bluuebunny/crossref_metadata_2025 huggingface dataset:
Gambaran Pengobatan Terapi Obat Antituberkulosis (OAT) Pada Pasien TB Koinfeksi HIV Di RSUD Abepura Jayapura Papua
Authors: Anggraeni Nuniek , Nuryastuti Titik , Nurrochmad Arief
Published: October 2024

Tuberkulosis (TB) merupakan infeksi oportunistik yang banyak terjadi pada orang dengan HIV/AIDS, dan menjadi penyebab kematian utama. Pasien TB memerlukan terapi pemberian obat secara bersamaan dengan 4 macam obat Antituberkulosis (OAT), yang bila disertai dengan adanya koinfeksi HIV akan menambah jumlah pengobatan dengan ARV sehingga berisiko menyebabkan kegagalan terapi karena semakin banyak obat yang dikonsumsi dan dalam jangka waktu yang panjang. Tujuan penelitian ini untuk mengetahui gambaran terapi dan luaran klinik pada pasien TB koinfeksi HIV di RSUD Abepura Jayapura Papua. Analisis data dilakukan secara deskriptif menggunakan metode univariat meliputi data karakteristik subjek, gambaran penggunaan obat dan luaran klinik TB. Sampel terdiri dari 32 pasien TB koinfeksi HIV selama periode 1 Januari 2019 sampai dengan 31 Desember 2021 yang baru terdiagnosis TB dan HIV secara bersamaan, mendapat terapi OAT dan belum pernah mendapat terapi ARV sebelumnya. Kelompok pasien TB koinfeksi HIV lebih banyak ditemukan pada kelompok usia muda dan produktif 18-40 tahun (93,75%), laki-laki (68,75%), pasien yang bersekolah pada tingkat menengah atas (68,75%), pasien yang belum menikah (62,50%), tidak bekerja (56,25%), dan banyak terjadi pada suku papua (90,63%). Lokasi anatomi yang paling banyak terjadi pada paru (75%), sediaan OAT yang paling banyak digunakan dalam bentuk kombipak (84,38%), paduan OAT yang banyak digunakan RHZE (93,75%) dengan durasi 6-8 bulan (50%). Tingkat keberhasilan terapi mencapai 62,5% (pasien sembuh 21,88% dan pengobatan lengkap 40,62%), dengan pasien putus pengobatan 37,5%.
Potensi Cengkeh (Syzygium aromaticum (L.) Merr. & Perry) di Indonesia Sebagai Sumber Daya Alam dan Bahan Baku Obat Antibakteri dan Antijamur
Authors: Pradana Andi , Santosa Djoko , Sulaiman Teuku Nanda Saifullah
Published: October 2024

Popularitas tanaman sebagai penanganan infeksi mikroba kian meningkat. Cengkeh adalah tanaman dengan kandungan senyawa kimia utama eugenol yang dapat digunakan sebagai antibakteri. Review ini dibuat menggunakan data sekunder dari database literatur ilmiah PubMed, Scopus, Google Scholar, SINTA, dan Science-Direct yang bertujuan untuk melihat potensi dari ektrak etanol bunga, daun dan batang cengkeh sebagai agen antimikroba. Aktivitas antibakteri E. coli dari daun dan bunga secara berturut-turut 20% (14,6mm); 31,25% (14mm). Daya hambat terhadap bakteri S. aureus dari batang, daun, bunga secara berturut-turut 40% (21,5mm); 50% (14,66mm); 62,50% (5mm). Aktivitas antibakteri terhadap S. mutans dari bunga dan daun secara berturut-turut 40% (18,83mm); 40% (12mm). Aktivitas bunga cengkeh terhadap jamur C. albicans konsentrasi 12,5% (20mm) dan memiliki KHM 1 μL/mL (44mm).
Profil Penggunaan Granulocyte Colony Stimulating Factor (G-Csf) Pada Pasien Kanker Dengan Neutropenia di RSUP Dr. Kariadi Semarang
Authors: Ningsih Diana Rachma , Murwanti Retno , Nugroho Agung Endro
Published: October 2024

Kejadian neutropenia pada pasien kanker disebabkan 90% akibat kemoterapi. Penundaan pengatasan neutropenia dapat menyebabkan risiko terjadinya febril neutropenia sehingga menyebabkan tingginya mortalitas. Pasien kanker dengan neutropenia dapat diberikan terapi granulocyte colony stimulating factor (G-CSF), yang dapat mengurangi kejadian febril neutropenia, lama perawatan, menurunkan jumlah angka kesakitan dan kematian pada pasien kanker. Tujuan dari penelitian ini adalah mengetahui profil penggunaan G-CSF pada pasien kanker dengan neutropenia. G-CSF yang digunakan adalah Filgrastrim dan Lenograstrim. Penelitian ini menggunakan Retrospective Cohort Study dengan observational analitik yang dilaksanakan di RSUP Dr. Kariadi Semarang. Data penelitian dikumpulkan secara retrospektif menggunakan catatan medik pada periode 2019-2022. Sampel penelitian diperoleh 56 subyek yang memenuhi kriteria inklusi. Berdasarkan hasil penelitian pasien kanker dengan neutropenia  lebih banyak terjadi pada pasien kanker non hematologi sebesar (62,5%) dengan rentang usia paling banyak terjadi pada pada 18-60 tahun (78,6%). Grade neutropenia yang diamali pasien paling banyak yaitu neutropenia severe (55,3%), sedangkan pada neutropenia moderatre sejumlah (32,2%), dan neutropenia mild sebesar (12,5%). Profil penggunaan G-CSF pada pasien kanker dengan neutropenia di RSUP Dr. Kariadi yang diteliti yaitu Filgrastrim dan Lenograstrim. Pasien yang diberikan Filgrastrim sejumlah (73,2%) dan yang diberikan Lenograstrim sejumlah (26,8%).
Uji Toksisitas Akut Miristisin Terhadap Mencit Putih Betina (Mus musculus)
Authors: Putri Clara Prasidya Maharani , Ansory Hery Muhamad , Hanifah Inaratul Rizkhy
Published: October 2024

Miristisin memiliki aktivitas antidepresan, antioksidan, dan antibakteri, namun sampai saat ini belum ada data ilmiah mengenai toksisitas dari senyawa miristisin. Uji toksisitas akut oral dilakukan untuk mendeteksi efek toksik yang muncul dalam waktu singkat setelah pemberian sediaan uji.Tujuan penelitian ini adalah mengetahui toksisitas akut miristisin dari tanaman pala (Myristica fragrans) terhadap mencit putih betina (Mus musculus). Metode yang digunakan adalah fixed dose berdasarkan Organization for Economic Co-Operation and Development (OECD). Sampel pada penelitian ini adalah miristisin dari minyak pala dengan dosis 5, 50, 300 dan 2000 mg/KgBB. Hasil penelitian menunjukkan hingga dosis 2000 mg/KgBB tidak terdapat kematian namun pada dosis tersebut terdapat gejala toksisitas berupa grooming, lemas, dan nafas abnormal pada sebagian hewan uji sehingga miristisin dikatakan tidak toksik. Hasil analisis paired t test menunjukkan bahwa terdapat bermakna pada perubahan berat badan mencit antar kelompok pada hari pertama dan hari ke-3 pengamatan (p<0,05) yang diduga karena berkurangnya nafsu makan.
Evaluasi Perencanaan Dan Pengadaan Obat Di Dinas Kesehatan Kabupaten Kepahiang Pada Masa Pandemi Covid-19
Authors: Rabianti Lussi , Satibi Satibi , Puspandari Diah Ayu
Published: October 2024

Pengelolaan obat yang efektif dibutuhkan untuk menjamin ketersediaan, pemerataan dan keterjangkauan obat. Ketidaktepatan perencanaan dan hambatan pengadaan obat mengakibatkan masalah ketersediaan obat selalu terjadi pada tiap Kabupaten/Kota. Penelitian ini bertujuan untuk mengetahui gambaran perencanaan dan pengadaan obat di Dinas Kesehatan Kabupaten Kepahiang dan untuk mengetahui faktor-faktor yang mempengaruhi perencanaan dan pengadaan obat. Penelitian ini merupakan penelitian observasional deskriptif, dengan pendekatan kuantitatif-kualitatif terhadap 40 obat indikator nasional. Data kuantitatif diperoleh secara restrospektif melalui penelusuran dokumen pengelolaan obat tahun 2020-2021 dan dianalisis dengan membandingkan hasil pengukuran indikator dengan nilai standar. Data kualitatif diperoleh melalui observasi langsung dan wawancara mendalam yang dilakukan secara purposive sampling. Hasil penelitian menunjukkan dari enam indikator terdapat empat indikator yang belum memenuhi standar  yaitu indikator kesesuaian item dengan Fornas, kesesuaian dengan pola penyakit, ketepatan perencanaan, serta indikator kesesuaian permintaan. Faktor-faktor yang mempengaruhi perencanaan dan pengadaan obat yaitu ketidakjelasan koordinasi akibat belum optimalnya fungsi TPOT dan bagan struktur organisasi pengadaan, terbatasnya sumber daya manusia Kefarmasian dan tenaga yang bersertifikat pengadaan obat, inefisiensi anggaran pengadaan, serta belum optimalnya Sistem Informasi Manajemen (SIM).
Formulasi Krim Tabir Surya Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) Terenkapsulasi Nanopartikel Kitosan: Uji Aktivitas Secara In Vitro
Authors: Irianti Tatang
Published: October 2024

Hylocereus polyrhizus peel contains many flavonoid compounds that have potential to become sunscreen. Nanoparticle technology in sunscreen preparations has the advantage of increasing activation, surface area, and better diffusivity in protecting the skin. The purpose of this study was to identify the physical properties and determine the effectiveness of sunscreen cream with Ki-Ekubuname nanoparticles as an active substance. The ionic gelation method is used in the manufacture of nanoparticles by optimizing the speed and duration of stirring. Then made formulations with varying levels of active substance. Formulations were prepared with varying levels of the active substance (FA without active substance, FB with 6% Ekubuname, F1, F2, and F3 with 2%, 4%, and 6% Ki-Ekubuname, respectively). The creams formed were observed for physical, chemical properties and sunscreen activity with in vitro. The results showed that Ekubuname has a total flavonoids of 2.034 ± 0.094 mg QE/g. All sunscreen formulas with Ki-Ekubuname nanoparticle active substances meet SNI 16-4399-1996 standard. Nano-size active substances have better performance, as evidenced by higher SPF values. Formula F3 has the best characterization with a homogeneous appearance, light brown color, soft texture, distinctive aroma, pH 5, viscosity 4,768.25 ± 210.80 cps, adhesiveness 6.15 ± 0.25 seconds, spreadability 6.01 ± 0.10 cm, O/W cream type, and SPF value 17.41 (ultra protection category).
Evaluasi Perencanaan dan Distribusi Obat Program TB di Dinas Kesehatan Provinsi Maluku Utara
Authors: Carolin Marizka , Satibi Satibi , Puspandari Diah Ayu
Published: October 2024

Indonesia memiliki target eliminasi TB tahun 2030 dan bebas TB tahun 2050. Keberhasilan Program membutuhkan ketersediaan dan keterjangkauan Obat TB, sehingga diperlukan manajemen pengelolaan Obat TB yang baik. Tujuan penelitian ini untuk mengetahui alur dan evaluasi pada proses perencanaan dan distribusi obat program TB tahun 2022 di Dinas Kesehatan Provinsi Maluku Utara serta aspek pendukung dan penghambatnya. Penelitian ini bersifat deskriptif dengan pengamatan yang bersifat observasi dan wawancara. Data kuantitatif diperoleh secara retrospektif melalui penelusuran data dokumen perencanaan dan distribusi Obat Program TB tahun 2022. Data kualitatif diperoleh melalui wawancara secara mendalam kepada 4 informan yang menguasai perencanaan dan distribusi obat program TB yang dipilih secara purposive sampling. Analisis data kuantitatif yang diperoleh diukur menggunakan indikator perencanaan dan distribusi serta dibandingkan dengan hasil penelitian, data kualitatif dianalisis isi wawancara dan disajikan dalam bentuk narasi. Hasil evaluasi menunjukan ada 5 indikator yang tidak memenuhi standar yaitu ketepatan perencanaan (113%), penyimpangan perencanaan (44%), penyimpangan jumlah obat terdistribusi (0,3%), ITOR (1,33 kali) dan rata-rata waktu kekosongan obat (30 hari), sementara terdapat 5 indikator yang memenuhi standar yaitu ketersediaan obat (12,8 bulan), penataan obat (FEFO), obat terdistribusi seluruhnya ke Kabupaten/Kota (100%), nilai obat kadaluarsa dan stok obat mati (0%). Faktor penghambat keterlambatan pencairan dana distribusi dan dropping obat dari pusat. Faktor pendukung terdapat sistem informasi TB dan data pelaporan yang valid. Masih terdapat beberapa indikator yang perlu diperbaiki.
Analisis Penangkapan Radikal Bebas Jamu Rosella dan Fenolik Totalnya
Authors: Nurhaeni Farisya , Purwanto Purwanto , Irianto Iramie Duma Kencana , Fiqoh Latifah Nisa , Ardiyanti Febriana
Published: October 2024

Dengan semakin berkembangnya tingkat aktivitas manusia, semakin tinggi pula prevalensi penyakit-penyakit yang diakibatkan oleh radikal bebas, yang salah satunya disebabkan oleh pola hidup dan polusi yang ada. Untuk menanggulangi radikal bebas tersebut diperlukan antioksidan, yang mana salah satu sumber utamanya adalah dari tanaman herbal. Guna meningkatkan pemanfaatan herbal tersebut, pembuatan sediaan seperti jamu adalah diperlukan karena sediaan ini yang banyak diminati masyarakat. Dalam penelitian ini, herbal seperti bunga rosella, rimpang kunyit, rimpang jahe, sereh, dan jeruk nipis dipilih sebagai bahan jamu godhog yang kaya akan antioksidan. Dalam hal sebagai sediaan jamu, produk ini terbukti cukup aktif dapat menangkap radikal bebas dengan reagen DPPH. Kandungan fenolik dan flavonoid dalam sediaan jamu tersebut adalah komponen utama yang bertanggung jawab terhadap aktivitas penangkapan radikal bebasnya.
Formulasi dan Uji Stabilitas Fisik Sediaan Krim Tabir Surya Pentagamavunon-5 Serta Uji Aktivitasnya Secara In Vitro
Authors: Zulkarnain Abdul Karim , Zulkarnain Abdul Karim , Syach Muhammad Ferdian , Ritmaleni Ritmaleni
Published: October 2024

Pentagamavunon-5 (PGV-5) adalah salah satu senyawa analog kurkumin yang memiliki aktivitas antioksidan yang tinggi yang dapat berpotensi dimanfatkan sebagai bahan aktif tabir surya. Penelitian ini bertujuan untuk mengoptimasikan asam stearat dan parafin cair untuk mendapatkan sediaan tabir surya yang memiliki sifat fisik yang baik serta menghasilkan efek proteksi dari PGV-5 sebagai bahan aktif dengan maksimal. Metode optimasi formula dilakukan dengan mengubah konsentrasi dari asam stearat dan parafin cair. Optimasi dilakukan dengan menggunakan metode Simplex Lattice Design pada Design Expert versi 13 yang dilanjutkan dengan verifikasi formula optimum dan uji sifat fisik serta stabilitas sediaan krim. Data yang diperoleh dilakukan analisis dengan One-Sample t-Test dengan taraf kepercayaan 95% dan IBM SPSS Statistic 26 untuk mengevaluasi stabilitas fisik sediaan. Hasil penelitian menunjukkan bahwa sediaan krim dengan PGV-5 sebesar 0,25% dihasilkan nilai SPF sebesar  40,25; sedangkan SPF basis krim sebesar 6,93. Hasil uji stabilitas fisik sediaan yang disimpan pada suhu ekstrim pada  siklus 0, 1, 2, dan 3 tidak terdapat perbedaan yang signifikan dengan nilai signifikansi > 0.05. Hasil penelitian dapat disimpulkan bahwa sediaan memiliki SPF 40,25 dan stabil selama penyimpanan pada suhu ekstrim. Nilai %Te krim PGV-5 24%, sedangkan nilai %Tp adalah 12,69% termasuk dalam kategori sebagai sunblock
Network Pharmacology Analysis of Secondary Metabolites of Ciplukan (Physalis angulata L.) Against Lung Cancer
Authors: Khoirunnisa Azka , Jamil Ahmad Shobrun , Muchlisin Muhammad Artabah
Published: October 2024

Lung cancer is the most common and high-risk type of cancer. Ciplukan (Physalis angulata L.) has antibacterial, anti-inflammatory, and anticancer activities, as well as cytotoxic ability and inhibits cancer cell growth. Research that discusses the molecular cellular mechanism of P. angulata's potential as an anti-lung cancer has not been widely informed, especially on the network pharmacology aspect of this plant's active compounds. This study reveals the prediction of the molecular mechanism of active compounds of P. angulata as anti-lung cancer using several tools including: Compound database retrieval with Knapsack and PubChem. Absorption Distribution Metabolism and Excretion (ADME) screening with SwissADME. Target protein identification with Gene Card, SwissTargetPrediction and Venny Diagram. Network pharmacology construction with String-DB and Cytoscape. Network pharmacology analysis using Gene Ontology (GO), and Cellular Component and Molecular Function. Based on the results of the analysis of P. angulata protein potential based on Maximal Clique Centrality (MCC) on CytoHubba in Cytoscape application, it shows that the Protein-protein Interaction (PPI) network has 10 main targets, namely ERBB2, KRAS, TP53, PTEN, CDKN2A, NRAS, PIK3CA, BRAF, NF1, and EGFR which interact with each other to regulate cell growth, differentiation, and survival. The results of this study can be concluded that the secondary metabolite compounds of P. angulata have the potential to control and alternative for lung cancer therapy.
Cost Of Illness COVID-19 Inpatient Installation at the UGM Academic Hospital
Authors: Hutahaean Amsaline Vingky , Andayani Tri Murti , Widayanti Anna Wahyuni
Published: October 2024

COVID-19 has become a worldwide pandemic, especially in Indonesia. The high number of COVID-19 cases in Indonesia has a financial impact, as the government must shoulder the cost of dealing with it. The study aimed to determine the direct cost and total cost (cost of illness) of COVID-19 patients at RSA UGM Yogyakarta from a hospital perspective, as well as the differences in total direct cost of hospitalized COVID-19 patients based on age, gender, length of stay, severity, and comorbidity. The cross-sectional study design of the analytic observational research method is based on a hospital perspective. Data was collected retrospectively from the patient's medical record, detailed healthcare expenditure data, and patient claim files. The data was analyzed using univariate, bivariate, and multivariate methods. The study's findings requested the number of inpatient COVID-19 patients as many as 104 samples that satisfied the inclusion specifications, as well as the total direct medical costs of Rp. 2.346.150.137 with an average cost of Rp. 22.559.154 for each patient. The most expensive components were pharmaceutical and BMHP prices of Rp. 958.410.599 (40.85%) and medical support costs of Rp. 725.163.700 (30.91%). Age, length of stay, severity of comorbidities, and usage of antivirals all have an impact on direct medical costs.Keywords: COVID-19, hospital costs, hospital perspective, hospitalization
Analisis Penetapan Prioritas Masalah Distribusi dan Penggunaan Obat di RSUD dr. Soekardjo Tasikmalaya dengan Metode Hanlon
Authors: Aini Nurul , Yuniarti Endang , Satibi Satibi
Published: October 2024

Analisis dengan metode Hanlon digunakan untuk membandingkan masalah kesehatan yang berbeda-beda dalam rangka evaluasi dan bahan pertimbangan dalam menyusun strategi dan pengembangan mutu pelayanan menjadi lebih baik. Penelitian ini bertujuan untuk mengetahui prioritas masalah pada tahap distribusi dan penggunaan obat berdasarkan hasil analisis menggunakan Metode Hanlon di RSUD dr. Soekardjo Tasikmalaya. Rancangan penelitian bersifat deskriptif, pengambilan data secara retrospektif dan concurrent. Data yang dikumpulkan berupa data kuantitatif yang berasal dari penelusuran dokumen tahun 2022 dan pengamatan saat penelitian. Tahap distribusi dan penggunaan obat diukur tingkat efisiensinya menggunakan indikator Depkes (2008) dan penelitian Satibi dkk (2019). Indikator yang belum tercapai diidentifikasi sebagai masalah, kemudian dilakukan pembobotan untuk menetapkan prioritas masalah dengan metode Hanlon. Pada tahap akhir dari penelitian ini adalah perumusan rekomendasi strategi perbaikan berdasarkan prioritas masalah yang ditemukan. Hasil evaluasi pengelolaan obat pada tahap distribusi dan penggunaan obat dari 9 indikator yang diteliti terdapat 7 indikator yang belum sesuai standar. Penetapan prioritas masalah menggunakan metode Hanlon mendapatkan hasil indikator rata-rata waktu tunggu dan tingkat ketersediaan obat merupakan prioritas utama untuk diselesaikan. Rekomendasi strategi perbaikannya yaitu peresepan elektronik, menggunakan alat bantu Artificial Intelligence, pelatihan staf secara berkala, pengendalian dengan metode MMSL, implementasi forecasting kebutuhan obat dan pembayaran ke distributor tepat waktu.
Narative Review: Kejadian Dan Mekanisme Kardiotoksisitas Pada Pasien Kanker Payudara Setelah Penggunaan Trastuzumab
Authors: Sari Laras Ratna , Murwanti Retno , Rahmawati Fita
Published: October 2024

Kardiotoksisitas adalah terjadinya disfungsi jantung sebagai kerusakan listrik atau otot, yang mengakibatkan jantung menjadi lebih lemah dan tidak efisien dalam memompa darah. Kardiotoksisitas dapat disebabkan oleh beberapa hal seperti agen kemoterapi, pengobatan radioterapi, komplikasi dari anoreksia nervosa, efek samping dari asupan logam berat. Kardiotoksisitas juga terjadi pada pasien kanker payudara yang diberikan terapi trastuzumab. Tujuan dari tinjauan artikel ini yaitu untuk mengetahui kejadian kardiotoksisitas setelah penggunaan trastuzumab dan mekanisme efek kardiotoksisitas trastuzumab pada pasien kanker payudara. Metode yang digunakan pada artikel ini yaitu menggunakan beberapa pencarian menggunakan PubMed, ScienceDirect dan Google Cendekia untuk penelitian yang membahas efek kardiotoksisitas trastuzumab pada pasien kanker payudara dari tahun 2018 sampai dengan 2023. Dari total 171 artikel, yang kemudian dievaluasi berdasarkan kriteria inklusi dan eksklusi. Sebanyak 157 artikel dikeluarkan dan 14 artikel yang memenuhi kriteria inklusi. Mekanisme terjadinya kardiotoksisitas oleh trastuzumab melalui mekanime penghambatan HER2 dan autophagy. Kesimpulannya, Pemilihan trastuzumab sebagai pilihan terapi pada pasien kanker payudara harus dipertimbangkan dengan cermat dan diperlukan pemantauan fungsi jantung.
A Preliminary Adaptation and Validation of the Indonesian Version of the Loneliness and Aloneness Scale for Children and Adolescent (LACA)
Authors: Gultom Lydia Agnes , Triwahyuni Airin , Qodariah Laila
Published: October 2024

Measuring loneliness in children and adolescents is crucial, as it is a prevalent issue that can impact their emotional and social development. Despite its importance, there are limited validated tools available to assess loneliness within the Indonesian cultural context. The Loneliness and Aloneness Scale for Children and Adolescents (LACA) is a widely used instrument for assessing feelings of loneliness and aloneness among children and adolescents. This study aimed to adapt and collect evidence of the validity of the Indonesian version of the LACA following the International Test Commission (ITC) Guidelines for Translating and Adapting Tests. Using the convenience sampling technique, 297 children and adolescents aged 10–18 years were selected as respondents in this study. The results show that the Indonesian version of four LACA sub-scales has good internal consistency. Confirmatory factor analysis shows that the four-factor model has an acceptable model fit. However, six items were omitted from the LACA loneliness measurement model for having a low contribution to loneliness. As a result, the four-factor model with fewer items shows a better fit. According to the research findings, the Indonesian version of the LACA can be used to measure loneliness and attitudes toward aloneness in the population of children and adolescents in Indonesia, with a recommendation to omit six items. The results of the tests on alternative two-factor models show that the loneliness in relationships with parents and loneliness in relationships with peers sub-scales can be used separately to measure the source of loneliness in children and adolescents in Indonesia.
The Research on Teaching Reform of Civil Engineering Construction Course Based on Rich Practical Teaching
Authors: Yang Liu , Jing Gao , Ming-zhi Song , Zhe Kong
Published: October 2024

As a comprehensive, practical, and timely course, the Civil Engineering Construction course requires university teachers to possess systematic theoretical knowledge and practical engineering experience. Therefore, universities need to establish a “dual-qualified” teaching team through industry-academic collaboration. This paper focuses on the Civil Engineering Construction course at Qingdao City College, collaborating with Zhongqing Jian’an Construction Group Co., Ltd., to discuss the model of school-enterprise cooperation and the understanding of curriculum reform oriented towards practical teaching. This paper highlights the significant contribution of strong collaboration between schools and enterprises in practical teaching to improving the quality of talent cultivation in the civil engineering profession. Based on the educational research projects at Qingdao City College, it primarily investigates the expansion of school-enterprise cooperation forms, the development of industry-academic-research project collaborations, the exploration of new models for curriculum design guidance, the construction of a reasonable and comprehensive teaching system for green construction courses, and the innovation of teaching methods.
The Impact of the Usage of Cryptocurrency on Perceived Benefits and Users’ Behavior
Authors: Nujoma Kandorera Angela
Published: October 2024

The purpose of this essay is to examine how consumers' behavior and perceived advantages are affected when they utilize cryptocurrencies. The basis for this study has been the Technology Acceptance Model. Three primary factors—reported ease of use, perceived advantages, and use behavior—were investigated in this research. Surveys are used in a quantitative way to gauge the influence of these elements. A total of 186 experts in the field of cryptocurrencies took part in the online questionnaire. Based on the structural equation model, it can be known that perceived ease of use presents a significant positive influence on perceived benefits, and perceived benefits also have a significant positive influence on user behaviour, and perceived ease of use does not have a significant influence on user behaviour, but with the extension of the use time, the user's perception of ease of use of cryptocurrencies is enhanced. Through logistic regression, it can be learned that perceived benefits and user behaviour have a significant positive impact on cryptocurrency. That is, the greater the perceived benefits of using cryptocurrencies, the greater the likelihood that users will use cryptocurrencies, and the greater the amount of usage is likely to be. Similarly, users' actual behaviour towards cryptocurrencies significantly contributes to the development and use of cryptocurrencies. Based on the above empirical results, this paper provides certain suggestions and outlooks for the future development of cryptocurrencies.
Research on the Quality of Teacher-Child Interaction under the Collective Teaching Activities of Social Education for Large Class Children
Authors: Dong Ruiqing , Yin Shengnan
Published: October 2024

This study of the current situation of the interaction, from the kindergarten collective teaching activities, interaction and social field concept from three aspects, analyze its characteristics, observe the garden of interaction, writing interview outline, through observation and action research method, the social field of the status of the interaction analysis and its problems. The research tool for this study was the Flanders Interactive Analysis System, by which 18 activities were analyzed. Finally, according to the interview content, the characteristics and influencing factors of teacher and child interaction were summarized, and the strategies and methods of improving the quality of teacher and child interaction were analyzed.
Exploration of the Computational Predicted Internal Tagging Preferred Protein Properties
Authors: Chen Ruoyu , Gerasimavicius Lukas
Published: October 2024

Protein tags are commonly used in many biological experiments, and adding a tag to an intolerant sequence position can significantly damage the functions of a protein and affect the outcome of an experiment. Recently, an in-house computational prediction method, TagScore, was developed which uses sequence homology to identify non-conservative regions of proteins permissive of tagging. The properties of the proteins that are predicted by TagScore to prefer internal tagging were explored using gene enrichment strategies. Proteins that prefer internal tagging were found to be related to GTPase-associated proteins and sequence features with disordered and polar regions, as predicted by TagScore.
Challenging Patriarchal Representations: Women's Metafictional Writing
Authors: Guzikowska Julia
Published: October 2024

In line with Friedman and Fuchs’s understanding of women’s experimental writing,  I argue that through the means of metafiction, which subverts the established notions of realism and stresses the constructedness of reality, authors like Acker and Sapphire create room and possibility for women’s radical opposition against established norms of literary patriarchal structures as well as voice a call for their liberation. These works are rooted in the ideas of agency; through the experimental and metafictional form, they assert the writer’s freedom and thus give power to the marginalised feminine.
Considerations of Intersectionality in Psychological research
Authors: Nicoll Abigail
Published: October 2024

At the forefront of the increasingly popular intersectionality agenda in psychology is the wellbeing of individuals. The British Psychological Society states that a key principle of psychological research is to “consider societal benefits” and “contribute to the common good” (BPS, 2021). There is an abundance of evidence on the harmful outcomes of negative intergroup relations and systemic oppression on marginalised individuals. For example, marginalised groups often experience educational and economic disadvantages (Porter, 2011) alongside both physical and mental health disparities (English et al., 2022; Mitchell et al., 2021; Stevens-Watkins et al., 2014). Consequently, psychology as a discipline should prioritise advocating for a more equitable society.
Mastrick
Authors: Mutch Alistair
Published: October 2024

Material culture, Farming history, Archaeology, Archives, Aberdeenshire, Aberdeen Doctors, Episcopalianism, religious history,  Alexander Stewart, Mastrick, Scottish culture, Ethnology, Folklore, Folk life, Rural life, Local Studies, Regional Studies
Stills, Shielings and Retting Ponds
Authors: Dixon Piers , Durham Joyce
Published: October 2024

Folklore, Ethnology, Scottish History, Rural life, Regional Studies, Local Studies, Archaeology, Material Culture, Scottish Borders, Cultural History, Fieldwork, Excavation, Stills, Illicit Stills, Distilling, Shielings, Retting ponds, Farming History
A Smart and Sustainable Framework to Combat Climate Change: A Comprehensive Approach of Artificial Intelligence and Human Psychology
Authors: Maheshwari Prerna
Published: October 2024

The core of this paper, which explores the difficulties of resource problems and climate change, is the delicate interplay between AI, human psychology, and sustainable development. As global challenges escalate, the convergence of these domains presents a unique opportunity to devise effective strategies that facilitate environmentally conscious behaviors and resilient communities. This paper explores the psychological dimensions underlying resource dilemmas and climate change, emphasizing cognition, decision-making processes, social dynamics, and the role of AI in driving sustainable development. By amalgamating insights from psychology with cutting-edge technological advancements, society can aspire to navigate the path towards ecological equilibrium and a sustainable future
Brief Overview on Pathology of Blood and Urine
Authors: Pawar Mr. Abhishek D.
Published: October 2024

Clinical pathology is recognized as an essential component of the preclinical safety evaluation of test articles (new chemical entities, exploratory novel medicines, and xenobiotics), particularly in short- and medium-term toxicity studies. Traditionally, this evaluation includes clinical chemistry, coagulation, hematology, and urinalysis assessments. The findings of these assessments include details on the general state of health of the animals as well as target organs and general metabolic, adaptive, or harmful processes linked to test material exposure. Consequently, in the preclinical safety assessment of a test article, clinical pathology evaluations aid in the establishment of toxicological dose-response correlations. These findings hold significance and relevance for dose selection in long-term research, as well as for risk assessment and management when applied to humans. Guidance on the fundamentals of clinical pathology testing and interpretation in the species utilized in toxicological investigations is the aim of this chapter. In order to increase testing capacity and enhance its ability to identify more sensitive, early signals of drug-induced target organ toxicity or pathophysiology, the application of clinical pathology testing in preclinical safety assessment as well as the areas of development for novel biomarker implementation within the laboratory are discussed. Lastly, the significance of interpreting clinical pathology and combining the results with data from other studies is emphasized when assessing overall safety or risk assessment
Static and Thermal Analysis of Internal Combustion Engine Valves
Authors: Mereuta Valentin
Published: October 2024

Abstract: In this paper the 3D model of the internal combustion engine valves was realized using Autodesk Inventor Professional 2024 and finite element analysis, static and thermal was performed, in order to determine the state of stress, deformation and temperature evolution, by applying restrictions and loads conditions. Two materials were chosen, for internal combustion engine valves, in accordance with the specialized literature. The materials taken for static and thermal analysis was Stainless Steel AISI 446 and NiCr0TiAl. Following the comparative study for the two models, it can be specified the importance of the material for the construction of the internal combustion engine valves who depends on the material properties and their design.
Method for determining the plan view coordinates and height of the working benchmark on a landslide with forced inclinations of the pole from the plumb position
Authors: Kuzin A.A. , Filippov V.G.
Published: October 2024

Determination of plan view coordinates and working benchmarks heights on a landslide by linear-angular measurements using electronic total stations by the polar notching method and trigonometric levelling involves installing a prism reflector on a tripod or a pole plumb above the observed benchmark. In order to put it in the mentioned position, round levels are used, its accuracy affects precise determining the plan view coordinates and the benchmark heights. Direct visibility from the reference benchmark to the working one may be lost due to landslide displacements, reappeared vegetation or other obstacles. These circumstances may cause incomplete or distorted interpretation of the landslide hazard forecast during cyclic multi-year observations. The authors propose a new method of determining the plan view coordinates and height of the working benchmark on a landslide by linear-angular measurements on a pole with a prism reflector with its forced inclinations from the plumb position. The required data is calculated as the said parameters of the sphere center, which is constructed by approximation of those of the prism reflector node point obtained by tilting the pole. A number of experiments were carried out to confirm the performance of the method in geodetic landslide observations and its suitability for use in cases of visibility loss to the benchmark at the plumb position of the pole
Mapping caves due to photogrammetric data
Authors: Shcherbakov V.M. , Skrypitsyna T.N. , Ukolova A.V.
Published: October 2024

The authors present a new approach to mapping hard-to-reach caves. It relies on a modern framework of ground-based stereo photogrammetric and geodetic surveying, aerial photography from UAVs and computer modelling. A stereo system was designed and assembled, consisting of two GoProHero9 Black cameras and a powerful artificial light source with diffusing lens, mounted on the operator`s helmet. The site for underground filming was the Syanovskaya quarry (Moscow oblast, Domodedovo rayon). The aerial survey of the cave ground part was also made with DJIAir 2S UAV; it included a ravine with a concrete well, which was the entrance to the quarry. The article deals with the processes of geodetic georeferencing, external orientation of the surface model and underground parts of the cave, as well as the cartographic materials obtained in the course of the work
AVALIAÇÃO DA QUALIDADE DE FARINHAS DE MARACUJÁ: UM ESTUDO DE CASO
Authors: Marques Carlos Alexandre , Torres José Celso , Nazareth Pinho de Aguiar Kelly Lúcia , Alves Brayner Pereira Kaio
Published: October 2024

Apresentam-se testes químicos e análise microscópica de amostras de farinhas de maracujá comercializadas como suplementos alimentares. Todas as amostras comerciais apresentaram sujidades, mas somente um dos materiais excedeu o quantitativo tolerado na RDC no 623 de 9 de março de 2022 da ANVISA, indicando falhas de boas práticas. Os resultados obtidos permitiram concluir que testes e análises simples e de baixo custo podem contribuir, com precisão, para avaliação da qualidade desses produtos cada vez mais consumidos como suplementos alimentares.
Avaliação do impacto de um programa de apoio à transição para vida adulta em Portugal
Authors: Canha Lúcia , Souza Leonardo Santos de , Murgo Camélia Santina
Published: October 2024

As pessoas com deficiência enfrentam dificuldades significativas na transição para a vida adulta, incluindo obstáculos na educação, empregabilidade, vida independente, desenvolvimento social e acesso a suporte contínuo. Este artigo estuda os benefícios de um programa de apoio a pessoas com deficiência em Portugal, o Programa Sintra Inclui+, com foco na inclusão laboral e comunitária. Foram realizados grupos focais compostos por 13 pessoas com deficiência, as quais receberam apoio do programa, junto a 6 representantes das entidades empregadoras que os acolheram. Os resultados destacam a importância do suporte na promoção do desenvolvimento pessoal, social e profissional dessas pessoas. Os jovens reconheceram não só sua capacidade de aprender funções laborais, mas também de desenvolvimento pessoal e social. Os empregadores destacaram a sua capacidade de aprender e de se adaptar, o que mudou as percepções e expectativas sobre os trabalhadores com deficiência. Esse apoio demonstrou ser essencial para criar perspectivas de futuro mais promissoras, além de reforçar a motivação e a persistência necessárias para a construção de uma carreira profissional e uma vida ativa na comunidade. O estudo sugere que programas dessa natureza são eficazes na promoção da inclusão e autodeterminação das pessoas com deficiência, por isso devem atuar desde cedo na escola e continuar logo após a escolaridade obrigatória. Os resultados são discutidos e são fornecidas as implicações para a prática e a pesquisa.
Formar professores para a inclusão escolar
Authors: Mantoan Maria Teresa Eglér , Lanuti José Eduardo de Oliveira Evangelista , Baptista Maria Isabel Sampaio Dias
Published: October 2024

Este texto apresenta e analisa como o Laboratório de Estudos e Pesquisas em Ensino e Diferença (LEPED) da Faculdade de Educação (FE) da Universidade Estadual de Campinas (UNICAMP) tem proposto a formação continuada de milhares de professores (e demais interessados) para: esclarecer o direito à educação; demonstrar como a inclusão escolar se realiza nas salas de aula (planejamento, avaliação e outros aspectos relacionados ao ensino e à aprendizagem escolar). O artigo explicita o modo como esses cursos foram idealizados e produzidos como Cursos de Difusão Cultural desde 2018, utilizando a plataforma de Educação a Distância (EaD) da Escola de Extensão da UNICAMP (EXTECAMP). O modo de apresentação dos conteúdos dos cursos; os recursos de acessibilidade presentes em todos os seus módulos e a autoavaliação dos participantes são destacados neste artigo. Todos os cursos se apoiam na ideia de emancipação intelectual dos cursistas para sua realização.
Editorial: Corporate governance — Aspects of sustainability, risk management, and firm performance
Authors: Agnihotri Anurag
Published: October 2024

The current issue brings forth a collection of four insightful papers that delve into diverse aspects of sustainability, risk management, and firm performance. Each paper explores critical areas of research, offering a blend of theoretical and practical insights with a focus on future research directions. Below is a detailed editorial review of the issue.
Metodología relacional en investigación cualitativa: más allá del análisis
Authors: Bedoya Olga Lucia
Published: October 2024

El tema central de este texto es la metodología relacional en investigación cualitativa: más allá del análisis, este surge a partir de una vivencia personal que recoge más de 20 años de experiencia profesional –desde 1995– de dirección de aproximadamente 150 tesistas, entre estudiantes de maestría1 y doctorado2 . Producto de esa experiencia, se detecta que el mayor obstáculo a la hora de realizar una lectura holística del dato es el hecho de solo abordar el proceso desde el análisis (separación) y no avanzar a la integración de éste. Después de una ardua labor de recolección de datos (a través de técnicas como la encuesta, la entrevista, la observación, las pruebas, diarios de campo, entre otros), el estudiante no se sabe qué hacer con todo lo que ha recolectado y se queda estacionado en un primer nivel de análisis. Así, los que usan las estadísticas, leen las tendencias, dejando por fuera los residuos (los desechan), la relación tendencia/residuo, y los que utilizan el análisis textual, presentan tablas descriptivas; no obstante, ninguna de las dos formas de abordar el material recopilado muestra las relaciones ni la integración entre los datos. Por ejemplo, la relación entre la tendencia y la no tendencia, que se puede inferir, o la comparación entre los tres valores de la campana de Gauss: el centro, el extremo izquierdo y el extremo derecho. Incluso, algunos estudiantes llegan a construir grandes bases de datos que admiten el manejo de dos o tres variables para analizar datos (v. gr. Excel), pero las relaciones son siempre simples, por la ausencia de comprender el sentido total de la información. Ahora, con respecto del tratamiento del software cualitativo (v. gr. Atlas Ti. y Nvivo), he notado que no hay comprensión sobre todo el potencial interpretativo que ofrecen las herramientas. Por lo tanto, el estudiante se queda en la primera parte de codificación libre, y presentan el informe desde allí. El escenario descrito es al que llamo primer nivel, desintegrar el dato. La propuesta parte desde el convencimiento de que, si no hay una mayor comprensión del proceso holístico de los datos, no se pueden alcanzar mayores niveles interpretativos y, por ende, los resultados de la investigación serán más pobres.
La responsabilidad civil de los abogados en el derecho romano, en el Código Civil y el Código Civil y Comercial de la Nación
Authors: Casen Rosa Luz
Published: October 2024

Tema central en el ejercicio profesional es la responsabilidad civil del abogado para lo cual hemos partido de los antecedentes de esta profesión en las diferentes épocas de Roma. También se verán las normas aplicables a la responsabilidad civil de las profesiones en el romanista Código Civil de Vélez. Por último, las novedades del Código Civil y Comercial de la Nación (CCCN), en lo concerniente a la responsabilidad civil, y en particular, a la responsabilidad de las profesiones liberales serán la última escala.
Nerón y el incendio de Roma desde la visión de un autor polaco del siglo XIX
Authors: Gallo Rosana
Published: October 2024

En este trabajo de investigación se analizará la visión que el polaco Józef Ignacy Kraszewski le dio en su novela Roma bajo Nerón al imperio romano al mando de éste. A medida que nos introducimos en esta obra de arte literaria advertiremos cómo la Roma imperial impactó a la imaginación de los polacos del siglo XIX, a tal punto de concebir su autor, en su fructuosa imaginación, este maravilloso texto, hoy un poco olvidado en el mundo de las letras pero no por eso menos valioso y romántico.  Para ello veremos la vida del emperador y su contexto histórico, la vida y obra del autor polaco dentro del contexto histórico en que vivió seguido del análisis de la obra objeto de estudio. El objetivo de la presente investigación será reivindicar las letras polacas al servicio del arte universal, tomando como inspiración la cuna de la civilización romana.
Estimation of Water Velocity and Receiver Position Changes in Time-Lapse Seismic Using Machine Learning
Authors: Araujo Ramon C. F. , Corso Gilberto , Nascimento Hugo A. D. , Souza Samuel Xavier , Araujo João M. , Barros Tiago
Published: October 2024

Non-repeatability is one of the main obstacles in time-lapse seismic, as it significantly degrades the interpretation of reservoir-related signals. Correcting the data variations caused by non-repeatability (4D noise) is of paramount importance, which usually requires the estimation of the changing parameter. ln this paper, we propose a Machine Learning (ML) workflow for the quantitative estimation of two types of 4D noise: changes in the speed of sound in water and receiver lateral positions. A synthetic database, modeled from a velocity model estimated from the Brazilian pre-salt, and containing many time-lapse seismic surveys was generated for the supervised training of ML models. lnput samples consist of subsets of common-shot seismograms. We studied many combinations of ML regression algorithms and feature extraction techniques, for scenarios where data is contaminated, or not, with Gaussian random noise. The regression algorithms considered were Fully-Connected Neural Network, Extreme Gradient Boosting, and Bayesian Ridge. Four rectangular crops of the common-shot seismogram were tested as input features: full seismogram, first half of time samples, 11 smallest-offset traces, and the time samples focusing on the first arrivals region. The combination with the best trade-off between accuracy and model complexity is the Bayesian Ridge fed with the 11 smallest-offset traces, which estimated position and velocity time-lapse changes with median accuracy of 0.115 m and 0.017 m/s for the case with Gaussian noise. Besides the correction of repeatability-related variations, our results are useful in the 4D Full-Waveform lnversion which needs accurate parameters to produce good seismic images.
Petrophysical Evaluation of Arkoses Reservoirs Based on Well Logs and Plug Samples: A Case Study From Alagamar Formation, Southeastern Portion of Onshore Potiguar Basin, Brazil
Authors: Ferreira Victor , Freire Antonio Fernando Menezes , Lupinacci Wagner Moreira
Published: October 2024

The Potiguar Basin is a sedimentary basin located in northeastern Brazil. It covers about 48,000 km² and extends from onshore to offshore. The onshore basin is thought to have formed during the Late Cretaceous, as a result of the opening of the Equatorial South Atlantic Ocean, filled with a thick sequence of sedimentary rocks, including sandstones, shales, and limestones, which were deposited in a variety of processes, including marine, deltaic, and fluvial. The study area is in the southern portion of the basin and the reservoir is composed of arkose sandstones deposited by alluvial fan and fluvial systems of the Upanema Member of the Alagamar Formation, which belongs to the post-rift phase of the Potiguar Basin. Recently, new drilling campaigns revealed a reservoir heterogeneity in these deposits, which requested a new petrophysical approach. Using conventional well logs and petrophysical laboratory analysis of plug samples, this study evaluated the best way to calculate the effective porosity, and shale volume and to understand the stratigraphic controls in the distribution of these properties. Three reservoir zones were mapped: the basal one, Zone 3, has disconnected sand bodies, low porosity, and high shale content; Zone 2 has better petrophysical properties, lateral distribution, and connectivity between the fans and Zone 1 is the better reservoir zone with larger sand bodies, higher porosity values, and well-connected fans.