bluuebunny/crossref_metadata_2025 huggingface dataset:
Water quality assessment of a tropical river using water quality index (WQI), multivariate statistical techniques and GIS
Authors: Shil Sanjoy , Singh Umesh Kumar , Mehta Pankaj
Published: October 2019

Mahananda River is an important river in India and Bangladesh, as the people of both the countries use the water extensively, without sufficient and reliable information about water qualities and pollution status. The purpose of this study is to evaluate the water quality of the river and to analyse the suitability for drinking, agricultural and industrial uses. This is why this study on the Mahananda River is extremely important for the region. For this study, samples from fourteen sampling stations were collected in pre-monsoon and post-monsoon seasons in 2016 and water quality index (WQI), agriculture and industry-related indices were computed. WQI values designated two sampling stations out of fourteen sampling stations as ‘very bad’ category and another two sampling stations as ‘bad’ category. The pH values of some sampling stations slightly exceeded the upper permissible limit. USSL diagram analysis classified two samples of pre-monsoon season in C2S1 category which indicates a medium salinity and low sodium water. Magnesium hazard values of four sampling stations are above 50% suggesting not suitable for irrigation. However, some indices like sodium per cent, residual sodium carbonate and residual sodium bicarbonate, Kelly’s index, permeability index and potential salinity allow the water for use in irrigation purposes. Langelier Saturation Index and aggressive index values designate the water as moderately aggressive or non-aggressive. Ryznar Stability Index values designate the water as ‘aggressive’ or ‘very aggressive’ indicating unsuitability for industrial uses. Sampling stations S-1, S-2, S-8 and S-14 need special attention.
Curvature Sensor Based on a Long-Period Grating in a Fiber Ring Resonator Interrogated by an OTDR
Authors: Magalhães Regina , Silva Susana , Frazão Orlando
Published: October 2019

The proposed technique demonstrates a fiber ring resonator interrogated by an optical time domain reflectometer (OTDR), for intensity sensing. By using this methodology, a cavity round trip time of 2.85 μs was obtained. For a proof of concept, a long-period grating was inserted in the resonant cavity operating as a curvature sensing device. A novel signal processing approach was outlined, regarding to the logarithmic behavior of the OTDR. Through analyzing the experimental results, an increase in the measured sensitivities was obtained by increasing applied bending. With curvatures performed from 1.8 m−1 to 4.5 m−1, the sensitivity values ranged from 2.94 dB·km−1 to 5.15 dB·km−1. In its turn, the sensitivities obtained presented a linear behavior when studied as a function of the applied curvature, following a slope of 0.86×10−3 dB. The advantages of applying this technique were also discussed, demonstrating two similar fiber rings multiplexed in a series of configurations.
Characterization of dendritic cell subtypes in human cord blood by single-cell sequencing
Authors: Jin Xiaoyang , Meng Lingyuan , Yin Zhao , Yu Haisheng , Zhang Linnan , Liang Weifeng , Wang Shouli , Liu Guanyuan , Zhang Liguo
Published: October 2019

Dendritic cells (DCs) are professional antigen-presenting cells (APCs). The key functions of DCs include engulfing, processing and presenting antigens to T cells and regulating the activation of T cells. There are two major DC subtypes in human blood: plasmacytoid DCs (pDCs) and conventional DCs. To define the differences between the adult and infant immune systems, especially in terms of DC constitution, we enriched DCs from human cord blood and generated single-cell RNA sequencing data from about 7000 cells using the 10x Genomics Single Cell 3′ Solution. After incorporating the differential expression analysis method in our clustering process, we identified all the known dendritic cell subsets. Interestingly, we also found a group of DCs with gene expression that was a mix of megakaryocytes and pDCs. Further, we verified the expression of selected genes at both the RNA level by PCR and the protein level by flow cytometry. This study further demonstrates the power of single-cell RNA sequencing in dendritic cell research.
The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management
Authors: Sun Chun‐Hui , Li Bin‐Bin , Wang Bo , Zhao Jing , Zhang Xiao‐Ying , Li Ting‐Ting , Li Wen‐Bing , Tang Di , Qiu Miao‐Juan , Wang Xin‐Cheng , Zhu Cheng‐Ming , Qian Zhi‐Rong
Published: October 2019

Colorectal cancer (CRC) is a common malignant tumor that affects people worldwide. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue; many studies have indicated that F. nucleatum is closely related to the colorectal carcinogenesis. In this review, we provide the latest information to reveal the related molecular mechanisms. The known virulence factors of F. nucleatum promote adhesion to intestinal epithelial cells via FadA and Fap2. Besides, Fap2 also binds to immune cells causing immunosuppression. Furthermore, F. nucleatum recruits tumor‐infiltrating immune cells, thus yielding a pro‐inflammatory microenvironment, which promotes colorectal neoplasia progression. F. nucleatum was also found to potentiate CRC development through toll‐like receptor 2 (TLR2)/toll‐like receptor 4 (TLR4) signaling and microRNA (miRNA)‐21 expression. In addition, F. nucleatum increases CRC recurrence along with chemoresistance by mediating a molecular network of miRNA‐18a*, miRNA‐4802, and autophagy components. Moreover, viable F. nucleatum was detected in mouse xenografts of human primary colorectal adenocarcinomas through successive passages. These findings indicated that an increased number of F. nucleatum in the tissues is a biomarker for the diagnosis and prognosis of CRC, and the underlying molecular mechanism can probably provide a potential intervention treatment strategy for patients with F. nucleatum‐associated CRC.
Sex Education for Transgender and Non-Binary Youth: Previous Experiences and Recommended Content
Authors: Haley Samantha G. , Tordoff Diana M. , Kantor Alena Z. , Crouch Julia M. , Ahrens Kym R.
Published: October 2019

Background

Transgender and non-binary (TNB) youth face disparities in sexual health risks compared with cisgender peers. Comprehensive sex education programs have the potential to result in delayed sexual debut, increased condom and contraceptive use, and reduced sexual risk-taking; however, little research has explored the specific sex education needs of TNB youth.

Aim

To use insights from TNB youth, parents of TNB youth, and healthcare affiliates to understand deficits in sex education experienced by TNB youth, and to elicit recommended content for a comprehensive and trans-inclusive sex education curriculum.

Methods

We conducted 21 in-depth interviews with non-minor TNB youth (n = 11) and with parents (n = 5) and healthcare affiliates (n = 5) of TNB youth recruited from Seattle Children’s Gender Clinic and local TNB community listerv readerships. Data was analyzed using theoretical thematic analysis.

Outcomes

Participants described prior sex education experiences and content needs of TNB youth.

Results

Participants described 5 key sources where TNB youth received sexual health information: school curricula, medical practitioners, peers, romantic partners, and online media. Inapplicability of school curricula and variable interactions with medical practitioners led youth to favor the latter sources. 8 content areas were recommended as important in sex education for TNB youth: puberty-related gender dysphoria, non-medical gender-affirming interventions, medical gender-affirming interventions, consent and relationships, sex and desire, sexually transmitted infection prevention, fertility and contraception, and healthcare access.

Clinical Implications

Dependence on potentially inaccurate sex education sources leaves TNB youth vulnerable to negative outcomes, including sexually transmitted infections, pregnancy, unsanitary/unsafe sex toy use, and shame about their body or sexual desires.

Strengths & Limitations

Strengths included capturing perspectives of an underserved population using open-ended interview questions, which allowed topics of greatest importance to participants to arise organically. Limitations included a sample size of 21 participants, and racial and geographic homogeneity of youth and parent participants. Only 1 author identifies as TNB. One-on-one interview methods may have omitted participants who would otherwise have been willing to share their perspective in a more impersonal format.

Conclusion

This study demonstrates that TNB youth have unique sex education needs that are not well covered in most sexual health curricula. Recommended content for this population includes standard sex education topics that require trans-inclusive framing (eg, contraception), topics specific to TNB youth (eg, gender-affirming medical interventions), and topics absent from standard curricula that warrant universal teaching (eg, information on consent as it relates to sex acts aside from penile-vaginal sex).
False Alarm
Authors: Porter Ethan , Wood Thomas J.
Published: October 2019

Americans are not invulnerable to factual information. They do not 'backfire'; facts do not make them less accurate. Instead, they become more accurate, even when corrections target co-partisans. Corrections of fake news yield similar results. Among Republicans, Trump's misstatements are less susceptible to corrections than identical misstatements attributed to other Republicans. While we do not observe facts affecting attitudes, multiple instances of misinformation can increase approval of the responsible politician - but corrections can reduce approval by similar amounts. While corrections do not eliminate false beliefs, they reduce the share of inaccurate beliefs among subjects in this study nearly in half.
Putaminal Diffusion Restriction in a Case of Methanol Toxicity with Clinical Recovery
Authors: Quinn Matthew P. , Bursztyn Lulu LCD , Sharma Manas
Published: October 2019

A 32-year-old male presented to the emergency department for confusion, dyspnea, and a “white out” of his central vision over the preceding 24 hours. The patient had recently consumed a bottle of alcohol purchased overseas. Bloodwork revealed a severe metabolic acidosis (pH 6.90) and a critically high methanol level of 28.9 mmol/l. Shortly after presentation, the patient went into respiratory failure and became comatose. He was intubated and admitted to the ICU.
Promoting interdisciplinary research to respond to public health crises: The response of the Columbia University CTSA to the opioid crisis
Authors: Humensky Jennifer L. , Abedin Zainab , Muhammad Kawthar , McClave Michelle , Torres Tiara , DiMaria Elisabeth Swift , Reilly Muredach P. , Pincus Harold Alan
Published: October 2019

Effectively addressing public health crises requires dynamic and nimble interdisciplinary collaborations across the translational spectrum, from bench to clinic to community. The Clinical and Translational Science Award (CTSA) Program hubs are uniquely suited to facilitate interdisciplinary collaborations across universities and academic medical centers. This paper describes the activities at the Columbia University CTSA Program hub to address a current public health crisis, the opioid epidemic. Columbia’s CTSA Program hub led a three-phase approach, based on the Conceptual Model of Transdisciplinary Scientific Collaboration as described by Stokols et al.: (1) a university-wide planning and brainstorming phase to identify key leaders across many domains who are influential in addressing the opioid epidemic, (2) a campus-wide and community outreach to identify all interested parties, and (3) ongoing targeted support for collaboration development. Preliminary metrics of success are interdisciplinary collaborations and grant funding. We describe recent examples of how interdisciplinary collaboration, academic-community partnership, and pilot funding contributed to the development and funding of innovative interdisciplinary research, including the New York site of the HEALing Communities initiative. The processes are now being used to support interdisciplinary approaches for other translational public health issues.
Design and manufacture of hybrid metal composite structures using functional tooling made by additive manufacturing
Authors: Türk Daniel-Alexander , Rüegg Fabian , Biedermann Manuel , Meboldt Mirko
Published: October 2019

This paper presents a novel manufacturing technique for complex-shaped, hybrid metal composite structures leveraging the design freedom of additive manufacturing (AM). The key novelty of this research is an approach for an autoclave-suitable and removable tooling, which consists of a 3D-printed functional shell and a structural filler material. In this process, a layup shell is produced with AM and filled with a temperature-resistant curing support to form a removable inner tooling. The functional shell has integrated design features for the positioning and the fixation of metallic interface elements and is removed after curing through integrated breaking lines. The feasibility of this manufacturing technique is demonstrated by fabricating a novel lightweight structure for the hydraulic quadruped (HyQ) robot. Selective laser sintering (SLS) was used to produce the functional shell tooling. Titanium interface elements made via selective laser melting (SLM) were assembled to the shell and co-cured to carbon fiber using an autoclave prepreg process. The resulting multi-material structure was tested in ultimate strength and successfully operated on the HyQ robot. Weight savings of 55% compared to a reference design and the mechanical viability of the multi-material structure indicate that the proposed manufacturing technique is appropriate for individualized hybrid composite structures with complex geometries.
Langmuir turbulence and filament frontogenesis in the oceanic surface boundary layer
Authors: Sullivan Peter P. , McWilliams James C.
Published: October 2019

Submesoscale currents, small-scale turbulence and surface gravity waves co-exist in the upper ocean and interact in complex ways. To expose the couplings, the frontogenetic life cycle of an idealized cold dense submesoscale filament interacting with upper ocean Langmuir turbulence is investigated in large-eddy simulations (LESs) based on the incompressible wave-averaged equations. The simulations utilize large domains and fine meshes with $6.4\times 10^{9}$ grid points. Case studies are made with surface winds or surface cooling with waves oriented in across-filament (perpendicular) or down-filament (parallel) directions relative to the two-dimensional filament axis. The currents $u$, $v$ and $w$ are aligned with the across-filament, down-filament and vertical directions, respectively. Frontogenesis is induced by across-filament Lagrangian secondary circulations in the boundary layer, and it is shown to be strongly impacted by surface waves, in particular the propagation direction relative to the filament axis. In a horizontally heterogeneous boundary layer, surface waves induce both mean and fluctuating Stokes-drift vortex forces that modify a linear, hydrostatic turbulent thermal wind (TTW) approximation for momentum. Down-filament winds and waves are found to be especially impactful, they significantly reduce the peak level of frontogenesis by fragmenting the filament into primary and secondary down-welling sites in a broad frontal zone over a width ${\sim}500~\text{m}$. At peak frontogenesis, opposing down-filament jets $\langle v\rangle$ overlie each other resulting in a vigorous vertical shear layer $\unicode[STIX]{x2202}_{z}\langle v\rangle$ with large vertical momentum flux $\langle v^{\prime }w^{\prime }\rangle$. Filament arrest is induced by a lateral shear instability that generates horizontal momentum flux $\langle u^{\prime }v^{\prime }\rangle$ at low wavenumbers. The turbulent vertical velocity patterns, indicative of coherent Langmuir cells, change markedly across the horizontal domain with both across-filament and down-filament winds under the action of submesoscale currents.
Seasonal and spatial variations in the ocean-coupled ambient wavefield of the Ross Ice Shelf
Authors: Baker Michael G. , Aster Richard C. , Anthony Robert E. , Chaput Julien , Wiens Douglas A. , Nyblade Andrew , Bromirski Peter D. , Gerstoft Peter , Stephen Ralph A.
Published: October 2019

The Ross Ice Shelf (RIS) is host to a broadband, multimode seismic wavefield that is excited in response to atmospheric, oceanic and solid Earth source processes. A 34-station broadband seismographic network installed on the RIS from late 2014 through early 2017 produced continuous vibrational observations of Earth's largest ice shelf at both floating and grounded locations. We characterize temporal and spatial variations in broadband ambient wavefield power, with a focus on period bands associated with primary (10–20 s) and secondary (5–10 s) microseism signals, and an oceanic source process near the ice front (0.4–4.0 s). Horizontal component signals on floating stations overwhelmingly reflect oceanic excitations year-round due to near-complete isolation from solid Earth shear waves. The spectrum at all periods is shown to be strongly modulated by the concentration of sea ice near the ice shelf front. Contiguous and extensive sea ice damps ocean wave coupling sufficiently so that wintertime background levels can approach or surpass those of land-sited stations in Antarctica.
Semi-static variance-optimal hedging in stochastic volatility models with Fourier representation
Authors: Di Tella Paolo , Haubold Martin , Keller-Ressel Martin
Published: October 2019

We introduce variance-optimal semi-static hedging strategies for a given contingent claim. To obtain a tractable formula for the expected squared hedging error and the optimal hedging strategy we use a Fourier approach in a multidimensional factor model. We apply the theory to set up a variance-optimal semi-static hedging strategy for a variance swap in the Heston model, which is affine, in the 3/2 model, which is not, and in a market model including jumps.
No Safe Space: Neoliberalism and the Production of Violence in the Lives of Central American Migrants
Authors: Alvarez Linda
Published: October 2019

This paper explores the ways in which neoliberal policies enacted by elites across the Northern Triangle have led to increased violence in Central America, a lived experience that continues as individuals migrate to Mexico and the United States. In this work, I examine how neoliberal polices in the region have created limited economic opportunities and means of subsistence for the poor in Central America, as well as the rise of extra-legal actors and criminal enterprises. Together these conditions leave Central Americans with no choice but to migrate north. This paper then explores the violence migrants experience as they move through Mexico. In this stage of the journey, migrant bodies are objectified and then commodified as cheap labor for the global market as well as local economies of violence. Lastly, I discuss the multiple zones of violence that migrants experience at Mexico's border with the United States. This project relies on in-depth, semi-structured interviews (n= 99) with Central American migrants over the course of 4 years (2014–18). Ultimately, I find that for Central American migrants, violence can be a seemingly inescapable reality as neoliberal forces maintain and normalize violence in order to preserve an established social order at the expense of these migrants.
WESTERWALD STONEWARE AT KELMSCOTT MANOR: MORRIS, POTTERY AND THE POLITICS OF PRODUCTION
Authors: Chitty Gill , Stocker David
Published: October 2019

Kelmscott Manor, the country home of William Morris, houses a remarkable collection of ceramics bearing a singular relationship to one of the most influential figures in Victorian cultural history. This study of Kelmscott’s collection of German stoneware reveals new interpretations of its production history and fascinating insights into its significance for the cultural context of Morris’s work. Based on a complete catalogue, the paper examines the ensemble of approximately thirty pieces of eighteenth- to nineteenth-century Westerwald stoneware, orgrès de Flandres, as it was known to Morris and his contemporaries. The Kelmscott group is the largest collection of this material known from an English historic house and has a composite and well-documented provenance. Supplementary material provided as an online appendix contains a fully illustrated, descriptive catalogue.

Westerwald pottery of the seventeenth century and earlier has been extensively studied, but its ceramics of the late eighteenth to nineteenth centuries have received little attention. Most accounts stress the simplification of vessel forms and ‘degeneration’ of decorative designs during this period, leading towards mass-productionc1900. This paper re-assesses later Westerwald output, drawing attention to a vernacular pottery tradition of significant interest in its own right. This paper suggests that it was this continuing tradition of vernacular production and its naturalistic, decorative schemes that attracted the interest of Morris throughout his adult life, from the Red House experiment to the heyday of Morris & Co. Examining his writing on creativity, the minor arts and labour, the paper interpretsgrès de Flandresas an expression of Morris’s idealisation of the relationship between labour and craft production.
EXILED TO HOLY TRINITY CHURCH, SUTTON COLDFIELD, WARWICKSHIRE: THE REFUGEE MARIAN CHOIR STALLS FROM WORCESTER CATHEDRAL
Authors: Riall Nicholas
Published: October 2019

The reign of Mary i (24 July 1553–17 November 1558) is widely seen as a disaster for both the woman herself and her devout faith. It can be argued that she did more than anyone to make England a Protestant nation. When we seek to find any trace of her patronage of the arts or of major building projects, we find that little survives. Eamon Duffy called such traces the ‘disjecta membra’. Yet each piece, each surprising survival, demonstrates an awareness of the latest fashions, embracing a forward-looking form of Renaissance arts rather than a backward-looking, conservative Gothic. To discover and emphatically assign a major new piece of work to this catalogue of relics is justifiably a cause of celebration. In 2011, Charles Tracy FSA re-assessed the Marian choir stalls now in Holy Trinity church, Sutton Coldfield (in Warwickshire), rightly calling them the ‘refugee choir stalls from Worcester’, for it was from Worcester cathedral that this magnificent suite was evicted in a fit of Victorian vandalism. In this article, the author demonstrates that these choir stalls were created through the patronage of Mary i, and their makers evoked in their creation ideas and fashions that emanated from Hans Holbein and Sebastiano Serlio, to create what is a unique set of work.
Chinese Press Perceptions of Threat: The U.S. and India, 1962
Authors: Liao Kuang-sheng , Whiting Allen S.
Published: October 2019

Area studies have been under attack for many years as lacking the
rigorous methods of disciplined inquiry such as are possessed by economics
and political science. However, in the last decade, social scientists have
attempted to bridge this academic gap. In the study of Chinese foreign
policy, for instance, Charles A. McClelland employed several statistical
methods for examining Chinese behaviour in international crises. Similarly,
Paul Smoker undertook a serial correlation analysis to examine both the
freedom of decision and interaction and reaction of the Indian and Chinese
Governments.
Franconian tones fare better as tones than as feet: a reply to Köhnlein (2016)
Authors: Gussenhoven Carlos , Peters Jörg
Published: October 2019

Köhnlein (2016) proposes to represent the Franconian tone contrast as a difference in foot structure, whereby Accent 1 appears in lexically marked syllabic trochees and Accent 2 in default moraic trochees, as an alternative to analyses with an underlying privative tone for Accent 2. After sketching the two approaches, we argue against three arguments Köhnlein advances in favour of the metrical analysis. We then show that one of the disadvantages incurred by the metrically derived tonal representations is the introduction of a novel and otherwise unsupported concept of a single tone that incorporates two morphologically different but phonologically identical tones. We also evaluate Köhnlein's (2018) more recent proposal to use the syllabic trochee to account for subtractive plurals in tonal dialects. Finally, we compare the predictive powers of the metrical and tonal analyses of the Arzbach dialect.
Breast cancer prevention in premenopausal women: role of the Mediterranean diet and its components
Authors: Laudisio Daniela , Barrea Luigi , Muscogiuri Giovanna , Annunziata Giuseppe , Colao Annamaria , Savastano Silvia
Published: October 2019

Breast cancer (BC) is a growing public health concern in most developed and developing countries. Since an increasing number of patients with BC are diagnosed before the menopause and premenopausal women show a more aggressive phenotype, there is consistent interest in promoting prevention strategies in order to reduce the incidence of BC in the premenopause. The Mediterranean diet (MD) has been reported to have beneficial effect in terms of cancer prevention. This healthy dietary pattern consists primarily of foods having important antioxidant properties along with a favourable fatty acid profile, all associated with a reduced risk of cancer. Due to the large variability in study subject characteristics, the protective role of the MD on BC still remains controversial and studies that have investigated the association between adherence to the MD and risk of BC in premenopausal women are fewer than those in postmenopausal women. In addition, the possibility that the beneficial effects of the MD are due to a single component or might more probably derive from the synergic effects of all components of the MD remains a scantly explored field. Considering the increased risk of recurrence and mortality rate of BC in premenopausal women as compared with postmenopausal women, the aim of the present report is to provide a general overview of the current evidence on the relationship between BC and the MD specifically in premenopausal women, and to emphasise the potential role of the MD as an effective measure to reduce the risk of developing BC in premenopausal women.
Simulating the impact of sodium reduction from packaged foods on population sodium intake in US adults and children
Authors: Dunford Elizabeth K , Poti Jennifer M
Published: October 2019

Objective:

To simulate the impact that Na reductions in food categories that are the largest contributors to dietary Na intake would have on population Na intake from packaged foods among US adults and children.

Design:

24 h Dietary recall data were used. For each store-bought packaged food product reported by participants, we generated sales-weighted Na content at the median and 25th percentile using Nutrition Facts Panel data from 193 195 products purchased by US households. The impact that Na reductions would have on population Na intake, overall and by sociodemographic subgroup, was examined.

Settings

US households.

Participants:

Children aged 2–18 years (n 2948) and adults aged >18 years (n 4878), 2011–2012 National Health and Nutrition Examination Survey.

Results:

Na intake from packaged foods was 1258 (se 21) mg for adults and 1215 (se 35) mg for children. Top-ten packaged food group sources contributed 67 % of Na intake. For adults and children, there was a decrease of 8·7 % (109 mg) and 8·0 % (97 mg), respectively, in Na intake if the top-ten sources reduced Na from the median to the 25th percentile. Although absolute reduction in intake varied between sociodemographic subgroups, significant differences were not observed.

Conclusions:

The study demonstrated that if Na reduction shifted the top-ten packaged food group sources of dietary Na intake from the median to 25th percentile, population Na intake would be reduced by 9 % in US adults and children. These findings will help inform the US government’s Na reduction targets, as well as policy makers’ understanding of differences in intake of critical sub-populations in the USA.
Anatomy, Histology, and Ultrastructure of Salivary Glands of the Burrower Bug,Scaptocoris castanea(Hemiptera: Cydnidae)
Authors: Cossolin Jamile Fernanda Silva , Martínez Luis Carlos , Pereira Monica Josene Barbosa , Vivan Lucia Madalena , Bozdoğan Hakan , Fiaz Muhammad , Serrão José Eduardo
Published: October 2019

The burrower bugScaptocoris castaneaPerty, 1830 (Hemiptera: Cydnidae) is an agricultural pest feeding on roots of several crops. The histology and ultrastructure of the salivary glands ofS. castaneawere described. The salivary system has a pair of principal salivary glands and a pair of accessory salivary glands. The principal salivary gland is bilobed with anterior and posterior lobes joined by a hilus where an excretory duct occurs. The accessory salivary gland is tubular with a narrow lumen that opens into the hilus near the excretory duct, suggesting that its secretion is stored in the lumen of the principal gland. The cytoplasm of the secretory cells is rich in the rough endoplasmic reticulum, secretory vesicles with different electron densities and mitochondria. At the base of the accessory gland epithelium, there were scattered cells that do not reach the gland lumen, with the cytoplasm rich in the rough endoplasmic reticulum, indicating a role in protein production. Data show that principal and accessory salivary glands ofS. castaneaproduce proteinaceous saliva. This is the first morphological description of theS. castaneasalivary system that is similar to other Hemiptera Pentatomomorpha, but with occurrence of basal cells in the accessory salivary gland.
The Effect of the Wording of Multiple Documents on Learning
Authors: Schoor Cornelia , Melzner Nadine , Artelt Cordula
Published: October 2019

Abstract. Learning from multiple documents is challenging, amongst other things, because authors often do not use the same words for the same concept. Derived from theoretical considerations and earlier research, it was assumed that different wording across multiple documents leads to higher cognitive load but can be beneficial for the learning of highly motivated students. In the present study, N = 100 university students (laypersons with regard to the topic) took part. They read two texts on the topic of depression either with the same wording or with different wording and worked on a case study. Prior knowledge, epistemic beliefs, cognitive load, motivational state during learning, and post learning knowledge were assessed. While controlling for prior knowledge, a significant interaction effect was found from wording and motivational state on post knowledge about concepts. Different wording was beneficial only for students with relatively high motivation. However, wording had no effect on cognitive load.
A Review of Wave Spectrum Models as Applied to the Problem of Radar Probing of the Sea Surface
Authors: Ryabkova M. , Karaev V. , Guo J. , Titchenko Yu.
Published: October 2019

The most common models of the wind wave spectrum are reviewed, and the compliance of the studied spectra with several fundamental criteria is estimated. These criteria are the ability to simulate diverse wave climate and agreement between model‐based calculations of the mean square slope and experimental data. The spreading function of the spectrum should also correspond to the experimentally measured Doppler spectrum, while the dependence of the radar backscatter cross section should conform to geophysical model functions for various wavelength ranges of incident electromagnetic radiation at moderate incidence angles (20–60°). An analysis has shown that none of the considered spectrum models fully satisfies all the criteria; thus, a new spectrum model for wind waves was developed. Boundary wave numbers for various wavelength ranges of incident electromagnetic radiation within the framework of a two‐scale surface model were determined for the new model. The spectrum model can be used to simulate ripple attenuation in oil slicks and to calculate the radar backscatter cross section inside slick.
Volume Flow Rate Estimation for Small Explosions at Mt. Etna, Italy, From Acoustic Waveform Inversion
Authors: Diaz‐Moreno A. , Iezzi A. M. , Lamb O. D. , Fee D. , Kim K. , Zuccarello L. , De Angelis S.
Published: October 2019

Rapid assessment of the volume and the rate at which gas and pyroclasts are injected into the atmosphere during volcanic explosions is key to effective eruption hazard mitigation. Here, we use data from a dense infrasound network deployed in 2017 on Mt. Etna, Italy, to estimate eruptive volume flow rates (VFRs) during small gas‐and‐ash explosions. We use a finite‐difference time‐domain approximation to compute the acoustic Green's functions and perform a full waveform inversion for a multipole source, combining monopole and horizontal dipole terms. The inversion produces realistic estimates of VFR, on the order of 4 × 104 m3/s and well‐defined patterns of source directivity. This is the first application of acoustic waveform inversion at Mt. Etna. Our results demonstrate that acoustic waveform inversion is a mature and robust tool for assessment of source parameters and holds potential as a tool to provide rapid estimates of VFR in near real time.
Dipole Structure of Mixed Layer Salinity in Response to El Niño‐La Niña Asymmetry in the Tropical Pacific
Authors: Guan Cong , Hu Shijian , McPhaden Michael J. , Wang Fan , Gao Shan , Hou Yinglin
Published: October 2019

The asymmetry of mixed layer salinity (MLS) anomalies in response to El Niño and La Niña events in the tropical Pacific is examined for the first time based on Argo observations and Estimating the Circulation and Climate of the Ocean simulation. The difference of MLS anomalies between El Niño and La Niña shows a dipole structure, with El Niño featuring strong negative salinity anomalies east of 160°E while La Niña shows remarkable positive salinity anomalies west of 160°E. A salinity budget analysis suggests that nonlinear zonal advection plays a dominant role in generating the asymmetric MLS structure. This dipole MLS structure acts to generate a dipole structure of barrier layer thickness and thus likely plays an important role in the development of El Niño–Southern Oscillation asymmetries in sea surface temperature.
Restoration of hand function with long-term paired associative stimulation after chronic incomplete tetraplegia: a case study
Authors: Rodionov A. , Savolainen S. , Kirveskari E. , Mäkelä J. P. , Shulga A.
Published: October 2019

Introduction

This case study explores the gains in hand function in an individual with a chronic spinal cord injury (SCI). The intervention was long-term paired associative simulation (PAS). We aimed to provide PAS until full recovery of hand muscle strength occurred, or until improvements ceased.

Case presentation

A 46-year-old man with traumatic C7 AIS B tetraplegia was administered PAS three times per week. After 24 weeks, PAS was combined with concomitant motor training of the remaining weak hand muscles. Outcome measures included the manual muscle test (MMT), motor-evoked potentials (MEPs), F-responses, hand functional tests, and the spinal cord independence measure (SCIM).

Discussion

After 47 weeks of PAS the subject had improved self-care and indoor mobility and was able to perform complex motor tasks (SCIM score improved from 40 to 56). His left hand regained maximum MMT score (total 75; increase of score from baseline condition 19); the effect remained stable in the 32-week follow up. In the right-hand muscles, MMT scores of 4–5 were observed in follow up (total 71; increase from baseline 48). Improved values were also observed in other outcomes. This is the first demonstration of long-term PAS restoring muscle strength corresponding to MMT scores of 4–5 in an individual with chronic SCI. The effect persisted for several months, indicating that PAS induces stable plastic changes in the corticospinal pathway.
Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix
Authors: Zhang Wenlong , Liu Ling , Su HuiFang , Liu Qin , Shen Jie , Dai Hanren , Zheng Wei , Lu Yan , Zhang Weijie , Bei Yuncheng , Shen Pingping
Published: October 2019

Background

The extracellular matrix (ECM) is essential for malignant tumour progression, as it is a physical barrier to various kinds of anticancer therapies. Matrix metalloproteinase (MMPs) can degrade almost all ECM components, and macrophages are an important source of MMPs. Studies using macrophages to treat tumours have shown that macrophages can enter tumour tissue to play a regulatory role.

Methods

We modified macrophages with a designed chimeric antigen receptor (CAR), which could be activated after recognition of the tumour antigen HER2 to trigger the internal signalling of CD147 and increase the expression of MMPs.

Results

Although CAR-147 macrophage treatment did not affect tumour cell growth in vitro compared with control treatment. However, we found that the infusion of CAR-147 macrophages significantly inhibited HER2-4T1 tumour growth in BALB/c mice. Further investigation showed that CAR-147 macrophages could reduce tumour collagen deposition and promote T-cell infiltration into tumours, which were consistent with expectations. Interestingly, the levels of the inflammatory cytokines TNF-α and IL-6, which are key factors in cytokine release syndrome, were significantly decreased in the peripheral blood in CAR-147 macrophage-transfused mice.

Conclusion

Our data suggest that targeting the ECM by engineered macrophages would be an effective treatment strategy for solid tumours.
Highly CO2-permeable membranes derived from a midblock-sulfonated multiblock polymer after submersion in water
Authors: Dai Zhongde , Deng Jing , Aboukeila Hesham , Yan Jiaqi , Ansaloni Luca , Mineart Kenneth P. , Giacinti Baschetti Marco , Spontak Richard J. , Deng Liyuan
Published: October 2019

To mitigate the effect of atmospheric CO2 on global climate change, gas separation materials that simultaneously exhibit high CO2 permeability and selectivity in gas mixtures must be developed. In this study, CO2 transport through midblock-sulfonated block polymer membranes prepared from four different solvents is investigated. The results presented here establish that membrane morphology and accompanying gas transport properties are sensitive to casting solvent and relative humidity. We likewise report an intriguing observation: submersion of these thermoplastic elastomeric membranes in liquid water, followed by drying prior to analysis, promotes not only a substantial change in membrane morphology, but also a significant improvement in both CO2 permeability and CO2/N2 selectivity. Measured CO2 permeability and CO2/N2 selectivity values of 482 Barrer and 57, respectively, surpass the Robeson upper bound, indicating that these nanostructured membranes constitute promising candidates for gas separation technologies aimed at CO2 capture.
Integrated analysis of transcriptomic and proteomic data from tree peony (P. ostii) seeds reveals key developmental stages and candidate genes related to oil biosynthesis and fatty acid metabolism
Authors: Wang Xiaojing , Liang Haiying , Guo Dalong , Guo Lili , Duan Xiangguang , Jia Qishi , Hou Xiaogai
Published: October 2019

Tree peony (Paeonia section Moutan DC.) seeds are an excellent source of beneficial natural compounds that promote health, and they contain high levels of alpha-linolenic acid (ALA). In recent years, tree peony has been emerging as an oil crop. Therefore, combined analysis of the transcriptome and proteome of tree peony (P. ostii) seeds at 25, 32, 39, 53, 67, 81, 88, 95, and 109 days after pollination (DAP) was conducted to better understand the transcriptional and translational regulation of seed development and oil biosynthesis. A total of 38,482 unigenes and 2841 proteins were identified. A total of 26,912 differentially expressed genes (DEGs) and 592 differentially expressed proteins (DEPs) were clustered into three groups corresponding to the rapid growth, seed inclusion enrichment and conversion, and late dehydration and mature stages of seed development. Fifteen lipid metabolism pathways were identified at both the transcriptome and proteome levels. Pathway enrichment analysis revealed that a period of rapid fatty acid biosynthesis occurred at 53–88 DAP. Furthermore, 211 genes and 35 proteins associated with the fatty acid metabolism pathway, 63 genes and 11 proteins associated with the biosynthesis of unsaturated fatty acids (UFAs), and 115 genes and 24 proteins associated with ALA metabolism were identified. Phylogenetic analysis revealed that 16 putative fatty acid desaturase (FAD)-encoding genes clustered into four FAD groups, eight of which exhibited the highest expression at 53 DAP, suggesting that they play an important role in ALA accumulation. RT-qPCR analysis indicated that the temporal expression patterns of oil biosynthesis genes were largely similar to the RNA-seq results. The expression patterns of fatty acid metabolism- and seed development-related proteins determined by MRM were also highly consistent with the results obtained in the proteomic analysis. Correlation analysis indicated significant differences in the number and abundance of DEGs and DEPs but a high level of consistency in expression patterns and metabolic pathways. The results of the present study represent the first combined transcriptomic and proteomic analysis of tree peony seeds and provide insight into tree peony seed development and oil accumulation.
Interpretable deep learning for guided microstructure-property explorations in photovoltaics
Authors: Pokuri Balaji Sesha Sarath , Ghosal Sambuddha , Kokate Apurva , Sarkar Soumik , Ganapathysubramanian Baskar
Published: October 2019

The microstructure determines the photovoltaic performance of a thin film organic semiconductor film. The relationship between microstructure and performance is usually highly non-linear and expensive to evaluate, thus making microstructure optimization challenging. Here, we show a data-driven approach for mapping the microstructure to photovoltaic performance using deep convolutional neural networks. We characterize this approach in terms of two critical metrics, its generalizability (has it learnt a reasonable map?), and its intepretability (can it produce meaningful microstructure characteristics that influence its prediction?). A surrogate model that exhibits these two features of generalizability and intepretability is particularly useful for subsequent design exploration. We illustrate this by using the surrogate model for both manual exploration (that verifies known domain insight) as well as automated microstructure optimization. We envision such approaches to be widely applicable to a wide variety of microstructure-sensitive design problems.
Biological and antibacterial properties of the micro-nanostructured hydroxyapatite/chitosan coating on titanium
Authors: Li Baoe , Xia Xiaomei , Guo Miaoqi , Jiang Yu , Li Yu , Zhang Zhiyuan , Liu Shimin , Li Haipeng , Liang Chunyong , Wang Hongshui
Published: October 2019

Titanium (Ti) is the widely used implant material in clinic, however, failures still frequently occur due to its bioinertness and poor antibacterial property. To improve the biological and antibacterial properties of Ti implants, micro-nanostructured hydroxyapatite (HA) coating was prepared on Ti surface by micro-arc oxidation (MAO), and then the antibacterial agent of chitosan (CS) was loaded on the HA surface through dip-coating method. The results showed that the obtained HA/CS composite coating accelerated the formation of apatite layer in SBF solution, enhanced cell adhesion, spreading and proliferation, and it also inhibited the bacterial growth, showing improved biological and antibacterial properties. Although, with the increased CS amount, the coverage of HA coating would be enlarged, resulting in depressed biological property, however, the antibacterial property of the composite coating was enhanced, and the cytotoxicity about CS was not detected in this work. In conclusion, the HA/CS coating has promising application in orthopedics, dentistry and other biomedical devices.
Unbalanced Expression of ICOS and PD-1 in Patients with Neuromyelitis Optica Spectrum Disorder
Authors: Xue Qun , Li Xiaoping , Gu Yanzheng , Wang Xiaozhu , Wang Mingyuan , Tian Jingluan , Duan Xiaoyu , Gao Hanqing , Ji Xiaopei , Yan Xiaoming , Dong Wanli , Fang Qi , Zhang Xueguang
Published: October 2019

Neuromyelitis optica spectrum disorder (NMOSD) likely results from humoral immune abnormalities. The role that helper T cells play in the pathogenesis of this disease is not fully understood. To ascertain the clinical significance of two important costimulatory molecules required for T-cell activation in the peripheral blood of patients with NMOSD, we examined the expression levels of a membrane- and soluble-type inducible costimulatory molecule (ICOS), its ligand (ICOSL), programmed death-1 (PD-1), and its ligand (PD-L1) in the peripheral blood of 30 patients with NMOSD and compared these levels with those in patients with longitudinally extensive transverse myelitis (LETM), those with optic neuritis (ON), and healthy controls (HCs). Our results showed that the ICOS/ICOSL and PD-1/PD-L1 pathways may play important roles in the early stages of NMOSD pathogenesis. ICOS and PD-1 are potential therapeutic targets and valuable biomarkers for the differential diagnosis of early-stage NMOSD.
Paradoxical epigenetic regulation of XAF1 mediates plasticity towards adaptive resistance evolution in MGMT-methylated glioblastoma
Authors: Wu Qiong , Berglund Anders E. , Wang Dapeng , MacAulay Robert J. , Mulé James J. , Etame Arnold B.
Published: October 2019

Epigenetic regulation of O6-alkylguanine DNA alkyltransferase (MGMT) is surrogate of intrinsic resistance to temozolomide (TMZ). However, mechanisms associated with adaptive resistance evolution of glioblastoma (GBM) relative to MGMT methylation remain unclear. We hereby report a paradoxical yet translational epigenetic regulation of plasticity towards adaptive resistance in GBM. Based on an adaptive resistance model of GBM cells with differential MGMT methylation profiles, MGMT-hypermethylation enhanced genetic and phenotypic plasticity towards adaptive resistance to TMZ while MGMT hypomethylation limited plasticity. The resulting model-associated adaptive resistance gene signature negatively correlated with GBM patient survival. XAF1, a tumor suppressor protein, paradoxically emerged as a mediator of differential plasticities towards adaptive resistance to TMZ through epigenetic regulation. XAF1 promoted resistance both in-vitro and in-vivo. Furthermore, XAF1 expression negatively correlated with XAF1 promoter methylation status, and negatively correlate with GBM patient survival. Collectively, XAF1 appears to have a pradoxical yet translational role in GBM.