bluuebunny/crossref_metadata_2025 huggingface dataset:
Amyotrophic Lateral Sclerosis in Southwestern and Eastern Finland
Authors: Hanhisuanto Mirka , Solje Eino , Jokela Manu , Sipilä Jussi O.T.
Published: July 2023

Introduction: The incidence of amyotrophic lateral sclerosis (ALS) worldwide is approximately 1–2.6/1,000,000 and prevalence is 5–6/100,000. ALS has been suggested to be relatively common in Finland, but epidemiological information on the subject is scarce and outdated. Material and Methods: Patients with ALS diagnostic codes were identified from mandatory administrative registries in the provinces of Southwestern Finland (population circa 430,000) and North Karelia (population circa 170,000), together comprising 11.7% of the total population of Finland. The diagnoses were verified, and data were extracted by reviewing the patient records. Incidence period was 2010–2018, and the prevalence date was December 31, 2018. Age-standardization was performed using the European Standard Population 2013 (ESP2013). Results: Overall crude incidence of ALS was 4.2/100,000 person-years in Southwestern Finland (ESP2013: 4.0/100,000) and 5.6/100,000 person-years in North Karelia (ESP2013: 4.8/100,000), while crude prevalences were 11.9/100,000 (ESP2013: 10.5/100,000) and 10.9/100,000 (ESP2013: 9.3/100,000), respectively. Mean age at diagnosis was 65.5–71.6 years in women (higher in Southwestern Finland compared to North Karelia, p = 0.003) and 64.7–67.3 years in men (no difference between provinces, p = 0.39). The diagnosis had been made in 50% before the age of 70 years in Southwestern Finland and before the age of 65 years in 51% in North Karelia. Genetic testing had been conducted in 28% of all patients with the most common findings being SOD1 and C9orf72. After the diagnosis, mean survival was 2.0–2.7 and median survival 1.3–1.4 years. Onset phenotype (p < 0.001), age at diagnosis (p < 0.001), and genotype (p = 0.001) predicted survival. Riluzole had been used by 25% of patients and tracheostomy and invasive ventilation (TIV) had been performed in <1%. Conclusions: Both incidence and prevalence of ALS in Finland are among the highest in the world but with some notable differences between the eastern and southwestern parts of the country. Low median life expectancy may be related to the advanced age of patients and the high prevalence of C9orf72 repeat expansion in Finland as well infrequent use of TIV and riluzole.
Predictive Factors Associated with Long-Term Response to Combination Immunotherapy in Patients with Untreated Advanced Non-Small-Cell Lung Cancer: A Multicenter Retrospective Study
Authors: Sonehara Kei , Ozawa Ryota , Hama Mineyuki , Nozawa Shuhei , Agatsuma Toshihiko , Nishie Kenichi , Kato Akane , Matsuo Akemi , Araki Taisuke , Komatsu Masamichi , Tateishi Kazunari , Hanaoka Masayuki
Published: July 2023

Introduction: Combination immunotherapy is widely used in clinical practice as the first-line treatment for advanced non-small-cell lung cancer (NSCLC). However, predictive factors associated with long-term response to combination immunotherapy have not been well investigated. Herein, we compared the clinical findings, including systemic inflammatory nutritional biomarkers, between responders and nonresponders to combination immunotherapy. In addition, we investigated the predictive factors associated with long-term response to combination immunotherapy. Methods: This study included a total of 112 previously untreated advanced NSCLC patients who received combination immunotherapy at eight institutions in Nagano prefecture between December 2018 and April 2021. The responders were defined as those who achieved progression-free survival for 9 months or longer with combined immunotherapy. We evaluated predictive factors associated with long-term response, and the favorable prognostic predictors associated with overall survival (OS) using statistical analyses. Results: The responder and nonresponder groups included 54 and 58 patients, respectively. Compared with the nonresponder group, the responder group had significantly younger age (p = 0.046), higher prognostic nutritional index (44.8 vs. 40.7, p = 0.010), lower C-reactive protein/albumin ratio (CAR) (0.17 vs. 0.67, p = 0.001), and a higher rate of complete plus partial response (83.3% vs. 34.5%, p < 0.001). The area under the curve and optimal cut-off value for CAR were 0.691 and 0.215, respectively. The CAR and best objective response were identified as independent favorable prognostic predictors associated with OS in the multivariate analyses. Conclusion: The CAR and best objective response were suggested to be useful predictors of long-term response in NSCLC patients who received combination immunotherapy.
Intertwin Membrane Perforation and Umbilical Cord Entanglement after Laser Surgery for Twin-Twin Transfusion Syndrome: Prevalence, Risk Factors, and Outcome
Authors: Knijnenburg Patricia J.C. , Slaghekke Femke , Rahmattulla Chinar , Ge Yuchun , Scholl Irene M. , van Klink Jeanine M.M. , Haak Monique C. , Middeldorp Johanna M. , Sun Luming , Lopriore Enrico
Published: July 2023

Introduction: Perforation of the intertwin membrane can occur as a complication of fetoscopic laser surgery for twin-twin transfusion syndrome (TTTS). Data on the occurrence and the risk of subsequent cord entanglement are limited. The objective of this study was to assess the prevalence, risk factors and outcome of intertwin membrane perforation, and cord entanglement after laser surgery for TTTS. Methods: In this multicenter retrospective study, we included all TTTS pregnancies treated with laser surgery in two fetal therapy centers, Shanghai (China) and Leiden (the Netherlands) between 2002 and 2020. We evaluated the occurrence of intertwin membrane perforation and cord entanglement after laser, based on routine fortnightly ultrasound examination and investigated the risk factors and the association with adverse short- and long-term outcomes. Results: Perforation of the intertwin membrane occurred in 118 (16%) of the 761 TTTS pregnancies treated with laser surgery and was followed by cord entanglement in 21% (25/118). Perforation of the intertwin membrane was associated with higher laser power settings, 45.8 Watt versus 42.2 Watt (p = 0.029) and a second fetal surgery procedure 17% versus 6% (p < 0.001). The group with intertwin membrane perforation had a higher rate of caesarean section (77% vs. 31%, p < 0.001) and a lower gestational age at birth (30.7 vs. 33.3 weeks of gestation, p < 0.001) compared to the group with an intact intertwin membrane. Severe cerebral injury occurred more often in the group with intertwin membrane perforation, 9% (17/185) versus 5% (42/930), respectively (p = 0.019). Neurodevelopmental outcome at 2 years of age was similar between the groups with and without perforation of the intertwin membrane and between the subgroups with and without cord entanglement. Conclusion: Perforation of the intertwin membrane after laser occurred in 16% of TTTS cases treated with laser and led to cord entanglement in at least 1 in 5 cases. Intertwin membrane perforation was associated with a lower gestational age at birth and a higher rate of severe cerebral injury in surviving neonates.
Exploration of Multi-Gene DNA Barcode Markers to Reveal the Broad Genetic Diversity of Field Ticks (Acari: Ixodidae) in a Tropical Environment of Hainan Island, China
Authors: Lu Yajun , Zhao Yae , Hu Li , Zhang Wanyu , Xie Yunyun , Cheng Shi , Zheng Bin , Xia Qianfeng
Published: July 2023

Ticks are hematophagous arthropods and obligate ectoparasites of humans and other animals. This study focused on the molecular discrimination of ticks in the tropical environment of Hainan according to multi-gene DNA barcode markers with the expectation of accurately distinguishing species. A total of 420 ticks, including 49 adult ticks, 203 nymphal ticks, and 168 larval ticks, were collected in the field, and the 49 adult ticks were identified as Rhipicephalus turanicus, Dermacentor marginatus, and Haemaphysalis longicornis. The mitochondrial 16S rRNA, ribosomal 28S rRNA D2, and ribosomal internal transcribed spacer 2 (ITS2) regions were used as DNA barcode markers to discriminate species. According to basic local alignment search tool analysis against the GenBank database, 16S rRNA positively identified ticks in the Rhipicephalus, Dermacentor, and Haemaphysalis genera; the 28S rRNA D2 region identified ticks in the Rhipicephalus and Dermacentor genera; and ITS2 identified ticks as D. marginatus. Pairwise sequence comparisons based on these three regions were visualized with a Sequence Demarcation Tool matrix. Substitution saturation tests using data analysis and molecular biology and evolution revealed little substitution saturation (Iss < Iss.c, p < 0.05) in the 16S rRNA region for the Haemaphysalis genus; 28S rRNA D2 region for the Rhipicephalus, Dermacentor, and Haemaphysalis genera; and ITS2 region for the Rhipicephalus and Dermacentor genera. Distinctive sequences for which it is difficult to obtain good matches with the sequences available in GenBank exist in the ticks of Hainan. Future studies should obtain complementary sequences to refine and update the database for the molecular characterization of ticks.
2. Marie Jeanne Riccoboni
Authors: Isbell John Claiborne
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.

Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.

This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
5. Suzanne Necker
Authors: Isbell John Claiborne
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.

Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.

This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
11. Adélaïde Marie Émilie de Souza-Botelho
Authors: Isbell John Claiborne
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.

Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.

This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
Managing Physical and Market Constraints to Make Investment Decision: A Methodological Proposal Programmed in MATLAB
Authors: Pérez-Campdesuñer Reyner , Sánchez-Rodríguez Alexander , García-Vidal Gelmar , Martínez-Vivar Rodobaldo
Published: July 2023

The need to seek a balance between installed capacities and demand is an imperative for all companies. To respond to this demand, various proposals have been formulated, among which the Theory of Constraints stands out, although the application of these methodologies is always limited by financial availability. This research shows the results of the application of a methodological proposal applied in a pharmaceutical laboratory that allows managing the increase in physical or market constraints, as appropriate, also considering the incidence of capacities in supply chain management. To achieve the proposed objective, programming in MATLAB R2019a is used. The systematic application of the methodology allowed an optimal use of financial availability, an increase in the capacity utilization and an increase in the profits generated during the process.
Study on Chemical Constituents of the Enriched Extracts of Erigeron multiradiatus and Anti-thrombotic Effect on Zebrafish
Authors: Li Li , Jin Wenfang , Wang Yue , Yang Li , Zhang Zhi-Feng
Published: July 2023

Background

Erigeron multiradiatus (Lindl.) Benth. has been used for years to treat various diseases in Traditional Tibetan Medicine (TTM). Our previous studies have shown that E. multiradiatus extract has important pharmacological effects, such as anti-myocardial ischemia–reperfusion (I/R) injury, anti-inflammatory, and anti-diabetic effects. To date, there have been no reports on using this extract to treat thrombosis.

Objectives

The aim of this study was to enrich the active components of E. multiradiatus and to further investigate its anti-thrombotic activity.

Materials and Methods

We used D101 macroporous adsorption resin to enrich the main active substances of E. multiradiatus and performed quantitative determination using ultra-high-performance liquid chromatography with a photodiode array detector (UHPLC-PDA). Furthermore, we investigated the anti-thrombotic effects of E. multiradiatus using three models: an arachidonic acid-induced platelet aggregation thrombotic zebrafish model, a phenylhydrazine-induced red blood cell (RBC)-injuring thrombotic zebrafish model, and a ponatinib-induced vascular endothelial cell (VEC)-injuring thrombotic zebrafish model.

Results

The yield of active component enrichment of E. multiradiatus was 4.95% using the D101 resin. We accurately determined eight compounds in the extract. Our results showed that these extracts had significant anti-thrombotic effects in the three different zebrafish models.

Conclusion

The enriched extract of E. multiradiatus could be used as a natural anti-thrombotic agent. Our results will provide a reference for reasonable clinical applications of E. multiradiatus.
Exploring senior managers’ experiences preparedness to respond to COVID-19: a qualitative study in Iran
Authors: Najafi Hojatolah , Kavosi Zahra , Rakhshan Mahnaz , Karimi Jalal , Marzale Milad Ahmadi , Bijani Mostafa , Peyravi Mahmoudreza
Published: July 2023

Background

Epidemics caused by emerging respiratory viruses are challenging for the health system of most societies, and preparedness of the health system in responding to such epidemics is important. Therefore, the aim of this study was identifying different fields and key issues of the senior managers’ experiences preparedness to respond to the COVID-19 epidemic from the Iranian senior managers’ point of view.

Methods

This is a qualitative descriptive study. Eighteen in-depth and semi-structured individual interviews were conducted for data collection. For this purpose, 18 senior managers with work experience in managing the COVID-19 crisis were enrolled in the study using purposive sampling. The collected data were analyzed according to Graneheim and Lundman’s approach.

Results

Analysis of the data resulted in the emergence of five themes and twelve sub-themes. The main themes and sub-themes included: (1) capacity improvement consisting of performance improvement and logistic improvement; (2) resource and infrastructure management including supply and support of human resources, infrastructure improvement, and supply of equipment; (3) an increase in epidemiology capacity including epidemiology improvement and emerging disease surveillance; (4) application of the principles of disaster and emergency management including intra- and extra-organizational interaction management, disaster risk management, and data management; and (5) society resilience increase including improving adaptation skill and maintaining health and social participation.

Conclusion

The results of this study present the key issues for the management of future emergency situations. Health system managers and policymakers in Iran and other countries should be aware of these key issues and apply them in practice to prepare the health systems to respond to next outbreaks. Indeed, the study results can help policymakers and health system managers to plan to achieve acceptable preparedness for the management of such outbreaks.
Crystal structure of bis{[(cyclohexylimino)(phenylimino)-l5-(methyl)diethylazane-κ
2
N:N′]-(ethyl)-zinc(II)]}, C38H62N6Zn2
Authors: Han Hong-Fei , Li Hao-Yang , Wang Song , Wei Xue-Hong
Published: July 2023

C38H62N6Zn2, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 9.5907(4) Å, b = 10.6743(4) Å, c = 11.2593(4) Å, α = 

107.6980

(
10
)

∘

$107.6980{(10)}^{\circ }$

, β = 

113.5840

(
10
)

∘

$113.5840{(10)}^{\circ }$

, γ = 

97.2290

(
10
)

∘

$97.2290{(10)}^{\circ }$

, V = 965.12(6) Å3, Z = 1, R
gt(F) = 0.0232, wR
ref(F
2) = 0.0577, T = 200(2) K.
Co‐evolution within the plant holobiont drives host performance
Authors: Mesny Fantin , Hacquard Stéphane , Thomma Bart PHJ
Published: July 2023

Plants interact with a diversity of microorganisms that influence their growth and resilience, and they can therefore be considered as ecological entities, namely “plant holobionts,” rather than as singular organisms. In a plant holobiont, the assembly of above‐ and belowground microbiota is ruled by host, microbial, and environmental factors. Upon microorganism perception, plants activate immune signaling resulting in the secretion of factors that modulate microbiota composition. Additionally, metabolic interdependencies and antagonism between microbes are driving forces for community assemblies. We argue that complex plant–microbe and intermicrobial interactions have been selected for during evolution and may promote the survival and fitness of plants and their associated microorganisms as holobionts. As part of this process, plants evolved metabolite‐mediated strategies to selectively recruit beneficial microorganisms in their microbiota. Some of these microbiota members show host‐adaptation, from which mutualism may rapidly arise. In the holobiont, microbiota members also co‐evolved antagonistic activities that restrict proliferation of microbes with high pathogenic potential and can therefore prevent disease development. Co‐evolution within holobionts thus ultimately drives plant performance.
Optimization of Polynomial Functions on the NuSVR Algorithm Based on Machine Learning: Case Studies on Regression Datasets
Authors: Budi Setyo , Akrom Muhamad , Trisnapradika Gustina Alfa , Sutojo Totok , Prabowo Wahyu Aji Eko
Published: July 2023

Purpose: Experimental studies are usually costly, time-consuming, and resource-intensive when it comes to investigating prospective corrosion inhibitor compounds. Machine learning (ML) based on the quantitative structure-property relationship model (QSPR) has become a massive method for testing the effectiveness of chemical compounds as corrosion inhibitors. The main challenge in the ML method is to design a model that produces high prediction accuracy so that the properties of a material can be predicted accurately. In this study, we examine the performance of polynomial functions in the ML-based NuSVR algorithm in evaluating the regression dataset of corrosion inhibition efficiency of pyridine-quinoline compounds.Methods: Polynomial functions for NuSVR algorithm-based ML.Result: The outcomes demonstrate that the NuSVR model's prediction ability is greatly enhanced by the application of polynomial functions. Originality: The combination of polynomial functions and deep machine learning based NuSVR algorithms to increase the accuracy of predictive models.
Study on the Influence of Knowledge-driven Technology on predicting consumer Repurchase Behaviour
Authors: Chen Yajing , Leong Yee Choy , Yiing Lee Shin , Xiao Yunxia
Published: July 2023

Consumer purchase behaviour has become a potential research area in business analytics, as exploring micro-level details would increase the business's profitability. In this prospect, many MNCs and other enterprises harness contemporary computing technologies like Big Data Analytics, Deep Learning and Predictive Analytics to explore the latent knowledge in purchase patterns and customer behaviour. This work deploys a novel Multi-class Ada Boost (MAB) supported Convolutional Neural Network (CNN) to learn customer purchase behaviour by analysing the buying patterns and trends to predict the repurchases. The proposed model learns the trends sequentially as the CNN models are cascaded one after the other, thus preserving the contextual knowledge between the models. The proposed model is tested for its efficacy on Instacart Market Basket Analysis to predict whether the customer is repurchasing the same product. The performance of the proposed model is compared with another state of art Machine Learning algorithms like Logistic Regression (LR), Support Vector Machines (SVM), Random Forest (RF) and XGBoost in terms of prediction accuracy, precision and F1-score. In addition, synthetic noise is induced into the dataset at various levels to analyse the model's efficacy in handling noisy data. These results indicate that the model shows better results than its peers, thus making it more suitable to predict customer repurchase behaviour and pattern.
Влияние физической культуры на развитие важных качеств инженера
Authors: Зайцева Н.А. , Васенков Н.В.
Published: July 2023

В статье отражена важность сочетания физической активности и профессиональной деятельности для достижения успеха в карьере и личной жизни.
Nauka i religia
Authors: Dixon Thomas
Published: July 2023

Nauka i religia to przystępne wprowadzenie do zagadnienia. Kiedy zaczęły się kontrowersje między tymi dwoma obszarami? Jakich używa się argumentów filozoficznych w dyskusji o cudach? Co wspólnego z religią może mieć fizyka kwantowa, neurobiologia czy etyka ewolucyjna? Jaki jest kontekst społeczny, polityczny i etyczny relacji między nauką a religią? Jak relacja ta wygląda z perspektywy niechrześcijańskiej? Książka obowiązkowa dla każdego, kto ma - lub chce mieć - własne zdanie na temat natury i Boga.
Sztuczna inteligencja. Jej natura i przyszłość
Authors: Boden Margaret A.
Published: July 2023

Tomik w zwięzły i przystępny sposób prezentuje historię rozwoju sztucznej inteligencji, jej możliwości i ograniczenia. W jaki sposób działa? W jakich dziedzinach życia może być wykorzystana? Jakie zagrożenia stwarza? Jak zmienia nasze myślenie o człowieczeństwie?
Geopolityka
Authors: Dodds Klaus
Published: July 2023

Geopolityka pozwala zrozumieć sens aktualnych zdarzeń i zjawisk, w tym konfliktów, kryzysów, porozumień i projektów, zarówno w skali lokalnej, jak i międzynarodowej. W jaki sposób rozumienie geografii kształtuje politykę i ekonomię? Skąd bierze się populizm? Jak kino, Internet i media społecznościowe wpływają na mapy świata? Odpowiedzi na te pytania Czytelnik znajdzie w tej publikacji.
Relationship between atmospheric CH 4 and the calculated sea-to-air CH 4 flux
Authors: Zang Kunpeng , Wen Jun , Xu Xuemei , Pan Fengmei , Shen Xiaolong , Wei Kangxuan , Yi Lin , Yuanyuan Chen , Liu Shuo , Xu Honghui , Jiang Yujun , Fang Shuangxi
Published: July 2023

Background
Effect of atmospheric CH4 mole fraction on sea-to-air CH4 flux was important for assessment of carbon emissions, while it was paid little attention and lack of quantification.
Results
According to the method described by Wanninkhof (2014), the impacts of three different atmospheric CH4 data on the calculated sea-to-air CH4 flux were evaluated. Results showed that, compared to data observed at the Tae-ahn Peninsula station and the simulated MBL-CH4 references, in situ observed atmospheric CH4 mole fraction was 132 and 140 nmol/mol higher in July 2013, and 98 and 132 nmol/mol higher in February 2017 in the Bohai Sea, respectively. The different applied atmospheric CH4 mole fraction induced mean deviations of 1.5 µmol/m2/day in July 2013 and 1.0 µmol/m2/day in February 2017, respectively. In addition, effects of difference among three atmospheric CH4 mole fractions could result in greater deviations of calculated sea-to-air CH4 flux in summer in coastal shallow waters than that in winter in deep regions or open oceans.
Conclusions
From the perspective of narrowing the uncertainty of carbon emission, it was essential to calculate sea-to-air CH4 flux by using the field observed atmospheric CH4 mole fraction, especially in coastal shallow seas.
Synthesis,Characterization, Electronic structure, vibrational assignment, HOMO-LUMO, Mulliken Charge analysis , Docking and Antioxidant studies of (1-benzyl)-2-(2-arylaminothiazol-4-yl)benzimidazole
Authors: anashafer  , paul selvin pragalath
Published: July 2023

The compound of (1-benzyl)-2-(2-arylaminothiazol-4-yl)benzimidazole was characterized by IR spectra. The theoretical calculations of the mentioned compound have been carried out using the more popular density functional theory method, Beck’s-3-parameter-Lee Yang Parr (B3LYP) in 6-31G basic set. Optimized geometries of the molecule have been described and collate with the experimental values. The experimental atomic charges demonstrate adequate concurrence with the theoretical prediction from DFT. Theoretical spectral values have been interpreted and compared with FT-IR spectra. The IR spectra are obtained and assigned by vibrational analysis. The Mulliken population analysis on atomic charges has been computed using DFT calculation. A correlation between the theoretical and the experimental spectra has been achieved. The calculated HOMO and LUMO energy gaps also confirm that charge transfer occurs within the molecule. The compound C3 was highest activity against Hep-C cell line. Five membered heterocyclic moieties have been proved to posses strong biological activities. Hence a series of noval benzimidazolyl thiazoles were synthesized by multi-step reaction from 2- acetyl benzimidazole and hydroxylamine hydrochloride as starting materials and structure characterized by NMR and mass spectroscopy. The antioxidant activities of the derivatives were determined by DPPH scavenging assay.The synthesized compounds showed remarkable antioxidant activity
1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the
Treatment of Neurodegenerative Diseases
Authors: Chaudhary Jasmine , Jain Akash , Dhingra Ashwani , Chopra Bhawna , Sharma Vishal , Gupta Jatin , Kaushik Aditi
Published: July 2023

1,3-thiazoles, which contain nitrogen and a sulfur atom is an unsaturated five-membered
heterocyclic ring, have achieved a unique significant place in drug design and development because
of their versatile structure and a variety of pharmacological activities, viz. anticancer, antiviral,
antimicrobial, anticonvulsant, antioxidant, antidiabetic, etc. They have inspired researchers to
design novel thiazole with different biological activities. The presence of the thiazole moiety has resulted
in a large number of clinically useful drugs with a wide range of activities, such as Ritonavir
(antiviral), Sulfathiazole (antimicrobial antibiotic), Abafungin, Ravuconazole (antifungal), Meloxicam
(NSAID), etc., that further verify this statement. The prevalence of neurodegenerative diseases
like Alzheimer's, Parkinson's, and Huntington’s is increasing at a rapid pace but existing treatments
mainly provide symptomatic relief and are associated with undesired effects. Consequently, designing
novel compounds with more effectiveness and reduced toxicity are required. 1,3-thiazole derivatives
have emerged as excellent candidate in this regard and have an important role for the treatment
of neurodegenerative diseases. In the current review, we have gathered all the appropriate literature
which demonstrate the remarkable role of 1,3-thiazole and its derivatives in these diseases
that may help design new compounds with more desired characteristics. The literature was assessed
through worldwide scientific databases like GOOGLE, SCOPUS, and PUBMED using different
keywords, and only relevant information published in English was evaluated.
Przynależność do grupy rówieśniczej a zażywanie substancji psychoaktywnych w aspekcie profilaktycznej roli pielęgniarki
Authors: Krawczyk Marta
Published: July 2023

Wstęp. Poczucie własnej wartości u nastolatka jest zagadnieniem zasługującym na naszą uwagę. Dojrzewanie jest etapem pełnym zmian. Jest to czas ciągłego rozwoju, poszukiwania swojego miejsca w grupie rówieśniczej. Młodzież czuje ciągłą potrzebę eksperymentowania, dlatego jest narażona na uzależnienia od środków psychotropowych. Działania edukacyjne i profilaktyczne prowadzone przez opiekunów i pielęgniarki odgrywają znaczącą rolę w zapobieganiu powstawania uzależnień i stanów zagrożenia życia.

Cel. Celem pracy było zbadanie wpływu potrzeby przynależności do grupy rówieśniczej na rozpoczęcie zażywania dopalaczy i palenia marihuany.

Materiał i metody. Użytą metodą badawczą była metoda sondażu diagnostycznego, techniką badawczą było przeprowadzenie ankiety, a narzędziami badawczymi był Kwestionariusz KIDSCREEN, Test PUN, PUM oraz kwestionariusz ankiety własnego autorstwa.  Badanie przeprowadzono wśród 104 osób od 16 do 19 roku życia.

Wyniki. Według analizy wyników badań dopalacze stają się mniej popularne, a marihuana trafia do coraz liczniejszej grupy odbiorców na co wpływ ma potrzeba przynależności do grupy rówieśniczej. Aż 23% nastolatków uważa, że zapalenie marihuany poprawiło ich kontakt z koleżankami i kolegami, a większość z nich również pali.

Wnioski. Relacja z rówieśnikami wpływa na decyzję o zapaleniu marihuany, nie ma wpływu na osoby zażywające dopalacze. Na osoby decydujące się na inicjację narkotykową nie wpływa również pewność siebie, relacja z rówieśnikami oraz rodzicami.
Effective Prediction of Mortality by Heart Disease Among Women in Jordan Using the Chi-Squared Automatic Interaction Detection Model: Retrospective Validation Study
Authors: Bani Hani Salam , Ahmad Muayyad
Published: July 2023

Background

Many current studies have claimed that the actual risk of heart disease among women is equal to that in men. Using a large machine learning algorithm (MLA) data set to predict mortality in women, data mining techniques have been used to identify significant aspects of variables that help in identifying the primary causes of mortality within this target category of the population.

Objective

This study aims to predict mortality caused by heart disease among women, using an artificial intelligence technique–based MLA.

Methods

A retrospective design was used to retrieve big data from the electronic health records of 2028 women with heart disease. Data were collected for Jordanian women who were admitted to public health hospitals from 2015 to the end of 2021. We checked the extracted data for noise, consistency issues, and missing values. After categorizing, organizing, and cleaning the extracted data, the redundant data were eliminated.

Results

Out of 9 artificial intelligence models, the Chi-squared Automatic Interaction Detection model had the highest accuracy (93.25%) and area under the curve (0.825) among the build models. The participants were 62.6 (SD 15.4) years old on average. Angina pectoris was the most frequent diagnosis in the women's extracted files (n=1,264,000, 62.3%), followed by congestive heart failure (n=764,000, 37.7%). Age, systolic blood pressure readings with a cutoff value of >187 mm Hg, medical diagnosis (women diagnosed with congestive heart failure were at a higher risk of death [n=31, 16.58%]), pulse pressure with a cutoff value of 98 mm Hg, and oxygen saturation (measured using pulse oximetry) with a cutoff value of 93% were the main predictors for death among women.

Conclusions

To predict the outcomes in this study, we used big data that were extracted from the clinical variables from the electronic health records. The Chi-squared Automatic Interaction Detection model—an MLA—confirmed the precise identification of the key predictors of cardiovascular mortality among women and can be used as a practical tool for clinical prediction.
Adaptación al español de la escala Career Pathways Survey
Authors: Chuco Aguilar Victoria Judith
Published: July 2023

El fenómeno del Techo de Cristal, referido a las barreras invisibles que dificultan el acceso de las mujeres a puestos de alta jerarquía, plantea una serie de implicancias relacionadas a la discriminación de género, las cuales requieren ser analizadas en el ámbito académico. En ese sentido, en el presente artículo se adapta la Encuesta de Trayectoria Profesional al español para evaluar las dimensiones del Techo de Cristal en el ámbito organizacional. Asimismo, se analiza la brecha salarial, y los retos que plantea la existencia del fenómeno del Techo de Cristal. A través del presente estudio se pudo calcular la confiabilidad de la escala de 38 ítems tras adaptarla al español. Asimismo, los resultados del estudio permiten mejorar el nivel comprensión de los obstáculos a los que se enfrentan las mujeres en el lugar de trabajo y proporciona recomendaciones para futuras investigaciones y programas de intervención.
Quantifying diapir ascent velocities in power-law viscous rock under far-field stress: Integrating analytical estimates, 3D numerical calculations and geodynamic applications
Authors: Macherel Emilie , Podladchikov Yuri Yurivech , Räss Ludovic , Schmalholz Stefan Markus
Published: July 2023

Diapirism is crucial for heat and mass transfer in many geodynamic
processes. Understanding diapir ascent velocity is vital for assessing
its significance in various geodynamic settings. Although analytical
estimates exist for ascent velocities of diapirs in power-law viscous,
stress weakening fluids, they lack validation through 3D numerical
calculations. Here, we improve these estimates by incorporating combined
linear and power-law viscous flow and validate them using 3D numerical
calculations. We focus on a weak, buoyant sphere in a stress weakening
fluid subjected to far-field horizontal simple shear. The ascent
velocity depends on two stress ratios: (1) the ratio of buoyancy stress
to characteristic stress, controlling the transition from linear to
power-law viscous flow, and (2) the ratio of regional stress associated
with far-field shearing to characteristic stress. Comparing analytical
estimates with numerical calculations, we find analytical estimates are
accurate within a factor of two. However, discrepancies arise due to the
analytical assumption that deviatoric stresses around the diapir are
comparable to buoyancy stresses. Numerical results reveal significantly
smaller deviatoric stresses. As deviatoric stresses govern
stress-dependent, power-law, viscosity analytical estimates tend to
overestimate stress weakening. We introduce a shape factor to improve
accuracy. Additionally, we determine characteristic stresses for
representative mantle and lower crustal flow laws and discuss practical
implications in natural diapirism, such as sediment diapirs in
subduction zones, magmatic plutons or exhumation of ultra-high-pressure
rocks. Our study enhances understanding of diapir ascent velocities and
associated stress conditions, contributing to a thorough comprehension
of diapiric processes in geology.
Mastering all genres: Exploring Ninth Grade Students' Text Comprehension Skills Through Google Forms
Authors: Putra Hendra , Indra Indra , Ridha M , Hasan Reski
Published: July 2023

Understanding what one reads is a significant component of the reading journey. To effectively engage with different types of texts, students must possess strong reading comprehension skills. The goal of this study is to figure out how well kids can understand various forms of literature. Descriptive, recount, report, narrative, and procedural texts are examples of different types of texts. In this research, a quantitative method is utilized to perform data calculations. Reading assessments are incorporated as a tool in this process. The assessments consist of 25 questions and offer a selection of five text types: descriptive, recount, report, narrative, and procedure texts. The findings indicate that students have demonstrated a 50 percent proficiency in comprehending different text types, which suggests a relatively low level of overall comprehension. However, there is a positive trend observed in the children's understanding of descriptive language.
Transformasi Budaya Permainan Tradisional Ke Game Online Pada Remaja Di Desa Wonosari Kabupaten Jember
Authors: Wismawati Anik Fitri , Kamila Annisa Dini , Febrianti Putri Amalia , Riska Fitriyah
Published: July 2023

The rapid development of technology has contributed to influencing various aspects of life, one of which is culture in society. The game is one aspect of culture that has also experienced a change from the previous traditional game to an online game. Online games have become widely used since the pandemic hit in 2020. This has led to the change in social interaction that was formerly patembayan, to become individualism. This study aims to reveal the transition of game culture change in adolescents. This research was carried out using a qualitative approach and the research method used was ethnography in Wonosari Village, Jember Regency, East Java Province. Data collection was carried out through interviews and observations with adolescents in Wonosari Village using purposive sampling as the target of this study. The results of the study show that in the transition process starting from the invitation of friends and small habits it is what makes addiction and results in cultural change. Then this cultural change also produces a domino effect with changes in social interaction in adolescents.

ABSTRAK

Perkembangan teknologi yang semakin pesat turut andil dalam memengaruhi berbagai aspek dalam kehidupan, salah satunya kebudayaan pada masyarakat. Permainan merupakan salah satu aspek dalam kebudayaan juga turut mengalami perubahan dari sebelumnya permainan tradisional menjadi Game Online. Game Online menjadi marak digunakan sejak pandemic melanda pada 2020 silam. Hal ini, membuat ikut berubahnya interaksi sosial yang sebelumnya patembayan, menjadi individualism. Penelitian ini bertujuan untuk mengungkap transisi perubahan kebudayaan permainan pada remaja. Penelitian ini dilaksanakan dengan menggunakan pendekatan kualitatif dan metode riset yang digunakan ialah etnografi di Desa Wonosari, Kabupaten Jember, Provinsi Jawa Timur. Pengumpulan data dilakukan melalui wawancara dan observasi dengan remaja di Desa Wonosari secara purposive sampling sebagai sasaran penelitian ini. Hasil penelitian menunjukkan bahwa dalam proses transisinya dimulai dari ajakan teman dan kebiasaan kecil tersebutlah yang menjadikan kecanduan dan menghasilkan perubahan kebudayaan. Kemudian, perubahan kebudayaan ini juga turut menghasilkan efek domino dengan adanya perubahan interaksi sosial pada remaja
Hydroponic Planting Training to Maintain Food Security of the People of Bandar Setia Village, Percut Sei Tuan District, Deli Serdang Regency, North Sumatra
Authors: Budi Mulya Miswar , Nurtjahja Kiki , Putri Mimmy Sari Syah
Published: July 2023

The people of Bandar Setia Village experienced the impact of the implementation of PPKM due to regulations delimiting community activities. The limited agricultural land in the village also affects the fulfillment of food needs, especially vegetables. The purpose of this community service is to train the Forum Peduli Sesama Seniman Indonesia Cabang Tembung group representing the community of Bandar Setia in terms of hydroponic farming as an alternative to providing food stocks for the community in the village during the pandemic. The specific target of the training is the hydroponic model that can be made by the people of Bandar Setia village. The method used mixing counseling, training, hands-on practice, and work evaluation. Hydroponics manufacturing uses a mixing of NFT (nutrient film technique) and wick system methods. Vegetables harvested using hydroponics can be used for personal needs or sold according to the needs of the people of Bandar Setia village.
Fludarabine, cytarabine, and idarubicin with or without venetoclax in patients with relapsed/refractory acute myeloid leukemia
Authors: Shahswar Rabia , Beutel Gernot , Gabdoulline Razif , Schwarzer Adrian , Kloos Arnold , Koenecke Christian , Stadler Michael , Gohring Gudrun , Behrens Yvonne Lisa , Li Zhixiong , Dallmann Louisa-Kristin , Klement Piroska , Albert Catherin , Wichmann Martin , Alwie Yasmine , Benner Axel , Saadati Maral , Ganser Arnold , Thol Felicitas , Heuser Michael
Published: July 2023

Treatment options for relapsed and refractory acute myeloid leukemia patients (R/R AML) are limited. This retrospective cohort study compares safety and efficacy of fludarabine, cytarabine, and idarubicin (FLA-IDA) with or without venetoclax in patients with R/R AML. Thirty-seven and 81 patients received one course FLA-IDA with or without a 7-day course of venetoclax, respectively. The overall response rate (ORR) was significantly higher in FLAVIDA compared to FLA-IDA treated patients (78% vs. 47%; P=0.001), while MRD was negative at a similar proportion in responding patients (50% vs. 57%), respectively. Eightyone percent and 79% of patients proceeded to allogeneic hematopoietic cell transplantation (alloHCT) or donor lymphocyte infusion (DLI) after FLAVIDA and FLA-IDA, respectively. Event-free and overall survival were similar in FLAVIDA and FLA-IDA treated patients. Refractory patients could be salvaged more successfully after FLA-IDA compared to FLAVIDA pretreatment. Neutrophil and platelet recovery times were similar in the venetoclax and the control group. In conclusion, short-term venetoclax in combination with FLA-IDA represents an effective treatment regimen in R/R AML identifying chemosensitive patients rapidly and inducing MRD negative remission in a high proportion of R/R AML patients.
ASSOCIATION OF MAXILLARY IMPACTED CANINES WITH THIRD MOLAR AGENESIS AND OTHER DENTAL ANOMALIES
Authors: Bahadur Kosar , Nazir Ahmad  , Imran Tajik  , Sundus Faiz
Published: July 2023

Objectives: To fi nd out if there is an association of MICs (Maxillary impacted canines) with third molar agenesis and other dental anomalies.Materials and Methods: Data were collected using records of patients who visited the study setting during the study period. There were total 130 patients in the control group and 130 patients in the cases group. Pre-treatment records (OPG and CBCT) of all patients were used to assess impacted canines and missing third molars. Diff erence between the groups was assessed using chi-square test for categorical data.Results: The mean age was 20.2 ± 7.1 years for the control group and 20.2 ± 7.1 years for the cases group. In the control group, agenesis of third molar was found in 9.2% of the patients and in the impacted group the prevalence was found to be 42.3%. The results were statistically signifi cant. Other dental anomalies were also assessed, and the results showed that the MIC group had a higher prevalence of dental anomalies (36.2%) than the control group (5.4%).Conclusion: Maxillary impacted canine patients showed a higher prevalence of third molar agenesis and other dental anomalies. There was a signifi cant association between impacted canines and tooth agenesis other than third molars.
Metagenomics reveals the abundance and accumulation trend of antibiotic resistance gene profile under long-term no tillage in a rainfed agroecosystem
Authors: Wang Weiyan , Shen Pengfei , Lu Zhiqiang , Mo Fei , Liao Yuncheng , Wen Xiaoxia
Published: July 2023

Widespread soil resistance can seriously endanger sustainable food production and soil health. Conservation tillage is a promising practice for improving soil structure and health. However, the impact of long-term no-tillage on the presence of antibiotic resistance genes in agricultural soils remains unexplored. Based on the long-term (>11 yr) tillage experimental fields that include both conservation tillage practices [no tillage (ZT)] and conventional tillage practices [plough tillage (PT)], we investigated the accumulation trend of antibiotic resistance genes (ARGs) in farmland soils under long-term no-tillage conditions. We aimed to provide a scientific basis for formulating agricultural production strategies to promote ecological environment safety and human health. In comparison to PT, ZT led to a considerable reduction in the relative abundance of both antibiotic resistance genes and antibiotic target gene families in the soil. Furthermore, the abundance of all ARGs were considerably lower in the ZT soil. The classification of drug resistance showed that ZT substantially decreased the relative abundance of Ethambutol (59.97%), β-lactams (44.87%), Fosfomycin (35.82%), Sulfonamides (34.64%), Polymyxins (33.67%), MLSB (32.78%), Chloramphenicol (28.57%), Multi-drug resistance (26.22%), Efflux pump (23.46%), Aminoglycosides (16.79%), Trimethoprim (13.21%), Isoniazid (11.34%), Fluoroquinolone (6.21%) resistance genes, compared to PT soil. In addition, the abundance of the bacterial phyla Proteobacteria, Actinobacteria, Acidobacteria, and Gemmatimonadetes decreased considerably. The Mantel test indicated that long-term ZT practices substantially increased the abundance of beneficial microbial flora and inhibited the enrichment of ARGs in soil by improving soil microbial diversity, metabolic activity, increasing SOC, TN, and available Zn, and decreasing pH. Overall, long-term no-tillage practices inhibit the accumulation of antibiotic resistance genes in farmland soil, which is a promising agricultural management measure to reduce the accumulation risk of soil ARGs.