bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application
Authors: Hu Yun-Yun , Yang Gang , Liang Xue-Song , Ding Xuan-Si , Xu De-En , Li Zhe , Ma Quan-Hong , Chen Rui , Sun Yan-Yun
Published: March 2023

Transcranial ultrasound stimulation is a neurostimulation technique that has gradually attracted the attention of researchers, especially as a potential therapy for neurological disorders, because of its high spatial resolution, its good penetration depth, and its non-invasiveness. Ultrasound can be categorized as high-intensity and low-intensity based on the intensity of its acoustic wave. High-intensity ultrasound can be used for thermal ablation by taking advantage of its high-energy characteristics. Low-intensity ultrasound, which produces low energy, can be used as a means to regulate the nervous system. The present review describes the current status of research on low-intensity transcranial ultrasound stimulation (LITUS) in the treatment of neurological disorders, such as epilepsy, essential tremor, depression, Parkinson's disease (PD), and Alzheimer's disease (AD). This review summarizes preclinical and clinical studies using LITUS to treat the aforementioned neurological disorders and discusses their underlying mechanisms.
Associations of mTBI and post-traumatic stress to amygdala structure and functional connectivity in military Service Members
Authors: Gimbel Sarah I. , Wang Cailynn C. , Hungerford Lars , Twamley Elizabeth W. , Ettenhofer Mark L.
Published: March 2023

Introduction

Traumatic brain injury (TBI) is one of the highest public health priorities, especially among military personnel where comorbidity with post-traumatic stress symptoms and resulting consequences is high. Brain injury and post-traumatic stress symptoms are both characterized by dysfunctional brain networks, with the amygdala specifically implicated as a region with both structural and functional abnormalities.

Methods

This study examined the structural volumetrics and resting state functional connectivity of 68 Active Duty Service Members with or without chronic mild TBI (mTBI) and comorbid symptoms of Post-Traumatic Stress (PTS).

Results and discussion

Structural analysis of the amygdala revealed no significant differences in volume between mTBI and healthy comparison participants with and without post-traumatic stress symptoms. Resting state functional connectivity with bilateral amygdala revealed decreased anterior network connectivity and increased posterior network connectivity in the mTBI group compared to the healthy comparison group. Within the mTBI group, there were significant regions of correlation with amygdala that were modulated by PTS severity, including networks implicated in emotional processing and executive functioning. An examination of a priori regions of amygdala connectivity in the default mode network, task positive network, and subcortical structures showed interacting influences of TBI and PTS, only between right amygdala and right putamen. These results suggest that mTBI and PTS are associated with hypo-frontal and hyper-posterior amygdala connectivity. Additionally, comorbidity of these conditions appears to compound these neural activity patterns. PTS in mTBI may change neural resource recruitment for information processing between the amygdala and other brain regions and networks, not only during emotional processing, but also at rest.
Improvement of semantic processing ability of Chinese characters in school children: A comparative study based on 2009 and 2019 data
Authors: Zhang Qinfen , Dong Xuan , Song Yan , Wang Chaoqun , Ji Shiyan , Mei Haitian , Wang Rui
Published: March 2023

To explore the characteristics of semantic cognitive development of school children by observing the development changes over 10 years, a retrospective event-related potential (ERP) study was conducted on the semantic processing characteristics of Chinese characters in children aged 7–11 years with the same study design in 2009 and 2019. For the EEGs recorded in 2009, the N400 amplitude of semantic processing in children aged 7–11 years showed an approximately inverted U-shaped development trend with a slow rise at the age of 7–9, a peak at the age of 10, then a rapid decline at the age of 11. However, for the EEGs recorded in 2019, the N400 amplitude showed a gradually decreasing development trend with a slow decline for the 7–11 years class. Our data suggested that the semantic processing of Chinese characters in children aged 7–11 years in 2019 was one age stage earlier than that in 2009. The children’s brain cognition is in the process of development and change with high plasticity. 10 years of favorable social and educational environmental factors have significantly improved children’s semantic processing ability of Chinese characters.
High-accuracy deep ANN-to-SNN conversion using quantization-aware training framework and calcium-gated bipolar leaky integrate and fire neuron
Authors: Gao Haoran , He Junxian , Wang Haibing , Wang Tengxiao , Zhong Zhengqing , Yu Jianyi , Wang Ying , Tian Min , Shi Cong
Published: March 2023

Spiking neural networks (SNNs) have attracted intensive attention due to the efficient event-driven computing paradigm. Among SNN training methods, the ANN-to-SNN conversion is usually regarded to achieve state-of-the-art recognition accuracies. However, many existing ANN-to-SNN techniques impose lengthy post-conversion steps like threshold balancing and weight renormalization, to compensate for the inherent behavioral discrepancy between artificial and spiking neurons. In addition, they require a long temporal window to encode and process as many spikes as possible to better approximate the real-valued ANN neurons, leading to a high inference latency. To overcome these challenges, we propose a calcium-gated bipolar leaky integrate and fire (Ca-LIF) spiking neuron model to better approximate the functions of the ReLU neurons widely adopted in ANNs. We also propose a quantization-aware training (QAT)-based framework leveraging an off-the-shelf QAT toolkit for easy ANN-to-SNN conversion, which directly exports the learned ANN weights to SNNs requiring no post-conversion processing. We benchmarked our method on typical deep network structures with varying time-step lengths from 8 to 128. Compared to other research, our converted SNNs reported competitively high-accuracy performance, while enjoying relatively short inference time steps.
Isolation and characterization of a novel hydrolase-producing probiotic Bacillus licheniformis and its application in the fermentation of soybean meal
Authors: Qi Nanshan , Zhan Xiaoshu , Milmine Joshua , Sahar Maureen , Chang Kai-Hsiang , Li Julang
Published: March 2023

Soybean meal (SBM) is one of the most important sources of plant-based protein in the livestock and poultry industry. However, SBM contains anti-nutritional factors (ANFs) such as glycinin, β-conglycinin, trypsin inhibitor and phytic acid that can damage the intestinal health of animals, inevitably reducing growth performance. Fermentation using microorganisms with probiotic potential is a viable strategy to reduce ANFs and enhance the nutritional value of SBM. In this study, a novel potential probiotic Bacillus licheniformis (B4) with phytase, protease, cellulase and xylanase activity was isolated from camel feces. The ability of B4 to tolerate different pH, bile salts concentrations and temperatures were tested using metabolic activity assay. It was found that B4 can survive at pH 3.0, or 1.0% bile salts for 5 h, and displayed high proliferative activity when cultured at 50°C. Furthermore, B4 was capable of degrading glycinin, β-conglycinin and trypsin inhibitor which in turn resulted in significant increases of the degree of protein hydrolysis from 15.9% to 25.5% (p < 0.01) and crude protein from 44.8% to 54.3% (p < 0.001). After fermentation with B4 for 24 h, phytic acid in SBM was reduced by 73.3% (p < 0.001), the neutral detergent fiber (NDF) and the acid detergent fiber of the fermented SBM were significantly decreased by 38.40% (p < 0.001) and 30.20% (p < 0.05), compared to the unfermented SBM sample. Our results suggested that the effect of solid-state fermented SBM using this novel B. licheniformis (B4) strain, could significantly reduce phytic acid concentrations whilst improving the nutritional value of SBM, presenting itself as a promising alternative to phytase additives.
Therapeutic advances in leiomyosarcoma
Authors: Lacuna Kristine , Bose Sminu , Ingham Matthew , Schwartz Gary
Published: March 2023

Leiomyosarcoma is an aggressive mesenchymal malignancy and represents one of the most common subtypes of soft tissue sarcomas. It is characterized by significant disease heterogeneity with variable sites of origin and diverse genomic profiles. As a result, the treatment of advanced leiomyosarcoma is challenging. First-line therapy for metastatic and/or unresectable leiomyosarcoma includes anthracycline or gemcitabine based regimens, which provide a median progression-free survival time of about 5 months and overall survival time between 14-16 months. Effective later-line therapies are limited. Molecular profiling has enhanced our knowledge of the pathophysiology driving leiomyosarcoma, providing potential targets for treatment. In this review, we explore recent advances in our understanding of leiomyosarcoma tumor biology and implications for novel therapeutics. We describe the development of clinical trials based on such findings and discuss available published results. To date, the most promising approaches for advanced leiomyosarcoma include targeting DNA damage repair pathways and aberrant metabolism associated with oncogenesis, as well as novel chemotherapy combinations. This review highlights the recent progress made in the treatment of advanced leiomyosarcoma. Ongoing progress is contingent upon further development of clinical trials based on molecular findings, with careful consideration for clinical trial design, strong academic collaborations, and prospective correlative analyses.
Design, synthesis and evaluation of a series of potential prodrugs of a Bruton’s tyrosine kinase (BTK) inhibitor
Authors: Xiao Zhou-Peng , Liao Min , Huang Xue-Juan , Wang Yu-Tong , Lan Xiao-Cui , Wang Xue-Ying , Li Xi-Tao
Published: March 2023

BTK has become a particularly attractive therapeutic target in autoimmune diseases and B-cell malignancies, making BTK inhibitors a valuable and important therapeutic option. We present the design, synthesis, and evaluation of a series of prodrugs of a BTK inhibitor with an insoluble 2,5-diaminopyrimidine structure. Tails containing different solubilizing groups were added to the parent molecule via an ester linkage. Prodrug 5a showed good aqueous solubility and could be efficiently converted to the parent in a human plasma stability study. The rational prodrug design was supported by molecular studies and a dramatically reduced BTK kinase-inhibitory potential. Taken together, the chemical, biological, and molecular studies suggest that prodrug derivatization of the 2,5-diaminopyrimidine scaffold could be a potential strategy for advancing this series of BTK inhibitors into the therapeutic arena.
A hybrid neural architecture search for hyperspectral image classification
Authors: Wang Aili , Song Yingluo , Wu Haibin , Liu Chengyang , Iwahori Yuji
Published: March 2023

Convolution neural network (CNN)is widely used in hyperspectral image (HSI) classification. However, the network architecture of CNNs is usually designed manually, which requires careful fine-tuning. Recently, many technologies for neural architecture search (NAS) have been proposed to automatically design networks, further improving the accuracy of HSI classification to a new level. This paper proposes a circular kernel convolution-β-decay regulation NAS-confident learning rate (CK-βNAS-CLR) framework to automatically design the neural network structure for HSI classification. First, this paper constructs a hybrid search space with 12 kinds of operation, which considers the difference between enhanced circular kernel convolution and square kernel convolution in feature acquisition, so as to improve the sensitivity of the network to hyperspectral information features. Then, the β-decay regulation scheme is introduced to enhance the robustness of differential architecture search (DARTS) and reduce the discretization differences in architecture search. Finally, we combined the confidence learning rate strategy to alleviate the problem of performance collapse. The experimental results on public HSI datasets (Indian Pines, Pavia University) show that the proposed NAS method achieves impressive classification performance and effectively improves classification accuracy.
Cognitive fitness modulates gender differences in sleep and mental health among competitive athletes under chronic stress
Authors: Mascaro Luis , Drummond Sean P. A. , Leota Josh , Boardman Johanna M. , Hoffman Daniel , Rajaratnam Shantha M. W. , Aidman Eugene , Facer-Childs Elise R.
Published: March 2023

Objectives: Mental fitness is increasingly considered a key component of an athlete’s competitive arsenal. Active domains of mental fitness include cognitive fitness, sleep, and mental health; and these domains can differ between men and women athletes. Our study investigated the associations of cognitive fitness and gender to sleep and mental health, and the interaction between cognitive fitness and gender on sleep and mental health, in competitive athletes during the COVID-19 pandemic.

Methods: 82 athletes competing at levels from regional/state to international (49% women, M-age = 23.3 years) completed measures of self-control, intolerance of uncertainty, and impulsivity (together representing constructs of cognitive fitness), items about sleep (total sleep time, sleep latency, and mid-sleep time on free days) and a measure of mental health (depression, anxiety, and stress).

Results: Women athletes reported lower self-control, higher intolerance of uncertainty, and higher positive urgency impulsivity compared with men athletes. Women reported sleeping later, but this gender difference disappeared after controlling for cognitive fitness. Women athletes—after controlling for cognitive fitness—reported higher depression, anxiety, and stress. Across genders, higher self-control was associated with lower depression, and lower intolerance of uncertainty was associated with lower anxiety. Higher sensation seeking was associated with lower depression and stress, and higher premeditation was associated with greater total sleep time and anxiety. Higher perseverance was associated with higher depression for men—but not women—athletes.

Conclusion: Women athletes in our sample reported poorer cognitive fitness and mental health compared to men athletes. Most cognitive fitness factors protected competitive athletes under chronic stress, but some exposed them to poorer mental health. Future work should examine the sources of gender differences. Our findings suggest a need to develop tailored interventions aimed at improving athlete wellbeing, with a particular focus on women athletes.
Molecular and histological validation of modified in ovulo nucellus culture based high-competency direct somatic embryogenesis and amplitude true-to-the-type plantlet recovery in Kinnow mandarin
Authors: Murugan Theivanai , Awasthi Om Prakash , Singh Sanjay Kumar , Chawla Gautam , Solanke Amolkumar U. , Kumar Sunil , Jha Girish Kumar
Published: March 2023

Kinnow (Citrus nobilis Lour. × Citrus deliciosa Ten.) needs to be genetically improved for traits such as seedlessness using biotechnological tools. Indirect somatic embryogenesis (ISE) protocols have been reported for citrus improvement. However, its use is restricted due to frequent occurrences of somaclonal variation and low recovery of plantlets. Direct somatic embryogenesis (DSE) using nucellus culture has played a significant role in apomictic fruit crops. However, its application in citrus is limited due to the injury caused to tissues during isolation. Optimization of the explant developmental stage, explant preparation method, and modification in the in vitro culture techniques can play a vital role in overcoming the limitation. The present investigation deals with a modified in ovulo nucellus culture technique after the concurrent exclusion of preexisting embryos. The ovule developmental events were examined in immature fruits at different stages of fruit growth (stages I–VII). The ovules of stage III fruits (>21–25 mm in diameter) were found appropriate for in ovulo nucellus culture. Optimized ovule size induced somatic embryos at the micropylar cut end on induction medium containing Driver and Kuniyuki Walnut (DKW) basal medium with kinetin (KIN) 5.0 mg L-1 and malt extract (ME) 1,000 mg L-1. Simultaneously, the same medium supported the maturation of somatic embryos. The matured embryos from the above medium gave robust germination with bipolar conversion on Murashige and Tucker (MT) medium + gibberellic acid (GA3) 2.0 mg L-1 + ά-naphthaleneacetic acid (NAA) 0.5 mg L-1 + spermidine 100 mg L-1 + coconut water (CW) 10% (v/v). The bipolar germinated seedlings established well upon preconditioning in a plant bio regulator (PBR)-free liquid medium under the light. Consequently, a cent percent survival of emblings was achieved on a potting medium containing cocopeat:vermiculite:perlite (2:1:1). Histological studies confirmed the single nucellus cell origin of somatic embryos by undergoing normal developmental events. Eight polymorphic Inter Simple Sequence Repeats (ISSR) markers confirmed the genetic stability of acclimatized emblings. Since the protocol can induce rapid single-cell origin of genetically stable in vitro regenerants in high frequency, it has potential for the induction of solid mutants, besides crop improvement, mass multiplication, gene editing, and virus elimination in Kinnow mandarin.
Navigation and closed-loop control of magnetic microrobot in plant vein mimic environment
Authors: Huan Zhijie , Wang Jiamin , Zhu Lan , Zhong Zhixiong , Ma Weicheng , Chen Zhoufan
Published: March 2023

In recent years, research on the manipulation and control of microrobot has gradually matured. In order to improve the intelligence of microrobots, navigation study also becomes an important research topic. In practice, microrobots could be disturbed by the flowing liquid when it moves in a microfluidic environment. As a result, the actual trajectory of microrobots will deviate from the intended one. In this paper, firstly, different algorithms for the navigation of microrobots in a simulated plant leaf vein environment are investigated. According to the simulation results, RRT*-Connect is then selected as the path planning algorithm with a relatively better performance. Based on the pre-planned trajectory, a fuzzy PID controller is further designed for precise trajectory tracking, which can effectively eliminate the random disturbance caused by micro-fluid flow during the motion and make it quickly recover to a stable movement state.
Strategies of prosociality: Comparing Nordic and Slavonic altruism toward Ukrainian refugees
Authors: Larsen Mads , Witoszek Nina
Published: March 2023

Nordic high-trust societies are underpinned by prosociality, a term denoting cooperation and working for the good of others. State-funded voluntarism provides opportunities for altruism that appears to contribute to the Nordics’ exceptional level of well-being. Altruists are rewarded by a warm, lasting affect that enhances personal well-being, thus motivating further prosociality. Humanity’s evolutionary past coded into us a desire to strengthen our community by helping those in need—a biocultural drive that is corrupted when authoritarian regimes enforce unselfish behavior on disempowered populations. Such coercive altruism has a line of adverse long-term consequences for communal functionality and individual flourishing. Our study examines how sociocultural context influences people’s prosocial strategies, and how sharing insights and practices from democratic and authoritarian traditions can lead to new, revitalized forms of altruism. Our in-depth interviews (n = 32) of Nordic and Slavonic helpers of Ukrainian refugees in Norway (1) illuminate the impact of culture and memory on altruistic practices, (2) define points of tension between systemic and anti-systemic modes of prosociality, and (3) identify cross-cultural interactions that generate trust, well-being, and social innovation. The post-communist experience of the Slavonic informants motivated anti-systemic altruism, which highlights spontaneity, improvisation, and occasional rule breaking. Norwegian systemic altruism is based on trust, efficacy, and rule-following. Our evolutionary approach to cultural psychology substantiates how important it is for development and immigration policies to align our knowledge of human nature with insights into the workings of cultural legacies. A better understanding of the biocultural mainsprings of altruism could be of crucial importance in our era of reemerging authoritarianism and increasing migration.
The effect of social norms on vegetarian choices is moderated by intentions to follow a vegetarian diet in the future: Evidence from a laboratory and field study
Authors: Hammami Alya , Garcia Armelle , Darcel Nicolas , Higgs Suzanne , Davidenko Olga
Published: March 2023

Social norms could be a tool in dietary transition toward more sustainable diets, but the results of social norms interventions aimed at encouraging the selection of plant-based foods to date have been inconsistent. One reason for this might be because there are important moderating factors that have yet to be investigated. Here we examine social modeling of vegetarian food choices and test whether modeling is dependent upon individual intentions to follow a vegetarian diet in the future in two different settings. In a laboratory study of 37 women, participants with low intentions to become a vegetarian consumed fewer plant-based foods in the presence of a vegetarian confederate, compared to eating alone. In an observational study of 1,037 patrons of a workplace restaurant, participants with a higher score of on vegetarian intentions had a greater likelihood of taking a vegetarian main course or starter, and a vegetarian social norm was associated with a greater likelihood of a vegetarian choice for the main course but not for the starter. These data suggest that participants with low intentions to follow a vegetarian diet may exhibit reactance against an explicit vegetarian norm in an unfamiliar context (as in Study 1) but that general norm following regardless of dietary intentions be more likely when it is conveyed implicitly in a familiar context (as in Study 2).
From experience to expectation: The reverse effect of power on purchasing impulsiveness
Authors: Wang Yanzhi , Yao Tang , Qiu Qi
Published: March 2023

Introduction

Previous literatures have mainly explored the impact of the experience of power on impulsive buying, but have ignored the impacts of the expectations of power. The purpose of this research is to delineates a two-facet portrait of power in the role of affecting purchase impulsiveness by proposing a theoretical extension from the experience of power to the expectations of power.

Methods

Four laboratory experiments were developed that used ANOVA to verify the hypothesis. A moderated mediation path model was established including the experience of power, product attribute, the expectations of power, deservingness, and purchasing impulsiveness as observed variables.

Results

The results revealed that powerless consumers are more likely to impulsively buy hedonic products; while powerful consumers prefer to impulsively buy utilitarian products. However, when focusing on the expectations of power, powerless consumers feel a lower perception of deservingness, which reduces their impulse to buy hedonic products. In contrast, when powerful consumers imagine how powerful people should behave in consumption, they will experience a higher sense of deservingness and increase purchasing impulsiveness for hedonic products. The underlying mechanism is that deservingness plays a mediation role in the three-way interaction impacts of the experience of power, product attribute, and the expectations of power on purchasing impulsiveness.

Conclusion

The current research formulates a new theoretical perspective on the relationship between power and purchasing impulsiveness. An experience-expectation model of power is presented that proposes consumers’ purchasing impulsiveness can be affected both by the experience of power and the expectations of power.
A model of teachers’ growth mindset, teaching enjoyment, work engagement, and teacher grit among EFL teachers
Authors: Liu Li , Fathi Jalil , Allahveysi Seyyed Pedram , Kamran Kimia
Published: March 2023

Because of the importance of positive emotions in second language (L2) acquisition, researchers have undertaken studies to investigate L2 learners’ emotions. Nevertheless, L2 teachers’ emotions still require more scholarly attention. Against this backdrop, we sought to test a model of teachers’ growth mindset, teaching enjoyment, work engagement, and teacher grit among English as a foreign language (EFL) teachers. To this end, 486 Chinese EFL teachers volunteered to partake in an online survey and completed the questionnaires of the four constructs in question. Confirmatory factor analysis was performed to ensure the construct validity of the used scales. Then structural equation modeling (SEM) was used to test the hypothesized model. SEM results indicated that teaching enjoyment, teacher grit, and growth mindset directly predicted EFL teachers’ work engagement. In addition, teaching enjoyment affected work engagement indirectly via the mediation of teacher grit. Likewise, teacher grit mediated the effect of growth mindset on teachers’ work engagement. Finally, the implications of these findings are discussed.
English linguistic neo-imperialism in the era of globalization: A conceptual viewpoint
Authors: Zeng Jie , Ponce Ariel Robert , Li Yuxin
Published: March 2023

As Phillipson warned, “[l]inguistic imperialism [is] alive and kicking” and has become even more subtle in an era when English has become the global lingua franca. With this, this conceptual paper aims to propose features of linguistic neo-imperialism by describing how English has continuously spread and retained its power in various domains particularly in periphery countries, whether ex-colonies or non-colonies. Broadly, we highlight these features from the aspects of communication, business, academia, and education. The features of English linguistic neo-imperialism are interrelated and interactive in these fields, reinforcing the current dominant position of English. We then proceed with drawing implications for the local languages, particularly in their preservation and use alongside English and other dominant lingua francas.
Longitudinal progression of choroid plexus enlargement is associated with female sex, cognitive decline and ApoE E4 homozygote status
Authors: Novakova Martinkova Julie , Ferretti Maria Teresa , Ferrari Alberto , Lerch Ondrej , Matuskova Veronika , Secnik Juraj , Hort Jakub ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: March 2023

Introduction

Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease. In this pilot study, we aimed to elucidate the association between longitudinal changes in CP volume, sex and cognitive impairment.

Methods

We assessed longitudinal changes in CP volume in a cohort of n = 613 subjects across n = 2,334 datapoints from ADNI 2 and ADNI-GO, belonging to cognitively unimpaired (CN), stable mild cognitive impairment (MCI), clinically diagnosed Alzheimer’s disease dementia (AD) or convertor (to either AD or MCI) subgroups. CP volume was automatically segmented and used as a response variable in linear mixed effect models with random intercept clustered by patient identity. Temporal effects of select variables were assessed by interactions and subgroup analyses.

Results

We found an overall significant increase of CP volume in time (14.92 mm3 per year, 95% confidence interval, CI (11.05, 18.77), p < 0.001). Sex-disaggregated results showed an annual rate of increase 9.48 mm3 in males [95% CI (4.08, 14.87), p < 0.001], and 20.43 mm3 in females [95% CI (14.91, 25.93), p < 0.001], indicating more than double the rate of increase in females, which appeared independent of other temporal variables. The only diagnostic group with a significant CP increase as compared to CN was the convertors group, with an increase of 24.88 mm3/year [95% CI (14, 35.82), p < 0.001]. ApoE exhibited a significant temporal effect, with the E4 homozygote group’s CP increasing at more than triple the rate of non-carrier or heterozygote groups [40.72, 95% CI (25.97, 55.46), p < 0.001 vs. 12.52, 95% CI (8.02, 17.02), p < 0.001 for ApoE E4 homozygotes and E4 non-carriers, respectively], and may have modified the diagnostic group relationship.

Conclusion

Our results contribute to potential mechanisms for sex differences in cognitive impairment with a novel finding of twice the annual choroid plexus enlargement in females and provide putative support for CP-related mechanisms of cognitive deterioration and its relationship to ApoE E4.
Animal studies reveal that the ghrelin pathway regulates alcohol-mediated responses
Authors: Jerlhag Elisabet
Published: March 2023

Alcohol use disorder (AUD) is often described as repeated phases of binge drinking, compulsive alcohol-taking, craving for alcohol during withdrawal, and drinking with an aim to a reduce the negative consequences. Although multifaceted, alcohol-induced reward is one aspect influencing the former three of these. The neurobiological mechanisms regulating AUD processes are complex and one of these systems is the gut-brain peptide ghrelin. The vast physiological properties of ghrelin are mediated via growth hormone secretagogue receptor (GHSR, ghrelin receptor). Ghrelin is well known for its ability to control feeding, hunger, and metabolism. Moreover, ghrelin signaling appears central for alcohol-mediated responses; findings reviewed herein. In male rodents GHSR antagonism reduces alcohol consumption, prevents relapse drinking, and attenuates the motivation to consume alcohol. On the other hand, ghrelin increases the consumption of alcohol. This ghrelin-alcohol interaction is also verified to some extent in humans with high alcohol consumption. In addition, either pharmacological or genetic suppression of GHSR decreases several alcohol-related effects (behavioral or neurochemical). Indeed, this suppression blocks the alcohol-induced hyperlocomotion and dopamine release in nucleus accumbens as well as ablates the alcohol reward in the conditioned place preference model. Although not fully elucidated, this interaction appears to involve areas central for reward, such as the ventral tegmental area (VTA) and brain nodes targeted by VTA projections. As reviewed briefly, the ghrelin pathway does not only modulate alcohol-mediated effects, it regulates reward-related behaviors induced by addictive drugs. Although personality traits like impulsivity and risk-taking behaviors are common in patients with AUD, the role of the ghrelin pathway thereof is unknown and remains to be studied. In summary, the ghrelin pathway regulates addiction processes like AUD and therefore the possibility that GHSR antagonism reduces alcohol or drug-taking should be explored in randomized clinical trials.
Implementation of a peer support worker in a forensic psychiatric hospital in Germany—Views of patients
Authors: Walde Peggy , Hadala Julia , Peipe Verena , Völlm Birgit Angela
Published: March 2023

Introduction

Peer Support has become common in psychiatric practice in the past decade. In this article we present findings from the implementation of peer support service into a forensic mental health hospital for offenders with substance use disorders from a patient's perspective.

Methods

We conducted focus groups and interviews with patients of the clinic to explore their experiences, acceptance and perceived effect of the peer support service. Data collection was conducted in two different points in time, three months and twelve months after the introduction of the of some peer support intervention. In the first time point two focus groups involving 10 patients and three semi-structured individual interviews were conducted. The second time point included one focus group with five patients and five semi-structured individual interviews. All focus groups and individual interviews were audio recorded and transcribed verbatim. Data analysis was conducted using thematic analysis.

Results

Five themes emerged, (1) attitudes toward the concept of peer support work and the peer support worker himself; (2) Activities and conversation topics; (3) experiences and effects; (4) Peer support in contrast to other professions; and (5) ideas and wishes for future peer support in the clinic. In general, patients agreed on the high value of peer support work.

Discussion

Findings revealed a broad acceptance of the peer support intervention by most patients, but also some reservations. They saw the peer support worker as someone who is part of the professional team, and has a unique knowledge coming from personal experience. This knowledge often facilitated conversations about several topics related to patients experiences with substance use and their recovery journey.
A hidden pandemic? An umbrella review of global evidence on mental health in the time of COVID-19
Authors: Bower Marlee , Smout Scarlett , Donohoe-Bales Amarina , O’Dean Siobhan , Teesson Lily , Boyle Julia , Lim Denise , Nguyen Andre , Calear Alison L. , Batterham Philip J. , Gournay Kevin , Teesson Maree
Published: March 2023

Background

The mental health impacts of the COVID-19 pandemic remain a public health concern. High quality synthesis of extensive global literature is needed to quantify this impact and identify factors associated with adverse outcomes.

Methods

We conducted a rigorous umbrella review with meta-review and present (a) pooled prevalence of probable depression, anxiety, stress, psychological distress, and post-traumatic stress, (b) standardised mean difference in probable depression and anxiety pre-versus-during the pandemic period, and (c) comprehensive narrative synthesis of factors associated with poorer outcomes. Databases searched included Scopus, Embase, PsycINFO, and MEDLINE dated to March 2022. Eligibility criteria included systematic reviews and/or meta-analyses, published post-November 2019, reporting data in English on mental health outcomes during the COVID-19 pandemic.

Findings

Three hundred and thirty-eight systematic reviews were included, 158 of which incorporated meta-analyses. Meta-review prevalence of anxiety symptoms ranged from 24.4% (95%CI: 18–31%, I2: 99.98%) for general populations to 41.1% (95%CI: 23–61%, I2: 99.65%) in vulnerable populations. Prevalence of depressive symptoms ranged from 22.9% (95%CI: 17–30%, I2: 99.99%) for general populations to 32.5% (95%CI: 17–52%, I2: 99.35) in vulnerable populations. Prevalence of stress, psychological distress and PTSD/PTSS symptoms were 39.1% (95%CI: 34–44%; I2: 99.91%), 44.2% (95%CI: 32–58%; I2: 99.95%), and 18.8% (95%CI: 15–23%; I2: 99.87%), respectively. Meta-review comparing pre-COVID-19 to during COVID-19 prevalence of probable depression and probable anxiety revealed standard mean differences of 0.20 (95%CI = 0.07–0.33) and 0.29 (95%CI = 0.12–0.45), respectively.

Conclusion

This is the first meta-review to synthesise the longitudinal mental health impacts of the pandemic. Findings show that probable depression and anxiety were significantly higher than pre-COVID-19, and provide some evidence that that adolescents, pregnant and postpartum people, and those hospitalised with COVID-19 experienced heightened adverse mental health. Policymakers can modify future pandemic responses accordingly to mitigate the impact of such measures on public mental health.
Cybervictimization and non-suicidal self-injury among Chinese adolescents: The effect of depression and school connectedness
Authors: Liu Sui , Wu Wanchun , Zou Hongyu , Chen Yanrong , Xu Liling , Zhang Wei , Yu Chenfu , Zhen Shuangju
Published: March 2023

Cybervictimization has been shown in many studies to be a risk factor for adolescent non-suicidal self-injurious behavior (NSSI). In this study we tested the roles of depression and school connectedness in this association. The Integrative Model of NSSI, Emotion Regulation and Interpersonal Relationship Model of NSSI, and Integrative Model of Social Media and Suicide provided the conceptual framework for the study. A sample of 1106 adolescents (Mage = 13.17; SD = 0.69; 51.78% girls) completed anonymous questionnaires in their classrooms. The results of structural equation modeling showed that the positive association between cybervictimization and adolescent NSSI was mediated by depression. Moreover, this indirect link was stronger for adolescents with low vs. high school connectedness. The results have implications for intervention programs aimed at reducing NSSI among adolescents.
Supply-demand balance and spatial distribution optimization of primary care facilities in highland cities from a resilience perspective: A study of Lhasa, China
Authors: Yu Yang , Zhou Rui , Qian Liyuan , Yang Xian , Dong Liuyang , Zhang Guangyuan
Published: March 2023

Introduction

The development of urban resilience, which is fundamentally a balance between the supply capacity of primary care resources and the demand from urban residents, includes an appropriate architecture of primary care facilities. Resilient city construction in highland areas is hampered by the physical environment and transportation constraints and frequently encounters issues like poor accessibility and unequal distribution of primary care facilities.

Methods

To optimize the supply and demand of primary care resources in highland cities and effectively improve the resilience of urban public health, this paper assesses the distribution of primary care facilities within the built-up area of Lhasa (China) through a spatial network analysis method based on GIS, combined with population distribution data, and employs a location-allocation model to optimize the distribution.

Results

Firstly, the overall supply of primary care exceeds the overall demand, but the facilities' service area can only accommodate 59% of the residences. Secondly, there is a clear spatial variation in the accessibility of primary care facilities, and the time cost of healthcare is too high in some residences. Thirdly, the supply-demand relationship of primary care facilities is unbalanced, with both over-saturated and over-deficient areas.

Discussion

After distribution optimization, the coverage and accessibility of primary care facilities have increased significantly, and the spatial imbalance of supply and demand has been alleviated. This paper proposes a research method to evaluate and optimize the spatial distribution of primary care facilities from multiple perspectives based on the resilience theory. The results of the study and visualization analysis methods can be used as an invaluable reference for planning the distribution of urban healthcare facilities and urban resilience construction in highland areas and other underdeveloped areas.
Effectiveness of horticultural therapy in aged people with depression: A systematic review and meta-analysis
Authors: Xu Meijing , Lu Shan , Liu Jianjiao , Xu Feng
Published: March 2023

Background

Depression, an increasing global crisis, has affected many people's daily life, especially for older adults. Horticultural therapy has been widely used in non-pharmacological treatment for patients with depression, with a body of studies demonstrating its therapeutic effects. However, a lack of systematic reviews and meta-analyses makes it difficult to get a holistic picture of this research field.

Objectives

We aimed to evaluate the reliability of the previous studies and the effectiveness of horticultural therapy (including the intervention of environmental settings, activities, and duration) on older adults with depression.

Methods

This systematic review was conducted under the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) guidelines. We searched relevant studies in multiple databases, and the original search was finished on 25 September 2022. We included studies using randomized controlled trials (RCTs) or quasi-experimental designs.

Results

We yielded a total of 7,366 studies and finally included 13 which involved 698 aged people with depression. Results from meta-analysis indicated significant effects of horticultural therapy on reducing depressive symptoms for the older adults. Besides, we found different outcomes among various horticultural interventions (such as environmental setting, activities, and duration). Depression reduction was more effective in care-providing settings than in community settings; participatory activities were more effective in reducing depression than observational activities; intervention of 4–8 weeks might represent the optimal course of treatment compared to interventions more than 8 weeks in duration.

Conclusion

We came up with a comprehensive set of recommendations based on the meta-analysis: aged people in care-providing settings with depression could get the most benefit from horticultural therapy by participating in participatory activities for 4–8 weeks.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022363134, identifier CRD42022363134.
Association between serum manganese and serum klotho in a 40–80-year-old American population from NHANES 2011–2016
Authors: Guan Guoyu , Cai Jiasheng , Zheng Songbai , Xiang Yanzhen , Xia Shijin , Zhang Yixuan , Shi Jiaqiang , Wang Jun
Published: March 2023

Objectives: Manganese is one of the essential trace elements that are required by the human body. Klotho protein is a classic anti-aging marker. The association between the levels of serum manganese and serum klotho in individuals between the ages of 40–80 in the United States remains unclear.

Methods: Data for this cross-sectional study was obtained from the National Health and Nutrition Examination Survey (NHANES 2011–2016) in the United States. We performed multiple linear regression analyses to investigate the association between the levels of serum manganese and serum klotho. Furthermore, we performed a fitted smoothing curve according to a restricted cubic spline (RCS). Stratification and subgroup analyses were performed for further verification of the results.

Results: Weighted multivariate linear regression analysis showed that serum manganese levels were independently and positively associated with serum klotho levels (β = 6.30, 95% confidence interval: 3.30–9.40). Kruskal–Wallis test showed that participants with higher manganese quartiles had higher serum klotho levels (Q1: 808.54 ± 256.39 pg/mL; Q2: 854.56 ± 266.13 pg/mL; Q3: 865.13 ± 300.60 pg/mL; and Q4: 871.72 ± 338.85 pg/mL, p < 0.001). The RCS curve indicated that the association between the levels of serum manganese and serum klotho was non-linear. Furthermore, a significantly positive association was found between serum manganese and serum klotho levels in the majority of subgroups.

Conclusion: A non-linear and positive association was found between the levels of serum manganese and serum klotho in individuals aged 40–80 in the United States according to the NHANES (2011–2016).
Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish
Authors: Smirnova Lena , Caffo Brian S. , Gracias David H. , Huang Qi , Morales Pantoja Itzy E. , Tang Bohao , Zack Donald J. , Berlinicke Cynthia A. , Boyd J. Lomax , Harris Timothy D. , Johnson Erik C. , Kagan Brett J. , Kahn Jeffrey , Muotri Alysson R. , Paulhamus Barton L. , Schwamborn Jens C. , Plotkin Jesse , Szalay Alexander S. , Vogelstein Joshua T. , Worley Paul F. , Hartung Thomas
Published: March 2023

Recent advances in human stem cell-derived brain organoids promise to replicate critical molecular and cellular aspects of learning and memory and possibly aspects of cognition in vitro. Coining the term “organoid intelligence” (OI) to encompass these developments, we present a collaborative program to implement the vision of a multidisciplinary field of OI. This aims to establish OI as a form of genuine biological computing that harnesses brain organoids using scientific and bioengineering advances in an ethically responsible manner. Standardized, 3D, myelinated brain organoids can now be produced with high cell density and enriched levels of glial cells and gene expression critical for learning. Integrated microfluidic perfusion systems can support scalable and durable culturing, and spatiotemporal chemical signaling. Novel 3D microelectrode arrays permit high-resolution spatiotemporal electrophysiological signaling and recording to explore the capacity of brain organoids to recapitulate the molecular mechanisms of learning and memory formation and, ultimately, their computational potential. Technologies that could enable novel biocomputing models via stimulus-response training and organoid-computer interfaces are in development. We envisage complex, networked interfaces whereby brain organoids are connected with real-world sensors and output devices, and ultimately with each other and with sensory organ organoids (e.g. retinal organoids), and are trained using biofeedback, big-data warehousing, and machine learning methods. In parallel, we emphasize an embedded ethics approach to analyze the ethical aspects raised by OI research in an iterative, collaborative manner involving all relevant stakeholders. The many possible applications of this research urge the strategic development of OI as a scientific discipline. We anticipate OI-based biocomputing systems to allow faster decision-making, continuous learning during tasks, and greater energy and data efficiency. Furthermore, the development of “intelligence-in-a-dish” could help elucidate the pathophysiology of devastating developmental and degenerative diseases (such as dementia), potentially aiding the identification of novel therapeutic approaches to address major global unmet needs.