bluuebunny/crossref_metadata_2025 huggingface dataset:
Artificial Neural Network for Predicting the Safe Temporary Artery Occlusion Time in Intracranial Aneurysmal Surgery
Authors: Shahjouei Shima , Ghodsi Seyed Mohammad , Zangeneh Soroush Morteza , Ansari Saeed , Kamali-Ardakani Shahab
Published: April 2021

Background. Temporary artery clipping facilitates safe cerebral aneurysm management, besides a risk for cerebral ischemia. We developed an artificial neural network (ANN) to predict the safe clipping time of temporary artery occlusion (TAO) during intracranial aneurysm surgery. Method. We devised a three-layer model to predict the safe clipping time for TAO. We considered age, the diameter of the right and left middle cerebral arteries (MCAs), the diameter of the right and left A1 segment of anterior cerebral arteries (ACAs), the diameter of the anterior communicating artery, mean velocity of flow at the right and left MCAs, and the mean velocity of flow at the right and left ACAs, as well as the Fisher grading scale of brain CT scans as the input values for the model. Results. This study included 125 patients: 105 patients from a retrospective cohort for training the model and 20 patients from a prospective cohort for validating the model. The output of the neural network yielded up to 960 s overall safe clipping time for TAO. The input values with the greatest impact on safe TAO were mean velocity of blood at left MCA and left ACA, and Fisher grading scale of brain CT scan. Conclusion. This study presents an axillary framework to improve the accuracy of the estimated safe clipping time interval of temporary artery occlusion in intracranial aneurysm surgery.
Determinants of In-Hospital Mortality in Elderly Patients Aged 80 Years or above with Acute Heart Failure: A Retrospective Cohort Study at a Single Rural Hospital
Authors: Watanabe Yusuke , Tajiri Kazuko , Nagata Hiroyuki , Kojima Masayuki
Published: April 2021

Heart failure is one of the leading causes of mortality worldwide. Several predictive risk scores and factors associated with in-hospital mortality have been reported for acute heart failure. However, only a few studies have examined the predictors in elderly patients. This study investigated determinants of in-hospital mortality in elderly patients with acute heart failure, aged 80 years or above, by evaluating the serum sodium, blood urea nitrogen, age and serum albumin, systolic blood pressure and natriuretic peptide levels (SOB-ASAP) score. We reviewed the medical records of 106 consecutive patients retrospectively and classified them into the survivor group (n = 83) and the non-survivor group (n = 23) based on the in-hospital mortality. Patient characteristics at admission and during hospitalization were compared between the two groups. Multivariate stepwise regression analysis was used to evaluate the in-hospital mortality. The SOB-ASAP score was significantly better in the survivor group than in the non-survivor group. Multivariate stepwise regression analysis revealed that a poor SOB-ASAP score, oral phosphodiesterase 3 inhibitor use, and requirement of early intravenous antibiotic administration were associated with in-hospital mortality in very elderly patients with acute heart failure. Severe clinical status might predict outcomes in very elderly patients.
In the Arms of Morpheus without Morphia; Mitigating the United States Opioid Epidemic by Decreasing the Surgical Use of Opioids
Authors: Boretsky Karen , Mason Keira
Published: April 2021

The opioid epidemic is a major public health issue in the United States. Exposure of opioid naïve-patients to opioids in the perioperative period is a well-documented source of continued use with one in 20 opioid-naïve surgical patients continuing to use opioids beyond 90 days. There is no association with magnitude of surgery, major versus minor, and the strongest predictor of continued use is surgical exposure. Causal factors include over reliance on opioids for intraoperative and postoperative analgesia and excessive ambulatory opioid prescribing. Opioid-induced hyperalgesia can paradoxically result from intraoperative (anesthesia controlled) opioid administration. Increasing size of initial prescription is a strong predictor of continued use necessitating procedure specific supplies limited to under 3-days. Alternative multimodal pain management (non-opioid medications and regional anesthesia) that limit opioid use must be a high priority with opioids reserved for severe breakthrough pain. Barriers to implementation of opioid-sparing pathways include reluctance to adopt protocols and apprehension about opioid elimination. Considering the number of surgeries performed annually in the United States, perioperative physicians must aggressively address modifiable factors in surgical patients. Patient care pathways need to be constructed collaboratively by surgeons and anesthesiologists with continuing feedback to optimize patient outcomes including iatrogenic opioid dependence.
The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment—A Narrative Review
Authors: Kryszkowski Waldemar , Boczek Tomasz
Published: April 2021

Schizophrenia is a severe neuropsychiatric disease with an unknown etiology. The research into the neurobiology of this disease led to several models aimed at explaining the link between perturbations in brain function and the manifestation of psychotic symptoms. The glutamatergic hypothesis postulates that disrupted glutamate neurotransmission may mediate cognitive and psychosocial impairments by affecting the connections between the cortex and the thalamus. In this regard, the greatest attention has been given to ionotropic NMDA receptor hypofunction. However, converging data indicates metabotropic glutamate receptors as crucial for cognitive and psychomotor function. The distribution of these receptors in the brain regions related to schizophrenia and their regulatory role in glutamate release make them promising molecular targets for novel antipsychotics. This article reviews the progress in the research on the role of metabotropic glutamate receptors in schizophrenia etiopathology.
The Ophthalmology Surgical Competency Assessment Rubric for Intravitreal Injections (ICO-OSCAR:IVI)
Authors: Kiew Sieh Yean , Yeo Ian Yew San , Golnik Karl C , Muriel-Herrero María A , Fuertes-Barahona Vanesa , Grzybowski Andrzej
Published: April 2021

(1) Background: Intravitreal injections (IVIs) are the most commonly performed intraocular procedure worldwide. Ensuring correct learning is essential to avoid complications. Our purpose was to develop an internationally valid tool to assess skill in performing IVIs. (2) Methods: A panel of six content experts designed a rubric for assessing the IVI procedure by using a modified Dreyfus scale of skill acquisition, dividing it into steps and providing objective behavioral descriptors for each level of skill in each category, following the International Council of Ophthalmology (ICO) guidance. The rubric draft was then critically reviewed by 12 international content experts, and their constructive comments were considered for the final rubric. (3) Results: The Ophthalmology Surgical Competency Assessment Rubric for IVI (ICO-OSCAR:IVI) is the proposed tool for assessing healthcare professionals training to perform IVI. (4) Conclusions: The ICO-OSCAR:IVI is the result of the consensus of an international expert panel. The methodology used for its development provides this rubric with face and content validity. It can be used globally to assess healthcare professionals training to perform IVI, as well as the impact of different teaching methods on performance. Further studies are required to establish intra- and inter-rater reliability, as well as the predictive validity of this tool.
Parenchymal Sparing Resection: Options in Duodenal and Pancreatic Surgery
Authors: Marchese Ugo , Tzedakis Stylianos , Abou Ali Einas , Turrini Olivier , Delpero Jean-Robert , Coriat Romain , Fuks David
Published: April 2021

Parenchymal sparing duodenal and pancreatic resection are safe procedures in selected patients with the aim to reduce endocrine and exocrine long-term dysfunction. When the tumor is benign or borderline malignant, this appears to be a good option for the surgeon, associated with low rates of severe surgery-related early postoperative complications and low in-hospital mortality. This mini review offers comments, tips and tricks, and a review of literature concerning those different options with specific illustrations in order to clarify their indication.
Increased Circulating Malondialdehyde-Modified Low-Density Lipoprotein Level Is Associated with High-Risk Plaque in Coronary Computed Tomography Angiography in Patients Receiving Statin Therapy
Authors: Ichikawa Keishi , Miyoshi Toru , Osawa Kazuhiro , Miki Takashi , Ito Hiroshi
Published: April 2021

Objective: To evaluate the association of serum malondialdehyde low-density lipoprotein (MDA-LDL), an oxidatively modified LDL, with the prevalence of high-risk plaques (HRP) determined with coronary computed tomography angiography (CTA) in statin-treated patients. Methods: This study was a single-center retrospective cohort comprising 268 patients (mean age 67 years, 58% men) with statin therapy and who underwent coronary CTA for suspected stable coronary artery disease. Patients were classified into two groups according to median MDA-LDL level or median LDL-C level. Coronary CTA-verified HRP was defined when two or more characteristics, including positive remodeling, low-density plaques, and spotty calcification, were present. Results: Patients with HRP had higher MDA-LDL (p = 0.011), but not LDL-C (p = 0.867) than those without HRP. High MDA-LDL was independently associated with HRP (odds ratio 1.883, 95% confidential interval 1.082–3.279) after adjustment for traditional risk factors. Regarding incremental value of MDA-LDL for predicting CTA-verified HRP, addition of serum MDA-LDL levels to the baseline model significantly increased global chi-square score from 26.1 to 32.8 (p = 0.010). Conclusions: A high serum MDA-LDL level is an independent predictor of CTA-verified HRP, which can lead to cardiovascular events in statin-treated patients.
A Review on the Usage of Continuous Carbon Fibers for Piezoresistive Self Strain Sensing Fiber Reinforced Plastics
Authors: Scholle Patrick , Sinapius Michael
Published: April 2021

This literature review examines the application of carbon fibers and their reinforced plastics for Self-Strain-Sensing structures and gives an up-to-date overview of the existing research. First, relevant basic experimental approaches that can be found in the literature are presented and discussed. Next, we propose to cluster the available articles into 5 categories based on specimen size and ranging from experiments on bare carbon fiber via impregnated fiber rovings to carbon fiber laminates. Each category is analyzed individually and the potential differences between them are discussed based on experimental evidence found in the past. The overview shows, that the choice of carbon fiber and the specific experimental setup both significantly influence the piezoresistive properties measured in Self-Strain-Sensing carbon fiber reinforced plastics. Conclusively, based on the conclusions drawn from the literature review, we propose a small number of measurements that have proven to be important for the analysis of Self-Strain-Sensing carbon fiber structures.
Unity Is Intelligence: A Collective Intelligence Experiment on ECG Reading to Improve Diagnostic Performance in Cardiology
Authors: Ronzio Luca , Campagner Andrea , Cabitza Federico , Gensini Gian Franco
Published: April 2021

Medical errors have a huge impact on clinical practice in terms of economic and human costs. As a result, technology-based solutions, such as those grounded in artificial intelligence (AI) or collective intelligence (CI), have attracted increasing interest as a means of reducing error rates and their impacts. Previous studies have shown that a combination of individual opinions based on rules, weighting mechanisms, or other CI solutions could improve diagnostic accuracy with respect to individual doctors. We conducted a study to investigate the potential of this approach in cardiology and, more precisely, in electrocardiogram (ECG) reading. To achieve this aim, we designed and conducted an experiment involving medical students, recent graduates, and residents, who were asked to annotate a collection of 10 ECGs of various complexity and difficulty. For each ECG, we considered groups of increasing size (from three to 30 members) and applied three different CI protocols. In all cases, the results showed a statistically significant improvement (ranging from 9% to 88%) in terms of diagnostic accuracy when compared to the performance of individual readers; this difference held for not only large groups, but also smaller ones. In light of these results, we conclude that CI approaches can support the tasks mentioned above, and possibly other similar ones as well. We discuss the implications of applying CI solutions to clinical settings, such as cases of augmented ‘second opinions’ and decision-making.
Binding Costs in Processing Efficiency as Determinants of Cognitive Ability
Authors: Goecke Benjamin , Schmitz Florian , Wilhelm Oliver
Published: April 2021

Performance in elementary cognitive tasks is moderately correlated with fluid intelligence and working memory capacity. These correlations are higher for more complex tasks, presumably due to increased demands on working memory capacity. In accordance with the binding hypothesis, which states that working memory capacity reflects the limit of a person’s ability to establish and maintain temporary bindings (e.g., relations between items or relations between items and their context), we manipulated binding requirements (i.e., 2, 4, and 6 relations) in three choice reaction time paradigms (i.e., two comparison tasks, two change detection tasks, and two substitution tasks) measuring mental speed. Response time distributions of 115 participants were analyzed with the diffusion model. Higher binding requirements resulted in generally reduced efficiency of information processing, as indicated by lower drift rates. Additionally, we fitted bi-factor confirmatory factor analysis to the elementary cognitive tasks to separate basal speed and binding requirements of the employed tasks to quantify their specific contributions to working memory capacity, as measured by Recall−1-Back tasks. A latent factor capturing individual differences in binding was incrementally predictive of working memory capacity, over and above a general factor capturing speed. These results indicate that the relation between reaction time tasks and working memory capacity hinges on the complexity of the reaction time tasks. We conclude that binding requirements and, therefore, demands on working memory capacity offer a satisfactory account of task complexity that accounts for a large portion of individual differences in ability.
Meta-Intelligence: Understanding, Control, and Interactivity between Creative, Analytical, Practical, and Wisdom-Based Approaches in Problem Solving
Authors: Sternberg Robert J. , Glaveanu Vlad , Karami Sareh , Kaufman James C. , Phillipson Shane N. , Preiss David D.
Published: April 2021

A deeper understanding of the processes leading to problem framing and behind finding solutions to problems should help explain variability in the quality of the solutions to those problems. Using Sternberg’s WICS model as the conceptual basis of problem solving, this article discusses the relations between creative, analytical, practical, and wisdom-based approaches as bases for solutions to problems. We use a construct of meta-intelligence to encompass understanding, control, and coordination between these constructs. We propose that constraints can act at each of three levels—individual, contextual, and interactive. Individual constraints include the metacomponents (executive processes) that underpin each of the four kinds of solutions. Contextual constraints direct which of the four approaches are preferred under what circumstances. Finally, interactive constraints involve individual and contextual constraints directly impacting each other’s actions. The model of meta-intelligence and its functioning helps to explain the variability in the ways that individuals frame problems and, as a consequence, in the solutions that are found. The model of meta-intelligence also helps explain why some solutions to problems are so much more comprehensive, and often better, than others.
Mismatch Repair Status Characterization in Oncologic Pathology: Taking Stock of the Real-World Possibilities
Authors: Piciotti Roberto , Venetis Konstantinos , Sajjadi Elham , Fusco Nicola
Published: April 2021

The mismatch repair (MMR) system has a key role in supporting the DNA polymerase proofreading function and in maintaining genome stability. Alterations in the MMR genes are driving events of tumorigenesis, tumor progression, and resistance to therapy. These genetic scars may occur in either hereditary or sporadic settings, with different frequencies across tumor types. Appropriate characterization of the MMR status is a crucial task in oncologic pathology because it allows for both the tailored clinical management of cancer patients and surveillance of individuals at risk. The currently available MMR testing methods have specific strengths and weaknesses, and their application across different tumor types would require a tailored approach. This article highlights the indications and challenges in MMR status assessment for molecular pathologists, focusing on the possible strategies to overcome analytical and pre-analytical issues.
Social Media’s Impact on the Global Mergers and Acquisitions Market
Authors: Jayasuriya Dulani , O’Neill Ben
Published: April 2021

This study analyses the impact of social media popularity on the global mergers and acquisitions (M&A) market using a sample of 66,905 M&A transactions across 50 countries for the sample period from 2011 to 2017. Social media influence on M&A transactions is tested using competing bids and proportion of cash paid in the transaction deal characteristics. We find that social media popularity has increased the probability of competing bids by 7.7% across countries and the proportion of cash paid in transactions decreased by 2.5% across countries. The results of additional analyses using the introduction of the internet are consistent with the conclusion that technologies that enhance the transmission of public information have an effect on the M&A variables tested. We test the robustness of our results using subsample analysis and placebo tests. This study is distinct from existing literature due to its globally diverse M&A dataset, unique social media and internet data, and cross-country approach to social media’s influence on financial markets.
Localize Animal Sound Events Reliably (LASER): A New Software for Sound Localization in Zoos
Authors: Schneider Sebastian , Dierkes Paul Wilhelm
Published: April 2021

Locating a vocalizing animal can be useful in many fields of bioacoustics and behavioral research, and is often done in the wild, covering large areas. In zoos, however, the application of this method becomes particularly difficult, because, on the one hand, the animals are in a relatively small area and, on the other hand, reverberant environments and background noise complicate the analysis. Nevertheless, by localizing and analyzing animal sounds, valuable information on physiological state, sex, subspecies, reproductive state, social status, and animal welfare can be gathered. Therefore, we developed a sound localization software that is able to estimate the position of a vocalizing animal precisely, making it possible to assign the vocalization to the corresponding individual, even under difficult conditions. In this study, the accuracy and reliability of the software is tested under various conditions. Different vocalizations were played back through a loudspeaker and recorded with several microphones to verify the accuracy. In addition, tests were carried out under real conditions using the example of the giant otter enclosure at Dortmund Zoo, Germany. The results show that the software can estimate the correct position of a sound source with a high accuracy (median of the deviation 0.234 m). Consequently, this software could make an important contribution to basic research via position determination and the associated differentiation of individuals, and could be relevant in a long-term application for monitoring animal welfare in zoos.
Sustainable Rural Development: Strategies, Good Practices and Opportunities
Authors: Masot Ana Nieto , Gascón José Luis Gurría
Published: April 2021

In 2020, a special issue titled “Sustainable Rural Development: Strategies, Good Practices and Opportunities” was launched, in which 16 papers were published [...]
Loss of p16: A Bouncer of the Immunological Surveillance?
Authors: Leon Kelly E. , Tangudu Naveen Kumar , Aird Katherine M. , Buj Raquel
Published: April 2021

p16INK4A (hereafter called p16) is an important tumor suppressor protein frequently suppressed in human cancer and highly upregulated in many types of senescence. Although its role as a cell cycle regulator is very well delineated, little is known about its other non-cell cycle-related roles. Importantly, recent correlative studies suggest that p16 may be a regulator of tissue immunological surveillance through the transcriptional regulation of different chemokines, interleukins and other factors secreted as part of the senescence-associated secretory phenotype (SASP). Here, we summarize the current evidence supporting the hypothesis that p16 is a regulator of tumor immunity.
Performance Assessment of the Post-Tensioned Anchorage Zone Using High-Strength Concrete Considering Confinement Effect
Authors: Lee Jun Suk , Woo Byeong Hun , Ryou Jae-Suk , Kim Jee-Sang
Published: April 2021

Post-tensioned anchorage zones need enough strength to resist large forces from jacking forces from prestress and need spiral reinforcement to give confinement effect. High-strength concrete (HSC) has high-strength and brings the advantage of reducing material using and simplifying reinforcing. We tested strain stabilization, load–displacement, and strain of lateral reinforcements. Specimens that used one and two lateral reinforcements without spiral reinforcement did not satisfy the strain stabilization. Load capacity also did not satisfy the condition of 1.1 times the nominal tensile strength of PS strands presented in ETAG 013. On the other hand, specimens that used three and four lateral reinforcements without spiral reinforcement satisfied the strain stabilization but did not satisfy 1.1 times the nominal tensile strength of PS strands. However, the secondary confinement effect could be confirmed from strain stabilization. In addition, the affection of HSC characteristics could be confirmed from a reinforcing level comparing other studies. The main confinement effect could be confirmed from the reinforcement strain results; there was a considerable difference between with and without spiral reinforcement at least 393 MPa. Comprehensively, main and secondary confinement effects are essential in post-tensioned anchorage zones. In addition, the performance of the anchorage zone could be increased by using HSC that the combination of high-strength and confinement effect.
Microstructure and Durability Performance of Mortars with Volcanic Powder from Calbuco Volcano (Chile) after 4 Hardening Years
Authors: Tremiño Rosa María , Real-Herraiz Teresa , Letelier Viviana , Ortega José Marcos
Published: April 2021

One of the most popular ways to lessen the impact of the cement industry on the environment consists of substituting clinker by additions. The service life required for real construction elements is generally long, so it would be interesting to obtain information about the effects of new additions after a hardening period of several years. Analyzed here are the effects of the incorporation of volcanic ashes, coming from Calbuco volcano’s last eruption (Chile), as clinker replacement, in the durability and pore structure of mortars, after approximately 4 hardening years (1500 days), in comparison with reference specimens without additions. The substitution percentages of clinker by volcanic powder studied were 10% and 20%. The microstructure was characterized with mercury intrusion porosimetry and impedance spectroscopy. In order to evaluate the pozzolanic activity of the volcanic powder after 1500 days, differential thermal analyses were performed. Water absorption after immersion, steady-state diffusion coefficient and length change were also studied. In accordance with the results obtained, the 10% and 20% substitution of clinker by volcanic powder from the Calbuco volcano showed beneficial effects in the mortars after 4 years, especially regarding the microstructure and chloride diffusion, without noticeable influence in their water absorption.
Effects of Copper Surface Oxidation and Reduction on Shear-Bond Strength Using Functional Monomers
Authors: Hiraba Haruto , Koizumi Hiroyasu , Kodaira Akihisa , Takehana Kosuke , Yoneyama Takayuki , Matsumura Hideo
Published: April 2021

This study was conducted to clarify the influence of the copper surface oxidation and reduction on the shear-bond strength with functional monomers. Unheated copper specimens (UH; n = 88) were wet-ground. Three-quarters of the UH were then heated (HT). Two-thirds of the HT was then immersed in a hydrochloric acid solution (AC). Half of the AC was then reheated (RH). Each group was further divided into two groups (n = 11), which were primed by either 6-methacryloyloxyhexyl 2-thiouracil-5-carboxylate (MTU-6) or 10-methacryloyloxydecyl dihydrogen phosphate (MDP). The shear-bond strength tests were used for bonding with an acrylic resin. The surface roughness values and chemical states of the four groups were analyzed using a confocal scanning laser microscope and X-ray photoelectron spectroscopy (XPS). The shear-bond strengths of HT and RH were the lowest in the MTU-6-primed groups. The result of AC was significantly lower than others in the MDP-primed groups. The XPS results showed that the surfaces of UH and AC consisted of Cu2O and Cu. The surface changed to CuO upon heating. The presence or absence of copper-oxide films showed the opposite trends in the effectiveness of MTU-6 and MDP to improve bond strength. The results could elucidate the effects of functional monomers on copper-oxide films.
Electrodeposition of Copper and Brass Coatings with Olive-Like Structure
Authors: Maciej Artur , Łatanik Natalia , Sowa Maciej , Matuła Izabela , Simka Wojciech
Published: April 2021

One method of creating a brass coating is through electrodeposition, which is most often completed in cyanide galvanic baths. Due to their toxicity, many investigations focused on the development of more environmentally friendly alternatives. The purpose of the study was to explore a new generation of non-aqueous cyanide-free baths based on 1-ethyl-3-methylimidazolium acetate ionic liquids. The study involved the formation of copper, zinc, and brass coatings. The influence of the bath composition, cathodic current density, and temperature was determined. The obtained coatings were characterized in terms of their morphology, chemical composition, phase composition, roughness, and corrosion resistance. It was found that the structure of the obtained coatings is strongly dependent on the process parameters. The three main structure types observed were as follows: fine-grained, porous, and olive-like. To the best knowledge of the authors, it is the first time the olive-like structure was observed in the case of an electrodeposited coating. The Cu-Zn coatings consisted of 19–96 at. % copper and exhibited relatively good corrosion resistance. A significant improvement of corrosion properties was found in the case of copper and brass coatings with the olive-like structure.
E-Beam Effects on Poly(Xylitol Dicarboxylate-co-diol Dicarboxylate) Elastomers Tailored by Adjusting Monomer Chain Length
Authors: Piątek-Hnat Marta , Bomba Kuba , Kowalski-Stankiewicz Janusz P. , Pęksiński Jakub , Kozłowska Agnieszka , Sośnicki Jacek G. , Idzik Tomasz J. , Schmidt Beata , Kowalczyk Krzysztof , Walo Marta , Mikołajczak Grzegorz , Kochmańska Agnieszka
Published: April 2021

Poly(xylitol dicarboxylate-co-diol dicarboxylate) elastomers can by synthesized using wide variety of monomers with different chain lengths. Obtained materials are all biodegradable, thermally stable elastomers, but their specific properties like glass transition temperature, degradation susceptibility, and mechanical moduli can be tailored for a specific application. Therefore, we synthesized eight elastomers using a combination of two dicarboxylic acids, namely suberic and sebacic acid, and four different diols, namely ethanediol, 1,3-propanediol, 1,4-buanediol, and 1,5-pentanediol. Materials were further modified by e-beam treatment with a dose of 100 kGy. Materials both before and after radiation modification were tested using tensile tests, gel fraction determination, 1H NMR, and 13C NMR. Thermal properties were tested by Differential Scanning Calorimetry (DSC), Dynamic Thermomechanical Analysis (DMTA) and Thermogravimetric Analysis (TGA). Degradation susceptibility to both enzymatic and hydrolytic degradation was also determined.
Polymer-Derived Nitrogen-Doped Carbon Nanosheet Cluster and Its Application for Water Purification
Authors: Yu Xiaoyan , Zheng Ting , Pilla Srikanth
Published: April 2021

A series of nitrogen-doped carbons (NCs) were prepared by the pyrolysis (300–900 °C) of crystalline polyazomethine (PAM) synthesized via a facile condensation reaction in methanol solvent. The controlled solvent evaporation resulted in PAM crystals in the form of nanosheet clusters with a sheet thickness of ~50 nm. Such architecture was maintained after pyrolysis, obtaining porous CNs of high specific surface areas of up to 700 m2/g. The resulting NCs were used as absorbents to remove aromatic Rhodamine B from water. The NC that pyrolyzed at 750 °C exhibited the highest adsorption capacity (0.025 mg/mg), which is attributed to its high surface area and surface condition.
Extended Fuzzy Sets and Their Applications
Authors: Farhadinia Bahram , Chiclana Francisco
Published: April 2021

This contribution deals with introducing the innovative concept of extended fuzzy set (E-FS), in which the S-norm function of membership and non-membership grades is less than or equal to one. The proposed concept not only encompasses the concept of the fuzzy set (FS), but it also includes the concepts of the intuitionistic fuzzy set (IFS), the Pythagorean fuzzy set (PFS) and the p-rung orthopair fuzzy set (p-ROFS). In order to explore the features of the E-FS concept, set and algebraic operations on E-FSs, average and geometric operations of E-FSs are studied and an E-FS score function is defined. The superiority of the E-FS concept is further confirmed with a score-based decision making technique in which the concepts of FS, IFS, PFS and p-ROFS do not make sense.
Thanatochemical Study of Glycated Hemoglobin in Diabetic Status Assessment
Authors: Girlescu Nona , Stoica Bogdan , Timofte Andrei Daniel , Hunea Iuliana , Diac Madalina , Knieling Anton , Damian Simona Irina , Iov Tatiana , Iliescu Diana Bulgaru
Published: April 2021

Background and objectives. In forensic medicine, the postmortem determination of glycated hemoglobin (HbA1c) helps identify undiagnosed cases of diabetes or cases with uncontrolled glycemic status. In order to contribute to the solidification of thanatochemistry, both globally and especially nationally, we aimed to determine this biomarker postmortem, for the first time in our institution, in order to identify undiagnosed pre-mortem diabetics, as well as those with inadequate glycemic control. Materials and Methods. Our research consisted of analyzing a total number of 180 HbA1c values, 90 determinations from the peripheral blood and 90 from the central blood. The determination of HbA1c was performed by means of a fully automatic analyzer (HemoCue HbA1c 501), certified by the National Glycohemoglobin Standardization Program (NGSP)/Diabetes Control and Complications Trial (DCCT) and calibrated according to the standards developed by the International Federation of Clinical Chemistry (IFCC). According to ADA criteria, HbA1c values can provide us with the following information about the diagnosis of diabetes: normal 4.8–5.6%; prediabetes 5.7–6.4%; diabetes ≥ 6.5%. Results. A considerable number of cases with an altered glycemic status (cases that had HbA1c values equal to or greater than 5.7%) were identified—51% demonstrable by peripheral blood determinations and 41% by central blood determinations. Notably, 23 people with diabetes (25%) were identified by analyzing the peripheral blood; 18 other people with diabetes (20%) were identified by analyzing the central blood. Conclusions. Our study managed to confirm the antemortem diagnosis of DM using a simple point-of-care analyzer and applying standardized and certified criteria on HbA1c levels measured postmortem. We also identified a considerable number of cases with DM in patients with no antemortem history of glucose imbalance—at least 20% more cases. Although the two different sites used for blood collection showed a strong statistical correlation, it seems that the peripheral site could have a higher sensibility in detecting postmortem altered glycemic status.
Non-Respiratory Symptoms of Patients Infected with SARS-CoV-2 (Coronavirus Disease 2019): Lessons from Their Initial Presentation at the Hospital
Authors: Vasiliadis Angelo V. , Tsatlidou Maria , Metaxiotis Dimitrios , Psomiadis Charalampos , Beletsiotis Anastasios , Arvaniti Kostoula
Published: April 2021

Background and objectives: As the COVID-19 pandemic spreads, it is becoming increasingly evident that this coronavirus is not limited to the respiratory system and that the musculoskeletal system can also be affected. The purpose of the present study was to describe non-respiratory symptoms of laboratory-confirmed COVID-19 cases. Materials and Methods: All patients with SARS-CoV-2 admitted to our hospital, between 1 August and 30 September 2020, were included in this retrospective study. Data were extracted from medical records. Epidemiological, clinical, laboratory and radiological characteristics at the initial presentation at the hospital were collected and analyzed. Results: A total of 79 COVID-19 patients were enrolled. The mean age of the patients was 44.08 years (age range, 18–87 years) and 59.5% were male. The most common symptoms were fatigue in 60 (75.9%) patients, followed by fever (73.4%), myalgia (51.9%), cough (41.8%), anosmia (38%) and arthralgia (36.7%). The muscles of the upper back and the knee joint were the most painful anatomic region and joint, respectively. The laboratory findings on admission showed that D-dimer, CRP and procalcitonin levels were increased, without significant gender differences (p > 0.05). Chest imaging demonstrated pneumonia in 20 (25.3%) patients. Conclusions: Our results indicate that from the onset of the symptoms of COVID-19 patients, musculoskeletal symptoms, such as fatigue, myalgia and arthralgia, were present in three-quarters of all patients. These findings could help elaborate updated triage and admission protocols for suspect COVID-19 patients at the hospital and Emergency Department presentation.
Experience of Managing Suspected Placenta Accreta Spectrum with or without Internal Iliac Artery Balloon Occlusion in Two Lithuanian University Hospitals
Authors: Savukyne Egle , Liubiniene Laura , Strelcoviene Zita , Nadisauskiene Ruta Jolanta , Vaboliene Edita , Machtejeviene Egle , Kaupas Rytis , Lauzikiene Dalia
Published: April 2021

Background and objectives: Placenta previa and placenta accreta spectrum are considered major causes of massive postpartum hemorrhage. Objective: To determine whether the placement of an occlusion balloon catheter in the internal iliac artery could reduce bleeding and other related complications during cesarean delivery in patients with placenta previa and placenta accreta spectrum. Materials and Methods: A retrospective analysis was conducted at two tertiary obstetric units of Lithuania. From January 2016 to November 2019 patients with placenta previa and antenatally suspected invasive placenta were included in the intervention group and underwent cesarean delivery with endovascular procedure. From January 2014 to December 2015 patients with placenta previa and suspected placenta accreta spectrum were included in the non-intervention group. The primary outcomes were reduction in intraoperative blood loss and transfusion volumes in the intervention group. Secondary outcomes were the incidence of hysterectomy and maternal complications. Results: Nineteen patients underwent cesarean delivery with preoperative endovascular procedure, and 47 women underwent elective cesarean delivery. The median intraoperative blood loss (1000 (400–4500) mL vs. 1000 (400–5000) mL; p = 0.616) and the need for red blood cell transfusion during operation (26% vs. 23%; p = 0.517) did not differ significantly between the patients groups. Seven patients in the intervention group and two patients in the non-intervention group underwent perioperative hysterectomy (p = 0.002). None of the patients had complications related to the endovascular procedure. Conclusion: The use of intermittent balloon occlusion catheter in patients with placenta pathology is a safe method but does not significantly reduce intraoperative blood loss during cesarean delivery.
Positioning Accuracy Determination of the Servo Axes for Grinding Wavy-Tilt-Dam Seals Using a Four-Axis Grinder
Authors: Feng Guang , Ma Xiaobao
Published: April 2021

The wavy-tilt-dam (WTD) seal is considered to be one of the ideal sealing patterns used in nuclear reactor coolant pumps (RCPs). Grinding such seals with a four-axis grinder had been proposed and six grinding implementation strategies were described in our previous studies. However, another important issue is to determine the positioning accuracy of each servo axis so that the high-precision moving components can be selected properly. In the present paper, the positioning accuracy analysis is carried out to seek a balance between the manufacturing cost and the accuracy requirements. First, a geometric model is established for investigating the error sensitivity of each axis and setting reasonable accuracy allocation of the four axes. Subsequently, the combined influence of all four axes is assessed based on multi-body system (MBS) theory and homogeneous transformation matrix (HTM). According to the results calculated, positioning errors of the X-axis, Z-axis, B-axis, and C-axis within ±10 μm, ±0.1 μm, ±1 arcsec and ±60 arcsec are acceptable, respectively. Meanwhile, the form error calculated of the ground wavy face is no more than 109.74 nm. It is indicated that the accuracy level of the moving components is achievable by modern manufacturing techniques. The present paper is expected to serve as a theoretical basis for the design and development of the four-axis grinder.
Hurdle Effects of Ethanolic Plant Extracts with Antimicrobials Commonly Used in Food against Foodborne Pathogenic Escherichia coli
Authors: Kusalaruk Waraporn , Nakano Hiroyuki
Published: April 2021

Escherichia coli (E. coli) O157:H7 is a major foodborne pathogen that causes severe human infections. Plant extracts, glycine, and sodium acetate (NaOAc) exert antimicrobial effects that can be used to control pathogenic E. coli. However, their combinations have not been investigated. Thus, this study investigates the combination of ethanolic plant extracts with glycine and NaOAc against E. coli at various pH and temperature levels. Clove and rosemary extracts exhibited significant (p ≤ 0.05) antimicrobial activity against E. coli. At neutral pH, the combination of plant extracts with 1.0% glycine or 0.1% NaOAc reduced the minimum inhibitory concentration of clove from 0.4% to 0.2%; at pH 5.5, clove (0.1%) and rosemary (0.2%) extracts supplemented with NaOAc (0.1%) showed an additive effect. The population of E. coli O157:H7 in phosphate-buffered saline with 0.2% clove extract, 2% glycine, and 2% NaOAc showed a more than 5 log reduction after incubation at 15 °C for 96 h, while the combination of 0.1% clove extract with 2% NaOAc at pH 5.5 completely inhibited E. coli within 24 h at 35 °C. Thus, the combination of plant extracts with glycine and NaOAc could serve as a promising hurdle technology in controlling the growth of E. coli.
The Global Dimension of Tomato Yellow Leaf Curl Disease: Current Status and Breeding Perspectives
Authors: Yan Zhe , Wolters Anne-Marie A. , Navas-Castillo Jesús , Bai Yuling
Published: April 2021

Tomato yellow leaf curl disease (TYLCD) caused by tomato yellow leaf curl virus (TYLCV) and a group of related begomoviruses is an important disease which in recent years has caused serious economic problems in tomato (Solanum lycopersicum) production worldwide. Spreading of the vectors, whiteflies of the Bemisia tabaci complex, has been responsible for many TYLCD outbreaks. In this review, we summarize the current knowledge of TYLCV and TYLV-like begomoviruses and the driving forces of the increasing global significance through rapid evolution of begomovirus variants, mixed infection in the field, association with betasatellites and host range expansion. Breeding for host plant resistance is considered as one of the most promising and sustainable methods in controlling TYLCD. Resistance to TYLCD was found in several wild relatives of tomato from which six TYLCV resistance genes (Ty-1 to Ty-6) have been identified. Currently, Ty-1 and Ty-3 are the primary resistance genes widely used in tomato breeding programs. Ty-2 is also exploited commercially either alone or in combination with other Ty-genes (i.e., Ty-1, Ty-3 or ty-5). Additionally, screening of a large collection of wild tomato species has resulted in the identification of novel TYLCD resistance sources. In this review, we focus on genetic resources used to date in breeding for TYLCVD resistance. For future breeding strategies, we discuss several leads in order to make full use of the naturally occurring and engineered resistance to mount a broad-spectrum and sustainable begomovirus resistance.
Synthesis, Mesomorphic and Computational Characterizations of Nematogenic Schiff Base Derivatives in Pure and Mixed State
Authors: Al-Mutabagani Laila A. , Alshabanah Latifah A. , Ahmed Hoda A. , Alalawy Hafsa H. , Al alwani Mayada H.
Published: April 2021

Homolog series based on three aromatic rings bearing terminal alkoxy chain of various lengths named 4-(4-(alkoxy)phenylimino)methyl)phenyl nicotinate (An) were synthesized. The alkoxy-chain length changed between 6, 8 and 16 carbons. Mesomorphic and optical properties were carried out via differential scanning calorimetry (DSC) and polarized optical microscopy (POM). Elemental analyses, FT-IR and NMR spectroscopy were carried out to elucidate the molecular structures of the prepared derivatives. Mesomorphic results indicated that all the synthesized homologs (An) are monomorphic possessing the nematic (N) phase enantiotropically with wide thermal stability. Computational simulations were measured via density functional theory (DFT) theoretical calculation tool. The estimated thermal and geometrical parameters are in agreement with the experimental data. By discussing the estimated parameters, it was found that the molecular architecture, dipole moment and the polarizability of the investigated compounds are highly affected by the length of the attached terminal flexible chain and the location of the nitrogen atom in the other terminal aromatic ring. Binary phase diagrams of two corresponding homologs with different proportionating terminals were constructed, and their binary phase physical properties were discussed in terms of the temperature range and stability of the N phase.
Influence of Harvesting Time on the Chemical Composition of Wild Stinging Nettle (Urtica dioica L.)
Authors: Paulauskienė Aurelija , Tarasevičienė Živilė , Laukagalis Valdas
Published: April 2021

This research aimed to determine the effect of different harvesting times on the chemical composition of stinging nettle (Urtica dioica L.). The leaves of nettle were harvested at the same place once a month in the period of April–September 2019. The analysis focused on the contents of dry matter, soluble solids, ascorbic acid, titratable acidity, chlorophyll a and chlorophyll b, total carotenoids, total phenolic compounds, antioxidant activity, ash content, and macro- and microelements. The nettles harvested in April were characterized by the highest levels of soluble solids and some macro-and microelements (P, K, Fe, Zn). The plants harvested in May were distinguished for titratable acidity, chlorophyll a, chlorophyll b, and carotenoid contents. In this month, the plants were determined to have the highest antioxidant activity during the entire vegetation period. The plants collected in July contained the highest amount of Mn, but the antioxidant activity of these plants was the lowest during the vegetation period. In August, the plants had the highest levels of ascorbic acid, phenolic compounds, and ash, while the plants collected in September were characterized by having the highest amounts of Ca, Mg, and B as compared to those established in other months of vegetation.
Effect of Packing Material Composition on the Aerodynamic Processes in a Wavy Lamellar Plate-Type Biofilter
Authors: Baltrėnas Pranas , Januševičius Tomas , Kleiza Jonas
Published: April 2021

Reducing the pressure drop in biofilters is important for the reduction of the energy consumption of these devices. Usually, the pressure drop increases with time due to the biomass growth within the packing material. The aim of this study was to evaluate the aerodynamic processes in a laboratory-scale wavy lamellar (WL) plate-type biofilter equipped with a capillary system for humidifying the packing material. The packing material of a designed biofilter consisted of wavy polymer plates (WPP) vertically arranged next to each other. The pattern of arrangement of the plates allowed sufficiently large spaces, and therefore, the use of such structure had an impact on a decrease in the pressure drop of the biofilter. WPP were coated with three different kinds of materials, namely (I) wood fiber (WF), (II) non-woven caulking material (NWCM) and WF, and (III) linen material (LM) and WF. The results showed that the composition of the packing material influenced pressure drop of the biofilter. The packing material, which consisted of WPP covered with WF, had the lowest pressure drop compared with the other two packing material compositions. In this study, the experimental results were also compared with the results of the performed mathematical modeling of airflow movement.
Discriminative Learning Approach Based on Flexible Mixture Model for Medical Data Categorization and Recognition
Authors: Alharithi Fahd , Almulihi Ahmed , Bourouis Sami , Alroobaea Roobaea , Bouguila Nizar
Published: April 2021

In this paper, we propose a novel hybrid discriminative learning approach based on shifted-scaled Dirichlet mixture model (SSDMM) and Support Vector Machines (SVMs) to address some challenging problems of medical data categorization and recognition. The main goal is to capture accurately the intrinsic nature of biomedical images by considering the desirable properties of both generative and discriminative models. To achieve this objective, we propose to derive new data-based SVM kernels generated from the developed mixture model SSDMM. The proposed approach includes the following steps: the extraction of robust local descriptors, the learning of the developed mixture model via the expectation–maximization (EM) algorithm, and finally the building of three SVM kernels for data categorization and classification. The potential of the implemented framework is illustrated through two challenging problems that concern the categorization of retinal images into normal or diabetic cases and the recognition of lung diseases in chest X-rays (CXR) images. The obtained results demonstrate the merits of our hybrid approach as compared to other methods.