bluuebunny/crossref_metadata_2025 huggingface dataset:
The Implementatio of the Blended Learning Technologies at the Higher Military Educational Institution: Features of the Readiness Formation of the Future Special Purpose Specialists for Professional Activity
Authors: Rudynskyi Vitaly
Published: April 2024

The technology of blended learning, which combines the advantages of traditional classroom and electronic learning, is considered. It is noted that blended learning is characterized by a double significance (personally significant educational activity and proper organization of educational activity in electronic and traditional format), which contributes to the development of a cadet of a military educational institution as a subject of self-education, and forms his readiness for self-development in the future professional activity. An analysis of the features and essential characteristics of blended learning technology was carried out, its models were investigated, and approaches to introducing blended learning into the educational process of cadets of higher military educational institutions were described. The critical characteristics of blended learning, such as individualization of learning, productive, independent work, appropriate use of classroom time, active implementation of modern information and communication technologies, etc., are highlighted. The interaction of subjects: the teacher, students, electronic educational resources, and the roles assigned to them in the blended learning model are characterized. Electronic resources for implementing blended learning into practice (Google for Education cloud services with basic applications) are considered. The experience of using blended learning technology in the teaching process is described, which is implemented in the form of a three-stage educational model - independent work of cadets (viewing video materials to familiarize themselves with the theoretical material for this lesson, independent performance of tasks to check understanding of the reviewed material), classroom work (active types of educational activity) and post-audit work (independent generalization of the studied educational material). It was concluded that the introduction of blended training into the educational process of future particular purpose specialists, as well as its practical use at higher military educational institutions, contributes to the formation of cadets’ readiness for the activities of future military officers.
Design Procedure of the Digital Educational Resources for Economic and Managerial Education of the Master’s in IT Students
Authors: Antoniuk Dmytro , Vakaliuk Tetiana
Published: April 2024

Design and implementation of the digital educational resources into educational process enables acquiring of the practical experience by the students, that is crucial to their career in IT. It also brings modern technologies and innovative approaches to education. As a result, it improves involvement of the students and helps drive their academic results up. It is important to consider the fact that a master’s in IT may often occupy managerial roles in their future career. Understanding of the economic and managerial principles is crucial for effective and efficient leadership. It is reasonable to conclude that digital educational resources containing knowledge and practical experiences from these areas drive the integrated approach in professional development of the target audience. The design procedure for developing of digital educational resources for economic and managerial education of the master’s in IT students is important for the development of the qualitative professionals. The proposed design procedure consists of seven stages. Stage 1 includes pedagogical and technological aspects. Stage 2 is the problem definition. The problem to be solved by the development of digital educational resource, the goal and particular tasks are being defined on this stage. Stage 3 contains the task for the development of the digital education resource. Stage 4 incorporates detailed design of the content and external appearance of the digital educational resource. Stage 5 represents interactive development and testing. Interactive processes allow progressive improvements and adaptation of the resource. Stage 6 requires start of pilot implementation and assessment of effectiveness. Stage 7 allows implementation of the digital educational resource, its interactive update and modification according to the feedback and usage results. Each stage of the procedure requires completion of the previous stages. At the same time an interactive nature of the stages of the procedure enables constant progressive improvement, update of the content and approaches used in the resource. Detailed planning and completion of the stages is needed for the success of the procedure.
Social Potential of Teachers in the Professional Environment
Authors: Kamińska Małgorzata
Published: April 2024

The article presents the results of a study on the social potential of teachers in a professional environment. Social potential was understood as intangible resources of commitment, trust, norms of reciprocity and networks of personal connections among teachers that enable cooperation and exchange of knowledge. The research concept was based on the theory of social capital, which has been popular for some time in economics and politics, but also in the social sciences.

It is clarified that in the education system in the current conditions of formation of a new information society, the role and importance of the teacher’s social potential is increasing. Therefore, the work of a modern teacher takes place in the context of the expectations that society places on him or her. The study distinguished four main variables: participation and cooperation, interpersonal relationships and communication, trust and credibility, reciprocity and loyalty. The results reveal the division of the respondents into two groups. The first of them are teachers who, in their assessments, create a positive image of their own social potential, especially in the case of participation, involvement and cooperation. The second group are teachers who are more skeptical and ambivalent. This is especially visible in the dimensions of reciprocity and loyalty as well as relationships and communication. Teachers do not strive to evaluate their own environment negatively. Perhaps they do not notice or do not want to notice uncomfortable, difficult or conflicting issues. It can therefore be assumed that this is a confirmation of the façade and superficiality of behavior and relationships among teachers, and the desire to maintain a safe status quo.
TRACES OF A STAGE POEM IN “WOE FROM WIT”
Authors: Nikishov Yury
Published: March 2024

An analogy helps here: Griboedov was influenced by Goethe's “Faust”. The stage poem most noticeably differs from dramatic compositions by the organization of the stage action, by the system of images, and by the degree of the conventionality of the image. Griboedov also showed the playwright's mastery; however, he completed “Woe from Wit” in a nontypical way for a comedy - with an open ending. Traditional seeing Chatskii as a victorious fighter neglects the depth of the revelation. It takes an extraordinary mind to see the inevitability of human loneliness in a divided world. “I live and I write both freely and freely,” Griboedov replied to criticism. The stage poem provided more place for freedom. After “Woe from Wit” he wrote the tragedy “Georgian Night”, the evil spirits of Georgia involved. Portraying them on stage would be difficult, the readers' imagination is more effective. The fantastic component allows an individual conflict (of the prince and his long-term wet-nurse) to be brought to the level of the universe. Unfortunately, only two fragment drafts of the finished tragedy remained. Griboedov did not want to become a professional writer. After a short period of apprenticeship, he took up the pen to commit his worldview discoveries to paper for himself in an artistic form. His death on the rise is a great loss for Russian literature.
PRIVATE CORRESPONDENCE OF GRIBOEDOV
Authors:   Russian presidential Academy of national economy and public administration (RANEPA), Tereshkina Darja
Published: March 2024

Neither the letters of A.S. Griboedov as a complex source nor his ego-documents, the analysis of which is important for understanding the writer's worldview, nor his communication strategies with recipients have been the subject of a special study until now. Undoubtedly, as a person and writer, Griboedov is clearly expressed not only in his literary works but also in private letters to friends, colleagues, the Emperor, his wife, and others. In the correspondence of this great contemporary of Pushkin, which is preserved to the present day, a rich repertoire of speech tools is of interest, as well as a wide range of topics (not only everyday ones) and the palette of emotions expressed by Griboedov in relation to each recipient. Also noteworthy are the non-linguistic parameters of creating a particular letter: the time and the place of writing, the circumstances, the gap in the time of the beginning and end of writing the message (it took place on several occasions with Griboedov). Some of the letters contain detailed narratives about the events that accompanied Griboedov's life. Being one of the most intimate sources, letters reflect not only the richness of the writer's personality but also the multidimensional nature of his role as a communicant in written communication.
ITALIAN TRANSLATIONS OF THE COMEDY “WOE FROM WIT”
Authors:   Bari State University “Aldo Moro”, Caratozzolo Marco
Published: March 2024

The article focuses on the history of Italian publisher's interest to A.S. Griboedov's life and works in the last hundred years. Special attention is given to the Italian translation of “Gore ot Uma” with some interesting details about the specialists of Russian literature who translated the comedy text. As a result of this investigation, we can say that in Italy Griboedov's comedy enjoyed great interest, especially in relation to performances inspired to it. On the contrary, it is to say that very few researches have been published in Italy on Griboedov and the most important essays about him are the same introductions to the new editions.
“WHAT A WOE TO THE MIND OF GRIBOEDOV - DIRECTOR'S WOE-ODDITIES”. VS. MEYERHOLD'S PERFORMANCE “WOE TO THE MIND” REVIEWED BY DEMYAN BEDNY (BASED ON ARCHIVAL MATERIAL OF IWL RAS)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Fedorov Maksim
Published: March 2024

The article analyzes two epigrams written by Demyan Bedny after watching the legendary performance “Woe to the Mind” by V.E. Meyerhold on archival documents of IWL RAS. An attempt is made to outline the theatrical preferences of the proletarian poet, to show how, using the example of the Maly Theater, the poet in his work created the image of an ideal theater group. The research focuses on the analysis of the relationship between “the red director“ and Demyan Bedny. It is known that the poet did not miss the high-profile premieres of Meyerhold and responded to them with poems and epigrams. Especially acute was the clash between the poet and the director after the premiere of “The Government Inspector”. Then the emigrant critics remembered Demyan Bedny and took him as an ally. The conflict between the poet and the director continued after the premiere of “Woe to the Mind”. At a certain period in the life of such different artists, a common work could unite, but it was not implemented. The article opens an unknown page in the insufficiently studied topic “Demyan Bedny and the theater”.
THE PROPERTY OF THE BELKIN NOBLES IN THE VYAZEMSKY UYEZD
Authors: Gurskaya Natalia
Published: March 2024

The State Historical, Cultural and Nature Museum-Reserve Named after A.S. Griboedov “Khmelita” includes the village of Bogoroditskoye which was owned by the Belkins from 1807 to 1860. The work is devoted to the study of the history of this genus, its connection with the Vyazma land. Archival materials of St. Petersburg, Moscow, Smolensk made it possible to trace the Belkin family tree from the 18th century. The genus is mainly associated with the Kaluga lands, but some representatives of the Belkin left their mark on the Vyazma land. The history of other Belkin estates is traced: Rizskoe, Vladimirskoe, Bogoroditskoe, along the female line of Volochek, Ovinovschina, Bogdanovschina. The presented material acquaints with individual representatives of this genus, their kinship and family ties are considered.
FROM THE HISTORY OF THE VLADIMIR BRANCH OF THE GRIBOEDOV FAMILY
Authors:   Local History Museum of the Kovrov district of the Vladimir region, Frolovа Ella
Published: March 2024

The genealogy of the Vladimir branch of the Griboedov family is known from the first half of the 17th and mid-19th centuries. The pedigree painting includes 8 generations and 34 representatives. The Griboedov genus was included in the 6th part of the noble pedigree book of the Vladimir province in 1792. The article analyzes the affinity of the Griboedov family with other surnames of the Vladimir nobility, established on the basis of previously unknown documents of the State Archives of the Vladimir region. The estates of the Griboedovs in the Vladimir province were located in Vladimirsky, Suzdal, Vyaznikovsky, Gorokhovetsky, Kovrovsky, Pokrovsky and Sudogodsky districts. Particular attention is paid to the discovery of the tombstone of A.S. Griboedov's great-aunt Anna Griboedova in the Kovrov district of the Vladimir region. The found monument is located near the Nikolsky church of the village of Alachino, Kovrovsky district, in the parish of which the village of Vysokovo was located, where A.V. Griboedov, married Trusov. To date, this is the only surviving tombstone of a representative of the Griboedov family in Russia.
УДОСКОНАЛЕННЯ ОБЛІКОВО-КОНТРОЛЬНОГО ЗАБЕЗПЕЧЕННЯ ЕКСПОРТНО-ІМПОРТНИХ ОПЕРАЦІЙ ПІДПРИЄМСТВ
Authors: Калінеску Тетяна , Мартиненко Катерина
Published: April 2024

The article examines accounting and control support for export-import operations of enterprises in the context of management accounting of these operations. It was determined that today there are problems with the accounting of information on the costs of export-import operations, which do not allow enterprises to fully calculate the effectiveness of conducting foreign economic activities.

Each enterprise implements management accounting personally, the current legislation allows adding new ones to the list of sub-accounts with preservation of sub-account codes according to the Chart of Accounts, based on the needs of management, control, analysis and reporting of the enterprise. This measure will allow the enterprise to receive more detailed, specific information, which will help the management staff in planning, analysis and control of the accounting and control support of export-import operations, to make decisions, for the effective implementation of their activities.

As a result of the study of the problems of accounting and control support for export-import operations, additional accounts for accounting of income and expenses of foreign economic activity, which will be kept according to geographical and economic segments, as well as an algorithm for the formation of a corresponding management report on financial results, which reflects these additional incomes and additional expenses, are proposed arising during the implementation of this activity. According to the given algorithm for calculating the absolute and relative efficiency of the enterprise's export activity, in the future it is possible to calculate the absolute and relative efficiency of each individual export operation, which will provide the necessary information for the process of making managerial decisions regarding the selection of the most effective types of products.

Thus, the effectiveness of the export operation is determined not only by the amount of costs incurred by the exporter during the operation, but also by other factors, including the correct determination of the customs value, which depends on the amount of taxes paid.
GENESIS OF CONCEPTUAL APPROACHES TO «LOGISTICS» CATEGORY
Authors: Reikin Vitalii
Published: April 2024

Abstract. The article deals with the current theoretical and methodological approaches to foming «logistics» category, which is considered as a science and a practical area of business. A retrospective and development evolution of the researched category in military, mathematical and economic aspects is given. Attention is drawn to the fact that in economic science, the genesis of  «logistics» category is closely related to forming market relations in industrialized countries. Three main conceptual approaches were studied, which form the definition of the term «logistics» and generally determine the directions of further scientific developments, the nature of  logistics use in practice: associativity with material and technical support of production and other types of activities, sales of products; scientific organization of managing infrastructural flow processes by means of their integration, optimization of costs and rationalization of production processes; scientific organization of managing any flow processes in any sphere of human activity. A critical analysis of the considered approaches was carried out from both a scientific and a practical point of view. The differences of F. Kotler's ideas on market logistics compared to mainstream approaches in the marketing aspect are outlined. The interrelationship of the theory, methodology, object and subject of logistics with certain types of activities, material and goods and related information and financial flows is stated. Attention is focused on the dominant paradigmatic idea – global integration and optimization of flow processes. It is justified that the development of information technologies had the greatest impact on logistics, and logistics itself is now increasingly influencing the development of various spheres of human activity. The genesis of approaches to «logistics» category is summarized: stages, conceptual features and definitions of examined term. It was concluded that in modern conditions, logistics is mainly aimed at increasing the efficiency of integration of any flow processes that have features of spatio-temporal sequence, therefore attempts to globalize logistics fields of application not only in the economy, but also in the science in general, culture, and art etc. are natural.
ФІНАНСОВИЙ АСПЕКТ БАГАТСТВА ЛЮДИНИ І НАЦІЙ
Authors: Євтух Олександр
Published: April 2024

Introduction. The article is devoted to important problems: what are the origins of people's wealth and inequality, why do some nations decline and others become richer?

The purpose of the article.. The purpose of the article: on the basis of a systematic approach to problems and a new interpretation of the basic law of value, the principle of its growth, and the fundamental provisions of the theory of finance, to shed light on the nature of the wealth of mankind.

Results.The article examines the approaches of scientists from different countries, regarding their answers to today's questions and the substantiation of their conclusions. On the basis of a systemic approach, the nature and causes of the wealth of people and nations were investigated, and the contribution of scientists to the solution of existing problems was analyzed.

  It is substantiated that there were and will be many reasons for wealth, and they are always interconnected. The nature of wealth remains the same - the desire of people to create and circulate value in order to satisfy their needs and the needs of nature. A study was conducted using the law of value and the fundamental provisions of the theory of finance, which showed that trust and responsibility between people, the state and nature were and are the basic principle of wealth.

It is outlined that trust and responsibility are a manifestation of a person's worldview, when a person not only understands the need to be trustworthy and responsible, but also feels such a need. Trust and responsibility, as a manifestation of human consciousness, is formed by many factors: geographical, climatic, political, national, family, pedagogical, psychological, spiritual, as well as education, availability of natural resources, technological progress, legal and moral norms, and others

The article analyzes the problems of increasing wealth in Ukraine and highlights the ways of its growth. An attempt was made to make a scientific forecast of the growth of the wealth of mankind in the information age.

Conclusions It is proven that during the transition to the information age, which has already begun, the worldview of the population of the countries and the world scientific paradigm are changing, which creates for scientists a new foundation for researching the problems of wealth development. However, the nature of wealth remains the same: trust and responsibility between people and man towards nature. Trust-responsible relationships are a manifestation of a person's worldview.
Eficiencia en las entidades públicas en México por el ejercicio efectivo de la Auditoría Gubernamental
Authors: Barquera-Garza Roberto , Barrera-Guerra Jr Juan Lorenzo
Published: March 2024

La Auditoría Superior de la Federación en México (ASF) es el órgano fiscalizador encargado de revisar la cuenta pública de la federación año con año, verificando que los recursos federales sean utilizados de manera correcta por las dependencias públicas, esto cumpliendo con las Leyes y reglamentos aplicables. La ASF le reporta sus hallazgos a la Cámara de Diputados del Congreso de la Unión, analizando los informes generales ejecutivos emitidos, notamos recurrencia en hallazgos durante 3 años y analizando los fundamentos de auditoria se determinó que el establecer acciones correctivas claras, responsables y fechas límite para cerrar los hallazgos podría fomentar la gestión eficiente de la ASF.  Por lo que en estudio se consideró como solución para mejorar la eficiencia del control interno el aplicar acciones correctivas claras.
Hate speech and cancellation phenomena and the impacts on young people's communication in digital environments.
Authors: Silva Daniela , Borges Jussara
Published: April 2024

The ICT Domicílios 2021 survey reveals the growth in the use of the internet in Brazil compared to periods prior to the Covid 19 pandemic. However, this expansion is not reflected in the percentages of selfauthored content posted by users: only 31% reported that they share something of their own creation, be it a text, image, photo, video or music. Among young people from Salvador (Bahia, Brazil) who are interested in politics, Silva's research (2022) revealed that only 34% claim to publish authorial content. Among the reasons given by young people, they mention fear of cancellation and hate speech. This article analyzes data from this survey in the light of discussions on infocommunicative literacy. We conclude that public policies in the country need to advance in terms of guaranteeing the right to the internet associated with education for the ethical, critical and democratic use of information and communication.
Comparison of Oral Glcose Tolerance Test and HOMA-IR in Screening for Gestational Diabetes Mellitus in Pregnant Women
Authors: KANAT Burak , TOPAL Kenan , AKSOY Hüseyin , KANAT Aysenur , GEREKLIOGLU Cigdem
Published: March 2024

Comparison of Oral Glcose Tolerance Test and HOMA-IR in Screening for Gestational Diabetes Mellitus in Pregnant Women Aim: The Oral Glucose Tolerance Test (OGTT) is used for the screening of Gestational Diabetes Mellitus (GDM) and
is a difficult test for some patients to tolerate. Insulin resistance (IR) can also be checked in pregnant women by using the fasting glucose and fasting insulin values. In this study, we aimed to compare the effectiveness of OGTT
and HOMA-IR for GDM screening in pregnant women. Methods: This cross-sectional study was carried out on all pregnant women who underwent GDM screening at the Adana City Training and Research Hospital between April 1 and June 30,
2021. Sociodemographic data were recorded and anthropometric and blood pressure measurements were made. In addition to OGTT with 75g glucose, the HOMA-IR results were also recorded. The cut-off value for IR was 2.4. Results: The
mean age of the 107 participants was 29.2±5.7 years. According to the OGTT, 32 (29.9%) had GDM, and according to the HOMA-IR 27 (25.2%) had IR. Among the 32 women diagnosed with GDM according to the OGTT, 17 (53.1%) had no insulin
resistance (HOMA-IR˂2.39), while 15(46.9%) had insulin resistance (HOMA-IR>2.40), (p=0.002).In women with and without GDM, there was no significant difference in pre-pregnancy weight and BMI, and current weight and BMI. However,
pre-pregnancy weight and BMI, and current weight and BMI were found to be significantly higher in pregnant women with IR compared to those without IR. Conclusions: Detection of IR with HOMA-IR in pregnant women can be helpful in
revealing additional findings when used together with OGTT and may be useful in patients who do not want or cannot tolerate the OGTT.
Is Comorbidity or Age Important in the Hospitalization Decision in COVID-19 Patients? A Case-Control Study
Authors: Sogukpinar Ozlem , Ernam Dilek , Yildiz Tekin , Akturk Ulku Aka , Karakurt Zuhal , Gungor Sinem , Group: COVID interest
Published: March 2024

Aim: COVID-19 is an important problem, and comorbidities may worsen the course of the disease. We aimed to investigate the role of comorbidities in COVID-19 patients hospitalized for outpatient treatment failure. Methods: Hospitalized
COVID-19 patients were included in this study between March 1 and May 15, 2020. Those hospitalized due to treatment failure were defined as Group-1, and those hospitalized at first admission were defined as Group-2. Demographic
information, comorbidities, laboratory data, and clinical results of the patients were examined. Results: A total of 514 patients were included in the study; 19.3% (n=99) were patients who worsened despite outpatient treatment
(Group-1), and 80.7% (n=415) were hospitalized at first admission (Group-2). Group-1 cases were younger, but comorbidities were as high as the older Group-2 cases. We found that increasing age increases the risk of hospitalization
(OR=1.02), bronchiectasis reduces the risk of hospitalization (OR=0,109), and other comorbidities have no impact on the risk of hospitalization. There was no difference between groups according to ICU transfer (Group-1: 6.1%, Group-2:
9.2%, p=0.32), hospital discharge rates (Group-1: 100%, Group-2: 96.6%, p=0,064), and mortality rates (p=0.064). In Group-1, leukocyte, thrombocyte, neutrophil, lymphocyte, eosinophil, monocyte, and basophil values were lower,
and urea and D-Dimer values were higher than Group-2. Conclusions: This study identified age as a factor in increasing hospitalization in COVID-19 patients. On the other hand, the presence of bronchiectasis in patients appears
to be a factor in reducing hospitalization. This situation raises a new question about whether the permanent dilation resulting from the damage caused by bronchiectasis in the bronchi could act as a preventive factor for the coronavirus.
We believe that well-designed studies involving a large case series could lead the way in exploring this aspect further.
Quantitative analysis of rutin in flavonoid-rich plant raw material by HPTLC
Authors: Kobakhidze T.I. , Agatonovic-Kustrin S. , Gegechkori V.I. , Chugaev D.V. , Ramenskaya G.V.
Published: March 2024

Introduction. Due to the increasing requirements for the quality of pharmaceutical products, the requirements for standardization of herbal medicines are also growing, which in turn necessitates the development of approaches to quality control of medicinal plant raw materials. The use of such an advanced method as high-performance thin-layer chromatography (HPTLC) will improve the quality of drug standardization, which is associated with the advantages of this method: minimized sample preparation, parallel determination of small volumes, elution time, high sensitivity, efficiency and speed. Objective. Quantitative determination of rutin by high-performance thin-layer chromatography, as well as comparison of the results of quantitative determination of the amount of flavonoids in terms of rutin by the spectrophotometric method. Material and methods. Medicinal plant raw materials – violet herb – were subjected to extraction using a developed method with 70 and 96% ethanol. Quantitative determination of rutin in extracts was carried out by HPTLC and spectrophotometry. Results. The developed method for the quantitative determination of rutin was validated in terms of linearity, specificity and accuracy. The difference in the extractive ability of the solvents used was shown. The percentage of rutin determined using the HPTLC method in an ethanol (96%) extract (3 µl) is 3.0826%, in an ethanol (70%) extract (3 µl) – 1.5911%. The percentage of rutin determined using the HPTLC method in an ethanol (96%) extract (5 µl) is 3.0894%, in an ethanol (70%) extract (5 µl) – 1.6064%. The percentage of total flavonoids in terms of rutin determined using the spectrophotometric method in the ethanol (96%) extract is 3.4289%, in the ethanol (70%) extract – 2.4176%. Conclusion. As a result of the study, a method for the quantitative determination of rutin was developed and validated, which can be used in the standardization of violet herb.
Comparative study of morphological and anatomical features of Bidens L. Species
Authors: Rodin M.N. , Baeva V.M. , Bokov D.O. , Voronov V.M. , Samylina I.A.
Published: March 2024

Introduction. Determining closely related impure species when confirming the authenticity of medicinal plant raw materials (mprms) is a very difficult and controversial task, especially for crushed and powdered mprms. One of such objects is the three-part beggarticks, which is prone to polymorphism and occupies the same area with the nodding beggarticks, the Spanish needles and the devil's beggarticks. Objective: to conduct a comparative pharmacognostic analysis of species of the genus Bidens L., which can be collected together with the pharmacopoeial species – three-part beggarticks. Material and methods. The objects of study were dried herbs of three-part beggarticks (Bidens tripartita L.), nodding beggarticks (Bidens cernua L.), Spanish needles (Bidens bipinnata L.), and devil's beggarticks (Bidens frondosa L.), collected in the Moscow region in 2020–2021. In this work, we studied the anatomical and morphological structure of leaves, as the most preferred part from a diagnostic point of view. The study of anatomical and morphological characteristics was carried out in accordance with the General Pharmacopoeial Monograph of the Russian Federation State Pharmacopoeia XIV 1.5.1.0003.15 “Leaves”. Results. A comparative description of the anatomical-diagnostic external and microscopic characteristics of the Bidens leaves has been obtained. Bidens tripartita and Bidens frondosa are higher than others. In contrast to the impure species, the Bidens tripartita has the largest deeply trifid, irregular serrated leaves, more pronounced tortuosity of the epidermal cells of the upper side of the leaf, multicellular thin-walled caterpillar-like and simple thick-walled hairs are combined, and the secretory canals in the mesophyll located along the vein. Conclusion. Among the studied Bidens species, each has characteristic features of its morphological and anatomical structure. These specific features can be used to establish the authenticity of the mprms and distinguish it from impure Bidens species, which require further research.
Composition of biologically active substances of common cranberry fruits (Oxycoccus palustris Pers.) in various methods of preservation
Authors: Sergunova E.V. , Malysheva M.O. , Morokhina S.L. , Samylina I.A.
Published: March 2024

Introduction. The study of common cranberry fruits is promising due to the wide variety of biologically active substances included in their composition, a wide range of therapeutic properties, as well as the ability of cranberry fruits for long-term storage and resistance to harsh environmental conditions. Fresh fruits contain the maximum amount of biologically active substances and, accordingly, have the most pronounced pharmacological effect. To preserve the composition and content of biologically active substances, preservation is used in pharmacy. Most often they resort to drying. Freezing can be considered a new and promising method for preserving the quality of medicinal plant materials. Purpose of the study. Study of the effect of freezing and drying on the qualitative composition and quantitative content of biologically active substances in common cranberry fruits. Material and methods. The object of the study was fresh, frozen, and dried common cranberry fruits collected in the Pskov and Novgorod regions in 2022 during the fruiting period. The study of the composition of biologically active substances (BAS) and quantitative assessment of the content were carried out according to pharmacopoeial methods, using analysis using thin layer chromatography (TLC), spectrophotometry and redox titration methods. Results. Using TLC analysis, organic acids (ascorbic, malic, citric, tartaric and succinic), flavonoids (rutin, quercetin), tannins (gallic acid) and anthocyanins were identified in the fruits. There were no differences in the qualitative composition of dried and frozen fruits. The content of organic acids, tannins, flavonoids and anthocyanins in cranberry fruits using different preservation methods was determined. It has been established that when fruits are dried, the content of all studied groups of biologically active substances decreases, on average by 40–60% of the initial content in fresh raw materials. Ascorbic acid is destroyed to a greater extent (90–92%). Exposure to low temperatures leads to a slight decrease in biologically active substances in common cranberry fruits (7–14%). Conclusion. The influence of preservation methods on the composition and content of biologically active substances in common cranberry fruits has been studied. The possibility of using frozen cranberry fruits as an alternative to fresh and dried raw materials in the manufacture of drugs in allopathy and homeopathy has been shown.
Determination of quality indicators of a combined nootropic drug
Authors: Abdunazarov A.I. , Tashpulatova A.D.
Published: March 2024

Introduction. The state drug policy of the Republic of Uzbekistan is aimed at the release of new affordable import-substituting drugs of domestic production, which are not inferior in activity to foreign analogues. Taking this into account, and also taking into account the high cost of imported nootropic drugs, the pharmaceutical production of LLC «Тemur med farm», Syrdarya region, Uzbekistan has developed the composition, technology and production of the combined drug "Nootrotem". "Nootrotem" is a combined preparation of piracetam and methylethylhydroxypyridine succinate in an injectable dosage form. Based on preclinical pharmacological studies, the pronounced nootropic and metabolic effects of the studied drug have been proven. Objective: The purpose of these studies is to develop quality assessment methods and establish quality indicators of the combined drug "Nootrotem" solution for infusions. Material and methods. 5 series of laboratory samples of the drug "Nootrotem" solution for infusions obtained at the pharmaceutical production "Temur med farm", Uzbekistan, were used as research objects. Results. The determination of the quality indicators of the studied drug was carried out in accordance with the modern requirements of the National pharmacopoeia of the Republic of Uzbekistan and the European pharmacopoeia, as well as in accordance with the general technical regulations on the safety of medicines. Conclusion. As a result of the conducted research, the main quality indicators of the drug "Nootrotem" solution for infusions were established according to the following indicators: description, authenticity, transparency, chromaticity, pH, package filling volume, mechanical inclusions, impurities, residual sulfur dioxide, osmolality. The limits of their rationing have been established in accordance with the State Budget of the Republic of Uzbekistan.
MODERN DRUGS FOR NUTRITIONAL SUPPORT OF THE PATIENT
Authors: Morozov A.M. , Sergeev A.N. , Askerov E.M. , Drozdova D.A. , Markova P.D. , Khodzhaeva S.E.
Published: March 2024

Introduction. Nowadays, nutritional support is an integral part of the management of patients in hospitals of any profile. Parenteral nutrition (PN) is a vital therapy and is indicated in those situations when enteral or oral nutrition is impossible or insufficient, for example, in such clinical conditions as advanced variants of Crohn's disease and ulcerative colitis, stenotic deformities of the esophagus, comatose change of consciousness, cancer cachexia, neuropathies of various etiologies, and others. The aim of the present study was to investigate preparations for parenteral nutrition as part of an integrated approach to the treatment of various pathologic conditions. Parenteral nutrition is in modern clinical medicine an integral part of adequate treatment in the presence of protein-energy deficiency in patients. Currently, there are many nutrient mixtures that can compensate for nutrient losses in various pathologies. There are standard systems that can compensate for substrate deficiencies individually, but the most effective are considered to be 3-in-1 systems, which are more harmonious and balanced in their composition, which, in turn, leads to the fullest satisfaction of the nutrient needs of patients. Conclusion. At the same time, it is necessary to take into account that in case of irrational use, the risks for the patient increase, therefore, in order to mitigate them, it is necessary to implement programs to control the production of mixtures and assess their qualitative and quantitative composition.
STATINS IN THE TREATMENT OF PATIENTS WITH PERIPHERAL ARTERY DISEASES: STRATEGY AND TACTICS OF APPOINTMENT
Authors: Paranina E. , Krivoshchekov E. , Paranin P.
Published: March 2024

The article presents a review of the literature on the relationship of peripheral artery diseases and cardiovascular complications. According to modern concepts, peripheral artery diseases are classified as markers of very high cardiovascular risk. The most important aspect of the therapy of patients in this category, in addition to correcting specific symptoms of vascular lesions of the lower extremities, is to reduce the risk of developing cardiovascular diseases and their prevention, and treatment of patients in this category should be carried out in accordance with the recommendations for secondary prevention of cardiovascular complications, the most important part of which is the control of serum lipids. Statins are the most widely used class of drugs for the correction of hypercholesterolemia, but the frequency of their appointment as a strategically important class of drugs to prevent the development of atherosclerotic cardiovascular complications in high- and very high-risk individuals in the Russian Federation, as in other countries, remains low. The basic principles of lipid-lowering therapy in patients with peripheral artery diseases are described: strategies, goals and issues of therapy control.
Ultrasonic vascular visual-exercise early diagnosis of arterial hypertension
Authors: Avkhimenko V. , Trivozhenko A.
Published: March 2024

High level of prevalence of the arterial hypertension (AH) demands use of new technologies of early disease verification. Purpose. Develop a visual-exercise method of diagnostics of AH: bicycle-stressful doppler sonography of a renal-vascular blood-groove with assessment of the vascular motion status and definition of diagnostic criteria of disease. Materials and methods. The cohort (n=48) of healthy subjects and patients with AH I-II degree is surveyed. Bicycle-stressful research of renal-vascular reactivity included initial measurement and exercise monitoring of peak speed of a blood-groove (Vps) and the resistant index (RI) in renal artery (RA). Calculation the index of the pressor and high-speed relation (IPHSR) on a formula was carried out: IPHSR = Systolic BP/ Vps RA. Results. At peak bicycle-stressful test the VpsRA at patients with AH increased only 8% (2.8–11.0%) while at healthy volunteers – 27% (21.4–37.0%). Significantly differed IPHSR: at patients with AH it was measured 2.38–3.23 units (2.8 [2.650–2.892] units), and healthy volunteers 1.72–2.37 units (2.03 [1.91–2.16] units) (p=0,0001). The sensitivity of IPHSR was 91%, specificity – 88%, accuracy – 93%. The decrease of cortically kidney perfusion (increase in RI RA) in group of control was less expressed, than group of patients with AH: 8,6% (4.3–11.0) and 14.7% (9.7–23.2] respectively (r=0,0004). Conclusion. In the course of bicycle-exercise at patients with AH load the small growth of peak speed (25%), the IPHSR is highly sensitive (91%) and highly specific (88%) criterion of AH with differential border of 2,5 units.
The prevalence of non-communicable diseases among working women
Authors: Amlaev K. , Blinkova L. , Dahkilgova Kh. , Mazharov V.
Published: March 2024

Non-communicable diseases are the main problem of modern society. This review represent data on chronical diseases and their risk factors among working women. It also describes the global trends of main risk factors among working young women and the manifestation of non-infectious diseases, including coronary heart disease, overweight/obesity, arterial hypertension, diabetes mellitus and mental health problems. Long working hours, workload and stress at work were identified as the risk factors of non-communicable diseases. The double burden of work and household duties increased the risk of non-communicable diseases among working women in comparing with working men. State-level strategies were proposed to improve the situation of reducing the prevalence of non-communicable diseases and their prevention. For example, the strategy for the prevention of chronical pathology among working women, included the search of risk factors, strengthening of health policy, the interventions at the working place, including adherence to timetable, the balance between work and personal life.
ROLE OF URIC ACID IN CLINICAL MANIFESTATIONS OF ANKYLOSING SPONDYLITIS
Authors: Bazina I. , Krechikova D. , Kozyrev O. , Pavlova M. , Rostkova D. , Konevskikh M. , Mukhina A.
Published: March 2024

Prevalence of ankylosing spondylitis (AS) is about 0.2–0.8% and increasing during last decades in Russia. Coronary Heart Disease (CHD) plays an important role in mortality in patients with rheumatic diseases. AS mainly affects able-bodied age persons thus having a significant social and economic impact. There plenty of biomarkers of AS, including those for early diagnosis.
Purpose. To study the level of uric acid (UA) in patients with AS and its role in development of AS.
Materials and methods. A total of 72 medical charts of patients hospitalized at Smolensk Regional Rheumatological Center were evaluated, among them 73.6% were men and 26.4% – women. AS was diagnosed according to classification criteria. Lab tests were done in a central lab using standard methodology. All data collected for each patient was entered into an Excel spreadsheet and analyzed.
Results. Average patients age was 49.6±12.4 years. BMI was 28.1±5.4 kg/m2. Arterial Hypertension (AH) and CHD was diagnosed in 44.4% of patients. Glomerular Filtration Rate (GFR) was 95.1±21.9 mL/min. UA concentration were equal to 301.3±94.3 mmol/L, total cholesterol (TC) – 5.0±1.0 mmol/L, CRP – 60.5±35.1 IU/L. A direct correlation between CRP and BMI was revealed (p<0.005). UA concentration in patients with AS and CHD was 347.3±73.9 mmol/L, while in patients with AS without CHD it was significantly lower: 261.8±77.4 mmol/L (p<0,001). UA concentration in patients with AS and HLA-B27(+) was 345.1±90.8 mmol/L, in patients with AS and HLA-B27(-) – 259.1±75.1 mmol/L (p<0,001). BASDAI in patients with AS was equal to 5.7±2.1. UA concentration in patients with mild to moderate AS was 255.4±77.7 mmol/L; severe AS – 343.4±75.3 mmol/L (p<0.001). Correlations between TC level and BASDAI (p<0.05) as well as between UA level and BASDAI (p<0.05) were revealed.
Conclusion. In patients with AS increased level of UA supports inflammation activity, forces subjective symptoms of the disease (pain), correlates with disease activity and BASDAI. Hyperuricemia increases risk of CHD, worsens prognosis of AS. UA may be considered as a biomarker of disease activity and prognosis of AS, atherosclerosis and cardiovascular diseases
Modern ideas about concentric sclerosis Balo: a clinical case
Authors: Mnatsakanyan G. , Raevskaya A. , Vyshlova I. , Karpov S.
Published: March 2024

Balo's concentric sclerosis (BCS) is a rare demyelinating disease of the central nervous system, characterized by concentric areas of demyelination alternating with areas of preserved myelin in the form of a pathognomonic pathomorphological substrate of varying degrees of severity in the form of «annual rings on a tree cut». The pathogenesis of BCS is diverse and complex, today there are several theories of its occurrence, among which hypoxic, vascular and closely related genetic, as well as a number of other theories are distinguished. The BCS clinic is variable, represented by both focal neurological manifestations and general cerebral symptoms. The diagnosis is based on the data of magnetic resonance imaging of the brain. The drugs of choice for BCS therapy are glucocorticosteroids (prednisolone or methylprednisolone).
Treatment of a multimorphic form of vertebral infection (clinical case)
Authors: Yarikov A. , Perlmutter O. , Fraerman A. , Simonov A.
Published: March 2024

A clinical case of surgical treatment of a patient with a multimorphic form of vertebral infection is presented (spinal epidural abscess, paraspinal abscess, subdural epiema, iliopsoitis, purulent meningitis, complicated by sepsis and bilateral pneumonia). The patient underwent three surgical interventions and underwent targeted antibacterial therapy.
Optimization of pathogenetic therapy of patients with tick-borne rickettsiosis caused by rickettsiae heilongjiangensis in Khabarovsk Territory
Authors: Mokretsova E. , Tomilka G. , Kovalskiy Yu. , Schupak A. , Golubkina N. , Maleev V.
Published: March 2024

Objective. To study the dynamics of selenium level and some indexes of oxidative status of blood serum in patients with the moderate form of tick-borne rickettsiosis caused by Rickettsiaе heilongjiangensis, in Khabarovsk Region, depending on the treatment in order to optimize the pathogenetic therapy. Materials and methods. Comparative analysis of combinations of treatment by basic means (antibiotics, detoxication therapy) and in combination with organic selenium was carried out on the basis of determination of nutrient selenium level and some parameters of oxidative status in blood serum of patients with tick-borne rickettsiosis determined by R. heilongjiangensis without accompanying chronic diseases at decompensation stage. Results. The daily dosage of «paprika» powder at a dose of 60 mcg/day allowed to level the selenium deficiency to a suboptimal level of supply. Besides, analysis of chemiluminescence of blood sera of patients who received organic selenium as a part of complex treatment showed activation of antioxidant antiradical protection and decrease of free radicals production against the background of improvement of clinical status. Conclusions. Thus, the complementary therapy with organic selenium promotes normalization of antioxidant protection processes and reliably restores suboptimal provision of selenium and can be recommended for treatment of tick-borne rickettsiosis patients caused by R. heilongjiangensis.