bluuebunny/crossref_metadata_2025 huggingface dataset:
Neutrophilic dermatosis of the face associated with aortitis syndrome and Hashimoto's thyroiditis.
Authors: Nakayama H , Shimao S , Hamamoto T , Munemura C , Nakai A
Published: July 2023

This is the first reported case of neutrophilic dermatosis of the face (Sweet's syndrome) associated with aortitis syndrome (Takayasu arteritis) and Hashimoto's thyroiditis. The patient was a 39/year/old Japanese female for whom corticosteroid therapy was effective.
UV/induced alterations in skin and lymphocytes during a one/week holiday in the Canary Islands in May.
Authors: Bech-Thomsen N , Munch-Petersen B , Lundgren K , Poulsen T , Wulf H C
Published: July 2023

The effect of solar exposure during a one/week sunbathing vacation in May at 29 degrees N latitude was investigated in 22 volunteers. The following end/points were measured before and after the holiday: skin reflectance at 507 nm, transmission of radiation from 289 nm to 448 nm through the epidermis, epidermal thickness, minimal erythema dose (MED), total white cell, neutrophil, lymphocyte, and lymphocyte subpopulation counts in blood, spontaneous DNA synthesis, DNA strand breaks and sister/chromatid exchange in lymphocytes, and the UVC tolerance of lymphocytes. There was a statistically significant decrease in skin reflectance (p < 0.001) and epidermal transmission (p < 0.01) after the holiday, reflecting increased pigmentation and epidermal thickening. There was a statistically significant increase in epidermal thickness (p < 0.001), MED (p < 0.05), spontaneous DNA synthesis (p < 0.01) and DNA strand breaks in lymphocytes (p < 0.02) after the holiday. The other end/points were not significantly changed. We report that changes in skin pigmentation and epidermal thickness occur after one week of UV exposure. It was also observed that a one/week UV exposure increased both spontaneous DNA repair and the amount of DNA strand breaks in the lymphocytes of the volunteers, while no changes in T/cell subsets were detected.
Severe infectious complications in a girl suffering from atopic dermatitis were found to be due to chronic granulomatous disease.
Authors: Jung K , Elsner J , Emmendörffer A , Bittrich A , Lohmann-Matthes M L , Roesler J
Published: July 2023

Recently, the diagnosis of a variant form of chronic granulomatous disease (CGD) could be established in an 11/year/old girl who had been treated for atopic dermatitis for many years. In addition to severe superinfections of lesions of the skin, the following symptoms were found currently or in her history: an episode of chronic diarrhoea (suspected as lactose intolerance), an endomyocarditis, a paranephritic abscess and recurrent lymph node abscesses. This case is demonstrated to underline the importance of extensive immunologic diagnostics in situations of recurrent severe infections of the skin, especially if other organs are involved. Diagnosis and type of CGD were strongly indicated by flow cytometrical measurement of H2O2 and cytochrome b558/expression by neutrophils and confirmed by a Western blot test. No immunoreactive p47phox could be found in the patient's cells. In this autosomal recessive variant of CGD some retained ability of phagocytes to produce reactive oxygen intermediates was present. Special management of patients with CGD is necessary to prevent serious infectious complications. Genetic counselling is another important consequence of the correct diagnosis.
Treatment of scleroderma with oral 1,25/dihydroxyvitamin D3: evaluation of skin involvement using non/invasive techniques. Results of an open prospective trial.
Authors: Humbert P , Dupond J L , Agache P , Laurent R , Rochefort A , Drobacheff C , De Wazieres B , Aubin F
Published: July 2023

1,25/dihydroxycholecalciferol (1,25 (OH)2 D3) causes dose/dependent inhibition of fibroblast growth and collagen synthesis and has numerous immunoregulatory activities. We assessed the effects of oral 1,25 (OH)2 D3 in the treatment of patients with systemic sclerosis (SS). Eleven patients with SS entered an open prospective study. Oral 1,25(OH)2 D3 was given at a mean dose of 1.75 micrograms/day. The effects of the treatment were evaluated using clinical examination and physical measurements. After the treatment period (6 months to 3 years), a significant improvement, as compared with baseline values, was observed. No serious side/effects were observed. These results suggest that high/dose 1,25 (OH)2 D3 may be a useful therapeutic agent for scleroderma.
Occupational acroosteolysis in a guitar player.
Authors: Baran R , Tosti A
Published: July 2023

A case of occupational acroosteolysis in a 24/year/old classical guitar player is reported. Nail tenderness was the only manifestation of initial acroosteolysis, which was due to mechanical stress on the fingers. Radiographs showed initial resorption of the 2nd, 3rd and 4th finger of the left hand. The authors review the clinical and radiological features of acroosteolysis. The pathogenesis of acroosteolysis is discussed as well as the different diseases that may cause destructive changes of the distal phalangeal bones.
Topical indomethacin aggravates the weal and flare response in chronic dermographic urticaria: evidence for a new class of histamine receptors.
Authors: Sharpe G R , Shuster S
Published: July 2023

The effect of topical indomethacin on the weal and flare response was measured in 9 patients with chronic dermographic urticaria. An augmentation of dermographic wealing by topical indomethacin was shown with lowering of the weal threshold from 22.3 +// 4.7 g/mm2 (mean +// SEM, n = 9) to 16.4 +// 3.8 (p < 0.005), but without a change in the shape of the force/response curve. Flare was increased by indomethacin particularly in patients with a greater lowering of the weal threshold. The augmentation of weal and flare by indomethacin in individual patients was not related to the degree of inhibition of UVB erythema in individual patients. These findings indicate that in chronic dermographic urticaria there is an abnormality involving eicosanoid production by a non/cyclo/oxygenase pathway. It is suggested that this acts by augmenting the effect of histamine on a new class of histamine receptor, the definition and antagonism of which should lead to better control of urticarial disease.
Immunomodulation of psoriasis with a topical cyclosporin A formulation.
Authors: Duncan J I , Wakeel R A , Winfield A J , Ormerod A D , Thomson A W
Published: July 2023

Topical cyclosporin A (CyA Sandimmun) in a formulation incorporating the penetration enhancers (PE) propylene glycol (18%) and azone (2%) was tested for efficacy in a double/blind, vehicle/controlled trial in 5 chronic plaque psoriatic patients. On each patient, two similar plaques were treated daily, under occlusion, for 4 weeks with either 8% (w/v) CyA, containing PE, or with vehicle comprising olive oil with PE. All sites improved significantly, but there was no significant difference between those receiving active and control preparations. Cryostat sections of biopsies performed after 4 weeks' treatment showed significant reductions in CyA compared with vehicle/treated sites in the number of cells, positive for CD3 and CD25 in the epidermis and CD25 and HLA/DR in the dermis. These results suggest that amounts of CyA adequate to affect the lymphocytic infiltrate penetrated the epidermis but that only partial suppression occurred in the dermis, as indicated by the reduction in lymphocyte activation status.
High frequency of thyroid dysfunction in patients with vitiligo.
Authors: Hegedüs L , Heidenheim M , Gervil M , Hjalgrim H , Høier-Madsen M
Published: July 2023

An association between vitiligo and autoimmune thyroid disease has previously been suspected. This study was undertaken to determine the frequency and type of thyroid disease in 35 consecutive patients admitted because of vitiligo compared with a matched control group. One or more signs of thyroid disease was demonstrated in 15 out of 35 patients (43%) with vitiligo, as compared to 7 out of 35 (20%) in the matched control group (p = 0.04). Thyroid dysfunction - 6 patients with hyperthyroidism and 2 with hypothyroidism - was found in 8 out of 35 patients, as compared to no patient in the control group (p = 0.003). Nine patients had thyroid autoantibodies, compared to 2 controls, and 6 had an enlarged thyroid gland, compared to 5 subjects in the control group. There appears to be an increased frequency of clinical as well as subclinical thyroid disease in patients with vitiligo. Our findings support the theory of vitiligo being an autoimmune disease and indicate a need for screening vitiligo patients for thyroid disease.
Leukocytoclastic vasculitis: another coumarin-induced hemorrhagic reaction.
Authors: Tamir A , Wolf R , Brenner S
Published: July 2023

A 67-year-old male developed a hemorrhagic eruption 4 weeks after initiation of coumarin therapy. Examination revealed a well-demarcated, purple patch with a central hemorrhagic bulla on the anterior aspect of the leg, surrounded by small petechiae. Histological examination of the purple plaque revealed leukocytoclastic vasculitis. It is suggested that leukocytoclastic vasculitis be considered in the differential diagnosis of coumarin-induced hemorrhagic reactions.
Abnormalities of plasma lipoprotein composition and fluidity in psoriasis.
Authors: Ferretti G , Alleva R , Taus M , Simonetti O , Cinti B , Offidani A M , Bossi G , Curatola G
Published: July 2023

We have studied the lipoprotein chemical composition and fluidity, using the fluorescence polarization of the probe 1,6-diphenyl-1,3,5-hexatriene (DPH) in two age- and sex-matched groups of subjects (14 healthy normolipidemic children and 15 psoriatic children). The compositional study has shown a significant increase of the percentage content in triacylglycerol and a significant decrease of the apo-protein content in all lipoprotein fractions of psoriatic children compared to the controls. A significant increase of the percentage content in total cholesterol and of the cholesterol/protein ratio has also been observed in low-density lipoproteins (LDL) and in high-density lipoproteins (HDL) of psoriatic children. The compositional changes were associated with alterations of fluidity in LDL and HDL of psoriatic patients. The modifications of lipoprotein composition and fluidity observed in psoriatic patients could be of physiopathological and clinical relevance in relation to the pathogenesis of the disease.
Immunoelectron microscopy of skin basement membrane zone antigens: a pre-embedding method using 1-nm immunogold with silver enhancement.
Authors: McGrath J A , Ishida-Yamamoto A , Shimizu H , Fine J D , Eady R A
Published: July 2023

There is no single immunoelectron microscopical method for invariably effective localization of both intracellular and extracellular antigens. We describe a simple and practicable immunogold technique that can be used to localize various skin basement membrane zone antigens at the ultrastructural level. Small pieces of skin were incubated with primary antibodies recognizing epitopes on a range of basement membrane zone-related antigens (two different lamina lucida-associated antigens, laminin, type VII collagen, fibrillin and keratin 14). This was followed by incubation with 1-nm colloidal gold-conjugated secondary antibody and subsequent silver intensification. The specimens were then processed for transmission electron microscopy. Precise immunolocalization with good ultrastructural preservation was achieved for all basement membrane zone antibodies tested. The results of basal cell keratin immunostaining showed that this microscopic approach could also be applied to some extent in the characterization of intracellular antigens. This immunoelectron microscopy technique provides a useful approach to the study of macromolecules at the basement membrane zone.
In vitro and in vivo effects of photodynamic therapy in cutaneous T cell lymphoma.
Authors: Boehncke W H , König K , Rück A , Kaufmann R , Sterry W
Published: July 2023

Photodynamic therapy consists of the combination of photosensitizers absorbing light in the visible spectral region and irradiation with light of corresponding wavelengths. We analysed its effects in comparison to PUVA treatment on cell lines MyLA and HuT78, established from patients with cutaneous T cell lymphomas. Proliferation was reduced to 50% by exposure to 7.5 J/cm2 UV-A (= ED50). This effect was increased more than 10-fold in the presence of 10 micrograms/ml 8-methoxypsoralen. The ED50 for photodynamic therapy using 630 nm light emitted by a dye laser and 10 micrograms/ml Photosan-3 was found to be about 1 J/cm2. In vivo fluorescence recordings during topical photodynamic therapy of mycosis fungoides lesions showed photo-bleaching and thus documented the triggering of photochemical reactions. Our observations document the capability of photodynamic therapy to inhibit proliferation of transformed T cells similar to PUVA, pointing out its potential in the treatment of cutaneous T cell lymphomas.
Inflammatory linear verrucous epidermal naevus with auto-immune thyroiditis: coexistence of two auto-immune epithelial inflammations?
Authors: Dereure O , Paillet C , Bonnel F , Guilhou J J
Published: July 2023

We report a patient with an inflammatory linear verrucous epidermal naevus (ILVEN) coexisting with an auto-immune lymphocytic thyroiditis. The occurrence of two epithelial inflammatory processes could be linked and raises the question of auto-immune involvement in the inflammatory part of ILVEN. Moreover, expression of a membrane antigen, OKM5, usually assigned to antigen-presenting cells, especially macrophages, has been demonstrated on keratinocytes in some dermatological diseases including ILVEN. These data suggest that keratinocytes in ILVEN could present some antigens and perhaps auto-antigens modified by the hamartomatous process, leading to an (auto-immune?) inflammatory reaction.
Amyloid in basal cell carcinoma and seborrheic keratosis.
Authors: Olsen K E , Westermark P
Published: July 2023

The frequency of amyloid substance was studied in two different types of skin tumours: basal cell carcinoma and seborrheic keratosis. In 9 out of 49 cases of seborrheic keratosis amyloid substance was found. In the basal cell carcinomas, 194 out of 260 cases showed amyloid deposits, a rate that is higher than that previously reported. The basal cell carcinoma material was further studied regarding the amount of amyloid, mitotic rate, degree of apoptosis and the age of the patients. There was no correlation between the amount of amyloid and the mitotic rate, or the degree of apoptosis. There was a slightly higher incidence of amyloid-positive cases among elderly patients.
Cytokeratin expression in alopecia areata hair follicles.
Authors: Van Baar H M , Van Vlijmen I M , Ramaekers F C , Van Muijen G N , Troyanovsky S M , Perret C M , Van de Kerkhof P C , Schalkwijk J
Published: July 2023

Alopecia areata is a human hair disease of unknown etiology. Immunological mechanisms, alterations in the extracellular matrix and follicular growth abnormalities have been suggested as a possible cause. Here we compare the expression of cytokeratins in normal hair follicles to that of alopecia areata using immunohistology with monoclonal antibodies. A number of cytokeratins were specifically expressed in defined anatomical parts of the follicle however, no gross qualitative or quantitative differences were found between normal and diseased scalp. Interestingly, the expression of cytokeratin 16, which is modulated by conditions that affect the rate of keratinocyte proliferation, was found to be unchanged in the outer root sheet of alopecia areata follicles. This is in contrast with earlier observations of a decrease in the expression of the proliferation-associated, Ki-67 nuclear antigen.
An immunohistochemical study of lysozyme in the skin of psoriatic patients.
Authors: Gasior-Chrzan B , Bostad L , Falk E S
Published: July 2023

The distribution of lysozyme was investigated in psoriatic skin lesions, perilesional skin and in skin from healthy controls, using the immunoperoxidase techniques avidin-biotin complex and alkaline phosphatase-anti alkaline phosphatase. Lysozyme was identified in polymorphonuclear leukocytes present in the Munro microabscesses and also occasionally in other parts of the skin, as shown by very strong cytoplasmic staining. Stratum corneum, stratum granulosum and stratum spinosum were weakly stained. In some cases positive staining along the dermal collagen bundles was demonstrated and is most likely to be related to the number of inflammatory cells in the papillary dermis. Psoriatic skin lesions stained significantly stronger for lysozyme than did perilesional skin (p < 0.0001), whereas skin from healthy controls stained weakly positive or was lysozyme negative. Lysozyme may be of some importance in the psoriatic disease process. By comparison the alkaline phosphatase-anti-alkaline phosphatase was found to be the most specific of the two techniques.
Interleukin 1 alpha (IL-1 alpha) in human skin in vivo: lack of correlation to markers of collagen metabolism.
Authors: Kylmäniemi M , Autio P , Oikarinen A
Published: July 2023

Levels of interleukin 1 alpha (IL-1 alpha) were studied from blister fluids collected from 14 patients with various types of blistering diseases. In all the fluids, IL-1 alpha could be detected, the concentrations varying from 5 to 1730 pg/ml. For comparison IL-1 alpha was also assayed from suction blisters of 13 subjects 8 atopic patients and 5 healthy controls. IL-1 alpha was also present in suction blisters in measurable quantities, suggesting that during suction IL-1 alpha is released into the blister cavity. Since IL-1 alpha has been shown to have marked effects on collagen metabolism, the marker of collagen synthesis (carboxyterminal propeptide of type I procollagen (PICP)) and gelatinase were assayed from the same samples. There was no apparent correlation between the levels of IL-1 alpha, PICP or gelatinase in blister fluids. The possible association of IL-1 alpha and collagen metabolism was further studied in experimental conditions. Topical glucocorticoid markedly decreased the level of PICP in suction blisters but did not have any significant effect on IL-1 alpha. UVB-radiation, on the other hand, caused increase in IL-1 alpha but did not have any profound effect on collagen metabolism. During the re-epithelialization of the blister floor the level of IL-1 alpha decreased markedly, and at the same time the expression of gelatinase was increased. The results indicate that IL-1 alpha is released in large quantities into blister fluid when using the suction blister model. However, no apparent correlation could be observed in healthy or diseased skin between the levels of IL-1 alpha, collagen synthesis marker or gelatinase.
E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis.
Authors: Rilo H L , Carroll P B , Subbotin V , Johnson N , Van Thiel D H , Thomson A W
Published: July 2023

A study of the histopathological abnormalities in a case of alopecia universalis was accompanied by immunohistochemical analysis of the expression of intercellular adhesion molecule-1 (ICAM-1) and E-selectin (formerly known as endothelial leukocyte adhesion molecule-1) within the skin. ICAM-1 expression on follicular epithelium co-localized with intraepithelial mononuclear cells (MNC) positive for the interleukin-2 receptor alpha-chain (IL-2R) or HLA-DR. Aberrant expression of E-selectin was observed on dermal endothelium. Although restricted to one case, these new observations concerning the expression of E-selectin and IL-2R in alopecia universalis are consistent with the view that extravascular trafficking of MNC into follicular epithelium may play a key role in the pathogenesis of alopecia universalis and that use of agents that interfere with this process may be an effective therapeutic strategy.
Pseudo-fibrokeratoma of the nail apparatus with melanocytic pigmentation: a clue for diagnosing Bowen's disease.
Authors: Baran R , Perrin C
Published: July 2023

Bowen's disease of the nail apparatus is a protean condition where pseudo-fibrokeratoma associated with melanocytic pigmentation was the clue leading to the clinical diagnosis. Migration of melanocytes into the superficial layers of the matrix epithelium may be associated with the extension of the epidermal tumoral process, without necessitating a real melanocytic hyperplasia.
Spontaneously regressing malignant melanoma with unusual histological features.
Authors: Tamura A , Ishikawa O , Miyachi Y
Published: July 2023

An 85-year-old man with spontaneously regressing primary malignant melanoma is reported. Histological features were considered to be compatible with those of spontaneously regressing malignant melanoma, except that many multinucleated giant cells were observed replacing typical melanoma cells.
Experience with the murine local lymph node assay: inability to discriminate between allergens and irritants.
Authors: Montelius J , Wahlkvist H , Boman A , Fernström P , Gråbergs L , Wahlberg J E
Published: July 2023

The murine local lymph node assay is a new predictive test for identifying contact sensitizers. It measures the proliferative response in the lymph nodes during the sensitization phase. In the present study, moderate-to-extreme allergens (from human and guinea pig experience) gave clearly positive results in this assay. However, irritants tested, i.e. sodium dodecyl sulphate (SDS), chloroform/methanol, oxalic acid, triton X-100 and methylsalicylate, also gave positive results, not distinguishable from the results with low-grade/moderate allergens. Two allergens were also tested in the presence of 10% SDS. The effect on proliferation was additive in the first case and synergistic in the second. The local lymph node assay in its present design and with the criteria used for a positive response requires further validation studies and perhaps further development before it can be accepted as an alternative to guinea pig tests for allergenicity. Substances with exclusively irritating properties could falsely be classified as allergens by the method or, alternatively, the allergenicity of chemicals with both allergenic and irritating properties could be overestimated.
Long-term topical nitrogen mustard treatment does not induce pulmonary fibrosis in MF patients.
Authors: Nielsen M , Rasmussen K , Knudsen N , Thestrup-Pedersen K
Published: July 2023

Eleven patients with mycosis fungoides had X-ray examinations of their lungs before, during and after topical treatment with mechlorethamine. The mean number of treatments was 163, ranging from 28 to 300 treatments within a period of 1 to 13 years (mean 7.8 years). Each exposure to the skin of mechlorethamine was between 20 and 40 mg giving a cumulative dosage in the range from 1.120 mg to a maximum of 12.000 mg. We looked for potential lung damage from mechlorethamine vapours, such as fibrosis of the lungs, but found none. Thus, we conclude that topical treatment with mechlorethamine of patients with mycosis fungoides is not only an effective treatment, but also a safe therapy.
Evaluation of in vitro functional activity of ANB4 drug for the treatment of spinal muscular atrophy
Authors: Rodenkov Evgeny M. , Kozhemyakina Natalya V. , Zonis Yulia A. , Gershovich Pavel M. , Lalaev Boris Yu.
Published: July 2023

BACKGROUND: Spinal muscular atrophy (SMA) is a monogenic neurodegenerative disease. SMA is caused by a deficiency of the functional survival motor neuron protein (SMN) as a result of a mutation in the SMN1 gene. BIOCAD is developing a domestic gene therapy drug for the treatment of SMA based on recombinant adeno-associated virus serotype 9 (rAAV9) carrying the SMN1 gene (ANB4). In vitro evaluation of the functional activity of ANB4 will allow a more complete characterization of the drug.
AIM: Development of an accurate and reproducible in vitro functional test that reflects the clinical mechanism of action of ANB4.
METHODS: To model SMA, the SMN1 gene was knocked down by transfection with small interfering RNA. Amount of the SMN protein was measured by enzyme-linked immunosorbent assay. The functional activity of the drug was evaluated by analysis of Gemin2 protein level using the western blot analysis.
RESULTS: Analytical method has been developed to assess the functional activity of the ANB4 drug for the treatment of SMA type 1 (rAAV9 carrying the SMN1 gene). The developed technique made it possible to obtain accurate and reproducible results. Production of Gemin2 after knockdown of SMN1 and the introduction of exogenous SMN1 gene was restored to control values, comparable with the restoration of the level of the SMN protein.
CONCLUSION: The developed technique closely reflects the clinical mechanism of action of the ANB4 drug for the treatment of SMA. By evaluating the functional activity in vitro, accurate and reproducible results were obtained in accordance with the required standards, including the principles of 3R.
Students Responses to New Learning Environmental Using Canva Application at the Newton Law’s
Authors:   PPG Prajabatan Gelombang 1 Biologi Universitas PGRI Semarang, Shabrina Kenya Luthfia Nur , Hayat Muhammad Syaipul ,   Lecturer in Magister Department Natural Science, PGRI University of Semarang, Semarang, Indonesia, Mulyaningrum Eko Retno ,   Lecturer in Magister Department Natural Science, PGRI University of Semarang, Semarang, Indonesia, Sularni Endang ,   Teacher in Junior High School 37 Semarang, Semarang, Indonesia
Published: July 2023

The purpose of this study is to find out students' responses to the New Learning Environmental program using the Canva application on Newton's law material. Based on the results of observations and interviews conducted in SMP Negeri 37 Semarang, it assumes a new learning environment or learning innovation to improve students' skills and students' understanding of Newton's law material. This study used a descriptive qualitative method in conducting observations and interviews. Class VII C was used as a sample. The results of the new learning environment were several answers in the training lessons on using the Canva application, which was helpful in the tasks in the form of products about Newton's law (infographics, mind mapping, posters, and videos) of material. During the learning, the students are very enthusiastic, free to be creative, and even free to change seats while learning. Based on this, it can be concluded that the New Learning Environment supported by the Canva application of Newton's law material received a positive responses from the students during the learning process.
Potential Use of Water Hyacinth (Eichhornia Crassipes), to Reduce Production Cost in Tilapia Culture at Small and Median Scale
Authors: Reyes J. Guillermo Galindo , Alegria Henry
Published: July 2023

Tilapia farming is increasing in the US, Mexico and other countries; but anywhere, the cost of food is the big problem. Therefore, to reduce production costs, the water hyacinth aquatic plant, was used as a food supplement. Dehydrated water hyacinth was assorted with cane molasses and anaerobically fermented with (Lactobacillus sp.). The fermented product was mixed with cornmeal and commercial food (Purina®), at proportions of 30-20-50 respectively. Then mixture was extruded and dried, to be used as a feed supplement for tilapia. Juveniles tilapia between 5-7 g were obtained from a commercial hatchery and fed with Purina®, until fishes reached 24-26 g; then, tilapias were separated into two groups; the experimental and the control groups. The experimental group, 40 tilapias, was transferred to a 4032 L pond, while control group,15 tilapias were distributed in 5 ponds of 300 L; in this way, the socking density was around (10 fish/m3) in all ponds. The experimental group was fed with water hyacinth supplemented food, while the control group with Purina®. Tilapia from both groups were weighed every 2 weeks for 3 months; moreover, the water quality parameters pH, O2, T (oC), TSS and total ammonia were recorded in all the ponds. To know the tilapia growth from both groups, several growth parameters, such as: weight gain, relative growth rate, feed conversion ratio and specific growth rate were calculated. Results showed that tilapia weight gain fed with supplemented water hyacinth food, was 8.6 % higher than tilapias fed, with Purina®. Also, the food cost of tilapias fed with water hyacinth supplemented feed, were 15.37 % lower than tilapia fed with Purina®. Therefore, it can be concluded that tilapia aquaculture at small and medium scale, can developed satisfactorily using water hyacinth supplemented feed.
ISSUES AND CHALLENGES OF TECHNOLOGY USE IN INDONESIAN SCHOOLS: IMPLICATIONS FOR TEACHING AND LEARNING
Authors: Gai Mali Yustinus Calvin , Kurniawan Daniel , Januardi Josephine Ilona , Swara Sanditya Jati , Lokollo Natalia Christy Emy , Picauly Irma Amy , Paramitha Nathasa Gracia , Tanore Jose Argo , Dewani Meta Sekar , Pakiding Risdy Wijaya
Published: July 2023

This paper mainly aims to explore issues and challenges in using technology to support teaching and learning in various schools located on three different islands in Indonesia, such as in Kalimantan, Nusa Tenggara, and Papua islands. The exploration was done through a holistic literature review of 30 national and local newspapers and online articles relevant to the aim of the study. We performed a peer-debriefing activity to present our review analysis to each other, comment on it, and made necessary revisions to our analysis to ensure the credibility of our review. While the results communicated various things, we could highlight some commonalities: unequal distribution of technology support or facilities in schools, creative ways to support teaching and learning practices regardless of the very minimum facilities that schools have, and continuous support from the Indonesian government and private sectors to improve school technology-supported facilities. We then discussed those commonalities in light of the relevant literature and their implications for teaching and learning to benefit school teachers or educational practitioners planning to teach in schools outside Java with minimal technological-related school facilities.
EVALUASI AUGMENTED REALITY BANGUN RUANG SEBAGAI MEDIA PEMBELAJARAN SISWA KELAS IV SEKOLAH DASAR
Authors: Umri Buyut Khoirul , Astuti Ika Asti , Sholihan Achmad Choirul
Published: July 2023

Model pembelajaran menggunakan metode ceramah masih digunakan dalam pelajaran matematika pada materi bangun ruang di SD Muhammadiyah Noyokerten kelas IV. Dalam mempelajari bangun ruang, siswa dituntut memiliki imajinasi yang tinggi serta konstentrasi yang mendalam dalam mendeskripsikan unsur-unsur bangun ruang (sisi, sudut, jaring, tepi). Salah satu metode yang dapat digunakan untuk membantu visualisasi bangun ruang yakni menggunakan teknologi Augmented Reality. Penelitian dimulai dengan melakukan analisis masalah pada SD Muhammadiyah Noyokerten kelas IV, melakukan perancangan sistem, coding program hingga testing. Testing yang dilakukan meliputi black box atau menguji fungsionalitas aplikasi, validasi kepada 2 ahli materi dan uji coba kepada 31 siswa. Hasil uji black box menandakan bahwa fungsional aplikasi telah berjalan dengan baik. Hasil validasi kepada ahli materi menandakan bahwa aplikasi reliable untuk digunakan. Kebergunaan aplikasi dinilai dengan membandingkan hasil belajar pemahaman materi siswa dari model pembelajaran ceramah (pretest) dan menggunakan aplikasi augmented reality (post test) yang dikembangkan. Hasil uji siswa menunjukan bahwa nilai rata-rata pretes adalah 49.68 dan rata-rata nilai post test adalah 74.84. Hal ini berarti ada peningkatan hasil belajar materi bangun ruang sesudah menerapkan media pembelajaran dengan teknologi augmented reality.
Online Asynchronous Learning English for Specific Purposes Terminology
Authors: Kolomiiets Svitlana , Guryeyeva Lyudmyla , Kulieznova Svitlana
Published: July 2023

The pandemic and military actions in the country triggered our study in considering the challenges Ukrainian higher education faces referring asynchronous learning. We assume that the challenges are threefold – namely – psychological, technical (availability of means for providing asynchronous communication and technological (scientifically grounded methods of quality asynchronous learning). In our study the focus is on the methods of asynchronous learning specialized terminology. The background of the research was the study of the literature concerning benefits and limitations of asynchronous learning and implementing online courses into the learning process. The purpose of this research was to prove the effectiveness of asynchronous learning specialized vocabulary with the help of the Moodle-based course. The aim was achieved by fulfilling the following tasks: literary review to study the benefits and limitations of asynchronous and synchronous learning for finding the most suitable mode of communication for the Ukrainian students, to design a Moodle-based course, to verify it in the experimental learning. The experiment was conducted in 2020 in the time of Covid-19 pandemic at the National Technical University of Ukraine, Igor Sikorsky Kyiv Polytechnic Institute, and involved seventy students of the Power Engineering Department. The research purpose of both the article and the experiment was to assess the effectiveness of the developed online simulator which included audio recordings of native English specialists’ communication, interdisciplinary and industry-specific terminology, training tasks, and instructional guidelines. The outcome of the research proves the efficiency of applying an online simulator in the development of students’ professional competence in terms of adequate using interdisciplinary and industry-specific terminology.
Condições do Ensino Médio para a oferta de itinerários formativos no Brasil
Authors: Fernandes Edison Flávio
Published: July 2023

O estudo objetiva trazer uma base diagnóstica sobre as condições atuais das escolas de ensino médio no País, bem como de seu professorado, tendo em vista a corrente reforma dessa etapa de ensino, especificamente a oferta de itinerários formativos, de modo a contribuir com os debates no âmbito do novo Plano Nacional de Educação (PNE).

Metodologicamente, são investigados a quantidade e a infraestrutura das escolas que ofertam o ensino médio no Brasil, os níveis de adequação da formação e de esforço dos docentes que mediarão a oferta dos itinerários formativos e a situação do alunado de ensino médio (propedêutico, integrado e normal) em relação ao fluxo e ao rendimento escolar. Como parte de uma sequência de investigações sobre o campo curricular, o estudo volta-se, particularmente, ao estado dos sistemas de ensino médio enquanto receptores de políticas de reforma.

Para a investigação, adotaram-se premissas (não exaustivas) de condições mínimas para um acesso amplo e abrangente aos preconizados itinerários formativos, conforme estabelecido pela legislação afeta, a partir de três ângulos: a infraestrutura escolar, a formação e a valorização do docente e a trajetória escolar dos alunos de ensino médio. As premissas são confrontadas com estatísticas educacionais sobre as condições correntes de oferta do ensino médio no País (com suas desagregações) e sobre o atual estágio das metas do PNE, estimadas no 4º Relatório de Monitoramento do Plano. São utilizadas as bases de dados mais recentes do Censo da Educação Básica, os indicadores educacionais do Instituto Nacional de Estudos e Pesquisas Educacionais (Inep), a Pesquisa Nacional por Amostra de Domicílios (Pnad) Contínua, bem como o corpo normativo relacionado ao corrente Plano Nacional de Educação (PNE 2014- 2024) e à reforma do ensino médio no Brasil após 2016.

Os resultados sugerem que, para além das construções normativo-curriculares, as quais, por si, não garantem o direito e a oportunidade equitativa de acesso ao conhecimento e à experiência escolar, as discussões no âmbito do novo PNE devem perpassar mecanismos de indução e fomento a políticas de promoção de condições estruturais mínimas nas escolas e de condições de trabalho e de valorização docente que respaldem, ex ante, qualquer iniciativa política no campo curricular. Nesse sentido, identifica-se a premência de um novo PNE que recupere e avance em objetivos, metas e estratégias voltados à infraestrutura das escolas de ensino médio e à valorização, à atratividade e ao respeito à carreira docente. A discussão e formulação do Plano, entende-se, reclamam a direta participação da comunidade educacional e escolar.
Aldear os planos nacionais de educação
Authors: Barbosa Lima Márcio Alexandre , Dos Santos Robson
Published: July 2023

O estudo busca contribuir com as discussões sobre o novo Plano Nacional de Educação (PNE) no que diz respeito à educação escolar indígena. Inicialmente, faz-se uma comparação entre o desenho adotado no atual PNE (2014-2024) com o daquele que o antecedeu, no tocante à construção das metas e dos objetivos relacionados aos indígenas. Em seguida, analisam-se os resultados alcançados no último Plano com fundamento nos indicadores de monitoramento do PNE. Os dados sinalizam que esses povos apresentam os índices mais críticos em várias metas e, portanto, deveriam ser a referência na elaboração de políticas equitativas. Como conclusão, o trabalho sugere a inclusão de metas e estratégias específicas da educação escolar indígena no próximo Plano, baseadas nas demandas elaboradas nos diversos Fóruns de Educação Escolar Indígena e na experiência adquirida por meio do monitoramento do atual PNE.
Los dilemas de las redes criminales de Bello
Authors: Castañeda Blandón César Giovanny
Published: July 2023

Durante las cuatro décadas anteriores las redes criminales del municipio de Bello crecieron y sofisticaron sus estructuras y repertorios criminales, convirtiéndose en estructuras mafiosas con amplio dominio territorial, capaces de constreñir a gran parte de la ciudadanía mediante la imposición de tributos criminales, creando monopolios comerciales en mercados legales e ilegales, y alimentando redes de corrupción para quitarle efectividad a la política pública de seguridad. Luego de identificar y establecer las motivaciones económicas y los repertorios de las redes delincuenciales analizadas, mediante el uso de las herramientas analíticas de teoría de la agencia, se establecieron algunas de las vulnerabilidades que afloraran cuando sus dirigentes enfrentan los dilemas surgidos de la relación agente-principal. Los diseñadores de la política pública de seguridad, podrían derivar importantes líneas de acción que exploten las vulnerabilidades de los criminales en pos de la tutela material de los bienes jurídicos de la comunidad bellanita.
Criminología del Desarrollo: estudio del desarrollo en la formación de la conducta criminal
Authors: Hikal Carreón Wael Sarwat
Published: July 2023

La aplicación de la Criminología en los diferentes problemas sociales afines con el delito es necesaria con el propósito de entender, explicar y abordar un fenómeno particular. Cotidianamente esta ciencia ha sido desplazada o subdelegada a otra superior, como al Derecho, Psicología, Medicina u otras. En el presente artículo se propone la sistematización de estudios relacionados con el desarrollo humano con un enfoque criminológico, con la finalidad que la Criminología recoja y reúna los conocimientos a las etapas del desarrollo para llegar al entendimiento criminal para su tratamiento clínico, así como preventivo social. Dicha propuesta consiste en una Criminología del Desarrollo, para lo cual en las siguientes líneas, se colocan marcos de referencia para sentar las bases de los estudios en esta área. Este trabajo se divide en cuatro partes, introducción al desarrollo y la conducta, factores que influyen en el desarrollo tanto general como criminal, la especialización de la Criminología, y estudiosos del desarrollo criminal.
Fundamentación doctrinaria y axiológica de las sentencias penales del derecho en el poder judicial de Pasco, Perú
Authors: Paucar Coz Degollación Andrés , Rimac Ventura Estelita
Published: July 2023

La investigación tiene por objetivo realizar un examen crítico y dogmático sobre la importancia de la fundamentación doctrinaria y axiológica de las sentencias penales, en la época de la supremacía de la Constitución, la constitucionalización de las normas penales y el empleo de la hermenéutica constitucional en el razonamiento judicial. La investigación fue de tipo descriptiva, el enfoque del problema en estudio ha sido efectuado desde la teoría del derecho penal garantista, que trata de restringir la violencia intrínseca del sistema penal, para limitar su intervención a las funciones manifiestas de la pena establecidas en el Art. IX del Título Preliminar: preventiva, protectora y resocializadora, que el Estado peruano le asigna a la sanción penal, en el marco jurídico y político del Estado democrático de Derecho, sustentado en la doctrina neo constitucional y el paradigma de los derechos fundamentales. La dignidad es la cualidad ontológica de la persona que lo distingue como ser superior racional, libre, consciente de sí mismo, de su finitud y su grandeza, capaz de valorar, optar, decidir y por consiguiente asumir la responsabilidad de sus actos, afirmándose que es el único ser que no tiene precio porque no tiene equivalente.
PERANCANGAN TURBIN AIR TIPE OVERSHOT SEBAGAI PROTOTIPE PEMBANGKIT LISTRIK TENAGA MICROHIDRO DI SUNGAI RAHTAWU
Authors: Kurnia Rizaldi , Wibowo Rianto , Hudaya Akhmad Zidni
Published: July 2023

Kebutuhan energi listrik Indonesia semakin meningkat seiring dengan pertumbuhan jumlah penduduk dari tahun ke tahun. Pembangkit Listrik Negara (PLN) berusaha semaksimal mungkin untuk memenuhi kebutuhan energi listrik. Namun nyatanya saat ini masih banyak warga Indonesia yang belum menikmati energi listrik terutama warga pedesaan yang jauh dari jangkuan listrik Negara. Pembangkit Listrik Tenaga Mikro Hidro (PLTMH) merupakan bagian dari Pembangkit listrik Tenaga Air (PLTA) dimana energi air (potensial kinetik) sebagai sumber energi/daya dengan kapasitas daya terbangkitkan antara 2 kW sampai dengan 200 kW. Penulisan tugas akhir ini bertujuan untuk mengetahui proses perancangan desain turbin air tipe overshot dengan sudu lengkung untuk pembangkit listrik dan mengetahui nilai torsi turbin yang dihasilkan dengan penerapan turbin air sumbu horizontal tipe overshot dengan sudu lengkung.Metode yang di gunakan untuk peracangan turbin air ini adalah dengan perhitungan jumlah sudu aktif, perhitungan jarak antar sudu dan perhitungan diameter poros kincir.Sehingga hasil perancangan berupa gambar kerja yang bisa digunakan sebagai pedoman untuk pembuatan turbin overshot.Kata kunci : Energi Air, Turbin Overshot, Sudu Lengkung, Microhidro
RANCANG BANGUN POMPA AIR SISTEM AKSIAL
Authors: Alatas Zelimkhan Yanderbiyev , Wibowo Rianto , Slamet Sugeng
Published: July 2023

The pump is a very important tool for various necessities of life, including fish farming activities. The selection of the wrong type of pump can result in large costs, so knowledge and skills are needed about pumps and their use. The background of the research is the need for the type of pump that is in accordance with the conditions in the field, especially for the use of fish farming. The initial step of this research is the calculation of the pump dimensions, followed by the fabrication process / component manufacture according to the calculations that have been done. The final stage of the research is the assembly and testing process. The calculation phase results in the dimensions of the pump with an impeller diameter of 45.9 mm and a hub diameter of 21.5 mm, as well as a number of 8 blades. The pump will operate at 1200 rpm with a flow rate of 42 liters/minute with a max head height of 1.2 meters. In the final stage of testing, the pump operates with a flowrate of 40 L/m and a maximum head of 1 meter. The actual discharge and head of the pump are different from the design value caused by the impeller dimensions that are still not suitable, causing the pump head to drop
ANALISA PENGGANTIAN SILINDER LINER ALMUNIUM SILICON DENGAN SILINDER LINER BESI COR PADA SILINDER BLOK MESIN SEPEDA MOTOR 4 LANGKAH DENGAN KAPASITAS MESIN 113.69 CC
Authors: Prabowo M Aris , Setiyono Setiyono
Published: July 2023

Silinder blok adalah komponen yang merupakan satu kesatuan dari silinder liner. Fungsi                        utama dari silinder blok adalah untuk menopang semua bagian-bagian utama mesin seperti piston, kepala silinder, jalur pelumasan ke silinder head, poros engkol dan sekaligus sebagai media pendingin mesin. Pada umumnya silinder blok pda mesin terbuat dari bahan almunium karena almunium memiliki sifat yang kuat, ringan serta mudah menghantarkan panas, sehingga panas hasil pembakaran di dalam silinder liner bisa di transfer ke luar. Metode ini memperbandingkan nilai kekerasan dari silinder liner. Lalu dilakukan pengujian komposisi kimia, kekerasan dan mikro struktur. Terbukti bahwa material besi cor lebih keras dari pada aluminium silokon dari nilai kekerasannya.
PENERAPAN METODE TOPSIS DALAM SISTEM PENGAMBILAN KEPUTUSAN PEMBERIAN BANTUAN REHABILITASI RUMAH
Authors: Letelay Kornelis , Mola Sebastianus A.S , Snae Derwinta Pondence
Published: July 2023

The provision of assistance for the rehabilitation of uninhabitable houses to the community often results in fraud and errors in the process of selecting and providing assistance. The TOPSIS method is a method used to calculate in the decision-making process in determining prospective recipients of uninhabitable housing rehabilitation assistance. The results of the TOPSIS calculation from the system were then tested using the sensitivity test method by giving a weight change of 0.5 and 1 for each criterion weight. The test results in 2019 with a total of 25 families of data obtained the most sensitive criteria for adding a weight of 0.5, namely the criteria for work and life dependents with a percentage result of 92%, while for adding weight to 1 the most sensitive criterion is the job criteria with a percentage result of 96%. Black box testing of the system built is measured using a questionnaire media with 10 statement items given to 15 respondents which is calculated using a Likert Scale where the system built is highly approved which can be seen from the index percentage value greater than 80% (strongly agree).
Penerapan Model Pembelajaran Kreatif Produktif Untuk Meningkatkan Aktifitas Belajar Mahasiswa Melalui Lesson Study Di Program Studi Pendidikan Pancasila Dan Kewarganegaraan
Authors: Sawaludin Sawaludin , Muttaqin Zedi , Sina Sina , Saddam Saddam
Published: July 2023

This activity includes lesson study activities developed with three cycles through three stages, namely plan, do and see. This activity aims to improve student learning activities through the application of productive creative learning models. This activity was carried out in the fifth semester Pancasila education and citizenship education program Muhammadyah Mataram University, three cycles or three meetings (3 x 90 minutes), on the topics of learning theories, learning media, and information technology. From the results of the activity data it can be concluded that, the stages of productive creative learning that have been applied have succeeded in increasing student learning activities. This is because, all stages of learning activities emphasize the involvement of students from the beginning to the end of learning. Besides that, lecturers position themselves as facilitators and facilitators that are good for student learning activities. The implementation of the lesson study during the activity also strengthened the legality between the LS team, formed mutual learning (mutual learning), and increased the professionalism of lecturers as educators and instructors.