bluuebunny/crossref_metadata_2025 huggingface dataset:
Creating a Vocabulary About School-Age Childcare Using Photography
Authors: Bell Kevin , Cartmel Jennifer
Published: February 2019

Engaging children in school-age childcare (SAC) in the research process through the use of photography gives them a voice that is not necessarily heard otherwise. This article discusses a research project undertaken in an Australian SAC service using photography as a means for the children to describe their play experiences. It examines the literature about researching with children using photography and discusses some of the challenges and how these can be overcome in order to provide staff and policy makers in school-age care with understandings about school-age care from the perspectives of the children. SAC plays a significant role in the lives of children and families; however, the research about this service is minimal.
Impact of a Patient Experience Leadership Structure on Performance and Engagement
Authors: Gierlinger Sven , Barden Agnes , Giammarinaro Nicole
Published: February 2019

The patient experience leadership structure at Northwell Health is strategically championed by Culture Leaders, a novel role established to transform the organizational culture from “service excellence” to “patient experience.” This case report describes how the implementation of Culture Leader structure has aided in the improvement of organizational patient experience performance as well as how Culture Leaders remain highly engaged. Responsible for effectuating change by bridging the gap between local and organizational experience strategies, Culture Leader engages key stakeholders within the strategic pillars of culture, care delivery, hospitality, and accountability.
Phase 2 study of clarithromycin, pomalidomide, and dexamethasone in relapsed or refractory multiple myeloma
Authors: Mark Tomer M. , Forsberg Peter A. , Rossi Adriana C. , Pearse Roger N. , Pekle Karen A. , Perry Arthur , Boyer Angelique , Tegnestam Linda , Jayabalan David , Coleman Morton , Niesvizky Ruben
Published: February 2019

The addition of clarithromycin enhances the efficacy of lenalidomide plus dexamethasone in treatment-naive multiple myeloma (MM). We conducted a phase 2 trial to evaluate the safety and efficacy of clarithromycin, pomalidomide, and dexamethasone (ClaPd) in relapsed or refractory multiple myeloma (RRMM) with prior lenalidomide exposure. One hundred twenty patients with a median of 5 prior lines of therapy received clarithromycin 500 mg orally twice daily, pomalidomide 4 mg orally on days 1 to 21, and dexamethasone 40 mg orally on days 1, 8, 15, and 22 of a 28-day cycle. The overall response rate (ORR) was 60% with 23% achieving at least a very good partial response. There was no statistical difference in response rates for patients who were refractory to lenalidomide (ORR, 58%), bortezomib (ORR, 55%), or both lenalidomide and bortezomib (ORR, 54%). Median progression-free survival (PFS) for the cohort was 7.7 months and median overall survival (OS) was 19.2 months. A history of dual-refractoriness to lenalidomide and bortezomib did not significantly impact either PFS or OS. The most common toxicities were neutropenia (83%), lymphopenia (74%), and thrombocytopenia (71%). The most common grade ≥3 toxicities included neutropenia (58%), thrombocytopenia (31%), and anemia (28%). ClaPd is an effective combination in RRMM with response and survival outcomes that are independent of lenalidomide- or bortezomib-refractory status. Toxicities are manageable with low rates of nonhematologic or high-grade events. ClaPd is a convenient, all-oral option in RRMM with comparable efficacy to other highly active, 3-drug, pomalidomide-based combinations. This trial was registered at www.clinicaltrials.gov as #NCT01159574.
Does device matter for inhaled therapies in advanced chronic obstructive pulmonary disease (COPD)? A comparative trial of two devices
Authors: Mannan Haider , Foo Soo Wei , Cochrane Belinda
Published: February 2019

Objective

COPD patients have challenges for effective use of inhalers due to advanced age, fixed airflow obstruction and comorbid medical conditions. Published clinical trials investigate drug efficacy but rarely consider the inhaler device. This trial investigates device efficacy, comparing clinical outcomes for the same medication via two different devices. Our intention was to communicate the results and to critically appraise the study protocol to inform planning of future device comparison research. Subjects with spirometry confirming at least moderate COPD were randomly assigned to inhaler sequence; starting with Accuhaler or metered dose inhaler and spacer (MDI/s). After baseline testing, subjects were assigned to fluticasone propionate/salmeterol xinafoate (SFC) 500/50 mcg twice daily via the first device for 6 weeks’ duration, then changed to the alternate device for the following 6 weeks. Subjects were reassessed in terms of health-related quality of life (HRQL), exercise endurance and lung function after each exposure period.

Results

The recruitment target was not achieved due to unanticipated developments within the pharmaceutical industry, potentially compromising the study’s power. Study outcomes did not differ significantly according to the allocated inhaler device even after adjusting for baseline lung function or inhaler technique. Recommendations for future device comparison protocols are offered.

Trial registration Australia and New Zealand Clinical Trials Registry, Current Controlled Trials ACTRN12618000075280, date of registration: 18.01.2018. Retrospectively registered
Using Anchoring Vignettes to Reevaluate the Link between Self-Rated Health Status and Political Behavior
Authors: Pacheco Julianna
Published: February 2019

Context: The majority of studies linking health to political behavior capture an individual's health with an ordinal survey question, called self-rated health status (SRHS), that asks respondents to rate their health along a five-point scale (e.g., excellent to poor). While studies generally have found associations between SRHS and political behavior, differences in respondent understanding and interpretation of the SRHS question and response categories may lead to biased inferences and invalid analyses.

Methods: The author used anchoring vignettes to evaluate previous inferences regarding SRHS and political behavior, including voter turnout, political participation, and party identification.

Findings: Individuals who participate in politics are more health optimistic than those who rarely participate. Liberals tend to be less health optimistic compared to moderates. Once the SRHS measure is adjusted for interpersonal incomparability, it is no longer associated with voter turnout or party identification.

Conclusions: Researchers should note that adjusting for interpersonal incomparability in the SRHS measure influences our conclusions about health and political behavior. Scholars of political behavior must continue to think conceptually about what we mean by health, as well as critically about how to measure this concept accurately.
The implications of time on the ground on running economy: less is not always better
Authors: Lussiana Thibault , Patoz Aurélien , Gindre Cyrille , Mourot Laurent , Hébert-Losier Kim
Published: February 2019

A lower duty factor (DF) reflects a greater relative contribution of leg swing to ground contact time during the running step. Increasing time on the ground has been reported in the scientific literature to both increase and decrease the energy cost (EC) of running, with DF reported to be highly variable in runners. As increasing running speed aligns running kinematics more closely with spring-mass model behaviors and re-use of elastic energy, we compared the centre of mass (COM) displacement and EC between runners with a low (DFlow) and high (DFhigh) duty factor at typical endurance running speeds. Forty well-trained runners were divided in two groups based on their mean DF measured across a range of speeds. EC was measured from 4-min treadmill runs at 10, 12, and 14 km·h−1 using indirect calorimetry. Temporal characteristics and COM displacement data of the running step were recorded from 30-s treadmill runs at 10, 12, 14, 16, and 18 km·h−1. Across speeds, DFlow exhibited more symmetrical patterns between braking and propulsion phases in terms of time and vertical COM displacement than DFhigh. DFhigh limited global vertical COM displacements in favor of horizontal progression during ground contact. Despite these running kinematics differences, no significant difference in EC was observed between groups. Therefore, both DF strategies seem energetically efficient at endurance running speeds.
Energetics of migratory bats during stopover: a test of the torpor-assisted migration hypothesis
Authors: Baloun Dylan E. , Guglielmo Christopher G.
Published: February 2019

The torpor-assisted migration hypothesis posits that migration is facilitated in bats by the use of torpor during stopover roosting periods, and predicts that at stopover bats regulate time in torpor facultatively so that daily energy expenditure is independent of ambient roosting temperature. Energy savings can thus be directed to migratory movement. However, direct measurements of total roosting energy expenditure in relation to ambient and body temperature are lacking. We captured migratory silver-haired bats (Lasionycteris noctivagans; ∼11g) at Long Point, Ontario, Canada in spring and fall 2016. We used quantitative magnetic resonance analysis to measure body composition change and energy expenditure over a twelve-hour roosting period in a ventilated incubator at 10, 17 and 25°C. We assessed the effects of season, body mass, sex and age on energy expenditure. We found that daily energy expenditure was independent of roosting temperature, and that this was achieved by flexible use of torpor. Variation in body mass at capture was driven mainly by differences in fat, and the amount of body fat was negatively related to torpor use, particularly in spring. Season, sex and age also affected torpor use and energy expenditure, notably with pregnant females being generally fatter and using less torpor than males in spring. We estimate that stopover contributes only 15-20% to the total energy costs of migration in bats compared to 70% or more in typical birds. This study provides support for the torpor-assisted migration hypothesis, and furthers our understanding of the energy budgets of migratory bats.
Does the left aorta provide proton-rich blood to the gut when crocodilians digest a meal?
Authors: Conner Justin L. , Crossley Janna L. , Elsey Ruth , Nelson Derek , Wang Tobias , Crossley Dane A.
Published: February 2019

Reptiles have the capacity to differentially perfuse the systemic and pulmonary vascular circuits via autonomic regulation of the heart and the vascular trees. While this aptitude is widely recognized, the role of “shunting” as a homeostatic mechanism to match convective transport with tissue demand remains unknown. In crocodilians, it has been hypothesized that a pulmonary vascular bypass of systemic venous blood, a right-to-left shunt (R-L), serves to deliver CO2-rich blood with protons needed for gastric acid secretion during digestion. This hypothesis is partially based on the unique crocodilian vascular anatomy where a left aorta (LAo) arises from the right ventricle, and appears to preferentially supply the gastrointestinal system, whereas the right aorta emerges from the left ventricle. Recent theoretical considerations imply that a R-L shunt has minuscule effects on PCO2 (Malte et al., 2017), but direct measurements of blood gases in both the right and left aortae or both the right and left atria in fed animals have not been conducted. For this reason, we measured blood parameters including PO2, PCO2, pHe, [HCO3−] in both aortae (right and left) as well as both atria following ingestion of a gavage feed standardized meal (5% body mass). Blood samples were withdrawn at 3, 6, 12, 24, 36 and 48h into the digestive period to encompass the period of maximal gastric acid secretion. At no point did PCO2 or pH differ between the left and right aortae, whereas PO2 was significantly lower in the left aorta at several time points during digestion. Our findings do not support the hypothesis that a R-L shunt serves to deliver CO2 for the gastrointestinal system after feeding in crocodilians.
Predicting Energy Expenditure of an Acute Resistance Exercise Bout in Men and Women
Authors: LYTLE JASON ROBERT , KRAVITS DANIELLE M. , MARTIN STEVEN E. , GREEN JOHN S. , CROUSE STEPHEN F. , LAMBERT BRAD S.
Published: February 2019

The energy expenditure of resistance exercise (RE) is an important consideration for exercise prescription and weight management, yet prediction models are lacking.

Purpose

This study aimed to develop regression equations to predict energy expenditure (kcal) for RE involving each major muscle group using commonly measured demographic and exercise variables as predictors.

Methods

Fifty-two healthy, active subjects (27 men, 25 women, age 20–58 yr, height 174.1 ± 10.5 cm, weight 188.7 ± 42.6 kg, V˙O2max 36.8 ± 9.2 mL·kg−1⋅min−1) were strength tested to estimate their one-repetition maximum 1 wk before their experimental RE bout. The experimental RE bout consisted of a warm-up set followed by 2–3 sets (2-min turnover) of 8–12 reps at 60%–70% of predicted one-repetition maximum for leg press, chest press, leg curl, lat pull, leg extension, triceps push down, and biceps curl. Kilocalories were estimated from V˙O2 measured continuously throughout the RE bout via an automated metabolic cart. Total exercise volume (TV) was calculated as sets × reps × weight lifted. Multiple linear regression (stepwise removal) was used to determine the best model (highest adjusted R
2) to predict the kilocalorie consumption of the total workout and of the individual RE lifts.

Results

The derived regression equation for the net kilocalorie consumption of an RE bout was as follows: total net kilocalorie = 0.874 (height, cm) − 0.596 (age, yr) − 1.016 (fat mass, kg) + 1.638 (lean mass, kg) + 2.461 (TV × 10−3) − 110.742 (R
2 = 0.773, SEE = 28.5 kcal). Significant equations were also derived for individual lifts (R
2 = 0.62 to 0.83).

Conclusions

Net energy expenditure for a total RE bout and for individual RE can be reasonably estimated in adult men and women using commonly measured demographic and RE variables.
Luminescent peptide tagging enables efficient screening for CRISPR-mediated knock-in in human induced pluripotent stem cells
Authors: Madsen Ralitsa R. , Semple Robert K.
Published: February 2019

Human pluripotent stem cells are increasingly used for CRISPR-mediated gene targeting in efforts to generate models of human diseases. This is a challenging task because of the high sensitivity of these cells to suboptimal conditions, including CRISPR-associated DNA damage and subsequent rounds of single-cell cloning. We sought to develop a sensitive method that enables rapid screening of CRISPR targeted cells, while preserving cell viability and eliminating the need for expensive sequencing of a large number of clones. A protocol was designed in which the luminescent peptide tag, HiBiT, is appended to the extracellular portion of an inert surface membrane protein (CD46), using synthetic CRISPR reagents and a widely distributed human induced pluripotent stem cell (iPSC) line. We find that this approach substantially reduces labour-intensive screening of CRISPR-targeted iPSCs and minimises the number of subcloning steps. Successfully edited iPSCs could be identified within a week of targeting, based only on extracellular luminescence detection in live cells. The total screening time in each round was less than 30 minutes and no sequencing was required. This method can be developed further to serve as a highly sensitive co-selection strategy in CRISPR knock-in experiments, particularly in the context of challenging cell lines.
Methodical Features of the Analysis of Personnel Potential with the Professional Industry Identification of Employees
Authors: Выборова Е. , Vyborova E. , Шатохин А. , Shatohin A.
Published: February 2019

The article considers the method of analysis of personnel potential with the estimation of the level of professional industrial identifi cation on the basis of the management function, which provides defi nition of type of employees taking the moral and psychological state, the career self-realization, the professional industry identifi cation. The article gives a sequence of technique, the peculiarities of its carrying out.
Profesor Witold Mańczak – dydaktyk
Authors: Bochnakowa Anna
Published: February 2019

This memoir on Professor Witold Mańczak as an academic teacher opens with a list of grammars and textbooks of the history of Romance languages which he wrote for students of Romance philology. This is followed by a description of Professor’s lectures in historical grammar of Romance languages – erudite but clear, with multiple examples and digressions which widened the scrutinized topic. Also his manner of examining is mentioned, known and strictly defined criteria of evaluation, and its objectivity. Professor’s colleagues from the Institute of Romance Philology like to reminisce his friendly and selfless help and cordiality towards students – beside his attributed severity. Lastly, we emphasize the importance of Professor’s scientific views and methodology in the shaping of academic staff.
When Anomalies Are Publicized Broadly, Do Institutions Trade Accordingly?
Authors: Calluzzo Paul , Moneta Fabio , Topaloglu Selim
Published: February 2019

This paper studies whether institutional investors trade on 14 well documented stock market anomalies. We show that there is an increase in anomaly-based trading when information about the anomalies is readily available through academic publications and the release of necessary accounting data. This finding is more pronounced among hedge funds and institutions with high turnover, that is, the subset of investors who likely have the abilities and incentives to act on the anomalies. We directly relate the increase in trading to the observed decay in post-publication anomaly returns. Our results support the role of institutional investors in the arbitrage process and in improving market efficiency.

This paper was accepted by Renée Adams, finance.
Urostomy: the poor relation?
Authors: Jury Rachel , Biddle Richard , McGrath John
Published: February 2019

Patient advocate Rachel Jury, Colostomy UK's Richard Biddle and researcher John McGrath introduce the results of a preliminary study on how much health professionals know about caring for urostomates
A nationwide survey of reprocessing, facilities and nursing personnel in Italian endoscopy units
Authors: Guarini Alessandra , Rossetti Elena , Simonelli Pierangelo , Iannone Teresa , Carretto Daniela , Giaquinto Antonella , Iori Giorgio , Valdinoci Monia , Rivara Cinzia
Published: February 2019

Background:

In endoscopy, dedicated nursing roles have developed with the growing availability of sophisticated procedures for diagnosis and therapy in gastrointestinal conditions. Endoscopy centres must maintain high standards in terms of facilities, education and staffing to ensure the safety and quality of patient care.

Aim:

Italy's National Association of Endoscopic Technical Operators-National Association of Gastroenterology and Associated Nurses (ANOTE-ANIGEA) conducted a nationwide survey to assess whether these standards were being met in centres across the regions.

Method:

A specific questionnaire was prepared and distributed to ANOTE-ANIGEA associates, and data were statistically analysed by using chi-square test or Fisher's test, as appropriate.

Results:

A total of 176 endoscopy units were surveyed. A recovery room and a distinct dirty-clean area were lacking in 15% and 45% of centres respectively. In 19% of centres, reusable devices were reprocessed with high-level disinfection rather than sterilisation, while reprocessing was not traceable in 23% of centres. The different centres employed a median of six endoscopy nurses, while in a third of centres only one nurse was employed per endoscopy room. In as many as 56% of centres, reprocessing was carried out exclusively by nurses, as no other trained staff were available. Significant differences emerged when comparing data of centres from northern, central and southern Italy, with centres in the south more likely not to meet expected standards.

Conclusions:

Particular concerns were found regarding reprocessing, especially the lack of a distinct ‘dirty–clean’ route and/or dedicated reprocessing staff in several centres.
The rationale for making a short DVD in relation to the last offices procedure
Authors: Jones Bridie , Parry Maria
Published: February 2019

Background:

This article outlines the rationale of developing a DVD using a simulated patient to show students how to perform the last offices in the UK and what they can expect when a patient dies.

Aim:

This is an aspect of the curriculum that students felt was not adequately covered and they were anxious about experiencing the death of a patient for the first time. The DVD allowed a large number of students to receive extra teaching on this topic and was a time-effective way of introducing more teaching into the curriculum.

Conclusion:

Students felt more prepared for the death of a patient during their first clinical placement.
New records of true bugs (Heteroptera) from Khakasia
Authors: Kuzhuget S. V.
Published: February 2019

The paper contains data of 15 species of heteropterous insects from 8 families for the first time found for Khakassia.
Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis
Authors: Lasher Denise , Szabó András , Masamune Atsushi , Chen Jian-Min , Xiao Xunjun , Whitcomb David C. , Barmada M. Michael , Ewers Maren , Ruffert Claudia , Paliwal Sumit , Issarapu Prachand , Bhaskar Seema , Mani K. Radha , Chandak Giriraj R. , Laumen Helmut , Masson Emmanuelle , Kume Kiyoshi , Hamada Shin , Nakano Eriko , Seltsam Katharina , Bugert Peter , Müller Thomas , Groneberg David A. , Shimosegawa Tooru , Rosendahl Jonas , Férec Claude , Lowe Mark E. , Witt Heiko , Sahin-Tóth Miklós
Published: February 2019

OBJECTIVES:

Premature activation of the digestive protease trypsin within the pancreatic parenchyma is a critical factor in the pathogenesis of pancreatitis. Alterations in genes that affect intrapancreatic trypsin activity are associated with chronic pancreatitis (CP). Recently, carboxyl ester lipase emerged as a trypsin-independent risk gene. Here, we evaluated pancreatic lipase (PNLIP) as a potential novel susceptibility gene for CP.

METHODS:

We analyzed all 13 PNLIP exons in 429 nonalcoholic patients with CP and 600 control subjects from Germany, in 632 patients and 957 controls from France, and in 223 patients and 1,070 controls from Japan by DNA sequencing. Additionally, we analyzed selected exons in further 545 patients with CP and 1,849 controls originating from Germany, United States, and India. We assessed the cellular secretion, lipase activity, and proteolytic stability of recombinant PNLIP variants.

RESULTS:

In the German discovery cohort, 8/429 (1.9%) patients and 2/600 (0.3%) controls carried a PNLIP missense variant (P = 0.02, odds ratio [OR] = 5.7, 95% confidence interval [CI] = 1.1–38.9). Variants detected in patients were prone to proteolytic degradation by trypsin and chymotrypsin. In the French replication cohort, protease-sensitive variants were also enriched in patients with early-onset CP (5/632 [0.8%]) vs controls (1/957 [0.1%]) (P = 0.04, OR = 7.6, 95% CI = 0.9–172.9). In contrast, we detected no protease-sensitive variants in the non-European populations. In the combined European data, protease-sensitive variants were found in 13/1,163 cases (1.1%) and in 3/3,000 controls (0.1%) (OR = 11.3, 95% CI = 3.0–49.9, P < 0.0001).

CONCLUSIONS:

Our data indicate that protease-sensitive PNLIP variants are novel genetic risk factors for the development of CP.
Participation and Ease of Use in Colorectal Cancer Screening: A Comparison of 2 Fecal Immunochemical Tests
Authors: de Klerk Clasine M. , Wieten Els , van der Steen Annemieke , Ramakers Christian R. , Kuipers Ernst J. , Hansen Bettina E. , Lansdorp-Vogelaar Iris , Bossuyt Patrick M. , Spaander Manon C.W. , Dekker Evelien
Published: February 2019

INTRODUCTION:

The impact of fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening on disease incidence and mortality is affected by participation, which might be influenced by ease of use of the FIT. We compared the participation rates and ease of use of 2 different FITs in a CRC screening program.

METHODS:

There were two study designs within the Dutch CRC screening program. In a paired cohort study, all invitees received 2 FITs (OC-Sensor, Eiken, Japan, and FOB-Gold, Sentinel, Italy) and were asked to sample both from the same stool. Ease of use of both FITs was evaluated by a questionnaire. In a randomized controlled trial, invitees were randomly allocated to receive one of the 2 FITs to compare participation and analyzability.

RESULTS:

Of 42,179 invitees in the paired cohort study, 21,078 (50%) completed 2 tests and 20,727 (98%) returned the questionnaire. FOB-Gold was reported significantly easier to use. More participants preferred FOB-Gold (36%) than OC-Sensor (5%), yet most had no preference (59%; P < 0.001). In the randomized trial, 936 of 1,923 invitees (48.7%) returned the FOB-Gold and 940 of 1,923 invitees (48.9%) returned the OC-Sensor, a difference of −0.2% (confidence interval, −3.4% to 3.0%), well within the pre-specified 5% noninferiority margin (P = 0.001). Only one FOB-Gold (0.1%) and 4 OC-Sensors (0.4%) were not analyzable (P = 0.18).

CONCLUSIONS:

Although FOB-Gold was significantly but marginally considered easier to use than OC-Sensor, the number of analyzable tests and the participation rates in organized CRC screening are not affected when either of the FITs is implemented as a primary screening test.
Dampak iklim organisasi terhadap prestasi kerja karyawan dan kepuasan mahasiswa pada Universitas Dr. Soetomo Surabaya
Authors: Baruno Agustiawan Djoko , Sudiro Djoko
Published: February 2019

The purpose of this research is (1) To test and analyze the magnitude of organizational climate impact on employee performance in Dr. Soetomo University Surabaya; (2) To test and analyze the magnitude of the impact of employee performance on student satisfaction at Dr. Soetomo UniversitySurabaya; (3) To examine and analyze the indirect effect of organizational climate on student satisfaction at Dr. Soetomo University Surabaya. This research uses a quantitative approach. The population in this study is all employees and active students of Dr. Soetomo University in even semester Academic Year 2016/2017 from 8 faculties. The taken sample in the research are 100 people from 8 faculties with Proportionate Stratified Random Sampling. The results of this study indicate that (1) Organizational Climate effect on Employee Work Achievement at Dr. University. Soetomo Surabaya, (2) Employee Work Achievement Influence on Student Satisfaction at Dr. Soetomo University Surabaya, (3) Organizational Climate Indirectly Affects Student Satisfaction at Dr. Soetomo University Surabaya. It is expected that the results of the study can provide information and evaluation for the marketing and human resources management department of the Dr. Soetomo university Surabaya.
Analisis Pengaruh Pengungkapan Sustainability Report, Kinerja Keuangan, Kinerja Lingkungan Terhadap Nilai Perusahaan
Authors: Sawitri Aristha Purwanthari , Setiawan Nurcholis
Published: February 2019

Tujuan peneliitian ini yaitu untuk melihat pengaruh dari pengungkapan sustainability report, kinerja keuangan dan kinerja lingkungan terhadap nilai perusahaan. Sampel penelitian ini adalah perusahaan yang masuk dalam index 30 pada tahun 2012 sampai dengan tahun 2016 dan metode pengambilan sampel menggunakan purposive sampling. Hasil penelitian ini ditemukan bahwa sustainability report tidak berpengaruh terhadap nilai perusahaan, hasil yang sama ditunjukkan pula oleh variabel kinerja lingkungan dimana kinerja lingkungan tidak berpengaruh terhadap nilai perusahaan sedangkan untuk variabel kinerja keuangan memiliki pengaruh signifikan terhadap nilai perusahaan
Los aspectos bioéticos en los pacientes con cáncer tratados mediante ensayos clínicos en Cuba
Authors: Rondón-Ayala José Alberto
Published: February 2019

Los aspectos bioéticos en los ensayos clínicos están regulados por organizaciones como la FDA, la Agencia Europea y, en Cuba, el Centro Nacional Coordinador de Ensayos Clínicos. El objetivo de este artículo es determinar la importancia de códigos, pautas y reglamentos para la seguridad y bienestar del sujeto de experimentación. Se ha utilizado como método la revisión sobre el tema de las bases de datos Medline, Hinari, Scielo, Springer, Wiley y otras en la página http://www.infomed.sld.cu. En conclusión, se analizaron los códigos, pautas y reglamentos sobre seguridad y bienestar del sujeto de experimentación, para que las personas con cáncer sean tratadas éticamente y no como medios u objetos.
Different VDR, VDBP genotypes and vitamin D levels may effect obstructive sleep apnea syndrome
Authors: Kirac Deniz , Yagcioglu Yassa Ozge , Gezmis Hazal , Mayda Domac Saime Fusun , Altunok Elif Cigdem , Genc Ece
Published: February 2019

Obstructive sleep apnea syndrome (OSAS) is a highly prevalent disorder which results in markedly reduced (hypopnea) or absent (apnea) airflow at the nose/mouth. Since vitamin D deficiency has found in an association with some disorders it is thought to be related with OSAS progression. The aim of this study is to investigate the association between VDR, VDBP mutations, vitamin D level and some environmental risk factors with OSAS. Fifty individuals who were diagnosed as OSAS were selected as patients, 50 healthy volunteers without any disease were selected as controls. FokI (rs2228570) and BsmI (rs1544410) mutations in VDR; rs4588 and rs7041 mutations in VDBP were investigated with quantitative real-time polymerase chain reaction (qPCR). Other risk factors were also investigated. Results were evaluated statistically. Statistically significant differences were observed according to the baseline characteristics between the groups, When groups were compared with each other, CA genotype in rs4588, CC genotype in rs2228570 and AA genotype in rs1544410 mutations were found statistically significant in patients whereas TC genotype in rs2228570 and GA genotype in rs1544410 mutations were found statistically significant in controls. When the relation between risk factors and genotypes were investigated, statistically significant associations were detected for body mass index (BMI), waist circumference, Apnea–Hypopnea Index (AHI), excessive daytime sleepiness (EDS), vitamin D and triglyceride levels. VDR and VDBP mutations were found highly related with OSAS. Possible tracking of these mutations and risk factors may help to understand the metabolism as well as the progression of the disease.
Kalokagathia and the Unity of the Virtues in the Eudemian Ethics
Authors: Bonasio Giulia
Published: February 2019

In this paper, I argue that in the Eudemian Ethics, Aristotle proposes a strong version of the unity of the virtues. Evidence in favor of this strong version of the unity of the virtues results from reading the common books within the EE rather than as part of the Nicomachean Ethics. The unity of the virtues as defended in the EE includes not only practical wisdom and the character virtues, but also all the virtues of practical and theoretical thinking. Closely related, in the EE, Aristotle proposes a different best agent from the one of the NE. The best agent of the EE is the kalos kagathos. The person who is kalos kagathos has “all” the virtues. Kalokagathia is a whole and the virtues are its parts. I investigate how we should understand this whole and the relation between the individual virtues within this whole.
Crystal structure of methyl 2-(4-(pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)acetate, C15H13N3O2
Authors: Fang Bo , Meng Jiang Ping , Luo Yan
Published: February 2019

C15H13N3O2, triclinic, P1̄ (no. 2), a = 4.6502(18) Å, b = 11.937(3) Å, c = 13.1822(19) Å, α = 115.26(4)°, β = 94.81(5)°, γ = 96.49(5)°, V = 650.4(4) Å3, Z = 2, R
gt(F) = 0.0762, wR
ref(F
2) = 0.1794, T = 296(2) K.
Crystal structure of catena-poly[(bis(μ-1,1′-[(5-methoxy-2,4,6-trimethyl-1,3-phenylene)bis(methylene)]bis(1H-1,2,4-triazole)-κ
2
N:N′)-bis(isothiocyanato-κN)manganese(II)], C34H40MnN14O2S2
Authors: Wang Mengyang , Yang Kaiqiang , Wang Yujiu , Ying Ying
Published: February 2019

C34H40MnN14O2S2, triclinic, P1̄ (no. 2), a = 9.1383(4) Å, b = 9.5039(6) Å, c = 10.5526(6) Å, α = 91.564(4)°, β = 94.624(5)°, γ = 91.737(4)°, V = 912.68(9) Å3, Z = 1, R
gt(F) = 0.0374, wR
ref(F
2) = 0.0910, T = 125 K.
Removal of Cs-137 and Sr-90 from reactor actual liquid waste samples using a new synthesized bionanocomposite-based carboxymethylcellulose
Authors: Emara Amr M. , El-Sweify Fatma H. , Abo-Zahra Shereen F. , Hashim Ahmed I. , Siyam Tharwat E.
Published: February 2019

A new biosorbent containing vinylsulphonic acid and 2-acryloamido-2-methyl-1-propanesulphonic acid in the presence of magnetic nanoparticles, iron (III) oxide, grafted to carboxymethylcellulose sodium salt P(VSA/AMPSO3H/MNPs)-g-CMC bionanocomposite material (BNC) has been synthesized by γ radiation induced grafting copolymerization technique. The effect of comonomer, crosslinker, CMC concentration and the absorbed dose (kGy) on the grafting efficiency and swelling degree was studied. The BNC has been successfully synthesized and the structure of the prepared BNC was confirmed by Fourier transform infrared (FTIR), thermal analysis (TGA and DTA), X-ray powder diffraction (XRD), high-resolution 1H NMR spectroscopy and scanning electron microscopy (SEM) micrograph. Batch studies relevant to adsorption of Cs-137 and Sr-90 from the reactor actual liquid waste samples by the BNC were performed as a function of contact time, solution pH, metal ion concentration, and temperature in simulation studies using the γ emitting isotopes Cs-134 and Sr-85 as representatives of Cs-137 and Sr-90, respectively. Those studies were used to find out the best conditions for isolation of Cs-137 and Sr-90 from reactor actual liquid waste. The isotherms and kinetics were analyzed using different models at 25 °C. The maximum capacity of BNC was found to be 297 and 330 mg g−1 for Cs(I) and Sr(II) metal ions, respectively.
Validity of Foot-To-Foot Bioelectrical Impedance for Estimating Body Composition in NCAA Division I Male Athletes: A 3-Compartment Model Comparison
Authors: Nickerson Brett S. , Snarr Ronald L. , Ryan Greg A.
Published: February 2019

Nickerson, BS, Snarr, RL, and Ryan, GA. Validity of foot-to-foot bioelectrical impedance for estimating body composition in NCAA Division I male athletes: A 3-compartment model comparison. J Strength Cond Res 33(12): 3361–3366, 2019—The purpose of this study was to validate single-frequency foot-to-foot bioelectrical impedance analysis (FF-BIA) against a 3-compartment (3C) model in NCAA Division I male athletes. Thirty-three athletes (football = 19, baseball = 8, basketball = 3, and cheerleading = 3) had body fat percentages (BF%) and fat-free mass (FFM) estimated using a 3C model and FF-BIA. The criterion 3C model was derived from body mass, body volume (air displacement plethysmography), and total body water (bioimpedance spectroscopy). The mean BF% and FFM values for FF-BIA were not statistically significant when compared with the 3C model (p = 0.14 and 0.28, respectively). The standard error of estimate (2.79% and 2.64 kg), total error (2.95% and 2.64 kg), and 95% limits of agreement (±5.67% and ±5.15 kg) were considered acceptable for BF% and FFM, respectively. However, there was a significant trend in the regression line of the Bland-Altman plot, which indicated proportional bias for BF% (r = −0.50; p < 0.01). No proportional bias was present for FFM (r = 0.26; p > 0.05). Foot-to-foot BIA seems to be valid for estimating group and individual athlete's FFM. Similarly, FF-BIA can be used for estimating group BF%. However, proportional bias indicates that FF-BIA is not valid for individual estimates of BF%.
Compression Stockings Used During Two Soccer Matches Improve Perceived Muscle Soreness and High-Intensity Performance
Authors: Gimenes Samuel Valencia , Marocolo Moacir , Pavin Larissa Neves , Spigolon Leandro Mateus Pagoto , Barbosa Neto Octávio , da Silva Bruno Victor Côrrea , Duffield Rob , da Mota Gustavo Ribeiro
Published: February 2019

Gimenes, SV, Marocolo, M, Pavin, LN, Pagoto Spigolon, LM, Neto, OB, Côrrea da Silva, BV, Duffield, R, and Ribeiro da Mota, G. Compression stockings used during two soccer matches improve perceived muscle soreness and high-intensity performance. J Strength Cond Res 35(7): 2010–2017, 2021—Evidence on the use of compression stockings (CS) during soccer matches is limited. Thus, we evaluated the acute effects of CS on match-based physical performance indicators and perceptual responses during 2 consecutive soccer matches with 72-hour recovery. Twenty outfield players were randomly allocated to the CS group (20–30 mm Hg) or control group (non-CS) and performed 2 matches (5 players using CS or regular socks per team/match). Match loads {rating of perceived exertion × minutes; CS ∼830 vs. control 843 (arbitrary units [AU])} and heart rate (HR) responses (both CS and control ∼86% HRpeak) did not differ (p > 0.05) between CS and control groups. Although total distance covered did not differ (p > 0.05) between groups, CS increased distances (effect size [ES] = 0.9–1.32) in higher-speed zones (>19 km·h−1 CS ∼550 m vs. control ∼373 m) alongside an increased number of accelerations (−50.0 to −3.0 m·s−2) than control (CS: 33.7 ± 11.2 vs. control: 23.8 ± 7.9; p = 0.003; ES = 1.04). Perceived recovery did not differ (p > 0.05) between groups for either match but was worse in the second match for both groups. Perceived muscle soreness increased in control after match 2 (from 3.1 ± 1.9 to 6.3 ± 1.6 AU; p < 0.0010) but did not in CS (from 2.8 ± 1.4 to 4.1 ± 1.9 AU; p = 0.6275; ES = 1.24 CS vs. control after match). Accordingly, CS use during 2 soccer matches with 72-hour recovery reduces perceived muscle soreness in the second match and increases higher-speed match running performance.
Screenings
Authors: Smith Paul Julian
Published: February 2019

FQ Columnist Paul Julian Smith reports from Mexico on Netflix's redo of the traditional telenovela with its new series, La casa de las flores (House of Flowers). Smith argues that the series is not as innovative or trangressive as it claims to be and in fact, was preceded in many aspects by the cult Mexican independent series Mirada de mujer (A Woman's Look) in the late 1990s. Both series feature a grumpy patriarch, a dissatisfied mother and wife who embarks on an affair (with a much younger man, in the case of Mirada de mujer), and three confused grown children, and both explore taboo topics such as AIDS, abortion, and interracial romance. Smith questions whether the U.S. newcomer, with its glossy production values, will prove to be as enduring as its homegrown predecessor.
Conformación geo-histórica de las actividades económicas en el Estado de Guerrero, México
Authors: García Castro Neftalí
Published: February 2019

Esta investigación sintetiza una serie de acontecimientos geo-históricos en torno a la configuración económico-productiva del estado de Guerrero. En el documento se presenta, 1) la secuencia que debe seguirse para confeccionar una matriz con los sucesos relevantes para un análisis desde la óptica geo-histórica, 2) paralelamente, se apuntan las razones fundamentales que soportan la selección de este enfoque y la solución metodológica propuesta, y 3) se revelan las etapas históricas con base en la forma de ocupación económica preponderante del territorio guerrerense. Lo anterior dio pauta para comprender porque ha tenido lugar el surgimiento de un número reducido asentamientos humanos considerados estratégicos para la estructuración territorial, pero con escasos efectos dinamizadores sobre espacios adyacentes.
Journeys to Justice: Reflections on Canadian Christian Activism by Joe Gunn
Authors: Hrynkow Christopher
Published: February 2019

In part one of Journeys to Justice, Joe Gunn presents ten chapters consisting of an introduction to a particular area of social concern, followed by a univocal, edited, and transcribed interview with a Canadian Christian activist associated with a prominent campaign within that area. Part two of the book, focusing on “Where We are Going”, consists of three contributions authored in response to part one.
La lengua escrita en preescolar: una propuesta socioconstructivista con apoyo de recursos informáticos
Authors: Luna Martínez María Teresa , Fortich Vivas Élida Patricia , Pinto Suárez Luis Carlos , Silva Cardozo Alexander
Published: February 2019

Este artículo expone los resultados de una investigación finalizada en el año 2016, con nueve niñas y seis niños del nivel de Educación Preescolar de una institución privada de la ciudad de Bucaramanga, Colombia. El objetivo fue mostrar los avances de su proceso escritor en un ambiente socio constructivista con el uso de recursos informáticos. Se ejecutó bajo el enfoque cualitativo, con diseño de investigación-acción y observación no participante. Se plantearon cuatro talleres sobre el tema de los seres vivos y no vivos, se hizo énfasis en el trabajo colaborativo con el apoyo de recursos informáticos, actividades de escritura con papel y lápiz, y en el computador, con el uso del teclado. Las evidencias resultantes se clasificaron según los niveles propuestos por Emilia Ferreiro: pre-silábico, silábico, silábico-alfabético y alfabético. Asimismo, se compararon los textos producidos por el cuerpo estudiantil en las dos modalidades, y se observó que, al final del proceso, seis estudiantes, en total, se ubicaron en el nivel alfabético en la modalidad lápiz y papel, mientras que con el uso del teclado solo dos. Al parecer, esto último se debió a que varios tuvieron su primer contacto con el computador en el trabajo de campo. Estos resultados evidencian, además, la necesidad de un preescolar dirigido al uso de recursos informáticos y a una didáctica encaminada al juego, a la cultura y a la socialización como excusa alfabetizadora, y pensado, de manera tal, que la niñez constituya el centro de alfabetización.
Manifestaciones violentas en contextos educativos: Prevención y acciones participativas
Authors: Mora Elizondo Lisbeth , Villalobos Barrantes Marietta
Published: February 2019

Este artículo surge a partir de los resultados del proyecto de investigación “La violencia dentro de las instituciones educativas: Una perspectiva desde las vivencias de los y las estudiantes de secundaria de la Región Pacífico Central (2010-2012)”, llevado a cabo en seis colegios públicos en esta región del pacifico costarricense. De ahí surge la inquietud de que urge abordar, desde una perspectiva preventiva, situaciones de conflicto y violencia que se dan dentro de los entornos educativos. La investigación explora, desde un enfoque cualitativo, las vivencias y creencias que el estudiantado atribuye a la violencia que vive en su colegio. Los instrumentos utilizados fueron dibujo proyectivo, grupo focal y entrevista semiestructurada. Participaron un total de ciento veintidós estudiantes, con edades entre once y dieciséis años. Los resultados muestran que existe violencia en muchos de los niveles de las relaciones educativas, violencia física, psicológica y simbólica, tanto fuera como dentro de las aulas. Se destaca la necesidad de pensar las desigualdades y las brechas educativas y sociales, construir vínculos educativos, redes de apoyo, y mejorar las metodologías educativas. Se realiza, desde las teorías psicosocial y de la subjetividad, una reflexión sobre la violencia dentro de los entornos educativos, desde el enfoque de la resiliencia, se culmina con la propuesta de un recurso psicopedagógico que permita a la población docente, abrir un espacio para reflexionar acerca del vínculo educativo e identificar la presencia o ausencia de capacidades resilientes, tanto en el estudiantado como a nivel institucional.
Identidad profesional y formación docente universitaria: Un proceso en construcción desde la mirada del estudiantado
Authors: Miranda Cervantes Giselle , Vargas Dengo Marie-Claire
Published: February 2019

Este artículo consiste en un estudio longitudinal realizado entre los años 2014-2017 con tres grupos de estudiantes del nivel de Diplomado de Pedagogía con énfasis en I y II ciclos, Educación Especial y Pedagogía con énfasis en Educación Preescolar, que se imparten en la División de Educación Básica (DEB) del Centro de Investigación en Docencia y Educación (CIDE) de la Universidad Nacional (UNA) en Costa Rica y se elabora en el marco del proyecto Identidad Docente: Resignificando la labor profesional adscrito a la DEB. Desde una fase metodológica indagatoria, se aplicó un cuestionario a diversos grupos de estudiantes en el año 2014 y posteriormente se reaplicó el cuestionario a las mismas personas participantes en el año 2017, esto con el fin de valorar la escogencia personal de cursar una carrera de formación docente, así como el apoyo recibido por parte de su familia durante la formación universitaria. Los resultados señalan que el estudiantado se identifica claramente con ser docente, identificación que se fortalece a lo largo de su proceso formativo aun cuando no todas las estudiantes y ni todos los estudiantes se visualizan para ejercer la docencia como profesión durante toda su vida futura. Además, se presentan diferencias sobre la escogencia de la profesión docente como formación inicial y la percepción del reconocimiento social de esta profesión. Se concluye que es indispensable contribuir desde los centros y facultades de educación a la formación inicial docente y al desarrollo profesional de la educadora y el educador costarricenses.
Importancia del desarrollo de la inteligencia emocional en la formación de personas investigadoras
Authors: Fragoso-Luzuriaga Rocio
Published: February 2019

Este ensayo, producto de la revisión de diversos artículos científicos, tiene por objetivo fundamentar la importancia del desarrollo de la Inteligencia Emocional (IE) en la formación de personas investigadoras. Para cumplir con el propósito anterior, primero se presenta la labor científica como un proceso emocional; luego aborda las relaciones sociales que contribuyen o entorpecen el desarrollo de futuras personas profesionales de la investigación; seguidamente expone cómo las competencias emocionales, propuestas por el modelo mixto de Goleman, auxilian en el proceso de investigación; posteriormente, se analiza cómo las diferentes habilidades del modelo de IE propuesto por Mayer y Salovey son claves en la labor científica; por último se muestran diversas recomendaciones para fomentar la IE en la formación de personas investigadoras. Finalmente, se desarrollan las conclusiones del ensayo donde se resalta la relevancia de la IE en investigadores e investigadoras en formación.