecta of the primary WDs strip materials from the companion WDs, whose mass is ∼10−3
M
⊙. The stripped materials contain carbon and oxygen when the companion WDs are carbon–oxygen (CO) WDs with He shells ≲0.04 M
⊙. Since they contribute to low-velocity ejecta components as observationally inferred for iPTF14atg, D6 explosions can be counterparts of subluminous SNe Ia. The stripped materials may contribute to low-velocity C seen in several SNe Ia. In the latter case, the companion WDs explode through He detonation if they are He WDs and through the double-detonation mechanism if they are CO WDs with He shells. We name these explosions “triple” and “quadruple” detonation (TD/QD) explosions after the number of detonations. The QD explosion may be counterparts of luminous SNe Ia, such as SN 1991T and SN 1999aa, since they yield a large amount of 56Ni, and their He-detonation products contribute to the early emissions accompanying such luminous SNe Ia. On the other hand, the TD explosion may not yield a sufficient amount of 56Ni to explain luminous SNe Ia.
Chemical Cartography. II. The Assembly History of the Galactic Stellar Halo Traced by Carbon-enhanced Metal-poor Stars
Authors: Lee Young Sun , Beers Timothy C. , Kim Young Kwang
Published: November 2019

We present an analysis of the kinematic properties of stellar populations in the Galactic halo, making use of over 100,000 main-sequence turnoff (MSTO) stars observed in the Sloan Digital Sky Survey. After dividing the Galactic halo into an inner-halo region (IHR) and outer-halo region (OHR), based on the spatial variation of carbon-to-iron ratios in the sample, we find that stars in the OHR exhibit a clear retrograde motion of −49 ± 4 km s−1 and a more spherical distribution of stellar orbits, while stars in the IHR have zero net rotation (−3 ± 1 km s−1) with a much more radially biased distribution of stellar orbits. Furthermore, we classify the carbon-enhanced metal-poor (CEMP) stars among the MSTO sample in each halo component into CEMP-no and CEMP-s subclasses, based on their absolute carbon abundances, A(C), and examine the spatial distributions and kinematics associated with each subclass. The CEMP-no stars are the majority subclass of CEMP stars in the OHR (∼65%), and the minority subclass in the IHR (∼44%), similar to the results of several previous analyses. The CEMP-no stars in each halo region exhibit slightly higher counterrotation than the CEMP-s stars, but within statistical errors. The CEMP-no stars also show a more spherical distribution of orbits than the CEMP-s stars in each halo region. These distinct characteristics provide strong evidence that numerous low-mass satellite galaxies (similar to the ultra-faint dwarf galaxies) have donated stars to the OHR, while more massive dwarf galaxies provided the dominant contribution to the IHR.
Evolution of the Stellar Mass–Metallicity Relation. II. Constraints on Galactic Outflows from the Mg Abundances of Quiescent Galaxies
Authors: Leethochawalit Nicha , Kirby Evan N. , Ellis Richard S. , Moran Sean M. , Treu Tommaso
Published: November 2019

We present the stellar mass–[Fe/H] and mass–[Mg/H] relation of quiescent galaxies in two galaxy clusters at z ∼ 0.39 and z ∼ 0.54. We derive the age, [Fe/H], and [Mg/Fe] for each individual galaxy using a full-spectrum fitting technique. By comparing with the relations for z ∼ 0 Sloan Digital Sky Survey galaxies, we confirm our previous finding that the mass–[Fe/H] relation evolves with redshift. The mass–[Fe/H] relation at higher redshift has lower normalization and possibly steeper slope. However, based on our sample, the mass–[Mg/H] relation does not evolve over the observed redshift range. We use a simple analytic chemical evolution model to constrain the average outflow that these galaxies experience over their lifetime, via the calculation of mass-loading factor. We find that the average mass-loading factor η is a power-law function of galaxy stellar mass,

. The measured mass-loading factors are consistent with the results of other observational methods for outflow measurements and with the predictions where outflow is caused by star formation feedback in turbulent disks.
The Infall Motion in the Low-mass Protostellar Binary NGC 1333 IRAS 4A1/4A2
Authors: Su Yu-Nung , Liu Sheng-Yuan , Li Zhi-Yun , Lee Chin-Fei , Hirano Naomi , Takakuwa Shigehisa , Hsieh I-Ta
Published: November 2019

We report ALMA observations of NGC 1333 IRAS 4A, a young low-mass protostellar binary, whose components are referred to as 4A1 and 4A2. With multiple H2CO transitions and HNC (4−3) observed at a resolution of 0.″25 (∼70 au), we investigate the gas kinematics of 4A1 and 4A2. Our results show that on the large angular scale (∼10″), 4A1 and 4A2 each display a well-collimated outflow along the N–S direction, and an S-shaped morphology is discerned in the outflow powered by 4A2. On the small scale (∼0.″3), 4A1 and 4A2 exhibit distinct spectral features toward the continuum centroid, with 4A1 showing simple symmetric profiles predominantly in absorption and 4A2 demonstrating rather complicated profiles in emission as well as in absorption. Based on radiative transfer modeling exercises, we find that the physical parameters inferred from earlier low-resolution observations cannot be directly extrapolated down to the inner region of 4A1. Possible reasons for the discrepancies between the observed and modeled profiles are discussed. We constrain the mass infall rate in 4A1 to be at most around 3 × 10−5
M
⊙ yr−1 at the layer of 75 au. For the kinematics of the inner envelope of 4A2, the absorbing dips in the H2CO spectra are skewed toward the redshifted side and likely signatures of inward motion. These absorbing dips are relatively narrow. This is, like the case for 4A1, significantly slower than the anticipated inflow speed. We estimate a mass infall rate of (3.1–6.2) × 10−5
M
☉ yr−1 at the layer of 100 au in 4A2.
Intervenir sur les facteurs de risque de maltraitance infantile : quelle aisance chez les professionnels français de prévention précoce ?
Authors: Saïas Thomas , Kargakos Samantha , Poissant Julie , Eury Charles
Published: November 2019

La recherche portant sur la prévention de la maltraitance est limitée depuis 40 ans en champ expérimental. Si l’on sait comment des actions à domicile peuvent contribuer à limiter les situations de mauvais traitement aux enfants, on ne connait pas les enjeux liés à la réplication de ces résultats dans les soins courants. Cette étude avait pour objectif d’identifier, dans les services publics français, comment les professionnels de prévention abordent les facteurs de risque de maltraitance avec les familles, et avec quelle aisance. À travers ces notions, ce sont les compétences professionnelles qui sont interrogées, à la lumière des missions confiées à ces professionnels de prévention. Les résultats montrent que, au-delà d’une forme de polyvalence leur permettant d’aborder un large spectre de sujets avec les familles, les intervenants de prévention se déclarent très peu à l’aise pour traiter les sujets d’intimité familiale, de psychopathologie ou de violence envers les enfants. Les implications concernant les politiques de prévention de la maltraitance sont discutées.
L’étendue effective de la pratique des infirmières dans les services de proximité en région éloignée
Authors: Morin Mélanie , Lessard Lily
Published: November 2019

Les infirmières peuvent contribuer à accroître l’accessibilité aux services de santé et la qualité des soins à condition d’occuper pleinement leur champ de pratique. Cette étude réalisée au Québec dans une région éloignée des grands centres urbains vise à 1) mesurer l’étendue effective de la pratique infirmière dans les services de proximité et 2) déterminer les caractéristiques individuelles, professionnelles, organisationnelles et contextuelles l’influençant. Quarante-quatre (44) infirmières pratiquant dans différents types d’infrastructures de services de proximité ont répondu à une version électronique du Questionnaire sur l’étendue de la pratique infirmière portant sur 26 activités regroupées en six dimensions. Les résultats indiquent une étendue effective de la pratique infirmière sous-optimale. La dimension « optimisation de la qualité et de la sécurité des soins » obtient le score le plus faible tandis que celles liées à « l’évaluation et la planification des soins », à « l’enseignement aux personnes et leurs familles » et à « la mise à jour et l’utilisation des connaissances » obtiennent des scores plus élevés. Aucune caractéristique n’influence globalement l’étendue effective de la pratique infirmière, mais des scores significativement plus élevés ont été dénotés pour certaines dimensions chez les femmes, chez les infirmières travaillant à temps plein et pour les régions plus proches des grands centres. Cette étude lève en partie le voile sur la pratique infirmière dans les services de proximité en région éloignée afin de formuler des recommandations adaptées à ces contextes.
A Sharp estimate for the first Robin–Laplacian eigenvalue with negative boundary parameter
Authors: Bucur Dorin , Ferone Vincenzo , Nitsch Carlo , Trombetti Cristina
Published: November 2019

In this paper we prove that the ball maximizes the first eigenvalue of the Robin Laplacian operator with negative boundary parameter, among all convex sets of Rn with prescribed perimeter. The key of the proof is a dearrangement procedure of the first eigenfunction of the ball on the level sets of the distance function to the boundary of the convex set, which controls the boundary and the volume energies of the Rayleigh quotient.
Quasilinear elliptic equations with sub-natural growth terms and nonlinear potential theory
Authors: Verbitsky Igor E.
Published: November 2019

We discuss recent advances in the theory of quasilinear equations of the type

-\Delta_{p} u = \sigma u^{q}

in

\mathbb R^n

, in the case

0 < q < p-1

, where

\sigma

is a nonnegative measurable function, or measure, for the

p

-Laplacian

\Delta_{p}u= \mathrm{div}(|\nabla u|^{p-2}\nabla u)

, as well as more general quasilinear, fractional Laplacian, and Hessian operators.

Within this context, we obtain some new results, in particular, necessary and sufficient conditions for the existence of solutions

u \in \mathrm{BMO}(\mathbb R^n), u \in L^r_{{\mathrm loc}}(\mathbb R^n)

, etc., and prove an enhanced version of Wolff's inequality for intrinsic nonlinear potentials associated with such problems.
Eight(y) mathematical questions on fluids and structures
Authors: Bonheure Denis , Gazzola Filippo , Sperone Gianmarco
Published: November 2019

Turbulence is a long-standing mystery. We survey some of the existing (and sometimes contradictory) results and suggest eight natural questions whose answers would increase the mathematical understanding of this phenomenon; each of these questions, yet, gives rise to ten subquestions.
Singular solutions to a semilinear biharmonic equation with a general critical nonlinearity
Authors: Frank Rupert L. , König Tobias
Published: November 2019

We consider positive solutions

u

of the semilinear biharmonic equation

\Delta^2 u = |x|^{-\frac{n+4}{2}} g(|x|^\frac{n-4}{2} u)

in

\mathbb R^n \setminus \{0\}

with non-removable singularities at the origin. Under natural assumptions on the nonlinearity

g

, we show that

|x|^\frac{n-4}{2} u

is a periodic function of

\ln |x|

and we classify all such solutions.