bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative outcomes of transcorporeal vs trandiscal anterior endoscopic discectomy for cervical radiculopathy: a systematic review and meta-analysis
Authors: Kongtharvonskul Jatupon , Lekha Punyisa , Arirachakaran Alisara , Woratanarat Patarawan , Thakkinstian Ammarin , Keorochana Gun
Published: December 2022

Introduction: In recent years, the anterior transdiscal approach (td) endoscopic cervical discectomy (PECD) can provide direct decompression for central or paramedian cervical disc herniation, the iatrogenic disc damage may result in decreased intervertebral space. Anterior transcorporeal approach (tc) PECD could enable an individual and adjustable trajectory within the vertebral body under different conditions of disc herniation preserving the motion of the adjacent segment. However, there is no consensus regarding which method is better. Material & Methods: This systematic review was conducted according to the PRISMA guidelines. Relevant studies were identified from Medline and Scopus from inception to Octrober 23th, 2022. Results: Twelve studies and 17 were included for analysis of td PECD and tc PECD. One comparative study was included for comparison of td to tc PECD. A pooled UMD of post-operative neck pain, arm pain (VAS) and disability (NDI) scores of transdiscal PECD and transcorporeal PECD were significantly improved when compared to before surgery. The pooled prevalence of having excellent and good results in modified Macnab criteria, complications and reoperation of td PECD and tc PECD were 0.94 (95%CI: 0.92 to 0.96), 0.03 (95%CI: 0.01 to 0.05), 0.03 (95%CI: 0.01 to 0.04) and 0.90 (95%CI: 0.84 to 0.96), 0.08 (95%CI: 0 to 0.19), 0.05 (95%CI: 0.01 to 0.08). By indirect meta-analysis, td PECD have no significantly difference in all outcomes when compared to tc PECD technique. Conclusion: In post-operative outcomes at 3 to 4 years follow-up, there is no significant difference in all clinical outcomes between the 2 approaches. Trial registration number: Prospero registered No 378776
LKB1 loss rewires JNK-induced apoptotic protein dynamics through NUAKs and sensitizes KRAS-mutant NSCLC to combined KRASG12C + MCL-1 blockade
Authors: Hata Aaron , Li Chendi , Syed Mohammed , Shen Yi , Fraser Cameron , Ouyang Jian , Kreuzer Johannes , Clark Sarah , Oh Audris , Walcott Makeba , Morris Robert , Nabel Christopher , Caenepeel Sean , Saiki Anne , Rex Karen , Lipford J , Heist Rebecca , Lin Jessica , Haas Wilhelm , Sarosiek Kristopher , Hughes Paul
Published: December 2022

The efficacy of molecularly targeted anti-cancer therapies may be limited by the presence of co-occurring mutations within a tumor.1-3 Conversely, these alterations may confer collateral vulnerabilities that can be leveraged for the development of novel therapeutic approaches. KRAS mutant lung cancers are distinguished by recurrent mutations in tumor suppressor genes such as TP53 and STK11/LKB1.4 However, clinically actionable targets associated with these alterations are largely undefined. BH3 mimetics targeting distinct pro-survival BCL-2 family proteins have been proposed to enhance the efficacy of targeted therapies, but no biomarkers exist that can predict which patients are most likely to respond. Here we show that inhibition of oncogenic signaling in KRAS-LKB1 mutant lung cancer cells creates a specific dependency on the anti-apoptotic protein MCL-1 for survival. We find that loss of the LKB1-NUAK signaling axis derepresses a JNK-mediated stress response to KRAS or MEK inhibition, allowing inhibitory phosphorylation of BCL-XL that alters BH3-protein interactions and makes cells vulnerable to concurrent MCL-1 inhibition. These results uncover a previously unknown role for LKB1 in regulating the mitochondrial apoptotic response of cancer cells independent of its tumor suppressor activity mediated by AMPK5-7 and SIK8,9 kinases and suggest a fundamental role for LKB1-NUAKs in suppressing the cellular stress response. Additionally, our study reveals a therapeutically targetable vulnerability in KRAS-LKB1 lung cancer cells and suggests a genotype-informed strategy for improving the efficacy of KRAS-targeted therapies.
Impact of pre-enrichment broth on recovery of S. typhimurium and reformed water activity on dominance and endurance of Salmonella in Indian sweetmeat milk (doodh) peda
Authors: Puttananjaiah Mohan Kumari Honganoor , Viswanath Prema
Published: December 2022

Food-borne outbreaks associated with low water activity (aw) foods involve Salmonella contamination, and its control is a significant challenge. In India, milk (doodh) peda is a low aw traditional and popular food. Accordingly, it is essential to determine the prevalence and survival of Salmonella spp. in artificially spiked milk peda stored for an extended period at different aw. Salmonella spp. was not detected in any of the 25 indigenous peda samples. Salmonella did not grow in low aw. However, S. Typhimurium ATCC 25241, which was inoculated artificially at a level of 1.5x104 CFU/g, survived in the spiked peda sample at 0.75, 0.56, and 0.32 aw. Survival of S. Typhimurium ATCC 25241 was observed for a more extended period (19 days) at lower aw than higher aw. These results confirmed that even though Salmonella spp. was not detected in milk peda samples, but can survive for a long time in contaminated samples. Salmonella survived for a long time by the osmoadaptation mechanism. These results revealed that the survival of S. Typhimurium is influenced by aw, and the prevalence of Salmonella in the peda sample was inversely proportional to aw.
Big data mining to screen hub molecular targets related to metabolic abnormalities, intestinal polyps and colorectal cancer
Authors: Ou Shan , Xu Yun , Liu Qinglan , Yang Tianwen , Chen Wei , Yuan Xiu , Zuo Xin , Yao Jie , Shi Peng
Published: December 2022

Purpose
Intestinal polyps and metabolic syndrome (MetS) are closely related to the occurrence and development of colorectal cancer (CRC). This study aimed to provide a potential target for the mechanism analysis between the occurrence of intestinal polyps with metabolic abnormalities and the development of CRC.
Methods
In this study, we used clinical samples of patients with intestinal polyps with MetS (the control group was patients with common intestinal polyps), screened relevant pathways and genes by transcriptome sequencing and public database association analysis, and verified the targets by immunohistochemistry (IHC).
Results
Compared with the control group, 75 up-regulated and 61 down-regulated differential expressed genes (DEGs) were found in MetS patients with polyps. KEGG enrichment showed that these DEGs were mainly involved in cell cycle and mitotic pathways. By association with the public databases CTD and TCGA, 44 CRC-related hub genes were further screened, among which 8 genes showed the same difference trend in the RNA-Seq and GEPIA-COAD databases. Protein interaction analysis showed that PCP4, OLFM1, FN1, TGF-β3 were all related to MAPK signaling pathway. Tumor correlation analysis showed that FN1, PCP4 and TGF-β3 were higher risk genes but OLFM1 was lower risk gene. Immunohistochemical results showed that only OLFM1 was decreased in MetS patients with intestinal polyps.
Conclusion
In intestinal polyps with MetS, the expression of OLFM1 was reduced and may affect mitosis. Under the influence of MetS and the decrease of OLFM1, exosomes and NF-κB pathway may be involved in this process.
Segmentation and morphometric MRI atlas of the chimpanzee cerebellum
Authors: Parks Ashley Nicole , Bryant Katherine L. , Rankin Erica K. , Smaers Jeroen B. , Hecht Erin E.
Published: December 2022

Increased appreciation of the functional heterogeneity of the cerebellum and its contribution to various neuropsychiatric impairments has sparked a resurgence of interest in its comparative anatomy and evolution. Recent evidence suggests that (1) the cerebellar lobules play a prominent role in cognitive, social, and behavioral computations (Desmond et al. 1997; Schmahmann and Sherman 1998; Stoodley and Schmahmann 2009a), and that (2) select portions of the cerebellum may have undergone evolutionary expansion in some lineages of mammals, including humans (Balsters et al. 2010; Smaers et al. 2018), thus creating a need for a higher neuroanatomical resolution of the cerebellum across a broad comparative sample. Here, we provide a detailed magnetic resonance imaging (MRI) atlas of the chimpanzee cerebellum as well as a methodology for the systematic delineation of the vermal and hemispheric lobules. Group averaging across 67 individuals facilitated the characterization of 32 cerebellar masks across the anterior, posterior, and flocculonodular lobes of the cerebellum. A segmentation protocol, including detailed anatomical definitions of each structure, provides the foundation for the construction of future multimodal cerebellar atlases that can deliver insight into cerebellar evolution and pathology.
VGLL3 expression is associated with macrophage infiltration and predicts poor prognosis in epithelial ovarian cancer
Authors: Haque Razaul , Lee Jaebon , Chung Joon-Yong , Shin Ha-Yeon , Kim Hyosun , Kim Jae-Hoon , Yun Jae Won , Kang Eun-Suk
Published: December 2022

Background
High-grade serous ovarian carcinoma (HGSOC) is the most common histologic type of epithelial ovarian cancer (EOC). Due to its poor survival outcomes, it is essential to identify novel biomarkers and therapeutic targets. The hippo pathway is crucial in various cancers, including gynaecological cancers. Herein, we examined the clinicopathological significance of the key genes of the hippo pathway in HGSOC.
Method
The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data were curated to analyse the mRNA expression as well as the clinic-pathological association and correlation with immune cell infiltration in HGSOC. The protein levels of significant genes in the HGSOC tissue were analysed using Tissue Microarray (TMA)-based immunohistochemistry. An overall survival analysis was conducted using the log-rank test method and cox regression analysis. Finally, DEGs pathway analysis was performed to identify find the signalling pathways associated with VGLL3.
Result
VGLL3 mRNA expression was significantly correlated with both advanced tumour stage and poor overall survival (OS) (p = 0.046 and p = 0.003, respectively). The result of IHC analysis also supported the association of high VGLL3 protein with poor OS in HGSOC. Further, VGLL3 expression was significantly associated with tumour infiltrating macrophages. VGLL3 expression and macrophages infiltration were both found to be independent prognostic factors (p = 0.003 and p = 0.024, respectively) for HGSOC. VGLL3 was associated with 3,981 gene expressions (p < 2.04e−4), and with four known and three novel cancer-related signalling pathways, thus implying that VGLL3 is involved in the deregulation of many genes and pathways.
Conclusion
Our study revealed that VGLL3 may play a distinct role in clinical outcomes and immune cell infiltration in patients with HGSOC and that it may be a potential prognostic marker of EOC.
Human papillomavirus affects cervical lesions by regulating the community structure of vaginal flora
Authors: Chen Jinyan , Chen Xuejun , Ma Jiong
Published: December 2022

Background
Continuous infection of high-risk human papillomavirus (HPV) is closely related to cervical lesions. Vaginal flora is involved in pathogen infection and female reproductive tract health, and it is very important to maintain the balance and stability of vaginal microecology. However, the association of vaginal flora and HPV infection has not been completely illuminated.
Methods
Forty patient samples were collected and divided into HPVN, HPN, HPL and HPH groups according to HPV infection and pathological conditions. Vaginal flora of patients with different pathological conditions was detected by 16S rDNA sequencing, and the changes of vaginal flora in 4 groups were analyzed.
Results
The sequencing results showed that at the phylum level, Firmicutes was the main vaginal flora in HPVN, HPN and HPL groups, while Actinobacteria was the main vaginal flora in HPH group. At genus level, Lactobacillus was the main vaginal flora in HPL group, while Lactobacillus and Gardenerella were the main vaginal flora in other groups. Compared with other groups, the community diversity and richness of HPH group were significantly higher. Referring to the species differences of vaginal flora between HPL and HPH groups, Lactobacillus was the dominant population in HPL group, while Bifidobacteriaceae and Enterobacteriaceae were abundant in HPH group. Besides, energy metabolism of flora in HPL group was mainly pH regulation and mucosal formation, while the energy metabolism in HPH group was mainly glucose metabolism.
Conclusions
Regardless of the patient’s pathological condition, the abundance and diversity of vaginal flora in patients infected with HPV would increase. The appearance of specific microorganisms and the change of vaginal flora structure were associated with the progression of cervical intraepithelial neoplasia.
Study on Micromechanical Properties of Gangue Particle Cluster under Uniaxial Compression
Authors: Cheng Lichao , Long Hang , Guo Xiangyu , Li Xinwang , Wang Haixuan , Lu Bin , Hao Yunde , Zhang Xuedong
Published: December 2022

Gangue filling is an important green mining technology, but it is difficult to realize the precise control of the filling and compaction effect, so that the required dense filling rate and filling material parameters cannot be guaranteed. The study of uniaxial compression meso-mechanical properties of gangue particle clusters is of great significance for maximizing the use of gangue filling technology. In this paper, in order to study the mechanical response of displacement, breakage and force chain evolution in the process of compression and compaction of gangue particles, the numerical simulation method based on discrete element is used to establish the model of gangue particle cluster. Through the overflow test, friction physical experiment and steel drum compression test, the compression simulation of gangue particle cluster is carried out, and the physical and mechanical parameters of gangue and the bonding parameters of particle cluster are obtained. The results show that with the compression process, the bonding bond presents the conversion process of bonding-breaking-contact and the crushing sequence of particle cluster tip-whole particle cluster. The formation and extension of the force chain correspond to the fragmentation, displacement and mosaic of the block, and the elongation and penetration of the high stress force chain correspond to the fragmentation of the particle cluster, which will lead to the increase of the stress concentration. The degree of influence on the stress-strain curve of gangue particle clusters from large to small is : particle shape, particle size, loading speed. It provides a theoretical basis for precise quantitative control of gangue solid compaction effect.
Changes in physicochemical characteristics and metabolites in the fermentation of goji juice by Lactiplantibacillus plantarum
Authors: Zhang Xiaojuan , Xie Han , Gao Pengyan , Lu Zhenming , wang Fangzhou , Chai Lijuan , Shi Jinsong , Zhang Huiling , Xu Zhenghong
Published: December 2022

We used untargeted metabolomics based on LC-MS/MS to investigate the changes in metabolites following L. plantarum fermentation of goji juice. Additionally, we assessed the changes in physicochemical characteristics, free amino acid and organic acid levels. Total phenols, total flavonoids, and antioxidant activity improved after L. plantarum fermentation. We screened 31 primary metabolites using multivariate statistical analysis in primary metabolic network. L. plantarum consumed sugars and amino acids in goji juice. Lactic acid, gamma amino butyric acid, and phenylacetaldehyde accumulated after fermentation. Amino acids with bitter taste were converted into acetal derivatives, which contributed to umami and kokumi taste. Indole-3-lactic acid was the top one characteristic secondary metabolite after fermentation. There were 6.25 and 4.19 mg/L indole-3-lactic acid accumulated after fermentation, whereas it was not detected in goji juice. The accumulation of tyrosol was strain-dependent. Fermentation by L. plantarum altered the metabolite profile, improves taste, and increased the levels of several biologically active substances. These results are essential for understanding the bioprocessing of goji juice by L. plantarum.
Deformation Derived Parameters for Automatic Classification of Aortic Stenosis
Authors: Yahav Amir , Adam Dan
Published: December 2022

The timing of valvular manipulation in aortic stenosis (AS) is challenging for asymptomatic patients and is based on reduced ejection fraction (EF). The routinely echocardiographic EF measurement is insensitive to subtle myocardial changes and is also dependent on left ventricular (LV) geometry. Various speckle-tracking echocardiography (STE) derived parameters were found valuable for detecting early LV dysfunction in AS, but only the global longitudinal strain (GLS) is guided due to a lack of robustness. We propose a novel machine-learning-based model, trained over global layer-specific STE parameters for automatic classification of AS. The dataset includes 82 AS patients with severe stenosis, 96 chest pain subjects, and 319 healthy volunteers. The proposed model outperformed with an area under the curve (AUC) of 0.97 for separating between AS patients and healthy volunteers, compared to 0.88 and 0.82 for EF and conventional GLS, respectively. For separating between AS patients and chest pain subjects, the model’s AUC was 0.95, compared to 0.9 and 0.55 for EF and conventional GLS, respectively.
In-store seed purchasing decisions, implications for scaling hybrid maize seed sales through agro-dealers
Authors: Domínguez Ciro , Donovan Jason , Sriniv C.S. , Zanello Giacomo , Peña Meliza
Published: December 2022

The small and medium enterprises that produce improved maize seeds depend on agro-dealers for marketing their hybrids. Yet little is known about how companies interact with agro-dealers for seed marketing and how agro-dealers engage with farmers for in-store decision-making on seed purchases. This study examines farmers' seed purchasing decisions and describes the linkages between companies, agro-dealers and farmers. Data was collected in Chiapas, Mexico in 2019 from farmers after they purchased maize seed in agro-dealer shops (n = 391) and semi-structured interviews with agro-dealers (n = 11) and seed companies (n = 6). Farmers concentrated their purchases on hybrids from multinational companies driven mainly by seed intrinsic attributes (yield, resistance to drought) and quality extrinsic cues (brand and price). Agro-dealers had little influence on farmers' decision-making and their efforts to either engage with seed companies or farmers for the promotion of seeds were low. While agro-dealers were one of the main channels for seed distribution, most promotion activities were developed outside the store and targeted towards end-users. Our review and empirical results show that agro-dealers might be well placed to influence seed purchases decisions, but their role is potentially undermined by product quality cues and out-store marketing stimuli. Besides improving the in-store environment, companies aiming at scaling maize seed sales through agro-dealers need to develop and control seed quality cues, build strong brands, create awareness and loyalty. This requires a pull-push marketing strategy that emphasizes seed customers (farmers) and targets the different stages of the adoption and buying decision-making process.
Slavophil Mirrors (V.I. Lamansky's Criticism of the Perception of Russia and Slavism in German Science)
Authors: Малинов А.В.
Published: December 2022

В статье рассматриваются взгляды крупнейшего отечественного слависта академика Владимира Ивановича Ламанского на немецкую науку. Ламанский относил себя к славянофильскому направлению в русской философии, был создателем учения о трех цивилизационных мирах, для него было характерно антагонистическое восприятие европейской культуры. Определение греко-славянского мира, частью которого является Россия, он дает через противопоставление романо-германскому миру или Европе. Показано формирование негативного образа европейской (немецкой) науки у Ламанского: от непосредственного знакомства с Германией во время научных командировок до несогласия с распространенной в Германии точкой зрения на Россию и славянство. Указаны основные моменты критики Ламанским немецких ученых: опровержение сравнения славян с женщинами, неграми, кельтами, рассуждения о ту-ранстве русских, признание славян низшей расой и т.п. Делается вывод, что отрицательное отношение Ламанского к немецкой науке было вызвано политизацией славянского вопроса, стремлением немецких ученых обосновать неизбежность подчинения славян немцам, отказ славянам в возможности создать самобытную культуру.

The article examines the views of the largest Russian Slavist academician Vladimir Ivanovich Lamansky on German science. Notes that Lamanskii regarded himself a Slavophile trend in Russian philosophy, was the founder of the doctrine of the three worlds of civilization for which was typical of antagonistic perceptions of European culture. The definition of the Greco-Slavic world, of which Russia is a part, is given by him through opposition to the Romano-Germanic world or Europe. The formation of a negative image of European (German) science in Lamansky is shown: from direct acquaintance with Germany to disagreement with the point of view on Russia and the Slavs that is widespread in Germany. The main points of his criticism of German scientists are indicated: refutation of the comparison of the Slavs with women, Negroes, Celts, reasoning of the Russians' outrageousness, recognition of the Slavs as a lower race, etc. Substantiate the inevitability of the subordination of the Slavs to the Germans, the refusal of the Slavs to create an original culture.
A.A. Smirnov as a Celtic Scholar in the light of his theoretical contribution
Authors: Богданова А.А.
Published: December 2022

В фокусе статьи находится кельтологический аспект деятельности известного филолога, переводчика, редактора Александра Александровича Смирнова (1883–1962). В отличие от исследований биографического вектора автор анализирует трансформацию теоретическогобазиса концепций Смирнова о классификации, дефиниции, особенностях кельтских литератур, их контактами с континентальной традицией. Отдельное внимание уделено внутренней рефлексии ученого относительно процессов глобальной кельтологии, достижений отечественных и зарубежных коллег.

The article focuses on the celtological oeuvre of the famous philologist, translator and editor Alexander Alexandrovich Smirnov (1883–1962). Aside from the well-known prosopographical approach, the author concentrates on the analysis of Smirnov's theoretical basis in Celtic Studies: his views related to classification, definition, features of the Celtic Literatures and their connotations with the Old French tradition. The connections between A. Smirnov and international Celtic schools are also thoroughly examined.
Mutual Attraction and Repulsion: Professional Historians and the Dissident Movement in the Second Half of the 1950s-1970s
Authors: Тихонов В.В.
Published: December 2022

Работа подготовлена на основе как опубликованных, так и ранее не вводившихся в научный оборот источников. Впервые привлекаются документы обсуждения весной 1968 г. П.И. Якира в Институте истории АН СССР, отложившиеся в Научном архиве ИРИ РАН. Указывается, что грань между профессиональными историками и диссидентами часто была размытой и подвижной. В статье предлагается скорректировать «диссидентский миф», разделяющий историков на «официальных» и «независимых». Признавая возможность применения концепции «идеология профессионализма» для понимания проблемы, делается вывод, что «идеология профессионализма» включала различные компоненты, актуализируемые учеными в зависимости от их личных качеств и мировоззренческих установок. Также она мешала налаживанию тесных контактов между историками-шестидесятниками и историками-дис-сидентами, поскольку первые выставляли «профессиональный барьер», требующий владения арсеналом навыков научного исследования.

The work is prepared on the basis of published and previously not introduced into scientific circulation sources. The documents of the discussion in the spring of 1968 by P.I. Yakir at the Institute of History of the USSR Academy of Sciences, deposited in the Scientific Archive of the IRI RAS, are involved first time. It is pointed out that the line between professional historians and dissidents was often blurred and mobile. The article proposes to abandon the «dissident myth» that divides historians into «official» and «independent». Recognizing the possibility of applying the concept of «ideology of professionalism» to understand the problem, it is concluded that the «ideology of professionalism» included various components actualized by scientists depending on their personal qualities and ideological attitudes. It also hindered the establishment of close contacts between historians of the sixties and dissident historians, since the former exposed a «professional barrier» requiring possession of an arsenal of scientific research skills.
Social history of consumerism in the woks of Peter Stearns
Authors: Игаева К.В. , Мордвинов А.А.
Published: December 2022

В статье рассматривается концепция консьюмеризма П. Стернса. Анализируются этапы формирования общества потребления и консьюмеристской культуры; обозначаются социальные группы, выступавшие инициаторами данных изменений. Проблематизируются современные противоречия общества потребления: исчерпание его экономического потенциала, растущий разрыв между доходами высшего и низшего класса, кризис модели «догоняющего развития», подчинение будущего ин-тересам настоящего (презентизм). Важная часть анализа этих противоречий у Стернса – выявление тех социальных групп, которые выступают за сохранение общества потребления или его ограничение. Показано, что в современном обществе консьюмеризм становится, с одной стороны, главным терапевтическим средством, позволяющим справиться с растущими индивидуальными и коллективными рисками, с другой – источником структурных противоречий в социокультурной сфере.

The article deals with the concept of consumerism by Peter Stearns. The stages of the formation of a consumer society and consumerist culture are analyzed. The social groups that initiated these changes are identified. The main contemporary contradictions of the consumer society are problematized: the exhaustion of its economic potential, the growing gap between incomes of upper and lower classes, the crisis of the “catch-up development” model, the subordination of the future to the interests of the present (presentism). An important part of the analysis of these contradictions by P. Stearns is their social aspect: identification of social groups that advocate the preservation of the consumer society or its limitation. It is proved that in contemporary society consumption becomes, on the one hand, the main therapeutic tool to cope with growing individual and collective risks, and on the other hand, a key source of a number of structural contradictions in the socio-cultural sphere.
"Seeing" and "Knowing" of Historical Fact in Memorial Discourse and in Reconstructions of Identities
Authors: Наталья Б.С.
Published: December 2022

В статье фокус внимания направлен на оценку в современном мемориальном историографическом дискурсе и в практиках реконструкций идентичностей познавательных возможностей «реляций очевидцев от власти» как отраженной исторической памяти о первом для российского общества опыте реализации права выбора своих индивидуальных, групповых и коллективных преференций в историческом контексте драматических перемен первого десятилетия ХХ века. Центральным в по-вестке методологических дискуссий является вопрос о роли чувственного восприятия исторического факта-события, его «видения», запечатленного в свидетельствах очевидцев, в новой оптике, новых субъективных измерениях для формирования знания об этом факте, то есть «ведения» о нем, как результата процедуры познания исторического факта историком в исследовательских практиках. Экземплификацией подобных практик является предложенная автором статьи реконструкция общественных настроений и мотиваций в процессе самоидентификации в российском обществе на основе интерпретации «видения», зафиксированного в текстах очевидцев, свидетелей и участников.

The article focuses on memorial historiographical discourse as well as on practices of reconstructions of identities, related to evaluation of on informational potential of “eyewitnesses’ reports” of “officials” and considered as reflected historical memory about the first experience of Russian society to demonstrate the right to choose their individual, group and collective preferences within historical context of the dramatic transformations of the first decade of the XXth century. The key question of the agenda for methodological discussions is the role of sensory perception of historical fact, “seeing it”, based on eyewitness-evidence, a new optics, new subjective dimensions of the fact for getting knowledge about it, which means “knowing fact” by means of the procedure of reconstruction of historical fact in the practices of historical research. The exemplification of such kind of practice, related to reconstruction of public sentiments, behavior motivation and the process of self-identification in Russian society, based on historical interpretation of its “seeing” by eyewitnesses reflected in their texts You can also find in the article.
Modeling asymmetric volatility of financial assets using univariate GARCH models: An Indian perspective
Authors: Chalissery Neenu , I. Tabash Mosab , Nishad T. Mohamed , Rahrouh Maha
Published: December 2022

In recent years, numerous models with various amounts of variance have been developed to estimate and forecast important characteristics of time series data. While there are many studies on asymmetric volatility and accuracy testing of univariate Generalized Autoregressive Conditional Heteroscedasticity models, there are no parallel studies involving multiple financial assets and different heteroscedastic models and density functions. The objective of this study is to contrast the forecasting accuracy of univariate volatility models with Normal and Student-t distributions in forecasting the volatility of stock, gold futures, crude futures, exchange rate, and bond yield over a 10-year time span from January 2010 through December 2021 in Indian market. The results of exponential, threshold and asymmetric power models show that the volatility stock (–0.12047, 0.17433, 0.74020 for Nifty, and –0.1153, 0.1676, 0.7372 for Sensex), exchange rate (–0.0567, 0.0961,0.9004), crude oil futures (-0.0411, 0.0658, 0.2130), and bond yield (–0.0193, 0.0514 and –0.0663) react asymmetrically to good and bad news. In case of gold futures, an inverse asymmetric effect (0.0537, –0.01217, –0.1898) is discovered; positive news creates higher variance in gold futures than bad news. The Exponential model captures the asymmetric volatility effect in all asset classes better than any other asymmetric models. This opens the door for many studies in Indian financial market.
Non-waste energy and resource-saving heterogeneous catalytic methods of obtaining and transformation of cyclic acetalies and gem-dichlorocyclopropanes
Authors: Borisova U. G. , Daminev R. R. , Mudrik T. P. , Raskil’dina G. Z.
Published: December 2022

New methods and ways of using heterogeneous zeolite catalysts – H-Y, H-Beta, H-MOR, H-ZSM-5 and micro- meso-porous – H-Ymmm and others in organic synthesis were studied. Using the example of available petrochemical compounds such as polyols, olefins, and dienes, the possibilities of carrying out cyclization and condensation reactions in the presence of zeolites of various structural types are shown. It has been established that the H-Beta zeolite catalyst provides a quantitative yield of ethers and esters during the interaction of olefins – substituted vinyl-gem-dichlorocyclopropanes – with linear alcohols and acids, respectively. It has been determined that the condensation of styrene and an equimolar mixture of 4-hydroxymethyl-1,3-dioxolane and 5-hydroxy-1,3-dioxane in the presence of the H-Beta catalyst proceeds with the formation of ethers, while the ratio of 5 and 6-membered isomeric products = 1.2:1. Multicomponent condensations successfully proceed in one stage in the presence of wide-pore zeolites.
Towards efficient water management in large-scale shale gas fields of China
Authors: Cao Ke-Fan , Zeng Yi , Jin Xue-Shi , Chen Zhuo , Wu Yin-Hu , Hu Hong-Ying
Published: December 2022

China's shale gas industry is developing rapidly, but the associated challenges of water resources shortage and water pollution are becoming more and more prominent. Hydraulic fracturing, the core process of shale gas extraction, consumes a large amount of water and produces refractory wastewater, closely linking shale gas fields with water resources. In this context, this article is to (1) summarize the characteristics of water consumption and wastewater production in typical shale gas fields; (2) introduce the current status of water intake and internal reuse and treatment of shale gas wastewater (SGW); and (3) analyse the challenges of water management in shale gas field. In order to promote the sustainable development of the shale gas industry, it is necessary to establish an efficient water management system according to local conditions. Making use of municipal reclaimed water in fracturing, promoting external reuse of SGW, strengthening the monitoring and safety guarantee of water use, and formulating national or regional water management guidelines can improve the utilization efficiency of water resources in shale gas fields.
Conditions, Resources and Factors Providing Inclusive and Sustainable Economic Growth in Times of 4th Industrial Revolution
Authors: Khvostova A. A.
Published: December 2022

The article summarizes classical and advanced theoretical, methodological and practical approaches to managing conditions, resources and factors providing inclusive and sustainable economic growth. The focus is made on description and identification of the place and role of the 4th industrial revolution. It order to reveal the research subject the author studied findings of academic investigations done by experts in the field of macroeconomics and related branches, such as analysis of economic activity, business-planning, information science, cybernetics, management, etc. The author showed groups of indicators used to find index of inclusive development of economy and their brief characteristics. First of all the opinion of Claus Martin Schwab (Germany), economist, the founder and permanent since 1971 President of the World Economic Forum in Davos was presented dealing with key aspects of arising and progressing of the 4th industrial revolution in global economic space.
Data-Mining as Tool of Multimodal Business-Analysis: Lexical Transformation in Annual Reports of Rostech Corporation
Authors: Mikhnenko P. A.
Published: December 2022

The goal of the research is to study tools of Data Mining to find latent nature of lexical transformation in annual reports of the state-owned corporation ‘Rosteck’ and to estimate perspectives of extending methodology of businessanalysis by tools of multimodal business-analysis. Identification of trends in vocabulary transformation in annual reports was done by finding indicator features of unique key lexical units and their contexts. The author used methods of multimodal business-analysis and tools of Data Mining to study corporate reports in order to identify the most important signs and trends in business-vocabulary transformation at enterprises and corporations, which is usually ignored by conventional business-analysis. Russian texts of annual reports of ‘Rosteck’ corporation for 2017– 2021 act as initial data for the research. As Data Mining tools the author used Workflow-model on the on-line platform for analysis and data visualization Orange Data Mining 3.3.2. The research showed a clear trend to renewal of the annual report content within the period of analysis. Such units as ‘работник’ (worker), ‘обучение’ (training), ‘платформа’ (platform), ‘трансформация’ (transformation), ‘инициатива’ (initiative) and ‘академия’ (academy) demonstrated maximum dynamics in frequency growth. Context analysis allowed the author to draw a conclusion that transformation in business vocabulary is based on the growing attention of the corporation to problems of digital transformation, development of digital platforms, realization of technological and socio-humanitarian strategic initiatives, raising the quality of workers’ qualification by training in corporate net academy. Implementation of these measures requires upgrading strategy of managing finance, corruption, market and other risks. Multimodal business-analysis is a promising trend in academic research and a tool for resolving applied economic and organizational-managerial problems.
Models of Building Organizational Structure of Developing Highly-Technological Enterprises
Authors: Kolychev V. D. , Budanov N. A.
Published: December 2022

The article discusses issues dealing with building organizational structure of developing enterprises by using both quantitative and qualitative criteria. In the research the authors used the best practices of highly-technological companies. To solve the problem of organizational structure upgrading methods of assessing key indicators of organization and its division work efficiency were used. The authors propose a number of criteria and methods aimed at structure upgrading, which could be exploited in applied activity of industrial science-intensive enterprises and organizations. On the basis of mathematical methods of modeling and optimization the authors formulated suggestions concerning rational building of organizational structure and calculating parameters of completeness of structural divisions by administrative and managerial personnel.
Social Tourism for Youth Groups: Key Preferences and Trends
Authors: Donskova L. I. , Barannikov A. L. , Makovetsky M. U.
Published: December 2022

The article studies youth tourism as a part of social tourism and a component of travelling system, which is characterized by social and economic features and impact by different factors and conditions. Theoretical and empiric research of youth tourism is topical, which is stipulated by such qualities of the younger generation as mobility, striving for cognition and today’s possibilities to organize leisure time and travelling. Due to complicated situation connected with COVID-19 and closing borders with foreign countries fast development of internal tourism is observed. The authors underlined specific features of youth tourism and showed its ties with territorial factors and conditions of future development. General academic methods, such as content-analysis, sociological method (survey was conducted among students of universities and colleges) and statistic methods: grouping, average-mean arithmetical ones were used in the research. While studying academic views of home and overseas scientists concerning youth tourism the authors paid attention to the importance of social and cultural components envisaged by travelling motivation for the given group of tourists and the impact of factors and conditions connected with regional features. It was pointed out that to plan the youth tourism development it is necessary to take into account preferences of young people in travel programs and events, various relations in social groups during holidays and travels, paying special attention on social and cultural components.
Analyzing Current Approaches to Assessing the Quality of Software Products
Authors: Drozhkin A. A.
Published: December 2022

Information technologies are the fastest developing industry today both in global economy and economy of Russia. Serious attention is paid to methodological aspects of quality management. Raising quality of software products is an objective of implementing the national project ‘Digital Economy of the Russian Federation’. Processes and stages of software development are modified with regard to new requirements to end product in accordance with adopted home standards. Thus the goal of improving the quality of software products is really topical. The quality of software product is influenced by various determinate and casual external and internal factors. Home experience of managing software quality refers to both western experience and works by Russian scientists, such as G. G. Azgal’dov, Yu. P. Adler, I. G. Venetskiy, V. V. Lipaev, S. D. Il’enkova, I. F. Shishkin, P. L. Chenyshev, V. M. Mishin. The article studies methods of managing software product quality that are used in home IT companies and carries out their comparative analysis. The author formulated proposals aiming at identification of drawbacks by using methods of cognitive modeling.
Interrelation between Ecology and Inflation: Theoretical and Institutional Aspect
Authors: Ramazanov D. I.
Published: December 2022

The article studies the issue of inflation and ecology in theoretical and institutional aspect. We realize the importance of classical factors of inflation, however we would like to highlight such factor as ecology, to be more precise, expenses on providing ecological well-being. In the near future global expenses on ecology can become a considerable reason for price rise. The contribution of ecological well-being to inflation was analyzed from theoretical point of view. The article also explains the mechanism of green inflation development: a growth in nonproduction spending on nature protection at the current stage of output can cause cost rising on average per unit of product. Interrelation between ecology and inflation is shown as a modified Kuznets ecological curve. The graph shows that inflation decreases with rising environmental pollution, but to a certain crucial moment, after which inflation starts growing. The author gives arguments to support the modified Kuznets ecological curve, the major one is the fact that the lower nature-protection costs of the producer that means a high level of pollution, the lower production costs are and thus the lower inflation is and visa verse. The author analyzed results of sociological research that demonstrated that customers are not ready to pay for ecology improvement and price regulation mechanism does not work in this case. In the institutional aspect the fact that price mechanism cannot be used was proved by using the problem of ‘free-rider’ and information asymmetry in regard to ecological well-being as public wealth, which could lead to adverse effects. Certain non-market solutions of the problem of ecology and inflation were proposed.
What Lessons in Managing Public Health System Were Given to Us by Pandemic: Regional Opinion
Authors: Khokhlova T. P. , Nazaretyan V. G.
Published: December 2022

The article highlights key problems in managing public health system in the Krasnodar area during COVID-19 pandemic. It provides findings of the research on public health system functioning in the context of administrative-legal, economic factors and resource potential of the area in 2017–2021. A number of indicators were compared with data of the South Federal district and the Russian Federation in general. The spread of new corona-virus infection in the Krasnodar area became a serious challenge to society, economy and regional business. It was proved that there are certain problems in the region stipulated by the overall stressful situation caused by corona-virus infection, quarantine and other restrictive measures and loss of economic stability of the real sector in economy. Apart from that the public health system of the region faced such problems as management fragmentation, disco-ordination of some components in managerial hierarchy, absence of complex decisions on protection and preservation of people’s health, medical and demographic faults, insufficient accessibility of medical aid, especially in rural areas. Recommendations formulated on the basis of research findings aim at overcoming of identified problems in order to attain the target landmarks in managing public health system in the region. Priority trends in managing public health in view of systematic-functioning approach that supposes introduction of a set of measures, such as goal – setting, planning, coordination and regulation of incidents, as well as implementation of the system of organizational – instructive, administrative, medical-sanitary, preventive and cultural-educational measures. Upgrading management of the public health system in the area could give an opportunity to improve the level and quality of medical service and consequently, the efficiency of industry. It can promote preservation and strengthening health of the population, rising labour activity, reaching serious social and economic parameters of people’s life in conditions of overcoming the pandemic after-effects.
Riscos ocupacionais e sua influência na saúde de policiais penais: uma revisão integrativa
Authors: Bento Cadidé Gleisiane , Cristina Menezes Bêrredo Valéria , Salles da Silva Michele , Aparecida Silva dos Santos Débora
Published: December 2022

Os policiais penais são encarregados de garantir a ordem e segurança nas penitenciárias, estando expostos num ambiente perigoso. Isso somado a jornadas excessivas de trabalho, infraestrutura precária e condições de trabalho inapropriadas podem causar comprometimento da saúde mental desses indivíduos. Tendo isso em vista, este estudo possui o objetivo de realizar uma revisão integrativa por meio de produções científicas do Brasil, para investigar os aspectos emocionais apresentados por policiais penais relacionados aos riscos ocupacionais que podem afetar suas condições de saúde. O presente estudo trata-se de uma revisão integrativa da literatura realizada nas bases de dados eletrônicas SCIELO e LILACS. Desta forma, foram utilizadas pesquisas publicados de 2011 a 2021, na língua portuguesa e de livre acesso. Os estudos apontaram que os policiais penais são submetidos a fatores de risco ocupacionais, condições trabalhistas precárias, rotina de tensão e medo relacionados a insegurança, e estes fatores geram nesses indivíduos perturbação do sono, ansiedade, estresse; comportamentos antissociais, insonia, descontrole emocional que resulta em brigas e conflitos conjugais, agressividade, estado de vigilância, restrição na vida social,  sentimento de solidão, “dessensibilização” quanto aos relacionamentos sociais, tendência ao isolamento social e fragilização dos laços coletivos, sofrimento psíquico, comportamentos com características compulsivas, fenômenos psicossomáticos e agressividade, que resultaram em necessidade de afastamento do trabalho, doenças crônicas e vícios. Pode-se concluir portanto, que são necessárias medidas para minimizar o surgimento de doenças mentais em policiais penais, sendo imprescindível ações para melhoria nas condições de trabalho, ações para promoção da saúde, como atendimento psicológico, e prevenção de doenças nesses trabalhadores.