bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurotoxicity of Pesticides: The Roadmap for the Cubic Mode of Action
Authors: Bumbăcilă Bogdan , Putz Mihai V.
Published: July 2019

Pesticides are used today on a planetary-wide scale. The rising need for substances with this
biological activity due to an increasing consumption of agricultural and animal products and to the
development of urban areas makes the chemical industry to constantly investigate new molecules or to
improve the physicochemical characteristics, increase the biological activities and improve the toxicity
profiles of the already known ones. Molecular databases are increasingly accessible for in vitro and in
vivo bioavailability studies. In this context, structure-activity studies, by their in silico - in cerebro
methods, are used to precede in vitro and in vivo studies in plants and experimental animals because
they can indicate trends by statistical methods or biological activity models expressed as mathematical
equations or graphical correlations, so a direction of study can be developed or another can be abandoned,
saving financial resources, time and laboratory animals. Following this line of research the present paper
reviews the Structure-Activity Relationship (SAR) studies and proposes a correlation between a topological
connectivity index and the biological activity or toxicity made as a result of a study performed on 11 molecules
of organophosphate compounds, randomly chosen, with a basic structure including a Phosphorus atom
double bounded to an Oxygen atom or to a Sulfur one and having three other simple covalent bonds with two
alkoxy (-methoxy or -ethoxy) groups and to another functional group different from the alkoxy groups. The
molecules were packed on a cubic structure consisting of three adjacent cubes, respecting a principle of topological
efficiency, that of occupying a minimal space in that cubic structure, a method that was called the Clef
Method. The central topological index selected for correlation was the Wiener index, since it was possible
this way to discuss different adjacencies between the nodes in the graphs corresponding to the organophosphate
compounds molecules packed on the cubic structure; accordingly, "three dimensional" variants of these
connectivity indices could be considered and further used for studying the qualitative-quantitative relationships
for the specific molecule-enzyme interaction complexes, including correlation between the Wiener
weights (nodal specific contributions to the total Wiener index of the molecular graph) and the biochemical
reactivity of some of the atoms. Finally, when passing from SAR to Q(uantitative)-SAR studies, especially by
the present advanced method of the cubic molecule (Clef Method) and its good assessment of the
(neuro)toxicity of the studied molecules and of their inhibitory effect on the target enzyme - acetylcholinesterase,
it can be seen that a predictability of the toxicity and activity of different analogue compounds can
be ensured, facilitating the in vivo experiments or improving the usage of pesticides.
Pharmacologic Agents for the Treatment of Vasodilatory Shock
Authors: Knotzer Hans , Poidinger Bernhard , Kleinsasser Axel
Published: July 2019

:

Vasodilatory shock is a life-threatening syndrome in critically ill patients and is characterized by severe
hypotension and resultant tissue hypoperfusion. This shock state requires the use of vasopressor agents to
restore adequate vascular tone.

:

Norepinephrine is still recommended as first-line vasopressor in the management of critically ill patients suffering
from severe vasodilation. In the recent time, catecholaminergic vasopressor drugs have been associated with
possible side effects at higher dosages. This so-called catecholamine toxicity has focused on alternative noncatecholaminergic
vasopressors or the use of moderate doses of multiple vasopressors with complementary
mechanisms of action. Besides vasopressin and terlipressin, angiotensin II may be a promising drug for the management
of vasodilatory shock. In addition, adjunctive drugs, such as hydrocortisone, methylene blue or ascorbic
acid can be added to conventional vasopressor therapy.

:

The objective of this review is to give an overview of the current available vasopressor agents used in vasodilatory
shock. A thorough search of PubMed was conducted in order to identify the majority of studies related to the
subject. Data on the outcome of several drugs and future perspective of possible management strategies for the
therapy of vasodilatory shock are discussed.
Biochemometrics and Required Tools in Botanical Natural Products Research: A Review
Authors: Wyss Kevin M. , Llivina Graham C. , Calderón Angela I.
Published: July 2019

This review serves to highlight the role of chemometrics and biochemometrics in recent
literature as well as including a perspective on the current state of the field, as well as the future needs and
possible directions. Specifically examining the analytical methods and statistical tools that are available to
chemists, current applications of QTOF-MS, Orbitrap-MS, LC with PDA/UV detectors, NMR, and IMS
coupled MS are detailed. Of specific interest, these techniques can be applied to botanical dietary
supplement quality, efficacy, and safety. Application in natural products drug discovery, industrial quality
control, experimental design, and more are also discussed.
Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development
Authors: Liu Song-Bai , Qiu Xiu-Qin , Guo Wei-Qiang , Li Jin-Li , Su Qian , Du Jia-Hui , Hu He-Juan , Wang Xiao-Xiao , Song Yao-Hua , Lou Xiao , Xu Xiang-Bin
Published: July 2019

Aim and Objective:

Flap endonuclease-1 (FEN1) plays a central role in DNA replication and
DNA damage repair process. In mammals, FEN1 functional sites variation is related to cancer and chronic
inflammation, and supports the role of FEN1 as a tumor suppressor. However, FEN1 is overexpressed in
multiple types of cancer cells and is associated with drug resistance, supporting its role as an oncogene.
Hence, it is vital to explore the multi-functions of FEN1 in normal cell metabolic process. This study was
undertaken to examine how the gene expression profile changes when FEN1 is downregulated in 293T
cells.

Materials and Methods:

Using the RNA sequencing and real-time PCR approaches, the transcript
expression profile of FEN1 knockdown HEK293T cells have been detected for the next step evaluation,
analyzation, and validation.

Results:

Our results confirmed that FEN1 is important for cell viability. We showed that when FEN1
downregulation led to the interruption of nucleic acids related metabolisms, cell cycle related metabolisms
are significantly interrupted. FEN1 may also participate in non-coding RNA processing, ribosome RNA
processing, transfer RNA processing, ribosome biogenesis, virus infection and cell morphogenesis.

Conclusion:

These findings provide insight into how FEN1 nuclease might regulate a wide variety of
biological processes, and laid the foundation for understanding the role of other RAD2 family nucleases in
cell growth and metabolism.
Classical Steroids in a New Fashion: Focus on Testosterone and Aldosterone
Authors: Jezova Daniela , Balagova Lucia , Chmelova Magdalena , Hlavacova Natasa
Published: July 2019

Several endocrine glands produce steroid hormones. Thanks to the work of chemists and
biochemists, the main synthetic as well as metabolic pathways of steroid hormones were included in the
textbooks more than 50 years ago and the classical endocrine gland functions were identified. Later on,
evidence of steroid hormone effects beyond the classical endocrine gland function has been accumulating.
Testosterone was shown to participate in the stress response and may influence coping with stressors.
We have shown a decrease in testosterone concentrations in saliva in children undergoing a school
exam compared to values on a non-exam school day. Testosterone has been associated with different
cognitive functions in both adults and children. Circulating testosterone has been linked to negative
symptoms of schizophrenia. Aldosterone is acting via mineralocorticoid receptors, which are thought to
be fully occupied by glucocorticoids in the brain. Until now, an action of aldosterone in the brain has
not been considered at all, because the enzyme 11-beta-hydroxysteroid dehydrogenase type 2, which
would enable aldosterone to bind to receptors is absent in most of the brain areas. We have brought
evidence that aldosterone can act in the brain and produce anxiogenic and depressogenic effects. To
facilitate the translation of animal findings into clinical research, we have developed methodology for
measurement of salivary aldosterone and obtained first data on a relationship between salivary aldosterone
and trait anxiety. We have shown that salivary aldosterone concentrations reflect treatment outcome
in patients with major depressive disorder.
ATP-Diphosphohydrolases in Parasites: Localization, Functions and Recent Developments in Drug Discovery
Authors: de Carvalho Lara Soares Aleixo , Junior Ismael José Alves , Junqueira Lauriene Ricardo , Silva Lívia Mara , Riani Lorena Rodrigues , de Faria Pinto Priscila , Da Silva Filho Ademar Alves
Published: July 2019

ATP-diphosphohydrolases (EC 3.6.1.5), also known as ATPDases, NTPases, NTPDases, EATPases or apyrases, are enzymes that hydrolyze a variety of nucleoside tri- and diphosphates to their respective nucleosides, being their activities dependent on the presence of divalent cations, such as calcium and magnesium. Recently, ATP-diphosphohydrolases were identified on the surface of several parasites, such as Trypanosoma sp, Leishmania sp and Schistosoma sp. In parasites, the activity of ATPdiphosphohydrolases has been associated with the purine recuperation and/or as a protective mechanism against the host organism under conditions that involve ATP or ADP, such as immune responses and platelet activation. These proteins have been suggested as possible targets for the development of new antiparasitic drugs. In this review, we will comprehensively address the main aspects of the location and function of ATP-diphosphohydrolase in parasites. Also, we performed a detailed research in scientific database of recent developments in new natural and synthetic inhibitors of the ATPdiphosphohydrolases in parasites.
Natural Compounds Targeting Cancer Stem Cells: A Promising Resource for Chemotherapy
Authors: Das Plabon K. , Zahan Tasnim , Abdur Rakib Md. , Khanam Jahan A. , Pillai Suja , Islam Farhadul
Published: July 2019

Background:

Cancer Stem Cells (CSCs) are the subpopulation of cancer cells which are directly involved in drug resistance, metastases to distant organ and cancer recurrence.

Methods:

A systematic literature search was conducted through various electronic databases including, Pubmed, Scopus, Google scholar using the keywords "cancer stem cells" and "natural compounds" in the present study. Articles published between 1999 and 2019 were reviewed. All the expositions concerning CSCs associated cancer pathogenesis and therapy resistance, as well as targeting these properties of CSCs by natural compounds were selected for the current study.

Results:

Natural compounds have always been thought as a rich source of biologically active principles, which target aberrantly activated signaling pathways and other modalities of CSCs, while tethering painful side effects commonly involved in the first-line and second-line chemo-radiotherapies. In this review, we have described the key signaling pathways activated in CSCs to maintain their survival and highlighted how natural compounds interrupt these signaling pathways to minimize therapy resistance, pathogenesis and cancer recurrence properties of CSCs, thereby providing useful strategies to treat cancer or aid in cancer therapy improvement. Like normal stem cells, CSCs rely on different signaling pathways and other properties for their maintenance. Therefore, the success of cancer treatment depends on the development of proper anti-neoplastic drugs capable of intercepting those signaling pathways as well as other properties of CSCs in order to eradicate this evasive subpopulation of cancer cells.

Conclusion:

Compounds of natural origin might act as an outstanding source to design novel therapies against cancer stem cells.
Cranberry: A Promising Natural Source of Potential Nutraceuticals with Anticancer Activity
Authors: Mantzorou Maria , Zarros Apostolos , Vasios Georgios , Theocharis Stamatios , Pavlidou Eleni , Giaginis Constantinos
Published: July 2019

Studies have shown that cranberry and its components may exert anticancer properties. The present study aims to critically summarise the existing experimental studies evaluating the potential effects of cranberry on cancer prevention and treatment. PubMed database was searched to identify relevant studies. Current in vitro studies have indicated that cranberry and/or its components may act as chemopreventive agents, diminishing the risk for cancer by inhibiting cells oxidation and inflammatory-related processes, while they may also exert chemotherapeutic effects by inhibiting cell proliferation and angiogenesis, inducing cell apoptosis and attenuating the ability of tumour cells to invade and metastasis. Limited in vivo studies have further documented potential anticancer activity. Cranberry could be considered as a conglomeration of potential effective anticancer druglike compounds.
Structural, Morphological, Vibrational, Thermal and Optical Properties of ZnS Quantum Dots in the Polymer Matrix
Authors: Mir Feroz A. , Mir Owais I. , Zargar Rayees A.
Published: July 2019

Background:

Nanotechnology is believed to be a future for new human generations.
Among different emerging materials, the Nanocomposites (NCs) would be on front line. The aim of
the current study is provide a way to synthesize the ZnS-polyacrylamide NCs with emphasis on the
effect of aging on polymer due to its various physical properties.

Objective:

To prepare and study the properties of ZnS-Polymer NCs with drying time in polymer
matrix.

Methods:

ZnS-polyacrylamide NCs samples were synthesized by adding aqueous suspension of ZnS
Nanoparticles (NPs) in Sol of acrylamide: bisacrylamide copolymer. These samples were characterized
by X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), thermogravimetric analysis
(TGA), Fourier transform infrared (FT-IR), UV-Vis, and Photoluminescence (PL) spectroscopy.

Results:

From XRD data analysis, nano phase and zinc blend structure of the material are confirmed.
From SEM images, the pristine ZnS NPs show spherical morphology, and this texture is still preserved
in the polymer composites. FT-IR confirms that there is a strong interaction between polymer
chain and ZnS NPs. The TGA results indicate that the incorporation of the NPs impacts the thermal
properties of the ZnS-polymer NCs and displays higher thermal stability than the pure polymer matrix.
The optical data predicts the band gap and Quantum Confinement Effect (QCE) and reduction of
ZnS NPs within the polymer matrix. These NCs show emission in blue region with decreases in intensity
with drying time.

Conclusion:

ZnS NPs incorporated in polyacrylamide were prepared by copolymer technique. Structural
analysis confirms zinc blend structure. The vibration spectra of composites samples predicts
an interaction between different functional groups of polymer with the metal sulfide. These NCs
show enhanced thermally stability. The observed optical band shows a red shift and quantum confinement
effect. The size calculated by XRD and optical data shows good correlation with each other.
The PL spectra of the NCs exhibits a broad blue emission with excitation (λex = 320 nm). The visible
region emission could be originated from the radiative recombination, involving defect states within
the ZnS nanocrystals energy band.
Dioses de la guerra y héroes grecorromanos en el primer pensamiento militar republicano neogranadino (1810-1816)
Authors: Del Molino García Ricardo
Published: July 2019

A pesar de haber sido obviada como objeto de estudio por las investigaciones sobre los procesos de tránsito del Antiguo Régimen a la Modernidad, así como en la tradición clásica y en la sensibilidad historiográfica del uso político de la historia, la antigüedad helena y latina estuvo presente en el pensamiento militar de la Primera República colombiana (1810-1819). A continuación, se mostrarán las fuentes que atestiguan su presencia, poniendo énfasis en los dioses de la guerra y héroes militares grecorromanos, y se procederá a su análisis con el fin último de poner en valor tanto la recepción y la apropiación del legado clásico en la Nueva Granada como la altura intelectual del primer pensamiento militar neogranadino.
Fístulas Digestivas
Authors: Moreira Gabriel Ramirez , Rodrigues Marco Antônio Gonçalves , Correia Maria Isabel Toulson Davisson
Published: July 2019

Fístulas digestivas são comunicações anormais entre  qualquer parte do trato gastrointestinal e outro órgão  interno ou a pele. Podem causar desequilíbrio hidroeletrolítico, déficits nutricionais, formação de  abscesso, infecção, sepse ou sangramentos. Existem várias maneiras de se classificar uma fístula gastrointestinal de acordo com sua anatomia, débito,  tempo de aparecimento, etiologia, entre outros. Os fatores de risco associados ao surgimento de fístulas digestivas são muitos e ainda em descoberta, sejam eles  locais ou sistêmicos. Sua fisiopatologia é complexa e as complicações de maior morbidade e mortalidade estão relacionadas à desnutrição e infecção. O tratamento deve ser multidisciplinar e adaptado a cada caso,  envolvendo medidas nutricionais, antimicrobianos, cuidados com a pele e, por vezes, cirurgia. Como o cirurgião desempenha papel fundamental na prevenção e tratamento das fístulas digestivas, este artigo pretende fazer revisão de conceitos fundamentais sobre o tema,  discutindo classificação, etiologia, fisiopatologia, complicações, diagnóstico e principais aspectos no manejo clínico, nutricional e cirúrgico.
Situation of Human Papilloma Virus: Generalities and current treatments
Authors: Preciado Cristhian , Vallejo Janeta Paolo
Published: July 2019

Human papillomavirus represents the commonest STD, and it is the principal causative agent of different genital lesions, including genital warts and cervical cancer. Two high-risk HPV genotypes are responsible for the 70% of cervical cancer, and the prevalence of these types reaches alarming levels in many developing countries (e.g., 43.58% in Ecuador). However, the information about HPV in developing countries is limited, becoming an obstacle for breakthrough treatments or prevention strategies. Current strategies include the development of new vaccines, combined chemo- and radiotherapy, and the use of CRISPR/Cas9. Moreover, HPV can be used to treat other non-related cancers, such as ovarian cancer. The present review aims to describe the different prevention strategies and treatments for HPV available worldwide, cover the usage of HPV for the treatment of other diseases, as well as comment on their possible application in Ecuador.
Quantification of fumonisins by the ELISA method in maize of different communities of the Cochabamba and Chuquisaca Departments
Authors: Torrico Torrico Stefania , Condori Vincenti Andrea , Angel Florido Miguel , Medrano Mercado Nora
Published: July 2019

Maize constitutes more than 75% of the food base of the Inter-Andean Valleys and is one of the foods most at risk of fumonisin and yet there is no information about the incidence level of fumonisins in this region. In this project we collected 174 samples from organic maize producers communities of the inter-Andean valleys that work with the Valles Foundation, the number of fumonisins was determined by the Elisa Method, with 0.05 ng/ml being the lowest value obtained in the community of Alcalá and 12.05 ng/ml,Highest value obtained in the community of Mizque.
Difference Between Users and Nonusers of a Patient Portal in Health Behaviors and Outcomes: Retrospective Cohort Study
Authors: Huang Jing , Chen Yong , Landis J Richard , Mahoney Kevin B
Published: July 2019

Background

Patient portals are frequently used in modern health care systems as an engagement and communication tool. An increased focus on the potential value of these communication channels to improve health outcomes is warranted.

Objective

This paper aimed to quantify the impact of portal use on patients’ preventive health behavior and chronic health outcomes.

Methods

We conducted a retrospective, observational cohort study of 10,000 patients aged 50 years or older who were treated at the University of Pennsylvania Health System (UPHS) from September 1, 2014, to October 31, 2016. The data were sourced from the UPHS electronic health records. We investigated the association between patient portal use and patients’ preventive health behaviors or chronic health outcomes, controlling for confounders using a novel cardinality matching approach based on propensity scoring and a subsequent bootstrapping method to estimate the variance of association estimates.

Results

Patient-level characteristics differed substantially between portal users, comprising approximately 59.32% (5932/10000) of the cohort, and nonusers. On average, users were more likely to be younger (63.46 years for users vs 66.08 years for nonusers), white (72.77% [4317/5932] for users vs 52.58% [2139/4068] for nonusers), have commercial insurance (60.99% [3618/5932] for users vs 40.12% [1632/4068] for nonusers), and have higher annual incomes (US $74,172/year for users vs US $62,940/year for nonusers). Even after adjusting for these potential confounders, patient portal use had a positive and clinically meaningful impact on patients’ preventive health behaviors but not on chronic health outcomes.

Conclusions

This paper contributes to the understanding of the impact of patient portal use on health outcomes and is the first study to identify a meaningful subgroup of patients’ health behaviors that improved with portal use. These findings may encourage providers to promote portal use to improve patients’ preventive health behaviors.
The Use of and Experiences With Telelactation Among Rural Breastfeeding Mothers: Secondary Analysis of a Randomized Controlled Trial
Authors: Kapinos Kandice , Kotzias Virginia , Bogen Debra , Ray Kristin , Demirci Jill , Rigas Mary Ann , Uscher-Pines Lori
Published: July 2019

Background

Telelactation services connect breastfeeding mothers to remotely located lactation consultants through audio-visual technology and can increase access to professional breastfeeding support in rural areas.

Objective

The objective of this study was to identify maternal characteristics associated with the demand for and use of telelactation and to describe visit characteristics.

Methods

We conducted a descriptive study within the context of a randomized controlled trial. Participant survey data and vendor electronic medical record data were used to assess video call characteristics like timing, duration, topics discussed, and participant satisfaction. Recruitment occurred from 2016-2018 at a rural critical access hospital in Pennsylvania. The 102 women enrolled in the study were given access to unlimited, on-demand video calls with lactation consultants through a mobile phone app and were tracked for 12 weeks following their postpartum hospitalization.

Results

A total of 94 participants out of 102 recruits (92%) participated in the final, 12-week survey assessment were included in the analysis. Of those, 47 (50%) participants reported participating in one or more video calls, and 31 (33%) completed one or more calls that included a substantive discussion of a breastfeeding challenge. Participants who used telelactation (21/31, 68%; P=.02) were more likely to be working at 12 weeks postpartum compared to others (26/63, 41%), were less likely (12/31, 39%; P=.02) to have prior breastfeeding experience on average compared to nonusers (41/63, 65%), and were less likely to have breastfed exclusively (16/31, 52%; P<.001) prior to hospital discharge compared to mothers who didn’t use telelactation services (51/63, 81%). Most video calls (58/83, 70%) occurred during the infant’s first month of life and 41% (34/83) occurred outside of business hours. The most common challenges discussed included: breast pain, soreness, and infection (25/83, 30%), use of nipple shields (21/83, 25%), and latch or positioning (17/83, 24%). Most telelactation users (43/47, 91%) expressed satisfaction with the help received.

Conclusions

Telelactation is an innovation in the delivery of professional breastfeeding support. This research documents both demand for and positive experiences with telelactation in an underserved population.

Trial Registration

ClinicalTrials.gov NCT02870413; https://clinicaltrials.gov/ct2/show/NCT02870413
Groundwater resources mapping for small island using Geoelectrical Technique the case study of Ternate Island
Authors: Hadi M. Pramono , Salam Ramdani , Achmad Rahim
Published: July 2019

The measurement of 2D geo-electrical using Wenner Alpha configuration was conducted in the shore line of northern part of Ternate island, in order to know the depth of interface and to analyze the aquifers in conjunction with estimation of ground water potential. Water quality analysis is also conducted in some dug wells, such as in situ water temperature, electrical conductivity, pH, turbidity, dissolved oxygen, and salinity.Due to laboratory analysis, the values of measured parameters of water quality from some dug wells meets to the standards referred, especially for drinking water. The result of interpretation from geo-electrical data showed the depth of interface less than 10m.  From a drilled well data near shore line, indicate about 5m deep of interface. Base on geo-electrical survey, water quality analysis and field observation can be concluded that Ternate Island has limited potential of ground water, especially related to amount of fresh ground water. Which is now days, no alternative source yet of clean water for domestic use.
Kontrol Pemuda Terhadap Tata Kelola Migas Dan Implikasinya Pada Ketahanan Wilayah Di Kawasan Migas Blok Cepu Kabupaten Bojonegoro
Authors: Wahyuhono Danang , Purwono Suryo , Mutiarin Dyah
Published: July 2019

ABSTRACTThis study aimed to analyzed form and capabilities of youth control, as well as to assessed their implications for regional resilience. Regional resilience was analyzed through the aspect of environmental, economic, social and security resilience, in which they were directly related to the oil and gas project activities in Cepu Block, namely Banyuurip area, Jambaran Tiung Biru area, and Pipe Line area. This study used qualitative methods, as it seeked to revealed the complex and deep social reality in the Cepu Block area. Using theory of access from Ribbot and Peluso (2003) which emphasized the ability of youth in controlling the flow of benefits and the impact of a resource. Control was defined as the ability to organized and directed relational actions. The flow of benefits and impacts were controlled in the form of employment benefits and Corporate Social Responsibility (CSR) programs, as well as environmental impacts. Youth had bundle of power to strengthened their control in the form of identity and social relations. This study revealed the diverse realities associated with youth control capabilities, and their implications for regional resilience. The most significant implications were environmental resilience, while economic, social, and security resilience were still vulnerable.ABSTRAKPenelitian ini bertujuan mengkaji bentuk dan kemampuan kontrol pemuda, serta implikasinya terhadap ketahanan wilayah. Ketahanan wilayah dikaji dalam gatra ketahanan lingkungan, ekonomi, sosial, dan keamanan. Penelitian ini menggunakan metode kualitatif, karena berupaya mengungkap realitas sosial yang kompleks dan mendalam di kawasan Blok Cepu. Kontrol pemuda dianalisis menggunakan teori akses dari Ribbot dan Peluso (2003) yang menekankan kemampuan pemuda dalam mengontrol aliran manfaat dan dampak dari suatu sumber daya.Kontrol didefinisikan sebagai kemampuan mengatur dan mengarahkan tindakan relasional. Aliran manfaat dan dampak yang dikontrol berupa manfaat pekerjaan dan program CSR, serta dampak lingkungan. Pemuda menggunakan ikatan kekuatan (bundle of power) untuk memperkuat kontrolnya, terutama berupa identitas dan relasi sosial. Penelitian ini mengungkap realitas yang beragam terkait kemampuan kontrol pemuda, dan implikasinya padaketahanan wilayah. Implikasi yang paling signifikan terdapat pada ketahanan lingkungan, sedangkan ketahanan ekonomi, sosial, dan keamanan masih bersifat rentan.
African Children’s Songs: A Legendary Teaching Tool
Authors: Holmes Dr. Gloria Kirkland
Published: July 2019

This paper presents a multicultural perspective of the historical and legendary analysis of African American children’s songs highlighting the important interpersonal familial relationships that have been noted teaching tools for African American children. The data includes multiple songs that have been used for generations to teach children values, history and cultural experiences with life enhancing strength and determination.These diverse experiences are characterized by historical practices that called for African American families to find multimodal means of teaching their children when it was against the law for African Americans to learn to read or to become educated.This research reveals that at various stages in the lives of African American children, parents and extended family members found ways to culturally educate their children. This was done through use of historical and generational African American songs and games. They have been instrumental in providing hope of a better life for those who were oppressed and often denied some of life’s inalienable rights.Teachers at all grade levels including ESL and Special Education could enhance children’s learning through use of multimodal thinking and learning activities.
Upholding the Honour of the Crown
Authors: McMorrow Thomas
Published: July 2019

In this paper, I aim to advance understanding of the constitutional principle of the honour of the Crown, by evaluating legal and political dimensions of the concept. I seek to demonstrate how the honour of the Crown may obscure but also illuminate legal issues and political challenges that meaningful pursuit of reconciliation involves.  I argue that once one starts to ask “Who is to uphold the honour of the Crown?” one observes opaque royal symbolism obscuring, but also framing, contested questions of governance shot through with collective coordination problems.  I argue that appreciating the normative potential of the “honour of the Crown” means acknowledging that the concept figures as but one of many communicative forms that may serve to foster a more just arrangement for and among peoples.
L’accès à la justice en contexte numérique : l’information juridique par et pour les justiciables sur les médias sociaux
Authors: Bahary-Dionne Alexandra
Published: July 2019

Au Québec et au Canada, l’accès à la justice est une préoccupation croissante pour les milieux juridique, politique et universitaire. L’inaccessibilité financière des services juridiques engendre plusieurs problèmes pour un nombre important de justiciables, tout comme l’inaccessibilité cognitive de l’univers juridique. C’est dans ce contexte que les technologies de l’information et de la communication [TIC] occupent une place importante dans les discussions sur les manières de rendre la justice plus accessible. Elles auraient notamment le potentiel de fournir des ressources plus intelligibles et accessibles aux justiciables. Les médias sociaux en particulier pourraient démocratiser l’information juridique dans la mesure où ils sont faciles d’utilisation, rassemblent une diversité de contenus et sont de plus en plus ancrés dans les activités quotidiennes. Malgré l’intérêt que suscitent ces plateformes sur le plan de l’accès à la justice, leurs usages relatifs à l’information juridique restent à explorer pour la recherche en droit. Le présent article s’intéresse à ces plateformes, et en particulier au média social Facebook, qui a pour particularité de mettre en scène des internautes qui sont à la fois créateurs, récepteurs et relayeurs de contenus d’information juridique. Nous proposons finalement une typologie utile à la recherche sur le thème du droit et des médias sociaux.
ENDOMETRITIS ULTRASOUND DIAGNOSIS: FEATURES OF BLOOD SUPPLY OF DIFFERENT MORPHOLOGICAL TYPES
Authors: Ozerskaya I. A. , Kazaryan G. G.
Published: July 2019

Aim. Despite significant advances in modern gynecology, endometritis is often unrecognized, being the main reason leading to persistent infertility or repeated pregnancy loss. There are 3 morphological types of chronic endometritis: hyperplastic, hypoplastic and mixed. The aim of the study was to develop ultrasound signs and hemodynamic features of various morphological types of chronic endometritis. Matherials and Methods. A retrospective analysis of 162 patients of reproductive age (22-50 years old) diagnosed with endometritis was carried out. The comparison group consisted of 96 women 17-42 years old without gynecological pathology (P > 0.05). The study was conducted in the proliferative phase of the cycle up to 10 days. The hemodynamics of the uterus and endometrium was evaluated on the basis of Doppler blood flow parameters in the uterine arteries, the calculation of arterial perfusion index (API), vascularization index (VI) and flow index (FI) of the uterus and endometrium obtained by 3D Doppler. Results. Depending on the morphotype of endometritis, hemodynamic features were evaluated. It was revealed that in the hypoplastic type, to which patients are related with the ratio of the endometrial volume to the volume of the uterus less than 2.5%, there is a significant (P < 0.05) decrease API, as well as hypovascularization of the uterus. Hypervascularization of the uterus and endometrium was observed both with a mixed morphotype, when the ratio of the endometrial volume to the volume of the uterus was from 2.5 to 9.0%, and in the case of a hyperplastic morphotype, when the volume of the endometrium to the volume of the uterus exceeded 9.0%. AIP was no different from healthy women. Conclusions. Diagnosis of impaired blood supply to the uterus will allow reasonable treatment and restore the reproductive function of women.
Pedagogical Content Knowledge, School Climate and Instructional Effectiveness of Secondary Schools Business Teachers in Ogun State, Nigeria
Authors: Bukki Abolaji O. , Dosunmu Margaret M. , Bukki Titilola O.
Published: July 2019

This research examined the relative influence of pedagogical content knowledge and school climate on instructional effectiveness of secondary schools business teachers in Ijebu Division, Ogun State, Nigeria. Descriptive survey design was adopted for the study. Pedagogical Content Knowledge Scale (PCKS), Organizational Climate Index (OCI) and Teacher Effectiveness Questionnaire (TEQ) were used as the instrument for data collection. The statistical method of analysis used for testing the raised questions were Simple percentage, Pearson Product Moment Correlation (PPMC) and Regression Analysis at 0.05 level of significance. The findings revealed that there was a positive relationship between pedagogical content knowledge, school climate and instructional effectiveness of secondary schools business teachers in Ijebu Division, Ogun State. Furthermore, pedagogical content knowledge, school climate significantly influenced the business teachers’ instructional effectiveness in secondary schools. It was recommended among others that principals should ensure that cooperative school climate that can inspire teachers to effectively fulfil their duties is created. The government should persuade and support business teachers to focus on conferences, workshops and seminars that will boost their pedagogical content knowledge in the fulfilment of their duties efficiently.
PENDIDIKAN DALAM PERSPEKTIF ISLAM DAN PERANANNYA DALAM MEMBINA KEPRIBADIAN ISLAMI
Authors: Hidayat Tatang , Rizal Ahmad Syamsu , Fahrudin Fahrudin
Published: July 2019

The presence of Islamic education is expected to be an alternative solution to educational problems caused by the materialism education system. This present study aims at investigating education from an Islamic perspective and its role in fostering Islamic personality. This study employed a qualitative approach and literature review method. Based on the results of the discussion, there has been no agreed term on education based on Islamic perspective. However, in this case, the writer is more inclined to ta'dÄb as the term for education in Islam since it, based on its conceptual structure, has included the elements of science (ilm), teaching (ta'lÄ«m), and good care (tarbiyaÄ§). The purposes of Islamic education are to develop an Islamic personality and to master Islamic safaqah, science and technology, and adequate expertise. In Islam, teachers are regarded as a highly honored person, and students are encouraged to maintain good character and conduct (adab) when they interact with their teachers. In addition, Islamic curriculum and education materials are supposed to be in line with the Islamic Aqeedah (faith). In principle, Islamic education methods have their own characteristics and one of them is the Quranic education method. All media and facilities are permissible as long as it does not conflict with the Islamic Aqeedah (faith). The evaluation in Islamic education consists of measurements and assessments covering the aspects of aqliyah, qolbiyah, and amÄliyah. Islamic education plays an important role in fostering Islamic personality since it is inseparable from the idea of Islamic education in order to foster an Islamic personality.
PENERAPAN METODE BILHIKMAH, MAU’IZATULHASANAH, JADIL DAN LAYYINAH PADA BALAI DIKLAT KEAGAMAAN ACEH
Authors: Nurdin Nurdin
Published: July 2019

The Qur'an and the Hadith of the Messenger of Allah (SAW) if examined carefully will be found in many ways, processes, techniques, strategies or methods that are very effective to be applied in the world of education, so that it will produce a generation of the style of Qur'an and in the style of the Messenger of Allah. But unfortunately educators and leaders today rarely involve themselves studying the verses of Al-Qur' an and the Sirah of the Messenger of Allah SAW related to various methods that he has applied in guiding his community except for only a small part. Whereas in Al-Quran there are several methods of teaching and educating that are very effective and efficient to be implemented at this time, this method has been proven to produce millions of ummah accepting Islam for the invitation of the Messenger of Allah, namely through the Bilhikmah method, Al-Mau'izah Hashanah, Al-Jadil and Al-Layyinah as described in the Qur'an letter An-Nahl verse 125. This writing aims to reveal how the learning process in the Aceh training center. The method used is descriptive with a library research approach and study of the results of field research.
COMPETITIVIDADE DAS EXPORTAÇÕES BRASILEIRAS DE BANANA
Authors: Santos José Lucas da Silva , Sousa Eliane Pinheiro de
Published: July 2019

Este estudo busca analisar a competitividade das exportações de banana proveniente dos estados do Ceará, Paraná, Rio Grande do Norte, Rio Grande do Sul e Santa Catarina no período de 2003 a 2017 por meio dos indicadores de desempenho. Para atender esse objetivo p, empregaram-se os índices de vantagem comparativa revelada de Balassa (IVCR), vantagem comparativa revelada simétrica (IVCRS) e vantagem comparativa revelada de Vollrath (RCAV). Utilizou-se também o modelo Constant Market Share para identificar as fontes de crescimento das exportações brasileiras de banana, considerando três subperíodos: 2003-2007, 2008-2012 e 2013-2017. Os dados foram extraídos da Secretaria de Comércio Exterior (SECEX), órgão vinculado ao Ministério do Desenvolvimento, Indústria e Comércio Exterior (MDIC). Os resultados mostram que os estados do Rio Grande do Norte e de Santa Catarina registraram vantagem comparativa em relação ao Brasil, enquanto o estado do Paraná apresentou desvantagem comparativa nas exportações de banana durante todo o período considerado, conforme o IVCR, o IVCRS e o RCAV. Com base nesses três índices analisados, verifica-se a presença de vantagem comparativa nas exportações de banana para o estado do Ceará a partir de 2006 e para o estado do Rio Grande do Sul de 2012 a 2015. Ademais, constata-se que o efeito destino das exportações foi o que mais contribuiu nas exportações da commodity analisada quando se compara o segundo subperíodo com o primeiro e o terceiro com o segundo, enquanto que o efeito competitividade foi determinante apenas no terceiro subperíodo quando comparado com o segundo.
Contraceptive Care for Women With Medical Conditions: A Qualitative Study to Identify Potential Best Practices for Primary Care Physicians
Authors: Kang Minji Michelle , Guetterman Timothy C. , Prussack Julie K. , Ursu Allison , Wu Justine P.
Published: July 2019

Background and Objectives: Women with medical conditions are at higher risk of pregnancy-related morbidity and mortality than women without medical conditions. Thus, women who do not desire pregnancy should be offered contraceptive counseling and methods. The objective of this qualitative study was to identify potential best practices to guide primary care physicians (PCPs) in providing contraception and contraceptive counseling for women with medical conditions.
Methods: We conducted semistructured qualitative interviews of 10 PCPs who routinely provide contraception including long-acting reversible contraception (LARC). To inform the data collection and analysis, we adapted constructs from the Theoretical Domains Framework. We coded transcripts and identified themes until saturation of our theoretical constructs was achieved.
Results: Physician time constraints, lack of patient knowledge, and competing demands related to medical condition management were identified as barriers to contraceptive care. The study participants reported multiple strategies to mitigate these barriers. They emphasized providing reproductive health education in the context of an individual’s chronic conditions and medications, educating about LARC methods, and using the US Medical Eligibility Criteria (US MEC) as a point-of-care clinical tool to guide contraceptive selection.
Conclusions: The study participants (PCPs experienced in contraceptive care), described multifaceted approaches to providing contraception for women with medical conditions, including tailored contraceptive education and use of the US MEC for clinical guidance. Future research is needed to assess if such strategies can improve patient outcomes and be adopted by PCPs who have less experience with contraceptive care.
Whither Family Medicine? Our Past, Future, and Enduring Scope of Practice
Authors: Loxterkamp David
Published: July 2019

After 3 decades in private practice, I joined the faculty of a nearby residency program. Like most family medicine residencies, it follows a curriculum that my physician father would have recognized: heavy emphasis on inpatient medicine; short shrift to continuity care. Despite a changing marketplace, there is still a disconnect between how we train graduates (for full spectrum care) and where they end up (in ambulatory practices). Is our identity disappearing? I contend that the primary and indispensable duty of a residency program is to model professional values and prepare residents to live and work in sustainable communities. Though the scope of practice will vary, family physicians still pride themselves in putting the needs of their patients at its center.
Breastfeeding During Family Medicine Residency
Authors: Al-Imari Lina , Hum Susan , Krueger Paul , Dunn Sheila
Published: July 2019

Background and Objectives: Canadian residents’ breastfeeding experiences have only been reported in studies that broadly explored pregnancy and parenthood. We sought to fully explore Canadian family medicine resident mothers’ breastfeeding experiences, and identify strategies to support workplace breastfeeding for future trainees.
Methods: Using an online survey, University of Toronto family medicine residents who gave birth from 2010 through 2016 were queried about their exclusive and overall breastfeeding duration, barriers, and facilitators to workplace breastfeeding, and strategies to improve the breastfeeding experience for future resident mothers. Data were downloaded from Qualtrics software and descriptive statistical analyses were conducted using IBM SPSS Statistics v.24.0. Subjective comments were examined and linked to quantitative findings.
Results: Fifty-six of 179 eligible residents completed the survey (31% response rate). More than three-quarters of residents were on maternity leave for 7 to 12 months. All initiated breastfeeding, and 54% breastfed exclusively for 6 months. The median breastfeeding duration was 10 to 12 months. Almost two-thirds of residents were breastfeeding upon return to work, and all experienced barriers to workplace breastfeeding including lack of time, private space, and refrigeration for expressed milk. Lack of a workplace breastfeeding policy and inadequate support from supervisors or program directors were additional barriers. Peer mentorship and more breastfeeding education were identified as strategies to support future residents’ breastfeeding goals.
Conclusions: Addressing long-standing barriers to workplace breastfeeding, and providing peer and educational supports were identified as strategies that could inform program policies to support future trainees’ breastfeeding goals and experiences.
About estimation of base station output power in GSM like systems under real conditions
Authors: Lebl Aleksandar , Mitic Dragan , Markov Zarko , Vasiljevic Verica
Published: July 2019

The output power of traffic channels in one cell of GSM like systems is
estimated in this paper. We consider the real case: the number of users is
much higher than the number of channels, the output power of one channel
depends on the cube of the distance between a mobile user and the base
station, and the distribution of users in the cell is uniform. We derive the
expressions for cumulative distribution of output power of one channel and
for the mean output power of the whole base station. Results of the
calculation are confirmed by computer simulation.
Enhancing The Speaking Performance Of Efl College Students Through Video Projects
Authors: Hasanah Yuli Astuti
Published: July 2019

The study described how video projects were used to enhance the speaking performance of EFL college students in IAIN Kediri, Indonesia. The researcher found that students faced technical and personal problems appeared in the speaking class. A classroom action research was applied to the study to solve the problems. Then, the data was analyzed descriptively. The result of the study identified that students emerged confidence, fluency, good collaboration and excitement in the speaking class. The study resulted that obstacles of speaking English can be solved alternatively through the used of song videos as the project by practicing the aspects of the language in song lyrics and producing videos which then were spread out through YouTube website in order to appreciate their work and creativity as well as to share it as useful sources of teaching media and also entertainment.