bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors associated with implementation of a school-based comprehensive program for students with autism
Authors: Odom Samuel L , Sam Ann M , Tomaszewski Brianne
Published: January 2022

The purpose of this study was to examine influences on the implementation of a school-based comprehensive program for autistic children. Following the conceptual framework suggested by the Exploration, Preparation, Implementation, Sustainment (EPIS) model, variables from the outer context, inner context, and also that were part of the comprehensive program were explored. An index approach was employed for assessing implementation. The study was part of a larger cluster randomized control trial and took place in 39 elementary schools in a southeastern state within the United States. Variables associated with implementation were transformational leadership style of the principal, percentage of students in the school who were white, and adequacy of coaching. Implications for practice and future research were identified.

Lay abstract

The purpose of this study was to identify influences on the implementation of a school-based, comprehensive program for autistic students. Influences from the community context, from within the school organization, and from features of the intervention itself were examined. The study took place in 39 elementary schools in a southeastern state in the United States. Transformational leadership style of the building principal, percentage of white students at the school (which was proposed as a broader community socioeconomic variable), and adequacy of coaching were all associated with implementation.
The non-native phonetic perception mechanism utilized by bilinguals with different L2 proficiency levels
Authors: Liang Lijuan , Chen Baoguo
Published: January 2022

Aims:

The present study investigated whether bilinguals differing in L2 proficiency are different in their non-native phonetic perception mechanism.

Methodology:

An event-related potential (ERP) experiment was conducted, in which high and low L2 proficiency bilinguals were asked to focus their attention on a muted film while listening pre-attentively to phoneme contrasts arranged in the Oddball paradigm. Non-native and native phonetic conditions were investigated in two separate blocks.

Data and analysis:

The mean amplitudes of the ERP epochs time-locked to the onset of phonemes were analyzed within four consecutive time windows: 50–150 ms, 150–250 ms, 250–350 ms, and 350–600 ms. Repeated measures analyses were performed on the following factors: phonetic condition (non-native vs. native) × deviancy (standard vs. deviant) × brain region (frontal vs. parietal) × proficiency (high vs. low). Phonetic condition, deviancy, and brain region were within-subjects factors, whereas proficiency was a between-subjects factor.

Findings:

In the non-native phonetic condition, a deviancy effect in the form of mismatch negativity (MMN) and late discriminative negativity (LDN) ERP components was observed in bilinguals with high L2 proficiency, whereas the P3b and late positive component (LPC) were found in those with low L2 proficiency. In the native phonetic condition, the two proficiency groups were the same in the deviancy effect as manifested by their similar brain responses in the form of the MMN component.

Originality:

This was the first study to take native phonetic condition into consideration while investigating the relationship between L2 proficiency and non-native phonetic discrimination.

Significance/implications:

The current findings suggest that high L2 proficiency might be related to faster involuntary phonetic discrimination and efficient high-level phonetic evaluation, whereas low L2 proficiency bilinguals may need to rely on additional memory processing. Findings of this study provide more evidence for the perceptual plasticity in pre-attentive non-native phonetic processing as a function of L2 proficiency.
Forever wars: Divided government and the termination of interventions in support of civil war governments
Authors: Linebarger Christopher , Enterline Andrew J
Published: January 2022

Why do third-party states continue interventions in support of governments fighting civil wars even when continuing to do so appears futile from a military standpoint? To answer this question, we focus on third-party state domestic politics, theorising that institutional characteristics condition the likelihood that the third party will terminate support to a civil war government before a conflict ends. When a third-party state’s legislature and executive branches are controlled by opposing political parties, the third party’s executive is more likely to remain committed to an intervention in order to deny political opponents the opportunity to seize on the withdrawal as a basis for political advantage. To test this expectation, we assemble a data sample of third-party interventions in support of civil war governments during the period 1975–2009. The analysis suggests that the third-party divided government reduces the likelihood of an early termination of its support for a civil war government. Our analysis underscores the role of third-party domestic politics in understanding the dynamics of internationalised civil conflicts.
Using Community–Academic Partnerships and a Creative Expression Contest to Engage Youth in the Development of Communication Materials for Promoting Behaviors That Prevent COVID-19
Authors: Szeszulski Jacob , Helal Salsa Ghadir , Cuccaro Paula , Markham Christine M. , Martin Mary , Savas Lara S. , Valerio-Shewmaker Melissa , Walker Timothy J. , Springer Andrew E.
Published: January 2022

Youth can transmit COVID-19 to adults, but few communication materials exist for engaging youth in COVID-19 prevention behaviors. We describe the process of leveraging a community–academic partnership in a rapid response initiative to engage youth in a contest (i.e., Youth-Led Creative Expression Contest to Prevent COVID-19 across Texas) to develop creative public health messaging centered on the prevention of COVID-19 transmission and infection for their peers. Core activities included developing a request for applications that solicited submission of creative expression materials promoting the use of COVID-19 prevention behaviors (mask-wearing, social distancing, handwashing, not touching the face) from Texas youth in elementary, middle, and/or high school; sending the request for applications to 48 organizations in Austin, Brownsville, Dallas, El Paso, Houston, and San Antonio in summer 2020; and recruiting a youth advisory board to score submissions and award prizes. We report on youth engagement in the COVID communication contest across Texas and use statistics (chi-square and t-tests) to characterize and compare youth participants and their creative expression artwork. The contest resulted in 3,003 website views and 34 submissions eligible for scoring. Each submission averaged >2 prevention behaviors. On average, winning submissions included a higher number of prevention behaviors than nonwinning submissions. The prevention behavior “not touching the face” was included more often in winning submissions than nonwinning submissions. Elementary school children were less likely to include a mask in their submission compared with older youth. Existing community–academic networks can engage youth in the development of geographically and age-tailored communication materials.
Early Neuroprognostication Using Frontal Spectrograms in Moderately Sedated Cardiac Arrest Patients
Authors: Lee Jae Hoon
Published: January 2022

Introduction. The integrated suppression ratio throughout all electroencephalography (EEG) patterns has rarely been studied. The aim of this study was to evaluate the clinical utility of the suppression ratio and hyperactivity of EEG on spectrograms. Methods. This prospective observational study included 73 cardiac arrest patients. Hardwired frontal EEG monitoring with spectrograms (color density spectral arrays, CDSA) was used to predict neurological outcomes. The mean suppression ratio (MSR) and hyperactivity in the high-frequency band (HHF) in the spectrogram were investigated in moderately sedated patients. Sedative doses were considered to estimate the MSR, which was automatically measured. Results. Using propofol 30 to 40 µg/kg/min and remifentanil 0.1 to 0.15 µg/kg/min, all the patients with an MSR >30% died. At day 2, the MSR in patients with a good outcome was 0%. The cut off values were different as an MSR >30% at day 1 (AUC 0.815) and an MSR >1% at day 2 (AUC 0.891). Of the patients with an MSR ≤30%, HHF was the greatest predictor of a poor outcome (OR 12.858, P = .006). The best predictors of a poor outcome using the spectrogram were suppression ratio (SR) >30% or HHF at day 1 (AUC 0.88) and SR >1% or HHF at day 2 (AUC 0.909). Conclusions. The use of MSR and HHF in frontal spectrograms is convenient and may be successfully employed for early neuroprognostication in moderately sedated cardiac arrest patients. However, spectrograms should be used with electroencephalogram considering the effects of sedatives because of the imperfect detection of electrographic seizures and artifacts.
Conventional Versus Minimally Invasive Aortic Valve Replacement Surgery: A Systematic Review, Meta-Analysis, and Meta-Regression
Authors: Almeida Adriana Silveira , Ceron Rafael Oliveira , Anschau Fernando , de Oliveira Jeffchandler Belém , Leão Neto Tércio Campos , Rode Juarez , Rey Rafael Antonio Widholzer , Lira Kathize Betti , Delvaux Renan Senandes , de Souza Rodrigo Oliveira Rosa Ribeiro
Published: January 2022

Objective: To assess the potential benefits of minimally invasive aortic valve replacement (MIAVR) compared with conventional AVR (CAVR) by examining short-term outcomes. Methods: A systematic search identified randomized trials comparing MIAVR with CAVR. To assess study limitations and quality of evidence, we used the Cochrane Risk of Bias tool and GRADE and performed random-effects meta-analysis. We used meta-regression and sensitivity analysis to explore reasons for diversity. Results: Thirteen studies (1,303 patients) were included. For the comparison of MIAVR and CAVR, the risk of bias was judged low or unclear and the quality of evidence ranged from very low to moderate. No significant difference was observed in mortality, stroke, acute kidney failure, infectious outcomes, cardiac events, intubation time, intensive care unit stay, reoperation for bleeding, and blood transfusions. Blood loss (mean difference [MD] = −130.58 mL, 95% confidence interval [CI] = −216.34 to −44.82, I2 = 89%) and hospital stay (MD = −0.93 days, 95% CI = −1.62 to −0.23, I2 = 81%) were lower with MIAVR. There were shorter aortic cross-clamp (MD = 5.99 min, 95% CI = 0.99 to 10.98, I2 = 93%) and cardiopulmonary bypass (CPB) times (MD = 7.75 min, 95% CI = 0.27 to 15.24, I2 = 94%) in the CAVR group. In meta-regression analysis, we found that age was the variable with the greatest influence on heterogeneity. Conclusions: MIAVR seems to be an excellent alternative to CAVR, reducing hospital stay and incidence of hemorrhagic events. Despite significantly greater aortic cross-clamp and CPB times with MIAVR, this did not translate into adverse effects, with no changes in the results found with CAVR.
Potential Role for Non-Salvage Procedures in the Treatment of Kienböck Disease Stage IV: A Systematic Review
Authors: Wang Patrick Qi , Charron Brynn P. , Chan Kevin T. K. , Grewal Ruby , Suh Nina
Published: January 2022

Background:

The purpose of this systematic review is to identify whether non-salvage procedures can provide satisfactory and acceptable outcomes in Lichtman stage IV disease.

Methods:

The MEDLINE, Embase, and Cochrane databases were systematically searched for English publications between 1989 and 2019 that reported stage IV-specific primary treatment outcomes. Revisions and skeletally immature patients were excluded. Data extracted were patient demographics, pain scores, range of motion (ROM), grip strength, and patient-reported outcome measures (PROMs). The results were pooled into 3 categories: conservative management, non-salvage, and salvage procedures.

Results:

Data from 24 studies (n = 114 patients) were extracted. Compared with conservative management and non-salvage treatment (joint-leveling radial osteotomies, lunate reconstruction), salvage procedures (intercarpal and radiocarpal arthrodesis, proximal row carpectomy, total wrist arthroplasty) showed significantly decreased ROM in flexion-extension arc of motion (89° vs 95° vs 73°, respectively, P = .0001) and no significant differences in grip strength as a percentage of the contralateral side (83% vs 86% vs 79%, respectively, P = .28). All reported treatments provided pain relief, ability to return to previous occupations, and variable PROMs.

Conclusions:

In young, active, and labor-intensive patients, motion-preserving, non-salvage options may be worth trialing as they do not preclude future salvage options.
Mesoporous SBA-15 Silica–Loaded Nano-formulation of Quercetin: A Probable Radio-Sensitizer for Lung Carcinoma
Authors: Alkahtani Saad , Alarifi Saud , Aljarba Nada H. , Alghamdi Hamzah A. , Alkahtane Abdullah A.
Published: January 2022

Lung cancer is considered as one of the most serious disease worldwide. The progress of drug carriers based on nonmaterial, which selectively hold chemotherapeutic agents to cancer cells, has become a major focus in biomedical research. This study aimed to evaluate the growth inhibition and apoptosis induction of the human lung cancer cells (A-549) by Q-loaded SBA-15 conjugate system. Mesoporous silica nanoparticles (SBA-15) as host materials for transporting therapeutics medicaments were fabricated for targeted drug delivery toward lung cancer. With the objective of increasing bioavailability and aqueous solubility of flavonoids, SBA-15 was successfully loaded with the quercetin (Q)—a major flavonoid and characterized with the help of Fourier-transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). The biological investigation on A549 cell line confirmed that the efficacy of Q-SBA-15 is much higher than only Q. Moreover, the apoptotic pathway of synthesized Q-SBA-15 NPs examined that the Q-SBA-15–mediated apoptosis via PI3K/AKT/mTOR signaling pathway. Thus, the newly conjugated Q-SBA-15 system improved the apoptotic fate through caspase-mediated apoptosis via PI3K/AKT/mTOR signaling pathway and hence, it can be potentially employed as an anticancer agent for lung cancer.
A novel method for the evaluation of ejector based on a virtual nozzle and two indexes
Authors: Zheng Chaoyu , Chen Wu , Zheng Qingrong
Published: January 2022

This paper presents a novel method for ejector evaluation by developing a virtual nozzle, which provides the ejector’s maximum ability to overcome its back pressure and the minimum constant cross-section area based on two newly-derived evaluation indexes. The method was developed based on the assumption that the total energy and the ratio of dynamic enthalpy to total energy before normal shock of the virtual nozzle are the same as those of the real ejector. Under the condition that the initial state of the virtual nozzle is the same as that of the primary fluid of the ejector, two evaluation indexes, which include the relative pressure ratio and the relative area ratio, were derived to indicate the extent to which the ability to overcome back pressure and area demand deviate from the benchmark obtained from the virtual nozzle. Using the new method, the case studies of ejector evaluation were carried out involving with theoretical data of 13 refrigerants selected as working fluid of ejector and experimental data of four refrigerants. And the relationship between the two indexes was expressed by a high-accuracy fitting correlation equation that was validated by both theoretical calculation and experimental data and was found meaningful.
Kinematic analysis of seven-degree-of-freedom exoskeleton rehabilitation manipulator
Authors: Tang Gang , Sheng Jinqin , Wu Chuan , Wang Dongmei , Men Shaoyang
Published: January 2022

This article analyzes the forward kinematics and inverse kinematics of the seven-degree-of-freedom exoskeleton rehabilitation manipulator. Denavit–Hartenberg coordinates are used to model the forward kinematics, and the working space of the end effector of the manipulator is analyzed according to the joint motion range of the human arm. In the inverse solution of the seven-degree-of-freedom exoskeleton rehabilitation manipulator, the self-motion angle [Formula: see text] of the elbow is used. The minimum energy standard is used to calculate the self-motion angle [Formula: see text]. The minimum energy mainly includes the gravitational potential energy of the upper limbs and the elastic potential energy stored in the muscles. Thus, the inverse solution formula of the seven-degree-of-freedom exoskeleton rehabilitation manipulator is derived. When calculating the angle [Formula: see text], an auxiliary parameter is introduced to solve the self-motion manifold of the manipulator. Finally, the theoretical derivation and verification of the forward and inverse kinematics are carried out in this article, and through analysis of the results, it is concluded that the inverse kinematics of this article has some limitations but the theory of inverse kinematics is feasible.
Trigeminal neuropathic pain causes changes in affective processing of pain in rats
Authors: Araya Erika I , Carvalho Eduardo C , Andreatini Roberto , Zamponi Gerald W , Chichorro Juliana G
Published: January 2022

Trigeminal neuropathic pain has been modeled in rodents through the constriction of the infraorbital nerve (CCI-ION). Sensory alterations, including spontaneous pain, and thermal and mechanical hyperalgesia are well characterized, but there is a notable lack of evidence about the affective pain component in this model. Evaluation of the emotional component of pain in rats has been proposed as a way to optimize potential translational value of non-clinical studies. In rats, 22 and 50 kHz ultrasonic vocalizations (USVs) are considered well-established measures of negative and positive emotional states, respectively. Thus, this study tested the hypothesis that trigeminal neuropathic pain would result, in addition to the sensory alterations, in a decrease of 50 kHz USV, which may be related to altered function of brain areas involved in emotional pain processing. CCI-ION surgery was performed on 60-day-old male Wistar rats. 15 days after surgery, von Frey filaments were applied to detect mechanical hyperalgesia, and USV was recorded. At the same timepoint, systemic treatment with d,l-amphetamine (1 mg/kg) allowed investigation of the involvement of the dopaminergic system in USV emission. Finally, brain tissue was collected to assess the change in tyrosine hydroxylase (TH) expression in the nucleus accumbens (NAc) and c-Fos expression in brain areas involved in emotional pain processing, including the prefrontal cortex (PFC), amygdala, and NAc. The results showed that CCI-ION rats presented mechanical hyperalgesia and a significant reduction of environmental-induced 50 kHz USV. Amphetamine caused a marked increase in 50 kHz USV emission in CCI-ION rats. In addition, TH expression was lower in constricted animals and c-Fos analysis revealed an increase in neuronal activation. Taken together, these data indicate that CCI-ION causes a reduction in the emission of environmental-induced appetitive calls concomitantly with facial mechanical hyperalgesia and that both changes may be related to a reduction in the mesolimbic dopaminergic activity.
Afro-Germans, multidirectional memory and French colonial aphasia: The legacy of the First World War in Galadio by Didier Daeninckx
Authors: Branach-Kallas Anna
Published: January 2022

This article offers an analysis of mnemonic traces in Galadio, Didier Daeninckx’s 2010 novel. I demonstrate that by fictionalizing the history of the persecution of Afro-Germans under National Socialism, the novel exposes antiblackness as a neglected phenomenon of the Third Reich. Synchronously, applying Michael Rothberg’s theoretical framework, the article discusses the dialogue between Jewish and Afro-German legacies of violence in the novel, as well as the intricate relation between colony, camp and what Paul Gilroy defines as camp mentality. Furthermore, I argue that Daeninckx engages with French colonial aphasia: in my interpretation, his oblique approach to the French imperial past conveys its simultaneous presence and absence, which is key to disabled memory. Finally, I focus on the ethics of commemoration in Galadio, which claims space for black soldiers in French collective memory of the two world wars, yet at the same time challenges imperial loyalties and homogeneous approaches to French national identity.
Wearable transcutaneous electrical nerve stimulation (actiTENS®) is effective and safe for the treatment of knee osteoarthritis pain: a randomized controlled trial versus weak opioids
Authors: Maheu Emmanuel , Soriot-Thomas Sandrine , Noel Eric , Ganry Hervé , Lespessailles Eric , Cortet Bernard
Published: January 2022

Introduction:

Despite their poor tolerance, especially in the elderly, weak opioids (WO) remain commonly prescribed for patients with knee osteoarthritis (KOA). We compared the efficacy and safety of a new wearable transcutaneous electrical nerve stimulation (W-TENS) device with WO for the treatment of moderate-to-severe, nociceptive KOA chronic pain.

Methods:

The study was a non-inferiority, multicentric, prospective, randomized, single-blind, controlled, 2-parallel groups Trial. A total of 110 patients with KOA were included (Kellgren-Lawrence radiographic grade ⩾2; American College of Rheumatology criteria), with chronic moderate-to-severe nociceptive pain (mean 8-day pain intensity (PI) ⩾ 4 on an 11-point numerical rating scale), in failure to non-opioid analgesics, including nonsteroidal anti-inflammatory drugs (NSAIDs). Patients with neuropathic pain were excluded. The co-primary endpoints were mean PI at 3 months (M3) and number of potentially treatment-related adverse events (TRAEs). Secondary outcomes included Western Ontario MAC Master University function subscale (range, 0–68), additional pain and quality of life measures, and responder rates.

Results:

The non-inferiority of W-TENS was demonstrated in both the per protocol (PP) and intent-to-treat (ITT) populations. At M3, PI in PP population was 3.87 (2.12) compared with 4.66 (2.37) [delta: −0.79 (0.44); 95% CI (−1.65, 0.08)] in W-TENS and WO groups, respectively. A planned superiority analysis showed a significant superiority of W-TENS over WO on PI at M3 ( p = 0.0124). The number of TRAEs was significantly lower in the W-TENS group ( n = 7) than in the WO group ( n = 36) ( p < 0.001). Other secondary outcomes also favored W-TENS.

Conclusion:

W-TENS was more effective and better tolerated than WO in the treatment of chronic nociceptive KOA pain and offers an interesting non-pharmacological analgesic alternative in the management of KOA. Trial Registration: ClinicalTrials.gov: NCT03902340
Based on minimal clinically important difference values, a moderate dose of tanezumab may be a better option for treating hip or knee osteoarthritis: a meta-analysis of randomized controlled trials
Authors: Zhao Di , Luo Ming-hui , Pan Jian-ke , Zeng Ling-feng , Liang Gui-hong , Han Yan-hong , Liu Jun , Yang Wei-yi
Published: January 2022

Background:

Tanezumab is a nerve growth factor monoclonal antibody that may regulate pain in hip or knee osteoarthritis (OA). This meta-analysis was performed to evaluate the efficacy and safety of low and moderate doses of tanezumab in treating hip or knee OA.

Methods:

PubMed, EMBASE, the Cochrane Library, and Web of Science were comprehensively searched for clinical trials published before 1 May 2021. Patients were assessed via efficacy and safety outcomes.

Results:

Twelve randomized controlled trials including 6022 patients were identified. Both low and moderate doses of tanezumab significantly improved efficacy outcomes. However, only the point estimates (mean difference, MD) of moderate-dose tanezumab significantly exceeded the minimal clinically important differences (MCIDs). There were no significant differences in the incidence of treatment-related adverse events (AEs), withdrawals due to AEs, serious AEs, and total joint replacement between the tanezumab and placebo groups, whereas the incidence of AEs was higher in the tanezumab group (relative risk, RR = 1.10; 95% confidence interval, 95% CI = 1.04–1.17). The incidence of rapidly progressive OA was significantly higher in the combined low- and moderate-dose tanezumab groups than in the placebo group (RR = 5.01; 95% CI = 1.17–21.33). Furthermore, both low and moderate doses of tanezumab significantly increased the incidence of abnormal peripheral sensation (RR = 1.99, 95% CI = 1.21–3.28; RR = 2.64, 95% CI = 1.91–3.67, respectively). Compared with nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids, tanezumab showed significantly improved efficacy outcomes ( p < 0.05). However, the point estimates (MD) of tanezumab were not greater than the MCID. Pooled analysis showed no significant differences between tanezumab and NSAIDs and opioids in safety outcomes ( p > 0.05).

Conclusion:

Tanezumab is efficacious in patients with hip or knee OA. Tanezumab is relatively well tolerated and safe but increases the incidence of AEs and reversible abnormal peripheral sensation. Additional studies on the occurrence of rapidly progressive OA are needed. A moderate dose of tanezumab may maximize the benefits for hip or knee OA.
Development of a Novel Insulin Sensor for Clinical Decision-Making
Authors: Vargas Eva , Aiello Eleonora M. , Pinsker Jordan E. , Teymourian Hazhir , Tehrani Farshad , Church Mei Mei , Laffel Lori M. , Doyle Francis J. , Patti Mary-Elizabeth , Dassau Eyal , Wang Joseph
Published: January 2022

Background:

Clinical decision support systems that incorporate information from frequent insulin measurements to enhance individualized diabetes management remain an unmet goal. The development of a disposable insulin strip for fast decentralized point-of-care detection replacing the current centralized lab-based methods used in clinical practice would be highly desirable to improve the establishment of individual insulin absorption patterns and algorithm modeling processes.

Methods:

We carried out the development and optimization of a novel decentralized disposable insulin electrochemical sensor focusing on obtaining high analytical and operational performance toward achieving a true point-of-care insulin testing device for clinical on-site application.

Results:

Our novel insulin immunosensor demonstrated an attractive performance and efficient user-friendly operation by providing high sensitivity capability to detect endogenous and analog insulin with a limit of detection of 30.2 pM (4.3 µiU/mL), rapid time-to-result, stability toward remote site application, and scalable low-cost fabrication with an estimated cost-of-goods for disposable consumables of below $5, capable of near real-time insulin detection in a microliter (≤10 µL) sample droplet of undiluted serum within 30 minutes.

Conclusions:

The results obtained in the optimization and characterization of our novel insulin sensor illustrate its suitability for its potential application in remote clinical environments for frequent insulin monitoring. Future work will test the insulin sensor in a clinical research setting to assess its efficacy in individuals with type 1 diabetes.
Naviculectomy With Limited Soft-Tissue Releases as a Third Way Beyond Manipulative Treatment and Extensive Soft-Tissue Releases for Ambulatory Children With Complex Congenital Vertical Talus: A Technical Note
Authors: Aly Ahmad S. , Samir Shady , Mahmoud Shady , El-Sobky Tamer A.
Published: January 2022

We investigated the radioclinical outcomes of naviculectomy and limited/tailored soft-tissue releases in a short series of ambulatory children with complex/intractable congenital vertical talus subsets namely neglected, multiple operated, and recurrent patients. We postulated that this technique will yield satisfactory radioclinical outcomes and minimal complications because it avoids extensive surgical release/trauma that is otherwise classically recommended for complex congenital vertical talus. The cohort consisted of 5—4 boys and 1 girl—complex congenital vertical talus children with neglected, multiple operated, and/or recurrent subsets. Patients were included if manipulative casting techniques were deemed unlikely to produce a plantigrade foot. Patients underwent naviculectomy with variable on-demand limited soft-tissue releases. Two patients had bilateral affection and 2 had a nonidiopathic cause. The mean age was 5.2 years (4-6.25) and mean follow-up was 2.3 years (1-3). We reported satisfactory outcomes as per foot posture, function, overall parent satisfaction including pain and radiography per lateral views of talar-axis-first metatarsal base angle on the short/intermediate term. Whereas manipulative casting is unlikely to yield lasting outcomes in ambulatory children with complex subsets of congenital vertical talus, extensive surgical soft-tissue releases have unfavorable long-term complications. As a substitute, naviculectomy as a form of resection arthroplasty created a practical and affordable third way between manipulative casting with or without minimally invasive surgery and the extensive surgical soft-tissue releases on the short-to-intermediate term.

Level of Evidence:

Level IV case series
Rethinking Audience Fragmentation Using a Theory of News Reading Publics: Online India as a Case Study
Authors: Mukerjee Subhayan
Published: January 2022

Scholarly work that seeks to theorize about fragmentation of media audiences has largely been restricted to the experiences of advanced democracies in the west. This has resulted in a preponderance of research endeavors that have sought to understand this phenomenon through ideas that are pertinent, perhaps solely to those contexts, and not as applicable outside, particularly in the Global South. This has potentially limited our imagination into various other ways in which audience fragmentation can manifest in these often-overlooked countries. In this paper, I use the case of online India as an example to offer a theoretical framework – that of news reading publics – for understanding audience fragmentation as a more global socio-political phenomenon that allows for rigorous comparative research, without being restrictive in scope. I draw from existing theories in communication and related disciplines and show how such a framework can be situated within existing social science theory. I argue that this framework should make us think of audience fragmentation in western contexts to be special cases of a more general model. I also show how network analysis can be used as a context-agnostic tool for identifying news reading publics and demonstrate the utility of such a method in complementing this theoretical framework. Finally, I discuss potential future research directions that this framework generates.
‘Doing Reggio?’ Exploring the complexity of ‘curriculum’ migration through a comparison of Reggio Emilia, Italy and the EYFS, England
Authors: Chicken Sarah
Published: January 2022

This paper begins a quarter of a century ago with the first visit to the UK of the Reggio Emilia exhibition ‘The Hundred Languages of Children’ and initial interest by some of the early education community in ‘doing Reggio’. Within the same period, the move to introduce a formal curriculum for young children in England and Wales began, initially with the Desirable Outcomes documents in 1996 (SCAA) and more recently with the latest incarnation of the Early Years Foundation Stage. This paper first explores key aspects of the Reggio Emilia approach before turning to the development of the curriculum for young children within England, making visible key differences between these two ways of working. Drawing on Foucauldian discourses, I aim to demonstrate that curricula models are underpinned by socially constructed discourses and that as the discourse of ‘school readiness’ has tightened its stranglehold on early years policy within England, the likelihood of ‘doing Reggio’ has been eroded significantly.
Uterus didelphys with double vagina diagnosed during third cesarean section: A case report
Authors: Dorji Namkha , Tshering Sangay , Wangden Tshering
Published: January 2022

Uterus didelphys is a rare uterine anomaly. It is associated with fetal breech presentation, preterm delivery, and cesarean section. Longitudinal vaginal septum may be associated with uterus didelphys, which may cause dyspareunia and labor obstruction. We report a case of 28-year-old woman whose uterus didelphys and longitudinal vaginal septum were diagnosed during third cesarean section. This case report highlights the importance of routine examination of adnexal structures during cesarean section, so that any unsuspected pathologies in the uterus, tubes, and ovaries are diagnosed.
Introduction: A Decade of Social Media Elections
Authors: Jensen Jakob Linaa , Schwartz Sander Andreas
Published: January 2022

Social media has been a part of election campaigns for more than a decade. In this special issue, we combine longitudinal and cross-national studies of social media in election campaigns, expanding the time span as well as number of countries compared to former comparative studies. The four papers present examples of longitudinal studies, covering multiple election cycles from four different countries: Australia, the United States of America, Denmark, and Italy. By including the countries mentioned, we focus on countries considered to be “first movers” when it comes to the digitization and internetization of the political life. As such, they are “most similar cases.” However, they also have different political systems: the United States and Australia are characterized by a Westminster system dominated by a few large parties and a tradition of strong confrontation between government and opposition, whereas Denmark and Italy are multi-party systems with a tradition of collaboration and coalition governments. Technologically, the four countries might be similar, but politically and in terms of media systems, they differ; the United States is characterized by a commercialized American media system with little role for public service broadcasters, Denmark has very strong public service media, and Australia has elements of both these systems. Finally, Italy represents a Southern European media system with traces of clientelism as well as public service media. Thus, studies of the four countries form a diverse yet solid set of cases for exploring the growing (and changing) role of social media in national elections.
Glucose-dependent insulinotropic polypeptide and tissue inflammation: Implications for atherogenic cardiovascular disease
Authors: He Xiaoming
Published: January 2022

Glucose-dependent insulinotropic polypeptide (GIP) has pleiotropic actions on pancreatic endocrine function, adipose tissue lipid metabolism, and skeletal calcium metabolism. Recent data indicate a potential new role for GIP in the pathogenesis of cardiovascular disease. This review focuses on the emerging literature that highlights GIP’s role in inflammation—an established process in the initiation and progression of atherosclerosis. In vasculature tissue, GIP may reduce concentrations of circulating inflammatory cytokines, attenuate vascular endothelial inflammation, and directly limit atherosclerotic vascular damage. Important to recognize is that evidence exists to support both pro- and anti-inflammatory effects of GIP even within the same tissue/cell type. Therefore, future study designs must account for factors such as model heterogeneity, physiological relevance of doses/exposures, potential indirect effects on inflammatory pathways, and the glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist form. Elucidating the specific effects of enhanced GIP signaling in vascular inflammation and atherosclerosis is crucial given the existing widespread use of DPP4 inhibitors and the emergence of dual-incretin receptor agonists for type 2 diabetes treatment.
Which Anxious Adolescents Were Most Affected by the COVID-19 Pandemic?
Authors: Morales Santiago , Zeytinoglu Selin , Lorenzo Nicole E. , Chronis-Tuscano Andrea , Degnan Kathryn A. , Almas Alisa N. , Pine Daniel S. , Fox Nathan A.
Published: January 2022

Although the COVID-19 pandemic caused significant stress and anxiety among many people, individuals’ experiences varied. We examined whether specific forms of anxiety predicted distinct trajectories of anxiety, perceived stress, and COVID-related worries during 3 early months of the pandemic. In a longitudinal study ( N = 291), adolescents’ ( n = 194) social anxiety and generalized anxiety levels were assessed via parent reports and self-reports and clinical diagnostic interviews. Later, when these adolescents were young adults ( n = 164), anxiety, stress, and COVID-related worries were assessed thrice during the pandemic. Prepandemic generalized anxiety predicted higher initial levels and maintenance of anxiety, stress, and COVID-related worries during the pandemic. In contrast, prepandemic social anxiety predicted lower initial levels of anxiety, stress, and COVID-related worries, but this initial effect on anxiety and stress was offset over time by social anxiety’s positive effect on the slope. Our results highlight the importance of understanding how prepandemic factors influence individuals’ experiences during the pandemic.
The Effect of COVID-19 Lockdowns on Maternal Mental Health and Parenting Practices Moderated by Urban Green Space
Authors: Narea Marigen , Asahi Kenzo , Abufhele Alejandra , Telias Amanda , Gildemeister Damián , Alarcón Samanta
Published: January 2022

Stress generates difficulties in parenting, which affects child development. We aimed to understand the impact of COVID-19 lockdowns on maternal mental health and parenting practices. We also explored to what extent green space is a protective factor in the aforementioned relationship. We explored heterogeneous lockdown effects using longitudinal georeferenced data for 985 families (mothers and 24- to 30-month-olds) and exploiting localized lockdowns in Chile. Controlling for observed and unobserved fixed characteristics, on average, we did not find an association between lockdown duration and maternal mental health or parenting practices. However, the previous nonsignificant association is heterogeneous across access to green space. Although lockdown duration increased dysfunctional interactions with children for mothers with little access to green space, we did not see the previous effect on mothers who live close to green space. Mothers who do not comply with the lockdown mandate are the ones who drive this heterogeneous effect.
The Turtle Neck Sign: Identification of Severe Retracted Distal Biceps Tendon Rupture
Authors: Boonrod Artit , Harasymczuk Michal , Ramazanian Taghi , Boonrod Arunnit , Smith Jay , O’Driscoll Shawn W.
Published: January 2022

Background:

Chronic tendon retraction subsequent to distal biceps tendon rupture significantly increases repair difficulty and potential for tendon grafting. Biceps tendons that appear short or absent with magnetic resonance imaging (MRI) or that cannot be readily identified at surgery may erroneously be classified as irreparable. These apparent “absent” biceps tendons may actually be retracted and curled up inside the muscle, visually resembling the head-neck of a turtle retracted inside its shell (the “turtle neck sign”). When located, these tendons could be unfolded and repaired primarily. This type of tendon retraction seems to be associated with high-degree ruptures and larcertus fibrosus tears.

Purpose:

To test the hypothesis that tendon retractions with a turtle neck sign on MRI are more associated with high-degree ruptures and larcertus fibrosus tears versus tendon tears with simple linear retraction.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

Retracted distal biceps tendon ruptures on sagittal MRI were categorized as linear retraction or curled-up (turtle neck) retraction. Retraction length, injury severity, and lacertus fibrosus tears were analyzed.

Results:

The authors retrospectively analyzed the patient records of 85 consecutive traumatic distal biceps tendon ruptures from 2003 to 2019; the final study cohort was 37 patients. Injury-to-surgery timing was as follows: <3 weeks, 43% (16 cases); 3 weeks to 3 months, 32% (12 cases); and >3 months, 24% (9 cases). Overall, 19 patients had linear retraction <7 cm (mean, 3.3 ± 1.9 cm) and 18 patients had a turtle neck retraction ≥7 cm (mean, 9.1 ± 1.6 cm). The injury-to-surgery time (median [± interquartile range]) was 27 days (±90 days) in the linear retraction group and 23 days (±65 days) in the turtle neck retraction group. The turtle neck retraction group had a significantly higher occurrence of abnormal hook test findings, complete distal biceps tendon rupture, and lacertus fibrosus tears compared with the linear retraction group (100% vs 58%, 100% vs 68%, and 100% vs 37%, respectively; P ≤ .02). However, significant repairability differences were not found.

Conclusion:

Highly retracted distal biceps turtle neck sign tendon ruptures occur frequently in association with high-degree ruptures and lacertus fibrosus tears. The presence of a turtle neck retraction did not affect reparability. Surgeons should be aware of this curled-up retraction to avoid mistaking it for an absent tendon or a muscle-tendon disruption.
Esophageal Intramural Pseudodiverticulosis and Esophagobronchial Fistula Palliated with Esophageal and Bronchial Stenting: A Rare Case Report
Authors: Nitz Jonathan A. , Mirza Mohammed H. , Whorf Daniel H. , Austin Brett , Anderson Richard C.
Published: January 2022

Esophageal intramural pseudodiverticulosis (EIP) is a rare condition characterized by outpouchings from the esophageal lumen into the outer esophageal wall. It can lead to complications such as esophageal strictures presenting as dysphagia and esophagobronchial fistula (EBF) presenting as recurrent aspiration pneumonia. Only 1 other report of EIP with EBF has been reported in the literature. EIP itself is typically managed medically while a complication such as EBF, on the other hand, elicits far more invasive approaches in the form of open surgical intervention. We present the case of a 50 year-old male newly diagnosed with EIP complicated by EBF who was palliated with esophageal stenting. Upper endoscopy with esophageal stent placement offers a safe, feasible, and non-operative therapy for EIP and EBF.
Medical Management of Obesity as it Affects Reflux
Authors: Haddad James D. , Shah Shawn L.
Published: January 2022

Gastroesophageal reflux disease (GERD) is common among the American population and increasing in prevalence, with obesity being implicated as one of the strongest risk factors for its development. Little is known about the effects of currently prescribed anti-obesity medications on GERD symptoms. This review aims to explore the current literature on FDA-approved and off-label anti-obesity pharmacotherapy with respect to their influence on GERD and interactions with commonly prescribed GERD medications.
Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker
Authors: Qiu Yingqi , Wang Hao , Liao Peiyun , Xu Binyan , Hu Rong , Yang Yulu , Li Yuhua
Published: January 2022

Background

Belonging to the protein arginine methyltransferase (PRMT) family, the enzyme encoded by coactivator associated arginine methyltransferase 1 (CARM1) catalyzes the methylation of protein arginine residues, especially acts on histones and other chromatin related proteins, which is essential in regulating gene expression. Beyond its well-established involvement in the regulation of transcription, recent studies have revealed a novel role of CARM1 in tumorigenesis and development, but there is still a lack of systematic understanding of CARM1 in human cancers. An integrated analysis of CARM1 in pan-cancer may contribute to further explore its prognostic value and potential immunological function in tumor therapy.

Results

Based on systematic analysis of data in multiple databases, we firstly verified that CARM1 is highly expressed in most tumors compared with corresponding normal tissues, and is bound up with poor prognosis in some tumors. Subsequently, relevance between CARM1 expression level and tumor immune microenvironment is analyzed from the perspectives of tumor mutation burden, microsatellite instability, mismatch repair genes, methyltransferases genes, immune checkpoint genes and immune cells infiltration, indicating a potential relationship between CARM1 expression and tumor microenvironment. A gene enrichment analysis followed shortly, which implied that the role of CARM1 in tumor pathogenesis may be related to transcriptional imbalance and viral carcinogenesis.

Conclusions

Our first comprehensive bioinformatics analysis provides a broad molecular perspective on the role of CARM1 in various tumors, highlights its value in clinical prognosis and potential association with tumor immune microenvironment, which may furnish an immune based antitumor strategy to provide a reference for more accurate and personalized immunotherapy in the future.
Genome-wide analysis reveals the spatiotemporal expression patterns of SOS3 genes in the maize B73 genome in response to salt stress
Authors: Cao Yunying , Shan Tingyu , Fang Hui , Sun Kangtai , Shi Wen , Tang Bei , Wu Junping , Wang Kai , Li Ping , Wang Baohua
Published: January 2022

Background

Salt damage is an important abiotic stress that affects the growth and yield of maize worldwide. As an important member of the salt overly sensitive (SOS) signal transduction pathway, the SOS3 gene family participates in the transmission of stress signals and plays a vital role in improving the salt tolerance of plants.

Results

In this study, we identified 59 SOS3 genes in the maize B73 genome using bioinformatics methods and genome-wide analyses. SOS3 proteins were divided into 5 different subfamilies according to the phylogenetic relationships. A close relationship between the phylogenetic classification and intron mode was observed, with most SOS3 genes in the same group sharing common motifs and similar exon-intron structures in the corresponding genes. These genes were unequally distributed on five chromosomes of B73. A total of six SOS3 genes were identified as repeated genes, and 12 pairs of genes were proven to be segmentally duplicated genes, indicating that gene duplication may play an important role in the expansion of the SOS3 gene family. The expression analysis of 10 genes that were randomly selected from different subgroups suggested that all 10 genes were significantly differentially expressed within 48 h after salt treatment, of which eight SOS3 genes showed a significant decline while Zm00001d025938 and Zm00001d049665 did not. By observing the subcellular localization results, we found that most genes were expressed in chloroplasts while some genes were expressed in the cell membrane and nucleus.

Conclusions

Our study provides valuable information for elucidating the evolutionary relationship and functional characteristics of the SOS3 gene family and lays the foundation for further study of the SOS3 gene family in the maize B73 genome.