bluuebunny/crossref_metadata_2025 huggingface dataset:
HeaDax: A simple pre-surgical procedure for localizing superficial brain lesions in resource-limited environments
Authors: Akhaddar Ali
Published: December 2020

Background:

Intracranial convexity lesions are poorly defined by recognizable anatomical landmarks. Even in expert hands, exact localization of small subcortical lesion and its projection to the skull is sometimes unreliable and can cause potential surgical complications. In this report, a simple and handy technique for localizing superficial intracranial lesions on the scalp under computed tomography (CT)-scan guidance is described.

Methods:

This technique, HeaDax, is based on using extracranial landmarks. We constructed an isosceles square triangle with three pieces of copper electrical wire and placed it on the skin scalp. Then, we took a CT-scan but without the need of the classic head reference planes (e.g., orbitomeatal or along the orbital roof).

Results:

For the measurements, we need to have the intracranial lesion located on the CT slice with respect to the two landmarks which are the height and hypotenuse of the triangle. The promising preliminary results of HeaDax applied to a phantom skull model encourage us to use it successfully for our first patient presenting a right subcortial supramarginal retrorolandic cavernoma.

Conclusion:

HeaDax procedure is a good alternative for localizing superficial intracranial lesions on the skin scalp under CT-scan or magnetic resonance imaging guidance. It can be used as a substitute when stereotactic and neuronavigation systems are not easily available, especially in developing countries and in resource-limited environments. HeaDax has a true potential for further developments and applications in cranial surgery.
ESCALA DE LA ACTITUD ELECTORAL BASADA EN NEUROPOLÍTICA FRENTE A LOS ESTÍMULOS DE LA COMUNICACIÓN POLÍTICA EN JÓVENES Y ADULTOS DE LA CIUDAD DE PIURA, 2019
Authors: Abanto Velez Walter Ivan , Talledo Sebedón Danae De Lourdes , Vilchez Pacherres Brisset Keyla
Published: December 2020

Este trabajo de investigación tiene como objetivo principal determinar las propiedades psicométricas de la Escala de Neuropolitica en jóvenes y adultos de la ciudad de Piura. El diseño de investigación es de tipo instrumental ya que se basa en la construcción y evidencia de las propiedades psicométricas de un instrumento. La muestra de  estudio estuvo conformada por 385 jóvenes y adultos entre las edades de 20 a 35 años que radican en la ciudad de Piura. El instrumento construido es la escala de la actitud electoral basada en neuropolítica frente a los estímulos de la comunicación política. Los resultados reflejan que las propiedades psicométricas de la escala de la actitud electoral basada en neuropolítica frente a los estímulos de la comunicación política en jóvenes y adultos de la ciudad de Piura; son aceptables en su validez, confiabilidad y baremación, conformándose como un instrumento viable para su aplicación en la ciudad de Piura.
高校艺术设计专业教学中中国民间美术的应用探讨
Authors: 刘 大明
Published: December 2020

中国是一个具有文化内涵的国家，民间美术蕴含大量的历史文化与美术元素。高校艺术设计专业教学下引入中国民间美术能对民间文化进行传承，并实现传统美术元素与现代艺术设计的融合。论文以此为基础对高校艺术设计专业教学下中国民间美术应用展开探讨。
On Status Assessment and Management Strategy Formulation for Sustainable Aquaculture of the Hoven’s Carp (Leptobarbus hoevenii, Bleeker, 1851) in Jambi Municipality
Authors: Sutisna Ena , Affandi Ridwan , Kamal Mohammad , Yulianto Gatot
Published: December 2020

Hoven’s carp is an indigenous species of freshwater fish which is hihgly potential to be cultured in larger scale. It is omnivorous tend to be herbivorous fish so that it can save cost of feed. Sustainable management is needed in order to optimize the benefits that can be obtained from hoven’s carp aquaculture activities. It needs to pay attention to four dimensions of sustainable development (ecological, economic, socio-cultural and technological) to avoid problems of aquaculture. The purpose of this study was to assess the status and management strategy formulation for sustainable aquaculture of hoven’s carp in Jambi municipality using the Rapfish application. The results of the sustainability analysis of hoven’s carp aquaculture in Jambi municipality showed less sustainable with an index value of 46.60%, a stress value of 12.93% and a R2 value of 95.72%. Based on the leverage analysis, there are 14 sensitive attributes that are used to improve the sustainability of hoven’s carp aquaculture including availability of aquaculture land, land carrying capacity, marketing access, efficiency in the marketing chain, price fluctuations, availability of venture capital, knowledge of hoven’s carp fish aquaculture, fish farming experience, level of independence of farmers, availability of broodstock and seed, availability of supporting containers for aquaculture, feed independence.
MENGUKUR KETERAMPILAN BERFIKIR KRITIS PESERTA DIDIK TERHADAP ISUE-ISUE SOSIAL MELALUI PEMANFAATAN TEKNOLOGI INFORMASI (Studi Evaluasi Pada Peserta Didik kelas IV SD Muhammadiyah Manyar)
Authors: Marzuki Ismail
Published: December 2020

Tujuan penelitian ini adalah untuk memperoleh informasi secara mendalam tentang keterampilan berfikir kritis peserta didik terhadap isue-isue sosial dengan memanfaatkan Teknologi Informasi (TI). Jenis penelitian ini adalah penelitian evaluasi (evaluation research) dengan subjek penelitian enam siswa kelas 4 SD Muhammadiyah Manyar. Subjek tersebut terdiri atas 2 siswa dengan kecerdasan tinggi, 2 siswa dengan kecerdasan sedang, dan 2 siswa dengan kecerdasan rendah dengan jenis kelamin berbeda. Fokus penelitian adalah ingin menggali informasi tentang ketajaman berfikir kritis mereka dalam menentukan kebenaran sebuah informasi, kemampuan berargumen, dan kemampuan memecahkan masalah. Data-data penelitian dikumpulkan melalui interview dan test, dan setelah data terkumpul data kemudian dianalisis. Teknik analisis yang digunakan adalah teknik analisis deskriptif kualitatif. Hasil penelitian menunjukan bahwa pada aspek ketajaman berfikir kritis, seluruh kelompok siswa hasilnya sangat baik. Sementara untuk kemampuan berargumen kelompok dengan kecerdasan tinggi hasilnya baik, sedang kelompok sedang dan rendah hasilnya cukup. Terakhir kemampuan dalam memecahkan masalah hasilnya adalah peserta didik berkecerdasan tinggi nilainya sangat baik, sementara kelompok berkecerdasan sedang dan rendah hasilnya adalah cukup dan kurang.
Las traducciones francesas del teatro español del Siglo de Oro (siglos XIX-XXI)
Authors: Couderc Christophe
Published: December 2020

This article provides a description of translations and stage adaptations of Golden Age Spanish theatre from early 19th century to the present day. Fluctuations in taste, expectations and changing preferences of audiences, as well as the political context influenced the choice of which play was to be translated. Moreover, the degree of fidelity to the source text varies, as some are very faithful (written in verse, for example) while others are very free adaptations, and can be described as reinventions or rewritings rather than true translations. In spite of these infinite disparities between the texts considered, it is possible to detect a hierarchy that appears quite early between plays and Spanish authors, with Calderón playing a predominant role.
En busca del príncipe polaco calderoniano
Las traducciones de La vida es sueño de Pedro Calderón de la Barca y la presencia del teatro clásico español en Polonia
Authors: Baczyńska Beata
Published: December 2020

This essay presents Polish translations of La vida es sueño (Life is a dream) and El príncipe constante (The constant prince) to provide a survey of the historical and cultural context of Calderón’s reception in Poland.
Efficacy of citrulline supplementation to decrease the risk of pulmonary hypertension after congenital heart disease surgery. A local experience.
Authors: Silvera Ruiz Silene , Grosso Carola L , Tablada Margot , Cabrera Marcelo , Dodelson de Kremer Raquel , Juaneda Ernesto , Laróvere Laura E
Published: December 2020

Pulmonary hypertension (PH) is a major cause of morbi-mortality among patients with congenital heart disease (CHD) and also a potentially severe complication after surgical repair. Oral citrulline, a precursor to NO synthesis, is safe and efficacious for decreasing the risk of postoperative PH.

Objective: The aim of the present study was to investigate in pediatric patients the changes of plasma citrulline, arginine, homocysteine and nitric oxide (NO) metabolites and pulmonary artery pressures (PAP) pre-post cardiac surgery in order to describe our population status with regard to the risk of pulmonary hypertension and look for potential biomarkers for early detection and treatment.

Main results/Discussion: 16 Argentine pediatric patients with CHD undergoing cardiopulmonary bypass were randomized in two groups: (A) with and (B) without perioperative citrulline supplementation. We found that plasma citrulline median levels before surgery were lower in both groups respect to referential values, probably due to the poor nutritional status of our patients; only group A surpassed post-surgery the minimum recommended level to avoid PH. Furthermore, none of the patients in group A showed mean PAP higher than 20 mmHg, whereas in group B, 67% of the measurements were ≥ than the reference level.

Conclusions: We reaffirm that citrulline supplementation it is effective in reducing postoperative pulmonary hypertension and biomarkers could evidence patient status as a translational medicine application.
UV Reflectance Spectroscopy of the Copper/Copper Oxide System for Assessment of Solderability
Authors: Forney L. S. , Thierolf C. , Toleno B. , Parks G.
Published: December 2020

Surface changes of copper and copper coupons coated with organic solderability preservative (OSP) after accelerated aging were measured using UV Differential Reflectance Spectroscopy. A chemometric method has been developed that allows correlation of the spectroscopic results with independent measurements of the solderability of the copper and copper/OSP coupons using a wetting balance or sequential electrochemical reduction analysis (SERA). Based on the results of this study, a versatile instrument for the assessment of the solderability of printed wiring boards has been demonstrated. The instrument is currently in beta testing at several locations.
Case Study on Abnormal Electron-Optical Frequency Mapping Phenomena in Failure Analysis
Authors: Li Ang , Xiao Ryan , Guo Max , Li Jinglong , Liu Binghai
Published: December 2020

In recent years, laser reflectance modulation measurements are widely used in failure analysis. Among them, EOFM (Electron-Optical Frequency Mapping) technique is easy to operate and very practical. In this article, some images with abnormal EOFM phenomena and their corresponding defects are showing up, the causes of those abnormal EOFM phenomena are also pointed out. They prove that EOFM function is very effective for discovering open or high-impedance defects on metal trace and pinpointing short-circuit defects. In addition to the two aspects above, there are also some abnormal EOFM phenomena we couldn’t explain perfectly. We studied one of them and proposed two possible causes of the anomaly. After simulation experiment and calculation, it could be basically determined that the abnormal EOFM phenomenon was caused by the substrate noise current.
Cheyenne River Sioux Traditions and Resistance to the Dakota Access Pipeline
Authors: Goeckner Ryan , Daley Sean M. , Gunville Jordyn , Daley Christine M.
Published: December 2020

The No Dakota Access Pipeline resistance movement provides a poignant example of the way in which cultural, spiritual, and oral traditions remain authoritative in the lives of American Indian peoples, specifically the Lakota people. Confronted with restrictions of their religious freedoms and of access to clean drinking water due to construction of the Dakota Access Pipeline (DAPL), members of Lakota communities engaged with traditions specific to their communities to inform and structure the No DAPL resistance movement. A series of interviews conducted on the Cheyenne River Sioux Nation with tribal members reveal that Lakota spiritual traditions have been integral to every aspect of the movement, including the motivations for, organization of, and understanding of the future of the movement.
Identification of potential serum biomarkers for simultaneously classifying lung adenocarcinoma, squamous cell carcinoma and small cell carcinoma
Authors: Yu Jiangqing , Du Fen , Yang Liping , Chen Ling , He Yuanxiang , Geng Ruijin , Wu Le , Xie Baogang
Published: December 2020

BACKGROUND: Histological subtypes of lung cancer are crucial for making treatment decisions. However, multi-subtype classifications including adenocarcinoma (AC), squamous cell carcinoma (SqCC) and small cell carcinoma (SCLC) were rare in the previous studies. This study aimed at identifying and screening potential serum biomarkers for the simultaneous classification of AC, SqCC and SCLC. PATIENTS AND METHODS: A total of 143 serum samples of AC, SqCC and SCLC were analyzed by 1HNMR and UPLC-MS/MS. The stepwise discriminant analysis (DA) and multilayer perceptron (MLP) were employed to screen the most efficient combinations of markers for classification. RESULTS: The results of non-targeted metabolomics analysis showed that the changes of metabolites of choline, lipid or amino acid might contribute to the classification of lung cancer subtypes. 17 metabolites in those pathways were further quantified by UPLC-MS/MS. DA screened out that serum xanthine, S-adenosyl methionine (SAM), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCC) contributed significantly to the classification of AC, SqCC and SCLC. The average accuracy of 92.3% and the area under the receiver operating characteristic curve of 0.97 would be achieved by MLP model when a combination of those five variables as input parameters. CONCLUSION: Our findings suggested that metabolomics was helpful in screening potential serum markers for lung cancer classification. The MLP model established can be used for the simultaneous diagnosis of AC, SqCC and SCLC with high accuracy, which is worthy of further study.
DAF: An adaptive computing framework for multimedia data streams analysis
Authors: Li Jun , Li Chao , Tian Bin , Liu Yanzhao , Si Chengxiang
Published: December 2020

We consider the problem of efficiently online computing/filtering or analysis multimedia streams. In this scenario, we register a large scale of continuous analysis queries to filter pornographic stream items. Each query is a conjunction of filters. For instance, the query “does this image contain a people basking in the beach?” can be resolved by applying the conjunction of water, people, sand, sea filters successively on the stream item. However, the online evaluation of multimedia filters is indeed very expensive, fortunately there usually exist multiple filters shared among a lot of queries. In other words, each filter may occur in multiple queries. An open problem in such a filtering scenario is how to order the filters in an optimal sequence to achieve significant performance. Existing methods are based on a greedy strategy which orders the filters according to three factors (selectivity, popularity, cost). Although all these methods achieve good results, there are still some problems that haven’t addressed yet. First, the selectivity factor is set empirically, which can not adaptively adjust with multimedia stream. Second, the proportion relationships among the three factors (selectivity, cost, popularity) were not considerably explored. Under these observations,in this paper, we propose a Dynamic-Analytic hierarchy process Framework (DAF) which use a time-based compositional forecasting method, which is based on the idea of exponential smoothing, to deal with the factors’ proportion relationships dynamics. Experiments on both synthetic and real lift multimedia streams demonstrate that our proposed framework (DAF) provides much great adaptability in modeling the factors proportion relationships changing over multimedia stream environment.
Reinforcement learning based metric filtering for evolutionary distance metric learning
Authors: Ali Bassel , Moriyama Koichi , Kalintha Wasin , Numao Masayuki , Fukui Ken-Ichi
Published: December 2020

Data collection plays an important role in business agility; data can prove valuable and provide insights for important features. However, conventional data collection methods can be costly and time-consuming. This paper proposes a hybrid system R-EDML that combines a sequential feature selection performed by Reinforcement Learning (RL) with the evolutionary feature prioritization of Evolutionary Distance Metric Learning (EDML) in a clustering process. The goal is to reduce the features while maintaining or increasing the accuracy leading to less time complexity and future data collection time and cost reduction. In this method, features represented by the diagonal elements of EDML matrices are prioritized using a differential evolution algorithm. Further, a selection control strategy using RL is learned by sequentially inserting and evaluating the prioritized elements. The outcome offers the best accuracy R-EDML matrix with the least number of elements. Diagonal R-EDML focusing on the diagonal elements is compared with EDML and conventional feature selection. Full Matrix R-EDML focusing on the diagonal and non-diagonal elements is tested and compared with Information-Theoretic Metric Learning. Moreover, R-EDML policy is tested for each EDML generation and across all generations. Results show a significant decrease in the number of features while maintaining or increasing accuracy.
Hybrid recommendation model based on deep learning and Stacking integration strategy
Authors: Xie Xiaolan , Pang Shantian , Chen Jili
Published: December 2020

In the traditional recommendation algorithms, due to the rapid development of deep learning and Internet technology, user-item rating data is becoming increasingly sparse. The simple inner product interaction mode adopted by the collaborative filtering method has a cold start problem and cannot learn the complex nonlinear structural features between users and items, while the content-based algorithm encounters the difficulty of effective feature extraction. In response to this problem, a hybrid model is proposed based on deep learning and Stacking integration strategy. The traditional recommendation algorithm is first fused by using the Stacking integration strategy to make up for the shortcomings of the single recommendation algorithm to achieve better recommendation performance. The fusion-based model learns the more abstract and deeper nonlinear interaction features by deep learning technology, which makes the model performance gain further. The experiment comparison on the MovieLens-1m dataset shows that the proposed hybrid recommendation model can significantly improve the accuracy of rating prediction.
Content boosted hybrid filtering for solving pessimistic user problem in recommendation systems
Authors: Sivanaiah Rajalakshmi , Sakaya Milton R. , Mirnalinee T.T.
Published: December 2020

The main goal of a recommendation system is to recommend items of interest to users by analyzing their historical data. Content-based and collaborative filtering are the traditional recommendation strategies, each with its own strengths and weaknesses. Some of their weaknesses can be overcome by combining the two strategies. The resulting hybrid system performs qualitatively better than the traditional recommendation systems. However, historical data of some users may consist largely of only likes or only dislikes. Those users are termed as optimistic or pessimistic users respectively. On an average there are around 10 to 20% of pessimistic users present in a given dataset. For pessimistic users, whose profiles have mostly dislikes and very few likes, content-based filtering can hardly recommend any items of interest. In content-based filtering technique pessimistic users get poor recommendations of either uninteresting movies or no recommendations at all. This can be alleviated by boosting the content profiles of pessimistic users using the top-n recommendations of collaborative filtering. This content boosted hybrid filtering system provides a novel list of recommendations even for pessimistic users, with predictive accuracy better than that of a traditional content-based filtering system.
Slow Wave Sleep and EEG Delta Spectral Power are Associated with Cognitive Function in Parkinson’s Disease
Authors: Wood Kimberly H. , Memon Adeel A. , Memon Raima A. , Joop Allen , Pilkington Jennifer , Catiul Corina , Gerstenecker Adam , Triebel Kristen , Cutter Gary , Bamman Marcas M. , Miocinovic Svjetlana , Amara Amy W.
Published: December 2020

Background: Cognitive and sleep dysfunction are common non-motor symptoms in Parkinson’s disease (PD). Objective: Determine the relationship between slow wave sleep (SWS) and cognitive performance in PD. Methods: Thirty-two PD participants were evaluated with polysomnography and a comprehensive level II neurocognitive battery, as defined by the Movement Disorders Society Task Force for diagnosis of PD-mild cognitive impairment. Raw scores for each test were transformed into z-scores using normative data. Z-scores were averaged to obtain domain scores, and domain scores were averaged to determine the Composite Cognitive Score (CCS), the primary outcome. Participants were grouped by percent of SWS into High SWS and Low SWS groups and compared on CCS and other outcomes using 2-sided t-tests or Mann-Whitney U. Correlations of cognitive outcomes with sleep architecture and EEG spectral power were performed. Results: Participants in the High SWS group demonstrated better global cognitive function (CCS) (p = 0.01, effect size: r = 0.45). In exploratory analyses, the High SWS group showed better performance in domains of executive function (effect size: Cohen’s d = 1.05), language (d = 0.95), and processing speed (d = 1.12). Percentage of SWS was correlated with global cognition and executive function, language, and processing speed. Frontal EEG delta power during N3 was correlated with the CCS and executive function. Cognition was not correlated with subjective sleep quality. Conclusion: Increased SWS and higher delta spectral power are associated with better cognitive performance in PD. This demonstrates the significant relationship between sleep and cognitive function and suggests that interventions to improve sleep might improve cognition in individuals with PD.
Responsabilidade Internacional do Estado e os Direitos Humanos: O caso da Lei Maria da Penha no Brasil
Authors: Macêdo Karen Vanderlei
Published: December 2020

O objetivo central deste artigo é analisar a Responsabilidade Internacional do Estado brasileiro no caso de violência à mulher, em particular, ao caso que se tornou emblemático no Brasil e fora dele, que foi o acometimento de violência contra Maria da Penha Maia Fernandes praticada por, hoje, o seu ex-marido. Aqui a referência é o caso 12.051 (Maria da Penha Maia Fernandes versus Brasil), que foi aberto no dia 20 de agosto de 1998 pela Comissão Interamericana de Direitos Humanos da Organização dos Estados Americanos (OEA). A partir da interseção entre a violência doméstica cometida contra Maria da Penha Maia Fernandes e o instituto da Responsabilidade Internacional, verificou-se como a aplicação de um instituto internacional, por meio da Comissão Interamericana de Direitos Humanos da Organização dos Estados Americanos (CIDH-OEA) influenciou a criação de uma legislação que assegura os direitos das mulheres no Estado brasileiro.
PRIVATIZACIÓN DE LAS CÁRCELES – O QUIÉN SE BENEFICIA DE ESTE...
Authors: Nepomuceno Sabrina D. B , Gauto Jara Daniel , Andrade  Brisola Elisa Maria
Published: December 2020

El artículo tiene como objetivo reflexionar sobre el proceso de privatización de las cárceles en los últimos 20 años, en el ámbito de la ideología de la “guerra contra las drogas” y su relación con el aumento significativo del encarcelamiento de la población, cuyo motivo, en definitiva, es la comercialización de penas. Se trata de un estudio bibliográfico con autores de criminología crítica. Como resultado, es evidente, especialmente en Brasil, la efectividad de las asociaciones público-privadas que sirven a los intereses ideológicos del capital, señalando la violación de los Derechos Humanos.
Spor salonunda spor yapan kişilerde gıda takviyesi kullanım durumunun saptanması
Authors: Oruç Güler Özde Ezel , Anul Nejla
Published: December 2020

Amaç: Bu çalışma spor salonunda spor yapan kişilerin gıda takviyesi kullanım durumu belirlemek amacıyla yapılmıştır. Yöntem: İstanbul’da özel bir spor merkezinde 75 katılımcı ile 34 sorudan oluşan anket uygulaması ile gerçekleştirilmiştir. Anket verileri SPSS 24.0 paket programı kullanılarak analiz edilmiş olup verilerin değerlendirilmesinde frekans analizi, ortalama, minimum maksimum değer, standart sapma ve parametrik olmayan bulgular için Ki-kare testi kullanılmıştır. Çalışmanın etik kurul onayı alınmıştır. Bulgular: Gıda takviyesi kullanım durumuna bakıldığında; katılımcıların %65.3’ü kullanmadığını, %28’i sürekli kullandığını ve %6.7’si bazen kullandığını bildirmiştir. Gıda takviyesi kullanan kişilerin %50’si kas geliştirme, %19.2’si form tutma, %19.2’si yağ yakımı ve %11.5’i ise performans arttırma amacıyla gıda takviyesi kullanmakta olup, gıda takviyesi kullanan kişilerin %53.8’i protein tozu, %23.1’i dallı zincirli amino asit, %7.7’si aminoasit, %7.7’si kreatin, %3.8’i konguje linoleik asit ve %3.8’i L-karnitin kullandığı belirtilmiştir. Gıda takviyesi kullanan kişilerin %46.2’si spor eğitmeni, %34.6’sı kendi isteği ile %15.4’ü arkadaşı ve %3.8’i diyetisyen tarafından gıda takviyesi kullanımına yönlendirildiğini, gıda takviyesine ulaşımın %42.3’ünün internet, %23.1’inin eczane, %19.2’sinin spor eğitmeni ve %15.4’ünün mağaza yoluyla olduğu belirtilmiştir. Sonuç: Eğitim durumu ve gıda takviyesi kullanımı arasındaki ilişki anlamlı olduğu ve gıda takviyesi kullanımının eğitim seviyesi arttıkça arttığı sonucuna ulaşılmıştır. Egzersiz çeşidi ve protein tozu kullanımı arasındaki ilişki ise anlamsız bulunmuştur.
The Antibiotic Andrimid Produced by Vibrio coralliilyticus Increases Expression of Biosynthetic Gene Clusters and Antibiotic Production in Photobacterium galatheae
Authors: Buijs Yannick , Isbrandt Thomas , Zhang Sheng-Da , Larsen Thomas Ostenfeld , Gram Lone
Published: December 2020

The development and spread of multidrug resistant pathogens have reinforced the urgency to find novel natural products with antibiotic activity. In bacteria, orphan biosynthetic gene clusters (BGCs) far outnumber the BGCs for which chemistry is known, possibly because they are transcriptionally silent under laboratory conditions. A strategy to trigger the production of this biosynthetic potential is to challenge the microorganism with low concentrations of antibiotics, and by using a Burkholderia genetic reporter strain (Seyedsayamdost, Proc Natl Acad Sci 111:7266–7271), we found BGC unsilencing activity for the antimicrobial andrimid, produced by the marine bacterium Vibrio coralliilyticus. Next, we challenged another marine Vibrionaceae, Photobacterium galatheae, carrier of seven orphan BGCs with sub-inhibitory concentrations of andrimid. A combined approach of transcriptional and chemical measurements of andrimid-treated P. galatheae cultures revealed a 10-fold upregulation of an orphan BGC and, amongst others, a 1.6–2.2-fold upregulation of the gene encoding the core enzyme for biosynthesis of holomycin. Also, addition of andrimid caused an increase, based on UV-Vis peak area, of 4-fold in production of the antibiotic holomycin. Transcriptional measurements of stress response related genes in P. galatheae showed a co-occurrence of increased transcript levels of rpoS (general stress response) and andrimid induced holomycin overproduction, while in trimethoprim treated cultures attenuation of holomycin production coincided with a transcriptional increase of recA (SOS stress response). This study shows that using antimicrobial compounds as activators of secondary metabolism can be a useful strategy in eliciting biosynthetic gene clusters and facilitate natural product discovery. Potentially, such interactions could also have ecological relevant implications.
R-Wave Singularity: A New Morphological Approach to the Analysis of Cardiac Electrical Dyssynchrony
Authors: Zhan Ping , Li Tao , Shi Jinlong , Wang Guojing , Wang Buqing , Liu Hongyun , Wang Weidong
Published: December 2020

R-wave singularity (RWS) measures the intermittence or discontinuousness of R waves. It has been broadly used in QRS (QRS complex of electrocardiogram) detection, electrocardiogram (ECG) beats classification, etc. In this article, we novelly developed RWS to the analysis of QRS morphology as the measurement of ventricular dyssynchrony and tested the hypothesis that RWS could enhance the discrimination between control and acute myocardial infarction (AMI) patients. Holter ECG recordings were obtained from the Telemetric and Holter ECG Warehouse database, among which database Normal was extracted as normal controls (n = 202) and database AMI (n = 93) as typical subjects of autonomic nervous system dysfunction and cardiac electrical dyssynchrony with high risk for cardiac arrhythmias and sudden cardiac death. Experimental results demonstrate that RWS measured by Lipschitz exponent calculated from 5-min Holter recordings was significantly less negative in early AMI and late AMI than that in Normal subjects for overall, elderly, and elderly male groups, which suggested the heterogeneous depolarization of the ventricular myocardium during AMI. Receiver operating characteristic curve analyses show that combined with heart rate variability parameters, Lipschitz exponent provides higher accuracy in distinguishing between the patients with AMI and healthy control subjects for overall, elderly, elderly male, and elderly female groups. In summary, our study demonstrates the significance of using RWS to probe the cardiac electrical dyssynchrony for AMI. Lipschitz exponent may be valuable and complementary for existing cardiac resynchronization therapy and autonomic nervous system assessment.
The Helicopter Pilot—Swedish Hot-Area Policing From Above
Authors: Gerell Manne , Kardell Johan , Nilvall Kim
Published: December 2020

Hot spot policing is an established concept that is proven to reduce crime. It is mostly done through foot patrol or car patrols. In the present study it is tested whether helicopters can produce a deterrent policing effect to reduce the amount of vehicle arsons in Sweden on larger hot areas. Sweden tends to have elevated levels of vehicle arsons in August, with about 20% of police districts responsible for 50% of the cases. The risk narrative revolves around youth congregating in public places in deprived neighborhoods to generate disturbances, and the disruption of the risk narrative tested here is based on providing deterrence through helicopter police presence. During 6 weeks in August and September of 2019 police helicopters patrolled four police districts in Sweden to attempt to prevent vehicle arsons. Our data comprise police reports of vehicle arson, and time stamped satellite data over the location for police helicopters. The evaluation considers whether there is an intention to treat effect from this project, in addition to whether there is an effect of actual helicopter presence. The study finds no significant effect of intention to treat, nor of actual dosage.
Does Temperature Affect COVID-19 Transmission?
Authors: Kassem Aly Zein Elabdeen
Published: December 2020

This study utilizes the non-linear least squares method to estimate the impact of temperature on COVID-19 cases per million in forty-three countries, divided into three groups as follows: the first group is composed of thirteen countries that announced the first COVID-19 cases in January 2020, while the second and third groups contain thirteen and seventeen countries, respectively, that witnessed the pandemic for the first time in February and March of the same year. This relationship was measured after four time periods from the date of reporting the first case until April 1, April 15, May 15, and July 8, 2020. The results show an inverse relationship between COVID-19 cases per million and the temperature in the studies of the four-time periods for the three-country groups. These results were only significant statistically (p< 0.1) after 110.8, 164.8 days on average from the beginning of the pandemic in the case of “January” countries.
Methotrexate Gold Nanocarriers: Loading and Release Study: Its Activity in Colon and Lung Cancer Cells
Authors: Álvarez-González Beatriz , Rozalen Marisa , Fernández-Perales María , Álvarez Miguel A. , Sánchez-Polo Manuel
Published: December 2020

In the present study, the synthesis of gold nanoparticles (AuNPs) loaded with methotrexate (MTX) has been carried out in order to obtain controlled size and monodispersed nanocarriers of around 20 nm. The characterization study shows metallic AuNPs with MTX polydispersed on the surface. MTX is linked by the replacement of citrate by the MTX carboxyl group. The drug release profiles show faster MTX release when it is conjugated, which leads to the best control of plasma concentration. Moreover, the enhanced release observed at pH 5 could take advantage of the pH gradients that exist in tumor microenvironments to achieve high local drug concentrations. AuNP–MTX conjugates were tested by flow cytometry against lung (A-549) and colon (HTC-116) cancer cell lines. Results for A-549 showed a weaker dose–response effect than for colon cancer ones. This could be related to the presence of folate receptors in line HTC-116 in comparison to line A-549, supporting the specific uptake of folate-conjugated AuNP–MTX by folate receptor positive tumor cells. Conjugates exhibited considerably higher cytotoxic effects compared with the effects of equal doses of free MTX. Annexin V-PI tests sustained the cell death mechanism of apoptosis, which is normally disabled in cancer cells.
COMPARISON OF TURBINOPLASTY SURGERY EFFICACY IN PATIENTS WITH AND WITHOUT ALLERGIC RHINITIS AT MGMMC, JAMSHEDPUR
Authors: Jee Devendra , Jha Rohit Kumar , Hansda Bhimsen , Jana Debarshi
Published: December 2020

INTRODUCTION:
Turbinoplasty is a procedure that aims to reduce the size of the inferior turbinate through exuberant bone removal with high mucosal preservation. The procedure is recommended for patients with or without allergic rhinitis and those showing irreversible hypertrophy of inferior turbinates.
OBJECTIVE:
To evaluate the efficacy of inferior turbinoplasty for obstructive and non-obstructive symptoms in patients with or without allergic rhinitis.
METHODS:
Prospective study with 57 patients who underwent inferior turbinoplasty. They were evaluated for nasal obstruction, snoring, facial pressure, smell alterations, sneezing, nasal itching and runny nose symptoms, surgery time, and intraoperative bleeding. The last evaluation took place three months after surgery.
RESULTS:
Thirty-nine patients with allergic rhinitis and 18 without were assessed. Ninety days after surgery, 94.7% of patients showed degrees IV and V of breathing improvement; 89.5% showed moderate or complete improvement in snoring; all patients showed smell improvement (only one showed moderate improvement; all the others had full improvement); 95.5% experienced complete facial pressure improvement; and 89.7% showed moderate to complete improvement in nasal itching and runny nose symptoms, as well as in sneezing.
CONCLUSION:
The efficacy of inferior turbinoplasty was confirmed not only for obstructive symptoms, but also for non-obstructive symptoms in patients with and without allergic rhinitis.
Economic Evaluation of Adjuvant Trastuzumab Emtansine in Patients with HER2-Positive Early Breast Cancer and Residual Invasive Disease after Neoadjuvant Taxane and Trastuzumab–Based Treatment in Canada
Authors: Younis T. , Lee A. , Coombes M. E. , Bouganim N. , Becker D. , Revil C. , Jhuti G. S.
Published: December 2020

Background: In the katherine trial, adjuvant trastuzumab emtansine [T-DM1, Kadcyla (Genentech, South San Francisco, CA, U.S.A.)], compared with trastuzumab, significantly reduced the risk of recurrence or death by 50% (unstratified hazard ratio: 0.50; 95% confidence interval: 0.39 to 0.64; p < 0.0001) in patients with HER2-positive early breast cancer (ebc) and residual invasive disease after neoadjuvant systemic treatment. A cost–utility evaluation, with probabilistic analyses, was conducted to examine the incremental cost per quality-adjusted life–year (qaly) gained associated with T-DM1 relative to trastuzumab, given the higher per-cycle cost of T-DM1. Methods: A Markov model comprising a number of health states was used to examine clinical and economic outcomes over a lifetime horizon from the Canadian public payer perspective. Patients entered the model in the invasive disease-free survival (idfs) state, where they received either T-DM1 or trastuzumab. Transition probabilities between the health states were derived from the katherine trial, Canadian life tables, and published literature from other relevant clinical trials (emilia, cleopatra, and M77001). Resource use, costs, and utilities were derived from katherine, other clinical trials, published literature, provincial fee schedules, and clinical expert opinion. Sensitivity analyses were conducted for key assumptions and model parameters. Results: Compared with trastuzumab, adjuvant T-DM1 was associated with a cost savings of $8,300 per patient and a 2.16 incremental qaly gain; thus T-DM1 dominated trastuzumab. Scenario analyses yielded similar results, with T-DM1 dominating trastuzumab or producing highly favourable incremental cost–utility ratios of less than $10,000 per qaly. Conclusions: Adjuvant T-DM1 monotherapy is a cost-effective strategy compared with trastuzumab alone in the treatment of patients with HER2-positive ebc and residual invasive disease after neoadjuvant systemic treatment.
Check-list of Macroheterocera (Insecta, Lepidoptera) collected in 2019 in Mongolia by Russian entomological expeditions
Authors: Knyazev Svyatoslav A. , Makhov Ilya A. , Matov Alexey Yu. , Yakovlev Roman V.
Published: December 2020

The article provides the list of Macroheterocera (Lepidoptera), collected in Mongolia in two expeditions of Russian entomologists in 2019. The first travel (September 14−24) − Bayan-Ulgii, Khovd, and Gobi-Altai Aimaks; the second travel (June 24 – July 5) − Uvurkhangai, Bayanhongor, and Töw Aimaks. 21 species are indicated for the fauna of Mongolia for the first time: Idaea elongaria (Rambur, 1833) (Geometridae), Orgyia dubia (Tauscher, 1806), Thylacigyna antiquoides (Hübner, 1822), Ivela ochropoda (Eversmann, 1847), Catocala deducta Eversmann, 1843, C. desiderata Staudinger, 1888, C. neglecta Staudinger, 1888, (Püngeler, 1906), Autophila vespertalis (Staudinger, 1896) (Erebidae), Acronicta tridens ([Denis & Schiffermüller], 1775), Caradrina expansa Alphéraky, 1887, C. inopinata Hacker, 2004, Polymixis atossa (Wiltshire, 1941), P. rosinae (Bohatsch, 1908), Dasypolia maria Volynkin, 2012, Pseudohadena argyllostigma (Varga & L.Ronkay, 1991), Ctenoceratoda turpis (Staudinger, 1900), Mythimna l-album (Linnaeus, 1767), M. vitellina (Hübner, 1808), Dichagyris flammatra ([Denis & Schiffermüller], 1775), Agrotis psammocharis Boursin, 1950, Eugnorisma atrabaelbops Varga, 1975 (Noctuidae).
Analisis Ketimpangan Dan Faktor Yang Mempengaruhi Tingkat Ketimpangan Antar (Kabupaten/Kota) Di Provinsi Jawa Barat
Authors: Silviana Rizki , Tallo Amandus Jong
Published: December 2020

Provinsi Jawa Barat didukung oleh 17 sektor lapangan usaha dengan sumbangan tertinggi dari 3 sektor yaitu, sektor Industri Pengolahan sebesar 43,37 %, sektor Perdagangan Besar dan Eceran; Reparasi Mobil dan Sepeda Motor sebesar 15,60 % dan sektor Konstruksi sebesar 8,21 %. Ketimbangan antar kabupaten/kota di Provinsi Jawa Barat berdasarkan Indeks Williamson masuk kedalam kategori tinggi sekitar 1,43 yang terjadi di wilayah Tasikmalaya. Metode analisis tipologi klassen terbagi menjadi 4 klasifikasi pendekatan wilayah yaitu, Kuadran I (Daerah maju dan tumbuh cepat), Kuadran II.(Daerah maju tapi tertekan), Kuadran III.(Daerah berkembang cepat), dan Kuadran IV.(Daerah tertinggal). Faktor utama penyebabkan terjadinya ketimpangan antar wilayah yaitu, perbedaan sumberdaya alam, perbedaan kondisi demografis, kurang lancarnya mobilitas barang dan jasa, konsentrasi kegiatan ekonomi wilayah, dan alokasi dana pembangunan antar wilayah yang berbeda-beda.
REFUNDING THE EXPENSES OF PERSONS WITHOUT SET WAGE ASSISTING AD MINISTRATION OF JUSTICE
Authors: Терехов А.Ю. , Латыпов В.С.
Published: December 2020

Введение: в статье авторами подвергнуто анализу уголовно-процессуальное законодательство России, регламентирующее порядок возмещения расходов, связанных с участием в уголовном процессе лиц, оказывающих содействие отправлению правосудия, не имеющих постоянной заработной платы. В результате проведенного исследования установлено, что такой порядок и размеры выплат определены в соответствующем постановлении Правительства Российской Федерации, в которое не вносились изменения по корректировке размеров выплат с 2015 года.
Материалы и методы: методологическую базу исследования составили диалектический метод научного познания, логический, сравнительно-правовой, статистический методы, а также наблюдение и другие частные методы исследования правовых явлений.
Результаты исследования: авторы предлагают внести соответствующие изменения в Уголовно-процессуальный кодекс Российской Федерации (далее – УПК РФ), которые направлены на реализацию прав лиц, оказывающих содействие отправлению правосудия, связанных с получением возмещения расходов в связи с участием в уголовном судопроизводстве.
Обсуждение и заключения: представлен авторский подход, направленный на совершенствование законодательного механизма возмещения расходов лицам, оказывающим содействие отправлению правосудия. Сделаны выводы о необходимости нормативной коррекции: во-первых, наименования главы 8 УПК РФ; во-вторых, отдельных положений ч. 2 ст. 133 УПК РФ и, в-третьих, пересмотра размера вознаграждения, подлежащего выплате лицам, оказывающим содействие отправлению правосудия, не имеющим постоянной заработной платы.
Le football amateur sous le choc économique de la crise de la Covid-19 en France
Authors: Carin Yann , Andreff Wladimir
Published: December 2020

La propagation du Coronavirus (Covid-19) a entraîné l’arrêt des championnats professionnels et amateurs de football. L’objectif de l’article est de mettre en évidence le choc instantané et violent de cette crise sur le modèle de financement des clubs de football amateur en comparant leurs comptes avant la crise et à la fin de la saison en cours. Les mesures gouvernementales de soutien au sport sont prises en compte pour voir combien les clubs y ont eu recours.
Clarification du construit de l’intérêt en situation en éducation physique
Authors: Roure Cédric
Published: December 2020

L’objectif de cette recherche était de clarifier le construit de l’intérêt en situation en éducation physique, en validant une nouvelle échelle de mesure en appui sur trois facteurs mis en évidence dans des travaux en psychologie de l’éducation (Linnenbrinck-Garcia et al ., 2010, 2013). Quatre étapes successives ont été suivies : (1) le développement d’une version préliminaire à partir d’une approche déductive de la littérature scientifique et d’une sélection d’items, et d’une validation du contenu par un comité d’experts (2) une première étude avec 312 élèves ( Mage  = 13.4, ET  = 1.2) pour établir la structure factorielle et la fiabilité du construit ; (3) une deuxième étude avec 489 élèves ( Mage  = 13.9, ET  = 1.6) pour confirmer la structure factorielle ; et (4) une troisième étude avec 174 élèves ( Mage  = 14.5, ET  = 1.1) pour tester la validité prédictive de l’échelle de mesure en lien avec la théorie des buts d’accomplissements et sa validité divergente en lien avec la compétence perçue. Les résultats ont permis d’attester des qualités psychométriques d’une échelle de mesure en 12 items mesurant trois facteurs : le déclenchement d’un intérêt en situation (quatre items), le maintien d’un intérêt en situation basé sur les ressentis (quatre items) et le maintien d’un intérêt en situation basé sur les valeurs (quatre items). Cette structure factorielle présente désormais l’avantage d’être cohérente avec les deux premières étapes du modèle de développement de l’intérêt (Hidi & Renninger, 2006).
Factors Influencing the Adoption Intention of Artificial Intelligence for Public Engagement in Singapore
Authors: Karippur Nanda Kumar , Liang Shaohong , Balaramachandran Pushpa Rani
Published: December 2020

This study aims at examining the key factors influencing the adoption intention of artificial intelligence (AI)-enabled mobile application for public engagement. Digital technologies such as AI provide the opportunity for public agencies to be inclusive and invite citizens to participate in shaping and reshaping the future of public policies and methods of governance. The authors test the proposed research model and results highlight the significant roles of collaboration, hedonic motivation, reliability, and degree of app savviness in the adoption intention of AI application for public engagement. The article reports valuable insights and relevant implications for public agencies, service providers and researchers.
The COVID-19 pandemic: is it really just a flu? Focus on epidemiology
Authors: Tieri Claudia
Published: December 2020

As the main title ‘COVID-19 revolution: a new challenge for the internist’ states, the global coronavirus infection disease 2019 (COVID-19) pandemic represented a new challenge for the internists. This paper is part of a series of articles written during the difficult period of the ongoing global pandemic and published all together in this fourth issue of the Italian Journal of Medicine, with the aim of sharing the direct experiences of those who were the first to face this severe emergency, expressing each point of view in the management of COVID-19 in relation to other diseases. Each article is therefore the result of many efforts and a joint collaboration between many colleagues from the Departments of Internal Medicine or Emergency Medicine of several Italian hospitals, engaged in the front line during the pandemic. These preliminary studies therefore cover diagnostic tools available to health care personnel, epidemiological reflections, possible new therapeutic approaches, discharge and reintegration procedures to daily life, the involvement of the disease not only in the lung, aspects related to various comorbidities, such as: coagulopathies, vasculitis, vitamin D deficiency, gender differences, etc.. The goal is to offer a perspective, as broad as possible, of everything that has been done to initially face the pandemic in its first phase and provide the tools for an increasingly better approach, in the hope of not arriving unprepared to a possible second wave. This paper in particular deals with the epidemiology of COVID-19.