Effects of Hepatitis C Virus (HCV) Eradication on Bone Mineral Density in Human Immunodeficiency Virus/HCV-Coinfected Patients
Authors: Carrero Ana , Berenguer Juan , Hontañón Víctor , Guardiola Josep M , Navarro Jordi , von Wichmann Miguel A , Téllez María J , Quereda Carmen , Santos Ignacio , Sanz José , Galindo María J , Hernández-Quero José , Jiménez-Sousa María A , Pérez-Latorre Leire , Bellón José M , Resino Salvador , Esteban Herminia , Martínez Esteban , González-García Juan ,   Grupo de Estudio del Sida (GESIDA) 3603B Study Group, Carrero A , Miralles P , López J C , Parras F , Aldamiz-Echevarría T , Tejerina F , Díez C , Pérez-Latorre L , Fanciulli C , Gutiérrez I , Ramírez M , Carretero S , Catalán P , Pérez M , Bellón J M , Berenguer J , Hontañón V , Arribas J R , Montes M L , Bernardino I , Pascual J F , Zamora F , Peña J M , Arnalich F , Díaz M , González-García J , Domingo P , Guardiola J M , Torrella A , Planas B , Curran A , Navarro J , Casado J L , Dronda F , Moreno A , Pérez-Elías M J , Sanfrutos M A , Moreno S , Quereda C , Arranz A , Casas E , de Miguel J , Schroeder S , Sanz J , Sanz J , Santos I , Bustinduy M J , Iribarren J A , Rodríguez-Arrondo F , Von-Wichmann M A , Vergas J , Téllez M J , Vinuesa D , Muñoz L , Hernández-Quero J , Ferrer A , Galindo M J , Ortiz L , Ortega E , Montero M , Blanes M , Cuellar S , Lacruz J , Salavert M , López-Aldeguer J , Pérez G , Gaspar G , Yllescas M , Crespo P , Aznar E , Esteban H 
Published: September 2020

Background

Little is known about the effects of eradication of hepatitis C virus (HCV) on bone mineral density (BMD) and biomarkers of bone remodeling in human immunodeficiency virus (HIV)/HCV-coinfected patients.

Methods

We prospectively assessed standardized BMD (sBMD) at the lumbar spine and femoral neck, World Health Organization BMD categories at both sites, and plasma concentrations of soluble receptor activator of NF-κβ ligand (sRANKL), and osteoprotegerin (OPG) at baseline (the date of initiation of anti-HCV therapy) and at 96 weeks.

Results

A total of 238 patients were included. The median age was 49.5 years, 76.5% were males, 48.3% had cirrhosis, 98.3% were on antiretroviral therapy, median CD4+ cell count was 527 cells/μL, and 86.6% had HIV-1 RNA &lt;50 copies/mL. The prevalence of osteoporosis at baseline at the lumbar spine (LS) and femoral neck (FN) was 17.6% and 7.2%, respectively. Anti-HCV therapy comprised pegylated interferon (peg-IFN) and ribavirin (RBV) plus 1 direct-acting antiviral in 53.4%, peg-IFN/RBV in 34.5%, and sofosbuvir/RBV in 12.2%. A total of 145 (60.9%) patients achieved sustained virologic response (SVR). No significant effect of SVR was observed on sBMD for the interaction between time and SVR either in the LS (P = .801) or the FN (P = .911). Likewise, no significant effect of SVR was observed in plasma levels of sRANKL (P = .205), OPG (P = .249), or sRANKL/OPG ratio (P = .123) for the interaction between time and SVR. No significant correlation was found between fibrosis by transient elastography, and LS and FN sBMD, at baseline and week 96.

Conclusions

SVR was not associated with significant changes in BMD nor biomarkers of bone remodeling in HIV/HCV-coinfected persons.