bluuebunny/crossref_metadata_2025 huggingface dataset:
Cost-comparison analysis of diffusion weighted magnetic resonance imaging (DWMRI) versus second look surgery for the detection of residual and recurrent cholesteatoma
Authors: Choi David L. , Gupta Michael K. , Rebello Ryan , Archibald Jason D.
Published: November 2019

Background

Cholesteatoma is a destructive, erosive growth of keratinizing squamous epithelium in the middle ear cleft. Following treatment with a canal wall-up (CWU) tympanomastoidectomy, surveillance of residual and recurrent disease has traditionally been achieved through a second look tympanotomy following the initial procedure. Historically, MRI sequences have been inadequate at differentiating between granulation tissue, inflammation, and cholesteatoma. Recent literature has shown diffusion-weighted magnetic resonance imaging (DWMRI) to be a viable alternative to second look surgery for the detection of residual or recurrent disease. The goal of the present study was to perform a cost analysis of DWIMRI versus second look surgery in the detection of residual or recurrent cholesteatoma following combined approach tympanomastoidectomy.

Methods

A probabilistic decision tree model was generated from a literature review to compare traditional second look surgery with DWMRI. Cost inputs were obtained from the Ontario Case Costing Initiative, the Ontario Health Insurance Plan (OHIP) schedule of benefits. Costs were reported in Canadian dollars and a payer perspective was adopted. A probabilistic sensitivity analysis was performed.

Results

According to the probabilistic sensitivity analysis, mean cost difference of traditional second look tympanotomy versus echo planar imaging (EPI) DWMRI was $180.27CAD, 95%CI [$177.32, $188,32] in favour of second-look tympanotomy. However, mean cost difference of traditional second look tympanotomy versus non-EPI DWMRI was $390.66CAD, 95%CI [$381.52, $399.80] in favour of non-EPI DWMRI.

Conclusions

Diffusion-weighted MRI, specifically non-EPI sequences, are a viable cost-saving alternative to second-look tympanotomy in the setting of detecting residual or recurrent cholesteatoma.
Computed tomography-guided thoracoscopic debridement for multiple loculated organizing empyema: a case report
Authors: Aoki Masaya , Umehara Tadashi , Morizono Shoichiro , Tokuda Yasuhiro , Kamimura Go , Tokunaga Takuya , Suzuki Souichi , Takeda Aya Harada , Maeda Koki , Nagata Toshiyuki , Yokomakura Naoya , Kariatsumari Kota , Ueda Kazuhiro , Sato Masami
Published: November 2019

Background

Video-assisted thoracoscopic surgery (VATS) for organizing empyema is challenging because fibrous septa and peel within the cavity are thickened and hardened. Some patients have multiple isolated empyema cavities that require debridement individually because firm intrathoracic adhesion was developed during this phase. If the debridement was incomplete as a result of worrying about an accidental injury of the surrounding organ, additional interventions may be required due to the persistent empyema cavity or insufficient expansion of the ipsilateral lung. We here describe a representative case with multiple loculated organizing empyema that could safely and reliably perform VATS debridement under C-arm cone-beam computed tomography (CBCT).

Case presentation

A 67-year-old woman was admitted to our department for the treatment of right empyema. Chest computed tomography showed fluid collection in three independent spaces within the right thoracic cavity. It was assumed that a firm adhesion between the lung and chest wall was developed because about 7 weeks passed since the onset. Therefore, we decided to use CBCT to completely debride three empyema cavities separately by VATS. One cavity was only in a narrow range with the chest wall, and it was located on the back of cost rib cartilage. By clicking any intended anatomical structures on CBCT images, the position was readily depicted by lase projection on the body surface, which helped to place the best skin incision. Moreover, in other cavities, CBCT after initial debridement showed insufficiently dissected cavity. Additional debridement resulted in a successful shrinkage of the empyema cavity.

Conclusion

We believe that VATS debridement under CBCT guidance is one of the useful treatment options for multiple loculated organizing empyema.
Evaluation and comparison between the bactericidal effect of diode laser irradiation (970 nm) and silver nanoparticles on Enterococcus faecalis bacterial strain (an in vitro study)
Authors: Sadony Doaa M. , Montasser Karim
Published: November 2019

Background/Aims

Today, the using of diode lasers in dentistry has made a significant progress; it increased the speed of treatment, decreased the time of healing, and showed a bactericidal effect. The thermal effects should be considered in root canal treatment by laser, as the temperature rises to critical levels, causing tissues damage and any thermal change occurs after laser irradiation. The temperature can rise up to 10 °C above the body temperature for less than 2–3 min without damaging the periodontal tissue or burring the tooth structure by using cooling. Antibacterial properties of silver nanoparticles (Ag-NPs) were reducing Gram-positive and Gram-negative bacterial growth, due to a larger surface to volume ratio of nanoparticles. The goal of this study is to evaluate the bactericidal effect of diode laser irradiation (970 nm), the silver nanoparticles in root canals infected by Enterococcus faecalis bacteria, and the thermal change that occurs after laser application.

Materials and methods

Forty-five extracted single-rooted human maxillary anterior teeth were collected and used as a container for the test. The samples are inoculated by Enterococcus faecalis bacterial strain and randomly divided into three groups: group I (control) (n = 15), group II (Enterococcus faecalis bacteria and silver nanoparticles) (n = 15), and group III (Enterococcus faecalis bacteria and diode laser) (n = 15). The laser group was divided into subgroups according to the time of laser irradiation (20 s, 30 s, and 40 s).

Results

There was a significant difference between the treated groups, in which the laser group showed a high bactericidal effect than the other groups at the time of radiation 40 s, without damaging the tooth structure or periodontal ligament.

Conclusion

Diode laser with proper parameters is used as an adjunctive endodontic disinfection modality due to its antibacterial effect with a temperature tolerated by periodontal tissues with safety limit.
Modeling full-wavefield time-varying sea-surface effects on seismic data: A mimetic finite-difference approach
Authors: Konuk Tugrul , Shragge Jeffrey
Published: November 2019

Seismic-data processing flows often ignore spatial and temporal variations in the sea surface during marine seismic acquisition by assuming a flat free surface. However, weather patterns during data acquisition can generate rough sea conditions, which can significantly influence seismic full-wavefield source behavior, including ghost reflections and surface-related multiples, by introducing spatial and temporal distortions of the seismic wavelet. To investigate the effects of rough seas on seismic wave propagation, we have developed and solved a new acoustic wave equation using a mimetic finite-difference time-domain (MFDTD) scheme that uses a dynamic (i.e., moving) generalized coordinate system defined to be conformal to the assumed known time-varying free surface. This “sea-surface” coordinate system allows us to model the full dynamic effects associated with this complex boundary condition. Numerical examples demonstrate that the developed MFDTD method can accurately simulate seismic wavefield propagation on a moving mesh for significant wave heights of 5 m and beyond, and it is thus a reliable tool for applications involving modeling, processing, imaging, and inversion of seismic data acquired in rough seas.
Mental health and well-being of fathers of children with intellectual disabilities: systematic review and meta-analysis
Authors: Dunn Kirsty , Kinnear Deborah , Jahoda Andrew , McConnachie Alex
Published: November 2019

Background

Caring for a child with intellectual disabilities can be a very rewarding but demanding experience. Research in this area has primarily focused on mothers, with relatively little attention given to the mental health of fathers.

Aims

The purpose of this review was to summarise the evidence related to the mental health of fathers compared with mothers, and with fathers in the general population.

Method

A meta-analysis was undertaken of all studies published by 1 July 2018 in Medline, PsycINFO, CINAHL and EMBASE, using terms on intellectual disabilities, mental health and father carers. Papers were selected based on pre-defined inclusion and exclusion criteria.

Results

Of 5544 results, 20 studies met the inclusion criteria and 12 had appropriate data for meta-analysis. For comparisons of fathers with mothers, mothers were significantly more likely to have poor general mental health and well-being (standardised mean difference (SMD) −0.38, 95% CI −0.56 to −0.20), as well as higher levels of depression (SMD, −0.46; 95% CI −0.68 to −0.24), stress (SMD, −0.32; 95% CI −0.46 to −0.19) and anxiety (SMD, −0.30; 95% CI −0.50 to −0.10).

Conclusions

There is a significant difference between the mental health of father and mother carers, with fathers less likely to exhibit poor mental health. However, this is based on a small number of studies. More data is needed to determine whether the general mental health and anxiety of father carers of a child with intellectual disabilities differs from fathers in the general population.
Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits
Authors: Aksit Melis A , Pace Rhonda G , Vecchio-Pagán Briana , Ling Hua , Rommens Johanna M , Boelle Pierre-Yves , Guillot Loic , Raraigh Karen S , Pugh Elizabeth , Zhang Peng , Strug Lisa J , Drumm Mitch L , Knowles Michael R , Cutting Garry R , Corvol Harriet , Blackman Scott M
Published: November 2019

Context

Individuals with cystic fibrosis (CF) develop a distinct form of diabetes characterized by β-cell dysfunction and islet amyloid accumulation similar to type 2 diabetes (T2D), but generally have normal insulin sensitivity. CF-related diabetes (CFRD) risk is determined by both CFTR, the gene responsible for CF, and other genetic variants.

Objective

To identify genetic modifiers of CFRD and determine the genetic overlap with other types of diabetes.

Design and Patients

A genome-wide association study was conducted for CFRD onset on 5740 individuals with CF. Weighted polygenic risk scores (PRSs) for type 1 diabetes (T1D), T2D, and diabetes endophenotypes were tested for association with CFRD.

Results

Genome-wide significance was obtained for variants at a novel locus (PTMA) and 2 known CFRD genetic modifiers (TCF7L2 and SLC26A9). PTMA and SLC26A9 variants were CF-specific; TCF7L2 variants also associated with T2D. CFRD was strongly associated with PRSs for T2D, insulin secretion, postchallenge glucose concentration, and fasting plasma glucose, and less strongly with T1D PRSs. CFRD was inconsistently associated with PRSs for insulin sensitivity and was not associated with a PRS for islet autoimmunity. A CFRD PRS comprising variants selected from these PRSs (with a false discovery rate < 0.1) and the genome-wide significant variants was associated with CFRD in a replication population.

Conclusions

CFRD and T2D have more etiologic and mechanistic overlap than previously known, aligning along pathways involving β-cell function rather than insulin sensitivity. Two CFRD risk loci are unrelated to T2D and may affect multiple aspects of CF. An 18-variant PRS stratifies risk of CFRD in an independent population.
A unique transgenic mouse model exhibiting a myeloproliferative disease-like phenotype
Authors: Kito Yusuke , Hanamatsu Yuki , Kawashima Keisuke , Saigo Chiemi , Takeuchi Tamotsu
Published: November 2019

Transmembrane protein 207 (TMEM207) is an important molecule involved in invasiveness of gastric signet ring cell carcinoma. To understand the pathobiological effects of TMEM207, we generated thirteen transgenic mouse lines, designated C57BL/6-Tg (ITF-TMEM207), where mouse TMEM207 is expressed heterotrophically, regulated by the proximal promoter of the murine intestinal trefoil factor (ITF) gene (also known as Tff3). A C57BL/6-Tg (ITF-TMEM207) mouse line unexpectedly exhibited a high incidence of a spontaneous condition resembling myeloproliferative disease-like phenotype. Increased numbers of CD117+ cells and appearance of dysplastic myeloid cells in bone marrow were observed. These histopathological features suggested human myeloproliferative disease or its precursor manifestations, and were found in almost all mice within one year. TMEM207 immunoreactivity was identified in megakaryocytes and erythroblasts of the transgenic mice. The ITF-TMEM207 construct was inserted into Atg4b on murine chromosome 1. Myeloproliferative disease was not observed in other C57BL/6-Tg (ITF-TMEM207) transgenic mouse lines. However, although several other genetically manipulated animal models of myeloproliferative disease and Atg4b knockout mice exist, this mouse line harboring a mutated Atg4b gene, and with overexpression of TMEM207 protein, has not been reported as a model of myeloproliferative disease to date. The present study demonstrated that the C57BL/6-Tg (ITF-TMEM207) mouse may be a valuable model for improved understanding of human myeloproliferative disease.
FGF signaling in mammary gland fibroblasts regulates multiple fibroblast functions and mammary epithelial morphogenesis
Authors: Sumbal Jakub , Koledova Zuzana
Published: November 2019

Fibroblast growth factor (FGF) signaling is crucial for mammary gland development. Although multiple roles for FGF signaling in the epithelium have been described, the function of FGF signaling in mammary stroma has not been elucidated. In this study, we investigated FGF signaling in mammary fibroblasts. We found that murine mammary fibroblasts express FGF receptors FGFR1 and FGFR2 and respond to FGF ligands. In particular, FGF2 and FGF9 induce sustained ERK1/2 signaling and promote fibroblast proliferation and migration in 2D cultures. Intriguingly, only FGF2 induces fibroblast migration in 3D extracellular matrix (ECM) through regulation of actomyosin cytoskeleton and promotes force-mediated collagen remodeling by mammary fibroblasts. Moreover, FGF2 regulates production of ECM proteins by mammary fibroblasts, including collagens, fibronectin, osteopontin and matrix metalloproteinases. Finally, using organotypic 3D co-cultures we show that FGF2 and FGF9 signaling in mammary fibroblasts enhances fibroblast-induced branching of mammary epithelium by modulating paracrine signaling, and that knockdown of Fgfr1 and Fgfr2 in mammary fibroblasts reduces branching of mammary epithelium. Our results demonstrate a pleiotropic role for FGF signaling in mammary fibroblasts, with implications for regulation of mammary stromal functions and epithelial branching morphogenesis.
Ethics of War and Ethics in War
Authors: Babic Jovan
Published: November 2019

The paper examines the justification of warfare. The main thesis is that war is very difficult to justify, and justification by invoking “justice” is not the way to succeed it. Justification and justness (“justice”) are very different venues: while the first attempts to explain the nature of war and offer possible schemes of resolution (through adequate definitions), the second aims to endorse a specific type of warfare as correct and hence allowed – which is the crucial part of “just war theory.” However, “just war theory,” somewhat Manichean in its nature, has very deep flaws. Its final result is criminalization of war, which reduces warfare to police action, and finally implies a very strange proviso that one side has a right to win. All that endangers the distinction between ius ad bellum and ius in bello, and destroys the collective character of warfare (reducing it to an incomprehensible individual level, as if a group of people entered a battle in hopes of finding another group of people willing to respond). Justification of war is actually quite different – it starts from the definition of war as a kind of conflict which cannot be solved peacefully, but for which there is mutual understanding that it cannot remain unresolved. The aim of war is not justice, but peace, i.e. either a new articulation of peace, or a restoration of the status quo ante. Additionally, unlike police actions, the result of war cannot be known or assumed in advance, giving war its main feature: the lack of control over the future. Control over the future, predictability (obtained through laws), is a feature of peace. This might imply that war is a consequence of failed peace, or inability to maintain peace. The explanation of this inability (which could simply be incompetence, or because peace, as a specific articulation of distribution of social power, is not tenable anymore) forms the justification of war. Justice is always an important part of it, but justification cannot be reduced to it. The logic contained here refers to ius ad bellum, while ius in bello is relative to various parameters of sensitivity prevalent in a particular time (and expressed in customary and legal rules of warfare), with the purpose to make warfare more humane and less expensive.
The use of electron microscopy in the diagnosis of focal segmental glomerulosclerosis: are current pathological techniques missing important abnormalities in the glomerular basement membrane?
Authors: Davis Justin , Tjipto Alwie , Hegerty Katharine , Mallett Andrew
Published: November 2019

Background:There is an increasing appreciation that variants of theCOL4Agenes may be associated with the development of focal segmental glomerulosclerosis (FSGS). On electron microscopy, such variants may produce characteristic changes within the glomerular basement membrane (GBM). These changes may be missed if glomerular lesions histologically diagnosed as FSGS on light microscopy are not subjected to electron microscopy.

Methods:We conducted a retrospective cohort analysis of all patients presenting to two hospitals who received a primary histological diagnosis of FSGS to see if these samples underwent subsequent electron microscopy. Each such sample was also scrutinised for the presence of characteristic changes of an underlying type IV collagen disorder

Results:A total of 43 patients were identified. Of these, only 30 underwent electron microscopy. In two samples there were histological changes detected that might have suggested the underlying presence of a type IV collagen disorder. Around one in three biopsy samples that had a histological diagnosis of FSGS were not subjected to electron microscopy.

Conclusion:Renal biopsy samples that have a histological diagnosis of primary FSGS not subjected to subsequent electron microscopy may potentially miss ultrastructural changes in the GBM that could signify an underlying type IV collagen disorder as the patient’s underlying disease process. This could potentially affect both them and their families’ investigative and management decisions given potential for implications for transplant, heritability and different disease pathogenesis. This represents a gap in care which should be reflected upon and rectified via iterative standard care and unit-level quality assurance initiatives.
Peptide arrays of three collections of human sera from patients infected with mosquito-borne viruses
Authors: Martinez Viedma Maria del Pilar , Kose Nurgun , Parham Leda , Balmaseda Angel , Kuan Guillermina , Lorenzana Ivette , Harris Eva , Crowe Jr. James E. , Pickett Brett E.
Published: November 2019

Background: Global outbreaks caused by emerging or re-emerging arthropod-borne viruses (arboviruses) are becoming increasingly more common. These pathogens include the mosquito-borne viruses belonging to the Flavivirus and Alphavirus genera. These viruses often cause non-specific or asymptomatic infection, which can confound viral prevalence studies. In addition, many acute phase diagnostic tests rely on the detection of viral components such as RNA or antigen. Standard serological tests are often not reliable for diagnosis after seroconversion and convalescence due to cross-reactivity among flaviviruses.

Methods: In order to contribute to development efforts for mosquito-borne serodiagnostics, we incubated 137 human sera on individual custom peptide arrays that consisted of over 866 unique peptides in quadruplicate. Our bioinformatics workflow to analyze these data incorporated machine learning, statistics, and B-cell epitope prediction.

Results: Here we report the results of our peptide array data analysis, which revealed sets of peptides that have diagnostic potential for detecting past exposure to a subset of the tested human pathogens including Zika virus. These peptides were then confirmed using the well-established ELISA method.

Conclusions: These array data, and the resulting peptides can be useful in diverse efforts including the development of new pan-flavivirus antibodies, more accurate epitope mapping, and vaccine development against these viral pathogens.
Front Matter: Volume 7 (Proceedings of CBU)
Authors: Hájek Petr , Vít Ondřej
Published: November 2019

This PDF file contains the front matter associated with CBU Proceedings Volume 7 including the Title Page, Copyright information, Table of Contents, Introduction, and Conference Committee listing.
Apresentação
Authors: Figueira de Souza Corrêa Elisa
Published: November 2019

Apresentação dos artigos da Revista Principia XXXVIII.
Caracterização simbólica através de símiles animais na Ilíada
Authors: Classe Colonnelli Marco Valério
Published: November 2019

O intuito deste artigo é demonstrar, a partir de alguns símiles, como Homero produz uma caracterização concisa de seus heróis. A perspectiva de abordagem neste estudo é comprovar a eficácia do uso dos símiles pelo poeta em consonância com a obra de Aristóteles, Investigação dos Animais, que nos permite aferir certo valor simbólico de determinados animais ainda no séc. IV a.C. Partindo de comparações com animais, o poeta produz símiles que formam um quadro imediato e eficaz do herói, projetado pela força simbólica e analógica que o animal evoca como termo comparativo na cultura grega arcaica e clássica.
Os profissionais do sobrenatural: mágos, góes e pharmakeús
Authors: V. do Nascimento Braga Dulcileide
Published: November 2019

O presente artigo objetiva, ao pressupor que as ações mágicas constituem práticas passíveis de aprendizado, apresentar a análise da estrutura vocabular dos termos que classificam os profissionais da magia. Busca-se, também, a partir da tradição mítico-literária grega, demonstrar que tais profissionais têm uma prática registrada em diversos períodos da literatura grega e influenciaram ações que extrapolam o viés temporal.
A rare case of a diverticular perforation associated with colo-urachal fistula presenting as anaphylaxis
Authors: Yang D , Pearson D , Smith D
Published: November 2019

Diverticular disease is a common clinical condition among Western populations, which increases with age. It can present in a variety of manners and has myriad of potential disease complications. We present a rare case of an adult patient with an extraperitoneal complications of a diverticular perforation presenting with facial swelling due to a colo-urachal fistula associated with a patent urachal remnant. Perforation should be considered in patients presenting with surgical emphysema with background of diverticular disease.
The role of public research agencies in building agri-food bioscience impact and innovation capacity in sub-Saharan Africa: The challenge beyond science capability
Authors: Altshul Helen J. , McMillan Larelle , Hall Andrew
Published: November 2019

Bioscience advances present important opportunities for economic development and sustainable intensification of African agriculture. In the global North, the private sector invests heavily in applied research, whereas in Africa the public sector shoulders the burden of developing research capacity. This article explores whether public science agencies should assume an expanded role to approach bioscience capacity using a system lens – developing capability for innovation within the whole system. The article identifies the types of intervention, beyond skills development, research infrastructure and funding that could enhance the potential of bioscience as an innovation driver. Following a summary of trends, a model of the system capacities required for bioscience impact and innovation is proposed and used to analyse a case study from East Africa. The results suggest that a fundamental rethink of the role of public science agencies within the wider biosciences landscape is required, necessitating complementary investments and a more complex network of partnerships across public and private sectors.
John Dewey'in Naturalistik Din Anlayışı
Authors: Tanış Abdulkadir , ÇITIR İlhami
Published: November 2019

Pragmatizmin
önde gelen isimlerinden biri olan John Dewey, Ortak Bir İman adlı
eserinde din hakkındaki görüşlerini detaylıca ifade etmiştir. Temel olarak
natüralistik bir bakış açısından hareketle dini ele alan Dewey, konu hakkındaki
görüşlerini din ve dinsel arasında öngördüğü ayrıma dayandırmaktadır. Burada
din, bir dinin belirli inanç veya pratikler kümesini ya da bu inanç ve
pratikler etrafında şekillenmiş olan kurumsal yapıyı dile getirmektedir. Buna
karşın, dinsel, yaşamdaki bütün insani ideal amaçlara yönelik benimsenebilecek
bir tutumu ifade etmektedir. Onun ileri sürdüğü görüşün özü, dinî olanı daha
ziyade doğaüstüyle özdeş gören tarihsel din, kurum veya öğretilerin reddedilmesi,
bu sayede tecrübedeki dinsel öğelerin, tarihsel dinlerin getirdiği inanç, dogma
vb. öğelerin yükünden özgürlüğe kavuşturulmasıdır. Dolayısıyla, o, doğaüstüne
başvurulmadan dinî tecrübenin doğal dünyanın olumsal koşulları içerisinde
yorumlanması gerektiğini savunmaktadır. Bu çalışmada, Dewey’in din konusundaki
iddiaları eleştirel bir bakışla analiz edilecektir. Bunun için öncelikle onun
din konusundaki görüşleri betimsel olarak detaylı bir şekilde ortaya konulacak
ve daha sonra bunların değeri tartışılacaktır. İlk olarak, din ve Tanrı
konusundaki görüşleri geleneksel teist ve realist anlayışlarla
karşılaştırıldığında Dewey’in bir teist veya realist olarak
değerlendirilemeyeceği ifade edilecektir. İkinci olarak, görüşleri her ne kadar
geleneksel realist veya teist anlayışlar bağlamında yorumlanmaya müsait olmasa
da, onun tam anlamıyla anti-realist veya ateist bir bakış açısına sahip
olmadığı daha ziyade orta yolcu bir noktada durduğu iddia edilecektir
Imaginarios, obras y autores en la literatura latinoamericana: Voces judaicas en la literatura brasileña
Authors: Brum Pedro
Published: November 2019

En América Latina, conocemos bien el enunciado de pertenencia, el lugar intersticial de la voz del inmigrante. Punto de habla —y de narrativa— que conlleva dificultades al momento de superar el complejo proceso de mestizaje étnico y cultural. Al indagar sobre estos aspectos, el presente artículo produce reflexiones sobre la presencia judía en la literatura brasileña.
Representaciones culturales, narraciones y estéticas: La emergencia de las divas en el campo cultural latinoamericano: representaciones artísticas en la crónica modernista
Authors: Viu Adagio Julieta
Published: November 2019

Las crónicas que Rubén Darío publica en la prensa chilena y Manuel Gutiérrez Nájera en la mexicana consolidan, a fines del siglo XIX, a la diva como tópicoliterario. Estas producciones forjan un imaginario que celebra la belleza, la armonía y la exclusividad y que por ello resulta contestatario de la concepción burguesa del arte y de la vida que rige las sociedades latinoamericanas finiseculares. En este artículo, consideramos las representaciones que los modernistas mencionados realizan de Sarah Bernhardt y Adelina Patti para analizar la emergencia del divismo, esto es, una narración donde la hegemonía de la estrella logra desplazar a un segundo plano a la obra interpretada. Contrastaremos este corpus con la crítica teatral que Paul Groussac escribe sobreSarah Bernhardt focalizada en la actriz y sus habilidades para la interpretación.
Producción audiovisual, políticas culturales y de la memoria: Documentales, justicia y memorias. Repre- sentación de los juicios a responsables de las dictaduras de los ’70 en Argentina y Chile
Authors: Nicola Mariné
Published: November 2019

En este trabajo nos proponemos analizar las producciones audiovisuales documentales sobre los juicios en torno a los delitos cometidos durante las dictaduras cívico–militares de la década de los ’70 en el caso argentino y chileno. Al mismo tiempo, considerar a estos filmes en el proceso deconstrucción de memorias y su relación con las políticas de la memoria delineadas y desarrolladas en ambos países en torno a la producción audiovisual.Nos planteamos trabajar de manera comparativa las producciones documentales que representen los procesos judiciales en el caso argentino y el caso chileno, poniendo en tensión, por un lado, la relación historia–cine, hechos comprobables–representación de la realidad y, por otro, producción audiovisual y construcción de memorias. Cabe aclarar que el foco de indagación se condensa en la representación de los juicios y las memorias que entran en disputa, pujan, luchan en las tramas narrativas de los audiovisuales que toman este tema como central para sus producciones. Se estudia comparativamente de forma sincrónica dos casos con ciertas similitudes en la implantación e implementación de las dictaduras cívico–militares,pero con notables diferencias en los procesos de transición democrática, juzgamiento a los responsables y delineamientos de políticas de memoria, abordando el análisis comparativo en cuanto a lo que sucede con el juzgamiento y la representación fílmica de estos procesos en ambos países.Los objetivos que guían esta investigación se proponen considerar los documentales según país de procedencia, marcando diferencias en la modalidad derepresentación: qué elementos y recursos utilizan, cómo representan los acontecimientos y qué memorias entran en disputa en sus narrativas; indagar sobre las estrategias, recursos y dispositivos utilizados para la representación de los juicios.
Clinical Considerations in Working with Clients in the Coming Out Process
Authors: Chazin Daniel , Klugman Sam
Published: November 2019

Mandel (2014) describes the conceptualization, assessment, and treatment of "Adam," a hybrid client presenting with depression, cannabis abuse, perfectionism, and distress related to his sexual orientation, which appeared to be fueling these psychological problems. In this commentary, we examine theoretical and clinical issues raised by this case regarding clients’ experiences with coming out. Drawing on the case and pertinent research, we highlight clinical challenges involved in helping clients navigate issues of identity development and intersection, interpersonal disclosure, internalized homophobia, and community connectedness. We present specific strategies for tailoring interventions to the diverse experiences and needs of sexual minority clients. Throughout the commentary, we reflect on potential intrapersonal, interpersonal, and systemic processes that may impact clients’ identity integration and psychological well-being.
Eigenvalues for a class of singular problems involving p(x)-Biharmonic operator and q(x)-Hardy potential
Authors: Khalil Abdelouahed El , Laghzal Mohamed , Alaoui My Driss Morchid , Touzani Abdelfattah
Published: November 2019

In this paper, we consider the nonlinear eigenvalue problem:

$$\begin{array}{}
\displaystyle
\begin{cases}
{\it\Delta}(|{\it\Delta} u|^{p(x)-2}{\it\Delta} u)= \lambda \frac{|u|^{q(x)-2}u}{{\delta(x)}^{2q(x)}} \;\; \mbox{in}\;\; {\it\Omega}, \\
u\in W_0^{2,p(x)}({\it\Omega}),
\end{cases}
\end{array}$$

where Ω is a regular bounded domain of ℝN, δ(x) = dist(x, ∂Ω) the distance function from the boundary ∂Ω, λ is a positive real number, and functions p(⋅), q(⋅) are supposed to be continuous on Ω satisfying

$$\begin{array}{}
\displaystyle
1 \lt \min_{\overline{{\it\Omega} }}\,q\leq \max_{\overline{{\it\Omega}}}\,q \lt \min_{\overline{{\it\Omega} }}\,p \leq \max_{\overline{{\it\Omega}}}\,p \lt \frac{N}{2} \mbox{ and } \max_{\overline{{\it\Omega}}}\,q \lt p_2^*:= \frac{Np(x)}{N-2p(x)}
\end{array}$$

for any x ∈ Ω. We prove the existence of at least one non-decreasing sequence of positive eigenvalues. Moreover, we prove that sup Λ = +∞, where Λ is the spectrum of the problem. Furthermore, we give a proof of positivity of inf Λ > 0 provided that Hardy-Rellich inequality holds.
Gapless Lines and Gapless Proofs: Intersections and Continuity in Euclid’s Elements
Authors: De Risi Vincenzo
Published: November 2019

In this paper, I attempt a reconstruction of the theory of intersections in the geometry of Euclid. It has been well known, at least since the time of Pasch onward, that in the Elements there are no explicit principles governing the existence of the points of intersections between lines, so that in several propositions of Euclid the simple crossing of two lines (two circles, for instance) is regarded as the actual meeting of such lines, it being simply assumed that the point of their intersection exists. Such assumptions are labelled, today, as implicit claims about the continuity of the lines, or about the continuity of the underlying space. Euclid’s proofs, therefore, would seem to have some demonstrative gaps that need to be filled by a set of continuity axioms (as we do, in fact, find in modern axiomatizations).

I show that Euclid’s theory of intersections was not in fact based on any notion of continuity at all. This is not only because Greek concepts of continuity (such as the Aristotelian ones) were largely insufficient to ground a geometrical theory of intersections, but also, at a deeper level, because continuity was simply not regarded as a notion that had any role to play in the latter theory. Had Euclid been asked to explain why the points of intersections of lines and circles should exist, it would have never occurred to him to mention continuity in this connection. Ancient geometry was very different from ours, and it is only our modern views on continuity that tend to give rise to the expectation that this latter must be included in the foundations of elementary mathematics.

We may hope to reconstruct Euclid’s views on intersections if we undertake a critical examination both of the extension and of the limits of ancient diagrammatic practices. This is tantamount to attempting to understand to what extent the existence of an intersection point may be inferred just from the inspection of a diagram, and in which cases we need rather to supplement such inference by propositional rules. This leads us to discuss Euclid’s definition of a point, and to work out the details of the complex interaction between diagrams and text in ancient geometry. We will see, then, that Euclid may have possessed a theory of intersections that was sufficiently rigorous to dispel the main objections that could be advanced in antiquity.
Die Inszenierung von Text- und Werkgenesen in Dichter-, Künstler- und Komponistenhäusern
Authors: Plachta Bodo
Published: November 2019

The homes of poets, artists and composers are not only memorials and biographical museums but also places in which texts, pieces of art and music were created. A person’s biography is quickly revealed in these homes by looking at the original furniture and the typical objects of daily life common at the time. To make the creative work visible though, guidance and explanations are necessary. In many homes the pieces of work aren’t merely shown, instead, an attempt has been made to provide specific insight into the process of the creation of them. Not only are the relevant documents shown but also, using various media, the origins of the pieces are made comprehensible to the beholder. The origins are staged. Sometimes, with the help of drawers which can be opened, the stages of the origins can be contemplated (Franz Schubert, Wolfgang Koeppen) and then the manuscripts are illustrated in the order of their creation on a time beam (Honoré de Balzac). In Heinrich-Schütz’s home the development of a melody can be followed acoustically. But there are also homes in which their owners – mainly visual artists – even developed concepts for the keeping and archiving of the creation of their works (Gustave Moreau, Auguste Rodin) during their lifetimes, so that the observer can later experience them in all their authenticity in their original surroundings. In this article various forms of conveying the creation of works are presented, commented on and placed in the exploration context of places of creativity.
Vom Nutzen der Hybridedition
Authors: Kocher Ursula
Published: November 2019

The paper deals with the question, in which cases hybrid editions are indeed useful and not merely a duplication of the same content. Based on brief terminological considerations it examines which arguments are generally presented for this type of edition. In addition, the exemplarily selected hybrid editions show which concepts have led to this kind of presentation. Finally, the resulting requirements for hybrid editions are collated with the approach of the hybrid edition of Kurt Schwitters. Alle Texte (http://schwitters-digital.de).
The Effects of Micronutrient and Organic Fertilizers on Yield and Growth Characteristics of Sunflower (Helianthus annuus L.)
Authors: Nouraein Mojtaba , Bakhtiarzadeh Raheleh , Janmohammadi Mohsen , Mohammadzadeh Maryam , Sabaghnia Naser
Published: November 2019

To evaluate the effect of different micronutrients (Mn, Fe, Zn) and farmyard manure (FYM) on the vegetative, phenological, and achene yield components of sunflower a field experiment was conducted in Maragheh, North West of Iran during the growing season 2018–2019. The treatments were arranged in a split-plot design- with three replicates. The main plots assigned to two levels of FYM (0 and 20 t ha−1) and sub plots assigned to the recommended dose of three micronutrients (Mn, Fe, Zn). The results revealed significant improvements in the growth and yield of sunflower due to the main and interaction effects of farmyard manure and inorganic fertilizer application. The highest number of leaves and the highest leaf area was observed in a plant grown by FYM + Zn. However, there was no significant difference between micronutrients under inorganic condition (without FYM application). The highest leaf relative water content (RWC), plant height, internode distance, and chlorophyll was recorded for plants grown by Fe or Zn under FYM applied condition. Application of FYM and micronutrients reduced the number of days to flowering. However, the application of FYM significantly delayed plant maturity. Achene number per head, 100-achene weight, achene length, achene width, achene oil percent, achene yield, and harvest index significantly increased with the application of FYM and the best performance was in a plant grown by FYM + Zn and FYM + Fe. The percentage of hollow and empty achene was significantly reduced by the application of FYM. Combined applications of FYM and micronutrients has become an increasingly common practice.
The Political Role of Business Magnates in Competitive Authoritarian Regimes
Authors: Pleines Heiko
Published: November 2019

This contribution examines the role of business magnates (“oligarchs”) in political transitions away from competitive authoritarianism and towards either full authoritarianism or democracy. Based on 65 cases of competitive authoritarian regimes named in the academic literature, 24 historical cases with politically active business magnates are identified for further investigation. The analysis shows that in about half of those cases business magnates do not have a distinct impact on political regime change, as they are tightly integrated into the ruling elites. If they do have an impact, they hamper democratization at an early stage, making a transition to full democracy a rare exception. At the same time, a backlash led by the ruling elites against manipulation through business magnates makes a transition to full autocracy more likely than in competitive authoritarian regimes without influential business magnates.
Constructing fluid relationships through language: A study of address terms in a Japanese drama and its pedagogical implications
Authors: Yonezawa Yoko
Published: November 2019

This study investigates address practices among family members in a Japanese TV drama. It qualitatively analyses not only a speaker’s culturally normative use of address terms but also his/her deviations from the norm, including the use of terms that are atypical in Japanese communication. The study sheds light on dynamic aspects of interaction in Japanese in which the speaker creates meaning and constructs fluid relationships with other interlocutors through the use of address terms. The pedagogical implications of these findings are discussed, along with the value of using telecinematic discourse in teaching, to give learners of Japanese a socio-pragmatic understanding of address practices.
Suitability of FBG for Gain Flatness of 64 × 10 Gbps DWDM System Using Hybrid (EDFA+YDFA) Optical Amplifier in C + L Band up to 50 GHz (0.4 nm) Channel Spacing
Authors: Singh Harjit , Sheetal Anu
Published: November 2019

Gain flatness of erbium-doped fiber amplifier (EDFA) is an important aspect to support high speed multimedia applications for smart devices, cloud computing, big data analysis and high definition television (HDTV) as it achieves equal power for all dense wavelength division multiplexing (DWDM) channels. In this paper, we compare 32 and 64 channels 10 Gbps DWDM system using hybrid EDFA+ Ytterbium-doped silica fiber amplifier (YDFA) in C + L band for 0.4, 0.8 and 1.6 nm wavelength spacing along with FBG for gain flattening. The system performance has been analyzed in terms of optical signal to noise ratio and spectral gain fluctuation observed from the optical power spectrums. It is observed that YDFA although extends the amplification window of EDFA from 1530 to 1610 nm (C to L band), but gain fluctuates over the operating wavelength range. Gain flatness is enormously improved (5–10 dB) by adding FBG as a gain flattening filter to the hybrid (EDFA+YDFA) amplifier. It is found that as the channel spacing decreases (from 1.6 to 0.4 nm) and the number of channels increases (from 32 to 64), the gain reduces due to inter-channel crosstalk and four wave-mixing effect.
Shape-Based Analysis on Component-Graphs for Multivalued Image Processing
Authors: Grossiord Éloïse , Naegel Benoît , Talbot Hugues , Najman Laurent , Passat Nicolas
Published: November 2019

Connected operators based on hierarchical image models have been increasingly considered for the design of efficient image segmentation and filtering tools in various application fields. Among hierarchical image models, component-trees represent the structure of grey-level images by considering their nested binary level-sets obtained from successive thresholds. Recently, a new notion of component-graph was introduced to extend the component-tree to any grey-level or multivalued images. The notion of shaping was also introduced as a way to improve the anti-extensive filtering by considering a two-layer component-tree for grey-level image processing. In this article, we study how component-graphs (that extend the component-tree from a spectral point of view) and shapings (that extend the component-tree from a conceptual point of view) can be associated for the effective processing of multivalued images. We provide structural and algorithmic developments. Although the contributions of this article are theoretical and methodological, we also provide two illustration examples that qualitatively emphasize the potential use and usefulness of the proposed paradigms for image analysis purposes.
Prognostic significance of CD276 in non-small cell lung cancer
Authors: Zhang Changgong , Hao Xuezhi
Published: November 2019

Background

The expression and significance of CD276 in non-small cell lung cancer (NSCLC) was explored.

Method

The BioGPS database was used to analyze the expression level of CD276 in normal tissues. Studies on the expression of CD276 in NSCLC patients using the Oncomine database. The prognostic roles of CD276 in NSCLC was studied using the Kaplan-Meier plotter database.

Result

The BioGPS database showed CD276 expression in all the human normal tissues. Compared with normal lung tissue, CD276 gene highly expressed in NSCLC tissue at mRNA level (P<0.05). The expression level of CD276 gene was negatively correlated with overall survival (OS) of NSCLC patients. Subgroup analysis showed that CD276 expression level had a significant effect on OS of patients with lung adenocarcinoma, while in squamous cell carcinoma its expression level had no significant effect on OS.

Conclusion

According to the information mined from the tumor gene database, CD276 mRNA was found highly expressed in NSCLC tissue and the expression of CD276 has a significant impact on survival of NSCLC patients, which provides an important theoretical basis for further study of the role of CD276 in the occurrence and development of NSCLC.
Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIO
Authors: Yu Xiang-Rong , Cao Bo-Ling , Li Wei , Tian Ye , Du Zhong-Li
Published: November 2019

Detailed characterization of the permeability and vascular volume of brain tumor vasculature can provide essential insights into tumor physiology. In this study, we evaluated the consistency of measurements in tumor blood volume and examined the feasibility of using ultrasmall superparamagnetic iron oxide (USPIO) versus gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) as contrast agents for MR perfusion imaging of brain gliomas in C6 Rats. Eighteen rats were intracerebrally implanted with C6 glioma cells, randomly divided into two groups and examined by 3.0T perfusion MR imaging with Gd-DTPA and USPIO. Tumor relative cerebral blood volume (rCBV) and relative maximum signal reduction ratio (rSRRmax) were created based on analysis of MR perfusion images. The mean values for rCBV were 2.09 and 1.57 in the USPIO and the Gd-DTPA groups, respectively, and rSRRmax values were 1.92 and 1.02 in the USPIO and the Gd-DTPA groups, respectively, showing signifi cant differences in both rCBV and rSRRmax between the USPIO and the Gd-DTPA groups (P < 0.05). The results showed that early vascular leakage occurred with gadolinium rather than USPIO in perfusion assessment, revealing that USPIO was useful in perfusion MR imaging for the assessment of tumor vasculature.