bluuebunny/crossref_metadata_2025 huggingface dataset:
Radiation Dose and Fluoroscopy Time of Diagnostic Angiography in Patients with Spinal Dural Arteriovenous Fistula
Authors: Ozpeynirci Yigit , Trumm Christoph , Stahl Robert , Fischer David , Liebig Thomas , Forbrig Robert
Published: January 2022

Purpose

Spinal dural arteriovenous fistulas (SDAVFs) represent the most common indication for a spinal angiography. The diagnostic reference level (DRL) for this specific endovascular procedure is still to be determined. This single-center study provides detailed dosimetrics of diagnostic spinal angiography performed in patients with SDAVFs.

Methods

Retrospective analysis of all diagnostic spinal angiographies between December 2011 and January 2021. Only patients with an SDAVF who had baseline magnetic resonance angiography (MRA), diagnostic digital subtraction angiography (DSA), treatment and follow-up at this institution were included. Dose area product (DAP, Gy cm2) and fluoroscopy time were compared between preoperative and postoperative angiographies, according to SDAVF locations (common versus uncommon), MRA results at baseline (positive versus negative) and DSA protocols (low-dose, mixed-dose, normal-dose). The 75th percentile of the DAP distribution was used to define the local DRL.

Results

A total of 62 spinal angiographies were performed in 25 patients with SDAVF. Preoperative angiographies (30/62, 48%) yielded a significantly higher DAP and longer fluoroscopy time when compared to postoperative angiographies (32/62, 53%) (p < 0.01). The local DRL was 329.41 Gy cm2 for a nonspecific (n = 62), 395.59 Gy cm2 for a preoperative and 138.6 Gy cm2 for a postoperative spinal angiography. Preoperative angiography of uncommonly located SDAVFs yielded a significantly longer fluoroscopy time (p = 0.02). The MRA-based fistula detection had no significant impact on dosimetrics (p > 0.05). A low-dose protocol yielded a 61% reduction of DAP.

Conclusion

The results of the present study suggest novel DRLs for spinal angiography in patients with SDAVF. Dedicated low-dose protocols enable radiation dose optimization in these procedures.
Feeding Brassica vegetables to rats leads to the formation of characteristic DNA adducts (from 1-methoxy-3-indolylmethyl glucosinolate) in many tissues
Authors: Glatt Hansruedi , Engst Wolfram , Florian Simone , Schreiner Monika , Baasanjav-Gerber Chimgee
Published: January 2022

Juices of Brassica vegetables are mutagenic and form characteristic DNA adducts in bacteria and mammalian cells. In this study, we examined whether such adducts are also formed in vivo in animal models. Rats fed raw broccoli ad libitum in addition to normal laboratory chow for 5 weeks showed one major adduct spot and sometimes an additional minor adduct spot in liver, kidney, lung, blood and the gastrointestinal tract, as determined by 32P-postlabelling/thin-layer chromatography. Adducts with the same chromatographic properties were formed when herring sperm DNA (or dG-3’-phosphate) was incubated with 1-methoxy-3-indolylmethyl glucosinolate (phytochemical present in Brassica plants), in the presence of myrosinase (plant enzyme that hydrolyses glucosinolates to bioactive breakdown products). UPLC–MS/MS analysis corroborated this finding: 1-Methoxy-3-indolylmethyl-substituted purine nucleosides were detected in the hepatic DNA of broccoli-fed animals, but not in control animals. Feeding raw cauliflower led to the formation of the same adducts. When steamed rather than raw broccoli was used, the adduct levels were essentially unchanged in liver and jejunum, but elevated in large intestine. Due to inactivation of myrosinase by the steaming, higher levels of the glucosinolates may have reached the large bowl to be activated by glucosidases from intestinal bacteria. In conclusion, the consumption of common Brassica vegetables can lead to the formation of substantial levels of DNA adducts in animal models. The adducts can be attributed to a specific phytochemical, neoglucobrassicin (1-methoxy-3-indolylmethyl glucosinolate).
Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation
Authors: van den Berg Boudewijn , Hijma Hemme J. , Koopmans Ingrid , Doll Robert J. , Zuiker Rob G. J. A. , Groeneveld Geert Jan , Buitenweg Jan R.
Published: January 2022

Sleep deprivation has been shown to increase pain intensity and decrease pain thresholds in healthy subjects. In chronic pain patients, sleep impairment often worsens the perceived pain intensity. This increased pain perception is the result of altered nociceptive processing. We recently developed a method to quantify and monitor altered nociceptive processing by simultaneous tracking of psychophysical detection thresholds and recording of evoked cortical potentials during intra-epidermal electric stimulation. In this study, we assessed the sensitivity of nociceptive detection thresholds and evoked potentials to altered nociceptive processing after sleep deprivation in an exploratory study with 24 healthy male and 24 healthy female subjects. In each subject, we tracked nociceptive detection thresholds and recorded central evoked potentials in response to 180 single- and 180 double-pulse intra-epidermal electric stimuli. Results showed that the detection thresholds for single- and double-pulse stimuli and the average central evoked potential for single-pulse stimuli were significantly decreased after sleep deprivation. When analyzed separated by sex, these effects were only significant in the male population. Multivariate analysis showed that the decrease of central evoked potential was associated with a decrease of task-related evoked activity. Measurement repetition led to a decrease of the detection threshold to double-pulse stimuli in the mixed and the female population, but did not significantly affect any other outcome measures. These results suggest that simultaneous tracking of psychophysical detection thresholds and evoked potentials is a useful method to observe altered nociceptive processing after sleep deprivation, but is also sensitive to sex differences and measurement repetition.
Analgesia in the Initial Management of Acute Pancreatitis: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials
Authors: Thavanesan Navamayooran , White Sophie , Lee Shiela , Ratnayake Bathiya , Oppong Kofi W. , Nayar Manu K. , Sharp Linda , Drewes Asbjørn Mohr , Capurso Gabriele , De‐Madaria Enrique , Siriwardena Ajith K. , Windsor John A. , Pandanaboyana Sanjay
Published: January 2022

Background

The optimal analgesic strategy for patients with acute pancreatitis (AP) remains unknown.

Objective

The present systematic review and meta‐analysis aims to compare the efficacy of different analgesic modalities trialled in AP.

Methods

A systematic search of PubMed, MEDLINE, EMBASE, CENTRAL, SCOPUS and Web of Science conducted up until June 2021, identified all randomised control trials (RCTs) comparing analgesic modalities in AP. A pooled analysis was undertaken of the improvement in pain scores as reported on visual analogue scale (VAS) on day 0, day 1 and day 2.

Results

Twelve RCTs were identified including 542 patients. Seven trial drugs were compared: opiates, non‐steroidal anti‐inflammatories (NSAIDs), metamizole, local anaesthetic, epidural, paracetamol, and placebo. Across all modalities, the pooled VAS scores showed global improvement from baseline to day 2. Epidural analgesia appears to provide the greatest improvement in VAS within the first 24 h but is equivalent to opiates by 48 h. Within 24 h, NSAIDs offered similar pain‐relief to opiates, while placebo also showed equivalence to other modalities but then plateaued. Local anaesthetics demonstrated least overall efficacy. VAS scores for opiate and non‐opiate analgesics were comparable at baseline and day 1. The identified RCTs demonstrated significant statistical and methodological heterogeneity in pain‐relief reporting.

Conclusions

There is remarkable paucity of level 1 evidence to guide pain management in AP with small datasets per study. Epidural administration appears effective within the first 24 h of AP although infrequently used and featured in only a single RCT. NSAIDs are an effective opiate sparing alternative during the first 24 h.
Peritoneal carcinosis in male germ cell tumor patients: a registry study compiled by the German Testicular Cancer Study Group (GTCSG)
Authors: Seidel Christoph , Hentrich Marcus , Zschäbitz Stefanie , Paffenholz Pia , Heidenreich Axel , Nestler Tim , Tran Ben , Fischer Stefanie , Daugaard Gedske , Ochsenreither Sebastian , Brito Margarida , Zengerling Friedemann , Schwab Constantin , Bokemeyer Carsten , Oing Christoph
Published: January 2022

Purpose

To report on the clinical characteristics, outcome, and frequency of peritoneal carcinosis (PC) in patients with advanced germ cell tumors (GCT), a multicenter registry analysis was carried out.

Methods

A multicenter registry analysis was conducted by the German Testicular Cancer Study Group (GTCSG) with international collaborators. Data was collected and analyzed retrospectively. Patients were eligible for inclusion if PC was diagnosed either by radiologic or histopathologic finding during the course of disease. Descriptive and explorative statistical analysis was carried out with cancer-specific survival (CSS) as primary study endpoint.

Results

Collaborators from ten GCT expert centers identified 28 GCT (0.77%) patients with PC after screening approximately 3767 GCT patient files and one case was contributed from a cancer registry request. Patients were diagnosed from 1997 to 2019 at a median age of 37 years (interquartile range, 13). Two patients (7%) presented with stage I and 27 patients (93%) with synchronous metastatic disease at first diagnosis. The primary histology was seminoma in seven (27%) and non-seminoma in 21 patients (72%). PC was detected after a median of 15.3 months from primary diagnosis (range 0–177) and two consecutive treatment lines (range 0–5), respectively. The median CSS from the time of detection of PC was 10.5 months (95%Confidence Interval 0.47–1.30) associated with an overall 2-year CSS rate of 30%.

Conclusion

PC represents a rare tumor manifestation in GCT patients and was primarily associated with the occurrence of advanced cisplatin-refractory disease conferring to a dismal prognosis.
The importance of time of day for magnetic body alignment in songbirds
Authors: Bianco Giuseppe , Köhler Robin Clemens , Ilieva Mihaela , Åkesson Susanne
Published: January 2022

Spontaneous magnetic alignment is the simplest known directional response to the geomagnetic field that animals perform. Magnetic alignment is not a goal directed response and its relevance in the context of orientation and navigation has received little attention. Migratory songbirds, long-standing model organisms for studying magnetosensation, have recently been reported to align their body with the geomagnetic field. To explore whether the magnetic alignment behaviour in songbirds is involved in the underlying mechanism for compass calibration, which have been suggested to occur near to sunset, we studied juvenile Eurasian reed warblers (Acrocephalus scirpaceus) captured at stopover during their first autumn migration. We kept one group of birds in local daylight conditions and an experimental group under a 2 h delayed sunset. We used an ad hoc machine learning algorithm to track the birds’ body alignment over a 2-week period. Our results show that magnetic body alignment occurs prior to sunset, but shifts to a more northeast–southwest alignment afterwards. Our findings support the hypothesis that body alignment could be associated with how directional celestial and magnetic cues are integrated in the compass of migratory birds.
Effects of cardiac surgical support on long-term outcomes of emergent or complex percutaneous coronary intervention cases: a sub-analysis of the SHINANO 5-year registry
Authors: Nakamura Chie , Ebisawa Soichiro , Miura Takashi , Nomi Hidetomo , Kanzaki Yusuke , Yui Hisanori , Maruyama Shusaku , Nagae Ayumu , Ueki Yasushi , Sakai Takahiro , Kato Tamon , Saigusa Tatsuya , Okada Ayako , Motoki Hirohiko , Kuwahara Koichiro
Published: January 2022

Significant improvements in percutaneous coronary intervention (PCI) technology have enabled cardiovascular procedures to be performed without onsite cardiac surgery facilities. However, little is known about the association between onsite cardiac surgical support and long-term outcomes of PCI, particularly among emergent and complex cases. We investigated whether the presence or absence of cardiovascular surgery affects the long-term prognosis after PCI, emergent and complex elective cases. The SHINANO 5-year registry, a prospective, observational, and multicenter cohort study registry in Nagano, Japan, consecutively included 1665 patients who underwent PCI between August 2012 and July 2013. The procedures were performed at 11 hospitals with onsite cardiac surgery facilities [onsite surgery (+) group; n = 1257] and 8 hospitals without onsite cardiac surgery facilities [onsite surgery (−) group; n = 408]. The primary endpoint was all-cause mortality and the secondary endpoint was major adverse cardiac and cerebrovascular events [MACCE: all-cause death, Q-wave myocardial infarction, non-fatal stroke, and target lesion revascularization]. The onsite surgery group (+) had a lower rate of emergent PCI and ST-segment elevation myocardial infarction (40.8% vs. 51.7%, p < 0.01 and 24.9% vs. 39.2%, p < 0.01, respectively), and a higher prevalence of hemodialysis and history of peripheral artery disease (7.6% vs. 2.45%, p < 0.01 and 12.1% vs. 6.9%, p < 0.01, respectively). However, the Kaplan–Meier analysis showed no difference in the 5-year mortality rate (16.4% vs. 15.2%, p = 0.421) and MACCE incidence (31.6% vs. 28.9%, p = 0.354) between the groups. Also, there were no differences in the mortality rate and incidence of MACCE among emergent cases of ST-segment elevation myocardial infarction and complex elective cases who underwent PCI. Long-term outcomes of PCI appear to be comparable between institutions with and without onsite cardiac surgical facilities.
Mesenteric occlusive disease of the inferior mesenteric artery is associated with anastomotic leak after left-sided colon and rectal cancer surgery: a retrospective cohort study
Authors: Arron Melissa N. N. , Broek Richard P. G. ten , Adriaansens Carleen M. E. M. , Bluiminck Stijn , van Wely Bob J. , Ferenschild Floris T. J. , Smits Henk F. M. , van Goor Harry , de Wilt Johannes H. W. , van Petersen André S.
Published: January 2022

Purpose

Anastomotic leak (AL) is a serious complication following colorectal surgery. Atherosclerosis causes inadequate anastomotic perfusion and is suggested to be a risk factor for AL. The aim of this study was to investigate the association of mesenteric occlusive disease on preoperative computed tomography (CT) scan with AL after left-sided colon or rectal cancer surgery.

Methods

This was a retrospective, multicenter cohort study including 1273 patients that underwent left-sided or rectal cancer resection between 2009 and 2018 from three hospitals in the Netherlands. AL patients were 1:1 matched with non-leak patients and preoperative contrast-enhanced CT-scans were retrospectively analyzed for mesenteric atherosclerotic lesions. The main outcome measure was the presence of mesenteric occlusive disease on the preoperative CT-scan.

Results

Anastomotic leak developed in 6% of 1273 patients (N = 76). Low anterior resection and stage I–III disease were statistically significant associated with AL (p = 0.01, p = 0.04). No other statistically significant differences in patient characteristics between AL and non-leak patients were found. A clinically significant stenosis (≥ 70–100%) of the inferior mesenteric artery was statistically significant more frequent present in AL patients, compared to non-leak patients (p < 0.01). No statistically significant differences in the presence of mesenteric occlusive disease of the celiac artery and superior mesenteric artery between AL patients and non-leak patients were found.

Conclusion

Mesenteric occlusive disease of the IMA on preoperative CT-scan is associated with AL after left-sided colon or rectal resection for cancer. Preoperative identification of high-risk patients with a preoperative CT-scan of the mesenteric vasculature might be useful to reduce the risk of AL.
Outcomes of left atrial appendage occlusion vs. non-vitamin K antagonist oral anticoagulants in atrial fibrillation
Authors: Ding Wern Yew , Rivera-Caravaca José Miguel , Fazio-Eynullayeva Elnara , Underhill Paula , Gupta Dhiraj , Marín Francisco , Lip Gregory Y. H.
Published: January 2022

Background

The effects of left atrial appendage (LAA) occlusion compared to non-vitamin K antagonist oral anticoagulant (NOAC) therapy in patients with atrial fibrillation (AF) remain unknown.

Aims

We aimed to evaluate the outcomes in patients with AF who received LAA occlusion vs. NOAC therapy.

Methods

We utilised data from TriNetX which is a global federated health research network currently containing data for 88.5 million patients. ICD-10 codes were employed to identify AF patients treated with either LAA occlusion or NOAC between 1st December 2010 and 17th January 2019. Clinical outcomes of interest were analysed up to 2 years.

Results

108,697 patients were included. Patients who underwent LAA occlusion were younger, more likely to be white Caucasian and male, had a greater incidence of comorbidities, and were less likely to be prescribed other cardiovascular medications. Using propensity score matching, the risk of all-cause mortality was significantly lower among patients who received LAA occlusion compared to NOAC therapy [1.51% vs. 5.60%, RR 0.27 (95% CI 0.14–0.54)], but there were no statistical differences in the composite thrombotic or thromboembolic events [8.17% vs. 7.72%, RR 1.06 (95% CI 0.73–1.53)], ischaemic stroke or TIA [4.69% vs. 5.45%, RR 0.86 (95% CI 0.54–1.38)], venous thromboembolism [1.66% vs. 1.51%, RR 1.10 (95% CI 0.47–2.57)] and intracranial haemorrhage [1.51% vs. 1.51%, RR 1.00 (95% CI 0.42–2.39)].

Conclusion

Overall, LAA occlusion might be a suitable alternative to NOAC therapy for stroke prevention in patients with AF.

Graphical abstract
International practice variation in perioperative laboratory testing in glioblastoma patients—a retrospective cohort study
Authors: Senders Joeky T. , Maas Sybren L. N. , Draaisma Kaspar , McNulty John J. , Ashby Joanna L. , Hofer Imo , van Solinge Wouter W. , Berg Maarten ten , Snijders Tom J. , Seute Tatjana , Robe Pierre A. , Gormley William B. , Smith Timothy R. , Broekman Marike L. D.
Published: January 2022

Purpose

Although standard-of-care has been defined for the treatment of glioblastoma patients, substantial practice variation exists in the day-to-day clinical management. This study aims to compare the use of laboratory tests in the perioperative care of glioblastoma patients between two tertiary academic centers—Brigham and Women’s Hospital (BWH), Boston, USA, and University Medical Center Utrecht (UMCU), Utrecht, the Netherlands.

Methods

All glioblastoma patients treated according to standard-of-care between 2005 and 2013 were included. We compared the number of blood drawings and laboratory tests performed during the 70-day perioperative period using a Poisson regression model, as well as the estimated laboratory costs per patient. Additionally, we compared the likelihood of an abnormal test result using a generalized linear mixed effects model.

Results

After correction for age, sex, IDH1 status, postoperative KPS score, length of stay, and survival status, the number of blood drawings and laboratory tests during the perioperative period were 3.7-fold (p < 0.001) and 4.7-fold (p < 0.001) higher, respectively, in BWH compared to UMCU patients. The estimated median laboratory costs per patient were 82 euros in UMCU and 256 euros in BWH. Furthermore, the likelihood of an abnormal test result was lower in BWH (odds ratio [OR] 0.75, p < 0.001), except when the prior test result was abnormal as well (OR 2.09, p < 0.001).

Conclusions

Our results suggest a substantially lower clinical threshold for ordering laboratory tests in BWH compared to UMCU. Further investigating the clinical consequences of laboratory testing could identify over and underuse, decrease healthcare costs, and reduce unnecessary discomfort that patients are exposed to.
Assessing the wall effects of packed concentric cylinders and angular walls on granular bed porosity
Authors: Bandelt Riess Peter Michael , Briesen Heiko , Schiochet Nasato Daniel
Published: January 2022

The effect of added wall support on granular bed porosity is systematically studied to elucidate performance enhancements in filtration processes achieved by using inserts, as demonstrated experimentally (Bandelt Riess et al. in Chem Eng Technol 2018, 2021). Packed beds of spheres are simulated through discrete element method in cylinders with different internal wall configurations. Three containing systems are generated: concentric cylinders, angular walls, and a combination of both. Variations of particle size and wall friction and thickness are also considered, and the resulting granular bed porosities are analyzed. The porosity increase is proportional to the incorporated wall support; the combination of cylindrical and angular inserts displays the greatest effect (up to 26% increase). The sinusoidal porosity values near the walls are exhibited to clarify the effects. The presented method can change and evaluate granular bed porosity increments, which could lead to filtration process improvements, and the obtained behaviors and profiles can be used to explore additional effects and further systems.

Graphical abstract
Mirror self-recognition in gorillas (Gorilla gorilla gorilla): a review and evaluation of mark test replications and variants
Authors: Murray Lindsay E. , Anderson James R. , Gallup Gordon G.
Published: January 2022

Mirror self-recognition (MSR), widely regarded as an indicator of self-awareness, has not been demonstrated consistently in gorillas. We aimed to examine this issue by setting out a method to evaluate gorilla self-recognition studies that is objective, quantifiable, and easy to replicate. Using Suarez and Gallup’s (J Hum Evol 10:175–183, 1981) study as a reference point, we drew up a list of 15 methodological criteria and assigned scores to all published studies of gorilla MSR for both methodology and outcomes. Key features of studies finding both mark-directed and spontaneous self-directed responses included visually inaccessible marks, controls for tactile and olfactory cues, subjects who were at least 5 years old, and clearly distinguishing between responses in front of versus away from the mirror. Additional important criteria include videotaping the tests, having more than one subject, subjects with adequate social rearing, reporting post-marking observations with mirror absent, and giving mirror exposure in a social versus individual setting. Our prediction that MSR studies would obtain progressively higher scores as procedures and behavioural coding practices improved over time was supported for methods, but not for outcomes. These findings illustrate that methodological rigour does not guarantee stronger evidence of self-recognition in gorillas; methodological differences alone do not explain the inconsistent evidence for MSR in gorillas. By implication, it might be suggested that, in general, gorillas do not show compelling evidence of MSR. We advocate that future MSR studies incorporate the same criteria to optimize the quality of attempts to clarify the self-recognition abilities of gorillas as well as other species.
3D APT and NOE CEST-MRI of healthy volunteers and patients with non-enhancing glioma at 3 T
Authors: Wu Yulun , Wood Tobias C. , Arzanforoosh Fatemeh , Hernandez-Tamames Juan A. , Barker Gareth J. , Smits Marion , Warnert Esther A. H.
Published: January 2022

Objective

Clinical application of chemical exchange saturation transfer (CEST) can be performed with investigation of amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) effects. Here, we investigated APT- and NOE-weighted imaging based on advanced CEST metrics to map tumor heterogeneity of non-enhancing glioma at 3 T.

Materials and methods

APT- and NOE-weighted maps based on Lorentzian difference (LD) and inverse magnetization transfer ratio (MTRREX) were acquired with a 3D snapshot CEST acquisition at 3 T. Saturation power was investigated first by varying B1 (0.5–2 µT) in 5 healthy volunteers then by applying B1 of 0.5 and 1.5 µT in 10 patients with non-enhancing glioma. Tissue contrast (TC) and contrast-to-noise ratios (CNR) were calculated between glioma and normal appearing white matter (NAWM) and grey matter, in APT- and NOE-weighted images. Volume percentages of the tumor showing hypo/hyperintensity (VPhypo/hyper,CEST) in APT/NOE-weighted images were calculated for each patient.

Results

LD APT resulting from using a B1 of 1.5 µT was found to provide significant positive TCtumor,NAWM and MTRREX NOE (B1 of 1.5 µT) provided significant negative TCtumor,NAWM in tissue differentiation. MTRREX-based NOE imaging under 1.5 µT provided significantly larger VPhypo,CEST than MTRREX APT under 1.5 µT.

Conclusion

This work showed that with a rapid CEST acquisition using a B1 saturation power of 1.5 µT and covering the whole tumor, analysis of both LD APT and MTRREX NOE allows for observing tumor heterogeneity, which will be beneficial in future studies using CEST-MRI to improve imaging diagnostics for non-enhancing glioma.
Phosphorus fluxes in two contrasting forest soils along preferential pathways after experimental N and P additions
Authors: Julich Dorit , Makowski Vera , Feger Karl-Heinz , Julich Stefan
Published: January 2022

The assessment of impacts of an altered nutrient availability, e.g. as caused by consistently high atmospheric nitrogen (N) deposition, on ecosystem phosphorus (P) nutrition requires understanding of P fluxes. However, the P translocation in forest soils is not well understood and soil P fluxes based on actual measurements are rarely available. Therefore, the aims of this study were to (1) examine the effects of experimental N, P, and P+N additions on P fluxes via preferential flow as dominant transport pathway (PFPs) for P transport in forest soils; and (2) determine whether these effects varied with sites of contrasting P status (loamy high P/sandy low P). During artificial rainfall experiments, we quantified the P fluxes in three soil depths and statistically analyzed effects by application of linear mixed effects modeling. Our results show that the magnitude of P fluxes is highly variable: In some cases, water and consequently P has not reached the collection depth. By contrast, in soils with a well-developed connection of PFPs throughout the profile fluxes up to 4.5 mg P m−2 per experiment (within 8 h, no P addition) were observed. The results furthermore support the assumption that the contrasting P nutrition strategies strongly affected P fluxes, while also the response to N and P addition markedly differed between the sites. As a consequence, the main factors determining P translocation in forest soils under altered nutrient availability are the spatio-temporal patterns of PFPs through soil columns in combination with the P nutrition strategy of the ecosystem.
Geographic determinants of colorectal cancer in Louisiana
Authors: Danos Denise , Leonardi Claudia , Wu Xiao-Cheng
Published: January 2022

Purpose

Currently, rural residents in the United States (US) experience a greater cancer burden for tobacco-related cancers and cancers that can be prevented by screening. We aim to characterize geographic determinants of colorectal cancer (CRC) incidence in Louisiana due to rural residence and other known geographic risk factors, area socioeconomic status (SES), and cultural region (Acadian or French-speaking).

Methods

Primary colorectal cancer diagnosed among adults 30 years and older in 2008–2017 were obtained from the Louisiana Tumor Registry. Population and social and economic data were obtained from US Census American Community Survey. Rural areas were defined using US Department of Agriculture 2010 rural–urban commuting area codes. Estimates of relative risk (RR) were obtained from multilevel binomial regression models of incidence.

Results

The study population was 16.1% rural, 18.4% low SES, and 17.9% Acadian. Risk of CRC was greater among rural white residents (RR Women: 1.09(1.02–1.16), RR Men: 1.11(1.04–1.18)). Low SES was associated with increased CRC for all demographic groups, with excess risk ranging from 8% in Black men (RR: 1.08(1.01–1.16)) to 16% in white men (RR: 1.16(1.08–1.24)). Increased risk in the Acadian region was greatest for Black men (RR: 1.21(1.10–1.33)) and women (RR: 1.21(1.09–1.33)). Rural–urban disparities in CRC were no longer significant after controlling for SES and Acadian region.

Conclusion

SES remains a significant determinant of CRC disparities in Louisiana and may contribute to observed rural–urban disparities in the state. While the intersectionality of CRC risk factors is complex, we have confirmed a robust regional disparity for the Acadian region of Louisiana.
Dynamics of bacterial blight disease in resistant and susceptible rice varieties
Authors: Niones Jennifer T. , Sharp Ryan T. , Donayre Dindo King M. , Oreiro Eula Gems M. , Milne Alice E. , Oliva Ricardo
Published: January 2022

Bacterial blight (X. oryzae pv. oryzae) is a serious disease in rice across the world. To better control the disease, it is important to understand its epidemiology and how key aspects of this (e.g. infection efficiency, and spatial spread) change according to environment (e.g. local site conditions and season), management, and in particular, variety resistance. To explore this, we analysed data on the disease progress on resistant and susceptible varieties of rice grown at four sites in the Philippines across five seasons using a combination of mechanistic modelling and statistical analysis. Disease incidence was generally lower in the resistant variety. However, we found no evidence that the primary infection efficiency was lower in resistant varieties, suggesting that differences were largely due to reduced secondary spread. Despite secondary spread being attributed to splash dispersal which is exacerbated by wind and rain, the wetter sites of Pila and Victoria in south Luzon tended to have lower infection rates than the drier sites in central Luzon. Likewise, we found spread in the dry season can be substantial and should therefore not be ignored. In fact, we found site to be a greater determinant of the number of infection attempts suggesting that other environmental and management factors had greater effect on the disease than climate. Primary infection was characterised by spatially-random observations of disease incidence. As the season progressed, we observed an emerging short-range (1.6 m–4 m) spatial structure suggesting secondary spread was predominantly short-range, particularly where the resistant variety was grown.
Convexity and level sets for interval-valued fuzzy sets
Authors: Huidobro Pedro , Alonso Pedro , Janiš Vladimír , Montes Susana
Published: January 2022

Convexity is a deeply studied concept since it is very useful in many fields of mathematics, like optimization. When we deal with imprecision, the convexity is required as well and some important applications can be found fuzzy optimization, in particular convexity of fuzzy sets. In this paper we have extended the notion of convexity for interval-valued fuzzy sets in order to be able to cover some wider area of imprecision. We show some of its interesting properties, and study the preservation under the intersection and the cutworthy property. Finally, we applied convexity to decision-making problems.
Rethinking employability: how students build on interest in a subject to plan a career
Authors: Quinlan Kathleen M. , Renninger K. Ann
Published: January 2022

As universities prioritise employability, there is increased attention to promoting students’ career decidedness. In this mixed method, cross-sectional study, we explore whether and how students’ interest in their academic subject affects their career decidedness. Using surveys of 428 undergraduates studying sciences in a UK university (60% F, average age = 19.9) and case examples from follow-up interviews with 15 students, we examine students’ interest development and its relation to their career decidedness and their desire for meaningful, interesting work. Findings showed that most students who were studying science in university had a well-developed interest that had motivated their choice of programme, and their subject interest and career decidedness were linked. Regression analyses indicated that students’ interest in their subject was a significant predictor of career decidedness, mediated by students’ desire to pursue that interest in their career. Open-ended comments on the surveys suggested that decidedness was informed by coursework, proactive career exploration, work experience, interest, feasibility, and familial contacts. Interviews confirmed these factors and illustrated how they contributed to students’ career decidedness. We propose implications for academics and career counsellors who might help students refine their interest by considering connections between their academic subject, interest, and related career options. We argue that educators and policy-makers need to reframe employability interventions and think beyond teaching students skills or attributes that lead to employment. Educators can start with students’ interest in their subject and support students’ exploration of how they can continue to pursue that interest in various careers.
Role of microperimetry in evaluating disease progression in age-related macular degeneration: a scoping review
Authors: Madheswaran Gopinath , Nasim Pinaz , Ballae Ganeshrao Shonraj , Raman Rajiv , Ve Ramesh S.
Published: January 2022

Purpose

Recent research has found variable evidence on the role of mesopic and dark-adapted scotopic microperimetry assessment in age-related macular degeneration. This scoping review summarises how mesopic and scotopic microperimetry can be used to assess disease progression in age-related macular degeneration and identifies gaps in the literature.

Methods

A population, concept, and context approach was used to develop the search strategy. Ovid MEDLINE, EMBASE, Cochrane Library, PubMed, CINAHL Plus, Web of Science, and SCOPUS databases were used to conduct the literature search. The key search terms used in the databases were age-related macular degeneration and microperimetry.

Results

Twelve studies were eligible and included in the review. All the studies (n = 12) were conducted in European countries [Germany (9), Italy (2), and the United Kingdom (1)]. The mesopic and scotopic sensitivities were measured using the Nidek scotopic microperimeter (MP1-S) (n = 6), scotopic Macular Integrity Assessment device (S-MAIA) (n = 5), and both MP1-s and S MAIA (n = 1). 83.3% (n = 10) studied (cross-sectional design) on mesopic, scotopic microperimetry and found reduced rod (scotopic) photoreceptors sensitivities compared to cone (mesopic) photoreceptors sensitivities in patients with small and reticular pseudodrusen despite having good visual acuity. Only 16.7% (n = 2) of studies followed participants with reticular drusen/large drusen for three years (longitudinal design) and found reduced scotopic over mesopic sensitivity at baseline and localized mesopic with profound scotopic sensitivity loss during follow-ups.

Conclusion

Scotopic sensitivity is a better functional indicator than mesopic sensitivity to understand early and intermediate age-related macular degeneration progression. The evidence from longitudinal studies is debatable due to the limited stimuli range of existing microperimeters, smaller sample size, and lost follow-ups.
Brief Report: Evaluating the Diagnostic Yield of Commercial Gene Panels in Autism
Authors: Ní Ghrálaigh Fiana , McCarthy Ellen , Murphy Daniel N. , Gallagher Louise , Lopez Lorna M.
Published: January 2022

Autism is a prevalent neurodevelopmental condition, highly heterogenous in both genotype and phenotype. This communication adds to existing discussion of the heterogeneity of clinical sequencing tests, “gene panels”, marketed for application in autism. We evaluate the clinical utility of available gene panels based on existing genetic evidence. We determine that diagnostic yields of these gene panels range from 0.22% to 10.02% and gene selection for the panels is variable in relevance, here measured as percentage overlap with SFARI Gene and ranging from 15.15% to 100%. We conclude that gene panels marketed for use in autism are currently of limited clinical utility, and that sequencing with greater coverage may be more appropriate.
Creativity over time and space
Authors: Serafinelli Michel , Tabellini Guido
Published: January 2022

Creativity is often highly concentrated in time and space, and across different domains. What explains the formation and decay of clusters of creativity? We match data on notable individuals born in Europe between the eleventh and the nineteenth centuries with historical city data. The production and attraction of creative talent is associated with city institutions that protected economic and political freedoms and promoted local autonomy. Instead, indicators of local economic conditions such as city size and real wages, do not predict creative clusters. We also show that famous creatives are spatially concentrated and clustered across disciplines, that their spatial mobility has remained stable over the centuries, and that creative clusters are persistent but less than population.
Co-evolution patterns of university patenting and technological specialization in European regions
Authors: Caviggioli Federico , Colombelli Alessandra , De Marco Antonio , Scellato Giuseppe , Ughetto Elisa
Published: January 2022

This paper provides novel evidence on co-evolution patterns of the technological specialization of innovation activities of firms and academic institutions located in the same European region during the years from 2003 to 2014. We exploit a novel and unique dataset merging data on EU-funded R&D projects, universities, patents, and economic region-level data for a large sample of universities and firms co-located in geographical areas at the third level of the Nomenclature of Territorial Units for Statistics (NUTS3), which correspond to a sub-regional scale of analysis. Our results indicate the presence of substantial heterogeneity across the analyzed EU regions with respect to the co-evolution of industry and academia specializations. In particular, we find that the specialization into a new technological domain is led by the local academic research system only in a few cases. We also document that a number of factors, at both the university and region levels, are associated with convergent or divergent processes in the relative specialization of the innovation activities carried out by firms and universities co-located in the same region.
Using student feedback about the learning environment as a starting point for co-construction
Authors: Aldridge Jill M. , Bianchet Silvana
Published: January 2022

The context in which learning takes place, or learning environment, is pivotal to a positive learning experience for students. Although numerous studies have established strong links between a positive learning environment and a range of student outcomes, far less research has examined how teachers might establish such an environment. Amidst growing acknowledgment that opportunities for the co-construction of learning and assessment design could provide a means of developing a more positive learning environment, this case study examined one such journey. Using a case study approach, we argue that student feedback involving a learning environment survey provides a valuable starting point for including students in co-construction and classroom improvement. Our findings indicate that teachers can improve the learning environment by involving students in meaningful co-construction through open tasks.
Rewriting the History of Connexive Logic
Authors: Lenzen Wolfgang
Published: January 2022

The “official” history of connexive logic was written in 2012 by Storrs McCall who argued that connexive logic was founded by ancient logicians like Aristotle, Chrysippus, and Boethius; that it was further developed by medieval logicians like Abelard, Kilwardby, and Paul of Venice; and that it was rediscovered in the 19th and twentieth century by Lewis Carroll, Hugh MacColl, Frank P. Ramsey, and Everett J. Nelson. From 1960 onwards, connexive logic was finally transformed into non-classical calculi which partly concur with systems of relevance logic and paraconsistent logic. In this paper it will be argued that McCall’s historical analysis is fundamentally mistaken since it doesn’t take into account two versions of connexivism. While “humble” connexivism maintains that connexive properties (like the condition that no proposition implies its own negation) only apply to “normal” (e.g., self-consistent) antecedents, “hardcore” connexivism insists that they also hold for “abnormal” propositions. It is shown that the overwhelming majority of the forerunners of connexive logic were only “humble” connexivists. Their ideas concerning (“humbly”) connexive implication don’t give rise, however, to anything like a non-classical logic.
A General Theory of Location Based on the Notion of Entire Location
Authors: Correia Fabrice
Published: January 2022

It would be a good thing to have at our disposal a general theory of location that is neutral with respect to (i.e. that does not rule out or entail) (i) the view that some objects have more than one exact location, (ii) the view that some objects are located without having an exact location, and (iii) the view that some objects are “spanners”—where a spanner is an object exactly located at a region that has proper parts but which has no proper part exactly located at a proper part of the region. As far as I know, no theory of location that can be found in the literature has this feature. I put forward a new theory that does—or so I argue. The theory takes as its sole locational primitive the notion ofbeing entirely located at.
Tumor load rather than contrast enhancement is associated with the visual function of children and adolescents with optic pathway glioma – a retrospective Magnetic Resonance Imaging study
Authors: Kilian Anna , Aigner Annette , Simon Michèle , Salchow Daniel J. , Potratz Cornelia , Thomale Ulrich-Wilhelm , Hernáiz Driever Pablo , Tietze Anna
Published: January 2022

Introduction

Optic pathway gliomas are often asymptomatic tumors occurring in children with neurofibromatosis type 1 (NF1 + OPG) or sporadically (spOPG). Treatment is usually prompted by visual loss and/or tumor progression on MRI. The aim of this study was to investigate the relationship between visual acuity (VA), tumor growth, and contrast enhancement to provide more distinct indications for the administration of gadolinium-based contrast agents.

Methods

Tumor load was retrospectively measured and enhancement semi-quantitatively scored on 298 MRIs of 35 patients (63% NF1 + OPG). Spearman rank correlation between tumor load and enhancement was calculated and a linear mixed model used to examine the influence of tumor load and enhancement on corresponding VA tests (LogMAR).

Results

The optic nerve width in NF1 + OPGs was strongly associated with VA (regression coefficient 0.75; confidence interval 0.61—0.88), but weakly with enhancement (0.06; −0.04—0.15). In spOPGs, tumor volume and optic nerve width were more relevant (0.31; −0.19—0.81 and 0.39; 0.05—0.73) than enhancement (0.09; −0.09—0.27).

Conclusions

Tumor load measures may be more relevant for the surveillance of optic pathway gliomas than enhancement, given that VA is the relevant outcome parameter. Regular contrast administration should therefore be questioned in these patients.
When Do Voters Respond to Campaign Finance Disclosure? Evidence from Multiple Election Types
Authors: Robinson Thomas S.
Published: January 2022

In recent American elections political candidates have actively emphasized features of their fundraising profiles when campaigning. Yet, surprisingly, we know comparatively little about how financial information affects vote choice specifically, whether effects differ across types of election, and how robust any effects are to other relevant political signals. Using a series of conjoint experiment designs, I compare the effects of campaigns’ financial profiles on vote choice across direct democratic and representative elections, randomizing subjects’ exposure to additional political cues. I find that while the financial profile of candidates can affect vote choice, these effects are drowned out by non-financial signals. In ballot initiative races, the explicit policy focus of the election appears to swamp any effect of financial information. This paper is the first to explore the comparative effects of financial disclosure across election type, contributing to our understanding of how different heuristics interact across electoral contexts.
Inhibition of the urea-urease reaction by the components of the zeolite imidazole frameworks-8 and the formation of urease-zinc-imidazole hybrid compound
Authors: Német Norbert , Miele Ylenia , Shuszter Gábor , Tóth Eszter L. , Maróti János Endre , Szabó Péter János , Rossi Federico , Lagzi István
Published: January 2022

In the past decade, much effort has been devoted to using chemical clock-type reactions in material design and driving the self-assembly of various building blocks. Urea-urease enzymatic reaction has chemical pH clock behavior in an unbuffered medium, in which the induction time and the final pH can be programmed by the concentrations of the reagents. The urea-urease reaction can offer a new alternative in material synthesis, where the pH and its course in time are crucial factors in the synthesis. However, before using it in any synthesis method, it is important to investigate the possible effects of the reagents on the enzymatic reaction. Here we investigate the effect of the reagents of the zeolite imidazole framework-8 (zinc ions and 2-methylimidazole) on the urea-urease reaction. We have chosen the zeolite imidazole framework-8 because its formation serves as a model reaction for the formation of other metal–organic frameworks. We found that, besides the inhibition effect of the zinc ions which is well-known in the literature, 2-methylimidazole inhibits the enzymatic reaction as well. In addition to the observed inhibition effect, we report the formation of a hybrid urease-zinc-2-methylimidazole hybrid material. To support the inhibition effect, we developed a kinetic model which reproduced qualitatively the experimentally observed kinetic curves.