bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Resource Management Problems for Private Madrasah Aliyah Teachers in Regency
Authors: Fitria Nor , Istikomah
Published: October 2022

Management is the process of utilizing all the resources owned by the organization to achieve the goals that have been set. management in a broad sense is planning, organizing, directing, and controlling organizational resources to achieve goals effectively and efficiently. The objectives of this study are to describe the problems of teacher human resource management at private madrasah aliyah in Sampang regency. This study uses a qualitative approach, which aims to explain the problem of human resource management for private Madrasah aliyah teachers, a qualitative approach is considered a research procedure that produces descriptive data in the form of words from observations, interviews and documentation. Data collection techniques by reviewing documents, interviews, and observations. It is analyzed through the following stages: data reduction, data presentation, and verification.  The results of this study indicate that the problem with teacher human resources is that the number of teachers who teach is not in accordance with their academic qualifications because the management function of teacher human resources in madrasah aliyah does not run optimally starting from planning, management, procurement, procurement, development, assessment, control, compensation and dismissal. and the causes of the problem of teacher human resources are divided into two factors, namely internal factors, the character of teachers, lack of teacher innovation, lack of motivation and indifference to various changes, limited funds available while external causes such as Madrasah environmental conditions and conditions of socio-cultural development of the community, lack of continuous support from organization in teacher HR Management.
The Role of Diniyah Madrasah Teachers in Fostering Discipline in Student Learning at Islamic Boarding Schools
Authors: Aini Lisa Nur , Fahyuni Eni Fariyatul
Published: October 2022

Students' learning discipline is the obedience of students to carry out their learning obligations, so they can get changes in themselves, both studying at home and in Islamic boarding schools. Madrasah diniyah teachers have a very big responsibility in disciplining their students to obey the rules that exist in Islamic boarding schools. Therefore, this study aims to determine the role of madrasah diniyah teachers in fostering student learning discipline as well as supporting and inhibiting factors in fostering student learning discipline. This research is a descriptive qualitative research, namely research that describes the reality and circumstances of the object of research in accordance with the facts in the field by taking data that is what it is. In this study, the informants were madrasah diniyah administrators, madrasah diniyah teachers, and students of Islamic boarding schools. The location of this research was conducted in Paciran Village, Paciran District, Lamongan Regency. Data collection techniques are interviews, observation, documentation. The data collection technique uses Miles and Huberman which consists of four components of analysis, namely data reduction, data presentation, conclusion drawing, data int erpretation. Based on the research that has been done, there are research results, namely: 1). The role of madrasah diniyah teachers in fostering learning discipline for students at the Muhammadiyah Karangasem Islamic boarding school. 2). How the supporting and inhibiting factors for madrasah diniyah teachers in fostering student learning discipline include the teacher in teaching, the suitability of the subject matter to be delivered, and sufficient learning time.
Islamic Religious Education in Indonesian Society
Authors: Saifuddin  , Fahyuni Eni Fariyatul
Published: October 2022

Education in Islam is very important for human life. There are so many arguments in the Qur'an and hadith that explain the concept of education. Education is important and urgent because the current condition of society is only concerned with knowledge but must pay attention to moral development, morals, and behavior. That's all there is Islamic religious education. This study aims to find out about the implementation of Islamic education in the wider community. The sociological approach in understanding Islam is very important because there are so many religious teachings related to social problems. The research method used is library research. All data obtained and collected are then analyzed and presented from various journal articles that complement the data to provide conclusions. Then reviewed and presented the findings of the data objectively. This study indicates that Islamic religious education is needed by everyone first in social life in Indonesia, which in fact, there are many groups or ethnic groups in Indonesia. The study results show that Islamic religious education is very important in social life in Indonesia because Islamic religious education can make people behave well and follow the rules that exist in Islam.
The Role of Islamic Religious Education Teachers in the Development of Religious Characters in Limited Face-to-Face Learning at Senior High School
Authors: Azizah Rahma Septia , Anshori Isa
Published: October 2022

This study aims to explore and understand the role of PAI teachers in fostering religious character during PTMT with a hybrid learning model at SMA Antartika Sidoarjo and to find out the supporting and inhibiting factors. The research method used is descriptive qualitative which produces data in the form of written words from the results of interviews, observations and documentation. The results showed that PAI teachers in fostering religious character in PTMT with a hybrid learning model at SMA Antartika Sidoarjo have been able to foster and guide, provide exemplary examples and advice, remind students to behave Islamically in daily life, provide adequate facilities and provide rewards and punishments. for students through the implementation of religious programs, namely congregational prayers, collective prayers, reading and writing the Qur'an, Friday blessing activities, extra religious activities, annual religious activities and the creation of a religious atmosphere at SMA Antarctica Sidoarjo. Several factors that support and inhibit are divided into two factors, namely internal and external. The supporting factors are more dominant on internal factors where the school environment can help optimally to realize the development of students' religious character. While the inhibiting factors are more dominant on external factors, namely the family environment and social environment wherever students are.
The Influence of Spirituality, Colleagues and Organizational Culture on Job Satisfaction of Madrasah Diniyah Teachers
Authors: Rois Mohammad Ma’ruf , Sumartik
Published: October 2022

This study aims to determine the effect of Spirituality, Colleagues, and Organizational Culture on Teacher Job Satisfaction at Madrasah Diniyah Salafiyah Ar-Riyadl, Jabon District. This research is included in the type of quantitative research with hypothesis testing. The sample used in this study were 50 respondents. The sampling technique used was non-probability sampling technique. The analytical tool used in this research is a path analysis technique with the help of software for the operating system called Smart-PLS (Partial Least Square) Version 3.0. The data used in this research are questionnaire data and data sourced from Madrasah Diniyah Salafiah Ar-Riyadl, Jabon District. Data collection techniques using questionnaires. The results of this study prove that Hypothesis 1: spirituality variable has no effect on job satisfaction. Hypothesis 2: coworkers affect job satisfaction. Hypothesis 3: organizational culture has an effect on job satisfaction.
The Implementation Of The Semester Credit System Program 2 Year At The State Madrasah Aliyah
Authors: Anisah Lutfia Nur , Istikomah
Published: October 2022

The purpose of this study was to determine the implementation of the 2 year Semester Credit System (SKS) Program at Madrasah Aliyah Negeri Surabaya. This research method is using qualitative research with a descriptive approach. This research uses a type of field research (field research) using data collection methods through observation, interviews and documentation. The results of this study indicate that the 2 year SKS (SKS) Program can be said to be effective, this is evidenced by the service of educators, student academic competence and adequate facilities and infrastructure. In the implementation of Fiqh learning in the 2-year credit program, it has been effective. The lesson plans are described in a learning component that has been prepared by the respective subject teachers. The descriptions are in the form of promissory notes, prota, SK, KD, RPP. Evaluation in the SKS program is by providing intense services to students who have scores below the average while the evaluation in the field of Jurisprudence is carried out in the middle of the semester, namely the Mid-Semester Examination (UTS) and the Final Semester Examination (UAS) using both written and written test techniques. oral test and hands-on practice. For assessment in the field of Jurisprudence, the teacher takes cognitive, affective and psychomotor assessments.
Curriculum Development of Madrasah Diniyah
Authors: Wardany Vania Putri Kusuma , Istikomah
Published: October 2022

Madrasah Diniyah is a non-formal educational institution that uses a curriculum that can be developed by the institution itself in accordance with the characteristics of each. The purpose of this studyonly focus on the process, implementation, barriers to curriculum development at Madrasah Diniyah Salafiyah Mamba'us Sa'adah, the type of research using RND (Research and Development), data collection techniques using interview, observation, documentation and library studies. The data analysis technique uses a rocket scale. Based on the results of the study, it can be concluded that Madrasah Diniyah Salafiyah Mamba'us Sa'adah has undergone curriculum development from year to year starting from the objectives, content, methods and learning strategies. Supporting the development of the Madrasah Diniyah Salafiyah Mamba'us Sa'adah curriculum is the existence of Ustad/zah, Santri, complete facilities and support from parents, the community. The obstacles include student discipline, government funds, and inadequate building infrastructure.
Application of Blended Learning on Arabic Language Learning during the Covid-19 Pandemic 4th grade in Elementary School
Authors: Muniroh Novia Lu’lu’ul , Anwar Najih
Published: October 2022

The obstacles to learning during the covid-19 pandemic were especially limited to fourth-grade Arabic learning at muhammadiyah elementary school. 11 randegan. This article aims to identify the process, the contributing factors and the retardential factors in the learning of arabic. 11-randegan class 4 student student at muhammadiyah elementary school. The methods used are descriptive qualitative methods using methods of observation, interview, and documentation. Efforts made that the process of applying blended learning to Arabic learning are three stages: the process of planning, implementation and evaluation. As for the supporting factors of teachers and technology, while the inhibitory factors of Internet connection, short time and lack of student motivation.
Al-Qur'an Learning with the Yanbu'a Model for the Quality of Pronunciation of Hijaiyah Letters at Islamic Boarding Schools
Authors: Devi Sylvia Candra , Romadlon Dzulfikar Akbar
Published: October 2022

This study aims to determine the learning of the Koran with the yanbu'a model for the quality of the pronunciation of hijaiyah letters at the Ar-Roudhoh Krian Sidoarjo Islamic Boarding School and to find out the supporting and inhibiting factors in its application. The research method used is descriptive qualitative which produces data in the form of written words from the results of interviews, observations and documentation. The results showed that: (1) The application of the Yanbu'a model used 3 classical models, sorogan, and tadarus. Although the learning of the Qur'an was carried out well, phonological errors were found in the pronunciation of the hijaiyah letters, namely consonant errors and vowel errors. (2) The supporting factors are in practice using many variations and supported by khataman activities and giving awards to students who have achieved the memorization target. While the inhibiting factor is the application of existing regulations during the learning process of the Al-Qur'an pronunciation of the hijaiyah letters that are not enforced to students, especially the inadequate facilities and infrastructure so that the yanbu'a model for the quality of the pronunciation of the hijaiyah letters is less than optimal.
The Relationship Between Self-Efficacy and Subjective Welfare of Adolescent Santri in Islamic Boarding Schools
Authors: Rahmawati Safera Dwi Intan , Hazim Hazim
Published: October 2022

This study aims to determine the relationship between self-efficacy and subjective well-being in adolescent students at Pondok An-Nur Sidoarjo. This type of research is quantitative correlational. The variables in this study are self efficacy (x) and subjective well being (y). The study was conducted at the An-Nur Islamic Boarding School, Sidoarjo with a population of 190 teenage students. a sample of 123 teenage students using simple random sampling. The data collection technique uses a psychological scale with a Likert scaling model, namely the self-efficacy scale and the subjective well-being scale. The hypothesis in this study is that there is a positive relationship between self-efficacy and subjective well-being in adolescent students at Pondok An-Nur Sidoarjo. Data analysis used product moment correlation technique with the help of SPSS 25 for windows program. The results of data analysis correlation value of 0.883 with a significance of 0.000 <0.05, meaning that there is a positive relationship between self-efficacy and subjective well-being in adolescent students at Pondok An-Nur Sidoarjo. The higher the self efficacy, the higher the subjective well being. On the other hand, the lower the self-efficacy, the lower the subjective well-being of adolescent students.
Description of Subjective Welfare of Santri at Islamic Boarding Schools
Authors: Kusuma Mahestining Kaluni Indah , Mariyati Lely Ika
Published: October 2022

Adolescents need high subjective well-being because adolescence is a transition period from childhood to adulthood so that they are vulnerable to various problems. The same applies to teenage students who live in Islamic boarding schools. This study aims to determine the description of subjective well being in adolescent students at Pondok Pesantren An - Nur Sidoarjo. The number of subjects in this study were 123 students using the proportional stratified random sampling technique from 190 total populations. Collecting data using a Likert scale model on the subjective well being variable. The research analysis uses descriptive analysis method with a quantitative approach and utilizes the help of SPSS 25.0 for Windows. The results of this study indicate that most of the subjective well being students are in the moderate category with a percentage of 38% of 47 students. The next result is a description of subjective well being based on gender and age. Subjective well being based on gender shows that the value of Sig. (2-tailed) 0.023 <0.05, then there is a significant difference between the subjective well being of male students. Subjective well being based on the age factor of the students at the An-Nur Islamic Boarding School can show that the value of Sig. 0.000 <0.05, it can be concluded that the average subjective well being based on age is significantly different.
INTEGRATING EXPERIMENTS WITH SUBTIDAL DEATH ASSEMBLAGES TO UNVEIL THE PREDATORY HABITS OF MURICID GASTROPODS FROM THE SOUTHEASTERN PACIFIC
Authors: MARTINELLI J.C. , RUZ C.S. , PÉREZ-MATUS A. , RIVADENEIRA M.M.
Published: October 2022

As quantitative tools, drill holes have been used to calculate predation frequencies in time and space. These traces can also inform predator preference and some strategies predators use to drill on prey (e.g., edge drilling, site stereotypy, or alternative modes of predation when there is no drill hole). In this study, our goal was to leverage the informative power of drill holes to characterize the predatory habits of muricid gastropods from the central coast of Chile. We integrated information from experiments and death assemblages (DAs) to unveil the predatory strategy of Ancathina monodon, Crassilabrum crasilabrum, and Concholepas concholepas on the mobile gastropod Tegula tridentata and the sessile bivalve Perumytilus purpuratus. Experiments supported previous findings for predatory strategies (basal spine for Ancathina and alternative modes of predation for Concholepas), and showed the stereotypic predation of Crassilabrum on Tegula—a herbivore that is devastating subtidal kelp forests. Based on drill holes from DAs, at least 11 molluscan families are consumed by muricids in these communities. DAs also helped validate the stereotypic predation of Crassilabrum on Tegula, as drill holes were found in the same position both in experiments and DAs. Despite their thinner shells, mytilids were well represented in DAs and were found with drill holes in the five locations sampled. We describe for the first time the predatory strategy of Crassilabrum in Chile and confirm that muricids other than Concholepas are active predators on subtidal rocky habitats from the southeastern Pacific Ocean, a region that is still understudied.
LEAVES IN IRON OXIDE: REMARKABLE PRESERVATION OF A NEOGENE FLORA FROM NEW CALEDONIA
Authors: LOCATELLI EMMA R. , BRIGGS DEREK E.G. , LESLIE ANDREW , MUNZINGER JÉRÔME , GRANDCOLAS PHILIPPE , LOWRY PORTER P. , CANTRILL DAVID J. , MAURIZOT PIERRE , CLUZEL DOMINIQUE , FOLCHER NICOLAS , GARROUSTE ROMAIN , NEL ANDRÉ
Published: October 2022

A Neogene hematite-goethite concretionary ‘ironstone' horizon in laterized fluvial sediments in the Massif du Sud of New Caledonia yields abundant fossil dicotyledonous angiosperm leaves. The leaves are preserved in iron oxide, mainly goethite, which replicates the morphology and anatomy of the leaf tissues and comprises 73% of the matrix. Organic remains are minimal and associated with aluminosilicate clay. Leaf tissues are preserved three-dimensionally in multiple ways including casts/molds, permineralization/petrifaction, and replacement. Although the mesophyll is less well preserved, reflecting its greater susceptibility to decay, cellular details of vascular and epidermal tissues are commonly evident. Analyses of leaves from an analogous modern setting reveal the early encrustation and impregnation of tissues by amorphous iron-oxides and clays in association with a microbial biofilm. We propose a taphonomic model in which the fossil leaves, like their modern counterparts, were permeated by iron oxides due to the high availability of iron derived from weathering of ultramafic basement. In contrast to the iron-rich aluminosilicate coatings that form in relatively iron-poor settings, the unusually high concentration of dissolved iron oxides permitted rapid anatomical preservation.
Mapeando histórias de refugiados venezuelanos
Authors: Cirqueira André , Rizzi Calos
Published: October 2022

Este plano de aula é proposto para estudantes do 8º ano (ensino fundamental), buscando explorar a temática de refugiados venezuelanos a partir da construção de mapas mentais. Objetiva-se com isso a sensibilização das histórias dos refugiados, assim como, compreender as dinâmicas inerentes a este tipo de migração. Esta abordagem, utilizando uma metodologia ativa, entende que para esta etapa de ensino, conceitos relacionados a movimentos migratórios já foram apresentados aos estudantes em outros momentos da sua vida estudantil e, por isso, se propõe aqui um olhar reflexivo ao dilema dos refugiados venezuelanos. Para atingir tal objetivo de compreensão dos alunos, o plano de aula propõe a construção de um “Story Maps” e do mapa mental coletivo como forma de transcender o entendimento dos movimentos migratórios para além das causas e consequências do fenômeno, sensibilizando a percepção dos estudantes quanto as dificuldades enfrentadas pelos refugiados no trajeto Venezuela-Brasil e, com isso, proporcionar aprendizagem significativa dentro de uma perspectiva cartográfica.
Interventions and practices using Comfort Theory of Kolcaba to promote adults’ comfort: an evidence and gap map protocol of international effectiveness studies
Authors: Lin Yanxia , Zhou Yi , Chen Can
Published: October 2022

Background: Comfort is a primary patient objective and central to patient experience and thus maximising comfort is a universal goal for healthcare. However, comfort is a complex concept that is difficult to operationalise and evaluate, resulting in a lack of scientific and standardised comfort care practices. The Comfort Theory developed by Kolcaba has been the most widely known for its systematization and projection and most of the global publications regarding comfort care were based on this theory. To develop international guidance on theory-informed comfort care, a better understanding about the evidence on the effects of interventions guided by the Comfort Theory is needed.
Objectives: To map and present the available evidence on the effects of interventions underpinned by Kolcaba’s Comfort theory in healthcare settings
Methods: The mapping review will follow Campbell Evidence and Gap Maps guideline and Preferred Reporting Items for Systematic Reviews and Meta- Analyses extension for Scoping Reviews Protocols guidelines. An intervention-outcome framework has been developed based on Comfort Theory and the classification of pharmacological and non-pharmacological interventions via consultation with stakeholders. Nine electronic databases (MEDLINE, CINAHL, PsycINFO, Embase, AMED, Web of Science, Scopus, CNKI, Wan Fang) and grey literature sources (Cochrane Library, and JBI Library of Systematic Reviews, Google Scholar, Baidu Scholar. The Comfort Line) will be searched for primary studies and systematic reviews between 1991-2022 written in English and Chinese. Additional studies will be identified by reference list review of included studies. Key authors will be contacted for unpublished or ongoing studies. Two independent reviewers will screen and extract data using piloted forms with discrepancies resolved by discussion with a third reviewer. A matrix map with filters of study characteristics will be generated and presented through software of EPPI‐Mapper and NVivo.
Discussion: More informed use of theory can strengthen improvement programmes and facilitate the evaluation of their effectiveness. Findings from the evidence and gap map will present the existing evidence base for researchers, practitioners and policy makes, inform further research as well as clinical practices aiming at patients’ comfort enhancement.
Geo-epidemiology of malaria incidence in the Vhembe District to guide targeted elimination strategies, South-Africa, 2015-2018: a local resurgence
Authors: Dieng Sokhna , Adebayo-Ojo Temitope Christina , Kruger Taneshka , Riddin Megan , Trehard Helene , Tumelero Serena , Bendiane Marc-Karim , De Jager Christiaan , Patrick Sean , Bornman Riana , Gaudart Jean
Published: October 2022

Background
In South Africa, the population at risk of malaria is 10% (around six million inhabitants) and concern only three provinces of which Limpopo Province is the most affected, particularly in Vhembe District. To accelerate the elimination process, local targeting is necessary. There are no studies on malaria incidence at locality level, due to difficulty of population availability at this scale. The aim of this study was to identify and describe malaria incidence patterns at the locality scale in the Vhembe District.
Method
The study area comprised 474 localities in Vhembe District for which smoothed malaria incidence curve were fitted with functional data method based on their weekly observed malaria incidence from July 2015 to June 2018. Then, hierarchical clustering algorithm was carried out considering different distances to classify the 474 smoothed malaria incidence curves. Thereafter, validity indices were used to determine the number of malaria incidence patterns.
Results
The cumulative malaria incidence of the study area was 4.1 cases/1000 person-years. Four distinct patterns of malaria incidence were identified: high, intermediate, low and very low with varying characteristics. Malaria incidence increased across transmission seasons and patterns. The localities in the two highest incidence patterns were mainly located around farms, and along the rivers. Some unusual malaria phenomena in Vhembe District were also highlighted as resurgence.
Conclusion
Four distinct malaria incidence patterns were found in Vhembe District with varying characteristics. Findings show also unusual malaria phenomena in Vhembe District that hinder malaria elimination in South Africa. Assessing the factors associated with these unusual malaria phenome would be helpful on building innovative strategies that lead South Africa on malaria elimination.
Variable Curvature Modeling Method of Soft Continuum Robots with Constraints
Authors: Liu Yuwang , Shi Wenping , Chen Peng , Cheng Liang , Ding Qing , Deng Zhaoyan
Published: October 2022

The inherent compliance of continuum robots holds great promise in the fields of soft manipulation and safe human-robot interaction. This compliance reduces the risk of damage to the manipulated object and the surroundings. However, continuum robots have theoretically infinite degrees of freedom, and this high flexibility usually leads to complex deformations with external forces and positional constraints. How to describe this complex deformation is the main challenge for modelling continuum robots.
In this study, we investigated a novel variable curvature modeling method for continuum robots, considering external forces and positional constraints. The robot configuration curve is described by the developed mechanics model, and then the robot is fitted to the curve. To validate the model, a 10-section continuum robot prototype with a length of 1m was developed. The ability of the robot to reach the target points and track complex trajectories with load verified the feasibility and accuracy of the model. This work maight serve a new perspective for design analysis and motion control of continuum robots.
Parishin A-loaded Mesoporous Silica Nanoparticles Modulate Macrophage Polarization to Attenuate Tendinopathy
Authors: Liu Yan , Zhu Lisha , Jin Shanshan , Wang Yu , Niu Yuting , Yu Ming , Li Zixin , Chen Liyuan , Wu Xiaolan , Ding Chengye , Wu Tianhao , Shi Xinmeng , Zhang Yixin , Luo Dan
Published: October 2022

Macrophages are involved mainly in the balance between inflammation and tenogenesis during the healing process of tendinopathy. However, there is still lack of etiological therapeutic strategies to modulate macrophage state to treat tendinopathy efficiently. Here, we find that a small molecule compound Parishin-A (PA) isolated from Gastrodia elata could promote anti-inflammatory M2 macrophage polarization by inhibiting gene transcription and protein phosphorylation of signal transducers and activators of transcription 1. Local injection or sustained delivery of PA by mesoporous silica nanoparticles (MSNs) could almost recover the native tendon’s dense parallel-aligned collagen matrix in collagenase-induced tendinopathy by modulating macrophage-mediated immune microenvironment and preventing heterotopic ossification. Especially, MSNs decrease doses of PA, frequency of injection and yield preferable therapeutic effects. Mechanistically, intervention with PA could indirectly inhibit activation of mammalian target of rapamycin to repress chondrogenic and osteogenic differentiation of tendon stem/progenitor cells by influencing macrophage inflammatory cytokine secretion. Together, pharmacological intervention with natural small-molecule compound to modulate macrophage status appears to be a promising strategy for tendinopathy treatment.
Comprehensive analysis of m6A related gene mutation characteristics and prognosis in colorectal cancer
Authors: Jiang Tao , Xing Linshuai , Zhao Lipeng , Ye Ziqi , Yu Dong , Lin Shengtao
Published: October 2022

Background
Colorectal cancer (CRC) is considered as the second most common cancer worldwide. M6A RNA methylation is involved in diverse biological processes. Studies have shown that m6A RNA methylation abnormalities play an important role in the pathogenesis of many human diseases, including cancer. The current study was designed to characterize the mutation of m6A related genes and explore their prognostic role in colorectal cancer.
Methods
RNA-seq data and somatic mutation data of TCGA-COAD and TCGA-READ were downloaded from UCSC xena for comprehensive analysis. M6A related genes were selected from previous literatures, including "Writer" protein (METTL3, METTL5, METTL14, METTL16, ZC3H13, RBM15, WTAP, KIAA1429), "Reader" protein YTHDF1、YTHDF2、YTHDF3、YTHDC1、YTHDC2、HNRNPC、IGF2BP1、IGF2BP2、IGF2BP3), and "Eraser" protein (FTO、ALKBH5). Univariate Cox regression analysis and Kaplan-Meier were used to explore the correlation between m6A-related genes and colorectal cancer prognosis. The correlations between m6A-related genes and clinical parameters and immune-related indicators were explored by Spearman correlation analysis.
Results
In CRC, the expressions of m6A-related genes were significantly different between CRC and normal control except METTL14、YTHDF2、YTHDF3. Some of CRC patients (178 in 536) have a m6A-related genes mutation. ZC3H13 has highest mutation frequency of all m6A-related genes. M6A-related genes mainly enrich in regulation of mRNA metabolic process pathway. Patients with high expressions of FMR1、LRPPRC、METTL14、RBMX 、YTHDC2、 YTHDF2、YTHDF3 have poor prognosis in CRC. There was a significant correlation between the FMR1、LRPPRC、RBMX 、YTHDC2、 IGF2BP1 expression and the clinical characteristics of CRC. In addition, these genes are significantly associated with immune-related indicators. According to the expression patterns of FMR1, LRPPRC, RBMX, YTHDC2, and IGF2BP1, patients with CRC were clustered into two groups, and their survival was significantly different. By evaluating the tumor microenvironment in two clusters using ssGSEA, expressions of immune checkpoints and GSVA enrichment analysis, we observed that the immune and stem cell index of two cluster were much different.
Conclusion
Our study identified novel prognostic markers associated with immune of CRC cancer patients. Moreover, the potential mechanisms of prognostic markers in regulating the etiology of CRC cancer were investigated. These findings enrich our understanding of the relationships between m6a related genes and CRC, and may provide novel ideas in the therapy of CRC patients.
Avoiding extraction of severely damaged teeth: Impact of crown-root ratio altering apical root resection, orthodontic extrusion, and surgical crown lengthening on load capability
Authors: Naumann Michael , Adali U. , Rosentritt M. , Happe A. , Frankenberger R. , Sterzenbach G.
Published: October 2022

Objectives

to investigate the biomechanical impact of procedures changing crown-to-root ratio (RCRR) aimed to restore severely damaged upper central incisors to avoid tooth extraction compared to implant placement. There is no evidence on load capability after apical root resection (AS), orthodontic extrusion (OE), and surgical crown lengthening (SCL) in respect to RCRR, respectively.

Material and Methods

Human maxillary central incisors were endodontically treated, decoronated and divided into 4 groups (n = 48). Following specimen preparation was performed: (I) adhesive core-and-post build-up (control), (II) as (I) and 2mm apical root resection (AS), (III) before adhesive core-and-post build-up teeth were shortened 2mm coronally (OE) (IV) as (I), but specimens were embedded 4mm instead of 2mm below the CEJ (SCL), group (V) implant-borne restoration with individual all-ceramic abutments (n = 12; ∅4.1/l = 12mm) (IBR). All specimens received all-ceramic crowns, thermo-mechanical (TML), and subsequent linear loading (LL) until failure. RCRR were calculated and Log-rank, Kruskal-Wallis, Mann-Whitney-U, ANOVA, and Chi-Square tests applied (p = 0.05).

Results

Fracture loads after subsequent LL differed significantly (p = 0.001) between groups, while implants showed highest values. Fmax median (min/max): (I) 252 (204/542), (II) 293 (243/443), (III) 253 (183/371), (IV) 195 (140/274), (V) 446 (370/539). Pair-wise comparison showed significant differences (p = 0.001) between group I / IV and group V, I and IV (p = 0.045), II and IV (p = 0.001), and III compared to IV (p = 0.033), respectively. RCRR below 1 significantly increased load capability compared to RCRR =1.

Conclusions

OE appears to preferable to ensure biomechanical stability of severely damaged teeth compared to SCL. AR has no adverse biomechanical impact. RCRR < 1 is biomechanically beneficial.
Clinical Relevance: In case of a severely damaged maxillary incisor orthodontic extrusion should be preferred compared to surgical crown lengthening prior single-crown restoration. As orthodontic extrusion apical root resection has no adverse effect on load capability. Single-crown implant-borne restoration are most load capable.
Integrating Herbal Medicine into Oncology Care Delivery: Development, Implementation and Evaluation of a Novel Program
Authors: Hou Yen-Nien , Chimonas Susan , Gubili Jyothirmai , Deng Gary , Mao Jun
Published: October 2022

Objective
To develop, implement and evaluate a novel program facilitating patient-provider communication about, and appropriate use of, herbal medicine at a large academic cancer center.
Methods
In the Herbal Oncology Program (HOP), integrative medicine providers counseled patients about unmet symptom needs and prescribed traditional Chinese medicine (TCM) herbs when indicated, taking into consideration the clinical context, patient preference, and research evidence. Follow-ups assessed use and tracked outcomes. Medical record data included symptoms and other concerns that motivated patients to seek herbal products; types and numbers of dispensed TCM herbs; and demographic characteristics. A survey assessed patient experience and satisfaction.
Results
All 851 participants were outpatients, with 712 (84%) in active treatment. HOP dispensed 1266 herbal prescriptions for a range of symptoms, most commonly GI symptoms (467, 37%); pain (353, 28%); and treatment-related fatigue, sleep and mood disorders (346, 27%). Of 269 patients invited to the survey, 107 (40%) completed it. A majority 70.9% (73/103) were satisfied with the effectiveness of dispensed herbs in relieving their symptoms, and few 6.7% (7/104) had experienced mild adverse events that resolved after discontinuing herbal use.
Conclusions
HOP demonstrates the feasibility of integrating herbal medicine into an academic oncology setting. Patient satisfaction with HOP was high, with limited adverse events. The patterns of herbal prescriptions in HOP suggest future areas for clinical research to strengthen the evidence base around safe and effective use.
Automatic detection and vascular territory classification of hyperacute staged ischemic stroke on diffusion weighted image using convolutional neural networks
Authors: Lee Kun-Yu , Liu Chia-Chuan , Chen David Yen-Ting , Weng Chi-Lun , Chiu Hung-Wen , Chiang Chen-Hua
Published: October 2022

Purpose
Automated ischemic stroke detection and classification according to its vascular territory is an essential step in stroke image evaluation, especially at hyperacute stage where mechanical thrombectomy may improve patients’ outcome. This study aimed to evaluate the performance of various convolutional neural network (CNN) models on hyperacute staged diffusion-weighted images (DWI) for detection of ischemic stroke and classification into anterior circulation infarct (ACI), posterior circulation infarct (PCI) and normal image slices.
Materials and Methods
In this retrospective study, 253 cases of hyperacute staged DWI were identified, downloaded and reviewed. After exclusion, DWI from 127 cases were used and we created a dataset containing total of 2119 image slices, and separates it into three groups, namely ACI (618 slices), PCI (149 slices) and normal (1352 slices). Two transfer learning based CNN models, namely Inception-V3, EfficientNet-b0 and one self-derived modified LeNet model were used. The performance of the models was evaluated and activation maps using gradient-weighted class activation mapping (Grad-Cam) technique were made.
Results
Inception-V3 had the best overall accuracy (86.3%), weighted F1 score (86.2%) and kappa score (0.715), followed by modified LeNet (85.2% accuracy, 84.7% weighted F1 score and 0.693 kappa score). The EfficientNet-b0 had the poorest performance of 83.6% accuracy, 83% weighted F1 score and 0.662 kappa score. The activation map showed that one possible explanation for misclassification is due to susceptibility artifact.
Conclusions
A sufficiently high performance can be achieved by using CNN model to detect ischemic stroke on hyperacute staged DWI and classify it according to vascular territory.
On the characterization of bias errors in defocusing-based 3D particle tracking velocimetry for microfluidics
Authors: Coutinho Gonçalo , Moita Ana , Ribeiro Ana , Moreira António , Rossi Massimiliano
Published: October 2022

In this work, we provide a systematic theoretical and experimental characterization of bias errors in defocusing particle tracking (DPT) methods with respect to microfluidic applications. Bias errors are often neglected in DPT measurements and to date only few works reported empirical procedures to compensate for that. A generalized bias correction procedure as well as a systematic characterization of the impact of such error in DPT measurements is still lacking.We show that the field curvature aberration and the refractive index mismatch are the main sources of bias error in these applications. We propose a correction methodology based on the determination of the curved focal plane by means of a reference measurement of a Poiseuille flow.We discuss the impact of the refractive index mismatch and how to correctly compensate for it. We validated our methodology and quantified the bias errors on 10 different experimental setups, using different working fluids, materials, geometries, and microscope objective lenses ranging from 5 \(\times\) to 40$\times$ magnification. Our results indicate that the impact of this type of bias errors is in general not predictable and must be evaluated case by case. The proposed methodology allows to estimate and minimize the bias error in most microfluidic setups and is suitable for any single-camera DPT approach.
Effect of ICU quality control indicators on VAP incidence and mortality: a Retrospective Study of 1267 hospitals in China
Authors: Ding Xin , Ma Xudong , Gao Sifa , Su Longxiang , Shan Guangliang , Hu Yaoda , Chen Jieqin , Ma Dandan , Zhang Feng , Zhu Wen , Sun Guoqiang , Meng Xiaoyang , Ma Lian , Zhou Xiang , Liu Dawei , Du Bin
Published: October 2022

Purpose
To investigate the effects of ICU quality control indicators on the VAP morbidity and mortality in China throughout 2019
Methods
This was a retrospective study. A total of 1267 ICUs from 30 provinces in mainland China were included. Data were collected using the National Clinical Improvement System Data that reports ICU information. 10 related quality control indicators were analyzed, including 5 structural factors (patient-to-bed ratio, physician-to-bed ratio, nurse-to-bed ratio, patient-to-physician ratio, patient-to-nurse ratio), 3 process factors (unplanned endotracheal extubation rate, reintubation rate within 48h, and microbiology detection rate before antibiotic use) and 2 outcome factors (VAP morbidity and mortality). The information of most common infectious pathogens and most common used antibiotics in ICU was also collected. Generalized linear mixed models were used to analyze the association between these factors and VAP morbidity and mortality.
Results
The morbidity of VAP in these hospitals in 2019 was 5.03 (2.38, 10.25) per 1000 ventilator days, and the mortality of VAP was 11.11 (0.32, 26.00)%. The most common causative pathogen was Acinetobacter baumannii (in 39.98% hospitals), followed by Klebsiella pneumoniae (38.26%), Pseudomonas aeruginosa and Escherichia coli. In 26.90% hospitals, third-generation cephalosporin was the most used antibiotics, followed by carbapenem (24.22%), penicillin and beta-lactamase inhibitor combination (20.09%), cephalosporin with beta-lactamase inhibitor (17.93%). All the structural factors were significantly associated with VAP morbidity, but not with the mortality, although the trend was inconsistent. Process factors including unplanned endotracheal extubation rate, reintubation rate in 48 hours and microbiology detection rate before antibiotic use were associated with higher VAP mortality, while unplanned endotracheal extubation rate and reintubation rate in 48 hours were associated with higher VAP mortality. Furthermore, K. pneumoniae as the most common pathogen was associated with higher VAP mortality, and carbapenems as the most used antibiotics was associated with lower VAP mortality.
Conclusion
This study highlights the association between the ICU QC factors and VAP morbidity and mortality. The process factors rather than the structural factors need to be further improved for the QC of VAP in ICU.
The vessels around the transverse colon mesentery – An investigation using 44 cadaver specimens and 505 cases in which dynamic computed tomography angiography was performed
Authors: Ogi Yusuke , Egi Hiroyuki , Ishimaru Kei , Koga Shigehiro , Yoshida Motohira , Kikuchi Satoshi , Akita Satoshi , Sugishita Hiroki , Matsumoto Hironori , Shimokawa Tetsuya , Takeuchi Akihide , Watanabe Yuji
Published: October 2022

Background. Laparoscopic and robotic surgery for transverse colon cancer are difficult due to complex fusion of the foregut and midgut and variation of the vessels of the transverse colon. Although the vessels of the right colon have been investigated, middle colic artery (MCA) variation and the relationship with vessels around the transvers colon are unknown. We investigated variation of the MCA using computed tomography angiography (CTA) and cadaver specimen, and the relationship between the superior mesenteric vein (SMV) and MCA using CTA. The classification of vessels around the transverse colon may lead to safer and reliable surgery. Methods. This study included 505 consecutive patients who underwent CTA in our institution from 2014 to 2020 and 44 cadaver specimens. Vascular anatomical classifications and relationships were analyzed using CT images. Results. The MCA was defined as the arteries arising from the superior mesenteric artery (SMA) that flowed into the transverse colon at the distal ends. The classifications were as follows: Type I, branching right and left from common trunk; Type II, the right and left branches bifurcated separately from the SMA; and Type III, the MCA branched from a vessel other than the SMA. Type II was subclassified into two subtypes, Type IIa with one left branch and Type IIb with two or more left branches from SMA. In the CTA and cadaver studies, respectively, the classifications were as follows: type I, n = 290 and n = 31; type IIa, n = 211 and n = 13; type IIb, n = 3 and n = 0; and type III, n = 1 and n = 0. We classified the relationship between the MCA and left side of the SMV into three types: Type A, a common trunk runs along the left edge of the SMV (n = 173; 59.7%); Type B, a right branch of the MCA runs along the left edge of the SMV (n = 116; 40.0%); and type C, the MCA runs dorsal of the SMV (n = 1; 0.3%). Conclusions. This study revealed that The MCA branching classifications and relationship between the SMV and MCA. Preoperative CT angiography may be able to reliably identify vessel variation, which may be practically useful.
Comprehensive performance of a low-cost spring-assisted mechanism for digital light processing
Authors: Yang Cheng-Jung , Wu Sin-Syuan
Published: October 2022

In the field of additive layer manufacturing, constrained-surface digital light processing has attracted considerable attention due to its high precision and low material loss. During the process of separating the cured layer from the resin tank, the high separation force generated by the pulling-up mechanism increases the printing failure rate and reduces the life cycle of the resin tank. Although changing the separation mechanism can significantly reduce the separation force, this often has the tradeoff of high equipment costs. This study comprehensively evaluated the performance of a low-cost spring-assisted mechanism for the separation process. The Taguchi method was used to confirm the variability of the spring-assisted mechanism and obtain the parameters that minimize the separation force and time. The spring-assisted mechanism was then applied to printing different geometric shapes and areas, and the results demonstrated better manufacturing stability than the pulling-up or tilting mechanism. A linear regression equation was established to predict the separation force of specific geometric shapes and areas to greatly reduce the calculation costs and time.
Accuracy of a noninvasive estimated continuous cardiac output measurement under different respiratory conditions: a prospective observational study
Authors: Takakura Masashi , Fujii Tasuku , Taniguchi Tomoya , Suzuki Shogo , Nishiwaki Kimitoshi
Published: October 2022

Purpose

Recently, the estimated continuous cardiac output (esCCO) system was developed as a noninvasive hemodynamic monitoring alternative to thermodilution cardiac output (TDCO). However, the accuracy of CCO measurements by the esCCO compared with TDCO under different respiratory conditions remains unclear. This prospective study aimed to assess the clinical accuracy of the esCCO by continuously measuring the esCCO and TDCO.

Methods

This study enrolled 40 patients who had undergone cardiac surgery with pulmonary artery catheterization. We compared the esCCO with TDCO from mechanical ventilation to spontaneous respiration through extubation. Patients undergoing cardiac pacing during the esCCO measurement, those receiving treatment with an intra-aortic balloon pump, and those with measurement errors or missing data were excluded. On the basis of these criteria, 23 patients were included. Agreement between the esCCO and TDCO was evaluated using Bland–Altman analysis with a 20-minute moving average of the esCCO.

Results

The paired esCCO and TDCO measurements (939 points before extubation and 1112 points after extubation) were compared. The respective bias and standard deviation (SD) values were 0.13 L/min and 0.60 L/min before extubation and − 0.48 L/min and 0.78 L/min after extubation. There was a significant difference in bias before and after extubation (P < 0.001); the SD before and after extubation was not significant (P = 0.315). The percentage errors were 25.1% before extubation and 29.6% after extubation, which is the criterion for acceptance of a new technique.

Conclusion

The accuracy of esCCO measurement is clinically acceptable to that of TDCO under mechanical ventilation and spontaneous respiration.
This study was registered with the UMIN Clinical Trials Registry on September 1st, 2021 (identifier: UMIN000044712).