bluuebunny/crossref_metadata_2025 huggingface dataset:
Okuma Kültürü Edinememiş Bireylere İlişkin Bir Anlatı Araştırması
Authors: ÇILDIR Burcu , ERGÜN İbadullah Hamza
Published: April 2021

Farklı sosyoekonomik düzeylerden gelen çocukların okuma ile ilgili yaşadıkları deneyimler nelerdir?” sorusu araştırmanın temel sorusunu oluşturmaktadır. Bu bağlamda üç farklı sosyoekonomik düzeyden seçilen toplam 3 erkek öğrenci ile derinlemesine görüşmeler yürütülmüş ve okumada yaşanan sorunların arka planında var olan toplumsal yapılar ortaya konmaya çalışılmıştır. Yöntem olarak anlatı araştırması seçilmiştir. Araştırmaya katılan 3 katılımcının okumaya ilişkin yaşadıkları kişisel deneyimleri, bakış açıları ve okumaya ilişkin sorunlara nasıl yaklaştıkları ortaya konulmaya çalışılmıştır. Üç farklı sosyoekonomik düzeyden gelen öğrencinin öykülerinde farklılaşan temalar olduğu gibi ortak noktalar olduğu da görülmüştür. Sosyal yapıların, bu benzer ve farklı noktaların biçimlenmesinde önemli roller oynadığı belirlenmiştir. Bu bağlamda söz konusu sosyal yapıların daha ayrıntılı incelenmesine dönük araştırmalar yürütülmesi önerilebilir.
Ara Tatilin Okuma Yazma Öğrenme Sürecine Yansımaları
Authors: KIROĞLU Kasım , TUT Edip , AYDOĞMUŞ Mücahit , TORUN Nurdan
Published: April 2021

Bu çalışmanın amacı, ara tatilin ilk okuma yazma öğrenme sürecine yansımalarını öğretmen görüşleri çerçevesinde ortaya koymaktır. Araştırmada temel nitel araştırma deseni kullanılmıştır. Araştırmanın çalışma grubunu 2019-2020 eğitim-öğretim yılında Samsun ilinin Atakum ilçesine bağlı ilkokullarda görev yapan 24 sınıf öğretmeni oluşturmaktadır. Çalışma grubu maksimum çeşitlilik örneklemesi yoluyla belirlenmiş ve Atakum’daki her ilkokuldan bir sınıf öğretmeni çalışmaya dahil edilmiştir. Araştırmada veriler, yarı yapılandırılmış görüşme formu aracılığıyla ve öğretmenlerle yapılan yüz yüze görüşmeler neticesinde elde edilmiştir. Elde edilen veriler içerik analizi yöntemiyle analiz edilmiştir. Araştırmada, öğretmenlerin görüşlerine göre ara tatilin öğrencilere duyuşsal boyutta etki ettiği ve bu durumun öğrencilerin ilk okuma yazma öğrenme süreçlerini etkilediği sonuçlarına ulaşılmıştır. Ayrıca ara tatilin ilk okuma yazma öğrenme sürecine etki etmesinde; okul tipi, ebeveyn desteği, teknolojik imkanlar, okul öncesi eğitim, tatil öncesi işlenen ses grubu sayısı gibi birtakım etmenlerin rol oynadığı sonuçlarına ulaşılmıştır.
Thinking through the Photo Essay: Observations for Medical Anthropology
Authors: Crowder Jerome W. , Cartwright Elizabeth
Published: April 2021

As photography becomes more prevalent in ethnographic research, scholars should more seriously consider the photo essay as a medium for sharing their work. In this Position Piece, we present guidelines for the creation of ethnographic photo essays for medical anthropology that do not simply combine image and text, but create a balance that allows words to provide context for the image(s) and images to reinforce or challenge the text. We feel there are three basic elements every photo essay must consider that are informed by the theory and practice of visual anthropology. While a solid background in visual anthropology is not necessary to produce a successful photo essay, being mindful of these three elements in relation to your work will help you develop a photo essay that combines the best of what both media offer your audience.
Диагностика диспозиционного оптимизма, валидность и надежность опросника ТДО-П
Authors: Гордеева Т.О. , Сычев О.А. , Осин Е.Н.
Published: April 2021

Под диспозиционным оптимизмом понимается когнитивная установка, включающая генерализованные ожидания относительно будущего или тенденцию индивида верить в то, что в будущем его ждет больше хороших событий, чем плохих. Согласно результатам исследований, показатели диспозиционного оптимизма связаны с меньшей депрессией, лучшим физическим здоровьем, психологическим благополучием, лучшими межличностными отношениями; основным постулируемым механизмом этих связей является влияние оптимизма на мотивацию, что проявляется в готовности оптимистов прилагать усилия, направленные на решение жизненных задач. В статье представлены результаты апробации теста диспозиционного оптимизма (ТДО-П) — русскоязычного аналога теста LOT-R М. Шейера, Ч. Карвера и М. Бриджеса, пересмотренной версии методики LOT. Апробация этой обновленной версии проводилась в двух исследованиях — на выборке студентов и аспирантов разных вузов (n = 406) и репрезентативной выборке россиян разных возрастов и профессий (n = 1509). Оба исследования свидетельствуют о высокой надежности опросника по внутренней согласованности (a Кронбаха составил 0.78). С помощью конфирматорного факторного анализа показана двухфакторная структура методики с ортогональными факторами оптимизма и стиля ответов. Валидность методики подтверждается существенными корреляциями с показателями психологического благополучия и умеренными, но статистически значимыми корреляциями с показателями оптимистического мышления. В поль­­зу конструктной валидности ТДО-П также свидетельствуют корреляции с показателями саморегуляции, надеждой и жизнестойкостью. В статье представлены подробные данные о связи оптимизма с социально-демографическими характеристиками: полом, возрастом, уровнем образования. На основе полученных данных приведены ориентировочные статистические нормы. Методика может быть использована исследователями и практиками для получения данных о выраженности диспозиционного оптимизма как личностной черты, описывающей генерализованные ожидания относительно будущего.
Processing a Viral Metagenome Using iVirus v2
Authors: Bolduc Benjamin
Published: April 2021

A collection of protocols designed to guide the user in processing a viral metagenome from raw sequence data to assembly, and subsequent analysis. The user usesactual reads fromOcean Sampling Day (2014)and processes them entirely within Cyverse, a NSF-supported cyberinfrastructure.
Impact of Structured Lifestyle Intervention Program with Antigravity Exercise on Glycemic Control in People with T2DM
Authors:   Senior Assistant Surgeon, Government Head Quarters Hospital, Tirupur, Tamil Nadu, India, MuthuVel Dr. T , Karthikeyan Dr. S. ,   Assistant Professor, Department of Orthopedics, Sivagangai Medical College, Sivagangai, Tamil Nadu, India
Published: April 2021

Introduction: Diabetes mellitus (DM) is a common endocrinopathy and assumes significance for itsability to adversely affect the various internal organs. It can also derail the immune system of theaffected. Abnormal insulin secretion and/or utilization, leads to hyperglycemia which has adverseeffects on the heart, blood vessels, kidney, nervous system, eye and skin. To assess theeffectiveness of structured vs unstructured lifestyle modification therapy in glycemic control (changein HbA1c value from baseline to the end of the intervention) in people with T2DM. Methods: Thisstudy is a randomized, controlled, parallel-group study with lifestyle modifications as intervention.Study was conducted for between Feb 2019 to Dec 2019 in the Department of General Medicine,Government Headquarters hospital, Tirupur. Results: A total of 70 participants, 30 to 60-year-old,diagnosed with T2DM for more than a year with HbA1c levels > 6.5 %, on a background of oralantidiabetic agents were enrolled after obtaining the informed consent. Mean age of Group A andGroup B found 49.17±7.42 and 51.92±9.1. Male were predominant in the study. Mean weight, MeanFBS, Mean PPBS and Mean HbA1c are statistically significant between groups (p<0.05) at baseline.Group B with unstructured physical activity with walking, was beneficial (HbA1c reduction 0.30 %; p= 0.024), but no significant decline in HbA1c, whereas, in Group A with structured antigravityexercise, is associated with a significant HbA1c decline of 1.2 %. (p = 0.07865). Conclusion:Structured antigravity exercise training was more efficacious than unstructured physical activity inachieving controlled HbA1c levels. Although both structured and unstructured training providebenefits, only the former was associated with significant reductions in HbA1c levels. Hence, T2DMpatients should be advised to follow structured antigravity exercise training & focused dietaryintervention program.
PEDAGOGIA COMO CIÊNCIA DA EDUCAÇÃO: DIMENSÕES EPISTEMOLÓGICAS E CONCEITUAIS
Authors: Moreira Jefferson da Silva , Nunes Mascarenhas Aline Daiane
Published: April 2021

Este texto, de natureza ensaística, tece provocações sobre a problemática subjacente à base epistemológica da Pedagogia, aqui concebida como um campo de conhecimento, cujo objeto de análise é o fenômeno educativo. Assim, delineamos como objetivo geral deste estudo explorar na literatura o percurso histórico que subsidia a defesa da pedagogia enquanto área de conhecimento e seus pressupostos epistemológicos. Com efeito, a seguinte questão norteadora subsidiou nossas reflexões: quais discussões de natureza epistemológica estão subjacentes às perspectivas teóricas que concebem a Pedagogia enquanto área de conhecimento, em oposição às recomendações oficialmente propostas pelas Diretrizes Curriculares Nacionais (DCNP 2006), que a preconiza como um curso de formação de professores? O ensaio está fundamentado teoricamente nas reflexões de Saviani (2009); Libâneo (2010); Franco (2008); Pimenta (2010); Pinto (2011, 2017),  que convergem em defender a Pedagogia por ser a Teoria ou a Ciência da Educação. Conclui-se apontando a necessidade de compreensão mais densa sobre a Pedagogia enquanto área de conhecimento, com estatuto epistemológico próprio, contrapondo-nos, desse modo, às recomendações oficialmente propostas pelas DCNP (2006), que a reduz a uma licenciatura para formação de professores.
CURSO DE PEDAGOGIA ALLÍ E AQUI: ESTUDO COMPARADO ENTRE OS CONTEXTOS ESPANHOL E BRASILEIRO.
Authors: Ferreira Liliana Soares , Pedrera Ana Maria Montero
Published: April 2021

Esse artigo tem como objetivo argumentar comparativamente sobre os cursos de Pedagogia na Espanha e no Brasil, destacando a historicidade, o modo como se organizam, a proposta curricular, as características previstas para os egressos(as) e, ainda, destacar as convergências e diferenças. Realizou-se estudo comparado. A educação comparada consiste então em comparar, mas ir além, também entender por que a educação se constituiu nas diferentes culturas, como se organiza para responder às demandas sociais. Analisou-se o Curso de Pedagogia, inserido nos contextos de produção espanhol e brasileiro, tendo por base sua historicidade, objetivos, características, proposta curricular e o trabalho dos egressos. Observou-se diferenciação quanto à abrangência das propostas, quanto ao grau, bacharelado e licenciatura, e quanto ao sentido de Pedagogia impresso no Curso.
INDIGENOUS SCHOOL EDUCATION AND THE KRAHO SCHOOLS
Authors: Ribeiro Meireles José Manuel
Published: April 2021

O texto a ser publicado refere-se à investigação da educação escolar entre os Krahô, grupo indígena do Tocantins. Especificamente, foi investigada a situação de duas aldeias com escola secundária, localizadas nas maiores comunidades daquele povo e denominadas Pedra Branca e Manoel Alves. A meta é entender a influência da escola modificando a identidade krahô, o cotidiano das aldeias e a cultura krahô. Ficou claro através da pesquisa de campo a existência da relação entre a educação escolar e o status político alcançado pelos jovens graduados na escola secundária.
Causes of drug resistance and glioblastoma relapses
Authors: Mitrofanov A. A. , Naskhletashvili D. R. , Aleshin V. A. , Belov D. M. , Bekyashev A. Kh. , Karakhan V. B. , Sevyan N. V. , Prozorenko E. V. , Roshchina K. E.
Published: April 2021

Glioblastoma multiform^ is one of the most aggressive malignancies, wich standard of treatment not changed over the past decade, and the average life expectancy from diagnosis to death does not exceed two years in the most optimistic trials. The review examines the features of the glioblastoma microenvironment, its genetic heterogeneity, the development of recurrent glioblastoma, the formation of drug resistance, the influence of the blood-brain barrier and the brain lymphatic system on the development of immunotherapy and targeted therapy. Molecular subgroups of glioblastomas with an assumed prognostic value were analyzed. It was determined that numerous relationships between glioblastoma cells and the microenvironment are aimed at ensuring tumor progression, and also cause a state of reduced effector function of T cells. Data on the development of future molecular-targeted therapies for four types of cancer cells based on their different properties and response to therapy are summarized: primary GSC, RISC cells, and proliferating and postmitotic non-GSC fractions. The penetration of blood-brain barrier with chemotherapeutic drugs and antibodies currently remains the main limitation in the treatment of glioblastoma. The resulting analysis of the causes is reduced to the following conclusions. A detailed understanding of the evolutionary dynamics of tumor progression can provide insight into the related molecular and genetic mechanisms underlying glioblastoma recurrence. The most promising methods of treatment for glioblastoma are combined therapy using immune checkpoint inhibitors in combination with new treatment methods -vaccine therapy, CAR-T-cell therapy and viral therapy. A deeper study of the mechanisms of drug resistance and acquisition resistance, biology and subcloning clonal populations of glioblastoma and its microenvironment, with active consideration of combined trips to the treatment will increase the survival rate of patients, and may lead to stable remission of the disease.
Mutation profile of the tall cell variant of papillary thyroid carcinoma: analysis of 5 cases using wide-panel next-generation sequencing
Authors: Plaksa I. L. , Savchuk M. R. , Shved N. V. , Savelov N. A. , Khmelkova D. N. , Isaev А. A. , Deev R. V.
Published: April 2021

The study objective is to analyze the mutation profile of the tall cell variant (TCV) of papillary thyroid carcinoma (PTC).

Materials and methods. The main inclusion criteria according to the WHO classification (2017) was PTC composed of at least 30 % of tall cells. Genetic examination was conducted using the FoundationOne CDx assay (USA) with median depth of coverage of >500x. This study included 5 patients (1 man and 4 women) with a mean age of 52.6 years (range: 48-56 years). The tumor size varied between 0.4 x 0.5 cm and 11.0 x 9.0 cm. All patients have undergone surgical treatment: hemithyroidectomy for patient No. 1 with a small tumor (pT1b); thyroidectomy for patient No. 2 (pT3b); extensive thyroidectomy with the removal of paratracheal tissue for patients No. 3, 4, and 5 (No. 3 - pT3bN0; No. 4 - pT3bN1b; No. 5 - pT3bN1b). Three out of the five patients also had adenomatous goiter. The mean follow-up time was 3.4 to 5.2 years.

Results. Tumors in all patients were characterized by low mutational load (0 to 4 mutations per 1 million nucleotides (megabase)) and no microsatellite instability. All study participants were found to have p.V600E mutation in the BRAF gene; two patients had c.-124C>T mutation in the promoter region of the TERT gene. All patients carried mutations with unknown clinical significance: p.V562I in the EPHB1 gene (in 2 patients); mutations in the genes AR, CREBBP, EP300, ERCC4, FLT1, IKBKE, JAK2, MAF, MLL2, MST1R, MYC, MYCL1, NTRK2, TSC2 (each mutation registered in one patient). One individual with the largest tumor and the most aggressive disease was found to have amplifications of the BTG2, MAP3K1, SMAD2, and TBX3 genes.

Conclusion. In 5 patients analyzed in this study, the mutation profile of TCV PTC was characterized by low mutational load, no microsatellite instability, and presence of p.V600E mutation in the BRAF gene in all cases. Some patients also had c.-124C>T mutation in the TERT gene and p.V562I mutation in the EPHB1 gene.
Characteristics and Functional Purpose of the System of Criminal Law Rules Providing Protection of Military Law and Order
Authors: Bodaevsky V. P.
Published: April 2021

Based on the provisions of the general theory of systems and the theory of law, the author of the paper, taking into account philosophical objective attitudes, argues that, despite the fact that the law-maker refers legal norms ensuring protection of the military law and order to differnt institutions of criminal law, they must be regarded as a system that is a holistic, relatively independent, component institution of criminal law. The author argues that this system in its type belongs to open systems, since even in the conditions of partial determination in the structure of the criminal law it is able to react to the external conditions through available points of contact. Given various challenges and threats to the military law and order at the beginning, this system, having transformed them, allows in the end to provide prevention of military crime and criminal law protection of the military law and order. It is stated that this system is based on a variety of external and internal relations between its elements and larger formations. Among such connections the author enumerates genetic relations (spawn relations), coordination, subordination and structural intra-system connections that together support homeostasis of the systems of military-criminal norms, i.e. ensure its existence and functioning. The structure of this system depends on its subject and functional purpose, namely, providing criminal legal protection of military law and order in peacetime and wartime. The analysis of the integrative properties of this system, its typological characteristics and subject and functional purpose makes it possible to conclude that the system of military and criminal law rules constitute a sub-brunch of criminal law.
Digital society: A sociocultural analysis of the digital footprint
Authors: Listvina Evgeniia V.
Published: April 2021

The article analyzes the digital footprint as a phenomenon of the emerging digital space and digital society. The purpose of the article is to study the digital footprint as a multi-layered phenomenon with multi-faceted features that manifest themselves in various spheres of life of an individual and society. The author considers three layers that characterize the digital footprint from the standpoint of its impact on the sociocultural component of society, the specifics of its formation, and its impact on the development and existence of the individual in the modern transformational era. The study highlights the positive (related to the possibilities of realizing personal potential) and negative (suggesting a distortion of the socio-cultural space) aspects of the functioning of the digital footprint. Conclusions are made about the need for a philosophical study of the phenomenon of the digital footprint in connection with its increasing importance in the formation of a new volume layer of socio-cultural space that creates qualitatively different forms of social existence.
Methodological and socio-philosophical aspects of nomadology: A critical view through the prism of the philosophy of everyday language
Authors: Stepanov Ivan V.
Published: April 2021

The works of Gilles Deleuze and Felix Guattari are known to be the most popular ones in Europe and Russia among the works of post-structuralist philosophers of the second half of the XX century. In a project called nomadology, Deleuze and Guattari attempted to update questions about the relationship between philosophy and science, philosophy and religion, philosophy and politics, politics and war. The article analyzes the ways of setting and solving these issues. The methodological basis of the analysis serves the principles developed by Ludwig Wittgenstein in the framework of the philosophy of everyday language.
Jihad: From the word to the cultural universal
Authors: Kuzmenko Nataliya S.
Published: April 2021

The article analyzes the widespread interpretations of the concept of jihad as a holy war, a war with the infidels, as well as lesser known ones struggle, diligence, effort. Its ambiguity is determined by the impossibility of an unambiguous definition of jihad. The author has made an attempt to reconstruct and group approaches to the definition of jihad, on the basis of which jihad is proposed to be understood as an idea that is implemented in the practices of various levels, depending on the sociocultural context. The connotative constant highlighted by the author in the variety of meanings of jihad effort (effort in the way) is proposed to be recognized as a cultural universal that can be found in different cultures and in practices.
Dance of the language: Primordial cultural modalities in the light of metaphor theory
Authors: Malyshev Vladislav B.
Published: April 2021

The article analyzes the relationship between the conceptual field of metaphor and the primordial cultural modalities in the context of the problem of transcendent instances. Metaphor, mimesis, and poetry as three types of modeling the reality of culture can be correlated in the plane of language representation of the world. The dance of language is the top species of mimetic evolution, whereas metaphor is the key to understanding the mechanism of mimesis in art and culture (I.-G. Herder, F. Nietzsche). The discourse of the primordial cultural modalities in language is clothed in certain images, in certain mimetic forms, in the dance of language. Metaphor is the key to understanding the primordial cultural modalities. It is in the dance of language which a person finds wholeness of being.
1-desamino-8-D-arginin-vasopressin, DDAVP, increases the content of brain-derived neurotrophic factor (BDNF) in blood plasma of rats in model of post-traumatic stress disorder
Authors: Belokoskova Svetlana G. , Krytskaya Darya V. , Beznin Gleb V. , Karpenko Marina N. , Tsikunov Sergey G.
Published: April 2021

Objective. We aimed to analyze the effect of an agonist of vasopressin type 2 receptors, 1-desamino-8-D-arginine-vasopressin, DDAVP, on the content of the brain neurotrophic factor, BDNF, in the hippocampus and blood plasma of rats exposed to vital stress.
Material and methods. The study carried out on female Wistar rats divided into 4 groups: first group included control animals, 2 those who received DDAVP intranasally in small doses (once 2 ∙ 109 g, course 20 ∙ 109 g), 3 those who exposed to the stress of a threat to life caused by the experience of the death of a partner from the actions of a tiger python, 4 those who exposed to stress and received DDAVP. BDNF concentration in samples was measured by immunohistochemical method.
Results. An increase in the content of BDNF in blood plasma in rats exposed to acute psychogenic stress and received DDAVP therapy was revealed on the tenth day after stress. There was no effect of stress, DDAVP, or their combined effect on the BDNF content in the homogenate of hippocampal tissues.
Conclusion. The results of this pilot study indicate that DDAVP has a modulatory effect on BDNF metabolism in rats exposed to vital stress. It is assumed that an increase in the level of neurotrophin in the blood of rats reflects the activation of compensatory processes.
Community Participation for Transition- Aged Youth with Intellectual and Developmental Disabilities: A Systematic Review
Authors: Santiago Perez Tania , Crowe Brandi
Published: April 2021

All people, including individuals with intellectual and developmental disabilities (IDD) deserve to actively participate in the community in which they live. For transition aged-youth (TAY) with IDD, attaining successful community participation can be difficult. The purpose of this systematic review was to identify and synthesize the literature specific to recreational therapy interventions in the U.S. aimed at improving community participation among TAY with IDD. Literature specific to two domains of community participation were explored: a) interpersonal life; and b) community, civic and social life. Eight studies were reviewed using a thematic synthesis approach to identify common themes across studies. Findings revealed three themes: 1) programs with collaboration and community supports, 2) leisure education, and 3) social skills training. Facilitators, barriers, and promising approaches regarding community participation of TAY with IDD are described. Implications and limitations of the current literature are also addressed.
Patient-Reported Outcome Measures: A Resource for Recreational Therapists
Authors: McCormick Bryan , Austin David
Published: April 2021

To our knowledge, information on patient-reported outcomes (PROs) and patient-reported outcome measures (PROMs) has not appeared in the literature of recreational therapy. This article provides an introduction to PROs and PROMs so recreational therapists may understand them and see their possible applications within recreational therapy. In this article, PROs and PROMs are described. Specific examples of PROMs, and resources for accessing them are provided. Discussion on the value of PROs in the enhancement of client care, challenges to the use of PROMs, and the relevance of PROMS to recreational therapy practice and research follows. It is concluded that the use of PROMs is an emerging approach that recreational therapists need to explore.
Majors e hegemonia no mercado fonográfico brasileiro
Authors: Barreto Mariana
Published: April 2021

Este artigo analisa o funcionamento das gravadoras de discos transnacionais que operam no mercado fonográfico brasileiro, a partir do estabelecimento do disco compacto como suporte padrão para a reprodução e comercialização de música gravada. Partindo da hipótese de que em tempos de globalização da economia e mundialização da cultura, este mercado se comporta e se modula de modo diverso, investiga-se quais são as características estruturais de tais transformações e como agem os diferentes agentes sociais que disputam este espaço. Considerando a configuração destas gravadoras enquanto majors, explora-se, ainda, como se organizam frente aos desafios impostos pela economia global, de que forma conservam, ou não, os mecanismos de reprodução deste campo, no qual elas mesmas são fundadoras dos seus princípios de construção.
The Commonwealth of Independent States: Thirty Years Together
Authors: Malyshev D.
Published: April 2021

The article analyzes the main key events in the development of the thirty-year history of the Commonwealth of Independent States (CIS) as the main structure operating in the post-Soviet space. The main stages of the formation of the CIS as a full-fledged international organization are shown; the characteristics of its structure and statutory bodies are given. Special attention is paid to the essential aspects of the development of the CIS in 2020–2021, as well as the current state of this organization, the direction of its activities in the context of overcoming the negative consequences of the coronavirus pandemic. The possible alternatives for the development of the Commonwealth in the near future have been predicted.
The Design of Tunable Photonic Crystal Biosensor With the Integration of PN Phase Shifter Using PIC Design Approach
Authors: Haron Mohamad Hazwan , Berhanuddin Dilla Duryha , Shaari Sahbudin , Yeop Majlis Burhanuddin , Md Zain Ahmad Rifqi
Published: April 2021

Silicon-based photonic integrated circuit (PIC) is a research focus in producing high-density photonics. One of the potential applications of silicon PIC is the sensing and measurement system. In this work, we use the one-dimensional photonic crystal (1D-PhC) cavity design which and utilize it at the PIC level design. The 1D PhC design used as the compact model has the same characteristics as experimentally demonstrated in previous works. The compact model is made from the S-parameter extraction of the 1D-PhC device which is done by using Lumerical FDTD software. The PIC design integrates the 1D-PhC device as a sensing component with a PN-phase shifter (PN-PS) to function as a refractive index (RI) sensor calibration or tuning circuit. A custom design of PN-PS device is used by simulating and extracting the bias voltage-effective index (bias-Neff) data by using Lumerical DEVICE and MODE into the circuit simulator. The circuit-level simulation is done by using Lumerical Interconnect software. Finally, we show the GDSII layout design of the 1D-PhC based photonic sensor calibration circuit with an analysis of generic silicon PIC design rules. The designed PIC is applicable for the bio-sensing applications and photonic SOC component. This work also shows the promise of PIC design approach for further PIC development.
Leafy Stems of Phagnalon saxatile subsp. saxatile from Algeria as a Source of Chlorogenic Acids and Flavonoids with Antioxidant Activity: Characterization and Quantification Using UPLC-DAD-ESI-MSn
Authors: Haddouchi Farah , Chaouche Tarik Mohammed , Ksouri Riadh , Larbat Romain
Published: April 2021

Phagnalon saxatile subsp. saxatileest une espèce sauvage très répandue en Algérie qui est utilisée à des fins médicinales comme analgésique et anticholestérolémique. Cependant, les informations sur son contenu phytochimique sont encore rares. L'objectif de cette étude était d'identifier et de quantifier les composés phénoliques de différents extraits de ses tiges feuillues. A cet effet, les effets de quatre solvants d'extraction ont été étudiés sur la teneur en composés phénoliques et l'activité antioxydante de cette plante. Les extraits préparés avec des solvants polaires (méthanol et eau) contenaient des quantités plus élevées de composés phénoliques et présentaient une meilleure activité antioxydante que les extraits avec des solvants apolaires (hexane, dichlorométhane). L'extrait méthanolique, le plus riche en phénoliques totaux et en flavonoïdes totaux, avait une activité antioxydante significative au regard de la capacité de piégeage du DPPH ° (IC50 de 5,47 µg / mL), Capacité de piégeage ABTS (CI50 de 63,77 µg / mL) et inhibition de l'oxydation de l'acide linoléique (CI50 de 22,71 µg / mL), par rapport aux antioxydants synthétiques. Les acides chlorogéniques et quelques flavonoïdes ont été identifiés et quantifiés par UPLC-DAD-MSn. Les isomères des acides di-O-caféoylquiniques étaient les composés phénoliques les plus concentrés (25,4 mg / g DW) dans l'extrait méthanolique.
ROS and NO Phytomelatonin-Induced Signaling Mechanisms Under Metal Toxicity in Plants: A Review
Authors: Pardo-Hernández Miriam , Lopez-Delacalle Maria , Marti-Guillen Jose M , Martinez-Lorente Sara E , Rivero Rosa M
Published: April 2021

Metal toxicity in soils, along with water runoff, are increasing environmental problems that affect agriculture directly and, in turn, human health. In light of finding a suitable and urgent solution, research on plant treatments with specific compounds that can help mitigate these effects has increased, and thus the exogenous application of melatonin (MET) and its role in alleviating the negative effects of metal toxicity in plants, have become more important in the last few years. MET is an important plant-related response molecule involved in growth, development, and reproduction, and in the induction of different stress-related key factors in plants. It has been shown that MET plays a protective role against the toxic effects induced by different metals (Pb, Cd, Cu, Zn, B, Al, V, Ni, La, As, and Cr) by regulating both the enzymatic and non-enzymatic antioxidant plant defense systems. In addition, MET interacts with many other signaling molecules, such as reactive oxygen species (ROS) and nitric oxide (NO), and participates in a wide variety of physiological reactions. Furthermore, MET treatment enhances osmoregulation and photosynthetic efficiency and increases the concentration of other important antioxidants such as phenolic compounds, flavonoids, polyamines (PAs), and carotenoid compounds. Some recent studies have shown that MET appeared to be involved in the regulation of metal transport in plants, and lastly, various studies have confirmed that MET significantly upregulated stress tolerance-related genes. Despite all the knowledge acquired over the years, there is still more to know about how MET is involved in the metal toxicity tolerance of plants.
Neuroprotective ability of Apocynin Loaded Nanoparticles (APO-NPs) as NADPH Oxidase (NOX)-Mediated ROS Modulator for Hydrogen Peroxide-Induced Oxidative Neuronal Injuries
Authors: Singh Manisha , Agarwal Shriya , Tyagi Vandana , Agarwal Vinayak , Pancham Pranav , Kaur Ramneek , Kaur Harleen , Tiwari Raj Kumar
Published: April 2021

Apocynin (APO) is a known multi enzymatic complexed compound, employed as a viable NADPH oxidase (NOX) inhibitor, extensively used in both traditional and modern-day therapeutic strategies to combat neuronal disorders. However, its therapeutic efficacy is limited by its lower solubility and lesser bioavailability thus, a suitable nanocarrier system to overcome such limitations is needed. Present study is designed to fabricate APO loaded polymeric nanoparticles (APO-NPs) to enhance its therapeutic efficacy and sustainability in the biological system. The optimized APO NPs in the study exhibited 103.6 ± 6.8 nm and -13.7 ± 0.43 mV of particle size and zeta potential respectively along with further confirmation by TEM. Also, the antioxidant (AO) abilities quantified by DPPH and Nitric oxide scavenging assays exhibited comparatively higher AO potential of APO-NPs than APO alone. In-vitro release profile displayed a linear diffusion pattern of zero order kinetics for APO–NPs, followed by its cytotoxicity evaluation on PC12 cell line that revealed minimal toxicity with higher cell viability, even after treatment with stress inducer (H2O2). The stability of APO-NPs checked after six months showed minimal AO decline in comparison to APO only, indicating that designed nano formulation has enhanced therapeutic efficacy for modulating NOX mediated ROS generation.
Association between Bone Biomarkers Osteoactivin and OPG with Plasma Levels of Irisin and Meteorin-like Protein in People with T2D and Obesity
Authors: Cherian Preethi , Al-Khairi Irina , Jamal Mohammad , Al-Sabah Suleiman , Ali Hamad , Dsouza Carol , Shawaf Eman Al , Al-Ali Waleed , Al-khaledi Ghanim , Al-Mulla Fahd , Abu-Farha Mohamed , Abubaker Jehad
Published: April 2021

The musculoskeletal system consisting of bones and muscles have been recognized as endocrine organs secreting hormones that are involved in regulating metabolic and inflammatory pathways. Obesity and type 2 diabetes (T2D) are associated with several musculoskeletal system complications. We hypothesized that an interaction exists between adipomyokines namely, irisin and METRNL, and various bone markers in individuals with obesity and T2D. A total of 228 individuals were enrolled in this study, including 124 non-diabetic and 104 T2D. A Multiplex assay was used to assess the level of various bone markers namely Osteoactivin, Syndecan, osteoprotegerin (OPG) and osteonectin/SPARC. Our data shows elevated levels of Osteoactivin, Syndecan, OPG and SPARC in T2D as compared to non-T2D individuals (p ≤ 0.05). Using Spearman’s correlation, irisin was positively correlated only with Osteoactivin and OPG (p < 0.05). Similarly, a positive association was observed between METRNL and Osteoactivin (p < 0.05). The strong positive association shown in our study between irisin, METRNL and various bone markers emphasises the strong interaction between these organs. This suggests that a dysregulation in the functional interaction between these molecules could play a possible role in the development of bone and muscle related complications that are associated with obesity and T2D.
Numerical Investigation of the Full-Scale Resistance of a Zero-Emission Fast Catamaran in Shallow Water
Authors: Shi Guangyu , Priftis Alexandros , Xing-Kaeding Yan , Boulougouris Evangelos , Papanikolaou Apostolos , Wang Haibin , Symonds Geoff
Published: April 2021

The present paper investigates numerically the resistance at full-scale of a zero-emission, high-speed catamaran in both deep and shallow water, with the Froude number ranging from 0.2 to 0.8. The numerical methods are validated by two means: a) comparison with available model tests; b) a blind validation using two different flow solvers. The resistance, sinkage and trim of the catamaran, as well as the wave pattern, longitudinal wave cuts and cross-flow fields, are examined. The total resistance curve in deep water shows a continuous increase with the Froude number while in shallow water, a hump is witnessed near the critical speed. This difference is mainly caused by the pressure component of total resistance, which is significantly affected by the interaction between the wave systems created by the demihulls. The pressure resistance in deep water is maximised at a Froude number around 0.58, whereas the peak in shallow water is achieved near the critical speed (Froude number ≈ 0.3). Insight into the underlying physics is obtained by analysing the wave creation between the demihulls. Profoundly different wave patterns within the inner region are observed in deep and shallow water. Specifically, in deep water, both crests and troughs are generated and moved astern as the increase of the Froude number. The maximum pressure resistance is accomplished when the secondary trough is created at the stern, leading to the largest trim angle. In contrast, the catamaran generates a critical wave normal to the advance direction in shallow water, which significantly elevates the bow and creates the highest trim angle as well as pressure resistance. Moreover, significant wave elevations are observed between the demihulls at supercritical speeds in shallow water which may affect the decision for the location of the wet deck.
HEXAMUF Interior Design Sebagai Solusi Keterbatasan Ruang Pada Kapal General Cargo
Authors: Utomo Agung Prasetyo , Utami Septaviola Dini , Setyawan Rizki Aris , Setiawan Ahmad Andrei
Published: April 2021

Desain Interior adalah proses merancang dan merencanakan suatu ruangan dengan mengedepankan aspek keindahan, kenyamanan, dan fungsi dari ruangan tersebut. Dengan seiring berkembangnya waktu sebuah ruangan dituntut dapat memberikan fungsi lebih dengan didukung furniture yang memadai walaupun dengan kapasitas ruangan yang terbatas layaknya ruangan pada sebuah kapal. Pada penelitian ini akan merancang sebuah furnitur dengan fungsi primer dan beberapa fungsi sekunder sehingga dapat mengurangi penggunaan furnitur yang lebih banyak pada ruang akomodasi kapal general cargo. Penelitian ini menerapkan perhitungan antropometri sehingga menghasilkan dimensi furniture yang ergonomis dan ramah terhadap bentuk tubuh manusia. Selain itu rancangan yang dibuat tidak meninggalkan segi keindahan dengan mengambil konsep minimalis modern. Rancangan ini mengambil sebuah bentuk alam dari sarang lebah yang dianggap memilki keunggulan dalam segi strukutur dan mudah dipadupadankan satu sama lain. Penelitian ini menghasilkan sebuah desain sofa sebagai fungsi primer dan tempat tidur, meja dan kursi sebagai fungsi sekunder dengan pemilihan material yang dianjurkan dalam sebuah kapal. Sofa ini dapat dibongkar pasang sesuai kebutuhan sehingga didapatkan fungsi sekundernya yang sangat cocok digunakan pada ruang yang tidak terlalu luas layaknya ruangan pada ruang akomodasi kapal.Kata Kunci: Design, Ergonomi, Estetika, Hexamuf, Multifungsi.
Pengaruh Perbandingan Resin Dan Katalis Terhadap Kekuatan Tarik Komposit Fiberglass-Polyester Untuk Bahan Pembuatan Kapal
Authors: Alamsyah Alamsyah , Hidayat Taufik , Iskandar Arif Nur
Published: April 2021

Penggunaan komposit berbahan dasar fiberglass banyak dijumpai dalam pembuatan kapal. Akan tetapi, penggunaan komposit pada proses pembuatan kapal belum memiliki standar mutu yang jelas dan baku mengenai perbandingan antara jumlah resin dan katalis yang digunakan. Sedangkan, jumlah penggunaan resin dan katalis memiliki pengaruh terhadap kekuatan dari komposit berpenguat serat. Penelitian ini bertujuan untuk mengetahui pengaruh jumlah katalis yang dicampurkan ke resin terhadap kekuatan tarik komposit fiberglass-polyester. Metode yang digunakan dalam penelitian ini adalah metode eksperimen yang menggunakan mesin pengujian tarik dengan memvariasikan jumlah katalis pada resin dari 0,5% sampai dengan 2%. Pada penelitian ini diperoleh hasil bahwa komposit dengan jumlah katalis 0,5% memiliki nilai kekuatan tarik 4,85 kgf/mm2, elongasi 2,43% dan modulus elastisitas 2,26 kgf/mm2. Komposit dengan jumlah katalis 1% memiliki nilai kekuatan tarik 5,02 kgf/mm2, elongasi 1,71% dan modulus elastisitas 2,96 kgf/mm2. Komposit dengan jumlah katalis 1,5% memiliki nilai kekuatan tarik 5,49 kgf/mm2, elongasi 1,97% dan modulus elastisitas 3,07 kgf/mm2. Komposit dengan jumlah katalis 2% memiliki nilai kekuatan tarik 4,97 kgf/mm2, elongasi 1,62% dan modulus elastisitas 3,11 kgf/mm2. Kekuatan tarik komposit fiberglass-polyester mengalami peningkatan di jumlah katalis 0,5 hingga 1,5% dan mengalami penurunan di jumlah katalis 2%.  Nilai kekuatan tarik tertinggi terdapat pada komposit dengan komposisi jumlah resin 100% dan jumlah katalis 1,5%.-
Analisis Kapasitas Teknis Struktur Dermaga Pelabuhan Lampia
Authors: Paotonan Chairul , Rahman Sabaruddin , Mas’ud M Ahmad Azwar , Putra Teguh Pairunan
Published: April 2021

PT. Sinergi Perkebunan Nusantara berencana menggunakan pelabuhan Lampia untuk pengapalan Crude Palm Oil (CPO). Dermaga Lampia telah berumur lebih dari sepuluh tahun sehingga daya dukungnya terhadap beban eksternal mungkin telah mengalami menurun.Oleh sebab itu untuk keamanan operasional kapal maka perlu dilakukan kajian terkait kapasitas teknis dermaga tersebut. Dengan diketahuinya kapasitas teknis dermaga maka dimensi kapal maksimum yang dapat dilayani dapat diketahui. Penelitian ini dimulai dari pengumpulan data pendukung yang terdiri dari data kapal, data hidro-oseanografi, data batimetri, data struktur dermaga dan data gempa. Selanjutnya dilakukan perhitungan beban yang bekerja pada dermaga yang terdiri dari beban mati dan beban hidup, beban gempa, beban benturan kapal, beban arus, beban gelombang, beban tarik kapal dan beban angin. Setelah perhitungan beban selesai, selanjutnya dilakukan pemodelan dermaga menggunakan perangkat lunak SAP2000 yang dilanjutkan dengan penginputan beban yang menggunakan kombinasi pembebanan tertentu serta dilakukan running model. Pada penelitian ini dilakukan variasi dimensi kapal yaitu 500 DWT, 700 DWT, 1000 DWT, 2000 DWT dan 3000 DWT. Indikator yang digunakan dalam menilai kapasitas teknis dermaga adalah safety factor (SF) sebagai fungsi dari DWT kapal. Berdasarkan hasil analisis kekuatan struktur dermaga, diperoleh bahwa dermaga eksisting mampu dan aman melayani kapal dengan ukuran ≤ 1027 DWT jika menggunakan safety factor (SF) 1,5. Sedangkan jika menggunakan safety factor (SF) 2,0 maka struktur dermaga eksisting mampu dan aman melayani kapal dengan ukuran ≤ 510 DWT.
Influence of Upwelling in the Southern Waters of Java on CO2 Concentration in Kototabang, Agam District West
Authors: Martono Martono , Putri Fanny Aditya
Published: April 2021

Absorption of atmospheric CO2 by the sea through two processes, namely solubility pumps and biological pumps. This study aims to determine the effect of upwelling in the southern waters of Java on atmospheric CO2 concentrations in Kototabang. The data used are in situ CO2 concentration, sea surface temperature and chlorophyll-a concentration from 2004-2016. The method used was descriptive analysis. The results showed that upwelling that occurred during JJA-SON caused a decrease in sea surface temperature to 26.8 °C and 27.1 °C respectively, as well as an increase chlorophyll-a concentration to 2.03 mg/m3 and 2.19 mg/m3. In both seasons CO2 concentration in Kototabang dropped to 385.8 ppm and 385.4 ppm. Meanwhile, when there was no upwelling during DJF-MAM, sea surface temperatures rose to 28.8 °C and 29.0 °C, and chlorophyll-a concentration dropped to 0.32 mg/m3 and 0.54 mg/m3. CO2 concentration in DJF and MAM increased to 386.3 ppm and 386.5 ppm. Based on these results it is known that when upwelling occurs, CO2 concentration decrease and vice versa.
EFIKASI DIRI MAHASISWA PESERTA KEGIATAN PERTUKARAN PELAJAR MELALUI PERKULIAHAN JARAK JAUH
Authors: Fatima Yashinta Meyliana , Nafisah Ainun , Lusiana Theresia Vivi , Dewi Sinta Sukma , Marmoah Sri
Published: April 2021

Kementerian Pendidikan dan Kebudayaan meluncurkan program Merdeka Belajar Kampus Merdeka yang salah satu kegiatannya adalah pertukaran pelajar. Namun adanya pandemik Covid-19 menyebabkan perkuliahan pada kegiatan pertukaran pelajar dilaksanakan secara jarak jauh (daring). Pembelajaran jarak jauh sering  menimbulkan masalah bagi mahasiswa seperti academic burnout, stres, dan kelelahan emosional. Penelitian ini bertujuan untuk mengetahui tingkat efikasi diri mahasiswa pada kegiatan pertukaran pelajar dalam pembelajaran daring. Metode yang digunakan dalam penelitian ini adalah survei. Teknik pengumpulan data dengan menyebar kuesioner pada 20 mahasiswa dan wawancara pada 6 mahasiswa peserta kegiatan pertukaran pelajar di program studi PGSD UNS-UNY. Lima faktor untuk melihat efikasi diri dalam menyelesaikan pembelajaran daring; berinteraksi secara sosial dengan teman sekelas; menangani alat di CMS (Course Management System); berinteraksi dengan instruktur di pembelajaran daring; dan berinteraksi dengan teman sekelas untuk tujuan akademis (Shen et al., 2013). Hasil penelitian menunjukkan tingkat efikasi diri mahasiswa pertukaran pelajar pada masa pembelajaran jarak jauh dalam kategori tinggi dan cukup tinggi. Mahasiswa memiliki keyakinan atau kepercayaan diri yang baik untuk mengikuti program transfer kredit dan berada pada kriteria tinggi.

 

The Ministry of Education and Culture launched merdeka belajar kampus merdeka program which one of the activities is student exchange. However, during the COVID-19 pandemic, the lecture activities in the meant programs is carried out remotely (online). Distance learning often poses problems for students such as academic burnout, stress, emotional fatigue. This study aims to determine the level of self-efficacy of the students who took part in the exchange program which conducted online. The method used in this research is mixed between survey and interview. Questionnaire was given to twenty students of PGSD UNS-UNY who join the exchange program through google form and six of them were interviewed. The results showed that the level of self-efficacy of UNS-UNY exchange student during distance learning is in moderate and high categories. It means that students have good self-confidence and in high criteria to join the credit transfer program. Researchers recommend further research to deepen information.
Unified Pressure and Rate Transient Analysis of Production and Shut-in Data from Fractured Horizontal Wells
Authors: Wang HanYi , Sharma Mukul , McGowen Harold
Published: April 2021

Market-induced production shut-downs and restarts offer us an opportunity to gather step-rate and shut-in data for pressure transient analysis (PTA) and rate transient analysis (RTA). In this study, we present a unified transient analysis (UTA) to combine PTA and RTA in a single framework. In this new approach continuous production data, step-rate data, shut-in data and re-start data can be visualized and analyzed in a single superposition plot, which can be used to estimate both Afk and infer formation pore pressure in a holistic manner by utilizing all available data. Most importantly, we show that traditional log-log and square root of time plots can lead to false interpretation of the termination of linear-flow or power-law behavior. Field cases are presented to demonstrate the superiority of the newly introduced superposition plot, along with discussion on the calibration of long-term bottom-hole pressure with short-term measurements.