bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Cohesion and Conflict Dynamics on Social Media
Authors: Schirch Lisa
Published: November 2021

On May 20, 2021, the Canadian Association for Security and Intelligence Studies (CASIS) Vancouver hosted a digital roundtable where Dr. Lisa Schirch, Senior Research Fellow and Social Media, Technology and Peacebuilding Programme Director at the Toda Peace Institute, presented on Social Cohesion and Conflict Dynamics on Social Media. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives.
Does Canada have anything in the way of a strategic warning intelligence culture (and does it need one)?
Authors: Gilmour John
Published: November 2021

During the Cold War, Strategic Warning Intelligence (SWI) was a necessary and recognized function within the intelligence community given the threats posed by conventional Warsaw Pact forces in Western Europe and Soviet ballistic missiles. With the end of the Cold War, the focus of intelligence shifted to tactical or operational issues against known threats, and the SWI function and expertise atrophied as a result. With today’s expanding and more complex threat environment, this article examines whether SWI capacities should be reintroduced in order to apprise decision makers of trending threats to national security, albeit based on faint signals, so the necessary policy decisions can be made and prioritized to mitigate said threats in a timely manner.
Big Data Surveillance
Authors: Steeves Valerie
Published: November 2021

On October 21, 2021, Dr. Valerie Steeves presented Big Data Surveillance: Privacy and Trust Implications at the October 2021 CASIS Digital Roundtable event. This presentation was followed by a question and answer period, where CASIS Executives and attendees were given the opportunity to discuss the presentation with Dr. Steeves. The discussion topics included building an understanding of data surveillance for young people and safeguarding their privacy through building trusting relations.
THE RESULTS OF EXAMINATION OF MEDICAL CARE QUALITY FOR ASSOCIATED VERTEBRO-SPINAL-CORD INJURY
Authors: Shchedrenok V. V. , Yakovenko I. V. , Orlov S. V. , Simonova I. A. , Krasnoshlyk P. V. , Moguchaya O. V.
Published: November 2021

Medical care quality assessment for patients with vertebro-spinal-cord injury at different stages in St.-Petersburg during year was performed. The first aid in the most cases (74,8%) was rendered by emergency service. A vertebro-spinal-cord injuries were not diagnosed by a staff of line and special medical aid brigades in 31,6-51,9%. The causes of incorrect diagnostics at hospital stage: insufficient and delayed patient examination, underestimation of injury severity in consequence of delayed use of neuro-imaging methods. Surgical operations for vertebro-spinal-cord injuries were performed in 59 (8%) cases. 43 (73%) patients needed in vertebral fixation.
OSTEOSYNTHESIS OF THE SPINE AT PATHOLOGICAL FRACTURES AGAINST THE BACKGROUND OF EXTENSIVE METASTATIC SPREAD IN COMBINATION WITH RADIO- AND CHEMOTHERAPY
Authors: Tikhilov R. M. , Karagodin D. Ph. , Ptashnikov D. A. , Usikov D. V. , Magomedov Sh. Sh.
Published: November 2021

The results of the stabilizing spine osteosynthesis in 82 patients with extensive metastatic spread are presented. Patients have been distributed to 3 groups: in I group the extended osteosynthesis of a spine without application cement vertebroplasty was carried out, in II group the extended spine osteosynthesis was performed, but with performance vertebroplasty through cannulated screws, in III group the limited osteosynthesis with cement vertebroplasty through cannulas screws was applied. Results of treatment were estimated considering spine support ability, elimination of a painful syndrome (scale of pain McAfee, 1989) and neurologic dysfunctions (scale ASIA/IMSOP, 1992), improvement of quality of a life (scale SF-36). The received positive results of treatment allow to conclude that tactics of treatment has been chosen correctly.
THE PART OF PATHOMORPHOLOGIC STUDY IN SURGICAL TREATMENT PLANNING AT METASTATIC BONE TUMORS
Authors: Grigoryev P. V. , Zasulsky Ph. Yu. , Zaytseva M. Yu. , Usikov V. D. , Ptashnikov D. A.
Published: November 2021

The pathomorphologic study is the key examination in the therapy planning of patients with metastatic bone tumors. Since 1994 till 2009 424 patients with this pathology were treated in RRITO n.a. R. Vreden. The authors give clinical example showing the influence of pathomorphologic study results on the sequence of stages of complex treatment of patients with malignant tumors.
THE CORRECTION OF HALLUX VARUS DEFORMITY IN CONSEQUENCE OF SURGICAL TREATMENT FOR HALLUX VALGUS
Authors: Mashkov V. M. , Nesenyuk E. L. , Bezrodnaya N. V. , Shakhmatenko I. E.
Published: November 2021

The analysis of treatment of 21 patients (24 feet) with postoperative hallux varus deformity which have arisen after operations apropos hallux valgus is carried out. For correction of vicious position of the first finger we successfully carried out the Brandes procedure, sometimes in a combination to operations on sinews of muscles of the first finger - an adductor hallucis tendotomy and/or lengthening of the extensor hallucis longus tendon.
EXAMINATION RESULTS OF CHILDREN WITH CERVICAL SYNDROME
Authors: Bakhteeva N. H. , Ionova T. A. , Grigorjeva A. V.
Published: November 2021

By the example of examination of 80 children aged from 4 to 18 with cervical syndrome it is indicated, that the diagnosed abnormalities of hemodynamics in vertebrobasilar basin in patients of all age groups are connected both with bone and vascular pathology of the cervical part of the spine. The pathology has functional or congenital character. Early detection of discicirculatory vascular injuries in the cervical part of the spine in children with cervical syndrome will allow to define the therapeutic management of patients and to prolong juvenile osteochondrosis clinical behaviour.
FEATURES OF USING EXTERNAL AND SEQUENTIAL OSTEOSYNTHESIS IN CASUALITIES WITH GUNSHOT FRACTURES OF LONG BONES
Authors: Shapovalov V. M. , Khominets V. V.
Published: November 2021

In article the special features and the stage-treatment results of two groups of casualties with long bone gunshot fractures analysis have shown. In first group the casualties were treated by external ostheosynthesis (145 cases) and in second group the last ones were treated by the sequential two-step ostheosynthesis (29 cases) on medical evacuation stages. The two-step ostheosynthesis method supposed the external fixating device dismounting after the wound healing and further executing of subsequent internal ostheosynthesis by plates. The investigations have shown that proposed sequential ostheosynthesis technique allows to reliably reduce the average consolidation terms of wounded patients for about 19-26% accordingly to injured segment. The sequential ostheosynthesis technique indications were specified and its suitability was also proved for the second and third echelons of specialized orthopedic medical stages.
TREATMENT OF INTRA-ATICULAR FRACTURES OF THE PROXIMAL SEGMENT OF THE TIBIA
Authors: Klyuchevsky V. V. , Gerasimov M. P. , Dawi Saleh Haj Chikhmous , Mandzhlikyan A. N.
Published: November 2021

The experience of treatment of patients with intra-articular fractures of proximal segment of the tibia is presented. For improvement of diagnostics the body section radiography was used. Conservative methods were applied in 146 patients, surgical - in 202. The best results were achieved on application of dampening skeletal traction - 88,2%.
CORPOR- AND SPONDYLECTOMYIN SYSTEM OF SURGICAL TREATMENT OF VERTEBRAL TUMORS
Authors: Usikov V. D. , Ptashnikov D. A. , Magomedov Sh. Sh.
Published: November 2021

The authors have reported the 10-years experience of treatment of 571 patient with spinal tumors. Radical resection (en bloc) of tumors was done in 114 cases (65 - corpectomy, 55 - spondylectomy). The rate of tumors recurrence was - 9%, it depended from type of tumors and it's size.
TRANSORAL REMOVAL OF SKULL BASE AND C1-C2 VERTEBRAL BODY TUMOURS AND NONTUMOROUS PATHOLOGY IN THE CRANIOCERVICAL JUNCTION ACCOMPANIED BY CRANIOVERTEBRAL INSTABILITY
Authors: Shkarubo A. N. , Guscha A. O.
Published: November 2021

27 patients aged 2,5-61 years with skull base and C1-C2 vertebral body tumours and nontumorous pathology in the craniocervical junction underwent surgery. All patients revealed craniovertebral instability. To perform OSD we used autobone and metallic wire in 1 case, "Ventrofix" - 2; "CCD" - 9, "Vertex" - 15. In 26 cases OSD was followed by transoral tumor removal; in 1 - removal of the skull base chordoma spreading into C1-C2 segments was followed by OSD. In our practice we used original patent instruments, devices and surgical techniques. After the tumor has been removed, the skull defect hermetic closure and plasty were performed using the original patent technique for preventing postoperative CSF leakage as well as different glue compositions. This technique proved to shorten hospitalization period and reduce treatment costs as well as launch an early rehabilitation programme - on the 3d-4th day after operation. Use of new technologies in surgical treatment of skull base tumors invading upper cervical spinal segments accompanied by craniovertebral instability allowed to improve surgical outcome and start up early rehabilitation.
THE FEATURES OF TIBIOFIBULAR INJURY IN PATENTS WITH ANKLE FRACTURES
Authors: Fomin N. F. , Ovdenko A. G. , Nadjafov R. A. , Bogdanov A. N.
Published: November 2021

The role of interposition of soft tissues into tibiofibular syndesmosis is analyzed as a cause of unsatisfactory outcomes in the ankle joint pronation fracture treatment. The study is based on clinical (452 patients) and experimental material (36 experiments) including unfixed anatomic objects. The elevator for minimal invasive operative elimination of interposition of stumps of distal tibiofibular syndesmosis anterior and posterior ligaments is developed and tested.
TACTIC IN SURGICAL TREATMENT OF THORACIC IDIOPATHIC SCOLIOSIS IN CHILDREN
Authors: Vissarionov S. V. , Drozdetsky A. P.
Published: November 2021

The results of surgical treatment of 263 patients with thoracic scoliosis from 13 to 18 years old with deformity 50-152° (Cobb) are presented. It was used three tactical variants with dorsal instrumentation Cotrel-Dubousset (CDI). Operation correction in idiopathic thoracic scoliosis varies within in limits from 46,2 to 95%. Lost of correction in 10 years follow up period was 5,10-10,15%. Authors concluded that tactic of surgical treatment of idiopathic thoracic scoliosis should be individual and depends on patient's age, growth potential, and degree of deformation and mobility of the curve.
EXPERIMENTAL STUDY OF STABILITY AT CEMENT AND CEMENTLESS IMPLANTATION OF TRANSPEDICULAR SCREWS INTO VERTEBRAE WITH LOW MINERAL DENSITY OF BONE
Authors: Afaunov A. A. , Usikov V. D. , Ptashnikov D. A. , Takhmazyan K. K. , Dokish M. Yu.
Published: November 2021

The stability of cemented and noncemented transpedicular screw implantations in vertebra with low mineral bone density was studied in experiment. We analyzed the destabilization of screw under distraction load, attached along longitudal axis of the screw on universal servo-hydraulic test machine «Walter+bay ag» LFV-10-T50. The factors of bone-cement-metallic block rigidity of cemented screw was in 2,10-2,38 times more then in situation with traditional transpedicular screw.
ARTHROSCOPIC TREATMENT OF ELBOW CONTRACTURE IN SPORTSMAN
Authors: Kuznetsov L. A. , Rybin A. V. , Volokhovsky N. N. , Ryabinin M. V. , Yatsenyak N. T.
Published: November 2021

This is an example of treatment of a professional sportsman with osteochondritis dissecans and flexion-extension contracture of an elbow. As a result of treatment it was proven, that the arthroscopic method of treatment undoubtedly had an obvious positive effect compared to the traditional non-operative treatment. The course of treatment for such patients with similar pathologies should be an active one - the use of arthroscopy followed by a rehabilitation in order to achieve the best result possible.
MAGNETIC RESONANCE TOMOGRAPHY OF SPINE AFTER DISKECTOMY
Authors: Kholin A. V. , Sebelev K. I.
Published: November 2021

The author lists then possible immediate and remote complications after diskectomy and describes clinical presentations and methods of diagnostics at this pathology. Detailed MR-imaging of spine in 6 months after operation is presented.
THE ANTIMICROBIAL BIODEGRADABLE COMPOSITION BASED ON HIGH-MOLECULAR WEIGHT POLYVINYLPYRROLIDONE FOR THE PROPHYLAXIS OF EXPERIMENTAL OSTHEOMYELITIS
Authors: Afinogenov G. E. , Tikhilov R. M. , Afinogenova A. G. , Bogdanova T. Ya. , Krasnova M. V. , Kozlov I. V. , Darovskaya E. N. , Anisimova L. O. , Lebedeva I. K. , Petrova T. M.
Published: November 2021

The aim of study was to evaluate the efficacy of antimicrobial composition of amikacin with dioxydin and polyvinylpyrrolidone as a biodegradable prolonging agent for the post-surgery infections prophylaxis. The data obtained show the efficacy of the amikacin combination with dioxydin based on high-molecular weight polyvinylpyrrolidone and an opportunity to it's application for the post-surgery infections prophylaxis in traumatology, orthopedics and other surgery areas.
THE LATE RESULTS OF ARTHROSCOPIC SURGERIES WITH KNEE INJURIES IN CHILDREN
Authors: Bogatov V. D. , Bakhteeva N. Kh. , Mitrofanova V. A.
Published: November 2021

The purpose of the work is the follow-up of the late results of management of children and adolescents with knee injuries. Arthroscopy was performed to 68 patients. Resection and suturing of the torn meniscus and ACL reconstruction were performed. The results were followed up to eight years after operations. It was shown, that meniscal tears in children should be treated conservatively in most cases. The suturing of the torn menisci is preferable method. Indications for suturing are wider in children that in adults. ACL reconstruction in young patients is unpredictable in its results.
LONG-TERM RESULTS OF ENHANCED TAPERED STEM VerSys ET USE IN PRIMARY TOTAL HIP ARTHROPLASTY
Authors: Tikhilov R. M. , Shapovalov V. M. , Artyukh I. I. , Shubnyakov V. A.
Published: November 2021

The authors reported the outcome at a minimum of five years of 130 consecutive arthroplasties of VerSys ET (Zimmer) in 111 patients. The procedures were performed between 2001 and 2004. In 129 cases (99.2%) Trilogy cup (Zimmer) was used in one case - Muller's acetabular cage (Mathys). The mean age of patients was 49.5 (SD 11.5) (23 to 73), male 76 (58.5%), female - 54 (41.5%), overweight patients 109 (83.8%). Majority of patients had activity in Charnley class A. The most frequent was femur Dorr type A (27,0%) and Dorr type В (66,1%). The mean follow-up was 76 months (60 to 96). The outcomes assessed in 103 patients (120 hips) (92.3%). Outcomes of ten cases were not determined. The mean Harris Hip score improves from 35.1 (SD 8.3) preoperatively to 94.3 (SD 8.5) post-operatively. Kaplan-Meier analysis with revision of the stem as the end-point demonstrated 97,7% survival in term 60 to 96 months, for aseptic loosening - 99,2%. Subsidence of the implants in 61 (50.8%) patients was fixed at a mean follow-up 18.3 (SD3.7) months after surgery and did not progress further. After surgery stem position was neutral 91(75.8%) patients, varus - 14 (12.1%) and valgus - 14 (12.1%). Complications were observed in 8 (6.7%) cases: among them - periprosthetic fractures 6 (5.0%), stem aseptic loosening - 1 (0.8%), recurrent dislocation - 1 (0.8%). Four patients undergone revision surgery We consider the high efficiency of VerSys ET stem use for primary total hip arthroplasty.
THE RESULT OF INTRAMEDULLARY NAILING WITH BONE GRAFTING OF TIBIA'S PATHOLOGIC FRACTURE
Authors: Shapovalov V. M. , Khominets V. V. , Mikhajlov S. V. , Shakun D. A. , Turakulov F. I.
Published: November 2021

The authors give the clinical case of successful surgical treatment of patient with tibia's pathologic fracture by intramedullary nailing with bone grafting. The disadvantages of such patients' treatment by plaster immobilization and by some invasive methods like vascular autografting by Ilizarov's method and bone plating were also discussed. The obvious benefits of proposed surgical treatment technique of observed patient category are shown.
Factors Triggering Reinfection of the SARS-CoV-2 Virus in Post-Covid-19 Patients: Systematic Review (Preprint)
Authors: Fu'adah Syifail
Published: November 2021

BACKGROUND

Reinfection of the SARS-CoV-2 virus was a re-positive result detected using nasopharyngeal and oropharyngeal swab tests in all patients who had previously recovered.
Destination: This study aims to determine the factors that trigger reinfection of the SARS-CoV-2 virus in post-COVID-19 patients.

OBJECTIVE

This study aims to determine the factors that trigger reinfection of the SARS-CoV-2 virus in post-COVID-19 patients.

METHODS

The research method used is a meta-analysis of systematic reviews. Search for published articles through EBSCO Host, Wiley, PubMed, OVID, and Science Direct databases.

RESULTS

The triggering factors for reinfection of the SARS-CoV-2 virus are weak humoral immunity, the presence of SARS-CoV-2 exposure, the intermittent release of the SARS-CoV-2 virus in the body, mutations in the SARS-CoV-2 virus genome, and improper sampling or collection of samples.

CONCLUSIONS

The triggering factors for reinfection of the SARS-CoV-2 virus are weak humoral immunity, the presence of SARS-CoV-2 exposure, the intermittent release of the SARS-CoV-2 virus in the body, mutations in the SARS-CoV-2 virus genome, and improper sampling or collection of samples.
Clustering Analysis of the Care Problems of People with Dementia Based on the Minimum Spanning Tree Algorithm: A Cross-sectional Study (Preprint)
Authors: Leng Minmin , Sun Yue , Chang Hui , Wang Zhiwen
Published: November 2021

BACKGROUND

Recognizing the correlations between care problems of people with dementia could be beneficial, as it may help clinicians choose treatment methods because related symptom groups may respond to the same treatment intervention. However, generalizable data on the prevalence of care problems and potential clusters of care problems in people with dementia in China remain unavailable.

OBJECTIVE

This study aimed to (1) evaluate the prevalence of various care problems of people with dementia, and (2) explore the core care problems and the correlation between care problems of people with dementia.

METHODS

A cross-sectional study design was adopted to identify the care problems of people with dementia reported by family caregivers. The questionnaire consisted of two parts. The first part was mainly socio-demographic questions of people with dementia. The second part was the care problems evaluation sheet which involved three aspects: daily living care problems, behavioral and psychological symptoms, and safety risks. Care problems of people with dementia were measured with this care problems evaluation sheet. Clustering analysis of the care problems based on Kruskal's minimum spanning tree (MST) algorithm was performed in the Jupyter Notebook software to explore the core care problems and the correlation between care problems.

RESULTS

A total of 687 participants were included in the analysis. In general, the prevalence of having difficulty in language performance, agitated behavior, incidence of falls was relatively higher in people with dementia, which distressed their family caregivers. Through the clustering analysis based on the Kruskal's MST algorithm, the 63 care problems were clustered into 7 clusters. The 7 core care problems were “Don't know how to dress in order”, “Refusing to take a bath”, “Bedridden”, “Hitting, kicking, pushing, or biting others”, “Pacing and aimless wandering”, “Complaining”, and “Choking on food”.

CONCLUSIONS

The prevalence of various care problems was high. Through the clustering analysis, care problems were clustered into 7 clusters and 7 core care problems were identified. The identity of just a few core care problems instead of a large number of them might have relevant clinical implications, in the sense that it may lead to a greater ease in the identification of underlying etiologies and to more rational treatments in people with dementia.
Comparison of a Daily Smartphone App and Retrospective Questionnaire Measures of Adherence to Nicotine Replacement Therapy Among Pregnant Women: Observational Study (Preprint)
Authors: Emery Joanne , Huang Yue , Naughton Felix , Cooper Sue , McDaid Lisa , Dickinson Anne , Clark Miranda , Kinahan-Goodwin Darren , Thomson Ross , Phillips Lucy , Lewis Sarah , Coleman Tim
Published: November 2021

BACKGROUND

Few studies have investigated how to best measure adherence to smoking cessation medications, but continuous usage measures are recommended.

OBJECTIVE

In this first study of its kind, we compared methods for measuring adherence to nicotine replacement therapy (NRT) among pregnant women, investigating the completeness and validity of data collected from daily assessments using a smartphone app versus data collected from retrospective questionnaires.

METHODS

Women aged ≥16 years who were daily smokers and <25 weeks pregnant were offered smoking-cessation counseling and encouraged to use NRT. For 28 days after setting a quit date (QD), women were asked to report NRT use daily to a smartphone app and to questionnaires administered in person or remotely at 7 and 28 days. For both data collection methods, we provided up to £25 (~US $30) as compensation for the time taken providing research data. Data completeness and NRT use reported to the app and in questionnaires were compared. For each method, we also correlated mean daily nicotine doses reported within 7 days of the QD with Day 7 saliva cotinine concentrations.

RESULTS

Of the 438 women assessed for eligibility, 40 participated and 35 accepted NRT. More participants (31/35) submitted NRT usage data to the app by Day 28 (median 25, IQR 11 days) than completed the Day 28 questionnaire (24/35) or either of the two questionnaires (27/35). Data submitted to the app showed a lower reported duration of NRT use compared to that indicated in the questionnaire (median for app 24 days, IQR 10.25; median for questionnaire 28 days, IQR 4.75; P=.007), and there appeared to be specific cases of overreporting to the questionnaire. Mean daily nicotine doses between the QD and Day 7 were lower when calculated using app data (median for app 40 mg, IQR 52.1; median for questionnaire 40 mg, IQR 63.1; P=.001), and some large outliers were evident for the questionnaire. Mean daily nicotine doses, adjusted for cigarettes smoked, were not associated with cotinine concentrations for either method (app rs=0.184, P=.55; questionnaire rs=0.031, P=.92), but the small sample size meant that the analysis was likely underpowered.

CONCLUSIONS

Daily assessment of NRT use via a smartphone app facilitated more complete data (a higher response rate) than questionnaires, and reporting rates over 28 days were encouraging among pregnant women. App data had better face validity; retrospective questionnaires appeared to overestimate NRT use for some participants.
Methodological issues to analyse real-world longitudinal occupational health data (Preprint)
Authors: Colin Chevalier Rémi , Dutheil Frédéric , Dewavrin Samuel , Cornet Thomas , Baker Julien S , Pereira Bruno
Published: November 2021

UNSTRUCTURED

Ever greater technological advances and democratization of digital tools such as computers and smartphones offer researchers new possibilities to collect large amounts of health data in order to conduct clinical research. Such data, called real-world data (RWD), appears to be a perfect complement to traditional randomized clinical trials (RCTs) and has become more important in health decisions.
Due to its longitudinal nature, RWD is subject to well-known methodological issues that can occur when collecting this type of data. In this article, we present the three main methodological problems encountered by researchers, these include, the longitudinal data itself, missing data (not available - NA) and cluster-correlated data. These concepts have been widely discussed in the literature and many methods and solutions have been proposed to cope with these issues. As examples, mixed and trajectory models have been developed to explore longitudinal data sets, imputation methods can resolve NA issues, and multilevel models facilitate treating cluster-correlated data. This article reviews the various solutions proposed and attempts to analyze all three in detail.
Although solutions exist to meet these data collection challenges, solutions are not always correctly exploited, especially in cases where data collection issues overlap. In an attempt to solve this problem, we have conceived a process that considers all three issues simultaneously. This process can be divided into two parts: the first part of data management comprises of several phases such as definition of data structure, identification of suspect data and application of imputation methods. The second part of the analysis relates to the application of different models for repeated data using the modified data set. As a result, it should be possible to facilitate work with data sets and provide results with higher confidence levels. To support our proposal, we have used results from the “Wittyfit” database, which is an epidemiological database of occupational health data.
Machine learning to identify lung cancer with tuberculosis from isolated tuberculosis (Preprint)
Authors: Li Zhenhao
Published: November 2021

UNSTRUCTURED

Tuberculosis (TB) is a precipitating cause of lung cancer. Lung cancer patients coexisting with TB is difficult to differentiate from isolated TB patients. The aim of this study is to develop a prediction model in identifying those two diseases between the comorbidities and TB. In this work, based on the laboratory data from 389 patients, 81 features, including main laboratory examination of blood test, biochemical test, coagulation assay, tumor markers and baseline information, were initially used as integrated markers and then reduced to form a discrimination system consisting of 31 top-ranked indices. Patients diagnosed with TB PCR ＞1mtb/ml as negative samples, lung cancer patients with TB were confirmed by pathological examination and TB PCR ＞1mtb/ml as positive samples. We used Spatially Uniform ReliefF (SURF) algorithm to determine feature importance, and the predictive model was built using machine learning algorithm Random Forest. For cross-validation, the samples were randomly split into four training set and one test set. The selected features are composed of four tumor markers (Scc, Cyfra21-1, CEA, ProGRP and NSE), fifteen blood biochemical indices (GLU, IBIL, K, CL, Ur, NA, TBA, CHOL, SA, TG, A/G, AST, CA, CREA and CRP), six routine blood indices (EO#, EO%, MCV, RDW-S, LY# and MPV) and four coagulation indices (APTT ratio, APTT, PTA, TT ratio). This model presented a robust and stable classification performance, which can easily differentiate the comorbidity group from the isolated TB group with AUC, ACC, sensitivity and specificity of 0.8817, 0.8654, 0.8594 and 0.8656 for the training set, respectively. Overall, this work may provide a novel strategy for identifying the TB patients with lung cancer from routine admission lab examination with advantages of being timely and economical. It also indicated that our model with enough indices may further increase the effectiveness and efficiency of diagnosis.
Partisipasi Masyarakat Dalam Pengembangan Desa Wisata (Studi Kasus Desa Menang Kecamatan Pagu Kabupaten Kediri)
Authors: Salsabila Maya Sajidah , Fauzi Agus Machfud
Published: November 2021

The village won has tourism potential, namely Petilasan Sri Aji Jaya Baya and star fruit. The purpose of this study was to determine community participation in the development of a tourist village in Menang Village which eventually became one of the sources of economic improvement for the surrounding community. The method used in this research is qualitative because it can provide an overview of community participation in the development of a tourist village. The analysis uses Max Weber's theory of rationality. Max Weber's rationality theory can explain community participation in developing tourist villages. Collecting information by means of interviews, observation, and documentation. Based on the research results, there is community participation in the form of ideas, energy, and creativity. This is done by the community to work together to develop the star fruit tourism village in an effort to improve the community's economy.
CRISPR, ZFNS, and TALENS for Hemoglobinopathies an Analysis
Authors: Khare Venya
Published: November 2021

Abstract: Sickle Cell Disease is one of the most common genetic disorders in the United States and is incredibly prevalent throughout Africa and the Middle East. By 2050, the annual number of newborns with Sickle Cell Disease is projected to increase by 33%. A similar story can be told about Beta-Thalassemia: another hemoglobinopathy that has no standard treatment. The future of treating hemoglobinopathies looks bleak and more research must be done to prevent fatalities and the lifelong problems associated with it now. Sickle Cell Disease and Beta Thalassemia have one defining similarity: they are both monogenic disorders. This unique characteristic of having a single gene variation allows them to be the ideal candidate for one of the newest breakthroughs in biotechnology: target genome editing. As of now, there are three major competitors in the field, Zinc Finger Nuclease (ZFN), Transcription Activator-like Effector Nucleases (TALENs), and Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) target genome editing. Here I summarize the possibilities target genome editing provides in terms of research and a potential treatment for both Sickle Cell disease and Beta Thalassemia with a focus on comparing the three target genome editing technologies.
Comparison between Ideal and Practical Differentiators Using Operational Amplifier
Authors: Bhattacharjee Jhilik
Published: November 2021

Abstract: Operational Amplifier as differentiator plays an important role in electronics and electronic appliances. Inverting differentiator circuit is preferred compared to non-inverting differentiator circuit because of its high stability and better performance. In the present work, it is shown that preference should be given to the practical differentiator circuit using Operational Amplifier at frequency of 50 Hz with capacitance of 0.1 µF for getting improved result. This type of circuit can be used in different household and industrial as well as laboratory purposes. Keywords: Operational Amplifier, Differentiator circuit, Inverting and Non-Inverting circuits.
KÜLTÜREL MELEZLEŞMENİN SİNEMADAKİ GÖRÜNÜMÜ: LA GRAINE ET LE MULET ÖRNEĞİ
Authors: AŞKAN Hakan
Published: November 2021

Ulusal sınırları aşan insan hareketliliğinin yol açtığı kültürel karşılaşmalar ve bu karşılaşmaların sonuçları, küreselleşme çerçevesinde yürütülen tartışmaların da güncel konuları arasında yer almaktadır. Küreselleşmenin kapitalist ülkelerin lehine işlediğini öne süren yaklaşım, söz konusu tartışmayı kültürel hegemonya bağlamında ele almaktadır. Bu yaklaşım ”Birinci Dünya” kültürlerinin “Üçüncü Dünya” kültürlerine karşı daima baskın olduğunu iddia etmektedir. Buna karşın, bu karşılaşmaları yeni kültürel biçimlerin ortaya çıkmasına zemin hazırlayan bir takas süreci olarak ele alan bir yaklaşım da bulunmaktadır. Bu yaklaşım ise kültürel takas süreçlerinin melez biçimlerle sonuçlandığını iddia etmektedir. Sinemacıların kültürel kimlikleri, film üretim pratikleri ve filmlerinde ele aldıkları konular sinemanın bu tartışmaların görünürlük kazandığı önemli bir kültürel pratik alanı haline gelmesine yol açmaktadır. Dahası sinemanın kültürel kimlikleri temsil etme ve aktarma konusunda sahip olduğu yetkinlik sinemaya söz konusu tartışmaların irdelenebileceği zengin bir veri kaynağı olma özelliği de kazandırmaktadır.
Bu çalışmanın temel amacı, küreselleşmenin yarattığı kültürel melezleşmenin film üretim pratiğini ve anlatısını nasıl etkilediğini ortaya koymaktır. Çalışmada amaçlı örneklem yöntemine dayanılarak göçmen bir sinemacı olan Abdellatif Kechiche’in La Graine Et Le Mulet (The Secret of The Grain/Balıklı Bulgur) adlı filmi örneklem olarak belirlenmiştir. Söz konusu film, üretim pratiği ve anlatısı açısından iki farklı düzlemde durum çalışması (case study) yöntemiyle analiz edilmiştir. Çalışmadan elde edilen bulgular, söz konusu filmin üretim pratikleri ile anlatısındaki kültürel görünümlerin kayda değer düzeyde melez nitelikler barındırdığını ortaya çıkarmıştır. Ancak yine de özellikle anlatıdaki karakterlerin konuşma dili ve yine bu karakterlerin ev sahibi ülkenin mensupları tarafından algılanış biçimleri “kültürel hegemonya” olgusu çerçevesinde öne sürülen tezlerin de geçerli olabileceğini göstermiştir.
Estrategias de intervención en el campo literario-editorial: el caso de Nudista
Authors: Albrieu Nicolás
Published: November 2021

El presente artículo analiza algunas de las estrategias de intervención en el campo literario-editorial por parte de Nudista, pequeño sello editorial originario de la ciudad de Córdoba especializado en literatura. Entre las estrategias generales de posicionamiento de las pequeñas editoriales figuran su tendencia a construir espacios alternativos de comercialización y comunidades de lectura que agrupen a un núcleo fiel de colaboradores / lectores. Las estrategias que aquí analizamos (presentaciones, ciclos de lectura, producciones audiovisuales, performances varias) contribuyen en las dos dimensiones mencionadas, proporcionando espacios de socialización que funcionan, en primer lugar, como mercado privilegiado, garantizando un nivel mínimo de ventas, pero también, simultáneamente, como reserva de recursos humanos, proveyendo escritores, colaboradores y difusores de la producción de la editorial, y ofertando a los potenciales compradores / lectores algo más que un mero objeto de consumo.
Estadísticas de convivencia desde la aplicación del Código Nacional de Seguridad y Convivencia Ciudadana
Authors:   Policía Nacional de Colombia, Herrán Osorio Carlo Augusto , Jiménez Guerrero Hugo Armando ,   Policía Nacional de Colombia, Villota Benavides Leydi Viviana ,   Policía Nacional de Colombia, Dussán Quintana Julián Ricardo ,   Policía Nacional de Colombia
Published: November 2021

El presente artículo da a conocer los comportamientos contrarios a la convivencia registrados en Colombia a través de variables descriptivas que incluyen ciudades de ocurrencia, rangos de tiempo y grupos de edad registrados en el año 2020 durante la aplicación de la Ley 1801 de 2016 (Congreso de Colombia, 2016). La metodología empleada se fundamentó en un enfoque cuantitativo, un estudio de tipo descriptivo, un método basado en el análisis estadístico implicativo y un instrumento basado en el Registro Nacional de Medidas Correctivas - RNMC. Como principales resultados se registraron los siguientes: durante el año 2020 presentó un incremento de 1.020.959 comportamientos con respecto al año 2019, principalmente en el desacato de la función o la orden de policía. Las ciudades capitales con el 63,7% (1.434.796 registros) en ciudades como Bogotá, Medellín, Cali, Cartagena y Barranquilla. Se registran entre los días sábado y domingo representando el 34% y en referencia a las horas de ocurrencia estas corresponden a las 16:00 y 17:00 horas. En cuanto a la población infractora los jóvenes entre los 19 y 29 años son quienes registran el 55%. En el marco de la emergencia sanitaria generada por el COVID 19, el comportamiento más frecuente es el incumplimiento, desacato y obstaculización de órdenes de policía.
Epistemological issues of research of the subject and object of legal protection in genomic relations
Authors: Semyonovikh Anastasiya E.
Published: November 2021

The relevance of the research topic is justified by the rapid technological development of genetics and genomics and introduction of genetic technologies and inventions in scientific and medical practice, which is not provided with a proper systematized legal protection in national and international legislation. The legislators problems are caused by the uniqueness and complexity of the genomic legal relationship. The subjects of knowledge in the framework of post-non-classical scientific rationality need to focus on the epistemological philosophical foundations of the knowledge of genomic legal relations. The purpose of the study is to identify and reflect the features of knowledge of the legal protection of genomic legal relations. Research tasks suggest defining the concept and composition of genomic legal relations, identifying the object and subject of legal protection of genomic legal relations, distinguishing between the concepts of "legal safeguard" and "legal protection" of genomic legal relations. The methodology of scientific research includes the dialectical method, general scientific logical operations (deduction and induction, analysis and synthesis), and private scientific methods (formal legal and comparative legal methods). Within the framework of the methodology of post-non-classical scientific rationality, a systematic approach to the study of the object of knowledge is used - the study of the structure, functional and instrumental aspects of the protective genomic legal relationship.
Assessment of risk and safety of structures on slope areas according to geodetic monitoring data
Authors: Simonyan V.V. , Volkov V.I.
Published: November 2021

Nowadays, the definition of landslide risks is one of the most urgent tasks for many slope areas, since landslide processes directly affect the safety of buildings, structures and, accordingly, the population. As a rule, landslide risks are determined through the methods of engineering geology. Methods of mathematical modeling for assessing the risks of slope areas solve two main tasks
The Grassroots Innovation of Customary Forest Management: A Case Study of Kulawi-Marena Community in Sigi Regency, Central Sulawesi
Authors: Wibowo Ari , Palijama Martje Leninda , Kutanegara Pande Made , Cahyono Eko , Tillah Mardha
Published: November 2021

The Kulawi-Marena community is one of the communities with customary law units located in Sigi Regency, Central Sulawesi.They have inhabited the area around the forests of the Lore Lindu National Park (TNLL) long before Indonesia became a country. The Katuvua customary law system is a mechanism for effective natural resource management in preserving forests and ensuring social order, rather than the governance applied by national park managers. The writing of this article is based on research conducted by the author with the Indonesian Institute for Forest and Environment (RMI) with the support of FAO funds in 2018. Qualitative methods were used in the data collection process through Participatory Rural Appraisal (PRA), in-depth interviews, and Focus Group Discussions (FGD). This article describes the customary forest management practices by the Kulawi-Marena community based on the Katuvua customary law system. Furthermore, this article shows that this practice is a form of grassroots institutional innovation that reflects "sodality" according to the understanding that has been formulated by Prof. Tjondronegoro which in this case is for the context of people outside Java. This kind of grassroots innovation in forest management based on customary law can be used as a lesson for efforts to resolve agrarian conflicts around conservation areas.
Real-world Study of Antiresorptive-Related Osteonecrosis of Jaw Based on the US Food and Drug Administration Adverse Event Reporting System (FAERS) database
Authors: PENG JING , REN LEI , WU mingli , wang xia , wei Tian , li fang , Ban Bo
Published: November 2021

Objective To explore the risk signals of osteonecrosis of jaw induced by
antiresorptive drugs and provide references for the clinical safety
application. Method Based on the Food and Drug Administration Adverse
Event Reporting System (FAERS) from January 2004 to June 2021, We chosen
‘Osteonecrosis of jaw’ as Preferred Terms (PT) and antiresorptive drugs.
We used proportional reporting ratio (PRR), odds ratio (reporting odds
ratio, ROR), Bayesian confidence propagation neural network (BCPNN) and
multi-item Gamma-Poisson contraction (MGPS) algorithm to evaluate the
association between drugs and adverse events. Results 27,065 reports
related to osteonecrosis of the jaw in the FAERS dated from January 2004
to June 2021 . A total of 9 antiresorptive agents were included in the
analysis. Affected patients tended to be older than 65 years. Most cases
were reported from North America (39.82%) and Europe (36.15%) and were
submitted by health-care professionals (81.44%). Pamidronate and
clodronic acid showed a higher score than the other agents in every
method. Zoledronic acid and denosumab were reported more than other
agents.. Rate of hospitalization due to antiresorptive-related
osteonecrosis of the jaw was from 7.66% to 28.78%; rate of fatality
was from 0 to 12.78%. Conclusion All antiresorptive drugs may cause
ONJ, and ONJ can be effectively prevented. Practitioners should consider
the factors that may increase the likelihood of ONJ. The findings
support a continued surveillance and risk factor identification studies.
Staff Assignment Rotation and Project Sustainability in South Sudan
Authors: Kanneh Abraham Ansu , Awolusi Olawumi Dele
Published: November 2021

The primary objective of this study was to determine the existence of a causal relationship between Staff Assignment Rotation vis-à-vis Project Sustainability in South Sudan. The research followed the qualitative methodology predicated on the “philosophical dimensions” of constructivism and interpretivism. The participants for the research consisted of 50 individuals drawn from four population groups: Refugees as the primary beneficiaries, humanitarian workers and project staff. Qualitative data collection was chosen as the research methodology and in-depth interview and focus group discussion as the research techniques in the data collection. Narrative analysis was the method of data analysis. The study revealed that 81 percent of the respondents indicated security as the single most important factor that impacts project sustainability.  Staff assignment rotation followed with 16 percent. Data analysis was compartmentalized and looked at the profile of the respondents to see any noticeable variance from the functional perspective. Contextualizing the data helped to balance any perceived unbiased in the responses based on their functional affinity.  In addition to Security as the prominent factor that impacts project sustainability, staff rotation, government regulation, and funding could also impact significantly depending on the context. The study recommends a comprehensive review of the current mandatory policy to align the operation management cycle; encompassing the project initiation, planning, implementation, monitoring and closure to the standard assignment length of staff assigned to implement these projects.
Educational Props Development for Primary School and Early Childhood Education Teachers: Teachers Satisfaction Aspect
Authors: Mujtahid Iqbal Miftakhul , Berlian Mery , Vebrianto Rian , Thahir Musa
Published: November 2021

To maintain the continuity of science education through practicum/experimental activities, teachers have several problems in developing alternative simple science teaching aids which are easier and more affordable to provide and simple to use because they do not break easily. This study aims to analyze the level of satisfaction of the Community Service Program based on the problems faced by Elementary School and Early Childhood Education Teachers. This research is a cross-sectional study using a satisfaction survey of the assistance that has been carried out. The research subjects involved in this study were 30 participants who would be assessed in this study. The results showed that the Community Service Program succeeded in overcoming the problems faced by Elementary School and Early Childhood Education Teachers. This is evidenced by the high participation of teachers in participating in training and the success of teachers in developing educational teaching aids. This research has clear implications in developing innovative alternative media in the field of science.
Integration of Multiple Intelligences in Thematic Instructional Kit in Elementary School
Authors: Widiana I Komang , Sudarma I Komang , Dibia I Ketut
Published: November 2021

The learning carried out in schools has been dominated by the development of logic-mathematics intelligence. In fact, every student has various kinds of intelligence called multiple intelligences. This study aims to develop thematic instructional kit oriented to multiple intelligences. This research is a development research (R&D) which adapts the ADDIE model (Analyze, Design, Development, Implementation, and Evaluation). The instructional kit products developed in this study are in the form of a Lesson Plan (RPP) and Student Worksheets (LKPD). In this study, the product development validity test was only limited to the expert validation test stage. Data were collected using expert validation sheets. The results of research and development show that based on the results of the expert validity test that has been carried out, the average score of expert judgment is 4.88 for RPP products with very good categories, and 4.80 for LKPD products with very good categories. Based on these results, it can be concluded that the instructional kit products developed have good validity and quality to be applied in elementary schools.
Lectora Inspire Learning Media Based on Character Education in Civics
Authors: Audia Fyra Aldira , Zakiah Linda , Utami Nidya Chandra Muji
Published: November 2021

In the era of revolution 4.0, technology has an essential role in education, but teachers do not use technology in learning so that the impact on the learning process is less than optimal. This study aims to develop Lectora inspire learning media based on character education in Civics learning. This type of research is development research. The research method uses the research and development (R&D) development model of Hannafin and Peck. Three experts validate the media. The product trial subjects were 15 students. Data collection techniques by filling out a questionnaire. Quantitative data analysis techniques are based on the results of the calculation of answers on a Likert scale. The validation results from material experts obtained a score of 87.5%. The results of the validation of media experts obtained a score of 85%. The results of the validation of linguists obtained a score of 81%. The teacher obtained a score of 98%. The results of product trials to students obtained a score of 98%. It can be concluded that the learning media Lectora inspire based on character education in Civics learning is feasible to be used as a learning medium. This research implies that this media can be used to build students' character.