bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Air Pollution on the Immune System
Authors: Liu Diana
Published: July 2021

Air pollution has become a serious problem, the pollutant mainly came from industrial and vehicle exhaustion will harm people’s bodies to a different extent, cause lots of diseases like asthma, and cardiovascular disease. The system protects us are also be damaged by pollutant entering the tissue barrier, harm to immune cells and regulate cytokine secretion. This essay is mainly focused on the particulate matter, sulfur dioxide, and nitrogen oxide effect on the immune system from the innate immunity to the acquired immunity, and how the immune system defense.
Effects of Crown Lengthening on Bi, PLI and PD Levels in Patients with Different Periodontal Biotypes
Authors: Bai Lu
Published: July 2021

Objective: To investigate the effect of crown lengthening on patients with different periodontal biological types. Methods: 60 patients with different periodontal biotypes treated in our hospital from May 2017 to February 2019 were retrospectively analyzed. According to the different periodontal biotypes, the above-mentioned patients were further divided into control group (thin fan type, 30 cases) and observation group (thick flat type, 30 cases).The periodontal probing depth (PD), plaque index (PLI), bleeding index (BI) and gingival margin position at 1 week, 1 month, 2 months and 3 months after operation were compared between the two groups. Results: The PD, Bi and PLI values of the two groups after treatment were lower than those before treatment (P<0.05);There was no significant difference in gingival margin position between the two groups after 1 week to 1 month and 1 month to 2 months (P>0.05);After 2 months to 3 months of treatment, the gingival margin distance of the observation group was larger than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Crown lengthening can effectively improve the periodontal indexes of different periodontal biotypes, and the gingival margin of thick and flat type patients moves more toward the crown.
The Treatment of Chinese Herbal Prescription in a 43 Year-old Woman with Sjogren Syndrome: A Case Report
Authors: Luo Yehao , Chen Geer , Xu Donghan , Li Zhihui , Pang Yuzhou , Fang Gang
Published: July 2021

Background: Sjögren syndrome(SS) is a long-term autoimmune disease that affects the body's moisture-producing glands. It can occur independently of other health problems (primary disease) or as a result of another connective tissue disorder(secondary disease). Medication is directed at the person's symptoms. Recently, it is reported that prescription of Chinese medicine has a great effect on SS and reduce adverse drugs reaction, which can provide a more safer treatment to SS. Case presentation: We here report a 43 year-old Chinese patient with continuous immune thrombocytopenia diagnosed as Sjögren syndrome, who was not response to routine medication such as Methylprednisolone and acyclovir. After that, the patient was treated by prescription of Chinese medicine, and the symptoms were improved apparently. We suppose that prescription of Chinese medicine has an unexpected effect on SS, which can alleviate patient’s symptoms. Conclusion: The clinical efficacy of Sjogren syndrome(SS) is effective in the treatment of prescription of Chinese medicine. It can improve patient’s symptoms and reduce adverse drug reactions.
Sphingosine 1-phosphate in inflammation
Authors: Li Lijuan , An Lixia , Li Lifang , Zhao Yongjuan
Published: July 2021

Sphingolipids are formed via the metabolism of sphingomyelin, aconstituent of the plasma membrane, or by denovosynthesis. Enzymatic pathways result in the formation of several different lipid mediators, which are known to have important roles in many cellular processes, including proliferation, apoptosis and migration. Several studies now suggest that these sphingolipid mediators, including ceramide, ceramide 1-phosphate and sphingosine 1-phosphate (S1P), are likely to have an integral role in in?ammation. This can involve, for example, activation of pro-in?ammatory transcription factors in different cell types and induction of cyclooxygenase-2, leading to production of pro-in?ammatory prostaglandins. The mode of action of each sphingolipid is different. Increased ceramide production leads to the formation of ceramide-rich areas of the membrane, which may assemble signalling complexes, whereas S1P acts via high-af?nity G-protein-coupled S1P receptors on the plasma membrane. Recent studies have demonstrated that in vitro effects of sphingolipids on in?ammation can translate into in vivo models. This review will highlight the areas of research where sphingolipids are involved in in?ammation and the mechanisms of action of each mediator. In addition, the therapeutic potential of drugs that alter sphingolipid actions will be examined with reference to disease states, such as asthma and in?ammatory bowel disease, which involve important in?ammatory components. A signi?cant body of research now indicates that sphingolipids are intimately involved in the in?ammatory process and recent studies have demonstrated that these lipids, together with associated enzymes and receptors, can provide effective drug targets for the treatment of pathological in?ammation.
Brief Introduction to the Contribution of "Zhouhou Beijifang" to the Emergency Treatment in Traditional Chinese Medicine
Authors: Yao Lan , Li Yajun
Published: July 2021

As the first emergency treatment handbook in China, "Zhouhou Beijifang" recorded a large number of treatment methods used in attending to emergencies, and is known for its simplicity, convenience, low-cost and experience. This paper discusses the important value of moxibustion, nasal drug therapy, sublingual administration, emergency surgery and excretion-based drugs in the treatment of emergencies in the book, and discusses its significance and contribution to modern medicine in the history of emergency treatment.
Exploring the Influences of Continuous Self-Management Education on the Self-Care Skills and Health Behavior of Patients with PICC Intubation
Authors: Zhang Xinrui , Huang Huiying , Yang Chunyan , Du Yanfang , Wang Xinxin , Zhang Juan
Published: July 2021

Objective: To analyze the effects of continuous self-management education on the self-care ability and health behavior of patients with tumor through peripherally inserted central venous catheters (PICC). Methods: The period from August 2018 to August 2020 was used as the research time range, and the random number table method was used as the basis for grouping. 80 patients with malignant tumors who regularly performed fixed catheter maintenance care in the PICC clinic of our hospital were admitted in the experimental group (given PICC specialist nursing, and implemented continuous self-management education), and 80 patients with PICC tube malignant tumors discharged from the superior hospital during this time range served as the control group (return to the original catheterization hospital from time to time or perform catheter maintenance care in the nursing clinic of our hospital). The self-care ability scores, health behavior scores, and complications during intubation between both groups were analyzed. Results: (1) There was no significant difference in self-care ability score and healthy behavior score between groups before the intervention, P>0.05; the self-care ability score and health behavior score of the research group were better than the control group after intervention, P<0.05; (2) After investigation, the incidence of complications in the research group (2.50%) was lower than that of the control group (10.00%), but there was no difference between the groups, P>0.05. Conclusion: Continuous self-management education has good effects on improving the self-care ability of tumor patients with PICC intubation. It can urge patients to maintain good health behaviors and reduce complications. It is worthy of promotion.
Research of the Clinical Effect of Kyphoplasty in the Treatment of Multiple Senile Osteoporotic Spinal Fractures
Authors: Liu Tianhui , Cui Jianmin
Published: July 2021

Objective: To evaluate the clinical effect of kyphoplasty in the treatment of multiple osteoporotic vertebral fractures in the elderly. Methods: The duration of the study was selected from January 2018 to December 2020, and 38 patients with multiple osteoporotic spinal fractures were selected for study evaluation. All patients were treated with kyphoplasty. The clinical indicators of the two groups were compared and analyzed. Results: The total effective rate was 94.7% and the complication rate was 5.3%. The height of midline, anterior and posterior vertebral body, Cobb angle, VAS score, ODI score and ADL score of 38 patients before and after treatment were compared, which were significantly better than those before treatment (P<0.05). Conclusion: The clinical effect of kyphoplasty in the treatment of elderly patients with multiple osteoporosis is significant, which can be promoted in all levels of medical institutions.
Clinical Study on the Effects of Electroacupuncture Combined with Extracorporeal Shock Wave in the Treatment of Periarthritis of Shoulder
Authors: Qi Peng , Zhang Yu , Li Shengguang , Yu Hongjian
Published: July 2021

Abstract: Objective: To investigate the clinical effects of electroacupuncture combined with extracorporeal shock wave in the treatment of periarthritis of shoulder. Methods: 136 patients with periarthritis of shoulder admitted to our hospital from September 2018 to September 2019 were randomly divided into two groups by double-blind method. 68 patients in the control group were treated with extracorporeal shock wave; 68 patients in the observation group were treated with electroacupuncture combined with extracorporeal shock wave. The shoulder joint pain, joint function and activities of daily living were compared between the two groups. Results: The VAS score of shoulder joint pain in the observation group after treatment (1.92±0.24) was lower than that in the control group (3.51±0.32), and the UCLA score of shoulder joint function (31.28±1.96) was higher than that of the control group (27.42±2.36), the differences were statistically significant (P<0.05). After treatment, the active degree of forward flexion and extension of shoulder joint in the observation group was higher than those of the control group, and the activities of daily living was higher than that of the control group, with statistically significant differences (P<0.05) Conclusion: Electroacupuncture combined with extracorporeal shock wave treatment for periarthritis of shoulder has achieved ideal effects, safety and non-invasiveness, and can quickly restore the functions of shoulder joints.
Efficacy of Metoprolol Succinate Sustained Release Tablets Combined with Wenxin Granules in the Treatment of Coronary Heart Disease Arrhythmia
Authors: Zhao Guangqing , Yao Liling
Published: July 2021

Objective: To explore the effect of metoprolol succinate sustained-release tablets combined with Wenxin Granules in the treatment of coronary heart disease patients with arrhythmia. Methods: The research objects were 50 patients with arrhythmia who were treated in our hospital from September 2019 to September 2020. According to different treatment methods, they were divided into observation group (Wenxin Granule + metoprolol succinate treatment) and control group (metoprolol succinate treatment), 25 cases in each group. The curative effects of the two groups were compared. Results: After treatment, there was no significant difference in rnn50, RMSSD, sdnni and SDANN between the two groups (P>0.05). Compared with the control group, the SDNN in the observation group was higher than that in the control group (P< 0.05); Before treatment, there was no significant difference in the above indexes between the two groups (P>0.05); The effective rates of the observation group and the control group were 92.00% and 68.00% respectively, and the curative effect of the observation group was higher than that of the control group (P< 0.05); There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: In the treatment of patients with coronary heart disease and arrhythmia, Wenxin Granule Combined with metoprolol succinate sustained-release tablets has significant effect, which can effectively improve the dynamic electrocardiogram indexes of patients, improve the clinical efficacy, and has high safety.
Effect of Expanded Polytetrafluoroethylene Combined with Autologous Ear Cartilage in Nasal Plastic Surgery
Authors: Xie Jinqing , Wang Zhiqiang
Published: July 2021

Objective: To explore the effect of combined application of expanded polytetrafluoroethylene and autologous ear cartilage in nasal plastic surgery. Methods: 76 cases of nasal plastic surgery patients in our hospital from September 2019 to September 2020 were selected as the research objects and divided into experimental group (38 cases, treated with expanded polytetrafluoroethylene + autologous ear cartilage surgery) and control group (38 cases, treated with autologous ear cartilage surgery). The treatment effect, appearance score and complications were compared. Results: The total effective rate of the experimental group (97.37%, 37 / 38) was higher than that of the control group (78.95%, 30 / 38), P< 0.05; After treatment, the appearance score of the experimental group was (8.97 ± 0.37), which was significantly higher than that of the control group (P< 0.05); The total incidence of complications in the experimental group (5.26%, 2 / 38) was significantly lower than that in the control group (21.05%, 8 / 38), P< 0.05. Conclusion: In the process of nasal plastic surgery, the combined application of autologous ear cartilage surgery and expanded polytetrafluoroethylene has obvious effect, improves the appearance of patients, and has less postoperative complications, which is worthy of promotion.
Understanding the Mechanism of Sun Simiao's Treatment of Stroke from the Perspective of the Divergence of Pungent Medicine
Authors: Chen Yao , Zhang Xiaoke , Zhang Huan
Published: July 2021

In ancient times, the application of Xuming Decoction was popular in the treatment of stroke. Sun Simiao was a famous physician in treating stroke disease in his times. He inherited the theme of Xuming Decoction for treating wind with pungent herbs. This paper focuses on reviewing Sun Simiao’s application of Xuming Decoction in “Qianjin Yaofang”, we re-apprehend the mechanism of Sun Simiao's treatment of stroke from the perspective of the divergence of pungent medicine.
On the Academic Value and Influence of Wang Hao-gu’s ‘Yinzheng Lueli’
Authors: Zhang Zhiguan , Wei Yonghong , Yu Kehui , Li Yajun
Published: July 2021

The magnum opus of the famous physician Wang Haogu in the Yuan Dynasty, "Yinzheng Lueli (Brief Examples of Yin Syndromes)", invented the "Yin Syndrome" theory based on "The Treatise on Febrile Diseases", systematically discussed the theory of "cold drinking leads to internal injury", and advocated the treatment of warm tonifying the spleen and kidney rather than heat tonification, initiated the study of "warm tonification" in the subsequent Ming and Qing Dynasties. These have played an important role in the inheritance and advancement of the Yishui School, and also have a profound impact on the Chinese medicine theory and the diagnosis and treatment of diseases in later generations.
Research Progress of miRNA Regulating Cell Signaling Pathways Related to Hepatocarcinogenesis
Authors: Wang Dan , Yang Xingwu , Wang Guotai
Published: July 2021

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in clinical practice. The pathogenesis of HCC is still unclear. Currently, the clinical treatment of HCC is poorly targeted and the therapeutic effect is poor. MicroRNAs (miRNAs) are closely related to the occurrence of HCC, and they are mainly involved in the occurrence and development of HCC through binding to target genes or acting on related signaling pathways. In recent years, studies have shown that miRNA can be used as a potential biomarker for diagnosis and prognosis of HCC. In addition, studies have also shown that miRNA plays a tumor-suppressing or tumor-promoting role in the process of HCC by regulating the biological processes of tumor cell proliferation, migration, invasion and metastasis. In this paper, the recent studies on miRNA signaling pathways related to the occurrence and development of HCC were reviewed, with a view to providing ideas for the clinical diagnosis and treatment of HCC.
Clinical Experience of Professor Du Xiaoquan's Treatment of Spleen and Spleen Disease
Authors: Pang Chenhuan , Du Xiaoquan
Published: July 2021

Professor Du Xiaoquan is a famous Chinese medicine in Shaanxi Province, a master's tutor, a professor of Shaanxi University of traditional Chinese Medicine, a director of the Department of traditional Chinese Medicine, and a professor of Shen Shuwen, a national famous old Chinese medicine.
Photodynamic Therapy for Advanced Gastric Cancer: A Case Report
Authors: Zhang Hongyan , Wu Lule , Hu Xiaoxiong , Sheng Jianwen , Wu Yuwen , Fan Huizhen
Published: July 2021

Background and Study Aims: To observe the efficacy of photodynamic therapy in patients with advanced gastric cancer and analyze the reasons affecting the efficacy. Methods: In this paper, a patient with advanced gastric cancer in our hospital was selected.HoPorfin is used as a photosensitizer and photodynamic therapy was performed 48 hours and 72 hours later. Results: One month after the photodynamic treatment, the patient came to our hospital to reexamine the gastroscope. Through the comparison of gastroscopy before and after the photodynamic treatment, the gastric cancer lesion of the patient after the photodynamic treatment was not significantly smaller than before, and the effect of photodynamic treatment was not ideal. Conclusion: The four reasons for the unsatisfactory effect: individual differences of patients, photosensitizer, light source and oxygen.
Effect of Metoprolol on Cardiac Function and Prognosis in Patients with Dilated Cardiomyopathy
Authors: Su Huailing , Li Bin , Jia Zhisheng
Published: July 2021

Objective: To investigate the effect of metoprolol on cardiac function and prognosis in patients with dilated cardiomyopathy. Methods: 100 patients with dilated cardiomyopathy treated in our hospital from January 2018 to December 2019 were randomly divided into control group (n = 50) and observation group (n = 50). The control group was treated with conventional methods, and the observation group was treated with conventional methods and metoprolol for 6 months. The cardiac function [left ventricular ejection fraction (LVEF), stroke volume (SV), cardiac output (CO)] and prognosis [Glasgow Outcome Scale (GOS) score] of the two groups before and at the end of 6 months of intervention were compared, and the incidence of adverse reactions of the two groups were compared. Results: After 6 months of treatment, the levels of LVEF, SV and CO in the two groups were higher than before treatment, and the comparison level between the observation group and the control group was higher, the difference was statistically significant (P  < 0.05);After 6 months of treatment, the GOS score of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05);There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion:  Metoprolol can improve the cardiac function and prognosis of patients with dilated cardiomyopathy, without increasing the incidence of adverse reactions.
Study on Prevention and Treatment of Autophagy and Cervical HPV Infection by Traditional Chinese Medicine Based on Pathogenesis of "Syndrome of Dampness-heat Diffusing Downward"
Authors: Liu Anqi , Chen Mei , Li Nan , Zhu Hongli , Bai Jun , Zhao Xin , Yang Jiaxue
Published: July 2021

Autophagy is a self-protection mechanism of the body, and also an important physiological process for cells to maintain internal environment stability. Studies have shown that the degree of autophagy damage is positively correlated with the expression of oncogenes, and the expression of oncogenes is closely related to cervical HPV infection, so the control of autophagy ability can interfere with cervical HPV virus infection. Traditional Chinese medicine believes that dampness-heat evil down, can damage and Chong Ren cell. The author believes that autophagy damage and the theory of dampness-heat injection in cervical HPV infection have similar pathogenic mechanism, and explores the prevention and treatment of autophagy and cervical HPV infection based on the theory of traditional Chinese medicine dampness-heat injection, in attempt to provide a new treatment for clinical prevention and treatment.
Effect of Stereoscopic Comprehensive Therapy of Zhuang Medicine on Inflammatory Factor IL-6 in Patients with Rheumatoid Arthritis
Authors: Tang Xiusong , Chen Yanqiang , Shang Yuzhi , Fu Yulei , Pang Yuzhou
Published: July 2021

Objective: To study the effect of Stereoscopic Comprehensive of Therapy Zhuang Medicine on IL-6 in serum of patients with rheumatoid arthritis. Methods: Sixty rheumatoid arthritis patients who met the inclusion criteria were selected and randomly divided into a control group and a treatment group using a random number table. Among them, 30 cases in the control group were treated with Western medicine, and 30 cases in the treatment group were treated with Western medical and Stereoscopic Comprehensive Therapy of Zhuang Medicine. The observation period was 8 weeks. Results: After 8 weeks of treatment, the level of IL-6 in the treatment group and the control group decreased, and the treatment group was better than the control group (P<0.05). Conclusion: The Stereoscopic Comprehensive of Zhuang Medicine can reduce the level of IL-6 in the serum of patients with rheumatoid arthritis, and has a good regulating effect on the inflammation of rheumatoid arthritis.
Effect Observation of Clinical Treatment with Oxaliplatin and Tiggio for Biliary Tract Tumors on Advanced Stage
Authors: Zheng Wei , Wang Haibin , Zhou Jiao
Published: July 2021

Objective: To investigate the effect of oxaliplatin combined with tiggio in the treatment of advanced biliary tract tumors. Methods: The research period was from November 2019 to November 2020. 80 patients with advanced biliary tumor disease were enrolled. They were divided into groups according to the order of admission, with 40 cases in each group. The control group received oxaliplatin combined with gemcitabine, and the experimental group received oxaliplatin combined with tiggio. Incidence of adverse reactions, time to disease progression, survival time and clinical efficacy were checked and assessed. Results: Compared with the incidence of adverse reaction of the experimental group, which was 5.00% (2/40), the incidence of adverse reaction of the control group was 25.00% (10/40). The chi-square value = 6.2745, p-value = 0.0122. The time to progression and survival time of patients in the experimental group were shorter than those of the control group, with significant differences between the groups (p<0.05); the clinical efficacy of the experimental group and the control group were 97.50% (39/40) and 77.50% (31/ 40) respectively, the comparative chi-square value = 7.3143, p-value = 0.0068. Conclusion: The combined treatment of oxaliplatin and Tiggio in the treatment of advanced biliary tract tumors has higher safety and reduces the incidence of adverse reactions.
Clinical Study on Treatment to Ankylosing Spondylitis with Fengshi Qutong Capsule-Diclofenac Sodium Combination
Authors: Wang Haibin , Wang Ying , Tian Xin , Liu Shizhang , Ji Le
Published: July 2021

Objective: To discuss the clinical study on Fengshi Qutong capsules combined with diclofenac sodium in the treatment of ankylosing spondylitis. Methods: 80 patients who were treated for ankylosing spondylitis from June 2019 to June 2020 were selected and divided into two groups. The experimental group was treated with Fengshi Qutong capsules combined with diclofenac sodium, and the control group was treated with sulfasalazine enteric-coated tablets. Results: The treatment efficacy, VAS score, BASDAI score, BASFI score, CRP level, TNF-? level, IL-I? level, and the incidence of adverse reactions between the two groups were significantly different (P<0.05). Conclusion: The application of Fengshi Qutong capsules combined with diclofenac sodium in the treatment of patients with ankylosing spondylitis is beneficial to improve the treatment efficacy, reduce the levels of CRP, TNF-?, and IL-I?, reduce the incidence of adverse reactions, and reduce the VAS, BASDAI and BASFI scores, rendering it of important clinical value.
Observation on the Clinical Effect of Modified Circumcision in the Treatment of Phimosis and Excessive Foreskin
Authors: Ju Jiechang
Published: July 2021

Objective: To study the clinical effect of modified circumcision in the treatment of phimosis and excessive foreskin. Methods: 110 patients with overly long foreskin or phimosis were divided into experimental group and control group by random number table method, with 55 cases in each group. The experimental group was treated with modified circumcision, and the control group was treated with traditional manual cutting and suture. Then the clinical effects of the two treatments were compared. Results: Two different surgical procedures were performed. During the operation, the blood loss of the experimental group was less than that of the control group; the operation time and wound healing time were shorter than those of the control group; after the operation, the incidence of related complications in the experimental group was 14.55%, which was significantly lower than For 25.45% of the control group, the clinical treatment effect was obvious, and the difference was statistically significant (P<0.05). Conclusion: The clinical effect of modified circumcision in the treatment of patients with phimosis and excessive foreskin is good. Compared with the traditional manual cutting and suture treatment, it not only has the advantages of simple operation and clinical application, but also benefits the rehabilitation of patients. Rehabilitation time reduces the incidence of postoperative complications. It is an ideal treatment plan for this type of disease in the current clinic, and it is worthy of popularization and application in general surgery and reproductive surgery.
Research Progress on Inducible Nitric Oxide Synthase in the Pathogenesis of Pancreatic Malignancy
Authors: Xiong Huimin , Wang Ruiyao , Zhang Chao
Published: July 2021

Pancreatic cancer is a common tumor of the digestive system. At present, the pathogenesis is still unclear, but current research on inducible nitric oxide synthase in relation to the pathogenesis of pancreatic malignant tumors is particularly extensive. Therefore, this article focuses on the research progress on inducible nitric oxide synthase in the pathogenesis of pancreatic cancer.
Clinical Study of Recombinant Human Endostatin Combined with Iressa in Targeted Treatment of Patients with Lung Adenocarcinoma with Pleural Metastasis
Authors: Wang Yanbing
Published: July 2021

Objective: To evaluate and comprehensively analyze the clinical efficacy of recombinant human endostatin combined with Iressa targeted therapy in patients with pleural metastasis of lung adenocarcinoma. Methods: The interval of the selected study period span was from January 2017 to April 2021. The sample source of the study was 42 patients with lung adenocarcinoma admitted to hospital. The random number table method was used for study grouping, and they were further divided into study groups (n = 21, 14 cases with pleural metastasis) and control group (n=21, 13 cases with pleural metastasis), all patients received systemic chemotherapy with pemetrexed and cisplatin. Patients with pleural metastases in the control group were injected with 60 mg cisplatin into the thoracic cavity. Patients in the study group were treated with Iressa (gefitinib) targeted therapy if genetic testing showed epidermal growth factor receptor (EGRF) mutations, and patients with pleural metastases were treated with pleural metastasis with Endo (recombinant human endostatin YH-16) to control pleural effusion. Two sets of related indicators were compared and analyzed. Results: Comparing the short-term disease control rate, treatment effectiveness and long-term survival rate between the two groups shows that the study group has more advantages (P<0.05). In the comparison between the two groups of serum markers and related indicators, the study group has more advantages (P<0.05), whereas in the comparison between the two groups in the incidence of adverse reactions, there is no significant difference (P>0.05). Based on statistics of the recurrence rate of pleural fluid in the two groups, the study group is significantly lower than the control group (P<0.05). Conclusion: Recombinant human endostatin combined with Iressa targeted therapy for patients with lung adenocarcinoma with pleural metastasis has significant short-term and long-term effects without serious adverse reactions. It can be fully promoted in medical institutions at all levels.
A Study on the Determination of Azithromycin by High-Performance Liquid Chromatography
Authors: Zhuo Yanli
Published: July 2021

Objective: To analyze the effect of high-performance liquid chromatography (HPLC) for the determination of azithromycin and to provide references for related research work. Methods: The mobile phase was ammonium dihydrogen phosphate at 0.067 mol/L (mixed with triethylamine; pH value was adjusted to 6.5). The chromatographic column was Kromasil C18 (250 mm × 4.6 mm; 5.0 ?m) and the relative standard deviation (RSD) of the drug content level was 1.25%. The injection volume was set to 20 ?L, the detection wavelength was set to 210 nm, the external standard method was used to complete the quantitative work, and the theoretical plate number should be more than 1000 according to the drug peak calculation. The effect of HPLC on the determination of azithromycin was analyzed. Results: The concentration of azithromycin was 1.40-3.40 mg/mL, and the linear relationship was good. RSD of the drug content level was 1.25%. The representative test product had strong stability within 8.0 hours and the method had good repeatability. According to the recovery experiment method, the recovery rates of three standard samples from low to high were 99.87%, 100.15%, and 100.62%. The average recovery rate was 100.21%. RSD value was 0.39%. It means that the recovery rate of HPLC is good. Conclusion: In the determination of azithromycin, the use of HPLC to complete the work was of high sensitivity, simple, and fast. The method had good repeatability in the determination of drug components which is worthy of further promotion.
Credit scoring e a proteção de dados pessoais
Authors: Peres Marilia De Moraes , Simão Filho Adalberto
Published: July 2021

O avanço da tecnologia propiciou o uso de métodos de tratamento de dados, incorporando, no dia a dia de determinadas empresas, filtros que permitem minuciar o usuário. Mas essa utilização indiscriminada vem sendo limitada em vários países do globo, fazendo com que o emprego do tratamento de dados seja adequado às recentes normas. No Brasil, foi sancionada a Lei nº 13.709, em 14 de agosto de 2018 (LGPD), que entrará em vigência em dezembro de 2020, obrigando as companhias nacionais a fazer os devidos ajustes conforme as exigências legais. As instituições financeiras, normalmente, utilizam o procedimento do credit scoring para auferir pontuação adequada a cada perfil de solicitante de crédito, sendo que esse sistema requer o emprego de dados. Com a implantação da nova legislação, haverá um impacto sobre o setor do crédito. Todavia, este impacto será diminuto, porém essencial tanto para a liberdade individual quanto para a saúde econômica do país.
A livre iniciativa como fator de desenvolvimento na ordem econômica
Authors: Monaco Rafael Oliveira , Da Silva Rogerio Borba
Published: July 2021

O presente artigo tem por objeto tratar da livre iniciativa como fator de desenvolvimento na Ordem Econômica. Para o alcance do objetivo a pesquisa iniciou pelos aspectos gerais relativos à constitucionalização da Economia plasmada em uma Ordem Constitucional Econômica. Em seguida se tratou dos sistemas econômicos de produção até à consagração da livre iniciativa em toda a sua envergadura. Logo depois, se verificou a evolução legislativa da livre iniciativa, no Direito Brasileiro, com a explanação de seu conceito e natureza jurídica. Após se demonstrou que o alcance do Desenvolvimento perpassa pela ideia de plena liberdade indo além do mero crescimento econômico. Para o alcance do escopo, a pesquisa buscou realizar uma revisão bibliográfica sobre o tema, bem como se valeu de uma metodologia quantitativa, por meio de dados estatísticos extraídos de fontes oficiais. A pesquisa converge para a demonstração de que a liberdade econômica é essencial para alcance do Desenvolvimento de um país devendo ser empreendido esforços para o resgate da informalidade constituindo dever do Estado a criação de instrumentos que estimulem a iniciativa empreendedora e que garantam o fluxo e a segurança jurídica das transações.
A aplicação de tecnologias limpas para o desenvolvimento urbano sustentável através da implantação de energia fotovoltaica
Authors: Oliveira Bruno Bastos de , Cunha Belinda Pereira da , Martins Solange
Published: July 2021

O ser humano busca atender os seus desejos e as suas necessidades através da aquisição de bens e produtos ofertados pelas empresas. Existe assim estabelecido uma relação que caracteriza a função social da empresa: ofertar mercadorias, produtos e serviços visando atender os clientes, criando emprego, contribuindo para a arrecadação de receitas para o estado e movimentando a economia.  Não basta pensar em lucratividade, é preciso inovar. Assim, surgem as startups, como instrumento para criação de empreendimentos inovadores. O surgimento de oportunidades de inovação voltada ao desenvolvimento sustentável, quando estas startups investem no mercado de geração de energia fotovoltaica, colaborando e disseminando nas zonas urbanas, em empresas ou residências, uma provável economia de energia elétrica, divulgando assim a adoção de painéis solares que transformam a energia solar em energia fotovoltaica. O objetivo deste artigo é apresentar as possibilidades da aplicação de tecnologias limpas, também denominadas “Cleantechs” aplicáveis no desenvolvimento urbano sustentável através da implantação da energia fotovoltaica. O método utilizado na abordagem da temática foi o método dedutivo, através de pesquisa bibliográfica em obras de renomados autores Aliado ao crescimento urbano e a preocupação com o ecossistema, há possibilidade de verificar os instrumentos legais relacionados a proteção do meio ambiente, ao desenvolvimento sustentável e a qualidade de vida da população atual e das futuras gerações.
O custo dos direitos fundamentais e a fonte de custeio para a implementação de políticas públicas no Brasil
Authors: Rezende Heverton Lopes , Ribeiro Maria de Fátima
Published: July 2021

A dignidade da pessoa humana consagra a ideia de proteção homogênea aos seres humanos, mormente em relação ao “mínimo existencial”, ou seja, as condições básicas para uma vida digna. Esse seria o limite mínimo da tributação: uma espécie de barreira que não deve ser violada pelo Estado, pois representa literalmente a salvaguarda das condições mínimas para sobrevivência. Outrossim, é certo que todos os direitos tem um custo, o qual é sustentado pelo Poder Público. Para tanto, o objetivo geral deste artigo é estabelecer uma relação entre o dever de pagar o tributo e à fonte de custeio para a implementação de políticas públicas no Brasil. Através do método dedutivo, pesquisa descritiva e bibliográfica foi constatado que o contribuinte tem o dever fundamental de pagar os tributos devidos, pois eles estão diretamente relacionados com a contraprestação do Estado na implementação de serviços públicos e atendimento aos objetivos fundamentais da república, representando a principal fonte de custeio. Entretanto, a tributação não deve ser extremamente onerosa dentro de determinada realidade social, sob pena de ter um efeito confiscatório. Por fim, foram apresentadas duas medidas adotadas pelo Governo durante a pandemia da Covid-19 como medidas de implementação da justiça social e recuperação da economia, a saber: o regime extraordinário fiscal, financeiro e de contratações para enfrentamento de calamidade pública nacional e a ajuda financeira aos Estados e Municípios.
From criminal principiology to the right to intimacy as a constitutional guarantee
Authors: Greco Rogério , Palitot Braga Romulo Rhemo
Published: July 2021

The current text presents an initial reflection on the importance of the Penal Law and its principles, expressed or implicit in a positivistic perspective. They should be understood as informants of all the juridical order with the capacity to ascertain the validity under constitutional class rules, occupying, in this way, a hierarchically superior place. It will also be considered, the bond between Penal Law and the recognition of the principle of the dignity of the human person, especially regarding the right to intimacy. The technique used to the bibliography
Dissociated forms of moraxella isolated from the affected eyes of cattle
Authors: Ivanov N. P. , Sattarova R. S.
Published: July 2021

The dissociation phenomenon of epizootic cultures of Moraxella was studied. The study was conducted in economic entities of Almaty region of the Republic of Kazakhstan for 233 heads of cattle with clinical signs of keratoconjunctivitis. Isolation of the causative agent of Moraxella was performed by bacteriological washes from the conjunctival sacs of the eyes of animals. The laboratory study was carried out according to the approved methodological guidelines. It was found that bacteria of the genus Moraxella dissociate when grown on a solid nutrient medium for more than 6 hours in a thermostat at 37 °C. The bacteria were studied by the following methods: staining according to White-Wilson, thermoagglutination and acriflavine assay. When evaluating the grown colonies according to White-Wilson, the optimal dilution for crystal violet was found to be 1 : 2000, and for gentian violet stain 1 : 1000. In this case, the colonies in the S-form have a dark purple color with a metallic tint, and the dissociated colonies in the R-form do not stain. In the presence of dissociated cells, precipitation (thermoagglutination), sediment formation and clearing of the supernatant fluid at 90 °C for 30 minutes were noted. The suspension of undissociated colonies remained cloudy. When weighing microbial cells isolated by a bacterial loop from individual grown colonies in a solution of acriflavine, dissociated bacteria stick together to form conglomerates. When studying the antigenic activity of the S-, R- forms of Moraxella, it was revealed that the activity of the S-antigen significantly exceeded that of the R-forms. Data on the dissociation of Moraxella cultures can be used for the development of diagnostic and prophylactic drugs against moraxellosis in cattle.
Productivity of garden strawberry and breeding possibilities to improve it
Authors: Marchenko L. A.
Published: July 2021

The information on the productivity trait of garden strawberry Fragaria × ananassa (Duchesne ex Weston) Duchesne ex Rozier has been summarized on the basis of literary sources. The productivity trait has a complex polygenic character. Independent inheritance of individual productivity components allows modeling their optimal combination in a new variety. The creation of highly productive varieties of strawberries is based on intraspecific hybridization. The established positive correlation between the size of berries and the yield indicates the possibility of increasing the productivity of varieties by using large-fruited forms in breeding. At present, in various zones of horticulture, researchers distinguish large-fruited varieties of domestic breeding: ‘Atlas', ‘Bereginya', ‘Vityaz', ‘Grenada', ‘Zabelinskaya', ‘Kemiya', ‘Nashe Podmoscovie', ‘Nelly', ‘Pervoklassnitsa', ‘Rusich', ‘Solnechnaya Polyanka', ‘Solovushka', ‘Festivalnaya Romashka', ‘Fruktovaya', ‘Tsaritsa', ‘Yaponka', and foreign breeding: ‘Alba', ‘Asia', ‘Elsanta', ‘Finesse', ‘Florense', ‘Vivaldi', ‘Galia', ‘Jive', ‘Joly', ‘M. Champion', ‘Merced', ‘Murano', ‘Onda', ‘Roxana', ‘Rumba', ‘Tarda Vicoda', ‘Vima Kimberly', ‘Vima Tarda', ‘Vima Rina', ‘Vima Xima'. It was noted that when using the inbreeding method, it is possible to achieve a heterotic effect on the basis of the productivity trait. The method of genetic modifications of plants is of great importance for breeding of complex quantitative traits of productivity, including yield. Expansion of the genetic base of garden strawberry by means of octoploid and polyploid forms of wild species will ensure an increase in the productivity of new varieties due to the inclusion of traits of adaptability to biotic and abiotic factors in the genotype. The use of modern research methods (screening of the metabolomic and biochemical profile, DNA certification, molecular labeling) increases the objectivity of research and the efficiency of the breeding process.
Effect of silver nanoparticles on bactericidal activity and antibiotic sensitivity of Salmonella enteritidis182
Authors: Shkil N. N. , Nefedova E. V.
Published: July 2021

Studies have been carried out to determine the synergetic effect of the use of combinations of antibacterial substances, including antibiotics, septabic disinfectant and AgNPs. A significant increase in bactericidal activity was revealed in the combination of septabic + AgNPs + nitox and septabic + AgNPs + ceftiofur. Determination of the sensitivity of Salmonella enteritidis 182 to antibacterial drugs showed the presence of resistance to 8 drugs (38.1%), low sensitivity to 7 (33.3%), sensitivity to 6 (28.6%) and the absence of preparations with high sensitivity indicators. After cultivation of S. enteritidis 182 with antibacterial drugs and their combinations, an increase in the number of preparations to which the studied strain was sensitive was found. The presence of sensitivity to 7-10 drugs was revealed, which is 4.7-19.6% higher than in the control indicators. A previously absent high sensitivity to 2-8 antibacterial drugs (9.5-38.0%) was established. The cultivation of S. enteritidis 182 with AgNPs showed the highest increase in antibiotic sensitivity of all the studied combinations of antibacterial agents in the form of the growth inhibition size increase. This suggests a leading role of AgNPs in overcoming antibiotic resistance. Incubation of S. enteritidis 182 after contact with septabic and argovite caused a maximum increase in the diameter of the growth inhibition of the microorganism without decreasing sensitivity to certain types of drugs (with the exception of septabic, where the loss of sensitivity to tylosin was established). When adding various antibiotics to the combination of septabic + argovit, a decrease in the growth inhibition zone or its disappearance were noted. The combined effect of the use of antibacterial drugs together with silver nanoparticles against bacteria with multidrug resistance is described.
ELECTROCHEMICAL PREPARATION OF A MOLECULAR IMPRINTED POLYMER ELECTRODE FOR ESTEMATION OF ASPIRIN USING TWO DIFFERENT FUNCTIONAL MONOMERS.
Authors:   1Assistant Lecturer, Pharmacy Department, Al-Rasheed College University, Iraq. aseel_mansoor@ymail.com, S. Mansoor1 Aseel
Published: July 2021

For aspirin estimated, a molecularly imprinted polymer MIP-ASP electrodes were generated by electro-polymerization process, the electrodes were prepared by combining the template (aspirin) with (vinyl acetate (VA), 1-vinylimidizole (VIZ) as a functional monomer and N, N-methylene bisacrylamide (MBAA) as crosslinkers using benzoyl peroxide (BPO) as an initiator. The efficiency of the membrane electrodes was analyzed by differential pulse voltammetry (DPV). Four electrodes were synthesized using two different plasticizers, di-butyl sebacate (DBS), di-octyl phthalate (DOP) in PVC matrix. Scanning electron microscopy (SEM) was used to describe the generated MIP, studying the electrodes properties, the slope, detection limit, and life time and linearity range. The effect of PH and interferes on the efficiency of the MIP electrode was investigated. The study has shown that the molecularly imprinted electrodes have high sensitivity and responsiveness to aspirin. The DPV value was linearly dependence on the aspirin concentration and a linear curve was obtained within the range of (1×10−1-5×10-4) M of aspirin with correlation coefficients are about (0.9974, 0.9966, 0.9938 and 0.9961) with slops value of (-21.41, -17.67, -17.47 and -18.67) and the detection limit for all electrodes ranging from (7.5×10-5-1×10-4) M. The molecularly imprinted electrode exhibited a good response with highly reproducible and no effect on interferes frequently available in pharmaceutical formulations. The approach employed is easy and fast. Also ASP membranes get a limited time of response, excellent mechanical stability, removable and are easy to construct.
BANKING COMPLIANCE FUNCTION(COMPARATIVE STUDY BETWEEN COMMERCIAL & ISLAMIC BANKS)
Authors:   1Prof. PhD., Business Administration College of Business Economies, Al Nahrain University. Baghdad. Iraq. naghamalnama@gmail.com, H. Neama1 Nagham
Published: July 2021

Never the less, banking compliance function became one of the most important functions in banking sector according to its characteristics that considered as an interior control tools to control (executive management, departments, subsidiaries…etc) in any bank; and their compliance towards applying rules, recommendations and legislations. In addition to, estimating the risks and limited them; and controlling the anti-money laundering. Thus, these functions that covered the main concept of (Banking Compliance) would avoid the bank to be under the control of any sanctions.
THE ROLE OF SATELLITE CHANNELS IN FORMING TRAFFIC AWARENESS AND PREVENTING ACCIDENTS - A FIELD STUDY
Authors:   Lecturer PhD., Department of Research and Studies, Market Research & Consumer Protection Center, University of Baghdad, Baghdad, Iraq. dr.afnan@mracpc.uobaghdad.edu.iq, M. Shaban Afnan
Published: July 2021

The importance of the research comes from dealing with the problem of lack of traffic awareness, which causes accidents and the occurrence of human and material losses, and the research aims to study the role of satellite channels in forming traffic awareness among the public, and a sample was chosen from Baghdad consisting of (280) individuals, male and female, and used the questionnaire tool. To obtain the data, which included several questions, the results were analyzed statistically and several results were reached, the most important of which is that there is an interest among the public in following traffic programs at a rate of one to two hours to receive information through traffic programs and to identify and apply general rules, and it was found that there is a statistically significant correlation between the extent of follow-up. The sample is for traffic programs and the extent to which satellite channels spread traffic awareness among individuals, and there is a significant correlation between the sample's intensity of watching traffic programs and the level of obtaining information about traffic awareness from television, and there are differences between the sample averages towards the role of satellite channels in spreading traffic awareness