bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Exercise and Physical Activity Levels on Childhood Cancer: An Umbrella Review
Authors: Rapti Christina , Dinas Petros C. , Chryssanthopoulos Costas , Mila Alexandra , Philippou Anastassios
Published: March 2023

Patients and survivors of childhood cancer experience adverse effects related to the disease and its treatment. These adverse effects are associated with both physiological and psychological health. Exercise helps manage the side effects and improve the health outcomes. The objective of this umbrella review is to search the current literature in the context of exercise and physical activity as complementary interventions on pediatric cancer and to provide comprehensive information about the derived health outcomes. A literature search was conducted on the Cochrane, PubMed, and Embase databases for systematic reviews published up to January 2023. Moreover, a hand search of reference lists was performed. We included participants under 19 years of age at diagnosis of any type of childhood cancer, without restriction on the type or phase of treatment, who participated in exercise interventions. The results showed a beneficial impact on fatigue, muscle strength, aerobic capacity, activity and participation levels, psychosocial health, cardiovascular/cardiorespiratory fitness, physical function, bone mineral density, and brain volume and structure, with limited and not serious adverse effects. These findings documented that exercise interventions had a positive effect on many physiological and psychological health outcomes in pediatric cancer patients and survivors.
Analgesic Efficacy of Acupuncture on Chronic Pelvic Pain: A Systemic Review and Meta-Analysis Study
Authors: Lin Kent Yu-Hsien , Chang Yi-Chuan , Lu Wen-Chi , Kotha Peddanna , Chen Yi-Hung , Tu Cheng-Hao
Published: March 2023

Chronic pelvic pain (CPP) is the pain occurred in the pelvic region longer than six months. The monotherapy of medicine may not adequate for the pain management of CPP and multidisciplinary approaches have been more recommended. The aim of this study is to evaluate the pain management efficacy of acupuncture compared with a control group on CPP. The articles of randomized controlled trial on CPP in PubMed and Embase databases were screened between January 2011 and September 2022 without language restriction to evaluate the treatment efficacy of acupuncture. The visual analogue scale/numerical rating scale (VAS/NRS) and total pain scores of National Institutes of Health—chronic prostatitis symptom index (NIH-CPSI) were served as outcome variables. Post-intervention mean scores were extracted and pooled for meta-analysis. Seventeen studies including 1455 patients were selected for meta-analysis. Both total pain scores of NIH-CPSI and VAS/NAS data revealed significant lower pain level in the acupuncture group than in the control group. Moreover, monotherapy with acupuncture revealed a significantly lower pain level than in the control group in both total pain scores of NIH-CPSI and VAS/NRS. These results indicated that acupuncture may have beneficial effects on pain management for CPP, even when administrated as a monotherapy.
Characterization of Domestic Violence among Patients Consulting a French Psychiatric Emergency Department
Authors: Leveque Laetitia , Papadodima Stavroula , Toutin Ryan , Fraigneau Mathieu , Baccino Eric , Martrille Laurent
Published: March 2023

The aim of the present study was to identify the prevalence of domestic violence among patients attending a French psychiatric emergency department and its association with psychiatric disorders. This retrospective study was performed, including all patients examined in the psychiatric emergency department of the Lapeyronie University Hospital of Montpellier (France) in the daytime from 1 July 2021 to 31 October 2021. A total of 152 patients were eligible during this study period. The prevalence of domestic violence was 38.2% (n = 58) overall. The percentage of female victims of domestic violence was higher than that of male victims (47.6% vs. 17.0%, p < 0.001). Among the 58 victims of domestic violence, 20.7% reported psychological abuse, 17.2% physical abuse, 3.4% sexual abuse, and 58.6% multiple forms of abuse. The risk of suicide attempt and anxiety disorder among the female patients was associated with domestic violence (p = 0.006, OR = 7.24, and p = 0.010, OR = 0.16). Our study showed that the psychiatric population should be identified as a population at risk for domestic violence, especially when the patient is female and suffers from anxiety disorders or if she has performed a previous suicide attempt.
A Comparative Electromyographic Analysis of Flying Squirrel and 3-Point Quadripod Exercise for Lumbar Multifidus Muscle Activations among Healthy Female Subjects
Authors: Gasibat Qais , Rani Babina , Čaušević Denis , Perveen Wajida , Alexe Cristina Ioana , Albina Alina Elena , Alexe Dan Iulian
Published: March 2023

Physical therapists employ several exercises to alleviate low back pain (LBP). Electromyography (EMG) examination of exercises can monitor muscle activation to help clinicians determine the exercise’s effect on stabilisation, endurance, or strength. This study evaluated surface EMG activity comparison for Flying Squirrel Exercise (FSE) and the novel 3-Point Quadripod Exercise (3-PQE) to find the most effective exercise for stimulating the lumbar multifidus (LM) muscle. The study recruited 64 healthy young females (19–24 years). Raw data were normalized and are expressed as the percentage of maximum voluntary isometric contraction (%MVIC). The test–retest reliability of the EMG recordings was estimated using intraclass correlation coefficient (ICC3,1). One-way ANOVA was used to statistically analyse and compare the EMG amplitudes during the two exercises. The ICCs for 3-PQE and FSE were 0.94 (SEM, 21.7% MVIC) and 0.87 (SEM, 19.05% MVIC), respectively. The 3-PQE (69 ± 26% MVIC) demonstrated significantly higher activity than did FSE (30 ± 18% MVIC) (F = 15.573, p = 0.001). Thus, 3-PQE might be a feasible strategy for the prevention and rehabilitation of LBP in females.
Cause of Death among Long-Term Cancer Survivors: The NANDE Study
Authors: Fujii Makoto , Morishima Toshitaka , Nagayasu Mayumi , Kudo Haruka , Ohno Yuko , Sobue Tomotaka , Miyashiro Isao
Published: March 2023

Survival information for Japanese patients with cancer is based only on survival status and the cause of death among these patients remains unclear. In this study, Osaka Cancer Registry data (1985–2014) and vital statistics data (1985–2016) were linked to create a database, permitting the extraction of data on the causes of death. In total, 522,566 subjects diagnosed with cancer between 1995 and 2011 were analyzed. Follow-up for vital status was conducted 5 and 10 years after cancer diagnosis. To evaluate the three causes of death (index cancer, non-index cancer, and non-cancer death), cause-specific hazard and cumulative incidence functions were estimated using a life table and Gray’s methods. The number of deaths owing to any of the causes in the observation period (median: 3.51 years, mean: 4.90 years) was 394,146. The 5- and 10-year cancer-specific survival rate was 48.56% and 39.92%, respectively. Immediately after cancer onset, the hazard of index cancer death was high. The proportion of non-index cancer deaths was high in patients with mouth and pharynx cancers. The hazard of index cancer death remained constant for breast and liver cancers. In prostate, breast, and laryngeal cancers with good prognosis, the hazard of non-index cancer and non-cancer death constantly increased.
Perceptions, Knowledge, and Experiences of Using Face Masks among Egyptian Healthcare Workers during the COVID-19 Pandemic: A Cross-Sectional Study
Authors: Elgendy Marwa O. , El-Gendy Ahmed O. , Elgendy Sara O. , Abdelaty Lamiaa N. , Abdelrahim Mohamed E. A. , Abdelrahman Mona A.
Published: March 2023

Using face masks appropriately is important for preventing the community spread of respiratory infections. A cross-sectional study was conducted to evaluate the knowledge level and experience of using face masks between healthcare teams to protect them and limit the spread of COVID-19 infection. A structured questionnaire was distributed to 228 healthcare members in July–December 2021. It was divided into two sections and consisted of 29 questions for a total possible score of 0 to 29. The first section was related to perceptions and knowledge about face masks (13 items); the second was related to the experience of using face masks (16 items). The average score of this questionnaire was 23.21/29 with respect to the knowledge about face masks and their proper use techniques. The healthcare team studied had satisfactory knowledge about face mask use techniques, and the study shed light on their unsatisfactory practices. Following instructions is very vital to protecting the person wearing the mask and preventing the spread of infection during health care by blocking droplets produced by speaking or coughing. Providing the healthcare teams with knowledge and experience about how to use face masks during the pandemic is critical to increase their awareness and practice in using face masks and prevent the infection from spreading.
Effectiveness of Drama-Based Intervention in Improving Mental Health and Well-Being: A Systematic Review and Meta-Analysis during the COVID-19 Pandemic and Post-Pandemic Period
Authors: Jiang Lulu , Alizadeh Farideh , Cui Wenjing
Published: March 2023

As a creative form of psychotherapy, drama appears to assist individuals in the COVID-19 pandemic and post-pandemic period in altering crisis conditions and challenging negative perspectives. Drama-based intervention is presented as an option for addressing mental health issues in clinical and general populations by utilising various multidisciplinary sources, such as psychodrama and role playing. In this study, a systematic review and meta-analysis were employed to assess the impact of drama on mental health and well-being during the COVID-19 pandemic and post-pandemic. Four electronic databases (PubMed, Cochrane, Web of Science, and ScienceDirect) were extensively searched from December 2019 to October 2022. Quality assessment and Risk of Bias tool of the Cochrane Collaboration were performed. Using a random effect model, standardised mean difference (SMD) values and 95% confidence intervals (CI) were calculated. In the final analysis, 25 studies involving 797 participants were included. The study revealed that drama-based interventions have the potential to improve mental health (e.g., trauma-related disorders) and well-being (e.g., psychological well-being), which could position drama as an adjunctive method of mental health care. This original review offered the newer, more comprehensive recommendations for drama-based intervention based on evidence.
Doctor Attributes That Patients Desire during Consultation: The Perspectives of Doctors and Patients in Primary Health Care in Botswana
Authors: Setlhare Vincent , Madiba Sphiwe
Published: March 2023

Doctor attributes contribute significantly to the quality of the doctor–patient relationship, consultation, patient satisfaction, and treatment outcomes. However, there is a paucity of research on this topic in many settings in developing countries, including Botswana, where accessibility and availability of care itself are a challenge. The study examined doctor attributes that patients in Botswana desire from the perspectives of doctors and patients in selected public clinics located in four health districts of Botswana. We used a qualitative design and conducted face-to-face interviews with 32 adult patients and 17 doctors selected through the purposive sampling technique. Interviews were audio-recorded and transcribed. Data analysis followed the six steps of qualitative thematic data analysis. We found both discordance and congruence between the doctors and patients on key attributes that patients desire in a doctor during consultation. Both agreed that effective communication and listening skills were key desirable doctor attributes that improve the doctor–patient relationship. Conducting the consultation in the language of the patients enhances effective communication. Doctors cited clinical expertise and competence as key desirable doctor attributes, whereas patients cited interpersonal and social attributes including kindness, empathy, and respect as key doctor attributes that increase trust in the doctor. However, patients expected the doctor to have clinical knowledge, which they perceived as essential to improve doctor–patient interaction and health outcomes. The findings highlight a need to enhance the interpersonal and communication skills of doctors to improve the quality of doctor–patient interactions. To optimise and enhance the consultation, continuing professional development should be adopted as a strategy to improve the communication and interpersonal skills of doctors.
Geophysical Investigation at the Santa Chiara Church in Nardò (Southern Italy)
Authors: Giorgi Lara De , Barbolla Dora Francesca , Ferrari Ivan , Giuri Francesco , Torre Chiara , Leucci Giovanni
Published: March 2023

The church of Santa Chiara with its adjacent convent, whose foundations date back to the 13th century, is a monastic complex in the city of Nardò in the province of Lecce. The current church was built ex novo between the 17th and 18th centuries under the direction of Bishop Orazio Fortunato. Currently, there is no information about the presence of crypts or burials in the church and in the adjacent area. For this reason, a campaign of geophysical investigations was undertaken using electromagnetic, electrical resistivity and ground-penetrating radar methods. Geophysical investigations were carried out both inside and in the courtyard of the church. The results showed the presence of a series of anomalies, whose interpretation suggests important structures of probable archaeological interest.
A Water Stress–Tolerant Pepper Rootstock Improves the Behavior of Pepper Plants under Deficit Irrigation through Root Biomass Distribution and Physiological Adaptation
Authors: Gisbert-Mullor Ramón , Martín-García Rodrigo , Bažon Zidarić Iva , Pascual-Seva Nuria , Pascual Bernardo , Padilla Yaiza Gara , Calatayud Ángeles , López-Galarza Salvador
Published: March 2023

The use of rootstocks tolerant to water stress in pepper crops is a complementary technique for saving irrigation water without affecting yields by means of particular rootstock physiological traits, which changes the scion’s perception stress. The present study aimed to analyze the morphological and physiological adaptation of the ‘Cuerno’ pepper cultivar grafted onto tolerant rootstock NIBER® subjected to capacitance sensor-based deficit irrigation. The stomatal conductance, relative water content and leaf water potential parameters were used to confirm the degree of crop stress. Leaf dry weight and root volume were higher in the grafted plants under the control irrigation and stress treatment conditions. Total fresh root biomass and root volume percentage of grafted plants under water stress were 24% and 33% higher, respectively, than the ungrafted plants. The grafted plants subjected to both water stress and control conditions had a higher marketable production than the ungrafted plants. The higher yields obtained using tolerant rootstocks were explained by the reduced blossom-end rot incidence.
Effect of Chitosan and Micro-Carbon-Based Phosphorus Fertilizer on Strawberry Growth and Productivity
Authors: Metwaly El-Saied E. , AL-Huqail Arwa Abdulkreem , Farouk Saad , Omar Genesia F.
Published: March 2023

High fertilization rates and pesticides are required for the intensive production of strawberries, which offer several therapeutic health benefits. Recently, chitosan (CHI), and phosphorus fertilizer based on Micro Carbon TechnologyTM (MCT-P) were applied to encourage strawberry sustainable production and enhance phosphorus-use efficiency. Field trials were conducted throughout 2020/2021 and 2021/2022, to evaluate the effectiveness of MCT–P and CHI in improving strawberry cv. Fortuna growth and yield as well as their quality. Foliar spraying of CHI and MCT-P considerably improved strawberry plant growth (i.e., plant height, secondary crown number per plant, leaf number and area per plant, and foliage fresh weight), photosynthetic pigment concentration (chlorophylla, chlorophyllb, and carotenoids), as well as its yield and quality (early fruit yield, total yield, average fruit weight, fruit firmness, fruit dry matter %, soluble solid content, total sugars (%), ascorbic acid, acidity, and anthocyanin). Compared to untreated plants, 1200 mgL−1 MCT-P and 1000 mg/L CHI supplementation was the most effective concentration for improving all studied characteristics. The interaction between CHI and MCT-P had a greater impact on all examined characteristics. It is recommended to spray strawberry cv. Fortuna with 1200 mg/L MCT-P plus 1000 mg/L CHI every two weeks, from 60 days after transplanting until two weeks before the end of harvesting season for the best fruit yield and quality.
Ovule Number and Flower Size in Pea (Pisum sativum L.): Variation, Heritability, and Correlation with Some Components of Productivity
Authors: Sinjushin Andrey , Ash Olga , Khartina Galina
Published: March 2023

The seed yield in pea (Pisum sativum L.) depends on numerous environmental and genotypic factors. The ongoing climate changes draw one’s attention to genetics and variation of underexplored reproductive traits. This study focuses on ovule number (ON) and flower size expressed as a length of flag petal (FL), in terms of their heritability, variability, and correlation with 1000 seed mass (TSM), seed number per pod, and seed/ovule ratio. A set of pea accessions was planted over several years in field conditions. Some of these accessions were also grown in a glasshouse. The chosen values were scored on living plants or while harvesting seeds. Nonparametric statistical methods were applied. Heritability of ON and FL was studied in five hybrid F1/F2 combinations. We found a relatively low (ca. 0.5) broad sense heritability of both ON and FL. Among other traits, TSM and ON reproduced best over the years. FL exhibited no reproducible correlations with other traits and cannot be used as a predictor of productivity. Water deficit and heat stress reduce seed yield in pea due to both seed abortion and development of fewer ovules. The differential and heritable ability to retain ON may become a basis for breeding pea cultivars adapted to changing climate.
Accumulative Effects of Multifrequency Microwave Exposure with 1.5 GHz and 2.8 GHz on the Structures and Functions of the Immune System
Authors: Yao Chuanfu , Dong Ji , Ren Ke , Sun Liu , Wang Hui , Zhang Jing , Wang Haoyu , Xu Xinping , Yao Binwei , Zhou Hongmei , Zhao Li , Peng Ruiyun
Published: March 2023

Microwave ablation can produce immune activation due to thermal effects. However, the nonthermal effects of microwaves on the immune system are still largely unexplored. In this study, we sequentially exposed rats to 1.5 GHz microwave for 6 min and 2.8 GHz microwave for 6 min at an average power density of 5, 10, and 30 mW/cm2. The structure of the thymus, spleen, and mesenteric lymph node were observed, and we showed that multifrequency microwave exposure caused tissue injuries, such as congestion and nuclear fragmentation in lymphocytes. Ultrastructural injuries, including mitochondrial swelling, mitochondrial cristae rupture, and mitochondrial cavitation, were observed, especially in the 30 mW/cm2 microwave-exposed group. Generally, multifrequency microwaves decreased white blood cells, as well as lymphocytes, monocytes, and neutrophils, in peripheral blood, from 7 d to 28 d after exposure. Microwaves with an average density of 30 mW/cm2 produced much more significant inhibitory effects on immune cells. Moreover, multifrequency microwaves at 10 and 30 mW/cm2, but not 5 mW/cm2, reduced the serum levels of several cytokines, such as interleukin-1 alpha (IL-1α), IL-1β, interferon γ (IFN-γ) and tumor necrosis factor α (TNF-α), at 7 d and 14 d after exposure. We also found similar alterations in immunoglobulins (Igs), IgG, and IgM in serum. However, no obvious changes in complement proteins were detected. In conclusion, multifrequency microwave exposure of 1.5 GHz and 2.8 GHz caused both structural injuries of immune tissues and functional impairment in immune cells. Therefore, it will be necessary to develop an effective strategy to protect people from multifrequency microwave-induced immune suppression.
A Combined AHP-PROMETHEE Approach for Portfolio Performance Comparison
Authors: Sikalo Mirza , Arnaut-Berilo Almira , Delalic Adela
Published: March 2023

Comparing portfolio performance is complex due to the fact that each model is dominant in its own risk space. Since there is no single dominant performance measure, the research problem is how to incorporate several different measures into a performance evaluation model that allows portfolios to be ranked. In this regard, the objective of this study was to develop a new comprehensive method for comparing portfolio performance based on multiple-criteria decision-making (MCDM). This paper proposes an integrated approach for stock market decision making that combines the Analytic Hierarchy Process (AHP) and the Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE), which allow hierarchical evaluation of a finite number of alternatives according to different criteria. This hybrid approach is especially advantageous, utilizing the strengths of both individual methods. AHP enables the decomposition of a complex problem into its constituent parts and the determination of weights for criteria, while the PROMETHEE method allows the investor to determine the preference function, complete ranking, and analysis of the robustness of the results. For the MCDM model in this study, different dimensions of performance measures are considered criteria: return measures, risk measures, stability measures, and predictability measures. The methodology has been applied in comparing real portfolios selected on the basis of different risk measures. For this purpose, weekly return data were used for a sample of stocks that are components of the STOXX Europe 600 Index for the period 2000–2020. In addition, a sensitivity analysis is performed to investigate the strength of the results of this method. It suggests that the simultaneous consideration of different performance measures and the investor’s attitude towards the importance of these measures are notably important in the portfolio efficiency estimation process.
SiMYBS3, Encoding a Setaria italica Heterosis-Related MYB Transcription Factor, Confers Drought Tolerance in Arabidopsis
Authors: Liu Xin , Zhang Shuai , Sun Mengbo , Guo Yurong , Zhao Shaoxing , Zhou Xutao , Bai Xionghui , Dai Keli , Li Huixia , Yuan Xiangyang , Shi Weiping , Guo Pingyi , Guo Jie
Published: March 2023

Drought is a major limiting factor affecting grain production. Drought-tolerant crop varieties are required to ensure future grain production. Here, 5597 DEGs were identified using transcriptome data before and after drought stress in foxtail millet (Setaria italica) hybrid Zhangza 19 and its parents. A total of 607 drought-tolerant genes were screened through WGCNA, and 286 heterotic genes were screened according to the expression level. Among them, 18 genes overlapped. One gene, Seita.9G321800, encoded MYBS3 transcription factor and showed upregulated expression after drought stress. It is highly homologous with MYBS3 in maize, rice, and sorghum and was named SiMYBS3. Subcellular localization analysis showed that the SiMYBS3 protein was located in the nucleus and cytoplasm, and transactivation assay showed SiMYBS3 had transcriptional activation activity in yeast cells. Overexpression of SiMYBS3 in Arabidopsis thaliana conferred drought tolerance, insensitivity to ABA, and earlier flowering. Our results demonstrate that SiMYBS3 is a drought-related heterotic gene and it can be used for enhancing drought resistance in agricultural crop breeding.
Construction of a Human Resource Sharing System Based on Blockchain Technology
Authors: Zhu Guoyao , Gu Zhenyu , Dai Yonghui
Published: March 2023

Human resource data sharing is very important for the cooperation of human resource institutions. Since the human resource data-sharing service needs to take into account the needs of individuals and talent service institutions, it faces issues such as the security of information sharing and the traceability of information. Therefore, this paper constructs a human resource data-sharing service system based on blockchain technology. Its trust mechanism is based on the Fabric alliance chain, and the system makes full use of its advantages of decentralization and consensus. Our research mainly includes data sharing architecture design, consensus mechanism analysis, smart contract design, data sharing process, and blockchain construction. The contribution of this paper is mainly in two aspects. On the one hand, it explores the trust mechanism of human resource data sharing and gives the scheme of the Fabric alliance chain. On the other hand, the overall architecture and smart contract design are given on the construction of the blockchain, which provides a reference for future research on human resource data sharing.
Adapting Off-the-Shelf Speech Recognition Systems for Novel Words
Authors: Fadel Wiam , Bouchentouf Toumi , Buvet Pierre-André , Bourja Omar
Published: March 2023

Current speech recognition systems with fixed vocabularies have difficulties recognizing Out-of-Vocabulary words (OOVs) such as proper nouns and new words. This leads to misunderstandings or even failures in dialog systems. Ensuring effective speech recognition is crucial for the proper functioning of robot assistants. Non-native accents, new vocabulary, and aging voices can cause malfunctions in a speech recognition system. If this task is not executed correctly, the assistant robot will inevitably produce false or random responses. In this paper, we used a statistical approach based on distance algorithms to improve OOV correction. We developed a post-processing algorithm to be combined with a speech recognition model. In this sense, we compared two distance algorithms: Damerau–Levenshtein and Levenshtein distance. We validated the performance of the two distance algorithms in conjunction with five off-the-shelf speech recognition models. Damerau–Levenshtein, as compared to the Levenshtein distance algorithm, succeeded in minimizing the Word Error Rate (WER) when using the MoroccanFrench test set with five speech recognition systems, namely VOSK API, Google API, Wav2vec2.0, SpeechBrain, and Quartznet pre-trained models. Our post-processing method works regardless of the architecture of the speech recognizer, and its results on our MoroccanFrench test set outperformed the five chosen off-the-shelf speech recognizer systems.
Influence of Corrosion on Dynamic Behavior of Pedestrian Steel Bridges—Case Study
Authors: Barrios Susana , Guzmán Andrés , Ortiz Albert
Published: March 2023

Corrosion directly affects the structural stiffness of a steel element, reducing the thickness, thus inertia, due to the gradual deterioration of the material. Quickly identifying corrosion damage to the stiffness of a steel structure is a challenge in coastal environments since corrosion progresses rapidly, and traditional methods of inspection and diagnosis are time-consuming and costly. This is an important issue; therefore, characterization of the corrosion level represents a key element in making decisions regarding maintenance or structural integrity. This work estimates the relationship between the corrosion level in steel structures and their dynamic parameters using ambient vibration records. It comprises the characterization of the dynamic behavior and corrosion state of three full-scale pedestrian bridges with similar geometry, material, and structural configuration characteristics but with significant differences in the degree of deterioration. The structures were instrumented with piezoelectric sensors connected to a portable data acquisition system; the recorded information was analyzed with optimization algorithms in Python based on the power spectral density (PSD) of the vibrations of each bridge. The parameters obtained related to the degree of corrosion determine the incidence of the level of deterioration in the structural behavior, thus involving changes in its stiffness and mass.
Synthesis and Characterization of Pt(II) and Pd(II) Complexes with Planar Aromatic Oximes
Authors: Meadows Mikala , Yang Lei , Turner Cody , Berezin Mikhail , Tyukhtenko Sergiy , Gerasimchuk Nikolay
Published: March 2023

A series of four Werner-type complexes of Pd(II) and Pt(II) with planar, isomeric conjugated aromatic naphtoquinone oximes were synthesized for the first time. These ligands were 1-oxime-2-naphtoquinone (HL1) and 2-oxime-1-napthoquinone (HL2). Compounds were characterized using thermal analysis, spectroscopic methods, and X-ray analysis. TG/DSC data were collected for pure starting organic ligands, their complexes, and indicated vigorous exothermic decomposition with at ~155 °C for starting HL and ~350 °C for transition metal complexes. Crystal structures for two Pt compounds with 2-oxime-1-quinone were determined and revealed the formation of the cis-geometry complexes and incorporation of molecules of stoichiometric solvents in the lattice: acetonitrile and nitrobenzene. Both solvents of crystallization displayed attractive interactions between their C-H groups and the oxygen atoms of the nitroso groups in complexes, leading to short distances in those fragments. Despite the presence of solvents of inclusion, the overall structure motifs in both compounds represent 1D columnar coordination polymer, in which the PtL2 units are held together via metallophilic interactions, thereby forming ‘Pt-wires’. The Hirshfield surface analysis was performed for both crystallographically characterized complexes. The results showed intermolecular π–π stacking and Pt–Pt interactions among the planar units of both complexes. In addition, the analysis also verified the presence of hydrogen bonding interactions between the platinum unit and solvent molecules. Solid bulk powdery samples of both PtL12 and PtL22 demonstrated pronounced photoluminescence in the near infrared region of spectrum at ~980 nm, being excited in the range of 750–800 nm. The NIR emission was observed only for Pt-complexes and not for pure starting organic ligands or Pd-complexes. Additionally, synthesized Pt-naphtoquinone oximes do not show luminescence in solutions, which suggests the importance of a 1D ‘metal wire’ structure for this process.
Ischemic Stroke and Savings in Time to Achieve Functional Recovery: Experience from NeuroAiD
Authors: Venketasubramanian Narayanaswamy , Pokharkar Yogesh , Chai Jia Hui , Chen Christopher Li Hsian
Published: March 2023

Despite recent progress with revascularisation interventions after acute ischemic stroke, many patients remain disabled after stroke. Using data from a multi-centre, randomised, double-blind, placebo-controlled trial of a neuro-repair treatment (NeuroAiD/MLC601) with a long-term follow-up, we analysed the savings in time to functional recovery, measured by a modified Rankin Scale (mRS) score of 0 or 1, in patients receiving a 3-month oral course of MLC601. Analysis of time to recovery was assessed by a log-rank test and hazard ratios (HRs) adjusted for prognosis factors. A total of 548 patients with baseline NIHSS scores 8–14, mRS scores ≥ 2 at day 10 post-stroke, and at least one mRS assessment on or after month 1 were included in the analysis (placebo = 261; MLC601 = 287). Time to functional recovery was significantly shortened for patients receiving MLC601 versus patients receiving placebo (log-rank test: p = 0.039). This result was confirmed by Cox regression adjusting for the main baseline prognostic factors (HR: 1.30 [0.99, 1.70]; p = 0.059) and was more pronounced in patients with additional poor prognosis factors. The Kaplan–Meier plot showed that approximately 40% cumulative incidence of functional recovery was achieved within 6 months after stroke onset in the MLC601 group versus 24 months in the placebo group. The main findings are that MLC601 reduced the time to achieve functional recovery, and a 40% functional recovery rate was achieved 18 months earlier compared to placebo.
Safety and Perioperative Outcomes of Laparoscopic vs. Open Hepatectomy of Central-Located Liver Lesions: A Multicenter, Propensity Score-Matched, Retrospective Cohort Study
Authors: Jin Bao , Yang Muyi , Wang Yinhan , Xu Gang , Wang Yuxin , Zhang Yuke , Liu Yitong , Niu Xinming , Liu Xiao , Wan Xueshuai , Yang Huayu , Lu Xin , Sang Xinting , Mao Yilei , Hong Zhixian , Du Shunda
Published: March 2023

Background: Short-term outcomes of laparoscopic hepatectomy of central-located liver lesions (LHCL) compared with traditional open hepatectomy of central-located liver lesions (OHCL) remain unclear. The aim of this study was to explore the safety and efficacy of LHCL. Methods: A retrospective analysis was performed on 262 patients who underwent hepatectomies involving resections of liver segment II, IV or VIII from January 2015 to June 2021 in two institutions. Patients in the LHCL group were matched in a 1:2 ratio to patients in the OHCL group. Results: After propensity score-matched (PSM) analysis, 61 patients remained in the LHCL group and 122 patients were in the OHCL group. What needs to be mentioned is that although not significant, patients in the OHCL group had increased lesion size (4.3 vs. 3.6 cm, p = 0.052), number (single/multiple, 84.8%/15.2% vs. 93.4%/6.6%, p = 0.097), and number of liver segments involved (one/two/three, 47.3%/42.0%/10.7% vs. 57.4%36.1%/10.7%, p = 0.393). To ensure surgical safety, fewer patients in the LHCL group underwent vascular exclusion than those in the OHCL group (p = 0.004). In addition, LHCL was associated with lower blood loss (p = 0.001) and transfusion requirement (p = 0.004). In terms of short-term outcomes, the LHCL group had significantly lower levels of peak ALT (p < 0.001), peak DBIL (p = 0.042), peak PT (p = 0.012), and higher levels of bottom ALB (p = 0.049). Moreover, the LHCL group demonstrated quicker postoperative recovery, which was represented by shorter time to first flatus, time to oral intake, time to drain off, and hospital stay (all p < 0.001). Importantly, the LHCL group had a significantly reduced occurrence of postoperative complications (p < 0.001) and similar R0 resection rates (p = 0.678) when compared to the OHCL group. Conclusion: LHCL is associated with increased safety and better perioperative outcomes and thus could be recommended for patients with central space-occupying liver lesions when appropriately selecting the surgical procedure according to the total tumor burden and carefully handled by experienced surgeons. From the experience of our center, LHCL could be performed to solitary lesion involving liver segment IV/V/VIII, <5 cm, with good safety and feasibility.
Hepatic Resection in Patients with Colo-Rectal Liver Metastases: Surgical Outcomes and Prognostic Factors of Single-Center Experience
Authors: Pagani Matteo , De Vincenti Rosita , Cecchi Carolina , Apollinari Alice , Pesi Benedetta , Leo Francesca , Giannessi Sandro , Fedi Massimo
Published: March 2023

Introduction: Surgical resection has a fundamental role in increasing the chance of survival in patients with colorectal liver metastases. The guidelines have been modified and expanded in time in order to increase the number of patients that can benefit from this treatment. The aim of this study is to analyze the main prognostic factors related to overall and disease-free survival of a series of consecutive patients undergoing liver resection for colorectal liver metastases (CRLM). Materials and Methods: A retrospective review of patients undergoing liver resection for CRLM between April 2018 and September 2021 was performed. Clinical data and laboratory parameters were evaluated using the log-rank test. OS and DFS were estimated using the Kaplan-Meier method. Results: A retrospective study on 75 patients who underwent liver resection for CRLM was performed. The OS and DFS at 1 and 3 years were 84.3% and 63.8% for OS, 55.6% and 30.7% for DFS, respectively. From the analysis of the data, the most significant results indicate that: patients with a lower CEA value <25 ng/mL had an OS of 93.6% and 80.1% at 1 and 3 years, with an average of 36.7 months (CI 95% 33.1–40.3); moreover, patients with a value equal to or greater than 25 ng/mL had a 1-year survival equal to 57.4%, with an average of 13.8 months (CI 95% 9.4–18.2) (p < 0.001); adjuvant chemotherapy increases by 3 years the overall survival (OS: 68.6% vs. 49.7%) (p = 0.013); localization of the primary tumor affects OS, with a better prognosis for left colon metastases (OS at 42 months: 85.4% vs. 42.2%) (p value = 0.056); patients with stage T1 or T2 cancer have a better 3 years OS (92.9–100% vs. 49.7–56.3%) (p = 0.696), while the N0 stage results in both higher 3 years OS and DFS than the N + stages (OS: 87.5% vs. 68.5% vs. 24.5%); metachronous metastases have a higher 3 years OS than synchronous ones (80% vs. 47.4%) (p = 0.066); parenchymal sparing resections have a better 3 years DFS than anatomical ones (33.7% vs. 0%) (p = 0.067); a patient with a parenchymal R1 resection has a much worse prognosis than an R0 (3 years OS: 0% vs. 68.7%) (p < 0.001). Conclusions: CEA value of less than 25 ng/mL, localization of the primary tumor in the left colon, primary tumor in stage T1/2 and N0, metachronous presentation, R0 resection, fewer than four metastases, and use of adjuvant chemotherapy are all parameters that in our analysis have shown a correlation with a better prognosis; moreover, the evaluation of the series is in line with the latest evidence in the literature in defining the non-inferiority of minimally invasive and parenchymal sparing treatment compared to the classic laparotomic approach with anatomic resection.
Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review
Authors: Lynch Daniel G. , Narayan Raj K. , Li Chunyan
Published: March 2023

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Despite extensive research efforts, the majority of trialed monotherapies to date have failed to demonstrate significant benefit. It has been suggested that this is due to the complex pathophysiology of TBI, which may possibly be addressed by a combination of therapeutic interventions. In this article, we have reviewed combinations of different pharmacologic treatments, combinations of non-pharmacologic interventions, and combined pharmacologic and non-pharmacologic interventions for TBI. Both preclinical and clinical studies have been included. While promising results have been found in animal models, clinical trials of combination therapies have not yet shown clear benefit. This may possibly be due to their application without consideration of the evolving pathophysiology of TBI. Improvements of this paradigm may come from novel interventions guided by multimodal neuromonitoring and multimodal imaging techniques, as well as the application of multi-targeted non-pharmacologic and endogenous therapies. There also needs to be a greater representation of female subjects in preclinical and clinical studies.
Factors Associated with ADL Dependence in Nursing Home Residents with Korsakoff’s Syndrome and Other Alcohol-Related Disorders: An Explorative Cross-Sectional Study
Authors: Böhner Eline S. , Spek Bea , Joling Karlijn J. , Zwaagstra Yvonne , Gerridzen Ineke J.
Published: March 2023

Difficulties in performing activities of daily living (ADL) are common in patients with Korsakoff‘s syndrome (KS). The aim of this study was to identify factors associated with ADL dependence in nursing home residents with KS. This exploratory, cross-sectional study included 281 residents with KS from 9 specialized nursing homes in the Netherlands. We examined demographic, cognitive, somatic, and (neuro)psychiatric characteristics. ADL dependence was assessed with the Inter-RAI ADL Hierarchy Scale. Multivariable logistic regression analyses were used to identify factors associated with ADL dependence. Cognitive impairment (odds ratio [OR] = 7.46; 95% confidence interval [CI] = 2.10–30.5), female gender (OR = 3.23; CI, 1.21–8.78), staying in a nursing home for ≥5 years (OR = 3.12; CI, 1.24–8.33), and impaired awareness (OR = 4.25; CI, 1.56–12.32) were significantly associated with higher ADL dependence. Chronic obstructive pulmonary disease (COPD) was significantly associated with lower ADL dependence (OR = 0.31; CI, 0.01–0.84). The model explained 32% of the variance. The results suggest that when choosing interventions aimed at improving ADL functioning, special attention should be paid to residents living more than five years in the nursing home, with a female gender, with more severe cognitive impairments, and/or with COPD.
Vertigo in the Elderly: A Systematic Literature Review
Authors: Fancello Virginia , Hatzopoulos Stavros , Santopietro Giuseppe , Fancello Giuseppe , Palma Silvia , Skarżyński Piotr Henryk , Bianchini Chiara , Ciorba Andrea
Published: March 2023

Background: Dizziness and vertigo are among the most prevalent complaints in the elderly and have a major negative influence on (i) the perception of the quality of life; and (ii) the risk of falling. Due to population aging, particularly in wealthy nations, vertigo represents a growing issue and a serious public health concern. In order to approach the patient correctly and to offer the best treatment options, it is mandatory to identify vertigo’s underlying causes. The aim of this paper was to identify the different etiologies of vertigo and possibly their frequency in the elderly population, by reviewing the scientific literature of the last decade (2012–2022). Methods: A systematic review was performed according to PRISMA guidelines, searching the Medline database from January 2012 through to December 2022. The search identified 1025 candidate papers, but after the application of specific selection criteria, only five were considered for further analysis. Results: A total of 2148 elderly patients (60–90 y old) presenting with vertigo were reported in the selected papers. A total of 3404 conditions were identified as the cause of vertiginous symptoms, (some patients presented multiple etiologies). All major diagnoses were categorized into different subgroups: the most common origin of vertigo was represented by audio-vestibular disorders (28.4%), followed by cardiovascular (20.4%) and neurological diseases (15.1%). Furthermore, 9.1% of patients were diagnosed with psychiatric conditions, whilst ophthalmologic and musculoskeletal disorders accounted for 7.5% and 6.3% of the cases respectively. Medication adverse effects and metabolic-related diseases were also considered among the causes. For 3.4% of cases the etiology remains unclear. Conclusions: Audio-vestibular disorders represent the most frequent cause of vertigo in the elderly. The etiologies affecting the vertigo patient must be defined in order to identify potential life-threatening conditions, such as cardiovascular and neurological disorders, which according to the data of this review constitute the second and third common causes of vertigo. A multidisciplinary strategy, involving different specialists (such as ENTs, Neurologists, Cardiologists, Geriatricians) is recommended for the correct assessment of these disorders.
Roots and Root Canals Characterization of Permanent Mandibular Premolars Analyzed Using the Cone Beam and Micro Computed Tomography—A Systematic Review and Metanalysis
Authors: Karobari Mohmed Isaqali , Assiry Ali A. , Lin Galvin Sim Siang , Almubarak Hussain , Alqahtani Saleh Ali , Tasleem Robina , Mustafa Mohammed , Luke Alexander Maniangat , Shetty Krishna Prasad , Noorani Tahir Yusuf , Scardina Giuseppe A.
Published: March 2023

This current paper aims to review the literature on the root canal configuration (RCC) and root structure of permanent mandibular premolars. To find the published scientific literature on the RCC of mandibular premolars up to July 2022, a systematic search of four electronic databases was performed. The studies were selected, rendering to a predetermined point of reference: “mandibular 2nd premolar”, “root and canal system”, “morphology of root and canal”, “root and canal configuration”, and “morphology”, along with “anatomy” and “mandibular premolars”. Cross-referencing along with screening through the bibliographies of the chosen articles resulted in the identification of further studies. In the current study, we examined 30 different articles, and we chose them based on the quality of research investigations. From 3471 retrieved studies, a total of 15981 mandibular 2nd premolars were observed in 30 studies. The mean JBI score for studies assessing the structure of the root, as well as the root canal of the mandibular 2nd premolar, was 7.78 ± 0.81. We have found a pooled prevalence of 91.82% for Vertucci class I root canal morphology and 78.63% pooled prevalence of single-rooted mandibular second premolar. A total of 8677 mandibular 1st premolars were observed in 22 studies. The mean JBI score for studies assessing the structure and anatomy of the root, as well as root canal of mandibular 1st premolar, was 7. 95 ± 0.85. We have found a pooled prevalence of 74.34% for Vertucci class I root canal morphology and 85.20% pooled prevalence of single-rooted mandibular 1st premolar. Mandibular first and second premolars were mostly single-rooted teeth (89.5–100%). The most frequently seen RCC is a 1-1-2-/2 (type V–Vertucci’s), followed by 1-1-2-/1 (type IV– Vertucci’s; type III–Weine’s), and finally RCC 2-2-2-1 (type IV–Vertucci’s; type III–Weine’s). Presently, the imaging of CBCT is the most used research approach for studying Mn2Ps’ structural characteristics.
An Attentional Bias Modification Task, through Virtual Reality and Eye-Tracking Technologies, to Enhance the Treatment of Anorexia Nervosa
Authors: Meschberger-Annweiler Franck-Alexandre , Ascione Mariarca , Porras-Garcia Bruno , Ferrer-Garcia Marta , Moreno-Sanchez Manuel , Miquel-Nabau Helena , Serrano-Troncoso Eduardo , Carulla-Roig Marta , Gutiérrez-Maldonado José
Published: March 2023

Mirror exposure therapies (METs) have been shown to be effective in reducing body image disturbances through the habituation process. Virtual reality (VR) combined with eye-tracking techniques can provide innovative solutions to some of METs’ limitations reported with patients with anorexia nervosa (AN), especially the negative influence of body-related attentional bias (AB). This pilot study aimed to assess the preliminary efficacy of a new VR-based AB modification task (ABMT) among healthy women and the procedure’s user experience. AB levels towards weight- and non-weight-related body parts, using complete fixation time (CFT) and number of fixations (NF), were assessed throughout the ABMT procedure (300 trials). The user experience was evaluated at the end of the procedure. The results showed that VR-based ABMT was effective in reducing AB significantly after 150 trials for both CFT- and NF-based measures, although 225 trials were necessary to get the same result for women with an NF initially more oriented towards weight-related body parts. Overall, the software received a “C-rating” on a scale from “A” (most usable) to “F” (least usable). These results provide evidence of the opportunity to use a VR-based ABMT procedure to reduce AB and improve existing treatments for AN.