bluuebunny/crossref_metadata_2025 huggingface dataset:
Field Measurement and Mechanical Analysis of Height of the Water Flowing Fracture Zone in Short-Wall Block Backfill Mining beneath the Aquifer: A Case Study in China
Authors: Zhang Yun , Cao Shenggen , Wan Tong , Wang Jijun
Published: October 2018

Short-wall block filling mining (SBBM) technology has become an effective way to recover coal resources beneath the aquifer, which are unsuitable, or cannot be used by long-wall mining, such as corner coal pillars, industrial square pillars, and irregular coal blocks as well as the coal beneath buildings, railways, and water bodies. The SBBM method can not only enhance the recovery ratio but also provide a solution for the environment problems associated with gangues on the surface. However, whether the height of water flowing fractures will reach to the aquifer to cause water loss during SBBM has always been a key problem. Therefore, based on the theory of elastic foundation beam and SBBM characteristics, a mechanical model for calculating the height of a water flowing fracture zone in the overlying strata of SBBM was established, and this model calculated that the height of the water flowing fracture zone was 27.0 m in the experimental working face, and the height of the water flowing fracture zone was measured as 26.8 m according to washing fluid loss in the hole, core damage analysis, and drilling TV imaging detection. The comparison results demonstrated that the calculated value almost fit well with the field-measured data, validating the accuracy of the proposed mechanical model, while the predicted value (48.7 m) in the Regulations of coal mining under building, railways and water-bodies deviates greatly from the measured results. This reveals that the prediction formula in Regulations is not effective in predicting the height of the water flowing fracture zone in SBBM. The present research results are of great significance to further enhancing the recovery ratio of coal resources and improving the water-preserved mining theory.
Psychiatric Comorbidities among People Who Inject Drugs in Hai Phong, Vietnam: The Need for Screening and Innovative Interventions
Authors: Pham Minh Khue , Vallo Roselyne , Duong Thi Huong , Khuat Thi Hai Oanh , Jarlais Don C. Des , Peries Marianne , Le Sao Mai , Rapoud Delphine , Quillet Catherine , Nham Thi Tuyet Thanh , Hoang Thi Giang , Feelemyer Jonathan , Vu Hai Vinh , Moles Jean-Pierre , Pham Thu Xanh , Laureillard Didier , Nagot Nicolas , Michel Laurent , Study Team DRIVE
Published: October 2018

The objective of this study is to describe psychiatric comorbidities, associated factors, and access to psychiatric assessment and care in a cohort of people who inject drugs (PWID) in Hai Phong, Vietnam. Mental health was assessed after 12 months’ follow-up using the Mini International Neuropsychiatric Interview questionnaire (MINI 5.0.0). PWID medical history, drug use, and sociodemographic and clinical characteristics were also collected. Among 188 PWID who participated in the assessment, 48 (25.5%) had at least one psychiatric disorder and 19 (10.1%) had 2 or more psychiatric disorders. The most common current psychiatric disorders were major depressive episode (12.2%) and psychotic disorder (4.8%), reaching 10.1% for the latter when lifetime prevalence was considered. Females were more likely than males to have at least one psychiatric disorder, a major depressive disorder, or an anxiety disorder. Methamphetamine use was associated with an increased risk of presenting a lifetime psychotic syndrome. Problematic alcohol consumption was associated with an increased risk of having at least one psychiatric disorder. Psychiatric comorbidities are frequent among PWID in Vietnam. These results highlight the need for routine assessment and innovative interventions to address mental health needs among PWID. Community-based interventions targeting mental health prevention and care should be strongly supported.
The Juggler of Notre Dame and the Medievalizing of Modernity
Authors: Ziolkowski Jan M.
Published: October 2018

This ambitious and vivid study in six volumes explores the journey of a single, electrifying story, from its first incarnation in a medieval French poem through its prolific rebirth in the nineteenth and twentieth centuries. The Juggler of Notre Dame tells how an entertainer abandons the world to join a monastery, but is suspected of blasphemy after dancing his devotion before a statue of the Madonna in the crypt; he is saved when the statue, delighted by his skill, miraculously comes to life.

Jan Ziolkowski tracks the poem from its medieval roots to its rediscovery in late nineteenth-century Paris, before its translation into English in Britain and the United States. The visual influence of the tale on Gothic revivalism and vice versa in America is carefully documented with lavish and inventive illustrations, and Ziolkowski concludes with an examination of the explosion of interest in The Juggler of Notre Dame in the twentieth century and its place in mass culture today. Volume 4 examines the famous Le jongleur de Notre Dame by the French composer Jules Massenet, which took Europe by storm after premiering in 1902 and then crossed the Atlantic to the impresario Oscar Hammerstein and the diva Mary Garden, who gave the opera new legs as a female juggler.

Presented with great clarity and simplicity, Ziolkowski's work is accessible to the general reader, while its many new discoveries will be valuable to academics in such fields and disciplines as medieval studies, medievalism, philology, literary history, art history, folklore, performance studies, and reception studies.
100 Years of Progress in Polar Meteorology
Authors: Walsh John E. , Bromwich David H. , Overland James. E. , Serreze Mark C. , Wood Kevin R.
Published: October 2018

The polar regions present several unique challenges to meteorology, including remoteness and a harsh environment. We summarize the evolution of polar meteorology in both hemispheres, beginning with measurements made during early expeditions and concluding with the recent decades in which polar meteorology has been central to global challenges such as the ozone hole, weather prediction, and climate change. Whereas the 1800s and early 1900s provided data from expeditions and only a few subarctic stations, the past 100 years have seen great advances in the observational network and corresponding understanding of the meteorology of the polar regions. For example, a persistent view in the early twentieth century was of an Arctic Ocean dominated by a permanent high pressure cell, a glacial anticyclone. With increased observations, by the 1950s it became apparent that, while anticyclones are a common feature of the Arctic circulation, cyclones are frequent and may be found anywhere in the Arctic. Technology has benefited polar meteorology through advances in instrumentation, especially autonomously operated instruments. Moreover, satellite remote sensing and computer models revolutionized polar meteorology. We highlight the four International Polar Years and several high-latitude field programs of recent decades. We also note outstanding challenges, which include understanding of the role of the Arctic in variations of midlatitude weather and climate, the ability to model surface energy exchanges over a changing Arctic Ocean, assessments of ongoing and future trends in extreme events in polar regions, and the role of internal variability in multiyear-to-decadal variations of polar climate.
Climate and the Global Famine of 1876–78
Authors: Singh Deepti , Seager Richard , Cook Benjamin I. , Cane Mark , Ting Mingfang , Cook Edward , Davis Michael
Published: October 2018

From 1875 to 1878, concurrent multiyear droughts in Asia, Brazil, and Africa, referred to as the Great Drought, caused widespread crop failures, catalyzing the so-called Global Famine, which had fatalities exceeding 50 million people and long-lasting societal consequences. Observations, paleoclimate reconstructions, and climate model simulations are used 1) to demonstrate the severity and characterize the evolution of drought across different regions, and 2) to investigate the underlying mechanisms driving its multiyear persistence. Severe or record-setting droughts occurred on continents in both hemispheres and in multiple seasons, with the “Monsoon Asia” region being the hardest hit, experiencing the single most intense and the second most expansive drought in the last 800 years. The extreme severity, duration, and extent of this global event is associated with an extraordinary combination of preceding cool tropical Pacific conditions (1870–76), a record-breaking El Niño (1877–78), a record strong Indian Ocean dipole (1877), and record warm North Atlantic Ocean (1878) conditions. Composites of historical analogs and two sets of ensemble simulations—one forced with global sea surface temperatures (SSTs) and another forced with tropical Pacific SSTs—were used to distinguish the role of the extreme conditions in different ocean basins. While the drought in most regions was largely driven by the tropical Pacific SST conditions, an extreme positive phase of the Indian Ocean dipole and warm North Atlantic SSTs, both likely aided by the strong El Niño in 1877–78, intensified and prolonged droughts in Australia and Brazil, respectively, and extended the impact to northern and southeastern Africa. Climatic conditions that caused the Great Drought and Global Famine arose from natural variability, and their recurrence, with hydrological impacts intensified by global warming, could again potentially undermine global food security.
Orbitally stabilizing control for the underactuated translational oscillator with rotational actuator system: Design and experimentation
Authors: Liu Chuande , Gao Bingtuan , Zhao Jianguo , Shah Syed Awais Ali
Published: October 2018

Underactuated translational oscillator with rotational actuator systems are simplified mechatronic systems introduced to investigate the despin maneuver phenomenon for dual-spin spacecrafts in mechanical engineering. The conventional research work for translational oscillator with rotational actuator systems mainly focuses on stabilizing control of equilibrium points. In this article, an orbitally stabilizing control strategy is proposed to steer oscillating movements of a translational oscillator with rotational actuator system. Based on the natural periodicity of translational oscillator with rotational actuator system self-sustained oscillation, the dynamics is analyzed to derive the periodically orbital functions of the translational oscillator with rotational actuator system. Then, a proper control Lyapunov function following the principle of energy conservation is designed to obtain orbitally stabilizing controller for target periodical oscillation orbits of the translational oscillator with rotational actuator system. Finally, the validity of the presented control strategy is demonstrated via the simulations and experiments.
Gremlin 1 blocks vascular endothelial growth factor signaling in the pulmonary microvascular endothelium
Authors: Rowan Simon C. , Piouceau Lucie , Cornwell Joanna , Li Lili , McLoughlin Paul
Published: October 2018

The bone morphogenetic protein (BMP) antagonist gremlin 1 plays a central role in the pathogenesis of hypoxic pulmonary hypertension (HPH). Recently, non‐canonical functions of gremlin 1 have been identified, including specific binding to the vascular endothelial growth factor receptor‐2 (VEGFR2). We tested the hypothesis that gremlin 1 modulates VEGFR2 signaling in the pulmonary microvascular endothelium.

We examined the effect of gremlin 1 haploinsufficiency on the expression of VEGF responsive genes and proteins in the hypoxic (10% O2) murine lung in vivo. Using human microvascular endothelial cells in vitro we examined the effect of gremlin 1 on VEGF signaling.

Gremlin 1 haploinsufficiency (Grem1+/–) attenuated the hypoxia‐induced increase in gremlin 1 observed in the wild‐type mouse lung. Reduced gremlin 1 expression in hypoxic Grem1+/– mice restored VEGFR2 expression and endothelial nitric oxide synthase (eNOS) expression and activity to normoxic values. Recombinant monomeric gremlin 1 inhibited VEGFA‐induced VEGFR2 activation, downstream signaling, and VEGF‐induced increases in Bcl‐2, cell number, and the anti‐apoptotic effect of VEGFA in vitro.

These results show that the monomeric form of gremlin 1 acts as an antagonist of VEGFR2 activation in the pulmonary microvascular endothelium. Given the previous demonstration that inhibition of VEGFR2 causes marked worsening of HPH, our results suggest that increased gremlin 1 in the hypoxic lung, in addition to blocking BMP receptor type‐2 (BMPR2) signaling, contributes importantly to the development of PH by a non‐canonical VEGFR2 blocking activity.
Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model
Authors: Morales-Ortíz Jessica , Deal Victoria , Reyes Fiorella , Maldonado-Martínez Gerónimo , Ledesma Nahomy , Staback Franklin , Croft Cheyanne , Pacheco Amanda , Ortiz-Zuazaga Humberto , Yost C. Christian , Rowley Jesse W. , Madera Bismark , John Alex St. , Chen Junmei , Lopez Jose , Rondina Matthew T. , Hunter Robert , Gibson Angelia , Washington A. Valance
Published: October 2018

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)–like transcript 1 (TLT-1) is found on platelets, binds fibrinogen, and mediates clot formation. We hypothesized that platelets use TLT-1 to manage the progression of ALI/ARDS. Here we retrospectively measure plasma levels of soluble TLT-1 (sTLT-1) from the ARDS Network clinical trial and show that patients whose sTLT-1 levels were >1200 pg/mL had nearly twice the mortality risk as those with <1200 pg/mL (P < .001). After correcting for confounding factors such as creatinine levels, Acute Physiology And Chronic Health Evaluation III scores, age, platelet counts, and ventilation volume, sTLT-1 remains significant, suggesting that sTLT-1 is an independent prognostic factor (P < .0001). These data point to a role for TLT-1 during the progression of ALI/ARDS. We use a murine lipopolysaccharide-induced ALI model and demonstrate increased alveolar bleeding, aberrant neutrophil transmigration and accumulation associated with decreased fibrinogen deposition, and increased pulmonary tissue damage in the absence of TLT-1. The loss of TLT-1 resulted in an increased proportion of platelet-neutrophil conjugates (43.73 ± 24.75% vs 8.92 ± 2.4% in wild-type mice), which correlated with increased neutrophil death. Infusion of sTLT-1 restores normal fibrinogen deposition and reduces pulmonary hemorrhage by 40% (P ≤ .001) and tissue damage by 25% (P ≤ .001) in vivo. Our findings suggest that TLT-1 uses fibrinogen to govern the transition between inflammation and hemostasis and facilitate controlled leukocyte transmigration during the progression of ARDS.
The phase 3 DUO trial: duvelisib vs ofatumumab in relapsed and refractory CLL/SLL
Authors: Flinn Ian W. , Hillmen Peter , Montillo Marco , Nagy Zsolt , Illés Árpád , Etienne Gabriel , Delgado Julio , Kuss Bryone J. , Tam Constantine S. , Gasztonyi Zoltán , Offner Fritz , Lunin Scott , Bosch Francesco , Davids Matthew S. , Lamanna Nicole , Jaeger Ulrich , Ghia Paolo , Cymbalista Florence , Portell Craig A. , Skarbnik Alan P. , Cashen Amanda F. , Weaver David T. , Kelly Virginia M. , Turnbull Barry , Stilgenbauer Stephan
Published: October 2018

Duvelisib (also known as IPI-145) is an oral, dual inhibitor of phosphatidylinositol 3-kinase δ and γ (PI3K-δ,γ) being developed for treatment of hematologic malignancies. PI3K-δ,γ signaling can promote B-cell proliferation and survival in clonal B-cell malignancies, such as chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). In a phase 1 study, duvelisib showed clinically meaningful activity and acceptable safety in CLL/SLL patients. We report here the results of DUO, a global phase 3 randomized study of duvelisib vs ofatumumab monotherapy for patients with relapsed or refractory (RR) CLL/SLL. Patients were randomized 1:1 to oral duvelisib 25 mg twice daily (n = 160) or ofatumumab IV (n = 159). The study met the primary study end point by significantly improving progression-free survival per independent review committee assessment compared with ofatumumab for all patients (median, 13.3 months vs 9.9 months; hazard ratio [HR] = 0.52; P < .0001), including those with high-risk chromosome 17p13.1 deletions [del(17p)] and/or TP53 mutations (HR = 0.40; P = .0002). The overall response rate was significantly higher with duvelisib (74% vs 45%; P < .0001) regardless of del(17p) status. The most common adverse events were diarrhea, neutropenia, pyrexia, nausea, anemia, and cough on the duvelisib arm, and neutropenia and infusion reactions on the ofatumumab arm. The DUO trial data support duvelisib as a potentially effective treatment option for patients with RR CLL/SLL. This trial was registered at www.clinicaltrials.gov as #NCT02004522.
tTEM — A towed transient electromagnetic system for detailed 3D imaging of the top 70 m of the subsurface
Authors: Auken Esben , Foged Nikolaj , Larsen Jakob Juul , Lassen Knud Valdemar Trøllund , Maurya Pradip Kumar , Dath Søren Møller , Eiskjær Tore Tolstrup
Published: October 2018

There is a growing need for detailed investigation of the top 30–50 m of the subsurface, which is critical for infrastructure, water supply, aquifer storage and recovery, farming, waste deposits, and construction. Existing geophysical methods are capable of imaging this zone; however, they have limited efficiency when it comes to creating full 3D images with high resolution over dozens to hundreds of hectares. We have developed a new and highly efficient towed transient electromagnetic (tTEM) system, which is capable of imaging the subsurface up to depth of 70 m at a high resolution, horizontally and vertically. Towed by an all-terrain vehicle, the system uses a [Formula: see text] transmitter coil and has a [Formula: see text]-component receiver placed at 9 m offset from the transmitter. The tTEM uses dual transmitter moment (low and high moment) measurement sequence to obtain the early and late time gates corresponding to shallow and deep information about the subsurface layers. The first bias-free gate is as early as [Formula: see text] from beginning of the ramp ([Formula: see text] after end of ramp). Data are processed and inverted using methods directly adopted from airborne electromagnetics. The system has been successfully used in Denmark for various purposes, e.g., mapping raw materials, investigating contaminated sites, and assessing aquifer vulnerability. We have also used the tTEM system in the Central Valley of California (United States) for locating artificial recharge sites and in the Mississippi Delta region, to map complex subsurface geology in great detail for building hydrogeologic models.
First-in-Human Phase I, Dose-Escalation and -Expansion Study of Telisotuzumab Vedotin, an Antibody–Drug Conjugate Targeting c-Met, in Patients With Advanced Solid Tumors
Authors: Strickler John H. , Weekes Colin D. , Nemunaitis John , Ramanathan Ramesh K. , Heist Rebecca S. , Morgensztern Daniel , Angevin Eric , Bauer Todd M. , Yue Huibin , Motwani Monica , Parikh Apurvasena , Reilly Edward B. , Afar Daniel , Naumovski Louie , Kelly Karen
Published: October 2018

Purpose

This first-in-human study evaluated telisotuzumab vedotin (Teliso-V), formerly called ABBV-399, an antibody–drug conjugate of the anti–c-Met monoclonal antibody ABT-700 and monomethyl auristatin E.

Materials and Methods

For dose escalation, three to six patients with advanced solid tumors were enrolled in eight cohorts (0.15 to 3.3 mg/kg). The dose-expansion phase enrolled patients with non–small-cell lung cancer (NSCLC) with c-Met–overexpressing tumors (c-Met positive; immunohistochemistry membrane H-score ≥ 150). Patients received Teliso-V monotherapy intravenously on day 1 once every 3 weeks. Safety, tolerability, pharmacokinetics, and maximum tolerated dose were determined.

Results

Forty-eight patients were enrolled (median age, 65 years; 35.4% NSCLC; median four prior therapies). One patient each in the 3.0-mg/kg (n = 9) and 3.3-mg/kg (n = 3) cohorts experienced dose-limiting toxicities. Although the maximum tolerated dose was not formally identified, the recommended phase II dose was defined as 2.7 mg/kg on the basis of overall safety and tolerability. The most frequent treatment-emergent adverse events (any grade) were fatigue (42%), nausea (27%), constipation (27%), decreased appetite (23%), vomiting (21%), dyspnea (21%), diarrhea (19%), peripheral edema (19%), and neuropathy (17%). The most frequent Teliso-V–related grade ≥ 3 adverse events were fatigue, anemia, neutropenia, and hypoalbuminemia (4% each). Teliso-V and total antibody pharmacokinetics were approximately dose proportional, with a mean harmonic half-life of 2 to 4 days each. Prospective screening identified 35 (60%) of 58 patients with c-Met–positive NSCLC. Of 16 patients with c-Met–positive NSCLC who were treated with Teliso-V 2.4 to 3.0 mg/kg, three (18.8%; 95% CI, 4.1% to 45.7%) achieved a partial response (median response duration, 4.8 months; median progression-free survival, 5.7 months; 95% CI, 1.2 months to 15.4 months). No other patients experienced a response.

Conclusion

Teliso-V monotherapy demonstrated favorable safety and tolerability profiles, with encouraging evidence of antitumor activity in patients with c-Met–positive NSCLC.
Anesthetic Implications of a Patient With Kniest Dysplasia and Mitochondrial Disease: A Case Report
Authors: Salik Irim , Kubal Keshar , Barst Samuel
Published: October 2018

Kniest dysplasia, or metatropic dysplasia type II, is a rare chondrodysplasia caused by abnormal type II collagen. Clinically, it is characterized by dwarfism, deafness, skeletal derangements, and ocular abnormalities. Mitochondrial diseases produce a spectrum of abnormalities in affected individuals and predominantly impact organs of high energy utilization, including the brain, skeletal muscles, kidneys, and liver. We present the case of a 6-year-old boy with both Kniest dysplasia and underlying mitochondrial disease for examination under anesthesia before cataract surgery. Successful anesthetic management of a patient with Kniest dysplasia and a mitochondrial myopathy is discussed.
The low-down on sleeping down low: pigeons shift to lighter forms of sleep when sleeping near the ground
Authors: Tisdale Ryan K. , Lesku John A. , Beckers Gabriel J. L. , Vyssotski Alexei L. , Rattenborg Niels C.
Published: October 2018

Sleep in birds is composed of two distinct sub-states, remarkably similar to mammalian slow-wave sleep (SWS) and rapid eye movement (REM) sleep. However, it is unclear whether all aspects of mammalian sleep are present in birds. We examined whether birds suppress REM sleep in response to changes in sleeping conditions that presumably evoke an increase in perceived predation risk, as observed previously in rodents. Although pigeons sometimes sleep on the ground, they prefer to sleep on elevated perches at night, probably to avoid nocturnal mammalian ground predators. Few studies to date have investigated how roosting sites affect sleep architecture. We compared sleep in captive pigeons on days with and without access to high perches. On the first (baseline) day, low and high perches were available; on the second day, the high perches were removed; and on the third (recovery) day, the high perches were returned. The total time spent sleeping did not vary significantly between conditions; however, the time spent in REM sleep declined on the low-perch night and increased above baseline when the pigeons slept on the high perch during the recovery night. Although the amount of SWS did not vary significantly between conditions, SWS intensity was lower on the low-perch night, particularly early in the night. The similarity of these responses between birds and mammals suggests that REM sleep is influenced by at least some ecological factors in a similar manner in both groups of animals.
Padrões de comportamento sedentário em adolescentes de um município da região Nordeste do Brasil
Authors: Mendonça Gerfeson , Prazeres Filho Alcides , Barbosa Arthur Oliveira , Farias Júnior José Cazuza
Published: October 2018

O objetivo desse estudo foi descrever os padrões de comportamento sedentário de adolescentes. Trata-se de um estudo transversal com 656 adolescentes (10 – 14 anos de idade) de escolas públicas de João Pessoa, Paraíba. O comportamento sedentário foi mensurado por acelerômetro Actigraph GT3X+ (≤ 100 counts/min). Os padrões de comportamento sedentário foram definidos pelo tempo médio (na semana; em dias de meio e final de semana; dentro e fora do horário escolar), número de bouts e breaks diários, e tempo excessivo sedentário (> 8 horas/dia). Os adolescentes permaneceram em média 444,63 min/dia em comportamento sedentário, sendo mais elevado nos dias de meio de semana (448,73 min/dia) comparado aos do final de semana (434,38 min/dia; p = 0,004) e no horário escolar (164,32 min/dia) comparado ao fora da escola (142,21 min/dia; p < 0,001). Apresentaram em média, 96,19 breaks por dia de comportamento sedentário, sendo 98,6% desses em intervalos de curta duração (< 20 minutos). Veri cou-se que 30,2% (IC95%: 26,7-33,7) dos adolescentes passavam > 8 horas/dia em comportamento sedentário. No geral, os do sexo feminino e mais jovens (10 – 11 anos) apresentaram maior número médio de breaks por dia. Os adolescentes mais velhos (12 – 14 anos) apresentaram maior número de bouts longos e os do sexo masculino e classe econômica média-baixa maior número de breaks longos. A exposição dos adolescentes aos comportamentos sedentários foi alta, principalmente nos dias do meio de semana e no horário escolar. A maioria dos bouts e breaks no comportamento sedentário foi realizada em períodos de curta duração, com variações de exposição conforme as características sociodemográficas dos adolescentes.
Structure Detection in Mixed-Integer Programs
Authors: Khaniyev Taghi , Elhedhli Samir , Erenay Fatih Safa
Published: October 2018

Despite vast improvements in computational power, many large-scale optimization problems involving integer variables remain difficult to solve. Certain classes, however, can be efficiently solved by exploiting special structure. One such structure is the singly bordered block-diagonal (BBD) structure that lends itself to Dantzig-Wolfe decomposition, Lagrangian relaxation, and branch and price. We start by introducing a new measure of goodness to capture desired features in BBD structures such as granularity of the structure, homogeneity of the block sizes, and isomorphism of the blocks. We then use it to propose a new approach to identify the best BBD structure inherent in the constraint matrix. The main building block of the proposed approach is the use of a community detection methodology in lieu of graph/hypergraph partitioning methods to alleviate one major drawback of the existing approaches in the literature: predefining the number of blocks. When tested on MIPLIB2003/2010 instances and compared against the state-of-the-art technique, the proposed algorithm is found to identify very good structures and require shorter CPU time to reach comparable bounds, in most cases.
A GRAMATICALIZÃO DA LOCUÇÃO CONJUNTIVA POSTO QUE
Authors: Manolio Adriana
Published: October 2018

Este arquivo objetiva investigar o processo de gramaticalização que originou a locução conjuntiva subortinativa posto que. Assim, traça-se inicialmente uma breve introdução com a fundamentação teórica a respeito da gramaticalização e as diversas concepções concernentes a esse processo de mudança linguística. Em seguida, será investigado o processo histórico de gramaticalização do posto que e será analisada a trajetória do deslizamento de significado dessa locução, cujo valor semântico no português contemporâneo está sendo alterado de concessivo para causal. Afinal, verifica-se que, pelos dados analisados, a locução conjuntiva posto que originou-se de um processo de gramaticalização, bem como que ela está em trajetória de mudança semântica.
AS FORMAS PRONOMINAIS TU, VOCÊ E O(A) SENHOR(A) NO PORTUGUÊS FALADO EM CAMETÁ – ESTADO DO PARÁ, EM UMA ABORDAGEM SOCIOFUNCIONALISTA
Authors: Silva Costa Raquel Maria da
Published: October 2018

RESUMO: Este trabalho apresenta um estudo sobre a alternância das formas pronominais de referência à segunda pessoa, Tu/Você/o(a) Senhor(a), na função de sujeito, no português falado na zona urbana de Cametá/PA. Adota a interface entre a Teoria da Variação e Mudança Linguística e o Funcionalismo linguístico, gerando dessa forma uma abordagem caracterizada no âmbito dos estudos linguísticos de sociofuncionalista. Objetiva analisar o papel de fatores linguísticos e extralinguísticos ou sociais como motivadores do comportamento variável de tu/você/o(a) senhor(a) em função de sujeito. O corpus contém dados de interações face a face de 16 grupos focais, cada qual constituído por 04 sujeitos participantes, sendo um o informante-base, todos cametaenses, estratificados de acordo com a faixa etária (21 a 29 anos e 32 a 42 anos), o sexo/gênero e o nível de escolaridade (médio e superior), totalizando 64 participantes. Na fala dos 16 informantes-base, obtivemos 527 dados de uso de Tu, Você e o(a) Senhor(a), os quais foram analisados quantitativamente e qualitativamente. Os resultados apontaram 307 ocorrências da forma pronominal tu, 182 de você e apenas 38 da forma o(a) senhor(a), o que corresponde, respectivamente, a 58.3%, 34.5% e 7.2%. No âmbito do Sociofuncionalismo, ao avaliarmos a correlação entre variável dependente e variáveis independentes pelo princípio da marcação, verificamos que a forma tu é menos marcada na linguagem cametaense, considerando-se a distribuição de frequência e a complexidade estrutural. A forma você, de menor frequência e maior complexidade estrutural e cognitiva, por isso mais marcada, encontra predileção, nos contextos mais marcados.
ECG of the month
Authors: Richley Dave
Published: October 2018

Dave Richley presents an ECG for you to analyse
Assessment of Knowledge of Antenatal Mothers Regarding Selected Health Problems of Complicated Pregnancy- A Cross Sectional Study
Authors: Johncyrani R. , Arulappan Judie
Published: October 2018

Pregnancy and child birth are common and highly important aspects of women’s life. The focus of midwifery is on the care of essentially healthy women, and the care extends to women with social, medical or obstetric risk factors. A descriptive study to assess the knowledge of antenatal mothers on selected health problems complicating pregnancy was conducted. 100 antenatal mothers were selected through simple random sampling method. Among 100 antenatal mothers, 83% had inadequate knowledge and 17% had moderately adequate knowledge. There was highly significant association between the knowledge of antenatal mothers and their demographic variables such as educational status, occupation, and monthly income. It is reported that many of the antenatal mothers were having poor knowledge of selected health problems complicating pregnancy and its clinical manifestation and risk factors. Hence, it is necessary to create awareness among antenatal mothers which might improve their health seeking behaviors. This can be achieved by giving health education to the antenatal mothers. So the researcher had given instructional manual to improve knowledge regarding selected health problems complicating pregnancy which included iron deficiency anemia, gestational diabetes mellitus and pregnancy induced hypertension.
The Effect of Explicit and Implicit Instructions and Sleep on Consolidation of the Accuracy of Elements of a Fine Motor Skill
Authors: Daghighe Rezaie Saeed , Saberi Kakhki Alireza , Sohrabi Mehdi , Shahabi Kaseb Mohammadreza
Published: October 2018

Two processes are suggested for intervention in the learning of motor skills. These include explicit process in which the performer consciously knows the acquisition of the skill and the other one is an implicit process in which the performer has no conscious knowledge of acquiring the skill. The purpose of this study was to investigate the effect of explicit and implicit instructions and sleep on the performance of the fine motor skill. Participants in this study included 30 right-handed volunteer students with a good sleep quality, aged between 18-25 years old. They were randomly divided into two homogeneous explicit (N = 15) and implicit (N = 15) groups based on Purdue Fine Motor Skill Test and Simple Reaction Time. Each group participated in a three-time round at six in the afternoon, 12 midday on the same day, and at eight o'clock next morning in a Timed Motor Sequences Task. The data was analyzed by ANOVA with repeated measures. The results showed that in the accuracy of the short elements, stabilization was done but promotion was not observed but there was no change in the accuracy of the long elements and there was no significant difference between groups.
Cytogenetic Analysis of A Hoverfly Eristalis tenax (Diptera: Syrphidae)
Authors: Khajuria Manvi , Ayoub Bhatti Arshad , Tripathi N.K.
Published: October 2018

Karyotypic, morphometric and meiotic details of a hoverfly, Eristalis tenax belonging to subfamily Eristalinae of family Syrphidae were studied during present investigation. This species is commonly known as drone fly due to its resemblance with the drones of honey bees. These are good pollinators and their larvae are called rat tailed maggots due to the presence of a long posterior tube for breathing. It showed diploid chromosome number 2n=12 (10+XY) in males. The sex mechanism is found to be XY, X is subtelocentric and Y is telocentric. Meiotic observations included leptotene, diplotene, metaphase-I and metaphase-II. Present studies will help to solve taxonomic problems with in the family Syrphidae and in general understanding of the course of evolution in order Diptera.
A carbohydrate-derived trifunctional scaffold for medicinal chemistry library synthesis
Authors: Resende Diana I. S. P. , Estévez Amalia M. , Alker Andre M. , Martin Rainer E. , Wessel Hans Peter
Published: October 2018

For the generation of compound libraries for drug discovery a central scaffold containing three exit vectors with defined chirality was devised starting from commercially available tri-O-acetyl-glucal. Surprisingly, the reaction of a 4-O-mesylate with sodium azide did not lead to the expected 4-azido-4-deoxy derivative but to a 3-azido-3-deoxy regioisomer via intermediate epoxide formation. The absolute stereochemical configuration of the final tetrahydropyran building block was proven by X-ray crystallography. This scaffold endowed with a carboxylic acid, a secondary alcohol, and an azide functionality may be connected to a DNA tag at any of the three distinct exit vectors, thus providing ready access to several different compound libraries.Â
Nutritional Properties of Native Plants and Traditional Foods from the Central United States
Authors: Kindscher Kelly , Martin Leanne , Corbett Steve , Lafond David
Published: October 2018

Traditional foods of indigenous people are a potential untapped source for providing nutritious dietary options in the modern world. The rising popularity of indigenous foods such as amaranth in recent years suggests that these foods can become a popular part of a healthy diet in the United States. Traditional knowledge of indigenous people can form the basis for using wild food resources. This research provides data on 50 plant species common to the central United States that are abundant sources of dietary protein and fiber, and used traditionally by Native American tribes. Many species show promise with high amounts of protein and fiber being found in lamb’s quarters, nettles, grass seeds, and buffalo gourd seeds. These results honor traditional knowledge. In addition, many of these species could be cultivated using techniques similar to those existing for commercial grains and vegetables. Seeds and/or greens of these wild plants could easily be incorporated into the diets of many more people, improving modern diets, and the nutritional quality of food products.
FEMALE LEADERSHIP AND SOCIAL WELFARE POLICY: CASE STUDIES FROM THREE REGIONS IN INDONESIA (SURABAYA, KUTAI KERTANEGARA AND SOUTH MINAHASA)
Authors: Bayo Longgina Novadona
Published: October 2018

After the fall of Soeharto Regime in 1998, the Reform Era in Indonesia began by promoted freedom and autonomy. The centralized approach based on the New Order’s Act No. 5/1974 was replaced by the Act No. 22/1999 on Local Government Autonomy by gave considerable authority to regencies (kabupaten) and municipalities (kota or kotamadya). Some of the scholars labelled the Act No. 22/1999 as “one of the most radical decentralization programs attempted anywhere in the world” (Aspinall 2003: 3). Several years later Act No. 22/1999 was replaced by Act No. 32/2004. Some scholars have suggested that Act No. 32/2004 indicates “recentralization” in the sense that it strengthens the central government by giving it a degree of control over administrative and ﬁscal matters (Pratikno 2009: 57; Buehler 2009: 102). However, the significant point in the Act No. 32/2004 which introduced direct local head election mechanism for electing local government head was the structural opportunities for women to take greater leadership in local politics. As result, the direct local election from 2005 until 2017 demonstrates the trend of increasing number female political leaders elected as governors/regents/mayors in local politics in post-Suharto (see figure 1).
Wspieranie rozwoju kreatywności dziecka jako element praktyki logopedycznej. O możliwych związkach logopedii z pedagogiką twórczości
Authors: Galewska-Kustra Marta
Published: October 2018

Logopedics and pedagogy of creativity are the disciplines whose areas of research interests are different. Some may say that they have nothing in common. The main tasks and goals undertaken by the speech therapists are different from those by creativity educators. Speech therapists’ work is directly connected with prevention and therapy of speech disorders. Creativity educator supports, enhances and develops creative abilities, creative attitude of children, adolescents and adults. However, the goals of creativity education may become a part of the speech therapy practice. This article is an attempt to illustrate the possible relations between pedagogy of creativity and logopedics, and to show the practical ways in which the practice of speech therapy may become an opportunity to develop children’s creativity.
Rozwój mowy i komunikacji dziecka z uszkodzonym słuchem
Authors: Olempska-Wysocka Magdalena
Published: October 2018

The article treats on complexity of speech development, communication process of child with damaged hearing. Article emphasizes factors defining different language and communication competences. Hearing impairment leads to self-expression being delayed. Mentioned delays, could be quantitative (active and passive vocabulary, subordinate to the chronological age of the child) and qualitative (numerous, different disorders of articulation, semantic errors, problems with understanding simple commands).
Wkład antropologii kulturowej w studia nad niepełnosprawnością
Authors: Borowska-Beszta Beata
Published: October 2018

Interdisciplinary studies on disability are conducted in the world by scholars from different disciplines and sub-disciplines, including special education. This article deals with an analysis of the evolution of the concept of disability studies and its’ implementation in anthropology that was narrowed to cultural anthropology, primarily of American roots with references to British social anthropology. The basic question, which I answer from the perspective of the cultural anthropologists, is formulated as follows: why cultural anthropology is important in the disability studies? I give answers in the context of: ontological, epistemological, rhetorical and political issues. Anthropological analyzes are preceded by definitions of disability studies after Stteven aylor, Bonnie Shoultz, Pamela Walker; Colin Barnes; Dan Goodley; Sharon L. Snyder; David T. Mitchell and Ronald J. Berger.
Mechanizmy motywacji a wybór strategii uczenia się uczniów szkół gimnazjalnych z i bez specyficznych trudności w uczeniu się
Authors: Kucharczyk Izabella , Dłużniewska Agnieszka
Published: October 2018

The purpose of this article is to present the results of research concern setting of motivated and cognitive strategies in learning goals achieving by students with and without dyslexia in secondary school. The study included 110 students studying in secondary schools in the Mazovian region. The study used questionnaire Goal Orientations and Learning Strategies Survey (GOAL-S) M. Dowson and D.M. McInerney (2004) in the Polish adaptation of A. Dłużniewska and I. Kucharczyk. Detailed analysis of the results indicates the relationship between the kind of motivation and choice of cognitive and metacognitive strategies of learning. The current study allows to extract factors that are important in achieving success in academic achievements of students with and without special educational needs.
Kultura informacji osób z niepełnosprawnością wzroku w refleksji tyflologiczno-informatologicznej
Authors: Czerwińska Małgorzata
Published: October 2018

The subject of this paper is the specificity of the information space of persons with visual disabilities as a component of their information culture, according to the concept proposed by M. Kisilowska. Based on systematic analysis of documents and long years of participative observations, the deliberations focus on legal solutions governing the access of persons with visual disabilities to information, the navigation and cognition spheres of a blind information user and the specificity of providing information, in particular the Braille system, tactile graphics, audio description, alternative materials and augmentative technologies. The deliberations highlight obstacles in accessing information by persons with visual disabilities and suggest both practical solutions and research proposals for a complex analysis of the information culture of persons with visual disabilities in Poland.
Słuchowo-językowe funkcjonowanie dzieci bilateralnie zaimplantowanych wszczepem ślimakowym w trybie sekwencyjnym, doniesienie wstępne
Authors: Magierska-Krzysztoń Magdalena
Published: October 2018

Severe hearing damage in the prenatal period or when the baby is born is a disability that significantly impairs the correct functioning in the society of hearing people. A particularly perceptible consequence of severe hearing impairment is the lack or significant delay in the development of speech and language acquisition. Thanks to the use of cochlear implants, the Program Chirurgicznego Leczenia Głuchoty Metodą Wszczepów Ślimakowych [Program of Surgical Treatment of Deafness With the Method of Cochlear Implantation] allows children with perceptive deafness for the access to speech sounds through the auditory pathway. It gives them an opportunity to develop speech and language and in the future – the ability to satisfactorily communicate with other people. The study covered 54 born-deaf children, bilaterally implanted in the sequential mode. The implantation was performed at the Department of Otolaryngology and Laryngological Oncology of the Poznan University of Medical Sciences. The results indicate a constant, dynamic increase of auditory and linguistic-communication skills in the examined group.
Od wczesnych zwiastunów autyzmu po przywiązanie – rozwój relacji społecznych dzieci ze spektrum autyzmu w kontaktach z bliskimi
Authors: Winczura Barbara
Published: October 2018

Autism is a vast developmental disorder with significant delays and problems in participation in alternate social interactions. Studies show that nearly half of the population with various forms of autism participates in social life, although their profile of emotional and social deficits remains highly diversified. Impairment within a social sphere includes a limited disposition and ability to recognize, to understand and to engage in human contact and interpersonal communication. Parents /guardians are the first observers of disturbing behaviors of a child and the first initiators of building a close relationship with their offspring. Their observations are the determinants of the criteria of early detection of autism spectrum disorders. The biggest problem for parents is the inability of their children with autism to show affection. The goal of this article is to show the development profile of social relationships of young children with autism in contacts with their relatives and the analysis of conditions in the child – parent attachment relationship in this group of disorders.
Correlating topology and thermodynamics to predict protein structure sensitivity to point mutations
Authors: Rodriguez Paula Milan , Stratmann Dirk , Duprat Elodie , Papandreou Nikolaos , Acuna Ruben , Lacroix Zoé , Chomilier Jacques
Published: October 2018

The relation between distribution of hydrophobic amino acids along with protein chains and their structure is far from being completely understood. No reliable method allows ab initio prediction of the folded structure from this distribution of physicochemical properties, even when they are highly degenerated by considering only two classes: hydrophobic and polar. Establishment of long-range hydrophobic three dimension (3D) contacts is essential for the formation of the nucleus, a key process in the early steps of protein folding. Thus, a large number of 3D simulation studies were developed to challenge this issue. They are nowadays evaluated in a specific chapter of the molecular modeling competition, Critical Assessment of Protein Structure Prediction. We present here a simulation of the early steps of the folding process for 850 proteins, performed in a discrete 3D space, which results in peaks in the predicted distribution of intra-chain noncovalent contacts. The residues located at these peak positions tend to be buried in the core of the protein and are expected to correspond to critical positions in the sequence, important both for folding and structural (or similarly, energetic in the thermodynamic hypothesis) stability. The degree of stabilization or destabilization due to a point mutation at the critical positions involved in numerous contacts is estimated from the calculated folding free energy difference between mutated and native structures. The results show that these critical positions are not tolerant towards mutation. This simulation of the noncovalent contacts only needs a sequence as input, and this paper proposes a validation of the method by comparison with the prediction of stability by well-established programs.
Introduction
Authors: Gabriel Gösta Ingvar
Published: October 2018

The introduction provides the theoretical framework for the volume ranging from Kant’sCritique of Pure Reasonvia Landsberger’s concept ofEigenbegrifflichkeit(conceptual autonomy) to Assyriological research on ancient Near Eastern epistemic practices, especially Van De Mieroop’s recent volumePhilosophy Before the Greeks. Then the introduction explores the field of the history of philosophy with special consideration given to those variants that focus on non-Greek and non-Western versions of philosophy. Thus, it asks whether and how ancient Mesopotamia can be investigated in such a framework. After that the structure of the volume is explained, and a brief summary of each contribution is given. The introduction concludes by thanking the many people who have helped to make this volume possible.