bluuebunny/crossref_metadata_2025 huggingface dataset:
THE CHARACTERISTICS OF NASOPHARYNGEAL CARCINOMA PATIENTS IN MOEHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG JANUARY 2013 - DECEMBER 2017
Authors: Utama Denny Satria
Published: June 2019

Introduction

Nasopharyngeal carcinoma is a malignant tumor that grows in nasopharyngeal area with a predilection in fossa of Rossenmuller and roof of nasopharynx. Nasopharyngeal carcinoma is the most common malignant tumor in the neck and head area. This research is to determine the characteristics of nasopharyngeal carcinoma at Moehammad Hoesin General Hospital Palembang.

Methods

This study design is restrospective descriptive and took the sample from medical records in department of ORL-HNS Moehammad Hoesin General Hospital Palembang between January 2013 until December 2017. Results

In this study, the number of nasopharyngeal carcinoma patients January 2013 to December 2017 was 284 patient. Most of them were male (72.86%). The age of most patients ranges from 41-50 years (33.20%). The highest histopathological description of patients was WHO 2B (54.9%). Most patients were T4 (36.29%). Most patients nodules were N3 (34.09%). As many as 93.88% of patients have not experienced distant metastasis. Most patients came to the department of ORL-HNS had already been in stage IV (63.84%). The most chemotherapy regimens given were carboplatin and docetaxel.

Conclusions

Nasopharyngeal carcinoma is still a problem in many countries. The main management is radiotherapy with or without chemotherapy.
THE ASSOCIATION BETWEEN EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR WITH PRIMARY TUMOR VOLUME OF NASOPHARYNGEAL CARCINOMA
Authors: Utomo Audi Wahyu , Gustarini Indah Asmara
Published: June 2019

Objective: Tumor development was triggered by the excess population of the Epidermal Growth Factor Receptor (EGFR). Expression of EGFR with primary tumor volume of in patients with NPC. Expression of EGFR has a role in the increasing of metastasis, self-renewal, drug resistance and anti-apoptosis. EGFR expression associated with tumors size, positively nodules and advanced tumor stage in NPC patients. High level of EGFR expression by immunohistochemical examination associated with the development, progression and differentiation cell of tumors.

Methods: Using Cross-sectional as study design. Formalin-fixed paraffin-embedded biopsy specimens were obtained. The expression of EGFR was studied with immunohistochemistry using EGFR polyclonal antibody (Bioss, USA). Assessment of the staining was performed by pathologist consultant used histoscore. The Pearson’s correlation test was used to determine the correlation between expression of EGFR and primary tumor volume of nasopharyngeal carcinoma. Statistical significance was defined as p <0.05.

Result: Total samples are 19 patients. The result of EGFR expression in NPC patients with a primary tumor volume of 1-50 ml is 5 samples with a weak positive expression and 4 samples with moderate positive expression. NPC with a primary tumor volume of 51-100 ml is 2 samples of negative expression, 1 sample of weak positive expression, 3 samples with moderate positive expression and 2 samples with strong positive expression. NPC with primary tumor volume >100 ml is 1 sample weak positive expression and 1 sample strong positive expression. Statistical analysis using Pearson’s exact test was obtained p=0.047 with a correlation coefficient 0.461. EGFR expression from all of the patients there was 2 samples (10.53%) negatives, 7 samples (36.84%) weak positive, moderate positive was 7 samples (36.84%), and strong positive 3 samples (15.79%). 

Conclusion: There was an association between the expression of EGFR with the primary tumor volume of nasopharyngeal carcinoma.
Effect of Electrolysis Treatment Time, Field Strength and Recycling Flowrate on Ankistrodesmus sp. Lipid Extraction
Authors: Joannes Costantine
Published: June 2019

The study discusses the effect of Electrolysis Ereatment (ET) parameters focussed on the Electrolysis Treatment Time (ETT), Electrolysis Field Strength (EFS) and Electrolysis Recycling Flowrate (ERF) towards Ankistrodesmus sp. lipid extraction prior to the solvent extraction method. In the ET system selection experiment, the highest lipid content (13.05 ± 0.57 % wt.) attained was from ET system 3 (21V/cm, 140ml/min and 25 min). The three ET parameters were then optimized. The highest lipid content and methyl palmitate gained in ETT was 15.83 ± 0.68 % wt. and 0.440 ± 0.046μg/ml at 20 min, respectively. Meanwhile, the highest lipid content and methyl palmitate obtained in EFS was 15.46 ± 0.78 % wt. and 0.629 ± 0.058μg/ml at 21V/cm, respectively. As for ERF, the highest lipid content and methyl palmitate attained was 15.60 ± 0.67 % wt. and 0.390 ± 0.032μg/ml at 180ml/min, respectively. In comparison to Ankistrodesmus sp. Without Electrolysis Treatment (WOET), the lipid extraction of Ankistrodesmus sp. treated With Electrolysis Treatment (WET) can be improved and had resulted in the increasing of extraction with 1.34, 1.38 and 1.40 times higher in ETT, EFS and ERF, respectively.
Economic Values and CO2 Simulation on the Application of LPG for Public Fleets in Magelang, Indonesia: Executive Data to Support the Clean City Program
Authors: Setiyo Muji , Widodo Eko Muh , Rosyidi Muhammad Imron , Purnomo Tuessi Ari , Rahardja Bayu Sindhu , Suryantoro Suryantoro
Published: June 2019

The implementation of the ASEAN Clean Tourist City Standard caused restlessness among public fleet operators and the Department of Transportation of Magelang City. Therefore, this article presents the prediction of economic value and environmental benefits of public fleet in Magelang that will be converted from gasoline to LPG. Investment feasibility parameters, such as Break Event Point (BEP), Net Present Value (NPV), Internal Rate of Return (IRR), and Payback Period (PBP) are presented through three financing scenarios compared with the current gasoline price at the fuel station, RON 88 and RON 90. Simulation results indicate that investment is feasible with the government providing fiscal incentives through the procurement of converter kits. The wages of the public fleet crew under Minimum Wage City will rise by 30 % and 70 % to switch from gasoline RON 88 and gasoline RON 90, respectively. Meanwhile, environmental benefits are also expected to improve, with CO2 emission reduction of 320.46 tons/year or about 11 % of gasoline usage. These two benefits (economics and environmental) are expected to support the clean city program in Magelang City, Indonesia.
TARI TOPENG IRENG BANDUNGREJO, NGABLAK, MAGELANG
Authors: Setyastuti Budi
Published: June 2019

Penelitian bertujuan menggali bentuk dan fungsi sosial seni dalam adat budaya Bandungrejo. Penelitian menggunakan pendekatan kualitatif yang bersifat deskriptif. Metode pengumpulan data yang digunakan meliputi observasi, wawancara, dokumentasi dan studi pustaka. Teknik analisis data menggunakan deskriptif interpretatif. Penarikan simpulan melalui verifikasi, yang aktifitas terdiri dari reduksi data, sajian data dan laporan hasil penelitian. Hasil yang dicapai Topeng Ireng memiliki makna penting bagi kehidupan masyarakat Bandungrejo. Banyak fungsi yang berperan aktif kesenian rakyat Topeng Ireng bagi masyarakat di antaranya fungsi estetis, hiburan, perlambang, pengesahan lembaga sosial dan ritus kehidupan, pengintegrasian masyarakat, ritual, dan pendidikan. Faktor-faktor pendukung dan penghambat baik secara intern dan ekstern meliputi kondisi dan situasi masyarakat setempat dan kehadiran masyarakat desa sekitar.

Kata kunci: topeng ireng, upacara adat, fungsi, faktor pendukung dan penghambat.

 

The research aims to explore the form and function of social arts in Bandungrejo cultural customs. The Research uses qualitative approaches that are descriptive. The method of collecting data used includes observations, interviews, documentation and literature review. The data analysis uses descriptive and interpretive. Conclusion withdrawal through verification, the activity consists of data reduction, data presentation and research report results. The results achieved by Topeng Ireng have an important meaning for the life of Bandungrejo. Many functions that play an active role in the folk art of Topeng Ireng are among others aesthetic functions, entertainment, symbolism, ratification of social institutions and rites of life, integration of society, rituals, and education. Supporting and inhibiting factors both internally and externally include the conditions and situation of the local community and the presence of the surrounding village community.

Keywords: ireng mask, traditional ceremony, function, supporting and inhibiting factors.
DAMAR KURUNG HASIL AKULTURASI KEBUDAYAAN MASYARAKAT GRESIK
Authors: Azis Firman , Wahyuningsih Novita
Published: June 2019

ABSTRAK
Damar kurung memiliki kemiripan seperti lampion yang berasal dari Cina yaitu sebagai sebuah lentera namun memiliki bentuk yang berbeda. Hal ini disebabkan karena akulturasi yang terjadi di daerah Gresik. Damar
kurung sempat berada diambang kepunahan, namun berkat seorang seniman bernama Masmundari yang mengangkat kembali dan melestarikan damar kurung sehingga masih tetap bertahan sampai sekarang ini. Tujuandibuatnya penulisan ini adalah untuk menjelaskan bagaimana asal-usul damar kurung ini dapat tercipta dan menjadi kebudayaan dari masyarakat Gresik. Pendekatan yang dilakukan adalah dengan pendekatan sejarah dan studi literatur. Sumber informasi atau sumber data didapat dari buku-buku, jurnal, artikel serta gambar atau foto yang berhubungan dengan penulisan ini. Sehingga pada akhirnya dapat ditarik kesimpulan yang dapat diterima oleh masyarakat luas mengenai sejarahdamar kurung yang merupakan peninggalan
kebudayaan dari daerah Gresik. Manfaat dari dibuatnya penulisan artikel ini adalah agar masyarakat bisa menambah wawasan kebudayaan mengenai damar kurung, dan juga sebagai sumber informasi dan
referensitentang damar kurung. Damar kurung masih bisa dilestarikan oleh masyarakat modern, baik oleh orang dewasa maupun oleh anak-anak agar kebudayaan Indonesia khususnya dari daerah Gresik dapat terus dinikmati sampai kapanpun.

Kata kunci: Akulturasi, Damar Kurung, Gresik, Kebudayaan, Masyarakat

.
ABSTRACT

Damar Kurung are similar to Chinese lanterns which have different shapes. This is due to the acculturation that occurred in Gresik area. Damar Kurung had almost been extinct but it still survives today because of the artist named Masmundari who raised and preserved Damar Kurung. The purpose of this writing is to explain how the origins of Damar Kurung that becomes a culture of Gresik community. The approach taken is a historical approach and literary study. Data sources come from books, journals, articles and images or photos related to
this writing. So that the conclusions regarding the history can be drawn and accepted by the community of Damar Kurung which represent the cultural relics from Gresik area. This article is very useful that people can
add their cultural insights about Damar Kurung and besides, it is also as a source of information and references about Damar Kurung. Damar Kurung can still be preserved by modern society, by adults as well as by
children so that Indonesian culture especially from Gresik area can be enjoyed at any time.

Keywords: Acculturation, Damar Kurung, Gresik, Culture, community.
PROSES REVITALISASI TARI PAKARENA LAIYOLO OLEH SANGGAR SELAYAR ART DI KABUPATEN KEPULAUAN SELAYAR
Authors: Primasari Dewi
Published: June 2019

ABSTRAK
Artikel ini merupakan hasil dari penelitian yang memfokuskan pada pokok permasalahan bagaimana proses revitalisasi tari Pakarena Laiyolo oleh Sanggar Selayar Art. Tujuan penelitian ini untuk memahami dan menjelaskan setiap tahap proses revitalisasi yang dilakukan oleh sanggar Selayar Art untuk menghidupkan kembali tari Pakarena Laiyolo. Metode penelitian yang digunakan adalah metode penelitian kualitatif, dengan pendekatan interaksi analisis. Hasil penelitian yaitu memaparkan hasil kajian berupa proses yang dilakukan oleh Sanggar Selayar Art dalam upaya melestarikan tari Pakarena Laiyolo.

Kata kunci: Sanggar Selayar Art, tari Pakarena Laiyolo.

ABSTRACT

This article is the result of a study that focuses on the subject matter of how the process of revitalization of Pakarena Laiyolo dance is by Sanggar Selayar Art. The purpose of this study was to understand and explain each stage of the revitalization process carried out by the Selayar Art studio in order to revive Pakarena Laiyolo dance. The research method used is qualitative research method with an interaction analysis approach. The results describe about results of the study in the form of a process carried out by Selayar Art Studio in an effort to preserve the Pakarena Laiyolo dance.

Keywords: Selayar Art Studio, Pakarena Laiyolo Dance.
Konseling Sebaya Sebagai Pencegahan Perilaku Seksual Berisiko Pada Remaja
Authors: Adyani Sang Ayu Made , Winarsih Wiwin , Fitriyani Poppy
Published: June 2019

Remaja merupakan kelompok berisiko yang mempunyai karakteristik tertentu yang berkontribusi menimbulkan masalah kesehatan, salah satunya adalah perilaku seksual berisiko. Tujuan penelitian ini adalah untuk mengetahui hubungan pemanfaatan konseling sebaya dengan perilaku seksual berisiko pada aggregate remaja di Jakarta Selatan. Desain analisis korelasi dengan pendekatan cross sectional digunakan dalam penelitian terhadap 108 responden yang diperoleh melalui simple random sampling. Hasil analisa chi square menunjukkan bahwa ada hubungan yang signifikan pemanfaatan konseling sebaya dengan perilaku seksual berisiko pada aggregate remaja (p value : 0,003). Hasil penelitian ini menjadi masukan dalam meningkatkan asuhan keperawatan pada aggregate remaja melalui kegiatan konseling sebaya yang lebih memperhatikan kebutuhan perkembangan remaja.
Produktivitas Kerja Perawat Ruang Rawat Inap
Authors: Wahyudi Chandra Tri , Gunarto Catur Septiawan
Published: June 2019

Penelitian ini bertujuan menganalisis pengaruh langsung dan tidak langsung serta besarannya motivasi kerja, beban kerja dan kepemimpinan kepala ruangan terhadap produktivitas kerja perawat ruang rawat inap di RS Bhineka Bhakti Husada (BBH) Tangerang Selatan 2014. Penelitian ini berfokus pada faktor-faktor yang mempengaruhi produktivitas kerja perawat di ruang rawat inap di rumah sakit. Metode penelitian ini menggunakan desain cross sectional pada 80 orang perawat ruang rawat inap RS BBH yang diperoleh dengan tehnik total sampling. Hasil uji koefisien parameter antara beban kerja terhadap produktivitas kerja menunjukkan terdapat pengaruh langsung sebesar 15,57%, sedangkan untuk pengaruh tidak langsung sebesar 2,17%. Hasil lainnya antara motivasi terhadap produktivitas kerja menunjukkan terdapat pengaruh langsung sebesar 26,77%. Hasil uji koefisien parameter antara kepemimpinan terhadap produktivitas kerja menunjukkan terdapat pengaruh langsung sebesar 27,90%, sedangkan untuk pengaruh tidak langsung sebesar 8,22%. Kesimpulan dalam penelitian ini bahwa variabel produktivitas dipengaruhi oleh beban kerja, kepemimpinan, dan motivasi secara stimultan sebesar 80,63%.
Analisis Kemampuan Pemecahan Masalah Matematika dengan Taksonomi SOLO pada Siswa SMA
Authors: Sari Septi Aprillia Luvi , Sutriyono Sutriyono , Pratama Fika Widya
Published: June 2019

Jenis penelitian ini merupakan penelitian kualitatif deskriptif yang bertujuan untuk menganalisis kemampuan pemecahan masalah matematika dengan taksonomi SOLO pada siswa SMA. Subjek dalam penelitian ini terdiri dari tiga subjek yang dipilih berdasarkan nilai raport kenaikan kelas. Subjek tersebut adalah subjek hasil belajar tinggi (S1), subjek hasil belajar sedang (S2), serta subjek hasil belajar rendah (S3). Penelitian ini menggunakan teknik tes, wawancara, dan dokumentasi. Data diambil pada tanggal 8 September 2018 sampai 1 Oktober 2018 di SMA Negeri 2 Salatiga. Berdasarkan hasil penelitian didapatkan S1 dan S2 berada pada ekstended abstrak karena dapat menyelesaikan soal dengan benar serta mampu membuat kesimpulan di akhir pekerjaanya. Sedangkan S3 berada pada tingkat multistruktural karena tidak dapat menemukan solusi yang tepat untuk menyelesaikan soal tersebut.
Penerapan teori bilangan dalam perhitungan kalender tradisional
Authors: Nuraeni Zuli
Published: June 2019

Penerapan teori bilangan banyak digunakan dalam kehidupan sehari-hari salah satunya adalah menentukan hari pasar dalam kalender tradisional.Tujuan penelitian ini adalah untuk menguji konsep dan kemudian dapat diterapkan dan diimplementasikan dalam perhitungan matematis sehingga dapat memfasilitasi dan mendukung aspek kehidupan di luar matematika. Konsep teori bilangan yang digunakan dalam perhitungan kalender tradisional adalah konsep modulo 7 dan modulo 5. Konsep modulo 7 digunakan untuk melihat hari dalam Kalender Masehi sedangkan modulo 5 digunakan untuk melihat hari pasar dalam Kalender Tradisional.
Bahía de Cádiz: lo singular de un territorio múltiple
Authors: Martínez Montiel Luis Francisco
Published: June 2019

Resumen no disponible
Las agrupaciones callejeras del Carnaval de Cádiz, el valor de los espacios no mercantilizados para las relaciones sociales
Authors: Guerrero Quintero Carmen , Al Jende Medina Abel
Published: June 2019

Resumen no disponible
Valoración patrimonial en el diseño de territorios turísticos litorales. La Costa del Sol como modelo de estudio
Authors: Royo Naranjo Lourdes
Published: June 2019

El territorio turístico se presenta como un verdadero laboratorio, consecuencia de la complejidad en las formas y modos de habitar, donde los espacios son capaces de generar maneras distintas de estar en el territorio y diferentes modelos y propuestas de ciudad. Cabría ahora trabajar sobre una de las piezas clave de estos espacios de costa: el paisaje. Al mismo tiempo, la arquitectura turística debe ser entendida, reconocida, valorada e identificada, desde este compromiso de permeabilidad y diversidad, como pieza clave del patrimonio arquitectónico del siglo XX. El conocimiento y valoración de la arquitectura turística ha de responder a la complejidad de sus variantes y condicionantes, impulsos constructivos y deseos de renovación. En este trabajo presentamos un ejercicio de revisión, hasta ahora no realizado, en torno a la valoración patrimonial de la Costa del Sol, con un enfoque multidisciplinar donde el paisaje y la arquitectura turística se convierten en los verdaderos protagonistas.
Paisajes sociales: la visibilidad en la construcción de identidades
Authors: De la Iglesia Salgado Félix
Published: June 2019

Resumen no disponible
Patrimonio oral vivo frente a patrimonio material convaleciente
Authors: Navarro Pedreño José
Published: June 2019

El patrimonio es herencia y como tal, de ella destaca la herencia relevante, que comúnmente entendemos como patrimonio sin más. En el caso de Elche, existen de dos tipos de patrimonio de la humanidad que se perciben de forma distinta, siendo uno limitado en su presencia en el tiempo al ser una representación teatral (Misterio de Elche) y otro permanente en el lugar (Palmeral). La percepción sobre su esencia es distinta en la comunidad. La gestión y mantenimiento, deben asociarse a la percepción positiva de la comunidad, aunque en ocasiones supone perder su originalidad como sucede con el caso del palmeral.
Editorial
Authors: Bari Valéria Aparecida
Published: June 2019

Com base nos novos avanços das Tecnologias da Comunicação e da Informação (TIC), o diálogo se fortificou entre diversos segmentos sociais. A visibilidade foi o maior benefício colhido nessa nova fase da experiência humana. Porém, temos aberto novos caminhos para que se forjem mentiras, vestidas com as roupas da verdade. Temos, assim, notícias que se constroem com base em conteúdos falsos ou falseados, tendenciosos, customizados e disseminados com afinco nas redes sociais, que são repetidas até que sejam aceitas como legítimas.
Faktor-Faktor Yang Mempengaruhi Perilaku Pemeriksaan Payudara Sendiri (SADARI) Pada Mahasiswi Non Kesehatan UIN Antasari Banjarmasin
Authors: Anggraeni Septi , Handayani Eka
Published: June 2019

Cancer is one of the leading causes of death worldwide. In Indonesia, more than 80% of breast cancer cases are found at an advanced stage, where treatment is difficult. Therefore, it is necessary to take preventative measures with early diagnosis through regular routine checks, one of which is by Self Breast Examination (BSE). This study was conducted to determine the factors that influence the behavior of BSE in non-medical students UIN Antasari Banjarmasin with a cross sectional study design with a sample of 50 female students. Data processing analysis includes univariate analysis, bivariate analysis and multivariate analysis with multiple logistic regression statistical tests. Descriptively obtained results that only 13 people (26%) did BSE, respondents' knowledge 38% in good category, attitude towards BSE 84% positive, source of information about BSE 22% in many categories, perceptions of family support 28% supporting and perception about peer support 24% supports. To determine the factors that influence BSE, multiple logistic regression statistical tests were performed which showed the results that there was a joint influence between knowledge, exposure to information sources, perceptions of family and peer support on BSE behavior with a large influence of 35.6 %. To improve the behavior of BSE, it is necessary to increase knowledge, information sources, family and peer support together.

 

Keywords : Knowledge, attitude,  Family support, Information Exposure, BSE
Study of varieties of red clover different types of ripeness and ploidy
Authors: Полюдина Ревмира , Polyudina Revmira , Новоселов Михаил , Novoselov Mikhail
Published: June 2019

For creating new cultivars of red clover it is necessary to use traditional and modern methods: polyploidy, mutagenesis, heterosis and ecological breeding. These methods have been used in breeding for a long time, but it was necessary to modify them to the cultivation of red clover considering its biological fea-tures (perennity, length of vegetation period, winter hardiness) in conditions of harsh continental climate in Siberia. The complex-hybrid population, late maturing, diploid based – the cultivar SibNIIK 10 has been created based on best polycross offspring by polycross method in West Siberia. The winter hardy, early maturing, tetraploid based cultivar Meteor has been created as the result of combination of mutage-nesis, polyploidy, hybridization and selection methods together with FWRC FPA for the first time ever in Siberia. The research cites a comparative study of two cultivars of red clover (SibNIIK 10 and Meteor) of different types of maturity and ploidy by main economically valuable traits. Early maturing tetraploid based cultivar Meteor in herbage and dry matter yield exceeds late maturing cultivar SibNIIK 10 by 9–39 and 7–41% and in seed yield SibNIIK 10 exceeds Meteor by 30%.
Role of acetic acid in the sustainability of silage from cereal grasses to adverse micloflore at air access
Authors: Мамаев Антон , Mamaev Anton , Осипян Белла , Osipyan Bella , Козлова Валентина , Kozlova Valentina
Published: June 2019

To improve the quality of silage, lactic sourdoughs are now widely used. However, the finished high quality feed after air access gradually deteriorates under the influence of aerobic, acid-resistant microorganisms. The most popular compound for increasing aerobic stability is acetic acid. The effect of this acid was studied on plants belonging to the group of lightly consolidated with a sugar-buffer ratio from 2.9 to 3.2 and with an average dry matter content of green mass of 25.6%. Silage, in which the process of homofermentative lactic acid fermentation took place, had significant nutrient losses (on average, in the group of 12.0% dry matter) with rather rapid molding (4.2 days). During aeration, the average pH of this group increased from 4.06 to 5.61. The high level of correlation (0.78) between the content of acetic acid and the time of mold confirm its fungicidal properties. The correlation found, unfortunately, did not guarantee the same high correlation (–0.52) between the content of acetic acid and the loss of nutrients during aeration. This circumstance is apparently due to the high variability of nutrient losses at low levels of acetic acid concentration (less than 4.1% in the dry matter) due to the species composition of the microflora and the speed of its development at the initial stage of aerobic spoilage.
Role of non-traditional fodder crops in fodder production of upper Volga and the scientific basis for their cultivation in single-species and mixed sowing
Authors: Эседуллаев Сабир , Esedullaev Sabir , Шмелева Наталья , Shmeleva Natalia
Published: June 2019

The results of many years of research on the comparative study of single-species and mixed crops of non-traditional forage crops, including festulolium used to create a sustainable forage base balanced in energy, protein and carbohydrates, are presented. The scientific basis for the cultivation of herbs in single and mixed sowing has been determined. It was established that the yield of green mass of festulolium is high-er than that of traditional cereal grasses and on control for an average of three years amounted to 19.8 t/ha, against the background of mineral nutrition — 29.9 t/ha. In mixed sowings, grass mixtures consisting of clover and festulolium and alfalfa and festulolium were distinguished in terms of productivi-ty and fodder value. They provided the harvest of fodder units of 7.95 and 8.65 thousand/ha, with the provision of the fodder unit with digestible protein at the level of the norm or much higher than it — 101–134 g, with an optimal (0.8–1.0) sugar-protein ratio on both backgrounds. The positive effect of grasses on soil fertility, expressed in the accumulation of a significant amount of crop-root residues and nitrogen, is shown. Single-species crops of clover and alfalfa have accumulated 9.83 and 14.8 t/ha of crop-root re-sidues at the control and 10.8 and 19.5 t/ha against the background of mineral nutrition, with which 154, 328 and 253, 431 kg, respectively, were supplied with nitrogen ha, of which symbiotic – 65, 140 and 85, 183 kg/ha.
Struggling with the reccuring reduction of being to knowing: placing thin hope in aesthetic interventions
Authors: Susa Rene
Published: June 2019

This article explores how aesthetic gestures, experiences, interventions might help us make visible certain problematic, enduring, and historically contingent aspects of the troubling ways of being in which we, modern/Cartesian subjects exist in the world. The article does not seek to ultimately suggest some pedagogical strategies or approaches that will help us deconstruct/dismantle these problematic aspects. Instead, it proposes that the common way in which we imagine solutions to our problems, is the very way, through which these problems are being created in the first place. The text pays particular attention to two problematic constitutive characteristics of the modern/Cartesian subject. First is the reductivist insistence on having our being reduced to knowing (Andreotti, 2016) that results in having our relationship to the world mediated (exclusively) through knowledge. Second is our insistence on being able to see/sense/experience ourselves only as separate, presumably autonomous, individuals that ultimately ends up producing us as such..
THE FEASIBILITY OF FAST TRACK PROTOCOL FOR ELDERELY PATIENTS WITH COLORECTAL CANCER
Authors: Zitta D. . , Subbotin V. . , Busirev Y. .
Published: June 2019

Fast track protocol is widely used in major colorectal surgery. It decreases operative stress, shortens hospital stay and reduces complications rate. However feasibility and safety of this approach is still controversial in patients older than 70 years. The AIM of the study was to estimate the safety and effectiveness of fast track protocol in elderly patients with colorectal cancer. MATERIALS AND METHODS. Prospective randomized study included 138 elective colorectal resectionfor cancer during period from 1.01.10 till 1.06.15. The main criteria for the patients selection were age over 70 years and diagnosis of colorectal cancer. 82 of these patients received perioperative treatment according to fast track protocol, other 56 had conventional perioperative care. Patients underwent following procedures: right hemicolectomy (n=7), left hemicolectomy (n=12), transverse colectomy (n=1), sigmoidectomy (n=23), abdomeno-perineal excision (n=19) and low anterior resection of rectum (n=76). Following data were analized: duration of operation, intraoperative blood loss, time offirst flatus and defecation, complications rates. RESULTS. Mean age was 77,4 ± 8 years. There were no differences in gender, co morbidities, body mass index, types of operations between groups. Duration of operations didn't differ significantly between 2 groups. Intraoperative blood loss was higher in conventional group. The time of first flatus and defecation were better in FT-group. There was no mortality in FT-group vs 1,8 %o mortality in conventional group. Complications rate was lower in FT-group: wound infections 3,6% vs 9 %, anastomotic leakage 4,8 %o vs 9 %o, ileus 1,2 vs 5,4 %o, peritonitis 2,4 %o vs 3,6%o, bowel obstruction caused by the adhesions 6 % vs 5,3 %. Reoperation rate was similar 4,8 % vs 3,6 %. CONCLUSION. Fast track protocol in major elective colorectal surgery can be safely applied in elderly patients. The application of fast track protocol in elderly patients improves the restoration of bowel function and reduces the risk of postoperative complication.
VACUUM THERAPY IN TREATMENT OF THE PILONIDAL SINUS DISEASE
Authors: Cherkasov M. F. , Galashokyan K. M. , Startsev Yu. M. , Cherkasov D. M.
Published: June 2019

AIM. To improve results of complex treatment of the pilonidal disease (PD). PATIENTSS AND METHODS. 31 patients with the PD were included into study. Of them in 16 patients postoperative wound was left open and vacuum therapy was applied. In 15 patients postoperative wound was left open and managed by ointment dressing. Groups of patients were well matched in terms of age, gender, degree of inflammation and co-morbidity RESULTS. Application ofvacuum therapy reduced the time of wound healing to 27,5±3,6 days comparing to 79±6,6 days of wounds managed routinely. The mean decrease of wounds' area at POD14 treated by vacuum therapy and without was 60 % vs. 20 % correspondingly. Reduction of pain intensity according to a visual analog scale in group with vacuum therapy (1,5/2,2 vs. 1,8/2,8) and earlier return to original occupation (31±3,9 vs. 39±5,7) was noted. Wound infection developed only in 3/15 (20 %) patients managed by ointment dressing. There was no recurrence of the disease regardless wound management. CONCLUSION. Management of postoperative wound by vacuum therapy in patients after surgery for PD improved results of treatment.
NORMAL VALUES OF ANAL SPHINCTER PRESSURE MEASURED WITH NON-PERFUSION WATER SPHINCTEROMETER
Authors: Shelygin Y. A. , Fomenko O. Y. , Titov A. Y. , Veselov V. V. , Belousova S. V. , Aleshin D. V.
Published: June 2019

There are presented normal values of anal pressure at rest and squeezing measured with non-perfusion water sphincterometer S4402 by MSM ProMedico GmbH. MATERIALS AND METHODS. 73 patients with colon adenomas before polypectomy underwent sphincterometry. All patients had no any complaints of fecal incontinence and outlet obstruction (0 points by Wexner incontinence scale and 0 points by outlet obstruction our clinic scale). Male were 28 (38,4%), average age 56,2± 10,2 years, female - 45 (61,6%), average age 54,9± 13,7 years. RESULTS. Male normal values: average rest anal pressure - 52,1 ± 19,8 mm Hg, maximum rest anal pressure - 60,3 ± 21,9 mm Hg., average squeezing anal pressure - 118,2± 41,5 mm Hg, maximum squeezing anal pressure -174,2± 56,8 mm Hg. Female normal values: average rest anal pressure - 37,1 ± 15,3 mm Hg. maximum rest anal pressure - 43,8± 15,5 mm Hg, average squeezing anal pressure - 75.1 ± 29.5 mm Hg, maximum squeezing anal pressure - 99,1 ± 39,7 mm Hg. CONCLUSION. There were detected normal values of anal pressure at rest and squeezing to use in approximate assessment of anal sphincter function. To perform comprehensive evaluation with this sphincterometer, elaboration of new software is required.
RISK FACTORS OF COMPLICATIONS IN RECONSTRUCTIVE OPERATIONS AFTER HARTMANN PROCEDURE
Authors: Pomazkin V. I.
Published: June 2019

The aim of this work was to analyze early postoperative complications after restoration of bowel continuity in patients which undergone Hartmann procedure for tumor intestinal obstruction and to identify risk factors of complications. 192 patients were included in retrospective study. Early postoperative complications occurred in 18 (9,4%) patients. Univariate analysis showed that COPD increased the risk of complications in 1,7 times (p=0,044), history of septic complications at the previous surgery - in 4,3 times (p=0,011), the third grade of severity of intraperitoneal adhesions in comparison with the 1st grade - in 9,7 times (p=0,001). Multivariable analysis showed that the hazard ratio in patients with complications during the first operation was 4,3 (CI 1,7-23,3, p=0,021), and in patients with the 3d degree of adhesions of 7,5 (CI 1,3 to 15,6, p=0,001).
DIAGNOSIS AND CONSERVATIVE TREATMENT OF FUNCTIONAL DISORDERS OF DEFECATION
Authors: Fomenko O. U. , Titov A. U. , Birukov O. M. , Mudrov A. A. , Belousova S. V. , Egorova D. V.
Published: June 2019

90 patients (female 72 (80%), male 18 (20%), mean age 43,6±16,5 y.o.) with functional disorders of defecation (dyssynergic defecation and inadequate propulsion) were included in the study. All the patients conformed the Rome III (2006) criteria for functional constipation. Highresolution anorectal manometry (HRAM) procedures (London protocol) were performed using Solar GI system (MMS, The Netherland) with 8-channel water-perfusion catheters. All the patients underwent a course of biofeedback therapy for obstructive defecation (Urostim, Laborie, Canada). The course consisted of 10 daily 30-minutes long sessions. Treatment efficacy was evaluated after the completion of biofeedback therapy according to the control HRAM. CONCLUSIONS. Biofeedback is the method of choice for treatment of patients with obstructive defecation syndrome with pelvic floor dyssynergia and spasm of m.puborectalis. At the same time biofeedback therapy is ineffective in patients with type III of manometry pattern and in patients with an inadequate propulsion.
SURGICAL TREATMENT OF THE COMBINED NON-NEOPLASTIC PATHOLOGY OF THE ANAL CHANNEL AND RECTUM
Authors: Borota A. V. , Gulmamedov F. I. , Gulmamedov V. A. , Polunin G. E. , Plahotnikov I. A. , Shalamov V. I.
Published: June 2019

PURPOSE. To evaluate the results of surgical treatment of hemorrhoids in combination with other pathologies of the rectum and anal canal. MATERIALS AND METHODS. 331 patients are operated in clinic concerning non-neoplastic surgical pathology of the anal channel (AC) and the rectum (R) from 2012 to 2015. The probed group (PG) was 159 (48,0±2,7%) patients who underwent combined surgical treatment of hemorrhoids and other pathology AC and R. Control group (CG) was 172 (52,0±2,7%) patients who underwent hemorrhoidectomy. RESULTS. The average duration of surgery in PG was 28±5 min, in CG - 19±3 minutes (p>0.05). The amounts of long-term postoperative complications in the PG was 4,4±1,6/, in the CG - 2,3±1,1% (p> 0,05).The average duration of hospitalization in the PG was 5,1±1,0 days, in СG - 3,2±1,0 days (p> 0,05), the duration of rehabilitation in the PG was 20,3±3,2 days, in CG -15,1±2,0 days (p>0,05). CONCLUSION. Existence of the pathology of AC and R in combination with hemorrhoids is the indication to the combined surgical treatment. The increation in the duration ofsurgery, postoperative complications, duration of hospitalization and rehabilitation in the PG compared with the CG are not statistically significant. Simultaneous surgical treatment of hemorrhoids and other pathologies AC and R relieves the patient from having to perform repeated surgery and its possible complications.
APPLICATION OF NEGATIVE PRESSURE IN THE LOCAL TOPICAL TREATMENT OF OPEN SURGICAL WOUNDS IN PATIENTS WITH PYLONIDAL DISEASE
Authors: Rodoman G. V. , Povarihina O. A. , Cumedy I. R. , Korotaev A. L.
Published: June 2019

AIM to improve results of treatment of patients pylonidal disease. PATIENTS AND METHODS. Thirty two patients with pylonidal disease had a wide excision with postoperative wounds left open. The patients were allocated into 2 groups: in the main group a local negative pressure was used for management of postoperative wounds, while in the control group ointment dressings was used only. Groups were well matched by age, stage of the process and the area of the surgical wound. RESULTS. The use of local negative pressure in the topical treatment of open surgical wounds allowed to reach complete recovery in the main group on 32 ± 5 POD, while in the control group it lasted 41 ± 7 days. No recurrences of the disease in both group were detected. CONCLUSION. Application of the negative pressure in the local topical treatment of open surgical wounds after excision of pylonidal disease accelerates wound healing, helps to avoid the development of suppuration and provide an earlier recovery.
CONTRAST-ENHANCED ULTRASOUND IMAGING OF COLORECTAL LIVER METASTASES
Authors: Mitina L. A. , Stepanov S. O. , Sidorov D. V. , Guts O. V. , Petrov L. O. , Ratushnaya V. V. , Kornietskaya A. L. , Solovyev Y. A. , Lozhkin M. V.
Published: June 2019

At present, aggressive surgical approach in combination with perioperative chemotherapy allows to extend indications for surgical intervention in patients with metastatic colorectal cancer, since only a radical liver resection provides better long-term survival. Contrast enhancement imaging techniques are important before considering treatment options to identify patients with resectable and potentially resectableliver metastases. Our study evaluated the qualitative and quantitative parameters of thedynamic enhancement pattern of liver metastases. This review will be analyzed the results of liver contrast-enhanced ultrasound studies in 104 patients with secondary colorectal liver metastases before primary tumor resection, as well as the monitoring of systemic chemotherapy and post-ablation follow-up to access treatment respond.
SIMULTANEOUS RESECTIONS FOR SYNCHRONOUS COLORECTAL CANCER LIVER METASTASES
Authors: Ponomarenko A. A. , Achkasov S. I. , Panina M. V. , Rybakov E. G.
Published: June 2019

BACKGROUND. The choice type of surgery between staged and simultaneous operations remains an actual issue in patients with colorectal cancer with synchronous liver metastases. The aim of this prospective study is to compare Short-term outcomes of patients with synchronous colorectal liver metastases treated by simultaneous or staged surgery. METHODS. 172 suitable patients were treated in State Scientific Centre of coloproctology named after А.N. Ryzhih, Moscow, Russia between January 2013 and February 2017. Simultaneous colorectal and hepatic resections were performed in 128 patients; 44 patients underwent delayed hepatectomy. Short-term outcomes were compared in patients who underwent simultaneous colorectal and hepatic resection and staged surgery depending on the demographic, clinical and morphological characteristics and type of operations. RESULTS. Median size and number of metastases in the liver were significantly smaller in the group of simultaneous operations: 2.2 cm vs 3.2 cm (p=0.034) and 2 vs 3.5 (p=0.0001), respectively. Major liver resections were rarely performed in group of simultaneous operations: 20 % vs 61 % (р=0,0001). Mortality and complications rates were similar in both groups: 1 % vs 2% (p=0,98) and 30% vs 45 % (р=0,08), respectively. Median days after surgery were also similar in both groups: 14 (12-21) vs 14 (12-21) days, (р=0,6), respectively. Median bloodloss in cases of major liver resections in group of simultaneous operations was lower than in analogical group in staged surgery: 345 ml vs 900 ml (р=0,007), respectively. There was no difference in mortality and complications rates between major liver resections in both groups: 0 vs 4 % (p=0,98) and 52 % vs 48 % (p=1,0), respectively. Rates of acute hepatic insufficiency were similar in both groups of major liver surgery: 4 % vs 11 %, (p=0,36). Median inpatient days were also similar in both groups of major liver surgery: 19 (15-27) vs 19 (11-27) days (р=0,1), respectively. CONCLUSION. Simultaneous operations, requiring economical resections are indicated in cases of synchronous metastases of colorectal cancer in the liver. Simultaneous major liver surgery do not lead to increased bloodloss, complications, mortality rates and inpatient days regardless on type of colorectal surgery in cases of synchronous colorectal cancer liver metastases.
THE ROLE OF NEUTROPHIL-TO-LYMPHOCYTE RATIO (NLR) IN THE DIAGNOSIS OF LOW COLORECTAL ANASTOMOSIS LEAKAGE
Authors: Shelygin Yu. A. , Tarasov M. A. , Zarodnyuk I. V. , Nagudov M. A. , Alekseev M. V. , Rybakov E. G.
Published: June 2019

Anastomotic leakage (AL) following surgical interventions associated with total mesorectal excision (TME) and formation of fistula is the most common and dangerous complication of this kind of intervention, its incidence is 17 %. OBJECTIVE. Determine diagnostic value of Neutrophil-to-Lymphocyte Rato (NLR) in the diagnosis of low colorectal anastomosis leakage after low anterior resection (LAR). Patients and methods: 100 patients with epithelial tumors of rectum in the period 2013-2016 yy underwent surgery - LAR with colorectal anastomosis and preventive stoma. In patients without clinical symptomsrent genological study was performed in order to identify asymptomatic AL on day 7 after the surgery. An incidence of AL, difference in the levels of NLR in patients with AL and consistent anastomosis, we also assessed sensitivity, specificity, positive (PPV) and negative predictive value (NPV) of these markers. RESULTS. AL was diagnosed in 20 % (20/100): in 11 % (11/100) with clinical manifestations, in 9 % (9/100) - without them (contrast leakage according to X-ray examination). In the group of patients with anastomotic leakage, the median of NLR differed from that in patients without compromised integrity of anastomosis at both postoperative day 3 (7,1 vs 5,7, respectively, ((t-test) p=0,042) and postoperative day 6 (6,8 vs 4.4, respectively, ((t-test) p=0,004). Conclusion: an incidence of anastomotic leakage was 20 %, but only 11 % of the patients had clinical manifestations. Changes in the level of NLR in the postoperative period correlated with the fact of AL.
THE POSSIBILITIES OF CONTRAST-ENHACED ULTRASOUND (CEUS) IN THE DIAGNOSIS OF COLORECTAL LIVER METASTASES (CRLM)
Authors: Kovaleva E. V. , Sinyukova G. T. , Danzanova T. Y. , Lepedatu P. I. , Gudilina E. A.
Published: June 2019

AIM. To evaluate the capability of CEUS in the detection of CRLM in comparison with conventional grayscale B-mode. MATERIALS AND Mffl'HODS. 18 patents with CRLM underwent CEUS using the contrast agent SonoVue (Bracco, Italy). The patients were divided into two groups: the first group - 10 (55 %) patients before to chemotherapy; the second group - 8 (45 %) patients after chemotherapy and stable disease. The enhancement patterns of liver metastases were evaluated during the vascular phases: arterial, venous, and delayed. RESULTS. The enhancement patterns of liver metastases on CEUS were categorized as diffuse homogeneous enhancement (30 % - in the first group; such enhancement wasn't observed in the second group), rim-like hyper enhancement (70 % of the patients from the first group, 75 % of patients from the second group) and is enhancement, such as intact liver parenchyma (25 % of the patients from the second group). There were detected additional metastases in 4 (22,2 %) of patients 18 (100 %) in the delayed phase. There were significant differences in time of the beginning the vascular phases between patients from the first and second groups. The latest beginning of the wash-in stage was observed in liver metastases in patients from the second group (25,8 sec. from the injection of the contrast). The earliest beginning of the washout stage was observed in liver metastases in patients from the first group (42,4 sec. from the injection of contrast). CONCLUSION. CEUS improves visualization of CRLM, in comparison with the grayscale B-mode. It is also possible to apply this technique in the assessment of chemotherapy in patients with CRLM, as there was a difference between the moments of the beginning wash-in and wash-out stages.
RISK OF DEVELOPING ACTIVE TB IN IBD PATIENTS TREATED WITH ATNI-TNF
Authors: Frolova K. S. , Borisov S. E.
Published: June 2019

AIM. To develop an investigation complex for IBD-patients with the anti-TNF therapy to decrease the risk of active TB. METHODS. In Moscow Research and Clinical Center for TB Control 454 patients with IBD were screened prior to initiation of anti-TNF treatment and 167 (36,8%) of them - during the anti-TNF therapy. Tuberculin skin test (TST) and chest radiography were used for screening and evaluation of pulmonary adverse effects (every 6 months and additionally in cases of any respiratory signs). RESULTS. Of 454 patients investigated during screening X-ray, chest radiography findings were detected in 29 (6,4%), which required additional investigation, among them in 14 patients, findings considered as residual TB lesions. In the other 15 patients, the radiographic findings caused by previous non-specific pulmonary infections. Positive TST implicates preventive antituberculosis therapy, which was provided 37 patients (before and under anti-TNF therapy). During provided to 167 patients the anti-TNF therapy, were developed pulmonary adverse effects: 10 incidences of active TB lung infection 3 case of sarcoidosis, 1 case of fibrosing alveolitis, and two case of non-CONCLUSION. The patients with IBD, treated by anti-TNF therapy, have a risk of development of a wide variety of infectious and non-infectious pulmonary complications, including TB. It is therefore highly important to carefully monitor the patients prior and during the anti-TNF therapy (every 6 months) for a timely detection of pulmonary conditions potentially associated with the treatment.
LOCALLY-ADVANCED SIGMOID CANCER WITH CARCINOMATOSIS AND MULTIPAY RECURRENCES. 15 YEARS OF OBSERVATION
Authors: Achkasov S. I. , Likhter M. S. , Sushkov O. I. , Nazarov I. V.
Published: June 2019

Peritoneal carcinomatosis is a major reason for treatment failure. However, combination of «aggressive» surgical approach with chemotherapy allows achieving good results. In this clinical case, a locally advanced tumor was presented with large carcinomatous node in anomentum. Cytoreductive surgery with a complete cytoreduction in combination with intra-abdominal chemotherapy prevented generalization of carcinomatosis. Subsequently, the patient underwent three surgeries for repeated local recurrence of colon cancer. A 15-year period of observation of the patient suggests that this approach is promising, which significantly increases the length of patients life expectancy.
DIAGNOSTIC VALUE OF EXOSOMAL MIRNAS FOR COLORECTAL CANCER
Authors: Samsonov R. B. , Tarasov M. A. , Burdakov V. S. , Shtam T. A. , Guljaev A. M. , Tkachenko O. B. , Rybakov E. G. , Filatov M. V. , Aigner A. . , Malek A. V.
Published: June 2019

OBJECTIVE. Assessment of diagnostic significance of exosomal microRNAs analysis in colorectal cancer (CRC). MATERIALS AND METHODS. Plasma samples from 100 patients with colon tumors and 20 healthy donors. Exosomes were isolated by differential ultracentrif ugation the analysis was performed by dynamic light scattering (DLS), cryo-EM, flow cytometry. Quantitative analysis of exosomal microRNAs was performed by RT-PCR. To evaluate the results obtained, the Kraskel-Wallis statistical test and ROC analysis were used. RESULTS. It is shown that CRC causes characteristic changes in the concentration of a number of exosomal microRNAs. Analysis of «reciprocal miRNAs pairs» was proposed as algorithmfor personalized diagnostic of CRC. The optimal parameters of diagnostic values were obtained for miRNA pair«miR-223 / miR-181a» (sensitivity =0.93, specificity =0.88). CONCLUSION. The analysis of exosomal microRNAs presents a promising method for early diagnostics / screening of colorectal cancer.