bluuebunny/crossref_metadata_2025 huggingface dataset:
Spina bifida and cardiorespiratory profile: the impact of leisure sport activities on physical fitness
Authors: Monti Riccardo , Mariani Francesco , Mastricci Rosanna , Nifosì Francesco Maria , Palmieri Vincenzo , Gravina Ester Manes , Capriati Margherita , Rendeli Claudia
Published: August 2023

Purpose
The aim of the present study is to evaluate a population of young patients affected by Spina Bifida (SB) to describe their cardiorespiratory function and bone mineral density profile, analysing any differences between people performing and those who do not perform sports activity. The study also aimed to rule out possible congenital heart disease associated with spina bifida, considering the common origin of certain cardiac structures with those found to be altered in SB patients.
Methods
Thirty-four young patients, aged between 12 and 22 years, diagnosed with spinal dysraphism (SD), have been clinically described and, in order to evaluate their physical fitness, functional capacity and bone mass, almost all of them underwent a complete cardiorespiratory assessment, including Electrocardiogram (ECG), Echocardiogram, Cardiopulmonary Exercise Test (CPET); body composition analysis, using Bioimpedance Analysis (BIA) and Dual Energy X-ray Absorptiometry (DEXA), as well as the estimation of Bone Mineral Density (BMD) with Computerized Bone Mineralometry (CBM).
Results
Collected data demonstrated that only 35% of the subjects practiced physical activity during the week. BMI and percentage FM values were pathological in at least 50% of the population. On cardiological investigations (ECG and echocardiogram), no significant alterations were found. In all patients who performed CPET (79.4%), pathological values of the main functional capacity parameters were revealed, especially peak oxygen consumption (VO2 peak), even when corrected for BCM or FFM estimated at BIA and DEXA respectively. In the CBM analysis, out of 27 patients in whom the femoral T-score was evaluated, a condition of osteopenia was revealed in 40.7% of the patients (11/27) and osteoporosis in 18.5% (5/27); out of 27 patients in whom the lumbar T-score was evaluated, 37% of the patients showed osteopenia (10/27) and 29.6% osteoporosis (8/27). When the comparison between exercising and non-exercising patients was performed, the only statistically significant difference that emerged was the median lumbar T-score value, which appeared lower in the group not performing physical activity (p = 0,009).
Conclusions
The extensive cardiorespiratory evaluation, including CPET, of our cohort of spina bifida patients showed altered values of the main parameters related to cardiorespiratory fitness and is the only study in the literature that analysed bone mineralisation values in physically active and sedentary spina bifida patients and demonstrated a statistically significant difference. Furthermore, it is the only study to date that investigated the possible association of congenital heart diseases with SD, without demonstrating the existence of pathological conditions.
The Second-minimum and Second-maximum Value of Sombor Index in Unicyclic and Bicyclic Graphs
Authors: tan huan , zhao biao
Published: August 2023

Gutman proposed a topological index called the Sombor index, which was defined as \(SO(G)=\sum_{uv\in E(G)}\sqrt{(d_G(u))^2+(d_G(v))^2}\), where \(d_G(v)\) is the degree of the vertex \(v\) in graph \(G\). In this paper, we determine the second-minimum and second-maximum value of the Sombor index over all the unicyclic and bicyclic graphs.
Improving precise point positioning (PPP) performance with best integer equivariant (BIE) estimator
Authors: Yang Yuze , Zhou Feng , Song Shuli
Published: August 2023

Precise point positioning (PPP) technology is capable of providing global high-precision positioning services, but its main application bottleneck is the long convergence time. Accurate and reliable carrier phase ambiguity resolution (AR) is a primary approach to accelerate PPP convergence and improve its accuracy. The best integer equivariant (BIE) method, known for its superior performance in minimizing mean square error (MSE), is gradually being adopted for PPP-AR. This study examines key aspects of the BIE algorithm, including the determination of the optimal number of candidate sets and how the number of candidates evolves during convergence. The performance of the BIE algorithm is evaluated by utilizing both post-processing products and real-time products generated at the French CNES (Centre National D'Etudes Spatiales) with static station data. The experimental results unequivocally demonstrate that the BIE algorithm significantly improves both positioning accuracy and convergence speed compared to the least-squares ambiguity decorrelation adjustment (LAMBDA) algorithm in PPP-AR. Furthermore, a verification experiment using real ship-borne dynamic data confirms the exceptional robustness of the BIE algorithm.
Scale-dependent habitat selection is shaped by landscape context in dispersing white-tailed deer
Authors: Stephens Ryan B. , Millspaugh Joshua J. , McRoberts Jon T. , Heit David R. , Wiskirchen Kevyn H. , Sumners Jason A. , Isabelle Jason L. , Moll Remington J.
Published: August 2023

Context. Identifying how animals select habitat while navigating landscapes is important for understanding behavioral ecology and guiding management and conservation decisions. However, habitat selection may be spatially and temporally plastic, making it challenging to quantify how species use resources across space and time.
Objectives. We investigated how landscape context and dispersal shape habitat selection at multiple spatial scales in white-tailed deer (Odocoileus virginianus).
Methods. Using step-selection functions, we quantified habitat selection of landcover and topographic covariates at three spatial scales for juvenile males during three movement periods (before, during, after dispersal) in two regions of Missouri, USA — a fragmented, low forest cover region with rolling hills, and a forested, topographically variable region.
Results. Although selection for forest cover increased after dispersal in both regions, deer selected forest cover at smaller spatial scales in the fragmented, low forest cover region. This result indicates scale of selection was dependent on forest availability and configuration with deer likely perceiving landscapes differently across their distribution. Functional responses to topography differed in magnitude and direction between regions with deer avoiding roads and selecting valleys in the rolling hills region (especially during dispersal) while showing no response to roads and selecting for ridgelines (during dispersal) in the topographically variable region. This result suggests movement behavior is strongly dependent on topography.
Conclusions. Although deer may select habitats similarly among regions, landscape context and movement period shape the scale, strength, and direction of selection. This result has important implications for how deer use landscapes across different regional contexts.
Research on Deep Learning Based Genetic Intelligent Identification Method for Historical Buildings: A Case Study of Chinese Baroque Architecture in Harbin, China
Authors: Shao Long , Sun Jianqiao
Published: August 2023

The protection of historical buildings is limited by low-quality style imitation and large-scale demolition and reconstruction, and the work process requires a high investment of human and material resources, which restricts the inheritance and development of this material cultural heritage. How to achieve precise monitoring and protection of historical building style is a key issue that needs to be urgently solved. The gene of historical architecture is the basic unit that controls the style of historical architecture. Identifying the gene of historical architecture is to identify the decisive factor that controls the style of historical architecture, which is of great significance for precise monitoring and protection of the style of historical architecture. At present, there are subjective qualitative, difficult to quantify, poor recognition accuracy, and low efficiency in reasoning and recognition in research on genetic identification of historical buildings. Therefore, this article takes the Chinese Baroque architecture in Harbin, China as an example, drawing on the principles of biological gene recognition, referring to the methods of architectural gene recognition in cultural geography and architecture, and using improved U-net models, traditional U-net models, FCN models, and Efficient Net models that incorporate channel attention mechanisms to intelligently identify historical building genes, obtaining the optimal intelligent recognition method for historical building genes based on deep learning. Research has shown that the accuracy of the improved U-net model incorporating channel attention mechanism is 0.69, which is 0.04, 0.07, and 0.01 higher than traditional U-net (0.65), FCN (0.62), and Efficient net (0.68), respectively. Therefore, the improved U-net model is the optimal method for intelligent identification of historical building genes. Research can provide new tools and methods for the intelligent identification of historical building genes.
Thermoring Basis for the Heat Inactivation in TRPV1
Authors: Wang Guangyu
Published: August 2023

Transient receptor potential vanilloid-1 (TRPV1) in mammals exhibits the temperature-dependent inactivation in response to repeated or constant heat stimuli. However, the underlying structural factors or motifs are unresolved. In this computational study, the graph theory-based grid thermodynamic model was employed to reveal how the temperature-dependent non-covalent interactions as identified in the 3D structures of TRPV1 could develop a systemic fluidic grid-like mesh network with topological grids constrained as the thermo-rings to govern the heat inactivation from open and pre-open closed states in different temperature ranges. The results showed that the heat-evoked melting of three biggest grids in different gating states was responsible for the TRPV1 activity starting at 43°C and peaking at 56°C and ending at 61°C. While the second biggest grid controlled a reversible inactivation from the open state between 56°C and 61°C, a smaller grid governed another irreversible inactivation from the pre-open closed state from 43°C to 61°C. Thus, two distinct inactivation pathways of TRPV1 may be involved in a protective mechanism in mammals against noxious heat.
Effect of temperature and salinity on in-vitro population growth of copepode Oithona (Copepoda: Cyclopoidae). Temperature-salinity Oithona culture
Authors: Lambraño Katrina Medina , Forero Adriana Rodríguez
Published: August 2023

The marine copepods culture has been considered a great resource for feeding in marine aquaculture. Oithona is the most abundant genus in the oceans and that is why they are the largest contributors of live prey in fish larvae. The present study aimed to identify the influence of temperature and salinity on the population growth of Oithona sp. under laboratory conditions. Copepods were cultivated (n: 15 ind/200 ml in three experimental temperatures: 21, 26, 31°C and in three salinities: 20, 30, and 40‰), which were monitored and adjusted daily. Copepods were fed based on a microalgae culture Isochrysis sp. at a continuous density of 600.000 cel/ml. for 15 days. At the end of the experiment, Oithona sp presented significant statistical differences (p < 0.05), in population growth, with a higher population density at 40‰ (8.040 ± 6.265.2 ind/ 200ml), at a temperature of 31°C. Also, it was shown that the variable salinity alone did not influence the population growth of the copepod, while, if it was related to the water temperature, it presents statistically significant differences (p < 0.05), in all possible combinations. We concluded that Oithona sp. can be well adapted to higher temperature and salinity conditions in which the optimal salinity and temperature variables rate is 31°C and 40‰ to reach a higher development. These conditions improve the rate of reproduction, population growth, and its development in culture.
Neutrophil-to-Lymphocyte Ratio Associated with Symptomatic Saccular Unruptured Intracranial Aneurysm
Authors: Zheng De-Xiang , Lv Yi-Yang , Zhang Xiao-Jing , Ye Jie-Shun , Zhang Jian-Xing , Chen Cha , Luo Bin , Yan Dan
Published: August 2023

Background and purpose: Whether symptomatic unruptured intracranial aneurysms (UIAs) lead to change in circulating inflammation remains unclear. This study aims to evaluate the role of hematological inflammatory indicators in predicting symptomatic UIA.
Methods: Adult patients diagnosed with saccular intracranial aneurysm from March 2019 to August 2022 were recruited retrospectively. Clinical and laboratory data, including the white blood cells (WBC), neutral counts (NEUT), lymphocyte counts (LYM), and monocyte counts (MONO) of each patient, were collected. The neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) were calculated as NLR = NEUT/LYM, LMR = LYM/MONO, SII = PLT*NEUT/LYM. The hematological inflammatory indicators were compared in symptomatic saccular and asymptomatic UIA patients. Multivariable logistic regression analyses were performed to explore the factors predicting symptomatic UIA.
Results: Eighty-eight UIA patients with a mean age of 57.0 ± 11.6 were included, of which 68.2% were females. The NLR and LMR were significantly associated with symptomatic UIA, and the association remained in small UIAs (<7 mm). The multiple logistic regression analysisshowed that NLR was an independent risk factor for symptomatic UIA. On ROC curve analysis, the optimal cutoff value of NLR to differentiate symptomatic from asymptomatic was 2.38. In addition, LMR was significantly associated with symptomatic UIA smaller than 7 mm.
Conclusion: There was a significant correlation between NLR and symptomatic UIA. The NLR was an independent risk factor for symptomatic UIA.
A Study on the Use Choice and Preference Correlation of Inner Perfume in Korean Women
Authors: Son Younsun , Kwon Ki Han
Published: August 2023

Background
The evaluation questionnaire for Korean women's choice of using inner perfume provided relatively promising results. To evaluate reliability, it is to verify correlation studies of preferences.
Methods
An online survey of 507 Korean women in their 20s and 40s who agreed with the purpose of this study and voluntarily expressed their intention to participate was conducted using SPSS win v25.0 to analyze at a 5% significance level. Exploratory factor analysis was conducted and Cronbach's ⍺ was calculated to test the validity and reliability of the study subjects' perceptions and preferences.
Results
The reason why Korean women use Inner Perfume is because they recognize the smell of the Y zone before and after menstruation to hide unpleasant smells. This is a preference for inner perfumes in improving the quality of life of Korean women, which has a positive effect on their use.
Conclusions
Looking at the variables that affect preference, quality (t = 7.458, p < .001) and advertisements (t = 5.738, p < .001) was found to have a significant positive (+) effect on preference, but brands and prices did not have a significant effect on preference (p > .05). Among the variables that have a significant effect, 'quality (=).308) > Advertising (= In the order of '244), preference was found to have a large influence. Therefore, it means that preference improves as quality and advertisement increase.
Learning Patterns from Biological Networks: A Compounded Burr Probability Model
Authors: Chakraborty Tanujit , Naik Shraddha M. , Chattopadhyay Swarup , Das Suchismita
Published: August 2023

Complex biological networks, comprising metabolic reactions, gene interactions, and protein interactions, often exhibit scale-free characteristics with power-law degree distributions. However, empirical studies have revealed discrepancies between observed biological network data and ideal power-law fits, highlighting the need for improved modeling approaches. To address this challenge, we propose a novel family of distributions, building upon the baseline Burr distribution. Specifically, we introduce the compounded Burr (CBurr) distribution, derived from a continuous probability distribution family, enabling flexible and efficient modeling of node degree distributions in biological networks. This study comprehensively investigates the general properties of the CBurr distribution, focusing on parameter estimation using the maximum likelihood method. Subsequently, we apply the CBurr distribution model to large-scale biological network data, aiming to evaluate its efficacy in fitting the entire range of node degree distributions , surpassing conventional power-law distributions and other benchmarks. Through extensive data analysis and graphical illustrations, we demonstrate that the CBurr distribution exhibits superior modeling capabilities compared to traditional power-law distributions. This novel distribution model holds great promise for accurately capturing the complex nature of biological networks and advancing our understanding of their underlying mechanisms.
Multifunctional cellulose composite films with dual-continuous CNT/BN networks for synchronously enhanced electromagnetic interference shielding effectiveness and thermal conductivity
Authors: Zhang Liang-Qing , Zhou Fang , Shi Qin , Zhang Zheng-Yang , Yang Shu-Gui , Yan Ding-Xiang
Published: August 2023

Multifunctional materials with excellent electromagnetic interference (EMI) shielding effectiveness and thermal conductivity (TC) are an essential guarantee for the rapid advancement of next-generation electronic products. Herein, the three-dimensional porous conductive/thermal network of carbon nanotubes (CNT)/cellulose are prefabricated by freeze-drying. Using "impregnation and high-pressure compression molding", CNT/cellulose-boron nitride/polyvinyl alcohol (CNT/cellulose-BN/PVA) composite films with three-dimensional dual-continuous network structure are constructed to provide a perfect pathway for both electrons and phonons transportation. Comprehensive performance of the composites before and after hot-pressing including the microstructure, electrical conductivity, EMI shielding and thermal conductivity is investigated. Benefiting from the high-pressure compression molding process, the composite is densified and a close contact between fillers is achieved, which effectively improves the electrical and thermal conductivity. The finally obtained CNT/cellulose-BN/PVA composite film exhibits satisfactory EMI shielding performance, high in-plane and cross-plane TC, as well as excellent Joule heating performance, demonstrating enormous potential as high-performance EMI shielding and thermal management materials in practical applications. The significance of this work is to give an inspiration for improving the comprehensive performance of electromagnetic shielding and thermal conductive materials.
Synthesis, crystal structure, and characterization of two new end-to-end 1D pseudohalide bridged manganese(III) complexes
Authors: Mandal Uttam , Rizzoli Corrado , Chakraborty Bikash , Karmakar Srikanta , Roy Swapnadip , Mandal Santanu , Bandyopadhyay Debasis
Published: August 2023

Two new Manganese (III) Schiff base complexes MnL2N3 (1) and MnL2NCS (2) where HL is 4-bromo-2-[(Z)-{[2-(thiophen-2-yl)ethyl]imino}methyl]phenol) were synthesized and characterized by UV–Vis. absorption spectra, FT-IR, photoluminescence (PL) emission spectra, TGA Analyses, and single-crystal X-ray diffraction technique. Structural studies reveal that the metal sites in all complexes are six-coordinated by two phenoxy oxygen and two imine nitrogen atoms of two moles of Schiff base ligand, HL. The geometry around the metal center is twisted octahedral geometry with a MnN4O2 (for 1) and MnN3O2S (for 2) chromophore. Hirshfeld surfaces associated with 2D fingerprint plots have been used to analyze intermolecular interactions in crystal packing. Computational study using Density Functional Theory (DFT) has been done (for 1) to elucidate the structural information and energy gap calculation between HOMO & LUMO. Crystal packing of both complexes shows the interchain π\(\cdots\)π stacking interactions between one-dimensional chains.
Urinary stone composition analysis and clinical assessment of patients in a tertiary urology care centre in eastern India
Authors: Kumar Prem , Ahmad Shamim , Singh Manoj Kumar , Prem Pranjal , Mazumdar Himangshu , Singh Smita
Published: August 2023

Objective
Urinary stones are typical conditions that result in significant morbidity and monetary costs. Analysis of patients with different stones determines the preferred treatment modality and helps decide the preventive measures to avoid stone recurrence. This study aimed to identify the association between patient characteristics with stone type and composition in the eastern region of India.
Material and methods
A super specialty hospital in an eastern Indian city enrolled 1231 cases of urinary stones which were admitted for elective stone removal between January 2015 and November 2022. Patient information was gathered, including demographics, clinical data, dietary habits, water consumption, geographic region, and stone recurrence. An analysis was performed to establish a relationship between these characteristics and the type and composition of stones.
Result
The study found that urinary stones are more common in men, with calcium oxalate being the most prevalent type of stone. Individuals aged 31–40 had the highest incidence of stones, including double-component stones, while single-component and multiple-component stones were most common in those aged 21–30. The kidneys were found to be the most likely origin of stones and the instances of stone recurrence showed a substantial (p = < 0.001) correlation with dietary habits and water intake.
Conclusion
Calcium oxalate is the predominant stone component. The stone recurrence rate factors are correlated with age, gender, food habits, and water intake patterns.
Computer Vision and Machine Learning Based Traffic Scene Perception and Car Driver Injury Assessment
Authors: Wei Sun , Halin Alfian Bin Abdul
Published: August 2023

Traffic scene perception and risk assessment for car drivers is critical to improving road safety. This study aimed to develop a deep supervised learning detector for automotive traffic scenes based on computer vision and machine learning techniques to detect the effects of weather factors and road factors on car drivers and to assess the degree of injury in traffic accidents. The goal of this research was to assess the extent to which motorists are injured in traffic accidents in each traffic scenario by analyzing and evaluating weather factors and road factors. This approach used deeply supervised learning detectors to detect and classify weather and road factors in motor vehicle traffic scenarios using computer vision and machine learning techniques. By processing and analyzing the data, it can determine the relationship between weather and road factors and the extent of injuries sustained by motorists. In addition, the research analyzed the relationship between weather and road factors and the degree of driver injury using a linear regression model. By calculating the regression coefficients, the research can quantify the effect of weather and road factors on the level of driver injury. The experimental results showed that weather and road factors were positively related to the level of injury of motorists. This study provided important insights into car driver risk assessment in traffic scenarios through the evaluation and discussion of deep supervised learning detectors and linear regression models.
Locating the core areas of frontal-parietal network: A systematic review and meta-analysis
Authors: Cai Zhen , Li Jing , Wang Chun , Zhong Yuan
Published: August 2023

Prior published studies indicated the involvement of the frontal parietal (FPN) network in execution of different cognitive functions, but the diversity of functions led to a lack of uniformity in the definition of this complex network system. In the present study, 325 functional magnetic resonance imaging datasets were analysed in order to map the core regions of the FPN based on control signal patterns associated with different cognitive functions. Meta-analysis revealed a bilateral network for different executive control functions. Activation likelihood estimation (ALE) analysis for different effectors within the network revealed high comparable activation intensity and consistent function response to the overall analyses on attention, working memory and cognitive control, respectively, indicating an independence of these findings from potential divergences. On the other hand, ALE contrast analyses on our dataset, as well as meta-analytic connectivity modelling (MACM) analyses on the BrainMap database, indicated that executive control tasks reliably elicit activity in consistent brain areas include dorsolateral prefrontal cortex (dlPFC), medial frontal gyrus (medFG), superior frontal gyrus (sFG), bilateral middle frontal gyrus (mFG), inferior parietal lobule (IPL) and anterior insula. Our findings summarize and refine previous descriptions of the human brain networks related to executive control function. The significant contributions in cognitive function of these areas are also been clarified.
On-Ground Validation of Orbital GNC: Visual Navigation Assessment in Robotic Testbed Facility
Authors: Muralidharan Vivek , Makhdoomi Mohatashem Reyaz , Žinys Augustinas , Razgus Bronislovas , Klimavicius Marius , Olivares-Mendez Miguel , Martinez Carol
Published: August 2023

CubeSats have become versatile platforms for various space missions (e.g. On-Orbit Servicing and debris removal), owing to their low cost and flexibility. Many of these tasks involve proximity operations, requiring precise guidance, navigation, and control (GNC) algorithms. Vision-based navigation is gaining traction for such operations, but extreme lighting conditions in space challenge optical techniques. This paper presents the ground validation of a GNC algorithm designed for autonomous satellite rendezvous, leveraging hardware-in-the-loop (HIL) experiments. The investigation focuses on two key areas. Firstly, the rationale behind the augmenting of the robot workspace (6-Dof UR10e robot + linear rail) to emulate relatively longer trajectories with complete position and orientation states. Secondly, the assessment of the control algorithm in response to uncertain pose observations from the vision-based navigation system. Results indicate increased control costs with uncertain navigation and exemplify the importance of on-ground testing for system validation prior to launch, especially in extreme cases that are typically difficult with software-based testing.
An internally and externally validated nomogram for predicting cancer- specific survival in octogenarians after radical resection for colorectal cancer
Authors: Zhu Junchang , Cen Wei , Zheng Xuzhi , Ye Chenqiao , Guo Feifan , Yan Xialin , Shi Hongying , Ye Lechi , Hu Tingting
Published: August 2023

Purpose
We aimed to develop an elaborative nomogram that predicts cancer-specific survival (CSS) in American and Chinese octogenarians treated with radical resection for CRC.
Method
The patient data of newly diagnosed patients aged 80 years or older who underwent radical resection for CRC from 2010 to 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and then randomly divided into a training cohort and a validation cohort. The patients collected from our hospital were defined as the external validation cohort. Univariate and multivariate Cox regression was used to select independent predictive factors for the construction of a nomogram to predict 1-, 2- and 3-year CSS.
Results
The multivariate Cox regression model identified age, T stage, N stage, perineural invasion, chemotherapy, tumour deposits, carcinoembryonic antigen level, number of lymph node metastases, and number of solid organ metastases as independent predictors of survival. The C-index of the nomogram for 1-, 2- and 3-year CSS was 0.758, 0.762, and 0.727, respectively, demonstrating significant clinical value and substantial reliability compared to the TNM stage. The calibration curve and area under the curve also indicated considerable predictive accuracy. In addition, decision curve analysis demonstrated desirable net benefits in clinical application.
Conclusion
We constructed a nomogram for predicting the CSS of individual octogenarian patients with CRC who underwent radical resection. The nomogram performed better than the TNM staging system in this particular population and could guide clinicians in clinical follow-up and individual therapeutic plan formulation.
Uruguayan dance students: A model to unravel the associations between circadian, sleep, and mood disturbances
Authors: Paz Valentina , Coirolo Natalia , Tassino Bettina , Silva Ana
Published: August 2023

Background: Current evidence supports associations between circadian, sleep, and mood disturbances. However, it is still debated to what extent different chronobiological and mood variables act independently or in synergy to impact health.
Methods: This study assesses how these variables interact to affect depressive symptoms and sleep quality in 26 Uruguayan dancers (age=22.27±2.43) training in the morning (n=9) or in the night shift (n=17). Participants completed the Munich Chronotype Questionnaire, the Pittsburgh Sleep Quality Index, and the Beck Depression Inventory-II.
Results: Participants reported high social jetlag (1.58±1.45h), late chronotypes (05:43±01:35), and poor sleep quality (6.77±2.67), while adequate sleep duration (7.10±1.31h) and minimal depression (7.15±3.62), without differences across shifts. Depressive symptoms increased as sleep quality worsened (F(1,21)=20.66, p<0.001). In addition, sleep duration interacted with the shift to explain depressive mood (F(1,21)=4.06, p=0.057), with participants in the morning shift showing higher depressive symptoms with decreased sleep duration. Furthermore, sleep quality deteriorated as social jetlag increased (F(1,20)=14.82, p=0.001), particularly in more depressed individuals.
Conclusions: Our findings indicate that social, circadian, sleep, and mood variables are inextricably linked in this population of dancers.
Embedding cultural competency and cultural humility in undergraduate pharmacist initial education and training: a qualitative exploration of pharmacy student perspectives
Authors: Robinson-Barella Anna , Tayki Christoper , Chan Hayley KY , Lau Wing Man
Published: August 2023

Background Emphasis has been placed upon embedding equity, diversity and inclusion within the initial education and training of healthcare professionals, like pharmacists. Yet, there remains limited understanding of how best to integrate cultural competence and cultural humility into undergraduate pharmacy student training. Aim To explore the views of pharmacy students to understand perspectives on, and identify recommendations for, embedding cultural competence and cultural humility within pharmacy education and training. Method Semi-structured interviews were conducted in-person between November 2022 and February 2023. Interviews were audio-recorded and transcribed verbatim. Reflexive thematic analysis enabled the development of themes. The COREQ checklist was followed and QSR NVivo (Version 12) facilitated data management. Ethical approval was obtained from the Newcastle University Ethics Committee (reference: 25004/2022). Results Twelve undergraduate pharmacist students, across all years of undergraduate training, were interviewed. Three themes were developed from the data, centring on: (1) recognising and reflecting on cultural competency and cultural humility; (2) gaining exposure and growing in confidence; and (3) thinking forward as a culturally competent pharmacist of the future. Conclusion These findings begin to offer actionable recommendations to align with the updated Initial Education and Training standards from the General Pharmaceutical Council; specifically,howandwhencultural competence teaching should be embedded within the undergraduate pharmacy curriculum. Future research should explore specifics around teaching content, learning environments, and methods of assessment that would be best suited to support the initial education and training of pharmacy students.
Short-term dietary fiber interventions produce consistent gut microbiome responses across studies
Authors: Rodriguez Cynthia I. , Isobe Kazuo , Martiny Jennifer B.H.
Published: August 2023

Background The composition of the human gut microbiome varies tremendously among individuals, making the effects of dietary or treatment interventions difficult to detect and characterize. The consumption of fiber is important for gut health, yet the specific effects of increased fiber intake on the gut microbiome vary across studies. The variation in study outcomes might be due to inter-individual (or inter-population) variation or to the details of the interventions including the types of fiber, length of study, size of cohort, and molecular approaches. Thus, to identify consistent fiber-induced responses in the gut microbiome of healthy individuals, we re-analyzed 16S rRNA sequencing data from 21 dietary fiber interventions from 12 human studies, which included 2564 fecal samples from 538 subjects across all interventions.Results Short-term increases in dietary fiber consumption resulted in highly consistent gut microbiome responses across studies. Increased fiber consumption explained an average of 1.5% of compositional variation (versus 82% of variation attributed to the individual), reduced alpha diversity, and resulted in phylogenetically conserved responses in relative abundances among bacterial taxa. Additionally, we identified bacterial clades, at approximately the genus level, that were highly consistent in their response (increasing or decreasing in their relative abundance) to dietary fiber interventions across the studies.Conclusions Our study is an example of the power of synthesizing and reanalyzing microbiome data from many intervention studies. Despite high inter-individual variation of the composition of the human gut microbiome, dietary fiber interventions cause a consistent response both in the degree of change as well as the particular taxa that respond to increased fiber.
Enhancing students’ agency in learning anatomy vocabulary with a formative intervention design
Authors: Ritchie Helen E. , HEGEDUS ELIZABETH , yang Hongzhi
Published: August 2023

One of the major challenges for health science students is the rapid acquisition of a new vocabulary in anatomy comprising several hundred new words. Research has shown that vocabulary learning can be improved when students are directed to vocabulary strategies. This paper reported a study with a formative intervention design inspired by Vygotsky’s method of double stimulation. In this design, the students were put in a structured situation that invited them to identify the challenges in learning anatomy and then provided them with active guidance and a range of anatomy vocabulary learning strategies that scaffolded them to work out a solution to the challenge and develop their individualized anatomy learning resources. The data were collected from surveys, pre- and post-quiz results, and group discussion transcripts. The results revealed students perceived one of the main challenges in learning anatomy was learning, memorizing and remembering many new words. A key finding in our study was that the formative intervention enhanced students’ agency in creating resources for learning anatomy vocabulary. In addition, the development of their understanding showed a recursive form: from concrete experiences to abstract concepts and then to concrete new practices.
Effect of Antiretroviral Therapy on Body Composition in Patients Living with Human Immunodeficiency Virus: An Observational Study
Authors: Konishi Keiji , Nakagawa Hidenori , Asaoka Tomohiro , Kasamatsu Yu , Goto Tetsushi , Shirano Michinori
Published: August 2023

Background
Increased incidence of lifestyle diseases as side-effects of antiretroviral therapy (ART) have been reported in people living with HIV (PLWH). Few studies have evaluated obesity and hidden obesity in Japanese PLWH and their association with ART. In order to provide more appropriate drug selection and lifestyle guidance, we investigated the relationship between the effects of HIV infection and ART on the body composition of Japanese PLWH.
Methods
PLWH who visited the outpatient clinic and had body composition measured using the body composition analyzer InBody 570 were included in this study. Medications, comorbidities, and blood test data were obtained. Body mass index (BMI), body fat percentage, and skeletal muscle mass index (SMI) were measured.
Results
In this study, 543 patients were included. Body shape groups were classified into a thin group (13), normal weight group (14), hidden obesity group (158), apparent obesity group (14), and obesity group (218). Compared to the normal weight group, the hidden obesity group had a higher prevalence of comorbidities and a lower SMI.
Conclusions
PLWH are more likely to have obesity than the general population, indicating that hidden obesity is common even among those with a normal BMI. It is important to measure body fat percentage along with body weight since hidden obesity can be missed. Further investigation of the effects of ART on body composition is needed.
Effects of Chronotype-tailored Bright Light Intervention on Symptoms and Quality of Life in Breast Cancer Survivors
Authors: Wu Horng-Shiuann , Gao Feng , Davis Jean E. , Given Charles W.
Published: August 2023

Purpose
Bright light therapy holds promise for reducing common symptoms, e.g., fatigue, experienced by individuals with cancer. This study aimed to examine the effects of a chronotype-tailored bright light intervention on sleep disturbance, fatigue, depressive mood, cognitive dysfunction, and quality of life among post-treatment breast cancer survivors.
Methods
In this two-group randomized controlled trial (NCT03304587), participants were randomized to receive 30-min daily bright blue-green light (12,000 lux) or dim red light (5 lux) either between 19:00–20:00 h or within 30 min of waking in the morning. Self-reported outcomes and in-lab overnight polysomnography sleep study were assessed before (pre-test) and after the 14-day light intervention (post-test).
Results
The sample included 30 women 1–3 years post-completion of chemotherapy and/or radiation for stage I to III breast cancer (mean age = 52.5 ± 8.4 years). There were no significant between-group differences in any of the symptoms or quality of life (all p > 0.05). However, within each group, self-reported sleep disturbance, fatigue, and depressive mood, and quality of life-related functioning showed significant improvements over time (all p < 0.01); the extent of improvement for fatigue and depressive mood was clinically relevant. Polysomnography sleep findings showed that number of awakenings significantly decreased (p = 0.011) among participants received bright light, while stage 2 sleep significantly increased (p = 0.015) among participants received dim-red light.
Conclusion
The findings provide some evidence to support using chronotype-tailored light therapy to manage sleep disturbance, fatigue, depressive mood in post-treatment breast cancer survivors. The unexpected symptom improvements among dim-red light controls remain unexplained and requires further investigation.
ClinicalTrials.gov Identifier:
NCT03304587 Study was registered on October 19, 2017.
Mendelian randomization study of inflammatory cytokines and Bell's palsy
Authors: Wu Wenbao , Fan Daofeng , Qiu Jing , Que Binfu , Chen Yangui , Qiu Rui
Published: August 2023

Background
Current research suggests inflammation as a cause of Bell's palsy. However, a large number of patients have not fully recovered even after combined antiviral and glucocorticoid treatment. Consequently, the relationship between inflammation and Bell's palsy remains uncertain.
Methods
We employed a two-sample Mendelian randomization approach using genetic variances of Bell's palsy from the UK Biobank (626cases and 361,141 controls of European ancestry) and inflammatory cytokines from a GWAS summary containing 8,293 healthy participants. We took a series of rigorous quality control steps to select eligible instrumental SNPs closely related to the exposure. In order to make the conclusion more robust and reliable, we employed several robust analysis methods including inverse variance weighted, weighted median, MR-Egger regression, each based on different assumptions in two-sample MR Analysis. We also performed sensitivity analyses, such as MR-Egg regression, MR-PRESSO and leave-one-out, to mitigate concerns of horizontal pleiotropy and heterogeneity.
Results
Our two-sample mendelian randomized study indicates a positive association between tumor necrosis factor-related apoptosis-inducing ligand(TRAIL), interleukin 2(IL-2 ) with Bell's palsy, while revealing a negative correlation between interleukin 12(IL-12)and Bell's palsy.
Conclusions
At the genetic level, IL-2 and TRAIL appear to be potential risk factors for Bell’s palsy. Conversely, IL-12 seems to have a diminishing effect on Bell's palsy, yet the evidence is insufficient and warrants further investigation.
Revisão sistemática da literatura sobre os métodos e os procedimentos para a busca do traçado ótimo de adutoras
Authors: Duarte Armando Dias , Cirilo José Almir , Bezerra Saulo de Tarso Marques
Published: August 2023

Um dos desafios mais urgentes que a humanidade enfrenta diz respeito à gestão das águas. Em todo o mundo, regiões estão lidando com a crescente demanda por água potável, resultando em uma crise de escala global que está modificando a vida das pessoas, a agricultura, a indústria e o meio ambiente. Uma das estratégias adotadas para suprir a demanda hídrica é a construção de adutoras, sistemas que transportam água de fontes hídricas para as regiões consumidoras. A construção de uma adutora não é uma tarefa simples, é necessário considerar diversos fatores, como a topografia do terreno, a distância entre a fonte de água e o destino final, a minimização de impactos ambientais e a eficiência do sistema. É nesse contexto que o presente trabalho tem como objetivo realizar a revisão bibliográfica a respeito sobre métodos e procedimentos na busca por traçados de adutoras.
Análise de propostas didáticas que envolvem a interdisciplinaridade e a contextualização no Ensino de ciências
Authors: Camillo Cíntia Moralles , Gehrke Graffunder Karine , De Souza Timmermann Rafael
Published: August 2023

Este estudo teve como objetivo mapear e analisar as publicações que abordam propostas didáticas envolvendo a interdisciplinaridade e a contextualização no Ensino de Ciências, por meio das plataformas de busca da Biblioteca Digital de Teses e Dissertações, Portal d Periódicos Capes e Google Acadêmico, no período de 2010 a 2020. Trata-se de uma pesquisa exploratória, a partir de uma revisão sistemática da literatura, com análise do tipo de publicação; nível de ensino; região; temática; disciplina de origem; a ocorrência da interdisciplinaridade e da contextualização; propostas didáticas e suas categorias e tendência pedagógica adotada. Os resultados da pesquisa indicam que a maioria dos estudos teve como público-alvo estudantes do Ensino Médio. As propostas didáticas foram organizadas em sequências didáticas, com base na problematização. As atividades ocorreram em formato de seminários e produção de textos, e os recursos mais utilizados foram slides, vídeos, Internet e celulares. As tendências pedagógicas encontradas foram a Tradicional, Renovada Progressivista e Progressista Libertadora. Conclui-se que a pluralidade de propostas didáticas dos estudos analisados propicia a articulação de conhecimentos de áreas distintas e o contato com a Ciência, resultando em um processo no qual o professor tem a oportunidade de refletir, construir e reconstruir as concepções de sua própria prática.
Analysis of Endosulfan Isomers and other Pesticides in Surface Water of the Paraíba do Sul River Basin by Solid Phase Extraction and Comprehensive Two-Dimensional Gas Chromatography Coupled with Time-of-Flight Mass Spectrometry
Authors: Mazza Felipe , dos Santos Isabella , Sampaio Nilo Antônio , Mangelli Luciana , von Mühlen Carin
Published: August 2023

In 2008, there was a large endosulfan spill in one of the most important rivers in southeastern Brazil. However, no studies were found to assess the persistence of endosulfan in this environment. The persistence of endosulfan and its metabolites, in addition to other organochlorine pesticides, was evaluated in water samples collected from the Pirapetinga River and Paraíba do Sul River. The solid phase extraction method was modified and validated for 15 organochlorine pesticides and the hyperspeed separation method was applied using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry. The limit of detection range was 0.38 and 17.96 ng mL-1 and limits of quantification were between 1.18 and 54.43 ng mL-1. Endosulfan lactone was detected in the Pirapetinga River (point 4 rainy season, 255 ng mL-1 and point 5 dry season, 142 ng mL-1), in addition to hexachlorocyclohexane (point 6 rainy season, 40.69 ng mL-1).
Strategic Approaches to the Construction of Energy-Efficient Housing in Russia
Authors: Nikonorov Sergey , Sardarly Aldun
Published: August 2023

The article examines the issues of strategic approaches to the construction of energy efficient buildings in the context of green building. International and Russian environmental standards are considered as a tool to improve the efficiency of green building. The purpose of the study is to identify the features of the current state of energy efficiency of buildings in Russia and to identify strategic development trends. Objectives – to study the regulatory framework that stimulates the strategic development of green building and energy efficiency; review of applied energy efficient technologies; review of national environmental standards.
THE RELATIONSHIP BETWEEN OCCUPATIONAL HEALTH AND SAFETY CULTURE AND LOW BACK PAIN, NECK PAIN AND WORK LIMITATIONS IN HEALTHCARE PROFESSIONALS
Authors: Özdemir Neşe , Alkan Halil
Published: August 2023

Purpose: This study was carried out to investigate the relationship between occupational health and safety culture, low back pain, neck pain and work limitations in healthcare professionals.
Methods: This descriptive cross-sectional study was conducted on 145 healthcare professionals working at Muş State Hospital between March 2022 and June 2022. The data was collected through Personal Information Form, Occupational Safety Culture Scale, Functional Low Back Pain Scale, Neck Bournemouth Questionnaire, and Work Limitations Questionnaire.
Results: While a statistically positive correlation was found between the occupational safety culture scores of health workers and functional activities due to the reduction low back pain, a statistically negative correlation was determined between the occupational safety culture scores and neck pain and work limitation (p