bluuebunny/crossref_metadata_2025 huggingface dataset:
Designing Alternative Form-Autocompletion Tools to Enhance Privacy Decision-making and Prevent Unintended Disclosure
Authors: Knijnenburg Bart P. , Bulgurcu Burcu
Published: July 2023

Modern Web browsers provide users with tools to reduce the burden of filling out forms. Despite the widespread adoption of these tools, little is known about how they affect users’ privacy decision-making. This research compares traditional form autocompletion tools with two alternative tools designed for elaboration for this study (“add” and “remove” tools). The results show that the use of traditional form autocompletion tools significantly diminishes users’ deliberate privacy decision-making, while the proposed tools can mitigate these adverse effects, such that users (1) disclose significantly less information and (2) are more likely to assess the alignment between the type of the data requested and the goal of the entity requesting that data (i.e.,
context specificity
). While both proposed tools help users become more deliberate in their disclosure behavior, they prefer the “add” tool over the “remove” tool. Our results show that tools designed for elaboration can nudge users toward protecting their privacy.
Recent Progress in Leptonic and Semileptonic Decays of Charmed Hadrons
Authors: Ke Bai-Cian , Koponen Jonna , Li Hai-Bo , Zheng Yangheng
Published: July 2023

We present a comprehensive review of purely leptonic and semileptonic decays of D0(+), [Formula: see text], and charmed baryons (including [Formula: see text], Ξ c, and Ω c). The precise studies of these decays help deepen our understanding and knowledge of quantum chromodynamics via measuring decay constants and form factors, and test the Standard Model through examining the unitarity of the Cabibbo–Kobayashi–Maskawa matrix and lepton flavor universality. We give an overview of the theoretical and experimental tools before discussing the recent progress. The data sets collected by the Beijing Spectrometer III (BESIII) near the production thresholds of [Formula: see text], [Formula: see text], and [Formula: see text] offer important opportunities for studies of charm physics.
Do Different Estimation Methods Lead to Implausible Differences in the Size of Nonobserved or Shadow Economies? A Preliminary Answer
Authors: Schneider Friedrich
Published: July 2023

This review evaluates three micro and three macro estimation approaches to determine whether unrealistic differences exist in estimating the size of nonobserved/shadow economies. While some macro-MIMIC estimates are higher than estimates using the statistical discrepancy approach, when adjusting for double-counting, MIMIC approaches provide similar results. Macro approaches usually cover not only typical shadow economy activities, but also voluntary work, do-it-yourself activities, and classical crime activities; by nature, macro approaches will lead to higher and more accurate estimates than micro approaches. However, if certain adjustments are made, the estimated size of the shadow economy using the MIMIC approach comes close to the size of the shadow economy indicated by micro survey approaches. Hence, claims that macro approaches are unrealistically high and rely on unrealistic assumptions must be reconsidered.
Panaxynol alleviates colorectal cancer in a murine model via suppressing macrophages and inflammation
Authors: McDonald Sierra J. , Bullard Brooke M. , VanderVeen Brandon N. , Cardaci Thomas D. , Huss Alexander R. , Fan Daping , Hofseth Lorne J. , Murphy E. Angela
Published: July 2023

We report that panaxynol (PA) reduces colorectal cancer (CRC) by improving the colonic and tumor environment. Specifically, we demonstrate that PA improves crypt morphology, upregulates crucial tight junction and mucin genes, and promotes the abundance of mucin-producing goblet cells. Furthermore, PA reduces macrophages and associated inflammation, important drivers of CRC, in the colonic environment. This present study provides novel insights into the potential of PA as a therapeutic agent to ameliorate CRC tumorigenesis.
Di-(2-Ethylhexyl) Phthalate (DEHP) in House Dust in Canadian Homes: Behaviors and Associations with Housing Characteristics and Consumer Products
Authors: Zhang Luyao , Navaranjan Garthika , Takaro Tim K. , Bernstein Sarah , Jantunen Liisa , Lou Wendy , Mandhane Piush J. , Moraes Theo J. , Scott James A. , Simons Elinor , Turvey Stuart E. , Subbarao Padmaja , Brook Jeffrey R.
Published: July 2023

Background. Di-(2-ethylhexyl) phthalate (DEHP), which is ubiquitous in indoor environments, was the predominant phthalate measured in house dust in the Canadian CHILD Cohort and was found to be associated with a large increased risk of childhood asthma. Objective. To inform interventions by identifying sources of DEHP in dust and assessing behaviors related to DEHP concentrations in house dust. Methods. DEHP levels were measured in 726 dust samples collected at ~3 months of age in CHILD as well as in ~50 homes at two time points (June and November) in the CHILD pilot study. DEHP metabolites were measured in urine for a subset of the ~3-month-old infants. Housing characteristics were assessed at the time of dust and urine collection. Numerous factors from these surveys were investigated as potential sources of DEHP using univariate analyses and multivariable regressions. Correlations between DEHP in dust and urinary metabolites and between repeat dust samples were examined to study the relationship between dust measurement and DEHP exposure. Results. Overall, DEHP dust concentrations were higher for lower-income families. Homes with vinyl flooring in the kitchen and bathroom showed higher levels of DEHP than those without vinyl flooring. The quantity of vinyl furniture and the presence of mold were associated with higher DEHP concentrations, while the use of mattress covers reduced concentration. No other significant associations were found. DEHP concentrations in dust were consistent over 6 months, although the correlation between dust and DEHP metabolites in urine was low. Conclusion. DEHP in house dust persisted over multiple months, contributed to infant internal exposure, and was associated with specific housing characteristics. These findings may inform the public on their choice of building materials and products, as well as future policies, aimed at reducing the health risk associated with exposures in the indoor environment especially for children.
Molecular Characteristics, Sources, and Health Risk Assessment of Gaseous Carbonyl Compounds in Residential Indoor and Outdoor Environments in a Megacity of Northwest China
Authors: Li Lu , Dai Wenting , Shen Minxia , Niu Xinyi , Hu Tafeng , Duan Jing , Cao Junji , Shen Zhenxing , Ho Kin Fai , Li Jianjun
Published: July 2023

Carbonyl compounds (CCs) in indoor air pose a significant threat to residents’ health and have garnered considerable attention in recent years. However, most studies have focused on low-molecular-weight carbonyl compounds (LMW-CCs) and have underestimated the impact of high-molecular-weight ones (HMW-CCs), causing a failure to comprehensively understand their effects on health. In this study, we analyzed twenty carbonyls in the indoor and outdoor air at typical residential communities in a megacity in Northwest China by using high-performance liquid chromatography (HPLC) coupled with a photodiode array detector (DAD). The total concentration of indoor carbonyls was 1.4-3.4 times that of outdoor carbonyls. In addition, the concentration of indoor carbonyls was much higher during the heating season than that during the nonheating season. Conversely, the concentration of outdoor carbonyls was higher during the nonheating season than that during the heating season. The principal component analysis (PCA) revealed that indoor carbonyl pollution was primarily influenced by building materials, cooking fume, and wooden furniture. Formaldehyde exposure in indoor environments posed a greater health risk to children than acetaldehyde exposure. HMW-CCs were the primary contributors to indoor odor pollution, which was considered a significant cause of sick building syndrome (SBS). Our findings underscore the crucial role of HMW-CCs in indoor environments in exerting adverse impacts on health.
Supplementary Tables 1-3 from De Novo and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
Authors: Chakraborty Subhamoy , Coleman Charles , Manoj Parvathy , Demircioglu Deniz , Shah Nisargbhai , de Stanchina Elisa , Rudin Charles M. , Hasson Dan , Sen Triparna
Published: July 2023

Supplementary Tables 1-3
Figure S3 from De Novo and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
Authors: Chakraborty Subhamoy , Coleman Charles , Manoj Parvathy , Demircioglu Deniz , Shah Nisargbhai , de Stanchina Elisa , Rudin Charles M. , Hasson Dan , Sen Triparna
Published: July 2023

Figure S3: Lurbinectedin treatment induces regulators of the DNA damage response pathway.
Figure S1 from De Novo and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
Authors: Chakraborty Subhamoy , Coleman Charles , Manoj Parvathy , Demircioglu Deniz , Shah Nisargbhai , de Stanchina Elisa , Rudin Charles M. , Hasson Dan , Sen Triparna
Published: July 2023

Figure S1. Lurbinectedin decreases cell viability in a time and dose-dependent manner.
Supplementary Table S1 from CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression
Authors: Kohlmeyer Jordan L. , Lingo Joshua J. , Kaemmer Courtney A. , Scherer Amanda , Warrier Akshaya , Voigt Ellen , Raygoza Garay Juan A. , McGivney Gavin R. , Brockman Qierra R. , Tang Amy , Calizo Ana , Pollard Kai , Zhang Xiaochun , Hirbe Angela C. , Pratilas Christine A. , Leidinger Mariah , Breheny Patrick , Chimenti Michael S. , Sieren Jessica C. , Monga Varun , Tanas Munir R. , Meyerholz David K. , Darbro Benjamin W. , Dodd Rebecca D. , Quelle Dawn E.
Published: July 2023

Supplementary Table S1. Antibody sources and conditions for western blotting, IF, and IHC
Supplementary Figure S7 from CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression
Authors: Kohlmeyer Jordan L. , Lingo Joshua J. , Kaemmer Courtney A. , Scherer Amanda , Warrier Akshaya , Voigt Ellen , Raygoza Garay Juan A. , McGivney Gavin R. , Brockman Qierra R. , Tang Amy , Calizo Ana , Pollard Kai , Zhang Xiaochun , Hirbe Angela C. , Pratilas Christine A. , Leidinger Mariah , Breheny Patrick , Chimenti Michael S. , Sieren Jessica C. , Monga Varun , Tanas Munir R. , Meyerholz David K. , Darbro Benjamin W. , Dodd Rebecca D. , Quelle Dawn E.
Published: July 2023

Supplementary Figure S7. Analyses of p-RB1, Ki67, and PD-L1 in combination therapy-sensitive and - resistant MPNSTs and PD-L1 in NF1 patient tumors.
Supplementary Figure S2 from CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression
Authors: Kohlmeyer Jordan L. , Lingo Joshua J. , Kaemmer Courtney A. , Scherer Amanda , Warrier Akshaya , Voigt Ellen , Raygoza Garay Juan A. , McGivney Gavin R. , Brockman Qierra R. , Tang Amy , Calizo Ana , Pollard Kai , Zhang Xiaochun , Hirbe Angela C. , Pratilas Christine A. , Leidinger Mariah , Breheny Patrick , Chimenti Michael S. , Sieren Jessica C. , Monga Varun , Tanas Munir R. , Meyerholz David K. , Darbro Benjamin W. , Dodd Rebecca D. , Quelle Dawn E.
Published: July 2023

Supplementary Figure S2. Dual CDK4/6-MEK inhibition synergistically suppresses the growth of some, but not all, MPNST PDXs in immune deficient mice
Data from De Novo and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
Authors: Chakraborty Subhamoy , Coleman Charles , Manoj Parvathy , Demircioglu Deniz , Shah Nisargbhai , de Stanchina Elisa , Rudin Charles M. , Hasson Dan , Sen Triparna
Published: July 2023

AbstractPurpose:
Small-cell lung cancer (SCLC) is a high-grade neuroendocrine tumor with dismal prognosis and limited treatment options. Lurbinectedin, conditionally approved as a second-line treatment for metastatic SCLC, drives clinical responses in about 35% of patients, and the overall survival (OS) of those who benefit from it remains very low (∼9.3 months). This finding highlights the need to develop improved mechanistic insight and predictive biomarkers of response.
Experimental Design:
We used human and patient-derived xenograft (PDX)-derived SCLC cell lines to evaluate the effect of lurbinectedin in vitro. We also demonstrate the antitumor effect of lurbinectedin in multiple de novo and transformed SCLC PDX models. Changes in gene and protein expression pre- and post-lurbinectedin treatment was assessed by RNA sequencing and Western blot analysis.
Results:
Lurbinectedin markedly reduced cell viability in the majority of SCLC models with the best response on POU2F3-driven SCLC cells. We further demonstrate that lurbinectedin, either as a single agent or in combination with osimertinib, causes an appreciable antitumor response in multiple models of EGFR-mutant lung adenocarcinoma with histologic transformation to SCLC. Transcriptomic analysis identified induction of apoptosis, repression of epithelial–mesenchymal transition, modulation of PI3K/AKT, NOTCH signaling associated with lurbinectedin response in de novo, and transformed SCLC models.
Conclusion:
Our study provides a mechanistic insight into lurbinectedin response in SCLC and the first demonstration that lurbinectedin is a potential therapeutic target after SCLC transformation.
Data from Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Authors: Derry Jonathan M.J. , Burns Connor , Frazier Jason P. , Beirne Emily , Grenley Marc , DuFort Christopher C. , Killingbeck Emily , Leon Michael , Williams Claire , Gregory Mark , Houlton Jeffrey , Clayburgh Daniel , Swiecicki Paul , Huszar Dennis , Berger Allison , Klinghoffer Richard A.
Published: July 2023

Abstract
Purpose: Cancer drug development is currently limited by a paradigm of preclinical evaluation that does not adequately recapitulate the complexity of the intact human tumor microenvironment (TME). To overcome this, we combined trackable intratumor microdosing (CIVOTM) with spatial biology readouts to directly assess drug effects in patient tumors in situ. Patients and Methods: In a first-of-its-kind Phase 0 clinical trial, we explored the effects of an investigational stage SUMOylation Activating Enzyme (SAE) inhibitor, subasumstat (TAK-981) in 12 patients with head and neck carcinoma (HNC). Patients scheduled for tumor resection received percutaneous intratumor injections of subasumstat and vehicle control 1 to 4 days prior to surgery, resulting in spatially localized and graded regions of drug exposure (~1000-2000 microns in diameter). Drug-exposed (n=214) and unexposed regions (n=140) were compared by GeoMx Digital Spatial Profiler, with evaluation at single cell resolution in a subset of these by CosMx Spatial Molecular Imager. Results: Localized regions of subasumstat exposure revealed SUMO pathway inhibition, elevation of Type I interferon (IFN-I) response, and inhibition of cell cycle across all tumor samples. Single cell analysis by CosMx demonstrated cell cycle inhibition specific to the tumor epithelium, and IFN pathway induction commensurate with a TME shift from immune-suppressive to immune-permissive. Conclusions: Pairing CIVO with spatial profiling enabled detailed investigation of response to subasumstat across a diverse sampling of native and intact TMEs. We demonstrate that drug mechanism of action can be directly evaluated in a spatially precise manner in the most translationally relevant setting: an in situ human tumor.
Supplementary Table 2 from CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer
Authors: Sozio Francesca , Schioppa Tiziana , Laffranchi Mattia , Salvi Valentina , Tamassia Nicola , Bianchetto-Aguilera Francisco M. , Tiberio Laura , Bonecchi Raffaella , Bosisio Daniela , Parmentier Marc , Bottazzi Barbara , Leone Roberto , Russo Eleonora , Bernardini Giovanni , Garofalo Stefano , Limatola Cristina , Gismondi Angela , Sciumè Giuseppe , Mantovani Alberto , Del Prete Annalisa , Sozzani Silvano
Published: July 2023

Supplementary Table 2
Supplementary Figures from CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer
Authors: Sozio Francesca , Schioppa Tiziana , Laffranchi Mattia , Salvi Valentina , Tamassia Nicola , Bianchetto-Aguilera Francisco M. , Tiberio Laura , Bonecchi Raffaella , Bosisio Daniela , Parmentier Marc , Bottazzi Barbara , Leone Roberto , Russo Eleonora , Bernardini Giovanni , Garofalo Stefano , Limatola Cristina , Gismondi Angela , Sciumè Giuseppe , Mantovani Alberto , Del Prete Annalisa , Sozzani Silvano
Published: July 2023

Supplementary Figures 1-7 with legends
Supplementary Table S7 from Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit
Authors: Bulen Benjamin J. , Khazanov Nickolay A. , Hovelson Daniel H. , Lamb Laura E. , Matrana Marc , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L. , Miller Alan M. , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D. , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A. , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C. , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R. , Tomlins Scott A.
Published: July 2023

Supplementary Table S7 shows a sub-group analysis of the PD-L1 IHC cohort
Supplementary Table S4 from Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit
Authors: Bulen Benjamin J. , Khazanov Nickolay A. , Hovelson Daniel H. , Lamb Laura E. , Matrana Marc , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L. , Miller Alan M. , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D. , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A. , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C. , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R. , Tomlins Scott A.
Published: July 2023

Supplementary Table S4 shows the characteristics of the patients used in the case cross-over analysis
Supplementary Table S3 from Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit
Authors: Bulen Benjamin J. , Khazanov Nickolay A. , Hovelson Daniel H. , Lamb Laura E. , Matrana Marc , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L. , Miller Alan M. , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D. , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A. , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C. , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R. , Tomlins Scott A.
Published: July 2023

Supplementary Table S3 shows unadjusted restricted mean survival time analysis of for real-world PFS and overall survival in the monotherapy validation cohort
Supplementary Table S12 from Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit
Authors: Bulen Benjamin J. , Khazanov Nickolay A. , Hovelson Daniel H. , Lamb Laura E. , Matrana Marc , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L. , Miller Alan M. , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D. , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A. , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C. , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R. , Tomlins Scott A.
Published: July 2023

Supplementary Table S12 shows a sub-group analysis of the chemotherapy, anti-PD-(L)1, and chemotherapy + anti-PD-(L)1 validation cohort
Supplementary Table S11 from Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit
Authors: Bulen Benjamin J. , Khazanov Nickolay A. , Hovelson Daniel H. , Lamb Laura E. , Matrana Marc , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L. , Miller Alan M. , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D. , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A. , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C. , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R. , Tomlins Scott A.
Published: July 2023

Supplementary Table S11 shows the characteristics of the chemotherapy, anti-PD-(L)1, and chemotherapy + anti-PD-(L)1 validation cohort
Supplementary Figure S7 from Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit
Authors: Bulen Benjamin J. , Khazanov Nickolay A. , Hovelson Daniel H. , Lamb Laura E. , Matrana Marc , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L. , Miller Alan M. , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D. , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A. , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C. , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R. , Tomlins Scott A.
Published: July 2023

Supplementary Figure S7. shows covariate adjusted Kaplan-Meier analysis of the chemotherapy, anti-PD-(L)1, and chemotherapy + anti-PD-(L)1 validation cohort
Supplementary Figure S3 from Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit
Authors: Bulen Benjamin J. , Khazanov Nickolay A. , Hovelson Daniel H. , Lamb Laura E. , Matrana Marc , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L. , Miller Alan M. , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D. , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A. , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C. , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R. , Tomlins Scott A.
Published: July 2023

Supplementary Figure S3 shows how Immunotherapy Response Score adds to tumor mutation burden and microsatellite instability status for anti-PD-(L)1 monotherapy clinical benefit
Supplementary Figure S2 from Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit
Authors: Bulen Benjamin J. , Khazanov Nickolay A. , Hovelson Daniel H. , Lamb Laura E. , Matrana Marc , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L. , Miller Alan M. , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D. , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A. , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C. , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R. , Tomlins Scott A.
Published: July 2023

Supplementary Figure S2 shows a diagram of the overall study
Supplementary Data S1 from Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit
Authors: Bulen Benjamin J. , Khazanov Nickolay A. , Hovelson Daniel H. , Lamb Laura E. , Matrana Marc , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L. , Miller Alan M. , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D. , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A. , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C. , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R. , Tomlins Scott A.
Published: July 2023

Supplementary Data S1 shows the REMARK checklist for the study
FIGURE 1 from Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit
Authors: Bulen Benjamin J. , Khazanov Nickolay A. , Hovelson Daniel H. , Lamb Laura E. , Matrana Marc , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L. , Miller Alan M. , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D. , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A. , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C. , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R. , Tomlins Scott A.
Published: July 2023

Validation of IRS to stratify anti-PD-(L)1 monotherapy benefit in patients with advanced solid tumors. A, Clinical characteristics of the anti-PD-(L)1 monotherapy validation cohort are shown in an alluvial diagram. All patients with available clinical molecular profiling data necessary for IRS (TMB and normalized expression of PD-1, PD-L1, ADAM12, and TOP2A from in-parallel qTP) from FFPE tumor tissue enrolled in the Strata Trial (NCT03061305) and treated with systemic anti-PD-(L)1 monotherapy were considered. Patients in previous IRS discovery or validation were excluded. The locked IRS model and thresholds were used to assign IRS-L (light blue) or IRS-H (increased benefit; dark blue) status. For the 352 eligible patients, IRS status, MSI/TMB status (MSI-H or TMB-H as MSI/TMB-H), type of anti-PD-(L)1 therapy [pembrolizumab (pembro) vs. other anti-PD-(L)1], systemic line of anti-PD-(L)1 therapy, and tumor type [all tumor types with >15 samples considered individually: NSCLC, cancer of unknown primary (CUP), bladder cancer (Blad.), melanoma (Mel.), head and neck cancer (H&N), and EGC; remaining 25 other tumor types considered together] are shown. Stratum are colored by IRS status. IRS stratifies anti-PD-(L)1 monotherapy clinical benefit by rwPFS (by time to next therapy; B) and OS (C). B, Anti-PD-(L)1 monotherapy rwPFS stratified by IRS group is shown by unadjusted Kaplan–Meier analysis, with the aHR [adjusted for age, sex assigned at birth, line of therapy, tumor type and anti-PD-(L)1 therapy type], 95% CI and P value for IRS status (IRS-H vs. IRS-L) shown. The number (n) of patients, events, and median rwPFS (with 95% CI) for each group are shown. Forest plot analyses of rwPFS by IRS status in key subgroups are shown below (Remaining 4 = Blad., Mel., H&N, and EGC). Significant associations are shown by filled in aHR estimates. C, As in B, except assessing OS.
Comparative analysis of THD for square-wave inverter at different conduction modes
Authors: Gupta Ranitesh , Sahay Kuldeep
Published: July 2023

This paper proposes conduction schemes for the most common six-switch voltage sources inverter. Also, a comparative study of the output THD for different conduction modes of switches for a three-phase square wave inverter is done, as the harmonic content of any electrical system is important to analyze its performance. The harmonic distortion of the load voltage and load current is taken as the main constraint to evaluate the performance of the three-phase inverter. So, control strategies for various loads are executed for different modulation schemes of inverter switches using MATLAB/Simulink software. Obtained results show that 150° conduction gives the least THD for output current, and 170° conduction gives the least THD for output voltage for three-phase inverters. Also, harmonic contents are reduced using a passive LC filter at the output of the inverter.
Behavioral responses of laboratory-reared and wild-caught Polypedates maculatus (Anura: Rhacophoridae) tadpoles to dietary cues from the carnivorous tadpoles of Hoplobatrachus tigerinus (Anura: Dicroglossidae)
Authors: Mogali Santosh M. , Shanbhag Bhagyashri A. , Saidapur Srinivas K.
Published: July 2023

The behavioral responses of laboratory-reared and wild-caught tadpoles of Polypedates maculatus to predatory tadpoles of Hoplobatrachus tigerinus were studied in the laboratory. The predator’s diet-derived metabolites released in excreta of predator after consumption of P. maculatus tadpoles were used to simulate predation threat. Both laboratory-reared and wild-caught tadpoles of P. maculatus showed antipredator behavioral responses i.e., reduced swimming movements and overall time spent in swimming and had a higher burst speed in response to water borne dietary cues of predators. Further, the antipredator responses of wild-caught tadpoles were significantly higher than those exhibited by laboratory-reared tadpoles. The studythus shows that antipredator behavior in these tadpoles is innate. Further, an enhanced antipredator behavior of wild-caught tadpoles may suggest their prior experience with predators in natural waters.
Morpheme Structure Constraints Solve Three Puzzles for Theories of Blocking in Nonderived Environments
Authors: Rasin Ezer
Published: July 2023

In nonderived environment blocking (NDEB), a phonological process applies across morpheme boundaries or morpheme-internally when fed by another phonological process but is otherwise blocked. I present a theory of NDEB that attributes blocking to an interaction between morpheme structure constraints (which constrain possible underlying representations in the lexicon) and the usual phonological mapping from underlying to surface forms. The theory has some unusual aspects that make it conceptually suspicious, but I will argue that it receives empirical support. Using several case studies, I discuss three puzzles for theories of NDEB previously proposed in the literature, including the Strict Cycle Condition (Mascarό 1976), Kiparsky’s (1993) theory of underspecification, Sequential Faithfulness (Burzio 2000), Colored Containment (Van Oostendorp 2007), and Optimal Interleaving with Candidate Chains (Wolf 2008). I show that none of those theories can deal with all three puzzles and that the proposed theory with morpheme structure constraints succeeds. This result supports a dual-component architecture of phonology (as in Chomsky and Halle 1968) over architectures that eliminate language-specific morpheme structure constraints (i.e., the principle of Richness of the Base in Optimality Theory).
The Ongoing Significance of Federalism to Australian Treaty Practice
Authors: Clough Georgina
Published: July 2023

This article considers the significance of Australia’s federal constitutional structure to its relationship with international law. It focuses specifically on how Australia’s federal system continues to influence Australia’s ability to assume, implement and comply with international obligations, by considering a series of examples in which states and territories have acted inconsistently with those obligations. It argues that understanding the domestic legal framework that governs how a state interacts with international law, as well as the political and historical contexts that inform how that framework actually operates, allows for greater insight into how that state relates to the international legal system.
The discarded cow from the flowered desert: revalidation of Gyriosomus crispaticollis Fairmaire, 1886 stat. rev. (Coleoptera: Tenebrionidae) in Southern Atacama, Chile
Authors: GUERRERO MARCELO , DIÉGUEZ VÍCTOR M. , ANGUITA-SALINAS SIMÓN , REINOSO ÁLVARO ZÚÑIGA-
Published: July 2023

Gyriosomus crispaticollis Fairmaire, 1886 is revalidated from the synonymy of Gyriosomus luczotii Guérin-Méneville, 1831 based on the study of G. crispaticollis syntypes and comparative morphological and genetic analyses. Our results suggest that G. crispaticollis is morphologically closer to Gyriosomus multigranulosus Pizarro-Araya & Flores, 2004 than G. luczotii, but genetically barely closer to G. luczotii. Also habitat preferences, field observations and lectotype designation are provided for G. crispaticollis.
Assessing the Comparative Effects of Storm-Relative Helicity Components within Right-Moving Supercell Environments
Authors: Goldacker Nicholas A. , Parker Matthew D.
Published: July 2023

Supercell thunderstorms develop low-level rotation via tilting of environmental horizontal vorticity (ωh) by the updraft. This rotation induces dynamic lifting that can stretch near-surface vertical vorticity into a tornado. Low-level updraft rotation is generally thought to scale with 0–500 m storm-relative helicity (SRH): the combination of storm-relative flow, |SRF|, |ωh|, and cosϕ (where ϕ is the angle between SRF and ωh). It is unclear how much influence each component of SRH has in intensifying the low-level mesocyclone. This study surveys these three components using self-organizing maps (SOMs) to distill 15 906 proximity soundings for observed right-moving supercells. Statistical analyses reveal the component most highly correlated to SRH and to streamwise vorticity (ωs) in the observed profiles is |ωh|. Furthermore, |ωh| and |SRF| are themselves highly correlated due to their shared dependence on the hodograph length. The representative profiles produced by the SOMs were combined with a common thermodynamic profile to initialize quasi-realistic supercells in a cloud model. The simulations reveal that, across a range of real-world profiles, intense low-level mesocyclones are most closely linked to ωh and SRF, while the angle between them appears to be mostly inconsequential.

Significance Statement

About three-fourths of all tornadoes are produced by rotating thunderstorms (supercells). When the part of the storm near cloud base (approximately 1 km above the ground) rotates more strongly, the chance of a tornado dramatically increases. The goal of this study is to identify the simplest characteristic(s) of the environmental wind profile that can be used to forecast the likelihood of strong cloud-base rotation. This study concludes that the most important ingredients for storm rotation are the magnitudes of the horizontal vertical wind shear between the surface and 500 m and the storm inflow wind, irrespective of their relative directions. This finding may lead to improved operational identification of environments favoring tornado formation.
The Opium Wars of China in the Nineteenth Century and America in the Twenty-First
Authors: Nakayama Don K.
Published: July 2023

The Opium Wars of 1839-1843 and 1856-1860 revealed the devastating effects of narcotic addiction on the health of the body politic of China. The defeated Qing dynasty lost effective sovereignty to the British, leaving it helpless against more than 100 years of exploitation by the European powers, the United States, and Japan. Today we see the same risk posed by prescription narcotics and illegal opioids imported from China that can be seen as retribution for the “Century of Humiliation” nearly two centuries ago.
Fostering Drivers’ Trust in Automated Driving Styles: The Role of Driver Perception of Automated Driving Maneuvers
Authors: Ma Zheng , Zhang Yiqi
Published: July 2023

Objective

This study investigated the impact of driving styles of drivers and automated vehicles (AVs) on drivers’ perception of automated driving maneuvers and quantified the relationships among drivers’ perception of AV maneuvers, driver trust, and acceptance of AVs.

Background

Previous studies on automated driving styles focused on the impact of AV’s global driving style on driver’s attitude and driving performance. However, research on drivers’ perception of automated driving maneuvers at the specific driving style level is still lacking.

Method

Sixteen aggressive drivers and sixteen defensive drivers were recruited to experience twelve driving scenarios in either an aggressive AV or a defensive AV on the driving simulator. Their perception of AV maneuvers, trust, and acceptance was measured via questionnaires, and driving performance was collected via the driving simulator.

Results

Results revealed that drivers’ trust and acceptance of AVs would decrease significantly if they perceived AVs to have a higher speed, larger deceleration, smaller deceleration, or shorter stopping distance than expected. Moreover, defensive drivers perceived significantly greater inappropriateness of these maneuvers from aggressive AVs than defensive AVs, whereas aggressive drivers didn’t differ significantly in their perceived inappropriateness of these maneuvers with different driving styles.

Conclusion

The driving styles of automated vehicles and drivers influenced drivers’ perception of automated driving maneuvers, which influence their trust and acceptance of AVs.

Application

This study suggested that the design of AVs should consider drivers’ perceptions of automated driving maneuvers to avoid undermining drivers’ trust and acceptance of AVs.
Essentially Aggregative Harm, Restraint, and Collectivization
Authors: Kahn Elizabeth
Published: July 2023

Some of the most pressing contemporary social problems result from the amalgamation of a mass of actions that are not intentionally coordinated. Although these essentially aggregative harms are foreseeable, it is unclear what moral duties individuals have with regards to them. This paper offers a new analysis of these problems and uses a nonideal contractualist approach to argue in favour of two kinds of duties for individuals. Collectivization duties that require individuals to act responsively with a view to ensuring that there are effective governance agents that reliably, fairly, and efficiently prevent these outcomes in the long-term and duties of restraint that require individuals to avoid action of a kind that is likely to come together with other actions to cause serious EAH in the immediate future when restraint with regards to actions of this kind could help prevent the outcome from occurring.
High density polyethylene and butanol-gasoline blends: A material compatibility study
Authors: Nair Preeti , HN Meenakshi
Published: July 2023

We are now well on the path of transitioning away from the fossil fuel resources on cutting down their consumption as much as possible. The fuels chosen for this study include ethanol-butanol (EB) -gasoline, acetone-butanol-ethanol (ABE) -gasoline and methanol-butanol (MB) -gasoline blends. High density polyethylene (HDPE) is a polymer that is extensively used in several auto parts and fuelling infrastructure materials. Incompatibility between these blends and fueling infrastructure system should be studied comprehensively for the adoption of these alternative fuels to be faster and hassle free. This study intends to gauge the changes in HDPE because of its immersion in the gasoline-alcohol blends mentioned for a period of 4, 30 & 90 days. The changes were ascertained by studying the mass, tensile strength, elongation, and hardness of the samples before and after immersion into blends. Sophisticated techniques were used to characterize the morphological and chemical changes of the polymer. The results showed that there was an increase in the mass of the HDPE samples as a result of the absorption of the blends by the polymeric samples. A decrease in tensile strength and hardness values were recorded for the samples whereas the elongation values were found to increase. Studies revealed that there was neither fuel degradation nor any oxidative degradation of the polymeric sample. The results indicated an increase in the mass and elongation of the HDPE as a result of the absorption of the fuel leads to lesser stable polymeric matrix and decrease in the percentage crystallinity. Hence this investigation led us to the conclusion that all the fuels blends studied are highly compatible with HDPE, even in instances where a change in the mechanical properties is seen, it is similar to that seen in gasoline.
Multi-attribute Probabilistic Neural Network Reservoir Prediction Based on Mudstone Acoustic Time Difference Decompaction Correction
Authors: Guo Feng , Yang Xudong , Guo Ling , Lai Shenghua
Published: July 2023

In order to accurately predict reservoirs with similar physical properties between sandstone and surrounding rocks, this study takes Carboniferous-Permian system in southeastern Ordos Basin as an example, and puts forward a multi-attribute probabilistic neural network prediction method based on acoustic time difference compaction correction. Firstly, the time-frequency analysis method is used to divide the frequency of the original acoustic time difference curve, and the low-frequency long-trend correction of all wells is carried out based on the low-frequency components of standard wells. Then, it is frequency-divided and fused with the original high-frequency components to form new acoustic time difference data, and the long-term trend decompaction correction of acoustic time difference is completed, so that the overlapping area of acoustic time difference between reservoir and surrounding rock is reduced. Multi-attribute probabilistic neural network is an algorithm based on sampling points, before reservoir prediction, inversion parameters must be optimized to save calculation time and reduce prediction error. There is a high correlation between longitudinal velocity and lithologic change trend on the inversion profile of sound velocity. The comparison results of various inversions show that the velocity profile of multi-attribute probabilistic neural network has the highest coincidence rate and high resolution with the velocity curve of logging acoustic wave. The example shows that this method has high accuracy in predicting reservoir thickness, especially for the strata with little difference in physical properties between reservoir and surrounding rock.
Women Academics in Theological and Mission Organisations
Authors: Moseley Anne , Oxbrow Mark
Published: July 2023

This paper reports on a small-scale inquiry into the experience of female scholars undertaking post-graduate research in a British mission research centre working primarily with students from international backgrounds. Drawing on previous research literature, survey and interview data is used to identify social, financial, gendered and theological factors that impact women in terms of their entry into academia, flourishing and advancement in that contact. It suggests that academic institutions, systemic processes and measures of achievement are currently largely ‘designed by men for men’ and act to exclude women who do not approach research within male structures. It suggests that measures of achievement are different for men and women and that there are systemic issues in an academic system designed by men which are restrictive for men as well as women. A healthy academic institution needs to value mutual support, accomplishment and belonging, providing mentors, role models and networks of support.
Current Benefits of ASCE 75 and its Potential to Affect Digital As-Built Initiatives at State Departments of Transportation
Authors: Patel Parshva , Sturgill Roy , Nassereddine Hala , Ramadan Bassam , Li Ying
Published: July 2023

For the proactive documentation of utility infrastructure at the time of its installation, the American Society of Civil Engineering (ASCE) is finalizing their ASCE 75 “Standard Guideline for Recording and Exchanging Utility Infrastructure Data.” ASCE 75 provides guidance for collecting sufficient geospatial and attribute data of utilities to facilitate the development of precise 3D digital twins. Some state departments of transportation (DOTs) in the U.S. have already adopted draft versions of ASCE 75 and are attempting to use it to assist their efforts to standardize and expedite their utility accommodation, permitting, and highway project coordination regulations and procedures. In alignment with these efforts, the Federal Highway Administration’s “Every Day Counts Round Six” initiative illustrates the importance of digital as-built (DAB) records by stating that their implementation can enhance safety, quality, and cost savings. However, there is no standard practice for the general construction DABs. Therefore, this study illustrates the benefits of implementing the ASCE 75 utility as-built standard and its potential impact on DABs for general construction. This study used a research methodology comprised of interviewing state DOTs, and a comprehensive literature assessment. The benefits of implementing ASCE 75 include improved data exchange methods among the project stakeholders and the collection and exchange of data about subsurface and above-ground utilities’ location and other attributes. Moreover, ASCE 75 provides a framework for all infrastructure projects. Also, the study highlights how ASCE 75 is adopted across the state DOTs and how it presents a path forward beyond just developing a utility as-built standard.
The Influence of Parenting Styles on Early Adolescence Volunteering
Authors: Mantovan Noemi , Sauer Robert M. , Wilson John
Published: July 2023

Volunteer work among early adolescents has been largely neglected as a research topic. This study examines the influence parents have on their children’s volunteer activities when they are between 10 and 15, with a special focus on the difference made by parental styles. Data are drawn from a subsample of respondents in the U.K. Household Longitudinal Study. Controlling for parent’s volunteering, social class, and religiosity, sons are encouraged to volunteer by authoritative fathers and discouraged from volunteering by authoritarian fathers. Mothers’ parenting styles have no influence on their children’s volunteering, and permissive parenting by either parent has no influence on volunteering of either boys or girls.