bluuebunny/crossref_metadata_2025 huggingface dataset:
AN AUTOPSY CASE OF VISCERAL HERPES SIMPLEX
Authors: Nakata Katsuji , Nakai Masuyo , Hamawaki Hiroki
Published: December 2008

Autopsy findings of visceral herpes simplex in a newborn infant and electronmicroscopic findings of both the liver cell and herpes simplex' virus are described. Severe hemorrhagic necrosis with intranuclear inclusion bodies and giant cell formation of liver cell, known to be characteristic to visceral herpes simplex, was found. Various developing stages of herpes simplex virus were observed in the liver cells by means of electronmicroscopy. Two types of intranuclear inclusion bodies were distinguished. One was a granular inclusion body which composed of various numbers of virus particles, and the other, Cowdry type A inclusion which did or did not contain virus particles. It was also shown that intranuclear aggregates, presumably of nonspecific protein, were responsible for the granular appearance of the inclusion body, and that the Cowdry type A inclusion body was formed by fusion of these aggregates. Several evidences suggested placental infection in the present case.
AN AUTOPSY CASE OF ACHONDROPLASIA IN ONE OF BINOVULAR TWINS OF DIFFERENT SEX
Authors: Morii Sotokichi , Takada Reiko , Kaneko Tadashi , Kaida Koichi
Published: December 2008

An achondroplastic female newborn in one of binovular twins of different sexw as reported. The incidences of this peculiar dwarfism were also reported, which were based on the delivery records in our clinic for the recent 5 years and on the statistics of over 90,000 autopsy cases in Japan from 1958 to 1964.

Neither apparent hereditary factor nor contributory clinical history of their parents was detected. The autopsy of the twins revealed that the female infant was a typical achondroplastic dwarf associated with pulmonary hypoplasia and hypoplasia of the endocrine organs, and that the male infant was a nonachondroplastic premature baby of 8 months gestation, who died of respiratory distress due to hyaline‐like membrane.

Histochemical findings of the ground substance of the cartilages, fixed by different fixatives, of both cases were compared. After formalin fixation, in the abnormal cartilages of the achondroplastic acid mucopolysaccharide diminished distinctly. After ethanol fixation, however, much of the acid mucopolysaccharide was retained. The histochemical tests suggested that the intense reactions in the ethanol‐fixed materials would be due to the presence of chondroitin sulphuric acid A or C. Therefore, chondroitin sulphuric acid in the achondroplastic cartilage might not be bound with protein of the ground substance.
ENDOMETRIOSIS OF THE PELVIC LYMPH NODES
Authors: Aoki Mikio
Published: December 2008

Pelvic lymph nodes removed by operation of 1284 cases of various gynecological carcinomas as well as 166 cases of rectum carcinoma of females were examined. Glandular inclusions were found in 30 cases, i.e. 27 cases of carcinoma of the uterine cervix, a case of ovarian carcinoma, a case of malignant melanoma of the vagina and a case of rectum carcinoma. On the basis of their morphology, localization in the lymph nodes and mode of distribution in the pelvis, it was concluded that these glandular inclusions were endometriosis, namely endometrial glands transported from the uterine body through lymphatic channels. The incidence was 2.296 in the presence of carcinoma of the uterine cervix. The incidence seemed to be far lower in Japan than in western countries.
ELECTRON MICROSCOPIC OBSERVATION OF THE HUMAN THYMUS OF THE FETUS AND THE NEWBORN
Authors: Hirokawa Katsuiku
Published: December 2008

The human fetal thymus has been systematically studied by electron microscopy. The basic structure of the thymic parenchyma is a spongy meshwork, loose in cortex and dense in medulla, composed of two types of epithelial reticulum cell. The meshworks are packed predominantly with thymocytes of variable stages of maturation and partly with macrophages. type, found only in the medulla, is hypertrophic and has characteristic The first type of epithelial reticulum cells is slender and electron opaque, forming supporting element of meshwork(the slender type). The second type, found only in the medulla, is hypertrophic and has characteristic vesicles of two sorts (the hypertrophic type), the large one of which is provided with microvillous projections and contains fine granular substance of moderate electron density which corresponds to the PAS positive granule of METCALF1. SO it might be suggested that the hypertrophic ones have an endocrine activity. The HassaU's corpuscle is composed of cellular aggregation of the hypertrophic type. The function of the thymus in the human fetus is discussed laying stress on the epithelial reticulum cell.
AN AUTOPSY CASE OF PRIMARY OSTEOMYELOSCLEROSIS IN A 6‐YEAR‐OLD GIRL
Authors: Nagai Kazunori , Sugiyama Yoshihiko , Isono Yuya , Yoshida Kosaku
Published: December 2008

A case of a 6‐year‐old girl with primary osteomyelosclerosis was reported. Clinically she had general fatigue, anemia and hepato‐splenomegaly. The peripheral blood showed anemia with leuco‐erythroblastic picture, anisocytosis and tear‐drop poikilocytosis of the red cells, and marked thrombocytosis. Diagnosis of osteomyelosclerosis was established by biopsies of the liver and bone marrow which showed dry tap aspiration. The patient died 1 year and 2 months after the onset of symptoms.

Autospy findings revealed marked flbrillosis, proliferation of all 3 hematopoietic systems and moderate new formation of bone in the bone marrow. Extramedullary hematopoiesis associated with flbrillosis was found in the liver, spleen, lymph nodes, thymus, adrenal glands, lungs and kidneys. There were multiple thrombi in the inferior vena cava, left renal vein, pulmonary vessels, both suprarenal arteries with infarcts in the adrenal glands. It is considered that osteomyelosclerosis is not a reactive or reparative process in nature but a systemic autonomous progressive blood disease. A possible relationship between abnormality of the thymus and primary osteomyelosclerosis was suggested.
IMMUNO‐CYTOCHEMICAL STUDY ON THE DEVELOPMENT AND DIFFERENTIATION OF THE IMMUNE SYSTEM OF THE HUMAN FETUS
Authors: Hirokawa Katsuiku , Hatakeyama Shigeru
Published: December 2008

The lymphatic tissues of human fetus and infant were studied systematically from an immuno‐cytochemical view‐point. Among immunoglobulins, γA and γM first appeared in the primitive mesenchymal cells around the mesenteric and hepatic hilar vessels at the 11th fetal week. These cells were considered to be the primordium of the gut wall lymphoid tissues; the thymus and the bursa type tissue. γM in the reticular cells and γA in the medium‐sized lymphoid cells were identified in the thymus after the middle of fetal life. γG, maternal in origin, was observed in the eosinophilic cells, mostly in the thymus. After passing middle fetal life, these three types of immunoglobulins were found in the HassaU's corpuscles, increasing quantitatively toward the end of fetal life. The role of thymus in the development of the immune system during the human fetal life was discussed in relation to other lymphatic tissues.
THE ROLE OF ENDOTHELIAL CELLS IN THE PATHOGENESIS OF ATHEROSCLEROSIS
Authors: Iwanaga Yasuto , Tanimura Akira , Kitsukawa Hirohide , Tanigawa Junji , Aihara Manabu , Kawashima Taketsugu , Mae Atsuo , Nakashima Teruyuki
Published: December 2008

Using mainly rabbits and rats investigations on the endothelial permeability of the aorta, on relation between thrombus formation and endothelial damage, and on tissue culture of the endothelial cells of the rabbit aorta have been carried out.

The permeability of endothelial layer of rabbit aorta Increased by cholesterol‐feeding. This seems to be derived from morphological and functional disorder of the endothelial cells. As a hemodynamic effect of blood flow, increased permeability of the endothelium of rat aorta was also found in experimental renal hypertension.

Accumulation of blood‐plasma components (edema) was seen in the subendothellal area in cholesterol‐fed rabbit aorta and in hypertensive rat aorta. Long‐standing subendothellal edema is considered to be the cause of fibrous intlmal thickening (Grade I lesion/Nakashlma).

Endothelial defect of the aorta due to various damages is related to thrombus formation, and this seems to be accelerated by cholesterol feeding.

Morphological differences between normal endothelium and that of atherosclerotic lesion in human and in rabbit aortas can be seen.

Tissue culture of the endothelium was performed in vivo and in vitro, and some discussions were made on the characteristics of cultured endothelial cells.
HISTOLOGICAL STUDY OF MUSCULAR CHANGES IN PROGRESSIVE MUSCULAR DYSTROPHY
Authors: Hizawa Kazuo , Nagamine Nobuo , Yoshimura Satohisa , Katsuse Retsu , Kishino Yasuo
Published: December 2008

Changes of skeletal muscle of 28 patients with progressive muscular dystrophy were studied light microscopically. Slowly progressive muscular atrophy with various forms of degeneration and more acute necrosis with incomplete regeneration were the principal changes. Fatty tissue infiltration and fibrosis of the interstitial tissue seemed to occur relatively late in the course of the disease. Incidence of necrosis and regeneration of muscle fibers are significantly higher in the Duchenne‐type dystrophy and in an early stage, thus giving some quantitative difference concerning the genetic clinical types and duration of the disease, though no definite specific change is found for each type of muscular dystrophy.

Significance of these changes are discussed from a morphological standpoint and under consideration of biological speciality of muscle fiber. Regenerative substitution of necrotic muscle fiber performed by survived nuclei of the necrotic fiber itself in close association of myophago‐cytosis appeared to be a peculiar process exhibited by skeletal muscle as a syncytial cell.
AN AUTOPSY CASE OF ATAXIA‐TELANGIECTASIA
Authors: Itatsu Yoshiaki , Uno Yutaka
Published: December 2008

A case of a 10‐year‐old girl with ataxia‐telangiectasia was described. While the cause of this disease is still unknown, possible etiologies and relevant clinical implications were briefly discussed.
TWO AUTOPSY CASES OF RENAL HYPERTENSION WITH HYDRONEPHROTIC PYELONEPHRITIS DUE TO FIBROUS RETROPERITONITIS
Authors: Tanaka Ryozo , Tashiro Takao , Kitamura Shiro
Published: December 2008

Two autopsy cases of renal hypertension with hydronephrotic pyelonephritis due to fibrous retroperitonitis are reported.

The first case suffered from continuous hypertension, inspite of nephrectomy of the left kidney which was conspicuously atrophic and showed marked hydroureter due to proliferative endoarteritis of the left renal artery and retroperitoneal fibrosis. On autopsy, there was compensatory hypertrophy of the right kidney with partial cicatrical contraction due to obstructive endoarteritis of the lower branch of the right renal artery. The retroperitoneal fibrosis extended from the pericystic area to the upper abdomen.

The second case had two remarkable changes, one of which was atrophy of the right kidney due to proliferative endoarteritis of the stem of the right renal artery and another was bilateral hydronephrotic pyelonephritis owing to retroperitoneal fibrosis.

Moreover, systemic proliferative vasculitis were found in both cases.

The relationship of these lesions was discussed.
AN AUTOPSY CASE OF KLIPPEL‐TRÈNAUNAY‐WEBER'S DISEASE
Authors: Inui Michio , Chiba Rikio , Shike Shótichiro
Published: December 2008

A case of a 13‐year‐old boy who suffered from unilateral hypertrophy of extremities, chest wall and shoulder, and diagnosed as Klippel‐Trenaunay‐Weber's disease, was reported. The patient terminated in sudden death following rupture of intrasplenic aneurysm. Review of the literature and the entity of this disease were discussed.
A HISTOPATHOLOGICAL STUDY ON THE EFFECT OF VARIOUS DRUGS IN EXPERIMENTAL MURINE LEPROSY
Authors: Sasaki Norisuke
Published: December 2008

The effect of a high molecular unsaturated fatty acid C22H36O2 (RTB) In the treatment of experimental murine leprosy was studied for a one‐year long term in parallel with Isonicotinic acid hydrazide (INAH), its derivatives Isonicotinoyl 3–4‐diethoxy benzol hydrazone (No. 284), and a salivary gland hormone (Parotin). The effectiveness of RTB on experimental murileproma was found to be weaker than INAH and No. 284, but almost the same as Parotin. The healing mechanism of RTB and Parotin is not a direct bacteriocidal action, but has a phagocytic and bacteriolytic mechanism of histiocytes due to activation of the reticuloendothelial system. The characteristic findings following RTB administration were predominant proliferation of “argyrophilic fiber type of histiocytes” and argyrophilic fibers, and the new formation of blood‐capillaries. At the same time, the healing process of various drugs and the non‐inhibitory effect of RTB were histopathologically discussed.
PRIMARY EMBRYONAL CARCINOMA OF THE ANTERIOR MEDIASTINUM
Authors: Hirokawa Katsuiku
Published: December 2008

An autopsy case of embryonal carcinoma in the anterior mediastinum developing in a 49‐year‐old male is reported. The tumor showed a great variety of histological patterns, all of which can be regarded as tumor of germ cell origin. Wide‐spread hematogenous metastasis was found especially in the right lung. Specific histological features of Teilum's endodermal sinus tumors may enable their proper identification from thymoma or other types of neoplasm in the mediastinum.

The histogenesis of extragonadal germ cell tumors was also discussed. ACTA PATH. JAP. 19: 409˜418, 1969.
SELECTIVE INJURY OF MITOCHONDRIA WITH JANUS GREEN B AND RUBY LASER LIGHT —ENZYME MORPHOLOGICAL AND ULTRASTRUCTURAL STUDY*—
Authors: Baba Kensuke
Published: December 2008

Whole HeLa cells supravitally stained with Janus green B were irradiated with ruby laser light, in order to injure mitochondria selectively. For light microscopic observation, NADH dehydrogenase activity was used as a marker for mitochondria. Immediately after irradiation, the cells stained for NADH dehydrogenase activity showed small vacuoles outlined with the enzyme reaction product and punched‐out lesion in cytoplasm, distribution of which corresponded to that of mitochondria in control cells. Electron microscopic observation of irradiated cells disclosed electron opaque particles in mitochondrial matrix and varying sized vacuoles in mitochondria. The light and electron microscopic changes were confined within the mitochondria at the optimum conditions of the dye concentration and the laser light intensity. On morphological bases, it was concluded that mitochondria were selectively injured by the combination of Janus green B supravital stain and ruby laser light irradiation.
AN AUTOPSY CASE OF COLLISION TUMOR
Authors: Indo Katsuhiko , Aotani Takashi
Published: December 2008

At autopsy of a 60‐year‐old male, the authors found two malignant tumors occurring in different organs. One was hepatocellular carcinoma originating in the right lobe of the liver, and the other was leiomyosarcoma occurring in the right retroperitoneal space. They collided at the edge of the right lobe of liver and mixed together. The mixed area showed structures of true carcinosarcoma.
INCREASE OF COLONY FORMING CELLS IN PERIPHERAL BLOOD BY HISTAMINE INJECTION
Authors: SEKI Masatoshi
Published: December 2008

For the purpose to study the humoral control of defensive responses, kinetics of colony forming cells (GFC) In peripheral blood of histamine ‐injected mice was assayed by modification of McCulloch and Till's method, with usual hematological examinations. Effects of histamine on adrenalectomized mice and hydrocortisone injection into intact animals were also examined in the same manner. In conventional mice, histamine caused marked leukopenia and a rise of hematocrit value by 15 minutes after the injection, the latter of which was restored within 30 minutes. On the other hand, high hematocrit value continued for more than 1 hour in adrenalectomized mice.

Histamine administration into conventional mice caused a temporary increase of peripheral CFC by 1–3 hours after the injection, accompanied by granulocytosis. Afterwards, CFG count reverted to control level. In adrenalectomized mice, count of peripheral CFG was about two times of that of control. Histamine administration into adrenalectomized mice caused remarkable increase of peripheral CFC by 3 hours after the injection. On the contrary, hydrocortisone decreased peripheral CFC count distinctly. ACTA PATH. JAP. 20: 141 ‐ 152, 1970.
ÜBER DIE IDIOPATHISCHE KARDIOMYOPATHIE – PATHOLOGISCHE UNTERSUCHUNG VON 16 FÄLLEN –
Authors: IMAI Miki , TAKEISHI Makoto , HIEAYAMA Akira , TOYODA Chisato , KOYAMA Kazuko , MITKAI Miwako , ASAHI Mitsuhisa
Published: December 2008

The present study consists of 16 cases of idiopathic cardiomyopathy ranging between 7 to 68 years of age. All cases demonstrated moderate degree of dilatatory hypertrophy of both ventricles with some having mural thrombosis. Over‐all distribution of scar and degeneration of heart muscle cells was considered to be the characteristic features of idiopathic cardiomyopathy. A variety of transitional changes between myocardial degeneration and collagenous scars were found in the younger age group, and fall‐off of myocardium was interpreted to result in scar formation. Hypertrophy of heart muscle cells is a compensatory phenomenon following partial fall‐off of muscle cells. Vacuolar changes, deposition of waxlike substance and bizarre nuclei found in the hypertrophic muscle cells are in general not characteristic for this condition.

One must be careful in differentiating idiopathic cardiomyopathy and mitral insufficiency having multiple scars and of rheumatic nature from both clinical and pathologic standpoints.

Endocardial fibroelastosis should not be included in the entity of idiopathic cardiomyopathy, since the role played by the myocardium in the pathologic process is much less in endocardial fibroelastosis. ACTA PATH. JAP. 20: 153–169, 1970.
AN AUTOPSY CASE OF SCHMIDT'S SYNDROME
Authors: UEI Yoshio , TAKAHASHI Yohei
Published: December 2008

A 49‐year‐old Japanese woman, who developed adrenal and thyroid insufficiency approximately 8 years prior to death and expired from adrenal insufficiency was described. No specific endocrinological and immunological tests were performed. Autopsy revealed idiopathic Addison's disease, Hashimoto's thyroiditis, acute glomerulonephritis and primary hyperplasia of parathyroid gland. Reviewing the literature some comments were made on the incidence, morphology and pathogenesis of idiopathic Addison's disease and Schmidt's syndrome. This is the first case of Schmidt's syndrome as well as of idiopathic Addison's disease in Japan. ACTA PATH. JAP. 20: 215 ‐ 226, 1970.
AN AUTOPSY CASE OF DIPROSOPUS
Authors: KUDO Hajime , TODA Seiichi
Published: December 2008

A case of diprosopus, a very rare malformation belonging to dupli‐citas, of a female newborn is reported. This diprosopus monauchenos tetrophthalmus triotus dioris was delivered from a 33 years old multipara. Autopsy revealed duplication of cerebral hemispheres, 1st, 2nd and 3rd cranial nerves, hypophysis, intracranial internal carotid arteries, basilar artery and tip of tongue. This diprosopus had also congenital cardiac and great vessel anomalies consisting of double outlet right ventricle without pulmonary stenosis, coarctation of aorta (infantile type), ventricular septal defect, patent ductus arteriosus, patent foramen ovale and thick right ventricular wall. Except for mesenterium commune, the organs in the chest and abdomen, and the extremities were normal in position, shape and number. ACTA PATH. JAP. 20: 239–249, 1970.
TWO AUTOPSY CASES OF REYE'S SYNDROME
Authors: MOTOI Makoto , KOBAYASHI Shoji , OGAWA Katsuo , MURAKAMI Motomasa , AOYAMA Koji , YODA Tadao
Published: December 2008

Autopsies were carried out on a ten‐month old male and another 7‐year‐old boy who died within a few days after showing slight upper respiratory infection as a prodromal symptom, followed by vomiting, disturbances of consciousness and high fever. Both of these cases showed high transaminase levels, accompanied by low blood sugar, and patho‐anatomically, they had marked fatty degeneration of the liver and kidneys, and remarkable edema of the brain. The lung showed a slight inflammation of the interstitiums. Only mild inflammation was found in the intestines.

These clinical and pathological findings coincide with the conception of Reye's syndrome, and some discussions have been made about the differentiation between Reye's syndrome and those closely resembling this syndrome. ACTA PATH. JAP. 20: 251–259, 1970.
IMMUNOLOGICAL AND HISTOLOGICAL STUDIES OF THE PROLONGED ADMINISTRATION OF γG FRACTION OF ANTILYMPHOCYTE SERUM
Authors: Ochiai Takenori
Published: December 2008

Rabbits were treated with the prolonged administration of γG fraction of goat anti‐rabbit lymphocyte serum (ALγG) over 180 days. The effect of ALγG on various kinds of immune responses was examined at different stages of the experiment.

The antibody against ALγG appeared at an early stage. Especially the formation of γM antibody was rather enhanced as compared to the control animals which received normal goat γG (NγG). The antibody titer increased, and then maintained its level through the course of experiment. However, a slight decline of the titer was noted in the last stage. The Immune responses against sheep red blood cells, bovine serum albumin and skin homograft were greatly suppressed by the short‐term treatment of ALγG. On the other hand, no suppression of the immune responses was demonstrated in the group treated with ALγG for 180 days as compared with the control group.

The results indicate that ALγG used is effective to suppress the immune responses in the short‐term treatment, but it is probably neutralized by the antibody and causes no further immunosuppression. In addition, it has also been confirmed that an exhaustion of the lymphoid tissues accompanying occasional amyloidosis might be induced by the long‐term administration of ALγG.
STUDIES ON TUBERCULIN GRANULOMA EXPERIMENTALLY PRODUCED ON THE GUINEA PIG MESENTERY
Authors: Yamaguchi Hisao , Fukuda Junya , Kageyama Keizo
Published: December 2008

Tuberculin reaction in guinea pig mesentery has been studied as a model of delayed type hypersensitivity. The results obtained through these series of experiments are; 1) even in the delayed type hypersensitivity, the initial phase of the reaction consists of microclrculatory disturbances similar to those of the immediate type reaction, and 2) the capacity of lymphatic drainage after plasma exudation is the essential factor for the formation and absorption of granulomas which are located in rather far distant areas from the vascular tree.
MORPHOLOGY OF EXPERIMENTAL CHORIONIC TUMORS IN RATS
Authors: Miyamoto Makoto , Nilsuwarn Naiyana , Angsubhakorn Subhkij
Published: December 2008

Four additional chorionic tumors have been obtained by the same method as previously reported1 using 4‐NQO and 7,12‐DMBA as carcinogens. It was observed that high dosage of DMBA was quite effective in inducing chorionic tumors in rats. Gross and histological appearance of the tumor resembled that of normal placenta in rats. Part of the tumor has been transplanted and is now under observation.
INVOLVEMENT OF THE CENTRAL NERVOUS SYSTEM IN HAND‐SCHÜLLER‐CHRISTIAN DISEASE REPORT OF A CASE AND DISCUSSION ON THE ENTITY OF THE DISEASE–
Authors: Yamaguchi Kazuyoshi , Yokoyama Takeshi , Morimatsu Mitsunori
Published: December 2008

A case of Hand‐Schüller‐Christian disease with involvement of the central nervous system is reported. In addition to the visceral and bone lesions, the central nervous system were involved by granulomatous lesions with prominent astrocytic reaction and only few deposits of doubly retractile material in the form of foam cells.

Literatures of the reported cases of Hand‐Schüller‐Chrlstian disease with Involvement of central nervous system are reviewed.

Hand‐Schüller‐Christian disease is characterized by granulomatous lesion of the peripheral loose connective tissue of the organs where the lesions originate from the adventitial tissue. The major reticuloendothelial system organs such as the liver, spleen and lymph nodes are essentially spared. Deposition of cholesterol ester may be a secondary phenomenon. Hand‐Schüller‐Christian disease should be appreciated as a separate disease entity because of its particular pathomorphology.
LYMPHOSARCOMA OF JAWS RESEMBLING BURKITT'S TUMOR
Authors: Takagi Minoru , Ishikawa Goro
Published: December 2008

Six cases of lymphosarcoma originating as primaries in the jaws were selected from biopsy and autopsy materials of the Department of Oral Pathology, Tokyo Medical and Dental University, from 1963 through 1970. These cases are recognized as an unusual lymphosarcoma syndrome characterized by primary occurrence in the jaw bones, principally of children, the frequency of multiple origin from the molar regions, the relative infrequency of peripheral lymphadenopathy, the monotonous infiltration of undifferentiated lymphoid cells with the frequent appearance of a “starry sky” pattern, and a fulminant fatal course. These clinical and histological findings resemble those of poorly differentiated lymphosarcoma of Burkitt's type.
AN AUTOPSY CASE OF FABRY'S DISEASE**
Authors: Machinami Rikuo
Published: December 2008

An autopsy case of a 35‐year‐old male with Fabry's disease was Investigated histologically, electron microscopically and biochemically. Accumulation of both ceramide‐trihexoslde and ceramide‐dihexoside in the kidney, lymph nodes, nervous ganglion and spinal cord, as well as deficiency of α‐galactosldase in the kidney tissues were found. Electron microscopically the intracellular deposits presented diverse features including those with fingerprint‐like ultrastructure in the medullary cord reticulum cells which were alclan blue positive, rod‐shaped deposits of the capillary endothelial cells of the lymph nodes and several other types of deposits of the spinal ganglion cells.
REGIONAL ENTERITIS OF THE CECUM—A CLINICO‐PATHOLOGICAL STUDY—
Authors: AKAGI Tadaatsu , NIKKAKU Toshisuke , MOTOI Makoto , OGAWA Katsuo
Published: December 2008

A review of surgically resected materials of granulomatous or ulcerative entero‐colitis revealed 14 cases of regional enteritis primarily affecting the cecum (RE‐G), 11 cases of regional ileitis with cecal involvement, 10 cases of regional ileitis confined to the small intestine, 3 cases of regional enteritis of the large Intestine other than the cecum, 4 cases of perityphlitlc abscess or chronic perityphlitis, 2 cases of fibroplastic appendicitis, 11 cases of ulcerative colitis and 10 cases of Intestinal tuberculosis.

Clinical and pathological surveys were mainly focussed on RE‐G, comparing with regional Ileitis, intestinal tuberculosis and ulcerative colitis. The incidence of RE‐G was very high in contrast to that found in the literatures. The frequent clinical findings in RE‐G were abdominal pain, abdominal mass, elevation of erythrocyte sedimentation rate and previous appendectomy. The macroscopic findings were characterized by segmental distribution, marked thickening of bowel wall, narrowing of the lumen, Assuring and cobblestoning.

Microscopic findings of RE‐G were similar to regional Ileitis and were characterized by Assuring, abscess, lymphoid aggregates with lymph follicle formation and full‐wall inflammation. Noncaseating tubercles were diagnostic, but not common.
REACTION TO INJURIES IN THE BRAIN—AN ELECTRON MICROSCOPIC ANALYSIS OF ITS TOPOGRAPHICAL CHARACTERISTICS—
Authors: AKIMA Michio
Published: December 2008

An electron microscopic observation of the central nervous system of adult rabbits in normal and pathological conditions was performed from the view‐point of histological topography.

The meninges can be divided into 4 layers; 1st dural, 2nd subdural, 3rd meningothelial and 4th arachnoid layers, and the cellular components and responses of each layer were discussed in detail. The perivascular space of the penetrating vessels can be traced until the pia‐ glial border, but it is not clearly seen in the brain substance. An adventitial space containing adventitial cells and some collagen fibers is, however, recognized in the brain substance, and this is the site of proliferation of mesenchymal elements in various inflammatory conditions. The characteristics of degrading process in both the cerebral gray and white substances is also discussed. Through this investigation, an important role of the mesenchymo‐ectodermal junction in pathological conditions is emphasized, referring to the response of brain macrophages and perivascular astrocytes.
GENERALIZED CYTOMEGALIC INCLUSION DISEASE PRESENTING AN INFECTIOUS MONONUCLEOSIS SYNDROME (SO‐CALLED CYTOMEGALOVIRUS MONONUCLEOSIS) IN A PREVIOUSLY HEALTHY ADULT—AN AUTOPSY STUDY—
Authors: Ii Kunio , Hizawa Kazuo , Katsuse Eetsu
Published: December 2008

Autopsy study of generalized cytomegalic inclusion disease with distinct clinical manifestation of Paul‐Bunnel negative infectious mononucleosis in a previously healthy, 73 years old male revealed almost ubiquitous infiltration of lymphocyte and atypical lymphocyte in close association with existence of typical cytomegalic inclusion laden cells. Besides intense cytomegalovirus pneumonitis, hepatitis, orchitis and lesions in many other organs, similar cellular proliferation and infiltration were especially severe in the reticuloendothelial and hematopoietic systems including grossly only slightly enlarged lymphnodes, bone marrow and moderately swollen spleen. Lymphoproliferative response in these organs was outstanding, whereas reaction of reticulum cell and histiocyte was less marked. Such a peculiar distribution and nature of the lesion was thought to consist some morphological characteristics in this type of generalized cytomegalic inclusion disease.
AN AUTOPSY CASE OF MIXED DUST PNEUMOCONIOSIS
Authors: Kajita Akira , Hayashi Hisato , Mashiko Sachiko
Published: December 2008

A case of a 47‐year‐old female who died from severe pneumoconiosis, caused by prolonged exposure to dusts in a latex Industry, was described. Mineralogical composition of the lung dusts was qualitatively coincident with that of the dusting powder which the patient had used during her lifetime. It consisted mainly of sericite and quartz. The peculiarity of patho‐morphological features of pneumoconiotic change was discussed.
POST‐TRAUMATIC HYPOTHALAMIC OBESITY—AN AUTOPSY CASE—†
Authors: Miyasaki Kichihei , Miyachi Yokichi , Arimitsu Keiko , Kita Eiichi , Yoshida Muneyoshi
Published: December 2008

A 45‐year‐old housewife sustained a blow to the occipital region In a traffic accident about 2 years and 3 months prior to death. Autopsy revealed lesions of softening in the hypothalamus, left thalamus, frontal lobe (especially on the left), and base of the left temporal lobe. Following the head trauma, a marked Increase of appetite was noted, with obesity, hypogonadism, and mild elevation of temperature. No diabetes insipidus was noted whatsoever. Based on data from physical and pathological examination, the relationship between function and morphology in the human hypothalamus was discussed.
THE ELECTROPHORETIC CHANGES OF MAMMALIAN CELLS ASSOCIATED WITH MALIGNANT TRANSFORMATION
Authors: Yamada Takashi
Published: December 2008

The significance of electro kinetic properties of tumor cells can not be accurately assessed without also considering cytogenetic variations between cells and differences In their rates of proliferation. The original assumption that elevated charge densities and increased susceptibility to neuraminidase characterizing tumor cells in general, was confirmed mainly by observations of malignant hepatoma cells in the present study. It was also found that the only property common to both leukemic cells and other malignant cells was an increased susceptibility to neuraminidase. The immunological effects of host animals to the electrophoretic mobility in the transplantable tumor cells were also analysed.
HISTOPATHOLOGICAL CLASSIFICATION OF GASTRIC CARCINOMA FOR STANDARD REPORTING SYSTEM USED IN JAPAN
Authors: Takizawa Nobujiro
Published: December 2008

Analysis of approximately 2,000 cases of gastric carcinoma which survived for more than 5 years after gastrectomy revealed that the histopathological classification system proposed by the Japanese Society for Gastric Cancer Research had fair prognostic value and can be recommended for general use.
INDUCTION OF INTRACRANIAL TUMORS IN MICE BY HUMAN ADENOVIRUS TYPE 12
Authors: Murao Tsuyoshi
Published: December 2008

C3Hf/Bi mice inoculated intracranially with human adenovirus type 12 were studied by fluorescent antibody technique and light microscopy.

The cells with fluorescent T antigens were present in the wall of the ventricles and in the epithelium of the choroid plexuses. Tumors were induced in 21 of 45 mice and the predilection sites were the olfactory bulb, the floor of the fourth ventricle and the tapetum which was in contact with the hippocampus.

The relationship between production of the T antigen and tumor development as well as histological features of the tumors was discussed.
ENZYME HISTOCHEMICAL PROPERTY OF HUMAN LYMPH NODES – ITS IMMUNOLOGICAL INTERPRETATION –
Authors: Masubuchi Shigeo
Published: December 2008

Lymph nodes surgically removed from patients with various diseases were histochemically investigated. Enzymes examined were alkaline phosphatase (A1P), acid phosphatase (AcP), β‐glucuronidase (β‐G), and N‐acetyl‐/3‐glucosaminidase (NGa). On the other hand, adult albino rabbits and Wistar rats were immunized by horseradish peroxidase (HrP) mixed with Freund's complete adjuvant and the localizations of these enzymes, antigen HrP and its antibody in their regional lymph nodes at various stages of the immunization were investigated.

AIP in the human lymph nodes was mainly localized in the reticulum cells of the paracortical areas in a characteristic network pattern. This pattern was most prominent in the lymph nodes of SLE patients with elevated serum y‐globulin. In the regional lymph nodes of the albino rabbits immunized with HrP, both A1P and anti‐HrP antibody were localized along the processes of reticulum cells in the paracortical areas showing a similar network pattern.

The β‐G activity in the human lymph nodes was very intense and particulated in plasma cells and lymphocytes In the medullary cords and paracortical areas. The proliferation of these β‐G positive plasma cells and lymphocytes in the medullary cords and paracortical areas was most remarkable In SLE patients. In addition, the β‐G activity in these cell types responded most readily and steadily to the antigenic stimulation of HrP to both albino rabbits and Wistar rats.
EXTRACRANIAL METASTASIS OF INTRACRANIAL TUMOR – REVIEW OF LITERATURES and REPORT OF A CASE –
Authors: Wakamatsu Tadaie , Matsuo Takeshi , Kawano Shohichi , Teramoto Shigeyoshi , Matsumura Hidekatsu
Published: December 2008

There have been only two cases reported of intracranial tumor with extracranial metastasis through an artificial channel. The authors present another valid example of glioblastoma with distant metastases through a ventriculopleural shunt to the right thorax. With the review of the cases reported in the literature, they discuss such points as type of tumor, site of metastasis, survivial time, and latent period from onset, from operation, and from irradiation to an evidence of metastasis. The followings are considered: the long survival may certainly play a role but may be unnecessary for occurrence of extracranial metastases; surgical procedure and/or irradiation play an important role in glioblastoma; the bone is the most favored site of metastasis and the three major locations, namely bones, lung and pleura, and lymph nodes consist of more than three‐fourth of all metastatic sites; the metastatic ratio and its index are proposed by the authors for further discussion; there are many factors concerning the occurrence of extracranial metastases of intracranial tumors, but some factors are merely theoretical.
AN AUTOPSY CASE OF CRONKHITE‐CANADA'S SYNDROME ‐GENERALIZED GASTROINTESTINAL POLYPOSIS, PIGMENTATION, ALOPECIA and ONYCHOTROPHIA –
Authors: Shibuya Chiken
Published: December 2008

A case of Cronkhite‐Canada's syndrome characterized by diffuse gastrointestinal polyposis, alopecia, nail atrophy, and pigmentation of the skin is reported. These ectodermal changes are probably a part of a generalized nutritional deficiency state and their clinical prominence may be related to the extensive involvement of all segments of the digestive tract. The macroscopic findings of the gastrointestinal tract were different at various sites, but the microscopic picture was uniform and characterized by proliferation of mucus secreting glands and cyst‐like dilations of the gland excepting the cancerous lesions of the sigmoid and rectum. The etiology of the syndrome remains obscure.
RETICULUM CELL SARCOMA OF THE BREAST – AN AUTOPSY CASE WITH TERMINAL LEUKEMIC MANIFESTATION –
Authors: Matsuyama Mutsushi , Hoshino Munemitsu , Suchi Taisan , Kurita Soji , Sato Tsuneko , Suzuki Harumi , Takagi Iwao , Murakami Minoru , Takeuchi Shinji
Published: December 2008

An autopsy case of rapidly growing reticulum cell sarcoma of the breast with terminal leukemic manifestation and wide disseminations, including bilateral ovarian involvement, is reported. Metastatic tumors in the lymph nodes and in the right chest wall were sensitive for bleomycin, the combined chemotherapies with Mitomycin C, 5‐FU, and Cytosine Arabinoside, and with Vincristine, Endoxan, 6MP, and prednisolone, and radiation therapy by Lineac, but only a short survival was finally obtained. The histology of the tumors is characterized by single cell pattern with medium sized polygonal cells. Investment of reticular fibrils by the cytoplasm of the tumor cells is revealed by electron microscopy.
THE BEHAVIOUR OF LYMPHOGENEOUSLY GIVEN ANTIGEN IN THE LYMPH NODE THE LOCALIZATION OF GIVEN ANTIGEN and NEWLY FORMED ANTIBODY
Authors: Yamaguchi Hisao , Fukuda Junya , Baba Kensuke , Takeuchi Hiroshi , Kageyama Keizo
Published: December 2008

The vascular structures in the lymph node and their relation to fluid exchange have been reported in previous communications and it was considered that the morphological changes of the vascular structures were closely correlated with the functional development of lymph nodes as an antibody forming organ. In order to clarify the localization of the given antigen and newly formed antibody in relation to the morphological structure of lymph nodes, the popliteal lymph nodes of rabbits were studied by immuno‐fluorescent techniques.

The antibody was found in the pavement arrangement (solid) of reticulum tissue which was formed by the expel of lymphocytes in the cortical mass and by the morphofunctional alterations of the reticulum cells. The given antigen and newly formed antibody were never detected in the follicles throughout the period of this experiment. ACTA PATH. JAP. 22:427–440, 1972.
STUDIES ON THE MORPHOLOGICAL CHANGES OF ARTERY CAUSED BY EXUDATION – INITIAL CHANGES OF ARTERITIS
Authors: Yamaguchi Hisao , Nakajima Sohta , Torikata Chikao , Takeuchi Hiroshi , KAGEYAMA Keizo
Published: December 2008

The morphological changes of the mesenterial arteries of guinea pig were studied with the administration of intravascular or intraperitoneal injection of soluble immune complexes. The main change consisted of vacuolar alteration of arterial endothelium. This was considered to have been caused by a regurgitation mechanism of the exudated plasma across the arterial wall and is the initial morphologic change of so‐called allergic vasculitis. ACTA PATH. JAP. 22:441–455, 1972.
STUDIES ON THE MORPHOLOGICAL CHANGES OF THE LARGE VEIN WITH HYALURONIDASE ADMINISTRATION
Authors: Yamaguchi Hisao , Torikata Chikao , Kageyama Keizo
Published: December 2008

This report is concerned with the studies on the changes of the intimal elastic lamella and the intermuscular matrix with the administration of hyaluronidase which is thought to have the enzymatic activities for the decrease of the viscosity of acid mucopolysaccharide by way of depolymerlsation. With the administration of hyaluronidase, the remarkable morphological changes of Internal elastic lamella and the intercellular matrix of the large vein were demonstrated. ACTA PATH. JAP. 22:457–464, 1972.
EXPERIMENTAL STUDY ON THE MECHANISMS OF DELAYED HYPERSENSITIVITY REACTION, WITH SPECIAL REFERENCE TO EMIGRATION and FUNCTION OF MONONUCLEAR CELLS*
Authors: Kambara Takeshi , Katsuya Hiroaki , Maeda Shozo
Published: December 2008

Delayed hypersensitivity reaction is characterized by Infiltration of mononuclear cells (macrophages and lymphocytes). The mechanisms of emigration and function of mononuclear cells in local skin lesions were studied in experimental tuberculosis. A chemotactlc activity for mononuclear cells was found in the extract of tuberculin skin sites, and proteases active at pH 3, 6, and 9 were found in the extract and partially purified using ammonium sulfate and column chromatography. Relationship between chemotactlc activity and protease activities was discussed. Similar protease activities were found in the extract of sensitized lymph node cells, and proteases active at pH 6 and 9 were increased when homo‐genate of sensitized lymph node cells was Incubated with PPD for 3 hours at 37°C. It appears that PPD could concern to release protease from sensitized lymphocytes and involve in delayed hypersensitivity reactions. The role of mononuclear cells in tuberculous skin lesions were studied in the sense of bacteriocidal activity for tubercle bacilli. Certain macrophages in the skin lesions were produced locally by cell division. Macrophages in granulation tissue around necrotic foci were specifically matured and strongly active for/9‐galactosidase, and the number of acid fast bacilli in macrophages and the intensity of staining for /3‐galactosidase were reversely correlated. This was also confirmed in irradiated rabbits with 400 rads of whole body radiation. These findings suggest that high levels of lysosomal enzymes are involved in destruction of bacilli.
A PATHOLOGICAL STUDY ON THE JUVENILE TYPE OF CHRONIC MYELOID LEUKEMIA
Authors: Takanashi Riichiro
Published: December 2008

The pathological findings In four infants with chronic myeloid leukemia (GML) of the juvenile type were compared with those in adults with GML. In three cases Hb‐F of erythrocytes was positive and Ph1 chromosome was negative. In one case these examinations were not performed.

The bone marrow shows a wide range of maturation of granulocytes in both types. Immature forms, however, are more abundant in the juvenile type than in the adult type. Advanced structural alteration as splenoid marrow is rare in the juvenile type. Decrease of megakaryocytes is more profound than that of erythroblasts. Involvement of lymph node and lymphatic apparatus is much more extensive in the juvenile type than in the adult type. Proliferation of erythroblasts is prominent in foci of extramedullary infiltration, frequently showing a nodular pattern.

For examination of Hb‐F of erythrocytes in formol‐flxed paraffin sections, alkali denaturatlon followed by spectrophotometry with UMSP‐I was applied. The denaturatlon rate of erythrocytes In the liver is lower In the juvenile type of GML than in the control adults and adult type of CML. ACTA PATH. JAP. 22:489–508, 1972.
ELECTRON MICROSCOPIC STUDY OF THE AUER BODY
Authors: Fukushi Katsuhisa , Nakasato Norio , Nabita Noriko , Yoshida Kosaku
Published: December 2008

The peripheral blood of four patients with acute myelogenous leukemia was used to study the relationship between the granules and the Auer bodies. Electron microscopic observation revealed the picture of fusion of these organelles. Pictures such as an unusually developed granule with changed internal structure, and the developmental process of the Auer body were observed. It was concluded that the origin of the Auer body was a granule, as previously reported, and they were classified into three types according to their different internal structures. No particular relation between the size of the granule and the degree of electron density was noticed, though some authors Indicated that the size of the granule was related to the electron density. Several microtubules with diameter of 60 A which run parallel to each other were frequently seen In the granules. It was not clarified as to what kind of granule corresponded to the azur granule in this study. ACTA PATH. JAP. 22:509–515, 1972.
ARGYROPHIL CELL CARCINOID OF THE STOMACH ‐A LIGHT‐ and ELECTRON‐MICROSCOPIC OBSERVATION‐
Authors: Soga Jun , Tazawa Kenji , Wada Kanji , Fujimaki Masao , Saito Kyoko , Ikabashi Kiyoshi
Published: December 2008

A case of argyrophil cell, B type, carcinoid of the stomach In a 36‐year‐old male is presented. The patient had no special clinical manifestations as to carcinoid syndrome, and the biochemical analysis on the preoperative urine and blood and on the tumor tissue itself failed to disclose significant increase in either active or end products of corresponding amines. Diagnosis was based merely on morphological findings including those of silver impregnations of both argentaffin and argyrophil reactions and electron‐microscopic demonstration of the specific secretory granules. The importance of preoperative diagnosis by all possible means on cases such as ours is our special emphasis in order to obtain correlative analysis of silver reactions and biochemistry along with electron‐microscopy. ACTA PATH. JAP. 22:541–553. 1972.
POST‐STEROID PANNICULITIS WITH CEREBRAL VASCULAR and PULMONARY COMPLICATIONS—REPORT OF AN AUTOPSY CASE
Authors: Hirokawa K. , Nishido T. , Okuda M.
Published: December 2008

An autopsy case report was made on a 28‐year‐old female who had systemic nodular panniculitis, necrotizing arteritis of the cerebral artery and unusual pulmonary lipogranuloma after massive, long‐term administration of corticosteroids for nephrotic syndrome. Panniculitis in this case was fairly consistent with the category of post‐steroid panniculitis and was thought to be the first adult case, of post‐steroid panniculitis developing in the internal as well as subcutaneous adipose tissue. The other two lesions in the brain and the lung above mentioned might be also regarded as adverse effects of corticosteroid therapy. The subcutaneous nodular lesion was studied chemically and histochemically, and the genesis of nodular panniculitis in this case was discussed as compared with sclerema neonatorum.
CAPILLARY HEMATOCRIT METHOD COMBINED WITH MICROSCOPICAL OBSERVATION AND ITS APPLICATION TO A QUICK SCREENING OF RAT LEUKEMIA
Authors: Sugiyama Taketoshi
Published: December 2008

The structure of buffy coat from normal and leukemia rats was studied. Normal buffy coat in a microhematocrit tube showed a distinct stratified structure consisting of leucocytes, platelets, and leucocyte debris from the bottom to the top. Two distinct layers were further identified in the leucocyte layer in many rats. They were composed of polymorphonuclear leucocytes (bottom) and lymphocytes (top). From the prominent change in the thickness of each layer during 7,12‐dimethylbenz(a)anthracene leukemogenesis, this technique was shown to be useful for screening, follow‐up, and classification of the leukemia in this experimental system.