bluuebunny/crossref_metadata_2025 huggingface dataset:
PERTIMBANGAN HAKIM DALAM MEMUTUSKAN PERKARA DISPENSASI NIKAH BERDASARKAN ANALISIS MASLAHAH (Studi Penetapan Hakim No. 266/Pdt.P/2020/PA.Pwr di Pengadilan Agama Purworejo)
Authors: Sudarmaji Waluyo
Published: January 2022

In the event that the prospective bride and groom will hold a marriage registered at the local Office of Religious Affairs If the age is less than 19 years, it will be rejected because the marriage conditions are not fulfilled. Because the marriage is considered urgent to be carried out, then parents or guardians can apply for a marriage dispensation at the Religious Court. Marriage dispensation is an application for ratification of a marriage that will take place by the prospective bride and groom or one of the prospective brides who are not old enough to marry. This research is the result of research on the consideration of judges in deciding the case of marital dispensation with the analysis of maslahah with the main problem of consideration of judges in deciding the case and the analysis of maslahah. This research is analitive descriptive qualitative research with normative approach, data source used by primary data source in the form of interviews, observations, and secondary data in the form of court determination. The technical analysis of data used is qualitative approach to primary data and secondary data. The purpose of this research is what the judge considered in the Purworejo Religious Court in granting the application for marital dispensation on the determination No. 266/Pdt.P/2020/PA/Pwr, and to find out the determination of judges in the Purworejo Religious Court regarding marital dispensation which is analyzed through maslahah. Based on the results of the research conducted, it can be concluded that the consideration of the judge in granting the request for marital dispensation is on the grounds that the marriage is urgent to be done, between the husband and wife there is no obstacle to marriage and the two families have approved each other. In the analysis maslahah consideration of judges included in the maslahah doruriyah because to maintain religion and descendants.
WASIAT WAJIBAH KEPADA ANAK ANGKAT, NON MUSLIM DAN ANAK TIRI (FORMULASI HUKUM WASIAT WAJIBAH DALAM PASAL 209 KOMPILASI HUKUM ISLAM DI INDONESIA DAN PERKEMBANGANNYA)
Authors: Nofitasari Khotifatul Defi
Published: January 2022

Kompilasi Hukum Islam (KHI) di Indonesia memasukkan adanya wasiat wajibah bukan kepada cucu yang telah ditinggal mati orangtuanya dan terhijab oleh paman seperti halnya di negara-negara muslim lainnya. Wasiat wajibah yang diatur dalam pasal 209 ditujukan kepada anak angkat dan orang tua angkat. Perkembangan penerapan wasiat wajibah di Indonesia jauh berkembang melalui terobosan-terobosan hukum ijtihad hakim. Tidak hanya kepada anak dan orang tua angkat, wasiat wajibah di Indonesia juga diberikan kepada anak atau keluarga non muslim dengan adanya putusan tingkat kasasi yang menjadi rujukan. Dewasa ini, pembahasan lebih luas tentang objek pemberian wasiat wajibah di Indonesia kembali terjadi. Pembahasan tersebut berkenaan dengan adanya pemberian wasiat wajibah kepada anak tiri, walaupun hal tersebut masih menjadi pro dan kontra diantara para mujtahid dalam hal ini majelis hakim. Jenis penelitian ini adalah penelitian pustaka (library research) dengan metode analitis deskriptip analitik. Objek kajian penelitian ini adalah Pasal 209 Kompilasi Hukum Islam dan beberapa putusan wasiat wajibah kepada non muslim serta anak tiri. Penelitian ini menggunakan perspektif Normatif dan Sosiologis. Tujuan penelitian ini adalah untuk mengkaji lebih dalam formulasi hukum terhadap wasiat wajibah di Indonesia, baik pasal yang berlaku yaitu pasal 209 Kompilasi Hukum Islam, serta yurisprudensi wasiat wajibah dan perkembangan penerapannya.Kata kunci: Wasiat Wajibah, Formulasi Hukum, Kompilasi Hukum Islam
Perkembangan Kognitif, Fisik, Dan Emosi Sosial Pada Masa Prenatal
Authors: Hasanah Nurul Maziyatul , Fahmi A Dewi , Febri H Avita
Published: January 2022

Pendidikan anak dalam kandungan sangat penting karena pada saat itu anak mengalami perkembangan dan pertumbuhan awal yang baru. Selama di dalam kandungan, ibu merupakan orang terpenting dalam kecerdasan anak melalui pendidikan yang diberikan. Kondisi kesehatan ibu juga sangat mempengaruhi kondisi bayi. Banyak kondisi anak setelah lahir mengalami gangguan kesehatan karena pada saat anak dalam kandungan, ibu dan orang di sekitar anak mengabaikan kondisi kesehatan ibu dan kandungannya serta tidak memberikan pendidikan kepada anak di dalam kandungan. Upaya orang-orang di sekitar calon bayi sangat berpengaruh dan penting. Sehingga pendidikan prenatal atau pendidikan di dalam kandungan yang perlu dilakukan oleh keluarga dan orang disekitarnya.
Penggunaan Media Jarimatika Untuk Meningkatkan Kemampuan Berhitung Anak Usia Dini
Authors: Laela Nur , Suyadi Suyadi
Published: January 2022

Pemberian perhatian lebih pada anak usia dini merupakan salah satu bentuk perhatian, termasuk memberikan pendidikan baik secara langsung maupun melalui lembaga pendidikan anak usia dini. Setiap anak memiliki aspek perkembangan yang berbeda-beda, beberapa aspek yang harus dicapai antara nilai-nilai agama dan moral, keterampilan motorik fisik, kognitif, sosial emosional, bahasa dan seni, aspek perkembangan yang akan dibahas dalam penelitian ini adalah aspek kognitif . pengembangan. Efektivitas hasil selanjutnya dalam penggunaan alat edukasi Jarimatika telah diterapkan dengan baik sesuai pengamatan langsung dan dapat dikatakan “terlaksana”. Hasil penggunaan alat bermain edukasi Jarimatika untuk meningkatkan keterampilan berhitung anak usia dini diperoleh selama penelitian,
Analisis Rumusan Visi, Misi, Dan Tujuan Pendidikan Anak Usia Dini di TK II Pertiwi
Authors: Zulfania Safira
Published: January 2022

This research wanted to know the planning of the management of the vision, mission, and goals of the school in TK II Pertiwi Semarang. Choosing this kindergarten because the school institution has the appropriate vision, mission and goals. This research is descriptive research, namely research defines how the management of the vision, mission, and goals of TK II Pertiwi Semarang. The data obtained using qualitative research, data collection techniques can be done through observation and interviews. In preparing the vision and mission, it involves elements of the surrounding community and the management of related institutions. Pertiwi Kindergarten II School based on the vision, mission and objectives already includes the existing criteria. There needs to be an evaluation if there is anything that needs to be improved.
Supervisi Akademik Internal Guru TK Dengan Pendekatan Kolaboratif
Authors: Windarta Libri Rizka Puri
Published: January 2022

The principals have their own authority to carry out internal supervision and choose the type of approach used in schools according to the characteristics of the institution. The benefits of internal academic supervision are to improve teacher professional competence and teacher techniques in the learning process. The research was conducted at ABA Sumberadi Kindergarten which has 7 teachers, conducted in December. The purpose of this research is to get a real picture of institutions that use a collaborative approach in academic supervision. This type of research is qualitative, research subjects are principals and teachers. Techniques for collecting interview data and documents, interviews were conducted directly by the principal and teachers by meeting at school. The research data analysis technique used descriptive qualitative analysis techniques by analyzing the data obtained from interviews and then processed and presented with narration. The findings of this study are the collaborative approach is the approach chosen by schools because it is considered more effective for institutional improvement and principals are more flexible in exploring obstacles that arise in the learning process.
Pengenalan Permainan Warna Melalui Konsep Senyawa Polar dan Non Polar
Authors: Nazarullail Fikri , Rendy Dwi Bagus
Published: January 2022

Introduction to Color Games Through the Concept of Polar and Non Polar Compounds. This research was conducted to provide a new learning experience by adapting the concept of color recognition combined with simple science (polar and non polar). This study uses quantitative research approach with one-shot case study type. The results of a simple experimental process conducted in the learning process get positive data that is 88% or 15 children get a very good score and 12% or 2 children get a good score. Based on these results, similar activities can be carried out to introduce children to the concept of mixing colors adapting simple science in learning activities.
Keefektivan Pembelajaran Secara Online Terhadap Perkembangan Fisik Motorik Anak
Authors: Wahyuni Sri
Published: January 2022

The problem in this research is that in the online learning process the teachercannot monitor the physical development of the child's motor skills, because children studyat home and at home, the children cannot freely leave the house to play or go recreation.As a result, many parents think that playing cellphones is the main solution. The purposeof this study was to determine the effectiveness of online learning on motoric physicaldevelopment. The benefits of this research are expected to provide insight, boththeoretically and practically, for researchers in accordance with the focus of the researchbeing carried out. This research is a descriptive study, while the research information is asource of reference as well as previous research. Data collection was carried out by meansof observation, interview and documentation techniques. The instrument used by theresearcher was a physical motor indicator. Data analysts use an interactive analysis modelby collecting data, reducing data, presenting data, and drawing conclusions. The results ofresearch on children's physical motor development during online learning have decreased.
Caracterização do suicídio nos cinco municípios com as maiores taxas em Mato Grosso do Sul no triênio de 2014 – 2016
Authors: Silva Pedro , Mota Adeir
Published: January 2022

O presente estudo buscou caracterizar e analisar as taxas de mortalidade por suicídio nos cinco municípios com as maiores incidências em Mato Grosso do Sul, no triênio de 2014 a 2016. Os municípios de Tacuru, Japorã, Amambai, Paranhos e Novo Horizonte do Sul juntos tiveram 87 suicídios no período enquanto em todo o estado nesse mesmo período ocorreram 657. Esse estudo teve uma abordagem quantitativa a partir de dados disponibilizados no sistema de informação de mortalidade no SIM/DATASUS, do Ministério da Saúde e de dados sociodemográficos do IBGE. Com um banco de dados geográfico consolidado pode-se antes de tudo espacializar o suicídio em Mato Grosso do Sul e delimitar esses cinco municípios para caracteriza-lo e analisa-los a partir da literatura.
A Novel Integrated Learning Model for Rainfall Prediction CEEMD- FCMSE -Stacking
Authors: Zhang Xianqi , Wang Kai , Wang Tao
Published: January 2022

Scientific prediction of precipitation changes has important guiding value and significance for revealing regional spatial and temporal patterns of precipitation changes, flood climate prediction, etc. Based on the fact that CEEMD can effectively overcome the interference of modal aliasing and white noise, fine composite multi-scale entropy can reorganize the same FCMSE value to reduce the modal component and improve the computational efficiency, and Stacking ensemble learning can effectively and conveniently improve the fitting effect of machine learning, a rainfall prediction method based on CEEMD-fine composite multi-scale entropy and Stacking ensemble learning is constructed, and it is applied to the prediction of monthly precipitation in the Xixia. The results show that, under the same conditions, the CEEMD-RCMSE-Stacking model reduces the root mean square error by 83.48% and 62.08%, and the mean absolute error by 83.25% and 61.84%, respectively, compared with the single Stacking model and CEEMD-LSTM, while the goodness-of-fit coefficients improve by 15.94% and 2.34%, respectively, which means that the CEEMD-RCMSE-Stacking model has higher prediction performance. The CEEMD-RCMSE-Stacking model has higher prediction performance.
Prediction of Boundary Shear Stress Distribution in Converging Compound Channel Using Gene Expression Programming
Authors: Naik Bandita , Kaushik Vijay , Kumar Munendra
Published: January 2022

The computation of the boundary shear stress distribution in an open channel flow is required for a variety of applications, including the flow resistance relationship and the construction of stable channels. The river breaches the main channel and spills across the floodplain during overbank flow conditions on both sides. Due to the momentum shift between the primary channel and adjacent floodplains, the flow structure in such compound channels becomes complicated. This has a profound impact on the shear stress distribution in the floodplain and main channel subsections. In addition, agriculture and development activities have occurred in floodplain parts of a river system. As a consequence, the geometry of the floodplain changes over the length of the flow, resulting in a converging compound channel. Traditional formulas, which rely heavily on empirical approaches, are ineffective in predicting shear force distribution with high precision. As a result, innovative and precise approaches are still in great demand. The boundary shear force carried by floodplains is estimated by gene expression programming (GEP) in this paper. In terms of non-dimensional geometric and flow variables, a novel equation is constructed to forecast boundary shear force distribution. The proposed GEP-based method is found to be best when compared to conventional methods. The findings indicate that the predicted percentage shear force carried by floodplains determined using GEP is in good agreement with the experimental data compared to the conventional formulas (R2 = 0.96 and RMSE = 3.395 for the training data and R2 = 0.95 and RMSE = 4.022 for the testing data).
Investigation of the Reaction Path from UO2 to UF6 using Density-functional Theory
Authors: Wei Junkui , Bao Run-jia , Li Bo-wen
Published: January 2022

A detailed investigation of the reaction mechanism for UO2 reacting with F2 to form UF6 is performed by using density functional theory (DFT). We divide the whole reaction chain into four main steps, UO2+F2→UO2F2, UO2F2+F2→UO2F4, UO2F4→UF4+O2and UF4+F2→UF6. Contrary to what has been mostly expected that F2 molecule should directly replace two O atoms in UO2 molecule, two F2atoms actually combine with UO2 successively in the first two steps. The third step is relatively complex and one F atom in UO2F4 molecule plays a key role of carrying an O atomclose to the other O atom. In last step, F-F bond in F2 molecule fractures and two F atoms are bonding with U atom in UF4 molecule successively. Spin-flip appears in two elementary reactions owing to the existence of heavy atom U.
Microfibrillated Cellulose-silver Nanocomposite Based PVA Hydrogels and Their Enhanced Physical, Mechanical and Antibacterial Properties
Authors: Alam Md. Shamsul , Hasan Md. Sabbir , Foisal Jannat Al , Khan G. M. Arifuzzaman , Jahan Rownok , Hasanuzzaman Md. , Karim M. Minnatul , Gafur M. A. , Khan Muhammad Angkan , Sabur Md. Abdus
Published: January 2022

Modification of cellulose with silver nanoparticles produces various nanocomposites with significantly developed properties. This work aims to prepare a PVA hydrogel modified with cellulose/silver nanocomposites having potential applications in various fields including biomedical, antimicrobial inhibition, textile wears, etc. Microfibrillated cellulose/silver nanocomposites hydrogels were prepared in the aqueous medium with aid of microwave-assisted heating. Different percentages of nanocomposites were incorporated in PVA hydrogel to enhance the properties of PVA hydrogel. Prepared products were characterized by UV-Visible spectroscopy, FTIR, TGA, XRD, and SEM. The swelling (in water saline, acidic and alkaline solution), tensile, thermal, and antibacterial properties were also examined. The formation of Ag nanoparticles (AgNPs) in the (MFC-Ag) NC was confirmed by XRD and UV–Vis spectra. UV–Vis spectra showed the characteristic peaks of Ag in the UV–Vis spectra at 425 nm. Final products exhibited significant porosity and maximum swelling of 519.44%. The thermal stability of hydrogel increased with an increased percentage of (MFC-Ag)NC. Hydrogels exhibited significant antimicrobial inhibition against multidrug-resistant microorganisms, including Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.
Nutritional Evaluation of Crambe Meal as a Partial Replacement of Soybean Meal in Nile Tilapia Diets
Authors: Hisano Hamilton , de Pietro Pamela Souza , Ishikawa Márcia Mayumi , Cardoso Alex Júnio da Silva , Arena Arielle Cristina
Published: January 2022

This study evaluated the apparent digestibility coefficient (ADC) of crambe meal (CM) and its potential to partially replace soybean meal (SM) protein in Nile tilapia diets. The ADC for dry matter, crude protein, ether extract, energy, amino acids, calcium and phosphorus of CM were assessed in fish (n=80; 65.30 ± 5.32 g). Subsequently, an 80-day feeding trial was conducted with Nile tilapia (n=140; 6.04 ± 0.25 g) randomly distributed in 20 experimental cages (70 L; seven fish cage-1) allocated in five circular tanks (1000 L) in recirculation water system, to evaluate the effects of replacement of SM by CM (0, 6, 12, 18 and 24% in isonitrogenous and isoenergetic diets) on growth, blood parameters, fillet yield and proximal composition. The CM shows good digestibility of protein (0.824) and amino acids (0.844) by Nile tilapia and its inclusion in the diet does not affect carcass and fillet yield or proximal composition. Fish fed diets with 24.0% of the SM replaced by CM showed the worst weight gain and feed conversion rate. The protein efficiency ratio decreased in fish fed diets with 12.0, 18.0 and 24.0% of the SM replaced by CM. Hemoglobin, mean corpuscular hemoglobin concentration, total plasma protein, glucose and alanine aminotransferase enzyme activity trend to increase at highest levels of CM in the diet. In conclusion, CM has potential to replace SM in Nile tilapia diets, due to high digestibility of protein and amino acids. However, anti-nutritional factors present in untreated CM interfere on the growth and nutrient utilization of Nile tilapia.
Systemic HER3 ligand-mimicking bioparticles cross the blood–brain barrier reducing intracranial triple-negative breast cancer growth
Authors: Alonso-Valenteen Felix , Sances Sam , Wang HongQiang , Mikhael Simoun , Sims Jessica , Taguiam Michael , Srini Dustin , Sanchez Romny , Serrano Erik , Ondatje Briana , Teh James , Wong Michelle , Nguyenle Kimngan , Miao Tianxin , Benhaghnazar Rebecca , Yu John , Svendsen Clive , Abrol Ravinder , Kauwe Lali Medina
Published: January 2022

Triple-negative breast cancer (TNBC) lacks selective biomarkers targeted by current clinical therapies and often metastasizes to the brain. Crossing the blood-brain barrier (BBB) and reaching intracranial tumors is a clinical challenge contributing to poor prognoses for patients. The human epidermal growth factor receptor HER3 has emerged as a biomarker of metastasis and may provide a means of therapeutically targeting TNBC. We have developed HER3-targeted biological particles (bioparticles) that exhibit systemic homing to resistant and metastatic breast tumors. Here we show that HER3 is expressed on the brain endothelium and can mediate the passage of bioparticles across the BBB and into intracranial TNBC. Our findings show that the extravasation of systemic bioparticles in mice and in human induced pluripotent stem cell-based BBB chips corresponds to HER3 levels. Furthermore, systemically delivered bioparticles carrying tumoricidal agents reduced the growth of intracranial TNBC in mice and exhibited improved therapeutic profile compared to current therapies.
Assessing the Sustainability Index of Part-Time and Full-time Hazelnut Farms in Giresun and Ordu Province, Turkey
Authors: YILDIRIM Çağatay , Türkten Hatice , BOZ İsmet
Published: January 2022

The study's primary purposes were to assess the sustainability index of hazelnut farms and explore the effects of part-time and full-time farming types on sustainability index in hazelnut production in the Giresun and Ordu Province of Turkey. One hundred fifty-two hazelnut farms were selected using the stratified sampling method, and data were collected. Several steps were taken, including using factor analysis after standardizing the variables to determine their weights to calculate the composite hazelnut farms sustainability index. The research findings showed that overall hazelnut sustainability scores of farms varied from 0.28 to 0.59, and the average score was 0.44 at sampled farms. The composite hazelnut sustainability index was at an unsatisfactory level. The social and economic sustainability index value of farms was equal, and they were higher than the environmental index value. The values were 0.50 and 0.30, respectively. While the economic sustainability index score of full-time farms was higher than that of part-time farms, and part-time farms had higher environmental sustainability index scores than that of full-time farms. Social sustainability scores were not different in terms of farm type. It was recommended that when designing and regulation support policies, policy-makers should differentiate part-time and full-time hazelnut farming. Training and extension programs must be planned to increase the level of knowledge of every willing farmer. In addition, training and certification programs must be implemented to enhance the quality of the foreign labor force.
Proposing Several Model Techniques Including ANN and M5P-tree to Forecast the Stress at the Failure of Geopolymer Concrete Mixtures Incorporated Nano-silica
Authors: Ahmed Hemn Unis , Mohammed Ahmed S. , Mohammed Azad A.
Published: January 2022

Geopolymers are innovative cementitious materials that can completely replace traditional Portland cement composites and have a lower carbon footprint than Portland cement. Recent efforts have been made to incorporate various nanomaterials, most notably nano-silica (nS), into geopolymer concrete (GPC) to improve the composite's properties and performance. Compression strength (CS) is one of the essential properties of all types of concrete composites, including geopolymer concrete. As a result, creating a credible model for forecasting concrete CS is critical for saving time, energy, and money, as well as providing guidance for scheduling the construction process and removing formworks. This paper presents a large amount of mixed design data correlated to mechanical strength using empirical correlations and neural networks. Several models, including artificial neural network, M5P-tree, linear regression, nonlinear regression, and multilogistic regression models were utilized to create models for forecasting the CS of GPC incorporated nS. In this case, about 207 tested CS values were collected from literature studies and then analyzed to promote the models. For the first time, eleven effective variables were employed as input model parameters during the modeling process, including the alkaline solution to binder ratio, binder content, fine and coarse aggregate content, NaOH and Na2SiO3 content, Na2SiO3/NaOH ratio, molarity, nS content, curing temperatures, and ages. The developed models were assessed using different statistical tools such as RMSE, MAE, SI, OBJ value, and R2. Results revealed that the ANN model estimated the CS of GPC incorporated nS more accurately than the other models. On the other hand, the alkaline solution to binder ratio, molarity, NaOH content, curing temperature, and ages were those parameters that have significant influences on the CS of GPC incorporated nS.
Translation and Validation of M.D. Anderson Symptom Inventory-Thyroid Cancer Module in Chinese Thyroid Cancer Patients: A Cross-Sectional and Methodological Study
Authors: Hu Ziyi , Gou Juxiang , Cai Ming , Zhang Yueer
Published: January 2022

Aim

To translate and validate the Chinese version of the MDASI-THY among thyroid cancer patients.
Background

The M.D. Anderson Symptom Inventory-Thyroid Cancer module (MDASI-THY) is one of well-validated instruments for thyroid-specific symptom assessment. To date, the instrument has not been used in China.
Methods

After standard forward- and back-translation procedures, two instruments, the Chinese version of MDASI-THY and the European Organization for Research and Treatment of Cancer QLQ C30, were answered by 309 thyroid patients. The content, convergent discriminant validity and reliability of the MDASI-THY were evaluated. The Standards for Reporting Diagnostic Accuracy Studies (STARD) was used as reporting checklist.
Results

S-CVI and I-CVI of the instrument were over 0.80. There were significant relationships between MDASI-THY and EORTC QLQ-C30 (p<0.001). Symptoms were severer for patients underwent surgical treatment. The Cronbach’s alpha was 0.966 (between 0.954 and 0.827 for subscales). Most symptom items had moderate to high interitem correlations.
Conclusions

The Chinese version of MDASI-THY demonstrated favorable validity and reliability. It can be used in development of symptom management program in thyroid cancer patients in China.
Relevance to clinical practice:

Nurse can apply this instrument to assess Chinese thyroid cancer patients to increase the understanding of their symptom experience, resulting in a better symptom management.
Pharmacokinetic Parameter Driven Outcomes Model Predicts a Reduction in Bleeding Events Associated with BAY 81-8973 Versus Antihemophilic Factor (Recombinant) Plasma/Albumin- Free Method in a Chinese Healthcare Setting
Authors: Chen Rong , Gultyaev Dmitry , Lister Johanna , Han Rong , Hu Nan , Malacan Jean , Solms Alexander , Vashi Parth , O’Hara Jamie , Hu Shanlian
Published: January 2022

Background: Long-term prophylactic therapy is considered the standard of care for hemophilia A patients. This study models the long-term clinical and cost outcomes of two factor VIII (FVIII) products using a pharmacokinetic (PK) simulation model in a Chinese population. Methods: Head-to-head PK profile data of BAY 81-8973 (KOVALTRY®) and antihemophilic factor (recombinant) plasma/albumin-free method (rAHF-PFM, ADVATE®) were applied to a two-state (alive and dead) Markov model to simulate blood FVIII concentrations at a steady state in prophylactically-treated patients with hemophilia A. Worsening of the Pettersson score was simulated and decline was associated with the probability of having orthopaedic surgery. The only difference between the compounds was FVIII concentration at a given time; each subject was treated with 25 IU/kg every 3 days. The model used a lifetime horizon, with cycle lengths of 1 year. Results: Cumulative bleeding events, joint bleeding events, and major bleeding events were reduced by 19.3%, 9.3% and 19.3%, respectively for BAY 81-8973 compared to rAHF-PFM. Hospitalizations and hospitalization days were also reduced by 19.3% for BAY 81-8973 compared to rAHF-PFM. BAY 81-8973 resulted in both cost savings and a gain in quality adjusted life years (QALYs) compared to rAHF-PFM. Conclusion: Based on modeled head-to-head comparisons, differences in PK-properties between BAY 81-8973 and rAHF-PFM result in a reduced number of bleeding events, leading to reduced costs and increased quality of life for BAY 81-8973. These results should be used to inform clinical practice in China when caring for patients with severe hemophilia A.
Associations of maternal plasma and infant umbilical cord blood plasma metabolomics profiles with anthropometric measures at birth: a prospective cohort study.
Authors: Yeum Dabin , Gilbert-Diamond Diane , Doherty Brett , Coker Modupe , Stewart Delisha , Kirchner David , McRitchie Susan , Sumner Susan , Karagas Margaret , Hoen Anne
Published: January 2022

BackgroundThe metabolomics profiles of maternal plasma during pregnancy and cord plasma at birth might influence fetal growth and birth anthropometry. The objectives of this study are to examine how metabolites measured in maternal plasma samples collected during pregnancy and umbilical cord plasma samples collected at birth are associated with newborn anthropometric measures, a known predictor of future health outcomes.MethodsPregnant women between 24 and 28 weeks of gestation were recruited from prenatal clinics in New Hampshire as part of a prospective cohort study. Blood samples from 413 women at enrollment and 787 infant cord blood samples were analyzed using the Biocrates AbsoluteIDQ® p180 kit . Multivariable linear regression models were used to examine association of cord and maternal metabolites with infant anthropometry at birth.ResultsIn cord blood samples, several acylcarnitines, a phosphatidylcholine, and a custom metabolite indicator were negatively associated with birth weight Z-score, and lysophosphatidylcholines as well as three custom metabolite indicators were positively associated with birth weight Z-score. Acylcarnitine C5 was negatively associated with birth length Z-score, and several lysophosphatidylcholines and a custom metabolite indicator were positively associated with birth length Z-score. Maternal blood metabolites did not show significant associations with birth weight and length Z scores, however, a custom metabolite indicator, the ratio of kynurenine over tryptophan, was negatively associated with weight-for-length Z-score.ConclusionsSeveral cord blood metabolites associated with newborn weight and length Z-scores; in particular, consistent findings were observed for several acylcarnitines that play a role in utilization of energy sources, and a lysophosphatidylcholine that is part of oxidative stress and inflammatory response pathways. Fewer associations were observed with maternal metabolomic profiles.
The Trend of Dental Check-Up And Incidence of Dental Complications Following The Use of Bone Modifying Agents In Patients With Metastatic Breast And Prostate Cancer: Analysis of Data From The Korean National Health Insurance Service
Authors: Lim Ah Reum , Park Wonse , Moon Seok Joo , Kim Min Sun , Lee Soohyeon
Published: January 2022

Purpose: Bone-modifying agents (BMAs) are key components in the management of cancer patients with bone metastasis. Despite their clinical benefits, the use of BMAs is associated with adverse dental events including medication-related osteonecrosis of the jaw (MRONJ). This study investigated the rate of preoperative dental surveillance to reduce the incidence of adverse dental events including MRONJ after BMA treatment in patients with bone metastasis from breast and prostate cancer. Methods: Data, including age, cancer diagnosis, administered BMAs, and adverse dental events during cancer treatment, of patients with bone metastasis from breast and prostate cancer who received at least one infusion of BMA between 2007 and 2019 were extracted from the Korean National Health Insurance Service (KNHIS) dataset. Results: Of the 15357 patients who received BMAs, 1706 patients (11.1%) underwent dental check-ups before BMA treatment. The proportion of patients receiving dental check-ups increased from 4.4% in 2007 to 16.7% in 2019. Referral for dental check-up was more frequent in clinics and primary hospitals than in tertiary hospitals, and from the departments of internal medicine and urology than from the department of general surgery, regardless of the patient's health insurance status. After BMA treatment, 3328 patients (21.6%) developed adverse dental events, including tooth extraction (73.0%), abscess (16.9%), acute periodontitis (5.3%), acute pericoronitis (2.6%), and MRONJ (2.2% of 3328, 0.5% of 15357). Conclusions: Considering the long treatment period in patients with metastatic cancer, coordination between dentists and oncologists is necessary to ensure appropriate dental treatment before the initiation of BMAs.
Visual Outcomes of Macula-Involving Rhegmatogenous Retinal Detachment in Patients with and Without Age-Related Macular Degeneration
Authors: Paulk P. Barrett , Eloubeidi Dala , III John O. Mason , Curcio Christine A. , Crosson Jason N. , Johnson Mark , Swain Thomas
Published: January 2022

Background

Patients presenting with macula-off rhegmatogenous retinal detachment (RRD) with concomitant age-related macular degeneration (AMD) and their treating physicians would benefit from knowledge regarding the visual prognosis after repair. The prognosis for such patients is not well known. The purpose of this study is to compare visual outcomes in macula-off RRD in eyes with AMD versus a group of comparison eyes without AMD.
Methods

This was a retrospective chart review of 1,149 patients. A total of 191 eyes met study criteria, 162 non-AMD eyes (controls) and 29 AMD eyes. The main outcome measure was postoperative visual acuity in control eyes versus AMD eyes, and this was compared using Fisher’s exact test.
Results

There was a statistically significant difference in postoperative visual acuity by AMD status, with those without AMD having a higher frequency of Count Fingers (CF), Hand Motion (HM), Light Perception (LP), or No Light Perception (NLP) vision (p = 0.023). More specifically 5.56% of non-AMD eyes and 3.45% of AMD eyes were 20/40 or better, 77.16% of non-AMD and 55.17% of AMD eyes were worse than 20/40 and better than 20/200, 10.49% of non-AMD eyes and 37.93% of AMD eyes were 20/200 or worse, and there were 11 eyes in the non-AMD group with CF, HM, LP, or NLP vision while there was only 1 eye in the AMD group with CF vision.
Conclusions

Though postoperative visual acuity was worse in the non-AMD group with a higher frequency of patients having final vision of CF, HM, LP, or NLP, this is not likely a clinically significant finding. Rather, it is a function of the difference in sample size and composition between the two groups. Importantly, this study suggests AMD patients can expect similar outcomes to non-AMD patients after RRD repair. Our study suggests that approximately 58% of patients with AMD can expect to maintain functional vision better than 20/200. We conclude that AMD patients can achieve functional vision after RRD surgery, similar to those without AMD. These findings may be helpful in guiding realistic expectations of AMD patients with RRD.
A hybrid integrated dual-microcomb source
Authors: Dmitriev Nikita , Koptyaev Sergey , Voloshin Andrey , Kondratiev Nikita , Lobanov Valery , Min'kov Kirill , Riabko Maksim , Polonsky Stanislav , Bilenko Igor
Published: January 2022

Dual-comb interferometry is based on self-heterodyning two optical frequency combs, with corresponding mapping of the optical spectrum into the radio-frequency domain. The dual-comb enables diverse applications, including metrology, fast high-precision spectroscopy with high signal-to-noise ratio, distance ranging, and coherent optical communications. However, current dual-frequency-comb systems are designed for research applications and typically rely on scientific equipment and bulky mode-locked lasers. Here we demonstrate for the first time a fully integrated power-efficient dual-microcomb source that is electrically driven and allows turnkey operation. Our implementation uses commercially available components, including distributed-feedback and Fabry--Perot laser diodes, and silicon nitride photonic circuits with microresonators fabricated in commercial multi-project wafer runs. Our devices are therefore unique in terms of size, weight, power consumption, and cost. Laser-diode self-injection locking relaxes the requirements on microresonator spectral purity and Q-factor, so that we can generate soliton microcombs resilient to thermal frequency drift and with pump-to-comb sideband efficiency of up to 40% at mW power levels. We demonstrate down-conversion of the optical spectrum from 1400 nm to 1700 nm into the radio-frequency domain, which is valuable for fast wide-band Fourier spectroscopy, which was previously not available with chip-scale devices. Our findings pave the way for further integration of miniature microcomb-based sensors and devices for high-volume applications, thus opening up the prospect of innovative products that redefine the market of industrial and consumer mobile and wearable devices and sensors.
Assessment of faecal contamination in selected concrete and earthen ponds stocked with Clarias gariepinus
Authors: OLALEMI ADEWALE OLUWASOGO , OLUYEMI OLUWABUSAYOMI MARY , BAYODE MICHAEL TOSIN
Published: January 2022

Background

This study was carried out to monitor the levels of faecal pollution markers in catfish (Clarias gariepinus) and their growing waters in selected earthen and concrete ponds. Water and catfish samples were collected weekly in the months of February, March, April, May, June and July, 2019. The concentrations of enteric bacteria in the water and catfish samples were determined using membrane filtration and pour plate methods, respectively. The rate of bioaccumulation of faecal indicator bacteria was obtained by dividing the log concentration of each organism in catfish by the corresponding log concentration in the growing waters.
Result

The concentration of faecal coliforms in catfish samples from concrete and earthen ponds ranged from 1.41 to 2.28 log10 CFU/100 ml and 1.3 to 2.47 log10 CFU/100 ml respectively and in growing waters from the concrete and earthen ponds; 1.43 to 2.41 log10 CFU/100 ml and 1.50 to 2.80 log10 CFU/100 ml respectively. Faecal coliforms exhibited positive relationships with alkalinity in water samples from the earthen (r = 0.61) and concrete ponds (r = 0.62). Salmonella and faecal coliforms had the highest and least bioaccumulation in catfish raised in earthen pond, respectively, whereas Salmonella and enterococci had the highest and least bioaccumulation in catfish raised in concrete pond, respectively. Faecal coliforms and E. coli had the highest and least counts in water samples from the earthen pond during the dry and wet months, Salmonella and E. coli had the highest and least counts in water samples from the concrete pond during the dry and wet months.
Conclusion

There were high levels of bacterial faecal pollution markers in water and C. gariepinus from the earthen and concrete ponds. Physicochemical characteristics of the water and seasonality played major roles in the rate of bioaccumulation of the faecal pollution markers in C. gariepinus raised in the earthen and concrete ponds.
Us and Mri Neurography Assessment of Diagnostic Criteria in Patients With Carpal Tunnel Syndrome Using Electrophysiological Tests as Gold Standard: A Prospective Study
Authors: AlKaphoury Mona Gamalludin , Dola Eman Farouk
Published: January 2022

BackgroundPeripheral neuropathy evaluation depends mainly on physical examination, patient history, electrophysiological studies, with evoked potential abnormalities. High-resolution US has the advantage of being fast, non-invasive modality with nerve dynamic assessment allowing examination of long part of nerve. MR imaging serve better in examination of deeper nerves with higher contrast resolution. It shows great benefit in patient with atypical presentation, Equivocal diagnosis and suspicious of secondary cause and post-surgical relapse.MethodsThis study was conducted prospectively on 32 patients, presented with carpal tunnel syndrome diagnosed by electrophysiological tests. Superficial US of the wrist joint was done to all participants followed by MRI within 1 weeks of the US.We aimed to assess the measurements & criteria of both US & MRN in diagnosis of CTS, depending mainly on the three-measurement assessed by Buchberger et al., then to find the agreement between US & MR Neurography (MRN)ResultsUs proved to have higher rate of CTS prediction, the three main parameters CSA measurement, distal nerve flattening and flexor retinaculum bowing indices showed positive occurrence of 93.7%,59.4% &59.4% respectively. While we found that decreased nerve echotexture was positive in 90.6% of patients.Regarding MRI it showed less diagnostic ability when using CSA measurement as it was positive in 81.2% of patients, also distal tunnel nerve increased flattening and bowed flexor retinaculum positive results were slightly decreased to 56.2% for each. In contrast to high T2 signal of median nerve which was positive in 90.6% of patients.In agreement study, we found statically significant difference supporting US as the primary diagnostic modality of CTS depending mainly on the three measurement CSA, Flattening and bowing indices. Yet, for cases of secondary CTS and detection of underlying entrapping cause as well as innervated muscle early abnormality detection and better tissue characterization, MRI was better diagnostic modality with statistically significant difference. ConclusionsOur results proved that ultrasound examination can be used as first imaging modality after physician evaluation with comparable results to electrophysiological studies in evaluating CTS and try to find the cause. MRN examination came as second step in patients with suspected muscle denervation changes that could not be elicited by US or equivocal cases for detection of secondary cause in clinically suspected patient.
Location-Aided Uplink Transmission for User-Centric Cell-Free Massive MIMO Systems: A Fairness Priority Perspective
Authors: Wei Chen , Xu Kui , Shen Zhexian , Xia Xiaochen , Xie Wei , Li Chunguo
Published: January 2022

In this paper, we investigate the uplink transmission for user-centric cell-free massive multiple-input multiple-output (MIMO) systems. The largest-large-scale-fading-based access point (AP) selection method is adopted to achieve a user-centric operation. Under this user-centric framework, we propose a novel inter-cluster interference-based (IC-IB) pilot assignment scheme to alleviate pilot contamination. Considering the local characteristics of channel estimates and statistics, we propose a location-aided distributed uplink combining scheme based on a novel proposed metric representing inter-user interference to balance the relationship among the spectral efficiency (SE), user equipment (UE) fairness and complexity, in which the normalized local partial minimum mean-squared error (LP-MMSE) combining is adopted for some APs, while the normalized maximum ratio (MR) combining is adopted for the remaining APs. A new closed-form SE expression using the normalized MR combining is derived and a novel metric to indicate the UE fairness is also proposed. Moreover, the max-min fairness (MMF) power control algorithm is utilized to further ensure uniformly good service to the UEs. Simulation results demonstrate that the channel estimation accuracy of our proposed IC-IB pilot assignment scheme outperforms that of the conventional pilot assignment schemes. Furthermore, although the proposed location-aided uplink combining scheme is not always the best in terms of the per-UE SE, it can provide the more fairness among UEs and can achieve a good trade-off between the average SE and computational complexity.
Enhancement of Carrimycin Production Via Traditional Mutagenesis with Metabolic Engineering in Streptomyces Spiramyceticus 54IA
Authors: Li Kemeng , Dai Jianlu , Liu Juanjuan , Hao Tianyi , He Weiqing
Published: January 2022

Background: Carrimycin is a new approved class I antibiotic in China. The novel carrimycin producing strain, Streptomyces spiramyceticus 54IA, was constructed by CRISPR-Cas9 editing system without insertion of antibiotics resistant gene. The problem of low yield limits this strain in large scale fermentation. In this study, the carrimycin production was significantly improved by strain mutagenesis coupled metabolic engineering. Results: The sspD gene is responsible for degradation of triacylglycerol to provide precursors of the polyketide biosynthesis. The extra sspD gene controlled by the promoters of pks and bsm42 genes could moderately enhance carrimycin production. The Bsm42 was identified to play a pathway-specific positive regulator for carrimycin biosynthesis. Due to production of carrimycin significantly enhanced by bsm42 overexpression, the two different length promoters of bsm42 individually ligated with two reporter genes were used to monitor bsm42 expression for screening the higher carrimycin production mutants treated by plasma and ultraviolet. 47% of the 608 selected mutants had higher fermentation titer than the starting strain. The shorter promoter of bsm42 displayed more appropriate for selection of the carrimycin production improved mutants. The F2R-15 mutant had highest titer (1010±30 μg/mL), which was about 9 times higher than that of 54IA strain. Comparative analysis of transcriptome profiles of F2R-15 mutant and 54IA strains found 158 differential expression genes with more than 2 fold-changes. The up-regulated genes were associated with macrolide precursor biosynthesis, macrolide-inactivation, antibiotics transporter, oxidative phosphorylation; while the most down-regulated genes were referring to the primary metabolites synthetic genes and biosynthetic genes of other secondary metabolites. Conclusion: These results suggested that manipulation of the positive regulatory gene bsm42 and traditional mutagenesis coupled with reporter-guided mutant selection method facilitated selection of carrimycin high-yielding mutants.
Changes in the Prevalence of Hyperuricemia in Clients of Health Examination in Eastern China, 2009 to 2019
Authors: She Dunmin , Wang Yongliang , Liu Jing , Luo Na , Feng Shangyong , Li Ying , Xu Jin , Xie Shichun , Zhu Yan , Xue Ying , Zhang Zhenwen
Published: January 2022

Background: With the continuous improvement of people's living standards, the incidence of hyperuricemia (HUA) is increasing globally. The prevalence of HUA ranged in terms of region, race, and age. This study aims to investigate the changes in the prevalence of HUA in clients of health examination in Eastern China between 2009 and 2019. Methods: Chinese men and women aged 20-79 years (n = 4847 in the 2009 cohort and n = 12188 in 2019) who had received health examinations were enrolled. Serum uric acid (UA) levels and biochemical parameters, including fasting blood-glucose (FBG), triglyceride (TG), total cholesterol (CHOL), high-density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine (Cr) and blood urea nitrogen (BUN) were evaluated. The prevalence of HUA in different age groups were measured, and the correlation of biochemical parameters with the onset of HUA were analyzed. Results: The prevalence of HUA was 18.7% in the 2019 cohort, which was significantly higher than that in 2009 (13.3%). In females, the prevalence of HUA was significantly higher in 2019 than 2009 for age groups of 20-29 and 30-39 years. In male population, 2019 cohort had significantly higher age-specific prevalence for all age groups than 2009 cohort. Young men aged 20-29 years became the main population of HUA in the 2019 male cohort, whereas middle-aged men aged 40-49 years had the highest prevalence of HUA in the 2009 male cohort. The prevalence rates of HUA in all BMI groups in 2019 cohort were significantly higher than those in 2009 cohort. Spearmen’s correlation analysis and Logistic regression analysis indicated that BMI was positively correlated with the onset of HUA. The receiver-operating characteristic curve (ROC) analysis showed BMI＞24.48kg/m2 and BMI＞23.84 kg/m2 displayed good capacities to discriminate the population with HUA from those without HUA in 2009 and 2019 cohort, respectively. Conclusions: In recent 10 years, the prevalence of HUA was increased rapidly in Chinese adults, especially in males. Young men aged 20-29 years in the 2019 cohort replaced the middle-aged males (40-49 years old) in the 2009 cohort, and became the main population of male HUA in the 2019 cohort. BMI was positively correlated with HUA, and might be a potential risk factors to predict the onset of HUA.