bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Ga Incorporation in TiO2/SnO2 Nanoparticle‐Decorated Hierarchical ZSM‐5 Composite as Precious‐Metal‐Free Electrocatalysts for Oxygen Electro‐Reduction
Authors: Mashola Tebogo Abigail , Mugadza Kudzai , Matthews Thabo , Msomi Phumlani Fortune , Maxakato Nobanathi Wendy
Published: January 2024

The slow nature of oxygen electro‐reduction has become a major obstacle in fuel cell commercialization. Researchers have recently focused on developing efficient electrocatalysts to address this issue. In this study, we investigated the catalytic activity of electrocatalysts based on metal‐incorporated zeolites. We prepared the zeolite socony mobil‐5 (ZSM‐5) zeolite samples hydrothermally and modified them to introduce mesopores and metal nanoparticles. The metal nanoparticles were supported on the hierarchical zeolite socony mobil‐5 (HZSM‐5) support materials by ion‐exchange process. Surface morphology analysis revealed that the pristine material had a smooth surface which became rough upon post‐modification of the material. Hierarchical zeolites showed large surface area and pore volume. The TiSn‐loaded‐HZSM‐5 demonstrated higher catalytic efficiency than other prepared electrocatalysts for ORR. The catalytic efficiency of the synthesized electrocatalysts was in the order TiSn‐HZSM‐5>GaSn‐HZSM‐5>TiGaSn‐HZSM‐5>TiGa‐HZSM‐5 with the onset potential of 0.86, 0.81, 0.80 and 0.78 V respectively. Catalysis is affected by the size, dispersion and electronic state of metal nanoparticles as observed by the catalytic efficiency of the trimetallic electrocatalysts which have low catalytic activity compared to bimetallic counterparts. Bimetallic hierarchical zeolites based electrocatalysts have great potential in catalysis, but there is still room for improvement.
Effects of Anions and Surface Structure on Pt Single Crystal Dissolution in Acidic Electrolytes
Authors: Briega‐Martos Valentín , Fuchs Timo , Drnec Jakub , Magnussen Olaf M. , Cherevko Serhiy
Published: January 2024

Understanding the mechanisms of Pt dissolution with well‐defined surfaces is vital for developing stable catalysts for electrochemical energy conversion devices such as fuel cells. This work investigates Pt dissolution from low‐index single crystals in perchlorate, sulfate, and methanesulfonate acid solutions by on‐line inductively coupled plasma mass spectrometry (ICP‐MS), and the results are correlated with surface X‐ray diffraction (SXRD) studies. The previously reported stability trend Pt(111)>Pt(100)>Pt(110) in HClO4 was confirmed for the other acids. The application of electrochemical protocols up to high potential values demonstrated that dissolution for Pt(100) increases to a lower extent than for the other planes. Dissolution is affected by the nature of the anion, especially for Pt(111), with the dissolution rate increasing in the order H2SO4>MSA>HClO4. This influence could be due to the interaction strength of the anion with Pt and its complexing ability or different ratios of the surface coverage of different oxide species. For Pt(111), SXRD measurements show different onset potentials for extraction in HClO4 and H2SO4, which can influence the dissolution processes. These results demonstrate that fundamental studies are necessary to improve the current knowledge about Pt dissolution and how to hinder it to a practical extent.
Effects of flaxseed supplementation on weight loss, lipid profiles, glucose, and high‐sensitivity C‐reactive protein in patients with coronary artery disease: A systematic review and meta‐analysis of randomized controlled trials
Authors: Sabet Hamid Reza , Ahmadi Mohammad , Akrami Mehdi , Motamed Mahsa , Keshavarzian Omid , Abdollahi Mozhan , Rezaei Mehdi , Akbari Hamed
Published: January 2024

This meta‐analysis aimed to evaluate the effects of flaxseed supplementation on weight loss, lipid profiles, high‐sensitivity C‐reactive protein (hs‐CRP), and glucose levels in patients with coronary artery disease (CAD). A systematic search was performed using various online databases, including Scopus, PubMed, Web of Science, EMBASE, and Cochrane Library, to identify relevant randomized controlled trials (RCTs) until June 2023. To evaluate heterogeneity among the selected studies, the Q‐test and I2 statistics were employed. Data were combined using either a fixed‐ or random‐effects model and presented as a weighted mean difference (WMD) with a 95% confidence interval (CI). Of the 428 citations, six RCTs were included. The pooled results did not show significant changes in the WMD of lipid factors (high‐density lipoprotein cholesterol, triglycerides (TG), low‐density lipoprotein cholesterol, and total cholesterol) following flaxseed intake. However, after performing a sensitivity analysis to determine the source of heterogeneity, flaxseed supplementation resulted in a significant decrease in TG levels (WMD = −18.39 mg/dL; 95% CI: −35.02, −1.75). Moreover, no significant differences were observed in either weight or BMI following flaxseed intake. However, the circulating levels of fasting blood glucose (WMD = −8.35 mg/dL; 95% CI: −15.01, −1.69, p = .01) and hs‐CRP (WMD = −1.35 mg/L; 95% CI: −1.93, −0.77, p < .01) significantly decreased after the intervention. Flaxseed supplementation was associated with lowering FBS, hs‐CRP, and TG levels but did not affect weight loss parameters and other lipid markers in CAD.
Sustainable Electrochemical Benzylic C−H Oxidation Using MeOH as an Oxygen Source
Authors: Xue Meng , Pan Tao , Shao Zhichao , Wang Wenxuan , Li Hu , Zhao Lixing , Zhou Xin , Zhang Yuexia
Published: January 2024

New methods and strategies for the direct oxidation of benzylic C−H bonds are highly desirable, owing to the importance of ketone motifs in significant organic transformations and the synthesis of valuable molecules, including pharmaceuticals, pesticides, and fine chemicals. Herein, we describe an electrochemical benzylic C−H oxidation strategy for the synthesis of ketones using MeOH as an oxygen source. Inexpensive and safe KBr serves as both an electrolyte and a bromide radical precursor in the reaction. This transformation also offers several advantages such as mild conditions, broad functional group tolerance, and operational simplicity. Mechanistic investigations by control experiments, radical scavenging experiments, electron paramagnetic resonance (EPR), kinetic studies, cyclic voltammetry (CV), and in‐situ Fourier transform infrared (FTIR) spectroscopy support a pathway involving the formation and transformation of benzyl methyl ether via hydrogen atom transfer (HAT) and single‐electron transfer (SET). The practical application of our strategy is highlighted by the successful synthesis of five pharmaceuticals, namely lenperone, melperone, diphenhydramine, cinnarizine, and flunarizine.
The term structure of interest rates and economic activity: Evidence from the COVID‐19 pandemic
Authors: Salachas Evangelos , Kouretas Georgios P. , Laopodis Nikiforos T.
Published: January 2024

This paper tests the accuracy and predictability of two term structure models using both yields‐only and factor‐augmented specifications focusing on the recent COVID‐19 crisis. In addition, we test the predictive ability of the yield curve on economic activity for the United States and other advanced countries. We provide evidence that models with an enhanced information set, including COVID‐19 factors, improve interest rate forecasts for this period. Also, we point out that term structure models can determine future variations in economic activity but are time‐ and country‐sensitive. Finally, out‐of‐sample analysis reveals that the use of factor‐augmented term structure models, to reflect the current economic and market conditions, improves their forecasting accuracy.
Fractional order capacitance behavior due to hysteresis effect of ferroelectric material on GaN HEMT devices
Authors: Pyngrope Dariskhem , Majumdar Shubhankar , Crupi Giovanni
Published: January 2024

In recent years, gallium nitride (GaN) high electron mobility transistors (HEMTs) have come to the forefront of the semiconductor industry because of their exceptional performance in both high‐power and high‐frequency utility. Accurate capacitance modeling is crucial to optimize performance and facilitate energy‐efficient electronic circuit design. In order to reflect the complex nature of the aluminum scandium nitride (AlScN) gate capacitance in GaN HEMTs this study investigates the use of the unique Grünwald‐Letnikov model based on fractional order calculus. The proposed model presents a powerful approach to accurately characterize capacitance since fractional order derivatives allow modeling of non‐integer order systems. Quantitative assessment of the Grünwald‐Letnikov model's accuracy is performed through various error metrics, including mean absolute error (MAE), root mean square error (RMSE), maximum percentage error (MPE), mean absolute percentage error (MAPE), and mean squared error (MSE), by comparing the model's predictions to experimental data. Notably, this model demonstrates remarkable consistency in error metrics, with maximum values of MPE = 0.21%, MAE = 0.05%, MAPE = 0.33%, MSE = 0.01%, and RMSE = 0.09% for the forward scan, and MPE = 0.32%, MAE = 0.04%, MAPE = 0.39%, MSE = 0.01%, and RMSE = 0.08% for the backward scan. These metrics affirm the model's precision in capturing the nuanced capacitance characteristics of GaN HEMT devices. Hence, herein for the first time, the novel Grünwald‐Letnikov model, augmented by fractional order calculus, proves to be a robust tool for accurately characterizing GaN HEMT capacitance. Its ability to seamlessly account for the complexities introduced by using ferroelectric material highlights its potential for advancing semiconductor design and optimizing device performance.
Negative effects of COVID‐19 on the implantation rate of cardiac resynchronization therapy with defibrillator device
Authors: Johal Anmol , Udongwo Ndausung , Imburgio Steven , Mararenko Anton , Akhlaq Hira , Dandu Sowmya , Abe Temidayo , Almendral Jesus , Heaton Joseph , Hansalia Riple
Published: January 2024

Introduction

COVID‐19 drastically impacted the landscape of the United States’ medical system. Limited data is available on the nationwide implantation trends in Cardiac Resynchronization Therapy Defibrillator (CRT‐D) devices before and during the pandemic. We aimed to explore the impact of the COVID‐19 pandemic on CRT‐D insertion rates and adverse outcomes related to delays in care.

Methods and Results

We conducted a retrospective cross‐sectional analysis using the National Inpatient Sample database between 2017 and 2020. Variables were identified using their ICD‐10 codes. Inclusion criteria: age ≥ 18 years, presenting for a nonelective admission, primary diagnosis of hypertensive heart disease, hypertensive heart, chronic kidney disease, or heart failure, and underwent insertion of a CRT‐D. Between 2017 and 2020, CRT‐D devices were inserted during 23,635 admissions. On average, 6198 devices were implanted yearly from 2017 to 2019, with only 5040 devices being implanted in 2020. Additionally, reduced implantation rates were noted for every cohort of hospital size, location, and teaching status during this year. The year 2020 also had the highest average death rate at 1.39%, but this difference was statistically insignificant (adjusted Wald test p = .767), and COVID‐19 was not associated with an increased risk of inpatient mortality (OR 0.22, 95% CI 0.03–1.82, p = .162).

Conclusion

The COVID‐19 pandemic has affected all facets of the healthcare system, especially surgical volume rates. CRT‐D procedures significantly decreased in 2020. This is the first retrospective study highlighting the trend of reduced rates of CRT‐D implantation as a response to the COVID‐19 pandemic.
Correlation of 3D Morphometric Changes, Kinematics, and Muscle Activity During Smile
Authors: Özsoy Özlem , Özsoy Umut , Yıldırım Yılmaz , Alkan Ege , Yılmaz Beste , Güllü Selin Esma
Published: January 2024

Objective

Knowing the morphological, kinematic, and electrophysiological parameters of the smile in healthy individuals may contribute to evaluating, planning, and monitoring the smile reanimation. This study aimed to determine the correlation between 3D morphometric changes, movement kinematics, and muscle activity in the facial soft tissue of healthy individuals.

Method

In this cohort study, 20 volunteers were selected from healthy individuals with no facial disorders. During smiling, three‐dimensional face scanning, facial motion capture, and surface electromyography (sEMG) were performed. The average displacement, velocity, and acceleration during facial movements were measured. The mean change in 3D surface morphometry and activation of the zygomaticus major were determined.

Results

The volunteers, comprising 10 males and 10 females, had a mean age of 24 ± 10 years; for female, mean age was 23 ± 5 years and for men 26 ± 13 years. Significant correlations were found between kinematic and morphometric data (r = 0.51, p < 0.001), sEMG and morphometric (r = 0.50, p < 0.001) data, and sEMG and kinematic data (r = 0.49, p < 0.002). The maximum acceleration occurred during approximately 65% of the muscle activation time and 64% of the peak muscle activation value. Additionally, the maximum velocity was reached at around 73% of the muscle activation time and 67% of the peak muscle activation value. Furthermore, the maximum displacement values were observed at approximately 88% of the muscle activation time and 76% of the peak muscle activation value.

Conclusion

The findings may provide insights into the smile's functional parameters, contribute to understanding facial muscle‐related disorders, and aid in improving the diagnosis and treatment of the smile.

Level of Evidence

NA Laryngoscope, 134:3112–3119, 2024
Enhanced Temperature Sensing by Multi‐Mode Coupling in an On‐Chip Microcavity System
Authors: Wang Xueyi , Yuan Tingge , Wu Jiangwei , Chen Yuping , Chen Xianfeng
Published: January 2024

The microcavity is a promising sensor platform, but any perturbation will disturb its linewidth, cause resonance shift or splitting. However, such sensing resolution is limited by the cavity's optical quality factor and mode volume. Here, an on‐chip integrated microcavity system is proposed and demonstrated that the resolution of a self‐referenced sensor can be enhanced with multi‐mode coupling. In experiments, inter‐mode coupling strength is carefully optimized with a pulley waveguide and observed a resolution improvement of nearly 3 times in the frequency domain. While experiencing small refractive index change tuned by temperature, mode‐coupled system shows a 7.2 times sensitivity enhancement that is than the uncoupled system on the same chip and a very significant lineshape contrast ratio change as great reference for minor frequency shifts. This approach will help design microcavity sensors to improve detection sensitivity and resolution under limited manufacture precision.
Carbon enhanced cementitious coatings: Alternative anode materials for impressed current cathodic protection systems intended for reinforced concrete
Authors: Jansson Helen , Zhang Xiaoyan , Ye Lilei , Tang Luping , Mohammadi Amir Saeid , Babaahmadi Arezou
Published: January 2024

In this study, the functionality of self‐formulated carbon‐based conductive coatings (CBCCs) with incorporation of graphite as the anode in an impressed current cathodic protection system is studied. The anode materials are tested and evaluated for long‐term durability and performance by an accelerated durability test method. The results show that the functional time is highly dependent on the acceleration factor, and thus the charge passed through the material during testing, as well as the material composition. From the results, there are also indications that the addition of graphene into the CBCC matrix has a positive effect on the homogeneity of the material, but without any major influence on the conductivity and performance.
Dual octonions and rigid body kinematics
Authors: Çakır Hasan , Bektaş Özcan , Yılmaz Ruşen
Published: January 2024

In this paper, we first give the basic information about octonions and present the Euclidean rotation matrix formed by an octonion in seven‐dimensional Euclidean space. Next, we define and introduce the
‐module and dual vectors using dual numbers. Then, we provide the transformation that maps the points on the unit dual sphere one‐to‐one with the directed lines in
. We also define a subset of the unit dual sphere, demonstrating that each element of this subset corresponds to two intersecting perpendicular directed lines in seven‐dimensional Euclidean space. Following that, we introduce dual octonions with their basic algebraic properties and examine rigid body (screw) motions in seven‐dimensional Euclidean space using dual octonions. Finally, we define an operator and express that this operator transforms two perpendicular intersecting directed lines in seven‐dimensional Euclidean space into two perpendicular intersecting directed lines.
Numerical study of satellite image quality in the presence of Seidel aberrations
Authors: Alici Kamil B.
Published: January 2024

We present estimated images of a hypothetical satellite system in the presence of Seidel aberrations. We exemplified the effects of defocus, spherical, coma, astigmatism, field curvature, and distortion aberrations. Our analysis methods allow the investigation of aberration effects individually and in any combined form. Thereby, we introduce a potentially rich analysis dimension for the imaging chain, image processing, and image quality analyses. For a number of degrees of aberrations, we provide image estimates, show and quantify how individual (field‐dependent) aberrations would introduce degradations on the satellite images. We got correlation coefficient values for defocus, spherical, coma, astigmatism, field curvature, and distortion aberrations as 0.69, 0.71, 0.66, 0.79, 0.76, and 0.60, respectively. Thereby, we identfied the significance order of Seidel aberrations for this system by using image simulations and image similarity measures.
Shortest path network interdiction with asymmetric uncertainty
Authors: Punla‐Green She'ifa Z. , Mitchell John E. , Gearhart Jared L. , Hart William E. , Phillips Cynthia A.
Published: January 2024

This paper considers an extension of the shortest path network interdiction problem that incorporates robustness to account for parameter uncertainty. The shortest path interdiction problem is a game of two players with conflicting agendas and capabilities: an evader, who traverses the arcs of a network from a source node to a sink node using a path of shortest length, and an interdictor, who maximizes the length of the evader's shortest path by interdicting arcs on the network. It is usually assumed that the parameters defining the network are known exactly by both players. We consider the situation where the evader assumes the nominal parameter values while the interdictor uses robust optimization techniques to account for parameter uncertainty or sensor degradation. We formulate this problem as a nonlinear mixed‐integer semi‐infinite bilevel program and show that it can be converted into a mixed‐integer linear program with a second order cone constraint. We use random geometric networks and transportation networks to perform computational studies and demonstrate the unique decision strategies that our variant produces. Solving the shortest path interdiction problem with asymmetric uncertainty protects the interdictor from investing in a strategy that hinges on key interdictions performing as promised. It also provides an alternate strategy that mitigates the risk of these worst‐case possibilities.
Melanoma of the central nervous system based on neurocutaneous melanocytosis in childhood: A rare but fatal condition
Authors: Abele Michael , Forchhammer Stephan , Eigentler Thomas K. , Popescu Aryana , Maschke Linda , Lohse Judith , Lehrnbecher Thomas , Behnisch Wolfgang , Groll Andreas H. , Jakob Marcus , Bernbeck Benedikt , Brecht Ines B. , Schneider Dominik T.
Published: January 2024

Background

Melanomas of the central nervous system (CNS) based on neurocutaneous melanocytosis (NCM) are exceptionally rare in childhood and have been described only sporadically. Rapidly progressive disease may represent a major challenge for treating physicians, especially given the limited knowledge about this condition. This analysis aimed to increase knowledge about the occurrence and treatment of these malignancies.

Procedure

Data on diagnosis, treatment, and outcome of patients aged 0–18 years with CNS melanoma based on NCM recorded in the German Registry for Rare Pediatric Tumors (STEP registry) were analyzed. Additionally, published case reports on this condition were analyzed.

Results

In STEP, five patients with leptomeningeal melanoma based on NCM were identified, with a median age at melanoma diagnosis of 3.7 years. Various multimodal treatments were performed: (partial) resection (n = 4), irradiation (n = 2), trametinib (n = 3), different cytostatics (n = 2), and anti‐GD2 immunotherapy (n = 1). All patients died between 0.3 and 0.8 years after diagnosis. Including published case reports, 27 patients were identified with a median age of 2.8 years at melanoma diagnosis (range: 0.2–16.6). Fourteen of 16 cases with reported data had a NRAS alteration (88%), particularly NRAS p.Q61K (85%). In the expanded cohort, no patient survived longer than 1 year after diagnosis despite multimodal therapy (including trametinib; n = 9), with a median survival of 0.4 years (range 0.1–0.9).

Conclusions

CNS melanomas based on NCM in childhood are aggressive malignancies without curative treatment to date. Therapeutic approaches must be individualized. Genetic tumor sequencing is essential to improve understanding of tumorigenesis and potentially identify new therapeutic targets.
High‐temperature Mass Spectrometric Study and Modeling of the Thermodynamic Properties of the TiO2‐SiO2‐ZrO2 System
Authors: Shilov Andrey L. , Stolyarova Valentina L. , Lopatin Sergey I. , Vorozhtcov Viktor A. , Kirillova Svetlana A.
Published: January 2024

Development of the advanced materials based on the TiO2‐SiO2‐ZrO2 system is hindered by lack of the information on its thermodynamic properties and phase equilibria. In the present study, the samples in the TiO2‐SiO2‐ZrO2 system were prepared by solid‐state synthesis and analyzed by X‐ray microanalysis, fluorescence, and diffraction techniques. The thermodynamic properties in this system were evaluated by Knudsen effusion mass spectrometric (KEMS) method and optimized within the generalized lattice theory of associated solutions (GLTAS). The main vapor species over the silica‐containing samples vaporized from the tungsten cell at the temperature 1973 K were SiO, O, WO2, and WO3. The vapor over the samples in the TiO2‐ZrO2 system at 2356 K was composed mainly of TiO, TiO2, O, WO2, and WO3. The activity of components in the samples and the partial pressures of the identified vapor species were determined. At 1973 K, the TiO2‐SiO2‐ZrO2 system is characterized by positive deviations from the ideality. The observed weak dependence of the SiO2 activity on the SiO2 content suggests the presence of a broad field of immiscibility on the phase diagram in the concentration range 40–100 mol . % SiO2. The thermodynamic data on the TiO2‐SiO2‐ZrO2 system obtained by KEMS can be of great value for calculation of the phase equilibria.
Multi‐Technique Approach to Identify Potent Antimicrobial Agents from Calotropis procera: Insight into Pharmacophore Modeling, Molecular docking, MD simulation, and DFT Approaches
Authors: Rashid Maryam , Sajjad Neha , Shafiq Nusrat , Parveen Shagufta , Khan Rashid Ahmed , Farooq Ariba , Shahab Muhammad , Dawoud Turki M. , Brogi Simone , Bourhia Mohammed
Published: January 2024

In this research, natural compounds from Calotropisprocera were screened according to their antimicrobial activity against the pathogenic microbes selected as E. coli, S. aureus, Traypanosomabrucei, Moraxella catarrhalis, and Leishmaniaamazonensis. A 3D‐QSAR study was performed that evaluated the correlation of the structural parameters for the antimicrobial activity of the natural compounds which were selected based on their antimicrobial in‐vivo and in‐vitro studies previously. The screened active compounds were further studied by molecular docking to analyze the various interactions between the ligands and target proteins. Molecular docking was also performed with the three FDA‐approved antibiotics Cephalexin, Dicloxacillin, and Levofloxacin, having antimicrobial potential, and their results were compared with the docking results of the hit compounds. Results of ADME/T study of the compounds revealed that the two compounds stigmasterol and caryophyllene oxide are the hit compounds having no toxicity, best values of TPSA and average molecular weight. Validation of the docking results was also carried out by re‐docking as well as by molecular dynamic simulation. DFT study was also carried out to explore the stability and chemical properties of active compounds. Results showed that caryophyllene oxide is the hit compound because of the highest Moldock score with 3VOB protein, better than standard drugs and according to dynamic simulation analysis. Therefore, the derived results in these studies provide crucial information for designing antimicrobial drugs by using natural compounds that have better antimicrobial activity.
Rheological, Physicochemical, Thermal, and Mechanical Properties of Biopolymeric Films Incorporated with Micro‐Holocellulose from Coffee Residues
Authors: Hernández‐Varela Josué David , Chanona‐Pérez José Jorge , Bárcenas Gabriel Luna , Medina Dora Iliana
Published: January 2024

Biopolymeric materials have increased their uses and applications in the past years since more advanced preparations have been implemented to find the best formulation for a particular application. Holocellulose from spent coffee grounds (HOLO‐SCG) is a unique material with scarcely studied peculiarities. A detailed study of the flow behavior, microscopy, thermal, and local mechanical properties needs to be performed on biopolymeric films to open the understanding of polymer responsiveness, which is essential for the final design of the composites when fitting characteristics on macroscopic and microscopic scales are achieved. This manuscript aims to obtain biopolymer blends and films based on chitosan (CS) and polyvinyl alcohol (PVA) and reinforced with micro HOLO‐SCG. It seeks to investigate their compatibility and physicochemical properties in liquid states by rheological measurements and solid states using physicochemical, thermal, and mechanical experiments. The results indicate that the prepared CS : PVA films reinforced with HOLO‐SCG under controlled size provide an excellent biopolymeric structure with enhanced thermal and mechanical properties, which brings a stable product to be used as an alternative plastic due to their noticeable lower wettability. The biopolymeric film could be introduced as a bio‐composite material in food packaging applications in further experiments.
Ultrafast Bi‐Directional Bending Moisture‐Responsive Soft Actuators through Superfine Silk Rod Modified Bio‐Mimicking Hierarchical Layered Structure
Authors: Yu Jing , Xu Zongpu , Wan Quan , Shuai Yajun , Wang Jie , Mao Chuanbin , Yang Mingying
Published: January 2024

Development of stimulus‐responsive materials is crucial for novel soft actuators. Among these actuators, the moisture‐responsive actuators are known for their accessibility, eco‐friendliness, and robust regenerative attributes. A major challenge of moisture‐responsive soft actuators (MRSAs) is achieving significant bending curvature within short response times. Many plants naturally perform large deformation through a layered hierarchical structure in response to moisture stimuli. Drawing inspiration from the bionic structure of Delosperma nakurense (D. nakurense) seed capsule, here the fabrication of an ultrafast bi‐directional bending MRSAs is reported. Combining a superfine silk fibroin rod (SFR) modified graphene oxide (GO) moisture‐responsive layer with a moisture‐inert layer of reduced graphene oxide (RGO), this actuator demonstrated large bi‐directional bending deformation (−4.06 ± 0.09 to 10.44 ± 0.00 cm−1) and ultrafast bending rates (7.06 cm−1 s−1). The high deformation rate is achieved by incorporating the SFR into the moisture‐responsive layers, facilitating rapid water transmission within the interlayer structure. The complex yet predictable deformations of this actuator are demonstrated that can be utilized in smart switch, robotic arms, and walking device. The proposed SFR modification method is simple and versatile, enhancing the functionality of hierarchical layered actuators. It holds the potential to advance intelligent soft robots for application in confined environments.
Use of tannase‐producing bacteria isolated from the rumen to improve the nutritional value of pomegranate peel for fattening lambs
Authors: Chaji Morteza , Jahanara Zahra
Published: January 2024

Background

The use of plants and by‐products, which are containing a high amount of secondary and anti‐nutritional compounds such as tannins, in animal feed is limited. The methods that can reduce these compounds make facilitate their use in animal feed.

Objectives

The aim of this study was to reduce the adverse effects of pomegranate peel (PP) tannin for fattening lambs using the tannase‐producing bacteria.

Methods

Twenty‐one Arabi male lambs (averagely 35 ± 3.8 kg weight and 8 ± 1.0 months age) were used in a completely randomized design with three treatments and seven replications in the present experiment. The experimental treatments included 1 – control diet (CNT, no PP), 2 – diet containing untreated PP (raw PP, UTPP) and 3 – diet containing PP treated with tannase‐producing bacteria (bacteria treating PP, BTPP).

Results

Using UTPP decreased nutrient intake compared to the control and treatment with tannase‐producing bacteria again significantly increased nutrient intake compared to the UTPP (p < 0.05). The digestibilities of organic matter, neutral detergent fibre and acid detergent fibre in the control treatment were significantly higher than UTPP and BTPP and in the BTPP were significantly higher than the UTPP (p < 0.05). The use of UTPP in the diet significantly decreased the pH, ammonia nitrogen concentration and the total protozoa population of the rumen compared to the control (p < 0.05), and treatment with bacteria increased them again. The lowest total protozoa population was observed in UTPP treatments (p < 0.05). The highest concentration of blood glucose was observed in UTPP; however, the highest concentrations of blood urea nitrogen, cholesterol, triglyceride, high‐density lipoprotein (non‐significant) and low‐density lipoprotein were in the control treatment. The effect of experimental treatments on the dry matter consumption of the whole period was significant; however, there was no significant effect on average daily gain, feed conversion ratio, feed efficiency and longissimus muscle colorimetric systems.

Conclusions

Therefore, considering the positive effects of treatment PP with tannin‐degrading bacteria relative to raw PP, using these bacteria is a proper way to reduce tannin, thus improving the nutritional value of PP for ruminants.
Isolation and investigation of external reproduction tract mycoflora in healthy male cats
Authors: Garoussi Massoud Talebkhan , Sharifzadeh Aghil , Khodabakhsh Mahssa , Malmasi Abdol Ali
Published: January 2024

Background

Various infectious agents can infect the male reproductive system.

Objectives

The aims of this study were to provide current data on fungal and yeast flora of the external organs of reproductive system of male short hair cats including penis and prepuce.

Methods

In total 28 samples were taken from external genital system of male stray cats using sterilised cotton swabs. Samples were taken based on the absence of any reproductive complications using physical examinations. The samples were transferred to sterilised Stuart transport media and were then incubated in the Sabouraud dextrose agar with chloramphenicol at 32°C for 48 h. The identification of fungi and yeasts was confirmed by germ tube formation test, CHROM agar, urease testing and Corn meal agar medium with Tween 80.

Results

Fungal agents were isolated from 7 (25%) out of 28 male stray cats. Fungal isolates were obtained from the penis and prepuce of 4 (36%) and 7 (100%) male cats, respectively. The most commonly recovered species samples were Candida krusei (3.75%) and Penicillum spp. (6.86%) from the penis and prepuce of the cats, respectively. The external organs of male reproduction of cats were infected with 2–4 different fungal agents. Only 5 (45%) cats were infected with one fungus; however, in 6 (55%) cats, mixed fungal infections were isolated. Cats 3–4 years old had the highest fungal contamination in the prepuce region (4/7), while the penis at this age had the least contamination (1/4).

Conclusions

It is concluded that the external reproduction organs of male cats could be infected by different fungal agents.
Right‐sided colonic diverticulitis. Short and long‐term surgical outcomes and 2‐year quality of life
Authors: Lauricella Sara , Brucchi Francesco , Palmisano Dario , Baldazzi Gianandrea , Bottero Luca , Cassini Diletta , Faillace Giuseppe
Published: January 2024

Aim

We aimed to investigate the short and the long‐term outcomes and 2‐year Quality of Life (QoL) of patients with right‐sided colonic diverticulitis (RCD) surgically managed.

Method

We conducted an ambidirectional cohort study of patients with RCD undergoing surgery between 2012/2022. A colonoscopy was performed at 1‐year post surgery. The enrolled patients completed the EuroQoL (EQ‐5D‐3L) during a regular follow‐up visit at 12 and 24 months after surgery.

Results

Three hundred nineteen patients with RCD were selected: 223 (70%) patients were treated by non‐operative management (NOM) while 33 underwent surgery. Acute diverticulitis occurred in 30 patients: 9 (27.2%) were classified by CT as uncomplicated and 21 (63.6%) as complicated diverticulitis. Additionally, chronic diverticulitis occurred in 3 cases (9.2%). Specifically, 27 patients were classified by CT as 1a (81.8%) and 6 patients as 3 (18.2%). Right hemicolectomy was performed in 30 patients (90.8%), and ileo‐caecectomy in 3 (9.2%). Nine (27.27%) experienced postoperative complications: 7 (77.7%) were classified according to the Clavien‐Dindo as grade I‐II, and 2 (22.2%) as grade III. No disease recurrence or colorectal cancer (CRC) was detected on colonoscopy. Thirty (90.8%) patients completed the 24‐month follow‐up. A statistically significant difference between preoperative and 24‐month QoL index values (median 0.72; IQR = 0.57–0.8 vs. median 0.9; IQR = 0.82–1; p = 0.0003) was observed.

Conclusions

The study results demonstrate satisfactory surgical outcomes and a better QoL after surgery. No disease recurrence or CRC was observed at colonoscopy 1 year after surgery.
Carrollian conformal correlators and massless scattering amplitudes
Authors: Nguyen Kevin
Published: January 2024

Abstract

The theory of particle scattering is concerned with transition amplitudes between states that belong to unitary representations of the Poincaré group. The latter acts as the isometry group of Minkowski spacetime 𝕄, making natural the introduction of relativistic tensor fields encoding the particles of interest. Since the Poincaré group also acts as a group of conformal isometries of null infinity ℐ, massless particles can also be very naturally encoded into Carrollian conformal fields living on ℐ. In this work we classify the two- and three-point correlation functions such Carrollian conformal fields can have in any consistent quantum theory of massless particles and arbitrary dimension. We then show that bulk correlators of massless fields in 𝕄 explicitly reduce to these Carrollian conformal correlators when evaluated on ℐ, although in the case of time-ordered bulk correlators this procedure appears singular at first sight. However we show that the Carrollian correlators of the descendant fields are perfectly regular and precisely carry the information about the corresponding S-matrix elements.
The indirect effects of CMV reactivation on patients following allogeneic hematopoietic stem cell transplantation: an evidence mapping
Authors: Wu Xiaojin , Ma Xiao , Song Tiemei , Liu Jie , Sun Yi , Wu Depei
Published: January 2024

Cytomegalovirus (CMV) reactivation following allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a challenging problem, and the impact on the risk of overall mortality (OM) and non-relapse mortality (NRM) in patients following allo-HSCT is still controversial. Utilizing the evidence mapping method, we aimed to assess the effect of CMV infection on outcomes of patients post-transplantation and identify research gaps through systematic reviews (SRs) and clinical studies. PubMed, EMBASE, Web of Science, and Cochrane library databases were searched from inception until 5 July 2022 to identify relevant literature. After systematic literature screening and data extraction, evidence mapping of the effects of CMV reactivation on patients post-allo-HSCT was conducted. Three SRs and 22 clinical studies were included. In one SR, CMV reactivation was associated with an increased risk of mortality (HR 1.46; 95% CI, 1.24–1.72; P ≤ 0.001). In two SRs, CMV reactivation was associated with NRM. One SR reported CMV reactivation was potentially associated with significant protection against relapse in patients with acute myelocytic leukemia (AML), but no significant correlation with graft-versus-host disease (GVHD) was found. Lastly, in one SR CMV reactivation significantly increased the risk of invasive fungal disease (IFD). Most clinical articles reported that CMV reactivation increased the risk of renal dysfunction, poor graft function, re-hospitalization, and bacterial infections. CMV reactivation following allo-HSCT is associated with an increased risk of OM, NRM, IFD, and renal dysfunction, as well as a reduced risk of relapse in patients with AML.
Generation mechanism and temporal–spatial evolution of electron excitation induced by an ultrashort pulse laser in zirconia ceramic
Authors: Wei Chaoran , Zhang Yanming , Sugita Naohiko , Ito Yusuke
Published: January 2024

Femtosecond lasers have been applied in the machining of zirconia ($${{\textrm{ZrO}}_2}$$

ZrO
2

) ceramics because of their ultrashort pulse duration and high peak power. However, the high-precision micromachining of zirconia remains challenging owing to an unclear understanding of the ultrafast laser–material interaction mechanisms. In this study, the transient processing phenomenon induced by a femtosecond laser pulse, namely electron excitation (filament), occurring on a picosecond to nanosecond timescale, was directly observed and quantitatively investigated inside $${{\textrm{ZrO}}_2}$$

ZrO
2

. A pump-probe imaging method comprising a focusing probe beam integrated with a high-speed camera was used. The evolution process, type variation, and related interaction mechanisms of the filament were revealed under different parameters, including laser pulse energy, sample position, and pulse duration. Finally, the generation mechanism of multiple filaments was clarified and successfully elucidated. This study reveals the ultrafast laser–material interaction mechanisms and the high-precision processing in the laser drilling of zirconia ceramics.
Drivers of marine heatwaves in a stratified marginal sea
Authors: Gröger Matthias , Dutheil Cyril , Börgel Florian , Meier Markus H. E.
Published: January 2024

Marine heatwaves (MHWs) can cause devastating impacts in coastal marine ecosystems, particularly in shallow marginal seas, thereby making the understanding of the drivers of these events of paramount importance. Here, drivers for summer and winter MHWs are explored for the period 1980–2016 in the Baltic Sea, a mid-latitude marginal sea with a permanent haline water-column stratification located on the northwestern European shelf. It was found that summer MHWs are mainly forced by local meteorological conditions over the open water. They are caused by a dominant blocking over Scandinavia promoting anomalous strong shortwave downflux, calm winds, and low vertical mixing with colder sub-thermocline waters. Wintertime MHWs are linked to the advection of warm and moist air originating from the North Atlantic. These air masses lower the oceanic net heat loss at the sea surface primarily in the form of reduced latent and sensible heat losses. Vertical ocean dynamics are also affected during winter MHWs. This study finds a strengthened coastal up- and downwelling due to anomalous strong westerly winds during the time before MHWs culminate in their maximal surface extension.
Central and mixed apneas in children with obstructive sleep apnea: effect of adenotonsillectomy
Authors: Antunes Joselina , Carvalho João , Marinho Carolina , Vanderpoorten Sofie , Adónis Cristina , Freire Filipe
Published: January 2024

Purpose

Investigate the effect of adenotonsillectomy on mixed apnea index (MAI) and central apnea index (CAI) in children with moderate-to-severe obstructive sleep apnea syndrome (OSAS).

Methods

Observational retrospective analysis of polysomnographic data in children diagnosed with moderate-to-severe OSAS and without comorbidity, submitted to adenotonsillectomy.

Results

Data were available for 80 children, 55 boys and 25 girls, with a median age of 3.6 years (2.1–5.9). Before surgery AHI was 14.1 (11.0–18.4) per hour, with a median preoperative OAI of 7.1 (4.1–10.6), MAI of 1.2 (0.6–1.6) and CAI of 1.0 (0.4–2.0). Adenotonsillectomy caused significant improvements in MAI, from 1.2 (0.6–1.6) to 0.5 (0.1–0.8) (p < 0.001) and CAI from 1.0 (0.4–2.0) to 0.5 (0.1–0.9) (p < 0.001). This represents a normalization of MAI in 91.7% and CAI in 75.6% of children that had an abnormal value prior surgery.

Conclusion

Non obstructive apneas are common in children with OSAS. Adenotonsillectomy caused significant decrease not only in OAI, but also in MAI and CAI in children with moderate-to-severe OSAS.
Current challenges and practical aspects of molecular pathology for bone and soft tissue tumors
Authors: de Álava Enrique
Published: January 2024

This review shows the extraordinary change molecular pathology has induced in the classification, diagnosis, and clinical practice of molecular pathologists dealing with sarcomas. We have primarily focused on the practical aspects of molecular studies and the current and mid-term challenges for our subspecialty, ending with ten tips for the next generation of sarcoma molecular pathologists.
The success rate and complications of midline catheters in pediatric outpatient parenteral antibiotic therapy (OPAT)
Authors: Fläring Urban , Lundevall Henrik , Norberg Åke , Andersson Andreas
Published: January 2024

The use of outpatient parenteral antimicrobial therapy (OPAT) for children has several advantages, including reduced length of hospital stay and costs. A reliable vascular access is key to delivering safe and effective pediatric OPAT. In recent years, midline catheters (MC) have been increasingly used for short-term intravenous antibiotic therapy in children. However, there are no studies investigating the use of MCs in the OPAT setting. The main aim of this paper was to evaluate the success and complications of using MCs for pediatric OPAT. This was a retrospective cohort study from a tertiary academic pediatric hospital. All MCs inserted at the hospital and used for OPAT were eligible for study inclusion. The primary objective was to describe the percentage of patients able to complete OPAT without the need for additional venous access. Forty-one MCs were included in the study. Patient mean (SD) age was 5.9 (4.9) years. In 31 cases (76%, 95% CI 62–86%), the iv therapy could be successfully completed using only the MC. Imbalances between the groups suggested unfavorable outcome for saphenous vein catheters as well as for shorter and smaller-sized catheters. Fourteen patients (34%) were subjected to a MC-related complication. Pain on injection in the MC was the most frequent complication (n = 10, 24%).

   Conclusion: Midline catheters could be an alternative to central venous access for pediatric OPAT. Avoiding saphenous vein insertion and using longer and larger-sized catheters could increase MC success rate. No severe MC-related complication was found. Further randomized studies comparing different catheter types are needed.

What is Known:• For selected patients, pediatric outpatient parenteral antimicrobial therapy (OPAT) is safe and provides health-economic, psychosocial, and medical advantages compared to in-hospital care.• A reliable venous access is one of the key factors to the success of OPAT, but this can be a challenge in children.

What is New:• Using midline catheters, 76% of patients could complete their intended iv therapy without the need for additional venous access. Avoiding saphenous vein insertion and using longer and larger-sized catheters could increase the success rate.• Thirty-four percent of catheters were subject to some kind of complication, the most common being pain on injection in the catheter.
From Wire to Component: Aluminium Lithium Alloy Development for Wire and Arc Additive Manufacturing
Authors: Eimer Eloise , Ding Jialuo , Williams Stewart
Published: January 2024

The Innovative Aluminium filler Wires for Aircraft Structures (IAWAS) project aimed to demonstrate the potential of Wire Arc Additive Manufacture (WAAM) for the production of aluminium lithium components. Preliminary testing demonstrated the possibility of depositing an 2395 aluminium lithium filler wire using a plasma arc heat source and a local shielding device. The deposit had a low porosity level but also low ductility caused by long, vertical, segregated grain boundaries. Both chemical composition and deposition conditions are known to impact the deposit microstructure. In-situ alloying, an efficient technique to develop new material, was implemented using plasma arc as a heat source on aluminium lithium alloys. The results aligned with the literature review on the impact of copper on crack sensitivity and led to the design of a new alloy. Unfortunately, the composition selected yielded challenges during the drawing process, and the filler material quality was poor, leading to a low WAAM deposit quality. Machine hammer peening was implemented on the AA2395 alloy, resulting in a drastic increase in ductility and yield strength of 480 MPa after solution treatment and ageing. This alloy was used to manufacture an aluminium lithium demonstrator to showcase the potential of WAAM to produce real-life components.