bluuebunny/crossref_metadata_2025 huggingface dataset:
Biodegradation of malachite degradation by laccsae from Bacillus licheniformis NS2324
Authors: Chopra Navleen Kaur , Sondhi Sonica
Published: May 2022

Malachite green, a triphenylmethane dye, is used in aquaculture to limit the growth of protozoans and fungi in fish. It is also employed in the food, medicinal, and textile sectors. MG has high toxicity covering micro organisms and higher eukaryotes. Its toxic effects include organ damage, developmental abnormalities and mutagenic/carcinogenic potentials. Hence it is of utmost importance to degrade MG. Therefore, in this study with the help of catalytic properties of laccase, biodegradation of dye-malachite green was studied with respect to different factors like temperature, pH, enzyme dose and treatment time. The maximum of 99.31±0.97%  MG decoloration was obtained under the conditions of 10 U ml-1 enzyme, pH 8.0 incubation time 1h and a temperature of 50°C. MG was degraded without any mediator of laccase in the current study.
Pharmaceutical potential of active compounds from plants
Authors: Muneeswari Muniyasamy , Reddy Gangasani Narasimha , Arivukodi Deivasigamani , Usharani Boopathy , Shobana Chandrasekar
Published: May 2022

Alzheimer's illness (AD) is an issue that causes cell degeneration in the cerebrum and is the primary driver of dementia, which is described by a lessening in thought and freedom in private everyday exercises. Promotion is viewed as a multifactorial sickness: two primary speculations were proposed as a reason for theories of commercials, cholinergic and amyloids. Moreover, a few gamble factors, like expanding age, hereditary variables, head wounds, vascular illnesses, contaminations, and natural elements, assume a part in the infection. At present, there are just two sorts of meds endorsed to treat AD, including cholinesterase compound inhibitors and N-methyl D-aspartate (NMDA) bad guys, who are powerful just in the treatment of AD side effects, yet don't fix or keep you from disease. Today, research is zeroing in on the comprehension of AD pathology focused on a few systems, like strange tau protein digestion, β-amyloid, fiery reaction, and cholinergic and free extreme harm, with the target of creating effective medicines to stop or alter the course of the declaration. This survey presently examines accessible drugs and future hypotheses for the advancement of new treatments for AD and normal mixtures.
Determination of antihyperglycemic activity of ethanolic crude leaf extract of cassia auriculata in the streptozocin induced male wistar albino rats
Authors: Shanmugam Hemalatha , Venkatesan Rantham Subramaniam
Published: May 2022

Cassia auriculata is used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on determination of antihyperglycemic activity of ethanolic crude leaf extract of cassia auriculata (CA) in the streptozocin induced male wistar albino rats. A single dose of (45mg/kg of body weight/day) STZ was administered to induce diabetes and the effect of ethanolic leaf extract of cassia auriculata on STZ induced diabetes were assessed based on glucose, plasma insulin, creatinine and urea, serum lipid profile, serum protein, albumin, globulin, serum Transminases and Alkaline phosphatase (ALP)] analysis.The ethanol extract of CA leaf elicited significant reductions in the STZ induced elevation in the biochemical markers. From the above results, it is concluded that ethanolic leaf extract of CA possesses significant antihyperglycemic effects in STZ induced diabetic rats.
Towards better intelligent implementation of Schizophrenia prediction using federated deep learning framework
Authors: Menon Niharika G. , Bhavana N. D. , Hema D. Deva
Published: May 2022

Early detection of individuals susceptible to Schizophrenia (SZ) is critical for early intervention, which can reduce the risk of psychosis. This research proposes a deep learning method for classifying EEG data by picking important discriminative EEG features. While existing systems employ an R-CNN methodology, we propose a hybrid CNN–Bi- LSTM automated system that analyses EEG statistical data and performs the prediction. It uses a CNN for an optimised feature selection process to select the most important and informative features, with Bi-LSTM for prediction of susceptibility to develop SZ. The model when run on EEG data of schizophrenic paradigms gives output as ”Schizophrenic” or ”Non-schizophrenic”. This method has a high level of classification accuracy when compared to most existing machine learning models. While it displays a lower accuracy than some complex deep learning systems, it is much more stable and easy to interpret and thus is more practical for clinical settings.
Efectos mediadores de la orientación estratégica en la relación capacidad de aprendizaje organizativo y desempeño innovador: Un estudio exploratorio en Mipymes
Authors: Brenes Sánchez Ronald , Mora Esquivel Ronald , Gutiérrez Montoya Guillermo Antonio
Published: May 2022

El propósito del estudio es evaluar el efecto de mediación de la orientación estratégica OES en la relación capacidad de aprendizaje organizacional CAO y el desempeño innovador DI en micros, pequeñas y medianas empresas (Mipymes). El diseño metodológico se basó en un análisis de regresión jerárquica a partir de una muestra de 162 Mipymes en Costa Rica obtenidas por medio de un instrumento aplicado a propietarios, gerentes y encargados de las empresas. Los resultados evidencian que el desempeño innovador es influido positivamente cuando las mipymes aprovechan su capacidad de aprendizaje organizativo e integran en su funcionamiento dimensiones como la exploración, el amortiguar el riesgo, el contacto con el entorno y un diálogo y participación de sus miembros. De igual forma se releva que la orientación estratégica seguida por las mipymes, ya sea proactiva, analizadora o defensora es un determinante significativo en esta relación.
Crisis sociocultural, justicia contextual y pensamiento crítico latinoamericano
Authors: Salas Astrain Ricardo , Sandoval Tapia Felipe
Published: May 2022

En dos libros publicados este año 2020 y titulados respectivamente: Evadir. La filosofía frente a la protesta social y Luchas Sociales, Justicia contextualizada y Dignidad de los pueblos aludimos en su introducción a una comprensión sociohistórica y política de los contextos chileno y latinoamericanos en que surgieron las protestas y luchas de movimientos sociales y pueblos frente a las múltiples injusticias, inequidades y exclusiones que les afectan. La hipótesis general es que, en el año 2019 nos encontrábamos frente a una crisis social producto del deterioro creciente de los espacios democráticos, ligada al atropello creciente de los derechos económico-sociales de las mayorías, producto de la ideología neoliberalista. En este contexto, la nueva crisis biopolítica que agrega la expansión de Covid-19, que irrumpe por el planeta en estos últimos meses mostrando las contradicciones entre países, regiones y territorios, permite mostrar que el fenómeno de la crisis es mucho más complejo, ya que asume la forma de una pandemia que afecta tanto al modelo económico como a un tipo de civilización global, y que se trasluce en el avance del contagio, no sólo de un virus, sino de la inhumanidad en las relaciones nacionales e internacionales. A pesar que el panorama es incierto, a partir de algunos datos que extraemos de lo que nos acontece en estos últimos tiempos, pretendemos delinear un pensar político que da cuenta de ciertos aprendizajes políticos actuales que devuelva la dignidad de la ética y de la política en el espacio social. . Para ello, haremos un camino argumentativo en dos etapas: una primera etapa, que precisa ciertas cuestiones teóricas ligadas a los contextos de la justicia; y una segunda, que entrega un panorama acerca de las luchas sociales latinoamericanas que cuestionan las políticas neoliberales y las democracias postdictaduras.
Editorial
Authors: Grenni Héctor
Published: May 2022

Este número 40 de Teoría y Praxis ve la luz en tiempos de pandemia, todavía. El número 40 desde el nacimiento de Teoría y Praxis, allá por el año 2002, y el tercero en tiempos de pandemia.
protesta social durante el Gobierno de Mauricio Funes-FMLN
Authors: Ramos Vidal Sandra Vanessa
Published: May 2022

Este artículo analiza las principales protestas ocurridas durante el Gobierno efemelenista de Mauricio Funes y cómo éste respondió a las movilizaciones colectivas, ya que se identificaron pequeños picos de protestas. El análisis se centra en la protesta social y en algunas de sus variables clave como el conflictograma, los repertorios de acción colectiva, los actores demandantes y demandados, la zona geográfica del conflicto, los campos de conflictividad, las demandas, los procesos enmarcadores, la radicalidad y los picos de la protesta, y la respuesta del Gobierno. El estudio se realizó a través de métodos cualitativos y cuantitativos. Como resultado principal se identificó que las protestas buscaron mejorar las condiciones de existencia y el funcionamiento institucional y que el Gobierno respondió a las movilizaciones con rechazo y estableciendo una mesa de diálogo con algunos actores claves.
paradigma tecnocrático
Authors: Navarro Camacho Marianela , Mena León Carlos Luis
Published: May 2022

Este artículo presenta un análisis del paradigma tecnocrático para comprender cómo este jerarquiza el conocimiento, legitima el poder y establece un orden lineal de desarrollo. Se inicia el análisis con el concepto de tecnología referido a un saber – hacer que permite el surgimiento de la civilización. Esto, para comprender como la tecnocracia se consolida como ideología con un ethos penetrante que impone cierta visión de mundo y tiene implicaciones en lo político, económico, social y ambiental que evidencia la necesidad de superar el determinismo tecnológico en procura del bien común.
Traumatic Membranous Urethra Rupture in a Foal: A Case Report
Authors: Akın İbrahim , Bellek Cahit Gürsel , Bulut Burak , Kılıç Nuh , Özturan Yalçın Alper
Published: May 2022

Urethral ruptures can be a life-threatening emergency that may lead to uroperitoneum. Uroperitoneum can result from urethral ruptures, which can be fatal. This case report aimed to describe the clinical findings and treatment outcomes of a traumatic membranous urethral rupture in a 15-day-old Ambling foal. The foal had been wounded by a wild animal 9 days prior, and despite treatment, the foal's condition worsened, the owner brought the animal to the Faculty of Veterinary Medicine Research and Practice Animal Hospital. On physical examination several wounds in the pubic and inguinal regions were identified, some of which were complicated by a fistula. The rectal body temperature, heart rate, respiration rate, and capillary refill time were low. In laboratory findings, lymphopenia, eosinopenia, and mild anemia decreased partial oxygen pressure with acidic blood pH were observed. Sutures were applied to the urethral tear and wound care was provided. On the fifth day after surgery, the owner called the hospital to report that the foal was constipated and had signs of colic. Rectal olive oil use was recommended, and surgery was arranged for the following day. Despite cardiac resuscitation and emergency treatments, the foal couldn’t be saved during the operation due to cardiac arrest. In conclusion, even for unrelated surgical operations involving the gastrointestinal system, gastrointestinal outcomes of surgery and anesthesia must be considered.
Zonificación del peligro de licuefacción en la provincia de Guantánamo, Cuba
Authors: Mojena Guillermo Lemes , Diéguez Liuska Fernández , Echavarría Fernando Guasch , Basquerote Adilson Tadeu , Menezes Eduardo Pimentel
Published: May 2022

La licuefacción de suelos como fenómeno inducido por terremoto de gran magnitud no ha sido reportada en la provincia de Guantánamo, la probabilidad de ocurrencia de potentes movimientos telúricos al Sur de la región oriental de Cuba con referencia en la zona sismo generadora Battler – Caimán unido a espacios con condiciones litológicas e hidrogeológicas favorables permite la visualización de territorios susceptibles a este proceso. El presente trabajo pretende dar a conocer las zonas con peligro de licuefacción en Guantánamo, como cuestión necesaria para el proceso ordenamiento territorial y para la gestión de riesgo de desastre por esta causa, se empleó el método de superposición de mapas temáticos de los componentes, geólogo – tectónica, relieve, suelo e hidrogeológico, para lo cual se utilizó la herramienta ArcGIS 10.2, los resultados se corroboraron con el trabajo de campo.
A Post-German City as a Palimpsest in Contemporary Prose of the Lubuskie Land
Authors: Gieba Kamila
Published: May 2022

The article concerns contemporary Polish literature about post-war migrations caused by the change of the border between Poland and Germany in 1945. The main topic of this article is the literary representation of a post-German city. Selected works by three authors associated with the Lubuskie Land are analyzed. They are: the novels Grünberg [Green town] by Krzysztof Fedorowicz, Stacyjka na wschodzie i zachodzie [The train station in the east and in the west], and Klucze do rzeki [Keys to the river] by Maria Sidorska-Ryczkowska; and a volume of poetry by Janusz Werstler, Ocalone w słowie: Odejście Marii, odejście Anny [Survived in a word: Maria's departure, Anna's departure]. The decision to focus on Lubuskie-themed works has been prompted by a shortage of scholarly studies of the literature of this region in comparison with literary studies on other regions of an area known as the Regained Territories. The interpretation of the images of the post-German city is based mainly on the palimpsest category.
The Presence of Pangolin through Camera Trap Assessment in Ratnagiri District of Northern Western Ghat of Maharashtra, India
Authors: Katdare Bhau , Singh Abhishek , More Pratik , Ghorpade Soham
Published: May 2022

Manis crassicaudata (Indian Pangolin), distribution and natural history are poorly known in India. There is much worry regarding the regarding the conservation status of this species across the nation and globe. Pangolins are threatened due to habitat loss and illegal wildlife trade and are highly trafficked mammals in the world. It is essential to understand ecology and distribution of the species and streamline specific species conservation action plan. Sahyadri Nisarga Mitra (SNM) with the support of the forest department and local bodies carried out camera trap assessment to study the presence of the species in Northern Western Ghat of Ratnagiri district, Maharashtra, India. The baseline data derived through local interviews, Traditional knowledge of indigenous communities was used to track species burrows and conduct transect survey. In the present study 36 Camera trap were deployed to document the presence of the species across the region. Camera traps resulted in 1.7% success rate and documented 192 photos and 49 videos of Pangolin activity.
LEITURA DE IMAGEM INTERDISCIPLINAR – MONTAGEM DE FOTOS DO SOL EM DIFERENTES COMPRIMENTOS DE ONDA
Authors: Augusta Diniz Telma , Corci Batista Michel
Published: May 2022

Este texto propõe analisar a utilização de uma imagem do Sol em diferentes comprimentos de onda, delimitando o estudo para a área do Ensino da Astronomia, visto que esse conteúdo desperta o interesse dos alunos e, quando associada ao uso de imagens, os influencia no processo de aprendizagem.
LEITURA DE IMAGEM INTERDISCIPLINAR COM ENFOQUE CTS (CIÊNCIA/ TECNOLOGIA/SOCIEDADE) – RELEITURA DA OBRA OPERÁRIOS DE TARSILA DO AMARAL
Authors: Mendes Ferreira Fernanda , Francine Machado Daniele , Rodrigues Jagas Neves Izauriane , Maria Lopes Jordana
Published: May 2022

A leitura de imagens é uma prática constante em nosso dia a dia, mas que nem sempre vem atribuída a uma análise mais ampla e detalhada. Para tanto, Santaella (2012) define que o leitor é todo aquele que além da leitura escrita, também tem a capacidade de ler imagens e assim não se limita apenas em decifrar letras, estabelecendo relações entre a imagem e a escrita. A partir disso, Santaella (2012) define vários tipos de leitores para várias formas de imagens, ao refletir sobre as imagens que nos cercam, tais como: os sinais e signos que observamos nas ruas da cidade, presentes no trânsito, placas de localização, semáforos, bem como nos televisores, cinema, vídeo, internet, fotografia, desenho, esculturas, pinturas, gráficos, mapas, entre outros.
LEITURA DE IMAGEM INTERDISCIPLINAR – MODELO DE CÉLULA ANIMAL
Authors: Chefer Claudiane
Published: May 2022

O ensino de ciências e de Biologia apresenta inúmeros conceitos abstratos de difícil compreensão, o que pode dificultar o trabalho dos(as) professores(as) e fortalecer as ideias nas quais os saberes produzidos pela ciência são dificilmente entendidos pelos estudantes. Neste cenário, as imagens, devido a seu valor cognitivo e apelo visual, são consideradas importantes recursos didáticos que, a partir da representação de modelos da ciência, podem auxiliar na apropriação da linguagem científica e oferecer potencial para facilitar a compreensão da ideia e a identificação das estruturas, conceitos e fenômenos nela representados (PICCININI; MARTINS, 2004; GOUVÊA; MARTINS, 2001).
IMAGENS DO BRASIL: A FOTOGRAFIA NA RELAÇÃO ARTE E CIÊNCIA
Authors: Silva Junior Nelson
Published: May 2022

É por meio das imagens que alcançamos não os lugares ou pessoas, mas sim conceitos desses lugares ou dessas pessoas, o que nos permite elaborar formas variadas de apreciação, fruição ou interação com o universo das imagens retratadas. Refletir, ainda que minimamente, sobre a Fotografia e o seu papel social se torna essencial antes de apresentarmos este ensaio. A inserção maciça dos smartphones, junto às sociedades do século XXI, trouxeram para o campo da Fotografia infindáveis possibilidades de produção e, consequente, apreciação.
LEITURA DE IMAGEM INTERDISCIPLINAR – FITA DE MOEBIUS II
Authors: Gonzales Jolandek Emilly
Published: May 2022

A obra Fita de Moebius II, escolhida para esta análise, é uma xilogravura de Maurits Cornelis Escher. A escolha do autor, e desta obra, se deu pelo fato de grande parte de suas obras estarem relacionadas à Matemática e diversos conteúdos da área. Como já foram desenvolvidos, em sala de aula, atividades e pesquisas com alunos, envolvendo as obras de Escher, optou-se por selecionar esta obra específica. Esta imagem chamou atenção, pois na Matemática há uma teoria por trás da Fita de Moebius/Möbius, além disso, no pensamento Matemático também está presente o conceito de infinito.
Analysis of Search and Rescue Tactics in Single-Story Single-Family Homes Part III: Tactical Considerations
Authors:   UL's Fire Safety Research Institute, Weinschenk Craig , Stakes Keith
Published: May 2022

Prior full-scale fire service research on the residential fireground has focused the impact of ventilation and suppression tactics on fire dynamics. This study builds upon prior research by conducting 21 experiments in two identical purpose-built single-story, single-family residential structures to quantify the impact of how search and rescue tactics are coupled with ventilation and suppression actions and timing. Each fully furnished structure included four bedrooms, 2 bathrooms and an open-floor kitchen and living room. The structures were instrumented to quantify post-ignition toxic gas and thermal conditions. Temperature, velocity, and pressure were measured to evaluate the fire dynamics. Gas concentrations and heat fluxes were measured to quantify toxic and thermal exposures. Eleven experiments examined bedroom fires, eight examined kitchen fires, and two examined living room fires. Across this series of experiments, the impact of isolation of fire and non-fire compartments, the timing of search actions relative to suppression actions, and the influence of isolation, elevation, and path of travel during rescue were examined with respect to firefighter safety and occupant tenability. Similar to previous experiments in both purpose-built and acquired structure, the data showed that prior intervention locations lower in elevation and/or behind closed doors had lower toxic gas and thermal exposures compared to locations at higher elevations or locations that were not isolated. Lower elevations were also shown to have lower toxic gas and thermal exposures during the removal of occupants as part of rescue operations. For scenarios where search operations occurred prior to suppression, isolation of spaces from flow paths connected to the fire compartment was shown to be effective at reducing the thermal operating class for firefighters and the toxic and thermal exposure rates compared to spaces that were not isolated. Following isolation, exterior ventilation was found to further reduce the toxic gas and thermal exposures in the protected space. Suppression, from either interior and exterior positions, was effective at reducing the thermal operating class for searching firefighters and the rate of thermal exposure increase to occupants. Following suppression, additional exterior ventilation increased the rate at which gas concentrations returned to pre-ignition levels.
A new Rectolejeunea from Indian Botanic Garden, India
Authors: Singh S.
Published: May 2022

Rectolejeunea devendrae Sushil K.Singh, closely related to R. olivacea (Steph.) S.C. Srivast. and A. Agarwal, is described as a new species from Indian Botanic Garden, Howrah in Gangetic plains of West Bengal, India.
Nhu cầu chăm sóc giảm nhẹ của người bệnh ung thư tại trung tâm ung bướu, Bệnh viện Trung ương Thái Nguyên và một số yếu tố liên quan
Authors: Vũ Đình Sơn , Phạm Ngọc Ánh , Đặng Thị Vân Anh , Lê Thúy Phượng
Published: May 2022

Mục tiêu: Mô tả thực trạng và xác định một số yếu tố liên quan đến nhu cầu chăm sóc giảm nhẹ của người bệnhung thư tại Trung tâm Ung bướu, Bệnh viện Trung ương Thái Nguyên năm 2021.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 190 người bệnh ung thư từ 18 tuổi trở lên và điều trị nội trú từ tháng 12/2020 đến tháng 6/2021.
Kết quả: Tỷ lệ người bệnh có nhu cầu chăm sóc giảm nhẹ chiếm 66,3%. Trong đó, 3 nhóm nhu cầu có tỷ lệ cần hỗ trợ cao nhất là: nhu cầu hỗ trợ thông tin y tế, nhu cầu hỗ trợ tài chính và phúc lợi xã hội và nhu cầu hỗ trợ thể chất. Có mối liên quan giữanhu cầu chăm sóc giảm nhẹ với giai đoạn bệnh và nghề nghiệp của người bệnh ung thư. Nhóm người bệnh ở giai đoạn III và IV có nhu cầu chăm sóc giảm nhẹ cao hơn gấp 1,63 lần) so với nhóm người bệnh ở giai đoạn I, II (p < 0,05; 95%CI: 1,15 – 2,32). Người bệnh làm nghề nông có nhu cầu chăm sóc giảm nhẹ cao hơn gấp 3,17 lần so với người bệnh đã nghỉ hưu (p<0,05; 95%CI: 1,43 – 7,07).
Kết luận: Đa số người bệnh ung thư  có nhu cầu chăm sóc giảm nhẹ. Nhu cầu chăm sóc giảm nhẹ của người bệnh ung thư có mối liên quan đến giai đoạn bệnh và nghề nghiệp của người bệnh.
ФОРМУВАННЯ ЕМОЦІЙНОГО ІНТЕЛЕКТУ В УЧНІВ ПОЧАТКОВОЇ ШКОЛИ: ТЕОРІЯ І ПРАКТИКА
Authors: Чекановська Ірина
Published: May 2022

У статті розглянуто формування емоційного інтелекту дітей молодшого шкільного віку в умовах становлення Нової української школи. Здійснено аналіз наукових, методичних праць, проаналізовано сучасний підхід до вивчення та визначення емоційного інтелекту, запропоновано його власне бачення. Здійснено акцент на важливості поєднання емоційного й інтелектуального аспектів. Висвітлено специфіку поділу ЕІ на його складові , уточнені їхні переваги й недоліки. За результатами дослідження уточнено поняття «емоційний інтелект». Установлено, що перша взаємодія з навколишнім світом у дитини відбувається через емоції. Розумовий розвиток малечі в подальшому будується за допомогою цих зв’язків. Також комфортне існування в соціумі залежить від уміння виявляти свої емоції, контролювати негатив, визначати емоції інших та виказувати емпатію. Сформульовано рекомендації для вчителів початкових класів та батьків із формування емоційного інтелекту. Розроблено добірку завдань, ігор, вправ і бесід для роботи з учнями 1–2 класів із метою формування ЕІ молодших школярів з урахуванням положень концепції Нової української школи. Продемонстровано досвід роботи над формуванням емоційного інтелекту в учнів молодшого шкільного віку. Розкрито результати експериментального навчання учнів початкових класів із використанням вправ та ігор. Матеріали статті стануть у пригоді вчителям початкових класів під час проведення уроків української мови та інтегрованого курсу «Я досліджую світ». Подана добірка вправ, бесід та ігор, які можна використати в ході проведення ранкових зустрічей, на перервах, хвилинках відпочинку. Надано рекомендації батькам із формування емоційного інтелекту в учнів початкової школи.
СТВОРЕННЯ ІНФОГРАФІКИ В СЕРВІСІ «CANVA ДЛЯ НАВЧАННЯ»
Authors: Шевченко Ганна
Published: May 2022

У статті розглянуто поняття інфографіки, її переваги для навчання і варіанти застосування на шкільних уроках. Також подано опис сервісу «Canva для навчання» як ефективного засобу для створення різноманітних дизайн-проєктів, зокрема інфографіки. Докладно описано процес реєстрації та особливості переходу від базового плану Canva до безкоштовної освітньої версії. Розглянуто процес створення інфографіки у сервісі «Canva для навчання» від вибору шаблону і до публікації або завантаження готового продукту.
Controversial Impact of Hepcidin Metabolism in the Pathogenesis of Anemia in Myelofibrosis
Authors:   Clinic of Hematology, UMHAT “Sveta Marina”, Medical University, Varna, Bulgaria, Dimitrova Stela , Gercheva Liana , Gerova Daniela , Micheva Ilina
Published: May 2022

Anemia in myelofibrosis (MF) is a result of a multifactorial process, which is incompletely understood. The central pathogenetic mechanism is a replacement of normal hemopoietic tissue by fibrotic stroma. However, ineffective erythropoiesis, inflammation and iron overload have an additional impact on anemia development, suggesting the role of dysregulated iron homeostasis and hepcidin. The aim of the study was to analyze parameters of iron metabolism and inflammation in patients with different forms and stages of myelofibrosis. Thirty-six patients with primary MF, post-polycythemia vera and post-essential thrombocythemia MF and fourteen healthy controls were included in the study. In the patient group, serum ferritin, Fe, TIBC and parameters of CBC were measured as a part of routine clinical assessment. Plasma total hepcidin levels and concentrations of Interleukin-6 (IL6) and Interleukin-8 (IL8) were measured in duplicate by ELISA (My BioSource, San Diego, USA) in patients and healthy controls. The hepcidin level in the patient group was found statistically lower compared to healthy controls (27,64±41,56 ng/ml; 111,13±49,56 ng/ml; F=2,81, p<0,001). Patients with newly diagnosed MF had significantly higher levels of hepcidin compared to those with prolonged evolution: between 1 and 5 years (p=0,005) and >5 years (p=0,038). Transfusion dependent patients presented with lower hepcidin compared to transfusions independent (10,10±6,67 ng/ml; 31,15±44,37 ng/ml; p=0,026). In patients receiving cytoreductive or target treatment hepcidin level was significantly lower compared to patients on best supportive care (17,74±21,99 ng/ml; 43,05±58,46 ng/ml; p=0,037). No difference was found in hepcidin level within the risk groups according to DIPSS, neither between the subtypes of disease (primary MF and secondary MF). Higher hepcidin positively correlated with leukocytosis (R=0,665, p=0,009) and age (R=0,392, p=0,0081). By multivariate analysis, a significant highly positive correlation was found between hepcidin and IL-6 (R=0,535, p=0,002) and weaker between hepcidin and IL-8 (R=0,413, p=0,21) A significant straight correlation was demonstrated between IL-6 and IL-8 (R=0,464, p=0,009) and a negative between serum iron and IL-6 (R=-0,367, p=0,42) and IL-8 (R=-0,438, p=0,14), respectively. The hepcidin regulation is complex and multifactorial. Its role in pathogenesis of anemia in myelofibrosis is controversary. Probably it has a higher impact in early stages of the disease and depends on treatment and transfusions.
Làm Thế Nào Giữ Được Tuổi Xuân Trong Trắng?
Authors: Võ Tá Đương
Published: May 2022

Người ta vẫn thường nói rằng: thanh xuân, tuổi trẻ là khoảng thời gian đẹp đẽ và rực rỡ nhất trong cuộc đời của mỗi con người. Bởi vì, tuổi trẻ là những năm tháng mà con người ta căng tràn sức sống mãnh nhiệt và cháy bỏng với những khát khao, những hoài bão về một tương lai rạng ngời, những ước vọng dấn thân trên con đường công danh sự nghiệp của cả đời người. Bất cứ dân tộc nào, ở thời đại nào, vai trò của người trẻ cũng được đề cao và được mọi người quan tâm để ý, vì ở độ tuổi đó, họ có khả năng “dời non, lấp biển”, là trụ cột của đất nước và tương lai của Giáo Hội.
Abstract
There is a common belief that youth is the most beautiful and dazzling period in a person's life. Because youth is a time when individuals are filled with passionate and burning energy, dreams for a bright future, and a desire to dedicate themselves to the road of fame and success. Young people have the power to "remove the mountains and fill the sea" as the future of the nation and the Church, regardless of ethnicity or time period.
Jesus’ Praying Model
Authors: Phạm Vũ Phi Hổ
Published: May 2022

Prayer has always been an important daily activity in the lives of Christians. If people do not pray, it is very easy to fall into the temptations of the devil, and fall away. Jesus in the Garden of Olives reminded his disciples to watch and pray so as not to be far from temptation (Luke, 2022) (Luke 22:46). The Church has always taught us to 'pray like breaths or heartbeats' every day (Francis, 2021) (Nguyễn, 2020). This shows the special importance of prayer. However, not everyone knows how to pray properly, because sometimes we just know how to 'beg' rather than pray. Although asking is also a form of prayer, it seems to only go one way from man to God, without knowing what God's will is every time we ask. This article will present a model of prayer that is very pleasing to God, because this model of prayer is a model drawn from Jesus' sincere prayer when he prayed most urgently, before when entering torture.
Lạy Chúa, Con Phải Làm Gì?
Authors: Võ Tá Đương
Published: May 2022

Sinh ra và lớn lên trong cuộc đời này, ai cũng mong muốn cho mình có một cuộc sống an bình, vui tươi, hạnh phúc, và có ý nghĩa thật sự; ai cũng muốn một cuộc sống ngẩng cao đầu không hổ với người, không thẹn với lòng. Để đạt được mong muốn đó, con người ta phải nỗ lực cố gắng hết mình, ngang qua những chọn lựa trong cuộc sống; bởi lẽ, cuộc đời là những chọn lựa: chọn chỗ ở, chọn nghề nghiệp, chọn lý tưởng sống, chọn bạn bè, chọn bạn đời.
Abstract
Born and raised in this world, everyone desires a calm, joyous, happy, and purposeful existence; everyone wants to live with their heads held high, without being embarrassed of others or their emotions. To attain that goal, individuals must make the most of their choices in life, since life is about making decisions: selecting a location to live, a profession, an ideal life, friends, and a life partner.
The System Ergonomics and Usability as a Measurement of the Software Agents Impact to the Organization
Authors: Kopka Bartosz , Żytniewski Mariusz
Published: May 2022

The purpose of this article is to analyze the concept of ergonomics in theory of software agents and its use in the construction of agent systems that supports the knowledge based organizations. In particular, the study will be focused on testing methods in context ergonomics of the agent society and their use in the analysis of the impact of agents on the business processes in the organization. Modern organizations require knowledge-based construction solutions, which in conditions of pervasive communications will support the processes occurring in them. Such solutions can be software agents. However, to assess their impact, it is necessary to define metrics that would indicate how much software agents support organization. Undertaken research in this area indicates that various features of software agents cause that they should be treated on a higher level of abstraction compared to the currently used software solutions. One of the aspect that can be picked up is the area of the cognitive ergonomics. It focuses around mental processes such as perception, memory, reasoning, knowledge, and issues of human reliability and increasing human cognitive abilities. Cognitive Ergonomics can be seen in the context of the software agent interaction solutions for users. The implementation of the cognitive ergonomics in human-computer relationship can take place through the use of agent technologies, such as anthropomorphic agent-system. Available literature does not define sufficiently the construction methodologies of the agent systems in the context of the presented issues of cognitive ergonomics. As a result, it becomes necessary to undertake research in the field of ergonomics and evaluation of impact on users as well as business processes in which they participate.
Human vs. Machine in Life Science Automation: Comparing Effectiveness of Manual and Automated 3-D Cell Culturing Processes
Authors: Lehmanna Ricarda , Thurowa Kerstin , Stollb Regina , Weippertab Matthias
Published: May 2022

There is an ongoing shift from 2-D cell culturing to 3-D approaches, particularly because three dimensional cell cultures better simulate in vivo conditions. Thus, automation of 3-D culturing processes is a current issue in life science automation, as it is supposed to provide standard qualities and the potential of large-scaled production of 3-D tissues. In the traditional production process, human sensory-motor and evaluation skills are essential for successful 3-D cultivation. This study aimed to evaluate the effectiveness and efficiency of an semi-automated HeLa-cell culturing process compared to traditional manual processing. HeLa cells were manually and automatically encapsulated in alginate matrices and cultivated in media with (+P/S) and without antibiotic (-P/S). The manual steps were carried out by skilled laboratory staff. The automated procedures were performed by the Biomek® Cell Workstation. The proliferation rates and toxicities were evaluated on day 1, 14 and 35. Further, measurements of the duration of the processes and an expert interview as well as process observation of novice and expert staff have been carried out. The proliferation rates of manual produced alginate beads +P/S were significantly higher compared to the rates of the semi-automated produced beads. Average proliferation rates of the manually and semi-automatically produced alginate beads –P/S were similar on all post production days. Further, our results showed a significant increase of the cytotoxicity +P/S and –P/S from day 1 to day 35 for both types of production. On day 1, the cytotoxicity of manual produced beads was significantly higher compared to semi-automated produced beads. Particularly on day 35 toxicity of alginate beads +P/S was significantly increased compared to beads –P/S. Concluding, single process duration of the automated alginate bead production is higher and effectiveness and efficiency of the manual bead production is slightly worse compared to manual processing. However, the main benefits of automated processes are a stable quality, high reproducibility and increased absolute sample production (24/7-operation).
Anthropometric Consideration of Interior Design of City Buses
Authors: Zunjic Aleksandar , Sofijanic Evica Stojiljkovic Svetozar
Published: May 2022

There are numerous researches that are connected with designing of the bus driver's workplace. However, there is no a study that has been conducted in relation to the designing of the interior of city buses from the anthropometric aspect. It is noticeable the lack of existence of the methodology for collecting the relevant ergonomic data that can be used at the designing stage of buses for public transport of passengers. This article is primarily concerned with solving the problem of selection of relevant anthropometric dimensions that need to be considered when designing the city buses. On the basis of adopted criteria, certain number of relevant anthropometric dimensions is initially selected for designing the interior of buses. In addition, the initial methodological approach has been further improved by creating the new anthropometric dimensions (such is, for example, the comfortable grip height) that should be measured in connection with designing certain elements of the bus interior. These dimensions are named the comfortable anthropometric dimensions. For each new dimension, the measurement method is described. In addition, each dimension is associated with the function that it has in terms of designing and positioning of certain parts of the interior of the bus.
Pushing and Pulling Risk Assessment in Fiat Group Automobiles Industrial Reality: Methods to Analyze Critical Operative Conditions According to ISO 11228-2 Principles
Authors: Germanàa D. , Spadaa S. , Lombardib G. , Baraccoc A. , Coggiolac M. , Sessad F. , Ghibaudoa L.
Published: May 2022

The Italian legislation, D.Lgs 81/08, requires employer to make the assessment of every risk the worker is exposed to, including the risk of biomechanical overload of musculoskeletal structure due to Manual Material Handling. In particular, the Italian legislation recalls international ISO standard of 11228 series as reference to Manual Material Handling risk assessment. More in deep, ISO 11228-2 is the reference standard to the risk assessment of pushing and pulling tasks. According to this standard, the risk assessment can be carried out using two analysis levels, each one characterized by a specific method. The first level analysis is deeply used in the industrial reality, it allows a fast screening of risk factors and it is based on an evaluation checklist and tables coming from Snook&Ciriello psychophysical tables. Psychophysical tables reports experimental force values based on risk factors of load, environment and operator characteristics. Effectively, the risk level is assessed by a comparison between measured initial and maintenance forces and the corresponding force values reported in Snook & Ciriello tables. Snook&Ciriello tables are a collection of experimental data (psychophysical data) and this is the main limitation in their use because of they don’t cover all conditions that could be present in the complex industrial reality as the automotive contest is. Therefore, Fiat Group Automobiles (FGA) has internally developed a conservative method to analyze pushing and pulling tasks, according to ergonomics principles mentioned in the legislation requirements and shared with Occupational Doctors. This method allows to assess the risk of biomechanical overload of pushing and pulling tasks, when the critical operative conditions of the task are not explicitly comparable to the discrete value of psychophysical tables. The developed method is based on standardize procedure to experimentally measure initial and maintenance forces as well as to statistically elaborate the experimental data. The application of this procedure allows to have repeatable and comparable experimental data, where an interpretability of the current legislation in open, because of ISO standard does not give detailed and unambiguous information to acquire and statistically manage the experimental forces data. Finally, a case study of FGA methodology application will be illustrated.
A Product Design Process to Evaluate Users’ Intrinsic Satisfaction—Designing Center Consoles in Cars
Authors: Muraji Shu , Yamamoto Masayuki Kurihara Takashi Suzuki Miwa Nakanishi Tsuneyuki
Published: May 2022

Popular products such as cars, consumer electronics, and electronics have attained a high level of efficiency, usability, and performance. To increase user satisfaction by improving these aspects becomes very difficult. Since the standards of the users are becoming diverse, products that are superior in these aspects are not necessarily accepted, which is seen in the recent trend where users accept some mobile phones. Therefore, the introduction of a more comprehensive evaluation in the design process is necessary to satisfy the users’ intrinsic satisfaction. This study aims to suggest a process to determine a products’ design using intrinsic user satisfaction as indexes. Specifically targeting the center console in cars, this study models the relationship of the users’ intrinsic satisfaction and design elements of a car. In addition, by formulating this relationship, this study establishes a quantitative method to evaluate the users’ intrinsic satisfaction.
Synesthetic Metering for Speed
Authors: Paulo Cabrala João , Míriam Lemos Oliveira Mendonçaab Rosângela
Published: May 2022

As proven by some studies, the approach to estimate the speed of travel has significant levels of error. In addition, the meters usually used, such as the speedometer, are not sufficient for the drivers perception of risks. Often the driver’s perception of speed is based on a comparison with other drivers present on the road. In addition, cars tend to be acoustically isolated and the noise of the engine therefore tends to be minimized. In this way, the references are even fewer and so drivers lack for signals that trigger their self-awareness with regard to the level of danger of driving at high speed. This is true, specially, concerning the situation when the driver needs to arrive at a certain time at his destination. Devices such as GPS and on-board computers provide guidance on travel time and arrival and the maximum speed allowed on any road, but they still do not provide the information necessary for a more effective use of speed and more efficient travel in terms of saving time. For this reason, we propose a system that advises the driver on the best speed in every part of the route, giving a better performance without exceeding the speed limit. This system uses auditory icons that reproduce the sound of a natural event (e.g. the wind) present in some situations while driving. Since this adds on channels of reception with a natural signal this is an effective and non-intrusive way of informing the driver.
Work Ergonomic Analysis and Change Laboratory: Similarities and Complementarities Between Interventionist Methods
Authors: AG Vilela Rodolfo , Antônio Marco , Wey Berti Mendes e Renata , Gomes Reis Lopes Manoela , M. Almeida f Ildeberto , Marçal Jackson Filhog José
Published: May 2022

The objective of this study is to compare the interventionist methodologies of Ergonomic Work Analysis (EWA) influenced by a French approach, and the Change Laboratory method based on the Activity Theory approach. This study aims at identifying complementarities and convergences between these methods to improve work related accident and diseases prevention. Reference publications of these two methodologies were selected to make a theoretical comparison between the approaches. The criteria selected for the comparison were: units of analysis and key concepts, main methodological principles, the role of demand, main steps of the method, the relationship between the diagnosis and creation and construction of new solutions processes, the role of researcher / interventionist, the role of practitioners and ethical issues. Based on this comparison, resources will be drawn from both approaches to map out the ingredients for efficient intervention for the prevention of accidents and health problems related to work. We argue that ergonomic analysis has as its main strength deep and detailed understanding of the actions and operations of workers engaged in real work, while, on the other hand, the Change Laboratory seeks understanding within a historical and systemic perspective and emphasizes intervention in the whole activity system.
Accessibility Passport Model for Designing Inclusive Games– A Requirement Engineering Viewpoint
Authors: Mohammad Mustaquim Moyen
Published: May 2022

While disability and other types of user exclusion issues are evident in society at present and thereby universal design is a key concern in design society, less effort towards inclusive games design is obvious. Designing inclusive games are authoritative and it would therefore be important to recognize any framework or model that could be followed to come up with any well-adjusted inclusive games design solution. In this paper an accessibility passport model for inclusive games design was proposed. The model was based on and originated from a requirement engineering model for inclusive games design which was also presented. The accessibility passport model was combined with the requirement engineering model together with different accessibility passport features which could be suitable for inclusive games design as projected in this the paper. The accessibility passport features and model were then discussed within the context of sustainable system design and a new concept of universal design, where usability augmentation was prioritized through the practice of universal design by considering further than the scope of accessibility issues only intended for triggering the innovation process for future games design.
An Ergonomic Vision of Actors and Resources in Distance Education Environment
Authors: Thomas Martins Edgard Thomas Martinsb Isnard , Márcio Soaresc Marcelo
Published: May 2022

Comparative studies aim to identify, describe and evaluate conceptual and technological innovations focused on the continuous training of students with emphasis on distance education methodologies and tools. The learning process in web-based instructional models becomes a complex commitment to educator, just as the blackboard and the chalk paradigm had been in the past, when the blackboard and chalk were deemed the formal means of transfer of knowledge between the professor and the student in the traditional school environment. Breaking this paradigm is just the initial step to accept the "Invisible School" and the "remote" teacher, who can be "turned on and off" by the students, according to their time constraints and learning conveniences, which are as flexible as the selection of roadmaps on the development of the curriculum frameworks of what should be learned, and where to learn, with whom to learn and when to learn. Some Distance Education environments are being designed by web-designers and html language programmers, and it is expected that the final product, besides presenting a friendly interface and pleasant visual, can also present a pedagogical environment and ergonomic relationships with its users.
Influence of Web Usability as Stimulus to Generate Positive Emotions
Authors: Cecilia Landa Ávilaa Irma , Roselia Prado Leónb Lilia
Published: May 2022

The study of web usability has forayed into increasingly subjective scopes, such as user experience, where usability is regarded as a stimulus that may impact in the generation of positive emotions. This nexus between usability and positive emomciones still has several questions, since the studies show mixed results and have not been able to establish a critical relationship between them. However, there is a tendency to suggest that better usability is the trigger for express positive emotions about the use of that product. An usability test allow us get metrics about the usability components, which were analyzed in relation to the positive emotions reported by users through the PrEMO tool after using a design. Do the results we can assume that the relationship of the usability with positive emotions lacks a determinant structure, even if the frequency in which emotions like fascination were generated made us assume that it would be strongly affected by variations in the usability, otherwise the further analysis showed negative relationship and pointed that usability metrics like quality level of completed tasks and perceived mental effort are those that have a greater relationship with the expression of positive emotions.