bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical Model of CAR T-Cell Therapy for a B-Cell Lymphoma Lymph Node
Authors: Sabir Soukaina , León-Triana Odelaisy , Serrano Sergio , Barrio Roberto , Pérez-García Victor M.
Published: February 2025

CAR T-cell therapies have demonstrated significant success in treating B-cell leukemia in children and young adults. However, their effectiveness in treating B-cell lymphomas has been limited in comparison to leukemia. In this paper we present a mathematical model that elucidates the dynamics of diffuse large B-cell lymphoma and CAR T-cells in a lymph node. The mathematical model aids in understanding the complex interplay between the cell populations involved and proposes ways to identify potential underlying dynamical causes of treatment failure. We also study the phenomenon of immunosuppression induced by tumor cells and theoretically demonstrate its impact on cell dynamics. Through the examination of various response scenarios, we underscore the significance of product characteristics in treatment outcomes.
In Silico Discovery of Antigenic-Secreted Proteins to Diagnostic Human Toxocariasis
Authors: Henao María A. , Cortes Isabella , Isaza Juan P.
Published: February 2025

Background

Human toxocariasis is a helminthic zoonosis caused by infection of Toxocara canis or T. cati. Humans can be infected by through ingestion of embryonated eggs from contaminated water, food or soil. Diagnosis is challenging, immunodiagnosis tests are commonly implemented with major pitfalls in the cross-reactivity with other pathogens, particularly in endemic areas.

Methods

With the aim of identify species-specific genes encoding for highly expressed antigenic proteins, a list of parasites that may infect humans and that might present similar clinical symptoms to T. canis infections was built. Only organisms whose genomes were completely sequenced and the proteome predicted were included. First, orthologous proteins were detected and the subcellular localization of T. canis proteins was predicted. In order to identify differentially expressed genes encoding proteins in larvae L3, pair-wise comparisons among transcriptomes from body parts and genders were performed. Finally, all secreted proteins classified as species-specific of T. canis, whose genes were upregulated in larvae L3 were included in an antigenic prediction.

Results

Twenty-eight parasites were included in the analyses, proteins of T. canis were clustered in 11,399 groups, however, 279 were species-specific groups which represent 816 proteins. Three hundred and twenty-two proteins were predicted to be secreted and upregulated in larvae L3, however, after filtering these proteins by their orthology inference, only three proteins met all the features included in this study (species-specific, upregulated, secreted, and antigenic potential). To conclude, our strategy in the study is a rational approach for discovering antigenic proteins to be used in diagnosis.
Development of a 3D-knee brace joint using MRI data and a genetic algorithm
Authors: Schmid Quirin T. , Ruschke Stefan , Karampinos Dimitrios C. , Senner Veit
Published: February 2025

Approximately 40% of sports-related injuries affect the knee joint, with the anterior cruciate ligament particularly susceptible to injury. The use of knee orthoses for the prevention of knee injuries has become a common practice in sports such as ice hockey, American football, and alpine skiing. However, orthoses cannot accurately reproduce the complex kinematics of the knee. This might be associated with a decrease in performance and comfort. This study aims to improve the congruence between orthotic joints and a measured knee motion. Knee kinematics of four male participants were recorded using a combination of video motion capture and MRI. Finite helical axes were computed to design the new orthotic joint. The new joint consists of two four-bar linkages optimized by a genetic algorithm to approximate the finite helical axis positions. A multi-body simulation was used to determine the change of constraining forces in the knee using the new orthosis compared to a conventional one. The mean squared error between knee and orthosis motions for the medial joint parts was 0.07 to 2.04 mm and 1.1 to 10.65 mm for the lateral joints. The total MSE was 3.46 mm. The simulation results showed substantially reduced constraining forces for the new joint, indicating a better match with natural knee kinematics. This improvement could increases orthosis effectiveness and comfort, thereby accelerating the healing process. In conclusion, the introduced approach allows a more accurate replication of the knee’s natural movement, thereby minimizing constraining forces in the knee and possibly improving comfort.
Reconfiguring International Security – The Strategic Evolution of Modern Warfare
Authors: Schäfer Philip Jan
Published: February 2025

This paper delves into the evolving nature of international security, focusing on the strategic transformations within military thought and practice that are increasingly shaping global power dynamics. Moving beyond the traditional emphasis on high-level political decisions, it is argued that the day-to-day practices of military institutions, especially their adaptations to modern warfare, play a crucial role in defining a state’s international stance. This is shown by analyzing the development of new conceptual frameworks within NATO and the PLA.
How instructors use learning analytics: the pivotal role of pedagogy
Authors: Li Qiujie , Jung Yeonji , Wise Alyssa Friend
Published: February 2025

This study fills a gap in knowledge regarding experienced instructors’ use of learning analytics, focusing on differences in their approach, the knowledge and skills they activate, and the development of these knowledge and skills. Through a qualitative analysis of think-aloud interviews with 13 analytics-experienced instructors, two distinct profiles of analytics use emerged. Instructors in the first profile prioritized monitoring student engagement and performance to foster desirable behaviors, using analytics to align students with course expectations. Instructors in the second profile focused on understanding student perceptions of learning, aligning the course design with diverse learning behaviors and needs. To arrive at such use, instructors went beyond mere acquisition of technical knowledge to also integrate pedagogical knowledge into their analytics practices. Lastly, the study uncovered specific learning analytics supports, such as ongoing individual consultations, invaluable for developing the needed technical and pedagogical knowledge. Together, the results of this study reveal the pivotal role of pedagogy in analytics use, calling for refinement of conceptual models and tailoring of practical support for instructors.
Mindfulness-Based Intervention to Reduce Sensitivity to Anxiety in a Spanish Primary Education Setting
Authors: García-Lorenzo Rut , Carbonero-Martín Miguel Ángel , Valdivieso-León Lorena , Izar-de-la-Fuente Iker
Published: February 2025

Objectives

Mindfulness involves the ability to pay full and conscious attention to what is happening in the present moment. Scientific evidence supports its benefits in the educational field, contributing to the development of strategies that help students cope academically, socially and emotionally. Meta-analyses on mindfulness in the Spanish educational context reported significant improvements along the same lines. The aim of this study was to determine whether a mindfulness-based intervention for primary school students improved their sensitivity to anxiety.

Method

A total of 352 students (170 boys, 182 girls) aged 6 to 12 years participated in Spain. A quasi-experimental pre-test-post-test design was used, with experimental group (266 students) and control group (86 students). Anxiety sensitivity was measured with the Anxiety Sensitivity Index for Children. The intervention followed a sequential learning order based on the Mindfulness-Based Stress Reduction (MBSR) programme.

Results

A significant decrease in anxiety sensitivity was observed in the post-intervention measure. Additionally, comparisons of pre-test and posttest scores in the control group revealed significant differences. In terms of effect size, the difference between pre- and post-intervention scores was close to medium (Cohen's d = 0.43).

Conclusions

The efficacy of the programme was confirmed, and it was shown that the mindfulness intervention was beneficial; in the experimental group, anxiety sensitivity decreased significantly compared to that in the control group after participation in the programme.
Learning-based pattern-data-driven forecast approach for predicting future well responses
Authors: Kim Yeongju , Min Baehyun , Sun Alexander , Ren Bo , Jeong Hoonyoung
Published: February 2025

Forecasting well responses, such as flow rates and pressures, is crucial for effective reservoir management and investment decision-making in the development of subsurface reservoir resources. Recently, data-driven forecast methods, such as data-space inversion (DSI) and a learning-based data-driven forecast approach (LDFA), have been introduced to mitigate the computational cost and geological constraint issues of history-matching methods. However, DSI and LDFA have extrapolation, conditioning, and prediction variance issues. In this study, we propose two simpler alternatives, a learning-based pattern-data-driven forecast approach (LPFA) and an ensemble conditioning step (ECS), to resolve the issues associated with DSI and LDFA. LPFA mitigates the extrapolation issue by scaling well responses for each instance using the mean and variance of an observation period. ECS addresses the conditioning and prediction variance issues of LDFA and LPFA by combining predictions of multiple learning models and screening out predictions that do not sufficiently honor observed data. The prediction performances of DSI, LDFA, LPFA, and ECS were compared using two benchmark models: Brugge and Olympus models. Among these methods, LPFA provided the most accurate predictions for future well responses and reasonable uncertainty intervals, achieving an error of 2.3%. Even when predicting well responses outside the range of prior data, LPFA maintained a prediction error of 4.8%, unlike the other methods whose performance significantly declined. ECS improved the prediction accuracy by 1–2% and reduced the uncertainty in the predictions of future well responses by approximately 50%. Our approaches are generic and can be integrated with other data-driven forecast methods to enhance prediction performance.
Exploring the therapeutic potential of oleanolic acid and its derivatives in cancer treatment: a comprehensive review
Authors: D’Mello Rachel Savio , Mendon Vividh , Pai Padmini , Das Ipshita , Sundara Babitha Kampa
Published: February 2025

Oleanolic acid (OA) is a triterpenoid that occurs naturally and may be isolated from various plants. Analogs of oleanolic acid can be produced artificially or naturally. The current treatments have limited selectivity and may also impact normal cells. OA and its derivatives provide a promising cancer treatment platform with greater selectivity and less toxic effects. As a result of their enhanced sensitivity, selectivity, and low toxicity, they are great options for focusing on particular biological pathways and reducing the growth of tumor cells. The effects of OA and derivatives of OA on various cancer types have been investigated. However, breast and hepatocellular malignancies are the most studied cancers. In breast cancer, derivatives such as saikosaponin A (SSa), saikosaponin B (SSb), and SZC014 influence key pathways such as the Janus kinase/signal transducer and activator of transcription (JAK/STAT), protein kinase-B (Akt), and nuclear factor-kappa B (NF-κB) pathways, inhibiting metastasis, angiogenesis, and cell migration, respectively. When a para-aminobenzoic acid (PABA)/nitric oxide (NO) derivative of OA is administered to HepG2 cells, the reactive oxygen species (ROS)/mitogen-activated protein kinase (MAPK)-mediated mitochondrial pathway causes apoptosis. Nanoformulations incorporating OA, such as OA-paclitaxel (PTX), show potential for suppressing tumor progression by inhibiting drug efflux mechanisms. Thus, exploring the interactions of OA and a few of its derivatives with various cellular pathways offers a promising approach to combating different types of cancer. This review delves into the potential of oleanolic acid and its derivatives in retarding cancer progression through their interactions with diverse cellular pathways.
Evaluation of systemic inflammatory response following transcatheter aortic valve replacement: a pathway to rational antibiotic use
Authors: Guthoff Henning , Lohner Valerie , Mons Ute , Götz Julia , Wienemann Hendrik , Wrobel Jan , Nienaber Stephan , Macherey-Meyer Sascha , von Stein Philipp , Baldus Stephan , Adam Matti , Körber Maria Isabel , Jung Norma , Mauri Victor
Published: February 2025

Purpose

Elevations in inflammatory markers after transcatheter aortic valve replacement (TAVR) often lead to preemptive antibiotic therapy (ABT). Distinguishing between physiological inflammatory reaction and true infection is crucial for rational ABT use.

Methods

This retrospective study included 1275 consecutive TAVR patients from January 2020 to July 2022. Infectious foci, ABT administration, and inflammatory markers over seven days post-procedure were evaluated. Using multivariable logistic regression, predictors for infection were identified and integrated into the Risk of Infection After TAVR (RIAT) score.

Results

An infectious focus was retrospectively identified in 2.6% of patients, while 11.4% received ABT. Distinct trends in body temperature (BT), white blood cells (WBC), and C-reactive protein (CRP) were noted, with BT and WBC peaking on day 1 and CRP on day 3. Significant predictors of infection included a rise in BT of ≥ 0.2 °C between day 1 and 3 (odds ratio [OR] 3.08, 95% confidence interval [CI] 1.38–6.88, p = 0.006), elevated WBC counts ≥ 12 × 109/L (OR 3.77, 95% CI 1.67–8.48, p = 0.001), and CRP levels ≥ 80 mg/L (OR 5.72, 95% CI 2.59–12.64, p < 0.001) within three days after TAVR. Integrating these into the RIAT score revealed an infection probability of 1.5% for scores 0–3 points, 9.2% for scores 4–6 points, and 54.5% for scores 7–8 points.

Conclusion

Our findings indicate significant ABT overuse among TAVR recipients, likely due to misinterpretation of postoperative physiological reactions. Incorporating specific changes and thresholds of BT, WBC, and CRP post-TAVR into the RIAT score improved risk prediction for infection, underscoring its utility in enhancing antibiotic stewardship in this growing patient population.
A Team Approach: How the LEND Program Can Provide Interdisciplinary Training for Behavior Analysts
Authors: Vincent Lori B. , Scott Meagan , Weber Stephanie , Srivorakiat Laura , Stepanek Mary , Smith Jennifer
Published: February 2025

Supporting people with neurodevelopmental disabilities often requires interdisciplinary collaboration and effective partnerships with clients and their families. Behavior analysts receive intensive training and supervision in a variety of domains; however, expanding interdisciplinary training for behavior analysts is needed. Interdisciplinary training programs, such as the Leadership Education in Neurodevelopmental and Related Disabilities (LEND) programs, offer trainees the opportunity to hone their skills as advocates for people with neurodevelopmental disabilities and collaborators as part of an interdisciplinary team. Historically, many LEND programs have not offered training positions specifically to behavior analysis students or professionals, although some behavior analysts have participated as trainees in other disciplines such as psychology or special education. The benefits, barriers, and possible future directions of interdisciplinary training for behavior analysts within a LEND program are discussed through the experience of the University of Cincinnati LEND Program which added an Applied Behavior Analysis (ABA) training track in 2020.
Vehicle-to-Everything Communication in Intelligent Connected Vehicles: A Survey and Taxonomy
Authors: Zhang Xinyu , Li Junxian , Zhou Jingyi , Zhang Shiyan , Wang Jingyuan , Yuan Yi , Liu Jiale , Li Jun
Published: February 2025

This paper conducts a thorough exploration of vehicle-to-everything (V2X) communication in the realm of intelligent connected vehicles (ICVs). It initiates by tackling challenges across three pivotal phases of cooperative communication: pre-communication, during-communication, and post-communication. The discourse delves into a spectrum of concepts and strategies to surmount these challenges. Furthermore, it meticulously scrutinizes diverse communication scenarios and associated techniques, evaluating their significance and feasibility. Moreover, an in-depth analysis of various datasets is undertaken, considering their distinctive attributes and suitability for diverse communication tasks. The paper critically examines and debates the platforms and frameworks used in the experiments, providing valuable insights into their performance. Following a comprehensive review of existing methods and datasets, the paper identifies potential research directions and challenges that warrant further exploration in the realm of V2X communication for intelligent connected vehicles. This comprehensive examination contributes to a deeper understanding of the subject, paving the way for future advancements in this dynamic field.
State-of-art of in situ observations of inclusion agglomeration at steel/Ar and steel/slag interfaces: a review of recent development on experimental and theoretical studies
Authors: Wang Yi , Fu Jian-xun , Kumar Deepoo , Wang Qiang , Yang Hong-liang , Mu Wang-zhong
Published: February 2025

Cleanliness control of advanced steels is of vital importance for quality control of the products. In order to understand and control the inclusion removal during refining process in molten steel, its motion behaviors at the multiple steel/gas/slag interfaces have attracted the attention much of metallurgical community. The recent development of the agglomeration of non-metallic inclusions at the steel/Ar and steel/slag interfaces has been summarized, and both the experimental as well as theoretical works have been surveyed. In terms of in situ observation of high-temperature interfacial phenomena in the molten steel, researchers utilized high-temperature confocal laser scanning microscopy to observe the movement of more types of inclusions at the interface, i.e., the investigated inclusion is no longer limited to Al2O3-based inclusions but moves forward to rare earth oxides, MgO-based oxides, etc. In terms of theoretical models, especially the model of inclusions at the steel/slag interface, the recent development has overcome the limitations of the assumptions of Kralchevsky–Paunov model and verified the possible errors caused by the model assumptions by combining the water model and the physical model. Last but not least, the future work in this topic has been suggested, which could be in combination of thermal physical properties of steels and slag, as well as utilize the artificial intelligence-based methodology to implement a comprehensive inclusion motion behaviors during a comprehensive metallurgical process.
Projective tensor products where every element is norm-attaining
Authors: García-Lirola Luis C. , Guerrero-Viu Juan , Rueda Zoca Abraham
Published: February 2025

In this paper we analyse when every element of

$$X{\widehat{\otimes }}_\pi Y$$

X

⊗
^

π

Y

attains its projective norm. We prove that this is the case if X is the dual of a subspace of a predual of an

$$\ell _1(I)$$

ℓ
1

(
I
)

space and Y is 1-complemented in its bidual under approximation property assumptions. This result allows us to provide some new examples where X is a Lipschitz-free space. We also prove that the set of norm-attaining elements is dense in

$$X{\widehat{\otimes }}_\pi Y$$

X

⊗
^

π

Y

if, for instance,

$$X=L_1(\mu )$$

X
=

L
1

(
μ
)

and Y is any Banach space, or if X has the metric

$$\pi $$

π

-property and Y is a dual space with the RNP.
A quantitative model of hierarchical product design
Authors: Wöhr Ferdinand , Königs Simon , Stanglmeier Max , Zimmermann Markus
Published: February 2025

Analysing hierarchical design processes is difficult due to the technical and organizational dependencies spanning over multiple levels. The V-Model of Systems Engineering considers multiple levels. It is, however, not quantitative. We propose a model for simulating hierarchical product design processes based on the V-Model. It includes, first, a product model which structures physical product properties in a hierarchical dependency graph; second, an organizational model which formalizes the assignment of stakeholder responsibility; third, a process model which describes the top-down and bottom-up flow of design information; fourth, an actor model which simulates the combination of product, organization and process by using computational agents. The quantitative model is applied to a simple design problem with three stakeholders and three separate areas of responsibility. The results show the following phenomena observed in real-world product design: design iterations occur naturally as a consequence of the designers’ individual behaviour; inconsistencies in designs emerge and are resolved. The simple design problem is used to compare point-based and interval-based requirement decomposition quantitatively. It is shown that development time can be reduced significantly by using interval-based requirements if requirements are always broken down immediately.
Kymry, Walenses, Brytaniaid, Britones: Naming the Welsh in the Middle Ages
Authors: Thomas Rebecca
Published: February 2025

This article surveys how the Welsh and their territory have been described, from the early Middle Ages to the present. It begins by examining the terms used by Welsh writers in the early medieval period, before proceeding to consider English nomenclature and the important shift from Brit(t)ones to Walenses in the twelfth century. This shift is re-examined through the lens of the Vita Griffini, which reveals the political motivations behind the increasing focus on Wales and the Welsh. Despite this development in nomenclature, the island of Britain remained central to the identity of the Welsh. This is evident in vernacular texts, especially poetry, and this article explores the different names used in this context. It concludes with a brief foray into the early modern period, ultimately illustrating the continued relevance and significance of the identities fashioned in the early Middle Ages to writers in subsequent centuries.
The place of deemed fulfilment of condition
Authors: Chu Jonathan L T
Published: February 2025

Where, on the face of a contract, the existence of a debt is conditional on the occurrence of a particular fact, and that fact has not occurred, because the person who promised payment has prevented it from occurring, does the debt arise nevertheless on the notion that the condition is then to be deemed fulfilled? In King Crude Carriers SA v Ridgebury November LLC,1 a unanimous Court of Appeal, reversing the judge, endorsed the effect of that notion while appearing to resituate it as a matter of contractual construction, based upon the objective intention of the contracting parties. That would be a step in the right direction. The precise nature of that notion remains murky, however, and would profit from further clarification.
The Melakartas and the ‘République Modale’: Naturalizing Indian Scales in French Musical Modernism
Authors: ASIMOV PETER
Published: February 2025

The zeal for ‘modality’ in French modernist composition drew sustenance from the Indo-European hypothesis (or ‘Aryan myth’) of a linguistic-turned-‘racial’ patrimony linking India, Greece, and Europe, prevalent in Francophone intellectual, including musicological, discourse. Against this backdrop, the central case study traces how the Karnatic melakarta system of rāga classification travelled from Southern India, via British imperial networks, to French universities and conservatoires, whereupon it found widespread interest among composers and pedagogues including Roussel, Emmanuel, Tournemire, and Dupré. Yet the melakartas’ enduring imprint upon French music is found not simply in the use of individual scales, but in the premise of a fecund ‘modal republic’, inspired by the system’s generative logic and resonant in the rationalized modalism of the 1920s and ’30s, including Messiaen’s ‘modes of limited transposition’. The article concludes by proffering a novel conceptualization of the entanglements between Karnatic and French scale systems (and epistemologies of music) in the early twentieth century.
Factors affecting the impact of Popillia japonica Newman, 1841 (Coleoptera: Scarabaeidae) on grapevine in Northwestern Italy
Authors: Lessio Federico , Lioy Simone , Colombo Michele , Alma Alberto
Published: February 2025

The relationships between the Japanese beetle (JB) Popillia japonica Newman, 1841 and the grapevine agroecosystem were investigated in Piedmont in 2020 and 2021, to assess the impact of the species and its distribution within vineyards in relation to the proximity of environmental risk factors. Grubs were sampled by soil coring in the inter-rows of vineyards, whereas both adult beetles and defoliation were counted directly on grapevine plants. The presence of spatial autocorrelation was assessed and the influence of environmental variables (distance from woodlands, meadows and the margin of the vineyard, soil parameters, year of sampling, and year of first detection of the JB) was evaluated through generalized linear mixed models. Beetles and defoliation were more clustered at the edges of vineyards, whereas grubs were localized in few hot spots, generally close to meadows. Spatial autocorrelation was weaker for grubs with respect to adults and defoliation. Grub density depended on distance from meadows, and partially on soil features. Adults abundance was influenced by the proximity to meadows, woodlands, and their presence was clustered at the margin of vineyards. The JBs seem to rely on grapevine mainly as a food source rather than a reproductive site, preferring meadows for egg-laying: therefore, pest management in vineyards should be more focused on adult beetles rather than larvae in the vineyard inter-rows.
Toxocara canis infections in mice: from subtle to severe consequences in 100 weeks
Authors: Bernardová Nicol , Novák Jan , Fan Chia-Kwung , Kolářová Libuše , Chanová Marta
Published: February 2025

Toxocara canis is a widespread parasite of canids with a wide range of paratenic hosts, but also one of the overlooked agents causing nervous system infections of humans. Previous experimental infections of mice demonstrated the impact of high infection doses of larvae on neurobehavioral disorders and pathological changes. In contrast to previous studies, we aimed to investigate the long-term (up to 100 weeks) impact of low- to high-dose infection in mice. We focused on their physical condition, motor skills, and the accompanying pathologies in the brain. Three groups of BALB/c mice were infected with 10, 100, and 1000 T. canis larvae/mouse and specific anti-T. canis excretory-secretory antigens immunoglobulin G antibody response, general condition, and motor skills were tested in defined intervals within 100 weeks after infection. The number of larvae in selected organs was assessed and the pathological changes in the brain were studied histologically. As a result, subtle to severe impairments in general condition and motor skills were detected, with generally earlier onsets occurring the higher the infection dose was. The specific immunoglobulin G antibody levels corresponding to the infection dose were detected in all infected groups. Necrosis, cellular infiltrations, and foamy cells developed in moderate- and high-infection dose mice, in contrast with hemorrhages detected in all groups. This study demonstrated the long-term negative impact of T. canis infection on the paratenic host, particularly at moderate and high infectious doses. Although pathological changes in the brain were observed even in low-infection dose mice, their physical and motor condition was comparable to the control group.
Cuban-style Salsa: Intersections of Tourism-led Entrepreneurship and Dancing Personal Development
Authors: Ana Ruxandra
Published: February 2025

This article is an anthropological exploration of the role of dance in tourism-led entrepreneurship and tourism-led mobilities in Cuba. Based on ethnographic research and employing an autoethnographic lens, the article examines the imaginaries and gendered performances of Cubanness that play out in touristic settings as part of dance trips organized on the island for international tourists. Women are the main target audience for these dance programs, which oftentimes reveal the reproduction of racial stereotypes that contributed to the growing popularity of Cuba as a tourist destination. Dance teachers come to establish a broad spectrum of relations that are influenced by inequalities of resources and unequal access to mobility, since it is the (usually) white European and North American dancing tourists who take up space as central dancing figures, co-creating the cultural script that fetishizes Cuban Black bodies, especially in settings such as salsa schools or popular dance venues.
Crossover and Commercial Dance: Race, Class and Capitalism on The Jacksons Variety Show
Authors: Bergman Elizabeth June
Published: February 2025

This article argues that “crossover”– a recording artist's movement across the racialized boundaries of commercial music genres and the attainment of a broader consumer base– is central to the history and production logic of the U.S. commercial dance industry. By framing the televised variety show The Jacksons (1976–1977) as a formative production experience for Michael and Janet Jackson and situating it within a genealogy of popular dance on commercial television, I examine how racial and class signifiers were used to appeal to different demographics, highlighting the historical lineages and capitalist foundations of the U.S. commercial dance industry.
Contemporary Dance on Native Land: Indigenous Solidarity in the Choreography of Ananya Dance Theatre
Authors: Williams Alessandra Lebea
Published: February 2025

Ananya Dance Theatre generates a framework for “contemporary dance” as choreography which enacts its solidarity with the land of Native peoples. Artistic director Ananya Chatterjea mobilizes her contemporary aesthetic, “Yorchhā,” through the company's alliance with Indigenous peoples’ worldviews on land and water protection, especially through their relations with Dakota and Anishinaabe persons. Dance analysis of the pieces “Moreechika: Season of Mirage” (2012), “Shaatranga: Women Weaving Worlds” (2018), and “Shyamali: Sprouting Words” (2017) shapes contemporary dance through its engagement with Native persons’ caretaking labor for the environment and the position of these relations in the choreography. A practice of humility emerges as the cornerstone of solidarity in contemporary dance due to the necessity for longstanding Native invitation and engagement, Indigenous narratives and embodiment in the dance pieces, and lessons learned from the pitfalls in intersecting techniques such as Ananya Dance Theatre's with Native people's lifeways and knowledges.
Knowledge and perceptions of the southern river otter (Lontra provocax), an elusive endangered species in Tierra del Fuego (Argentina)
Authors: Claverie Alfredo Ñ , Anderson Christopher B , Di Gallo Agustina C , Valenzuela Alejandro EJ
Published: February 2025

The elusive southern river otter (Lontra provocax; huillín in Spanish) is critically endangered in the Argentine portion of Tierra del Fuego, and low social awareness may be one of the major threats to its conservation. Our survey of local residents’ knowledge and valuation of the huillín showed that only 14% recognized photographs of the species, almost half did not know that it is endangered and most erroneously thought it was an introduced species. Greater knowledge about the huillín was related to higher respondent education levels. Younger and more knowledgeable residents valued the species more for ecological and relational reasons; its instrumental value was considered least important. More communication should be targeted at older people and groups not directly interacting with nature via informal education methods, including combining positive messages about the huillín and other native species with ongoing outreach efforts warning about biological invasions. Understanding perceptions and valuations of biodiversity can make conservation efforts more effective and inclusive.
Wie geht Beziehung?
Authors: Donatsch Ursina
Published: February 2025

Worauf kommt es beim Daten wirklich an? Warum haben Paare immer wieder denselben Streit? Was sind die größten Hürden beim Zusammenziehen? Warum sind manche Menschen monogam, während andere es nicht sind?Die Paartherapeutin Ursina Donatsch hat in ihrer langjährigen Praxis unzählige Fragen zu den unterschiedlichsten Beziehungsthemen gehört und beantwortet. Dieses Buch ist eine Sammlung dieser Fragen und ihrer Antworten – prägnant, fundiert und praktisch anwendbar.Und das Beste daran? Sie müssen das Buch nicht von Anfang bis Ende lesen. Sie können es jederzeit zur Hand nehmen, eine Frage herauspicken und sofort Antworten und Anleitungen finden, die Ihnen weiterhelfen. Es ist so konzipiert, dass es Ihnen schnelle und leicht umsetzbare Hilfestellungen bietet, egal wo Sie sich gerade in Ihrem Beziehungsleben befinden.
Narrative Exposure Therapy (NET) For Survivors of Traumatic Stress
Authors: Schauer Maggie , Neuner Frank , Elbert Thomas
Published: February 2025

The new edition of the original Narrative Exposure Therapy manual is full of new and valuable information on how to use this effective, short-term, culturally inclusive intervention with survivors of multiple and complex trauma

Written by the originators of narrative exposure therapy
Fully updated 3rd edition
Step-by-step guidance through NET

Extensive evidence shows that six to twelve sessions of Narrative Exposure Therapy (NET) can be sufficient to provide considerable relief from events such as organized violence, torture, war, rape, and childhood abuse. The new manual is even more clearly structured and easy-to-follow, and includes new figures that help illustrate and guide the reader through the steps of NET. The theoretical sections offer a solid basis for carrying out the therapeutic intervention. The reader is then shown the NET approach step by step, with robust and straightforward practical advice and tools, including how to deal with challenging situations, e.g., how to go deeper when faced with the challenging dynamics of remembering trauma, and how to manage dissociation, avoidance, strong emotions, lost memories, or the sudden emergence of unexpected recollections from the past. NET therapy conversations and resulting narrations from trauma scenes demonstrate the level of Narrative Exposure details required. Finally, the importance of reading back the testimony to the individual is explained.
A new section on the variations of NET details how to offer KIDNET for children and young people, FORNET for victims of trauma who are perpetrators of violence, NETfacts for communities, and ElderNET for older adults as well as online NET (eNET). Experienced therapists also get an idea of how NET is typically trained and how to facilitate NET exercises. Downloadable resources for use in clinical practice include handouts, examples of narrations, and a checklist for adverse life events.
This book is an invaluable resource for clinical psychologists, psychotherapists, psychiatrists, counselors, crisis workers, social workers, health workers, and physicians.
Impact of Internal Tides on Distributions and Variability of Chlorophyll‐a and Nutrients in the Indonesian Seas
Authors: Capuano T. A. , Koch‐Larrouy A. , Nugroho D. , Zaron E. , Dadou I. , Tran K. , Vantrepotte V. , Allain D.
Published: February 2025

Internal tides (ITs) in the Indonesian Seas were largely investigated and held responsible for strong water mass transformation and intense surface cooling. Here, we evaluate the ITs' impact on chlorophyll‐a through a coupled INDESO ocean‐biogeochemical model which is compared with in situ data and satellite products. The results show that explicit tides' inclusion within the model improves the representation of chlorophyll‐a and nutrients. Previous studies highlighted that tides at spring‐neap cycle cool the surface water by 0.2°C. Our current results show increases of chlorophyll‐a by 0.2 up to 5 × 10−7 mg Chl m−3 (in log10) at ITs' generation sites (Sangihe, Ombai, Banda, and Halmahera Straits) and over the shallow Australian plateau and Java Sea, where barotropic tidal friction is high (Zaron et al., 2023, https://doi.org/10.5194/os‐19‐43‐2023). In addition, maxima of chlorophyll‐a concentration have a spring‐neap tides pulse in good agreement with ocean color images. We use INDOMIX in situ vertical diffusivities in a 1D diffusion model to explain the biogeochemical tracers' transformation within the Halmahera Sea and to estimate the nutrients' turbulent flux. We find an associated increase in new production of ∼25% of the total and an increase in mean chlorophyll‐a of ∼30%. These findings support the idea of enhanced surface mixing capable of providing cold and nutrient‐rich water favorable for the phytoplankton growth. Hence, we confirm the key role of ITs in shaping vertical distribution and variability of chlorophyll‐a, along with nutrients and oxygen, in the Indonesian archipelago at the hotspots of intensified mixing where strong ITs are found.
Merging Recent Mean Sea Surface Into a 2023 Hybrid Model (From Scripps, DTU, CLS, and CNES)
Authors: Laloue A. , Schaeffer P. , Pujol M.‐I. , Veillard P. , Andersen O. , Sandwell D. , Delepoulle A. , Dibarboure G. , Faugère Y.
Published: February 2025

In this paper, we compute a new hybrid mean sea surface (MSS) model by merging three recent models, CNES_CLS22, SCRIPPS_CLS22, and DTU21, and taking advantage of their respective features. The errors associated with these models were assessed using sea level anomalies for wavelengths ranging from 15 to 100 km from Sentinel‐3A (S3A), SWOT KaRIn during its calibration phase and ICESat‐2 in the Arctic ice‐covered regions. The variance of the error associated with this new Hybrid23 MSS is estimated at 0.15 ± 0.04 cm2 with S3A. The greatest improvements observed on S3A sea level anomalies are mainly located in coastal regions and along geodetic structures: on average, the error is reduced by 23% within 200 km along the coast and by 35% in the Indonesian region compared with SCRIPPS_CLS22. Despite these improvements, the MSS error still impacts significantly sea level anomalies computed from altimetry: it explains 15% and 18% of the S3A and SWOT KaRIn respective global variance. It becomes predominant (>30%) if we consider the shorter wavelengths ([15, 30 km]). CNES_CLS15 (Pujol et al., 2018, https://doi.org/10.1029/2017jc013503), older, explains up to 88% of the variance of SWOT KaRIn at these wavelengths. MSS errors have become a major limiting factor to the accuracy of sea level anomalies, and hybridization even adds sub‐mesoscale errors. SCRIPPS_CLS22 and DTU21 also remain better in certain regions of the North Atlantic above 60°N and in Arctic coastal areas. Finally, many efforts are still required to develop the MSS to a new level of precision, which we could soon achieve with SWOT KaRIn during the scientific phase.
Simulation of ULF Wave Modulated Electron Precipitation During the 17 March 2015 Storm
Authors: Patel Maulik , Hudson Mary , Kress Brian , Qin Murong
Published: February 2025

Ultra Low Frequency (ULF) waves play an important role in radiation belt dynamics, modulation of higher frequency wave modes and energetic particle precipitation. We investigate the effects of ULF waves on electron precipitation using a global magnetohydrodynamic (MHD) model and a test particle code. ULF waves are simulated using the Lyon‐Fedder‐Mobarry (LFM) global MHD model coupled to the Rice Convection Model with solar wind parameters provided as upstream boundary conditions. The MHD fields are used to trace electron trajectories as test particles in the Dartmouth rbelt3d model (Kress et al., 2007, https://doi.org/10.1029/2006JA012218). We simulate the 17 March 2015 storm, the largest geomagnetic storm of Solar Cycle 24 with a Dst of −223 nT, to examine electron precipitation associated with recurring ULF oscillations. The simulation results show that the initial bipolar electric field oscillation observed by Van Allen Probes causes energy dependent electron acceleration and inward radial transport, while the loss cone size increases on the dayside due to magnetopause compression causing precipitation loss across all energies. The subsequent ULF oscillations are more effective in producing precipitation for higher energy electrons that are drift phase bunched due to the initial electric field impulse, with loss continuing to occur on the dusk side where electrons drift in phase with anti‐sunward propagating ULF waves.
Modeling the Magnetospheric 3D X‐Ray Emission From SWCX Using a Cusp‐Magnetosheath Emissivity Model
Authors: Wharton S. J. , Carter J. A. , Sembay S. , Soobiah Y. , Nitti S. , Sun T. R.
Published: February 2025

A major challenge in solar‐terrestrial physics is to understand the large‐scale dynamics of planetary magnetospheres, such as the motion of the Earth's magnetopause. Currently, a combination of in situ measurements and numerical modeling has been used to address this challenge, but no global imaging has been available. The discovery of soft X‐rays by the solar wind charge exchange (SWCX) process offers an opportunity to image the emitted X‐ray photons. The SMILE mission, due for launch in late 2025, will carry a wide field of view soft X‐ray telescope designed to observe emission from the magnetosheath and cusps. As no emission is expected from within the magnetosphere, it is expected that the magnetopause boundary will be observable from changes in X‐ray intensity across the boundary. Extracting the 3D magnetopause boundary from the 2D X‐ray images is a challenging task and several methods have been developed to model it. One method is to create a 3D emissivity model and adjust its parameters to fit the 2D X‐ray image. In this paper, we develop a Cusp and Magnetosheath Emissivity Model (CMEM) and compare its performance to a previous model that did not include the cusps. We find CMEM has an improved fit to emissivity simulations for a wide range of solar wind densities, but that a poor choice of initial parameters can generate unphysical fits in both models. We propose and verify a method to resolve this that uses the upstream solar wind density to constrain some of the initial parameters.
Drivers of Tropical Cyclone—Induced Ocean Surface Cooling
Authors: Looney Lev B. , Foltz Gregory R.
Published: February 2025

Ocean conditions are known to play a critical role in the intensification of tropical cyclones (TCs). However, the relative roles of ocean temperature and salinity stratification for ocean mixing and TC‐induced sea surface temperature (SST) cooling have remained unclear. Furthermore, there has been limited quantification of which factors, in terms of TC characteristics and prestorm ocean state, are the most important in controlling the amount of cooling. To investigate the mechanisms that control the amount of ocean cooling under a TC in the open ocean, we use a one‐dimensional mixed layer model initialized with a variety of realistic oceanic profiles and forced with different simulated tropical cyclones. We then compare our findings to observations and reanalyses. Results consistently show that the thermodynamic effect (changes in the vertical temperature gradient with the density gradient held constant) is 2–3 times that of the mixing effect (changes in density stratification with temperature stratification held constant) and that translation speed and storm size are the two most important factors for SST cooling, followed by temperature stratification. These results emphasize the often overlooked role of storm size, which increases the residence time of high winds. We also investigate the potential predictability of TC‐induced SST cooling using TC and ocean predictors in a linear regression model. It is found that this simple method, trained on observations, performs as well as more complex methods.
The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development
Authors: Mukhopadhyay Pralay , Abdullah Hesham A. , Opalinska Joanna B. , Paka Prani , Richards Eric , Weisel Katja , Trudel Suzanne , Mateos Maria-Victoria , Dimopoulos Meletios Athanasios , Lonial Sagar
Published: February 2025

Patients with relapsed/refractory multiple myeloma (RRMM) have a poor prognosis and a need remains for novel effective therapies. Belantamab mafodotin, an anti–B-cell maturation antigen antibody-drug conjugate, was granted accelerated/conditional approval for patients with RRMM who have received at least 4 prior lines of therapy, based on response rates observed in DREAMM-1/DREAMM-2. Despite the 41% response rate and durable responses observed with belantamab mafodotin in the Phase III confirmatory DREAMM-3 trial, the marketing license for belantamab mafodotin was later withdrawn from US and European markets when the trial did not meet its primary endpoint of superiority for progression-free survival compared with pomalidomide and dexamethasone. This review reflects on key lessons arising from the clinical journey of belantamab mafodotin in RRMM. It considers how incorporating longer follow-up in DREAMM-3 may have better captured the clinical benefits of belantamab mafodotin, particularly given its multimodal, immune-related mechanism of action with responses deepening over time. A non-inferiority hypothesis may have been more appropriate rather than superiority in the context of a monotherapy versus an active doublet therapy. Further, anticipation of, and planning for, non-proportional hazards arising from response heterogeneity may have mitigated loss of statistical power. With the aim of improving the efficacy of belantamab mafodotin, other Phase III trials in the RRMM development program (DREAMM-7 and DREAMM-8) proceeded to evaluate the synergistic potential of combination regimens in earlier lines of treatment. The aim was to increase the proportion of patients responding to belantamab mafodotin (and thus the likelihood of seeing a clear separation of the progression-free survival curve versus comparator regimens). Protocol amendments reflecting DREAMM-3 learnings could also be implemented prospectively on the combinations trials to optimize the follow-up duration and mitigate risk. The wider implications of the lessons learned for clinical research in RRMM and in earlier treatment settings are discussed.