bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S2 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
Authors: Anderhub Simon J. , Mak Grace Wing-Yan , Gurden Mark D. , Faisal Amir , Drosopoulos Konstantinos , Walsh Katie , Woodward Hannah L. , Innocenti Paolo , Westwood Isaac M. , Naud Sébastien , Hayes Angela , Theofani Efthymia , Filosto Simone , Saville Harry , Burke Rosemary , van Montfort Rob L.M. , Raynaud Florence I. , Blagg Julian , Hoelder Swen , Eccles Suzanne A. , Linardopoulos Spiros
Published: April 2023

Cellular activity of BOS172722 in correlation to tissue of origin, MPS1 mRNA expression and doubling time
Supplementary Table S4 from Nuclear Factor-κB Promotes Urothelial Tumorigenesis and Cancer Progression via Cooperation with Androgen Receptor Signaling
Authors: Inoue Satoshi , Ide Hiroki , Mizushima Taichi , Jiang Guiyang , Netto George J. , Gotoh Momokazu , Miyamoto Hiroshi
Published: April 2023

Univariate and multivariate Cox regression analyses in muscle-invasive tumors.
Table S3 from Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3β
Authors: Lau Wen Min , Teng Eileen , Huang Kie Kyon , Tan Jin Wei , Das Kakoli , Zang Zhijiang , Chia Tania , Teh Ming , Kono Koji , Yong Wei Peng , Shabbir Asim , Tay Amy , Phua Niam Sin , Tan Patrick , Chan Shing Leng , So Jimmy Bok Yan
Published: April 2023

Amplified chromosomal regions in GAGA samples
Table S1 from A CRISPR/Cas9–Based Screening for Non-Homologous End Joining Inhibitors Reveals Ouabain and Penfluridol as Radiosensitizers
Authors: Du Jie , Shang Jun , Chen Fei , Zhang Yushuo , Yin Narui , Xie Ting , Zhang Haowen , Yu Jiahua , Liu Fenju
Published: April 2023

Full table of the screening results.
Figure S4 from Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3β
Authors: Lau Wen Min , Teng Eileen , Huang Kie Kyon , Tan Jin Wei , Das Kakoli , Zang Zhijiang , Chia Tania , Teh Ming , Kono Koji , Yong Wei Peng , Shabbir Asim , Tay Amy , Phua Niam Sin , Tan Patrick , Chan Shing Leng , So Jimmy Bok Yan
Published: April 2023

Expression of PKC isoforms after inhibition by PKC inhibitor H7.
Figure S3 from Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3β
Authors: Lau Wen Min , Teng Eileen , Huang Kie Kyon , Tan Jin Wei , Das Kakoli , Zang Zhijiang , Chia Tania , Teh Ming , Kono Koji , Yong Wei Peng , Shabbir Asim , Tay Amy , Phua Niam Sin , Tan Patrick , Chan Shing Leng , So Jimmy Bok Yan
Published: April 2023

Immunoblot and Annexin V assays of GAGA6 and GAGA6-R PDX tumors after drug treatment with AZD4547, sunitinib or 1-AKP.
Figure S1 from Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth
Authors: Harada Takeshi , Matsumoto Shinji , Hirota Suguru , Kimura Hirokazu , Fujii Shinsuke , Kasahara Yuuya , Gon Hidetoshi , Yoshida Toshihiko , Itoh Tomoo , Haraguchi Naotsugu , Mizushima Tsunekazu , Noda Takehiro , Eguchi Hidetoshi , Nojima Satoshi , Morii Eiichi , Fukumoto Takumi , Obika Satoshi , Kikuchi Akira
Published: April 2023

ARL4C mRNA levels in HCC and CRC.
Figures S1-S6 from Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer
Authors: Palisoul Marguerite L. , Quinn Jeanne M. , Schepers Emily , Hagemann Ian S. , Guo Lei , Reger Kelsey , Hagemann Andrea R. , McCourt Carolyn K. , Thaker Premal H. , Powell Matthew A. , Mutch David G. , Fuh Katherine C.
Published: April 2023

All supplemental figures (S1-S6).
Figure S7 from Acquired JHDM1D–BRAF Fusion Confers Resistance to FGFR Inhibition in FGFR2-Amplified Gastric Cancer
Authors: Sase Hitoshi , Nakanishi Yoshito , Aida Satoshi , Horiguchi-Takei Kana , Akiyama Nukinori , Fujii Toshihiko , Sakata Kiyoaki , Mio Toshiyuki , Aoki Masahiro , Ishii Nobuya
Published: April 2023

Cell growth inhibition evaluated by 3D spheroid assay.
Figure S5 from Androgen Receptor Inhibitor Enhances the Antitumor Effect of PARP Inhibitor in Breast Cancer Cells by Modulating DNA Damage Response
Authors: Min Ahrum , Jang Hyemin , Kim Seongyeong , Lee Kyung-Hun , Kim Debora Keunyoung , Suh Koung Jin , Yang Yaewon , Elvin Paul , O'Connor Mark J. , Im Seock-Ah
Published: April 2023

The protein expression levels of NKX3.1 and genetic alterations of NKX3.1 among breast cancer cell lines
Supplementary Figures 1-8 from Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions
Authors: Floc'h Nicolas , Martin Matthew J. , Riess Jonathan W. , Orme Jonathan P. , Staniszewska Anna D. , Ménard Ludovic , Cuomo Maria Emanuela , O'Neill Daniel J. , Ward Richard A. , Finlay M. Raymond V. , McKerrecher Darren , Cheng Mingshan , Vang Daniel P. , Burich Rebekah A. , Keck James G. , Gandara David R. , Mack Philip C. , Cross Darren A.E.
Published: April 2023

Supplementary figure 1: Generation of H2073 ASV and H2073 SVD. Supplementary figure 2: H2073 parental and Ex20Ins are dependent on EGFR for survival in vitro. Supplementary figure 3: Effect of TKI on the Sytox Proliferation of H2073 wt, H2073-SVD and H2073-ASV, in vitro. Supplementary figure 4: The H2073 parental NSCLC xenograft model is sensitive to afatinib in vivo. Supplementary figure 5: Osimertinib and AZ5104 given as monotherapy induce robust inhibition of p-EGFR and relevant downstream signalling pathways. Supplementary figure 6: Osimertinib and AZ5104 as monotherapy induce a strong inhibition of the level of pEGFR and the downstream signalling pathways. Supplementary figure 7: Osimertinib, AZ5104, afatinib and erlotinib are well tolerated at the dose explored in the PDX models and AZ5104 induce significant tumor growth inhibition in the LU0387 model when dosed at 50 mg/kg. Supplementary figure 8: Osimertinib, afatinib and erlotinib robustly inhibit pEGFR; however, select proteins representing downstream signalling pathways (pAKT) have enhanced inhibition to osimertinib and pS6R remains suppressed at early timepoints compared to afatinib and erlotinib in the UC Davis PDX model harboring the V769_D770InsASV.
Supplementary Figures 1-3 from Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab
Authors: Kurdi Ahmed T. , Glavey Siobhan V. , Bezman Natalie A. , Jhatakia Amy , Guerriero Jennifer L. , Manier Salomon , Moschetta Michele , Mishima Yuji , Roccaro Aldo , Detappe Alexandre , Liu Chia-Jen , Sacco Antonio , Huynh Daisy , Tai Yu-Tzu , Robbins Michael D. , Azzi Jamil , Ghobrial Irene M.
Published: April 2023

Supplementary Figure 1. In-vivo mouse model's schema; Supplementary Figure 2. Total BLI Flux of SCID.beige myeloma xenograft model and Kaplan-Meier survival analysis of the NSG xenograft model; Supplementary Figure 3. Elotuzumab does not affect myeloma cell proliferation and homing to the bone marrow.
Supplementary Methods from Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody–Drug Conjugates
Authors: Neumann Christopher S. , Olivas Kathleen C. , Anderson Martha E. , Cochran Julia H. , Jin Steven , Li Fu , Loftus Luke V. , Meyer David W. , Neale Jason , Nix Jay C. , Pittman Paul G. , Simmons Jessica K. , Ulrich Michelle L. , Waight Andrew B. , Wong Abbie , Zaval Margo C. , Zeng Weiping , Lyon Robert P. , Senter Peter D.
Published: April 2023

Detailed methods for ADC analytics and chemical sysnthesis
Figure S1 from TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell–Mediated Regression of Pancreatic Cancer
Authors: Principe Daniel R. , Park Alex , Dorman Matthew J. , Kumar Sandeep , Viswakarma Navin , Rubin Jonathan , Torres Carolina , McKinney Ronald , Munshi Hidayatullah G. , Grippo Paul J. , Rana Ajay
Published: April 2023

Figure S1 shows that T-cell deficiency of TGFBR1 promotes an immune response against established pancreatic neoplasms. Interestingly, this was not recapitulated via systemic reduction of TGFBR1.
Supplementary Figure 2 from Oncolytic Herpes Virus Armed with Vasculostatin in Combination with Bevacizumab Abrogates Glioma Invasion via the CCN1 and AKT Signaling Pathways
Authors: Tomita Yusuke , Kurozumi Kazuhiko , Yoo Ji Young , Fujii Kentaro , Ichikawa Tomotsugu , Matsumoto Yuji , Uneda Atsuhito , Hattori Yasuhiko , Shimizu Toshihiko , Otani Yoshihiro , Oka Tetsuo , Kaur Balveen , Date Isao
Published: April 2023

Supplementary Figure 2 shows In vitro scratch migration assay.
Figure S4 from Mechanisms of Entrectinib Resistance in a Neuroblastoma Xenograft Model
Authors: MacFarland Suzanne P. , Naraparaju Koumudi , Iyer Radhika , Guan Peng , Kolla Venkatadri , Hu Yuxuan , Tan Kai , Brodeur Garrett M.
Published: April 2023

Figure 4-5 densiometry including error bars and asterisks to indicate statistical significance (alpha <0.05)
Supplementary Figure S5 from IL15-Based Trifunctional Antibody-Fusion Proteins with Costimulatory TNF-Superfamily Ligands in the Single-Chain Format for Cancer Immunotherapy
Authors: Beha Nadine , Harder Markus , Ring Sarah , Kontermann Roland E. , Müller Dafne
Published: April 2023

Treg response
Supplementary Figure S4 from IL15-Based Trifunctional Antibody-Fusion Proteins with Costimulatory TNF-Superfamily Ligands in the Single-Chain Format for Cancer Immunotherapy
Authors: Beha Nadine , Harder Markus , Ring Sarah , Kontermann Roland E. , Müller Dafne
Published: April 2023

Proliferation and composition of CD8+ and CD4+ T cells
Figure S1 from Mechanisms of Entrectinib Resistance in a Neuroblastoma Xenograft Model
Authors: MacFarland Suzanne P. , Naraparaju Koumudi , Iyer Radhika , Guan Peng , Kolla Venkatadri , Hu Yuxuan , Tan Kai , Brodeur Garrett M.
Published: April 2023

IC50 for resistant cell lines as compared to IC50 of parental cell line
Supplementary Figure S3 from IL15-Based Trifunctional Antibody-Fusion Proteins with Costimulatory TNF-Superfamily Ligands in the Single-Chain Format for Cancer Immunotherapy
Authors: Beha Nadine , Harder Markus , Ring Sarah , Kontermann Roland E. , Müller Dafne
Published: April 2023

Binding analysis by flow cytometry
Supplementary Figure S2 from IL15-Based Trifunctional Antibody-Fusion Proteins with Costimulatory TNF-Superfamily Ligands in the Single-Chain Format for Cancer Immunotherapy
Authors: Beha Nadine , Harder Markus , Ring Sarah , Kontermann Roland E. , Müller Dafne
Published: April 2023

Representative figures of flow cytometry analysis
Figure S1 from Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA-E545K Mutation
Authors: Jiang Wei , Wu Yutuan , He Tiancong , Zhu Hanting , Ke Guihao , Xiang Libing , Yang Huijuan
Published: April 2023

The expression level of GSK3β/β-catenin in SiHa and MS751 cells with PIK3CA-WT and E545K after 4Gy of IR exposure pretreated with AKT inhibitor for 24h.
Supplementary Table I from Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097
Authors: Weisberg Ellen , Halilovic Ensar , Cooke Vesselina G. , Nonami Atsushi , Ren Tao , Sanda Takaomi , Simkin Irene , Yuan Jing , Antonakos Brandon , Barys Louise , Ito Moriko , Stone Richard , Galinsky Ilene , Cowens Kristen , Nelson Erik , Sattler Martin , Jeay Sebastien , Wuerthner Jens U. , McDonough Sean M. , Wiesmann Marion , Griffin James D.
Published: April 2023

Supplementary Table I. AML patient information.
Supplementary Figure Legends from Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097
Authors: Weisberg Ellen , Halilovic Ensar , Cooke Vesselina G. , Nonami Atsushi , Ren Tao , Sanda Takaomi , Simkin Irene , Yuan Jing , Antonakos Brandon , Barys Louise , Ito Moriko , Stone Richard , Galinsky Ilene , Cowens Kristen , Nelson Erik , Sattler Martin , Jeay Sebastien , Wuerthner Jens U. , McDonough Sean M. , Wiesmann Marion , Griffin James D.
Published: April 2023

Supplementary Figure Legends
Supplementary Figure 4 from Seribantumab, an Anti-ERBB3 Antibody, Delays the Onset of Resistance and Restores Sensitivity to Letrozole in an Estrogen Receptor–Positive Breast Cancer Model
Authors: Curley Michael D. , Sabnis Gauri J. , Wille Lucia , Adiwijaya Bambang S. , Garcia Gabriela , Moyo Victor , Kazi Armina A. , Brodie Angela , MacBeath Gavin
Published: April 2023

Statistical analyses of tumor growth curves in mouse study 2 (Figure 5)
Supplementary Methods from HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors
Authors: Proia David A. , Smith Donald L. , Zhang Junyi , Jimenez John-Paul , Sang Jim , Ogawa Luisa Shin , Sequeira Manuel , Acquaviva Jaime , He Suqin , Zhang Chaohua , Khazak Vladimir , Astsaturov Igor , Inoue Takayo , Tatsuta Noriaki , Osman Sami , Bates Richard C. , Chimmanamada Dinesh , Ying Weiwen
Published: April 2023

Plasma stability assay
Supplementary Figure Legends from HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors
Authors: Proia David A. , Smith Donald L. , Zhang Junyi , Jimenez John-Paul , Sang Jim , Ogawa Luisa Shin , Sequeira Manuel , Acquaviva Jaime , He Suqin , Zhang Chaohua , Khazak Vladimir , Astsaturov Igor , Inoue Takayo , Tatsuta Noriaki , Osman Sami , Bates Richard C. , Chimmanamada Dinesh , Ying Weiwen
Published: April 2023

Supplementary Figure Legends
Figure S2 from HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors
Authors: Proia David A. , Smith Donald L. , Zhang Junyi , Jimenez John-Paul , Sang Jim , Ogawa Luisa Shin , Sequeira Manuel , Acquaviva Jaime , He Suqin , Zhang Chaohua , Khazak Vladimir , Astsaturov Igor , Inoue Takayo , Tatsuta Noriaki , Osman Sami , Bates Richard C. , Chimmanamada Dinesh , Ying Weiwen
Published: April 2023

Relative levels of SN-38 released from STA-12-8666 or irinotecan by recombinant carboxylesterases (CES) in vitro.
Figure S1 from HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors
Authors: Proia David A. , Smith Donald L. , Zhang Junyi , Jimenez John-Paul , Sang Jim , Ogawa Luisa Shin , Sequeira Manuel , Acquaviva Jaime , He Suqin , Zhang Chaohua , Khazak Vladimir , Astsaturov Igor , Inoue Takayo , Tatsuta Noriaki , Osman Sami , Bates Richard C. , Chimmanamada Dinesh , Ying Weiwen
Published: April 2023

HSP90 binding promotes the intracellular retention of HSP90 inhibitor-BODIPY probes in tumor cell lines.
Supplementary Figure S3 from The RNA-Binding Protein HuR Confers Oxaliplatin Resistance of Colorectal Cancer By Upregulating CDC6
Authors: Cai Jian , Wang Huaiming , Jiao Xiaodong , Huang Rongkang , Qin Qiyuan , Zhang Jianwei , Chen Honglei , Feng Dan , Tian Xin , Wang Hui
Published: April 2023

CDC6 confers resistance to L-OHP-induced apoptosis of CRC cells.
Supplementary Figure S2 from The RNA-Binding Protein HuR Confers Oxaliplatin Resistance of Colorectal Cancer By Upregulating CDC6
Authors: Cai Jian , Wang Huaiming , Jiao Xiaodong , Huang Rongkang , Qin Qiyuan , Zhang Jianwei , Chen Honglei , Feng Dan , Tian Xin , Wang Hui
Published: April 2023

TMA-CDC6 expression by IHC.
Table S4 from Monoclonal Antibody Targeting Sialyl-di-Lewisa–Containing Internalizing and Noninternalizing Glycoproteins with Cancer Immunotherapy Development Potential
Authors: Tivadar Silvana T. , McIntosh Richard S. , Chua Jia Xin , Moss Robert , Parsons Tina , Zaitoun Abed M. , Madhusudan Srinivasan , Durrant Lindy G. , Vankemmelbeke Mireille
Published: April 2023

Overview of EC50 values for in vitro cytotoxicity of CH129-ADC compounds
Figure S3 from Reduction of Muscle-Invasive Tumors by Photodynamic Therapy with Tetrahydroporphyrin-Tetratosylat in an Orthotopic Rat Bladder Cancer Model
Authors: Berndt-Paetz Mandy , Schulze Philipp , Stenglein Philipp C. , Weimann Annett , Wang Qiang , Horn Lars-Christian , Riyad Yasser M. , Griebel Jan , Hermann Ralf , Glasow Annegret , Stolzenburg Jens-Uwe , Neuhaus Jochen
Published: April 2023

Figure S3 shows bladder evaluation exemplarily.
Table S2 from Monoclonal Antibody Targeting Sialyl-di-Lewisa–Containing Internalizing and Noninternalizing Glycoproteins with Cancer Immunotherapy Development Potential
Authors: Tivadar Silvana T. , McIntosh Richard S. , Chua Jia Xin , Moss Robert , Parsons Tina , Zaitoun Abed M. , Madhusudan Srinivasan , Durrant Lindy G. , Vankemmelbeke Mireille
Published: April 2023

Glycan array results for FG129
Figure S2 from Reduction of Muscle-Invasive Tumors by Photodynamic Therapy with Tetrahydroporphyrin-Tetratosylat in an Orthotopic Rat Bladder Cancer Model
Authors: Berndt-Paetz Mandy , Schulze Philipp , Stenglein Philipp C. , Weimann Annett , Wang Qiang , Horn Lars-Christian , Riyad Yasser M. , Griebel Jan , Hermann Ralf , Glasow Annegret , Stolzenburg Jens-Uwe , Neuhaus Jochen
Published: April 2023

Figure S2 shows optimization of light dose used for PDT.
Figure S1 from Reduction of Muscle-Invasive Tumors by Photodynamic Therapy with Tetrahydroporphyrin-Tetratosylat in an Orthotopic Rat Bladder Cancer Model
Authors: Berndt-Paetz Mandy , Schulze Philipp , Stenglein Philipp C. , Weimann Annett , Wang Qiang , Horn Lars-Christian , Riyad Yasser M. , Griebel Jan , Hermann Ralf , Glasow Annegret , Stolzenburg Jens-Uwe , Neuhaus Jochen
Published: April 2023

Figure S1 shows immunohistochemical characterization of AY-27 cells.
Table S1 from Plk1 Inhibition Enhances the Efficacy of BET Epigenetic Reader Blockade in Castration-Resistant Prostate Cancer
Authors: Mao Fengyi , Li Jie , Luo Qian , Wang Ruixin , Kong Yifan , Carlock Colin , Liu Zian , Elzey Bennet D. , Liu Xiaoqi
Published: April 2023

IC50 of 22RV1 cells
Figure S3 from Plk1 Inhibition Enhances the Efficacy of BET Epigenetic Reader Blockade in Castration-Resistant Prostate Cancer
Authors: Mao Fengyi , Li Jie , Luo Qian , Wang Ruixin , Kong Yifan , Carlock Colin , Liu Zian , Elzey Bennet D. , Liu Xiaoqi
Published: April 2023

IF staining for PD-L1
Supplementary Fig S1 from A Multifunctional Therapy Approach for Cancer: Targeting Raf1- Mediated Inhibition of Cell Motility, Growth, and Interaction with the Microenvironment
Authors: Zhang Limin , Pattanayak Abhinandan , Li Wenqi , Ko Hyun-Kyung , Fowler Graham , Gordon Ryan , Bergan Raymond
Published: April 2023

Supplementary Fig S1 shows that KBU2046 does not interfere with chemotherapy efficacy
Supplemental Figure 1 from The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor
Authors: Lemberg Kathryn M. , Zhao Liang , Wu Ying , Veeravalli Vijayabhaskar , Alt Jesse , Aguilar Joanna Marie H. , Dash Ranjeet P. , Lam Jenny , Tenora Lukáš , Rodriguez Chabely , Nedelcovych Michael T. , Brayton Cory , Majer Pavel , Blakeley Jaishri O. , Rais Rana , Slusher Barbara S.
Published: April 2023

Supplemental Figure 1: JHU395 and DON treatment of sNF02.2 MPNST cells, evaluation of PARP cleavage following JHU395 treatment in sNF96.2 cells, and effects of DON and JHU395 on oxygen consumption rates in sNF96.2 MPNST cells.
Supplemental figure 4 from Antitumor Effects of MEHD7945A, a Dual-Specific Antibody against EGFR and HER3, in Combination with Radiation in Lung and Head and Neck Cancers
Authors: Li Chunrong , Huang Shyhmin , Armstrong Eric A. , Francis David M. , Werner Lauryn R. , Sliwkowski Mark X. , van der Kogel Albert , Harari Paul M.
Published: April 2023

The anti-tumor effects of MEHD7945A and single fraction radiation in NCI-H226 xenografts.
Supplemental figure 3 from Antitumor Effects of MEHD7945A, a Dual-Specific Antibody against EGFR and HER3, in Combination with Radiation in Lung and Head and Neck Cancers
Authors: Li Chunrong , Huang Shyhmin , Armstrong Eric A. , Francis David M. , Werner Lauryn R. , Sliwkowski Mark X. , van der Kogel Albert , Harari Paul M.
Published: April 2023

Kaplan Meier survival curves of UM-SCC6, SCC1483 and NCI-H226 xenografts treated with MEHD7945A in combination with radiation.
Supplementary Materials and Methods and Supplementary Figures 1 through 7 from Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs
Authors: Tsukamoto Shuntaro , Huang Yuhui , Kumazoe Motofumi , Lesnick Connie , Yamada Shuhei , Ueda Naoki , Suzuki Takashi , Yamashita Shuya , Kim Yoon Hee , Fujimura Yoshinori , Miura Daisuke , Kay Neil E. , Shanafelt Tait D. , Tachibana Hirofumi
Published: April 2023

This supplementary material contains supplemental materials and methods used in the supplemental result and 7 supplemental figures. The supplemental figures are related as below: Supplementary Figure S1. showed Multi-RTKs activities in MM cells. Supplementary Figure S2. showed the effect of safingol on EGCG-induced ceramide-rich lipid raft clustering. Supplementary Figure S3. showed the effect of safingol on EGCG-induced ceramide accumulation. Supplementary Figure S4. showed EGCG/safingol in combination inhibits the growth of U266 cells cells. Supplementary Figure S5. showed the effect of SphK2 on the EGCG-induced apoptosis in U266 cells. Supplementary Figure S6. showed the effect of Ro 31-8220 on EGCG-induced apoptosis in U266 cells. Supplementary Figure S7. showed the toxicity of EGCG/Safingol combination on tumor growth in vivo.
Supplemental figure 1 from Met Signaling Cascade Is Amplified by the Recruitment of Phosphorylated Met to Lipid Rafts via CD24 and Leads to Drug Resistance in Endometrial Cancer Cell Lines
Authors: Ono Yoshihiro Joshua , Tanabe Akiko , Tanaka Tomohito , Tanaka Yoshimichi , Hayashi Masami , Terai Yoshito , Ohmichi Masahide
Published: April 2023

Confirmation of CD24 knockdown in CD24 siRNA transfected cells
Supplementary Figure 3 from Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages
Authors: Iwanowycz Stephen , Wang Junfeng , Hodge Johnie , Wang Yuzhen , Yu Fang , Fan Daping
Published: April 2023

Emodin treatment increases T cell activation
Supplemental Figure 1 from Combining Chk1/2 Inhibition with Cetuximab and Radiation Enhances In Vitro and In Vivo Cytotoxicity in Head and Neck Squamous Cell Carcinoma
Authors: Zeng Ling , Beggs Reena R. , Cooper Tiffiny S. , Weaver Alice N. , Yang Eddy S.
Published: April 2023

Supplemental Figure S1. Colony formation and cell proliferation assays in UM-SCC1 and UM-SCC47
Supplementary Figure 3 from Improved Tumor-Specific Drug Accumulation by Polymer Therapeutics with pH-Sensitive Drug Release Overcomes Chemotherapy Resistance
Authors: Heinrich Anne-Kathrin , Lucas Henrike , Schindler Lucie , Chytil Petr , Etrych Tomáš , Mäder Karsten , Mueller Thomas
Published: April 2023

Survival plot (Kaplan-Meier) for the therapy study with 1411HP tumor-bearing mice. Cum. survival of mice under respective therapy (PBS, free Dox, pHPMA-Dox conjugate and pHPMA precursor) is displayed.
Suppl. Figure 2 from Upregulation of AKT3 Confers Resistance to the AKT Inhibitor MK2206 in Breast Cancer
Authors: Stottrup Casey , Tsang Tiffany , Chin Y. Rebecca
Published: April 2023

Knockdown of AKT1 or AKT2 does not sensitizes AKTi-resistant breast tumor cells to MK2206.
Suppl. Figure 1 from Upregulation of AKT3 Confers Resistance to the AKT Inhibitor MK2206 in Breast Cancer
Authors: Stottrup Casey , Tsang Tiffany , Chin Y. Rebecca
Published: April 2023

Upregulation of AKT3, but not AKT1 or AKT2, in AKT inhibitor-resistant MDA-MB-468 breast tumor cells.
Supplementary Table 4 from Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib
Authors: Miller Rowan E. , Brough Rachel , Bajrami Ilirjana , Williamson Chris T. , McDade Simon , Campbell James , Kigozi Asha , Rafiq Rumana , Pemberton Helen , Natrajan Rachel , Joel Josephine , Astley Holly , Mahoney Claire , Moore Jonathan D. , Torrance Chris , Gordan John D. , Webber James T. , Levin Rebecca S. , Shokat Kevan M. , Bandyopadhyay Sourav , Lord Christopher J. , Ashworth Alan
Published: April 2023

siRNA library gene list for dasatinib resistance screen, see also figure 5
Table S2 from TTK Inhibitors as a Targeted Therapy for CTNNB1 (β-catenin) Mutant Cancers
Authors: Zaman Guido J.R. , de Roos Jeroen A.D.M. , Libouban Marion A.A. , Prinsen Martine B.W. , de Man Jos , Buijsman Rogier C. , Uitdehaag Joost C.M.
Published: April 2023

Reanalyis of cell panel profilings of TTK inhibitors from literature
Supplementary Video S5. Interphase microtubule dynamics in HeLa-EB1-GFP treated with vinblastine (20 nM). from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
Authors: Levrier Claire , Sadowski Martin C. , Rockstroh Anja , Gabrielli Brian , Kavallaris Maria , Lehman Melanie , Davis Rohan A. , Nelson Colleen C.
Published: April 2023

EB1-GFP was imaged by spinning disk microscopy (2 images/s for 2 min). EB1 comets appeared faint and followed irregular and short trajectories. Scale bar=10 Âµm.
Table S1 from Macrophage Susceptibility to Emactuzumab (RG7155) Treatment
Authors: Pradel Leon P. , Ooi Chia-Huey , Romagnoli Solange , Cannarile Michael A. , Sade Hadassah , Rüttinger Dominik , Ries Carola H.
Published: April 2023

Information on primer sequences and conditions used for subsequent RT-PCR
Supplementary Data Set from N-Arachidonoyl Dopamine Inhibits NRAS Neoplastic Transformation by Suppressing Its Plasma Membrane Translocation
Authors: Wu Min , Huang Jinyan , Zhang Jianming , Benes Cyril , Jiao Bo , Ren Ruibao
Published: April 2023

Unique genes differentially expressed between 1μM NADA and vehicle control treated Ba/F3-N cells.
Supplemental Figure 2 from Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma
Authors: Haak Andrew J. , Appleton Kathryn M. , Lisabeth Erika M. , Misek Sean A. , Ji Yajing , Wade Susan M. , Bell Jessica L. , Rockwell Cheryl E. , Airik Merlin , Krook Melanie A. , Larsen Scott D. , Verhaegen Monique , Lawlor Elizabeth R. , Neubig Richard R.
Published: April 2023

To show that MRTF-A localization was dependent on F-actin dynamics, we stimulated SK-Mel-19 cells with 20% FBS to induce stress fiber formation which induced MRTF-A nuclear localization. We also treated SK-Mel-147 cells with latrunculin B which inhibits F-actin formation and MRTF-A relocated to the cytosol.
Table S1 from Circulating Tumor Cells with Stemness and Epithelial-to-Mesenchymal Transition Features Are Chemoresistant and Predictive of Poor Outcome in Metastatic Breast Cancer
Authors: Papadaki Maria A. , Stoupis Giannis , Theodoropoulos Panayiotis A. , Mavroudis Dimitris , Georgoulias Vassilis , Agelaki Sofia
Published: April 2023

Table S1 shows the associations between the different clinicopathological parameters and the detection of CTCs and CTC phenotypes at baseline. In the HER2-positive setting, the detection of CK+ CTCs was associated with Grade III tumor status; no correlation was observed between the presence of different CTC subsets and clinicopathological parameters. Among HER2-negative patients, the detection of CK+CTCs was correlated to LN and lung metastases; patients with LN metastases more frequently harbored non-CSC+/epithelial-like CTCs, whereas in those with lung metastases, CSC+/partial-EMT+ CTCs were mainly identified. All the associations were investigated by Chi-square two-sided tests.
Supplementary Material, figures 1-3 from 15α-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models
Authors: Hilliard Tyvette S. , Miklossy Gabriella , Chock Christopher , Yue Peibin , Williams Philip , Turkson James
Published: April 2023

Supplementary Figure S1. Phase-contrast microscopy imaging of cellular morphology of tumor cells after treatment with 15α-MP; Supplementary Figure S2. Global phospho-protein expression in U251MG cells and the changes induced in response to treatment with 15α-MP; Supplementary Figure S3. Immunoprecipitation and immunoblotting analyses of estrogen receptor (ER) α and Stat3
Figure S1 from A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis
Authors: Galbán Stefanie , Apfelbaum April A. , Espinoza Carlos , Heist Kevin , Haley Henry , Bedi Karan , Ljungman Mats , Galbán Craig J. , Luker Gary D. , Dort Marcian Van , Ross Brian D.
Published: April 2023

Supplemental Figure 1
Supplementary Figure 6 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Authors: Jones Dylan T. , Valli Alessandro , Haider Syed , Zhang Qifeng , Smethurst Elizabeth A. , Schug Zachary T. , Peck Barrie , Aboagye Eric O. , Critchlow Susan E. , Schulze Almut , Gottlieb Eyal , Wakelam Michael J.O. , Harris Adrian L.
Published: April 2023

Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. ACC and B. PDHK inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within each family are sorted by name.
Supplementary data from Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells
Authors: Calgani Alessia , Vignaroli Giulia , Zamperini Claudio , Coniglio Federica , Festuccia Claudio , Di Cesare Ernesto , Gravina Giovanni Luca , Mattei Claudia , Vitale Flora , Schenone Silvia , Botta Maurizio , Angelucci Adriano
Published: April 2023

Supplementary table s1 + supplementary methods
Supplementary Figure 4 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Authors: Jones Dylan T. , Valli Alessandro , Haider Syed , Zhang Qifeng , Smethurst Elizabeth A. , Schug Zachary T. , Peck Barrie , Aboagye Eric O. , Critchlow Susan E. , Schulze Almut , Gottlieb Eyal , Wakelam Michael J.O. , Harris Adrian L.
Published: April 2023

Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within each family are sorted by name.
Supplementary Table S1 from Combining Nonclinical Experiments with Translational PKPD Modeling to Differentiate Erlotinib and Gefitinib
Authors: Eigenmann Miro J. , Frances Nicolas , Hoffmann Gerhard , Lavé Thierry , Walz Antje-Christine
Published: April 2023

Tabular representation of the experimental settings for the short- and long term experiments.
Supplementary Figure 2 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Authors: Jones Dylan T. , Valli Alessandro , Haider Syed , Zhang Qifeng , Smethurst Elizabeth A. , Schug Zachary T. , Peck Barrie , Aboagye Eric O. , Critchlow Susan E. , Schulze Almut , Gottlieb Eyal , Wakelam Michael J.O. , Harris Adrian L.
Published: April 2023

Two dimensional CyQuant cell proliferation assay of (A) MDA-MB-468 and (B) PC3 cells following 3 days of treatment under normoxic and hypoxic conditions with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K, Akt and mTOR. Results were plotted in triplicate, errors bars represent standard deviation and GI50 values were calculated using Graph Prism.
Supplementary Figure S6 from Combining Nonclinical Experiments with Translational PKPD Modeling to Differentiate Erlotinib and Gefitinib
Authors: Eigenmann Miro J. , Frances Nicolas , Hoffmann Gerhard , Lavé Thierry , Walz Antje-Christine
Published: April 2023

Displays the goodness of fit plots when fitting the PKPD model to tumor growth inhibition data in the cell line derived A431 xenografts.
Supplementary Figure 1 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Authors: Jones Dylan T. , Valli Alessandro , Haider Syed , Zhang Qifeng , Smethurst Elizabeth A. , Schug Zachary T. , Peck Barrie , Aboagye Eric O. , Critchlow Susan E. , Schulze Almut , Gottlieb Eyal , Wakelam Michael J.O. , Harris Adrian L.
Published: April 2023

Chemical structure of drugs that inhibit metabolic enzymes FASN (AZ22), ACC (AZ52), DGAT (AZ17), PDHK (AZ30), and cell signalling kinase enzymes PI3K (AZ46), AKT (AZ28) and mTOR (AZ64).
Supplementary Table 2 from Combining ABCG2 Inhibitors with IMMU-132, an Anti–Trop-2 Antibody Conjugate of SN-38, Overcomes Resistance to SN-38 in Breast and Gastric Cancers
Authors: Chang Chien-Hsing , Wang Yang , Zalath Maria , Liu Donglin , Cardillo Thomas M. , Goldenberg David M.
Published: April 2023

Functional activity of ABCB1 shown for HCT15, but not for NCI-N87 or NCI-N87-S120
Supplementary Figure S1 from Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins
Authors: Awuah Prince , Bera Tapan K. , Folivi Messan , Chertov Oleg , Pastan Ira
Published: April 2023

Flow cytometry analysis using 5 μg/ml of MSLN antibody showing that wild-type and TACE mutant cells express similar levels of surface MSLN.
Supplementary Figures S1-S7 from Targeted Treatment of Metastatic Breast Cancer by PLK1 siRNA Delivered by an Antioxidant Nanoparticle Platform
Authors: Morry Jingga , Ngamcherdtrakul Worapol , Gu Shenda , Reda Moataz , Castro David J. , Sangvanich Thanapon , Gray Joe W. , Yantasee Wassana
Published: April 2023

Supplementary Figure S1: Mesoporous silica-based nanoconstruct for targeted delivery of siRNA; Supplementary Figure S2: Screening of siPLK1 by mRNA knockdown and viability; Supplementary Figure S3: ROS intensity and NOX1-5 mRNA levels of TNBC cell lines; Supplementary Figure S4: HER2 signaling in LM2-4luc+/H2N cells; Supplementary Figure S5: Representative whole body bioluminescent IVIS imaging of a mouse injected with cancer cells; Supplementary Figure S6: Representative images of lung nodes of mice from short-term study; Supplementary Figure S7: Representative images of the whole lung, H&E, and anti-human vimentin staining of mouse lungs from the long-term study.
Supplementary Figures from Inhibition of the V-ATPase by Archazolid A: A New Strategy to Inhibit EMT
Authors: Merk Henriette , Messer Philipp , Ardelt Maximilian A. , Lamb Don C. , Zahler Stefan , Müller Rolf , Vollmar Angelika M. , Pachmayr Johanna
Published: April 2023

Supplementary Figure 1: Epithelial-mesenchymal transition in HMLE Twist1-ER cells; Supplementary Figure 3: Archazolid A does not induce apoptosis in HMLE Twist1-ER cells;Supplementary Figure 2: Archazolid A inhibits V-ATPase activity of HMLE Twist1-ER cells; Supplementary Figure 4: Archazolid A does not influence self-renewal markers Sox2 and OCT-4;Supplementary Figure 5: Archazolid A does not influence EMT markers at mRNA level; Supplementary Figure 6: Vesicle Tracking
Figure S5 from Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis
Authors: Zanotto-Filho Alfeu , Masamsetti V. Pragathi , Loranc Eva , Tonapi Sonal S. , Gorthi Aparna , Bernard Xavier , Gonçalves Rosângela Mayer , Moreira José C.F. , Chen Yidong , Bishop Alexander J.R.
Published: April 2023

Descriptive panel of hot-spot mutations in NFE2L2 and KEAP1 genes across lung and head and neck carcinoma samples available in the TCGA database (Provisional datasets) as obtained from the "Mutations" tool available in the TCGA cBioportal
Figure S3 from Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis
Authors: Zanotto-Filho Alfeu , Masamsetti V. Pragathi , Loranc Eva , Tonapi Sonal S. , Gorthi Aparna , Bernard Xavier , Gonçalves Rosângela Mayer , Moreira José C.F. , Chen Yidong , Bishop Alexander J.R.
Published: April 2023

Relative expression of classical NRF2 targets in high-, medium- and low-risk lung and head and neck carcinomas; ranked frequency of genetic alterations in NFE2L2 and KEAP1 genes across cancers in the TCGA database
Figure S1 from Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis
Authors: Zanotto-Filho Alfeu , Masamsetti V. Pragathi , Loranc Eva , Tonapi Sonal S. , Gorthi Aparna , Bernard Xavier , Gonçalves Rosângela Mayer , Moreira José C.F. , Chen Yidong , Bishop Alexander J.R.
Published: April 2023

Pathway Enrichment Analysis and MMS-induced fold changes in target genes of DNA damage response pathways.
Supplementary Figure S4 from β-Catenin Inhibitor BC2059 Is Efficacious as Monotherapy or in Combination with Proteasome Inhibitor Bortezomib in Multiple Myeloma
Authors: Savvidou Ioanna , Khong Tiffany , Cuddihy Andrew , McLean Catriona , Horrigan Stephen , Spencer Andrew
Published: April 2023

Expression of TBL1 in HMCL.
Supplemental Legends 1-6 from CDK4/6 Inhibitors Sensitize Rb-positive Sarcoma Cells to Wee1 Kinase Inhibition through Reversible Cell-Cycle Arrest
Authors: Francis Ashleigh M. , Alexander Angela , Liu Yanna , Vijayaraghavan Smruthi , Low Kwang Hui , Yang Dong , Bui Tuyen , Somaiah Neeta , Ravi Vinod , Keyomarsi Khandan , Hunt Kelly K.
Published: April 2023

This file includes the supplemental legends to the 6 different supplemental figures referred to in the manuscript
Figure S3 from Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI–Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation
Authors: Yamaoka Toshimitsu , Ohmori Tohru , Ohba Motoi , Arata Satoru , Kishino Yasunari , Murata Yasunori , Kusumoto Sojiro , Ishida Hiroo , Shirai Takao , Hirose Takashi , Ohnishi Tsukasa , Sasaki Yasutsuna
Published: April 2023

Met expression was partially attenuated by knockdown of Smad2/3, even when the expression of EGFR and IGF1R was attenuated by siRNA-mediated IGFBP3 knockdown.
Supplementary Figure 4 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb3/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Authors: Geyer Philipp Emanuel , Maak Matthias , Nitsche Ulrich , Perl Markus , Novotny Alexander , Slotta-Huspenina Julia , Dransart Estelle , Holtorf Anne , Johannes Ludger , Janssen Klaus-Peter
Published: April 2023

STxB retains binding capacity to Gb3 at low pH in St3051 cells
Supplementary Figure 3 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb3/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Authors: Geyer Philipp Emanuel , Maak Matthias , Nitsche Ulrich , Perl Markus , Novotny Alexander , Slotta-Huspenina Julia , Dransart Estelle , Holtorf Anne , Johannes Ludger , Janssen Klaus-Peter
Published: April 2023

Gb3-expression is down-regulated in senescent cancer cells (marked by SA-β-galactosidase)
Supplementary Figure 2 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb3/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Authors: Geyer Philipp Emanuel , Maak Matthias , Nitsche Ulrich , Perl Markus , Novotny Alexander , Slotta-Huspenina Julia , Dransart Estelle , Holtorf Anne , Johannes Ludger , Janssen Klaus-Peter
Published: April 2023

Gb3-expression during cell division and mitosis in GP220 gastric cancer cells
Supplementary Figure 1 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb3/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Authors: Geyer Philipp Emanuel , Maak Matthias , Nitsche Ulrich , Perl Markus , Novotny Alexander , Slotta-Huspenina Julia , Dransart Estelle , Holtorf Anne , Johannes Ludger , Janssen Klaus-Peter
Published: April 2023

A) Scoring system for STxB-staining B) Gb3 detection with/without cholesterol depletion C-D) Gb3 not upregulated in gastritis
Supplementary Figures 1-3 from Vulnerability of Small-Cell Lung Cancer to Apoptosis Induced by the Combination of BET Bromodomain Proteins and BCL2 Inhibitors
Authors: Lam Lloyd T. , Lin Xiaoyu , Faivre Emily J. , Yang Ziping , Huang Xiaoli , Wilcox Denise M. , Bellin Richard J. , Jin Sha , Tahir Stephen K. , Mitten Michael , Magoc Terry , Bhathena Anahita , Kati Warren M. , Albert Daniel H. , Shen Yu , Uziel Tamar
Published: April 2023

Suppl. Figure 1. Caspase inhibitor prevents caspase 3/7 activity; Suppl. Figure 2. Levels of BIM, BAD, BAX and BAK silencing by siRNA; Suppl. Figure 3. mRNA and protein expression of BCL2 and BCLxl upon treatment with ABBV-075.
Supplementary Figure S1 from Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic–Induced Apoptosis
Authors: Antonietti Patrick , Linder Benedikt , Hehlgans Stephanie , Mildenberger Iris C. , Burger Michael C. , Fulda Simone , Steinbach Joachim P. , Gessler Florian , Rödel Franz , Mittelbronn Michel , Kögel Donat
Published: April 2023

Anti-apoptotic function of BAG3 in U87 glioma cells.
Supplementary Figure Legends from Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic–Induced Apoptosis
Authors: Antonietti Patrick , Linder Benedikt , Hehlgans Stephanie , Mildenberger Iris C. , Burger Michael C. , Fulda Simone , Steinbach Joachim P. , Gessler Florian , Rödel Franz , Mittelbronn Michel , Kögel Donat
Published: April 2023

Supplementary Figure Legends
Supplemental Figure Legends from Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma
Authors: Gifford Jenifer B. , Huang Wei , Zeleniak Ann E. , Hindoyan Antreas , Wu Hong , Donahue Timothy R. , Hill Reginald
Published: April 2023

Figure legends for the supplemental table and each of the supplemental figures.
Supplementary Information from Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer
Authors: Machitani Mitsuhiro , Sakurai Fuminori , Wakabayashi Keisaku , Tachibana Masashi , Fujiwara Toshiyoshi , Mizuguchi Hiroyuki
Published: April 2023

Supplementary Fig. S1 Tumor cell lysis profiles of TRAD-shDicer in SK-OV-3 cells; Supplementary Table S1 The oligonucleotides and primers used in this study
Supplemental Figure 3 from Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma
Authors: Gifford Jenifer B. , Huang Wei , Zeleniak Ann E. , Hindoyan Antreas , Wu Hong , Donahue Timothy R. , Hill Reginald
Published: April 2023

Increased cell death with use of HSP70 family member inhibitor.
Supplementary Figure S6 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Authors: Li Xinzhe , Li Bo , Ni Zhenhong , Zhou Peng , Wang Bin , He Jintao , Xiong Haojun , Yang Fan , Wu Yaran , Lyu Xilin , Zhang Yan , Zeng Yijun , Lian Jiqin , He Fengtian
Published: April 2023

The influence of the cotreatment with metformin and ABT-263 on different translation-relevant kinase signaling pathways.
Supplementary Figure S5 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Authors: Li Xinzhe , Li Bo , Ni Zhenhong , Zhou Peng , Wang Bin , He Jintao , Xiong Haojun , Yang Fan , Wu Yaran , Lyu Xilin , Zhang Yan , Zeng Yijun , Lian Jiqin , He Fengtian
Published: April 2023

Metformin attenuates ABT-263-induced MCL-1, XIAP and SURVIVIN through neither transcriptional nor posttranslational regulation.
Supplementary methods from The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide
Authors: Prekovic Stefan , van Royen Martin E. , Voet Arnout R.D. , Geverts Bart , Houtman Rene , Melchers Diana , Zhang Kam Y.J. , Van den Broeck Thomas , Smeets Elien , Spans Lien , Houtsmuller Adriaan B. , Joniau Steven , Claessens Frank , Helsen Christine
Published: April 2023

Protocol of the cell viability assay performed on LAPC4 cells.
Figure S6 from Vessel-Targeted Chemophototherapy with Cationic Porphyrin-Phospholipid Liposomes
Authors: Luo Dandan , Geng Jumin , Li Nasi , Carter Kevin A. , Shao Shuai , Atilla-Gokcumen G. Ekin , Lovell Jonathan F.
Published: April 2023

Scar formation at the laser treated site in the Dox PoP/DOTAP liposomes+laser and empty PoP/DOTAP liposomes+laser group, but not PoP/DOPC liposomes+laser group, indicating stronger PDT effect from DOTAP liposomes compared to DOPC liposomes.
Figure S6 from Vessel-Targeted Chemophototherapy with Cationic Porphyrin-Phospholipid Liposomes
Authors: Luo Dandan , Geng Jumin , Li Nasi , Carter Kevin A. , Shao Shuai , Atilla-Gokcumen G. Ekin , Lovell Jonathan F.
Published: April 2023

Body mass of mice receiving different treatments with PoP liposomes. 5 mg/kg liposomal Dox or equivalent, laser treatment was initiated 15 min post administration at 200 mW/cm2 for 8.3 min (100 J/cm2). Mean{plus minus}s.d. for n=5.
Figure S5 from MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer
Authors: Oudin Madeleine J. , Barbier Lucie , Schäfer Claudia , Kosciuk Tatsiana , Miller Miles A. , Han Sangyoon , Jonas Oliver , Lauffenburger Douglas A. , Gertler Frank B.
Published: April 2023

MENA expression alters MT length
Figure S3 from Vessel-Targeted Chemophototherapy with Cationic Porphyrin-Phospholipid Liposomes
Authors: Luo Dandan , Geng Jumin , Li Nasi , Carter Kevin A. , Shao Shuai , Atilla-Gokcumen G. Ekin , Lovell Jonathan F.
Published: April 2023

Total energy required to reach 90% Dox release for the 20% DOTAP formulation.
Figure S1 from MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer
Authors: Oudin Madeleine J. , Barbier Lucie , Schäfer Claudia , Kosciuk Tatsiana , Miller Miles A. , Han Sangyoon , Jonas Oliver , Lauffenburger Douglas A. , Gertler Frank B.
Published: April 2023

MENA expression in breast cancer and paclitaxel resistance
Supplementary movie S1. B 20 μM TFP from Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R
Authors: Kang Seokmin , Hong Jinpyo , Lee Jung Moo , Moon Hyo Eun , Jeon Borami , Choi Jungil , Yoon Nal Ae , Paek Sun Ha , Roh Eun Joo , Lee C. Justin , Kang Sang Soo
Published: April 2023

20 μM TFP-treated group. The cell were recorded in 2 h after seeding on 6-well plate equipped with x10 objective lens. The video were recorded by Cell Observer (Carl Zeiss, Germany).
Supplementary movie S1. A CTL from Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R
Authors: Kang Seokmin , Hong Jinpyo , Lee Jung Moo , Moon Hyo Eun , Jeon Borami , Choi Jungil , Yoon Nal Ae , Paek Sun Ha , Roh Eun Joo , Lee C. Justin , Kang Sang Soo
Published: April 2023

0.9% saline-treated control group. The cell were recorded in 2 h after seeding on 6-well plate equipped with x10 objective lens.
Supplementary Table S1 from Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic HER4 Mutations in HNSCC
Authors: Nakamura Yu , Togashi Yosuke , Nakahara Hirokazu , Tomida Shuta , Banno Eri , Terashima Masato , Hayashi Hidetoshi , de Velasco Marco A. , Sakai Kazuko , Fujita Yoshihiko , Okegawa Takatsugu , Nutahara Kikuo , Hamada Suguru , Nishio Kazuto
Published: April 2023

50% Inhibitory concentrations (IC50) in esophageal or head-and-neck squamous cell carcinoma (ESCC or HNSCC) cell lines
Supplementary Figure S2 from Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic HER4 Mutations in HNSCC
Authors: Nakamura Yu , Togashi Yosuke , Nakahara Hirokazu , Tomida Shuta , Banno Eri , Terashima Masato , Hayashi Hidetoshi , de Velasco Marco A. , Sakai Kazuko , Fujita Yoshihiko , Okegawa Takatsugu , Nutahara Kikuo , Hamada Suguru , Nishio Kazuto
Published: April 2023

Influence of NRG1, a HER4 ligand, on the HRE4 G1109C mutation. A cellular growth assay using 1% FBS medium and western blotting using serum-free medium were performed. When the transfectant HEK293 cell lines were incubated with serum-free medium, the phosphorylation level of HER4 was also elevated in the HEK293/HER4 G1109C and HEK293/HER4 E317K cell lines, compared with that in the HEK293/HER4 WT cell line. NRG-1 (50 ng/mL) enhanced the cellular growth and phosphorylation level of HER4 in the HEK293/HER4 G1109C and HEK293/HER4 E317K cell lines to extents similar to those in the HEK293/HER4 WT cell line. β-actin was used as an internal control. Column, mean of independent triplicate experiments; error bars, SD; n.s., not significant; *P < 0.05.