bluuebunny/crossref_metadata_2025 huggingface dataset:
Systemic inflammation and metabolic syndrome components in threshold/subthreshold posttraumatic stress disorder and food addiction in a Polish community sample
Authors: Stojek Monika Magdalena , Łukowska Marta , Różycka Jagoda , Sokołowska Maryla , Zielińska Joanna , Nowacki Ari , Duszkiewicz Roksana , Psurek Anna , Michopoulos Vasiliki
Published: November 2024

Background: Posttraumatic stress disorder (PTSD) is associated with metabolic syndrome and various addictive behaviors. Food addiction (FA) is associated with obesity, and individuals with PTSD have higher rates of FA than those without. It is unclear whether addictive-like eating patterns contribute to the metabolic dysfunction in PTSD. Objective: We examined the relative contributions of PTSD, FA, and gender – as well as their interactive effects – to the systemic inflammation (CRP) and metabolic syndrome components (MetS: waist circumference, glucose, triglycerides, HDL cholesterol, insulin) in a general population of the Upper Silesia region in Poland. Method: N=187 participants (52.7% women) completed Yale Food Addiction Scale 2.0 (FA symptoms count), Clinician Administered PTSD Scale for DSM-5 (CAPS-5) semi-structured interview (PTSD or other trauma and stressor related disorder (OTSR) diagnosis presence), anthropometric assessment, and phlebotomy in a fasted state. Results: A series of hierarchical linear regressions indicated that greater number of FA symptoms had a significant effect on greater waist circumference, while PTSD/OTSR diagnosis had a significant effect on greater inflammation and higher insulin levels. Gender did not moderate these relationships. Conclusions: It appears that dysregulated eating patterns contribute to greater abdominal obesity, but do not contribute to metabolic dysfunction. PTSD/OTSR, but not FA, contributes to greater inflammatory response and greater insulin levels. The average metabolic indices were within normal limits reflecting a non-clinical nature of the sample. Future longitudinal studies should examine whether detection of and intervention for PTSD/OTSR symptoms may be a strategy for preventing progression of metabolic dysfunction.
Introduction: Timely Matters
Authors: Walton Jeremy F. , Eisenlohr Patrick , Newell Sasha
Published: November 2024

In this introduction to our edited volume, we discuss the theoretical forebears that inform our guiding concept of “material temporalities” with an eye to the collections impact on contemporary debates in anthropology and beyond. To begin, we situate “material temporalities” in relation to the temporal and material turns that have reoriented anthropology in recent years. In particular, we emphasize the dual property of material temporalities in offering affordances to and constituting forms of recalcitrance for human actors. Following this, we discuss the two orders of time, human and non-human, that intersect in the assemblages of material temporalities, as well as a number of key inspirations for our theorization of material temporalities—Walter Benjamin’s notion of messianic time and Michel Foucault’s concept of heterochrony, specifically. This discussion of human and nonhuman times supports our critique of “clock time” and its errant aspiration to an objective material basis for temporality. Following this, we offer an overview of both recent and longstanding anthropological engagements with temporality and historicity, as well as a summary of recent media studies perspectives on time and materiality, which mount a more radical intervention and critique than most anthropological arguments. We then review anthropological debates over affect and materiality in order to argue for the centrality of temporality and historicity to affective matters. Finally, we summarize the three volume’s major thematic clusters—virtuality and latency; material extensions of phenomenological time; and, material futures—with reference to the specific contributions.
Examining Language and Communication in Autistic People with Complex Support Needs – A Scoping Review of Procedural and Measurement Issues and Practice
Authors: Donald Sarah , Edwards Nalini , Remington Anna , Henry Lucy , Gaigg Sebastian
Published: November 2024

AbstractBackground: Autistic people with complex support needs have historically been under-represented in research. Developing an understanding of, and suitable interventions for the language and communication needs of this group has been identified as a priority area for research by the autistic community (Autistica, 2016) but progress to date has been slow. This scoping review seeks to provide an overview of current research practices to identify potential barriers hindering progress and to inform recommendations for future research based on current best practices.Methods: We searched eleven electronic databases for published and unpublished literature that focused on aspects of language and communication and that reported separately on autistic people with complex support needs, as defined by a broad set of search terms. Searches and extraction were performed by one researcher, with a second researcher verifying 20% of the sample. Quantitative (e.g., frequencies of use of measurement tools) and qualitative (i.e., content analysis of adaptations made) syntheses were conducted.Results: Searches returned 4064 unique articles, of which 888 were deemed eligible for screening on full text, resulting in the final inclusion of 190 published papers. Findings indicate a lack of consistency in the use of terminology and considerable variation in how terminology is defined and operationalised. Over half of all studies did not report on consent procedures, with only five individual papers reporting on strategies used for assessing ongoing assent. Approximately half of all assessment tools identified were only used once. Tools relying on proxy reporting or observation were most common. Study-specific approaches were the most common approach taken to measuring aspects of language and communication change. Researchers frequently sought to adapt the participant to the needs of the measurement tool rather than vice versa.Conclusions: The current literature is plagued by inconsistencies in defining key concepts and terminology and in the measurement approaches and tools used to operationalise key variables of interest. Findings are discussed in relation to wider research practice and we offer nine recommendations for future research.Keywords: Autism, Minimally Verbal, Complex Needs, Language and Communication, Research methodology, Measurement, Ethics, Consent, Assent.
Dynamic Ransomware Detection with Adaptive Encryption Pattern Recognition Techniques
Authors: Totham David , Andersson Victor , Thompson Harrison , Whitmore Jonathan , Beckett Lawrence
Published: November 2024

The increasing sophistication of cyber-attacks continues to challenge conventional detection systems, with ransomware posing one of the most persistent threats to data security in both public and private sectors. Addressing the limitations of static and heuristic-based detection approaches, Adaptive Encryption Pattern Recognition (AEPR) introduces a dynamic, pattern-based framework that focuses specifically on encryption anomalies unique to ransomware. AEPR’s architecture integrates adaptive thresholding with machine learning to enhance the detection of high-frequency and high-entropy encryption activities, allowing for precise identification of ransomware variants even as they evolve. Leveraging a modular design, AEPR achieves high detection accuracy across diverse system environments and ransomware types, while maintaining computational efficiency suitable for both resource-limited and high-throughput settings. Experimental evaluations demonstrate AEPR’s superior classification performance, with low false positive and false negative rates that reduce unnecessary alerts and increase operational reliability. Through its targeted, resource-efficient approach, AEPR provides a scalable and resilient solution that addresses critical gaps in contemporary ransomware detection, offering a significant advancement for cybersecurity infrastructure.
Dorsomedial and ventromedial prefrontal cortex lesions differentially impact social influence and temporal impulsivity
Authors: Su Zhilin , Garvert Mona , Zhang Lei , Vogel Todd A , Cutler Jo , Husain Masud , Manohar Sanjay G , Lockwood Patricia
Published: November 2024

The medial prefrontal cortex (mPFC) has long been associated with economic and social decision-making in neuroimaging studies. Several debates question whether different ventromedial PFC (vmPFC) and dorsomedial PFC (dmPFC) regions have specific functions or whether there is a gradient supporting social and non-social cognition. Here, we tested an unusually large sample of rare participants with focal damage to mPFC (N = 33), individuals with lesions elsewhere (N = 17), and healthy controls (N = 71) (total N = 121). Participants completed a temporal discounting task to estimate their baseline discounting preferences before learning the preferences of two other people, one who was more temporally impulsive and one more patient. We used Bayesian computational models to estimate baseline discounting and susceptibility to social influence after learning others’ economic preferences. mPFC damage increased susceptibility to impulsive social influence compared to healthy controls and increased overall susceptibility to social influence compared to those with lesions elsewhere. Importantly, voxel-based lesion-symptom mapping (VLSM) of computational parameters showed that this heightened susceptibility to social influence was attributed specifically to damage to the dorsomedial prefrontal cortex (dmPFC, area 9). In contrast, lesions in the vmPFC (areas 13 and 25) and ventral striatum were associated with a preference for seeking more immediate rewards. We show that the dmPFC is causally implicated in susceptibility to social influence, with distinct ventral portions of mPFC involved in temporal discounting.
PEMANFAATAN MEDIA PEMBELAJARAN PADA PEMBUATAN FILM SEJARAH PERJUANGAN RATU ZALEHA SANG SRIKANDI BANJAR
Authors: Sholehah Hafizatun
Published: November 2024

Media pembelajaran merupakan gabungan dari dua kata yang saling berhubungan, media berarti alat bantu guru di sekolah dan pembelajaran berarti proses berinteraksinya guru dan peserta didik serta seluruh komponen belajar. Media pembelajaran dapat digunakan untuk berbagai macam mata pelajaran, salah satunya ada sejarah. Sehingga media pembelajarannya disebut sebagai media pembelajaran sejarah. Pada pembuatan film sejarah perjuangan Ratu Zaleha sang srikandi Banjar termasuk pada media pembelajaran sejarah berbasis elektronik. Jenis media ini menggunakan sarana elektronik baik dalam proses desainnya maupun dalam pemanfaatannya, yaitu berupa film. Ratu Zaleha adalah salah satu kaum wanita yang sangat tangguh dari keturunan Pangeran Antasari. Adanya Ratu Zaleha menyatakan bahwa tidak hanya seorang laki-laki saja yang bisa berjuang dalam menyerang penjajahan tapi para kaum perempuan pun juga ikut berjuang dalam melawan penjajahan.
Analisis Sentimen Review Aplikasi PeduliLindungi Menggunakan Seleksi Fitur Information Gain Berbasis SVM
Authors: Abror Dzulchan
Published: November 2024

Aplikasi PeduliLindungi merupakan salah satu langkah pemerintah Indonesia dalam menekan penyebaran virus Covid 19. Aplikasi ini terdapat pada google play store yang didalamnya disediakan fasilitas rating dan ulasan bagi pengguna aplikasi. Fasilitas ini dapat kita manfaatkan untuk menggali beberapa informasi salah satunya dengan mengelompokkan ulasan menurut polaritas yang ada yaitu positif atau negative. Sehingga dapat diperoleh informasi pandangan masyarakat terhadap sebuah produk atau aplikasi tersebut, bidang penelitian ini dinamakan analisis sentimen. Dalam membangun sebuah model analisis sentimen terdapat suatu permasalahan dimensi fitur yang sangat tinggi, karena didalam teks mining memiliki ribuan fitur. Fitur tersebut kebanyakan irelevan dan tidak berpengaruh terhadap kelas, akibatnya tingkat akurasi model menurun. Solusinya diperlukan suatu metode yang dapat menyeleksi fitur-fitur teks tersebut. Pada penelitian kali ini diajukan metode sentimen analisis terhadap review aplikasi PeduliLindungi dengan metode SVM (Support Vector Machine)  berbasis seleksi fitur information gain. Dataset diambil dari ulasan pengguna berjumlah 300 ulasan dengan metode penelitian membandingkan 2 model, yang pertama SVM tanpa seleksi fitur dengan hasil akurasi sebesar 74,33% dan model kedua SVM menggunakan seleksi fitur information gain dengan hasil akurasi sebesar 84%. Hal ini membuktikan bahwa dengan metode seleksi fitur dapat meningkatkan akurasi. Kata kunci : Pedulilindungi, Analisis Sentimen, Seleksi Fitur, Information Gain, SVM
Implementasi Laporan Laba Rugi UMKM Berbasis Website pada Aplikasi KasirTa
Authors: Siswanto Rahmat , Ramadhan Abid , Ansar Ansar , Qamariah Ade
Published: November 2024

Transaksi yang dilakukan oleh usaha mikro kecil menengah (UMKM) sebagian besar masih dicatat manual menggunakan kertas atau buku catatan khusus. Pencatatan transaksi secaara manual ini dapat menyebabkan berbagai persoalan mulai dari kesalahan pencatatan, kehilangan bukti transaksi hingga pada kesalahan menghitung jumlah laba atau rugi UMKM. Kesalahan dalam pencatatan transaksi akan berimbas pada ketidakakuratan laporan laba rugi UMKM. Oleh karena itu, penulis membuat sebuah platform aplikasi bernama KasirTa yang dapat digunakan oleh UMKM bukan hanya sekedar mencatat transaksi penjualan namun dapat menampilkan laporan laba rugi usaha yang dikelola. Metode yang digunakan dalam pengembangan Aplikasi KasirTa dibangun menggunakan metode pengembangan aplikasi prototipe dan laporan keuangan yang diimplementasikan adalah laporan laba rugi. Pengembangan aplikasi menggunakan metode prototipe ini merupakan solusi terbaik dalam merancang aplikasi secara capat sesuai dengan kebutuhan inti dari pengguna. Implementasi laporan laba rugi pada aplikasi KasirTa juga menjadi solusi untuk menampilkan laporan laba-rugi secara akurat yang berproses dari pencatatan transaksi penjualan dan transaksi pengeluaran. Adanya sistem ini mengubah proses pencatatan secara manual menjadi terkommputerisasi, transparan dan lebih akurat.               Kata kunci: point of sales, laporan laba rugi, aplikasi web, digitalisasi UMKM, KasirTa
The contribution of environmental interpretation in nature protection
Authors: Stojanović Vladimir , Demonja Damir , Tišma Sanja , Mijatov Ladičorbić Maja , Dragin Aleksandra
Published: November 2024

The interpretation of natural values and the management of visitors in protected areas are related in multiple ways and are an important link in nature protection activities. This paper examines the basic elements of the interpretation and management of visitors in the selected protected areas of the Republic of Croatia. Protected areas are one of the main attributes of the tourist image of Croatia, with significant economic effects in the generated traffic of visitors. However, this can also contribute to the degradation of natural values or, on the other hand, can help protect nature. Due to such challenges, it is necessary to better understand the importance of visitor centres, tourist tours and the way in which codes of ethics are applied in protected areas. In this paper the representation of environmental interpretation techniques and tools in seven protected areas in Croatia were investigated, using information that was obtained mainly through survey research. The basic results indicate that Croatia has made progress in the previous period in the field of interpretation of natural and cultural values in its protected areas. Such progress is not only related to regions where tourism has a mass character and where visits are significant, but has also been made in remote continental parts of the country. Such an approach in the development of protected areas also indicates that these areas are not only massive tourist destinations, but also places for a more complex understanding of the concept of nature protection and sustainable development associated with the use of its potentials.
FEATURES OF BUSINESS AND PR ACTIVITIES IN WARTIME
Authors:   Odessa National Maritime University, Natalia Natalia , Karetnikova Irina ,   Odessa National Maritime University
Published: November 2024

Ukraine has faced unprecedented social and humanitarian losses in recent years and suffered serious destructive processes. The hostilities that were unleashed by the Russian Federation had a negative impact on the Ukrainian economy, which necessitated a revision of business practices and communication with partners. Both entrepreneurship and PR management during the war are completely different, because it is very difficult to build far-reaching plans, and decisions have to be made quickly. The business management should act adapting to external environment in such a situation: interact transparently with the team and customers, and clearly understand where the company is moving. The value of PR managers increases during this period, because the viability of enterprises depends on their work.The article presents the results of the analysis of the business environment after the start of hostilities.The problems faced by entrepreneurs are analysed, and it is proposed to use the theory and practice of PR management to create, maintain, and develop a business in emergency conditions. The main measures of support for entrepreneurs by the state are considered. The paper discusses the features of entrepreneurial and PR activities in wartime. The authors suggested options for adapting PR methods for building communications with both external customers and employees of companies.A set of methods of theoretical research was used when writing the work: abstraction, analogy, classification, generalization, synthesis, analysis of literature.Keywords:entrepreneurial activity, business, PR management, martial law, economic activity.
Envelhecimento e políticas públicas na América Latina e no Brasil
Authors: Maria do Rosário de Fátima e Silva  , Maria de Jesus Assunção e Silva
Published: November 2024

O artigo tem por objetivo refletir sobre o processo de envelhecimento no Brasil e na América latina, identificando os desafios e as perspectivas que cercam este processo no contexto de uma realidade profundamente desigual, social e economicamente, agravada pela pandemia da Covid 19. Neste sentido buscar-se-á analisar como as políticas públicas de proteção social tem enfrentado esses desafios com vistas a garantia de direitos aos cidadãos e as cidadãs idosas. A análise percorrerá a agenda pública estatal no Brasil e nos demais países do continente latino-americano, apanhando a legislação que conforma os direitos do segmento social idoso, tendo como referência as duas primeiras décadas do século XXI. Tomar-se-á como base de análise além da agenda pública, a legislação social voltada para as necessidades da população idosa, e os compromissos definidos pelas Conferências Intergovenamentais sobre Envelhecimento na América latina e Caribe realizadas pela CEPAL.
KADIN İSTİHDAMININ İŞ VE AİLE YAŞAM UYUMUNA ETKİLERİ
Authors: Akgül İsmail
Published: November 2024

18. y. y. da başlayan sanayi devrimi siyasal, ekonomik, psikolojik ve sosyal boyutları beraber; birey, aile ve toplumsal yaşamı derinden etkilemiş ve tek boyutlu birey tipolojisini ve kapitalist yaşam biçimini ortaya çıkarmıştır. 21. Yüz yıla gelindiğinde ise kültürel kapitalizmin küreselleşmesiyle birlikte tüketim toplumuyla birlikte anılan yeni yaşam kültürü, modern zamanların bir fenomeni olarak karşımıza çıkmıştır.

Sanayileşme ile birlikte kırsal alanlardan kentlere yoğun göçler yaşanmış olup, kentlerde gecekondu tipi yapılaşmalar ve alt sosyo-ekonomik sınıf olarak nitelenebilecek yeni sosyal yapılar ortaya çıkmıştır. Yaşanan yoğun göç ve nüfus dinamikleri ile birlikte kentleşme hız kazanmış ve kadın da toplum ve çalışma hayatında aktif olarak yerini almıştır.

Bu süreçte geniş aile yapısı değişime uğrayarak, çekirdek aileye dönüşmüştür. Anne-baba ve çocuk üçgeninde oluşan bu yeni küçük ayrışmış aile modelinde babanın yanı sıra anne de aktif olarak çalışma yaşamında yerini alınca; çocuk bakım ve gözetiminin yanı sıra çocuğun okul ve eğitim hayatı toplumsal bir olgu ve yeni bir sorun alanı olarak modern yaşamda yerini almıştır.

Öte yandan dünyadaki sınırlı ekonomik kaynaklar karşısında aşırı nüfus artışı, kent yaşamının bir parçası olan modern bireyin ihtiyaçlarındaki artış ile birlikte yenilerinin de eklenmesi, tüketim toplumu kültürüne bağlı yeni alışkanlıkların ve yaşam tarzlarının ortaya çıkışı, teknolojik gelişmelerin birey ve toplum üzerindeki etkileri, gelir adaletsizliği, toplumu derinden etkileyen toplumsal olaylar ve doğal afetler gibi pek çok faktör kent yaşamındaki gelir adaletsizliğini ve ekonomik yetersizliği derinleştirmiş ve birey ve aile üzerindeki negatif etkisini artırmıştır.

Bu yaşam dinamikleri karşısında gerek kök ailenin yetişkin üyeleri ve gerek çekirdek ailenin ebeveynleri yaşamı idame ettirmek ve ailenin ekonomik ihtiyaçlarını karşılamak için psiko-sosyal ve duygusal gereksinimlerini önemli ölçüde ötelemek ya da ihmal etmek durumunda kalmışlardır.

Bu da iş ve aile yaşam uyumunda kronikleşen yeni ve modern bir sosyal olguyu gündeme getirmiştir.

1. GİRİŞ:
Inovação digital em comunicação social estudo de caso numa rede hospitalar
Authors: Weber Luciano , Dandolini Gertrudes Aparecida , Souza João Artur
Published: November 2024

As novas tecnologias permitem o advento incremental de inovação digital nas organizações. Em busca de compreender esse processo, esta pesquisa faz um comparativo entre o estudo de caso do setor de comunicação social em hospitais administrados pela Ebserh e a literatura. O objetivo geral desdobra-se em dois caminhos específicos para desvelar os processos de mudança nos hospitais dessa rede, um estrutural e outro tecnológico, cuja simbiose preparou o campo para a inovação em fase de implementação. Utilizou-se o método qualitativo para obter as informações do estudo de caso e capturar na literatura o que a ciência fala sobre o entrelaçamento de inovação digital, comunicação social e gerenciamento hospitalar em rede. Após as comparações, conclui-se que os resultados coadunam com a hipótese de que o valor agregado à organização ocorre mesmo durante a fase de implementação de uma inovação.
A model of the decision support system for managing the process of growing vegetables in a greenhouse
Authors: Lendiel M. , Lendiel T.
Published: November 2024

The developed of automatic control systems provide constant monitoring of technological indicators in greenhouses, as well as reporting on the current state in real time and conducting analysis based on available data.

Having this data in the system, the manufacturer can analyze all key indicators, their changes and impact over time and make appropriate decisions for their enterprise. However, the created systems expand over time, and accordingly the information in them also expands, so it is necessary to effectively analyze previously entered data. In this case, there is a need to create a system that will analyze indicators based on accumulated data. It is proposed to carry out analysis using OLAP and Data Mining technologies.

The purpose of the research is to implement a data warehouse of a decision support system using Data Mining technology to increase the efficiency of growing vegetables in closed soil structures.

In the process of developing an automated control system, a storage model of these decision support systems was developed. In the work, the structure of the dynamic database was developed using the time series algorithm. At the same time, data input, storage and analysis modules were created. The use of Data Mining technology for the analysis of large volumes of information was proposed. The obtained results of the system can be used in the process of forming management decisions for managing technological processes in the greenhouse economy. This will allow you to direct the management strategy of individual business processes in such a way as to increase the yield in greenhouses and, accordingly, the profitability of the farm as a whole.
Energy-efficient chamber dryer with combined heating heat transfer
Authors: Petrova Zh. , Vyshnevskyi V.
Published: November 2024

Chamber dryers are widely used in the processing of vegetables and fruits in Ukraine, the USA, China, France, etc. They are intended for drying lumpy (artificial) products (bread, chopped vegetables and fruits, etc.). A chamber dryer is a connection of one or more dryer cabinets in location mode. In a 2-zone chamber dryer, it is possible to dry large volumes of raw materials, which consumes less energy compared to the power that the entire drying cabinet has when it is operated separately. But high energy costs for the process of drying materials with high prices for the second encourage to solve the task of increasing energy efficiency when creating new chamber dryers using electronic heaters of the coolant.

The Institute of Technical Thermal Physics of the National Academy of Sciences of Ukraine suggests using steam heat generators in the operation of a multi-zone tunnel dryer, which, in comparison with organic fuel heat generators, make it possible to save heat consumption by 1.7-2.3 times compared to existing analogues. Energy consumption of heat in the tunnel dryer is 3800 kJ/kg of evaporated moisture.

To reduce energy costs, solar tunnel dryers with an increase in the heat exchange surface due to the maximum separation of pallets with raw materials at different angles have become widespread. Due to the influence of solar energy, the temperature of the drying agent can reach 70 °С.

The main direction of the development of drying plant materials is the combination of existing technologies with renewable energy sources, in particular the use of solar energy, heat pumps, as well as microwave, infrared and sublimation drying.

Combined drying technology is the combination of two or more different drying processes that can provide a synergistic effect, resulting in reduced energy requirements and reduced drying time while maintaining most of the quality characteristics, such as taste, nutrients, color, aroma, texture, etc.

Different methods of combined drying are considered, such as: solar-infrared, convective-infrared, infrared-microwave, convective-microwave and multifunctional, which combines microwave-sublimation drying under vacuum. The comparison of the combined methods showed a significant decrease in the duration of drying and a reduction in energy consumption, which can be used in the design of tunnel energy-efficient dryers.
Theoretical investigation on Friedel−Crafts reaction followed by rear-rangement/aromatization or ring-opening delivering benzoheterocycle and polycyclic alcohol, biaryl carboxylic acid
Authors: Lu Nan
Published: November 2024

Our DFT calculations provide the first theoretical investigation on CF3SO3H-promoted [1,5]Friedel−Crafts of 2-aryoxy-1,3-indandione and base-facilitated [1,6]Friedel−Crafts of 1,3-dicarbonyl. An intramolecular [1,5]Friedel−Crafts addition took place by activating carbonyl through H bridge with CF3SO3H. The resulting tertiary alcohol underwent dehydration producing reactive carbocation, which instigated a cascade of carbox-yl group formation, ring-opening via C−C bond dissociation and C=C bond formation realizing aromatization. The product 3-aryl-2-benzo was yielded with recovered CF3SO3H. The electron-rich phenoxy group was deprotonated by HO- forming water. The initial nucleophilic addition to spatial-adjacent carbonyl afforded dieneone. It isomerized to the first product polycyclic alcohol. Then carboxylation occurred via hydroxyl shift followed by ring-opening aromatization to the second product biaryl carboxylic acid. The positive solvation effect is suggested by decreased absolute and activation energies in solution compared with in gas. These results are supported by Multiwfn analysis on FMO composition of specific TSs, and MBO value of vital bonding, breaking.
Brainstem hemorrhage associated with venous hypertensive myelopathy without dural arteriovenous fistula: illustrative case
Authors: Hanai Sho , Yanaka Kiyoyuki , Akimoto Ken , Marushima Aiki , Nakamura Kazuhiro , Takahashi Nobuyuki , Matsumaru Yuji , Ishikawa Eiichi
Published: November 2024

BACKGROUND

Venous hypertensive myelopathy (VHM), formerly known as “Foix-Alajouanine syndrome,” is a spinal cord dysfunction caused by impaired perfusion of the spinal cord. Most cases are attributed to spinal dural arteriovenous fistulas (dAVFs), but there are scattered reports of VHM without concomitant dAVF. Furthermore, no cases of VHM associated with intracranial hemorrhage exist.

OBSERVATIONS

A 68-year-old man with a history of hypertension presented with a sudden headache, proximal paresis of the left upper extremity, impaired pain and temperature sensation in the right upper extremity, dysphagia, and dysarthria. Computed tomography scans showed intraparenchymal hemorrhage in the left medulla oblongata and a linear, continuous high-density area extending from the medulla oblongata to the cervical spinal cord. Magnetic resonance images showed cervical spondylosis at the C5–6 and C6–7 levels, with high signal intensity changes from the medulla oblongata to the lower cervical cord on T2-weighted images. Cerebral angiography showed no abnormal vessels. Conservative treatment gradually improved symptoms and the high signal intensity areas.

LESSONS

This case highlights intracranial hemorrhage occurring from extracranial causes and the possibility of VHM due to cervical spondylosis. When hemorrhagic lesions of the craniovertebral junction or spinal parenchymal lesions are encountered, the underlying pathology should be investigated thoroughly and systematically.

https://thejns.org/doi/10.3171/CASE24441
Intracranial pleomorphic liposarcoma misclassified as a pleomorphic xanthoastrocytoma by a DNA methylation classifier: illustrative case
Authors: Go Kohichi , Makino Yasuhide , Takeuchi Yasuhide , Minamiguchi Sachiko , Takada Shigeki , Sano Noritaka , Tanji Masahiro , Mineharu Yohei , Hojo Masato , Haga Hironori , Arakawa Yoshiki
Published: November 2024

BACKGROUND

Recently, it has been shown that DNA methylation arrays and German Cancer Research Center (Deutsches Krebsforschungszentrum) methylation classifiers are useful aids in brain tumor diagnosis for cases in which histopathological diagnosis is difficult. However, not enough is known about diagnostic aids for intracranial liposarcoma (LPS).

OBSERVATIONS

An 18-year-old woman with a history of natural killer/T-cell lymphoma, which had been treated with a bone marrow transplant and total body irradiation at age 11 years, presented with diplopia. Magnetic resonance imaging revealed a brain tumor in the posterior left temporal lobe, which was removed by craniotomy. The tumor was initially diagnosed as pleomorphic xanthoastrocytoma through histopathological and DNA methylation examination. She also had a soft tissue tumor in her left thigh, which was removed. It contained spindle cells with oval nuclei and highly pleomorphic cells and was diagnosed as radiation-induced LPS. Histopathological re-examination of the brain tumor led to a final diagnosis of pleomorphic LPS.

LESSONS

In this report, the authors describe the case of a patient with an intracranial pleomorphic LPS that was initially classified as a pleomorphic xanthoastrocytoma by a DNA methylation classifier. Although DNA methylation classifiers are useful as diagnostic aids in cases in which definitive pathology is difficult to determine, there is a risk of misdiagnosis in some types of tumors.

https://thejns.org/doi/10.3171/CASE24465
Rare posterior mediastinal hemangiomas invading the spinal cord through the intervertebral foramen and causing acute symptoms: illustrative case
Authors: Xu Chongxi , Yang Xiang , Jiang Yongliang , Wang Yuwen , Wang Jiaxi , Xu Bin , Xu Jianguo , Ma Junpeng
Published: November 2024

BACKGROUND

Hemangioma is a rare vascular tumor characterized by endothelial cell proliferation that primarily occurs in soft tissues. While most cases in the paraspinal posterior mediastinum are clinically indolent, they can also exhibit aggressive growth, leading to severe clinical outcomes and necessitating urgent treatment.

OBSERVATIONS

A 61-year-old right-handed female presented with reduced lower-extremity mobility that had begun 4 days earlier. An examination revealed that both lower limbs had grade 4 muscle strength. Computed tomography and magnetic resonance imaging revealed a right T1–3 paravertebral dumbbell-shaped soft tissue mass invading the spinal canal, destroying the T2 vertebra, and compressing the spinal cord and nerve roots. Elective surgery was planned, but a rapid muscle strength decline prompted emergency surgery. Postoperative muscle strength improved to grade 4, and at the 3-month follow-up, muscle strength had fully recovered.

LESSONS

Postoperative pathological examination revealed that the mediastinal dumbbell-shaped lesion was a hemangioma. While most hemangiomas progress slowly, acute symptoms of spinal cord compression are exceedingly rare. This case demonstrates the aggressive behavior of hemangioma, which invaded through the intervertebral foramen and compressed the spinal cord, resulting in acute symptoms. This case also shows that surgical removal of the tumor and restoration of spine stability via a posterior approach has proven beneficial.

https://thejns.org/doi/10.3171/CASE24485
Vertebral endarterectomy combined with endovascular treatment for patients with vertebral artery stenosis and vertebral aneurysm: illustrative case
Authors: Yang Fan , Li Shilin , Chen Yuanbing , Xie Jiayi , Liu Yi , Peng Fei , Chen Xuge , Xia Jiaxiang , Xu Boya , Wang Zhifei , Jiang Jiaode , Liu Aihua
Published: November 2024

BACKGROUND

Vertebral artery stenosis (VAS) and vertebral aneurysms are serious conditions that can be life-threatening and have a poor prognosis. The co-occurrence of VAS and a vertebral aneurysm is less common and more difficult to treat.

OBSERVATIONS

The authors report the case of a patient who presented with a rare occurrence of VAS combined with a vertebral aneurysm. The optimal treatment for both VAS and the vertebral aneurysm is intravascular therapy. Since the guidewire was unable to establish an effective channel, vertebral endarterectomy was performed in combination with endovascular treatment.

LESSONS

A combination of vertebral endarterectomy and endovascular treatment can effectively manage the co-occurrence of VAS and a vertebral aneurysm.

https://thejns.org/doi/10.3171/CASE2475
Два ветхозаветных чуда воскрешения: сравнительный анализ 3 Цар. 17:17–24 и 4 Цар. 4:18–37
Authors: Кашкин Алексей Сергеевич Кашкин Алексей Сергеевич
Published: November 2024

В Великую Субботу читаются две паремии, каждая из которых повествует о воскрешении пророком отрока: пророк Илия воскрешает сына вдовы из Сарепты Сидонской и пророк Елисей воскрешает сына женщины из Сонама. Интересно сравнить два эти эпизода, выявить их сходства и различия. Парадоксально, но различий гораздо больше, чем сходств. Среди значимых различий отметим следующие: большее время между смертью ребенка и воскрешением, вера сонамитянки в возможность воскрешения сына, Елисею пришлось приложить большие усилия для оживления отрока.Анализ различий позволяет говорить о превосходстве чуда Елисея над аналогичным чудом Илии. В конце статьи приводится сравнение ветхозаветных чудес воскрешения с новозаветными.

On the Great Saturday we read two readings, each of which tells of a prophet raising a young boy: the prophet Elijah raises the son of a widow from Zarephath of Sidon and the prophet Elisha raises the son of a woman from Shunem. It is interesting to compare these two episodes, to identify their similarities and differences. Paradoxically, there are far more differences than similarities. Among the significant differences are the following: the longer time between the child’s death and resurrection, the Shunammite’s belief in the possibility of her son’s resurrection, Elisha had to make great efforts to revive the boy. The analysis of differences allows us to speak about the superiority of Elisha’s miracle over the similar miracle of Elijah. The article concludes with a comparison of Old Testament miracles of resurrection with New Testament miracles.
Тропологический анализ кн. прор. Иеремии в святоотеческой мысли
Authors: Николай Павлов
Published: November 2024

В статье рассматриваются основные святоотеческие положения тропологического толкования кн. прор. Иеремии, в наиболее развернутом виде представленные в творениях свт. Игнатия (Брянчанинова), прп. аввы Дорофея и прп. Максима Исповедника. Указанные положения сопоставлены друг с другом и приведены в единую тропологическую картину Иерусалима времен вавилонского пленения. Согласно сделанному выводу, кн. прор. Иеремии в полной мере сохраняет свою актуальность для назидания и духовной поддержки христианина в скорбях, сопряженных с неизбежными в земной жизни претыканиями и падениями.

The article examines the main patristic provisions of the tropological interpretation of the book of the prophet Jeremiah, presented in the most de-tailed form in the works of St. Ignatius (Bryanchaninov), St. Abba Dorotheus and St. Maximus the Confessor. These provisions are compared with each other and brought into a single tropological picture of Jerusalem during the Babylonian captivity. According to the conclusion, the book of the prophet Jeremiah fully retains its relevance for the edification and spiritual support of a Christian in sorrows associated with the inevitable stumbles and falls in earthly life.
Поминовение усопших как один из аспектов богословия Артемия, игумена Троице-Сергиева монастыря
Authors: Глеб Алексеевич Осипов
Published: November 2024

Артемий, богослов середины XVI века — видный представитель движения нестяжателей. Непродолжительное время в 1551 году он был игуменом Троице-Сергиева монастыря, впоследствии на Московском Соборе 1553–1554 гг. был лишён сана, осуждён как еретик и заточён в Соловецком монастыре. После 1554 года Артемий, сбежав из заключения, оказывается в Великом княжестве Литовском, где принимает активное участие в полемике православных с протестантами. На означенном Соборе в отношении Артемия были выдвинуты различные обвинения, и главное из них — причастность Артемия к ереси Матфея Семёновича Башкина. Среди иных обвинений значилось также и отрицание Артемием пользы от поминовения усопших. Если другие обвинения, как, например, неосуждение новгородско-московских еретиков, легкомысленное отношение к обрядности, равно как и причастность к ереси М.С. Башкина, были Артемием отвергнуты, то своё отношение к поминальной практике обвиняемый игумен отчасти признал. Задача данной статьи заключается в анализе отношения Артемия к поминовению усопших. Мы покажем, что данный аспект богословия бывшего игумена напрямую связан с полемикой о монастырском землевладении, имевшей место в XVI веке в Московской Руси.

Artemius, the theologian of the middle of the 16th century, is a prominent figure of the non-possessors movement. For a short time in 1551, he was hegumen of the Holy Trinity-St. Sergius Monastery. Later at the Moscow Council of 1553–1554, he was defrocked, condemned as a heretic and imprisoned in the Solovetsky Monastery. After 1554, Artemius, having escaped from prison, finds himself in the Grand Duchy of Lithuania, where he takes an active part in the polemic between the Orthodox and Protestants. At the Council mentioned above, various accusations were made against Artemy, and the main one was Artemius' involvement in the heresy of Matthew Semyonovich Bashkin. Among other accusations, Artemius was condemned in denial of the value of commemorating the dead. Whereas other accusations, such as the non-condemnation of the Novgorod-Moscow heretics, a frivolous attitude to rituals, as well as involvement in the heresy of M.S. Bashkin, were rejected by Artemius, the accused hegumen partially acknowledged his attitude to the church commemoraion.The aim of this article is to analyze Artemius’ attitude to the church commemoration of the dead. We will show that this aspect of the former hegumen's theology is directly related to the controversy about monasterial land ownership that took place in the 16th century in Muscovite Russia.
Богословие иконы и образа на Западе сегодня
Authors: Василий Петрович Ващаев
Published: November 2024

Данная статья посвящена рассмотрению западного восприятия богословия иконы и образа в настоящее время. Актуальность подобной тематики объясняется тем, что в конце XX— начале XXI-го века формируются современные теории изображения, пересматривающие отношения между образом и реальностью. Однако, наряду с этим продолжает существовать и развиваться направление, в котором священные изображения не просто сохраняют функции, усвоенные богословием Тридентского собора, но и становятся источником вдохновения за пределами современного искусства и живописи.

This article deals with the Western perception of the theology of the icon and the image today. As sacred images in this context do not simply retain the functions assimilated to them by the Council of Trent. But also become an important point of reference, a source of inspiration beyond modern art and painting. When, because of the concept of 'simulacra' and the proliferation of digital images in the late 20th and early 21st century, modern theories of the image are formed, reconsidering the relationship between the image and 'reality'.
New Spheromorphic Problematics Gaparella from the Lower Cambrian of Western Mongolia
Authors: Luzhnaya E. A.
Published: November 2024

From the lower part of the Tommotian Stage of the Lower Cambrian of Western Mongolia, ridge Hevte-Tsakhir-Nuruu described a new problematical sphaeromorhical microfossils Gaparella elenae sp. nov.; a new combination of generic and specific names Gaparella kuanchuanpuensis (Qian, 1977). has been proposed. Despite its very peculiar morphology, the genus Gaparella Missarzhevsky in Missarzhevsky et Mambetov, 1981 is more often mentioned in the list of synonyms of the genus Archaeooides Qian, 1977. The taphonomic variability of Mongolian Gaparella is shown and the morphology is reconstructed: these were hollow spheres, with a perforated double thin wall; between the holes, which were located chaotically on small elevations, a system of canals was developed; the wall may have been organic with an admixture of mineral components. Based on their lifestyle, these fossils were probably planktonic filter feeders. Their level of organization appears to have been consistent with Porifera; most likely these were juvenile forms.
First Specimens of the Cornutan Stylophora Phyllocystis (Echinodermata) in the Ordovician (Volkhov Regional Stage, Dapingian and Darrivilian) of Baltica and Special Aspects of Stylophora Axial Symmetry
Authors: Rozhnov S. V. , Anekeeva G. A.
Published: November 2024

Described two new species of cornutan stylophora of the genus Phyllocystis from the Volkhov Regional Stage (Middle Ordovician, Dapingian) of Baltica. This points to the biogeographic connection between Afro-European part of Gondwana and Baltica since the very beginning of the Middle Ordovician. Both species were confined to cold-water, shallow conditions with low water mobility. Analysis of the axial symmetry of the stylophora and the location of the hydropore indicates the absence of torsion in their ontogeny and the location of the ambulacral system to the right of their anteroposterior axis. To explain this structure, two alternative hypotheses have been proposed: 1) inversion inversion in the development of right and left coelomes; 2) inverted state of stylophora compared to other invertebrates, what makes them similar to the chordates in terms of the position of the dorsal and ventral sides.
Alterations in store-operated calcium entry in neurodegenerative pathologies: history, facts, perspectives
Authors: Vigont V. A. , Kaznacheyeva E. V.
Published: November 2024

Neurodegenerative disorders, along with cardiovascular and oncological pathologies, are one of the most actual issues facing modern medicine. Therefore, the study of the molecular mechanisms of their pathogenesis and the search for new drug targets is highly demanded. Neuronal calcium signalling has attracted close attention, as altered calcium homeostasis has been demonstrated in the pathogenesis of various neurodegenerative diseases. In this review, we focus on one of the most ubiquitous and important pathways for calcium uptake: store-operated calcium entry. Here we describe studies demonstrating disturbances in store-operated calcium entry in various neurodegenerative pathologies, including Alzheimer’s, Parkinson’s and Huntington’s diseases. Also, we analyse the molecular determinants underlying these disturbances and propose ways for pharmacological correction of altered calcium signaling. The information summarized in the review will allow us to consider store-operated calcium channels as promising targets for the drug development in order to treat neurodegenerative pathologies and outline further promising directions for the investigation.
Membrane-dependent reactions of blood coagulation: classical view and state-of-the-art concepts
Authors: Kovalenko T. A. , Panteleev M. A.
Published: November 2024

The complex mechanism called hemostasis evolved in living organisms to prevent blood loss when a blood vessel is damaged. In this process, two closely interconnected systems are distinguished: platelet-vascular and plasmatic hemostasis. Plasmatic hemostasis is a system of proteolytic reactions, in which blood plasma proteins called coagulation factors are involved. A key feature of this system is the localization of enzymatic reactions on the surface of phospholipid membranes, which increases their rate by up to 5 orders of magnitude. This review describes the basic mechanisms of coagulation factors binding to phospholipid membranes, pathways for complex assembly and activation reactions, and discusses the role of membranes in this process, their composition and sources. The binding of coagulation factors to procoagulant membranes leads not only to the acceleration of coagulation reactions, but also to their selective localization in restricted areas and protection from being washed away by the flow. The efficiency of coagulation reactions is regulated by the composition of the outer layer of the membrane, primarily through a special mechanism of mitochondria-dependent necrotic platelet death.
Lipid-mediated adaptation of proteins and peptides in cell membranes
Authors: Polyansky A. A. , Efremov R. G.
Published: November 2024

The paper overviews the results of computational studies of the molecular mechanisms underlying the adaptation of model cell membranes taking place during their interaction with proteins and peptides. We discuss changes in the structural and dynamic parameters of the water–lipid environment, the hydrophobic/hydrophilic organization of the lipid bilayer surface (the so-called “mosaicity”), etc. Taken together, these effects are called the “membrane response” (MR) and constitute the most important ability of the cell membranes to respond specifically and consistently to the incorporation of extraneous agents, primarily proteins and peptides, and their subsequent functioning. The results of the authors’ long-term research in the field of molecular modeling of MR processes with various spatial and temporal characteristics are described, from the effects of binding of individual lipid molecules to proteins to changes in the integral macroscopic parameters of membranes. The bulk of the results were obtained using the “dynamic molecular portrait” approach developed by the authors. The biological role of the observed phenomena and potential ways of rationally designing artificial membrane systems with specified MR characteristics are discussed. This, in turn, is important for targeted changes in the activity profile of proteins and peptides exerting action on biomembranes, not least as promising pharmacological agents.