bluuebunny/crossref_metadata_2025 huggingface dataset:
On the fractional Korn inequality in bounded domains: Counterexamples to the case ps < 1
Authors: Harutyunyan Davit , Mikayelyan Hayk
Published: February 2023

The validity of Korn’s first inequality in the fractional setting in bounded domains has been open. We resolve this problem by proving that in fact Korn’s first inequality holds in the case

p
s
>
1

ps\gt 1

for fractional

W

0

s
,
p

(

Ω

)

{W}_{0}^{s,p}\left(\Omega )

Sobolev fields in open and bounded

C

1

{C}^{1}

-regular domains

Ω
⊂

R

n

\Omega \subset {{\mathbb{R}}}^{n}

. Also, in the case

p
s
<
1

ps\lt 1

, for any open bounded

C

1

{C}^{1}

domain

Ω
⊂

R

n

\Omega \subset {{\mathbb{R}}}^{n}

, we construct counterexamples to the inequality, i.e., Korn’s first inequality fails to hold in bounded domains. The proof of the inequality in the case

p
s
>
1

ps\gt 1

follows a standard compactness approach adopted in the classical case, combined with a Hardy inequality, and a recently proven Korn second inequality by Mengesha and Scott [A Fractional Korn-type inequality for smooth domains and a regularity estimate for nonlinear nonlocal systems of equations, Commun. Math. Sci. 20 (2022), no. 2, 405–423]. The counterexamples constructed in the case

p
s
<
1

ps\lt 1

are interpolations of a constant affine rigid motion inside the domain away from the boundary and of the zero field close to the boundary.
EEG-based driver states discrimination by noise fraction analysis and novel clustering algorithm
Authors: Fu Rongrong , Li Zheyu , Wang Shiwei , Xu Dong , Huang Xiaodong , Liang Haifeng
Published: February 2023

Driver states are reported as one of the principal factors in driving safety. Distinguishing the driving driver state based on the artifact-free electroencephalogram (EEG) signal is an effective means, but redundant information and noise will inevitably reduce the signal-to-noise ratio of the EEG signal. This study proposes a method to automatically remove electrooculography (EOG) artifacts by noise fraction analysis. Specifically, multi-channel EEG recordings are collected after the driver experiences a long time driving and after a certain period of rest respectively. Noise fraction analysis is then applied to remove EOG artifacts by separating the multichannel EEG into components by optimizing the signal-to-noise quotient. The representation of data characteristics of the EEG after denoising is found in the Fisher ratio space. Additionally, a novel clustering algorithm is designed to identify denoising EEG by combining cluster ensemble and probability mixture model (CEPM). The EEG mapping plot is used to illustrate the effectiveness and efficiency of noise fraction analysis on the denoising of EEG signals. Adjusted rand index (ARI) and accuracy (ACC) are used to demonstrate clustering performance and precision. The results showed that the noise artifacts in the EEG were removed and the clustering accuracy of all participants was above 90%, resulting in a high driver fatigue recognition rate.
Scrollar invariants, syzygies and representations of the symmetric group
Authors: Castryck Wouter , Vermeulen Floris , Zhao Yongqiang
Published: February 2023

We give an explicit minimal graded free resolution, in terms of representations of the symmetric groupSd{S_{d}}, of a Galois-theoretic configuration ofdpoints in𝐏d-2{\mathbf{P}^{d-2}}that was studied by Bhargava in the context of ring parametrizations. When applied to the geometric generic fiber of a simply branched degreedcover of𝐏1{\mathbf{P}^{1}}by a relatively canonically embedded curveC, our construction gives a new interpretation for the splitting types of the syzygy bundles appearing in its relative minimal resolution. Concretely, our work implies that all these splitting types consist of scrollar invariants of resolvent covers. This vastly generalizes a prior observation due to Casnati, namely that the first syzygy bundle of a degree 4 cover splits according to the scrollar invariants of its cubic resolvent. Our work also shows that the splitting types of the syzygy bundles, together with the multi-set of scrollar invariants, belong to a much larger class of multi-sets of invariants that can be attached toC→𝐏1{C\to\mathbf{P}^{1}}: one for each irreducible representation ofSd{S_{d}}, i.e., one for each partition ofd.
On the existence of nonnegative radial solutions for Dirichlet exterior problems on the Heisenberg group
Authors: Jleli Mohamed
Published: February 2023

We investigate the existence and nonexistence of nonnegative radial solutions to exterior problems of the form

Δ

H

m

u

(

q

)

+
λ
ψ

(

q

)

K

(

r

(

q

)

)

f

(

r

2
−
Q

(

q

)

,
u

(

q

)

)

=
0

{\Delta }_{{{\mathbb{H}}}^{m}}u\left(q)+\lambda \psi \left(q)K\left(r\left(q))f\left({r}^{2-Q}\left(q),u\left(q))=0

in

B

1

c

{B}_{1}^{c}

, under the Dirichlet boundary conditions

u
=
0

u=0

on

∂

B

1

\partial {B}_{1}

and

lim

r

(

q

)

→
∞

u

(

q

)

=
0

{\mathrm{lim}}_{r\left(q)\to \infty }u\left(q)=0

. Here,

λ
≥
0

\lambda \ge 0

is a parameter,

Δ

H

m

{\Delta }_{{{\mathbb{H}}}^{m}}

is the Kohn Laplacian on the Heisenberg group

H

m

=

R

2
m
+
1

{{\mathbb{H}}}^{m}={{\mathbb{R}}}^{2m+1}

,

m
>
1

m\gt 1

,

Q
=
2
m
+
2

Q=2m+2

,

B

1

{B}_{1}

is the unit ball in

H

m

{{\mathbb{H}}}^{m}

,

B

1

c

{B}_{1}^{c}

is the complement of

B

1

{B}_{1}

, and

ψ

(

q

)

=

∣
z

∣

2

r

2

(

q

)

\psi \left(q)=\frac{| z{| }^{2}}{{r}^{2}\left(q)}

. Namely, under certain conditions on

K

K

and

f

f

, we show that there exists a critical parameter

λ

∗

∈

(

0
,
∞

]

{\lambda }^{\ast }\in \left(0,\infty ]

in the following sense. If

0
≤
λ
<

λ

∗

0\le \lambda \lt {\lambda }^{\ast }

, the above problem admits a unique nonnegative radial solution

u

λ

{u}_{\lambda }

; if

λ

∗

<
∞

{\lambda }^{\ast }\lt \infty

and

λ
≥

λ

∗

\lambda \ge {\lambda }^{\ast }

, the problem admits no nonnegative radial solution. When

0
≤
λ
<

λ

∗

0\le \lambda \lt {\lambda }^{\ast }

, a numerical algorithm that converges to

u

λ

{u}_{\lambda }

is provided and the continuity of

u

λ

{u}_{\lambda }

with respect to

λ

\lambda

, as well as the behavior of

u

λ

{u}_{\lambda }

as

λ
→

λ

∗

−

\lambda \to {{\lambda }^{\ast }}^{-}

, are studied. Moreover, sufficient conditions on the the behavior of

f

(

t
,
s

)

f\left(t,s)

as

s
→
∞

s\to \infty

are obtained, for which

λ

∗

=
∞

{\lambda }^{\ast }=\infty

or

λ

∗

<
∞

{\lambda }^{\ast }\lt \infty

. Our approach is based on partial ordering methods and fixed point theory in cones.
Symmetric skew braces and brace systems
Authors: Bardakov Valeriy G. , Neshchadim Mikhail V. , Yadav Manoj K.
Published: February 2023

For a skew left brace

(
G
,
⋅
,
∘
)

{(G,\cdot\,,\circ)}

, the map

λ
:

(
G
,
∘
)

→

Aut
⁡

(
G
,
⋅
)

{\lambda:(G,\circ)\to\operatorname{Aut}(G,\cdot\,)}

,

a
↦

λ
a

,

{a\mapsto\lambda_{a},}

where

λ
a

⁢

(
b
)

=

a

-
1

⋅

(

a
∘
b

)

{\lambda_{a}(b)=a^{-1}\cdot(a\circ b)}

for all

a
,
b

∈
G

{a,b\in G}

,
is a group homomorphism. Then λ can also be viewed as a map from

(
G
,
⋅
)

{(G,\cdot\,)}

to

Aut
⁡

(
G
,
⋅
)

{\operatorname{Aut}(G,\cdot\,)}

, which, in general, may not be a homomorphism. A skew left brace will be called λ-anti-homomorphic (λ-homomorphic) if

λ
:

(
G
,
⋅
)

→

Aut
⁡

(
G
,
⋅
)

{\lambda:(G,\cdot\,)\to\operatorname{Aut}(G,\cdot\,)}

is an anti-homomorphism (a homomorphism). We mainly study such skew left braces. We device a method for constructing a class of binary operations on a given set so that the set with any two such operations constitutes a λ-homomorphic symmetric skew brace. Most of the constructions of symmetric skew braces dealt with in the literature fall in the framework of our construction. We then carry out various such constructions on specific infinite groups.
Non-commutative Khinchine-type inequality for dependent random variables and overview of its applications in data science
Authors: Spektor Susanna
Published: February 2023

We obtained a non-commutative Khinchine-type inequality under assumption that Rademacher random variables are dependent under condition that the sum of them is equal to some integer M.
Solution of the backward problem for the space-time fractional diffusion equation related to the release history of a groundwater contaminant
Authors: Salehi Shayegan Amir Hossein , Zakeri Ali , Salehi Shayegan Adib
Published: February 2023

Finding the history of a groundwater contaminant plume from final measurements is an ill-posed problem and, consequently, its solution is extremely sensitive to errors in the input data. In this paper, we study this problem mathematically. So, firstly, existence and uniqueness theorems of a quasi-solution in an appropriate class of admissible initial data are given. Secondly, in order to overcome the ill-posedness of the problem and also approximate the quasi-solution, two approaches (computational and iterative algorithms) are provided. In the computational algorithm, the finite element method and TSVD regularization are applied. This method is tested by two numerical examples. The results reveal the efficiency and applicability of the proposed method. Also, in order to construct the iterative methods, an explicit formula for the gradient of the cost functional J is given. This result helps us to construct two iterative methods, i.e., the conjugate gradient algorithm and Landweber iteration algorithm. We prove the Lipschitz continuity of the gradient of the cost functional, monotonicity and convergence of the iterative methods.
At the end of the paper, a numerical example is given to show the validation of the iterative algorithms.
ALG11-CDG: novel variant and review of the literature
Authors: Erdal Ayşenur Engin , Ceylan Ahmet Cevdet , Gücüyener Kıvılcım , Öktem Rıdvan Murat , Kıreker Köylü Oya , Kasapkara Çiğdem Seher
Published: February 2023

Objectives

Asparagine-dependent glycosylation 11-congenital disorders of glycosylation (ALG11-CDG) is a rare autosomal recessive N-glycosylation defect with multisystem involvement particularly neurological symptoms such as epilepsy and neuromotor developmental delay.

Case presentation

A 31-month-old male patient admitted to our center with complaints of axial hypotonia, drug-resistant myoclonic seizures, microcephaly and deafness. The electroencephalography (EEG) showed a burst-suppression pattern without hypsarrhythmia. Basal metabolic investigations were unremarkable. Progressive cerebral atrophy, hypomyelination and corpus callosum hypoplasia were striking features in brain MRI images taken during our follow-up. Compound heterozygous mutations of the ALG11 gene were found by whole exome sequencing (WES) analysis. It was determined that the c.476T>C mutation is a novel mutation. CDG type 1 pattern was detected with the examination of carbohydrate-deficient transferrin (CDT) by capillary zone electrophoresis.

Conclusions

In patients with a possible congenital defect of glycosylation, a screening test such as CDT analysis is suggested. To discover novel mutations in this rare disease group, expanded genetic analysis should be performed.
Language Logicality: New Evidence in Favour of theRescaleApproach?
Authors: Coleschi Giada
Published: February 2023

What is the relationship between syntax and logic? Is the former autonomous and independent of the latter? If it is not, what kind of logic syntax interfaces with? These questions are not unheard of, having been around for quite some time, along with different answers. In the generative tradition, for example, logic cannot provide a model for linguistic behaviour. Conversely, according to the logicality of language hypothesis logical considerations are relevant to syntactic formation and explain the ungrammaticality of certain constructions. This note offers a brief overview of the logicality of language hypothesis and proposes new evidence that seems to indicate that accepting the said hypothesis does not necessarily require assuming a “natural” logic.
Torture and Trolleys: Accepting the Nearly Absolute Wrongness of Philanthropic Torture of a Perpetrator
Authors: Jensen David
Published: February 2023

One potentially morally justified use of torture is found in philanthropic torture of a perpetrator (PTP): scenarios in which a perpetrator has instigated significant pending suffering against innocents and in which the suffering can be prevented by means of the perpetrator’s cooperation. These situations involve a clash of two intuitions: that torture is in some strong and obvious sense absolutely morally wrong, and that torture or harm of an immoral perpetrator may be permissible to prevent equally abhorrent, if not greater, moral wrongs. My view is that a dually grounded view—permissible on theoretical grounds but wrong on practical grounds—can do justice to the conflicting intuitions we have about torture in cases of PTP. Further, I hold that practical “absolutism” will only be “mostly” or “likely” absolute, but that we should accept as adequate this “near absolutism”—it will give us the practical result we seek while also satisfying the intuition that we may act in otherwise untoward ways to prevent horrific moral harms.
FTIR conformity analysis and performance testings of fresh, aged and expired polymeric paints under different storage conditions
Authors: Abd Rashid Norsyazlin , Salim Yoga Sugama , Abdul Halim Suhaila Idayu , Harun Mohamad Kamal , Ong Chong Hup , Chan Chin Han
Published: February 2023

This study aims to correlate the molecular structure consistency of unmixed paints and the performance of 2-pack three-layer protective dried coatings (mixed and cured paints) in various aging conditions (fresh, aged and expired paints) stored under different conditions. All the physical tests (density, solid content, viscosity and sag resistance) of paints fulfil the required specifications. However, these tests cannot tell if the chemical formulation of retained paints (aged and expired) has undergone changes due to storage. The conformity analysis by Fourier-transform infrared (FTIR) spectroscopy coupled with squared derivative algorithm was employed for molecular structure analysis comparison of the fresh and retained paints. FTIR results show high degree of similarity (r), with r ≥ 0.900 for the properly stored retained paints when compared against its fresh paints using high sensitivity compare algorithm. This finding is validated with a paired Student’s t-test and it turns out that the r values of properly stored paints are not statistically different from the fresh paints. Moreover, the performance test (pull off adhesion and salt-spray) of dried coatings indicates good durability when the properly stored retained paints with high degree of structural similarity are applied on the substrate according to end user specifications. This approach offers a practical solution for the paint manufacturer and user to employ a rapid and non-destructive FTIR structural analysis for the confirmation of structural consistency of retained paints before application instead of disposing the polymeric paint without verification.
A framework for integrating safety and environmental impact in the conceptual design of chemical processes
Authors: Tahmid Mohammed , Syeda Sultana Razia
Published: February 2023

Multiple factors influence chemical process design and technology selection, including technical, economic, environmental, and safety considerations. Traditionally, a techno-economic analysis has been used to select a base case design, while safety and environmental impact have been subsequently assessed. This may leave out designs that exhibit better environmental and safety performance than the selected base case at a very early stage of design, where abundant opportunities for incorporating these objectives are present. Furthermore, although safety is an integral part of the overall sustainability of a chemical plant, historically it has been addressed separately from sustainability. Thus, there is a growing awareness for simultaneous consideration of these objectives during the conceptual process design phase of a project in order to select the most sustainable process route. The key to an effective sustainability assessment method for selecting the most sustainable process route involves the parsimonious selection of adequate metrics which define the sustainability profile of the process and an integrated multi-criteria decision-making (MCDM) framework. In this context, this work investigates gaps in conceptual process design and existing sustainability assessment methods through a review of existing environmental impact and safety assessment methodologies/tools. A possible workflow that incorporates both safety and environmental impact in a holistic multi-criterion decision-making framework (MCDM) has been proposed to select the most sustainable process route. The use of this framework is illustrated through a simple case study involving assessing solvent alternatives for palm oil recovery to highlight the scope and significance of the proposed framework.
Genetic dissection of the Mastl-Arpp19/Ensa-PP2A-B55δ pathway in mammalian cells
Authors: Diril Muhammed Kasim , Erguven Mehmet
Published: February 2023

Objectives

Mastl is an essential kinase required for inhibition of the phosphatase activity directed toward Cdk1/cyclin B substrates during mitosis. Mastl phosphorylates two small evolutionarily conserved proteins, Arpp19 and Ensa converting them into strong inhibitors of PP2A-B55δ. Mastl-Arpp19/Ensa-PP2A regulatory pathway has been mainly studied in Xenopus egg extracts and Drosophila using biochemical and genetic approaches. Studies in mammalian cells and genetically modified mouse models have suggested distinct but important functions for Arpp19 and Ensa, in mitosis and S-phase, respectively. A detailed comparative analysis of the Arpp19 and Ensa functions in mammalian cells has not been performed.

Methods

We utilized Mastl conditional knockout (CKO) mouse embryonic fibroblasts (MEF), to investigate the roles of Mastl-Arpp19/Ensa-PP2A pathway components in mitosis and cellular proliferation. We used viral transduction for overexpression or silencing of these genes in conjunction with inducible genetic Mastl knockout to assess their roles in relation to each other.

Results

We show that, Arpp19 is expressed at significantly higher levels in MEFs in comparison to Ensa. Silencing of Arpp19, but not Ensa, results in reduced cellular proliferation. Overexpression of WT Arpp19 or its phosphomimetic mutant (S67D) partially restores mitosis arrest duration in Mastl knockout MEFs, however cellular proliferation block cannot be rescued. Silencing of B55δ expression has a similar outcome as Arpp19 overexpression, underscoring the opposite roles of these genes in mitosis.

Conclusions

Our results show that Arpp19 is the major Mastl substrate during mitotic division of MEFs. Ensa expression is low and it is not essential for cell cycle.
Supersonic jet mixing in the presence of two annular co-flow streams
Authors: S Rajkumar , Vasanthakumar Parthasarathy , Suseela Moorthi Aravindh Kumar , Rathakrishnan Ethirajan
Published: February 2023

The mixing characteristics of a Mach 1.9 jet at three levels of overexpansion, corresponding to nozzle pressure ratio (NPR) 3, 4 and 5, in the presence of a sonic co-flow (secondary flow), which was submerged in a subsonic co-flow (tertiary flow) was studied experimentally. For these NPRs the secondary co-flow is sonic with underexpanded levels and the tertiary flow Mach number was found to be 0.41, 0.71 and 0.85, respectively. The centerline decay results of the primary jet show that the jet mixing is abated by the co-flow, at all levels of expansion. However, in spite of the reduced mixing encountered by the supersonic primary jet, the waves in the jet core are found to be weaker in the presence of co-flows. This may be regarded as an advantage from the shock associated noise point of view, in accordance with Tam’s theory; which states weaker the waves in the core, the lesser is the shock associated noise. The results show that the reduced mixing environment caused by the sonic co-flow alone leads to the jet core elongation of about 20%, 23% and 49%, at NPRs 3, 4 and 5, respectively. The core length of the jet is found to increase by 29%, 46% and 62%, respectively, at NPRs 3, 4 and 5, when both sonic and subsonic co-flow streams are present.
EXTRACTION OF BIOACTIVE COMPOUNDS FROM FENUGREEK LEAVES BY MACERATION WITH D-OPTIMAL DESIGN
Authors: TÜRKER İzzet , İŞLEROĞLU Hilal
Published: February 2023

In this study, optimum extraction conditions of bioactive compounds from fenugreek leaves (Trigonella-foenum graecum L.) were investigated using response surface methodology and the extracts having the highest total phenolic content, total flavonoid compounds, antioxidant activity and total saponin content were achieved. The independent process variables were solvent mixture ratio (water and ethanol, 0-100%), temperature (25-65°C) and sample–solvent ratio (10-50 g/L), and a constant extraction time of 120 minutes was used for all the design points. The experimental study was arranged according to D-optimal combined design and the process conditions were optimized using desirability function approach. Results showed that the extraction of phenolic compounds and antioxidant activity were increased at increasing water ratios and temperature and decreasing sample-solvent ratio. Saponins were extracted better when 25% ethanol was used as solvent. The optimum extraction conditions were determined as 100% of water, 49.71°C of temperature, and 10 g/L of sample–solvent ratio.
Ambivalent Europeanization in the Western Balkans
Authors: Trošt Tamara P.
Published: February 2023

The drawn-out process of applying for European Union membership has encouraged cynicism in Serbia and other Western Balkan states about the value of becoming part of the bloc. Local elites have instrumentalized the accession process, making a show of superficial compliance with EU conditions while eroding democratic institutions and stoking popular backlashes against EU-mandated protections for minorities. Perceptions that Brussels has turned a blind eye to such behavior have weakened the pro-European camp in the region.
When dysbiosis meets dystrophy: an unwanted gut‐muscle connection
Authors: Jayaraman Anusha , Pettersson Sven
Published: February 2023

Duchenne muscular dystrophy (DMD) is a devastating neuromuscular degenerative disease with no known cure to date. In recent years, the hypothesis of a “gut‐muscle axis” has emerged suggesting that bidirectional communication between the gut microbiota and the muscular system regulates the muscular function and may be perturbed in several muscular disorders. In addition, the excessive consumption of sugar and of lipid‐rich processed food products are factors that further aggravate the phenotype for such diseases and accelerate biological aging. However, these unhealthy microbiota profiles can be reversed by individualized dietary changes to not only alter the microbiota composition but also to reset the production of microbial metabolites known to trigger beneficial effects typically associated with prolonged health span. Two recent studies (in this issue of EMBO Mol Med) highlight the interesting potential of microbiota‐informed next‐generation dietary intervention programs to be considered in genetically linked muscle disorders like DMD.
BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS
Authors: Guo Xiao , Zhu Yuemeng , Guo Lu , Qi Yiwen , Liu Xiaocheng , Wang Jinhui , Zhang Jiangtao , Cui Linlin , Shi Yueyang , Wang Qichu , Liu Cenxi , Lu Guangxing , Liu Yilian , Li Tao , Hong Shangyu , Qin Yingying , Xiong Xuelian , Wu Hao , Huang Lin , Huang He , Gu Chao , Li Bin , Li Jin
Published: February 2023

Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle‐stimulating hormone. Though POI affects many aspects of women's health, its major causes remain unknown. Many clinical studies have shown that POI patients are generally underweight, indicating a potential correlation between POI and metabolic disorders. To understand the pathogenesis of POI, we performed metabolomics analysis on serum and identified branch‐chain amino acid (BCAA) insufficiency‐related metabolic disorders in two independent cohorts from two clinics. A low BCAA diet phenotypically reproduced the metabolic, endocrine, ovarian, and reproductive changes of POI in young C57BL/6J mice. A mechanism study revealed that the BCAA insufficiency‐induced POI is associated with abnormal activation of the ceramide‐reactive oxygen species (ROS) axis and consequent impairment of ovarian granulosa cell function. Significantly, the dietary supplement of BCAA prevented the development of ROS‐induced POI in female mice. The results of this pathogenic study will lead to the development of specific therapies for POI.
APLIKASI DETEKSI DINI COVID-19
Authors: Cahyati Widya Hary , Fauzi Lukman , Nugroho Efa , Maulidah Heni , Fatmasari Annisa Putri , Mazidah Nurkhaqiqotul , Susilowati Ita
Published: February 2023

Kota Semarang mempunyai jumlah kasus positif Covid-19 terkonfirmasi per 1 Februari 2022 mencapai 89.390 orang, sedangkan yang meninggal mencapai 6.501 orang. Saat ini sudah ada sistem upaya pemantauan dari pemerintah melalui dinas terkait, namun sistem pemantauan yang fokus pada pemantauan dini faktor risiko dan gejala Covid-19 belum ada, sehingga peneliti ingin membuat sistem pemantauan dini yang dilakukan oleh masyarakat sendiri yang nantinya bisa terkoneksi dengan puskesmas setempat. Tujuan dalam penelitian ini adalah untuk menganalisis efektivitas dan implementasi EDECO-19 (Early Detection of COVID-19) untuk monitoring dini gejala dan faktor risiko covid-19. Penelitian ini merupakan penelitian pengembangan (research and development) untuk menghasilkan sebuah aplikasi yang disebut EDECO-19 (Early Detection of COVID-19) sebagai early warning system dalam monitoring dini gejala dan faktor risiko Covid-19. Sampai saat ini sudah dihasilkan produk EDECO-19, dan sudah diuji coba di masyarakat terbatas, yaitu di wilayah Kecamatan Gunungpati dan Kecamatan Mangkang, Kota Semarang. Hasilnya, produk ini dapat dijalankan dengan baik, mudah digunakan, dan mampu menemukan informasi yang dibutuhkan berkaitam dengan gejala dan faktor risiko Covid-19 di masyarakat. Untuk selanjutnya akan dilakukan pengembangan dengan uji coba ke masyarakat yang lebih luas. Hasil penelitian menunjukkan bahwa EDECO-19 efektif untuk monitoring dini gejala dan faktor risiko covid-19 bagi kader kesehatan desa.
KARAKTERISTIK ASPEK KESEHATAN LINGKUNGAN DAN PERILAKU PASIEN COVID-19 DALAM PELAKSANAAN ISOLASI MANDIRI
Authors: Pawenang Eram Tunggul , Wijayanti Yuni , Siwiendrayanti Arum
Published: February 2023

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) adalah penyebab penyakit baru yang dikenal dengan nama COVID-19. Perpindahan SARS-CoV-2 dapat terjadi melalui singgungan tidak berjarak  dengan orang yang positif terinfeksi, sehingga perlu isolasi mandiri untuk membatasi  kontak. Isolasi mandiri di rumah sangat dianjurkan  untuk individu yang diyakini telah terpapar COVID-19, baik tanpa gejala maupun dengan gejala ringan. Studi ini bertujuan untuk melihat karakteristik segi kesehatan lingkungan, dan tingkah laku pasien isolasi mandiri COVID-19 yang terdata di Puslakes UNNES. Penelitian menggunakan jenis deskriptif kuantitatif dengan menggunakan pendekatan potong lintang. Pemilihan sampel responden menggunakan  total sampling dan di dapatkan  pasien COVID-19 yang melakukan isolasi mandiri sebanyak 73 pasien. Instrumen yang digunakan adalah kuesioner. Penelitian memberikan hasil pada aspek lingkungan menunjukkan fasilitas sanitasi responden mayoritas baik (95,5%), diikuti desinfeksi (76,7%), kamar tidur memenuhi syarat (75,3%), pengelolaan limbah memenuhi syarat (69,9%), dan kamar mandi memenuhi syarat (64,4%). Berdasarkan aspek perilaku, responden dengan perilaku baik sebesar 54,8%, termasuk dalam kategori yang rendah karena yang baik minimal 80%. Terdapat hubungan antara aspek lingkungan desinfeksi dengan perilaku isoman yang baik pada responden yang terdata di Puslakes UNNES (p value 0,016).
POTENSI EKSOPOLISAKARIDA BAKTERI ASAM LAKTAT UNTUK MENCEGAH DAN MENGENDALIKAN DIABETES MELLITUS TIPE 2
Authors: Farida Eko , Lestari Yanesti Nur Avianda , Susilo Mursid Tri , Rachmawati Latifah
Published: February 2023

Bakteri Asam Laktat (BAL) merupakan salah satu potensi indigenus Indonesia yang berhasil diisolasi dari berbagai makanan fermentasi. BAL bersifat menguntungkan di bidang pangan maupun kesehatan. BAL juga memiliki potensi sebagai probiotik dengan berbagai manfaat fungsional bagi tubuh. Studi yang telah dilakukan melaporkan bahwa produk pangan yang difermentasi dengan BAL akan meningkatkan aktivitas antioksidan dan penghambatan terhadap α-glukosidase. Produk pangan dengan kandungan antioksidan tinggi mampu menurunkan inflamasi pada kondisi diabetes mellitus tipe 2 (DMT2) sehingga menurunkan glukosa darah. Salah satu mekanisme penurunan glukosa darah adalah melalui penurunan ekspresi gen pengendali proses glukoneogenesis di hati yaitu gen fosfoenol piruvat karboksikinase (Pepck) dan glucose-6-fosfatase (G6pc). Komponen yang diduga berperan dalam mekanisme penurunan glukosa darah oleh BAL adalah eksopolisakarida (EPS). Eksopolisakarida merupakan metabolit sekunder BAL yang mampu menempel dan berkolonisasi di mukosa usus sehingga menekan pertumbuhan patogen. Tantangan pengembangan BAL sebagai probiotik adalah pada saat komersialisasi produk. BAL harus mudah dikulturkan pada skala besar dan harus bertahan selama proses fermentasi atau pengolahan. BAL harus tetap stabil dan bertahan viabilitasnya di dalam produk selama pemasaran, serta tetap memiliki sifat fungsional sebagai probiotik ketika berada di kolon.
WHEY PROTEIN, DAUN KELOR, KURMA, DAN KELELAHAN OTOT
Authors: Mardiana Mardiana , Rachmawati Latifah , Sari Nadia Puspita , Amien Tsaniatin Nahla Al
Published: February 2023

BCAA merupakan salah satu jenis asam amino yang banyak digunakan pada minuman olahraga atau sport drink. BCAA berperan pada proses metabolisme dan kerja otot, meningkatkan daya tahan pada kapasitas latihan, meningkatkan sintesis protein dan mengurangi kelelahan otot sehingga dapat mempercepat pemulihan nyeri otot. Suplementasi BCAA yang dilakukan pada penelitian sebelumnya memberikan efek berupa penurunan nyeri otot dan kerusakan pada otot yang terjadi pasca latihan. Kemudian sport drink pada penelitian ini dikembangakan dengan menggunakan bahan yang terdapat kandungan protein seperti whey protein, kurma dan daun kelor. Whey protein dalam meningkatkan peforma mempunyai peranan untuk meningkatkan kapasitas aerob, mengoptimalkan pemulihan setelah latihan, pembangun massa otot dan meningkatkan komposisi tubuh. Kemudian asam amino banyak ditemukan di dalam daun kelor salah satunya adalah asam amino esensial yang berguna bagi pertumbuhan dan perbaikan jaringan otot. Selain itu, kurma merupakan bahan pangan yang kaya akan zat gula, vitamin, mineral, dan serat serta berperan sebagai antioksidan. Oleh sebab itu, guna mendeteksi adanya kerusakan jaringan pada otot maka diperlukan kreatin kinase (CK) untuk mengetahui adanya inflamasi pada membran otot skeletal dan otot jantung sehingga mendapatkan penangan khusus untuk pemulihannya.
FAKTOR YANG MEMPENGARUHI PENGELOLAAN LIMBAH MASKER PADA MAHASISWA HYBRID LURING DI UNNES TAHUN 2022
Authors: Pawenang‬ ‪Eram Tunggul , Wijayanti Yuni , Siwiendrayanti Arum
Published: February 2023

Masker merupakan limbah sampah yang banyak dihasiIkan seIama masa pandemi Covid-19, mengingat kebijakan dan himbauan pemerintah untuk seIaIu memakai masker. PenuIaran Covid-19 yang dapat menuIar secara tidak Iangsung meIaIui benda yang terkontaminasi dropIet menyebabkan sampah masker harus dikeIoIa dengan baik dan benar, karena dikhawatirkan dapat menjadi media penuIaran Covid-19. PengeIoIaan sampah khususnya masker di kaIangan mahasiswa seIama ini beIum sepenuhnya sesuai dengan metode dan teknik pengeIoIaan sampah yang berwawasan Iingkungan sehingga berdampak negatif bagi kesehatan dan Iingkungan. Jenis dan desain peneIitian ini adaIah peneIitian observasionaI anaIitik dengan pendekatan cross sectionaI, sedangkan teknik pengumpuIan data daIam peneIitian ini diIakukan meIaIui observasi terhadap sampeI peneIitian. PopuIasi peneIitian ini adaIah mahasiswa dari deIapan fakuItas di Universitas Negeri Semarang. HasiI peneIitian ini mengungkapkan bahwa faktor yang mempengaruhi pengeIoIaan sampah mahasiswa UNNES hanya periIaku, sedangkan faktor pengetahuan, sikap, ketersediaan fasiIitas dan dukungan keIuarga tidak mempengaruhi pengeIoIaan sampah masker oIeh mahasiswa UNNES.
The effect of treating pine regular kraft pulp with peracetic acid before O2-delignification on the consumption of ClO2 in D0ED1 bleaching
Authors: Danielewicz Dariusz
Published: February 2023

Effects of pre-treating pine kraft pulp kappa number 31.5 with peracetic acid (Paa) (0.33% and 0.66% as active oxygen based on oven-dried pulp) before O2-delignification were studied relative to the consumption of chlorine dioxide in a subsequent Elemental Chlorine Free (ECF) bleaching process. The study showed that such pre-treatment is an effective way to extend the delignification of the pine pulp and to reduce the consumption of chlorine dioxide required to bleach the pulp to a brightness of 87%. The reduction in chlorine dioxide required to bleach the pine pulp depended on the amount of Paa used for pre-treatment. Furthermore, the research showed that decreasing the kappa number of the pine pulp to approximately 7.5 units (with Paa pre-treatment and lengthening of O2-delignification process) caused an over-proportional reduction (by approximately 62.5%) in chlorine dioxide consumption to bleach the pulp to 87% brightness.
Eosinophilic Granulomatosis with Polyangiitis in an 8-year-old Girl Manifesting as Hypereosinophilic Syndrome with Myocarditis, Stroke, and Subsequent Orbital Involvement
Authors: Paņina Aleksandra , Ligere Elīna , Aleksejeva Elīna , Davidsone Zane , Cebura Elizabete , Erdmane Irina
Published: February 2023

Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by peripheral blood eosinophilia of 1.5 × 109/L (1,500/μL) or greater, with evidence of end-organ damage attributable to eosinophilia (e.g., heart, liver or lung) with no other cause for the end-organ damage [1]. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disorder that may affect multiple organ systems (lungs, heart, kidneys, or the nervous system). The disorder is characterized by hypereosinophilia in the blood and tissues, inflammation of blood vessels (vasculitis), and the development of inflammatory nodular lesions called granulomatosis [2]. We report a case with a 9-year-old girl presenting with severe hypereosinophilia, ischemic stroke, right-sided hemiparesis and myocarditis treated with methylprednisolone, enoxaparin, rivaroxaban and carvedilol. The patient recovered successfully from myocarditis and stroke but manifested with right-sided orbital involvement as pre- and post-septal orbital cellulitis 10 months later with necrotizing granulomatous perivascular chronic infiltration with eosinophilic infiltration treated with methylprednisolone and subsequent mepolizumab with successful remission of orbital involvement, but severe exogenous Cushing’s syndrome and myocardial fibrosis.
Istoriniai pasakojimai Lietuvos periodinėje spaudoje lietuvių kalba 1904–1944 m
Authors:   , Krutulys Titas
Published: February 2023

Historical narratives in the Lithuanian periodical press in Lithuanian language from 1904 to 1944
O verdadeiro desafio do TikTok
Authors: Coelho Renato Arnellas
Published: February 2023

O homem, pela sua própria natureza, busca diversos meios de interação social ao longo de sua vida. Recentemente, o crescente número de usuários do aplicativo TikTok não passa desapercebido pela Igreja que vê em tudo uma oportunidade para evangelizar. A cada nova geração é missão da Igreja transmitir o evangelho às novas pessoas que chegam a este mundo. No contexto atual, as gerações mais jovens estão cada vez mais conectadas nas redes sociais e, após a pandemia de 2020, muitos jovens aderiram ao uso do aplicativo TikTok como meio de entretenimento pessoal e de interação social para aliviar as tensões geradas pela situação atípica de isolamento generalizado. Apesar do TikTok não ter sido criado como meio de evangelização, mas de diversão, cabe à Igreja vencer esse verdadeiro desafi o e conseguir com sua fecunda criatividade transmitir sua mensagem nesses novos locais em que as pessoas se encontram, precisando para isso conhecer melhor seus potenciais e limitações, bem como fugir de eventuais perigos que as novas tecnologias podem apresentar. Para tanto, certos princípios e orientações já tratados no documento de Medellín podem ajudar a fornecer pistas para esse novo meio de comunicação social chamado TikTok.
Kriegsnarrative in reichsbürgerlichen Texten – Inszenierungen des Ausnahmezustandes
Authors: Schuppener Georg
Published: February 2023

This article deals with the topic of war in selected texts written by Reich citizens. It begins by outlining the current state of research, revealing a notable gap in our knowledge – particularly with regard to the linguistic specifics of Reich citizens’ texts. Texts from the organization “Bismarcks Erben” (“Bismarck’s Heirs”) are then examined in more detail. For this purpose, a statistical evaluation of the lexis is carried out. It can be shown that war lexis is an important component of these texts. Furthermore, the role of war narratives for the self-representation and recruitment of Reich citizens is examined.
[Es] interessierte mich schon einiges, was der Fürst niedergeschrieben hatte. Die Darstellung des Fürsten Karl Max Lichnowsky im literarischen Schaffen von August Scholtis
Authors: Zlá Iveta
Published: February 2023

The article explores the literary depiction of Prince Karl Max Lichnowsky in the autobiographical novel ‘Ein Herr aus Bolatitz’ by August Scholtis. Attention is paid to the comparison of literary form with the historical reality. An account of Prince Karl Max Lichnowsky’s diplomatic career is embedded into an overview of Scholtis’s biography and literary work. Attention is also paid to the literary representation of Lichnowsky in other works by Scholtis. However, the information on Prince Karl Max Lichnowsky’s diplomatic career is presented only briefly; the main focus is the literary portrayal of this nobleman in the autobiographical text ‘Ein Herr aus Bolatitz’. This is presented in a hermeneutic framework. The study also outlines literary means of representation and their composition.
Unterricht des Deutschen als zweite Fremdsprache aus der Perspektive der Sprachenpolitik und der Schüler*innen
Authors: Janík Miroslav , Janíková Věra
Published: February 2023

Our study focuses on expiring relationships between language policy in the educational context and the users of foreign languages (i.e. pupils). The theoretical part of the study introduces the term language policy and indicates its development in the Czech Republic over the recent years. The empirical part aims to describe how the pupils perceive the German language. Methodologically, we use qualitative analysis of language portraits and interviews. The research sample consists of 25 students (8th grade). Our results show the instrumentalized function of the German language and focus on the usage of the German language. Based on our results, we suggest some changes in language policy that would better fit pupils’ perceptions of languages.
Peter Handke: Algunos conceptos fundamentales en relación con las Artes Plásticas
Authors: Meana Martínez Juan Carlos
Published: February 2023

Este escrito es un acercamiento a algunos conceptos de la producción literaria de Peter Handke. A lo largo de su trabajo, Handke se apoya en imágenes y procedimientos pictóricos para lograr una mirada literaria. El presente ensayo sobre el escritor y su relación con las artes plásticas gira en torno a conceptos como el paisaje, el tiempo, la transformación, las cosas, la mirada y el conocimiento, además de otros temas que aportan datos sobre su idea del arte, como son las relaciones topográficas, la ausencia, la ética del creador, el «des-poder» y otros. Asimismo, se han tomado estos conceptos como modelo para entender el desarrollo de las artes plásticas. Como metodología, la reflexión se ha basado en las lecturas de varios textos de Handke, en paralelo a la creación de algunas obras plásticas por nuestra parte.
Seguimiento a personas graduadas y egresadas universitarias: consideraciones y recomendaciones para su gestión
Authors: Alpízar-Rojas Harlen , Marín Villalobos Roberto , Baltodano-Chacón Mauren , Marín-Picado Bradly
Published: February 2023

El seguimiento a las personas egresadas y graduadas de carreras a nivel universitario está poco desarrollado en Latinoamérica, pero día a día toma más fuerza con otros procesos como lo son la autoevaluación y acreditación. Más allá de eso, la mejora continua en la educación superior surge como un nuevo paradigma que busca responder al cambio constante de la realidad laboral a la que se insertan los y las nuevas profesionales, en el que la retroalimentación que pueden dar quienes se han egresado y graduado de las carreras se convierte en insumo esencial para tal objetivo. Por ello, este artículo plantea, a partir de la experiencia de las Carreras de Psicología y Enseñanza de la Psicología de la Universidad de Costa Rica, una serie de consideraciones y recomendaciones que deberían tomarse en cuenta para la adecuada gestión del seguimiento a esta población. El presente artículo busca ser una guía para las carreras en proceso de mejora continua que deben realizar seguimiento a personas graduadas y egresadas; presentando desde las principales variables que deberían de tomar en cuenta para su adecuado desarrollo hasta las precauciones a considerar para que el proceso tenga un buen curso.
Teaching retirees life adjustment pattern for lifelong educational service delivery in Rivers State, Nigeria
Authors: Eseyin Emmanuel Olorunleke , Eseyin Chisom Ure
Published: February 2023

Every year, several teachers retire from the education sector in Rivers State and these teaching retirees still have a lot they can contribute to the education system but can only deliver lifelong educational services when life after retirement is patterned to what is obtainable during active service. The study investigated teaching retirees' life adjustment pattern for lifelong educational service delivery in Rivers State. The study's design was descriptive survey and 18,073 retirees formed the population of the study out of which 391 retirees were sampled through multistage sampling. Data were collected using questionnaire which was face and content validated by experts in University of Port Harcourt with a Cronbach alpha determined reliability index of 0.94. Answers were provided to the research questions using mean score and SD while at 5% level of significance the hypotheses were tested using z-test statistics. The study revealed that retired teachers adjust economically using different patterns including engaging in paid employment. The retirees also adjusted socially through different patterns. Conclusively, the study identified that the retirees had economic and social adjustment patterns needed for providing lifelong educational services in Rivers State.
Intermittent cold exposure upregulates regulators of cardiac mitochondrial biogenesis and function in mice
Authors: Mohan Mithra Sudha , Sreedevi Aswani Sukumaran , Sakunthala Aparna Nandakumaran , Boban Puthenpura T. , Sudhakaran Perumana R. , Kamalamma Saja
Published: February 2023

Hypothermic conditions enhance the incidence of cardiovascular diseases due to increased blood pressure. Cold-induced adaptive thermogenesis increased mitochondrial biogenesis and function in skeletal muscles and adipocytes. Here, we studied the effect of intermittent cold exposure on the regulators of cardiac mitochondrial biogenesis, function, and its regulation by SIRT-3. Intermittent cold exposed mice hearts showed normal histopathology with increased mitochondrial antioxidant and metabolic function, as evidenced by an increase in the activity and expression of MnSOD and SDH. A substantial increase in mitochondrial DNA copy number and increase in the expression of PGC-1α and its downstream targets NRF-1 and Tfam indicated the possibility of enhanced cardiac mitochondrial biogenesis and function on intermittent cold exposure. Increased mitochondrial SIRT-3 level and decreased total protein lysine acetylation indicate increased sirtuin activity in cold exposed mice hearts. Ex vivo cold mimic using norepinephrine showed a significant increase in PGC-1α, NRF-1, and Tfam levels. AGK-7, a SIRT-3 inhibitor, reversed the norepinephrine-induced upregulation of PGC-1α and NRF-1, indicating the role of SIRT-3 on the production of PGC-1α and NRF-1. Inhibition of PKA with KT5720 in norepinephrine treated cardiac tissue slices indicates the role of PKA in regulating the production of PGC-1α and NRF-1. In conclusion, intermittent cold exposure upregulated the regulators of mitochondrial biogenesis and function through PKA and SIRT-3 mediated pathway. Our results emphasize the role of intermittent cold-induced adaptive thermogenesis in overcoming chronic cold-induced cardiac damage.
Collaboration: The key to managing discipline in South African schools
Authors: Padayachee Amy Sarah , Gcelu Ntombizandile
Published: February 2023

South African schools are faced with an arguably insurmountable problem as a culture of indiscipline continually increases in schools. Despite being undeterred by the legal framework that guides stakeholders in the discipline crisis in schools, indiscipline in schools has soared to critical levels. Scant literature exists on how stakeholders collaborate in managing discipline in schools. The research reported on here was guided by the primary research question: How do stakeholders collaborate in managing discipline in schools? As such, in this article we explore how stakeholders collaborate in managing discipline in schools. Through purposive sampling, 16 participants from 4 secondary schools in KwaZulu-Natal were chosen to take part in semi-structured interviews. The sample of participants comprised school management team members (SMT); the principal, 1 head of department, 1 post-level 1 educator and 1 school governing body (SGB) member from 4 schools in the iLembe education district. Themes that emerged from the data include that implementation of the school code of conduct as one of the most effective strategies in managing discipline in schools. The inclusion of stakeholders such as the local community, the Community Police Forum, the South African Police Services and the Department of Social Development in the successful management of learner discipline surfaced as an important theme. Furthermore, participants asserted that a whole-school approach to the implementation of the code of conduct was successful in managing discipline. The participants revealed that the collaboration of stakeholders in schools was very important for the smooth running of the school, including the management of discipline.
Teachers as curriculum leaders in secondary schools in Vhembe district, South Africa
Authors: Bessong Rebecca , Ogina Teresa
Published: February 2023

In the study reported on here we investigated how teachers exercised their role as curriculum leaders in secondary schools in South Africa. The study was conducted in 4 schools (2 semi-urban and 2 rural) in the Vhembe district of South Africa. Semi-structured individual interviews, focus-group discussions (FGDs), and lesson and meeting observations were used to generate data from 20 teachers. This study was framed within Grant’s (2012) model of teacher leadership. We engaged an exploratory multiple-case study, and 20 teachers were purposively and conveniently sampled. The findings reveal that teachers executed their role as curriculum leaders through engagement in instructional, school-based curriculum development (SBCD) for curriculum implementation and curriculum activities in the schools and in the communities. From the outcome we recommend the provision of sufficient resources and infrastructure to enhance learner-centred pedagogy, thus maximising learner’s learning.