bluuebunny/crossref_metadata_2025 huggingface dataset:
Audit firm tenure and corporate tax avoidance: evidence spanning COVID-19 pandemic
Authors: Kamarudin Khairul Anuar , Wan Ismail Wan Adibah , Harymawan Iman , Mohamad Ariff Akmalia
Published: May 2024

Purpose

This study aims to examine the effect of audit firm tenure (AFT) on corporate tax avoidance (CTA) and the moderating effect of the COVID-19 pandemic.

Design/methodology/approach

The sample comprises 41,074 firm-year observations from 32 countries from 2015 to 2020, for which data are collected from various sources: financial data from the Refinitiv database, country corporate tax rates from the Tax Foundation, and other country-level data from the World Bank database. The authors use the book tax difference to measure CTA and multiple proxies for AFT.

Findings

This study finds that a longer AFT is associated with higher CTA, confirming the notion that long AFT impairs auditor independence. The findings remain robust when considering various AFT proxies, incorporating Hofstede’s cultural factors, using weighted least-squares estimation and addressing endogeneity through propensity score matching. This study also finds a non-linear relationship between extended client and auditor relationships and CTA, supporting the mandatory audit firm rotation regulation and increasing investors’ caution regarding the consequences of extended client–auditor relationships on firm behaviour.

Research limitations/implications

This study offers new evidence on the effect of the COVID-19 pandemic on the link between AFT and CTA and documents a non-linear relationship between AFT, which has not been addressed in prior studies.

Practical implications

The findings of this study have several significant practical implications. First, governments and policymakers gain insights into the consequences of extended auditor–client relationships, hence calling for a review of auditing and taxation regulations. Second, the findings provide important insights into the issue of auditor independence, especially during long engagements and crises such as COVID-19. Finally, investors and tax authorities should be more cautious about the risks of aggressive tax avoidance during crisis periods.

Originality/value

To the best of the authors’ knowledge, this is the first study to use a global data set to investigate the effect of AFT on CTA during the COVID-19 pandemic.
Selection of a business school dean: a multi-criteria knowledge-based approach
Authors: Kheybari Siamak , Ishizaka Alessio , Mehrpour Mohammad Reza , Pereira Vijay
Published: May 2024

Purpose

Business schools play a significant role in providing individuals with the ability to adapt to constantly changing environments. Such agile organizations require deans who, as leaders, possess the knowledge and attributes of astute and responsible executives. In this regard, the measurement of the attributes of leadership paves the way for evaluating a leader’s options process. In this study, we measure the attributes of leadership to pave the way for evaluating a leader’s decision-making process.

Design/methodology/approach

The rich data included the opinions of 93 university professors from seven countries: Iran, India, China, France, the UK, Canada and the USA. In appraising the responses, the authors considered the nationality and the development level of each participant’s country and continent. In this study, the authors developed an online questionnaire based on the best-worst method (BWM). By performing a one-way analysis of variance (ANOVA), the authors also determined the significant statistical differences of the scientific communities through the lenses of authentic leadership, leader-member exchange and social identity and leadership.

Findings

The results provide evidence of transparency, measured as the most important criterion for leading a business school, i.e. knowledgeable deanship. Furthermore, the findings reveal a meaningful difference between developed and developing countries in the context of an authentic leadership pillar.

Originality/value

This paper contributed to the literature in five major ways as follows: The authors investigated the attitudes of scientific communities from different countries, business schools, BWM, dean selection and leadership evaluation.By means of the BWM, the authors measured the criteria culminating in the selection of a knowledgeable leader for a business school.The authors compared and contrasted the attitudes of scientific communities in developing countries vis-à-vis those in developed ones.The authors addressed the differences and similarities among countries in relation to the selection of a knowledgeable business school leader.The authors provided beneficial insights by addressing the different perspectives of researchers on the weights of the criteria involved in the selection procedure for a business school dean.
The influence of local government transparency on the implementation of the sustainable development goals in municipalities
Authors: Ríos Ana-María , Guillamón María-Dolores , Benito Bernardino
Published: May 2024

Purpose

Nowadays, there is a strong public interest in promoting transparency to be informed about the actions of the public sector. At the same time, there has been a significant change in society’s perceptions and concerns about sustainable development, with a marked increase in attention to this area. In this context, our main objective is to investigate the impact of transparency practices in local government on the implementation of the Sustainable Development Goals (SDGs) in Spanish municipalities.

Design/methodology/approach

We will analyse a sample of 84 municipalities, using the Dynamic Transparency Index published by Dyntra to measure transparency. For the level of implementation of the SDGs, we will use an index specifically created using data from the report “The SDGs in 100 Spanish Cities”, published by the Spanish Network for Sustainable Development in 2020.

Findings

Municipalities with a larger dependent population tend to achieve higher SDG levels. Municipalities with lower financial surpluses and more self-generated resources show better SDG implementation. Progressive political parties lean more towards sustainability, and coalition governments show higher SDG implementation than majority governments. Gender appears to play a minor role in SDG implementation, but male leadership is associated with higher levels. Factors such as population density and government transfers do not have a significant impact on SDG implementation levels.

Originality/value

This study seeks to address the lack of empirical research on the potential impact of transparency on the achievement of the SDGs, while also taking into account other socio-economic, financial and political aspects of the municipality. In doing so, it also contributes to the limited empirical literature on the determinants of the level of SDG implementation in local governments.
Accessibility of digital systems in information retrieval by users with visual impairment
Authors: Kiambati Fridah Gatwiri , Juma Samuel Wanyonyi , Wawire Brenda Aromu
Published: May 2024

Purpose

This paper aims to evaluate the accessibility of digital information systems as a key usability attribute in information retrieval by users with visual impairment (VI), to inform development of accessible information systems.

Design/methodology/approach

This study used a cross-sectional survey design based on the quantitative research paradigm. Data was collected from 117 students with visual impairments from selected public universities in Kenya, using a semi-structured questionnaire adapted from Web Content Accessibility Guidelines.

Findings

This study revealed that gender did not influence screen reader compatibility, alternative format preferences, perceptions of accessible content or digital library navigability. Instead, type of visual impairment, prior assistive technology (AT) training and digital library use frequency significantly impacted these attributes. Blind students reported positive experiences, favouring alternative formats, and expressed positive views on accessible content while those with low vision faced more challenges. Prior training in assistive technology and frequent digital library use resulted in higher screen reader compatibility and better navigability. Increased digital library use was linked to access to alternative content for those with prior assistive technology training.

Research limitations/implications

This study contributes to the existing literature on accessibility of digital information systems for users with visual impairments. Further research is needed to explore other factors that may influence the accessibility of digital systems, such as the design of user interfaces as well as an evaluation of accessibility of digital systems for other categories of disabilities such as hearing impairment, physical impairment, autism and intellectual disability, among others.

Practical implications

The findings of this study have practical implications for the design and development of digital systems such as digital libraries. Developers can leverage findings of this study to enhance compatibility of digital platforms with screen readers and provide alternative formats and accessible content. User-centred design principles can be used to create interfaces that are easy to navigate and friendly to users with visual impairments. Training programmes on assistive technology should be provided to users to enhance their skills and confidence in using digital systems.

Originality/value

This study contributes towards design and creation of navigable systems that are compatible with screen readers. The study also points out the importance of creating more inclusive and usable digital environments for persons with visual impairments.
Implementation of design approach in traditional attire Bodo Dokhona for the sustainability of apparel culture
Authors: Brahma Chaitali , Saha Bhaskar , Chowdhury Anirban
Published: May 2024

Purpose

The purpose of this study is to empower a tradition Bodo attire Dokhona skilled artisan for their livelihoods and preserve cultural and historical legacy by using new themes influenced by Bodo items.

Design/methodology/approach

To revive the traditional Bodo artefacts by adapting a varied form of motifs inspired from Bodo artefacts which showcases Bodo identity.

Findings

Motifs implemented in apparel (e.g. Dokhona) inspired from Bodo traditional tools and musical instruments, signifying Bodo identity. Such apparels could be purchased by Bodo consumers as they are very keen to sustain their culture and heritage through motifs weaved in their traditional apparel. This study also proves that Dokhona designed with novel motifs developed from traditional artefacts are better than currently available designs of Dokhona as these were more aesthetic and contemporary in look.

Social implications

The motif adapted from traditional artefacts would motivate the weavers to weave innovative motif designs in their apparel bringing some newness in the Bodo traditional attire Dokhona, leads to business and women empowerment.

Originality/value

This study showed the way to create innovative ideas for designing apparel (e.g. Dokhona) from cultural artefacts and helps prospective textile and apparel designers to design sustainable Dokhona.
On Neoliberalism and Institutions: A Response to Michael Jacobs
Authors: Hodgson Geoffrey M.
Published: May 2024

In his article in this journal, Michael Jacobs lists the multiple overlapping crises which now affect the world. These include climate change and rising economic inequality. This comment endorses his emphasis on institutions and his call for richer institutional analyses to help develop viable policies to deal with these problems. But, on the other hand, this comment criticises his use of the term ‘neoliberalism’ to identify a major source of our current difficulties. Many ‘neoliberals’ are said to favour market solutions. But the term has become so vague that it is linked to not only economists such as Milton Friedman and Friedrich Hayek, but also to others who accept some markets in a mixed economy. Opposition to ‘neoliberalism’ then involves a rejection of market reforms in economies such as China and of mixed economies more generally. The word now means so many different things that it has becomes unusable.
The shadow economy, natural resource income, and the effect of economic globalization on carbon emissions: Toward a sustainable future
Authors: Li Xueyao , Lau Wei Theng , Law Siong Hook , Li Linwei
Published: May 2024

The shadow economy, natural resources, and economic globalization are interconnected factors that shape global carbon emissions. Developing effective strategies to mitigate climate change and achieve sustainable development requires understanding the interplay between these factors. This study examines the impact of the shadow economy, natural resource income, and economic globalization on CO2 emissions in APEC countries from 1990 to 2022. The empirical evidence suggests that a 1% increase in the shadow economy leads to a corresponding increase of 0.0861% in CO2 emissions. Economic growth, shadow economy, and economic globalization are positively associated with CO2 emissions in APEC countries. However, electricity supply from renewable sources and income from natural resources are negatively associated with CO2 emissions. Several policy implications need to be considered to address the shadow economy and its potential impact on CO2 emissions in APEC countries. Strengthening the enforcement of environmental laws and regulations is crucial in preventing the shadow economy's negative environmental impact. This includes targeting illegal activities such as logging, poaching, and dumping, which contribute to carbon emissions. Encouraging the transition to clean and sustainable energy sources can help mitigate the shadow economy's contribution to CO2 emissions.
Cardiac substructure delineation in radiation therapy – A state‐of‐the‐art review
Authors: Finnegan Robert N , Quinn Alexandra , Booth Jeremy , Belous Gregg , Hardcastle Nicholas , Stewart Maegan , Griffiths Brooke , Carroll Susan , Thwaites David I
Published: May 2024

Delineation of cardiac substructures is crucial for a better understanding of radiation‐related cardiotoxicities and to facilitate accurate and precise cardiac dose calculation for developing and applying risk models. This review examines recent advancements in cardiac substructure delineation in the radiation therapy (RT) context, aiming to provide a comprehensive overview of the current level of knowledge, challenges and future directions in this evolving field. Imaging used for RT planning presents challenges in reliably visualising cardiac anatomy. Although cardiac atlases and contouring guidelines aid in standardisation and reduction of variability, significant uncertainties remain in defining cardiac anatomy. Coupled with the inherent complexity of the heart, this necessitates auto‐contouring for consistent large‐scale data analysis and improved efficiency in prospective applications. Auto‐contouring models, developed primarily for breast and lung cancer RT, have demonstrated performance comparable to manual contouring, marking a significant milestone in the evolution of cardiac delineation practices. Nevertheless, several key concerns require further investigation. There is an unmet need for expanding cardiac auto‐contouring models to encompass a broader range of cancer sites. A shift in focus is needed from ensuring accuracy to enhancing the robustness and accessibility of auto‐contouring models. Addressing these challenges is paramount for the integration of cardiac substructure delineation and associated risk models into routine clinical practice, thereby improving the safety of RT for future cancer patients.
Identification of Prominin‐2 as a new player of cardiomyocyte senescence in the aging heart
Authors: Maggiorani D. , Santin Y. , Formoso K. , Drapé E. , Martini H. , Brun S. , Cousin G. , Lairez O. , Lezoualc'h F. , Parini A. , Douin‐Echinard V. , Mialet‐Perez J.
Published: May 2024

The aging heart is characterized by a number of structural changes leading to ventricular stiffness, impaired resistance to stress and increased risk of developing heart failure (HF). Genetic or pharmacological removal of senescent cells has recently demonstrated the possibility to relieve some cardiac aging features such as hypertrophy and fibrosis. However, the contribution of the different cell types in cardiac aging remains fragmentary due to a lack of cell‐specific markers. Cardiomyocytes undergo post‐mitotic senescence in response to telomere damage, characterized by persistent DNA damage response and expression of the classical senescence markers p21 and p16, which are shared by many other cell types. In the present study, we used transcriptomic approaches to discover new markers specific for cardiomyocyte senescence. We identified Prominin2 (Prom2), encoding a transmembrane glycoprotein, as the most upregulated gene in cardiomyocytes of aged mice compared to young mice. We showed that Prom2 was upregulated by a p53‐dependent pathway in stress‐induced premature senescence. Prom2 expression correlated with cardiomyocyte hypertrophy in the hearts of aged mice and was increased in atrial samples of patients with HF with preserved ejection fraction. Consistently, Prom2 overexpression was sufficient to drive senescence, hypertrophy and resistance to cytotoxic stress while Prom2 shRNA silencing inhibited these features in doxorubicin‐treated cardiac cells. In conclusion, we identified Prom2 as a new player of cardiac aging, linking cardiomyocyte hypertrophy to senescence. These results could provide a better understanding and targeting of cell‐type specific senescence in age‐associated cardiac diseases.
Centralized climate clubs and decentralized governance: A model of global CO2 mitigation
Authors: Nath Shyam , Madhoo Yeti Nisha
Published: May 2024

This paper extends the climate literature by examining the feasibility of integrating sub‐national governance into global club governance for mitigating CO2 emissions. Global climate clubs become an argument for having separate bundles of emission targets and incentive mechanisms in the form of opportunities for climate finance and technology sharing among the club members. An exploratory analysis is important to examine the role of import and export taxes and other channels, such as the clean development mechanism, in meeting the objective of nonmember countries to join the club. The crux, however, is how, after determining national‐level quotas, the mitigation responsibilities are shared with subnational entities. We propose a design of a carbon entry tax at the subnational level, namely states, districts, and municipalities. The carbon entry tax uses the nighttime luminosity data published by NASA as a measure of carbon, which constitutes the tax base. The carbon entry tax serves as a fiscal instrument of decarbonization in a decentralized framework.
Metformin use in pregnancy: What about long‐term effects in offspring?
Authors: Toft Johanne Holm , Økland Inger
Published: May 2024

Metformin use in pregnancy is increasing worldwide. Unlike insulin, metformin crosses the placenta. Consequently, maternal and fetal concentrations are comparable. Teratogenic effects are not reported, nor are adverse pregnancy outcomes. Reduced risk of hypertensive disorders, hypoglycemia, and macrosomia are potential benefits, together with lower gestational weight gain. Although metformin has been prescribed for pregnant women during the last 40 years, long‐term data regarding offspring outcomes are still lacking. Independent of maternal glycemic control, recent meta‐analyses report lower birthweight but accelerated postnatal growth and higher body mass index in metformin‐exposed children. The longest follow‐up study of placebo‐controlled metformin exposure in utero found an increased prevalence of central adiposity and obesity among children 5–10 years old. Recently, a Danish study reported a threefold increased risk of genital anomalies in boys, whose fathers used metformin around the time of conception. This commentary addresses the current controversies on metformin use in pregnancy.
Efficacy of a theory‐based and setting‐based intervention in promoting strength training among older adults in Hong Kong: A clustered randomized controlled trial
Authors: Mo Phoenix K. H. , Xie Luyao , Fong Vivian W. I. , Sum Raymond K. W. , Leung Elean F. L. , Wong Sam W. S. , Kwok Timothy C. Y. , Lau Joseph T. F.
Published: May 2024

The present study aimed to examine the efficacy of an intervention, based on the Health Belief Model (HBM) and social support, in promoting strength training (ST) among older adults. A two‐arm clustered randomized controlled trial (RCT) was conducted among 235 older adults from eight elderly centers in Hong Kong. The intervention group engaged in a 6‐month intervention comprising ST sessions, exercise consultations, social gatherings, and a buddy program, while the control group participated in social gatherings. Assessments were conducted at baseline (Month 0), post‐intervention (Month 6), and 3‐month follow‐up (Month 9), with primary outcome being the prevalence of meeting the American College of Sports Medicine (ACSM) recommendations of ST. Results showed that the intervention group reported significantly higher prevalence of meeting ACSM recommendations for ST at both post‐intervention and follow‐up. Linear mixed models showed significant interaction effect between condition and time on perceived susceptibility of sarcopenia and muscle strength and significant condition effect on self‐efficacy for ST, perceived severity of sarcopenia, perceived barriers of ST, and intention to perform ST. Findings suggest that the intervention, guided by HBM and social support, improves older adults' ST participation, muscle strength, perceptions on sarcopenia, and self‐efficacy for ST, which offers great potential for broader application in other settings.
Authentic leaders, energized employees? Indirect beneficial and adverse effects of authentic leadership on intrinsic motivation and exhaustion
Authors: Maunz Lucas A. , Thal Sascha , Glaser Jürgen
Published: May 2024

Current research is unclear regarding the associations between authentic leadership (AL), intrinsic motivation, and exhaustion. Following self‐determination theory (SDT), we hypothesize that AL indirectly increases intrinsic motivation and decreases exhaustion by increasing basic psychological need satisfaction (BPNS). We propose that these processes occur through increased AL in leader‐employee interactions and a higher average display of AL. To test these hypotheses, we conducted three studies using a mixed‐methods approach. Results of Study 1 (cross‐sectional survey; N = 597) supported the indirect effects of AL on employees' intrinsic motivation and exhaustion via BPNS. Study 2 (experience sampling; two samples, replication, Ns = 63; 128 observations = 231; 460) supported the indirect effects of AL experiences in daily leader‐employee interactions. Study 3 (semi‐structured interviews; N = 38) provided additional support for the proposed effects. However, Study 3 also showed potential adverse effects of AL. Some employees perceived a fully open leader as irritating, exhausting, and damaging to the job climate, particularly, when leaders violated role expectations and engaged in hostile behaviors. As these adverse effects were rare, we conclude that the beneficial effects of increased and higher average AL on employees' BPNS, motivation, and exhaustion outweigh the adverse effects.
Editorial: Making lower GI endoscopy referrals more FIT for purpose
Authors: Gettigan Neasa Mc , Valori Roland
Published: May 2024

LINKED CONTENT

This article is linked to Beaton et al papers. To view these articles, visit https://doi.org/10.1111/apt.18003
Ethical challenges in health care during collective hunger strikes in public or occupied spaces
Authors: Haselwarter Dominik , Kuehlmeyer Katja , Wild Verina
Published: May 2024

Public collective hunger strikes take place in complex social and political contexts, require medical attention and present ethical challenges to physicians. Empirical research, the ethical debate to date and existing guidelines by the World Medical Association focus almost exclusively on hunger strikes in detention. However, the public space differs substantially with regard to the conditions for the provision of health care and the diverse groups of healthcare providers or stakeholders involved. By reviewing empirical research on the experience of health professionals with public collective hunger strikes, we identified the following ethical challenges: (1) establishment of a trustful physician–striker relationship, (2) balancing of medico‐ethical principles in medical decision‐making, (3) handling of loyalty conflicts and (4) preservation of professional independence and the risk of political instrumentalization. Some of these challenges have already been described and discussed, yet not contextualized for public collective strikes, while others are novel. The presence of voluntary physicians may offer opportunities for a trustful relationship and, hence, for ethical treatment decisions. According to our findings, it requires more attention to how to realise autonomous medical decisions in the complex context of a dynamic, often unstructured and politically charged setting, which ethical norms should shape the professional role of voluntary physicians, and what is the influence of the hunger strikers' collective on individual healthcare decisions. Our article can serve as a starting point for further ethical discussion. It can also provide the basis for the development of potential guidelines to support health professionals involved in public collective hunger strikes.
Considerations for anti‐PD1‐based first‐line treatment of Hodgkin lymphoma
Authors: Bröckelmann Paul J.
Published: May 2024

Anti‐PD1‐based first‐line treatment holds great promise in classical Hodgkin lymphoma. The management of immune‐related adverse events in the context of time‐limited combined checkpoint blockade and chemotherapy administered in curative intent is a challenge. Kuczmarski and Lynch provide a case‐based approach to key toxicities observed in this setting.

Commentary on: Kuczmarski et al. Managing common toxicities associated with checkpoint inhibitor and chemotherapy combinations for untreated classic Hodgkin lymphoma. Br J Haematol 2024;205:100–108.
Market power and income disparities: How can firms influence the gap between capital and labor earnings
Authors: Amountzias Chrysovalantis
Published: May 2024

This paper investigates the effects of market power on income disparities when firm‐specific parameters are considered to test how they shape the gap between capital and labor earnings through their pricing decisions. The dataset consists of 2895 UK manufacturing and services firms over 2010–2019. The results provide the following insights: (a) There is a strong positive association between market power and income disparities across the market, (b) liquidity constraints exert a positive effect on the asset‐based disparities ratio, but a negative effect on the profit‐based ratio. The robustness of the results is also checked when market‐specific characteristics are included in the process.
Immigration and Physical Discipline of Children: The Influence of Generational Status and Culture
Authors: Muniz Caitlyn N. , Curry Theodore R.
Published: May 2024

This research examines whether physical punishment towards children in Méxican immigrant and native‐born Latinx families of Mexican heritage households varies across immigrant generational status and if physical punishment is associated with important measures of culture: familismo, traditional machismo, acculturation to the United States and enculturation to México. Data from a sample of households in El Paso County, Texas, are analysed using Firth logistic regression. Findings show that physical punishment is lowest in first‐generation immigrant households but, in sharp contrast, highest in 1.5‐generation immigrant households, suggesting the need for more precise measurement of immigration status as such differentiation can be masked with a more general approach to measuring immigrant generation. Findings also indicate that enculturation to México is protective towards physical punishment, while measures of acculturation, familismo and traditional machismo are not associated with this behaviour in multivariate models.
A city of newcomers: Migration and solidarity in the former East Germany
Authors: Fox Samantha Maurer
Published: May 2024

This article examines how urban temporalities have come to alternately foster and hinder migrants' incorporation into the larger social body. It draws on ethnographic and archival research conducted in Eisenhüttenstadt, Germany, and focuses on the so‐called “migrant crisis” of 2015, which resonated with earlier migration histories in the region. When Eisenhüttenstadt was founded in 1950, nearly one‐third of its residents were naturalized East German citizens. Yet under the socialist regime, any acknowledgment of their migration background was expressly forbidden and perceived as a threat to Eastern Bloc geopolitical alliances. Around 2015, however, this history reemerged, first at the local cultural history museum and later, in public discourse. This article attends to the shifting positionality of migration histories within the context of the former East Germany, which was perceived as European in a global context but post‐socialist in a German context. In doing so, it reveals how tensions between individual and urban futurities influence solidarity, integration, and national belonging.
The causal relationship between sarcopenia‐related traits and ischemic stroke: Insights from univariable and multivariable Mendelian randomization analyses
Authors: Song Jiahao , Zhou Da , Li Jingrun , Wang Mengqi , Jia Lina , Lan Duo , Song Haiqing , Ji Xunming , Meng Ran
Published: May 2024

Aims

The causal relationship between sarcopenia‐related traits and ischemic stroke (IS) remains poorly understood. This study aimed to explore the causal impact of sarcopenia‐related traits on IS and to identify key mediators of this association.

Methods

We conducted univariable, multivariable two‐sample, and two‐step Mendelian randomization (MR) analyses using genome‐wide association study (GWAS) data. This included data for appendicular lean mass (ALM), hand grip strength (HGS), and usual walking pace (UWP) from the UK Biobank, and IS data from the MEGASTROKE consortium. Additionally, 21 candidate mediators were analyzed based on their respective GWAS data sets.

Results

Each 1‐SD increase in genetically proxied ALM was associated with a 7.5% reduction in the risk of IS (95% CI: 0.879–0.974), and this correlation remained after controlling for levels of physical activity and adiposity‐related indices. Two‐step MR identified that six mediators partially mediated the protective effect of higher ALM on IS, with the most significant being coronary heart disease (CHD, mediating proportion: 39.94%), followed by systolic blood pressure (36.51%), hypertension (23.87%), diastolic blood pressure (15.39%), type‐2 diabetes mellitus (T2DM, 12.71%), and low‐density lipoprotein cholesterol (7.97%).

Conclusion

Our study revealed a causal protective effect of higher ALM on IS, independent of physical activity and adiposity‐related indices. Moreover, we found that higher ALM could reduce susceptibility to IS partially by lowering the risk of vascular risk factors, including CHD, hypertension, T2DM, and hyperlipidemia. In brief, we elucidated another modifiable factor for IS and implied that maintaining sufficient muscle mass may reduce the risk of such disease.
Local State Capacity and Uneven Taxation across Industrial Firms
Authors: Hou Linke , Liu Zhikuo , Zhang Qi , Zhao Xiaolu
Published: May 2024

In this research we investigate the association between local state capacity (LSC) and effective tax burdens (ETBs) on industrial firms within counties between 1998 and 2013. The LSC measures a state's capacity for policy implementation and specifically its ability to acquire low‐cost agricultural land for nonagricultural (industrial or commercial) purposes. Based on China's government‐led development experience since the 1990s, we draw on two unique household survey datasets to capture LSC at county level. We find robust evidence that greater LSC was associated with much lower ETBs on large industrial firms. This taxation pattern implies local government's primary reliance on larger manufacturing firms, while the ETBs for small‐and‐medium enterprises are not as prominently addressed. This research highlights that LSC can affect both the amount of revenue a local government can generate and the methods it uses to collect these revenues.
Total and H‐specific growth/differentiation factor 15 levels are unaffected by liraglutide or naltrexone/bupropion administration
Authors: Konstantinidou Sofia K. , Argyrakopoulou Georgia , Simati Stamatia , Stefanakis Konstantinos , Kokkinos Alexander , Analitis Antonis , Mantzoros Christos S.
Published: May 2024

Aim

To investigate growth/differentiation factor 15 (GDF‐15) levels in response to antiobesity medications, namely, liraglutide (Lira) and naltrexone/bupropion (N/B), in individuals with overweight or obesity.

Materials and Methods

This was a prospective, non‐randomized clinical trial with a two‐arm, parallel design. A total of 42 individuals with overweight or obesity without type 1 or type 2 diabetes mellitus were enrolled. The participants received either Lira 3 mg or N/B 32/360 mg, along with diet and exercise, according to comorbidities, cost and method of administration. Participants underwent clinical and laboratory measurements at baseline, as well as at the 3‐ and 6‐month time points. Anthropometric measurements and body composition analysis via bioelectrical impendence analysis were performed. Total blood samples for GDF‐15 and H‐specific GDF‐15 were collected in the fasting state and every 30 min for 3 h after the consumption of a standardized mixed meal.

Results

Overall, participants' weight was reduced by 9.29 ± 5.34 kg at Month 3 and 11.52 ± 7.52 kg at Month 6. Total and H‐specific GDF‐15 levels did not show significant changes during the mixed meal compared to values before the meal when all participants were examined at baseline, and at 3 and 6 month follow‐ups. No statistical significance was found when participants were examined by subgroup (Lira vs. N/B). No significant differences between treatment groups in postprandial area under the curve (AUC) or incremental AUC values were found at baseline or in the follow‐up months with regard to total and H‐specific GDF‐15 levels.

Conclusion

Neither total nor H‐specific GDF‐15 levels are affected by Lira or N/B treatment in patients with overweight or obesity.
Efficacy of revascularization in CTO patients based on hibernating myocardium therapy
Authors: Chen Wenjie , Du Zhiyong , Qin Yanwen , Zheng Ze , Liu Jinghua , Shi Yuchen
Published: May 2024

Background

The effectiveness of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) is still uncertain, especially for patients with ischemic left ventricular dysfunction. This study aimed to assess hibernating myocardium (HM), as determined by single‐photon emission computed tomography (SPECT) and 18F‐FDG positron emission tomography (PET), and to compare the benefits of PCI and optimal medical therapy (OMT).

Methods

A retrospective study collected data from 332 patients with CTO and ischemic left ventricular dysfunction. The study compared patients who underwent PCI or OMT via propensity score matching (PSM) analysis which was performed with a 1:2 matching protocol using the nearest neighbour matching algorithm. The primary endpoint of the study was the occurrence of major adverse cardiac events (MACE), defined as a composite of cardiac death, readmission for worsening heart failure (WHF), revascularization and myocardial infarction (MI).

Results

After PSM, there were a total of 246 individuals in the PCI and OMT groups. Following Cox regression, hibernating myocardium/total perfusion defect (HM/TPD) was identified as an independent risk factor (hazard ratio (HR): 1.03, 95% confidence interval (CI): 1.008–1.052, p = .007). The cut‐off value of HM/TPD was 38%. The results of the subgroup analysis suggest that for patients with HM/TPD >38%, the OMT group had a greater risk of MACE (p = .035). A sensitivity analysis restricting patients with single‐vessel CTO lesions, HM/TPD remained an independent predictor (HR 1.025, 95% CI 1.008–1.043, p = .005).

Conclusion

HM/TPD is an independent predictor of MACE, and for patients with HM/TPD > 38%, CTO‐PCI had a lower risk of MACE compared with OMT. However, further validation is still needed through large‐scale studies.
Beyond workplace‐related issues: How Global Unions use digital activism to engage in social agenda‐setting
Authors: Ford Michele , Sinpeng Aim
Published: May 2024

Digital information and communications technologies like social media are critical for trade union renewal. Yet, although many unions now use social media, there remain ongoing debates as to what effective digital activism looks like. This question is even more pressing for the Global Unions, as international labour movement organizations without grassroots members. Drawing on social movement and networked communication theories, this article interrogates Global Unions’ social media practices through a mixed‐method analysis of 19,009 Facebook posts created between 2017 and 2022. Based on this analysis, we find that Global Unions that adopt crowd‐focused communication styles and post on broader social issues have more success in engaging with online crowds than those that emphasize workplace or organizational issues and adopt top‐down communication styles. At the same time, our findings challenge assumptions in the literature that crowd‐led, connective communication styles associated with engagement are necessarily the most effective in today's digital society.
‘Connecting’ with the Health Libraries Group conference
Authors: Ghumra Imrana
Published: May 2024

Imrana Ghumra, Past Health Libraries Group (HLG) Co‐Chair and now HLG Conference Lead, revisits recent HLG conferences before sharing details of the exciting programme for 2024. Hosted at the Royal College of Physicians, London, 19–21 June 2024, the conference embraces the benefits of a hybrid event, offering both in‐person and online opportunities to networking and to catch up with colleagues from across the country, across sectors and the profession, and embracing ideas and best practice.
Exploring hotness and pungent odour thresholds among three groups of Thai chilli users
Authors: Toontom Nitchara , Meenune Mutita , Aguiar Luis Kluwe , Posri Wilatsana
Published: May 2024

Sensory thresholds of hotness and pungent odour were determined from 120 chilli users. Three groups of Light (L), Moderate (M), and Heavy (H) chilli users were categorised based on their chilli consumption habits and sensitivity to hotness standard solutions. After the screening test, the users participated in 12 Alternative Forced Choice (AFC)‐sets, for each of three stimuli (capsaicin and 1‐Penten‐3‐One (1P3O) odour and dried chilli powder). The dried chilli 3‐AFC sample's concentration range was calculated to equate the same range of standard capsaicin stimuli for hotness sensation measurements. Concentrations of the three stimuli tested were in a range of (0.08–16.80 dry basis g L−1) for standardised dried chilli powder, (0.10–20.16 mg L−1) for capsaicin, and (0.01–2.04 μL L−1) for 1P3O. Heavy chilli users group threshold, as anticipated, indicated the highest average recognition level of stimuli in terms of pungency odour perceived from dried chilli (5.88 g L−1) and 1P3O (1.34 μL L−1), as well as for hotness sensation from dried chilli (7.19 g L−1) and capsaicin (12.79 mg L−1) samples. The magnitudes of heavy user's thresholds were exponentially higher than that of light users. At the recognition thresholds of oral hotness perception, the level of capsaicin presented in dried chilli sample was found to be much lower than the concentration of standard capsaicin sample. It was concluded that pungent odours and other flavours in dried chilli, increase hotness perception as compared with capsaicin stimulus. We also confirmed that 1P3O contributes to chilli pungent odour.
Assessing nutritional probing and storage stability of functional Aloe vera (Aloe barbadensis) based guava jam: a machine learning approach for predictive modelling
Authors: Ibraheem Hafiza Hina , Tariq Muhammad Rizwan , Ali Shinawar Waseem , Umer Zujaja , Basharat Zunaira , Intisar Azeem , Mahmood Tariq , Nayik Gulzar Ahmad , Ramniwas Seema , Alfarraj Saleh , Ansari Mohammad Javed
Published: May 2024

This research aimed to explore the influence of nutritional adjustments and storage stability on a functional, reduced‐calorie guava jam incorporating Aloe vera. Over two months, comprehensive analysis assessed physicochemical properties, sensory traits, microbial stability, and shelf‐life. The addition of Aloe vera gel resulted in significant improvements in pH (3.00 to 3.65), total soluble solids (40.10 to 42.20°Brix), antioxidant activity (36.85% to 81.09%), moisture content (29.48% to 38.82%), water activity (0.78 to 0.84), ash content (0.29% to 0.45%), fat content (0.14% to 0.19%), fibre content (1.05% to 1.86%), and the colour values. Moreover, b* scores for colour indication improved from 15.09 to 18.86. Texture attributes of cohesiveness and firmness improved significantly. Sensory evaluation favoured the T2 variant (20% Aloe vera gel), suggesting it as the optimal formulation. Furthermore, artificial neural networks (ANNs), a technique of machine learning, were utilised to predict guava jam behaviour, with 99% accuracy. The study discovered substantial changes in pH, total soluble solids, antioxidant activity, moisture content, and textural qualities, indicating that Aloe vera supplementation could improve guava jam quality and shelf‐life. The results of ANN predictions about antioxidants and cohesiveness provide information about the product's performance during storage.
Fostering students' AI literacy development through educational games: AI knowledge, affective and cognitive engagement
Authors: Ng Davy Tsz Kit , Xinyu Chen , Leung Jac Ka Lok , Chu Samuel Kai Wah
Published: May 2024

Background

As the significance of artificial intelligence (AI) continues to increase, there is a need for effective scaffolding and support for novice learners. Educators have encountered challenges in effectively scaffolding novice learners AI concepts, and providing appropriate motivational support. Research evidence has shown the potential of game‐based approaches to fostering secondary school students' AI literacy and motivation to learn AI.

Objectives

This study developed an online platform TreasureIsland to gamify ebooks and investigated whether and how students playing with it can effectively enhance their AI literacy. This study aims to contribute an empirical and theoretical basis for AI literacy education and promote the use of gamification that would be broadly applied in other schools.

Methods

A quasi‐experiment was conducted to evaluate the effects of the proposed gamified approach, which included a control group using an ebook with playful resources. To triangulate the quantitative results obtained from the pre and post‐test, focus group interviews were also conducted.

Results

The platform was effective in improving students' motivation, self‐efficacy, career interest, and understanding of AI concepts and ethics, but did not enhance their confidence of using AI, and high cognition of applying, evaluating and creating AI. TreasureIsland players demonstrated significant improvement in all affective and cognitive domains, except for the ability to apply, evaluate, and create AI. Interviews revealed that the gamified approach could promote students' AI literacy by adhering to guidelines, including (1) creating a competitive and motivating learning environment through game mechanics, (2) providing scaffolding modules and feedback, and (3) visualising complex AI concepts via simulations. Feedback collected from the study suggested adding pedagogical elements such as flipped classrooms and project‐based learning in future research to improve the instructional design, and enable students to reach a higher level of cognition.

Conclusions

This study concludes that the use of gamification can provide affective and cognitive support and an enjoyable experience for fostering learners' AI literacy. It helps instructional designers and teachers enrich the pedagogical knowledge related to gamified platform and AI literacy.
Medicines for an aging population: The EMA perspective and policies
Authors: Cerreta Francesca , Iskra Ewa Balkowiec , Cupelli Amelia , Sepodes Bruno , Rönnemaa Elina , Rosa Mário Miguel , Mayrhofer Sabine , Trauffler Martine , Torre Carla , Berntgen Michael , Vucic Katarina , Bahri Priya , Koch Armin , Herdeiro Maria Teresa , Mirošević Skvrce Nikica , Pallos Julia , Laslop Andrea
Published: May 2024

The European Medicines Agency adopted their Geriatric Medicines Strategy more than a decade ago. The strategy aims at elucidating the evidence basis for marketing authorization of new medicines which will be used in the older population, and at ensuring the appropriate communication of findings to the patient and healthcare provider. During the past decade new tools and data sources have emerged to support the strategy goals, and their use should be considered. Possible concrete actions are presented to improve the design of clinical trials, the data collection both pre‐ and post‐approval, the assessment of the findings, and the communication to assist informed prescription and safe medicine taking. Implementation and prioritization of these actions should be done from the perspective of addressing the needs of patients while maximizing efficient use of resources, with the aim of integrating geriatric aspects into routine medicines development and assessment.
Microbial‐ and host immune cell‐derived extracellular vesicles in the pathogenesis and therapy of periodontitis: A narrative review
Authors: Wang Jenny , Liu Chun , Cutler Jason , Ivanovski Sašo , Lee Ryan SB , Han Pingping
Published: May 2024

Periodontitis is a chronic inflammatory disease caused by dysbiotic biofilms and destructive host immune responses. Extracellular vesicles (EVs) are circulating nanoparticles released by microbes and host cells involved in cell‐to‐cell communication, found in body biofluids, such as saliva and gingival crevicular fluid (GCF). EVs are mainly involved in cell‐to‐cell communication, and may hold promise for diagnostic and therapeutic purposes. Periodontal research has examined the potential involvement of bacterial‐ and host‐cell‐derived EVs in disease pathogenesis, diagnosis, and therapy, but data remains scarce on immune cell‐ or microbial‐derived EVs. In this narrative review, we first provide an overview of the role of microbial and host‐derived EVs on disease pathogenesis. Recent studies reveal that Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans‐derived outer membrane vesicles (OMVs) can activate inflammatory cytokine release in host cells, while M1 macrophage EVs may contribute to bone loss. Additionally, we summarised current in vitro and pre‐clinical research on the utilisation of immune cell and microbial‐derived EVs as potential therapeutic tools in the context of periodontal treatment. Studies indicate that EVs from M2 macrophages and dendritic cells promote bone regeneration in animal models. While bacterial EVs remain underexplored for periodontal therapy, preliminary research suggests that P. gingivalis OMVs hold promise as vaccine candidates. Finally, we acknowledge the current limitations present in the field of translating immune cell derived EVs and microbial derived EVs in periodontology. It is concluded that microbial and host immune cell‐derived EVs have a role in periodontitis pathogenesis and hence may be useful for studying disease pathophysiology, and as diagnostic and treatment monitoring biomarkers.