bluuebunny/crossref_metadata_2025 huggingface dataset:
Desafios da Pandemia para o Futuro da Educação: O Caso Coppead
Authors: Campos Roberta Dias , Tavares Elaine , Chimenti Paula C. P. de Souza , Marques Leonardo
Published: May 2021

ABSTRACT This teaching case describes the process experienced by Coppead, one of the main graduate schools in business in Brazil, to adapt to e-learning. The change is driven by the social isolation adopted in the country due to the COVID-19 pandemic. The case reports on the decisions that the faculty collegiate, led by the director Elaine Tavares, has needed to take to circumvent the quarantine and ensure teaching continuity at Master, Doctoral, and Executive MBA levels. The case discusses the main challenges during the transition, but most importantly highlights the strategic opportunities that this shift has offered for innovation in the coming years.
A TECNOLOGIA SOCIAL NA PROGRAMAÇÃO DE UM CURRÍCULO CRÍTICO-TRANSFORMADOR NA EDUCAÇÃO EM CIÊNCIAS
Authors: Archanjo Junior Miguel Guilhermino de , Gehlen Simoni Tormohlen
Published: May 2021

RESUMO: O objetivo da presente pesquisa1 consiste em investigar o papel da Tecnologia Social (TS) na apreensão e superação de algumas contradições sociais que constituem um Tema Gerador. Para isso, foi elaborada e implementada uma atividade didático-pedagógica, baseada na TS, em uma comunidade escolar, localizada em Ilhéus-BA, durante um processo formativo de professores da Educação Infantil, com foco na Educação em Ciências. Metodologicamente, a pesquisa compreendeu duas etapas: i) seleção, planejamento e elaboração da atividade baseada na TS; ii) implementação da atividade com as crianças. Dentre os resultados, constatou-se que o processo de Investigação Temática, na obtenção de Temas Geradores, articulado aos fundamentos da TS, como a autonomia e tomada de decisões, potencializou as ações colaborativas durante o curso de formação de professores, na elaboração das atividades no âmbito da Educação em Ciências. Além disso, foi identificada a autonomia das crianças no enfrentamento das contradições sociais locais, mediante a efetivação das atividades relacionadas aos problemas concretos locais.
Anatomical study of Orchidaceae epiphytes species occurring in indigenous territory in the Parque Estadual da Serra do Tabuleiro (P.E.S.T.), Santa Catarina, Brazil
Authors: Blanco Graziela Dias , Hanazaki Natalia , Rodrigues Ana Claudia
Published: May 2021

Abstract Besides their ecological importance, epiphytic species of Orchidaceae play economic and social roles through their commercialization and some are at great risk of extinction. The objectives of this study were to characterize the leaf and root anatomy of fourteen epiphytic Orchidaceae species, which occur in indigenous territory in the Parque Estadual da Serra do Tabuleiro (P.E.S.T.), Santa Catarina, Brazil and to identify adaptive anatomical characteristics related to the epiphytic habit. The species are commercialized by the Guarani and were collected during interviews and guided tours with Guarani in the indigenous territory. The results reveal the species have many morphoanatomical structures that are useful during water shortages resulting from the epiphytic habit. Notable characteristics are related to reserving water (i.e., pseudobulbs and a hypodermis with water-storage cells) and resistance to desiccation in the leaf (i.e., conspicuous cuticle, suprastomatic chamber and extraxylary and pericyclic fibers) and root (i.e., tilosomes and/or exodermal thickening and cortex cells with phi thickenings or sclereids). Descriptions and the identification of adaptive characteristics of epiphytic plant species are useful for conservation and cultivation studies, especially for plants commercially used by the Guarani Indians.
Diversity of Bignoniaceae in coastal Piauí, Northeast Brazil
Authors: Santos Daniela Aguiar , Silva Maria Francilene Souza , Nascimento Maria Gracelia Paiva , Mayo Simon Joseph , Andrade Ivanilza Moreira de
Published: May 2021

Abstract The present study is a taxonomic treatment of Bignoniaceae from the four municipalities of the coastal region of Piauí state (Cajueiro da Praia, Ilha Grande, Luís Correia, Parnaíba) in Northeast Brazil, based on morphological study of newly collected and existing herbarium material. The study recorded 26 species in 12 genera: Adenocalymma, Anemopaegma, Bignonia, Cuspidaria, Dolichandra, Fridericia, Handroanthus, Lundia, Neojobertia, Pleonotoma, Stizophyllum and Tanaecium. Apart from Handroanthus impetiginosus, which belongs to tribe Tecomeae, all other species belong to tribe Bignonieae. Five species (Adenocalymma apparicianum, A. pedunculatum, Anemopaegma heringeri, A. prostratum, Dolichandra hispida) are new records for the state of Piauí, 15 species are endemic to Brazil, and one has “Vulnerable” conservation status. The results emphasize the importance of taxonomic studies for knowledge of biodiversity and threats to native species, and reinforce the importance of conserving the region’s flora. Species descriptions, illustrations, identification keys and information on geographic distribution and habitat are provided.
Flora of Ceará, Brazil: Onagraceae
Authors: Nascimento Hugo Pereira do , Matias Lígia Queiroz
Published: May 2021

Abstract This study aimed to provide the floristic survey of Onagraceae in Ceará state. The floristic study consisted of analyzing material deposited in the herbaria EAC, ESA, FUEL, HCDAL, HUEFS, HUVA, HVASF, INPA, K, MO, NY, P, RB, UFRN and US, as well as field work carried out between 2015 and 2017. In the study area, Onagraceae is represented by the genus Ludwigia, and seven species were recorded: L. erecta, L. helminthorrhiza, L. hyssopifolia, L. leptocarpa, L. nervosa, L. octovalvis and L. tomentosa. All seven species were also sampled in Conservation Units, with L. erecta recorded in six of them. L. erecta and L. helminthorrhiza have a broader distribution in the state. L. nervosa and L. tomentosa are indicated as new occurrences for Ceará, both with only one record in the south of the state, expanding their range in Northeastern Brazil. The information in this manuscript allows identification of Onagraceae representatives in Ceará state, through morphological descriptions, identification keys, taxonomic comments, illustrations, photographs and geographic distribution data.
Efeito de emissões âncoras de vozes sintetizadas na avaliação perceptivo-auditiva da voz
Authors: Santos Priscila Campos Martins dos , Vieira Maurílio Nunes , Sansão João Pedro Hallack , Gama Ana Cristina Côrtes
Published: May 2021

RESUMO Objetivo Analisar se a utilização de emissões âncoras de vozes sintetizadas na avaliação perceptivo-auditiva melhora a concordância intra e interavaliador. Método Trata-se de um estudo de natureza quantitativa. Foram selecionados 32 avaliadores inexperientes que realizaram, em um aplicativo criado pelos autores, duas atividades: Atividade Calibrador Ativo – avaliação perceptivo-auditiva dos parâmetros rugosidade e soprosidade como 0-ausência de desvio, 1-desvio leve, 2-desvio moderado ou 3-desvio intenso de 25 vozes com o apoio de emissões âncoras de vozes sintetizadas; e Atividade Calibrador Inativo – avaliação perceptivo-auditiva dessas mesmas vozes sem o apoio de emissões vocais âncoras. As vozes foram aleatorizadas em cada atividade, e a ordem de realização das atividades foi sorteada para cada avaliador, sendo que a segunda atividade foi realizada 15 dias após a primeira. Para análise da concordância intra e interavaliadores foi utilizado o coeficiente Kappa, e para comparação entre as concordâncias foi utilizado o intervalo de confiança (IC). Resultados A concordância interavaliadores foi maior para o grau intenso do parâmetro soprosidade na Atividade Calibrador Ativo quando comparada à Atividade Calibrador Inativo, assim como a concordância intra-avaliadores do parâmetro rugosidade. Conclusão O uso de emissões âncoras de vozes sintetizadas diretamente na avaliação melhora a concordância intra e interavaliadores na análise perceptivo-auditiva da voz.
Diagnóstico de anquiloglossia em recém-nascidos: existe diferença em função do instrumento de avaliação?
Authors: Fraga Mariana do Rêgo Barros de Andrade , Barreto Kamila Azoubel , Lira Thaís Christine Barbosa , Menezes Valdenice Aparecida de
Published: May 2021

RESUMO Objetivo Diagnosticar a anquiloglossia em recém-nascidos, comparando dois instrumentos de avaliação do frênulo lingual. Método Tratou-se de um estudo transversal, realizado em Recife, PE, Brasil no ano de 2018, com 147 mães/recém-nascidos com idade de até 30 dias de vida. Foram utilizados o Instrumento Bristol Tongue Assessment Tool (BTAT) e o Protocolo de Avaliação do Frênulo da Língua para Bebês (“Teste da Linguinha”). Dados sociodemográficos também foram anotados. Para a comparação entre os dois métodos de diagnóstico da anquiloglossia, foi utilizado o teste de McNemar e foram obtidos o valor da concordância de Kappa e o respectivo intervalo de confiança. Resultados A presença de anquiloglossia foi de 4,8%, quando diagnosticada por meio do BTAT, e de 17,0%, quando utilizado o “Teste da Linguinha”. Com relação ao sexo, 53,1% dos recém-nascidos eram do sexo masculino e 46,9% do sexo feminino; contudo, não houve associação entre a anquiloglossia e o sexo do recém-nascido nos dois métodos de avaliação. Conclusão O diagnóstico da anquiloglossia em recém-nascidos variou em função do instrumento de avaliação utilizado.
O trabalho mudou-se para casa: trabalho remoto no contexto da pandemia de COVID-19
Authors: Araújo Tânia Maria de , Lua Iracema
Published: May 2021

Resumo Objetivo: discutir os elementos vivenciados pelos(as) trabalhadores(as) com a ampla implementação de atividades laborais remotas, realizadas em casa, com auxílio das tecnologias de informação-comunicação, no contexto da pandemia de COVID-19. Métodos: com base em dados oficiais e revisão de literatura, discutem-se características do trabalho remoto (TR) e suas potenciais repercussões, enfatizando-se questões de gênero. Resultados: medidas de controle e prevenção contra a COVID-19, sobretudo o distanciamento social, mudaram o cotidiano social e familiar. Uma parcela de trabalhadores(as) manteve suas atividades laborais em casa. O TR foi imposto sem as condições estruturais e de treinamento necessárias e intensificou os efeitos do trabalho sem limites temporais definidos. Em casa, novas demandas surgiram (acompanhamento escolar e aumento de demandas por higienização e limpeza). Discussão: com a perda de fronteiras, o mundo privado torna-se público, a casa é incorporada ao mundo do trabalho. Novas questões emergem. Quais demandas surgem nesse novo arranjo produtivo-reprodutivo? Quais alterações se produzem nas atividades domésticas e de cuidados da família? Essas questões tendem a perdurar, mesmo passada a situação crítica da pandemia. Parte desse modo de operar os processos de trabalho permanecerá, e a vida em sociedade será modulada por essas transformações. Esses desafios deverão mobilizar atenção e intervenção.
PODE UMA LEI PROGRESSISTA ACELERAR UMA TRAJETORIA DE GRANDE LENTIDÃO? MULHERES NOS CONSELHOS DE ADMINISTRAÇÃO EM PORTUGAL
Authors: Casaca Sara Falcão , Guedes Maria João , Marques Susana Ramalho , Paço Nuno
Published: May 2021

Este artigo analisa o impacto do novo marco regulatório que entrou em vigor em Portugal em janeiro de 2018, a chamada lei das cotas de gênero, que determina uma composição mais equilibrada de mulheres e homens nos conselhos de administração das empresas cotadas na Bolsa de Valores Euronext Lisbon e das empresas do setor público. O artigo começa por contextualizar o debate sobre a sub-representação de mulheres nos conselhos de administração e sobre o novo marco de políticas com efeito vinculativo, introduzido em vários países da União Europeia (UE) e em Portugal. Examina, em seguida, os dados relativos à representação de homens e mulheres nos conselhos de administração das empresas cotadas em bolsa. Conclui-se que a introdução desta medida legislativa de natureza vinculativa em Portugal acelerou o movimento em direção a uma maior representação das mulheres nos conselhos de administração das empresas cotadas em bolsa, representando um novo impulso ao progresso neste domínio, porém lento, gerado pelos anteriores incentivos que visaram estimular a ação voluntária por parte das próprias empresas e promover medidas de autorregulação. Um dos principais desafios consiste, ainda, na passagem de um maior equilíbrio numérico de gênero para uma igualdade substantiva nos conselhos de administração, aumentando ao mesmo tempo a representação das mulheres em cargos de poder e influência efetiva nos processos decisórios.
Necropolítica e a corrida tecnológica: notas sobre ensaios clínicos com vacinas contra o coronavírus no Brasil
Authors: Castro Rosana
Published: May 2021

Resumo Com o avanço da pandemia de Covid-19, iniciou-se uma corrida tecnológica para o desenvolvimento de vacinas. Diversas pesquisas estão em curso no mundo e quatro candidatas a vacina estão em teste no Brasil. Neste artigo, problematizo como dispositivos necropolíticos sanitários, econômicos e políticos, racial e socialmente articulados, configuraram o Brasil como um epicentro da pandemia e um “laboratório” de vacinas no ano de 2020, e analiso como essa situação foi localmente positivada como um reconhecimento internacional das competências do país em participar do mercado global de pesquisas farmacêuticas. Reflito, ainda, sobre como o envolvimento nos estudos não necessariamente garante o acesso futuro da população brasileira às vacinas aqui testadas, pois tais tecnologias são objeto de correntes disputas comerciais desiguais, que tendem a reforçar as condições que contribuíram para conduzir o país à tragédia sanitária da qual se espera surgir a solução para a pandemia.
La sociedad del espanto. Mallas de vidas en cuarentena
Authors: Bonet Octavio
Published: May 2021

Resumen La pandemia del virus Covid-19 tiene el efecto paradójico de ponernos en una situación completamente nueva para el mundo moderno y, al mismo tiempo, movilizar conceptos que conocemos desde hace mucho tiempo. El objetivo de este artículo es proponer que la pandemia del coronavirus explicitó el entramado del mundo y al hacerlo nos transformó en lo que llamo la “sociedad del espanto” habitada por una nueva subjetividad que se caracteriza por la figura de los “nuevos heridos”, desarrollada por Catherine Malabou. A través de establecer asociaciones entre Mauss, Bateson e Ingold se intenta entender las relaciones entre el hombre y el mundo como un conjunto entrelazado de líneas de vida, crecimiento y movimiento, que permite comprender las relaciones entre las dimensiones biológica, psicológica y social. Se propone pensar la pandemia y la cuarentena como un evento traumático a través de la cual se podría construir una nueva identidad colectiva e individual.
Descolonizando a saúde planetária
Authors: Biehl João
Published: May 2021

Resumo Intimamente conectada com decisões políticas e interesses de mercado, a pandemia de Covid-19 é uma calamidade crônica agudizada que assola o mundo inteiro, desestabilizando conhecimentos e práticas biomédicas hegemônicas e revelando a precariedade dos sistemas de saúde pública, assim como a impotência profunda das redes de seguridade social e a fragilidade dos laços de solidariedade que imaginávamos estáveis. O artigo reflete sobre os desafios impostos aos cientistas sociais e profissionais da saúde em contextos neoliberais e à beira da autocracia num momento em que seus métodos e conceitos-chave são chamados a dar conta de forma mais adequada aos complexos enredos territorializados pela emergência generalizada e a cultivar micro, meso e macromodos de resistência. Assim, instrumentos analíticos da antropologia médica e da saúde global crítica, como vulnerabilidade estrutural, determinantes políticos, racialização, farmaceuticalização e descolonização do saber, podem ser valiosos recursos para leitura do presente e de intervenção nele, mas são também desafiados pela dinâmica realidade que se desdobra. Contra o pano de fundo de uma crescente tensão entre a tecnocrática produção de microdispositivos humanitários e o desenvolvimento de uma ciência integrada de saúde planetária, o artigo ilumina a urgência da articulação de uma ética amazônica de cuidado.
Psychometric properties of the Jefferson Empathy Scale in four nursing student faculties
Authors: Castillo Víctor Pedrero , Calzadilla-Núñez Aracelis , Moya-Ahumada Claudia , Torres-Martínez Pilar , Pastén Pablo Castro , Díaz-Narváez Víctor Patricio
Published: May 2021

ABSTRACT Objective To evaluate the psychometric properties of the Jefferson Medical Empathy Scale, Spanish version (JSE-S), its factorial structure, reliability, and the presence of invariance between genders in the behavior of empathy levels among Chilean nursing students. Method Instrumental research design. The JSE-S was applied to 1,320 nursing students. A confirmatory factor analysis was used. An invariance study between genders was carried out. Descriptive statistics were estimated. Between genders, Student’s T distribution was applied alongside a homoscedasticity analysis. The level of significance was α ≤ 0.05. Results The confirmatory factor analysis determined the existence of three dimensions in the matrix. The statistical results of the invariance tests were significant, and allowed comparison between genders. Differences were found between mean empathy values, as well as in some of its dimensions between genders. Conclusion The factor structure of empathy data and its dimensions is in correspondence with the underlying three-dimensional model. There are differences in empathy levels and their dimensions between genders, with the exception of the compassionate care dimension, which was distributed similarly. Women were more empathetic than men.
Um planejamento ortogonal guliveriano: uma leitura modular da Túrio do período clássico
Authors: Peixoto Renan Falcheti , Florenzano Maria Beatriz Borba
Published: May 2021

Abstract: This paper uses the Gulliverian metaphor to examine the organization of a well-known Classical orthogonal planning in Magna Graecia, south Italy. After observing the relationship between the elements of the urban grid of Thourioi, we will propose the application of a modular unit formed by the sum of ten Attic feet by the geometer of its urban plan. According to our main argument here, this module orientated the land-measurement of Thourioi by co-measuring the width of ithe roadway network and width/length of blocks, lots, and “major rectangles”. Furthermore, certain alignments in its planning are physically established, as it will be demonstrated in the case of its major roads. Thourioi calls forth through its compositional structure of older formulas a wider horizon of orthogonal planning tradition, an ancient scansion rhythm reified in archaeological patterns of many Greek Western foundations since the VIII century BC.
Visão sobre a escravidão nos tratados médicos dedicados às doenças dos escravos no império colonial português: o caso do Brasil entre 1735 e 1801
Authors: Eugenio Alisson
Published: May 2021

Resumo: Este artigo tem por objetivo comparar a visão sobre a escravidão em dois livros médicos, que circularam no Brasil colonial, sobre doenças de escravos (um escrito e o outro traduzido por cirurgiões que atuaram em Minas Gerais). O primeiro deles é o tratado médico de Luís Gomes Ferreira, Erário mineral, publicado em Lisboa no ano de 1735. O segundo é a tradução feita em 1801 por Antônio Vieira de Carvalho do manual médico Observações sobre enfermidades dos negros, publicado em Paris em 1776. Ao compará-los será mostrado: 1) que eles são indicadores das maneiras como as relações de produção escravistas foram percebidas na capitania mais rica e urbanizada da América portuguesa em épocas distintas de sua experiência histórica; 2) que houve mudanças significativas entre eles em relação à forma, ao suporte ideológico e ao conteúdo do modo de ver o mundo do cativeiro.
Desembarque da segunda escravidão na historiografia brasileira
Authors: Cravo Télio
Published: May 2021

Resumo: O livro coletivo tem por objetivo analisar o papel da escravidão na configuração do capitalismo no Brasil no século XIX. Para tanto, os autores utilizam o aparato fornecido pelo conceito de segunda escravidão. A resenha aponta que essa incorporação conceitual retoma tensões entre a história e as interpretações econômicas.
Renal Expression of Fibrotic Matrix Proteins and of Transforming Growth Factor-β (TGF-β) Isoforms in TGF-β Transgenic Mice
Authors: MOZES MIKLOS M. , BÖTTINGER ERWIN P. , JACOT TERRY A. , KOPP JEFFREY B.
Published: May 2021

Renal pathology in mice that are transgenic for the murine albumin enhancer/promoter linked to a full-length porcine transforming growth factor-β1 (TGF-β1) gene has been described previously. In these mice, transgene expression is limited to the liver and the plasma level of TGF-β is increased. The earliest renal pathologic change is glomerulosclerosis, at 3 wk of age, and this is followed by tubulointerstitial fibrosis. In this study, it was hypothesized that circulating TGF-β1 increases renal extracellular matrix accumulation and activates local TGF-β gene expression. Immunostaining at 5 wk revealed increased amounts of collagen I and III within the mesangium, glomerular capillary loops, and interstitium, while the amount of collagen IV was normal. Similarly, Northern analysis showed increased expression of mRNA encoding collagen I and III, as well as biglycan and decorin, while the expression of collagen IV was unchanged. These changes began as early as 1 wk of age, a time before the appearance of glomerulosclerosis. To evaluate matrix degradation, collagenase IV activity was evaluated by gelatin zymography and an increase in matrix metalloproteinase-2 was found. Finally, the production of tissue inhibitors of metalloproteinase was evaluated. Tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA was increased 18-fold, while TIMP-2 and TIMP-3 were unchanged. In 2-wk-old transgenic kidney, local expression of TGF-β1, β2, and β3 protein was similar to wild-type mice. In 5-wk-old transgenic mice, TGF-β1 and β2 protein was present in increased amounts within glomeruli, and renal TGF-β1 mRNA was increased threefold. It is concluded that elevated levels of circulating TGF-β1 may act on the kidney to increase matrix protein production and decrease matrix remodeling. Only after glomerulosclerosis is established does local glomerular overproduction of TGF-β become manifest.
Expression of the MRP2 Gene-Encoded Conjugate Export Pump in Human Kidney Proximal Tubules and in Renal Cell Carcinoma
Authors: SCHAUB THOMAS P. , KARTENBECK JÜRGEN , KÖNIG JÖRG , SPRING HERBERT , DÖRSAM JOACHIM , STAEHLER GERD , STÖRKEL STEPHAN , THON WALTER F. , KEPPLER DIETRICH
Published: May 2021

Human kidney proximal tubule epithelia express the ATP-dependent export pump for anionic conjugates encoded by the MRP2 (cMRP/cMOAT) gene (symbol ABCC2). MRP2, the apical isoform of the multidrug resistance protein, is an integral membrane glycoprotein with a molecular mass of approximately 190 kD that was originally cloned from liver and localized to the canalicular (apical) membrane domain of hepatocytes. In this study, MRP2 was detected in human kidney cortex by reverse transcription-PCR followed by sequencing of a 826-bp cDNA fragment and by immunoblotting using two different antibodies. Human MRP2 was localized to the apical brush-border membrane domain of proximal tubules by double and triple immunofluorescence microscopy including laser scanning microscopy.

The expression of MRP2 in renal cell carcinoma was studied by reverse transcription-PCR and immunoblotting in samples from patients undergoing tumor-nephrectomy without prior chemotherapy. Clear-cell carcinomas, originating from the proximal tubule epithelium, expressed MRP2 in 95% (18 of 19) of cases. Immunofluorescence microscopy of MRP2 in clear-cell carcinoma showed a lack of a distinct apical-to-basolateral tumor cell polarity and an additional localization of MRP2 on intracellular membranes. MRP2, the first cloned ATP-dependent export pump for anionic conjugates detected in human kidney, may be involved in renal excretion of various anionic endogenous substances, xenobiotics, and cytotoxic drugs. This conjugate-transporting ATPase encoded by the MRP2 gene has a similar substrate specificity as the multidrug resistance protein MRP1, and may contribute to the multidrug resistance of renal clear-cell carcinomas.
Effects of High-Dose Folic Acid and Pyridoxine on Plasma and Erythrocyte Sulfur Amino Acids in Hemodialysis Patients
Authors: SULIMAN MOHAMED E. , FILHO JOSÉ C. DIVINO , BÀRÀNY PETER , ANDERSTAM BJÖRN , LINDHOLM BENGT , BERGSTROM JONAS
Published: May 2021

In this investigation, sulfur amino acids (sAA) and sulfhydryls were determined in the plasma and erythrocytes (RBC) of 10 uremic patients on regular hemodialysis (HD) treatment and 10 healthy subjects, before and after supplementation with 15 mg/d of folic acid and 200 mg/d of pyridoxine for 4 wk. The basal total plasma concentrations of homocysteine (Hcy), cysteine (Cys), cysteinylglycine (Cys-Gly), γ-glutamylcysteine (γ-Glu-Cys), glutathione (GSH), and free cysteinesulfinic acid (CSA) were significantly higher in HD patients when compared to healthy subjects, whereas methionine (Met) and taurine (Tau) concentrations were the same in the two groups. HD patients showed significantly higher RBC levels of Hcy and Cys-Gly, whereas the RBC concentrations of Met, Cys, Tau, and GSH were not different from those in the healthy subjects. The plasma concentrations of sAA and sulfhydryls differed compared with RBC levels in the healthy subjects and HD patients. In both groups, supplementation with high doses of folic acid and pyridoxine reduced the plasma Hcy concentration. In addition, increased plasma concentrations of Cys-Gly and GSH were found in the HD patients and of CSA in the healthy subjects. After vitamin supplementation, the RBC concentrations of Hcy, Cys, and GSH increased and that of Tau decreased in healthy subjects. The only significant finding in RBC of HD patients was an increase in GSH levels after supplementation. This study shows several RBC and plasma sAA and sulfhydryl abnormalities in HD patients, which confirms earlier findings that RBC and plasma pools play independent roles in interorgan amino acid transport and metabolism. Moreover, high-dose supplementation with folic acid and pyridoxine significantly reduced Hcy levels, but did not restore the sAA and sulfhydryl abnormalities to normal levels. The increase that was observed in GSH after vitamin supplementation may have a beneficial effect in improving blood antioxidant status in uremic patients. Finally, the findings of elevated plasma Cys levels correlating to the elevated plasma Hcy levels in the presence of elevated plasma CSA levels, both before and after vitamin supplementation, led to the hypothesis that a block in decarboxylation of CSA is linked to hyperhomocysteinemia in end-stage renal failure.
QT Dispersion in Patients with End-Stage Renal Failure and during Hemodialysis
Authors: LŐORINCZ ISTVÁN , MÁTYUS JÁNOS , ZILAHI ZSOLT , KUN CSABA , KARÁNYI ZSOLT , KAKUK GYÖRGY
Published: May 2021

Interlead variability of the QT interval in surface electrocardiogram (ECG), i.e., QT dispersion, reflects regional differences in ventricular recovery time, and it has been linked to the occurrence of malignant arrhythmias in different cardiac diseases. The purpose of the study was to assess the effect of hemodialysis on QT and corrected QT (QTc) interval and dispersion in chronic hemodialyzed patients. Data of 34 nondiabetic patients (male/female = 21/13; mean age, 54 ± 15 yr) on chronic hemodialysis were studied. Polysulfone capillaries and bicarbonate dialysate containing (in mEq/L) 135 Na+, 2.0 K+, 1.5 Ca2+, and 1.0 Mg2+ were used. Simultaneous 12-lead ECG were recorded before and after hemodialysis in a standard setting. The QT intervals for each lead were measured manually on enlarged (×3) ECG by one observer using calipers. Each QT interval was corrected for patient heart rate:

JOURNAL/jasn/04.03/00001751-199906000-00016/math_16MM1/v/2023-03-15T155848Z/r/image-jpeg

(in milliseconds [ms]). The average cycle intervals were 853 ± 152 ms predialysis and 830 ± 173 ms postdialysis; the difference was not significant. The maximal QT interval changed significantly from 449 ± 43 to 469 ± 41 ms (P < 0.01). The corrected maximal QT interval increased significantly from 482 ± 42 to 519 ± 33 ms (P < 0.01). The QT dispersion changed from 56 ± 15 to 85 ± 12 ms (P < 0.001) and the corrected QT interval dispersion from 62 ± 18 to 95 ± 17 ms (P < 0.001). During hemodialysis, the serum potassium and phosphate levels decreased from 5.5 ± 0.8 to 3.9 ± 0.5 (mM) and from 2.3 ± 0.5 to 1.6 ± 0.4 (mM), respectively, whereas calcium increased from 2.2 ± 0.23 to 2.5 ± 0.22 (mM). It is concluded that hemodialysis increases the QT and QTc interval and QT and QTc dispersion in patients with end-stage renal failure. Thus, it may be stated that the nonhomogeneity of regional ventricular repolarization increases during hemodialysis. Measurement of QT and QTc dispersion is a simple bedside method that can be used for analyzing ventricular repolarization during hemodialysis.
HLA-Derived Peptides as Novel Immunomodulatory Therapeutics
Authors: MURPHY BARBARA , KRENSKY ALAN M.
Published: May 2021

A growing body of experimental evidence demonstrates that synthetic peptides corresponding to linear sequences of MHC (HLA in humans) proteins have immunomodulatory effects in vitro and in vivo in animal models and in humans. Although the original concept was that these peptides inhibited antigen recognition at the MHC-T cell receptor interface via physical blockade, it is now clear that the mechanisms responsible for the myriad of functional effects are more complex. Recent findings show that some peptides affect signal transduction and cell cycle progression. Fragments of MHC molecules can dampen or downregulate immune responses via a variety of mechanisms. Some soluble MHC molecules or synthetic peptides are capable of inducing and maintaining immunologic tolerance in animals. This information suggests that synthetic peptides themselves or drugs mimicking their effects may represent a new class of immunotherapeutics.
Adenosine Activates Aromatic L-Amino Acid Decarboxylase Activity in the Kidney and Increases Dopamine
Authors: TAKEZAKO TAKANOBU , NODA KEITA , TSUJI EMIKO , KOGA MANABU , SASAGURI MANABU , ARAKAWA KIKUO
Published: May 2021

Renal sodium handling is important for regulating BP, and renal dopamine and adenosine play an important role in renal sodium handling, however the interaction of these hormones in the kidney was not clarified. In in vivo experiments, adenosine significantly increased water and sodium excretion by 50% compared with vehicle when infused into the left renal artery, accompanied by an increase in urinary dopamine excretion in the left kidney. Neither water-sodium excretion nor dopamine excretion changed in the vehicle-infused kidney. Aromatic L-amino acid decarboxylase activity in the left kidney was significantly higher than that in the noninfused right kidney. The increase in water-sodium excretion induced by adenosine was significantly inhibited by SCH23390, a selective D1 receptor antagonist. In in vitro experiments, porcine renal proximal tubular cells were incubated with 250 μM L-dopa and N6-cyclohexyladenosine, an adenosine type 1 receptor agonist, after treatment with adenosine deaminase. N6-cyclohexyladenosine significantly increased dopamine formation at a concentration of 10-9 to 10-7 M, and this was completely inhibited by 1,3-dipropyl-8-cyclopentylxanthin, an adenosine A1 antagonist. These results show that renal dopamine synthesis is stimulated by adenosine through the activation of aromatic L-amino acid decarboxylase and suggest that adenosine leads to an increase in renal dopamine and natriuresis.
Implementation and Technical Testing of a Robot for Future Use Inpatient Care (Covid-19)Implementation and Technical Testing of a Robot for Future Use In Patients Care (Covid-19)
Authors:   , Rico-Mesa E. M.
Published: May 2021

The present paper describes the process of conformation in a record time of a mobile robot that has the functions of telemedicine. The robot is designed for a health institution in the city of Medellín Colombia to accompany patients and professionals in the care of the crisis caused by infection with the SARS-COV-2 virus (COVID-19). During this process, a technical test was applied to the Robot, employing medical care drills. Also, the viability of the robot in the clinic environment has been studied, presenting the positive and negative aspects through a SWOT analysis matrix and its targeting through action strategies.
Parallel Selection Protocol for the Maize ATLAS Project v1
Authors: Maize ATLAS Project The
Published: May 2021

As part of the Maize ATLAS project on adaptation and diversification along a latitudinal axis of the USA, this protocol describes procedures used for a parallel selection experiment. A tropical synthetic (TropicS) population was systematically selected for early flowering time at multiple locations managed by a team of research groups (project PIs: N. de Leon; S. Flint-Garcia; J. B. Holland; N. Lauter; S. Murray; W. Xu; R. J. Wisser). The protocol outlines experimental techniques and guidance for planting, sample tracking, tissue sampling, pollination, harvesting and record keeping. The protocol has been used to generate over 20 new populations of maize to investigate the phenotypic and genomic basis of response to selection. This work supported by the Agriculture and Food Research Initiative Grant No. 2011-67003-30342 from the USDA-NIFA (Agriculture and Natural Resources Science for Climate Variability and Change Program).
Analysis of D-Dimer Levels among Covid -19 Positive Patients in a Tertiary Care Hospital in Bangalore
Authors:   Microbiologist, Sagar hospital, Bangalore, Karnataka, India, S Dr. Manasa. , H. C Dr. Venkatesh Vikram ,   Medical Director, Sagar hospital DSI, Bangalore, Karnataka, India
Published: May 2021

Introduction: Pro-thrombotic changes are stimulated by Corona Virus as it has an affinity forendothelium and lung structures and this may explain its association with thrombotic events,reduction of pulmonary gas exchange, respiratory distress, and death. D-dimer is a specific markerof the breakdown of a fibrin clot and has been used as a diagnostic and prognostic marker in VTEand other coagulation disorders. Objectives: The objective of this study was to assess thecorrelation of the D-Dimer levels and disease severity among COVID-19 patients. Materials andmethods: This is a retrospective study done over 6 months from July 2020 to December 2020 in atertiary care hospital in Bangalore. All the COVID- 19 positive cases who were admitted to ourhospital were audited regarding the D-dimer levels during admission and the course of thetreatment. Results: Coagulation disorder occurred at the early stage of COVID-19 infection, with1066 (57.7%) patients having increased D-dimer levels. Out of 1846 COVID 19 patients 106(5.7%)patients died due to complications. 106 patients who deceased, all the patients had anincreased D dimer value either in the first lab test or in the consecutive tests. Among 106 patients56(52.8%) patients had increased D-dimer at the first lab test, 32 (30.1%) had D-dimer increasedat the second and 18(16.98%) in third lab tests. The increased D-dimer levels were closelyassociated with the progression of the disease and also the changes in the CT imaging. Conclusion:The increase in D-Dimer levels also increased the complications in the COVID-19 patient. So it isnecessary to continuously monitor D-dimer levels and labelled anticoagulation as management toolsfor COVID-19 disease to prevent complications and reduce interventions.
Analysis of ease of insertions, its attempts and time taken to insert for i-gel and cLMA in paediatric cases.
Authors:   Assistant professor, Department of Anaesthesia, D.K.S.P.G.I and research centre, Raipur, C.G, India, Jain Dr. Nimish , Taxak Dr. Susheela ,   Professor, Department of Anaesthesia, PGIMS, Rohtak, Haryana, India, Singh Dr. Karampal ,   Assistant Professor, Department of Anaesthesia, PGIMS, Rohtak, Haryana, India
Published: May 2021

Aim: Analysis of ease of insertions, its attempts and time taken to insert for i-gel and cLMA inpaediatric cases. Methods: We did a prospective, randomised single-blind study on Eighty patientsof either sex belonging to American Society of Anaesthesiologists (ASA) physical status class I or II,between 6 months to 8 years of age, scheduled to undergo elective surgery for less than one andhalf hour duration under general anaesthesia. In this study we analysed the ease of insertion,attempts and time were taken to insert the supraglottic airway device. Results: The ease ofinsertion observed was easy in 39(97.5%) in the i-gel group and 35(87.5%) in cLMA group in ourstudy. The i-gel was placed successfully in 39 out of 40 (97.5%) patients in the first attempt, andachieved 100% insertion on the second attempt. Correct positioning of cLMA in the first attempt wasseen in 35 out of 40 (87.5%) patients. The remaining 5 patients (12.5%) required a secondattempt. The average insertion time of cLMA (12.88 ± 1.771 seconds) was longer than the averagetime of insertion of i-gel (9.48 ± 1.037 seconds), and these differences were highly significantstatistically (p= 0.000). Conclusion: To conclude, i-gel and cLMA is effective and safe devices foruse in children. Both are easy to insert and have insignificant morbidity, however, time taken andattempts of insertions for i-gel was lesser than cLMA. Also, the ease of insertion was relatively easyfor i-gel than cLMA in pediatric cases.
A Proposed Ensemble Model for The Prediction of Coronavirus Anxiety Scale of Migrant Workers
Authors: GÜLDOĞAN Emek
Published: May 2021

Objective: This study aimed to evaluate the potential negative effects of the scattered migrant worker population on the anxiety level by estimating the coronavirus anxiety scale (CAS) of the COVID-19 anxiety scale with Gradient Boosting Tree (GBT).
Material and Methods: In this study, a public data set achieved from a questionnaire [developed using the Coronavirus Anxiety Scale (CAS)] was used to conduct on 1350 people over phone calls. GBT model was constructed for predicting the CAS score of migrant workers based on input variables including demographical data. Hyperparameters of the GBT model were tuned using Optimize Parameters (Evolutionary) operator, which seeks the optimum values of the selected parameters by an evolutionary computation approach. Hyperparameters of the GBT model were 50 for the number of trees, 5 for minimal depth, 0.044 for learning rate, and 1.0E-5 for minimum split improvement.
Results: A total of 1500 people, 758 (56.1%) male, and 592 (43.9%) female, participated in this study. The experimental findings demonstrated that the GBT yielded a root mean square error of 3.547±0.235, the absolute error of 2.943±0.154, relative error lenient of 31.54%±0.82%, squared error of 12.623±1.691 and correlation of 0.577±0.130.
Conclusions: Variable importance values for each input were calculated from the model-based results of the GBT model. The largest importance was achieved for income and the lowest was estimated for Covid-19 Infection. The calculated importances can be evaluated the potential impacts on the CAS score. In future works, different algorithms can be built for detailed predictions about COVID-19-related anxiety levels.
Dr. Parhon et Uréchie. Influence of the period of menstruation on the frequency of epilepsy. Revista Stüntelor medicale, 1908
Authors: Kovalevsky P. I.
Published: May 2021

In most cases, during the period of menstruation, epilepsy attacks intensify and become more frequent, but in a minority the situation is the opposite.
Dr. Baugl. Observation of mentally ill epileptics treated with hospital problems. Observations on insane Epeleptics treated imber Hospital principles. — The Journal of mental science, 1908
Authors: Kovalevsky P. I.
Published: May 2021

The author asks the questions: how to treat epileptics with mentally abnormal manifestations in hospitals, and answers the same way as all mentally ill patients. In this relationship are especially important: peace, bed keeping and careful observation.
Protocol of the next meeting of the Society of Neuropathologists and Psychiatrists at the Imperial Kazan University on March 18, 1909
Authors: Darshkevich L. О.
Published: May 2021

Chaired by prof. L.O.Darkshevich under the secretary of Dr. V.P. Pervushin. Attended by dd. member prof. V.P. Osipov, Dr. A. Sholomovich, I. A. Veselitsky, V. N. Osipova, N. A. Donskov, S. A. Bolberg, M. A. Chalusov, V. S. Boldyrev, guests Dr. VA Perimov, VI Kotelov, II Tsypkin, Kozlov, Persons and up to 30 people Ch. arr. senior medical students.
Rapid Postearthquake Field Reconnaissance, Paleoseismic Trenching, and GIS-Based Fault Slip Variability Measurements along the Mw 6.4 and Mw 7.1 Ridgecrest Earthquake Sequence, Southern California
Authors: Kozacı Özgür , Madugo Christopher M. , Bachhuber Jeffrey L. , Hitchcock Christopher S. , Kottke Albert R. , Higgins Katherine , Wade Adam , Rittenour Tammy
Published: May 2021

Understanding fault rupture deformation patterns, especially in complex fault zones, has fundamental implications on seismotectonic studies and hazard mitigation for the built environment. The 2019 Mw 6.4 and Mw 7.1 Ridgecrest earthquake ruptures offer an opportunity to quantify deformation patterns and surface displacements from a complex fault rupture. Our field reconnaissance, within 18 hr of the Mw 6.4 event, documented a complex and relatively broad fault deformation zone up to a few kilometers wide in the vicinity of a gas transmission pipeline intersected by the surface rupture south of Highway 178. The subsequent Mw 7.1 event resulted in similarly distributed surface fault deformation within a broad zone that crossed a second gas transmission pipeline located south of Highway 178. On 10 July, fault-normal pipeline assessment trenches were excavated at both locations and provided evidence for late Pleistocene fault rupture on both faults expressed as upward fault truncations and paleoliquefaction features. Subsequent imagery-based rupture-mapping facilitated identification and measurement of offset features that were not identified during field mapping. Fault displacement measurements document a gradual decrease in fault slip on rupture southwestward from the Mw 6.4 epicenter within the study area. However, displacement along the primary Mw 7.1 rupture decreased more drastically southeastward toward a structural complexity at a fault stepover expressed as a horsetail splay. Fault-normal slip distributions showed that majority of the surface deformation was accommodated along discrete fault strands within the primary fault zone across both ruptures. This work expands the catalog of high-fidelity coseismic rupture information used to better understand seismotectonic processes, while contributing to refinement of fault displacement models used in support of critical infrastructure design.
Machine-Learning-Based High-Resolution Earthquake Catalog Reveals How Complex Fault Structures Were Activated during the 2016–2017 Central Italy Sequence
Authors: Tan Yen Joe , Waldhauser Felix , Ellsworth William L. , Zhang Miao , Zhu Weiqiang , Michele Maddalena , Chiaraluce Lauro , Beroza Gregory C. , Segou Margarita
Published: May 2021

The 2016–2017 central Italy seismic sequence occurred on an 80 km long normal-fault system. The sequence initiated with the Mw 6.0 Amatrice event on 24 August 2016, followed by the Mw 5.9 Visso event on 26 October and the Mw 6.5 Norcia event on 30 October. We analyze continuous data from a dense network of 139 seismic stations to build a high-precision catalog of ∼900,000 earthquakes spanning a 1 yr period, based on arrival times derived using a deep-neural-network-based picker. Our catalog contains an order of magnitude more events than the catalog routinely produced by the local earthquake monitoring agency. Aftershock activity reveals the geometry of complex fault structures activated during the earthquake sequence and provides additional insights into the potential factors controlling the development of the largest events. Activated fault structures in the northern and southern regions appear complementary to faults activated during the 1997 Colfiorito and 2009 L’Aquila sequences, suggesting that earthquake triggering primarily occurs on critically stressed faults. Delineated major fault zones are relatively thick compared to estimated earthquake location uncertainties, and a large number of kilometer-long faults and diffuse seismicity were activated during the sequence. These properties might be related to fault age, roughness, and the complexity of inherited structures. The rich details resolvable in this catalog will facilitate continued investigation of this energetic and well-recorded earthquake sequence.
Engenharia Didática: análises preliminares e a priori para a noção dos Quaternions de Fibonacci.
Authors: Vieira Alves Francisco Regis , Vieira Renata Passos Machado , Machado Cruz Catarino Paula Maria
Published: May 2021

ResumoO modelo matemático que, segundo os livros de História da Matemática, é atribuído, equivocadamente ao matemático Leonardo Pisano, preserva hodiernamente um vigor irrefreável de um progresso maior de evolução e de generalidade. Não obstante, um caráter de oblívio total pode ser observado no que concerne a uma maior divulgação e, também, melhor formação do professor de Matemática, concernentemente a determinados assuntos matemáticos específicos. Diante de tal entrave, o artigo atual apresenta a descrição das análises preliminares e análise a priori de uma Engenharia Didática, com o tema quaternions (generalizados) de Fibonacci. A relevância deste assunto se evidencia, na medida em que, o mesmo pode ser encontrado apenas em artigos científicos de Matemática que reproduzem propriedades formais cifradas. Assim, com arrimo da Teoria das Situações Didáticas – TSD, o trabalho apresenta, de modo pormenorizado, um planejamento para as fases dialéticas de ação, formulação, validação e institucionalização. Por fim, a atual proposta explora elementos que balizam sua eventual aplicação e experimentação em sala de aula, tendo como público alvo, professores de Matemática em formação inicial.
Palavras-Chave: História da Matemática; Sequência de Fibonacci; Investigação histórica.
AbstractThe mathematical model, according to the History of Mathematics books, is attributed wrongly to the mathematician Leonardo Pisano, in our times preserves an unstoppable force for further progress of evolution and generality. Nonetheless, a complete forgetfulness character can be seen in relation to greater disclosure and also improved training of the mathematics teacher, concernentemente to specific mathematical topics. Faced with this obstacle, the current article presents a description of the preliminary analysis and a priori analysis of a Didactic Engineering, with the theme quaternions (generalized) Fibonacci. The importance of this matter is evidenced, in so far as the same can be found only in scientific articles Mathematics reproducing encrypted formal properties. So with retaining the Theory of Didactic Situations - TSD, the work presents, in detail, a plan for the dialectics stages of action, formulation, validation and institutionalization. Finally, the current proposal explores elements that guide its possible application and experimentation in the classroom, with the target audience, mathematics teachers in initial training.
Keywords: Didactical Engineering; Fibonacci´s sequence; Quaternion of Fibonacci; Historical investigation.