bluuebunny/crossref_metadata_2025 huggingface dataset:
Arte contemporânea em diálogo com a tradição visual: Cardoso, Zocchio e Navas (São Paulo, 1887-2016)
Authors: MENDES RICARDO
Published: February 2020

RESUMO Estruturado em três segmentos, o artigo comenta em um primeiro momento ensaios visuais dos artistas contemporâneos Patrícia Cardoso, Marcelo Zocchio e Thiago Navas que tomam a cidade de São Paulo e suas representações como questão, em ações que tensionam aspectos como memória, autoria, autoridade e tradição visual. Em seguida, é apresentado um percurso historiográfico sobre a obra de Militão Augusto de Azevedo (Rio de Janeiro, 1837-São Paulo, 1905), produtor visual em destaque na reflexão operada naqueles ensaios. Surge ali como referência em diferentes graus e modos o Álbum comparativo da cidade de S. Paulo (1862-1887), o mais extenso conjunto imagético sobre a cidade ao final da década de 1880. Busca-se destacar como as imagens de Militão foram percebidas e mobilizadas no processo de construção de uma memória urbana local ao longo do século XX e, por fim, na própria constituição do campo da história da fotografia brasileira. O artigo retorna ao final à análise dos ensaios de Cardoso, Zocchio e Navas, comentando como operam sobre princípios estruturais como o recurso comparativo entre fotografias, as funções documentais, representacionais, etc. O artigo enfoca especialmente as temporalidades articuladas pela narrativas imagéticas no álbum de Militão e nas apropriações posteriores, e como uma potente reflexão sobre esses aspectos se realiza no segmento da arte contemporânea, permitindo expor as dinâmicas que submeteram a iconografia histórica local a agendas diversas.
A vivência do tratamento de tuberculose em unidades de Saúde da Família
Authors: Linhares Shirley Ribeiro dos Santos , Paz Elisabete Pimenta Araújo
Published: February 2020

RESUMO Objetivo Compreender a vivência dos portadores de tuberculose referente aos cuidados recebidos durante o tratamento e sua relação com os profissionais de saúde. Método Pesquisa fenomenológica realizada com 27 portadores de tuberculose em unidades de Estratégia de Saúde da Família do município do Rio de Janeiro. Os dados foram obtidos por meio de entrevistas analisadas pelo referencial Heideggeriano. Resultados A análise evidenciou que os usuários estão dispostos no modo de ser da inautenticidade característica dos serviços de saúde; o temor existencial da morte domina o cotidiano dos doentes e os mantêm seguindo o tratamento. Considerações finais e implicações para a prática Existe a possibilidade de se efetivar um cuidado que integre o conhecimento técnico capaz de dominar o modo de ser dos profissionais na dimensão subjetiva de quem precisa do tratamento, superando a tradição ôntica do cuidado inautêntico para o cuidado autêntico, que libera o outro para a cura.
REVISTA BRASILEIRA, DIRIGIDA POR JOSÉ VERÍSSIMO – MOTOR DE UMA GERAÇÃO*
Authors: Bertol Rachel
Published: February 2020

O estudo aborda o projeto editorial da Revista Brasileira em sua terceira fase (1895-1899), levando em conta seus aspectos materiais, como o fato de ter sido financiada por uma sociedade anônima (algo não contemplado em sua bibliografia). Dirigida pelo crítico literário José Veríssimo como uma plataforma eclética de ideias, a Revista correspondeu aos anseios de autonomia dos intelectuais (que botaram de lado a política para convergir na divergência). Assim, fundaram a Academia Brasileira de Letras a partir da publicação, cuja proposta editorial espelhou, ainda, o projeto literário que Veríssimo compartilhava com Machado de Assis: brasileira, mas não nacionalista, pretendia-se cosmopolita, em diálogo não reverente com literaturas e tradições editoriais do exterior. O objetivo era criar um movimento que desse relevância intelectual ao Brasil. Aponta-se para a importância de se observar a imprensa de então em suas esferas transnacionais, e a crítica nos circuitos da rede discursiva.
RESPIRATORY AND SYMPTOMATIC IMPACT OF ASCITES RELIEF BY PARACENTESIS IN PATIENTS WITH HEPATIC CIRRHOSIS
Authors: WITTMER Verônica Lourenço , LIMA Rozy Tozetti , MAIA Michele Coutinho , DUARTE Halina , PARO Flávia Marini
Published: February 2020

ABSTRACT BACKGROUND: Liver cirrhosis is a highly prevalent disease that, at an advanced stage, usually causes ascites and associated respiratory changes. However, there are few studies evaluating and quantifying the impact of ascites and its relief through paracentesis on lung function and symptoms such as fatigue and dyspnea in cirrhotic patients. OBJECTIVE: To assess and quantify the impact of acute reduction of ascitic volume on respiratory parameters, fatigue and dyspnea symptoms in patients with hepatic cirrhosis, as well as to investigate possible correlations between these parameters. METHODS: Thirty patients with hepatic cirrhosis and ascites who underwent the following pre and post paracentesis evaluations: vital signs, respiratory pattern, thoracoabdominal mobility (cirtometry), pulmonary function (ventilometry), degree of dyspnea (numerical scale) and fatigue level (visual analog scale). RESULTS: There was a higher prevalence of patients classified as CHILD B and the mean MELD score was 14.73±5.75. The comparison of pre and post paracentesis parameters evidenced after paracentesis: increase of predominantly abdominal breathing pattern, improvement of ventilatory variables, increase of the differences obtained in axillary and abdominal cirtometry, reduction of dyspnea and fatigue level, blood pressure reduction and increased peripheral oxygen saturation. Positive correlations found: xiphoid with axillary cirtometry, degree of dyspnea with fatigue level, tidal volume with minute volume, Child “C” with higher MELD score, volume drained in paracentesis with higher MELD score and with Child “C”. We also observed a negative correlation between tidal volume and respiratory rate. CONCLUSION: Since ascites drainage in patients with liver cirrhosis improves pulmonary volumes and thoracic expansion as well as reduces symptoms such as fatigue and dyspnea, we can conclude that ascites have a negative respiratory and symptomatological impact in these patients.
EL POTENCIAL DESARROLLO DEL NUEVO PROCEDIMIENTO CONSULTIVO ANTE EL TRIBUNAL EUROPEO DE DERECHOS HUMANOS: FORTALEZAS, DEBILIDADES, OPORTUNIDADES Y AMENAZAS
Authors: Castro Sánchez Yaelle
Published: February 2020

El Protocolo núm. 16 del Convenio Europeo de Derechos Humanos, que entró en vigor el 1 de agosto de 2018 respecto de los Estados que lo han ratificado, establece la posibilidad para las altas jurisdicciones nacionales de los Estados parte en el mismo de solicitar opiniones consultivas al TEDH sobre cuestiones de principio relativas a la interpretación o a la aplicación de los derechos y libertades definidos por el CEDH o sus Protocolos. Ante los desarrollos recientes, nos hemos planteado valorar el particular potencial que tiene este nuevo procedimiento consultivo para garantizar la pervivencia del sistema europeo de protección de derechos humanos a futuro. Para ello, se ha procedido al examen de su contexto, que no es otro que el proceso de reforma del sistema del CEDH, y de sus elementos más significativos en tanto que procedimiento consultivo de reenvío judicial. Como resultado de este análisis se han identificado las fortalezas y oportunidades con las que cuenta para la consecución de sus objetivos, así como las debilidades y amenazas que acechan y que pueden incidir negativamente en la eficacia del sistema a largo plazo, lo que exige permanecer vigilantes para, en su caso, adoptar medidas correctivas apropiadas.
New chemiphotobleaching protocol for Raman spectroscopy v1
Authors: Yakubovskaya Elena , Zaliznyak Tatiana , Martinez Martinez Joaquin , T Taylor Gordon
Published: February 2020

We present a new and simple chemiphotobleaching method to irreversibly suppress background fluorescence of biological specimens during sample preparation for Raman microspectroscopic analysis. Our method combines mild hydrogen peroxide oxidation with broad spectrum visible light irradiation of the entire specimen. We show that >99% of the entire sample’s background fluorescence is eliminated after simultaneous exposure to a low concentration of hydrogen peroxide (3%) and irradiation by a standard photodiode lamp for 0.5–2hours.This treatment permits observing intracellular distributions of macromolecular pools, isotopic tracers, and even viral propagation within cells previously not amenable to Raman microspectroscopic examination.
Aristotelian Rhetorical Theory as a Framework for Analyzing Advertising Texts in the Print Media in Ghana
Authors: Torto Richard T.
Published: February 2020

Advertisements are fashioned in diverse forms, but in most of them, language is absolutely essential. Although visual images, graphic and color designs and other techniques constitute aspects of print advertising, it is the language of the advertisement that enables consumers to identify a product and remember it. Indeed, language has a powerful influence on readers and their behavioral patterns. The English Language is employed in the print media in Ghana as a means of communicating information about goods and services with the goal of persuading the consuming public to take purchasing decisions. In the current article, I applied Aristotle’s Rhetorical Theory to the analysis of persuasive elements in the English used in advertisements in Ghanaian newspapers. The qualitative research design was employed in the study as the corpus was solely from written documents. The findings of the study demonstrated that copywriters in the Ghanaian print media employed Aristotle’s three artistic proofs, namely, logos, pathos and ethos in the English of advertisements for persuasive effect.
Personality Analysis in “A Question of Integrity” —We Are on the Journey to Integrity
Authors: Li Zhouyan
Published: February 2020

Integrity is the foundation of one’s personality. Life is just a question of integrity, and we are on the journey to integrity. Family plays a very important role in the process of personality formation, and personality defects can be healed if you can recognize and accept them, understand the roots of family influence and believe something can be done to improve it until it is integrated. In the novel of “A Question of Integrity”, by analyzing personality defects, tracing family influence, and finding out how to be integrated of the main characters --Alice, Lewis and Nicholas, this paper highlights us to realize that the best way to integrity is to be true to yourself, facing the reality courageously and fighting the difficulties. So we need to guard our integrity as a sacred thing.
Sport Development Index of Banyumas Regency
Authors: N Ngadiman , Kusuma Indra Jati , Festiawan Rifqi
Published: February 2020

The purpose of this study was to evaluate the local government’s success in its development, especially in the field of sports from the aspect of open space availability, community participation, sport resource, and community fitness level (Sport Development Index). Therefore, an evaluative research approach was employed in this study. The research employed both stratified random sampling and cluster sampling techniques. The population basic characteristics included the differences of regional progress level, gender between male and female, age ranging from children aged 7-12 year old, adolescents aged 13-17 year old, and adults aged 18-40 year old, while the basic cluster characteristics used were district and sub-district or village. The research results showed that the open space index was classified in low category (0.180), human resource index in medium category (0.551), public participation index in medium category (0.572), and physical fitness index in low category (0.488). Simultaneously, the Sport Development Index of Banyumas Regency in 2010 is classified in low category (0.487).
Analyzing Social Networks of Destructive Behaviours in Universities/Analizando las redes sociales de comportamientos destructivos en las universidades
Authors: Spanou Kyriaki , Bekiari Alexandra
Published: February 2020

AbstractThe aim consists in presenting determinants and types of verbal aggressiveness, bullying and Machiavellian behaviour among Physical Education students. Twelve network samples were collected from four Greek departments (538 students). Network questionnaires were used. Visone software was used for calculating network variables (in/outdegree, Katz, pagerank, authority). Spearman and PCA have been implemented for relating non-network variables with network ones. Results: Travelling abroad for athletic reasons, surfing internet for studies and being inspired from others’ behaviours trigger disruptive behaviours. Mothers’ education level, economic state, surfing internet for entertainment encourage victimization. Students who have experienced these detrimental behaviours as victims or victimizers during school years continue to experience destructive behaviours during academic years showing that such negative behaviours are adopted.Keywords: Verbal Aggressiveness; Bullying; Machiavellianism; Social Network Analysis; University students ResumenEl objetivo consiste en presentar los determinantes y tipos de agresión verbal, intimidación y comportamiento maquiavélico entre los estudiantes de Educación Física. Se recogieron doce muestras de red de cuatro departamentos griegos (538 estudiantes). Se utilizaron cuestionarios de red. El software de Visone se utilizó para calcular las variables de red (entrada / salida, Katz, pagerank, autoridad). Spearman y PCA se han implementado para relacionar variables que no son de red con las de red. Resultados: viajar al extranjero por razones deportivas, navegar por Internet para estudiar e inspirarse en los comportamientos de comportamiento disruptivo de los demás. El nivel de educación de las madres, el estado económico, navegar por Internet para entretenerse fomentan la victimización. Los estudiantes que han experimentado estos comportamientos perjudiciales como víctimas o victimarios durante los años escolares continúan experimentando comportamientos destructivos durante los años académicos, lo que demuestra que se adoptan tales comportamientos negativos.Palabras clave: agresividad verbal; Intimidación Maquiavelismo; Análisis de redes sociales; Estudiantes universitarios
Re-Conceptualizing Safety of Journalists in Bangladesh
Authors: Hasan Mubashar , Wadud Mushfique
Published: February 2020

Journalists are currently facing a multitude of threats. Commonly, these are considered in terms of harassment and bodily harms such as incarceration and murder of journalists. In the Bangladeshi case we argue that the parameters for evaluating what constitutes safety for journalists go beyond conventional wisdom. On the basis of in-depth interviews of 23 Bangladeshi journalists, we argue that the concept of journalists’ safety has three intertwined dimensions. First, journalists’ safety incorporates avoiding bodily harm (imprisonment, enforced disappearance, and so forth), and harassment, as well as economic and career threats. Second, in order to remain safe, journalists undertake various tactics including compromising the objectivity of news in a regime where security apparatus and pro-government journalists work in tandem to surveil and intimidate non-partisan journalists. Third, the tactics used by journalists decrease public faith in the media and the media can no longer play a watchdog role. We argue that one needs to reconceptualize the safety of journalists within these three intertwined dimensions.
Female Journalists’ Experience of Online Harassment: A Case Study of Nepal
Authors: Koirala Samiksha
Published: February 2020

This study examines the experiences of female journalists in Nepal in the context of rapidly growing expansion of broadband Internet. By examining the findings of the qualitative in-depth interview of 48 female journalists, it argues that online platforms are threatening press freedom in Nepal, mainly by silencing female journalists. The study also indicates that the problem is particularly severe in such a patriarchal society as a significant number of incidents of abuse go unreported, largely due to a culture of shame as well as ineffective legislation. Over the course of this article, I have attempted to show how social issues raised by second-wave feminism and online feminism are similar. The findings show that some of the female journalists experiencing harassment tolerate it by being ‘strong like a man,’ while many of them avoid social media platforms such as Twitter and Facebook to keep free of such abuse. The study also suggests that individual efforts to tackle the vicious issue of misogyny might not be enough and collective effort from legislation, media organisations, and feminists is required to address the issue.
RESEARCH OF STRUCTURAL ORGANIZATION OF THE PERSONALITY OF MILITARY SERVICE CIRCULAR TO ALCOHOL ABUSE IN THE CONTEXT OF THEIR GENDER-ROLE STATUS
Authors: Mozgovyi V.
Published: February 2020

The article deals with the features of the structural organization of the personality of the servicemen who are prone to alcohol abuse. Determined the further focus of the psychologist's part with this category of persons, depending on the identified sex-role status of servicemen who are prone to alcohol abuse. According to the purpose the following tasks have been set: To investigate the specifics of the factor structure of servicemen who are prone to alcohol abuse; Identify the main pivotal features of their psychological portrait; To outline the main ways of psycho-corrective work with the personnel, who are prone to alcohol abuse depending on sexual role status. In total, 64 servicemen of the State Special Transport Service (MoDST) of the Ministry of Defense of Ukraine participated in the study. Research methods are: Prognosis, SZCh-4, HADS, CP-10, Kettel's personal questionnaire, Shmishek's test, self-esteem questionnaire, S. Bem method (determination of level of masculinity / femininity assessment) and structural gender-role scale (A. Kocharyan – EV Frolova), as well as Dur-Moll (masculinity-femininity, respectively) by S. Sondi's method. The study revealed the character traits of a psychological portrait of servicemen who are prone to alcohol abuse: excitability, cyclothymia, anxiety, non-conformism and abusive behavior. The following key core personality indicators have been identified such as neuropsychiatric resistance, risk of nerve failure, and personal readiness to use inverted dynamics weapons. The focus of psycho-corrective influence of part of the psychologist on the personality of alcohol addicted servicemen should be to conduct training sessions aimed at forming a positive image of the serviceman.
PSYCHOLOGICAL FEATURES OF PEOPLE WITH BORDERLINE PERSONALITY DISORDERS
Authors: Morozova V.
Published: February 2020

The article presents the results of an empirical study of the psychological features of people with signs of borderline personality disorder. The study involved 40 people with signs of borderline personality disorder aged 14-56 years. According to the purpose of the study, the following tasks have been set: To investigate personality with borderline disorder; Identify and evaluate the neurotic states of a person with a borderline personality disorder; Conduct correlation analysis to investigate trends in the relationship between the indicator of the number of signs of borderline disorder and personal characteristics. The following research methods were used: 5PFQ Big Five technique (R. McCray, P. Costa), Clinical questionnaire for the detection and evaluation of neurotic conditions (KK Yakhin, DM Mendelevich) and Methods for diagnosing borderline personality disorder (TY Lasovskaya, CP Korolenko, SV Yaechnikov). The data obtained were subjected to a mathematical and statistical analysis procedure using the SPSS Statistic program. It is proved that emotional lability (instability of emotions), impulsiveness and self-harming behavior are important diagnostic criteria of a borderline personality disorder. High level of manifestation of signs of borderline personality disorder is accompanied by such mental states of disadaptation as neurotic depression, asthenia, tension and anxiety.
FEATURES OF PSYCHOLOGICAL PREPARATION OF FUTURE DEVELOPMENT WORKERS TO PROFESSIONAL ACTIVITY
Authors: Ligotskyi Anatoliy
Published: February 2020

The article explores the problem of conceptualization of cognitive-communicative and information-semiotic dimensions of psychological preparation of future social workers for professional activity as a complex psychic formation between components of which there are stable functional dependencies.

The article analyzes psychological literature on the problem of the use of special psychological knowledge in the activities of a social worker. The problems of interrelation of application of special psychological knowledge in the activity of social worker, regularities and peculiarities of attraction of the indicated knowledge at different stages of professional activity are analyzed, as well as problems of professional training of social work specialists who can provide psychological and social assistance to different categories of citizens who are staying in difficult life circumstances, which is becoming increasingly urgent in today's society.

Thus, the personality of the social worker determines the state of the social sphere of the state, from the vocational training, a broad outlook, the level of culture and civic position which directly depend on the results of social development of society. The main criterion for the assessment of a graduate of a higher education institution is competence, while the determining factor for the success of his professional activity is the formation, integrity of his personality, spiritual wealth, moral and aesthetic image, but it is not enough for the psychological knowledge and understanding of the students sphere. This is what ensures a high level of social activities, their objectivity to specific activities, mental phenomena, states and processes.
CRISIS INTERVENTION IN THE CASE OF PSYCHOTRAUMATIC SITUATION
Authors: Norkina Iryna
Published: February 2020

The article deals with the questions of the psychologist's activity regarding assistance to the person in crisis. The basics of the theory of crisis intervention are outlined, the concept of crisis is operationalized and criteria for distinguishing between the concepts of micro trauma and micro trauma are introduced. The conceptual apparatus of the approach is developed in detail and the necessity of its unified understanding by practical psychologists is substantiated. The purpose of the article is to analyze the process of crisis intervention in the activity of the psychological service (psychologist), which takes measures to resolve the traumatic situation and reduce its impact on human life. An important factor in crisis intervention is the psychologist's understanding of the nature of the crisis, the severity and mechanisms of its experience. An important place is given to the stages of personal response, which determines the strategy and directions of professional intervention. Analyzing the process of crisis intervention in the activities of a psychologist (psychological service) identified important tasks that should be implemented: 1) the removal of symptoms; 2) recovery to crisis level of functioning; 3) awareness of those events that lead to an imbalance; 4) identify the internal resources of the client and family in various forms of crisis management assistance. The theoretical and practical recommendations given are outlined by the use of the voyage method, based on the real case of a crisis situation, which led to psychological trauma in participants and witnesses. As the above case is related to a terrorist act, the article also provides theoretical and methodological information regarding the specificity of the work of a psychologist with the concept of terrorism and the peculiarities of its impact on participants and witnesses of such acts. Based on the results of the case study, the author formulated practical recommendations for practicing psychologists on what to consider when dealing with an injury, especially if it was caused by an act of terrorism. The article concludes with the need to take into account the emotional reactions of a person to a crisis and the long-term changes in their ability to withstand daily problems. Crucial in dealing with clients is given to the psychological conditions that are discussed in detail in the article.
PROCEDURE OF SEMANTIC-SENSE ANALYSIS OF THE RESEARCH OF THE DEVELOPMENT OF AKME-ORIENTED MATURE PERSONALITY
Authors: Tkachenko Oleksandr
Published: February 2020

The development of a mature personality is considered in the context of its holistic and purposeful presentation in the form of a generalized category of the work of life and an acme-oriented mature personality, as an integrative-holistic entity. This education is systematically structured on the basis of the Axi-vector of higher values at the pre-reflexive, reflective and spiritual levels and the acme vector according to the stages of acme orientation. The article presents the procedure of the semantic-sense analysis of the research of the development of akme-oriented mature

personality. The following experimental procedure for semantic-sense analysis of narratives is presented. 1) Semantic analysis, which allows to identify the "semantic field" (SF) and form a "concentration sense" (CS). 2) Correlation analysis, which makes it possible to single out the "common semantic core" (CSC), to determine the correlation coefficient, as well as the "coincidence" of identical words. 3) Sense analysis, which envisages the creation of a "common concentrated sense" (CCS) and a "specific concentrated sense" (SCS), which was used in the study of the development and formation of the model acme-oriented mature personality (AOMP).

The article deals with the procedure of semantic-semantic analysis on the example of one of the most stressful situations (the first battle) of combat operations (DB) under counter-terrorism operation (ATO), when the focus is on axiological meanings. The proposed procedure for semantic-semantic analysis of narratives is an effective tool that consists of standardized techniques that are valid and reliable. Also, the complex application of these methods, and thanks to individual generalization with the help of a competent expert, can produce a qualitatively new result in the form of axiological meanings. This makes it possible to conduct an experimental procedure in combat and is, in turn, an effective tool for psychological research in crisis situations. Therefore, the results presented in the article are an achievement that is of practical importance, both for peer review and for the purpose of psychotherapy.
LEGAL INSTITUTIONAL FRAMEWORK FOR SPECIAL ECONOMIC ZONES IN LATVIA
Authors: Ezmale Sandra
Published: February 2020

The regulatory framework of the freeports and special economic zones of Latvia are analysed in the paper providing as well an insight into the changes related to granting aid that have taken place. There are five freeports and special economic zones in Latvia, though, while the conditions for granting the aid are the same, the way they operate varies. The research aims to describe the institutional framework of special economic zones in Latvia. The author (1) has carried out a study on scope and conditions for granting the aid in the freeports and special economic zones of Latvia; (2) has described the restrictions on granting the aid. The monographic research and comparative analyses methods are used in the research.
GENERATION Z ENTERS INTO THE LATVIAN BUSINESS ENVIRONMENT
Authors: Silinevica Irena , Meirule Laila
Published: February 2020

There are five different generations in the Latvian labour market. Each generation has its own values and life experience. Recent research has shown that generation Z entering the labour market is significantly different from previous generations. They have different approaches when it comes to purchasing, choosing a career, working attitude, and so on. Therefore, research is needed to understand what changes this generation will bring to the business environment in the years to come. The aim of this  research study is to investigate some of the different aspects of generation Z behaviour in the labour market.  This research study includes theoretical and empirical parts. Findings of various theoretical studies on distinctive values and attitudes of generation Z have been investigated. The empirical study compares the values of different generations and highlights the differences between the generations in the labour market. Recommendations are made for successful integration of generation Z into the business environment.
Severe Cutaneous Adverse Reactions to Drugs in Latin America: The RACGRAD Study
Authors: Rojas Mejía DV , Zwiener RD , Cardona Villa R , Ramírez LF , Silva Espinosa DL , Zanacchi VA , Piraino Sosa P , Ensina LF , Giavina Bianchi P , Coelho Portilho N , Vivolo Aún M , Matos Benavides E , Martínez Ruíz DM , Jares E , Serrano Reyes CD
Published: February 2020

Background: Severe cutaneous adverse reactions to drugs (SCARs) are associated with high morbidity and mortality and with sequelae. Objective: To characterize patients with SCARs in 8 health care institutions in Latin America. Methods: We performed a cross-sectional, descriptive, multicenter study of patients diagnosed with SCARs in Latin America between January 2009 and December 2018. The analysis was carried out using a database in BD Clinic. Results: We collected 70 patients, of whom 42 (60%) were women. Mean age was 38.7 years. Forty-two patients (60%) had DRESS-DIHS, 12 (17.1%) TEN, 5 (7.1%) SJS, 6 (8.5%) AGEP, 4 (5.7%) other reactions not classified as SCARs, and 1 (1.4%) overlapping SJS-TEN. The main causative drugs were aromatic anticonvulsants in 31 cases (44.3%), ß-lactam antibiotics in 11 cases (15.7%), and non–ß-lactam antibiotics in 6 cases (8.6%). In all of the cases, the suspected drug was withdrawn at the first sign of a SCAR. Sixty-six patients (94.2%) received anti-inflammatory treatment, mostly systemic corticosteroids. Complications occurred in 53 cases (75.7%), and 3 patients died (4.3%). Thirteen patients (18.6%) had sequelae. Conclusions: This is the first multicenter report on SCARs in Latin America. DRESS-DIHS was the most frequently reported clinical entity, and anticonvulsants were the main triggers. Most of the patients received systemic corticosteroids. Complications were frequent, and 3 patients died.
Effect of Aegle marmelos methanolic extracts of leaf and fruit pulp on learning and memory in albino rats
Authors: Kumar Pojala , K. Krishnakanth , Alla Jagadeesh
Published: February 2020

Background: The objective was to study the effect of Aegle marmelos methanolic extracts of leaf (LE) and fruit pulp extract (FE) on learning and memory in albino rats. 40 healthy wistar albino rats of either sex were randomly divided into 10 groups of 4 each (n=4), weighing about 150 to 200 gm were selected for the study. The extracts i.e. 1ml of 1% carboxy methyl cellulose, LE and FE at doses of 100 mg/kg and 200 mg/kg were administered per oral one hour before the experiment.Methods: Learning and memory was assessed by elevated plus maze and Hebb William maze. Latency time and number of entries were assessed by elevated plus maze whereas only latency was assessed by Hebb William maze.Results: Plant extracts of LE and FE at doses 100 mg/kg and 200 mg/kg have shown significant percentage reduction in latency time in elevated plus maze and Hebb William maze (p<0.05) and reduction in the number of entries in elevated plus maze.Conclusions: LE and FE at doses 200 mg/kg have shown significant effect on learning and memory.
Antinociceptive effect of methanolic extract of Murraya koenigii leaves in swiss albino mice
Authors: J. Arunkumar , M. Vijayalakshmi , S. Yesodha , A. S. YousufAli , R. Parthiban
Published: February 2020

Background: The objective of the study was to evaluate anti-nociceptive effect of methanolic extract of Murraya koenigii leaves on thermal and mechanical pain in swiss albino mice.Methods: Thirty adult male swiss albino mice weighing 25-30 grams were selected and allocated in to five groups. Each group consists of six animals. The control group received vehicle (10 ml/kg), standard group received morphine (10 mg/kg) and test groups received dried methanolic extract of Murraya koenigii leaves (100 mg/kg, 200 mg/kg, 400 mg/kg per oral respectively) 1 hour before placing the animal over the hot plate at temperature of 55⁰C . A cut off period of 10 sec was observed to avoid damage of the paw. The response in the form of withdrawal of paws or licking of the paws. The delay in the reaction time denotes analgesic activity. The latency was recorded before and after 15, 30, 60, 120 minutes administration of drug. After washout period of 1 month the same group of animals were utilized to evaluate the analgesic effect by tail clip method for better comparison.Results: All the doses of Murraya koenigii leaves significantly delayed reaction time in hot plate method and tail clip method. The results were comparable to that produced by standard drug morphine.Conclusions: Murraya koenigii leaves has analgesic activity which was comparable to morphine.
A study of pattern of vitamin D deficiency in newborns with reference to its gestational age and birth weight
Authors: Narayan Raghvendra , Singh Shivani , Singh Om Prakash
Published: February 2020

Background: Deficiency of Vitamin D is a prominent health problem globally and its severity is significant in countries like India regardless of age, gender, race and geographical distribution. It is presently the most untreated nutritional deficiency worldwide. Vitamin D during pregnancy has an increasingly recognized range of functions such as  immune modulation, lung development etc. Hence, having the potential to  influence many factors in the developing fetus. Effects of vitamin D deficiency on fetal health is abundant; some being for brief period  of  time  and others may become apparent in later life. Objectives of this study the pattern of vitamin D deficiency in newborns with reference to its gestational age and birth weight.Methods: This was a hospital-based prospective observational study. Total 100 neonates born at MMIMSR, Ambala were enrolled out of which 50 were term and 50 preterm.Results: Out of 100 newborns delivered, 53 newborns were vitamin D deficient. Premature  newborns having 32 (60%) and term newborn having 21 (40%) were found to be deficient in vitamin D. Mean 25 (OH) levels were 21.81 ng/dl.Conclusions: More than half newborns were deficient in vitamin D. Premature newborns had relatively low levels as compared to the term newborns and the  difference  between  two were found  statistically significant.
Third trimester maternal blood and at birth cord blood lipid profile characteristics in pregnant woman with or without fetal growth restriction
Authors: Nayan Swati , Meena Mohan , Rajoria Lata , Hooja Nupur , Gothwal Sunil , Fatima Andleeb , Meena B. S. , Bairwa Ghan Shyam , Meena Priyanka , Nawal Rajni , Sharma Megha
Published: February 2020

Background: To study the lipid profile of 3rd trimester pregnant women and their cord blood with and without intrauterine growth restriction Design: Observational study, Setting: Department of Obstetrics and Neonatology, in a teaching hospital in North India during February 2013 to August 2014.Methods: Third trimester pregnant women and their neonates. Enrolled 250 women were divided in intrauterine growth restricted and control groups. Outcome Measures: Venous blood Lipid levels of 3rd trimester mothers and their neonate at birth.Results: Women of IUGR group had significantly lowered total cholesterol (TC), triglycerides (TG), high density lipoproteins (HDL) and low density lipoproteins (LDL)210.2 (19.8), 221.6 (36.2),65.4(11.7)and 130.7 (20.8)compared to 251(55.3), 234.7(35.6), 70.8(19.9) and 181.3(16.8) mg/dl control group. The TC, TG and LDL levels in cord blood of IUGR group were 93.6(16.5), 50.4 (6.5) and 51.8(12.6) as compared 106.4(17.7), 30.7(4.4) and 55.9(12.1) mg/dl to control group (p value <0.05). HDL levels were significantly lower 15.8(4.6) in IUGR group as compared to 26.5(5.4) in control group. The LDL: HDL and TC: HDL ratio was significantly higher in IUGR group. Maternal weight, gestational age, urban residence, primi parity, birth weight and APGAR score were lower, while maternal age, parity, smoking, blood pressure, cesarean sections (%) and male sex (%) of baby was higher in IUGR group.Conclusions: Lipid profile of mothers of IUGR fetuses had significantly lowered cholesterol levels and their cord blood had shown atherogenic phenotype
Clinical and laboratory profile of children with dengue fever admitted at a tertiary care hospital in Mangalore, Karnataka, India: a retrospective study
Authors: M. Tejaswini , S. Sahana K. , Saldanha Prakash R. M.
Published: February 2020

Background: Dengue fever caused by dengue virus is a self-limiting acute febrile illness transmitted by Aedes aegypti, a daytime biting mosquito. Dengue virus belongs to family of Flaviviridae and there are 4 serotypes. A fifth serotype DENV-5 was isolated in 2013 which was said to cause mild form of the disease. In 2019 total numbers of dengue cases are 10,524 in Karnataka which is 138% increase over 2018 (4,427 cases).Methods: A retrospective conducted in Yenepoya Medical College hospital from January 2017 to July 2019 for a period of 2½ years. Medical records of children who were diagnosed with dengue fever were retrieved and analyzed. Clinical and laboratory findings were noted down. Clinical course and outcome were noted down from the case sheet and cases were classified as per WHO 2011 classification.Results: 97 children diagnosed with dengue fever were included in the study. Common age group was 5-15 years. 49.5% had dengue fever, 40.2% had dengue haemorrhagic fever (DHF) and 10.3% had expanded dengue syndrome. Fever was the main complaint. Children with dengue fever presented with vomiting, abdominal pain, myalgia, arthralgia in descending order of frequency. Children with DHF, petechiae were seen in 38% patients. Among bleeding manifestations, epistaxis was more common. Children with expanded dengue syndrome had atypical manifestations.Conclusions: Dengue fever like any other viral illness, presents with prodromal symptoms which should be picked up at the earliest with high index of suspicion in children coming from endemic area. Identification of atypical manifestations and co-infections at the earliest and prompt treatment avoids serious life-threatening complications.
Prevalence and risk factors for anxiety and depression among school going adolescent of Rajkot, Gujarat, India
Authors: Patel Dipal , Patel Dhara
Published: February 2020

Background: Adolescence is a period of turmoil, leading to several mental health challenges including anxiety and/or depression. Anxiety and depressive disorders affects 10-15% of adolescents. Anxiety and depression are associated with substantial negative effects on adolescent’s social, emotional and academic success. This leads to poor social and coping skills, low self-esteem, perceptions of social rejection, and difficulty forming friendships. This study was carried out with an objective to study prevalence and risk factors for anxiety and depression among adolescents.Methods: A cross sectional study conducted from April 2014 to December 2015 among 1026 school going adolescents from 4 schools of Rajkot, Gujarat, India. Anxiety and depression were measured using Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) respectively. Chi-square test was applied as test of significance.Results: Majority of the students (58.1%) was belonged to early adolescent age group. Two third were males. Maximum adolescents (42.5%) were coming from class III. Prevalence of moderate-severe anxiety and depression was 9.9% and 18.5%. Anxiety was not significantly associated with age, gender and socio economic class. Prevalence of depression was significantly higher in boys (20.5%) as compared to girls (14.5%, p=0.02). Moderate to severe depression was gradually increased with increasing in age. Adolescent from upper socio economic class (I, II, III- 19.1%) were severely depressed than adolescent from lower socio economic class (IV, V- 4.1%).Conclusions: Anxiety and depression was significantly present in adolescent age group. Depression was commonly observed in boys and gradually increased with increasing in age. There is need of strengthening school health services with screening and cost effective interventions to minimize the risk of drug abuse, suicide and violence.
Immune reconstitution inflammatory syndrome in non human immunodeficiency viruses children on anti tubercular treatment
Authors: V. Archana , M. Shafath Ahamed , S. Sundari
Published: February 2020

The term IRIS is almost solely used in human immunodeficiency virus seropositive patients who initiated anti-retroviral therapy (ART), the term paradoxical reaction is generally used to describe a clinical worsening of tuberculosis disease after the initiation of antituberculosis treatment. Distinguishing this paradoxical reaction (PR) from disease progression or treatment failure is an important issue in CNS tuberculosis management. Thus, one must keep a watch for neurological deterioration in a child with Central nervous system tuberculosis (CNS TB). We are presenting a case of a non-Human immunodeficiency virus (HIV) child who developed TB-IRIS while on anti-tubercular drugs, who subsequently responded to steroids along with continuation of antitubercular treatment (ATT).
Ileal duplication cyst: a rare cause of intestinal obstruction in infants
Authors: Basak Aniruddha , Ghosh Arindam , Mishra Prafulla Kumar
Published: February 2020

Ileal duplication cyst (IDC) is a rare congenital anomaly where there is an abnormal portion of intestine attached to or intrinsic with the normal bowel. A 6-month-old male child presented with obstipation and bilious vomiting at emergency. X-ray abdomen showed multiple air fluid level suggestive of intestinal obstruction. Laparotomy was performed. Diagnosis of IDC was made and resection with primary anastomosis was done. Post-operative period was uneventful, and patient did well during 3 month follow-up checkup. IDC is a rare cause of intestinal obstruction which can present with different clinical symptoms posing a diagnostic dilemma. Diagnostic laparotomy is a suitable approach for both diagnosis and treatment to avoid delays in treatment where imaging method is unavailable for exact diagnosis.
Study of impact of clinical and biochemical parameters in aluminium phosphide poisoning
Authors: R. Madhumathi , Durairaj Anugraha
Published: February 2020

Background: The aim of the study was to assess the relationship between clinical and biochemical parameters with outcome of aluminium phosphide toxicity.Methods: Total 46 patients with aluminium phosphide poisoning admitted to the Hospitals attached to BMCRI between November 2018 and April 2019 were prospectively studied. After adequate history was obtained and immediate first aid measures given, clinical and biochemical parameters such as liver enzymes, serum creatinine, serum potassium and magnesium levels were studied. The patients were then followed up until outcome. Data was analysed using Descriptive statistics like mean, Standard deviation and percentages were calculated. Inferential statistics like Mann-Whitney test was used to compare the parameters between the two outcome groups (discharged and death) using SPSS software.Results: Among the study population, between the two outcome groups males were 80.6% and females were 19.4%. the outcome was death in 10 patients and 36 patients were discharged. Tachycardia and hypoxia at presentation, Low Serum Magnesium and higher levels of serum creatinine at admission were found to be associated with higher mortality in patients with aluminum phosphide toxicity and were statistically significant.Conclusions: These clinical and laboratory parameters can be considered as manifestation of hemodynamic compromise and are hence associated with poorer prognosis. Serum magnesium levels, can be used in prognostication of aluminium phosphide toxicity, owing probably to their effects of cardiotoxicity. Increased serum creatinine levels as a result of acute kidney injury, could also indirectly point to circulatory compromise. Hence these clinical and laboratory parameters at presentation have important implications.
Understand the risk factors associated with non alcoholic fatty liver disease and changes in biochemical parameters in the patients: a prospective study
Authors: Shende Atul , Chandra Umesh Kumar , Gowda Dharshan , Warkade Vinay , Ganganpalli Dattaprasad
Published: February 2020

Background: The true prevalence of both NAFLD and NASH are elusive but estimates based on imaging and autopsy studies suggest that about 20-30% of the adults in United States and western countries have excess fat accumulation in the liver. About 10% of these, strictly speaking about 2-3% of the adult population fulfils the criteria of NASH. True prevalence of NAFLD in Indian patients is not known. So, this study was planned to look for current trend of NAFLD in Indian patients.Methods: This prospective observational study was conducted in the Department of Medicine on 65 patients with ultra-sonography finding of fatty liver disease with no history of alcohol, in one year study duration.Results: It is observed that maximum patients are of middle age from age 31-60 years comprising 76% of patients. Out of total patients, 34% and 66% were males and females respectively. Out of 65 patients, 45(69%) had obesity and maximum number of the patients had waist hip ratio and neck circumference more than the cut off value. Out of 65 patients, 19(29%) had hypercholesterolemia and 42(65%) had hyper-triglyceridemia. Out of 65 patients, 32(49%) had higher alanine transaminase (ALT) level and 17(29%) patients had higher AST level. Out of 65 patients, 29(45%) had the homeostasis model assessment of insulin resistance (HOMA-IR) less than cut off value (less than 2.25) and remaining 36(55%) were having HOMA-IR more than 2.25. The sensitivity for the cut off value for HOMA-IR is 72.7% and specificity is 49.1%.Conclusions: Obesity, neck circumference, and waist hip ratio are higher than its cut off value for both sex, insulin resistance evaluated through HOMA- IR  directly relates to the causation of NAFLD but at some extents higher triglyceride levels are also associated but the values of ALT and AST levels did not give any clue in these cases of NAFLD.
Role of insulin-like growth factor 1 in pathogenesis of acne vulgaris: relation to acne severity and body mass index
Authors: Adel Shereen , Abd-El-Raheem Talal A. , Ezzat Ghada , Ismail Nermeen M.
Published: February 2020

Background: Acne vulgaris is a multifactorial skin disease. A potential role for insulin-like growth factor-1 (IGF-1) has been suggested in the pathogenesis of acne. Several studies have shown that elevated levels of serum IGF-1 correlate with overproduction of sebum and acne. Objective: Measurement of the serum level of IGF-1 in acne patients in comparison to normal controls and evaluating the relationship of these levels to severity of acne and body mass index (BMI), in order to investigate the role of this factor in the pathogenesis of acne.

Methods: Fifty-four patients with acne vulagaris and 42 healthy controls were included. History taking, dermatological examination, clinical assessments of acne severity, calculation of BMI were performed for patients. Blood samples were collected from all participants for estimation of serum IGF-1 level using enzyme linked immunosorbant assay.

Results: There was a significantly higher serum IGF-1 level in acne patients (p<0.05) than controls. Authors didn’t find a relation of significance between elevated serum IGF-1 level and degree of acne severity and BMI (p>0.05). There was a significant positive correlation between serum IGF-1 level and age of the patients.

Conclusions: There is a significantly higher serum IGF-1 in acne patients than controls not related to acne severity and BMI. That is adding to the scientific evidence of IGF-1 role in pathogenesis of acne vulgaris.