bluuebunny/crossref_metadata_2025 huggingface dataset:
Stipsi indotta da oppioidi: un problema emergente con nuove opportunità terapeutiche
Authors: Radaelli Franco , Di Paolo Dhanai
Published: January 2022

Non disponibile
Neutrality in public service interpreting
Authors: Balounová Zuzana
Published: January 2022

Most of the interpreting in the world today is done by public service interpreters. However, there has been a great deal of confusion regarding public service interpreting (PSI), specifically the role of the interpreter and neutrality in PSI. While codes of ethics assert that public service interpreters must act neutrally and impartially, users of PSI tend to view the interpreter as their advocate, making it difficult for the interpreter to maintain neutrality. In fact, as previous studies have shown, maintaining neutrality is one of the biggest challenges public service interpreters face. This article provides a review of the existing literature on the role of public service interpreters, ranging from early studies (e.g., Roberts, 1997; Wadensjö, 1998; Pöchhacker, 2000) via more recent work (e.g., Hale, 2008; Kalina, 2015; Valero Garcés, 2015) to the latest studies on the issue (e.g., Balogh & Salaets, 2019; Şener & Kincal, 2019; Runcieman, 2020). Using practical examples, the article analyses some of the existing codes of ethics and professional guidelines, which, as several authors suggest, are insufficient and should be reassessed. Throughout the paper, differences in different PSI settings (e.g., healthcare centres, schools, social services offices) are addressed.
Andrzej Zieliński (ed.) (2021). Las fórmulas de saludo y de despedida en las lenguas románicas. Sincronía, diacronía y aplicación a la enseñanza
Authors: Markič Jasmina
Published: January 2022

La monografía colectiva Las fórmulas de saludo y de despedida en las lenguas románicas. Sincronía, diacronía y aplicación a la enseñanza, editada por Andrzej Zieliński, profesor de la Universidad Jaguelónica de Cracovia (Polonia), ofrece novedosas aportaciones sobre las fórmulas de saludo y de despedida en diferentes lenguas románicas. Los dieciséis capítulos que componen este libro se organizan en siete secciones y están escritos en la lengua románica sobre la que se aborda el tema correspondiente (el italiano, el francés y el español). La excepción son los capítulos dedicados al rumano y al latín, escritos en inglés, y el capítulo dedicado al friulano que está escrito en francés. La mayoría de los autores son investigadores y profesores de la Universidad de Cracovia pero también contribuyeron a este volumen autores de otros centros universitarios y científicos de Polonia y otros países.
Reflective Practice in Anesthesia Clinical Teaching
Authors: Yamuragiye Assumpta , Anne Kinsella Elizabeth
Published: January 2022

BackgroundReflective practice is an essential aspect of knowledge generation for professional practice. By reflecting on action, professionals learn to improve their practices. Through processes of reflection, practitioners participate in a dialogue between theory and practice. Even though reflective practice is an important approach for learning from experience, its place remains unclear in anesthesia clinical education as well as anesthesia practice in a broad sense.AimThe aim of this paper was to examine the affordances of reflective practice in anesthesia clinical education.MethodsTwo cases, illustrating critical incidents in the anesthesia clinical teaching environment, were examined to consider how incorporating reflective practice into clinical education can advance knowledge generation in the field.FindingsThe two cases studies show how reflective practice can contribute to experiential learning, particularly through reflection on critical incidents.ConclusionReflective practice can help bridge the gap between theoretical knowledge and practice in anesthesia education and practice.Rwanda J Med Health Sci 2021;4(3):406-411
Physical Activity Levels of the Physiotherapy Students in Rwanda during the Coronavirus Disease 2019 Lockdown Period
Authors: Uwamahoro Sarah , Ayabagabo Benjamin , Nyamwasa Godfrey , Bucyana Emmy , Urimubenshi Gerard
Published: January 2022

BackgroundThe Coronavirus Disease 2019 (COVID-19) pandemic and related social distancing measures have an impact on physical activity levels.ObjectiveTo assess the physical activity (PA) levels of the physiotherapy students in Rwanda during the COVID-19 lockdown period.MethodsWe used a descriptive cross-sectional quantitative study design. Eighty-one participants were recruited, and data were collected using the International Physical Activity Questionnaire. We used descriptive statistics, Pearson Chi-Square and Kruskal-Wallis tests to assess whether there were statistically significant differences in physical activity levels according to demographic variables.ResultsThe median total PA metabolic equivalent of task (MET)-minutes/week score for all the participants together was 3546 (IQR=8714), meaning high PA. The rates for high, moderate, and low PA levels were 54.4%, 31.7% and 13.9% respectively. Male and rural participants had higher median total PA MET score than females (p=0.008) and urban residents (p=0.018) respectively.ConclusionsThe PA levels of the study participants during the COVID-19 lockdown period were higher than the recommended standards. Females and urban participants appeared to be less physically active than their counterparts. Further similar studies and interventions towards PA promotion among university students in Rwanda during the pandemic are suggested.Rwanda J Med Health Sci 2021;4(3):334-340
Incidence and Reasons for a Surgical Cancellation at a Hospital in Rwanda
Authors: Uwera Thierry , Mukantwari Joselyne , Ryamukuru David , A. Omondi Lilian
Published: January 2022

BackgroundSurgery cancellation is a challenging and costly event resulting in operating theatre inefficiency and psychological and financial problems for the patients and their families. This study aimed to find out the incidence and reasons for surgical cancellation at a Rwandan hospital.MethodsA retrospective study was conducted on 736 patients’ files obtained from theatre registry lists of surgical operations done from January to March 2017. The American Association of Perioperative Nurses (AORN) checklist for documenting cancelled surgical cases was used to establish the rate and reasons for cancellation. Data were analyzed using frequency and percentage descriptive statistics.ResultsOut of the 736 surgeries booked, 179 (24.3%) were cancelled as follows: Orthopedic and general surgeries (28.2%) respectively, gynecology and obstetrics (27.4%), urology surgeries (15.5%), maxillofacial surgeries (15.9%), ENT (15.6%) and plastic surgeries (13.3%). Time constrain/long list (19.6%), acute change in medical status (10.6%), non-turn-up of the patient (8.4%), and abnormal lab findings (7.8%) were the most prevalent reasons.ConclusionThe surgical cancellation rate at the study hospital was 24%, increasing with the number of patients booked and the type of surgical procedure. A prospective study is required to gain more insight into the reason for cancellations, mostly amenable to mitigation measures.Rwanda J Med Health Sci 2021;4(3):379-386
Sevoflurane induces lung cancer cell apoptosis via inhibition of the expression of miRNA155 gene
Authors: Wang Huaizhao , Wang Bin , Jing Jingyan , Li Na
Published: January 2022

Purpose: To determine the apoptotic effect of sevoflurane on lung cancer cells, and the underlying mechanism of action.Methods: Lung adenocarcinoma A549 cells were cultured for 24 h and divided into control group, 1% sevoflurane group and 3% sevoflurane group. The two levels of sevoflurane were provided through a gas monitor connected to each of the sevoflurane groups. The control group was not treated. Flow cytometry was used to analyze A549 cell apoptosis, while qRT-PCR was used for assay of the levels of miRNA155 in A549 cells. The protein expression of Bcl-2 was determined with immunoblotting. The percentage of apoptosis and levels of miRNA155 and Bcl-2 in the two cell lines were compared.Results: Significant differences in miRNA146a level were seen between the 3 % sevoflurane and control groups at 3 h. There was higher apoptosis in the 3 % sevoflurane group, relative to control, but miRNA155 levels in the 3 % sevoflurane group were generally less than that of the control (p < 0.05). There was lower Bcl-2 content in the 3 % sevoflurane group than in control group (p < 0.05).Conclusion: Sevoflurane exerts strong apoptotic and anti-proliferative effects on lung adenocarcinoma A549 cells via a mechanism which may be related to the downregulation of miRNA155, thereby inhibiting the expression of anti-apoptotic protein Bcl-2. This provides a new direction for research on anti-lung adenocarcinoma drugs.

Keywords: Sevoflurane, Lung cancer cells, Apoptosis, Inhibition, miRNA155, Expression, Induction
Sericea lespedeza (Lespedeza cuneata) whole plant extract enhances rat muscle mass and sperm production by increasing the activity of NO-cGMP pathway and serum testosterone
Authors: Mo SangJoon , Kim Eun Young , Choi Sun-Hyang , Lee Sanghyun , Lee Seong , Ahn Jin Chul
Published: January 2022

Purpose: To analyze the effects of an aqueous extract of Sericea lespedeza (SL) on rat male menopause.Methods: Levels of nitric oxide (NO), endothelial nitric oxide synthase (NOS), cGMP, and prostaglandin E2 (PGE2) in the penile corpus cavernosum of the rats were evaluated using appropriate kits. Serum levels of dihydrotestosterone (DHT), testosterone, sex hormone-binding globulin (SHBG), and 17-beta hydroxysteroid dehydrogenases (17β-HSD) were measured with enzyme-linked immunosorbent assay kits. Total and motile sperms were counted on a hemocytometer. Histological changes in rat testis and epididymis were analyzed with hematoxylin and eosin staining.Results: The levels of NO, NOS, and cGMP (but not PGE2) increased in a dose-dependent manner (p< 0.05) upon administration of an aqueous extract of SL (AESL), while levels of DHT, 17β-HSD, and testosterone increased in the group administered with 300 mg/kg of AESL. Epididymal sperm count increased by 24 % in such rats compared to controls (p < 0.05).Conclusion: The aqueous extract of SL improves sperm count and muscle mass in rats by increasing the levels of NO, NOS, cGMP and testosterone. Thus, SL extract can potentially be developed as an alternative therapeutic agent for clinical management of TDS.

Keywords: NO-cGMP, Testosterone, Hormones, Sperm count, Muscle mass, Sericea lespedeza, Lespedeza cuneata
Analysis of triterpenoids, carotenoids, and phenylpropanoids in the flowers, leaves, roots, and stems of white bitter melon (Cucurbitaceae, Momordica charantia)
Authors: Cuong Do Manh , Sathasivam Ramaraj , Park Chang Ha , Yeo Hyeon Ji , Park Ye Eun , Kim Jae Kwang , Park Sang Un
Published: January 2022

Purpose: To evaluate the contents of carotenoids, triterpenoids, and phenylpropanoids in different parts of white bitter melon.Methods: We evaluated the accumulation of 2 triterpenoids, 10 carotenoids, and 11 phenylpropanoids in different parts of white bitter melon, including fruits at four different developmental stages using HPLC.Results: Charantin, lutein, and rutin were the main triterpenoids, carotenoids, and phenylpropanoids, respectively. The accumulation of triterpenoids (momordicine and charantin), carotenoids (antheraxanthin, lutein, violaxanthin, α-carotene, and β-carotene), and phenylpropanoids (caffeic acid, chlorogenic acid, epicatechin, gallic acid, p-coumaric acid, rutin, and trans-cinnamic acid) was high inthe leaves and/or flowers, which are exposed to direct sunlight, but low in the roots.Conclusion: Most of the analyzed components were accumulated at high levels in the leaves and/or flowers. These results will help exploit the compounds in various parts of white bitter melon that are beneficial for human health.

Keywords: Momordica charantia, Bitter melon, Triterpenoid, Carotenoid, Phenylpropanoid
Assessment of awareness and satisfaction of online renewal of practising license among pharmacists in Nigeria
Authors: Okafor Ukamaka G. , Jatau Abubakar Ibrahim , Alabi Olukemi , Mohammed Elijah N.A.
Published: January 2022

Purpose: To assess the awareness and satisfaction of online renewal of practice licence among pharmacists in Nigeria.Methods: This was a cross-sectional study among pharmacists in Nigeria. Participants were recruited through; online (via social media platforms) or in person at Pharmacists Council of Nigeria (PCN) office during application for renewal of license.Results: A total of 878 participants completed the survey. Of this, 97.4 and 79.9 % were aware and satisfied with the online process, respectively. The respondents rated the process as excellent (19.1 %), fair (22.2 %), good (55.0 %) and poor (3.6 %). Most of the reported challenges included linking payment of association dues with license renewal, poor customer service and password retrieval.Conclusions: The level of awareness and satisfaction of the online renewal of annual licence among pharmacists in Nigeria is high. Measures are still needed to improve the online application process.

Keywords: Pharmacists Council, Online, Licence, Pharmacist, Practice
Assessment of the relationship between depression and treatment compliance in chronically-ill patients in Jeddah, Saudi Arabia
Authors: Almohammadi Ameen Mosleh , Bawazeer Somayah Saeed , Balkhair Joud Jamal , Rajab Aroub Adel
Published: January 2022

Purpose: To find the relationship between depression, treatment adherence and lifestyle changes inchronically-ill patients residing in Jeddah, Saudi Arabia.Methods: A cross-sectional study was conducted. A self-administered questionnaire was used tocollect data from patients of multi-healthcare centers located in Jeddah. The questionnaire aimed tocollect the information regarding patients’ levels of medication compliance, patients’ capacity to copewith the disease and adherence to medication, along with their depression level.Results: Of the overall sample size of 439 patients, 43.1 % were suffering from hypertension, 37.8 %were diabetic and 33.7 % had hyperlipidemia. Besides, total scores of Patient Health Questionnaire-9(PHQ-9) showed that approximately 5 % patients were severely depressed, 8 % had moderately severedepression, 27 % had moderate depression, and 60 % had mild depression. Compliance scale datarevealed that 38 % patients showed low compliance, 51 % showed partial compliance, and 11 %showed high compliance. Also, a significant inverse relationship between depression and compliancescales (rs = -0.221, p = 0.004) was observed.Conclusion: The results show an inverse association between depression and medication adherencein patients with chronic disease in Jeddah. Therefore, clinicians are advised to assess the level ofdepression in chronically-ill patients in order to improve their adherence to medicine.Keywords: Chronic illness, Depression, Medication adherence, Treatment compliance
Leonurusine hydrochloride promotes osteogenic differentiation via Wnt/β-catenin pathway and expression of Runx2
Authors: Chen Xiaobo , Lai Xiaoyu , Sun Xiaoyon , Wang Maoyuan , Cai Yu
Published: January 2022

Purpose: To investigate the effect of leonurusine hydrochloride (LH) on osteogenic differentiation, and the involvement of Wnt/β-catenin route and runt-associated transcription factor 2 (Runx2) in the process.

Methods: Mouse osteogenic precursor cell line MC3T3-E1 was used. The cells were assigned to control and three other groups treated with increasing doses of LH, i.e., 0.1, 1, and 10 μmmol/L. Cellular differentiation was determined in the various groups with respect to mRNA expressions of alkaline phosphatase (ALP), number of calcified nodules, Wnt/β-catenin pathway-related genes, viz, 5 (LRP5),β-catenin, GSK-3β, as well as mRNA expressions of related osteogenic differentiation genes, namely. alkaline phosphatase (ALP), alpha 1 type I collagen (Col1-α), Run×2, and osteogenic-related transcription factor antibody (Osterix) using reverse transcription polymerase chain reaction (RT-PCR).

Results: The secretion levels of ALP in cells exposed to LH doses of 1 and 10 μmmol/L were significantly increased, relative to control values (p < 0.05). There were marked increases in mRNA levels of LRP5 and β-catenin in cells treated with LH doses of 1 and 10 μmmol/L compared with the control group, while GSK-3β mRNA expression levels were significantly lower than that in control group(p < 0.05). However, the expression levels of ALP, Col1-α, Run×2, Osterix mRNA in cells exposed to LH at doses of 1 and 10 μmmol/L were significantly higher than the corresponding expression levels in control cells (p < 0.05).

Conclusion: Leonurusine hydrochloride may promote osteogenic differentiation and bone mineralization via a mechanism involving activation of the Wnt/β-catenin pathway and up-regulation of Run×2 expression.

Keywords: Leonurusine hydrochloride, Wnt/β-catenin, Runx2, Osteogenic differentiation
Mir-23b down-regulates the expression of target gene of acetaldehyde dehydrogenase 1a1 and increases the sensitivity of cervical cancer stem cells to cisplatin
Authors: Tao Yongbing , Mao Fuyun , Gu Weihong , Wu Ling , Guo Jing , Xu Ping
Published: January 2022

Purpose: To study the effect of miR-23b on the expression of the target gene of acetaldehyde dehydrogenase 1A1 (ALDH1A1), and cisplatin (CDDP) susceptibility of cervical carcinoma stem cells.

Methods: Human cervical cancer cell line Hela cells were cultured in vitro, and miR-23b mimic and negative control were transfected into the cells using lipofectamine method. The growth of the two groups of cells was determined using growth curve method, and their proliferation measured using plate clone formation. The influence of treatments on the sensitivity of the cells to CDDP was assayed using MTT method. The mRNA expression of ALDH1A1 in Hela cells was assayed using real-time quantitative polymerase hain reation (PCR), while its protein expression was assayed by Western blot.

Results: The levels of expressions of ALDH1A1 protein and mRNA in the miR-23b overexpression group were significantly lower than those in the control group (p < 0.05). The sensitivities of Hela cells to CDDP in the ALDH1A1 inhibition group and the control group were dose-dependent to some extent, but cell inhibition in ALDH1A1 inhibition group markedly increased, relative to control when the CDDP dose was 0.1 ppc (p < 0.01).

Conclusion: Up-regulating the expression of miR-23b significantly inhibits the growth and proliferation of cervical cancer cells, and increases their sensitivity to CDDP via down-regulation of the expression of the target gene for ALDH1A1. Therefore, during cervical carcinoma treatment, increasing the level of miR-23b may produce a chemotherapeutic effect.

Keywords: MiR-23b, Acetaldehyde dehydrogenase 1A1, Cervical cancer, Cisplatin, Sensitivity
Serum Sestrin2 and PlGF levels in pregnant women with pre-eclampsia and their correlations with the severity of the disease: A case-control study
Authors: Li Lijun , Sun Zhen , Liu Shasha , Cui Hongyan
Published: January 2022

Purpose: Sestrin2, a metabolic regulator with antioxidant activity, might have some certain predictability for the occurrence and severity of pre-eclampsia (PE). The purpose of this work was to explore the levels of serum Sestrin2 and PlGF in pregnant women with PE and their correlation with the severity index of the disease.Methods:This was a retrospective case-control study of pregnant women with PE who planned to give birth in our hospital from 05/2017 to 05/2019. Pearson correlation was used to analyze Sestrin2 and PlGF levels with PE severity. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of Sestrin2 and PlGF for PE.Results: There were 52 women in the control group, 46 in the mild PE group, and 36 in the severe PE group. As the severity of PE increased, the median levels of Sestrin2 increased (8.1, 9.8, and 11.8 ng/ml), and the levels of PlGF decreased (156, 117, and 67 pg/ml) in the three groups of women (all P<0.05).The levels of Sestrin2 and PlGF were strongly correlated with mean arterial pressure,proteinuria, newborn birth weight and gestational weeks at delivery (all P<0.001). Sestrin2 and PlGF had high efficiency of diagnosing PE (cut-off: 8.90 ng/ml, Area Under Curve [AUC]=0.979; cut-off: 122.50 pg/ml, AUC=0.963). Additionally, Sestrin2 and PlGF showed high value of severity prediction (cut-off: 11.15 ng/ml, AUC=0.857; cut-off: 68.50 pg/ml, AUC=0.837).Conclusion: Sestrin2 and PlGF are correlated with the severity of PE. Both Sestrin2 and PlGF had high value for PE diagnosis and severity prediction.

Keywords: pre-eclampsia; Sestrin2; placental growth factor; oxidative stress; severity
Studies of the pharmacokinetics of morroniside and loganin in rat after oral administration of raw and wine-processed Corni fructus by UPLC-QqQ-MS/MS
Authors: Wang Wei , Wang Xuechun , Zhang Qiang , Jia Ru , Du Chunjie , Ju Chengguo
Published: January 2022

Purpose: To study the pharmacokinetics of morroniside (MR) and loganin (LG) in rats after oral administration of raw and wine-processed Corni fructus by UPLC-QqQ-MS/MS.

Methods: Arctiin (AT) was used as internal standard, and the plasma or tissue samples were extracted twice using ethyl acetate. Electrospray ionization (ESI) negative ion mode was used, and the multiple reaction monitoring mode (MRM) was set in acquisition mode. The extraction and detection method is supported by selectivity, sensitivity, precision, accuracy, stability, extraction, recovery and matrix effect. The non-atrioventricular model of das2.0 software was used to calculate the pharmacokinetic parameters.

Results: The absorption rate of MR (PTmax=0.092) and LG (PTmax=0.092) in Corni Fructus after wine-processing was faster in rats. The mean residence time was longer, and distribution of MR (PMRT0~t = 0.294) and LG (PMRT0~t = 0.000) in wine-processed Corni Fructus group increased in liver and kidneys.

Conclusion: The proposed method has been successfully validated and is suitable for studying the pharmacokinetics of the two analytes in rats.
Anticancer effect of 7-hydroxycoumarin in cisplatin-resistant ovarian cancer cell is mediated via apoptosis induction, caspase activation and cell cycle arrest at G2M phase
Authors: Wang Hongmei , Wang Yina
Published: January 2022

Purpose: To investigate the anticancer effects of 7-hydroxycoumarin against cisplatin-resistant ovarian cancer cell line, and the underlying mechanism(s).

Methods: Cell proliferation was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The 4’,6-diamidino-2-phenylindole (DAPI) and acridine orange/ethidium bromide (AO/EB) dual staining methods were used for measuring cell apoptosis in terms of DNA damage. Flow cytometry was used for analysis of mitosis of cancer cells, while protein expression levels were assayed with western blotting.

Results: The 7-hydroxycoumarin preferentially inhibited the proliferation of the ovarian cancer cells, but had significantly less prominent effects on normal cells (p < 0.05). The decrease in cell proliferation was due to induction of cell apoptosis via caspase-linked apoptotic pathway. Treatment with 7- hdoxycoumarin further led to the arrest of cancer cell cycle at G2/M stage (p < 0.05) via down-regulation of the expressions of regulatory proteins that promote mitotic entry.

Conclusion: 7-Hydroxycoumarin exerts significant anticancer effect against cisplatin-resistant ovarian cancer cells via decrease in cell proliferation, induction of apoptosis and mitotic cell cycle arrest. Thus, the compound could emerge as a vital lead molecule in the treatment of cisplatin-resistant type of human ovarian cancer.
KORELASI KECANDUAN MOBILE LEGENDS TERHADAP PRESTASI BELAJAR MAHASISWA
Authors: Irwandi Diki , Masykur Ruhban , Suherman Suherman
Published: January 2022

The purpose of the study was to determine the correlation between the level of online game addiction and student achievement in the Mathematics Education Study Program, UIN Raden Intan Lampung. The method in this research was quantitative with the type of correlation research. The data collection technique used a questionnaire and tested it to see the validity and reliability. The data analysis technique in this study used the normality test using the Kolmogorov Smirnov method and the linearity test using SPSS software version 24.0, and hypothesis testing using a correlation test with a significant level of 0.05 or 5%. The study results were that of the 30 questionnaires tested, 25 questions were feasible to use. The reliability test has a value of rcount > rtable. The normality test got a significant value of 0.065 and 0.066 on online game addiction and learning achievement. So it can be said that there is a significant correlation between student achievement and online game addiction, and the value is 0.307, which means correlation
Pediatri Hemşirelerinin Kendi Mesleklerine İlişkin Metafor Algılarının Değerlendirilmesi
Authors: KARAKUL Atiye , DOĞAN Pınar , ÖZGÜVEN ÖZTORNACI Beste
Published: January 2022

Giriş: Metaforlar, bir kavramın açıklanması ya da anlatılması, kavramın daha kolay anlaşılmasını sağlamaktadır. Metafor odaklı çalışmaların hemşirelikte kullanımı ile mesleğin hemşireler tarafından nasıl algılandığının anlaşılmasını ve mesleğin daha iyi analiz edilmesini kolaylaştırmaktadır. Amaç: S Bu çalışmanın amacı, pediatri hemşirelerinin kendi mesleklerine ilişkin algılarını, metaforlar aracılığıyla ortaya çıkarmaktır. Yöntem: Çalışma nitel araştırma yaklaşımlardan biri olan olgu bilim (fenomenoloji) yaklaşımı kullanılarak yapılmıştır. Araştırmanın örneklemini, Türkiye’de pediatri servislerinde görev yapan 163 hemşire oluşturmuştur. Araştırma verileri Google Form aracılığıyla online olarak, 6 Temmuz-1 Eylül 2020 tarihleri arasında toplanmıştır. Verilerinin toplanmasında kullanılan veri toplama formu, katılımcıların tanıtıcı bilgilerini ve pediatri hemşireliğini nasıl algıladıklarını içeren “Pediatri hemşiresi… gibidir, çünkü…” metafor cümlesinin yer aldığı iki bölümden oluşmaktadır. Elde edilen verilerin değerlendirilmesinde “içerik analizi tekniği” kullanılmıştır. Bulgular: Çalışmaya katılan hemşirelerinin yaş ortalaması 30.81±7.16’dır (minimum: 21, maksimum: 55). Pediatri hemşirelerinden toplam 51 farklı metafor elde edilmiştir. Elde edilen metaforlar olumlu, olumsuz ve hem olumlu hem olumsuz olmak üzere üç kategoriye ayrılmıştır. Olumlu kategoride üretilen 23 (%45) metafor; olumsuz kategoride üretilen 14 metafor (%27,5) ve hem olumlu hem olumsuz kategoride ise 14 metafor (%27,5) yer almaktadır. Katılımcıların 10’unun, pediatri hemşireliği ile ilgili belirtmiş olduğu ifadenin metafor özelliği taşımadığı saptanmıştır. Metaforların gerekçeleri incelendiğinde ise; olumlu kategoride yer alan metaforların, genellikle pediatri hemşireliğinin anne, baba, teyze gibi algılanarak bakım verici yönünün gerekçelendirildiği belirlenmiştir. Olumsuz kategoride yer alan metaforların, ek iş yüklerinin fazla olması, çalışma saatleri ve koşullarına yönelik gerekçeler olduğu görülmüştür. Hem olumlu hem olumsuz kategoride yer alan metaforların gerekçeleri ise pediatri hemşireliğinin çalışma koşullarının yorucu ve yıpratıcı olmasına rağmen çocuklarla birlikte çalışmanın olumlu duyguları ile ilgili olduğu belirlenmiştir. Sonuç: Sonuç olarak, pediatri hemşirelerinin çoğunluğunun olumlu kategoride yer alan metafor ürettiği belirlenmiştir. Pediatri hemşirelerinin mesleki beklentilerinin belirlenmesi, mesleki motivasyonlarının artırılması için çalışma şartlarının iyileştirilmesi önerilebilir.
Spinal Müsküler Atrofisi Olan Çocuk ve Ailesinin Hemşirelik Bakımı
Authors: AKGÜN KOSTAK Melahat , ÇETİNTAŞ İsmail
Published: January 2022

Spinal müsküler atrofi (SMA), sıklıkla otozomal resesif geçişli ilerleyici dejenerasyon ile seyreden nöromusküler kalıtımsal bir hastalıktır. Erken bebek ölümlerinin en yaygın genetik nedeni olan SMA dünyada yaklaşık 6.000-10.000 canlı doğumda bir görülürken, ülkemizde insidansı yaklaşık 1/6.000 canlı doğumdur. SMA’da omuriliğin ön boynuz hücrelerinde alfa motor nöronların dejenerasyonu istemli kasları etkileyerek proksimal simetrik güçsüzlüğe, ekstremitelerde ve gövdede atrofiye neden olur. Dört klinik tipi olan SMA’da yaşam kalitesi tipe göre farklı olmakla birlikte sık görülen Tip 1 ve Tip II formunda ileri dejenerasyona bağlı kas atrofileri nedeniyle çocuklar tam bağımlı hale gelirler. Dünyada ve ülkemizde SMA tedavisi için bazı ilaçlar kullanılmasına karşın hastalığın henüz tam iyileşme sağlayan bir tedavisi yoktur. Bu nedenle SMA’lı çocuk ve ailenin/ebeveynlerin çocuklarının bakımı konusunda desteklenmeleri, çocuklarının bakım gereksinimleri konusunda eğitilmeleri önemlidir. SMA’lı çocuk ve ailesinin bakımında hemşireler önemli bir role sahiptir. Yapılan literatür taramasında ülkemizde SMA tedavi ve bakımı ile ilgili yayınların çok sınırlı olduğu görülmektedir. Bu derlemede, ülkemizde son yıllarda güncel bir sorun olarak karşımıza çıkan SMA hastalığı, tedavisi ve hemşirelik bakımı ele alınmıştır.
MOŽNOSTI ŘEŠENÍ SVOZNĚ ROZVOZNÍ ÚLOHY S HETEROGENNÍM VOZOVÝM PARKEM
Authors: Brázdová Markéta
Published: January 2022

Příspěvek se zabývá problematikou svozně rozvozních úloh s heterogenním vozovým parkem. Svozně rozvozní úlohy představují složitý optimalizační problém obvykle s mnoha omezujícími podmínkami. Pro úlohu s vozovým parkem zahrnujícím různé typy vozidel charakterizovaných dílčími parametry předkládá článek tři základní varianty řešení úlohy. První možností je seřazení vozidel podle jednoho jejich parametru, druhou možností je rozdělení vozidel do skupin tak, aby všechny parametry vozidel ve skupině byly shodné. Třetí varianta, která je také z hlediska optimalizačního nejvýhodnější, je kombinace třídění vozidel do skupin se současným zohledněním přípustnosti vozidla pro objednávku.
OVLIVŇUJE CENOVÁ KOTVA V DOPRAVĚ VŠECHNY GENERACE STEJNOU MĚROU?
Authors: Pojkarová Kateřina
Published: January 2022

Mnoho publikací bylo napsáno o působení kognitivních klamů při rozhodování, ať už je tím klamem paradox volby, efekt volavky, haló efekt nebo klam dostupnosti. Tento článek se zaměřuje na efekt kotvy neboli vtisknutí. Lidé mají tendenci nechat se ovlivnit v podstatě jakýmkoli číslem, které uvidí před rozhodováním o ceně zboží a jeho nákupu. Otázkou zůstává, zda se všechny generační skupiny nechají ovlivnit stejným způsobem, nebo jestli jsou různé generace různě citlivé na působení kotvy. Tato otázka byla soustředěna na oblasti rozhodování o ceně letenky, kde proběhl průzkum mezi různými generacemi. Nejen na základě analýzy rozptylu pak bylo možné konstatovat, že mladší generace jsou na vliv kotvy citlivější než ty starší.
Hábito y conflicto en Hegel
Authors: Duque Félix
Published: January 2022

Nada más habitual que el hábito. Y, sin embargo, de seguir a Aristóteles, no existirían virtudes entre nosotros, o sea: aptitudes y habilidades que acaban por configurar la existencia humana. En este ensayo se examina el desarrollo dialéctico del hábito en Hegel, desde la Antropología hasta la Eticidad (Filosofía del Derecho): en el plano individual, desde el estado fetal y el desvarío en el alma sentiente hasta el autosentimiento de sí y el nacimiento del Yo; en el plano colectivo, se atiende más bien a la génesis del hábito y sus fautores: las corporaciones, las instituciones estatales y la opinión pública, hasta desembocar en el extraño estadio del hábito como deshabituación de todo hábito, en el fenómeno de la guerra. Se pone así de relieve el modo en que el hábito es el modo crucial de ser entre la individualidad animal y el cuerpo sociopolítico como aparato mecánico que promete vida y amenaza muerte.
Actitud hacia las iniciativas de ayuda social y su efecto en la intención de realizar donativos por parte de los habitantes de la ciudad de Guayaquil
Authors: Cedillo Gisell , Márquez Angie
Published: January 2022

El presente estudio busca conocer si la actitud hacia la ayuda a otros individuos o la actitud hacia la ayuda a organizaciones de ayuda social poseen un efecto mayor en la intención de realizar donativos por parte de los habitantes de Guayaquil, teniendo en cuenta el aumento de organizaciones no lucrativas. Se aplicaron cuestionarios para ampliar la perspectiva tomando en consideración dos constructos: Actitud para ayudar a los demás y Actitud hacia las organizaciones benéficas de Webb, Green y Brashear (2000). Además, de variables como la motivación y el destino de los donativos. Como resultados de la búsqueda y metodología aplicada se obtuvo que los habitantes de la ciudad de Guayaquil poseen mayor aceptación a ayudar por medio de organizaciones benéficas a las diferentes causas, su mayor motivación a dar donativos se da cuando existe una emergencia, sí su destino es a fundaciones que ayudan a personas con enfermedades terminales. También, reflejó que el género femenino tiene mayor intención a donar. Se concluye que las organizaciones benéficas a pesar de tener una gran aceptación por parte del público no deben descuidar la imagen positiva que ya poseen.
El Teletrabajo y su incidencia en la percepción de la Felicidad Laboral
Authors: Santana María de los Ángeles , Cueva Jorge , Sumba Nicolás , Delgado Figueroa Stella Paola
Published: January 2022

El teletrabajo fue una alternativa para que el mundo continúe sus actividades económicas, durante la pandemia por la COVID-19, su presencia ha mostrado nuevas oportunidades en el mundo empresarial, sin embargo, se hace necesario indagar sobre el bienestar y la felicidad de los empleados que laboran en esta modalidad de trabajo. El objetivo del estudio fue: analizar la incidencia del teletrabajo, sobre la felicidad laboral en los colaboradores de la ciudad de Guayaquil. Para esto se realizó un estudio de tipo descriptivo tanto de variables cualitativas como cuantitativas, las entrevistas se realizaron a cinco expertos en áreas de talento humano y gerentes de empresas, mientras que la encuesta fue dirigida a 387 trabajadores que hayan realizado trabajo presencial y teletrabajo. Se observa un decremento en los niveles de satisfacción laboral a través de la modalidad de teletrabajo. Se concluye que los niveles de felicidad laboral por parte de los trabajadores han sido influenciados negativamente durante el teletrabajo debido a factores como: el aumento de actividades y el hecho de no contar con las herramientas y el ambiente adecuado para ejercer su labor.
IMPLEMENTASI PROGRAM KOMUNITAS BACA TULIS (KOBATU) SMK NEGERI 2 TEGAL DI MASA PANDEMI
Authors: Fauziah Fauziah
Published: January 2022

Tujuan dari penelitian ini adalah sebagai berikut. (1) Mendeskripsikan bagaimana implementasi program kobatu untuk meningkatkan kompetensi peserta didik dalam menulis dan membaca karya sastra. (2) Mendeskripsikan bagaimana hasil dan dampak yang dicapai pasca implementasi program kobatu. (3) Mendekripsikan kendala apa saja yang terjadi pada pengimplementasian program kobatu. (4) Mendeskripsikan faktor apa saja yang mendukung pelaksanaan implementasi program kobatu. Teknik pengumpulan data dalam penelian ini menggunakan metode observasi, wawancara, dan kajian pustaka. Sedangkan teknik analisis data menggunakan metode analisis deskriptif kualitatif. Hasil penelitian menunjukkan, implementasi program kobatu untuk meningkatkan kompetensi peserta didik dalam menulis dan membaca karya sastra antara lain dengan perekrutan anggota, latihan atau sharing, dan launching produk. Hasil dan dampak yang dicapai pasca implementasi program kobatu antara lain peserta didik yang tergabung dalam anggota komunitas semakin meningkat kompetensinya dalam mencipta karya sastra yang diwujudkan dalam produk berupa antologi. Hal ini juga semakin membuat peserta didik lebih percaya diri. Selain itu, Kobatu dapat menjadi program unggulan sekolah dan diakui secara resmi oleh Perpusnas RI. Kendala yang terjadi pada pengimplementasian program kobatu tidak terlalu berarti, hanya masalah waktu latihan yang terbatas dan pemahaman peserta didik yang tidak sama. Faktor yang mendukung pelaksanaan implementasi program kobatu antara lain dari pihak sekolah, peserta didik, dan guru.
SELECTION OF OBTURATIONS MATERIALS IN PULPECTOMY TREATMENT OF DECIDUOUS TEETH
Authors: Hartomo Bambang Tri , Tanjung Laksmita , Romdlon Mahindra Awwaludin , Oktadewi Fitri Diah
Published: January 2022

Introduction: Pulpectomy is the procedure of taking the entire pulp tissue from all the roots and corona of a tooth. There are several materials for obturation / root canal fillers in deciduous teeth, namely zinc oxide eugenol (ZOE), calcium hydroxide and iodoform paste a mixture of calcium hydroxide. A 6 year old boy patient came to RSGM with his parents seeking for treatment a tooth with a large cavity in the upper left posterior region and had been pain before. Intraoral examination revealed deep caries in the occlusal tooth 65 which reaching the pulp, percussion (-), palpation (-), mobility (-), vitality (-). Radiographic examination of tooth 65 showed a radiolucent image that had reached the pulp and the root canals had not yet undergone resorption. The diagnosis of this case was pulp necrosis at tooth 65. Case management: The treatment plan to be carried out was non-vital pulpectomy on tooth 65 and used technique non-vital pulpectomy because the tooth had already necrosis. Discussion: The filler used is ZOE. The reason for choosing this material was because it was indications for the use of ZOE material for teeth with necrosis. Conclussion: ZOE has anti-inflammatory and analgesic properties that can reduce pain
PENGEMBANGAN AUTOMATIC LESSON PLAN GENERATOR
Authors: Santosa Donald Samuel Slamet , Pujiastuti Ani , Mahmud Yogi Saputra
Published: January 2022

Penelitian ini berangkat dari permasalahan tingginya kesenjangan antara perencanaan pembelajaran yang disusun oleh guru dengan pelaksanaannya. Tujuan dari penelitian ini adalah mengembangkan Automatic Lesson Plan Generator, yaitu perangkat lunak dalam bentuk prototypeang dapat menyediakan perencanaan pembelajaran yang paling tepat untuk kondisi yang dihadapi oleh guru. Penelitian ini adalah penelitian pengembangan (Research and Development) yang menggunakan metode Plomp. Metode penelitian yang digunakan adalah penelitian kualitatif. Pengumpulan data dilakukan melalui observasi, wawancara dan FGD, kemudian di validasi dengan triangulasi sumber dan teknik. Analisis data dalam penelitian ini menggunakan teknik Miles dan Huberman. Hasil penelitian berupa prototype model Automatic Lesson Plan Generator. Model automatic lesson plan generator dikembangkan dengan memperhatikan karakteristik siswa, bahan ajar, capaian pembelajaran, kondisi fisik kelas, sehingga output dari model ini adalah dapat menghasilkan RPP yang sesuai dengan kebutuhan dan kondisi guru, siswa, dan lingkungan belajar. Berdasarkan hasil analisis data dan mekanisme kerja model automatic lesson plan generator, maka dapat diketahui bahwa model ini memudahkan guru dalam menyusun RPP sekaligus meminimalkan kegagalan realisasi dari RPP yang dibuat. Kegiatan penyaringan dan penilaian metode menjadikan RPP yang disusun sesuai dengan kebutuhan dan kondisi dari guru, siswa, dan lingkungan belajar di mana hal tersebut sering kurang diperhatikan oleh guru. Terdapat 5 langkah kerja dari model automatic lesson plan generator yang dikembangkan, yakni: tahap pengisian data pembelajaran, tahap analisis dan pengelompokan data pembelajaran, tahap penyaringan metode, tahap penilaian metode, dan tahap penyusunan RPP.
IMPLEMENTASI APLIKASI METODE FUZZY MAMDANI UNTUK PERENCANAAN PRODUKSI AIR MINERAL
Authors: Suprianto Suprianto , Agustin Wilda
Published: January 2022

Perencanaan adalah suatu kewajiban yang harus dimiliki oleh setiap perusahaan di setiap bidang usaha dikarenakan sangat mempengaruhi tingkat keuntungan. Penelitian ini bertujuan untuk menghitung jumlah produksi air mineral pada CV Tirta Jaya Mandiri agar tidak terjadi kelebihan atau kekurangan produksi yang dihasilkan sehingga permintaan pasar dapat terpenuhi sesuai kebutuhan. Metode yang digunakan dalam penelitian ini adalah metode fuzzy mamdani dengan melakukan pembentukan himpunan permintaan dan persediaan dari data yang telah dimiliki yang akan digunakan dalam proses perhitungan. Lankah selanjutnya, menentukan fungsi implikasi, lalu melakukan pengolahan data himpunan fuzzy dengan metode maksimum. Langkah terakhir yaitu proses defuzzyfikasi dengan metode centroid. sehingga akan diperoleh jumlah perencanaan produksi bulan berikutnya. Data yang digunakan adalah data 1 tahun jumlah produksi air mineral yang digunakan untuk proses perhitungan. Berdasarkan hasil Analisa sistem perencanaan jumlah produksi air mineral menggunakan metode fuzzy mamdani dapat diketahui jumlah produksi yang didapatkan dari hasil proses perhitungan akhir menggunakan defuzzyfikasi adalah 3785 dus.
INVESTIGASI EKSTRAK BAHAN ALAM SEBAGAI INHIBITOR KOROSI HIJAU PADA BAJA MENGGUNAKAN TEORI FUNGSIONAL KERAPATAN
Authors: Akrom Muhamad
Published: January 2022

Salah satu material yang ketahanannya terhadap korosi rendah adalah baja ketika berinteraksi dengan lingkungan korosif. Penggunaan green inhibitor mampu memberikan kinerja penghambatan korosi yang baik dengan efisiensi inhibisi yang tinggi pada baja.  Green inhibitor yang dalam struktur senyawanya mengandung gugus heteroatom (seperti O, N, S, P) dan cincin aromatik efisien digunakan sebagai inhibitor korosi pada baja. Makalah ini memberikan tinjauan komparatif penting bagi pengembangan green inhibitor ekstrak bahan alam pada baja. Kajian DFT pada level atomik berdasarkan orbital molekuler, parameter kuantum kimia, dan karakteristik adsorpsi menunjukkan hasil yang sesuai dengan hasil eksperimen. Distribusi kerapatan elektron melalui plot Frontier Molecular Orbitals (FMO) menggambarkan prediksi situs aktif melalui distribusi daerah HOMO-LUMO molekul inhibitor yang berinteraksi dengan permukaan baja. Untuk mendapatkan korelasi antara sifat elektronik molekul inhibitor dengan potensi penghambatan (inhibisi) korosi, kalkulasi parameter kimia kuantum seperti potensial ionisasi (I), afinitas elektron (A), kekerasan global (η), elektronegativitas absolut (χ), kelembutan global (σ), fraksi elektron yang ditransfer (ΔN), elektrofilisitas global (ɷ) dan donasi balik elektron (ΔEback-donation) menunjukkan reaktivitas molekul inhibitor yang berpotensi sangat baik untuk dapat berinteraksi dan berikatan kuat dengan permukaan logam, sehingga berpotensi menghasilkan efisiensi inhibisi yang tinggi. Mekanisme inhibisi korosi dapat melalui adsorpsi kimia dan/atau adsorpsi fisika dengan membentuk senyawa kompleks antara molekul inhibitor dengan permukaan baja untuk melindungi dari lingkungan korosif. Pengembangan kajian ke depan harus dapat menampilkan mekanisme interaksi dan inhibisi dari molekul inhibitor secara lebih detail dan sistematis pada level atomik pada beberapa permukaan logam seperti Fe, Al, Cu, dan lainnya.
Trastorno del espectro autista y cursos masivos abiertos en línea: Tratando de disminuir la brecha del acceso a la información
Authors: Barrios-Borjas Dayara , Bravo-Pino Karen
Published: January 2022

Señora Editora: El trastorno de espectro autista engloba a un grupo de trastornos del desarrollo neurológico que incluye al autismo, Sindrome de Asperger y trastornos generalizados no clasificados en otra parte, enfocándose como criterios diagnósticos el deterioro de interacción social, intereses restringidos y conductas repetitivas. Se estima que 1 de cada 36 niños lo padecen, con tendencia a incremento en las últimas décadas. Se ha evidenciado que tanto los pacientes con este trastorno y sus cuidadores, a menudo se enfrentan al estigma debido a estereotipos, conceptos erróneos y discriminación sobre su diagnóstico, ejercido por la sociedad dominante, sobre todo en entornos educativos y comunitarios.
Qué difícil concepto: El potencial de acción nervioso
Authors: Cortés Manuel E. , Llona Isabel , Alfaro-Silva Andrea A.
Published: January 2022

Señora Editora: La conducción de los impulsos nerviosos ha llamado la atención de los científicos por décadas. Éstos se generan gracias al desencadenamiento de un potencial de acción (PA), definido como una reversión transitoria en la polaridad del potencial de reposo de la membrana neuronal que se propaga a lo largo del axón desde su punto de inicio hasta los terminales axónicos, constituyendo así uno de los más fascinantes fenómenos biológicos.
Uso de la Escala de Inteligencia de Adultos de Wechsler-IV para la evaluación neuropsicológicas en Ecuador
Authors: Pluck Graham , Mayorga-Albán Amalín , Hernandez-Rodriguez José L. , Garcés María Sol , Bravo-Mancero Patricia
Published: January 2022

Una parte fundamental de la evaluación del estado cognitivo es la determinación de la capacidad cognitiva general. Sin embargo, las pruebas cognitivas más comunes no están estandarizadas para su uso en Ecuador. Esto ha limitado el alcance y la precisión de las evaluaciones clínicas neuropsicológicas en el país. Se aplicó la Escala de Inteligencia para Adultos de Wechsler-IV (WAIS-IV), de 7 subpruebas, a 155 adultos ecuatorianos de 4 ciudades del Ecuador, pertenecientes a distintos estatus socioeconómicos. La muestra se ajustó a la población urbana ecuatoriana en cuanto a género, educación y etnia. Se demostró que esta versión de la WAIS-IV es una evaluación fiable y válida para su uso en este contexto. Adicionalmente, los resultados proporcionan un método para ajustar las puntuaciones estándar derivadas de la población española, y utilizadas en el manual de la WAIS-IV, para que sean más apropiadas para su uso en Ecuador. Este método puede ser potencialmente utilizado para calcular las puntuaciones completas del coeficiente intelectual (CI). Por último, se describen métodos de comparación de las puntuaciones estándar ajustadas en Ecuador para que puedan ser utilizadas en evaluaciones clínicas neuropsicológicas de adultos ecuatorianos.
RENDEZVÉNYEKKEL A VIDÉK EGÉSZSÉGÉÉRT ÉS ÉLHETŐSÉGÉÉRT
Authors: Major Zsigmond
Published: January 2022

Az elmúlt évek során folyamatosan növekszik az egészséges életmóddal, az egészséggel, az ezekhez kapcsolódó magatartási formákkal kapcsolatos vizsgálatok száma, amelyek a mindennapi életre gyakorolt hatásukat is elemzik. Jelen cikk arra az igen tág kérdésre keresi a választ, hogy miként lehet növelni a jólétet és az életszínvonalat a vidéki területeken. A téma vidéki aspektusba történő helyezése kiemelt társadalmi jelentőséggel bír, mivel nemcsak az EU-ban, hazánkban is meghatározó részarányt képvisel a vidéki terület.