bluuebunny/crossref_metadata_2025 huggingface dataset:
Coronavirus misinformation and the political scenario: the science cannot be ‘another’ barrier
Authors: Simões Mendes Marcelo
Published: September 2020

The sensible and conflicting scenario of the pandemic postulated many challenges to societies around the world in 2020. Part of this problem refers to how the differences between politics and science are not comprehended in their particularities. The recognition of limits and power of science and politics can not only contribute to reaching the actions and strategies facing novel coronavirus but also optimized many domains of society.
Identification of potential specific biomarkers and key signaling pathways between osteogenic and adipogenic differentiation of hBMSCs for osteoporosis therapy
Authors: Wu Jianjun , Cai Peian , Lu Zhenhui , Zhang Zhi , He Xixi , Zhu Bikang , Zheng Li , Zhao Jinmin
Published: September 2020

Background

The differentiation of bone mesenchymal stem cells (BMSCs) into adipogenesis (AD) rather than osteogenesis (OS) is an important pathological feature of osteoporosis. Illuminating the detailed mechanisms of the differentiation of BMSCs into OS and AD would contribute to the interpretation of osteoporosis pathology.

Methods

To identify the regulated mechanism in lineage commitment of the BMSCs into OS and AD in the early stages, the gene expression profiles with temporal series were downloaded to reveal the distinct fates when BMSCs adopt a committed lineage. For both OS and AD lineages, the profiles of days 2–4 were compared with day 0 to screen the differentially expressed genes (DEGs), respectively. Next, the functional enrichment analysis was utilized to find out the biological function, and protein-protein interaction network to predict the central genes. Finally, experiments were performed to verify our finding.

Results

FoxO signaling pathway with central genes like FoxO3, IL6, and CAT is the crucial mechanism of OS, while Rap1 signaling pathway of VEGFA and FGF2 enrichment is more significant for AD. Besides, PI3K-Akt signaling pathway might serve as the latent mechanism about the initiation of differentiation of BMSCs into multiple lineages.

Conclusion

Above hub genes and early-responder signaling pathways control osteogenic and adipogenic fates of BMSCs, which maybe mechanistic models clarifying the changes of bone metabolism in the clinical progress of osteoporosis. The findings provide a crucial reference for the prevention and therapy of osteoporosis.
Adipocytes: active facilitators in epithelial ovarian cancer progression?
Authors: Dai Lan , Song Keqi , Di Wen
Published: September 2020

There is growing evidence that adipocytes play important roles in the progression of multiple cancers. Moreover, in obesity, adipocytes alter their original functions and contribute to the metabolic and inflammatory changes of adipose tissue microenvironment, which can further enhance tumor development. At present, the roles of adipocytes in the pathogenesis of epithelial ovarian cancer (EOC) are far from being fully elucidated. Herein, we summarized the recent advances in understanding the roles of adipocytes in EOC progression. Adipocytes, close neighbors of EOC tissue, promote EOC growth, invasion, metastasis and angiogenesis through adipokine secretion, metabolic remodeling and immune microenvironment modulation. Moreover, adipocytes are important therapeutic targets and may work as useful anticancer drug delivery depot for EOC treatment. Furthermore, adipocytes also act as a therapeutic obstacle for their involvement in EOC treatment resistance. Hence, better characterization of the adipocytes in EOC microenvironment and the crosstalk between adipocytes and EOC cells may provide insights into EOC progression and suggest novel therapeutic opportunities.
Enhanced biosurveillance of high-consequence invasive pests: southern cattle fever ticks, Rhipicephalus (Boophilus) microplus, on livestock and wildlife
Authors: Wang Hsiao-Hsuan , Grant William E. , Teel Pete D. , Lohmeyer Kimberly H. , A. Pérez de León Adalberto
Published: September 2020

Background

Some tick species are invasive and of high consequence to public and veterinary health. Socioeconomic development of rural parts of the USA was enabled partly through the eradication by 1943 of cattle fever ticks (CFT, Rhipicephalus (Boophilus) annulatus and R. (B.) microplus). The southern cattle fever ticks (SCFT, R. (B.) microplus) remain a real and present threat to the USA animal agriculture because they are established in Mexico. Livestock-wildlife interactions in the Permanent Quarantine Zone (PQZ) established by the century-old Cattle Fever Tick Eradication Programme (CFTEP) in south Texas endanger its operations.

Methods

We describe a spatially-explicit, individual-based model that simulates interactions between cattle, white-tailed deer (WTD, Odocoileus virginianus), and nilgai (Boselaphus tragocamelus) to assess the risk for SCFT infestations across the pathogenic landscape in the PQZ and beyond. We also investigate the potential role of nilgai in sustaining SCFT populations by simulating various hypothetical infestation and eradication scenarios.

Results

All infestation scenarios resulted in a phase transition from a relatively small proportion of the ranch infested to almost the entire ranch infested coinciding with the typical period of autumn increases in off-host tick larvae. Results of eradication scenarios suggest that elimination of all on-host ticks on cattle, WTD, or nilgai would have virtually no effect on the proportion of the ranch infested or on the proportions of different tick habitat types infested; the entire ranch would remain infested. If all on-host ticks were eliminated on cattle and WTD, WTD and nilgai, or cattle and nilgai, the proportions of the ranch infested occasionally would drop to 0.6, 0.6 and 0.2, respectively. Differences in proportions of the ranch infested from year to year were due to primarily to differences in winter weather conditions, whereas infestation differences among tick habitat types were due primarily to habitat use preferences of hosts.

Conclusions

Infestations in nilgai augment SCFT refugia enabled by WTD and promote pest persistence across the landscape and cattle parasitism. Our study documented the utility of enhanced biosurveillance using simulation tools to mitigate risk and enhance operations of area-wide tick management programmes like the CFTEP through integrated tactics for SCFT suppression.
Molluscicidal and parasiticidal activities of Eryngium triquetrum essential oil on Schistosoma mansoni and its intermediate snail host Biomphalaria glabrata, a double impact
Authors: de Carvalho Augusto Ronaldo , Merad Nadjiya , Rognon Anne , Gourbal Benjamin , Bertrand Cédric , Djabou Nassim , Duval David
Published: September 2020

Background

Freshwater snails are the intermediate hosts of a large variety of trematode flukes such as Schistosoma mansoni responsible for one of the most important parasitic diseases caused by helminths, affecting 67 million people worldwide. Recently, the WHO Global Vector Control Response 2017–2030 (GVCR) programme reinforced its message for safer molluscicides as part of required strategies to strengthen vector control worldwide. Here, we present the essential oil from Eryngium triquetrum as a powerful product with molluscicide and parasiticide effect against S. mansoni and the snail intermediate host Biomphalaria glabrata.

Methods

In the present study, we describe using several experimental approaches, the chemical composition of E. triquetrum essential oil extract and its biological effects against the snail B. glabrata and its parasite S. mansoni. Vector and the free-swimming larval stages of the parasite were exposed to different oil concentrations to determine the lethal concentration required to produce a mortality of 50% (LC50) and 90% (LC90). In addition, toxic activity of this essential oil was analyzed against embryos of B. glabrata snails by monitoring egg hatching and snail development. Also, short-time exposure to sublethal molluscicide concentrations on S. mansoni miracidia was performed to test a potential effect on parasite infectivity on snails. Mortality of miracidia and cercariae of S. mansoni is complete for 5, 1 and 0.5 ppm of oil extract after 1 and 4 h exposure.

Results

The major chemical component found in E. triquetrum oil determined by GC-FID and GC/MS analyses is an aliphatic polyacetylene molecule, the falcarinol with 86.9–93.1% of the total composition. The LC50 and LC90 values for uninfected snails were 0.61 and 1.02 ppm respectively for 24 h exposure. At 0.5 ppm, the essential oil was two times more toxic to parasitized snails with a mortality rate of 88.8 ± 4.8%. Moderate embryonic lethal effects were observed at the concentration of 1 ppm. Severe surface damage in miracidia was observed with a general loss of cilia that probably cause their immobility. Miracidia exposed 30 min to low concentration of plant extract (0.1 ppm) were less infective with 3.3% of prevalence compare to untreated with a prevalence of 44%.

Conclusions

Essential oil extracted from E. triquetrum and falcarinol must be considered as a promising product for the development of new interventions for schistosomiasis control and could proceed to be tested on Phase II according to the WHO requirements.
The social construction of the social epigenome and the larger biological context
Authors: Deichmann Ute
Published: September 2020

Epigenetics researchers in developmental, cell, and molecular biology greatly diverge in their understanding and definitions of epigenetics. In contrast, social epigeneticists, e.g., sociologists, scholars of STS, and behavioural scientists, share a focus and definition of epigenetics that is environmentally caused and trans-generationally inherited. This article demonstrates that this emphasis on the environment and on so-called Lamarckian inheritance, in addition to other factors, reflects an interdisciplinary power struggle with genetics, in which epigenetics appears to grant the social sciences a higher epistemic status. Social scientists’ understanding of epigenetics, thus, appears in part to be socially constructed, i.e., the result of extra-scientific factors, such as social processes and the self-interest of the discipline. This article argues that social epigeneticists make far-reaching claims by selecting elements from research labelled epigenetics in biology while ignoring widely confirmed scientific facts in genetics and cell biology, such as the dependence of epigenetic marks on DNA sequence-specific events, or the lack of evidence for the lasting influence of the environment on epigenetic marks or the epigenome. Moreover, they treat as a given crucial questions that are far from resolved, such as what role, if any, DNA methylation plays in the complex biochemical system of regulating gene activity. The article also points out incorrect perceptions and media hypes among biological epigeneticists and calls attention to an apparent bias among scientific journals that prefer papers that promote transgenerational epigenetic inheritance over articles that critique it. The article concludes that while research labelled epigenetics contributes significantly to our knowledge about chromatin and the genome, it does not, as is often claimed, rehabilitate Lamarck or overthrow the fundamental biological principles of gene regulation, which are based on specific regulatory sequences of the genome.
Heterogeneous wireless IoT architecture for natural disaster monitorization
Authors: Porte Joaquim , Briones Alan , Maso Josep Maria , Pares Carlota , Zaballos Agustin , Pijoan Joan Lluis
Published: September 2020

A heterogeneous sensor network offers an extremely effective means of communicating with the international community, first responders, and humanitarian assistance agencies as long as affected populations have access to the Internet during disasters. When communication networks fail in an emergency situation, a challenge emerges when emergency services try to communicate with each other. In such situations, field data can be collected from nearby sensors deploying a wireless sensor network and a delay-tolerant network over the region to monitor. When data has to be sent to the operations center without any telecommunication infrastructure available, HF, satellite, and high-altitude platforms are the unique options, being HF with Near Vertical Incidence Skywave the most cost-effective and easy-to-install solution. Sensed data in disaster situations could serve a wide range of interests and needs (scientific, technical, and operational information for decision-makers). The proposed monitorization architecture addresses the communication with the public during emergencies using movable and deployable resource unit technologies for sensing, exchanging, and distributing information for humanitarian organizations. The challenge is to show how sensed data and information management contribute to a more effective and timely response to improve the quality of life of the affected populations. Our proposal was tested under real emergency conditions in Europe and Antarctica.
Solvability and algorithms of generalized nonlinear variational-like inequalities in reflexive Banach spaces
Authors: Gao Haiyan , Wang Lili , Zhao Liangshi
Published: September 2020

This paper deals with solvability and algorithms for a new class of generalized nonlinear variational-like inequalities in reflexive Banach spaces. By employing the Banach’s fixed point theorem, Schauder’s fixed point theorem, and FanKKM theorem, we obtain a sufficient condition which guarantees the existence of solutions for the generalized nonlinear variational-like inequality. We introduce also an auxiliary variational-like inequality and, by utilizing the minimax inequality, get the existence and uniqueness of solutions for the auxiliary variational-like inequality, which is used to suggest an iterative algorithm for solving the generalized nonlinear variational-like inequality. Under certain conditions, by means of the auxiliary principle technique, we both establish the existence and uniqueness of solutions for the generalized nonlinear variational-like inequality and discuss the convergence of iterative sequences generated by the iterative algorithm. Our results extend, improve, and unify several known results in the literature.
Nonlinear nonhomogeneous Dirichlet problems with singular and convection terms
Authors: Papageorgiou Nikolaos S. , Zhang Youpei
Published: September 2020

We consider a nonlinear Dirichlet problem driven by a general nonhomogeneous differential operator and with a reaction exhibiting the combined effects of a parametric singular term plus a Carathéodory perturbation $f(z,x,y)$
f
(
z
,
x
,
y
)
which is only locally defined in $x \in {\mathbb {R}} $
x
∈
R
. Using the frozen variable method, we prove the existence of a positive smooth solution, when the parameter is small.
A note on time-fractional Navier–Stokes equation and multi-Laplace transform decomposition method
Authors: Eltayeb Hassan , Bachar Imed , Abdalla Yahya T.
Published: September 2020

In this study, the double Laplace Adomian decomposition method and the triple Laplace Adomian decomposition method are employed to solve one- and two-dimensional time-fractional Navier–Stokes problems, respectively. In order to examine the applicability of these methods some examples are provided. The presented results confirm that the proposed methods are very effective in the search of exact and approximate solutions for the problems. Numerical simulation is used to sketch the exact and approximate solution.
Categorizing Malware via A Word2Vec-based Temporal Convolutional Network Scheme
Authors: Sun Jiankun , Luo Xiong , Gao Honghao , Wang Weiping , Gao Yang , Yang Xi
Published: September 2020

As edge computing paradigm achieves great popularity in recent years, there remain some technical challenges that must be addressed to guarantee smart device security in Internet of Things (IoT) environment. Generally, smart devices transmit individual data across the IoT for various purposes nowadays, and it will cause losses and impose a huge threat to users since malware may steal and damage these data. To improve malware detection performance on IoT smart devices, we conduct a malware categorization analysis based on the Kaggle competition of Microsoft Malware Classification Challenge (BIG 2015) dataset in this article. Practically speaking, motivated by temporal convolutional network (TCN) structure, we propose a malware categorization scheme mainly using Word2Vec pre-trained model. Considering that the popular one-hot encoding converts input names from malicious files to high-dimensional vectors since each name is represented as one dimension in one-hot vector space, more compact vectors with fewer dimensions are obtained through the use of Word2Vec pre-training strategy, and then it can lead to fewer parameters and stronger malware feature representation. Moreover, compared with long short-term memory (LSTM), TCN demonstrates better performance with longer effective memory and faster training speed in sequence modeling tasks. The experimental comparisons on this malware dataset reveal better categorization performance with less memory usage and training time. Especially, through the performance comparison between our scheme and the state-of-the-art Word2Vec-based LSTM approach, our scheme shows approximately 1.3% higher predicted accuracy than the latter on this malware categorization task. Additionally, it also demonstrates that our scheme reduces about 90 thousand parameters and more than 1 hour on the model training time in this comparison.
The scope and extent of literature that maps threats to species: a systematic map protocol
Authors: Ridley Francesca Anne , McGowan Philip JK , Mair Louise
Published: September 2020

Background

The rate of anthropogenic biodiversity loss far exceeds the background rate of species extinctions. Global targets for biodiversity acknowledge this, nevertheless progress towards targets has been poor. There is now a reasonable understanding of what human pressures threaten the survival of species. However, information on where these threats are impacting species is needed to coordinate conservation actions and threat abatement efforts. Herein, threats are defined as human-driven pressures specifically where they co-occur with, and threaten the survival of, native wild species. There is a large number of studies that map either distributions of threatened species or human-driven pressures alone. This makes it difficult to identify research that has investigated the spatial distribution of the threats themselves. Additionally, the high variability in approaches taken in these studies promotes a high risk of duplication and diversity among the findings. This variation, and the lack of studies directly mapping threats, limits the utility of threat mapping studies for conservation planning and informing policy. Therefore, a systematic consolidation of the literature is necessary to identify where knowledge is lacking, and where sufficient evidence exists for synthesis of the collective findings.

Methods

This protocol details the process for a systematic mapping exercise aiming to identify studies that map threats to species across the world. For a study to be included it should present spatially explicit data on both the occurrence of species and the human-driven pressures threatening them. A range of peer-reviewed and grey literature repositories will be searched in English for literature published 2000–2020, followed by one iteration of backward snowballing. A three-stage screening process will be implemented before data are extracted on geographic coverage, taxonomic extent, and threats investigated. Data on the threats studied will be categorised using the threat classification scheme used by the IUCN Red List to allow comparisons among studies and to identify unrepresented threats. The extracted data will be analysed and visualised to describe the extent of existing knowledge. The resulting database of studies, findings from descriptive analyses, and accompanying narrative synthesis, will be made publicly available.
Epidemiology and risk factors of rectal colonization of carbapenemase-producing Enterobacteriaceae among high-risk patients from ICU and HSCT wards in a university hospital
Authors: Yan Li , Sun Jide , Xu Xiuyu , Huang Shifeng
Published: September 2020

Background

Nosocomial carbapenemase-producing Enterobacterieceae (CPE) infections constitute a major global health concern and are associated with increased morbidity and mortality. Rectal colonization with CPE is a risk factor for bacterial translocation leading to subsequent endogenous CPE infections. This prospective observational study was aimed to investigate the prevalence and epidemiology of rectal colonization of CPE, the carbapenemase genotypes, and to identify the independent risk factors for the acquisition of CPE colonization in high-risk patients from ICU and HSCT wards in a university hospital in China.

Methods

In a prospective cohort study, 150 fecal samples from rectal swabs were consecutively obtained for inpatients from the intensive care unit (ICU) and hematopoietic stem cell transplantation (HSCT) wards from November 2018 to May 2019, and screening test for CPE was conducted by using prepared in-house trypsin soybean broth (TSB) selective media and MacConkey agar. Antimicrobial susceptibility was determined by the broth microdilution method and carbapenemase genes were characterized by both the GeneXpert Carba-R and PCR for blaKPC, blaNDM, blaIMP, blaVIM and blaOXA. Multi-locus sequence typing (MLST) was employed to characterize the genetic relationships among the carbapenemase-producing K. Pneumonia (CPKP) isolates. In order to further investigate the risk factors and clinical outcomes of CPE colonization, a prospective case-control study was also performed.

Results

Twenty-six suspected CPE strains, including 17 Klebsiella pneumoniae, 6 Escherichia coli, 1 Citrobacter freundii, 1 Enterobacter Kobe, and 1 Raoultella ornithinolytica, were identified in 25 non-duplicated rectal swab samples from 25 patients, with a carriage rate of 16.67% (25/150). Through GeneXpert Carba-R and subsequent PCR and sequencing, all the suspected CPE isolates were identified to be positive for the carbapenemase genes, of which 17 were blaKPC-carriers, and another 9 were blaNDM-producers. MLST designated all the CPKP isolates to be ST11 clone. Multivariate analysis indicated that urinary system diseases, operation of bronchoscopy, and combined use of antibiotics were independent risk factors for acquiring CPE colonization in high-risk patients from the ICU and HSCT wards.

Conclusions

This study revealed a high prevalence of rectal CPE colonization in high-risk patients from ICU and HSCT wards, and a predominant colonization of the KPC-producing K. pneumoniae clone ST11. Stricter infection control measures are urgently needed to limit the dissemination of CPE strains, especially in patients who were afflicted by urinary system diseases, have underwent bronchoscopy, and were previously exposed to combined antibiotic use.
Electrolytes supplementation can decrease the risk of nephrotoxicity in patients with solid tumors undergoing chemotherapy with cisplatin
Authors: Minzi Omary M. S. , Lyimo Tatu E. , Furia Francis F. , Marealle Alphonce I. , Kilonzi Manase , Bwire George M. , Malichewe Christina
Published: September 2020

Background

Cisplatin is an important drug in the treatment of various Cancers. However, this drug causes nephrotoxicity that is linked to electrolyte derangement. The aim of this study was to evaluate the effect of electrolyte supplementation in reducing kidney injury in patients receiving cisplatin-based regimen.

Methods

This was non-randomized interventional study conducted at Ocean Road Cancer Institute (ORCI) among patients with confirmed solid tumors. Patients who received cisplatin-based chemotherapy at a dose of ≥50 mg with intravenous normal saline supplemented with Magnesium, Calcium and Potassium (triple electrolyte supplementation) were compared with those who received cisplatin-based chemotherapy with normal saline alone. The patients were followed up for 4 weeks and serum creatinine was measured at every visit. Nephrotoxicity was defined as serum creatinine elevation > 1.5 times that at baseline.

Results

A total of 99 patients were recruited, whereby 49 patients (49.5%) received electrolyte supplementation (treatment group) and 50 patients (51.5%) did not receive electrolyte supplementation (control group). The incidence risk of nephrotoxicity was 20.41% (n = 10) in the treatment group and 54% (n = 27) in the control group. Patients in the control group were 2.6 times more likely to experience nephrotoxicity as compared to treatment group [Relative Risks (RR); 2.6, 95%CI; 1.5–4.9, P < 0.0001]. The most common malignancy was cervical cancer, n = 43 (87.8%) in treatment group and n = 45 (90.0%) in the control group (P = 0.590). The Kaplan-Meier analysis and the log-rank test revealed that electrolytes supplementation was associated with extended survival with less nephrotoxicity incidences [P = 0.0004; Hazard ratio (HR) 0.3149; 95% CI 0.165 to 0.6011].

Conclusions

Electrolytes supplementation decreases the risk of nephrotoxicity after chemotherapy with cisplatin. A randomized controlled trial with a larger sample size is recommended to evaluate the robustness of these findings.
Staffordshire Bull Terriers in the UK: their disorder predispositions and protections
Authors: Pegram Camilla , Wonham Katie , Brodbelt Dave C. , Church David B. , O’Neill Dan G.
Published: September 2020

Background

The Staffordshire Bull Terrier is a popular dog breed in the UK but there is limited reliable evidence on disorder predispositions and protections within the breed. Using anonymised veterinary clinical data from the VetCompass™ Programme, this study aimed to identify common disorders with predisposition and protection in the Staffordshire Bull Terrier. The study hypothesised that Staffordshire Bull Terriers would have higher odds of aggression compared with non-Staffordshire Bull Terriers.

Results

The clinical records of a random sample of dogs of all types were reviewed to extract the most definitive diagnoses for all disorders existing during 2016. A combined list from the 30 most common disorders in Staffordshire Bull Terriers and the 30 most common disorders in non-Staffordshire Bull Terriers was generated. Multivariable logistic regression was used to report the odds of each of these disorders in 1304 (5.8%) Staffordshire Bull Terriers compared with 21,029 (94.2%) non-Staffordshire Bull Terriers. After accounting for confounding, Staffordshire Bull Terriers had significantly increased odds of 4/36 (11.1%) disorders compared to non-Staffordshire Bull Terriers with highest odds for seizure disorder (OR 2.06; 95% CI 1.24 to 3.40;p = 0.005). Conversely, Staffordshire Bull Terriers had reduced odds of 5/36 (13.9%) disorders, with lowest odds for patellar luxation (OR 0.15; 95% CI 0.04 to 0.61;p = 0.008). There was no significant difference in the odds of aggression between Staffordshire Bull Terriers compared with non-Staffordshire Bull Terriers (OR 1.09; 95% CI 0.75 to 1.58;p = 0.644).

Conclusions

This study provides a reliable evidence base of breed-specific disorder predispositions and protections that can be used by breeders to optimise breeding decisions. The findings can assist prospective owners of Staffordshire Bull Terriers to make informed decisions when acquiring a dog. From the relative number of predispositions to protections identified, there is no evidence that Staffordshire Bull Terriers have higher overall health problems than non-Staffordshire Bull Terriers.
Biogeophysical and biogeochemical impacts of land-use change simulated by MIROC-ES2L
Authors: Ito Akihiko , Hajima Tomohiro
Published: September 2020

Land-use change is one of the focal processes in Earth system models because it has strong impacts on terrestrial biogeophysical and biogeochemical conditions. However, modeling land-use impacts is still challenging because of model complexity and uncertainty. This study examined the results of simulations of land-use change impacts by the Model for Interdisciplinary Research on Climate, Earth System version 2 for long-term simulations (MIROC-ES2L) conducted under the Land-Use Model Intercomparison Project protocol. In a historical experiment, the model reproduced biogeophysical impacts such as decreasing trends in land-surface net radiation and evapotranspiration by about 1970. Among biogeochemical impacts, the model captured the global decrease of vegetation and soil carbon stocks caused by extensive deforestation. By releasing ecosystem carbon stock to the atmosphere, land-use change shortened the mean residence time of terrestrial carbon and accelerated its turnover rate, especially in low latitudes. Future projections based on Shared Socioeconomic Pathways indicated substantial alteration of land conditions caused primarily by climatic change and secondarily by land-use change. Sensitivity experiments conducted by exchanging land-use data between different future projection baseline experiments showed that, at the global scale, the anticipated extent of land-use conversion would likely play a modest role in the future terrestrial radiation, water, and carbon budgets. Regional investigations revealed that future land use would exert a considerable influence on runoff and vegetation carbon stock. Further model refinement is required to improve its capability to analyze its complicated terrestrial linkages or nexus (e.g., food, bioenergy, and carbon sequestration) to climate-change impacts.
Towards integrated assessments of water risks in deglaciating mountain areas: water scarcity and GLOF risk in the Peruvian Andes
Authors: Motschmann Alina , Huggel Christian , Muñoz Randy , Thür Angela
Published: September 2020

Different water related risks such as lake outburst floods and water scarcity are typically assessed by separate methods and often by separate research communities. However, in a local context such as in mountain regions of the developing world different water risks are intertwined and shaped by multi-dimensional natural and socio-economic drivers. Progressing glacier melt and the associated growing number of lakes rises the threat of glacier lake outburst floods (GLOFs); at the same time declining melt water supply changes the hydrological regime, resulting in changing water availability, especially during dry seasons. Here, we address this challenge by integratively assessing water scarcity and GLOF risks and their interactions for two study sites in glacierized catchments in the Cordillera Blanca and Urubamba in the Peruvian Andes. We used hydrological modelling, GLOF flow path modelling, and interviews with local people and technical experts to assess the hazard and risks of water scarcity and GLOFs. We incorporate perspectives of people living in those areas in order to gain a more comprehensive view on risks. While metrics of flood and water scarcity hazards are difficult to compare, we found insightful results using a comparative analysis of elements at risk from different water related hazards with different probabilities of occurrence. Furthermore, our study shows that considering the diverse local perspectives on risks as well as the social, cultural, economic and political context is essential to more successful and sustainable disaster risk reduction, climate change adaptation and integrated water management.
The feasibility of an innovative GP-physiotherapist partnership to identify and manage chronic obstructive pulmonary disease (INTEGRATED): study protocol
Authors: Pagano Lisa , McKeough Zoe , Wootton Sally , Crone Stephen , Pallavicini Deborah , Chan Andrew S. L. , Mahadev Sriram , Zwar Nicholas , Dennis Sarah
Published: September 2020

Background

Chronic obstructive pulmonary disease (COPD) contributes significantly to mortality, hospitalisations and health care costs worldwide. There is evidence that the detection, accurate diagnosis and management of COPD are currently suboptimal in primary care. Physiotherapists are well-trained in cardiorespiratory management and chronic care but are currently underutilised in primary care. A cardiorespiratory physiotherapist working in partnership with general practitioners (GPs) has the potential to improve quality of care for people with COPD.

Methods

A prospective pilot study will test the feasibility of an integrated model of care between GPs and physiotherapists to improve the diagnosis and management of people with COPD in primary care. Four general practices will be selected to work in partnership with four physiotherapists from their local health district. Patients at risk of developing COPD or those with a current diagnosis of COPD will be invited to attend a baseline assessment with the physiotherapist, including pre- and post-bronchodilator spirometry to identify new cases of COPD or confirm a current diagnosis and stage of COPD. The intervention for those with COPD will involve the physiotherapist and GP working in partnership to develop and implement a care plan involving the following tailored to patient need: referral to pulmonary rehabilitation (PR), physical activity counselling, medication review, smoking cessation, review of inhaler technique and education. Process outcomes will include the number of people invited and reviewed at the practice, the proportion with a new diagnosis of COPD, the number of patients eligible and referred to PR and the number who attended PR. Patient outcomes will include changes in symptoms, physical activity levels, smoking status and self-reported exacerbations.

Discussion

If feasible, we will test the integration of physiotherapists within the primary care setting in a cluster randomised controlled trial. If the model improves health outcomes for the growing numbers of people with COPD, then it may provide a GP-physiotherapist model of care that could be tested for other chronic conditions.

Trial registration

ANZCTR, ACTRN12619001127190. Registered on 12 August 2019—retrospectively registered.
Design, rationale and analysis plan for the Stand Up for Health trial in contact centres: a stepped wedge feasibility study
Authors: Parker Richard A. , Manner Jillian , Sivaramakrishnan Divya , Baker Graham , Stoddart Andrew , Lloyd Scott , Jepson Ruth
Published: September 2020

Background

Contact centres are one of the most sedentary workplaces, with employees spending a very high proportion of their working day sitting down. About a quarter of contact centre staff regularly experience musculoskeletal health problems due to high levels of sedentary behaviour, including lower back pain. There have been no previous randomised studies specifically aiming to reduce sedentary behaviour in contact centre staff. To address this gap, the Stand Up for Health (SUH) study aims to test the feasibility and acceptability of a complex theory-based intervention to reduce sedentary behaviour in contact centres.

Methods

The Stand Up for Health study has a stepped wedge cluster randomised trial design, which is a pragmatic design whereby clusters (contact centres) are randomised to time points at which they will begin to receive the intervention. All contact centre staff have the opportunity to experience the intervention. To minimise the resource burden in this feasibility study, data collection is not continuous, but undertaken on a selective number of occasions, so the stepped wedge design is “incomplete”. Eleven contact centres in England and Scotland have been recruited, and the sample size is approximately 27 per centre (270 in total). The statistical analysis will predominantly focus on assessing feasibility, including the calculation of recruitment rates and rates of attrition. Exploratory analysis will be performed to compare objectively measured sedentary time in the workplace (measured using an activPAL™ device) between intervention and control conditions using a linear mixed effects regression model.

Discussion

To our knowledge, this is the first stepped wedge feasibility study conducted in call centres. The rationale and justification of our novel staircase stepped wedge design has been presented, and we hope that by presenting our study design and statistical analysis plan, it will contribute to the literature on stepped wedge trials, and in particular feasibility stepped wedge trials. The findings of the study will also help inform whether this is a suitable design for other settings where data collection is challenging.

Trial registration

The trial has been registered on the ISRCTN database: http://www.isrctn.com/ISRCTN11580369
Prevalence of HIV-associated esophageal candidiasis in sub-Saharan Africa: a systematic review and meta-analysis
Authors: Olum Ronald , Baluku Joseph Baruch , Okidi Ronald , Andia-Biraro Irene , Bongomin Felix
Published: September 2020

Background

Esophageal candidiasis (OC) is a common AIDS-defining opportunistic infection. Antiretroviral therapy (ART) reduces the occurrence of OC and other opportunistic infections among persons living with HIV (PLHIV). We sought to determine and compare the prevalence of OC in the ART and pre-ART era among PLHIV in sub-Saharan Africa (SSA).

Methods

We searched PubMed, Embase, Web of Science, and the African Journals Online databases to select studies in English and French reporting the prevalence of HIV-associated OC in SSA from January 1980 to June 2020. Reviews, single-case reports, and case series reporting < 10 patients were excluded. A random-effect cumulative meta-analysis was performed using STATA 16.0, and trend analysis performed using GraphPad Prism 8.0.

Results

Thirteen eligible studies from 9 SSA countries including a total of 113,272 patients were qualitatively synthesized, and 9 studies were included in the meta-analysis. Overall pooled prevalence of HIV-associated OC was 12% (95% confidence interval (CI): 8 to 15%, I2 = 98.61%, p <. 001). The prevalence was higher in the pre-ART era compared to the ART era, but not to statistical significance (34.1% vs. 8.7%, p = 0.095). In those diagnosed by endoscopy, the prevalence was higher compared to patients diagnosed by non-endoscopic approaches, but not to statistical significance (35.1% vs. 8.4%, p = .071). The prevalence of OC significantly decreased over the study period (24 to 16%, p < .025).

Conclusion

The prevalence of OC among PLHIV in the ART era in SSA is decreasing. However, OC remains a common problem. Active endoscopic surveillance of symptomatic patients and further empirical studies into the microbiology, optimal antifungal treatment, and impact of OC on quality of life of PLHIV in SSA are recommended.
Clinical situations for which 3D printing is considered an appropriate representation or extension of data contained in a medical imaging examination: adult cardiac conditions
Authors: Ali Arafat , Ballard David H. , Althobaity Waleed , Christensen Andy , Geritano Mariah , Ho Michelle , Liacouras Peter , Matsumoto Jane , Morris Jonathan , Ryan Justin , Shorti Rami , Wake Nicole , Rybicki Frank J. , Sheikh Adnan ,   on behalf of the RSNA 3D Printing Special Interest Group
Published: September 2020

Background

Medical 3D printing as a component of care for adults with cardiovascular diseases has expanded dramatically. A writing group composed of the Radiological Society of North America (RSNA) Special Interest Group on 3D Printing (SIG) provides appropriateness criteria for adult cardiac 3D printing indications.

Methods

A structured literature search was conducted to identify all relevant articles using 3D printing technology associated with a number of adult cardiac indications, physiologic, and pathologic processes. Each study was vetted by the authors and graded according to published guidelines.

Results

Evidence-based appropriateness guidelines are provided for the following areas in adult cardiac care; cardiac fundamentals, perioperative and intraoperative care, coronary disease and ischemic heart disease, complications of myocardial infarction, valve disease, cardiac arrhythmias, cardiac neoplasm, cardiac transplant and mechanical circulatory support, heart failure, preventative cardiology, cardiac and pericardial disease and cardiac trauma.

Conclusions

Adoption of common clinical standards regarding appropriate use, information and material management, and quality control are needed to ensure the greatest possible clinical benefit from 3D printing. This consensus guideline document, created by the members of the RSNA 3D printing Special Interest Group, will provide a reference for clinical standards of 3D printing for adult cardiac indications.
Diagnostic efficacy of gel infusion sonography in post-menopausal bleeding
Authors: Ahmed Shimaa Abdalla , Abo-Taleb Hisham
Published: September 2020

Background

Our purpose was to evaluate the diagnostic performance of two-dimensional transvaginal ultrasound (2D-TVUS) and gel infusion sonography (GIS) at offline analysis for endometrial characterization compared with real-time evaluation during scanning.

One hundred fifty women presented with PMB. At TVUS, endometrial thickness was ≥ 4 mm in 122 (81.3%) women and < 4 mm in 28 (18.72%). Among 122 women with endometrial thickness > 4 mm, GIS was successfully performed in 117 (95.9%). Examinations were stored as video clips for later evaluation (offline analysis) by two less experienced radiologists. Endometrial lesions were classified into four categories: no endometrial abnormality, hyperplasia, polyps, and cancer. Diagnostic efficiency of real-time and offline analysis for diagnosis of each category was calculated and compared, and inter-observer agreement for offline analysis was calculated.

Results

All patients underwent hysteroscopy and/or hysterectomy. Histopathological results confirmed no endometrial abnormality in (27.3%, 41/150), endometrial hyperplasia in (12.7%, 19/150), endometrial polyps in (17.3%, 26/150), and endometrial cancer in (42.7%, 64/150).

Overall diagnostic accuracy of real-time imaging was 89.7% (CI 84–91%)). The highest accuracy 92.7% (CI 88–98%) was seen in the diagnosis of cancer, and polyps 91.5% (CI 86–97%). The lowest accuracy 75% (CI 69–82%) was seen in hyperplasia.

Overall diagnostic accuracy of offline analysis was 81%, and it increased to 88% (CI 83–92%) after a restricted analysis of good quality clips. The highest accuracy 90.7% (CI 83–95%) was seen in the diagnosis of polyps, and cancer 90.4% (CI 83–96%). The lowest accuracy 71% (CI 69–75%) was seen in hyperplasia.

At offline analysis, the inter-observer agreement was substantial k = 0.77 (CI 71–84) in the evaluation of four endometrial categories after the exclusion of bad quality videos. It was excellent in exclusion of endometrial abnormalities k = 0.85 (0.78–0.90), substantial in the diagnosis of polyps k = 0.71 (0.69–0.88), cancer k = 0.61 (0.61–0.77), and moderate in the diagnosis of hyperplasia k = 0.41 (0.30–0.41).

Conclusion

Offline 2D analysis with a good image quality has comparable accuracy to a real-time evaluation during scanning in the diagnosis of endometrial lesions. It can increase the accuracy of sonography in ruling out endometrial abnormalities and diagnose non-hyperplastic endometrial pathologies. High NPV and substantial reproducibility can make it an efficient initial screening method in a post-menopausal bleeding.
Red knots (Calidris canutus islandica) manage body mass with dieting and activity
Authors: Mathot Kimberley J. , Kok Eva M. A. , van den Hout Piet , Dekinga Anne , Piersma Theunis
Published: September 2020

Mass regulation is birds is well documented. For example, birds can increase body mass in response to lower availability and/or predictability of food and decrease body mass in response to increased predation danger. Birds also demonstrate an ability to maintain body mass across a range of food qualities. Although the adaptive significance of mass regulation has received a great deal of theoretical and empirical attention, the mechanisms by which birds achieve this have not. Several non-exclusive mechanisms could facilitate mass regulation in birds. Birds could regulate body mass by adjusting food intake (dieting), activity, baseline energetic requirements (basal metabolic rate, or BMR), mitochondrial efficiency, or assimilation efficiency. Here, we present the results of two experiments in captive red knots (Calidris canutus islandica) that assess three of these proposed mechanisms: dieting, activity, and up/down-regulation of metabolic rate. In the first experiment, knots were exposed to cues of predation risk that led them to exhibit presumably adaptive mass loss. In the second experiment, knots maintained constant body mass despite being fed on alternating high- and low-quality diets. In both experiments, regulation of body mass was achieved through a combination of changes in food intake and activity. Both experiments also provide some evidence for a role of metabolic adjustments. Taken together, these two experiments demonstrate that fine-scale management of body mass in knots is achieved through multiple mechanisms acting simultaneously.
More than noise: Context-dependant luminance contrast discrimination in a coral reef fish (Rhinecanthus aculeatus)
Authors: van den Berg Cedric P. , Hollenkamp Michelle , Mitchell Laurie J. , Watson Erin J. , Green Naomi F. , Marshall N. Justin , Cheney Karen L.
Published: September 2020

Achromatic (luminance) vision is used by animals to perceive motion, pattern, space and texture. Luminance contrast sensitivity thresholds are often poorly characterised for individual species and are applied across a diverse range of perceptual contexts using over-simplified assumptions of an animal's visual system. Such thresholds are often estimated using the Receptor Noise Limited model (RNL) using quantum catch values and estimated noise levels of photoreceptors. However, the suitability of the RNL model to describe luminance contrast perception remains poorly tested.

Here, we investigated context-dependent luminance discrimination using triggerfish (Rhinecanthus aculeatus) presented with large achromatic stimuli (spots) against uniform achromatic backgrounds of varying absolute and relative contrasts. ‘Dark’ and ‘bright’ spots were presented against relatively dark and bright backgrounds. We found significant differences in luminance discrimination thresholds across treatments. When measured using Michelson contrast, thresholds for bright spots on a bright background were significantly higher than for other scenarios, and the lowest threshold was found when dark spots were presented on dark backgrounds. Thresholds expressed in Weber contrast revealed increased contrast sensitivity for stimuli darker than their backgrounds, which is consistent with the literature. The RNL model was unable to estimate threshold scaling across scenarios as predicted by the Weber-Fechner law, highlighting limitations in the current use of the RNL model to quantify luminance contrast perception. Our study confirms that luminance contrast discrimination thresholds are context-dependent and should therefore be interpreted with caution.