bluuebunny/crossref_metadata_2025 huggingface dataset:
Gender Bias in Chest Pain Evaluation in the Emergency Department: A 25-Year Update
Authors: Tolbert Abigail , Nemade, MD, MPH Dipali , Raines, MA, C-TAGME Jo Ann , Charles, MD Mitch , Wehner, MD Paulette , Shuler, MD, PhD Franklin
Published: March 2022

INTRODUCTION Due to having atypical presentations, women with potential cardiac disease may be approached and treated less aggressively than male patients. Differences in care along gender lines have been described at a university affiliated hospital in West Virginia (WV) in the past three decades. The purpose of this study is to determine if differences along gender lines in the care of patients with chest pain persists. METHODS From July-December of 2015, a retrospective chart review was performed at Cabell Huntington Hospital in WV. Data from 375 patients with a diagnosis of chest pain presenting to the emergency department (ED) was compared to data from 25 years prior. Symptoms, risk factors, medical history, medications, physical examination, laboratory, and electrocardiogram results, treatment in the emergency department, and ultimate diagnoses were studied. RESULTS Women had less reproducible musculoskeletal pain and more use of over-the-counter medicines, hormones, and pulmonary medications before presenting to the ED. Treatment with nitroglycerin and gastrointestinal medications occurred more commonly in women. Regarding evaluations of symptoms, women received more electrocardiograms, cardiac monitoring, and laboratory testing in comparison to 25 years prior. Cardiology consultations and emergency catheterization as well as the use of aspirin, heparin, antibiotics, anxiolytics, and thrombolytic agents were more commonly used in the treatment of women in comparison to 25 years prior. CONCLUSIONS In comparison to 25 years prior, there were documented improvements in the management of women presenting to the ED and experiencing new-onset, non-traumatic chest pain.
Integration of RFID tag in additive manufactured parts
Authors: Winkler Kerstin , Schubert Frank , Nendel Wolfgang , Kroll Lothar
Published: March 2022

This paper discusses the integration of on-metal tags in additively manufactured Ti-6Al-4V geometries. The manufactured components are to be equipped with information and read out due to aircraft maintenance work. Due to the complex installation and the mostly insufficient accessibility of the component in the installed state in the aircraft, a high read range and readability is mandatory. The integration involves ultra-high-frequency tags, which should promise a long range. The readability of the tags was therefore investigated in different open geometries. Here, some of the integrated tags were readable. In addition, tags were completely embedded in order to understand the effects in the component. The focus here was on the effects in the embedding chamber of the tag. Therefore, the fully embedded tags were cut open and examined. Some tags were readable, others were destroyed during the process. This was due, among other things, to the very hot environment of the process, as this depends highly on the actual permitted operating temperature of the tags. In addition, powder residues and adhesions were noted. These aspects are crucial for subsequent research involving the integration of tags.
Trump and Biden, Whose Policy is “Better”?
Authors: Liu Yinuo , Liu Xiaorong , Li Jiaxuan , Yu Rui
Published: March 2022

2020 is the year of US presidential election, with Republican candidate Donald Trump and Democratic counterpart Joe Biden running for president. In this paper, we focus on different president’s policy especially on economic field. In addition, “the different policies affect both America and China’s economy” is considered. This paper also gives some responds and suggestions for China to deal with different economic policies in America. Based on the instruction, we mainly solved three questions.To analyze different candidates’ economic policies and explore the impact in the U.S, we establish four series of factors by using Multiple Regression (MR) and then use Analytic Hierarchy Process (AHP) to build a whole model of general factors. Specially, we choose “COVID-19 fighting measures” to be the area we will explore, and we select Susceptible Exposed Infectives Recovered (SEIR) model to predict the impact caused by COVID-19. After that, all the advantages and disadvantages can be analyzed. If Donald Trump continues his political career, the development of American economy will be predicted by Gray model according to the GDP in previous years. Oppositely, if Joe Biden successfully runs for the president, some policies will be changed, and it is helpful to predict the GDP by using MR method. The conclusion shows that Biden’s policy is better than Trump’s for economy in the U.S.We build a new model to predict the possible impact of different candidates elected on China’s economy. The influence caused by different economic policies can be typically shown through several specific companies such as Huawei. Annual reports from different companies are collected and some data particularly related to international trade can be analyzed. Additionally, it is helpful to use Gray model and MR method to predict the companies’ economic situation on behalf of some significant parts of Chinese economy. From a historical point of view, the connectivity of the world economy, the collaborative division of labor among countries and the exchange of personnel are irreversible historical trends. No matter who the candidate is, our strategic approach to economic policy will not change, but some details may be changed. For Donald Trump’s policies, we will take national protection measures in some high-tech areas. But for Biden, the policy in China must be changed.
Impact of the Algebra I End of Course Examination on African American Students Obtaining a Standard High School Diploma
Authors: Green-Jones Jamillah D. , Collins Paul K.S. , Hope Warren C.
Published: March 2022

The state of Florida requires all students complete Algebra I and pass the End of Course Examination (EOCE) to graduate with a standard high school diploma. Algebra I EOCE results indicate that many African American students do not pass the examination. This research sought to determine if there is a relationship between African American students’ failure to pass the Algebra I EOCE and graduate with a standard diploma. Four hypotheses, null and alternative were tested. Two ninth-grade cohorts, 2013-2014 and 2014-2015 comprised the sample. Data were analyzed using t test and one-way analyses of variance (ANOVA). Results indicate a significant relationship between African American students’ failure to pass the Algebra I EOCE and graduation with a standard high school diploma.
DESIGN AND EVALUATION OF FAST DISSOLVING GRANULES OF SALBUTAMOL SULFATE
Authors: AL-MOUSAWY JINAN M. , ASHOOR JAMAL A. , MOHAMMED ALI MUQDAM M.
Published: March 2022

Objective: Appropriateness of administration and patient complaints are important factors in developing dosage forms, especially for children and elderly people. The goal of this research was to develop salbutamol sulfate granules that dissolve quickly to improve patient compliance.
Methods: Five formulas (F1-F5) were prepared by wet granulation methods. Different type of excipients was used in the formulation like banana powder as super disinterring, mannitol, hydroxyl propyl methylcellulose; etc. The formulas were evaluated for flow properties, drug compatibility study by FTIR, drug content, and drug release profile.
Results: The result revealed that the flowability of the five formulas has accepted flow properties; The FTIR studies of the formula F2 showed no drug-excipients interaction. All of the prepared formulas show an acceptable range of drug content, a rapid release of drug of about 95.2% within 10 min. These results indicate good and rapid release properties of salbutamol sulfate from fast dissolving granules.
Conclusion: Salbutamol sulfate was successfully formulated as fast-dissolving granules by using banana powder.
FORMULATION AND EVALUATION OF TWO CELASTROL NANOEMULSIONS PREPARED FROM TWO OILS: ISOPROPYL MYRISTATE AND VIRGIN COCONUT OIL
Authors: ABDULLAH NUR ALAM , JUFRI MAHDI , MUN’IM ABDUL , SAPUTRI FADLINA CHANY
Published: March 2022

Objective: Celastrol, which is classified as BCS 4, needs to be developed into a nanoemulsion formula for a stable and good formulation. The aim of the study was to determine the in vitro penetration ability and adsorption efficiency (EE) between two different base oils, namely Isopropyl myristate (IPM) and virgin coconut. oil (VCO).
Methods: Two celastrol nanoemulsion formulas were prepared by high energy method using High share homogenizer (HSH) at 15,000 rpm for 15 min, using different oil-based components, F1 IPM and F2 VCO. Particle size, polydispersity index (PDI), D90, zeta potential, and morphology of nanoemulsions was evaluated. In vitro studies by Franz diffusion cell test method determined the difference.
Results: The results showed that celastrol can be formulated well with a ternary ratio of 5:45:50 for IPM and 20:30:50 for VCO. The absorption efficiency test for celestrol levels was 96.49%±2.72 for IPM and 76.53%±1.19 for VCO. The mean particle size, PDI, and zeta potential were 70.81±0.20 nm, 0.1±0.03, and 50.2±0.60 mV, for VCO and 186.23±3, respectively. 12 nm, 0.2±0.07, and 45.5±1.10 mV for HDI. Spherical morphology<200 nm. Franz diffusion in vitro at 20 and 24 h, celastrol is well penetrated at levels of 2.4 g/ml gram and 2.5 g/ml for HDI and at 2.0 g/ml gram and 2.4 g/ml, respectively. ml/gram for VCO.
Conclusion: Celastrol was successfully developed into nanoemulsions using IPM or VCO, particle size<200 nm, and stable spherical shape.
ENHANCEMENT OF BIOAVAILABILITY OF GLIPIZIDE USING SOLID DISPERSIONS WITH GUM AEGLE MARMELOS
Authors: MALLICK S. , MAHAPATRA A. K. , MURTHY P. N. , PATRA RUCHITA KUMARI
Published: March 2022

Objective: The aim of the proposed study was formulation and in vitro/ vivo evolution   of solid dispersions of glipizide with gum Aegle marmelos.
Methods: The phase solubility of glipizide in 0.1N HCl was investigated in the presence of different concentrations of gum Aegle marmelos. The solid dispersions (SDs) of glipizide with gum Aegle marmelos were formulated using solvent evaporation method at ratios of 1:1, 1:2, and 1:5 (glipizide: gum Aegle marmelos). Dissolution studies were conducted. The physicochemical characterization of the formulations was performed by using Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Subsequently, bioavailability of pure glipizide, solid dispersion and marketed product was performed in rat.
Results: Glipizide solubility increased as the concentration of gum Aegle marmelos in 0.1N HCl was raised. The solubility study indicates spontaneous drug solubilization, which is supported by negative values of Gibb's free energy (ΔGotr). Glipizide rate of dissolution was increased in SDs containing gum, and the rate increased as the concentration of gum in the SDs increases. After preparing SDs and physical mixtures with gum, the mean dissolution time (MDT) of glipizide decreases considerably. FTIR spectroscopy study revealed that stability and the absence of a well-defined glipizide-gum interaction. The amorphous condition of glipizide in SDs of glipizide with gum was revealed by DSC and XRD studies.
Conclusion: The DSC and XRD studies indicate conversion of drug from crystalline to microcrystalline or amorphous form after formulation of solid dispersion with Aegle gum. The solid dispersion of glipizide with Aegle gum (893.04±25.5) showed better therapeutic activity compared to pure glipizide (535.65±11.5) and marketed formulation (767.5±13.6).
DESIGN AND EVALUATION OF LIQUISOLID COMPACTS OF NEBIVOLOL HYDROCHLORIDE
Authors: SURA RAMYA SRI , SUBRAHMANYAM CVS , RACHAMALLA SHYAM SUNDER
Published: March 2022

Objective: The aim of this study was to investigate the potential of a liquisolid system to improve the dissolution rate and the bioavailability of nebivolol hydrochloride.
Methods: Solubility of nebivolol was determined in different nonvolatile solvents to finalize the best nonvolatile vehicle having maximum solubility. The liquisolid compacts were prepared using Fujicalin as a carrier material, Aerosil 200 as a coating material, Polyethylene glycol 400 as a liquid vehicle, and Croscarmellose sodium as a super disintegrating agent. 23 full factorial design was used to optimize the formulation in which the drug concentration, PVP K 30, Excipient ratio (R), and nebivolol containing nonvolatile solvent liquid level were selected as independent variables by using design expert software. The eight liquisolid compact formulations were prepared. Nebivolol liquisolid compacts were evaluated for drug content, tablet hardness, Friability, disintegration, and dissolution. An in vivo study was carried out in male Wistar rats.
Results: The solubility of nebivolol hydrochloride in polyethylene glycol 400 was found to be greater than the other nonvolatile solvents. The liquisolid system of nebivolol was formulated successfully using Fujicalin, Aerosil 200, and polyethylene glycol 400. In vitro evaluation parameters for the liquisolid compact were within the prescribed limits. It was found that optimized liquisolid tablet formulation showed higher dissolution than the marketed tablet, with 88.33±0.94 % drug release within 120 min and the drug release was more than 75 % in 30 min for nebivolol LS-3N, which is optimized. LS-3N liquisolid compacts follow the Peppas model and exhibited first-order release.
Conclusion: The liquisolid compacts can be a promising alternative for the formulation of water-insoluble drug nebivolol hydrochloride with improved dissolution and bioavailability.
SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEM OF URSOLIC ACID: FORMULATION DEVELOPMENT, CHARACTERIZATION, PHARMACOKINETIC AND PHARMACODYNAMIC STUDIES FOR DIABETIC COMPLICATIONS
Authors: MOULI GOLLA CHANDRA , VEERESHAM CIDDI
Published: March 2022

Objective: The objective of this study was to develop, characterize, and conduct pharmacokinetic and pharmacodynamic studies on ursolic acid solid self microemulsifying drug delivery system (UA-S-SMEDDS) for the treatment of diabetic complications.
Methods: Liquid self microemulsifying drug delivery system (L-SMEDDS) were made with Capryol 90 as an oil, Cremophor EL as a surfactant, and polyethylene glycol (PEG) 400 as a co-surfactant. The surfactant and co-surfactant (Smix) ratios were calculated using a pseudo ternary phase diagram. At different pH levels and with water, the globule size, polydispersity index (PDI), zeta potential (ZP), and dilution were all assessed. S-SMEDDS has developed adsorption to a solid carrier by utilizing L-SMEEDS formulation. The powder properties, liquid retention potential, globule size, PDI, ZP, assay, and pharmacokinetic studies were all evaluated. The pharmacodynamic investigations of the S-SMEDDS formulation in streptozotocin (STZ) induced Wistar rats were evaluated using malondialdehyde (MDA) and glutathione (GSH) determination in tissues and section studies.
Results: S-SMEDDS formulation was successfully developed with a droplet size of 163.4±1.475 nm, PDI of 0.251±0.042, a ZP of-21.3±1.02, an assay of 96.21±0.75%. The release studies showed 26.28% (0.1N HCl) and 83.57% (6.8 phosphate buffer) were released in 15 min. When comparing the pharmacokinetics of a UA-loaded S-SMEDDS to the coarse suspension, the S-SMEDDS (F2A) showed a 4.12 fold improvement in UA oral bioavailability. The pharmacodynamic results showed that S-SMEDDS was a higher recovery rate.
Conclusion: The developed solid SMEDDS (F2A) formulation proved effective in treating diabetic complications in STZ induced Wistar rats by inhibiting the aldose reductase enzyme.
DESIGN AND EVALUATION OF BOSENTAN CONTROLLED-RELEASE MICROCAPSULES
Authors: KOREDDI HARSHA , SURYADEVARA VIDYADHARA , TALAMANCHI BALAKRISHNA , ANNE RAMU
Published: March 2022

Objective: The objective of the present work is to formulate and evaluate Bosentan controlled-release microcapsules using gum karaya and polyethylene oxide as polymers, sodium alginate and calcium chloride as encapsulating material and cross-linking agent and croscarmellose sodium as superdisintegrant.
Methods: Bosentan microcapsules were prepared by the ionic gelation method. The prepared microcapsules were characterized by flow properties such as angle of repose, compressibility index, particle size and encapsulation efficiency and drug release profiles.
Results: The prepared microcapsules were evaluated for angle of repose, compressibility index, % drug content, encapsulation efficiency and particle size. All the flow properties were within the specified IP limits. The drug content of microcapsules prepared by ionic gelation method by varying the polymeric concentration was found in the range of 121.62±0.41 to 124.99±0.51 mg. The encapsulation efficiency of Bosentan controlled-release microcapsules was found to be in the range of 59 % to 67%. Among all the formulations prepared, formulation B14 containing equal proportions (25 mg) of gum karaya and polyethylene oxide showed about 95% of drug release over a period of 12 h and were found to be suitable for extending drug release up to 16 h.
Conclusion: Bosentan controlled-release microcapsules were prepared by ionic gelation method, which is a novel formulation that is helpful in the treatment of pulmonary artery hypertension (PAH).
IDENTIFICATION OF FGFR INHIBITOR AS ST2 RECEPTOR/INTERLEUKIN-1 RECEPTOR-LIKE 1 INHIBITOR IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE DUE TO EXPOSURE TO E-CIGARETTES BY NETWORK PHARMACOLOGY AND MOLECULAR DOCKING PREDICTION
Authors: NURHIDAYAH MUTHIA , FADILAH FADILAH , ARSIANTI ADE , BAHTIAR ANTON
Published: March 2022

Objective: This study was designed to search for candidate drugs that act on IL-33 and ST2, which was carried out using a bioinformatics approach.
Methods: We first analyzed Network Electronic Cigarette Smokes Predictions of therapeutic targets by Cytoscape. We collected from the Swiss TargetPrediction database [http://www. swisstargetprediction. ch/] by inputting each compound structure of the electronic cigarette smoke in SDF format. The target protein data is then supplemented with UniProt ID data to uniform protein identity. We then identified COPD Related Targets in Humans by Cytoscape. Subsequently, we identified key receptors in the pathogenesis of COPD. All target proteins that have a significant role in the pathogenesis of COPD exposed to cigarette smoke will be known from the combination of this network.
Results: Based on the validation results of the protein receptor for ST2, a protein is used as a receptor with PDB ID: 1IRA. After analyzed by PyMol software, a protein with PDB ID 1IRA it has no missing residue in its sequenceDrug candidates analyzed by the structural similarity with the native ligand using PubChem and DRUGBANK analysis are follow: N-acetylmannosamine, Aceneuramic acid, Ceramide AP, Ceramide NP, Hg9a-9, Nonanoyl-N-hydroxyethylglucamide, N-Acetyl-2-deoxy-2-amino-galactose, N-Acetyllactosamine, MLi/2,6-dimethyl-4-[6-[5-[1-methylcyclopropyl] oxy-1H-indazol-3-yl] pyrimidin-4-yl] morpholine, Terazosin, BMS-911543, NAG Inhibitor, FGFR Inhibitor/sodium; 2-amino-5-[1-methoxy-2-methylindolizine-3-carbonyl] benzoate. After docking, the smallest or more negative binding affinity values are obtained. The stronger the FGFR Inhibitor ligand showed the interaction with the Receptor with a binding affinity value of-9.0 kcal/mol with mode/position 0, and RMSD 0.0. The second smallest binding affinity value is the NAG ligand with a-8.5 kcal/mol with mode/position 0 and RMSD 0.0.
Conclusion: The findings revealed that FGFR Inhibitor was a suitable repurposing medication for anti-COPD development via the IL-33/ST-2 signaling pathway.
Атермализованные телевизионные объективы
Authors: Шишкин И.П. , Шкадаревич А.П.
Published: March 2022

Представлена конструкция атермализованных телевизионных объективов для систем наблюдения: 3‑линзовый телеобъектив с относительным отверстием F / 5.6, 7‑линзовый апохромат с относительным отверстием F / 4 и 9‑линзовый объектив c относительным отверстием F / 2.8. При расчете объективов учтена совокупность факторов, которые влияют на величину расчетного разрешения объектива: размер сенсора, фокусное расстояние, относительное отверстие. Но в реальном производстве при сборке конструкции объектива не всегда можно достичь расчетного качества изображения. Рассмотрена чувствительность оптических схем к допускам конструкции.
О возможности обнаружения космических объектов в спектральном диапазоне 8–12 мкм
Authors: Знаменский И.В. , Тунгушпаев А.Т.
Published: March 2022

Представлен результат расчета пороговой освещенности оптико-­электронной системы (ОЭС) в дальнем ИК-диапазоне 8–12 мкм. Разработана методика и выполнен расчет освещенности входного зрачка ОЭС от сигнала космического объекта (КО) цилиндрической формы подсвеченного Солнцем и за счет собственного излучения КО. Построена зависимость дальности до КО от отношения сигнал-шум.
D Dimer and Prothrombin Time as a Prognotic Marker of Covid 19 Morbidity and Mortality: A Retrospective Analysis
Authors: Thomas Prince , J Rahees , K P Bijitha
Published: March 2022

Abstract: To analyse the value of coagulation indicators D Dimer and PT. D Dimer and PT as a prognostic marker of covid 19 morbidity and mortality. A total of 230 patients with confirmed covid 19 at the time of admission between march 5 to June 19 2021 are included in the study. The changes in D Dimer and PT are tested with their clinical classification and disease prognosis are studied. Result showed that coagulation disorders occurs at early stages of infection with 78.3 % patients having D Dimer increased, PT analysis shows 10 abnormal value in 46 deceased patients. The level of D Dimer and PT are compared with clinical classification. Among 46 patients who died of covid 19 36 had increased DD levels at their 1st laboratory investigation, 44 had DD increased at 2nd and 3rd lab test. ROC analysis in predicting morbidity and mortality rate showed that DD levels were o.742.0.818 and 0.851 respectively. PT levels were 0.643,0.824 and 0.937 respectively. The probability value of DD (P<0.01) indicate the severeneous of DD levels and covid 19. The study concluded that coagulation dysfunction is severe in critically ill patients and patients who are having lifestyle disorders and aging.DD and PT values can be used as a significant tool for making predictions of morbidity and mortality rate in severe covid 19 infection Keywords: Include at least 5 keywords or phrases D Dimer, Prothrombin time, Covid 19, cardiac arrest, Fibrinogen
Mood Based Music Playlist Generator Using Convolutional Neural Network
Authors: Upadhyay Prof. Jaychand , Shetty Sharan , Murari Vaibhav , Trinidade Jarvis
Published: March 2022

Abstract: Music is used in one’s everyday life to modulate, enhance, and plummet undesirable emotional states like stress, fatigue, or anxiety. Even though in today's modern world, with the ever-increasing advancement in the area of multimedia content and usage, various intuitive music players with various options have been developed, the user still has to manually browse through the list of songs and select songs that complement and suit his or her current mood. This paper aims to solve this issue of the manual finding of songs to suit one’s mood along with creating a high accuracy CNN model for Facial emotion recognition. Through the webcam, the emotional state can be deduced from facial expressions. To create a neural network model, the CNN classifier was used. This model is trained and tested using OpenCV to detect mood from facial expressions. A playlist will be generated through the system according to the mood predicted by the model. The model used for predicting the mood obtained an accuracy of 97.42% with 0.09 loss on the training data from the FER2013 Dataset. Keywords: Convolutional neural networks, Facial emotion recognition, FER2013, Music, OpenCV.
Response of LQ45 Stock Market on Indonesia Legislative and Presidential Election Result in 2019
Authors: Frihartina Siti Rahmani , Mursidi Mursidi , Nurjannah Dewi
Published: March 2022

The purpose of this study was to determine the response of LQ45 stock market participants to the legislative and presidential elections and the results of the 2019 presidential election. The data used to determine the response of market participants is to use abnormal return data and trading volume activity from 45 companies listed on LQ45. The test is then calculated using the marked adjusted model method and testing the hypothesis using parametric statistics and analyzed using SPSS. Based on the results of research conducted, it can be concluded that for the legislative and presidential election events, in 2019 there were significant abnormal return differences and for trading volume activity there were no significant differences around the day the event occurred. The second political event, namely the results of the presidential election, the calculation of abnormal returns and trading volume activity around the day of the event was found to be a significant difference in which this event there was a response from the stock market players which means that both hypotheses in this study were accepted in this second political event.
The Effect of Social Media Instagram Promotion on The Sale of Mariposa Novel
Authors: Fajriyah Hidayatul , Marsudi Marsudi
Published: March 2022

This research aims to analyze the effect of promotion on social media Instagram towards the selling of Mariposa novels. The sampling technique used in this research was the purposive sampling technique with the criteria: Mariposa novel’s sales report after being published in bookstores in 2019. In order to know the effect of social media on the selling of Mariposa novel, a statistic test namely paired sample t-test was carried out by the researcher. By dividing the sales report into two categories: sales report before the social media promotion treatment (sales report on January to June 2019) and after social media promotion treatment (sales report on July to December 2019). The result showed that the significant value was 0,028 (which is smaller than 0,05). Thus, the promotion on social media Instagram had a significant effect on the selling of Mariposa novel.
Efforts in Finding and Maintaining Business in the New Normal Era
Authors: Reyhan Ibrahim Reyhan Nugraha Putra , Faizah Ifah Nur , Putri Sheila Febriani
Published: March 2022

This research was conducted to answer what business actors can do to be able to maintain their business amid the COVID-19 pandemic that is sweeping the world. This study also aims to describe what are the survival strategies that must be carried out by business actors. Therefore, they can survive and become more responsive and adaptable to business changes, especially during the current COVID-19 pandemic. Usually, even though there are online sales, many consumers still buy products directly at the store or shopping center. The research method used in this research is descriptive qualitative which is the right type of research to capture human perception with direct contact through an inductive process and symbolic interaction. Using literature review, the decomposition of the data was obtained. This research provides an opinion in finding opportunities and maintaining business in the new normal era for MSME in the form of recognizing consumer behavior, improving quality and services, using technology in MSME in the form of digital marketing, building synergies between digital MSME and citizens, and use the Customer relationship marketing (CRM).
The Effect of Liquidity and Solvability on the Profitability of Banking Companies Listed on the Indonesia Stock Exchange in 2017-2019
Authors: Jannah Tiara Rizky Miftachul , Mursidi Mursidi , Widayat Widayat
Published: March 2022

The purpose of this study was to determine the effect of liquidity and solvability on the profitability of banking companies listed on the Indonesian stock exchange for the 2017-2019 period. The population used in this study is data on loan to deposit ratio, debt to, capital adequacy ratio, and ROA. The sample taken is data from the 2017-2019 period as many as 28 banking companies. The data analysis technique in this study uses multiple linear regression, while the analytical tool used is SPPS version 25. The results of this study state that the projected liquidity variable with the loan to deposit ratio has no significant effect on company profitability. The solvability variable projected by the capital adequacy ratio has no significant effect on the company's profitability. The liquidity variable projected by the loan to deposit ratio, and the solvability variable projected by the capital adequacy ratio simultaneously do not affect the company's profitability, and the most influential variable on profitability is solvability projected by the capital adequacy ratio (CAR).
Una momia suvenir. Reflexiones sobre el coleccionismo privado en Chile a partir del caso de la colección egipcia de Pedro del Río Zañartu (S. XIX inicios S. XX)
Authors: Valenzuela Matus Carolina Andrea
Published: March 2022

El coleccionismo de piezas del Antiguo Egipto atrajo la atención tanto de élites eu-ropeas como hispanoamericanas durante los siglos XIX e inicios del XX. En Chile, el caso de la colección existente en el Museo Pedro del Río Zañartu en Hualpén (región del Bío-Bío) es bastante particular, al ser la única de su clase en exhibición permanente en el país. El coleccionista que da nombre al museo acopió distintas piezas, las que hasta el día de hoy presentan dudas acerca de su procedencia, forma de adquisición y datación. El presente es-tudio tiene como objetivo aproximarse al fenómeno del coleccionismo en la época señalada, analizando su contexto y reflexionando sobre la formación de la colección del Museo Pedro del Río Zañartu, evidenciando su valor patrimonial a partir de la profundización sobre una de las piezas más icónicas del museo: una momia egipcia
PODCAST SEBAGAI MEDIA DAKWAH ERA PANDEMI
Authors: Ariyanto Panji Putra
Published: March 2022

This research wants to know the potential use of podcasts as providers of da'wah content. Da'wah is one of the mandatory processes of humans in living their lives. Da'wah activities will experience changes and adjustments along with the development of human life. Da'wah is everything that can be done at any time, place and condition including in the covid-19 pandemic. Podcasts become one of the alternative mediums of community or individual in spreading the treatises on Islamic values.Â This research usedÂ descriptive qualitative research method with literature study type. The conclusion of this research is that Podcasts are quite capable and suitable as a medium for disseminating da'wah with a note that they must develop relevant strategies that can improve their existences.
RESPONS PENYELENGGARA PERJALANAN IBADAH UMRAH TERHADAP LARANGAN MEMFASILITASI DANA TALANGAN DALAM PMA NO 8 TAHUN 2018
Authors: Nurdiawati Riskyi , Triatmo Agus Wahyu
Published: March 2022

This researchÂ aims to analyze the policy of paying the hajj bailout funds carried out by means of a monthly scheme after the pilgrims return from the Holy Land. This is contrary to PMA No.8 of 2018Â which statesÂ that PPIU is prohibited from facilitating congregations using bailout funds. However, this is still being implemented by PPIU in Surakarta even though they are guided by PMA. The research method used in this research is descriptive qualitative. The data sources were explored by interview and policy documentation. It was concluded that the PPIU response in Surakarta to PMA No. 8 of 2018 did not expect that there was a ban on facilitating congregations to useÂ theÂ bailout funds because PPIU provided all the same facilities and services as regular congregations. PPIU in increasing the number of congregants had made several programs, one of which was the bailout funds. The societyâ€™s interest in using the bailout funds reaches 50%. The bailout fundsÂ couldÂ help the middle and lower class economic community to carry out the Umrah pilgrimage. The bailout program was organized by a third party in the financial provider. The bailout fund was not part of the PPIU program so that it was considered not a problem because it was carried out openly and the Ministry of Religious AffairsÂ didÂ not carry out supervision from the start starting from the financing or PPIU. The lack of supervision by the Ministry of Religious AffairsÂ becameÂ a factor in the occurrence of violations.
INSTAGRAM, PANDEMI DAN PERAN INFLUENCER (Analisis Wacana Kritis pada Postingan Akun Instagram @najwashihab dan @jrxsid)
Authors: Zuhri Achmad
Published: March 2022

The spread of information relatesÂ to Covid-19 on social media increasingly widespread causesÂ the government to use persuasive communication patterns.Â However, the communication strategiesÂ carried out by the government through influencers doÂ not fully receive support. The Instagram accounts of @najwashihab and @jrxsid are interesting to study because they have such a wide influence on the way the public views this pandemic. The construction of discourse developed by their Instagram content was analyzed. This study usedÂ critical discourse analysis method of text and documentation as well as content display analysis. It is found that these accounts haveÂ a variety of views in understanding the covid-19 phenomenon. Through textual analysis, social cognition,Â and social concepts initiated by Teun Van Dijk, these accounts incorporate the cognitive abilities in their posts. The @najwashihab account is much more acceptable than @jrxsid because its argument is in line with the narrative developed by the government. The language style used by @jrxsid shows a critical attitude towards policies that are pro to WHO. However, @jrxsidreceives more provocative comments from the followers than the @najwashihab account. In the same way, these accounts have similarities in their concern for the people affected by Covid-19. Both accounts have creativity in displaying content with an attractive visual style and have social responsibility.
ANALISA WORD OF MOUTH DAN TRUTH TERHADAP MINAT HAJI KHUSUS (Studi di Dewangga Lil Hajj Wal Umrah Surakarta)
Authors: Salma Nury , Yuliar Ade
Published: March 2022

This study aims to analyze the effect of word of mouth and trust towardsÂ the interest of pilgrims to register exclusiveÂ Hajj in Dewangga Lil Hajj Wal Umrah Surakarta. The dependent variable in this study isÂ the interest of pilgrimsÂ registering exclusiveÂ hajj. Meanwhile, the independent variables areÂ word of mouth and service trust. The population in this study includedÂ all pilgrims who have registered a specialÂ Hajj package. The sampleÂ was selected using the accidental sampling method and obtained 30 respondents. This studyÂ was a quantitative study using multiple linear regressions as an analysis technique. The results show that word of mouth has no significant effect onÂ the interest of pilgrims registering exclusiveÂ hajj. Furthermore, the truthÂ has a significant effect onÂ the readabilityÂ of pilgrims registering exclusiveÂ hajj.
KETERPAPARAN HOAKS VAKSIN COVID-19 DALAM PROSES KOGNITIF WARGANET INDONESIA
Authors: Handini Handini , Mubarok Achmad Fadloli , Kholiq Muhammad Abdul
Published: March 2022

Artikel ini membahas fenomena keterpaparan hoaks vaksin COVID-19 pada warganet di Indonesia. Sejumlah penelitian terdahulu mengungkapkan bahwa fenomena tersebut muncul sebagai akibat langsung dari derasnya arus informasi hoaks di media digital. Meningkatnya jumlah pengguna internet serta lemahnya pengaturan negara dalam mengawasi lalu lintas informasi digital dianggap telah menciptakan lingkungan yang menyuburkan konten hoaks. Kondisi ini menempatkan warganet pada situasi yang rentan terpapar hoaks vaksin COVID-19. Namun, berbeda dengan kesimpulan tersebut, penelitian ini menemukan bahwa tingkat literasi digital warganet memiliki peran yang paling signifikan dalam fenomena keterpaparan hoaks vaksin COVID-19. Dalam hal ini, penerimaan informasi oleh pengguna media digital (user) perlu dilihat sebagai proses pengambilan keputusan yang dihasilkan oleh lingkungan-internal kognitif dirinya. Secara konseptual, seorang user yang mempercayai sebuah hoaks telah melewati proses membuat pertimbangan dan sampai pada tahap memutuskan satu pilihan sikap yang paling memuaskan bagi dirinya. Dengan menggunakan teori rasionalitas terbatas (bounded rationality), penelitian ini menjelaskan bagaimana keterpaparan informasi hoaks vaksin Covid-19 pada warganet berkaitan dengan keputusan mereka untuk mengakses informasi tersebut di media digital. Keterbatasan untuk mengoptimalkan sikap rasional ketika menanggapi informasi hoaks dan dampak negatifnya menyebabkan warganet cenderung menerima suatu info tanpa melakukan klarifikasi yang mendalam. Perilaku ini mendorongnya untuk mencari dan menerima informasi pendukung lain yang cenderung menguatkan narasi yang sudah dipercayai sebelumnya.
Bovine milk microbiota: Evaluation of different DNA extraction protocols for challenging samples
Authors: Schwenker Julia , Friedrichsen Meike , Waschina Silvio , Bang Corinna , Franke A. , Mayer Ricarda , Hölzel Christina
Published: March 2022

The use of an adequate protocol that accurately extracts microbial DNA
from bovine milk samples is of importance for downstream analysis such
as 16S rRNA gene sequencing. Although sequencing platforms such as
Illumina are very common, there are reservations concerning
reproducibility in challenging samples that combine low bacterial loads
with high amounts of host DNA. The objective of this study was to
evaluate six different DNA extraction protocols applied to four
different prototype milk samples (low/high level of colony-forming units
(cfu) and somatic cells). DNA extracts were sequenced on Illumina MiSeq
with primers for the hypervariable regions V1V2 and V3V4. The different
protocols were evaluated by analyzing the yield and purity of DNA
extracts and the number of clean reads after sequencing. Three protocols
with the highest median number of clean reads were selected. To assess
reproducibility, these extraction replicates were re-sequenced in
triplicates (n=120). The most reproducible results for alpha- and
beta-diversity were obtained with the modified DNeasy Blood & Tissue
kit after a chemical pre-treatment plus resuspension of the cream
fraction. The unmodified QIAamp DNA Mini kit performed particularly weak
in the sample representing unspecific mastitis. These results suggest
that pre-treatment in combination with the modified DNeasy Blood &
Tissue kit is useful in extracting microbial DNA from challenging milk
samples. To increase reproducibility, we recommend that duplicates, if
not triplicates, should be sequenced. We showed that high counts of
somatic cells challenged DNA extraction, which shapes the need to apply
modified extraction protocols.
The need for IUCN species distribution update - the case from a large threaten ungulate in Southwest China
Authors: Guan Tianpei , Owens Jacob , Yang Jian , Yang Kong , Gu Xiaodong , Song Yanling
Published: March 2022

Species distributions are one of the fundamental factors needed for
understanding and conserving wildlife. While the IUCN Red List of
Threatened Species is the primary applied reference for biodiversity
conservation, limitations in data availability and analyses of the
distributions of some species may limit accurate threat classification
assessments and conservation recommendations. Improving the accuracy of
species distributions in light of growing data and analytical methods is
a key step to increasing the efficacy of the Red List. In this study, we
reassessed the distribution of takin (Budorcas taxicolor tibetana), a
large ungulate in Sichuan Province, southwest China , classified by the
IUCN as vulnerable. Using species distribution models and reported
habitat requirements, we updated the takin distribution map. Our updated
distribution range in the study area (79,449km2) was 61.31% of current
distribution range (CDR) on the IUCN red list. This reduction was in
large part due to the inclusion in the CDR of substantial areas of
lowland plains, high human disturbance, and non-forest habitat, which
provide no suitable habitat for takin. According to our results,
suitable takin habitat covered 18.97% of the CDR, suggesting a
substantially over-estimated distribution. However, there are high
proportions of habitat (40%) still covered by the nature reserve
network, indicating the importance of protected areas (PAs) in
conservation threaten species. We recommend that experts apply the basic
approach presented herein to update the Red List distributions for more
species to increase the accuracy of assessments and resulting
conservation applications.
Fungal exposome, human health and unmet needs: a 2022 update with special focus on allergy
Authors: Vitte Joana , Michel Moïse , Malinovschi Andrei , Caminati Marco , Odebode Adeyinka , Annesi-Maesano Isabella , Caimmi Davide , Cassagne Carole , Demoly Pascal , Heffler Enrico , Menu Estelle , Nwaru Bright , Sereme Youssouf , Ranque Stéphane , Raulf Monika , Feleszko Wojciech , Janson Christer , Galán Carmen
Published: March 2022

Humans inhale, ingest and touch thousands of fungi each day. The
ubiquity and diversity of the fungal kingdom are in sharp contrast with
their complex and relatively blurred taxonomy and scarce knowledge about
their distribution, pathogenic effects, and effective interventions at
the environmental and individual levels. Here, we present an overview of
salient features of fungi as permanent players of the human exposome and
key determinants of human health. Improved understanding of the fungal
exposome sheds new light on the epidemiology of fungal-related diseases,
their immunological substratum, the currently available methods, and
biomarkers for environmental and medical fungi. Unmet needs are
described and potential approaches are highlighted as perspectives.
Microclimatic variations in tropical canopies: a glimpse into the processes of community assembly in epiphytic bryophyte communities
Authors: Shen Ting , Corlett Richard , Collart Flavien , Kasprzyk Thibault , Guo Xin-Lei , Patiño Jairo , Su Yang , Hardy Olivier , Ma Wen-Zhang , Wang Jian , Wei Yu-Mei , Mouton Léa , Li Yuan , Song Liang , Vanderpoorten Alain
Published: March 2022

Epiphytic communities live in a unique, three-dimensional micro-habitat
space that offers an original framework to disentangle the contribution
of environmental filters, biotic interactions and dispersal limitation
to community structure at small spatial scales. We took advantage of a
tropical canopy crane facility to record and model spatio-temporal
microclimatic variation and assess its impact on the composition and
phylogenetic structure of epiphytic bryophyte communities. Generalized
Dissimilarity Modelling evidenced the crucial role of microclimates in
determining the composition of moss and liverwort communities. The shift
between negative or non-significant phylogenetic turnover to
consistently significant clustering from the base to the canopy suggests
that phylogenetic constraints further contribute to shape the assembly
of epiphytic bryophyte communities. The slight, but significant
correlation between increasing phylogenetic clustering with variation in
microclimatic conditions adds to emerging evidence for the role of
environmental filtering upon community assembly, including at the small
spatial scales of epiphytic communities.
Generation of Synchronous Unpredictable Oscillations by Coupled Hopfield Neural Networks
Authors: Fen Mehmet Onur , Fen Fatma Tokmak
Published: March 2022

A new criterion based on generalized synchronization is provided for the
extension of unpredictable oscillations among coupled Hopfield neural
networks (HNNs). It is shown that if a drive HNN possesses an
unpredictable oscillation, then a response HNN also possesses such an
oscillation provided that they are synchronized in the generalized
sense. Extension of unpredictability in coupled 4D HNNs are exemplified
with simulations. The auxiliary system approach and conditional Lyapunov
exponents are utilized to demonstrate the presence of synchronization.
Blood Flow Restricted Walking in Elderly Individuals with Knee Osteoarthritis: A Feasibility Study
Authors: Petersson Naaja , Langgård Jørgensen Stian , Kjeldsen Troels , Mechlenburg Inger , Aagaard Per
Published: March 2022

Objective: To investigate whether blood flow restricted walking exercise is feasible in patients with knee osteoarthritis, and to examine changes in functional performance and self-reported function.Design: Feasibility study.Patients and methods: Fourteen elderly individuals diagnosed with knee osteoarthritis participated in 8–10 weeks of outdoor walking (4 km/h, 20 min/session, 4 times/week) with partial blood flow restriction applied to the affected leg. Adherence, dropouts and adverse events were registered. Timed Up and Go test, 30-s sit-to-stand performance, 40-m fast-paced walk speed, stair-climbing and Knee Osteoarthritis Outcome Score were assessed pre- and post-training.Results: Nine participants completed the intervention, while 5 participants withdrew (4 due to intervention-related reasons). In non-completing participants baseline body mass index (BMI) (p = 0.05) and knee pain (p = 0.06) were higher, while gait performance (p = 0.04) was lower. Considering completed case data, the training-adherence rate was 93%, while mean knee pain in the affected leg was 0.7 on a numerical rating scale of 0–10. Functional performance improved, while self-reported function remained unchanged.Conclusion: Blood flow restricted walking exercise appeared feasible in patients with knee osteoarthritis. Participants who completed the intervention protocol demonstrated improvements in functional performance, with no changes in self-reported function.
LAY ABSTRACTPatients with knee osteoarthritis typically experience knee joint pain and functional disability. Consequently, it is beneficial for these patients to engage in tolerable exercise programmes to enhance their functional performance. This study examined the feasibility of 8–10 weeks of blood flow restricted (BFR) walking exercise in patients with long-term knee osteoarthritis. The exercise programme was feasible, did not exacerbate knee pain or provoke cuff discomfort, and produced improved functional performance in those participants (9/14) who completed the intervention protocol (93% adherence rate). Notably however, 4 patients withdrew from the study due to intervention-related reasons. In this study, feasibility and adherence to BFR-walking appeared to depend on individual factors, with high body mass index, high perceived knee pain, and low baseline levels of fast-paced walking, predisposing to low adherence to training. Thus, these individual characteristics must be taken into account when administering BFR-walking exercise in patients with knee osteoarthritis.
PROFESSIONALITET (VOCATIONALITY) AS A MECHANISM FOR SYNCHRONIZING SECONDARY VOCATIONAL EDUCATION SYSTEM AND LABOUR MARKET
Authors: LISTVIN ALEXANDER A. , GARTH MARINA A.
Published: March 2022

The authors consider the staffing problem in sectors of the economy based on the interaction of secondary vocational education institutions and employers. It is noted that a system of institutional and economic conditions has not yet been established to attract enterprises to train qualified personnel for their needs. The search for an effective mechanism for synchronizing the capabilities of the secondary vocational education system and the needs of the labor market has resulted in the development of the project - “Professionalitet (vocationality)”. The article assesses its necessity, conditions and possibilities of implementation.