bluuebunny/crossref_metadata_2025 huggingface dataset:
Complete Chloroplast Genome of Cnidium monnieri (Apiaceae) and Comparisons with Other Tribe Selineae Species
Authors: Ren Ting , Aou Xueyimu , Tian Rongming , Li Zhenbing , Peng Chang , He Xingjin
Published: April 2022

Cnidium monnieri is an economically important traditional Chinese medicinal plant. In this study, the complete chloroplast (cp) genome of C. monnieri was determined using the Illumina paired-end sequencing, the GetOrganelle de novo assembly strategy, as well as the GeSeq annotation method. Our results showed that the cp genome was 147,371 bp in length with 37.4% GC content and included a large single-copy region (94,361 bp) and a small single-copy region (17,552 bp) separated by a pair of inverted repeat regions (17,729 bp). A total of 129 genes were contained in the cp genome, including 85 protein-coding genes, 36 tRNA genes, and eight rRNA genes. We also investigated codon usage, RNA editing, repeat sequences, simple sequence repeats (SSRs), IR boundaries, and pairwise Ka/Ks ratios. Four hypervariable regions (trnD-trnY-trnE-trnT, ycf2, ndhF-rpl32-trnL, and ycf1) were identified as candidate molecular markers for species authentication. The phylogenetic analyses supported non-monophyly of Cnidium and C. monnieri located in tribe Selineae based on the cp genome sequences and internal transcribed spacer (ITS) sequences. The incongruence of the phylogenetic position of C. monnieri between ITS and cpDNA phylogenies suggested that C. monnieri might have experienced complex evolutions with hybrid and incomplete lineage sorting. All in all, the results presented herein will provide plentiful chloroplast genomic resources for studies of the taxonomy, phylogeny, and species authentication of C. monnieri. Our study is also conducive to elucidating the phylogenetic relationships and taxonomic position of Cnidium.
Detecting Proximal Caries on Periapical Radiographs Using Convolutional Neural Networks with Different Training Strategies on Small Datasets
Authors: Lin Xiujiao , Hong Dengwei , Zhang Dong , Huang Mingyi , Yu Hao
Published: April 2022

The present study aimed to evaluate the performance of convolutional neural networks (CNNs) that were trained with small datasets using different strategies in the detection of proximal caries at different levels of severity on periapical radiographs. Small datasets containing 800 periapical radiographs were randomly categorized into a training and validation dataset (n = 600) and a test dataset (n = 200). A pretrained Cifar-10Net CNN was used in the present study. Different training strategies were used to train the CNN model independently; these strategies were defined as image recognition (IR), edge extraction (EE), and image segmentation (IS). Different metrics, such as sensitivity and area under the receiver operating characteristic curve (AUC), for the trained CNN and human observers were analysed to evaluate the performance in detecting proximal caries. IR, EE, and IS recognition modes and human eyes achieved AUCs of 0.805, 0.860, 0.549, and 0.767, respectively, with the EE recognition mode having the highest values (p all < 0.05). The EE recognition mode was significantly more sensitive in detecting both enamel and dentin caries than human eyes (p all < 0.05). The CNN trained with the EE strategy, the best performer in the present study, showed potential utility in detecting proximal caries on periapical radiographs when using small datasets.
Advances in Electrochemical Energy Storage Systems
Authors: Zhang Qi , Pei Wenhui , Liu Xudong
Published: April 2022

The large-scale development of new energy and energy storage systems is a key way to ensure energy security and solve the environmental crisis, as well as a key way to achieve the goal of “carbon peaking and carbon neutrality” [...]
Motor Dynamic Loading and Comprehensive Test System Based on FPGA and MCU
Authors: Zhu Chunxiang , Bao Linxin , Zheng Bowen , Qian Jiacheng , Cai Yongdong , Wang Binrui
Published: April 2022

In view of the problem that the traditional motor test system cannot directly test the transient parameters of the motor and the dynamic arbitrary load loading requirements during motor loading, as well as the high cost of implementation, this research uses STM32+FPGA as the core to form the main control of the motor test system unit, combining the superior control performance of the ARM processor and the high-speed data processing advantages of FPGA. FPGA and STM32 are controlled by the FSMC bus communication and data ping-pong algorithm. Using this method, a small-size control core board in the motor test system is manufactured. It can be embedded in the existing traditional dynamometer system to improve the dynamometer transient parameter test and the dynamic motor loading performance. The experimental results show that the system can basically meet the requirements of the motor transient test and dynamic loading, and can achieve the fastest data refresh rate of 1 ms when measuring the motor’s speed and torque, as well as arbitrary waveform loading within a 100 M sampling frequency, with a loading error of 0.8%. It satisfies the motor transient test and dynamic loading requirements.
Predictive Maintenance System for Wafer Transport Robot Using K-Means Algorithm and Neural Network Model
Authors: Yoo Ji-Hyun , Park Young-Kook , Han Seung-Soo
Published: April 2022

Maintenance is the technology of continuously monitoring the conditions of equipment and predicting the timing of maintenance for equipment. Particularly in the field of semiconductor manufacturing, where processes are automated, various methods are being tried to minimize the economic losses and maintenance costs caused by equipment failure. A new Predictive Maintenance (PdM) technique, a new method of maintenance, is introduced in this paper to develop an algorithm for predicting the failure of wafer transfer robots in advance. The acceleration sensor data used in the experiment were obtained by installing a sensor onto the wafer transfer robot. To analyze these data, the data preprocessing and FFT process were performed. These data were divided into normal data, first error data, second error data, and third error data (failure data) in stages. By clustering the data using the K-means algorithm, the center point distribution of the clusters was analyzed, and the features of the error data and normal data were extracted. Using these features, an artificial neural network model was designed to predict the point of failure of the robot. Previous research on maintenance systems of the transfer robot used fewer than 50 error data, but 1686 error data were used in this experiment. The reliability of the model is improved by randomly selecting data from a total of 2248 data sets. In addition, it was confirmed that it was possible to classify normal data and error data with an accuracy of 97% and to predict equipment failure by applying neural network modeling.
The Impact of Energy Commodity Prices on Selected Clean Energy Metal Prices
Authors: Mróz Maciej
Published: April 2022

The United Nations Framework Convention on Climate Change Paris Agreement has been announced as a crucial step towards combating the global threat of climate change. In the light of ambitious plans for further renewable energy sources development, high demand for nonenergy materials critical for RES is greatly expected. In conclusion, future energy security will be surely based on nonenergy commodities critical for them. As this article directly relates to issues related to new technologies and energy security in new form, the main purpose of this study is to examine the impact of energy commodity prices, namely crude oil, natural gas and coal prices on selected metal prices such as aluminium, chromium, cobalt, copper, lead, nickel, silver, tin, or zinc, both before and over the Paris Agreement period. We are looking for new insights in terms of relationships between traditional fossil fuels and metals used in clean energy technologies potentially established or strengthened shortly after the Paris Agreement was adopted. Currently, the analyses of the impact of institutional conditions such as global agreements (institutional factors) on the emerging or strengthening of relationships between energy and nonenergy resources are very limited. Hence, an autoregressive distributed lag and error correction model are employed.
Recent Advances in Research on Molecular Mechanisms of Fungal Signaling
Authors: Jacob Stefan , Bühring Sri , Bersching Katharina
Published: April 2022

Biochemical signaling is one of the key mechanisms to coordinate a living organism in all aspects of its life. It is still enigmatic how exactly cells and organisms deal with environmental signals and irritations precisely because of the limited number of signaling proteins and a multitude of transitions inside and outside the cell. Many components of signaling pathways are functionally pleiotropic, which means they have several functions. A single stimulus often results in multiple responses, a distinct response can be triggered by numerous stimuli and signals initiated by different stimuli are often transduced via commonly used network components. This review sheds light on the most important molecular mechanisms of cellular signaling in fungi and consequently provides a comprehensive overview about the current state of research on the road to understand the impact of signal transduction in eukaryotic microorganisms.
Meta-Analysis of Effects of Forest Litter on Seedling Establishment
Authors: Wang Zhengning , Wang Dayang , Liu Qingqing , Xing Xianshuang , Liu Bo , Jin Shaofei , Tigabu Mulualem
Published: April 2022

Litter plays an important role in seedling establishment (emergence, survival, and early growth). Here, we performed a meta-analysis on 404 datasets from 33 independent studies to analyze the effects of litter cover on seedling emergence, survival, height, and biomass (root, stem, leaf, and total). Each dataset was stratified according to experimental conditions, litter type (broadleaf versus needle litter), litter amount (thickness), and seed size. The results showed that litter cover had an overall negative effect on seedling emergence and survival, a neutral effect on root, leaf, total biomass, and a positive effect on stem biomass and seedling height than the no-litter cover control. Compared to thin (<250 g m−2) and medium (250–500 g m−2) litter layers, thick litter (>500 g m−2) was more detrimental for seedling emergence, survival, and total biomass, which could be an adaptation mechanism to prevent the growth of young seedling among high densities of other plants (trees). Broadleaf litter cover had a stronger negative effect on seedling emergence and total biomass than needle litter. Litter cover had a stronger negative effect on emergence of small seeds than on emergence of larger seeds. Similarly, litter cover had a stronger overall negative effect on seedling emergence than on seedling survival. In field and common garden experiments, litter effects were negative for emergence and positive for total biomass. In glasshouse and germination chamber experiments, litter effects were negative for emergence, survival and total biomass. These findings would contribute to advancements in forest management, improving conservation and restoration efforts.
Incorporation of Natural and Recombinant Collagen Proteins within Fmoc-Based Self-Assembling Peptide Hydrogels
Authors: Vitale Mattia , Ligorio Cosimo , Smith Ian P. , Richardson Stephen M. , Hoyland Judith A. , Bella Jordi
Published: April 2022

Hydrogel biomaterials mimic the natural extracellular matrix through their nanofibrous ultrastructure and composition and provide an appropriate environment for cell–matrix and cell–cell interactions within their polymeric network. Hydrogels can be modified with different proteins, cytokines, or cell-adhesion motifs to control cell behavior and cell differentiation. Collagens are desirable and versatile proteins for hydrogel modification due to their abundance in the vertebrate extracellular matrix and their interactions with cell-surface receptors. Here, we report a quick, inexpensive and effective protocol for incorporation of natural, synthetic and recombinant collagens into Fmoc-based self-assembling peptide hydrogels. The hydrogels are modified through a diffusion protocol in which collagen molecules of different molecular sizes are successfully incorporated and retained over time. Characterization studies show that these collagens interact with the hydrogel fibers without affecting the overall mechanical properties of the composite hydrogels. Furthermore, the collagen molecules incorporated into the hydrogels are still biologically active and provide sites for adhesion and spreading of human fibrosarcoma cells through interaction with the α2β1 integrin. Our protocol can be used to incorporate different types of collagen molecules into peptide-based hydrogels without any prior chemical modification. These modified hydrogels could be used in studies where collagen-based substrates are required to differentiate and control the cell behavior. Our protocol can be easily adapted to the incorporation of other bioactive proteins and peptides into peptide-based hydrogels to modulate their characteristics and their interaction with different cell types.
Formulation and Evaluation of Nano Lipid Carrier-Based Ocular Gel System: Optimization to Antibacterial Activity
Authors: Gilani Sadaf Jamal , Jumah May Nasser bin , Zafar Ameeduzzafar , Imam Syed Sarim , Yasir Mohd , Khalid Mohammad , Alshehri Sultan , Ghuneim Mohammed M. , Albohairy Fatima M.
Published: April 2022

The present research work was designed to prepare Azithromycin (AM)-loaded nano lipid carriers (NLs) for ocular delivery. NLs were prepared by the emulsification–homogenization method and further optimized by the Box Behnken design. AM-NLs were optimized using the independent constraints of homogenization speed (A), surfactant concentration (B), and lipid concentration (C) to obtain optimal NLs (AM-NLop). The selected AM-NLop was further converted into a sol-gel system using a mucoadhesive polymer blend of sodium alginate and hydroxyl propyl methyl cellulose (AM-NLopIG). The sol-gel system was further characterized for drug release, permeation, hydration, irritation, histopathology, and antibacterial activity. The prepared NLs showed nano-metric size particles (154.7 ± 7.3 to 352.2 ± 15.8 nm) with high encapsulation efficiency (48.8 ± 1.1 to 80.9 ± 2.9%). AM-NLopIG showed a more prolonged drug release (98.6 ± 4.6% in 24 h) than the eye drop (99.4 ± 5.3% in 3 h). The ex vivo permeation result depicted AM-NLopIG, AM-IG, and eye drop. AM-NLopIG exhibited significant higher AM permeation (60.7 ± 4.1%) than AM-IG (33.46 ± 3.04%) and eye drop (23.3 ± 3.7%). The corneal hydration was found to be 76.45%, which is within the standard limit. The histopathology and HET-CAM results revealed that the prepared formulation is safe for ocular use. The antibacterial study revealed enhanced activity from the AM-NLopIG.
Effect of NaCl on the Rheological, Structural, and Gelling Properties of Walnut Protein Isolate-κ-Carrageenan Composite Gels
Authors: Lei Yuqing , Ouyang Hui , Peng Wu , Yu Xiongwei , Jin Long , Li Shugang
Published: April 2022

In this study, we discovered that a certain concentration of Na+ (15 mM) significantly improved the bond strength (12.94 ± 0.93 MPa), thermal stability (72.68 °C), rheological properties, and textural attributes of walnut protein isolate (WNPI)-κ-carrageenan (KC) composite gel. Electrostatic force, hydrophobic interaction, hydrogen bond, and disulfide bond were also significantly strengthened; the α-helix decreased, and the β-sheet increased in the secondary structure, indicating that the protein molecules in the gel system aggregated in an orderly manner, which led to a much denser and more uniform gel network as well as improved water-holding capacity. In this experimental research, we developed a new type of walnut protein gel that could provide technical support for the high-value utilization and quality control of walnut protein.
No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients—A 10-Year Follow-Up Study in the Polish Population
Authors: Totoń Ewa , Jacczak Barbara , Barczak Wojciech , Jagielski Paweł , Gryczka Robert , Hołysz Hanna , Grodecka-Gazdecka Sylwia , Rubiś Błażej
Published: April 2022

Many intensive studies are devoted to identifying novel cancer diagnostics or therapy strategies that would boost cancer therapy efficacy and recovery rates. Importantly, polymorphisms in the genes coding for ABC family proteins were considered good candidates for cancer development risk or cancer drug resistance markers. For this reason, we decided to assess the contribution of ABCB1’s most common variants (i.e., G2677T/A in exon 21/rs2032582 and C3435T in exon 26/rs1045642) to the cancer therapy response in breast cancer patients. A 10-year follow-up analysis of 157 breast cancer patients was performed. Clinical assessment, ABCB1 polymorphism status, estrogen/progesterone/human epidermal receptors status, and other characteristics were compared according to the follow-up status using the Chi-square statistic. For the analysis of overall survival curves in TCGA breast cancer patients, the Xena browser was used. We show that neither 2677 nor 3435 polymorphisms contributed to the survival of breast cancer patients. Interestingly, but not surprisingly, estrogen and progesterone receptors status were good prognostic factors and positively correlated with a disease-free survival for up to 10 years. To summarize, ABCB1 polymorphisms status may be one of the numerous factors that affect cancer development. However, they may not be the critical ones when it comes to risk or recovery assessment. Consequently, they may not be treated as reliable prognostic or predictive markers in breast cancer patients’ evaluation, which supports the previous findings and current knowledge.
A Series of 14 Polish Patients with Thrombotic Events and PC Deficiency-Novel c.401-1G>A PROC Gene Splice Site Mutation in a Patient with Aneurysms
Authors: Weronska Anna , Potaczek Daniel P. , Oto Julia , Medina Pilar , Undas Anetta , Wypasek Ewa
Published: April 2022

Objectives: Protein C (PC) deficiency is an inherited thrombophilia with a prevalence of 0.5% in the general population and 3% in subjects with a first-time deep vein thrombosis (DVT). Here we report a series of 14 PC-deficient Polish patients with comprehensive clinical and molecular characteristics, including long-term follow-up data and a deep mutational analysis of the PROC gene. Patients and Methods: Fourteen unrelated probands (mean ± SD age 43.8 ± 13.0 years) with suspicion of PC deficiency, who experienced thromboembolic events and a majority of whom received anticoagulants (92.8%), were screened for PROC mutations by sequencing the nine PROC exons and their flanking intron regions. Results: Ten probands (71.4%) had missense mutations, two patients (14.3%) carried nonsense variants, and the other two subjects (14.3%) had splice-site mutations, the latter including the c.401-1G>A variant, reported here for the very first time. The proband carrying the c.401-1A allele had a hepatic artery aneurysm with a highly positive family history of aneurysms and the absence of any mutations known to predispose to this vascular anomaly. Conclusion: A novel detrimental PROC mutation was identified in a family with aneurysms, which might suggest yet unclear links of thrombophilia to vascular anomalies, including aneurysms at atypical locations in women. The present case series also supports data indicating that novel oral anticoagulants (NOACs) are effective in PC deficient patients.
Essential Oil Chemotypes of Four Vietnamese Curcuma Species Cultivated in North Alabama
Authors: Duong Lam , Mentreddy Srinivasa Rao , Satyal Rakesh , Satyal Prabodh , Setzer William N.
Published: April 2022

Curcuma (turmeric) species are important culinary and medicinal plants, and the essential oils of Curcuma rhizomes have demonstrated promising pharmacological properties. The essential oils (EOs) of Curcuma species possess a wide variety of pharmacological properties, including anti-inflammatory, anticancerous, antiproliferative, hypocholesterolemic, antidiabetic, antirheumatic, hypotensive, antioxidant, antimicrobial, antiviral, antithrombotic, antityrosinase, and cyclooxygenase-1 (COX-1) inhibitory activities, among others. Curcuma oils are also known to enhance immune function, promote blood circulation, accelerate toxin elimination, and stimulate digestion. C. longa (turmeric) and C. zedoaria (zedoary) are the most extensively studied species of Curcuma due to their high commercial value. There is some interest in expanding the cultivation of Curcuma species to the southern regions in North America where the climate is favorable. The purpose of this work was to examine the rhizome essential oil composition of four species of Curcuma (C. aromatica, C. caesia, C. longa, C. zanthorrhiza) that were obtained from Vietnam and cultivated in North Alabama. The rhizome essential oils were obtained by hydrodistillation and analyzed by gas chromatographic techniques. The essential oils of C. aromatica were dominated by curzerenone (14.7–18.6%), germacrone (10.7–14.7%), 1,8-cineole (5.2–11.7%), and an unidentified component (8.7–11.0%). The major components in C. longa rhizome oil were ar-turmerone (8.3–36.1%), α-turmerone (12.7–15.2%), β-turmerone (5.0–15.4%), α-zingiberene (4.6–13.9%), and β-sesquiphellandrene (4.6–10.0%). The essential oils of C. caesia and C. zanthorrhiza were rich in curzerenone, curdione, and germacrone. These adapted turmeric varieties in North Alabama have potential use for medical purposes and medicinal plant oil market demands in the U.S.
Dry Matter, Starch Content, Reducing Sugar, Color and Crispiness Are Key Parameters of Potatoes Required for Chip Processing
Authors: Islam Md Mazadul , Naznin Sauda , Naznin Afroz , Uddin Md Nasir , Amin Md Nurul , Rahman Md Mushfiqur , Tipu Mohammad Monirul Hasan , Alsuhaibani Amnah Mohammed , Gaber Ahmed , Ahmed Sharif
Published: April 2022

To make potato production more sustainable for smallholder farmers, product diversification through processing is critical. On the other hand, the processing sector mandated some stringent standards in order to maintain product quality, hence potato quality evaluations are required for chip processing industries. Specific gravity, starch, reducing sugars, tuber dry matter, and chip color are all important characteristics to consider for processing. This study was designed to find suitable potato varieties with satisfactory attributes for processing chips, in comparison with other processing potato varieties. Keeping this in mind, the study was performed during the winter season of 2019–2020 and 2020–2021 in Bangladesh. Six processing types of potato varieties viz. BARI Alu-25 (Asterix), BARI Alu-28 (Lady Rosetta), BARI Alu-29 (Courage), BARI Alu-68 (Atlantic), BARI Alu-70 (Destiny), and BARI Alu-71 (Dolly) were evaluated for different quality parameters (specific gravity, dry matter, starch content, reducing sugar, chip color, and crispiness). The result of the study showed an ample variation in the studied parameters among the potato varieties. Among the varieties, BARI Alu-28 (Lady Rosetta) and BARI Alu-29 (Courage) were found better for all the quality parameters, such as dry matter, starch, reducing sugar, chip color, and crispiness, and could be recommended for the processing industries.
Is the Systemic Agency Capacity of Long-Term Care Organizations Enabling Person-Centered Care during the COVID-19 Pandemic? A Repeated Cross-Sectional Study of Organizational Resilience
Authors: Pfaff Holger , Pförtner Timo-Kolja , Banaszak-Holl Jane , Hu Yinhuan , Hower Kira
Published: April 2022

The COVID-19 pandemic has strained long-term care organization staff and placed new demands on them. This study examines the role of the general ability and power of a long-term care organization to act and react collectively as a social system, which is called systemic agency capacity, in safeguarding the provision of person-centered care during a crisis. The question of how the systemic agency capacity of long-term care organizations helps to ensure person-centered care during the pandemic is an open research question. We conducted a pooled cross-sectional study on long-term care organizations in Germany during the first and second waves of the pandemic (April 2020 and December 2020–January 2021). The sample consisted of 503 (first wave) and 294 leaders (second wave) of long-term care organizations. The top managers of these facilities were asked to report their perceptions of their facility’s agency capacity, measured by the AGIL scale, and the extent to which the facility provides person-centered care. We found a significant positive association between the leaders’ perceptions of systemic agency capacity and their perceptions of delivered person-centered care, which did not change over time. The results tentatively support the idea that fostering the systemic agency capacity of long-term care organizations facilitates their ability to provide quality routine care despite environmental shocks such as the COVID-19 pandemic.
Gendered Experiences of Parent–Child Communication on Sexual and Reproductive Health Issues: A Qualitative Study Employing Community-Based Participatory Methods among Primary Caregivers and Community Stakeholders in Rural South-Western Uganda
Authors: Achen Dorcus , Nyakato Viola N. , Akatukwasa Cecilia , Kemigisha Elizabeth , Mlahagwa Wendo , Kaziga Ruth , Ruzaaza Gad Ndaruhutse , Rukundo Godfrey Z. , Michielsen Kristien , Neema Stella , Coene Gily
Published: April 2022

Open and positive parent–child communication about sexual and reproductive health (SRH) is known to reduce negative SRH outcomes for young people. However, socio-cultural influences can inhibit meaningful SRH communication. Restrictive gender norms threaten the SRH of adolescents, as they make adolescent boys more likely to engage in risky sexual behavior and make girls more vulnerable to negative SRH outcomes. This study intended to critically understand the impact of gender norms and expectations on parent–child SRH communication in rural south-western Uganda. Methods: The study adopted a community-based participatory approach using community stakeholder engagement meetings (n = 2), in-depth interviews (n = 12), and three focus group discussions with parents (n = 18). The study considered biological parents, step-parents, grandparents, uncles and aunties, as long as they were primary caregivers of adolescents aged 10–14. Results: Participants elaborated on the socio-cultural aspects that shaped their experiences of parent–child SRH communication such as cultural gender norms, religion, and media influences. They also referred to socio-economic challenges, lack of knowledge, and the role of peers and schools. Conclusions: There is need for community-based interventions to improve parent–child SRH communication to address the deeply rooted cultural and gender contexts in rural south-western Uganda.
Evaluation of Household Preparedness and Risk Factors for Cutaneous Leishmaniasis (CL) Using the Community Assessment for Public Health Emergency Response (CASPER) Method in Pakistan
Authors: Numan Muhammad , Naz Shumaila , Gilani Rehama , Minhas Azhar , Ahmed Haroon , Cao Jianping
Published: April 2022

(1) Background: In endemic areas of Pakistan, local community knowledge and attitudes towards cutaneous leishmaniasis (CL) are critical elements in the effective control and management of the disease. A cross-sectional epidemiologic design was used to assess the disease concern, preparedness, practices, and preventive behavior of the households and to assist the personnel and health care professionals in strengthening their planning efforts and awareness of CL. (2) Methods: A two-stage cluster sampling process, i.e., Community Assessment for Public Health Emergency Response (CASPER) was conducted from September 2020 to March 2021 on present household-level information about community needs and health status regarding CL in a cost-effective, timely, and representative manner. (3) Results: In the current study, 67% of the respondents were aware of CL and its causative agent and showed a low level of pandemic preparedness. The majority (74%) of the respondents mentioned that they did not avoid sandfly exposure areas. The majority (84%) of respondents had unsatisfactory behavior towards using bed nets, sprays, or repellents. (4) Conclusion: In endemic areas of Pakistan, the inadequate concern and low preparedness of the local community toward CL are critical aspects in efficient control and management of the disease.
Effects of Nursing Diabetes Self-Management Education on Glycemic Control and Self-Care in Type 1 Diabetes: Study Protocol
Authors: Romero-Castillo Rocío , Pabón-Carrasco Manuel , Jiménez-Picón Nerea , Ponce-Blandón José Antonio
Published: April 2022

(1) Background: Type 1 diabetes is a chronic disease that creates a high demand and responsibility for patient self-care. Patient education, self-care training and the management of derived complications are great challenges for nurses. The objective of this project is to evaluate the efficacy of a therapeutic education program for type 1 diabetes. (2) Methods: Participants recruited to the study will be adult patients with diagnosed type 1 diabetes attending the clinic at the study site. A nurse diabetes educator will deliver a four-session education program. A two-group randomized controlled trial will be used in this study, with an intervention group and a control group. The subjects included in the experimental group will attend some health education sessions, while control group participants will receive the existing standard care provided by the endocrinology and nutrition unit of the hospital. Measurements and evaluations will be conducted at the baseline prior to the intervention and at 1 and 3 months from the intervention. (3) Conclusions: The primary outcome is improving patients’ knowledge about diet and treatment management. Secondary outcomes are improving patients’ glycemic control and mood. The findings from this study will help to determine the effect of diabetes education about self-care and treatment in patients with diabetes, as well as helping to decrease short-term and long-term complications and reduce health care costs.
Central American Parents’ Preferences for Content and Modality for a Family-Centered Intervention to Promote Healthful Energy Balance-Related Behaviors of Their Preschool-Age Children
Authors: Díaz Elizabeth N. , Le Qun , Campos Daniel , Reyes Jesnny M. , Wright Julie A. , Greaney Mary L. , Lindsay Ana Cristina
Published: April 2022

This formative research used a cross-sectional survey to assess interest in informational content and intervention modalities for the design of an early childhood obesity prevention intervention for Central American families from the Northern Triangle countries (El Salvador, Guatemala, and Honduras) living in the United States. A total of 74 parents (36 mothers, 38 fathers) with a mean age of 31.6 years (SD = 5.6) completed the survey; 59.5% of whom were born outside of the United States. Although most parents reported being very interested in receiving information related to the seven assessed energy balance-related behaviors, there were significant differences by parents’ gender and nativity. Most parents endorsed remote modalities for content delivery via text/SMS, WhatsApp, and e-mail. However, respondents were also receptive to in-person delivery provided by community health workers. There were also significant differences in parents’ preferences for intervention modalities by parents’ gender and nativity. Future steps should include investigating different intervention modalities and their integration into a linguistic and culturally sensitive family-based intervention to promote healthful energy balance-related behaviors of preschool-age children in Central American families originating from the Northern Triangle countries.
Athletes and Coaches through the COVID-19 Pandemic: A Qualitative View of Goal Management
Authors: Costa Sergio , De Gregorio Eugenio , Zurzolo Lisa , Santi Giampaolo , Ciofi Edoardo Giorgio , Di Gruttola Francesco , Morgilli Luana , Montesano Cristina , Cavallerio Francesca , Bertollo Maurizio , di Fronso Selenia
Published: April 2022

Since the end of 2019 and throughout 2020, the world has been devastated by the COVID-19 pandemic. The sports world suddenly had to deal with a massive reorganization of events with important implications for the physical and psychological preparation of athletes and coaches. The purpose of this study was to explore how these changes impacted coaches’ and athletes’ goal-setting strategies and their experience of goal adjustment. As part of a wider mixed-method project involving 2162 coaches and 1354 athletes, an online qualitative survey was used, and data collected were analyzed using reflexive thematic analysis. Findings highlighted three overarching themes, in response to goal adjustment: “Moving on toward new goals”, “Letting go of goals”, and “Trying to hold on”, with several themes and sub-themes identifying different nuances of athletes’ and coaches’ experiences. The implications of such findings for the mental preparation of high-level athletes are discussed in two ways. Firstly, in light of existing literature on goal setting from an applied perspective; secondly, in the broader perspective of the sports culture and the application of our themes to other challenging moments that sports professionals might encounter.
What Drives Land Abandonment in Core Grain-Producing Areas? Evidence from China
Authors: Wang Yumeng , Li Jiaxu , Kong Xiangzhi
Published: April 2022

Food security remains a major issue for developing countries. Reducing arable land abandonment (ALA) is crucial to ensuring food security. In China, the ‘decline in both quantity and quality’ of arable land resources, especially in major grain-producing areas, has become increasingly serious. This study uses fuzzy set qualitative comparative analysis (fsQCA) to explore the core conditions and combinations of paths leading to explicit and implicit abandonment using 30 typical cases in the main grain-producing areas of Hubei Province. The results show that (1) three combined pathways lead to explicit ALA (EALA) and that two pathways lead to implicit ALA (IALA); (2) laborer health (LH) is the core condition leading to EALA; and (3) LH, agricultural laborer (AL), per capita income (PCI) and social relationships (SRs) are the core conditions leading to IALA. To effectively alleviate ALA, the government should improve production conditions, pay attention to laborer health issues, improve agricultural returns and strengthen food security publicity and guidance, thereby promoting the rational use of arable land in these areas. The findings in this study link the changes in arable land use and provide a reference for other developing countries in ensuring food security.
Telemedicine in the COVID-19 Era: A Narrative Review Based on Current Evidence
Authors: Nittari Giulio , Savva Demetris , Tomassoni Daniele , Tayebati Seyed Khosrow , Amenta Francesco
Published: April 2022

During the recent COVID-19 pandemic, healthcare providers have been encouraged to increase their use of telemedicine and to adopt telemedicine platforms for the majority of their clients who have chronic illnesses. Due to the outbreak itself, almost all countries worldwide were placed under emergency lockdowns. In this paper, we reviewed the literature regarding the use of telemedicine during the COVID-19 pandemic. Consequentially, we identified the adoption of telemedicine in various countries worldwide and evaluated their future steps in order to increase the adoption of e-health technologies. As a result of COVID-19, the e-health agenda, especially telemedicine, has been accelerated in several countries. COVID-19 is affecting individuals’ daily lives and has created major difficulties in the management of healthcare facilities for both infected and non-infected patients. A large portion of the rapid increase in the use of telemedicine can be attributed to evidence from previous pandemics as well as progress made by the field in response to COVID-19, especially in industrialized countries. A lack of effective treatment, large numbers of unvaccinated individuals, as well as social distancing and lockdown measures suggest telemedicine is the safest and most appropriate way of working with patients and doctors. In spite of this willingness, a large number of barriers need to be overcome in order for the telemedicine system to function properly and effectively throughout countries. In order for telemedicine to be sustainable and beneficial beyond the pandemic, several technical, educational, infrastructure, legal, and economic issues must be addressed and solved.
Toward an Ideal Particle Swarm Optimizer for Multidimensional Functions
Authors: Charilogis Vasileios , Tsoulos Ioannis G.
Published: April 2022

The Particle Swarm Optimization (PSO) method is a global optimization technique based on the gradual evolution of a population of solutions called particles. The method evolves the particles based on both the best position of each of them in the past and the best position of the whole. Due to its simplicity, the method has found application in many scientific areas, and for this reason, during the last few years, many modifications have been presented. This paper introduces three modifications to the method that aim to reduce the required number of function calls while maintaining the accuracy of the method in locating the global minimum. These modifications affect important components of the method, such as how fast the particles change or even how the method is terminated. The above modifications were tested on a number of known universal optimization problems from the relevant literature, and the results were compared with similar techniques.
Myocardial Function during Ventilation with Lower versus Higher Positive End-Expiratory Pressure in Patients without ARDS
Authors: Algera Anna Geke , Pierrakos Charalampos , Botta Michela , Zimatore Claudio , Pisani Luigi , Tuinman Pieter-Roel , Bos Lieuwe D. J. , Lagrand Wim K. , Gama de Abreu Marcello , Pelosi Paolo , Serpa Neto Ary , Schultz Marcus J. , Cherpanath Thomas G. V. , Paulus Frederique
Published: April 2022

The aim of this study was to investigate whether lower PEEP (positive end-expiratory pressure) had beneficial effects on myocardial function among intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) compared to higher PEEP. In this pre-planned substudy of a randomized controlled trial (RELAx), comparing lower to higher PEEP, 44 patients underwent transthoracic echocardiography. The exclusion criteria were known poor left ventricular function and severe shock requiring high dosages of norepinephrine. To create contrast, we also excluded patients who received PEEP between 2 cmH2O and 7 cmH2O in the two randomization arms of the study. The primary outcome was the right ventricular myocardial performance index (MPI), a measure of systolic and diastolic function. The secondary outcomes included systolic and diastolic function parameters. A total of 20 patients were ventilated with lower PEEP (mean ± SD, 0 ± 1 cmH2O), and 24 patients, with higher PEEP (8 ± 1 cmH2O) (mean difference, −8 cmH2O; 95% CI: −8.1 to −7.9 cmH2O; p = 0.01). The tidal volume size was low in both groups (median (IQR), 7.2 (6.3 to 8.1) versus 7.0 (5.3 to 9.1) ml/kg PBW; p = 0.97). The median right ventricular MPI was 0.32 (IQR, 0.26 to 0.39) in the lower-PEEP group versus 0.38 (0.32 to 0.41) in the higher-PEEP group; the median difference was –0.03; 95% CI: −0.11 to 0.03; p = 0.33. The other systolic and diastolic parameters were similar. In patients without ARDS ventilated with a low tidal volume, a lower PEEP had no beneficial effects on the right ventricular MPI.
Surgical Treatment in Hidradenitis Suppurativa
Authors: Shukla Ratnakar , Karagaiah Priyanka , Patil Anant , Farnbach Katherine , Ortega-Loayza Alex G. , Tzellos Thrasivoulos , Szepietowski Jacek C. , Giulini Mario , Schepler Hadrian , Grabbe Stephan , Goldust Mohamad
Published: April 2022

Hidradenitis suppurativa (HS) is a chronic, progressive inflammatory disorder of follicular occlusion with pubertal onset that presents as painful inflammatory nodules, sinus tracts, and tunnelling in apocrine-gland-rich areas, such as the axilla, groin, lower back, and buttocks. The disease course is complicated by contractures, keloids, and immobility and is often associated with a low quality of life. It is considered a disorder of follicular occlusion with secondary inflammation, though the exact cause is not known. Management can often be unsatisfactory and challenging due to the chronic nature of the disease and its adverse impact on the quality of life. A multidisciplinary approach is key to prompt optimal disease control. The early stages can be managed with medical treatment, but the advanced stages most likely require surgical intervention. Various surgical options are available, depending upon disease severity and patient preference. In this review an evidence-based outline of surgical options for the treatment of HS are discussed. Case reports, case series, cohort studies, case-control studies, and Randomized Clinical Trials (RCT)s available in medical databases regarding surgical options used in the treatment of HS were considered for the review presented in a narrative manner in this article.
The Role of Excessive Anticoagulation and Missing Hyperinflammation in ECMO-Associated Bleeding
Authors: Rajsic Sasa , Breitkopf Robert , Oezpeker Ulvi Cenk , Bukumirić Zoran , Dobesberger Moritz , Treml Benedikt
Published: April 2022

Extracorporeal membrane oxygenation (ECMO) is increasingly used in carefully selected patients with cardiac or respiratory failure. However, complications are common and can be associated with worse outcomes, while data on risk factors and outcomes are inconsistent and sparse. Therefore, we sought to investigate potential risk factors and predictors of haemorrhage and adverse events during ECMO and its influence on mortality. We retrospectively reviewed all patients on ECMO support admitted to intensive care units of a tertiary university centre in Austria. In a period of ten years, ECMO support was used in 613 patients, with 321 patients meeting the inclusion criteria of this study. Haemorrhage, occurring in more than one third of the included patients (123, 38%), represented the most common and serious ECMO complication, being associated with an increased one year mortality (51% vs. 35%, p = 0.005). The main risk factors for haemorrhage were severity of the disease (hazard ratio (HR) = 1.01, p = 0.047), a prolonged activated partial thromboplastin time (HR = 1.01, p = 0.007), and lower values of C-reactive protein (HR = 0.96, p = 0.005) and procalcitonin (HR = 0.99, p = 0.029). In summary, haemorrhage remained the main ECMO complication with increased mortality. Moreover, we reported a possible association of lower inflammation and bleeding during ECMO support for the first time. This generated a new hypothesis that warrants further research. Finally, we recommend stricter monitoring of anticoagulation especially in patients without hyperinflammation.
Association between Successful Palpation of the Cricothyroid Membrane and the 3-3-2 Rule for Predicting Difficult Airway in Female Patients Undergoing Non-Neck Surgery: A Prospective Observational Cohort Study
Authors: Lee So Yeon , Hong Da Kyung , Kim Chang Jae , Chung Mee Young , Lee Sanghoon , Chae Min Suk
Published: April 2022

Background: Prediction of difficult airway is important for airway management in patients undergoing surgery. The assessment of airway structures and establishment of protective airway strategies are essential to improve patient safety. However, the association between successful palpation of the cricothyroid membrane and airway predictions has not been fully elucidated in patients undergoing surgery. We investigated this in female patients undergoing non-neck surgery. Methods: A total of 68 female patients were enrolled in this prospective observational cohort study between January 2021 and June 2021 at Eunpyeong St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea. Exclusion criteria were male patients and those with neck pathology or neck surgery. The assessment of difficult airway was performed before the induction of anesthesia and was defined by one of the following conditions: inter-incisor distance < 3 fingerbreadths, hyoid-to-mental distance < 3 fingerbreadths, and thyroid-to-hyoid distance < 2 fingerbreadths (the “3-3-2 rule”). The accuracy of palpable identification of the cricothyroid membrane was confirmed by ultrasonography (US). The patients were divided into the non-difficult airway (NDA) group (n = 30) and the difficult airway (DA) group (n = 30). Results: The two groups were comparable in terms of age, but the DA group had higher body mass index (BMI). In airway assessment, 9 patients showed inter-incisor distance < 3 fingerbreadths, 3 patients showed hyoid-to-mental distance < 3 fingerbreadths, and 24 patients showed thyroid-to-hyoid distance < 2 fingerbreadths in the DA group. The rate of successful palpation of the cricothyroid membrane was higher in the patients without than in those with difficult airway variables. Conclusions: Patients with a positive 3-3-2 rule showed a poor palpability of cricothyroid membrane.
Impact of Social Determinants of Health on Women’s Satisfaction with Their Sexual Life and Its Relationship with the Use of Psychotropic Drugs: A Cross-Sectional Study
Authors: Ruiz de Viñaspre-Hernández Regina , Santolalla-Arnedo Iván , Garrido-Santamaría Rosana , Czapla Michał , Tejada-Garrido Clara Isabel , Sánchez-González Juan Luis , Sapiña-Beltrán Esther , Iriarte-Moreda Verónica , Colado-Tello María Estela , Gea-Caballero Vicente , Juárez-Vela Raúl
Published: April 2022

Sexual satisfaction (SS) is defined as an affective response arising from one’s subjective evaluation of the positive and negative dimensions associated with one’s sexual relationship. It is an important indicator of health. In women, SS has an important personal component consisting of the physical experiences of pleasure and the positive feelings and emotions that they experience in their affective-sexual relationships. The socioeconomic position is determined by income, educational level, and work, and it conditions women’s sexual health. We aimed to assess whether social determinants of health (income, education, work, and gender) are associated with women’s sexual satisfaction and to identify whether the impact of social determinants on sexual satisfaction differs with psychotropic consumption. We conducted a cross-sectional study designed to assess the association between variables related to the social determinants of health (work, education, income, and gender) and sexual satisfaction in women of reproductive age in La Rioja (Spain). The women in this study ranged in age from 17 to 52 years, with a mean age of 33.4 (Standar Deviation 8.6). Most were Spanish (82.9%), had undertaken non-compulsory specialized education (84%), and worked (72.7%). Regarding their relationships, 87% maintained monogamous relationships, 84.5% had stable relationships, and 65.7% lived with their partners. In total, 12.3% of the women were taking psychotropic drugs prescribed for the treatment of anxiety and/or depression. We observed that SS is significantly lower among women who have only undertaken compulsory education (Student-t = −4.745; p < 0.01), in those who have unstable affective-sexual relationships (Student-t = −2.553; p < 0.01), and in those who take psychotropic drugs (Student-t = −4.180, p < 0.01). We conclude that the social determinants of health such as education, not continuing to study beyond compulsory education, gender, and taking psychoactive drugs have a significant impact on women’s degree of satisfaction with their sexual life.