bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatially ordered recruitment of fast muscles in accordance with movement strengths in larval zebrafish
Authors: Shimizu Sayaka , Katayama Taisei , Nishiumi Nozomi , Tanimoto Masashi , Kimura Yukiko , Higashijima Shin-ichi
Published: January 2025

In vertebrates, skeletal muscle comprises fast and slow fibers. Slow and fast muscle cells in fish are spatially segregated; slow muscle cells are located only in a superficial region, and comprise a small fraction of the total muscle cell mass. Slow muscles support low-speed, low-force movements, while fast muscles are responsible for high-speed, high-force movements. However, speed and strength of movement are not binary states, but rather fall on a continuum. This raises the question of whether any recruitment patterns exist within fast muscles, which constitute the majority of muscle cell mass. In the present study, we investigated activation patterns of trunk fast muscles during movements of varying speeds and strengths using larval zebrafish. We employed two complementary methods: calcium imaging and electrophysiology. The results obtained from both methods supported the conclusion that there are spatially-ordered recruitment patterns in fast muscle cells. During weaker/slower movements, only the lateral portion of fast muscle cells is recruited. As the speed or strength of the movements increases, more fast muscle cells are recruited in a spatially-ordered manner, progressively from lateral to medial. We also conducted anatomical studies to examine muscle fiber size. The results of those experiments indicated that muscle fiber size increases systematically from lateral to medial. Therefore, the spatially ordered recruitment of fast muscle fibers, progressing from lateral to medial, correlates with an increase in fiber size. These findings provide significant insights into the organization and function of fast muscles in larval zebrafish, illustrating how spatial recruitment and fiber size interact to optimize movement performance.
Uprooting, removing and relocating populations: The role and significance of internal displacement in the syrian regime’s integrated military–political war strategy
Authors: Bakkour Samer , Sahtout Rama
Published: January 2025

International actors have only relatively recently recognized that internal displacement is a strategy, as well as a consequence, of violent conflict, and the subject accordingly continues to give rise to a host of misinterpretations and misunderstandings, including the tendency to view it as a protection challenge, which persists despite the fact that state actors, as the supposed protectors, are also invariably the main perpetrators of displacement. This article seeks to explore and establish the ‘place’ of internal displacement in the Syrian Regime’s political and military strategy in Assad’s ongoing war on the Syrian people. It draws on an emerging literature on displacement, along with a range of reports on the Regime’s internal displacement activities in the Civil War, to propose that it needs to be engaged and understood as a rational strategy that is being applied to alter existing demographic realities. After zooming in to focus on strategic displacement in particular, it seeks to demonstrate that displacement should not just be understood in terms of its military significance, but also as a mechanism that the Regime uses to reconfigure and rearrange existing political and social realities.
Latent tuberculosis prevalence in healthcare workers in Laos: a cross-sectional study
Authors: Duangmixay Sypaseuth , Virachith Siriphone , Hübschen Judith M. , Siphanthong Phitsada , Suthepmany Sakhone , Sayasone Somphou , Black Antony P.
Published: January 2025

Background

Individuals with latent tuberculosis infection (LTBI) have a high risk of active infection, morbidity and mortality. Healthcare workers are a group who have increased risk of infection and onward transmission to their patients and other susceptible individuals; however, LTBI is often undiagnosed, and individuals are asymptomatic. Interferon gamma release assays (IGRA) can detect evidence of TB infection in otherwise asymptomatic individuals and are a good indication of LTBI. Laos, a resource limited country in southeast Asia, has limited data on TB prevalence in the general population or in healthcare workers. This study aimed to estimate the prevalence of LTBI in Lao healthcare workers in Vientiane Capital.

Methods

Healthcare workers from high-risk departments from 3 central hospitals in Laos were included (n = 196) and venous blood was tested by IGRA. A questionnaire was administered to determine their knowledge, attitude and practice towards TB and LTBI.

Results

10.2% of the participants were positive by IGRA, none of whom were previously aware of their TB status. The questionnaire revealed that knowledge and awareness of TB and LTBI were low.

Discussion

A significant proportion of healthcare workers in this study had evidence of LTBI infection. These individuals were unaware of their TB status and we suggest that testing and treatment, as well as prevention strategies, should be routinely administered in Lao hospitals.
Health security—Why is ‘public health’ not enough?
Authors: Akhavein Delaram , Sheel Meru , Abimbola Seye
Published: January 2025

There is a growing tendency in global discourse to describe a health issue as a security issue. But why is this health security language and framing necessary during times of crisis? Why is the term “health security” used when perhaps simply saying “public health” would do? As reference to ‘health security’ grows in contemporary discourse, research, advocacy, and policymaking, its prominence is perhaps most consequential in public health. Existing power dynamics in global health are produced and maintained through political processes. Securitisation of health, which facilitates urgent and exceptional measures in response to an event, is a politically charged process with the tendency to further marginalise already marginalised individuals, groups, and nations. By exploring the ethical and practical consequences of a powerful actor’s move to securitise health, the essay highlights the importance of considering the perspectives and well-being of marginalised individuals, groups and nations who may be impacted by the move. The essay challenges the assumption that securitising health or framing health as a security issue necessarily leads to good outcomes. It highlights the historical roots and explores the contemporary implications of “health security”, and invites critically informed discourse on its use within global health.
A modified technique for radial artery access: how interventional radiologists can optimise the cardiologists’ technique to suite their procedures
Authors: Aldin Zaid , Weaver Josephine , Khan Maha , Sadik Tara , Manolas Viktor , Tsampoukas Georgios , Khatri Tariq , Rebek Marius , Gharib Ali , Diss James
Published: January 2025

Background

This is a single-centre prospective observational study examining radial access in 62 Prostatic Artery Embolisation (PAE) procedures. Evaluation of left radial artery diameter using high frequency ultrasound before and after administration of sublingual glycerl trinitrate (GTN). Pre-procedure questionnaires calculating symptom severity score compared with post-procedure.

Results

Sublingual GTN resulted in a statistically significant increase in radial artery diameter (p < .00001). There was a statistically significant reduction in both average International Prostate Symptom Score (IPSS) and Quality of Life (QoL) from pre-procedure to post-PAE. The radial sheath was successfully inserted in 100% of cases. Crossover rate to femoral access was low (4%). Radial artery access had a low complication rate (2%). Radial artery variant anatomy was reasonably common (7%).

Conclusions

Sublingual GTN significantly increase radial artery diameter. PAE from radial access is associated with a symptomatic improvement at 2-month follow-up.
Current status of bicompartmental arthroplasty
Authors: Gao Yingjian , Yue Bing , Xin Weiwei
Published: January 2025

Background

Bicompartmental arthroplasty (BCA) serves as a less invasive alternative to total knee arthroplasty. This review aims to present the current status of BCA.

Body

Recent literature on BCA was reviewed and synthesized from the perspectives of function, radiological assessment, patient satisfaction, survival rate, patellar tracking, satisfaction survey, and revision rate.

Conclusion

BCA is beneficial for patients with bicompartmental arthritis and those suffering from deterioration in other compartments after unicompartmental knee arthroplasty (UKA). Compared to total knee arthroplasty, BCA reduces trauma, accelerates recovery, and improves sports ability. While BCA is evolving towards a more exciting future, more clinical studies are warranted to exploit its potential and validate its efficacy, eventually improving outcomes and patient satisfaction.
Permeation kinetics of nano-emulsified tarragon essential oil in fermented pickled cucumbers by FTIR, antioxidant capacity potentiometry, and antimicrobial properties
Authors: Nikkhah Mahdi , Hematian Sourki Abdollah , Ghani Askar
Published: January 2025

The permeation kinetics of nano-emulsified tarragon essential oil (TEO) into fermented pickled cucumber texture was measured by Fourier transform infrared spectrometry (FT-IR) and antioxidant capacity potentiometry. The objective was to evaluate how nano-emulsion affect the sensory, antioxidant, physicochemical, and microbial flora characteristics of the pickled cucumbers. Oil-in-water nano-emulsions (100, 200, 400 and 800 mg L−1) were prepared by ultrasonic waves and were added to the brine/vinegar and cucumber mixture. The analysis of chemical compounds by gas chromatography showed that the main components of TEO were methyl chavicol, Z-β-ocimene, E-β-ocimene, limonene, and methyl eugenol. The average particle size of nano-emulsions was ranging from 19.03 to 218.6 nm. The sensory evaluation of pickled cucumber containing nano-emulsified TEO showed that higher TEO concentrations increased the sensory characteristics significantly in the pickled cucumbers, such as their color, aroma, taste, mouthfeel, texture crispness, and overall acceptance. The microbial test proved the inhibitory effect of TEO on Penicillium expansum and Aspergillus flavus species. According to the results of FTIR, the nano-emulsified TEO penetrated well into the pickled cucumber texture. The antioxidant capacity of the pickled cucumbers revealed that by increasing the concentration of TEO, the antioxidant capacity of the pickled cucumber texture increased significantly (p < 0.05). Using nano-emulsified TEO can be a good replacement for dried vegetables in producing fermented pickled cucumbers.

Graphical Abstract
Analysis of genetic and pathologic association between diabetes mellitus and cervical cancer
Authors: Gupta Prakhar , Gupta Aankury , Khanam Bushra
Published: January 2025

Background

Cervical cancer is the fourth most common cancer among women globally and second most common in India. As per WHO, almost 90% of new cases and deaths worldwide occurred in low- to middle-income countries in 2020. More than 95% of cervical cancers are associated with chronic Human papilloma virus infection (HPV). While high-income countries benefit from vaccination and screening programmes, such facilities are often unavailable in low- and middle-income regions. Diabetes is also rising in prevalence in these regions. It is associated with a higher risk of various cancers, including cervical, endometrial, stomach, breast, and pancreas cancers. Diabetic cancer patients are also observed to have poorer survival outcomes. This study aims to compare the prevalence of cervical pathologies in diabetic and non-diabetic females of reproductive age and investigate potential genetic overlaps.

Methods

We analysed pap smear records from diabetic and non-diabetic females and examined genetic data using GWAS to explore associations between diabetes mellitus, HPV infection, and cervical cancer.

Results

In total, 3325 pathologic sample records were analysed and 2411 genes were identified and explored for overlap between diabetes and cervical pathologies from available GWAS data. It was noted that diabetes was associated with higher occurrence of cervical pathologies like vaginitis (OR 1.42), cervicitis (OR 13.89), HPV infection (OR 2.38) and malignant changes (OR 1.29). On analysing available genetic data for diabetes mellitus (types 1 and 2), chronic HPV infection, CIN and cervical cancer, certain genes showed positive association with both spectrums (diabetes mellitus and cervical pathologies) like COLL11A2P1 (beta 0.06), INS-IGF2 (OR 1.63), TTC7B (OR 2.05) and SILC1 (OR 2.12).

Conclusion

The pathologic and genetic association may help in understanding the connection between the two diseases in a better way. It may also help in guiding targeted approach and screening programmes in regions with higher preponderance towards upregulation of such genes.
Effect of preoperative right ventricular dysfunction and dilatation on survival after left ventricular surgical restoration
Authors: Elsayed Abdelhameed , Alawami Murtadha H. , Elnaggar Ismail M. , Mohamed Tamer N. , Kiddo Musab , Shalaby Mostafa A. , Alotaibi Khaled A. , Arafat Amr A.
Published: January 2025

Background

This study investigated the impact of preoperative right ventricular (RV) dysfunction and dilatation on survival outcomes following left ventricular surgical restoration (LVSR) in patients with ischemic cardiomyopathy. A retrospective analysis was conducted on 137 patients who underwent LVSR between 2009 and 2021.

Results

The results indicated that hospital mortality was significantly associated with older age [OR, 1.10; P = 0.01], higher EuroSCORE II [OR, 1.08, P = 0.03], recent myocardial infarction [OR, 4.24, P = 0.02], lower creatinine clearance [OR, 0.97, P = 0.02], and left ventricle longitudinal [OR, 0.95, P < 0.01] and transverse diameter [OR, 0.95; P < 0.01]. Although RV dysfunction alone did not significantly impact survival (log-rank P = 0.48), a trend toward lower survival rates was observed in patients with concurrent RV dilatation and dysfunction (log-rank P = 0.08). Long-term follow-up revealed no significant reduction in RV diameter after surgery. Multivariable analysis revealed that EuroSCORE II [HR, 1.05; P < 0.01], atrial fibrillation [HR, 3.34; P < 0.01], left ventricular longitudinal diameter [HR, 0.97; P < 0.01], and right ventricular basal diameter [HR, 1.06, P < 0.01] were independent predictors of long-term mortality.

Conclusions

This study underscores the importance of comprehensive preoperative evaluation of RV dimensions and function in predicting outcomes after LVSR, emphasizing the need for tailored management strategies for patients with RV abnormalities.
The role of artificial intelligence in pandemic responses: from epidemiological modeling to vaccine development
Authors: Gawande Mayur Suresh , Zade Nikita , Kumar Praveen , Gundewar Swapnil , Weerarathna Induni Nayodhara , Verma Prateek
Published: January 2025

Integrating Artificial Intelligence (AI) across numerous disciplines has transformed the worldwide landscape of pandemic response. This review investigates the multidimensional role of AI in the pandemic, which arises as a global health crisis, and its role in preparedness and responses, ranging from enhanced epidemiological modelling to the acceleration of vaccine development. The confluence of AI technologies has guided us in a new era of data-driven decision-making, revolutionizing our ability to anticipate, mitigate, and treat infectious illnesses. The review begins by discussing the impact of a pandemic on emerging countries worldwide, elaborating on the critical significance of AI in epidemiological modelling, bringing data-driven decision-making, and enabling forecasting, mitigation and response to the pandemic. In epidemiology, AI-driven epidemiological models like SIR (Susceptible-Infectious-Recovered) and SIS (Susceptible-Infectious-Susceptible) are applied to predict the spread of disease, preventing outbreaks and optimising vaccine distribution. The review also demonstrates how Machine Learning (ML) algorithms and predictive analytics improve our knowledge of disease propagation patterns. The collaborative aspect of AI in vaccine discovery and clinical trials of various vaccines is emphasised, focusing on constructing AI-powered surveillance networks. Conclusively, the review presents a comprehensive assessment of how AI impacts epidemiological modelling, builds AI-enabled dynamic models by collaborating ML and Deep Learning (DL) techniques, and develops and implements vaccines and clinical trials. The review also focuses on screening, forecasting, contact tracing and monitoring the virus-causing pandemic. It advocates for sustained research, real-world implications, ethical application and strategic integration of AI technologies to strengthen our collective ability to face and alleviate the effects of global health issues.
Pacific Peoples' Experiences of Cancer and Its Treatment in Aotearoa New Zealand Through Talanoa: A Qualitative Study of Samoan and Tongan Participants
Authors: Perelini Olivia M. , Nosa Vili H. , Wilson Michelle K. , Lawrence Nicola J. , McNeill Rob B. , Wilson Sheridan
Published: January 2025

PURPOSE

In Aotearoa New Zealand, there are inequitable outcomes for Pacific peoples who experience higher rates of preventable cancers and poorer survival compared with other ethnicities. The aim of this study was to explore Pacific peoples lived experience of cancer and its treatment in the Auckland setting.

METHODS

Data were collected through semistructured interviews (talanoa) with Pacific patients under the Auckland Regional Cancer and Blood Service. A general inductive approach was used to analyze the data. Ethical approval was granted by the Auckland Health Research Ethics Committee (reference number AH24086).

RESULTS

Thirteen participants of Samoan and Tongan ethnicity were interviewed. Participants had a range of tumor diagnoses and were receiving curative and noncurative treatments. Five key themes were identified, giving insight into beliefs around cancer, struggles faced by patients, and potential areas of priority. These include (1) cancer means death, (2) holistic and collective approach to support, (3) communication and trust, (4) cost in accessing cancer care and treatment, and (5) Pacific representation.

CONCLUSION

This study sheds light on both positive and negative experiences of Pacific peoples living with cancer in Aotearoa New Zealand. It highlights gaps in the current model of oncology care for this population, which are multilevel and therefore require a multifaceted approach. It calls for priority toward reducing barriers to access of care and creating a more culturally safe pathway.
Quantum kernel as an indicator of secure classical message coded in a quantum string
Authors: Elkhouly E. S. , Abd-Rabbou M. Y. , Ali S. I. , Metwally N.
Published: January 2025

In this study, the quantum kernel is utilized as an indicator of the security of encoded information within classical strings. The impact of the Hadamard gate on the behavior of single, control, and all quantum strings is analyzed. To illustrate this concept, two distinct classical strings are examined. Our findings reveal that the position of the string significantly influences the level of security of the encoded information, depending on whether it acts as a control or target string. Furthermore, the quantum string's capacity remains almost stable when it functions as a target string during the entanglement process, whereas an unstable behavior is observed when it serves as the control string.
Development and Psychometric Testing of the Perceived Environment and Muscle-Strengthening Exercise Questionnaire in Adults
Authors: Brown Elise C. , Zeigler-Hill Virgil , Rajaee Mozhgon , Drignei Dorin , Reznar Melissa M. , Regensteiner Judith G. , DeSandre Mackenzie , Gada Sagar , Bistayi Alex , Selou Angelina , Palmer Tylor
Published: January 2025

Introduction

Despite the health benefits of performing regular muscle-strengthening exercise (MSE), prevalence rates of meeting the public health guidelines for MSE remain low. Understanding barriers to MSE participation may aid in health promotion efforts and intervention design. Thus, the purpose of this study was to develop and test the psychometric properties of the Perceived Environment and Muscle Strengthening Exercise Questionnaire (PEMSE-Q), a tool that measures environmental effects on MSE.

Methods

The questionnaire included 77 items measuring physical environment, home MSE equipment accessibility, and MSE social support. This study was conducted in a combined national sample of two independent groups using an online research participant recruitment tool, Prolific: 1) healthy adults (n = 237 (female: n = 125; male: n = 111; intersex: n = 1), mean age ± standard deviation (SD) = 36.1 ± 10.7 yr) and 2) type 2 diabetes (T2D) (n = 221 (female: n = 122; male: n = 99), mean age ± SD = 46.5 ± 10.9 yr). The factor structure, internal consistency, test–retest reliability, criterion validity, construct validity, and concurrent validity of PEMSE-Q were determined using exploratory factor analyses, Cronbach’s alpha, intraclass correlation coefficients (ICC), regression analyses, chi-square tests of association and logistic regression, and Pearson correlation and logistic regression, respectively.

Results

PEMSE-Q had good to excellent test–retest reliability (ICC = 0.83–0.94), acceptable criterion validity evidence (all P values <0.001, standard error = 0.033–12.043), moderate concurrent validity (r = 0.449–0.469), and apparent construct validity for public MSE facilities (χ
2 = 5.991, P = 0.01).

Conclusion

PEMSE-Q is a valid and reliable tool for assessing MSE home equipment and accessibility, convenient public MSE facilities, and social support. This tool could be used by researchers, public health professionals, and clinicians to aid in identifying barriers and facilitators to MSE participation.
The effectiveness of deltamethrin, S-bio-allethrin, and piperonyl butoxide 10% in eliminating Aedes in high-risk districts of dengue fever
Authors: Duangdee Jantharaporn , Butsorn Aree , Panya Marutpong
Published: January 2025

Background and aim This quasi-experimental study aimed to investigate the effectiveness of a mixture of 0.5% deltamethrin, 0.75% S-bio-allethrin, and 10% piperonyl butoxide (DAP) in eliminating Aedes mosquitoes in 10 areas of a high-risk district for dengue fever. Methods Susceptibility tests for Aedes against deltamethrin (1:1.000) Aedes) were conducted between October 2022 and December 2022. Data analysis using descriptive statistics was presented with frequency percentage, average, standard deviation, median, at 25 and 75 percentiles, and inferential statistics to compare mean differences within and between groups using independent t-test statistics. Results The results showed that these isolates were susceptible to deltamethrin. The mortality difference rate between DAP indoors was significantly more effective than 0.5% deltamethrin at 0.05 (p-value=0.04). The mortality difference rate between the mortality rate of DAP outdoors was statistically significantly greater than 0.5% deltamethrin at a level of 0.05 (p-value<0.001). The mortality difference means of Aedes caused by DAP indoors and outdoors were statistically different at 0.05 (p-value<0.001), and it was found that the effectiveness of 0.5% deltamethrin in eliminating indoors was greater than outdoors by 70.1 (95% CI = 63.78-76.41). Conclusion Combining DAP effectively eliminated Aedes mosquitoes in indoor and outdoor environments.
Artificial Intelligence (AI) and Healthcare Capabilities: A Systematic Literature Review
Authors: Ferede Dereje
Published: January 2025

Artificial Intelligence (AI) has the potential to transform the healthcare ecosystem, but further research is needed to understand how it can enhance healthcare capabilities. This study analyzes the literature on AI and healthcare capability using the PRISMA approach, applying specific search keywords and inclusion/exclusion criteria. The findings indicate that AI benefits the healthcare ecosystem, significantly influences health outcomes, and transforms medical practices. However, there is limited literature and a lack of understanding regarding how AI enhances healthcare capabilities. Most studies date from 2019, suggesting that COVID-19 has accelerated the adoption of AI systems in healthcare. This research contributes theoretically by developing a framework that clarifies AI’s role in enhancing healthcare capabilities, serving as a foundational model for future studies. It identifies critical gaps in the literature, especially in the Global South, and encourages exploration in under-researched areas where healthcare professionals can benefit from AI. Additionally, it bridges the gap between AI and healthcare, enriching interdisciplinary dialogue relevant to emerging economies facing financial constraints. Practically, the study provides actionable insights for healthcare practitioners and policymakers in the Global South on leveraging AI to improve service delivery. It sets the stage for empirical research, promoting the testing and refinement of the proposed framework in resource-limited contexts, while raising awareness among healthcare staff, managers, and technology developers about AI’s role in healthcare.
Through restful waters and deep commotion: A study on burnout and health impairment of Italian seafarers from the JD-R model perspective.
Authors: Buscema Francesco , Cena Lorenzo , Cricenti Clarissa , Zito Margherita , Bertola Lara , Colombo Lara
Published: January 2025

Background The work experience of seafarers differs significantly from other land-based occupations due to several factors, particularly remoteness and the restricted work environment. This study seeks to examine the impact of burnout and health impairment in the maritime industry, using the Job Demand-Resources theory as a framework. Methods To investigate these phenomena, an online questionnaire was sent to 239 Italian seafarers (94.6% men, Mage = 39.44, SD = 12.8). We tested a mediated Structural Equation Model (SEM) aimed at predicting negative health outcomes. Results The results show that burnout plays a mediating role between job demands (such as workload and cognitive strain) and resources (such as social support and transformational leadership), influencing variables related to health impairment (such as sleep quality and physical well-being). Furthermore, the findings highlight the direct influence of occupational resources on seafarers’ health. Conclusions The discussion highlights the urgent need for more research in the field of organisational psychology in the maritime industry and the discrepancies between these findings, which are consistent with the existing maritime literature, and other studies that do not include seafarers in their sample groups.
Wprowadzenie
Authors: Stopińska-Pająk Agnieszka
Published: January 2025

Aktualny numer Edukacji Dorosłych wyróżnia podjęta w nim problematyka. Dominują teksty ukazujące różnorodność przestrzeni edukacyjnych w zmieniającym się świecie, w których uczestniczą współcześni dorośli ludzie. Wraz z próbami werbalizowania nowych definicji pracy będących pochodną wielkich zmian technologicznych, głównie związanych z AI, oraz wydłużającym się czasem ludzkiego życia, konieczność edukacji i uczenia się ludzi dorosłych, jak piszą Andrew J. Scott i Lynda Gratton „stanie się serią działań zaplanowanych na całe życie” (2023, s. 87). I co istotne, wieloznaczność przyszłości z jednej strony, a nieadekwatność starych wzorców z drugiej strony, jak nigdy wcześniej sprawia, iż dorośli głównie poprzez swoją aktywność i zaangażowanie, podejmowane osobiste decyzje kształtują swoje ścieżki uczenia się, edukacji. Za Marc Auge (2010) warto też podkreślić, iż przestrzenie uczenia się, poprzez jej różnorodne formy, krzyżują się i łączą, tworzą, jak z kolei pisze nasza Autorka Hanna Arciszewska, „przestrzenie hybrydalne”. Różne aspekty owych aktywności uczenia się w różnych miejscach i przestrzeniach, nie tylko związanych z pracą zawodową, odnajdujemy w tekstach niniejszego numeru.
Odrębność i współzależność przestrzeni edukacyjnych studentów. Mityczna hybryda trzech środowisk edukacyjnych
Authors: Arciszewska Hanna
Published: January 2025

Współczesny człowiek zdobywa wiedzę na wielu płaszczyznach z wykorzystaniem różnych metod i strategii. Począwszy od edukacji tradycyjnej (indoor – wewnątrz placówki), uważanej niegdyś za jedyny sposób nauki, po czerpanie wiedzy z najbliższego otoczenia, życia i funkcjonowania (edukacja outdoor – na zewnątrz instytucji), aż po wykorzystanie nowoczesnych technologii i poszukiwanie informacji w przestrzeni wirtualnej. Celem niniejszego artykułu jest przybliżenie charakterystyki wymienionych trzech środowisk edukacyjnych, w których żyje współczesny młody człowiek (student). Wskazane przestrzenie mimo występujących różnic i odrębności są od siebie zależne i wzajemnie się uzupełniają, tworząc przestrzeń hybrydalną – nowy wymiar edukacji młodych dorosłych.
Kompetencje cyfrowe jako metakompetencje w procesie całożyciowej edukacji
Authors: Forma Paulina , Winiarczyk Anna
Published: January 2025

Problematyka dotycząca kompetencji w tym kompetencji cyfrowych jest współcześnie bardzo ważna, ponieważ dotyczy funkcjonowania jednostki. Podejmowanie badań odnoszących się do rozpoznawania uwarunkowań kompetencji i analiza efektów tych wpływów jest zasadne, potrzebne, uzasadnione pedagogicznie i społecznie. Kompetencje cyfrowe (informatyczne) łączą się z kompetencjami informacyjnymi, komunikacyjnymi oraz z kreatywnymi i moralnymi. Są one współcześnie potrzebne każdemu człowiekowi. Coraz częściej dostrzec można, iż kreatorzy procesów wychowania i edukacji (rodzice, nauczyciele) pomagający swoim podopiecznym w poznawaniu świata i innych ludzi, świadomie oraz odpowiedzialnie korzystają z nowych technologii, uczą rozumienia mediów i posługiwania się źródłami informacji. Warto podkreślić, iż współczesny, interdyscyplinarny dyskurs świadczy o implikacji kolejnych ujęć badawczych, opisowych, dający podstawy do tworzenia rekomendacji.
GENEZA I STRUKTURA KOŚCIOŁA WEDŁUG TOMASZA WĘCŁAWSKIEGO/TOMASZA POLAKA
Authors: Artemiuk Przemysław
Published: January 2025

Celem artykułu jest prezentacja genezy i struktury Kościoła, a także ukazanie ich na tle historyczno-teologicznym i wyprowadzenie wniosków dotyczących badanych zagadnień. W części pierwszej autor przedstawił poglądy Tomasza Węcławskiego na kwestię kształtowania się struktury i władzy w Kościele, w części drugiej zaś, sięgając do jego ostatniej pracy, ukazał nowe spojrzenie na genezę Kościoła, określanego po ewolucji poglądów poznańskiego profesora mianem „systemu kościelnego” i podjął jego krytykę. Przeprowadzone badania pozwalają na wyciągnięcie następujących konkluzji: doświadczenia pierwotnego Kościoła w odniesieniu do władzy powinny być dzisiaj inspirujące i nie chodzi w nich jednak o kopiowanie i odtwarzanie sytuacji przeszłych; koncepcję określaną mianem „systemu kościelnego” cechuje wyraźny redukcjonizm; między spojrzeniem Tomasza Węcławskiego na początek Kościoła i kształtowania się kościelnych urzędów a „systemem kościelnym” Tomasza Polaka zachodzi istotna różnica.
EKOLOGIA CZŁOWIEKA JAKO PRZESTRZEŃ OCHRONY OSOBY LUDZKIEJ, JEJ GODNOŚCI I INTEGRALNOŚCI
Authors: Gliniecki Wojciech
Published: January 2025

W artykule autor używa pojęcia ekologia człowieka określając w ten sposób konkretny kierunek działania ludzkiego, które ma w swej celowości chronić nie tylko świat natury stworzonej, lecz także naturę człowieka. W swoich badaniach stawia sobie następujące pytanie: co to znaczy, że człowiek jest w centrum stworzenia i jakie są tego konsekwencje w przestrzeni ekonomii, gospodarki itp? To pytanie otwiera ważną problematykę dotyczącą relacji szeroko rozumianej ekologii środowiska z człowiekiem. Autor dochodzi do wniosku, że w centrum tej relacji powinna być osoba ludzka. Ekologia człowieka stawia osobę ludzką w centrum właśnie po to, aby odkryć go na nowo w jego wymiarze uniwersalnym i w ten sposób zarówno ochronić naturę osoby ludzkiej, a także budować harmonijną relację człowiek – świat przyrody.
LITURGIA EUCHARYSTYCZNA JAKO ŚRODEK EDUKACJI EKOLOGICZNEJ
Authors: Młynarski Jakub
Published: January 2025

Artykuł zarysowuje obecny stan dyskursu teologicznego w kwestii. Jednocześnie wyznacza pilne zadanie teologii, polegające na rozpowszechnieniu swoich odkryć. Jako idealne „narzędzie” do osiągnięcia tego celu proponuje Mszę świętą, która zawiera w sobie całe nauczanie Kościoła. Wymienia przykładowe teksty, symbole oraz znaki zawarte w Eucharystii, które mają przesłanie ekoteologiczne oraz je wyjaśnia. Artykuł zachęca również do prowadzenia formacji liturgicznych, które uzdolniłyby ludzi do pełnego rozumienia treści zawartych w liturgii.
MARYJA W NAUCE O NARODZIE BŁ. KARDYNAŁA STEFANA WYSZYŃSKIEGO
Authors: Szulist Janusz
Published: January 2025

Przedmiotem analiz w artykule jest ukazanie znaczenia Maryi w narodzie w ujęciu bł. kardynała Stefana Wyszyńskiego. Z uwagi na to, iż Kardynał przejawia postawę patriotyzmu terytorialnego, w artykule zostało zaprezentowane znaczenie Matki Bożej nade wszystko dla narodu polskiego. Prymas Tysiąclecia prezentuje klasyczną wykładnię narodu, obecną w naukach społecznych oraz interpretowaną w kluczu teologicznym. Państwa powstają z narodu. Kultura narodowa określa duchowe bogactwo wspólnot politycznych. Postawa Maryi uczy właściwego odniesienia do narodu, przyczyniając się w ten sposób do wzrostu dobra wspólnego. Kościół w Polsce, krzewiący pobożność maryjną, przyczynia się do przełamywania jarzma komunizmu, przywracając obywatelom poczucie własnej podmiotowości. Orędzie proklamowane przez Kościół – z takich miejsc, jak Jasna Góra – służy rozwiazywaniu współczesnej kwestii społecznej w Polsce w odniesieniu do każdej wspólnoty i instytucji.
Doubly Optimal No-Regret Online Learning in Strongly Monotone Games with Bandit Feedback
Authors: Ba Wenjia , Lin Tianyi , Zhang Jiawei , Zhou Zhengyuan
Published: January 2025

Doubly Optimal No-Regret Online Learning in Strongly Monotone Games with Bandit Feedback

Curious about how players can learn and adapt in unknown games without knowing the game’s dynamics? In “Doubly Optimal No-Regret Online Learning in Strongly Monotone Games with Bandit Feedback,” Ba, Lin, Zhang, and Zhou present a novel bandit learning algorithm for no-regret learning in games where each player only observes its reward determined by all players’ current joint action, not its gradient. Focusing on smooth and strongly monotone games, they introduce a bandit learning algorithm using self-concordant barrier functions. This algorithm achieves optimal single-agent regret and optimal last-iterate convergence rate in multiagent learning to the Nash equilibrium. Their work significantly improves previous methods and demonstrates the algorithm’s effectiveness through numerical results in various applications.
Phytochemical Analysis and In-Vitro Anticancer Potential of Musa Paradisiaca L Stem Extract
Authors: Mani Kamaraj , Kumar Amit , Deep Prakash , Kaurav Monika , Ghai Roma
Published: January 2025

Selected medicinal plants possess many phytochemicals that have excellent antioxidant and anti-cell proliferation potential. The banana stem extract (BSE) is also one among them which have many therapeutic values. The objective of the current experiment was to identify and confirm anti-cell proliferation activity using suitable validated in-vitro experiments. Banana stem extract was prepared by traditional extraction method. The presence of various classes of phytochemicals were confirmed using qualitative phytochemical screening tests using a standard protocol. BSE was subjected to cell viability assay for cell proliferation or cell viability using selected five organ types of human cancer cell lines. Suitable chemotherapeutic compounds were used as a reference in the above experiment. The presence of various classes of phytochemicals such as glycoside, tannin, saponin, alkaloids etc were confirmed by reaction test. Cell viability test showed favorable activity with certain types of human cancer cells. Promising inhibitory activity was seen in breast, Colon, Brain, Prostate, and lung cancer. The maximal activity was found at different concentrations in each cancer type. It is also important to note that the activity noticed was in dose-dependent manner and hence we could calculate the IC50 value. The ability inhibition of cell proliferation was encouraging with differential IC50 values. The activity could be due to the presence of various phytochemicals such as alkaloids, tannins, and glycosides in the BSE. Collectively, it can be concluded that the traditional preparation of BSE has significant anti-cancer potential in in-vitro methods. However, the same can be further explored in a suitable novel animal efficacy model with a multiparametric readout to substantiate the claim.
Analysis of Solute-solvent Interactions of l-isoleucine in Aqueous KCl and NaCl Solutions Across Varying Temperatures
Authors: Pathan N. S. , Manik U. P , Mishra P. L.
Published: January 2025

Physicochemical and volumetric properties of of L-isoleucine (ISL) have been studied in the presence of two electrolytes, potassium chloride (KCl) and sodium chloride (NaCl), at temperatures of 283.15K and 293.15K. The empirically measured physical properties such as density and speed of sound have been utilized for the computation of several parameters such as isothermal compressibility, relative association, non-linier parameter, surface tension, adiabatic compressibility etc., These parameters are interpreted in the context of molecular interactions. Because of the structure-making ability of salt ions and the electrostriction of the solvation shells, it is discovered that the compressibility of the solutions and the solvent decrease with an increase in electrolyte concentration and l-isoleucine amount. The obtained parameters indicate that there is a substantial ion-solvent interaction present in the solution. The results underscored the enhanced ion-solvent interactions, ion-pair formation, and structure-stabilizing effects of L-isoleucine in the presence of KCl/NaCl.
Synthesis, Characterization, Antimicrobial Activity, and Applications of Trimethylphenylammonium Bromide
Authors: B V Deepthi , Raj C Isac Sobana , A Seema
Published: January 2025

A quaternary ammonium compound destroys mold, bacteria, viruses, and fungi. Trimethylphenylammonium bromide, a novel quaternary ammonium compound, was synthesized in this study, and its absorbance wavelength and functional groups were determined through spectral characterization studies using FT-IR and UV-visible spectroscopy. Additionally, the acidity and basicity of each synthesized concentration solution were determined by measuring pH fluctuations. Additionally, this article offers comprehensive action against two species of fungi, Aspergillus flavus and Candida albicans, as well as five distinct bacteria. Furthermore, a unique protein solubility test has been conducted. This article also discusses a few uses for Trimethylphenylammonium bromide solution. The effectiveness of Trimethylphenylammonium bromide in reacting against antimicrobial infections is highlighted in this article.
Analyzing Pharmaceutical Compounds through Neutrosophic Over Soft Hyperconnected Spaces
Authors: Devi R. Narmada , Parthiban Yamini
Published: January 2025

Correlation is crucial in the decision-making approach. The foundational concepts of neutrosophic sets and topological spaces within the context of a basic environment is given. It introduces and explores innovative concepts such as neutrosophic over soft semi-j open sets and neutrosophic over soft hyperconnected spaces. Through a numerical illustration, the manuscript demonstrates the application of these concepts to determine the most effective method for a novel pharmaceutical application using a neutrosophic over soft measure of correlation. The findings highlight the practical utility and potential of these new theoretical constructs in enhancing decision-making processes within the pharmaceutical industry.
Bioproduction of Poly-β-hydroxybutyrate (PHB) Using Dairy Wastewater: A Sustainable and Greener Approach
Authors: Narwal Shivani , Jaiswal Shweta , Deswal Tamanna , Kalshan Savita , Yadav Poonam , Yadav Azad , Dhankhar Rajesh
Published: January 2025

Escalating usage of non-degradable plastics is raising significant concern. The search for bio-based degradable alternatives commenced far back, and the burgeoning progress in the development of bioplastics is featured as a critical solution to ongoing plastic pollution. Bioplastics are becoming a promising substitute for petroleum-based plastics, depending on the production source and post-use disposal management. Among all the promising materials, microbially produced polyester and polyhydroxybutyrate (PHB) belong to the polyhydroxyalkanoate (PHA) family and are biocompatible and non-toxic. PHB has remarkable thermal and mechanical properties, making it a potential replacement for ubiquitous plastics. In this study, PHB-producing bacteria were isolated from mangrove soil and checked for PHB accumulation using preliminary and confirmatory staining. Out of a total 25 isolates, 13 were found positive for PHB accumulation. Dairy wastewater was used as a cultivation medium for PHB production; the potential PHB-producing strain was selected for morphological and biochemical characterization up to the genus level and was found to be Bacillus sp (3.6 ±0.15g/L). Extracted PHB was characterized using FTIR, XRD, and TGA; in FTIR, the characteristic peak was recorded at 1724 cm-1, and XRD showed the crystallinity of PHB. TGA curve displayed maximum mass loss between 254-290oC, indicating thermal stability. The outcome of the present study shows that dairy wastewater is an indispensable medium for PHB production in an eco-friendly way.
A critical political analysis of wellbeing support for postgraduate researchers in higher education
Authors: Turnpenny John
Published: January 2025

While improving wellbeing is a prominent policy goal, political analysis of wellbeing is a vital but to date under-researched sub-field. This article is focused on the politics surrounding concern about the wellbeing of postgraduate researchers (PGRs) at higher education institutions in the UK. There have been several recent policy interventions to support PGR wellbeing within the context of ongoing debate about the status of PGRs, including whether they are students or staff. This article asks how and why PGRs’ status ambiguity affects the policy capacities to support PGR wellbeing. It does this through an analysis of capacities to steer, design and benefit from interventions. It is based on 15 interviews with individuals who had prominent leadership roles in recent ‘flagship’ PGR support projects, analysed using reflexive thematic analysis. It shows that while support for PGR wellbeing features prominently in the UK policy context, there appear to be gaps in the effective design and implementation of that support. Specifically, there is evidence of low political capacity at Individual, Organisational and Systemic levels, which leads to significant gaps in operational capacity. These in turn can amplify low political capacity. The article concludes with some implications for a political analysis of wellbeing, consequent policy implications, and some promising lines for future research.
Crip Time in Galdós's Tristana (1892)
Authors: Tsuchiya Akiko
Published: January 2025

Abstract: Drawing on recent developments in feminist and disability studies, this study will examine the intersections of gender and disability in Galdós's Tristana , particularly in relationship to time. Taking as a point of departure disability theorist Alison Kafer's argument that "time is foundational in the production of normalcy," this article will scrutinize the ways in which Tristana's disability, as well as her feminism (both forms of "social deviance"), place her in conflict with the normative narrative timeline that traces the woman's path toward an expected future of marriage and reproduction. By embracing what Kafer calls "crip time" and resisting normative temporality, the disabled protagonist seeks to reclaim her right to a futurity, even as she becomes increasingly marginalized from the center of bourgeois, hetero-patriarchal, ableist society. At the same time, the novel also poses a challenge to hegemonic masculinity through the "fall" of Tristana's oppressor Lope into "crip time" at the end. I will argue that Galdós ultimately challenges the normalizing function of realist narrative through his strategy of reorienting time through the perspective of the disabled female subject, thus opening up possibilities of existence for marginal bodies and subjects previously considered to be invisible and dispensable. Resumen: Basándome en desarrollos recientes en estudios feministas y de discapacidad, en este estudio examino las intersecciones de género y discapacidad en Tristana de Galdós, particularmente en relación con el tiempo. Partiendo del argumento de la teórica de la discapacidad Alison Kafer de que "el tiempo es fundamental en la producción de la normalidad", investigo cómo la discapacidad de Tristana y su feminismo (ambos formas de "desviación social") la ponen en conflicto con la línea temporal narrativa normativa que traza el camino de la mujer hacia un futuro esperado de matrimonio y reproducción. Al abrazar lo que Kafer llama "tiempo crip " y resistir la temporalidad normativa, la protagonista discapacitada busca reclamar su derecho a un futuro, incluso mientras se margina cada vez más del centro de la sociedad burguesa, heteropatriarcal y capacitista. A la vez, la novela desafía la masculinidad hegemónica a través de la "caída" del opresor de Tristana, Lope, al "tiempo crip " al final. Argumento que Galdós finalmente desafía la función normalizadora de la narrativa realista al reorientar el tiempo desde la perspectiva del sujeto femenino discapacitado, abriendo así posibilidades de existencia para cuerpos y sujetos marginales previamente considerados invisibles y prescindibles.
Music, Words, and Moral Cultivation: A Ming–Qing Debate on Qin Songs versus Instrumental Solos
Authors: Wu Zeyuan
Published: January 2025

Abstract: This paper investigates how the relationship between music and words as communicative tools was understood and deployed by the practitioners of the qin (the seven-string zither) in late-imperial China. Qin song, a combination of qin playing and song singing, saw its heyday from the mid-Ming (1368–1644) to the early Qing (1644–1911). However, a debate about whether qin music should be accompanied with lyrics and/or singing also rose during this time, which eventually led to the decline of qin song from the eighteenth century onward. While previous scholars have considered this debate to be mainly about aesthetic preferences, I argue that what was more relevant was the broader Confucian discourse on the roles that music and words play in learning and communicating moral knowledge. By comparing these qin practitioners' arguments and musical works, especially different versions of "Guanju" in the qin repertoire, this paper depicts the chronological and theoretical development of four types of views that shaped the debate. My analysis of these four views suggests that both the rise and fall of qin song were results of the same intellectual trend, which may help us reconsider the late-imperial "philological turn" from a different perspective.