bluuebunny/crossref_metadata_2025 huggingface dataset:
El estatuto de los diputados del Congreso. Viejos y nuevos problemas
Authors: Cámara Villar Gregorio
Published: November 2022

Se abordan en este estudio cuestiones centrales del estatuto de los Diputados, tanto desde una perspectiva subjetiva como objetiva, a partir de la naturaleza y configuración constitucional y reglamentaria del mandato parlamentario, con la mirada puesta en una posible reforma del Reglamento del Congreso de los Diputados, necesaria cuando se han cumplido cuarenta años de su vigencia. A estos efectos se revisitan viejos problemas y se valoran otros nuevos a la luz de la evolución de nuestro sistema político, de la doctrina académica y la jurisprudencia constitucional. En concreto se realizan precisiones y algunas propuestas sobre derechos, deberes y régimen de incompatibilidades de los Diputados;  se analizan y valoran con detalle las prerrogativas parlamentarias, acerca de las cuales se plantean serios interrogantes y, sobre ellos, determinadas propuestas: inviolabilidad, inmunidad y fuero especial; se hacen observaciones y, del mismo modo, propuestas sobre el tan problemático requisito de prestar promesa o juramento para la adquisición plena de la condición de diputado; se aborda la configuración reglamentaria de los distintos supuestos de suspensión; se analiza la posibilidad de regular la sustitución de un diputado en determinados supuestos de suspensión y en otras situaciones, cuestión que aunque no se contemple en nuestro Derecho parlamentario, pero sí en otros países, sigue siendo objeto de debate doctrinal.

Finaliza el estudio con una reflexión sobre la situación del diputado ante su grupo parlamentario, concluyendo con la necesidad de una reforma reglamentaria que permita, además de contemplar posibles modificaciones o regulaciones sobre las cuestiones antes referidas...
El estatuto del diputado: nuevos y viejos problemas
Authors: Peñaranda Ramos José Luis
Published: November 2022

El autor comenta la exposición del Profesor Cámara Villar sobre el estatuto del diputado en las Jornadas sobre el Aniversario del Reglamento del Congreso de los Diputados. El Profesor Cámara en su exposición analiza no solo los aspectos del Título I del Reglamento, sino otros de gran importancia práctica como son la naturaleza y alcance del mandato parlamentario centrada, sobre todo, en la “reivindicación equilibrada” entre las competencias del parlamentario individual y la disciplina del grupo político al que pertenece. 

El artículo examina además otros aspectos jurídicos novedosos como la votación telemática, profusamente utilizada durante la pandemia del COVID, el régimen de incompatibilidades tanto públicas como privadas y la necesidad de su reforma en profundidad, así como el aforamiento del parlamentario, su inviolabilidad, los criterios para el otorgamiento o denegación del suplicatorio, todo ello, bajo los criterios interpretativos de la jurisprudencia del Tribunal Constitucional y la doctrina más reciente.
HUBUNGAN DEPRESI DENGAN KEJADIAN HIPERTENSI PADA PASIEN LANJUT USIA
Authors: ENDE ARDIANUS MELKI
Published: November 2022

Latar Belakang: Depresi merupakan masalah psikologis yang banyak terjadi pada lanjut usia yang ditandai dengan perasaan sedih mendalam yang berdampak pada gangguan interaksi sosial.  Prevalensi kejadian Depresi dan Hipertensi cukup tinggi. Menurut World Health Organization prevalensi global gangguan depresi pada lansia didapatkan sebanyak 61,6 % (WHO, 2017). Menurut WHO (World Health Organization) Dan ISH (The International Society of Hypertension) Tahun 2003), terdapat 600 juta penderita hipertensi di seluruh dunia, dan 3 juta di antaranya meninggal setiap tahunnya.

Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui hubungan depresi dengan kejadian hipertensi pada lanjut usia.

Metode Penelitan: Penelitian ini menggunakan studi Literatur. Search engina/ database yang digunakan yaitu google scholar dan science direct dalam periode 5 tahun terakhir dalam bahasa Indonesia dan bahasa Inggris dengan kata kunci dalam pencarian yaitu ”Depresi dan Hipertensi pada Lanjut Usia” yang sesuai dengan kriteria inklusi dan eksklusi.  

Hasil Penelitan: Dari 10 artikel yang telah direview terdapat 8 artikel yang  menyatakan terdapat hubungan depresi dengan kejadian hipertensi pada lansia yaitu jurnal (1-8). Yang menyatakan terdapat hubungan depresi dengan kejadian hipertensi pada lansia yaitu ( p=0,000 < 0,05). Sementara itu 2 jurnal menyatakan tidak ada hubungan depresi dengan kejadian hipertensi pada lansia (P=0,583), (P=0,583).

Kesimpulan : Dapat disimpulkan bahwa terdapat hubungan depresi dengan kejadian hipertensi pada lanjut usia
Transcatheter Repair of Congenital Heart Defects in the Young
Authors: El-Saiedi Sonia A. , Attia Wael A. , Sobhy Rodina
Published: November 2022

In recent decades, tremendous medical advances have been made. Therapeutic cardiac catheterisation for repair of congenital heart defects has become the standard mode of therapy. Catheter techniques have progressed. They now provide temporary palliation, prepare the patient for surgical reconstruction, or offer a definitive repair. The main advantages of non-surgical procedures are avoidance of thoracotomy and cardiopulmonary bypass, together with a shorter hospitalisation period and speedier convalescence.

Paediatric interventions include: transcatheter device closure of congenital cardiac defects, balloon angioplasty and valvuloplasty, atrial septostomy, patent ductus arteriosus stenting in the neonatal period, vessel embolisation, and many others. Topping those interventions is the introduction of transcatheter valve replacement. The aim of this article is to review these interventions and present them in a simplified, vibrant, and up-to-date fashion.

In conclusion, paediatric cardiac interventions have established their reliability and ever-expanding scope in the setting of congenital heart disease management. Nevertheless, success is dependent on selecting the proper procedure for each condition, which may also vary with each patient. Thus, it is highly dependent on the experience and expertise of the operator. With the current rate of technological innovation, more and more surgical procedures will eventually be replaced by catheter-based interventions with a great degree of safety and efficacy.
Interim Results of the Basket of Real-World Randomised Clinical PRISM Trials for M’Sure-S, a Next-Generation Sirolimus-Eluting Stent, Versus Eliminator, an Everolimus-Eluting Stent
Authors: Silvestri Marc , Cholenahally Nanjappa Manjunath , Gowda Raghu Rame , Jambunathan Rajagopal
Published: November 2022

Objective: This study compared sirolimus-eluting stents (SES) with everolimus-eluting stents (EES) in coronary artery disease patients.

Methods: A total of 1,174 patients were enrolled in the study; 290 patients (25.28%) were treated with EES and 884 patients (74.72%) were treated with SES. The trial (PRISM) was a randomised (in a 3:1 ratio), multicentre, single-blind, all-comers, single-arm, non-inferiority trial comparing SES and EES-implanted patients with coronary artery disease. The primary endpoint was a composite of safety parameters (including major adverse cardiac events [MACE], cardiac death, and myocardial infarction) and efficacy (parameters concerned to quantitative coronary angiogram). An intention-to-treat analysis was performed at 9 and 18-month follow-ups.

Results: The baseline characteristics were similar for both EES and SES groups. At the 9-month follow-up, MACE occurred in 5.86% and 2.43% of patients in the EES and SES groups, respectively. At the 18-month follow-up, this differential remained almost the same (i.e., 5.17 % of patients treated with the EES versus 2.14% treated with the SES). The rate of definite stent thrombosis at 9-month follow-up was lower in the SES group (11 patients [1.24%]) compared to the EES group (9 patients [3.10%]). At 18-month follow-up, the rate was 2.14% (19 patients) in the SES group and 4.13% (12 patients) in the EES group. When censoring the patients at the time of stent thrombosis, no significant differences between the two stent groups were found.

Conclusion: In this real-world trial, at 9 and 18-month follow-ups, SES (M’Sure-S) exhibited a better safety and efficacy profile when compared to EES in terms of MACE rates and definite stent thrombosis. However, the difference was not statistically significant and SES was found to be non-inferior to EES.
Current Status of Fully Automated Software with Three-Dimensional Echocardiography for The Quantification of Left Ventricular Function
Authors: Yang Li-Tan , Takeuchi Masaaki
Published: November 2022

Echocardiography has an important role in the diagnosis, treatment, and management of patients who require transcatheter valvular interventions. Left ventricular ejection fraction (LVEF) is a very popular parameter for the assessment of LV function. Although several cut-off values of LVEF have been used for decision making in patients with valvular heart disease, less attention has been paid to its accuracy and reliability. Observer variability is a significant concern, and >10% differences in LVEF measurements between two sonographers could occur in the same two-dimensional echocardiography datasets. The adoption of fully automated LV quantification software with three-dimensional echocardiography (3DE) might be one potential solution to eliminate this problem. We will review the current status of fully automated software with 3DE for the assessment of LV volumes and LVEF.
Percutaneous Coronary Intervention for Chronic Total Occlusion, A Review of Indications, Techniques, and Complications
Authors: Ferrer-Gracia Maria-Cruz
Published: November 2022

Percutaneous coronary intervention for chronic total occlusion (CTO) remains a challenging prospect for many interventional cardiologists. The treatment of these lesions is heterogeneous, as is the success rate. The aim of this review is to learn about how to approach these patients and lesions and discover the latest tendencies and research in interventional approaches in this field, as well as how to perform a useful pre-procedural approach, dual injection, lesion crossing, and modification to success. Finally, complications specific to CTO percutaneous intervention should be taken into account. Current guidelines, recommendations, and references to other significant articles which detail different aspects of management in patients with these complex lesions could be a useful guide for people beginning in this area. Algorithms of treatment, step approach, and proctoring are the current tendencies for CTO.
Kajian Media Interaksi Anak Usia Dini Semasa Pembelajaran Jarak Jauh (Studi Kasus TK Islam Al-Azhar 20 Cibubur dan Sekolah Murid Merdeka)
Authors: Ardhiana Rizki Riandini , Nadiyah Tsamarah , Ratri Dianing , Sihombing Riama Maslan
Published: November 2022

AbstrakPendidikan merupakan investasi jangka panjang yang perlu diperhatikan sejak dini. Dukungan lembaga pendidikan prasekolah dianggap penting guna mendampingi orang tua memberikan tahapan stimulus yang sesuai hingga dapat memaksimalkan potensi anak. Dikarenakan kondisi COVID-19, pertemuan tatap muka berganti menjadi pembelajaran jarak jauh (PJJ), begitu pula pada level pendidikan prasekolah. Aspek motorik, kognitif, sosial, serta emosional anak sedang berkembang pesat di usia 2-6 tahun. Dibutuhkan interaksi intensif untuk memberikan stimuli, ruang gerak, ruang bicara dan berekspresi, serta pengalaman sosial. Pada penelitian ini diteliti adaptasi lembaga pendidikan prasekolah untuk menghadirkan ragam stimulus ini di rumah, dengan memaksimalkan penggunaan media digital dan analog. Hasil penelitian menyatakan bahwa jenis aktivitas yang paling diminati oleh anak yaitu eksperimen sains (20%), story telling (20%), menggambar (16%), dan pertemuan kelas daring melalui Zoom (13%). Aktivitas yang diminati oleh anak usia TK A dan TK B berbeda. Pada usia lebih besar, anak tertarik pada tantangan, kompetisi, dan eksplorasi. Sistem blended learning diterapkan sebagai penyeimbang media belajar analog dan digital, serta pembelajaran konvensional dan aktivitas mandiri.   Kata kunci: Sistem Pembelajaran Campuran, Media Edukasi Digital, Lembaga Prasekolah Daring AbstractEducation is a long-term investment that needs our attention since the early stage of our children. Support from preschool institutions is considered important for accompanying parents to provide appropriate stimulus stages to obtain maximizing the potential of the child. Due to the condition of COVID-19, all classes change to online learning, likewise at preschool education level. Motor, cognitive, social, and emotional aspects is growing rapidly at the age of 2-6 years. Intensive interaction is required to provide stimuli, space for movement, space for speech and expression, as well as social experience. This research examines the adaptation of preschool education to present these kinds of stimuli at home, with maximize the use of digital and analogue media. The results showed that the types of activities most interested for children were science experiments (20%), story telling (20%), drawing (16%), and online class meetings through Zoom (13%). Children from kindergarten A and kindergarten B have different readability. At an older age, children are attracted to challenges, competition, and exploration. The blended learning system is applied as a counterweight to analogue and digital learning media, as well as conventional learning and independent activities. Keywords: Blended-Learning System, Digital Media Education, Online Preschool
Pengaruh Nilai Islam pada Visual Pakaian Pengantin Adat Minangkabau Koto Gadang
Authors: Akbar Taufik , Imelda Desra , Prameswari Nadia Sigi , Putri Selfi Mahat
Published: November 2022

Abstrak Pakaian pengantin tradisional Koto Gadang merupakan salah satu produk seni budaya Minangkabau yang identik dengan nilai Islam. Walaupun bukan sebagai tempat masuknya Islam di Minangkabau dan Sumatera Barat tetapi masyarakat Koto Gadang mampu mencerminkan nilai Islam yang kuat pada visual pakaian pengantin yang khas. Penelitian ini adalah sebuah pengamatan visual tentang nilai-nilai Islam yang diwakili melalui pakaian pengantin Koto Gadang. Pengamatan dilakukan dengan pendekatan etnografis Spradley melalui analisis elemen dan komponen visual pakaian pengantin Koto Gadang serta didukung oleh teori semiotika dyadic Ferdinand De Saussure. Hasil penelitian menunjukan pengaruh nilai-nilai Islam pada busana mempelai wanita terdiri dari telekung, baju kurung, dan sarung kodek. Pada pakaian mempelai pria pengaruh Islam terlihat jelas pada atribut penutup kepala yang disebut deta ameh gadang dan kain penutup celana yang disebut sesamping. Penelitian ini dapat menambah studi tentang pengaruh sosio-kultural terhadap karya seni, khususnya di Sumatera Barat. Kata Kunci: budaya Minangkabau, nilai Islam, pakaian pengantin, Koto Gadang, etnografi AbstractThe Koto Gadang traditional wedding dress is one of the Minangkabau’s cultural arts product that are identical to Islamic values. Although not as a place for the entry of Islam in Minangkabau and West Sumatra, the Koto Gadang community is able to reflect strong Islamic values in the visuals of a distinctive wedding dress. This research is a visual observation about the Islamic values represented through the Koto Gadang wedding dress. Observations performed with an ethnographic approach through a process of Spradley’s visual components analyzing in the Koto Gadang wedding dress and also supported by the dyadic semiotics theory of Ferdinand De Saussure.The result of the analysis show that there are influences of Islamic values in trousseau consist of telekung, baju kurung, and kodek sarong. In the groom's clothes, the influence of Islamic values clearly visible in turban called deta ameh gadang and the cloth covering pants called sesamping. This research is expected to contribute to the study of socio-cultural influences in artworks, particularly in West Sumatra. Keywords: ethnographic, Islamic values, Koto Gadang, Minangkabau culture, wedding dress
Penanda Budaya Visual pada Desain Kemasan Jamu Tradisional Banyuwangi Jawa Timur
Authors: Sutarya Abdul Majid , Pujiyanto Pujiyanto
Published: November 2022

AbstrakJamu tradisional merupakan warisan budaya Indonesia diantara keragaman, hasil dari budaya yang memiliki keragaman jamu tradisional. Salah satunya daerah Banyuwangi yang merupakan penghasil jamu tradisional yang terdapat di wilayah Jawa Timur. Penelitian ini menggunakan deskriptif kualitatif dengan pendekatan semiotika Roland Barthes yang menganalisis elemen visual pada desain kemasan jamu Banyuwangi. Hasil dari penelitian ini adalah Konotasi, Denotasi dan Mitos dalam visual sangat tampak budaya yang terdapat pada desain kemasan jamu di Banyuwangi sehingga prinsip desain terbantuk seirama dan memiliki kesatuan. Hal ini membuat desain kemasan jamu melekat pada masyarakat Banyuwangi sehinga produsen mempertimbangkan elemen visual untuk memikat masyarakat dalam hal ini sebuah kebutuhan. Segmentasi yang ditujukan oleh produsen jamu dapat memikat dan membuat jamu tradisional Banyuwangi mempunyai jati diri identitas dalam desain Kemasan Jamu.Kata Kunci: Banyuwangi, desain kemasan, elemen visual, jamu tradisional, semiotika AbstractTraditional herbal medicine is Indonesia's cultural heritage among diversity, the result of a culture that has a diversity of traditional herbs. One of them is banyuwangi area which is a producer of traditional herbal medicine found in the East Java region. This research uses qualitative descriptive with Roland Barthes’s semiotics approach that analyze visual elements in the packaging design of Banyuwangi herbal medicine. The result of this study is Connotation, Denotation and Myth in visuals are very visible culture contained in the design of herbal medicine packaging in Banyuwangi so that the design principles are helped in harmony and have unity. This makes the design of herbal medicine packaging attached to the banyuwangi community so that manufacturers consider visual elements to lure the community in this case a need. Segmentation aimed at herbal medicine manufacturers can attract and make traditional Banyuwangi herbal medicine has an identity identity in the design of Jamu Packaging.Keywords: Banyuwangi, packaging design, semiotic, tradisional herbal medicine, visual element
The Use Of Talking Stick Method On The Theme Of Animal And Human Movement Organs In Grade 5 To Improve Student's Speaking Skills
Authors: Rozianzah Afandi Nur , Siswanto Bambang Edi
Published: November 2022

ABSTRACT

       This research aims to improve skills speak through the use of a method of talking stick class students V SD Islam Al-Washoya Kurto Rejo Ngoro Jombang. Skill talk observed in this research include linguistic nonlinguistic. aspects and on the aspect of pronunciation, linguistic consisting of intonation and, choice of words while on the aspect of nonlinguistic consisting of the smooth, loudness voice and mastery of the topic.

This kind of research is to research a class action ( PTK ). The subject of this research is the student Class v SD Islam Al-Washoya Kurto Rejo Ngoro Jombang 15. interviewed students A design study that used is a model Kemmis and MC. Which includes the planning stage, Taggart the implementation of the act of, , observation and the reflections. An instrument of data used is the test to show off, work sheets of observation teachers and students as well as. Documentation Data collection analysis techniques used are descriptive. Quantitative data analysis.

The research indicated that the use of the media talking stick can increase speaking skills students primary school class V Islam Al-Washoya Kurto Rejo Ngoro Jombang in terms of the process and the results of. An increase in the process in terms of rata-rata observations the activity of students who were not even in good category in the cycle I with the percentage 86,66 % increase in the cycle will be 93,33 % and included in the category of very good.

Be seen in terms of the results of, evidenced by the value of average talk students skills on initial conditions 63,38 increased to 74,88 on cycle I and increased to 78,44 on II. The percentage KKM also increased from 60 % in pre the act of increased to 80 % in the I and 90 % in II cycle.

 

Keywords :  Skill speak , a method of talking stick
The Effect Of Probing-Prompting Learning Model On Students’ Interest And Learning Outcomes Of Mathematics In Grade IV SDN Tejo 1 Mojoagung Jombang
Authors: Anhar Santika Putri Dwi , Nuruddin Muhammad
Published: November 2022

This study aims (1) to determine student learning outcomes on mathematics subjects with the influence of the probing-prompting learning model for fourth grade students. (2) to determine student responses to interest and student learning outcomes in mathematics with the influence of class IV probing-prompting learning model. (3) to explain whether or not there is an effect of the probing-prompting learning model on the interest and learning outcomes of fourth grade mathematics students at SDN Tejo 1 Mojoagung. This research was conducted at SDN Tejo 1 Mojoagung Jombang in April - May, 2021/2022 academic year. The research approach used in this research is quantitative, the type of research is descriptive research. The number of samples in this study amounted to 24 students in class IVB SDN Tejo 1 Mojoagung. In calculating the data analysis, the researcher used descriptive statistics and sample paired statistics. Data collection techniques in the form of tests and questionnaires as well as documentation. The results of data calculations using sample paired statistics state the results are sig2-talled) or the significance shows the results of 0.00 which means <0.05. So it can be concluded that there is a significant influence on the learning process using the probing-prompting learning model on the interest and learning outcomes of fourth grade students in mathematics at SDN Tejo 1. Based on the results of the conclusions above, suggestions are made for teachers to use to apply learning with the Probing-prompting learning model in mathematics lessons on flat shapes in grade IV. Because the results of this study indicate the probing-prompting learning model has an effect on students' interests and learning outcomes.
The Development Of Animal Monopoly Media On Themes “Objects, Animals And Plants Around Me” In Grade 1 At Mi Al-Ma'arif Sukomulyo
Authors: Desydera Farah Agista , Alfiansyah Iqnatia , Umam Nanang Khoirul
Published: November 2022

This development research aims to know the effectiveness of animal monopoly learning media (MONOWAN) theme 7 sub theme 2 about animals around me students in 1st Grade of MI Al-Ma'arif Sukomulyo. The process of developing learning media using a modified and simplified 4-D model is defined, design, develop and without disseminate. The result of the development of learning media in the form of Animal Monopoly. The data source in this development study is class I students MI Al-Ma'arif Sukomulyo who numbered 33 students. Data collection used is validation of learning media validation of learning materials, questionnaire response of students, and test of learning results. With data analysis, the analysis of the validity of learning media, the analysis of the practicality of learning media, and the effectiveness of learning media.

Based on the results of descriptive analysis of validation data and trial data obtained that the development of Animal Monopoly learning media for materials on the theme of 7 sub themes 2 learning 1 grade I MI Al-Ma'arif Sukomulyo meets the criteria well, which is as follows : a) The results of validation of learning media performed by validators obtain 81,66% percentage that are categorized in valid and can be used during the learning process , b) Practically categorized from the results of analysis in the practicality of learning media by validators shows that the media can be used with little revision or without revision, c) Categorized effectively from the results of the analysis of learning completeness, the results of the percentage of classical learning completeness of 96,969%, then it can be said that the learning completeness of the learners has been achieved, and the percentage of the results of the student's response to the learning media of Animal Monopoly by 100% can be said to be positive.

Keywords: MonopolyAnimals; Learning Media; Second Grade Students; Developing Learning
Natural Science Contextual Learning Ecosystem Materials For Class V Elementary School Students
Authors: Dwinata Anggara , Yunita Rahma Pratiwi Emy , Asmarani Ratih
Published: November 2022

This study aims to determine the effectiveness of the contextual learning model on learning outcomes of Natural Sciences material for the fifth grade elementary school students. The method used in this study is a quantitative method with the research design used is Pretest Posttest Control Group Design. The sample used in this study found 23 students consisting of 11 female students and 12 male students. Data analysis techniques used in this study include normality test, homogeneity test, and t-test. The results showed that there was a significant effect on the effectiveness of the contextual learning model in learning natural sciences on ecosystem materials. This can be shown by the value of the hypothesis test with a t-test of 5.501 > 2.015 (df; 44). On the other hand, which shows the significance value is the result obtained by 0.003 < 0.05 (5%). So it can be concluded that there are significant differences in the results of the post-test of students in the control and experimental groups.
APPLICATION OF THE SNOWBALL THROWING TYPE OF COOPERATIVE LEARNING MODEL ON WATER POLLUTION MATERIAL AT AL-FURQAN JUNIOR HIGH SCHOOL
Authors: Hidayatullah  , Oktafi Arinna Manasikkana
Published: November 2022

In learning process, teachers was expect to be able to make students to be active, be able to solve problems, and learning to respect the opinions of other friends. One of the solutions to solve this problem is using the Snowball Throwing learning model. This study aims to determine the implementation of learning using the ‘snowball throwing’ model on water pollution material, the implementation of learning can be seen from student responses and student learning outcomes after implementing the snowball throwing learning model. The design of this study was a quasi-experimental using a one-group pretest-posttest research design. The population of this study was VII D class that consist of 23 students at SMP Al-Furqan Diwek Jombang. The sample used in this study was VII D class, with totaling 23 students. The data collection technique used in this study there are three methods, namely observation, test method, and questionnaire method. Based on the observations, the results of the implementation of learning using the Snowball Throwing model on teacher’s activities shows an average of 89.95%, and student’s activities was obtained an average of 91.9%. From these two averages, it can be seen that the implementation of learning went well. Student learning outcomes on cognitive tests have an average of 85% with complete criteria. While the student response has an average of 90.8% a positive response from students.
KEKHASAN MOTIF TENUN KAMBE-KAMBERA DALAM TENUN TRADISIONAL MUNA
Authors: Sari Fitria Cahya , Sailan Zalili , Sahlan Sahlan
Published: November 2022

Penelitian ini bertujuan untuk (1) Menganalisis Dan Mendeskripsikan Bentuk-bentuk Motif tenun Kambe-Kambera Dalam Tenun Tradisional Muna, (2) Menganalisis dan Mendeskripsikan makna simbolik motif tenun Kambe-Kambera dalam tenun tradisional Muna, (3) Menganalisis dan Mendeskripsikan Nilai-Nilai yang Terkandungdalam Motif tenun Kambe-Kambera dalam Tenun Tradisional Muna. Penelitian ini menggunakan metode kualitatif. Pengumpulan data dengan metode observasi, wawancara dan dokumentasi. Informan penelitian berjumlah 5 orang. Teknik analisis data menggunakan semiotic Charles Sanders Pierce. Berdasarkan hasil penelitian dapat disimpulkan bahwa kain tenun kambe-kambera pada masyarakat Muna terinspirasi dari bentuk fauna dengan menggunakan motif dasaryaitu motif alami dan motif dekoratif. Bentuk-Bentuk Motif tenun Kambe-Kambera dalam tenun tradisional Muna sarung bhotu,Samasili, Mango-manggopa, Lejha, Bhia-bhia. Makna Simbolik Motif Tenun Kambe-kambera dalam tenun tradisional Muna Sarung bhotu : (symbol 8 berpasangan) Sarung samasili : (symbol 8 berpasangan ), sarung Manggo-manggopa (symbol 6 berpasangan,Sarung lejha : (symbolnya 4 berpasangan), Sarung bhia-bhia : ( simbolnya 6 berpasangan ). Nilai-nilai pada kain tenun kambe-kambera , Nilai religious, Nilai Pendidikan antara lain tanggung jawab, kepedulian social dan kerja keras. Nilai budaya, Nilai Ekonomi, Nilai Estetika.
The application of classic laryngeal mask airway combined with a self-created adaptor in interventional bronchoscopy for pediatric patients: A case series and literature review
Authors: Song Xuesong , Yan Na , Zhao Zhuang , Li Zhiwen
Published: November 2022

Purpose

To verify the feasibility of classic laryngeal mask airways (cLMA) combined with self-created adaptors in the interventional bronchoscopy of subglottic lesions for pediatric patients.

Methods

Three children who were diagnosed with upper airway lesions, subglottic stenosis (scar hyperplasia), and congenital laryngomalacia were respectively subjected to fiberoptic bronchoscopy (FOB) and therapeutic interventions. A classic laryngeal mask airway combined with a self-created adaptor was applied during the FOB procedures.

Results

In our cases, the vocal cord, glottis, trachea, and lesions were easily exposed, which provided an effective ventilation or oxygenation for the patients. Furthermore, both surgeons and patients were comfortable with the technique. Vital signs were stable during the procedures, including blood pressure, heart rate, and the saturation of pulse oximetry.

Conclusion

By retaining spontaneous breathing, the application of a classic laryngeal mask airway combined with a self-created adaptor is a feasible alternative method of airway management during FOB interventional procedures for pediatric patients.
MCI-frcnn: A deep learning method for topological micro-domain boundary detection
Authors: Tian Simon Zhongyuan , Yin Pengfei , Jing Kai , Yang Yang , Xu Yewen , Huang Guangyu , Ning Duo , Fullwood Melissa J. , Zheng Meizhen
Published: November 2022

Chromatin structural domains, or topologically associated domains (TADs), are a general organizing principle in chromatin biology. RNA polymerase II (RNAPII) mediates multiple chromatin interactive loops, tethering together as RNAPII-associated chromatin interaction domains (RAIDs) to offer a framework for gene regulation. RAID and TAD alterations have been found to be associated with diseases. They can be further dissected as micro-domains (micro-TADs and micro-RAIDs) by clustering single-molecule chromatin-interactive complexes from next-generation three-dimensional (3D) genome techniques, such as ChIA-Drop. Currently, there are few tools available for micro-domain boundary identification. In this work, we developed the MCI-frcnn deep learning method to train a Faster Region-based Convolutional Neural Network (Faster R-CNN) for micro-domain boundary detection. At the training phase in MCI-frcnn, 50 images of RAIDs from Drosophila RNAPII ChIA-Drop data, containing 261 micro-RAIDs with ground truth boundaries, were trained for 7 days. Using this well-trained MCI-frcnn, we detected micro-RAID boundaries for the input new images, with a fast speed (5.26 fps), high recognition accuracy (AUROC = 0.85, mAP = 0.69), and high boundary region quantification (genomic IoU = 76%). We further applied MCI-frcnn to detect human micro-TADs boundaries using human GM12878 SPRITE data and obtained a high region quantification score (mean gIoU = 85%). In all, the MCI-frcnn deep learning method which we developed in this work is a general tool for micro-domain boundary detection.
PfATP4 inhibitors in the Medicines for Malaria Venture Malaria Box and Pathogen Box block the schizont-to-ring transition by inhibiting egress rather than invasion
Authors: Barnes Claudia B. G. , Dans Madeline G. , Jonsdottir Thorey K. , Crabb Brendan S. , Gilson Paul R.
Published: November 2022

The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na+ homeostasis in malaria parasites and has been implicated in the mechanism of action of many structurally diverse antimalarial agents, including >7% of the antimalarial compounds in the Medicines for Malaria Venture’s ‘Malaria Box’ and ‘Pathogen Box’. Recent screens of the ‘Malaria Box’ and ‘Pathogen Box’ revealed that many PfATP4 inhibitors prevent parasites from exiting their host red blood cell (egress) or entering new host cells (invasion), suggesting that these compounds may have additional molecular targets involved in egress or invasion. Here, we demonstrate that five PfATP4 inhibitors reduce egress but not invasion. These compounds appear to inhibit egress by blocking the activation of protein kinase G, an enzyme that, once stimulated, rapidly activates parasite egress. We establish a direct link between egress and PfATP4 function by showing that the inhibition of egress is attenuated in a Na+-depleted environment and in parasites with a mutation in pfatp4. Finally, we show that PfATP4 inhibitors induce host cell lysis when administered prior to the completion of parasite replication. Since host cell lysis mimics egress but is not followed by invasion, this phenomenon likely explains why several PfATP4 inhibitors were previously classified as invasion inhibitors. Collectively, our results confirm that PfATP4-mediated Na+ efflux is critical to the regulation of parasite egress.
Climate services for the railway sector: A synthesis of adaptation information needs in Europe
Authors: Attoh Emmanuel M. N. A. N. , Goosen Hasse , van Selm Merlijn , Boon Eva , Ludwig Fulco
Published: November 2022

Given that climate variability and change present unprecedented challenges to the rail sector, efforts to produce relevant climate data/information for climate risk management and adaptive decision making in the rail sector are gaining traction. However, inadequate understanding of climate change impact and information needs raises several concerns for the sector. This paper addressed the question: What climate risk information services are needed to support the adaptation needs of the rail sector? Data from interviews, literature reviews, and workshops were used. The results show that changes in precipitation, temperature, sea-level rise, and thunderstorms are the top drivers of climate risk in the sector. Additionally, the need for tailor-made climate information to manage these changes is in high demand. Although insufficient, rail organizations use special protocols to manage climate risk. Understudied countries have operational and design standards formulated in metrics and codes related to specific critical weather conditions as part of their Natural Hazard Management process. However, desirable adjustments in the standards are currently based on past events rather than future climate conditions. Future climate change information is relevant for medium- to longer-term decisions, strategy, and policymaking. For operational and design standards, weather and climate information provided by national weather service agencies are used but they also refer to the European standards and databases. National level data/information is preferred for developing thresholds for standards yet pan-European level information is also relevant in filling in missing data gaps. Therefore, rail organizations operate on flexibility and a “use of best available data” policy. Understanding how climate information is used to support decision-making in the rail sector is by no means an easy task given the variety of decisions to be taken at different spatial and temporal scales. However, stakeholder engagement proved to be an important step to better inform tailor-made information that is user relevant.
Community livelihoods and forest dependency: Tourism contribution in Nyungwe National Park, Rwanda
Authors: Akayezu Providence , Ndagijimana Isidore , Dushimumukiza Marie Claire , Bernhard Katie P. , Groen Thomas A.
Published: November 2022

Introduction

Communities living adjacent to protected areas in Africa are characterized by high poverty rates and their well-being often depends on park resources. This often results in forest degradation and decline in wildlife populations, for example due to illegal hunting for bush meat. To counter this challenge in Rwanda, a tourism revenue sharing program was initiated in 2005, with 5% (doubled to 10% in 2017) of the park gate fees invested in community development projects. We evaluated the effectiveness of this tourism revenue sharing from 2005 to 2017, targeting communities adjacent to Nyungwe National Park located in south-western Rwanda.

Methods

We used questionnaires addressed to members of community associations and local government in 24 sectors around Nyungwe National Park. Additionally, data on illegal resource use and socio-economic status of the surrounding communities were obtained to quantitatively triangulate and draw insights from communities’perceptions. Using spatial analyses and spatial regression, we mapped trends in illegal activities relative to socio-economic characteristics.

Results and discussion

Both the qualitative and quantitative results indicate that the tourism revenue sharing program has not fully succeeded in improving community well-being around Nyungwe National Park. The tourism revenue sharing can consider targeting areas that demonstrate more need and reassessing prioritization of interventions supported by the program to achieve both poverty reduction around Nyungwe National Park and improved conservation outcomes in this protected area.
Risk factors, clinical features, and outcomes of premature acute myocardial infarction
Authors: Liu Qi , Shi Rui-Juan , Zhang Yi-Man , Cheng Yi-Heng , Yang Bo-Sen , Zhang Yi-Ke , Huang Bao-Tao , Chen Mao
Published: November 2022

Aims

To investigate the risk factors, clinical features, and prognostic factors of patients with premature acute myocardial infarction (AMI).

Materials and methods

A retrospective cohort study of patients with AMI included in data from the West China Hospital of Sichuan University from 2011 to 2019 was divided into premature AMI (aged < 55 years in men and < 65 years in women) and non-premature AMI. Patients’ demographics, laboratory tests, Electrocardiography (ECG), cardiac ultrasound, and coronary angiography reports were collected. All-cause death after incident premature MI was enumerated as the primary endpoint.

Results

Among all 8,942 AMI cases, 2,513 were premature AMI (79.8% men). Compared to the non-premature AMI group, risk factors such as smoking, dyslipidemia, overweight, obesity, and a family history of coronary heart disease (CHD) were more prevalent in the premature AMI group. The cumulative survival rate of patients in the premature AMI group was significantly better than the non-premature AMI group during a mean follow-up of 4.6 years (HR = 0.27, 95% CI 0.22–0.32, p < 0.001). Low left ventricular ejection fraction (LVEF) (Adjusted HR 3.00, 95% CI 1.85–4.88, P < 0.001), peak N-terminal pro-B-type natriuretic peptide (NT-proBNP) level (Adjusted HR 1.34, 95% CI 1.18–1.52, P < 0.001) and the occurrence of in-hospital major adverse cardiovascular and cerebrovascular events (MACCEs) (Adjusted HR 2.36, 95% CI 1.45–3.85, P = 0.001) were predictors of poor prognosis in premature AMI patients.

Conclusion

AMI in young patients is associated with unhealthy lifestyles such as smoking, dyslipidemia, and obesity. Low LVEF, elevated NT-proBNP peak level, and the occurrence of in-hospital MACCEs were predictors of poor prognosis in premature AMI patients.
Case report: Active clinical manifestation of endocardial fibroelastosis in adolescence in a patient with mitral and aortic obstruction–histologic presence of endothelial-to-mesenchymal transformation
Authors: Diaz-Gil Daniel , Carreon Chrystalle Katte , Silva-Gomez Natalia , Benheim Alan E. , Emani Sitaram M. , del Nido Pedro J. , Marx Gerald R. , Friehs Ingeborg
Published: November 2022

This is the first description of active clinical manifestation of endocardial fibroelastosis (EFE) and remodeling of the endocardium via endothelial-to-mesenchymal transformation (EndMT) in an adolescent with Shone’s variant hypoplastic left heart complex (HLHC) and a genetic heterozygous ABL1 variant. While EFE has not been typically associated HLHC or Shone’s syndrome, in this patient flow alterations in the left ventricle (LV), combined with genetic alterations of intrinsic EndMT pathways led to active clinical manifestation of EFE in adolescence. This case emphasizes that new therapies for EFE might need to focus on molecular factors influenced by intrinsic and extrinsic stimuli of EndMT.
Sex differences in atrial remodeling and its relationship with myocardial fibrosis in hypertrophic obstructive cardiomyopathy
Authors: Bi Xuanye , Song Yanyan , Yang Chengzhi , Song Yunhu , Zhao Shihua , Qiao Shubin , Zhang Jinying
Published: November 2022

Background

This study aimed to explore the effect of sex on left atrial (LA) remodeling and its relationship with myocardial fibrosis in patients with hypertrophic obstructive cardiomyopathy (HOCM).

Methods and results

A total of 85 patients with HOCM were enrolled. Myocardial fibrosis was quantified by the collagen volume fraction (CVF) in myocardial samples. The early atrial peak of emptying rate (PER-E) was assessed by LA volume/time (V/t) curves derived from cardiac magnetic resonance (CMR) imaging analysis. The PER-E index was PER-E normalized by left ventricular (LV) filling volume. Patients with HOCM showed a lower PER-E index than healthy controls (P = 0.027). Compared with men, the PER-E (P < 0.001) and the PER-E indexes (P = 0.012) in women were lower. In CVF-stratified subgroups, a sex difference in the PER-E index was eliminated (P > 0.05). The CVF was correlated with the PER-E and PER-E indexes in both sexes (all P-values were <0.05). In multivariate regression analysis, sex (P = 0.007) and CVF (P < 0.001) were independently correlated with PER-E (all P-values were <0.05).

Conclusion

Patients with HOCM presented LA reverse remodeling. Impaired LA function was more common in female patients with HOCM due to their susceptibility to myocardial fibrosis.
Correlation between long-term use of metformin and incidence of NAFLD among patients with type 2 diabetes mellitus: A real-world cohort study
Authors: Huang Kuang-Hua , Lee Chiu-Hsiang , Cheng Yih-Dih , Gau Shuo-Yan , Tsai Tung-Han , Chung Ning-Jen , Lee Chien-Ying
Published: November 2022

Background and aims

Studies have demonstrated that the short-term use of metformin benefits liver function among patients with type 2 diabetes mellitus (T2DM). However, few studies have reported on the effects of long-term metformin treatment on liver function or liver histology. This study investigated the correlation between metformin use and the incidence of nonalcoholic fatty liver disease (NAFLD) among patients with T2DM.

Methods

This population-based study investigated the risk of NAFLD among patients with T2DM who received metformin treatment between 2001-2018. Metformin users and metformin nonusers were enrolled and matched to compare the risk of NAFLD.

Results

After 3 years, the patients who received <300 cDDD of metformin and those with metformin use intensity of <10 and 10–25 DDD/month had odds ratios (ORs) of 1.11 (95% confidence interval [CI] = 1.06–1.16), 1.08 (95% CI = 1.02–1.13), and 1.18 (95% CI = 1.11–1.26) for NAFLD, respectively. Moreover, metformin users who scored high on the Diabetes Complications and Severity Index (DCSI) were at high risk of NAFLD. Patients with comorbid hyperlipidemia, hyperuricemia, obesity, and hepatitis C were also at high risk of NAFLD.

Conclusion

Patients with T2DM who received metformin of <300 cDDD or used metformin at an intensity of <10 and 10–25 DDD/month were at a high risk of developing NAFLD. The results of this study also indicated that patients with T2DM receiving metformin and with high scores on the DCSI were at a high risk of developing NAFLD.
Implicating factors in the increase in cases of central precocious puberty (CPP) during the COVID-19 pandemic: Experience of a tertiary centre of pediatric endocrinology and review of the literature
Authors: Barberi C. , Di Natale V. , Assirelli V. , Bernardini L. , Candela E. , Cassio A.
Published: November 2022

Sexual development is a complex mechanism activated by the hypothalamic-pituitary-gonadal axis. Over the last one hundred years there has been a decline in the age at puberty onset in industrialised countries. Some Italian studies showed an increase in diagnoses of Central Precocious Puberty (CPP) during the COVID-19 pandemic. It is thus supposed that in this period there was an increased impact of factors that can influence pubertal development. Our retrospective monocentric study aimed to confirm the existence of this phenomenon and analysed possible related factors. We retrospectively evaluated clinical, laboratory, radiological and ultrasound (US) data of 154 girls referred to our Tertiary Centre of Paediatric Endocrinology from January 2019 to April 2021 for different forms of Precocious Puberty. We subdivided the cases into subgroups according to the final diagnosis: CPP, Early Puberty (EP), isolated thelarche and isolated pubarche. The observation period was subdivided into: Period 1, before lockdown (1 January 2019 – 8 March 2020) and Period 2, lockdown and the following months (9 March 2020 – 30 April 2021). Period 2 was further divided into “restrictive lockdown period” (Period 2.1) (March 2020 – 14 June 2020, in which the schools were closed) and “less restrictive lockdown period” (Period 2.2) (15 June 2020 – 30 April 2021). We analysed data regarding the use of electronic devices before and during lockdown in a group of girls with CPP diagnosed in Period 2 and we compared the data with that of a control group. Our data show an increase in the number of new diagnoses of CPP during lockdown and in the following months, compared with the previous period. We also detected a higher use of PCs and smartphones in girls with CPP diagnosed in Period 2, compared with the control group. The percentage of the presence of endometrial rhyme detected during the pelvic ultrasound was higher in girls with CPP in Period 2, compared with the previous period. Based on our data we assume there was an environmental effect on pubertal timing that calls our attention to factors such as food, use of electronic devices and stress. We will need further studies to better understand this data.