bluuebunny/crossref_metadata_2025 huggingface dataset:
CONCEPTUALIZATION OF THE LOCAL SPACE OF KYIV IN THE LANGUAGE OF ARTISTIC PROSE OF THE 20TH CENTURY
Authors: Holikova Nataliia
Published: August 2023

The article examines the linguistic features of the conceptualization of the local space of the “Kyiv” mindset in the language of artistic prose by two outstanding Ukrainian writers of the 20th century. – V. Pidmohylnyi and P. Zahrebelnyi. Emphasis is placed on the fact that the local-spatial constant of the linguistic-cultural concept of the proper name “Kyiv”, reflected in the artistic discourses of artists, captures many urban and natural objects, which partially reflect the extremely complex topographical and coordinate grid of the real city. The system of urbanonyms, which represent the specifics of the individual and linguistic pictures of the world of novelists in terms of fixing the realities of the same city in different historical periods of its life, is studied. From the point of view of linguistic stylistics, a comparative analysis of expressive and figurative means of addressing the “Kyiv” mindset in the novel “The City” by V. Pidmohylnyi and in a number of historical novels and works about modernity by P. Zahrebelnyi was carried out. It is noted that the study of the verbalized constant of the local space of the city is an important issue not only for integrative linguistic stylistics, but also for cognitive linguistics, conceptology, linguistic and cultural studies, etc. The semantic-stylistic and logical-cognitive transformations of the internal forms of a number of proper names, which in P. Zahrebelnyi's artistic discourse have consistently evolved from an urbanonym to a concept have been traced. It was concluded that V. Pidmohylnyi, having “immersed” Stepan Radchenko, a rural man, in the urbanized space with its anthropogenic landscape, was one of the first Ukrainian writers of the beginning of the 20th century. conceptualized the city as a determining factor in the civilizational and historical development of society. In the artistic discourse of P. Zahrebelnyi, numerous linguistic units that nominate the real landscape of the city reflect the philosophy of the author's vision of Kyiv as a unique, originally Ukrainian city, as it appears in the national-linguistic picture of the world.
EMOTIONS IN THE PROCESS OF FORMING THE PROFESSIONAL COMMUNICATIVE COMPETENCE OF A PHILOLOGIST
Authors: Shulzhuk Natalii
Published: August 2023

The article characterizes the emotional dominant as a motivational basis of human cognitive and communicative activity and a powerful regulator of the formation of the pragmatics of speech. The focus of the linguistic description of emotions, focused primarily on elucidating the mechanism of realization of the emotional potential of language units and on the formation of emotional additions to their linguistic semantics in the context of a certain linguistic culture, enables the study of emotional meanings that a linguistic personality transmits through language, and the creation of an effective method of formation her emotional competence. Modern linguistic concept is focused in the problematic field of emotiology (linguistics of emotions), which studies the typology of emotional signs-fixators of various emotions and their national and cultural specificity presentations The pragmatics of description and expression of emotions, their concealment and imitation determined the place of the linguistics of emotions in the pragmalinguistic and communicative-activity paradigms. In this regard, the author substantiates the expediency of forming the professional communicative competence of a philologist on emotional and value bases and shares the reasoning of scientists regarding the definition of such basic criteria for the formation of emotional competence of a linguistic personality as the ability to generate emotionally correct texts and adequately perceive the personal emotional dominants of other people's texts as a reflection other conceptual spheres and cultures. In the context of the raised problem, the method of forming the professional communicative competence of a philologist on emotional and value bases, which orients him to emotionally healthy communicative interaction and harmonization of life activities, becomes relevant. Having analyzed the content of textbooks, training manuals and collections of exercises and tasks from traditional linguistic disciplines for students of higher education in philological specialties of higher education institutions, the author came to the conclusion that language is represented in them primarily as a semiotic system. Therefore, the article presents considerations regarding the place of emotiology in the professional formation of a philologist. The author emphasizes the practical value of the linguistic and cultural approach to the study of emotions.
Pengukuran Budaya Keselamatan Pasien di Pelayanan Kesehatan Primer: Literature Review
Authors: Mutia Davina , Dhamanti Inge
Published: August 2023

Pendahuluan: Penelitian keselamatan pasien sering kali berfokus di rumah sakit, faktanya insiden keselamatan pasien di pelayanan kesehatan primer sering terjadi. Insiden keselamatan pasien di pelayanan kesehatan primer salah satunya disebabkan oleh penerapan budaya keselamatan pasien yang belum diterapkan secara luas. Pengukuran budaya keselamatan pasien di pelayanan kesehatan primer dapat meningkatkan keselamatan pasien dan menurunkan angka insiden keselamatan pasien. Tujuan: Mengidentifikasi dimensi budaya keselamatan pasien dengan skor rendah dan membutuhkan peningkatan. Metode: Pencarian artikel dilakukan melalui database PubMed dan ScienceDirect menggunakan kata kunci “patient safety” AND “safety culture” AND “primary care”. Dari total 199 artikel yang ditemukan, hanya 10 artikel yang memenuhi kriteria inklusi. Hasil: Instrumen SAQ-AV, MOSPSC, dan HSOPSC merupakan instrumen pengukuran budaya keselamatan pasien yang digunakan pada 242 pelayanan kesehatan primer di 8 negara. Berdasarkan penelitian, setiap pelayanan kesehatan primer memiliki dimensi budaya keselamatan pasien yang perlu peningkatan. Dimensi kondisi kerja, tekanan kerja dan kecepatan, dan dimensi respon tidak menghukum terhadap keselahan merupakan dimensi yang paling sering membutuhkan peningkatan. Simpulan: Dimensi persepsi manajemen, kondisi kerja, kepuasan kerja, tekanan kerja dan kecepatan, dukungan kepemimpinan, frekuensi pelaporan insiden, kepegawaian, respon tidak menyalahkan, handsoff dan tansisi, memiliki nilai rendah dan membutuhkan peningkatan dalam penerapan budaya keselamatan pasien.
Structural patterns enhancing the antibacterial activity of metallacarborane-based antibiotics
Authors: Cebula Jakub , Fink Krzysztof , Goldeman Waldemar , Szermer-Olearnik Bożena , Nasulewicz-Goldeman Anna , Psurski Mateusz , Cuprych Monika , Kędziora Anna , Dudek Bartłomiej , Bugla-Płoskońska Gabriela , Chaszczewska-Markowska Monika , Gos Michalina , Migdał Paweł , Goszczyński Tomasz M.
Published: August 2023

Healthcare systems heavily rely on antibiotics to treat bacterial infections but widespread of the multidrug-resistant bacteria puts this strategy in danger. Novel drugs capable of overcoming current resistances are needed if our ability to treat bacterial infections is to be maintained. Boron clusters offer a valuable possibility to create a new class of antibiotics and expand antibiotic’s chemical space beyond conventional carbon-based molecules. In this work, we identified the two promising structural patterns providing cobalta bis(dicarbollide)(COSAN)-based compounds with potent and selective activity toward Staphylococcus aureus (including clinical strains): introduction of the α-amino acid amide and addition of iodine directly to the metallacarborane cage. Furthermore, we found that proper hydrophilic-lipophilic balance is crucial for the selective activity of the tested compounds toward S. aureus over mammalian cells. The patterns proposed in this paper can be useful in the development of metallacarborane-based antibiotics with potent antibacterial properties and low cytotoxicity.
Electrochemical Generation of High-Valent Oxo-Manganese Complexes Featuring an Anionic N5 Ligand and Their Role in O―O Bond Formation
Authors: Biswas Sachidulal , Chowdhury Srijan Narayan , Lepcha Panjo , Sutradhar Subhankar , Das Abhishek , Paine Tapan Kanti , Paul Satadal , Biswas Achintesh N
Published: August 2023

Generation of high-valent oxomanganese complexes through controlled removal of protons and electrons from low-valent congeners is a crucial step toward the synthesis of functional analogues of the native oxygen evolving complex (OEC). In-depth studies of the water oxidation activity of such biomimetic compounds help to understand the mechanism of O―O bond formation presumably occurring at the last step of the photosynthetic cycle. Scarce reports of reactive high-valent oxomanganese complexes underscores the impetus for the present work, wherein we report the electrochemical generation of the non-heme oxomanganese(IV) species, [(dpaq)MnIV(O)]+ (2), through a proton-coupled electron transfer (PCET) process from the hydroxomanganese complex [(dpaq)MnIII(OH)]ClO4 (1). Controlled potential spectroelectrochemical studies of 1 in wet acetonitrile at 1.45 V vs. NHE revealed quantitative formation of 2 within 10 min. The high-valent oxomanganese(IV) transient exhibited remarkable stability and could be reverted to the starting complex (1) by switching the potential to 0.25 V vs. NHE. The formation of 2 via PCET oxidation of 1 demonstrates an alternate pathway for the generation of the oxomanganese(IV) transient (2) without the requirement of redox-inactive metal ions or acid additives as proposed earlier. Theoretical studies predict that one-electron oxidation of [(dpaq)MnIV(O)]+ (2) forms a manganese(V)-oxo (3) species, which can be oxidized further by one-electron to a formally manganese(VI)-oxo transient (4). Theoretical analyses suggest that the first oxidation event (2 to 3) takes place at the metal-based d-orbital whereas, in the second oxidation process (3 to 4), the electron eliminates from an orbital composed of equitable contribution from metal and ligand, leaving a single electron in the quinoline-dominated orbital in the doublet ground spin state of the manganese(VI)-oxo species (4). This mixed metal- ligand (quinoline)-based oxidation is proposed to generate a formally Mn(VI) species (4), a non-heme analogue of the species ‘compound I’, formed in the catalytic cycle of cytochrome P-450. We propose that the highly electrophilic species 4 catches water during cyclic voltammetry experiments and results in O―O bond formation leading to electrocatalytic oxidation of water to hydrogen peroxide.
Unraveling the Bürgi-Dunitz Angle with Precision: The Power of a Two-Dimensional Energy Decomposition Analysis
Authors: Fernández Israel , Bickelhaupt F. Matthias , Svatunek Dennis
Published: August 2023

Understanding the geometrical preferences in chemical reactions is crucial for advancing the field of organic chemistry and improving synthetic strategies. One such preference, the Bürgi-Dunitz angle, is central to nucleophilic addition reactions involving carbonyl groups. This study successfully employs a novel two-dimensional Distortion-Interaction/Activation-Strain Model in combination with a two-dimensional Energy Decomposition Analysis to investigate the origins of the Bürgi-Dunitz angle in the addition reaction of CN– to (CH3)2C=O. We constructed a 2D potential energy surface defined by the distance between the nucleophile and carbonylic carbon atom and by the attack angle, followed by an in-depth exploration of energy components including strain and interaction energy. Our analysis reveals that the Bürgi-Dunitz angle emerges from a delicate balance between two key factors: strain energy and interaction energy. High strain energy, as a result of the carbonyl compound distorting to avoid Pauli repulsion, is encountered at high angles, thus setting the upper bound. On the other hand, interaction energy is shaped by a dominant Pauli repulsion when the angles are lower. This work emphasizes the value of the 2D Energy Decomposition Analysis as a refined tool, offering both quantitative and qualitative insights into chemical reactivity and selectivity.
Assessment of DLPNO-MP2 Approximations in Double-Hybrid DFT
Authors: Neugebauer Hagen , Pinski Peter , Grimme Stefan , Neese Frank , Bursch Markus
Published: August 2023

The unfavorable scaling (N5) of conventional second-order Møller-Plesset theory (MP2) typically prevents the application of double-hybrid (DH) density functionals to large systems with more than 100 atoms. A prominent approach to reduce the computational demand of electron correlation methods is the domain-based local pair natural orbital (DLPNO) approximation that is successfully used in the framework of DLPNO-CCSD(T). Its extension to MP2 [P. Pinski, C. Riplinger, E. F. Valeev and F. Neese, J. Chem. Phys. 143, 034108 (2015)] paved the way for DLPNO-MP2-based double-hybrid methods. In this work, we assess the accuracy of the DLPNO-MP2 approximation compared to conventional double-hybrids on a large number of 7925 data points for thermochemistry and 239 data points for structural features, including main-group and transition-metal systems. It is shown that DLPNO-DH-DFT can be applied successfully to perform energy calculations and geometry optimizations for large molecules at a drastically reduced computational cost. Furthermore, PNO space extrapolation is shown to be applicable, similar to its DLPNO-CCSD(T) counterpart, to reduce the remaining error.
Real-time monitoring of cell adhesion on to a soft substrate by a graphene impedance biosensor
Authors: Guglielmotti Victoria , Fuhry Emil , Neubert Tilmann J , Kuhl Michel , Pallarola Diego , Balasubramanian Kannan
Published: August 2023

Soft substrates are interesting for a range of applications from mimicking cellular micro-environment to implants. Conductive electrodes on soft substrates open a broad spectrum of possibilities such as electrical and electrochemical sensing coupled with the flexibility, elasticity and transparency of the underlying substrate. Single layer graphene on a soft substrate as a candidate for such flexible electrodes brings the additional advantage that the active area of the sensor is transparent and conformal to the underlying substrate. Here, we overcome several challenges facing the routine realization of graphene cell sensors on a canonical soft substrate namely poly(dimethylsiloxane) (PDMS). Specifically, we have systematically studied the effect of surface energy before, during and after the transfer of graphene. Based on this, we have identified a suitable support polymer, optimal substrate (pre-) treatment and an appropriate solvent for the removal of the support. Using this procedure, we can reproducibly obtain stable and intact graphene sensors in millimeter-scale on PDMS, which can withstand continuous measurements in cell culture media for several days. From local nanomechanical measurements with an AFM, we infer that the softness of the substrate is slightly affected after graphene transfer. However, we can modulate the stiffness using PDMS of differing composition. Finally, we show that graphene sensors on PDMS can be successfully used as electrodes for real-time monitoring of cell adhesion kinetics on a soft substrate. The routine availability of single layer graphene electrodes on a flexible soft substrate with tunable stiffness will open a new avenue for a range of studies, where the PDMS-liquid interface is made conducting with minimal alteration of the intrinsic material properties such as softness, flexibility, elasticity and transparency.
Kinetics of N2 Release from Diazo Compounds: A Combined Machine Learning-Density Functional Theory Study
Authors: Farshadfar Kaveh , Hashemi Arsalan , Khakpour Reza , Laasonen Kari
Published: August 2023

Diazo compounds are commonly employed as carbene precursors in carbene transfer reactions during a variety of functionalization procedures. Release of N2 gas from diazo compounds may lead to carbene formation, and the ease of this dissociation is highly dependent on the characteristics of the substituents located in the vicinity of the diazo moiety. A quantum mechanical density functional theory assisted by machine learning was used to investigate the relationship between the chemical features of diazo compounds and the activation energy required for the N2 dissociation. Our results suggest that diazo molecules possessing a higher positive partial charge on the carbene carbon and more negative charge on the terminal nitrogen, encounter a lower energy barrier. A more positive C charge decreases the π-donor ability of the carbene lone pair to the π∗ orbital of N2 , while the more negative N charge is a result of a weak interaction between N2 lone pair and vacant p orbital of the carbene. The findings of this study can pave the way for molecular engineering for the purpose of carbene generation which serves as a crucial intermediate for many chemical transformations in synthetic chemistry.
Molecular Gas Phase Conformational Ensembles
Authors: Das Susanta , Merz, Jr. Kenneth M.
Published: August 2023

Accurately determining the global minima of a molecular structure is important in diverse scientific fields, including drug design, materials science, and chemical synthesis. Conformational search engines serve as valuable tools for exploring the extensive conformational space of molecules and identifying energetically favorable conformations. In this study, we present a comprehensive comparison of Auto3D, CREST, Balloon, and RDKit, which are freely available conformational search engines, to evaluate their effectiveness in locating the global minima. These engines employ distinct methodologies, including machine learning (ML) potential-based, semiempirical, and force field (FF) based approaches. Through rigorous analyses and employing novel approaches for validation, including the utilization of a unique physical property known as collisional cross section (CCS), which characterizes the molecular shape, size, and charge, we thoroughly assess the capabilities of these engines in generating conformation ensembles that effectively capture the global minima. To accomplish this, we created the gas-phase conformation library (GPCL) which currently consists of the full ensembles of 20 small molecules, which can be used by the community to validate any conformational search engine. Further members of the GPCL can be readily created for any molecule of interest using our standard workflow used to compute CCS values expanding the ability of the GPCL in validation exercises. These innovative validation techniques enhance our understanding of the conformational landscape and provide valuable insights into the performance of conformation generation engines. Our findings shed light on the strengths and limitations of each search engine, enabling informed decisions for their utilization in various scientific fields, where accurate molecular structure determination is crucial for understanding biological activity and designing targeted interventions. By facilitating the identification of reliable conformations, this study significantly contributes to enhancing the efficiency and accuracy of molecular structure determination, with a particular focus on metabolite structure elucidation. The findings of this research also provide valuable insights for developing effective workflows in predicting the structures of unknown compounds with high precision.
Site-directed Conjugation of Single-Stranded DNA to Affinity Proteins: Quantifying the Importance of Conjugation Strategy
Authors: Rocha Tapia Andres , Abgottspon Fabrice , Nilvebrant Johan , Nygren Per-Åke , Duclos Ivetich Sarah , Bello Hernandez Andres Javier , Thanasi Ioanna A. , Szijj Peter A. , Sekkat Ghali , Cuenot François M. , Chudasama Vijay , Aceto Nicola , deMello Andrew , Richards Daniel
Published: August 2023

Affinity protein–oligonucleotide conjugates are increasingly being explored as diagnostic and therapeutic tools. Despite growing interest, these probes are typically constructed using outdated, non-selective chemistries, and little has been done to investigate how conjugation to oligonucleotides influences the function of affinity proteins. Herein, we report a novel site-selective conjugation method for furnishing affinity protein–oligonucleotide conjugates in a 93% yield within fifteen minutes. Using SPR, we explore how the choice of affinity protein, conjugation strategy, and DNA length impact target binding and reveal the deleterious effects of non-specific conjugation methods. Furthermore, we show that these adverse effects can be minimised by employing our site-selective conjugation strategy, leading to improved performance in an immuno-PCR assay. Finally, we investigate the interactions between affinity protein–oligonucleotide conjugates and live cells, demonstrating the benefits of site-selective conjugation. This work provides critical insight into the importance of conjugation strategy when constructing affinity protein–oligonucleotide conjugates.
Shining light on inverted singlet-triplet emitters
Authors: Bedogni Matteo , Giavazzi Davide , Di Maiolo Francesco , Painelli Anna
Published: August 2023

The inversion of the lowest singlet and triplet excited states, observed in several triangle-shaped organic molecules containing conjugated carbon and nitrogen atoms, is an astonishing result that implies the breakdown of Hund's rule. The phenomenon attracted interest for its potential towards triplet harvesting in organic LEDs. On a more fundamental vein, the singlet-triplet (ST) inversion sheds new light on the role of electron correlations in the excited state landscape of pi-conjugated molecules. Relying on the celebrated Pariser-Parr-Pople model, the simplest model for correlated electrons in pi-conjugated systems, we demonstrate that the ST inversion does not require triangle-shaped molecules nor any specific molecular symmetry. Indeed, the ST inversion does not require strictly non-overlapping HOMO and LUMO orbitals, but rather a small gap and a small exchange integral between the frontier orbitals.
Interplay between Growth Mechanism, Materials Chemistry, and Band Gap Characteristics in Sputtered Thin Films of Chalcogenide Perovskite BaZrS3
Authors: Mukherjee Soham , Riva Stefania , Comparotto Corrado , Johansson Fredrik O. L. , Man Gabriel J. , Phuyal Dibya , Simonov Konstantin , Just Justus , Klementiev Konstantin , Butorin Sergei , Scragg Jonathan , Rensmo Håkan
Published: August 2023

The prototypical chalcogenide perovskite BaZrS3, with its direct band gap, exceptionally strong light-harvesting ability and good carrier transport properties, provides fundamental prerequisites for a promising photovoltaic material. This inspired synthesis of BaZrS3 in the form of thin films, using sputtering and rapid thermal processing, aimed at device fabrication for future optoelectronic applications. Using a combination of long- and short-range structural information from x-ray absorption spectroscopy (XAS) and x-ray diffraction (XRD), we have elucidated how, starting from a random network of Ba, Zr, S atoms, thermal treatment induces crystallization and growth of BaZrS3 and explained its impact on observed PL properties. We also provide an electronic structure description and confirm the surface material chemistry using a combination of depth-dependent Photoelectron Spectroscopy (PES) using Hard X-ray (HAXPES) and traditional Al Kα radiation. From the knowledge of the optical band gap of BaZrS3 thin films, synthesized at an optimal temperature of 900°C, and our estimation of the valence band edge position with respect to the Fermi level, one may conclude that these semiconductor films are intrinsic in nature with a slight n-type character. A detailed understanding of the growth mechanism and electronic structure of BaZrS3 thin films helps pave the way for their use in photovoltaics.
Synthesis, Characterization, and Single-Crystal X-ray Structures of d0 Refractory Metal Compounds as Precursors for the Single-Source Chemical Vapor Deposition of Metal Nitrides
Authors: Lawford Kieran , Land Michael , Goodwin Eden , Robertson Katherine , Barry Seán
Published: August 2023

The chemical vapor deposition of refractory metal nitrides requires volatile precursors and has previously been achieved using metal complexes containing a variety of imide ligands. Recently the 1,4-di-tert-butyl-1,3-diazabutadiene (DAD) adduct of bis(tert-butylimide)dichloridemolybdenum(VI) was shown to be an excellent precursor for the single-source CVD of Mo2N thin films. Leveraging the success of this work, we have prepared chromium and tungsten compounds with the same framework. Additionally, the framework has been modified slightly to allow the isolation of mono(tert-butylimide)trichloride complexes of vanadium, niobium, tantalum, and molybdenum(V) to extend the search for new vapor phase precursors. These compounds were all fully characterized using the standard methods of multi-nuclear magnetic resonance spectroscopy, combustion analysis, and single-crystal X-ray diffraction. Their thermal properties were determined using thermogravimetric analysis and differential scanning colorimetry to assess their utility as vapor phase precursors. Finally, preliminary deposition studies were carried out to investigate their potential as single-source CVD precursors.
Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species
Authors: Jung Erik , Kraimps Anastassia , Dittmann Silvia , Griesser Tizian , Costafrolaz Jordan , Mattenberger Yves , Jurt Simon , Viollier Patrick H. , Sander Peter , Sievers Susanne , Gademann Karl
Published: August 2023

Fidaxomicin (Fdx) is a natural product antibiotic with potent activity against Clostridioides difficile and other Gram-positive bacteria such as Mycobacterium tuberculosis. Only few Fdx derivatives have been synthesized and examined for their biological activity in the 50 years since its discovery. Fdx has a well- studied mechanism of action, namely inhibition of the bacterial RNA polymerase. Yet, the targeted organisms harbor different target protein sequences, which poses a challenge for the rational development of new semisynthetic Fdx derivatives. We introduced substituents on the two phenolic hydroxy groups of Fdx and evaluated the resulting trends in antibiotic activity against M. tuberculosis, C. difficile, and the Gram-negative model organism Caulobacter crescentus. As suggested by the target protein structures, we identified the preferable derivatisation site for each organism. The derivative ortho-methyl Fdx also exhibited activity against the Gram-negative C. crescentus wild type, a first for fidaxomicin antibiotics. These insights will guide the synthesis of next-generation fidaxomicin antibiotics.
Phytochemical and Hepatoprotective Activity of Prosopis juliflora Barks on Different Models
Authors: K Hemamalini , Palle Sadanandam , Vijayabhaskar Kanakam , U Supraja
Published: August 2023

Liver injury is a common disorder where natural remedies are practiced from ancient time from plant source which shows alternative treatment in a safe manner. The Hepatoprotective activity of methanolic extract of Prosopis juiliflora bark part was taken for evaluation in screening. The model chosen for the study is carbon tetrachloride (0.1ml/kg) and the standard drug silymarin of 20mg/kg was used for the study for 21 days. The hepatoprotective effect of the methanolic extract against the carbon tetrachloride-induced hepatotoxicity in wistar rats has been demonstrated by the substantial and severe reduction of enzymes in the serum.
Business Cycles and Low-Frequency Fluctuations in the US Unemployment Rate
Authors: Lunsford Kurt G.
Published: August 2023

I show that business cycles can generate most of the low-frequency movements in the unemployment rate. First, I provide evidence that the unemployment rate is stationary, while its flows have unit roots. Then, I model the log unemployment rate as the error correction term of log labor flows in a vector error correction model (VECM) with intercepts that change over the business cycle. Feeding historical expansions and recessions into the VECM generates large low-frequency movements in the unemployment rate. Frequent recessions from the late 1960s to the early 1980s interrupt labor market recoveries and ratchet the unemployment rate upward. Long expansions in the 1980s and 1990s undo this upward ratcheting. Finally, the VECM predicts that the unemployment rate will be near 3.6 percent after a 10-year expansion and that lower unemployment rates are possible with longer expansions.
Las estrellas de Orión
Authors: Ciobanu Andreea
Published: August 2023

A pregnant woman enters a grocery store in the middle of the pandemic. She bears the weight of work, familial drama, and the future. Her experiences highlight the obstacles employed women face in the United States and the lack of social concern and support for expecting mothers.
Conversions of uracil , glycine , and glucose arriving in forest litter of sod-podzolic soil as litter compounds
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Zhuravleva O.S. , Torshin S.P.
Published: August 2023

In model experiments under forest ecosystem conditions, samples of partially decomposed forest litter and soil from a 0–10 cm layer containing 14C-labeled organic matter were selected. The label was introduced in the form of low molecular weight water-soluble organic substances of individual nature – glycine, uracil and glucose together with unlabelled plant litter in nylon bags. The experiment was carried out in the late autumn period on the territory of the Malinsky forestry, 20 km south-west of Moscow, on a medium loamy sod-podzolic soil. For the study, samples were taken from two selection periods – 40 days after labelling and after two years. The selected samples were extracted and separated into soil organic matter fractions containing 14C in their composition, followed by radiometry. The results showed differences in the transformation and incorporation of radiocarbon of the studied products – glycine, uracil, and glucose into different fractions of soil organic matter of low molecular weight water-soluble substances, depending on their nature.
Strategic priorities for the development of the viticulture industry on the example of the Republic of Dagestan
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Sharipov Sh.I. , Rykova I.N. , Yur’eva A.A.
Published: August 2023

The article presents the results of research on the viticulture industry in the Republic of Dagestan in terms of dynamic changes in the retrospective period of indicators characterising the development of the industry in the region. The aim of the research was to carry out a comprehensive analysis and evaluation of the development of viticulture in the Republic in order to identify the main trends characterising the development of the industry in the context of the implementation of the strategic goals of the region in this area. The analysis was based on the use of quantitative, statistical and comparative methods, as well as methods of analogy, synthesis and generalisation of the data obtained. The relevance of the research is based on the need to assess the achievement of the regional strategic objectives in the field of restoration and development of viticulture in the Republic and to elaborate further measures for the development of the industry. The scientific novelty lies in the systematisation and assessment of the state of viticulture in the Republic of Dagestan using an integrated approach to analysis, including the assessment of the entire set of indicators of the production process, from the production cycle to the assessment of consumer prices for grapes. The results of the study, in the context of positive trends in the development of the viticulture industry in the Republic of Dagestan, showed that there is significant potential in the region for increasing the production capacity of the viticulture industry and increasing the volume of products for sale both within the Republic and mutual trade regions, as well as for export.
Determination of the cost of prolonged hospitalization in cardiovascular surgery intensive care unit to the institution
Authors: Üçüncüoğlu Melek , Ocak İsmail Hakkı
Published: August 2023

In the provision of health services, health institutions should be perceived as an enterprise to use limited resources most effectively and efficiently, evaluate them optimally and ensure production efficiency. Therefore, cost information enables the most efficient utilization of resources in hospital enterprises and allows managers to use decision-making mechanisms most accurately. This study was conducted to determine and compare the costs of prolonged hospitalizations in the cardiovascular surgery intensive care unit of a university hospital. Our study was descriptive and retrospective. The hospitalizations in the cardiovascular surgery intensive care unit of the hospital were analyzed according to the prolonged hospitalization criteria determined by the social security institution. 29 extended hospitalization patient bills were determined in three years. The mean age of the prolonged hospitalization of patients was 67 years, the duration of hospitalization was 680 days, and the mean hospitalization day was 18.64. The items with the highest expenditure in prolonged hospitalization of patients were determined as drug costs, general applications and intervention costs, medical consumables costs, and laboratory costs. The increase in costs during the hospitalization and treatment process is mainly due to medication, general practices, interventions, and medical consumables. Related decision-makers should make root-cause analyses, and plans should be made to reduce costs.
СИНТЕЗ И МОЛЕКУЛЯРНАЯ СТРУКТУРА 1a-ГИДРОКСИ-13-ИЗОПРОПИЛ-7,10a-ДИМЕТИЛ-4-ОКСООКТАДЕКАГИДРО-4b,12-МЕТАНОХРИЗЕНО[1,12-bc]ФУРАН-7-КАРБОНОВОЙ КИСЛОТЫ И МЕТИЛ 1b-АЦЕТОКСИ-13-АЦЕТИЛ-7,10a-ДИМЕТИЛ-4-ОКСОГЕКСАДЕКАГИДРО-1H-4b,12-ЭТЕНОХРИЗЕН-7-КАРБОКСИЛАТА
Authors: Третьякова Е.В. , Рыбалова Т.В. , Половяненко Д.Н.
Published: August 2023

В результате окисления озоном 1 b,13-эпоксидигидрохинопимаровой кислоты и метилового эфира 1b-гидроксидигидрохинопимаровой кислоты осуществлен синтез новых оксифункционализированных производных, молекулярно-кристаллическая структура которых определена методом РСА. 1a-Гидрокси-13-изопропил-7,10a-диметил-4-оксооктадекагидро-4b,12-метанохризено[1,12-bc]фуран-7-карбоновая кислота (II) представлена в форме кристаллогидрата моноклинной сингонии c пространственной группой P21, a 12.3886(6), b 6.9442(3), c 13.7037(6) Å, β 93.290(2)°. Наличие молекул воды приводит к образованию двумерной сетки водородных связей, формирующих молекулярные слои, параллельные (a, b). Кристаллы метил 1b-ацетокси-13-ацетил-7,10a-диметил-4-оксогексадекагидро-1H-4b,12-этенохризен-7-карбоксилата (IV) ромбические, пространственная группа P212121, a 8.3760(3), b 16.2470(5), c 18.5603(6) Å.
Features of prediction and diagnosis of intra-abdominal hypertension in cardiac surgery (clinical study)
Authors: Podoksenov Yu. K. , Svirko Yu. S. , Kozlov B. N. , Ladik U. A. , Diakova M. L. , Kamenshchikov N. O. , Gusakova A. M. , Trubacheva O. А. , Churilina E. A. , Te M. A.
Published: August 2023

Aim. To test the hypothesis that early detection of clinically significant patients with high risk of developing intra-abdominal hypertension in cardiac surgery may be based on an increase in the level of fatty acid-binding protein.

Material and Methods. Concentrations of fatty acid-binding protein (I-FABP) were measured in urine samples taken from 82 patients after cardiac surgery with cardiopulmonary bypass. The data were compared with clinical manifestations of the perioperative period, as well as changes in pH and lactate levels in arterial blood.

Results. Statistically significant differences were revealed between the study groups in the cases of increased intra-abdominal pressure, duration of ventilation, and the number of cases of intestinal failure. The level of I-FABP increased in the patients of both groups after removal of the aortic clamp in 2 hours, 12 hours, 24 hours after surgery. 

Conclusions. The I-FABP level can be a valuable marker for early detection of patients with the development intra-abdominal hypertension of after cardiac surgery.  The measurement of I-FABP can serve as a guideline not only for the identification of patients with intra-abdominal hypertension, but also for the initiation of therapeutic measures aimed at minimizing further deterioration of intestinal function.
Human-centricity is a new trend in the organization of the work of tax authorities
Authors:   Финансовый университет при Правительстве РФ, МАНДРОЩЕНКО О.В.
Published: August 2023

В эпоху цифровых технологий заметно меняется спектр услуг и способ их предоставления, что способствует демократизации процедур принятия решений, внедрению принципов человекоцентричности. В статье раскрыты положительные направления работы налоговых органов в этой сфере, выявлены проблемы и предложены пути их решения. В частности, подчеркивается, что ФНС России созданы электронные офисы налогоплательщиков, цифровые системы налогового контроля, особый порядок уплаты налогов в форме единого налогового платежа (ЕНП). Тем не менее налогоплательщики все еще рассматривают налоговые органы как бюрократическую структуру. В связи с этим в статье предлагается, чтобы налоговые органы стали более активно заниматься методологической работой, всесторонне обосновывать выводы и предложения по устранению выявленных нарушений в ходе налоговых проверок, строить коммуникации на взаимопонимании и доверии, обратной связи с налогоплательщиками.
The current state, ways of improvement and prospects for the development of e-commerce on marketplaces
Authors:   Академия управления и производства, ОВСИЙЧУК В.В. , СОКЛАКОВА И.В. ,   Московский городской университет управления Правительства Москвы им. Ю.М. Лужкова, КУЗЬМИНА Е.Ю. ,   Государственный университет управления, КОЧКУРОВА Е.О. ,   Технологический университет имени дважды Героя Советского Союза, летчика-космонавта А. А. Леонова
Published: August 2023

В статье анализируется современное состояние, раскрываются пути совершенствования и дается оценка перспектив развития торговли товарами и услугами на интернет-платформах-маркетплейсах.Выявлены недостатки торговли на маркетплейсах (случаи поддержки известных брендов, продажи некачественных товаров и др.). В заключении обобщены результаты исследования.
Biopolítica y medicalización: un análisis de la pandemia por Covid-19 desde Michel Foucault
Authors: Velasco Cañas Diego Fernando , Contreras Landgrave Georgina , Ibarra Espinoza Manuel Leonardo
Published: August 2023

El presente texto constituye una reflexión desde la noción de biopolítica de Michel Foucault, se parte de los escritos genealógicos del autor en los que plantea el desarrollo de la medicina social y los procesos de medicalización de la sociedad para realizar un contraste con la situación social y política provocada por la pandemia de COVID-19 a nivel mundial. El objetivo del escrito es proponer una mirada crítica al ejercicio del biopoder que se justifica desde el miedo y lo que este provoca como enseñanza social.
La prescripción categorial de leyes en los procesos de teorización
Authors: Covarrubias Villa Francisco , Cruz Navarro Ma. Guadalupe , Gálvez Ordaz Luis Armando
Published: August 2023

Este escrito reflexiona las condiciones en las que las categorías prescriben leyes del entendimiento y cómo son concebidas existentes en lo pensado. Kant formula el carácter prescriptivo legal de las categorías, su carácter apriorístico y su estatus de forma de pensamiento y concepto puro, abriendo la posibilidad de otorgarles contenido general como conceptos absolutos (Hegel) o como expresión de lo real (Marx). Las categorías rigen la apropiación empírica, mágico-religiosa, artística o teórica de objetos y fenómenos. El pensamiento categorial despojado de conceptos fue formulado y denominado razón teórica por Kant, Hegel anhela pensar con conceptos y Marx construye modelos teóricos puros categoriales.
¿Gobierno para las mayorías o para élites dogmáticas?
Authors: Pérez Mendoza Araceli
Published: August 2023

Reseña del libro:

González, P. y Ortiz, S. (2021). El debate del pensamiento político contemporáneo.  Una aproximación al liberalismo, republicanismo, comunitarismo y multiculturalismo. México: UNAM / Gedisa.
Robot-assisted partial nephrectomy with zero ischemia in comorbid patients.
Authors:   department of urology with the course of robotic surgery with clinic, head of the center for robotic surgery of Almazov National Medical Research Centre of the Ministry of Health of Russian Federation, Mosoyan M.S. ,   St Petersburg, Russia, Shanava G.Sh. ,   Department of Urology with the Course of Robotic Surgery with Clinic, Almazov National Medical Research Centre; St Petersburg, Russia, Simonyan A.M. ,   Department of Urology with the Course of Robotic Surgery with Clinic, Almazov National Medical Research Centre of the Ministry of Health of Russian Federation; St Petersburg, Russia, Gilev E.S. ,   department of urology with a course of robotic surgery with clinic, Almazov National Medical Research Centre of the Ministry of Health of Russian Federation; St Petersburg, Russia, Aysina N.A. ,   department of urology with a course of robotic surgery with clinic, Almazov National Medical Research Centre of the Ministry of Health of Russian Federation; St Petersburg, Russia
Published: August 2023

Introduction. Nephron-sparing surgery is the current gold standard for the surgical treatment of localized renal cell carcinoma (RCC). Partial nephrectomy can be performed by off-clamp or on clamp techniques. It is especially important to preserve renal function during partial nephrectomy in comorbid patients. Objective. To evaluate the perioperative results of robot-assisted partial nephrectomy with zero ischemia in comorbid patients with RCC. Materials and Methods. At the Almazov Center we retrospectively studied the results of 11 comorbid patients who underwent robot-assisted partial nephrectomy with zero ischemia from 2019 to 2022. In 3 (27.3%) of them, renal mass was detected in a solitary kidney. In preoperative period 3D reconstruction was performed using the 3D Slicer modeling program. For rapid mobilization of the renal vessels we used «method of safe exposure of renal pedicle vessels during endovideosurgical resection of the kidney and radical nephrectomy during laparoscopic and robot-assisted operations» (patent RU 2742367). The boundaries of resection were determined with an intracavitary ultrasound probe BK Flex Focus 800. Renal function was assessed by glomerular filtration rate (GFR) using the Chronic Kidney Desease Epidemiology Collaboration (CKD-EPI) formula. Results. There were no intraoperative and postoperative complications. The median console operation time was 110 min [58–130]. Median estimate blood loss was 100 ml [50-280]. No cases had a positive surgical margin. In the postoperative period, GFR was comparable to preoperative values. Conclusion. Robot-assisted partial nephrectomy with zero ischemia for comorbid patients is more expedient to be performed in a multidisciplinary center of competence. The effectiveness of perioperative results of robot-assisted partial nephrectomy with zero ischemia is achieved by using highly informative diagnostic imaging methods and performing a safe method of isolating renal vessels during the operation with rapid renorrhaphy performed by an experienced surgeon.
Frequency of seroma formation after modified radical mastectomy. A comparison between electrocautery and scalpel dissection techniques.
Authors: Zain Bashir  , Muhammad Taimur  , Muhammad Imran  , Inamullah Shah  , Mahvish Noor  , Burhan Ahmad
Published: August 2023

Objective: To compare the use of electrocautery and scalpel dissection while performing modified radical mastectomy in terms of frequency of seroma formation. Study Design: Randomized Clinical Trial. Setting: Department of Surgery, Fauji Foundation Hospital, Rawalpindi. Period: 19-06-2019 to 22-06-2022. Material & Methods: A total of one hundred (n=100) female patients between age 22-60 years, who underwent modified radical mastectomy for breast carcinoma were enrolled in the study and randomized into two groups. Electrocautery dissection was performed in group A while patient in group B will undergo Scalpel dissection. Outcome was measured in terms of seroma formation at 7th day postoperatively. Results: Mean age of patients in our study was 42.39 years and standard deviation 8.26. At day 7 after the surgery, mean drain volume was 39.77 ml in our patients. Seroma formation was observed in a total of 14(28%) patients in group A (electrocautery) and 8(16%) patients in group B (Scalpel). Conclusion: Frequency of seroma formation was significantly lower with scalpel dissection as compared to those with electrocautery dissection after MRM.
EFFECT OF PLATING PATTERN AND NITROGEN FERTILIZATION ON SORGHUM +BLACKGRAM INTERCROPPING UNDER DRYLAND CONDITIONS
Authors:   Dept of Agronomy  Rajasthan College of Agriculture Udaipur 313 001, M.L GUPTA
Published: August 2023

Intercropping of blackgram and sorghum with various planing patterns and nitrogen levels were tried at Agricultural Research Station, Aklera (Jhalawar) Rajasthan during Kharif, 1977, 78 and 1979. Altemate planting of sorghum and urd at 22.5 cm or paired planting of sorghum at 35 cm and one row of urd in between pairs of sorghum were found equally good and proved better than other ried systems of intercropping or sole cropping. Application of nitrogen to the sorghum crop in intercropping was as good as sole sorghum. However, nitrogen application to sorghum crop reduced the yield of intercrop.
COMBINING ABILITY ANALYSIS IN F1 AND F2 DIALLEL FOR YIELD AND QUALITY IN COTTON (G. hirsutum) Linn.
Authors:   Assitant Breader, Cotton Research Station Nanded 431 602, S.S Mane , S.S Phatade ,   Assitant Breader, Cotton Research Station Nanded 431 602
Published: August 2023

Combining ability analysis was carried out in a 6x6 diallel cross of F1 and F2 population for three important traits of cotton corp. Seed cotton yield, ginning outturn and fibre length were found to be controlled by both additive and non-additive gene action with predominance of additive gene action. G cot 10 was found to be best general combiner for yield whereas 'Acale 4-42' for ginning outturn as well as halo length. per se performance of parents was good indicator of their general combining ability crosses showing high sca effects involved parents with high, medium and low gca effects for yield. Suitable breeding method for exploitation of the available variability is described.
MICROORGANISMS ASSOCIATED WITH BOLL ROT DISEASES OF COTTON (Gossypium hirsutum)
Authors:   Centre for Plant Protection Studies, Tamil Nadu Agricultural University Coimbatore  641 003, K ILANGO , S UTHAMASAMY ,   Centre for Plant Protection Studies, Tamil Nadu Agricultural University Coimbatore  641 003
Published: August 2023

Nane species of fungi and one bacterium were found to be associated with the boll rot discase of cotton. Rhizopus stolonifer, Fusarium moniliforme, Trichotheclum sp., F. oxysporum and Aspergillus flavus, were more common. Penicillium sp. and Mucor sp. were not pathogenic. R.stolonifer caused complete boll rotting in five days whereas with Xanthomonas campestries pv. malvacearum boll rotting was competed in 12 days.
EFFECT OF N LEVELS AND SOILS ON THE N, P AND K UPTAKE BY MAIZE
Authors:   Tamil Nadu Agricultural University Coimbatore  641 003 Tamilnadu, S BASKARAN , P KANDASAMY ,   Tamil Nadu Agricultural University Coimbatore  641 003 Tamilnadu, T.S MANICKAM ,   Tamil Nadu Agricultural University Coimbatore  641 003 Tamilnadu
Published: August 2023

Pot culture experiment conducted with fifteen soils (ten representing low N and five medium N soils) under graded doses of N to study the uptake of nutrients revealed that the N P K uptake showed a positive trend with N application at all stages of crop growth. Application of 202.5 Kg N/ha recorded the highest N uptake by shoot and grain. The N uptake was higher in medium N soils compared to low N soils.