bluuebunny/crossref_metadata_2025 huggingface dataset:
Tensions of Modernity: Privilege, Precarity, and Colonial Nostalgia among European Security Contractors in East Africa
Authors: Norman Jethro
Published: April 2023

Private security work can be a brutal world of short-term contracts, exploitation, and under-regulation, where the imperative of profit is expected to trump collective notions of military brotherhood. Why then do so many demobilized soldiers turn to it as a vocation? While a rich body of work has revealed the vulnerabilities of demobilized military life, ethnographic investigations into how contractors experience and make sense of precarity are less common. Drawing on fieldwork with military veterans of European descent working and living in East Africa, this article argues that a central, yet underexplored, feature of contemporary security work is colonial nostalgia. Some contractors read the travelogues of colonial adventurers, while others trace their family genealogy to ancestral colonial frontier soldiers. A few even write their own memoirs in similar fashion. Writing, reading, and living the colonial past through this contractor canon serves several present-day functions. First, the parallels between risk-taking colonial adventurers and the kind of rugged individualism associated with homo economicus masks the tensions and fissures that emerge from soldiers’ discharge from the military and subsequent remobilization as privatized contractors. Secondly, colonial nostalgia forms part of a larger political critique of Western military interventions, of which many of these contractors experienced first-hand. Here, private security work is imagined as replicating an older, more effective tradition of frontier soldiering that is rooted in a logic of settler-colonialism. Finally, fantasies of a colonial past feed into contractors’ attempts to market themselves to clients and to organize their everyday work.
Southernmost occurrence of Gobiosoma hemigymnum (Eigenmann & Eigenmann, 1888) on salt marshes of the Bahia Blanca estuary, Argentina: an unusual finding
Authors: Molina Lucas M. , González Dubox M. Cecilia , Lopez Cazorla Andrea
Published: April 2023

Salt marshes do not present favourable conditions for cryptic fish species to inhabit these areas, mainly due to dryness and high temperatures at low tides, and scarce places to hide. Despite the harsh environmental conditions, we report, for the first time, the occurrence of two specimens of the half-naked goby Gobiosoma hemigymnum at high marsh, between oysters and Spartina alteniflora stems. In this paper we report evidence of a possible positive effect of autogenic ecosystem engineer and invasive species, the Pacific oyster (Magallana gigas), over the gobid, Gobiosoma hemigymnum, found 600 km away from its southernmost normal range.
Does learning to play an instrument have an impact on change in attainment from age 11 to 16?
Authors: Baker David , Hallam Susan , Rogers Kevin
Published: April 2023

Much previous international research has demonstrated links between general school attainment and active engagement with music. The research reported here compared the change in examination outcomes in English and mathematics in national examinations at ages 11 and 16 of instrumentalists and non-instrumentalists. Data from 701 pupils showed statistically significant differences in examination outcomes between instrumentalists and non-instrumentalists, which was also related to the duration of learning and the instrument played. Instrumentalists had greater change scores in mathematics, but not English, although instrumentalists of lower socio-economic status showed greater change in both subjects. The implications for music education are discussed.
Self-Validation Theory: Confidence can Increase but also Decrease Performance in Applied Settings
Authors: Briñol Pablo , Petty Richard E. , Moreno Lorena , Gandarillas Beatriz
Published: April 2023

This article presentsself-validation theory(SVT) as a framework predicting when mental contents guide performance. First, we illustrate how confidence can validate people’s thoughts (goals, beliefs, identity) increasing and decreasing performance, depending on what thoughts are validated. This first section reviews examples of validation processes in guiding intellectual performance in academic settings, sport performance in athletes, as well as performance on diverse social tasks. SVT specifies moderating conditions for validation processes to operate. Therefore, in the second section of this review, we identify unique and testable moderators for metacognitive processes demonstrating when and for whom validation processes are more likely to occur. A third section calls for future research identifying new validating variables (e.g., preparation, courage) capable of increasing usage of unexplored thoughts relevant to performance (e.g., expectations). This final section examines new domains for validation (e.g., group performance, cheating in performance), discusses to what extent people can use self-validation strategies deliberatively to improve their performance and addresses when performance can be impaired by invalidation (e.g., due to identity threat).
Operations Eclipse Sequencing in Multipurpose Dam Planning
Authors: Arnold Wyatt , Salazar Jazmin Z. , Carlino Angelo , Giuliani Matteo , Castelletti Andrea
Published: April 2023

A resurgence of dam planning and construction is under way in river basins where untapped hydropower potential could meet growing energy demands. Despite calls for more comprehensive evaluation of dam projects, most dams continue to be planned with traditional methods that neglect interdependencies between planning and management and cumulative impacts of multiple new dams. Using the transboundary Zambezi Watercourse as a case study where competing demands for water, energy, and food are increasing, we contribute to a novel dam planning approach that integrates sequencing of planned reservoirs with adaptive operations. While additional hydropower capacity reduces structural energy deficits, operating polices emerge as the main driver of human‐environmental tradeoffs, so much so that single‐objective operating policy selection may lead to erroneous perceptions of tradeoffs across infrastructure options. Furthermore, compared to an operation and sequencing strategy that singularly maximizes hydropower, seeking compromise through operations while constructing dams early improves environmental and irrigation objectives by 50% and 80% with an 8% loss in hydropower. Alternatively, seeking compromise only through delayed dam construction yields modest environmental and irrigation improvements of 6% and 9%, respectively, with a 22% loss in hydropower. The robustness of this result is tested under an ensemble of stochastic streamflow where environmental flow and irrigation deficits are found more sensitive to operations than shifts in water availability. The predominance of operating policies is relevant for improving multi‐objective dam planning in other river basins already fragmented by dams built in the twentieth century.
Geoelectric Characterization of Hyporheic Exchange Flow in the Bedrock‐Lined Streambed of East Fork Poplar Creek, Oak Ridge, Tennessee
Authors: Ikard Scott J. , Carroll Kenneth C. , Rucker Dale F. , Adams Ryan F. , Brooks Scott C.
Published: April 2023

A multimethod geoelectric survey was implemented between January and March 2022 along a 220‐m long reach of the bedrock‐lined streambed of East Fork Poplar Creek in Oak Ridge, Tennessee to identify locations of surface‐water and groundwater exchange and characterize the subsurface flow paths that convey water between the stream and flood plain. A waterborne self‐potential (WaSP) survey was completed in January 2022 to measure the electric streaming‐potential field in the stream. Electric resistivity tomography (ERT) was performed in March 2022 on the flood plain adjacent to the WaSP survey reach to map the electric resistivity distribution and characterize the hydrogeology and subsurface flow paths that facilitate surface‐water and groundwater exchange in the bedrock‐lined stream. The combination of WaSP and ERT data support the qualitative interpretation that surface‐water and groundwater exchange likely occurs along fractures in outcropping bedrock and along two fault lines that intersect the limestone creek bed.
Combining Triple‐Moment Ice With Prognostic Liquid Fraction in the P3 Microphysics Scheme: Impacts on a Simulated Squall Line
Authors: Cholette Mélissa , Milbrandt Jason A. , Morrison Hugh , Paquin‐Ricard Danahé , Jacques Dominik
Published: April 2023

The Predicted Particle Properties (P3) bulk microphysics scheme has been recently modified to combine the two major innovations. The triple‐moment approach to represent ice, allowing for a freely evolving spectral dispersion of the size distribution, is combined with the predicted liquid fraction, which enables an explicit representation of mixed‐phase particles. The impacts of this combination are examined in the context of high‐resolution (1‐km horizontal grid spacing) simulations of an observed mid‐latitude squall line using the Global Environmental Multiscale atmospheric model. The simulation of mixed‐phase particles results in a faster squall line propagation speed and stronger cold pool due to greater cooling from the microphysical processes of sublimation, melting and evaporation. There is a reduction in the mass of ice reaching the surface resulting from a decrease in the mean size of melting ice particles aloft with the predicted liquid fraction. Compared to the original double‐moment configuration, triple‐moment P3 configuration results in larger mean ice sizes at the surface. The reflectivity structure is improved with the new version, now with a more pronounced bright band in the melting zone with the predicted liquid fraction.
Linking Stream Chemistry to Subsurface Redox Architecture
Authors: Shaughnessy Andrew R. , Forgeng Michael J. , Wen Tao , Gu Xin , Hemingway Jordon D. , Brantley Susan L.
Published: April 2023

As drinking‐water scarcity grows worldwide, we need to improve predictions of the quantity and quality of our water resources. An overarching problem for model improvement is that we do not know the geological structure of aquifers in sufficient detail. In this work, we demonstrate that mineral‐water reactions imprint structure in the subsurface that impacts the flow and transport of some chemical species. Specifically, pyrite, a ubiquitous mineral, commonly oxidizes and depletes in the upper layers of the weathering profile in most humid watersheds, only remaining at depths of meters. We hypothesize that variations in concentrations (C) of pyrite‐derived sulfate released into rivers as a function of discharge (q) reflect the rate‐limiting step and depth of pyrite‐oxidizing layers. We found that log C − log q behaviors thus differ in small and large watersheds in the Susquehanna River Basin as well as in selected watersheds in the Western United States. Although coal mining changes pyrite oxidation from closed to open system with respect to O2, patterns in stream chemistry as a function of discharge are consistent with deep and shallow pyrite oxidation zones in small and large watersheds respectively. Therefore, understanding the subsurface patterns of mineral reactions and how they affect the architecture of aquifers will elucidate patterns of changing river chemistry and our ability to manage water resources in the future under accelerated land use and climate change.
Clouds Increasingly Influence Arctic Sea Surface Temperatures as CO2 Rises
Authors: Sledd A. , L’Ecuyer T. S. , Kay J. E. , Steele M.
Published: April 2023

As Arctic sea ice retreats during the melt season, the upper ocean warms in response to atmospheric heat fluxes. Overall, clouds reduce these fluxes in summer, but how the radiative impacts of clouds on ocean warming could change as sea ice declines has not been documented. In global climate model simulations with variable CO2, the timing of sea ice retreat strongly influences the amplitude of cloud‐induced summer cooling at the ocean surface. Under pre‐industrial CO2 concentrations, summer clouds have little direct effect on maximum annual sea surface temperatures (SST). When CO2 concentrations increase, sea ice retreats earlier, allowing more solar radiation to warm the ocean. Clouds can counteract this summer warming by reflecting solar radiation back to space. Consequently, clouds explain up to 13% more variability in maximum annual SST under modern‐day CO2 concentrations. Maximum annual SST are three times more sensitive to summer clouds when CO2 concentrations are four times pre‐industrial levels.
Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions
Authors: Ma Jun , Li Yanan , Yang Xiangyu , Liu Kai , Zhang Xin , Zuo Xianghao , Ye Runyu , Wang Ziqiong , Shi Rufeng , Meng Qingtao , Chen Xiaoping
Published: April 2023

Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research, hypertension remains difficult to cure due to its complex mechanisms involving multiple interactive factors and our limited understanding of it. Hypertension is a condition that is named after its clinical features. Vascular function is a factor that affects blood pressure directly, and it is a main strategy for clinically controlling BP to regulate constriction/relaxation function of blood vessels. Vascular elasticity, caliber, and reactivity are all characteristic indicators reflecting vascular function. Blood vessels are composed of three distinct layers, out of which the endothelial cells in intima and the smooth muscle cells in media are the main performers of vascular function. The alterations in signaling pathways in these cells are the key molecular mechanisms underlying vascular dysfunction and hypertension development. In this manuscript, we will comprehensively review the signaling pathways involved in vascular function regulation and hypertension progression, including calcium pathway, NO-NOsGC-cGMP pathway, various vascular remodeling pathways and some important upstream pathways such as renin-angiotensin-aldosterone system, oxidative stress-related signaling pathway, immunity/inflammation pathway, etc. Meanwhile, we will also summarize the treatment methods of hypertension that targets vascular function regulation and discuss the possibility of these signaling pathways being applied to clinical work.
A tissue specific-infection mouse model of SARS-CoV-2
Authors: Yang Bo , Liu Chao , Ju Xiaohui , Wu Bingbing , Wang Zhuangfei , Dong Fucheng , Yu Yanying , Hou Xiaohui , Fang Min , Gao Fei , Guo Xuejiang , Gui Yaoting , Ding Qiang , Li Wei
Published: April 2023

Animal models play crucial roles in the rapid development of vaccines/drugs for the prevention and therapy of COVID-19, but current models have some deficits when studying the pathogenesis of SARS-CoV-2 on some special tissues or organs. Here, we generated a human ACE2 and SARS-CoV-2 NF/F knockin mouse line that constitutively expresses human ACE2 and specifically expresses SARS-CoV-2 N gene induced by Cre-recombinase. By crossing with Cre transgenic lines allowing for lung-specific and constitutive expression, we generated lung-specific (Sftpc-hACE2-NF/F) and constitutive SARS-CoV-2 N (EIIa-hACE2-NF/F) expressing mice. Upon intranasal infection with a SARS-CoV-2 GFP/ΔN strain which can only replicate in SARS-CoV-2 N expressed cells, we demonstrated that both the Sftpc-hACE2-NF/F and EIIa-hACE2-NF/F mice support viral replication. Consistent with our design, viral replication was limited to the lung tissues in Sftpc-hACE2-NF/F mice, while the EIIa-hACE2-NF/F mice developed infections in multiple tissues. Furthermore, our model supports different SARS-CoV-2 variants infection, and it can be successfully used to evaluate the effects of therapeutic monoclonal antibodies (Ab1F11) and antiviral drugs (Molnupiravir). Finally, to test the effect of SARS-CoV-2 infection on male reproduction, we generated Sertoli cell-specific SARS-CoV-2 N expressed mice by crossing with AMH-Cre transgenic line. We found that SARS-CoV-2 GFP/ΔN strain could infect Sertoli cells, led to spermatogenic defects due to the destruction of blood-testis barrier. Overall, combining with different tissue-specific Cre transgenic lines, the human ACE2 and SARS-CoV-2 NF/F line enables us to evaluate antivirals in vivo and study the pathogenesis of SARS-CoV-2 on some special tissues or organs.
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology
Authors: Ziff Oliver J. , Neeves Jacob , Mitchell Jamie , Tyzack Giulia , Martinez-Ruiz Carlos , Luisier Raphaelle , Chakrabarti Anob M. , McGranahan Nicholas , Litchfield Kevin , Boulton Simon J. , Al-Chalabi Ammar , Kelly Gavin , Humphrey Jack , Patani Rickie
Published: April 2023

Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97% of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been hampered by disease heterogeneity and difficulties accessing motor neurons. Human induced pluripotent stem cell-derived motor neurons (iPSMNs) offer a solution; however, studies have typically been limited to underpowered cohorts. Here, we present a comprehensive compendium of 429 iPSMNs from 15 datasets, and 271 post-mortem spinal cord samples. Using reproducible bioinformatic workflows, we identify robust upregulation of p53 signalling in ALS in both iPSMNs and post-mortem spinal cord. p53 activation is greatest withC9orf72repeat expansions but is weakest with SOD1 and FUS mutations. TDP-43 depletion potentiates p53 activation in both post-mortem neuronal nuclei and cell culture, thereby functionally linking p53 activation with TDP-43 depletion. ALS iPSMNs and post-mortem tissue display enrichment of splicing alterations, somatic mutations, and gene fusions, possibly contributing to the DNA damage response.
Hippocampal sharp wave ripples underlie stress susceptibility in male mice
Authors: Kuga Nahoko , Nakayama Ryota , Morikawa Shota , Yagishita Haruya , Konno Daichi , Shiozaki Hiromi , Honjoya Natsumi , Ikegaya Yuji , Sasaki Takuya
Published: April 2023

The ventral hippocampus (vHC) is a core brain region for emotional memory. Here, we examined how the vHC regulates stress susceptibility from the level of gene expression to neuronal population dynamics in male mice. Transcriptome analysis of samples from stress-naïve mice revealed that intrinsic calbindin (Calb1) expression in the vHC is associated with susceptibility to social defeat stress. Mice with Calb1 gene knockdown in the vHC exhibited increased stress resilience and failed to show the increase in the poststress ventral hippocampal sharp wave ripple (SWR) rate. Poststress vHC SWRs triggered synchronous reactivation of stress memory-encoding neuronal ensembles and facilitated information transfer to the amygdala. Suppression of poststress vHC SWRs by real-time feedback stimulation or walking prevented social behavior deficits. Taken together, our results demonstrate that internal reactivation of memories of negative stressful episodes supported by ventral hippocampal SWRs serves as a crucial neurophysiological substrate for determining stress susceptibility.
Bird tolerance to humans in open tropical ecosystems
Authors: Mikula Peter , Tomášek Oldřich , Romportl Dušan , Aikins Timothy K. , Avendaño Jorge E. , Braimoh-Azaki Bukola D. A. , Chaskda Adams , Cresswell Will , Cunningham Susan J. , Dale Svein , Favoretto Gabriela R. , Floyd Kelvin S. , Glover Hayley , Grim Tomáš , Henry Dominic A. W. , Holmern Tomas , Hromada Martin , Iwajomo Soladoye B. , Lilleyman Amanda , Magige Flora J. , Martin Rowan O. , de A. Maximiano Marina F. , Nana Eric D. , Ncube Emmanuel , Ndaimani Henry , Nelson Emma , van Niekerk Johann H. , Pienaar Carina , Piratelli Augusto J. , Pistorius Penny , Radkovic Anna , Reynolds Chevonne , Røskaft Eivin , Shanungu Griffin K. , Siqueira Paulo R. , Tarakini Tawanda , Tejeiro-Mahecha Nattaly , Thompson Michelle L. , Wamiti Wanyoike , Wilson Mark , Tye Donovan R. C. , Tye Nicholas D. , Vehtari Aki , Tryjanowski Piotr , Weston Michael A. , Blumstein Daniel T. , Albrecht Tomáš
Published: April 2023

Animal tolerance towards humans can be a key factor facilitating wildlife–human coexistence, yet traits predicting its direction and magnitude across tropical animals are poorly known. Using 10,249 observations for 842 bird species inhabiting open tropical ecosystems in Africa, South America, and Australia, we find that avian tolerance towards humans was lower (i.e., escape distance was longer) in rural rather than urban populations and in populations exposed to lower human disturbance (measured as human footprint index). In addition, larger species and species with larger clutches and enhanced flight ability are less tolerant to human approaches and escape distances increase when birds were approached during the wet season compared to the dry season and from longer starting distances. Identification of key factors affecting animal tolerance towards humans across large spatial and taxonomic scales may help us to better understand and predict the patterns of species distributions in the Anthropocene.
Copper-catalyzed asymmetric C(sp2)–H arylation for the synthesis of P- and axially chiral phosphorus compounds
Authors: Yan Shao-Bai , Wang Rui , Li Zha-Gen , Li An-Na , Wang Chuanyong , Duan Wei-Liang
Published: April 2023

Transition metal-catalyzed C–H bond functionalization is an important method in organic synthesis, but the development of methods that are lower cost and have a less environmental impact is desirable. Here, a Cu-catalyzed asymmetric C(sp2)–H arylation is reported. With diaryliodonium salts as arylating reagents, a range of ortho-arylated P-chiral phosphonic diamides were obtained in moderate to excellent yields with high enantioselectivities (up to 92% ee). Meanwhile, enantioselective C-3 arylation of diarylphosphine oxide indoles was also realized under similar conditions to construct axial chirality.
Exploiting nonaqueous self-stratified electrolyte systems toward large-scale energy storage
Authors: Wang Zhenkang , Ji Haoqing , Zhou Jinqiu , Zheng Yiwei , Liu Jie , Qian Tao , Yan Chenglin
Published: April 2023

Biphasic self-stratified batteries (BSBs) provide a new direction in battery philosophy for large-scale energy storage, which successfully reduces the cost and simplifies the architecture of redox flow batteries. However, current aqueous BSBs have intrinsic limits on the selection range of electrode materials and energy density due to the narrow electrochemical window of water. Thus, herein, we develop nonaqueous BSBs based on Li-S chemistry, which deliver an almost quadruple increase in energy density of 88.5 Wh L−1 as compared with the existing aqueous BSBs systems. In situ spectral characterization and molecular dynamics simulations jointly elucidate that while ensuring the mass transfer of Li+, the positive redox species are strictly confined to the bottom-phase electrolyte. This proof-of-concept of Li-S BSBs pushes the energy densities of BSBs and provides an idea to realize massive-scale energy storage with large capacitance.
A non-Newtonian fluid quasi-solid electrolyte designed for long life and high safety Li-O2 batteries
Authors: Zheng Guangli , Yan Tong , Hong Yifeng , Zhang Xiaona , Wu Jianying , Liang Zhenxing , Cui Zhiming , Du Li , Song Huiyu
Published: April 2023

The Li dendrite growth and the liquid electrolyte volatilization under semi-open architecture are intrinsic issues for Li-O2 battery. In this work, we propose a non-Newtonian fluid quasi-solid electrolyte (NNFQSE) SiO2-SO3Li/PVDF-HFP, which has both shear-thinning and shear-thickening properties. The component interactions among the sulfonated silica nanoparticles, liquid electrolyte, and polymer network are beneficial for decent Li+ conductivity and high liquid electrolyte retention without volatilization. Furthermore, NNFQSE exhibits shear-thinning property to eliminate the stress of dendrite growth during repeated cycling. Meanwhile, when the force suddenly increases, such as a high current rate, the NNFQSE may dynamically turn shear-thickening to respond and mechanically stiffen to inhibit the lithium dendrite penetration. By coupling with the NNFQSE, the lithium symmetrical battery can run over 2000 h under 1 mA cm−2 at room temperature, and the quasi-solid Li-O2 battery actualizes long life above 5000 h at 100 mA g−1.
Universal structures for adaptation in biochemical reaction networks
Authors: Araujo Robyn P. , Liotta Lance A.
Published: April 2023

At the molecular level, the evolution of life is driven by the generation and diversification of adaptation mechanisms. A universal description of adaptation-capable chemical reaction network (CRN) structures has remained elusive until now, since currently-known criteria for adaptation apply only to a tiny subset of possible CRNs. Here we identify the definitive structural requirements that characterize all adaptation-capable collections of interacting molecules, however large or complex. We show that these network structures implement a form of integral control in which multiple independent integrals can collaborate to confer the capacity for adaptation on specific molecules. Using an algebraic algorithm informed by these findings, we demonstrate the existence of embedded integrals in a variety of biologically important CRNs that have eluded previous methods, and for which adaptation has been observed experimentally. This definitive picture of biological adaptation at the level of intermolecular interactions represents a blueprint for adaptation-capable signaling networks across all domains of life, and for the design of synthetic biosystems.
Energy-efficient high-fidelity image reconstruction with memristor arrays for medical diagnosis
Authors: Zhao Han , Liu Zhengwu , Tang Jianshi , Gao Bin , Qin Qi , Li Jiaming , Zhou Ying , Yao Peng , Xi Yue , Lin Yudeng , Qian He , Wu Huaqiang
Published: April 2023

Medical imaging is an important tool for accurate medical diagnosis, while state-of-the-art image reconstruction algorithms raise critical challenges in massive data processing for high-speed and high-quality imaging. Here, we present a memristive image reconstructor (MIR) to greatly accelerate image reconstruction with discrete Fourier transformation (DFT) by computing-in-memory (CIM) with memristor arrays. A high-accuracy quasi-analogue mapping (QAM) method and generic complex matrix transfer (CMT) scheme was proposed to improve the mapping precision and transfer efficiency, respectively. High-fidelity magnetic resonance imaging (MRI) and computed tomography (CT) image reconstructions were demonstrated, achieving software-equivalent qualities and DICE scores after segmentation with nnU-Net algorithm. Remarkably, our MIR exhibited 153× and 79× improvements in energy efficiency and normalized image reconstruction speed, respectively, compared to graphics processing unit (GPU). This work demonstrates MIR as a promising high-fidelity image reconstruction platform for future medical diagnosis, and also largely extends the application of memristor-based CIM beyond artificial neural networks.
Metagenome and metabolome insights into the energy compensation and exogenous toxin degradation of gut microbiota in high-altitude rhesus macaques (Macaca mulatta)
Authors: Zhao Junsong , Yao Yongfang , Li Diyan , Zhu Wei , Xiao Hongtao , Xie Meng , Xiong Ying , Wu Jiayun , Ni Qingyong , Zhang Mingwang , Xu Huailiang
Published: April 2023

There have been many reports on the genetic mechanism in rhesus macaques (RMs) for environmental adaptation to high altitudes, but the synergistic involvement of gut microbiota in this adaptation remains unclear. Here we performed fecal metagenomic and metabolomic studies on samples from high- and low-altitude populations to assess the synergistic role of gut microbiota in the adaptation of RMs to high-altitude environments. Microbiota taxonomic annotation yielded 7471 microbiota species. There were 37 bacterial species whose abundance was significantly enriched in the high-altitude populations, 16 of which were previously reported to be related to the host’s dietary digestion and energy metabolism. Further functional gene enrichment found a stronger potential for gut microbiota to synthesize energy substrate acetyl-CoA using CO2 and energy substrate pyruvate using oxaloacetate, as well as a stronger potential to transform acetyl-CoA to energy substrate acetate in high-altitude populations. Interestingly, there were no apparent differences between low-altitude and high-altitude populations in terms of genes enriched in the main pathways by which the microbiota consumed the three energy substrates, and none of the three energy substrates were detected in the fecal metabolites. These results strongly suggest that gut microbiota plays an important energy compensatory role that helps RMs to adapt to high-altitude environments. Further functional enrichment after metabolite source analysis indicated the abundance of metabolites related to the degradation of exogenous toxins was also significantly higher in high-altitude populations, which suggested a contributory role of gut microbiota to the degradation of exogenous toxins in wild RMs adapted to high-altitude environments.
A history of mild shocks experienced by the regolith particles on hydrated asteroid Ryugu
Authors: Tomioka Naotaka , Yamaguchi Akira , Ito Motoo , Uesugi Masayuki , Imae Naoya , Shirai Naoki , Ohigashi Takuji , Kimura Makoto , Liu Ming-Chang , Greenwood Richard C. , Uesugi Kentaro , Nakato Aiko , Yogata Kasumi , Yuzawa Hayato , Kodama Yu , Hirahara Kaori , Sakurai Ikuya , Okada Ikuo , Karouji Yuzuru , Okazaki Keishi , Kurosawa Kosuke , Noguchi Takaaki , Miyake Akira , Miyahara Masaaki , Seto Yusuke , Matsumoto Toru , Igami Yohei , Nakazawa Satoru , Okada Tatsuaki , Saiki Takanao , Tanaka Satoshi , Terui Fuyuto , Yoshikawa Makoto , Miyazaki Akiko , Nishimura Masahiro , Yada Toru , Abe Masanao , Usui Tomohiro , Watanabe Sei-ichiro , Tsuda Yuichi
Published: April 2023

Micrometeorites, a possible major source of Earth’s water, are thought to form from explosive dispersal of hydrated chondritic materials during impact events on their parental asteroids. However, this provenance and formation mechanism have yet to be directly confirmed using asteroid returned samples. Here, we report evidence of mild shock metamorphism in the surface particles of asteroid Ryugu based on electron microscopy. All particles are dominated by phyllosilicates but lack dehydration textures, which are indicative of shock-heating temperatures below ~500 °C. Microfault-like textures associated with extensively shock-deformed framboidal magnetites and a high-pressure polymorph of Fe–Cr–sulfide have been identified. These findings indicate that the average peak pressure was ~2 GPa. The vast majority of ejecta formed during impact on Ryugu-like asteroids would be hydrated materials, larger than a millimetre, originating far from the impact point. These characteristics are inconsistent with current micrometeorite production models, and consequently, a new formation mechanism is required.
Structural basis of centromeric cohesion protection
Authors: García-Nieto Alberto , Patel Amrita , Li Yan , Oldenkamp Roel , Feletto Leonardo , Graham Joshua J. , Willems Laureen , Muir Kyle W. , Panne Daniel , Rowland Benjamin D.
Published: April 2023

In the early stages of mitosis, cohesin is released from chromosome arms but not from centromeres. The protection of centromeric cohesin by SGO1 maintains the sister chromatid cohesion that resists the pulling forces of microtubules until all chromosomes are attached in a bipolar manner to the mitotic spindle. Here we present the X-ray crystal structure of a segment of human SGO1 bound to a conserved surface of the cohesin complex. SGO1 binds to a composite interface formed by the SA2 and SCC1RAD21 subunits of cohesin. SGO1 shares this binding interface with CTCF, indicating that these distinct chromosomal regulators control cohesin through a universal principle. This interaction is essential for the localization of SGO1 to centromeres and protects centromeric cohesin against WAPL-mediated cohesin release. SGO1–cohesin binding is maintained until the formation of microtubule–kinetochore attachments and is required for faithful chromosome segregation and the maintenance of a stable karyotype.
CRAFTED: An exploratory database of simulated adsorption isotherms of metal-organic frameworks
Authors: Oliveira Felipe Lopes , Cleeton Conor , Neumann Barros Ferreira Rodrigo , Luan Binquan , Farmahini Amir H. , Sarkisov Lev , Steiner Mathias
Published: April 2023

Grand Canonical Monte Carlo is an important method for performing molecular-level simulations and assisting the study and development of nanoporous materials for gas capture applications. These simulations are based on the use of force fields and partial charges to model the interaction between the adsorbent molecules and the solid framework. The choice of the force field parameters and partial charges can significantly impact the results obtained, however, there are very few databases available to support a comprehensive impact evaluation. Here, we present a database of simulations of CO2 and N2 adsorption isotherms on 690 metal-organic frameworks taken from the CoRE MOF 2014 database. We performed simulations with two force fields (UFF and DREIDING), six partial charge schemes (no charges, Qeq, EQeq, MPNN, PACMOF, and DDEC), and three temperatures (273, 298, 323 K). The resulting isotherms compose the Charge-dependent, Reproducible, Accessible, Forcefield-dependent, and Temperature-dependent Exploratory Database (CRAFTED) of adsorption isotherms.
Product, building, and infrastructure material stocks dataset for 337 Chinese cities between 1978 and 2020
Authors: Li Xiang , Song Lulu , Liu Qiance , Ouyang Xin , Mao Ting , Lu Haojie , Liu Litao , Liu Xiaojie , Chen Weiqiang , Liu Gang
Published: April 2023

Reliable city-level product, building, and infrastructure material stocks data are essential for understanding historical material use patterns, benchmarking material efficiency, and informing future recycling potentials. However, such urban material stocks data are often limited, due primarily to unavailable, inconsistent, or noncontinuous city-level statistics. Here, we provided such an Urban Product, Building, and Infrastructure Material Stocks (UPBIMS) dataset for China, a country that has undergone a remarkable urbanization process in the past decades, by collating different official statistics and applying various gap-filling methods. This dataset contains the stock of 24 materials contained in 10 types of products, buildings, and infrastructure in all 337 prefecture-level cities in China from 1978 to 2020. This quality controlled and unified dataset is the first of its kind with such a full coverage of all prefecture-level Chinese cities and can be used in a variety of applications, for example in urban geography, industrial ecology, circular economy, and climate change mitigation. Every piece of data is tagged with its source and the dataset will be periodically updated.
The intracellular domain of major histocompatibility class-I proteins is essential for maintaining excitatory spine density and synaptic ultrastructure in the brain
Authors: Lazarczyk Maciej J. , Eyford Brett A. , Varghese Merina , Arora Hitesh , Munro Lonna , Warda Tahia , Pfeifer Cheryl G. , Sowa Allison , Dickstein Daniel R. , Rumbell Timothy , Jefferies Wilfred A. , Dickstein Dara L.
Published: April 2023

Major histocompatibility complex class I (MHC-I) proteins are expressed in neurons, where they regulate synaptic plasticity. However, the mechanisms by which MHC-I functions in the CNS remains unknown. Here we describe the first structural analysis of a MHC-I protein, to resolve underlying mechanisms that explains its function in the brain. We demonstrate that Y321F mutation of the conserved cytoplasmic tyrosine-based endocytosis motif YXXΦ in MHC-I affects spine density and synaptic structure without affecting neuronal complexity in the hippocampus, a region of the brain intimately involved in learning and memory. Furthermore, the impact of the Y321F substitution phenocopies MHC-I knock-out (null) animals, demonstrating that reverse, outside-in signalling events sensing the external environment is the major mechanism that conveys this information to the neuron and this has a previously undescribed yet essential role in the regulation of synaptic plasticity.
Uncovering spatial and social gaps in rural mobility via mobile phone big data
Authors: Liu Zhengying , Zhao Pengjun , Liu Qiyang , He Zhangyuan , Kang Tingting
Published: April 2023

Rural mobility inequality is an important aspect of inequality-focused Sustainable Development Goals. To reduce inequality and promote global sustainable development, more insight is needed into human mobility patterns in rural areas. However, studies on rural human mobility are scarce, limiting our understanding of the spatial and social gaps in rural human mobility and our ability to design policies for social equality and global sustainable development. This study, therefore, explores human mobility patterns in rural China using mobile phone data. Mapping the relative frequency of short-distance trips across rural towns, we observed that geographically peripheral populations tend to have a low percentage of short-distance flows. We further revealed social gaps in mobility by fitting statistical models: as travel distances increased, human movements declined more rapidly among vulnerable groups, including children, older people, women, and low-income people. In addition, we found that people living with low street density, or in rural towns in peripheral cities with long distances to city borders, are more likely to have low intercity movement. Our results show that children, older adults, women, low-income individuals, and geographically peripheral populations in rural areas are mobility-disadvantaged, providing insights for policymakers and rural planners for achieving social equality by targeting the right groups.
Long-term impact of pulses and organic amendments inclusion in cropping system on soil physical and chemical properties
Authors: Nath C. P. , Dutta Asik , Hazra K. K. , Praharaj C. S. , Kumar Narendra , Singh S. S. , Singh Ummed , Das Krishnashis
Published: April 2023

Mono-cropping of maize–wheat, mechanical disintegration of soils, and continuous chemical fertilization have deteriorated soil health in the Indo-Gangetic Plains. We studied the long-term impact of pulse-based cropping systems with integrated nutrient management on soil physical and chemical properties and yield sustainability. We evaluated four different cropping systems: (1) maize–wheat (M–W), (2) maize–wheat–mungbean (M–W–Mb), (3) maize–wheat–maize–chickpea (M–W–M–C), (4) pigeonpea–wheat (P–W) each with three degrees of soil fertilization techniques: (1) unfertilized control (CT), (2) inorganic fertilization (RDF), and (3) integrated nutrient management (INM). The field experiment was undertaken in a split-plot design with three replications each year with a fixed layout. P–W and M–W–Mb systems enhanced soil properties such as volume expansion by 9–25% and porosity by 7–9% (p < 0.05) more than M–W, respectively. P–W and M–W–Mb increased soil organic carbon by 25–42% and 12–50% over M–W (RDF). P–W system enhanced water holding capacity and gravimetric moisture content by 10 and 11% (p < 0.05) than M–W. Pulse-based systems (P–W and M–W–Mb) had higher available nitrogen (8–11%), phosphorus (42–73%), and potassium (8–12%) over M–W (p < 0.05). M–W–Mb increased 26% maize yield and 21% wheat yield over M–W (p < 0.05) at the thirteenth crop cycle. P–W system had a higher sustainable yield index (p < 0.05) of wheat over the M–W. Thus, pulse inclusion in the cropping system in combination with INM can enhance physical and chemical properties vis-à-vis sustainable yield index over the cereal-cereal system.
Encoding of speech in convolutional layers and the brain stem based on language experience
Authors: Beguš Gašper , Zhou Alan , Zhao T. Christina
Published: April 2023

Comparing artificial neural networks with outputs of neuroimaging techniques has recently seen substantial advances in (computer) vision and text-based language models. Here, we propose a framework to compare biological and artificial neural computations of spoken language representations and propose several new challenges to this paradigm. The proposed technique is based on a similar principle that underlies electroencephalography (EEG): averaging of neural (artificial or biological) activity across neurons in the time domain, and allows to compare encoding of any acoustic property in the brain and in intermediate convolutional layers of an artificial neural network. Our approach allows a direct comparison of responses to a phonetic property in the brain and in deep neural networks that requires no linear transformations between the signals. We argue that the brain stem response (cABR) and the response in intermediate convolutional layers to the exact same stimulus are highly similar without applying any transformations, and we quantify this observation. The proposed technique not only reveals similarities, but also allows for analysis of the encoding of actual acoustic properties in the two signals: we compare peak latency (i) in cABR relative to the stimulus in the brain stem and in (ii) intermediate convolutional layers relative to the input/output in deep convolutional networks. We also examine and compare the effect of prior language exposure on the peak latency in cABR and in intermediate convolutional layers. Substantial similarities in peak latency encoding between the human brain and intermediate convolutional networks emerge based on results from eight trained networks (including a replication experiment). The proposed technique can be used to compare encoding between the human brain and intermediate convolutional layers for any acoustic property and for other neuroimaging techniques.
Searching for sliding surfaces in multi-level loess slopes based on the brachistochrone
Authors: Yang Kui-bin , Zhu Yan-peng
Published: April 2023

As a key problem in slope-stability analysis, searching for potential sliding surfaces has attracted the attention of experts and scholars for a long time. However, the commonly used sliding surface curves are only considered in terms of shape approximation and lack physical significance. The search process involved in stability analysis of multi-level slopes is complex and a large amount of calculation is required. In order to solve this problem, this paper proposes a new sliding surface form based on physical interpretation of the brachistochrone, and establishes a search model for the brachistochrone sliding surface of a multi-level loess slope. At the same time, in order to further expand the search range and find a more ideal potential sliding surface curve shape and position with a lower safety factor, we recommend continuing the sliding-surface search after the brachistochrone is improved. We compared the calculation results for the position of the potential sliding surface and the stability safety factor with the corresponding results for an arc sliding surface (in combination with a calculation example) to verify its rationality. The approach offered here not only provides a new choice of sliding surface curve form for slope-stability analysis, but also significantly improves search efficiency for potential sliding surfaces of multi-level loess slopes.
Highly sensitive low-frequency-detectable acoustic sensor using a piezoresistive cantilever for health monitoring applications
Authors: Okamoto Yuki , Nguyen Thanh-Vinh , Takahashi Hidetoshi , Takei Yusuke , Okada Hironao , Ichiki Masaaki
Published: April 2023

This study investigates a cantilever-based pressure sensor that can achieve a resolution of approximately 0.2 mPa, over the frequency range of 0.1–250 Hz. A piezoresistive cantilever with ultra-high acoustic compliance is used as the sensing element in the proposed pressure sensor. We achieved a cantilever with a sensitivity of approximately 40 times higher than that of the previous cantilever device by realizing an ultrathin (340 nm thick) structure with large pads and narrow hinges. Based on the measurement results, the proposed pressure sensor can measure acoustic signals with frequencies as low as 0.1 Hz. The proposed pressure sensor can be used to measure low-frequency pressure and sound, which is crucial for various applications, including photoacoustic-based gas/chemical sensing and monitoring of physiological parameters and natural disasters. We demonstrate the measurement of heart sounds with a high SNR of 58 dB. We believe the proposed microphone will be used in various applications, such as wearable health monitoring, monitoring of natural disasters, and realization of high-resolution photoacoustic-based gas sensors. We successfully measured the first (S1) and second (S2) cardiac sounds with frequencies of 7–100 Hz and 20–45 Hz, respectively.
Effect of remdesivir post-exposure prophylaxis and treatment on pathogenesis of measles in rhesus macaques
Authors: Peart Akindele Nadine A. , Katamoni Laharika Dasharath , Brockhurst Jacqueline , Ghimire Shristi , Suwanmanee San , Pieterse Lisa , Metcalf Pate Kelly A. , Bunyan Elaine , Bannister Roy , Cihlar Tomas , Porter Danielle P. , Griffin Diane E.
Published: April 2023

Measles is a systemic disease initiated in the respiratory tract with widespread measles virus (MeV) infection of lymphoid tissue. Mortality can be substantial, but no licensed antiviral therapy is available. We evaluated both post-exposure prophylaxis and treatment with remdesivir, a broad-spectrum antiviral, using a well-characterized rhesus macaque model of measles. Animals were treated with intravenous remdesivir for 12 days beginning either 3 days after intratracheal infection (post-exposure prophylaxis, PEP) or 11 days after infection at the onset of disease (late treatment, LT). As PEP, remdesivir lowered levels of viral RNA in peripheral blood mononuclear cells, but RNA rebounded at the end of the treatment period and infectious virus was continuously recoverable. MeV RNA was cleared more rapidly from lymphoid tissue, was variably detected in the respiratory tract, and not detected in urine. PEP did not improve clinical disease nor lymphopenia and reduced the antibody response to infection. In contrast, LT had little effect on levels of viral RNA or the antibody response but also did not decrease clinical disease. Therefore, remdesivir transiently suppressed expression of viral RNA and limited dissemination when provided as PEP, but virus was not cleared and resumed replication without improvement in the clinical disease parameters evaluated.
Comparison of the neuromuscular response to three different Turkish, semi-professional football training sessions typically used within the tactical periodization training model
Authors: Garrett Joel M. , Leduc Cedric , Akyildiz Zeki , van den Hoek Daniel J. , Clemente Filipe Manuel , Yildiz Mehmet , Nobari Hadi
Published: April 2023

This study examined the neuromuscular responses to three typical football (soccer) training sessions and the reliability of peak speed (PS) measured during a submaximal running test (SRT) for identifying neuromuscular fatigue (NMF) status. Jump height (CMJH) and peak velocity (CMJPV) were collected from a CMJ test, while peak speed (PS) was collected during an SRT before and after each training session. Large effect size (ES) decreases were observed in each variable post-training (ES; − 1.42 to − 2.32). Significant differences (> 0.001) were detected between each football session's external load variables. Coefficients of variations were small (< 10%) with moderate (CMJPV; 0.53, PS; 0.44) and strong (CMJH; 0.72) intraclass correlation coefficients between pre-test measures. The demands of each football session aligned with the principles of tactical periodization and were sufficient to produce the fatigue necessary to elicit physiological adaptations. PS was also shown to be a viable measure of monitoring NMF status.