bluuebunny/crossref_metadata_2025 huggingface dataset:
ABCC Transporter Gene MoABC-R1 Is Associated with Pyraclostrobin Tolerance in Magnaporthe oryzae
Authors: Hu Pei , Liu Yanchen , Zhu Xiaoli , Kang Houxiang
Published: September 2023

Rice blast is a worldwide fungal disease that poses a threat to food security. Fungicide treatment is one of the most effective methods to control rice blast disease. However, the emergence of fungicide tolerance hampers the control efforts against rice blast. ATP-binding cassette (ABC) transporters have been found to be crucial in multidrug tolerance in various phytopathogenic fungi. This study investigated the association between polymorphisms in 50 ABC transporters and pyraclostrobin sensitivity in 90 strains of rice blast fungus. As a result, we identified MoABC-R1, a gene associated with fungicide tolerance. MoABC-R1 belongs to the ABCC-type transporter families. Deletion mutants of MoABC-R1, abc-r1, exhibited high sensitivity to pyraclostrobin at the concentration of 0.01 μg/mL. Furthermore, the pathogenicity of abc-r1 was significantly diminished. These findings indicate that MoABC-R1 not only plays a pivotal role in fungicide tolerance but also regulates the pathogenicity of rice blast. Interestingly, the combination of MoABC-R1 deletion with fungicide treatment resulted in a three-fold increase in control efficiency against rice blast. This discovery highlights MoABC-R1 as a potential target gene for the management of rice blast.
Comparison of Fungal and Non-Fungal Rhinosinusitis by Culture-Based Analysis
Authors: Cha Chih-Hung , Chen Wei-Chih , Wang Yu-Ming , Wu Shao-Chun , Chiu Tai-Jan , Wu Ching-Nung , Wee Yinshen , Wang Ching-Shuen , Yang Yao-Hsu , Luo Sheng-Dean
Published: September 2023

Background: Incidence of fungal rhinosinusitis has increased in recent few years. We investigated the differences in microbiological findings between patients with fungal and non-fungal rhinosinusitis by growing microbiological cultures from samples obtained from sinus surgery. Methods: Using the Chang Gung Research Database, we enrolled all chronic rhinosinusitis (CRS) patients who had ever undergone sinus surgery from 2001 to 2019 and had microbiological culture during sinus surgery. Enrolled patients were divided into fungal and non-fungal groups, based on fungal culture and surgical pathology. Results: A total of 898 patients were diagnosed with fungal rhinosinusitis and 2884 with non-fungal rhinosinusitis. The fungal group had a higher age distribution (56.9 ± 13.1 vs. 47.0 ± 14.9), a larger proportion of females (62.4% vs. 37.0%), more unilateral lesions (80.4% vs. 41.6%), a lower incidence of the need for revision surgery (3.6% vs. 6.0%, p = 0.004), and a higher proportion of Pseudomonas aeruginosa in the culture (14.3% vs. 4.6%, p < 0.001). Conclusions: This large-scale study showed that Pseudomonas aeruginosa are more commonly found in patients with fungal rhinosinusitis and in patients who needed revision surgery, suggesting that efforts aimed at eliminating Pseudomonas are needed in order to improve the disease outcomes of patients with fungal rhinosinusitis.
Credit Risk Determinants in Selected Ethiopian Commercial Banks: A Panel Data Analysis
Authors: Muhammed Seid , Desalegn Goshu , Fekete-Farkas Maria , Bruder Emese
Published: September 2023

The study aims to investigate the factors that contribute to credit risk in Ethiopian commercial banks, considering both macroeconomic and bank-specific factors. The research utilized multiple regression models, a quantitative research approach, and explanatory research designs. A purposive sample technique was used to select 10 commercial banks for the study, and secondary data from audited financial reports were analyzed. The findings of the study reveal a significant positive relationship between credit risk and several variables, including bank size, profitability, efficiency, capital adequacy, and inflation. Conversely, there is an inverse relationship between credit risk and both loan growth and currency rates. Surprisingly, the study found that neither GDP nor interest rates have a significant impact on credit risk. Based on these findings, the study provides recommendations for Ethiopian commercial banks. It suggests maintaining adequate levels of capital, avoiding business in sectors influenced by inflationary pressures, carefully evaluating non-interest income, and adjusting lending policies as necessary. Furthermore, the study advises periodically examining the relationships between GDP growth, interest rates, and credit risk. It also emphasizes the importance of adapting credit risk management practices to changing market conditions and staying vigilant toward emerging trends.
Determining Attribute—Response Relationships of Soils under Different Land Uses: A Case Study
Authors: Secu Cristian Vasilică , Lesenciuc Dan Cristian , Vasiliniuc Ionuț , Zaldea Gabi , Nechita Ancuța , Alexandru Lulu Cătălin
Published: September 2023

Soil researchers are interested in a gaining better understanding of the soil system state by analyzing its properties and their dynamics in time as well as in relation to land use change. Tilled, abandoned, and forest soils were assessed regarding attribute–response relationships for the bulk density (BD), total porosity (TP), volumetric moisture (θv), and penetration resistance (PR) with the use of the interquartile ratio (IRI) integrated into a resilience formula and Shannon entropy indices. The IRI results differentiated soil properties according to agrotechnics (wheel track vs. between wheels) and the state of the system (tilled vs. abandoned vineyard). Entropy (En) indicated a high level of uncertainty for PR. The linear regression applied to the pairs of BD-TP, TP-θv, and PR-θv showed better results for the IRI weight (IRIweight) compared to the entropy weight (Enweight) for the soil between the wheels. The soil of the abandoned vineyard showed a faster tendency toward resilience that was more pronounced in the tilled wheel tracks than in the area between the wheels. The IRI can thus be an alternative to entropy in the evaluation of the response of some soil properties according to their use. When integrated into a resilience formula, the IRI can estimate the dynamics of soil properties for abandoned land compared to reference soil.
Changing Land Use and Urban Dynamics around an Industrial Zone in Bangladesh: A Remote Sensing Analysis
Authors: Basak Palash , Momtaz Salim , Gaston Troy F. , Dey Soma
Published: September 2023

This article examines the adverse effect of rapid industrialization around Bangladesh’s Dhaka Export Processing Zone (DEPZ) by analyzing Landsat satellite images captured between 1989 and 2019. Image classification was performed to separate built-up areas with machine learning algorithms in Google Earth Engine. Image analysis was conducted using ArcMap and ArcGIS Pro. Field observations, interviews, and the literature review provided information for explanations about the phenomenon observed from satellite image analyses. The findings reveal that when DEPZ started its operation in 1993, there was hardly any built-up area in the vicinity. Within three decades, over 25% of the land within a 5 km radius of DEPZ has been converted into a built-up area, triggering an almost seven-fold increase in population. Industrial and urban growth in the DEPZ area has caused significant soil and water pollution in the broader region. As a result, the quantity and quality of agricultural land has degraded. In the long run, the planned industrial development initiative has contributed to unsustainable urban growth and environmental consequences. Insights drawn from this article can guide policymakers to re-evaluate their policy for rapid and large-scale industrialization.
Urban Development and Transportation: Investigating Spatial Performance Indicators of 12 European Union Coastal Regions
Authors: Nikolaou Paraskevas , Basbas Socrates
Published: September 2023

Urbanization is one of the most dominant economic and social changes of the 20th century. This phenomenon brings about rapid urban development, which is inextricably linked to transport development. In order to understand this relationship, it is important to analyze the spatial spillover effects of the phenomenon in the urban environment. This study analyzes the spatial performance, in terms of urban development, of 12 European Union regions from five European countries with coastal areas by incorporating spatial data such as length of road network, population distribution, land uses, and other factors. Key performance indicators have been developed for evaluating the structural development model of the regions (e.g., dense or sprawl development). In addition, the incorporation of spatial spillover effects in the evaluation of the regions was conducted by the extended spatial data envelopment analysis (SDEA) method. The results of SDEA identified the best and worst-performing regions in terms of urban growth. Finally, this study implements a target-setting approach where under-performing regions can best perform. Based on the target-setting approach, local authorities can set realistic targets for improving the structural model that the regions are following.
Study of Optimal Conditions to Grow Thai Ganoderma, Fruiting Test, Proximate and Their Alpha Glucosidase Inhibitory Activity
Authors: Wannasawang Naruemon , Luangharn Thatsanee , Thawthong Anan , Charoensup Rawiwan , Jaidee Wuttichai , Tongdeesoontorn Wirongrong , Hyde Kevin D. , Thongklang Naritsada
Published: September 2023

Ganoderma (Ganodermataceae) has a worldwide distribution and has been widely used in traditional medicines. In this study, we report wild strains of Ganoderma that include two G. sichuanense and one G. orbiforme from northern Thailand. Optimal conditions for mycelium growth were ensured. The most favourable medium was potato sucrose agar for G. sichuanense and oatmeal agar for G. orbiforme and at 25 °C and 30 °C and pH 4–8. All types of cereal grains can be used to promote the growth of the mycelia of Ganoderma species. Fruiting tests were performed. All strains of Ganoderma produce fruiting bodies successfully in bag culture at 28 ± 1 °C with 75–85% relative humidity. Only G. orbiforme produced fruiting bodies in field cultivation at the laboratory scale. In the first flush yields, the G. sichuanense strain MFLUCC 22-0064 gave better production (the B.E was 152.35 ± 6.98 g). This study is the first to document the bag and field cultivation of wild Thai G. orbiforme. Ganoderma species are revealed to contain high amounts of fiber (47.90–52.45% d.b.), protein (12.80–14.67% d.b.), fat (4.90–5.70% d.b.), and carbohydrates (3.16–4.02% d.b.). Additionally, G. sichuanense and G. orbiforme were preliminarily screened for biological activity for inhibition of alpha–glucosidase enzyme activity. The IC50 values of G. orbiforme (MFLUCC 22-0066) was 105.97 ± 1.36 µg/mL and G. sichuanense (MFLUCC 22-0064) was 126.94 ± 0.87 µg/mL. Both strains had better inhibition than acarbose (168.18 ± 0.89 µM). These results on wild strains of Ganoderma will be useful for further studies on the applications of Ganoderma. Later the species can be introduced to domestic markets for cultivation and medicinal use.
First Report of a Low-Frequency Mosaic Mutation in the Hydroxymethylbilane Synthase Gene Causing Acute Intermittent Porphyria
Authors: Belosevic Adrian , Minder Anna-Elisabeth , Gueuning Morgan , van Breemen Franziska , Thun Gian Andri , Mattle-Greminger Maja P. , Meyer Stefan , Baumer Alessandra , Minder Elisabeth I. , Schneider-Yin Xiaoye , Barman-Aksözen Jasmin
Published: September 2023

Acute porphyrias are a group of monogenetic inborn errors of heme biosynthesis, characterized by acute and potentially life-threatening neurovisceral attacks upon exposure to certain triggering factors. Biochemical analyses can determine the type of acute porphyria, and subsequent genetic analysis allows for the identification of pathogenic variants in the specific gene, which provides information for family counselling. In 2017, a male Swiss patient was diagnosed with an acute porphyria while suffering from an acute attack. The pattern of porphyrin metabolite excretion in urine, faeces, and plasma was typical for an acute intermittent porphyria (AIP), which is caused by inherited autosomal dominant mutations in the gene for hydroxymethylbilane synthase (HMBS), the third enzyme in the heme biosynthetic pathway. However, the measurement of HMBS enzymatic activity in the erythrocytes was within the normal range and Sanger sequencing of the HMBS gene failed to detect any pathogenic variants. To explore the molecular basis of the apparent AIP in this patient, we performed third-generation long-read single-molecule sequencing (nanopore sequencing) on a PCR product spanning the entire HMBS gene, including the intronic sequences. We identified a known pathogenic variant, c.77G>A, p.(Arg26His), in exon 3 at an allelic frequency of ~22% in the patient’s blood. The absence of the pathogenic variant in the DNA of the parents and the results of additional confirmatory studies supported the presence of a de novo mosaic mutation. To our knowledge, such a mutation has not been previously described in any acute porphyria. Therefore, de novo mosaic mutations should be considered as potential causes of acute porphyrias when no pathogenic genetic variant can be identified through routine molecular diagnostics.
Open Questions about the Roles of DnaA, Related Proteins, and Hyperstructure Dynamics in the Cell Cycle
Authors: Kohiyama Masamichi , Herrick John , Norris Vic
Published: September 2023

The DnaA protein has long been considered to play the key role in the initiation of chromosome replication in modern bacteria. Many questions about this role, however, remain unanswered. Here, we raise these questions within a framework based on the dynamics of hyperstructures, alias large assemblies of molecules and macromolecules that perform a function. In these dynamics, hyperstructures can (1) emit and receive signals or (2) fuse and separate from one another. We ask whether the DnaA-based initiation hyperstructure acts as a logic gate receiving information from the membrane, the chromosome, and metabolism to trigger replication; we try to phrase some of these questions in terms of DNA supercoiling, strand opening, glycolytic enzymes, SeqA, ribonucleotide reductase, the macromolecular synthesis operon, post-translational modifications, and metabolic pools. Finally, we ask whether, underpinning the regulation of the cell cycle, there is a physico-chemical clock inherited from the first protocells, and whether this clock emits a single signal that triggers both chromosome replication and cell division.
Association of Atrial Fibrillation Recurrence with Right Coronary Atherosclerosis and Increased Left Arterial Epicardial Fat Following Catheter Ablation—Results of a Multimodality Study
Authors: Bordi Lehel László , Benedek Theodora , Kovács István , Opincariu Diana , Márton Emese , Parajkó Zsolt , Gerculy Renáta , Benedek Imre
Published: September 2023

Background: Identification of predictors for atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI) can lead to better long-term results. Our aim was to investigate the association between novel CT imaging markers reflecting the severity of coronary atherosclerosis and the risk of recurrence following PVI. Methods: This study included 80 patients with paroxysmal/persistent AF who underwent PVI. The patients were divided into two groups: Group 1–23 patients with recurrence and Group 2–57 patients without recurrence. Results: Patients with recurrence presented with a more enlarged left atrial diameter and reduced left ventricle EF, as assessed by echocardiography. Elevated calcium scores and right coronary artery (RCA) stenosis were correlated with a higher risk of AF recurrence (25.38 ± 4.1% vs. 9.76 ± 2.32%, p = 0.001). Patients with AF recurrence presented a higher left atrial volume index (LAVI) (61.38 ± 11.12 mm3/m2 vs. 46.34 ± 12.27 mm3/m2, p < 0.0001). The bi-atrial volume index (BAVI) was similarly higher in the AF recurrence group (98.23 ± 14.44 mm3/m2 vs. 76.48 ± 17.61 mm3/m2, p < 0.0001). Increased EAT volumes located around the LA (EAT-LA) were correlated with recurrence (25.55 ± 6.37 vs. 15.54 ± 8.44, p < 0.0001). Conclusions: RCA stenosis, together with atrial volumes and EAT-AS evaluated by CCTA, is associated with the risk of AF recurrence following PVI.
Improving Structural MRI Preprocessing with Hybrid Transformer GANs
Authors: Grigas Ovidijus , Maskeliūnas Rytis , Damaševičius Robertas
Published: September 2023

Magnetic resonance imaging (MRI) is a technique that is widely used in practice to evaluate any pathologies in the human body. One of the areas of interest is the human brain. Naturally, MR images are low-resolution and contain noise due to signal interference, the patient’s body’s radio-frequency emissions and smaller Tesla coil counts in the machinery. There is a need to solve this problem, as MR tomographs that have the capability of capturing high-resolution images are extremely expensive and the length of the procedure to capture such images increases by the order of magnitude. Vision transformers have lately shown state-of-the-art results in super-resolution tasks; therefore, we decided to evaluate whether we can employ them for structural MRI super-resolution tasks. A literature review showed that similar methods do not focus on perceptual image quality because upscaled images are often blurry and are subjectively of poor quality. Knowing this, we propose a methodology called HR-MRI-GAN, which is a hybrid transformer generative adversarial network capable of increasing resolution and removing noise from 2D T1w MRI slice images. Experiments show that our method quantitatively outperforms other SOTA methods in terms of perceptual image quality and is capable of subjectively generalizing to unseen data. During the experiments, we additionally identified that the visual saliency-induced index metric is not applicable to MRI perceptual quality assessment and that general-purpose denoising networks are effective when removing noise from MR images.
Improved Uniformity of TaOx-Based Resistive Switching Memory Device by Inserting Thin SiO2 Layer for Neuromorphic System
Authors: Ju Dongyeol , Kim Sunghun , Jang Junwon , Kim Sungjun
Published: September 2023

RRAM devices operating based on the creation of conductive filaments via the migration of oxygen vacancies are widely studied as promising candidates for next-generation memory devices due to their superior memory characteristics. However, the issues of variation in the resistance state and operating voltage remain key issues that must be addressed. In this study, we propose a TaOx/SiO2 bilayer device, where the inserted SiO2 layer localizes the conductive path, improving uniformity during cycle-to-cycle endurance and retention. Transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) confirm the device structure and chemical properties. In addition, various electric pulses are used to investigate the neuromorphic system properties of the device, revealing its good potential for future memory device applications.
Effects of Heating Rates on Microstructural Evolution of Hot Extruded 7075 Aluminum Alloy in the Semi-Solid State and Thixotropic Deformation Behavior
Authors: Gu Guochao , Li Ruifen , Xiang Lixin , Xiao Guiyong , Lu Yupeng
Published: September 2023

The non-dendritic microstructure plays a crucial role in determining the rheological properties of semi-solid alloys, which are of the utmost importance for the successful industrial application of the thixoforging process. To further understand the impact of the reheating process on the evolution of microstructure and thixotropic deformation behavior in the semi-solid state, a hot extruded and T6 treated 7075 aluminum alloy was reheated to the selected temperature ranges using varying heating rates. Subsequently, thixo-compression tests were performed. The study found that during reheating and isothermal holding, the elongated microstructure of the as-supplied alloy can transform into equiaxed or spherical grains. The presence of recrystallized grains was found to be closely linked to the penetration of the liquid phase into the recrystallized grain boundaries. Furthermore, it was observed that higher heating rates resulted in smaller grain sizes. The thixotropic flow behavior of the alloy with various microstructures was analyzed using the true stress–strain curves obtained by thixo-compression experiments, which exhibited three stages: a rapid increase in true stress to a peak value, followed by a decrease in true stress and a steady stress until the end of compression. The stress fluctuated with strain during the formation of the slurry at a strain rate of 10 s−1, indicating the significant role of strain rate in material flow during semisolid formation.
Ergonomic Design of an Adaptive Automation Assembly System
Authors: Bortolini Marco , Botti Lucia , Galizia Francesco Gabriele , Mora Cristina
Published: September 2023

Ergonomics is a key factor in the improvement of health and productivity in workplaces. Its use in improving the performance of a manufacturing process and its positive effects on productivity and human performance is drawing the attention of researchers and practitioners in the field of industrial engineering. This paper proposes an ergonomic design approach applied to an innovative prototype of an adaptive automation assembly system (A3S) equipped with Microsoft Kinect™ for real-time adjustment. The system acquires the anthropometric measurements of the operator by means of the 3-D sensing device and changes its layout, arranging the mobile elements accordingly. The aim of this study was to adapt the assembly workstation to the operator dimensions, improving the ergonomics of the workstation and reducing the risks of negative effects on workers’ health and safety. The case study of an assembly operation of a centrifugal electric pump is described to validate the proposed approach. The assembly operation was simulated at a traditional fixed workstation and at the A3S. The shoulder flexion angle during the assembly tasks at the A3S reduced between 18% and 47%. The ergonomic risk assessment confirmed the improvement of the ergonomic conditions and the ergonomic benefits of the A3S.
Coupled Electromagnetic–Fluid–Thermal Analysis of a Fully Air-Cooled Pumped Storage Generator Motor
Authors: Zhang Shukuan , Wang Fachen , Wang Hongtao , Shao Zhe , Zhao Hongge , Zhu Jingwei
Published: September 2023

With the continuous increase in the capacity of the pumped storage generator motor, the overheating of the rotor area is becoming increasingly severe, which has a significant effect on the safe and reliable operation of the machine. The heat dissipation of the machine rotor by fully air-cooled is one of the key technologies to develop the new generation of pumped storage generator motors. In this paper, the electromagnetic field and fluid–thermal coupled field of a pumped storage generator motor are analyzed. The 2D transient time-step finite element model of the electromagnetic field of a pumped storage generator motor is established, and the eddy current loss of damping bars of the rotor is calculated by the finite element method. The additional loss of the rotor pole surface is calculated by analytical method. The mathematical and geometric models of the 3D fluid–thermal coupled field of the pumped storage generator motor are established and calculated. The complex fluid velocity distribution and the temperature distribution at different positions of the rotor under fully air-cooled fanless cooling conditions are investigated in detail. The calculated temperature of field winding is compared with the measured value, and the result shows that the calculated result coincident well with the test data. This research provides the technical reference for the development and temperature rise calculation for large pumped storage generator motors.
Memory Tensor for Non-Markovian Dynamics with Random Hamiltonian
Authors: Teretenkov Alexander Evgen’evich
Published: September 2023

In the theory of open quantum systems, the Markovian approximation is very widespread. Usually, it assumes the Gorini–Kossakowski–Sudarshan–Lindblad (GKSL) equation for density matrix dynamics and quantum regression formulae for multi-time correlation functions. Nevertheless, now, quantum non-Markovianity is being actively studied, especially the non-Markovianity of multi-time correlations. In this work, we consider dynamics with a random Hamiltonian, which can lead to GKSL dynamics of the density matrix for some special cases, but correlation functions generally do not satisfy the quantum regression formulae. Despite the fact that random Hamiltonians have been actively studied, dynamics with such Hamiltonians has been little discussed from the viewpoint of multi-time correlations. For specific models with a random Hamiltonian, we provide the formulae for multi-time correlations which occur instead of the usual regression formulae. Moreover, we introduce and calculate the memory tensor, which characterizes multi-time correlations against the Markovian ones. We think that, despite being applied to specific models, the methods developed in this work can be used in a much broader setup.
Improving Wild Horse Optimizer: Integrating Multistrategy for Robust Performance across Multiple Engineering Problems and Evaluation Benchmarks
Authors: Chen Lei , Zhao Yikai , Ma Yunpeng , Zhao Bingjie , Feng Changzhou
Published: September 2023

In recent years, optimization problems have received extensive attention from researchers, and metaheuristic algorithms have been proposed and applied to solve complex optimization problems. The wild horse optimizer (WHO) is a new metaheuristic algorithm based on the social behavior of wild horses. Compared with the popular metaheuristic algorithms, it has excellent performance in solving engineering problems. However, it still suffers from the problem of insufficient convergence accuracy and low exploration ability. This article presents an improved wild horse optimizer (I-WHO) with early warning and competition mechanisms to enhance the performance of the algorithm, which incorporates three strategies. First, the random operator is introduced to improve the adaptive parameters and the search accuracy of the algorithm. Second, an early warning strategy is proposed to improve the position update formula and increase the population diversity during grazing. Third, a competition selection mechanism is added, and the search agent position formula is updated to enhance the search accuracy of the multimodal search at the exploitation stage of the algorithm. In this article, 25 benchmark functions (Dim = 30, 60, 90, and 500) are tested, and the complexity of the I-WHO algorithm is analyzed. Meanwhile, it is compared with six popular metaheuristic algorithms, and it is verified by the Wilcoxon signed-rank test and four real-world engineering problems. The experimental results show that I-WHO has significantly improved search accuracy, showing preferable superiority and stability.
Detectability in Discrete Event Systems Using Unbounded Petri Nets
Authors: Zhu Haoming , Liu Gaiyun , Yu Zhenhua , Li Zhiwu
Published: September 2023

This paper investigated the verification of detectability for discrete event systems based on a class of partially observed unbounded Petri nets. In an unbounded net system, all transitions and partial places are assumed to be unobservable. The system administrator can only observe a few observable places, i.e., the number of tokens at these places can be observed, allowing for the estimation of current and subsequent states. The concepts of quasi-observable transitions, truly unobservable transitions, and partial markings are used to construct a basis coverability graph. According to this graph, four sufficient and necessary conditions of detectability are proposed. Correspondingly, a specific example is proposed to prove that the detectability can be verified in the unbounded net system. Furthermore, based on the conclusion of detectability, the system’s ability to detect critical states was explored by using the basis coverability graph, called C-detectability. Two real-world examples are proposed to show that the detectability of discrete event systems has not only pioneered new research methods, but also demonstrated that the real conditions faced by this method are more general, and it has overcome the limitations of relying only on the ideal conditions of bounded systems for verification.
Benford’s Law in Electric Distribution Network
Authors: Petráš Jaroslav , Pavlík Marek , Zbojovský Ján , Hyseni Ardian , Dudiak Jozef
Published: September 2023

Benford’s law can be used as a method to detect non-natural changes in data sets with certain properties; in our case, the dataset was collected from electricity metering devices. In this paper, we present a theoretical background behind this law. We applied Benford’s law first digit probability distribution test for electricity metering data sets acquired from smart electricity meters, i.e., the natural data of electricity consumption acquired during a specific time interval. We present the results of Benford’s law distribution for an original measured dataset with no artificial intervention and a set of results for different kinds of affected datasets created by simulated artificial intervention. Comparing these two dataset types with each other and with the theoretical probability distribution provided us the proof that with this kind of data, Benford’s law can be applied and that it can extract the dataset’s artificial manipulation markers. As presented in the results part of the article, non-affected datasets mostly have a deviation from BL theoretical probability values below 10%, rarely between 10% and 20%. On the other side, simulated affected datasets show deviations mostly above 20%, often approximately 70%, but rarely lower than 20%, and this only in the case of affecting a small part of the original dataset (10%), which represents only a small magnitude of intervention.
Efficient Conditional Privacy-Preserving Authentication Scheme for Safety Warning System in Edge-Assisted Internet of Things
Authors: Li Jianfeng , Hou Na , Zhang Guangwei , Zhang Jihao , Liu Yu , Gao Xiang
Published: September 2023

With the advent of smart cities, the significance of the Internet of Things (IoT) is gaining greater prominence. At the same time, the safety early warning system in the IoT has a significant impact on real-time monitoring and the response to potential risks. Despite the advancements made in edge-assisted IoT deployments, several challenges and constraints persist. Given the potential threat to life posed by safety-related messages, ensuring the authenticity of messages in the edge-assisted IoT safety warning system is crucial. However, considering the identity privacy of devices participating in the edge-assisted Internet of Things system, directly verifying the identity of the sending device is undesirable. To address this issue, in this work, we design a linkable group signature scheme that allows devices to anonymously send safety-related messages to edge nodes, defending against Sybil attacks while ensuring the traceability of malicious device identities. Then, we present a high-efficiency conditional privacy-preserving authentication (CPPA) scheme based on the designed group signatures for the safety warning system in edge-assisted IoT. This scheme effectively protects device identity privacy while providing a reliable authentication mechanism to ensure the credibility and traceability of alert messages. The proposed scheme contributes to the field of safety warning systems in the context of edge-assisted IoT, providing a robust solution for privacy preservation and authentication.
Bartter Syndrome: A Systematic Review of Case Reports and Case Series
Authors: Qasba Rakhtan K. , Bucharles Anna Carolina Flumignan , Piccoli Maria Victoria Ferreira , Sharma Pranjal , Banga Akshat , Kamaraj Balakrishnan , Nawaz Faisal A. , Kumar Harshadayani Jagadish , Happy Mahika Afrin , Qasba Ruman K. , Kogilathota Jagirdhar Gowthami Sai , Essar Mohammad Yasir , Garg Piyush , Reddy Shiva Teja , Rama Kaanthi , Surani Salim , Kashyap Rahul
Published: September 2023

Background and Objectives: Bartter syndrome (BS) is a rare group of autosomal-recessive disorders that usually presents with hypokalemic metabolic alkalosis, occasionally with hyponatremia and hypochloremia. The clinical presentation of BS is heterogeneous, with a wide variety of genetic variants. The aim of this systematic review was to examine the available literature and provide an overview of the case reports and case series on BS. Materials and Methods: Case reports/series published from April 2012 to April 2022 were searched through Pubmed, JSTOR, Cochrane, ScienceDirect, and DOAJ. Subsequently, the information was extracted in order to characterize the clinical presentation, laboratory results, treatment options, and follow-up of the patients with BS. Results: Overall, 118 patients, 48 case reports, and 9 case series (n = 70) were identified. Out of these, the majority of patients were male (n = 68). A total of 21 patients were born from consanguineous marriages. Most cases were reported from Asia (73.72%) and Europe (15.25%). In total, 100 BS patients displayed the genetic variants, with most of these being reported as Type III (n = 59), followed by Type II (n = 19), Type I (n = 14), Type IV (n = 7), and only 1 as Type V. The most common symptoms included polyuria, polydipsia, vomiting, and dehydration. Some of the commonly used treatments were indomethacin, potassium chloride supplements, and spironolactone. The length of the follow-up time varied from 1 month to 14 years. Conclusions: Our systematic review was able to summarize the clinical characteristics, presentation, and treatment plans of BS patients. The findings from this review can be effectively applied in the diagnosis and patient management of individuals with BS, rendering it a valuable resource for nephrologists in their routine clinical practice.
Belbin’s Team Role Balance and Team Effectiveness in Community Mental Health Teams in an Area of Northwest Ireland: Implications for Leadership
Authors: Adamis Dimitrios , Krompa Georgia Maria , Rauf Abdul , Mulligan Owen , O’Mahony Edmond
Published: September 2023

Community Mental Health Teams (CMHTs) have been introduced as an alternative to hospital-based treatment. Their effectiveness and the factors that may influence it have not yet been fully investigated. According to Belbin’s theory, a team is more effective if its members have diverse roles. The aim of this study was to investigate if there is an association between CMHTs’ effectiveness and Belbin’s team role balance. Participants were members of eight CMHTs. The data collected were demographics (age, gender), discipline, years of experience, and team tenure. Also, the following scales were administered: the Belbin Team Role Self-Perception Inventory (SPI) and team effectiveness scale (TES). One hundred and six members participated. A significant correlation between team role diversity and effectiveness was found. Multilevel analysis showed that role diversity and being a doctor were the only two significant independent predictors of team effectiveness. Belbin’s theory is therefore applicable to CMHTs. The more diverse roles the members of a team have, the better the effectiveness of the team. Given that roles can be modified, team leaders need to be aware of the members’ roles and be able to modify them. Thus, they can increase the effectiveness of their teams.
Investigations into the Microstructure and Texture Evolution of Inertia-Friction-Welded Dissimilar Titanium Alloys
Authors: Zhou Jun , Wu Yanquan , Zhang Chunbo , Liang Wu , Li Rui , Qin Feng
Published: September 2023

The welded joint of a dissimilar titanium alloy was obtained via inertial friction welding technology. The characteristics of the bonding interface and the microstructure of the welded joint were investigated via optical microscopy, scanning electron microscopy and electron backscattered diffraction. The results show that fine, equiaxed grains and interdiffusion bands of the elements Mo and Sn were formed in the weld zone under the high temperature and plastic deformation of the inertial friction welding. The weld zone and thermo-mechanically affected zone formed ⟨1¯21¯0⟩ α texture and ⟨111⟩ β texture, respectively.
Study on the Targeted Improvement Mechanism of the Carrier Concentration and Mobility of BiCuSeO Ceramics
Authors: Wang Zhibin , Zhao Hong , Luo Xinyu , Han Wenyuan , Wang Hao , Meng Linghao , She Xinqi , Quan Anlong , Peng Yixin , Cai Guoji , Liu Yi , Tang Yong , Feng Bo
Published: September 2023

BiCuSeO has great application prospects in thermoelectric power generation and thermoelectric catalysis, but it is limited by its lower thermoelectric performance. Herein, BiCuSeO bulk materials were prepared using a solid-phase reaction method and a ball-milling method combined with spark plasma sintering, and then the thermoelectric properties were improved by synergistically increasing carrier concentration and mobility. Al was adopted to dope into the BiCuSeO matrix, aiming to adjust the carrier mobility through energy band adjustment. The results show that Al doping would widen the bandgap and enhance the carrier mobility of BiCuSeO. After Al doping, the thermoelectric properties of the material are improved in the middle- and high-temperature range. Based on Al doping, Pb is adopted as the doping element to dope BiCuSeO to modify the carrier concentration. The results show that Al/Pb dual doping in the BiCuSeO matrix can increase the carrier concentration under the premise of increasing carrier mobility. Therefore, the electrical conductivity of BiCuSeO can be improved while maintaining a large Seebeck coefficient. The power factor of Al/Pb doping reached ~7.67 μWcm−1K−2 at 873 K. At the same time, the thermal conductivity of all doped samples within the test temperature range maintained a low level (<1.2 Wm−1K−1). Finally, the ZT value of the Al/Pb-doped BiCuSeO reached ~1.14 at 873 K, which is ~2.72 times that of the pure phase, and the thermoelectric properties of the matrix were effectively improved.
Unveiling the Potency and Harnessing the Antibacterial Activities of Plant Oils against Foodborne Pathogens
Authors: Selvarajan Vijaya Samoondeeswari , Selvarajan Ramganesh , Pandiyan Jeevan , Abia Akebe Luther King
Published: September 2023

The rising concerns regarding antibiotic resistance and the harmful effects of synthetic preservatives have led to an increasing interest in exploring natural alternatives. Plant oils have been traditionally used for their antimicrobial properties, but systematic investigations into their efficacy against foodborne pathogens are necessary for potential applications in food preservation. This study aimed to evaluate the antibacterial potential of various plant oils (neem, coconut, castor, and olive oil) against common foodborne pathogens and analyze their chemical composition using gas chromatography–mass spectrometry (GC-MS). The oils were tested against foodborne pathogens using the disk diffusion method. Minimum inhibitory concentrations (MICs) were determined to assess the potency of the oils. GC-MS was employed to identify the compounds present in each oil. Neem oil exhibited significant antibacterial activity against all tested pathogens, with pronounced effects against Staphylococcus aureus and Bacillus cereus. Coconut oil showed notable activity against Listeria monocytogenes. Castor oil displayed moderate activity, while olive oil exhibited minimal antibacterial effects. The GC-MS analysis revealed a diverse array of compounds in neem oil, which is likely to contribute to its potent antibacterial properties. Neem and coconut oils, owing to their rich bioactive components, emerged as promising candidates for the development of natural antimicrobial agents. These brief findings support the potential application of plant oils in food preservation and emphasize the need for further research into understanding the underlying mechanisms and optimizing their use.
Kinetic Study on the Base-Catalyzed Imine-Enamine Tautomerism of a Chiral Biologically Active Isoxazoline Derivative by HPLC on Amylose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase
Authors: Sadutto Daniele , Guglielmi Paolo , Carradori Simone , Secci Daniela , Cirilli Roberto
Published: September 2023

Isoxazoline is a nitrogen- and oxygen-containing five-membered heterocyclic scaffold with diverse biological profiles such as antimicrobial, fungicidal, anticancer, antiviral, analgesic and anti-inflammatory activity. Accordingly, the use of this peculiar structural framework in drug discovery is a successful strategy for the development of new drug candidates. Here, a chiral saccharin/isoxazoline hybrid was considered to investigate the tendency of the imine moiety of the heterocyclic ring to tautomerize to the enamine form in the presence of a basic catalyst. The pseudo-first-order rate constants for the base-catalyzed tautomerization process were measured in different solvents and at different temperatures by off-column kinetic experiments based on the amylose (3,5-dimethylphenylcarbamate)-type chiral stationary phase. The kinetic results obtained in this study may be a useful aid in the perspective of designing experimental conditions to control the stereointegrity of these types of pharmacologically active compounds and drive their synthesis toward the preferred, imine or enamine, tautomer.
Compositing Benzothieno[3,2-b]Benzofuran Derivatives with Single-Walled Carbon Nanotubes for Enhanced Thermoelectric Performance
Authors: Li Yiyang , Ai Liankun , Luo Qunyi , Wu Xin , Li Baolin , Guo Cun-Yue
Published: September 2023

Although numerous thermoelectric (TE) composites of organic materials and single-walled carbon nanotubes (SWCNTs) have been developed in the past decade, most of the research has been related to polymers without much on organic small molecules (OSMs). In this work, benzothieno[3,2-b]benzofuran (BTBF) and its derivatives (BTBF-Br and BTBF-2Br) were synthesized and their TE composites with SWCNTs were prepared. It is found that the highest molecular orbital level and band gap (Eg) of BTBF, BTBF-Br, and BTBF-2Br gradually decrease upon the introduction of electron-withdrawing Br group on BTBF. These changes significantly improve the Seebeck coefficient and power factor (PF) of OSM/SWCNT composites. An appropriate energy barrier between BTBF-2Br and SWCNTs promotes the energy filtering effect, which further contributes to the enhancement of composites’ thermoelectric properties. The composites of SWCNTs and BTBF-2Br with the smallest Eg (4.192 eV) afford the best thermoelectric performance with the room temperature power factor of 169.70 ± 3.46 μW m−1 K−2 in addition to good mechanical flexibility and thermal stability. This study provides a feasible strategy for the preparation of OSM/SWCNT composites with improved thermoelectric properties.
Comprehensive Analysis of the Chemical and Bioactivity Profiles of Endemic Crataegus turcicus Dönmez in Comparison with Other Crataegus Species
Authors: Turnalar Ülger Tansu , Oçkun Mehmet Ali , Guzelmeric Etil , Sen Nisa Beril , Sipahi Hande , Özhan Yağmur , Kan Yüksel , Yesilada Erdem
Published: September 2023

Crataegus turcicus is a plant endemic to Türkiye. For the first time, this study aimed to comparatively assess its flower-bearing branches, leaves, and fruits with other well-known Crataegus species (C. monogyna, C. pentagyna, and C. orientalis) in terms of chemical composition and bioactivity studies to evaluate its potential use as a food supplement. Firstly, the contents of total phenolics (TPC), flavonoids (TFC), proanthocyanidin (TPAC), and anthocyanin (TAC) in different plant parts of Crataegus species were evaluated. The highest TPAC was found in the hydroalcoholic extract of C. turcicus flower-bearing branches. Moreover, all plant parts had comparatively higher amounts of TPC, TFC, and TAC compared to other Crataegus species. The chemical screening by high-performance thin-layer chromatography (HPTLC) resulted that C. turcicus parts were rich with chlorogenic acid, neochlorogenic acid, quercetin and vitexin derivatives, epicatechin, procyanidin, etc., and their quantities were evaluated by high-performance liquid chromatography (HPLC). In terms of several in vitro antioxidant activity outcomes, the flower-bearing branches of C. turcicus showed the highest antioxidant activity by a 2,2-diphenyl-1-picrylhydrazyl (DPPH) test among the assessed antioxidant assays. Additionally, hydroalcoholic extracts of C. turcicus significantly decreased LPS-induced nitric oxide, tumor necrosis factor-alpha, and interleukin-6 production more potently than indomethacin (positive control). In addition to its remarkable anti-inflammatory activity, C. turcicus showed analgesic activity by reducing prostaglandin E2 levels.
Development of a Colorimetric Paper Sensor for Hg2+ Detection in Water Using Cyanuric Acid-Conjugated Gold Nanoparticles
Authors: Saputri Febrina Amelia , Zubaidah Eka Ulya , Kenanga Amaranggani Wikan Puspita , Jatmika Catur , Pratiwi Rimadani , Dhumale Vinayak A.
Published: September 2023

Hg2+ is one of the most dangerous pollutants that can cause damage to organs and the immune system. The common detection methods of Hg2+ require sophisticated instrumentation and a long time for analysis. The purpose of this study was to develop a sensor for the detection of Hg2+ using filter paper immobilized by gold nanoparticles (AuNPs) conjugated with cyanuric acid (CA). The clear color change from pink to bluish purple is the response of the CA-AuNPs filter paper sensor to exposure to Hg2+. Detection can be observed visually with the naked eye and/or with imageJ software; the detection limit is 0.05 µM. The colorimetric response of the sensor was also selective towards Hg2+ after testing with different metal ions. In addition, the response from the sensor was also consistent for lake water samples spiked with Hg2+. The results of this research provide a promising basic technology for the development of sensors that are affordable, fast, portable, and easy to use for the detection and monitoring of Hg2+ levels in water.
Flavones and Related Compounds: Synthesis and Biological Activity
Authors: Leonte Denisa , Ungureanu Daniel , Zaharia Valentin
Published: September 2023

This review focuses on the synthesis and biological activity of flavones and their related flavonoidic compounds, namely flavonols and aurones. Among the biological activities of natural and synthetic flavones and aurones, their anticancer, antioxidant, and antimicrobial properties are highlighted and detailed in this review. Starting from the structures of natural flavones acting on multiple anticancer targets (myricetin, genkwanin, and other structurally related compounds), new flavone analogs were recently designed and evaluated for their anticancer activity. The most representative compounds and their anticancer activity are summarized in this review. Natural flavones recognized for their antimicrobial properties (baicalein, luteolin, quercetol, apigenin, kaempferol, tricin) have been recently derivatized or structurally modulated by chemical synthetic methods in order to obtain new effective antimicrobial flavonoidic derivatives with improved biological properties. The most promising antimicrobial agents are systematically highlighted in this review. The most applied method for the synthesis of flavones and aurones is based on the oxidative cyclization of o-hydroxychalcones. Depending on the reaction conditions and the structure of the precursor, in some cases, several cyclization products result simultaneously: flavones, flavanones, flavonols, and aurones. Based on the literature data and the results obtained by our research group, our aim is to highlight the most promising methods for the synthesis of flavones, as well as the synthetic routes for the other structurally related cyclization products, such as hydroxyflavones and aurones, while considering that, in practice, it is difficult to predict which is the main or exclusive cyclization product of o-hydroxychalcones under certain reaction conditions.