bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Study of Traditional Village Renewal Characteristics Driven by Different Entities from the Perspective of Place-Making
Authors: Liu Naifei , Zhang Huinan
Published: May 2024

The renewal of traditional villages should not only focus on the protection of cultural heritage but also comprehensively consider the development of social, economic, and environmental aspects. The concept of place-making offers an effective strategy to address the issues faced by traditional villages today, such as the destruction of cultural heritage, socioeconomic decline, and population loss. At the core of place-making is the establishment of harmonious human–land relationships. This study aims to explore the influence of different entities on place-making during the process of traditional village renewal. This research focused on traditional villages in southeastern China. Based on literature reviews and field surveys, this study employed the analytic hierarchy process (AHP) to develop evaluation criteria for traditional village renewal based on place-making. By selecting case studies of traditional village renewal driven by three entities, government, artists, and villagers, relevant data were collected through field surveys and expert assessments, followed by a comparative analysis of these villages using the place-making evaluation criteria. The results indicate significant differences in traditional village renewal due to varying entity-driven approaches, leading to diverse impacts on different facets of place-making. In conclusion, establishing a renewal model for traditional villages that involves diverse entities is crucial for achieving comprehensive place-making and ensuring the high-quality, integrated, and sustainable development of traditional villages.
Analysis and Enlightenment on the Relationships between Two Kinds of Cutter Life Evaluation Indexes and Installation Radius: A Case Study
Authors: Liu Jianping , He Tiankui , Zhou Zhijia , Peng Xingxin , Pan Yucong
Published: May 2024

Accurate evaluation of cutter life at different cutter positions on the cutter head is helpful to determine the time of cutter change and reduce the time of cutter wear measurement, which is of great significance to improve the tunneling efficiency of tunnel boring machine (TBM) projects. Unfortunately, there is no unified cutter life evaluation index now. The field data of cutter wear are collected from a section of a long TBM tunneling water conveyance tunnel in China. Two kinds of cutter life evaluation indexes (based on the radial wear extent of cutter rings and replacement number of cutter rings) are selected and the variation rule between these two kinds of indexes with cutter installation radius is statistically analyzed. The results show that the regression relationships between the two kinds of cutter life evaluation indexes and installation radius mainly present linear functions and quadratic functions. Those regression relationships are affected by factors such as wear type, installation angle, cutter spacing, influence width, and allowable limit wear extent of cutter rings. Considering the calculation accuracy of the evaluation index, the actual working conditions of the disc cutter, and ignoring the influence of tunnel diameter, it is recommended to preferentially choose the radial wear extent of cutter rings per unit rolling distance as the evaluation index of cutter life. The research results can provide a reference for the selection of cutter life evaluation index, prediction of disc cutter life at different cutter positions, and establishment of cutter life prediction mode.
Renovation Analysis of a Socialist Modernism Office Building–Case Study
Authors: Sylejmani Arta , Milovanović Bojan , Banjad Pečur Ivana , Nushi Violeta
Published: May 2024

Socialist modernist architecture in the Balkan has left a valuable legacy of remarkable buildings from this century, which brought a mixture of new experiences and local traditions. Unfortunately, after the 1990s, many of these buildings have been neglected, improperly treated, or abandoned. This paper focuses on the iconic socialist modernist office building “Rilindja” in Prishtina, Kosovo, which was built in 1979. In 2010, the building envelope was changed in the name of revitalization, without considering the energy aspect. The study aims to present energy performance analysis through cost-optimal renovation measures of the building envelope while restoring the architectural values before the last renovation. Using Archicad and EcoDesigner STAR, a BIM model was created, and energy analysis was conducted. The findings indicate that eighteen proposed energy efficiency measures can achieve a reduction in energy consumption for heating and cooling of more than 80% over the life cycle period of 20 years. The comparison before and after renovation considering restoring and preserving the inherent values, while integrating energy efficiency measures was necessary, as there is a lack of such studies in the general literature. Finally, the potential of restoring the collective memory through cost-optimal analysis is emphasized as an approach for similar cases.
Prospective, Observational Study of Aflibercept Use in Combination with FOLFIRI in Patients with Metastatic Colorectal Cancer: A Real-World Effectiveness Study
Authors: Durbajło Agnieszka , Świeżyński Marcin , Ziemba Beata , Starzyczny-Słota Danuta , Samborska-Plewicka Marzena , Cencelewicz-Lesikow Anna , Chrzanowska-Kapica Agata , Dobrzyńska-Rutkowska Aneta , Drab-Mazur Iwona , Kulma-Kreft Monika , Sikora-Skrabaka Magdalena , Matuszewska Elwira , Foszczyńska-Kłoda Małgorzata , Lewandowski Tomasz , Słomian Grzegorz , Ostrowska-Cichocka Krystyna , Chmielowska Ewa , Wiśniowski Rafał , Twardosz Anna , Wierzbicka Katarzyna , Rumianowski Leszek , Wyrwicz Lucjan
Published: May 2024

Background: This was an observational study prospectively evaluating the effectiveness and safety of aflibercept/FOLFIRI administered in second-line mCRC per the reimbursement criteria in Poland. Methods: Consecutive mCRC patients who progressed with first-line oxaliplatin-based chemotherapy received aflibercept (4 mg/kg IV) followed by FOLFIRI every 2 weeks until progression or unacceptable toxicity. The primary endpoint was progression-free survival (PFS); overall survival (OS) and safety were the secondary endpoints. Results: A total of 93 patients were treated at 17 Polish sites. A median of 10 cycles was administered. Over a median treatment duration of 5.3 months, median PFS and median OS were 8.4 months [95% CI, 6.9–9.9] and 27.0 months [95% CI, 23.9–30.1], respectively. There was no significant impact of primary tumor location, metastatic site, or KRAS status on PFS and OS. Main grade ≥ 3 adverse events were neutropenia (16%), hypertension (8%), diarrhea (4%), and stomatitis (4%). Conclusions: The benefits/risks of Aflibercept plus FOLFIRI administered per the Polish reimbursement criteria in second-line treatment of mCRC after failure of a prior oxaliplatin-based regimen is confirmed.
Helium Ion Therapy for Advanced Juvenile Nasopharyngeal Angiofibroma
Authors: Hoeltgen Line , Meixner Eva , Hoegen-Saßmannshausen Philipp , Kim Ji-Young , Deng Maximilian , Seidensaal Katharina , Held Thomas , Herfarth Klaus , Haberer Thomas , Debus Jürgen , Mairani Andrea , Harrabi Semi , Tessonnier Thomas
Published: May 2024

Helium ion therapy (HRT) is a promising modality for the treatment of pediatric tumors and those located close to critical structures due to the favorable biophysical properties of helium ions. This in silico study aimed to explore the potential benefits of HRT in advanced juvenile nasopharyngeal angiofibroma (JNA) compared to proton therapy (PRT). We assessed 11 consecutive patients previously treated with PRT for JNA in a definitive or postoperative setting with a relative biological effectiveness (RBE) weighted dose of 45 Gy (RBE) in 25 fractions at the Heidelberg Ion-Beam Therapy Center. HRT plans were designed retrospectively for dosimetric comparisons and risk assessments of radiation-induced complications. HRT led to enhanced target coverage in all patients, along with sparing of critical organs at risk, including a reduction in the brain integral dose by approximately 27%. In terms of estimated risks of radiation-induced complications, HRT led to a reduction in ocular toxicity, cataract development, xerostomia, tinnitus, alopecia and delayed recall. Similarly, HRT led to reduced estimated risks of radiation-induced secondary neoplasms, with a mean excess absolute risk reduction of approximately 30% for secondary CNS malignancies. HRT is a promising modality for advanced JNA, with the potential for enhanced sparing of healthy tissue and thus reduced radiation-induced acute and long-term complications.
Correction: Liu et al. Current Understanding of Microbiomes in Cancer Metastasis. Cancers 2023, 15, 1893
Authors: Liu Jiaqi , Luo Feiyang , Wen Liyan , Zhao Zhanyi , Sun Haitao
Published: May 2024

In the original publication [...]
Evaluation of ARID1A as a Potential Biomarker for Predicting Response to Immune Checkpoint Inhibitors in Patients with Endometrial Cancer
Authors: Yamashita Hitomi , Nakayama Kentaro , Kanno Kosuke , Ishibashi Tomoka , Ishikawa Masako , Iida Kouji , Razia Sultana , Kiyono Tohru , Kyo Satoru
Published: May 2024

Background: AT-rich interaction domain 1A (ARID1A) has been proposed as a new biomarker for predicting response to immune checkpoint inhibitors (ICIs). The predictive value of ARID1A for predicting ICI effectiveness has not been reported for endometrial cancer. Therefore, we investigated whether ARID1A negativity predicts ICI effectiveness for endometrial cancer treatment. Methods: We evaluated ARID1A expression, tumor-infiltrating lymphocytes (CD8+), and immune checkpoint molecules (PD-L1/PD-1) by immunostaining endometrial samples from patients with endometrial cancer. Samples in which any of the four mismatch repair proteins (MLH1, MSH2, MSH6, and PMS2) were determined to be negative via immunostaining were excluded. In the ARID1A-negative group, microsatellite instability (MSI) status was confirmed via MSI analysis. Results: Of the 102 samples investigated, 25 (24.5%) were ARID1A-negative. CD8 and PD-1 expression did not differ significantly between the ARID1A-negative group and the ARID1A-positive group; however, the ARID1A-negative group showed significantly lower PD-L1 expression. Only three samples (14.2%) in the ARID1A-negative group showed high MSI. Sanger sequencing detected three cases of pathological mutation in the MSH2-binding regions. We also established an ARID1A-knockout human ovarian endometriotic epithelial cell line (HMOsisEC7 ARID1A KO), which remained microsatellite-stable after passage. Conclusion: ARID1A negativity is not suitable as a biomarker for ICI effectiveness in treating endometrial cancer.
Cribriform versus Intraductal: How to Determine the Difference
Authors: Compérat Eva , Kläger Johannes , Rioux-Leclercq Nathalie , Oszwald André , Wasinger Gabriel
Published: May 2024

Over the years, our understanding of cribriform and intraductal prostate cancer (PCa) has evolved significantly, leading to substantial changes in their classification and clinical management. This review discusses the histopathological disparities between intraductal and cribriform PCa from a diagnostic perspective, aiming to aid pathologists in achieving accurate diagnoses. Furthermore, it discusses the ongoing debate surrounding the different recommendations between ISUP and GUPS, which pose challenges for practicing pathologists and complicates consensus among them. Recent studies have shown promising results in integrating these pathological features into clinical decision-making tools, improving predictions of PCa recurrence, cancer spread, and mortality. Future research efforts should focus on further unraveling the biological backgrounds of these entities and their implications for clinical management to ultimately improve PCa patient outcomes.
Comparative Assessment of the Anti-Helicobacter pylori Activity and Gastroprotective Effects of Three Herbal Formulas for Functional Dyspepsia In Vitro
Authors: Wang Jing-Hua , Han Song-Yi , Kim Jisuk , Lim Sookyoung , Jeong Chaehee , Wu Liangliang , Kim Hojun
Published: May 2024

Helicobacter pylori has been implicated in various gastrointestinal disorders, including functional dyspepsia. This study aimed to compare the anti-H. pylori activity and gastroprotective effects of three typical herbal formulas used for gastrointestinal disorders in Korea: Shihosogan-tang (ST), Yijung-tang (YT), and Pyeongwi-san (PS). Firstly, we assessed the total phenolic and flavonoid contents, as well as the antioxidative capacity. Additionally, we evaluated the antibacterial effect on H. pylori using an ammonia assay, minimum inhibitory concentration (MIC) test, and the disk agar diffusion method. Furthermore, we examined alterations in the gene expression of tight junction proteins, pro-inflammatory cytokines, and cellular vacuolation using an AGS cell model infected with H. pylori. While ST exhibited a higher total phenolic content, superior free radical scavenging, and inhibition of H. pylori compared to YT and PS, YT more evidently inhibited gastric cellular morphological changes such as vacuolation. All formulations significantly ameliorated changes in inflammatory and gastric inflammation-related genes and cellular morphological alterations induced by H. pylori infection. Overall, the present in vitro study suggests that all three herbal formulas possess potential for ameliorating gastrointestinal disorders, with ST relatively excelling in inhibiting H. pylori infection and inflammation, while YT potentially shows greater efficacy in directly protecting the gastric mucosa.
Synergistic Effect of Co and Ni Co-Existence on Catalytic Decomposition of Ammonia to Hydrogen—Effect of Catalytic Support and Mg-Al Oxide Matrix
Authors: Kowalczyk Andrzej , Rutkowska Małgorzata , Gnyla Sylwia , Pacia Michał , Chmielarz Lucjan
Published: May 2024

Hydrotalcite-derived mixed metal oxides containing Co and Ni and containing these metals supported on MgO and Al2O3 were prepared and tested as catalysts for the decomposition of ammonia to hydrogen and nitrogen. The obtained samples were characterised in terms of chemical composition (ICP-OES), structure (XRD), textural parameters (low-temperature N2 adsorption–desorption, SEM), form and aggregation of transition-metal species (UV-Vis DRS), reducibility (H2-TPR) and surface acidity (NH3-TPD). The catalytic efficiency of the tested systems strongly depends on the support used. Generally, the alumina-based catalyst operated at lower temperatures compared to transition metals deposited on MgO. For both series of catalysts, a synergistic effect of the co-existence of cobalt and nickel on the catalytic efficiency was observed. The best catalytic results were obtained for hydrotalcite-derived catalysts; however, in the case of these catalysts, an increase in the Al/Mg ratio resulted in a further increase in catalytic activity in the decomposition of ammonia.
Home Anxiety Assessment and Influencing Factors among Adolescent Athletes in Yantai City
Authors: Chen Yuxi , Ye Chunming , Lin Yang , Ma Yongjie , Zhang Xingyu , Wang Jiu
Published: May 2024

Objective: To understand the prevalence of home-related anxiety among adolescent athletes during the novel coronavirus pandemic and to ascertain the factors influencing this anxiety. Methods: We employed cluster sampling to select 1150 adolescent athletes (aged 8–18 years) from six sports training schools in Yantai City, Shandong Province. Mental health status was assessed and recorded. Chi-square tests and multivariable logistic regression were used to analyze the factors contributing to athletes’ anxiety. Results: The survey revealed a COVID-19 infection rate of 38.23% (437 individuals) with an anxiety score of 40.98 ± 8.20 and an anxiety detection rate of 11.29% (129 individuals) during the COVID-19 epidemic. Female athletes exhibited a higher anxiety rate of 14.40% compared to 8.40% in male athletes. Multivariate analysis identified female gender as a risk factor for anxiety (OR = 1.64), while participation in aquatics emerged as a protective factor (OR = 0.24, 95% CI: 1.08–2.48). Professional training duration exceeding three years increased anxiety risk (OR = 3.05, 95% CI: 1.67–5.58), as did not seeking help during difficulties (OR = 2.59, 95% CI: 1.33–5.01). Interestingly, parental care was linked to increased anxiety risk (OR = 2.44, 95% CI 1.34–4.44), while care from friends was protective (OR = 0.60, 95% CI: 0.36–1.01), which was possibly due to the pressure associated with parental expectations. Conclusions: Adolescent athletes, particularly females and those with extended training durations, exhibit a heightened susceptibility to anxiety. This study also highlights that athletes who proactively seek assistance during challenging situations tend to experience lower anxiety levels. Additionally, a lack of COVID-19 infection and the involvement of concerned parents contribute to reduced anxiety among these young athletes.
The Relationship between Physical Activity and Motor Competence of Foundation Phase Children in Wales during the School Day
Authors: John Amanda , Wainwright Nalda , Goodway Jacqueline D. , Williams Andy
Published: May 2024

Early childhood is a crucial time for children to develop their fundamental motor skills (FMS), serving as a foundation for engagement in lifelong physical activity (PA). With increasing concerns over the declining levels of PA and motor competence (MC), the aim of this study was to explore the predictors of PA in children in a play-based curriculum. A secondary purpose was to explore levels of PA and MC during the school day. The final aim was to explore whether there were sex differences. Children (N = 94; Mage = 68.96 months, SD = 8.25) in five classes from four different schools in Wales were tested on the TGMD-2, standing long jump, and MABC-2. Levels of PA were measured using ActiGraph GT3X-BT accelerometers, and 85 children met the wear time criteria. Object control (OC) skills, standing long jump, and age significantly predicted the percentage of time spent performing sedentary behaviours F(10,73) = 3.026, p = 0.003, R2 = 0.29 (adj R2 = 0.20) and time spent on MVPA F(10,73) = 3.597, p < 0.001, R2 = 0.33 (adj R2 = 0.24). Children spent an average of 48.7% of the school day performing sedentary behaviours and 9.1% performing moderate to vigorous physical activity (MVPA) and did not achieve 60 min of MVPA. The MABC revealed that 67% were below the 15th percentile. Girls spent more time than boys performing sedentary behaviours (p = 0.014), and boys spent more time than girls on MVPA (p = 0.004). Boys outperformed girls at OC skills (p < 0.001), while girls outperformed boys at locomotor skills (p < 0.001). These findings reinforce the pivotal role teachers and parents play in providing opportunities for children to be PA. OC skills and jump were positively associated with PA, emphasising the importance of developing FMS in early childhood. There were also sex disparities for both PA and MC, along with low levels of MC, highlighting the need for investing in comprehensive programmes and initiatives that prioritise the development of FMS during early childhood.
Sex Differences in Children with Uncomplicated Attention Deficit/Hyperactivity Disorder and Sleep Problems
Authors: Lindholm Annelie , Jarbin Håkan , Aili Katarina , Nygren Jens M. , Svedberg Petra , Larsson Ingrid
Published: May 2024

Background: Approximately 7.6% of children are diagnosed with attention deficit/hyperactivity disorder (ADHD), and sleep impairments affect 25–85%. There is a noticeable lack of research on girls and sex differences. The aim of this study was to examine sex differences in children with uncomplicated ADHD and sleep problems. Methods: Cross-sectional baseline data were retrieved from a randomized controlled trial with weighted blankets (55 boys and 41 girls, 6–14 years) on a cohort recently diagnosed with uncomplicated ADHD and sleep problems. Differences between boys and girls in ADHD symptoms, objectively and subjectively measured sleep, anxiety, and functioning were examined via parent- or self-reported validated instruments. Results: Girls reported significantly lower (worse) satisfaction with well-being, life overall, and school, but not for family. Parents reported more sleep anxiety and night-time wakings among boys, but no sex differences in other measures and also not in self-reported measures or objective sleep measures. Children who reported worry, sadness, or unhappiness had more sleep problems. Conclusions: Boys with ADHD and sleep problems may need support with sleep-related anxiety and night-time wakings, while girls may require support with overall functioning. Additionally, children who express feelings of worry, sadness, or unhappiness alongside their ADHD symptoms should have attention given to their sleep.
Combining RNAscope, Immunohistochemistry (IHC) and Digital Image Analysis to Assess Podoplanin (PDPN) Protein and PDPN_mRNA Expression on Formalin-Fixed Paraffin-Embedded Normal Human Placenta Tissues
Authors: Tomescu Larisa Cristina , Cosma Andrei Alexandru , Fenesan Mihaela Pasca , Melnic Eugen , Petrovici Vergil , Sarb Simona , Chis Monica , Sas Ioan , Ribatti Domenico , Cimpean Anca Maria , Dorobantu Florica Ramona
Published: May 2024

The expression and function of podoplanin (PDPN) in the normal human placenta has been debated in placental evaluation. This study emphasizes the importance of a multimodal approach of PDPN expression in normal human placentas. A complete examination is performed using immunohistochemistry, RNAscope and automated Digital Image examination (DIA) interpretation. QuPath DIA-based analysis automatically generated the stromal and histological scores of PDPN expression for immunohistochemistry and RNAscope stains. The umbilical cord’s isolated fibroblasts and luminal structures expressed PDPN protein and PDPN_mRNA. RNAscope detected PDPN_mRNA upregulation in syncytial placental knots trophoblastic cells, but immunohistochemistry did not certify this at the protein level. The study found a significant correlation between the IHC and RNAscope H-Score (p = 0.033) and Allred Score (p = 0.05). A successful multimodal strategy for PDPN assessment in human placentas confirmed PDPN expression heterogeneity in the full-term human normal placenta and umbilical cord at the protein and mRNA level. In placental syncytial knots trophoblastic cells, PDPN showed mRNA overexpression, suggesting a potential role in placenta maturation.
Soil and Mineral Nutrients in Plant Health: A Prospective Study of Iron and Phosphorus in the Growth and Development of Plants
Authors: Bhat Mujtaba Aamir , Mishra Awdhesh Kumar , Shah Sheezma Nazir , Bhat Mudasir Ahmad , Jan Saima , Rahman Safikur , Baek Kwang-Hyun , Jan Arif Tasleem
Published: May 2024

Plants being sessile are exposed to different environmental challenges and consequent stresses associated with them. With the prerequisite of minerals for growth and development, they coordinate their mobilization from the soil through their roots. Phosphorus (P) and iron (Fe) are macro- and micronutrient; P serves as an important component of biological macromolecules, besides driving major cellular processes, including photosynthesis and respiration, and Fe performs the function as a cofactor for enzymes of vital metabolic pathways. These minerals help in maintaining plant vigor via alterations in the pH, nutrient content, release of exudates at the root surface, changing dynamics of root microbial population, and modulation of the activity of redox enzymes. Despite this, their low solubility and relative immobilization in soil make them inaccessible for utilization by plants. Moreover, plants have evolved distinct mechanisms to cope with these stresses and coregulate the levels of minerals (Fe, P, etc.) toward the maintenance of homeostasis. The present study aims at examining the uptake mechanisms of Fe and P, and their translocation, storage, and role in executing different cellular processes in plants. It also summarizes the toxicological aspects of these minerals in terms of their effects on germination, nutrient uptake, plant–water relationship, and overall yield. Considered as an important and indispensable component of sustainable agriculture, a separate section covers the current knowledge on the cross-talk between Fe and P and integrates complete and balanced information of their effect on plant hormone levels.
Atomic Layer Deposition Growth and Characterization of Al2O3 Layers on Cu-Supported CVD Graphene
Authors: Rafailov Peter , Mehandzhiev Vladimir , Sveshtarov Peter , Blagoev Blagoy , Terziyska Penka , Avramova Ivalina , Kirilov Kiril , Ranguelov Bogdan , Avdeev Georgi , Petrov Stefan , Lin Shiuan Huei
Published: May 2024

The deposition of thin uniform dielectric layers on graphene is important for its successful integration into electronic devices. We report on the atomic layer deposition (ALD) of Al2O3 nanofilms onto graphene grown by chemical vapor deposition onto copper foil. A pretreatment with deionized water (DI H2O) for graphene functionalization was carried out, and, subsequently, trimethylaluminum and DI H2O were used as precursors for the Al2O3 deposition process. The proper temperature regime for this process was adjusted by means of the ALD temperature window for Al2O3 deposition onto a Si substrate. The obtained Al2O3/graphene heterostructures were characterized by Raman and X-ray photoelectron spectroscopy, ellipsometry and atomic force and scanning electron microscopy. Samples of these heterostructures were transferred onto glass substrates by standard methods, with the Al2O3 coating serving as a protective layer during the transfer. Raman monitoring at every stage of the sample preparation and after the transfer enabled us to characterize the influence of the Al2O3 coating on the graphene film.
Effect of Polytetrafluoroethylene Coating on Corrosion Wear Properties of AZ31 Magnesium Alloy by Electrophoretic Deposition
Authors: Zhang Jilun , Chen Chaoyi , Li Junqi , Chen Li
Published: May 2024

In this study, we aim to enhance the corrosion and wear resistance of AZ31 magnesium alloy using electrophoretic deposition (EPD) technology to apply a hydrophobic polytetrafluoroethylene (PTFE) coating. Polyethyleneimine (PEI) serves as a charged dispersant, facilitating uniform deposition of PTFE particles on the alloy surface. Results demonstrate a significant reduction in corrosion current density (from 67.5 μA/cm2 to 5.2 μA/cm2) and improved wear resistance (wear volume decreased from 0.24167 mm3 to 0.00167 mm3) in a 3.5 wt% NaCl solution compared to uncoated alloy. Moreover, the friction coefficient of the coated sample decreases. These findings underscore the potential of nano-PTFE coatings prepared via EPD in enhancing AZ31 magnesium alloy’s corrosion and wear resistance, providing a foundation for future protective coating design and optimization.
Effect of Thickness on the Residual Stress Profile of an Aluminum Cold Spray Coating by Finite Element Analysis
Authors: Torres Felipe , Fernandez Ruben
Published: May 2024

This research investigates the influence of thickness on residual stress profiles in aluminum cold spray coatings using finite element analysis (FEA). Residual stress is a critical factor that impacts coating adhesion, fatigue life, and susceptibility to delamination in thermal spray processes. Despite its acknowledged importance, predictive analysis of these stresses on a layer-by-layer basis remains relatively unexplored. This study introduces an innovative numerical methodology to analyze the progression of residual stresses across various deposition efficiencies (10%, 40%, 60%, and 100%) and layer thicknesses, thereby enhancing predictive accuracy for cold spray coatings. The findings demonstrate that the number of deposited layers significantly affects residual stress profiles in both coatings and the substrate, with compressive residual stress predominating in the coatings and deeper tensile stress predominating in the substrate. Residual stress behavior near the last deposited layer aligns with the expected peening effect. Discrepancies in substrate stress distributions may arise from variations in deposition parameters and unconsidered temperature effects. While the model generally aligns with theoretical and some empirical data, observed discrepancies underscore the need for further validation. This study lays the groundwork for informed decision-making for cold spray processes by providing insights into stress management, thereby contributing to enhancing coating integrity and performance.
Effect of Glazing Protocol on the Surface Roughness and Optical Properties of Lithia-Based Glass-Ceramics
Authors: Dal Piva Amanda Maria de Oliveira , van Leeuwen Nina Storm , da Rosa Lucas Saldanha , Kleverlaan Cornelis Johannes , Tribst João Paulo Mendes
Published: May 2024

Background: New lithia-based glass–ceramics, including Advanced Lithium Disilicate (ALD), have become popular in dentistry. However, it is unclear if glazing protocols for ALD might compromise its surface or optical properties. Thus, evaluating color and translucency changes in ALD and traditional lithium disilicate (LD) is crucial. Methods: This study aimed to assess how different firing protocols affect the surface and optical properties of LD and ALD. Sixty disc-shaped specimens were prepared, divided into three subgroups based on firing protocols, and subjected to surface roughness analysis. Specimens were immersed in coffee, wine, and water for 7 days, and then brushed. Color and translucency were measured. Results: Firing protocols significantly influenced surface roughness in LD (0.09–1.39 µm) and ALD (0.05–0.88 µm). Color differences were observed in both LD and ALD after 7 days, with visible changes within clinically acceptable thresholds. Translucency remained stable across firing protocols and staining liquids. Conclusions: Varying firing protocols impact surface roughness and color stability in LD and ALD. Despite differences, color and translucency changes remained within acceptable clinical thresholds, suggesting both materials are suitable for dental applications. Therefore, this study reinforces the reliability and versatility of these materials in restorative dentistry.
Computational Medical Image Analysis: A Preface
Authors: Sen Anando
Published: May 2024

There has been immense progress in medical image analysis over the past decade [...]
Crystal Structures, Molecular Docking and In Vitro Investigations of Two 4-Substituted 2-(5,5-dimethyl-3-styrylcyclohex-2-enylidene)malononitrile Derivatives as Potential Topoisomerase II Inhibitors
Authors: Peeva Martina , Georgieva Maya , Balacheva Aneliya , Ponticelli Maria , Bogdanov Ivan , Kolev Tsonko , Milella Luigi , Stammler Hans-Georg , Tzvetkov Nikolay
Published: May 2024

Type II topoisomerases (TOP2s) play a key role in altering the DNA topology by transiently cleaving both strands of a DNA duplex. Therefore, increased TOP2 activity is associated with many cancers. Herein, we present the synthesis, structural characterization, virtual screening, and structural exploration, as well as evaluation of the antiproliferative effects of two new 4-substituted 2-(5,5-dimethyl-3-styrylcyclohex-2-enylidene)malononitrile derivatives with potential application in the drug design of isoform-specific TOP2 inhibitors. Both compounds 1 and 2 were verified by ESI-TOF-MS, NMR, and single-crystal X-ray diffraction (SCXRD) analysis. Furthermore, we applied our recently proposed SCXRD/HYdrogen DEsolvation (HYDE) technology platform in order to perform molecular modeling, virtual screening, and structural exploration with 1 and 2. For this purpose, we used the crystal structure of human TOP2β complexed to DNA and the anticancer drug etoposide. Moreover, we further evaluated the antiproliferative activity of 1 and 2 on human hepatocarcinoma HepG2 cells and compared the observed effects with those of the reference hTOP2β inhibitor etoposide. Based on the obtained results, compounds 1 and 2 showed a virtually higher binding affinity (Ki HYDE values) over etoposide towards hTOP2β but lower antiproliferative activity compared to those of etoposide.
Crystal Growth and Spectroscopy of Yb2+-Doped CsI Single Crystal
Authors: Sofich Dmitriy , Myasnikova Alexandra , Bogdanov Alexander , Pankratova Viktorija , Pankratov Vladimir , Kaneva Ekaterina , Shendrik Roman
Published: May 2024

The single crystals of CsI-Yb2+ were grown, and their spectroscopic studies were conducted. The observed luminescence in CsI-Yb2+ is due to 5d–4f transitions in Yb2+ ions. Using time-resolved spectroscopy, spin-allowed and spin-forbidden radiative transitions of ytterbium ions at room temperature were found. The excitation spectra of Yb2+ luminescence bands were obtained in the range of 3–45 eV. The mechanism of charge compensation of Yb2+ ions in a CsI crystal was also studied, the spectrum of the thermally stimulated depolarization current was measured, and the activation energies of the two observed peaks were calculated. These peaks belong to impurity–vacancy complexes in two different positions. The charge compensation of Yb2+ occurs via cation vacancies in the nearest-neighbor and next-nearest-neighbor positions.The Yb2+ ions are promising dopants for CsI scintillators and X-ray phosphors in combination with SiPM photodetectors.
Spatio-Temporal Dynamics of Larval Fish Assemblage in the Nakdong River Estuary, South Korea
Authors: Choi Hee-Chan , Youn Seok-Hyun , Kim Sangil , Park Joo Myun
Published: May 2024

Estuaries are crucial fish nursery habitats owing to their high productivity and the presence of various microhabitats for the early development of aquatic organisms. This study investigated the temporal and spatial patterns of the species composition and abundance of larval fish assemblages in the Nakdong River estuary, South Korea, through bi-monthly sampling in the inner and outer estuaries. Fifty-five larval taxa were collected, and the larval fish assemblages were dominated by a few species. Engraulis japonicus (28.8%) was the most abundant, followed by Gobiidae sp.1 (22.6%), Clupea pallasii (13.9%), and Omobranchus sp. (6.1%). The species richness, abundance, and diversity tended to be higher during the warm season in the inner estuary. Multivariate analyses revealed that the structures of larval fish assemblages were significantly influenced by the season and site. Spatial and seasonal changes in larval fish assemblages resulted from the different occurrence patterns of common fish larvae in relation to water temperature and salinity. Among the predominant fish larvae, E. japonicus was captured more frequently in more saline outer estuaries during the warm season, whereas Gobiidae sp.1 and C. pallasii were more abundant in less saline inner estuaries during the warm and cold seasons, respectively. The results of this study improve our understanding of larval biodiversity in estuarine habitats in relation to environmental modification and contribute to the evaluation of nursery functions in the Nakdong River estuary.
Wernicke Encephalopathy Caused by Avoidance-Restrictive Food Intake Disorder in a Child: A Case-Based Review
Authors: Turrini Ida , Guidetti Clotilde , Contaldo Ilaria , Pulitanò Silvia , Rigante Donato , Veredice Chiara
Published: May 2024

Background: Wernicke encephalopathy (WE) is an acute and potentially fatal neuropsychiatric disorder resulting from thiamine deficiency: its etiology and clinical presentation can be heterogeneous and arduously recognized, especially in children and adolescents. Case presentation: An 8-year-old girl arrived to the emergency room with ataxic gait, nystagmus, and mental confusion after a 10-day history of repeated severe vomiting; her recent clinical history was characterized by restricted nutrition due to a choking phobia, which caused substantial weight loss. Brain magnetic resonance imaging revealed a bilaterally increased T2 signal in the medial areas of the thalami and cerebral periaqueductal region. Diagnosis of WE based on clinical and neuroradiological findings was established and confirmed after labwork showing low serum thiamine. Following psychiatric evaluation, the patient was also diagnosed with avoidance-restrictive food intake disorder (ARFID), which required starting cognitive behavioral therapy and introducing aripiprazole. The patient displayed improvement of the radiological findings after one month and complete resolution of her neurological symptoms and signs. Conclusions: Eating disorders like ARFID might forerun acute signs of WE; this possibility should be considered even in pediatric patients, especially when atypical neurological pictures or feeding issues come out.
Can a Novel Device with Pure Dry Air Increase the Shear Bond Strength of Dental Composites to Dentin? An Experimental Study
Authors: Kharma Khalil , Hardan Louis , Kassis Cynthia , Dimitriu Bogdan , Harouny Ryan , Baba Nadim Z. , Bourgi Rim , Zogheib Carina Mehanna
Published: May 2024

Modern conservative dentistry is taking the lead in daily clinical practice and is relying on adhesion. Whether it is a simple composite, ceramic inlays, onlays, veneers or crowns, the common factor for a successful outcome is a good bonding of these elements to dental structures. Thus, the purpose of this study was to evaluate the bond strength of resin composite to dentin when using a new device, the DENTIPURE KM™ (KM, Beirut, Lebanon), which provides a pure air flow, free of any contaminants and without humidity, when compared to other dental equipment. One hundred and eighty extracted human molars were equally divided into three groups according to the device used, the DENTIPURE KM™ (KM, Beirut, Lebanon), the KAVO™ (ESTETICA E30/E70/E80 Vision, KAVO, Biberach, Germany), or the ADEC™ (A-dec Performer 200, Newberg, OR, USA). The shear bond strength (SBS) was evaluated after 24 h of storage in distilled water on a universal testing machine. Statistical analysis was set with a level of significance at p ≤ 0.05. The results revealed that significantly different bond strength was imparted by the DENTIPURE KM™ device and the ADEC™ dental unit (p = 0.042). In conclusion, while the DENTIPURE KM™ device shows promise in providing contaminant-free air during bonding, its impact on dentin bond strength compared to devices like the KAVO™ appears minimal. Further research is needed to fully assess its potential in enhancing dentinal adhesion procedures.
Design, Construction, and Flight Performance of an Electrically Operated Fixed-Wing UAV
Authors: Panagiotopoulos Ilias , Sakellariou Lefteris , Hatziefremidis Antonios
Published: May 2024

The development of unmanned aerial vehicles (UAVs) has attracted much attention in the global community and aviation industry. As UAVs have the potential to be applied for multiple missions, the level of research into improving their design and flight performance has also increased. In this context, the present paper aims to present the design, construction, and flight performance of an electrically operated fixed-wing UAV. As a first step in the design process, key performance requirements are defined, such as the thrust required, the stall speed, the minimum drag velocity, and the minimum power velocity. Wing and associated power loadings are calculated according to the defined performance requirements. In addition, payload and endurance requirements are set up in order to determine the wing and tail areas, the total mass, the power requirements, and the motor size. Aerodynamics and stability designs are also calculated. After the completion of the design process, the manufacturing of the UAV follows by using appropriate materials. Flight tests were carried out for the evaluation of the UAV’s flight performance, where the success of the design was demonstrated.
The Role of Family Functionality and Its Relationship with Psychological Well-Being and Emotional Intelligence in High School Students
Authors: Molina Moreno Pablo , Fernández Gea Silvia , Molero Jurado María del Mar , Pérez-Fuentes María del Carmen , Gázquez Linares José Jesús
Published: May 2024

Adolescence is acknowledged as a critical transition stage in human development, during which factors such as family environment, psychological well-being, and emotional competencies are deemed crucial for optimal growth. Objective: A descriptive study with a quantitative, correlational, and cross-sectional approach was conducted to investigate: (1) how psychological well-being, emotional intelligence, and levels of family functioning are associated with each other; (2) the presence of gender disparities in psychological well-being, emotional intelligence, and family functioning; and (3) the identification of significant differences in psychological well-being and emotional intelligence based on family functioning. Methods: Participants were recruited from six different high schools in Spain. In total, 1092 secondary school students (584 females and 508 males) aged 12–17 years (M = 14.15) completed a series of instruments that were administered in person. Subsequently, data were statistically analysed and processed. Results: A positive correlation between family functioning, psychological well-being, and emotional intelligence was observed. In addition, significant gender differences were found in measures of psychological well-being, emotional intelligence, and family functioning. Finally, higher mean scores were identified for the high-functionality group when compared to the moderate-functionality and severe-dysfunctionality groups in both psychological well-being and emotional intelligence measures. Conclusions: The authors conclude by considering the family context as a key factor in adolescent development and propose future practical applications, such as programmes aimed at improving psychological well-being.
Assessing the Effects of Various Gaming Platforms on Players’ Affective States and Workloads through Electroencephalogram
Authors: Paranthaman Pratheep Kumar , Graham Spencer , Bajaj Nikesh
Published: May 2024

Game platforms have different impacts on player experience in terms of affective states and workloads. By studying these impacts, we can uncover detailed aspects of the gaming experience. Traditionally, understanding player experience has relied on subjective methods, such as self-reported surveys, where players reflect on their experience and effort levels. However, complementing these subjective measures with electroencephalogram (EEG) analysis introduces an objective approach to assessing player experience. In this study, we examined player experiences across PlayStation 5, Nintendo Switch, and Meta Quest 2. Using a mixed-methods approach, we merged subjective user assessments with EEG data to investigate brain activity, affective states, and workload during low- and high-stimulation games. We recruited 30 participants to play two games across three platforms. Our findings reveal that there is a statistically significant difference between these three platforms for seven out of nine experience factors. Also, three platforms have different impacts on play experience and brain activity. Additionally, we utilized a linear model to associate player experience aspects such arousal, frustration, and mental workload with different brain regions using EEG data.
Optimization of Integrated Energy Systems Based on Two-Step Decoupling Method
Authors: Zhang Linyang , Guo Jianxiang , Yu Xinran , Hui Gang , Liu Na , Ren Dongdong , Wang Jijin
Published: May 2024

An integrated energy system (IES) plays a key role in transforming energy consumption patterns and solving serious environmental and economic problems. However, the abundant optional schemes and the complex coupling relationship among each piece of equipment make the optimization of an IES very complicated, and most of the current literature focuses on optimization of a specific system. In this work, a simulation-based two-step decoupling method is proposed to simplify the optimization of an IES. The generalized IES is split into four subsystems, and a two-layer optimization method is applied for optimization of the capacity of each piece of equipment. The proposed method enables fast comparison among abundant optional configurations of an IES, and it is applied to a hospital in Beijing, China. The optimized coupling system includes the gas-fired trigeneration system, the GSHP, and the electric chiller. Compared with the traditional distributed systems, the emission reduction rate of CO2 and NOX for the coupling system reaches 153.8% and 314.5%, respectively. Moreover, the primary energy consumption of the coupling system is 82.67% less than that of the traditional distributed energy system, while the annual cost is almost at the same level.
Key Issues on Integrating 5G into Industrial Systems
Authors: Sun Jiadong , Chen Deji , Wang Quan , Lei Chao , Wang Mengnan , Li Ziheng , Xiao Yang , Zhang Weiwei , Liu Jiale
Published: May 2024

Under the auspice of further developing 5G mobile communication technology and integrating it with the latest advancements in the field of Industrial Internet-of-Things, this study conducts in-depth research and detailed analysis on the combination of 5G with industrial systems based on composite structures, communication network architectures, wireless application scenarios, and communication protocols. The status quo, development trend, and necessity of 5G mobile communication technology are explored and its potential in industrial applications is analyzed. Based on the current practical development level of 5G technology, by considering different requirements for bandwidth, real-time performance, and reliability in communication networks of industrial systems, this study proposes three feasible paths for the integration between 5G and industrial systems, including the method to use 5G in place of field buses. Finally, by introducing real-world cases, this study has successfully demonstrated the integration of 5G and industrial systems by extending 5G terminals as field bus gateways. This study provides valuable references for research and practice in related fields.
Aerial Inspection of High-Voltage Power Lines Using YOLOv8 Real-Time Object Detector
Authors: Bellou Elisavet , Pisica Ioana , Banitsas Konstantinos
Published: May 2024

The aerial inspection of electricity infrastructure is gaining high interest due to the rapid advancements in unmanned aerial vehicle (UAV) technology, which has proven to be a cost- and time-effective solution for deploying computer vision techniques. Our objectives are focused on enabling the real-time detection of key power line components and identifying missing caps on insulators. To address the need for real-time detection, we evaluate the latest single-stage object detector, YOLOv8. We propose a fine-tuned model based on YOLOv8’s architecture, trained on a custom dataset with three object classes, i.e., towers, insulators, and conductors, resulting in an overall accuracy rate of 83.8% (mAP@0.5). The model was tested on a GeForce RTX 3070 (8 GB), as well as on a CPU, reaching 243 fps and 39 fps for video footage, respectively. We also verify that our model can serve as a baseline for other power line detection models; a defect detection model for insulators was trained using our model’s pre-trained weights on an open-source dataset, increasing precision and recall class predictions (F1-score). The model achieved a 99.5% accuracy rate in classifying defective insulators (mAP@0.5).