bluuebunny/crossref_metadata_2025 huggingface dataset:
Délitement des Liens Sociaux Face à la Distanciation Sociale Imposée par la Pandémie du COVID-19. Essai d’Analyse à Partir du Département de la Menoua (Ouest-Cameroun)
Authors: Trésor Fobasso Guedjo
Published: September 2023

Dans toute société africaine en générale et Camerounaise en particulier où la tradition du salut fraternel est assez forte, les relations de bon voisinage, d’amitié, de complicité et d’amour se trouvent déstabiliser par les règles (20) imposées dans le contexte de confinement. Le fait est que, face à la pandémie du Coronavirus, le principe du mouvement perpétuel qui agite la société camerounaise réside désormais dans la suspicion permanente, source de tensions produite par l’instinct de survie et l’incertitude quant à l’état de santé de l’autre. Le champ social qui se dessine donc à l’horizon au Cameroun est celui d’un espace de lutte pour la préservation de sa santé. Tout ceci laisse place au déploiement d’un ensemble de stratégies visant à restreindre les mouvements et les interactions physiques. De ce fait, cet article vise à analyser les perceptions des nouvelles règles établies dans le contexte de COVID-19, ainsi que leurs effets sur les rapports sociaux.  Dès lors, l’étude a privilégié une démarche qualitative qui mobilise la recherche documentaire, les entretiens individuels et l’observation participante dans la phase empirique. A cet effet, suivant l’approche stratégique et celle des champs, cette étude montre qu’il s’observe désormais au Cameroun un délitement des liens de filiation, de participation élective et de participation organique.

 

In any African society in general and Cameroonian in particular where the tradition of fraternal salvation is quite strong, relations of good neighbourliness, friendship, complicity and love are destabilized by the rules (20) imposed in the context of confinement. The fact is that, in the face of the Coronavirus pandemic, the principle of perpetual movement that agitates Cameroonian society now resides in permanent suspicion, a source of tension produced by the instinct for survival and uncertainty about the health of the other. The social field that is emerging on the horizon in Cameroon is that of a space of struggle for the preservation of one’s health. All this leaves room for the deployment of a set of the strategies aimed at restricting movements and physical interactions. Therefore, this article aims to analyze the perceptions of the new rules established in the context of COVID-19, as well as their effects on social relations.  Therefore, the study favored a qualitative approach that mobilizes documentary research, individual interviews and participant observation in the empirical phase. For this purpose, following the strategic approach and that of the fields, this study shows that it is now observed in Cameroon a breakdown of the links of filiation, elective participation and organic participation.
Onsite Load Bearing Capacity of Curved-up versus Straigt Beams
Authors: Youkhanna Kanaan
Published: September 2023

Straight and curved-up beams are cast as part of the frame models. The models are made as single-span, double-span, and triple-span models. Experimental investigation is conducted to predict load capacity of curved-up beams compared to straight beams. Six models: single-span, double-span and triple-span are presented. Onsite, masonry blocks and bricks, steel pipes and gravel are used to load the beams uniformly. Load is applied gradually until failure mechanism. Enhancement to load capacity is observed in the range between 8.67% to 14.12%. The average enhancement ratio can be taken as 11% due to curved-up effect. Load capacity of interior curved-up beam/span will enhance by 120.3% and 131.3% for both straight and curved-up beams.
Towards Broadcasting Linear Content Over 5G Network
Authors: Shurdi Olimpjon , Lala Algenti
Published: September 2023

Today's society heavily relies on linear television systems featuring planned programs, which serve as a vital means of communication. The evolution of broadcasting linear content is notably driven by advancements in end users' devices. This transition has expanded it from a limited range of linear radio and TV channels to a comprehensive and distinctive array. This selection is accessible across diverse distribution network types. Among these networks, the prominence of the 5G network stands out as a notable platform for media and transmissions. Transmitting linear content over 5G networks involves efficiently delivering scheduled, real-time content to a large number of users simultaneously. This content encompasses live TV broadcasts, radio programs, and streaming events. While 5G networks offer significant advantages in capacity, speed, and latency, it's essential to consider specific factors when it comes to broadcasting linear content. Traditionally, cellular networks, designed for continuous service, have predominantly followed a unicast bidirectional communication paradigm for numerous years, providing a range of services to customers. This paper employs a research methodology to examine the future 3rd Generation Partnership Project (3GPP) 5G Multicast and Broadcast Services (MBS) standards, along with their constraints. Our approach includes a comprehensive literature review, technical specification analysis, and comparison of different broadcasting technologies within the 5G framework. By employing this research methodology, we gain a holistic understanding of the evolving landscape of broadcasting linear content over 5G networks. This contributes to the body of knowledge in this field and informs future advancements in broadcast technologies within the 5G ecosystem.
policial que mata dentro de casa
Authors: Cruz Fernanda
Published: September 2023

Por todo o país tem sido implementadas medidas comprometidas com a prevenção e o combate ao feminicídio. Muitas delas foram criadas ou contam com a participação das instituições de segurança pública. Ao mesmo tempo, pouca atenção tem sido dispensada para entender o comportamento desses profissionais em suas próprias famílias. Pesquisas realizadas em diversos países têm apontado como esses agentes por vezes utilizam de seu poder e ou do conhecimento policial para coagir seus familiares. A partir de um levantamento jornalístico, o artigo analisa 28 casos de mulheres que foram vítimas fatais de seus parceiros profissionais de segurança pública durante o ano de 2021 no Brasil. A análise demonstra que: (a) em metade dos casos analisados após o homicídio o agente cometeu suicídio, (b) a existência de vínculo afetivo anterior ou atual entre o agressor e a vítima, (c) a utilização de armas de fogo na maior parte das mortes, e (d) parte considerável dos casos traziam menções à episódios ou comportamentos violentos prévios.
A PRESENÇA DA CUIA NA POÉTICA DE ROBERTO EVANGELISTA
Authors: Marques Holanda Paulo César , Gonçalves Italo
Published: September 2023

O presente estudo objetivou contextualizar as obras conceituais do artista Roberto Evangelista; e, como especificidade, compreender o cenário da arte conceitual em Manaus, identificando a presença da cuia nas obras do artista e, analisando os possíveis significados deste objeto em duas instalações: Mano-maná das utopias I (1976) e Resgate (1992). Esta é uma pesquisa qualitativa com estudo de caso, de caráter descritivo bibliográfico, utilizando método de interpretação hermenêutico. Compreendendo que a poética está inserida no contexto da arte conceitual da cidade de Manaus, sendo a cuia elemento básico para a intepretação de suas instalações. Para tanto, foi necessário a busca por conceitos inerentes à arte contemporânea e como esta se relaciona com a cultura amazônica. Resultando neste trabalho que visa colaborar com estudos no campo da arte contemporânea na região.
A POÉTICA INTROMETIDA NA EDUCAÇÃO
Authors: Sasso Leísa
Published: September 2023

Em um mundo hiper interativo e em rápida transformação, a Academia também se transforma.  Ainda que de forma relutante, cientistas começam a entender que a subjetividade, a intuição e a criatividade são importantes para a pesquisa científica. Assim sendo, há que se considerar novas formas de pesquisas, novas abordagens, métodos e processos, além de outras formas de comunicação e expressão. Uma dessas formas é a arte, que desafia o paradigma cartesiano e objetivo das universidades. A a/r/tografia, a escrita com arte, a escrita do artista, pesquisador e professor é um exemplo dessa inovação acadêmica. Muitos pesquisadores usam essa escrita para dialogar com seus colegas e com a sociedade, e seguem seu método de Pesquisa Baseada em Arte para atingir seus objetivos de pesquisa. Observada a partir de uma perspectiva educacional, percebe-se que a a/r/tografia também contribui, facilita e induz a compreensão dos fatos e a ampliação do conhecimento em todas as áreas, o que a torna valiosa como pedagogia e, em um sentido mais amplo, como filosofia da educação.
Liturgische Bildung : Systematisierung und Perspektiven aus religionspädagogischer Sicht
Authors: Löhlein Johannes
Published: September 2023

Angesichts der Notwendigkeit liturgischer Bildung verwundert die fehlende Systematisierung dieses Themenfeldes. Insbesondere scheint dies für die religionspädagogische Wissenschaft zuzutreffen. Dies zeigt die Analyse der Forschungsliteratur der vergangenen zwei Jahrzehnte. Entsprechend gilt es, den Diskurs um die liturgische Bildung zu systematisieren und Perspektiven einer zeitgemäßen liturgischen Bildung aufzuzeigen. Liturgische Bildung verfolgt demnach vier aufeinander bezogene Intentionen, deren zentrale Intention die Selbstwerdung des Menschen ist. Ergänzt wird dies um die Intention der tätigen Teilnahme, einer der liturgischen Leitbegriffe des Zweiten Vatikanischen Konzils, sowie den genuinen Beitrag zu einer religiösen Bildung. Die vierte Intention liturgischer Bildung wiederum stellt deren kritisches Potential dar. Liturgische Bildung erfolgt, als weitere Form der Systematisierung, sowohl außerhalb wie innerhalb der Liturgie, wobei die Feier der Liturgie selbst bildend wirkt, was den Fluchtpunkt liturgischer Bildungsbemühungen darstellt. Daraus leitet Johannes Löhlein aus einer religionspädagogischen Sicht ab, dass liturgische Bildung in ihrer theologischen Perspektive vom Menschen her gedacht werden muss. Zugleich liegt für ihn der Beitrag der Religionspädagogik in bibel- und symboldidaktischen Konzepten. Sodann bilden der Kirchenraum sowie die Kasualien Brennpunkte gegenwärtiger liturgischer Bildung.
Does Social Media Marketing Influences Consumer Purchase Decisions at Marketplace?
Authors: Rakhmawati Febri
Published: September 2023

The purpose of this study was to explore the role that social media marketing plays on purchasing decision making process at Shopee marketplace. This research uses quantitative methods using SPSS with simple linear regression. Data collection was obtained by distributing questionnaires online via the Googleform link to 100 respondents. Testing in this study using hypothesis testing using the t test and f test. The results of this study indicate that social media marketing variables have no significant effect on consumer purchasing decisions at Shopee marketplace. Therefore, effective application of social media should be a part of any business’ marketing strategy. For example, social media visuals, content, promotional activities, and use of opinion leader influence should be deployed to positively influence the buying behaviors of consumers. This research brings any managerial implication, especially Shopee management to take concern business marketing strategy to optimize social media marketing impacts on customer in purchasing decisions.
Pengaruh Digital Marketing, Brand Preference dan Product Quality Terhadap Buying Decision Product skincare Avoskin
Authors: Hanifah Nur , Susanti Ari
Published: September 2023

Tujuan dari penelitian ini yakni untuk mengetahui pengaruh digital marketing (pemasaran digital), preferensi merek, dan kualitas produk terhadap keputusan pembelian produk perawatan kulit Avoskin. Penelitian ini menggunakan metode survei dengan objek penelitian yaitu pelanggan kosmetik yang membeli Skincare Avoskin. Pengambilan sampel masyarakat pengguna Avoskin Skincare yang tidak diketahui jumlahnya menggunakan pendekatan purposive sampling dengan jumlah sampel sekitar 100 responden pengguna Avoskin Skincare. Kuesioner digunakan untuk mengumpulkan data.Uji validitas dan reliabilitas digunakan untuk menguji instrumen; uji asumsi klasik meliputi uji normalitas, multikolinearitas, dan heteroskedastisitas; pengujian hipotesis meliputi analisis regresi linier berganda, uji t, uji F, dan uji koefisien determinasi. Hasil analisis data menunjukkan bahwa variable digital marketing (pemasaran digital) memiliki pengaruh yang cukup besar terhadap keputusan pembelian. Telah dibuktikan bahwa preferensi merek memiliki pengaruh besar terhadap Keputusan Pembelian Produk Perawatan Kulit Avoskin. Kualitas Produk pengaruhnya besar terhadap pembelian Produk Avoskin Skincare.Kata Kunci : Marketing, Brand Preference, Product Quality dan Buying Decision
Mandibular Condyle Shape and Symmetry in 4- to 19-Year-Old Children and Early Adolescents
Authors: Bonardo Barnabas , Saskianti Tania , Moeharyono Puteri Mega
Published: September 2023

Background: The prevalence of TMD (temporomandibular disorder) in children and early adolescents varies widely. TMD can cause permanent facial deformities and affect occlusion and speech, which will affect growth, development, and quality of life. For prevention, early detection is needed. However, early detection is often not possible due to a lack of understanding of the normal shape of the condyle. Research on the normal shape of the condyle and symmetry in children and early adolescents has not been much done. Purpose: To evaluate the shape of normal condyles in a population of children and early adolescents aged 4–19 years and determine the most dominant shape and symmetry. Methods: 220 mandibular condyles of 110 children aged 4–19 years (mean 11.4 years) were analyzed retrospectively using an orthopantomograph. Condyle types in primary, mixed, and permanent dentition were categorized according to Yale (convex, rounded, flat, angled) and Chaudhry classification (oval, diamond, bird beak, crooked). Right and left mandibular condyle symmetry was observed according to a previous study by Ribeiro. Results: In primary, mixed, and permanent dentition, the most dominant condyle shapes were (Yale, Chaudhry): 91.6% rounded, 100% oval; 95.8% rounded, 97.9% oval; 98% rounded, 97% oval, respectively. Asymmetry in the right and left mandibular condyles was not found in primary dentition; there were 2 cases in mixed dentition and 3 cases in permanent dentition. Conclusion: In children and early adolescents aged 4–19 years, the normal condyles found are: rounded, convex, angled (Yale), and oval, diamond, or bird beak (Chaudhry). The condyles are dominated by rounded and oval shapes. The incidence of asymmetry in the right and left mandibular condyles probably increases with age.
The Effect of PDLSCs on Orthodontic Tooth Movement – A Review
Authors: Yuliati Yuliati , Kriswandini Indah Listiana , Halim Olivia
Published: September 2023

Background: Stem cells have been widely used in various fields of the health sector, one of which is dental health. Teeth with malocclusion require orthodontic treatment to achieve good function and aesthetics. Orthodontic tooth movement (OTM) occurs due to a bone remodeling process, namely deposition in areas of tension and resorption in areas of pressure. Differentiated stem cells are thought to influence OTM through several different mechanisms. Purpose: This narrative review seeks to explain how stem cells affect the mobility of orthodontic teeth. Review(s): OTM is aided by inflammatory mediators that are produced as a result of the induction of stem cells in the periodontal ligament. These mediators control osteoclast and osteoblast differentiation and proliferation, as well as bone remodeling. Periodontal ligament stem cells (PDLSCs) are important local immune response modulators in the inflammatory milieu and have an impact on a range of immune cells. Conclusion: PDLSCs, which are included in mesenchymal stem cells (MSCs), play a role in OTM through various mechanisms that can cause acceleration in OTM.
The impact of chewing betel nuts on human dentition in Indonesia: A literature review
Authors: Alaydrus Sayf Muhammad , Artaria Myrtati Dyah , Chen Yao-Fong
Published: September 2023

Background: Human behavior can significantly alter dental conditions. One such behavior is the habit of chewing betel nuts. Known as nginang, this tradition holds social significance in many cultures across Indonesia. Societal beliefs include the idea that chewing betel nuts offers a sensation similar to smoking cigarettes, provides a pastime, reduces bad breath, and even enhances dental health. However, evidence shows that it can cause severe damage to teeth. Purpose: This research aims to analyze the literature regarding the impact of chewing betel nuts on dental conditions and to recommend actions to address the problems caused by it. Reviews: While this habit can have positive aspects, it may also cause tooth damage when practiced with a certain frequency and intensity and using specific compositions. Issues such as calculus, periodontitis, attrition, and antemortem tooth loss may occur due to this habit. However, inconsistencies have been found concerning this habit’s relation to caries. Conclusion: A pathological chain reaction triggered by betel nut chewing confirms its detrimental effect on dental health. Further investigations are required to explain the inconsistencies found in this review. The researchers recommend promoting tooth brushing to enable society to maintain its tradition without risking further teeth damage.
Effect of Adding Kinesiotaping to Median Nerve Gliding Exercise Toward Hand Performance of Patients with Carpal Tunnel Syndrome by Using Michigan Hand Outcomes Questionnaire
Authors: Ratih Dwiratna Hakim  , Kesoema Tanti Ajoe , Rahmi Isma Asmara Putri  , Endang Sri Mariani
Published: September 2023

Background: CTS occurs due to local compression of the median nerve with manifestations of neuropathy, mostly in the productive population. Many conservative treatments have been observed to reduce the degree of pain and quality of life in CTS patients. Kinesiotaping is a new therapy that has been widely used for various musculoskeletal conditions and is known for reducing median nerve compression.
Aim: To determine the effect of adding kinesiotaping to median nerve gliding exercise on hand function in CTS patients by using the Michigan Hand Outcomes Questionnaire.
Methods: This research was an experimental randomized pre-and post-test group design. A sample of 24 patients from the Medical Rehabilitation Outpatient in RSUP Dr. Kariadi were divided into two groups randomly. The intervention group (n=12, dropout 1) got kinesiotaping application and median nerve gliding exercise. The control group (n=12, dropout 1) did the median nerve gliding exercise only. Hand performance has been evaluated before and at the end of the 4th week of treatment by using the Michigan Hand Outcomes Questionnaire.
Result: There were significant improvements in the intervention group’s right-hand function (p<0,001), activities of daily living (ADLs) or the ability of the right hand to do certain tasks (p<0,001), work performance (p<0,001), pain (p=0,024), and satisfaction (p<0,001), as compared to the control group. Meanwhile, the intervention and the control group did not show significant differences in left-hand function score (p=0.884), left-hand ability score (p=0.884), and aesthetics score (p=1,000).
Conclusion: There was a positive effect on improving hand performance in CTS patients by adding kinesiotaping to median nerve gliding exercises.
Analisis biaya pasien Severe Cutaneous Adverse Reactions (SCARs)
Authors: Urfiyya Qarriy 'Aina , Fatkhiya Musa Fitri , Perwitasari Dyah Aryani , Febriana Sri Awalia , Supadmi Woro
Published: September 2023

Latar belakang: Severe Cutaneous Adverse Reactions (SCARs) termasuk Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN) dan Drug Reaction with Eosinophilia and Systemic Symptom (DRESS), merupakan reaksi idiosinkratik yang paling sering disebabkan oleh obat yang berdampak pada peningkatan beban keuangan pasien.
Tujuan: Penelitian ini bertujuan untuk mengetahui komponen biaya terbesar dan biaya perawatan pada pasien yang mengalami Severe Cutaneous Adverse Reactions (SCARs).
Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Pengumpulan data biaya medik langsung, biaya non medik langsung dan biaya tidak langsung pada pasien rawat inap dengan SJS, TEN dan DRESS di RSUP Dr. Sardjito Yogyakarta tahun 2014-2018, secara retrospektif. Kami menghitung komponen biaya tertinggi dan biaya perawatan pasien dengan SCARs berdasarkan perspektif masyarakat.
Hasil: Komponen biaya tertinggi pada pasien SJS dan TEN adalah biaya jasa profesional kesehatan (24,1% and 25,2%), sedangkan komponen biaya tertinggi pada pasien DRESS adalah biaya obat (20,2%). Total biaya perawatan 47 pasien SCARs (22 pasien SJS, 6 pasien TEN, dan 19 pasien DRESS) adalah Rp 666.615.321, dengan biaya rata-rata tertinggi pada pasien TEN, diikuti SJS dan DRESS (Rp 16.510.595, Rp 14.205.545, and Rp 13.445.555)
Kesimpulan: Komponen biaya terbesar adalah biaya jasa professional kesehatan pada pasien SJS dan TEN, serta biaya obat bagi pasien DRESS. Penatalaksanaan SCARs membutuhkan biaya yang cukup besar, dan masih menjadi beban keuangan bagi pasien.
Potensi Enzim Superoksida Dismutase dari Biji Jagung (Zea Mays L.) untuk Perbaikan Sel Fibroblas 3t3 Yang Dipaparkan Sinar Ultraviolet A
Authors: Pratiwi Mustika Endah , Peranginangin Jason Merari , Asiya Isna Jati , Indrayati Ana
Published: September 2023

Latar belakang: Radiasi sinar UV-A memicu gangguan pada kulit yang disebut fotoaging. Fotoaging ditangani dengan zat antioksidan. SOD merupakan antioksidan enzimatis lini pertama dalam penanganan radikal bebasTujuan: Tujuan dari penelitian ini adalah untuk mengetahui aktifitas antifotoaging ekstrak SOD biji jagung pada sel fibroblas 3T3 yang dipaparkan sinar UV-A.Metode: Ekstraksi SOD biji jagung dilakukan menggunakan metode sentrifugasi, presipitasi dan dialisis. Aktivitas SOD dari ekstrak SOD biji jagung dilakukan dengan menggunakan metode WST-1. Aktivitas antifotoaging ekstrak SOD biji jagung dilakukan pada sel fibroblas 3T3 yang dipaparkan sinar UV-A dengan parameter viabilitas sel. Pengujian aktivitas antifotoaging menggunakan kontrol sel, kontrol negatif, sampel dan kontrol positif. Hasil pengukuran aktivitas antifotoaging ekstrak SOD biji jagung dianalisis menggunakan One Way ANOVA dengan uji Tukey.Hasil: Persen inhibisi aktivitas SOD tertinggi yaitu pada ekstrak SOD biji jagung presipitasi amonium sulfat konsentrasi 60-90%. Aktivitas antifotoaging ekstrak SOD biji jagung menunjukkan perbedaan bermakna pada nilai persen viabilitas sel pada sel fibroblas antara kelompok ekstrak dengan kelompok kontrol negatif dengan hasil persen viabilitas sel tertinggi yaitu pada ekstrak SOD biji jagung konsentrasi 100 mg/ml. Nilai EC90 untuk parameter viabilitas sel yaitu sebesar 12,57 mg/ml dan 69,47 mg/ml.Kesimpulan: Ekstrak SOD dari biji jagung terbukti memiliki aktivitas sebagai antioksidan yang dapat digunakan sebagai anti fotoaging melalui mekanisme perbaikan sel fibroblast.Kata kunci : Biji jagung, antifotoaging, kolagen, SOD, sel fibroblas 3T3
Validation and development of UV-Vis spectrophotometer analysis methods for alpha-tocopherol acetate
Authors: Iman Arif Al , Auli Winni , Sukrasno Sukrasno
Published: September 2023

Background: The COVID-19 pandemic had caused the consumption of vitamins in the community to increase with the aim of maintaining immunity in the body. Objective: This study aims to develop an analysis method with a UV-Vis spectrophotometer, which is considered an alternative analysis method that is easier, more practical, and cheaper. Method: Methods for analyzing alpha-tocopherol acetate are validated through specificity tests, linearity measurements, precision tests, accuracy tests, determination of detection limits, determination of quantitation limits, and determination of range using ethanol p.a solvent and UV-Vis Spectrophotometer instruments. Then, examine the alpha tocopherol acetate content of vitamin E dietary supplements. Results: The specificity test showed that matrix had no significant effect on the analysis, the linearity test met the requirements with a concentration range of 20–60 ug/mL (r = 0.9991), the accuracy test was 99.897-100.315%, intraday and interday precision tests were obtained with %RSD less than 2%, the LOD value was 1.859 ug/mL and the LOQ value was 5.635 ug/mL. The determination of levels of vitamin E in dietary supplements showed levels for brand A of 100.508% and brand B of 100.089%. Conclusion: The analytical method developed had met the validation requirements, and the levels of vitamin E food supplements had met the USP requirements. Keywords: method validation, UV-Vis spectrophotometer, alpha tocopherol acetate
VALUES OF RELIGIOUS MODERATION IN THE BOOK OF ISLAM THE CENTRAL WAY BY YUSUF QARDHAWI
Authors: Fikri Abdul , Susilo Mohamad Joko
Published: September 2023

The social conditions of society in recent years have experienced various phenomena of intolerance that have given rise to different extreme, exclusive, and radical understandings. Some of these incidents are caused by narrowing and deviations in the knowledge of Islam. This study aims to determine the values of religious moderation in the book Islam The Central Way by Yusuf Qardhawi. Qualitative research uses a library research approach with the book Islam Jalan Tengah as a primary reference. Data collection using documentation study techniques. Data analysis techniques are carried out descriptively through data reduction, data display, and concluding stages. The results of this study concluded that the Values of Religious Moderation contained in the book Islam Jalan Tengah by Yusuf Qardhawi include: comprehensive values, relevance values, wisdom, universal values, adequacy values, and historical exploratory values.
‘If Our Love Existed in Chinese Tense’: Temporal Tensions in Xiaolu Guo’s A Concise Chinese-English Dictionary for Lovers
Authors: Foo Carissa
Published: September 2023

This article is a close textual reading of Xiaolu Guo’s A Concise Chinese-English Dictionary for Lovers (2007). In the novel, the protagonist Z confesses she is not good at tenses. Her uncertain command of temporality transposes from the context of grammatical tense to her love life, where her desire to forever be with her English partner conflicts with his belief that the future is not in the present. As her language learning struggles mirror the widening fissures in her relationship, temporal tensions arise. For one, Z’s first language (Chinese) does not have tenses, while her second (English) is dominated by time-sensitive verbs. This article is interested in the temporal tensions (time as linear or as looping) that illuminate the cultural and linguistic factors affecting Z’s perception of love, and reveal the gendered power structure (her male partner’s dominance over Z’s female subservience) that steers the relationship. Her ruminations on love and efforts at making sense of tenses draw together an ideographic scripting of a kind of love that deprioritises temporality to counteract the discipline and development of love in a linear time culture. Love in ‘Chinese tense’, as Z desires, is one that defies progression, future-proofed and faithful as a picture is unchanging.
Exploiting TLK1 and Cisplatin Synergy for Synthetic Lethality in Androgen-Insensitive Prostate Cancer
Authors: Bhoir Siddhant , Ogundepo Oluwatobi , Yu Xiuping , De Benedetti Arrigo
Published: September 2023

Cellular organisms possess intricate DNA damage repair and tolerance pathways to manage various DNA lesions arising from endogenous or exogenous sources. Dysregulation of these pathways is associated with cancer development and progression. Synthetic lethality (SL), a promising cancer therapy concept, involves exploiting the simultaneous functional loss of two genes for selective cell death. PARP inhibitors (PARPis) have demonstrated success in BRCA-deficient tumors. Cisplatin (CPT), a widely used chemotherapy agent, forms DNA adducts and crosslinks, rendering it effective against various cancers but less so for prostate cancer (PCa) due to resistance and toxicity. Here, we explore the therapeutic potential of TLK1, a kinase upregulated in androgen-insensitive PCa cells, as a target for enhancing CPT-based therapy. TLK1 phosphorylates key homologous recombination repair (HRR) proteins RAD54L and RAD54B, critical for HRR alongside RAD51. The combination of CPT with TLK1 inhibitor J54 exhibits SL in androgen-insensitive PCa cells. The formation of double-strand break intermediates during inter-strand crosslink processing necessitates HRR for effective repair. Therefore, targeting TLK1 with J54 enhances the SL of CPT by impeding HRR, leading to increased sensitivity in PCa cells. These findings suggest a promising approach for improving CPT-based therapies in PCa, particularly in androgen-insensitive cases. By elucidating the role of TLK1 in CPT resistance, this study provides valuable insights into potential therapeutic targets to overcome PCa resistance to CPT chemotherapy. Further investigations into TLK1 inhibition in combination with other DNA-damaging agents may pave the way for more effective and targeted treatments for PCa and other cancers that exhibit resistance to traditional chemotherapy agents.
Physico-Chemical Properties and Phosphorus Solubilization of Organomineral Fertilizers Derived From Sewage Sludge
Authors: Espinoza Andre Luiz de Freitas , Raniro Henrique Rasera , Leite Camille Nunes , Pavinato Paulo Sergio
Published: September 2023

Sewage sludge is an organic waste generated in waste-water treatment plants with certain content of nutrients, what may potentially be used as a source of slow release fertilizer, especially as phosphorus (P) source, but it demands some pre-treatment and the content of P is much lower compared to soluble mineral fertilizers. For these reasons, composted sewage sludge was used to manufacture pelletized organomineral fertilizers, mixing it with the inorganic sources monoammonium phosphate (MAP) and AshDec® (ASD) (thermochemically incinerated sewage sludge). The fertilizers were physiochemically characterized and evaluated as to the dynamics of soil P solubilization, and the forms of P remaining according to its lability. The sources evaluated were: organic compost of sewage sludge powder (SSC), pelletized SSC (SCP), pelletized organominerals SSC+MAP (S+MAP) and SSC+ASD (S+ASD), ASD alone, all compared to a soluble mineral fertilizer (MAP), and a control without P fertilizer. A test was conducted in leaching columns with 50 g of soil (Oxisol), where the fertilizers were applied at a dose of 100 mg P/column, and 30 mL of water or 2% citric acid were added daily for 30 consecutive days. The collected leachates had pH measured and P content determined. Pelletizing process resulted in denser products and promoted more gradual P release. The organomineral S+MAP was the most water-soluble recycled source, solubilizing about 70% of the total P, while the others presented much lower solubilization (<20%). In contrast, all fertilizers showed high solubility in 2% citric acid (except for S+ASD). After leaching, the greatest amount of P remaining in the soil as labile and moderately labile. Composting and the AshDec process produced materials with slow P solubilization, which would be favoured to solubilize in acidic soils and acidic rhizosphere conditions. In turn, the organomineral mixture of SSC with a highly soluble mineral fertilizer (MAP) resulted in a promising product with intermediate nutrient solubility, better synchronized with crop demand, thus increasing efficiency in P use.
Urban Agriculture and Health in Africa. A Review
Authors: Konou Akuto Akpedze , Kemajou Mbianda Armel Firmin , Munyaka Baraka Jean-Claude , Chenal Jérôme
Published: September 2023

Urban agriculture is an early practice, especially for cities in the Global South that are expanding at an unprecedented rate, and in African cities, it can be a way to attend to essential social and health needs. However, it is unclear whether architects and urban planners have expressed interest or already incorporated urban farming within their designs of African cities. This literature review was conducted to understand to what extent architects and urban planners have researched urban agriculture and health. Comprehensive searches based on urban agriculture, health, and Africa were conducted in Scopus, PubMed, and Web of Science from 2000 to December 2020. Zotero, Mozilla Firefox search engine, and Google Chrome were used to collect paper metadata. The duplicate articles were excluded, and all the n = 240 publications remaining were included in the analysis. Food security and the immediate health impact of urban agriculture on health were the most addressed topics. These studies reported the harmful effects of urban agriculture on malaria and the wastewater irrigation of plants. The evidence on urban agriculture is increasing from public health researchers, but not in the field of urban planning or architecture. Future research on urban agriculture's impacts on urban health should be increasingly done by architects and planners to help shape urban planning practices and regulations that could help create urban agriculture that benefits urban health.
Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions
Authors: Fajemiroye James Oluwagbamigbe , Moreira Andre Luis Elias , Ito Célia , Costa Elson Alves , Queiroz Rafaella Misael , Ihayi Ogbu John , Moreira Caroline Vitória , Costa Rafael Fernandes , Teixeira Claudia Carneiro , Bortolini Miguel Junior Sordi , Silva Osmar Nascimento
Published: September 2023

Syphilis continues to be a significant global health concern, and understanding the latest advancements in immunology and pharmacological treatment is crucial for effective disease management. This review article provides an in-depth exploration of these advancements, aiming to contribute to the growing body of knowledge on syphilis research. The epidemiology of syphilis sets the stage for this review, highlighting the persistent burden of the disease worldwide. Current trends and challenges in disease control are discussed, shedding light on the need for comprehensive prevention strategies and improved surveillance systems. The immunological aspects of syphilis are the focus of this review. The intricate interplay between the host immune response and the evasive strategies employed by Treponema pallidum, the causative agent of syphilis, are explored. These include the mechanisms of immune evasion, the role of adaptive and innate immunity, and the development of immune-mediated tissue damage. The article also highlights advancements in diagnostic methods, with emphasis on the importance of accurate and timely detection. From traditional serological tests to the emergence of novel molecular and point-of-care assays, these developments have significantly improved the efficiency and accuracy of syphilis diagnosis. In terms of pharmacological treatment, the review covers the current recommendations and emerging strategies for managing syphilis infections. The challenges posed by antimicrobial resistance are addressed, emphasizing the importance of appropriate treatment regimens and close monitoring of therapeutic efficacy. Looking to the future, this review highlights the potential of vaccine development as a preventive measure against syphilis. Promising vaccine candidates and ongoing research efforts are discussed, offering hope for an effective means of disease prevention. In conclusion, this comprehensive review explores the advancements in syphilis research, from the understanding of immunological complexities to the development of innovative treatment strategies. By collectively advancing our knowledge, we can strive towards better disease management and minimize the impact of syphilis on global public health.
History and Prospects for Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines
Authors: Rustia Jessica M , Antonino Judith P , Velasco Ravelina R , Lima Marcelo A , Yates Edwin A , Fernig David G
Published: September 2023

The windowpane oyster Placuna placenta, lives in brackish coastal waters and has long been economically important to the Philippines because of its durable and translucent shell, which is used as a glass substitute and material for making windowpanes and handicrafts. There has been considerable degradation of the windowpane oyster fishery in past decades. Moreover, there are waste and under-exploited by-products such as the meat, which though nutritious and edible, currently has a very low value; its use being confined to dishes consumed by families in the fishing community. Historically there are instances of excellent practice in terms of regulating the windowpane oyster fishery, while in recent times there have been local initiatives to restore this and to develop high value food products from the meat. These initiatives have, however, never been followed through at a provincial or national level. Research on other molluscs and marine organisms highlights that these also contain high value pharmaceutical products. This review compiles evidence to establish the groundwork for an essential and comprehensive multidisciplinary research program centred around the windowpane oyster, which would ensure a high value for all parts of the oyster, including those currently discarded. By fostering a sustainable and circular economy within this fishery sector and its associated industry, its economic value would be amplified. This is particularly important for oyster harvesters in the Philippines, who often find themselves at the economic ladder's lower rungs. By integrating the principles of a circular economy, this initiative would not only aim to uplift the economic prospects of these harvesters but in doing so would drive the restoration of the windowpane oyster to its former range.
Creating a Mentoring Culture: Cultivating Leadership Potential in Faculty and Staff
Authors: Hozien Wafa
Published: September 2023

Recent years have seen organizations increasingly shift towards the development of a mentoring culture, as opposed to the imposition of formalized mentoring programs. This original research paper set out to explore the utility of fostering mentoring cultures within higher education settings with a particular emphasis placed on the ways in which a mentoring culture may support the nurturing of leadership potential and serve underrepresented minority faculty and staff members. Primary data was gathered using an open-ended qualitative survey, which was followed up by semi-structured interviews. One hundred faculty members in diverse academic and administrative leadership roles across the United States were sent online surveys, with 18 individuals expressing interest in participating in a semi-structured interview. Those who responded affirmatively were then contacted via telephone to follow up with further questions. Analysis of their insights, in conjunction with analysis of other literature, suggests that the cultivation of a mentoring culture offers diverse benefits for mentees advancing into leadership positions; for mentors; and for the institution as a whole. Overall, the development of a mentoring culture characterized by informal, spontaneous exchanges, and tailored to the needs of underrepresented minority faculty members, appears to be a useful tool in enhancing leadership potential in higher education contexts.
Identifying Urban Park Events through Computer Vision-Assisted Categorization of Publicly-Available Imagery
Authors: Tan Yizhou , Li Wenjing , Chen Da , Qiu Waishan
Published: September 2023

Understanding park events and their categorization offer pivotal insights into urban parks and their integral roles in cities. This study utilized images and event category data from the New York City Parks Events Listing database to train a Convolutional Neural Network (CNN) for image-based park event categorization. Different CNN models were tuned to complete this multi-label classification task, their performances compared. Preliminary results underscore the efficacy of deep learning in automating the event classification process, revealing the multifaceted activities within urban green spaces. The CNN showcased proficiency in discerning various event nuances, emphasizing the diverse recreational and cultural offerings of urban parks. Such categorization has potential applications in urban planning, aiding decision-making processes related to resource distribution, event coordination, and infrastructure enhancements tailored to specific park activities.
Emerging Techniques for the Study of Microglia: Visualization, Depletion and Fate Mapping
Authors: Bobotis Bianca , Halvorson Torin , Carrier Micaël , Tremblay Marie-Ève
Published: September 2023

The central nervous system (CNS) is an essential hub for neuronal communication. As a major component of the CNS, glial cells are vital in the maintenance and regulation of neuronal network dynamics. Research on microglia, the resident innate immune cells of the CNS, has advanced considerably in recent years, and our understanding of their diverse functions continues to grow. Microglia play critical roles in the formation and regulation of neuronal synapses, myelination, responses to injury, neurogenesis, inflammation and many other physiological processes. In parallel with advances in microglial biology, cutting-edge techniques for the characterization of microglial properties have emerged with increasing depth and precision. Labeling tools and reporter models are important for the study of microglial morphology, ultrastructure and dynamics, but also for microglial isolation, which is required to glean key phenotypic information through single-cell transcriptomics and other emerging approaches. Strategies for selective microglial depletion and modulation can provide novel insights into microglia-targeted treatment strategies in models of neuropsychiatric and neurodegenerative conditions, cancer and autoimmunity. Finally, fate mapping has emerged as an important tool to answer fundamental questions about microglial biology, including their origin, migration and proliferation throughout the lifetime of an organism. This review aims to provide a comprehensive discussion of these emerging techniques, with applications to the study of microglia in development, homeostasis and CNS pathologies.
Chemical Characteristics and Controlling Factors of Shallow Groundwater in the Lower Reaches of Changhua River Basin, Hainan Island, China
Authors: Wang Dun , Zhang Li zhong , Pei Li xin , Li Xi wen , Yang Ya min , Chen Ze heng , Liang Lin de
Published: September 2023

The lower reaches of the Changhua River are located in the northwest of Hainan Island, and the shallow groundwater in this area is the main water source for residents living at both sides of the river. In order to sustain the exploitation and use of water resources in this area, it is essential to clarify the chemical characteristics and the formation mechanism of the groundwater. We collected 100 sets of shallow groundwater samples from the lower reaches of the Changhua River, and analyzed the chemical characteristics of the groundwater in shallow aquifers as well as its controlling factors by means of the methods including descriptive statistical analysis, Piper diagram, Gibbs diagram, and ion ratio. The results show that the overall characteristics of groundwater in the study area are near-neutral to weakly alkaline nature, indicating a generally oxidized environment. The groundwater involves in 56 chemical types, and the most predominant types are Ca•Na-HCO3 and Ca-HCO3, respectively. NO- 3 has become a macro component exceeding SO2- 4in most of the sampling groundwater, suggesting a significant impact of human activities in this area. At the same time, the chemical characteristics of groundwater in the study area are mainly affected by the water-rock interaction, while the water-rock interaction is mostly affected by the dissolution of silicate rocks and less by the dissolution of carbonate rocks and evaporite rocks. According to the ion ratio results, Na+ and K+ in the study area are mainly from the leaching of silicate rocks, Ca2+ and Mg2+ are mainly from the dissolution of carbonate rocks, in addition to a certain degree of cationic exchange. NO- 3 is mainly related to human activities, and the human activities are more affected by agricultural activities and domestic sewage than by industrial and mining activities. This study can provide a reference for the development and protection of shallow groundwater in the lower reaches of the Changhua River.
Personalized Arrhythmic Risk Stratification for Sudden Cardiac Death in Ischemic, Non-ischemic, and Hypertrophic Cardiomyopathy Patients: The Two-Step, Non-invasive Risk Factors Guiding to Electrophysiology Study Approach
Authors: Arsenos Petros , Kordalis Athanasios , Dilaveris Polychronis , Doundoulakis Ioannis , Antoniou Christos-Konstantinos , Laina Aggeliki , Milaras Nikias , Xintarakou Anastasia , Tsiachris Dimitris , Sideris Skevos , Toutouzas Konstantinos , Tsioufis Konstantinos , Gatzoulis Konstantinos A
Published: September 2023

Arrhythmic sudden cardiac death (SCD) has an annual prevalence of 1 per 1000 while 75% of the victims suffer from ischemic and 10% from non-ischemic or hypertrophic cardiomyopathy. Altogether, these three entities account for more than 80% of the total SCD victims. Guidelines for implantable cardiac defibrillators are still dominated by LVEF<30% from the MADIT II study. In terms of arrhythmic risk stratification, the PRESERVE-EF study restored in clinical practice the two-step arrhythmic risk stratification approach based on Electrocardiographic non-invasive risk factors (NIRFs) guiding to electrophysiological study. In our times with the multiple cardiac imaging methods and artificial intelligence applications availability, this two-step approach based on integrated arrhythmia mechanisms detection, emerges as an efficient SCD risk stratification paradigm for these three entities but also for the patients with congenital heart disease.