bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical findings in patellofemoral osteoarthritis compared to individually-matched controls: a pilot study
Authors: Macri Erin M , Crossley Kay M , Hart Harvi F , d’Entremont Agnes G , Forster Bruce B , Ratzlaff Charles R , Wilson David R , Khan Karim M
Published: December 2020

Objective

To explore clinical characteristics in individuals with patellofemoral osteoarthritis (PFOA) compared to individually-matched asymptomatic controls. We also explored associations between functional performance and patient-reported symptoms with patellofemoral alignment.

Methods

We assessed 15 individuals with PFOA and 15 individually-matched asymptomatic controls. In addition to physical examination and patient-reported questionnaires, we evaluated functional performance, lower extremity strength and range of motion, and patellar alignment (using MRI). We analysed group differences with Wilcoxon’s matched-pairs signed rank tests, and within-group associations with Spearman’s rank correlations.

Results

We included 24 (80%) women with median (IQR) age of 56 (9) years and BMI of 22.8 (5.9) kg/m2. Individuals with PFOA reported lower quality of life (8/100 points lower EQ-5D-5L, p=0.02), and performed worse on two functional tests: repeated one-leg rises (median 16 fewer rises, p=0.04) and timed stair climb (1.2 s slower, p=0.03). There were no differences in strength tests performed or range of motion. Patellar proximal translation correlated with worse functional performance and worse patient-reported pain, function and self-efficacy, while lateral translation and lateral tilt correlated with worse knee-related quality of life (Spearman’s r ranging from 0.5 to 0.7).

Conclusion

Functional performance was worse in individuals with PFOA, despite those individuals having no significant differences on lower extremity strength testing. Patellofemoral alignment was associated with worse functional performance as well as worse patient-reported outcomes, and it may represent one mechanism underpinning PFOA-related symptoms.
Light yield of cold undoped CsI crystal down to 13 keV and the application of such crystals in neutrino detection
Authors: Ding Keyu , Chernyak Dmitry , Liu Jing
Published: December 2020

The light yield of an undoped CsI crystal at about 77 Kelvin was measured to be $$33.5 \, \pm \, 0.7$$

33.5

±

0.7

 photo-electrons (PE) per keV electron-equivalent (keVee) in the energy range of [13, 60] keVee using X and $$\gamma $$
γ
-rays from an $$^{241}$$

241

Am radioactive source. Based on this experimental result, the performance of 10 kg cryogenic inorganic scintillating crystals coupled to SiPM arrays to probe non-standard neutrino interactions through the detection of coherent elastic neutrino-nucleus scatterings at the spallation neutron source, Oak Ridge National Laboratory, was examined in detail.
Low-Mismatch and Low-Loss Transformer-Based SPDT Switch with Switching Load Technique for 5G Applications
Authors: Quan Xing , Zhan Jinsong , Luo Jiang , Su Guodong , Wang Xiang
Published: December 2020

This paper proposes a switching load technique to improve the mismatch at outputs of the transformer-based single pole double throw (SPDT) switch, thus improving the insertion loss (IL) performance. A switch is introduced as the load of the primary inductor of the conventional transformer-based SPDT switch to improve the IL performance in transmission and receiving operation modes. A transformer-based SPDT switch is implemented with the switching load technique in TSMC 40[Formula: see text]nm CMOS technology. The transformer which has a symmetrical shape is implemented with the thick metal for low IL propose. The simulated results show that the proposed SPDT switch achieves a minimum insertion loss of 1.64[Formula: see text]dB and the IL is better than 2.2[Formula: see text]dB across the range from 24 to 35[Formula: see text]GHz. The proposed SPDT switch occupies a core area of [Formula: see text]m2and the return losses are better than [Formula: see text][Formula: see text]dB at 24–35[Formula: see text]GHz.
Universal factorization algebras of polynomials represent Lie algebras of endomorphisms
Authors: Behzad Ommolbanin , Nejad Abbas Nasrollah
Published: December 2020

The goal of this paper is to supply an explicit description of the universal factorization algebra of the generic polynomial of degree [Formula: see text] into the product of two monic polynomials, one of degree [Formula: see text], as a representation of Lie algebras of [Formula: see text] matrices with polynomial entries. This is related with the bosonic vertex representation of the Lie algebra [Formula: see text] due to Date, Jimbo, Kashiwara and Miwa.
Investigation of New Multi-Channel HEMT Based on InAs0.3P0.7/InP for Future Power Terahertz HEMT’s
Authors: Soufiane Derrouiche
Published: December 2020

In this paper, we perform the increase of cut-off frequency for a HEMT based on the InP substrate by the use of a new concept which can be presented by the use of a Multi-Channel (M-Ch) based on InAs[Formula: see text]P[Formula: see text]/InP. This concept leads to formation of two confining interfaces and also an added barrier in the channel level which in turn leads to enhance the confining conditions of charge carriers. The obtained cut-off frequency for the proposed HEMT based on InAs[Formula: see text]P[Formula: see text]/InP has reached the Tera-hertz range which is the best of all existing power technologies. This morphology of structure is the first power structure that has reached this frequency range due to the use of InAs[Formula: see text]P[Formula: see text] as the main channel, it has better transport proprieties compared to that of InP. The same task is for the drain current in which the proposed structure has shown a high value compared to the structure based on a single-channel (S-Ch) formed by InP due to increasing confining interface number where the booth interface InAlAs/InAsP and InAsP/InP are being used.
Noble metal enhanced photocatalytic activity of heterostructured TiO2 spheres with tunable interiors and shells
Authors: Qiu Bo , Xiao Xin , Zhang Min , Mao Yue , Liu Xiaoheng
Published: December 2020

Heterostructured TiO2 spheres with tunable interiors and shells were prepared by self-template technology. This structure is composed of a hollow shell and an inner core which can enhance light scattering in the hollow space and provide a large surface to generate sufficient active sites. Besides, the nanosheets grown on the shell layer not only increased their specific surface area, but also exposed more surface-active sites. The performance of photocatalysts was estimated by the RhB decolorization, and experimental results show that the photoactivity can be greatly improved by depositing noble metal nanoparticles. It improves the efficiency of charge utilization and enhances the overall catalytic performance from the three stages of charge carrier generation, separation and surface reaction. The strong metal–support interaction (SMSI) between the noble metal nanoparticles and the oxide support has been proven to inhibit the supported precious metal, one strategy for nanoparticle aggregation and growth. On the one hand, the nanoshells isolate the precious metal nanoparticles from each other, preventing the aggregation of metal nanoparticles.
SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload
Authors: Riley Hannah J. , Kelly Ryan R. , Van Laer An O. , Neff Lily S. , Dasgupta Shaoni , Baicu Catalin F. , McDonald Lindsay T. , LaRue Amanda C. , Zile Michael R. , Bradshaw Amy D.
Published: December 2020

Myocardial fibrosis and the resultant increases in LV and myocardial stiffness represent pivotal consequences of chronic pressure overload (PO). In this study, a murine model of cardiac fibrosis induced by PO was used to demonstrate a critical function of SPARC in bone marrow-derived cells that drives cardiac fibrosis and increases in cardiac macrophages.
The role of the endothelium in the hyperemic response to passive leg movement: looking beyond nitric oxide
Authors: Trinity Joel D. , Kwon Oh Sung , Broxterman Ryan M. , Gifford Jayson R. , Kithas Andrew C. , Hydren Jay R. , Jarrett Catherine L. , Shields Katherine L. , Bisconti Angela V. , Park Soung Hun , Craig Jesse C. , Nelson Ashley D. , Morgan David E. , Jessop Jacob E. , Bledsoe Amber D. , Richardson Russell S.
Published: December 2020

Passive leg movement (PLM) evokes a highly nitric oxide (NO)-mediated hyperemic response and may provide a novel evaluation of vascular function. The contributions of endothelium-dependent vasodilatory pathways, beyond NO and including prostaglandins and endothelium-derived hyperpolarizing factor, to the PLM-induced hyperemic response to PLM have not been evaluated. With intra-arterial drug infusion, the combined inhibition of nitric oxide synthase (NOS), cyclooxygenase, and cytochrome P-450 (CYP450) pathways did not further diminish the hyperemic response to PLM compared with NOS inhibition alone.
Effects of menstrual cycle and menopause on internal carotid artery shear-mediated dilation in women
Authors: Iwamoto Erika , Sakamoto Rintaro , Tsuchida Wakako , Yamazaki Kotomi , Kamoda Tatsuki , Neki Toru , Katayose Masaki , Casey Darren P.
Published: December 2020

The present study evaluated the effects of the menstrual cycle and menopause stages on the shear-mediated dilation of the ICA, a potential index of cerebrovascular endothelial function, in pre-, peri-, and postmenopausal women. Shear-mediated dilation of the ICA was increased from the low- to high-estradiol phases in naturally cycling premenopausal women and was reduced with advancing menopause stages. Furthermore, lower estradiol was associated with reduced shear-mediated dilation of the ICA, independent of age.
A Simplified Approach to Estimating the Collapsible Behavior of Loess
Authors: Wen Hua , Deng Songyin , Zhang Wei , Cheng Qiangong , Wu Jiujiang , Hu Dailin
Published: December 2020

Due to the particularity and complexity of loess, it is challenging to estimate its collapsible behavior numerically at present. This paper aims to propose a simplified approach, which is named as the modulus reduction method, to estimate the collapsible behavior of loess. For loess upon wetting, the modulus reduction method assumes that loess collapses as a result of strength reduction due to the additional stress induced by increasing bulk density. Thus, special attention is given to the confirmation and determination approaches of bulk density and deformation modulus of loess upon wetting. Subsequently, a comparative numerical analysis based on the modulus reduction method and the force‐water equivalent method, which is commonly used for the analysis of negative skin friction on piles in collapsible soil, is investigated. It turns out that the result obtained by the modulus reduction method is more consistent with the collapse mechanism of loess compared with that derived by the force‐water equivalent method. Finally, a case history concerning a published field test of loess upon wetting is studied, and the result shows that the simulated deformation characteristics by adopting the modulus reduction method agree excellently well with the measured data. The case study validates that the modulus reduction method is feasible to analyze the collapse of loess and suitable for the numerical simulation involving collapsible loess.
Quetiapine and Wolff-Parkinson-White Syndrome
Authors: Chen Michael , Gomaa Hassaan , Cortez-Resendiz Alonso , Martin Christopher , Francis Andrew , Bellon Alfredo
Published: December 2020

Quetiapine is occasionally associated with cardiovascular adverse effects such as QTc prolongation. QTc prolongation is a side effect that requires monitoring in order to avoid more serious cardiac complications. One particular understudied area is the potential for antipsychotics to elicit electroconduction abnormalities in patients with Wolff-Parkinson-White (WPW) Syndrome. In the present report, we describe a case of quetiapine overdose in a patient with WPW.
Prognostic Value of Pretreatment Albumin‐to‐Alkaline Phosphatase Ratio in Cancer: A Meta‐Analysis
Authors: Xie Hailun , Wei Lishuang , Tang Shuangyi , Gan Jialiang
Published: December 2020

Background. Recently, it has been reported that the pretreatment albumin‐to‐alkaline phosphatase ratio (AAPR) is related to the prognosis of various cancers. The purpose of this systematic review and meta‐analysis was to explore the prognostic value of pretreatment AAPR on clinical outcomes in cancer. Methods. PubMed, Web of Science, Cochrane Library, and Embase were systematically searched for relevant research before May 2020. Stata 12 was utilized to extract the data and the characteristics of each study and to generate a pooled hazard ratio (HR) and 95% confidence interval (CI) to assess the relationship between pretreatment AAPR and survival outcomes. Results. We included 16 eligible published articles involving 5,716 patients. We found that low pretreatment AAPR was associated with poor overall survival (HR = 2.12, 95% CI: 1.80–2.50, P < 0.001), cancer‐specific survival (HR = 2.89, 95% CI: 1.46–5.71, P < 0.001), disease‐free survival (HR = 1.91, 95% CI: 1.43–2.53, P < 0.001), and progression‐free survival (HR = 1.93, 95% CI: 1.49–2.52, P < 0.001). However, there was no statistical relationship between pretreatment AAPR and recurrence‐free survival, distant‐metastasis‐free survival, or locoregional relapse‐free survival. The correlation between pretreatment AAPR and overall survival did not change significantly when possible confounders were stratified. The sensitivity analysis showed that this study was reliable. Conclusions. Low pretreatment AAPR was significantly associated with adverse clinical outcomes of cancer. Pretreatment AAPR could be a valuable noninvasive prognostic indicator for cancer.
Psychometric Evaluation of the Persian Version of the Childbirth Experience Questionnaire (CEQ)
Authors: Kazemi Samiyeh , Dencker Anna , Pazandeh Farzaneh , Montazeri Ali , Sedigh-Mobarakabadi Sedigheh , Hajian Sepideh
Published: December 2020

Women’s childbirth experience is an outcome indicator for evaluating maternity care. This study evaluated the psychometric properties of the Persian version of the Childbirth Experience Questionnaire (P‐CEQ). The study recruited two hundred and fifty primiparous postpartum women in the 1‐3 months following birth from one private and three public hospitals in Mazandaran province, Iran. First, face validity and content validity were evaluated. Moreover, confirmatory factor analysis (CFA) was conducted, and discriminant validity was assessed by applying the known‐groups method. Intraclass correlation coefficient (ICC) was measured to confirm the stability and Cronbach’s alpha to confirm the internal consistency. CFA also confirmed the values of fit indices (RMSEA = 0.05, SRMSR = 0.06, CFI >0.93, χ2/df = 1.80). ICC was 0.88 and Cronbach’s alpha for all items was 0.85. Furthermore, discriminant validity of the P‐CEQ was approved given that it effectively differentiated women whose stay in the labor unit exceeded twelve hours from those with a shorter stay. The P‐CEQ questionnaire is a valid and reliable tool for assessing childbirth experiences. It is an easy‐to‐use questionnaire that can be used for evaluating quality of care in terms of women’s childbirth experience. It can be used in maternity services that aim to improve quality of care during labor and childbirth.
Stabilization of Two Electricity Generators
Authors: Martinez Dany Ivan , Rubio José de Jesús , Aguilar Arturo , Pacheco Jaime , Gutierrez Guadalupe Juliana , Garcia Victor , Vargas Tomas Miguel , Ochoa Genaro , Cruz David Ricardo , Juarez Cesar Felipe
Published: December 2020

In this research, a sliding mode regulator with sine mapping is suggested for the stabilization of electricity generators being affected by magnet interaction nonlinearities and generator nonlinearities. To reach this goal, our suggested regulator has the following contributions: (a) it starts from the sliding mode regulator with the modifications that the saturation mapping is used to reach a smoother performance instead of the signum mapping, and the sine mapping is applied to reach an upper bound in the proportional gain error, (b) it is used to reach some chosen constant behaviors for the angle position, angle speed, and current in the electricity generators, and (c) its stabilization is ensured based on the Lyapunov approach. We show the simulation of the suggested regulator in two electricity generators.
Adipose-Derived Stem Cells: Current Applications and Future Directions in the Regeneration of Multiple Tissues
Authors: Zhang Jiaxin , Liu Yuzhe , Chen Yutong , Yuan Lei , Liu He , Wang Jincheng , Liu Qiran , Zhang Yan
Published: December 2020

Adipose-derived stem cells (ADSCs) can maintain self-renewal and enhanced multidifferentiation potential through the release of a variety of paracrine factors and extracellular vesicles, allowing them to repair damaged organs and tissues. Consequently, considerable attention has increasingly been paid to their application in tissue engineering and organ regeneration. Here, we provide a comprehensive overview of the current status of ADSC preparation, including harvesting, isolation, and identification. The advances in preclinical and clinical evidence-based ADSC therapy for bone, cartilage, myocardium, liver, and nervous system regeneration as well as skin wound healing are also summarized. Notably, the perspectives, potential challenges, and future directions for ADSC-related researches are discussed. We hope that this review can provide comprehensive and standardized guidelines for the safe and effective application of ADSCs to achieve predictable and desired therapeutic effects.
Stock Index Prices Prediction via Temporal Pattern Attention and Long-Short-Term Memory
Authors: Wei Xiaolu , Lei Binbin , Ouyang Hongbing , Wu Qiufeng
Published: December 2020

This study attempts to predict stock index prices using multivariate time series analysis. The study’s motivation is based on the notion that datasets of stock index prices involve weak periodic patterns, long-term and short-term information, for which traditional approaches and current neural networks such as Autoregressive models and Support Vector Machine (SVM) may fail. This study applied Temporal Pattern Attention and Long-Short-Term Memory (TPA-LSTM) for prediction to overcome the issue. The results show that stock index prices prediction through the TPA-LSTM algorithm could achieve better prediction performance over traditional deep neural networks, such as recurrent neural network (RNN), convolutional neural network (CNN), and long and short-term time series network (LSTNet).
Comparative Five‐Year Surgical Outcomes of Open‐Door versus French‐Door Laminoplasty in Multilevel Cervical Spondylotic Myelopathy
Authors: Chen Guoliang , Liu Xizhe , Zhao Ensi , Chen Ningning , Wei Fuxin , Liu Shaoyu
Published: December 2020

Objective. To compare the five‐year surgical outcomes between Open‐Door laminoplasty (ODL) and French‐Door laminoplasty (FDL) in the management of multilevel cervical spondylotic myelopathy (MCSM). Methods. Sixty patients with MCSM, who were operated by ODL or FDL, were included in this study and followed up for at least 5 years. The average follow‐up period was 69.2 ± 3.2 months. The modified Japanese Orthopaedic Association (mJOA) score and radiological assessments including the Cobb angle and cervical range of motion (ROM) were evaluated and compared before surgery and at the final follow‐up. The incidence of postoperative complications and medical costs were also compared. Results. Both ODL and FDL groups achieved significant improvements of the mJOA score in postoperative 5 years; the average recovery rate (RR) of the mJOA score in the ODL and FDL groups was 72.14 ± 6.97% and 69.53 ± 7.51%, respectively. No statistically significant differences regarding the pre‐ and postoperative mJOA score, the RR of the mJOA score, the loss and the loss rate of the Cobb angle, and the incidence of postoperative complications existed between ODL and FDL. The mean loss and the loss rate of cervical ROM in the FDL group (18.70 ± 8.91°, 41.08 ± 11.17%) were significantly higher than those of the ODL group (13.81 ± 8.62°, 31.47 ± 12.43%) (P < 0.05). FDL reduced medical costs more greatly than ODL (33014.37 ± 3424.12 China Yuan versus 82096.62 ± 7093.07 China Yuan, P < 0.001). Conclusions. Both ODL and FDL are effective for MCSM. The 5‐year neurological results are similar between the two groups. ODL trends to be superior to FDL in postoperative preservation of cervical ROM while FDL reduced medical costs more greatly.
Volatility Similarity and Spillover Effects in G20 Stock Market Comovements: An ICA-Based ARMA-APARCH-M Approach
Authors: Chai Shanglei , Zhang Zhen , Du Mo , Jiang Lei
Published: December 2020

Financial internationalization leads to similar fluctuations and spillover effects in financial markets around the world, resulting in cross-border financial risks. This study examines comovements across G20 international stock markets while considering the volatility similarity and spillover effects. We provide a new approach using an ICA- (independent component analysis-) based ARMA-APARCH-M model to shed light on whether there are spillover effects among G20 stock markets with similar dynamics. Specifically, we first identify which G20 stock markets have similar volatility features using a fuzzy C-means time series clustering method and then investigate the dominant source of volatility spillovers using the ICA-based ARMA-APARCH-M model. The evidence has shown that the ICA method can more accurately capture market comovements with nonnormal distributions of the financial time series data by transforming the multivariate time series into statistically independent components (ICs). Our findings indicate that the G20 stock markets are clustered into three categories according to volatility similarity. There are spillover effects in stock market comovements of each group and the dominant source can be identified. This study has important implications for investors in international financial markets and for policymakers in G20 countries.
Atmospheric Corrosion, Antibacterial Properties, and Toxicity of Silver Nanoparticles Synthesized by Two Different Routes
Authors: DeAlba-Montero I. , Ruiz-Torres Claudio A. , Portales-Pérez Diana P. , Martínez-Gutierrez Fidel , Echeverría Félix , Compeán-Jasso Martha E. , Cataño-Cañizales Yolanda G. , Ruiz Facundo
Published: December 2020

Silver nanoparticles (AgNPs) have been widely employed or incorporated into different materials in biological application, due to their antibacterial properties. Therefore, antimicrobial capacity and cytotoxicity have been highly studied. However, most of these reports do not consider the possible corrosion of the nanomaterials during their exposure to atmospheric conditions since AgNPs undergo a transformation when they come in contact with a particular environment. Derived from this, the functionality and properties of the nanoparticles could decrease noticeably. The most common silver corrosion process occurs by the interaction of AgNPs with sulfur species (H2S) present in the atmospheric air, forming a corrosion layer of silver sulfide around the AgNPs, thus inhibiting the release of the ions responsible for the antimicrobial activity. In this work, AgNPs were synthesized using two different methods: one of them was based on a plant extract (Brickellia cavanillesii), and the other one is the well-known method using sodium borohydride (NaBH4). Chemical stability, corrosion, antibacterial activity, and toxic activity were evaluated for both sets of prepared samples, before and after exposition to atmospheric air for three months. The structural characterization of the samples, in terms of crystallinity, chemical composition, and morphology, evidenced the formation of link structures with nanobridges of Ag2S for non- “green” AgNPs after the air exposition and the intact preservation of silver core for the “green” sample. The antibacterial activity showed a clear improvement in the antimicrobial properties of silver in relation to the “green” functionalization, particle size control, and size reduction, as well as the preservation of the properties after air exposition by the effective “green” protection. The cytotoxicity effect of the different AgNPs against mononuclear cells showed a notable increment in the cell viability by the “green” functionalization.
Huaier Extract Attenuates Acute Kidney Injury to Chronic Kidney Disease Transition by Inhibiting Endoplasmic Reticulum Stress and Apoptosis via miR‐1271 Upregulation
Authors: Zhao Jing-Ying , Wu Yu-Bin
Published: December 2020

Endoplasmic reticulum stress (ERS) is strongly associated with acute kidney injury (AKI) to chronic kidney disease (CKD) transition. Huaier extract (HE) protects against kidney injury; albeit, the underlying mechanism is unknown. We hypothesized that HE reduces kidney injury by inhibiting ERS. In this study, using an AKI‐CKD mouse model of ischemia‐reperfusion injury (IRI), we evaluated the effect of HE on AKI‐CKD transition. We also explored the underlying molecular mechanisms in this animal model and in the HK‐2 human kidney cell line. The results showed that HE treatment improved the renal function, demonstrated by a significant decrease in serum creatinine levels after IRI. HE appreciably reduced the degree of kidney injury and fibrosis and restored the expression of the microRNA miR‐1271 after IRI. Furthermore, HE reduced the expression of ERS markers glucose‐regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) and inhibited apoptosis in the IRI group. This in vivo effect was supported by in vitro results in which HE inhibited apoptosis and decreased the expression of CHOP and GRP78 induced by ERS. We demonstrated that CHOP is a target of miR‐1271. In conclusion, HE reduces kidney injury, probably by inhibiting apoptosis and decreasing the expression of GRP78 and CHOP via miR‐1271 upregulation.
Spectrum and Incidence Trends of AIDS- and Non–AIDS-Defining Cancers between 2010 and 2015 in the French Dat'AIDS Cohort
Authors: Poizot-Martin Isabelle , Lions Caroline , Allavena Clotilde , Huleux Thomas , Bani-Sadr Firouze , Cheret Antoine , Rey David , Duvivier Claudine , Jacomet Christine , Ferry Tristan , Cabie André , Fresard Anne , Pugliese Pascal , Delobel Pierre , Lamaury Isabelle , Chirouze Catherine , Zaegel-Faucher Olivia , Brégigeon Sylvie , Rojas Rojas Teresa , Obry-Roguet Véronique , Makinson Alain
Published: December 2020

Background:

Cancer risk is higher in people living with HIV (PLWH) compared with the general population, and cancers related to age are expected to be most prevalent.

Methods:

We determined the spectrum and incidence rates of AIDS-defining cancers (ADC) and non–AIDS-defining cancers (NADC) and of lung, Hodgkin lymphoma (HL), head and neck (HNC), colon–rectum, anal, liver, breast, prostate, and urinary bladder cancers between January 2010 and December 2015 in the French Dat'AIDS cohort. Incidence rates were calculated by year and compared using the χ2 test for linear trend. Standardized incidence ratios [SIR (95% confidence interval)] were calculated relative to the French general population.

Results:

Among 44,642 patients, corresponding to 180,216.4 person-years (PY), 1,440 cancer cases occurred in 1,314 patients. ADC incidence was 191.4 (172.3–212.7)/105 PY and declined over time overall and in men, whereas NADC incidence was higher [548.8 (515.6–584.1)/105 PY] and did not change. In men, non-Hodgkin lymphoma was the most common cancer, but prostate cancer had the highest incidence among NADCs. Breast cancer was the most common cancer in women. SIRs were higher for cervical cancer [1.93 (1.18–3.14)], HNC in women [2.4 (1.4–4.2)], liver [overall: 3.8 (3.1–4.6); men: 3.2 (2.5–4.0); women: 12.9 (8.3–20.0)], and HL [overall: 13.8 (11.1–17.1); men: 16.2 (12.9–20.4); women: 6.2 (3.22–11.9)] but lower for lung [overall: 0.7 (0.6–0.9); men: 0.7 (0.5–0.8)], prostate [0.6 (0.5–0.7)], and breast cancers [0.6 (0.4–0.7)].

Conclusions:

Spectrum of NADCs has changed, with prostate and breast cancers becoming the most common despite their lower SIR.

Impact:

These results confirm the need to maintain regular epidemiologic cancer monitoring in order to update screening guidelines.
Experiencia de educación sobre la crianza en un asentamiento de Colombia.
Authors: Villa-Vélez Lilliana , Otálvaro-Orrego Jaider Camilo , Peñaranda-Correa Fernando , Bastidas-Acevedo Miryam , Escobar-Paucar Gloria Matilde , Torres-Ospina Julio Nicolás , Betancurth-Loaiza Diana Paola , Gómez-Correa Jaime Arturo
Published: December 2020

Resumen (analítico)Se presenta la experiencia de un proceso educativo orientado a promover transformaciones en las personas y sus condiciones de vida, a partir de una investigación-acción sobre crianza. Durante dos años se realizaron 40 círculos de investigación temática con mujeres desplazadas por la violencia en un asentamiento periférico colombiano, orientados por la educación popular. Con la información registrada en diarios de campo se hizo un análisis hermenéutico. Los temas generadores fueron machismo, violencia, identidad, sexualidad, afecto, autoridad, norma, castigo, oportunidades, sueños, amor, organización social, entre otros. Partiendo de situaciones límite se construyeron códigos narrativos, los cuales permitieron configurar una problematización. La investigación temática permitió realizar una educación en crianza alternativa y constituyó un proceso pedagógico que motivó cambios en la vida de las participantes.
Palabras clave: Educación en salud, cambio social, salud pública, justicia social, crianza del niño.
Show Me the Money
Authors: Dickert Neal W. , Mitchell Andrea R. , Venechuk Grace E. , Matlock Daniel D. , Moore Miranda A. , Morris Alanna A. , Pierce Kenneth J. , Speight Candace D. , Allen Larry A.
Published: December 2020

Background:

Out-of-pocket medication costs for patients who have heart failure with reduced ejection fraction may be an important part of shared decision-making, but cost has generally been excluded from clinical discussions. This study reports patients’ perspectives on a decision aid for sacubitril/valsartan that explicitly addresses out-of-pocket costs.

Methods:

Structured, in-depth interviews were conducted with 20 patients with heart failure with reduced ejection fraction from 2 medical centers to elicit their views on a publicly available decision aid for sacubitril/valsartan that explicitly incorporates considerations related to out-of-pocket costs. Qualitative descriptive analysis was conducted.

Results:

Key themes identified were general enthusiasm for decision aids for medication decisions, openness on the part of patients to incorporation of cost into decision-making and the decision aid, requests for greater specificity regarding patient-specific cost, and challenges communicating evidence of benefit in a way that allows patients to make cost-benefit analyses for themselves. Patients also raised questions regarding logistical challenges of incorporating a decision aid into the normal clinical and decision-making workflow.

Conclusions:

Patients were receptive to the inclusion of out-of-pocket cost as relevant in a decision aid for sacubitril/valsartan. Key challenges to effective integration of cost in these decisions include developing mechanisms for acquiring reliable patient-specific cost estimates and addressing patients’ difficulties (and sometimes skepticism) applying trial evidence to their own situation. In addition, implementation strategies are important to develop to facilitate decision aid integration for routine medical decisions into clinic workflow.
Pharmacodynamic Comparison of Ticagrelor Monotherapy Versus Ticagrelor and Aspirin in Patients After Percutaneous Coronary Intervention: The TEMPLATE (Ticagrelor Monotherapy and Platelet Reactivity) Randomized Controlled Trial
Authors: Johnson Thomas W. , Baos Sarah , Collett Laura , Hutchinson James L. , Nkau Martin , Molina Maria , Aungraheeta Riyaad , Reilly‐Stitt Christopher , Bowles Ruth , Reeves Barnaby C. , Rogers Chris A. , Mundell Stuart J , Baumbach Andreas , Mumford Andrew D.
Published: December 2020

Background

To assess differences in platelet inhibition during ticagrelor monotherapy (TIC) or dual therapy with ticagrelor and aspirin (TIC+ASP) in patients after percutaneous coronary intervention using a comprehensive panel of functional tests.

Methods and Results

In a single‐center parallel group, open label, randomized controlled trial, 110 participants were randomized to receive either TIC (n=55) or TIC+ASP (n=55) for 4 weeks. The primary outcome was the platelet aggregation response with 10 μmol/L thrombin receptor activation peptide‐6 (TRAP‐6). The secondary outcomes were platelet aggregation responses and binding of surface activation markers with a panel of other activators. The mean percentage aggregation for 10 μmol/L TRAP‐6 was similar for the TIC and TIC+ASP groups (mean difference+4.29; 95% CI, −0.87 to +9.46). Aggregation was higher in the TIC group compared with the TIC+ASP group with 1 μg/mL (+6.47; +2.04 to +10.90) and 0.5 μg/mL (+14.00; +7.63 to +20.39) collagen related peptide. Aggregation responses with 5 μmol/L TRAP‐6, 5 μmol/L or 2.5 μmol/L thromboxane A
2
receptor agonist and surface activation marker binding with 5 μmol/L TRAP‐6 or 0.5 μg/mL collagen related peptide were the same between the treatment groups.

Conclusions

Patients with PCI show similar levels of inhibition of most platelet activation pathways with TIC compared with dual therapy with TIC + ASP. However, the greater aggregation response with collagen related peptide during TIC indicates incomplete inhibition of glycoprotein VI (collagen) receptor‐mediated platelet activation. This difference in pharmacodynamic response to anti‐platelet medication may contribute to the lower bleeding rates observed with TIC compared with dual antiplatelet therapy in recent clinical trials.

Registration Information

URL:
https://www.isrctn.com
; Unique Identifier ISRCTN84335288.
An Emerging Social Ethics
Authors: Medina Néstor
Published: December 2020

This article proposes that a new pentecostal social ethic is emerging in the region. Examining recent developments of Pentecostalism in Latin America along with Latin American scholars, I will discuss, in thematic form, some of the recent developments affecting pentecostal movements in the region from revising its historical origins, celebrating its internal diversity, reconsidering political involvement, reclaiming the crucial role of women’s contributions, to developing a social ethics seeking to respond in relevant ways to the social issues confronted by the Latin American population. Though the influence of liberation theology is noticeable, these groups are drawing on the pentecostal experience to reinterpret their relationship with the larger social context and internally. Particular attention is given to the great internal diversity within pentecostal movements in Latin America
Signs of Contradiction: Understanding the Church, the Papacy, and the World around Us through a Textual Analysis of HBO’s The Young Pope
Authors: Kennedy Mary Catherine
Published: December 2020

This paper examines hbo’s The Young Pope through a cultural approach and ritual view to communication first developed by James W. Carey (2009). After a discussion of mediatization of society and its impacts on culture, the essay explores the deeper meanings The Young Pope conveys about self-discovery and the power of love through a textual analysis of the mythic structure of the hero’s journey (Campbell, 1949/2008; Kluckhohn, 1959) in order to understand how religious belief systems and media content paired together can offer a particular view of the world to those who ascribe to them. Ultimately, this paper serves as a piece of media criticism that suggests that television series like The Young Pope can operate as “sites of interpretive struggle” (Peterson, 2008, p. 119) for viewers as they draw conclusions about and question the world around them.
Polish Catholic Magazines and Bioethical Dilemmas: A Critical Discourse Analysis
Authors: Przybysz-Polakowska Kinga
Published: December 2020

This article presents a cad-based analysis of Polish Catholic newspaper discourse regarding bioethical dilemmas. The study corpus consists of materials published by four weekly magazines – Gość Niedzielny, Niedziela, Przewodnik Katolicki, and Tygodnik Powszechny – between 2005 and 2015. The author took into consideration articles that were fully devoted to abortion, in vitro fertilization, or euthanasia. The research methodology was based on critical discourse analysis and delivered both quantitative and qualitative results. The findings suggest that even though all magazines touched on bioethical dilemmas and conjured up similar topics, their discourses were different. It transpired that the key variable was the magazines’ affiliations. Titles directly connected to the Catholic Church (Gość Niedzielny, Niedziela, Przewodnik katolicki) produced different discourses than Tygodnik Powszechny, which has no official bonds with the Catholic Church. Given the structure of the discourses, the author suggests division into two categories: inward-oriented and outward-oriented.
Defining Ottoman Realism in the Uppsala Mecca Painting
Authors: Beyazıt Deniz
Published: December 2020

This article analyzes a little-known painting of the sanctuary at Mecca in the Uppsala University Library, Sweden—one of the most sophisticated depictions of its kind. Datable to ca. 1700 and attributable to Cairo, the painting is among the earliest known depictions of the Holy Places in an illusionistic style with a bird’s-eye view, composed according to linear perspective. With minutely rendered details accompanied by more than seventy inscriptions, the work functions as an early map of Mecca. The Uppsala Mecca painting exemplifies the complexity of artistic exchange between Europe and the Ottoman world, which yielded highly original results. This discussion sheds light on the long, hybrid journey of Ottoman art towards realism, applied to a large-scale topographic landscape composition. The work marks a turning point in the history of Mecca painting and served as a model for European prints, through which the imagery spread all the way to East Asia. This study attempts to unravel the mysterious origins of the painting in the context of seventeenth- and eighteenth-century Egypt and the power struggles to control Egypt, the Hijaz, and the Hajj.
Calouste Gulbenkian, His Mīnāʾī Ware, and the Changing Islamic Art Market in the Early Twentieth Century
Authors: Piran McClary Richard
Published: December 2020

This article aims to provide a clearer understanding of the emerging market for Islamic art in the early decades of the twentieth century through a study of the changing purchasing habits of one European collector, Calouste Gulbenkian, and specifically his acquisition of mīnāʾī ware. Such an approach allows for a coherent, focused study that engages with the leading dealers, agents, and auction houses of the time. These were located primarily in Paris and, to lesser extent, New York and London, in the key period during which the Islamic art market became a major part of the broader art and antiquities business. The main focus is on the shift from buying newly excavated fragmentary material from Armenian dealers to purchasing seemingly complete, but heavily restored, bowls from established collections sold at the leading auction houses. Each of the pieces in Gulbenkian’s collection of mīnāʾī ware is examined in detail, and a new taxonomic classification is presented for this well known, but still poorly understood, class of Islamic ceramics.
Rembrandt, Lievens, Dou
Authors: Perry Chapman H.
Published: December 2020

Taking license from Just Kids, Patti Smith’s 2010 memoir of her youthful, intense working friendship with photographer Robert Mapplethorpe, this essay examines Rembrandt’s artistic friendships with his colleague Jan Lievens, and his first pupil, Gerrit Dou. The burst of competitive, extreme co-creativity of Rembrandt and Lievens during their Leiden years comes to a head in their rendering of the raising of Lazarus; its strains are evident in Rembrandt’s Oriental heads. The life-long, seemingly more sustained friendship of Rembrandt and Dou is encapsulated in Dog at rest, Dou’s homage to his master as exemplary teacher. These two working relationships point not only to the power of artists serving as each other’s muses, but also to the need for further investigation into the value, and exploitation, of friendships for Rembrandt.
Aux origines de la « frankokratia »
Authors: Grivaud Gilles , Nicolaou-Konnari Angel
Published: December 2020

La Grande Idée et la guerre de Crimée façonnent le cadre idéologique et politique dans lequel se déroule une prise de conscience de la période spécifique que constitue la « φραγκοκρατία ». En multipliant les parallèles entre les événements des années 1850 et ceux du XIIIe siècle, on entend démontrer que l’Occident ne comprend rien au monde grec, qui, en conséquence, doit le rejeter. Byzance obtient ainsi sa complète réhabilitation, entraînant par ricochet une virulente critique contre les « Francs », coupables de son renversement. Cette appréhension des rapports de force est amplifiée par Constantin Paparrigopoulos qui construit le roman national grec en proposant sa conception de l’hellénisme trimillénaire. Progressivement, l’hostilité à la « φραγκοκρατία » se diffuse, et devient un segment original de l’histoire médiévale grecque sous l’impulsion de Spyridon Lambros, au début du XXe siècle. (La première partie de l’étude figure dans Frankokratia 1 (2020), 3‑55.)
The Effects of Extracts from "Red Complex" Pathogens on Human Dental Follicle Cells
Authors: Huang Yueyue , Wu Shuang , Zhou Yi , Zhou Yue , Xu Xiaomei , Zuo Dongchuan , Yuan Xiaoping , Zeng Jin
Published: December 2020

Dental follicle cells could be a natural source of cells for regeneration therapies in periodontitis. The "red complex", which include Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, is strongly associated with periodontitis. However, the
effects of "red complex" on dental follicle cells remains largely unknown. In this study, we evaluated the effects of bacterial extracts obtained from Porphyromonas gingivalis and from "red complex" (Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia in co-culture)
on proliferation, migration and osteogenic differentiation of human dental follicle cells. Our data showed that bacterial extracts promoted cell proliferation and migration, decreased the alkaline phosphatase activity, osteogenic genes expression and formation of mineral deposits. Noticeably,
compared with the inhibitory effects induced by bacterial extracts from Porphyromonas gingivalis on osteogenic differentiation of human dental follicle cells, the inhibitory effects induced by bacterial extracts from "red complex" were more significant. In conclusion, the extracts from
"red complex" pathogens inhibited osteogenic differentiation capacity of human dental follicle cells, and this provides a theoretical basis for the clinical application of stem cell therapy in periodontal tissue engineering.
Effects of miR-128 on the Proliferation and Apoptosis of Lung Cancer of Non-Small Cell by Regulating Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK)
Authors: Shan Li-Qun , Yan Hong-Wang , Lin Hui , Yu Hong-Xi , Zhang Bo , Li Ming-Dong , Zhang Shuai
Published: December 2020

The study was aimed to analyse the effects of miR-128 on the proliferation and apoptosis of lung cancer cells of non-small cell by regulating RECK. The expression of miR-128 in non-small cell lung cancer (NSCLC) and its paracancerours tissues was analyzed by sequencing. miR-128 expression
level in NSCLC and its paracancerours tissues was detected by qPCR. We over expressed miR-128 by mimics in A549 NSCLC cell line. Establish blank and negative control group. miR-128 and RECK expression level in each group was detected by qPCR. Use MTT assay to test the proliferation ability
of each group. The apoptosis level and the level of ROS in each group were tested by hoechst 33258. The expression level of apoptosis-related protein and p38 NF- B signal pathway-related protein in each group was tested by Western blot. The results of sequencing and qPCR showed that compared
with the blank control group, the expression level of miR-128 mRNA was significantly higher in the adjacent tissues than in the adjacent tissues (P < 0 05). The expression levels of miR128 mRNA and RECK mRNA in the overexpression group were significantly increased (P <0 05); the cell
proliferation ability in the overexpression group was significantly reduced (P < 0 05), and the level of apoptosis was significantly increased (P < 0 05). Overexpression group Caspase-3, Bcl2/Bax, P-p38, NF-B expression levels were significantly increased (P < 0 05). MiR-128 increases
ROS level in NSCLC cells, inhibits cell proliferation and promotes cell apoptosis by regulating RECK and acting on p38 NF-κB signaling pathway.
Troxerutin Attenuates TGF-β-Induced Fibrosis of Renal Tubular in HK-2 Cells by Activating MG-53
Authors: Zhu Jun , Wang Gang
Published: December 2020

This study aimed to investigate the effect of Troxerutin on TGF-β-induced fibrosis of renal tubular cells and whether it can participate in the activation of MG-53. After induction of HK-2 cells with TGF-β 100 ng/ml for 24, 48 and 72 hours, the level of inter cellularization
was detected by western blot. After treatment with different concentrations of Troxerutin, The expression of E-cad, N-cad, -SMA, collgen-I and FN were detected by western blot, and the expression of N-cad and -SMA were detected by immunofluorescence. Furthermore, the interference plasmid of
MG-53 was transfected into HK-2 cells. The expression of MG-53, E-cad, N-cad, α-SMA, collgen-I and FN expression were detected by western blot. TGF-β-treated HK-2 cells increased inter cellularization and fibrosis, and Troxerutin attenuated TGF-β-induced cell cytoplasmic and
fibrotic protein production. TGFinhibits the expression of MG-53, while Troxerutin increases the expression of MG-53, and reduces TGF-β-induced interstitial and renal fibrosis by increasing MG-53. These results suggested that troxerutin attenuates TGF- β-induced renal cellular fibrosis
in HK-2 cells by activating MG-53. This study provided novel insights into the mechanisms of troxerutin in the protection of the renal.
miR-194 Inhibits Ovarian Cancer Cell Proliferation and Reduces Cisplatin Resistance by Targeting Yes-Associated Protein
Authors: Tang Hao , Gong Ping , Tao Ling , Hua Yurong
Published: December 2020

Elevated expression of Yes-associated protein (YAP1) is associated with ovarian cancer. Bioinformatics analysis showed a relationship between miR-194 and YAP1. Our study intends to assess whether miR-194 regulates YAP1 expression and affects the proliferation of ovarian cancer cells
and CDDP resistance. CDDP-resistant cell line A2780/CDDP was established and the expression of miR-194 and YAP1 in parental A2780 cells and normal ovarian epithelial IOSE80 cells were compared. A2780/CDDP cells were separated into miR-NC group and miR-194 mimic group followed by analysis of
miR-194 and YAP1 expression, and cell apoptosis and proliferation by flow cytometry. There was a targeted relationship between miR-194 and YAP1 mRNA. A2780/CDDP cells had the lowest miR-194 expression followed by A2780 cells and IOSE80 cells. In addition, YAP1 level was highest in A2780/CDDP
cells followed by A2780 cells and IOSE80 cells. Compared with miR-NC group, miR-194 expression was significantly increased in miR-194 mimic transfection group and YAP1 protein expression was significantly decreased, with increased cell apoptosis and reduced cell proliferation ability. Decreased
miR-194 expression and increased YAP1 expression are related to ovarian cancer CDDP resistance. Increased miR-194 can down-regulate YAP1, inhibit ovarian cancer cell proliferation, promote cell apoptosis, and reduce CDDP resistance.