bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of Two-Year Recurrence-Free Survival in Operable NSCLC Patients Using Radiomic Features from Intra- and Size-Variant Peri-Tumoral Regions on Chest CT Images
Authors: Lee Soomin , Jung Julip , Hong Helen , Kim Bong-Seog
Published: May 2022

To predict the two-year recurrence-free survival of patients with non-small cell lung cancer (NSCLC), we propose a prediction model using radiomic features of the inner and outer regions of the tumor. The intratumoral region and the peritumoral regions from the boundary to 3 cm were used to extract the radiomic features based on the intensity, texture, and shape features. Feature selection was performed to identify significant radiomic features to predict two-year recurrence-free survival, and patient classification was performed into recurrence and non-recurrence groups using SVM and random forest classifiers. The probability of two-year recurrence-free survival was estimated with the Kaplan–Meier curve. In the experiment, CT images of 217 non-small-cell lung cancer patients at stages I-IIIA who underwent surgical resection at the Veterans Health Service Medical Center (VHSMC) were used. Regarding the classification performance on whole tumors, the combined radiomic features for intratumoral and peritumoral regions of 6 mm and 9 mm showed improved performance (AUC 0.66, 0.66) compared to T stage and N stage (AUC 0.60), intratumoral (AUC 0.64) and peritumoral 6 mm and 9 mm classifiers (AUC 0.59, 0.62). In the assessment of the classification performance according to the tumor size, combined regions of 21 mm and 3 mm were significant when predicting outcomes compared to other regions of tumors under 3 cm (AUC 0.70) and 3 cm~5 cm (AUC 0.75), respectively. For tumors larger than 5 cm, the combined 3 mm region was significant in predictions compared to the other features (AUC 0.71). Through this experiment, it was confirmed that peritumoral and combined regions showed higher performance than the intratumoral region for tumors less than 5 cm in size and that intratumoral and combined regions showed more stable performance than the peritumoral region in tumors larger than 5 cm.
Feral Horses and Bison at Theodore Roosevelt National Park (North Dakota, United States) Exhibit Shifts in Behaviors during Drone Flights
Authors: Lenzi Javier , Felege Christopher J. , Newman Robert , McCann Blake , Ellis-Felege Susan N.
Published: May 2022

Drone use has been rapidly increasing in protected areas in North America, and potential impacts on terrestrial megafauna have been largely unstudied. We evaluated behavioral responses to drones on two terrestrial charismatic species, feral horse (Equus caballus) and bison (Bison bison), at Theodore Roosevelt National Park (North Dakota, United States) in 2018. Using a Trimble UX5 fixed-wing drone, we performed two flights at 120 m above ground level (AGL), one for each species, and recorded video footage of their behaviors prior to, during, and after the flight. Video footage was analyzed in periods of 10 s intervals, and the occurrence of a behavior was modeled in relation to the phase of the flights (prior, during, and after). Both species displayed behavioral responses to the presence of the fixed-wing drone. Horses increased feeding (p-value < 0.05), traveling (p-value < 0.05), and vigilance (p-value < 0.05) behaviors, and decreased resting (p-value < 0.05) and grooming (p-value < 0.05). Bison increased feeding (p-value < 0.05) and traveling (p-value < 0.05) and decreased resting (p-value < 0.05) and grooming (p-value < 0.05). Neither species displayed escape behaviors. Flying at 120 m AGL, the drone might have been perceived as low risk, which could possibly explain the absence of escape behaviors in both species. While we did not test physiological responses, our behavioral observations suggest that drone flights at the altitude we tested did not elicit escape responses, which have been observed in ground surveys or traditional low-level aerial surveys. Our results provide new insights for guidelines about drone use in conservation areas, such as the potential of drones for surveys of feral horses and bison with low levels of disturbance, and we further recommend the development of in situ guidelines in protected areas centered on place-based knowledge, besides existing standardized guidelines.
A New Entropy Function to Analyze Isentropic Processes of Ideal Gases with Variable Specific Heats
Authors: Çengel Yunus , Kanoğlu Mehmet
Published: May 2022

A new entropy function s+ is defined in terms of the existing entropy function s° and temperature as s+ = s° − R lnT to facilitate the analysis of isentropic processes of ideal gases with variable specific heats. The function s+ also makes it possible to calculate the entropy changes of ideal gases during processes when volume information is available instead of pressure information and the variation of specific heats with temperature is to be accounted for. The introduction of the function s+ eliminates the need to use the dimensionless isentropic functions relative pressure Pr and relative specific volume vr of ideal gases and to tabulate their values. The Pr and vr data are often confused with pressure and specific volume, with an adverse effect on the study of the second law of thermodynamics. The new s+ function nicely complements the existing s° function in entropy change calculations: the former is conveniently used when volume information is given while the latter is used when pressure information is available. Therefore, the introduction of the new entropy function s+ is expected to make a significant contribution to the thermodynamics education and research by streamlining entropy analysis of ideal gases.
If You Aim Higher Than You Expect, You Could Reach Higher Than You Dream: Leadership and Employee Performance
Authors: Khan Naveed Ahmad , Michalk Silke , Sarachuk Kirill , Javed Hafiz Ali
Published: May 2022

Leadership is about lifting a person’s vision, raising their productivity to higher standards and creating a personality beyond their usual capabilities. Our study examines the Pygmalion effect and leader-member exchange (LMX) on employee task performance via organizational commitment. The data was collected from 280 middle-level managers from top ten banks in Pakistan. This study offers three main contributions to the literature. First, our results discover a strong link between the Pygmalion effect, LMX and employees’ task performance through mediation of organizational commitment. Secondly, our study indicates that leaders should have higher quality relationships with employees and higher task performance expectations. Finally, most previous studies focused on leadership approaches or have been conducted in western developed countries. To our knowledge, this study is a unique contribution to the literature on leaders’ expectations in changing and diverse environments, as in underdeveloped countries like Pakistan.
The Influence of Students’ Self-Determination and Personal Achievement Goals in Learning and Engagement: A Mediation Model for Traditional and Nontraditional Students
Authors: Rothes Ana , Lemos Marina S. , Gonçalves Teresa
Published: May 2022

Self-determination theory (SDT) and achievement goal theory (AGT) assume that students’ level of self-determination and the goals they pursue in class are important factors in engagement and learning. The aims of this study were to: (1) investigate the links between the students’ types of motivation and personal achievement goals; (2) explore how these two sets of variables relate to learning, engagement, and exploring mediation effects; and (3) understand the specificities of nontraditional students vs. traditional students, regarding the way these variables relate to each other. The study used a sample of 361 Portuguese adult students, 138 traditional (younger than 25 years old), and 223 nontraditional (active adults returning to education, 25 or older). The instruments used were: Self-regulation Questionnaire—Learning, Personal Achievement Goal Orientations Scale, Adult Learning Strategies Evaluation Scale and Behavioral Engagement Questionnaire. Path analysis for the total sample revealed that mastery goals mediated the relationship between autonomous motivation and all educational outcomes, and performance-avoidance goals mediated the relationship between introjected regulation, external regulation, and behavioral and emotional engagement. Multiple-group path analysis revealed a much stronger pattern of relationships for nontraditional students, especially between the SDT and AGT variables. The theoretical and practical implications of the study are discussed.
Self-Assessment of Students of Geography Education and Primary Social and Science Teaching towards the Use of Digital (Geo-) Media for Written and Oral Argumentation
Authors: Wolff-Seidel Sebastian , Budke Alexandra
Published: May 2022

This article discusses possible challenges and potentials in the use of digital geomedia in the context of written and oral argumentation in higher education by examining the perspectives of students and lecturers, especially for the subjects of geography in general and primary school science. To this end, potentials and challenges, as well as competences that have to be promoted among pupils and students in dealing with digital geomedia in the context of written and oral argumentation are first discussed. In the following, we present the results of a mixed methods approach in which we surveyed student teachers with a questionnaire (n = 150) on the one hand and, on the other hand, reflected their view of the issue by analysing qualitative expert interviews (n = 17) with lecturers who teach at the same universities in the corresponding degree programmes. In this way we contextualise the student’s self-assessment in the respective location’s teacher training. Our results show that there is a high degree of commonality between lecturers and students with regard to the importance of argumentation with digital geomedia. At the same time, the assessment of the students’ abilities differs greatly; most students feel capable of dealing with these topics, while lecturers see deficits here.
Compact CMOS Wideband Instrumentation Amplifiers for Multi-Frequency Bioimpedance Measurement: A Design Procedure
Authors: Corbacho Israel , Carrillo Juan M. , Ausín José L. , Domínguez Miguel Á. , Pérez-Aloe Raquel , Duque-Carrillo Juan Francisco
Published: May 2022

The design of an instrumentation amplifier (IA), based on indirect current feedback and suited to electrical bioimpedance spectroscopy, is presented. The IA consists of two transconductors and a summing stage, featuring a single-stage configuration process that allows the maximum achievable bandwidth to be extended. The transconductors are linearized by means of resistive source degeneration, whereas the use of super source followers allows a reduction in the values of the source degeneration resistors. This fact leads to a decrease in the overall noise and the silicon area, thus resulting in a compact implementation. A thorough analysis of the proposed solution, accompanied by a design procedure and verified by means of electrical simulations, is also provided. Two versions of the IA, i.e., a single-ended (SE) and a pseudo-differential (PD) structure, were designed and fabricated using 180 nm CMOS technology to operate with a 1.8 V supply. The experimental results, including a BW of 5.2 MHz/8.0 MHz, a CMRR higher than 72 dB/80 dB, a DC current consumption of 139.0 μA/219.3 μA and a silicon area equal to 0.0173 mm2/0.0291 mm2 for the SE/PD implementation, validate the suitability of the approach.
An Ultra-Wideband Linear-to-Circular Polarization Converter Based on a Circular, Pie-Shaped Reflective Metasurface
Authors: Majeed Abdul , Zhang Jinling , Ashraf Muhammad Aqeel , Memon Saifullah , Mohammadani Khalid Hussain , Ishfaq Muhammad , Sun Mun
Published: May 2022

In this paper, we present an ultrawideband reflective metasurface with the properties of an LTC-PC, which is an orthotropic composition with two mutually orthogonal symmetric axes, v and u, and 45° rotation about the vertical y-axis. Based on the metasurface unit cell, it seems like a circular pie embedded with a rectangular patch. The converter can convert LP electromagnetic (EM) waves to CP waves over the bands from 20.18 GHz to 33.93 GHz, with a 3-dB AR bandwidth of up to 50.8% and a circular polarization wave that is RHCP (right hand CP). Moreover, the linear-to-circular PCR exceeds 98% in the frequency bands of 20–34 GHz. A comprehensive theoretical investigation was conducted to determine the fundamental cause of the LTC polarization conversion. The ∆φuv between two reflection coefficients at v- and u-polarized incidences is ±90°, which fully anticipates the axial ratio of the reflected wave. Any reflective metasurface can be used as an efficient LTC-PC if the ∆φuv is close to ±90°.
Effect of Lactic Acid Fermentation on Legume Protein Properties, a Review
Authors: Emkani Mehrsa , Oliete Bonastre , Saurel Rémi
Published: May 2022

Legume proteins have a promising future in the food industry due to their nutritional, environmental, and economic benefits. However, their application is still limited due to the presence of antinutritional and allergenic compounds, their poor technological properties, and their unpleasant sensory characteristics. Fermentation has been traditionally applied to counteract these inconveniences. At present, lactic acid fermentation of legumes is attracting the attention of researchers and industry in relation to the development of healthier, tasty, and technologically adapted products. Hence, we aimed to review the literature to shed light on the effect of lactic acid fermentation on legume protein composition and on their nutritional, functional, technological, and sensorial properties. The antimicrobial activity of lactic acid bacteria during legume fermentation was also considered. The heterogenicity of raw material composition (flour, concentrate, and isolate), the diversity of lactic acid bacteria (nutriment requirements, metabolic pathways, and enzyme production), and the numerous possible fermenting conditions (temperature, time, oxygen, and additional nutrients) offer an impressive range of possibilities with regard to fermented legume products. Systematic studies are required in order to determine the specific roles of the different factors. The optimal selection of these criteria will allow one to obtain high-quality fermented legume products. Fermentation is an attractive technology for the development of legume-based products that are able to satisfy consumers’ expectations from a nutritional, functional, technological, and sensory point of view.
Optimization of cis-9-Heptadecenoic Acid Production from the Oleaginous Yeast Yarrowia lipolytica
Authors: Al Sahyouni Wendy , El Kantar Sally , Khelfa Anissa , Park Young-Kyoung , Nicaud Jean-Marc , Louka Nicolas , Koubaa Mohamed
Published: May 2022

Odd-chain fatty acids (OCFA) have been studied for their therapeutic and nutritional properties, as well as for their potential use in the chemical industry for the production of biofuel. Genetic modification strategies have demonstrated an improved production of OCFA by oleaginous microorganisms. In this study, the production of OCFA-enriched lipids by fermentation using a genetically engineered Yarrowia lipolytica strain was investigated. The major fatty acid produced by this strain was the cis-9-heptadecenoic acid (C17:1). Its biosynthesis was optimized using a design of experiment strategy involving a central composite design. The optimal responses maximizing the cell density (optical density at 600 nm) and the C17:1 content (%) in lipids were found using 52.4 g/L sucrose, 26.9 g/L glycerol, 10.4 g/L sodium acetate, 5 g/L sodium propionate, and 4 g/L yeast extract. Under these conditions, in a 5 L scale bioreactor, the respective contents of lipids and C17:1 in culture medium were 2.52 ± 0.05 and 0.82 ± 0.01 g/L after 96 h fermentation. The results obtained in this work pave the way toward the process upscale of C17:1 and encourage its industrial production.
Exploring Use of the Metschnikowia pulcherrima Clade to Improve Properties of Fruit Wines
Authors: Kręgiel Dorota , Pawlikowska Ewelina , Antolak Hubert , Dziekońska-Kubczak Urszula , Pielech-Przybylska Katarzyna
Published: May 2022

Mixed fermentation using Saccharomyces cerevisiae and non-Saccharomyces yeasts as starter cultures is well known to improve the complexity of wines and accentuate their characteristics. This study examines the use of controlled mixed fermentations with the Metschnikowia pulcherrima clade, Saccharomyces cerevisiae Tokay, and non-conventional yeasts: Wickerhamomyces anomalus and Dekkera bruxellensis. We investigated the assimilation profiles, enzyme fingerprinting, and metabolic profiles of yeast species, both individually and in mixed systems. The chemical complexity of apple wines was improved using the M. pulcherrima clade as co-starters. M. pulcherrima with S. cerevisiae produced a wine with a lower ethanol content, similar glycerol level, and a higher level of volatilome. However, inoculation with the Dekkera and Wickerhamomyces strains may slightly reduce this effect. The final beneficial effect of co-fermentation with M. pulcherrima may also depend on the type of fruit must.
Electromagnetic Interference Shielding with Electrospun Nanofiber Mats—A Review of Production, Physical Properties and Performance
Authors: Blachowicz Tomasz , Hütten Andreas , Ehrmann Andrea
Published: May 2022

With a steadily increasing number of machines and devices producing electromagnetic radiation, especially, sensitive instruments as well as humans need to be shielded from electromagnetic interference (EMI). Since ideal shielding materials should be lightweight, flexible, drapable, thin and inexpensive, textile fabrics belong to the often-investigated candidates to meet these expectations. Especially, electrospun nanofiber mats are of significant interest since they can not only be produced relatively easily and cost efficiently, but they also enable the embedding of functional nanoparticles in addition to thermal or chemical post-treatments to reach the desired physical properties. This paper gives an overview of recent advances in nanofiber mats for EMI shielding, discussing their production, physical properties and typical characterization techniques.
Characterization of Wildfires and Harvesting Forest Disturbances and Recovery Using Landsat Time Series: A Case Study in Mediterranean Forests in Central Italy
Authors: Bonannella Carmelo , Chirici Gherardo , Travaglini Davide , Pecchi Matteo , Vangi Elia , D’Amico Giovanni , Giannetti Francesca
Published: May 2022

Large-scale forest monitoring benefits greatly from change detection analysis based on remote sensing data because it enables characterizing forest dynamics of disturbance and recovery by detecting both gradual and abrupt changes on Earth’s surface. In this study, two of the main disturbances occurring in Mediterranean forests, harvesting operations and forest fires, were analyzed through the analysis of Landsat Times Series images in a case study in Central Italy (Tuscany region). Disturbances were characterized based on their distinct temporal behaviors before and after the event: a period of 20 years (1999–2018) was used to extract and analyze at pixel level spectral trajectories for each disturbance and produce descriptive temporal trends of the phenomena. Recovery metrics were used to characterize both short- (5 years) and long-term aspects of recovery for harvested and burned areas. Spectral, recovery, and trend analysis metrics were then used with the Random Forest classifier to differentiate between the two disturbance classes and to investigate their potential as predictors. Among spectral bands, the Landsat SWIR 1 band proved the best to detect areas interested by harvesting, while forest fires were better detected by the SWIR 2 band; among spectral indices, the NBR scored as the best for both classes. On average, harvested areas recovered faster in both short- and long-term aspects and showed less variability in the magnitude of the disturbance event and recovery rate over time. This tendency is confirmed by the results of the classifier, which obtained an overall accuracy of 98.6%, and identified the mean of the post-disturbance values of the trend as the best predictor to differentiate between disturbances.
A Modified Mild-Slope Model for the Hydrodynamic Analysis of Arrays of Heaving WECs in Variable Bathymetry Regions
Authors: Bonovas Markos , Magkouris Alexandros , Belibassakis Kostas
Published: May 2022

A simplified model based on the Modified Mild-Slope Equation with inclusions is developed for modelling the scattering of waves from multiple heaving point absorbers arranged in an array in general bottom topography. The model is used, in conjunction with a 3D BEM, in order to estimate the parameters modelling the energy extraction of the devices using data obtained from the hydrodynamic responses and performance of the single floating WEC. Subsequently, the present model is used for specific examples to calculate the wave field and the hydrodynamic performance of arrays of heaving WECs in constant depth and variable bathymetry regions and illustrate the effect of bottom slope and variation on the calculated wave field in the domain and in the vicinity of the devices. The present simplified model provides a low-cost first estimation of the wave conditions in the domain, which could be exploited as a supporting tool for best arrangement and park design purposes.
Comparative Analysis of Volatile Compounds in Tieguanyin with Different Types Based on HS–SPME–GC–MS
Authors: Zeng Lin , Fu Yanqing , Huang Jinshui , Wang Jianren , Jin Shan , Yin Junfeng , Xu Yongquan
Published: May 2022

Tieguanyin (TGY) is one kind of oolong tea that is widely appreciated for its aroma and taste. To study the difference of volatile compounds among different types of TGY and other oolong teas, solid-phase microextraction–gas chromatography–mass spectrometry and chemometrics analysis were conducted in this experiment. Based on variable importance in projection > 1 and aroma character impact > 1, the contents of heptanal (1.60–2.79 μg/L), (E,E)-2,4-heptadienal (34.15–70.68 μg/L), (E)-2-octenal (1.57–2.94 μg/L), indole (48.44–122.21 μg/L), and (E)-nerolidol (32.64–96.63 μg/L) in TGY were higher than in other varieties. With the increase in tea fermentation, the total content of volatile compounds decreased slightly, mainly losing floral compounds. Heavily fermented tea contained a higher content of monoterpenoids, whereas low-fermentation tea contained higher contents of sesquiterpenes and indole, which could well distinguish the degree of TGY fermentation. Besides, the volatiles analysis of different grades of TGY showed that the special-grade tea contained more aroma compounds, mainly alcohols (28%). (E,E)-2,4-Heptadienal, (E)-2-octenal, benzeneacetaldehyde, and (E)-nerolidol were the key volatile compounds to distinguish different grades of TGY. The results obtained in this study could help enrich the theoretical basis of aroma substances in TGY.
Frozen Vegetable Processing Plants Can Harbour Diverse Listeria monocytogenes Populations: Identification of Critical Operations by WGS
Authors: Truchado Pilar , Gil María I. , Querido-Ferreira Ania Pino , Capón Cecilia López , Álvarez-Ordoñez Avelino , Allende Ana
Published: May 2022

Frozen vegetables have emerged as a concern due to their association with foodborne outbreaks such as the multi-country outbreak of Listeria monocytogenes serogroup IVb linked to frozen corn. The capacity of L. monocytogenes to colonize food-processing environments is well-known, making the bacteria a real problem for consumers. However, the significance of the processing environment in the contamination of frozen foods is not well established. This study aimed to identify potential contamination niches of L. monocytogenes in a frozen processing plant and characterize the recovered isolates. A frozen vegetable processing plant was monitored before cleaning activities. A total of 78 points were sampled, including frozen vegetables. Environmental samples belonged to food-contact surfaces (FCS); and non-food-contact surfaces (n-FCS). Positive L. monocytogenes samples were found in FCS (n = 4), n-FCS (n = 9), and the final product (n = 1). A whole-genome sequencing (WGS) analysis revealed two clusters belonging to serotypes 1/2a-3a and 1/2b-3b). The genetic characterization revealed the presence of four different sequence types previously detected in the food industry. The isolate obtained from the final product was the same as one isolate found in n-FCS. A multi-virulence-locus sequence typing (MVLST) analysis showed four different virulence types (VT). The results obtained highlight the relevant role that n-FCS such as floors and drains can play in spreading L. monocytogenes contamination to the final product.
Protective Effects of a Novel Probiotic Bifidobacterium pseudolongum on the Intestinal Barrier of Colitis Mice via Modulating the Pparγ/STAT3 Pathway and Intestinal Microbiota
Authors: Guo Weiling , Mao Bingyong , Cui Shumao , Tang Xin , Zhang Qiuxiang , Zhao Jianxin , Zhang Hao
Published: May 2022

Colitis has become a major health concern worldwide. The objective of the present study was to determine the probiotic influence of different strains of B. pseudolongum (Bp7 and Bp8) on alleviating colitis and to explore its possible potential mechanisms. Our results displayed that Bp7 and Bp8 intervention effectively reduced dextran sodium sulfate (DSS)-caused body weight loss and the release of several pro-inflammatory factors (interleukin (IL)-6, IL-1β, and tumor necrosis factor-α (TNF-α)) and increased the activities of antioxidant enzymes (T-AOC, SOD, and GSH) and the concentrations of tight junction proteins (occludin, claudin-1, and ZO-1). Moreover, Bp7 and Bp8 intervention drastically down-regulated the expression of colonic MyD88, NF-κB, iNOS and COX2 and drastically elevated the expression of colonic STAT3, Nrf2, and PPARγ. Gas chromatography-mass spectrometry results revealed that the cecal levels of isobutyric, butyric, and isovaleric acids were drastically increased in colitis mice intervened with Bp7 and Bp8. Moreover, 16S rRNA sequencing revealed that Bp7 and Bp8 intervention modulated the intestinal microbiota structure, particularly by enhancing the proportion of Eubacterium coprostanoligenes group, Marvinbryantia, Enterorhabdus, Faecalibaculum, Coriobacteriaceae UCG 002, Alistipes, and Bifidobacterium, which are relevant to the levels of cecal isobutyric acid, butyric acid, isovaleric acid, and inflammatory cytokines. Collectively, these findings suggest that Bp7 and Bp8 intervention alleviates the intestinal barrier function, possibly by blocking the secretion of proinflammatory cytokines, maintaining the intestinal physical barrier integrity, activating the PPARγ/STAT3 pathway, and modulating intestinal microbiota composition. Our study also suggested that B. pseudolongum is a promising probiotic for colitis treatment.
Dynamics of Changes in pH and the Contents of Free Sugars, Organic Acids and LAB in Button Mushrooms during Controlled Lactic Fermentation
Authors: Jabłońska-Ryś Ewa , Sławińska Aneta , Skrzypczak Katarzyna , Goral Karolina
Published: May 2022

The aim of the study was to assess changes in the basic quality parameters induced by controlled lactic fermentation of fruiting bodies of the button mushroom (Agaricus bisporus). Lactiplantibacillus plantarum 299v with documented probiotic properties and L. plantarum EK3, i.e., an isolate obtained from spontaneously fermented button mushrooms, were used as starter strains. The fruiting bodies of fresh, blanched, and fermented mushrooms were analyzed at different stages of the lactic fermentation process. The content of free sugars (high-performance liquid chromatography with charged aerosol detector method; HPLC-CAD) and organic acids (high-performance liquid chromatography with diode array detector method; HPLC-DAD) was determined both in the mushroom fruiting bodies and in the brine. Five free sugars (ribose, trehalose, sucrose, glucose, and fructose), mannitol, and six organic acids (lactic, malic, succinic, citric, acetic, and fumaric acids) were detected in the samples. Lactic acid dominated in the final products. The starter cultures exhibited varying degrees of utilization of available mushroom sugars and sucrose used as an additional substrate. Sucrose was utilized at a higher rate and in greater amounts by the L. plantarum EK3 isolate. This starter culture was characterized by a significantly higher final amount of produced lactic acid, a lower pH value, and higher numbers of LAB (lactic acid bacteria). These important quality parameters largely determine the stability of fermented products. Based on the analysis results and the high scores in the organoleptic evaluation of the fermented mushrooms, the L. plantarum EK3 isolate can be recommended as an appropriate starter culture for lactic fermentation of mushroom fruiting bodies.
Dry Heating of Cowpea Flour below Biopolymer Melting Temperatures Improves the Physical Properties of Bread Made from Climate-Resilient Crops
Authors: Renzetti Stefano , Heetesonne Ine , Ngadze Ruth T. , Linnemann Anita R.
Published: May 2022

Improving the technological functionality of climate-resilient crops (CRCs) to promote their use in staple foods, such as bread, is relevant to addressing food and nutrition security in Africa. Dry heating of cowpea flour (CPF) was studied as a simple technology to modulate CPF physicochemical properties in relation to bread applications. For this purpose, the melting behavior of cowpea starch and proteins in CPF was first studied and modeled using Flory–Huggins theory for polymer melting. Next, dry-heating conditions were investigated based on the predicted biopolymer melting transitions in CPF to be well below starch and protein melting. The pasting properties (i.e., peak viscosity, final viscosity, breakdown and setback) of CPF could be selectively modulated depending on temperature-time combinations without altering the thermal behavior (i.e., melting enthalpies) of CPF. Water-binding capacity and soluble solids decreased with the increased severity of the temperature-time combinations. Dry-heated CPF added to CRC-based bread significantly improved crumb texture. In particular, dry heating at 100 °C for 2 h provided bread with the highest crumb softness, cohesiveness and resilience. The positive effects on the crumb texture could be largely related to enhanced starch integrity, as indicated by a reduction in breakdown viscosity after treatment. Overall, dry heating of CPF under defined conditions is a promising technology for promoting the use of CPF as a techno-functional and protein-rich ingredient in bread-type products.
A New Method of Quantifying the Complexity of Fractal Networks
Authors: Babič Matej , Marinković Dragan , Kovačič Miha , Šter Branko , Calì Michele
Published: May 2022

There is a large body of research devoted to identifying the complexity of structures in networks. In the context of network theory, a complex network is a graph with nontrivial topological features—features that do not occur in simple networks, such as lattices or random graphs, but often occur in graphs modeling real systems. The study of complex networks is a young and active area of scientific research inspired largely by the empirical study of real-world networks, such as computer networks and logistic transport networks. Transport is of great importance for the economic and cultural cooperation of any country with other countries, the strengthening and development of the economic management system, and in solving social and economic problems. Provision of the territory with a well-developed transport system is one of the factors for attracting population and production, serving as an important advantage for locating productive forces and providing an integration effect. In this paper, we introduce a new method for quantifying the complexity of a network based on presenting the nodes of the network in Cartesian coordinates, converting to polar coordinates, and calculating the fractal dimension using the ReScaled ranged (R/S) method. Our results suggest that this approach can be used to determine complexity for any type of network that has fixed nodes, and it presents an application of this method in the public transport system.
Anthropic Principle and the Hubble-Lemaître Constant
Authors: Křížek Michal , Somer Lawrence
Published: May 2022

According to the weak formulation of the anthropic principle, all fundamental physical constants have just such values that they enabled the origin of life. In this survey paper, we demonstrate also that the current value of the Hubble–Lemaître constant essentially contributed to the existence of humankind. Life on Earth has existed continually for at least 3.5 Gyr, and this requires very stable conditions during this quite long time interval. Nevertheless, as the luminosity of the Sun increases, Earth has receded from the Sun by an appropriate speed such that it received an almost constant solar flux during the last 3.5 Gyr. We introduce several other examples illustrating that the solar system and also our galaxy expand by a speed comparable to the Hubble–Lemaître constant.
Reframing Monetization: Compensatory Practices and Generating a Hybrid Economy in Fanbinding Commissions
Authors: Kennedy Kimberly , Buchsbaum Shira
Published: May 2022

Monetization of fan-made crafts and texts remains a contentious issue in fandom. The existing literature documents fans’ rejections of explicitly for-profit, authorized spaces for fanfiction publication, such as Kindle Worlds and FanLib, but tenuous acceptance of crafts and practitioners who demonstrate adherence to gift culture principles. Fanbinding—the practice of binding fanworks into codex form—brings to the fore concerns of author permission, intellectual copyright, and compensation for artistic labor prevalent in arguments regarding fanfiction monetization. Our research draws from survey data collected from thirty-one fanbinders and examines how they justify their decision-making on taking commissions through perceptions of acceptable fannish behavior and definitions of gift culture. We found that binders who do take commissions overall reject an explicitly for-profit enterprise and instead reinvest funds back into their craft, strengthening binders and commissioners’ ability alike to contribute to the fandom gift economy. Here, binders offer a concentrated model for how to navigate competing concerns about fannish self-preservation, gift economy, and sustaining a costly craft, offering insights into how practitioners of other fancrafts might similarly navigate a third-space hybrid economy to justify compensation.
Hepatitis of Unknown Origin and Etiology (Acute Non HepA-E Hepatitis) among Children in 2021/2022: Review of the Current Findings
Authors: Sallam Malik , Mahafzah Azmi , Şahin Gülşen Özkaya ,   on behalf of ESCMID Study Group for Viral Hepatitis—(ESGVH)
Published: May 2022

Several clusters and individual cases of acute hepatitis have been reported in the US, Europe and recently in Asia and Central America since October 2021. A laboratory investigation of the common viral hepatitis agents (HAV, HBV, HCV, HDV and HEV) yielded negative results prompting the use of the term “acute non HepA-E hepatitis” to describe this condition. The cases were characterized by the manifestations of acute hepatitis (abdominal pain, vomiting, diarrhea, jaundice and very high levels of liver enzymes) affecting children with a median age of 3–4 years. The exact underlying etiology has not been revealed yet; however, a leading hypothesis is that an infectious agent is the culprit, underlying cause or a risk factor for acute non HepA-E hepatitis occurrence. So far, laboratory testing has shown the presence of the group F human adenovirus serotype 41 (HAdV-F41) in about three-fourths of the investigated cases. As of 13 May 2022, more than 450 cases were reported worldwide, the majority of which were in the UK (n = 176), the US (n = 109), 13 European countries (at least 103 cases) and in Argentina, Brazil, Canada, Costa Rica, Indonesia, Israel, Japan, Palestine, Panama, Singapore and South Korea. Vigilant surveillance and epidemiologic investigations to identify further cases are warranted to delineate the features of this emergent public health issue. The possible role of environmental and toxic agents including foodborne toxins should also be considered. Specific guidelines for identification of further cases are necessary, particularly in low-income settings where testing for adenoviruses is not considered routinely. A genetic analysis of HAdV-F41 isolates is recommended to assess the potential changes in the virus genome with subsequent possible altered virus behavior. Immunopathogenesis is another possibility that should be evaluated considering the lack of viral structures in liver biopsies of the affected children in the US.
Spirulina platensis Foliar Spraying Curcuma longa Has Improved Growth, Yield, and Curcuminoid Biosynthesis Gene Expression, as Well as Curcuminoid Accumulation
Authors: Al Dayel Munirah F. , El Sherif Fadia
Published: May 2022

The application of Spirulina platensis aqueous extract (SAE) in foliar spraying has been shown to promote plant growth and yield, as well as to modify the compositions of bioactive chemicals in various plant species. Curcuma longa is an antioxidant-rich medicinal herb that is used as a spice and culinary additive. The application of a natural plant growth enhancer, SAE, to C. longa plants was used in this study to test the effect of SAE for increasing active chemical production. The effects of SAE on the growth, yield and chemical composition of C. longa were investigated. SAE boosted the C. longa growth, yield and curcuminoid content, with SAE at 2 g/L having the most impact. The CURS-1, -2, -3 and DCS genes were found to be differentially elevated by SAE treatments in this investigation. When the plant was sprayed with SAE at 2 g/L, the curcuminoid content (bisdemethoxycurcumin, dimethoxycurcumin and curcumin) increased, which corresponded with the curcuminoid gene’s expression level.
Phytochemical Characterization of Twenty-Seven Peruvian Mashua (Tropaeolum tuberosum Ruíz & Pavón) Morphotypes and the Effect of Postharvest Methyl Jasmonate Application on the Accumulation of Antioxidants
Authors: Jacobo-Velázquez Daniel A. , Peña-Rojas Gilmar , Paredes-Avila Luis Ernesto , Andía-Ayme Vidalina , Torres-Contreras Ana Mariel , Herrera-Calderon Oscar
Published: May 2022

Tropaeolum tuberosum Ruíz and Pav. “Mashua” is a crop from the Andean region associated with preventing chronic degenerative diseases. This study evaluated the content of bioactive compounds (phenolics, glucosinolates, carotenoids, and ascorbic acid) in twenty-seven Peruvian mashua morphotypes. Furthermore, three morphotypes (MAC 067, MAC 092, and MAC 123) were selected to evaluate further the effect of methyl jasmonate (MeJA) on the accumulation of bioactive compounds. Phenolic content in the mashua morphotypes ranged from 2990.76 ± 273.5 mg/kg to 24,217.36 ± 1144 mg/kg; whereas carotenoids ranged from 12.8 ± 0.6 mg/kg to 85.8 ± 3.1 mg/kg. Moreover, total glucosinolate content ranged from 65 ± 11 mmol/kg to 1289 ± 65 mmol/kg. The different mashua morphotypes showed low levels of ascorbic acid (lower than 5 mg/kg) compared with other crops. Except for glucosinolates, MeJA application augmented the level of bioactive compounds, showing increases of up to 150.1%, 535.0%, and 542% for total phenolics, carotenoids, and ascorbic acid, respectively. Results indicated that mashua is an excellent source of phenolics and glucosinolates, whereas it contains adequate levels of carotenoids and low levels of vitamin C. MeJA application during postharvest represented a simple approach to increase the content of bioactive compounds in mashua.
Analysis of the Characteristics and Spatial Pattern of the Catering Industry in the Four Central Cities of the Yangtze River Delta
Authors: Wang Weiwu , Wang Shan , Chen Huan , Liu Lingjun , Fu Tianle , Yang Yuxin
Published: May 2022

The development of the catering industry in big cities is of great significance for countries to improve the quality of development and improve people’s living standards. In recent years, the urban catering industry has effectively promoted the process of urbanization, and it is significant to study the development characteristics and spatial distribution of the catering industry for the urban pattern. Taking the four central cities (Shanghai, Hangzhou, Nanjing, and Hefei) of China’s Yangtze River Delta (YRD) urban agglomeration as examples, first, the point-of-interest (POI) data of various catering facilities in the city’s main urban area were crawled from the Amap (AutoNavi map) open platform through Python. Second, for the first time, three quantitative indicators were constructed to characterize the development and urbanization of the urban catering industry, namely cuisine localization index (CLI), cuisine diversity index (CDI), and cuisine geographical preference index (CGPI). Third, the overall spatial characteristics of the catering industry in the four central cities and administrative districts were obtained using the methods of kernel density and spatial autocorrelation analysis. The spatial distribution of the catering industry development in each city is displayed through GIS visualization, and its influencing factors are discussed preliminarily through geographically weighted regression (GWR) model. The research shows that: (1) the four central cities in the YRD have formed core catering areas with different agglomeration levels. Different cuisines in the city have the characteristics of partial spatial overlap. (2) In the four central cities of the YRD, there is a significant positive spatial correlation between the catering industry as a whole and individuals. Hangzhou and Hefei have higher CLI (0.38), but the cuisine structure is relatively simple. The CLI of Shanghai and Nanjing is at a low level, but the overall cuisine structure is relatively balanced. (3) The catering industry in the four central cities has a high degree of agglomeration, a wide range of agglomeration, and many agglomeration points. Only Shanghai cuisine, Jiangsu and Zhejiang cuisine, Anhui cuisine, Fujian cuisine, Shandong cuisine, and Hunan cuisine have significant positive correlations in space, and the correlations weaken in turn. (4) The influence intensity of the influencing factors on CLI and CDI is in the order of degree of openness, regional economic level, market vitality, population concentration level, industrial structure. The spatial pattern of catering in a city is greatly affected by the regional economy and population density. This study can provide a reference for research on the spatial distribution of the catering industry in similar urban agglomerations around the world.
A Systematic Procedure for Utilization of Product Usage Information in Product Development
Authors: Deng Quan , Thoben Klaus-Dieter
Published: May 2022

Product design is crucial for product success. Many approaches can improve product design quality, such as concurrent engineering and design for X. This study focuses on applying product usage information (PUI) during product development. As emerging technologies become widespread, an enormous amount of product-related information is available in the middle of a product’s life, such as customer reviews, condition monitoring, and maintenance data. In recent years, the literature describes the application of data analytics technologies such as machine learning to promote the integration of PUI during product development. However, as of today, PUI is not efficiently exploited in product development. One of the critical issues to achieve this is identifying and integrating task-relevant PUI fit for purposes of different product development tasks. Nevertheless, preparing task-relevant PUI that fits different product development tasks is often ignored. This study addresses this research gap in preparing task-relevant PUI and rectifies the related shortcomings and challenges. By considering the context in which PUI is utilized, this paper presents a systematic procedure to help identify and specify developers’ information needs and propose relevant PUI fitting the actual information needs of their current product development task. We capitalize on an application scenario to demonstrate the applicability of the proposed approach.
Robot Crawler for Surveying Pipelines and Metal Structures of Complex Spatial Configuration
Authors: Pshenin Vladimir , Liagova Anastasia , Razin Alexander , Skorobogatov Alexander , Komarovsky Maxim
Published: May 2022

There is an obvious tendency towards increasing the information content of surveys of hard-to-reach objects at high altitudes through the use of remote-controlled robot crawlers. This can be explained by the reasonable desire of industrial objects owners to maintain their property: pipelines, containers, metal structures in operating technical condition, which contributes to reducing accident risks and increasing the economic efficiency of operation (optimization of repair planning, etc.) This paper presents the concept of a robotic device equipped with LIDAR and EMAT which can move over pipes from a diameter of 100 mm by using a special type of magnetic wheel. The robot uses convolutional neural networks to detect structural elements and classify their defects. The article contains information about tests held on a specially developed test rig. The results showed that the device could increase the information level of survey and reduce the labour intensity. In this work, we consider a prototype of the device which has not started mass operation at industrial facilities yet.
A Common Polymorphism in the MTHFD1 Gene Is a Modulator of Risk of Congenital Heart Disease
Authors: Karas Kuželički Nataša , Šmid Alenka , Vidmar Golja Maša , Kek Tina , Geršak Borut , Mazič Uroš , Mlinarič-Raščan Irena , Geršak Ksenija
Published: May 2022

Several environmental and genetic factors may influence the risk of congenital heart defects (CHDs), which can have a substantial impact on pediatric morbidity and mortality. We investigated the association of polymorphisms in the genes of the folate and methionine pathways with CHDs using different strategies: a case–control, mother–child pair design, and a family-based association study. The polymorphism rs2236225 in the MTHFD1 was confirmed as an important modulator of CHD risk in both, whereas polymorphisms in MTRR, FPGS, and SLC19A1 were identified as risk factors in only one of the models. A strong synergistic effect on the development of CHDs was detected for MTHFD1 polymorphism and a lack of maternal folate supplementation during early pregnancy. A common polymorphism in the MTHFD1 is a genetic risk factor for the development of CHD, especially in the absence of folate supplementation in early pregnancy.