bluuebunny/crossref_metadata_2025 huggingface dataset:
Compatibility between Magnesium Stearate and Pharmaceutical Acidic Active Compounds/Excipients with DSC
Authors: Chaiya Pornsit , Phaechamud Thawatchai
Published: August 2020

Compatibility investigation was performed between magnesium stearate and acidic drug compounds (ibuprofen, indomethacin and valproic acid) and acidic pharmaceutical excipients (lactic acid and citric acid) using differential scanning calorimetry (DSC). DSC study indicated the possible incompatibility for the mixture between magnesium stearate and any compounds. Alteration in DSC thermogram was found in all mixtures. The eutectic phenomenon was found in the powder mixture of magnesium stearate and ibuprofen. In addition, the presence of melting endothermic peak of stearic acid in other powder mixtures except the mixture of magnesium stearate and indomethacin indicating breakage of salt form of magnesium stearate. This alteration could relate to the influence on physicochemical properties of drug compounds and pharmaceutical excipients which powder x-ray diffraction (PXRD) and Fourier Transform Infrared Spectroscopy (FT-IR) should be further analyzed to confirm the interactions between compounds.
Emulsification of Water in Fuel Oil Emulsion by Phase Inversion
Authors: Kittipoomwong Prakorn , Panasuppamassadu Karn , Narasingha Monpilai
Published: August 2020

Emulsification of water and fuel oil emulsion was experimentally investigated. The water-in-oil emulsion was produced with ultrasonic mixer and phase inversion concentration using a mixture of Span80 and Tween80 as emulsifiers. The emulsion was characterized by water droplet size, distribution and visual observation of microscopy photographs. Water in fuel oil emulsion prepared by phase inversion concentration was found to be similar to that prepared by the ultrasonic mixer in term of average droplet size and distribution
Synthesis of Palladium Chloride Impregnated on Al2O3- Pillared Clay for Reduction of Nitrobenzene
Authors: Trikittiwong Piyarat , Maliwong Jedsada
Published: August 2020

Palladium chloride impregnated on Al2O3-pillared clay (Pd/Al-PILC) was synthesized by intercalation of aluminium (III) chloride into clay interlayers and calcined at 500°C for 1 h. Subsequently, impregnated with PdCl2 and calcination at 450°C for 4 h. The modified clay catalyst was characterized by X-ray diffraction (XRD) for investigated atomic spacing of catalysts and N2 adsorption and desorption method (BET) for investigated surface area and pore volume of catalysts. The catalytic activities of Pd/Al-PILC was utilized for the reduction of nitrobenzene for synthesis aniline. The effect of various reaction factors, such as reaction time, reaction temperature, solvent system and the amount of catalyst were studied in order to optimize the reaction conditions. Aniline was prepared conveniently and efficiently via the reduction of nitrobenzene in the presence of a catalytic amount 40%Pd/Al-PILC of substrate in reflux temperature at 70°C for 4 h under extremely mild conditions.
Phase Inversion-Induced Rosin In Situ Forming Matrix Using Various Organic Biocompatible Solvents for Periodontitis Treatment
Authors: Lertsuphotvanit Nutdanai , Mahadlek Jongjan , Tuntarawongsa Sarun , Phaechamud Thawatchai
Published: August 2020

In situ forming matrix (ISM) is an injectable drug delivery system containing a drug-loaded polymeric solution. It was applied for local drug administration such as into a periodontal pocket for periodontitis treatment with an antimicrobial agent. ISM can transform with phase inversion into the solid-like matrix after contact an aqueous environment by solvent exchange mechanism. This study aims to develop ISM which various concentrations of rosin (R) as matrix former dissolved in organic biocompatible and biodegradable solvents such as N-methyl-2-pyrrolidone, dimethyl sulfoxide and 2-pyrrolidone. Physicochemical characterization and matrix formation behavior owing to phase inversion of R ISM were evaluated including pH, density, viscosity, contact angles, surface tension, expelling force through a syringe, matrix formation behavior and morphological change. The density of all R ISM exhibited in the range of 1.03-1.11 g/cm3 and contact angles (9.04-44.13°) indicated a good wetting property. Higher R concentration decreased pH of ISM owing to increased amount of abietic and pimaric acid from R while the viscosity, contact angles and force for expelling a syringe were increased. The viscosity of R ISM in dimethyl sulfoxide was less than that in 2-pyrrolidone; thus, ISM using dimethyl sulfoxide as a solvent exhibited good injectability. ISM comprising R concentration > 30%w/w promoted a faster matrix growth in which the amount of occurred R matrix was enhanced with time and the rate of matrix formation was lower with time. Doxycycline Hyclate (Dx)-loaded 40%w/w ISM in dimethyl sulfoxide (Dx-DR) had pH of 3.70, density of 1.1084 ± 0.0005 g/ml, viscosity of 35.72 ± 0.00 cPs, contact angles of 26.87 ± 2.40°, surface tension of 37.11 ± 0.11 mN/m and expelling force of 23.98 ± 0.18 N. It showed the sustainable Dx release in simulated crevicular fluid and the efficient antimicrobial activity against Staphylococcus aureus and Porphyromonas gingivalis. Thus, this phase inversion induced R ISM using dimethyl sulfoxide as a solvent showed potential as an antimicrobial agent-loaded drug delivery system for periodontitis treatment.
Electrically Conducting Poly(Pyrrole-co-Para-Phenylenediamine) as Potentiometric Transducers in Urea Biosensor Fabrication
Authors: Prissanaroon-Ouajai Walaiporn , Sirivat Anuvat
Published: August 2020

This research has focused on the fabrication of a urea biosensor based on electrically conducting poly (pyrrole-co-para-phenylenediamine) (PPy-co-PPD). High amount of free amino groups (-NH2), originating from PPD, in the PPy-co-PPD structures made them suitable for chemical immobilization of urease. The PPy-co-PPD films were prepared by one-step electrodeposition of the mixture of pyrrole and PPD. It was found that the morphology and conductivity of the PPy-co-PPD films were influenced by amount of PPD in the copolymer. Increasing amount of PPD in the copolymer led to decreasing electrical conductivity. Greater particle size and less packing were observed for the copolymer with high PPD content. XPS revealed the existence of free amino groups (-NH2) on the surface of PPy-co-PPD films. The PPy-co-PPD films were further subjected for covalent immobilization of urease, selective catalytic enzyme for urea. Potentiometric responses of the PPy-co-PPD films showed the highest sensitivity of 47.3-54.2 mV/pUrea (r2 > 0.99) over the urea concentration ranging from 0.5-10.0 mM (pUrea 2.0-3.3). Detection limits and response linearity were in the normal range of urea level. Response time was approximately 10 seconds. Leaching test revealed that the PPy-co-PPD film showed 83% reduction of urease leaching out of the PPy-co-PPD film during measurement, compared to the PPy film.
New Emerging Al7075 Based Hybrid Nanocomposite for Automotive Applications: A Sustainability Approach
Authors: Mahanta Sweety , Chandrasekaran Muthumari , Samanta Sutanu
Published: August 2020

Aluminium matrix composites (AMCs) have emerged as the substitute for the monolithic (unreinforced) materials over the past few decades. The applications of AMCs are common in automotive, aerospace, defence and biomedical sectors due to its lower weight, high strength, high resistance against corrosion and high thermal and electrical conductivity. In this work, it is aimed fabricate a new class Al 7075 based hybrid composites reinforcing with nanoparticulates suitable for automotive application. Al7075 reinforced with fixed quantity of boron carbide (B4C) (1.5 wt.%) and varying wt % of flyash (0.5 wt.%, 1.0 wt.%, 1.5 wt.%) is fabricated using ultrasonic-assisted stir casting technique. Physical and mechanical characterization such as density, porosity, micro hardness, tensile strength and impact strength were estimated for three different compositions. The tensile strength and percentage increase in hardness value of the nanocomposite Al7075-B4C (1.5 wt. %)-flyash (0.5 wt. %): HNC3 found maximum as 294 MPa and 32.93%. In comparison with Al7075 alloy the impact strength of HNC3 shows the highest percentage of 9.31% respectively.
Case Depth Evaluation of Induction Hardened Steel Using Barkhausen Noise Technique
Authors: Nitjarunkul Porawon , Primee Sai Yan , Chongbunwatana Komkamol , Seemuang Nopparat
Published: August 2020

Barkhausen noise (BHN) measurement is one of electromagnetic testing methods that is suitable for ferromagnetic materials. It has a sensitivity to different material properties such as microstructure, composition, residue stress, hardness, etc. which can also be used to determine the hardness case depth of a hardened layer. The measurement is intriguing because of its time and cost-effectiveness. The aim of this work was to study and select a suitable method to evaluate and predict the hardness case depth of induction hardened S50C steel based on Barkhausen noise measurement. Signal processing of BHN signal was performed and extracted features were validated with the actual hardness case depth according to the destructive method of Vickers hardness and metallography in order to achieve the most accurate hardness case depth evaluation model. The results showed that the hardness case depth prediction model could be used to indicate the hardness case depth of induction hardened steel significantly at the correlation coefficient (R) of 0.97 and root mean squares error of estimation (RMSEE) of 3.56%.
Crystallization Behaviors of Plasticized Poly(Lactic Acid)/Microcrystalline Cellulose Composite Sheet
Authors: Phongtamrug Suttinun , Ouajai Sirisart
Published: August 2020

Poly(lactic acid) (PLA) is a potential biodegradable polymer to replace petroleum-based plastic, however, its main drawback is brittleness because of slow crystallization rate. To overcome this limitation, compounding with some additives is the most chosen choice due to easy and effective preparation. In this study, an epoxidized soybean oil (ESO) and a microcrystalline cellulose (MCC) were applied as a plasticizer and a nucleating agent, respectively. The PLA was compounded with ESO and MCC by using a twin-screw extruder. The product sheets were prepared by using a chill-roll cast film extruder. Change of thermal property after adding ESO and MCC was investigated by a differential scanning calorimeter. Mechanical property of the prepared sheet was carried out by using a universal testing machine in a tensile mode. Microstructure of the sheets was also studied by wide angle X-ray diffraction (WAXD) and small angle X-ray scattering (SAXS) techniques. The results showed that ESO assisted plasticization while the MCC induced crystallization of PLA. Also, ESO and MCC eased flowability and alignment of PLA microstructure in machine direction.
Effects of Rubber and Mould Temperatures on the Solid Tire Curing Process
Authors: Limrungruengrat Sitthichai , Chaikittiratana Arisara , Chantrasmi Tonkid , Pornpeerakeat Sacharuck , Suripa Utid
Published: August 2020

Vulcanization or curing process is a very important process in producing useful rubber products. The quality, performance as well as manufacturing cost of a rubber product are largely affected by the curing process. The curing process takes place when heat is transferred to the rubber compounds inside a heated mould. Curing of a thick article, such as a solid tire, often occurs under transient non-isothermal conditions. The temperature distribution in the rubber significantly affects the cure level distribution throughout the part, especially in a large rubber component. Therefore the ability to predict the distribution of cure level in a rubber part during curing is of great importance for improving the process efficiency and the quality of the final product. In this work, simulations of the curing process of a solid tire, consisting of three layers of different rubber compounds, were performed and the cure level distribution results were evaluated. The simulations are carried out using the commercial finite element software ABAQUS with the cure kinetics model for rubber implemented through the user subroutine UMATHT. The effects of the mold temperature and initial temperature of the solid tire on the cure level distribution and cure time were investigated.
Morphological, Thermal and Mechanical Properties of Poly(Lactic Acid)/Cellulose/ Nano-Clay Composite
Authors: Ouajai Sirisart , Phongtamrug Suttinun
Published: August 2020

This research has focused on the effect of modified cellulose and clay on the thermal and mechanical properties of PLA bio-nanocomposite. Cellulose was chemically modified with silane coupling agent in order to enhance compatiblization with PLA. Successful modification was confirmed by Fourier Transform Infrared Spectroscopy and EDX-SEM. PLA was compounded with various amounts and ratios of the modified cellulose and clay by a twin-screw extruder. Thermal properties of the bio-nanocomposites were characterized by Thermogravimetric Analysis and Differential Scanning Calorimetry. Glass transition temperature of the bio-nanocomposite slightly decreased whereas melting temperature remained constant when the amount of both fillers was increased. In addition, crystallization behaviour of PLA has been influenced by the type and amount of the fillers. Clay showed a greater effect on the crystallization of PLA than the modified cellulose and unmodified one, respectively. The flexural modulus of the composite containing equal amount between clay and cellulose was increased with an increasing in fillers contents. But the flexural and impact strength of composite were gradually decreased with an increase in fillers contents. Variation of clay and cellulose ratio resulted in the change of mechanical properties. The composite containing higher ratio between clay:cellulose or cellulose:clay showed a better mechnical properties comparing to the ratio of clay:cellulose equal to 1:1.
Effect of Plastic and Tire Wastes on Marshall Properties, Density and Water Absorption of Polymer Pavement
Authors: Choeycharoen Chanidapa , Techawinyutham Laongdaw , Dangtungee Rapeephun
Published: August 2020

The amount of plastic wastes and tire wastes were continuously increasing. The old tires and polymer which was low-density polyethylene (LDPE) were used to create polymer-modified pavement to get rid of plastic wastes and tire wastes replacing asphalt road. LDPE of 15 wt% was the main matrix material of the modified road pavement instead of asphalt; moreover, ground tire rubber (GTR) at various concentration of 3, 5, 7 and 10 phr was used as the additive mixed with mineral aggregates of 85 wt%. In this study, the Marshall method was used to prepare the sample. The properties of Marshall stability, Marshall flow, bulk specific gravity and voids of the polymer-modified pavement were studied for comparing to commercial asphalts. The results showed that the strength of the modified pavement increased which was higher than commercial asphalts although void concentration increased. The bulk specific gravity decreased as increasing amount of GTR. The percentage of water absorption increased as addition of GTR content. This study might be benefits in reduction of waste and valuable resources as bitumen, and also recovery an environment
Flexural Behavior of Compacted-Cement Sand Reinforced with Geogrid
Authors: Rochanavibhata Uthairith , Jamnongwong Marupatch , Chuenjaidee Supphanut , Jamsawang Pitthaya , Chen Xiao Bin
Published: August 2020

An improvement of flexural strength of cement stabilized soils using geogrid designated as compacted cement-geogrid-sand (CCGS) is investigated in this research. The studied material performance of the CCGS includes postpeak behavior, toughness, and equivalent flexural strength ratio. The geogrid inclusion significantly improves the postpeak flexural behavior, which is a requirement for bound pavement materials. The first peak flexural strength f1 and stiffness of both compacted-cement-sand (CCS) and CCGS are essentially the same for the same cement content. The tested soils were obtained from Ayutthaya province, Thailand, and is commonly used as a construction material for backfill and pavement applications. The backfill soils were used sand. In this study, Type I Portland cement was used as a cementing agent and geogrid two type were used as a reinforcement material. Properties of the cement and the geogrid, which were obtained from the manufacturers. The specimens were subjected to a flexural performance test according to ASTM C1609/C1609M-10 (2010). The results showed that in the flexural performance of the CCGS includeing postpeak behavior, toughness, and equivalent flexural strength ratio depends on the type and shape of apertures of the geogrid. It was found that the triaxial geogrid with shape of triangular apertures was more effective in reinforcing and provided the high equivalent flexural strength over uniaxial geogrid.
Unconfined Compressive and Splitting Tensile Strength of Dredged Sediments Stabilized with Cement and Fly Ash
Authors: Poorahong Hatairat , Wongvatana Nunthanis , Jamsawang Pitthaya , Lueprasert Kamolwan , Tantayopin Kullachai , Chen Xiao Bin
Published: August 2020

The main objective of this study is to investigate the mechanical properties of dredged sediments, which are considered as waste from the process of removing sediments from the bottom of a dam's reservoir. The dredged sediments with stabilization can to be reused as construction and building materials in civil engineering works. The mechanical tests included unconfined compressive strength (UCS) and splitting tensile strength (STS) to understand the behavior of the dredged sediments stabilized with ordinary portland cement (OPC) type I and fly ash (FA). The overall test results indicated that OPC type I and FA were effective in stabilizing the sampled dredged sediments from two dams in northern Thailand. The stabilization with 10% FA content was found to be most effective for improving mechanical properties of the stabilized samples.
Compressive Strength and Workability of Cement Mortar Containing Recycled Asphalt Pavement
Authors: Suebsuk Jirayut , Panpipat Panupong
Published: August 2020

This article presents the compressive strength and workability of cement mortar (CM) containing recycled asphalt pavement (RAP) as fine aggregate replacement. The effect of the RAP replacement, water to cement ratio, curing time, and aggregate water absorption on compressive strength and flow workability are reported. The results show that the mixing water and mixing time play a significant role in the compressive strength and unit weight of CM containing RAP. The RAP has a higher water absorption and slower rate of water absorption than those of sand. The flow workability of CM increases with RAP replacement due to the unabsorbed water at the initial mixing stage. The main negative factors that affected the compressive strength of CM containing RAP as a fine aggregate replacement are revealed. The unabsorbed water at the initial state of mixing before hardening causes increased flow workability and decreased compressive strength. The findings from this research will promote the mix design approach of CM containing RAP as a fine aggregate replacement, for moving toward increased applications of recycled materials in a sustainable manner in civil engineering construction.
The Properties of 0.5BZT - 0.5BCT Piezoelectric Ceramic from Gel Casting Process by Using Ethylene Glycol Diglycidyl Ether (EGDGE) Epoxy Resin as a Gelling Agent
Authors: Thongchai Tanikan
Published: August 2020

This research is concerned with properties of 0.5BZT-0.5BCT through a water based gel casting process by using Ethylene Glycol Diglycidyl Ether (EGDGE) epoxy resin as a gelling agent. A solution of an ammonium salt of an acrylic polymer in water (NH4PAA) was used as an additive in order to make the dispersion of the powders easier and provide better stability of the slurry and dispersant. The results were found that viscosities of the 0.5BZT-0.5BCT with EGDGE epoxy resin was minimised by the addition of 1.6 wt% of dispersant based on the dried powder weight. The highest green strengths of around 25 MPa were achieved at 30 wt% EGDGE resin content and 44 vol% solids loading. The gel casting samples were studied at sintering temperatures between 1300-1500 °C. The highest values of piezoelectric and dielectric properties corresponded to 0.5BZT-0.5BCT gel casting samples fabricated with a gel casting slurry incorporating 30 wt% EGDGE resin content, 44 vol% solids loading and sintered at 1500 °C, with d33 and εr values of 310 pC/N and 2515, respectively.
Numerical Simulation of Cutting Force in High Speed Machining of Inconel 718
Authors: Tamang Santosh Kumar , Teyi Nabam , Tsumkhapa Rinchin Tashi
Published: August 2020

Machining is one of the major manufacturing processes that converts a raw work piece of arbitrary size into a finished product of definite shape of predetermined size by suitably controlling the relative motion between the tool and the work. Lately, machining process is shifting towards high speed machining (HSM) from conventional machining to improve and efficiently increase production, and towards dry machining from excessive coolant used wet machining to improve economy of production. And the tools used are mostly hardened alloys to facilitate HSM. The work piece materials are continually improving their properties by emergence and development of newer and high resistive super alloys (HRSA). In this paper an attempt has been made to validate an experimental result of cutting force obtained by performing HSM on an HRSA Inconel 718, by comparing it with the numerical result obtained by simulating the same setting using DEFORM 3D software. Based on the comparison it is found that the simulated results exhibit close proximity with the experimental results validating the experimental results and the effectiveness of the software.
Effect of Cooling Rate on Microstructure of Rejuvenated Fe-Ni Based Superalloys
Authors: Srimark Kittawat , Wangyao Panyawat , Rojhirunsakool Tanaporn
Published: August 2020

Fe-Ni based superalloys have been widely used in land-base gas turbine application. The turbine blade was in service for 50,000 h at high temperature and stresses. When subjected to long-term exposure at high temperature, the microstructure lost its best mechanical properties due to the microstructural instability. The aim of this research is to understand the effect of cooling rate on gamma (γ) grain size and gamma prime (γ’) particle size, morphology, and its volume fraction in rejuvenated Fe-Ni based superalloys. The alloys were solutionized above the γ’ solvus temperature at 1125 °C for 2 h for homogenization and cooling to room temperature at different cooling rates. The alloys were experienced with furnace cooling, air cooling, oil quenching, and water quenching. Microstructural analyses were investigated. Grain size, morphology, volume fraction of γ’ precipitates were investigated. Preliminary mechanical properties such as microhardness was conducted.
The Effects of Austempering Temperature and Time on Mechanical Properties of Ductile Cast Iron Grade FCD450
Authors: Chantarach Janthira , Canyook Rungsinee
Published: August 2020

The purpose of the study was to inspect microstructure, mechanical properties and impact toughness of ductile cast iron grade FCD450 produced by austempering process. The study focused on austempering parameter, which effected impact toughness of material at low temperature. The FCD450 was initially temperature austenized at 885°C (1625˚F) for 2 hours. Austempering was carried out at three different temperatures of 271°C (520˚F), 313°C (560˚F) and 357°C (675˚F). The austempering temperature were varied at 1.5, 2.5 and 3.5 hours. X-ray diffraction was showed that the austempered ductile cast iron (ADI) microstructure consists of austenite and ferrite. The results showed that when austempered at 357°C (675˚F) for 2.5 hours has highest hardness and impact energy at low temperature. The dimple ductile fracture of ADI fracture surfaces was revealed by scanning electron microscope (SEM).
Fabrication and Characterization of PVDF/UiO-66(Zr) Mixed Matrix Membrane on Non-Woven PET Support
Authors: Cementina John Rhoel , Torres Michael V. , Bernabe Dante P. , Lirio Stephen , Ang Micah Belle Marie Yap , Caparanga Alvin R.
Published: August 2020

Polyvinylidene fluoride (PVDF) membranes, enhanced with metal-organic framework (MOF), were fabricated on a non-woven polyethylene terephthalate (PET) support using the non-solvent induced phase inversion (NIPS) method to produce mixed matrix membrane (MMM). Polymer concentration of 10%, 15%, and 20% were used in the study whereas UiO-66(Zr) was used as a MOF filler. The resulting membranes were characterized in terms of their morphology, porosity, wettability, mechanical strength, pure water flux, and gas permeability. Results show that the presence of UiO-66(Zr) filler improved membrane morphology, mechanical strength, and hydrophobicity of MMM as compared to pristine PVDF.
Application of Taguchi Methodology in Evaluating the Rockwell Hardness of SLA 3D Printed Polymers
Authors: Espino Michaela Tayag , Tuazon Brian Jumaquio , Robles Gerald Sanqui , Dizon John Ryan Cortez
Published: August 2020

Stereolithography (SLA) is an Additive Manufacturing technology which converts liquid resins to solid parts layer-by-layer by selectively curing the liquid resin using a (laser) light source. The mechanical properties SLA 3D printed parts are not yet determined or estimated before printing. Thus, this study aims to identify the optimum 3D printing configuration based on the indentation hardness properties of SLA-printed polymer parts. Taguchi approach was used in identifying the optimum 3D printing configuration wherein different factors were considered to meet the requirements of the orthogonal arrays. Five pieces of 3D printed test blocks with 9 indentation points on the surface were prepared for each factor. The tests followed ASTM D785 – 03 using Rockwell Scale B. The result for the optimum 3D printing configuration of SLA 3D printed material were concluded as the values with the highest Rockwell Hardness Number.
Effects of Minor Elements Additions to the Nanocrystalline FeAl Alloy Produced by Powder Metallurgy
Authors: Hamlati Zineb , Otmane Fadhéla , Mechri H. , Laslouni Warda , Azzaz Mohamed
Published: August 2020

Mechanical alloying has recently attracted considerable attention as researchers try to improve materials properties. The process can be performed at room temperature and homogeneous alloys can be produced. In this work Fe–28 wt. % Al; Fe–26 wt. % Al–2 wt. % Sn and Fe–26 wt. % Al–2 wt. % V alloys were synthesized by mechanical alloying to investigate the effects of tin and vanadium additions on the structural and microstructural properties of Nanocrystalline FeAl Alloy. Fe72Al28, Fe72Al26Sn2 and Fe72Al26Sn2 were ball milled for 30 h under argon atmosphere using a rotating speed of 200 rpm with 15 min pause time after every 15 min running time. The structural and microstructural properties of the ball milled powders were analyzed using X-ray diffraction (DRX) and Mössbauer spectroscopy techniques. The final powders are characterized by an average crystallite size of 10 nm for the Fe72Al28 alloy, 6 nm for the Fe72Al26Sn2 alloy and 19 nm for the Fe72Al26V2, accompanied by the introduction of a lattice strain of order of 1.55 %, 0.78 % and 0.80% respectively. The Mossbauer study of the Fe72Al26V2 samples showed doublet with isomer shift IS= 0.17 mm/s and three magnetically split sextet.
Shear Characteristics between FRP-Concrete Bonding Interface
Authors: Qian Bing , Zhang Lei , Ma Yue , Kong Xiang Li
Published: August 2020

At present, fiber reinforced composite materials (FRP) are widely used in the reinforcement of concrete structures. The bonding interface between FRP plates and concrete is the key part of the strengthening of concrete structures with FRP plates. The bonding performance directly determines the success or failure of structural reinforcement. Based on the self-developed test device, the development of FRP and concrete in direct shear debonding test specimens, with the aid of advanced digital image correlation DIC technology, accurate measurement of specimen strain distribution on the surface of the FRP plate, and the FRP plate surface strain along the plate long distribution rule and the bond strength of the specimens was well researched, it reveals that the stripping of FRP and concrete interface failure process, and provides technical guidance for the treatment of FRP-concrete bond interface in practical projects.
Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4+ T Cells
Authors: Liu Haiyin , Wilson Kayla R. , Schriek Patrick , Macri Christophe , Blum Annabelle B. , Francis Lauren , Heinlein Melanie , Nataraja Champa , Harris James , Jones Sarah A. , Gray Daniel H. D. , Villadangos Jose A. , Mintern Justine D.
Published: August 2020

MHC class II (MHC II) displays peptides at the cell surface, a process critical for CD4+ T cell development and priming. Ubiquitination is a mechanism that dictates surface MHC II with the attachment of a polyubiquitin chain to peptide-loaded MHC II, promoting its traffic away from the plasma membrane. In this study, we have examined how MHC II ubiquitination impacts the composition and function of both conventional CD4+ T cell and regulatory T cell (Treg) compartments. Responses were examined in two models of altered MHC II ubiquitination: MHCIIKRKI/KI mice that express a mutant MHC II unable to be ubiquitinated or mice that lack membrane-associated RING-CH 8 (MARCH8), the E3 ubiquitin ligase responsible for MHC II ubiquitination specifically in thymic epithelial cells. Conventional CD4+ T cell populations in thymus, blood, and spleen of MHCIIKRKI/KI and March8−/− mice were largely unaltered. In MLRs, March8−/−, but not MHCIIKRKI/KI, CD4+ T cells had reduced reactivity to both self– and allogeneic MHC II. Thymic Treg were significantly reduced in MHCIIKRKI/KI mice, but not March8−/− mice, whereas splenic Treg were unaffected. Neither scenario provoked autoimmunity, with no evidence of immunohistopathology and normal levels of autoantibody. In summary, MHC II ubiquitination in specific APC types does not have a major impact on the conventional CD4+ T cell compartment but is important for Treg development.
Posttransplant Cyclophosphamide and Antithymocyte Globulin versus Posttransplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis for Peripheral Blood Stem Cell Haploidentical Transplants: Comparison of T Cell and NK Effector Reconstitution
Authors: Makanga Dhon Roméo , Guillaume Thierry , Willem Catherine , Legrand Nolwenn , Gagne Katia , Cesbron Anne , Gendzekhadze Ketevan , Peterlin Pierre , Garnier Alice , Le Bourgeois Amandine , Béné Marie C. , Chevallier Patrice , Retière Christelle
Published: August 2020

A higher incidence of graft-versus-host disease (GVHD) has been observed after haploidentical hematopoietic stem cell transplantation (h-HSCT) with posttransplant cyclophosphamide (PTCY) using peripheral blood stem cells (PBSC) as a source of graft. Moreover, combining PTCY with antithymocyte globulin (ATG) may help to reduce GVHD incidence. In this study, early immune reconstitution, especially of T and NK cell compartments, was compared after both types of transplant (PTCY versus PTCY + ATG) investigate their influence on patient outcomes. This retrospective study included 58 adults who received a reduced intensity conditioning to PBSC h-HSCT with cyclosporine and mycophenolate mofetyl + PTCY (n = 32) or PTCY + ATG (n = 26) as GVHD prophylaxis. Both groups shared similar characteristics except for the median number of CD3+ T cells infused, significantly higher for PTCY + ATG patients. Blood samples from all patients were collected three times a week from day 0 until day 30 then at day 60 and day 90/100 to evaluate T and NK cells reconstitution by flow cytometry. The results show that PTCY + ATG versus PTCY alone significantly limits the occurrence of acute grade 2–4 GVHD after reduced intensity conditioning PBSC h-HSCT, perhaps because of the combined effect of T and NK cell reconstitution. Indeed, although a slower T cell reconstitution with PTCY + ATG may limit GVHD occurrence, the quicker reconstitution of some NK cell subtypes may help with avoiding relapse. Larger prospective studies are needed to better determine which NK cell subsets may influence the incidence of relapse after h-HSCT and optimize donor selection.
Prevalence of cryptococcal antigen (CrAg) among HIV-positive patients in Eswatini, 2014–2015
Authors: Haumba Samson M. , Toda Mitsuru , Jeffries Rossana , Ehrenkranz Peter , Pasipamire Munyaradzi , Ao Trong , Lukhele Nomthandazo , Mazibuko Sikhathele , Mkhontfo Mandzisi , Smith Rachel M. , Chiller Tom
Published: August 2020

Background: Cryptococcal meningitis is a leading cause of death amongst people living with HIV. However, routine cryptococcal antigen (CrAg) screening was not in the national guidelines in Eswatini.Objectives: A cross-sectional study was conducted between August 2014 and March 2015 to examine CrAg prevalence at Mbabane Government Hospital in Eswatini.Methods: We collected urine and whole blood from antiretroviral-therapy-naïve patients with HIV and a cluster of differentiation 4 (CD4) counts 200 cells/mm3 for plasma and urine CrAg lateral flow assay (LFA) screening at the national HIV reference laboratory. Two CD4 cut-off points were used to estimate CrAg prevalence: CD4 100 and 200 cells/mm3. Sensitivity and specificity of urine CrAg LFA was compared to plasma CrAg LFA.Results: Plasma CrAg prevalence was 4% (8/182, 95% confidence interval [CI]: 2–8) amongst patients with CD4 counts of 200 cells/mm3, and 8% (8/102, 95% CI: 3–15) amongst patients with CD4 counts of 100 cells/mm3. Urine CrAg LFA had a sensitivity of 100% (95% CI: 59–100) and a specificity of 80% (95% CI: 72–86) compared with plasma CrAg LFA tests for patients with CD4 200 cells/mm3. Forty-three per cent of 99 patients with CD4 100 were at World Health Organization clinical stages I or II.Conclusion: The prevalence of CrAg in Eswatini was higher than the current global estimate of 6% amongst HIV-positive people with CD4 100 cell/mm3, indicating the importance of initiating a national screening programme. Mechanisms for CrAg testing, training, reporting, and drug and commodity supply issues are important considerations before national implementation.
Detección de tendencias a la transgresión de normas en estudiantes adultos de una Unidad Educativa de Educación Primara en Ecuador
Authors: Durán-Solórzano Stéfano Alexander
Published: August 2020

Este trabajo de investigación buscó detectar las tendencias a la transgresión de normas basada en 14 muestras de adultos que estudian en el 10mo curso de educación primaria de la jornada nocturna en un colegio fiscal de la ciudad de Guayaquil – Ecuador. Se hizo énfasis en la teoría médico-psiquiátrica y en el psicoanálisis. El primer encuadre acuña el constructo de trastorno de la personalidad antisocial cuyas tendencias son: ser dramáticos; mantenimiento de relaciones interpersonales superficiales, además de conflictivas de modo superlativo; problemas con las normas morales o la ley. El siguiente encuadre fue el psicoanalítico que, desde el constructo de perversión, donde el sujeto goza poniendo como objeto al otro dentro de una relación asimétrica de poder. Se utilizó el Protocolo Invertido de Alertas Gráficas© para la detección de sujetos transgresores de normas en la evaluación grafológica donde se obtuvieron los siguientes resultados: invasión de espacio ajeno, problemas para acatar órdenes de la autoridad, estallidos de irritabilidad como respuesta a la baja tolerancia a situaciones frustrantes o estresoras, ideas confusas cuya consecuencia sea el tener comportamientos difíciles o complejos, abandonar las tareas si no obtienen resultados rápidos y no asumir la responsabilidad de los actos, delegándola a terceros.

Palabras clave: transgresión, normas, psiquiatría, psicoanálisis, grafología.
Cardiac Functions & Lipid Profile In Obese Children & Adolescents
Authors: T. Ajit Kumar  , Dr. Vineeta Pande  , Dr. Sharad Agarkhedkar  , Dr. Mayank Surana
Published: August 2020

Background: Obesity is a disease which results from genetic or lifestyle factors. Such diseases are called Non communicable diseases. The epidemic of obesity among youth is spreading at an alarming rate due to lack of physical activity, dietary habits. The percentage of youths who are at risk of becoming overweight continues to increase. National data indicates that 16% of children aged six to nineteen years are overweight.(1)   Considering the high prevalence of  obesity among children and adolescents and its associated cardiovascular complications like hypertension, left ventricular hypertrophy, increased left ventricular mass, decreased left ventricular ejection fraction, the present study was planned to assess cardiac functions and lipid profile in obese children and adolescents. Early detection and intervention can help in reducing the complications associated with obesity. Objective: Primary objective is to assess cardiac functions and lipid profile in obese children and adolescents. Methodology: 100 obese children and adolescents in the age group 6-18 years were taken after excluding obese children with evidence of endocrine disease, malformation syndromes and iatrogenic obesity (drug treatments). Results: In the present study 7% subjects were hypertensive while 8% were prehypertensive. 71.43% children with hypertension were performing physical activity for < 30 min in 1-3 days/week while 49.11% normotensive children were performing physical activity for > 30 min per day. 3% obese children were having abnormal LVEF on 2DECHO .All the 3 obese children with abnormal LVEF were having physical activity less than 30 min in 1-3 days /week and the difference was statistically significant. All the three children with abnormal LVEF were hypertensive and the difference was statistically significant. 6% children were having raised serum cholesterol >190mg/dl.   Serum triglyceride >150mg/dl was observed in 17% obese children. HDL level <20mg/dl was observed in 7% children while LDL above 130mg/dl was observed in 6% children. The proportion among male and female children was comparable. Conclusion: Cardiovascular complications of adulthood in obese children and adolescents may be prevented by early identification and intervention in the form of healthy life style, dietary intake and physical activity.
ANALISIS EFISIENSI USAHATANI STROBERI (Fragaria x ananassa) (Studi Kasus : Desa Dolat Rakyat Kecamatan Dolat Rakyat Kabupaten Karo)
Authors: Sinaga Asmina Herawaty , Laia Firman
Published: August 2020

The purpose of this study is (1) to analyze the amount of strawberry ushatani income, starting from production, selling price, revenue to net income, (2) analyzing the level of optimization of the use of inputs on strawberry farming, (3) knowing the feasibility of strawberry ushatani, is it worth the effort or not. The amount of income of a sample farmer is influenced by age, farming experience and the number of production factors used. The everage strawberry production in the study area is 1,077,915 kg with an average land area of 0,23 H. The income and income of sample farmers also have an importent effect on the selling price of production, where the everage selling price of farmers in the study area is quite large, namely Rp25,000 / kg. The everage acceptance of sample farmers in the study area is Rp26,947,875 with an average production cost of Rp21,292,126 so that it receives an average net income of Rp5,655,749/year. And this very low when compared to UMK Karo of Rp2,619,234.41. Strawberry farmers in the study area mostly have a fairly low aducation of 9 years, therefore farmers have minimal knowledge in cultivation and marketing techniques and also the lack of farmers in terns of farm management that does not take into account the supporting factors of farming and use more than one (1), sucs as pesatisida with the same function so that it will increase production costs, as well as low access to farmers’s capabilites in government and banking policies. 

Keywords : Optomization, Strawberry.
PENGARUH DISIPLIN KERJA TERHADAP KINERJA PEGAWAI NEGERI SIPIL (PNS) DI LINGKUNGAN AJUDAN JENDERAL DAERAH MILITER (AJENDAM) - I BUKITBARISAN MEDAN
Authors: Ichsan Reza Nurul , Surianta Eddi , Nasution Lukman
Published: August 2020

Disiplin Kerja adalah suatu hal yang penting untuk keberhasilan setiap organisasi, baik di pemerintahan maupun  organisasi/instansi swasta. Suatu organisasi ataupun instansi pemerintah akan berhasil dalam pencapaian tujuan bilamana setiap individu atau pegawainya menerapkan disiplin dalam bekerja. Dengan demikian kinerja setiap anggota atau pegawai akan meningkat yang sekaligus juga meningkatnya kinerja organisasi tersebut. Demikian juga halnya dengan Kantor Ajendam I/BB di Medan. Teori yang digunakan dalam penelitian ini adalah teori yang berhubungan dengan manajemen sumberdaya manusia terutama teori yang menyangkut tentang disiplin kerja dan kinerja pegawai, baik secara kuantitatif maupun secara kualitatif. Penelitian ini dilakukan di Ajendam I Bukit Barisan Medan yang berlokasi di Jalan Gatot Subroto Km 7.6. Medan. Kegiatan penelitian ini direncanakan akan dilakukan terhitung sejak bulan Mei hingga Juli 2017. Dari pembahasan yang dilakukan sesuai dengan topik dan pokok permasalahan, serta  analisis data yang dilakukan diperoleh hasil dalam bentuk regresi linier sederhana yaitu Y =  7,541 +  0, 413X   dengan determinansi sebesar 84,8%, dan secara umum disiplin kerja berpengaruh signifikan terhadap kinerja pegawai pada Kantor Ajendam I Bukit Barisan Medan, dimana t hitung sebesar 20,060 sedangkan t table 1,984 pada = 5%.  Dari hasil yang diperoleh disarankan kepada pimpinan Ajendam I Bukit Barisan Medan agar menjaga dan lebih meningkatkan serta membina disiplin kerja  pada lembaga tersebut, demi tercapainya peningkatan kinerja pegawai secara keseluruhan sesuai dengan harapan.
PENGARUH GOOD CORPORATE GOVERNANCE DAN UKURAN PERUSAHAAN TERHADAP PROFITABILITAS PADA PERBANKAN YANG TERDAFTAR DI BEI
Authors: Purba Rolita Christina
Published: August 2020

Perusahaan berupaya berjuang untuk bertahan hidup dengan cara menjalan fungsi manajemen masing-masing sehingga mencapai sasaran dan memperoleh laba. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh good corporate governance dan ukuran perusahaan terhadap profitabilitas pada Perbankan yang terdaftar di BEI. Populasi pada penelitian ini adalah Perbankan yang terdaftar pada Bursa Efek Indonesia (BEI) periode 2017 sampai dengan 2019 sebesar 43 Perbankan. Teknik pengambilan sampel pada penelitian ini dengan menggunakan sensus, dimana semua populasi dijadikan sampel peneltian dikalikan tahun pengamatan menjadi 129 observasi.
PEMBELAJARAN SANDI MORSE PRAMUKA DENGAN MENGGUNAKAN METODE USER CENTERED DESIGN
Authors: Azlan Azlan
Published: August 2020

Gerakan pramuka Indonesia merupakan wadah para generasi muda untuk mengembangkan minat, bakat, keterampilan dan kedisiplinan. Banyak kegiatan yang dilakukan dalam gerakan pramuka, selain kegiatan baris berbaris ada juga kegiatan dalam menghafal kode-kode pramuka yang dikenal dengan sandi. Sandi pramuka bermacam-macam diantaranya adalah sandi morse. Media pembelajaran yang digunakan kurang efektif yaitu berupa buku panduan buku saku atau buku syarat kecakapan umm (SKU) dengan tampilan yang kurang menarik dikarenakan buku tersebut hanya berwarna hitam, tidak adanya animasi, dan lain- lain yang menyebabkan kurangnya minat untuk mempelajarinya. Untuk menarik minat belajar tersebut dibuatlah media pembelajaran yang baru berupa aplikasi pembelajaran sandi morse pramuka berbasis komputer atau menggunakan komputer. Dalam tesis ini akan dibahas tentang cara membangun aplikasi pembelajaran sandi morse pramuka dengan metode ucer centered design. Aplikasi dibangun dengan bahasa pemrograman
macromedia flash 8.
PENGARUH PERBEDAAN GENDER TERHADAP PRESEPSI DAN KEPEMINATAN PEMAKAIAN PERANGKAT KOMPUTERISASI
Authors: Sari Yunita
Published: August 2020

The objective of this study is to investigate whether computer attitude influences
perceived usefulness. This study also investigates whether gender influence relation between perceived usefulness and behavioral intention. The subject is of this study is student from three private university or college of Kota Madya Batam, Kepulauan Riau. There are 150 respondents. The result of study support hypothesis of the study of that the computer attitude influence perceived usefulness. This study also support hypothesis that gender influence relation between perceived usefulness and behavioral intention.
SISTEM INFORMASI PENDATAAN SURAT MASUK DAN KELUAR CV. MEDIA KREATIF ONLINE
Authors: Tanjung Rona
Published: August 2020

Berdasarkan hasil analisis yang telah dilakukan di CV. Media Kreatif Online, bahwa sistem Pendataan Surat masuk dan surat keluar,masih melakukan sistem manual atau Tulisan Sehingga dalam proses pengelolahan data Surat Kelurahan mengalami kesulitan, yaitu tidak efisin, tidak akurat dan tidak cepat.

Pada tugas akhir ini penulis memilih judul “Sistem informasi pendataan surat masuk dan kemuar CV. Media Kreatif Online”. Adapun beberapa tahapan metode pengumpulan data yang digunakan yakni observasi, wawancara dan penelitian kepustakaan.Sistem informasi yang digunakan yakni sistem pemrograman visual basic 8.0 merupakan IDE (Integrated  Development Environment) yang digunakan untuk dikembangkan software dalam  IDE inilah yang tersedia berbagai fitur yang memudahkan pemrograman, seperti kompilasi, pengaturan projek, mengedit antar muka secara visual yang dirancang menjadi suatu sistem untuk mempermudah dan mempercepat proses pengolahan pendataan Surat masuk dan surat keluar

 

Kata Kunci: Sistem Informasi pendataan surat masuk dan surat keluar

 
ANALISIS SISTEM INFORMASI AKADEMIK MAHASISWA PADA STMIK GICI BATAM MENGGUNAKAN METODE PIECES
Authors: Yodi Yodi
Published: August 2020

Penelitian ini bertujuan untuk mengetahui sejauh mana tingkat kinerja, informasi, ekonomi, kontrol, efisiensi dan layanan yang ada pada website sistem informasi akademik mahasiswa STMIK GICI menggunakan metode PIECES. Hasil penelitian yang telah dilakukan adalah perlu peningkatan dan perbaikan dari sisi performance dan efficiency sedangkan dari sisi information, economic, control dan service sudah baik.