bluuebunny/crossref_metadata_2025 huggingface dataset:
Η διερεύνηση των μεταναστευτικών ροών στην Ελλάδα, Ισπανία, Πορτογαλία και Ιταλία κατά την οικονομική κρίση
Authors: Καλογεράκη Στεφανία
Published: October 2017

Η πρόσφατη παγκόσμια χρηματοπιστωτική και οικονομική κρίση έχει πολλαπλές επιπτώσεις που –μεταξύ άλλων– περιλαμβάνουν μεταβολές στις διεθνείς μεταναστευτικές ροές. Η παρούσα μελέτη βάσει δευτερογενούς ανάλυσης δεδομένων διερευνά τις μεταναστευτικές εισροές και εκροές σε κράτη-μέλη της Ευρωπαϊκής Ένωσης που έχουν πληγεί ιδιαίτερα συμπεριλαμβάνοντας την Ελλάδα, την Ισπανία την Πορτογαλία και την Ιταλία. Τα ευρήματα επιβεβαιώνουν την εμπειρία προηγούμενων υφέσεων αποτυπώνοντας συναφείς τάσεις. Ωστόσο, εντοπίζονται και σημαντικές διαφοροποιήσεις που υποδεικνύουν ότι οι διεθνείς μετακινήσεις συνδιαμορφώνονται υπό την επίδραση παραγόντων που δεν σχετίζονται με την οικονομική κρίση per se αλλά αντανακλούν τις ιδιαιτερότητες και μεταναστευτικά χαρακτηριστικά της εκάστοτε χώρας καθώς και ευρύτερα γεγονότα που λειτουργούν ανεξάρτητα από τις οικονομικές συνθήκες.
Για το βιβλίο: Σούλης, Σωτήρης (2015). Εφαρμοσμένη κοινωνική πολιτική. Σχεδιασμός υπηρεσιών υγείας και κοινωνικής προστασίας.
Authors: Γαλατά Παρασκευή-Βίβιαν
Published: October 2017

Δε διατίθεται περίληψη / no abstract available
Πολιτισμική ανάλυση και κοινωνιολογία του πολιτισμού στην Ελλάδα, 1980-2014: Eπισκόπηση βιβλιογραφίας και σχεδίασμα κοινωνιολογικής ερμηνείας
Authors: Δεμερτζής Νίκος , Σουλιώτης Νίκος , Μαρκατάς Γιώργος
Published: October 2017

Το κείμενο παρουσιάζει μια προκαταρκτική επισκόπηση της πολιτισμικής ανάλυσης και της πολιτισμικής κοινωνιολογίας στην Ελλάδα κατά τις τελευταίες τρεις δεκαετίες. Η επισκόπηση βασίζεται σε μια βάση δεδομένων, η οποία περιλαμβάνει δημοσιεύματα σε αυτά τα πεδία και ορισμένα βασικά βιογραφικά στοιχεία των συγγραφέων τους. Υποστηρίζουμε ότι η «πολιτισμική στροφή» τροφοδότησε στη χώρα μας μια αρκετά πλούσια αν και ταυτόχρονα κατακερματισμένη συζήτηση στην οποία δύσκολα μπορεί κανείς να διακρίνει «σχολές σκέψης». Οι Έλληνες μελετητές επικεντρώθηκαν στη μελέτη των αναπαραστάσεων σημαντικών φαινομένων (μεταξύ άλλων της εθνικής ταυτότητας, της μετανάστευσης και του αστικού χώρου) στα ΜΜΕ και τη μαζική/λαϊκή κουλτούρα. Αντίθετα, ενδιαφέρθηκαν πολύ λιγότερο για παραδοσιακά θέματα της πολιτισμικής κοινωνιολογίας και της κοινωνιολογίας του πολιτισμού όπως η πολιτιστική παραγωγή και κατανάλωση και η πολιτιστική πολιτική. Ως αποτέλεσμα των περιορισμένων χρηματοδοτικών ευκαιριών, η έρευνα υπήρξε κυρίως ατομική, μικρής κλίμακας και βασίστηκε σε ποιοτικές μεθόδους.
Ο εντυπωσιασμός στα μέσα μαζικής ενημέρωσης
Authors: Βρύζας Κώστας
Published: October 2017

[Δεν διατίθεται περίληψη / no abstract available]
Submarine vortices derived from natural gas hydrate conversion: a mechanism for ocean mixing
Authors: BARNARD A. , MAX M. D. , GUALDESI L.
Published: October 2017

We propose that the source water for some abyssal undular vortices cored by cool, low-salinity water identified at depths in excess of 2,500 m in the deepwater region of the Eastern Mediterranean Basin may be related to conversion of natural gas hydrate (NGH) in abyssal marine sediments.  The conditions for extensive formation of NGH in the gas hydrate stability zones (GHSZ) of the upper seafloor sediments existed in this region during previous glacial episodes when colder water supported a thicker GHSZ.  Seafloor warming during the most recent interglacial caused thinning of the GHSZ at its base and has driven endothermic NGH dissociation that would have released large volumes of low-salinity water and gas that would tend to pond below the base GHSZ.  Periodically, trapped low-salinity water and gas would be released into the sea through the overlying sediments.  Buoyant low-salinity water masses, supersaturated with gas and locally containing free gas would ascend and introduce a dynamic element into an otherwise generally static environment.  As a result of the interaction of the rise of this buoyant plume and Coriolis acceleration the ascending mass would begin to rotate and form a vortex tube in midwater.  NGH conversion within the seafloor introduces large coherent masses of low-salinity, lower-temperature water containing a buoyant free gas fraction from near-surface reservoirs into the abyssal depths even where there may only be a weak natural gas petroleum system.
Reconstruction of Marine Fisheries Catches for the Republic of Malta (1950-2010)
Authors: KHALFALLAH M. , DIMECH M. , ULMAN A. , ZELLER D. , PAULY D.
Published: October 2017

The marine fisheries catches of Malta were reconstructed for the period 1950-2014, including for reported and previously unreported commercial large- and small-scale catches, unmonitored fisheries catches, i.e., subsistence and recreational fisheries, as well as major discards. The present study updates and improves a previous catch reconstruction for Malta for the 1950-2010 time period. Reconstructed marine fisheries catches for Malta are nearly 1.3 times the official landings reported by the FAO and national authorities on behalf of Malta, increasing from around 1,200 t·year-1 in the 1950s to 3,700 t·year-1 in the 2010s. The discrepancy between reported and reconstructed total catches is mostly due to the subsistence catches estimated, which here consist exclusively of on-board consumption and take-home catch of commercial fishers. While the Maltese fisheries statistical system includes procedures to estimate ‘unmonitored’ commercial landings, this contribution documents that it would be beneficial to also account for non-commercial catches.
Where not to fish – reviewing and mapping fisheries restricted areas in the Aegean Sea
Authors: PETZA D. , MAINA I. , KOUKOUROUVLI N. , DIMARCHOPOULOU D. , AKRIVOS D. , KAVADAS S. , TSIKLIRAS A.C. , KARACHLE P. K. , KATSANEVAKIS S.
Published: October 2017

An up-to-date systematic review and unofficial codification of the national fisheries legislation was performed, along with an up-to-date systematic review of environmental, archaeological and maritime legislation, about spatio-temporal restrictions of fishing activities by all fishing gears in the Aegean Sea. Spatio-temporal restrictions established by the European Union and the General Fisheries Commission for the Mediterranean were also reviewed. A database was built, including detailed information on the Fisheries Restricted Areas (FRAs) being identified. All FRAs were mapped, as polygons in Geographic Information System shapefiles. The national fisheries, environmental, archeological and maritime legal framework comprises of 32, 2, 37 and 43 legal acts respectively; EU and GFCM legislation consists of one Regulation and one Recommendation respectively. A total of 511 national (254 of fisheries, 21 of environmental, 85 of archaeological and 151 of the maritime legislation), 6 EU and 4 international FRAs were identified, out of which 85.2% are located in the Aegean Sea and 14.8% in Crete. Towed or mobile gears are restricted in 88.5% of the FRAs, while static gears are restricted in only 10.2% of FRAs. Fish stocks and Posidonia oceanica beds protection are the most common reasons for regulating fishing activities (25.3% and 25.0% respectively). Most of the FRAs (85.4%) impose permanent closures. National fisheries, environmental, archaeological, maritime, EU and international FRAs cover 25.8%, 1.0%, 1.1%, 0.4%, 13.5% and 22.6% of the study area, respectively. The present study provides valuable information for the Maritime Spatial Planning in the Aegean Sea.
Chlorurus rhakoura Randall & Anderson, 1997 (Perciformes, Scaridae), an Indo-Pacific fish new for the Mediterranean Sea
Authors: INSACCO G. , ZAVA B. M.
Published: October 2017

The scarid fish Chlorurus rhakoura Randall & Anderson, 1997, of eastern Indo-Pacific origin, is recorded for the first time from the Mediterranean Sea. A small school of six individuals of this species were caught off Portopalo, Sicily, Italy in February 2017. Morphometric measurements and meristic traits are provided based on four specimens, and the possible vector of introduction of the species into the Mediterranean is briefly discussed.
The design of the “archive wall” at Aphrodisias
Authors: Kokkinia Christina
Published: October 2017

The epigraphic display carved on the north wall of the stage building of Aphrodisias’ theatre in the 3rd century CE, commonly referred to as the “archive wall”, is usually assumed to have been designed based on the chronology of the documents it includes. This paper argues instead in favor of a centripetal design, which placed in the center of the composition the most important documents in terms of their honorific value for Aphrodisias and its citizens. It is argued, here, that form and content, as expressed in the documents’ rhetoric, and the concrete privileges which the documents attested to, were more important than chronology to the designers of this dossier.Further, it is argued that there were two epigraphic phases, with the original phase most likely dating from 224 CE and including all documents carved above the orthostate course, and a later phase dating from 243 CE or slightly later, in which the inscriptions were extended to the orthostate course. Finally, it is suggested that the earliest letter of the dossier (document 4), may have been a letter by Cornelius Sulla.
The γc family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response
Authors: Spolski Rosanne , Gromer Daniel , Leonard Warren J.
Published: October 2017

Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on the sharing of a receptor component, the common cytokine receptor γ chain, γc, which is encoded by the gene mutated in humans with X-linked severe combined immunodeficiency (XSCID). Together, these cytokines play critical roles in lymphoid development, differentiation, growth, and survival as well as mediating effector function. Here, we provide an overview of the main actions of members of this cytokine family but then primarily focus on IL-2 and IL-21, discussing their dynamic interplay and contributions to a fine-tuned immune response. Moreover, we discuss the therapeutic utility of modulating their actions, particularly for autoimmunity and cancer.
A genomic atlas of human adrenal and gonad development
Authors: del Valle Ignacio , Buonocore Federica , Duncan Andrew J. , Lin Lin , Barenco Martino , Parnaik Rahul , Shah Sonia , Hubank Mike , Gerrelli Dianne , Achermann John C.
Published: October 2017

Background: In humans, the adrenal glands and gonads undergo distinct biological events between 6-10 weeks post conception (wpc), such as testis determination, the onset of steroidogenesis and primordial germ cell development. However, relatively little is currently known about the genetic mechanisms underlying these processes. We therefore aimed to generate a detailed genomic atlas of adrenal and gonad development across these critical stages of human embryonic and fetal development.

Methods: RNA was extracted from 53 tissue samples between 6-10 wpc (adrenal, testis, ovary and control). Affymetrix array analysis was performed and differential gene expression was analysed using Bioconductor. A mathematical model was constructed to investigate time-series changes across the dataset. Pathway analysis was performed using ClueGo and cellular localisation of novel factors confirmed using immunohistochemistry.

Results: Using this approach, we have identified novel components of adrenal development (e.g.ASB4,NPR3) and confirmed the role ofSRYas the main human testis-determining gene. By mathematical modelling time-series data we have found new genes up-regulated withSOX9in the testis (e.g.CITED1), which may represent components of the testis development pathway. We have shown that testicular steroidogenesis has a distinct onset at around 8 wpc and identified potential novel components in adrenal and testicular steroidogenesis (e.g.MGARP,FOXO4,MAP3K15,GRAMD1B,RMND2), as well as testis biomarkers (e.g.SCUBE1). We have also shown that the developing human ovary expresses distinct subsets of genes (e.g.OR10G9,OR4D5), but enrichment for established biological pathways is limited.

Conclusion: This genomic atlas is revealing important novel aspects of human development and new candidate genes for adrenal and reproductive disorders.
Analysis of Applicability of Approaches to Factor Analysis During the Monitoring Investment Projects Cost Deviations in Oil and Gas Industry
Authors: Демкин Игорь , Demkin Igor , Власов Д. , Vlasov D. , Бархатов Владимир , Barkhatov Vladimir
Published: October 2017

Strategic projects of oil and gas companies regularly overcome the budget. High capitalization of these projects leads to the fact that even small relative cost deviations result in significant additional investments. Under present conditions of economic and political pressure, characterized by a limited opportunity to raise loan capital, there can be no additional investments leading to impossibility of new oil and gas projects realization or stop those being realized. One of the ways to prevent such a negative scenario is to improve the project planning system taking into account the results of monitoring the project portfolio cost deviations. It will not only allow companies to take into account the causes of deviations in several projects, but also help to develop and implement proactive measures.
Project Manager’s Competencies in Renewable Energy Projects
Authors: Логинова Екатерина , Loginova Ekaterina
Published: October 2017

This research examines renewable energy (RE) project manager competencies required by USA labor market using the analyses of project manager Internet job advertisements. It was realized by collecting and coding the requirements from the job advertisements in April 2017. 1500 vacancies were found by the website, but only 150 of them were relevant for this work (they were filtered according to some formal criteria). From the data obtained from advertisement analyses, the pool of job candidate’s competencies required by the market was compiled. The most common requirements were compared with IPMA and SOVNET competency standards for project managers. The research shows that companies are seeking a candidate with bachelor degree in engineering, project management and specific sectorial certificates, 6 years of professional experience related to project management. Some competencies coincide with the standards and the other are referred to specific RE skills.
Peculiarities of managing a development program in the pharmaceutical company: formation and monitoring
Authors: Фролкина Екатерина , Frolkina Ekaterina
Published: October 2017

The paper is devoted to a new approach to project planning and programme planning in the pharmaceutical industry that allows to simplify and standardize the process of project selection and program formation by introducing clear evaluation criteria, establishing several consecutive selection stages, optimizing and balancing the composition of projects. The proposed approach is build considering the peculiarities of the pharmaceutical industry, business processes in companies and existing projects. New two-level system for monitoring and control was developed to integrate tactical and strategic level of programme management which allows to link the achievement of project goals with the achievement of benefits and programme goals at various milestones of implementation.
Measuring Literary Reading Motivation: Questionnaires Design and Pilot Testing
Authors: Chrysos Michail
Published: October 2017

This study aims to present the design and pilot testing procedures of the two specific self-report questionnaires were used to measure the two key aspects of reading motivation, self-efficacy and intrinsic motivation in the field of literary (narrative) reading, and the partial factors that jointly shape them. These instruments were outlined in advance, tested on a small scale and finally administered in a pre-post (quasi)experimental-control group research study, in order to investigate the effect of an intervention reading program to 6 graders. The measurement tools have good validity and reliability evidence, but further construct validity analysis should be done.
Investigation of the Effects of Mathematical Thinking States of Form Teachers on Their Mathematics Teaching Anxieties
Authors: Yorulmaz Alper , Altintas Sedat , Sidekli Sabri
Published: October 2017

The state of mathematical thinking is considered to have an effect on the formation of anxiety regarding teaching mathematics. It is hypothesized that with the formation of mathematical thinking, the anxiety in teachers regarding teaching mathematics will be reduced. Since mathematical thinking is a skill acquired starting from the early years of education, the anxiety in form teachers in primary school regarding teaching mathematics is important. Within this context, the objective of this study is to investigate the effect of mathematical thinking states of form teachers on their anxieties regarding mathematics teaching. The sample group comprises 194 form teachers working in state schools of Bagcilar district, Istanbul province in the spring term of 2015-2016 academic year. As data collection tools, mathematical thinking scale and anxiety scale for the mathematics teaching anxiety of form teachers were used. To test the predictive power of mathematical thinking regarding the mathematics teaching anxiety, Multiple Linear Regression Analysis was used. It was found that the form teachers had high mathematical thinking scores and had low anxiety scores. A low degree, negative and significant correlation was found between the mathematical thinking and anxiety of form teachers regarding mathematics teaching. Moreover, it was found that mathematical thinking had an effect on the anxiety in form teachers regarding mathematics teaching.
Evaluation of Prospective Teachers in Terms of Academic Self-Efficacy and Professional Competence
Authors: Aslan Mahire , Bakir Asli Agiroglu
Published: October 2017

This study aims to determine the relationship between the self-efficacy perceptions of the prospective teachers and the levels of their professional competence. In the study, relational screening model is used and it is investigated whether prospective teachers' perceptions of academic self-efficacy and professional competence differed according to various variables. The population of the research constitutes 1430 university students (prospective teachers) who are educated in Inonu University Pedagogical Formation Education (PFE) Program in 2015-2016 academic year. In the sample of the study, there are 537 participants who were determined by random sampling method. The Ohio Teacher Competence Scale and The Academic Self-Efficacy Scale (Turkish versions) are used as a data collection tool. In the analysis of the data, the standard deviation, frequency, percentage and arithmetic mean of respondents were calculated. One-way analysis of variance, ANOVA and Scheffe Test are used. The main result of this research is that the perceptions of academic self-efficacy of prospective teachers are "Moderate" but their perceptions of professional competence are in level "Very". According to this result, prospective teachers are of the opinion that the teaching profession can be achieved with “a moderate level of academic competence”.
The appeal of the ‘Old School’: From De cierta manera/One Way or Another (1974) to Conducta/Behaviour (2014)
Authors: Fehimović Dunja
Published: October 2017

This article compares the critical perspectives on society, education and morality found in Sara Gómez’s classic De cierta manera/One Way or Another (1974) and Ernesto Daranas’ more recent Conducta/Behaviour (2014). Considering the films’ engagement with cinematic traditions from Italian neo-realism to melodrama, it argues that Conducta displays a return to a cinematic ‘old school’ in terms of its emotional appeal, its focus on a transcendent individual and its tendency to turn the social and physical context into aesthetically appealing backdrop. Given the overdetermination of both children and teachers in Cuba’s history, the analysis shows the conversion of Daranas’ teacher, Carmela, into a sanctified, syncretic heroine and her pupil, Chala, into a choteo-imbued, macho, miniature Hombre Nuevo (new man). Thus, the critical, imperfect and collective qualities of Gómez’s rapidly transforming revolutionary society are displaced in Daranas’ film by a melancholy aesthetic, a quasi-sacred aura and a coercive kind of care. The problem, therefore, does not necessarily lie in this film’s use of ‘old-school’ narrative techniques, but rather in their deployment to cement values of ‘authentic’ revolutionary spirit and ‘true’ cubanía – in other words, to reinforce the appeal of the ‘old school’.
Juan of the Dead: Anxious consumption and zombie cinema in Cuba
Authors: Ballina Bianka
Published: October 2017

Cuban cinema has undergone a resurgence over the past decade, often relying on different foreign sources of funding, particularly transnational co-production agreements. As global audience appeal becomes a critical factor in national cinema, incorporating global media resources entails forms of resistance that need not be guided by a refusal to engage with hegemonic forces. Instead, audio-visual production strives to acknowledge and mobilize the elasticity of social, ideological and geopolitical borders by experimenting with national and global criteria. This article explores this media environment through Alejandro Brugués’s film Juan de los muertos/Juan of the Dead (2011). The film mediates the complex material and ideological transformations in Cuba over the past two decades and provides a fertile ground for exploring the circulation of anxieties around global consumption. This article examines how Juan of the Dead contributes towards the continued reformulation of both Cuban and genre cinemas while also reproducing pervasive discourses around race, gender and sexuality in Cuba.
Obsolescence, media and the global imaginary: Thing motifs in Cuban cinema
Authors: Balaisis Nicholas
Published: October 2017

This article looks at the focus on things in recent Cuban film and media. New tourist trinkets, improvised domestic tools and obsolescent media have emerged as areas of interest for Cuban and Cuban-trained filmmakers, an interest that reflects Cuba’s changing place within the global imaginary. Cuban things are unique – and compelling – in the way that they index the context of late socialism, particularly Cuba’s long economic isolation from American trade and goods. The distinctness of these objects has fuelled recent global interest in Cuban design as they represent alternatives to an increasingly homogenous cycle of global commodities and the perceived dematerialization of culture as a result of digital media and technology. Things in recent Cuban film reflect Cuba’s newfound status as ‘obsolescent chic’, at the same time as they recast this global fascination in ways that preserve national histories and local specificity.
Julio’s cultural mission: A homage to Julio García Espinosa, 1926–2016
Authors: Venegas Cristina
Published: October 2017

In memory of celebrated Cuban filmmaker, theorist and cultural worker/leader Julio García Espinosa, this article outlines his early cultural productions as a necessary precursor of his celebrated manifesto ‘For an Imperfect Cinema’.
Caracterización arqueométrica de la cerámica del Castillo de Albarracín (Teruel, España) en la transición entre los siglos XII y XIII
Authors: Pérez-Arantegui J. , Hernández Pardos A.
Published: October 2017

El presente estudio se centra en el repertorio cerámico procedente del Castillo de Albarracín entre finales del siglo XII e inicios del XIII, uno de períodos peor reconocidos en el Aragón meridional, pero mejor representados en este yacimiento arqueológico. Se ha obtenido la composición química de varios grupos cerámicos, mediante espectroscopia óptica de emisión con plasma de acoplamiento inductivo-ICP (Inductively Coupled Plasma). La incorporación de análisis arqueométricos al estudio morfológico permite proponer varios probables centros productores en este período, destacando especialmente los recipientes procedentes del Levante almohade.
Prospeção geofísica de vestígios de estruturas do antigo Paço Real de São Francisco (Évora), com uso de georradar e laser scanner
Authors: Oliveira R. J. , Caldeira B. , Borges J. F.
Published: October 2017

No local onde atualmente existe o Palácio de D. Manuel, em Évora, terá existido o Paço Real de S. Francisco, uma das residências da monarquia portuguesa entre o século XVI e XVII. O edifício entrou em declínio em 1616, tendo sido adaptado para outras ocupações, abandonado e destruído por incêndios. Entre este edifício e o mercado existem vestígios arqueológicos, descobertos durante a execução de obras urbanas. O atual edifício foi o resultado de várias alterações sobre o que restou, a última delas na parte frontal da sua fachada, onde foram removidas umas escadas monumentais de que há registo fotográfico. Este trabalho pretende mostrar a existência de vestígios do antigo palácio, integrados nas estruturas que atualmente existem, no âmbito da investigação de metodologias eficazes de aplicação de técnicas geofísicas em Arqueologia. Para concretizar o objetivo, procedeu-se à realização de prospeção geofísica, com georradar, nas áreas adjacentes ao palácio, e com laser scanner, de modo a integrar os resultados de georradar numa representação tridimensional do atual edifício. Os resultados evidenciam a existência de estruturas que terão correspondido à escadaria do palácio e de vestígios compatíveis com a opinião de que o palácio se prolongaria para o lado onde existe o atual mercado.
Estudio de pátinas procedentes de hornos de fundición en la Real Fábrica de Artillería de Sevilla (s. XVII)
Authors: Flores-Alés V. , Alejandre J. , Martín del Río J.J. , Blasco-López F.J. , Núñez C.
Published: October 2017

El objeto principal del presente trabajo es determinar la estructura de los estratos que componen el revestimiento del paramento de las zonas identificadas en la Fábrica de Artillería de Sevilla como “fundición vieja” y “fundición nueva” y realizar la caracterización química de los mismos con la finalidad concreta de identificar los posibles depósitos metálicos que pudieran haberse acumulado durante la actividad fabril de fundición llevada a cabo en el edificio desde finales del siglo XVI hasta el XX (Sobrino 2011). Hay que señalar que las posibles pátinas han sido sucesivamente ocultadas mediante el pintado de los paramentos, de ahí que la serie estratigráfica acumulada a lo largo del tiempo corresponda a una secuencia alterna (Barbero, 2013). Las muestras fueron evaluadas inicialmente mediante microscopía óptica para la determinación de los estratos existentes. Mediante microfluorescencia de rayos X y microscopía electrónica se identificaron las partículas que contenían metales y se determinó su composición química (Berthold, 2009). Este análisis confirmó la hipótesis de la presencia de elementos metálicos pesados, destacando especialmente la presencia de hierro, habiéndose detectado también en las distintas muestras en proporciones minoritarias, aunque relevantes (cobre, cinc y, en casos aislados, plomo y níquel). Todos ellos responden a su posible presencia en los materiales utilizados en la fundición.
Using N-terminal pro-B-type natriuretic peptide to diagnose cardiac abnormalities in children with dyspneaen with dyspnea
Authors: Mukalla Zakaria , Nova Ria , Legiran Legiran , Yangtjik Yangtjik
Published: October 2017

Background. Dyspnea could be caused by various reason, one of which is the presence of cardiac abnormality. Physical examination sometimes difficult to distinguish breath caused by heart abnormalities, especially small children, so we need another way to find out.Objective. To evaluate whether the examination of NT-proBNP levels can be used as a screening tool to diagnose cardiac abnormality in children presenting with dyspnea.Methods. A Cross sectional study was conducted from August to October 2015 on pediatric patients aged 1 month to 18 years presenting with dyspnea in pediatric ward Mohammad Hoesin Hospital Palembang. All subjects performed blood sampling for NT-proBNP examination and echocardiography to assess the presence of cardiac abnormalities. The diagnostic value analyzed by ROC curve, and determined the optimal cut-off point, sensitivity and specificity. Result. We obtained 58 subjects with median age 9.5 (1-180) months, consisted of 39 subjects with cardiac abnormalities and 19 subjects without cardiac abnormality. There is a significant difference (p = 0.002) of NT-proBNP levels in both groups with a median  1,775 (189-9,000) pg/ml vs 759 (245-9,000) pg/ml. In ROC curve analysis, AUC value was 0.75, and at the optimal cut-off point 1,235 pg/ml, sensitivity was 74.4% and specificity was 73.7%.Conclusion. The level of NT-proBNP can be used to diagnose cardiac abnormalities in children presenting with dyspnea.
Serum ferritin, serum nitric oxide, and cognitive function in pediatric thalassemia major
Authors: Qurbani Septiana Nur , Reniarti Lelani , Chairulfatah Alex
Published: October 2017

Background Hemolysis and repeated blood transfusions in children with thalassemia major cause iron overload in various organs, including the brain, and may lead to neurodegeneration. Hemolysis also causes decreased levels of nitric oxide, which serves as a volume transmitter and slow dynamic modulation, leading to cognitive impairment.Objective To assess for correlations between serum ferritin as well as nitric oxide levels and cognitive function in children with thalassemia major.  Methods This analytical study with cross-sectional design on 40 hemosiderotic thalassemia major patients aged 6−14 years, was done at the Thalassemia Clinic in Dr. Hasan Sadikin Hospital, Bandung, West Java, from May to June 2015. Serum ferritin measurements were performed by an electrochemiluminescence immunoassay; serum nitric oxide was assayed by a colorimetric procedure based on Griess reaction; and cognitive function was assessed by the Wechsler Intelligence Scale for Children test. Statistical analysis was done using Spearman’s Rank correlation, with a significance value of 0.05.Results Abnormal values in verbal, performance, and full scale IQ were found in 35%, 57.5% and 57.5%, respectively. Serum nitric oxide level was significantly correlated with performance IQ (P=0.022), but not with verbal IQ (P=0.359) or full scale IQ (P=0.164). There were also no significant correlations between serum ferritin level and full scale, verbal, or performance IQ (P=0.377, 0.460, and 0.822, respectively).Conclusion Lower serum nitric oxide level is significantly correlated to lower cognitive function, specifically in the performance IQ category. However, serum ferritin level has no clear correlation with cognitive function.
The pediatric index of mortality 3 score to predict mortality in a pediatric intensive care unit in Palembang, South Sumatera, Indonesia
Authors: Sari Destiana Sera Puspita , Saputra Indra , Triratna Silvia , Saleh Mgs. Irsan
Published: October 2017

Background For critically ill patients in the pediatric intensive care unit (PICU), a scoring system is helpful for assessing the severity of morbidity and predicting the risk of mortality. The Pediatric Index of Mortality (PIM) 3 score consists of ten easy simple variables, so that the probability of death can be assessed prior to undergoing advanced therapies. The PIM 3 score in inexpensive and comprised of routine laboratory variables performed in PICU patients. In Indonesia, studies to validate the PIM 3 score have been limited.Objective To evaluate the PIM 3 score for predicting the probability of death in the PICU, Dr. Mohammad Hoesin Hospital (MHH), Palembang.Methods A prospective, cohort study was performed in the PICU, MHH, Palembang, from February to April 2016. The PIM 3 score was calculated within 2 hours of patients admission to the PICU by an  android calculator application. PIM3 score and mortality were analyzed by Mann-Whitney test; calibration was performed by Hosmer-Lameshow goodness of fit test, discrimination was done by receiver operating characteristic (ROC) curve analysis; and standardized mortality ratio (SMR) was calculated.Results During the study period there were 81 PICU patients, 69 children were included, ranging in age from 1,5 to 187 months. The overall mortality rate was 40,58%. The most common illnesses in our subjects were malignancy (17,4%), post non-thoracic surgery (14,5%), dengue shock syndrome (14,5%), respiratory disease (13%), and neurological disease (11,6%). Subjects’ PIM3 scores ranged from 1,02% to 58,84%, with means of 26,08% in non-survivors and 13,05% in survivors. The SMR was 2,24, indicating that death was underpredicted. The AUC of 0,771 (95% CI of 0,651 to 0,891) indicated that the PIM3 score had good discrimination.Conclusion In Mohammad Hoesin Hospital, Palembang, South Sumatera, the PIM 3 can be used to predict mortality in PICU patients, but the score should be multiplied by a factor of 2.24. This recalibration is needed due to the presumed lower standard of care at this hospital compared to that of the originating PIM 3 institutions in developed countries.
Prevalence of hepatitis and its correlation with serum ferritin and aminotransferase levels among thalassemia major patients in Indonesia
Authors: Wahidiyat Pustika Amalia , Liauw Felix , Adnani Nitish Basant , Putriasih Siti Ayu
Published: October 2017

Background Thalassemia major patients who undergo routine transfusion have an increased risk of acquiring transfusion-transmitted infections (TTI), including hepatitis B and C. These diseases have serious implications and may affect the serum ferritin and aminotransferase levels of thalassemia major patients.Objectives To identify the prevalence of hepatitis B and/or C infections among thalassemia major patients and to evaluate its correlation with serum ferritin and aminotransferase levels.Methods This was across-sectional study conducted at the Thalassemia Center of Dr. Cipto Mangunkusumo Hospital in Jakarta, Indonesia. The subjects were screened for hepatitis B and C infections, and their serum ferritin and aminotransferase levels were also measured.Results In total, 621 subjects were included in the study, among which 5 subjects tested positive for hepatitis B surface antigen (HBsAg) (0.8%), 111 subjects tested positive for anti-HCV (17.8%), and 5 subjects tested positive for both HBsAg and anti-HCV (0.8%). The subjects who tested positive for hepatitis B, hepatitis C, or both showed significantly higher values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and serum ferritin compared to their negative counterparts. Moreover, serum ferritin showed a positive, moderate correlation with both AST and ALT.Conclusion This study shows a significant association between hepatitis and serum ferritin as well as aminotransferase levels. Early detection and early management of hepatitis B and C infections is warranted to minimize the occurrence of liver damage in thalassemia major patients.
Diagnostic value of newborn foot length to predict gestational age
Authors: Fawziah Mutia Farah , Soebagyo Bambang , Hidayah Dwi
Published: October 2017

Background  Identification of gestational age, especially within 48 hours of birth, is crucial for newborns, as the earlier preterm status is detected, the earlier the child can receive optimal management. Newborn foot length is an anthropometric measurement which is easy to perform, inexpensive, and potentially efficient for predicting gestational age.Objective  To analyze the diagnostic value of newborn foot length in predicting gestational age.Methods  This diagnostic study was performed between October 2016 and February 2017 in the High Care Unit of Neonates at Dr. Moewardi General Hospital, Surakarta. A total of 152 newborns were consecutively selected and underwent right foot length measurements before 96 hours of age. The correlation between newborn foot length to classify as full term and gestational age was analyzed with Spearman’s correlation test because of non-normal data distribution. The cut-off point of newborn foot length was calculated by receiver operating characteristic (ROC) curve and diagnostic values of newborn foot length were analyzed by 2 x 2 table with SPSS 21.0 software.Results There were no significant differences between male and female newborns in terms of gestational age, birth weight, choronological age, and newborn foot length (P>0.05). Newborn foot length and gestational age had a significant correlation (r=0.53; P=0.000). The optimal cut-off newborn foot length to predict full term status was 7.1 cm. Newborn foot length below 7.1 cm had sensitivity 75%, specificity 98%, positive predictive value 94.3%, negative predictive value 90.6%, positive likelihood ratio 40.5, negative likelihood ratio 0.25, and post-test probability 94.29%, to predict preterm status in newborns.Conclusion  Newborn foot length can be used to predict gestational age, especially for the purpose of differentiating between preterm and full term newborns.
Intravenous paracetamol and patent ductus arteriosus closure in preterm infants
Authors: Adriansyah Rizky , Idris Nikmah S. , Djer Mulyadi M. , Putra Sukman T. , Rohsiswatmo Rinawati
Published: October 2017

Background Indomethacin and ibuprofen are the drugs of choice for closure of patent ductus arteriosus (PDA) in preterm infants. However, intravenous preparations are of limited availability in Indonesia. Circumstantial evidence has shown that intravenous paracetamol may be an alternative therapy for PDA closure in premature infants.Objective To evaluate the effect of intravenous paracetamol on PDA closure in preterm infants.Methods A before-and-after study was conducted between May and August 2014 in Cipto Mangunkusumo General Hospital, Jakarta in preterm infants with hemodynamically significant PDAs, as established by echocardiography using the following criteria: duct diameter >1.4 mm/kg, left atrium to aorta ratio >1.4, and mean velocity in the left pulmonary artery >0.42 m/s or mean diastolic velocity in the left pulmonary artery >0.2 m/s. Subjects, aged 2 and 7 days, received intravenous paracetamol (15 mg/kg every six hours) for 3 days. Paired T-test was used to compare pre-intervention PDA diameter to those assessed at 24 hours after the intervention and at 14 days of life.Results Twenty-nine subjects had a mean gestational age of 30.8 weeks and mean birth weight of 1,347 grams. Nineteen (65.5%) patients had closed PDAs at the day 14 evaluation, 1 experienced PDA reopening, and 9 had failed PDA closure. No liver toxicity was identified. Mean duct diameters before, 24 hours after the intervention, and at 14 days of life were 3.0, 0.9, and 0.6 mm, respectively (P<0.0001).Conclusion Intravenous paracetamol seems to be reasonably effective for PDA closure in preterm infants.
Reflections on Legal Language
Authors: Barros Filho Geraldo Carreiro de , Carreiro Larissa Sampaio Gonçalves , Farias Athena De Albuquerque
Published: October 2017

The article proposes the discursion of what legal language is worth - its orality and its writing, support pillars of this field, which the Law Enforcement agents use in their profession to be well understood and thus win the case with the thesis presented in proceedings. What would be the characteristic of this profession? The need for conviction - a major tool of all those who take on the firm purpose of achieving justice, by right. There are understandings and theses in young scholars and others not so much, of those who are present in Warat, Koch, Bakhtin, and Tercero, who are fundamental to this study, who draw up understandings regarding the conduct and use of legal language, its current peculiarities and its traditions with a force of immutability, but that makes the legal work - teaching or militant, the differential of the operators that know and dominate and those who only observe.
A Twentieth-Century Merchant Network Centered on Jeddah: The Correspondence of Muḥammad b. Aḥmad Bin Ḥimd
Authors: Freitag Ulrike
Published: October 2017

This article examines a collection of merchant letters which arrived between 1919 and 1946 in the Red Sea port of Jeddah. Their recipient, Muḥammad b. Aḥmad Bin Ḥimd, was a merchant of Hadhrami origin, deeply embedded in the trade with grain, foodstuffs and other goods in the Red Sea area. Based on a survey of some of the documents, the article describes the merchant’s network as well as the content of some sample letters to unlock their potential as an important source for the economic history of the region.
A zase ten učitel?
Authors: Urbánek Petr
Published: October 2017

Letošní první číslo Pedagogiky přináší čtyři klíčové statě. S výjimkou jediné mají všechny příspěvky značně hutný rozsah. Ten by ovšem čtenáře neměl nikterak odrazovat, neboť texty jsou zajímavé a čtivé a zabývají se významnými, aktuálními a také nově uchopenými tématy. Přitažlivost čísla zvyšuje i různorodost typů publikovaných textů; zastoupena je teoretická, přehledová i výzkumná studie
Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency
Authors: Pena Izabella A , Roussel Yann , Daniel Kate , Mongeon Kevin , Johnstone Devon , Weinschutz Mendes Hellen , Bosma Marjolein , Saxena Vishal , Lepage Nathalie , Chakraborty Pranesh , Dyment David A , van Karnebeek Clara D M , Verhoeven-Duif Nanda , Bui Tuan Vu , Boycott Kym M , Ekker Marc , MacKenzie Alex
Published: October 2017

Pyridoxine-dependent epilepsy (PDE) is a severe neonatal seizure disorder and is here modeled in aldh7a1 -/- zebrafish. Mutant larvae display spontaneous..

Pyridoxine-dependent epilepsy (PDE) is a rare disease characterized by mutations in the lysine degradation gene ALDH7A1 leading to recurrent neonatal seizures, which are uniquely alleviated by high doses of pyridoxine or pyridoxal 5′-phosphate (vitamin B6 vitamers). Despite treatment, neurodevelopmental disabilities are still observed in most PDE patients underlining the need for adjunct therapies. Over 60 years after the initial description of PDE, we report the first animal model for this disease: an aldh7a1-null zebrafish (Danio rerio) displaying deficient lysine metabolism and spontaneous and recurrent seizures in the larval stage (10 days postfertilization). Epileptiform electrographic activity was observed uniquely in mutants as a series of population bursts in tectal recordings. Remarkably, as is the case in human PDE, the seizures show an almost immediate sensitivity to pyridoxine and pyridoxal 5′-phosphate, with a resulting extension of the life span. Lysine supplementation aggravates the phenotype, inducing earlier seizure onset and death. By using mass spectrometry techniques, we further explored the metabolic effect of aldh7a1 knockout. Impaired lysine degradation with accumulation of PDE biomarkers, B6 deficiency, and low γ-aminobutyric acid levels were observed in the aldh7a1−/− larvae, which may play a significant role in the seizure phenotype and PDE pathogenesis. This novel model provides valuable insights into PDE pathophysiology; further research may offer new opportunities for drug discovery to control seizure activity and improve neurodevelopmental outcomes for PDE.
Quality Protein Maize Based on Reducing Sulfur in Leaf Cells
Authors: Planta Jose , Messing Joachim
Published: October 2017

Low levels of the essential amino acids lysine (Lys) and methionine (Met) in a maize-based diet are a major cost to feed and food. Lys deficiency is due to the abundance of Lys-poor proteins in maize kernels. Although a maize mutant, opaque-2 (o2), has sufficient levels of Lys, its soft kernel renders it unfit for storage and transportation. Breeders overcame this problem by selecting quantitative trait loci (QTL) restoring kernel hardness in the presence of o2, a variety called Quality Protein Maize (QPM). Although at least one QTL acts by enhancing the expression of the γ-zein proteins, we could surprisingly achieve rebalancing of the Lys content and a vitreous kernel phenotype by targeting suppression of γ-zeins without the o2 mutant. Reduced levels of γ-zeins were achieved with RNA interference (RNAi). Another transgenic event, PE5 expresses the Escherichia coli enzyme 3′-phosphoadenosine-5′-phosphosulfate reductase involved in sulfate assimilation, specifically in leaves. The stacked transgenic events produce a vitreous endosperm, which has higher Lys level than the classical opaque W64Ao2 variant. Moreover, due to the increased sulfate reduction in the leaf, Met level is elevated in the seed. Such a combination of transgenes produces hybrid seeds superior to classical QPMs that would neither require a costly feed mix nor synthetic Met supplementation, potentially creating a novel and cost-effective means for improving maize nutritional quality.
Community-Based Research and the Faith-Based Campus
Authors: Janzen Rich , Reimer Sam , Chapman Mark , Ochocka Joanna
Published: October 2017

Over recent decades a significant shift has been taking hold on campuses of higher education in Canada and around the world. It is a shift towards community engagement. In this article our focus is on the research aspect of community engagement, and explores how this shift towards community-based research is playing itself out on the faith-based campus. We provide examples of two Canadian faith-based universities (Crandall University and Tyndale University College & Seminary) who were involved in a two-year community-campus research partnership called “The role of churches in immigrant settlement and integration”. Reflecting on this experience we learned that, similar to other institutions of higher education, an intentional shift towards community-based research on the faith-based campus requires attention to both the internal and external drivers that support such a shift. We also learned that faith-based campuses have their own unique ethos and therefore have distinctive drivers that can be leveraged to support such a shift. While our learnings arise out of the experience of two participating universities, their applicability may be of interest to other faith-based campuses in Canada and elsewhere.
Addiction Recovery, Gardening, and Faith: The Garden of Allan
Authors: Wood Grant , Rousseaux JP
Published: October 2017

The Garden of Allan is far from the Garden of Eden, but God, the first and ultimate gardener is there. Teen Challenge (TC), a faith-based, residential drug and alcohol rehabilitation program on 10 acres of land in rural Saskatchewan near the town of Allan. What began with a simple church bulletin, with a notice saying that Teen Challenge needed donations of fruits and vegetables lead to the development of an active gardening and food project at the centre. What could have been a simple donation developed into a project that has dramatically changed the life of the volunteer coordinator, and the lives of several students in the program. In addition to developing their faith, and using their faith to overcome their addictions, the TC program emphasizes community living, life skills, health and recreation, music, art, and character development. Gardening and food related activities are valuable life skills, are part of a healthy and healing lifestyle, and further develop the student’s faith. Gardening activities can be extremely therapeutic in relieving stresses including depression and anxiety, which are common in the lives of those struggling with alcohol and drug addiction. Gardening can also be extremely rewarding, yielding food for sustenance, success, achievement, validation, and prayers answered. In the Garden of Allan, gardening is both indoor and outdoor. During inclement times of the year, the students grow nutrient dense microgreens that are proven beneficial in repairing damage caused by drugs and alcohol. The Garden of Allan is where faith and gardens grow.