bluuebunny/crossref_metadata_2025 huggingface dataset:
Top-Down Cortical Control of Acute and Chronic Pain
Authors: Urien Louise , Wang Jing
Published: October 2019

Acute pain has an evolutionary role in the detection of physical harm and the response to it. In some cases, however, acute pain can impair function and lead to other morbidities. Chronic pain, meanwhile, can present as a psychopathological condition that significantly interferes with daily living. Most basic and translational pain research has focused on the molecular and cellular mechanisms in the spinal and peripheral nervous systems. In contrast, the brain plays a key role in the affective manifestation and cognitive control of pain. In particular, several cortical regions, such as the somatosensory cortex, prefrontal cortex, insular, and anterior cingulate cortex, are well known to be activated by acute pain signals, and neurons in these regions have been demonstrated to undergo changes in response to chronic pain. Furthermore, these cortical regions can project to a number of forebrain and limbic structures to exert powerful top-down control of not only sensory pain transmission but also affective pain expression, and such cortical regulatory mechanisms are particularly relevant in chronic pain states. Newer techniques have emerged that allow for detailed studies of central pain circuits in animal models, as well as how such circuits are modified by the presence of chronic pain and other predisposing psychosomatic factors. These mechanistic approaches can complement imaging in human studies. At the therapeutic level, a number of pharmacological and nonpharmacological interventions have recently been shown to engage these top-down control systems to provide analgesia. In this review, we will discuss how pain signals reach important cortical regions and how these regions in turn project to subcortical areas of the brain to exert profound modulation of the pain experience. In addition, we will discuss the clinical relevance of such top-down pain regulation mechanisms.
An Aplasia Cutis Congenita: Suggestion of Management Algorithm
Authors: Lee Yeon Ji , Kim Seong Ae , Moon Suk-Ho
Published: October 2019

Background:

When a child is born with Aplasia cutis congenita (ACC), it is important for the surgeon to decide promptly whether to perform early surgical intervention, or proceed with conservative care. Several patients of ACC have been reported in which various treatments have attempted. However, the criteria of treatment remain controversial. In this study, the authors present an algorithm and the literature review to assist with objective decisions during ACC management.

Methods:

A total of 4 cases of infants born with ACC were referred to our department between January 2017 and April 2019. Conservative care was to be considered a first choice of management.

Results:

The ACC lesions were presented in the scalp vertex area in all 4 infants with the intact dura mater. There was no large vein exposure or sagittal sinus exposure in all infants. All 4 infants were managed with conservative care, which immediately resulted in complete healing of the defects without any complications.

Conclusions:

Rapid decision-making is required whether or not the patient requires emergency surgical coverage. Even extensive defects may be healed by conservative care alone, if the dura mater is intact and accompanying large vein or sagittal sinus exposure is not identified.
Sound generation due to the interaction of turbulence with surfaces embedded in transversely sheared flow
Authors: Goldstein M. E. , Leib S. J. , Afsar M. Z.
Published: October 2019

This paper reviews the application of Rapid Distortion Theory (RDT) on transversely shear mean flows to the prediction of sound generated from solid surfaces imbedded in turbulent shear flows. This phenomenon is relevant to the so-called installation noise problem which has received considerable attention in recent years. A few representative results from applications that have appeared in the literature are also presented.

This article is part of the theme issue ‘Frontiers of aeroacoustics research: theory, computation and experiment’.
First-principle description of acoustic radiation of shear flows
Authors: Wu Xuesong , Zhang Zhongyu
Published: October 2019

As a methodology complementary to acoustic analogy, the asymptotic approach to aeroacoustics seeks to predict aerodynamical noise on the basis of first principles by probing into the physical processes of acoustic radiation. The present paper highlights the principal ideas and recent developments of this approach, which have shed light on some of the fundamental issues in sound generation in shear flows. The theoretical work on sound wave emission by nonlinearly modulated wavepackets of supersonic and subsonic instability modes in free shear flows identifies the respective physical sources or emitters. A wavepacket of supersonic modes is itself an efficient emitter, radiating directly intensive sound in the form of a Mach wave beam, the frequencies of which are in the same band as those of the modes in the packet. By contrast, a wavepacket of subsonic modes radiates very weak sound directly. However, the nonlinear self-interaction of such a wavepacket generates a slowly modulated mean-flow distortion, which then emits sound waves with low frequencies and long wavelengths on the scale of the wavepacket envelope. In both cases, the acoustic waves emitted to the far field are explicitly expressed in terms of the amplitude function of the wavepacket. The asymptotic approach has also been applied to analyse generation of sound waves in wall-bounded shear flows on the triple-deck scale. Several subtleties have been found. The near-field approximation has to be worked out to a sufficiently higher order in order just to calculate the far-field sound at leading order. The back action of the radiated sound on the flow in the viscous sublayer and the main shear layer is accounted for by an impedance coefficient. This effect is of higher order in the subsonic regime, but becomes a leading order in the transonic and supersonic regimes.

This article is part of the theme issue ‘Frontiers of aeroacoustics research: theory, computation and experiment’.
ICTV Virus Taxonomy Profile: Paramyxoviridae
Authors: Rima Bert , Balkema-Buschmann Anne , Dundon William G. , Duprex Paul , Easton Andrew , Fouchier Ron , Kurath Gael , Lamb Robert , Lee Benhur , Rota Paul , Wang Linfa ,   ICTV Report Consortium
Published: October 2019

The family Paramyxoviridae consists of large enveloped RNA viruses infecting mammals, birds, reptiles and fish. Many paramyxoviruses are host-specific and several, such as measles virus, mumps virus, Nipah virus, Hendra virus and several parainfluenza viruses, are pathogenic for humans. The transmission of paramyxoviruses is horizontal, mainly through airborne routes; no vectors are known. This is a summary of the current International Committee on Taxonomy of Viruses (ICTV) Report on the family Paramyxoviridae. which is available at ictv.global/report/paramyxoviridae.
High-amplitude co-fluctuations in cortical activity drive functional connectivity
Authors: Esfahlani Farnaz Zamani , Jo Youngheun , Faskowitz Joshua , Byrge Lisa , Kennedy Daniel P. , Sporns Olaf , Betzel Richard F.
Published: October 2019

Resting-state functional connectivity is used throughout neuroscience to study brain organization and to generate biomarkers of development, disease, and cognition. The processes that give rise to correlated activity are, however, poorly understood. Here, we decompose resting-state functional connectivity using a “temporal unwrapping” procedure to assess the contributions of moment-to-moment activity co-fluctuations to the overall connectivity pattern. This approach temporally resolves functional connectivity at a timescale of single frames, which enables us to make direct comparisons of co-fluctuations of network organization with fluctuations in the BOLD time series. We show that, surprisingly, only a small fraction of frames exhibiting the strongest co-fluctuation amplitude are required to explain a significant fraction of variance in the overall pattern of connection weights as well as the network’s modular structure. These frames coincide with frames of high BOLD activity amplitude, corresponding to activity patterns that are remarkably consistent across individuals and identify fluctuations in default mode and control network activity as the primary driver of resting-state functional connectivity. Finally, we demonstrate that co-fluctuation amplitude synchronizes across subjects during movie-watching and that high-amplitude frames carry detailed information about individual subjects (whereas low-amplitude frames carry little). Our approach reveals fine-scale temporal structure of resting-state functional connectivity, and discloses that frame-wise contributions vary across time. These observations illuminate the relation of brain activity to functional connectivity and open a number of new directions for future research.
A conveyor feeder for animal experiments
Authors: Oh Jinook
Published: October 2019

Several different types of open source feeders have been used in animal experiments in cognitive biology, neuroscience, psychology and related fields. These feeders use either dry pellets, which have hard surface and simple shape, or liquid food types such as sucrose solution. These food types can be rather easily manipulated due to its physical attributes. Although it is beneficial in terms of controllability, animal subjects often lose motivation to interact with operant conditioning devices offering such food items. Using natural food items such as fruits, insects, worms and pieces of meat will be helpful to keep the subject’s motivation high, however, those food items are not very well suited for currently available open source feeders due to its physical attributes, including its complex shape, sticky and delicate texture. We made a feeder to deliver such natural food items to animal subjects for operant conditioning, using relatively cheap and easily obtainable parts. For a validation, we built a full operant conditioning device for wolves and dogs, containing two of these feeders, a pressure-sensitive monitor and a speaker.

Specifications table
The neural signature of numerosity: Separating numerical and continuous magnitude extraction in early visual cortex with frequency-tagged EEG
Authors: Van Rinsveld Amandine , Guillaume Mathieu , Kohler Peter J. , Schiltz Christine , Gevers Wim , Content Alain
Published: October 2019

The ability to handle approximate quantities, or number sense, has been recurrently linked to mathematical skills, though the nature of the mechanism allowing to extract numerical information (i.e., numerosity) from environmental stimuli is still debated. A set of objects is indeed not only characterized by its numerosity but also by other features, such as the summed area occupied by the elements, which often covary with numerosity. These intrinsic relations between numerosity and non-numerical magnitudes led some authors to argue that numerosity is not independently processed but extracted through a weighting of continuous magnitudes. This view cannot be properly tested through classic behavioral and neuroimaging approaches due to these intrinsic correlations. The current study used a frequency-tagging EEG approach to separately measure responses to numerosity as well as to continuous magnitudes. We recorded occipital responses to numerosity, total area, and convex hull changes but not to density and dot size. We additionally applied a model predicting primary visual cortex responses to the set of stimuli. The model output was closely aligned with our electrophysiological data, since it predicted discrimination only for numerosity, total area, and convex hull. Our findings thus demonstrate that numerosity can be independently processed at an early stage in the visual cortex, even when completely isolated from other magnitude changes. The similar implicit discrimination for numerosity as for some continuous magnitudes, which correspond to basic visual percepts, shows that both can be extracted independently, hence substantiating the nature of numerosity as a primary feature of the visual scene.
Global brain signal in awake rats
Authors: Ma Yuncong , Ma Zilu , Liang Zhifeng , Neuberger Thomas , Zhang Nanyin
Published: October 2019

Although often used as a nuisance in resting-state functional magnetic resonance imaging (rsfMRI), the global brain signal in humans and anesthetized animals has important neural basis. However, our knowledge of the global signal in awake rodents is sparse. To bridge this gap, we systematically analyzed rsfMRI data acquired with a conventional single-echo (SE) echo planar imaging (EPI) sequence in awake rats. The spatial pattern of rsfMRI frames during peaks of the global signal exhibited prominent co-activations in the thalamo-cortical and hippocampo-cortical networks, as well as in the basal forebrain, hinting that these neural networks might contribute to the global brain signal in awake rodents. To validate this concept, we acquired rsfMRI data using a multi-echo (ME) EPI sequence and removed non-neural components in the rsfMRI signal. Consistent co-activation patterns were obtained in extensively de-noised ME-rsfMRI data, corroborating the finding from SE-rsfMRI data. Furthermore, during rsfMRI experiments we simultaneously recorded neural spiking activities in the hippocampus using GCaMP-based fiber photometry. The hippocampal calcium activity exhibited significant correspondence with the global rsfMRI signal. These data collectively suggest that the global rsfMRI signal contains significant neural components that involve coordinated activities in the thalamo-cortical and hippocampo-cortical networks. These results provide important insight into the neural substrate of the global brain signal in awake rodents.
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
Authors: Engelbrecht Eric , Levesque Michel V. , He Liqun , Vanlandewijck Michael , Nitzsche Anja , Kuo Andrew , Singh Sasha A. , Aikawa Masanori , Holton Kristina , Proia Richard L , Kono Mari , Pu William T. , Camerer Eric , Betsholtz Christer , Hla Timothy
Published: October 2019

Despite the medical importance of G protein-coupled receptors (GPCRs), in vivo cellular heterogeneity of GPCR signaling and downstream transcriptional responses are not understood. We report the comprehensive characterization of transcriptomes (bulk and single-cell) and chromatin domains regulated by sphingosine 1-phosphate receptor-1 (S1PR1) in adult mouse aortic endothelial cells. First, S1PR1 regulates NFkB and nuclear glucocorticoid receptor pathways to suppress inflammation-related mRNAs. Second, spatially distinct S1PR1 signaling in the aorta is associated with heterogenous endothelial cell (EC) subtypes. For example, a transcriptomically distinct arterial EC population at vascular branch points (aEC1) exhibits ligand- independent S1PR1/ß-arrestin coupling. In contrast, circulatory S1P-dependent S1PR1/ß-arrestin coupling was observed in non-branch point aEC2 cells that exhibit an inflammatory signature. Moreover, an adventitial lymphatic EC (LEC) population shows suppression of lymphangiogenic and inflammation-related transcripts in a S1P/S1PR1-dependent manner. These insights add resolution to existing concepts of GPCR signaling and S1P biology.
Orbitofrontal-striatal potentiation underlies stimulant induced hyperactivity
Authors: Bariselli Sebastiano , Miyazaki Nanami , Kravitz Alexxai
Published: October 2019

Stimulants are one of the most widely prescribed classes of pharmaceuticals, but it is unclear which brain pathways underlie their therapeutic and adverse actions. Here, with real-time monitoring of circuit plasticity, we demonstrate that psychostimulants strengthen orbitofrontal (OFC) to dorsomedial striatum (DMS) pathway synapses, and increase striatal output in awake mice. In vivo high-frequency stimulation of OFC-DMS pathway blocked stimulant-induced potentiation and the expression of locomotor sensitization, thereby directly linking OFC-DMS plasticity to hyperactivity.
Using a Motion Sensor to Categorize Low Back Pain Patients: A Machine Learning Approach
Authors: Abdollahi Masoud , Ashouri Sajad , Abedi Mohsen , Azadeh-Fard Nasibeh , Parnianpour Mohamad , Rashedi Ehsan
Published: October 2019

Low back pain (LBP) remains a critical health issue impacting literally millions of people worldwide. Currently, clinical practitioners rely on subjective measures such as the STarT Back Screening Tool to categorize LBP patients, which then informs specific treatment regimens. This study sought to develop a machine learning model to classify LBP patients into different groups according to kinematic data. Specifically, an inertial measurement unit (IMU) was attached to each patient’s chest while he performed trunk flexion/extension motions at a self-selected pace. Machine learning algorithms such as support vector machine (SVM) and multi-layer perceptron (MLP) were implemented to evaluate the efficiency of the models. The results showed that the kinematic data we obtained could be used to categorize the patients into two groups: high vs. low-medium risk. We achieved accuracy levels of ~75% and 60% for SVM and MLP, respectively. Additionally, among a range of variables detailed herein, we determined that time-scaled IMU signal resulted in the highest accuracy. Our findings support the use of body-motion measures in developing prognosis tools for healthcare applications. Our results could help overcome the need for objective clinic-based diagnosis approaches, which in turn would lead to assigning better treatment approaches and rehabilitation services for LBP sufferers.
Characterization of vertically and cross-species transmitted viruses in the cestode parasiteSchistocephalus solidus
Authors: Hahn Megan A , Rosario Karyna , Lucas Pierrick , Dheilly Nolwenn M
Published: October 2019

Parasitic flatworms (Neodermata) represent a public health and economic burden due to associated debilitating diseases and limited therapeutic treatments available. Despite their importance, there is scarce information regarding flatworm-associated microbes. We report the discovery of six RNA viruses in the cestodeSchistocephalus solidus. None were closely related to classified viruses and they represent new taxa. Mining transcriptomic data revealed the broad distribution of these viruses in Alaskan and EuropeanS. soliduspopulations. We demonstrate throughin vitroculture ofS. solidusthat five of these viruses are vertically transmitted. With experimental infections and field-sampling, we show that one of the viruses is transmitted to parasitized hosts. The impact of these viruses in parasite fitness and pathogenicity, and in host-parasite co-evolutionary dynamics remains to be determined. The detection of six novel viruses in this first characterization of viruses in Neodermatans likely represents a fraction of virus diversity in parasitic flatworms.
Heterochronically expressed midline netrin was recruited to guide mesoderm migration in epibolic gastrulation of the leech
Authors: Lee Jun-Ru , Kuo Dian-Han
Published: October 2019

Netrin is a remarkably conserved midline landmark, serving as a chemotactic factor that organizes the bilateral neural architecture in the post-gastrula bilaterian embryos. Netrin signal also guides cell migration in many other neural and non-neural organogenesis events in later developmental stages, but it has never been before found to participate in gastrulation – the earliest cell migration in metazoan embryogenesis. Here, we found that netrin signaling molecules and their receptors are expressed during gastrulation of the leechHelobdella. Intriguigly,Hau-netrin-1was expressed in the N lineage, the precursor of ventral ectoderm, at the onset of gastrulation. We demonstrated that the N lineage is required for the entrance of mesoderm into the germinal band and that misexpression of Hau-netrin-1 in early gastrulation prevented mesoderm from entering the germinal band. Together, these results suggested that Hau-netrin-1 secreted by the N lineage guides mesoderm migration during germinal band assembly. Furthermore, ectopic expression of Hau-netrin-1 after the completion of germinal band assembly disrupted the epibolic migration of the germinal bands in a later stage of gastrulation. Thus, Hau-netrin-1 is likely involved in two distinct events in sequential stages of leech gastrulation: the assembly of germinal bands in early gastrulation and their epibolic migration in mid-gastrulation. This mode of gastrulation as observed in the leech is apomorphic for clitellate annelids. We postulated that a heterochronic shift of netrin gene expression in the clitellate ancestor might have facilitated the evolutionary emergence of a novel form of gastrulation in this lineage.
Identification and comparison of genes differentially regulated by transcription factors and miRNAs
Authors: Asiaee Amir , Abrams Zachary B , Nakayiza Samantha , Sampath Deepa , Coombes Kevin R.
Published: October 2019

Transcription factors and microRNAs (miRNA) both play a critical role in gene regulation and in the development of many diseases such as cancer. Understanding how transcription factors and miRNAs influence gene expression is thus important to understand, but complicated due to the large and interconnected nature of the human genome. To help better understand what genes are being regulated by transcription factors and/or miRNAs we looked at it over 8000 patient samples from 32 different cancer types collected from The Cancer Genome Atlas (TCGA). We started by clustering the transcription factors and miRNAs using Thresher to reduce the number of features. Using both the mRNA and miRNA sequencing data we constructed linear models to calculate the coefficient of determination (R2) for each mRNA based on the Thresher cluster expression. We generated three types of linear models: transcription factor, miRNA and transcription factor plus miRNA. We then determined genes that were highly explained or poorly explained by each of the three models based on the genes R2 value. We performed downstream gene enrichment analysis using ToppGene on the sets of well and poorly explained genes. This identified differences in gene regulation between transcription factors and miRNAs and showed what groups of gene are differentially regulated.
Qualitative study of challenges and strategies of Indian IT organizations toward global branding
Authors: Ray Keshab , Sharma Meenakshi
Published: October 2019

Purpose

There is a lacuna in research work in terms of understanding how Indian IT organizations can become global brands. Benchmarking has not received much attention in marketing literature due to lack of benchmarking framework, and IT organizations are yet to make progress in benchmarking. The purpose of this paper is to examine the impact of brand strength on global branding by developing a conceptual benchmarking framework for Indian IT organizations.

Design/methodology/approach

Semi-structured in-depth interviews are conducted with thirty middle-level managers from two Indian IT organizations, two US-based global IT organizations and one UK-based leading bank, which is a customer of these IT organizations.

Findings

Results show a positive relationship between brand strength and global branding, between customer loyalty and global branding, between brand loyalty and competitive advantage and between global branding and competitive advantage. Indian IT organizations can benchmark global IT organizations to improve delivering brand promise, positioning, awareness building and authenticity toward making Indian IT organizations future ready to address the entire breadth of opportunities in the evolving world of cloud and digital.

Practical implications

This research helps managers with a brand strength-based benchmarking framework toward global branding of Indian IT organizations.

Social implications

IT is instrumental for rapid growth of Indian’s economy. India should optimally utilize its greatest wealth, its human potential, with the latent global demand in IT through building global IT brands.

Originality/value

The originality of the study lies in conducting a qualitative study on global branding of Indian IT organizations and also proposing a conceptual benchmarking framework. The study further validates the model using qualitative analysis.
Innovative solutions to increase last-mile delivery efficiency in B2C e-commerce: a literature review
Authors: Mangiaracina Riccardo , Perego Alessandro , Seghezzi Arianna , Tumino Angela
Published: October 2019

Purpose

The purpose of this paper is twofold: first, to review and classify scientific publications dealing with those innovative solutions aimed at increasing the efficiency of last-mile delivery in business to consumer (B2C) e-commerce; and, second, to outline directions for future research in this field.

Design/methodology/approach

The review is based on 75 papers published between 2001 and 2019 in international peer-reviewed journals or proceedings of conferences, retrieved from bibliographic databases and science search engines.

Findings

Due to its importance in affecting the overall logistics costs and, as a consequence, the economic sustainability of a B2C e-commerce initiative, last-mile delivery process deserves particular attention in order to be optimised. The review highlights that, among the main factors affecting its cost, there are the probability to have failed deliveries, the customer density in the delivery areas and the degree of automation of the process. Innovative and viable last-mile delivery solutions – which may impact the mentioned drivers – include parcel lockers, crowdsourcing logistics, mapping the consumer presence at home and dynamic pricing policies. Eventually, some gaps and areas for further research activities have been identified (e.g. mapping customer behaviour, crowdsourcing logistics).

Originality/value

This review offers interesting insights to both academics and practitioners. On the academic side, it analyses and classifies relevant literature about innovative and efficiency-oriented last-mile delivery solutions, proposing directions for future research efforts. On the managerial side, it presents a holistic framework of the main factors affecting last-mile delivery cost and of viable innovative solutions that may be implemented to increase efficiency.
High school students’ role-playing for identity exploration: findings from virtual city planning
Authors: Foster Aroutis , Shah Mamta , Barany Amanda , Talafian Hamideh
Published: October 2019

Purpose

This paper aims to report findings for the following question, “What is the nature of high school students’ identity exploration as a result of exploring the role-possible selves of an environmental scientist and urban planner in a play-based course?” Projective reflection (PR) is served as a theoretical and methodological framework for facilitating learning as identity exploration in play-based environments.

Design/methodology/approach

From 2016-2017, 54 high school freshmen students engaged in virtual city planning, an iteratively refined course that provided systematic and personally relevant opportunities for play, curricular, reflection and discussion activities in Philadelphia Land Science, a virtual learning environment (VLE) and in an associated curriculum enacted in a science museum classroom. Participants’ identity exploration was anchored in targeted role-possible selves in science, technology, engineering and mathematics: environmental science and urban planning through in-game and in-class activities. This role-playing was made intentional by scaffolding students’ reflection on what they wanted to be in the future while thinking of their current selves and exploring novel role-possible selves.

Findings

In-game logged data and in-class student data were examined using quantitative ethnography (QE) techniques such as epistemic network analysis. Whole-group statistical significance and an illustrative case study revealed visual and interpretive patterns of change in students’ identity exploration. The change was reflected in their knowledge, interest and valuing, self-organization and self-control and self-perception and self-definition (KIVSSSS) in relation to the roles explored from the start of the intervention (starting self), during (exploring role-possible selves) and the end (new self). The paper concludes with directions to advance research on leveraging role-playing as a mechanism for fostering identity exploration in play-based digital and non-digital environments.

Originality/value

This paper leveraged VLEs such as games as forms of play-based environments that can present players with opportunities for self-transformation (Foster, 2014) and enculturation (Gee 2003; Shaffer, 2006) to support learner agency and participation in a constantly changing society (Thomas and Brown 2011). The authors introduce and apply novel theoretical and methodological approaches to the design and assessment of play-based environments and address pertinent gaps in the emergent area of learning and identity in VLEs
Investigation of normal and tangential contact stiffness considering surface asperity interaction
Authors: Yang Hongping , Che Xiaowei , Yang Cheng
Published: October 2019

Purpose

This paper aims to propose a normal and tangential contact stiffness model to investigate the contact characteristics between rough surfaces of machined joints based on fractal geometry and contact mechanics theory considering surface asperities interaction.

Design/methodology/approach

The fractal geometry theory describes surface topography and Hertz contact theory derives the asperities elastic, elastic-plastic and plastic contact deformation. The joint normal and tangential contact stiffness are obtained. The experiment method for normal and tangential contact stiffness are introduced.

Findings

The relationship between dimensionless normal contact load and dimensionless normal and tangential contact stiffness are analyzed in different plasticity index. The results show that they are nonlinear relationships. The normal and tangential contact stiffness are obtained based on theoretical and experimental methods for milling and grinding machined specimens. The results indicate that the present model for the normal and tangential contact stiffness are consistent with experimental data, respectively.

Originality/value

The normal and tangential contact stiffness models are constructed by using the fractal geometry and the contact mechanics theory considering surface asperities interaction, which includes fully elastic, elastic-plastic and fully plastic contacts deformation. The present method can generate a more reliable calculation result as compared with the contact model no-considering asperities interaction.
Motives to participate in an online community for professionals
Authors: Imroz Sohel M.
Published: October 2019

Purpose

Although the numbers of online community members continue to increase every day, most of the user-generated content in online communities comes from only a small percentage of members who are motivated to participate and contribute. While studies have been conducted on other professional online communities (e.g. teachers, mathematics practitioners, software developers, etc.), the online community for ServiceNow practitioners is not fully understood. Studies of this group could be useful to organizations that seek to understand ServiceNow practitioners’ motives to participate in these communities, fulfill their specific needs, and build and maintain a thriving community of users.

Design/methodology/approach

A qualitative case study method was used to learn what motivates ServiceNow practitioners to contribute and participate in ServiceNow communities. Data were collected from interviews with the participants, their stories and testimonials and physical artifacts created and used by them. Data analysis was carried out using data triangulation and continuous coding process.

Findings

Three primary motives were identified: find answers to questions or issues, learn about ServiceNow products and services, and share knowledge and expertise with others.

Research limitations/implications

As a single-case research method was used, findings of this study may not be generalized to a larger population.

Originality/value

Results should encourage and increase participation by ServiceNow Community's members, create a repository of knowledge and relationships that can improve their value and effectiveness, and help their organizations maintain competitive advantage.
Internal marketing, organizational commitment, and job performance in sport and leisure services
Authors: Chiu Weisheng , Won Doyeon , Bae Jung-sup
Published: October 2019

Purpose

The purpose of this paper is to propose a conceptual model and to investigate the relationships among internal marketing, organizational commitment and job performance in sport and fitness services.

Design/methodology/approach

Data were collected using a questionnaire survey from 254 employees at each of 12 municipal sport centers in Taipei City and were analyzed primarily using structural equation modeling techniques.

Findings

The results indicated that internal marketing has positive effects on organizational commitment and job performance. Moreover, organizational commitment has a positive influence on job performance and plays a partial mediating role in the relationship between internal marketing and job performance. The findings identify the relationships among internal marketing, organizational commitment and job performance.

Originality/value

This study proposed and tested an empirical model linking internal marketing, organizational commitment and job performance in sport and fitness services. Moreover, this study further probed into the path of influence of internal marketing strategies on job performance of employees by including their organizational commitment in the mediating process. The findings of this study have insightful implications and emphasize the important role of internal marketing in the management of customer service in sports.
Do CEO incentives and characteristics influence corporate social responsibility (CSR) and vice versa? A literature review
Authors: Velte Patrick
Published: October 2019

Purpose

This paper aims to analyze whether chief executive officer (CEO) incentives and characteristics (e.g. CEO power, CEO tenure) are linked with corporate social responsibility (CSR) and vice versa.

Design/methodology/approach

Based on upper echelons theory, the author conducts a structured literature review and evaluates 84 empirical-quantitative studies on CEO and CSR variables.

Findings

While the majority of the included studies analyzed the CEO-CSR link, there are indicators for a bidirectional relationship. Moreover, prior research has focused on CEO incentives, especially compensation contracts, and on the US capital market. A major research gap relates to CEO characteristics, e.g. CEO values, education and experience.

Research limitations/implications

Heterogeneous CEO and CSR variables and endogeneity concerns lower the validity of recent studies. Future research is encouraged to implement dynamic regression models, increase CSR and CEO proxies and focus on international samples with country-specific effects.

Practical implications

As CEO activities can have a major impact on CSR activities, the author recommends firms to search for opportunities to make their CSR strategy more comprehensive by their stakeholder communication, thus providing deeper insights into their CSR performance in line with stakeholders’ interests.

Originality/value

The paper is the first literature review on the interaction between CEO and CSR so far. The author explains the main CEO and CSR variables that have been included in research, stresses the limitations of the studies and gives useful recommendations for future research, practice and regulators.
Lysine acetylation contributes to development, aflatoxin biosynthesis and pathogenicity in Aspergillus flavus
Authors: Yang Guang , Yue Yuewei , Ren Silin , Yang Mingkun , Zhang Yi , Cao Xiaohong , Wang Yinchun , Zhang Jia , Ge Feng , Wang Shihua
Published: October 2019

Aspergillus flavus is a pathogenic fungus that produces carcinogenic aflatoxins, posing a great threat to crops, animals and humans. Lysine acetylation is one of the most important reversible post‐translational modifications and plays a vital regulatory role in various cellular processes. However, current information on the extent and function of lysine acetylation and aflatoxin biosynthesis in A. flavus is limited. Here, a global acetylome analysis of A. flavus was performed by peptide pre‐fractionation, pan‐acetylation antibody enrichment and liquid chromatography–mass spectrometry. A total of 1313 high‐confidence acetylation sites in 727 acetylated proteins were identified in A. flavus. These acetylation proteins are widely involved in glycolysis/gluconeogenesis, pentose phosphate pathway, citric acid cycle and aflatoxin biosynthesis. AflO (O‐methyltransferase), a key enzyme in aflatoxin biosynthesis, was found to be acetylated at K241 and K384. Deletion of aflO not only impaired conidial and sclerotial developments, but also dramatically suppressed aflatoxin production and pathogenicity of A. flavus. Further site‐specific mutations showed that lysine acetylation of AflO could also result in defects in development, aflatoxin production and pathogenicity, suggesting that acetylation plays a vital role in the regulation of the enzymatic activity of AflO in A. flavus. Our findings provide evidence for the involvement of lysine acetylation in various biological processes in A. flavus and facilitating in the elucidation of metabolic networks.
In Ganoderma lucidum, Glsnf1 regulates cellulose degradation by inhibiting GlCreA during the utilization of cellulose
Authors: Hu Yanru , Xu Wenzhao , Hu Shishan , Lian Lingdan , Zhu Jing , Shi Liang , Ren Ang , Zhao MingWen
Published: October 2019

Cellulose is a by‐product of agricultural production and an abundant waste. As a carbon source, cellulose can be degraded and utilized by fungi. Carbon sources, which act as nutrients, not only provide energy but also serve as regulators of gene expression, metabolism and growth, through various signalling networks that enable cells to sense and adapt to varying environmental conditions. Nutrient‐sensing pathways prioritize the use of preferred carbon sources and regulate the production of cellulose‐degrading enzymes when necessary. Understanding the regulation of the fungal cellulolytic response will become increasingly important because we strive to increase the efficiency of the utilization of these renewable energy sources. Here, we show that Glsnf1, a sucrose‐nonfermenting serine–threonine‐protein kinase 1 (Snf1)/AMP‐activated protein kinase homologue in medicinal macro basidiomycete Ganoderma lucidum, actively responds to carbon alterations and positively regulates cellulase activity and cellulase‐related gene transcription. The carbon catabolite repressor CreA, a zinc binuclear cluster transcription factor that mediates the sensing of nutrients and suppression of the transcription of a number of genes necessary for the consumption of a less preferred carbon source, participates in the Glsnf1‐mediated regulation of cellulases. Glsnf1 not only negatively regulates the transcription level of the CreA gene but also hinders its localization in the nucleus. Overall, our findings reveal a key nutrient‐sensing mechanism that is critical for the modulation of carbon source adaptation in G. lucidum.
The polyphagous plant pathogenic fungusBotrytis cinereaencompasses host‐specialized and generalist populations
Authors: Mercier Alex , Carpentier Florence , Duplaix Clémentine , Auger Annie , Pradier Jean‐Marc , Viaud Muriel , Gladieux Pierre , Walker Anne‐Sophie
Published: October 2019

The host plant is often the main variable explaining population structure in fungal plant pathogens, because specialization contributes to reduce gene flow between populations associated with different hosts. Previous population genetic analysis revealed that French populations of the grey mould pathogenBotrytis cinereawere structured by hosts tomato and grapevine, suggesting host specialization in this highly polyphagous pathogen. However, these findings raised questions about the magnitude of this specialization and the possibility of specialization to other hosts. Here we report specialization ofB.cinereapopulations to tomato and grapevine hosts but not to other tested plants. Population genetic analysis revealed two pathogen clusters associated with tomato and grapevine, while the other clusters co‐occurred on hydrangea, strawberry and bramble. Measurements of quantitative pathogenicity were consistent with host specialization of populations found on tomato, and to a lesser extent, populations found on grapevine. Pathogen populations from hydrangea and strawberry appeared to be generalist, while populations from bramble may be weakly specialized. Our results suggest that the polyphagousB.cinereais more accurately described as a collection of generalist and specialist individuals in populations. This work opens new perspectives for grey mould management, while suggesting spatial optimization of crop organization within agricultural landscapes.
Evaluation of California‐Grown Blood and Cara Cara Oranges Through Consumer Testing, Descriptive Analysis, and Targeted Chemical Profiling
Authors: Simons Tyler J. , McNeil Christopher J. , Pham Vi D. , Suh Joon Hyuk , Wang Yu , Slupsky Carolyn M. , Guinard Jean‐Xavier
Published: October 2019

The acceptability of Moro, Tarocco, Cara Cara, Shahani, Bream Tarocco, Boukhobza, and Sanguinelli oranges from both commercial and research orchards was tested with adult (n = 152) and child (n = 72) consumers. Qualitative focus groups were also conducted to understand consumer familiarity and thoughts about the fruit. Sensory descriptive and chemical analyses were carried out to identify drivers of liking. Overall, consumers preferred the lighter colored varieties consisting of Tarocco, Cara Cara, and Boukhobza. One cluster of adults (n = 80) showed preferences towards sweet and fruity flavors and away from sourness and citric acid. The second adult cluster (n = 72) was tolerant of the sour fruit but did not like fruit high in bitterness and flavonoid content. The largest child cluster (n = 42) showed preferences for samples higher in orange and tropical flavors (Cara Cara, Tarocco, and Boukhobza varieties). The appearance of the Cara Cara was strongly liked by the consumer population in both quantitative and qualitative settings. Hunter scale a color values strongly correlated to the higher berry/dried fruit flavors, and concentrations of naringenin. Focus group participants noted that they were relatively unfamiliar with blood oranges. Growers and producers may want to invest in the lighter colored varieties, such as Cara Cara, Tarocco, Boukhobza and Shahani, as these were liked by a majority of consumers and were low in less desirable sensory characteristics, such as bitterness and sourness.

Practical Application

Through consumer tests, sensory evaluation, and chemical analyses, this research uncovered which sensory properties may drive consumer acceptance of blood and Cara Cara oranges, and informed potential production and marketing strategies for increasing their consumption. This information should benefit the citrus industry as a whole and may enhance the use of specialty oranges by the food, beverage, and food service industries.
Ideas, Institutions and the World Bank: The Social Protection and Fragile States Agendas
Authors: Mackinder Sophie
Published: October 2019

Ideas and institutions are frequently used as explanatory concepts regarding policy development and change. There is an on‐going debate as to the explanatory weight that each should be afforded; Weiss and Carayannis (2001) identify a spectrum of opinions, with ‘institutionalist' approaches that embed ideas within institutionalist frameworks at one end, and ‘constructivist' approaches which argue that ideational concepts should be dis‐embedded from institutional considerations at the other. Drawing on 43 interviews with senior World Bank staff and a documentary analysis, this paper traces two policy agendas – social protection and fragile states – to identify the institutional and ideational features of the World Bank that a developmental agenda must navigate to achieve prominence in the Bank's work. It finds that the success of a policy agenda is determined by whether the ideas fit with a macro‐ideational dominant paradigm, and identifies several institutional features such as the incentive structure and lending mechanisms that influence an agenda's success.
Measuring News in Management Range Forecasts
Authors: Jensen Tyler K. , Plumlee Marlene A.
Published: October 2019

Management earnings forecasts expressed as a range have become the most common form of quantitative management guidance. Traditionally, the proxy for the sign and the magnitude of the information conveyed by these forecasts—the forecast news—is calculated as the difference between a pre‐forecast earnings expectation and the midpoint of the forecasted range. We provide strong evidence that this traditional measure understates the amount of information conveyed by range forecasts. More importantly, we demonstrate that information conveyed by the upper and lower bounds of the forecasts can be used to improve the classification of forecasts as conveying good or bad news and for calculating the magnitude of that news. We rely on these findings to suggest alternative methods of classifying management range forecasts as conveying good versus bad news and to refine the calculation of forecast news to include the broader information set. Our analysis also suggests that the information conveyed by the range when the forecasts are bundled (issued concurrent with an earnings announcement) is significantly different than when forecasts are not bundled. Overall, our study documents the importance of incorporating range‐related information when assessing the sign and the magnitude of the information conveyed by management range forecasts.