bluuebunny/crossref_metadata_2025 huggingface dataset:
Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons
Authors: Li Zhuting , Cogswell Meaghan , Hixson Kathryn , Brooks-Kayal Amy R. , Russek Shelley J.
Published: May 2018

While the exact role of β1 subunit-containing GABA-A receptors (GABARs) in brain function is not well understood, altered expression of the β1 subunit gene (GABRB1) is associated with neurological and neuropsychiatric disorders. In particular, down-regulation of β1 subunit levels is observed in brains of patients with epilepsy, autism, bipolar disorder, and schizophrenia. A pathophysiological feature of these disease states is imbalance in energy metabolism and mitochondrial dysfunction. The transcription factor, nuclear respiratory factor 1 (NRF-1), has been shown to be a key mediator of genes involved in oxidative phosphorylation and mitochondrial biogenesis. Using a variety of molecular approaches (including mobility shift, promoter/reporter assays, and overexpression of dominant negative NRF-1), we now report that NRF-1 regulates transcription of GABRB1 and that its core promoter contains a conserved canonical NRF-1 element responsible for sequence specific binding and transcriptional activation. Our identification of GABRB1 as a new target for NRF-1 in neurons suggests that genes coding for inhibitory neurotransmission may be coupled to cellular metabolism. This is especially meaningful as binding of NRF-1 to its element is sensitive to the kind of epigenetic changes that occur in multiple disorders associated with altered brain inhibition.
Long-distance communication in synthetic bacterial consortia through active signal propagation
Authors: Parkin James M. , Murray Richard M.
Published: May 2018

A synthetic cell-cell signaling circuit should ideally be (1) metabolically lightweight, (2) insulated from endogenous gene networks, and (3) excitable rather than oscillatory or bistable. To accomplish these three features, we propose a synchronized pulse-generating circuit based on the design of published synchronized oscillators. This communication module employs a pulse generator built using Lux-type quorum sensing components and an IFFL transcriptional circuit. Both the input and output of this module are AHLs, the quorum sensing signaling molecule. Cells bearing this module therefore act as an excitable medium, producing a pulse of AHL when stimulated by exogenous AHL. Using simulation and microscopy, we demonstrate how this circuit enables traveling pulses of AHL production through microcolonies growing in two dimensions. Traveling pulses achieve cell-cell communication at longer distances than can be achieved by diffusion of signal from sender to receiver cells and may permit more sophisticated coordination in synthetic consortia.
A graph-based algorithm for RNA-seq data normalization
Authors: Tran Diem-Trang T. , Bhaskara Aditya , Might Matthew , Kuberan Balagurunathan
Published: May 2018

The use of RNA-sequencing has garnered much attention in the recent years for characterizing and understanding various biological systems. However, it remains a major challenge to gain insights from a large number of RNA-seq experiments collectively, due to the normalization problem. Current normalization methods are based on assumptions that fail to hold when RNA-seq profiles become more abundant and heterogeneous. We present a normalization procedure that does not rely on these assumptions, or on prior knowledge about the reference transcripts in those conditions. This algorithm is based on a graph constructed from intrinsic correlations among RNA-seq transcripts and seeks to identify a set of densely connected vertices as references. Application of this algorithm on our benchmark data showed that it can recover the reference transcripts with high precision, thus resulting in high-quality normalization. As demonstrated on a real data set, this algorithm gives good results and is efficient enough to be applicable to real-life data.

2012 ACM Subject Classification

Applied computing → Computational transcriptomics, Applied computing → Bioinformatics

Digital Object Identifier

10.4230/LIPIcs.WABI.2018.xxx

Funding

This material was based on research supported by the National Heart, Lung, and Blood Institute (NHLBI)–NIH sponsored Programs of Excellence in Glycosciences [grant number HL107152 to B.K.], and partially by NSF [CAREER grant 1350344 to M.M.]. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon.
Recurrent connections between CA2 pyramidal cells
Authors: Okamoto Kazuki , Ikegaya Yuji
Published: May 2018

Recurrent excitatory synapses are shown theoretically to play roles in memory storage and associative learning, and such recurrent synapses are well described to occur in the CA3 region of the hippocampus. Here, we report that the CA2 region also contains recurrent excitatory monosynaptic couplings. Using dual whole-cell patch-clamp recordings from CA2 pyramidal cells in mouse hippocampal slices under differential interference contrast microscopic controls, we evaluated monosynaptic excitatory connections. Unitary excitatory postsynaptic potentials occurred in 1.4% of 502 cell pairs. These connected pairs were located preferentially in the superficial layer and proximal part (CA2b) of the CA2 region. These results indicate that recurrent excitatory circuits are dense in the CA2 region as well as in the CA3 region.
Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness
Authors: Matheson Granville James , Plavén-Sigray Pontus , Louzolo Anaïs , Borg Jacqueline , Farde Lars , Petrovic Predrag , Cervenka Simon
Published: May 2018

The dopamine D1 receptor (D1R) is thought to play a role in psychosis and schizophrenia, however the exact nature of this involvement is not clear. Positron emission tomography studies comparing D1R between patients and control subjects have produced inconsistent results. An important confounding factor in most clinical studies is previous exposure to antipsychotic treatment, which is thought to influence the density of D1R. To circumvent some of the limitations of clinical studies, an alternative approach for studying the relationship between D1R and psychosis is to examine individuals at increased risk for psychotic disorders, or variation in subclinical psychotic symptoms such as delusional ideation within the general population, referred to as psychosis proneness traits. In this study, we investigated whether D1R availability is associated with delusional ideation in healthy controls using data from 76 individuals measured with PET using [11C]SCH23390 and 217 individuals who completed delusional ideation questionnaires, belonging to three different study cohorts. We first performed exploratory, hypothesis-generating, analyses by creating and evaluating a new measure of delusional ideation (n=132 and n=27), which was then found to show a negative association with D1R availability (n=24). Next, we performed confirmatory analyses using Bayesian statistical modelling, in which we first attempted to replicate this result (n=20), and then evaluated the association of Peters Delusion Inventory scores with D1R availability in two independent cohorts (n=41 and 20). Collectively, we found strong evidence that there is little to no linear association between delusional ideation and D1R availability in healthy controls. If differences in D1R can be confirmed in drug-naive schizophrenia patients compared to controls, further studies are needed to ascertain whether these changes occur at the onset of psychotic symptoms or if they are associated with specific behavioural or genetic aspects of psychosis proneness other than delusional ideation.
Psychometric properties of the PHQ-9 depression scale in people with multiple sclerosis: a systematic review
Authors: Patrick Sarah , Connick Peter
Published: May 2018

Background

Depression affects approximately 25% of people with MS (pwMS) at any given time. It is however under recognised in clinical practice, in part due to a lack of uptake for brief assessment tools and uncertainty about their psychometric properties. The 9-item Patient Health Questionnaire (PHQ-9) is an attractive candidate for this role.

Objective

To synthesise published findings on the psychometric properties of the 9-item Patient Health Questionnaire (PHQ-9) when applied to people with multiple sclerosis (pwMS).

Data sources

PubMed, Medline and ISI Web of Science databases, supplemented by hand-searching of references from all eligible sources.

Study eligibility criteria

Primary literature written in English and published following peer-review with a primary aim to evaluate the performance of the PHQ-9 in pwMS.

Outcome measures

Psychometric performance with respect to appropriateness, reliability, validity, responsiveness, precision, interpretability, acceptability, and feasibility.

Results

Seven relevant studies were identified, these were of high quality and included 5080 participants from all MS disease-course groups. Strong evidence was found supporting the validity of the PHQ-9 as a unidimensional measure of depression. Used as a screening tool for major depressive disorder (MDD) with a cut-point of 11, sensitivity was 95% sensitivity and specificity 88.3% (PPV 51.4%, NPV 48.6%). Alternative scoring systems that may address the issue of overlap between somatic features of depression and features of MS per se are being developed, although their utility remains unclear. However data on reliability was limited, and no specific evidence was available on test-retest reliability, responsiveness, acceptability, or feasibility.

Conclusions

The PHQ-9 represents a suitable tool to screen for MDD in pwMS. However use as a diagnostic tool cannot currently be recommended, and the potential value for monitoring depressive symptoms cannot be established without further evidence on test-retest reliability, responsiveness, acceptability, and feasibility.

PROSPERO register ID: CRD42017067814
Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis
Authors: Ugarte-Berzal Estefania , Berghmans Nele , Boon Lise , Martens Erik , Vandooren Jennifer , Cauwe Bénédicte , Thijs Greet , Proost Paul , Damme Jo Van , Opdenakker Ghislain
Published: May 2018

Gelatinase B/matrix metalloproteinase-9 (MMP-9) triggers multiple sclerosis (MS) and the animal model of experimental autoimmune encephalomyelitis (EAE) by the breakdown of the blood-brain barrier. Interestingly, MMP-9 is beneficial in systemic autoimmunity caused by Fas-deficiency. Fas-deficient (faslpr)and Fas-ligand-deficient mice are protected against EAE. We here investigated the interaction between Fas and MMP-9 in the setting of induction of EAE and compared short- and long-term effects. We provoked EAE with myelin oligodendrocyte glycoprotein (MOG) peptide and compared EAE development in four genotypes (wild-type (WT), single knockoutmmp-9−/−,faslpr, andmmp-9−/−/faslpr) and monitored leukocytes, cytokines and chemokines as immunological parameters. As expected,faslprmice were resistant against EAE induction, whereas MMP-9 single knockout mice were not. In the doublemmp-9−/−/faslprmice the effects on disease scores pointed to independent rather than interrelated disease mechanisms. On a short term, leukocytes infiltrated into the brain and cytokines and chemokines after EAE induction were significantly higher in all the four genotypes studied, even in thefaslprandmmp9-/-/faslpr, which did not develop clinical disease. The levels of MMP-9 but not of MMP-2 were increased in the brain and in the peripheral organs after EAE induction. After 40 days all the animals recovered and did not show signs of EAE. However, the absence of MMP-9 in the remission phase suggested a protective role of MMP-9 in the late phase of the disease, thus singlemmp-9−/−mice presented a delayed onset and remission in comparison with WT animals suggesting a phase-dependent role of MMP-9 in the disease. Nevertheless, the levels of some cytokines and chemokines were remained higher than in control animals even 100 days after EAE induction, attesting to a prolonged state of immune activation. We thus yielded new insights and useful markers to monitor this activated immune status. Furthermore, MMP-9 but not MMP-2 levels remained increased in the brains and, to a higher extend, in the spleens of the WT mice even during the remission phase, which is in line with the role of MMP-9 as a useful marker and a protective factor for EAE in the remission phase.
GraphSeq: Accelerating String Graph Construction for De Novo Assembly on Spark
Authors: Su Chung-Tsai , Chang Ming-Tai , Cheng Yun-Chian , Li Yun-Lung , Wang Yao-Ting
Published: May 2018

Summary: De novo genome assembly is an important application on both uncharacterized genome assembly and variant identification in a reference-unbiased way. In comparison with de Brujin graph, string graph is a lossless data representation for de novo assembly. However, string graph construction is computational intensive. We propose GraphSeq to accelerate string graph construction by leveraging the distributed computing framework.

Availability and Implementation: GraphSeq is implemented with Scala on Spark and freely available at https://www.atgenomix.com/blog/graphseq.

Supplementary information: Supplementary data are available at Bioinformatics online.
Photoperiod sensing of the circadian clock is controlled by EARLY FLOWERING 3 and GIGANTEA
Authors: Anwer Muhammad Usman , Davis Amanda , Davis Seth Jon , Quint Marcel
Published: May 2018

ELF3 and GI are two important components of the Arabidopsis circadian clock. They are not only essential for the oscillator function but are also pivotal in mediating light inputs to the oscillator. Lack of either results in a defective oscillator causing severely compromised output pathways, such as photoperiodic flowering and hypocotyl elongation. Although single loss of function mutants of ELF3 and GI have been well-studied, their genetic interaction remains unclear. We generated an elf3 gi double mutant to study their genetic relationship in clock-controlled growth and phase transition phenotypes. We found that ELF3 and GI repress growth differentially during the night and the day, respectively. Circadian clock assays revealed that ELF3 and GI are essential Zeitnehmers that enable the oscillator to synchronize the endogenous cellular mechanisms to external environmental signals. In their absence, the circadian oscillator fails to synchronize to the light-dark cycles even under diurnal conditions. Consequently, clock-mediated photoperiod-responsive growth and development is completely lost in plants lacking both genes, suggesting that ELF3 and GI together convey photoperiod sensing to the central oscillator. Since ELF3 and GI are conserved across flowering plants and represent important breeding and domestication targets, our data highlight the possibility of developing photoperiod-insensitive crops by adjusting the allelic combination of these two key genes.

One sentence summary

ELF3 and GI are essential for circadian clock mediated photoperiod sensing.
Prenatal growth map of the mouse knee joint by mean of deformable registration technique
Authors: Giorgi Mario , Sotiriou Vivien , Fanchini Niccolo’ , Conigliaro Simone , Bignardi Cristina , Nowlan Niamh C. , Dall’Ara Enrico
Published: May 2018

Joint morphogenesis is the process during which distinct and functional joint shapes emerge during pre- and post-natal joint development. In this study, a repeatable semi-automatic protocol capable of providing a 3D realistic developmental map of the prenatal mouse knee joint was designed by combining Optical Projection Tomography imaging (OPT) and a deformable registration algorithm (Sheffield Image Registration toolkit, ShIRT). Eleven left limbs of healthy murine embryos were scanned with OPT (voxel size: 14.63¼m) at two different stages of development: Theiler stage (TS) 23 (approximately 14.5 embryonic days) and 24 (approximately 15.5 embryonic days). One TS23 limb was used to evaluate the precision of the displacement predictions for this specific case. The remaining limbs were then used to estimate Developmental Tibia and Femur Maps. Acceptable uncertainties of the displacement predictions were found for both epiphyses (between 0.7 and 1.4 μm, along all directions and anatomical sites) for nodal spacing of 1 voxel. The protocol was found to be reproducible with maximum Modified Housdorff Distance differences equal to 1.9 μm and 1.5 μm for the tibial and femoral epiphyses respectively. The effect of the initial shape of the rudiment affected the developmental maps by 21.7 μm and 21.9 μm for the tibial and femoral epiphyses respectively, which correspond to 1.4 and 1.5 times the voxel size. To conclude, this study proposes a repeatable semi-automatic protocol capable of providing mean 3D realistic developmental map of a developing rudiment allowing researchers to study how growth and adaptation are directed by biological and mechanobiological factors.
On the importance of accounting for intraspecific genomic relatedness in multi-species studies
Authors: Joly Simon , Flynn Dan F. B. , Wolkovich Elizabeth
Published: May 2018

Analyses in many fields of ecology are increasingly considering multiple species and multiple individuals per species. Premises of statistical tests are often violated with such datasets because of the non-independence of residuals due to phylogenetic relationships or intraspecific population structure. If comparative approaches that account for the phylogenetic relationships of species are well developed and their benefits demonstrated, the importance of considering the intraspecific genetic structure, especially in combination with the phylogenetic structure, has rarely been addressed.

We investigated whether it is beneficial to account for intraspecific genomic relatedness in multi-species studies. For this, we used a Phylogenetic Mixed Model to analyze first a suite of simulated data and then results from one example ecological study—a budburst experiment where clippings of 10 tree and shrub species were subjected to different temperatures and photoperiods.

We found that accounting for intraspecific genetic structure yields more accurate and precise fixed effects as well as increased statistical power, but more so when the relative importance of the intraspecific to the phylogenetic genetic structure is greater. Analysis of the budburst experiment further showed that accounting for intraspecific and phylogenetic structures yields improved estimates of warming and photoperiod effects and their interaction in explaining the time to budburst.

Our results show that statistical gains can be made by incorporating information on the intraspecific genomic relatedness of individuals in multi-species studies. This is relevant for investigations that are interested in intraspecific variation and that plan to include such observations in statistical tests.
Somatic Mutations Render Human Exome and Pathogen DNA more Similar
Authors: Ebrahimzadeh Ehsan , Engler Maggie , Tse David , Cristescu Razvan , Tchamkerten Aslan
Published: May 2018

Immunotherapy has recently shown important clinical successes in a substantial number of oncology indications. Additionally, the tumor somatic mutation load has been shown to associate with response to these therapeutic agents, and specific mutational signatures are hypothesized to improve this association, including signatures related to pathogen insults. We sought to study in silico the validity of these observations and addressed three questions. First, we investigated whether somatic mutations typically involved in cancer may increase, in a statistically meaningful manner, the similarity between common pathogens and the human exome. Our study shows that specific common mutagenic processes like those resulting from exposure to ultraviolet light (in melanoma) or smoking (in lung cancer) induce, in the upper range of biologically plausible frequencies, peptides in the cancer exome that are statistically more similar to pathogen peptides than the normal exome. Second, we investigated whether this increased similarity is due to the specificities of the mutagenic process or uniformly random mutations at equal rate would trigger the same effect. For certain pathogens the increased similarity is more pronounced for specific mutagenic processes than for uniformly random mutations and for other pathogens the effects cannot be distinguished. Finally, we investigated whether specific mutational processes result in amino-acid changes with functional relevance that are more likely to be immunogenic. We showed that functional tolerance to mutagenic processes across species generally suggests more resilience to natural processes than to denovo mutagenesis. These results support the idea that recognition of pathogen sequences as well as differential functional tolerance to mutagenic processes may play an important role in the immune recognition process involved in tumor infiltration by lymphocytes.
DeepEM: Deep 3D ConvNets With EM For Weakly Supervised Pulmonary Nodule Detection
Authors: Zhu Wentao , Vang Yeeleng S. , Huang Yufang , Xie Xiaohui
Published: May 2018

Recently deep learning has been witnessing widespread adoption in various medical image applications. However, training complex deep neural nets requires large-scale datasets labeled with ground truth, which are often unavailable in many medical image domains. For instance, to train a deep neural net to detect pulmonary nodules in lung computed tomography (CT) images, current practice is to manually label nodule locations and sizes in many CT images to construct a sufficiently large training dataset, which is costly and difficult to scale. On the other hand, electronic medical records (EMR) contain plenty of partial information on the content of each medical image. In this work, we explore how to tap this vast, but currently unexplored data source to improve pulmonary nodule detection. We propose DeepEM, a novel deep 3D ConvNet framework augmented with expectation-maximization (EM), to mine weakly supervised labels in EMRs for pulmonary nodule detection. Experimental results show that DeepEM can lead to 1.5% and 3.9% average improvement in free-response receiver operating characteristic (FROC) scores on LUNA16 and Tianchi datasets, respectively, demonstrating the utility of incomplete information in EMRs for improving deep learning algorithms.1
NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes
Authors: Fei Jia , Ishii Haruhiko , Hoeksema Marten A. , Meitinger Franz , Kassavetis George A. , Glass Christopher K. , Ren Bing , Kadonaga James T.
Published: May 2018

Our understanding of transcription by RNA polymerase II (Pol II) is limited by our knowledge of the factors that mediate this critically important process. Here we describe the identification of NDF, a nucleosome-destabilizing factor that facilitates Pol II transcription in chromatin. NDF has a PWWP motif, interacts with nucleosomes near the dyad, destabilizes nucleosomes in an ATP-independent manner, and facilitates transcription by Pol II through nucleosomes in a purified and defined transcription system as well as in cell nuclei. Upon transcriptional induction, NDF is recruited to the transcribed regions of thousands of genes and colocalizes with a subset of H3K36me3-enriched regions. Notably, the recruitment of NDF to gene bodies is accompanied by an increase in the transcript levels of many of the NDF-enriched genes. In addition, the global loss of NDF results in a decrease in the RNA levels of many genes. In humans, NDF is present at high levels in all tested tissue types, is essential in stem cells, and is frequently overexpressed in breast cancer. These findings indicate that NDF is a nucleosome-destabilizing factor that is recruited to gene bodies during transcriptional activation and facilitates Pol II transcription through nucleosomes.
Risk implications from the selection of rainfall index insurance intervals
Authors: Westerhold Ashlee , Walters Cory , Brooks Kathleen , Vandeveer Monte , Volesky Jerry , Schacht Walter
Published: May 2018

Purpose

The purpose of this paper is to empirically examine the financial outcomes from forage production and RI-PRF insurance interval for two locations in Nebraska. Both locations provide historical forage production and precipitation data, allowing the authors to examine the relation between RI-PRF net income and forage production.

Design/methodology/approach

The authors focus on evaluating the producer net income and risk (measured as variance of net income) by examining the relation between farm precipitation and production and comparing multiple insurance intervals to no insurance. Each insurance interval will likely have a different relation (basis risk) between observed production and return from insurance and, therefore, a different impact on the variance of net incomes. The impact on variance of net incomes identifies the risk-reducing aspects of RI-PRF insurance intervals. The authors then rank each scenario into four mutually exclusive zones that describe the risk-reducing effectiveness and whether the subsidy is working correctly.

Findings

The authors found both risk increasing and decreasing insurance intervals exist at both locations. One insurance scenario (low in BBR) provided the highest net income while increasing risk, suggesting a profit maximizing opportunity. RI-PRF reduces net income risk with intervals insuring during high expected precipitation (growing season); while net income risk increases with intervals insuring low expected precipitation (non-growing season, winter months). The farmer would want to insure during the high expected precipitation months, which coincides with the growing season, since RI-PRF lowers the net income risk. For the government, removing net income risk increasing intervals improves the allocation of government resources.

Originality/value

In this paper, the authors modeled the relation between RI-PRF interval selection using the historical forage production data at two locations in Nebraska. The use of historical forage production data allowed the authors to precisely identify the risk-reducing effectiveness of RI-PRF interval selection.
Building firm capability through imitative innovation: Chinese manufacturing SME cases
Authors: Si Steven , Wang Song , Welch Steven M.
Published: May 2018

Purpose

This study aims to investigate how firm capability can be accumulated with the inputs of learning efforts targeted at resolving barriers existing in the imitative innovation process. This paper takes imitative innovation as a process involving a few stages during which learning efforts are targeted at overcoming barriers existing within each process.

Design/methodology/approach

The multiple case study approach has been adopted to explore how Chinese manufacturing small and medium enterprises (SMEs) learn and increase their technological capabilities through a continuous process of product refinement and improvement based on imitative innovation. In particular, the authors accentuate the learning efforts that firms must make to cope with various technological barriers

Findings

It is revealed that during the initial stages of imitative innovation, the organizational learning of Chinese manufacturing SMEs is highly constrained by the limitations of their technological resources and capabilities. It is also found that original equipment manufacturers can play an important role in providing Chinese learners with both explicit and tacit technological knowledge.

Originality/value

This study investigates how firm capability can be accumulated with the inputs of learning efforts targeted at resolving barriers existing in the imitative innovation process. The multiple case study approach has been adopted to explore how Chinese manufacturing SMEs learn and increase their technological capabilities through a continuous process of product refinement and improvement based on imitative innovation that could add new and great value to this research area.
Brokers or platforms? A longitudinal study of how hybrid interorganizational partnerships for regional innovation deal with VUCA environments
Authors: Ungureanu Paula , Bertolotti Fabiola , Macri Diego
Published: May 2018

Purpose

The purpose of this paper is to investigate the role played by turbulent environments in the evolution of hybrid (i.e. multi-party, cross-sector) partnerships for regional innovation. Although extant research suggests that organizations decide to participate in such partnerships to cope with their turbulent environments, little is known about how actual perceptions of turbulent environments influence the setup and evolution of a partnership.

Design/methodology/approach

The qualitative study adopts a longitudinal design to investigate the evolution of a cross-sector regional innovation partnership between ten very different organizations. With the help of the VUCA (volatility, uncertainty, complexity and ambiguity) model proposed by Bennett and Lemoine (2014a), the authors study the relation between partners’ initial perceptions of environmental turbulence and the models adopted for the partnership throughout its lifecycle (emergent, brokering and platform).

Findings

The authors show that partners’ intentions to solve perceived environmental turbulence through collaboration can have the unexpected consequence of triggering perceived turbulence inside the collaboration itself. Specifically, the authors show that perceived partnership VUCA at each stage is a result of partners’ attempts to cope with the perceived VUCA in the previous stage.

Practical implications

The study highlights a set of common traps that both public and private organizations engaged in hybrid partnerships might fall into precisely as they try to lower VUCA threats in their environments.

Originality/value

The work accounts for the relationship between external and internal perceptions of VUCA in hybrid partnerships for regional innovation, and, in particular, provides a better understanding of what happens when organizations choose to enter hybrid partnerships in order to deal with perceived threats in their environments.
Factors affecting student use of Web-based services
Authors: Arif Muhammad , Ameen Kanwal , Rafiq Muhammad
Published: May 2018

Purpose

The delivery of information services in higher education is increasingly relying on Web-based systems. The low adoption and underutilization of information systems have been major problems for developing countries such as Pakistan in terms of realizing their full benefits. This study aims to investigate factors affecting student use of Allama Iqbal Open University’s (AIOU) Web-based services by using the Unified Theory of Acceptance and Use of Technology (UTAUT) from the perspective of Pakistani distance education.

Design/methodology/approach

This study has adopted quantitative research design with the UTAUT model as a theoretical framework. A self-completion structured questionnaire-based survey has been administered to 388 master’s level students, selected through systematic sampling from the target population. The response rate was 82 per cent (318). All statistical tests have been performed using IBM SPSS (version 20.0) and Process macro for SPSS.

Findings

Findings of the model’s hypotheses reveal that performance expectancy, effort expectancy and social influence are significant predictors of student behavioural intention to use AIOU Web-based services, whereas actual student use is dependent on facilitating conditions and student behavioural intention to use. The impact of moderating variables with respect to age, gender and experience did not influence the actual use of the Web services. However, the research model significantly measured (62.1 per cent) the actual use of AIOU Web-based services by the students.

Research limitations/implications

This study is delimited to the UTAUT model to investigate the phenomena. Besides this, the context of the study is the voluntary instead of mandatory usage of Web services. A study conducted in mandatory settings, in which students are bound to use Web services, may have different results.

Originality/value

This is the first attempt to apply the UTAUT model to investigate the factors affecting student use of Web-based services from the perspective of distance education and the findings prove strong support for the model.
Geographical visualization of research collaborations of library science in China
Authors: Hu Jiming , Huang Ruhua , Wang Yubo
Published: May 2018

Purpose

The purpose of this paper is to visualize the collaboration network among regions in library science (LS) in China. Using various methods and tools of social network analysis and geographical visualization, results were obtained, showing the structure and patterns of research collaborations in topological and geographical views, as well as the geographical distributions of contribution.

Design/methodology/approach

The sample includes all studies published in the top journal in library science in China from 2006 to 2015. First, co-occurrence data representing collaborations among regions was extracted from author affiliations. Second, the topological network of collaboration was generated by applying social network analysis tools and descriptive statistics, network indicators of the collaboration network and research communities were calculated. Third, the topological network was projected into a geographical map with corresponding coordinates and distances using geographical tools. Finally, the topological network maps and the geographical maps were produced for visualization.

Findings

The levels of contribution are very unbalanced between regions, and overall research collaboration is low. Beijing, Hubei and several other areas are central and significant regions in China; other regions are mostly connected with central ones through direct collaborations. Research collaborations in LS research in China are mostly distributed in the east and south of China, being centralized in the “Beijing–Hubei–Shanghai” triangle zone, as well as within the triangle’s extending zones. Finally, there are three distinct research communities that connect closely within themselves and loosely between them. The Beijing community is relatively centralized in geography, while other communities are scattered.

Originality/value

This study applied various methods and tools of social network analysis and geographical mapping analysis to reveal the collaboration structure and patterns among regions in LS research in China. Visualized maps in topological and geographical views help shed new light on research efforts.
Tapping into the wearable device revolution in the work environment: a systematic review
Authors: Khakurel Jayden , Melkas Helinä , Porras Jari
Published: May 2018

Purpose

The purpose of this paper is to expand current knowledge about the recent trend of wearable technology to assess both its potential in the work environment and the challenges concerning the utilisation of wearables in the workplace.

Design/methodology/approach

After establishing exclusion and inclusion criteria, an independent systematic search of the ACM Digital Library, IEEE Xplore, ScienceDirect and Web of Science databases for relevant studies was performed. Out of a total of 359 articles, 34 met the selection criteria.

Findings

This review identifies 23 categories of wearable devices. Further categorisation of the devices based on their utilisation shows they can be used in the work environment for activities including monitoring, augmenting, assisting, delivering and tracking. The review reveals that wearable technology has the potential to increase work efficiency among employees, improve workers’ physical well-being and reduce work-related injuries. However, the review also reveals that technological, social, policy and economic challenges related to the use of wearable devices remain.

Research limitations/implications

Many studies have investigated the benefits of wearable devices for personal use, but information about the use of wearables in the work environment is limited. Further research is required in the fields of technology, social challenges, organisation strategies, policies and economics to enhance the adoption rate of wearable devices in work environments.

Originality/value

Previous studies indicate that occupational stress and injuries are detrimental to employees’ health; this paper analyses the use of wearable devices as an intervention method to monitor or prevent these problems. Introducing a categorisation framework during implementation may help identify which types of device categories are suitable and could be beneficial for specific utilisation purposes, facilitating the adoption of wearable devices in the workplace.
Governance of autonomous universities: case of Thailand
Authors: Jarernsiripornkul Sakchai , Pandey I.M.
Published: May 2018

Purpose

The purpose of this paper is to examine the governance system of autonomous universities in an emerging economy, i.e., Thailand. The authors examine the degree of freedom that Thai autonomous universities enjoy and the process that they follow in instituting their governance system.

Design/methodology/approach

The authors use case study method of research where units of analysis are 16 public autonomous universities. Data are collected directly from the Universities and available documents and through interviews with ten informants from five universities. Data are analysed using the triangulation method before presenting findings.

Findings

The authors find that Thai autonomous universities had different degree of readiness when they were granted autonomy status by the government. According to their Acts, the universities can specify their own governance pattern, leadership recruitment, revenue management, budgeting and personnel management. With the strengthening role and accountability, the university councils have enjoyed wider space of actions in institutional governance. Size and composition of the councils differ. Big and more mature universities tend to have more members and their councils comprise more outside experts than the small ones. Thai autonomous universities’ governance structure is in the pattern of corporate-like structure. Participatory process is applied in the university decision making. Big universities are strategically directed towards being research universities, while small and newly established universities are striving to expand to health science education. In academic governance, there is an academic board which helps the council to handle academic standards and give academic related recommendations. The launch of Education Criteria for Performance Excellence Framework to standardise the country’s higher education system has become controversial and is said to lessen the universities’ degree of academic freedom. In financial autonomy, the study finds that most universities are still dependent on government budget.

Originality/value

This case study depicts the governance system of autonomous universities in Thailand, which is one of the emerging countries. Taken into account that existing literature regarding university governance, especially in the emerging countries is limited, the study, which eventually proposes recommendations for lifting these universities’ governance performance, should be able to contribute fruitful knowledge in the area.
Mining user queries with information extraction methods and linked data
Authors: Chardonnens Anne , Rizza Ettore , Coeckelbergs Mathias , van Hooland Seth
Published: May 2018

Purpose

Advanced usage of web analytics tools allows to capture the content of user queries. Despite their relevant nature, the manual analysis of large volumes of user queries is problematic. The purpose of this paper is to address the problem of named entity recognition in digital library user queries.

Design/methodology/approach

The paper presents a large-scale case study conducted at the Royal Library of Belgium in its online historical newspapers platform BelgicaPress. The object of the study is a data set of 83,854 queries resulting from 29,812 visits over a 12-month period. By making use of information extraction methods, knowledge bases (KBs) and various authority files, this paper presents the possibilities and limits to identify what percentage of end users are looking for person and place names.

Findings

Based on a quantitative assessment, the method can successfully identify the majority of person and place names from user queries. Due to the specific character of user queries and the nature of the KBs used, a limited amount of queries remained too ambiguous to be treated in an automated manner.

Originality/value

This paper demonstrates in an empirical manner how user queries can be extracted from a web analytics tool and how named entities can then be mapped with KBs and authority files, in order to facilitate automated analysis of their content. Methods and tools used are generalisable and can be reused by other collection holders.
Managing stakeholder knowledge for the evaluation of innovation systems in the face of climate change
Authors: Nikas Alexandros , Doukas Haris , Lieu Jenny , Alvarez Tinoco Rocío , Charisopoulos Vasileios , van der Gaast Wytze
Published: May 2018

Purpose

The aim of this paper is to frame the stakeholder-driven system mapping approach in the context of climate change, building on stakeholder knowledge of system boundaries, key elements and interactions within a system and to introduce a decision support tool for managing and visualising this knowledge into insightful system maps with policy implications.

Design/methodology/approach

This methodological framework is based on the concepts of market maps. The process of eliciting and visualising expert knowledge is facilitated by means of a reference implementation in MATLAB, which allows for designing technological innovation systems models in either a structured or a visual format.

Findings

System mapping can contribute to evaluating systems for climate change by capturing knowledge of expert groups with regard to the dynamic interrelations between climate policy strategies and other system components, which may promote or hinder the desired transition to low carbon societies.

Research limitations/implications

This study explores how system mapping addresses gaps in analytical tools and complements the systems of innovation framework. Knowledge elicitation, however, must be facilitated and build upon a structured framework such as technological innovation systems.

Practical implications

This approach can provide policymakers with significant insight into the strengths and weaknesses of current policy frameworks based on tacit knowledge embedded in stakeholders.

Social implications

The developed methodological framework aims to include societal groups in the climate policy-making process by acknowledging stakeholders’ role in developing transition pathways. The system map codifies stakeholder input in a structured and transparent manner.

Originality/value

This is the first study that clearly defines the system mapping approach in the frame of climate policy and introduces the first dedicated software option for researchers and decision makers to use for implementing this methodology.
Integrating supplier knowledge in new product development projects: decoupled and coupled approaches
Authors: Rosell David T. , Lakemond Nicolette , Melander Lisa
Published: May 2018

Purpose

The purpose of this paper is to explore and characterize knowledge integration approaches for integrating external knowledge of suppliers into new product development projects.

Design/methodology/approach

This paper is based on a multiple, in-depth case study of six product development projects at three knowledge-intensive manufacturing firms.

Findings

Firms make purposeful choices to devise knowledge integration approaches when working in collaborative buyer – supplier projects. The knowledge characteristics of the supplier input guide the choice of either coupling knowledge sharing and combining across firms or decoupling knowledge sharing (across firms) and knowledge combining (within firms).

Research limitations/implications

This study relies on a limited number of case studies and considers only one supplier relationship in each project. Further studies could examine the challenge of knowledge integration in buyer – supplier relationships in different contexts, i.e. in relation to innovation complexity and uncertainty.

Practical implications

Managers need to make choices when designing knowledge integration approaches in collaborative product development projects. The use of coupled and decoupled approaches can help balance requirements in terms of joint problem-solving across firms, the efficiency of knowledge integration and the risks of knowledge leakage.

Originality/value

The conceptualization of knowledge integration as knowledge sharing and knowledge combining extends existing perspectives on knowledge integration as either a transfer of knowledge or as revealing the presence of pertinent knowledge without entirely transmitting it. The findings point to the complexity of knowledge integration as a process influenced by knowledge characteristics, perspectives on knowledge, openness of firm boundaries and elements of knowledge sharing and combining.
Black male student teachers: tomorrow’s teachers?
Authors: Maylor Uvanney
Published: May 2018

Purpose

This paper aims to understand the preparation that a group of black male pre-service students received during their course and its impact on their willingness to commit to entering the teaching profession.

Design/methodology/approach

The paper draws on findings from a small-scale qualitative study of black and minority ethnic student teachers’ experiences in one initial teacher education institution.

Findings

The paper raises questions as to whether black pre-service teachers’ experiences of a lack of acceptance in schools during their pre-service training contribute to the under-representation of black male teachers in English schools.

Originality/value

There is limited research on the experiences of black male student teachers. The paper brings new insights and offers reasons for black male student teachers not entering the teaching profession.