bluuebunny/crossref_metadata_2025 huggingface dataset:
Teleworking, task sharing, and work life balance: A gender issue? Theoretical approach
Authors:   Human Resources and Responsible Organizations Warocque School of Business and Economics University of Mons, Mons, Belgium, Dupont Claire , Giuliano Romina ,   Human Resources and Responsible Organizations Warocque School of Business and Economics University of Mons, Mons, Belgium, Godfroid Cécile ,   Management and Organization Studies Warocque School of Business and Economics University of Mons, Mons, Belgium
Published: November 2023

Aim/purpose – The impact of teleworking on the work-life balance is still not clear. Since women are the ones who tend to assume most of the domestic tasks, our paper aims to determine, in gender terms and with a theoretical approach, how the effects of teleworking may affect the division of domestic tasks and the reconciliation of the pri- vate and professional spheres. Design/methodology/approach – This paper is based on a literature review and focuses on theoretical perspectives. Findings – On the one hand, the flexibility offered by teleworking during the health crisis may have enabled women to achieve a better work-life balance by offering them the possibility of not having to stop working despite the family responsibilities they had to assume. On the other, the unequal distribution of unpaid domestic work, which has continued and even increased during the crisis, has forced many women to quit their jobs. Research implications/limitations – The health crisis has shown that as long as tele- working is not organized in a way challenging the assumption of the home as a female environment, the office will stay a male environment with gender inequalities always prevailing between home and work. Originality/value/contribution – This paper contributes to the literature on teleworking by highlighting that generalizing teleworking without considering gender aspects may be harmful to female workers. Such a finding is important in the actual context of the de- velopment of hybrid organizations. Keywords: Teleworking, gender, repartition of domestic tasks, work-life balance. JEL Classification: O15, J16.
Fanfiction as a New Social Media, or For What Reason the Youth Write and Read Non-Professional Literature
Authors: Kashina M. A. , Pedchenko A. A.
Published: November 2023

Fanfiction is the literary work of fans who use the plots lines and characters from their favorite work — “canon”. It arose with the advent of the Internet, because the Internet is the place where such works can be published and discussed. Assessments of this phenomenon are very ambiguous: from low-grade graphomania to a school of literary excellence. In any case, fan fiction is an important element of popular / convergent culture, including Russian, which has a noticeable socializing influence on its participants.

   The purpose of the study is to describe the specifics of fanfiction as a new social media in modern Russian speaking community.

   Objectives: 1) Characterize the readership of Russian-language fanfiction; 2) Determine the motivation of fan fiction readers; 3) Describe the nature of reader preferences; 4) Highlight the functions of fanfiction as social media and their implementation by Russian readers.

   Theoretical framework: G. Jenkins’ theory of convergent culture and M. McLuhan’s broad approach to understanding media.

   Empirical base — online survey of 1007 respondents, secondary analysis of fanfiction research data.

   Results. The main readers of fan fiction are young middle-class women living in cities and big cities; they study or work in the field of education, science, art and IT. The functions that fanfiction performs correlate with the functions of social media: first of all, entertainment, recreation and leisure, secondly, new emotions and new impressions. Combined with the opportunity to communicate with like-minded people, share your opinion or publish your own texts, fanfiction becomes a space in which each individual user plays important role in the concrete fanfic’s history. It reveals Fanfiction’s convergent nature. Directions for further research: studying the influence of stereotypical ideas about fanfiction on its development, analyzing the reasons for the ambivalent attitude of readers and authors of fan fiction towards cruelty, finding out the reasons for the gender homogeneous composition of the online fanfiction community.
Forecasting the Directions of the State Policy of the Region on the Basis of Cluster Analysis of Indicators of Socio-Economic Development of Its Municipalities
Authors: Borodin S. N.
Published: November 2023

Assessment of the prospects for the development of the region is an important task for both economic science and public authorities.

   The purpose of this article is to develop an algorithm for assessing the prospects for the development of the region, which would allow identifying the most problematic areas and competitive advantages of territorial development in order to determine the most important areas of budget expenditures in the context of municipalities in the region.

   The research uses the concept of sustainable development and the theory of clusters as a methodological basis. Cluster analysis by the Ward method and k-means were used as research methods. As a forecasting method, the most effective among the methods was used: least squares, exponential smoothing, moving average for 3 and 5 years. Separately, the demographic forecast for each municipality separately was used to predict the population. As a result of the conducted research, groups of municipalities of the region differentiated by the level of development have been identified, for which the main problem areas have been formulated, the leveling of which should be addressed by the state policy of the region. The advantage of the proposed approach is that it identifies and predicts the problems of socio-economic development of the region, which may be hidden in the medium-term forecast of the socio-economic region. In this research, such problems were identified in many municipalities of the Leningrad region in the field of housing construction, demography and economics. The article may be useful to public authorities when forming a strategy for socio-economic development.
Assessing Interregional Differentiation in China
Authors: Yai Liu , Vertakova Yu. V.
Published: November 2023

The article is devoted to the problems of differentiation in the development of regions. Interregional disproportions in development can be traced in many countries, including China and Russia. The topic of assessing inter-regional differentiation and improving the territorial regional policy is relevant. The authors postulate the idea that in order to reduce inter-regionaldifferentiation, targeted measures of state economic policy should be applied, in particular, this should be included in regional strategic documents.

   The purpose of the study is to assess inter-regional differentiation in China based on comparative analysis and the index method (calculation of the Theil index, standard deviation, coefficient of variation).

   Research methods: analysis and synthesis, comparative and economic-statistical analysis.

   The object of the study is macroeconomic indicators (GRP, GRP per capita, disposable income per capita) in the context of the provinces of the PRC for the period from 2001 to 2020.

   The article analyzes the dynamics of the level of differentiation of China’s regional development and identifies the advantages and disadvantages of the implemented regional policies to reduce the asymmetry of regions. Particular attention is paid to the fragmentation and lack of coordination of existing regional policies in China. The necessity of transforming the current regional policy and building a new unified regional policy is revealed.
Pola Komunikasi Komunitas Katapel (Studi Etnografi Komunikasi Komunitas Katapel dalam Merevitalisasi Kearifan Lokal Menjadi Ekonomi Kreatif)
Authors: Ardiansyah Ardiansyah , Atmodjo Juwono Tri
Published: November 2023

Abstrak. Kebutuhan, keinginan dan cara pemesanan katapel menentukan proses komunikasi khas selama proses transaksi di workshop pengrajin atau basecamp klub. Cara pemesanan, suasana pemesanan dan pelayanan melibatkan tidak tutur dan peristiwa komunikasi sesuai dengan peran masing-masing personal. Tindak tutur pengrajin katapel-pelanggan di worksop pengrajin atau basecamp klub sebagai pokok masalah pada penelitian ini. Metode penelitian yang digunakan yaitu metode etnografi komunikasi dengan kerangka kerja Dell Hymes. Pengumpulan data yang digunakan yaitu melalui observasi participan, wawancara mendalam dan dokumentasi. Hasil penelitian komunikasi yang khas dalam mengkomunikasikan jenis katapel, perlengkapan katapel,bahan, bentuk, cara memainkan dan jenis layanan yang diberikan penjual kepada pembeli sebagai pola komunikasi komunitas katapel.
AKTIVITAS CYBER PUBLIC RELATIONS ELMIKA HIJRAH MELALUI MEDIA SOSIAL
Authors: Hani Rafika , Risanti Yuliani Dewi
Published: November 2023

This research focused on the implementation of Cyber Public Relations activities through the use of social media. Cyber Public Relations activities are increasingly being carried out by Public Relations practitioners in line with the increasing internet users in Indonesia. The purpose of this study was to determine how the campaign activities carried out by Syar'i Muslim clothing companies through the implementation of Cyber Public Relations which focused on the use of social media through the stages of strategic communication planning. This research uses a qualitative case study method with data collection through observation, documentation and in-depth interviews with the owners and employees of the companies that are the research objects. The results showed that in campaign activities, the object under study had determined the values in Hijrah to be communicated in the implementation of Cyber Public Relations. In the communication media selection stage, the company uses social media Facebook, Twitter and finally focuses on using Instagram. As for measuring the effectiveness of the campaign, it has not been done optimally because it is only seen from the number of followers, likes, comments and shares obtained from each content uploaded on social media.
DIGITAL SOCIETY AND PANDEMICS: AN OVERVIEW
Authors: Modili Cyril
Published: November 2023

Life becomes a new normal during pandemics for everyone. Life becomes increasingly digital as we incorporate them into every aspect of our lives, most notably shopping and education. During this period, technology and pandemic are a natural match. When pandemics strike, information and communication technology add value to society. The term "digital society" refers to a society that makes use of digital technologies on a regular basis (Che Noh et.al., 2017; Hintz, et.al., 2017; Katzenbach and Bachle, 2019). The purpose of this study is to provide an overview of how the digital society functions daily, particularly during pandemics. Additionally, this review article discusses the concepts and characteristics of a digital society, including the usage of digital technology tools, the evolution of tools and digital technology utilised prior to and during pandemics, and the changes in lifestyles in a digital society.
Mesenchymal stem cell therapy modulates macrophage dynamics in ARDS-associated liver injury in rats
Authors:   I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, Redko Olesya , Dovgalyuk Alina , Kramar Solomiia , Ohinska Nataliia , Nebesna Zoia , Korda Mykhaylo
Published: November 2023

Acute Respiratory Distress Syndrome (ARDS) is a life-threatening pulmonary condition characterized by severe hypoxemia and respiratory failure. Beyond its devastating impact on the lungs, ARDS often triggers systemic responses affecting vital organs throughout the body. One such organ commonly affected is the liver, which experiences various degrees of injury during the course of ARDS. Pathophysiological changes in liver during ARDS, particularly polarization of Kupffer cells during the disease and its treatment, have drawn increasing attention. Purpose. To explore the macrophage transformation in liver injury associated with ARDS and investigate the potential of mesenchymal stem cell (MSC) therapy as a means to modulate macrophage responses and mitigate liver injury. Materials and methods. 72 mature male Wistar rats were randomly allocated to nine experimental groups as follows: the control group, groups assessed at 3 days, 7 days, and 28 days following intranasal LPS administration, groups that received 24 hours of LPS followed by 2 days of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), groups exposed to 4 days of LPS and 3 days of hUC-MSCs, groups subjected to 14 days of LPS and 14 days of hUC-MSCs, groups treated with LPS 21 days and 7 days with hUC-MSCs injection, and a control group assessed 3 days after hUC-MSCs injection. For the administration of hUC-MSCs, intraperitoneal injections were performed at a dose of 1∙106 cells/kg body weight. Immunohistochemistry was employed to analyze macrophage subpopulations in liver tissues. Animal experiments adhered to ethical guidelines. Results. Early ARDS stages showed increased M1 macrophages, indicating pro-inflammatory responses, while later stages showed M2 macrophage activation, suggestive of anti-inflammatory and tissue repair roles. MSC administration facilitated the transition from M1 to M2 macrophages, promoting an anti-inflammatory milieu. Conclusions. MSCs demonstrate the potential to modulate macrophage polarization into M2 anti-inflammatory phenotype. Such findings reflect one of the mechanisms of MSC action which holds practical significance for future ARDS therapies, aiming to mitigate excessive inflammation and enhance tissue repair.
Crowding-out: Government & private investment analysis
Authors: Trebicka Brunela , Gjini Altin , Fortuzi Shkelqim
Published: November 2023

This study examines the crowding-out effect in Albania from 2000 to 2022, specifically investigating the relationship between government investment (GI) and private investment (PI). Using time series data for gross domestic product (GDP), GI, PI, and real interest rates (RI), we applied the Johansen cointegration test and vector error correction model (VECM) to analyse the long-run and short-run relationships among these variables. Our results indicate a significant long-run correlation between GI and PI, suggesting that increased government investment in Albania leads to reduced private investment, demonstrating the crowding-out effect. Moreover, we observe a positive connection emerges between real interest rates and private investment. Consistent with prior research, Funashima and Ohtsuka (2019) identified both crowding-out and crowding-in effects in Japan, echoing our findings. Similarly, Bedhiye and Singh (2022) noted a negative correlation between government and private investment in developing economies. These findings have critical implications for policymakers, underscoring the potential negative consequences of government investment on private investment and economic growth. Effective policy implementation necessitates a delicate equilibrium between government investment and its potential adverse effects. In summary, this study offers valuable insights into government-private investment interactions in Albania, highlighting the crowding-out effect and the influence of real interest rates. These insights contribute to informed policymaking for sustainable economic growth.
Heart rate fragmentation: A novel analytic approach to early allostatic load detection among healthy adults
Authors: Chan Jennifer , Andersen Judith
Published: November 2023

The current study explores an emerging cardiac metric, heart rate
fragmentation (HRF), as a novel biomarker for allostatic load (AL). HRF
may better address the limitations of existing cardiac biomarkers (e.g.,
confounds and interpretation consistency) in applied research settings,
with nonclinical samples. The study’s objectives were: 1) can HRF
represent response to psychological stress and 2) can resting HRF be
used as a measure of predicting subclinical mental health symptoms. One
hundred and fifty-six (n = 156; 75% female) undergraduate students were
fitted with a chest band to monitor cardiovascular activity, and
completed online demographic and psychosocial surveys in which they were
grouped as healthy or displaying probable mental health symptoms (pMH; n
= 94, 60.25%) based on respective inventory thresholds for depression,
anxiety, and posttraumatic stress disorder. Cardiovascular activity was
measured capturing the three R’s of cardiac vagal control: a resting
baseline, a reactive acute stressor task, and a paced breathing
recovery. Results supported the first hypothesis, in that that HRF
significantly differentiated between each RRR condition (p <
0.001). While healthy and pMH individuals did not significantly differ
within individual conditions, exploratory analyses revealed healthy
individuals displayed significantly larger change in HRF reactivity
between conditions (p’s < 0.001) in comparison to pMH, which
displayed a more blunted pattern. Overall, this study establishes
associations between HRF and mental health, and serves as a promising
new biomarker that may identify AL in samples that may be otherwise
considered “healthy”, while addressing the limitations of prior
biomarkers in non-clinical studies.
Thermodynamic Bounds of Terrestrial Water-Energy Coupling and Resiliency in Global Ecosystems
Authors: Mishra Debasish , Sehgal Vinit , Mohanty Binayak P
Published: November 2023

Increasing climatic variability has resulted in an unprecedented surge
in extreme events, pressing global ecosystems towards systematic
breakdown. Yet, the resilience of the soil-vegetation-atmosphere (SVA)
system to revert to its natural state indicates the existence of
energetic barriers forbidding systems from tipping. Observational and
theoretical constraints limit our understanding of these energetic
barriers which are crucial for assessing ecosystem sensitivity to
atmospheric perturbations. We provide a novel coherent theory on the
dissipative energy barriers (𝛥e) which decides the resilience potential
of an ecosystem. These barriers are manifestation of lower bounds of
entropy produced ( Σ *) for unit anomaly transference from soil moisture
(SM) to evapotranspiration (ET). Using remote sensing data, we compute
these global entropy bounds by introducing a new metric (Wasserstein
distance, dw) for SM-ET coupling. Quantifying these lower bounds from
SM-ET coupling, places terrestrial ecosystems in the hierarchy of
dissipative energy states spanning from forested regions to barren
lands. Furthermore, we show that the optimization of SM-ET coupling
translates to entanglement of water potential gradient (∆ω) between land
surface and atmospheric boundary layer, and the resulting memory
timescale or residence time (τ). This (τ.∆ω) entanglement propels
moisture-rich and moisture-deficit systems in complementary evolutionary
pathways in responding to imposed anomalies. As a result, we witness an
emergence of coupling-aridity tradeoff with temperate climates operating
as least efficient systems for unit SM to ET anomaly transfer. Physical
basis, and transferability across space and scale makes this theory a
potential benchmark for process improvement in the climate and earth
system models.
Assessing Motivational Biases in Brain and Behavior: Event-Related Potential and Response Time Concomitants of the Approach-Avoidance Task
Authors: Sege Christopher , Lopez James , Hellman Natalie , McTeague Lisa
Published: November 2023

The Approach-Avoidance Task (AAT) is designed to 1) measure the implicit
motivated action biases that are instantiated by emotional stimuli, and
2) assess the changes in such biases that drive psychiatric disorder. To
establish AAT sensitivity to emotional action bias at a neural level,
some work has measured event-related potential (ERP) correlates —
however, a lack of research with unpleasant, pleasant, and neutral
stimuli together and also a common focus on psychiatric disorder-matched
(rather than generally evocative) content limits foundational
conclusions that can be drawn. In current research, then, 38 subjects
completed an AAT where normative (rather than idiosyncratic) unpleasant,
pleasant, and neutral images were shown with a color border indicating
if a joystick should be rapidly pushed or pulled to decrease or increase
image size. Using generally arousing stimuli, response times (RTs) were
found to be faster on unpleasant push compared to unpleasant pull
trials, t(37)=2.4, p=.02, and 32-sensor electroencephalography (EEG)
also revealed that amplitude of a stimulus-response conflict-related ERP
– the N200 – was reduced on unpleasant compared to neutral push trials
and un-pleasant push compared to unpleasant pull trials, t(32)=5.5,
p<.001. In addition, preliminary exploration of individual
differences suggested that relevant variables of dimensional trait
anxiety, depression, and anxiety disorder treatment seeking status did
not impact RT- or N200-indicated emotional biases. Together, then,
findings are consistent with a neurobehavioral avoidance bias for
unpleasant stimuli while also suggesting a need to further test whether
selecting images for idiosyncratic relevance is critical to revealing
individual variations in emotional bias.
Fluvial biogeomorphological feedbacks from plant traits to the landscape: lessons from French rivers in line with A.M. Gurnell’s influential contribution
Authors: Corenblit Dov , Steiger Johannes
Published: November 2023

Research in fluvial biogeomorphology largely aims to promote our
understanding of the interactions between riparian vegetation and
fluvial morphodynamics within riverine ecosystems. Starting at the end
of last century, Angela M. Gurnell has made a major contribution to
fluvial geomorphology by considering, in addition to water flow and
sediment transport, explicitly riparian, and later also aquatic
vegetation and thus significantly promoted the fluvial
biogeomorphological approach from its beginnings until today. The
objective of the present paper is to present a set of studies and
results obtained over the last twenty years by the authors and many
collaborators, including Angela M. Gurnell, on a panel of French rivers:
Tech, Garonne, Isère and Allier Rivers. In particular, feedback
mechanisms between fluvial morphodynamics and riparian vegetation
dynamics were investigated directly in the field and also using high
resolution remote sensing at the scale of individual plants,
populations, communities and landscapes, as well as during
semi-controlled ex situ experiments at the scale of individual
plants. Collectively, the authors’ research conducted over the past 20
years contributed to elucidate some key aspects of the feedback dynamics
between the lowest and highest levels of the riparian ecosystem
organisation. This article presents and discusses those key aspects. The
gradually obtained results contributed to better understand and quantify
feedbacks between river morphodynamics and vegetation at nested
spatiotemporal scales, from plant species traits to the riverine
landscape. Furthermore, the biogeomorphological approach advocated for
more than twenty years now, has clearly helped to contribute to the
enlargement of the discipline of geomorphology to ecology as well as
evolutionary ecology, and to the development of a more integrative
vision to study earth surface processes.
FUTURE PROGNOSIS FOR CARDIOVASCULAR COMPLICATIONS ASSOCIATED WITH SARS-COV-2: A PHARMACOLOGICAL AND MOLECULAR PERSPECTIVE
Authors: R Anand Vijayakumar P , jha Aditya , P Ranjith S
Published: November 2023

Background: The severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19), which
is associated with cardiovascular problems and serious lung damage.
COVID-19 patients with comorbid conditions are at a significantly
elevated risk of increased morbidity and mortality.
Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine
2 (TMPRSS2) are the two key host contributing factors for the severity
and pathogenesis of COVID-19. The principal SARS-CoV-2 entrance
receptor, ACE2, is expressed equally in most organs and produces
cardio-protective vasodilators by physically degrading angiotensin II,
the main controller of the Renin-Angiotensin Aldosterone System.
However, treatment for cardiovascular disease (CVD) commonly involves
RAAS inhibitors, which may increase ACE2 expression. Objective:
To summarize the pharmacological molecular discoveries into the
processes of viral infection and its consequences for cardiovascular
disease and to offer suggestions for the practical management and
treatment of COVID-19-related cardiovascular injury. Methods:
This review focuses on the important considerations related to the
cardiovascular manifestations of COVID-19 and discusses the various
mechanisms of COVID-19 that contribute to its molecular and
pharmacological presentation of cardiovascular injury. Results:
The host-pathogen relationship began with ACE2’s attachment to the
S-protein and proceeded with TMPRSS2’s proteolytic cleavage of the viral
spike (S)-protein and ACE2. Currently discovered protein-protein
interactions explain the uniqueness of SARS-CoV-2 infection.
Conclusion: COVID-19 is associated with cardiovascular problems
and serious lung damage. ACE2 and TMPRSS2 are key host contributing
factors for the severity and pathogenesis of COVID-19. The molecular
discoveries into the processes of viral infection and its consequences
for cardiovascular disease provide important considerations for the
management and treatment of COVID-19-related cardiovascular injury.
Surveillance of seasonal influenza viruses during the COVID-19 pandemic in Tokyo, Japan, 2018--2023, a single-center study
Authors: Takahashi Hidenori , Nagamatsu Hiroki , Yamada Yuka , Toba Naoya , Toyama-Kousaka Mio , Ota Shinichiro , Morikawa Miwa , Shinoda Masahiro , Takano Syunsuke , Park Kayoung , Fukasawa Reiko , Yano Takahiko , Mineshita Masamichi , Shinkai Masaharu
Published: November 2023

Introduction: COVID-19 pandemic led to significant reductions in
influenza detection worldwide, making influenza trends challenging to
monitor. The number of influenza cases decreased significantly in Japan,
raising concerns about the potential risk of decreased immunity to
influenza in the population. Our single-center study aimed to
investigate influenza trends before and during the COVID-19 pandemic in
Tokyo, Japan. Materials and Methods: This cross-sectional study included
patients of all ages who visited Tokyo Shinagawa Hospital between April
1, 2018, and March 31, 2023. Influenza and COVID-19 tests were conducted
using Quick Navi-Flu2 and polymerase chain reaction (PCR). We analyzed
data from before and during the COVID-19 epidemic, based on patient
background, hospitalization, and deaths, collected from medical records.
Results: A total of 12,577 influenza tests were conducted, with
approximately 100 tests consistently performed each month even in the
influenza off-season. Throughout the observation period, 962 positive
cases were identified. However, no cases were observed for 27 months
between March 2020 and November 2022. Cases of influenza A were observed
again in December 2022, and cases of influenza B were observed again in
March 2023, similar to the influenza incidence reports from Tokyo. The
positivity rate during the 2022–2023 winter season was lower than
before the COVID-19 epidemic and decreased in elderly patients, with no
hospitalizations or deaths observed. Conclusion: This single-center
study provided actual trend data for influenza patients before and
during COVID-19 outbreaks in Tokyo, which could offer insights into the
potential impact and likelihood of influenza virus infection in Japan.
A new perspective on variation of voriconazole steady-state valley concentration in Chinese population: CYP2C19 DNA methylation
Authors: Hao Xu , Zhao Yinyu , Liu Boyu , Hu Lei , Liu Fang , Guo Nan , Nie Xiaoyan , Yu Feng , Huang Lin , Feng Yufei
Published: November 2023

Background: Voriconazoleis(VRC) often used in complex therapeutic
environments for the treatment and prevention of invasive fungal
infections. The steady-state valley concentration (Cminss) of VRC not
only varies between individuals, but also within individuals, which is
difficult to fully explain by pharmacogenomic theory. It is necessary to
propose a new perspective to explain the variation of voriconazole
steady-state valley concentration. Objectives: Based on the regulation
of ADME gene expression by DNA methylation, this study aimed to explore
the effect of CYP2C19 DNA methylation level on the VRC Cminss. Methods:
In this study, 116 concentration points were divided into low
concentration group (Cminss<1.0mg/L), standard concentration
group (Cminss =1.0-5.5mg/L) and high concentration group
(Cminss>5.5mg/L) according to Voriconazole Cmin standard
range of 1.0-5.5 mg/L. The effect of CYP2C19 DNA methylation was
highlighted by predisposition score matching to exclude other
confounding factors. Results: The CYP2C19 CpG25 methylation level was
different between low concentration group and standard concentration
group (p=0.047). There was no difference in the CYP2C19 DNA methylation
between the high concentration group and the standard concentration
group, but there were significant differences in CRP
(p<0.001), Alb (p=0.007) and T-BIL (p=0.024) between the high
concentration group and the standard concentration group. Conclusions:
The VRC Cminss in the low concentration group may be related to the
methylation degree of CYP2C19 CpG25 site, while the VRC Cminss in the
high concentration group may be unrelated to the methylation degree of
CYP2C19 but related to the levels of CRP, Alb and T-BIL.
Pyroglutamylation Modulates Electronic Properties and the Conformational Ensemble of the Amyloid β -Peptide
Authors: Lemkul Justin , Davidson Darcy S.
Published: November 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder that is
characterized by the formation of extracellular amyloid- β (A
β) plaques. The underlying cause of AD is unknown, however,
post-translational modifications (PTMs) of A β have been found in
AD patients and are thought to play a role in protein aggregation. One
such PTM is pyroglutamylation, which can occur at two sites in A
β, Glu3 and Glu11. This modification of A β involves the
truncation and charge-neutralization of N-terminal glutamate, causing A
β to become more hy- drophobic and prone to aggregation. The
molecular mech- anism by which the introduction of pyroglutamate (pE)
pro- motes aggregation has not been determined. To gain a greater
understanding of the role that charge neutralization and trun- cation of
the N-terminus plays on A β conformational sam- pling, we used
the Drude polarizable force field (FF) to per- form molecular dynamics
simulations on A β and A β and comparing their properties to previous
simulations of A β. The Drude polarizable FF
allows for a more accurate representation of electrostatic interactions,
therefore pro- viding novel insights into the role that charge plays in
pro- tein dynamics. Here, we report the parametrization of pE in the
Drude polarizable FF and the effect of pyroglutamyla- tion on A
β. We found that A β and A β alter the permanent and induced dipoles of the
peptide. Specifically, we found that A β
and A β have modification- specific
backbone and sidechain polarization response and perturbed solvation
properties that shift the A β conforma- tional ensemble.
Research on Identification Method of Abnormal Grounding Circulating Current in Single-Core AC Submarine Cable
Authors: Yuxin Yang , Yongli Zhu , Jinsong Wang , Yan Li
Published: November 2023

The grounding circulation current of sheath and armor of single-core AC
submarine cables is high during operation, which can easily cause
insulation damage and faults. Traditional methods that only monitor the
amplitude of grounding circulation current is difficult to detect
defects in the cables, so further research is needed on the mathematical
mechanism and detection methods of grounding circulation current. A
mathematical model for the capacitance and impedance coupling of a
single-core submarine cable was established, and the influence of
factors such as active power, length of armor stripping section, armor
resistivity, armor magnetic permeability and grounding resistance on the
grounding circulation current was analyzed. A method for identifying
abnormal grounding circulation current of submarine cables based on the
combination of amplitude and phase was proposed.
A high precision localization method for underwater targets incorporating direct path recognition and sound rays bending compensation
Authors: Cui Xuerong , Ji Meiqi , Li Juan , Jiang Bin , Li Lei , Li Shibao , Liu Jianhang
Published: November 2023

Underwater target localization technology plays a vital role in the
development and utilization of marine resources. Due to the multipath
effect in the hydroacoustic channel, the received signal is the
superposition of a series of direct and reflected acoustic paths, making
it challenging to accurately identify the direct path using existing
methods. To address this issue, this paper proposes a high-precision
direct path recognition method based on LightGBM, which utilizes the
amplitude, Time of Arrival (TOA), reception angle, and phase of the
received pulse as input features. Meanwhile, due to the propagation time
of acoustic waves from transmitter to receiver cannot be linearly
converted to a distance value, as in the case of radio ranging in air, a
method based on Effective Sound Velocity (ESV) is introduced to
compensate for the bending of sound rays. By utilizing the recognized
direct path delay value and the sound velocity value after compensating
for sound ray bending, we can calculate the precise position of
underwater targets. Experimental results validate the effectiveness of
the proposed method in significantly improving the accuracy of
underwater target localization.
Changes in daylength links latitudinal and seasonal trends in clutch size
Authors: Burgess Murry , Voss Margaret , Cooper Caren
Published: November 2023

Near ubiquitous reproductive trends across taxa follow a pattern in
which output increases with latitudes and decreases with calendar date.
Research grounded in life history theory provides separate ultimate
explanations for latitudinal and seasonal trends. Here we frame these
dual trends as a Simpson’s paradox and attempt to gain insights into
proximate cues that might account for both simultaneously. Using citizen
science data on Eastern bluebirds, we found highest support for a model
of clutch size based on change in day length at clutch initiation.
Describing reproductive trends based on non-biologically relevant
constructs of latitude and calendar date obscured links between
proximate and ultimate explanations. For birds, our findings are
consistent with an internal coincidence model of circadian rhythmicity
as a proximate control of clutch size. Other avian studies might benefit
from viewing clutch size as a circadian behavior of clutch initiation
and termination rather than a quantified trait.
Pristine and Doped Transition Metal oxides for Lithium Ion Batteries
Authors: Bhattacharyya A S , Kommu P
Published: November 2023

Mixed transition metal oxides with adjustable composition and structures are widely used in electro chemical cell applications such as lithium-ion batteries and supercapacitors their high theoretical capacity, high energy density, high cyclic durability, and environment friendliness compared to mono metal oxides. Different routes like sol gel, combustion, solvothermal, sonication, hydrothermal are used for their synthesis. This chapter gives an overview of some of the key MTMOs in different structural and forms like layer, core-shall, nanorods, nanosheets etc and in the forms of composites with materials like PANI, rGO, CNT, CNF etc
"Rapid Diagnosis of Dengue: A Crucial Tool in Global Healthcare"
Authors: Castillo Nicolás
Published: November 2023

This article explores the fundamental importance of implementing rapid tests in the diagnosis of dengue, emphasizing their essential role in early detection and efficient management of this mosquito-transmitted disease. These tests, based on the detection of viral antigens or specific antibodies, not only provide results in record time but also constitute a significant contribution to global healthcare. Rapid tests offer an immediate response, allowing timely medical intervention that can make a difference in the clinical course of the patient. Their ability to identify the virus in the early stages of infection is crucial, not only for individualized care but also for mitigating the spread of dengue at the community level. Moreover, by distinguishing between virus serotypes, these tests provide a more precise perspective for the application of therapeutic and preventive strategies. The accessibility and simplicity of rapid tests become key elements for their positive impact, especially in resource-limited settings. The swift availability of results not only accelerates clinical decision-making but also facilitates the collection of crucial epidemiological data. This information contributes to the strategic planning of public health authorities, enabling a coordinated and efficient response to dengue outbreaks and epidemics. The widespread adoption of rapid tests in dengue diagnosis emerges as a fundamental pillar in global healthcare. Their ability to provide rapid and accurate results, their role in early detection, and their contribution to efficient management make these tests an invaluable tool in the fight against this prevalent disease, redefining how we approach the diagnosis and treatment of dengue on a global scale.
Treatment of Vulvar Angiolymphoid Hyperplasia with Eosinophilia with Topical Corticosteroids
Authors: Fazil Jaber Nor , Krynitz Britta , Curman Philip
Published: November 2023

Abstract is missing (Short communication)
PERSPECTIVES AND SPECIFIC FEATURES OF THE USE OF COMPOSITE MATERIALS FOR STRENGTHENING OF DAMAGED REINFORCED CONCRETE STRUCTURES
Authors:   Lviv Polytechnic National University, Department of Highways and Bridges, Kopiika Nadiia , Blikharskyy Yaroslav ,   Lviv Polytechnic National University, Department of Highways and Bridges
Published: November 2023

The need for strengthening of existing structures has recently become topical. Composite materials due to their remarkable properties, possibility to adaptation to the design requirements and facilitation of restoration measures are widely used for strengthening. This article is focused on review of restoration approaches with the use of composite materials and specific features of their behavior under various impacts. Study includes analysis of recent studies in the area, identifying gaps of knowledge and perspectives for further research. The most relevant areas of research were distinguished including numerical finite element modelling for parametric analysis, deepening of understanding of composites` linearly elastic behavior, approaches to prevent delamination failure. Further thorough research in this area is strongly recommended to deepen the knowledge and maximize the efficiency of use of composite strengthening systems.
OVER-STABILIZED BITUMEN EMULSIONS MADE FROM EMULSIFIERS FOR SLOW-SETTING EMULSIONS
Authors:   Lviv Polytechnic National University, Department of Highways and Bridges, Bidos Volodymyr , Sidun Iurii ,   Lviv Polytechnic National University, Department of Highways and Bridges, Sobol Khrystyna ,   Lviv Polytechnic National University, Department of Highways and Bridges, Rybchynskyi Sergii ,   Lviv Polytechnic National University, Department of Highways and Bridges
Published: November 2023

Formulations of road over-stabilized cationic bitumen emulsions with orthophosphoric, sulfuric and hydrochloric acids and cationic emulsifiers for slowly disintegrating emulsions have been designed. The physical and mechanical properties of the manufactured over-stabilized bitumen emulsions and their breaking behavior were determined. It has been established that over-stabilised bitumen emulsions demonstrate good storage stability for 180 days. The obtained results of breaking behavior bitumen emulsions indicate that emulsions based on hydrochloric and sulfuric acid have a shorter fines mixing time and greater mixing stability with cement than emulsions based on orthophosphoric acid. For over-stabilized bitumen emulsions on orthophosphoric acid, the method according to DSTU EN 12848:2020 is not effective, due to the high reactivity of emulsions on orthophosphoric acid during interaction with portland cement.
THE HARVESTED RAINWATER AS A SOURCE OF NON-DRINKING WATER SUPPLY IN TYPICAL RESIDENTIAL MICRODISTRICTS OF UKRAINIAN CITIES
Authors:   Lviv Polytechnic National University, Department of Hydraulic and Water Engineering, Vovk Lesya , Orel Vadym ,   Lviv Polytechnic National University, Department of Hydraulic and Water Engineering, Tarkanii Anastasiia ,   Lviv Polytechnic National University, Department of Hydraulic and Water Engineering
Published: November 2023

Ukraine, facing water resource scarcity, finds it increasingly challenging to provide high-quality drinking water for both its population and industries, particularly in times of war. Harvested rainwater, among these sources, aligns well with water resource protection and management measures to counteract drinking water shortages. A literature review indicates that domestic needs in cities (flushing toilets, cleaning, and laundry) account for over 50% of drinking water demand, which could be supplemented by harvested rainwater. The estimated volume of harvested rainwater for a residential building in Odesa and Uzhgorod showed a drinking water saving to 15% and 36.5%, respectively. Similar calculations were carried out for residential microdistricts with high-rise buildings in these cities, showing a saving of drinking water due to the use of rainwater to 9% and 19%, respectively.
INJECTION OF CRACKS IN A RC BEAM WITH EPOXY RESIN USING THE GRAVITY FLOW METHOD
Authors:   Lviv Polytechnic National University, Department of Highways and Bridges, Klym Andrii , Blikharskyy Yaroslav ,   Lviv Polytechnic National University, Department of Highways and Bridges
Published: November 2023

The restoration of the load-bearing capacity of RC beams through crack injection is one of the most efficient and practical methods for executing repairs in the field of civil engineering. In the article, following an analysis of crack injection methods in RC structures, an economically viable method for injecting RC beams is proposed. The core approach of the proposed crack injection method involves the process of introducing epoxy resin into the crack, which occurs by gravity flow (without specialized equipment and pressure). The paper outlines a systematic process for preparing the crack in the RC beam for epoxy resin injection. The crack injection method was conducted comprehensively, including the restoration of the compressed concrete zone within the RC beam. The test results demonstrated the effectiveness of the crack injection method, as there were no new crack formations at the injection sites, and the load-bearing capacity of the RC beam was restored to 115%.
PEMBELAJARAN MATEMATIKA MENGGUNAKAN MEDIA JARING-JARING TIMBUL UNTUK MENINGKATKAN HASIL BELAJAR SISWA SEKOLAH DASAR
Authors: Nur Fahmi Jefri
Published: November 2023

the aims of this Classroom Action Research is to improve mathematics learning outcomes using a geometric net media media for 23 students of Grade V at Janten Public Elementary School. The method employed is Classroom Action Research, with data collection techniques involving student activity observation sheets and written tests. The collected data is analyzed using qualitative descriptive techniques. The results after implementing the network media in mathematics learning showed an increase in mathematics learning outcomes. Prior to the intervention, 13.04 percent of students achieved scores above the Minimum Mastery Criteria (KKM), which then increased to 86.94 percent of students achieving scores above the KKM. Keywords: mathematics learning outcomes; geometric net media
El control de convencionalidad y su aplicación en la justicia peruana
Authors: López Loarte Luis Leonardo
Published: November 2023

El presente artículo tuvo como objetivo analizar el control de convencionalidad como un mecanismo jurídico de nivel internacional creado por la Corte Interamericana de Derechos Humanos; sin embargo, en nuestra realidad jurídica la mayoría de jueces no aplican dicha herramienta internacional frente a una controversia judicial que tienen en sus despachos para una eficaz protección de los derechos fundamentales. Se analizaron cinco casos. Propone como método un análisis de la naturaleza, origen, características y formas de aplicación del control de convencionalidad y sobre todo de los factores que impiden que los jueces peruanos apliquen esta herramienta jurídica internacional en el sistema judicial peruano. Se presenta un conjunto de herramientas jurídicas de utilidad para los jueces y fiscales de todos los niveles a fin de que apliquen el control de convencionalidad en los casos en los que se vean amenazados los derechos fundamentales de la persona humana.
Canadian respiratory therapists who considered leaving their clinical position experienced elevated moral distress and adverse psychological and functional outcomes during the COVID-19 pandemic
Authors: D’Alessandro-Lowe Andrea M. , Ritchie Kimberly , Brown Andrea , Easterbrook Bethany , Xue Yuanxin , Pichtikova Mina , Altman Max , Beech Isaac , Millman Heather , Foster Fatima , Hassall Kelly , Levy Yarden , Streiner David L. , Hosseiny Fardous , Rodrigues Sara , Heber Alexandra , O’Connor Charlene , Schielke Hugo , Malain Ann , McCabe Randi E. , Lanius Ruth A. , McKinnon Margaret C.
Published: November 2023

Introduction

Respiratory therapists (RTs) faced morally distressing situations throughout the COVID-19 pandemic, including working with limited resources and facilitating video calls for families of dying patients. Moral distress is associated with a host of adverse psychological and functional outcomes (e.g. depression, anxiety, symptoms of posttraumatic stress disorder [PTSD] and functional impairment) and consideration of position departure. The purpose of this study was to understand the impact of moral distress and its associated psychological and functional outcomes on consideration to leave a clinical position among Canadian RTs during the COVID-19 pandemic.

Methods

Canadian RTs (N = 213) completed an online survey between February and June 2021. Basic demographic information (e.g. age, sex, gender) and psychometrically validated measures of moral distress, depression, anxiety, stress, PTSD, dissociation, functional impairment, resilience and adverse childhood experiences were collected.

Results

One in four RTs reported considering leaving their position. RTs considering leaving reported elevated levels of moral distress and adverse psychological and functional outcomes compared to RTs not considering leaving. Over half (54.5%) of those considering leaving scored above the cut-off for potential diagnosis of PTSD. Previous consideration to leave a position and having left a position in the past each significantly increased the odds of currently considering leaving, along with system-related moral distress and symptoms of PTSD, but the contribution of these latter factors was small.

Conclusion

Canadian RTs considering leaving their position reported elevated levels of distress and adverse psychological and functional outcomes, yet these individual-level factors appear unlikely to be the primary factors underlying RTs’ consideration to leave, because their effects were small. Further research is required to identify broader, organizational factors that may contribute to consideration of position departure among Canadian RTs.