bluuebunny/crossref_metadata_2025 huggingface dataset:
Monitoring and Achievement of Target Serum Urate Among Gout Patients Receiving Long‐Term Urate‐Lowering Therapy in the American College of Rheumatology RISE Registry
Authors: Hammam Nevin , Li Jing , Kay Julia , Izadi Zara , Yazdany Jinoos , Schmajuk Gabriela
Published: August 2022

Objective

The American College of Rheumatology's (ACR) 2020 guidelines for the management of gout recommend using a treat‐to‐target approach to lower serum urate (SU). Using the ACR's Rheumatology Informatics System for Effectiveness registry, we examined the use of a treat‐to‐target approach among gout patients receiving long‐term urate‐lowering therapy (ULT) and followed longitudinally by rheumatologists.

Methods

Included patients had one or more diagnoses for gout in 2018–2019 and continuous use of ULT for ≥12 months. We assessed the proportions of patients with SU monitoring and, among those tested, who achieved SU <6.0 mg/dl during the measurement year. Multilevel logistic regression adjusting for sociodemographics, comorbidities, region, and health care utilization was used to determine factors associated with SU monitoring and achievement of target SU.

Results

A total of 9,560 were included. The mean ± SD age was 67.2 ± 12.7 years, 73.5% of patients were male, and 32.3% were non‐White. Fifty‐six percent of patients had at least 1 SU recorded during the measurement year; among patients with at least 1 SU recorded, 74% achieved the SU target. In multivariate analyses, non‐White patients were slightly less likely to be tested or achieve a target SU.

Conclusion

Among gout patients receiving long‐term ULT followed longitudinally by rheumatologists, more than half had a documented SU, and among those tested, three‐quarters achieved the recommended SU target. Routine monitoring of SU is a first step toward improving quality of care for patients with gout.
Porphyrin‐Based Covalent Organic Framework for Imaging‐Guided Cancer Combinatorial Immuno‐Sonodynamic Therapy
Authors: Lu Zhixiang , Bai Shuang , Jiang Yonghe , Wu Shuaiying , Xu Dazhuang , Chen Yulun , Lan Yulu , An Yibo , Mao Jingsong , Liu Xuan , Liu Gang
Published: August 2022

The rational design of tumor microenvironment (TME)‐activated nanomedicine is driving a new direction in tumor immunology. Furthermore, the novel therapeutic mode of ultrasound‐triggered sonodynamic therapy (SDT) has been proven to specifically activate the immune response. Herein, a well‐defined covalent organic framework (COF) with sonosensitive properties is synthesized through experimental and theoretical verification, followed by the efficient loading of the toll‐like receptor agonist (Poly(I:C)) and in situ growth of paramagnetic transitional metallic oxide of manganese bioxide (MnO2). The MnO2‐Poly(I:C)@COF shell can reverse the reductive TME by consuming glutathione (GSH) to release Mn2+, simultaneously generating marked magnetic resonance imaging signals for real‐time guidance. Importantly, the MnO2 acts as an enzyme‐like nano‐catalyst to promote TME‐overexpressed hydrogen peroxide (H2O2) and produce oxygen, facilitating SDT‐induced reactive oxygen species production, and inducing immunogenic cell death, thereby boosting immune engine and triggering abundant neoantigen exposure. With the powerful assistance of immunological agents Mn2+ and Poly(I:C), the triggered immune engine is amplified by refueling the engine (stepping on the accelerator) to reduce the immunosuppressive state. Overall, this study improves the synthesis of multifunctional COF and expands its application. The developed nano‐sonosensitizer system provides a paradigm to enhance SDT‐based high‐performance multifunctional sonosensitizers, and this SDT‐mediated strong tumor‐suppressive efficiency and activated immune effect represent a promising combinatorial therapeutic strategy for cancer therapy.
Natural Dual‐Crosslinking Bioadhesive Hydrogel for Corneal Regeneration in Large‐Size Defects
Authors: Zhao Long , Shi Zhen , Sun Xiuli , Yu Yaoyao , Wang Xin , Wang Hongwei , Li Tan , Zhang Hengrui , Zhang Xiaoyu , Wang Fuyan , Qi Xia , Cao Rui , Xie Lixin , Zhou Qingjun , Shi Weiyun
Published: August 2022

Corneal injectable hydrogels represent a promising alternative to alleviate donor shortage and simplify traditional surgeries. However, most hydrogels focus on repairing focal corneal defects (≤3.5 mm) and leave many clinical requirements unmet. Herein, a novel ion‐activated bioadhesive hydrogel (IonBAH) is designed and its long‐term performance of repairing large corneal defects (6 mm) is evaluated in rabbits for 6 months. The IonBAH is a dual‐network hydrogel composed of natural corneal extracellular matrix and peptide‐modified alginate, which enables its desirable transparency and biocompatibility, tunable mechanics, and robust adhesion. Moreover, the IonBAH maintains the secretory phenotype of quiescent keratocytes, while preventing their myofibroblastic differentiation in vitro. Upon application in situ, it rapidly seals the 6 mm corneal defect and forms normal curvature through the coverage of a contact lens impregnated with calcium ions. During the 6 months follow‐up, the IonBAH promotes rapid regeneration of corneal epithelium, stroma, and nerves with restored transparency, equivalent to the outcome of donor corneal transplantation. In addition, the suitability of IonBAH as an adhesive and patch for various clinical requirements are also evaluated with a pleasing outcome. Collectively, IonBAH may provide a clinically applicable scaffold for corneal surgeries, especially in large defect repair.
Establishing Self‐Dopant Design Principles from Structure–Function Relationships in Self‐n‐Doped Perylene Diimide Organic Semiconductors
Authors: Powell Daniel , Zhang Xueqiao , Nwachukwu Chideraa I. , Miller Edwin J. , Hansen Kameron R. , Flannery Laura , Ogle Jonathan , Berzansky Alex , Labram John G. , Roberts Andrew G. , Whittaker‐Brooks Luisa
Published: August 2022

Self‐doping is a particular doping method that has been applied to a wide range of organic semiconductors. However, there is a lack of understanding regarding the relationship between dopant structure and function. A structurally diverse series of self‐n‐doped perylene diimides (PDIs) is investigated to study the impact of steric encumbrance, counterion selection, and dopant/PDI tether distance on functional parameters such as doping, stability, morphology, and charge‐carrier mobility. The studies show that self‐n‐doping is best enabled by the use of sterically encumbered ammoniums with short tethers and Lewis basic counterions. Additionally, water is found to inhibit doping, which concludes that thermal degradation is merely a phenomenological feature of certain dopants, and that residual solvent evaporation is the primary driver of thermally activated doping. In situ grazing‐incidence wide‐angle X‐ray scattering studies show that sample annealing increases the π–π stacking distance and shrinks grain boundaries for improved long‐range ordering. These features are then correlated to contactless carrier‐mobility measurements with time‐resolved microwave conductivity before and after thermal annealing. The collective relationships between structural features and functionality are finally used to establish explicit self‐n‐dopant design principles for the future design of materials with improved functionality.
Polyaniline‐Based Nanostructure Interface for Signal‐to‐Noise Ratio Enhancement in Potentiometric Enzyme‐Free Biosensors
Authors: Nishitani Shoichi , Man Youyuan , Noguchi Taiga , Sakata Toshiya
Published: August 2022

Reduction of nonspecific signals (noise) in electrochemical biosensors is important for the realization of enzyme‐free, point‐of‐care (POC) diagnostic devices. In this study, a simple biosensor interface that simultaneously realizes analyte signal enhancement and noise reduction to increase signal‐to‐noise ratio in a field‐effect transistor‐based potentiometric biosensor is proposed. As a proof‐of‐concept, a phytic‐acid‐doped self‐functionalized polyaniline (pAni)‐based nanostructure is designed. It is shown that the incorporation of gold nanoparticles in the nanostructure increases the signal intensity in serotonin sensing. Moreover, the phenylboronic acid moiety in the pAni backbone and porous nanostructure of the pAni nanostructure reduces the interfering noise generated by catecholamines and human serum albumin. It is believed that this study will contribute to the realization of versatile and multiplexed POC diagnostic devices in the future.
Fabrication of Electronics by Electrohydrodynamic Jet Printing
Authors: Zhou Haihua , Song Yanlin
Published: August 2022

Electrohydrodynamic jet (e‐jet) printing technology overcomes some limitations such as the viscosity and resolution of the traditional ink‐jet printing by breaking surface tension of the droplets with high voltage and the formation of Taylor cone. The technique is becoming more and more popular because it can be widely used in the fabrication of the conductive line of electronics, electrode, transistor, sensor, and other electronics as microelectrode, microlen, and heater. This review provides insight into the effect of the influence factors such as voltage, speed, nozzle, jetting ink characteristics, and the representative conductive materials of the ink as metal nanoparticles (NPs) and carbon materials, or organic conductive polymers on the fabrication of the different electronics by the e‐jet printing technology. Specially, the characteristics of different resultant electronics are compared and the possible mechanisms are analyzed. Finally, the challenge and development trend of the e‐jet printing technology are discussed, which will shed a light on the fabrication of the next‐generation flexible electronics with better performance.
Selectively Coupling Ru Single Atoms to PtNi Concavities for High‐Performance Methanol Oxidation via d‐Band Center Regulation
Authors: Kong Fanpeng , Liu Xiaozhi , Song Yajie , Qian Zhengyi , Li Junjie , Zhang Lei , Yin Geping , Wang Jiajun , Su Dong , Sun Xueliang
Published: August 2022

Single atom tailored metal nanoparticles represent a new type of catalysts. Herein, we demonstrate a single atom‐cavity coupling strategy to regulate performance of single atom tailored nano‐catalysts. Selective atomic layer deposition (ALD) was conducted to deposit Ru single atoms on the surface concavities of PtNi nanoparticles (Ru‐ca‐PtNi). Ru‐ca‐PtNi exhibits a record‐high activity for methanol oxidation reaction (MOR) with 2.01 A mg−1Pt. Also, Ru‐ca‐PtNi showcases a significant durability with only 16 % activity loss. Operando electrochemical Fourier transform infrared spectroscopy (FTIR) and theoretical calculations demonstrate Ru single atoms coupled to cavities accelerate the CO removal by regulating d‐band center position. Further, the high diffusion barrier of Ru single atoms in concavities accounts for excellent stability. The developed Ru‐ca‐PtNi via single atom‐cavity coupling opens an encouraging pathway to design highly efficient single atom‐based (electro)catalysts.
Theoretical study of the high intersystem spin crossing (ISC) ability of a series of iridium complexes with low efficiency roll‐off properties
Authors: Song Ming‐Xing , Zhang Hai‐Han , Liu Xu‐Hui , Ji Ye , Guo Xi‐Lian , Yang Jia‐Yu , Qin Zheng‐Kun , Bai Fu‐Quan , Zhang Hong‐Jie
Published: August 2022

A series of heteroleptic cyclometalated Ir(III) complexes for OLEDs application have been investigated theoretically to explore their electronic structures and spectroscopic properties. The geometries, electronic structures, lowest‐lying singlet absorptions, and triplet emissions of (pdbi)2Ir(acac), (F‐pdbi)2Ir(acac), (pdbi)2Ir(dpis), (F‐pdbi)2Ir(dpis), (pdbi)2Ir(tpip), and (F‐pdbi)2Ir(tpip) were investigated with density function theory (DFT) and time‐dependent density functional theory (TD‐DFT), where pdbi denotes 1‐(4‐fluorophenyl)‐5‐methyl‐3‐phenyl‐2,3‐dihydro‐1H‐1,3‐benzodiazole, acac denotes acetylacetonate, dpis denotes diphenylimidodisilicate, and tpip denotes tetraphenylimido‐diphosphinate. In addition, we analyzed the spin‐orbit coupling constant of these six complexes, and the results showed that the six complexes have a high ability of interlinear scampering. We hope this research can serve as a reference for practical experimental synthesis aspects.
Study on the coating material of hexamethylol melamine modified phenolic resin for casting filter
Authors: Tang Yaoji , Huang Renhe , Yuan Zhenfei
Published: August 2022

In this article, hexamethylol melamine (HMM) modified phenolic resin (PF) coating material was prepared by using thermoplastic PF wastewater. Using alcohol soluble PF, the thermoplastic PF wastewater (containing oxalic acid catalyst), methanol and HMM as raw materials, HMM was methyl etherified by oxalic acid and then modified PF was synthesized. By determination of carbon residue, thermogravimetric analysis (TGA) and differential scanning calorimetry, the influences on the heat resistance of modified PF by the composition of wastewater, composition of melamine formaldehyde (MF) resin, and composition of MF resin modified PF were analyzed. The results showed that the phenol content in wastewater had no effect on the heat resistance. The MF resin modified by HMM with the highest molar ratio of formaldehyde and melamine had the highest heat resistance. And the nitrogen content of the highest thermostable modified PF was 5 wt%. Additional curing agent was not required for HMM modified PF. The possible pyrolysis process was discussed. As a filter coating material, the heat resistance of HMM modified PF was better than that of PF cured with traditional urotropine (HMTA).
Stable nebulization and muco‐trapping properties of regdanvimab/IN‐006 support its development as a potent, dose‐saving inhaled therapy for COVID‐19
Authors: McSweeney Morgan D. , Stewart Ian , Richardson Zach , Kang Hyunah , Park Yoona , Kim Cheolmin , Tiruthani Karthik , Wolf Whitney , Schaefer Alison , Kumar Priya , Aurora Harendra , Hutchins Jeff , Cho Jong Moon , Hickey Anthony J. , Lee Soo Young , Lai Samuel K.
Published: August 2022

The respiratory tract represents the key target for antiviral delivery in early interventions to prevent severe COVID‐19. While neutralizing monoclonal antibodies (mAb) possess considerable efficacy, their current reliance on parenteral dosing necessitates very large doses and places a substantial burden on the healthcare system. In contrast, direct inhaled delivery of mAb therapeutics offers the convenience of self‐dosing at home, as well as much more efficient mAb delivery to the respiratory tract. Here, building on our previous discovery of Fc‐mucin interactions crosslinking viruses to mucins, we showed that regdanvimab, a potent neutralizing mAb already approved for COVID‐19 in several countries, can effectively trap SARS‐CoV‐2 virus‐like particles in fresh human airway mucus. IN‐006, a reformulation of regdanvimab, was stably nebulized across a wide range of concentrations, with no loss of activity and no formation of aggregates. Finally, nebulized delivery of IN‐006 resulted in 100‐fold greater mAb levels in the lungs of rats compared to serum, in marked contrast to intravenously dosed mAbs. These results not only support our current efforts to evaluate the safety and efficacy of IN‐006 in clinical trials, but more broadly substantiate nebulized delivery of human antiviral mAbs as a new paradigm in treating SARS‐CoV‐2 and other respiratory pathologies.
Definition and verification of novel metastasis and recurrence related signatures of ccRCC: A multicohort study
Authors: Jiang Aimin , Pang Qingyang , Gan Xinxin , Wang Anbang , Wu Zhenjie , Liu Bing , Luo Peng , Qu Le , Wang Linhui
Published: August 2022

Background

Cancer metastasis and recurrence remain major challenges in renal carcinoma patient management. There are limited biomarkers to predict the metastatic probability of renal cancer, especially in the early‐stage subgroup. Here, our study applied robust machine‐learning algorithms to identify metastatic and recurrence‐related signatures across multiple renal cancer cohorts, which reached high accuracy in both training and testing cohorts.

Methods

Clear cell renal cell carcinoma (ccRCC) patients with primary or metastatic site sequencing information from eight cohorts, including one out‐house cohort, were enrolled in this study. Three robust machine‐learning algorithms were applied to identify metastatic signatures. Then, two distinct metastatic‐related subtypes were identified and verified; matrix remodeling associated 5 (MXRA5), as a promising diagnostic and therapeutic target, was investigated in vivo and in vitro.

Results

We identified five stable metastasis‐related signatures (renin, integrin subunit beta‐like 1, MXRA5, mesenchyme homeobox 2, and anoctamin 3) from multicenter cohorts. Additionally, we verified the specificity and sensibility of these signatures in external and out‐house cohorts, which displayed a satisfactory consistency. According to these metastatic signatures, patients were grouped into two distinct and heterogeneous ccRCC subtypes named metastatic cancer subtype 1 (MTCS1) and type 2 (MTCS2). MTCS2 exhibited poorer clinical outcomes and metastatic tendencies than MTCS1. In addition, MTCS2 showed higher immune cell infiltration and immune signature expression but a lower response rate to immune blockade therapy than MTCS1. The MTCS2 subgroup was more sensitive to saracatinib, sunitinib, and several molecular targeted drugs. In addition, MTCS2 displayed a higher genome mutation burden and instability. Furthermore, we constructed a prognosis model based on subtype biomarkers, which performed well in training and validation cohorts. Finally, MXRA5, as a promising biomarker, significantly suppressed malignant ability, including the cell migration and proliferation of ccRCC cell lines in vitro and in vivo.

Conclusions

This study identified five robust metastatic signatures and proposed two metastatic probability clusters with stratified prognoses, multiomics landscapes, and treatment options. The current work not only provided new insight into the heterogeneity of renal cancer but also shed light on optimizing decision‐making in immunotherapy and chemotherapy.
Long term follow‐up after balloon expandable covered stents implantation for management of transcatheter aortic valve replacement related vascular access complications
Authors: Maurina Matteo , Condello Francesco , Mangieri Antonio , Sanz‐Sanchez Jorge , Stefanini Giulio Giuseppe , Bongiovanni Dario , Cozzi Ottavia , Leone Pier Pasquale , Baggio Sara , Gasparini Gabriele , Pagnotta Paolo , Civilini Efrem , Colombo Antonio , Reimers Bernhard , Regazzoli Damiano
Published: August 2022

Objectives

To report the experience of a high‐volume center with balloon‐expandable (BE) stents implantation to manage vascular complications after transcatheter aortic valve replacement (TAVR).

Background

Despite increased operator experience and better devices, vascular complications after TAVR are still a major issue and covered stent implantation is often required.

Methods

We retrospectively collected baseline and procedural data about 78 consecutive patients who underwent BE stent implantation to manage a vascular complication after transfemoral TAVR. Primary endpoints were technical success, incidence of new‐onset claudication and need for vascular interventions during long‐term follow‐up. Secondary endpoints included length of hospitalization, in‐hospital and 30‐day mortality, and major postoperative complications.

Results

BE stents implantation to manage vascular complications after TAVR was successfully performed in 96.2% of the cases, with bailout surgery required in two cases. One patient suffered in‐hospital death. Predischarge Doppler Ultrasound revealed no cases of in‐stent occlusion or fracture. At a median follow‐up of 429 days (interquartile range, 89−994 days), no cases of symptomatic leg ischemia were reported and only one patient experienced new‐onset claudication.

Conclusions

Our experience showed good periprocedural and long‐term results of BE covered stent implantation to manage vascular complication after TAVR. Their great radial outward force may guarantee effective hemostasis without necessarily being associated with stent deformation/fracture resulting in restenosis or further interventions. More research is needed to define the role of BE covered stents in this setting.
Kinetic Studies of Immobilized Wheat‐Based Alpha‐Naphthyl Acetate Esterase in the Detection of Organophosphate Pesticides
Authors: Nageib Adilah Mohamed , Jameel Ahmad Tariq , Ahmad Farah B.
Published: August 2022

Organophosphate pesticides could inhibit the activity of alpha‐naphthyl acetate esterase (ANAE), which could be the fundamental for biosensor applications. k‐carrageenan was used for immobilization of ANAE extracted from wheat‐based sources. The activity of ANAE was assessed for optimum activity at a range of temperature and pH. Enzyme kinetic studies were performed using Michaelis‐Menten kinetic parameters from Lineweaver‐Burk, Langmuir, and Eddie‐Hofstee. The optimization studies showed that the relative activity of the enzyme remained high, even above 50 °C. kd obtained was very low, which indicates the high sensitivity of ANAE towards pesticides. The kinetic reaction of ANAE showed the promising application of biosensors in the detection of pesticide.
Effect of Particle Size and Coke Formation on n‐Octane Dehydrogenation
Authors: Prucker Tobias , Lamberty Aliena , Thiessen Johannes , König Matthias , Jess Andreas
Published: August 2022

The effect of particle size as well as of coke formation on conversion of intermediate chain length paraffins (C6–C9) to the corresponding olefins was investigated on a promoted Pt catalyst with the model substance n‐octane. Increasing the particle size leads to pore diffusion limitations and thus to a reduction of the activity for paraffin conversion and of the octene selectivity caused by more pronounced formation of consecutive products (aromatics, octadienes). Both effects are adequately predicted by the developed kinetic model. The activity of dehydrogenation declines with the content of coke, but to a lesser extent than the rate of coke formation, which is beneficial regarding the catalyst lifetime. The initial activity is fully recovered by mild coke burn‐off (T < 470 °C).
Survival estimates of childhood malignancies treated at the Mexican telethon pediatric oncology hospital
Authors: Monárrez‐Espino Joel , Romero‐Rodriguez Lourdes , Escamilla‐Asiain Gabriela , Ellis‐Irigoyen Andrea , Cubría‐Juárez María del Pilar , Sematimba Douglas , Rodríguez‐Galindo Carlos , Vega‐Vega Lourdes
Published: August 2022

Background

Pediatric cancer incidence in Mexico is ~160/million/year with leukemias making 49.8% of the cases. While survival rates have been reported in various Mexican studies, no data is available from the Telethon Pediatric Oncology Hospital‐HITO, a nonprofit private institution specialized exclusively in comprehensive pediatric oncology care in the country that closely follows high‐income countries' advanced standards of cancer care.

Aim

To determine overall survival (OS) and relapse‐free survival (RFS) in patients treated at HITO between December 2013 and February 2018.

Methods and results

Secondary analysis of data extracted from medical records. It included 286 children aged 0–17 years diagnosed with various cancers grouped into three categories based on location: (1) Acute lymphoblastic leukemia (ALL), (2) tumors within the central nervous system (TWCNS), and (3) tumors outside the CNS (TOCNS). OS and RFS rates for patients who completed 1 (n = 230) and 3 (n = 132) years of follow‐up after admission were computed by sex, age, and cancer location, and separately for a subsample (1‐year = 191, 3‐years = 110) who fulfilled the HITO criteria (no prior treatment, underwent surgery/chemotherapy when indicated, and initiated therapy). TOCNS accounted for 45.1%, but ALL was the most frequent single diagnosis with 28%. Three‐year OS for patients with ALL, TWCNS, and TOCNS who fulfilled the HITO criteria were 91.9%, 86.7%, and 79.3%, respectively; for 3‐year RFS these were 89.2%, 60%, and 72.4%. Boys showed slightly higher OS and RFS, but no major differences or trends were seen by age group.

Conclusion

This study sets a relevant reference in terms of survival and relapse for children with cancer in Mexico treated at a private oncology center that uses a comprehensive and integrated therapeutic model.
A hybrid soft computing technique for intrusion detection in web and cloud environment
Authors: Maheswari K. G. , Siva C. , Nalinipriya G.
Published: August 2022

Cloud computing environment contains important, essential, or confidential information; therefore, a security solution is needed to prevent this environment from potential attacks. In short, cloud computing has become one of the most sought after technologies in the field of information technology, and among the most dangerous threats. In this article, we propose a hybrid soft computing technique for intrusion detection in web and cloud environment (ST‐IDS). In ST‐IDS, we illustrate whale integrated slap swarm optimization algorithm for pre‐processing which remove the unwanted/repeated data's in dataset. We introduce new clustering technique based on modified tug‐of‐war optimization algorithm which groups the data in different segments. Then, we develop hybrid machine learning technique that is, capsule learning based neural network which categorize the attack in cloud environment. Finally, the proposed ST‐IDS technique can evaluate through standard open source datasets are KDD cup'99 and NSL‐KDD. The performance comparison of the proposed ST‐IDS technique using existing innovative technologies in terms of accuracy, precession, recall, specificity, F measure, false positive rate, and false negative rate.
Vertebrae localization and spine segmentation on radiographic images for feature‐based curvature classification for scoliosis
Authors: Fatima Joddat , Mohsan Mashood , Jameel Amina , Akram Muhammad Usman , Muzaffar Syed Adeel
Published: August 2022

Spinal cord is the one of the most important organs in the central nervous system (CNS). It acts as the main processing hub which serves as the main passage line for information transfer from brain to the rest of the body. It supports the whole skeleton structure along with mobility, bending, turning, twisting and so forth. Several factors may result in the deformity of spine such as a major injury, fracture or a defect by birth. In this research, we have discussed two modules: one is for vertebrae localization and spine segmentation and the second one is for analysis of spine dis‐proportionality. A recent approach of YOLOv5 is used for the localization of vertebrae in combination with Mask RCNN for segmentation of spinal column. The combined results from both these modules are used for feature extraction which supports our classification‐based shape analysis module. The AASCE 2019 challenge dataset is used to evaluate the experimental results and the value of mAP achieved is 0.94 at 0.5 IOU threshold of YOLOv5 model. The proposed technique with novel feature set achieved an average classification accuracy of 94.69%.
Enabling green supply chain integration via green entrepreneurial orientation: Does environmental leadership matter?
Authors: Wang Gang , Feng Taiwen , Zhu Zhanguo , Jiang Yisa
Published: August 2022

Although both scholars and practitioners have recognized the crucial role of green supply chain integration (GSCI), our understanding of how green entrepreneurial orientation (GEO) may affect GSCI is scarce. Based on stakeholder theory and upper echelons theory, we examine whether GEO affects GSCI via environmental corporate strategy, and the moderating role of environmental leadership. We test the research hypotheses using multi‐sourced survey data from 264 Chinese firms. The results reveal that environmental corporate strategy partially mediates the impacts of GEO on green internal and external integration. Moreover, environmental leadership reinforces the impact of GEO on environmental corporate strategy while lessens the impact of environmental corporate strategy on green internal integration. However, the moderating effect of environmental leadership on the relationship between environmental corporate strategy and green external integration is not significant. This article provides theoretical contributions and managerial implications for the research on green entrepreneurship and GSCI.
Pituicytoma with pleomorphism: A case report with cytological findings
Authors: Shimizu Ayako , Nonami Yuji , Kanamuro Toshiko , Masui Kenta , Yamamoto Tomoko , Amano Kosaku , Kawamata Takakazu , Ichihara Atsuhiro , Nagashima Yoji
Published: August 2022

Pituicytoma is a rare neoplasm, arising in the posterior pituitary or in the hypophyseal stalk, and its cytological findings have not yet been well‐described. We have experienced a case of pituicytoma, which was difficult to diagnose intraoperatively, because of its cellular pleomorphism. A tumor measuring 18 mm in maximum diameter was found at the sella turcica in a Japanese woman in her forties. Both intraoperative crush cytology and histology of the resected tumor showed pleomorphic spindle or round cells, including multinucleated cells. Tumor cells were positive for TTF‐1, S‐100 protein, and vimentin, partially positive for glial fibrillary acidic protein and epithelial membrane antigen, and negative for synaptophysin, hormones of the anterior pituitary gland, CD34, Olig2, PAX8, and napsin A. Ki‐67 labeling index was 2.0%. Tumors included in the differential diagnosis in general are pituitary adenoma, craniopharyngioma, germinoma, and metastatic tumor on the radiological standpoint, and pilocytic astrocytoma and meningioma on the cytological standpoint. However, our case was difficult to differentiate especially from high‐grade glioma only by morphology, and immunohistochemistry including TTF‐1 was helpful.
Large flowers can be short‐lived: Insights from a high Andean cactus
Authors: Cuartas‐Domínguez Marcela , Robles Valeria , Arroyo Mary T. K.
Published: August 2022

Long‐lived and large flowers signify high floral maintenance costs. Species of arid/semiarid climates with large flowers are expected to have short flower life spans and pollination‐induced flower longevity in order to curb high floral water and other maintenance costs. We explored the context‐dependent large flower/short flower longevity hypothesis in Eriosyce curvispina (Cactaceae), a large‐flowered species of the semiarid central Chilean Andes. We determined breeding system, flower visitation rates, and open‐pollination fruit set and quantified floral water content. In a temperature‐controlled field manipulative experiment, we measured potential flower longevity and tested for the presence of pollination‐induced floral senescence. We measured the time span of the complete flower cycle defined as from when the flowers began to open to when they were totally closed, and the time span of fully open flowers defined as from when they were totally open until they began to close. The potential flower life span averaged 2.8 days (complete flower cycle) to 2.3 days (fully open flower). The complete flower cycle lasted 21.5 h, but flowers were fully open for only 10.1 h across days. Flower longevity in days was far shorter than reported for a large sample of species in the area. No evidence was found for pollination‐induced flower senescence as a complementary means for reducing floral maintenance costs. Eriosyce curvispina is self‐incompatible and abundantly pollinated by two megachilid bees. The level of pollen limitation (L = 0.36) was lower than the average reported for self‐incompatible angiosperms. Thus, the short flower life span in E. curvispina is not an impediment for high fruit set. Flowers contain >5 g of water of which >2 reside in >40 petaloid tepals. The amount of water is far higher than in another large‐flowered, non‐cactus species in the area, but only about 15% of that reported in the giant saguaro cactus which has larger flowers than E. curvispina.
Bioinspired NC Coated BM‐ZIF for Electrochemical Monitoring of Adrenaline from Blood and Pharmaceutical Samples
Authors: Shakeel Faria , Asad Muhammad , Zafar Farhan , Abdelwahab Adel A. , Akhtar(s) Naeem , Badaruddin Ahmad Hafiz , Shafiq Zahid , Shenashen Mohamed A.
Published: August 2022

Herein, we have developed highly sensitive and selective non‐enzymatic bioinspired polydopamine derived nitrogen rich carbon (NC) coated bimetallic zeolitic imidazolate framework (BM‐ZIF) electrochemical sensor via simple hydrothermal approach for monitoring adrenaline (AD) from COVID‐19 quarantined person blood and pharmaceutical sample. The designed NC‐BM‐ZIF electrode shows excellent sensitive and selective performance towards AD monitoring with detection limit (LOD) of 0.01 nM and 0.1931 μA/nM/cm2 sensitivity over a wide linear range of 50–1625 nM. To the best of our knowledge, this is the first study of using of NC‐BM‐ZIF electrode for the electrochemical sensing of AD from quarantined person blood and pharmaceutical sample.
Electrocatalytic Behavior of Manganese and Cobalt Porphyrins Attached to Graphene Quantum Dots: Applied in the Oxidation of Hydrazine
Authors: Jokazi Mbulelo , Mpeta Lekhetho S. , Nyokong Tebello
Published: August 2022

Manganese and cobalt metalated 5, 10, 15‐tris(aminophenyl)‐20‐(4‐carboxyphenyl) porphyrins (ClMnTA3CPP and CoTA3CPP) were synthesized and attached to graphene quantum dots (GQDs) via π‐π interaction and electrostatic interaction. The electrochemical oxidation of hydrazine was performed via cyclic voltammetry and chronoamperometry. The CoTA3CPP showed good electrocatalytic activity towards the oxidation of hydrazine in terms of catalytic rate constants and limits of detection (LoD). ClMnTA3CPP showed lower overpotential 0.60 V. The introduction of GQDs improved the electrocatalytic ability when combined with CoTA3CPP and ClMnTA3CPP with the lowest LoD (0.0025 mM CoTA3CPP–GQDs) followed by ClMnTA3CPP–GQDs with 0.0033 mM.
A Novel Electrochemical Sensor Based on Poly(1,5‐diaminonaphthalene) and Poly(1,2‐diaminoanthraquinone) Core‐shell Composite Electrodes for Effective Voltammetric Determination of Nitrite
Authors: Maher Reham , Khalifa Ziad , Hathoot Abla Ahmed , Azzem Magdi Abdel
Published: August 2022

In this article, poly(1,2‐diaminoanthraquinone) (pDAAQ) and poly(1,5‐diaminonaphthalene) (pDAN) were electrochemically deposited layer by layer on a glassy carbon electrode (GCE) to generate pDAAQ/pDAN@GCE and pDAN/pDAAQ@GCE composite electrodes, respectively. The morphology and characteristics of the modified electrodes were investigated via electrochemical impedance spectroscopy)EIS), Fourier transform infrared spectroscopy (FT‐IR), and scanning electron microscopy)SEM). The obtained results reveal the outstanding performance of the pDAN/pDAAQ@GCE electrode for electrochemical nitrite sensing where pDAAQ plays a vital role as the inner layer. Cyclic voltammetry (CV), linear sweep voltammetry (LSV), and differential pulse voltammetry (DPV) measurements revealed that the oxidation peak current of nitrite was proportional to its concentration. The best LSV results were obtained in a concentration range of 10–150 μM, with a limit of detection of 1.2 μM. Furthermore, the pDAN/pDAAQ@GCE composite electrode was used to determine nitrite ions in real water samples with good results.
CircRNA RNF10 inhibits tumorigenicity by targeting miR‐942‐5p/GOLIM4 axis in breast cancer
Authors: Kan Binghua , Yan Guiru , Shao Yuan , Zhang Ziliang , Xue Hui
Published: August 2022

We aimed to explore the action of a circRNA produced by ring finger protein 10 (circ_RNF10; hsa_circ_0028899) in the malignant behaviors of breast cancer (BC) and to explore its potential action‐of‐mechanism. The levels of circ_RNF10, miR‐942‐5p and Golgi integral membrane protein 4 (GOLIM4) were measured through quantitative real‐time polymerase chain reaction, western blot, or immunohistochemistry, and the competing endogenous RNA (ceRNA) relationship among them was verified by dual‐luciferase reporter assay. Cell counting kit‐8, 5‐ethynyl‐2′‐deoxyuridine, and colony formation assays, transwell assays, and flow cytometry were used to examine cell proliferation, migration and invasion, and apoptosis, respectively. Levels of proliferation and invasion‐related markers were determined by western blot. Xenograft assay was performed to assess tumor growth. Circ_RNF10 level was significantly reduced in BC tissues and cells. Elevation of circ_RNF10 blocked BC cell proliferation, migration and invasion while promoted the apoptosis in vitro, companied with decreased PCNA and Twist1 and increased E‐cadherin. Furthermore, upregulating circ_RNF10 delayed tumor growth of BC cells in nude mice. Mechanistically, circ_RNF10 acted as a ceRNA for miR‐942‐5p, and miR‐942‐5p could target GOLIM4. In addition, miR‐942‐5p overexpression reversed the influence of circ_RNF10 overexpression on BC progression. Furthermore, GOLIM4 silencing attenuated the inhibitory effect of miR‐942‐5p knockdown on BC progression. We found that circ_RNF10 suppressed BC malignant behavior by targeting miR‐942‐5p/GOLIM4 axis.
Effects of mulching with Solanum spp. straw on phosphorus, iron, and cadmium uptake by rice plants
Authors: Shi Jun , Lu Jing , Li Xiufen , Xiang Zufen , Liu Dingyou , Liao Shuang , Yu Huaqing , Zheng Tengda , Huang Tingyou
Published: August 2022

The cadmium (Cd) contaminated paddy soil has seriously affected the safe production of rice, and returning straw to fields changes the Cd accumulation in crops. To decrease the Cd accumulation in rice and clarify the relationships among phosphorus (P), iron, and Cd contents in rice, the effects of Solanum spp. (including non‐hyperaccumulators Solanum diphyllum and Solanum alatum, and Cd‐hyperaccumulators Solanum nigrum and Solanum photeinocarpum) straws on the P, iron, and Cd uptakes in rice in Cd‐contaminated soil were investigated. The application of four Solanum spp. straws increased the biomass of rice. Only the S. alatum straw increased the chlorophyll a, chlorophyll b, total chlorophyll, and carotenoid contents in rice. Regarding the P, iron, and Cd contents in rice, the four Solanum spp. straws either decreased the P content or had no significant effects, and tended to increase and decrease the iron and Cd contents, respectively. In addition, the Cd content was negatively correlated with the iron content and the soil available P concentration, and was positively correlated with the soil exchangeable Cd concentration. Therefore, Solanum spp. straws can decrease the Cd uptake and increase the iron uptake by rice. Furthermore, the Cd content in rice is related to the iron content in rice as well as the concentrations of soil available P and soil exchangeable Cd.
Effect of manifold injection of 1‐hexanol on a reactivity controlled compression ignition engine fuelled with neem oil methyl ester blend
Authors: Vajravel Vinodkumar , Alagu Karthikeyan
Published: August 2022

The novelty of this research aims to attain low‐temperature combustion with the help of reactivity controlled compression ignition (RCCI) in a single cylinder, four‐stroke diesel engine by premixing the low reactivity fuel (LRF) such as 1‐hexanol with air in the intake manifold along with high reactivity fuel (HRF) such as neem oil methyl ester in the volumetric ratio of 80:20 (B20) as a primary fuel. HRF has been utilized as a primary fuel through the main injector along with the manifold injection of LRF fuel through a secondary injector at various energy shares, such as 10%, 20%, 30%, and 40%, and the fuel combinations were designated as B20HI10, B20HI20, B20HI30, and B20HI40. The readings were noted from no load to full load and the experiment showed that the brake thermal efficiency (BTE) was increased in RCCI mode up to 30% 1‐hexanol share compared with B20 due to its better combustion, which was evident by higher heat release rate (HRR); beyond 30%, there was a drop in BTE due to the reduction in pilot fuel quantity. Oxides of nitrogen and smoke were significantly reduced for all combinations in RCCI mode, whereas hydrocarbon and carbon monoxide emissions were increased substantially. A substantial increase in peak pressure and HRR was noticed in RCCI mode compared with conventional mode due to its better homogeneity and prolonged ignition delay. From the findings, this research suggests that B20‐1‐hexanol combinations in RCCI mode can be an attractive replacement for diesel fuel.
Early administration of lenalidomide after allogeneic hematopoietic stem cell transplantation suppresses graft‐versus‐host disease by inhibiting T‐cell migration to the gastrointestinal tract
Authors: Tsubokura Yukie , Yoshimura Hideaki , Satake Atsushi , Nasa Yutaro , Tsuji Ryohei , Ito Tomoki , Nomura Shosaku
Published: August 2022

Introduction

Allogeneic hematopoietic stem cell transplantation (aHSCT) is a curative treatment for hematopoietic malignancies. Graft‐versus‐host disease (GVHD) is a major complication of aHSCT. After transplantation, the balance of immune conditions, such as proinflammatory cytokine level and T‐cell subset count, influences GVHD magnitude. Lenalidomide (LEN) is an immunomodulatory drug used for treating several hematological malignancies such as multiple myeloma, adult T‐cell lymphoma/leukemia, and follicular lymphoma. However, the impact of LEN on immune responses after aHSCT has not been elucidated.

Methods

We analyzed the lymphocyte composition in naïve mice treated with LEN. Subsequently, we treated host mice with LEN, soon after aHSCT, and analyzed GVHD severity as well as the composition and characteristics of lymphocytes associated with GVHD.

Results

Using a mouse model, we demonstrated the beneficial effects of LEN for treating acute GVHD. Although natural killer cells were slightly increased by LEN, it did not significantly change T‐cell proliferation and the balance of the T‐cell subset in naïve mice. LEN did not modulate the suppressive function of regulatory T cells (Tregs). Unexpectedly, LEN prevented severe GVHD in a mouse acute GVHD model. Donor‐derived lymphocytes were more numerous in host mice treated with LEN than in host mice treated with vehicle. Lymphocyte infiltration of the gastrointestinal tract in host mice treated with LEN was less severe compared to that in host mice treated with vehicle. The percentage of LPAM‐1 (α4β7‐integrin)‐expressing Foxp3−CD4+ T cells was significantly lower in host mice treated with LEN than in host mice treated with vehicle, whereas that of LPAM‐1‐expressing Tregs was comparable.

Conclusions

LEN may be useful as a prophylactic agent for acute GVHD‐induced mortality through the inhibition of lymphocyte migration to the gastrointestinal tract. Our data show the effect of LEN on immune responses early after aHSCT and suggest that cereblon, a molecular target of LEN, may be a therapeutic target for preventing acute GVHD‐induced mortality.
Brain and spinal cord metastases with seminoma: A case report
Authors: Yumioka Tetsuya , Morizane Shuichi , Makishima Karen , Adachi Tadashi , Moriyasu Emika , Iwamoto Hideto , Hikita Katsuya , Honda Masashi , Umekita Yoshihisa , Takenaka Atsushi
Published: August 2022

Introduction

Brain and spinal cord metastases from testicular cancer occur rarely, and metastases with seminoma are extremely rare.

Case presentation

A 42‐year‐old man who was diagnosed with seminoma and multiple metastases underwent first‐line and salvage chemotherapy. Brain metastases were noted; consequently, surgery, third‐line chemotherapy, and whole‐brain irradiation were performed. Subsequently, paralysis developed, and spinal cord metastases were detected. He received fourth‐line chemotherapy but died. Pathological autopsy revealed metastases only in the spinal cord. The cause of death was considered respiratory failure due to cervical spinal cord involvement from spinal metastases.

Conclusion

Brain and spinal cord metastases from seminoma are rare. Thus, similar future cases should be treated appropriately.
Distinctive nail pattern following androgen replacement therapy
Authors: Miyata Ippei , Nagai Atsushi
Published: August 2022

Introduction

A distinctive nail pattern in a patient undergoing androgen replacement therapy is presented hereby.

Case presentation

A 47‐year‐old male patient noticed a peculiar “washboard‐like” pattern on his fingernails. He had been undergoing androgen replacement therapy for late onset hypogonadism syndrome. The patient realized his nails were growing faster after his therapy was altered from a tri‐weekly basis to a bi‐weekly basis.

Conclusion

This phenomenon is likely to be attributed to the androgen replacement therapy, as the spacing between the ridges were widening in concordance with the strengthening of the therapy.
“My literacies expand over two languages”: Language and literacy autobiographies as justice‐oriented teacher education
Authors: Neville Mary , Johnson Susana Ibarra
Published: August 2022

In this study, the researchers explore how teacher candidates (TCs) across one content area literacies course and one bilingual education course engaged with their past linguistic experiences through two literacy autobiography assignments across the two separate classes. Borrowing from culturally sustaining, multiliteracies, and translanguaging pedagogies, the researchers examined students' associations with their past language and literacy experiences. Findings demonstrate that the assignment allowed participants to examine past linguistic experiences which informed their considerations of themselves and their future students as enactors of language and literacy. The researchers examine how a culturally sustaining, translingual, and multiliteracies approach may help TCs view their own and their future students' literacy repertories as texts.
In vitro assessment of varying peptide surface density on the suppression of angiogenesis by micelles displaying αvβ3 blocking peptides
Authors: Bhushan Neha Phani , Stack Trevor , Scott Evan A. , Shull Kenneth R. , Mathew Benjamin , Bijukumar Divya
Published: August 2022

Ligand targeted therapy (LTT) is a precision medicine strategy that can selectively target diseased cells while minimizing off‐target effects on healthy cells. Integrin‐targeted LTT has been developed recently for angiogenesis‐related diseases. However, the clinical success is based on the optimal design of the nanoparticles for inducing receptor clustering within the cell membrane. The current study focused on determining the surface density of Ser‐Asp‐Val containing anti‐integrin heptapeptide on poly (ethylene glycol)‐b‐poly(propylene sulfide) micelles (MC) required for anti‐angiogenic effects on HUVECs. Varying peptide density on PEG‐b‐PPS/Pep‐PA MCs (Pep‐PA‐Peptide‐palmitoleic acid) was used in comparison to a random peptide (SGV) and cRGD (cyclic‐Arginine‐Glycine‐Aspartic acid) construct at 5%‐density on MCs. Immunocytochemistry using CD51/CD31 antibody was performed to study the integrin blocking by MCs. In addition, the expression of VWF and PECAM‐1, cell migration and tube formation was evaluated in the presence of PEG‐b‐PPS/Pep‐PA MCs. The results show PEG‐b‐PPS/SDV‐PA MCs with 5%‐peptide density to achieve significantly higher αvβ3 blocking compared to random peptide as well as cRGD. In addition, αvβ3 blocking via MCs further reduced the expression of vWF and PECAM‐1 angiogenesis protein expression in HUVECs. Although a significant level of integrin blocking was observed for 1%‐peptide density on MCs, the cell migration and tube formation were not significantly affected. In conclusion, the results of this study demonstrate that the peptide surface density on PEG‐b‐PPS/Pep‐PA MCs has a significant impact in integrin blocking as well as inhibiting angiogenesis during LTT. The outcomes of this study provides insight into the design of ligand targeted nanocarriers for various disease conditions.