bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrative Approaches to Abiotic Stress Management in Crops: Combining Bioinformatics Educational Tools and Artificial Intelligence Applications
Authors: Zhang Xin , Ibrahim Zakir , Khaskheli Muhammad Bilawal , Raza Hamad , Zhou Fanrui , Shamsi Imran Haider
Published: September 2024

Abiotic stresses, including drought, salinity, extreme temperatures and nutrient deficiencies, pose significant challenges to crop production and global food security. To combat these challenges, the integration of bioinformatics educational tools and AI applications provide a synergistic approach to identify and analyze stress-responsive genes, regulatory networks and molecular markers associated with stress tolerance. Bioinformatics educational tools offer a robust framework for data collection, storage and initial analysis, while AI applications enhance pattern recognition, predictive modeling and real-time data processing capabilities. This review uniquely integrates bioinformatics educational tools and AI applications, highlighting their combined role in managing abiotic stress in plants and crops. The novelty is demonstrated by the integration of multiomics data with AI algorithms, providing deeper insights into stress response pathways, biomarker discovery and pattern recognition. Key AI applications include predictive modeling of stress resistance genes, gene regulatory network inference, omics data integration and real-time plant monitoring through the fusion of remote sensing and AI-assisted phenomics. Challenges such as handling big omics data, model interpretability, overfitting and experimental validation remain there, but future prospects involve developing user-friendly bioinformatics educational platforms, establishing common data standards, interdisciplinary collaboration and harnessing AI for real-time stress mitigation strategies in plants and crops. Educational initiatives, interdisciplinary collaborations and trainings are essential to equip the next generation of researchers with the required skills to utilize these advanced tools effectively. The convergence of bioinformatics and AI holds vast prospects for accelerating the development of stress-resilient plants and crops, optimizing agricultural practices and ensuring global food security under increasing environmental pressures. Moreover, this integrated approach is crucial for advancing sustainable agriculture and ensuring global food security amidst growing environmental challenges.
Impact of Digital Transformation on Green Innovation in Manufacturing under Dual Carbon Targets
Authors: Yang Jianliang , Shan Hongbo , Xian Penglong , Xu Xiaomeng , Li Na
Published: September 2024

The development of green innovation in the manufacturing industry is crucial for sustainability, as it can lead to significant environmental and economic benefits. Meanwhile, the impact of digital transformation on green innovation in the manufacturing industry has been proven to be significant in a previous study. To further explore the impact of digital transformation on the development of green innovation in the manufacturing industry under the dual carbon goal, this article selects data from Chinese A-share manufacturing listed companies from 2013 to 2022 as the observation sample, proposes research hypotheses based on stakeholder theory, and conducts empirical analysis. The results indicate that digital transformation can significantly promote the development of green innovation in the manufacturing industry, which is transmitted through corporate environmental responsibility. Corporate environmental responsibility plays a partial mediating role in the impact of digital transformation on the development of green innovation. Meanwhile, media attention can strengthen the positive impact of digital transformation on green innovation. In heterogeneity analysis, it was found that the higher the institutional shareholding and analyst attention, the more likely a company’s digital transformation can promote green innovation. In addition, by comparing and analyzing the data of the two years before and after the proposal of the dual carbon target, it was found that the incentive effect of the dual carbon target did not achieve the expected effect in this article, which may be related to the short time of the proposal of the dual carbon target and the impact of the epidemic.
Comparison of Anaerobic Co-Digestion of Food Waste and Livestock Manure at Various Mixing Ratios under Mesophilic and Thermophilic Temperatures
Authors: Lee Wonbae , Kim Youngo , Kim Ho , Kim Moonil
Published: September 2024

In this study, the optimum mixing ratio of food waste (FW) and livestock manure (LM) was investigated to improve the methane yield efficiency and prohibit the inhibition factors (organic loading rate and NH4+) from inhibiting the anaerobic co-digestion of FW and LM under mesophilic and thermophilic conditions. The research involved the following: (I) the analysis of the characteristics of FW and LM, (II) the evaluation of the potential and toxicity of the anaerobic digestion of I have confirmed that there is no problem. FW and LM using the biochemical methane potential (BMP) and anaerobic toxicity assay (ATA) tests, (III) the evaluation of the anaerobic co-digestion of FW and LM using the BMP test, and (IV) the evaluation of the optimum mixing ratio using mathematical modeling. The characteristics of FW and LM were analyzed to evaluate the theoretical methane potential and inhibition factor. The BMP test was carried out to evaluate the concentration of the biodegradable organic matter, biogas production rate, and methane yield. The ATA test was carried out to evaluate the impact of the inhibition concentration. Ultimately, mathematical models, such as a first-order reaction and a modified Gompertz model, were implemented to evaluate the optimum mixing ratio for the anaerobic co-digestion of FW and LM. FW had a higher concentration of degradable organic matter than LM. The initial operational parameters of the anaerobic digestion were determined to be appropriate at an organic matter concentration of less than 2.5 g/L and a TN concentration of 2,000 mg/L. In conclusion, as a result of evaluation through mathematical models, it was determined that anaerobic microorganisms were more sensitive to inhibitory factors under the thermophilic condition than under the mesophilic condition, and the optimum mixing ratio of FW to LM was 5:1 (vol:vol) based on kinetic results (k: 0.080; Bu: 0.23 L CH4/g VSadded; P: 100.84 mL; Rm: 10.23 mL/day; λ: 1.44 days).
Leveraging BIM for Sustainable Construction: Benefits, Barriers, and Best Practices
Authors: Cheng Qiuli , Tayeh Bassam A. , Abu Aisheh Yazan I. , Alaloul Wesam Salah , Aldahdooh Ziad A.
Published: September 2024

The building sector is still criticized for its excessive energy use and negative environmental effects, even with significant improvements in recent years. It makes a major contribution to the world’s energy, waste, and water use. This study investigates the possible benefits of using Building Information Modeling (BIM) technology in environmentally friendly building methods. It also seeks to identify and rank the major obstacles to the industry’s integration of sustainability and BIM. The study aims to accomplish its research objectives by means of a questionnaire survey approach. The three primary categories of the possible benefits associated with BIM are social, economic, and environmental, which correspond to the generally acknowledged elements of sustainable development. The provision of a centralized database that facilitates the administration of the full building lifetime, less material waste, and increased design efficiency have all been noted as key benefits. In the building industry, BIM approaches have shown to be quite successful in improving sustainable practices. The study does, however, point out a few difficulties. The number of people with a BIM degree has increased significantly, but there are still not enough qualified professionals with the necessary knowledge and experience. Project managers with the necessary skills are needed to oversee BIM deployment successfully. They should be able to advice and counsel clients and other stakeholders on the benefits of BIM. Building professionals may maximize the environmental performance of structures across their lifetimes and make well-informed decisions by integrating sustainability concepts into the BIM process.
A Risk Management Strategy under Transfer Pricing for Multi-National Supply Chain along the Belt and Road Initiative
Authors: Li Ying , Cheng Ying
Published: September 2024

The “Belt and Road Initiative” (BRI) drives international trade more and more frequently, making exchange rates and taxes unavoidable issues for multi-national companies. Thus, exchange risk uncertainty and tax saving planning should be considered in the operational decisions of a multi-national supply chain. This paper constructs a Stackelberg game model with four composite modes to explore the risk-taking and hedging strategy of retailers with reference-dependent psychology. The results show that: (1) exchange rate risk is transmitted through all subjects under the cost-plus transfer pricing strategy, while it is transmitted only between headquarters and retailers under the resale-price transfer pricing strategy. (2) No matter which subject bears the exchange rate risk, the motivation is stronger under the resale-price transfer pricing strategy. (3) The effect of futures hedging exchange rate risk is influenced by retailer reference-dependent psychology. When the reference dependence coefficient is low, and the risk of positive exchange rate fluctuations is too high, the retailer chooses to hedge its exchange rate risk. At this time, the transfer pricing strategy should shift to cost-plus, and the exchange rate fluctuation range that each entity can afford is larger than before hedging.
Stability Analysis of Stable Circular Orbit in Multi-Static Black Hole Spacetime
Authors: Fan Zefang , Wang Yu , Wang Xianggao
Published: September 2024

We herein study the circular orbit stability of a static black hole system composed of multiple Reissner–Nordstrom (RN) black holes. By comparing the circular orbits of two static black holes, three static black holes (TBHs), four static black holes and five static black holes at different spacetime, we find that the continuity of their stable circular orbits changes, i.e., the peaks of the effective potentials are transformed from single-peaked to bi-peaked, and that the distance a between the black holes is the main reason for this change. This characteristic is completely different from the continuity of the stable circular orbit interval of any kind of single black hole in the past. After calculation, we obtain several critical values that lead to the change in circular orbit stability. The three fundamental frequencies (orbital frequency, radial local frequency, and vertical local frequency) are derived and compared for two different spacetimes of double and three black holes. We also analyse the effect of the black hole distance a on the three fundamental frequencies of circular orbits.
Analysis of a Bifurcation and Stability of Equilibrium Points for Jeffrey Fluid Flow through a Non-Uniform Channel
Authors: Thoubaan Mary G. , Al-Khafajy Dheia G. Salih , Wanas Abbas Kareem , Breaz Daniel , Cotîrlă Luminiţa-Ioana
Published: September 2024

This study aims to analyze how the parameter flow rate and amplitude of walling waves affect the peristaltic flow of Jeffrey’s fluid through an irregular channel. The movement of the fluid is described by a set of non-linear partial differential equations that consider the influential parameters. These equations are transformed into non-dimensional forms with appropriate boundary conditions. The study also utilizes dynamic systems theory to analyze the effects of the parameters on the streamline and to investigate the position of critical points and their local and global bifurcation of flow. The research presents numerical and analytical methods to illustrate the impact of flow rate and amplitude changes on fluid transport. It identifies three types of streamline patterns that occur: backwards, trapping, and augmented flow resulting from changes in the value of flow rate parameters.
Long-Term Management of Post-Stroke Spasticity with Botulinum Toxin: A Retrospective Study
Authors: Falcone Nicoletta , Leo Fabrizio , Chisari Carmelo , Dalise Stefania
Published: September 2024

Stroke-induced spasticity is a prevalent condition affecting stroke survivors, significantly impacting their quality of life. Botulinum Toxin A injections are widely used for its management, yet the long-term effects and optimal management strategies remain uncertain. This retrospective study analyzed medical records of 95 chronic stroke patients undergoing long-term BoNT-A treatment for spasticity. Demographic data, treatment duration, dosage variability, and dropout rates were assessed over a period ranging from 2 to 14 years. The study revealed a notable extension of the interval between BoNT-A injections throughout the treatment duration. Dropout rates peaked during the initial 5 years of treatment, perhaps due to perceived treatment ineffectiveness. Additionally, a trend of escalating dosage was observed across all groups, indicating a potential rise in the severity of spasticity or changes in treatment response over time. BoNT-A injections emerged as the predominant treatment choice for managing post-stroke spasticity. The delayed initiation of BoNT-A treatment underscores the need for heightened awareness among healthcare providers to recognize and manage spasticity promptly post-stroke. Patients’ expectations and treatment goals should be clearly defined to optimize treatment adherence, while the observed escalation in dosage and treatment intervals emphasizes the dynamic nature of spasticity and underscores the importance of monitoring long-term treatment outcomes.
Unveiling the Connection: Viral Infections and Genes in dNTP Metabolism
Authors: Lo Shih-Yen , Lai Meng-Jiun , Yang Chee-Hing , Li Hui-Chun
Published: September 2024

Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of genomic information within cells. The balance of the dNTP pool involves several cellular enzymes, including dihydrofolate reductase (DHFR), ribonucleotide reductase (RNR), and SAM and HD domain-containing protein 1 (SAMHD1), among others. DHFR is vital for the de novo synthesis of purines and deoxythymidine monophosphate, which are necessary for DNA synthesis. SAMHD1, a ubiquitously expressed deoxynucleotide triphosphohydrolase, converts dNTPs into deoxynucleosides and inorganic triphosphates. This process counteracts the de novo dNTP synthesis primarily carried out by RNR and cellular deoxynucleoside kinases, which are most active during the S phase of the cell cycle. The intracellular levels of dNTPs can influence various viral infections. This review provides a concise summary of the interactions between different viruses and the genes involved in dNTP metabolism.
Carvacrol and Thymol Enhance the Quality of Beni Arouss Buck Semen Stored at 4 °C Thanks to Their Antimicrobial Properties
Authors: Kchikich Amr , Kirschvink Nathalie , Raes Marianne , El Otmani Samira , Chebli Youssef , Bister Jean-Loup , El Amiri Bouchra , Barrijal Said , Chentouf Mouad
Published: September 2024

This study aims to investigate the impact of carvacrol and thymol on the quality of Beni Arouss buck semen stored in skim milk at 4 °C. Ejaculates were collected from eight Beni Arouss bucks weekly for 11 weeks, pooled, and then divided into three equal parts. Samples were diluted to 400 × 106 sperm/mL in skim milk (control) and skim milk supplemented with a single dose of 200 µM carvacrol and thymol each. Evaluations of sperm motility, viability, abnormalities, membrane integrity, lipid peroxidation, and bacterial growth were conducted at 0, 6, 24, and 48 h of liquid storage at 4 °C. After 48 h of storage, the results indicate that the addition of carvacrol positively influences total and progressive motility and viability. However, it also leads to a decrease in lipid peroxidation and bacterial growth compared to the control group (p < 0.05). Thymol showed similar results to carvacrol, except for progressive motility (p > 0.05). Bacterial growth was negatively correlated with total and progressive motility and viability (p < 0.05), while no correlation between lipid peroxidation and these parameters was observed (p > 0.05). In conclusion, the addition of carvacrol and thymol to skim milk extender moderately improves the quality of Beni Arouss buck semen after 48 h storage at 4 °C due to its antimicrobial activity.
A Harmony-Based Approach for the Evaluation and Regulation of Water Security in the Yellow River Water-Receiving Area of Henan Province
Authors: Zhang Zhiqiang , Wang Weiwei , Zhang Xiuyu , Zhang Hui , Yang Li , Lv Xizhi , Xi Xu
Published: September 2024

Water security, as a crucial component of national security, plays a significant role in maintaining regional stability and ensuring the healthy and rapid development of the economy and society. The Yellow River water-receiving area of Henan Province (YRWAR-HN) is selected as the research area in this study. Firstly, a comprehensive evaluation index system is constructed based on the actual water security problems of the research area, and the single index quantification–multiple indices syntheses–poly-criteria integration method (SMI-P) is introduced to quantify the water security degree of 14 cities in the YRWAR-HN from 2010 to 2021. Then, the obstacle degree model is used to identify the key obstacle indexes that restrict the improvement of water security. Finally, the harmonious behavior set optimization method is adopted to carry out the regulation of water security, and the improvement path of water security in the YRWAR-HN is formulated. The results indicate the following: (1) the water security degree of the YRWAR-HN shows a fluctuating upward trend, increasing from 0.4348 (2010) to 0.6766 (2021), a significant rise of 55.61%. The water security level improves from the relatively unsafe level to the relatively safe level. Hebi City exhibits the fastest rate of water security improvement, while Xinxiang City shows the slowest rate. (2) The density of the river network (X1) and the proportion of investment in water conservancy and environmental protection in the total investment (X15) are the two indexes with the highest obstacle degree, with the average obstacle degrees being 15.09% and 10.79%, respectively. (3) The combination of the composite regulation scenario and improvement Path 2 is the optimal regulation strategy for water security in the YRWAR-HN. From the implementation process, Luoyang, Sanmenxia, Jiyuan, Xuchang, and Shangqiu may prioritize improving their flood and drought disaster defense capabilities and emergency response capabilities, continuously enhancing the flood prevention and disaster reduction system. Zhengzhou, Kaifeng, Xinxiang, Jiaozuo, Anyang, Hebi, Pingdingshan, and Zhoukou may prioritize resolving the regional water supply and demand conflicts, balancing development and conservation, actively seeking transboundary and external water transfers, and strengthening the capacity for water conservation and intensive utilization. Puyang City may prioritize enhancing its comprehensive water environment management capabilities, increasing investment in water conservancy and the environment, improving production processes, reducing pollutant emissions, and mitigating agricultural non-point source pollution.
Comprehending Spatial Distribution and Controlling Mechanisms of Groundwater in Topical Coastal Aquifers of Southern China Based on Hydrochemical Evaluations
Authors: He Jun , Wu Pan , Li Yiyong , Zeng Min , Chen Chen , Jakada Hamza , Zhao Xinwen
Published: September 2024

Groundwater quality and availability in coastal aquifers have become a serious concern in recent times due to increased abstraction for domestic, agricultural and industrial purposes. (1) Background: Zhuhai city is selected as a representative coastal aquifer in Southern China to comprehensively evaluate the hydrochemical characteristics, spatial distribution and controlling mechanisms of groundwater. (2) Methods: A detailed study utilizing statistical analyses, a Piper diagram, Gibbs plots, and ion ratios was conducted on 114 surface water samples and 211 groundwater samples. (3) Results: The findings indicate that the pH of most groundwater is from 6.06 to 6.52, indicating a weakly acidic environment. The pH of surface water ranges from 5.35 to 9.86, with most values being weakly alkaline. The acidity in the groundwater may be related to the acidic atmospheric precipitation, an acidic unsaturated zone, oxidation of sulphide minerals and tidal action. The groundwater chemical types are predominantly mixed, followed by Ca-Mg-HCO3 type. Surface water samples are predominantly Na-Cl-SO4 type. The NO3− concentration in groundwater is relatively high, with a mean value of 17.46 mg/L. The NO2− and NH4+ concentrations in groundwater are relatively low, with mean values of 0.46 mg/L and 7.58 mg/L. (4) Conclusions: The spatial distribution of the principal chemical constituents in the groundwater is related to the landform. The chemical characteristics of groundwater in the study area are mainly controlled by the weathering and dissolution of silicate and sulfate minerals, evaporation, seawater mixing and cation exchange. Nitrate in clastic fissure groundwater, granite fissure groundwater and unconfined pore groundwater primarily originates from atmospheric precipitation, agricultural activities of slope farmland and forest land. Nitrate in confined pore groundwater and karst groundwater primarily originates from domestic sewage and mariculture wastewater. Our findings elucidate the processes characterizing the hydrogeology and surface water interactions in Zhuhai City’s coastal system, which are relevant to other catchments with similar geological characteristics.
Making Home Here: Young Refugee-Migrant Women and the Work of Emplacement in a Rural Appalachian Town
Authors:   , Muraleedharan Valentina
Published: September 2024

This dissertation centres young refugee-migrant women’s voices, perspectives, concerns, and actions living in a small, rural Appalachian town called Easton, exploring their social, cultural, and economic experiences. It infers that through their critical participation in family life and labour in making a home in a new place, young refugee-migrant women’s relations to family and place impact how they negotiate their aspirations and future im/mobilities to create pathways to emplacement. Emplacement is an ongoing process that hinges on the efforts of individuals, families, and communities to find a way in a new place by giving meaning to their surroundings. This research has also sought to advance the theory of emplacement through the displaced experiences of young refugee-migrant women. It draws from over 30 in-depth interviews with young refugee-migrant women, their families, and other key collaborators, as well as participant observation, field notes, and time spent in place over the course of 3 years.
Digital transformation as a factor in reducing labor shortages in Russian agriculture
Authors:   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — Moscow Timiryazev Agricultural Academy», Moscow, Russia, Beketova O. N. , Demichev V. V. ,   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — Moscow Timiryazev Agricultural Academy», Moscow, Russia, Ivanov A. M. ,   Federal State Budgetary Educational Institution of Higher Education «Russian State University for Humanities», Moscow, Russia
Published: September 2024

This article examines the dynamics of the number of employees of agricultural organizations, the dynamics of energy availability, electrical equipment, the level of mechanization and technical equipment as key conditions for the introduction of digital solutions and the reduction of labor shortages in the industry. In addition, an analysis of the dynamics of labor costs in the sectoral and product context was carried out, which allows us to identify the most labor-intensive and requiring the introduction of digital solutions in the agricultural sub-sector. The key digital technologies that contribute to reducing the shortage of labor resources have been studied. A factorial regression model is proposed that allows us to study the impact of digital transformation on reducing the labor costs of producing a unit of production. The results of the study allowed us to propose an approach to assessing the impact of the digital transformation of agriculture on labor costs and reducing the shortage of labor resources of an industry or an individual enterprise (group of enterprises), consisting in analyzing the dynamics of the need for workers, the conditions of technical equipment of production, labor costs and approximation based on a regression model of the impact of digital transformation technologies on labor cost reduction.
Correlation and regression analysis of the influence of economic factors on wheat yield
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russia, Khoruzhiy V. I. , Bykov D. V. ,   Russian State Agrarian University — Moscow Timiryazev Agricultural Academy, Moscow, Russia, Ukolova A. V. ,   Russian State Agrarian University — Moscow Timiryazev Agricultural Academy, Moscow, Russia, Ibragimov A. G. ,   Russian State Agrarian University — Moscow Timiryazev Agricultural Academy, Moscow, Russia
Published: September 2024

The article presents the results of econometric modeling of wheat yield based on microdata from reports on the financial and economic status of agricultural producers. The relationship between wheat yield and economic factors is studied: indicators of the level of intensity (costs of mineral fertilizers, cost of fixed assets, direct labor costs for grain production, number of workers employed in agriculture per unit area) and specialization of agricultural production (proportion of revenue from sales of crop products in revenue from sales of agricultural products). Using the stepwise variable selection approach, statistically significant linear regression models were constructed that can be used for analysis and forecasting. The paired model included the cost of mineral fertilizers per 1 ha of sown area as a factor in wheat yield (coefficient of determination R2 = 0.503), and multiple regression was obtained by adding a second factor — the cost of fixed assets per 100 ha of agricultural land (multiple coefficient of determination R2 = 0.562). Decomposition of the multiple coefficient of determination into separate coefficients of determination allowed us to estimate the impact of each factor included in the model on yield: thus, the impact of mineral fertilizer costs was 42 %, and the impact of fixed assets was 15 %. According to the approach to decomposition of R2 based on β-coefficients, the net impact of mineral fertilizer costs on wheat yield was 35 %, the net impact of fixed assets was 5 %, while the impact of the systemic effect from the interaction of the two factors, which reflects the level of production intensification, was 17 %. Based on a multiple regression model, forecast values were constructed and estimated, and reserves for yield growth were determined.
Statistical analysis of the transformation of agricultural production in various categoriesof farms and forms of management
Authors:   Kaluga branch of the Russian State Agrarian University — Moscow Timiryazev Agricultural Academy, Kaluga, Russia, Goreeva N. M. , Demidovа L. N. ,   FSBEI of Higher Education «MIREA — Russian University of Technology», Moscow, Russia, Kokorev N. A. ,   Kaluga branch of the Russian State Agrarian University — Moscow Timiryazev Agricultural Academy, Kaluga, Russia, Chernova Y. V. ,   Kaluga Branch Financial University under the Government of the Russian Federation, Kaluga, Russia
Published: September 2024

Agriculture is a complex material process, where the starting point is the presence of certain factors of production, productive forces and a special factor — land resources. The functioning and development of agriculture are associated with numerous threats and risks that require their assessment, monitoring, identification, taking into account the size of the industry, which is important from the point of view of forming directions for further promising development, obtaining maximum profit at the lowest cost. The institutional component also remains extremely important: the optimal form of organization of agricultural production, in which the available resources can be used in the best way. For the most complete and comprehensively in-depth assessment of the quantitative and qualitative transformation of the agricultural sector, the methodology of statistics has been applied. Based on the use of Salai and integral Ryabtsev indicators, the article characterizes the structural differences in agricultural production in the context of business categories and organizational and legal forms over 30 years; substantiates approaches to the optimal selection and use of analytical tools to assess the size of production in order to identify the most effective. Based on the estimated data, the main trends in the development of the industry have been identified, the results of the functioning of the activities of a set of organizations by categories of farms and organizational and legal forms have been summarized. The provisions of the article can be used to model threats, risks and predict the further vector of agricultural development in the formation of directions of state support, adjustment of fiscal policy for different categories of farms.
Inovação pedagógica e aprendizagem na infância: o caso de uma Organização Não Governamental no interior da Bahia
Authors: Silva Maria Djani Alves , Pereira Maria Gorete Gonçalves Rocha , Santos Paulo César Marques de Andrade
Published: September 2024

O desenvolvimento cognitivo, psicológico, físico e intelectual na infância, de maneira integral, é o maior desafio para os profissionais que atuam na Educação Infantil. Objetiva-se verificar se no contexto do Projeto Ágape, existem práticas pedagógicas que promovam a aprendizagem de forma inovadora. O percurso de investigação, desenvolveu-se com a imersão no ambiente natural dos sujeitos pesquisados, através da abordagem etnográfica; fazendo uso de técnicas e instrumentos como: observação participante, entrevista não estruturada, diário de campo, coleta de documentos, entre outros. O estudo foi realizado em uma ONG – Organização não Governamental, ou seja, uma instituição sem fins lucrativos e atende crianças de 1 a 7 anos de idade, na modalidade semi-internato e internato. Os resultados do estudo revelam a prática pedagógica emergente, e a busca incessante pela aprendizagem, na qual o professor atua como mediador e não como principal detentor do saber. O que permite concluir que as ações desenvolvidas dentro da instituição pesquisada, caracterizam uma prática pedagógica inovadora, em que o papel das ações desenvolvidas dentro da instituição foi de criar um ambiente propício a aprendizagem, no qual as professoras atuam ao mesmo tempo como facilitadoras e mediadores das habilidades apresentadas pelas crianças, diferenciando do paradigma fabril, em que persiste os modelos tradicionais de muitas instituições.
Exploring the therapeutic effects of Moringa Oleifera on inflammation and chronic diseases
Authors: Oliveira Junior Paulo Cezar de , Moraez Daniel Forjaz de , Oliveira Carlos Rocha
Published: September 2024

Background: The inflammatory process is an immune system response to injuries, infections, or harmful stimuli. Chronic Diseases are diseases that are mostly immune-mediated by inflammatory mediators, and according to the World Health Organization, these diseases represent 74% of the causes of death in the world. Moringa oleifera (M. oleifera), is a versatile plant rich in bioactive compounds, has garnered attention for its potential therapeutic properties. Objective:  this study aims to investigate the anti-inflammatory properties of M. oleifera and its potential influence on chronic diseases as well. Methods: This review was performed based systematic analysis of literature. Results: Anti-inflammatory activity was observed through the reduction in levels of IL-1, IL-6, IL-10, TNF-alpha, prostaglandin E2, and COX-2. Additionally, anti-hyperglycemic effects, normalization of lipid profiles, regeneration of hepatocytes and pancreatic beta cells, and a reduction in the concentration of reactive oxygen species were also described. Conclusion: These findings support the use of the M. oleifera plant as an effective treatment for diseases/disorders associated with inflammation.
Investigation Of Wastewater Treatment Plant Sustainability Potential In Terms Of Resource Recovery Essentials
Authors:   ,   Institute of Technology Tralee, Moloney Aoife
Published: September 2024

"This thesis aims to explore the sustainability potential which exists in Wastewater Treatment Plants (WWTP's); particularly focusing on nutrient, energy, and water recovery and reuse. The core of the research will focus on the establishment of a sustainable Resource Recovery Treatment Plant (RRTP) plan for Limerick Main Drainage (LMD) WWTP, and potentially utilising this as a case study plant which could act as a foundation example within the sector. There is a genuine need to investigate more sustainable options in wastewater treatment (WWT); increasing energy and sludge management costs are a real issue for non-sustainable WWTP's given that thousands of euro's are spent per annum on these expenditures. Other drivers exist such as increasing global population, increased urbanisation, climate change, requirements to reduce greenhouse gas emissions (GHG), energy scarcity and security of supply issues, depletion of finite resources such as Phosphorus and water shortage issues. These difficulties are fast becoming increasingly important to deal with now before the damaging effects of climate change becomes irreversible, or before we face stark scarcity of fuel supply issues, or before we deplete our finite resources completely. Alternative solutions and a more sustainable approach are required on a global scale."
Synthesis and study of the properties of nanocomposite polyurethane-polyisocyanurate foams obtained with the usage of Cloisite 30B nanoclay small additives
Authors: Vlasov R. R. , Ryabova D. I. , Ryabov S. A. , Zaycev S. D.
Published: September 2024

A series of nanocomposite polyurethane-polyisocyanurate foams were obtained using chemically modified Cloisite 30B nanoclays. The influence of small additives of Cloisite 30B nanoclay on the morphology of the cellular structure and changes in the physical, mechanical and thermal characteristics of the synthesized materials was analyzed. It has been proven that the introduction of this filler into the composition in small quantities contributes to the ordering of the cellular structure and the improvement of the basic functional foams’ properties.
ESPAÇO MARÍTIMO BRASILEIRO E SEGURANÇA NO TRÁFEGO AQUAVIÁRIO
Authors: Geara Guedes de Oliveira Juliana
Published: September 2024

Maritime Traffic in Brazilian Jurisdictional Waters (BJW) is essential for trade, research, and recreational activities. However, it requires strict compliance with national and international regulations to ensure navigational safety, protect human life at sea, and preserve the marine environment. This abstract addresses the challenges and procedures related to the enforcement and application of these regulations. The objective of this work is to highlight the importance of maritime surveillance in BJW and how it contributes to maintaining a safe waterway environment. To achieve this goal, we examined legislation, the roles of maritime authorities, and inspection procedures, emphasizing the roles of naval inspectors at diferente levels. The methodology involved the analysis of regulations, laws, and documents related to waterway traffic safety, as well as the description of activities performed by naval inspectors at different levels of operation. We also highlighted the administrative measures and penalties that can be imposed in case of violations. To summarize, maritime surveillance plays a fundamental role in maintaining navigational safety, preventing environmental pollution, and protecting human life at sea in Brazilian Jurisdictional Waters. Through this constant surveillance, waterway traffic in BJW can be conducted efficiently and safely.
Practical aspects of pain relief in palliative medicine
Authors: Nesterenko V.G. , Mykhnevych K.G.
Published: September 2024

Background. Treatment of chronic pain in adults and children is regulated by the national standard of Ukraine, which recommends adherence to the choice of painkillers in accordance with the WHO three-step protocol. But the treatment standard does not detail the use of painkillers according to nosological units.

The aim of the work was to determine the need for different types of analgesia in palliative patients depending on the main palliative diagnosis.

Materials and Methods. System analysis, aggregation and bibliosemantic methods were used. The list of palliative diagnoses was determined when studying the need and forecasting the need for palliative and hospice care according to the methodology of the Ukrainian Center for Social Data (2019), improved by us in 2021–2024.

Results and Conclusions. The conducted research made it possible to determine the predominant types of pain, their possible intensity and corresponding groups of pharmaceutical drugs with an analgesic effect in the units from the list of palliative diseases proposed by us. Neuropathic pain is mainly present in diabetes (diabetic polyneuropathy) and phenylketonuria. Predominantly nociceptive pain is present in cardiovascular diseases of palliative stages, tuberculosis, rheumatoid arthritis, cystic fibrosis and chronic hepatitis in children. Predominantly mixed (nociceptive and neuropathic types of pain at the same time) characteristic of HIV/AIDS, epilepsy, dementia, multiple sclerosis, fibrosis and cirrhosis of the liver, chronic obstructive pulmonary disease, palliative stage kidney disease in adults, cerebral palsy, inflammatory diseases of the central nervous system and mucopolysaccharidoses in children. We proposed to clarify the national standard for treatment of chronic pain in adults and children, and to define the necessary non-steroidal anti-inflammatory drugs, non-narcotic analgesics, weak and strong opioids, anticonvulsants, antidepressants, and other adjuvants with an analgesic effect. The perspective of further studies is to detail the dosage of drugs with an analgesic effect and to calculate the need at the national level for reimbursement under the "Affordable Medicines" program.

Keywords: neuropathic pain, nociceptive pain, analgesics, opioids, reimbursement.
Pistes didactiques pour un dispositif de télécollaboration interculturelle en ligne entre apprenants du français langue étrangère
Authors: Mehyaoui Adila
Published: September 2024

À l’heure de toutes les mutations que connaît le monde contemporain, y compris dans le domaine de l’éducation et de l’enseignement supérieur, il n’est plus à démontrer que nous sommes témoins d’une (r)évolution incontestable des « usages et pratiques pédagogiques » au vu des différentes transformations didactiques qui marquent cette époque, a fortiori, avec l’évolution effrénée des technologies nouvelles et le développement de la convergence numérique. Dans la sphère de l’utilisation de ce qui est appelé technologies de l’information et de la communication pour l’enseignement , plus connues sous l’acronyme TICE, il est nécessaire de leur reconnaître un impact non négligeable sur l’ensemble de la société de l’information et de la connaissance. Pour ne focaliser que sur le cadre didactique et de ce que les TICE pourraient apporter comme plus-value, il devient incontournable de renouveler la modernisation des moyens utilisés dans l’enseignement imposant une interaction entre les différents acteurs impliqués dans la croisée d’une coopération interdisciplinaire. Pour mieux expliquer notre propos, nous nous verrons passer en revue, dans un premier temps, certaines définitions qui se révèlent nécessaires pour appréhender la notion de société de l’information et de la connaissance. Ensuite, nous nous arrêterons sur le rôle qu’endossent les nouvelles technologies pour la transmission de l’information et la diffusion du savoir en milieu académique, en émettant un regard historique sur l’utilisation de ces outils, leur développement et leur intégration dans les pratiques pédagogiques, y compris celles qui sont relatives à la didactique des langues. Enfin, nous porterons une réflexion spécifique au contexte francophone, suite à une expérience inédite relative à un public d’apprenants universitaires roumains avides de l’apprentissage de la langue française, celle-ci représentant pour eux un gage d’une véritable émancipation culturelle mais aussi académique et scientifique et ce à travers la proposition d’un dispositif de télécollaboration interculturelle.
REGULATION OF RETINOGENESIS IN PRENATAL ONTOGENESIS AND ITS DISRUPTION IN AGE-RELATED MACULAR DEGENERATION
Authors: Reva Ivan , Shaharyar Islam , Kalashnik Anna , Mozhilevskaya Ekaterina , Soroka Anatoly , Zolotov Alexander , Lukyanchuk Egor , Bondar Evgeni , Gaynullina Yulia , Reva Galina
Published: September 2024

One of the main causes of blindness in the elderly in developed countries is age-related macular degeneration (AMD) [1, 2, 3]. Active research is being conducted to identify putative molecular targets for the development of an effective strategy for conservative treatment of both atrophic and neovascular forms of this disease [4, 5, 6], but at the present stage, pharmacotherapy is effective only for some patients, and is insufficient to stop the progression of the disease or eliminate the damage that has already occurred. The most promising and promising potential treatment options are considered to be the introduction of cellular technologies with retinal cell replacement and targeted pharmacotherapy. The aim of this study was to investigate the role of the retinal development inducer, SIRT1 [7, 8, 9], in retinogenesis to justify pharmacological inhibition of this protein as a possible treatment option for neovascular AMD. Using immunohistochemistry and immunocytochemistry, we assessed the expression and subcellular localization of SIRT1 and its innate inhibitor DBC1 in the retina of fetuses, adults, and mice. We also studied SIRT1 in retinal progenitor cells derived from mice and humans, the former having been used in small interfering RNA studies. SIRT1 is widely expressed in the developing and adult retina and is a regulator of key genes in retinal development, namely PAX6, Nestin, and CRX [10, 11, 12]. Moreover, we found that photoreceptor progenitor cells were among the smallest cells in a heterogeneous mouse retinal progenitor cell population [13, 14, 15]. Collectively, these results provide a basis for manipulating SIRT1 expression in small retinal progenitors as a means to increase the yield of photoreceptors for transplantation in retinal degeneration models [16, 17]. Furthermore, SIRT1 was found to be highly expressed in human-derived choroidal neovascular membranes, allowing its activity to be pharmacologically inhibited by the drug nicotinamide as a potent regulator of angiogenic and hypoxic signaling in a human retinal pigment epithelial cell line at both the protein level using angiogenesis arrays and at the RNA level using whole genome microarrays [18, 19]. These results point to the SIRT1 inhibitor, Nicotinamide, as a possible agent for treatment of neovascular AMD. Further studies of Nicotinamide are warranted in animal models of AMD. To the best of our knowledge, this is the first time that a detailed analysis of SIRT1 as a regulator of both retinal development and choroidal neovascularization has been reported.
PECULIARITIES OF ORAL CANCERS IN POLAND - A REVIEW OF THE LITERATURE
Authors: Górka Tymoteusz , Sobik Karolina , Zatyka Piotr , Slomczynski Adam , Rabenda Michal , Pawłowska Agata , Janik Piotr
Published: September 2024

Oral cancers are seen frequently. By 2040, according to the Global Cancer Observatory (GCO), their number will increase by around 40%. Exposure to alcohol, tobacco smoke, human papillomavirus (HPV) or a diet low in fibre is often part of everyday life, which is a risk factor for developing oral cancer. The most common of these is oral squamous cell carcinoma. The most common treatment is primary surgical resection with or without postoperative adjuvant therapy. In addition, various combination therapies including chemotherapy with radiotherapy or immunotherapy are used. Oral cancers are usually detected early but delayed treatment can lead to a bad prognosis and require facial reconstructive surgery. Aim: The aim of the publication was to bring together the latest information on oral cancer in Poland. We wanted to present the division, the most commonly observed symptoms and the proposed treatment. Methods: Analysis of information on oral cancer using PubMed sources, including classification of cancer types, symptoms and possible treatments. Conclusions: Oral cancers are a common problem for the population of Poland. Their incidence is likely to increase over the next decade. The environment, lifestyle and diet have a key influence on their formation. The most common treatment is their resection combined with radiation therapy, chemotherapy or immunotherapy.