bluuebunny/crossref_metadata_2025 huggingface dataset:
Group relations, innovation, and the production of nostalgia
Authors: Sapochnik Carlos
Published: July 2020

This article explores the concept of nostalgia from both phenomenal and interpreta-tive perspectives as experienced within and generated by group relations confer-ences and other group activities like sport, drama, or music. It posits that nostalgia inevitably emerges in group relations conferences to sustain primitive fantasies and the work of mourning necessary for psychic growth. The article then reflects on the dual purpose of conference titles as setting objectives to the exploration as well as protection from wild thoughts, enactments, and thus the unmitigated brutality of the experience of the unconscious in groups. It calls attention to how the intention to apply conference learning arises from (and contributes to) an overdetermined ambivalent relationship of group relations with psychoanalysis.
IMPLEMENTASI PERATURAN DAERAH PROVINSI KEPULAUAN RIAU NO.7 TAHUN 2011 TENTANG PELAKSANAAN PENGARUSUTAMAAN GENDER DALAM PEMBANGUNAN DI PROVINSI KEPULAUAN RIAU TERHADAP KESEJAHTERAAN MASYARAKAT DI KOTA TANJUNGPINANG (Studi Kasus pada Dinas Pengelola Keuangan dan Aset Daerah Kota Tanjung Pinang)
Authors: Harun Askarmin
Published: July 2020

This study aimed to analyze the compatibility between the implementation of gender mainstreaming is implemented by the Regional Regulation No. 7 Year 2011. This research was conducted at the Department of Financial Management and Asset (DPKAD) city of Tanjung Pinang. This research was conducted using the case study method. The results of this study shows the implementation of gender mainstreaming in the town of Tanjung Pinang. However, the gender mainstreaming only in activities carried out and is not accompanied by a budget allocation so that gender mainstreaming, not in accordance with Regional Regulation No. 7 Year 2011 on Gender mainstreaming is endorsed by the government.Keyword: implementation regulation, PUG and PPRG Penelitian ini bertujuan untuk menganalisis kesesuaian antara penerapan pengarusutamaan gender yang dilaksanakan dengan Peraturan Daerah No. 7 Tahun 2011. Penelitian ini dilakukan di Departemen Pengelolaan Keuangan dan Aset (DPKAD) Kota Tanjung Pinang. Penelitian ini dilakukan dengan menggunakan metode studi kasus. Hasil penelitian ini menunjukkan implementasi pengarusutamaan gender di kota Tanjung Pinang. Namun, pengarusutamaan gender hanya dalam kegiatan yang dilakukan dan tidak disertai dengan alokasi anggaran sehingga pengarusutamaan gender, tidak sesuai dengan Peraturan Daerah No. 7 Tahun 2011 tentang Pengarusutamaan Gender yang disahkan oleh pemerintah.Kata Kunci: peraturan pelaksanaan, PUG dan PPRG
PEMANFAATAN GOOGLE DRIVE DALAM PENILAIAN MANDIRI PELAKSANAAN REFORMASI BIROKRASI (PMPRB) DI PEMERINTAH PROVINSI KEPULAUAN RIAU
Authors: Harun Askarmin
Published: July 2020

Reformasi 1998 menunjukkan adanya gerakan sosial masyarakat yang mendorong adanya perubahan terhadap krisis multidimensi dalam bidang ekonomi, politik, hukum dan Birokrasi. Perubahan tersebut dilandasi oleh keinginan untuk mewujudkan pemerintahan yang demokratis, bersih dan mempercepat terwujudnya kesejahteraan rakyat. Reformasi pada bidang birokrasi menjadi bagian yang cukup penting dalam upaya mewujudkan pemerintahan yang bersih. Reformasi Birokrasi dapat mewujudkan penyelenggaraan tata kelola Pemerintahan yang baik (good governance), profesional dan berintegritas tinggi baik pada pemerintahan pusat maupun daerah. Penilaian pelaksanaan reformasi birokrasi pada pemerintah daerah adalah bentuk kongkrit penerapan nilai-nilai reformasi birokrasi yang akuntabel dan terukur. Seiring perkembangan zaman yang didorong dengan kemajuan teknologi, pemanfaatan media dapat digunakan sebagai penunjang pelaksanaan reformasi birokrasi. Pemanfaatan media juga dapat membuat pelaksanaan reformasi birokrasi terlaksana secara transparan dan akuntabel.
The application of reader-response theory to teach symbolism in literature class for EFL students
Authors: Kinasih Putri Rindu
Published: July 2020

For years, scholars believed one effective approach that can be used in teaching literature in EFL context is reader-response approach yet very limited study can be found about the application of reader-response theory in teaching symbolism. Whereas, symbolism is considered as the most important elements of serious imaginative literature which provide rich sources of insight. The problem is, deciding exactly what is represented by a symbol is not an easy thing to do, though the general meaning is clear because a symbol most commonly represents something unnamed. This research aimed to find out the application of reader-response theory in teaching symbolism. This research observed 16 participants majoring in English Literature program. Within four weeks, the participants were asked to read selected poems and short stories and asked to write a reflective writing as a response. Then, the writings were assessed by using critical thinking rubric. From this research, it can be drawn that the participants’ score of symbolism interpretation were increasing by the end of the research. In other word, reader-response theory is beneficial to the improvement of students’ inadequacies in studying symbolism and offers potential benefits to solve problems in literature discussion such as low self-confidence and fear of stating out different interpretations. By the end of the research, the participants are more accustomed to express various ideas and more motivated to explore more supporting sentences to strengthen their ideas.
Teaching English: An afresh sophisticated technique to cultivate digital native learners’ vocabulary by utilizing seesaw media as digital literacy
Authors: Riadil Ikrar Genidal
Published: July 2020

In the modern and digital era, digital native’s learners are conceived into an era of digital networking. It keeps everything connected to technology. Digital natives with digital technical expertise and abilities which can theoretically be utilized for improved learners’ interaction in the classroom. The government has began to vigorously increase the literacy culture in schools by doing reading literacy. Teachers will be willing to provide an precedent by developing a community of literacy at school. Increased classroom reading atmosphere also improves vocabulary for learners studying English. The Seesaw Media implementation may also help learners to insert allusions to enhance scientific knowledge as a regulatory framework for learning. The aim of this research was to discern the use of Seesaw as the media of literacy to cultivate learners’ vocabulary. This research pursued to answer two research questions; (1) does Seesaw Media helps learners to improve their reading ability? And (2) what are the impacts of Seesaw Media application on the learners on developing vocabulary? The methods used by the researcher were; firstly, the researcher distributed the questionnaire with the English learner's. Secondly, the researcher assessed the feedback from the respondents. Thirdly, the researcher sought the response to the learners on the effect of reading ability by using Seesaw. This research has used descriptive qualitative to conduct the research study. This result of the research has shown the Seesaw Media helped learners to improve their reading ability.
Erythropoiesis- and Thrombopoiesis-Characterizing Parameters in Adenosine A3 Receptor Knock-Out Mice
Authors: HOFER M. , POSPÍŠIL M. , DUŠEK L. , HOFEROVÁ Z. , WEITEROVÁ L. , KOMŮRKOVÁ D.
Published: July 2020

Influence of the regulatory system mediated by adenosine A3 receptors on the functioning of erythropoiesis and thrombopoiesis was studied by means of evaluation of the numbers and attributes of peripheral blood erythrocytes and platelets, as well as of erythroid bone marrow progenitor cells in adenosine A3 receptor knock-out (Adora3tm1Jbsn/Adora3tm1Jbsn, A3AR(-/-)) mice and their wild-type C57BL/6 counterparts, both males and females. Minor but statistically significant disturbances in the properties of erythrocytes, namely in the parameters of mean erythrocyte volume and mean erythrocyte hemoglobin were observed in A3AR(-/-) mice. In addition, adenosine A3 receptor knock-out mice were found to exhibit an expressive, statistically significant decrease of their blood platelet count, amounting to 17 % and 21 % in males and females, respectively. This decrease in platelet levels was accompanied by a significant 17 % decline in the plateletcrit in both sexes. The obtained data can help to define therapeutic applications based on the principle of adenosine receptor signaling.
AGRICULTURE AND CLIMATE IN CENTRAL OTAGO
Authors: Cossens G.G.
Published: July 2020

The variation and individuality of Central Otago result from a unique combination of climate and topography. The range and basin structures produce New Zealand's nearest approach to a "Continental" Climate, and on a yearly basis Central Otago can be one of the driest as well as one of the hottest and coldest areas in the country. There are two unique features. The first a dry central core wth horticulture as a dominant activity. The second is a high pastoral plateau, the East Otago Plateau, from 400 to 900 metres altitude, marking the Eastern boundary of Central Otago. The agricultural pattern is traditional but it is suggested there is scope for other non traditional crops. Of all the physical elements surveyed in the past, e.g. rock or soil type, slope or vegetation, there is frequently no reference to climate. However, the resource value of any locality draws from its particular local climate or "topoclimate". Climate when regarded as such requires a new approach to data gathering. Research in Central Otago aims to increase our knowledge of topoclimate on the valley floors and locate special microclimates suitable for possible and existing horticultural crops and at the same time remove some of the hazards. Keywords: topoclimate
THE SEARCH FOR AN IMPROVED Lotus pedunculatus FOR HIGH COUNTRY PASTORAL SYSTEMS
Authors: Keoghan J.M. , Burgess R.E.
Published: July 2020

The performance of 55 Lotus pedunculatus lines of diverse type and origin was assessed on acid and infertile soils on the East Otago Plateau at 3 sites representing an altitudinal sequence of increasing severity of climate. Tetraploid lines and lines with Mediterranean parentage were more susceptible to out-of-season frosting than their diploid equivalents and lines without Mediterranean parentage. By the 3rd summer, a diploid NZ selection, G4701, showed a good combination of high herbage yields, rhizome spread and tolerance of frosting at all sites. G4701, its tetraploid equivalent, G4702, and a selection from within the cultivar Grasslands Maku for rapid germination at low termperatures produced the highest yields averaged over the 3 sites in the altitudinal sequence. The use of these lines is likely to enhance the role of lotus in tussock grassland pasture systems. Keywords: Maku, G4701, G4702, low temperature germination, frost damage, rhizome spread, herbage yield.
MANAWATU DAIRY FARMERS EXPERIENCES WITH MATUA PRAIRIE GRASS
Authors: Sellars M.D.
Published: July 2020

Manawatu dairy farmers have been quick to appreciate the possible benefits of a pasture species that can out-perform conventional ryegrass white clover based pastures. A survey conducted by Grasslands Division, DSIR in 1985 showed knowledge and use of Matua praire grass by dairy farmers in the Wellington province were 70% and 42% respectively, compared with the national figures of 55% and 29% for dairy farmers, and 32% and 9% for non-dairy farmers. When Matua was first released little data was available as to how best to sow the seed, what seed mixes are the most appropriate, how to manage the establishing pasture, and how to get the best from an established pasture. Researchers and pioneering farmers right around the country have by trial and error found the answers to most of these questions. The stimulus to find the answers was always the promise that Matua offered, that of 15 to 30% extra drymatter production compared to standard ryegrass pastures. Not only is there more annual drymatter, but the extra comes at very useful times for the dairyfarmer: winter, early spring and late summer.
VARIETIES OF ITALIAN RYEGRASS IN NEW ZEALAND
Authors: Forde M.B. , Burgess B.E. , Halligan E.A. , Gardiner S.E. , Latch G.C.M.
Published: July 2020

To assist farmers and their advisers in becoming familiar with the many different varieties of Italian ryegrass currently available, this paper compares morphological, physiological and biochemical characteristics of Concord, Ceres Progrow, Lemtal (Belgium), Grasslands Tama, Grasslands Paroa, Grasslands Moata, Te Puna, Te Rahu, Bradley, Rakaia and also Grasslands Manawa, a hybrid cultivar which behaves as a persistent Italian ryegrass. In trials at Palmerston North in 1966/67, Moata stood out for its size in comparison to all other lines. Rakaia and Progrow from the South Island were short-lived and early heading, went directly to head after spring sowing and had large heads and many florets per spikelet, despite small size of leaves and plants. By contrast, Concord and Te Rahu from North Island dairy pastures were persistent, later heading and large in both vegetative and reproductive characteristics. All the varieties based on NZ material were quicker to germinate than any of the cultivars bred from overseas material, and, except Bradley, contained Acremonium endophyte. Keywords: Lolium multiflorum Lam., crown rust, germination, vernalisation, electrophoresis, seed protem banding, vegetative and reproductive characteristics, Acremonium endophyte.
COBALT DEFICIENCY IN THE KAIWERA DISTRICT, EASTERN SOUTHLAND
Authors: Sherrell C.G. , Mcintosh P.D. , Brunsden P.
Published: July 2020

SolIs and pastures were sampled at 96 sites in the Kaiwera district, an area having 12 soil types typical of eastern Southland and South Otago. Analyses indicated that ill-thrift in lambs could be due to low cobalt (Co) Intake. Upland (>300 m a.s.1.) topsoils had lower EDTA extractable Co than lowland topsoils and analysis of soil profile samples indicated that Co had been leached from upper horlzons of upland soils. Upland pastures contained much less Co than lowland pastures and Co concentration was much lower in February than in October. Sheep grazing on upland pasture had very low vitamin B 12 status from October to June and this coincided with low pasture Co concentration Sheep grazing on lowland pasture had adequate vitamin B l2, although pasture Co concentration fell to below 0.06 mg/kg for a short period in summer. We conclude that sheep grazed on upland pastures for long periods need supplementary Co or vitamin B 12 or need to be rotattonally grazed on lowland pasture to build up adequate reserves of vitamin 8, 2 Keywords: ill-thrift. sheep, vitamin B,2, pasture cobalt, seasonal variation
INTEGRATING DAIRYING WITH DAIRY BEEF AS A DIVERSIFICATION OPTION IN THE SOUTHERN SOUTH ISLAND
Authors: Crabbe C.L.
Published: July 2020

The integration of dairy beef with daitying in the southern South Island is a successful means of increasing stocking rates to maximise pasture utilisation when an increase in dairy cow numbers is not practical or economic. However the 1987-88 gross margins illustrate the vagaries of the beef market and the significant effect the schedule can have on the viability of integrating dairy beef even though there was considerable optimism at the start of the dairy season. In previous years the gross margin for bull beef, when the schedule has been about $2.OO/kg was closer to $lOOO/ha During the past season the nursecow option looks the most favourable in economic terms, allows for more management flexibility than bull beef and achieves the aim of maximising pasture utilisation. Keywords: dairy beef, dairying, bull beef
SYNTHESIS AND ELECTRICAL CONDUCTIVITY OF SOLID SOLUTIONS OF THE SYSTEM PbF2–NdF3–SnF2
Authors: Yuliia Pohorenko , Anatoliy Omel’chuk , Anton Nagornyi
Published: July 2020

In the system PbF2–NdF3–SnF2 are formed solid solutions of the heterovalent substitution Pb0,86-хNdхSn1,14F4+х (0 < x ≤ 0,17) with structure of β–PbSnF4. At x > 0,17 on the X-ray diffractograms, in addition to the basic structure, additional peaks are recorded to the reflexes of the individual NdF3. For single-phase solid solutions, the calculated parameters of the crystal lattice are satisfactorily described by the Vegard rule. The introduction of ions of Nd3+ into the initial structure leads to an increase in the parameter с of the elementary cell from 51.267 Å for x = 0,03 to 51.577 Å for x = 0.17. The replacement of a part of leads ions to neodymium ions an increase in electrical conductivity compared with Pb0.86Sn1.14F4. The slight replacement (3.0 mol. %) of Pb2+ ions by Nd3+ in the structure of Pb0.86Sn1.14F4 causes an increase in the electrical conductivity at T> 530 K (6.88·10-2 S/cm compared to 2.41·10-2 S/cm for the initial sample compound Pb0.86Sn1.14F4). In the region of lower temperatures, the electrical conductivity of the samples of this composition decreases, and below that temperature, on the contrary, slightly reduces the electrical conductivity, approaching the values characteristic of β-PbSnF4. The activation energy of the conductivity thus increases over the entire temperature range. A further increase in the concentration of Nd3+ ions in the synthesized samples causes an increase in their fluoride-ion conductivity throughout the temperature range. It should be noted that samples with a content of 10-15 mol% NdF3 at T>500 K have comparable conductivity values. At lower temperatures, the higher the conductivity, the higher the concentration of the substituent. The highest conductivity and the lowest activation energy have the sample Pb0.69Nd0.17Sn1.14F4.17 (σ373=3.68·10-2 S/сm, Ea=0,1 eV). The fluorine anions in synthesized phases are in three structurally-equivalent positions. The charge transfer is provided by the highly mobile interstitial fluorine anions, whose concentration increases with increasing temperature and concentration of NdF3. The transfer numbers for fluorine anions are not less than 0.99, practically independent of the concentration of neodymium trifluoride.
SYNTHESIS OF 4-HETARYL-2-(DICHLOROMETHYL)PYRAZOLO[1,5-a][1,3,5]-TRIAZINES
Authors: Velihina Yevgeniia , Kachaeva Maryna , Pil'o Stepan , Moskvina Viktoriia , Shablykina Olga , Brovarets Volodymyr
Published: July 2020

New pyrazolo[1,5-a][1,3,5]triazines with a heteroaromatic substituent in position 4 and dichloromethyl moiety in position 2 were obtained via a heterocyclization reaction of readily available reagents - N-(2,2-dichloro-1-cyanoethenyl)carboxamides and 3(5)-aminopyrazoles. The high efficiency of the proposed method for the synthesis of 2-(dichloromethyl)-pyrazolo[1,5-a][1,3,5]triazines with furan-2-yl, thien-2-yl, and pyridine-3-yl substituents was demonstrated.
Towards the Prediction of Rearrest during Out-of-Hospital Cardiac Arrest
Authors: Elola Andoni , Aramendi Elisabete , Rueda Enrique , Irusta Unai , Wang Henry , Idris Ahamed
Published: July 2020

A secondary arrest is frequent in patients that recover spontaneous circulation after an out-of-hospital cardiac arrest (OHCA). Rearrest events are associated to worse patient outcomes, but little is known on the heart dynamics that lead to rearrest. The prediction of rearrest could help improve OHCA patient outcomes. The aim of this study was to develop a machine learning model to predict rearrest. A random forest classifier based on 21 heart rate variability (HRV) and electrocardiogram (ECG) features was designed. An analysis interval of 2 min after recovery of spontaneous circulation was used to compute the features. The model was trained and tested using a repeated cross-validation procedure, on a cohort of 162 OHCA patients (55 with rearrest). The median (interquartile range) sensitivity (rearrest) and specificity (no-rearrest) of the model were 67.3% (9.1%) and 67.3% (10.3%), respectively, with median areas under the receiver operating characteristics and the precision–recall curves of 0.69 and 0.53, respectively. This is the first machine learning model to predict rearrest, and would provide clinically valuable information to the clinician in an automated way.
Cities4ZERO Approach to Foresight for Fostering Smart Energy Transition on Municipal Level
Authors: Tatar Merit , Kalvet Tarmo , Tiits Marek
Published: July 2020

Smart energy transition efforts at the municipal level are gaining importance and go far beyond implementing single projects. Decarbonising cities involves complex strategic planning and needs system level thinking and changes. This has been increasingly realised at the municipal level, but challenges remain regarding the tools, involvement of stakeholders and on the development of policies. The focus of the research is on the use of participatory foresight for fostering smart energy transition on a municipal level, the key benefits and success factors that participatory foresight brings, and the replicability of this approach. Within the novel Cities4ZERO framework, an overarching methodology for a smart urban decarbonisation transition, guiding cities through the process of developing the most appropriate strategies, plans, projects, as well as looking for the commitment of key local stakeholders for an effective transition–foresight framework, was developed and tested in five pilot cities. Foresight as applied within the Cities4ZERO framework creates a participatory process which brings stakeholders together to achieve unified scenarios, and a common vision for future urban decarbonisation strategies. The methodology is replicable and increases the quality of strategic energy planning by fostering long-term system thinking.
Physiological Importance of Pectin Modifying Genes During Rice Pollen Development
Authors: Kim Yu-Jin , Jeong Ho Young , Kang Seung-Yeon , Silva Jeniffer , Kim Eui-Jung , Park Soon Ki , Jung Ki-Hong , Lee Chanhui
Published: July 2020

Although cell wall dynamics, particularly modification of homogalacturonan (HGA, a major component of pectin) during pollen tube growth, have been extensively studied in dicot plants, little is known about how modification of the pollen tube cell wall regulates growth in monocot plants. In this study, we assessed the role of HGA modification during elongation of the rice pollen tube by adding a pectin methylesterase (PME) enzyme or a PME-inhibiting catechin extract (Polyphenon 60) to in vitro germination medium. Both treatments led to a severe decrease in the pollen germination rate and elongation. Furthermore, using monoclonal antibodies toward methyl-esterified and de-esterified HGA epitopes, it was found that exogenous treatment of PME and Polyphenon 60 resulted in the disruption of the distribution patterns of low- and high-methylesterified pectins upon pollen germination and during pollen tube elongation. Eleven PMEs and 13 PME inhibitors (PMEIs) were identified by publicly available transcriptome datasets and their specific expression was validated by qRT-PCR. Enzyme activity assays and subcellular localization using a heterologous expression system in tobacco leaves demonstrated that some of the pollen-specific PMEs and PMEIs possessed distinct enzymatic activities and targeted either the cell wall or other compartments. Taken together, our findings are the first line of evidence showing the essentiality of HGA methyl-esterification status during the germination and elongation of pollen tubes in rice, which is primarily governed by the fine-tuning of PME and PMEI activities.
WNT Signaling in Melanoma
Authors: Gajos-Michniewicz Anna , Czyz Malgorzata
Published: July 2020

WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer. WNT-signaling is classified into two categories: β-catenin-dependent signaling (canonical pathway) and β-catenin-independent signaling (non-canonical pathway), the latter can be further divided into WNT/planar cell polarity (PCP) and calcium pathways. WNT ligands are considered as unique directional growth factors that contribute to both cell proliferation and polarity. Origin of cancer can be diverse and therefore tissue-specific differences can be found in WNT-signaling between cancers, including specific mutations contributing to cancer development. This review focuses on the role of the WNT-signaling pathway in melanoma. The current view on the role of WNT-signaling in cancer immunity as well as a short summary of WNT pathway-related drugs under investigation are also provided.
Metabolomic Insight into Polycystic Ovary Syndrome—An Overview
Authors: Rajska Anna , Buszewska-Forajta Magdalena , Rachoń Dominik , Markuszewski Michał Jan
Published: July 2020

Searching for the mechanisms of the polycystic ovary syndrome (PCOS) pathophysiology has become a crucial aspect of research performed in the last decades. However, the pathogenesis of this complex and heterogeneous endocrinopathy remains unknown. Thus, there is a need to investigate the metabolic pathways, which could be involved in the pathophysiology of PCOS and to find the metabolic markers of this disorder. The application of metabolomics gives a promising insight into the research on PCOS. It is a valuable and rapidly expanding tool, enabling the discovery of novel metabolites, which may be the potential biomarkers of several metabolic and endocrine disorders. The utilization of this approach could also improve the process of diagnosis and therefore, make treatment more effective. This review article aims to summarize actual and meaningful metabolomic studies in PCOS and point to the potential biomarkers detected in serum, urine, and follicular fluid of the affected women.
Toxicity of TiO2 Nanoparticles: Validation of Alternative Models
Authors: Leroux Mélanie M. , Doumandji Zahra , Chézeau Laetitia , Gaté Laurent , Nahle Sara , Hocquel Romain , Zhernovkov Vadim , Migot Sylvie , Ghanbaja Jafar , Bonnet Céline , Schneider Raphaël , Rihn Bertrand H. , Ferrari Luc , Joubert Olivier
Published: July 2020

There are many studies concerning titanium dioxide (TiO2) nanoparticles (NP) toxicity. Nevertheless, there are few publications comparing in vitro and in vivo exposure, and even less comparing air–liquid interface exposure (ALI) with other in vitro and in vivo exposures. The identification and validation of common markers under different exposure conditions are relevant for the development of smart and quick nanotoxicity tests. In this work, cell viability was assessed in vitro by WST-1 and LDH assays after the exposure of NR8383 cells to TiO2 NP sample. To evaluate in vitro gene expression profile, NR8383 cells were exposed to TiO2 NP during 4 h at 3 cm2 of TiO2 NP/cm2 of cells or 19 μg/mL, in two settings—submerged cultures and ALI. For the in vivo study, Fischer 344 rats were exposed by inhalation to a nanostructured aerosol at a concentration of 10 mg/m3, 6 h/day, 5 days/week for 4 weeks. This was followed immediately by gene expression analysis. The results showed a low cytotoxic potential of TiO2 NP on NR8383 cells. Despite the absence of toxicity at the doses studied, the different exposures to TiO2 NP induce 18 common differentially expressed genes (DEG) which are involved in mitosis regulation, cell proliferation and apoptosis and inflammation transport of membrane proteins. Among these genes, we noticed the upregulation of Ccl4, Osm, Ccl7 and Bcl3 genes which could be suggested as early response biomarkers after exposure to TiO2 NP. On the other hand, the comparison of the three models helped us to validate the alternative ones, namely submerged and ALI approaches.
EIF4G1 and RAN as Possible Drivers for Malignant Pleural Mesothelioma
Authors: Dell’Anno Irene , Barbarino Marcella , Barone Elisa , Giordano Antonio , Luzzi Luca , Bottaro Maria , Migliore Loredana , Agostini Silvia , Melani Alessandra , Melaiu Ombretta , Catalano Calogerina , Cipollini Monica , Silvestri Roberto , Corrado Alda , Gemignani Federica , Landi Stefano
Published: July 2020

For malignant pleural mesothelioma (MPM) novel therapeutic strategies are urgently needed. In a previous study, we identified 51 putative cancer genes over-expressed in MPM tissues and cell lines. Here, we deepened the study on nine of them (ASS1, EIF4G1, GALNT7, GLUT1, IGF2BP3 (IMP3), ITGA4, RAN, SOD1, and THBS2) to ascertain whether they are truly mesothelial cancer driver genes (CDGs) or genes overexpressed in an adaptive response to the tumoral progression (“passenger genes”). Through a fast siRNA-based screening, we evaluated the consequences of gene depletion on migration, proliferation, colony formation capabilities, and caspase activities of four MPM (Mero-14, Mero-25, IST-Mes2, and NCI-H28) and one SV40-immortalized mesothelial cell line (MeT-5A) as a non-malignant model. The depletion of EIF4G1 and RAN significantly reduced cell proliferation and colony formation and increased caspase activity. In particular, the findings for RAN resemble those observed for other types of cancer. Thus, we evaluated the in vitro effects of importazole (IPZ), a small molecule inhibitor of the interaction between RAN and importin-β. We showed that IPZ could have effects similar to those observed following RAN gene silencing. We also found that primary cell lines from one out of three MPM patients were sensitive to IPZ. As EIF4G1 and RAN deserve further investigation with additional in vitro and in vivo studies, they emerged as promising CDGs, suggesting that their upregulation could play a role in mesothelial tumorigenesis and aggressiveness. Furthermore, present data propose the molecular pathways dependent on RAN as a putative pharmacological target for MPM patients in the view of a future personalized medicine.
Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders
Authors: Kim Taejoon , Song Bokyeong , Lee Im-Soon
Published: July 2020

Glial cells are key players in the proper formation and maintenance of the nervous system, thus contributing to neuronal health and disease in humans. However, little is known about the molecular pathways that govern glia–neuron communications in the diseased brain. Drosophila provides a useful in vivo model to explore the conserved molecular details of glial cell biology and their contributions to brain function and disease susceptibility. Herein, we review recent studies that explore glial functions in normal neuronal development, along with Drosophila models that seek to identify the pathological implications of glial defects in the context of various central nervous system disorders.
Anticancer Compounds Derived from Marine Diatoms
Authors: Hussein Hanaa Ali , Abdullah Mohd Azmuddin
Published: July 2020

Cancer is the main cause of death worldwide, so the discovery of new and effective therapeutic agents must be urgently addressed. Diatoms are rich in minerals and secondary metabolites such as saturated and unsaturated fatty acids, esters, acyl lipids, sterols, proteins, and flavonoids. These bioactive compounds have been reported as potent anti-cancer, anti-oxidant and anti-bacterial agents. Diatoms are unicellular photosynthetic organisms, which are important in the biogeochemical circulation of silica, nitrogen, and carbon, attributable to their short growth-cycle and high yield. The biosilica of diatoms is potentially effective as a carrier for targeted drug delivery in cancer therapy due to its high surface area, nano-porosity, bio-compatibility, and bio-degradability. In vivo studies have shown no significant symptoms of tissue damage in animal models, suggesting the suitability of a diatoms-based system as a safe nanocarrier in nano-medicine applications. This review presents an overview of diatoms’ microalgae possessing anti-cancer activities and the potential role of the diatoms and biosilica in the delivery of anticancer drugs. Diatoms-based antibodies and vitamin B12 as drug carriers are also elaborated.
Diabetes-Related Patient Outcomes through Comprehensive Medication Management Delivered by Clinical Pharmacists in a Rural Family Medicine Clinic
Authors: Prudencio Jarred , Kim Michelle
Published: July 2020

Two clinical pharmacy faculty members from a college of pharmacy provide comprehensive medication management in a rural family medicine clinic. The data was assessed for patients with diabetes managed by the pharmacists from 1 January 2017 through to 31 December 2019 to determine the service’s impact on patient outcomes. The primary outcome of this study is the change in the goal attainment rates of the three clinical goals of hemoglobin A1c, blood pressure, and appropriate statin therapy after pharmacist intervention. A total of 207 patients were included. At baseline, the patients had an average of 1.13 of the three goals met, improving to an average of 2.02 goals met after pharmacist intervention (p < 0.001). At baseline, 4.8% of the patients had met all three clinical goals, improving to 30.9% after pharmacist intervention (p < 0.001). There were significant improvements for the individual goal attainment rates of hemoglobin A1c (24.15% vs. 51.21%, p < 0.001), blood pressure (42.51% vs. 85.51%, p < 0.001), and appropriate statin therapy (45.89% vs. 65.70%, p < 0.001). This data adds to the evidence supporting the integration of clinical pharmacists into primary care clinics to improve patient outcomes related to diabetes.
Fast AHRS Filter for Accelerometer, Magnetometer, and Gyroscope Combination with Separated Sensor Corrections
Authors: Justa Josef , Šmídl Václav , Hamáček Aleš
Published: July 2020

A new predictor–corrector filter for attitude and heading reference systems (AHRS) using data from an orthogonal sensor combination of three accelerometers, three magnetometers and three gyroscopes is proposed. The filter uses the predictor—corrector structure, with prediction based on gyroscopes and independent correction steps for acceleration and magnetic field sensors. We propose two variants of the filter: (i) one using mathematical operations of special orthogonal group SO(3), that are accurate for nonlinear operations, for highest possible accuracy, and (ii) one using linearization of nonlinear operations for fast evaluation. Both approaches are quaternion-based filter realizations without redundant steps. The filters are compared to state of the art methods in this field on data recorded using low-cost microelectromechanical systems (MEMS) sensors with ground truth measured by the VICON optical system. Both filters achieved better accuracy than conventional methods at lower computational cost. The recorded data with ground truth reference and the source codes of both filters are publicly available.
A Fault Diagnosis Method of Rotating Machinery Based on One-Dimensional, Self-Normalizing Convolutional Neural Networks
Authors: Yang Jingli , Yin Shuangyan , Chang Yongqi , Gao Tianyu
Published: July 2020

Aiming at the fault diagnosis issue of rotating machinery, a novel method based on the deep learning theory is presented in this paper. By combining one-dimensional convolutional neural networks (1D-CNN) with self-normalizing neural networks (SNN), the proposed method can achieve high fault identification accuracy in a simple and compact architecture configuration. By taking advantage of the self-normalizing properties of the activation function SeLU, the stability and convergence of the fault diagnosis model are maintained. By introducing α -dropout mechanism twice to regularize the training process, the overfitting problem is resolved and the generalization capability of the model is further improved. The experimental results on the benchmark dataset show that the proposed method possesses high fault identification accuracy and excellent cross-load fault diagnosis capability.
Role of Intermediaries in Shaping Climate Finance in Developing Countries—Lessons from the Green Climate Fund
Authors: Chaudhury Abrar
Published: July 2020

Social scientists are increasingly interested in the processes that give shape to global policy solutions. I investigate the issues of intermediation and the role of intermediaries in climate finance. I use the case of the Green Climate Fund (GCF), a new consortium for dedicated funding set up under the United Nations Framework Convention on Climate Change (UNFCCC) to assist developing countries in responding to climate threats, to ask a fundamental question: What role do intermediaries (GCF-accredited and related entities) play in catalysing climate action through climate finance in these countries? This paper offers three propositions focused on the role of intermediaries in the GCF, and tests these using data from the GCF and the wider literature. The results show a growing dominance of international intermediaries in GCF project development and implementation, the low capacity of national intermediaries to conceive and scale projects, and the mismatch between planned and actual funding allocations. Collectively, these outcomes derail the GCF from its core objectives of promoting country ownership of projects, building capacity of local intermediaries, and equitable allocation of funding between mitigation and adaptation. I offer three learning models to help the GCF and intermediaries capitalise on the early lessons from GCF activities and to scale climate finance effectively in developing countries.
Stability of Non-Flexible vs. Flexible Inverted Bulk-Heterojunction Organic Solar Cells with ZnO as Electron Transport Layer Prepared by a Sol-Gel Spin Coating Method
Authors: Zamani-Meymian Mohammad-Reza , Sheikholeslami Saeb , Fallah Milad
Published: July 2020

In this research, inverted bulk heterojunction organic solar cells (BHJ OSC) with poly(3-hexylthiophene-2,5-diyl): (6,6)-phenyl C61 butyric acid methyl (P3HT:PCBM) as the active layer were fabricated by a sol-gel spin coating method using flexible PET and non-flexible glass as substrates. The power conversion efficiency (PCE) and the stability of the cells were investigated. According to the results, the non-flexible device showed higher short circuit current (Jsc) as well as open-circuit voltage (Voc) as compared to the flexible one so that 2.52% and 0.67% PCE for non-flexible and flexible cells were obtained, respectively. From the stability point of view, the non-flexible device maintained 51% of its initial efficiency after six weeks in a dark atmosphere, while it was about 19% for the flexible cell after four weeks. The most important reason for the higher PCE with the higher stability in the non-flexible cell can be attributed to its higher shunt resistance (Rsh) and better interlayer connections at the electron collector side.
LAW-REGULATING POTENTIAL OF THE RESOLUTION OF THE CONSTITUTIONAL COURT OF THE RUSSIAN FEDERATION NO. 44-П AS OF DECEMBER 6, 2018
Authors: Dzhamil’ Ella Z.
Published: July 2020

Every decision of the constitutional Court of the Russian Federation attracts the closest attention of the legal community, as it affects a wide range of public relations and the development of law in general. There is therefore no surprise about the interest in the Decision of the constitutional Court of the Russian Federation, on the 6th of December, 2018, No. 44-П adopted on business about check of constitutionality of the Law of the Republic of Ingushetia «On approval of the Agreement on the establishment of the border between the Republic of Ingushetia and the Chechen Republic» and the agreement on the establishment of the border between the Republic of Ingushetia and the Chechen Republic in connection with the request of the Head of Ingushetia, which marks another stage in the development of federalism in Russia. The conclusions formulated in this judgement clarify the competence of the Federation Council in terms of establishing the boundaries of constituent entities of the Russian Federation, which explains the issues related to the referendum and to identifi cation of the views
of the population of the respective municipalities when such a demarcation takes place, and defi nition of the limits of the discretionary powers of the constitutional (Charter) courts of constituent entities of the Russian Federation, in terms of blocking laws of the subjects. At the same time, many of the legal positions expressed by the Court appear to be at least controversial and need adequate refl ection.
STRESS MANAGEMENT IN PEDAGOGIC ACTIVITY: BASIC ORGANISATION DIRECTIONS
Authors: Zhukovskiy Vladimir P. , Skvortsova Larisa A. , Zhukovskaya Nina A.
Published: July 2020

The article examines issues related to the study of the problem fi eld of the stress phenomenon in pedagogic activity, consideration of the features of its manifestation in the pedagogic environment, the possibilities of organising stress management in the functional space of pedagogic work. Topicality of the research direction outlined in the article is determined by the high social signifi cance of pedagogic activity, which represents a special socio-professional space in which the whole spectrum of social relations, the variety of communicative contacts that are realised at different levels of the organisation of the educational process and with different categories of participants in educational relations are focused, hich objectively entails the emergence of situations that can destabilise a pedagogue’s personality, modify the procedural route of pedagogic activity and lead to the emergence and development of stress. A theoretical analysis of scientifi c research is conducted, devoted to the study of the conceptual space of the stress problem, its essential characteristics, manifestations in the pedagogic environment, factors determining the occurrence of stress among pedagogues, the content of stress management in the functional coordinates of pedagogic activity. Based on the study, a system of principles is defi ned that sets the guidelines for the substantive-procedural dynamics of stress management, which determines the priority personal and organisational vectors of the anti-stress management trajectory. The contents of the leading areas of stress management in pedagogic activity are disclosed, key organisational and pedagogic tools for their implementation in the pedagogic environment are identifi ed. According to the results of the study, it was found that the organisation of systematic work on stress management in pedagogic activities implemented in an educational organisation, the active integration of pedagogues as key subjects of pedagogic work
into its functional and process orbit, is an important factor in increasing the personal and professional success of a pedagogic worker, a necessary condition for the effectiveness of pedagogic activity and the development of the pedagogic environment.
THE DYNAMICS OF MOTIVATION FOR EDUCATIONAL ACTIVITIES OF BACHELOR STUDENTS IN THE DIRECTION OF «SOCIAL WORK»
Authors: Zarubina Yuliya N.
Published: July 2020

The article discusses the motivation of the educational activities of bachelor students in the direction of «Social Work». The factors and stages of the motivation process, the dynamic characteristics of the motivation system are revealed. The role of the motivational block in the structure of educational activities of students is revealed. A comparative analysis of the motivational profi le of students is carried out on the basis of studies of learning motivation conducted by the author in 2015 and 2019. Diagnostic tools have become the methodology «Studying the motivation of learning at a university» T.I. Il’ina and «Studying the motives of students’ teaching activities» by Artur Rean and Valeriy Yakunin. An additional research method was the analysis of essays in which students argue for the presence or absence of a desire to continue their education in a chosen direction and to continue to work in the social sphere. The results obtained made it possible to single out the most signifi cant learning motives and their dynamics among students of the Social Work direction. An analysis of the essay showed that in general, about 80% of students spoke more positively about the prospect of working in their acquired specialty. In conclusion, a conclusion is drawn about the growth of motivation indicators on the scale of «mastering a profession», maintaining the signifi cance of the «motives acquiring knowledge» and «obtaining a diploma», as well as the inclusion of the motive «receive intellectual satisfaction» as the priority motive instead of «gaining the approval of parents and others».
COGNITIVE CLOSURE CONCEPT: HISTORY AND RELEVANT NOTIONS
Authors: Yasin Miroslav I.
Published: July 2020

In this article a theoretical investigation of the concept of cognitive closure including the historical involvement of research on this issue and an analysis of the relevant notions is presented. The concept of cognitive closure is considered from a historical point of view – concepts and theories that logically lead to the issue of studying cognitive styles and cognitive closure in particular are given. Such notions as ambiguity intolerance, certainty orientation, desire for a simple cognitive structure, dogmatism, fundamentalism and rigidity of thought are presented to be closely related to the cognitive closure. The most extended and developed construct of cognitive closure is found in the Lay Epistemic Theory. The specifi city of the cognitive closure construct is that in the Lay Epistemic Theory, the emphasis was shifted from the tendency to get rid
of information as a psychological feature for an active dynamic (motivational) moment. Cognitive research is one of the promising areas of research in psychology, as it has great explanatory potential, which makes it possible to conduct applied research on various topics. Based on the qualitative and quantitative analysis of modern scientifi c periodicals, the most demanded lines of research are presented and it is concluded that the relevance of the topic is currently increasing.
SHOCK-BRIGADE OF SOVIET RUSSIA’S PEDAGOGIC INSTITUTES: PREREQUISITES FOR THE CREATION AND CONTENT OF UNPUBLISHED DECREES
Authors: Molokov Dmitry S.
Published: July 2020

The article reveals and analyses the content of unpublished decrees on the shock-brigade of higher educational institutes adopted in Soviet Russia at the late 1920s. Despite the fact that the documents were signed by the government of the country,
they have been practically not mentioned in the sourcebooks of legal acts, decrees of the Soviet government and historical and pedagogic literature. At the same time, they contributed to the transformation of the Russian system of pedagogic education,
defi ning a course for the centralisation of management and outlining the contours of the model of continuous professional training of pedagogues. Evaluation of the text of the resolutions, their correlation with socio-cultural and historical conditions allowed us to determine the prerequisites for the formation of a shock-brigade of higher pedagogic educational institutions. Based on the analysis of archival sources in the Upper Volga region, the article provides examples of implementing the decision on the shock-brigade of pedagogic institutes at the regional level. The research materials supplement scientifi c information about the features of the national educational policy in the fi eld of teacher training and can be used to supplement the sourcebooks of legal acts of the beginning of the Soviet period of Russian history, implement modern educational policy in the fi eld of pedagogic education, analyse the activities of supporting universities, supplement the educational literature and content of training courses on the history of pedagogy and education.