bluuebunny/crossref_metadata_2025 huggingface dataset:
Cuentos felinos 7
Authors: Ramírez C Clinton , Acosta Acosta Martiniano , Ariza Navarro Adolfo , Cabarcas Salas David , Cabrera González Jaime , Celis Roberto , Florez Brum Andrés Elías , Garcés González José Luis , Gracián Petro Naudín , Manjarrés Freyle Annabell , Morales Aguilar Álvaro , Tedio Guillermo
Published: August 2023

Cuentos felinos es una de la aventuras de la imaginación más fecundas de la historia reciente de la literatura del norte de Colombia. Confirma el carácter de los creadores de una región inquieta, fecunda, irreverente, con la virtud de calzar sus propios zapatos y asistir a sus propias fiestas. Los autores congregados en esta nueva entrega, además de ser grandes narradores, figuran entre los más consumados exponentes del cuento en su país: género que para ellos no pareciera tener fronteras imposibles. Los lectores colombianos son privilegiados, aunque todavía lo ignoren y solo lo confirmen cuando en unos años recorran admirados y con fruición las espléndidas páginas de Cuentos felinos 7, un libro en la mejor línea de la literatura desinteresada, a la larga la llamada a prevalecer, a hacer historia.
An Updated Review For Hyperuricemia and Gout Management; Special Focus on the Available Drug Delivery Systems and Clinical Trials
Authors: Karantas Ioannis D. , Miliotou Androulla N. , Siafaka Panoraia I.
Published: August 2023

Background:

Hyperuricemia belongs to metabolic syndromes where increased uric
acid levels are identified in the blood serum. Such a syndrome could be responsible for kidney
stone formation, gout, hypertension, and chronic kidney diseases. It has been reported
that cardiovascular risks have been linked with hyperuricemia. Gout is of the most frequent
manifestations due to hyperuricemia; its management involves various pharmacological available
options and dietary changes. Throughout the literature, various dosage forms are studied
as alternative options to the present drug delivery systems.

Objective:

To update and summarize the current information for gout and hyperuricemia management.

Methods:

Authors have performed a thorough literature research from 2010-2023 using keywords
such as hyperuricemia, gout, diagnosis, guidelines, drug delivery and clinical trials.
The databases used were PubMed, ScienceDirect. According to our inclusion criteria, all
studies which include the previous terms, as well as drugs or other molecules that can be applied
for gout and/or hyperuricemia management, were added.

Results:

In this article, authors have summarized the pathogenesis, diagnosis and updated
guidelines for gout and hyperuricemia management. Moreover, the authors have reviewed
and discussed current drug delivery systems found in the literature, including drugs targeting
the above disorders. Finally, the available clinical trials assessing the efficacy of newer drugs
or combinations of the past ones, are being discussed.

Conclusion:

The available drugs and dosage forms are limited, and therefore, scientific society
should focus on the development of more efficient drug delivery systems for hyperuricemia
and gout management.
Development and Validation of a Simple, Fast, and Accessible HPLC-UV
Method for Cannabinoids Determination in Cannabis sativa L. Extracts and
Medicinal Oils
Authors: Silva Sofrás Fresia Melina , Alonso Rosario , Retta Daiana Sabrina , Di Leo Lira Paola , Desimone Martin Federico , van Baren Catalina María
Published: August 2023

Introduction:

Cannabis sativa L. is a well-recognized medicinal plant. Cannabis regulations in Argentina
are insufficient to solve the problem of patient access to full-spectrum cannabis-based products. So, the
market of artisanal products with unknown quality and dosage of cannabinoids is increasing, and so is the local
demand and need for analyzing these products. However, much of the latest validated methodologies for cannabinoid
quantification include expensive instrumentation that is not always available in laboratories of health institutions
in Argentina.

Methods:

The aim of this work was to develop and validate a simple and rapid HPLC-UV method for the identification
and quantification of principal cannabinoids in cannabis resins, inflorescences, and medicinal oils using
standard HPLC equipment. The cannabinoids selected for validation were cannabidiol acid (CBDA), cannabigerol
(CBG), cannabidiol (CBD), cannabinol (CBN), delta-9-tetrahydrocannabinol (Δ9-THC), cannabichromene
(CBC), and tetrahydrocannabinol acid (THCA). A method for the simultaneous identification and
quantification of these 7 main cannabinoids was developed and then validated. Some data parameters were comparable
to other reports with more sophisticated analytical instruments for the analysis of cannabis. The assessed
limits of detection and the limits of quantitation ranged from 0.9 to 3.66 μg/mL and 2.78 to 11.09
μg/mL, respectively. The concentration-response relationship of the method indicated a linear relationship between
the concentration and peak area with R2 values of > 0.99 for all 7 cannabinoids.

Results:

The relative standard deviation (RSD%) varied from 2.34 to 4.82 for intraday repeatability and from
1.16 to 3.15 for interday repeatability. The percentage of recovery values was between 94 to 115% (resins) and
80 to 103% (inflorescence extract). The cannabis industry is growing rapidly, and there is a need for reliable
testing methods to ensure the safety and efficacy of cannabis products. In addition, current methods for cannabinoid
analysis are often time-consuming and expensive, while the HPLC-UV method herein reported is a simple,
rapid, accurate, and cost-effective alternative for the analysis of cannabinoids in cannabis resins, inflorescences,
and medicinal oils.

Conclusion:

This method will be proposed to be included in the Cannabis sativa L. monograph of the Argentine
Pharmacopoeia.
High-Throughput Sequencing Technology Assisted Investigation of the
Correlation Between Intestinal Flora, Serum Biochemistry, Blood Lipids,
and Tumour Markers in Patients with Gastric Cancer and Healthy
Plateau Residents
Authors: Zhou Linghong , Wang Bo , Liu Linxun , Han Pei , Ji Li , Zhang Zilong , Zhang Jingni
Published: August 2023

Aim:

The goal is to use high-throughput sequencing technology to compare and study the structure
and variety of intestinal flora in people with gastric cancer and healthy people in the Qinghai-Tibet Plateau.

Background:

Recent research has connected gut flora structure to numerous disorders. Metabolites,
endotoxins, and immunomodulatory modulation might cause gastrointestinal or other systemic diseases
and affect gastric cancer treatment and prognosis. We used the correlation study to uncover biomarkers
associated with good intestinal flora and gastric cancer groups on the plateau to investigate their involvement
in gastric cancer development.

Objectives:

To investigate the possible links between intestinal flora and gastric cancer in the Qinghai
Plateau region using a variety of clinical phenotypic data and to investigate the flora that may be linked
to gastric cancer.

Methods:

The 22 Qinghai Province tertiary hospital gastric cancer patients and 30 healthy people had
their fresh faeces collected. To examine intestinal flora diversity and composition, 52 patients underwent
16S rDNA high-throughput gene sequencing of intestinal bacteria. The correlation between clinical phenotypes
and the top 15 dominant intestinal flora at the phylum level was analyzed.

Results:

The difference in total protein TP between the healthy group and the gastric cancer group was
statistically significant (P<0.001). Globulin was significantly different (P<0.05), TC of total cholesterol
was significantly different (P<0.05). High-density lipoprotein showed statistical significance
(P<0.05).The difference in low-density lipoprotein was statistically significant (P<0.001). Alphafetoprotein
was significantly different (P<0.05). CA72-4 carbohydrate antigen (P<0.05).

Conclusion:

There were significant differences in total protein, globulin, total cholesterol, high density
lipoprotein, low-density lipoprotein, alpha-fetoprotein and carbohydrate antigen CA72-4 in patients
with gastric cancer in the plateau area compared with the healthy group, and the different clinical variables
were correlated with intestinal flora at some phylum and genus levels.
Anti-Angiogenic Agents Combined with Immunotherapy for Advanced
Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
Authors: Lin Heng , Ma Chenhui , Zhong Aihong , Zang Huanping , Chen Wenxin , Li Lixiu , Le Yuyin , Xie Qiang
Published: August 2023

Background:

Anti-angiogenic agents could enhance tumor immunity response, and anti-
angiogenesis plus immunotherapy has become a novel treatment option for advanced non-small
cell lung cancer (NSCLC). The efficacy of this combination therapy remains controversial and obscure.

Aim:

We conducted a meta-analysis to evaluate the clinical efficacy and safety of this therapeutic
strategy in patients with advanced NSCLC and provide more guidance for treating NSCLC clinically.

Methods:

A systematic literature search was performed in PubMed, Embase, Web of Science,
CNKI, and Wanfang databases to identify relevant studies published up to December 2021. The
primary endpoint was the objective response rate (ORR). Second endpoints were progression-free
survival (PFS), overall survival (OS), and grade ≥3 AEs adverse events (AEs). The sensitivity
analysis was conducted to confirm the stability of the results. STATA 15.0 was utilized for all
pooled analyses.

Results:

Eleven studies were eventually included in the meta-analysis, involving 533 patients with
advanced NSCLC. The pooled ORR rate was 27% (95% CI 18% to 35%; I2 =84.2%; p<0.001),
while the pooled median PFS and OS was 5.84 months (95% CI 4.66 to 7.03 months; I2=78.4%;
p<0.001) and 14.20 months (95% CI 11.08 to 17.32 months; I2=82.2%; p=0.001), respectively.
Most common grade ≥3 AEs included hypertension, hand-foot syndrome, diarrhea, adrenal insufficiency,
hyponatremia, proteinuria, rash, thrombocytopenia, and fatigue.

Conclusion:

Anti-angiogenesis combined with immunotherapy demonstrated satisfactory antitumor
activity and an acceptable toxicity profile in patients with advanced NSCLC. The pooled results
of our meta-analysis provided further evidence supporting the favorable efficacy and safety of
this therapeutic strategy.
Comparative Analysis of Pharmacokinetics and Metabolites of Three Main
Terpenoids before and after Compatibility of Frankincense and Myrrh in Rats by
UHPLC-MS
Authors: Fan Ruo-ying , Gao Ru-meng , Li Jia-shang , Su Shu-lan , Shang Er-xin , Qian Da-wei , Duan Jin-ao
Published: August 2023

Background:

3-acetyl-11-keto-beta-boswellic acid (AKBA) and 11-keto-boswellic acid (KBA) are the
main active components of frankincense as pentacyclic triterpenoids, which are designated by the European Pharmacopoeia
8.0 as the quality standard for the evaluation of Indian frankincense, 2-methoxy-8,12-epoxygermacra-
1(10),7,11-trien-6-one (MCS134) is a non-volatile sesquiterpene compound in myrrh.

Objective:

In this paper, the absorption pharmacokinetics and metabolites of AKBA, KBA and MCS134 after frankincense,
myrrh and their compatibility were analyzed, elaborated their absorption and metabolism mechanism and
provided the ideas for the research on the bioactive components of frankincense and myrrh compatibility in vivo.

Methods:

The area under the blood concentration time curve (AUC), half-life (t1/2) and drug clearance (CL) of
AKBA, KBA and MCS134 in rats were analyzed by LC-TQ / MS. The metabolites of AKBA, KBA and MCS134 in
rats were analyzed by ultra-high pressure liquid chromatography with a linear ion trap-high resolution Orbitrap mass
spectrometry system (UHPLC-LTQ-Orbitrap-MS).

Results:

The results showed that AKBA, KBA and MCS134 reached the maximum plasma concentration at about 2
h, 2 h and 15 min, respectively. AUC0-t and t1/2 of the three components increased in varying degrees after compatibility,
and the clearance/ bioavailability (CL/F) decreased. AKBA, KBA and MCS134 were metabolized in phase I and
phase II in rats, and there represented differences before and after compatibility.

Conclusion:

After the compatibility of frankincense and myrrh, the absorption of effective components was improved
to some extent, and there were some differences in the metabolites in rats. The results provide ideas for elucidating
the in vivo effect mechanism of frankincense and myrrh.
The Development of Stress Reactivity and Regulation in Children and
Adolescents
Authors: Filetti Clarissa , Kane-Grade Finola , Gunnar Megan
Published: August 2023

Adversity experienced in early life can have detrimental effects on physical and mental
health. One pathway in which these effects occur is through the hypothalamic-pituitary-adrenal (HPA)
axis, a key physiological stress-mediating system. In this review, we discuss the theoretical perspectives
that guide stress reactivity and regulation research, the anatomy and physiology of the axis, developmental
changes in the axis and its regulation, brain systems regulating stress, the role of genetic
and epigenetics variation in axis development, sensitive periods in stress system calibration, the social
regulation of stress (i.e., social buffering), and emerging research areas in the study of stress physiology
and development. Understanding the development of stress reactivity and regulation is crucial for
uncovering how early adverse experiences influence mental and physical health.
Cool the Inflamed Brain: A Novel Anti-inflammatory Strategy for the
Treatment of Major Depressive Disorder
Authors: Su Wen-Jun , Hu Ting , Jiang Chun-Lei
Published: August 2023

Background:

Abundant evidence suggests that inflammatory cytokines contribute to the
symptoms of major depressive disorder (MDD) by altering neurotransmission, neuroplasticity, and neuroendocrine
processes. Given the unsatisfactory response and remission of monoaminergic antidepressants,
anti-inflammatory therapy is proposed as a feasible way to augment the antidepressant effect. Recently,
there have been emerging studies investigating the efficiency and efficacy of anti-inflammatory
agents in the treatment of MDD and depressive symptoms comorbid with somatic diseases.

Methods:

In this narrative review, prospective clinical trials focusing on anti-inflammatory treatment
for depression have been comprehensively searched and screened. Based on the included studies, we
summarize the rationale for the anti-inflammatory therapy of depression and discuss the utilities and
confusions regarding the anti-inflammatory strategy for MDD.

Results:

This review included over 45 eligible trials. For ease of discussion, we have grouped them into
six categories based on their mechanism of action, and added some other anti-inflammatory modalities,
including Chinese herbal medicine and non-drug therapy. Pooled results suggest that anti-inflammatory
therapy is effective in improving depressive symptoms, whether used as monotherapy or add-on therapy.
However, there remain confusions in the application of anti-inflammatory therapy for MDD.

Conclusion:

Based on current clinical evidence, anti-inflammatory therapy is a promisingly effective
treatment for depression. This study proposes a novel strategy for clinical diagnosis, disease classification,
personalized treatment, and prognostic prediction of depression. Inflammatory biomarkers are
recommended to be assessed at the first admission of MDD patients, and anti-inflammatory therapy
are recommended to be included in the clinical practice guidelines for diagnosis and treatment. Those
patients with high levels of baseline inflammation (e.g., CRP > 3 mg/L) may benefit from adjunctive
anti-inflammatory therapy.
Role of GLP-1 Receptor Agonist in Diabetic Cardio-renal Disorder:
Recent Updates of Clinical and Pre-clinical Evidence
Authors: Seksaria Sanket , Dutta Bhaskar Jyoti , Kaur Mandeep , Gupta Ghanshyam Das , Bodakhe Surendra H. , Singh Amrita
Published: August 2023

Cardiovascular complications and renal disease is the growing cause of mortality in patients
with diabetes. The subversive complications of diabetes such as hyperglycemia, hyperlipidemia
and insulin resistance lead to an increase in the risk of myocardial infarction (MI),
stroke, heart failure (HF) as well as chronic kidney disease (CKD). Among the commercially
available anti-hyperglycemic agents, incretin-based medications appear to be safe and effective in
the treatment of type 2 diabetes mellitus (T2DM) and associated cardiovascular and renal disease.
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been shown to be fruitful in reducing
HbA1c, blood glucose, lipid profile, and body weight in diabetic patients. Several preclinical and
clinical studies revealed the safety, efficacy, and preventive advantages of GLP-1RAs against diabetes-
induced cardiovascular and kidney disease. Data from cardio-renal outcome trials had highlighted
that GLP-1RAs protected people with established CKD from significant cardiovascular
disease, lowered the likelihood of hospitalization for heart failure (HHF), and lowered all-cause
mortality. They also had a positive effect on people with end-stage renal disease (ESRD) and
CKD. Beside clinical outcomes, GLP-1RAs reduced oxidative stress, inflammation, fibrosis, and
improved lipid profile pre-clinically in diabetic models of cardiomyopathy and nephropathy that
demonstrated the cardio-protective and reno-protective effect of GLP-1RAs. In this review, we
have focused on the recent clinical and preclinical outcomes of GLP-1RAs as cardio-protective and
reno-protective agents as GLP-1RAs medications have been demonstrated to be more effective in
treating T2DM and diabetes-induced cardiovascular and renal disease than currently available
treatments in clinics, without inducing hypoglycemia or weight gain.
Flavonoids from Kalanchoe ×laetivirens Impair Survival and Immunity of
Atta sexdens (Hymenoptera: Formicidae)
Authors: Silva Melo Márcio , Santos Silva Cynthia Lhourrana , Tenório Amanda Caroline  Teles , Silva Melo Bruno , da Silva Barbosa Rone , Sarmento Renato Almeida , Holzbach Juliana Cristina , Barbosa Cruz Állefe , Nascimento Isabele Rodrigues , de Souza Danival José
Published: August 2023

Background:

The active secondary metabolites of various Kalanchoe species are promising for
controlling insects and other agricultural pests.

Objective:

This study aimed to evaluate the mortality and immune responses of the leafcutter ant Atta
sexdens (L.) after treatment with Kalanchoe ×laetivirens (Desc.) aqueous extract. The effects on an
aquatic organism used as a bioindicator, Chironomus xanthus (Rempel), were also evaluated.

Methods:

Different K. ×laetivirens concentrations were prepared by dilution in honey to assess the toxicity
and determine the median lethal concentration (LC50) for A. sexdens workers. The haemocytes of
workers treated with a sublethal concentration (0.005 g/mL) were counted.

Results:

The plant extracts induced high mortality in A. sexdens workers. All concentrations, except 0.001
g/mL, increased mortality rates. The sublethal concentration negatively affected the immune system of A.
sexdens workers 48 and 72 h after ingestion. The flavonoids 4″″-acetylsagittatin A, sagittatin A and the
nucleosides uridine and adenosine were identified. The LC50 of the K. ×laetivirens (128.1 mg /L) was
determined for the non-target organism, C. xanthus.

Conclusion:

These natural compounds can be used in future research to plan alternative control strategies
for leafcutter ants in forests and other agroecosystems.
Chemical Composition and Biological Activities of the Extracts of Peperomia
pellucida Fractions
Authors: Men Tran Thanh , Phien Huynh Hong , Son Nguyen Hoang , Thao Truong Thi Phuong , Nhu Nguyen Thi Bich , Uyen Nguyen Thi To , De Tran Quang , Khang Do Tan
Published: August 2023

Background:

Peperomia pellucida is a medicinal and vegetable plant used worldwide, representing
a multi-purpose vegetable with applications in the pharmaceutical, food and cosmetic industries.

Objective:

This study evaluated the antioxidant, antibacterial, antifungal, anti-inflammatory, and antidiabetic
potential of fractional extracts from P. pellucida plant derived from Can Tho City, Vietnam.

Methods:

Four fractional extracts were prepared using different polarity solvents (hexane, dichloromethane,
ethyl acetate) and used to determine the best extract for each biological property. The fractions’
total alkaloid, phenolic, and flavonoid content were observed. The four extracts were evaluated for their
potential bioactivities: antioxidant, antibacterial, antifungal, anti-inflammatory, and antidiabetic.

Results:

Correspond with the hexane, dichloromethane, ethyl acetate, and aqueous fractions, the total
content of alkaloids was determined to be 255 ± 23.8; 157 ± 14.0; 219 ± 6.55; 221 ± 6.23 (mg AE/g extract),
the total phenolic content was 112 ± 3.34; 141 ± 1.77; 234 ± 29.5; 123 ± 5.04 (mg GAE/g extract),
whereas the total content of flavonoids was 84.49 ± 4.53; 33.77 ± 1.26; 367.8 ± 3.37; 34.49 ± 4.53 (mg
QE/g extract), respectively. The ethyl acetate fraction gave the best efficiency in DPPH, ABTS, iron reduction,
and TAC methods (IC50 = 334 ± 2.10 μg/mL; 51.4 ± 0.41 μg/mL; 79.1 ± 0.40 μg/mL; and 83.0 ±
0.17 μg/mL, respectively). Antibacterial activity was investigated on 5 strains of Bacillus cereus, Escherichia
coli, Staphylococcus aureus, Salmonella typhimunum, Pseudomonas aeruginosa; the results
showed that the extracts were resistant to 5 strains of bacteria, especially best resistant in 2 fractions of
ethyl acetate and aqueous. The minimum inhibitory concentration (MIC) value ranged from 0.5 to 32
mg/mL, while the minimum bactericidal concentration (MBC) value ranged from 16 to 64 mg/mL. The
best anti-inflammatory activity was ethyl acetate with an IC50 value of 216.7 ± 7.2 μg/mL, close to that of
Diclofenac at 205.4 ± 0.5. The antidiabetic activity was investigated based on the ability to inhibit α-
amylase and α-glucosidase enzymes. The results showed that the best α-amylase inhibitors were hexane
and dichloromethane (IC50 = 208.83 ± 2.41 and 191.60 ± 1.27 μg/mL, respectively), roughly equal to the
acarbose (155.68 ± 2.59 μg/mL). The best α-glucosidase inhibitory fraction was ethyl acetate (IC50 of
157.04 ± 0.23 μg/mL), close to that of acarbose (116.45 ± 0.21 μg/mL).

Conclusion:

Fractional extracts from P. pellucida distributed in gardens of Can Tho City, Vietnam, contain
potential antioxidant, antibacterial, antifungal, anti-inflammatory, and antidiabetic bioactive compounds.
A Robust Adaptive Control Strategy for Electro-hydraulic Servo Based on
Friction Compensation
Authors: Yue Luyou , Wang Zhiqing , Huang Hua , Rao Junsen , Zhu Xunyi , Zhang Xinxing , Zhang Bing
Published: August 2023

Background:

The electro-hydraulic servo system has the advantages of high stiffness, fast response speed, high precision and power-to-weight ratio.

Objective:

In this patent, an adaptive robust control strategy based on friction compensation is proposed for insufficient control accuracy due to a large number of nonlinearities and uncertainties in the system.

Methods:

In this patent, the mathematical relationship between the physical quantities of the valve-controlled cylinder is analyzed. Then the mathematical model of valve controlled cylinder considering the main nonlinearity and uncertainty of the system is established. The fuzzy proportion-integral-derivative, deterministic robust, and adaptive robust single-cylinder trajectory tracking controllers are designed and the tracking performance of different reference trajectories is analyzed by MATLAB/Simulink software.

Results:

In this patent, all the three controllers can track the reference trajectories smoothly. Adaptive robust control strategy can make the uncertain parameters of system converge and approach truth value.

Conclusion:

In this patent, the adaptive robust control strategy has the function of online parameter adjustment. When tracking accuracy is taken as the index, its tracking effect is better than fuzzy proportion-integral-derivative and deterministic robust.
Chromenes and Nutraceuticals
Authors: Dwibedi Vagish , Jain Sahil , Mittal Anuradha , Devi Arti , Kaur Walia Harleen , Kumar Rath Santosh , Duran Cuevas Paola Andrea
Published: August 2023

Nutraceuticals have received tremendous interest in the treatment or
prevention of multiple diseases in modern times. Chromenes (Benzopyran),
phytochemicals that are polyphenolic secondary metabolites, are one of the privileged
scaffolds that occur in various natural products as essential structural components and
also have beneficial nutraceutical properties. Chromenes are more correctly referred to
as ‘nutraceuticals' due to their variety of pharmacological activities in the mammalian
body. A better understanding of their mechanisms and biological activities suggests
their ability as therapeutic agents and also for predicting and monitoring food quality
due to their significance in food organoleptic properties and human health. In this
chapter, the discussion will be on the diverse therapeutic actions of chromenes as well
as the probable mechanisms of action that are responsible for their therapeutic activity.
The origins of these chromenes, their extraction from these sources, and their use as
nutraceutical components in various food items will also be discussed. The
pharmacological relevance of chromenes, which may be added to staple foods to create
various nutraceutical products, will also be discussed. As shall be evident after reading
this chapter, chromenes as pharmacological agents have a wide range of targets. As a
result, medicinal chemistry and quantitative structure-activity relationships should be
used to focus on their specific biological action when developing new congeners of
chromenes to be used as drugs.
Chromene and its Derivatives in the Treatment of SARS-COV- 2 Virus Infection
Authors: Ruikar Dipti B. , Joshi Karan , Yadav Rasana , Deshmukh Gajanan J. , Manekar Snehal , Murumkar Prashant R.
Published: August 2023

Coronavirus pandemics are characterizing the 21st century in itself. In 2002-
03, the first coronavirus SARS-CoV caused Severe Acute Respiratory Syndrome
(SARS); in 2012, the Middle East Respiratory Syndrome (MERS-CoV) made its
appearance, and in 2019, a new human beta coronavirus strain, the SARS-CoV-2 led to
COVID-19 pandemic that took over the entire globe under its rollout. The scientific
research and medical challenges to save lives have revealed the biochemistry and
genetic evolution of an important cycle of the new pathogen, which has steered us to
new preventive and therapeutic approaches to treat SARS-CoV-2. Until now, there is a
scant resource of vaccines available, and therefore, it is very challenging to dose huge
mass around the world. Moreover, there are other various difficulties in producing,
distributing, and storing vaccines; the allopathic drug is always a thrust in this situation.
Various in-silico and in-vitro studies have helped to prove that natural molecules
containing chromene have shown their effectiveness in the treatment of SARS-CoV-2.
Pleiotropic activities and the absence of systemic toxicity of natural chromene and its
derivatives represent potential target compounds in clinical trials to enrich the drug
armament against coronavirus infections. In this chapter, efforts are being made to
discuss the recent investigation of the progress of chromenes in treating SARS-COV-2
virus infection and various treatments involving the possible use of poly-substituted
chromene compounds of modern and natural medicines for the treatment of COVID-19.
Chromene as Antioxidants
Authors: Kamal Kant Arya Rajeshwar , Kumar Arun , Guglani Anchala , Bisht Dheeraj , Kumar Deepak
Published: August 2023

Chromene is a heterocyclic compound that contains oxygen in its ring. It is
widely obtained naturally from both animals and plants, and it is an integral part of
alkaloids, tocopherol, anthocyanins, and flavonoids. The 2-oxo-2H-chromene is called
coumarins, and coumarins have excellent antioxidant potential due to the presence of
the phenol group, more than 1300 coumarins have been identified to date. The
chromene scaffold in coumarins has the structural modification ability that makes it the
structure of choice for medicinal purposes. Various medicines can be synthesized by
using a chromene scaffold e.g. asthma, hypertension, antifungal, and antimicrobial.
Chromene shows a good antioxidant potential that depends on its hydrogen ion releasing capacity and stabilizes hydrogen with the help of a high resonating structure.

The bond length between bonds also enhances the free radical scavenging function. In
this chapter, we have discussed some chromene derivatives and their antioxidant
potential, and the effect of cyclic structure on the antioxidant’s function.
Miscellany of Chromene
Authors: Pratim Dutta Partha , Alam Faruk , Kumar Dey Biplab , Tonk Rajeev K.
Published: August 2023

Chromenes (Benzopyran) comprise a major class of pharmacophores widely
distributed in various natural products, synthetic drugs, and therapeutic leads. They
have been able to fascinate scientists due to the diverse pharmacological activities they
possess and the variety of interesting chemical reactions they exhibit. This chapter
critically reviews and highlights the general spectroscopic characteristics of chromenes,
the diversity of naturally available chromenes as well as various strategies and
mechanisms to develop synthetic chromenes. Recent biological application of
chromenes of both natural and synthetic origin is also summarized here.
Synthesis of Carbonaceous Quantum Dots
Authors: Kumar Munish
Published: August 2023

New class of nanocarbon materials, such as luminescent carbon quantum
dots (CQDs) has gained a great deal of interest in the area of electrocatalysis, solar
cells, bioimaging nanomedicine, a chemical sensor and a light-emitting diode. CQDs
exhibit good physio-chemical properties, such as photoluminescence, high
crystallization and good dispersibility. The rapid electron transfer, small size and
superconductivity of CQDs provide the CQDs-based composite offering enhanced
catalytic activity and electric conductivity. However, additional active moieties are
present on the surface, which might aid in the formation of multi-component
electrically activated catalysts. Additionally, the multi-component catalysts' internal
interactions promote charge transfer and catalytic efficiency, both of which are
essential for electrochemistry. Therefore, keeping in mind the importance of CQDs,
they are synthesized on the basis of two approaches: Top-down and Bottom-up. The
bulk material is reduced in size by utilizing chemical and physical processes in the top-down approach. On the contrary, in the bottom-up method, the atoms are assembled
and converted into CQDs using polymerization and carbonization through a chemical
reaction. Hence, in this chapter, we will discuss the synthesis techniques for CQDs,
such as hydrothermal/solvothermal method, laser ablation, arc-discharge method,
acidic oxidation, thermal/combustion routes, electrochemical method and microwave
pyrolysis method.
Characterization of Carbonaceous Quantum Dots
Authors: Thakur Abhinay , Kaur Harpreet , Kumar Ashish , Bashir Sumayah
Published: August 2023

Carbonaceous quantum dots (CQDs), a prominent figure of carbon
materials, offer remarkable impetus in a variety of sectors, including biosensors,
biomedical imaging, drug delivery, photonics, photovoltaics, and electrocatalysis, due
to their distinctive physicochemical, optical, and electrical capabilities. This chapter
attempts to show current advances in CQD characterization, with an emphasis on the
essential multifarious function of CQDs using various techniques, such as
photoluminescence and fluorescence emission spectroscopy. Additionally, with the aim
of developing highly efficient and long-term sustainable CQD-based components, we
explore the obstacles and potential directions of CQD-based substances in this
developing research field.
Application of Quantum Dots in Wastewaters Treatment
Authors: Rai Atma , Kumari Garima , Lima Eder , Sillanpaa Mika , Kumar Nitesh , Guleria Anupam , Kumar Dinesh , Guleria Ashish
Published: August 2023

Water stress and scarcity are among the primary issue that the world is
witnessing in this era, as pollution of freshwater resources are increasing due to various
emerging pollutants, such as pharmaceuticals, personal care products, pesticides, and
household and industrial chemicals. Efficient treatment of wastewater is an important
aspect of fresh water supply, and such water can also be used for different household
activities and other purposes. So for wastewater treatment, different eco-friendly as
well as economic approaches have been analyzed, and the use of carbon quantum dots
(CQDs) for the treatment of wastewater is efficient and effective technique extensively
studied in the last few years. CQDs are promising nanomaterials for water pollution
treatment due to their small particle sizes, tuneable fluorescent properties and
containing oxygen-based functional groups. In this chapter, the chemical and physical
attributes of CQDs, raw substances and methodologies being utilized in the synthesis,
and stability of CQDs, along with their effective employment in wastewater
remediation and treatment, has discussed in detail.
Exploring the interplay of credit and liquidity risks: Impacts on banks’ profitability
Authors: Ben-Ahmed Kais , Kasraoui Naziha , Soulami Asaad
Published: August 2023

This research delves into the intricate relationship between credit and liquidity risks and their far-reaching consequences on the overall profitability of banks. Leveraging a comprehensive dataset comprising 132 observations across twelve distinct financial institutions, spanning the period from 2009 to 2019, the analysis employs a sophisticated empirical framework grounded in simultaneous equations. By incorporating three meticulously chosen control variables, this approach adeptly disentangles the distinct effects of credit and liquidity risks on banks’ financial performance. The methodological trajectory unfolds in a sequential manner, commencing with isolated scrutiny of the individual impacts of credit and liquidity risks on banks’ profitability. This evaluation is gauged through robust metrics such as Returns on Assets and Economics. Subsequently, a nuanced exploration ensues, probing the intricate interplay between these two risks and their combined effect on banks’ profitability. Eminent findings emerge from this investigation, underscoring the adverse consequences of escalated credit risk on bank liquidity, accompanied by a simultaneous elevation in overall risk exposure. This disturbing trend notably casts a substantial shadow over banks’ profitability. Conclusively, this study consistently establishes the detrimental impact of the confluence of credit and liquidity risks on the financial well-being of banks. Evidently, this interaction exerts a negative influence on banks’ profitability, a perspective persistently reinforced by the authors’ analyses. The insights garnered from this study hold notable implications for the banking community and financial practitioners. By enhancing comprehension of the distinct attributes of credit and liquidity risks, this research contributes to a refined understanding of risk management dynamics. Moreover, it accentuates the urgency of fortifying the holistic management of liquidity-credit risks, a call to action that resonates deeply with both bankers and financiers seeking to navigate the intricate terrain of contemporary financial landscapes.
Examining the representation of landscape and its emotional value in German-Swiss fiction between 1840 and 1940
Authors: Grisot Giulia , Herrmann Berenike
Published: August 2023

This paper presents a quantitative analysis of the representation and affective encoding of fictional space in a corpus of 125 Swiss literary prose texts of the 19th and early 20th Century written in German, offering a contribution to both spatial and affective literary studies.

Motivated by questions about the iconic dichotomy between ‘urban’ and ‘rural/natural’ space in literary works (Sengle; Fournier; Nell and Weiland) – and in Swiss literature around 1900 in particular (Rehm) – we use computational methods to detect and examine how different types of space are distributed and affectively encoded in German-Swiss literature. Taking into account the complexity of cultural perceptions and representations of space across history, we examine the presence of ‘urban’ and ‘rural/natural’ fictional spaces and their potential role in constructing a ‘Swiss’ national literature (Böhler; Zimmer), and their affective encoding.

In order to do this, we first compiled a comprehensive dictionary of named and non-named spatial entities in the broad spatial categories RURAL and URBAN, and examined the presence of sentiment and emotions (valence and discrete emotions) and their ‘strength’ (arousal) in relation to these. We used current state-of-the-art sentiment lexicons for German available to the digital humanities community. Similarly to Heuser et al., we mapped the spatial entities and the sentiment lexicons onto our corpus, and focused on spans of +/-50 words around the detected entities, in order to examine the specific sentiment and emotions related to space.

In an exploratory analysis, we offer here a first-time data-driven perspective on rural and urban fictional space, incorporating the dimension of affective encoding of space systematically.
Characteristics of Murta Bast Fiber Reinforced Epoxy Composites
Authors: Kashyap Muneesh , Shillargol Dr. Ranoji K.
Published: August 2023

In daily applications, the composites may also be found. The most prevalent kind of life is concrete. Concrete is a gravel, sand and cement composite material. The main aim of the study is Characteristics of Murta Bast Fiber Reinforced Epoxy Composites. Epoxy resin and HV953U Hardensin from a nearby supplier were purchased and used in accordance with the provision. Bisphénol A diglycidyl ether (BADGE) of the araldite AW106 has an epoxy of the same weight as the eq-1 (203–222 g). Increasing assembly of innovation alone is not enough, especially for composites, to overcome the cost barrier. For composites to be cut through with metals, it is crucial that an integrated application be made in plan, material, measure, tooling, quality verification, production and even programming.
ACCURACY ANALYSIS OF THE CURVED PROFILE MEASUREMENT WITH CMM: A CASE STUDY
Authors: Mazur Tomasz , Rucki Miroslaw , Gutsalenko Yuriy
Published: August 2023

In the paper, analysis of the curved profile measurement accuracy is described. Since there was no CAD model or other reference profile for the measured detail, the first step was to generate the reference contour of the cam using the technical drawing and tolerance requirements. The test campaign consisted of three experiments aimed at determining the effect of scanning velocity on the results of form deviation δ measurement, evaluation of deviation δ measurement uncertainty and the measurement repeatability. The scanning time was checked, too. The obtained results demonstrated feasibility of the chosen CMM and measurement strategy. It was found also that the measurement uncertainty did not depend on the scanning sampling step from 0.05 to 0.2 mm, and the true measurement time was for 30-40% longer than that expected from the nominal scanning velocity.
A GOOD INITIAL GUESS FOR APPROXIMATING NONLINEAR OSCILLATORS BY THE HOMOTOPY PERTURBATION METHOD
Authors: He Ji-Huan , He Chun-Hui , Alsolami Abdulrahman Ali
Published: August 2023

A good initial guess and an appropriate homotopy equation are two main factors in applications of the homotopy perturbation method. For a nonlinear oscillator, a cosine function is used in an initial guess. This article recommends a general approach to construction of the initial guess and the homotopy equation. Duffing oscillator is adopted as an example to elucidate the effectiveness of the method.
Role of narL gene in the pathogenesis of Salmonella Typhimurium
Authors: M PASHUPATHI , Priyadarsini Swagatika , C Nikhil K , Sahoo Pravas Ranjan , Singh Rohit , Saxena Meeta , Upmanyu Vikramaditya , Agarwal Ravikant , Singh Praveen , Saini Mohini , KUMAR AJAY
Published: August 2023

Salmonella Typhimurium (STM) is a facultative anaerobe of zoonotic
importance and one of the causative agents of non-typhoidal
salmonellosis (NTS). During infection, STM must adapt to the changes in
oxygen concentration encountered in the crucial niches of host like gut
lumen and intramacrophage environments. But being a
chemo-organoheterotroph, STM is capable of obtaining its energy from
organic sources via redox reactions. NarL, a transcription factor and
the response regulator of the two-component regulatory system NarX/L,
gets activated under nitrate rich anaerobic condition. Upon activation,
it upregulates the nitrate reduction during anaerobic respiration.
However, in this study, we observed a significant attenuation of
virulence in the narL-knockout strain of STM, while the respective
morphotypes got rescued upon genetic complementation. Along with
motility and biofilm forming ability, the mutant strain displayed
reduced intracellular replication in either intestinal epithelial cells
or monocyte-derived macrophages of poultry origin. Further, in vivo
competitive assay in the murine model showed that wild type STM
significantly outcompeted its isogenic narL null mutant.
Plant diversity effects on belowground multitrophic functioning strengthen with time
Authors: Amyntas Angelos , Gauzens Benoit , Ciobanu Marcel , Warnke Lara , Maraun Mark , Salamon Jörg-Alfred , Merkle Mona , Bassi Leonardo , Hennecke Justus , Lange Markus , Gleixner Gerd , Scheu Stefan , Eisenhauer Nico , Brose Ulrich
Published: August 2023

The relationship of plant diversity and several ecosystem functions
strengthens over time. This suggests that the restructuring of biotic
interactions in the process of a community’s assembly and the associated
changes in function differ between species-rich and species-poor
communities. An important component of these changes is the feedback
between plant and soil community history. In this study, we examined the
interactive effects of plant richness and community history on the
trophic functions of the soil fauna community. We hypothesized that
experimental removal of either soil or plant community history would
diminish the positive effects of plant richness on the multitrophic
functions of the soil food-web, compared to mature communities. We
tested this hypothesis in a long-term grassland biodiversity experiment
by comparing plots across three treatments (without plant history,
without plant and soil history, controls with ~20 years
of plot specific community history). We found that the relationship
between plant richness and belowground multitrophic functionality is
indeed stronger in communities with shared plant and soil community
history. Our findings indicate that anthropogenic disturbance can impact
the functioning of the soil community through the loss of plant species
but also by preventing feedbacks that develop in the process of
community assembly.
The fractions skill score for ensemble forecast verification
Authors: Necker Tobias , Wolfgruber Ludwig , Kugler Lukas , Weissmann Martin , Dorninger Manfred , Serafin Stefano
Published: August 2023

The Fractions Skill Score (FSS) is a neighbourhood verification method
originally designed to verify deterministic forecasts of binary events.
Previous studies employed different approaches to computing an
ensemble-based FSS for probabilistic forecast verification. We show that
the formulation of the ensemble-based FSS substantially affects
verification results. Comparing four different approaches, we determine
how the ensemble-based FSS depends on ensemble size, neighbourhood size,
and frequency of occurrence of the forecast event. Furthermore, we
derive an empirical formula for the expected dependence of the FSS on
ensemble size. Our results are based on high-resolution 1000-member
ensemble precipitation forecasts over Germany for a high-impact weather
period. The large ensemble enables us to study the influence of ensemble
size on forecast skill in terms of a probabilistic skilful spatial
scale. We demonstrate that only one form of ensemble-based FSS, which we
refer to as probabilistic FSS, is well-behaved and exhibits a reasonable
dependence on ensemble size.
Asymptotic expansion of solutions for the Robin-Dirichlet problem of Kirchhoff-Carrier type with Balakrishnan-Taylor damping
Authors: Nhan Huu , Nam Bui , Ngoc Le , Long Nguyen
Published: August 2023

In this paper, we consider the Robin-Dirichlet problem for a nonlinear wave
equation of Kirchhoff-Carrier type with Balakrishnan-Taylor damping. First,
under suitable conditions on the initial data, the local existence and
uniqueness of a weak solution are proved. Next, an asymptotic expansion of
solutions in a small parameter with high order is established. The used main
tools are the linearization method for nonlinear terms together with the
Faedo-Galerkin method, and the key lemmas of the expansion of high-order
polynomials and the Taylor expansion for multi-variable functions.
Finite Gabor systems and uncertainty principle for block sliding discrete fourier transform
Authors: Poumai Khole , Khanna Nikhil , Kaushik S.K.
Published: August 2023

In this paper, we study the finite Gabor system for oversampling schemes. A
characterization of dual finite Gabor tight frame using discrete time Zak
transform is given. Also, a method to calculate the coefficients of the
finite Gabor system expansion in the case of oversampling and a necessary
and sufficient condition for the existence of biorthogonal pair of Riesz
basis in l2(ZL) is given. Further, we introduce the notion of block sliding
discrete Fourier transform (BSDFT) which reduces the computational
complexity and give uncertainty principle for BSDFT. An uncertainty
principle for two finite Parseval Gabor frames in terms of sparse
representations is given. Finally, using the notion of numerical sparsity,
an uncertainty principle for finite Gabor frames is given.
On the continuity of the solution to the Minkowski problem for Lp torsional measure
Authors: Li Ni , Mou Shuang
Published: August 2023

This paper deals with on the continuity of the solution to the Minkowski
problem for Lp torsional measure. For p ? (1, n + 2) ? (n + 2,?), we show
that a sequence of convex bodies in Rn is convergent in Hausdorff metric if
the sequence of the Lp torsional measures (associated with these convex
bodies) is weakly convergent. Moreover, we also prove that the solution to
the Minkowski problem for Lp torsional measure is continuous with respect to
p.
Orlicz-Lacunary bicomplex sequence spaces of difference operators
Authors: Raj Kuldip , Esi Ayhan , Sharma Charu
Published: August 2023

In the present paper we introduce and study some lacunary difference
bicomplex sequence spaces by means of Orlicz functions. We make an effort to
study some algebraic and topological properties of these sequence spaces. We
also show that these spaces are complete paranormed spaces. Further, some
inclusion relations between these spaces and some interesting examples are
established. Finally, we prove some results on modified complex Banach
Algebra in the third section of the paper.
The Josefson-Nissenzweig property for locally convex spaces
Authors: Banakh Taras , Gabriyelyan Saak
Published: August 2023

We define a locally convex space E to have the Josefson-Nissenzweig property
(JNP) if the identity map (E?, ?(E?, E)) ? (E?, ?*(E?, E)) is not
sequentially continuous. By the classical Josefson-Nissenzweig theorem,
every infinite-dimensional Banach space has the JNP. A characterization of
locally convex spaces with the JNP is given. We thoroughly study the JNP in
various function spaces. Among other results we show that for a Tychonoff
space X, the function space Cp(X) has the JNP iff there is a weak* null-sequence (?n)n?? of finitely supported sign-measures on X with unit
norm. However, for every Tychonoff space X, neither the space B1(X) of
Baire-1 functions on X nor the free locally convex space L(X) over X has the
JNP.