bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychometric Properties of A Silhouette Rating Scale Assessing Current And Ideal Body Size And Body Dissatisfaction In Adults
Authors: Lombardo Caterina , Cerolini Silvia , Esposito Rita Maria , Lucidi Fabio
Published: June 2021

Purpose: The study aims at validating a new pictorial tool, the Silhouette Rating Scale (SRS). It consists of a series of 9 female or male silhouettes. It was created to assess current and ideal body size evaluation, and body dissatisfaction. Our aims were to test the concurrent, convergent and discriminant validity of the scale, evaluating possible gender differences.Method: A first sample of 754 young adults (age M=26.10±8.50, males N=218) and a second sample of 210 young adults (age M=21.19±3.22, males=43) completed the Silhouette Rating Scale, and other self-report measures assessing body size evaluation, disordered eating, body satisfaction, depression, emotion regulation and insomnia. Results: Statistical analyses performed on the first sample largely support the concurrent validity of the scale. Results obtained from the second sample confirm its convergent validity, showing strong correlations with the Contour Drawing Rating Scale. Additionally, the correlations performed between the three responses of the Silhouette Rating Scale and other measures of eating disorders, depression, insomnia and emotion regulation indicated a good discriminant validity, though some of the variables measured seem to be significantly correlated. Conclusions: The Silhouette Rating Scale is a reliable and valid tool for assessing current body size, body ideal and body dissatisfaction as compared as other widely used scales. It guarantees the universality of use thanks to the absence of details related to ethnicity or culture and at the same time, maintaining a right level of realism. Future studies will evaluate test-retest validity and its potential within clinical populations.Leve of Evidence: Level V, descriptive cross-sectional study
Expression Profiling of Tumorigenesis Genes in Patients of Laryngeal Papillomatosis
Authors: Khan Muhammad Yasir , Tahir Tehreem , Khan Saif Ullah , Khan Muhammad Sarwar , Mansoor Qaisar
Published: June 2021

Recurrent Laryngeal papillomatosis (RLP) is a disease of the aero-digestive junction superimposed at the upper respiratory tract. Low risk human papillomavirus type 6 and 11 are infectious agents in RLP. Mainstay of treatment for RLP is CO2 laser vaporization for debulking of papilloma. Understanding of the gene changes at expression level might prove helpful for RLP management. The study was designed to evaluate the changes in tumorigenesis genes in RLP cases to mark the severity and aggression at gene expression level for disease management. Tissue samples and peripheral blood samples were acquired from clinically diagnosed RLP patients of age < 12 years undergoing CO2 laser vaporization. Control samples were taken from the normal thyroid tissue of individuals undergoing thyroidectomy. Relative quantitation of gene expression was done by real time polymerase reaction using cDNA samples. Up regulation of CXCL12/ CXCR4 signaling axis, parallel increase in GLUT-1 and over expression of IGF-I, EGFR and ER-α gene product was observed in RLP. On the other hand HIF-1a levels not discerned elevated along with VEGF, PIK3 and AKT gene expression profile. The expression analysis has provoked the possible strategies which can be planned to treat RLP by adjuvant and tailored medication to reduce multiple surgeries.
Interpreting SAXS Data Recorded On Cellulose Rich Pulps
Authors: Larsson Tomas , Stevanic-Srndo Jasna , Roth Stephan V. , Söderberg Daniel
Published: June 2021

A simulation method was developed for modelling SAXS data recorded on cellulose rich pulps. The modelling method is independent of the establishments of separate form factors and structure factors and was used to model SAXS data recorded on dense samples. An advantage of the modelling method was that it made it possible to connect experimental SAXS data to apparent average sizes of particles and cavities at different sample solid contents. Experimental SAXS data could be modelled as a superposition of a limited number of simulated intensity components and gave results in qualitative agreement with CP/MAS 13C-NMR data recorded on the same samples. For the water swollen samples, results obtained by the SAXS modelling method and results obtained from CP/MAS 13C-NMR measurements, agreed on the ranking of particle sizes in the different samples. The SAXS modelling method is dependent on simulations of autocorrelation functions. The time needed for simulations could be reduced by rescaling of simulated correlation functions, due to their independence of the choice of step size in real space. This way an autocorrelation function simulated for a specific sample could be used to generate SAXS intensity profiles corresponding to all length scales for that sample and used for efficient modelling of the experimental data recorded on that sample.
Unified Performance-Based Design of RC Dual system
Authors: MIBANG DURGA , Choudhury Satyabrata
Published: June 2021

A dual system building is comprised of frames and shear walls. In dual system the shear wall predominantly carries the lateral loads arising out of earthquake or wind. Frame is primarily designed for vertical load along with a fraction of lateral load. The force-based method of design or codal design method can hardly design building for pre-defined target objectives. The alternative method of design is displacement-based design (DBD). Available displacement-based design, like, Direct Displacement-Based design (DDBD) had been applied to dual system. However, DDBD method satisfied only drift criteria and was silent about the performance level. Also, the member sizes had to be obtained through iterations. Unified Performance-Based Design (UPBD) method can accommodate both drift and performance level as target design criteria. In the present study the theoretical background of UPBD method for dual system has been explained and detailed design steps have been highlighted. The method has been validated through several dual system buildings with different target design criteria. Dual system buildings have been designed using UPBD method for target objectives of (i) Immediate Occupancy performance level (PL) with drift 1%, (ii) life Safety PL with drift 2% and, (iii) Collapse Prevention PL with drift 3%. The nonlinear evaluation of the designed buildings shows that in all the cases the target design criteria have been fulfilled. The UPBD method of dual system also gives the member sizes in the beginning of the design and thus avoids iteration in design.
Inner ear biomechanics reveals Late Triassic origin of mammalian endothermy
Authors: Araujo Ricardo , David Romain , Benoit Julien , Jacqueline Lungmus , Spoor Fred , Stoessel Alexander , Barrett Paul , Maisano Jessica , Ekdale Eric , Orliac Maeva , Luo Zhe-Xi , Martinelli Agustin , Hoffman Eva , Sidor Christian , Martins Rui , Angielczyk Kenneth
Published: June 2021

Endothermy (“warm-bloodedness”) underpins the ecological dominance of mammals and birds in diverse environmental settings^1-3. However, it is unclear when this crucial feature emerged during mammalian evolutionary history, as most fossil evidence is ambiguous^4-25. Here, we show that new information on this key evolutionary transition can be obtained from the morphology of the endolymph-filled semicircular ducts of the inner ear that monitor head rotations and are essential for motor coordination, navigation, and spatial awareness^26-31. Increased body temperature during the ectotherm–endotherm transition of mammal ancestors would decrease endolymph viscosity, negatively impacting the biomechanics of the semicircular ducts^32,33, while simultaneously increasing activity levels^34,35 required improved performance^36. Specific morphological changes to the membranous ducts and enclosing bony canals were, therefore, necessary to maintain optimal functionality. We track these morphological changes in 341 vertebrates, including 56 extinct synapsids, and show that canals with relatively thin cross-sections and small radii of curvature are indicative of mammalian endothermy. This inner ear morphotype evolved abruptly ~233 million years ago, during the Late Triassic, in Mammaliamorpha. Our conclusion differs from previous suggestions3-17, and we interpret most stem-mammals as ectotherms. Endothermy as a crucial physiological characteristic joins other distinctive mammalian features that arose during this period of climatic instability^37-39.*Ricardo Araújo and Romain David contributed equally to this work.
Unification of treatments and interventions for tinnitus patients (UNITI): a study protocol for a multi-center randomized clinical trial
Authors: Schoisswohl Stefan , Langguth Berthold , Schecklmann Martin , Boecking Benjamin , Cederroth Christopher , Chalanouli Dimitra , Cima Rilana , Denys Sam , Dettling-Papargyris Juliane , Escalera-Balsera Alba , Espinosa-Sanchez Juan Manuel , Gallego-Martinez Alvara , Giannopoulou Efi , Hidalgo-Lopez Leyre , Hummel Michael , Kikidis Dimitris , Koller Michael , Escámez Jose Antonio López , Marcrum Steven , Markatos Nikolaos , Martin-Lagos Juan , Martinez-Martinez Maria , Martinez-Martinez Marta , Ferron Maria Mata , Mazurek Birgit , Mueller-Locatelli Nicolas , Neff Patrick , Oppel Kevin , Perez-Carpena Patricia , Robles-Bolivar Paula , Rose Matthias , Schiele Tabea , Schiller Axel , Simoes Jorge , Stark Sabine , Staudinger Susanne , Stege Alexandra , Verhaert Nicolas , Schlee Winfried
Published: June 2021

Background
Tinnitus represents a relatively common condition in the global population accompanied by various comorbidities and severe burden in many cases. Nevertheless, there is currently no general treatment or cure, presumable due to the heterogeneity of tinnitus with its wide variety of etiologies and tinnitus phenotypes. Hence, most treatment studies merely demonstrated improvement in a subgroup of tinnitus patients. The majority of studies are characterized by small sample sizes, unstandardized treatments and assessments or applications of intervention targeting only a single organ level. Combinatory treatment approaches, potentially targeting multiple systems as well as treatment personalization might provide remedy and enhance treatment responses. The aim of the present study is to systematically examine established tinnitus therapies both alone and in combination in a large sample of tinnitus patients. Further it wants to provide the basis for personalized treatment approaches by evaluating a specific decision support system developed as part of an EU-funded collaborative project (Unification of treatments and interventions for tinnitus patients; UNITI-project).
Methods/ Study design:
This is a multi-center parallel-arm randomized clinical trial conducted at five different clinical sites over the EU. The effect of four different tinnitus therapy approaches (sound therapy, structured counselling, hearing aids, cognitive behavioral therapy) applied over a time period of 12 weeks as a single or rather a combinatory treatment in a total number of 500 chronic tinnitus patients will be investigated. Assessments and interventions are harmonized over the involved clinical sites. The primary outcome measure focuses on the domain tinnitus distress assessed via the Tinnitus Handicap Inventory.
Discussion
Results and conclusions from the current study might not only provide an essential contribution to combinatory and personalized treatment approaches in tinnitus but could also provide more profound insights in the heterogeneity of tinnitus, representing an important step towards a cure for tinnitus.
Trial registration:
ClinicalTrials.gov: NCT04663828. Registered on 11. December 2020
Optimization of Process Parameters during Hydroforming of Tank Bottom using NSGA-III Algorithm
Authors: Zhang Zaifang , Xu Feng , Sun Xiwu
Published: June 2021

The hydroforming technology can realize overall forming of large storage tank’s bottom, but the quality is affected by many technological parameters. In view of wrinkling and cracking defects of integral storage tank’s bottom in hydroforming, a multi-objective optimization model is established for process parameters include pre-expansion pressure, hydraulic pressure, blank holder force and fillet radius of blank holder. Based on finite element simulation, the surrogate model between process parameters and quality criteria is established using Kriging technique. NSGA-III is used to determine optimal process parameters when storage tank’s bottom reaches targets include minimum wall thickness variations, minimum fracture trend, minimum flange wrinkle and minimum wrinkle trend. Compared with Particle swarm optimization (PSO) algorithm, NSGA-III algorithm is more suitable to solve this optimization problem. The validity of this method and accuracy of the results are verified by simulation experiments.
WITHDRAWN: A multi-level qualitative analysis of sensitive-intervention stunting program: from regulation to action
Authors: Purnama Tri Bayu , Arrazy Syafran , Wangge Grace
Published: June 2021

Objectives : The multisectoral problem of stunting with sensitive interventions is still a public health problem. This problem is due to complex factors that affect stunting programs across sectors to accelerate the stunting program for non-nutrition programs. This study aims to identify challenges in implementing sensitive interventions on stunting from regulation to implementation of activities. Methods : A qualitative multilevel approach was used for this research by conducting in-depth interviews, observation, and document review on the supply and demand aspects of the stunting-sensitive intervention program. The District of Health as the first level in the regulator, the Public health center as the implementer of the activity, and the community as the target of the activity were interviewed about the impact of regional regulatory innovations on stunting prevalence. Results This study explains that the families of stunting infants are not familiar with sensitive intervention activities and are still focused on specific packages. Coordination and collaboration, both intern level and between levels, have not been maximally implemented. The development of innovations in regional regulations has no impact on public health indicators both before and after the design is implemented. Conclusion for practices This research concludes that deploying cadres, transforming regulation inovation to social inovation and program managers trainning are crucial to accelerate sensitive intervention program.
Experimental Evaluation on Components of Shear resistance of Reinforced Concrete Beams with Shear Reinforcement Provided
Authors: Joshi Sreenivasa Prasad , P Poluraju
Published: June 2021

The contribution of aggregate interlocking and dowel force in shear strength of reinforced concrete beams was topic of research for many years. The precise forecasts of shear behavior were challenging to determine due to complication involved. The existing theories had focused on aggregate interlocking force and shear resistance arising due to concrete compression zone, neglecting the contribution of dowel force despite considering as significant constituent in shear transfer mechanism. The present investigation focuses on cogitating all components in shear transfer mechanism by providing shear reinforcement and keeping clear cover and effective span to depth ratio constant. Sixteen specimens were considered for parametric study by employing suitable variables such as increase in strength of concrete and variation in flexural reinforcement. Eight specimens were conventional beams and the remaining eight specimens were provided with preformed cracks. Moment vs. displacement curvature and strain vs. moment curvature were plotted to evaluate shear at uncracked compression zone and accordingly aggregate interlocking force and dowel force were determined based on the empirical formulas proposed. From the result it was confirmed that contribution of aggregate interlocking force and dowel force were insignificant and shear resistance due to uncracked compression zone is the sole contributor in shear transfer mechanism. Structural behavior of concrete beams was also studied and it was confirmed that beams with preformed cracks exhibited better structural behavior when related to conventional beams.
Survey Of Male And Female Frogs (Pyxicephalus Edulis) And Assosciated Toxic And Non Toxic Elements
Authors: Ediagbonya Thompson Faraday , Ogunjobi Adedayo Johnson , Adenikinju Ademola Charles
Published: June 2021

The present research was performed to determine the concentration of heavy metals in the male and female specimens of the identified frog species: pyxicephalus edulis collected from the Igbekebo River in Igbekebo, Ese-odo local government. Adult frogs (male and female) were collected from the river bank, and sediment samples and water samples were also collected at five ( 5) separate locations in the river. The frogs were dried separately at 1050C for 6 hrs and then crushed into small particles (powder form). The sediment samples were air-dried for three days. Elemental components in frog samples and sediment samples were analyzed using Proton Induced X-Ray Emission (PIXE). Physiochemical parameters and heavy metals of the water samples were also analyzed. The findings showed that the concentrations of Si, P, Cl, Ni, Zn and Cd were higher in Male frog while Mg, Al, K, Ca, Ti, V, Cr, Mn, Fe, Co, Cu, Zr, Pb and Sn were higher in female frogs, the explanation for this variability is not known but may be due to variations in the genetic make-up of Male and Female frogs. The concentration of heavy metals in both male and female frogs was substantially higher relative to the available WHO limits. The mean concentration of elemental constituents in sediment was higher than the IAEA limit. The values of enrichment and the Igeo values were very high.
Competitiveness of a Preschool Educational Organization in the Educational Services Market
Authors:   Baranovichi State University, Natalia F. Zakharchenia
Published: June 2021

The choice of educational services and the struggle for the consumer in the field of education is a difficult task for a modern preschool educational organization. The high quality of the provision of educational services does not guarantee its relevance, since it cannot always meet the needs of consumers. The author has assumed that the management of educational services of a preschool educational organization would be effective if carried out on the basis of a marketing approach. The article provides a scientific rationale for the choice of a model of competitiveness of a preschool educational organization, presented in the form of a mathematical expression. The author’s analysis of dissertation research in the field of economic theory made it possible to develop it on the analogy of the author’s model of A. A. Sknarin, but in the education system. To use the modified model in determining the competitiveness of a preschool educational organization, a methodology is proposed, the content is disclosed and a functional description of the model is given. Such a detailed presentation of it opens up prospects for the application of the competitiveness model of a preschool educational organization in practice to test the hypothesis about the factors that affect the increase in competitiveness: external, internal and systemic. Keywords: marketing, preschool educational organization, educational services market, competitiveness
Development of Skills for Analysis of Artwork in Children of Preschool and Primary School Age
Authors:   Transbaikal State University, Alexandra I. Ulzytueva , Alla V. Kurganskaya ,   Transbaikal State University
Published: June 2021

The article updates the problem of developing the skills of analyzing a work of art in children of preschool and primary school age. The article defines the significance of the analysis of works of fiction in solving the problems of introducing children to book culture, forming interest in reading children’s literature. The solution of the indicated problems is possible when teachers of preschool and primary general education have methodological competence, manifested in knowledge of the features of works of folklore and fiction, in the ability to analyze them. In order to identify the formation of methodological competence, teachers of preschool educational organizations and secondary schools were offered questionnaires, the results of the questionnaire are presented in the article. It was revealed that teachers realize the importance of analyzing works of art, know the methods and techniques of analyzing works, explaining words unfamiliar to children, are able to formulate questions that reveal an understanding of the content of the work, etc. However, it is not always correct to determine at what stage of acquaintance with an art work it is appropriate to ask questions of a different nature, focused on a deep analysis of the work. The analysis of teacher questionnaires and the direct monitoring of the educational activities of children and teachers in preschool educational organizations and schools indicate the need for systematic and systematic work to increase the methodological competence of primary school teachers and teachers in the field of analysis of works of art. Keywords: analysis of artistic work, children of preschool and primary school age, methodological competence, methods and techniques of analysis of artistic work, federal state educational standard of preschool education, federal state educational standard of primary general education
Development of Cognitive Activity of Preschool Children: to the Problem Statement
Authors:   Herzen State Pedagogical University of Russia, Olga V. Akulova
Published: June 2021

The article deals with the interpretation of the “cognitive activity” concept. Based on the analysis of classical and modern studies, the author formulates the author’s definition of “cognitive activity of preschool children” as a motivational basis for children’s activities and research behavior; the quality of personality that affects the formation of initiative and independence in various types of activities; the condition for obtaining a higher result of activity and increasing the significance of the process of cognition for the child. The place of cognitive activity in the structure of children’s activities is shown. The system of cognitive activity of a preschooler is represented by two subsystems: the search for information and the use of experience in activities. The idea of the need to integrate the content of the knowledge areas for the initiation of cognitive activity of preschoolers is proved. Two types of cognitive activity of 3–7 years aged children are revealed: independent and initiated by an adult. The levels of preschool children`s cognitive activity are characterized: reproducing, heuristic, creative. The article substantiates the potential of three types variable educational routes technology using (“help”, “support”, “development assistance”) for building targeted support for the cognitive activity of preschool children. Keywords: cognitive activity, levels of cognitive activity, cognitive development, children of preschool age, preschool children activities, educational support, variable educational route
Sustainable business development vision under the covid-19 pandemic
Authors: Antonyuk Nataliya , Plikus Iryna , Jammal Mohammad
Published: June 2021

This article considers the issues of forming sustainable business development strategies in the context of the COVID-19 pandemic. The authors noted that the COVID-19 pandemic significantly affected the business environment, changing each country’s economy’s priorities and principles of functioning. The study’s main goal is to analyze the impact of quarantine measures and the pandemic on sustainable business development. The article examines the positive and negative COVID-19 influence on economic development. The methodological basis of this study is a systematic literature review using international scientific databases. For determining the scientists’ and the business interest in the studied issue, Google Trends and Google Ngram Viewer tools were used. The authors used a systematic approach, abstract-logical and structural-dynamic analysis to determine trends in entrepreneurial activity. This paper presents the findings in shifting prioritize business skills for future development. The obtained results showed that individual professional and personal development became more important compared to communication skills. The authors identified the negative pandemic consequences such as social stratification and significant psycho-emotional pressure affecting socio-economic development. In turn, there is a need to quickly adapt to rapid changes, especially in the professional sphere was emphasized. The authors noted the inevitable digitalization process, which requires psychological readiness, stress resistance, cognitive flexibility, and emotional maturity. The obtained results allowed identifying the priorities of sustainable business development and areas of psychological support for private entrepreneurship in Ukraine. Thus, the formation of strategies for sustainable economic development in Ukraine should be based on business digitalization, adaptation to new business conditions, the acquisition of modern skills, reducing economic stratification of society, and reducing psychological stress. The study findings could be used in devising the regional development strategy to ensure a sustainable and efficient business environment. Moreover, the obtained results could be useful for the entrepreneurs to ensure personal development and get the desired level of profit while minimizing the business risks.
Measuring QCD Splittings with Invertible Networks
Authors: Bieringer Sebastian , Butter Anja , Heimel Theo , Höche Stefan , Köthe Ullrich , Plehn Tilman , Radev Stefan T.
Published: June 2021

QCD splittings are among the most fundamental theory concepts at the LHC. We show how they can be studied systematically with the help of invertible neural networks. These networks work with sub-jet information to extract fundamental parameters from jet samples. Our approach expands the LEP measurements of QCD Casimirs to a systematic test of QCD properties based on low-level jet observables. Starting with an toy example we study the effect of the full shower, hadronization, and detector effects in detail.
Influence of profitability on responsibility accounting disclosure – Empirical study of Vietnamese listed commercial banks
Authors: Quoc Thinh Tran
Published: June 2021

Corporate social responsibility is the development trend in globalization. Businesses need to be accountable to shareholders. An organization should handle the relationship between community, economic, and social factors. The disclosure of responsibility accounting information by businesses has important implications for information users as well as stakeholders. The paper is intended to verify the influence of profitability on the disclosure of responsibility accounting of all listed commercial banks in Vietnam. The paper employs time series data for 2015–2019 and uses the ordinary least square method to test the model. Five independent variables related to profitability are examined. The results of the study show that ROA and ROE have a positive influence on responsibility accounting disclosure. Thereby, the state agencies of Vietnam need to promulgate regulations of responsibility accounting disclosure according to international standards and strictly control the disclosure of Vietnamese commercial banks to improve the quality of the information in the context of international integration.
RESPONSABILIDADE CIVIL DO CONTADOR NA QUALIDADE DE PROFISSIONAL LIBERAL QUE ATUA COMO FORNECEDOR NA RELAÇÃO DE CONSUMO
Authors: Alves Fabricio Germano , Costa Iandeyara Indra Souza
Published: June 2021

O presente trabalho versa acerca do instituto da responsabilização civil. Especificamente sobre a forma de responsabilização do profissional contábil na qualidade de profissional liberal. Nessa perspectiva, muitos são os desafios enfrentados, tendo em vista o desconhecimento das implicações dos dispositivos legais que tratam das relações de consumo por parte da sociedade e, até mesmo, dos profissionais/fornecedores. Por esse fato, é de suma importância estudar o tema, a fim de esclarecer a forma de responsabilização dos contadores quando atuam como fornecedores de uma relação de consumo. Diante disso, busca-se esclarecer como se dá a responsabilização do contador que exerce sua atividade como profissional liberal, entendendo o instituto da responsabilidade civil, as regulamentações específicas da profissão, bem como o posicionamento da jurisprudência pátria sobre o assunto. A metodologia utilizada consistiu na pesquisa básica e qualitativa, com base na análise bibliográfica, legal e jurisprudencial, com o objetivo descritivo e propósito de fornecer uma avaliação de resultados. Conclui-se que o contador, quando na qualidade de profissional liberal em uma relação de consumo, responde subjetivamente pelos seus atos, ou seja, possui responsabilidade pessoal apurada mediante verificação de culpa e, na hipótese de dar causa a um dano ou ameaça de dano, incumbi-lhe o ônus de provar que não agiu com imprudência, negligência ou imperícia.
JUDICIALIZAÇÃO DAS RELAÇÕES SOCIAIS: UMA ANÁLISE DO PROCESSO JUDICIALIZANTE DA LEI MARIA DA PENHA À LUZ DE THEOPHILOS RIFIOTIS
Authors: Paes Galvani Vivian , Graupe Mareli Eliane
Published: June 2021

O presente artigo objetiva refletir acerca dos processos de judicialização das relações sociais, mais especificamente sobre a Lei Maria da Penha, nº 11.340/2006. É importante compreender as origens do fenômeno da judicialização, das violências de gênero e das reivindicações e manifestações da sociedade perante as situações de descaso estatal, em conformidade com a demanda de combate à impunidade. É uma pesquisa de abordagem qualitativa e foi utilizado o método de pesquisa bibliográfico, a partir do estudo do conceito de judicialização, e de pesquisa documental, por meio da análise da Lei Maria da Penha. Os dados apontam que é importante questionar a proliferação da perspectiva primária penalizante e investir nas estratégias e nas ações de prevenção e enfrentamento da violência de gênero.
What does it take for an author to create a fictional object?
Authors: Lins Lemos Italo
Published: June 2021

Neste artigo eu respondo à objeção principal de Stuart Brock (2010, 2016) ao artefactualismo. De acordo com Brock, artefactualistas como Amie Thomasson (1999) não conseguem explicar como e quando os objetos ficcionais são criados, sendo o artefactualismo, portanto, um tipo de criacionismo teológico. Contrariamente a Brock, e adaptando a teoria dos atos de fala de John Austin (1962) ao presente caso, eu argumento que objetos ficcionais são criados através de um proferimento performativo que, para ser feliz, deve (i) ser realizado pelo indivíduo adequado (um autor ou autora), (ii) com as intenções apropriadas (o ato de realização de ficção), no contexto adequado (associado às nossas práticas pré-estabelecidas de ficção) onde o autor ou autora (iv) nomeia, fornece ao menos uma descrição ou oferece uma imagem para instituir o objeto individual através dos seus atos intencionais.
Elogio da razão mundana: Resenha de Elogio de la razón mundana: Antropología y política en Kant, de Nuria Sánchez Madrid
Authors: Nahra Cinara
Published: June 2021

Resenha da obra Elogio de la razón mundana: Antropología y política en Kant, de Nuria Sánchez Madrid (Madrid e Buenos Aires: La Cebra, 2018)
Intelligent centralized traffic management of a rapid transit system under heavy traffic
Authors: Baranov L. A. , Sidorenko V. G. , Balakina E. P. , Loginova L. N.
Published: June 2021

Aim. In today’s major cities, increased utilization and capacity of the rapid transit systems (metro, light rail, commuter trains with stops within the city limits) – under condi[1]tions of positive traffic safety – is achieved through smart automatic train traffic management. The aim of this paper is to choose and substantiate the design principles and architecture of such system.

Methods. Using systems analysis, the design principles and architecture of the system are substantiated. Genetic algorithms allow automating train traffic planning. Methods of the optimal control theory allow managing energy-efficient train movement patterns along open lines, assigning individual station-to-station running times following the principle of mini[1]mal energy consumption, developing energy-efficient target traffic schedules. Methods of the automatic control theory are used for selecting and substantiating the train traffic algorithms at various functional levels, for constructing random disturbance extrapolators that minimize the number of train stops between stations.

Results. Development and substantiation of the design principles and architecture of a centralized intelligent hierarchical system for automatic rapid transit traffic management. The distribution of functions between the hierarchy levels is described, the set of subsystems is shown that implement the purpose of management, i.e., ensuring traffic safety and comfort of passengers. The criteria are defined and substantiated of management quality under compensated and non-compensated disturbances. Traffic management and target scheduling automation algorithms are examined. The application of decision algorithms is demonstrated in the context of uncertainty, use of disturbance prediction and genetic algorithms for the purpose of train traffic planning automation. The design principles of the algorithms of traffic planning and management are shown that ensure reduced traction energy consumption. The efficiency of centralized intelligent rapid transit management system is demonstrated; the fundamental role of the system in the digitalization of the transport system is noted.

Conclusion. The examined design principles and operating algorithms of a centralized intelligent rapid transit management system showed the efficiency of such systems that ensured by the following: increased capacity of the rapid transit system; improved energy efficiency of train traffic planning and management; improved train traffic safety; assurance of operational traffic management during emergencies and major traffic disruptions; improved passenger comfort.
Risk-oriented approach to life cycle contract implementation of weapons and military equipment
Authors: Dubovsky V. А. , Dubovskaya N. I. , Nikolaev А. S.
Published: June 2021

Aim. Today, the development and operation of weapons and military equipment is characterized by fast-growing customer requirements, which, in turn, leads to their increased technical complexity and cost. It is obvious that maintaining the required physical and operational characteristics of high-technology weapons and military equipment by the users is not always possible due to a number of reasons, including insufficient capabilities of the service units that do not have the required personnel, assets and competences. In turn, the manufacturers involved in the delivery of the government defence order are also interested in shaping long-term relations with the customer allowing to build a platform for sound progress. One of the possible solutions for such interaction between the customer and the contractor used worldwide and in Russia is public-private partnership in the form of life cycle contracts. Despite the obvious advantages, its introduction into the practice of weapons and military equipment life cycle is hampered by a number of adverse factors (insufficiencies in the regulatory framework and technical standards, poor level of information technology deployment in LC management) that need to be overcome in terms of both scientific and practical considerations. It is perfectly clear that developing a tool that would allow mitigating a full spectrum of problems as part of this study would be an extremely challenging task. Given the above, the paper aims to examine risks as one of the aspects of this complex problem that implies the development of a new approach to the interaction of the parties involved in a life cycle contract for weapons and military equipment, taking into account the current conditions, interests, goals and objectives. It involves comprehensive analysis of uncertainty and the whole spectrum of possible risks associated with the weapons and military equipment life cycle processes.

Methods. The managerial decision-making is based on the decision tree method that allows dividing the complex decision-making problem into component tasks and obtaining quantitative risk estimates, thus developing an adequate system of measures for the prevention of event risks and reduction of their negative consequences.

Results. Based on the proposed methodological framework, a risk management algorithm has been developed, a matrix has been defined for assessing risks and their impact on the temporal and technical characteristics, as well as the costs of a project.

Conclusion. The suggested approach is universally applicable and can be used by both the officials of military authorities in the process of scientific support of LCC implementation, and by the management of defense contractors as they develop their interaction with the military authorities responsible for the creation and operation of weapons and military equipment.
Specificity of the development of the damage process to network structures of pipeline transportation systems
Authors: Tararychkin I. A.
Published: June 2021

Introduction.Industrial pipeline transportation systems are complex, potentially hazardous engineering facilities that ensure the delivery of specified amounts of a target product to consumers. The development of emergencies associated with the transition to the down state of a certain number of pipelines may result in the disconnection of some or all the product consumers from the source. If the system’s linear elements transition to the down state in a random order, such a change of the network structure is called a progressive damage. A progressive damage is especially hazardous if, in the course of maintenance activities, a part of the system or a set of process pipelines is disconnected.

The Aimof the work is to identify the change patterns of pipeline system resilience when affected by progressive damage and to develop practical recommendations for ensuring the resilience of such systems in operation and during maintenance operations.

Methods of research.The resilience of systems as the capability to resist progressive damage was evaluated with an indicator that represents the average fraction of pipelines whose transition into the down state causes the disconnection of all consumers from the source of the product. The resilience values were defined by means of computer simulation. The network structure and the nature of the existing intersystem communications were defined using an adjacency matrix.

Results.Damage to a transportation network structure is regarded as a result of a two-stage process. At the stage of target transformation, linear elements are purposefully excluded from a full graph-based structure, bringing the network to a certain initial state. At the second stage, the original structure is transformed according to the mechanism of progressive damage. Such approach allows correctly assessing the changes in the resilience of complex network structures and their ability to resist the development of the processes of damage. The paper sets forth calculated characteristics that allow predicting the behaviour of pipeline networks affected by emergencies. The existence of limit network structures is demonstrated that prove to be very vulnerable to the development of progressive damage.

Conclusions. As the process of targeted transformation goes on, the ability of newly formed network structures to resist the development of progressive damage progressively diminishes. The lowest level of pipeline system resilience against the development of the process of progressive damage can be observed as the structure of the network nears the limit state. When preparing maintenance activities with scheduled exclusion of a number of linear elements from an active pipeline system, the proximity of the newly built network structure to the limit state should be assessed along with the resilience of the restored system to possible development of progressive damage.
Role of ZEB Family Members in Proliferation, Metastasis, and Chemoresistance of Prostate Cancer Cells: Revealing Signaling Networks
Authors: soleymani Leyla , Zarrabi Ali , Hashemi Farid , Hashemi Fardin , Zabolian Amirhossein , Banihashemi Seyed Mohammad , Moghadam Shirin Sabouhi , Hushmandi Kiavash , Samarghandian Saeed , Ashrafizadeh Milad , Khan Haroon
Published: June 2021

Prostate cancer (PCa) is one of the leading causes of death worldwide. A variety of
strategies, including surgery, chemotherapy, radiotherapy, and immunotherapy, are applied for PCa
treatment. PCa cells are responsive towards therapy at early stages, but they can obtain resistance
in the advanced stage. Furthermore, their migratory ability is high in advanced stages. It seems that
genetic and epigenetic factors play an important role in this case. Zinc finger E-box-binding homeobox
(ZEB) is a family of transcription with two key members, including ZEB1 and ZEB2. ZEB
family members are known due to their involvement in promoting cancer metastasis via EMT induction.
Recent studies have shown their role in cancer proliferation and inducing therapy resistance.
In the current review, we focus on revealing the role of ZEB1 and ZEB2 in PCa. ZEB family
members are able to significantly promote the proliferation and viability of cancer cells. ZEB1 and
ZEB2 enhance migration and invasion of PCa cells via EMT induction. Overexpression of ZEB1
and ZEB2 is associated with a poor prognosis of PCa. ZEB1 and ZEB2 upregulation occurs during
PCa progression and can provide therapy resistance to cancer cells. PRMT1, Smad2, and non-coding
RNAs can function as upstream mediators of the ZEB family. Besides, Bax, Bcl-2, MRP1, Ncadherin,
and E-cadherin can be considered as downstream targets of the ZEB family in PCa.
Anemia and Low Birth Weight Risk After Fe Therapy in Pregnancy, Puskesmas Kecamatan Kebayoran Baru
Authors:   Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang, Sudarmaningsih Dyah Ponco , Hikmah Febrial , Widada N Sri , Ariningpraja Rustiana Tasya
Published: June 2021

Physiological changes in pregnant women have an impact on reducing the hemoglobin (Hb) level so that they can experience anemia. Anemia in pregnant women is still a high case and be one of the factors of low birth weight (LBW). Iron (Fe) is consumed routinely is thought to help reduce the risk of anemia, but it's still not known yet between the relation of Fe consumed to LBW incidents. Data were taken by cross sectional as many as 150 samples of pregnant women. The results obtained that 56% of pregnant women had anemia. After Fe therapy doses 60-120 mg/day, Hb levels increased by 0.3 g/dL. Although there were significant differences before and after Fe therapy in pregnant women with anemia, about 74% of pregnant women still had experience anemia despite Fe therapy. Provision of Fe therapy for pregnant women either with a dose of 60-120 mg/day, had not been effective enough in increasing Hb levels. LBW cases were also found in this study, which is around 9.3%. Pregnant women with anemia have a higher risk of LBW. This indicates that offering Fe to pregnant women has not been effective.
Nursing Students Readiness Through Clinical Learning
Authors: Sianturi Sondang Ratnauli , Natalia Lia
Published: June 2021

Studentsâ€™ experiences in doing clinical learning are a challenge in themselves where studnets interact directly with patients and face the changes that occur. Students are prepared in various aspects to deal with learning in clinics where students contact with patients. The phenomenon that occurs is students are not confident to practice and learn cases in clinic, fear of the tasks and responsibilities given. The purpose of this study is to describe of nursing student readiness when practice in clinical setting at the Nursing Institution in Jakarta. This research method is a quantitative method with a correlative design with 219 samples (nursing students). The measuring instrument used in this study is by using the CLES questionnaire, motivation and anxiety faced by students. The results showed that the RMSEA value is 0.000, which means that the fit of the model is good or good fit and 90% internal confidence, and there is an influence from the environment (p value 0,000), motivation (p value 0,000) and anxiety factors (p value 0,000) to the readiness students doing clinical learning. Therefore, to get good service quality in nursing education, collaboration between health care and education is very important to create a conducive environment for students to conduct clinical learning.
Literature Review: Adolescent Perceptions Toward Teenage Pregnancy
Authors: Amalia Delia , Ermiati Ermiati , Sari Eka Afrima
Published: June 2021

Teenage pregnancy is one of the health problems in developing countries that has not been resolving yet. Adolescent perception is one of the factors that influence the incident of teenage pregnancy. At present, there are still limited research articles about adolescent perceptions toward teenage pregnancy. The purpose of this literature study is to find out how adolescent perceptions toward teenage pregnancy. This literature study used a scoping review method. There were 6 articles was analyzed after sorting by inclusion criteria consisting of the article contained an explanation or description of adolescent perceptions of teenage pregnancy, the year 2015-2020, English or Indonesian, full text, samples aged 10-19 years. The result of the study found out that adolescents had negative perceptions such as pregnancy among adolescents is too young, teenage pregnancy caused by several factors, and has various negative impacts toward adolescents, parents, and infants. Furthermore, adolescents had positive perceptions such as teenage pregnancy in adolescent is normal, life will not differ, her boyfriend will be responsible to her pregnancy. The conclusions from this literature review were the difference in perceptions between adolescents towards pregnancy in adolescents is influenced by adolescent environmental culture and believed.
Overview of The Needs of Sustainable Professional Development For Alumni Ners Faculty of Nursing University of Riau
Authors: Fitriana Fitriana , Amir Yufitriana , Erwin Erwin
Published: June 2021

Continuing professional development is a process that must be carried out by each individual nurse in order to maintain and update the development of health services through setting high standards of professional practice. The purpose of this research was to determine the need for ongoing professional development activities which include training, seminars, workshops, and formal education for alumni of the Faculty of Nursing, Riau University. Design was descriptive quantitative. The research sample was 293 respondents taken using purposive sampling technique. The results showed the need for continuous professional development in the first priority is training (34.8%) with the type of training needed is emergency nursing training or BTCLS (19.8%), and the second highest priority is formal education (25.3%), who continued S2 if given the opportunity (89.4%) of respondents with the desired form of specialist programs namely management nursing (20.5%) and (10, 6%) want to continue with S3 if given the opportunity. The conclusion of this research is the need for continuing professional development especially training and education activities is very important for Nursing alumni of the Faculty of Nursing, University of Riau to improve their professionalism.Â