bluuebunny/crossref_metadata_2025 huggingface dataset:
Wideband parametric baseband macromodeling of linear and passive photonic circuits via complex vector fitting
Authors: Ullrick Thijs , Spina Domenico , Bogaerts Wim , Dhaene Tom
Published: September 2023

A novel wideband parametric baseband macromodeling technique for passive photonic devices and circuits is presented. It allows to efficiently estimate the baseband scattering representations of a linear, passive photonic system as a function of a set of design variables, such as geometrical layout or substrate features. The proposed technique relies on the interpolation of macromodels computed via a complex vector fitting (CVF) algorithm, by adopting a methodology based on amplitude and frequency scaling that preserves, by construction, the physical properties of the system, such as causality, stability and passivity. For a specified combination of the design parameters, a rational CVF model is derived that can be simulated by a wide range of ordinary differential equation (ODE) solvers or circuit simulators. Additionally, time-domain simulations using the computed model can be performed at arbitrary optical carrier frequencies, thus allowing for the simulation of multi-wavelength systems. Two application examples are presented to demonstrate the flexibility and advantages of the proposed method.
Green synthesis of TiO2 for furfural production by photohydrolysis of tortilla manufacturing waste
Authors: López-Mercado Janneth , González-Domínguez Martha-Isabel , Reynoso-Marin Francisco-Javier , Acosta Brenda , Smolentseva Elena , Nambo Apolo
Published: September 2023

Corn nixtamalization generates a waste byproduct that requires diverse environmental preservation measures depending on the country. Such measures could include catalytic and advanced oxidation processes. This study aims to exploit the hemicellulose within the nejayote (32.5%) to create added value chemicals such as furfural using photocatalytic hydrolysis. In the present work, titania (TiO2) nanoparticles (NPs) were greenly synthesized using Ricinus Communis (RC), Moringa Oleifera (MO) or Bougainvillea Spectabilis (BS) plant extracts. Obtained nanoparticles were characterized using XRD, SEM, EDS, BET, XPS and UV–vis techniques. Furthermore, the photocatalytic performance of the obtained samples was evaluated in the furfural production from nejayote. Furfural yield reached 44% in 30 min using the BS synthesized material, which is 1.6 × the yield obtained by the material synthesized with MO extract (26.4% at 45 min) and 6 × the yield obtained by the material obtained with RC (7.2% at 90 min). Such results have not been reported before in the literature and could be the groundwork for novel waste treatments in the tortilla-making industry.
A new hybrid algorithm for intelligent detection of sudden decline syndrome of date palm disease
Authors: Magsi Aurangzeb , Mahar Javed Ahmed , Maitlo Abdullah , Ahmad Muneer , Razzaq Mirza Abdur , Bhuiyan Mohammad Arif Sobhan , Yew Teh Jia
Published: September 2023

Date palm is an important domestic cash crop in most countries. Sudden Decline Syndrome (SDS) causes a huge loss to the crop both in quality and quantity. The literature reports the significance of early detection of disease towards preventive measures to improve the quality of the crop. The number of prevailing detection methods limits to consideration of a certain aspect of disease identification. This study proposes a new hybrid fuzzy fast multi-Otsu K-Means (FFMKO) algorithm integrating the date palm image enhancement, robust thresholding, and optimal clustering for significant disease identification. The algorithm adopts a multi-operator image resizing cost function based on image energy and the dominant color descriptor, the adaptive Fuzzy noise filter, and Otsu image thresholding combined with K-Means clustering enhancements. Besides, we validate the process with histogram equalization and threshold transformation towards enhanced color feature extraction of date palm images. The algorithm authenticates findings on a local dataset of 3293 date palm images and, on a benchmarked data set as well. It achieves an accuracy of 94.175% for successful detection of SDS that outperforms the existing similar algorithms. The impactful findings of this study assure the fast and authentic detection of the disease at an earlier stage to uplift the quality and quantity of the date palm and boost the agriculture-based economy.
Implementation of large-scale pooled testing to increase rapid molecular diagnostic test coverage for tuberculosis: a retrospective evaluation
Authors: Vuchas Comfort , Teyim Pride , Dang Beh Frankline , Neh Angela , Keugni Liliane , Che Mercy , Che Pantalius Nji , Beloko Hamada , Fondoh Victor , Ndi Norah Nyah , Wandji Irene Adeline Goupeyou , Fundoh Mercy , Manga Henri , Mbuli Cyrille , Creswell Jacob , Bisso Annie , Donkeng Valerie , Sander Melissa
Published: September 2023

In 2021, only 6.4 million of the 10.6 million people with tuberculosis (TB) were diagnosed and treated for the disease. Although the World Health Organization recommends initial diagnostic testing using a rapid sensitive molecular assay, only 38% of people diagnosed with TB benefited from these, due to barriers including the high cost of available assays. Pooled testing has been used as an approach to increase testing efficiency in many resource-constrained situations, such as the COVID-19 pandemic, but it has not yet been widely adopted for TB diagnostic testing. Here we report a retrospective analysis of routine pooled testing of 10,117 sputum specimens using the Xpert MTB/RIF and Xpert MTB/RIF Ultra assays that was performed from July 2020 to February 2022. Pooled testing saved 48% of assays and enabled rapid molecular testing for 4156 additional people as compared to individual testing, with 6.6% of specimens positive for TB. From an in silico analysis, the positive percent agreement of pooled testing in pools of 3 as compared with individual testing for the Xpert MTB/RIF Ultra assay was estimated as 99.4% (95% CI, 96.6% to 100%). These results support the scale-up of pooled testing for efficient TB diagnosis.
Cross-hemispheric recruitment during action planning with increasing task demand
Authors: Schach Sonja , Braun Daniel Alexander , Lindner Axel
Published: September 2023

The recruitment of cross-hemispheric counterparts of lateralized prefrontal brain regions with increasing processing demand is thought to increase memory performance despite cognitive aging, but was recently reported to be present also in young adults working at their capacity limit. Here we ask if cross-hemispheric recruitment is a general strategy of the adult brain in that executive task demand would modulate bilateral activation beyond prefrontal cortex and across cognitive tasks. We analyzed data sets from two fMRI experiments investigating retrospective working memory maintenance and prospective action planning. We confirmed a cross-hemispheric recruitment of prefrontal cortex across tasks and experiments. Changes in lateralization due to planning further surfaced in the cerebellum, dorsal premotor and posterior parietal cortex. Parietal cortex thereby exhibited cross-hemispheric recruitment also during spatial but not verbal working memory maintenance. Our results confirm a domain-general role of prefrontal cortex in cross-hemispheric recruitment. They further suggest that other task-specific brain regions also recruit their idling cross-hemispheric counterparts to relocate executive processing power.
Near-field projection optical microscope (NPOM) as a new approach to nanoscale super-resolved imaging
Authors: Sanjeev Abhijit , Glukhov David , Salahudeen Rafeeka Rinsa , Karsenty Avi , Zalevsky Zeev
Published: September 2023

A new super-resolution method, entitled Near-field Projection Optical Microscopy (NPOM), is presented. This novel technique enables the imaging of nanoscale objects without the need for surface scanning, as is usually required in existing methods such as NSOM (near-field scanning optical microscope). The main advantage of the proposed concept, besides the elimination of the need for a mechanical scanning mechanism, is that the full field of regard/view is imaged simultaneously and not point-by-point as in scanning-based techniques. Furthermore, by using compressed sensing, the number of projected patterns needed to decompose the spatial information of the inspected object can be made smaller than the obtainable points of spatial resolution. In addition to the development of mathematical formalism, this paper presents the results of a series of complementary numerical tests, using various objects and patterns, that were performed to verify the accuracy of the reconstruction capabilities. We have also performed a proof of concept experiment to support the numerical formalism.
Regulation of psoriasis, colitis, and the intestinal microbiota by clusterin
Authors: Jun Yu Kyung , Yoon Hee Tae , Kwon So Hyun , Jo Ui Hyeon , Kim Ji Eun , Han Yoo Min , Kim Min-Seon , Im Jong Pil , Lee Dong Ho , Kim Joo Sung , Koh Seong-Joon , Park Hyunsun
Published: September 2023

Psoriasis, a chronic and systemic inflammatory disorder characterized by activation of the interleukin (IL)-23/IL-17 axis, may be associated with the intestinal microbiota through the so-called “gut–skin axis.” Clusterin is a glycoprotein ubiquitously distributed in mammalian tissues; however, its role in psoriasis is unclear. Therefore, we evaluated the role of clusterin in psoriatic skin inflammation, systemic inflammation, and colitis using a murine model of IMQ-induced psoriasis. In IMQ-treated clusterin-knockout (clusterin−/−) mice, the expressions of inflammatory cytokines in clusterin-silenced human keratinocytes and intestinal microbial composition were analyzed. We also examined clusterin expression in the skin tissues of patients with psoriasis. IMQ-induced psoriatic skin inflammation is suppressed in clusterin−/− mice. Long-term administration of IMQ induced systemic inflammation and colitis; however, both were alleviated by the genetic deletion of clusterin. Genetic silencing of clusterin in human keratinocytes inhibited the production of inflammatory cytokines involved in the initiation and progression of psoriasis. The composition of the intestinal microbiota in IMQ-treated clusterin−/− and wild-type mice was different. Genetic deletion of clusterin suppressed the increase in the Firmicutes/Bacteroidetes (F/B) ratio. Skin tissues of patients with psoriasis showed high clusterin expression. In conclusion, inhibition of clusterin decreased psoriatic skin inflammation, systemic inflammation, colitis, and altered the F/B ratio in an IMQ-induced murine psoriasis model.
Authentication of protein, fat, carbohydrates, and total energy in commercialized high protein sports foods with their labeling data
Authors: Aly Maged Ossama , Ghobashy Somia Mohamed , Aborhyem Samar Mohamed
Published: September 2023

The popularity of high-protein sports food items among athletes and the bodybuilding community has risen dramatically. This study aimed to authenticate the reported per serving food label content of protein, fat, carbohydrate, and total energy in commercially available high-protein sports foods available in Egyptian markets. A cross-sectional study was performed on a total of forty-five samples of nine products that included protein bars, cookies, vegan bars, puffs, whey protein, protein drinks, peanut butter, pancake mix, and Greek yogurt. Protein and fat analysis were done according to Kheldahl and Folich methods, respectively, while carbohydrate was calculated by difference. Total energy was calculated according to their content. A significant (p < 0.001) difference was found between the laboratory-assessed content and the reported food label values in protein, carbohydrate, and energy. Protein sport food products had significantly lower protein content (11.6 ± 4.67) obtained from laboratory measurement than the label reported value (17.17 ± 7.22). The fat content in vegan protein was 149.3% higher than the label values (1.67 vs. 0.67 g/serving). The mean fat content per serving of 30 out of 45 samples was significantly higher than the food label values in the bar (37.8%), puffs (32.7%), vegan protein (149.3%), and protein drinks (28.6%). These differences may result in compromised performance and undesired fat gain, as opposed to a desired increase in muscle mass, which could compromise the desired impact of the consumed sports foods.
Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis
Authors: van Alen Ilona , Aguirre García Mayra A. , Maaskant Janneke J. , Kuijl Coenraad P. , Bitter Wilbert , Meijer Annemarie H. , Ubbink Marcellus
Published: September 2023

The β-lactamase of Mycobacterium tuberculosis, BlaC, hydrolyzes β-lactam antibiotics, hindering the use of these antibiotics for the treatment of tuberculosis. Inhibitors, such as avibactam, can reversibly inhibit the enzyme, allowing for the development of combination therapies using both antibiotic and inhibitor. However, laboratory evolution studies using Escherichia coli resulted in the discovery of single amino acid variants of BlaC that reduce the sensitivity for inhibitors or show higher catalytic efficiency against antibiotics. Here, we tested these BlaC variants under more physiological conditions using the M. marinum infection model of zebrafish, which recapitulates hallmark features of tuberculosis, including the intracellular persistence of mycobacteria in macrophages and the induction of granuloma formation. To this end, the M. tuberculosis blaC gene was integrated into the chromosome of a blaC frameshift mutant of M. marinum. Subsequently, the resulting strains were used to infect zebrafish embryos in order to test the combinatorial effect of ampicillin and avibactam. The results show that embryos infected with an M. marinum strain producing BlaC show lower infection levels after treatment than untreated embryos. Additionally, BlaC K234R showed higher infection levels after treatment than those infected with bacteria producing the wild-type enzyme, demonstrating that the zebrafish host is less sensitive to the combinatorial therapy of β-lactam antibiotic and inhibitor. These findings are of interest for future development of combination therapies to treat tuberculosis.
Calcination and ion substitution improve physicochemical and biological properties of nanohydroxyapatite for bone tissue engineering applications
Authors: Kurzyk Agata , Szwed-Georgiou Aleksandra , Pagacz Joanna , Antosik Agnieszka , Tymowicz-Grzyb Paulina , Gerle Anna , Szterner Piotr , Włodarczyk Marcin , Płociński Przemysław , Urbaniak Mateusz M. , Rudnicka Karolina , Biernat Monika
Published: September 2023

Nanohydroxyapatite (nanoHAP) is widely used in bone regeneration, but there is a need to enhance its properties to provide stimuli for cell commitment and osteoconduction. This study examines the effect of calcination at 1200 °C on the physicochemical and biological properties of nanoHAP doped with magnesium (Mg2+), strontium (Sr2+), and zinc (Zn2+). A synergistic effect of dual modification on nanoHAP biological properties was investigated. The materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), BET analysis, Fourier-transform spectroscopy, and thermal analysis methods. Furthermore, ion release tests and in vitro biological characterization, including cytocompatibility, reactive oxygen species production, osteoconductive potential and cell proliferation, were performed. The XRD results indicate that the ion substitution of nanoHAP has no effect on the apatite structure, and after calcination, β-tricalcium phosphate (β-TCP) is formed as an additional phase. SEM analysis showed that calcination induces the agglomeration of particles and changes in surface morphology. A decrease in the specific surface area and in the ion release rate was observed. Combining calcination and nanoHAP ion modification is beneficial for cell proliferation and osteoblast response and provide additional stimuli for cell commitment in bone regeneration.
Radiological assessment of different monazite grades after mechanical separation from black sand
Authors: kotb N. A. , Abd El Ghany M. S. , El-sayed Ashraf A.
Published: September 2023

In Egyptian black sands, monazite is a precious mineral characterized by its composition, which includes crucial constituents such as thorium, trace amounts of uranium, and rare earth elements. It is essential to evaluate and quantify the extent of gamma-ray exposure resulting from the presence of primordial radionuclides. This necessity arises from human activities that extract and retrieve raw materials in uranium and thorium mining operations. The current study focuses on the radiological assessment of Monazite raw material in various grades and calculates the associated hazard indices. A hyper pure Germanium detector (HPGe) determined the particular activity. For grade, 90% Monazite samples, the average activities for 232Th, 238U, and 40K were 348,008 ± 1406, 69,299 ± 2086, and 27,510 ± 245 Bq/kg, respectively. For grade 75% Monazite samples, the average activities were 219,000 ± 901, 55,000 ± 500, and 18,300 ± 86 Bq/kg, while for grade 50% Monazite samples, it was 43,294 ± 1549, 9593 ± 629, and 4000 ± 211 Bq/kg for the same element, respectively. Also, 138La’s inherent radioactivity was taken into account. The computed effective and absorbed dosages exceed the worker’s exempt limit of 20 mSv/y. The calculated hazard parameters are higher than the maximum recommended limits. Therefore, it is imperative to employ radiation safety measures to mitigate the potential hazards of ionizing radiation.
Molecular characterization of Vibrio species isolated from dairy and water samples
Authors: El-Zamkan Mona A. , Ahmed Ahmed Shaban , Abdelhafeez Hanan H. , Mohamed Hams M. A.
Published: September 2023

Vibrio species can cause foodborne infections and lead to serious gastrointestinal illnesses. The purpose of this research was to detect the Vibrio cholerae and Vibrio parahaemolyticus in raw milk, dairy products, and water samples. Also, it investigated the virulence factors, antibiotic resistance and biofilm formation in isolated bacteria. Conventional and molecular approaches were used to identify the isolates in this study. Vibrio species were detected in 5% of the samples. Vibrio cholerae and Vibrio parahaemolyticus were isolated from 1.25 and 1.5%, respectively, of the total samples. Penicillin resistance was detected in all strains of Vibrio cholerae and Vibrio parahaemolyticus, with a MAR index ranging from 0.16 to 0.5. Four isolates were moderate biofilm producer and three of them were MDR. When Vibrio cholerae was screened for virulence genes, ctxAB, hlyA, and tcpA were found in 80, 60, and 80% of isolates, respectively. However, tdh + /trh + associated-virulence genes were found in 33.3% of Vibrio parahaemolyticus isolates.
Correlate the cyanogenic potential and dry matter content of cassava roots and leaves grown in different environments
Authors: Alamu Emmanuel Oladeji , Dixon Gilbert Alfred , Adesokan Michael , Maziya-Dixon Busie
Published: September 2023

Cassava (Manihot esculenta Crantz) is an essential stable food crop in Sub-Saharan Africa commonly consumed amongst the low-income communities in Africa. Though cassava roots and leaf have vast economic and commercial benefits, it produces cyanogenic glycosides, which are toxic and most often responsible for the bitter taste of some cassava cultivars. The study evaluates the cassava roots and leaves’ cyanogenic potential and dry matter content of the Genetic Gain Assessment trial grown in a different environment. It establishes the association between the cyanogenic potential (CNP) and the roots and leaves dry matter (DM). Genetic Gain Assessment (GGA) cassava genotypes (N = 400) selected for the Uniform Yield Trial (UYT) breeding stage were planted under IVS (Dry season in Inland Valley Hydromorphic area) and Upland (rain-fed conditions) in two locations of IITA Research Farms, namely; Ibadan (IVS and Upland) and Mokwa (Upland) in Nigeria. The CNP content of cassava leaves in IVS, Mokwa, and Upland ranged from 3.39 to 272.16 mg/100 g, 4.28 to 228.72 mg/100 g, and 13.13 to 127.39 mg/100 g, respectively. However, the respective CNP range in root samples across IVS, Mokwa, and Upland was 0.76–76.31 mg/100 g, 0.94–136.53 mg/100 g, and 2.37–47.11 mg/100 g. Also, the mean ± SD of DM content of leaves were 27.97 ± 3.01%, 28.81 ± 4.01%, and 13.65 ± 3.69%, respectively, in IVS, Mokwa, and Upland, while the root samples had mean ± SD of DM content of 38.09 ± 4.80%, 32.69 ± ,5.93% and 24.63 ± 5.07% respectively. Furthermore, location and genotype had a highly significant effect (p < 0.001) on the CNP and DM of roots and leaves. Also, linear regressions were established between CNP and DM of root and leaf with regression equation; DM-Root = 1.1999*DM-Leaf (r = 0.956) and CNP-Root = 0.29006*CNP-Leaf (r = 0.54). The relationship between the DM (root and leaf) and CNP (root and leaf) could serve as a valuable “inter-prediction” tool for these parameters.
Optimal system and dynamics of optical soliton solutions for the Schamel KdV equation
Authors: Hussain A. , Chahlaoui Younes , Usman M. , Zaman F. D. , Park Choonkil
Published: September 2023

In this research, we investigate the integrability properties of the Schamel–Korteweg–de Vries (S-KdV) equation, which is important for understanding the effect of electron trapping in the nonlinear interaction of ion-acoustic waves. Using the optimal system, we come over reduced ordinary differential equations (ODEs). To deal with reduced ODEs for this problem, Lie symmetry analysis is combined with the modified auxiliary equation (MAE) procedure and the generalized Jacobi elliptic function expansion (JEF) method. The analytical solutions reported here are novel and have a wide range of applications in mathematical physics.
Organic walled microfossils in wet peperites from the early Cretaceous Paraná-Etendeka volcanism of Brazil
Authors: Del Mouro Lucas , Becker-Kerber Bruno , Janasi Valdecir A. , de Araújo Carvalho Marcelo , Waichel Breno L. , Lima Evandro F. , Rossetti Lucas M. M. , Cruz Vinicius , Silva Mateus Souza , Famelli Natália , Ortega-Hernández Javier
Published: September 2023

Large igneous provinces (LIPs) are major magmatic events that have a significant impact on the global environment and the biosphere, for example as triggers of mass extinctions. LIPs provide an excellent sedimentological and geochemical record of short but intense periods of geological activity in the past, but their contribution towards understanding ancient life is much more restricted due to the destructive nature of their igneous origin. Here, we provide the first paleontological evidence for organic walled microfossils extracted from wet peperites from the Early Cretaceous Paraná-Etendeka intertrappean deposits of the Paraná basin in Brazil. Wet peperites are a volcaniclastic rock formed by the interaction of lava and subaqueous sediments.The Paraná-Etendeka was formed during the Valanginian (ca. 132 Ma) as a continental flood basalt in present day South America and Namibia, and released enormous amounts of carbon dioxide, sulfur dioxide, methane and hydrogen fluoride into the atmosphere. The organic walled microfossils recovered from the Paraná-Etendeka peperites include pollen grains, spores, acritarchs, and other remains of unidentifiable organic matter. In addition to the peperites, organic walled microfossils were also found in heterolithic sandstones and interpillow sandstones. Our findings represent the first insight into the biodiversity of the Paraná Basin during the Early Cretaceous during a period of intense magmatism, and the microfossil assemblages corroborate a regional paleoclimatic transition from arid to more humid conditions that were likely induced by the volcanic activity. We corroborate the potential of wet peperite rocks as a valuable source of paleobiological data and emphasize the importance of sampling volcaniclastic units that have been traditionally considered with lower fossiliferous potential due to their igneous origin.
Effect of the macular shape on hole findings in idiopathic macular hole differs depending on the stage of the macular hole
Authors: Terasaki Hiroto , Yamashita Toshifumi , Funatsu Ryoh , Nomoto Shohei , Fujiwara Kazuki , Shiihara Hideki , Yamashita Takehiro , Sakamoto Taiji
Published: September 2023

This study aimed to investigate the relationship between macular shape and idiopathic macular hole (MH) findings using an objective method. We present retrospective observational case series on patients with MH. The shape of the macular area was quantified using quadratic equations, and the ocular shape (OS) index was calculated. The correlation between the OS index and macular hole findings for each stage was evaluated. Pearson's correlation coefficient showed a significant correlation between the OS index and horizontal hole diameter (p = 0.044), bottom diameter (p = 0.006), and vertical bottom diameter (p = 0.024) in stage 2. For stage 4, there was a negative and significant correlation between the OS index and age (p = 0.037), and horizontal (p = 0.021) and vertical (p = 0.027) bottom diameter. Multiple regression analysis showed that the horizontal (p = 0.0070) and vertical (p = 0.031) bottom diameter and OS index were independently and positively correlated in stage 2. In stage 4, the OS index was independently and negatively correlated with the horizontal (p = 0.037) and vertical (p = 0.048) bottom diameter. The ocular shape of the macula affects MH findings, and its impact depends on its stage.
Enhancement of Doppler spectroscopy to transverse direction by using optical vortex
Authors: Minagawa Hiroki , Yoshimura Shinji , Terasaka Kenichiro , Aramaki Mitsutoshi
Published: September 2023

Tunable diode laser absorption spectroscopy (TDLAS) is a valuable method for measuring particle flow velocities in plasma. However, conventional TDLAS using a plane-wave beam is sensitive only to the laser propagation direction. This limitation is particularly unfavorable for the observation of the particle transportation perpendicularly incident on the material in the plasma–material interaction. In this paper, we show for the first time that flow measurements perpendicular to the beam direction are possible by replacing the probe beam with an optical vortex beam. Because an optical vortex has a helical wavefront, particles moving in its field experience an azimuthal Doppler shift in addition to the translational Doppler shift. Assuming a uniform gas flow across the optical vortex, the azimuthal Doppler shift of the absorption spectrum observed in the beam cross-section varies sinusoidally in the azimuthal direction. The transverse flow velocity is derived from the amplitude of this sinusoidal variation. At transverse velocities above 70 m/s, the measurement errors are found to be less than 15%, with a mean absolute percentage error of less than 8%.
Experimental study on the probabilities of kinked arches and kinked arch locations in ore passes under the influences of multiple factors
Authors: Ma Jiaoyang , Wei Dianen , Zhang Qingsong
Published: September 2023

A smooth shaft production process is important to ensure the safe and efficient development of mineral resources. Due to the influence of ore rock and the mismatch between rock size and ore pass design, an arching phenomenon occurs frequently during actual ore pass release, stagnating production. Therefore, an ore pass release simulator with a freely variable ore pass angle and height is designed and used to conduct a four-factor, five-level orthogonal ore pass release experiment. An analysis is performed to determine the influence of four factors—ore particle size, ore moisture, ore pass inclination and slip height—on the probability of ore pass arching; from there, an ore pass arching probability equation is constructed and the characteristics of the ore pass arching location are clarified, effectively predicting the probability of ore pass arching and providing an effective basis for handling arching events within an applicable range. This analysis effectively predicts the probability of ore pass arch within the applicable range, and provides an effective basis for handling ore pass arch events.
Predicting ecosystem changes by a new model of ecosystem evolution
Authors: Yoshida Katsuhiko , Hata Kenji , Kawakami Kazuto , Hiradate Syuntaro , Osawa Takeshi , Kachi Naoki
Published: September 2023

In recent years, computer simulation has been increasingly used to predict changes in actual ecosystems. In these studies, snapshots of ecosystems at certain points in time were instantly constructed without considering their evolutionary histories. However, it may not be possible to correctly predict future events unless their evolutionary processes are considered. In this study, we developed a new ecosystem model for reproducing the evolutionary process on an oceanic island, targeting Nakoudojima Island of the Ogasawara Islands. This model successfully reproduced the primitive ecosystem (the entire island covered with forest) prior to the invasion of alien species. Also, by adding multiple alien species to this ecosystem, we were able to reproduce temporal changes in the ecosystem of Nakoudojima Island after invasion of alien species. Then, we performed simulations in which feral goats were eradicated, as had actually been done on the island; these suggested that after the eradication of feral goats, forests were unlikely to be restored. In the ecosystems in which forests were not restored, arboreous plants with a high growth rate colonized during the early stage of evolution. As arboreous plants with a high growth rate consume a large amount of nutrient in soil, creating an oligotrophic state. As a result, plants cannot grow, and animal species that rely on plants cannot maintain their biomass. Consequently, many animals and plants become extinct as they cannot endure disturbances by alien species, and the ecosystem loses its resilience. Therefore, even if feral goats are eradicated, forests are not restored. Thus, the founder effect from the distant past influences future ecosystem changes. Our findings show that it is useful to consider the evolutionary process of an ecosystem in predicting its future events.
Systemic epigenome-wide association study of elk treponeme-associated hoof disease
Authors: Wild Margaret A. , Taylor Kyle R. , Nilsson Eric E. , Beck Daniel , Skinner Michael K.
Published: September 2023

Treponeme-associated hoof disease (TAHD) is an emerging disease of elk (Cervus canadensis) in the U.S. Pacific West. Because environmental epigenetics is the primary molecular process that mediates environmental factor impacts on a host organism and disease, the role of epigenetics in TAHD etiology was examined. The current study was designed to examine potential effects of TAHD on systemic epigenetic modifications in infected elk over a range of TAHD lesion severity. Leg tendons that contain predominantly fibroblast connective tissue cells were used to isolate fibroblast cells for epigenetic analysis in unaffected and TAHD-positive male and female Roosevelt and Rocky Mountain elk. Differential DNA methylation regions (DMRs) between the unaffected and TAHD-positive elk were identified for both female and male elk. The presence of TAHD was associated with alteration of the connective tissue cell epigenetics, and DMR associated genes identified. Therefore, the infected elk were found to have a systemic epigenetic alteration that was associated with the disease, despite pathology being generally limited to feet. If the elk germline epigenetics is altered then generational transmission of susceptibility to TAHD may impact subsequent generations through epigenetic inheritance. This first study of epigenetic changes associated with disease in elk suggests that TAHD promotes a systemic effect on the elk epigenetics which could exert health impacts on the elk.
Household catastrophic health expenditures for rheumatoid arthritis: a single centre study from South India
Authors: Bagepally Bhavani Shankara , Kumar S. Sajith , Sasidharan Akhil , Haridoss Madhumitha , Venkataraman Krishnamurthy
Published: September 2023

Rheumatoid arthritis (RA) not only has a physical and emotional toll but also has a substantial economic impact. This study aims to estimate the burden of catastrophic health expenditure (CHE) on households due to RA in Tamil Nadu, India. We conducted cross-sectional descriptive hospital-based single-centre study at a tertiary care private multispecialty hospital in Tamil Nadu, India. The study comprised 320 RA patients who visited the outpatient clinic from April to October 2022. Demographic and baseline descriptive characteristics were reported. Multivariable logistic regression analyses were performed to identify major determinants associated with CHE. We also examined the inequality in household annual income and CHE. Most study participants were females (88.1%) with a mean age (SD) of 55.57 ± 12.29 years. About 93% of RA patients were from urban areas, and 89.4% were literate. Only 8.1% of respondents reported having health insurance. Households experiencing CHE owing to RA were 51.4% (n = 162). The mean (95% CI) annual health expenditure for treating RA is ₹44,700 (₹41,710 to 47,690) with a median (IQR) of ₹39,210 (₹25,500) [$476 ($310)]. The corresponding mean (95% CI) and median (IQR) Out of pocket expenditure among RA patients per household were ₹40,698 (₹38,249 to 43,148) [$494 ($464 to $524)] and ₹36,450 (23,070) [$442 ($280)] respectively. Nearly half of the households with RA patients had a financial catastrophe due to healthcare costs being paid out-of-pocket and limited health insurance coverage. The results underscore the need for comprehensive approaches to strengthening public health policies along with financial risk protection and quality care in India.
Enhancing protein trapping efficiency of graphene oxide-polybutylene succinate nanofiber membrane via molecular imprinting
Authors: Sathirapongsasuti Nuankanya , Panaksri Anuchan , Jusain Benjabhorn , Boonyagul Sani , Pechprasarn Suejit , Jantanasakulwong Kittisak , Suksuwan Acharee , Thongkham Somprasong , Tanadchangsaeng Nuttapol
Published: September 2023

Filtration of biological liquids has been widely employed in biological, medical, and environmental investigations due to its convenience; many could be performed without energy and on-site, particularly protein separation. However, most available membranes are universal protein absorption or sub-fractionation due to molecule sizes or properties. SPMA, or syringe-push membrane absorption, is a quick and easy way to prepare biofluids for protein evaluation. The idea of initiating SPMA was to filter proteins from human urine for subsequent proteomic analysis. In our previous study, we developed nanofiber membranes made from polybutylene succinate (PBS) composed of graphene oxide (GO) for SPMA. In this study, we combined molecular imprinting with our developed PBS fiber membranes mixed with graphene oxide to improve protein capture selectivity in a lock-and-key fashion and thereby increase the efficacy of protein capture. As a model, we selected albumin from human serum (ABH), a clinically significant urine biomarker, for proteomic application. The nanofibrous membrane was generated utilizing the electrospinning technique with PBS/GO composite. The PBS/GO solution mixed with ABH was injected from a syringe and transformed into nanofibers by an electric voltage, which led the fibers to a rotating collector spinning for fiber collection. The imprinting process was carried out by removing the albumin protein template from the membrane through immersion of the membrane in a 60% acetonitrile solution for 4 h to generate a molecular imprint on the membrane. Protein trapping ability, high surface area, the potential for producing affinity with proteins, and molecular-level memory were all evaluated using the fabricated membrane morphology, protein binding capacity, and quantitative protein measurement. This study revealed that GO is a controlling factor, increasing electrical conductivity and reducing fiber sizes and membrane pore areas in PBS-GO-composites. On the other hand, the molecular imprinting did not influence membrane shape, nanofiber size, or density. Human albumin imprinted membrane could increase the PBS-GO membrane’s ABH binding capacity from 50 to 83%. It can be indicated that applying the imprinting technique in combination with the graphene oxide composite technique resulted in enhanced ABH binding capabilities than using either technique individually in membrane fabrication. The suitable protein elution solution is at 60% acetonitrile with an immersion time of 4 h. Our approach has resulted in the possibility of improving filter membranes for protein enrichment and storage in a variety of biological fluids.
Using surveillance data for early warning modelling of highly pathogenic avian influenza in Europe reveals a seasonal shift in transmission, 2016–2022
Authors: Jung Kjær Lene , Ward Michael P. , Boklund Anette Ella , Larsen Lars Erik , Hjulsager Charlotte Kristiane , Kirkeby Carsten Thure
Published: September 2023

Avian influenza in wild birds and poultry flocks constitutes a problem for animal welfare, food security and public health. In recent years there have been increasing numbers of outbreaks in Europe, with many poultry flocks culled after being infected with highly pathogenic avian influenza (HPAI). Continuous monitoring is crucial to enable timely implementation of control to prevent HPAI spread from wild birds to poultry and between poultry flocks within a country. We here utilize readily available public surveillance data and time-series models to predict HPAI detections within European countries and show a seasonal shift that happened during 2021–2022. The output is models capable of monitoring the weekly risk of HPAI outbreaks, to support decision making.
Amino-induced cadmium metal–organic framework based on thiazole ligand as a heterogeneous catalyst for the epoxidation of alkenes
Authors: Moghadaskhou Fatemeh , Hosseini Akram Karbalaee , Tadjarodi Azadeh , Abroudi Mehdi
Published: September 2023

Selective epoxidation of olefins is of high interest in the chemical industry due to the many applications of epoxides. This study reports on the synthesis of Cd-MOF, [Cd(DPTTZ)(5-AIP)] (IUST-1) (where DPTTZ = 2, 5-di (pyridine-4-yl) thiazolo [5, 4-d] thiazole, 5-AIP = 5-Aminoisophthalic acid), by a reflux method, which can be considered as a fast and simple process. The morphology and structure of the synthesized IUST-1 were determined by using FE-SEM (Field Emission Scanning Electron Microscopy), EDX (Energy Dispersive Analysis of X-ray), Mapping (Elemental Mapping), CHNS (Elemental analysis), XRD (X-Ray Diffraction), FT-IR (Fourier Transform Infrared), and TGA (Thermo Gravimetric Analysis). The epoxidation of cyclooctene was investigated using the activity of catalytic IUST-1. The results showed that in the presence of tert-butyl hydroperoxide and CCl4 in a 1:2 alkene/oxidant ratio, a high epoxide yield (99.8%) was obtained. In addition, IUST-1 can be easily separated by simple filtration and recycled five times successfully with a slight decrease in activity. This compound has some advantages such as high yield, short reaction time, and ease of reuse, which make it a suitable heterogeneous catalyst for the epoxidation of cyclooctene.
A comprehensive evaluation of regional carbon emission based on the composite model in China: a case study of Huaibei city (China)
Authors: Wen Zheng , Yang Ziwei , Xing Qinfeng
Published: September 2023

Formulating carbon emission reduction at the regional level is key to achieving the “dual carbon” strategy. A composite model is used to analyze the carbon emission reduction in Huaibei City based on the data from 2012 to 2021 and predict its change trend of carbon emission from 2022 to 2030. The study finds that: (1) the effects of observed factors on carbon emission in Huaibei City are complicated. Among them, the secondary industry has the greatest impact on carbon emission (weight is 0.32), and it is the key constraint factor of carbon emission. Population has the smallest impact on carbon emission (weight is 0.13), but its obstacle effect is significant. (2) The observed factors have a significant positive effect on the “dual carbon” strategy, but the improvement pressure is high. Among them, the conditions of all indicators have been improved except population, and it is found that each indicator can reach the level I before 2030, the “dual carbon” strategy can be achieved. This study deepens the understanding of regional carbon emission in China and the following conclusions are formed: (1) Grasping the carbon reduction effect of urbanization on the population to consolidate the new model of low-carbon development. (2) Identifying the key areas of carbon emission reduction to build a low-carbon emission oriented industrial system. (3) Strengthening the technological innovation of carbon emission reduction to achieve the strategic goal of “dual-carbon”.
Prediction of DDoS attacks in agriculture 4.0 with the help of prairie dog optimization algorithm with IDSNet
Authors: Vatambeti Ramesh , Venkatesh D. , Mamidisetti Gowtham , Damera Vijay Kumar , Manohar M. , Yadav N. Sudhakar
Published: September 2023

Integrating cutting-edge technology with conventional farming practices has been dubbed “smart agriculture” or “the agricultural internet of things.” Agriculture 4.0, made possible by the merging of Industry 4.0 and Intelligent Agriculture, is the next generation after industrial farming. Agriculture 4.0 introduces several additional risks, but thousands of IoT devices are left vulnerable after deployment. Security investigators are working in this area to ensure the safety of the agricultural apparatus, which may launch several DDoS attacks to render a service inaccessible and then insert bogus data to convince us that the agricultural apparatus is secure when, in fact, it has been stolen. In this paper, we provide an IDS for DDoS attacks that is built on one-dimensional convolutional neural networks (IDSNet). We employed prairie dog optimization (PDO) to fine-tune the IDSNet training settings. The proposed model's efficiency is compared to those already in use using two newly published real-world traffic datasets, CIC-DDoS attacks.
The ground state of the Kondo insulator
Authors: Karnaukhov Igor N.
Published: September 2023

The Kondo insulator (KI) is the state of an electron liquid in the Kondo lattice at half filling, studied within the mean field approach. We demonstrate, that the $${Z}_2$$

Z
2

-field, which is formed by interaction between electrons and local moments, leads to an insulator state in a lattice with a double cell lattice. In the ground state, electrons and local moments form singlets; in this case, no spin or charge density waves are realized in a lattice with a double cell. The Majorana-type gap spectrum of the quasi-particle excitations is realized in the $${ Z}_2$$

Z
2

-field. The gap in the spectrum decreases with increasing external magnetic field; it closes at a critical value at the insulator-metal phase transition point. In metal phase the lattice remains with a double cell. Thus, the introduction of the $${ Z}_2$$

Z
2

-field allows us to answer the key question what is the ground state of KI.
Splenic hilar lymph node dissection enhances survival in Bormann type 4 gastric cancer
Authors: Jeong Oh , Lee Han Hong , Hur Hoon , Kim Hyoung-Il
Published: September 2023

Splenic hilar (no.10) lymph node dissection during total gastrectomy is no longer recommended for advanced proximal gastric cancer. However, the treatment efficacy of no.10 lymph node dissection in Borrmann type 4 tumors remains unclear. We enrolled 539 patients who underwent total gastrectomy for Borrmann type 4 tumors between 2006 and 2016 in four major institutions in Korea. We compared the long-term survival of the no.10 lymph node dissection (n = 309) and no-dissection groups (n = 230) using the propensity score (inverse probability of treatment weighting). The treatment effects of no.10 lymph node dissection were estimated in the weighted sample using the Cox proportional hazards regression model with a robust sandwich-type variance estimator. After inverse probability of treatment weighting, there were 540.4 patients in the no.10 lymph node dissection group and 532.7 in the no-dissection group. The two groups showed well-balanced baseline characteristics, including tumor node metastasis stage. The 5-year survival rates in the no.10 lymph node dissection and no-dissection groups were 45.7% and 38.6%, respectively (log-rank p = 0.036, hazard ratio 0.786, 95% confidence interval 0.630–0.982). Multivariate analysis revealed that no.10 lymph node dissection was an independent favorable prognostic factor (adjusted hazard ratio 0.747, 95% confidence interval 0.593–0.940) after adjusting for other prognostic factors. Sensitivity analyses in other inverse probability of treatment weighting models and the propensity score matching model showed similar results. Patients undergoing no.10 lymph node dissection showed improved survival compared to those without. No.10 lymph node dissection is recommended during total gastrectomy for patients with Borrmann type 4 gastric cancer.
Confidence-aware self-supervised learning for dense monocular depth estimation in dynamic laparoscopic scene
Authors: Hirohata Yasuhide , Sogabe Maina , Miyazaki Tetsuro , Kawase Toshihiro , Kawashima Kenji
Published: September 2023

This paper tackles the challenge of accurate depth estimation from monocular laparoscopic images in dynamic surgical environments. The lack of reliable ground truth due to inconsistencies within these images makes this a complex task. Further complicating the learning process is the presence of noise elements like bleeding and smoke. We propose a model learning framework that uses a generic laparoscopic surgery video dataset for training, aimed at achieving precise monocular depth estimation in dynamic surgical settings. The architecture employs binocular disparity confidence information as a self-supervisory signal, along with the disparity information from a stereo laparoscope. Our method ensures robust learning amidst outliers, influenced by tissue deformation, smoke, and surgical instruments, by utilizing a unique loss function. This function adjusts the selection and weighting of depth data for learning based on their given confidence. We trained the model using the Hamlyn Dataset and verified it with Hamlyn Dataset test data and a static dataset. The results show exceptional generalization performance and efficacy for various scene dynamics, laparoscope types, and surgical sites.