bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from YM155 Reverses Cisplatin Resistance in Head and Neck Cancer by Decreasing Cytoplasmic Survivin Levels
Authors: Kumar Bhavna , Yadav Arti , Lang James C. , Cipolla Michael J. , Schmitt Alessandra C. , Arradaza Nicole , Teknos Theodoros N. , Kumar Pawan
Published: April 2023

PDF file, 839KB, YM155 and cisplatin combination treatment significantly inhibits tumor cell proliferation. UM-SCC-74A cells were treated with YM155 or cisplatin (CDDP) alone or in combination. After 72 hrs, cell proliferation was assessed by MTT assay.
Supplementary Figure Legend from Sensitization of TRAIL-Induced Cell Death by 20(S)-Ginsenoside Rg3 via CHOP-Mediated DR5 Upregulation in Human Hepatocellular Carcinoma Cells
Authors: Lee Ju-Yeon , Jung Kyung Hee , Morgan Michael J. , Kang Yi-Rae , Lee Hee-Seung , Koo Gi-Bang , Hong Soon-Sun , Kwon Sung Won , Kim You-Sun
Published: April 2023

PDF file - 103K
Supplementary Figure 6 from Sensitization of TRAIL-Induced Cell Death by 20(S)-Ginsenoside Rg3 via CHOP-Mediated DR5 Upregulation in Human Hepatocellular Carcinoma Cells
Authors: Lee Ju-Yeon , Jung Kyung Hee , Morgan Michael J. , Kang Yi-Rae , Lee Hee-Seung , Koo Gi-Bang , Hong Soon-Sun , Kwon Sung Won , Kim You-Sun
Published: April 2023

PDF file - 233K, HL 7702 cells do not express high levels of anti-apoptotic proteins
Supplementary Figure 5 from Sensitization of TRAIL-Induced Cell Death by 20(S)-Ginsenoside Rg3 via CHOP-Mediated DR5 Upregulation in Human Hepatocellular Carcinoma Cells
Authors: Lee Ju-Yeon , Jung Kyung Hee , Morgan Michael J. , Kang Yi-Rae , Lee Hee-Seung , Koo Gi-Bang , Hong Soon-Sun , Kwon Sung Won , Kim You-Sun
Published: April 2023

PDF file - 628K, Human normal liver cells (HL 7702) can undergo TRAIL-induced cell death when sensitized by CHX, but not Rg3
Supplementary Figure 4 from Breast Cancer–Derived Bone Metastasis Can Be Effectively Reduced through Specific c-MET Inhibitor Tivantinib (ARQ 197) and shRNA c-MET Knockdown
Authors: Previdi Sara , Abbadessa Giovanni , Dalò Francesca , France Dennis S. , Broggini Massimo
Published: April 2023

PDF file - 49K
Supplementary Figure 4 from Sensitization of TRAIL-Induced Cell Death by 20(S)-Ginsenoside Rg3 via CHOP-Mediated DR5 Upregulation in Human Hepatocellular Carcinoma Cells
Authors: Lee Ju-Yeon , Jung Kyung Hee , Morgan Michael J. , Kang Yi-Rae , Lee Hee-Seung , Koo Gi-Bang , Hong Soon-Sun , Kwon Sung Won , Kim You-Sun
Published: April 2023

PDF file - 61K, Rg3-mediated, but not thapsigargin-mediated sensitization of TRAIL is CHOP dependent
Supplementary Figure 2 from Breast Cancer–Derived Bone Metastasis Can Be Effectively Reduced through Specific c-MET Inhibitor Tivantinib (ARQ 197) and shRNA c-MET Knockdown
Authors: Previdi Sara , Abbadessa Giovanni , Dalò Francesca , France Dennis S. , Broggini Massimo
Published: April 2023

PDF file - 32K
Supplementary Methods from Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner
Authors: McCarthy Anna R. , Sachweh Marijke C.C. , Higgins Maureen , Campbell Johanna , Drummond Catherine J. , van Leeuwen Ingeborg M.M. , Pirrie Lisa , Ladds Marcus J.G.W. , Westwood Nicholas J. , Laín Sonia
Published: April 2023

PDF file - 41K
Supplementary Table 5 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Authors: Allen Wendy L. , Stevenson Leanne , Coyle Vicky M. , Jithesh Puthen V. , Proutski Irina , Carson Gail , Gordon Michael A. , Lenz Heinz-Josef D. , Van Schaeybroeck Sandra , Longley Daniel B. , Johnston Patrick G.
Published: April 2023

PDF file - 63K, unsupervised top 10 positive and negative correlated genes - SN38 basal.
Supplementary Table 4 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Authors: Allen Wendy L. , Stevenson Leanne , Coyle Vicky M. , Jithesh Puthen V. , Proutski Irina , Carson Gail , Gordon Michael A. , Lenz Heinz-Josef D. , Van Schaeybroeck Sandra , Longley Daniel B. , Johnston Patrick G.
Published: April 2023

PDF file - 62K, unsupervised top 10 positive and negative correlated genes - 5-FU inducible.
Supplementary Figure 6 from Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner
Authors: McCarthy Anna R. , Sachweh Marijke C.C. , Higgins Maureen , Campbell Johanna , Drummond Catherine J. , van Leeuwen Ingeborg M.M. , Pirrie Lisa , Ladds Marcus J.G.W. , Westwood Nicholas J. , Laín Sonia
Published: April 2023

PDF file - 139K, Cell lines with differing p53 status were treated with TSA for 6 hours.
Supplementary Table 2 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Authors: Allen Wendy L. , Stevenson Leanne , Coyle Vicky M. , Jithesh Puthen V. , Proutski Irina , Carson Gail , Gordon Michael A. , Lenz Heinz-Josef D. , Van Schaeybroeck Sandra , Longley Daniel B. , Johnston Patrick G.
Published: April 2023

PDF file - 62K, unsupervised top 10 positive and negative correlated genes - clinical.
Supplementary Figure 5 from Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner
Authors: McCarthy Anna R. , Sachweh Marijke C.C. , Higgins Maureen , Campbell Johanna , Drummond Catherine J. , van Leeuwen Ingeborg M.M. , Pirrie Lisa , Ladds Marcus J.G.W. , Westwood Nicholas J. , Laín Sonia
Published: April 2023

PDF file - 178K, Tenovin-D3 causes cell cycle arrest in SirT2 wild type but not knockout cells.
Supplementary Table 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Authors: Allen Wendy L. , Stevenson Leanne , Coyle Vicky M. , Jithesh Puthen V. , Proutski Irina , Carson Gail , Gordon Michael A. , Lenz Heinz-Josef D. , Van Schaeybroeck Sandra , Longley Daniel B. , Johnston Patrick G.
Published: April 2023

PDF file - 41K, QPCR validation.
Supplementary Figure 4 from Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner
Authors: McCarthy Anna R. , Sachweh Marijke C.C. , Higgins Maureen , Campbell Johanna , Drummond Catherine J. , van Leeuwen Ingeborg M.M. , Pirrie Lisa , Ladds Marcus J.G.W. , Westwood Nicholas J. , Laín Sonia
Published: April 2023

PDF file - 30K, Tenovin-6 and tenovin-D3 are poor inhibitors of HDAC8 and SirT3.
Supplementary Figure 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Authors: Allen Wendy L. , Stevenson Leanne , Coyle Vicky M. , Jithesh Puthen V. , Proutski Irina , Carson Gail , Gordon Michael A. , Lenz Heinz-Josef D. , Van Schaeybroeck Sandra , Longley Daniel B. , Johnston Patrick G.
Published: April 2023

PDF file - 32K, QPCR validations.
Supplementary Figure 2 from Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner
Authors: McCarthy Anna R. , Sachweh Marijke C.C. , Higgins Maureen , Campbell Johanna , Drummond Catherine J. , van Leeuwen Ingeborg M.M. , Pirrie Lisa , Ladds Marcus J.G.W. , Westwood Nicholas J. , Laín Sonia
Published: April 2023

PDF file - 38K, Inhibition of purified SirT1 and SirT2 by tenovin-D3 using FdL substrates at 15 μM.
Supplementary Table 2 from MLN0905, a Small-Molecule PLK1 Inhibitor, Induces Antitumor Responses in Human Models of Diffuse Large B-cell Lymphoma
Authors: Shi Judy Quiju , Lasky Kerri , Shinde Vaishali , Stringer Bradley , Qian Mark G. , Liao Debra , Liu Ray , Driscoll Denise , Nestor Michelle Tighe , Amidon Benjamin S. , Rao Youlan , Duffey Matt O. , Manfredi Mark G. , Vos Tricia J. , Amore Natalie D' , Hyer Marc L.
Published: April 2023

PDF file, 48KB, Plasma and OCI LY-19-Luc tumor pharmacokinetic parameters following a single oral dose of MLN0905 in CB-17 SCID mice.
Supplementary Table 1 from MLN0905, a Small-Molecule PLK1 Inhibitor, Induces Antitumor Responses in Human Models of Diffuse Large B-cell Lymphoma
Authors: Shi Judy Quiju , Lasky Kerri , Shinde Vaishali , Stringer Bradley , Qian Mark G. , Liao Debra , Liu Ray , Driscoll Denise , Nestor Michelle Tighe , Amidon Benjamin S. , Rao Youlan , Duffey Matt O. , Manfredi Mark G. , Vos Tricia J. , Amore Natalie D' , Hyer Marc L.
Published: April 2023

PDF file, 44KB, Evaluating cell viability in DLBCL cell lines following MLN0905 treatment.
Supplementary Figure Legend from MLN0905, a Small-Molecule PLK1 Inhibitor, Induces Antitumor Responses in Human Models of Diffuse Large B-cell Lymphoma
Authors: Shi Judy Quiju , Lasky Kerri , Shinde Vaishali , Stringer Bradley , Qian Mark G. , Liao Debra , Liu Ray , Driscoll Denise , Nestor Michelle Tighe , Amidon Benjamin S. , Rao Youlan , Duffey Matt O. , Manfredi Mark G. , Vos Tricia J. , Amore Natalie D' , Hyer Marc L.
Published: April 2023

PDF file, 59KB.
Supplementary Figure 4 from MLN0905, a Small-Molecule PLK1 Inhibitor, Induces Antitumor Responses in Human Models of Diffuse Large B-cell Lymphoma
Authors: Shi Judy Quiju , Lasky Kerri , Shinde Vaishali , Stringer Bradley , Qian Mark G. , Liao Debra , Liu Ray , Driscoll Denise , Nestor Michelle Tighe , Amidon Benjamin S. , Rao Youlan , Duffey Matt O. , Manfredi Mark G. , Vos Tricia J. , Amore Natalie D' , Hyer Marc L.
Published: April 2023

PDF file, 53KB, MLN0905 yields significant anti-tumor responses in mice bearing subcutaneous OCI LY-10 tumors.
Supplementary Figure 2 from MLN0905, a Small-Molecule PLK1 Inhibitor, Induces Antitumor Responses in Human Models of Diffuse Large B-cell Lymphoma
Authors: Shi Judy Quiju , Lasky Kerri , Shinde Vaishali , Stringer Bradley , Qian Mark G. , Liao Debra , Liu Ray , Driscoll Denise , Nestor Michelle Tighe , Amidon Benjamin S. , Rao Youlan , Duffey Matt O. , Manfredi Mark G. , Vos Tricia J. , Amore Natalie D' , Hyer Marc L.
Published: April 2023

PDF file, 43KB, Evaluating pHisH3 in OCI LY-19-Luc and OCI LY-10 cells following MLN0905 treatment.
Supplementary Figure 4 from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling
Authors: Thurn K. Ted , Thomas Scott , Raha Paromita , Qureshi Ian , Munster Pamela N.
Published: April 2023

PDF file, 285K, Proposed Model.
Supplementary Figure 1 from MLN0905, a Small-Molecule PLK1 Inhibitor, Induces Antitumor Responses in Human Models of Diffuse Large B-cell Lymphoma
Authors: Shi Judy Quiju , Lasky Kerri , Shinde Vaishali , Stringer Bradley , Qian Mark G. , Liao Debra , Liu Ray , Driscoll Denise , Nestor Michelle Tighe , Amidon Benjamin S. , Rao Youlan , Duffey Matt O. , Manfredi Mark G. , Vos Tricia J. , Amore Natalie D' , Hyer Marc L.
Published: April 2023

PDF file, 42KB, Pharmacokinetic profiles of plasma and OCI-LY19-Luc tumor tissue in mice treated with a single oral dose of MLN0905.
Supplementary Methods from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells
Authors: Chang De-Kuan , Sui Jianhua , Geng Shusheng , Muvaffak Asli , Bai Mei , Fuhlbrigge Robert C. , Lo Agnes , Yammanuru Anuradha , Hubbard Luke , Sheehan Jared , Campbell James J. , Zhu Quan , Kupper Thomas S. , Marasco Wayne A.
Published: April 2023

PDF file, 97K.
Supplementary Figure 5 from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells
Authors: Chang De-Kuan , Sui Jianhua , Geng Shusheng , Muvaffak Asli , Bai Mei , Fuhlbrigge Robert C. , Lo Agnes , Yammanuru Anuradha , Hubbard Luke , Sheehan Jared , Campbell James J. , Zhu Quan , Kupper Thomas S. , Marasco Wayne A.
Published: April 2023

PDF file, 51K, Anti-CCR4 antibodies abrogate the suppressive function of Tregs on Teff proliferation.
Supplementary Figure 4 from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells
Authors: Chang De-Kuan , Sui Jianhua , Geng Shusheng , Muvaffak Asli , Bai Mei , Fuhlbrigge Robert C. , Lo Agnes , Yammanuru Anuradha , Hubbard Luke , Sheehan Jared , Campbell James J. , Zhu Quan , Kupper Thomas S. , Marasco Wayne A.
Published: April 2023

PDF file, 51K, CDC activity of h1567, 1-44 and 2-3 variants against Mac-1 cells.
Supplementary Figure 3 from TAK-960, a Novel, Orally Available, Selective Inhibitor of Polo-Like Kinase 1, Shows Broad-spectrum Preclinical Antitumor Activity in Multiple Dosing Regimens
Authors: Hikichi Yuichi , Honda Kohei , Hikami Kouki , Miyashita Hitoshi , Kaieda Isao , Murai Saomi , Uchiyama Noriko , Hasegawa Maki , Kawamoto Tomohiro , Sato Takashi , Ichikawa Takashi , Cao Sheldon , Nie Zhe , Zhang Lilly , Yang Johnny , Kuida Keisuke , Kupperman Erik
Published: April 2023

PDF file - 130K, Anti-tumor activity of TAK-960 in MV4-11luc disseminated leukemia model.
Supplementary Figure 2 from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells
Authors: Chang De-Kuan , Sui Jianhua , Geng Shusheng , Muvaffak Asli , Bai Mei , Fuhlbrigge Robert C. , Lo Agnes , Yammanuru Anuradha , Hubbard Luke , Sheehan Jared , Campbell James J. , Zhu Quan , Kupper Thomas S. , Marasco Wayne A.
Published: April 2023

PDF file, 456K, Affinity maturation of humanized anti-CCR4 mAb1567.
Supplementary Figure 2 from TAK-960, a Novel, Orally Available, Selective Inhibitor of Polo-Like Kinase 1, Shows Broad-spectrum Preclinical Antitumor Activity in Multiple Dosing Regimens
Authors: Hikichi Yuichi , Honda Kohei , Hikami Kouki , Miyashita Hitoshi , Kaieda Isao , Murai Saomi , Uchiyama Noriko , Hasegawa Maki , Kawamoto Tomohiro , Sato Takashi , Ichikawa Takashi , Cao Sheldon , Nie Zhe , Zhang Lilly , Yang Johnny , Kuida Keisuke , Kupperman Erik
Published: April 2023

PDF file - 144K, Comparison of dosing regimens.
Supplementary Figure 1 from TAK-960, a Novel, Orally Available, Selective Inhibitor of Polo-Like Kinase 1, Shows Broad-spectrum Preclinical Antitumor Activity in Multiple Dosing Regimens
Authors: Hikichi Yuichi , Honda Kohei , Hikami Kouki , Miyashita Hitoshi , Kaieda Isao , Murai Saomi , Uchiyama Noriko , Hasegawa Maki , Kawamoto Tomohiro , Sato Takashi , Ichikawa Takashi , Cao Sheldon , Nie Zhe , Zhang Lilly , Yang Johnny , Kuida Keisuke , Kupperman Erik
Published: April 2023

PDF file - 85K, Relationship between TP53 (A) or KRAS (B) gene status and TAK 960 concentration producing EC50 values. Each data point represents a mean concentration producing 50% efficacy (EC50) value for TAK 960 in an individual cell line.
Supplementary Table 2 from Evading Pgp Activity in Drug-Resistant Cancer Cells: A Structural and Functional Study of Antitubulin Furan Metotica Compounds
Authors: Nguyen Tam Luong , Cera Maria Rosaria , Pinto Andrea , Lo Presti Leonardo , Hamel Ernest , Conti Paola , Gussio Rick , De Wulf Peter
Published: April 2023

PDF file, 51KB, Selected geometrical parameters of the short H���O intermolecular contacts for S-A8.
Supplementary Figure 1 from PARP1 Is Overexpressed in Nasopharyngeal Carcinoma and Its Inhibition Enhances Radiotherapy
Authors: Chow Jeremy P.H. , Man Wing Yu , Mao Mao , Chen Han , Cheung Florence , Nicholls John , Tsao Sai Wah , Li Lung Maria , Poon Randy Y.C.
Published: April 2023

PDF - 117KB, Body weight of mice
Supplementary Table 1 from Evading Pgp Activity in Drug-Resistant Cancer Cells: A Structural and Functional Study of Antitubulin Furan Metotica Compounds
Authors: Nguyen Tam Luong , Cera Maria Rosaria , Pinto Andrea , Lo Presti Leonardo , Hamel Ernest , Conti Paola , Gussio Rick , De Wulf Peter
Published: April 2023

PDF file, 72KB, Selected Bond Lengths (�) and Torsion Angles (deg) for S-A8.
Supplementary Figure Legend from Evading Pgp Activity in Drug-Resistant Cancer Cells: A Structural and Functional Study of Antitubulin Furan Metotica Compounds
Authors: Nguyen Tam Luong , Cera Maria Rosaria , Pinto Andrea , Lo Presti Leonardo , Hamel Ernest , Conti Paola , Gussio Rick , De Wulf Peter
Published: April 2023

PDF file, 97KB, Legends to the Supplementary Figures.
Supplementary Figure 1 from Evading Pgp Activity in Drug-Resistant Cancer Cells: A Structural and Functional Study of Antitubulin Furan Metotica Compounds
Authors: Nguyen Tam Luong , Cera Maria Rosaria , Pinto Andrea , Lo Presti Leonardo , Hamel Ernest , Conti Paola , Gussio Rick , De Wulf Peter
Published: April 2023

PDF file, 152KB, 1H NMR spectrum of (�)-Boc-A8. The lower panel details the spectrum between 6.4 and 2.4 ppm.
Supplementary Figure 5 from Targeting FoxM1 Effectively Retards p53-Null Lymphoma and Sarcoma
Authors: Wang Zebin , Zheng Yu , Park Hyun Jung , Li Jing , Carr Janai R. , Chen Yi-ju , Kiefer Megan M. , Kopanja Dragana , Bagchi Srilata , Tyner Angela L. , Raychaudhuri Pradip
Published: April 2023

PDF file - 52 KB, A, Representative picture of tumor mass in kidney. B, Tumor mass of kidneys dissected from PBS, MUT and WT peptide treated SCID mice. Representative two mice from each group are shown.
Supplementary Figure 4 from Targeting FoxM1 Effectively Retards p53-Null Lymphoma and Sarcoma
Authors: Wang Zebin , Zheng Yu , Park Hyun Jung , Li Jing , Carr Janai R. , Chen Yi-ju , Kiefer Megan M. , Kopanja Dragana , Bagchi Srilata , Tyner Angela L. , Raychaudhuri Pradip
Published: April 2023

PDF file - 103 KB, A, CreERT2 Foxm1 fl/fl and p53 -/- thymic lymphoma cell viability at 0h and 24 hours following non, 5�M of ARF 26-44 peptide, 5�M of ARF 37-44 peptide or PBS treatment. B, Foci formation of CreERT2 Foxm1 fl/fl and p53 -/- sarcoma cells following PBS, 25�M of ARF 27-44 peptide, or ARF 36-44 peptide treatment. C, Cleaved-caspase 3 staining of CreERT2 Foxm1 fl/fl and p53 -/- sarcoma cells 24 hours after 25�M of ARF 27-44 peptide treatment.
Supplementary Figure 3 from Targeting FoxM1 Effectively Retards p53-Null Lymphoma and Sarcoma
Authors: Wang Zebin , Zheng Yu , Park Hyun Jung , Li Jing , Carr Janai R. , Chen Yi-ju , Kiefer Megan M. , Kopanja Dragana , Bagchi Srilata , Tyner Angela L. , Raychaudhuri Pradip
Published: April 2023

PDF file - 216 KB, A, FoxM1 IHC staining of 5 micron allografted sarcoma tissue of control group. B, tamoxifen treated group. C, thymic lymphoma control group. D, thymic lymphoma tamoxifen group. E-F and I-J, Representative TUNEL and DAPI staining of tumor sections from the subcutaneously inoculated CreERT2 Foxm1 fl/fl and p53 -/- sarcoma after tamoxifen or control treatment are shown. G-H and K-L, Representative TUNEL and DAPI staining of tumor sections from the subcutaneously inoculated CreERT2 Foxm1 fl/fl and p53 -/- thymic lymphoma after tamoxifen or control treatment are shown. M, quantification of number of positive cleaved-caspase 3 (Asp175) cells per field of thymic lymphoma is shown. N, quantification of number of positive cleaved-PARP (Asp214) cells per field of thymic lymphoma is shown.
Supplementary Figure 1 from Targeting FoxM1 Effectively Retards p53-Null Lymphoma and Sarcoma
Authors: Wang Zebin , Zheng Yu , Park Hyun Jung , Li Jing , Carr Janai R. , Chen Yi-ju , Kiefer Megan M. , Kopanja Dragana , Bagchi Srilata , Tyner Angela L. , Raychaudhuri Pradip
Published: April 2023

PDF file - 93 KB, Box plot of FoxM1 mRNA expression level in tumors harboring mutations in p53 or having wild type p53. Datasets were extracted from ONCOMINE database. P values were calculated using Student's t test.
Supplementary Figure 1 from Mechanism of Drug Efficacy Within the EGF Receptor Revealed by Microsecond Molecular Dynamics Simulation
Authors: Wan Shunzhou , Wright David W. , Coveney Peter V.
Published: April 2023

PDF file - 182K, Time evolution of the first two principal components (PCs) and the relative non-overlapped volumes for gefitinib
Supplementary Figure 1 from MET Activation Mediates Resistance to Lapatinib Inhibition of HER2-Amplified Gastric Cancer Cells
Authors: Chen Chin-Tung , Kim Hyaehwan , Liska David , Gao Sizhi , Christensen James G. , Weiser Martin R.
Published: April 2023

PDF file - 54K
Supplementary Figure 2 from Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF-κB Pathways
Authors: Wu Xinqi , Li Jingjing , Zhu Meijun , Fletcher Jonathan A. , Hodi F. Stephen
Published: April 2023

PDF file, 98KB, AEB071 inhibited GSK3β phosphorylation in UM cells.
Supplementary Figure 3 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
Authors: Li Rui , Hu Zhongliang , Sun Shi-Yong , Chen Zhuo G. , Owonikoko Taofeek K. , Sica Gabriel L. , Ramalingam Suresh S. , Curran Walter J. , Khuri Fadlo R. , Deng Xingming
Published: April 2023

PDF file, 78K, Treatment of mice with human lung cancer HCC827/ER xenografts using a combination of erlotinib and niclosamide results in a long term tumor-free survival.
Supplementary Figure 1 from Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF-κB Pathways
Authors: Wu Xinqi , Li Jingjing , Zhu Meijun , Fletcher Jonathan A. , Hodi F. Stephen
Published: April 2023

PDF file, 41KB, AEB071 selectively reduced viability of GNAQ mutated UM cells.
Supplementary Figure Legends from Targeted Degradation of KRAS by an Engineered Ubiquitin Ligase Suppresses Pancreatic Cancer Cell Growth In Vitro and In Vivo
Authors: Ma Yihui , Gu Yumei , Zhang Qiang , Han Yongqing , Yu Shuangni , Lu Zhaohui , Chen Jie
Published: April 2023

PDF file - 62KB
Supplementary Materials and Methods from SK-216, an Inhibitor of Plasminogen Activator Inhibitor-1, Limits Tumor Progression and Angiogenesis
Authors: Masuda Takeshi , Hattori Noboru , Senoo Tadashi , Akita Shin , Ishikawa Nobuhisa , Fujitaka Kazunori , Haruta Yoshinori , Murai Hiroshi , Kohno Nobuoki
Published: April 2023

PDF - 51KB, Immunohistochemical staining of PAI-1
Supplementary Figure 1 from Targeted Degradation of KRAS by an Engineered Ubiquitin Ligase Suppresses Pancreatic Cancer Cell Growth In Vitro and In Vivo
Authors: Ma Yihui , Gu Yumei , Zhang Qiang , Han Yongqing , Yu Shuangni , Lu Zhaohui , Chen Jie
Published: April 2023

PDF file - 637KB, The RC-U degrades KRAS, HRAS and NRAS.
Supplementary Figure Legends from SK-216, an Inhibitor of Plasminogen Activator Inhibitor-1, Limits Tumor Progression and Angiogenesis
Authors: Masuda Takeshi , Hattori Noboru , Senoo Tadashi , Akita Shin , Ishikawa Nobuhisa , Fujitaka Kazunori , Haruta Yoshinori , Murai Hiroshi , Kohno Nobuoki
Published: April 2023

PDF - 41KB, Supplementary Figure Legends for Supplementary Figures 1 through 3
Supplementary Figure Legend and Methods from Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism
Authors: Westendorf Aron F. , Woods Julie A. , Korpis Katharina , Farrer Nicola J. , Salassa Luca , Robinson Kim , Appleyard Virginia , Murray Karen , Grünert Renate , Thompson Alastair M. , Sadler Peter J. , Bednarski Patrick J.
Published: April 2023

PDF file, 105KB.
Supplementary Figure 5 from Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism
Authors: Westendorf Aron F. , Woods Julie A. , Korpis Katharina , Farrer Nicola J. , Salassa Luca , Robinson Kim , Appleyard Virginia , Murray Karen , Grünert Renate , Thompson Alastair M. , Sadler Peter J. , Bednarski Patrick J.
Published: April 2023

PDF file, 73KB, Calculated and experimental absorption spectra of 3.
Supplementary Figure Legends and Methods from Glycolysis Inhibition Sensitizes Non–Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation
Authors: Kim Sun Mi , Yun Mi Ran , Hong Yun Kyoung , Solca Flavio , Kim Joo-Hang , Kim Hyun-Jung , Cho Byoung Chul
Published: April 2023

PDF file, 163K.
Supplementary Figure 3 from Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism
Authors: Westendorf Aron F. , Woods Julie A. , Korpis Katharina , Farrer Nicola J. , Salassa Luca , Robinson Kim , Appleyard Virginia , Murray Karen , Grünert Renate , Thompson Alastair M. , Sadler Peter J. , Bednarski Patrick J.
Published: April 2023

PDF file, 105KB, 14N{1H} NMR spectra of unlabelled and 15N-NH3 labelled 3.
Supplementary Figure Legend from Targeting TRAIL Death Receptor 4 with Trivalent DR4 Atrimer Complexes
Authors: Allen Joshua E. , Ferrini Roger , Dicker David T. , Batzer Glenda , Chen Elise , Oltean Daniela I. , Lin Bing , Renshaw Mark W. , Kretz-Rommel Anke , El-Deiry Wafik S.
Published: April 2023

PDF file, 55K.
Supplementary Figure 7 from Targeting TRAIL Death Receptor 4 with Trivalent DR4 Atrimer Complexes
Authors: Allen Joshua E. , Ferrini Roger , Dicker David T. , Batzer Glenda , Chen Elise , Oltean Daniela I. , Lin Bing , Renshaw Mark W. , Kretz-Rommel Anke , El-Deiry Wafik S.
Published: April 2023

PDF file, 63K, Combining DR4 Atrimer� complexes with TRAIL. Sub-G1 content in HCT116 cells treated with 1G2 (50 ng/mL) or TRAIL (25 ng/mL) for 24 hours (n=2).
Supplementary Figure 5 from Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background
Authors: Davies Barry R. , Greenwood Hannah , Dudley Phillippa , Crafter Claire , Yu De-Hua , Zhang Jingchuan , Li Jing , Gao Beirong , Ji Qunsheng , Maynard Juliana , Ricketts Sally-Ann , Cross Darren , Cosulich Sabina , Chresta Christine C. , Page Ken , Yates James , Lane Clare , Watson Rebecca , Luke Richard , Ogilvie Donald , Pass Martin
Published: April 2023

PDF file - 88K, Quantification of cleaved caspase 3 activity in HCC-1187 xenografts following chronic dosing with 5 mg/kg once weekly docetaxel (taxotere), 150 mg/kg bid AZD5363, or a combination of these two agents.
Supplementary Figure 4 from Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background
Authors: Davies Barry R. , Greenwood Hannah , Dudley Phillippa , Crafter Claire , Yu De-Hua , Zhang Jingchuan , Li Jing , Gao Beirong , Ji Qunsheng , Maynard Juliana , Ricketts Sally-Ann , Cross Darren , Cosulich Sabina , Chresta Christine C. , Page Ken , Yates James , Lane Clare , Watson Rebecca , Luke Richard , Ogilvie Donald , Pass Martin
Published: April 2023

PDF file - 139K, AZD5363 has a predominantly anti-proliferative mechanism of action but induces cell death in BT474c, LNCaP and PC346C-Flut1 cells in vitro, and in BT474c xenografts following a high, intermittent dosing schedule in vivo.
Supplementary Figure 4 from Targeting TRAIL Death Receptor 4 with Trivalent DR4 Atrimer Complexes
Authors: Allen Joshua E. , Ferrini Roger , Dicker David T. , Batzer Glenda , Chen Elise , Oltean Daniela I. , Lin Bing , Renshaw Mark W. , Kretz-Rommel Anke , El-Deiry Wafik S.
Published: April 2023

PDF file, 53K, TRAIL-receptor expression in SW620 and HCT15 cell lines. Western blot analysis of TRAIL receptors in SW620 and HCT15 cells.
Supplementary Figure 3 from Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background
Authors: Davies Barry R. , Greenwood Hannah , Dudley Phillippa , Crafter Claire , Yu De-Hua , Zhang Jingchuan , Li Jing , Gao Beirong , Ji Qunsheng , Maynard Juliana , Ricketts Sally-Ann , Cross Darren , Cosulich Sabina , Chresta Christine C. , Page Ken , Yates James , Lane Clare , Watson Rebecca , Luke Richard , Ogilvie Donald , Pass Martin
Published: April 2023

PDF file - 84K, Correlation of AZD5363 activity in cell lines from different tumor types with RAS, PIK3CA and PTEN status.
Supplementary Figure 2 from Targeting TRAIL Death Receptor 4 with Trivalent DR4 Atrimer Complexes
Authors: Allen Joshua E. , Ferrini Roger , Dicker David T. , Batzer Glenda , Chen Elise , Oltean Daniela I. , Lin Bing , Renshaw Mark W. , Kretz-Rommel Anke , El-Deiry Wafik S.
Published: April 2023

PDF file, 157K, Representative example of screening affinity matured Atrimer� complexes. Single point cytotoxicity assays (A) we performed with 293 PEAK supernatants at 1:2 and 1:10 dilution using the Vialight Plus kit and compared to previously identified agonists. DR4 ELISA (B) was performed concurrently with the same supernatants diluted 1:20 and also compared to previously identified binders.
Supplementary Figure 1 from Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background
Authors: Davies Barry R. , Greenwood Hannah , Dudley Phillippa , Crafter Claire , Yu De-Hua , Zhang Jingchuan , Li Jing , Gao Beirong , Ji Qunsheng , Maynard Juliana , Ricketts Sally-Ann , Cross Darren , Cosulich Sabina , Chresta Christine C. , Page Ken , Yates James , Lane Clare , Watson Rebecca , Luke Richard , Ogilvie Donald , Pass Martin
Published: April 2023

PDF file - 117K, AZD5363 inhibits S6 phosphorylation in TSC1 -/-, TSC2 low-expressing RT4 bladder cancer cells.
Supplementary Figure 1 from Targeting TRAIL Death Receptor 4 with Trivalent DR4 Atrimer Complexes
Authors: Allen Joshua E. , Ferrini Roger , Dicker David T. , Batzer Glenda , Chen Elise , Oltean Daniela I. , Lin Bing , Renshaw Mark W. , Kretz-Rommel Anke , El-Deiry Wafik S.
Published: April 2023

PDF file, 80K, Schematic representation of different library designs for primary and affinity matured selections. The native sequence of the tetranectin loop regions is shown at the top. Alterations in the primary and affinity maturation libraries are shown below where an x indicates a position that was randomized in each library.
Supplementary Figure Legend from Evidence for the Ubiquitin Protease UBP43 as an Antineoplastic Target
Authors: Guo Yongli , Chinyengetere Fadzai , Dolinko Andrey V. , Lopez-Aguiar Alexandra , Lu Yun , Galimberti Fabrizio , Ma Tian , Feng Qing , Sekula David , Freemantle Sarah J. , Andrew Angeline S. , Memoli Vincent , Dmitrovsky Ethan
Published: April 2023

PDF file, 65K.
Supplementary Materials, Tables 1-2, Figure Legends 1-8 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Authors: Maira Sauveur-Michel , Pecchi Sabina , Huang Alan , Burger Matthew , Knapp Mark , Sterker Dario , Schnell Christian , Guthy Daniel , Nagel Tobi , Wiesmann Marion , Brachmann Saskia , Fritsch Christine , Dorsch Marion , Chène Patrick , Shoemaker Kevin , De Pover Alain , Menezes Daniel , Martiny-Baron Georg , Fabbro Doriano , Wilson Christopher J. , Schlegel Robert , Hofmann Francesco , García-Echeverría Carlos , Sellers William R. , Voliva Charles F.
Published: April 2023

PDF file - 180K
Supplementary Figure 7 from Evidence for the Ubiquitin Protease UBP43 as an Antineoplastic Target
Authors: Guo Yongli , Chinyengetere Fadzai , Dolinko Andrey V. , Lopez-Aguiar Alexandra , Lu Yun , Galimberti Fabrizio , Ma Tian , Feng Qing , Sekula David , Freemantle Sarah J. , Andrew Angeline S. , Memoli Vincent , Dmitrovsky Ethan
Published: April 2023

PDF file, 88K, Model of UBP43 action in tumors and how inhibition of UBP43 activity represents a new therapeutic target.
Supplementary Figure 7 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Authors: Maira Sauveur-Michel , Pecchi Sabina , Huang Alan , Burger Matthew , Knapp Mark , Sterker Dario , Schnell Christian , Guthy Daniel , Nagel Tobi , Wiesmann Marion , Brachmann Saskia , Fritsch Christine , Dorsch Marion , Chène Patrick , Shoemaker Kevin , De Pover Alain , Menezes Daniel , Martiny-Baron Georg , Fabbro Doriano , Wilson Christopher J. , Schlegel Robert , Hofmann Francesco , García-Echeverría Carlos , Sellers William R. , Voliva Charles F.
Published: April 2023

PDF file - 579K
Supplementary Figure 5 from Evidence for the Ubiquitin Protease UBP43 as an Antineoplastic Target
Authors: Guo Yongli , Chinyengetere Fadzai , Dolinko Andrey V. , Lopez-Aguiar Alexandra , Lu Yun , Galimberti Fabrizio , Ma Tian , Feng Qing , Sekula David , Freemantle Sarah J. , Andrew Angeline S. , Memoli Vincent , Dmitrovsky Ethan
Published: April 2023

PDF file, 166K, Repression of UBP43 mRNA inhibits in vivo and in vitro growth of ED1 lung cancer cells.
Supplementary Figure 6 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Authors: Maira Sauveur-Michel , Pecchi Sabina , Huang Alan , Burger Matthew , Knapp Mark , Sterker Dario , Schnell Christian , Guthy Daniel , Nagel Tobi , Wiesmann Marion , Brachmann Saskia , Fritsch Christine , Dorsch Marion , Chène Patrick , Shoemaker Kevin , De Pover Alain , Menezes Daniel , Martiny-Baron Georg , Fabbro Doriano , Wilson Christopher J. , Schlegel Robert , Hofmann Francesco , García-Echeverría Carlos , Sellers William R. , Voliva Charles F.
Published: April 2023

PDF file - 504K
Supplementary Figure 4 from Evidence for the Ubiquitin Protease UBP43 as an Antineoplastic Target
Authors: Guo Yongli , Chinyengetere Fadzai , Dolinko Andrey V. , Lopez-Aguiar Alexandra , Lu Yun , Galimberti Fabrizio , Ma Tian , Feng Qing , Sekula David , Freemantle Sarah J. , Andrew Angeline S. , Memoli Vincent , Dmitrovsky Ethan
Published: April 2023

PDF file, 75K, Deregulation of UBP43 affects immortalized bronchial epithelial cell growth, apoptosis and cyclin D1 levels.
Supplementary Figure 5 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Authors: Maira Sauveur-Michel , Pecchi Sabina , Huang Alan , Burger Matthew , Knapp Mark , Sterker Dario , Schnell Christian , Guthy Daniel , Nagel Tobi , Wiesmann Marion , Brachmann Saskia , Fritsch Christine , Dorsch Marion , Chène Patrick , Shoemaker Kevin , De Pover Alain , Menezes Daniel , Martiny-Baron Georg , Fabbro Doriano , Wilson Christopher J. , Schlegel Robert , Hofmann Francesco , García-Echeverría Carlos , Sellers William R. , Voliva Charles F.
Published: April 2023

PDF file - 532K
Supplementary Figure 3 from Evidence for the Ubiquitin Protease UBP43 as an Antineoplastic Target
Authors: Guo Yongli , Chinyengetere Fadzai , Dolinko Andrey V. , Lopez-Aguiar Alexandra , Lu Yun , Galimberti Fabrizio , Ma Tian , Feng Qing , Sekula David , Freemantle Sarah J. , Andrew Angeline S. , Memoli Vincent , Dmitrovsky Ethan
Published: April 2023

PDF file, 677K, The siRNA-mediated repression of UBP43 induced apoptosis which is partially reversed by overexpressing cyclin D1 levels.
Supplementary Figure 4 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Authors: Maira Sauveur-Michel , Pecchi Sabina , Huang Alan , Burger Matthew , Knapp Mark , Sterker Dario , Schnell Christian , Guthy Daniel , Nagel Tobi , Wiesmann Marion , Brachmann Saskia , Fritsch Christine , Dorsch Marion , Chène Patrick , Shoemaker Kevin , De Pover Alain , Menezes Daniel , Martiny-Baron Georg , Fabbro Doriano , Wilson Christopher J. , Schlegel Robert , Hofmann Francesco , García-Echeverría Carlos , Sellers William R. , Voliva Charles F.
Published: April 2023

PDF file - 766K
Supplementary Figure 2 from Evidence for the Ubiquitin Protease UBP43 as an Antineoplastic Target
Authors: Guo Yongli , Chinyengetere Fadzai , Dolinko Andrey V. , Lopez-Aguiar Alexandra , Lu Yun , Galimberti Fabrizio , Ma Tian , Feng Qing , Sekula David , Freemantle Sarah J. , Andrew Angeline S. , Memoli Vincent , Dmitrovsky Ethan
Published: April 2023

PDF file, 90K, Repression of UBP43 mRNA levels reduces cyclin D1 protein, but not mRNA expression.
Supplementary Figure 1 from Evidence for the Ubiquitin Protease UBP43 as an Antineoplastic Target
Authors: Guo Yongli , Chinyengetere Fadzai , Dolinko Andrey V. , Lopez-Aguiar Alexandra , Lu Yun , Galimberti Fabrizio , Ma Tian , Feng Qing , Sekula David , Freemantle Sarah J. , Andrew Angeline S. , Memoli Vincent , Dmitrovsky Ethan
Published: April 2023

PDF file, 76K, Reduction of UBP43 induces apoptosis and decreases cyclin D1 levels in ED-1L lung cancer cells.
Supplementary Figure 2 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Authors: Maira Sauveur-Michel , Pecchi Sabina , Huang Alan , Burger Matthew , Knapp Mark , Sterker Dario , Schnell Christian , Guthy Daniel , Nagel Tobi , Wiesmann Marion , Brachmann Saskia , Fritsch Christine , Dorsch Marion , Chène Patrick , Shoemaker Kevin , De Pover Alain , Menezes Daniel , Martiny-Baron Georg , Fabbro Doriano , Wilson Christopher J. , Schlegel Robert , Hofmann Francesco , García-Echeverría Carlos , Sellers William R. , Voliva Charles F.
Published: April 2023

PDF file - 253K
Supplementary Table 1 from Targeting Subcellular Localization through the Polo-Box Domain: Non-ATP Competitive Inhibitors Recapitulate a PLK1 Phenotype
Authors: McInnes Campbell , Estes Kara , Baxter Merissa , Yang Zhengguan , Farag Doaa Boshra , Johnston Paul , Lazo John S. , Wang Jianjun , Wyatt Michael D.
Published: April 2023

PDF file - 36K, HPLC and MS data
Supplementary Methods from Targeting Subcellular Localization through the Polo-Box Domain: Non-ATP Competitive Inhibitors Recapitulate a PLK1 Phenotype
Authors: McInnes Campbell , Estes Kara , Baxter Merissa , Yang Zhengguan , Farag Doaa Boshra , Johnston Paul , Lazo John S. , Wang Jianjun , Wyatt Michael D.
Published: April 2023

PDF file - 81K
Supplementary Figure Legends 1-2 from Targeting Subcellular Localization through the Polo-Box Domain: Non-ATP Competitive Inhibitors Recapitulate a PLK1 Phenotype
Authors: McInnes Campbell , Estes Kara , Baxter Merissa , Yang Zhengguan , Farag Doaa Boshra , Johnston Paul , Lazo John S. , Wang Jianjun , Wyatt Michael D.
Published: April 2023

PDF file - 28K
Supplementary Figure 2 from Targeting Subcellular Localization through the Polo-Box Domain: Non-ATP Competitive Inhibitors Recapitulate a PLK1 Phenotype
Authors: McInnes Campbell , Estes Kara , Baxter Merissa , Yang Zhengguan , Farag Doaa Boshra , Johnston Paul , Lazo John S. , Wang Jianjun , Wyatt Michael D.
Published: April 2023

PDF file - 571K, Scatter plots for Apoptosis/necrosis data
Supplementary Figure 2 from First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer
Authors: Brizuela Leyre , Ader Isabelle , Mazerolles Catherine , Bocquet Magalie , Malavaud Bernard , Cuvillier Olivier
Published: April 2023

PDF file, 107K, The modulation of S1P content in C4-2B prostate cancer cells alters sensitivity to irradiation.
Supplementary Figure 1 from First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer
Authors: Brizuela Leyre , Ader Isabelle , Mazerolles Catherine , Bocquet Magalie , Malavaud Bernard , Cuvillier Olivier
Published: April 2023

PDF file, 129K, PC-3 overexpressing-SPL cell lines exhibit a lower rate of cell viability associated with enhanced basal apoptosis.
Supplementary Table 1 from Contrary Regulation of Bladder Cancer Cell Proliferation and Invasion by Dexamethasone-Mediated Glucocorticoid Receptor Signals
Authors: Zheng Yichun , Izumi Koji , Li Yi , Ishiguro Hitoshi , Miyamoto Hiroshi
Published: April 2023

PDF file - 75K, Summary of antibodies used in the western blotting and IHC
Supplementary Figure Legend from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Authors: Gowda Raghavendra , Madhunapantula SubbaRao V. , Desai Dhimant , Amin Shantu , Robertson Gavin P.
Published: April 2023

PDF file - 57K
Supplementary Figure Legend from Contrary Regulation of Bladder Cancer Cell Proliferation and Invasion by Dexamethasone-Mediated Glucocorticoid Receptor Signals
Authors: Zheng Yichun , Izumi Koji , Li Yi , Ishiguro Hitoshi , Miyamoto Hiroshi
Published: April 2023

PDF file - 67K
Supplementary Figure 2 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Authors: Gowda Raghavendra , Madhunapantula SubbaRao V. , Desai Dhimant , Amin Shantu , Robertson Gavin P.
Published: April 2023

PDF file - 104K, Selenocoxib-1-GSH inhibits the generation of ROS
Supplementary Figure 1 from Contrary Regulation of Bladder Cancer Cell Proliferation and Invasion by Dexamethasone-Mediated Glucocorticoid Receptor Signals
Authors: Zheng Yichun , Izumi Koji , Li Yi , Ishiguro Hitoshi , Miyamoto Hiroshi
Published: April 2023

PDF file - 5939K, The expression of GR in human BC. A, GR mRNA expression was analyzed in UMUC3, TCC-SUP, J82, and 5637 cells by RT-PCR, and transcripts (163 bp) were separated on an agarose gel. PCR products derived from GAPDH mRNA (71 bp) served as an internal control. B, Cell extracts from UMUC3, TCC-SUP, J82, and 5637 were analyzed on western blotting, using an antibody to GR (95 kDa, with a second band at 90 kDa). β-Actin protein (43 kDa) served as an internal control. C, Immunohistochemistry (IHC) of GR in bladder TMA, including benign urothelium, primary urothelial carcinoma, and lymph node (LN) metastasis. The Kaplan-Meier analysis was performed to assess progression-free survival in patients with BC, according to the levels of GR expression. Comparison was made by log-rank test. Tumor progression was defined as development of local recurrence or metastatic tumor.
Supplementary Figure 1, Table 1 from Induction of Vascular Endothelial Growth Factor Secretion by Childhood Acute Lymphoblastic Leukemia Cells via the FLT-3 Signaling Pathway
Authors: Markovic Ana , MacKenzie Karen L. , Lock Richard B.
Published: April 2023

PDF file - 283K
Supplementary Figure Legend from The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of p53-Mutated Multiple Myeloma Cells
Authors: Landau Heather J. , McNeely Samuel C. , Nair Jayasree S. , Comenzo Raymond L. , Asai Takashi , Friedman Hillel , Jhanwar Suresh C. , Nimer Stephen D. , Schwartz Gary K.
Published: April 2023

PDF file, 52KB.
Supplementary Figure 2 from The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of p53-Mutated Multiple Myeloma Cells
Authors: Landau Heather J. , McNeely Samuel C. , Nair Jayasree S. , Comenzo Raymond L. , Asai Takashi , Friedman Hillel , Jhanwar Suresh C. , Nimer Stephen D. , Schwartz Gary K.
Published: April 2023

PDF file, 145KB, AZD7762 does not enhance PARP and caspase 3 cleavage in combination with bortezomib. Immunoblot analysis in KMS-12-PE cells after 24 and 48 h bortezomib +/- AZD7762 as indicated.
Supplementary Figure 1 from The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of p53-Mutated Multiple Myeloma Cells
Authors: Landau Heather J. , McNeely Samuel C. , Nair Jayasree S. , Comenzo Raymond L. , Asai Takashi , Friedman Hillel , Jhanwar Suresh C. , Nimer Stephen D. , Schwartz Gary K.
Published: April 2023

PDF file, 824KB, AZD7762 abrogates cell cycle arrest and induces mitotic catastrophe. Immunoblot analysis in RPMI-8226 cells after 24 and 48 h (A) bendamustine or melphalan (B) +/- AZD7762 as indicated.
Supplementary Figure 3 from Inhibition of Monocarboxylate Transporter 2 Induces Senescence-Associated Mitochondrial Dysfunction and Suppresses Progression of Colorectal Malignancies In Vivo
Authors: Lee Inkyoung , Lee Sook-Ja , Kang Won Ki , Park Chaehwa
Published: April 2023

PDF file, 52K, Effect of MCT1 knockdown on mitochondrial mass.
Supplementary Figure 2 from Inhibition of Monocarboxylate Transporter 2 Induces Senescence-Associated Mitochondrial Dysfunction and Suppresses Progression of Colorectal Malignancies In Vivo
Authors: Lee Inkyoung , Lee Sook-Ja , Kang Won Ki , Park Chaehwa
Published: April 2023

PDF file, 61K, Effect of MCT1 knockdown on ROS accumulation.
Supplementary Figure 1 from Inhibition of Monocarboxylate Transporter 2 Induces Senescence-Associated Mitochondrial Dysfunction and Suppresses Progression of Colorectal Malignancies In Vivo
Authors: Lee Inkyoung , Lee Sook-Ja , Kang Won Ki , Park Chaehwa
Published: April 2023

PDF file, 336K, Differential effects of siMCT1 vs siMCT2 on the growth of colon cancer cells.
Supplementary Methods from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Authors: Cao Yu , Marks James D. , Huang Qian , Rudnick Stephen I. , Xiong Chiyi , Hittelman Walter N. , Wen Xiaoxia , Marks John W. , Cheung Lawrence H. , Boland Kim , Li Chun , Adams Gregory P. , Rosenblum Michael G.
Published: April 2023

PDF file - 155KB
Supplementary Table 1 from Targeting KRAS-Mutant Non–Small Cell Lung Cancer with the Hsp90 Inhibitor Ganetespib
Authors: Acquaviva Jaime , Smith Donald L. , Sang Jim , Friedland Julie C. , He Suqin , Sequeira Manuel , Zhang Chaohua , Wada Yumiko , Proia David A.
Published: April 2023

PDF file - 79K, Fold-changes in protein expression following ganetespib treatment in KRAS mutant NSCLC lines using reverse phase protein array analysis
Supplementary Figure 6 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Authors: Cao Yu , Marks James D. , Huang Qian , Rudnick Stephen I. , Xiong Chiyi , Hittelman Walter N. , Wen Xiaoxia , Marks John W. , Cheung Lawrence H. , Boland Kim , Li Chun , Adams Gregory P. , Rosenblum Michael G.
Published: April 2023

PDF file - 1215KB, Enzymatic activities of AST and LDH in the serum of mice with or without tumors, treated with rGel, MH3-B1/rGel or B1D3/rGel.
Supplementary Figure 4 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Authors: Cao Yu , Marks James D. , Huang Qian , Rudnick Stephen I. , Xiong Chiyi , Hittelman Walter N. , Wen Xiaoxia , Marks John W. , Cheung Lawrence H. , Boland Kim , Li Chun , Adams Gregory P. , Rosenblum Michael G.
Published: April 2023

PDF file - 2744KB, Ex vivo optical imaging of tumor and other organs after 24 and 72h postinjection of IRDye800-MH3-B1/rGel or IRDye800-B1D3/rGel using the Xenogen IVIS imaging system.
Supplementary Table 7 from DNA Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer
Authors: Chen Min , Shabashvili Daniel , Nawab Akbar , Yang Sherry X. , Dyer Lisa M. , Brown Kevin D. , Hollingshead Melinda , Hunter Kent W. , Kaye Frederic J. , Hochwald Steven N. , Marquez Victor E. , Steeg Patricia , Zajac-Kaye Maria
Published: April 2023

PDF file - 235K, mRNA expression levels in normal mammary glands, mammary tumors and tumors from zebularine treated mice.
Supplementary Figure 2 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Authors: Cao Yu , Marks James D. , Huang Qian , Rudnick Stephen I. , Xiong Chiyi , Hittelman Walter N. , Wen Xiaoxia , Marks John W. , Cheung Lawrence H. , Boland Kim , Li Chun , Adams Gregory P. , Rosenblum Michael G.
Published: April 2023

PDF file - 1631KB, Competitive cytotoxicity of the scFv/rGel in the presence of free Her2/neu ECD.
Supplementary Figure 1 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Authors: Cao Yu , Marks James D. , Huang Qian , Rudnick Stephen I. , Xiong Chiyi , Hittelman Walter N. , Wen Xiaoxia , Marks John W. , Cheung Lawrence H. , Boland Kim , Li Chun , Adams Gregory P. , Rosenblum Michael G.
Published: April 2023

PDF file - 4112KB, Competitive internalization assay of 20nM immunotoxins with different concentration of the Her2/neu ECD on BT474 M1 cells.
Supplementary Table 3 from DNA Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer
Authors: Chen Min , Shabashvili Daniel , Nawab Akbar , Yang Sherry X. , Dyer Lisa M. , Brown Kevin D. , Hollingshead Melinda , Hunter Kent W. , Kaye Frederic J. , Hochwald Steven N. , Marquez Victor E. , Steeg Patricia , Zajac-Kaye Maria
Published: April 2023

PDF file - 262K, Differentially up-regulated genes (>1.5-fold differences; P < 0.05) from mammary tumors of the PyMT transgenic mice exposed to zebularine for 23 days.