bluuebunny/crossref_metadata_2025 huggingface dataset:
La amazonificación de la logística: Comercio electrónico, trabajo y explotación en la última milla
Authors: Alimahomed Wilson Jake
Published: October 2024

Este artículo ofrece, en primer lugar, una visión general de algunos de los cambios estructurales generales en la industria de la logística global resultantes de las estrategias de gestión de la cadena de suministro de Amazon, con especial atención a las condiciones que dieron lugar a la logística de última milla. Mi argumento es que las prácticas de gestión de la cadena de suministro de Amazon han dado lugar a un cambio de paradigma en la logística global y la gestión de la cadena de suministro. Describo estos cambios estructurales como la “amazonificación de la logística”. A continuación, presento un estudio de caso sobre cómo esta amazonificación de la logística ha afectado a los trabajadores de reparto de última milla de Amazon en la región de Los Ángeles. El sector de la entrega de última milla del sur de california ofrece una visión de las formas en que Amazon ha perjudicado negativamente a los trabajadores de la logística. Por último, en las conclusiones, se recogen algunas claves para conseguir cambios en las condiciones laborales en el sector.
Logística, trabajo y almacenes: el lado oscuro de la digitalización
Authors: Santos Ortega Juan Antonio , Muñoz Rodríguez David
Published: October 2024

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Duque, Ignacio y Gómez Benito, Cristobal (eds.) 2020 En torno a Alfonso Ortí: la sociología crítica como sociohistoria. Madrid: UNED.
Authors: Barbeta Viñas Marc
Published: October 2024

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La inclusividad en la etapa de secundaria del sistema educativo español
Authors: Lodeiro Sánchez Josefina , Urraco Solanilla Mariano
Published: October 2024

El objetivo del presente artículo es analizar la inclusividad del sistema educativo español en la etapa de secundaria. Para ello se ha realizado un trabajo de revisión bibliográfica sobre los distintos términos empleados en torno a estas cuestiones, se ha analizado lo que dicen las leyes educativas españolas y se ha comparado con los datos sobre la situación actual del sistema educativo en España. A partir de dicho trabajo de revisión se concluye que la realidad del sistema educativo está muy lejos del ideal inclusivo reconocido en la legislación y que la situación es todavía más complicada para los alumnos que llegan a la etapa de educación secundaria.
La posición de las mujeres en el Parlamento valenciano tras el cambio político del año 2015: la nueva política valenciana y la perspectiva de género
Authors: López Blat Elena
Published: October 2024

La dimensión política en la representación de las mujeres constituye un fenómeno explicativo de otras dimensiones de la desigualdad de género. Esta investigación trata de profundizar sobre los factores que sustentan el techo de cristal que padecen las mujeres en la política valenciana. Para ello, se realiza un análisis a través de información extraída de diputadas valencianas de tres partidos políticos: Compromís, Podemos y Ciudadanos. Estos partidos son categorizados como “la nueva política” por sus demandas sobre regeneración política, transparencia e igualdad. En esta investigación se analiza si el cambio político que abanderan estos partidos incluye la perspectiva de género. Se constata que la importancia de la representación de la mujer para los partidos de la nueva política depende de su ideológica política, tal y como sucede con los partidos tradicionales. Pero el factor de la experiencia y tradición de partidos resulta ser un elemento clave. Sin la combinación de ambos la presencia de las mujeres se ve notablemente perjudicada. Todo ello sin olvidar la importancia de los mecanismos internos, puesto que la presencia no es igual al poder es necesario ir más allá de la formalidad de las cuotas.
La “marca personal” en la academia los procesos de subjetivación en las condiciones de trabajo del profesorado universitario
Authors: Medina Calvo Ángela
Published: October 2024

En nuestro tiempo uno de los discursos más populares del gerencialismo es el personal branding. La literatura de la marca personal moviliza un nuevo modelo de empleabilidad adscrito a racionalidades neoliberales y emprendedoras. En este trabajo nos aproximamos a las prácticas académicas afines a estas racionalidades. El régimen corporativo y digital de la universidad contemporánea insta a las y los académicos a promocionar(se) como una marca bibliográfica personal. No obstante, perviven conductas académicas de resistencia a esta rúbrica de la excelencia bibliométrica.
De la flexibilidad laboral a la jornada interminable. Teletrabajar en tiempos de confinamiento
Authors: García Sainz Cristina , Barreiro Rodríguez María , Faz Pozuelo Samira
Published: October 2024

La modalidad de teletrabajo es el exponente actual más destacado del modelo de producción flexible. Su desarrollo provoca cambios, tanto en la propia organización de los tiempos de trabajo como en los ritmos domésticos. Durante el confinamiento, obligado por la Covid-19, el trabajo desde casa ha aumentado considerablemente, lo que ha tenido una especial repercusión para quienes tienen responsabilidades educativas y de cuidado de menores en edad escolar y preescolar. La implantación del teletrabajo es mayor en grupos profesionales bien situados en la escala laboral, aunque difiere según ocupación, vínculo contractual, antigüedad, edad, género y situación familiar, entre otras variables. Durante los meses críticos de la pandemia el teletrabajo ha visibilizado las transferencias de tiempo y de recursos que se producen entre la esfera laboral y la doméstica. En este artículo se analizan los efectos de estas interconexiones sobre los tiempos de trabajo.
Introducción al monográfico. Sociología del tiempo: escenarios en la Covid-19
Authors: García Sainz Cristina , Callejo Javier , Gabaldón Estevan Daniel
Published: October 2024

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contribució de stuart hall (1932-2014) a la sociologia de la cultura crítica i d’interpretació sociocultural
Authors: Mulet Trobat Bartomeu
Published: October 2024

Cal contextualitzar les qüestions plantejades en el marc de la teoria de la cultura, les ciències socials en general i la sociologia de la cultura en especial, per comprendre i afavorir l’anàlisi de la realitat social en termes relacionals, tant pel que fa a les aportacions de sociològiques de la cultura de Stuart Hall com a sociòleg de la cultura en el context dels Estudis Culturals. Es tracta d’analitzar l’aportació de Hall en les característiques actuals de la sociologia de la cultura amb la seva funció de crítica i sociocultural, per tal d’entendre els complexos fenòmens de desigualtat que es generen a la societat del context de la modernitat tardana. Tot tenint present l’explicació del paper de Stuart Hall, amb l’acompanyament sociològic d’altres autors com R. Williams, R. Hoggart, E. P. Thompson, P. Willis, L. Grossberg, A. Ariño, H. Giroux, A. Grimson i influenciada per A. Gramsci, M. Foucault o J. Butler, amb la crítica des de l’Economia Política e M. Ferguson i P. Golding, J. W. Carey i així poder aconseguir una interpretació sociològica fonamentada. Es pretén explicar a Hall com un dels impulsors de la sociologia de la cultura, mitjançant la interpretació de qüestions de desigualtat ètnica, gènere, multiculturalisme, els efectes sobre la societat dels mitjans de comunicació de masses-cultura popular, identitat i/o identificació cultural, amb esperit crític basat en una concepció teòrica del materialisme cultural, que separa el reduccionisme econòmic i en el context de la teoria de la resistència.
Normalizar el comportamiento de los alumnos a través del yoga en Francia
Authors: Carmen Garcia Marie
Published: October 2024

Las prácticas yóguicas han tenido un gran éxito en Francia, y en la mayoría de los países industrializados durante los últimos treinta años, como parte de un movimiento más general de psicologización de las relaciones sociales y de desarrollo de prácticas de superación personal. En este artículo, analizamos cómo estas prácticas son movilizadas por los profesores con un objetivo doble y a priori contradictorio. En primer lugar, a nivel colectivo, mantener la disciplina y la normalización de los comportamientos necesarios en el marco de la forma de socialización escolar. En segundo lugar, a nivel individual, formar alumnos autónomos y responsables en congruencia con las normas liberales dominantes. Los análisis realizados, a partir de entrevistas con profesoras que despliegan tales prácticas contradictorias, conducen a varias propuestas programáticas para el análisis de la enseñanza del yoga en el contexto francés.
Participación del alumnado LGTBI+ de la Universitat de València en la actividad físico-deportiva: una aproximación desde la perspectiva del trabajo social
Authors: Ruiz-Gil Tania
Published: October 2024

Si bien el ámbito del Trabajo Social (TS) actúa en áreas de intervención muy diversas, aún hoy en día es escasa la literatura existente en esta disciplina que contemple el deporte como herramienta de intervención e inclusión. Esto es aún más visible en el entorno universitario, en el que hay pocas evidencias en cuanto al bienestar de las personas LGTBI+ y la posible contribución del TS para el bienestar de este colectivo. Si además se incluye la participación y las experiencias de las personas LGTBI+ en las actividades físico-deportivas (AFD), que tienden a ser espacios masculinizados y heteronormativos, la literatura en cuanto al TS es aún menor. El objetivo principal de esta investigación es conocer la participación y las experiencias del estudiantado LGTBI+ de la Universitat de València en las AFD para explorar las posibilidades de intervención desde el TS. Para llevar a cabo este objetivo se realizó una encuesta a 88 estudiantes LGTBI+ de esta universidad. Los principales resultados obtenidos constatan que un 56,8% del alumnado LGTBI+ practica AFD fuera del entorno universitario y un 23,9% en el entorno universitario; el 46,2% responde que le ha influido haber observado actitudes LGTBIfóbicas en su práctica en la AFD fuera del entorno universitario y un 60% en el entorno universitario; un 48,9% participaría en equipos mixtos en el caso de que se ofertasen; el 71,6% de las personas encuestadas está a favor de incluir a profesionales del Trabajo Social en organizaciones deportivas para ayudar a mejorar el bienestar psicosocial de las personas; asimismo, un 81,8% menciona la necesidad de aprobar un protocolo de inclusión del colectivo LGTBI+ en el ámbito deportivo de la UV. Los resultados muestran la necesidad de aumentar la investigación para conocer cómo la intervención desde el TS puede contribuir en el bienestar del estudiantado universitario LGTBI+ en la AFD. Es recomendable incorporar profesionales del TS en los equipos multidisciplinares deportivos para incorporar una mirada social a la hora de crear medidas y políticas que favorezcan los colectivos vulnerados.
Anàlisi de la productivitat científica de la revista Arxius de Ciències Socials (2011- 2021): autories, gènere, col·laboració i tendències d’investigació
Authors: Che Tórtola Clara
Published: October 2024

S’analitza la investigació difosa en la revista Arxius de Ciències Socials en el període (2011-2021). La revista ha publicat 240 treballs distribuïts en 21 exemplars, en els quals els hòmens han signat un 58,62% dels articles per un 41,38% de les dones. Pel que fa a la participació institucional, s’han identificat un total de 166 institucions diferents, prop de la meitat d’elles (44,58%) internacionals, podent-se destacar les institucions franceses, argentines i brasileres. L’anàlisi de la col·laboració científica mostra una creixent tendència a la investigació col·laborativa. Respecte a la llengua de publicació, s’observa un clar domini del castellà (78,3%), seguida del valencià i l’anglès. Finalment, les tendències d’investigació es focalitzen majoritàriament al voltant de la sociologia del treball, l’educació, el medi ambient i les migracions. La comparativa entre el període de la revista de 1997 a 2010 i l’actual, mostra, en trets generals, com la revista Arxius de Ciències Socials esdevé més activa, col·laborativa, global i femenina.
Arxius de Ciències Socials: Unas notas sobre su nacimiento y contexto
Authors: Ariño Villarroya Antonio
Published: October 2024

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Mills, Manuscripts and Monastic Archives: The Phillipps Charters of Mont Saint-Michel
Authors: Allen Richard , Pohl Benjamin
Published: October 2024

This article examines three medieval charters of the Norman abbey of Mont
Saint-Michel, today preserved among the collections of the John Rylands Research
Institute and Library. Rare survivors of the destruction of the abbey’s
archives in 1944, these charters previously formed part of the enormous private
library assembled by Sir Thomas Phillipps (1792–1872), antiquarian and
bibliophile. They are here studied in detail for the first time, showcasing them
not just for what they can tell us about the property to which they relate and
the celebrated abbey to which it once belonged, but, more importantly, for what
they reveal about the structure and organisation of the lost institutional
archive of which they formed a part in the Middle Ages. This article also
contextualises these charters within the wider Phillipps collection, exploring
questions associated with the antiquarian practice of preserving and presenting
medieval documents, a subject which has only recently begun to receive the
scholarly attention it deserves.
An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis
Authors: Lehle Jake D , Lin Yu-Huey , Gomez Amanda , Chavez Laura , McCarrey John R
Published: October 2024

Endocrine disrupting chemicals (EDCs) such as bisphenol S (BPS) are xenobiotic compounds that can disrupt endocrine signaling due to steric similarities to endogenous hormones. EDCs have been shown to induce disruptions in normal epigenetic programming (epimutations) and differentially expressed genes (DEGs) that predispose disease states. Most interestingly, the prevalence of epimutations following exposure to many EDCs persists over multiple generations. Many studies have described direct and prolonged effects of EDC exposure in animal models, but many questions remain about molecular mechanisms by which EDC-induced epimutations are introduced or subsequently propagated, whether there are cell type-specific susceptibilities to the same EDC, and whether this correlates with differential expression of relevant hormone receptors. We exposed cultured pluripotent (iPS), somatic (Sertoli and granulosa), and primordial germ cell-like (PGCLC) cells to BPS and found that differential incidences of BPS-induced epimutations and DEGs correlated with differential expression of relevant hormone receptors inducing epimutations near relevant hormone response elements in somatic and pluripotent, but not germ cell types. Most interestingly, we found that when iPS cells were exposed to BPS and then induced to differentiate into PGCLCs, the prevalence of epimutations and DEGs was largely retained, however, >90% of the specific epimutations and DEGs were replaced by novel epimutations and DEGs. These results suggest a unique mechanism by which an EDC-induced epimutated state may be propagated transgenerationally.
Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging
Authors: Tsai Yi-Ting , Seymen Nogayhan , Thompson I Richard , Zou Xinchen , Mumtaz Warisha , Gerlevik Sila , Mufti Ghulam J , Karimi Mohammad M
Published: October 2024

Retrotransposons (RTEs) have been postulated to reactivate with age and contribute to aging through activated innate immune response and inflammation. Here, we analyzed the relationship between RTE expression and aging using published transcriptomic and methylomic datasets of human blood. Despite no observed correlation between RTE activity and chronological age, the expression of most RTE classes and families except short interspersed nuclear elements (SINEs) correlated with biological age-associated gene signature scores. Strikingly, we found that the expression of SINEs was linked to upregulated DNA repair pathways in multiple cohorts. We also observed DNA hypomethylation with aging and significant increase in RTE expression level in hypomethylated RTEs except for SINEs. Additionally, our single-cell transcriptomic analysis suggested a role for plasma cells in aging mediated by RTEs. Altogether, our multi-omics analysis of large human cohorts highlights the role of RTEs in biological aging and suggests possible mechanisms and cell populations for future investigations.
Feasibility and acceptability pilot study of an online weight loss program in rural, underserved communities
Authors: Oliveira Ashleigh , Alfouzan Nouf , Yu Jin , Yahya Asma , Lammy Kayla , Wright Mary Liz , Reinhold Diane , Peterson Lisa , Brewer Ashley , Liechty Janet , Nakamura Manabu T.
Published: October 2024

Background

The purpose of this intervention was to investigate the feasibility, acceptability, and preliminary effectiveness of an online weight loss program, EMPOWER, in rural, underserved communities.

Methods

Adults with a body mass index (BMI) ≥ 25 kg/m2 living in rural counties were recruited through collaboration with University of Illinois Extension. The intervention lasted 1 year including online educations sessions, nutrition and lifestyle coaching, and diet and weight monitoring via a novel web application, MealPlot. Feasibility was measured by enrollment attainment, participant retention, online education session completion, and completion of anthropometric and dietary measures. Acceptability was measured by survey using Likert scales of satisfaction for all program components. Anthropometric measurements, 24-h dietary records, and food frequency questionnaires (FFQs) were measures of program efficacy. Additionally, two interviews were collected for program feedback.

Results

Enrollment of 16 participants was attained, however due to higher than anticipated dropout (retention 62.5%, N = 10) at 3-months, 62.5% of the education sessions were completed and 75.0% of anthropometric and dietary measures. The average satisfaction rating for the comprehensive program was 4.2/5 with lowest satisfaction being the MealPlot web application 2.7/5 (N = 11). On average a clinically significant (≥5% baseline weight) weight loss of 6.2 ± 6.0% body weight or 5.7 ± 5.3 kg and improvements to protein and fiber intake at 12 months (N = 10) were observed.

Conclusions

A novel online weight loss program showed adequate to strong feasibility and acceptability and preliminary results indicating efficacy among a pilot sample of rural residents. Future studies are required to investigate means of improving retention and reducing the burden on program collaborators.
Fatores para a construção de uma relação de confiança no agronegócio: o caso de pecuaristas e indústrias frigoríficas
Authors: Jesus Daniel Andrade de , Araujo Reginaldo Roque de , Vidigal Filho Ademir Luiz , Dias Ademilson de Assis , Vidigal Lucélia Largura do Vale , Souza Valdinei Leones de , Loose Cleberson Eller , Souza Naiara Meireles de
Published: October 2024

Este trabalho buscou estudar os fatores que contribuem para a relação de confiança nas negociações entre pecuaristas de carne bovina e indústrias frigoríficas. De modo complementar, visando analisar como cada fator pode contribuir para a relação de confiança, foi realizado um levantamento junto a pecuaristas de quatorze cidades e oito indústrias frigoríficas pertencentes a região imediata de Cacoal - Rondônia, região pertencente a Amazônia Legal. Para realização deste estudo, uma pesquisa bibliográfica foi realizada e depois, como técnica de coleta de dados, foi aplicado um questionário estruturado com pecuaristas e indústrias frigoríficas. Os principais resultados obtidos foram que os principais fatores da relação de confiança para os pecuaristas e frigoríficos são bem-estar animal, transporte e manejo e transparência nas negociações, exceto pesagem na balança que foi considerado somente para os pecuaristas. Esse estudo pode ser utilizado como base para outros estudos envolvendo pecuaristas e indústrias frigoríficas de outras regiões do Brasil.
Management of Vicharchika (Eczema) by Multi-model Ayurveda Intervention: A Case Report
Authors: Kapatkar Shruti Prakash , Deshmukh Sourabh , Thakre Trupti , Rathi Renu
Published: October 2024

Ayurveda, the ancient system of medicine, comprehensively categorises skin disorders under the term “Kushtharoga”, encompassing a wide spectrum of dermatological conditions. This classification is further elucidated into “Mahakushtha” and “Kshudra Kushtha”, representing major and minor skin diseases, respectively. Major skin ailments include psoriasis, eczema, leprosy, and vitiligo, while minor conditions encompass common issues such as acne and dermatitis. Vicharchika, a term in Ayurveda associated with symptoms akin to eczema, poses a challenge in contemporary medical practices, where treatment options are often limited to antihistamines and topical steroids. The present case report describes the successful Ayurvedic management of a patient presenting with complaints of itching, discharge and erythematous skin lesions on the foot. The 36-year-old female patient was diagnosed with Vicharchika (eczema) and received treatments such as Bahir Parimarjana Chikitsa (External treatment) and Shaman Chikitsa (alleviating treatment) in place of Shodhana (Purification therapy) due to Alpadoshaavastha (immature body tissues), which resulted in significant improvement. The present case underscores the potential efficacy of Ayurvedic interventions, emphasising the importance of personalised treatment strategies in addressing dermatological conditions.
Evaluation of Anti-inflammatory and Antioxidant Properties of Persea Americana and Syzygium Aromaticum-based Herbal Mouthwash Formulation: An In-vitro Study
Authors: Dharini S , Pandiar Deepak , Rajeshkumar S , Krishnan Reshma Poothakulath
Published: October 2024

Introduction: Medicinal plants and their substances are used as adjunctive therapies for a range of acute and chronic inflammatory diseases. Syzygium aromaticum and Persea americana, in particular, have demonstrated beneficial effects, including anti-inflammatory and antioxidant properties, in the management of inflammation. Although the extracts from these plants have been assessed in research, the possibility of combining them to synthesise a mouthwash and evaluate its effectiveness has not yet been investigated. Aim: To evaluate the combined anti-inflammatory and antioxidant properties of a mouthwash formulation based on the extensively nutritious avocado fruit (Persea americana) and clove (Syzygium aromaticum). Materials and Methods: This in-vitro investigation was carried out in the Oral Pathology and Microbiology Department at Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India, between December 2021 and July 2022. A mouthwash was formulated with extracts from clove and avocado fruit, and its anti-inflammatory and antioxidant properties were evaluated using Bovine Serum Albumin (BSA) denaturation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays, respectively. Microsoft Excel was utilised for data collection, and Statistical Package for the Social Sciences (SPSS) version 23.0 with independent t-tests was used for statistical analysis. A p-value of 0.05 was considered statistically significant. Results: The anti-inflammatory activity of the prepared mouthwash based on P. americana and Syzygium aromaticum at a concentration of 50 μL (86.62% inhibition) was comparable to that of the standard drug (diclofenac sodium) (84.82% inhibition); however, its antioxidant properties were significantly lower. Conclusion: The mouthwash synthesised from the edible part of P. americana in conjunction with Syzygium aromaticum exhibited superior anti-inflammatory properties, with the highest activity observed at a concentration of 50 μL. Therefore, the prepared formulation could be used for managing minor inflammatory conditions.
Ayurvedic Treatment as an Adjunct to Oral Hypoglycaemics in Diabetic Wound Management: A Case Report
Authors: Patil Sunil B , Singh Arvind Omhari , Shaikh Aiman , Kulkarni Satyajit Pandurang , Parwe Shweta
Published: October 2024

The widespread occurrence of Type 2 Diabetes Mellitus (T2DM) is a significant public health issue in India. Diabetes severely impedes the wound healing process. Delayed wound healing in diabetes is caused by a decrease in nitric oxide generation, the presence of Advanced Glycation End products (AGEs), and impaired epithelial cell motility. In this case, a 38-year-old diabetic male presented seeking Ayurvedic treatment for a wound on his right lower limb, which resulted from a prick injury sustained 10 days earlier. He also had varicose veins in both legs and had been living with diabetes for five years. His medical history included slow wound healing. The condition was diagnosed as “Dushtvrana” associated with “Prameha” and was treated with Ayurvedic medicines in addition to oral hypoglycaemics. The Ayurvedic treatment included Panchavalkala Kwatha Vranadhavan, followed by the local application of Yashtimadhu Ghrita every third day, along with the oral administration of Nishadhatri Yoga (5 g) twice daily. Additionally, he was prescribed a daily evening dose of 500 mg metformin tablets for 25 days. There was no pain or inflammation observed, and the wound fully healed. This case demonstrates the effectiveness of Ayurvedic treatment-Panchavalkala Kwatha Vranadhavan, Yashtimadhu Ghrita for local application, and oral Nishadhatri Yoga-as an adjunct to the oral hypoglycaemic drug metformin in treating diabetic wounds
Evaluation of Entospletinib as a Novel Therapeutic Strategy Targeting Spleen Tyrosine Kinase in Retinoblastoma Treatment: An In-vitro Study
Authors: Krishnakumar Sneha , Anusha D , Karthika K , Kavitha R
Published: October 2024

Introduction: Retinoblastoma (RB) is the most common paediatric intraocular malignancy. The Spleen Tyrosine Kinase (SYK) acts as a proto-oncogene crucial for RB cell survival and is absent in the normal retina, making it a valuable therapeutic target. Aim: Entospletinib, a selective oral SYK inhibitor currently in phase 2 trials for chronic lymphocytic leukaemia, was evaluated for its activity on the RB cell line Y-79. Materials and Methods: The effects of Entospletinib on cell proliferation and death of the human RB Y79 cells were assessed by MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay, phase contrast microscopy and AO/EtBr dual labeling. The Annexin-V kit was used to quantify the cell mortality following treatment using flow cytometry. The mRNA levels of caspase-3, BAX, BCL-2, SYK, p53, TNF-and NF-κB were measured using RT-PCR to better understand the mechanism of action of this drug. Western blot was used to further validate the data. Results: Entospletinib treatment led to a time- and dosedependent reduction in cell viability, with significant cytotoxicity observed at an IC50 of 61.3 µM/ml. Annexin V/Propidium Iodide (PI) staining demonstrated a dose-dependent increase in apoptosis. The treatment upregulated mRNA levels of Caspase-3, Bax, and p53 while downregulating SYK, TNF-α, and Bcl-2. RT-PCR and Western blot analyses confirmed a dose-dependent decrease in NF-κB/p65 expression. Conclusion: The study findings suggest that Entospletinib inhibits cell proliferation and induces apoptosis in RB cells by downregulating SYK/TNF-α/NF-κB/p65, highlighting its potential as a promising therapeutic candidate for RB.
Prevalence and Variations in the Mandibular Canal assessed using Cone Beam Computed Tomography: A Retrospective Observational Study
Authors: Paul Samadrita , Pachipulusu Balaji , Chandra Poornima , Govindraju Poornima
Published: October 2024

Introduction: Variations in the Mandibular Canal (MC) can be categorised based on shape (oval, round, or pear-shaped) and may include various accessory canals, such as bifid, trifid, or temporal crest canals. These variations are clinically significant because if, they are overlooked, they can lead to various complications. While both 2 Dimensional (2D) and 3D imaging modalities can evaluate these variations, Cone Beam Computed Tomography (CBCT) offers superior resolution, reduced radiation exposure, and a comprehensive 3D view. Aim: To analyse the prevalence and variations of the MC, as well as its diameter and length among the Indian population. Materials and Methods: A retrospective observational study was conducted in the Department of Oral Medicine and Radiology at Rajarajeswari Dental College and Hospital, Ramohalli Cross, Mysuru Road, Bengaluru, Karnataka, India over a period of six months from October 2023 to April 2024. Total of 190 CBCT images were randomly collected from the CBCT archives, spanning ages 16 to 75 years. The length and diameter of the MC were measured using CBCT tools. The prevalence of variations in the MC was determined according to the classification provided for bifid and trifid canals. The Chisquare test was employed to compare the anatomical variations of the MC based on age and gender, while an independent Student’s t-test was used to compare the mean length and mean diameter based on age groups and gender. Results: The mean age of the study population was 37.96±14.63 years. Among the 190 images, 105 (55.3%) belonged to males and 85 (44.7%) belonged to females. The frequency of bifid canals was comparatively higher than that of trifid and temporal crest canals, with incidence rates of 14.7%, 3.7%, and 5.3%, respectively, showing no significant association with age or gender. Females exhibited a bilateral reduction in vertical diameter (mean difference of 0.37 mm compared to males at 0.40 mm). The mean length of the MC was notably longer on the left-side among males (mean MC length on the left-side: 69.36 mm compared to the right-side: 67.64 mm). Conclusion: The present study highlights the importance of understanding variations in the MC. CBCT imaging enhances the comprehension of MC anatomy, facilitating accurate diagnostic and treatment strategies in dentistry and maxillofacial surgery
Impact of Painful Diabetic Peripheral Neuropathy on the Quality of Life of Patients in Goa, India: A Cross-sectional Study
Authors: Fernandes Jorida , Dudhani Sharmila , Mukkannavar Prashant , Vaigankar Sejal
Published: October 2024

Introduction: The state of Goa has the highest prevalence of diabetes and prediabetes in India. Pain because of abnormalities in the somatosensory system due to diabetes is referred to as Painful Diabetic Peripheral Neuropathy (PDPN). A common complication associated with PDPN is poor Quality of Life (QoL), which can lead to lifelong disability. Aim: To estimate the prevalence of PDPN and its impact on QoL in patients in Goa, India. Materials and Methods: In this cross-sectional observational study, 320 participants were screened at Goa Medical College, Bambolim, Goa, India, from August 2021 to August 2022, and 288 were diagnosed with Diabetic Peripheral Neuropathy (DPN). Among those 288 individuals, 91 reported experiencing PDPN, as assessed using the Douleur Neuropathique 4 (DN-4) questionnaire. The investigator interviewed participants aged 18 to 75 years, of all genders, who were diagnosed with either Type 1 or Type 2 diabetes. Baseline characteristics, including age, weight, height, Body Mass Index (BMI), duration of diabetes, and results from the lateralisation test using the graded motor imagery app, were recorded. Participants were assessed using the Neuropathy Symptom Score, and only those who scored at least 1 were included, indicating the presence of DPN. These participants then completed the DN-4 questionnaire; those scoring 3 or more were diagnosed with PDPN. Subsequently, QoL was assessed using the RAND QoL questionnaire {RAND Short Form Survey (SF-36)}. Demographic and clinical characteristics were presented as mean±Standard Deviation (SD). Comparisons between patients with PDPN and those without PDPN were made using an Independent t-test. The normality of continuous variables was tested using the Kolmogorov-Smirnov test. All analyses were carried out using IBM Statistical Package for the Social Sciences (SPSS) (version 28.0). Results: The prevalence of PDPN was found to be 31.6%, with significant impairments in the physical functioning, social functioning, and pain domains (p-value <0.001). Conclusion: The prevalence of PDPN was found to be 31.6%. Significant impairments in various QoL domains were noted in participants with PDPN.
FACTORS SHAPING CORPORATE SOCIAL DISCLOSURE PRACTICES: EVIDENCE FROM THE SAUDI ARABIAN CONTEXT
Authors: CHARCHAFA Ilyes , KIMOUCHE Bilal
Published: October 2024

This research investigates factors influencing corporate social disclosure (CSD) within the context of Saudi Arabia. Specifically, it examines how corporate governance attributes and company characteristics impact the extent of CSD. The study utilizes data from 435 firm-year observations spanning 87 companies listed on Saudi Exchange (Tadawul) during 2015-2019. CSD levels are gauged using an unweighted disclosure index derived from the Global Reporting Initiative (GRI) framework. The results reveal a negative effect of board size on CSD, suggesting that smaller boards may encourage more comprehensive disclosures. Conversely, the effects of board independence and audit committee independence are insignificant. In line with theoretical predictions, larger, profitable, manufacturing companies, as well as those involved in international operations, tend to disclose more social information. The current research contributes to the literature, addressing conflicting findings on the effects of board characteristics and profitability, and exploring the underexplored roles of audit committee independence and internationalization.
CHARACTERISTICS AND RECRUITMENT STRATEGY OF GENERATION Z IN INDUSTRY TRADES: AN EXAMPLE OF THE WELDER PROFESSION
Authors: SANOGO Farouck Oumar , SİPAHİ DONGUL Esra
Published: October 2024

Generations Y and Z may show different tendencies in the job market and prefer different management approaches. Generation Z can enter the language of economic actors as anxious or carefree. The emergence of new professions, more liberal and adapting to these young people, pushes them away from industrial professions. This study aims to propose a change in recruitment methods to professionals in the industrial sector, primarily in the welding profession, or, if necessary, to human resources departments. The analyzes carried out on the questionnaires filled out by 152 volunteer participants, most of whom are university and graduate students, were analyzed with the IBM SPSS Statistics 26 FixPack 1 program and studied at a 95% confidence level. In the analysis, the frequency and percentage values of the categorical variables were determined. The relationship between university, gender and age and categorical variables was analyzed by Chi-square test. Study results; the importance of digital resources in the job and internship search process, the priority of company reputation and working environment in job selection, the effect of personal passion on educational preferences and the low interest in the welding profession, In addition, factors such as the importance of the job and its guarantee are also decisive in the choice of profession. This study is thought that the study will represent an analytical support for companies and SMEs that enable them to take the necessary measures to counter today's harsh reality.
Scientific Approaches to the Characterization, Processing, Production, and Marketing of Novel Herbal Plants
Authors: Malathi G. , Gomadhi G. , Mangammal P. , Kiruba M. , Krishnaveni S. Anandha , Kumar P. , Devi T. Sivasankari , Vidhya D. , Senthilkumar T.
Published: October 2024

The integration of novel herbal plants into modern therapeutic practices necessitates a thorough understanding of their characterization, processing, production, and marketing. This study explores scientific approaches to each of these critical stages, highlighting the importance of advanced analytical techniques for accurate characterization of bioactive compounds. Methods such as high-performance liquid chromatography (HPLC) and mass spectrometry are employed to identify and quantify key phytochemicals, ensuring quality control and efficacy. Processing techniques are examined to optimize extraction methods and formulation processes, aiming to preserve the therapeutic potential of herbal products while enhancing their bioavailability. The study emphasizes the need for sustainable production systems and rigorous quality control measures to maintain product consistency and safety. Good manufacturing practices (GMP) and adherence to regulatory guidelines are essential for ensuring the integrity of herbal materials, effective marketing strategies are discussed, focusing on evidence-based communication and consumer education to promote the benefits of novel herbal plants. The study underscores the role of scientific research in informing marketing practices and fostering consumer trust, a multidisciplinary approach combining scientific research with practical application is crucial for advancing herbal medicine. The findings underscore the need for continued research and collaboration among scientists, industry professionals, and policymakers to drive innovation and enhance the therapeutic potential of novel herbal plants.
Diagnostic and Surgico-therapeutic Management of Perineal Tumour in Dogs
Authors: Kaushik Vishal , Jain Reshma , Parihar Atul S. , Shrivastava Niddhi , Shukla B. P. , Gaur Megha
Published: October 2024

The benign perianal tumour form comprises more than 80% and is third most common tumour in male dogs. The present study was planned to record the cases of perineal tumour, their diagnosis and management. Their age, sex, breed, size of tumour and clinical history were recorded. Clinical, physical, radiographic and ultrasonographic examination of affected dogs were also done accordingly.
In uncastrated male dogs first castration was done 2-4 weeks before excision of tumour via open prescrotal castration method. Corrective surgery was performed for tumour excision in 9 dogs under general anaesthesia as per the standard technique. Two dogs diagnosed with venereal granuloma, were treated by using the  chemotherapeutic protocol.
During the study of perineal affection, 11 cases of perineal tumour were recorded in intact male dogs. Indian Spitz breed was most commonly affected followed by other breeds. Varying size of perineal tumours were recorded along with anorexia, faecal and urinary incontinence. Radiographic examination and  Ultrasonography were also done to determine the nature and extent of perineal swelling for accurate removable of growth without any complications.
In the haematological studies, there was significant decrease in neutrophil and increase in lymphocyte and monocyte count. Biochemical parameters indicated a non-significant decline. In cytological and histopathological analysis, it was confirmed that 5 dogs had perianal adenoma, 2 had perianal epithelioma, 2 had venereal granuloma, 1 had anal gland adenoma and 1 had adenocarcinoma. Perianal adenoma could be managed successfully by surgical excision with castration. Venereal granuloma growth in perineal region could be corrected successfully with chemotherapeutic protocol with good outcome.
Light Pollution and Its Effects on Human Health and the Environment: A Review
Authors: Hassan Najmaldin Ezaldin
Published: October 2024

Light pollution, the presence of excessive or misdirected artificial light, has become a growing concern due to its adverse impacts on both human health and the environment. This review explores the multifaceted issue of light pollution, starting with an overview of its various forms skyglow, glare, and light trespass—and how urbanization and industrialization have exacerbated these problems. The review examines key sources of light pollution, including streetlights, commercial signage, and residential lighting, and discusses their contributions to environmental degradation and health issues. The environmental impacts of light pollution are significant, affecting nocturnal wildlife by disrupting natural behaviors and ecological interactions, and altering plant growth and reproduction. The review details how artificial light interferes with natural cycles, including circadian rhythms, and the resultant effects on animal and plant life. From a human health perspective, the review highlights how light pollution disrupts circadian rhythms, leading to sleep disorders, increased stress, and mood disorders. It addresses the psychological and cognitive effects of disrupted sleep, including impaired attention, memory, and executive function. Additionally, the review outlines the links between chronic light exposure and increased risks of obesity, cardiovascular diseases, and metabolic disorders. Mitigation strategies, including improved outdoor lighting design and public awareness initiatives, are discussed as essential measures to address light pollution. By providing a comprehensive analysis of the sources, effects, and potential solutions, this review underscores the urgent need for effective interventions to protect both human health and the natural environment from the detrimental effects of light pollution.
Constraints Encountered by ATMA Beneficiaries for Disseminating Agricultural Knowledge in Chhatarpur District of Madhya Pradesh, India
Authors: Gupta Rohit Kumar , Saryam Manoher , Mandloi Rishikesh
Published: October 2024

A group of important stakeholders in the district's agricultural development for sustainable agriculture is known as ATMA. It serves as a hub for the decentralization of the public agricultural technology System's regular operations and the integration of research and extension activities. It is a registered society responsible for technology dissemination at the district level. This study was carried out in Chhatarpur district of Madhya Pradesh state. Ex-post-facto research design was followed in the study. For the present study 210 respondents were selected for present study. The study found that constraints encountered by ATMA beneficiaries lack of communication facilities was identified as major constraint reported by highest percentage of respondents (87.14%) and ranked first, followed by poor contact between farmers, agriculture officers & scientist with opinion of 83.33 per cent respondents and ranked in second, inadequate and untimely supply of desired inputs reported by 71.90 per cent respondents. Among the suggestion given by ATMA beneficiaries to overcome the constraints in participation of different ATMA activities presented in Table 2 revealed that the majority of beneficiaries (89.05%) were suggested to organize programme in right time and given it first rank. The suggestion on “demonstration should be conduct on farmer’s field” was identified by 80.48 per cent beneficiaries and got it second rank. The 65.71 per cent beneficiaries were suggested to “information must be provided on proper time” and given it third rank. we suggested that latest information regarding agricultural technology should be provided during training programme, interested rural youth and ATMA beneficifies should be selected at as Kisan Mitra and more need focused trainings should be arranged.
District Level Child and Women Nutritional Status in Andhra Pradesh State of India-Food Based Intervention Options for Improvement and Associated Issues
Authors: Prasanna P.A.Lakshmi , B.Sreedevi  , Reddy J.Rajashekar
Published: October 2024

In this study, an attempt has been made to analyse changes in district level child and women nutritional status in Andhra Pradesh, using two latest National Family Health Survey (NFHS) data pertaining to years 2015-16 and 2019-20.  Computing standardized undernutrition, over nutrition and anaemia index, priority districts under the three nutritional issues were identified.  Regression analysis indicated that per capita income was able to explain only very low percentage of variation in various nutritional indicators across the districts. Then progress in ongoing efforts towards improving nutritional status through distribution of fortified rice, and development of bio-fortified varieties are documented and associated issues were discussed. Need for co-ordination between different food-based programs for nutritional security, building specific value chains targeting specific consumer category, enforcement of food safety and monitoring mechanisms for proper compliance and implementation of the programs, were identified for accelerating improvement in nutritional status in the state.
Screening and Genotypic Characterization of Lactic Cultures Isolated from Fermented Idli Batter
Authors: Angadi Viswanatha , C Ram Kumar , L Malashree, , R Prabha
Published: October 2024

The present study was conducted during 2021-22 at Dairy Science College, Bangalore, India to study the microflora present in fermented control idli batter and batter added with paneer whey and characterize them to use as solid-state fermentation cultures for idli batter fermentation. Eighteen isolates were screened for their phenotypic characteristics after enumeration of microflora in ingredients and fermented batter. The paneer whey was used at 70% of the water used as value addition and by-product utilization for enhancing the nutritional quality of idli. Further, these lactic cultures were screened for their activity for acid production and DMC in the whey-based medium. Titratable acidity ranged from 0.42 to 0.70% lactic acid with a highest of 0.70 for Lb1 and lowest of 0.42 for Leu6 and W4 isolates. DMC was highest at 8.01 log10 cells/ml for E1 isolate and lowest at 7.41 log10 cells/ml for W4 with a range from 7.41 to 8.01 log10 cells/ml. The isolates with code numbers Lb1, Lb2, Leu2, and E1 showed higher titratable acidity and DMC. DNA extracted from the selected four isolates was subjected to PCR and PCR products were sequenced. Based on the results obtained species of isolates were identified as Leuconostoc sp. strain Leu2, Enterococcus sp. strain E1, Lactobacillus brevis strain Lb1, and Lactobacillus casei strain Lb2. The nucleotide sequences of 16S rRNA were submitted to GenBank of NCBI and obtained accession numbers as MW 386845.1, MW386871.1, MW480882.1, and MW485119.1 respectively. These isolates were further used as solid-state fermentation cultures for idli batter fermentation.