bluuebunny/crossref_metadata_2025 huggingface dataset:
Whole-Body Vibration to Treat Low Back Pain: Fact or Fad?
Authors: Perraton Luke , Machotka Zuzana , Kumar Saravana
Published: September 2010

Purpose: The purpose of this systematic review was to evaluate the current evidence base for whole-body vibration as a treatment for low back pain (LBP).

Summary of key points: Whole-body vibration through occupational exposure has previously been recognized as an aetiological factor in LBP. Previous studies have identified whole-body vibration (WBV) as a cause of LBP in various sitting-based occupations that involve machinery and repetitive vibration. In the last decade, however, WBV has been advocated as a safe and effective treatment for LBP. Despite the growing popularity of WBV in clinical practice, this systematic review of the literature identified only two studies that investigated the effectiveness of WBV as a treatment option for LBP, and an assessment of the quality of these studies demonstrated several methodological problems that may have biased their findings. While there is emerging evidence for the effectiveness of WBV in treating some medical conditions, the evidence for WBV as a treatment for LBP remains equivocal.

Recommendations: Based on the current body of evidence, routine use of WBV to treat LBP should be undertaken with caution. Further rigorous research designed to investigate the effectiveness of WBV as a safe and high-quality treatment for LBP is required.
Ex Post Evaluation of Calibrated Simulation Models of Significantly Different Future Systems
Authors: Iyer Shrisan , Ozbay Kaan , Bartin Bekir
Published: September 2010

The calibration and validation of traffic simulation models are critical procedures in ensuring that developed models accurately represent real-world conditions. When planned future systems are simulated, validation is not possible because field data cannot be collected for a system that has not yet been built. Instead, modelers have no choice but to follow standard calibration procedures and, in the absence of validating data, accept a model that appears to function correctly. Ex post evaluation of traffic simulation models is a neglected, yet valuable, area of research because it offers modelers a chance to validate their future system simulations with field data. The calibration assumptions used by modelers of future systems are investigated by checking whether improvised calibrations hold up to ex post evaluation. A case study directed at measuring the changes to user behavior in an existing and a reconstructed traffic system is presented. In addition, the benefits of ex post evaluation and methods to improve the calibration and validation of future models are discussed.
La parole épuise-t-elle le sens ?
Authors: Nakajima Takahiro
Published: September 2010

Pour dominer le langage, la philosophie chinoise a découvert des moyens autres que la « rectification des noms ». Il s’agit d’une part de l’annihilation totale de la langue, et d’autre part d’une clarification de la langue plus grande que celle opérée par la « rectification de la langue ». Pour mieux comprendre cette situation, il est nécessaire à remonter la généalogie à partir de la controverse sur la théorie de « la parole épuise le sens » et celle de « la parole n’épuise pas le sens » qui se déroula à l’époque des six dynasties (deuxième moitié du IIIème siècle de l’ère chrétienne). On réfléchit la controverse entre le discours d’Ouyang Jian et celui de Xun Can. Puis, on arrive à la théorie de Wang Bi qui synthétise la controverse et invente l’autre idée sur le langage. Cette idée est un « langage oublié » qui essaie d’annihiler complètement l’altérité du langage. Ce qu’on vise par l’annihilation du langage, c’est un monde du sens pur, qui augmente le profit, qui est gouverné magnifiquement, c’est un monde où tout est ramené à l’Un.
Caracterización térmica de placas de yeso con material de cambio de fase incorporado
Authors: Oliver A. , Neila F. J. , García A.
Published: September 2010

En este trabajo se demuestra la idoneidad de incorporar materiales de cambio de fase en placas de yeso para incrementar su capacidad de almacenamiento térmico. Para ello se evalúa y se compara la capacidad de almacenamiento térmico, de diferentes elementos constructivos cuyo uso y aplicación es similar a la de las placas de yeso: trasdosado y tabique separador. Se ha disenado y puesto en funcionamiento una instalación experimental que simula las condiciones de contorno que se producen en una estancia donde estén instalados los diferentes materiales y sistemas constructivos. Se ha estudiado la influencia de diferentes para´metros y variables del sistema (temperatura de trabajo, velocidad del aire, presentación de los materiales de cambio de fase, ubicación en el edificio,…), para constituir un sistema de almacenamiento de calor latente, que, complementado con estrategias pasivas (captación solar, ventilación natural), reduzca las necesidades de consumo energético para la climatización de edificios. Se obtiene que las placas de yeso con un 45% en peso de material de cambio de fase es capaz de almacenar en 1,5 cm de espesor, 5 veces la energía térmica de un panel de yeso laminado con el mismo espesor, y la misma cantidad que 1/2 pie de fábrica ladrillo hueco sencillo, en el rango de temperaturas próximas a la de confort (20-30 ºC), manteniendo las propiedades físicas y mecánicas exigidas en la normativa.
Monitorización de variables medioambientales y energéticas en la construcción de viviendas protegidas: Edificio Cros-Pirotecnia en Sevilla
Authors: León A. L. , Muñoz S. , León J. , Bustamante P.
Published: September 2010

Este trabajo forma parte del proyecto de investigación Efficacia: Reducción del consumo energético y del impacto ambiental en la construcción de viviendas protegidas en Andalucía. Dicho proyecto tiene como objeto de estudio el edificio de viviendas protegidas de Cros-Pirotecnia, emplazado en el Barrio “Pirotecnia” del Distrito Sur de la ciudad de Sevilla. Uno de los objetivos de este trabajo es conocer la demanda y consumo energético, en tiempo real, de este conjunto de viviendas en régimen de alquiler. Para tener en cuenta la influencia de sus habitantes, los resultados obtenidos mediante la instalación de monitorización se ha complementado con una serie de encuestas sobre los hábitos de consumos de sus inquilinos. En este artículo se describe la metodología empleada para la monitorización y se presentan los principales resultados obtenidos, una vez transcurridos doce meses desde el comienzo del período de medida. Asimismo, se ofrecen los resultados más significativos de las encuestas realizadas a los inquilinos.
La técnica DInSAR: bases y aplicación a la medición de subsidencias del terreno en la construcción
Authors: Sillerico E. , Marchamalo M. , Rejas J. G. , Martínez R.
Published: September 2010

Las subsidencias se definen como movimientos lentos y paulatinos de la superficie del terreno natural o construido y que pueden afectar a todo tipo de terrenos. Son debidos a cambios tensionales inducidos en éstos, por: descenso del nivel freático (extracción en acuíferos), minería subterránea (minerales, carbón, sal), excavación de túneles, extracción de petróleo o gas, procesos de disolución y lavado de materiales, consolidación de suelos blandos y orgánicos, etc. El control de subsidencias del terreno es esencial en fase constructiva y de monitorización de obras, ya que como se producen de manera progresiva, pueden ser reconocidas antes de que causen danos a la infraestructura. Los procedimientos más habituales para monitorizar subsidencias en obras de ingeniería son la topografía de precisión (nivelación), inclinómetros, fotogrametría, láser escáner y DGPS (Sistema de Posicionamiento Global Diferencial). En la última década se han realizado experiencias con una nueva técnica de medida de subsidencias en la superficie del terreno, a partir de imágenes adquiridas desde satélite por sensores activos en la región de las microondas, denominada DInSAR (Interferometría Diferencial con Radar de Apertura Sintética), y se fundamenta en la detección de pequenas variaciones de altitud a partir del cálculo de la diferencia de fase de pares de imágenes radar sobre un mismo área de estudio. En este artículo se presenta la evolución de DInSAR, su aplicación a distintos campos con resultados satisfactorios y se expone una revisión sobre su utilización para monitorizar y medir subsidencias en estructuras de tierra en el sector de la Construcción y en los campos de la Geotecnia, Hidrogeología y Vulcanología.
Félix Candela. En memoria (1910-1997). Del cascarón de hormigón a las estructuras ligeras del s. XXI
Authors: Cassinello P. , Schlaich M. , Torroja J. A.
Published: September 2010

El 27 de enero de 2010 se cumplió el centenario del nacimiento de célebre arquitecto de origen español Félix Candela, uno de los más destacados protagonistas de la Aventura Laminar de la Arquitectura Moderna. Su fama internacional la adquirió a través de la construcción de más de 800 cascarones de hormigón armado dotados, no sólo de una racional y óptima forma resistente, sino también de una impactante y escultural belleza. No en vano, Frei Otto, Ove Arup y David Billington han descrito su obra como un “Arte Estructural”.
Al hilo del análisis de las aportaciones realizadas por Félix Candela, el presente artículo analiza también nuevas estructuras ligeras, como continuidad histórica de esa racional búsqueda de la optimización de la forma resistente con diferentes materiales y tecnologías. Evolución y destino contemplado por la Internacional Association for Structural Shells IASS, fundada por Eduardo Torroja en 1959 y que hoy continúa en plena actividad.
Prolactin-Induced Production of Reactive Oxygen Species and IL-1β in Leukocytes from the Bony Fish Gilthead Seabream Involves Jak/Stat and NF-κB Signaling Pathways
Authors: Olavarría Víctor H. , Sepulcre María P. , Figueroa Jaime E. , Mulero Victoriano
Published: September 2010

Prolactin (PRL), a peptide hormone produced by the pituitary gland, was shown to play an important role in the modulation of the immune system of lower and higher vertebrates. To further investigate the effects of PRL on the activation of professional phagocytes of bony fish, we stimulated head kidney leukocytes and purified macrophages from the gilthead seabream (Sparus aurata L.) with various physiological concentrations of native salmon PRL for 2 and 16 h and analyzed the respiratory burst activity and proinflammatory cytokine expression profile. The results showed that PRL was able to induce the production of reactive oxygen species and the expression of IL-1β and TNF-α in a similar way to two major pathogen-associated molecular patterns: polyinosinic–polycytidylic acid and genomic DNA from the bacterium Vibrio anguillarum. Interestingly, when the leukocytes were stimulated with suboptimal concentrations of PRL in the presence of bacterial DNA, the expression of IL-1β was synergistically induced. More importantly, all PRL activities were blocked by neutralizing Abs to PRL, as well as by pharmacological inhibitors of the Jak/Stat and NF-κB signaling pathways. In addition, EMSA and HPLC/mass spectrometry further confirmed that Stat and NF-κB were involved in the activation of seabream leukocytes by PRL. Collectively, our data identified PRL as a key regulator of the activation of fish professional phagocytes and demonstrated a cross-talk between TLR/NF-κB and PRLR/Jak/Stat signaling pathways. In addition, to the best of our knowledge, this is the first report showing that PRL modulates the activation of phagocyte NADPH oxidase through the Jak/Stat pathway in vertebrates.
Mechanisms Regulating Monocyte CXCL8 Secretion in Neurocysticercosis and the Effect of Antiparasitic Therapy
Authors: Uddin Jasim , Gonzalez Armando E. , Gilman Robert H. , Thomas Lynette H. , Rodriguez Silvia , Evans Carlton A. W. , Remick Daniel G. , Garcia Hector H. , Friedland Jon S.
Published: September 2010

Neurocysticercosis (NCC) due to infection with Taenia solium is a major cause of epilepsy worldwide. Larval degeneration, which may follow antiparasitic treatment, results in clinical symptoms due to inflammatory cell influx. Mechanisms regulating this are not well understood, but chemokines have a key role. Stimulation of human monocytes by cyst Ags from NCC-infected pigs showed that scolex and membrane Ags drive CXCL8 and CCL2 secretion. Antiparasitic treatment of pigs increased CXCL8 in response to brain, but not muscle, cyst Ags. Cyst-fluid Ags did not elicit monocyte chemokine secretion, inhibited LPS-induced CXCL8 by up to 89%, but did not alter CCL2 secretion. This effect was inhibited by anti–IL-10 Abs. Plasma CXCL8, TNF-α, IL-10, eotaxin, IL-1, IL-1ra, soluble IL-1R-II, and soluble TNFR-I and -II levels were evaluated in 167 NCC patients. Patients had lower plasma CXCL8 and TNF-α concentrations than control subjects. In summary, larval Ags from brain and muscle cysts differentially regulate chemokine secretion. Cyst-fluid inhibits CXCL8, and this is blocked by anti–IL-10 Abs. CXCL8 concentrations are decreased in patient plasma. Following anti-parasitic therapy, scolex and membrane Ags are exposed, and cyst fluid is decreased, leading to inflammatory cell influx. Taken together, the cellular, porcine, and human data may explain, in part, why NCC is usually asymptomatic but may cause proinflammatory symptoms, particularly following treatment.
Factor H Facilitates Adherence of Neisseria gonorrhoeae to Complement Receptor 3 on Eukaryotic Cells
Authors: Agarwal Sarika , Ram Sanjay , Ngampasutadol Jutamas , Gulati Sunita , Zipfel Peter F. , Rice Peter A.
Published: September 2010

Neisseria gonorrhoeae can engage human complement receptor 3 (CR3) directly or through surface-bound iC3b. Factor H (fH) that binds to bacteria facilitates conversion of C3b to iC3b. fH also binds directly to CR3 on professional phagocytes. Certain nonprofessional phagocytes, such as primary cervical epithelial cells, also express CR3. We hypothesized that fH could bridge bacteria to CR3 and facilitate gonococcal association with host cells. Specificity of the fH–CR3 interaction was confirmed using human CR3-transfected Chinese hamster ovary (CHO-CR3) cells. Using recombinant proteins that comprised contiguous fH domains (fH contains 20 short consensus repeat [SCR] domains) fused to murine Fc, we observed strong binding through SCRs 18–20, whereas weaker binding occurred through SCRs 6–10. Both regions also bound to unsialylated porin (Por) B.1A-expressing N. gonorrhoeae. Accordingly, fH-related protein 1 (three of its five SCRs are highly homologous to fH SCRs 18–20) bound to CHO-CR3 and to unsialylated PorB.1A gonococci. An alternatively spliced variant of fH called fH-like protein-1 (contains fH SCRs 1–7) bound to gonococci but minimally to CHO-CR3. An fH SCRs 6–20 construct enhanced binding of unsialylated PorB.1A gonococci to CHO-CR3. However, a construct that contained only the apparently relevant SCRs (6, 7, and 18–20) bound to CHO-CR3 and to gonococci separately, but did not enhance bacteria–CR3 interactions, suggesting that the intervening SCRs (8–17) may impart a configurational and spatial requirement for fH to bridge gonococci to CR3. These results indicate adherence between fH-coated gonococci and CR3 and may provide a means for gonococci to gain sanctuary into nonprofessional phagocytes.
Leishmania donovani Promastigotes Evade the Antimicrobial Activity of Neutrophil Extracellular Traps
Authors: Gabriel Christelle , McMaster W. Robert , Girard Denis , Descoteaux Albert
Published: September 2010

Upon their recruitment to a site of infection and their subsequent activation, neutrophils release DNA and a subset of their granule content to form filamentous structures, known as neutrophil extracellular traps, which capture and kill microorganisms. In this study, we show that Leishmania promastigotes induced the rapid release of neutrophil extracellular traps from human neutrophils and were trapped by these structures. The use of Leishmania mutants defective in the biosynthesis of either lipophosphoglycan or GP63 revealed that these two major surface promastigote virulence determinants were not responsible for inducing the release of the surface protease neutrophil extracellular traps. We also demonstrate that this induction was independent of superoxide production by neutrophils. Finally, in contrast to wild-type Leishmania donovani promastigotes, mutants defective in lipophosphoglycan biosynthesis were highly susceptible to the antimicrobial activity of neutrophil extracellular traps. Altogether, our data suggest that neutrophil extracellular traps may contribute to the containment of L. donovani promastigotes at the site of inoculation, thereby facilitating their uptake by mononuclear phagocytes.
Vitamin D3 Upregulated Protein 1 Suppresses TNF-α–Induced NF-κB Activation in Hepatocarcinogenesis
Authors: Kwon Hyo-Jung , Won Young-Suk , Suh Hyun-Woo , Jeon Jun-Ho , Shao Yan , Yoon Suk-Ran , Chung Jin-Woong , Kim Tae-Don , Kim Hwan-Mook , Nam Ki-Hoan , Yoon Won-Kee , Kim Dae-Ghon , Kim Jeong-Hwan , Kim Young-Sung , Kim Dae-Yong , Kim Hyoung-Chin , Choi Inpyo
Published: September 2010

Vitamin D3 upregulated protein 1 (VDUP1) is a candidate tumor suppressor, the expression of which is dramatically reduced in various tumor tissues. In this study, we found that VDUP1 expression is suppressed during human hepatic carcinogenesis, and mice lacking VDUP1 are much more susceptible to diethylnitrosamine-induced hepatocarcinogenesis compared with wild type mice. VDUP1-deficient tumors proliferated significantly more than wild type tumors and had corresponding changes in the expression of key cell cycle regulatory proteins. In addition, the hepatomitogen-induced response was associated with a considerable increase in the release of TNF-α and subsequent enhancement of NF-κB activation in VDUP1-deficient mice. When cells were treated with TNF-α, the VDUP1 level was markedly reduced, concomitant with elevated NF-κB activation. Furthermore, the overexpression of VDUP1 resulted in the robust suppression of TNF-α–activated NF-κB activity via association with HDAC1 and HDAC3. These results indicate that VDUP1 negatively regulates hepatocarcinogenesis by suppressing TNF-α–induced NF-κB activation.
HIV-1 Nef Disrupts Maturation of CD4+ T Cells through CD4/Lck Modulation
Authors: Chrobak Pavel , Simard Marie-Chantal , Bouchard Nathalie , Ndolo Thomas Mutushi , Guertin Joël , Hanna Zaher , Dave Vibhuti , Jolicoeur Paul
Published: September 2010

The HIV-1 Nef protein is a major determinant of HIV-1 pathogenicity. It has been found to induce thymocyte depletion, but the mechanisms involved are not completely understood. Also, nothing is known about its effects on thymocyte selection. We used the CD4C/HIVNef transgenic (Tg) mice, which develop a profound CD4+ T cell lymphopenia, to study their thymic development. We report that HIV-1 Nef causes depletion of double-positive thymocytes and impairs selection and lineage commitment of CD4+ single-positive thymocytes. This latter defect could be relieved by increasing the affinity of the TCR–MHC interaction or by allowing CD4+ T cell maturation to proceed in absence of the CD4 tail, in double-Tg (Nef × CD4tailless) mice or in the presence of constitutively active Tg LckY505F. These rescue strategies also resulted in reversal of peripheral CD4+ T cell lymphopenia. Our data indicate that impairment of Lck-mediated CD4 coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis.
Kac's Theorem for weighted projective lines
Authors: Crawley-Boevey William
Published: September 2010

We prove an analogue of Kac’s Theorem, describing the dimension types of indecomposable coherent sheaves (or parabolic bundles) over weighted projective lines in terms of root systems for loop algebras of Kac–Moody Lie algebras. We use a theorem of Peng and Xiao to associate a Lie algebra to the category of coherent sheaves for a weighted projective line over a finite field, and find elements of this Lie algebra which satisfy the relations defining the loop algebra. We use these elements in the proof of our analogue of Kac’s Theorem.
Noncommutative del Pezzo surfaces and Calabi-Yau algebras
Authors: Etingof Pavel , Ginzburg Victor
Published: September 2010

The hypersurface in

\mathbb C^3

with an isolated quasi-homogeneous elliptic singularity of type

\tilde E_r

,

r= 6, 7, 8

, has a natural Poisson structure. We show that the family of del Pezzo surfaces of the corresponding type

E_r

provides a semiuniversal Poisson deformation of that Poisson structure.

We also construct a deformation-quantization of the coordinate ring of such a del Pezzo surface. To this end, we ﬁrst deform the polynomial algebra

\mathcal C [x_1, x_2, x_3]

to a noncommutative algebra with generators

x_1, x_2, x_3

and the following 3 relations labelled by cyclic parmutations

(i, j, k)

of

(1, 2, 3)

:

x_i x_j − t \cdot x_i x_j = \Phi_k (x_k), \quad \Phi_k \in \mathbb C[x_k].

This gives a family of Calabi-Yau algebras

\mathfrak A^t(\Phi)

parametrized by a complex number

t \in \mathbb C^\times

and a triple

\Phi = (\Phi_1, \Phi_2, \Phi_3)

of polynomials of speciﬁcally chosen degrees. Our quantization of the coordinate ring of a del Pezzo surface is provided by noncommutative algebras of the form

\mathfrak A^t(\Phi)/ 《 \Psi》

, where

《\Psi》 \subset \mathfrak A^t(\Phi)

stands for the ideal generated by a central element Ψ which generates the center of the algebra

\mathfrak A^t(\Phi)

if

\Phi

is generic enough.
Ricci flow compactness via pseudolocality, and flows with incomplete initial metrics
Authors: Topping Peter
Published: September 2010

By exploiting Perelman’s pseudolocality theorem, we prove a new compactness theorem for Ricci flows. By optimising the theory in the two-dimensional case, and invoking the theory of quasiconformal maps, we establish a new existence theorem which generates a Ricci flow starting at an arbitrary incomplete metric, with Gauss curvature bounded above, on an arbitrary surface. The criterion we assert for well-posedness is that the flow should be complete for all positive times; our discussion of uniqueness also invokes pseudolocality.
Labeled floor diagrams for plane curves
Authors: Fomin Sergey , Mikhalkin Grigory
Published: September 2010

Floor diagrams are a class of weighted oriented graphs introduced by E. Brugallé and the second author. Tropical geometry arguments lead to combinatorial descriptions of (ordinary and relative) Gromov–Witten invariants of projective spaces in terms of floor diagrams and their generalizations. In a number of cases, these descriptions can be used to obtain explicit (direct or recursive) formulas for the corresponding enumerative invariants. In particular, we use this approach to enumerate rational curves of given degree passing through a collection of points on the complex plane and having maximal tangency to a given line. Another application of the combinatorial approach is a proof of a conjecture by P. Di Francesco–C. Itzykson and L. Göttsche that in the case of a fixed cogenus, the number of plane curves of degree
d
passing through suitably many generic points is given by a polynomial in
d
, assuming that
d
is sufficiently large. Furthermore, the proof provides a method for computing these “node polynomials”. A
labeled floor diagram
is obtained by labeling the vertices of a floor diagram by the integers 1; . . . ;
d
in a manner compatible with the orientation.We show that labeled floor diagrams of genus 0 are equinumerous to labeled trees, and therefore counted by the celebrated Cayley formula. The corresponding bijections lead to interpretations of the Kontsevich numbers (the genus-0 Gromov– Witten invariants of the projective plane) in terms of certain statistics on trees.
TALDICE-1 age scale of the Talos Dome deep ice core, East Antarctica
Authors: Buiron D. , Chappellaz J. , Stenni B. , Frezzotti M. , Baumgartner M. , Capron E. , Landais A. , Lemieux-Dudon B. , Masson-Delmotte V. , Montagnat M. , Parrenin F. , Schilt A.
Published: September 2010

Abstract. A new deep ice core drilling, TALDICE, has been successfully handled by a European team at Talos Dome, in the Ross Sea sector of East Antarctica, down to 1620 m depth. Using stratigraphic markers and a new inverse method, we produce the first official chronology of the ice core, called TALDICE-1. We show that it notably improves an a priori chronology resulting from a one-dimensional ice flow model, and that it is in agreement with a posteriori controls of the resulting accumulation rate and thinning function along the core. An absolute uncertainty of only 300 yr is obtained in the course of the last deglaciation. This uncertainty remains lower than 600 yr over Marine Isotope Stage 3, back to 50 kyr BP. The phasing of the TALDICE ice core climate record with respect to the central East Antarctic plateau and Greenland records can thus be determined with a precision allowing for a discussion of the mechanisms at work at sub-millennial time scales.
Magnetic and Acoustically Active Lipospheres for Magnetically Targeted Nucleic Acid Delivery
Authors: Vlaskou Dialechti , Mykhaylyk Olga , Krötz Florian , Hellwig Nicole , Renner Ritta , Schillinger Ulrike , Gleich Bernhard , Heidsieck Alexandra , Schmitz Georg , Hensel Karin , Plank Christian
Published: September 2010

With the aim of obtaining a carrier for combined magnetic‐field‐ and ultrasound‐targeted nucleic acid delivery, acoustically active lipospheres are prepared that comprise magnetic nanoparticles and plasmid DNA or synthetic siRNA. The lipospheres, with average diameters of 5 μm and smaller, are obtained upon shaking a mixture of soybean oil, a cationic lipid, magnetic nanoparticles, a nucleic acid, and aqueous buffer in a perfluoropropane atmosphere in a sealed vial. These lipospheres create contrast in ultrasound imaging and display greatly increased magnetophoretic mobility and in consequence greatly improved magnetic retention in a flow model when compared with free magnetic nanoparticles. In cell culture, the lipospheres are sedimented within minutes to the surface of cells using a gradient magnetic field. This sedimentation results in the association of about 50% of the applied plasmid DNA with the cells and in functional DNA and siRNA delivery in vitro. Under these conditions, ultrasound does not have an enhancing effect on nucleic acid delivery. When magnetic, acoustically active lipospheres carrying 125iodine‐labeled plasmid DNA are injected into the tail veins of mice, the application of a gradient magnetic field to the chests of the mice results in a two‐ to threefold enrichment of both lung lobes with the plasmid. A similar enrichment is obtained when ultrasound alone (1 MHz, 10 min) is applied. The combined application of magnetic field and ultrasound has no synergistic effect in terms of liposphere capture in the lungs. Histological analysis reveals intact lipospheres in lung capillaries. A synergistic effect of magnetic field and ultrasound is observed in site‐specific plasmid deposition in a dorsal skinfold chamber model in mice after injection into the carotis. These conditions also result in functional plasmid delivery to the vasculature after intrajugular injection.
Original and Efficient Synthesis of D‐Cycloserine
Authors: Li Xiaomeng , Meng Xia , Duan Hongdong , Wang Lizhen , Wang Shixiao , Zhang Yi , Qin Dawei
Published: September 2010

A simple pathway for the preparation of D‐cycloserine is presented. The intermediates and D‐cycloserine were characterized by FT‐IR, 1H‐NMR spectra and elemental analysis. D‐Cycloserine can inhibit the growth of Mycobacterium tuberculosis and can be used as a second‐line drug for the treatment of tuberculosis, especially for the use in developing countries.
A survey in the park: Methodological and practical problems associated with geophysical investigation in a late Victorian municipal park
Authors: Parkyn Andrew
Published: September 2010

The survey of Pudsey Park is a geophysical investigation of a late Victorian municipal park. The aim of the survey was to use geophysical techniques to identify the park's changing designs over a 120 year period. An initial design for the park was located during the desk‐based assessment, however, it was unclear how much of the original plan had been implemented. It was suspected that Pudsey Park's design has been simplified over time. The project also aimed to identify a suitable sampling strategy for studying park and garden sites by using high‐resolution surveys and multiple probe separations for varying depths of detection during earth resistance survey. It was hoped that multiple electrode separations combined with a high density survey could be used to differentiate the signal responses from the modern park designs and earlier design schemes. The choice of strategy is at a significantly higher resolution than guidelines for geophysical investigations for traditional archaeological features. The survey provided highly detailed but complicated data sets; areas of the park have had several redesigns, often where the modern scheme masks previous designs. A number of ‘hard’ and ‘soft’ landscaping features were identified including the foundations of the original bandstand (now replaced) and former flower beds. The 0.25 m probe separation surprisingly produced the most defined data with the greatest level of information due to the increased spatial resolution. The geophysical investigation is the first of its kind to investigate a Victorian municipal park in its entirety. The survey validates the importance of high‐resolution survey in the study of parks and gardens and also provides a reference data set for future work where poorer documentation hinders interpretation. The geophysics data, together with the accompanying Geographical Information System database produce a unique and detailed picture of a Victorian park from its inception through 120 years of development. Copyright © 2010 John Wiley & Sons, Ltd.
Beyond partnerism: toward a more expansive research agenda on multi‐stakeholder collaboration for responsible business
Authors: Bendell Jem , Collins Eva , Roper Juliet
Published: September 2010

The paper sets the context for the special issue on ‘Collaborative engagement for sustainability in the Asia‐Pacific region’. The relevance and risks of cross‐sectoral strategic alliances for sustainable development vary greatly across the region. Potential alliances face unique hurdles given different public challenges, political systems, types of development, forms of civil society and cultural traditions. The four papers in the special issue highlight some key issues that have not been well explored in the current literature, such as the role of collaboration in state‐centric societies, the applicability of a tri‐sectoral model (of state, business and civil society) in places where ownership and accountability are more complex, and the business rationale for partnering when there is limited consumer, media or civil society demand for voluntary action. In this special edition the papers bring further light to some of these debates. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment.
ChemInform Abstract: Orthoester‐Dependent Alcoholysis of Lactones. Facile Preparation of 4‐ Alkoxybutanoates and 5‐Alkoxypentanoates.
Authors: KING S. A.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Hydrogenation of 2‐Benzylidenesuccinic Acid 4‐((4‐BOC‐Amino) ‐1‐piperidide) Monoamide: Key Step in a Process for Large Scale Preparation of a Renin Inhibitor.
Authors: JENDRALLA H.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mild, Zinc‐Induced Defluorination of Butatrienes: Stereoselective Formation of Divinylacetylene Derivatives.
Authors: MORKEN P. A. , BURTON D. J. , SWENSON D. C.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mechanisms of Aromatic Lithiation: Influence of Aggregation and Directing Groups.
Authors: VAN EIKEMA HOMMES N. , VON RAGUE SCHLEYER P.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The ((Methyloxy)imino)methyl Moiety as a Bioisoster of Aryl. A Novel Class of Completely Aliphatic β‐Adrenergic Receptor Antagonists.
Authors: MACCHIA B. , BALSAMO A. , BRESCHI M. C. , CHIELLINI G. , MACCHIA M. , MARTINELLI A. , MARTINI C. , NARDINI C. , NENCETTI S. , ROSSELLO A. , SCATIZZI R.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of a Strategy for the Synthesis of the Spherical Hydrocarbon p‐(42.58)Decahedrane.
Authors: SHEN C.‐C. , PAQUETTE L. A.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diels‐Alder Reactions with 2‐Methylpyridazin‐3(2H)‐ones Bearing Electron‐Withdrawing Substituents at the 4‐ or 5‐Position.
Authors: FARINA F. , MARTIN M. V. , ROMANACH M.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New and Improved Preparation of Acyclic σ‐Dialkoxyphosphoranes.
Authors: MATHIEU‐PELTA I. , EVANS S. A. JUN.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mixed Tetramers of sec‐Butyllithium and 3‐Methoxypropyllithium; Degree of Intracluster Etheration and Reactivity of sec‐Butyllithium Towards Ethylene.
Authors: SCHMITZ R. F. , DE KANTER F. J. J. , SCHAKEL M. , KLUMPP G. W.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of the 4 Possible Stereoisomers of 3‐O‐Stearoyl C36‐ Corynomycolic Acid and Derived Lipopeptides.
Authors: EUSTACHE J. , GROB A.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diastereospecific Synthesis of 2′‐ or 3′‐C‐Branched Nucleosides Through Intramolecular Free‐Radical Capture by Silicon‐Tethered Acetylene.
Authors: XI Z. , RONG J. , CHATTOPADHYAYA J.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Ampicillin Derivatives with Glyoxyloylbenzhydrazones as Side Chains.
Authors: HEINISCH L. , HANSCHKE K. G. , WILLITZER H. , MOELLMANN U. , TRESSELT D. , STENGEL K. , ECKARDT K. , KLEINWAECHTER W.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fibrous Monolithic Ceramics. Part 3. Mechanical Properties and Oxidation Behavior of the Silicon Carbide/Boron Nitride System.
Authors: BASKARAN S. , HALLORAN J. W.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Vanadium Peroxide Complexes
Authors: BUTLER A. , CLAGUE M. J. , MEISTER G. E.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organic Diradicals and Polyradicals: From Spin Coupling to Magnetism?
Authors: RAJCA A.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Atomic Distribution in LnFexAl12‐x Compounds with Ln: Tb, Dy, Ho, Er, Tm and Fe Concentrations of x ≈ 5 Studied by Neutron Diffraction.
Authors: SCHAEFER W. , KOCKELMANN W. , WILL G. , FISCHER P. , GAL J.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Strongly Enhanced Paramagnetism in CeNi5‐xGax and LaNi3Ga2.
Authors: TANG J. , LI L. , O'CONNOR C. J. , LEE Y. S.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Structural Study of (+)‐5‐Acetyl‐6‐methyl‐5p‐ tolylsulfinyl‐3a,4,5,6‐tetrahydro‐(3H)‐benzofuran‐2‐one.
Authors: ALEXANDRE C. , BELKADI O. , ROUESSAC F.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lipase‐Catalyzed Aminolysis and Ammonolysis of β‐Ketoesters. Synthesis of Optically Active β‐Ketoamides.
Authors: GARCIA M. J. , REBOLLEDO F. , GOTOR V.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cobalt‐Catalyzed Allylic and Benzylic Oxidations with Dioxygen in the Presence of Ethyl 2‐Oxocyclopentanecarboxylate.
Authors: PUNNIYAMURTHY T. , IQBAL J.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N‐Hetaryl‐ethylenes. Part 7. N‐Alkenylation of Carbazole, Phenoxazine and Phenothiazine with Carbonyl Compounds.
Authors: KHLEBNIKOV A. I. , ANFINOGENOV V. A. , MOSKALEV N. V. , FILIMONOV V. D.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of Fluoro Halogens. Part 13. New Possibilities for the Oxidative and Nucleophilic Fluorination of Bromo‐Substituted Complex Esters by Hexachloromelamine‐HF.
Authors: CHUVATKIN N. N. , PANTELEEVA I. YU. , KURSKII YU. A. , BOGUSLAVSKAYA L. S.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Thiosubstituted Butadienes Obtained from 1,3‐Di‐H‐ tetrachlorobutadiene and 2H‐Pentachlorobutadiene.
Authors: IBIS C. , SAYIL C.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transformation of Aniline on a Promoted Nickel‐Chromium Catalyst at High Hydrogen Pressure.
Authors: MAILYUBAEV B. T. , UALIKHANOVA A.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Nitration versus Oxidative Dealkylation of Hydroquinone Ethers with Nitrogen Dioxide.
Authors: RATHORE R. , BOSCH E. , KOCHI J. K.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Synthetic Route to 1,3‐Disubstituted Naphthalenes.
Authors: STREKOWSKI L. , WYDRA R. L. , KISELYOV A. S. , BAIRD J. H. , BURRITT A. , COXON J. M.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Silver‐Catalyzed Heterocyclization: First Total Synthesis of the Naturally Occurring cis 2‐Hexadecyl‐3‐hydroxy‐4‐methylene Butyrolactone.
Authors: DALLA V. , PALE P.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Derivatives of 1,3‐Dioxanes with Mesomorphic Properties.
Authors: MURZA M. M. , GORBENKO M. M.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Free Radical Rearrangement of Alkenyl Epoxy Silanes. Isolation of . alpha.‐Trimethylsilyl Aldehydes.
Authors: ROBERTSON J. , BURROWS J. N.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Model Studies Towards the Total Synthesis of Asteriscanolide.
Authors: BOOKER‐MILBURN K. I. , COWELL J. K. , HARRIS L. J.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient and Enantioselective Synthesis of a Chiral Primary Amine.
Authors: SON Y. , PARK C. , KOH J. S. , CHOY N. , LEE C. S. , CHOI H. , KIM S. C. , YOON H.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mitsunobu Reactions of Glycals with Phenoxide Nucleophiles are SN2′‐ Selective.
Authors: SOBTI A. , SULIKOWSKI G. A.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of Glucal Halohydrins: Effect of the Halide on Epoxide Formation.
Authors: MARZABADI C. H. , SPILLING C. D. , TYLER L. M.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.