bluuebunny/crossref_metadata_2025 huggingface dataset:
CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches
Authors: Spiegelberg Diana , Nilvebrant Johan
Published: June 2017

Head and neck squamous cell carcinoma (HNSCC) is a common and severe cancer with low survival rate in advanced stages. Noninvasive imaging of prognostic and therapeutic biomarkers could provide valuable information for planning and monitoring of the different therapy options. Thus, there is a major interest in development of new tracers towards cancer-specific molecular targets to improve diagnostic imaging and treatment. CD44v6, an oncogenic variant of the cell surface molecule CD44, is a promising molecular target since it exhibits a unique expression pattern in HNSCC and is associated with drug- and radio-resistance. In this review we summarize results from preclinical and clinical investigations of radiolabeled anti-CD44v6 antibody-based tracers: full-length antibodies, Fab, F(ab′)2 fragments, and scFvs with particular focus on the engineering of various antibody formats and choice of radiolabel for the use as molecular imaging agents in HNSCC. We conclude that the current evidence points to CD44v6 imaging being a promising approach for providing more specific and sensitive diagnostic tools, leading to customized treatment decisions and functional diagnosis. Improved imaging tools hold promise to enable more effective treatment for head and neck cancer patients.
Effect of Low-Frequency Ultrasonic-Assisted Enzymolysis on the Physicochemical and Antioxidant Properties of Corn Protein Hydrolysates
Authors: Liang Qiufang , Ren Xiaofeng , Ma Haile , Li Suyun , Xu Kangkang , Oladejo Ayobami Olayemi
Published: June 2017

The aim of this study was to investigate the effect of low-frequency ultrasound on the enzymolysis of corn protein. A L9(34) orthogonal design was used to optimize ultrasound pretreatment conditions. Degree hydrolysis (DH), conversion rate of protein (CR), and DPPH IC50were selected as analytical indicators. Under the optimal ultrasound conditions (5 W/L power, 2 s/2 s on/off time, 50°C temperature, and 25 min time), the DH, CR, and radical (DPPH∙,OH∙) scavenging capacities were significantly increased. Molecular weight distribution and amino acid profile analysis showed that ultrasound pretreatment enhanced the formation of short-chain peptides with molecular weight of 200–3000 Da, especially the peptides containing hydrophobic amino acids. Moreover, 40 potential antioxidant peptides were purified by C18 semipreparative column and identified by UPLC-ESI-MS. The results suggest that the optimal ultrasonic-assisted enzymolysis technology could be useful for preparation of antioxidant peptides from corn.
Folic Acid and Homocysteine in Chronic Kidney Disease and Cardiovascular Disease Progression: Which Comes First
Authors: Cianciolo Giuseppe , De Pascalis Antonio , Di Lullo Luca , Ronco Claudio , Zannini Chiara , La Manna Gaetano
Published: June 2017

Background: Hyperhomocysteinemia (Hhcy) occurs in about 85% of chronic kidney disease (CKD) patients because of impaired renal metabolism and reduced renal excretion. Folic acid (FA), the synthetic form of vitamin B9, is critical in the conversion of homocysteine (Hcy) to methionine. If there is not enough intake of FA, there is not enough conversion, and Hcy levels are raised. Summary: Hhcy is regarded as an independent predictor of cardiovascular morbidity and mortality in end-stage renal disease. Hhcy exerts its pathogenic action on the main processes involved in the progression of vascular damage. Research has shown Hhcy suggests enhanced risks for inflammation and endothelial injury which lead to cardiovascular disease (CVD), stroke, and CKD. FA has also been shown to improve endothelial function without lowering Hcy, suggesting an alternative explanation for the effect of FA on endothelial function. Recently, the role of FA and Hhcy in CVD and in CKD progression was renewed in some randomized trials. Key Messages: In the general population and in CKD patients, it remains a topic of discussion whether any beneficial effects of FA therapy are to be referred to its direct effect or to a reduction of Hhcy. While waiting for the results of confirmatory trials, it is reasonable to consider FA with or without methylcobalamin supplementation as appropriate adjunctive therapy in patients with CKD.
Decomposition Algorithms for a Multi-Hard Problem
Authors: Przybylek M. R. , Wierzbicki A. , Michalewicz Z.
Published: June 2017

Real-world optimization problems have been studied in the past, but the work resulted in approaches tailored to individual problems that could not be easily generalized. The reason for this limitation was the lack of appropriate models for the systematic study of salient aspects of real-world problems. The aim of this article is to study one of such aspects: multi-hardness. We propose a variety of decomposition-based algorithms for an abstract multi-hard problem and compare them against the most promising heuristics.
Probabilistic Analysis of the (1+1)-Evolutionary Algorithm
Authors: Hwang Hsien-Kuei , Panholzer Alois , Rolin Nicolas , Tsai Tsung-Hsi , Chen Wei-Mei
Published: June 2017

We give a detailed analysis of the optimization time of the [Formula: see text]-Evolutionary Algorithm under two simple fitness functions (OneMax and LeadingOnes). The problem has been approached in the evolutionary algorithm literature in various ways and with different degrees of rigor. Our asymptotic approximations for the mean and the variance represent the strongest of their kind. The approach we develop is based on an asymptotic resolution of the underlying recurrences and can also be extended to characterize the corresponding limiting distributions. While most of our approximations can be derived by simple heuristic calculations based on the idea of matched asymptotics, the rigorous justifications are challenging and require a delicate error analysis.
Art Let Loose: Autonomous Procedures in Art-Making
Authors: Hosking David
Published: June 2017

This paper proposes the term “autonomous procedures” as a general description of those methods that can be applied autonomously to making an artwork and “systems” as a more specific term for those autonomous methods that fall within the systems theory definition of systems. The text looks critically at the two major proposals for describing and classifying autonomous procedures: Philip Galanter's generative art and the notion of “open systems”; it then proposes a new description: recurrence. Finally it offers a short survey of artworks made using nonrecurrent procedures.
Documenting Media Art: An Archive and Bridging Thesaurus for MediaArtHistories
Authors: Grau Oliver , Haller Sebastian , Hoth Janina , Rühse Viola , Schiller Devon , Seiser Michaela
Published: June 2017

While Media Art has evolved into a critical field at the intersection of art, science and technology, a significant loss threatens this art form due to rapid technological obsolescence and static documentation strategies. Addressing these challenges, the Interactive Archive and Meta-Thesaurus for Media Art Research was developed to advance an Archive of Digital Art. Through an innovative strategy of “collaborative archiving,” social Web 2.0 features foster the engagement of the international media art community and a “bridging thesaurus” linking the extended documentation of the Archive with other databases of “traditional” art history facilitates interdisciplinary and transhistorical comparative analyses.
The Best Interests of the Child in eu Family Reunification Law: A Plea for More Guidance on the Role of Article 24(2) Charter
Authors: Klaassen Mark , Rodrigues Peter
Published: June 2017

The best interests of the child should be a primary consideration in all actions concerning children. This cornerstone of international children’s rights has been codified in Article 24(2) of the Charter of Fundamental Rights of the European Union. In eu family reunification law, the best interests of the child are mentioned in Directive 2003/86/ec on the right to family reunification. However, in the case law of the Court of Justice of the European Union, this concept is not systematically applied in the various types of family reunification cases. In this contribution it is argued that, although the contexts of family reunification cases may be different, from the perspective of the diverse international obligations of the Member States, it would be preferable if the Court systematically involved the best interests of the child concept in all family reunification cases.
Philosophical Exorcism and Pragmatic Sharing of the Unsharable: A Return from Rorty to Dewey through John Cassavetes and David Lynch
Authors: Kuzuu Kenji
Published: June 2017

Richard Rorty’s project of discarding philosophy as a whole suffers a contradictory, self-defeating problem that I call philosophical exorcism. Since Rorty’s understanding of radicality is misleading, when he criticizes philosophy in its entirety, his criticism returns to itself so that his project itself is to be discarded. As a remedy for the exorcism, a different radicality, found in Dewey’s concept of quality, is examined through two films directed by John Cassavetes and David Lynch. The radicality at stake contains a paradox of sharing the unsharable, which distances philosophy from Rorty’s self-defeating pragmatism.
Dogmatic Evidence of “The Given”
Authors: Laera Rodrigo
Published: June 2017

This paper addresses the epistemological problem of the myth of “the given” from an evidentialist and pragmatic perspective concerning the attribution of knowledge: if the evidence supporting p may be based on «the given» for S, how can “the given” be considered the basis of the evidence if it is a myth? The principal objective is to introduce a pragmatic solution to the above question. The main thesis is that there is a dogmatic relationship between the evidence necessary for the legitimacy of our attribution of knowledge and «the given»; however, this dogma does not suggest that these attributions are irrational.
Understandings of the Nation in Russian Public Opinion: Survey Evidence from Putin’s Russia (2001–2014)
Authors: Chaisty Paul , Whitefield Stephen
Published: June 2017

Drawing on surveys conducted in Russia from 2001 to 2014, this article considers citizens’ conceptions of the nation in the Putin period; whether views of the nation have been shaped by political, economic and social developments over this 15 year period; and the correlates of these national perspectives in terms of regime support and political mobilization. We find, first, that understandings of the nation are multidimensional at the mass level, and in part reflect the main nationalist discourses in Russia. Second, we describe how contextual changes over this period – political, economic and social – relate to the ways in which the nation is understood. Third, we consider how different understandings of the nation connect to political attitudes and behaviors. The findings of this research have implications for how we should analyze nationalism and its bases of support in Putin’s Russia.
Authoritarian Learning in the Development of Russia’s Electoral System
Authors: Golosov Grigorii V.
Published: June 2017

The contemporary electoral system of Russia, once adopted to foster the country’s transition to democracy, has been transformed into a crucial pillar of electoral authoritarianism. This study investigates how the principal elements of Russia’s electoral system contributed to the consolidation of the authoritarian political order. While certainly not undemocratic in themselves and often borrowed from well-established democracies, the electoral institutions of Russia were assembled into a combination that effectively prevents alternation in power. The study shows that central role in this process was played by learning from error. At each of the stages of transition to authoritarianism, electoral reforms were implemented in order to minimize the risks that were revealed by the previous electoral experiences of the authoritarian leadership.
An additional record of Fejervarya manoharani Garg and Biju from the Western Ghats with a description of its complete mitochondrial genome
Authors: KIRAN S. KUMAR , ANOOP V. S. , SIVAKUMAR K. C. , DINESH RAGHUNATHAN , MANO J. P. , KAUSHIK DEUTI , SANIL GEORGE
Published: June 2017

An additional sighting of newly described frog species, Fejervarya manoharani Garg and Biju, outside of the type locality along with their morphological data is reported herewith. We are also providing the whole DNA sequence of the mitochondrial genome with its gene organization as additional data to distinguish this species from its congeners. The mitogenome of F. manoharani was 17,654 bp in length. It contains 38 genes including two rRNAs, 23 tRNAs, 13 protein-coding genes and a control region. Similar to other dicroglossid frogs, a tandem duplication of tRNAMet was found. The ND5 gene was located at the 3' end of the control region like in three other Fejervarya species for which mitogenomic data are available. A rearrangement of four tRNA genes, namely Leucine, Threonine, Proline, and Phenylalanine, between ND5 and 12S rRNA, differing from other Fejervarya species, was also observed.
PM2.5 Pollution in China and How It Has Been Exacerbated by Terrain and Meteorological Conditions
Authors: Wang Xiaoyan , Dickinson Robert E. , Su Liangyuan , Zhou Chunlüe , Wang Kaicun
Published: June 2017

The recent severe and frequent PM2.5 (i.e., fine particles smaller than 2.5 µm) pollution in China has aroused unprecedented public concern. The first two years of PM2.5 measurements in China are reported and compared with those of Europe and the United States. The average PM2.5 concentration in China is approximately 5 times that over Europe and America. The contribution of atmospheric dispersion to such air quality is evaluated in this study. Air stagnation or its absence is a good indicator of the atmosphere’s capability to disperse its pollutants, but the NOAA definition of an air stagnation event is found to not be applicable to China since it depends on vertical mixing that is weakened in China by the effects of terrain. To address this deficiency, a new threshold for air stagnation events is proposed that depends on the 10-m wind speed, boundary layer height, and occurrence of precipitation. This newly defined air stagnation closely tracks the day-to-day variation of PM2.5 concentrations. Such events are more frequent over China than over Europe and the United States during autumn and winter, especially over the Sichuan basin and Jing-Jin-Ji region of China. If China had the same frequency of air stagnation as the United States or Europe, 67% and 82% of its stations would improve their current air quality during autumn and winter (e.g., an average of 12% decrease in PM2.5 concentrations for the Jing-Jin-Ji region in wintertime). Its severe pollution and frequent air stagnation conditions make controls on emission less effective in China than elsewhere.
Who Pays for the Next Wave? The American Welfare State and Responsibility for Flood Risk
Authors: Elliott Rebecca
Published: June 2017

In preparing for and responding to natural hazards and disasters, the welfare state establishes a social contract, distributing responsibilities for what will be collectively managed and what will be individually borne. Drawing on archival, interview, and ethnographic data, this article examines the renegotiation of that social contract through the lens of contested efforts to reform the massively indebted US National Flood Insurance Program (NFIP) from 2011 to 2014. In the face of a morally charged debate about deservingness and individual choice, Congress passed legislation that committed to incorporating need-based considerations to the NFIP for the first time. The result defined “deservingness” in terms of ability to pay for risk exposure, qualifying an individualization of responsibility for addressing the problem of flood loss—a problem that might instead demand broader risk sharing, particularly as climate change worsens the threat of flooding.
Associations of Parental Self-Efficacy With Diet, Physical Activity, Body Composition, and Cardiorespiratory Fitness in Swedish Preschoolers: Results From the MINISTOP Trial
Authors: Parekh Niyati , Henriksson Pontus , Delisle Nyström Christine , Silfvernagel Kristin , Ruiz Jonatan R. , Ortega Francisco B. , Pomeroy Jeremy , Löf Marie
Published: June 2017

Background. High parental self-efficacy (PSE) has been associated with healthy diets and higher levels of physical activity (PA) in children; however, data on PSE in relation to body weight and body composition are scarce. The objective of this study was to investigate associations of PSE with measures of diet, PA, body composition, and physical fitness in early childhood. Method. We used baseline data from the MINISTOP trial in healthy Swedish children ( n = 301; 4.5 ± 0.15 years). PSE was assessed using a questionnaire, dietary data were collected using a mobile technology–assisted methodology, and PA was obtained (sedentary behavior and moderate-to-vigorous) by accelerometry. Body composition was measured using the pediatric option for BodPod and cardiorespiratory fitness by the 20 m shuttle run. Linear regression was conducted to evaluate cross-sectional associations of the outcomes in relation to total PSE and scores computed for the individual PSE factors: (1) diet, (2) limit setting of unhealthful behaviors, and (3) PA. Results. Higher scores of total PSE and the diet factor were associated with higher fruit intake (β = 0.82 g/point and 1.99 g/point; p = .014 and .009, respectively) and lower consumption of unhealthy snacks (β = −0.42 g/point and −0.89 g/point; p = .012 and .020, respectively) after adjustment for parental body mass index and education, respondent, and child’s sex and age. No associations were observed between PSE and PA, body composition, or cardiorespiratory fitness. Conclusions. Our study noted that PSE should be considered in conjunction with other strategies for a sustainable impact on childhood obesity.
The effect of economic development incentives and clawback provisions on job creation: A pre-registered evaluation of Maryland and Virginia programs
Authors: Jensen Nathan M.
Published: June 2017

Economic development incentives target individual firms for financial or non-financial benefits to induce capital investment or job creation. Previous studies have found a mixed impact of incentives on economic development, with numerous studies pointing to no impact of incentives on economic growth or job creation. I add to this literature by analyzing two different state economic development incentive programs using the same methods and time-period, allowing for direct comparability. My analysis is the first, “pre-registered” study of incentives, where all of the data collection, design and methodological decisions were made and documented prior to receiving the data. Using a pre-registered matching method design, I estimate the impact of Maryland and Virginia’s flagship economic development incentives on job creation. My main finding is that these incentive programs had essentially zero impact on job creation when they are compared to a control group of similar firms. My secondary results find that even after removing firms from the analysis that were subject to “clawbacks” based on non-compliance with the incentive agreement do not improve the overall performance of the program.
Seismic inversion for geologic fractures and fractured media
Authors: Cui Xiaoqin , Krebes Edward S. , Lines Laurence R.
Published: June 2017

Amplitude variation with offset (AVO) inversion attempts to use the available surface seismic data to estimate the density, P-wave velocity, and S-wave velocity of the earth model. Under linear slip interface theory, synthetic seismograms for models with fractures prove that fractures are also reflection generators. Consequently, observed reflections are not necessarily due to lithologic variations only, but they could be due in part to the effect of fractures. To obtain approximate equations for AVO inversion for fractured media, denoted by AVO with fracture (AVOF), we derived new equations for PP-wave reflection and transmission coefficients that are based on nonwelded contact boundary conditions. In particular, along with the fracture compliances, azimuth has also been taken into account in the equations because the fractures can have any orientation. The new approximate AVOF equations for a horizontally fractured medium with impedance contrast are developed by simplifying the equations for the new PP-wave reflection and transmission coefficients. In the new approximate AVOF equations, the reflection coefficients are divided into a welded contact part (a conventional impedance contrast part) and a nonwelded contact part (a fracture part). This makes the equations flexible enough to separately invert for the rock properties of the fracture and the background medium in the case of a fractured medium with impedance contrast. The new approximate AVOF equations state that fractures could cause the seismic reflectivity to be frequency dependent, and that the fractures not only influence the wave amplitude but also change the wave phase. The linear least-squares and nonlinear conjugate gradient inversion algorithms are applied to estimate the elastic reflectivity using the new approximate AVOF equations. The inverted results for seismic data for a horizontally fractured medium with impedance contrast are evaluated to find a more accurate delineation of the subsurface rock properties.
The best drug treatment for psychotic depression: Antidepressants, antipsychotics or both combined? Commentary On… Cochrane Corner
Authors: Smith Katharine
Published: June 2017

Psychotic depression is a severe condition. Drug treatment (antipsychotics, antidepressants or the combination) or electroconvulsive therapy (ECT) are both effective. However, a 2005 Cochrane review of drug treatments could not find a clear benefit for combination treatment with antidepressant and antipsychotic medication over antidepressants alone. The current updated Cochrane review (2015) incorporated two larger studies and found evidence of superiority for combination treatment. The review was constrained by the small number of available studies and could not address key questions such as the relative merits of antipsychotics and/or antidepressants compared with ECT or ketamine in acute treatment, and which treatments are best for long-term maintenance and prevention of recurrence. However, the methodology used was rigorous and the review gives the best summary to date of the evidence, as well as providing a platform for informing future research.
After a prolonged gestation and difficult labour, informed consent is safely delivered into English and Scots law
Authors: Rix Keith J. B.
Published: June 2017

It is over 40 years since the principle of informed consent was accepted in the USA and it has been long established in other common law jurisdictions. But for decades English law has been constrained by theSidawaycase, which effectively perpetuated a form of medical paternalism. Nevertheless, a patient-centred approach can be traced to one of the judgments in that case, and in the case ofMontgomerythe Supreme Court has now adopted an approach to consent which is based on self-determination and autonomy and is more closely aligned to professional practice. It calls for a dialogue between doctor and patient, recognition of the patient's right to make a choice and recognition by the doctor of their duty to provide the comprehensible information necessary for the patient to exercise choice, having regard to what a prudent patient, in that patient's circumstances and with that patient's characteristics, would want to know.

Learning Objectives

• Understand how the principle of informed consent has emerged in UK law

• Understand the principle of informed consent

• Know how to apply the principle of informed consent to the practice of psychiatry
Creation and Execution of a Novel Anesthesia Perioperative Care Service at a Veterans Affairs Hospital
Authors: Alvis Bret D. , King Adam B. , Pandharipande Pratik P. , Weavind Liza M. , Avila Katelin , Leisy Philip J. , Ajmal Muhammad , McHugh Michael , Keegan Kirk A. , Baker David A. , Walia Ann , Hughes Christopher G.
Published: June 2017

Physician-led perioperative surgical home models are developing as a method for improving the American health care system. These models are novel, team-based approaches that help to provide continuity of care throughout the perioperative period. Another avenue for improving care for surgical patients is the use of enhanced recovery after surgery pathways. These are well-described methods that have shown to improve perioperative outcomes. An established perioperative surgical home model can help implementation, efficiency, and adherence to enhanced recovery after surgery pathways. For these reasons, the Tennessee Valley Healthcare System, Nashville Veterans Affairs Medical Center created an Anesthesiology Perioperative Care Service that provides comprehensive care to surgical patients from their preoperative period through the continuum of their hospital course and postdischarge follow-up. In this brief report, we describe the development, implementation, and preliminary outcomes of the service.
Genealogia da derrota: A reedição do livro O negro no futebol brasileiro e a construção do significado da Copa do Mundo de 1950 para o Brasil
Authors: De Hollanda Bernardo Borges Buarque
Published: June 2017

O artigo propõe um debate sobre a construção da memória coletiva no jornalismo esportivo, tendo por base os episódios relacionados à derrota da seleção brasileira de futebol na Copa do Mundo de 1950, realizada no Brasil. O argumento proposto sustenta que a reedição da obra “clássica” de Mário Filho, O negro no futebol brasileiro (1947), ocorrida em 1964, foi condicionante do modo como o memorialismo esportivo passou a narrar e a valorar o desempenho do selecionado nacional em 1950. Inexistente na primeira edição, posto que prévia à realização do Mundial, não obstante motivada pelo evento para sua publicação, a eleição dos fatores explicativos da perda do título – de ordem racial, moral e política– balizou desde então a relação entre história e memória, entre lembrança e esquecimento, tanto na segunda edição do livro de Mario Filho quanto nas investigações jornalísticas que o sucederam. Estas, por seu turno, tiveram na realização de uma nova Copa do Mundo no Brasil, em 2014, significativo impulso editorial para reativar e para cristalizar essa representação de um evento histórico esportivo. Palavras-chave: Futebol, Copa de 1950, Memorialismo esportivo, Mario Filho, O negro no futebol brasileiro
Optimizing Site Qualification Across the Supply Network at Western Digital
Authors: Liao Bo , Yano Candace Arai , Esturi Shiva
Published: June 2017

We describe an optimization-based methodology that Western Digital implemented to support its site-qualification decisions; that is, which sites(s) are qualified to produce each of its products. Qualifying a product at a site commonly takes several months and hundreds of hours of engineering effort. These decisions are especially challenging because Western Digital Silicon Operations offers thousands of products; and demands more than a month or two into the future are very uncertain, as they are with many electronic products. Therefore, because shortages result in lost sales, the company must consider both expected demand and demand uncertainty. We solve the problem as a mixed-integer stochastic program with multiple stages of recourse, using a linear programming solver for the recourse stages and a greedy heuristic to determine the site qualifications. Western Digital deployed the model starting in the first quarter of 2015 and established a quarterly process for making site-qualification decisions. The decision support tool facilitated a more streamlined decision process and has already provided substantial savings to Western Digital.
Product Portfolio Management with Production Flexibility in Agribusiness
Authors: Bansal Saurabh , Nagarajan Mahesh
Published: June 2017

The acquisition of production flexibility is a well-documented strategy pursued by many firms to counteract certain operational constraints. However, these flexibilities can increase the complexity of a production system and the difficulties in managing increased complexity may hinder exploiting the full benefit of flexibility. In this paper, we consider one such flexibility paradox at an agribusiness firm for an annual $800 million production decision: The firm produces a number of products (hybrid seeds) using limited inventories of several raw materials (parent seeds) and a production process that is subject to random variations. To handle the raw material availability constraint and to partially mitigate the supply risk, the firm invests in a costly second production in South America that can be used if the yield in the first production in North America is low. We solve this joint problem of raw material allocation and sequential production by reformulating it as a tractable simultaneous optimization problem. This tractable reformulation provides an exact solution in practical time durations for large assortments of products. We also establish that when profit margins are sufficiently high, sequential production has less cost, on average, than single production. The solution developed is in use at the firm and has led to an estimated increase in profit by 2%–3% annually.
Nurses on the front line
Authors: Harrison Penny
Published: June 2017

Penny Harrison, Senior Lecturer in Adult Nursing at De Montfort University, Leicester, looks at the strengths and weakness of the new King's Fund report
Tears and laughter in the hall: hearing the human story
Authors: Holmes Mark
Published: June 2017

Mark Holmes of the British Association for the Study of the Liver Nurse Forum discusses bringing the voice of service users into nursing presentations
Working with residents to help prevent infections in the home
Authors: Aziz Ann-Marie
Published: June 2017

Infections in care homes pose a significant threat to the older people who live there. In this article, Ann-Marie Aziz provides an overview of the common infections that residents and staff should be aware of, and how both can be involved in minimising risk
Continuing professional development: undertaking CPD
Authors: Ashurst Adrian
Published: June 2017

Continuing professional development is one of the key components of completing revalidation. In this article, Adrian Ashurst outlines the different learning and development opportunities available to registered nurses as they revalidate
Femme fatales and the positioning of the Ripper in Roy Ward Baker’s Dr Jekyll and Sister Hyde
Authors: Thompson Matthew
Published: June 2017

Much has been made of the way that many portrayals of Jack the Ripper travel upon a familiar narrative path, where the morally questionable prostitutes are rendered helpless by a lone male figure lurking in the dark alleys of 1888 Whitechapel. However, such a construction of the Ripper has resulted in an often reductive perspective on Victorian society, with many films regarding it as divided into either ‘proper’ Victorians who followed the true gender norms of their time, or outliers who instead subverted these very ‘moral’ notions. Roy Ward Baker’s film Dr Jekyll and Sister Hyde (1971) attempts to subvert these ideas by incorporating both the Ripper figure and Robert Louis Stevenson’s gothic characters, both of which have been intertwined in the past. In Dr Jekyll and Sister Hyde, though, Baker goes further by constructing two Rippers – one in the male scientist Dr Jekyll and the other in the female Mrs (or Sister) Hyde. Though the former can be attributed to many tropes that have become associated with the Ripper, the latter challenges not only archetypes of the Whitechapel Murderer but also greater questions of gender and transgression within Victorian society. Indeed, Hyde’s methods of greater autonomy within a patriarchal society bring to mind Slavoj Zizek’s notions of the femme fatale. This article will therefore argue how Baker’s film, through its portrayal of both Jekyll and Hyde, exhibits a greater willingness to challenge old notions of Victorian gender politics. Furthermore, it will show how these two ‘Rippers’ symbolize various fears and anxieties about the Victorian society and of the Ripper in particular.
‘Return to Origin Is Non-Existence’: Al-Mada’in and Perceptions of Ruins in Abbasid Iraq
Authors: Johnson Sarah Cresap
Published: June 2017

By looking at early Abbasid writers in ninth- and tenth-century Iraq, this article will analyse the way in which the physical presence but implied immateriality of ruins has contributed to identity formation in the early Islamic period. Since the pre-Islamic period, inspiration in Arabic
poetry has stemmed from the visualization of ruins. Abbasid writers treated ruins with an uncertain reverence, at once fearing their implications and admiring their abandoned beauty. Ruins have largely been dismissed as toponyms rather than material spaces in Abbasid writing and poetry. This
article attempts to show the connections between the writers’ visualizations of physical ruins and their literary manifestations. In Abbasid Iraq, ruins sat in close proximity to but on the periphery of new Islamic cities. This is especially true in the case of the pre-Islamic ruins
of al-Mada’in, which were located close to Baghdad. The distant presence of the ruins allowed for them to be revered almost as a shrine within the literary discourse, but also to be feared as a sign of decadence and of inevitable decay.
Heritage Crusades: Saving the Past from the Commons
Authors: Straughn Ian B.
Published: June 2017

The early 2014 bombing in Cairo that severely damaged the newly renovated Islamic Art Museum was reported as part of a list of incidents that indicated the precarious state of cultural heritage in the Middle East. In light of such events, this article queries the following: does the
cultural heritage of the Middle East need saving? If so, by, from and for whom? In exploring the moral discourses and political motivations that anchor such calls for intervention, I examine how notions of care manifest themselves in heritage practice. In response to the moral outrage that
often accompanies acts of cultural destruction, this research suggests the possible expansion of the ethical framework by which the material past becomes part of social life. Through an investigation into local engagement with artefacts and historical sites, specifically the sabbakhin in Egypt
and contemporary agriculturalists in northern Syria, I describe forms of vernacular heritage linked to unstated assertions to the commons. At stake is a reframing of the hegemonic discourses of heritage management, one that often reads such activities as mere materialism unable to cultivate
the correct cosmopolitan disposition for how the past should be valued. Ultimately, this article highlights the risk in overstating ideological forms of destruction as the cultural norm associated with Muslim societies.
Prehistoric trepanation in the Iberian Peninsula: A new case from the province of Badajoz (Extremadura, Spain)
Authors: Tomé Tiago Pedro Ferreira
Published: June 2017

Trepanation is a recurrent subject in the literature, with the earliest known examples of this surgical procedure belonging to the Mesolithic/Neolithic periods. The Iberian Peninsula is no exception to this tendency, where most of the known trepanation cases were found in coastal areas.We present one skull with a lesion/trauma compatible with a trepanation on the right parietal bone, recovered from a cave located in southern Badajoz province, inland Spain, Cueva de los Postes. This is the first reported case of a prehistoric trepanation in this region. A brief comparative analysis with other known Iberian prehistoric trepanations is included, regarding location of the lesions and method of trepanation selected to the procedure.
PENGARUH KONSEP POLA GRID TERHADAP KEMAMPUAN JANGKAUAN LANSIA DI KELURAHAN KROBOKAN
Authors: Pratiwi Busada Eka Kristi , Suprapti Atiek , Murtini Titien Woro
Published: June 2017

Elderly is people who aged 60 years and older and generaly has decreased physical and psychological. Thenumber of elderly in Kelurahan Krobokan has reached 8.9%, its means that the region can be said to havean old structure. Elderly in Kelurahan Krobokan can still use their environment can still use theirenvironment to get to a certain social facilities to meet their needs. Existing spatial pattern in the district isusing a grid that has a lot of intersections. The purpose of this study was to determine the physical aspects ofthe elements forming a regular grid patterns that exist in the area of research, so as to affect the nonphysicalaspects of the ability range of the elderly.Research methods that will be used is a qualitative method rationalistic. Where the assessment is used toform a grand theory of concept consisting of the variables that will be connected. Then the data analysisstarts from reviewing and systematics of data that has been obtained by grouping data into variables thathave been previously determined. The group is then presented in the form of maps, patterns, percentages andnarrative text. The data that has been arranged, then made a conclusion and interpretation.An analysis found that the grid pattern affect the ability of elderly to use their environment. The positiveinfluence that can reach the elderly Kelurahan Krobokan social facilities they want them to go the distanceeven beyond their ability.
Influence of Different Luting Agents on the Marginal Discrepancy of Procera® AllCeram Alumina Crown Copings – An Experimental Study
Authors: Pilathadka Shriharsha , Slezák Radovan , Vahalová Dagmar , Kudiyirickal Marina George , Sukumar Sujith
Published: June 2017

Two maxillary first molars and two central incisor typhodont teeth were prepared with 0.8 mm chamfer, 2.0 mm occlusal reduction, and 6 degree taper. The prepared teeth were duplicated 9 times to obtain 36 die stone models and divided into three groups (n = 12). Luting agents tested were zinc phosphate, glass ionomer and resin cement. Procera®AllCeram 0.6 mm coping was fixed with a calibrated finger force of 50 N. The absolute marginal discrepancy was measured using the scanning electron microscope on four axial walls with 4 measurements on each wall to obtain a total of 16 readings for one tooth. Mann Whitney U test was applied to find significant differences between luting cements and Kruskal Wallis tests among groups. Results The absolute marginal discrepancies of cements were in reducing order zinc phosphate (AZ) 53 μm; resin (AR) 44.5 μm, glass ionomer (AG) 29 μm. There was a significant difference among luting cements AG V/s AZ (p = 0.001) and AR V/s AG (p = 0.003), except AR V/s AZ (p = 0.213). All axial surfaces except mesial showed a significant difference. Conclusion The study concluded that different luting media have a definite effect over the final fit of AllCeram coping. Absolute marginal discrepancy was within the accepted level of 100 μm. Distal axial surface demonstrated a wider gap among all the luting agents.
Platonic Ideas and Appearance in Aristotle’s Topics
Authors: Schiaparelli Annamaria
Published: June 2017

This study offers a new interpretation of a well-known Aristotelian argument against some basic tenets of Plato’s theory of Ideas. The argument is formulated in
Ruinenlandschaften und Landschaftsruinen in der gelehrten Literatur der frühen Neuzeit
Authors: Korenjak Martin
Published: June 2017

The “discovery” of the landscape and the growing interest in ruins in early modern times have been the objects of intense research over the last decades. The interaction between these two developments, by contrast, has only rarely been studied, and if so, mainly with regard to the visual arts. Within the literary tradition, only the travel literature of the 18th and 19th centuries has received any attention. How the relationship of landscape and ruins was conceived in the learned, mostly Latin literature of earlier centuries has never been examined in any detail. The present article tries to make good on this deficit. In the first section, it is shown how, from the Renaissance onwards, ruins came to be seen as an integral part of certain landscapes. This development was complemented by a perception of landscapes as ruins from the 17th century onwards, the theme of section two. By way of conclusion, the convergence of landscape appreciation and ruinophilia in early modern times is explained with recourse to the emergence of a new historical consciousness: the new interest in landscape, ruins, and their interplay was kindled by a growing awareness of the fact that these environmental features carried precious information about, and could even be seen as an embodiment of, the history of mankind and the earth.
Delving into Impossible Storyworlds of Terror: The Unnaturalness of Hassan Blasim’s Short Narrative Fiction
Authors: Biwu Shang
Published: June 2017

Many of Hassan Blasim’s short stories fall into a broad category of unnatural narrative. In line with the most recent scholarship on unnatural narratology, this article first discusses the unnatural worldmaking strategies adopted by Blasim that include dead narrators, conflicting events, and ontological metalepsis. Second, it analyzes a set of unnatural acts closely related to the characters’ death and their consequential corporeal impairments. Third, it examines the mentality of Blasim’s characters by focusing on a particular type of unnatural mind – the paranoid mind, which in radical cases involves two conflicting minds simultaneously emerging in one character. By resorting to unnatural narratives, Blasim makes his short stories anti-mimetically impossible but nightmarishly real, which not only generates effects of defamiliarity and horror but also forces us to ponder over what is now happening in the seemingly remote parts of the world and to raise our common concerns for human suffering.
Weakly Imposed Symmetry and Robust Preconditioners for Biot’s Consolidation Model
Authors: Bærland Trygve , Lee Jeonghun J. , Mardal Kent-Andre , Winther Ragnar
Published: June 2017

We discuss the construction of robust preconditioners for finite element approximations of Biot’s consolidation model in poroelasticity. More precisely, we study finite element methods based on generalizations of the Hellinger–Reissner principle of linear elasticity, where the stress tensor is one of the unknowns. The Biot model has a number of applications in science, medicine, and engineering. A challenge in many of these applications is that the model parameters range over several orders of magnitude. Therefore, discretization procedures which are well behaved with respect to such variations are needed. The focus of the present paper will be on the construction of preconditioners, such that the preconditioned discrete systems are well-conditioned with respect to variations of the model parameters as well as refinements of the discretization. As a byproduct, we also obtain preconditioners for linear elasticity that are robust in the incompressible limit.
Synthesis and characterization of polyvinylmethylsiloxanes by cationic polymerization using a solid green catalyst
Authors: Kherroub Djamal Eddine , Belbachir Mohammed , Lamouri Saad
Published: June 2017

The present work is devoted to the synthesis and characterization of vinylsiloxane polymers produced by the use of an activated natural catalyst known as Maghnite-H+. The cationic ring opening polymerization of pentavinylpentamethylcyclopentasiloxane (V5D5) made it possible to obtain the desired polymeric materials. Through this study, we have adapted a new strategy of synthesis of a siloxane polymer with relatively high molecular mass, using a solid initiator activated by sulfuric acid, which has enabled us to combine the ecological aspect of synthesis and the effectiveness of the catalyst in this kind of reaction. Structural [infrared (IR), proton and carbon nuclear magnetic resonance (1H NMR and13C NMR)], thermal differential scanning (DSC) and chromatographic (GPC) characterization methods have allowed the products obtained to be identified and their various properties to be focused on. The kinetic study was made to determine the order of the reaction. The proposed reaction mechanism shows the advantages of Maghnite-H+.
Wider den „Hauffen junger Schnautzhahnen“
Authors: Kraft Stephan
Published: June 2017

This paper retraces the specific conception of the ‘present’ as manifested in
„Himlische[s] beginen“, „trefliche[r] vortgang“
Authors: Bergengruen Maximilian
Published: June 2017

This essay asks the question of why, in 1647, Jesaias Rompler von Löwenhalt ousts Martin Opitz from the primal scene of German poetry, replacing him instead with Georg Rodolf Weckherlin. According to one hypothesis whose plausibility must be verified, the latter published his odes precisely in the year in which the Thirty Years’ War began, namely in 1618. Rompler, in turn, needed this temporal parallelism between war and literature in order to situate his present within the framework of an apocalyptic scenario. With the conclusion of the Thirty Years’ War, he expects a time of salvation which exhibits both political and literary features.
Blockierte Gegenwart?
Authors: Haas Claude
Published: June 2017

Prompted by the observation that the seventeenth-century unity of time is made to function in such a way as to override the theatrical audience’s perception of time, this contribution pursues the implications dramatic time and the potential representation of the present have in respect of poetics and the politics of sovereignty. The guiding question is whether the imagination of time as a homogenous continuum, formally implemented by the unity of time, was deliberately and effectively meant to preclude the representation and reflection of a temporality of the present even before its discovery in the eighteenth century.
Sad and lonely: body dissatisfaction among adolescent girls
Authors: Forste Renata , Potter Marina , Erickson Lance
Published: June 2017

Purpose

To further understand the association between body dissatisfaction and sadness/loneliness among adolescent girls, we examine how this association, as reported by pre-teen and adolescent girls, is mediated or moderated by the quality of peer and family relationships.

Methods

Our data are from the Health Behavior of School-Aged Children 2009–2010, a nationally representative survey of school-aged children in the US. We analyze a sample of 5658 girls in Grades 5 through 10. We utilize ordinary least squares (OLS) regression techniques and adjust for the complex sampling design. We explore how the link between body dissatisfaction and sadness/loneliness is mediated or moderated by family and peer relationships and also include controls for age, race, media exposure, and physical health.

Results

We find that body dissatisfaction is predictive of sadness/loneliness for girls at all grade levels and that the quality of peer and family relationships mediates 27%–38% of this association, particularly among early adolescent girls. Positive peer relationships also moderate or help mitigate the association between body dissatisfaction and sadness/loneliness among pre-teens.

Conclusion

Our findings underscore the association between body dissatisfaction and sadness/loneliness among early adolescent girls. In addition, our results highlight the importance of quality peer and family relationships in terms of how girls think about their bodies and respond emotionally to them. To evaluate feelings of sadness and loneliness among early adolescent girls, health care professionals need to consider not only body dissatisfaction but also the context of peer and family relationships.