bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation of neurological clinical and brain computed tomography findings of stroke patients – a multicenter study from a low-income setting
Authors: Vincent Mboizi , Sereke Senai Goitom , Nassanga Rita , Robert Mukisa , Ameda Faith
Published: November 2022

Background: In developing countries like Uganda, the burden of stroke is growing and causing significant morbidity and disability with high mortality rates. Neuroimaging is required to differentiate ischemic stroke from an intracerebral hemorrhage, as well as to diagnose entities other than stroke. Therefore, understanding the clinico-demographic features and brain Computed Tomography (CT) findings of stroke as well as their correlation is of utmost value in stroke management. Hence, this study sought to determine the clinical and brain CT scan findings of stroke patients attending selected centers in Kampala. Mention ASPECTS briefly
Methods: This was a cross-sectional study of clinically suspected stroke patients at three selected hospitals in Kampala, Uganda. All brain CT scans of patients with suspected stroke were evaluated and The Alberta stroke programme early CT score (ASPECTS) a 10-point quantitative topographic CT scan score used for middle cerebral artery (MCA) stroke patients. Data on the clinical-demographic and cranial CT findings were collected, and entered into REDCap software. Univariate analysis was used to describe the clinico-demographic and cranial CT features of stroke and summarized them as percentages. Further analysis was done at bivariate and multivariate levels to determine the adjusted odds ratios as a measure of association with a 95% confidence interval.
Results: Of the 270 study participants,141(52.2%) were male. 162(60%) had CT findings of stroke, and 90(33.3%) had normal cranial CT findings. While 18(6.7%) had other CT findings like a tumor, dural hemorrhage, epidermoid cyst, and others. The ischemic stroke, hemorrhagic stroke, and subarachnoid hemorrhage accounted for 124(45.9%), 34(12.6%), and 4(1.5%) respectively. Limb weakness (55.2%), headache (41.1%), and loss of consciousness (39.3%) were associated with stroke findings on CT. Among the acute ischemic strokes, 30(73.2%) had a worse (0-7) ASPECT score. Those aged ≥65 years were associated with a worse ASPECTS [AOR: 22.01, (95%CI:1.58-306.09) p-value =0.021].
Conclusion: Currently, non-contrasted brain CT is the first line imaging modality for diagnosis, differentiation of the stroke types, patient management, treatment, and timely referral to a stroke center. The clinical diagnosis of stroke is inadequate to exclude other stroke mimics. Hypertension and advanced age are the most prevailing risk factors attributed to both ischemic and hemorrhagic stroke and patients over 65 years were associated with a worse ASPECT score.
Machine learning-guided discovery of ionic polymer electrolytes for lithium metal batteries
Authors: Li Kai , Wang Jifeng , Song Yuanyuan , Wang Ying
Published: November 2022

Development of ionic polymer electrolytes (IPEs) without flammable organics is a critical strategy to enable safe and high-energy lithium metal batteries (LMBs). As critical components in IPEs, ionic liquids (ILs) with high ionic conductivity and wide electrochemical window are promising candidates to enable LMBs. Here, we describe a fast and robust machine learning workflow embedded with quantum chemistry calculation and graph convolutional neural network to discover promising ILs for IPEs. By selecting subsets of the recommended ILs, combining with a rigid-rod polyelectrolyte and a predetermined lithium salt, we develop a class of large area and mechanically strong IPE membranes with thickness ~ 50 μm. The symmetric cells exhibit stable cycling performance at 1 mA cm-1 (0.5 mAh cm-2) up to 800 h at room temperature (RT) and excellent reversibility at 6 mA cm-2 (3 mAh cm-2) at 80 °C. With LiFePO4 loading ~ 10.3 mg cm-2, the full cells deliver outstanding capacity retention for > 350 cycles (> 96% with 0.5 C at RT; > 80% with 2 C at 50 °C), fast charge/discharge capability (146 mAh g-1 with 5 C at 80 °C) and ultrahigh coulombic efficiency (> 99.92%). This performance is rarely reported by any single-layer polymer electrolytes without any organic plasticizers/oligomers for LMBs.
Quality of life in intermittent exotropia for Korean children and their parents
Authors: Oh Jin Seon , Jung Jae Ho , Shin Hyun Jin
Published: November 2022

Background: Patients with strabismus are more likely to have mental health problems, including high rates of depressive symptoms and social phobia. Intermittent exotropia (IXT) typically occurs in early childhood and is more common in Asian populations. We aim to assess the health-related quality of life (HRQOL) concerns in children with intermittent exotropia (IXT) using the Intermittent Exotropia Questionaire (IXTQ), and their associations with the clinical severity of IXT and the parents’ HRQOL concerns.
Methods:One hundred twenty-two children with IXT (aged 5–17 years) and one parent for each child completed the child and parent IXTQ, respectively. The final IXTQ score is calculated using the mean score for all items, and ranges from 0 (worst HRQOL) to 100 (best HRQOL). The correlations of child IXTQ scores with their deviation angle and stereoacuity were measured, as were those with their parent’s IXTQ scores.
Results: The greatest HRQOL concern for each child with IXT and their parent was “Worry about eyes.” Lower child IXTQ scores were associated with a larger deviation angle. “Shutting one eye when it is sunny” and “Waiting for their eyes to clear up” were more common in children with a larger deviation angle. The parent IXTQ scores were lower than the child ones and showed a positive correlation with child IXTQ scores. Lower parent IXTQ scores were associated with poor distance stereoacuity.
Conclusion: The HRQOL of IXT children was closely related to that of their parents. A larger deviation angle and worse distance stereoacuity function may predict more-negative impacts on children and their parents, respectively.
Molecular dynamics study of unexpected hydrate formation from supersaturated methane solution at low pressure
Authors: Belosludov Vladimir R. , Gets Kirill V. , Zhdanov Ravil K. , Bozhko Yulia Yu. , Belosludov Rodion V. , Chen Li-Jen , Kawazoe Yoshiyuki
Published: November 2022

Using molecular dynamics the evolution of a metastable solution for "methane + water" was studied for various methane concentrations at T = 270 K and P = 1 bar. We have found the intriguing behavior of the system: the formation of hydrate-like structures is observed in the concentration range. This formation was studied on different time scale levels. We have shown that this process is a collective process of H-bond network reorganization in solution at the initial stage (0–1 ns) until the first fluctuating cavities appear. This is associated with a preceding increase of tetrahedrality the water molecules. The molecules with a high degree of tetrahedrality are distributed uniformly throughout the volume. The formation of small and large fluctuation cavities present in the structure I (sI) appears before steady hydrate growth begins. Later, the constantly present hydrate cavities become the foundation for a few independent hydrate nucleation centers. This new mechanism of hydrogen bond network reorganization depends on the entropy of the cavity arrangement of the guest molecules in the hydrate lattice and leads to the hydrate growth.
Use of inhaled nitric oxide prognosticates poor survival in severe ARDS with venovenous ECMO: a retrospective analysis
Authors: Muenster Stefan , Nadal Jennifer , Schewe Jens-Christian , Ehrentraut Heidi , Kreyer Stefan F. X. , Putensen Christian , Ehrentraut Stefan F.
Published: November 2022

Background
Inhaled nitric oxide (iNO) has not been sufficiently evaluated in adult patients with severe acute respiratory distress syndrome (ARDS) under venovenous extracorporeal membrane oxygenation (VV ECMO) support.
Objectives
This study aims to assess survival in patients with severe ARDS under VV ECMO with iNO.
Methods
Of the 657 patients under ECMO, 292 under VV ECMO were evaluated. Outcomes in the iNO group (n = 55) were compared with those of the propensity-matched (based on age, sex, height, and sequential organ failure assessment score at admission) control cohort (55 patients under VV ECMO without iNO). Median survival was analyzed using the Kaplan–Meier method, whereas the hazard ratio for in-hospital mortality with iNO use was analyzed using the proportional hazards model.
Results
Weaning failure from VV ECMO was higher in the iNO group (69.7% vs. 47.3%, p = 0.0033). Thirty percent of patients responded sufficiently to iNO, showing a lower pulmonary arterial pressure. Survival was lower in the iNO group compared with the control cohort (22 vs. 109 days, p = 0.0222). The length of stay in the intensive care unit (ICU) (23 vs. 33 days, p = 0.0186) and total hospital stay (27 vs. 35 days, p = 0.0085) were shorter with iNO use. Survival was lower and the risk of mortality (hazard ratio, 1.8; 95% CI 1.1–3.0, p = 0.027) was higher in patients with iNO administration.
Conclusions
Inhaled NO in patients under VV ECMO is a strong predictor of shorter median time of survival and in-house mortality.
Hereditary Diffuse Gastric Cancer in a Japanese Family with CDH1 Mutation: Three Individuals Undergoing Total Gastrectomy Following Presymptomatic Genomic Diagnosis
Authors: Muranaka Futoshi , Kise Emiko , Tokumaru Shigeo , Kitazawa Masato , Miyagawa Yusuke , Suga Tomoaki , Uehara Takeshi , Iwaya Mai , Kobayashi Shota , Sato Midori , Gomi Daisuke , Yamada Hidetaka , Sugimura Haruhiko , Kosho Tomoki , Soejima Yuji , Koizumi Tomonobu
Published: November 2022

Background;
Germline pathogenic variants in the E-cadherin gene CDH1 cause hereditary diffuse gastric cancer (HDGC), which is an autosomal dominant cancer syndrome, accounting for 1% of all gastric cancers. HDGC harboring a CDH 1 variant is extremely rare in Japan.
Method;
Here, we describe four cases of HDGC in a single Japanese family.
Results;
The proband exhibited advanced and metastatic gastric cancer, and was found to have a previously reported heterozygous frameshift variant in CDH1 (NM_004360.3:c.1009_1010del:p.Ser337Phefs*12). Five at-risk relatives underwent presymptomatic molecular testing after careful genetic counseling, and three were molecularly diagnosed as positive for the variant. Esophagogastroduodenoscopy was performed in three relatives, which revealed abnormal small pale mucosal patches, small ulcerative lesion, and no abnormal findings, respectively. Random and targeted biopsies were compatible with the pathological diagnosis of HDGC. They underwent total gastrectomy and Roux-en-Y reconstruction with D2 lymph node dissection.
Conclusion;
In the management of HDGC, multidisciplinary and family-oriented approaches are critical, including genetic analysis of CDH1 variants in the proband, presymptomatic diagnosis of at-risk relatives through careful genetic counseling, and random biopsy-based surgery or prophylactic total gastrectomy.
Early Safety and Efficiency Outcomes of a Novel Standardized Interdisciplinary Procedure of Combined Laparoscopic Resection Rectopexy with Laparoscopic Sacrocolpopexy to Treat Obstructive Defecation Syndrome in Women with Pelvic Organ Prolapse
Authors: Ludwig Sebastian , Madukkakuzhy Joshy , Hernandez Alberto Vega , Otten Jakob , Ulrici Christoph , Karapanos Leonidas , Rudroff Claudia
Published: November 2022

Purpose
Obstructive defecation syndrome (ODS) defines a disturbed defecation process frequently associated with pelvic organ prolapse (POP) in women. It substantially compromises quality of life. Conservative treatment options are limited. Surgical interventions are characterized by a variety of individual approaches. This study standardized laparoscopic resection rectopexy (L-RRP) combined with laparoscopic sacrocolpopexy (L-SCP) in an interdisciplinary setting. Additionally, offering both synthetic mesh (SM) and biological mesh (BM) material for L-SCP is a novel treatment alternative, particularly for premenopausal women.
Methods
Women with ODS combined with POP underwent surgery using an interdisciplinary approach. The primary endpoint was postoperative morbidity and mortality measured by the Clavien-Dindo classification (CDC). Further endpoints were improvement in bowel evacuation, POP, and urinary incontinence at a median follow-up period of > 12 months.
Results
Of a total of 44 patients, 36 patients were treated with L-RRP combined with L-SCP (28 patients with SM, 8 patients with BM). CDC grades and the frequency of postoperative complications were low. Clinical outcomes for ODS, bowel dysfunction, and fecal control improved significantly. Anatomical outcome for POP was significantly better with 28 (78%) patients having POP-Q stage 0 after surgery. 17 patients (47%) had urinary incontinence before surgery, which was restored in 14 patients (82%). No de-novo urinary incontinence appeared.
Conclusion
The interdisciplinary surgical approach with L-RRP and L-SCP is safe, feasible, and effective in treating women with ODS and POP. The use of a biomesh was established as an effective alternative to the SM and offers an additional and new uterine-preserving option.
High molar activity [18F]Tetrafluoroborate synthesis for Sodium Iodide Symporter imaging by PET.
Authors: Soloviev Dmitry , Dzien Piotr , Mackintosh Agata , Malviya Gaurav , Brown Gavin , Lewis David
Published: November 2022

Background. Sodium iodide symporter (NIS) imaging by positron emission tomography is gaining traction in nuclear medicine, with a number of human studies recently published using fluorine-18 labelled tetrafluoroborate ([18F]TFB). Clinical success of any radiotracer relies heavily on its accessibility, which in turn depends on the availability of robust radiolabelling procedures providing a radiotracer in large quantities and of high radiopharmaceutical quality.
Results. Here we publish improved radiolabelling of and quality control procedures for [18F]TFB with high molar activity. The use of ammonium hydroxide for [18F]fluoride elution, of commercially available boron trifluoride-solvent complex as precursor and removal of unreacted [18F]fluoride on Florisil solid-phase extraction cartridges resulted in the reliable production of [18F]TFB on SYNTHRA and FX-FN automated synthesizers with radiochemical yields in excess of 30%, radiochemical purity in excess of 98% and molar activities in the range of 35 -217 GBq/μmol at the end of synthesis.
Conclusions. A novel automated radiosynthesis procedure for [18F]tetrafluoroborate has been developed that provides radiotracer with high molar activity. PET scanning of a mouse lung tumour model carrying an NIS reporter gene rendered images of high quality and improved sensitivity.
Vision-driven Deep Reinforcement Learning for Electronic Components Robotic Insertion Tasks
Authors: Bartyzel Grzegorz Marcin , Półchłopek Wojciech , Rzepka Dominik
Published: November 2022

One of the challenges of robotics in the modern manufacturing industry is assembly task. The manufacturing industry requires various insertion tasks, from peg-in-hole tasks to electronic parts assembly. Nowadays, robotic solutions for this problem often use the conventional methods. In those methods, the industrial robot is controlled by the hybrid force-position control and performs preprogrammed trajectories, such as a spiral path. However, electronic parts require more sophisticated techniques due to their complex geometry and susceptibility to damage. We propose a vision-driven method based on reinforcement learning (RL) for assembling electronic parts. In our approach, the input image for the RL agent is acquired from two cameras mounted to the robot's end-effector. In this work, we also analyze the influence of the observation modalities on the RL's agent performance metrics, such as insertion success rate and average assembly time. Results show that visual information acquired from a double-camera vision system significantly improves the RL method's robustness on the position disturbance in insertion tasks. The proposed method in this work outperforms conventional methods, such as random search, spiral search, and straight-down insertion in terms of success rate and robustness for the robot's initial position disturbances. Moreover, our approach is more robust for disturbance than a method that uses an external camera or a single camera mounted to the robot's end-effector for image acquisition.
Expression and prognostic value of LRFN family genes in prostate cancer by integrated bioinformatics analysis
Authors: Pan Haojie , Liu Suwei , Wu Mingzhe , Zhou Anan , Xiao Xi , Tian Junqiang
Published: November 2022

To analysis the expression of Leucine‑rich repeat fibronectin type 3 domain containing family genes(LRFNs) in prostate cancer (PCa) and its relationship with clinical features and prognosis. The PCa gene expression profiles were collected from UCSC Xena, and corresponding clinical information was extracted from the cBioPortal website. R and Cytoscape software and online tools such as HPA, cBioPortal, LinkedOmics, String, Metascape, and TIMER2 were used for bioinformatics analysis. LRFN1/2 were upregulated in various tumor tissues, including PCa, while the expression of LRFN3/4/5 were downregulated. LRFN1/2/4 were associated with disease-free survival (DFS) in PCa. LRFN4 was also associated with Gleason score and TNM staging. The protein-protein interaction (PPI) network analysis indicates that the LRFN protein family binds to the Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation protein or 14-3-3 protein(YWHA). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that the LRFNs and its 250 co-expressed genes are involved in protein binding and transmembrane transport, cell cycle regulation, and the PI3K-Akt pathway, etc. Besides, upregulation of the LRFN5 was correlated with the increased infiltration of immune cells such as B cells, CD4+ T cells, CD8+ T cells, macrophages, neutrophils, dendritic cells, and the increased expression levels of various immune molecules. LRFNs have an essential role in the development and progression of PCa. LRFN1/2 expression is upregulated in PCa and LRFN3/4/5 expression is downregulated; LRFN1/2/4 may serve as potential prognostic biomarkers in PCa. LRFN3 and LRFN5 may be involved in regulating alterations of the immune microenvironment in PCa tumors.
Modelling of cooling effects in tool grinding using numerical simulations of the wetting behaviour of grinding wheels
Authors: Wichmann Marcel , Eden Michael , Zvegincev Dennis , Wiesener Frederik , Bergmann Benjamin , Schmidt Alfred
Published: November 2022

In manufacturing of cylindrical cemented carbide tools, helical flute grinding is an important process step. Process planning and the use of cooling lubricants are defining factors for process performance. Therefore, finding optimal parameters and cooling conditions is essential because they characterize the properties of the boundary zone, e.g. residual stresses. In this paper, grinding oil droplet experiments are compared with simulation results to describe the wetting behavior of different grinding wheel based on their specifications (grain size, bonding structure, and wetting status). More specifically, finite element simulations of the thin-film equation are used to identify corresponding slip parameters that will be used in more complex 3D fluid-dynamic simulations via the Joseph-Beavers condition. The results show that both the bonding and, to a lesser degree, the grain size have an influence on the wetting behavior. This presents an intermediate step in getting a better understanding of the cooling properties of lubricants in grinding processes, where the wetting effectiveness plays an important role for the heat transport.
Dermatobacter hominis gen. nov., sp. nov., a new member of the family Iamiaceae, isolated from keratin epidermis
Authors: Jo HyungWoo , Baek Chaeyun , Heo Young Mok , Kim Hye-Been , Kang Seunghyun , Mun Seyoung , Oh Yunseok , Han Kyudong , Riesco Raúl , Trujillo Martha E. , Lee Dong-Geol
Published: November 2022

A non-motile, novel actinobacterial strain, designated Kera-3T, was isolated on 1/10 diluted R2A agar from human keratinocytes. Strain Kera-3T was Gram-stain-positive, aerobic and rod-shaped. The whole-cell hydrolysis of amino acids contained meso-DAP, alanine, and glutamic acids. The main menaquinone was MK-9 (H8). The major fatty acids were C16:0 and C18:1 ω9c. The major phospholipids were diphosphatidylglycerol and aminophospholipid, along with an unidentified phosphoglycolipid and an unidentified aminophosphoglycolipid. The G + C content of the genomic DNA was 70.5 % based on the complete genome sequence. Phylogenetic analyses of the 16S rRNA gene sequence and core-gene based on amino acid sequence clearly showed that strain Kera-3T formed a new lineage in the family Iamiaceae, being the closest neighbour Rhabdothermincola sediminis SYSU G02662T with a 91.19% 16S rRNA gene sequence identity. Phylogenetic data was supported with a comparative genomic study of the predicted general metabolism and carbohydrate active enzymes. Based on physiological and biochemical characteristics data analysis. Strain Kera-3T can be distinguished from known genera in the family Iamiaceae and represents a novel genus and novel species. Therefore, the name Dermatobacter hominis gen. nov., sp. nov. is proposed with the type strain being Kera-3T (= KACC 22415T = LMG 32493T).
Tumour cell-induced senescence-like state of macrophages plays a pivotal role in tumour stable growth after tumour cell emergence in immunocompetent condition
Authors: Wada Haruka , Otsuka Ryo , Germeraad Wilfred , Murata Tomoki , Kondo Toru , Seino Ken-ichiro
Published: November 2022

Background: The cancer stem cell theory proposes that tumour formation in vivo is driven only by specific tumour-initiating cells having stemness; however, clinical trials conducted to test drugs that target tumour stemness have provided unsatisfactory results thus far. Recent studies showed clear involvement of immunity in tumours; however, the requirements of tumour-initiation followed by stable growth in immunocompetent individuals remain largely unknown.
Methods: To clarify this, we used two similarly induced glioblastoma lines, 8B and 9G. They were both established by overexpression of an oncogenic H-RasL61 in p53-deficient neural stem cells. In immunocompromised animals in an orthotopic transplantation model using 1000 cells, both show tumour-forming potential. On the other hand, although in immunocompetent animals, 8B shows similar tumour-forming potential but that of 9G’s are very poor. This suggests that 8B cells are tumour-initiating cells in immunocompetent animals. Therefore, we hypothesised that the differences in the interaction properties of 8B and 9G with immune cells could be used to identify the factors responsible for its tumour forming potential in immunocompetent animals and performed analysis.
Results: Different from 9G, 8B cells induced senescence-like state of macrophages around tumours. We investigated the senescence-inducing factor of macrophages by 8B cells and found that it was IL-6. Such senescence-like macrophages produced Arginase-1, an immunosuppressive molecule known to contribute to T cell hyporesponsiveness. The senescence-like Mφs highly expressed CD38, a nicotinamide adenine dinucleotide (NAD) glycohydrolase associated with NAD shortage in senescent cells. The addition of nicotinamide mononucleotide (NMN), a NAD precursor, in vitro inhibited to induction of macrophage senescence-like phenotype and inhibited Arginase-1 expression resulting in retaining T cell function. Moreover, exogenous in vivo administration of NMN after tumour inoculation inhibited tumour-initiation followed by stable growth in the immunocompetent mouse tumour model.
Conclusions: We identified one of the requirements for tumour-initiating cells in immunocompetent animals. In addition, we have shown that tumour growth can be inhibited by externally administered NMN against macrophage senescence-like state that occurs in the very early stages of tumour-initiating cell development. This therapy targeting the immunosuppressive environment formed by macrophage senescence-like state is expected to be a novel promising cancer therapeutic strategy.
Meta-transcriptional Detection of Rickettsia canadensis from Ixodes persulcatus in China
Authors: Shi Mingjie , Qin Tong , Liu Zhitong , Feng Hao , Sun Yi , Zhang Meina
Published: November 2022

Genus Rickettsia associated to blood-feeding arthropods are usually pathogenic when transmitted to vertebrates. These species include the agents of acute human disease such as typhus and Rocky Mountain spotted fever. However, many other Rickettsia have been uncovered with uncertain pathogenic to vertebrates in recent surveys. It is therefore perhaps more appropriate to consider these Rickettsiaas endosymbionts that are transmitted vertically in invertebrates, and secondarily as pathogens of vertebrates. Rickettsia canadensis, an ancestor species in genus Rickettsia, had been well characterized for its peculiar genome size and genes’ contents bridging the pathogenic Rickettsiaand non-pathogenic ones. However, there is few research on the ancient rickettsia species in China which may seriously influence our pursue for the evolutionary nature of Rickettsia in China.
In the present study, R. canadensis was detected from Ixodes persulcatusticks from forest areas of both Heilongjiang province and Inner Mongolia Autonomous Region in northern China. The molecular evidences from both 16S rRNA gene and 3 arrays of gene transcripts strongly indicated the natural infection of R. canadensis occurs in Ixodid ticks in China. The gene transcripts including rpoB-rpoC-rpoC/160KDa-leucyl aminopeptidase-hypothetical protein-leucyl aminopeptidase-aspartate tRNA ligase, RlmE-Omp 1-Peptidase M50-nusB, dnaK-dnaJ-ChaBfamily protein-BamD-RecN-Carboxypeptidase M32 revealed from I. persulcatus suggested the intensive interactions between R. canadensis and. host ticks, which would provide scientific clues to highlight the possible evolutionary trajectory of Rickettsia species in China.
Can China’s Hu Huanyong Line be broken to achieve common prosperity in the new development stage?
Authors: zhao dandan , wu fuxiang , huang jiayi
Published: November 2022

We analyse the causes of unbalanced development on both sides of the Hu Line and seek to narrow the gap in regional economic development levels. Achieving common prosperity is the fundamental principle, ultimate goal and basic requirement of socialism with Chinese characteristics. In this study, a total of 48 cities on both sides of the Hu Line are selected as samples, and an assessment system covering 18 indicators based on 8 aspects is constructed. A regression discontinuity method is adopted to test the differences in regional development on both sides of the Hu Line. The results show that the breakpoint effect on both sides of the Hu Huanyong Line is very obvious and that there is a significant imbalance in development, which is mainly reflected in eight aspects: population, economic output, finance, public finance, educational resources, employment, medical facilities, and urban development and construction. The results suggest that a large amount of work should be performed to increase fiscal support, strengthen public facility construction, improve medical and health levels, enhance investment in human capital and education, and accelerate the urbanization processes on the left side of the Hu Huanyong Line.
Retrospective study of mineral pollution in the Tshamilemba district of the City of Lubumbashi, DR Congo
Authors: Ramazani Ben Sadiki , Mpanga Fabien Ilunga , Lutandula⃰ Michel Shengo
Published: November 2022

Since 2002, Thamilemba quarter, located in the City of Lubumbashi (DRC), is a home to mining activities for the hydrometallurgical extraction of copper and cobalt. Consequently, great amounts of mineral wastes were improperly stored resulting in toxic metals liberation and contamination of the surrounding soil and the near to surface waters. This research determined major physicochemical parameters and measured the trace metal elements (TMEs) concentrations in samples of soil, water and plants. Based on data given by the samples analysis, it established the spatial distributions of metals in both the upper and deep soil (20 cm) through the data mathematical processing with the Matlab 7.1 software. The samples analysis results were compared to quality standards to ascertain the population's fear about the environment pollution is justified or not. An average pH value of 7.69 was measured in the soil and a value of 9.1 in whitish substances found at some spots. The soil samples presented TMEs concentrations above standards (0.5 mg/kg) or phytotoxic levels in the upper soil layers (Co, Cu, Fe and Zn) and in the deep layers (Co, Cu, Fe, Zn and Pb). Water samples contained TMEs to concentrations (Cu, Co, Mn, Zn and Pb) greater than drinking water quality standards set by the World Health Organization (WHO). The plant samples contained TMEs to high levels: Saccharum officinarum (Co, Cd, Ni, Mg and Pb) and in Musa acuminate (Co, Cd, Ni, Mn, Zn and Pb). These findings show that toxic metals endanger the wildlife and human health and confirm the population fears about the environment deterioration.
Longitudinal analysis of influenza vaccination implicates regulation of RIG-I signaling by DNA methylation
Authors: Fu Hongxiang , Pickering Harry , Rubbi Liudmilla , Ross Ted M. , Reed Elaine F. , Pellegrini Matteo
Published: November 2022

BackgroundInfluenza virus infection alters the promoter DNA methylation of key immune response-related genes, including type-1 interferons and proinflammatory cytokines. However, less is known about the effect of the influenza vaccine on the epigenome. We utilized a targeted DNA methylation approach to study the longitudinal effects (day 0 pre-vaccination and day 28 post-vaccination) on influenza vaccination responses in peripheral blood mononuclear cells.ResultsWe found that baseline, pre-vaccination methylation profiles are associated with pre-existing, protective serological immunity. Additionally, we identified 481 sites that were differentially methylated between baseline and day 28 post-vaccination. These were enriched for genes involved in the regulation of the RIG-I signaling pathway, an important regulator of viral responses.ConclusionsOur results suggest that DNA methylation changes to components of the RIG-I pathway are associated with vaccine effectiveness. Therefore, immunization strategies that target this pathway may improve serological responses to influenza vaccination.
Detail design (DD), front end (FE), back end (BE) design of non-tactical deployable 20 GWh (17.20841 kilo ton TNT) plane wave lens configuration fusion device
Authors: Rafique Muhammad Musaddique Ali
Published: November 2022

A simple plane wave lens, using an inert central plastic wave shaper, has been designed. An experiment was done with a 4 in diam, zeroth order design. An iterative technique that uses measured time deviations to connect the next wave shape was developed. Two identical versions of the first iterated shape were fired. Arrival time deviations in these first iterates fell within 50 ns bonds. With greater care and further iterations, lenses bound by 10 ns deviations seem possible. An advanced and novel integration method is applied. It is shown that this technique bears significant advantage over prior methods and is meritorious.
Continuous noninvasive monitoring of the hemoglobin during cardiac surgery and comparative analysis with existing technique
Authors: Khaleelullah Mohamed Mathar Sahib Ibrahim , Kawashima Shingo , Morita Koji , Mimuro Soichiro , Kurita Tadayoshi , Nakajima Yoshiki
Published: November 2022

Hemoglobin (Hb) concentration monitoring is the most required analysis during surgery and critical care treatment to make proper decision regarding blood transfusion. Blood gas analysis is required invasive intermittent blood sampling. Various non-invasive Hb monitoring techniques are under research for better real time patients’ management. Masimo rainbow® Pulse CO-Oximeter® is to monitor continuous and noninvasive hemoglobin (SpHb) whereas blood samples give intermittent results. Recently, disposable SpHb sensor has been updated. We evaluate the SpHb sensor compared with total Hemoglobin(tHb) in patients undergoing cardiac surgery using cardiopulmonary bypass (CPB).
A total of 272 SpHb and tHb paired data samples from 60 patients. To analyze the tHb, the patients’ blood samples were drawn intermittently by the radial arterial line and blood gas analyzer ABL 90 (Radiometer corp., Denmark) as per anesthesiologist decision. SpHb sensors (RD rainbow SET-2 Adt sensor, Masimo Corp., USA) were attached to the patients’ ring finger connected to Root® with Radical-7®. Reliability and trending ability between the SpHb and tHb were analyzed by the regression analysis, Bland-Altman analysis, four quadrant plots and polar plot. Limits of agreement between SpHb and tHb is calculated to be -2.01 to 2.2 g/dL with a bias of 0.13 g/dL. The correlation coefficient (r) of SpHb and tHb were 0.8036. Concordance ratio of four quadrant and polar plots were 93% and 91%, respectively.
Both Absolute and trend accuracy of SpHb with the latest version are clinically acceptable in patients undergo cardiac surgery using CPB.
A Hybrid Feature Method for Early Fake News Detection via Event Categorizer
Authors: Zhao Buze , Deng Hai , Hao Jie
Published: November 2022

Fake news detection with hybrid features has attracted a great dealof attention due to its great potential in preventing the spread offake information in social media, and it has become an importanttask to be addressed due to many negative effects such as reader misleading, economic recession and political volatility. In this paper, wepropose an event categorizer-based neural network (HECNN) framework for hybrid feature fake news detection, which combines a hybridfeature extractor and an event categorizer to extract transferable features of different events for fake news detection. Moreover, we extracta series of features from text, visual text, visuals, and user profilesfor fake news detection. The experimental results show that the proposed HECNN model improves the accuracy and F1 score comparedto the baseline as well as other advanced deep learning methods.
Awareness about post-mortem eye donation among students of the Syrian Private University
Authors: Alameddin Ammar , Dugha Ghaith , Salman Afraa
Published: November 2022

Background
Eye donation (corneal donation) is the process of screening a corneal donor, recovering the corneal tissue, and preparing it for transplant. People who benefit from corneal donation are those who suffer from corneal blindness. This study aims at assessing the awareness of eye donation among students of the Syrian Private University of various faculties and their readiness for post-mortem eye donation
Methods
A student-based cross-sectional study was conducted in faculties of the Syrian Private University. A total of 538 students between the ages of 18 and 36 were selected. After obtaining informed written consent, knowledge regarding eye donation was assessed through a pre-designed closed questionnaire. The questionnaire was drafted to understand the sociodemographic factors that influence the desire to donate and the awareness of eye donation in this category of community members.
Results
The mean age of the participants was 21.48 ± 2.45 years. 61% of the participants were females while 39% were males. 75% of the participants heard of eye donation. 65% were aware of post-mortem eye donation. 39% of the participants knew that there is a certain age for eye donation, and 85% believed that corneal diseases can lead to blindness. 303 students knew that Keratoplasty is performed in Syria while 235 students didn’t know. 36% of the participants wanted to donate eyes after death, while 64% refused. The branch of the study was an important determining factor in terms of knowing eye donation, as the largest percentage of students who wanted to donate eyes after death were from the faculty of medicine (P = 0.0144).
Conclusion
Despite the relatively good knowledge and awareness ratios among students, they were among the students of the medical branches, which indicates the lack of knowledge and awareness about the donation of eyes among the students of the rest of the faculties, which calls for a rethinking of ways to raise knowledge and awareness among all students in different branches of study.
Recipient independent high accuracy FMT prediction and optimization in mice and humans
Authors: Shtossel Oshrit , Turjeman Sondra , Riumin Alona , Goldberg Michael R. , Elizur Arnon , Mor Hadar , Koren Omry , Louzoun Yoram
Published: November 2022

Background Some microbiome composition can be associated with negative outcomes, including among others, obesity, disease and the failure to respond to treatment. Microbiota manipulation or supplementation have been argued to restore the microbiome associated with a healthy condition. Fecal Microbiota Transplantation (FMT) is among the most popular microbiome intervention procedures. Current practices are to choose the transplanted microbiome based on the donor phenotype, and not based on the expected recipient phenotype. However, the two differ drastically. We here propose an algorithm to predict the expected outcome of FMT from the donor phenotype, and optimize the FMT for different required outcomes.
Results We here show, using multiple microbiome properties, that the donor and recipient phenotypes differ widely, and propose a tool to predict the recipient phenotype after the FMT using only the donors' microbiome and when available demographics for transplants from humans to either antibiotic treated mice, or other humans. We then extend the method to optimize the best-planned transplant (bacterial cocktails) by combining the predictor and a genetic algorithm (GA). We validate the predictor using a de-novo FMT experiment highlighting the possibility to choose transplants that optimize an array of required goals. We further show that a limited number of taxa is enough to produce an optimal FMT.
Conclusions Over the shelf FMT require recipient independent optimized FMT selection. Such a transplant can be from an optimal donor, or from a cultured set of microbes. We have here shown the feasibility of both types of donations in antibiotic treated mice and for transplants between humans.
Partial Discharge Signal De-noising in Power Transformer by Applying Radial Basis Function Network
Authors: Khavari Ehsan , Hosseini S. M. Hassan Hosseini , Gharehpetian Gevork B.
Published: November 2022

The noise interferes with the measuring equipment installed in transformer stations and results in technical challenges for utility engineers. Sensors are mounted on transformers, to measure partial discharge (PD) signals, but the noise deforms the PD signals. In this paper, the noise removal from PD signal of power transformers is performed by a radial basis function (RBF) neural network. The CST software is used to simulate a transformer, PD and noise. Also, a laboratory model is used to generate the PD and noise signals. The simulation and measurement results are presented and discussed. It is shown that the proposed method is a good technique for noise removal from PD signals.
A two-phase branch-and-bound algorithm for seru scheduling problems with sequence-dependent setup time
Authors: Zhang Xiaohong , Zhang Zhe , Gong Xue , Yin Yong
Published: November 2022

This paper focuses on seru scheduling problems considering the sequence-dependent setup time in seru production system (SPS), which is a new-type manufacturing system originated in Japanese production practice recently that can better adapt to the fluctuate market demand. A mixed integer programming (MIP) model with the objective of minimizing the sum of the makespan and the weighted tardiness is constructed for the seru scheduling problem. The two-phase B&B (TPBB) algorithm is designed subsequently, where the first phase solves the assignment of products to serus , while the second phase solves the scheduling optimization in each seru . Finally, the computational experiments and comparative analysis with CPLEX 12.8 are made, and the report of results verifies that the effectiveness and practicability of the proposed MIP model and TPBB algorithm.
FINANCIAL INCLUSION AS A DRIVER PROVIDING FINANCIAL SECURITY IN UKRAINE
Authors: Tatar M. , Dziubenko O. , Ostroushkina N.
Published: November 2022

The article considers the concept of monitoring, describes the types of monitoring by different classification criteria. It is proposed to consider monitoring as a constant, systematic observation of the main quantitative and qualitative parameters of economic entities with elements of analysis, evaluation and forecasting, taking into account environmental, external and internal factors. The subjects of interaction and the main issues that interest them, as well as the tools of interaction are identified. The method of rating assessment of expediency and reliability of interaction with subjects of external environment is offered on the basis of such indicators as interest of the partner in cooperation, experience of interaction of participants of the conflict, trust in relations with the partner, long-term partnerships, efficiency of feedback, technical compatibility, compatibility of individual and collective goals, speed of partner's reaction to changes, business reputation of partner, price competitiveness of partner, competitiveness of partner on terms of order fulfillment, competitiveness of partner on qualitative parameters, closeness of interrelation. The availability of equipment and material and technical base; the availability of employees with appropriate qualifications who have the necessary knowledge and experience; availability of documented experience in the implementation of similar agreements; availability of financial security must also be taken into account. The proposed method will assess the reliability of partners, the feasibility of interaction with them; will make possible to choose the optimal variant of participants in the interaction, methods of organizing effective and reliable relationships with them on the basis of the results of rating assessment. The level of efficiency of the monitoring system is determined, the essence of which is to save costs or increase income at the lowest cost of its implementation due to decision-making based on monitoring results. Timely detection of crisis situations in interaction is ensured by the introduction of effective monitoring systems that can structurally respond to significant dynamics of changes in the current situation and operate in conditions of information uncertainty.
PROJECT METHODOLOGIES IN LOCAL GOVERNMENTS
Authors: Yevdokymova A. , Kravchenko I. , Baranov A. , Kubrak O.
Published: November 2022

In Ukraine, the changes concerning territorial communities and their development strategies are taking place at the legislative level. In accordance with this, local governments need to change the approach to their development, since there should be a long-term effect that can be monitored as well as its effectiveness evaluated. Project management, which is implemented by various methodologies, should be used to implement the development strategy of a particular territorial community. The project approach shows its effectiveness in different areas. At the same time, it is less represented in local government. The research studies the factors influencing the low level of project activities implementation in local governments in Ukraine. The case study of implementation of the project approach in the municipality of Sumy city while developing and implementing the Sumy City Development Strategy until 2030 is considered. General problems that arise during the project methodologies implementation in local governments and proposals for leveling them are identified. The research purpose is to analyze the use of project methodologies in local governments while creating development strategy for a territorial community. Nowadays, the requirements for the creation of development strategies of territorial communities have been adopted at the legislative level. These requirements should contain new criteria (e.g.: performance indicators), which were not mandatory before, and the officials often ignored them. Nowadays the existing approaches to strategy creation, and most importantly, its implementation, should be significantly revised, including reorientation from a short-term effect to a long-term one. In order this activity (development strategies creation) to be as effective as possible, it should be expedient for local governments to use project methodologies. The problem that we point out in the research is that there is a certain difficulty in project methodologies implementation in local governments while creating the development strategy for a territorial community.
ANALYSIS OF STAKEHOLDER INTERACTION PATTERNS IN IMPLEMENTING THE THIRD MISSION OF UNIVERSITIES AS AN ELEMENT OF LEADERSHIP STRATEGY DEVELOPMENT
Authors: Shvindina H. , Petrushenko Y. , Balahurovska I. , Onopriienko K.
Published: November 2022

Modern Ukrainian universities are at the stage of integration changes caused by forming a single European educational space. The processes of society humanization, which are actively taking place in the modern world, require the creation of conditions to form a developed and educated society. These conditions are created in universities, which fulfill three missions: providing quality education, conducting research, and promoting the development of the socio-economic sphere of society.
The article deals with the study of external stakeholders and the peculiarities of their interaction with educational institutions during the implementation of the third mission of universities. The study shows that analyzing external stakeholders and their properties allows them to interact effectively. Based on this analysis, it is possible to form effective models of interaction between the university and external stakeholders in the implementation of the third mission.
The paper describes the key external stakeholder of universities in the implementation of the third mission - the state. The article presents the main external stakeholders of universities, which are organizations of various forms of ownership. Given the urgency of the third mission, the peculiarities and characteristics of the researched external stakeholders of universities are analyzed. The studied stakeholders of universities are widespread in the Ukrainian practice of interaction of educational institutions with them.
The study presents effective patterns of interaction between universities and external stakeholders in the third mission. The process of managing the relationship between educational institutions and external stakeholders in implementing the third mission is described.
The proposed article considers the leadership qualities of university leaders with different management levels, which contribute to the formation of effective ways of interacting with external stakeholders. Emphasis is placed on the need for universities to communicate effectively with external stakeholders to understand their needs to meet them accurately.