bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of different geometrical dimple configurations on flow behaviour and thermal performance within a 3D circular pipe
Authors: AL-OBAIDI Ahmed Ramadhan , ALHAMID Jassim
Published: February 2024

Numerical analysis has been performed to evaluate the heat transfer characteristics and per-formance of a circular pipe with geometrical dimple patterns. Using computational fluid dy-namics (CFD) codes, we examine the effects of geometrical configurations on the flow and thermal behavior of circular pipes with concavity (dimple) diameters. Fluid mixing and flow perturbation are facilitated by perforations across the pipe core and wall regions, thereby im-proving thermal efficiency. In addition, a concavity with a diameter of 4 mm enhances heat transfer. Based on the results of the study, the disrupted pipe wall and pipe core region pro-duce swirls and transverse vortices in the flow that provide superior heat transfer compared to conventional (smooth) pipes. In an increasing Reynolds number (Re), mixing, secondary, and separation flows become larger. Performance evaluation factor (PEF) values increased at low Reynolds numbers when dimple diameter was 1mm. As a result of these improved pipes, heat exchanger efficiency may improve in industrial applications, a key factor for energy con-servation.
Reading performance in school going children with visual function anomalies
Authors: Kadir Syeed Mehbub Ul , Sarkhel Sunanda , Chakraborty Sayantan , Maurya Rajendra Prakash , Akter Nilufa , Masihuzzaman  , Bhardwaj Gaurav Kumar , Khatun Mastura
Published: February 2024

To compare reading performance in children with and without visual function anomalies.

This cross-sectional study was carried out from May 2021 to April 2022 in a tertiary eye hospital of Bangladesh. This study included patients with 6-15 years of age who visited at Vision Therapy clinic. CISS-score was used to identify the asthenopia complaints and reading difficulties while having a normal vision and normal retinal function only selected for recruitment. Reading error, accuracy and reading speed were assessed with an N-notation chart with an N6 target size and the time taken to complete the task was recorded with a stopwatch. Both univariate and bivariate tables are used for analysis. Statistics analysis was performed accordingly, and the level of significance used was at 0.05.

Out of 200 subjects, 46.5% boys and 53.5% girls. Of the total, 15.5% had NVF. The mean age of the participants was 12.04 (±2.44) years. Children with AVF had a higher number of reading errors and non-significant negative correlation (AVF=7.64 (±5.19); NVF 6.55 (±3.67); (r = -1.00, p=0.157). Lower Reading accuracy was noted in AVF as correlated to NVF and non-significant negative correlation (AVF=86.11 (±14.84); NVF=86.43 (±13.12); (r= -0.008, p=0.912). Similarly, lower reading speed was noted in AVF as correlated to NVF and non-significant negative correlation (AVF=79.47 (±39.20) wpm; NVF=84.51±36.84 wpm; (r= -0.047, p=0.507). A statistically significant difference was seen between AVF and NVF (p=0.001 at a 95% Confidence Interval of the differences). Children in the 1 to 5 grades presented a higher risk of reading impairment than the 6 to 10grades. Higher reading speed (112±20.69wpm) was noted in 10 grade.

In this study, it was observed that poor reading performance is linked to abnormal visual function in school-aged children, but visual function and reading performance are not positively related.
Clinical outcome in patients with 4- point scleral fixated intraocular lens: Our experience
Authors: Divyalakshmi Kaiyoor Surya , Singh Chaithanya Blevender , Shambu Rashmi
Published: February 2024

Visual rehabilitation following cataract surgery with compromised capsular bag includes various options like anterior chamber (ACIOL), fixation to the iris (Iris claw IOL), or fixation to the sclera (SFIOL), as a primary or secondary procedure. We studied the clinical outcome in patients who underwent 4- point fixation of SFIOLs.

Retrospective data analysis of fourteen patients who underwent sclera fixated intraocular lens implantation from 2016 to 2018 at our institute under standard operative conditions was done.

The postoperative vision by three months ranged from LogMAR 1.0 – 0.2, out of fourteen patients, BCVA in 60 % of the patients ranged from LogMAR 0.3-0.2 which was maintained at six months follow up with minimal complications.

4- point fixation of scleral fixated IOL is a good option with favourable outcome, in aphakics who are not ideal candidates for iris claw lens.
A comparative study of central corneal thickness in patients with diabetes and without diabetes mellitus
Authors: N K Lessitha , A Haleema , Haneef Mohammed , Paul Shalet
Published: February 2024

Diabetes mellitus (DM) is becoming increasingly and seriously prevalent lifestyle health problem worldwide. Up to 70% of diabetic patients can develop corneal changes and are also difficult to manage. Several studies were done to find out the morphological changes in cornea in type 2 DM, but the results are highly variable. Central corneal thickness (CCT) is widely considered as a constant parameter, so are measured only once during follow up in our daily clinical practice. Here we study the effect of diabetes over CCT, for a better understanding of the impact of diabetes over CCT.

A comparative observational study of one and half years done among 106 diabetes and 106 non diabetic patients between 35 to 75 years old, attending ophthalmology OPD. CCT of both eyes was measured and mean CCT and was compared between diabetic and non-diabetic groups, among different subgroups of diabetic subjects and other parameters.

CCT was thicker among diabetic groups (553.4434um) than non-diabetic groups (549.8491) but was not statistically significant according to our study. But there was statistically significant (p value 0.000165) thickening with increasing grades of diabetic retinopathy (DR) (mild DR (535.4524), moderate DR (543) and PDR (591.5)).

Our study concludes that DM is associated with thicker cornea; hence CCT values can vary with time in DM. So repeated CCT measurements for corrected IOP values is advised and warranted in DM patients for proper management of IOP.
Fabrication of biodegradable nano medical patches incorporating a sustained-release pharmacological agent using electro-spinning technique
Authors: Shaikh Afroj Ayyaj , Anbhule Sachin Jalinder
Published: February 2024

Nano-polymer (self-disappearing) medical patches loaded with a long-acting drug (each substance separately) were created by electro-spinning synthetic polymers PVA and PVP at a rate of 10%W for each polymer and adding various medicinal substances, such as diclofenac de ethylamine and gentamicin, in concentrations of 5%w each. The morphological structure of the produced samples was further studied using a scanning electron microscope (SEM) and X-ray diffraction (XRD) before they were turned into a medical adhesive and tested directly on a human hand. This approach has already proven to be effective in delivering the medicine to the affected area without the use of any intermediaries. It is relatively simple to use, safe for medical usage, and inexpensive due to the lack of expensive industrial apparatus required for production.
Impact of FDI absorptive capacity on labor productivity in Vietnam
Authors: Hung Tran Khanh , Binh Dang Thai , Trang Tieu Van , Hoa Hoang Van , Anh Do Quynh , Tu Pham Huy
Published: February 2024

This study examines the impact of Foreign Direct Investment (FDI) absorptive capacity on labor productivity in Vietnam's vibrant and dynamic context. Using panel data analysis of firm-level data from the Vietnam Enterprise Survey for 2008-2018, which was collected by the General Statistics Office of Vietnam, the authors find out that capacity is essential in enhancing labor productivity in Vietnamese firms. The study takes a strong and thorough approach, using panel data analysis to find out the many aspects of firm-level absorptive capacity and what these aspects mean for improving labor productivity in Vietnamese businesses. Specifically, firms with higher absorptive capacity tend to have higher labor productivity levels than those with lower absorptive capacity. Our findings suggest that policy makers in Vietnam and other developing countries must develop their absorptive capacity to benefit from FDI and fully improve productivity. In order to fully benefit from foreign direct investment (FDI), host nations must place a high priority on building their capacity to absorb FDI through wise expenditures in infrastructure, innovation, education, and training, as well as intellectual property rights protection. The study also shows how important absorptive capacity is in the relationship between FDI and productivity by adding to the existing research and finding the specific absorptive capacity indicators that are most useful for increasing labor productivity in Vietnamese businesses.
A noção de “risco normal” nas opções de venda relacionadas a investimentos no setor energético
Authors: Martins-Costa Judith
Published: February 2024

O artigo tem como objetivo, por meio de uma metodologia funcional, examinar os riscos envolvidos nas opções de venda relacionadas a investimentos no setor de energia, que possui diversas peculiaridades. O estudo consiste em delimitar quais riscos estão ou não dentro do escopo normal do contrato. A opção é examinada sob uma perspectiva funcional: se sua função é puramente especulativa ou se seu objetivo é retirar um dos sócios. Considerando os riscos que excedem a faixa normal (alea normal), examina-se a possibilidade de revisão ou rescisão contratual, analisando os requisitos legais contidos nos artigos 317, 478 e 480 do Código Civil Brasileiro.
La distinción entre la estafa y el incumplimiento contractual. Sobre la relevancia penal del engaño en los contratos
Authors: Pariona Arana Raúl
Published: February 2024

Los contratos son un elemento clave en el sostenimiento del sistema económico actual. No obstante, las partes obran en ocasiones con la intención de defraudar y perjudicar la relación contractual. Una de las conductas más frecuentes en donde se manifiesta la voluntad defraudatoria es en la utilización de medios fraudulentos, orientados a engañar a la contraparte, para celebrar el contrato y luego incumplir la prestación pactada. Esto ha generado la previsión de mecanismos de tutela y sanción de carácter civil y penal. En ese sentido las figuras que se han venido aplicando en la praxis son la estafa contractual, el dolo como vicio de la voluntad y el incumplimiento contractual. Pese a la similitud entre estas figuras, resulta de suma relevancia su distinción atendiendo a que la consecuencia del delito de estafa es una pena privativa de la libertad. En ese contexto, el trabajo presenta las figuras legales que tutelan las relaciones contractuales frente a comportamientos donde media el engaño y aborda el análisis de los criterios de delimitación entre el delito de estafa y las instituciones civiles.
Towards an Integrated Information System for a Higher Education Institution Volunteering Group
Authors: Ramires Piedade , Pardal Ana , Godinho Maria
Published: February 2024

This paper describes the first few steps given towards the construction of an Integrated Information System for a Higher Education Institution Volunteering Group. With that purpose, the problem is characterized, requirements are gathered, and the prototype design discussed. Finally, a set of conclusions is presented and direction for future work pointed out.
Perception de la Sanction, Perception de la Justice Sociale et Attitude a l’Egard du Paiement de l’Impot chez les Cefs de Menage d’Abidjan (Cote d’Ivoire)
Authors: Albert Thierry Djako Logon , Lokotianwa Sali Kone Née Yeo
Published: February 2024

En dépit de l’importance indéniable des recettes fiscales dans la constitution du budget de l’Etat et, par conséquent, pour le financement des projets d’utilité publique, un nombre de plus en plus élevé de contribuables en Côte d’Ivoire refusent de payer l’impôt en dissimulant leurs biens ou en les déclarant partiellement. La présente étude tente de comprendre cette situation en examinant l’incidence de la perception de la sanction encourue pour fraude ou évasion fiscale et de la perception de la justice sociale sur l’attitude à l’égard du paiement de l’impôt chez les chefs de ménage d’Abidjan. L’enquête porte sur un échantillon représentatif de 350 participants recrutés selon la technique de l’échantillonnage par quota. Les données sont recueillies grâce à un questionnaire et traitées à l’aide du test du « t de Student ». Les résultats obtenus corroborent nos hypothèses. D’une part, les chefs de ménage qui sous-estiment la sanction qu’ils encourent pour fraude ou évasion fiscale sont moins favorables au paiement de l’impôt que ceux qui surévaluent cette sanction. D’autre part, les chefs de ménage percevant une injustice sociale sont moins favorables au paiement de l’impôt que leurs pairs percevant une justice sociale. Ces résultats pourraient aider à l’élaboration de stratégies de sensibilisation plus efficaces pour favoriser la conformité fiscale volontaire.

 

Despite the undeniable importance of tax revenues in the constitution of the state budget and, consequently, for the financing of public utility projects, an increasing number of taxpayers in Côte d'Ivoire refuse to pay tax by concealing their property or by partially declaring it. This study attempts to understand this situation by examining the impact of the perception of the penalty incurred for tax evasion or fraud and the perception of social justice on the attitude towards paying tax among heads of households in Abidjan. The survey is based on a representative sample of 350 participants recruited using the quota sampling technique. The data are collected through a questionnaire and processed using Student's t-test. The results obtained corroborate our hypotheses. On the one hand, the heads of households who underestimate the penalty they incur for tax fraud or evasion are less favorable to paying the tax than those who overestimate this penalty. On the other hand, the heads of households perceiving a social injustice are less favorable to the payment of taxes than their peers perceiving a social justice. These results may help in the development of more effective awareness-raising strategies to encourage voluntary tax compliance.
Identifying Areas of High Gold Potential Using Geochemical Prospecting Methods: The Tenado Area in the Boromo Birimian Belt, West-Central Burkina Faso, West Africa
Authors: Tarnagda Aziz Fayçal , Ouiya Pascal , Sawadogo Saga
Published: February 2024

The investigation area is located in the central-western region of Burkina Faso, in a geological environment that incorporates the Paleoproterozoic formations of the Boromo greenstone belt. This zone already has several gold showings and an active zinc mine, but no major gold deposits. The aim of this study is to define target areas with high gold potential for further prospecting. To meet this objective, we mainly used total rock geochemistry and stream sediment geochemistry methods. The combination of stream sediment gold content and litho-geochemical data has enabled us to highlight two areas of gold (Au) and various metal anomalies. The gold content of stream sediments is mainly influenced by that of the parent rock from which they are derived. In fact, strong gold anomalies are more common in clay sediments than in sandy sediments. These clay sediments are derived from basic rocks (basalt) and intermediate rocks (andesite-dacite), while the gold-poor sandy sediments are derived from granitoids. Basic to intermediate rocks are fertile for primary gold. Anomaly zone one (01) in the northern part of the study area (Kelsio, Zoula, Poa and Dyoro) and anomaly zone two (02) in the southern part of the study area (Kwademan, Baguiomo, Bérédo, Bonga and Baganapou) show occurrences of mainly gold and various metals (Zn, Cu, Ni).
Détermination du Niveau de Contamination en Métaux Lourds (Arsenic, Cadmium, Mercure et Plomb) de Quatre Espèces de Poissons Consommées par les Familles de Pêcheurs de Jacqueville
Authors: N’Doua Alex Diane Y. S. , Adjessan Magha Ayi M. N. , Koffi Kouamé Mathias
Published: February 2024

L’objectif de cette étude était de déterminer le niveau de contamination des éléments traces métalliques (ETM) toxiques (arsenic, cadmium, mercure et plomb) dans des poissons consommés par les familles des pécheurs de Jacqueville, et ce dans le cadre d’une évaluation des risques chimiques liés à la consommation de poissons. Pour ce faire, 72 échantillons de poissons prélevés auprès de 81 foyers enquêtés et repartis entre 4 espèces, ont été analysés par spectrophotométrie d’absorption atomique. Il ressort que les traces des différents métaux existent dans les muscles (chairs) à des taux variables avec un dépassement des critères de comestibilité au niveau de l’arsenic et du cadmium. D’une part, Selene dorsalis avec 1,26 mg/kg, Sarotherodon melanotheron avec 1,33 mg/kg et Chrysichthys avec 1,27 mg/kg sont les poissons les plus contaminés en arsenic. D’autre part, Selene dorsalis avec 0,063 mg/kg et Sardina pilchardus avec 0,054 mg/kg présentent des niveaux de contamination cadmique élevés. Ces valeurs sont supérieures à la limite autorisée (0,05). Le risque pour ces consommateurs peut être réel du fait du caractère cumulatif lié à la toxicité de ces métaux, si les quantités consommées sont élevées.

 

The purpose of this study was to determine the level of contamination of toxic trace metal elements (TME) (arsenic, cadmium, mercury, and lead) in fish consumed by the families of Jacqueville fishermen, as part of an assessment of chemical risks associated with fish consumption. To do this, 72 fish samples taken from 81 households surveyed and divided between 4 species, were analyzed by atomic absorption spectrophotometry. It appears that traces of different metals exist in the muscles (flesh) at variable levels with edibility criteria exceeded in terms of arsenic and cadmium. On the one hand, Selene dorsalis with 1.26 mg/kg, Sarotherodon melanotheron with 1.33 mg/kg and Chrysichthys with 1.27 mg/kg are the fish most contaminated with arsenic. On the other hand, Selene dorsalis with 0.063 mg/kg and Sardina pilchardus with 0.054 mg/kg present high levels of cadmium contamination. These values are greater than the authorized limit (0.05). The risk for these consumers can be real due to the cumulative nature linked to the toxicity of these metals if the quantities consumed are high.
Phenylpropanoids as a class of natural biologically active organo-protective compounds
Authors: Kurkin V. A. , Varina N. R. , Avdeeva E. V. , Ruzaeva I. V.
Published: February 2024

The aimof the work wasto analyze the current research state of phenylpropanoids as a special specific class of biologically active compounds and the prospects for their use for the development of medicines and biologically active food additives.

Materials and methods.The scientific data for the period from 1968 to 2023 were studied in the databases of Scopus, ScienceDirect, PubMed, Google Scholar, e-library.ru, ResearchGate – a scientific information network. Herewith, the following keywords were used: “phenylpropanoids”, “antioxidants”, “hepatoprotectors”, “immunomodulators”, “organoprotectors”, “anxiolytics”, “adaptogens”, “preventive medicine”, “sanogenesis”, “medicines”, “biologically active food additives”, “sports medicine” and their English-language analogues.

Results.This scientific research examines the main stages and results of studying the class of phenylpropanoids in the following aspects: a chemical structure and classification, biosynthesis and its role in the biogenesis of other classes of phenolic compounds, their distribution, biological and pharmacological activity in the plant world, the search for plant sources and their use in medicine and pharmacy. The existing and potential applications of phenylpropanoids for preventive and therapeutic purposes are discussed.

Conclusion.The analysis of the scientific publications on the pharmacognostic and biomedical studies of the medicinal plants containing phenylpropanoids, substantiates the expediency of considering them as an autonomous specific class of biologically active compounds. The organoprotective profile of their action and a wide range of specific pharmacological activities of phenylpropanoids are connected by common links of the sanogenesis in the “prooxidant–antioxidant” system. The choosing of promising plant sources for the development of medicines and biologically active compounds with specified properties is justified from the dependence position of “chemical composition – structure of compounds – spectrum of activity”.
Review of publications on drug-related problems investigations in osteoporosis patients
Authors: Egorova E. A. , Beitullaev A. M. , Matveev A. V. , Koryanova K. N.
Published: February 2024

A chronic form of osteoporosis (OP) substantiates a long-term pharmacotherapy of patients, which increases the risk of adverse drug reactions (ADRs) during the therapy. The enhancement of requirements to the quality of safety monitoring carried out in the context of pharmacovigilance and the newly identified safety problems require an improvement of the system of quality control of medicinal products (MPs).

The aim of the work was to review the application of a new promising method for monitoring the drug safety – the system of Drug-Related Problems (DRP) in the osteoporosis pharmacotherapy.

Materials and methods. The following databases and search engines were used to retrieve scientific papers by Russian and foreign authors: PubMed, elibrary.ru, Google Scholar, CyberLeninka, Russian National Library. The information sources were searched using the following keywords and word combinations: “drug-related problems”, “drug safety”, “osteoporosis” (in Russian and English, respectively), as well as the corresponding MeSH terms.

Results. The application of DRP system in the health care of different countries was reviewed, and the risk factors of the problems associated with the use of MPs, the appropriate interventions in case of the detection of high DRP values were investigated. The study of the problems associated with the use of MPs for the treatment of OP during the complex pharmacotherapy made it possible to determine the feasibility of using this method to improve the safety and effectiveness of this kind of treatment in patients.

Conclusion. The analysis of emerging DRPs makes it possible to increase patients’ adherence to the treatment and stop the ADRs. This improves the quality of life of patients and increases the effectiveness of pharmacotherapy. The introduction of such a method of the drug safety research into the system of pharmacovigilance of the Russian Federation is an important step in the development of personalized medicine. A further study of problems associated with the use of drugs in OP patients will also help to reduce the risks arising during the combination pharmacotherapy.
Los desafíos al discurso de los derechos humanos tras 50 números de Derechos y Libertades
Authors: Barranco Avilés María del Carmen
Published: February 2024

La autora se pregunta por la medida en que los problemas que se identificaban como actuales en el primer número de Derechos y Libertades se mantienen como desafíos al discurso de los derechos humanos. La conclusión a la que llega es que todavía hoy es necesario discutir sobre la universalidad, la participación,las desigualdades, la degradación de los derechos sociales, el papel de los derechos en las relaciones internacionales y el medio ambiente. Además, a los anteriores, se suman la amenaza del terrorismo y la respuesta a esta amenaza, así como el auge de los populismos de extrema derecha, y el impacto de la revolución tecnológica.En la actualidad, un contexto marcado por el Antropoceno, el cambio climático y el impacto de las nuevas tecnologías convierte en perentorio el discurso de los derechos y, sobre todo, la extensión de este más allá de los entornos académicos a través de la educación en derechos.
Derechos humanos
Authors: Squella Agustín
Published: February 2024

Este artículo examina la compleja relación entre democracia y derechos fundamentales, argumentando que una perspectiva histórica de los derechos, que es indispensable, no necesariamente justifica su existencia en términos historicistas. Señala que la expansión y generalización de los derechos han planteado desafíospara definir un concepto unificado de derechos fundamentales. Además, critica la percepción romántica de que la democracia es suficiente para garantizar estos derechos, especialmente en un contexto de crisis de representación, corrupción y otros desafíos contemporáneos.

El artículo también aborda la disyuntiva entre democracia y capitalismo, especialmente en su forma neoliberal, argumentando que esta alianza ha sido problemática y ha contribuido a la erosión de los derechos sociales. Se destaca que, aunque las democracias pueden violar los derechos humanos, estas violaciones no son sistemáticas y hay mecanismos para denunciarlas y corregirlas. El autor sugiere que para entender los desafíos actuales en el discurso de los derechos, es crucial considerar su historia desde la Modernidad hasta el presente.
Gregorio Peces-Barba y Norberto Bobbio
Authors: Losano Mario G.
Published: February 2024

Los intereses científicos y políticos de los filósofos del derecho Gregorio Peces-Barba (1938-2012) y Norberto Bobbio (1909-2004) se reflejan en más de 70 cartas escritas entre 1978 y 2004, es decir, en los años en que en España entró en vigor la nueva Constitución democrática. Un tema recurrente de esta correspondenciaes el diferente enfoque, en ambos países, de la coexistencia entre socialismo y democracia, así como con el comunismo y el eurocomunismo. El resultado es un vivo retrato de la relación de Bobbio con los políticos españoles. El presente ensayo incluye también algunas frases de relevancia seminal extraídas de las cartas de cada uno de los dos, así como las palabras de Peces-Barba conmemorando la muerte de Bobbio en la prensa española: palabras que atestiguan no sólo la afinidad política, sino también el afecto personal de ambos eruditos.
La lógica carceralista y la lucha por los derechos
Authors: Bernuz Beneitez María José
Published: February 2024

En la última década se ha podido apreciar cómo algunos colectivos sociales, heterogéneos entre sí, exigen y celebran las penas de cárcel cuanto más largas mejor ante delitos que atentan contra los bienes y valores que defienden. En este trabajo se trata de reflexionar sobre la paradoja que supone que movimientosque se implican en la lucha por la evolución y consolidación de los derechos fundamentales, denuncien la crueldad y disfunciones que genera el sistema penal en general y la cárcel en particular, pero los justifiquen como medios adecuados para poder visibilizar, responder y resolver problemas sociales. Son incoherenciasque pueden alimentar e incrementar la pendiente deslizante hacia el excepcionalismo punitivo y carcelario y que consolidan otro tipo de populismo punitivo.
Thomas Casadei - Gianfrancesco Zanetti, Manual de Filosofía del Derecho. Figuras, categorías, contextos
Authors: Ramis Barceló Rafael
Published: February 2024

Este artículo reseña: Thomas CASADEI - Gianfrancesco ZANETTI, Manual de Filosofía del Derecho. Figuras, categorías, contextos, Prefacio y traducción de Fernando H. Llano Alonso, Madrid, Tecnos, 2023, 504 pp.
Resposta a “Risco Nutricional e Desnutrição em Pediatria: Da Avaliação Antropométrica à Ferramenta de Rastreio STRONGkids®”
Authors: Isaac Nélia , Dutschke Vera , Amorim João , Partidário Marta , Rito Sofia
Published: February 2024

N/D.
Cancer-associated fibroblasts (CAFs) based model reveals potential for predicting bladder cancer patients’ prognoses and immunotherapy responses
Authors: Dong Mengyuan , Zhang Xu
Published: February 2024

Aim: The purpose of this study is to enhance the understanding of bladder cancer and the role of cancer-associated fibroblasts (CAFs) in its progression. We aim to identify CAF-specific biomarkers and develop a prognostic prediction model based on CAFs, thereby contributing to the advancement of treatment strategies and the identification of prognostic and predictive biomarkers for bladder cancer.

Method: We employed single-cell RNA sequencing to detect biomarkers for CAFs in bladder cancer cells. Bladder cancer cohorts were categorized into low- and high-CAF groups using the ssGSEA algorithm. The study also explored the association between CAF-related scores, immune-related cells, and immune checkpoint-related genes. Furthermore, we performed GSVA analysis to understand the biological features of CAFs and their link to various cancer-related pathways.

Result: Ten genes were identified as CAF markers in bladder cancer cells. A significant difference was found with 2712 differentially expressed genes between low-CAF and high-CAF tissues. The CAFs-based prognostic prediction model included nine genes (ALDH1L2, AL450384.2, EMP1, LINC02362, WFIKKN1, GOLGA8A, POU5F1, AL354919.2, PTPRR), which are potentially crucial in predicting bladder cancer prognosis. The GSVA analysis revealed the involvement of several cancer-related pathways, such as WNT, toll-like receptor, TGF-beta, MAPK, and MTOR signaling pathways, in the CAFs-based prognostic model.

Conclusion: This study highlights the significant role of CAFs in the progression and prognosis of bladder cancer. The identified CAF biomarkers and the constructed prognostic model provide valuable insights for future research and potential therapeutic targets. CAF-dependent pathways are promising for the development of new treatments and improving the prognosis of bladder cancer patients.
Extracellular vesicles: the key to unlocking mechanisms of age-related vascular disease?
Authors: Whitehead Meredith , Antonazzi Marco , Shanahan Catherine M.
Published: February 2024

Aging is associated with the development of two ubiquitous, detrimental pathologies, vascular calcification and amyloidosis. These pathologies are characterized by the accumulation of toxic aggregates in the vessel extracellular matrix (ECM) in the form of crystalline calcium and phosphate mineral or insoluble protein fibrils, respectively. These aggregates impact ECM integrity, drive vascular stiffening, and can also cause cell death and phenotypic change in the cells that interact with them. The deposition of both calcification and amyloid requires a nucleus that can mediate the mineralization of calcium and phosphate, or amyloid aggregation from precursor proteins or peptides. Emerging evidence suggests that changes in the composition of the ECM associated with cellular senescence, as well as extracellular vesicle (EV) release, cargo-loading, trapping, and aggregation within the ECM, are common and synergistic mechanisms that regulate the development of these pathologies. Importantly, vascular smooth muscle cells (VSMCs) orchestrate the formation of both pathologies that commonly co-occur in the aging vasculature. Here, we outline the commonalities and differences in what is known about the genesis of calcification and amyloid, and highlight key questions and areas that remain unknown and require further investigation. The complex relationship between senescence, EVs, and the ECM, mediated by VSMCs, which drives the accumulation of HA and amyloid, could be a target for therapeutic intervention.
Distributed Jacobi-Proximal ADMM for Consensus Convex Optimization
Authors: Xiao Xian-Hong , Deng Hui , Xu Yang-Dong
Published: February 2024

In this paper, a distributed algorithm is proposed to solve a consensus convex optimization problem. It is a Jacobi-proximal alternating direction method of multipliers with a damping parameter $\gamma$ in the iteration of multiplier. Compared with existing algorithms, it has the following nice properties: (1) The restriction on proximal matrix is relaxed substantively, thus alleviating the weight of the proximal term. Therefore, the algorithm has a faster convergence speed. (2) The convergence analysis of the algorithm is established for any damping parameter $\gamma\in(0,2]$, which is larger ones in the literature. In addition, some numerical experiments and an application to a logistic regression problem are provided to validate the effectiveness and the characteristics of the proposed algorithm.
Advances in Aeroengine Cooling Hole Measurement: A Comprehensive Review
Authors: Yan Shuyan , Shi Junkai , Li Guannan , Hao Can , Wang Ying , Yu Hao , Zhou Weihu
Published: February 2024

Film cooling technology is of great significance to enhance the performance of aero-engines and extend service life. With the increasing requirements for film cooling efficiency, researchers and engineers have carried out a lot of work on the precision and digital measurement of cooling holes. Based on the above, this paper outlines the importance and principles of film cooling technology, reviews the evolution of cooling holes. Also, this paper details the traditional measurement methods of the cooling hole used in current engineering scenarios with their limitations and categorizes digital measurement methods into five main types, including probing measurement technology, optical measurement technology, infrared imaging technology, computer tomography(CT) scanning technology, and composite measurement technology. The five types of methods and integrated automated measurement platforms are also analyzed. Finally, through a generalize and analysis of cooling hole measurement methods, this paper points out technical challenges and future trends, providing a reference and guidance for forward researches.
Hesitant Fuzzy Entropy Analysis for Food Security Assessment and Correlation with Integrated Phase Classification: Evidence from Sudan
Authors: Fadol Ahmed A.A. , Tong Guangji , Erokhin Vasilii , Sikandar Furqan , Eissa Abdelazim , Raza Ali , Mohamed Wlaa
Published: February 2024

This paper provides a comprehensive analysis of food security in Sudan by adopting a unique approach of Hesitant Fuzzy Entropy (HFE) analysis to discern the key determinants influencing food security levels and aligning the findings with the Integrated Food Security Phase Classification (IPC) framework. The research utilized a dataset comprising 32 crucial variables related to food security assessment. Employing entropy values, weight coefficients, heatmaps, and scatterplots, the analysis aimed to unravel the intricate distribution of food security levels among Sudanese individuals in our study area. The study reveals that approximately 26% of the Sudanese population in our study region is poised to experience food security, with an additional 24% categorized as marginally food secure. Moreover, an estimated 35% are expected to confront moderate food insecurity, while 15% are projected to face severe food insecurity between January and June 2024. Anticipations for the period from January 2024 to June 2024 project more than 15 million individuals to encounter IPC Phase 3 and fall under moderately or severely food insecure levels. These findings emphasize the urgent need for both short-term humanitarian aid and long-term strategies to address Sudan's deepening food insecurity crisis.
Research on methods for modifying membership functions of fuzzy sets based on pattern
Authors: Barchev Nikolay Borisovich , Sudakov Vladimir Anatolievich
Published: February 2024

Fuzzy set membership functions are widely used to reflect expert preferences in situations of uncertainty. Procedures for modifying membership functions provide the opportunity to obtain new functions based on existing ones without the additional involvement of experts. The work examines existing and proposes new approaches to the construction of modification procedures, methods for their implementation and compensation for the difficulties arising in this case.
Az oktatásnyelvészeti kutatások sokszínűsége. Beszámoló a PeLiKon 2023 – A nyelv megújuló szerepe az oktatásban című konferenciáról
Authors: Bús Ágnes
Published: February 2024

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Meseintervenciós vizsgálat konduktív nevelésben részesülő atipikus fejlődésmenetű gyermekek körében
Authors: Pintér Henriett , Gál Franciska
Published: February 2024

Több hazai tanulmány foglalkozott a precízen kiválasztott és jól felépített mesék feldolgozásának az eredményességével tipikus fejlődésmenetű óvodások körében. Ugyanakkor elenyésző számban születtek hazai kutatások az atipikus fejlődésmenetű gyermekek számára kidolgozott meseintervenciók hatásairól. A jelen tanulmány egy több éve folytatódó, atipikus fejlődésmenetű gyermekek körében alkalmazott meseintervenciós kísérletet mutat be, valamint az ebben alkalmazott mérősor érvényességének és megbízhatóságának az eredményeit ismerteti. A meseintervenciós kísérlet öt alkalommal zajlott le három, atipikus fejlődésmenetű, konduktív nevelésben részesülő gyermek körében. Öt ítéletalkotásra átdolgozott mesében kellett a gyermekeknek igaz-hamis megállapításokat tenniük. A jegyzőkönyvek és a videófelvételek alapján végzett tartalomelemzés eredményei szerint a gyermekek válaszvariációinak rögzítésére alkalmasnak bizonyult a kidolgozott mérősor. A vizsgálat hozzájárulhat a bizonyítékalapú gyakorlat intervenciós lehetőségeinek a használatához, amelyet kis létszámú gyermekcsoport körében lehet megvalósítani.
A fogalmazásalkotás folyamatának vizsgálati lehetőségei
Authors: Gyenei Kornélia
Published: February 2024

Fontos lehet a későbbi életükben, hogy a középiskolás tanulók hogyan képesek adott idő alatt megfogalmazni különböző szövegeket. Ha a fogalmazások megalkotásának a részleteit folyamatában vizsgáljuk, hozzájárulhat ahhoz, hogy a diákok szövegalkotási készségét hatékonyabban fejleszthessük. A jelen pilotkutatás feltáró vizsgálat, célja egy olyan módszer tesztelése, amely az írott szöveg produkcióját folyamatában követi nyomon. A kutatás tíz fő tizenegyedik évfolyamos középiskolás gép előtt végzett fogalmazásalkotását vizsgálta. Ezt a műveletet a tanulók képernyővideó segítségével rögzítették, így a szövegprodukció során tartott gondolkodási szünetek is tetten érhetők. A középiskolás adatközlők a fogalmazásalkotás során közel egyforma mértékben tartottak szüneteket az alacsonyabb, illetve a magasabb kognitív terhelést igénylő műveletek elvégzésekor. A pilotkutatás eredményei azt mutatják, hogy indokolt a középiskolások fogalmazásalkotását fejleszteni.
Az anyanyelv és a matematika kapcsolódásának a lehetőségei
Authors: Bereczki Ildikó
Published: February 2024

Az anyanyelvi készségek meghatározóak más tantárgyak tanulásában, a tanulók tanulási eredményességében. A matematikában is kiemelt szerepe van a szövegértésnek a szöveges matematikai feladatok megoldásában. A tanulmány témája a szövegértés és a matematika kapcsolatának a vizsgálata. Az első rész a témakör elméleti hátterét taglalja, a szöveges matematikai feladatokra vonatkozó kutatások eredményeiből idéz. Ezek alapján olyan modellt mutat be, amely a feladatmegoldás stratégiáit írja le, és megadja a sikeres feladatmegoldás feltételeit, közöttük a szövegértés szerepét. A tanulmány következő része a matematika és az anyanyelvi fejlesztés kapcsolatának az attitűdformáló hatásával foglalkozik. A záró rész olyan feladatokat ajánl, amelyek megoldásához matematikai és anyanyelvi készségek egyaránt szükségesek. Példákkal szemléltet olyan komplex matematikai és szövegértési feladatokat, amelyek pozitívan hatnak a tanulók tantárgyakkal kapcsolatos attitűdjére és tanulási eredményére.
Nagy-Varga Zsolt: Kommunikációfejlesztés középiskolás diákok körében. Definícióalkotási stratégiák (P. Tóth Teodóra)
Authors: P. Tóth Teodóra
Published: February 2024

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Anat Stavans – Ulrike Jessner-Schmid (eds.): The Cambridge Handbook of Childhood Multilingualism (Fürész-Mayernik Melinda)
Authors: Fürész-Mayernik Melinda
Published: February 2024

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A Pedagogical Linguistics folyóirat
Authors: Imrényi András
Published: February 2024

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Effect of Beef Treatment at Different Temperatures on Myoglobin Changes : A Brief Review
Authors: Izzah Alya Nurul , Nurtiana Winda , Ningrum Marwah Astria , Anggraeni Sherly , Nugroho Insaan , Hasanah As Shifa , Alfidah Rahma , Febriyani Rosa
Published: February 2024

Myoglobin is the most important protein in the human and animal bodies, because myoglobin has a very important role in storing and transporting oxygen in muscle cells and giving meat its characteristic color. Each treatment used at different temperatures will have different changes. Meat storage treatments at different temperatures can have an effect on. The temperature methods used include room temperature, high temperature, low temperature and thawing. The color of the meat will change due to the interaction between myoglobin and oxygen which will form metmyoglobin after protein denaturation, so that it can change the color of the meat from reddish to brown and unattractive. When storing meat, it must be well controlled starting from air conditions and humidity so that it can maintain the red color of the meat. Apart from that, storage conditions and temperature control play an important role in storing meat, so that the quality of the meat lasts longer.
Fighting the BIPOC Awarding Gap: Decolonising Translation in Higher Education
Authors: Oaknin Mazal , Bolanos García-Escribano Alejandro , Navarrete Marga
Published: February 2024

This article reports on a project entitled “Tackling the BIPOC Awarding Gap” (2022–2025), whose aim is to foster teacher training practices that enhance diversity in language learning environments and tackle the awarding gap experienced by BAME (Black, Asian and Minority Ethnic) aka BIPOC (Black, Indigenous and People of Colour) students. According to Advance HE (2021), the difficulties experienced by BAME-BIPOC students to achieve higher marks remain a patent reality in most of today’s higher-education institutions in the UK. This paper describes how our collaborative project endeavours to tackle the BAME-BIPOC awarding gap from four main angles: 1) student-teacher collaboration; 2) teacher training; 3) redevelopment and decolonisation of practical translation syllabi; and 4) the establishment of a support network. In this paper, the focus is put on the main challenges, lessons learnt and examples of best practices stemming from the first year of this project.
“Para não deixar o céu cair”
Authors: Braga Alves Jucimara , Roberto Kirchof Edgar
Published: February 2024

Este artículo presenta un análisis de la obra del artista brasileño Denilson Baniwa y se centra en la forma en que las cosmogonías indígenas del norte de Brasil están representadas en su obra. El marco teórico que sustenta los análisis se basa en estudios poscoloniales y estudios antropológicos sobre las culturas de los pueblos indígenas brasileños, especialmente estudios centrados en sus cosmogonías. En la primera sección, presentamos una breve biografía de Denilson Baniwa, con énfasis en su participación en el movimiento artístico indígena brasileño contemporáneo. En la segunda sección, se discuten los principales conceptos teóricos movilizados en los análisis; a saber, cosmopolítica y perspectivismo. A continuación, se analizan algunas de las obras artísticas de Denilson, que se centran en las cosmogonías baniwa y, de esta manera, rescatan la memoria y los conocimientos ancestrales de los pueblos originarios de Brasil.
Mujeres como territorio de despojo: extractivismo, femicidios y violencia de género en el norte de Chile
Authors: Ibacache-Corante Andrea
Published: February 2024

This text explores different socio-historical and theoretical contents that shape the current experiences of women who live in the territories of what is known today as the north of Chile. The objective is to contribute to the theoretical approach in the analysis of social and gender inequalities in a context marked by mining extractivism and the vulnerability of its inhabitants. From a gender perspective, we analyze extractivism in the area and its consequences beyond environmental issues. The main conclusion is that the intersection of the issues addressed requires complex analyses where they can converge to strengthen the fusion of issues with a denouncing and innovative perspective.
Prevalencia y factores asociados al sobrepeso y obesidad en niños y niñas menores de 5 años, ENDES 2019
Authors:   , Abusabal Olcese Amira
Published: February 2024

Objetivo: Determinar la prevalencia y analizar los factores asociados al sobrepeso y obesidad en niños y niñas menores de 5 años según la ENDES 2019. Materiales y métodos: Estudio analítico secundario de tipo transversal de la ENDES 2019. Se realizó un análisis exploratorio (para las variables cuantitativas se sacó media, valores mínimos y máximos, y desviación estándar; mientras que para las variables cualitativas frecuencia relativa y absoluta), así como una medición de la asociación de las variables mediante el coeficiente de gamma, coeficiente phi o coeficiente D de Cohen según corresponda. Finalmente, se realizó un análisis multivariado de regresión logística binomial para evaluar la significancia de las variables y se utilizó el coeficiente de determinación para medir la fuerza de asociación multivariada. Resultados: La prevalencia de sobrepeso y obesidad en niños menores de cinco años fue de 6,31%. Las siguientes categorías estuvieron altamente asociadas a la existencia de sobrepeso y obesidad en menores de cinco años: características sociodemográficas, características del niño, y prácticas de lactancia y alimentación del niño. La categoría de características de la madre estuvo medianamente asociada y la categoría de consejería nutricional levemente asociada. Solo se encontró asociación con una de las variables de la categoría de violencia hacia la mujer. No hubo asociación entre el nivel de anemia con la presencia de sobrepeso y obesidad en menores de cinco años. Conclusiones: La prevalencia de sobrepeso y obesidad en niños menores de cinco años fue de 6.31%. Los factores altamente asociados a la presencia de sobrepeso y obesidad en niños fueron las características sociodemográficas (área de residencia e índice de riqueza), las prácticas de lactancia y alimentación del niño (duración de la lactancia materna y práctica de la lactancia materna exclusiva durante los primeros 6 meses), y las características del niño (edad y peso al nacer).
Causales para levantar la inmunidad presidencial: análisis del artículo 117 de la Constitución peruana
Authors:   , Beraun Lizarraga Claudia Mishell , Zambrano Chuquimango Lessly Dalila
Published: February 2024

La presente investigación tiene por objetivo analizar las causales existentes para levantar la inmunidad presidencial y sí estas contribuyen a que los procesos judiciales sean efectivos y oportunos después de culminado el Procedimiento de Acusación Constitucional. Lo importante de la investigación radica en la lista cerrada de las causales que contempla el artículo 117 de la Constitución; además, esclarecer las consecuencias jurídicas y políticas que tiene la inmunidad presidencial en el Perú. Para ello, realizamos una investigación cualitativa al comparar casos de la inmunidad parlamentaria, ya eliminada en el país, y la inmunidad presidencial, aún vigente. Así mismo, empleamos materiales y metodología de investigación histórica, comparada y deductiva al desarrollar casos emblemáticos de parlamentarios que han desnaturalizado la institución de la inmunidad, así como expresidentes que en la mayoría de los casos luego de su mandato son investigados judicialmente. En ese sentido, la investigación dio como resultado que en los últimos años, la inmunidad presidencial ha ido deteriorando su finalidad, lo que nos permitió concluir que las causales actuales son idóneas, pero no efectivas para abarcar los diversos tipos de acusaciones a la que el presidente se ve involucrado. Los hechos analizados en la presente investigación sirven como argumentos válidos para incluir como causales para levantar la inmunidad presidencial en determinados delitos, en base de los indicios presentados por la presunta comisión de delitos que afecten la seguridad nacional y la administración pública.