bluuebunny/crossref_metadata_2025 huggingface dataset:
25 au Angular Resolution Observations of HH 211 with ALMA: Jet Properties and Shock Structures in SiO, CO, and SO
Authors: Jhan Kai-Syun , Lee Chin-Fei
Published: March 2021

HH 211 is a highly collimated jet with a chain of knots and a wiggle structure on both sides of a young Class 0 protostar. We used two epochs of Atacama Large Millimeter/submillimeter Array (ALMA) data to study its inner jet in the CO(J = 3–2), SiO(J = 8–7), and SO(N

J
= 89–78) lines at ∼25 au resolution. With these ALMA and previous 2008 Submillimeter Array data, the proper motion of 8 knots within ∼250 au of the central source is found to be ∼0068 per year (∼102 km s−1), consistent with previous measurements in the outer jet. At about four times higher resolution, the reflection-symmetric wiggle can be still fitted by a previously proposed orbiting jet source model. Previously detected continuous structures in the inner jet are now resolved, containing at least 5 subknots. These subknots are interpreted in terms of a variation in the ejection velocity of the jet with a period of ∼4.5 yr, shorter than that of the outer knots. In addition, backward and forward shocks are resolved in a fully formed knot, BK3, and signatures of internal working surface and sideways ejection are identified in position–velocity diagrams. In this knot, low-density SO and CO layers are surrounded by a high-density SiO layer.
Neoadjuvant Chemotherapy Effect on Predictive Value of Sentinel Lymph Node Biopsy using Single Method Methylene Blue in Breast Cancer Patients at Low-resource Country
Authors: Putra Muhammad David Perdana , Yarso Kristanto Yuli , Wasita Brian
Published: March 2021

AIM: This study aimed to examine the application of neoadjuvant chemotherapy (NAC) effect on sentinel lymph node biopsy (SLNB) using single method methylene blue 1% in breast cancer patients at low-resource country.
METHODS: This analytical observational study employed a retrospective case–control approach. The total sampling method was used by involving the entire population of Stage-I and -II breast cancer patients after performed core biopsy or open biopsy with clinically negative axillary lymph nodes that had performed SLNB and axillary lymph nodes dissection at several hospitals in Surakarta from January to May 2020. The descriptive data were presented in the frequency table. Sensitivity, specificity, positive predictive value, negative predictive value (NPV), and diagnostic values were reported with 95% confidence of interval (CI).
RESULTS: From a total of 161 patients, 100 patients were given NAC. The identification rate of the non-NAC was 91.3% and the NAC group 80.6%. Non-NAC group obtained a false-negative rate of 24.4% with NPV of 94.4% (95% CI 85–100), while the false-negative rate of the NAC group was 10.8% with NPV of 74% (95% CI 65–80).
CONCLUSIONS: NAC with single method methylene blue 1% injection in SLNB can reduce the identification and false-negative rates in breast cancer patients.
Strengthening Community-based Surveillance Cadre Activeness through Interpersonal Communication and Module Development in Barru District
Authors: Zulkifli Andi , Sidin Andi Indahwaty , Nasrah Nasrah , Rahmah Siti , Fitri A. Ulfiana
Published: March 2021

BACKGROUND: The low activity of community-based surveillance (CBS) cadres reflects the inadequate implementation of the CBS program. It can hinder the CBS program’s success.
AIM: This study aimed to increase the activeness of CBS cadres through interpersonal communication and module development.
METHODS: This research was a quasi-experimental research with the non-randomized pre-test and post-test control group design. This study’s population was all 48 cadres of CBS. They were not active in several subdistricts, including Tanete Riaja subdistrict, Barru subdistrict, Balusu subdistrict, and Mallusetasi subdistrict. The intervention sample was 20 people in the Tanete Riaja subdistrict. The control sample was 20 people scattered in the subdistricts of Barru, Balusu, and Mallusetasi, obtained by purposive sampling. Data analysis used the Chi-square test.
RESULTS: There are differences in the increase before and after the interpersonal communication intervention and module development, from 0% to 65%. There was a difference in increasing activeness in the interpersonal communication intervention group and module development compared to the control group, which was only given module development (0.011).
CONCLUSION: There were differences in the increased activity before and after interpersonal communication intervention and module development. There was a higher increase in the interpersonal communication intervention group and module development than only module intervention. It is suggested that the health office provides modules and interpersonal communication training to CBS cadres.
Platelet Augmentation Potential of Polyherbal Formulation in Cyclophosphamide-Induced Thrombocytopenia in Wistar Rats
Authors: Sailor Girish , Hirani Komal , Parmar Ghanshyam , Maheshwari Rajesh , Singh Rupa , Kumar Seth Avinash
Published: March 2021

Introduction: Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as platelets, in the blood. Several medicinal plants possess curative and protective effect against thrombocytopenia associated with diseases or drugs.

Aim: In the present study, we have investigated the platelet augmentation activity of polyherbal formulation (VITA PLAT Capsule) in cyclophosphamide-induced thrombocytopenic rat model. 

Materials and methods: Twenty-four albino Wistar rats were divided into four groups. Thrombocytopenia was induced in the rats by administering cyclophosphamide (25 mg/kg, i.p.) for three days to all the groups except normal controls. The test groups were given orally a polyherbal formulation suspended in normal saline for 14 days. Blood was withdrawn from the retro-orbital plexus of the rats on days 1, 7, and 14 of study to determine platelet counts in all groups. Clotting time and bleeding time were determined on the last day of study. Data were collected and analyzed using GraphPad Prism 8. 

Results: The results showed that the polyherbal formulation treatment could significantly ameliorate platelet count in thrombocyto-penic rats in the initial as well as in the later phase. The total WBC count was also improved during later phase in test groups. However, there is no significant difference between clotting time and bleeding time in all groups. 

Conclusions: Our study suggests a potential role of this formulation in the augmentation of platelet counts in various thrombocyto-penic disorders including a role in ameliorating the haemorrhagic complications of dengue fever.
Microwave and Conventional Study of Coumarin-Oxadiazole Adducts and their Anti-Microbial Evaluation
Authors: Kapadiya Khushal , Dholaria Piyush
Published: March 2021

Introduction: Nowadays, researchers are progressively concentrated to generate economical, affordable and also greener synthesis approach for the synthesis of various heterocycles. On look at the beauty of coumarin molecules and oxazoles, it seems to be lead  molecules in the anti-microbial area. 

Aim: With the target to identify efficient molecules, we studied 2-oxo-2H-chromen-4-yl-2-((5-substituted aryl-1,3,4-oxadiazol-2-yl) thio)acetate derivatives using two synthetic protocol/methods, i.e. conventional synthesis and microwave-based synthesis.

Materials and methods: Two simultaneous methods, i.e. conventional and microwave synthesis have been used for the synthe-sis of 2-oxo-2H-chromen-4-yl-2-((5-substituted aryl-1,3,4-oxadiazol-2-yl)thio)acetate (6a-l) derivatives. The desired molecules were synthesized by conventional and microwave synthesis and a comparative study was carried out to identify an easy route for industrial applications. The confirmations of the compounds were carried out by spectroscopic techniques such as IR, 1H NMR, 13C NMR, mass spectra and elemental analysis. 

Results: All synthesized compounds were evaluated for their in-vitro antibacterial activity against gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenes), gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and antifungal activity (Candida albicans, Aspergillus niger). 

Conclusions: All conventional synthesis of final coumarin derivatives were completed within 4-6 h. While that of microwave-based reaction took comparatively more reaction time. Surprisingly, the compounds 6f and 6g could not be synthesized by microwave radiation even after 32 minutes of irradiation. As to the medicinal application part, microbial evaluation of synthesized analogues showed that the compounds 6b, 6e, 6d, and 6j were found more potent in comparison to the reference drug. 
Tunnelled hemodialysis catheter-related bloodstream infection with Ochrobactrum anthropi: a report of the first two cases from Bulgaria and a brief overview
Authors: Borisov Biser K. , Hitkova Hristina Y. , Linkova Stela P.
Published: March 2021

The use of central venous catheters for hemodialysis continues to grow worldwide, despite the efforts of many specialists. Patients with end-stage renal disease have impaired immunity, which is why infections are the most common complication seen in them. It worsens their quality of life and is a major cause of high morbidity and mortality, especially in hemodialysis patients.

We report two cases of catheter-related bloodstream infection in hemodialysis patients caused by Ochrobactrum anthropi, which are the first reported cases in Bulgaria and present a brief literature review of the known facts.
Efficacy and safety of Aviron Rapid® in 18-60-year-old patients with clinical diagnosis of acute respiratory viral infection: a multicenter, randomized, double-blind, placebo-controlled clinical trial
Authors: Popov Georgi , Gospodinova-Bliznakova Margarita , Kalvatchev Zlatko , Tchorbanov Andrey
Published: March 2021

Aim: Prevention and treatment of upper respiratory tract infections are given the highest priority because of the tremendous health and economic impact of these diseases. Development of novel effective and safe options for treatment can contribute considerably to decrease the burden of disease.

Materials and methods: We designed a multicenter, randomized, double-blind, placebo-controlled study in ambulatory-treated adult patients with a clinical diagnosis of acute upper respiratory tract viral infection. The patients (18-60 years old) were randomized into two groups and followed-up for 5 days. Group 1 received the standard symptomatic therapy + Aviron Rapid®, and Group 2 received the standard symptomatic therapy + placebo. The primary endpoint of the study was defined as the duration of disease measured by the percentages of disease-free patients for every 12-hour period of the study. 

Results: Treating clinically relevant patients with the natural product Aviron Rapid® for 5 days decreases the duration of disease, the intake of antipyretics and the severity of symptoms. Significant difference between the tested groups for most of studied parameters was found as soon as 12 or 24 hours after initiation of administration in favour of active arm and was the most prominent on days 3 and 4. Significant decrease in the total score of symptoms severity was achieved on day 4 and extended to the end of study. There were no dif-ferences in the adverse events between the groups and the tested product demonstrated excellent safety profile. 

Conclusions: This study is a clinical confirmation of well documented antiviral activity of the product targeting multiple points in viral replication and covering broad spectrum viral pathogens.
Updates on Axial Psoriatic Arthritis From the 2020 GRAPPA Annual Meeting
Authors: Gladman Dafna D. , Helliwell Philip S. , Poddubnyy Denis , Mease Philip J.
Published: March 2021

This article summarizes sessions that dealt with axial psoriatic arthritis (axPsA) at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2020 virtual meeting. The summary includes the symposium, which comprised a plenary presentation by Dr. Dafna Gladman from Toronto, Canada, as well as a panel discussion with Dr. Philip Helliwell, Dr. Denis Poddubnyy, and Dr. Gladman, moderated by Dr. Philip Mease. In addition, the paper also summarizes Dr. Mease’s “Meet the Expert” session, which focused on axPsA.
Composite Measures for Routine Clinical Practice in Psoriatic Arthritis:
Testing of Shortened Versions in a UK Multicenter Study
Authors: Tillett William , FitzGerald Oliver , Coates Laura C. , Packham Jon , Jadon Deepak R. , Massarotti Marco , Brook Mel , Lane Suzanne , Creamer Paul , Antony Anna , Korendowych Eleanor , Rambojun Adwaye , McHugh Neil J. , Helliwell Philip S.
Published: March 2021

Objective

To test shortened versions of the psoriatic arthritis (PsA)
composite measures for use in routine clinical practice.

Methods

Clinical and patient-reported outcome measures (PROMs) were
assessed in patients with PsA at 3 consecutive follow-up visits in a UK
multicenter observational study. Shortened versions of the Composite
Psoriatic Arthritis Disease Activity Index (CPDAI) and Group for
Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)
Composite Exercise (GRACE) measures were developed using PROMs and
tested against the Disease Activity Score in 28 joints (DAS28),
composite Disease Activity in Psoriatic Arthritis, and Routine
Assessment of Patient Index Data (RAPID3). Discrimination between
disease states and responsiveness were tested with the
t-score, standardized response mean
(SRM), and effect size (ES). Data were presented to members at the
GRAPPA 2020 annual meeting and members voted on the recommended
composite routine practice.

Results

The SRM for the GRACE, 3 visual analog scale (VAS), and 4VAS were
0.67, 0.77, and 0.63, respectively, and for CPDAI and shortened CPDAI
(sCPDAI) were 0.54 and 0.55, respectively. Shortened versions of the
GRACE increased the t-score from 7.8 to 8.7
(3VAS) and 9.0 (4VAS), but reduced the
t-score in the CPDAI/sCPDAI from 6.8 and 6.1.
The 3VAS and 4VAS had superior performance characteristics to the
sCPDAI, DAS28, Disease Activity in Psoriatic Arthritis, and RAPID3 in
all tests. Of the members, 60% agreed that the VAS scales contained
enough information to assess disease and response to treatment, 53%
recommended the 4VAS for use in routine care, and 26% the 3VAS, while
leaving 21% undecided.

Conclusion

Shortening the GRACE to VAS scores alone enhances the ability to
detect status and responsiveness and has the best performance
characteristics of the tested composite measures. GRAPPA members
recommend further testing of the 3VAS and 4VAS in observational and
trial datasets.
Monitoring Programs for Nurses With Substance Use Disorders: One Nurse's Journey and Recommendations
Authors: Shuster Rachel
Published: March 2021

Estimates of nurses with substance use disorders (SUDs) are approximately equal to those of the general public. Historically, nurses with SUDs faced public disciplinary action for any violations of the nurse practice act in their respective states, but now many states have alternative-to-discipline (ATD) programs available. Although the consent agreement for disciplinary and non-disciplinary programs are often similar, ATD programs are, in contrast, confidential and assist nurses to safely return to practice. As a RN and person in long-term recovery, I have first-hand experience with an ATD program. I credit the program with saving my career; however, it is not without criticism. Recommendations for improvements include increased education about ATD programs, research to evaluate efficacy of mandated interventions, including nurses in recovery within shared governance of these programs, implementing true peer support with nurses in long-term recovery, defraying the costs of the program to participants, and ensuring all staff within the programs receive standardized onboarding training followed by ongoing education. [
Journal of Psychosocial Nursing and Mental Health Services, 59
(3), 13–17.]
Estimation of Soil Erosion in Three Northern Regions of Ghana Using RUSLE in GIS Environment
Authors: Salifu Eliasu , Agyare Wilson Agyei , Kyei-Baffour Nicholas , Dumedah Gift
Published: March 2021

Soil erosion is a global problem with severe consequences, which has become a widespread environmental challenge in the northern parts of Ghana in recent times. This research integrated RUSLE into GIS to estimate the annual soil erosion rates for the Northern, North-East, and Savannah Regions of Ghana. A soil erosion map was generated with an annual soil erosion rate of 4.0 t ha−1y−1 for the Northern Region, 5.0 t ha−1y−1 for the North-East Region, and 7.0 t ha−1y−1 for the Savannah Region. Relatively higher erosion rates were observed in the Tatale Sangule and Kpandai districts of the Northern Region, with rainfall erosivity being the main driving factor. There was a landuse/cover erosion reduction effect of 66% in the Northern Region, 70% in the Northeast Region, and 58% in the Savannah Region. The cover management (C) factor was overwhelmingly the main erosion-reducing factor in erosion control as opposed to land conservation (P) factor.
The Use of Communication Strategies in Mobile Asynchronous Chat
Authors: Chai Xun Yu , Subramaniam Ganakumaran
Published: March 2021

The 21st century education is to provide students with digital learning experiences alongside creating a path to independent and collaborative learning. In this regard, computer-mediated communication (CMC) is receiving great attention in the field of education. Using a case study mixed methods approach, this paper examines the communication strategies used by postgraduate students, who are also in-service teachers, using the asynchronous WeChat mobile app for academic problem-solving purposes. It also explores their opinions on the practicality of using the oral asynchronous communication programme for problem-solving activities. It is found that the asynchronous spoken medium triggers ‘presentation speech' patterns that reflect both spoken and written features. The problem-solving process in the asynchronous spoken medium also is mediated via a low frequency of the use of communication strategies. The findings shed light on teaching and learning via oral-based asynchronous medium pertaining to the types of tasks and learning objectives to be achieved.
Unemployment, Personality Traits, and the Use of Facebook
Authors: Ukpabi Dandison C. , Olawumi Olayemi , Balogun Oluwafemi Samson , Nwachukwu Chijioke E. , Sunday Adewale Olaleye  , Kolog Emmanuel Awuni , Agjei Richard O. , Adusei-Mensah Frank , Awoniyi Luqman , Atsa'am Donald Douglas , Adeyemi Oluwafikayo
Published: March 2021

Different personality traits respond differently to unfavourable life situations. Unemployment can have several negative social, economic, and domestic consequences. Many people use social media for a variety of reasons. The aim of this study is to examine the way different personality traits respond to Facebook in the period of unemployment. Data was obtained from 3,002 unemployed respondents in Nigeria. The study used regression model to analyse the data. Among the five personality traits, results indicated that the relationship between neuroticism and online social support was negative. However, the relationship between online social support and satisfaction was positive. The study highlights several theoretical and practical implications.
Daytime-to-Nighttime Sleep Ratios and Cognitive Impairment in Older Intensive Care Unit Survivors
Authors: Elías Maya N. , Munro Cindy L. , Liang Zhan
Published: March 2021

Background

Sleep duration and proportion of daytime versus nighttime sleep may affect cognitive function in older patients in the transition out of the intensive care unit.

Objective

To explore the relationship between the daytime-to-nighttime sleep ratio and cognitive impairment in older intensive care unit survivors.

Methods

The study enrolled 30 older adults within 24 to 48 hours after intensive care unit discharge. All participants were functionally independent before admission and underwent mechanical ventilation in the intensive care unit. Actigraphy was used to estimate daytime (6 AM to 9:59 PM) and nighttime (10 PM to 5:59 AM) total sleep duration. Daytime-to-nighttime sleep ratios were calculated by dividing the proportion of daytime sleep by the proportion of nighttime sleep. The National Institutes of Health Toolbox Cognition Battery Dimensional Change Card Sort Test (DCCST) was used to assess cognition. Associations between sleep and cognition were explored using multivariate regression after adjusting for covariates.

Results

The mean (SD) daytime sleep duration was 7.55 (4.30) hours (range, 0.16-14.21 hours), and the mean (SD) nighttime sleep duration was 4.99 (1.95) hours (range, 0.36-7.21 hours). The mean (SD) daytime-to-nighttime sleep ratio was 0.71 (0.30) (range, 0.03-1.10). Greater daytime sleep duration (β = −0.351, P = .008) and higher daytime-to-nighttime sleep ratios (β = −0.373, P = .008) were negatively associated with DCCST scores.

Conclusions

The daytime-to-nighttime sleep ratio was abnormally high in the study population, revealing an altered sleep/wake cycle. Higher daytime-to-nighttime sleep ratios were associated with worse cognition, suggesting that proportionally greater daytime sleep may predict cognitive impairment.
Manual vs Automatic Prone Positioning and Patient Outcomes in Acute Respiratory Distress Syndrome
Authors: Morata Lauren , Sole Mary Lou , Guido-Sanz Frank , Ogilvie Carrie , Rich Rebecca
Published: March 2021

Background

Prone positioning is a standard treatment for moderate to severe acute respiratory distress syndrome (ARDS), but the outcomes associated with manual versus automatic prone positioning have not been evaluated.

Objective

To retrospectively evaluate outcomes associated with manual versus automatic prone positioning as part of a pronation quality improvement project implemented by a multidisciplinary team.

Methods

A retrospective, descriptive-comparative approach was used to analyze data from 24 months of a prone positioning protocol for ARDS. The study involved 37 patients, with 16 undergoing manual and 21 undergoing automatic prone positioning. Descriptive and nonparametric statistical analyses were used to evaluate outcomes associated with manual versus automatic prone positioning.

Results

Outcomes were similar between the 2 groups regarding time to initiation of prone positioning, discharge disposition, and length of stay. Manually pronated patients were less likely to experience interruptions in therapy (P = .005) and complications (P = .002). Pressure injuries were the most common type of complication, with the most frequent locations in automatically pronated patients being the head (P = .045), thorax (P = .003), and lower extremities (P = .047). Manual prone positioning resulted in a cost avoidance of $78 617 per patient.

Conclusion

Manual prone positioning has outcomes similar to those of automatic prone positioning with less risk of interruptions in therapy, fewer complications, and lower expense. Further research is needed to determine whether manual prone positioning is superior to automatic prone positioning in patients with ARDS.
Key Elements of the Critical Care Work Environment Associated With Burnout and Compassion Satisfaction
Authors: Kelly Lesly A. , Johnson Karen L. , Bay R. Curtis , Todd Michael
Published: March 2021

Background

As the role of a health care system’s influence on nurse burnout becomes better understood, an under-standing of the impact of a nurses’ work environment on burnout and well-being is also imperative.

Objective

To identify the key elements of a healthy work environment associated with burnout, secondary trauma, and compassion satisfaction, as well as the effect of burnout and the work environment on nurse turnover.

Methods

A total of 779 nurses in 24 critical care units at 13 hospitals completed a survey measuring burnout and quality of the work environment. Actual unit-level data for nurse turnover during a 5-month period were queried and compared with the survey results.

Results

Among nurses in the sample, 61% experience moderate burnout. In models controlling for key nurse characteristics including age, level of education, and professional recognition, 3 key elements of the work environment emerged as significant predictors of burnout: staffing, meaningful recognition, and effective decision-making. The latter 2 elements also predicted more compassion satisfaction among critical care nurses. In line with previous research, these findings affirm that younger age is associated with more burnout and less compassion satisfaction.

Conclusions

Efforts are recommended on these 3 elements of the work environment (staffing, meaningful recognition, effective decision-making) as part of a holistic, systems-based approach to addressing burnout and well-being. Such efforts, in addition to supporting personal resilience-building activities, should be undertaken especially with younger members of the workforce in order to begin to address the crisis of burnout in health care.
Rapid Mortality Review in the Intensive Care Unit: An In-Person, Multidisciplinary Improvement Initiative
Authors: Schwab Kristin E. , Simon Wendy , Yamamoto Myrtle , Dermenchyan Anna , Xu Xueqing , Kao Yuhan , Zider Alexander , Shaikh Faisal , Garber Bryan , Lee Elinor , Anklesaria Zafia , Nelson G. Sofia , Ramsey Allison , Neville Thanh H.
Published: March 2021

Background

Significant resources have been allocated to decreasing the number of preventable deaths in hospitals, but identifying preventable factors and then leveraging them to effect system-wide change remains challenging.

Objective

To determine the ability of a novel in-person, multidisciplinary “rapid mortality review” process to identify deaths that are preventable and action items that lead to improvements in care.

Methods

Rapid mortality review sessions were conducted weekly for patients who died in the medical intensive care unit. Patient data and clinician opinions regarding preventable deaths were discussed and recorded. Bivariate analyses were done to detect associations between case variables and the formation of an action item.

Results

From 2013 to 2018, 542 patient deaths were reviewed; of those, 36 deaths (7%) were deemed potentially preventable. Facilitators identified issues in 294 cases (54%). A total of 253 action items were identified for 175 cases (32%); 60% of those action items were subsequently completed and led to tangible systemic change in 29 instances (11%). Action items were more likely to be identified for patients who had not been receiving comfort care (P < .001), for patients who had received cardiopulmonary resuscitation (P < .001), when the treatment team (P < .001) or the rapid mortality review facilitator (P < .001) had care-related concerns, and when the patient’s death had been preventable (P < .001).

Conclusions

Even in settings with low reported rates of preventable deaths, an in-person multidisciplinary mortality review can successfully identify areas where care can be improved, leading to systemic change.
The effects of Benjakul extract and its isolated compounds on cell cycle arrest and apoptosis in human non-small cell lung cancer cell line NCI-H226
Authors: Itharat Arunporn , Rattarom Ruchilak , Hansakul Pintusorn , Sakpakdeejaroen Intouch , Ooraikul Buncha , Davies Neal M.
Published: March 2021

Background and purpose:

Benjakul, a traditional Thai formulation for cancer treatment, is composed of five plants. This study aimed to assess the cytotoxicity of Benjakul, its five plants, and its isolated compounds against non-small cell lung cancer (NSCLC) by the sulforhodamine B (SRB) assay.

Experimental approach:

Analyses of cell cycle and membrane asymmetry changes were performed with different fluorescent dyes and analyzed by flow cytometry in NCI-H226 cells. Activation of caspase-3 was measured using a caspase-3 colorimetric assay kit. The pan-caspase inhibitor Z-VAD-FMK was used in analyses of cell cycle and caspase-3 activity.

Findings/Results:

Benjakul exhibited cytotoxicity against NSCLC with IC50 between 5.56-5.64 μg/mL. Among its five ingredients, Benjakul displayed the highest selectivity with selectivity index values ranging from 2.93 to 6.88, with the exception of Plumbago indica, indicating its protective effects. Plumbagin and 6- shogaol displayed the highest cytotoxicity and underwent molecular studies in NCI-H226 cells. Flow cytometry analysis revealed that Benjakul and 6-shogaol dose-dependently induced G2/M phase arrest, and plumbagin dose-dependently induced S-G2/M phase arrest with the highest percentage in early incubation time (12-24 h). At the highest doses, Benjakul extract, 6-shogaol, and plumbagin time-dependently increased the population of sub-G1 apoptotic cells with the highest percentage in longer incubation time (60-72 h). Similarly, membrane asymmetry changes showed time-dependent increases in the percentage of early and late apoptotic cells. Moreover, the apoptosis-inducing effect of Benjakul, 6-shogaol, and plumbagin at the highest dose, via the caspase cascade was confirmed by time-dependent induction of caspase-3 activity, followed by its complete reduction and abolished sub-G1 peaks upon addition of Z-VAD-FMK.

Conclusion and implication:

Our findings demonstrated for the first time the effects of Benjakul and its compounds on S-G2/M or G2/M phase arrest and caspase-dependent apoptosis in lung cancer cells.
Локальные отклонения в проблеме распределения
последовательности $\{k\alpha\}$
Authors: Shutov Anton Vladimirovich
Published: March 2021

В работе рассматриваются локальные отклонения проблемы
распределения последовательности $\{k\alpha\}$,
т.е. остаточные члены асимптотических формул
для числа попаданий точек из рассматриваемой последовательности
в заданные интервалы. Приведена конструкция интервалов,
для которых локальные отклонения стремятся к бесконечности
медленнее любой наперед заданной функции. Более того, показано,
что существует несчетное множество таких интервалов.
Ранее аналогичные результаты были получены
только для иррациональностей
с ограниченными неполными частными разложения в цепную дробь.
Библиография: 26 названий.
Соотношение "коммутатор равен функции" в банаховых алгебрах
Authors: Aristov Oleg Yurevich
Published: March 2021

Соотношение $xy-yx=h(y)$, где $h$ - голоморфная функция,
возникает естественным образом в определениях некоторых квантовых
групп. Чтобы придать правой части этого равенства строгий смысл,
мы предполагаем, что $x$ и $y$ - элементы банаховой алгебры (или
алгебры Аренса-Майкла). Мы докажем, что универсальная алгебра,
порожденная таким коммутационным соотношением, может быть представлена
в явном виде как аналитическое расширение Оре. Анализ ее структуры
показывает, что множество голоморфных функций от $y$ вырождается,
и лишь в каждом нуле $h$ сохраняется некоторая локальная алгебра
степенных рядов. Более того, эта локальная алгебра зависит только
от порядка нуля. В качестве приложения мы докажем результат
о замкнутых подалгебрах голоморфно конечно порожденных алгебр.
Библиография: 25 названий.
Molecular Detection of Pathogens in Negative Blood Cultures in the Lao People’s Democratic Republic
Authors: Ter Soo Kai , Rattanavong Sayaphet , Roberts Tamalee , Sengduangphachanh Amphonesavanh , Sihalath Somsavanh , Panapruksachat Siribun , Vongsouvath Manivanh , Newton Paul N. , Simpson Andrew J. H. , Robinson Matthew T.
Published: March 2021

Bloodstream infections cause substantial morbidity and mortality. However, despite clinical suspicion of such infections, blood cultures are often negative. We investigated blood cultures that were negative after 5 days of incubation for the presence of bacterial pathogens using specific (Rickettsia spp. and Leptospira spp.) and a broad-range 16S rRNA PCR. From 190 samples, 53 (27.9%) were positive for bacterial DNA. There was also a high background incidence of dengue (90/112 patient serum positive, 80.4%). Twelve samples (6.3%) were positive for Rickettsia spp., including two Rickettsia typhi. The 16S rRNA PCR gave 41 positives; Escherichia coli and Klebsiella pneumoniae were identified in 11 and eight samples, respectively, and one Leptospira species was detected. Molecular investigation of negative blood cultures can identify potential pathogens that will otherwise be missed by routine culture. Patient management would have been influenced in all 53 patients for whom a bacterial organism was identified, and 2.3–6.1% of patients would likely have had an altered final outcome. These findings warrant further study, particularly to determine the cost–benefit for routine use, ways of implementation, and timing of PCR for organisms such as Rickettsia and Leptospira, which are important pathogens in rural Asia.
Gestión del clima institucional y desempeño del personal docente de la Institución Educativa N° 7044 San Martín de Porres, Chorrillos.
Authors: More Espinoza Renzo Augusto , Morey Guevara Marco Osias
Published: March 2021

La investigación persigue como objetivo: determinar la influencia de la gestión del Clima Institucional en el Desempeño del Personal Docente de la Institución Educativa n° 7044 San Martín de Porres, Chorrillos. La validez de la investigación se demuestra a través del juicio de expertos y la fiabilidad a través del alfa de Cronbach (0,922 y 0,839) para ambos instrumentos. Se concluye que tanto la variable “Gestión del Clima Institucional” como “Desempeño del Personal Docente” son percibidas sobre todo como buena, al igual que la mayoría de sus respectivas dimensiones y la correlación existente entre las mismas es positiva.
Obtención de curvas de intensidad-duración-frecuencia a partir de distribuciones de probabilidad en la cuenca media del río Chone.
Authors: Félix Mera John Enrique , Chávez Álava Jean Pierre , Muñoz Mendoza María Auxiliadora
Published: March 2021

En el presente artículo se realizaron las Curvas de Intensidad-Duración-Frecuencia (curva IDF) para la cuenca del río Chone a partir de los datos de intensidad máxima anual para duraciones de 5, 10, 15, 20, 30, 60, 120, 360, 1440 minutos; dichos datos se sometieron a funciones de distribuciones probabilísticas de mejor ajuste, determinado por el mínimo error estándar. Los resultados de esta investigación se compararon con la información proporcionada por INAMHI en sus estudios de lluvias intensas de 1999 y 2015.
Derivación de la constante de recesión de flujo base en tres microcuencas de la provincia de Manabí.
Authors: Rodríguez Bravo Miller Ernesto , Caicedo Toro Micheal David , Intriago Zambrano Pedro Elías , Giler-Ormaza Andy Miguel
Published: March 2021

Este artículo pretende analizar los flujos aportantes por parte de las aguas subterráneas en tres microcuencas de la provincia de Manabí localizadas en la cuenca alta de afluentes a las represas Poza Honda y La Esperanza, para lo cual se analizaran tres años de caudales con una resolución diaria, en dichos esteros que son de caudales intermitentes lo que denota un aporte de flujo base respecto a la proporcionalidad del caudal que en épocas de estiaje en las que la escorrentía directa es casi nula. La derivación de la constante de recesión se llevó a cabo mediante la utilización de un método numérico para la obtención de la constante de recesión de flujo base utilizado anteriormente por Bako y Hunt.
Indicadores de gestión financiera en pequeñas y medianas empresas en Iberoamérica: una revisión sistemática.
Authors: Párraga Franco Silvana Mariela , Pinargote Vázquez Nancy Fabiola , García Álava Carmen Marcela , Zamora Sornoza Juan Carlos
Published: March 2021

Las pequeñas y medianas empresas son vitales para la economía familiar y social. Las relaciones que generan las pequeñas y medianas empresas con la sociedad, específicamente con las familias, determinan la importancia de precisar los indicadores de gestión financiera que sustenten el proceso decisional en estas organizaciones. El propósito del estudio fue realizar un estudio descriptivo de revisión sistemática de los trabajos desarrollados en torno a los indicadores de gestión financiera en pequeñas y medianas empresas en el área geográfica iberoamericana. Se determinan los indicadores financieros de mayor empleo, y finalmente, se exponen algunas consideraciones sobre la significación del análisis contable como base para la toma de decisiones.
Understanding of Oral Oncology and its Change in Dynamics
Authors: Shrestha Aaniya
Published: March 2021

With the increase in smoking habits, oral cancer is turning into a threat among smokers. It is also due to a lack of awareness among people, oral cancer is increasing rapidly. The increased rate of illiterate people in Nepal has been a reason for a change in dynamics. Due to a lack of awareness, people are diagnosed late with cancer which leads to an increased mortality rate. So, awareness is a must for the reduction of oral cancer. In most cases, surgery is the best chance. Since people in Nepal are mostly from middle-class families, it highly impacts their life. The article primarily addresses the incidence of oral cancer in Nepal. It also emphasizes the risk factors and causes of oral cancer along with its diagnosis and surgery.
CONQUILIOMETRIA DE GASTRÓPODES NERITÍDEOS DA PRAIA DE ACCRA, BARBADOS, MAR DO CARIBE
Authors: Altomari Leslie , Alves Brunno , Santos Weverton , Santos Wagner , Barros Mara , Bezerra Andréa , Herrmann Marko , Chagas Rafael
Published: March 2021

The present study aims to characterize the conquiliometry of four species of neritid gastropod molluscs (Nerita tessellata, Nerita fulgurans, Nerita versicolor and Nerita peloronta), collected at Accra Beach, Barbados Island. For the characterization of the neritid conquiliometric pattern, the external measures (total length, width and height of the shell) and the measures of length and width of the shell opening were first measured, classifying the allometry of the morphometric relationships performed. The results presented here indicate that the neritids used in this study have morphometry significantly correlated, with allometry classified as "negative". Furthermore, it indicates the height and length measurements of the opening that determine the morphological distinction between N. fulgurans and the other species of neritids used.
Science Instructors' Views of Science and Nature of Science
Authors: Karakas Mehmet
Published: March 2021

This qualitative study examined how college science faculty who teach introductory level undergraduate science courses including the fields of chemistry, biology, physics, and earth science, understand and define science and nature of science (NOS). Participants were seventeen science instructors from five different institutions in the northeastern U.S. and all of them were interviewed. Consistent with previous research, the findings revealed that the participants in this study held sophisticated and complex conceptions of NOS. In some instances their views were in line with the views promoted by science philosophers, and in other instances their views were more mixed and naive. Findings show that engaging in scientific inquiry is not enough to ensure informed conceptions of NOS.
Online Dynamic Asynchronous Audit Strategy for Reflexivity in the Qualitative Paradigm
Authors: LaBanca Frank
Published: March 2021

The trustworthiness of a qualitative study can be increased by maintaining high credibility and objectivity. Of utmost importance to these factors is the reflexivity of the researcher. Standard journaling techniques are frequently used to maintain an audit trail and document tentative interpretations of a study. One of the major limitations to paper-based reflexivity is the lack of regular audit feedback. Online blogging tools can facilitate reflexivity and subsequent auditing with ease. Blogs are potentially cost-free, and only a rudimentary understanding of a web browser and word processing program are necessary for effective use. Moreover, blogs provide a simple, contiguous interface for an effective auditing process. An analysis of a reflexivity blog and subsequent audits is examined here. Findings indicate that the multiple perspectives of the auditors gave additional insights and that might not normally be considered by a researcher, providing a multi-arrayed perspective to interpretation of a study data set.
Working Together more than Alone: Students' Evolving Perceptions of Self and Community within a Four-Year Educational Administration Doctoral Cohort
Authors: Ford Lance , Vaughn Courtney
Published: March 2021

School administrators rarely have the opportunity to confer and share their challenges with colleagues. To address this problem in 2005 the Educational Administration Department (EAD) at Central University (a Midwestern PhD granting institution located in a thriving city of about 100,00 people) created a virtual/local doctoral cohort for 14 school leaders living and working in two states. Three years into the course of study we conducted a year long inquiry that asked, "How did students' self-perceptions evolve within a cohort context, and how did these changes advance or retard professional learning community (PLC) growth?" Our interviews had a phenomenological focus but we used symbolic interactionism to analyze them and dramaturgy to present our findings. Themes of faculty and student relationships, work and/or personal problems and dealing with technology indicated that despite some significant hurdles students' identity evolutions moved the group toward becoming a PLC, a collaborative culture of thinkers.
Ophthalmology for the Myopic Methodologist: A Review of Five Ways of Doing Qualitative Analysis
Authors: Root Carl
Published: March 2021

In Five Ways of Doing Qualitative Analysis, Frederick J. Wertz, Kathy Charmaz, Linda M. McMullen, Ruthellen Josselson, and Rosemarie Anderson provide students and researchers with both a broad knowledge base and specific examples of each of their preferred methods of analysis. The authors apply their respective expertise of phenomenological psychology, grounded theory, discourse analysis, narrative research, and intuitive inquiry to sixth author Emalinda McSpadden's narrative of responding to an unfortunate situation. The result is a comprehensive comparison of each method emphasizing unique strengths and weaknesses in each approach as well as the reflexivity required of researchers utilizing such analyses.
EFFICIENCY ANALYSIS OF HOSPITALS IN PUNJAB DISTRICTS: AN APPLICATION OF DEA BOOTSTRAP
Authors:   University of the Education, Lahore, Asghar Nabila
Published: March 2021

The main objective of this study is to analyze the efficiency of hospitals of districts of Punjab a province of Pakistan. The study uses output oriented DEA bootstrap technique formeasuring the efficiency of hospitals by utilizing four inputs and two outputs. The results ofthe study reveal that not a single district appears to be fully efficient when bias correctedefficiency technique is used. The overall efficiency which is measured in the form of mean efficiency have shown rising trend in 2011 and afterward little deterioration in 2013. Thestudy identifies the less efficient and highly efficient districts of hospitals of Punjab province of Pakistan. The inference from this study may be helpful for policy makers to formulate and implement policies which help the hospitals of districts of Punjab to perform better throughimproving their efficiency.
Формирование межкультурной компетенции в будущей профессиональной
деятельности специалистов морского транспорта в аспекте преподавания РКИ
Authors: Чуксина И.Г.
Published: March 2021

Раскрыта особая значимость межкультурной коммуникации в обучении иностранных курсантов морского вуза, поскольку знание специфики невербального коммуникативного поведения в будущей профессиональной деятельности специалистов морского транспорта и умение применять эти знания на практике играют чрезвычайно важную роль в процессе управле-ния интернациональным экипажем
Дистанционное образование: некоторые юридические проблемы опыта тотального применения
Authors: Прозоров А.В. , Герасимова А.В.
Published: March 2021

Представлен правовой анализ содержания понятий «дистанционное образование», «дистанционное обучение» «электронное обучение», «дистанционные образовательные технологии». Авторы исследуют юридические проблемы тотального применения дистанционного образования в России весной 2020 года. Федеральное законодательство Российской Федерации определяет дистанционное образование через два понятия: электронное обучение и дистанционные образовательные технологии. В национальном образовательном праве наблюдается заниженное положение дистанционного образования - это всего лишь специальные методы обучения. Авторы отстаивают идею законодательного закрепления за электронным обучением и дистанционными образовательными технологиями статуса самостоятельной формы получения образования
Технология подготовки руководителей к личностно-ориентированному
управлению персоналом
Authors: Андруник А.П.
Published: March 2021

Актуализируется проблема применения психолого-педагогических знаний руководителей в области современного менеджмента; значимость личностной ориентации (далее – ЛО) руко-водителя в деятельности по управлению персоналом в интересах инновационного развития со-временного предприятия, а также приводится авторская методика оценки уровня ЛО руководителя в системе управления
Memahami Penderitaan Dalam 1 Petrus 4:12-19 Dan Implikasinya Dengan Situasi Pandemi Covid 19
Authors: Marthen Enjelia , DOMINGGUS DICKY
Published: March 2021

Abstrak

Penderitaan merupakan sesuatu yang menjadi bagian dalam kehidupan manusia. Artinya semua orang pasti mengalami penderitaan. Penderitaan yang dimaksud bisa dalam berbagai macam seperti sakit penyakit, kesusahan ekonomi, diskriminasi, tekanan psikologi dan lainnya. Petrus menuliskan penderitaan di dalam teks 1 Petrus 4:12-19. Di dalam teks ini, Petrus sedang mendorong jemaat agar bertahan dalam penderitaan yang dialami. Penelitian ini merupakan penelitian kualitatif dengan pendekatan historikal gramatikal. Dalam penelitian ini, dilakukan penelitian teks 1 Petrus 4:12-19 untuk menemukan makna mula-mula penderitaan yang dimaksudkan oleh Petrus. Berdasarkan penelitian yang dilakukan dapat disimpulkan bahwa penderitaan yang dimaksudkan oleh Petrus merupakan penderitaan karena iman kepada Kristus. Dengan demikian, penting bagi orang percaya pada masa kini untuk dapat memahami penderitaan dengan benar sebagai sesuatu yang wajar dihadapi manusia dan berada dalam kedaulatan Allah.
USO HÍDRICO EN LA PRODUCCIÓN AGRÍCOLA DE LA PARROQUIA LODANA DEL CANTÓN SANTA ANA
Authors: Vélez Morales Lisbeth Melina , Fuentes Venegas Miguel Ángel , Moreira Álava María Fernanda , Lucio Villacreses Luis Fernando
Published: March 2021

El presente artículo ha sido relacionado con los objetivos de desarrollo sostenible 6 “Agua limpia y saneamiento. Garantizar la disponibilidad de agua y su gestión sostenible y el saneamiento para todos” con la finalidad de conocer el uso hídrico que se realiza en la producción agrícola de la parroquia Lodana, para el efecto se utilizaron el método deductivo, exploratorio y cuantitativo que nos permitió consolidar una encuesta aplicada a cincuenta agricultores de la zona. Entre los resultados más importantes encontramos que el 80.4% de la muestra encuestada cuenta con la disponibilidad de agua para la producción agrícola sin problema alguno, de los cuales el sistema de riego más utilizado es la aplicación de surcos y para llevar el agua a la finca se utilizan bombas de caudal, por otro lado, el 41% de los agricultores encuestados están dispuestos a la utilización de aguas grises en el riego de sus cultivos. También se tomó en cuenta el Objetivo de Desarrollo sostenible 8, meta 8 que indica “se lograrían niveles más altos de productividad para la economía de la población ya que la rentabilidad es inestable, mediante la capacitación de nuevas tecnologías de aprendizaje a los agricultores, de adaptación y prevención se verá mejorado el cultivo”, donde se determinó que la rentabilidad de la actividad agrícola es variable,  ya que el 73% requiere realizar otras actividades laborales dentro y fuera de la parroquia para generar ingresos, debido a los costos de producción altos comparados con el costo de venta en el sector agrícola, lo mismo que impide a los agricultores desarrollar nuevas tecnologías de uso sostenible del agua.