bluuebunny/crossref_metadata_2025 huggingface dataset:
Ocimum basilicum extract modulates Tau aggregation and improves memory function in a neurodegenerative rat model
Authors: Shalan Mrwa , Alhasan Layla
Published: October 2023

The main objective of this study was evaluation of the neuroprotective potential effect of Ocimum basilicum on oxidative stress status in rat induced Alzheimer's disease. Fifty rats were divided into five groups (ten rats each). Rats were treated orally with AlCl3 to induced AD. Group 1 (control group). Group 2 (AD group): supplemented orally with AlCl3 (17mg/kg/day) for four weeks. Group 3 (OB/AD group) supplemented concomitantly with oral rivastigmine (3 mg/kg /day). Group 4 (OB/AD group) supplemented concomitantly with oral OB (250mg/kg/day) and Group 5 (OB/AD group) supplemented concomitantly with oral OB (500 mg/kg/day). The results showed that the plant leaves extract increased serum superoxide dismutase (SOD) with a significant decrease of a serum MDA and also the aggregation of tau protein expression was decreased . Histological changes were observed in brain tissues of AD rats. However, the high dosing of the plant leaves extract (500 mg/kg) was more powerful than the low treatment with low dose (250 mg/kg) by decreasing Tau protein expression. The results suggest that Ocimum basilicum can relieve symptoms and prevent the progression of AD severity by improving memory function. It can be concluded that OB leaves were alleviated the memory impairment and learning abilities due to antioxidants activity of flavonoids, tannins and terpenoids.
Effectiveness of a gluten-free diet on the autoantibody frequency of endocrine and neuron disorders in patients with celiac disease
Authors: Elia Zaid , Berwary Najat
Published: October 2023

Several possible associations between different types of autoimmune diseases have been reported, therefore this study aimed to investigate the relationship between celiac disease (CD) and some related autoimmune diseases by determining the effect of gluten on severity of these diseases. Two hundred blood samples were collected, 50 samples were withdrawn from healthy donors as a control group, 75 were collected from newly diagnosed (ND) CD patients, while the remaining blood samples (75) were obtained from the same patients after 4 months of gluten free diet (GFD) regime. Sera were separated to measure the level of anti-tissue transglutaminase IgA (tTG-IgA), anti-pituitary IgG, anti- thyroid peroxidase IgG (TPO- IgG), anti-islet IgG and anti-ganglioside IgG (IU/ml) by enzyme linked immunosorbent assay (ELISA). To analyze the results and compare between groups, GraphPad Prism was utilized. The results recorded high significant elevation (p>0.0001) in the concentrations of all autoantibodies of both ND and GFD groups compared with their concentrations in the control group. Furthermore, after 4 months of GFD, all autoantibodies concentrations revealed highly significant decreases (p>0.0001) as compared with ND. Regarding the correlation of all studied autoantibodies with anti tTG-IgA, only anti-ganglioside IgG levels were weakly correlated in pre-GFD treatment patients, meanwhile anti-ganglioside IgG and anti-pituitary IgG were also recorded weak correlations in post- GFD of CD patients. This study concluded that GFD helps to reduce the severity of endocrine and neuron autoimmune disorders in addition to CD, which have been proved by decreasing in the level of their diagnostic autoantibodies.
Association between masked hypertension and late-onset fetal growth restriction at advanced maternal age
Authors: Ozkan Nazli , Dirican Aylin , Kadioglu Nezaket , Yildiz Gorkem
Published: October 2023

Fetal growth restriction (FGR) is a major risk factor for complicated pregnancy including stillbirth. The all-pathophysiology results in uteroplacental insufficiency. Hypertension chronic or pregnancy-related complicates the all-prenatal periods. The relationship between fetal growth restriction and hypertension is well-known and this risk increases with maternal age. Late-onset FGR is diagnosed >32 weeks. Masked hypertension (MH) is a phenotype of hypertension when clinic blood pressure is in the normal range in the office but elevated outside the office. This study examined the risk of late-onset FGR and masked hypertension at advanced maternal age. Sixty pregnant women over 40 years old were included in the study who delivered at our hospital with late-onset fetal growth restriction diagnosis. After taking detailed anamnesis from all individuals included in the study, detailed physical examination, obstetric examination and ambulatory blood pressure monitoring (ABPM) were performed. Women with maternal chronic hypertension, pregestational or gestational diabetes mellitus, chronic kidney disease, rheumatoid disease history, tobacco use, cardiac arrhythmia, fetal genetic abnormality or placental abnormality were excluded from the study. The prevalence of masked hypertension was statistically significantly higher in the group with late intrauterine growth. (n:13, 43% vs n:5, 16.7% p=0.02). Office systolic BP (125.5±4.1 mmHg vs 118.5±5.7 mmHg p=0.016), 24-hour systolic BP measurement (125±9 mmHg vs 119.7±5.7 mmHg p=0.03), and ambulatory nocturnal diastolic BP measurement (66.7±10 mmHg vs. 61.±5.5 mmHg p=0.03) was higher in the group with late FGR. Hypertension can lead to complications in the perinatal period. There is a bad association between FGR and hypertension. Masked hypertension should be considered especially in advanced age pregnant individuals with FGR.
Evaluation of the stress distributions of the treatment options with 2 implants for 4 missing maxillary incisors with finite element analysis
Authors: Gumus Hilal
Published: October 2023

The aim of this study is to evaluate the stress distributions in the bone level, implant and prosthesis parts with three-dimensional (3D) finite element analysis (FEA) in treatment options obtained by using two implants in different positions and different diameters in the four missing maxillary incisors region. Four 3D FEA models were obtained simulating the human maxilla with anterior 4 missing teeth. It is an in vitro study evaluated only by performing FEA with a computer program. Model 1 (M1): 4.3mm diameter implant to 2 central incisors regions, Model 2 (M2): 4.3mm diameter implant to 2 lateral incisors regions, Model 3 (M3): 3.3mm diameter implant to 2 lateral incisors regions and Model 4 (M4): 4.3mm diameter implant to central incisor region, 3.3mm diameter to lateral incisor region. Titanium implants and titanium abutments were used. Four-unit monolithic zirconia cemented fixed partial prostheses were designed on them. An oblique force of 100N was applied to the cingulum of each tooth on the prosthesis at an angle of 45 degrees to the long axis. The data obtained by performing FEA on the stress values in the implants, prosthesis parts and bone were evaluated. Maximum and minimum principal stress in the bone tissue was observed most in model 3 and least in model 1. Von Mises values in the abutment, implant, screw and prosthesis were highest in model 3. According to the obtained stress values, it may be considered the best option to place a standard diameter implant where the central incisors are in the anterior region in order to reduce the stress on the bone. Treatment with a narrow-diameter implant with lateral incisors can be avoided.
Noise exposure in healthcare workers
Authors: Deniz Huseyin , Sarac Elif
Published: October 2023

The aim of this study is to evaluate the effect of noise in hospitals on healthcare workers, to develop recommendations for reducing noise in hospitals and to show why healthcare workers should be protected from noise exposure in hospitals. The study included a total of 80 healthcare workers from different units of the hospital who volunteered to participate. Two participants were excluded for sensorineural hearing loss and the results of 78 respondents were analyzed. Participants were evaluated using a questionnaire created by the researchers. Noise in different units of the hospital was measured during daytime working hours using the Sound Level Meter application with an iPhone 13® smartphone. Measurements yielded a mean noise level of 37.62 dBA (a minimum of 24.21 dBA to a maximum of 67.31 dBA). On occasions, noise levels in the hospital were as high as 74 dBA. Healthcare staff included in the study usually complained of moderate levels of noise and reported noise affected their performance. High levels of noise in hospitals negatively affect healthcare workers’ performance. Healthcare workers’ awareness about the impact of noise exposure in hospitals should be increased through in-service training programs. Improving noise levels in hospitals and implementing noise reduction interventions can help increase healthcare workers’ performance and eliminate the negative impacts of noise exposure to the inner ear.
Examination of attitudes towards healthy nutrition in athletes
Authors: l Serhat , Cebi Ali , Cebi Mehmet , Demir Mustafa
Published: October 2023

The aim of this study was to investigate the attitudes of athletes towards healthy nutrition. A total of 199 athletes. 85 males and 114 females. studying at Ondokuz Mayis University Yasar Dogu Faculty of Sport Sciences. participated in the study. In this study. Attitude Scale on Healthy Nutrition was used as a data collection tool. The data were analysed using SPSS 22 package programme. Kurtosis and Skewness values of the data were examined for normality determination. Since the sub-dimension of knowledge about nutrition in active sportsmen did not show normal distribution. Mann-Whitney U test was applied from non-parametric tests. As a result of the analyses made according to the gender. age. height and weight variables of the participants. there is no significant difference (p>0.05). In the comparison of athlete and sedentary variables according to active sports status. there is a significant difference in all sub-dimensions (p<0.05). As a result, it was observed that males who were active in sports had more knowledge about healthy eating than females and that athletes had higher attitudes towards healthy eating than sedentary individuals. It can be said that a regular and balanced diet will have a positive effect on the athlete's performance in training and competition and will help them to achieve success in competition.
A comparison of code blue calls in a tertiary pediatric hospital in the pre-pandemic and pandemic periods
Authors: Akdeniz Sevda , Kusderci Hatice , Adiguzel Senay
Published: October 2023

This study compares the code blue calls (CBCs) used in our hospital before and during the COVID-19 pandemic. CBCs made between 31.03.2018 and 31.03.2022 in the Samsun Maternity and Child Health Training and Research Hospital were examined retrospectively. The study period was subdivided into two sections, one from March 31, 2018, to March 30, 2020 (Group 1, the pre-pandemic period) and the other from March 31, 2020, to March 31, 2022 (Group 2, the pandemic period). Patients' demographic data, the reason for the CBC and where it was issued, the time elapsed before the team arrived on the scene, and the outcomes were then compared between the groups. Seventy-nine CBCs, 34 (43.1%) of which were ‘false,’ were included in the study. Forty-six calls were made in the pre-pandemic period, 26 (56.5%) of which were true calls, while 33 calls were made during the pandemic, of which 19 (57.6%) were true calls. Twenty-seven (60%) of the 45 true CBCs were for boys and 18 (40%) for girls. The children’s mean age was 73.06±66.85 months, and 57.7% of the CBCs were issued during the pre-pandemic period. No significant difference was observed between groups 1 and 2 in terms of code blue team arrival times (114.03±59.14 vs. 138.1±95.96 sec, respectively (P=.305). The total mortality rate at the end of 30 days was 13.3% (P=.679). No difference was observed in CBC results between the pre-pandemic and pandemic periods in this study. We think that some blue code parameters, such as false calls and blue code team arrival times, can be improved through effective training against potential future pandemics.
Pre-treatment pan-immune-inflammation value (PIV) and pile prognostic score in patients treated with immunotherapy
Authors: Olgun Polat , Diker Omer
Published: October 2023

Investigating predictive markers for inflammatory events in cancer, there was a trend observed in the diversity of prognostic scores obtained from blood counts. This study aimed to assess the pan-immune-inflammation value (PIV), encompassing lymphocyte, monocyte, neutrophil and platelet levels along with the PILE score (a composite profile obtained from PIV, Eastern Cooperative Oncology Group Performance Score (ECOG PS) and serum lactate dehydrogenase (LDH)) in patients with diverse tumour types undergoing treatment with immune checkpoint inhibitors (ICIs). A retrospective study was carried out on a cohort of 105 patients with assessed pre-treatment PIV and PILE scores. Only stage III–IV patients were recruited. PIV was determined using absolute values from peripheral blood cell counts (neutrophil x platelet xmonocyte/lymphocytes) integrated at the time of diagnosis. The PILE scoring system further integrated LDH levels (<245 vs. ≥245) and ECOG-PS (0-1 vs. ≥ 2) along with the incorporated PIV values. Elevated PIV levels were significantly associated with a high response rate (RR) compared to those with lower PIV levels (HR:2.63, 95% CI:1.06–6.54; p=0.037). In this study, a PILE score of 3 emerged as a potential surrogate marker for progression-free survival (PFS) (HR=3.393, 95% CI: [0.822–13.996]; p=0,091). Further, an ECOG PS ≥2 was related to an elevated risk of both progression (HR=1.862, 95% CI: [1.030–3.364]; p=0.040) and overall survival (OS) (HR=2.399, 95% CI: [1.286–4.474]; p=0.006), alongside a reduced RR (HR=3.352, 95% CI: [1.397–8.043]; p=0.007). The impact of monocyte levels on PFS was statistically significant (HR=2.291, 95% CI: [0.999–5.251]; p=0.050). The study demonstrated an association between PIV and PILE scores and RR, PFS and OS in ICI-treated patients.
Association between mean platellet volume levels and mortality outcomes in geriatric patients in intensive care
Authors: Sen Irem , Sonmez Feruza
Published: October 2023

To prospectively evaluate the relationship between Mean Platelet Volume (MPV) levels and short-term mortality outcomes in critically ill patients aged ≥85 years. We hypothesized that abnormal MPV levels could offer actionable insights for predicting mortality risk in this highly vulnerable group, thereby improving therapeutic decision-making processes in the ICU setting. This study included patients aged ≥85 years. The participants were categorized into two groups based on their MPV levels at admission: group 1 (MPV≤12.5, normal range) and group 2 (MPV>12.5, elevated).A comprehensive set of variables, including demographic information, clinical indices, biochemical parameters, and respiratory metrics, were recorded. In a cohort of 475 participants, patients were stratified into two distinct groups based on MPV values: group 1 (n=400, 84.2%) and group 2 (n=75, 15.8%). The mean age was 89 (SD=7.7) and 88 (SD=6.2) years for group 1 and group 2, respectively, with a statistically significant difference (p=0.035). Significant differences were found in key biochemical parameters such as urea (p=0.045) and sodium (p=0.005). The most profound disparity was observed in platelet counts, with a highly significant p-value <0.001. The clinical outcomes showed a substantial divergence in the 30-day mortality rates between the two MPV-based cohorts (p<0.001). Additionally, a higher incidence of sepsis was recorded in the Group 2 (p=0.024). MPV is a significant prognostic indicator for mortality, 30-day mortality, and sepsis incidence, advocating its inclusion in routine clinical assessments to optimize patient care. Routinely accessible platelet indices serve as robust indicators for assessing both morbidity and mortality in critically ill patients.
Effects of seasonal conditions on septorhinoplasty patients
Authors: Okyay Mehmet
Published: October 2023

Our study aims to investigate the seasonal effects on the breath and quality of life (QoL) of patients who underwent septorhinoplasty (SRP). A total of 52 patients who underwent SRP between 2018-2023 were included in the study. Two groups those who operated in the winter (winter group, n=26) and those who performed in the summer (summer group, n=26) were evaluated with the NOSE (Nasal Obstruction Symptom Evaluation) scale to reveal the QoL after surgery. Compared with the summer group, NOSE scores in the winter group showed a statistically significant difference (p<0.05). Septorhinoplasty is a surgical procedure expected to increase the QoL of patients regardless of the season and climate. The low mean NOSE score observed in the winter showed that the postoperative patient comfort was significantly higher compared who underwent surgery in the summer. Therefore, encouraging patients to undergo surgery intensively during the winter months in SRP will be positive for postoperative QoL. Future studies may reveal more illuminating results for increasing patient comfort by considering different surgical techniques, climates, and months.
Modified naples prognostic score as a potential predictor for coronary slow flow: a retrospective observational study
Authors: Oguz Mustafa , Dogan Selami , Babaoglu Mert , Yilmaz Irem , Kilic Sahhan , Erdem Almina , Torun Akin , Seker Mehmet , Uzun Mehmet , Orhan Ahmet
Published: October 2023

The Naples prognostic score (NPS) predicts patient survival in gastroesophageal cancer using parameters related to nutritional and inflammatory status. These parameters include risk factors for coronary endothelial dysfunction except for low total cholesterol. Therefore, we modified the score (mNPS) to include high cholesterol, a risk factor for coronary endothelial dysfunction. We aimed to evaluate the relationship between mNPS and the angiographic epicardial coronary slow flow phenomenon (CSFP). This retrospective study included 301 patients with coronary slow flow who underwent coronary angiography between 2018 and 2022. The mNPS parameters were calculated and the population was divided into three groups based on the calculated parameters. Angiographic findings were classified in the left anterior descending (LAD), circumflex (Cx), right coronary (RCA) arteries, and three coronary arteries together. Statistical analyses were performed to identify mNPS as predictors of a slow flow phenomenon. Participants were divided into mNPS Group 1 (n=63), mNPS Group 2 (n=201), and mNPS Group 3 (n=37). No significant differences were observed in age, gender, or medications among the mNPS groups. The RCA had a statistically significant association with mNPS groups for slow flow phenomenon (p=0.006). Considering all three coronary arteries, the association with mNPS groups was also significant (p=0.005). White blood cell and lymphocyte counts showed significant differences. Compared with group 1, group 3 had 4.11 times more coronary artery slow flow. Our study suggests that the mNPS, integrating nutritional and inflammatory parameters along with high cholesterol, holds promise as a potential predictor for the coronary slow flow phenomenon. This could impact risk stratification and clinical management in this patient group.
Dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats
Authors: Polat Seyhan , Ekici Ozlem , Coskun Ebru , Ozhan Onural , Yildiz Azibe , Vardi Nigar , Erdemli Zeynep , Tukoz Yusuf , Acet Ahmet , Parlakpinar Hakan
Published: October 2023

Ovarian torsion is a gynecological emergency characterized by ovarian ischemic damage. This study aimed to investigate the possible protective effects of dexpanthenol (DEX)-an antioxidant molecule-against ovarian ischemic damage in rats. The rats were simple randomly grouped into (1) Sham group (n=8); (2) Ischemia (I) group (n=8) (2 hours of I in ovaries); (3) DEX+I group (n=8) (500 mg/kg DEX administration 30 minutes before 2 hours of I.) The removed ovaries were examined histopathologically and biochemically. In the DEX+I group, necrosis-pycnosis severity was significantly reduced compared to the I group; but congestion-hemorrhage severity was similar. In the I group, malondialdehyde (MDA) and total oxidant status (TOS) levels were slightly increased, and glutathione (GSH) levels were significantly decreased compared to the Sham group. In the DEX+I group, MDA and TOS levels were slightly reduced and GSH levels were slightly increased compared to the I group. DEX prevents ischemic damage in rat ovaries via an antioxidant effect. Further research is needed to support our findings.
PET/CT, an important imaging modality in the management of sarcoma patients
Authors: Erdogan Esra , Uner Aytug , Gumusay Ozge , Akdemir Umit
Published: October 2023

Sarcomas are a heterogeneous group of malignant tumors of mesenchymal origin. 18 Fluorodeoxyglucose (FDG)-Positron Emission Tomography (PET)/Computed Tomography (CT) is a combined imaging modality that could provide an anatomic and functional assessment of many solid tumors. In this study, the association between primary tumor characteristics (grade, histologic type, stage, localization) and the FDG-PET/ CT data of the primary tumor at the diagnosis were evaluated. The study aimed to determine the diagnostic role of numerical metabolic values determined in PET/CT in predicting grade, prognosis, and other patient characteristics of sarcoma patients. Patients with soft tissue and bone sarcoma who applied to the oncology department of Gazi University Faculty of Medicine between 2000 and 2014 were evaluated retrospectively. All patients underwent PET imaging with FDG before initiation of neoadjuvant chemotherapy or resection. Sarcoma patients (27 soft tissue, 18 bone sarcoma) were evaluated retrospectively in this study. Tumor size was found to correlate with SUVmax. Histologic grade was found to be associated with tumor 18F-FDG, but this was not statistically significant because of the small patient number. The optimal cut-off SUVmax value in showing the difference between low and high grades was 5.5. Overall survival was shown to be shorter in patients with SUVmax ≥5.5. In this study, we aimed to show the relationship between histologic grade and tumor metabolic activity. PET-CT could give an idea about tumor histologic grade and predict survival. It has an important role in diagnosis and also in determining the prognosis.
Investigation of single strand DNA breaks in spontaneous abortion cases with known pesticide exposure
Authors: Akgol Jale , Pektas Mine
Published: October 2023

Pesticide exposure is an essential public health problem and endocrine-disrupting factor. Encounters during pregnancy may cause spontaneous abortions or congenital anomalies with embryotoxic or fetotoxic effects. DNA double-strand breaks occur upon exposure of DNA to radiation and chemicals or are caused by faulty DNA metabolic processes. This research examines the relationship of DNA single-strand amount with pesticides and their types. Single-stranded DNA (ssDNA) density was quantitatively determined by fluorometric method in the blood of Spontaneous Abortion with organochlorine and or organophosphate pesticide exposure and in the blood of two patient groups who had normal delivery without pesticide contact. The mutation was screened by next-generation sequencing in 4 women who experienced spontaneous abortion with a high pesticide amount and variety. 91 female patients aged 18-35 years were included in the study. The spontaneous abortion group was 56 (61.5%), and the normal delivery group was 35 (38%) women. The mean age was 28.18(±4.5). There was a significant correlation between Pentachlorophenol -52 (PCB52) and ssDNA level (p<0.05). There was no relationship between ssDNA ratios and groups (p>0.05). It was determined that ssDNA levels were higher among those with multiple abortions. The ssDNA level was higher in those who had an abortion before (p<0.05). We determined that dichloro di phenyl tri chloro ethane (DDT) and its congeners were significantly higher in the Whole Exome Sequence analysis of 2 of the four patients with the highest pesticide level. The DYNC2H1 gene NM_001377.3 c.7506G>A (p.Trp2502Ter) variation and the DYNC2H1 gene NM_001377.3 c.8458C>A (p.Pro2820Thr) variation associated with recurrent miscarriages were found to be heterozygous. Studies in this area need to be increased to determine the relationship of ssDNA elevation with pesticide exposure, its predictive value in abortion, and the value of environmental factors in repeated abortions whose etiology has not been clarified.
Evaluation of prescribing pattern of fixed-dose combinations in obstetrics and gynecology department of a tertiary care hospital of central India
Authors: Siddiqui Riyaz , Shende Tanaji , Mahajan Harshal
Published: October 2023

Background: Improved patient compliance and cost effectiveness are two benefits of fixed-dose combination drugs. Irrational fixed-dose combinations (FDCs) raise the most urgent issue since they put patients at needless risk for negative medication responses.

Aims and Objectives: The present study was done with objective of analyzing prescribing pattern of FDCs in department of fixed-dose combination in department of obstetrics and gynecology in a tertiary care hospital of central India.

Materials and Methods: This study, which was both prospective and observational, was conducted at the tertiary care hospital of central India. This study comprised the prescriptions of all patients who visited the obstetrics and gynecology Outpatient Department during the study period.

Results: In the present study, 1605 prescriptions were analyzed, comprising total 3016 drugs. Out of these 1262 were prescribed as FDCs and 1754 were prescribed as single drugs. On analyzing system-wise prescriptions, it was found that majority drugs were prescribed pertaining to gastrointestinal tract, that is, 1720 prescriptions, of which 722 (38.8%) were prescribed as FDCs. Four hundred and sixty-three drugs were prescribed related to hematological system, of which 97 (14.9%) were FDCs. Four hundred and thirty-three drugs were prescribed related to anti-infective class, comprising 196 (36.6%) FDCs. Among FDCs prescribed in gastrointestinal system, Vitamin D3 + Calcium carbonate was most commonly prescribed, accounting for 644 (51%) prescriptions. Clotrimazole + Clindamycin was most commonly prescribed FDC in anti-infective system comprising 118 (9.3%) patients. Ferrous ascorbate + folic acid was most commonly prescribed hematological FDC, accounting for 49 (3.8%) patients. Dextromethorphan + phenylephrine + Chlorpheniramine was most commonly prescribed FDC in respiratory segment accounting for 39 (2.9%) patients.

Conclusion: The present study highlights a considerable number of drugs prescribed as FDCs. FDCs reduce pill burden and also help to improve patient compliance. However, rationality of FDCs should be thought before prescribing it to patients.
Causes and consequences of the round goby invasion in the Baltic Sea and beyond
Authors: Wallin Kihlberg Isa
Published: October 2023

Species invasions have increased rapidly over time and pose negative effects on ecosystems and societies worldwide. The round goby, one of the most widespread invasive fishes in the northern hemisphere, established in the Baltic Sea in 1990. My results show that the round goby, in contrast to most native species in the coastal fish community, exhibits territorial behaviour and parental care, which may have given it a competitive advantage and facilitated its establishment in the Baltic Sea. I found the major diet components of the round goby to be macroinvertebrates, but DNA metabarcoding revealed feeding also on several fish species, likely in their early life stages. Further, the round goby constituted prey for cod, perch and pike. When round goby was abundant in the environment, the reliance on fish prey increased for both round goby and its predators. As a potential consequence of round goby expansion to freshwater, I further studied round goby interactions with spawning salmon. Presence of round goby delayed salmon spawning, and male and female salmon resided closer together in the presence of higher densities of round goby compared to lower densities, which could be interpreted as a protective behaviour. In order to minimise the negative effects of the round goby in and around the Baltic Sea, I recommend management measures to reduce its abundances and prevent further spread, for example by strengthening native coastal predatory fish populations, developing a round goby fishery and developing a system for early detection and eradication of the round goby in rivers and streams.
Endovascular Treatment of Symptomatic Basilar Artery Stenosis
Authors: Kim Jae Ho , Cho Kwang-Chun , Kim Taemin , Ha Sang Woo , Suh Sang Hyun
Published: October 2023

Purpose: While symptomatic basilar artery (BA) stenosis is associated with a higher risk of recurrent stroke or death, there is no consensus on the management of these patients who are refractory to antiplatelet therapy. This study retrospectively assesses the outcomes of endovascular treatment (EVT) for symptomatic BA stenosis.Materials and Methods: We conducted a retrospective review of patients with symptomatic BA stenosis who underwent EVT, including angioplasty or stenting, from 2006 to 2018. A total of 15 patients, who experienced transient ischemic attacks or strokes despite dual antiplatelet therapy, were included. EVT was performed under local anesthesia after pretreatment with antiplatelet medications. Angiographic follow-up was performed at 12 and 24 months post-EVT. Clinical outcomes were evaluated using the modified Rankin Scale (mRS).Results: EVT was successfully completed in all patients. Peri/post-procedural complications occurred in 33% of cases, including in-stent thrombosis, intracranial hemorrhage, and pontine infarction. At long-term follow-up (mean 98.5±80.5 months), 73.3% of patients achieved a favorable functional outcome (mRS≤2) without disability or mortality. Patients with unfavorable outcomes had previous infarcts, with 2 experiencing new pontine infarctions after stenting.Conclusion: This study suggests that EVT, including angioplasty and stenting, may offer promise as a treatment option for symptomatic BA stenosis refractory to medical therapy. However, the procedure carries a notable risk of complications, especially in patients with severe stenosis and previous infarcts. Careful patient selection, based on clinical and radiological criteria, is crucial.
Analysis of Network Security in IoT-based Cloud Computing Using Machine Learning
Authors: Humaira Naeem
Published: October 2023

Network security in IoT-based cloud computing can benefit greatly from the application of machine learning techniques. IoT devices introduce unique security challenges with their large-scale deployments and diverse nature. Machine learning can help address these challenges by analyzing IoT network traffic, detecting anomalies, identifying potential threats, and enhancing overall network security. The security of cloud networks is validated using binary classification to detect attacks. Random forest classifiers achieved an accuracy of 96%, while K nearest classifier had an accuracy of 93% and a precision value of 0.96. The proposed model ensures security of big data against intrusion attacks on the network. Although machine learning techniques can be powerful for protecting cloud computing networks, challenges still need to be addressed before widespread adoption. Understanding the potential and limitations of machine learning approaches to network security canhelp researchers and practitioners develop more effective strategies for safeguarding their systems in an increasingly interconnected world. Network security of big data in cloud computing can be enhanced by applying machine learning techniques. Machine learning algorithms can analyze large amounts of data to detect patterns, anomalies, and potential security threats. Here are several ways machine learning can be utilized to improve network security in the context of big data and cloud computing.
PESQUISA E DOCÊNCIA: A EDUCAÇÃO BÁSICA RURAL NO MUNICÍPIO DE TAQUARANA/AL
Authors: Costa José Barbosa , De Melo Pedro Antonio Gomes
Published: October 2023

Na contemporaneidade, surge o reconhecimento de que as pessoas locadas na zona rural, têm direito a uma educação de qualidade, diferente daquelas que vivem na zona urbana e periferias das cidades. Neste contexto, ao pensarmos sobre a relação da pesquisa com a prática docente no âmbito da Educação do Campo, identificamos alguns pontos divergentes entre as ideias propostas na literatura especializada, sobretudo com relação à prática de pesquisa pelo professor e a realidade por ele vivenciada em seu cotidiano escolar. Sob esse viés, este artigo tem como objetivo pensar a formação do professor-pesquisador que atua na Educação Básica Rural no município de Taquarana/AL, apresentando uma reflexão teórico-pedagógica sobre as atividades deste profissional, tendo a escola como foco de pesquisa. O itinerário teórico-metodológico que embasou nosso estudo, sinaliza concepções profícuas sobre o elo pesquisa/docência na visão de autores como: Anderson (1998); André (2013), Bagno (1998); Demo (1992, 2011); Fazenda (2000); Freire (2000); (GOLDENBERG, 2004) ;(HAGE, 2010); Imbernon (2009); (LOUZADA 2018); Ludke (2002), (MARCELO 2009); Morosini (2000); Pinsky (2005), Severino (2007); Zabalza (2004), entre outros. Como conclusão dessa reflexão, destacamos a relevância dessa problematização acerca das relações que se imbricam entre o professor do ensino básico e a investigação científica dentro de uma realidade contemporânea à medida em que propomos o ato de pesquisar aliado à teoria e à prática docente do professor da escola básica. Os resultados apontaram para que Taquarana apresenta grandes desafios para a educação básica rural, relacionados ao acesso à infraestrutura, equipamentos, profissionais qualificados, abordagens pedagógicas inclusivas, programas de apoio ao ensino e assim por diante. Essas questões estão inseridas em um contexto de desigualdade regional, desenvolvimento desigual entre as populações da zona urbana e rural, apresentando uma simetria muito lenta nos índices de aprovação nos exames de avaliação obrigatórios e, o interesse dos alunos no processo educativo, especialmente na comunidade rural, torna-se preocupante uma elevada simetria no campo de aprendizados de novos conhecimentos científicos.
PERCEPÇÃO DOS PERITOS CONTADORES DO ESTADO DE MATO GROSSO EM RELAÇÃO AS MUDANÇAS OCORRIDAS NO NOVO CÓDIGO DE PROCESSO CIVIL
Authors: Kawakami Aline , De Lima José Ricarte , Pereira Vanusa Batista , Da Costa Enézio Mariano , Durigon Almir Rodrigues , Da Silva Juliana Vitória Vieira Mattiello
Published: October 2023

O Novo Código de Processo Civil (NCPC) brasileiro que entrou em vigor em 2016, trouxe várias alterações, entre as quais, mudanças relacionadas à atuação dos peritos. Nesse sentido, o presente estudo buscou verificar a percepção dos peritos contadores em relação as mudanças ocorridas no NCPC. Para tanto, elaborou-se um questionário com perguntas abertas e fechadas e encaminhado aos respondentes por meio de e-mails pessoais, obtidos no site do Cadastro Nacional dos Peritos Contadores (CNPC), utilizando-se da plataforma Google Docs. O estudo desenvolveu-se com profissionais peritos que atuam no Estado de Mato Grosso. As evidências apontadas pelo o estudo são de que 65% dos respondentes são do sexo masculino e que a faixa etária da maioria dos peritos respondentes está entre 41 a 60 anos. Os resultados revelaram ainda que, 80% dos respondentes são mais solicitados para atuarem em recuperação judicial. Em relação a percepção dos peritos contadores sobre as mudanças ocorridas no NCPC, os resultados mostraram que segundo os respondentes o NCPC ampliou o papel do perito contador, aumentando a responsabilidade do perito, mas ressaltando a cooperação que deve existir entre as partes visando solucionar os litígios de forma consensual.
DIAGNÓSTICO DO CENÁRIO DA SÍFILIS NO BRASIL: UMA ANÁLISE DOCUMENTAL E DE ESTUDOS CIENTÍFICOS PARA FUNDAMENTAR A CONSTRUÇÃO DE UM DESENHO DIDÁTICO E UM CURSO ONLINE MASSIVO NO AMBIENTE VIRTUAL DE APRENDIZAGEM DO SISTEMA ÚNICO DE SAÚDE (AVASUS)
Authors: De Moura Micheline Veras , Trindade Sara Marisa do Carmo Dias , Moreira José António Marques , Dias Aline de Pinho
Published: October 2023

A sífilis é uma Infecção Sexualmente Transmissível curável e exclusiva do ser humano, causada pela bactéria Treponema pallidum. O objetivo deste estudo foi identificar a partir de análise documental e de artigos científicos, o cenário da sífilis no Brasil para construção de um desenho didático e um curso online autoinstrucional e massivo, fundamento na Saúde Baseada em Evidências para o enfrentamento da sífilis pelos profissionais de saúde. Trata-se de um estudo de Revisão da literatura e documental nas bases de dados como a PubMed, Biblioteca Virtual em Saúde (BVS), Scientifc Eletronic Library Online (Scielo) e na revista Elsevier. Os documentos analisados foram nas bases públicas do Ministério da Saúde do Brasil e do Tribunal de Contas da União. Na busca e seleção dos artigos foram selecionados 10 artigos científicos, os Boletins Epidemiológicos da Sifilis (2015 a 2020), o Protocolo Clínico e Diretrizes Terapêuticas (PCDT) e o Ácordão 2017/2019.  Considerando a necessidade de diminuir a incidência da sífilis, mostra-se significativo que os profissionais e os gestores da saúde, tenham acesso às informações de forma fidedigna e efetivas para que possam intervir com Políticas de Saúde e intervenções de acordo com a magnitude do problema. A sífilis é uma patologia de alta relevância na história da saúde, porém a redução e erradicação persistem como um problema grave para o Sistema de Saúde do Brasil, o que contraria seu tratamento, teste e diagnóstico, pois são de baixo custo. Contudo, desde 2018 o Projeto “Sifilis Não!” tem sido como uma ferramenta de indução de política pública do Ministério da Saúde em intensa comunicação com a Política Nacional de Educação Permanente em Saúde e tem contribuído de maneira significativa, propiciando a redução dos casos de sífilis em todo o país. Porém, entendemos que ainda há muito a ser feito no Brasil, pois precisamos reduzir a taxa de sífilis congênita para os níveis aceitáveis, como preconizado pela OMS.
CIÊNCIAS NOS ANOS FINAIS DO ENSINO FUNDAMENTAL: ENSINO DE QUÍMICA POR MEIO DE ATIVIDADES EXPERIMENTAIS ACESSÍVEIS
Authors: Ferreira Davi Souza , Sousa Everaldo Nicomedio Santo , Dias Diogo Brito , Ferreira Joady Sousa , Castilho Quesia Guedes da Silva , Santos Alan Jhones da Silva , Sá-Silva Jackson Ronie , Dias Vera Lúcia Neves
Published: October 2023

Os conteúdos geralmente dispostos em livros utilizados na disciplina Ciências no nono ano do ensino fundamental são os de Química e Física, e tais objetos do conhecimento são resumidos, dificultando assim a aprendizagem dos alunos. Diante deste empasse didático-pedagógico no ensino de Ciências, houve a necessidade de se refletir sobre a referida temática. Para tanto se fez necessário a escolha de uma escola da rede pública de ensino para realização da presente pesquisa que teve como objetivo confeccionar kits didáticos de baixo custo para a utilização em aulas experimentais no ensino de Ciências do nono ano, com a intenção de fazer com que os alunos compreendessem melhor os conceitos químicos e desmistificarem a ideia de que os conteúdos de química são muito difíceis. Elaborou-se kits didáticos para a apresentação das temáticas “modelos atômicos” e “tabela periódica”. Mediante a situação da pandemia houve a necessidade de aplicar um questionário pelo Google Forms, que muito contribuiu para conhecer o perfil dos alunos de uma escola da rede pública de ensino de São Luís, Maranhão, Brasil. A receptividade para as aulas experimentais foi algo que apareceu com muita clareza. Desenvolveu-se aulas práticas investigativas e questionadoras, pois, a utilização dos kits didáticos contribui de maneira significativa para a aprendizagem dos alunos e proporcionou a desmistificação da ideia de que o conhecimento químico é de difícil compreensão.
Problematika Pendidikan Agama Islam dan Upaya Merespon Perkembangan Abad 21
Authors: Sa’datul Marwah Rosedah
Published: October 2023

Pada hakikatnya tujuan pembelajaran adalah perubahan sikap siswa, baik perubahan perilaku pada bidang kognitif, afektif, dan psikomotorik. Namun pada abad ke 21 ditandai munculnya problem seperti perubahan sosial, teknologi, dan budaya yang signifikan, yang mempengaruhi cara orang hidup, berinteraksi, dan pengetahuan. Dalam merespon problematika tersebut, pemerintah mengeluarkan kebijakan salah satunya kurikulum merdeka belajar. Kurikulum tersebut memiliki tujuan pembelajaran yaitu memberikan keleluasaan kepada pendidik untuk menciptakan pembelajaran berkualitas yang sesuai dengan kebutuhan dan lingkungan belajar peserta didik. Selain itu membangun pribadi peserta didik yang memiliki prilaku baik, menekankan pembelajaran yang kontekstual dan berbasis kehidupan nyata. Dalam hal ini, masalah etika dan moral dapat dibahas lebih mendalam dan relevan dengan kehidupan sehari-harinya. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis problematika yang dihadapi dalam pendidikan agama Islam dalam merespon perkembangan abad ke-21. Metode penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan studi literatur dan analisis data sekunder. Dalam hasil penelitian ini menyimpulkan adanya problematika yang harus dihadapi pada abad 21 ini yakni kemorosotan moral menjadi tantangan untuk menyusun kurikulum yang relevan, pemanfaataan teknologi terhadap PAI yang masih kurang, dan  pandangan bahwa agama adalah formalitas yang mana berdampak pada  pembelajaran agama Islam yang dianggap mudah tanpa perlu mendalami keilmuannya berdampak kurangnya sikap toleran pada peserta didik. Implikasi penelitian ini diharapkan dapat memberikan upaya kontribusi dalam pengembangan kurikulum, penggunaan teknologi dalam pendidikan agama Islam, serta promosi pemahaman inklusif dan toleran dalam konteks yang semakin global dan multikultural
Authors: Azzahra Bunga Surya , Movitaria Mega Adyna
Published: October 2023

Penelitian ini dilatarbelakangi adanya remaja yang mengalami gangguan depresi dengan dipicu oleh kasus Toxic Relationship. Tujuan penelitian ini adalah untuk mengetahui bagaimana keterkaitan antara kasus Toxic Relationship dengan gangguan depresi pada remaja. Penelitian ini menggunakan metode kualitatif. Data dikumpulkan dengan cara studi kasus, observasi dan kuesioner. Lokasi penelitian tepatnya berada di SMA Negeri 1 Pariaman. Dengan jumlah responden sebanyak 27 orang remaja berusia 16-17 tahun. Menggunakan teknik analisis data yaitu reduksi, display, dan verifikasi data. Hasil penelitian ini menyatakan bahwa adanya keterkaitan antara Toxic Relationship yang dapat menyebabkan gangguan depresi bagi remaja yang mengalaminya.
Authors: Ariesta Laura , Movitaria Mega Adyna
Published: October 2023

Penelitian ini dilakukan berdasarkan observasi lapangan pada siswa kelas III Sekolah Dasar. Penelitian ini bertujuan untuk meningkatkan pemahaman siswa terhadap pembelajaran IPA kelas III SD melalui metode pembelajaran media video animasi. Metode penelitian yang digunakan adalah metode kualitatif dengan melakukan pengamatan di lapangan  dengan membentuk dua kelompok berbeda, menampilkan dua metode pembelajaran yang berbeda. Metode pertama dilakukan dengan cara menyajikan video animasi yang berkaitan dengan materi yang akan disampaikan dan metode kedua dilakukan dengan cara yang biasa dilakukan oleh guru pada saat mengajar, dan selanjutnya dilakukan observasi dengan sesi wawancara dan dokumentasi. Hasil penelitian yang didapatkan adalah banyak anak yang tertarik dengan metode animasi video, mereka lebih fokus melihat layar dan aktif merespon ketika ada beberapa pertanyaan yang disajikan dalam animasi tersebut. Sedangkan penyampaian materi yang dilakukan oleh guru mereka lebih cenderung bosan, diam, dan tidak menanggapi pertanyaan yang diajukan guru. Dengan demikian dapat disimpulkan bahwa anak-anak lebih tertarik dengan metode pembelajaran video animasi dibandingkan dengan metode yang sering diajarkan oleh guru di sekolah
ONLINE LEARNING IN UNDERGRADUATE ACCOINTING EDUCATION DURING THE COVID-19 PANDEMIC
Authors: NG KIAN HONG , LEE TECK HEANG , TEOH MELISSA TENG TENK
Published: October 2023

When the COVID-19 outbreak hit, many educational institutions in Malaysia faced serious challenges. Using a qualitative approach, this study conducted face-to-face interviews with five accounting students and five accounting lecturers to gain insight into various issues of online learning in accounting education during this period. The study found that the flexibility of online learning benefits both students and lecturers, and it also provides them with the opportunity to improve their computing skills to live up to the demands of this period.The study revealed that the accessibility of video recordings and supplemental study resources are very beneficial in improving students' comprehension and performance in challenging courses like accounting. The use of teaching platforms such as Moodles or HLMS enable lecturers to manage assignments, respond to inquiries, and monitor students during tests and examinations. This improved monitoring capacity is a key benefit of online learning, allowing for more customised help and feedback for students. However, this mode of learning may not be suitable for students who lack self-discipline or seek attention and connection with lecturers and fellow students. Blended learning is recommended in the future to improve the quality of online learning. The technical support team can also help improve the smoothness of the online courses.
The Suitability of the Components of the Daily Assessment Book for Junior High School IPA Teachers (Biology) in Bekasi
Authors: Ratnapuri Adisti , Adinugraha Fajar
Published: October 2023

The Teacher's Daily Assessment Book is a form of teacher management. In fact, not all teachers are able to complete it. Therefore, the purpose of this study was to determine the format of the teacher's daily assessment book and to describe the suitability of the components of the daily assessment book in junior high school science teachers (biology). The research method used was field research with observation and interview techniques. The informants in the study were 10 junior high school science teachers (Biology) in Kecamatan Rawalumbu, Bekasi. All the respondents (100%) have document completeness in books 1 and 4. Unfortunately, not all the respondents have document completeness in books 2 and 3. Looking at the document completeness in book 2, only 50% of the respondents have document completeness. In Book 3, none of the respondents had 100% document completeness. The range of document completeness was from 69.23% to 84.62%. Finally, not all teachers have 100% complete documents in the workbook. This may be due to the administrative burden. This research is expected to provide insight into the need to balance the quality of teaching and the administrative burden on teachers.