bluuebunny/crossref_metadata_2025 huggingface dataset:
Baseline IgG-Fc N-glycosylation profile is associated with long-term outcome in a cohort of early inflammatory arthritis patients
Authors: Sénard Thomas , Flouri Irini , Vučković Frano , Papadaki Garyfalia , Goutakoli Panagiota , Banos Aggelos , Pučić-Baković Maja , Pezer Marija , Bertsias George , Lauc Gordan , Sidiropoulos Prodromos
Published: August 2022

Background

Rheumatoid arthritis (RA) is a chronic autoimmune disease for which prediction of long-term prognosis from disease’s outset is not clinically feasible. The importance of immunoglobulin G (IgG) and its Fc N-glycosylation in inflammation is well-known and studies described its relevance for several autoimmune diseases, including RA. Herein we assessed the association between IgG N-glycoforms and disease prognosis at 2 years in an early inflammatory arthritis cohort.

Methods

Sera from 118 patients with early inflammatory arthritis naïve to treatment sampled at baseline were used to obtain IgG Fc glycopeptides, which were then analyzed in a subclass-specific manner by liquid chromatography coupled to mass spectrometry (LC-MS). Patients were prospectively followed and a favorable prognosis at 2 years was assessed by a combined index as remission or low disease activity (DAS28 < 3.2) and normal functionality (HAQ ≤ 0.25) while on treatment with conventional synthetic DMARDs and never used biologic DMARDs.

Results

We observed a significant association between high levels of IgG2/3 Fc galactosylation (effect 0.627 and adjusted p value 0.036 for the fully galactosylated glycoform H5N4F1; effect −0.551 and adjusted p value 0.04963 for the agalactosylated H3N4F1) and favorable outcome after 2 years of treatment. The inclusion of IgG glycoprofiling in a multivariate analysis to predict the outcome (with HAQ, DAS28, RF, and ACPA included in the model) did not improve the prognostic performance of the model.

Conclusion

Pending confirmation of these findings in larger cohorts, IgG glycosylation levels could be used as a prognostic marker in early arthritis, to overcome the limitations of the current prognostic tools.
An unusual presentation of anaphylaxis with severe hypertension: a case report
Authors: Govindapala Dumitha , Senarath Uththara Sachinthanie , Wijewardena Dasun , Nakkawita Dilini , Undugodage Chandimani
Published: August 2022

Background

Low blood pressure and associated postural symptoms are well-recognized manifestations of anaphylaxis. Nonetheless, anaphylaxis can present with high blood pressure and is rarely reported in the literature. We report an unusual presentation of anaphylaxis with severe supine hypertension and orthostatic intolerance.

Case presentation

A 43-year-old Asian female presented to the emergency department with generalized itching, hives, and postural dizziness after taking a slow-release diclofenac sodium 100 mg tablet. On admission, the patient was tachycardic with a supine blood pressure of 200/100 mmHg. She had urticaria and bilateral rhonchi. A clinical diagnosis of anaphylaxis was made. She was treated with intravenous hydrocortisone and chlorpheniramine, but intramuscular adrenaline was withheld owing to her high blood pressure. She was kept in the supine position, and her vital parameters were closely monitored. Although the respiratory and cutaneous symptoms improved with treatment, her blood pressure remained elevated. Forty minutes later, the postural dizziness recurred as she sat up on the bed and her blood pressure plummeted from 198/100 mmHg to 80/60 mmHg. She was put back in the supine position immediately, and the blood pressure was restored with three doses of intramuscular adrenaline and a fluid bolus. Her postural symptoms completely resolved after adrenaline, but her blood pressure remained elevated. Two weeks after the initial presentation, a diagnosis of essential hypertension was made, which probably had been undetected. In anaphylaxis, where the cardiovascular system is involved, a blood pressure reduction from baseline is expected in patients with preexisting hypertension. Despite cardiovascular involvement, our patients’ blood pressure on presentation to the emergency department was much higher than her pretreatment ambulatory blood pressure, thus making this presentation unusual.

Conclusions

Diagnosis and treatment of anaphylaxis can be delayed in patients presenting with high blood pressure. Postural symptoms should alert the clinician to cardiovascular involvement despite elevated supine blood pressure. Early treatment with adrenaline should be considered in these patients with extreme caution.
Graph convergence with an application for system of variational inclusions and fixed-point problems
Authors: Balooee Javad , Yao Jen-Chih
Published: August 2022

This paper aims at proposing an iterative algorithm for finding an element in the intersection of the solutions set of a system of variational inclusions and the fixed-points set of a total uniformlyL-Lipschitzian mapping. Applying the concepts of graph convergence and the resolvent operator associated with anĤ-accretive mapping, a new equivalence relationship between graph convergence and resolvent-operator convergence of a sequence ofĤ-accretive mappings is established. As an application of the obtained equivalence relationship, the strong convergence of the sequence generated by our proposed iterative algorithm to a common point of the above two sets is proved under some suitable hypotheses imposed on the parameters and mappings. At the same time, the notion of$H(\cdot,\cdot)$H(⋅,⋅)-accretive mapping that appeared in the literature, where$H(\cdot,\cdot)$H(⋅,⋅)is anα,β-generalized accretive mapping, is also investigated and analyzed. We show that the notions$H(\cdot,\cdot)$H(⋅,⋅)-accretive andĤ-accretive operators are actually the same, and point out some comments on the results concerning them that are available in the literature.
The spatial and temporal exploitation of anthropogenic food sources by common ravens (Corvus corax) in the Alps
Authors: Jain Varalika , Bugnyar Thomas , Cunningham Susan J. , Gallego-Abenza Mario , Loretto Matthias-Claudio , Sumasgutner Petra
Published: August 2022

Background

Anthropogenic food sources (AFSs) are widespread in human-transformed landscapes and the current scale at which they occur drives ecological change at the individual, population, and community levels. AFSs are exploited extensively by common ravens, Corvus corax. Understanding how raven populations use AFSs can provide insight into their ecological responses to AFSs.

Methods

We equipped 81 ravens in the Austrian Alps with GPS-transmitters over a period of 2.75 years. Using these tracking data, we investigated how cohort differences (i.e., age, sex, and origin) and seasonal changes influence raven movement patterns (i.e., occurrence distribution and maximum daily displacement) and AFS-use (i.e., number of AFSs visited and probability of being present at any AFS) at 45 extensively exploited sites.

Results

We found that proxies for experience and dominance, inferred by age (i.e., juvenile versus adult) and origin (i.e., wild-caught versus captive-bred-released) cohorts, influenced movement patterns and the number of AFSs visited. However, all individuals were equally likely to be present at AFSs, highlighting the importance of AFSs for non-breeders in the study population. Seasonal changes in environmental conditions that affect energetic demands, the availability of natural and anthropogenic food, and foraging competition,  influenced individuals’ occurrence distributions and AFS-use. We found that under harsher conditions in autumn and winter, individuals ranged wider and depended on AFSs to a larger degree. However, contrary to expectation, they were less likely to be present at AFSs in these seasons compared to spring and summer, suggesting a trade-off between time spent moving and exploiting resources. We attribute the small ranging movements exhibited by non-breeders in spring and summer to the presence of highly territorial and socially dominant breeders. As breeders mostly stay and forage within their territories during these seasons, competition at AFSs decrease, thereby increasing the likelihood of individuals being present at any AFS.

Conclusions

We emphasize that movement and AFS-use differ according to cohort differences and the seasonality of the environment. Our results highlight that predictable AFSs affect foraging strategies among non-breeding ravens. The extent of AFS-exploitation among non-breeding ravens in our study emphasize the potential of AFSs in shaping raven movement and resource-use.
Musculoskeletal injuries sustained at the California, USA: Baja California, Mexico border
Authors: Dwight Kathryn D. , Kent William T. , Hughes-Austin Jan M.
Published: August 2022

Background

Individuals attempting to enter the USA from Mexico at non-authorized points along the border fence often sustain injuries requiring medical intervention. We evaluated characteristics of this patient population and their hospital care to better understand patient treatment needs. Given the high-velocity nature of these injuries, we hypothesized that higher pain scores would be associated with longer lengths of hospital stay.

Methods

In this cross-sectional study, we selected records of all patients from 2013 to 2019 who received care by the Orthopaedic Surgery department following an injury sustained at the California-Baja California border. We evaluated demographics, musculoskeletal injuries, procedures, length of hospital stay (LOS), follow-up, and pain scores via retrospective chart review. We used linear regression, adjusting for age and gender, to evaluate associations between pain scores and hospital LOS.

Results

Among all 168 patients, there were 248 total injuries comprised of 46% lower extremity, 15% upper extremity, 17% spine, and 4% pelvic injuries. Average age at injury was 33 ± 10, 74% were male, and 85% identified as Hispanic. Of this patient population, 68% underwent operative interventions, 26% sustained open injuries, and 21% required external fixation for initial injury stabilization. Thirteen percent were seen for follow-up after discharge. Spine (n = 42), pilon (n = 36), and calcaneus fractures (n = 25) were the three most common injury types. Average LOS for all patients was 7.8 ± 8.1 days. Pain scores were not significantly associated with LOS ( p =  0.08). However, for every surgical procedure performed, hospital LOS was increased by 5.16 ± 0.47 days (p < 0.001).

Conclusion

Many injuries incurred by patients crossing the border were severe, requiring multiple surgical interventions and a prolonged LOS. The higher number of procedures was significantly associated with longer LOS in all operatively treated patients. Future studies are needed to determine how we can optimize care for this unique patient population and facilitate post-discharge care.
Level and predictors of mental health literacy of depression and suicide among undergraduate medical students
Authors: Abdelsalam Noha M. , Said Randa M.
Published: August 2022

Background

Poor mental health literacy (MHL) is considered a significant barrier to medical students seeking treatment for depression and suicide. This study aimed to assess the level of mental health literacy of depression and suicide among undergraduate medical students as well as to determine its predictors. An online survey was conducted on 361 undergraduate medical students through the Microsoft Team platform using a Google form application-structured questionnaire that included a sociodemographic section, the depression literacy scale (D-Lit), and the modified suicide literacy scale (LOSS).

Results

The mean D-Lit score was 7.9 ± 1.8 (total score ranged from 0 to 22), while the mean LOSS score was 4.5 ± 1.7 (total score ranged from 0 to 12). Only 36.8% of students had depression literacy levels higher than the mean depression score, whereas 28.8% had a suicide literacy level exceeding the mean suicide score. A statistically significant positive correlation was revealed between the mean score of depression literacy and that of suicide literacy (r= 0.16,p-value = 0.002). Male gender (p< 0.05), family history of depression (p< 0.05), and history of suicidal ideations (p< 0.01) are all predictors of higher depression literacy scores.

Conclusions

According to the results, there is compelling evidence that depression and suicide literacy among medical students was low. Therefore, rather than waiting until a medical student reaches the clinical years, mental health education should be introduced early in medical school curricula or even in high school.
The relevance of chest X-ray radiologic severity index and CURB-65 score with the death event in hospitalized patient with COVID-19 pneumonia
Authors: Prasetyo Nicolaus Erlangga , Satoto Bambang , Handoyo Thomas
Published: August 2022

Background

The global pandemic respiratory infection COVID-19 has had a high mortality rate since early 2020 with a broad spectrum of symptoms and giving a high burden. This study used the chest X-ray radiologic severity index method to radiologically assess the degree of lung lesions and the CURB-65 score to clinically assess COVID-19 pneumonia patients associated with the incidence of death in hospitalized patients.

Results

The research data were carried out from March 2020 to April 2021 based on patient medical records and chest X-rays at Doctor Kariadi General Hospital Semarang Indonesia. One hundred and five subjects were collected that fulfilled the inclusion and exclusion criteria. The CURB-65 score ≥ 2 had a significant relationship to the death event with a prevalence interval of 2.98 (95% CI, p = 0.000). The radiologic severity index ≥ 22.5 in initial chest X-ray signified a prevalence ratio of 2.24 (CI 95%, p = 0.004) and the radiologic severity index ≥ 29.5 in the second chest X-ray signified a prevalence ratio of 4.53 for the incidence of death (95% CI, p = 0.000). The combination of CURB-65 and the first chest X-ray radiologic severity index resulted in a prevalence ratio of 27.44, and the combination of CURB-65 and the second chest X-ray radiologic severity index resulted in a prevalence ratio of 60.2 which were significant for the mortality of hospitalized COVID-19 pneumonia patients.

Conclusions

Chest X-ray radiologic severity index and CURB-65 score have a significant relevance with the death event in hospitalized patients with COVID-19 pneumonia and can thus be used as a predictor of mortality.
MTPpilot: An Interactive Software for Visualization of Next-Generation Sequencing Results in Molecular Tumor Boards
Authors: Kahraman Abdullah , Arnold Fabian M. , Hanimann Jacob , Nowak Marta , Pauli Chantal , Britschgi Christian , Moch Holger , Zoche Martin
Published: August 2022

PURPOSE

Comprehensive targeted next-generation sequencing (NGS) panels are routinely used in modern molecular cancer diagnostics. In molecular tumor boards, the detected genomic alterations are often discussed to decide the next treatment options for patients with cancer. With the increasing size and complexity of NGS panels, the discussion of these results becomes increasingly complex, especially if they are reported in a text-based form, as it is the standard in current molecular pathology.

METHODS

We have developed the Molecular Tumor Profiling pilot ( MTPpilot) webservice using HTML, PHP, JavaScript, and MySQL to support the clinical discussion of NGS results at molecular tumor boards.

RESULTS

MTPpilot integrates various public genome, network, and cancer mutation databases with interactive visualization tools to assess the functional impact of mutations and support clinical decision making at tumor boards.

CONCLUSION

MTPpilot is tailored for discussion of NGS gene panel results at molecular tumor boards. It is freely available as a webservice at MTPpilot.
The Incidence and Risk Factors of Hyponatremia in Pulmonary Tuberculosis
Authors: Yoshida Tomohiko , Masuyama Hidenori , Yamagata Hiroki , Miyabayashi Makoto , Onishi Shunichiro , Inaba Yosuke , Takemoto Minoru
Published: August 2022

Context

The syndrome of inappropriate antidiuresis (SIAD) with euvolemic hyponatremia may occur in patients with pulmonary tuberculosis (PTB), but little is known about the clinical characteristics of SIAD-associated hyponatremia in PTB patients.

Objective

This study aimed to investigate the frequency and risk factors of hyponatremia in PTB patients.

Methods

In this retrospective chart review, we examined the incidence and severity of hyponatremia in PTB patients. Multivariate analysis was conducted to identify risk factors for hyponatremia in PTB patients.

Results

Of the 161 patients who were screened, after excluding patients with hyperglycemia and renal failure, we enrolled and analyzed data from 113 participants. Hyponatremia occurred in 40.7% patients (<135 mEq/L). Univariate analysis revealed that the presence of hyponatremia was associated with old age, female sex, low body mass index, high glycosylated hemoglobin, C-reactive protein (CRP), and N-terminal pro-brain natriuretic peptide. Multivariable analysis indicated that hyponatremia was strongly associated with old age (odds ratio, 1.06; 95% CI, 1.03-1.09 for every 1-year age increase) and CRP values (odds ratio, 1.15; 95% CI, 1.03-1.30 for every 1-mg/dL increase in CRP). For 86 patients with blood cortisol measurements, the cortisol level was significantly high in the hyponatremia group.

Conclusions

Hyponatremia was less frequently associated with hyperglycemia, heart failure, renal failure, and other diseases that cause euvolemic hyponatremia; thus, PTB patients may have euvolemic hyponatremia due to SIAD. Administration of hypertonic saline or fluid restriction should be considered in PTB patients with hyponatremia.
Exocyst inactivation in urothelial cells disrupts autophagy and activates non-canonical NF-κB signaling
Authors: Ortega Michael A. , Villiger Ross K. , Harrison-Chau Malia , Lieu Suzanna , Tamashiro Kadee-Kalia , Lee Amanda J. , Fujimoto Brent A. , Patwardhan Geetika Y. , Kepler Joshua , Fogelgren Ben
Published: August 2022

Ureter obstruction is a highly prevalent event during embryonic development and is a major cause of pediatric kidney disease. We have previously reported that ureteric bud-specific ablation of the gene expressing the exocyst subunit EXOC5 in late murine gestation results in failure of urothelial stratification, cell death and complete ureter obstruction. However, the mechanistic connection between disrupted exocyst activity, urothelial cell death and subsequent ureter obstruction was unclear. Here, we report that inhibited urothelial stratification does not drive cell death during ureter development. Instead, we demonstrate that the exocyst plays a critical role in autophagy in urothelial cells, and that disruption of autophagy activates a urothelial NF-κB stress response. Impaired autophagy first provokes canonical NF-κB activity, which is progressively followed by increasing levels of non-canonical NF-κB activity and cell death if the stress remains unresolved. Furthermore, we demonstrate that ureter obstructions can be completely rescued in Exoc5 conditional knockout mice by administering a single dose of the pan-caspase inhibitor z-VAD-FMK at embryonic day 16.5 prior to urothelial cell death. Taken together, ablation of Exoc5 disrupts autophagic stress response and activates progressive NF-κB signaling, which promotes obstructive uropathy.
A contabilidade de gestão e a aplicabilidade do método ABC no ensino superior militar da Academia Militar: um modelo de apoio à tomada de decisão e de desempenho
Authors: Gomes Paulo , Ribeiro António , Gimranova Fatima
Published: August 2022

O presente artigo tem como objetivo analisar a importância da contabilidade de gestão (CG) e a aplicabilidade do método activity based costing (ABC) no ensino superior militar português, nomeadamente no apoio à tomada de decisão e ao desempenho da Academia Militar (AM) portuguesa. A AM, sendo uma instituição de ensino superior militar, exige grande gestão de recursos financeiros e humanos para a formação de futuros oficiais de Exército e de Guarda Nacional Republicana, podendo ser favorecida com o uso da CG no seu apoio ao desempenho e à tomada de decisão. O Sistema de Normalização Contabilística na Administração Pública portuguesa (SNC-AP) exige informação que possa apoiar a gestão nos processos internos no apuramento de custos e na tomada de decisão de uma instituição. Dessa forma, o SNC-AP contempla a norma 27 (NCP 27) dedicada à CG, que se baseia no método ABC como forma de apuramento dos custos estruturais e dos produtos e/ou serviços. Ao nível da metodologia, foi efetuada uma análise quantitativa, mediante recolha de dados estatísticos por questionário, para testar as hipóteses. Recorreu-se a correlações entre variáveis, uma regressão linear múltipla e análise de diferenças estatísticas. A amostra recaiu em 32 militares e civis com responsabilidades no apoio à tomada de decisão e no desempenho organizacional da AM. Os resultados mostram que a CG constitui uma influência positiva para toda a estrutura organizacional da AM, mais precisamente ao nível organizacional tático (médio e longo prazo), relevando-se a importância dos recursos financeiros consumidos e dos produtos gerados pelas estruturas organizacionais.
Quantifying the effectiveness and health co-benefits of climate change mitigation actions across sectors: a protocol for an umbrella review
Authors: Belesova Kristine , Green Rosemary , Clercq-Roques Romain , Falconer Jane , Waddington Hugh Sharma , Whitmee Sarah , Reynolds Tamzin , Hassan Syreen , Haines Andy
Published: August 2022

Background: Effective and rapid actions are required to achieve global goals for climate change mitigation, and there is an opportunity to ensure that the actions taken are also positive for human health. However, little is known about the relative magnitude of the health co-benefits that can be achieved from mitigation actions, so robust and comprehensive syntheses of the evidence on the nature and effects of relevant actions are required. This paper presents a protocol for an interdisciplinary and cross-sectoral umbrella review of systematic reviews, synthesising modelled and empirical evidence on such actions.

Methods: Nine bibliographic databases will be searched, capturing literature across a wide range of disciplines and sectors. Unique records retrieved by the searches will be screened by two independent reviewers. The quality of all the included systematic reviews will be assessed using A MeaSurement Tool to Assess Systematic Reviews (AMSTAR) 2 critical appraisal tool. Data will be extracted on methodological and thematic characteristics of the reviews, nature of the actions, and their effects on greenhouse gas emission reduction, health, and its determinants, as well as any other reported effects and interactions across different actions.

Results: Narrative and quantitative synthesis methods will be used to create a typology of relevant actions, map pathways to their impacts on health, compare the magnitude of health and greenhouse gas (GHG) emission reduction impacts by selected characteristics of the actions and the nature of the evidence, as well as to identify gaps in evidence syntheses.

Conclusion: This review will identify the most effective actions for global climate change mitigation and health based on the best available scientific evidence.  

This protocol has been registered in PROSPERO, Reg No.: CRD42021239292.
Protocol: the complexity of informal caregiving for Alzheimer's disease and related dementias in rural South Africa
Authors: Manderson Lenore , Brear Michelle , Rusere Farirai , Farrell Meagan , Gómez-Olivé Francesc Xavier , Berkman Lisa , Kahn Kathleen , Harling Guy
Published: August 2022

Background: With aging, many people develop Alzheimer’s disease or related dementias (ADRD) as well as chronic physical health problems. The consequent care needs can be complicated, with heavy demands on families, households and communities, especially in resource-constrained settings with limited formal care services. However, research on ADRD caregiving is largely limited to primary caregivers and high-income countries. Our objectives are to analyse in a rural setting in South Africa: (1) how extended households provide care to people with ADRD; and (2) how the health and wellbeing of all caregivers are affected by care roles.

Methods: The study will take place at the Agincourt health and socio-demographic surveillance system site of the MRC/Wits Rural Public Health and Health Transitions Research Unit in Mpumalanga Province, northeast South Africa. We will recruit 100 index individuals predicted to currently have ADRD or cognitive impairment using data from a recent dementia survey. Quantitative surveys will be conducted with each index person’s nominated primary caregiver, all other household members aged over 12, and caregiving non-resident kin and non-kin to determine how care and health are patterned across household networks. Qualitative data will be generated through participant observation and in-depth interviews with caregivers, select community health workers and key informants. Combining epidemiological, demographic and anthropological methods, we will build a rich picture of households of people with ADRD, focused on caregiving demands and capacity, and of caregiving’s effects on health.

Discussion: Our goal is to identify ways to mitigate the negative impacts of long-term informal caregiving for ADRD when formal supports are largely absent. We expect our findings to inform the development of locally relevant and community-oriented interventions to improve the health of caregivers and recipients, with implications for other resource-constrained settings in both higher- and lower-income countries.
Frey syndrome
Authors: Egierska Dominika Magdalena , Perszke Michał , Grzelewski Aleksy , Cieślak Kamil , Berliński Miłosz , Świenc Witold , Tokarczuk Oskar
Published: August 2022

Frey syndrome is a condition of gustatory sweating and hyperemia related to damage of the auriculotemporal nerve. It affects around 80% of patients after parotidectomy. Syndrome may be easily diagnosed with an iodine-starch test, even in patients without symptoms, which are about 20% depending on studies. Authors searched PubMed and Google Scholar using searchterms Frey syndrome, auriculotemporal nerve, greater auricular nerve, tympanic nerve, parotidectomy. We manually searched the references of selected articles for additional relevant articles. We selected articles relevant to a general medicine readership and prioritized systematic reviews, clinical practice guidelines and cases. The literature contains the latest reports on Frey syndrome. Symptoms of Frey syndrome are: redding of the skin due to vasodilatation, excessive sweating or tingling and burning sensation of the cheek skin. Clinicians should pay attention to frey syndrome in patients after parotid gland surgery. Treatment includes botulinum toxin type A most commonly, topical injection of alcohol, scopolamine, glycopyrrolate and less common surgical treatment including transection of auriculotemporal nerve. Frey syndrome is not such a rare disease and should be always considered by clinicians because it may worsen the quality of patients' life.
Alcohol use and depression - literature review
Authors: Płaczek Alicja , Białas Filip , Baciur Patrycja , Skowrońska Katarzyna , Chmura Anna
Published: August 2022

Alcohol consumption has serious health and social consequences. A coexistence of alcohol use disorders and depressive disorders is common. Alcohol abuse is more common in men, but women are at greater risk of its harmful effects. Alcohol consumption in adolescence and early adulthood is associated with a higher risk of developing depressive disorders in the future. The order in which these disorders appear may vary, but it is important to make a diagnosis of depression during the period of abstinence. Drinking alcohol can be seen as a form of coping with stress and anxiety disorders. The aim of this article is to review the literature on the relationship between depression and alcohol.

Alcohol changes your neural pathways. Long and intense exposure may cause irreversible changes. The stress response pathways responsible for emotions and the reward system are the most sensitive. They deregulate the hypothalamic-pituitary-adrenal axis. Coexistence of alcohol use disorders and depressive disorders is treated primarily with antidepressants. Cognitive behavioral therapy has been shown to have a modest positive effect in relieving symptoms of depression and reducing the amount of alcohol consumed.
The treatment of polycystic ovary syndrome and systematization of knowledge - literature review
Authors: Cyboran Katarzyna , Płaczek Alicja , Machaj Dominik , Siedlak Agnieszka , Pondel Kamil
Published: August 2022

Polycystic ovary syndrome (PCOS) is a known disease among endocrinologists and gynecologists. The aforementioned disease entity affects up to six to twelve percent of women of reproductive age. [1] In 2017, the incidence among women of childbearing age was 82.44 per 100,000 population. A decade ago, it was 1.45% lower.[2] PCOS is a disease in which we have abnormal hormone levels. The result may be a problem with regular menstruation, problems with becoming pregnant, acne or excessive body weight. [3] Most often, patients arediagnosed only when complications occur. It is closely related to asignificant reduction in living standards. There are problems such as hair loss, acne and infertility.
Health effects of energy drinks on children, adolescents, and young adults
Authors: Kawałko Kinga , Rynio Grzegorz , Pondel Kamil , Karaś Anna , Bielewicz Krzysztof
Published: August 2022

Energy drinks are very popular nowadays. The number of people consuming this type of drink is growing every year, not only in the adult group but also in the population of adolescents and children. For many people, they are an alternative to stimulating coffee. In addition to the desired effects such as reducing fatigue, improving concentration and increasing physical and mental performance, energy drinks can also have adverse effects. The substances they contain, such as caffeine, taurine and large amounts of carbohydrates, may contribute to an increased risk of cardiovascular complications, metabolic and gastroenterological diseases, and mental disorders. [1] The aim of the article is to present the negative effects of consuming energy drinks in the population of adolescents and children.
The complement system and its role in the treatment of ANCA-associated vasculitis
Authors: Rybak Natalia , Dudek Iga , Czarnota Jakub , Dobrzyński Michał , Skubel Tomasz , Drozd Małgorzata
Published: August 2022

Objective: This study aimed to evaluate the role of the complement system in a therapy of the ANCA- associated vasculitis.

 

Methods and materials: A literature search was conducted in the PubMed MEADLINE database of medical publications using the following keywords: the complement system, AVV, C5a inhibitor, avacopan

 

Results: The complement system is a crucial part of the human immune system. Its cascade is involved in the pathogenesis of many disease entities, especially those with an inflammatory response. As anaphylatoxin, this is especially true of the C5a protein. C5a receptors are distributed mainly on tissue inflammatory cells, e.g. macrophages, mast cells, and endothelial cells. Therefore a C5a receptor inhibitor may reduce the inflammatory response of the body. This mechanism is used by the Avacopan, a newly approved drug for the treatment of ANCA-associated vasculitis as the main indication. Tavneos (avacopan) was only introduced in the UE in January 2022, as the first new drug to treat AVV in over a decade.

 

Conclusion: The C5a receptor inhibitor – Avacopan might be the future of a glucocorticoids-free or glucocorticoids – low dose therapy of ANCA-associated vasculitis. As the ADVOCATE clinical trial shows, Avacopan was neither superior, nor inferior to prednisone tamper with respect to sustained remission at 26 weeks, but proved to be superior with sustaining remission at 52 weeks. All the patients received rituximab or cyclophosphamide as a form of therapy.

 

Keywords: the complement system; C5a receptor inhibitor, AVV; Avacopan
Semaglutide for the treatment of obesity
Authors: Oleszczuk Rafał , Kozińska Iga , Gras-Ozimek Jordi , Kozińska Urszula , Oleszczuk Anna
Published: August 2022

Introduction and purpose

Due to the growing tendency to diagnose obesity in patients, scientists are trying to find drugs that facilitate weight reduction. 

An example of such a formulation is the GLP-1 analogue semaglutide. The following article is an analysis of the current knowledge on the effectiveness and safety of obesity treatment with semaglutide based on available publications in Pubmed and Google Scholar databases.

State of knowledge

The main mechanism of semaglutide is based on a stimulation of insulin secretion from pancreatic beta cells, and inhibition of glucagon from alpha cells, inhibition of hepatic gluconeogenesis, and reduction of energy consumption with minimal impact on energy expenditure. In clinical trials, it showed the best results compared to placebo and other drugs used in weight reduction. Participants treated with semaglutide achieved a reduction in waist circumference, improvements in blood pressure parameters, HbA1c levels, total cholesterol, LDL cholesterol, triglycerides, and CRP protein, and increased HDL cholesterol levels. Semaglutide is well tolerated by patients, and its main side effects come from the gastrointestinal tract, including nausea, emesis, diarrhea.

Summary

The analysis of the latest publications and meta-analyzes of the literature shows that the use of semaglutide is safe and effective in the treatment of obesity. The positive effect of semaglutide on weight reduction also contributes to the reduction of the risk of cardiovascular events and other obesity-related complications. It is also well tolerated by patients, which translates into possible longer use, and weekly subcutaneous injections are not burdensome for patients.

Key words: semaglutide; obesity; GLP-1 analogue; overweight
Operative treatment of hamate fractures with hamatometacarpal fracture dislocation using a self-designed dorsal buttress locking plate with trans-metacarpal pin insertion: short-term follow-up results
Authors: Kim Seok-Won , Lee Hyung-Joon , Park Ji-Kang , Chung Dong-Min
Published: August 2022

Purpose: Fracture and dislocation of the hamatometacarpal joint are rare; therefore, the diagnosis is frequently missed and the treatment is not clearly established. The authors performed operative treatment of hamate fractures with hamatometacarpal fracture dislocation using a self-designed dorsal buttress locking plate. Herein, we report the clinical and radiological results.Methods: From May 2016 to February 2022, we experienced 12 cases of hamatometacarpal fracture dislocation that underwent operative treatment with a self-designed dorsal buttress locking plate. All 12 patients were male, with an average age of 30.3 years and an average postoperative follow-up period of 6 months and 1 week. Open reduction and internal fixation were performed using a self-designed dorsal buttress locking plate with trans-metacarpal pin insertion according to the patient, and the results of the treatment were evaluated radiologically and clinically.Results: All cases showed bony union in radiological evaluations at the last follow-up. In functional evaluations using the modified Mayo wrist score, the results were excellent in 11 cases and good in 1 case. There were no complications such as fixation failure, nonunion, or infection.Conclusion: In cases of hamate fracture with hamatometacarpal fracture dislocation, the dorsal displaced fragment is very small, and it is often difficult to maintain reduction by direct fixation. In these fractures, operative treatment using a self-designed dorsal buttress locking plate with trans-metacarpal pin insertion can obtain good results.
Territórios e fronteiras espaciais e literários em “Dolly”, de Lygia Fagundes Telles
Authors: Quitério de Gois Amanda
Published: August 2022

Este trabalho tem por objetivo realizar uma análise a respeito do conto “Dolly”, de Lygia Fagundes Telles (2009), presente na obra A Noite Escura e Mais Eu, da mesma autora e do mesmo ano, a partir de uma leitura que utiliza-se de textos teóricos que abordam o território e as fronteiras para repensar o texto literário em questão e desenvolver a teoria de que a obra de Lygia Fagundes Telles escolhida para análise conversa diretamente com o espaço em que se insere, transformando, assim, os espaços geográficos em espaços literários, promovendo a junção de história e ficção.
A maçã no escuro, de Clarice Lispector: a leitura epistolar de Fernando Sabino e a questão do “tom conceituoso” e da emoção
Authors: Costa Fabrício Lemos da
Published: August 2022

RESUMOEste trabalho pretende refletir sobre a leitura de A maçã no escuro (1961), de Clarice Lispector (1920-1977), por Fernando Sabino (1923-2004). Essa recepção resultou numa contribuição realizada por meio de cartas trocadas pelos escritores entre Washington e Rio de Janeiro. Tratam-se de diálogos epistolares importantes na história do romance, pois neles se justificam mudanças textuais, como título, prefácio e trechos, os quais evidenciaram o que Sabino explicou ser um “tom conceituoso” na narrativa. Além disso, pelas cartas, é possível problematizarmos o aspecto da emoção, em que Clarice vai expor em suas correspondências, e que discutiremos a partir de seu projeto literário. Para este artigo, recorremos às reflexões de Nascimento (2012, 2021), Benjamin (2019) e Didi-Huberman (2021).Palavras-chave: A maçã no escuro, Clarice Lispector, Fernando Sabino, “Tom Conceituoso”, Emoção.
MUSCAFO digital: uma abordagem decolonial em Ambientes Virtuais de Ensino-aprendizagem
Authors: Silva Marcelo Prudente , Cerigatto Mariana Pícaro
Published: August 2022

Esse estudo apresenta o percurso metodológico da construção coletiva de um dispositivo pedagógico digital para o Museu Afro Comunitário Filhos de Obá, que integra o centenário terreiro de mesmo nome, uma das primeiras casas de culto afro no Brasil a ser tombada como patrimônio histórico nacional. Com o objetivo de contribuir para a difusão, reafirmação da identidade e preservação do seu acervo. E para tal, optou-se por trabalhar com a metodologia investigativa aplicada Design-Based Research, integrando especialistas acadêmicos convidados e a comunidade local. Utilizando-se de entrevistas qualitativas e diário de bordo. Os resultados englobam a apresentação do desenho pedagógico digital constituídos em imagens e mapas de navegação, com os pareceres dos participantes do processo e indicações dos possíveis desdobramentos e contribuições do estudo para as pesquisas em educação e comunicação.
(Fo)focar o eu com os olhos do outro: por um viés estético bakhtinano na pesquisa narrativa
Authors: Fujisawa Patrícia Yumi , Serodio Liana Arrais , Toledo Prado Guilherme do Val
Published: August 2022

Este texto trata de uma pesquisa realizada por meio de metodologia narrativa e conta o processo de mudança de posicionamento axiológico da professora-pesquisadora a partir de um artifício estético-ético: a fofoca. Na metodologia narrativa todos os momentos produtivos da pesquisa são narrativos. Para narrar, é necessário um ponto de apoio fora de si mesma para que a escrita seja produtiva esteticamente, o que altera também a posição axiológica da pesquisadora, o modo como se posiciona em relação aos valores em cada momento de interpretação das teorias e das materialidades narrativas. A fofoca como conversa entre amigas assume este papel estético e possibilita que a pesquisadora assuma outro posicionamento axiológico diante da interpretação das narrativas pedagógicas. A pesquisa fundamenta-se na filosofia da linguagem bakhtiniana.
Corpografias na leitura do literário
Authors: Neitzel Adair De Aguiar , Steil Isleide , Barontini Marcella
Published: August 2022

Este estudo, de caráter qualitativo e documental, trata das relações entre corpo e leitura do literário no espaço da escola. A pesquisa teve como objetivo discutir sobre a exploração do texto literário por meio de sensorialidades, da interação leitor e obra pela mediação corporal, a qual oportuniza a abertura das camadas de sentidos do texto. Esta pesquisa está alinhada aos estudos de Yunes (2016), Aguiar (2019), Duarte Jr. (2010), Brito e Jacques (2012), Autora e Autora (2019), entre outros. Sinalizam-se como resultados que a corpografia pode potencializar o envolvimento do aluno na leitura do literário. Mediações que proponham a exploração dos sons do texto, que deem vazão para a leitura dramática e o jogo dramático encaminham o leitor a penetrar nas camadas das tessituras literárias, estabelecendo uma relação sensível com a literatura.
Deslocamente social mediante a educação: tessituras da mulher pobre e periférica (1970-1994)
Authors: Fialho Lia Machado Fiuza , Freire Vitória Chérida Costa , Sousa Francisca Genifer Andrade de
Published: August 2022

O artigo trata do protagonismo feminino empreendido por uma menina pobre e negra, residente da periferia de Fortaleza, para conseguir ingressar na escolarização e prosseguir na educação formal, rompendo o semianalfabetismo geracional característico para as mulheres cearenses de sua etnia da década de 1960. O objetivo foi compreender os percalços e os deslocamentos vivenciados pela professora Zuleide Fernandes Queiroz na sua educação escolar e universitária que lhe possibilitaram resistir ao discurso conservador e às exclusões das instituições educacionais (1970-1994). Amparada teoricamente na história cultural e metodologicamente na história oral, desenvolveu-se uma pesquisa do tipo biográfica, que considerou como objeto de estudo as narrativas da biografada, coletadas mediante entrevista livre. Os resultados demonstram que, na contramão do percurso das outras meninas pobres, negras e periféricas do seu tempo, fadadas ao analfabetismo e ao subemprego, Zuleide Fernandes Queiroz conseguiu, com muita dificuldade, não apenas concluir a Educação Básica, mas tornar-se professora efetiva da Universidade Regional do Cariri. Sua trajetória educativa, marcada pela falta de recursos financeiros, foi ressignificada com a participação ativa nos movimentos estudantis, protagonizando a luta pelos direitos civis e de cidadania subtraídos às mulheres pobres, em especial, as negras.
A presença das mulheres na história da educação no Brasil
Authors: Guedes Rayane Silva , Ramos dos Passos Daniela Oliveira
Published: August 2022

O objetivo deste artigo é o de analisar a construção do campo da história da educação e a contribuição de algumas mulheres no que se refere ao reconhecimento das mesmas na educação brasileira. A partir da pesquisa de tipo qualitativa, por meio da análise documental, realizou-se uma busca pelo nome das educadoras, nos sites Google Book, Google Shopping, Estante Virtual, Amazon e Skoob por meio das palavras-chave “história da educação brasileira” e, a partir da seleção de livros “destaques”2 , de 33, escolheu-se 4 obras para análise. E, ainda, uma procura pelo site Google Books com o nome de cada educadora. Posteriormente realizamos uma busca da localização das obras, a partir de uma análise qualitativa, de forma a perceber se e como as educadoras são mencionadas nos textos. Assim como, a procura por trabalhos voltados para a temática nos sítios eletrônicos Google, Google Acadêmico e ANPEd. Dessa forma, foi possível verificar que há uma ausência dos nomes das influenciadoras nos livros de história da educação selecionados, mas existem pesquisas e projetos que buscam evidenciar as trajetórias das mulheres no campo temático, do ponto de vista de valorizá-las como protagonistas da educação no país.
Trajetórias socioeducacionais de mulheres negras no Amapá: rompendo relações de poder
Authors: Lima Adaíles Aguiar , Custódio Elivaldo Serrão
Published: August 2022

O presente artigo tem por objetivo refletir acerca da trajetória socioeducacional de professoras negras na vila de Mazagão Velho, estado do Amapá. As análises a partir da perspectiva decolonial permite-nos compreender as percepções dessas mulheres negras inseridas nos espaços sociais, seja na família, na escola, no trabalho e de que forma as experiências pessoais marcaram, marcam e demarcam sua presença nesses espaços. Como escolhas metodológicas optou-se, como método, o estudo de caso, através da pesquisa qualitativa narrativa, com observação direta e entrevista semiestruturada com sete professoras moradoras da vila de Mazagão Velho-AP. Os dados coletados foram tratados através da Análise do Discurso que permitiu-nos entender, através da linguagem, a interação entre as entrevistadas e o mundo em que estão inseridas, mostrando-nos que as trajetórias das entrevistadas trazem marcas da colonização que permanecem firmes, mascaradas pelo colonialismo, mas que são diária e arduamente combatidas através da luta e resistência contra as diversas formas de preconceito, discriminação racial e de gênero em face da mulher negra.
Emancipação da mulher artista: o caso da poetisa pernambucana Léa Tereza Lopes de Oliveira
Authors: Coelho de Andrade Gomes Graciele Maria
Published: August 2022

Neste artigo objetiva-se identificar e compreender o processo de emancipação da mulher artista pernambucana durante as décadas de 1960 a 1970 a partir da análise da vida e obra da poetisa Léa Tereza Lopes de Oliveira. É estudo conduzido a partir da metodologia da História Oral (ALBERTI, 2004) e tem por base teórica a História Cultural (CHARTIER, 2002) e a História das Mulheres (PERROT, 2017; 2019). Em acordo com a Metodologia da História Oral, os dados obtidos são resultado da realização de entrevista temática com a poetisa Léa Lopes. A fim de compreender o processo formativo da artista como mulher e a construção da sua poética na arte, coloca-se em discussão os conceitos de práticas e representações. A partir deste estudo foi possível observar que a vida e obra da poetisa exemplifica como a família, a escola e as redes de sociabilidade mantêm relação com a construção da subjetividade do sujeito e com seu processo de emancipação. Sua trajetória histórica revela a necessidade de uma educação que abra espaço para discussões sensíveis da vida, como a sexualidade, a formação política e dignidade. Deste modo, Léa Lopes, está entre as mulheres que experienciaram uma educação castradora nas décadas de 1960 e 1970 no Brasil e que utilizaram de manobras para fugir das relações androcêntricas que ainda no século XXI, estão presentes na sociedade.