bluuebunny/crossref_metadata_2025 huggingface dataset:
HUBUNGAN ANTARA TINGKAT STRES DALAM PEMBELAJARAN JARAK JAUH DI MASA PANDEMI COVID-19 DENGAN KEJADIAN DISMENORE PADA REMAJA PUTRI DI SMA ISLAM HASMI BOARDING SCHOOL KABUPATEN BOGOR
Authors: . Aisyah , Jayanti Resty , Dwimawati Eny
Published: February 2022

Salah satu upaya pencegahan penularan pandemi Covid-19 yang dilakukan pemerintah adalah dengan penerapan kebijakan physical atau social distancing yang menimbulkan beberapa dampak. Salah satunya adalah penerapan kegiatan belajar-mengajar dengan sistem dalam jaringan (daring) atau pembelajaran jarak jauh (PJJ) pada institusi pendidikan. Penelitian ini bertujuan untuk mengetahui adanya hubungan antara karakteristik (usia menarche, riwayat keluarga, kebiasaan berolahraga) dan tingkat stres dalam pembelajaran jarak jauh di masa pandemi Covid-19 dengan kejadian dismenore pada remaja putri di SMA Islam Hasmi Boarding School Kabupaten Bogor. Penelitian ini menggunakan metode kuantitatif dengan desain cross sectional dan populasi berjumlah 62 responden remaja putri. Teknik pengambilan sampel dengan menggunakan total sampling, yakni 61 siswi sebagai responden dikarenakan terdapat 1 siswi yang tidak sesuai dengan kriteria inklusi yang telah ditetapkan. Instrumen penelitian ini berupa kuesioner yang disebar secara online. Hasil penelitian menunjukkan bahwa usia menarche (p-value 1,000 > 0,05), riwayat keluarga (p-value 0,765 > 0,05), kebiasaan berolahraga (p-value 0,000 < 0,05), dan stres dalam pembelajaran jarak jauh (p-value 0,599 > 0,05). Hal ini menujukkan bahwa usia menarche, riwayat keluarga, dan stres dalam pembelajaran jarak jauh tidak memiliki hubungan yang signifikan, sedangkan kebiasaan berolahraga memiliki hubungan yang signifikan dengan kejadian dismenore pada remaja putri di SMA Islam Hasmi Boarding School Kabupaten Bogor. Saran bagi remaja putri untuk meningkatkan tindakan preventif guna mencegah risiko terjadinya dismenore dan untuk pihak sekolah agar memberikan penyuluhan mengenai dismenore sebagai upaya mencegah atau mengurangi risiko.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN HIPERTENSI PADA PRA LANSIA DI PUSKESMAS BOJONGGEDE TAHUN 2021
Authors: Oktaviani Elsa , Noor Prastia Tika , Dwimawati Eny
Published: February 2022

Hipertensi atau penyakit tekanan darah tinggi merupakan suatu keadaan peningkatan tekanan darah yang abnormal di dalam arteri yang menyebabkan suatu gangguan pada pembuluh darah yang dapat menimbulkan kerusakan lebih lanjut pada organ tubuh. Tujuan dari penelitian ini yaitu untuk menganalisis hubungan antara aktivitas fisik, merokok, dan tingkat stres dengan hipertensi pada pra lansia di Puskesmas Bojonggede. Jenis metode penelitian yang digunakan yaitu penelitian kuantitatif dengan pendekatan cross sectional. Jumlah sampel dalam penelitian ini sebanyak 87 responden dan didapatkan sampel aktual berjumlah 90 responden dengan teknik pengambilan sampling yaitu purposive sampling. Instrumen penelitian yang digunakan adalah lembar kuesioner FFQ, IPAQ, Indeks Brinkman, dan DASS 42. Analisis data yang digunakan yaitu analisis univariat dan bivariat (chi-square test). Hasil penelitian menunjukkan bahwa terdapat hubungan yang bermakna antara aktivitas fisik (p-value = 0,014), merokok     (p-value = 0,002), dan tingkat stres (p-value = 0,012) dengan kejadian hipertensi pada pra lansia. Hal yang dapat dilakukan oleh masyarakat pada usia pra lansia adalah dengan melakukan aktivitas fisik (olahraga) secara teratur, mengurangi bahkan menghentikan perilaku merokok serta mengendalikan stres.
A Description of the Cognitively Guided Instruction Professional Development Program in Florida: 2013–2020
Authors: Schoen Robert C. , Bray Wendy S. , Tazaz Amanda M. , Buntin Charity K.
Published: February 2022

Cognitively Guided Instruction (CGI) is a teacher PD program that has been found to have a potentially positive impact on student learning in mathematics through randomized controlled trials. Through a series of grant-funded projects led by FSU, approximately 2,000 Florida teachers have participated in CGI-based professional development in the past 8 years. This paper describes the core features of the CGI-based PD programs that were implemented in Florida during that time period. We provide this information to help researchers and practitioners to understand the context in which the associated research studies occurred and interpret the available and forthcoming findings related to the impacts of the interventions.
Pectin from Duckweed (Lemnaceae) As Potential Commercial Pectin and Its Gelling Function in Food Production: A Review
Authors: Hanis Nadia Yahya  , Nazariyah Yahaya  , Kamilah Huda Baihagi  , Norlelawati Ariffin  , Yahya Hafiza
Published: February 2022

Duckweed, a small flowering plant which comes from Lemnaceae family, has been rising in popularity to many researches and applications for its numerous valuable functional properties. One of its special features is fast growing plant and easily adapted to various types of regions which makes it attractive to be manipulated in many applications including in biofuel production, waste water treatment and also for pharmaceutical and medicinal purposes. Pectin is the common component found in plant cell wall and it has been used as food additive for its capability to gel, emulsify and stabilize food products.  Several requirements for commercial pectin such as galacturonic acid content (GalA) and degree of amidation have been regulated. Studies have proven that duckweed have significant amount of pectin which make it as a potential source of gelling agent in food industry. However, the structural properties of pectin from duckweed need to be investigated, in order to ensure if they meet the regulated requirements for industrial production. It is also to determine the suitability of duckweed pectin utilization in different type of food products since pectin of different sources have different structural characteristics, thus exhibit different gelling capability. This present review discusses on the potential of pectin from duckweed species to be utilized as food additive with gelling function in food products. Several extraction methods also have been reviewed, which each of them showed different efficiency and affect the extracted pectin characteristics.
Norm attaining multilinear forms on the spaces $c_0$ or $l_1$
Authors: Kim Sung Guen
Published: February 2022

T∈L(nE)T∈L(nE) is called a norming attaining if there are x1,…,xn∈Ex1,…,xn∈E such that ∥x1∥=⋯=∥xn∥=1‖x1‖=⋯=‖xn‖=1 and |T(x1,…,xn)|=∥T∥,|T(x1,…,xn)|=‖T‖, where L(nE)L(nE) denotes the space of all continuous nn-linear forms on E.E. We investigate norm attaining multilinear forms on c0c0 or l1.l1.
La planificación en la producción y su incidencia en la optimización de los procesos
Authors: Soto Chávez Luis Enrique , Ugalde Vicuña José William
Published: February 2022

Las organizaciones actualmente batallan a diario para subsistir en el tiempo, adaptándose a las nuevas tendencias de herramientas administrativas y de la tecnología, tratando de conseguir los objetivos planeados y por ende, conseguir tanto como el crecimiento económico como organizacional, con el fin de mantener los estándares máximos  de producción que conlleven al logro de esos objetivos, para ello deben entonces, optimizar cada uno de los procesos que se llevan a cabo y que de manera directa o indirecta se relacionan con el proceso de producción, el cual representa uno de los más importantes de toda organización, puesto que es a través de este que se generan los bienes o servicios que se ofrecerán a los consumidores y que por supuesto, son los que generan el ingreso. De allí a que constantemente las organizaciones se esfuerzan en buscar y aplicar distintas técnicas que le permitan asegurar el buen funcionamiento de todos los procesos, representando la planificación un proceso medular, que permite definir cada uno de los pasos que se lleven a cabo para alcanzar las metas, así como también prevenir la detección de problemas o defectos que se presenten, a fin de corregirlos a tiempo y lograr contrarrestar cualquier contratiempo.
Macroelements, their role in the human organism in living conditions in territories contaminated as a result of the accident at the ChAES
Authors: Matasar I.T. , Petryschenko L.M. , Matasar T.V.
Published: February 2022

The article shows the value of macronutrients, which, along with other food ingredients, form various structures of the body. The data on the content of macronutrients in the diets of the population of different age groups for the period 2004-2020, living in the settlements of the Kyiv region and exposed to the impact of the consequences of the Chernobyl accident, are presented.

Aim of the Research. The aim of the study was to summarize data on the content of minerals in the diet of the population living under the influence of radiation exposure. The main attention is paid to organic elements (phosphorus, potassium, sulphur, chlorine, calcium, magnesium and iron), which form almost 98% of the chemical composition of the cell. Their total content is up to 1.9 % of the mass of the human body.

Material and Methods. To achieve this goal, a set of methods was used, in particular: bibliographic — a theoretical analysis was carried out and the data from scientific literature was generalized; questionnairesurvey — the actual content of macronutrients in the diets of different age groups and mathematics were analyzed. Statistical data processing was carried out using modern methods of medical statistics.

Results and Discussion. Regular provision of the body with all the necessary nutrients is of great importance for maintaining health, performance and active longevity of a person. Our longterm research conducted among the population of ecologically dangerous territories of Ukraine found that the content of macronutrients in the diets of adults, children and pregnant women did not meet physiological needs.

Conclusion. The content of macronutrients in the diet of the surveyed population was unbalanced. Diets deficient in the content of calcium (Ca) and magnesium (Mg), the optimal ratio between macronutrients is disturbed, which can be the cause of premorbid conditions and be the reason for the formation of alimentary and alimentary-dependent diseases. The article is relevant for family doctors, hygienists, nutritionists, nutritionists and individuals interested in nutritional problems.

Key words: minerals, nutrition, macronutrients, physiological role of macronutrients, recommended daily intake, sources of supply, population.
Vitamin D toxicity syndrome: a toxicologist's view
Authors: Padalka V.M. , Kurdil N.V. , Zinovieva M.L. , Petrashenko H.I.
Published: February 2022

Vitamin D-related health problems remain a global health problem. The growing number of prescriptions of vitamin D by doctors during the COVID-19 pandemic and the increase in self-intake of vitamin D by the population carries the risk of exogenous hypervitaminosis D, or a syndrome known as vitamin D toxicity.

Aim: to summarize the results of scientific research on the vitamin D toxicity, and some aspects related to its overdose.

Material and Methods: used methods of content analysis, system and comparative analysis; materials of scientific reviews and separate researches devoted to biochemistry and toxicology of vitamin D (Elsevier, PubMed, ToxNet) with depth of search to 20 years.

Results and Discussion. Due to the well-known health risks of vitamin D deficiency, it has become a popular dietary supplement, as evidenced by the progressive growth of both thematic scientific publications (PubMed) and its consumption in many countries around the world. The use of pharmaceuticals and dietary supplements is the most common cause of overdose. A review of cases of vitamin D toxicity caused by errors in prescribing or administering the required dose has shown that they may occasionally be accompanied by the development of intoxication. There are many forms of exogenous and endogenous vitamin D toxicity syndrome. Vitamin D toxicity syndrome includes the following symptoms: loss of consciousness, apathy, intermittent vomiting, abdominal pain, polyuria, polydipsia, dehydration, and hypercalcemia, which, although uncommon, can be life-threatening if not detected timely, and is an important symptom in the differential diagnosis in patients with hypercalcemia. Despite differing opinions on the target concentration of 25(OH)D or recommended doses of vitamin D for the general population, it was determined that the concentration of 25 (OH) D> 150 ng/ml is a significant risk of developing vitamin D toxicity syndrome, and vitamin D deficiency treatment regimens at high doses require regular monitoring.

Conclusions: There is a growing public awareness of the health benefits of vitamin D; however, the increase in its consumption carries, inter alia, the risk of a specific syndrome ‒ the vitamin D toxicity. Family physicians should be informed about the danger of exceeding the recommended (age and body weight) doses, and carry out explanatory work with the public to raise awareness of adverse effects vitamin D overdose.

Key Words: vitamin D, toxicity.
Perencanaan Usaha Dagang Gula Semut Sari Aren
Authors: Winarti Kurnia , Abdullah Ilham , Sofino Sofino
Published: February 2022

Keberhasilan suatu usaha pastinya selalu berdampingan dengan suatu perencanaan yang baik. Perencanaan yang baik dimulai dari memaksimalkan tujuan dan target yang ingin dicapai, merumuskan strategi dan memfasilitasi saran dan prasarana yang memadai shingga proses kegiatannya terlaksana dengan baik. Penelitian ini bertujuan untuk mendapatkan informasi secara sistemasi berkaitan dengan perencanaan usaha dagang gula semut sari aren di Kabupaten Rejang Lebong. Penelitian dilakukan dengan menggunakan metode kualitatif. Data yang dikumpulkan memalui teknik wawancara, observasi dan dokumentasi. Dari perencanaan yang dilakukan di usaha dagang gula semut sari aren dapat disimpulkan bahwa perencanaan usaha dagang gula semut sari aren di Kabupaten Rejang Lebong memiliki tujuan untuk meningkatkan nilai tambah gula aren batok menjadi gula semut yang yang secara ekonomi memiliki nilai jual yang lebih dibandingkan dengan gula aren batok, menciptakan lapangan pekerjaan dan untuk menambah pendapatan ekonomi keluarga. Menggunakan strategi pemasaran dengan media sosial seperti instagram, facebook,whatshap dan tokopedia. Sarana dan prasaran yang ada sudah mendukung seperti satu set mesin pengolahan gula semut. Pada pengorganisasian sudah berjalan maksimal fungsi/tugas disetiap anggita sudah sesuai dengan tupoksi masing-masing.
Pelaksanaan Pembelajaran Life Skill Menjahit Kelompok Belajar Paket C Di PKBM Mutiara Bintang
Authors: Rodiah Rodiah , Sofino Sofino , Abdullah Ilham
Published: February 2022

PKBM Mutiara Bintang Kota Bengkulu merupakan salah satu lembaga yang menyelenggarakan pelaksanaan pembelajaran life skill menjahit bagi kelompok belajar paket C pada mata pelajaran muatan lokal dengan bertujuan meningkatkan kemampuan keterampilan menjahit. Penelitian ini bertujuan untuk mengetahui Pelaksanaan pembelajaran life skill menjahit mulai dari perencanaan pembelajaran yang telah dibuat oleh pihak lembaga, proses pembelajaran dari  segi kegiatan belajar, faktor penghambat dan faktor pengdukung dalam pelaksanaan pembelajaran, evaluasi pelaksanaan pembelajaran dan keberhasilan hasil belajar dalam pelaksanaan pembelajaran life skill menjahit bagi kelompok belajar. Penelitian dilakukan dengan menggunakan metode kualitatif. Data yang dikumpulkan teknik wawancara, observasi dan dokumentasi. Hasil penelitian pelaksanaan pembelajaran life skill menjahit bagi kelompok belajar paket C yaitu diawali dengan rekrutmen kelompok belajar, persiapan kurikulum,materi,metode dan media dan proses pembelajaran yang dilaksanakan dua kali dalam seminggu dan faktor pengdukung dari segi sarana prasarana dan evaluasi dilakukan dengan dilihat dari hasil belajar paket C dan keberhasilan hasil belajar dilihat dari pembuatan tutup  untuk (kulkas,galon dan magicom) dan sarung bantal.
Avaliação do perfil das vítimas de fraturas de fêmur atendidos em um hospital de urgência e emergência na amazônia ocidental brasileira
Authors: Gutzeit Ennely Mendonça , Lopes Thiago Vaz , Campos Silvecler Cortijo de , Barreto Breno de Oliveira Chagas , Wehbe Camila , Lopes Iara Vaz , Silva Josiel Neves da , Souza João Gustavo da Silva Garcia de , Rodrigues Juliana Costa , Reimann Raissa Santos , Muniz Igor Mansur
Published: February 2022

As fraturas do fêmur apresentam maior morbimortalidade em todos os níveis de atenção à saúde. Dessa forma, as quedas em idosos são bastante frequentes pois, acarretam na diminuição da capacidade funcional e consequências graves para esses pacientes. Os acidentes de trânsito são relevantes, acometendo mais, os adultos jovens do sexo masculino sendo a imprudência a principal causa desses acidentes. Avaliou-se o perfil das vítimas de fraturas de fêmur atendidos em um hospital de urgência e emergência de Porto Velho/RO, através da estratificação dos dados apresentados por sexo, faixa etária, lado acometido e mecanismo de trauma. A metodologia deste estudo foi realizada através de dados coletados a partir de prontuários médicos, deliberados pelo sistema HOSPUB. Os resultados, foram avaliados o quantitativo de admissões traumáticas pela ortopedia no período de janeiro a abril do ano de 2021, totalizando 2.043 pacientes atendidos na sala vermelha e ambulatório, desse total 63 são de fratura de fêmur 3,08% (63/2.043), sendo a distribuição desses nos meses; janeiro 41,2% (26/63), fevereiro 17,4% (11/63), março 25,3% (16/63) e abril 15,8% (10/63). Avaliou-se a variável sexo, dentre os pacientes atendidos, observou-se um predomínio do sexo masculino na faixa etária de 21-49 anos 30,5% (19/63) estando equivalente quando comparado com outros resultados, sendo esse o sexo mais acometido por acidentes e violências. Conclui-se, que o perfil das vítimas com fratura de fêmur tem predomínio no sexo feminino quando tratando de idosos, onde a principal causa são as quedas. Já os adultos jovens a maior prevalência e do sexo masculino tendo como o principal mecanismo de trauma os acidentes de motocicleta.
Thermal Analysis of the Essential Oil of Aniba rosaeodora Ducke by TGA and DSC
Authors: Teles Rogério de Mesquita , Mouchrek Filho Victor Elias
Published: February 2022

Thermal analysis comprises a group of techniques to measure a physical property of a sample subjected to controlled temperature programming, including thermogravimetry (TGA), derivative thermogravimetry (DTG) and differential scanning calorimetry (DSC). The species Aniba duckei Kostermans, synonymous with Aniba rosaeodora Ducke, occurs in the Amazon and is also known as rosewood. Essential oils are complex oily aromatic liquids obtained by extraction from highly volatile aromatic plant materials as secondary metabolites. This research aimed to chemically and thermally characterize the essential oil of Aniba duckei. Gas chromatography was used for the quantification, by the external standard method, of the main component. The thermal study of the oil and the linalool standard was carried out using DSC and TG-DTG. The essential oil yield was 1.93% and the analysis by GC-MS confirmed the majority presence of linalool, with a concentration of 89.34% in the oil. The technical analysis revealed some similarity between the curves of pure linalool and essential oil, which is attributed to the high content of linalool in the oil. The differences between the boiling points and enthalpies of the linalool and oil pattern are justified by the presence of minor components, their concentrations in the oil and because they are substances of different polarities, molecular masses and intermolecular forces. The techniques proved to be efficient to characterize the oil. The results of the thermal analysis of the essential oil of the Aniba rosaeodora plant species are unprecedented, enabling the determination of linalool in by DSC.
Evaluation of the influence of calcium chloride on the behavior of phases of nanosystems applied in the larvicidal control of Aedes aegypti
Authors: Santos Adriana de Jesus , Macêdo Nathália Araújo , Mendonça Marcos Rafael das Chagas , Cavalcanti Sócrates Cabral de Holanda , Sarmento Victor Hugo Vitorino , Lira Ana Amélia Moreira , Araujo Guilherme Rodolfo Souza de , Santos Cochiran Pereira dos , Souza Roberto Rodrigues de , Nunes Rogéria de Souza
Published: February 2022

Systems stabilized by surfactants in order to incorporate different substances at their interfaces, such as hydrophilic polymers and active compounds, are systems capable of establishing vector control of Aedes aegypti. The system was obtained through the surface tension of PPG-5-CETETH-20/calcium chloride dispersion at concentrations of 0.2%, 0.4%, 0.8%, 1% and 2%, determining the CMC of each sample. Then, a binary study was performed and the system structures were evaluated by Polarized Light Microscopy (PLM) and rheological analysis. Biological analysis was performed to assess the mean lethal concentration (LC50) against Aedes aegypti larvae and toxicity to non-target organisms in Artemia salina. In this sense, the objective of this work was to evaluate the influence of calcium chloride on the behavior of phases and on the biological activity of formulations based on the self-aggregation of surfactants, an alternative larval insecticide to be used as a replacement for larval insecticides already on the market.
Coexistência de tumores estromais gastrointestinais (GISTs), feocromocitoma e paragangliomas em uma paciente com Neurofibromatose tipo 1: Relato de Caso
Authors: Dantas Raiana Carol de Medeiros , Fernandes Lucca Ferdinando Queiroz , Carvalho Iago Tavares de , Santos Igor Henrique , Freitas Lucas Ribeiro de Moraes , Lucena Renner Cassio Nunes de , Barbalho Vitor Luiz de Andrade
Published: February 2022

A neurofibromatose tipo 1 (NF1), consiste em uma doença genética. Quando comparada às outras duas formas, neurofibromatose tipo 2 (NF2) e schwannomatose, a NF1 é a apresentação mais comum. O quadro clínico geralmente se apresenta como máculas, sardas axilares e/ou inguinais, nódulos de Lisch (hamartomas de íris) e neurofibromas. O presente estudo trata-se de um relato de caso, o qual tem como objetivo relatar as repercussões e achados raros em uma idosa diagnosticada com NF1. A clínica da paciente começou há cerca de 45 anos quando buscou um serviço de saúde devido crises recorrentes de diarréia e hérnia em região inguinal. Foi solicitada uma USG de abdome total que evidenciou uma massa em região retropancreática característica de paraganglioma. Após 4 anos, a paciente possuía hipertensão primária de difícil controle com picos paroxísticos, sendo em seguida diagnosticado um feocromocitoma por meio de exames de imagem e exames laboratoriais. Durante o acompanhamento de rotina, uma ressonância magnética (RM) de abdome e pelve identificou nódulo sólido mantendo íntima relação com alças intestinais de delgado, que na imunohistoquímica tratava-se de um Tumor do Estroma Gastrointestinal (GIST). A paciente segue com acompanhamento oncológico na sua cidade e encontra-se sem queixas. Ultimamente tem apresentado lapsos de memória intermitentes e alguns episódios de quedas. Dessa forma, após uma revisão da literatura, descobriu-se que o tema em questão raramente é discutido, verificando-se escassos registros da existência simultânea dos três tumores citados, o que reforça, portanto, a importância deste estudo.
Procurement management of strategic inputs in coping with COVID-19: scoping review protocol
Authors: Silva Rondineli Mendes da , Caetano Rosangela , Luiza Vera Lucia , Vasconcelos Daniela Moulin Maciel de , Chaves Luisa Arueira , Paranhos Leandro  Oliveira , Muniz Angelúcia , Osorio-de-Castro Claudia Garcia Serpa
Published: February 2022

The health crisis triggered by the COVID-19 pandemic has challenged public management in several countries to ensure the timely and efficient procurement of the various health technologies necessary to cope with it, such as medicines, diagnostic tests, personal protective equipment (PPE) and medical materials/equipment, among others. This article introduces a protocol for a scoping review that aims to map and synthesize studies portraying the management capacity related to public procurement of inputs used in coping with the crisis arising from COVID-19. The protocol is intended to document the processes involved in the methodological planning and execution of a scoping review guided by Joanna Briggs Institute guidelines and developed using the 2015 PRISMA-Protocols (PRISMA-P) checklist. The PCC strategy (population, concept and context) systematized the search for studies published in MEDLINE, LILACS, Scopus, Embase, Web of Science and WHO-COVID-19 (Global literature on coronavirus disease), as well as in the gray literature, by September 2021. The selection of articles will be carried out in two steps (titles and abstracts, followed by the assessment of the full text of the articles), by two independent reviewers, with the resolution of disagreements by a third reviewer. The results will be analyzed qualitatively/quantitatively and will be organized by themes. The checklist present in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) will be used to guide the final review report. The protocol was registered in the Open Science Framework under the number 10.17605/OSF.IO/W6KHY.
Protecting the Consumer Rights in the Digital Economic Era: Future Challenges in Indonesia
Authors: Arifin Ridwan , Kambuno Juan Anthonio , Waspiah Waspiah , Latifiani Dian
Published: February 2022

The emerging technological prospects affected many aspects, including consumer protection. The creation of data and computer-driven innovation would derive several advantages for consumers. Innovative products and services and new ways in which goods and services are developed and delivered. This paper aims to analyse how Indonesian legal policy on protection consumer rights in the digital era. The paper emphasized that it would advise against believing that policy is unreasonably permitted to give way to the technological agenda, whilst accepting that adaptations should be made and also that there should be a critical review of whether existing forms of regulation are needed in the digital economy of Indonesia. Regulations concerning to the protecting consumer rights in the world of e-commerce are still worrying even though many sectoral regulations have been promulgated, as well as weak supervision and lack of strict law enforcement in resolving consumer disputes. Trade regulation via the internet still raises many conceptual or theoretical questions that indicate the need to develop more detailed conceptual and theoretical explanations to the need for more complex laws and regulations to be able to protect consumers properly. More than that, national regulations are dealing with the context of trade through the internet, which transcends national boundaries without always being controlled through conventional means.
The Discourse on Legal Utopia for The People with Disabilities in Order to Remove the Educational Segregation
Authors: Abdussamad Zamroni
Published: February 2022

The right to education for persons with disabilities is still a contemporary legal issue with legal and social problems. The laws and regulations governing the right to education with disabilities are still segregated for the research objectives, namely the Pattern of analyzing the educational arrangements for persons with disabilities and the ideal arrangements for achieving equality in education for persons with disabilities in Indonesia. This research method is categorized into normative legal research types. It is based on the issues and or themes raised as research topics using a philosophical and analytical research approach that is analyzed descriptively. The study results show that the segregated polarization of education for persons with disabilities is contained in Article 10 of Law Number 8 of 2016 concerning Persons with Disabilities and Articles 5, 15 and 32 of Law Number 20 of 2003 concerning the National Education System. The arrangement divides persons with disabilities into particular groups that have an impact on a homogeneous social environment. Therefore, the ideal design is educational equality, as in the United States, where people with disabilities attend regular schools. Besides that, it is necessary to have equal education for people with disabilities in the laws and regulations in Indonesia.
Responsibilities of Financial Technology Company Due To Failure to Pay By Loan Recipients
Authors: Janisriwati Sylvia
Published: February 2022

One form of business is due to current developments in financial technology (abbreviated as fintech), which means using technology to provide financial solutions. This study aims to see the responsibility of PT. Dana Agung Nusantara as the financial technology (fintech) lending provider due to default by lending recipients in the case of Central Jakarta Commercial Court Decision Number 113/Pdt.Sus-PKPU/2021/PN Jkt.Pst. This research is normative juridical research. In this study, the source of legal materials used consisted of 3 (three) legal materials, namely primary, secondary and tertiary legal materials. The technique of collecting data on legal materials is by using a literature study model using analysis of legal materials, which is used in descriptive qualitative content analysis. The results showed that the responsibility of PT. Dana Agung Nusantara as the financial technology (fintech) lending provider due to default by loan recipients by the case of Central Jakarta Commercial Court Decision Number 113/Pdt.Sus- PKPU/2021/PN Jkt.Pst that according to an OJK spokesperson, the party is responsible if The fintech collapsed is a P2P lending fintech provider. Meanwhile, if the borrower causes a default, it is the responsibility of the lender or investor.
Counterexample of the Riemann Hypothesis
Authors: Vega Frank
Published: February 2022

By proving the existence of a zero-free region for the Riemann zeta-function, de la Vall{\'e}e-Poussin was able to bound $\theta(x) = x + O(x \times \exp(-c_{2} \times \sqrt{\log x}))$, where $\theta(x)$ is the Chebyshev function and $c_{2}$ is a positive absolute constant. Under the assumption that the Riemann hypothesis is true, von Koch deduced the improved asymptotic formula $\theta(x) = x + O(\sqrt{x} \times \log^{2} x)$. We prove when $\theta(x) = x + \Omega(\sqrt{x} \times \log^{2} x)$, then the Riemann hypothesis is false.
Naview: A d3.js Based JavaScript Library for Drawing and Annotating Voltage-Gated Sodium Channels Membrane Diagrams
Authors: Afonso Marcelo Querino Lima , da Fonseca Júnior Néli José , Miranda Thainá Godinho , Bleicher Lucas
Published: February 2022

Voltage-gated sodium channels (Nav) are membrane proteins essential to initiating and propagating action potential in neurons and other excitable cells. For a given organism there are often multiple, specialized sodium channels found in different tissues, whose mutations can cause deleterious effects observed in numerous diseases. Consequently, there is high medical and pharmacological interest in these proteins. Scientific literature often uses membrane diagrams to depict important patterns in these channels including the six transmembrane segments (S1–S6) present in four different homologous domains (D1–D4), the S4 voltage sensors, the pore-lining residue segments and the ion selectivity filter residues, glycosylation and phosphorylation residues, toxin binding sites and the inactivation loop, among others. Most of these diagrams are illustrated either digitally or by hand and programs specifically dedicated to the interactive and data-friendly generation of such visualizations are scarce or non-existing. This paper describes Naview, an open-source javascript visualization compatible with modern web browsers for the dynamic drawing and annotation of voltage-gated sodium channels membrane diagrams based on the D3.js library. By using a graphical user interface and combining user-defined annotations with optional UniProt code as inputs, Naview allows the creation and customization of membrane diagrams. In this interface, a user can also map and display important sodium channel properties, residues, regions and their relationships through symbols, colors, and edge connections. Such features can facilitate data exploration and provide fast, high-quality publication-ready graphics for this highly active area of research.
Isolation and Identification of Polyphenols From Fresh Sweet Sorghum Stems and Their Antibacterial Mechanism Against Foodborne Pathogens
Authors: Chen Hao , Xu Yifei , Chen Haoyu , Liu Hao , Yu Qunli , Han Ling
Published: February 2022

As a C4 energy crop widely planted all over the world, sweet sorghum is mainly used in sugar making and brewing. Fresh sweet sorghum stalks contain many natural ingredients that have antioxidant properties and can significantly inhibit the growth of foodborne pathogens. In this study, the polyphenols in sweet sorghum were extracted by acid ethanol and ion precipitation, and the types of polyphenols were determined by HPLC-MS. The polyphenol content in fresh sweet sorghum stalks was 5.77 mg/g after process optimization with 18 types of phenolic acids identified. The extract had a total antioxidant capacity of 9.4 μmol Trolox/mL. Polyphenol extract of sweet sorghum displayed antibacterial activity against Staphylococcus aureus, Escherichia coli, Listeria spp., and Salmonella spp. The extract increased the conductivity of cell suspensions by destroying the membrane structure, resulting in leakage of cell electrolytes. Changes in bacterial morphology and internal structure were indicated. The data describe an optimized process to extract polyphenols from sweet sorghum stalks and the methodology to identify the major components within the extract. The data provide a novel option for the comprehensive utilization of fresh sweet sorghum stalks.
Application of Nanomedicine in Inner Ear Diseases
Authors: Lin Qianyu , Guo Qiong , Zhu Mingchao , Zhang Juanli , Chen Bei , Wu Tingting , Jiang Wei , Tang Wenxue
Published: February 2022

The treatment of inner ear disorders always remains a challenge for researchers. The presence of various physiological barriers, primarily the blood–labyrinth barrier (BLB), limits the accessibility of the inner ear and hinders the efficacy of various drug therapies. Yet despite recent advances in the cochlea for repair and regeneration, there are currently no pharmacological or biological interventions for hearing loss. Current research focuses on the localized drug-, gene-, and cell-based therapies. Drug delivery based on nanotechnology represents an innovative strategy to improve inner ear treatments. Materials with specific nanostructures not only exhibit a unique ability to encapsulate and transport therapeutics to the inner ear but also endow specific targeting properties to auditory hair cells as well as the stabilization and sustained drug release. Along with this, some alternative routes, like intratympanic drug delivery, can also offer a better means to access the inner ear without exposure to the BLB. This review discusses a variety of nano-based drug delivery systems to the ear for treating inner ear diseases. The main factors affecting the curative efficacy of nanomaterials are also discussed. With a deeper understanding of the link between these crucial factors and the clinical effect of nanomaterials, it paves the way for the optimization of the therapeutic activity of nanocarriers.
Self-Tuning Control of Manipulator Positioning Based on Fuzzy PID and PSO Algorithm
Authors: Liu Ying , Jiang Du , Yun Juntong , Sun Ying , Li Cuiqiao , Jiang Guozhang , Kong Jianyi , Tao Bo , Fang Zifan
Published: February 2022

With the manipulator performs fixed-point tasks, it becomes adversely affected by external disturbances, parameter variations, and random noise. Therefore, it is essential to improve the robust and accuracy of the controller. In this article, a self-tuning particle swarm optimization (PSO) fuzzy PID positioning controller is designed based on fuzzy PID control. The quantization and scaling factors in the fuzzy PID algorithm are optimized by PSO in order to achieve high robustness and high accuracy of the manipulator. First of all, a mathematical model of the manipulator is developed, and the manipulator positioning controller is designed. A PD control strategy with compensation for gravity is used for the positioning control system. Then, the PID controller parameters dynamically are minute-tuned by the fuzzy controller 1. Through a closed-loop control loop to adjust the magnitude of the quantization factors–proportionality factors online. Correction values are outputted by the modified fuzzy controller 2. A quantization factor–proportion factor online self-tuning strategy is achieved to find the optimal parameters for the controller. Finally, the control performance of the improved controller is verified by the simulation environment. The results show that the transient response speed, tracking accuracy, and follower characteristics of the system are significantly improved.
Biochemical and Molecular Dynamics Study of a Novel GH 43 α-l-Arabinofuranosidase/β-Xylosidase From Caldicellulosiruptor saccharolyticus DSM8903
Authors: Saleh Md. Abu , Mahmud Shafi , Albogami Sarah , El-Shehawi Ahmed M , Paul Gobindo Kumar , Islam Shirmin , Dutta Amit Kumar , Uddin Md. Salah , Zaman Shahriar
Published: February 2022

The complete hydrolysis of xylan can be facilitated by the coordinated action of xylanase and other de-branching enzymes. Here, a GH43 α-l-arabinofuranosidase/β-xylosidase (CAX43) from Caldicellulosiruptor saccharolyticus was cloned, sequenced, and biochemically investigated. The interaction of the enzyme with various substrates was also studied. With a half-life of 120 h at 70°C, the produced protein performed maximum activity at pH 6.0 and 70°C. The enzyme demonstrated a higher activity (271.062 ± 4.83 U/mg) against para nitrophenol (pNP) α-L-arabinofuranosides. With xylanase (XynA), the enzyme had a higher degree of synergy (2.30) in a molar ratio of 10:10 (nM). The interaction of the enzyme with three substrates, pNP α-L-arabinofuranosides, pNP β-D-xylopyranosides, and sugar beet arabinan, was investigated using protein modeling, molecular docking, and molecular dynamics (MD) simulation. During the simulation time, the root mean square deviation (RMSD) of the enzyme was below 2.5 Å, demonstrating structural stability. Six, five, and seven binding-interacting residues were confirmed against pNP α-L-arabinofuranosides, pNP β-D-xylopyranosides, and arabinan, respectively, in molecular docking experiments. This biochemical and in silico study gives a new window for understanding the GH43 family’s structural stability and substrate recognition, potentially leading to biological insights and rational enzyme engineering for a new generation of enzymes that perform better and have greater biorefinery utilization.
Angiogenesis, Osseointegration, and Antibacterial Applications of Polyelectrolyte Multilayer Coatings Incorporated With Silver/Strontium Containing Mesoporous Bioactive Glass on 316L Stainless Steel
Authors: Kuo Yi-Jie , Chen Chia-Hsien , Dash Pranjyan , Lin Yu-Chien , Hsu Chih-Wei , Shih Shao-Ju , Chung Ren-Jei
Published: February 2022

The main causes for failure in implant surgery are prolonged exposure of implants or wound and tissue ischemia. Bacterial infection caused by the surrounding medical environment and equipment is also a major risk factor. The medical risk would be greatly reduced if we could develop an implant coating to guide tissue growth and promote antibacterial activity. Mesoporous bioactive glasses are mainly silicates with good osteoinductivity and have been used in medical dentistry and orthopedics for several decades. Strontium ions and silver ions could plausibly be incorporated into bioactive glass to achieve the required function. Strontium ions are trace elements in human bone that have been proposed to promote osseointegration and angiogenesis. Silver ions can cause bacterial apoptosis through surface charge imbalance after bonding to the cell membrane. In this study, functional polyelectrolyte multilayer (PEM) coatings were adhered to 316L stainless steel (SS) by spin coating. The multilayer film was composed of biocompatible and biodegradable collagen as a positively charged layer, γ-polyglutamic acid (γ-PGA) as a negatively charged layer. Chitosan was incorporated to the 11th positively charged layer as a stabilizing barrier. Spray pyrolysis prepared mesoporous bioactive glass incorporated with silver and strontium (AgSrMBG) was added to each negatively charged layer. The PEM/AgSrMBG coating was well hydrophilic with a contact angle of 37.09°, hardness of 0.29 ± 0.09 GPa, Young’s modulus of 5.35 ± 1.55 GPa, and roughness of 374.78 ± 22.27 nm, as observed through nano-indention and white light interferometry. The coating’s antibacterial activity was sustained for 1 month through the inhibition zone test, and was biocompatible with rat bone marrow mesenchymal stem cells (rBMSCs) and human umbilical vein endothelial cells (HUVECs), as observed in the MTT assay. There was more hydroxyapatite precipitation on the PEM/AgSrMBG surface after being soaked in simulated body fluid (SBF), as observed by scanning electron microscopy (SEM) and X-ray diffraction (XRD). In both in vitro and in vivo tests, the PEM/AgSrMBG coating promoted angiogenesis, osseointegration, and antibacterial activity due to the sustained release of silver and strontium ions.
The Effect of Calcium Source on Pb and Cu Remediation Using Enzyme-Induced Carbonate Precipitation
Authors: Wang Lin , Cheng Wen-Chieh , Xue Zhong-Fei
Published: February 2022

Heavy metal contamination not only causes threat to human health but also raises sustainable development concerns. The use of traditional methods to remediate heavy metal contamination is however time-consuming, and the remediation efficiency may not meet the requirements as expected. The present study conducted a series of test tube experiments to investigate the effect of calcium source on the lead and copper removals. In addition to the test tube experiments, numerical simulations were performed using Visual MINTEQ software package considering different degrees of urea hydrolysis derived from the experiments. The remediation efficiency degrades when NH4+ and OH− concentrations are not sufficient to precipitate the majority of Pb2+ and Cu2+. It also degrades when CaO turns pH into highly alkaline conditions. The numerical simulations do not take the dissolution of precipitation into account and therefore overestimate the remediation efficiency when subjected to lower Pb(NO3)2 or Cu(NO3)2 concentrations. The findings highlight the potential of applying the enzyme-induced carbonate precipitation to lead and copper remediations.
Generative Adversarial Networks for Data Generation in Structural Health Monitoring
Authors: Luleci Furkan , Catbas F. Necati , Avci Onur
Published: February 2022

Structural Health Monitoring (SHM) has been continuously benefiting from the advancements in the field of data science. Various types of Artificial Intelligence (AI) methods have been utilized to assess and evaluate civil structures. In AI, Machine Learning (ML) and Deep Learning (DL) algorithms require plenty of datasets to train; particularly, the more data DL models are trained with, the better output it yields. Yet, in SHM applications, collecting data from civil structures through sensors is expensive and obtaining useful data (damage associated data) is challenging. In this paper, one-dimensional (1-D) Wasserstein loss Deep Convolutional Generative Adversarial Networks using Gradient Penalty (1-D WDCGAN-GP) is utilized to generate damage-associated vibration datasets that are similar to the input. For the purpose of vibration-based damage diagnostics, a 1-D Deep Convolutional Neural Network (1-D DCNN) is built, trained, and tested on both real and generated datasets. The classification results from the 1-D DCNN on both datasets resulted in being very similar to each other. The presented work in this paper shows that, for the cases of insufficient data in DL or ML-based damage diagnostics, 1-D WDCGAN-GP can successfully generate data for the model to be trained on.
Playful Communication and Care: Exploring Child-Centred Care of Young Children With Type 1 Diabetes Through the Framework of Zone of Proximal Development
Authors: DeCosta Patricia , Grabowski Dan , Jespersen Louise Norman , Skinner Timothy C.
Published: February 2022

Introduction

Little is known about the psychosocial experiences and care needs of young children under the age of 7 years who have been diagnosed with type 1 diabetes. To address this knowledge gap, we examine children’s psychosocial care needs through the lens of child-centred care and the framework of Zone of Proximal Development.

Objectives

To explore current care practices for young children with diabetes and identify aspects of child-centred care already successfully integrated into current practice.

Method

Individual face-to-face, semi-structured interviews were conducted with 20 Healthcare Professionals, representing 11 of 17 paediatric diabetes clinics in Denmark.

Results

Our data provided valuable insights into existing child-centred practices. Our analysis identified practices covering four main themes: 1. Accommodating immediate emotional needs, 2. Putting children before diabetes, 3. Encouraging meaningful participation, 4. Playful communication.

Discussion

Healthcare Professionals provided child-centred care, largely through play-based approaches that make diabetes care meaningful and relevant. Such practices provide the scaffolding necessary to enable young children to gradually engage, comprehend and participate in their own care.
Anosmin-1-Like Effect of UMODL1/Olfactorin on the Chemomigration of Mouse GnRH Neurons and Zebrafish Olfactory Axons Development
Authors: Di Schiavi Elia , Vistoli Giulio , Moretti Roberta Manuela , Corrado Ilaria , Zuccarini Giulia , Gervasoni Silvia , Casati Lavinia , Bottai Daniele , Merlo Giorgio Roberto , Maggi Roberto
Published: February 2022

The impairment of development/migration of hypothalamic gonadotropin-releasing hormone (GnRH) neurons is the main cause of Kallmann's syndrome (KS), an inherited disorder characterized by hypogonadism, anosmia, and other developmental defects. Olfactorin is an extracellular matrix protein encoded by theUMODL1(uromodulin-like 1) gene expressed in the mouse olfactory region along the migratory route of GnRH neurons. It shares a combination of WAP and FNIII repeats, expressed in complementary domains, with anosmin-1, the product of theANOS1gene, identified as the causative of KS. In the present study, we have investigated the effects of olfactorinin vitroandin vivomodels. The results show that olfactorin exerts an anosmin-1-like strong chemoattractant effect on mouse-immortalized GnRH neurons (GN11 cells) through the activation of the FGFR and MAPK pathways.In silicoanalysis of olfactorin and anosmin-1 reveals a satisfactory similarity at the N-terminal region for the overall arrangement of corresponding WAP and FNIII domains and marked similarities between WAP domains’ binding modes of interaction with the resolved FGFR1–FGF2 complex. Finally,in vivoexperiments show that the down-modulation of the zebrafishz-umodl1gene (orthologous ofUMODL1) in both GnRH3:GFP andomp2k:gap-CFPrw034transgenic zebrafish strains leads to a clear disorganization and altered fasciculation of the neurites of GnRH3:GFP neurons crossing at the anterior commissure and a significant increase in olfactory CFP + fibers with altered trajectory. Thus, our study shows olfactorin as an additional factor involved in the development of olfactory and GnRH systems and proposesUMODL1as a gene worthy of diagnostic investigation in KS.