bluuebunny/crossref_metadata_2025 huggingface dataset:
Poly(o-Phenylenediamine)/ Montmorillonite Nanocomposites: A Novel Strategy to Arrest Bacterial Pathogens Infestation
Authors: Verma Anurakshee , Parveen Romana , Shamsi Tooba Naz , Khan Azmat Ali , fatima sadaf , riaz ufana
Published: May 2021

Antibacterial potential of NC were investigated by the broth microdilution and agar well diffusion methods. Further, effective concentration (EC50) and minimum inhibitory concentration (MIC) of the NC were determined. Intercalation and in-situ polymerization of POPD within MMT was successfully obtained using sonochemical technique.The NC was then checked for antimicrobial activity against four bacterial strains and they showed potent antibacterial activity in both broth and on agar plate. Quantitative test in liquid media clearly showed that NC had viable cells reduction ability for testing strains. Results obtained here concluded that the NC can prevent the infestation of various bacterial pathogens effectively.
NEK7 Promotes Gastric Cancer Progression as a Cell Proliferation Regulator
Authors: Li Yike , Zhu Xiaoran , Zhan Yue , Yuan Wenzhen , Jin Wei-lin
Published: May 2021

Background: Gastric cancer is one of the most common malignant tumors of alimentary canal. However, its targeted therapy develops at a slow pace. Thus, exploring the mechanism of gastric cancer cells’ malignant behavior is of crucial importance to its therapeutic method exploitation. Mammalian NIMA-related kinases are considered to play a significant role in cell proliferation. However, NIMA family proteins have not been reported in gastric cancer yet. Methods: Bioinformatics analysis was used to clarify the expression patterns of NEK1-NEK11 and their effects on prognosis. We also analyzed the effect on immune infiltration and related pathways of NEK7. At cell level, EdU assay, cell cycle assay and CCK-8 assay were utilized to clarify the NEK7 effect on gastric cancer cell proliferation. Mice subcutaneous model revealed the regulating effect on gastric cancer cell proliferation of NEK7 in vivo. Results: Bioinformatics analysis revealed that NEK7 upregulates in gastric cancer and is related to poor prognosis. Meanwhile, NEK7 is related to T-stage, which has closely related to cell proliferation. Further analysis showed that NEK7 has correlation with multiple immune cells infiltration as well as related pathways of gastric cancer. Cell experiments indicated the promoting effect of NEK7 to cell proliferation, while lack of NEK7 could result in gastric cancer proliferation inhibition and G1/S arrest. Conclusion: NEK7 exert the regulatory effect during cell proliferation and is closely related to tumor immune infiltration
Antioxidant Status in Relation to Heavy Metals Induced Oxidative Stress in Patients With Polycystic Ovarian Syndrome (PCOS)
Authors: Abudawood Manal , Tabassum Hajera , Alanazi Atheer H. , Almusallam Fatmah , Aljaser Feda , Ali Mir Naiman , Alenzi Naif D. , Alanazi Samyah T. , Alghamdi Manal A. , Altoum Ghadah H. , Alzeer Manar A. , Alotaibi Majed O. , Alnuaim Lulu
Published: May 2021

Polycystic ovary syndrome (PCOS) is a global health concern in women of reproductive age as 1/15th women worldwide, is affected by this syndrome. PCOS is marked by hyperandrogenism, anovulation, menstrual abnormalities, and polycystic ovaries. Metals like arsenic, cadmium, lead and mercury are considered as systemic toxicants/human carcinogens and seems to have devastating effect on the human, even at minimal exposure. One of the probable etiological factor for PCOS identified is oxidative stress. In view of the probable association between oxidative stress, metal toxicity and PCOS, the present study evaluated the role of heavy metal in generation of oxidative stress among females. This prospective study included 106 women (56 women diagnosed with PCOS and 50women who were not diagnosed with PCOS as control women). There was no significant changes in the sociodemographic characteristics between the two groups except with the irregularity in menses and presence of acne. Levels of serum As, Cd, Pb, Hg increased and serum GSH and SOD levels diminished significantly in PCOS group compared to control at P<0.001. SOD was negatively correlated with As& Pb at P<0.05. Additionally, PCOS group exhibited a strong negative correlation between GSH and As (P<0.01), GSH and Pb (p<0.05) and GSH and Hg (P<0.01). Furthermore, As correlated positively with increased levels of Cd, Pb and Hg among PCOS women. A significant positive correlation was determined between Pb & Cd and Cd & Hg at P<0.001. The outcome of the study provides clear insight of the role of metal induced oxidative stress that plays avitalrole in the pathophysiology underlying PCOS and suggestive of the use of these markers as prognostic tools to circumvent the consequences of high risk exposure to these metals among females.
Benefits and challenges of e-learning over approximately a decade
Authors: Yu Zhonggen
Published: May 2021

In the recent decade, e-learning has been immensely accepted and achieved great success in education. This study, aiming to identify the e-learning pedagogy in a recent decade, adopts the narrative literature review method via a comprehensive online database elicitation with English key words “e-learning, technology assisted learning, mobile learning, distance learning, ubiquitous learning, education, teacher”, and “instructor” to retrieve the literature examining e-learning. Through reviewing the publications in the recent decade and main research themes, the study explores the role of information technology literacy in e-learning, e-learning acceptance and effectiveness, e-learning outcomes, interactions in the e-learning context, adaptation to e-learning, motivation and enjoyment, e-learning devices, barriers to e-learning, and ineffectiveness of e-learning alone. Future research directions could focus on specific e-learning situations, e-learning readiness and adaptiviy through interdisciplinary empirical studies.
Role of Cu Layer on the Enhancement of Spin-to- Charge Conversion in Py/Cu/Bi2Se3
Authors: Su Shu Hsuan , Chong Cheong-Wei , Huang Yu-Xiang , Chen Yi-Chun , Marchenkov Vyacheslav Viktorovich , Huang Jung-Chun Andrew
Published: May 2021

The enhancement of spin-to-charge conversion in Py/Cu/Bi2Se3 is achieved when increasing the Cu layer thickness up to 7nm. The conversion rate is studied using spin pumping technique. The inverse IEE length λIEE is found to increase up to ∼2.7nm when 7nm Cu layer is introduced. Interestingly, maximized λIEE is obtained when the effective spin mixing conductance (and thus Js) is decreased due to the Cu insertion. Monotonic increase of λIEE with decreasing Js suggests that IEE relaxation time τ is enhanced due to additional tunnelling barrier (Cu) that limits the interface transmission rate. The results have shown the importance of interface engineering in Py/TI magnetic heterostructure, which is the key factor for optimizing spin-to-charge conversion efficiency.
Vascular Pythiosis Caused by Pythium Aphanidermatum: The First Case Report in Asia
Authors: Thongsuk Pannaporn , Plongla Rongpong , Thammahong Arsa , Tiewsurin Jaruwan , Worasilchai Navaporn , Chindamporn Ariya , Suankratay Chusana
Published: May 2021

Background: Pythium, soil-borne plant pathogens, are in the class Oomycetes. They are not true fungi, but are related to diatom and algae. There are 2 human pathogens including P. insidiosum and P. aphanidermatum. To date, only 1 case of pythiosis caused by P. aphanidermatum has been reported. We present herein the first case of P. aphanidermatum vascular pythiosis in Asia.Case presentation: A 47-year-old Thai woman, living in North Thailand, with ß thalassemia/hemoglobin E presented with acute recurrent arterial insufficiency of both legs. Emergent embolectomy with clot removal was performed. The pathology of the clot exhibited noncaseous granulomatous inflammation with many fungal hyphal elements. PCR identified P. aphanidermatum with 100% identity. Finally diagnosis is vascular pythiosis. Unfortunately, inoperation due to extensive abdominal aorta involvement, the patient eventually expired after treatment with itraconazole, terbinafine, azithromycin, and doxycycline.Conclusions : To date, only 1 case of pythiosis caused by P. aphanidermatum has been reported. We present herein the first case of P. aphanidermatum vascular pythiosis in Asia.
SorGSD: updating and expanding the sorghum genome science database with new contents and tools
Authors: Liu Yuanming , Wang Zhonghuang , Wu Xiaoyuan , Zhu Junwei , Luo Hong , Tian Dongmei , Li Cuiping , Luo Jingchu , Zhao Wenming , Hao Huaiqing , Jing Hai-Chun
Published: May 2021

BackgroundAs the fifth major cereal crop originated from Africa, sorghum (Sorghum bicolor) has become a key C4 model organism for energy plant research. With the development of high-throughput detection technologies for various omics data, much multi-dimensional and multi-omics information has been accumulated for sorghum. Integrating this information may accelerate genetic research and improve molecular breeding for sorghum agronomic traits.ResultsWe updated the Sorghum Genome SNP Database (SorGSD) by adding new data, new features and renamed it to Sorghum Genome Science Database (SorGSD). In comparison with the original version SorGSD, which contains SNPs from 48 sorghum accessions mapped to the reference genome BTx623 (v2.1), the new version was expanded to 289 sorghum lines with both single nucleotide polymorphisms (SNPs) and small insertions/deletions (INDELs), which were aligned to the newly assembled and annotated sorghum genome BTx623 (v3.1). Moreover, phenotypic data and panicle pictures of critical accessions were provided in the new version. We implemented new tools including ID Conversion, Homologue Search and Genome Browser for analysis and updated the general information related to sorghum research, such as online sorghum resources and literature references. In addition, we deployed a new database infrastructure and redesigned a new user interface as one of the Genome Variation Map databases. The new version SorGSD is freely accessible online at https://bigd.big.ac.cn/sorgsd/.ConclusionsSorGSD is a comprehensive integration with large-scale genomic variation, phenotypic information and incorporates online data analysis tools for data mining, genome navigation and analysis. We hope that SorGSD could provide a valuable resource for sorghum researchers to find variations they are interested in and generate customized high-throughput datasets for further analysis.
Impact of the SARS-CoV-2 S-protein G476S mutation on the interaction with human ACE-2 receptor and neutralizing antibodies
Authors: Kwarteng Alexander , Asiedu Ebenezer , Sylverken Augustina Angelina , Larbi Amma , Twumasi Peter
Published: May 2021

The G476S mutation of the SARS-CoV-2 S-protein occurs in the receptor binding domain (RBD), the region that binds to the human angiotensin-converting enzyme 2 (hACE-2) receptor and also the main target for neutralizing antibodies. The 476S variant was first reported in the USA. Emerging evidence show that the 476S variant resists neutralization by antibodies such as S2E12 and CC6.29. The impact of the mutation on the interactions with hACE-2 receptor and the dynamics of the S-protein, has not been not fully explored. Here, we provide insights into the structure dynamics of the 476S variant and investigate the impact of the mutation on interactions with hACE-2 and selected neutralizing antibodies. We report that the mutation induces a destabilization effect in the RBD and an increased flexibility for most of the receptor binding residues. The mutation, however, does not affect the interactions with the hACE-2 receptor. Both Gly-476 and Ser-476, although located within the hACE-2 interacting residue hotspot, do not contribute to the stabilization of the RBD-hACE-2 complex. Our findings suggest that both H014 and P2P-2F6 antibodies neutralize the 476G and 476S S-proteins with similar efficacy.
Seminarlektüren auswählen: Reflexionen von Seminarlektüre online und offline
Authors: Mende Jana-Katharina
Published: May 2021

Mein Beitrag betrachtet einen Grundpfeiler jedes literaturwissenschaftlichen Seminars vor dem Hintergrund (nicht nur coronabedingter) Online-Lehre: Seminarlektüren. Texte zu lesen, zu diskutieren, für die weitere Seminararbeit zu verwenden, gehört zu den grundlegenden Tätigkeiten in literaturwissenschaftlichen Seminaren. Seminarlektüren umfassen dabei alle im Seminar gemeinsam gelesenen Texte: literarische Texte verschiedener Gattungen ebenso wie wissenschaftliche Textsorten als Sekundärliteratur. In der Hinsicht ist diese Reflexion nicht nur für die Arbeit in literaturwissenschaftlichen Seminaren gewinnbringend, sondern auch für sprachwissenschaftliche und didaktische Lehrveranstaltungen notwendig.
Entwicklung der digitalen Materialien "Aussprache und Sprechausdruck des Deutschen": Zur Optimierung der Ausspracheschulung im Deutschunterricht
Authors: Nakagawa Junko , Tachikawa Mutsumi
Published: May 2021

Das Ziel des Beitrags ist, die von uns entwickelten digitalen Materialien einer Ausspracheschulung für den DaF-Unterricht in japanischen Hochschulen vorzustellen. Im Mittelpunkt steht dabei die Diskussion, wie die Ausspracheschulung mit digitalen Medien im Deutschunterricht, vor allem im Online-Unterricht, aussehen soll.
Wissenschaftliches Schreiben im Dienst des Online-Unterrichts: Ein Erfahrungsbericht und methodische Vorschläge
Authors: Kulagina Pavlina
Published: May 2021

In den Kursen, die eine Seminararbeit als Prüfungsleistung erfordern, stellt sich folgende Frage für die Lehrenden besonders akut: Wie lassen sich vielfältige Schreibübungen in das Kursprogramm sinnvoll und effizient integrieren, die gleichzeitig als Werkzeuge des Denkens bei der Vermittlung der Seminarinhalte helfen und den Lernprozess insgesamt fördern? Unter den aktuellen Umständen lässt sich die Frage ergänzen: Wie kann die Umstellung auf den digitalen Fernunterricht von der Einführung prozessorientierter Schreibaufgaben profitieren? In meinem Vortrag werde ich einige methodische Vorschläge zum Umgang mit diesen Herausforderungen machen. Dabei werde ich mich auf meine Lehrerfahrungen allgemein sowie speziell auf studentische Rückmeldungen im Rahmen des von mir im SoSe 2020 an der Humboldt-Universität gehaltenen Seminars 'Bild und Körper in der religiösen Literatur des deutschen Mittelalters' im BA Studiengang Deutsche Literatur stützen.
Kinetics of dehydrogenation of riebeckite Na2Fe23+Fe32+Si8O22(OH)2: An HT-FTIR study
Authors: Ventura Giancarlo Della , Radica Francesco , Galdenzi Federico , Susta Umberto , Cinque Gianfelice , Cestelli-Guidi Mariangela , Mihailova Boriana , Marcelli Augusto
Published: May 2021

In this work, we address the kinetics of dehydrogenation occurring at high temperatures (HT) in riebeckite, a sodic amphibole with the ideal composition Na2Fe23+Fe32+Si8O22(OH)2. We performed isothermal experiments on both powders and single-crystals up to 560 °C and monitored the O-H stretching signal by Fourier transform infrared (FTIR) spectroscopy. Single-crystals show an initial increase in IR absorption intensity due to increasing vibrational amplitudes of the O-H bond stretching, not observed for powders. The OH-intensities vs. time were fitted using the formalism for first-order reactions. The calculated activation energies for H+ diffusion in riebeckite are 159 ± 15 kJ/mol for powders and 216 ± 20 kJ/mol for single crystals, respectively. The exponential factor m in the Avrami-Erofeev equation obtained for crystals ranges between 1.02 and 1.31, suggesting that, unlike powders, the dehydration process in crystals is not a purely first-order reaction. This implies that a second energy barrier must be considered, i.e., diffusion of H+ through the crystal. FTIR imaging showed that H+ diffusion occurs mainly perpendicular to the silicate double-chain. Our results confirm that the release of H+ from riebeckite occurs after the irreversible Fe2+-to-Fe3+ exchange, thus at temperatures >550 °C. To be effective, the process needs the presence of external oxygen that, by interacting with H+ at the crystal surface, triggers the release of H2O molecules. This implies that oxidizing conditions are required for the amphibole to be an efficient water source at depth.
SEMIQUANTITATIVE ANALYSIS OF PET/CT RESULTS IN PATIENTS WITH PROSTHETIC VALVE INFECTIVE ENDOCARDITIS
Authors:   A.N. Bakulev Scientific Center for Cardiovascular Surgery, Aslanidis I.P. , Pursanova D.M. ,   A.N. Bakulev Scientific Center for Cardiovascular Surgery, Mukhortova O.V. ,   A.N. Bakulev Scientific Center for Cardiovascular Surgery, Shurupova I.V. ,   A.N. Bakulev Scientific Center for Cardiovascular Surgery, Katunina T.A. ,   A.N. Bakulev Scientific Center for Cardiovascular Surgery, Alexandrova S.A. ,   A.N. Bakulev Scientific Center for Cardiovascular Surgery, Muratov R.M. ,   A.N. Bakulev Scientific Center for Cardiovascular Surgery, Popov D.A. ,   A.N. Bakulev Scientific Center for Cardiovascular Surgery
Published: May 2021

Purpose. To investigate the semi-quantitative assessment of 18F-fluorodeoxyglucose PET/CT in patients with prosthetic valve infectious endocarditis (PV IE) and without it. Material and methods. The analysis included results of 18F-FDG PET/CT examinations performed in 50 patients with PV – with surgically confirmed IE (n=30) and with malignancies used as control group (n=20). PET/CT results were assessed visually and semiquantitatively with calculation of parameters of 18F-FDG uptake intensity in the PV area – SUVmax and SUVratio. SUVratio was calculated as SUVmax in the CIED to SUVmean in the reference zone – aortic blood pool and liver parenchyma. Results. Visual analysis of PET/CT results revealed abnormal 18Ffluorodeoxyglucose uptake in all patients with IE (n=30); in the control group the uptake was normal in all cases (n=20). In semiquantitative analysis all parameters in the PV zone, SUVmax and two types of SUVratios, were higher in patients with confirmed IE, compared to patients without it (p<0.001). ROC-curve analysis for thresholds of SUVmax and two types of SUVratios for the diagnosis of PV IE by PET/CT with optimal sensitivity and specificity was determined: SUVmax = 3.35 (86% and 90%, respectively), SUVratio using aorta = 1.95 (89% and 85%), SUVratio using liver = 1.45 (82% and 85%). Conclusion. According to the obtained data, both visual analysis and semiquantitative assessment of 18F-fluorodeoxyglucose PET/CT images showed a good diagnostic performance in the detection of PV IE. The optimal parameter for the diagnosis of IE PV is the SUVratio using aorta with threshold of 1.95 (AUC=0.961).
THE CORRELATION BETWEEN RESULTS OF CT ANGIOGRAPHY OF INTRA - AND EXTRACRANIAL ARTERIES IN PATIENTS WITH АСUTE ISCHEMIC STROKE AND THE SEVERITY OF NEUROLOGICAL SYMPTOMS AT NIHSS SCORE
Authors:   M.P. Konchalovsky City Clinical Hospital, Brodetski B.M. , Brylin K.V. ,   M.P. Konchalovsky City Clinical Hospital, Vlassov V.V. ,   National Research University Higher School of Economics (Center for health policy), Gaman S.A. ,   Federal State Budgetary Institution National medical research center of cardiology of the Ministry of health of Russia, Gutsalyuk A.G. ,   A.K. Eramishantsev City Clinical Hospital, Ternovoy S.K. ,   I.M. Sechenov First Medical State University
Published: May 2021

To determine the detection of large intracranial artery thrombosis by CT angiography (CTA) in patients with acute ischemic stroke, depending on the severity of neurological symptoms at the international NIHSS score. Materials and methods. Study population are patients, hospitalized to the M.P. Konchalovsky City clinical hospital in Moscow during 2019 with ischemic stroke and underwent CTA scans of extra-and intracranial arteries: total 173 patients (94 women (54.3%), man 79 (45,7 %), average age – 70 years) with a diagnosis of acute ischemic stroke, who were in all cases, NIHSS scale was used to assess the severity of neurological symptoms. Intravenous fibrinolytic therapy (FT) or intra-arterial mechanical thrombectomy (TE) was performed in all cases. The Spearman rank correlation was used to measure the correlation. Results. In 63 of 173 patients (36%) NIHSS score was 6 points or less. Occlusions of large intracranial arteries were detected in 27.7% (n=46) of cases, of which only 61% (n=28) patients reached the stage of TE. FT was performed in 54% of cases (n=94). Of 46 cases with occlusion of large intracranial arteries only 2 patients (4%) had NIHSS score 6 or less. Of all patients, who underwent the CTA, only 2 (1.2%) had NIHSS score 6 or less. There was a significant positive correlation between NIHSS score and the detection of intracranial artery thrombosis. Spearman's rank correlation coefficient Rs is 0.55 (p<0.0001). For one patient brought to the TE stage, there were 6 CTA of extra-and intracranial arteries. Conclusion. There is a strong relationship between NIHSS score and the detection of intracranial artery thrombosis by CTA. With the low values of the NIHSS score (less than 6), the probability of detection of thrombosis is extremely small. It is advisable to prescribe CTA for patients with NIHSS score of 7 or more only.
SEVERITY DETERMINATION OF LUNG PATHOLOGICAL CHANGES CAUSED BY COVID-19 USING ULTRASOUND
Authors:   V.P. Demikhova City Clinical Hospital (City Clinical Hospital No. 68 in Moscow, Kirillova M.S. , Stepanova Yu.A. ,   A.V. Vishnevsky National Medical Research Center of Surgery, Kurochkina A.I. ,   A.V. Vishnevsky National Medical Research Center of Surgery
Published: May 2021

Purpose. To assess the possibilities of ultrasound examination of the lungs in the diagnosis of COVID-19 pathological changes. Materials and methods. 65 patients (50 women and 15 men) with suspected novel coronavirus infection (COVID-19), underwent ultrasound and MSCT of the lungs with an interval of no more than 24 hours, were included at the study. The patients were divided into two groups: the 1st group included 48 patients at the stage of the onset and progression of pneumonia, the 2nd group - 17 patients with signs of recovery - normalization of oxygen saturation on spontaneous breathing, decrease in body temperature (below 37.5 °С). Results. Changes in the lungs detected by ultrasound and MSCT were compared, and the correlation of these changes with lung function, assessed by blood saturation, the need for oxygen insufflation, non-invasive and mechanical ventilation, was studied. In patients without signs of recovery, ultrasound severity corresponded to the severity of MSCT. In patients with signs of recovery, the US-severity is less than the MSCT severity by at least 25% in most cases. When comparing patients with signs of recovery and those at the onset of the disease, significant differences in ultrasound severity were revealed (1.17 versus 2.1, respectively, p = 0.01). It is important that the differences in MSCT severity in these groups are not significant. A correlation was found between the degree of respiratory failure and ultrasound severity both in the general group of patients and in subgroups. The higher the degree of respiratory failure, the greater the US-severity, P = 0.00001. Conclusion. Ultrasound of the lungs allows one to suspect COVID-19 pneumonia, which is especially important during a pandemic. In patients at the onset and peak of pneumonia, the ultrasound severity of the disease, assessed by the area of the lesion, corresponds to the severity of MSCT. In patients with signs of recovery, ultrasound severity is significantly less than the severity of MSCT and is more strongly correlated with impaired lung function
MR-RELAXOMETRY IN DIAGNOSTICS OF RHABDOMYOLYSIS
Authors:   S.M. Kirov Military Medical Academy, Emelyantsev A.A. , Zheleznyak I.S. ,   S.M. Kirov Military Medical Academy, Bardakov S.N. ,   S.M. Kirov Military Medical Academy, Tsargush V.A. ,   S.M. Kirov Military Medical Academy, Belskikh A.N. ,   S.M. Kirov Military Medical Academy
Published: May 2021

Purpose. Assessing the possibilities of quantitative MRI in the diagnosis and monitoring of the course of rhabdomyolysis of various etiologies. Materials and methods. The results of MRI performed by 80 patients with clinical manifestations of rhabdomyolysis were analyzed. The diagnosis of rhabdomyolysis was confirmed by measuring the level of myoglobin (more than 70 μg/l) and CPK (more than 1000 IU/l) in the absence of laboratory and instrumental signs of myocardial damage. Scanning was carried out using T1, T2, STIR protocols, as well as the developed pulse sequences for calculating the relaxation times T1, T2 and T2*. Patients underwent MR examination at least 3 times during the course of the disease. Results. In 48 cases was detected a hyperintensive signal from muscle tissue on the T2 and STIR protocols. In 25 cases were identified MR signs of rhabdomyolysis, 16 of which were confirmed by laboratory methods and or biopsy of the affected muscle. One patient with a blood myoglobin level (577 ng/ml) showed no pathological changes in MR images. Thus, in the analyzed group, the sensitivity and specificity were 94% and 71%. Quantification protocols obtained relaxation times for the affected muscle tissue. The ROC analysis method determined cutoff thresholds for rhabdomyolysis: T1 greater than 1152 ms, T2 greater than 63 ms and T2* greater than 48 ms with sensitivity and specificity, respectively: 94% and 73%, 94% and 84%, 88% and 85%. Dynamic changes in the relaxation time during the recovery of patients had correlation relationships of high and medium strength with the main laboratory markers of rhabdomyolysis. The highest values of the correlation coefficient were found between T2 and the activity of CPK, ALS, and AST (rs = 0.805, 0.813, and 0.803; p <0.05). Conclusion. An improved technique for muscle MRI with a quantitative assessment of T2 relaxation time has high sensitivity and specificity (94% and 82%) in the diagnosis of rhabdomyolysis. Recovery of
CT FINDINGS OF AN ENDO-ORBITAL OSTEOMA PRODUCING PROPTOSIS AND THE OPTIC NERVE’S COMPRESSION
Authors:   Departamento de Imagenologia, Salud Digna, Corona-Cedillo Roberto , Saavedra-Navarrete Melanie-Tessa ,   Facultad de Ciencias de la Salud, Universidad Anahuac Mexico, Albrandt-Salmeron Arturo ,   Departamento de Imagenologia, Salud Digna, Roldan-Valadez Ernesto ,   I.M. Sechenov First Moscow State Medical University
Published: May 2021

Osteoma is a benign bone tumour, with an incidence of 2% of all orbital tumours. Osteomas located in orbit remain asymptomatic until they reach a size that originates mass effect signs such as exophthalmos, diplopia, and unilateral blindness. Materials and methods. In this case, a male patient presented to the emergency room with progressive proptosis, worsening headaches, and swelling of the left anterior periorbital and frontal sinus region one year after the beginning of the symptoms. Results. Imaging studies revealed a hyperdense mass in the left orbital floor displacing the left globe superiorly and anteriorly with the optic nerve’s compression. Conclusion. Osteoma may represent an emergency in the long term when left untreated; it may destruct the eye due to direct pressure on the optic nerve and disturbance of the ocular blood supply.
MULTIPLE INTRACRANIAL ANEURYSMS IN A PATIENT WITH NON-TRAUMATIC SUBARACHNOID HEMORRHAGE
Authors:   Research Institute – Ochapovsky Regional Hospital no. 1, Zyablova E.I.
Published: May 2021

We reported a case of multiple intracranial aneurysms concurrent with nontraumatic subarachnoid hemorrhage in a 46-year-old male patient. Unenhanced head computed tomography and computed tomography angiography of brachiocephalic vessels performed in hospital demonstrated multiple intracranial aneurysms, one of which was the source of bleeding. The diagnosis was confirmed by cerebral angiography and intraoperatively. The timely diagnosis made it possible to determine the tactics of the patient treatment in the acute period and to reduce the time of his examination
PERINEAL LOCALIZATION OF RHABDOMYOSARCOMA IN CHILDREN
Authors:   Università degli Studi di Milano, Avola E. , Lastella G. ,   Università degli Studi di Milano, Esposito A. ,   Foundation IRCCS Ca’ Granda Maggiore Policlinico Hospital
Published: May 2021

Rhabdomyosarcoma is one of the most common tumors in the pediatric age, but perineal localization is very rare, with a poor prognosis due to late diagnosis. Magnetic resonance (MR) is a non-invasive technique that is very useful in the evaluation of local infiltration and can facilitate the diagnosis. In this article, we present a case of perineal rhabdomyosarcoma diagnosed with pelvic MR, with simultaneous presence of multiple synchronous metastases.
POST-MORTAL COMPUTER TOMOGRAPHY IS AN IMPORTANT ADDITIONAL METHOD DIAGNOSIS IN THE CASE OF CRIMINAL DEATH OF A CHILD
Authors:   Moscow Regional Research Clinical Institute, Dubrova S.E. , Chumakova Yu.V. ,   he Department of Forensic Medicine of Moscow Regional Research Clinical Institute, Kislov M.A. ,   I.M. Sechenov First Moscow State Medical University, Klevno V.A. ,   Moscow Regional Research Clinical Institute, Zolotenkova G.V. ,   I.M. Sechenov First Moscow State Medical University, Serova N.S. ,   I.M. Sechenov First Moscow State Medical University
Published: May 2021

Mechanical asphyxia is one of the leading causes of violent death, which determines the improvement of the evidence base for this type of death. At forensic examination, the morphological picture of asphyxia doesn’t differ from sudden death, as well as with other types and mechanisms sudden (acute) death, which makes it difficult to determine the immediate cause of death. The article discusses to use case of computed tomography (CT) for visualize formation, which found on the corpse (injury of bones, stab wounds, determination of the level of location of a foreign object in the oropharynx child) with the establishment of the immediate cause of death. Posthumous CT examination made it possible to assess the state of "hard to reach" for the classic study of corpse zones, confirm the direct cause of death, identify the presence of gas in the abdominal cavity and small pelvis that can’t be established during sectional examination of a corpse
EVALUATION OF DOSE DELIVERY FOR TOTAL MARROW IRRADIATION USING IMAGING DATA OBTAINED WITH TOMOTHERAPY DEVICE
Authors:   Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Loginova A.A. , Tovmasian D.A. ,   M.V. Lomonosov Moscow State University, Chernyaev A.P. ,   M.V. Lomonosov Moscow State University, Kobyseva D.A. ,   Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Lisovskaya A.O. ,   Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Nechesnyuk A.V. ,   Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
Published: May 2021

Fractionated total marrow irradiation and lymphoid irradiation (TMLI) is a highly conformal method of radiotherapy, requiring a high degree of dose delivery accuracy. This study presents a quantitative assessment of the delivered dose while taking into account the influence of daily positioning using one patient receiving TMLI as an example. Material and methods. Before each treatment session on TomoTherapy preliminary visualization is performed by megavoltage computer tomography (MVCT). The resulting images are used to correct the position of the patient and thereby to minimize the error of dose adjustment. In this study dose was recalculated for each treatment fraction, taking into account the current radiation geometry based on the MVCT images of the patient. The planned and delivered total dose distributions were compared. Results. The difference between the delivered and planned average dose in target comprising bone marrow and lymphoid tissue was less than 0.5%. The volume of the lungs, receiving a dose of 8 Gy did not exceed 39.3% of the total delivered dose, at the same time the coverage of the targets met prescribed requirements. Discussion. Appropriate immobilization, visualization with subsequent correction of the patient's position prior to each fraction allowed for reliable and accurate dose delivery. The evaluation of the delivered dose provides opportunity for an objective analysis of the therapy. Conclusion. The analysis of the delivered dose distribution based on MVCT visualization of the patient's body demonstrated the safety of TMLI method in terms of dose to the organs at risk, as well as the acceptable quality of the target coverage
X-RAY MANIFESTATIONS OF OSTEOMYELITIS JAWS
Authors:   National Medical Research Center Central Research Institute of Dentistry and Oral Surgery, Arzhantsev A.P.
Published: May 2021

Among purulent-necrotic processes in the jaws, odontogenic osteomyelitis occurs in most cases in comparison with posttraumatic and hematogenic osteomyelitis. A separate group of jaw lesions consists of radiation, bisphosphonate and phosphoric necrosis, which at the stage of joining the inflammation have x-ray manifestations of the osteomyelitic process. X-ray semiotics of osteomyelitis of the jaws is diverse. X-ray features of osteomyelitis depend on the etiology, stage of course and form of the bone inflammatory process. X-ray diagnosis of osteomyelitis should be carried out taking into account the history of the disease and identifying factors that contribute to their development. Since orthopantomography does not provide comprehensive information about the state of the dental system, this technique can be considered as a method of primary detection of osteomyelitis of the jaws. At the next stage of diagnosis, it is advisable to use a CT scan, especially for lesions of the upper jaw with spread to other facial bones.
RADIOLOGY IN DENTAL IMPLANTATION
Authors:   I.M. Sechenov First Moscow State Medical University, Serova N.S. , Sokkar A. ,   I.M. Sechenov First Moscow State Medical University, Pavlova O.Yu. ,   I.M. Sechenov First Moscow State Medical University, Medhat A. ,   I.M. Sechenov First Moscow State Medical University
Published: May 2021

The detailed review on dental implantation is presented including preoperative planning, intraoperative control and postoperative follow-up. Since successful outcome depends on the precise preparation for the surgical intervention, the range of radiological methods is described in the review as well as new methods and techniques of dental implantation. Advantages and limitations of different methods are presented with the summary of possible complications and their radiological appearance
MRI AND CARDIAC PACEMAKERS: CURRENT STATUS
Authors:   I.M. Sechenov First Moscow State Medical University, Vasyukov S.S. , Kuzmenkov D.V. ,   I.M. Sechenov First Moscow State Medical University, Ustyuzhanin D.V. ,   National Medical Research Center of Cardiology, Shariya M.A. ,   I.M. Sechenov First Moscow State Medical University
Published: May 2021

Purpose. Until recently, an implanted pacemaker was an absolute contraindication to MRI, regardless of the field of study. Patients with pacemakers couldn’t undergo MRI and get the diagnostic information. In recent years, new types of implantable devices that are compatible with MRI have been developed and introduced into clinical practice. This allowed MRI examinations for such patients, including cardiac studies. The review focused on the safety of MRI in patients with implanted MR-compatible pacemakers. The features of procedure, differences from the routine study are considered. The images quality and interpretability both in the implantation zone and in the area of the electrodes are discussed
DELAYED CT SCAN OF THE LUNGS IN PATIENTS WITH COVID-19 PNEUMONIA
Authors:   National medical research center of cardiology, Gaman S.A. , Ternovoy S.K. ,   I.M. Sechenov First Medical State University, Pogosova N.V. ,   National medical research center of cardiology, Veselova T.N. ,   National medical research center of cardiology, Belkind M.A. ,   Belkind
Published: May 2021

Purpose. Assessment the state of the lungs using CT in the dynamic follow-up of patients who have suffered from viral COVID-19 pneumonia in the delayed period after 6-10 months, and to identify the relationship of residual lung changes with the clinical condition and results of external respiratory function (ERF). Materials and methods. We examined 78 patients who had suffered from bilateral polysegmental viral COVID-19 pneumonia in April-May 2020, using multi-spiral computed tomography (CT) of the lungs. All patients had a medical history, performed CT scans of the lungs in the acute and delayed (6-10 months after hospitalization) phases, and a study of FVD in the delayed phase. The analysis of a series of tomograms of the lungs in dynamics was carried out. We developed an severity score of the lung condition (LungSS), expressed in the total score, which was calculated based on the score of typical patterns characteristic of viral Covid19-pneumonia, as well as residual changes and areas of fibrosis. LungSS was calculated for each patient in the acute and delayed follow-up periods. Results. The present study shows the dynamics of lung changes in the delayed period 6-10 months after the viral Covid19-pneumonia. Residual lung changes were detected in 66 people (84,6%). Of these, 35,9% of patients have areas of fibrosis, but most of the residual changes are linear and small-nodular seals (76,9%). The frequency of detection of residual reticular changes and consolidation was low (15,3%, 1,3%, respectively). Attention is drawn to the relatively frequent detection of areas of "Ground-glass opacity "(10,8%). In patients with severe and critical course of viral Covid19-pneumonia (CT3 and CT4), LungSS in the delayed follow-up period did not significantly differ from that in patients with mild and moderate course (CT1 and CT2) of the disease (4,5 [0,22], 2,5 [0,16], accordingly, p=0,61). There was no significant correlation between the detected residual lung changes in the delayed period and ERF. Conclusion. In a significant part of patients (84,6%) who have suffered from COVID19 viral pneumonia, residual changes in the lung parenchyma persist, mainly in the form of linear seals and to a lesser extent fibrosis. These changes did not have a reliable relationship with the results of the FVD. LungSS proposed in this study reflects the dynamic picture of lung changes in the acute and delayed period, and can be a good indicator for monitoring patients who have suffered from COVID-19 viral pneumonia.
Síndrome de Hamman: una causa rara de dolor torácico en niños
Authors: Pérez Muñoz Andrés Felipe , Salas Mesias Andrea , Pérez Muñoz William Fernando
Published: May 2021

Introducción: el dolor torácico es una causa frecuente de consulta al servicio de urgencias pediátricas. Una causa poco conocida es el neumomediastino, el cual puede clasificarse en secundario, cuando hay un desencadenante y en espontáneo, cuando no hay causa evidente. También es llamado síndrome de Hamman, el cual tiene una incidencia que oscila entre uno en 30 000 a 44 000 consultas a urgencias y se presenta predominantemente en hombres. Reporte: Presentamos el caso de una niña de 12 años, previamente sana, quien consultó por un cuadro de 12 horas de evolución de dolor torácico de características pleuríticas, de inicio súbito, asociado a disnea y diaforesis, sin historia de trauma, síntomas respiratorios, gastrointestinales u otra sintomatología previa. Y a quien posteriormente se le hizo diagnóstico de neumomediastino espontáneo.
Discusión: esta enfermedad es muy poco frecuente en niños. La mayoría de los casos se autolimitan rápidamente con manejo sintomático y muy pocos pueden complicarse con taponamiento cardiaco. La radiografía de tórax es el método diagnóstico más preciso.  .
Petrographic and petrogeochemical features of harzburgites and dunites of the Agardag and Ulor massifs (South-Eastern Tyva)
Authors:   National Research Tomsk State University, Peshkov Alexey A. , Chernyshov Alexey I. ,   National Research Tomsk State University
Published: May 2021

The objects of study are the Agardag and Ulor ultramafic massifs, which are part of the South Tuva ophiolite belt. The aim of this work is to study the petrographic, petrochemical and geochemical features of harzburgites and dunites of the studied massifs. As a result of petrographic study, the main types of rocks that make up the studied massifs were identified. Harzburgites predominate in the Agardag massif, while dunites are more common in the Ulor massif. In the Ulor massif, dunites and harzburgites are often plastically deformed by syntectonic recrystallization with the formation of porphyroclastic structures. The chemical compositions of olivine and Cr-spinels in harzburgites and dunites in both massifs are similar. The composition of olivine corresponds to forsterite, while the ultramafic rocks of the Ulor massif show large variations in Fa and a tendency towards a decrease in NiO. Chromium spinels in ultramafic rocks of the Ulor massif have wider compositional variations and are represented by chromites, alumochromite and subferrial alumochromite; they are completely free of V2O5. According to the composition of Cr-spinels, the degree of melting of ultramafic rocks was determined, which turned out to be similar for both massifs, ~40–50%. A higher chromium content of the ultramafic rocks of the Agardag massif is noted, which is probably responsible for its increased potential chromite content. Ultramafic rocks of the Agardag and Ulor massifs are intensely depleted formations that arose in similar conditions, which determines the closeness of their rock and material compositions. The revealed differences are due to variations in the degree of depletion and the conditions of their consolidation in the earth's crust, determined by the structural position, as well as metamorphism of the enclosing frame and the introduction of later intrusions.
Geochemical characteristics of magnesiocarbonatites from Muostalaah apatite occurrence and Birikeen apatite deposit (Aldan-Stanovoy shield, South Yakutia, Russia)
Authors:   Sobolev Institute of Geology and Mineralogy, Siberian Branch of the Russian Academy of Sciences, Ponomarev Jean D. ,   Novosibirsk State University, Doroshkevich Anna G. ,   Sobolev Institute of Geology and Mineralogy, Siberian Branch of the Russian Academy of Sciences,   Tomsk State University,   Geological Institute, Siberian Branch of the Russian Academy of Sciences, Prokopyev Ilya R. ,   Sobolev Institute of Geology and Mineralogy, Siberian Branch of the Russian Academy of Sciences,   Novosibirsk State University, Chebotarev Dmitry A. ,   Sobolev Institute of Geology and Mineralogy, Siberian Branch of the Russian Academy of Sciences
Published: May 2021

Apatite-bearing ore occurrence Muostalaah and phosphate deposit Birikeen are magnesiocarbonatite complexes of the Seligdar type, located within the Nimnyrskaya submeridional metallogenic domain in the Aldan-Stanovoy shield in South Yakutia, Russia. This study presents geochemical characteristics of carbonatites and adjacent apatite-bearing silicate rocks of the Birikeen apatite deposit and Muostalaah apatite occurrence. Comparison of these complexes with the Seligdar deposit and other magnesiocarbonatite complexes of the world was made. Based on the chemical analysis of the petrogenic components of the Muostalaah and Biriken carbonatites, it was concluded that these rocks belong to magnesiocarbonatites, similar to the magnesiocarbonatites of the Seligdar deposit. The chondrite-normalized REE spectra of magnesiocarbonatites and apatite rocks are characterized by LREE enrichment relative to HREE with average La/Yb(cn) ratios of 45 and 100 for the Muostalaah and Birikeen rocks, respectively. Most of the REE patterns are within the field of the world magnesiocarbonatites. The trace-elements abundances of carbonatites and apatite rocks record negative Nb, Pb, Sr, Zr, Hf and Ti anomalies and Th, U and REE enrichment. Сoncentrations of Th, U, Zr, and Hf are characterized by a wide spread of values. The trace-element patterns of the Birikeen and Muostalaah carbonatites are generally similar to the patterns of the world magnesiocarbonatites, including Seligdar rocks. Based on the results of isotopic studies of the Sm/Nd and Rb/Sr systems, it was concluded that the primary melts for the Muostalah and Birikeen carbonatites were formed from a long-lived enriched mantle source that separated from the depleted mantle in the Late Archean.
Late Quaternary displacements along the Zunduk fault according to ground-penetrating radar and morphostructural analysis (northwestern coast of Lake Baikal)
Authors:   Institute of the Earth's Crust of the Siberian Branch of the Russian Academy of Sciences, Denisenko Ivan A. , Lunina Oksana V. ,   Institute of the Earth's Crust of the Siberian Branch of the Russian Academy of Sciences
Published: May 2021

The article considers the results of GPR studies of the Zunduksky fault section activated between the Cape Oto-Khushun and the Zunduk River, activated in the late Quaternary. The aim of this work is to clarify the kinematic type, determine the vertical displacement amplitudes, and dip angles of the Zunduksky active fault activated in the late Quaternary, as well as determine the maximum magnitude of the earthquake that could occur as a result of the activation of the fault. The work was carried out by OKO-2 GPR with a shielded antenna AB-90 and ABDL-Triton. In addition to the main method, morphostructural analysis of the ledge was used. As a result of the work performed, it was found that the Zunduksky fault in the Late Quaternary was activated under tectonic extension with predominant fault displacement kinematics. The one-act vertical displacements along the seismic fracture change from SW to NE from 6.9 to 1.6 m. When the Late Quaternary ledge of the Zunduksky fault formed, the plastic component of the displacement had a certain value, the contribution of which is from 18 to 78 % of the total displacement. Paleo-earthquake magnitudes calculated from the maximum vertical displacement are Mw = 7.3 and Ms = 7.5.
The Variation of the stress-and-strain state of the Vuoksi Fault Zone area (Vyborg district)
Authors:   Schmidt Institute of Physics of the Earth of the Russian Academy of Sciences, Marinin Anton V. , Sim Lidiya A. ,   Schmidt Institute of Physics of the Earth of the Russian Academy of Sciences, Bondar Ivan V. ,   Schmidt Institute of Physics of the Earth of the Russian Academy of Sciences
Published: May 2021

The stress-and-strain state of the rock massif and the kinematic type of faults of the Vuoksi fault zone (Karelian Isthmus) for the latest stage of tectonic history were determined by field tectonophysical methods. The main information was obtained from geological stress/strain indicators, which were mostly represented by measurements of minor faults and slickensides with kinematic information (the direction of relative displacement) on the fault plane. Near the Vuoksi fault zone, systems of faults with an orientation close to the strike of this regional fault structure are observed. Most widespread are strike-slip faults, whereas faults with normal or reverse displacement make up less than a quarter of the total number of faults. The STRESSgeol software based on the method of cataclastic analysis was used to restore stress-and-strain state. The variable orientation of the principal stress axes was determined in the studied area. The two main directions of maximum compression are NE-SW (to ENE-WSW) and NW-SE (to WNW-ESE). The axes of the maximum deviatory extension are subhorizontal and are directed in the NNE-SSW and NW (to WNW-ESE) direction. The intermediate axis often occupies a sub-vertical position. The horizontal shear stress state type prevails for the entire zone, and lateral shear displacements are also characteristic of this fault zone. This stress state type of the studied part of the Baltic Shield is significantly different from the stress state type of orogenic belts, where, along with horizontal shear stress state type, the situation of horizontal compression stress state type dominates. The obtained variability of the directions of maximum compression in the studied area can be preliminarily correlated with the previously identified zone of “unstable tectonic stresses” of the East European Platform.