bluuebunny/crossref_metadata_2025 huggingface dataset:
FONKSİYONEL BESİNLERİN OKSİDATİF STRES ÜZERİNE ETKİLERİ
Authors: EMİRHÜSEYİNOĞLU AYŞENUR , KOÇ ÖZERSON ZEYNEP , ALPHAN MÜVEDDET EMEL
Published: January 2025

Fonksiyonel besinler, içerdikleri biyoaktif bileşenler sayesinde sağlık üzerinde olumlu etkiler yaratabilen ve geleneksel besinlerden farklı olarak belirli sağlık hedeflerine
yönelik geliştirilen gıdalar olarak tanımlanır. Bu kavram, ilk kez 1980’lerde Japonya’da ortaya çıkmış ve o zamandan bu yana dünya genelinde hızla yaygınlaşarak gıda ve sağlık
endüstrilerinde önemli bir yere sahip olmuştur. Fonksiyonel besinler, yalnızca temel besin öğelerini sağlamanın ötesinde, düzenli ve yeterli düzeyde tüketildiklerinde vücutta
çeşitli sağlık yararları sunabilirler. Bu besinler, hastalıkların önlenmesine yardımcı olma, bağışıklık sistemini güçlendirme ve genel refahı artırma gibi potansiyellere sahiptir.
Fonksiyonel besinlerin içeriğinde bulunan antioksidanlar, özellikle oksidatif stresle mücadelede kilit bir rol oynar. Oksidatif stres, organizmada reaktif oksijen ve nitrojen türlerinin üretiminin artması ve vücudun doğal antioksidan savunma mekanizmalarının bu duruma karşı yetersiz kalması sonucu meydana gelir. Bu durum, hücre hasarına neden
olabilir ve kardiyovasküler hastalıklar, kanser, diyabet gibi birçok kronik hastalığın gelişiminde rol oynar. Fonksiyonel besinlerin içerdiği biyoaktif bileşenler, bu tür süreçlere
karşı vücudu koruyarak hastalık riskini azaltabilir ve sağlığı optimize edebilir. Böylece, fonksiyonel besinler hem koruyucu bir etki sunar hem de bireylerin günlük yaşam
kalitesini artırma potansiyeline sahiptir.
Fonksiyonel besinler, oksidatif stresle mücadelede ve vücuttaki biyokimyasal dengenin korunmasında önemli bir rol oynayabilir. Bu tür besinler, içerdikleri biyoaktif bileşenler
sayesinde vücudun savunma mekanizmalarını destekleyerek oksidatif stresin neden olduğu hücre hasarını azaltabilir. Örneğin, yeşil çay, polifenol adı verilen güçlü antioksidan
bileşenler bakımından zengindir. Bu polifenoller, vücutta serbest radikallerin etkisini azaltarak hücreleri korur ve oksidatif stresi minimize eder. Benzer şekilde, kahve de
biyoaktif bileşenler içerir ve nükleer faktör eritroid 2 yolaklarını aktive ederek hücresel koruyucu proteinlerin üretimini teşvik edebilir. Ancak bu etkiler, kanser hücrelerinde
istenmeyen sonuçlara yol açabilir. Akdeniz diyetinin vazgeçilmez bir öğesi olan zeytinyağının içerdiği bileşikler ile reaktif oksijen türlerinin oluşumunu azalttığı bilinmektedir.
EPA, antioksidan enzimlerin ifadesini artırırken, DHA mitokondriyal sağlığı destekleyip inflamasyonu azaltabilir. Kırmızı üzüm içeriğindeki resveratrol, antioksidan özellik göstererek çeşitli hastalıkların önlenmesine yardımcı olmaktadır. Yapılan klinik çalışmalarda, fonksiyonel ve besleyici özellikleri içeriğindeki ß-glukana atfedilen yulafın oksidatif stres
üzerine olumlu etkileri görülmüştür. Sonuç olarak, fonksiyonel besinlerin sağlıklı bireylerde oksidatif stresin azaltılmasında ve genel sağlık durumunun iyileştirilmesinde önemli
bir rol oynayabileceği görülmektedir.
Deskripsi Kemampuan Geometri Siswa Sekolah Dasar Berdasarkan Teori Van Hiele
Authors: Kusnadi Dedi , Safarudin Safarudin , Adiasti Nindya
Published: January 2025

Kemampuan siswa dalam pembelajaran geometri sangat penting untuk dikembangkan, karena kemampuan geometri siswa dapat menyelesaikan suatu permasalahan baik dalam pembelajaran matematika maupun dalam kehidupan sehari-hari. Kemampuan geometri sangat penting dalam meningkatkan gaya berpikir siswa. Teori Van Hiele menyatakan siswa akan melalui 5 tahapan berpikir jika siswa mempu memiliki kemampuan berpikir geometri. Adapun perkembangan berpikir geometri siswa sekolah dasar dalam pembelajaran matematika yaitu pada tahap Visualisasi dan Tahap Analisis. Penelitian ini bertujuan untuk mendeskripsikan kemampuan geometri siswa sekolah dasar berdasarkan teori Van Hiele. Metode yang digunakan dalam penelitian ini adalah deskripsi kualitatif. Dengan pengumpulan data melalui soal tes Van Hiele Geometri Tes (VHGT), yang diberikan kepada 23 siswa yang selanjutnya data siswa yang dikonfirmasikan melalui wawancara. Dapat diketahui bahwa terdapat 3 siswa yang masuk pada tahap visualisasi, 4 siswa yang dikatagorikan notif (tidak dapat ditentukan level berpikirnya berdasarkan teori van hiele). Sedangkan 16 siswa dikategorikan belum masuk dalam tahapan berpikir berdasarkan teori van hiele. Sehingga dalam penelitian ini yang menjadi subjeknya adalah 3 siswa yang masuk pada tahap visualisasi. Hasil penelitian menunjukkan bahwa ketiga subjek HR, NF, dan MR memiliki kemampuan geometri dalam memahami suatu bangun datar berdasarkan bentuk yang terlihat secara visual, dimana ketiga subjek dapat membedakan segitiga, persegi, persegi panjang, dan mana yang merupakan jajargenjang. Selain itu subjek tidak dapat menjawab soal pada tahapan-tahapan berikutnya.
Analisis Isi Pesan Moral dalam Film Rumah Masa Depan Karya Ali Shahab Tahun 2023
Authors: Lbs Reihani Fadilla , Khohar Abdul , Pamungkas Andhika
Published: January 2025

Kehidupan manusia dan komunikasi terkait erat. Melalui penggunaan sistem pesan dan simbol, interaksi sosial terjadi. Komunikasi langsung dan tidak langsung memiliki peran yang signifikan dalam kehidupan manusia. Informasi dan wawasan dapat ditambahkan melalui komunikasi. Salah satu istilah yang dikenal oleh kebanyakan orang saat ini adalah “film”. Karena film berbentuk audiovisual, yang menyiratkan bahwa film mengandung pesan, maka film dapat dianggap sebagai alat komunikasi yang ampuh. Film ini menyampaikan sejumlah pesan, salah satunya adalah pesan moral. Ada banyak jenis pesan moral yang dapat dikomunikasikan. Menyediakan materi sinematik yang luas kepada masyarakat adalah salah satunya. Film merupakan salah satu bentuk media komunikasi massa yang menyajikan pesan secara efektif. Film tidak hanya menyajikan pengalaman yang seru, tetapi juga berkaitan dengan pengalaman hidup sehari-hari yang dikemas secara menarik, seperti yang tergambar dalam film keluarga berjudul “Rumah Masa Depan”. Dengan menggunakan analisis semiotika John Fiske, penelitian ini berfokus untuk mengetahui pesan moral yang terkandung dalam film “Rumah Masa Depan” melalui tataran realitas, tataran representasi, dan tataran ideologi. Hasil penelitian ini menunjukkan bahwa pesan moral yang terkandung dalam film “Rumah Masa Depan” direpresentasikan melalui ekspresi, dialog, dan interaksi antara orang tua dan anak.
Implementasi Program Pendidikan Kewirausahaan terhadap Anak Inklusi pada SDN Klagen Sukodono Kabupaten Sidoarjo
Authors: Fahrurrozi Muhammad , Khamidi Amrozi , Murtadlo Murtadlo
Published: January 2025

Penelitian ini menyelidiki penerapan program pendidikan kewirausahaan untuk anak inklusif di SDN Klagen Sukodono, Kabupaten Sidoarjo. Dengan pendekatan kualitatif, penelitian ini mengeksplorasi penerapan program, faktor pendukung, dan tantangan yang dihadapi. Inisiatif ini terintegrasi dengan Proyek Penguatan Profil Pelajar Pancasila (P5), yang berfokus pada kegiatan berbasis lokal, seperti mengolah tanaman TOGA menjadi produk jamu tradisional. Hasil penelitian menunjukkan bahwa program ini berhasil meningkatkan keterampilan sosial, kemandirian, dan kreativitas anak inklusif, sambil membangun empati siswa reguler melalui kolaborasi kelompok. Faktor pendorong utama meliputi dukungan dari kurikulum merdeka dan partisipasi aktif masyarakat setempat. Namun, tantangan signifikan masih ada, seperti fasilitas yang terbatas dan kurangnya jumlah guru pendamping khusus. Penelitian ini menyoroti peran penting strategi kolaboratif dan adaptif dalam menciptakan lingkungan belajar inklusif yang memberikan manfaat bagi semua siswa.
Strategi Penguatan Pendapatan Daerah dan Pengembangan Kemandirian Ekonomi Lokal Melalui Instrumen Ekonomi Islam: Studi Tentang Zakat, Infaq, Sedekah, dan Wakaf
Authors: Budiyono Anton , Hopia Nida
Published: January 2025

This study aims to examine how zakat, infaq, sadaqah, and waqf can be used strategically to strengthen regional income and encourage local economic independence. This study uses a descriptive qualitative approach. The research subject of this article is Islamic economic instruments which include zakat, infaq, alms, and waqf, as well as their role in increasing local income and building regional economic independence. The data were analyzed using descriptive qualitative methods. The results of the analysis show that the use of zakat, infaq, alms, and waqf has significant potential to increase regional revenue and alleviate poverty. With good and integrated management in public financial policies, zakat, infaq, alms, and waqf can be a solution for sustainable financial and economic independence that is able to overcome various social problems in society. Increasing literacy, professional management, and the use of digital technology will be the key to success in optimizing the potential of zakat, infaq, alms, and waqf in the future, so that the economic independence of a region can be realized properly and effectively
Audit Komunikasi Program Intervensi Keamanan Pangan Jajanan Anak Sekolah Balai Besar Pengawas Obat dan Makanan di Yogyakarta
Authors: Wulandari Wulandari , Suparno Basuki Agus , Prayudi Prayudi
Published: January 2025

Pangan Jajanan Anak Sekolah (PJAS) yang tidak aman dapat menyebabkan berbagai macam penyakit. Salah satu upaya yang dilaksanakan untuk mengatasi permasalahan keamanan pangan adalah dengan Program Intervensi Keamanan PJAS. Kondisi Pandemi COVID-19 mengakibatkan redefinisi PJAS dan perubahan pola komunikasi pada pelaksanaan program. Penelitian ini bertujuan untuk mengevaluasi keberhasilan Program Intervensi Keamanan PJAS yang dilaksanakan oleh BBPOM di Yogyakarta pada masa Pandemi COVID-19 dan faktor-faktor apa yang menjadi penghambat berdasar hasil audit komunikasi. Metode penelitian yang digunakan adalah metode evaluatif dengan kualitatif melalui wawancara informan untuk menggali perencanaan dan persiapan dan survei komunitas sekolah untuk melihat tanggapan pelaksanaan program berdasar dimensi komunikasi yang mengacu Pedoman Umum Audit Komunikasi di Lingkungan Instansi Pemerintah. Hasilnya menunjukkan bahwa Program Intervensi Keamanan PJAS berjalan baik dan dapat terus dilanjutkan dengan mengoptimalkan performa pada dimensi komunikasi, yaitu proses penyampaian pesan dengan melaksanakan komunikasi secara langsung dengan pengambil kebijakan, media komunikasi dengan penambahan media hardcopy, kejelasan arti pesan dengan membuat satu pointers atau poster yang berisi tahapan program secara utuh, umpan balik publik dengan melaksanakan sharing informasi dan audiensi untuk mendorong partisipasi sekolah tingkat SMP dan SMA, dan model komunikasi yang diterapkan dengan perluasan penggunaan media promosi program. Berdasarkan analisis hasil audit komunikasi Program Intervensi Keamanan PJAS yang dilaksanakan BBPOM di Yogyakarta di masa Pandemi COVID-19 ini dapat disimpulkan bahwa program ini berhasil dilaksanakan dengan baik, lancar dan sesuai dengan perencanaan. Program berjalan sesuai dengan yang diharapkan, hambatan yang timbul tidak signifikan dan dapat teratasi dengan pengelolaan yang baik.
Gender Differences in English Language Anxiety among Moroccan University Students: A Cross-Sectional Study
Authors: Baba Khouya Youssef
Published: January 2025

This study focuses on gender differences in English Language anxiety among Moroccan students. A structured questionnaire was employed for data collection by adopting a cross-sectional research design. The respondents comprised 240 university students; the questionnaire included respondents’ demographic data and the English Language Classroom Anxiety Scale (ELCAS). The study aimed to answer three research questions: (1) Does gender significantly influence English language anxiety among Moroccan students? (2) What variables cause male and female students’ English language anxiety? (3) How does English language anxiety affect male and female students’ academic achievement and well-being? The study affirms that the level of English anxiety significantly differs by gender, and the female students had higher English anxiety. Some significantly identified factors include fear of negative evaluation and communication apprehension. The study thus advocates for tailored intervention to address gender-specific language anxiety and promote the student’s academic achievement and well-being.
Towards Campus Integrity: Integrating Anti-Corruption Education with Islamic Religious Education
Authors: Ulum Bachrul , Astutik Leny Suryaning , Janattaka Nugrananda , Zaini Moh. , Riswadi Riswadi , Amrullah Zen
Published: January 2025

The widespread corruption in Indonesia is a major obstacle to the country's economic and social progress. Instilling anti-corruption values in the next generation is a critical responsibility of higher education institutions. This study looks at how Islamic Religious Education classes in Indonesian universities have begun to incorporate lessons about against corruption. The faculty and students of Bhinneka PGRI University participated in a qualitative case study. Documentation, in-depth interviews, participant observation, and focus groups were used to obtain facts. The findings demonstrated that a number of strategies were employed to incorporate anti-corruption education into Islamic Religious Education courses. These included reviewing the curriculum and syllabus, creating interactive teaching materials and methods, and organising student activities to promote a culture that rejects corruption. Integrity, compassion, autonomy, discipline, responsibility, hard work, simplicity, courage, and fairness are nine anti-corruption principles that were found to be included in the course materials. Additionally, a number of successful learning strategies were implemented, including learning through projects, learning in context, learning in collaboration, learning through discovery, value clarification tools, and modelling good behaviour. Students are encouraged to cultivate their character and integrity through the incorporation of anti-corruption instruction within Islamic Religious instruction classes. This will equip them to take on leadership roles in the fight against corruption in the future. University syllabi should incorporate anti-corruption education, according to this report, and additional research into alternative learning modalities should be pursued to foster an anti-corruption culture on campus.
Babyblues Syndrome in the Quran: A Contextual Analysis of Surah Maryam Verses 21-30
Authors: Fadlilah Annisa , Christiani Putri Margareta Lucky
Published: January 2025

Baby blues, also known as postpartum blues, is a temporary mood disorder that can affect new mothers. This syndrome experienced by these women can occur due to many factors, internal and external. This research looks at the phenomenon of Baby blues syndrome experienced by Maryam in Surah Maryam 21-30. The method applied in this research is the thematic method for certain letters using Abdullah Saeed's Contextual Tafsir theory. The research sources are the Al-Qur'an and Tafsir Books, in this case, the research object is Surah Maryam verses 21-30. The results of the research are: identification of the world of the text shows that Maryam's letter fell into patriarchal social conditions; the structure of the text in this letter coherently describes the process of Maryam's pregnancy until she gave birth to Isa amidst the ridicule of the children of Israel; Recipients of revelation viewed the text during the time of the prophet Muhammad who already knew Isa with a different concept; The contextual interpretation of Maryam's letter 21-30 is the phenomenon of Baby blues syndrome experienced by Maryam; Maryam's support system in giving birth to Isa as prevention of baby blues; Nutrition for pregnant women, and external pressure and how to overcome it as an effort to avoid baby blues syndrome.
REVISÃO INTEGRATIVA SOBRE A TRIAGEM E O DIAGNÓSTICO DE PACIENTES PARA A PREVENÇÃO OU DETECÇÃO PRECOCE DO CÂNCER DE COLO DE ÚTERO NO BRASIL
Authors: Ó Maria Julia Ferrari do , Fukushima André Rinaldi , Nicoletti Maria Aparecida
Published: January 2025

Considerando que o câncer cervical é um problema significativo, principalmente empaíses com disparidades econômicas e sociais, como o Brasil, é importante revisar as estratégias empregadas no Programa Nacional de Controle do Câncer de Colo do Útero para auxiliar na eficácia dele e no controle do câncer cervical no país. Com isso, o presente trabalho teve por objetivos descrever a triagem e diagnóstico do câncer de colo do útero realizada em mulheres de 25 a 64 anos, bem como verificar a cobertura vacinal contra o HPV em adolescentes de 9 a 14 anos. Além disso, a fim de identificar possíveis aprimoramentos no processo de rastreio, foi realizada uma abordagem comparativa do Programa Nacional de Controle do Câncer de Colo do Útero no Brasil com os programas do Chile e da Austrália.A presente revisão integrativa, foi dividida em cinco etapas, que consistiram na formulação da questão norteadora; na coleta de dados em bases como o DATASUS, PubMed, EMBASE, Lilacs, Biblioteca Virtual em Saúde, além de políticas públicas de saúde, e Federação Internacional Farmacêutica; na avaliação e seleção dos dados; na análise e interpretação dos estudos selecionados e por fim na apresentação e discussão dos resultados obtidos no estudo de revisão.Foi constatado que no Brasil e no Chile, a desigualdade social afeta o acesso aos cuidados em saúde, enquanto na Austrália a cobertura de acesso é maior e menos desigual. Os métodos de diagnóstico variam: Brasil utiliza o Papanicolau, Austrália adota o teste de HPV baseado em DNA, e o Chile combina ambos os métodos. A vacinação é uma estratégia comum, sendo obrigatória nas escolas do Chile e da Austrália. A Austrália e o Brasil utilizam recrutamento ativo, enquanto no Chile o recrutamento é feito de maneira oportunista. Com base na revisão da literatura, concluiu-se que a triagem do HPV no Brasil enfrenta limitações, com baixa cobertura e adesão. Sugere-se possíveis melhorias norastreamento, como a adoção de testes de HPV baseado em DNA, campanhaseducativas, e implementação de avaliação externa da qualidade nos laboratórios para aumentar a confiabilidade dos resultados dos exames.
TRANSFORMAÇÕES ECONÔMICAS, CULTURAIS E TECNOLOGICAS - VIOLÊNCIA FINANCEIRA CONTRA IDOSO: ARTIGO 102 DA LEI 10.741/03
Authors: Tolentino Sandra Pereira Paulino
Published: January 2025

A violência financeira contra idosos é uma forma recorrente de abuso que compromete a autonomia e a qualidade de vida dessa população. Este artigo busca compreender o fenômeno, abordando sua conceituação, tipologias e implicações sociais, legais e econômicas. Por meio de uma revisão bibliográfica qualitativa, discute-se o impacto das políticas públicas, com ênfase no artigo 102 do Estatuto do Idoso, que criminaliza práticas como a retenção de benefícios financeiros. Também são exploradas estratégias preventivas, como a educação financeira e o fortalecimento das redes de apoio social e familiar, essenciais para mitigar esse problema. Os resultados indicam que, embora existam marcos legais relevantes, a eficácia das ações de combate à violência financeira ainda é limitada por desafios como a subnotificação, a falta de conscientização e lacunas institucionais. O estudo conclui pela necessidade de uma abordagem integrada que inclua educação, políticas públicas eficazes e fortalecimento da proteção social para garantir o respeito e a dignidade aos idosos.
La entrada en la vida adulta de hombres y mujeres a través de las generaciones en España (1920-2000).Estudio 3233 del Centro de Investigaciones Sociológicas
Authors:   Universidad de Montreal (Quebec, Canadá), Simó Noguera Carles Xavier , Moreno Mínguez Almudena , Gil Solsona David ,   Universidad de Valencia
Published: January 2025

Encuesta realizado por el CIS con el título Biografías de Emancipación, Generaciones y Cambio Social en España. Este módulo se diseñó para recoger información retrospectiva con el objetivo de estudiar las trayectorias vitales en la juventud, a partir de las generaciones de hombres y de mujeres de 18 y más años de edad, poniendo un especial interés en el proceso de emancipación. Todo ello, en un contexto de limitados datos generacionales sobre la juventud y sobre sus procesos de emancipación. La emancipación ha sido considerada en este estudio como una suma de procesos que implican distintas dimensiones, entre las que la salida o salidas del hogar parental son un evento más dentro de una «trayectoria» compleja. Los resultados obtenidos confirman evidencias empíricas encontradas en otros estudios y dan cuenta de aspectos también novedosos. El estudio cubre, además, un amplio rango de generaciones, muy diferentes entre sí, que han protagonizado cambios sociales profundos en sus trayectorias hacia la vida adulta. Ello nos sitúa en un contexto novedoso desde el que retomar el debate sobre la emancipación en España. Cabe destacar que los cambios más importantes se concentran entre las generaciones nacidas hasta 1959 y las nacidas después. Las transiciones juveniles de las generaciones más recientes muestran una clara tendencia hacia una mayor complejización, con una mayor presencia de recorridos no lineales y reversibles. Al mismo tiempo, hemos encontrado evidencias de que las trayectorias de las generaciones más mayores no eran tan lineales como estudios precedentes han sugerido. Este trabajo también aporta evidencias sólidas de que son las mujeres las que han protagonizado los cambios más notables. Entre ellas, los cambios sucedidos entre las generaciones de más edad y las más jóvenes son de mucho mayor calado que entre los hombres
Mediating role of self-esteem in the relationship between parental disapproval of the child and alexithymic personality
Authors: Yöyen Elif , Kılıç Ali Rıfat
Published: January 2025

BACKGROUND

Alexithymia is defined as difficulties in identifying, expressing, and understanding emotions. An unapproving environment during childhood is defined as the child not receiving emotional approval from their parents, being punished, or having their emotions devalued. The formation of self-esteem is shaped by the influence of parental behavior during childhood. The communication that the child establishes with their parents contributes to their increased self-esteem and sense of importance. The absence of this may play a role in developmental psychopathology.

AIM

To examine the mediating role of self-esteem in the relationship between a disapproving environment in childhood and alexithymia.

METHODS

The research in the relational screening model was conducted with 404 participants. Demographic Information Form, Disapproving Environment Scale in Childhood, Toronto Alexithymia Scale, and Rosenberg Self-Esteem Scale were used as data collection tools. Hayes’ bootstrapping technique was used in the analysis of the data obtained from the research.

RESULTS

As a result of the analyses, parental disapproval positively predicted the level of alexithymia (rmother = 0.51, rfather = 0.52, P < 0.05) and negatively predicted self-esteem (rmother = -0.75, rfather = -0.67, P < 0.05). Additionally, self-esteem negatively predicted alexithymia (r = -0.58, P < 0.05). It was observed that self-esteem had a partial mediating effect on the relationship between parental disapproval and alexithymia. Family types were analyzed separately as chaotic, approving, perfect, and typical. Of these, the chaotic family type positively predicted alexithymia (r = 0.33, P < 0.05) and negatively predicted self-esteem (r = -0.60, P < 0.05). The approving family type negatively predicted alexithymia (r = -0.43, P < 0.05) and positively predicted self-esteem (r = 0.61, P < 0.05). The perfect family type negatively predicted alexithymia (r = -0.27, P < 0.05) and positively predicted self-esteem (r = -0.45, P < 0.05).

CONCLUSION

The type of family in which the child grows up in and parental disapproval during childhood affected the child’s self-esteem and caused alexithymic personality traits.
Integrative transcriptomic and proteomic analysis reveals that SERPING1 inhibits neuronal proliferation via the CaMKII-CREB-BDNF pathway in schizophrenia
Authors: Li Feng , Ren Xing , Liu Jia-Xiu , Wang Tian-Dao , Wang Bi , Wei Xiao-Bin
Published: January 2025

BACKGROUND

Schizophrenia (SZ), a chronic and widespread brain disorder, presents with complex etiology and pathogenesis that remain inadequately understood. Despite the absence of a universally recognized endophenotype, peripheral blood mononuclear cells (PBMCs) serve as a robust model for investigating intracellular alterations linked to SZ.

AIM

To preliminarily investigate potential pathogenic mechanisms and identify novel biomarkers for SZ.

METHODS

PBMCs from SZ patients were subjected to integrative transcriptomic and proteomic analyses to uncover differentially expressed genes (DEGs) and differentially expressed proteins while mapping putative disease-associated signaling pathways. Key findings were validated using western blot (WB) and real-time fluorescence quantitative PCR (RT-qPCR). RNAi-lentivirus was employed to transfect rat hippocampal CA1 neurons in vitro, with subsequent verification of target gene expression via RT-qPCR. The levels of neuronal conduction proteins, including calmodulin-dependent protein kinase II (caMKII), CREB, and BDNF, were assessed through WB. Apoptosis was quantified by flow cytometry, while cell proliferation and viability were evaluated using the Cell Counting Kit-8 assay.

RESULTS

The integration of transcriptomic and proteomic analyses identified 6079 co-expressed genes, among which 25 DEGs were significantly altered between the SZ group and healthy controls. Notably, haptoglobin (HP ), lactotransferrin (LTF ), and SERPING1 exhibited marked upregulation. KEGG pathway enrichment analysis implicated neuroactive ligand-receptor interaction pathways in disease pathogenesis. Clinical sample validation demonstrated elevated protein and mRNA levels of HP , LTF , and SERPING1 in the SZ group compared to controls. WB analysis of all clinical samples further corroborated the significant upregulation of SERPING1 . In hippocampal CA1 neurons transfected with lentivirus, reduced SERPING1 expression was accompanied by increased levels of CaMKII, CREB, and BDNF, enhanced cell viability, and reduced apoptosis.

CONCLUSION

SERPING1 may suppress neural cell proliferation in SZ patients via modulation of the CaMKII-CREB-BDNF signaling pathway.
Sodium channel mutation SCN1A T875M, D188V and associated dysfunction with drug resistant epilepsy
Authors: Dabla Pradeep Kumar , Gupta Swapan , Singh Swati , Viswas Aroop , Yadav Manisha , Sonkar Subash Chandra , Koner Bidhan Chandra
Published: January 2025

BACKGROUND

The NaV1.1 sodium channel alpha subunit, encoded by SCN1A , is crucial for initiating and propagating action potentials in neurons. SCN1A gene has long been an established target in the etiology and therapy of epilepsy. However, very few studies have investigated the relevance of genetic variations in epilepsy and anti-epileptic drug resistance.

AIM

To investigate associations between polymorphisms, rs121917953 T/A and rs121918623 C/T, and drug resistance in epilepsy patients in the north Indian population.

METHODS

A total of 100 age- and sex-matched epilepsy patients (50 drug responsive and 50 drug resistant subjects) were recruited and SCN1A rs121918623 C/T* and rs121917953 T/A* polymorphisms were analyzed by the allele specific-PCR technique. χ 2 and Fisher’s exact test were used to estimate differences between the distribution of SCN1A rs121918623 and rs121917953 gene polymorphisms among various groups. The association between distinct rs121917953 genotypes and drug resistance was analyzed using logistic regression analysis.

RESULTS

For the SCN1A rs121917953 T/A* (D188V) polymorphism, a significantly higher proportion of individuals with AT genotype were observed in the drug-resistant group as compared to the drug-responsive group. Additionally, a higher risk association was exhibited by AT genotype for drug resistance with an odds ratio of 3.51 and P value = 0.017. For the SCN1A rs121918623 C/T* (T875M) polymorphism, no significant difference in genotype distribution was observed between the drug-resistant and drug-sensitive groups.

CONCLUSION

Our findings indicate that the SCN1A polymorphism D188V is associated with a higher risk of drug resistance for the AT variant as compared to the homozygous TT wild-type. Further research is needed at the functional level and in larger cohorts to determine the potential of these genes as a therapeutic target in epilepsy subjects.
Attribution of psychiatric manifestations to systemic lupus erythematosus in Chinese patients: A retrospective study
Authors: Geng Wen-Qi , Yang Xiao-Xi , Cao Jin-Ya , Zhang Shang-Zhu , Jiang Yi-Nan , Wei Jing
Published: January 2025

BACKGROUND

Not all neuropsychiatric (NP) manifestations in patients with systemic lupus erythematosus (SLE) are secondary to lupus. The clarification of the cause of NP symptoms influences therapeutic strategies for SLE.

AIM

To understand the attribution of psychiatric manifestations in a cohort of Chinese patients with SLE.

METHODS

This retrospective single-center study analyzed 160 inpatient medical records. Clinical diagnosis, which is considered the gold standard, was used to divide the subjects into a psychiatric SLE (PSLE) group (G1) and a secondary psychiatric symptoms group (G2). Clinical features were compared between these two groups. The sensitivity and specificity of the Italian attribution model were explored.

RESULTS

A total of 171 psychiatric syndromes were recorded in 138 patients, including 87 cases of acute confusional state, 40 cases of cognitive dysfunction, 18 cases of psychosis, and 13 cases each of depressive disorder and mania or hypomania. A total of 141 (82.5%) syndromes were attributed to SLE. In contrast to G2 patients, G1 patients had higher SLE Disease Activity Index-2000 scores (21 vs 12, P = 0.001), a lower prevalence of anti-beta-2-glycoprotein 1 antibodies (8.6% vs 25.9%, P = 0.036), and a higher prevalence of anti-ribosomal ribonucleoprotein particle (rRNP) antibodies (39.0% vs 22.2%, P = 0.045). The Italian attribution model exhibited a sensitivity of 95.0% and a specificity of 70.0% when the threshold value was set at 7.

CONCLUSION

Patients with PSLE exhibited increased disease activity. There is a correlation between PSLE and anti-rRNP antibodies. The Italian model effectively assesses multiple psychiatric manifestations in Chinese SLE patients who present with NP symptoms.
Neutrophil gelatinase-associated lipocalin as a biomarker for neuropsychiatric complications in acute ischemic stroke
Authors: Okpete Uchenna E , Byeon Haewon
Published: January 2025

This study evaluates the findings of Gu et al , who investigated the role of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for predicting neuropsychiatric complications in acute ischemic stroke (AIS) patients. The results revealed that elevated serum NGAL levels at admission are associated with a higher risk of cognitive impairment, anxiety, and depressive symptoms at discharge. The study analyzed 150 AIS patients (mean age 65.4 years, 58% male) using the Mini-Mental State Examination and the Hospital Anxiety and Depression Scale to assess neuropsychiatric outcomes. Multivariate analysis demonstrated that higher NGAL levels were independent predictors of cognitive impairment [odds ratio (OR) = 1.42], anxiety (OR = 1.28), and depression (OR = 1.39). Notably, NGAL exhibited strong predictive power for cognitive impairment, with an area under the curve of 0.78. Despite these promising findings, NGAL’s clinical utility is limited by its non-specificity across various conditions. Nevertheless, NGAL levels could help identify AIS patients at risk for neuropsychiatric complications, enabling timely intervention and comprehensive neuropsychiatric evaluation. The study emphasizes the need for further research to validate NGAL’s predictive accuracy and specificity in diverse AIS populations and advocates for its integration with other diagnostic modalities to enhance clinical decision-making.
Comprehensive view of suicide: A neuro-immune-endocrine approach
Authors: Ponce-Regalado María D , Becerril-Villanueva Enrique , Maldonado-García José Luis , Moreno-Lafont Martha C , Martínez-Ramírez Gabriela , Jacinto-Gutiérrez Salomón , Arreola Rodrigo , Sánchez-Huerta Karla , Contis-Montes de Oca Arturo , López-Martínez Karla María , Bautista-Rodríguez Elizabeth , Chin-Chan José Miguel , Pavón Lenin , Pérez-Sánchez Gilberto
Published: January 2025

Suicide is defined as the act of a person attempting to take their own life by causing death. Suicide is a complex phenomenon that is influenced by a multitude of factors, including psychosocial, cultural, and religious aspects, as well as genetic, biochemical, and environmental factors. From a biochemical perspective, it is crucial to consider the communication between the endocrine, immune, and nervous systems when studying the etiology of suicide. Several pathologies involve the bidirectional communication between the peripheral activity and the central nervous system by the action of molecules such as cytokines, hormones, and neurotransmitters. These humoral signals, when present in optimal quantities, are responsible for maintaining physiological homeostasis, including mood states. Stress elevates the cortisol and proinflammatory cytokines levels and alter neurotransmitters balance, thereby increasing the risk of developing a psychiatric disorder and subsequently the risk of suicidal behavior. This review provides an integrative perspective about the neurochemical, immunological, and endocrinological disturbances associated with suicidal behavior, with a particular focus on those alterations that may serve as potential risk markers and/or indicators of the state preceding such a tragic act.
Improving the outcome in leukemia patients by controlling subthreshold depression and cancer-related fatigue
Authors: Xiang Fa-Yang , Li Xin-Ke
Published: January 2025

Patients with leukemia often suffer from the combined effects of cancer-related fatigue (CRF) and subthreshold depression, which mutually exacerbate each other in a vicious cycle. In this editorial, we comment on the article by Liu et al , published in the World Journal of Psychiatry . We further elucidate the profound impact of subthreshold depressive symptoms on the experience of CRF and complications in patients with leukemia. This editorial highlights the importance of early identification and treatment of subclinical depression, and advocates for a multidisciplinary and integrated treatment approach that includes social support, psychological interventions, and individualized treatment plans. Future research needs to explore the biological mechanisms underlying the interaction between the two to develop more effective prevention and treatment strategies.
Progress In Deep Fake And Tampering : An In-Depth Analysis
Authors:   Department of Computer Science and Engineering, PESITM, Shimoga, S Dr. Chethan L
Published: January 2025

The rise of deep fake technology has ignited widespread societal apprehensions about potential security risks and the dissemination of false information. Despite extensive research into deepfake detection, effectively discerning low-quality deepfakes and simultaneously identifying variations in their quality remains a significant and formidable challenge. This investigation explores the dynamic field of deep fake detection, focusing specifically on video analysis targeting facial manipulations. The study introduces Celeb-DF, a substantial dataset comprising high- quality deep fake videos of celebrities, challenging prevailing detection methods. Additionally, a revolutionary Quality-Agnostic Deep Fake Detection (QAD) framework addresses the intricate task of simultaneously recognizing diverse qualities of deep fakes, surpassing established benchmarks across multiple datasets. The paper highlights ongoing efforts to enhance deep fake detection strategies, incorporating advanced models such as Stable Diffusion, and employing interpretability-through-prototypesn by merging fine-tuned Vision Transformers with Support Vector Machines.

Keywords -- Deep fake technology, security risks, deep fake detection, Celeb-DF dataset, video analysis, Quality-Agnostic Deep Fake Detection (QAD), Stable Diffusion, Vision Transformers, Support Vector Machines.
Web Development Barriers and Challenges
Authors:   ost Graduate Department of Computer Science, Kolhan University, WestSingbhum, Chaibasa, Jharkhand, India, Gorai S. K.
Published: January 2025

Web development plays a central role in the modern digital landscape, powering websites and applications that are vital for communication, business, and entertainment. However, the process of developing websites is not without its challenges. These barriers can be technical, organizational, or user-centric, and they impact the development cycle, the quality of the final product, and the user experience. This paper aims to explore the various challenges that web developers face, providing a detailed analysis of these obstacles and proposing potential solutions. It also examines how these challenges affect the development process and offers insights into how businesses and developers can overcome them. Through a deeper understanding of these issues, we can ensure that web development continues to evolve in a way that meets the growing demands of users and businesses alike.

Key words: Web Development, Barriers in Web Development, Challenges in Web Development, Front end Development, Backend Development, Full Stack Development, Web technology, Cross browser compatibility, Security concern, User experience, Web Accessibility, Organisational barrier, Technical challenges, Budget Constraints, Talent shortage.
BÁO CÁO CA LÂM SÀNG: U QUÁI BUỒNG TRỨNG XOẮN ĐẾN MUỘN HAY LIPOSARCOMA – KINH NGHIỆM TỪ SỰ NHẦM LẪN
Authors: Lê Văn Khảng , Ngô Ngọc Minh
Published: January 2025

Xoắn u quái buồng trứng là một biến chứng khá thường gặp và nghiêm trọng của bệnh lý u quái buồng trứng (hay còn gọi là u nang bì buồng trứng hoặc teratoma)1. Chẩn đoán hình ảnh đóng một vai trò quan trọng trong việc chẩn đoán xác định và đưa ra phương pháp điều trị sớm cho bệnh nhân1. Phẫu thuật cấp cứu được tiến hành nhanh chóng để giảm triệu chứng cũng như tránh nguy cơ nhiễm độc do khối u hoại tử, biến chứng vỡ u gieo rắc mô u vào phúc mạc2. Tuy nhiên một số ít khối u nang bì buồng trứng xoắn diễn biến chậm, triệu chứng lâm sàng và hình ảnh không điển hình gây khó khăn trong chẩn đoán và điều trị kịp thời cho bệnh nhân. Chúng tôi báo cáo một trường hợp khối u nang bì buồng trứng xoắn trước đó được chẩn đoán là khối liposarcoma trên cắt lớp vi tính. Bệnh nhân vào viện với triệu chứng lâm sàng không đặc hiệu, đã được chẩn đoán lại bằng MRI, sau đó được tiến hành phẫu thuật nội soi cắt bỏ hoàn toàn khối u nang bì buồng trứng. Tiếp cận chẩn đoán bằng nhiều trang thiết bị và đa chuyên khoa có thể giúp hạn chế được sự nhầm lẫn trong chẩn đoán.
KẾT QUẢ KỸ THUẬT CHỤP X-QUANG TỬ CUNG-VÒI TRỨNG BẰNG PHƯƠNG PHÁP HÚT CHÂN KHÔNG TẠI BỆNH VIỆN BẠCH MAI
Authors: Lưu Hồng Nhung , Vũ Đăng Lưu , Lại Thu Hương , Nguyễn Thị Thu Hà , Nguyễn Thị Huyền
Published: January 2025

Tổng quan: Theo Tổ chức Y tế Thế giới (WHO), vô sinh hiếm muộn là căn bệnh nguy hiểm thứ ba, đứng sau ung thư và bệnh tim mạch trong thế kỷ 21. Việt Nam là một trong những nước có tỉ lệ vô sinh cao trên thế giới. Chụp X-quang tử cung- vòi trứng(tên tiếng Anh là Hysterosalpinggraphy -HSG), được giới thiệu lần đầu tiên vào năm 1910. Mục đích của phương pháp là để đánh giá sự lưu thông của vòi trứng và đánh giá hình dạng, kích thước bên trong của tử cung- những yếu tố có thể dẫn đến vô sinh và các vấn đề khi mang thai. Chụp X-quang tử cung- vòi trứng bằng phương pháp hút chân không có nhiều ưu điểm so với phương pháp sử dụng kẹp Pozzi như giảm cảm giác đau, giảm nguy cơ chảy máu và nhiễm trùng sau thủ thuật. So với phương pháp Chụp X-quang tử cung- vòi trứng bằng bóng catheter thì phương pháp hút chân không dễ tiếp cận hơn, giá thành rẻ hơn.
Mục tiêu: Đánh giá kết quả kỹ thuật chụp X.quang tử cung vòi trứng bằng phương pháp hút chân không
Đối tượng và phương pháp nghiên cứu: Bao gồm tất cả các phụ nữ được chẩn đoán vô sinh và được chỉ định X-quang chụp tử cung-vòi trứng bằng phương pháp hút chân không tại Bệnh viện Bạch Mai năm 2021- 2024.
Kết quả: Nghiên cứu được tiến hành trên 178 bệnh nhân có 169 ca thực hiện thành công đạt tỷ lệ 94,9%. Phần lớn các ca được thực hiện trong thời gian ngắn dưới 10 phút đạt tỷ lệ 98,2%. Ca thực hiện nhanh nhất là 4 phút, lâu nhất là 12 phút. 29% bệnh nhân không có cảm giác đau khi thực hiện thủ thuật. Nhóm đau vừa và đau nhẹ chiếm lần lượt là 56,25 và 16,8%. Không có bệnh nhân nào nằm trong nhóm đau nhiều và đau không chịu nổi. Chỉ có 13 bệnh nhân chiếm 7,7% có biến chứng chảy máu nhẹ sau khi làm thủ thuật và tự cầm sau đó. 7 bệnh nhân có biến chứng nhiễm trùng biểu hiện là khí hư có mùi hôi chiếm 4,1%. Không có bệnh nhân nào bị sốt, bị dị ứng thuốc hay thủng tử cung vòi trứng khi làm thủ thuật. 79,3% các trường hợp sẵn sàng chụp HSG theo phương pháp hút chân không nếu được chỉ định ở lần tiếp theo.
Kết luận: Chụp X-quang tử cung-vòi trứng bằng phương pháp hút chân không với kỹ thuật thực hiện đơn giản, giá thành rẻ có tỷ lệ thành công cao, thời gian thực hiện ngắn, làm giảm cảm giác đau và các biến chứng chảy máu, nhiễm trùng cho bệnh nhân. Chụp X-quang tử cung-vòi trứng bằng phương pháp hút chân không nên được áp dụng rộng rãi hơn ở các cơ sở y tế trong chẩn đoán nguyên nhân vô sinh nữ.
KẾT QUẢ ĐIỀU TRỊ UNG THƯ TUYẾN GIÁP THỂ BIỆT HÓA DI CĂN PHỔI BẰNG I-131 TẠI BỆNH VIỆN UNG BƯỚU NGHỆ AN
Authors: Nguyễn Văn Hội , Mai Trọng Khoa , Mai Hồng Sơn , Nguyễn Ngọc Thắng
Published: January 2025

Mục tiêu: Đánh giá kết quả điều trị ung thư tuyến giáp thể biệt hóa di căn phổi điều trị I-131 tại Bệnh viện Ung bướu Nghệ An. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả hồi cứu kết hợp tiến cứu 45 bệnh nhân ung thư tuyến giáp thể biệt hóa di căn phổi được chẩn đoán bằng xạ hình toàn thân và đánh giá kết quả điều trị bằng I-131 tại khoa Y học hạt nhân, bệnh viện Ung bướu Nghệ An từ tháng 1/2018 đến 5/2024. Kết quả: Bệnh nhân UTTG thể biệt hóa di căn phổi có tuổi trung bình là 47,26 ± 15,75 tuổi, tỷ lệ nam nữ là 1/2,5. Thể giải phẫu bệnh chiếm chủ yếu là thể nhú với tỷ lệ 93,3%. Thyroglobulin lúc ngừng thuốc trung bình là 112,32 ± 154,7 ng/ml. Tổn thương trên xạ hình toàn thân với I-131 chủ yếu dạng tăng hoạt tính phóng xạ lan tỏa với tỷ lệ 77,8%. Bệnh nhân được điều trị nhiều lần với I-131, trung bình 3,75 lần và có tổng liều điều trị tích lũy 540 ± 193,73 mCi (150-970). Tỷ lệ đáp ứng hoàn toàn với I-131 chiếm 17,8%. Tỷ lệ đáp ứng không hoàn toàn và không xác định lần lượt là 64,44%, 17,8%. Tuổi và thyroglobulin kích thích là hai yếu tố có giá trị trong tiên lượng với đáp ứng điều trị I-131 ở bệnh nhân UTTG thể biệt hóa di căn phổi. Kết luận: Bệnh nhân UTTG thể biệt hóa di căn phổi được điều trị I-131 taị bệnh viện Ung bướu Nghệ An có tỷ lệ đáp ứng hoàn toàn là 17,8, tỷ lệ đáp ứng không hoàn toàn, không xác định lần lượt là 64,44% và 17,8%.
KẾT QUẢ ĐIỀU TRỊ SUY TĨNH MẠCH HIỂN LỚN BẰNG LASER 2 VÒNG NĂNG LƯƠNG ELVES RADIAL 2 RING TẠI BỆNH VIỆN ĐA KHOA TỈNH THANH HÓA
Authors: Nguyễn Hoàng Sâm , Đinh Văn Hạnh , Trần Bui khoa , Nguyen Van Ngoc
Published: January 2025

Mục tiêu: Nghiên cứu này nhằm đánh giá đặc điểm lâm sàng và siêu âm Doppler trước, sau điều trị suy giãn tĩnh mạch hiển lớn bằng Laser 2 vòng năng lượng ELVES Radial 2 Ring tại khoa chẩn đoán hình ảnh bệnh viện đa khoa tỉnh Thanh Hóa.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu can thiệp không đối chứng 18 tĩnh mạch hiển lớn được chẩn đoán suy tĩnh mạch trên siêu âm, được chỉ định đốt nội mạch bằng sóng cao tần RFA từ 10/2023 đến 11/2024.
Kết quả: Trong tổng số 18 tĩnh mạch được can thiệp. Tỷ lệ suy tĩnh mạch hai bên chân không có sự khác biệt có ý nghĩa thống kê với p, 0,05. Trước can thiệp: Đường kính tĩnh mạch hiển lớn đoạn giữa đùi trung bình 6,7±2,0mm, thời gian trào ngược đoạn giữa đùi 2051±969,3 ms ( lớn hơn 0,5 s). Sau can thiệp: Thân TM hiển lớn tắc hoàn toàn sau 1 tháng ( n=18 ), sau 1 tháng ( n=18), sau 3 tháng ( n=16) và 6 tháng ( n=13).
Kết luận: Tĩnh mạch hiển lớn bị suy có đường kính trung bình > 5mm với thời gian dòng trào ngược > 0,5s. Sau đốt Laser 2 vòng năng lượng ELVES Radial 2 Ring 6 tháng, thân TM bị tắc hoàn toàn với tỷ lệ 100 % (n=13).
Từ khóa: Suy tĩnh mạch hiển lớn, đặc điểm hình ảnh, lâm sàng, siêu âm Doppler, Elves Radial 2 ring.
ĐỒNG THUẬN CHUYÊN GIA VỀ ĐIỀU TRỊ UNG THƯ BIỂU MÔ TẾ BÀO GAN BẰNG PHƯƠNG PHÁP TẮC MẠCH HÓA CHẤT ĐƯỜNG ĐỘNG MẠCH
Authors: Vũ Đăng Lưu , Phạm Minh Thông , Nguyễn Tiến Thịnh , Đỗ Đăng Tân , Lê Thanh Dũng , Lê Trọng Bỉnh , Lê Văn Khảng , Nguyễn Đình Luân , Nguyễn Ngọc Tráng , Ngô Lê Lâm , Trịnh Hà Châu , Thân Văn Sỹ , Nguyễn Duy Anh , Lê Đức Thọ , Trần Đức Huy , Phạm Quang Sơn , Lê Doãn Trí , Phạm Cẩm Phương , Phan Thị Hồng Đức , Hồ Tấn Phát , Nguyễn Ngọc Cương , Võ Duy Thông
Published: January 2025

Nội dung các khuyến cáo của các chuyên gia về các vấn đề liên quan đến phương pháp tắc mạch hóa chất trong điều trị ung thư biểu mô tế bào gan như : phương pháp chẩn đoán hình ảnh sử dụng trước điều trị; lựa chọn bệnh nhân, đường tiếp cận và các công cụ hỗ trợ, kỹ thuật điều trị; vật liệu tắc mạch và các hóa chất sử dụng; theo dõi sau điều trị; kết hợp các phương pháp điều trị khác.
Migration and the elderly: Analyzing the social challenges of families left behind
Authors: Rahmanova Gulchehra , Davlatova Khulkaroy , Shahabitdinova Shohida , Odiljonova Aziza , Khayitova Shakhnoza , Akhunov Mukimjon
Published: January 2025

Migration has emerged as one of the most transformative global phenomena of the 21st century, reshaping not only economies but also family structures and social dynamics. While much attention has been paid to the economic and labor market impacts of migration, far less is known about the effects on families left behind, particularly the elderly. This article delves into the myriad social challenges faced by elderly individuals whose children have migrated, often leaving them behind in vulnerable situations. These elderly parents, separated from their primary caregivers, frequently confront issues such as social isolation, emotional distress, financial instability, and disrupted family roles. Drawing from multiple disciplines—including sociology, economics, and gerontology—this article analyzes the intersection of migration and aging, with a particular focus on how migration-induced changes in family structure affect the elderly. Additionally, the paper explores the potential role of policy interventions and community-based solutions to mitigate these challenges. Ultimately, the study seeks to offer a comprehensive understanding of the social and emotional repercussions of migration on the elderly population, while providing recommendations to address these pressing issues in the context of modern global migration patterns.