bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Carbetocin and Oxytocin on Haemodynamic among Women with Post-Partum Hemorrhage after Caesarean Section: A Single Blind Parallel Arm Randomized Controlled Trial
Authors: Choudhury Farhana Haque , Ahmed Shahnaz , Tanzin Syeda Tania , Rahman Silvia , Fatema Naheed , Khatun Kashifa
Published: April 2024

Background: Management of haemodynamic among women with post-partum hemorrhage after caesarean section.
Objective: The purpose of the present study was to compare the effect of carbetocin and oxytocin on haemodynamic among women with post-partum hemorrhage after caesarean section.
Methodology: This randomized controlled trial was conducted in the Department of Obstetrics and Gynaecology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from July 2015 to December 2015 for a period of six months. Pregnant women diagnosed on the standard criteria admitted in BSMMU, Dhaka, Bangladesh were selected as study population by consecutive type of sampling. Randomization was performed according to computer generated simple random sampling method. An Uterotonic was an agent used to induce contraction or greater tonicity of the uterus. Then the patients were monitored per operatively and post operatively. All the information was recorded in data collection sheet. Main outcome variables were estimated blood loss.
Results: A total number of 96 pregnant women were recruited for this s tudy of which 48 cases were enrolled in group I and the rest of 48 case were enrolled in group II. The mean age with SD of the group I and group II were 24.4±4.7 years and 24.7±3.7 years (p=0.729). Before administration of drug, mean systolic blood pressure was found 115.6±5.8 mmHg in group I and 114.8±7.8 mmHg in group II. At 24 hours after caesarean section, mean systolic blood pressure was found 116.9±5.8 mmHg in group I and 113.9±8.8 mmHg in group II (p>0.05). Before administration of drug, mean diastolic blood pressure was found 75.8±7.9 mmHg in group I and 76.9±9.9 mmHg in group II. At 24 hours after caesarean section, mean diastolic blood pressure was found 76.7±6.6 mmHg in group I and 76.1±7.2 mmHg in group II (p>0.05). Before administration of drug, mean maternal blood loss was found 376.4±110.4 ml in group I and 439.4±199.9 ml in group II. At 24 hours after caesarean section, mean maternal blood loss was found 468.2±121.9 ml in group I and 532.6±243.0 ml in group II (p>0.05).
Conclusion: In conclusion the systolic blood pressure, diastolic blood pressure and blood loss are not significantly varied in group I and II.
Journal of National Institute of Neurosciences Bangladesh, July 2023;9(2):141-146
Subclavian Steal Syndrome Presented with Recurrent Syncope: A Case Report
Authors: Rassel Mohammad Aftab , Islam Mohammad Ariful , Elyas Dewan Md , Razzaque Mohammad Aminur
Published: April 2024

The Subclavian Steal Syndrome is a rare vascular disorder that results from the stenosis of the subclavian artery proximal to the origin of the vertebral artery. This obstruction causes the retrograde blood flow in the ipsilateral vertebral artery called “steal” because it steals blood from the cerebral circulation. We report a case of subclavian steal syndrome in a 57 yrs old male with HTN and CKD. The patient presented to the emergency department of a tertiary-level hospital with a one-week history of recurrent syncopal attack with an injury mark during his last episode. He had no known cardiac structural abnormality. Further clinical examination revealed absent radial and brachial pulse and non-recordable blood pressure in the left arm. Duplex study of the left upper limb arterial system showed left subclavian artery stenosis with the retrograde flow in the left vertebral artery (subclavian-vertebral steal). A coronary angiogram confirmed proximal stenosis of the subclavian artery. The condition was successfully treated with left subclavian stenting.
Journal of National Institute of Neurosciences Bangladesh, July 2023;9(2):161-167
A Rare Case Report of Acrania
Authors: Arman DM , Mukherjee Sudipta Kumer , Islam Joynul
Published: April 2024

Acrania is a rare congenital anomaly and characterized by partial or complete absence of the calvarium. Although acrania associated with anencephaly is a well-recognized entity but isolated acrania is a rare anomaly.  Ultrasound allows early diagnosis of this anomaly. The fetus was found to have a completely formed brain, base of the skull and facial structures but lacking a cranium.  Authors present a rare case of acrania.
 Journal of National Institute of Neurosciences Bangladesh, July 2023;9(2):157-160
Genetic Basis of Alzheimer's Disease: Bangladesh Perspective
Authors: Hakim Maliha
Published: April 2024

Abstract Not Available
Journal of National Institute of Neurosciences Bangladesh, July 2023; 9(2):96-97
Nguồn lực tài chính cho phát triển khoa học công nghệ và đổi mới sáng tạo tại Việt Nam
Authors: Đỗ Hoài Linh
Published: April 2024

Bài viết tập trung nghiên cứu về nguồn lực tài chính cho phát triển khoa học công nghệ và đổi mới sáng tạo trên các khía cạnh: (i) Khái quát về hai nhóm nguồn lực tài chính cho phát triển khoa học công nghệ và đổi mới sáng tạo trên các khía cạnh gồm: nguồn tài chính từ ngân sách nhà nước và nguồn tài chính ngoài ngân sách; (ii) Kinh nghiệm quốc tế từ khu vực Châu Âu, Châu Mỹ và Châu Á về các nguồn lực nguồn lực tài chính cho phát triển khoa học công nghệ và đổi mới sáng tạo; (iii) Hiện trạng về các nguồn lực tài chính cho phát triển khoa học công nghệ và đổi mới sáng tạo tại Việt Nam. Dựa trên cơ sở lý luận được tổng hợp, nhóm tác giả đề xuất một số khuyến nghị chính sách để nâng cao hiệu quả huy động và sử dụng nguồn lực tài chính cho phát triển khoa học công nghệ và đổi mới sáng tạo trong giai đoạn từ nay đến 2030.
Lost opportunities for globalisation, digitalisation, and socially sustainable education? Advocating for digital and global Bildung in Swedish upper secondary schools
Authors: Bäcke Maria , Vigmo Sylvi
Published: April 2024

In this article, we point to how the making visible of diverse linguistic, digital, and cultural competences can contribute to more sustainable and inclusive classroom contexts and future societies. Western notions of universal knowledge reproduces a western way of viewing the world and, as a result, this usually discounts alternative knowledge systems, which perpetuates inequality and may cause tensions in today’s diverse classrooms. Our 2022 pilot study, drawing on an online survey with more than 700 respondents and focus group interviews with 27 participants, indicates that for some multiethnic, multi-abled, and otherwise diverse upper secondary students underlying, often ethnocentric, norms of Swedish education create hurdles in educational contexts. Firstly, in the Swedish context, non-normative and often global experiences are not recognised at school. Secondly, topics addressed in the courses they take are primarily focused on aspects originating in a Swedish, Nordic, or Western tradition. Curricular policies and classroom practices must take lost opportunities, which we argue are not socially sustainable, into account as a more global and holistic approach when articulating what educational learning is supposed to be about, for, and for whom, and thus integrating learning, digitalisation, and social sustainability.
Describing undergraduate students’ reasoning and use of evidence during argumentation about socioscientific issues systems
Authors: Jimenez P. Citlally , Alred Ashley R. , Dauer Jenny M.
Published: April 2024

Introduction

We conducted research in a post-secondary, large-enrollment science literacy course that asks students to apply multidisciplinary scientific evidence when providing an argument about the potential social and ecological consequences of policy solutions to socioscientific issues (SSI).

Methods

Coding schemes were developed to describe students’ levels of proficiency in constructing arguments about the nature of SSI systems and were created through inductive coding of student arguments about SSI systems embedded within a structured decision-making process.

Results

The coding schemes included student practices in 1) providing reasoning about the potential consequences of multiple solutions for an SSI, 2) linking evidence to reasoning, and 3) sources of evidence. In the highest level in the reasoning coding scheme, students used clear and traceable scientific evidence to address an assumption by specifying how (a mechanism) or by how much, an SSI solution might satisfy a desired policy objective.

Discussion

The resulting framework describes how students apply multidisciplinary scientific evidence to support their SSI reasoning, which may aid researchers and educators in exploring how students interpret and integrate scientific evidence in an SSI-context, with the ultimate goal of bolstering students’ ability to reason about evidence outside the classroom.
Integration of electric vehicle into smart grid: a meta heuristic algorithm for energy management between V2G and G2V
Authors: Srihari G. , Krishnam Naidu R. S. R. , Falkowski-Gilski Przemysław , Bidare Divakarachari Parameshachari , Kiran Varma Penmatsa Ravi
Published: April 2024

Recently, Electric Vehicles (EV) have been providing fast response and substantial progress in the power generation model. Further, EVs are exploited as adaptable Energy Storage Systems (ESSs) and show a promising performance in ancillary service markets to increase the demand of Smart Grid (SG) integration. The expansion of Vehicle-to-Grid concept has created an extra power source when renewable energy sources are not available. Yet, numerous operational problems still are required to be considered for EV implementation to turn out to be extensive. Even the development of Photo-Voltaic (PV) technology creates a problem in SGs when used for EV charging. Because of this, the Energy Management System (EMS) is required to handle charging requirements and deal with the intermittent generation. Here, in this research, an Improved Honey Badger algorithm (IHBA) is proposed for integrating SGs with EV parking lot, solar panels, and dynamic loads at the Point of Common Coupling (PCC). The proposed IHBA uses a dynamic programming method to optimize the charging Grid-to-Vehicle (G2V) or discharging Vehicle-to-Grid (V2G) profiles of the EVs using the forecasts of PV generation. This algorithm considers user preferences while also lowering reliance on the grid and maximizing SG effectiveness. The study’s findings show that the Honey Badger method is efficient in resolving issues involving large search spaces. The developed method is used to optimize charging and discharging of EV which is tested in MATLAB to obtain a stable load profile. From the evaluation of obtained results, it is evident that the IHBA controller outperforms the WOA and EHO controllers in terms of total harmonic distortion voltage (3.12%), power loss (0.197 kW) and efficiency (98.47%).
A preliminary study of optimal treatment response rates in patients undergoing hepatic arterial infusion chemotherapy combined with molecular targeting and immunotherapy
Authors: Li Mei , Liao Jun , Wang Li , Lv Tianye , Sun Qianfu , Xu Yan , Guo Zhi , Quan Manman , Qin Hao , Yu Haoyang , Zhang Kai , Xing Wenge , Yu Haipeng
Published: April 2024

Objectives

This study aimed to examine the effectiveness of the best response rate (BRR) as a surrogate for overall survival (OS), using the modified Response Evaluation Criteria in Solid Tumors (mRECIST), in patients with unresectable hepatocellular carcinoma (HCC) undergoing hepatic arterial infusion chemotherapy (HAIC) with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) combined with molecular targeting and immunotherapy.

Methods

This study enrolled 111 consecutive patients who had complete imaging data. The median age of patients was 58 years (IQR 50.5-65.0). Among the patients, those with Barcelona Clinic Liver Cancer (BCLC) stage A, BCLC stage B, and BCLC stage C comprised 6.4%, 19.1%, and 73.6%, respectively. The optimal threshold of BRR can be determined using restricted cubic splines (RCS) and the rank sum statistics of maximum selection. Survival curves of patients in the high rating and low rating groups were plotted. We then used the change-in-estimate (CIE) method to filter out confounders and the inverse probability of treatment weighting (IPTW) to balance confounders between the two groups to assess the robustness of the results.

Results

The median frequency of the combination treatment regimens administered in the overall population was 3 times (IQR 2.0-3.0). The optimal BRR truncation value calculated was −0.2. Based on this value, 77 patients were categorized as the low rating group and 34 as the high rating group. The differences in the OS between the high and low rating groups were statistically significant (7 months [95%CI 6.0-14.0] vs. 30 months [95%CI 30.0-]; p< 0.001). Using the absolute 10% cut-off value, the CIE method was used to screen out the following confounding factors affecting prognosis: successful conversion surgery, baseline tumor size, BCLC stage, serum total bilirubin level, number of interventional treatments, alpha-fetoprotein level, presence of inferior vena cava tumor thrombus, and partial thrombin activation time. The survival curve was then plotted again using IPTW for confounding factors, and it was found that the low rating group continued to have better OS than the high rating group. Finally, the relationship between BRR and baseline factors was analyzed, and inferior vena cava tumor thrombus and baseline tumor size correlated significantly with BRR.

Conclusions

BRR can be used as a surrogate endpoint for OS in unresectable HCC patients undergoing FOLFOX-HAIC in combination with molecular targeting and immunotherapy. Thus, by calculating the BRR, the prognosis of HCC patients after combination therapy can be predicted. Inferior vena cava tumor thrombus and baseline tumor size were closely associated with the BRR.
A low-glucose eating pattern is associated with improvements in glycemic variability among women at risk for postmenopausal breast cancer: an exploratory analysis
Authors: Jospe Michelle R. , Liao Yue , Giles Erin D. , Hudson Barry I. , Slingerland Joyce M. , Schembre Susan M.
Published: April 2024

Background

High glycemic variability (GV) is a biomarker of cancer risk, even in the absence of diabetes. The emerging concept of chrononutrition suggests that modifying meal timing can favorably impact metabolic risk factors linked to diet-related chronic disease, including breast cancer. Here, we examined the potential of eating when glucose levels are near personalized fasting thresholds (low-glucose eating, LGE), a novel form of timed-eating, to reduce GV in women without diabetes, who are at risk for postmenopausal breast cancer.

Methods

In this exploratory analysis of our 16-week weight loss randomized controlled trial, we included 17 non-Hispanic, white, postmenopausal women (average age = 60.7 ± 5.8 years, BMI = 34.5 ± 6.1 kg/m2, HbA1c = 5.7 ± 0.3%). Participants were those who, as part of the parent study, provided 3–7 days of blinded, continuous glucose monitoring data and image-assisted, timestamped food records at weeks 0 and 16. Pearson’s correlation and multivariate regression were used to assess associations between LGE and GV, controlling for concurrent weight changes.

Results

Increases in LGE were associated with multiple unfavorable measures of GV including reductions in CGM glucose mean, CONGA, LI, J-Index, HBGI, ADDR, and time spent in a severe GV pattern (r = −0.81 to −0.49; ps < 0.044) and with increases in favorable measures of GV including M-value and LBGI (r = 0.59, 0.62; ps < 0.013). These associations remained significant after adjusting for weight changes.

Conclusion

Low-glucose eating is associated with improvements in glycemic variability, independent of concurrent weight reductions, suggesting it may be beneficial for GV-related disease prevention. Further research in a larger, more diverse sample with poor metabolic health is warranted.

Clinical trial registration: ClinicalTrials.gov, NCT03546972.
Harnessing the cGAS-STING pathway to potentiate radiation therapy: current approaches and future directions
Authors: Colangelo Nicholas W. , Gerber Naamit K. , Vatner Ralph E. , Cooper Benjamin T.
Published: April 2024

In this review, we cover the current understanding of how radiation therapy, which uses ionizing radiation to kill cancer cells, mediates an anti-tumor immune response through the cGAS-STING pathway, and how STING agonists might potentiate this. We examine how cGAS-STING signaling mediates the release of inflammatory cytokines in response to nuclear and mitochondrial DNA entering the cytoplasm. The significance of this in the context of cancer is explored, such as in response to cell-damaging therapies and genomic instability. The contribution of the immune and non-immune cells in the tumor microenvironment is considered. This review also discusses the burgeoning understanding of STING signaling that is independent of inflammatory cytokine release and the various mechanisms by which cancer cells can evade STING signaling. We review the available data on how ionizing radiation stimulates cGAS-STING signaling as well as how STING agonists may potentiate the anti-tumor immune response induced by ionizing radiation. There is also discussion of how novel radiation modalities may affect cGAS-STING signaling. We conclude with a discussion of ongoing and planned clinical trials combining radiation therapy with STING agonists, and provide insights to consider when planning future clinical trials combining these treatments.
The fly route of extended-spectrum-β-lactamase-producing Enterobacteriaceae dissemination in a cattle farm: from the ecosystem to the molecular scale
Authors: Caderhoussin Alann , Couvin David , Gruel Gaëlle , Quétel Isaure , Pot Matthieu , Arquet Rémy , Dereeper Alexis , Bambou Jean-Christophe , Talarmin Antoine , Ferdinand Séverine
Published: April 2024

Introduction

This study aimed to understand the origin and to explain the maintenance of extended-spectrum β-lactamase (ESBL) Enterobacteriaceae isolated from food-producing animals in a third-generation cephalosporin (3GC)-free farm.

Methods

Culture and molecular approaches were used to test molecules other than 3GC such as antibiotics (tetracycline and oxytetracycline), antiparasitics (ivermectin, flumethrin, fenbendazol, and amitraz), heavy metal [arsenic, HNO3, aluminum, HNO3, cadmium (CdSO4), zinc (ZnCl2), copper (CuSO4), iron (FeCl3), and aluminum (Al2SO4)], and antioxidant (butylated hydroxytoluene) as sources of selective pressure. Whole-genome sequencing using short read (Illumina™) and long read (Nanopore™) technologies was performed on 34 genomes. In silico gene screening and comparative analyses were used to characterize the genetic determinants of resistance, their mobility, and the genomic relatedness among isolates.

Results

Our analysis unveiled a low diversity among the animal ESBL-producing strains. Notably, E. coli ST3268 was recurrently isolated from both flies (n = 9) and cattle (n = 5). These E. coli ST3268/blaCTX-M-15/blaTEM-1B have accumulated multiple plasmids and genes, thereby representing a reservoir of resistance and virulence factors. Our findings suggest that flies could act as effective mechanical vectors for antimicrobial gene transfer and are capable of transporting resistant bacteria across different environments and to multiple hosts, facilitating the spread of pathogenic traits. A significantly higher mean minimum inhibitory concentration of oxytetracycline (841.4 ± 323.5 mg/L vs. 36.0 ± 52.6 mg/L, p = 0.0022) in ESBL E. coli than in non-ESBL E. coli and blaCTX-M-15 gene overexpression in oxytetracycline-treated vs. untreated ESBL E. coli (RQOxy = 3.593, p = 0.024) confirmed oxytetracycline as a source of selective pressure in ESBL E. coli.

Discussion

The occurrence of ESBL E. coli in a farm without 3GC use is probably due to an as yet undefined human origin of Enterobacteriaceae blaCTX-M-15 gene transmission to animals in close contact with cattle farm workers and the maintenance of the local ESBL E. coli reservoir by a high fly diversity and oxytetracycline selective pressure. These findings highlight the critical need for stringent vector control to mitigate antimicrobial resistance spread for preserving public health. Addressing this issue necessitates a multifaceted approach combining microbial genetics, vector ecology, and farm management practices.
Integrative analysis of proteomics and lipidomic profiles reveal the fat deposition and meat quality in Duroc × Guangdong small spotted pig
Authors: Wu Zhuosui , Wang Zhonggang , Wang Pan , Cheng Leiyan , Li Jianhao , Luo Yanfeng , Yang Linfang , Li Linfeng , Zeng Jianhua , Hu Bin
Published: April 2024

Introduction

This study aims to explore the important factors affecting the characteristics of different parts of pork.

Methods

Lipidomics and proteomics methods were used to analyze DAL (differential lipids) and DAPs (differential proteins) in five different parts (longissimus dorsi, belly meat, loin, forelegs and buttocks) of Duhua pig (Duroc × Guangdong small spotted pig), to identify potential pathways affecting meat quality, investigating fat deposition in pork and its lipid-protein interactions.

Results

The results show that TG (triglyceride) is the lipid subclass with the highest proportion in muscle, and the pathway with the most significantly enriched lipids is GP. DAP clustered on several GO terms closely related to lipid metabolism and lipogenesis (lipid binding, lipid metabolism, lipid transport, and lipid regulation). In KEGG analysis, there are two main DAP aggregation pathways related to lipid metabolism, namely Fatty acid degradation and oxidative phosphorylation. In PPI analysis, we screened out 31 core proteins, among which NDUFA6, NDUFA9 and ACO2 are the most critical.

Discussion

PC (phosphatidylcholine) is regulated by SNX5, THBS1, ANXA7, TPP1, CAVIN2, and VDAC2 in the phospholipid binding pathway. TG is regulated by AUH/HADH/ACADM/ACADL/HADHA in the lipid oxidation and lipid modification pathways. Potential biomarkers are rich in SFA, MUFA and PUFA respectively, the amounts of SFA, MUFA and PUFA in the lipid measurement results are consistent with the up- and down-regulation of potential biomarker lipids. This study clarified the differences in protein and lipid compositions in different parts of Duhua pigs and provided data support for revealing the interactions between pork lipids and proteins. These findings provide contributions to the study of intramuscular fat deposition in pork from a genetic and nutritional perspective.
Evaluating Driver Preferences for In-Vehicle Displays during Distracted Driving Using Driving Simulators
Authors: Li Liang , Yang Zijiang , Zeng Jie , Carlos Chacon Quintero Juan
Published: April 2024

Research on the impact of distracted driving on in-vehicle displays was conducted through a user preference experiment based on simulated driving. The development of automotive automation and multi-screen in-vehicle displays has improved the driving experience but also increased distracted driving. Typical scenarios and information needs were identified through user research, and a simulated driving platform was used to record user choices of different display modes and their reaction times after being distracted. Questionnaires were analyzed using the Analytic Hierarchy Process (AHP). Results showed that in the manual driving group, users preferred Head-Up Display (HUD), which had the highest efficiency in terms of reaction time. The study confirmed that as automation levels increase, distraction scenarios will change, and user focus will shift from safety to experience.
Gas-Flow-Rate Inversion Based on Experiments and Simulation of Flame Combustion Characteristics in a Drilling Blowout
Authors: Zhang Xuliang , Liu Xiao , Huang Wenxin , Hu Junjie , Du Yonghong , Ge Dongwei , Sun Xiaohui
Published: April 2024

Accurately estimating the gas-flow rate at a wellhead to invert the formation pressure and production capacity information can be the basis for subsequent well-killing parameter design following oil and gas-well drilling blowout and ignition. Based on the multicomponent characteristics of the blowout gas and the turbulence intensity of the blowout flame, as well as the effects of complex factors such as environmental wind direction, wind speed, and wellhead structure, a numerical model for actual drilling blowout ignition is established. Jet-flame experiments are conducted under blowout conditions to verify the accuracy of the model. The temperature and radiation fields and flame morphologies of the well jet flow flame under different lateral wind speeds, well jet flow rates, and wellhead diameters are analyzed. Previous studies have found that as the lateral wind speed increases, the maximum temperature and maximum thermal radiation intensity of the blowout flame first decrease and then increase. However, as the amount of well jet increases, although the flame influence area increases, the maximum temperature does not increase significantly, and the maximum thermal radiation intensity actually decreases. Based on experimental and numerical simulation datasets, a high-yield gas-well jet volume prediction method based on the flame height and thermal radiation intensity of the well jet flow is constructed, which has important engineering application value for achieving successful well killing following well jet ignition.
Budget loans stimulating regions` infrastructural development, their types and prospects
Authors: Сангинова Л.Д.
Published: April 2024

В статье проведен сравнительный анализ бюджетных кредитов субъектам Российской Федерации, стимулирующих их инфраструктурное развитие. Выявлено достаточно много общих черт двух видов кредитов, с преимуществом инфраструктурных бюджетных кредитов для заемщиков, по сравнению с кредитами, предоставляемыми Федеральным казначейством за счет остатка средств на едином счете федерального бюджета. Определены возможные риски для федерального бюджета в связи с предоставлением бюджетных кредитов, определены пути минимизации. Проведенный анализ действующей методики отбора субъектов при определении лимитов предоставляемых бюджетных кредитов показал необходимость ее доработки. Предложено ее усовершенствовать с учетом таких показателей, как обеспеченность субъектов Российской Федерации той или иной инфраструктурой, степенью ее изношенности и потребностью в модернизации и обновлении. При отборе проектов предлагается оценивать качественные показатели — влияние реализации проектов на уровень ВРП, социально-экономическое развитие регионов, вклад проекта в достижение стратегических национальных целей развития, национальных проектов и государственных программ. В любом случае, бюджетные кредиты, стимулирующие инфраструктурное развитие регионов, должны быть самоокупаемыми. Предложения могут быть учтены при предоставлении следующих траншей бюджетных кредитов.

The article provides a comparative analysis of budget loans issued to constituent entities of the Russian Federation to stimulate their infrastructural development. Quite a lot of common features of the two types of loans have been identified, with the advantage of infrastructure budget loans for borrowers compared to loans provided by the Federal Treasury from the balance of funds in the single account of the federal budget. Possible risks for the federal budget in connection with the provision of budget loans have been identified, and ways to minimize them have been identified. The analysis of the current methodology for selecting subjects when determining the limits of provided budget loans showed the need for its refinement. It is proposed to improve it taking into account such indicators as the provision of constituent entities of the Russian Federation with one or another infrastructure, the degree of its deterioration and the need for modernization and renewal. When selecting projects, it is proposed to evaluate quality indicators — the impact of project implementation on the level of GRP, the socio-economic development of regions, the project’s contribution to the achievement of strategic national development goals, national projects and government programs. In any case, budget loans that stimulate the infrastructural development of regions must be self-paying. The proposals may be taken into account when providing the next tranches of budget loans.
Methodology of building the structure of economic systems
Authors: Герасимов Б.Н.
Published: April 2024

В любой области деятельности производится выбор совокупности атрибутов, которые формируют и поддерживают типологию объекта управления экономических систем типа «организация». Основные атрибуты процессного управления используются для определения и использования методологических инструментов при исследовании, построении и реформировании структуры экономических систем на основе полицентрического подхода. Разработана модель проектирования структуры процессного управления экономических систем на основе содержания и взаимодействия атрибутов подпроцессов управления. Разработана технология формирования содержания основных атрибутов нормативного состояния подпроцесса управления в экономических системах. Использование полицентрического подхода в качестве главного методологического инструмента позволило повысить качество и результативность построения и функционирования объектов управления в экономических и социальных средах.

In any field of activity, a set of attributes is selected that form and support the typology of the management object of economic systems of the "organization" type. The main attributes of process management are used to identify and use methodological tools in research. building and reforming the structure of economic systems based on a polycentric approach. A model has been developed for designing the structure of process management of economic systems based on the content and interaction of attributes of management subprocesses. The technology of forming the content of the main attributes of the normative state of the management subprocess in economic systems has been developed. The use of the polycentric approach as the main methodological tool has made it possible to improve the quality and effectiveness of the construction and functioning of management facilities in economic and social environments.
Efecto de la gamificación en el aprendizaje activo: Revisión sistemática
Authors: Ulloa Arias Diego Fernando , Carcausto Calla Wilfredo
Published: April 2024

Una de las metodologías y alternativa innovadora para el aprendizaje en estudiantes universitarios es la gamificación. Este estudio tiene como objetivo identificar cuáles son las capacidades, efectos y factores desarrollados por la gamificación en el aprendizaje activo, así como conocer los principales aportes de los autores. El estudio emplea una metodología de revisión sistemática propuesta en la declaración PRISMA. Se utilizaron publicaciones de tres bases de datos: Web of Science, Scielo y Scopus entre el año 2018 y 2023, considerando los descriptores de búsqueda: “Gamificación” y “aprendizaje activo” y mediante un proceso de inclusión y exclusión, se llegó a una muestra final de 30 artículos. Como conclusión, se evidencia que la gamificación influye significativamente en el aprendizaje activo del estudiante universitario, desarrollando capacidades como la comunicación, resolución de problemas y habilidades sociales, además, factores del aprendizaje como la motivación, nuevos entornos y autonomía.
Insegurança Alimentar e aspectos da alimentação de sujeitos com excesso de peso de um município paraibano
Authors: Silva Ana Paula Melo da , Medeiros Juliana Fernandes de , Martins Ana Cristina Silveira , Vieira Tatielle de Lima , Correia Yasmin Andrade Rufino , Soares Kassio Bezerra , Silva Sebastião Giliard Oliveira , Santos Gracielle Malheiro dos
Published: April 2024

O objetivo deste artigo foi descrever os aspectos relacionados à segurança alimentar e nutricional entre indivíduos com sobrepeso e obesidade residentes em um território de abrangência de uma Unidade Básica de Saúde de um município do interior da Paraíba. Estudo transversal, descritivo com amostra intencional, realizado em janeiro de 2020 no município de Nova Floresta, Paraíba. Utilizou-se questionário estruturado com dados socioeconômicos; avaliação de segurança alimentar através da Escala Brasileira de Insegurança Alimentar; padrão de consumo; e avaliação antropométrica. Observa-se que a maior parte dos entrevistados eram do sexo feminino, com casa própria quitada, sabendo ler e escrever com facilidade e sem renda fixa. A prevalência foi maior para a insegurança alimentar e seus diferentes níveis, bem como, principalmente entre as mulheres, com mais baixo nível de escolaridade e com excesso de peso. Durante a semana, a maioria dos entrevistados realiza refeições em casa e com outras pessoas, sentado à mesa; ao seu término acham que comeram de forma suficiente. Os alimentos mais consumidos todos os dias ou duas vezes na semana são alimentos básicos da cultura alimentar brasileira. Os entrevistados consomem com menor frequência alimentos processados e ultraprocessados.
Avaliação do Programa Nacional de Suplementação de Vitamina A: o olhar dos profissionais da Atenção Primária à Saúde
Authors: Sousa Letícia Cristina Machado de , Vilela Pamella Arrais , Siqueira Carolyne Socorro Pastana , Santiago Fernanda de Jesus , Nishioka Patrícia , Rinaldi Ana Elisa Madalena , Silva Luciana Saraiva da
Published: April 2024

A carência de vitamina A é considerada um problema de saúde pública em vários países de baixa e média renda, inclusive no Brasil. Nesse contexto, foi instituído o Programa Nacional de Suplementação de Vitamina A (PNSVA), com o intuito de suplementar as crianças de 6 a 59 meses com megadoses dessa vitamina. O objetivo deste estudo foi avaliar o conhecimento dos profissionais a respeito desse programa, além da operacionalização, do funcionamento e da cobertura do PNSVA. Trata-se de um estudo transversal, realizado em Uberlândia, Minas Gerais, para o qual foram realizadas entrevistas com os profissionais de 58 Unidades Básicas de Saúde (UBS). Os dados da cobertura do PNSVA (2012 a 2020) foram coletados através do Sistema de Informação de Micronutrientes. Dos entrevistados, 39,6% citaram a distribuição de cápsulas de vitamina A como forma de atingir os objetivos do PNSVA, e apenas 36,2% receberam capacitação sobre o programa. Em relação à sua operacionalização, 56,9% relataram nunca terem faltado cápsulas de vitamina A na UBS, e 41,3% realizavam o registro das doses administradas no Mapa Diário de Administração de Vitamina A. Já sobre o funcionamento do programa, 61,1% o avaliaram como bom. A cobertura do PNSVA foi inferior à meta pactuada, tendo sido observadas lacunas no conhecimento, na operacionalização e no funcionamento do programa.
Impacto da preocupação de possível queda na mobilidade funcional durante a execução de atividades de dupla tarefa em idosos: um estudo transversal
Authors: Gomes Ianca Ferreira , Castro Rayane Quintão , Da Rocha Daiane Lopes , Souza Gabriela Maria Auxiliadora Candido , Antunes Gisele Ladik , Contenças Thaís Santos
Published: April 2024

Introdução: O desempenho da marcha é um fator desafiador para os idosos que apresentam medo de queda, principalmente quando é preciso desempenhar a marcha e realizar outras tarefas simultaneamente. Objetivo: Analisar e comparar a mobilidade funcional de idosos com baixa e com alta preocupação em cair durante execução de tarefa simples e de dupla tarefa. Materiais e Métodos: Trata-se de um estudo transversal em que foram avaliados 24 idosos da comunidade. Inicialmente, aplicou-se a escala Falls Efficacy Scale – International (FES-I) e, então, os participantes foram divididos em dois grupos, um composto por idosos com baixa preocupação em cair (G1) e outro por idosos com alta preocupação em cair (G2). Em seguida, a mobilidade funcional dos participantes foi avaliada por meio do teste Timed Up and Go (TUG) convencional e associado à dupla tarefa. Também foi aplicada a escala de Downton para quantificar o risco de quedas dos idosos. Resultados: Os grupos apresentaram diferença na tarefa de TUG convencional (G1: 10,03 ± 1,43 segundos; G2: 11,35 ± 1,79 segundos), embora não tenha apresentado significância estatística (p= 0,058).  Houve diferença significativa entre os grupos no TUG dupla tarefa motora-cognitiva (G1: 11,69 ± 2,80 segundos; G2: 16,01 ± 3,91 segundos; p= 0,005) e na dupla tarefa motora-motora (G1: 10,19 ± 1,07 segundos; G2: 11,88 ± 2,48 segundos; p= 0,041). Conclusão: Idosos com preocupação em cair apresentam redução da mobilidade funcional em atividades de dupla tarefa, quando comparados com idosos que não apresentam preocupação em cair.
Prospecção fitoquímica e avaliação das atividades antimicrobiana e antioxidante de espécies de Arecaceae
Authors: Fabri Rodrigo Luiz , de Oliveira Lemos Ari Sérgio , De Lima Paula Priscila de Lima Paula , De Freitas Souza Thalita , Gomes Ferreira Thayná , Melo Campos Lara , Torres Branca Matheus
Published: April 2024

Introdução: A incidência de microrganismos resistentes a terapias convencionais desperta a necessidade no desenvolvimento de novos antimicrobianos.  Além disso, o dano celular gerado em decorrência da produção de radicais livres na presença de patógenos também configura um fator importante para a busca de novos compostos bioativos. Objetivo: Avaliar as atividades antioxidante e antimicrobiana dos extratos etanólicos das folhas de Bactris gasipaes Kunth (BGFoEt), folhas de Manicaria saccifera Gaertn. (MSFoEt), frutos e raízes de Mauritia flexuosa L.f. (MFFrEt e MFREt), sementes de Ptychosperma pullenii Essig (PPSEt), polpa de Raphia vinífera P. Beauv. (RVPoEt), frutos de Syagrusschizophylla (Mart.) Glassman (SSFrEt) e do extrato aquoso de frutos de Areca catechu L. (ACFrAq). Materiais e Métodos: Foram realizadas análises fitoquímicas, determinação do teor de flavonoides, determinação do potencial antioxidante, através de redução do complexo fosfomolibdênio, redução do radical DPPH e inibição do sistema β-caroteno/ácido linoleico, e atividade antimicrobiana, através da determinação da concentração inibitória mínima (CIM). Resultados: A prospecção fitoquímica revelou a presença de alcalóides, cumarinas, taninos, triterpenos, esteroides, flavonoides e antraquinonas. O teor de flavonoides totais variou entre 17,9 e 76,2 mg/g equivalentes à rutina. Os extratos MSFoEt, RVPoEt, PPSEt e MFREt apresentaram resultados significativos para redução do complexo fosfomolibdênio (83±0,3; 106±1,8; 25±1,6 e 29±4,5 % da atividade antioxidante relativa à quercetina, respectivamente) e inibição do radical DPPH (CE50 de 1,0±0,2; 1,7±0,2; 8,4±0,7 e 3,8±0,3 μg/mL, respectivamente). Para estes extratos realizou-se o método β-caroteno/ácido linoleico, com porcentagem de inibição da oxidação de 49,0±2,6; 41,4±0,6; 45,0±1,9 e 51,4±1,7 %, respectivamente.  Conclusão: Neste trabalho foram identificados extratos de espécies da família Arecaceae com significativa atividade antioxidante e antimicrobiana com destaque para a espécie M. flexuosa. As atividades apresentadas podem estar relacionadas aos metabólitos encontrados nos extratos, principalmente os flavonoides. No entanto, mais estudos são necessários para compreender os resultados encontrados.
Panorama do ensino das práticas integrativas e complementares nos cursos de graduação em Odontologia no Sudeste brasileiro
Authors: Ferreira Luiz Miguel , Corrêa dos Santos Marcela , Souza Silva Matheus , Lamim Fuhrmann Maria Fernanda , Gonçalves Leite Isabel Cristina , Prado Elias Gracieli
Published: April 2024

Introdução: As práticas integrativas e complementares em saúde são o presente e o futuro dentro do Sistema Único de Saúde, especialmente na Atenção Básica. Além disso, é uma modalidade que investe em prevenção e promoção à saúde, evitando ou minimizando, portanto, o adoecimento do paciente. Objetivo: Avaliar a oferta do conteúdo das práticas integrativas e complementares nas disciplinas dos cursos de Odontologia das instituições de ensino superior no Sudeste do Brasil. Métodos: Realizou-se um estudo transversal utilizando as grades curriculares dos cursos, buscando informações referentes às variáveis: categoria administrativa das instituições (pública ou privada); oferta da disciplina; natureza do componente curricular (obrigatória ou optativa); metodologia de ensino (teórico ou teórico-prática); e carga horária total. Resultados: A amostra da pesquisa foi composta por 180 faculdades, sendo 10 localizadas no estado de Espírito Santo, 71 em Minas Gerais, 25 no Rio de Janeiro e 74 em São Paulo. Em relação à categoria administrativa das instituições, 13,9% são públicas e 86,1% privadas. Apenas 11,1% dos cursos ofertam a disciplina de terapias complementares. Quando presente, a disciplina é predominantemente optativa e quanto à metodologia de ensino, destaca-se o enfoque somente teórico. Há diferença estatisticamente significativa (p<0,001) entre a oferta da disciplina e a categoria administrativa das instituições. A média das cargas horárias, apresentou o valor de 46,3 (±10,6) horas, não havendo diferença significativa entre as cargas horárias avaliadas segundo a natureza administrativa. Ainda, a homeopatia foi a terapia alternativa identificada com maior frequência nas matrizes curriculares. Conclusão: A maioria das instituições de ensino superior do Sudeste brasileiro não oferece nenhuma disciplina que aborde as práticas integrativas e complementares, tanto em aspecto geral quanto em caráter específico, e, quando ofertada, a disciplina tende a ser optativa e teórica.
Mortalidade por câncer de boca e faringe no Brasil entre 2008 e 2019: estudo descritivo
Authors: Campos Dell'Orto Zeferino , Ribondi Marcarini Gustavo Alexandre , Ferreira Costa Maria Vithória , Dias Lopes Paula Gabrielle , De Souza Queiroga Aline , De Freitas Espeschit Isis
Published: April 2024

Introdução: O câncer de boca e faringe tem etiologia multifatorial e representa cerca de 3% de todos os casos de câncer no mundo, sendo o quinto tipo mais prevalente em homens brasileiros. Objetivo: Analisar a mortalidade por câncer de boca e faringe ocorrida no Brasil e suas regiões no período de 2008 a 2019. Material e Métodos: Os dados foram extraídos no Sistema de Informações sobre Mortalidade (SIM) e no Instituto Brasileiro de Geografia e Estatística (IBGE). Foi conduzida uma análise descritiva das taxas de mortalidade global por sexo, raça, faixa etária, estado civil, escolaridade e sítio anatômico, com subsequente análise estatística por meio da tendência temporal por regressão linear simples. Resultados: No período, houve o crescimento de 33,25% dos óbitos, taxa de mortalidade média de 3,64/100 mil habitantes e a análise de tendência temporal demonstrou aumento anual de 0,06 óbitos para cada cem mil habitantes. Ademais, pode-se observar mais frequentes óbitos no Sudeste 49,28%, nas faixas etárias de 50 a 79 anos com 73,31%, em pessoas casadas, 41,19%, na raça branca, 53,49%, com escolaridade de 1 a 3 anos, 25,73% e sexo masculino, 78,97%. Nesses, obteve-se a razão das taxas de mortalidade masculina e feminina de 3,75 e taxa de mortalidade masculina crescente, com uma taxa média de 5,83, sendo a feminina de 1,51 cem mil habitantes. Conclusão: O perfil de mortalidade do estudo por câncer de boca e orofaringe é predominantemente composto por indivíduos do sexo masculino, brancos, de 50 a 69 anos, casados e de baixa escolaridade. Embora mais frequente nas regiões Sul e Sudeste, as taxas de mortalidade apresentam uma tendência de crescimento anual, em especial na região Nordeste do país.
Relação entre ferro e folato dietético e a qualidade da dieta materna
Authors: Ferreira de Castro Ana Luiza , Morais de Moura Lahis Cristina , Dos Santos Pinto Roberta , Lima de Oliveira João Paulo , Ferreira Fróis Laudicéia , Martins dos Santos Chagas Carolina , Castro Crivellenti Lívia , Gonçalves Teixeira Lílian
Published: April 2024

Introdução: Durante a gestação, são inúmeras as mudanças que permeiam a vida da mulher. Desta forma é fundamental conhecer os hábitos e padrões de consumo alimentar, a fim de elaborar estratégias que elucidem o cuidado e atenção de forma integrativa no período gestacional. Objetivo: Avaliar a correlação entre ingestão materna de ferro e folato dietético e o Índice de Qualidade da Dieta Adaptado para Gestantes (IQDAG). Métodos: Estudo transversal conduzido com 198 gestantes adultas atendidas no município de Lavras - MG.  Foram coletadas informações sociodemográficas através de um questionário estruturado, e os dados obstétricos e antropométricos foram obtidos do cartão de pré-natal das gestantes. O consumo alimentar foi estimado por meio do relato de um dia habitual da dieta e a qualidade da dieta foi avaliada empregando-se o IQDAG. Utilizou-se o teste estatístico Kruskal-Wallis para comparação de características sociodemográficas, obstétricas e antropométricas, como também para a comparação dos valores médios de ingestão de ferro e folato dietético nos diferentes tercis do IQDAG. Resultados: A média de idade das gestantes foi de 27 anos±5,98. A maioria das mulheres apresentavam ensino médio completo (48,5%); renda familiar entre 1 e 2 salários mínimos (49,5%); não planejaram a gestação (62,6%) e era multípara (55,3%). O valor de pontuação média do IQDAG foi de 62,32±13,97. Gestantes com maior ingestão de ferro e folato apresentaram maior pontuação do IQDAG (melhor qualidade da dieta) (r= 0,31; p<0,001; r= 0,33; p<0,001, respectivamente), mesmo sem o uso da suplementação. Conclusões:  O IQDAG pode ser considerado uma ferramenta útil na avaliação da qualidade da dieta de gestantes, independente do uso de suplementos de ferro e folato, pois a ingestão dietética desses nutrientes foi positivamente correlacionada à qualidade da dieta.
Avaliação e correlação da qualidade de vida e necessidades espirituais de pacientes oncológicos com doença avançada em vigência de internação hospitalar
Authors: Martin da Silva Gabriel , De Fátima Canquerini Elizangela , Castiglione Mariane , Cristina Biagi Alessandra , Estevão da Silva Amanda
Published: April 2024

Introdução: A doença gera no ser humano um processo profundo de angústia, tristeza  e sofrimento manifestando-se em diversas áreas da vida, levantando questões emocionais, físicas, sociais e espirituais. Objetivo: Avaliar e correlacionar a qualidade de vida e necessidades espirituais de pacientes oncológicos em vigência de internação hospitalar. Método: Estudo observacional, transversal e prospectivo, aprovado pelo comitê de ética e pesquisa do  Centro Universitário FMABC sob número de parecer: 3.850.192. Os participantes foram selecionados e posteriormente entrevistados individualmente por meio dos questionários Spiritual Needs Assessment for Patients (SNAP) e o Short Form-36 (SF- 36), além de dados sociodemográficos. Para correlacionar a qualidade de vida (SF-36) com as necessidades espirituais (SNAP), utilizou-se o teste de Correlação de Spearman. O nível de significância adotado foi de 5%. Resultados: Participaram do estudo 31 pacientes, com diagnóstico de doença oncológica confirmado e em vigência de internação hospitalar. Os piores escores na avaliação da qualidade de vida foram os domínios de “aspecto físico”, “aspecto emocional” e “capacidade funcional”. Observou-se alta necessidade espiritual com pontuação total de 74,35 no SNAP. Na correlação entre o SF-36 e o SNAP observou-se correlações negativas com relevância estatisticamente significativa entre o domínio de capacidade funcional e a subescala psicossocial (-0,387), domínio de dor e subescala espiritual (-0,316) e domínio de aspecto físico e subescala religiosa (-0,351). Conclusão: Pacientes oncológicos em vigência de internação hospitalar têm prejuízo na qualidade de vida, apresentam necessidades espirituais, e essas variáveis podem influenciar-se entre si. Portanto, a equipe multiprofissional deve estar atenta à dimensão espiritual do paciente.