bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect Evaluation of WTO Dispute Settlement Mechanism Based on Artificial Neural Network
Authors: Xu Mengfan
Published: July 2022

In today’s rapid economic development, trade exchanges between countries are increasingly close, and there are inevitable trade frictions that follow as a consequence. The World Trade Organization (WTO) dispute settlement mechanism (DSM) has become a predominant choice to deal with trade frictions for majority of the WTO member states. As part of the process of applying the Sino-US trade friction to the WTO DSM, the rise of US trade protectionism has caused serious damage to the WTO DSM. Also, the DSM similarly exposes its own inherent defects. Hence, the research on improvement of the WTO DSM under the background of trade friction has profound practical value. Based on this background, this paper proposes a framework for the effective evaluation of WTO DSM based on the artificial neural network. The contributions of the paper include the following: (1) Introduction of domestic and foreign scholars’ research on different issues in the WTO DSM, wherein the retaliation mechanism is introduced in detail. Also, it is conducive for further deepening of the purpose and significance of the retaliation system in the WTO DSM. (2) The characteristics and structure of the CNN are introduced, and a suitable evaluation system for analyzing the impact of WTO DSM is constructed. Further, an evaluation model based on the CNN is proposed. (3) As per the dimension principle of CNN interlayer calculation, the network structure parameters are selected considering an optimal comprehensive evaluation index of the network. The results verify the effectiveness of the proposed method. Finally, when compared with the other state-of-the-art network models, it is found that CNN generates the highest evaluation accuracy.
Influencing Factors on the Use of Tetrahydrobiopterin in Patients with Phenylketonuria
Authors: Gao Hui
Published: July 2022

Objective. To explore and analyze the influencing factors of tetrahydrobiopterin therapy in patients with phenylketonuria. Methods. 86 children with phenylketonuria (PKU) diagnosed and treated in our hospital from February 2019 to September 2021 were randomly enrolled. All the children underwent coenzyme hydroxybiopterin and urinary pterin spectrum analysis, and the children with deficiency received gene mutation testing. Results. The results of urine pterin analysis showed that 82 patients had higher urinary N and B contents than the normal reference values, with the N/B slightly higher than the normal B% within the normal range. 4 patients had extremely high urinary N/B and B% <5% and were diagnosed as BH4 deficiency caused by 6-pyruvoyl-tetrahydropterin synthase (PTPS) deficiency, and a combined stress test was performed. The blood Phe level was (720–1200) μmol/L 3 h after Phe loading, and the blood Phe concentration decreased to (120–240) μmol/L 4–6 h after oral administration of 7.5 mg/kg BH4 tablet. After one week of treatment, the blood Phe concentration decreased significantly to 239 ± 173 μmol/L, with a decrease rate of 52.14 ± 25.28%. It shows that the application of tetrahydrobiopterin intervention therapy is effective in patients with PKU. The results of the full-length cDNA analysis of the PTPS gene showed that a total of 4 gene mutations were found. A C ⟶ T substitution occurred at the 259th base, and the 87th proline (Pro) in the coding region was converted to serine (Ser) (P87S). G ⟶ A substitution at base 286 converts aspartic acid (Asp) at position 96 of the coding region to asparagine (Asn) (D96N). A ⟶ G substitution occurs at the 155th base to convert asparagine (Asn) at position 52 of the coding region to serine (Ser) (N52S). G ⟶ C substitution occurs at the 430th base to convert glycine at position 144 (Gly) to arginine (Arg) (G144R). G144R is a new mutation type. The gene mutation types of the 4 patients were P87S/D96N, N52S/G144R, D96N/P87S, and P87S/P87S, all of which were from their parents, which conformed to the law of autosomal recessive inheritance. Conclusion. PKU is caused by the defect of phenylalanine hydroxylase activity in children, which causes phenylalanine metabolism disorder, and tetrahydrobiopterin intervention therapy can affect the activity of phenylalanine hydroxylase, increase the decline rate of blood Phe, significantly reduce the level of phenylalanine in children, and promote intellectual recovery. The dose of tetrahydrobiopterin should be tailored, with small doses for mild phenotypes and long-term treatment using even smaller doses.
Fuzzy Algorithm Based Bionic Optimization Design of Boring Machine Column
Authors: Bo Wang , Mengji Chen , Jinfeng Wei , Jixin Sun , Zhengjie Lu
Published: July 2022

A large-scale CNC boring machine would not be complete without a column. The tortoise shell is chosen as the bionic prototype, and the column structure is optimized using the bionic optimization design approach, using the column of a thg6920 boring machine as the research object. The structural similarity between the completed turtle shell and the boring machine column is 0.796, according to the fuzzy method. The structural optimization and topological optimization of the column imitating turtle shell are carried out with the ANSYS Workbench, and the bionic column model is established, and then the static analysis and modal analysis are carried out. After bionic optimization and topology optimization, the weight of the column is reduced from 87061 kg to 82107 kg, the maximum stress is reduced to 3.8637 MPa, the maximum stress is reduced by 28.9% compared with the original column, and the specific stiffness and specific strength are increased by 20.65% and 29.4%, respectively. The column structure has also achieved good optimization results in stiffness, strength, and stability.
Common Glomerular Diseases in Adult Jordanians: A Single-Center Experience
Authors: Sheyyab Ahmed , Al-thnaibat Mohammad , Zghayer Aseel A. , Alsheyyab Jafar , Hamed Radi
Published: July 2022

The pattern of glomerular diseases has been reported previously with contradictory results. Our primary objective is to assess the relative frequencies of glomerular disease in adult Jordanians and compare it with other institutes. A secondary objective is to assess the contribution of environmental factors, in an industrial city Zarqa, to kidney disease patterns. Methods. A retrospective study was conducted at a referral hospital center in the central region of Jordan. Assessment of native kidney biopsies, pathological reports, and the patients’ characteristics were obtained from electronic medical records. Results. Our study assessed a total of 178 biopsies, of which 106 patients were included achieving the age criterion for adults. The mean age of our patient was 34 ± 12.7. The number of females (53.7%) was slightly more than males (46.3%). The average creatinine at presentation was 198 umol/L. Almost half of the patients had mild renal impairment (50.9%), while the remaining were divided between moderate (26.1%) and severe (27.3%). The indications of kidney biopsy were proteinuria (11.3%), proteinuria (54.7%), and unexplained renal impairment (34%). The leading common glomerular diseases were represented as a group with a relative frequency ranging between 11% and 13%. Both IgA nephropathy (13.2%) and lupus nephritis (12.2%) were the top conditions causing the nephritic syndrome, while focal segmental glomerulosclerosis (12.2%) and minimal change disease (11.3%) were the conditions leading to nephrotic syndrome. Our secondary analysis showed nonstatistically significantly higher glomerular filtration rates in the city of Zarqa, when compared to Amman (median 94 and 54, respectively, U = 469.5, r = 0.08,

p
=
0.491

). Additionally, Zarqa had higher frequency rates of interstitial/tubular nephritis (χ2(1) = 1.17,

p
=
0.279

, Cramér’s

V

 = 0.13. Conclusion. Common glomerular diseases, as reported internationally, were common among Jordanian adults.
Analysis of University Teaching Evaluation in the Era of BD
Authors: Tian Jing
Published: July 2022

College teaching evaluation is an important part of teaching because it not only summarizes the semester's teaching results but also guides the next semester's teaching. However, with the implementation of China's quality-oriented education reform and the arrival of the era of big data (BD), new requirements for college teaching evaluation are being put forward, which also brings many reform conditions. Teaching evaluation in the traditional sense is typically based solely on the course's student scoring data. This method is based on a single data source and thus cannot evaluate the teaching effect comprehensively, objectively or fairly. To address this issue, a teaching evaluation method in colleges and universities operating within the BD environment is proposed. This paper investigates college and university teaching evaluation in the post-BD era. The observed value of the Bartlett sphericity test statistic is 6619.943, and the corresponding probabilitypis nearly equal to 0. If the significance level an is 0.05, the null hypothesis should be rejected because the probabilitypis less than the significance level a, indicating that the correlation coefficient matrix cannot be the unit matrix. This also implies that there must be some correlation between the original variables, making factor analysis possible. BD can combine scattered and single evaluation data to create continuous and systematic data. BD can provide a large amount of data support for teaching evaluation, making it more scientific and fair; at the same time, driven by BD, teaching evaluation can return the results of teaching evaluation more quickly.
Novel EPG5 Mutation Associated with Vici Syndrome Gene
Authors: Mahjoubi Frouzandeh , Shabani Samira , Khakbazpour Sogand , Khaligh Akhlaghi Aylar
Published: July 2022

Introduction. Vici syndrome (also known as immunodeficiency with cleft lip/palate, cataract, and hypopigmentation and absent corpus callosum) is considered as a progressive neurodevelopmental multisystem disorder. Till date, only 80 cases, including our patient, with this syndrome have been reported .This syndrome is characterized by agenesis of the corpus callosum, hypopigmentation of the eyes and hair, cataract, cardiomyopathy, combined immunodeficiency, hearing loss, seizures, and additional multisystem involvements which have been reported as case reports in the past. Clinical Manifestation. A 5-year-old girl, who is a product of consanguineous marriage, was referred to our center with developmental delay, optic atrophy, blindness, spasticity, seizure, movement disability, and spasticity. Her magnetic resonance imaging (MRI) test showed agenesis of the corpus callosum and her metabolic test reported normal. Materials and Methods. In our laboratory, blood sample was obtained from the patient. DNA was extracted from lymphocytes, and whole exome sequencing (WES) using next generation Illumina sequencing was performed. Result. A novel (private), homozygous, nonsynonymous mutation c.A3206G (p.Y1069C Het) in EPG5 gene was detected; in continuum, testing for this specific variant in her parents was carried out. DNA sequencing of the PCR-amplified product of the EPG5 exon 17 showed that her parents were heterozygote for this variant. These mutations have not been reported before and therefore classified as variation of unknown significance (VUS). Mutation in this gene is shown to cause autosomal recessive Vici syndrome. Conclusion. Since clinical features of Vici syndrome has overlap, its diagnosis is differential and developmental delay occurs in 98% of reported cases. Vici syndrome can be considered as one of the main causes of developmental delay, and this syndrome can be introduced as a novel group of inherited neurometabolic conditions and congenital disorders.
Relationships of Serum Homocysteine, Vitamin B12, and Folic Acid Levels with Papulopustular Rosacea Severity: A Case‐Control Study
Authors: Chung Bo Young , Kim Hye One , Park Chun Wook , Yang Na Gyeong , Kim Jae Yun , Eun Yun Su , Chung Euy Hyun , Lee Sung Yul , Park Young Lip , Lee Sang Hoon , Heo Nam Hun , Shin Min Jeong , Kim Jung Eun
Published: July 2022

Background. Rosacea is a chronic inflammatory skin disease with a multifactorial etiology. Recently, associations between serum homocysteine (Hcy) levels and inflammatory skin diseases, such as psoriasis and hidradenitis suppurativa, have been reported. However, no study has explored the levels of serum Hcy, folic acid, and vitamin B12 in patients with rosacea. Objective. To investigate serum Hcy, vitamin B12, and folic acid levels in patients with papulopustular rosacea (PPR), we characterized the association of these levels with PPR severity. Methods. This case‐control study included 138 PPR patients and 58 healthy controls. The serum levels of Hcy, vitamin B12, and folic acid were measured. A correlation was assessed between disease severity and serum levels of Hcy, vitamin B12, and folic acid. Results. Serum vitamin B12 and folic acid levels were significantly lower in PPR patients than in the healthy controls (p = 0.011 and p = 0.0173, respectively). Although serum Hcy levels did not significantly differ between PPR patients and healthy controls, PPR severity was positively correlated with serum Hcy levels (p < 0.001). Conclusions. Our results suggest a possible association between hyperhomocysteinemia and vitamin B12 deficiency in patients with PPR.
Ecological Smart City Construction Based on Ecological Economy and Network Governance
Authors: Wu Yue
Published: July 2022

China has paid huge resources and environmental costs in the rapid economic development, which severely restricts China’s sustainable development. As a mesolevel between macro(state) and micro(enterprise), urban management has many features that are different from traditional management. This research mainly discusses the construction of ecological smart city based on ecological economy and network governance. This research analyzes the current situation and problems of urban construction from three aspects: urban ecological economy, urban ecological environment, and urban ecological society. The ecological indicators of smart cities are used to reflect the true situation of the target. In order to facilitate quantitative analysis with the greatest possibility and accuracy, a batch of representative, comprehensive, and quantifiable indicator data is the key. By drawing on the existing literature and implementing it under the circumstances, the selected methods are frequency analysis and theoretical analysis, which are divided into three parts: economy, environment, and society to construct an urban ecological evaluation index system. Under the new network governance environment, the openness of government affairs has become more transparent and time-effective. Moving the government’s work to the network not only enhances the construction of a clean government, but also increases the level of public participation. The main ways of citizen participation created by network governance are carrying out online voting, making anonymous online speeches, and online inquiries about politics, etc. These ways have expanded the traditional government governance methods. Not only that, network governance can make the government’s management process more transparent. In this situation, government activities are carried out under the supervision of citizens, which can alleviate the phenomenon of corruption. After the implementation of the ecological smart city plan, the green coverage rate of the built-up area of City A will increase by 1.8% compared with 2017, showing an upward trend. This research will provide effective guidance for the development of ecological smart cities.
Screening of Risk Factors for Poor Prognosis in Patients with Refractory Epilepsy Secondary to Encephalomalacia
Authors: Zhong Yinjun
Published: July 2022

Objective. The study was aimed at screening the independent prognostic risk factors for refractory epilepsy associated with encephalomalacia (REAE). Methods. Patients with REAE treated in the First People’s Hospital of Linping District from January 2018 to December 2019 were selected. The prognosis was represented by Engel grading. Clinical data of the patients were collected, including age, sex, BMI, lesion sites, number of lesion sites, lesion size, seizure frequency, epilepsy type, and treatment methods. Independent risk factors for poor prognosis were screened by logistic regression analysis. The receiver operating characteristic curve (ROC) was used to evaluate the prognostic efficacy of independent risk factors. Results. A total of 48 patients were included in this study, including 31 patients (64.58%) in the good prognosis group and 17 patients (35.42%) in the poor prognosis group. The mean age of the poor prognosis group was higher than that of the good prognosis group (

P
=
0.002

). The proportion of patients with multisite lesions in the poor prognosis group was higher than that in the good prognosis group (

P
=
0.016

). The proportion of patients with

cerebral
 
malacia
 
lesion
 
diameter
≥
3
 
cm

in the poor prognosis group was higher than that in the good prognosis group (

P
=
0.002

). The proportion of patients with

attack
 
frequency
≥
2
 
times
/
month

in the poor prognosis group was higher than in the good prognosis group (

P
=
0.002

). The proportion of patients receiving surgical treatment in the poor prognosis group was lower than that in the good prognosis group (

P
<
0.001

). Age, number of lesion sites, size of encephalomalacia, and seizure frequency were independent risk factors for the prognosis of patients with REAE (

OR
>
1

,

P
<
0.05

). Surgical treatment was an independent protective factor associated with the prognosis of patients with REAE (

OR
<
1

,

P
<
0.05

). The area under the ROC curve of surgical treatment was 0.83 (

P
=
0.004

). The area under the ROC curve of the size of encephalomalacia was 0.72 (

P
=
0.008

). There was a positive correlation between age and size of encephalomalacia and Engel grade (

r
>
0

,

P
<
0.05

). Surgical treatment was negatively correlated with Engel grade (

r
<
0

,

P
<
0.05

). The number of lesion sites and seizure frequency had no significant correlation with Engel (

P
>
0.05

). The proportion of Engel I patients treated with surgery was higher than that treated with drugs (

P
=
0.001

). The ratio of Engel III and IV patients treated with surgery was lower than that treated with medications (

P
<
0.05

). Conclusion. Age, number of lesion sites, size of encephalomalacia, and seizure frequency are independent risk factors for the prognosis of patients with REAE. Surgical treatment is an independent prognostic factor for patients with REAE. Surgical treatment can significantly improve patient outcomes.
Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review
Authors: Bachheti Rakesh Kumar , Worku Limenew Abate , Gonfa Yilma Hunde , Zebeaman Meseret , Deepti  , Pandey D. P. , Bachheti Archana
Published: July 2022

Cardiovascular diseases (CVDs) are the world’s leading killers, accounting for 30% deaths. According to the WHO report, CVDs kill 17.9 million people per year, and there will be 22.2 million deaths from CVD in 2030. The death rates rise as people get older. Regarding gender, the death rate of women by CVD (51%) is higher than that of men (42%). To decrease and prevent CVD, most people rely on traditional medicine originating from the plant (phytochemicals) in addition to or in preference to commercially available drugs to recover from their illness. The CVD therapy efficacy of 92 plants, including 15 terrestrial plants, is examined. Some medicinal plants well known to treat CVD are, Daucus carota, Nerium oleander, Amaranthus Viridis, Ginkgo biloba, Terminalia arjuna, Picrorhiza kurroa, Salvia miltiorrhiza, Tinospora cordifolia, Mucuna pruriens, Hydrocotyle asiatica, Bombax ceiba, and Andrographis paniculate. The active phytochemicals found in these plants are flavonoids, polyphenols, plant sterol, plant sulphur compounds, and terpenoids. A general flavonoid mechanism of action is to prevent low-density lipoprotein oxidation, which promotes vasodilatation. Plant sterols prevent CVD by decreasing cholesterol absorption in the blood. Plant sulphur compound also prevent CVD by activation of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) and inhibition of cholesterol synthesis. Quinone decreases the risk of CVD by increasing ATP production in mitochondria while terpenoids by decreasing atherosclerotic lesion in the aortic valve. Although several physiologically active compounds with recognized biological effects have been found in various plants because of the increased prevalence of CVD, appropriate CVD prevention and treatment measures are required. More research is needed to understand the mechanism and specific plants’ phytochemicals responsible for treating CVD.
Construction of Teaching Mode of Film and TV Art in Institution of Higher Learning Using Virtual Simulation Technology
Authors: Xiong Wei
Published: July 2022

The modernization of education necessitates the enhancement of instructional quality. This paper begins with a basic overview of the current state of film and television art education and then goes on to examine the current state of film and television art education and develop a virtual simulation-based teaching mode for film and television art. This paper develops an instructional quality evaluation model to assess the feasibility of this teaching mode. In this model, GA is used to optimize BPNN's initial weights and thresholds, reducing the time it takes BPNN to find the weights and thresholds that satisfy the training termination conditions. Improve BPNN's prediction accuracy and convergence speed in relation to instructional quality evaluation results. The evaluation accuracy of this algorithm can reach 94.31 percent, which is 6.35 percent higher than other methods. Furthermore, the use of virtual simulation technology in the teaching of film and television art in higher education institutions can have a significant impact and have far-reaching research implications. The findings of this study can be used to improve the teaching of film and television art in institutions of higher learning.
Assessment of the Relationship between Maxillary Posterior Teeth and Maxillary Sinus Using Cone-Beam Computed Tomography
Authors: Altaweel Alaa Abdelqader , Saad Sowairi Sami Mohammed , Saaduddin Sapri Ahmed Mohammed , Saeedi Sama Abdulelah , Alamri Asalah Hamad , Alnobi Albtoul Ahmed , Fahad ALSharif Maha , Mohsen A Altokhi Ahmed , Abbas Hisham
Published: July 2022

Introduction. Because of the close contact between maxillary sinus and maxillary posterior teeth, procedural errors such as perforation of the sinus may occur during surgical intervention resulting in oroantral communication, which if not corrected, would develop into a fistula. The aim of this study was to evaluate the relationship between maxillary posterior teeth and maxillary sinus floor in a population of the western area of Saudi Arabia, and if age, gender, and size may affect such distance. Materials and Methods. This retrospective study evaluated 539 cone-beam computed tomography (CBCT) radiographs of patients over 20 years of age. Patients were divided into four groups according to age: group I (20–30 years), group II (31–40 years), group III (41–50 years), and group IV (more than 50 years). From coronal and sagittal images of CBCT, the vertical distance between the posterior maxillary root and the maxillary sinus was measured and classified according to its proximity to the maxillary sinus. Results. Gender and size did not significantly affect the distance between maxillary posterior root and maxillary sinus. However, there was a significant increase in this distance with increased age. Mesiobuccal root of the second molar was the nearest root to the maxillary sinus (0.8 ± 1.62,

p
<
0.001

), while the buccal root of the first premolar was the farthest root (5.39 ± 3.26,

p
<
0.001

). Conclusion. Regarding the population of this study, the buccal roots of the second molars are the closest to the sinus floor. Complications associated with maxillary molar extraction and implantation are greater at a younger age. Because the distance between posterior maxillary teeth and maxillary sinus was mostly type 1 (0–2 mm), clinicians are advised to perform CBCT to get a better understanding of the relationship between maxillary posterior roots and maxillary sinus before surgical intervention.
Hydroxysafflor Yellow A (HSYA) Protects Endplate Chondrocytes Against IL-1β-Induced Injury Through Promoting Autophagy
Authors: Zhang Zongyu , Huo Yongfeng , Zhou Zhijing , Zhang Peng , Hu Jun
Published: July 2022

Background. Intervertebral disc degeneration (IDD) refers to intractable pain in patients’ waist and legs, which is caused by internal structural disorder and degeneration of intervertebral. This disease severely affects the quality-of-life of people. It has been reported that hydroxysafflor yellow A (HSYA), the active ingredient in safflower extract, could inhibit IL-1β-induced apoptosis of endplate chondrocytes. However, the mechanism by which HSYA regulates the occurrence and progression of IDD remains unclear. Methods. Rat endplate chondrocytes were isolated from the intervertebral disc. Next, toluidine blue staining and collagen II immunofluorescence staining were used to identify endplate chondrocytes. Then, MDC staining was used to detect the autophagy of endplate chondrocytes. In addition, Western blot was used to measure the expression of cleaved caspase 3, LC-3I/II and ATG7 in endplate chondrocytes. Results. IL-1β obviously inhibited the viability and proliferation of endplate chondrocytes, while these phenomena were notably reversed by HSYA. Additionally, HSYA was able to inhibit IL-1β-induced apoptosis of endplate chondrocytes. Moreover, HSYA protected endplate chondrocytes against IL-1β-induced inflammation via inducing autophagy. Conclusion. HSYA protected rat endplate chondrocytes against IL-1β-induced injury via promoting autophagy. Therefore, the present study might provide some theoretical basis for exploring novel and effective methods for patients with IDD.
Error Compensation Trajectory Planning Method of Brake Disc Shaft Hole Assembly considering Robot Accumulated Error
Authors: Liu Wei , Ma Yongheng
Published: July 2022

Aiming at the problem of alignment deviation between shaft and hole caused by accumulated error in the assembly process of brake disc shaft hole, a trajectory planning method for compensating accumulated error is proposed. First, the path before the error is planned, and then the second compensation path is planned between the error position and the actual target point, so as to realize the accurate assembly of the brake disc. In this paper, the IRB 1410 robot is taken as the research object, and its kinematic model is established by using the improved D-H parameter method. The joint space quintic B-spline interpolation method was used to carry out trajectory planning, and the improved particle swarm optimization algorithm was introduced to solve the optimization. The optimal time and smooth trajectory were expected to be obtained. Then, using MATLAB software to simulate, compared with the nonoptimized trajectory, not only is the trajectory running time reduced from 8.6 s to 6.7 s but also the maximum joint change angle of each joint is reduced, which proves that the algorithm has optimization effect on trajectory running time and stability. Finally, the accuracy verification experiment of the algorithm is carried out, and the error between simulation and experiment is less than 6%, which shows the effectiveness of the method. This research provides a theoretical basis for improving the responsiveness and stability of brake disc assembly.
Construction of a Prediction Model for College Students’ Psychological Disorders Based on Decision Systems and Improved Neural Networks
Authors: Li Ming , Feng Jiming
Published: July 2022

Modeling and prediction of psychological disorders is a hot topic in current research. Neural networks are very important factors in improving the accuracy and precision ratios of the models which are developed for the prediction of the psychological disorders. An upgraded neural network prediction model of psychological diseases was suggested in order to attain an optimum prediction effect of psychological disorders. First, it analyzes the current progress in predicting the psychological barrier, finds the current limitations of various psychological barrier forecast model, collects the historical data of psychological barriers, and introduces the chaos algorithm of mental disorder history data preprocessing, psychological barriers to better mining change characteristic, and then, after pretreatment using neural network to the psychological barriers to learning history data, introduce the grain subgroup algorithm to improve the problems existing in the neural network, establish a prediction model of the optimal psychological barriers, and finally, through the contrast test and other psychological obstacle prediction model, the results depict enhanced neural network psychological barrier prediction accuracy of more than 95%, compared with the contrast model. Precision is improved by more than 5%. At the same time, the psychological barrier modeling time is shorter, improving the psychological barriers to predict. The efficiency has a higher practical application value.
Ultrasonography-Guided Combination with Elbow Arthrography-Assisted Minimally Invasive Treatment of Radial Neck Fractures in Young Children
Authors: Du Xiangping , Yu Lirong , Wu Xinle , Chen Gan , Xiong Zhigang , Jiang Qiqing
Published: July 2022

Background. A radius neck fracture in children is a common fracture that not only affects the growth and development of children but also has a certain impact on the function of children’s elbow joints. Objective. To probe into the application value of ultrasonography- (US-) guided combination with elbow arthrography in the minimally invasive treatment of radial neck fractures in young children, summarize its clinical effect and provide a minimally invasive, safe, effective, and reliable method for treating radial neck fractures in young children. Methods. Seventy-three patients with type III or IV radial neck fractures were treated from June 2013 to December 2020 and were divided into the Métaizeau group (

n
=
31

, treatment group) and Kirschner wire (

k

-wire)

k

-wire group (

n
=
42

, control group). The Métaizeau group was given US-guided combination with elbow arthrography-assisted modified Métaizeau technique, the

k

-wire group received open reduction and internal fixation with

k

-wire and compared the surgical effect of the two groups. Results. In comparison with the

k

-wire group, time of operation, intraoperative bleeding volume, and hospital stay were signally junior to those in the Métaizeau group (

P
<
0.05

). After surgery, in comparison with the

k

-wire group, the number of degrees to contralateral flexion or forearm rotation was visually lower in the Métaizeau group (

P
<
0.05

), and postoperative complication incidence in the Métaizeau group was visually lower than that in

k

-wire group (

P
<
0.05

). Conclusion. In the minimally invasive treatment of radial neck fractures, US-guided combination with elbow arthrography in young children has better efficacy and high safety. It can be widely promoted and applied clinically.
A Miniaturized Wideband Planar Bow-Tie Slot Antenna with Asymmetric CPW
Authors: Chen Xi , Huang Jiasong , Cheng Chonghu , Liu Leilei
Published: July 2022

In this paper, a novel miniaturized wideband planar bow-tie slot antenna is proposed. For the purpose of miniaturization and wide bandwidth, the effects of the dimension and shape of the bow-tie slot and feed structure are analyzed. This antenna adopts a water droplet slot, fed by an optimized asymmetric coplanar waveguide (CPW). By adjusting the feeding line, the impedance characteristic of the antenna is greatly improved that leads to a broader bandwidth. The proposed antenna operates from 2.8 GHz to 5.25 GHz with a gain of 3.8 dB. Compared with the traditional triangle bow-tie antenna, the relative bandwidth of the proposed antenna is broadened to more than 61%, while the size is reduced by about 36%, which indicates the proposed antenna is suitable for a variety of wireless applications.
Optimization of Multimodal Japanese Teaching Model Using Virtual Reality
Authors: Ye Xiuhua
Published: July 2022

The potential of virtual reality technology to aid education is well acknowledged. It has already been implemented in at least 20 public schools and institutions, with many more participating in assessment and research initiatives. The proposed methodology is to use virtual reality technology in Japanese teaching in order to create an immersive virtual teaching environment for the learners. They can see and hear Japanese teaching through visual, auditory, tactile, and other senses. They can also interact through virtual reality. The objects simulated by this technology interact with each other, thus creating a feeling of living in a super world. The products of virtual reality technology can be used as a new tool for learning the Japanese language. On the one hand, the advantages of virtual reality technology are assisting Japanese teaching and training due to its immersive, interactive, and systematic characteristics. On the other hand, we can use multimodal data fusion to make the data sources more diversified and optimize the Japanese teaching model through virtual reality technology. In addition, more effective and interesting teaching methods provide references for others. The experimental results show that our multimodal fusion BP (backpropagation) neural network algorithm provides a better result than the single decision tree algorithm and support vector machine algorithm.
LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer
Authors: Meng Min , Wu Yi-chen
Published: July 2022

Prostate cancer (PCa) is the most common cancer affecting men, with increasing global mortality and morbidity rates. Despite the progress in the diagnosis and treatment of PCa, patient outcomes remain poor, and novel therapeutic targets for PCa are urgently needed. Recently, circular RNAs (circRNAs) have been studied in-depth as potential biomarkers for many diseases. In this study, circRNA microarrays using four pairs of PCa tissues were utilized to show that circGFRA1 was upregulated in PCa tumor tissues. CircGFRA1 is suggested to play an oncogene role in PCa progression as the silencing of circGFRA1 inhibited the proliferation, migration, and immune escape activity of PCa cells. Furthermore, by utilizing bioinformatics analysis, RIP, RNA pull-down, and luciferase reporter assays, our results showed that LMX1B could bind to the GFRA1 promoter and regulate circGFRA1 expression in PCa cells and circGFRA1 upregulated HECTD1 expression through sponging miR-3064-5p. This novel LMX1B/circGFRA1/miR-3064-5p/HECTD1 axis identified in PCa provides new insights for developing novel therapeutic strategies for PCa.
[Retracted] Research on the Protection of Extensor and Flexor Muscles in the Waist and Back of Competitive Athletes
Authors: Yu Xuedou , Ma Ligang , He Ruihua , Zhao Jian , Wang Shanshan
Published: July 2022

In the past, in the study of special sports quality of heavy antagonistic sports events, the study of strength quality training was emphasized. The transformation of athletes’ strength quality to special strength was highlighted, and the special exercises which tended to be consistent with the characteristics of wrestling events were added. However, in competition and training, athletes’ spine bears a heavy load. Long‐term static contraction of lumbar muscles can lead to excessive local load and injury of lumbar muscles. In this paper, the test results of athletes’ joints are analyzed, and the waist protection scheme for athletes’ strength training is obtained. First of all, solve the problem of athletes’ action mode and improve athletes’ muscle endurance. All special sports quality evaluation can reach a good level. Then, enhance athletes’ explosive power. Thus, all special sports quality evaluations can reach an excellent level. It is concluded that the waist and back are the key parts to support their participation in various sports, maintain body balance, and realize power transmission. Through the study, it is found that there are significant differences in the muscle strength indexes of the maximum strength of the waist and back of athletes of different levels, which fully proves the characteristics of the maximum strength of the waist and back. Through the test, we can understand the flexion and extension strength, range, speed, force, and flexion and extension ratio of athletes’ joints and take timely optimization measures according to the test results to avoid sports injuries in training. It has a key guiding significance for the measurement, analysis, and evaluation of athletes’ joint muscle strength, as well as rehabilitation training after injury and prevention of reinjury.
r
-Hyperideals and Generalizations of
r
-Hyperideals in Krasner Hyperrings
Authors: Xu Peng , Bolat Melis , Kaya Elif , Onar Serkan , Ersoy Bayram Ali , Hila Kostaq
Published: July 2022

This paper deals with Krasner hyperrings as an important class of algebraic hyperstructures. We investigate some properties of

r

-hyperideals in commutative Krasner hyperrings. Some properties of

p
r

-hyperideals are also studied. The relation between prime hyperideals and

r

-hyperideals is investigated. We show that the image and the inverse image of an

r

-hyperideal are also an

r

-hyperideal. We also introduce a generalization of

r

-hyperideals, and we prove some properties of them.
Intelligent Analysis of Logistics Information Based on Dynamic Network Data
Authors: Yang Pengbo
Published: July 2022

In order to realize the intellectualization of logistics information analysis, this paper proposes an intelligent analysis method of logistics information based on dynamic network data cloud mining. This paper selects the data of a shipping logistics platform to realize the intelligent analysis experiment of logistics information based on cloud clustering mining. The purpose of the experiment is to find out the advantages of logistics information intelligent analysis based on cloud mining by comparing the performance differences between cloud clustering mining and traditional clustering mining in logistics information intelligent analysis. This paper builds an experimental environment based on Hadoop and MapReduce parallelization based on K-means algorithm. Taking the obtained logistics data as the analysis object, preprocess it and get the results based on cloud clustering mining. The experimental results show that the parallel mining analysis method is 179.2% slower than the traditional mining analysis method in dataset data1, 60.4% slower in dataset data2, and 2.8% faster in dataset data1. The intelligent analysis method of logistics information based on cloud clustering mining has good scalability and speedup ratio. Conclusion. Applying cloud mining to logistics information analysis and realizing the intelligent analysis of logistics information has great advantages, and can well meet the content and efficiency needs of logistics information analysis stakeholders.
Periplocin Induces Apoptosis of Pancreatic Cancer Cells through Autophagy via the AMPK/mTOR Pathway
Authors: Zhang Hewei , Wang Yongqiang , Zhang Yan , Zheng Beishi , Wang Xiaowu , Chen Jiawei , Chen Bicheng , Xie Gangyin , Yang Lihong
Published: July 2022

Periplocin, a natural compound, has been shown to induce apoptosis in a variety of cancer cells. However, no research has been conducted to demonstrate that Periplocin has a regulatory effect on autophagy. This study is aimed to determine the effect of Periplocin treatment on autophagy in human pancreatic cancer cells, as well as the underlying mechanisms. Pancreatic cancer cells were treated with different concentrations of Periplocin, and real-time cell analysis (RTCA), colony formation assay, and Ki67 immunofluorescence detection were used to determine cell proliferation. Autophagy protein was detected by immunofluorescence and western blotting. Western blotting was also used to detect the caspase family of apoptotic proteins. Flow cytometry and TUNEL staining were used to detect cell apoptosis. Following treatment with Periplocin, the expression of autophagy genes was detected using RNA-seq. In vivo examination of the effect of Periplocin on autophagy in pancreatic was performed using a xenograft model. Periplocin inhibits the proliferation of CFPAC1 and PANC1 cells and induces autophagy by regulating the AMPK/mTOR pathway. Using the AMPK inhibitor Compound C(CC), both the Periplocin-induced inhibition of cell proliferation and autophagy activation was reduced, which further verified this conclusion. Periplocin inhibits CFPAC1 xenograft tumor growth in nude mice and increases tumor cell autophagy. Collectively, these results have shown that Periplocin promotes autophagy in human pancreatic cancer cells by regulating the AMPK/mTOR pathway.
The Reality of Using Virtual Labs in Teaching Advanced Biology Curricula in Developing Higher-Order Thinking Skills (HOTS) among Female Teachers at Secondary Level in Al-Kharj
Authors: Abdulrahman Nami Alshaikh Asma
Published: July 2022

Over the last few years, the use of the web and virtual technologies in school education has become widespread. This study aimed at identifying the reality of using virtual laboratories (VLs) in teaching advanced biology curricula in developing higher-order thinking skills (HOTS) among female students at the secondary level in Al-Kharj district, Saudi Arabia. The study adopted descriptive methodology. Fifty-four biology female teachers at the secondary level in Al-Kharj completed a questionnaire consisting of four dimensions: the awareness of the virtual laboratories’ importance in developing higher-order thinking skills, the use of virtual laboratories in developing higher-order thinking skills, obstacles to using virtual laboratories in teaching advanced biology curricula, and the requirements for using virtual laboratories in teaching advanced biology curricula to develop higher-order thinking skills. The results showed the awareness of the VLs’ importance in developing higher-order thinking skills achieved with a large degree, using VLs with a middle degree, the impediments of using VLs in developing higher-order thinking skills with a large degree, and the requirements for using VLs in teaching biology for developing higher-order thinking skills with a very large degree. The results also showed statistically significant differences between the responses of the female teachers according to the number of training workshops in VLs. There were no statistically significant differences with regard to the academic degree and the years of experience. The study recommended a reconsideration of technological infrastructure in schools where VLs are used in teaching and learning.
Removal of Hexavalent Chromium from Aqueous Solutions Using Natural Zeolite Coated with Magnetic Nanoparticles: Optimization, Kinetics, and Equilibrium Studies
Authors: Asanu Mohammed , Beyene Dejene , Befekadu Adisu
Published: July 2022

Stringent discharge limits, high costs, and low removal efficiency of the conventional treatment methods are facing challenges to handle industrial effluents containing heavy metals. The objective of this study was to use a recoverable magnetic zeolite to remove Cr(VI) from aqueous solution. The study investigated the application of nanotechnology to improve surface properties, recoverability, and adsorptive capacity of natural zeolite and the CCD-RSM-based optimization of adsorption process variables. Natural zeolites coated with various fractions of magnetic nanoparticles (25%, 33.33%, 50%, and 75%) were investigated for surface characters, adsorption capacity, removal efficiency, and recoverability. Natural zeolite coated with 33.33% (MZ33) was found a better adsorbent in terms of surface characters, adsorption capacity, and removal efficiency. Thirty batch adsorption experiments designed with CCD were carried out in order to optimize adsorption process variables using response surface methodology (RSM). It was found that [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text] were the optimum conditions to achieve 93.57% Cr(VI) removal, which is very close to the experimental result of 94.88%. The adsorption isotherm determined from the operating parameters revealed that experimental data fit to the Langmuir isotherm model with [Formula: see text] and [Formula: see text]. This proved that the adsorption of Cr(VI) on magnetic zeolite involved monolayer adsorption on the active sites. The separation factor, [Formula: see text], value lies between 0 and 1 indicating that adsorption of Cr(VI) on the magnetic zeolite is favorable. The adsorption kinetics study follows pseudo-first order in the removal of Cr(VI). FTIR analysis of magnetic zeolite revealed the presence of numerous functional groups participating in Cr(VI) adsorption. The current study confirmed that magnetic zeolite is a cost-effective and favorable material for the removal of Cr(VI) from aqueous solution.
Dry Needling Produces Mild Injuries Irrespective to Muscle Stiffness and Tension in Ex Vivo Mice Muscles
Authors: Bosque Marc , Margalef Ramon , Carvajal Oscar , Álvarez David , Santafe Manel M.
Published: July 2022

Numerous studies have suggested that the myofascial trigger points are responsible for most of the myofascial pain syndrome, so it seems reasonable that its destruction is a good therapeutic solution. The effectiveness of dry needling (DN) has been confirmed in muscles with myofascial trigger points, hypertonicity, and spasticity. The objective of this study is to analyze the need of repetitive punctures on muscles in different situations. The levator auris longus (LAL) muscle and gastrocnemius muscle from adult male Swiss mice were dissected and maintained alive, while being submerged in an oxygenated Ringer’s solution. DN was evaluated under four animal models, mimicking the human condition: normal healthy muscles, muscle fibers with contraction knots, muscles submerged in a depolarizing Ringer solution (KCl-CaCl2), and muscles submerged in Ringer solution with formalin. Thereafter, samples were evaluated with optical microscopy (LAL) and scanning electron microscopy (gastrocnemius). Healthy muscles allowed the penetration of needles between fibers with minimal injuries. In muscles with contraction knots, the needle separated many muscle fibers, and several others were injured, while blood vessels and intramuscular nerves were mostly not injured. Muscles submerged in a depolarizing solution inducing sustained contraction showed more injured muscular fibers and several muscle fibers separated by the needle. Finally, the muscles submerged in Ringer solution with formalin showed a few number of injured muscular fibers and abundant muscle fibers separated by the needle. Scanning electron microscopy images confirm the optical analyses. In summary, dry needling is a technique that causes mild injury irrespective of the muscle tone.