bluuebunny/crossref_metadata_2025 huggingface dataset:
Autoinflammatory diseases. Part 2. Pyrin inflammasomopathies and other enhanced interleukin 1 signaling syndromes
Authors: Shvaratska O.V. , Bordii T.A. , Hodiatska K.K. , Kalichevska M.V. , Klymenko O.V. , Taran O.M. , Klimova O.V. , Vilenskyi Ya.V.
Published: January 2025

Systemic autoinflammatory diseases (SAIDs) are considered dysregulation disorders of the innate immune system characterized by systemic sterile inflammation independent of infection and autoreactive antibodies or antigen-specific T cells. Autoinflammation is often mediated by inflammasomes; accordingly, inflammasomopathies and other enhanced interleukin (IL) 1 signaling syndromes represent a major classification group of SAIDs. Inflammasomes differ by the type of intracellular receptor which acts as a scaffold protein for the entire complex. Specifically, pyrin is one of the main intracellular sensor proteins that can initiate the formation of inflammasomes. This scientific review is the second in a series of publications jointly aiming to increase medical professionals’ awareness of SAIDs in children. It focuses on the current scientific understanding of pyrin inflammasomopathies which represent a significant cluster of all inflammasomopathies and other enhanced IL-1 signaling syndromes. We performed a focused search over the Web of Science, Scopus, PubMed Central®, Google Scholar databases over the past 10 years using the keywords “autoinflammatory diseases”, “autoinflammation”, “inflammasomopathies”, “pyrin”. The work presents an overview of inflammasomopathies, discusses the immunobiological features of the sensor protein pyrin and pyrin inflammasomes including cellular expression and molecular mechanisms of their activation and signal limitation. The review also presents the clinical and pathogenetic characteristics of the genetically determined pyrin inflammasomopathies and other enhanced IL-1 signaling syndromes: familial Mediterranean fever; pyrin-associated autoinflammation with neutrophilic dermatosis; mevalonate kinase deficiency; PSTPIP1-associated inflammatory diseases; periodic fever, immunodeficiency and thrombocytopenia syndrome; neonatal-onset cytopenia with dyshematopoiesis, autoinflammation, rash, and hemophagocytic lymphohistiocytosis; deficiency of IL-1 receptor antagonist; deficiency of IL-36 receptor antagonist; loss of IL-1 receptor to IL-1 receptor antagonist syndrome.
From a Smuggling Item to a Propaganda Tool: Historical Insights into the Circulation of Russian Imperial Currency in Mongolia, Nineteenth to Early Twentieth Centuries
Authors:   Institute  for Mongolian, Buddhist and Tibetan Studies, Siberian Branch of the RAS (6, Sakhyanova St., 670047 Ulan-Ude, Russian Federation), Plekhanova Anna M. , Shirapov Aldar A. ,   Institute  for Mongolian, Buddhist and Tibetan Studies, Siberian Branch of the RAS (6, Sakhyanova St., 670047 Ulan-Ude, Russian Federation), Dorzhiev Naidan-Zhargal B. ,   Institute  for Mongolian, Buddhist and Tibetan Studies, Siberian Branch of the RAS (6, Sakhyanova St., 670047 Ulan-Ude, Russian Federation)
Published: January 2025

Introduction. The article examines the circulation of Imperial Russia’s currency in Mongolia’s domestic markets during the nineteenth and early twentieth centuries. Goals. The study seeks to determine and analyze the role of Russian currency in Mongolia during the identified period. To facilitate this, the work shall investigate reasons behind the change in the Russian ruble’s status, determine the then functions performed by the latter abroad. Materials and methods. The study focuses on regulatory and legal documents aimed at administering state policy of the Russian Empire in the fields of money circulation and development of trade relations with Inner Asian countries, investigates related archival materials housed at the State Archive of Buryatia and that of Irkutsk Oblast. The key research methods employed include that of historical reconstruction, and chronological, statistical, systemic historical ones. These put together have made it possible to reconstruct how the status of Russian ruble in Mongolia’s financial market would change in the context of large-scale political and economic processes witnessed by nations of Inner Asia during the period in question. Results. The development of trade relations between Imperial Russia and Inner Asian nations entailed multiple changes in the status of Russian currency within Mongolia’s markets. Having been an illegal commodity in the early-to-mid nineteenth century, Russian ruble grew to become a recognized tool of mutual settlements at the turn of the twentieth century. The solid status that proceeded from S. Witte’s successful financial reform made it possible for the Russian currency to hold a firm place in the financial market of Mongolia, which it turn had most favorable impacts on Russia-Mongolia trade cooperation.
Investigating Kalmykia’s Governance Arrangements, Mid-to-Late Nineteenth Century: Documents of Horde [Affairs] Department at Astrakhan Chamber of State Property (1848–1867) as a Historical Source
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Mandzhikova Larisa B.
Published: January 2025

Introduction. The mid-to-late nineteenth century was witnessing further integration of Kalmyk Steppe and its society into the Russian state system. During the period under review, it was the Horde [Affairs] Department at Astrakhan Chamber of State Property (1848–1881) that became in charge of the administrative reform, with activities guided by the Kalmyk People’s Governance Regulations of 23 April 1847. The agency’s documents had compiled Collection И-6 (‘Horde [Affairs] Department at Astrakhan Chamber of State Property, 1832–1881’) at the National Archive of Kalmykia. Goals. The study seeks to investigate the reference apparatus to Collection И-6, analyze its structure and types of documents, identify common and distinctive features in record keeping at the newly created government body after the introduction of the 1847 Regulations, and the former’s source potential for historical research of state institutions in prerevolutionary Kalmykia. Results. The Regulations of 1847 established a clear division of powers between the Governor’s Office and Kalmyk elites, and sought to articulate certain division of powers in Kalmyk self-governance too. The Regulations specified directions of activity for structural units of the Horde [Affairs] Department, which had its impacts on workflow management essentials of the Kalmyk people’s governing body. The documents that resulted from the latter’s activities are related to official record keeping and their formatting patterns meet the requirements of that era. The archival documents included in Collection И-6 are a valuable source for further historical insights into how local public institutions in Russia would develop throughout the prerevolutionary period, and how Kalmykia’s administrative structures would evolutionize accordingly.
EVALUATION OF A LOW-COST-SENSOR-BASED PARTICULATE MATTER MONITOR: A COMPARATIVE STUDY
Authors: Božilov Aca
Published: January 2025

Indoor air quality (IAQ) significantly affects health, productivity, and comfort, particularly in urban environments, where individuals spend over 90% of their time indoors. Indoor air is often more polluted than outdoor air due to various indoor pollution sources. Effective IAQ monitoring is essential but often constrained by the high cost and complexity of traditional gravimetric methods and high-end automatic monitors. Emerging low-cost sensors offer an affordable and scalable alternative.This study examines the performance of the PM V1.0 device, equipped with a low-cost NOVA SDS011 particulate matter sensor (PM10 and PM2.5 fractions). The PM V1.0 was compared against two commercially available monitors: the high-precision Microdust PRO CEL-712 and the budget-friendly Dylos DC1100 PRO. Measurements conducted over 10 days through co-location of the monitors showed strong correlations between the PM V1.0 and the comparison devices, with coefficients of determination (R2) values exceeding 0.93 for both PM fractions.These findings validate the PM V1.0 as a reliable, cost-effective alternative for IAQ monitoring. The research highlights the potential of low-cost sensors to improve IAQ monitoring by providing affordable solutions.
Embarazo durante la adolescencia en México y en Morelos: algunos datos, evidencias y apuntes para la política pública de cara al nuevo sexenio
Authors: Sosa Sánchez Itzel A.
Published: January 2025

El embarazo durante la adolescencia es un fenómeno que ha despertado un amplio interés académico y político en las últimas décadas en México y otras latitudes. En este artículo se presentan de modo resumido los hallazgos de investigación sobre el tema y las reflexiones derivadas, poniendo énfasis en los contextos mexicano y morelense, con la finalidad de hacer algunas propuestas de política pública de cara al sexenio naciente.
Semiorganic Crystal Mixed Crystal Hexakis(Urea)Cobalt(II) Sulfate Monohydrate - Optical, Thermal and Mechanical
Authors: Nazeer Shaik Alla , Ramasamy G.
Published: January 2025

Abstract: Single crystals of hexakis(urea)cobalt(II) sulfate monohydrate have been grown by slow evaporation solution growth
technique at room temperature. The single crystal X-ray diffraction study reveals that the crystal belongs to orthorhombic system
with noncentrosymmetric space group Pca21 and the cell parameters are, a = 15.0549(6) A˚ , b = 7.2105(3) A˚ , c =
20.0284(9) A˚ , V = 2174.15 (16) A˚ 3 and Z = 4. The functional groups of the metal–urea complex were confirmed by
Fourier transform infrared spectroscopy. The powder X-ray diffraction study reveals the crystallinity of the as-grown material.
The band-gap energy of the specimen is estimated by Kubelka–Munk algorithm. The dielectric results indicate an increase in
dielectric and conductivity parameters with an increase of temperature at all frequencies. The crystal is further characterized by
mechanical and thermal analysis.
Growth, Characterization and Nonlinear Optical Activities of some Chalcones Derivatives
Authors: Nazeer Shaik Alla , Ramasamy G.
Published: January 2025

Abstract: The growth and characterization of NLO active chalcone derivatives, 1-(4-chlorophenyl)-3-(4-nitrophenyl)prop2-en-1-one (4CPNPC), 1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (4CPMPC) and 3-(3-chlorophenyl)-1-(4-
methoxyphenyl)prop-2-en-1-one (3CPMPC) are grown by slow evaporation solution growth technique from ethanolic solution at
room temperature. Single crystal XRD analysis reveals that 4CPNPC and 4CPMPC belong to the orthorhombic system with
noncentrosymmetric space group Pna21 whereas 3CPMPC crystallizes in monoclinic system with noncentrosymmetric space
group P21. The band gap energies of the specimens were estimated by the DRS data using Kubelka – Munk algorithm. Good
thermal stability up to the melting point is observed. SEM images reveal imperfections, voids and surface roughness. It is
interesting to observe that when Cl- and -OCH3 groups are in para- position enhanced SHG activity is observed because of facile
charge transfer. Theoretical calculations were performed to derive the optimized molecular structure, HOMO – LUMO diagram
and first-order molecular hyperpolarizability
Bike E-Catalogue with Web and App Compatibility for Bike Parameters Tracking
Authors: Vishwakarma Divyansh , Kumar Rajnish , Upadhyay Ayushi , Kumar Avinash , Mandal Monu Kumar , M Dr. ChandraSekhar
Published: January 2025

Abstract: This research presents a pioneering platform that revolutionizes the biking industry by seamlessly integrating digital
cataloguing with IoT-enabled real-time parameter tracking, accessible through web and mobile applications. By addressing
critical gaps in the current market, the platform delivers an innovative solution tailored to the evolving needs of bike enthusiasts
and owners. The system utilizes React and TypeScript to create an interactive and responsive front-end interface, ensuring crossplatform compatibility and an engaging user experience. On the back end, Java and Python power efficient data processing,
secure communication with IoT devices, and scalable server-side operations. Deployment through Netlify provides a robust and
reliable infrastructure with high availability and minimal downtime, while Figma-based designs ensure user-centric interfaces
that prioritize accessibility, personalization, and ease of navigation.
Key features include a dynamic e-catalogue, offering AR-enhanced bike exploration and comparison, and IoT-enabled tracking,
which provides real-time insights into bike parameters such as speed, mileage, and battery health. Advanced security features,
including GPS tracking and secure Bluetooth pairing, safeguard against theft, while cloud-based synchronization ensures
consistent user experiences across devices. This study delves into the technological advancements underpinning the platform,
including IoT integration, AR visualization, and modern web development practices. It highlights the platform’s potential to
transform bike ownership by streamlining the purchasing process, enhancing maintenance efficiency through predictive
insights, and promoting safety through advanced theft prevention mechanisms.
Furthermore, the research explores broader implications for the biking industry, such as fostering sustainability by encouraging
eco-friendly transportation and driving innovation through data-driven decision-making. Future development opportunities
include expanding IoT compatibility, incorporating AI-driven analytics for personalized recommendations, and integrating
blockchain-based security for data integrity and trust. By merging cutting-edge technology with user-focused design, this
platform establishes a new benchmark for smart biking solutions, promising convenience, safety, and sustainability for users
while setting a precedent for innovation in the biking industry
Effects of Combining Herbal Medicine with Western Medicine on Patients with Variant Angina Pectoris: Systemic Review and Meta-analysis (PRISMA Compliant)
Authors: Kwon Seong-eun , Jeon Hyeon-yeong , Kwon Jung-nam
Published: January 2025

Objective: The aim was to compare the effectiveness of traditional Korean herbal medicine versus conventional management in patients with variant angina.Methods: We searched several databases, including five international databases and five domestic electronic databases, for relevant studies. A search was conducted using keywords such as “Korean medicine”, “Chinese medicine”, and “variant angina pectoris” on February 28, 2024. Two review authors independently extracted the data. We assessed the risk of systemic errors by evaluating risk domains using the Cochrane risk of bias tool. When appropriate, meta-analyses were performed.Results: Twenty-nine trials were included in the review. For these reports, a meta-analysis was performed using RevMan 5.3. The meta-analysis showed that the treatment group (herbal medicine combined with Western medicine) had a significantly higher clinical effective rate and ECG effective rate than the control group (Western medicine only) (OR 4.56 95% CI 3.43 to 6.07, P<0.00001, I2=0%) (OR 3.20 95% CI 2.07 to 4.93, P<0.00001, I2=0%). The treatment group also showed a significantly reduced frequency and duration of angina (MD -1.77 95% CI -2.08 to -1.46, P=0.006, I2=50%) (MD -1.51 95% CI -2.24 to -0.78, P<0.00001, I2=0%).Conclusion: This systematic review and meta-analysis suggests that the combined treatment of herbal medicine and Western medicine can be effective in treating variant angina. However, the results might be somewhat biased because of the unknown or high risk of bias in the included trials and the insufficiency of subgroup studies. Therefore, further studies should consider a large number of high-quality clinical studies.
The Effect of Banhahubak-tang-gami on Thyroid Nodules: A Systematic Review and Meta-Analysis
Authors: Pak So-hyun , Bae Bo-ram , Jin Myung-ho
Published: January 2025

Objective: The purpose of this study was to investigate the effect of Banhahubak-tang-gami on thyroid nodules through a systematic review and meta-analysis of randomized controlled trials (RCTs).Methods: An online search was conducted using keywords such as “thyroid nodule”, “Banhahubak-tang”, ‘‘BanxiaHoupo Decoction”, and “Pinellia and Officinal Magnolia Bark Decoction” in 11 databases (Pubmed, Cochrane, Embase, ScienceDirect, CNKI, CiNii, RISS, KISS, ScienceON, OASIS, and DBpia) on August 1, 2024. There were no limits on the publication period and language. A meta-analysis was conducted by synthesizing the result data, such as total effective rate (TER), maximum thyroid nodule diameter, TSH, and TCM symptom score (TSS), using RevMan web. The quality of the studies was evaluated using Cochrane’s risk of bias (RoB).Results: Five RCTs met the inclusion criteria. The meta-analysis revealed that the treatment group (Banhahubak-tang-gami or Banhahubak-tang-gami with Western medicine) showed a more statistically significant effect compared to the control group (Western medicine or non-treatment) in TER (RR: 1.62, 95% CI 1.10~2.38, P=0.02), maximum thyroid nodule diameter (RR: -2.85, 95% CI -4.62~-1.07, P=0.002), TSH(RR: -0.15, 95% CI -0.24~-0.07, P=0.00004), TSS(RR: -2.75, 95% CI -3.41~-2.09, P=0.0005).Conclusion: This study suggests that Banhahubak-tang-gami can be effective for treating thyroid nodules. However, the included studies appear to be of low quality and involve only small sample sizes, suggesting that additional research is necessary.
A Review of Herbal Medicine for the Treatment of Chronic Fatigue Syndrome
Authors: Seo Min-jo , Kim Soo-duk , Park Su-na , Kim So-rim , Sun Jung-hum , Ha Dong-hyon , Kong Geon-sik , Choi Yo-sup
Published: January 2025

Objective: This study aimed to systematically review and analyze the effects of herbal medicine treatment on chronic fatigue syndrome (CFS) after COVID-19.Methods: CFS-related studies published from January 1, 2020 to August 31, 2024 were screened from databases. A total of 15 randomized controlled trials (RCTs) were selected. A meta-analysis was conducted based on outcome measurements, such as the total effective rate (TER). Cochrane’s risk of bias 2 (RoB 2) was used for the qualitative evaluation of the papers.Results: All the studies were conducted in Asia, with 80% from China. The CFS diagnoses were mostly based on the Centers for Disease Control and Prevention (CDC) 1994 guidelines. The most common TKM diagnosis after COVID-19 was spleen deficiency, and the most frequently used outcome measurement was the TER. A meta-analysis showed statistically significant improvements of herbal treatments compared to Western medicine and conventional herbal medicine treatment in most studies.Conclusion: After COVID-19, herbal medicine treatment for CFS has focused on spleen deficiency syndrome, considering viral infection-induced immune system dysfunction as the primary cause. Newly researched herbal medicines have shown significant therapeutic effects. However, as this study has some limitations, improvements in the quality of research are required.
In-pipe robot with automatic wheel span adjustment
Authors: Cerevka Tomas , Kelemen Michal
Published: January 2025

The wheeled in-pipe robot with automatic adjustment of the wheel span according to the diameter of the pipeline is intended for movement in pipelines. This robot includes a mechanism for adapting the width of the wheels according to the inner diameter of the pipe. The developed motion module can be used multiple times and thus realize a robot with a larger number of modules to achieve greater traction force.
Linear gate bounds against natural functions for position-verification
Authors: Asadi Vahid , Cleve Richard , Culf Eric , May Alex
Published: January 2025

A quantum position-verification scheme attempts to verify the spatial location of a prover. The prover is issued a challenge with quantum and classical inputs and must respond with appropriate timings. We consider two well-studied position-verification schemes known as f-routing and f-BB84. Both schemes require an honest prover to locally compute a classical function f of inputs of length n, and manipulate O(1) size quantum systems. We prove the number of quantum gates plus single qubit measurements needed to implement a function f is lower bounded linearly by the communication complexity of f in the simultaneous message passing model with shared entanglement. Taking f(x,y)=∑ixiyi to be the inner product function, we obtain a Ω(n) lower bound on quantum gates plus single qubit measurements. The scheme is feasible for a prover with linear classical resources and O(1) quantum resources, and secure against sub-linear quantum resources.
FRONTEIRA, GLOBALIZAÇÃO E AGROECOLOGIA NA FEIRA LIVRE DE LADÁRIO/MS, BRASIL
Authors: Augusto Souza da Rocha Elvis , Aparecido da Costa Edgar
Published: January 2025

A globalização, a agroecologia e o desenvolvimento sustentável são temas interconectados que estão em evidência na sociedade atual. Este artigo tem como objetivo comparar a quantidade de consumidores que frequentam e a variedade de produtos vendidos na maior banca do Grupo Bem-Estar, do assentamento 72, do município de Ladário/MS e na maior dos feirantes bolivianos na feira livre de sábado. Utilizou-se trabalho de campo, com a técnica da observação e contagem simples dos consumidores e das hortaliças comercializadas. Observou-se que a banca boliviana apresenta maior quantidade de consumidores e variedade de produtos comercializados.
A lightweight defect classification method for latex gloves based on image enhancement
Authors: Ren Yong , Liu Dong , Gu Sanhong
Published: January 2025

This paper presents a glove defect classification method that integrates
image enhancement techniques with a lightweight model to enhance the
efficiency and accuracy of glove defect classification in industrial
manufacturing. A dataset comprising images of five types of gloves was
collected, totaling 360 sample images, for the training and validation of a
deep learning-based glove defect classification model. Image enhancement
techniques, including super-pixels, exposure adjustment, blurring, and
limited contrast adaptive histogram equalization, increased dataset
diversity and size, improving model generalization. Based on the lightweight
model MobileNetV2, the model was improved by reducing the number of input
image channels through grayscale conversion and optimizing the loss
function. Experimental results demonstrate that the improved MobileNetV2
model achieved an average accuracy of 97.85% on both the original and
enhanced datasets, effectively mitigated overfitting phenomena, and
exhibited a significantly faster training speed compared to the ResNet34 and
ResNet50 models.
Real exchange rate, wage-led policies, and demand growth in Brazil: A regime switching and time sensitive study
Authors: Iasco Pereira Hugo , Costa Santos Júlio
Published: January 2025

The aim of this article is twofold. First, we discuss stylized facts about
the Brazilian economy related to the redistribution of income to labor, and
the appreciation of the real exchange rate, examining their influence on
demand growth. Second, the article empirically investigates the influence
that both increasing real wages and depreciating the real exchange rate had
on the short-term performance of Brazilian manufacturing between 2002 and
2020. To this end, a set of time series regressions is estimated using two
methods. Markov-switching model estimates provide some evidence that
reducing the real wage, or appreciating the national currency, had some
positive influence on growth in industrial demand during normal periods,
however, this did not apply during periods of crisis. On the other hand,
wavelet estimates suggest that, between 2002 and 2005, a growth strategy
based on increasing the real minimum wage was a coherent policy for boosting
short-term industrial demand.
A new model of experimental diabetic cardiomyopathy using combination of multiple doses of anomer-equilibrated streptozotocin and high fat diet: sex matters.
Authors: Karatzia Loucia , Cullen Fenn , Young Megan , Lam Shing Hei , Morales Valle , Bianchi Katiuscia , Henson Sian M. , Aksentijevic Dunja
Published: January 2025

Diabetes mellitus (DM) leads to a more rapid development of DM cardiomyopathy (dbCM) and progression to heart failure in women than men. Combination of high-fat diet (HFD) and freshly-injected streptozotocin (STZ) has been widely used for DM induction, however emerging data shows that anomer-equilibrated STZ produces an early onset and robust DM model. We designed a novel protocol utilising a combination of multiple doses of anomer-equilibrated STZ injections and HFD to develop a stable murine DM model featuring dbCM analogous to humans. Furthermore, we examined the impact of biological sex on the evolution of cardiometabolic dysfunction in DM. Our study included six experimental protocols (8 weeks) in male and female C57BL/6J mice (n=109): Fresh STZ+HFD, Anomer-equilibrated STZ+HFD, HFD, Fresh STZ, Anomer-equilibrated STZ, Control diet+vehicle. Animals were characterised by extensive phenotyping in vivo and ex vivo. Anomer-equilibrated STZ+HFD led to induction of stable experimental murine DM characterised by impaired glucose homeostasis, cardiometabolic dysfunction and altered metabolome of liver, skeletal muscle, kidney and plasma. dbCM was more severe in female mice including systolic dysfunction and reduced cardiac energy reserve. This study established a novel, robust model of inducible murine DM and emphasised the impact of biological sex on DM progression and severity.
A new model of experimental diabetic cardiomyopathy using combination of multiple doses of anomer-equilibrated streptozotocin and high fat diet: sex matters.
Authors: Karatzia Loucia , Cullen Fenn , Young Megan , Hei Lam Shing , Morales Valle , Bianchi Katiuscia , M. Henson Sian , Aksentijevic Dunja
Published: January 2025

Diabetes mellitus (DM) leads to a more rapid development of DM cardiomyopathy (dbCM) and progression to heart failure in women than men. Combination of high-fat diet (HFD) and freshly-injected streptozotocin (STZ) has been widely used for DM induction, however emerging data shows that anomer-equilibrated STZ produces an early onset and robust DM model. We designed a novel protocol utilising a combination of multiple doses of anomer-equilibrated STZ injections and HFD to develop a stable murine DM model featuring dbCM analogous to humans. Furthermore, we examined the impact of biological sex on the evolution of cardiometabolic dysfunction in DM. Our study included six experimental protocols (8 weeks) in male and female C57BL/6J mice (n=109): Fresh STZ+HFD, Anomer-equilibrated STZ+HFD, HFD, Fresh STZ, Anomer-equilibrated STZ, Control diet+vehicle. Animals were characterised by extensive phenotyping in vivo and ex vivo. Anomer-equilibrated STZ+HFD led to induction of stable experimental murine DM characterised by impaired glucose homeostasis, cardiometabolic dysfunction and altered metabolome of liver, skeletal muscle, kidney and plasma. dbCM was more severe in female mice including systolic dysfunction and reduced cardiac energy reserve. This study established a novel, robust model of inducible murine DM and emphasised the impact of biological sex on DM progression and severity.
Study the effect of low-level laser therapy on osteogenic capacity of periodontal ligament stem cell: An in vitro study
Authors: Salmani Zahra , Saberi Sogol , Hodjat Mahshid , Tavakoli Mahdi , Eslaminia Mahdi , Sanchooli Setare
Published: January 2025

The osteoblastic differentiation of periodontal ligament stem cells (PDLSCs) under laboratory conditions. The impact of a 915 nm diode laser at doses of 1.4, 2, 3.1, and 4 J/cm2, with irradiation time of 5, 7, 11, and 14 s, was assessed on osteogenic differentiation of PDLSCs by evaluating alkaline phosphatase activity, calcium deposition assessed by alizarin red-S staining, and the gene expression of Osteopontin and Osteocalcin by real-time polymerase chain reactions. The cells exposed to irradiation exhibited peak levels of alkaline phosphatase activity, along with increased gene expression of Osteopontin and Osteocalcin, particularly at a dose of 4 J/cm2. Also, the highest intensity of alizarin red staining was observed at doses of 3.1 and 4 J/cm2 as analysis using analysis of variance (ANOVA) (P < 0.05). The utilization of alow-level 915 nm diode laser at 4 J/cm2 has the potential to modulate the osteogenic differentiation of PDLSCs by enhancing the expression of osteogenic markers suggesting the potential clinical application of photobiomodulation. These findings indicate potential therapeutic applications in promoting bone regeneration, accelerating healing in periodontal and dental implant procedures, and treating bone-related defects in clinical practice.
Pengembangan Media Pembelajaran Matematika Berbantuan Google Sites pada Materi Sistem Persamaan Linear Dua Variabel
Authors: Arnisya Melinda Fahriani , Luritawaty Irena Puji , Sumartini Tina Sri
Published: January 2025

It is important to continue developing digital mathematics learning media. This research was conducted to develop learning media assisted by Google Sites on the material Systems of Linear Equations in Two Variables and to analyze the feasibility of this learning media. This research is descriptive research with the research and development method of the ADDIE model which consists of 5 stages, namely analysis, design, development, implementation and evaluation. The subjects for this learning media trial were 39 students in class VIII of one of the private junior high schools in Garut Regency. Based on the research results, this media meets the criteria for validity and practicality as a learning media product. This is known from: (1) the validity of learning media, which is based on the results of an assessment of the validity of the media and material, showing valid results with revision, with a material achievement percentage of 92.7% and a media achievement percentage of 83.3%; (2) the practicality of learning media, as assessed from the student response questionnaire, obtained a percentage of 74.25%, indicating results that fall into the practical category.
Neuroethics in medicine. Pressing issues
Authors: Filatova YS , Zolotova IA
Published: January 2025

The article focuses on some aspects of neuroethics in medicine. Due to the continuous growth of research, new advances in neuroscience, and use of neurotechnology, ethical issues related to personality, autonomy and confidentiality may arise. The article addresses neuroethical issues of management of patients with various neurological diseases and special psychological conditions. The issue of using neuroethical aspects to solve issues in the field of diagnosis and treatment of disorders of consciousness is also discussed. Another important area of research that uses neuroethics is treatment of drug addiction, namely the ethical aspects of using neurotechnology. The authors conclude that the prospects for using neuroethics in medicine are very diverse. It underlines the importance of its studying at all stages of medical education, including secondary, higher and postgraduate ones.
Capability Process to Optimize Specification by Impact of Wavelet Analysis
Authors: Qader Hogr M. , Birdawod Hawkar Q. , Qader Hevi M. , Sedeeq Bekhal S.
Published: January 2025

This study investigates the impact of wavelet analysis on optimizing specification in the capability process. A new approach called the New Hybrid Capability Wavelet Approach (NHCWA) is proposed, which utilizes wavelet analysis to filter noise and outliers in the data. The study compares the NHCWA with the classical capability process using a dataset from a cake factory. The Coiflet 4 wavelet family and soft thresholding are employed to denoise the data. The results demonstrate that the NHCWA significantly improves the capability indices, achieving a 50% increase in Cp and a 30% increase in Cpk compared to the classical approach. Additionally, the NHCWA reduces the standard deviation of the process by 20%. These findings highlight the potential of wavelet analysis in enhancing the accuracy and effectiveness of capability analysis, leading to improved quality control in manufacturing processes.
Social networks analysis of anticorruption messages on Twitter
Authors: Syaputra Hendry , Abdullah Aceng , Sjafirah Nuryah Asri
Published: January 2025

Corruption poses a serious threat to a nation’s progress and undermines public trust in the government. Therefore, it is often referred to as an extraordinary crime. Despite numerous measures being taken, it cannot be denied that corruption still occurs frequently. Thus, in addition to focusing on combating corruption, new approaches are important for disseminating anticorruption messages through various media, including social media. This study examines communication patterns, social network structures, key actors, and their roles in anticorruption messages on Twitter using Social Network Analysis (SNA) methods. Data collection techniques involve text mining or web crawling based on keywords using Gephi 0.97. The data was collected in December 2022, coinciding with the celebration of International Anticorruption Day (Hakordia). The results indicate that analysis units such as density, diameter, average path length, components, and modularity suggest that communication between actors in the network tends to be one-way, with some nodes serving as key actors. Interactions among Twitter users are minimal, with little or almost no reciprocal communication. Based on the patterns observed from the network of anticorruption messages and campaigns, the study reveals an asymmetrical communication network. In terms of actor centrality statistics, those with the highest centrality values are @kpk_ri, @democrazymedia, @tvonenews, @cnnindonesia, and @nazaqistsha. Each of these five actors plays a specific role in the network, depending on their backgrounds. This study concludes that in addition to government actors, mass media and even individuals play a crucial role in disseminating and campaigning for anticorruption messages.
Sustainable and equal integration of genomics into healthcare
Authors: Nogel Mónika
Published: January 2025

Technological advancements in genetic research are crucial for nations aiming to uplift their population’s quality of life and ensure a sustainable economy. Genomic information and biotechnology can enhance healthcare quality, outcomes, and affordability. The “P4 medicine approach”—predictive, preventive, personalized, and participatory—aligns with objectives like promoting long-term well-being, optimizing resources, and reducing environmental impacts, all vital for sustainable healthcare. This paper highlights the importance of adopting the P4 approach extensively. It emphasizes the need to enhance healthcare operations in real-time and integrate cutting-edge genomic technologies. Eco-friendly designs can significantly reduce the environmental impact of healthcare. Additionally, addressing health disparities is crucial for successful healthcare reforms.
Demystifying artificial intelligence for veterinary professionals: practical applications and future potential
Authors: Sobkowich K. E.
Published: January 2025

The field of veterinary medicine, like many others, is expected to undergo a significant transformation due to artificial intelligence (AI), although the full extent remains unclear. Artificial intelligence is already becoming prominent throughout daily life (eg, recommending movies, completing text messages, predicting traffic), yet many people do not realize they interact with it regularly. Despite its prevalence, opinions on AI in veterinary medicine range from skepticism to optimism to indifference. However, we are living through a key moment that calls for a balanced perspective, as the way we choose to address AI now will shape the future of the field. Future generations may view us as either overly optimistic, blinded by AI's allure, or overly pessimistic, failing to recognize its potential. By understanding how algorithms function and predictions are made, we can begin to demystify AI, seeing it not as an all-knowing entity but as a powerful tool that will assist veterinary professionals in providing high-level care and progressing in the field. Building awareness allows us to appreciate its strengths and limitations and recognize the ethical dilemmas that may arise. This review aims to provide an accessible overview of the status of AI in veterinary medicine. This review is not intended to be an exhaustive account of AI.
Peering into the Heart: A Comprehensive Exploration of Semantic Segmentation and Explainable AI on the MnMs-2 Cardiac MRI Dataset
Authors: Ayoob Mohamed , Nettasinghe Oshan , Sylvester Vithushan , Bowala Helmini , Mohideen Hamdaan
Published: January 2025

Accurate and interpretable segmentation of medical images is crucial for computer-aided diagnosis and image-guided interventions. This study explores the integration of semantic segmentation and explainable AI techniques on the MnMs-2 Cardiac MRI dataset. We propose a segmentation model that achieves competitive dice scores (nearly 90 %) and Hausdorff distance (less than 70), demonstrating its effectiveness for cardiac MRI analysis. Furthermore, we leverage Grad-CAM, and Feature Ablation, explainable AI techniques, to visualise the regions of interest guiding the model predictions for a target class. This integration enhances interpretability, allowing us to gain insights into the model decision-making process and build trust in its predictions.
ASSESSMENT OF THE LEVEL OF INACTIVATION OF OPISTHORCHIS FELINEUS METACERCARIAE IN FISH TISSUES THE CYPRINIDAE FAMILY FOR THE PRODUCTION OF NEW PRODUCTS IN KHANTY-MANSIYSK AUTONOMOUS OKRUG – YUGRA
Authors:   Khanty-Mansiysk State Medical Academy, Nekhorosheva Alexandra Viktorovna , Nekhoroshev Sergey Viktorovich , Karpova Yana Alexandrovna , Yanin Vladimir Leonidovich , Ibraev Zhaksylyk Turanovich , Zaikina Julia Gennadievna , Sazonova Natalia Alexandrovna , Bondarenko Oksana Mikhailovna , Biktimirov Timur Rafaelievich , Nekhorosheva Daria Sergeevna , Tagirova Aishat Sakhrudinovna , Nesterov Danil Ivanovich
Published: January 2025

in an experiment on laboratory animals – Syrian hamsters Mesocricetus auratus, the inactivation of metacercariae of Opisthorchis felineus in the tissues of fish of the Cyprinid family was evaluated. Objective data confirming the effectiveness of the proposed method have been obtained.
THE RESULTS OF THE WORK OF THE RESEARCH INSTITUTE OF MICROSURGERY (TOMSK)
Authors:   Privolzhsky District Medical Center, Yarikov Anton Viktorovich ,   National Research Nizhny Novgorod State University named after N.I. Lobachevsky,   City Clinical Hospital No. 39, Butrimova Svetlana Viktorovna ,   Privolzhsky District Medical Center, Baitinger Andrey Vladimirovich ,   Research Institute of Microsurgery,   Krasnoyarsk State Medical University named after V.F. Voino-Yasenetsky,   Siberian State Medical University, Baitinger Vladimir Frantsevich , Selyaninov Konstantin Vladimirovich , Fraerman Alexander Petrovich ,   City Clinical Hospital No. 39, Perlmutter Olga Alexandrovna , Tsybusov Sergey Nikolaevich ,   National Research Nizhny Novgorod State University named after N.I. Lobachevsky, Mukhin Alexey Stanislavovich
Published: January 2025

The article presents the results of medical, scientific and publishing activities, as well as the results of research at the Institute of Microsurgery in Tomsk. The relevance and importance of microsurgery in the practical activities of a number of medical specialties is shown, and the Institute of Microsurgery is now rightfully considered one of the leading centers of microsurgery. The huge educational program of the center's professional development with the introduction of innovative technologies, which are so important for the continuing education of doctors, is shown.
SEASONAL ASPECTS OF THE USE OF SPECIALIZED FOOD PRODUCTS, AS A WAY TO INCREASE THE EFFECTIVENESS OF MEDICAL AND BIOLOGICAL SUPPORT FOR ATHLETES OF UGRA
Authors:   Khanty-Mansiysk State Medical Academy, Koinosov Andrey Petrovich , Gubina Anastasia Evgenievna , Sadrieva Elena Valerievna , Stepanov Aleksey Sergeevich ,   Yugra Boarding School of the Olympic Reserve, Rutkovsky Alexey Vladimirovich ,   Мoscow scientific and practical center of medical rehabilitation of rehabilitation and sports medicine named after S.I. Spasokukotsky
Published: January 2025

The article presents the results of a study of seasonal changes in metabolism in highly qualified athletes in cross-country skiing and biathlon. Based on the identified changes, the use of specialized and functional food products is proposed to improve the effectiveness of medical and biological support for athletes of the Khanty-Mansiysk Autonomous Okrug-Yugra, which will undoubtedly affect athletic performance.
The dwelling of the Yudinsky culture from the Russian settlement 1
Authors: Adamov Aleksandr Aleksandrovich , Turova Natalya
Published: January 2025

The object of the study is the excavation of residential building No. 4 of the Yudinsk archaeological culture, studied during archaeological work at the Russian settlement 1. The monument is located in the Yarkovsky district of the Tyumen region, on the right bank of the Tobol River, near the mouth of the Tura River. The purpose of the study is to introduce into scientific circulation and to examine in detail the unique materials from the Russian 1 settlement, represented by the excavation of a residential building at No. 4, to determine the type of dwelling, and to reconstruct the possible appearance of the lost structural elements of the structure. Based on the purpose of the study, the following tasks were put forward: a morphological description of the recorded elements of the archeologized structure No. 4, the determination of the time of the functioning of the settlement, as well as the reconstruction of the exterior of the frame of the dwelling based on available ethnographic materials. Traditional research methods for historical science are used to solve the tasks set in the work: comparative historical, typological, descriptive method of analysis of material sources, method of analogies. For the first time, based on a detailed comprehensive planographic analysis of the traces of the archeologized building No. 4, as well as their comparison with residential structures that existed among the aboriginal population of Siberia, it was established that the building from the Yudinsky settlement of Russian 1 was a semi-earthen building with a truncated pyramid-shaped frame. The construction of the ground part of the house is described, as well as details of the internal structure. The walls and roof were built from thin planks or scaffolds, which were then covered with a layer of earth thrown out of the excavation. A narrow corridor-shaped entrance led to the dwelling, above which a canopy was erected. The main open hearth was located in the center of the dwelling, and bunks with another hearth were located at the back wall. As a result of the conducted research, it was established that the monument existed in the period of the 8th–10th centuries.
Experiencia con comunidades del Pacífico colombiano inmersas en el conflicto armado
Authors: Cetina Matallana Kelly Tatiana , Rivera Caballero Carlos Julio , Rodríguez Sotelo Paula Andrea
Published: January 2025

Esta investigación es una construcción conjunta de conocimiento con comunidades del Pacífico colombiano, invisibilizadas históricamente por la matriz moderna occidental y que tienen saberes y experiencias en ocupaciones colectivas, concepto emergente en Colombia. Se desarrolló un proceso de investigación acción participativa con cuatro colectivos de Quibdó, en el departamento del Chocó, y de los caseríos de Vidrí y Vegaez, en límites entre los departamentos de Antioquia y Chocó, con el fin de dinamizar aproximaciones teóricas y vivenciales para acercarse a una comprensión de las ocupaciones colectivas, vistas como un insumo para la paz. La propuesta de comprensión se estructura alrededor de cuatro categorías emergentes: sentido de dignidad y resistencia, cultura, territorio, ideología y hacer cooperativo. Las ocupaciones colectivas son un proceso que se vive y se dinamiza de forma particular en cada comunidad, pueden surgir de múltiples posibilidades y aportan a la transformación social y a la construcción de paz desde la cotidianidad.
Prácticas adultistas en la crianza y participación ocupacional de las niñeces en el hogar
Authors: Poblete Almendras María José , Brito Olivares Valeria , Chandía Silva Catalina , Muñoz Riquelme Camila , Serrano Robles Javiera
Published: January 2025

El objetivo del artículo es tensionar las prácticas adultistas en la crianza y su relación con la participación en la niñez. El concepto de niñez es una construcción social, política y cultural que ha evolucionado con la historia. Tradicionalmente se ha visto como etapa preparatoria para la vida adulta, reflejando ideas de inferioridad y escaso valor social. En el hogar, las prácticas adultistas limitan la participación y la autonomía. Estas prácticas, que reflejan una visión adultocéntrica del mundo, pueden manifestarse de diversas formas, como la sobreprotección o la discriminación generacional. Para promover la participación de niños y niñas en el hogar, es necesario fomentar experiencias que les permitan desarrollar habilidades de decisión, autonomía y participación activa; sin embargo, en el contexto actual, estas oportunidades pueden ser limitadas. La participación de niñas y niños en el hogar y en la sociedad depende de la capacidad de las personas adultas para reconocer y respetar sus derechos, permitiéndoles desarrollar su agencia; esto requiere un cambio en las prácticas adultistas y una mayor conciencia sobre la importancia de involucrarles en la cotidianidad del hogar.
agremiación de la Terapia Ocupacional colombiana
Authors: Cruz Perdomo Jaqueline
Published: January 2025

Este editorial recoge la agremiación: en lo internacional, la cosecha; en lo nacional, la siembra y el abono. El 2025 brinda una nueva oportunidad para retomar los talentos de cada terapeuta ocupacional y entretejerlos comunitariamente, fortaleciendo así los saberes y las prácticas de la Terapia Ocupacional a nivel nacional y mundial. Se reconoce el trabajo de representación a nivel internacional, a través de dos miembros del Colegio Colombiano de Terapia Ocupacional, a partir del reciente cierre de sus períodos en las directivas de la Federación Mundial de Terapeutas Ocupacionales y la Confederación Latinoamericana de Terapeutas Ocupacionales. Se presentan además algunas proyecciones y perspectivas de trabajo del Colegio Colombiano de Terapia Ocupacional para el año 2025, particularmente, el XVII Congreso Colombiano de Terapia Ocupacional y el proyecto de modificación de la Ley de Terapia Ocupacional.
ECHOES OF THE PAST: ELDERLY CARE AND INSTITUTIONS IN LATE 19TH AND EARLY 20TH CENTURY OSIJEK
Authors: Lachner Višnja , Žiha Nikol , Brozović Elena
Published: January 2025

In the late nineteenth and early twentieth centuries, elderly care in Croatia predominantly relied on familial support, resulting in a lack of official data on their well-being. However, recognizing the gradual decrease of familial care during this period, the Town of Osijek instituted a formal social care system for the elderly. This study delves into the essential aspects of this system, focusing on the Town Poorhouse and its pivotal role in elderly care.

Drawing from primary sources in the State Archives of Osijek and limited relevant literature, the research aims to amplify the voices of elderly individuals from that historical era. It also sheds light on the involvement of Osijek’s town government and established foundations in the financing of elderly care initiatives during the late nineteenth century. The overarching objective is to widen the knowledge on unexplored historical facts and documents related to social welfare in Croatia by scrutinizing formal elderly care structures, as evidenced in previously untapped archival materials.