bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrogeological regime and groundwater occurence in the Anthemountas River Basin
Authors: Kazakis N. , Voudouris K. , Vargemezis G. , Pavlou A.
Published: January 2017

The Anthemountas river basin is located in northern Greece and covers an area of 374 km2. The mountainous part of the basin consists of ophiolitic, crystalline and carbonate rocks, whereas the lowlands comprise Neogene and Quaternary sediments. Porous aquifers are developed in neogene and quaternary deposits of confined and/or unconfined conditions. Karstic aquifers are developed in the carbonate rocks and there are aquifers in the Mesozoic and Palaeozoic fissured rocks. The water demands of the basin are mainly met by the exploitation of the porous aquifers through a large number of boreholes (more than 1000). The aquifers of fissured rocks discharge through cold springs without significant flow rate. Thermal hot springs are recorded across the Anthemountas fault discharging a mixture of geothermal fluids and cold water from the karst aquifer. According to their hydrogeological and lithological characteristics, porous aquifers can be divided into the subsystems of Galatista and Galarinos in the eastern part of the Anthemountas basin, Vasilika-Risio-Thermi and Tagardes-Trilofos in the western part and Peraia-Agia Triada and AUTh farm-Makedonia airport in the coastal area. For the determination of the aquifers (geometry and anatomy), their recharge mechanisms and hydraulic connection, data from geological maps, lithological profiles, geoelectrical soundings and tomographies, pumping tests and groundwater level measurements are used.
Flood and groundwater management for the mountain plateau of Omalos based on geoinformatics techniques
Authors: Kourgialas N.N. , Karatzas G.P.
Published: January 2017

A viable approach for flood and groundwater management in a mountain Plateau based on geoinformatics techniques is presented in this work. The proposed water management plan has two components: (a) the determination of the flood-hazard areas, and (b) the estimation of groundwater flow. For the first component, six factors were considered in order to estimate the spatial distribution of the flood hazardous areas: elevation, slope, land use, rainfall intensity, geology, and flow accumulation, The study area was divided into five regions characterized by different degrees of flood hazard ranging from very low to very high. The produced map of flood-hazard areas identifies the areas at high risk of flooding. The second component includes a groundwater management approach for estimating groundwater flow and the potential contamination risk. The proposed methodology can be used to objectively compare different scenarios based on anthropogenic interventions that can affect the flood-prone areas or the groundwater flow dynamic. All these approaches were applied at the Omalos Plateau in the White Mountains of Crete in Greece.
Analytical geochemistry in the service of medicine: An experimental study of urinary stones from Northern Greece
Authors: Iordanidis A. , Garcia-Guinea J.
Published: January 2017

Knowledge of the precise human biomineral composition may allow physicians to recommend an appropriate prophylactic therapy for the patient and thus prevent or delay the stone recurrence. The present study focuses on the application of complementary analytical techniques to the characterization of human urinary stones. Several gallbladder and renal stone samples were obtained from patients dwelling in areas of northern Greece. A comprehensive analytical study took place, employing the following, common in analytical geochemistry, techniques: Environmental Scanning Electron Microscopy (ESEM) coupled to Energy Dispersive System (EDS), X-Ray Diffraction (XRD), thermogravimetry (TG), μRaman spectroscopy and Cathodoluminescence (CL). A detailed determination of morphological, micro-structural, molecular, chemical and mineralogical characteristics of the urinary stone samples was achieved. It was evident by our study the application of powerful analytical techniques could substantially help the medical advisors to ascribe a medical treatment of diseases related to stone formation.
MIOCENE SCLERACTINIAN CORALS OF GAVDOS ISLAND, SOUTHERN GREECE: IMPLICATIONS FOR TECTONIC CONTROL AND SEA-LEVEL CHANGES
Authors: Drinia H. , Pomoni-Papaioannou F. , N. Tsaparas , Antonarakou A.
Published: January 2017

Low-diversity scleractinian patch reefs that have been developed, during Early to Middle Tortonian, in Gavdos island are studied, aiming in a better understanding of the time and space relationships of the reef development and the associated basin fill evolution. Gavdos island consists part of a tectonically active setting constituting the southernmost extension of the Hellenic arc (Eastern Mediterranean). A representative Tortonian section (Bo section), located in the northwest part of the island, which hosts a mass occurrence of hermatypic corals, is studied. Scleractinian samples were collected from the upper 12 m of the section, which is characterized by interchanges of marly limestone and compact marls. The reefs are represented by the coral species Heliastraea oligophylla, Porites maicientensis, Thegioastraea roasendai and Porites collegniana. The microfacies analysis showed that the mediumto-thin-bedded carbonates of the limestone-marl alternations comprise patch reefs (boundstones-framestones, SMF 16, sensu Wilson, 1975, FZ 7-8, sensu Flügel 1982) consisted of screractinian corals. Corals are associated with corallinacean algae. Patch reefs are associated by bioclastic packstones-floatstones, characterized by benthic foraminifera, calcareous algae, spines of echinoids, gastropods and molluscs. Reefs are laterally associated by a bioclastic limestone rich in planktonic forams, associated by detrital material (fragments of quartz, feldspars, quartzites and cherts). The studied reef facies have been dolomitized and cemented in the meteoric realm. In places pseudomorphs after evaporites have been observed, tending to occlude cavities resulted after dissolution. The depositional environment corresponds to a moderate to high-energy inner platform setting, experiencing open-ocean influences. The pattern of coralgal reef development during Miocene, in the tectonically controlled Gavdos island, represents a complex interaction of tectonic activity and global sea-level changes.
SELECTION OF THE PATH OF THE EUPALINOS AQUEDUCT AT ANCIENT SAMOS ON THE BASIS OF GEODETICAND GEOLOGICAL / GEOTECHNICAL CRITERIA
Authors: Stiros S. , Kontogianni V.
Published: January 2017

The tunnel of Eupalinos at Samos (Greece) is certainly one of the most admirable works in antiquity, but several questions concerning its plan, and especially the selection of its path, leading to an ‘S’ type curve, a longer tunnel and a longer aqueduct remain without an answer. In this paper we try to provide an answer to the question ‘why Eypalinos selected the specific path for the aqueduct?’ on the basis of geotechnical and geodetic evidence. Two basic criteria should have been satisfied for the tunnel planning: first, that it had to be excavated through rocks with mechanical properties suitable for a safe underground excavation, and second, that the portals should have been in areas permitting accurate geodetic orientation and guidance of the excavation. The overall selection of the tunnel path indicates that Eupalinos had an excellent understanding of the theory of errors and an ability for geological and geotechnical evaluation of the mechanical characteristics of the ground, i.e. a primitive system of the rock strength classification, with remarkable similarities with the modern GSI method.
ΠΡΟΛΟΓΟΣ
Authors: Geological Society of Greece Geological Society of Greece
Published: January 2017

no abstract available
GIS IN URBAN GEOLOGY: THE CASE STUDY OF NAFPLIO, ARGOLIS PREFECTURE, GREECE
Authors: Zervakou A.D. , Tsombos P.
Published: January 2017

The aggregation of population in big cities leads to the concentration of human activities, overconsumption of natural resources and urban growth without spatial planning and sustainable management. As a result, urban societies are exposed to various dangers and threats with economic, social, ecological, and environmental impacts on the urban surroundings. Problems associated with urban development are related to the existing geological conditions. Therefore, the provision of appropriate geological information about the urban environment is essential for every sustainable urban planning. The first systematic recording, codification and documentation of “Urban Geology” geothematic information in Greece was implemented by the Institute of Geology and Mineral Exploration (I.G.M.E.) in the framework of the project called “Collection, codification and documentation of geothematic information for urban and suburban areas in Greece - pilot applications”. Through the implementation of this project, geological mapping, geotechnical, geochemical, geophysical research and measurements took place at four pilot cities of Greece. Nafplio, the capital city of Argolis prefecture, was one of them. During the project, all compiled data were stored and processed in specially designed geodatabases in GIS environment in order to produce multifunctional geothematic maps and other digital products (DEMs, 2D - 3D surfaces).
A MATLAB PROGRAM FOR THE ANALYSIS AND INTERPRETATION OF TRANSIENT ELECTROMAGNETIC SOUNDING DATA
Authors: Tzanis Andreas
Published: January 2017

Herein we present a software system, written in MATLAB, to interpret TEM sounding data. The program, dubbed maTEM, is designed to process, model and invert multiple soundings, either individually, or simultaneously along profiles. The latter capability allows for laterally constrained inversion, so as to generate pseudo-2D or 2D resistivity sections based on the program EM1DINV v2.13 by the Hydro-Geophysics Group of the University of Aarhus, Denmark. Using maTEM, the analyst may import and display data multiple data sets, denoise and smooth the data, perform approximate inversions, design 1-D model(s) graphically, perform forward modelling and inversion and generate/ update data base in which to store the results. Finally, the analyst may use the data base to create 2-D and 3-D displays of the geoelectric structure with built-in graphical functions. maTEM is highly modular so that additional functions can be added at any time, at minimal programming cost. Although the software presented herein is focused on the analysis of TEM data, the maTEM concept has been designed ready to incorporate additional electrical and EM geophysical sounding methods and to mutually constrained analysis of different geophysical data sets.
Ο flâneur: θεωρητικές μεταμορφώσεις μιας παρισινής φιγούρας
Authors: Γκότση Γεωργία
Published: January 2017

Δεν διατίθεται περίληψη.
Traduction des connaissances arabes
Authors: Abbassa Mohammed
Published: January 2017

Η μελέτη αναφέρεται στη μετάφραση των αραβικών γνώσεων που πραγματοποιήθηκε στην Ευρώπη τον Μεσαίωνα από Χριστιανούς, Μουσουλμάνους και Εβραίους. Πρέπει να υπογραμμίσουμε ότι σχεδόν ολόκληρη η αραβική φιλοσοφία και η ιστορία των Μουσουλμάνων καθώς και έργα της λογοτεχνίας μεταφράστηκαν από τα αραβικά σε γλώσσες λατινικές και στα εβραϊκά. Οι Ευρωπαίοι που ενδιαφέρθηκαν για τις αραβικές επιστήμες δεν είχαν τις ίδιες προθέσεις, οι στόχοι τους ήταν πολιτικοί, θρησκευτικοί ή επιστημονικοί. Η τάση της μετάφρασης έργων της αραβο-ισλαμικής παιδείας αναπτύχθηκε ιδιαίτερα στην Ευρώπη κατά τον 12ο και τον 13ο αιώνα, οταν οι Άραβες λόγιοι εκδιώχθηκαν από την Ανδαλουσία. Αυτοί οι φιλόσοφοι και άνθρωποι των επιστημών κατέφυγαν στον Βορρά όπου αφιερώθηκαν στη μετάφραση προς όφελος των Χριστιανών.
Γιώργος Σαραντάρης και Τζιουζέππε Ουγκαρέττι: μια συγκριτική προσέγγιση των έργων τους
Authors: Macrì Gabriella
Published: January 2017

Δεν διατίθεται περίληψη.
Θέατρο και Διαφορότητα : Η Κωμωδία της Μύγας του Βασίλη Ζιώγα και Ο Κήπος των Ηδονών του Fernando Arrabal
Authors: Σαμαρά Ζωή
Published: January 2017

[Δεν υπάρχει περίληψη]
Το Τρίο σε Μι-μπεμόλ τον Ερίκ Ρομέρ και η Ελληνική του Πρώτη «Εκτέλεση»: Μια Τριπλή Ανα-σύνθεση;
Authors: Τσατσάκου Αθανασία
Published: January 2017

[Δεν υπάρχει περίληψη]
Τόμας Μαν, Αντρέ Ζιντ και Ευρώπη: Όψεις μιας Θεώρησης της Λογοτεχνίας, υπερβαίνοντας τα Σύνορα
Authors: Schmeling Manfred
Published: January 2017

[Χωρίς περίληψη]
Χειρόγραφες μεταφράσεις της περιόδου του διαφωτισμού: επιβιώσεις, απουσίες, ανανεώσεις: μία πρώτη ανίχνευση των συλλογών της Εθνικής Βιβλιοθήκης της Ελλάδας
Authors: Χατζημάνου Δήμητρα
Published: January 2017

[Δε διατίθεται περίληψη]
Medical and Economic Burden of Heparin‐Induced Thrombocytopenia: A Retrospective Nationwide Inpatient Sample (NIS) Study
Authors: Pathak Ranjan , Bhatt Vijaya Raj , Karmacharya Paras , Aryal Madan Raj , Donato Anthony A.
Published: February 2017

In recent years, US hospitals have switched from use of unfractionated heparin to use of low‐molecular‐weight heparin, which is associated with lower risk of heparin‐induced thrombocytopenia (HIT). In the study reported here, we retrospectively searched the Nationwide Inpatient Sample (NIS) for patients who were at least 18 years old and received a diagnosis of HIT between 2009 and 2011. Our goal was to get an updated perspective on the incidence and economic impact of HIT. We calculated the incidence of HIT overall and in subgroups of patients who underwent cardiac, vascular, or orthopedic surgery. We compared characteristics of patients with and without HIT and compared characteristics of patients with HIT with thrombosis (HITT) and HIT patients without thrombosis. Of 98,636,364 hospitalizations, 72,515 (0.07%) involved HIT. Arterial and venous thromboses were identified in 24,880 (34.3%) of HIT cases. Men were slightly more likely to have a HIT diagnosis (50.1%), but women had higher rates of HIT after cardiac surgery (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.26‐1.58) and vascular surgery (OR, 1.42; 95% CI, 1.29‐1.57). Rates of HIT were 0.53% (95% CI, 0.51%‐0.54%) after cardiac surgery, 0.28% (95% CI, 0.28%‐0.29%) after vascular surgery, and 0.05% (95% CI, 0.05%‐0.06%) after orthopedic surgery. HIT and HITT cases were significantly (P < 0.001) more likely than non‐HIT cases to be fatal (9.63% and 12.28% vs 2.19%), and they had significantly higher costs and longer inpatient stays. HIT and especially HITT are associated with increased mortality, costs, and length of stay.
The role of genetic factors in predicting results of obesity treatment with sibutramine – serotonin-norepinephrine reuptake inhibitor
Authors: Galieva Marina , Troshina Ekaterina , Mazurina Nataliya , Artiushin Andrey , Pavlova Anastasia , Volynkina Anna , Aksyonova Marina , Logvinova Oksana
Published: January 2017

Aim. To study the influence of SERT and GNB3 gene polymorphisms on the results of the treatment of obesity by serotonin-norepinephrine reuptake inhibitors.Methods. Patients who didn’t achieve significant weight loss in 3 month period during PrimaVera Study were selected for the genetic evaluation and compared with the group of “effective treatment”. The study included 66 patients (57 females and 9 males), mean age 39.29 ± 12.64 years, who received Reduxin (sibutramine + MCC) at the dose of 10 mg. Term follow-up was 3 months. Clinical examination and determination of biochemical parameters was performed at baseline and at the end of the observation period. In order to assess the type of eating behavior and identify hidden depressions a validated questionnaire was used (questionnaire "The types of eating disorders» (DEBQ), Beck Depression Scale). Also conducted a genetic study to assess SERT and GBN3 gene polymorphisms.Results. In the second group presence of S-allele SERT-gene was significantly associated with higher rates of external type of eating behavior. A statistically significant correlation between the genotype or allele of either body weight, rates of blood pressure, heart rate and cholesterol have not been found. In the first group there was a statistically significant association of S-allele carrier with less weight loss -2.8 kg (compared to l-allele) and higher rates at baseline glucose 5.38 ± 0.63 mmol / l (compared to L-allele of -3.28 kg and 5.04 ± 0.91 mmol / l).In the study of GBN3 polymorphism in the second group among CC genotype carriers there were higher levels of systolic blood pressure (SBP) before treatment (129.27 ± 9.16 mmHg), SBP and diastolic blood pressure after 3 months of treatment (127.36 ± 8.16 and 78.36 ± 4.3 mmHg) compared with CT genotype (117.27 ± 12.5; 115.45 ± 10.6; 72.91 ± 6.0 mm Hg, respectively) (p 0.05). Also among the carriers of C-allele there were more severe manifestations of depressive syndrome in comparison with T-allele carriers.Conclusion. Among the carriers of S-allele of SERT gene body weight loss during Reduxin treatment was lower than among the carriers of the L-allele; among the carriers of CC genotype of GBN3 gene higher blood pressure was higher at baseline and during Reduxin treatment, as well as more severe symptoms of a depressive syndrome.
Socio-medical aspects of the normalization of body mass
Authors: Leskova Irina , Ermakov Dmitriy , Matushevskaya Elena , Nishnianidze Ol'ga
Published: January 2017

Increased body mass index (BMI) in today's world has become one of the most common and extremely dangerous to humanity diseases. The expansion of fast food chains, high-calorie food, sedentary lifestyle, stress, accumulation of population in cities – the main causes of overweight. In the twenty-first century, in scientific literature introduced a new term "globesity", reflecting the global nature of global problems. However, studies in recent years, several break this logic: "overweight – obesity – the risk of chronic diseases – the risk of premature death." Often, those with elevated BMI have a greater life expectancy than patients with normal or decreased BMI. The latter causes the appearance of a new term "obesity paradox". Indeed, increased BMI significantly reduces the quality of life, increases the risk of social problems. Persons suffering from increased BMI, harder to find a job and to arrange his personal life. In the United States of America the presence of increased body mass index (BMI) results in a significant rise in the cost of health insurance. Reducing excess weight is completely dependent on patients who need along with medication to live a healthy lifestyle. An important direction of minimize obesity and its consequences seem to be a diet, refusal of personal transport, leisure, vacation travel. American society of specialists in the field of metabolic and bariatric surgery define obesity as a chronic, relapsing, multifactorial neurobehavioral disorder in which the increase of fat in the body contributes to the dysfunction of adipose tissue with the development of threat for physical and psychological health of the metabolic and psychosocial consequences.
Impact of different fertilizers on some phytochemical constituents and biological activities of Beta vulgaris L. leaves
Authors: Farouk Ghada , Mostafa Horia
Published: January 2017

Red beet leaves are used in some countries in salads, while others consider them as leftover. Our goal is to conduct field experiment, for two seasons, to evaluate the effect of various combinations of (organic, chemical and bio-/yeast) fertilizers and different harvest dates on some leaves growth parameters, biocostituents and biological activities. The applied fertilizers significantly increased most of the growth parameters compared to control and highest values were produced by 100%chemical fertilizer (2), followed by treatments of 75%biofertilizer (4) and 75%yeast (8). Highest chlorophyll (a&b) and carotenoids contents were recorded by treatments 2, 4 and 8, particularly those of the second stage. Most of the studied fertilizers significantly increased betanin and polyphenolic contents compared to control and highest values were attained by treatments 4 and 8. Maximum values of betanin and polyphenols were reached in the first and third stages, respectively. Additionally, highest antioxidant activity was afforded by leaves of treatments 4 and 8, whereas leaves of treatment 4 provided a broader antimicrobial activity than control. Moreover, the highest cytotoxic activity was exerted by leaves of treatment 4. Finally, it is recommended to harvest beet leaves at the appropriate stage to obtain high growth values and reasonable percentages of bioactive metabolites.
Aprendizaje de estudiantes de secundaria sobre la naturaleza de la ciencia mediante el caso histórico de semmelweis Y la fiebre puerperal -Learning of high school students about the nature of science through the historical case of semmelweis And puerperal fever
Authors: Aragón-Méndez María del Mar , García-Carmona Antonio , Acevedo-Díaz José Antonio
Published: January 2017

Se presentan los resultados de la evaluación de una actividad para el aprendizaje de algunos aspectos de naturaleza de la ciencia (NDC), empleando como contexto el caso histórico de la investigación de Semmelweis sobre la fiebre puerperal. La actividad está dirigida a estudiantes de 4º curso de Educación Secundaria (15-16 años), y se ha implementado mediante un enfoque explícito y reflexivo. Para la evaluación del aprendizaje de los estudiantes se usa una rúbrica, que se aplica mediante un proceso de análisis inter-jueces, y el diario de la profesora. Globalmente, los resultados indican una progresión de las ideas iniciales de los estudiantes sobre NDC, con un nivel de comprensión moderado respecto a los aspectos epistémicos, y mayor en los no-epistémicos. Por tanto, se evidencia el potencial didáctico de la actividad para aprender sobre NDC. Finalmente, se indican algunas implicaciones educativas de la experiencia.
Consideraciones para un Programa de Desarrollo Profesional que orienta al profesor a re-conceptualizar su enseñanza -Considerations for a Professional Development Program that instructs teachers to re-conceptualize their teaching
Authors: Ravanal-Moreno Eduardo
Published: January 2017

Las demandas por una enseñanza de calidad ponen el acento indiscutiblemente en el rol del profesor, por lo tanto, se debe contribuir a su desarrollo a partir de programas que se focalicen en los requerimientos y necesidades profesionales que exige una enseñanza de calidad. En ese marco, un sistema de desarrollo profesional que enfatiza en la actualización y perfeccionamiento del profesor sobre la disciplina y las técnicas de enseñanza como lo plantea la política pública en Chile, quizás, no sea la solución plausible para promover una enseñanza de calidad por la racionalidad técnica que lo orienta. El artículo busca aportar a la discusión sobre el conocimiento didáctico del contenido como un eje para el desarrollo profesional del profesor de biología por su alta incidencia en la enseñanza. Se presta atención a los aspectos implicados en el desarrollo profesional y al conocimiento didáctico como un requerimiento profesional necesario para la enseñanza. Se proponen algunas consideraciones para el diseño de un programa de desarrollo profesional que oriente al profesorado a cambiar su epistemología personal para una nueva conceptualización de la práctica pedagógica, entre ellas: (i) Trabajar con el profesorado desde sus preocupaciones profesionales en una plano cognitivo, contextual y situado, (ii) Promover una actividad de reflexión que favorezca el transito entre los dominios: personal, fuentes, práctico y de consecuencia de enseñanza y, (iii) Discutir teóricamente los nuevos cuestionamientos para enfrentar las dificultades de la enseñanza y re-estructurar  el conocimiento didáctico del contenido del profesor.
Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease
Authors: Ye Xuan , Feng Tuancheng , Tammineni Prasad , Chang Qing , Jeong Yu Young , Margolis David J. , Cai Huaibin , Kusnecov Alexander , Cai Qian
Published: February 2017

Amyloid-β (Aβ) peptides play a key role in synaptic damage and memory deficits in the early pathogenesis of Alzheimer's disease (AD). Abnormal accumulation of Aβ at nerve terminals leads to synaptic pathology and ultimately to neurodegeneration. β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the major neuronal β-secretase for Aβ generation. However, the mechanisms regulating BACE1 distribution in axons and β cleavage of APP at synapses remain largely unknown. Here, we reveal that dynein–Snapin-mediated retrograde transport regulates BACE1 trafficking in axons and APP processing at presynaptic terminals. BACE1 is predominantly accumulated within late endosomes at the synapses of AD-related mutant human APP (hAPP) transgenic (Tg) mice and patient brains. Defective retrograde transport by genetic ablation ofsnapinin mice recapitulates late endocytic retention of BACE1 and increased APP processing at presynaptic sites. Conversely, overexpressing Snapin facilitates BACE1 trafficking and reduces synaptic BACE1 accumulation by enhancing the removal of BACE1 from distal AD axons and presynaptic terminals. Moreover, elevated Snapin expression via stereotactic hippocampal injections of adeno-associated virus particles in mutant hAPP Tg mouse brains decreases synaptic Aβ levels and ameliorates synapse loss, thus rescuing cognitive impairments associated with hAPP mice. Altogether, our study provides new mechanistic insights into the complex regulation of BACE1 trafficking and presynaptic localization through Snapin-mediated dynein-driven retrograde axonal transport, thereby suggesting a potential approach of modulating Aβ levels and attenuating synaptic deficits in AD.

SIGNIFICANCE STATEMENTβ-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) trafficking and synaptic localization significantly influence its β secretase activity and amyloid-β (Aβ) production. In AD brains, BACE1 is accumulated within dystrophic neurites, which is thought to augment Aβ-induced synaptotoxicity by Aβ overproduction. However, it remains largely unknown whether axonal transport regulates synaptic APP processing. Here, we demonstrate that Snapin-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Aβ production. Adeno-associated virus–mediated Snapin overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Aβ levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway that controls synaptic APP processing by enhancing axonal BACE1 trafficking, thereby advancing our fundamental knowledge critical for ameliorating Aβ-linked synaptic pathology.
Organization of the Anterior Limb of the Internal Capsule in the Rat
Authors: Coizet Veronique , Heilbronner Sarah R. , Carcenac Carole , Mailly Philippe , Lehman Julia F. , Savasta Marc , David Oivier , Deniau Jean-Michel , Groenewegen Henk J. , Haber Suzanne N.
Published: February 2017

Dysfunction of the orbitofrontal (OFC) and anterior cingulate (ACC) cortices has been linked with several psychiatric disorders, including obsessive-compulsive disorder, major depressive disorder, posttraumatic stress disorder, and addiction. These conditions are also associated with abnormalities in the anterior limb of the internal capsule, the white matter (WM) bundle carrying ascending and descending fibers from the OFC and ACC. Furthermore, deep-brain stimulation (DBS) for psychiatric disorders targets these fibers. Experiments in rats provide essential information on the mechanisms of normal and abnormal brain anatomy, including WM composition and perturbations. However, whereas descending prefrontal cortex (PFC) fibers in primates form a well defined and topographic anterior limb of the internal capsule, the specific locations and organization of these fibers in rats is unknown. We address this gap by analyzing descending fibers from injections of an anterograde tracer in the rat ACC and OFC. Our results show that the descending PFC fibers in the rat form WM fascicles embedded within the striatum. These bundles are arranged topographically and contain projections, not only to the striatum, but also to the thalamus and brainstem. They can therefore be viewed as the rat homolog of the primate anterior limb of the internal capsule. Furthermore, mapping these projections allows us to identify the fibers likely to be affected by experimental manipulations of the striatum and the anterior limb of the internal capsule. These results are therefore essential for translating abnormalities of human WM and effects of DBS to rodent models.

SIGNIFICANCE STATEMENTPsychiatric diseases are linked to abnormalities in specific white matter (WM) pathways, and the efficacy of deep-brain stimulation relies upon activation of WM. Experiments in rodents are necessary for studying the mechanisms of brain function. However, the translation of results between primates and rodents is hindered by the fact that the organization of descending WM in rodents is poorly understood. This is especially relevant for the prefrontal cortex, abnormal connectivity of which is central to psychiatric disorders. We address this gap by studying the organization of descending rodent prefrontal pathways. These fibers course through a subcortical structure, the striatum, and share important organization principles with primate WM. These results allow us to model primate WM effectively in the rodent.
Dutch Batik Motifs: The Role of The Ruler and The Dutch Bussinesman
Authors: Patria Asidigisianti Surya
Published: February 2017

Dutch Batik is the referent of batik which is made by European-Indo woman industry. It can be identified by the European pattern which is a bouquet. This research is aimed to describe the correlation between the development of Dutch Batik with the role of the Dutch government and the Dutch merchant. The library research was used during analyzing the role of the government and the merchant using the Talcott Parsons’ functional structure theory. The batik Dutch companies were commercial oriented. It is different from real Javanese batik which had a purpose to be worn by themselves. Dutch Batik was the expression of the idea and behavior of the Dutch who lived in Indonesia. They expressed their western by using the patterns that were shown in their batik.
Sundanese Traditional Tone Sensitivity-Based Audiation Model of Salendro Musical Scale
Authors: Latifah Diah
Published: February 2017

This study is aiming at finding out the audiation model of salendro musical scale and teaching it to the non-Sundanese learners. Treatment done to the learners whose hearing sensitivity has not been familiar with salendro tone during the audiation practice. A method implemented in the study was grounded theory. It was used to explore initial audiation theory from Edwin E. Gordon in Syntax Learning Sequence in Music that was adjusted with learning stages of salendro tone. This study resulted in an audiation model of salendro tone to sharpen hearing sensitivity of non-Sundanese learners who had not been familiar with salendro tone.
The management of metastatic radioiodine-refractory differentiated thyroid cancer requires an integrated approach including both directed and systemic therapies
Authors: Cooray Shamil D , Topliss Duncan J
Published: February 2017

A 58-year-old man with metastatic radioiodine-refractory differentiated thyroid cancer (DTC) presented with left thigh and right flank numbness. He had known progressive and widespread bony metastases, for which he received palliative radiotherapy, and multiple bilateral asymptomatic pulmonary metastases. CT scan and MRI of the spine revealed metastases at right T10–L1 vertebrae with extension into the central canal and epidural disease at T10 and T11 causing cord displacement and canal stenosis but retention of spinal cord signal. Spinal surgery was followed by palliative radiotherapy resulting in symptom resolution. Two months later, sorafenib received approval for use in Australia and was commenced and up-titrated with symptomatic management of mild adverse effects. Follow-up CT scan three months after commencement of sorafenib revealed regression of pulmonary metastases but no evident change in most bone metastases except for an advancing lesion eroding into the right acetabulum. The patient underwent a right total hip replacement, intra-lesional curettage and cementing. After six months of sorafenib therapy, CT scanning showed enlarging liver lesions with marked elevation of serum thyroglobulin. Lenvatinib was commenced and sorafenib was ceased. He now has stable disease with a falling thyroglobulin more than 5 years after metastatic radioiodine-refractory DTC was diagnosed.

In DTC, 5% of distant metastases become radioiodine-refractory, resulting in a median overall survival of 2.5–3.5 years. Tyrosine kinase inhibitor (TKI) therapy has recently been demonstrated to increase progression-free survival in these patients but poses some unique management issues and is best used as part of an integrated approach with directed therapy.

Learning points:

Directed therapies may have greater potential to control localised disease and related symptoms when compared to systemic therapies.

Consider TKI therapy in progressive disease where benefits outweigh risks.

Active surveillance and timely intervention are required for TKI-related adverse effects.

There is a need for further research on the clinical application of TKI therapy in advanced DTC, including comparative efficacy, sequencing and identifying responders.
Studies of an Androgen-Binding Protein Knockout Corroborate a Role for Salivary ABP in Mouse Communication
Authors: Chung Amanda G , Belone Phillip M , Bímová Barbora Vošlajerová , Karn Robert C , Laukaitis Christina M
Published: February 2017

The house mouse Androgen-binding protein (Abp) gene family is comprised of 64 paralogs, 30 Abpa and 34 Abpbg, encoding the alpha (ABPA) and beta-gamma (ABPBG) protein subunits that are disulfide-bridged to form dimers in secretions. Only 14 Abp genes are expressed in distinct patterns in the lacrimal (11) and submandibular glands (3). We created a knockout mouse line lacking two of the three genes expressed in submandibular glands, Abpa27 and Abpbg27, by replacing them with the neomycin resistance gene. The knockout genotype (−/−) showed no Abpa27 or Abpbg27 transcripts in submandibular gland complementary DNA (cDNA) libraries and there was a concomitant lack of protein expression of ABPA27 and ABPBG27 in the −/− genotype saliva, shown by elimination of these two proteins from the saliva proteome and the loss of cross-reactive material in the acinar cells of the submandibular glands. We also observed a decrease in BG26 protein in the −/− animals, suggesting monomer instability. Overall, we observed no major phenotypic changes in the −/− genotype, compared with their +/+ and +/− siblings raised in a laboratory setting, including normal growth curves, tissue histology, fecundity, and longevity. The only difference is that male and female C57BL/6 mice preferred saliva of the opposite sex containing ABP statistically significantly more than saliva of the opposite sex without ABP in a Y-maze test. These results show for the first time that mice can sense the presence of ABP between saliva targets with and without ABPs, and that they spend more time investigating the target containing ABP.
Biofilm en Endodoncia: una revisión
Authors: Zambrano de la Peña Sonia , Salcedo-Moncada Doris , Petkova- Gueorguieva Marieta , Ventocilla Huasupoma María
Published: January 2017

Están demostrados los esfuerzos que han hecho la Microbiología y la ciencia endodóntica para llegar a descifrar los secretos de esta singular estructura a pesar de que día tras día van surgiendo nuevos inte-rrogantes. Necesitamos que los tratamientos que empleemos para combatir al biofilm logren oxigenar el ecosistema periapical y fundamentalmente raspar y desprender las bacterias fuertemente adheridas. Conociendo el proceso de formación del Biofilm, el metabolismo microbiano y las estrategias que ellos mismos utilizan para resistir y permanecer ocultos pero activos, sabremos por qué llegamos a observar lesiones periapicales refractarias.
Segurança pública e reforma das polícias na América Latina
Authors: Sozzo Máximo , Azevedo Rodrigo Ghiringhelli de
Published: January 2017

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Interfaces de um intercâmbio de doutorado: formação de professores e experiências relevantes
Authors: Soares Elane Chaveiro
Published: January 2017

Neste texto apresento a construção de conhecimento proporcionada pelo intercâmbio de Doutorado realizado na cidade de La Plata/Argentina, a partir do convênio entre a Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) e a Universidade Nacional de La Plata (UNLP)/financiado pela CAPES. Pude estudar por três meses (agosto a outubro/2011) nesta universidade e participar ativamente de quatro importantes atividades realizadas neste período. Primeiro como ouvinte do VIII Encuentro de Cátedras de Pedagogía de Universidades Nacionales. Segundo, como colaboradora do 1º Simposio de Enseñanza de la Química e como aluna do Seminário de Politicas de Formacíon, Currículum e Identidades Docentes ministrado pela professora Ms. Flavia Terigi. E finalmente, como apresentadora de comunicação oral no I Congreso Internacional de Enseñanza de las Ciencias y Matemática y II Encuentro Nacional de Enseñanza de la Matemática.O relatório foi escrito a partir da construção de conhecimento na complexidade vivencial das discussões propostas, do referencial teórico utilizado nesta universidade, do profícuo envolvimento com o corpo docente e discente do Departamento de Ciências Exactas y Naturales da Facultad de Humanidades da UNLP, além da imersão realizada em outra cultura, com outra língua e outros enfrentamentos. O engajamento proposto para a realização deste intercâmbio foi essencial na conquista de aprendizagens relacionadas ao Ensino de Química e à Formação de Professores junto a nossos hermanos. A realização de um Doutorado em Educação pressupõe, dentre outras coisas, a superação de lutas concorrenciais por domínio de espaço e de voz com interfaces cada vez mais entrelaçadas.
PUCRS e Newcastle University: uma experiência de internacionalização a partir da construção de uma exposição conjunta entre o Museu de Ciências e Tecnologia e o Great North Museum: Hancock
Authors: Ferraro José Luís Schifino , Simões Pires Melissa Guerra , Shinkai Rosemary Sadami Arai
Published: January 2017

O presente artigo tem como objetivo apresentar a parceria estabelecida entre a Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) e a Newcastle University (NU) para a elaboração conjunta de uma exposição sobre Evolução. Essa aproximação entre o Museu de Ciências e Tecnologia da PUCRS (MCT-PUCRS) e o Great North Museum: Hancok (GNM) possibilitou uma abertura para que ambas universidades estreitassem suas relações e para a elaboração de estratégias e ações para internacionalização. Ao propor um trabalho conjunto – concepção, planejamento e troca de expertises – sobre o tema, optou-se pela utilização das coleções científicas de ambos museus para o ensino da evolução no sentido de promover uma melhor compreensão das modificações climáticas sob uma perspectiva ecomuseológica.
Internacionalização da educação superior: uma análise comparativa documental entre duas instituições privadas e comunitarias da região sul do Brasil
Authors: Guilherme Alexandre Anselmo , Herbertz Dirce Hechler , Morosini Marília Costa
Published: January 2017

Este estudo apresenta a análise documental sobre o processo de internacionalização da Educação Superior em duas universidades privadas e comunitárias, uma do RS e outra do PR, ambas sem fins lucrativos, tendo sua confessionalidade baseada nos princípios Maristas: a PUCRS e a PUCPR. O objetivo foi analisar a importância das relações entre o processo de internacionalização da educação superior e os princípios que fundamentam os Projetos Políticos Institucionais utilizando o referencial teórico de Audy (2006) e Morosini (2006). Trata-se de uma pesquisa qualitativa na medida em que se reflete sobre as políticas internas, os dados apresentados e quantitativa ao trazermos para a discussão dados numéricos das referidas instituições no âmbito nacional e internacional. A fonte de dados foram os documentos institucionais como o Plano Estratégico – PE e o Plano Pedagógico Institucional – PPI; dados do CNPq, CAPES, RUF, The Times e QS. Como resultados desta pesquisa, pode-se apontar para um redimensionamento das organizações institucionais da Educação Superior no que se refere ao desenvolvimento tecnológico, a um projeto global de desenvolvimento humano.
Influence of Oxygen Addition and Substrate Temperature on Textured Growth of Al-Doped ZnO Thin Films Prepared by RF Magnetron Sputtering
Authors: Kuppusami P. , Diesner K. , Sieber I. , Ellmer K.
Published: January 2017

Sputtering of aluminium doped zinc oxide thin films from a ceramic ZnO:Al target requires a controlled addition of oxygen to the sputtering atmosphere in order to obtain films with low resistivity and high transparency. In this paper the influence of the oxygen addition and of the substrate temperature on the structural, morphological and electrical properties of ZnO:Al films is investigated. The oxygen addition leads to a minimum resistivity when the oxygen content during sputtering is 0.2%. This small amount of oxygen not only improves the transparency of the films, it also induces to a significant grain growth as revealed by scanning electron microscopy. A further increase of the oxygen content leads to highly resistive films, due to a complete oxidation of the dopant Al. As expected, higher substrate temperatures from about 373 to 673 K improve the of crystallinity and hence the resistivity. The lowest resistivity achieved was about 1.2.10-3 Ωcm. At still higher temperatures the resistivity increases which seems to be due to an outdiffusion of sodium into the ZnO:Al films from the soda lime glass, compensating part of the donors.
Bulk Versus Surface Magnetic Texture in Thin Films Obtained by Pulsed Laser Deposition
Authors: Sorescu Monica , Grabias A. , Tarabasanu-Mihaila D. , Diamandescu L.
Published: January 2017

In this paper we present a direct comparison between the properties of bulk magnetic systems and those of corresponding thin films obtained by pulsed laser deposition. These are: Fe50Co50, Fe3O4, Fe3O4:Co and Fe2O3:Cr. Using transmission and conversion electron Mössbauer spectroscopy, we present results on the bulk and surface hyperfine magnetic fields, site populations and magnetic texture. Our results support an increase in the hyperfine field values at surfaces, a more pronounced out-of-plane magnetic texture in the films, as well as a perfect transfer of stoichiometry and substitution level from target to substrate materials.
KEBIASAANMAKAN DANBIOLOGI REPRODUKSI IKANMOTAN (Thynnichthys polylepis) DIWADUK KOTOPANJANG, RIAU
Authors: Asyari Asyari , Fatah Khoirul
Published: February 2017

Ikan motan (Thynnichthys polylepis) merupakan jenis ikan yang mempunyai nilai ekonomi yang cukup penting di Kabupaten Kampar. Ikanmotan diWaduk Kotopanjang termasuk jenis ikan yang dominan dan digemarimasyarakat. Penelitian ini untuk mendapatkan data dan informasi mengenai kebiasaan makan dan biologi reproduksi dilakukan pada bulan Agustus sampai Nopember 2009. Penelitian ini dilakukan melalui metode survei dengan pengambilan contoh dilakukan secara purposive sampling. Untuk mengetahui kebiasaan makan digunakan metode Indeks Preponderan, kematangan gonad diamati secara morfologi dan penentuan fekunditas dihitung dengan metodegravimetrik. Hasil penelitian inimenunjukan bahwa ikan motan tergolong jenis ikan herbivora dengan pakan utama makrofita 49,9%, pakan pelengkapnya adalah phytoplankton 22,6% dan detritus 17,4%, dan pakan tambahan terdiri atas protozoa 0,8%, rotifera 0,5%, dan crustaceae 0,4%. Selain itu makanan yang tak teridentifikasi 8,4%. Ikan motan memijah secara bertahap (parsial) dimulai pada bulan Nopember. Fekunditas ikan motan berjumlah antara 25.360-61.198 butir dengan diameter telur pada kisaran antara 0,31-0,90mm, serta indeks kematangan gonad antara 6,65-17,56%. Motan (Thynnichthys polylepis) is one of fish species having the economically important value in Kampar Regency. In Kotopanjang Reservoir motan is a kind of fish which is dominant and it is liked by the people. The objectives of the research were to get data and information of food habit and the biology reproduction such as gonadal maturity, fecundity, and egg diameter has been carried out on August to November 2009. The research is done with the survey method, meanwhile the samples taken by purposive sampling. Food habit can used an index of preponderance method, the gonadal maturity is used by the morphology, meanwhile fecundity is counted by gravimetric. The result of the research shows that motan is belong to a herbivore fish with a mean food macrophyta of 49.9% as a mean food, phytoplankton of 22.6% and detritus of 17.4% as complement food. Meanwhile the addition food such as protozoa of 0.8%, rotiferas of 0.5%and crustaceae of 0.4%. Beside that, the unidentify part is 8.4%. Motan spawning by partial which is started on November. Fecundity of motan shows that the total egg varied between 25,360-61,198 with egg diameter is between 0.31-0.90 mm. Meanwhile index maturity of gonads is between 6.15-17.56 %. Based on the aspects some water quality.
EFISIENSI PEMANFAATANENERGICAHAYAMATAHARIOLEHFITOPLANKTON DALAMPROSES FOTOSINTESISDIWADUKMALAHAYU
Authors: Warsa Andri , Purnomo Kunto
Published: February 2017

Cahaya matahari merupakan sumber energi utama yang menentukan produktivitas suatu ekosistem akuatik. Ketersediaan cahaya akan menentukan kecepatan fotosintesis yang akan menentukan kecepatan pertumbuhan produsen primer. Tujuan penelitian ini adalah untuk mengetahui efisiensi pemanfaatan cahaya matahari oleh fitoplankton di Waduk Malahayu. Penelitian ini dilakukan di Waduk Malahayu, Kabupaten Brebes, Jawa Barat, pada bulan Oktober 2010. Pengamatan produktivitas primer kotor, kelimpahan fitoplankton, intensitas cahaya, dan klorofil-a dilakukan pada dua stasiun yaitu stasiun keramba jaring apung dan dam pada kedalaman 0,5; 2; dan 4 m dengan metode survei berstrata. Pengukuran produktivitas primer kotor dilakukan dengan metode botol gelap dan terang. Hasil penelitian menunjukkan nilai produktivitas primer kotor diWadukMalahayu berkisar 45,6-121,9 mgC/jamdan konsentrasi klorofil-a berkisar 3,7-11,8mg/m3. Kelimpahan individu fitoplankton diWaduk Malahayu berkisar 100,6-112,67 ind./l dengan genera yang dominan adalah Oscillatoria (Cyanophyceae) dan Peridinium (Dinophyceae). Efisiensi penggunaan cahaya matahari oleh fitoplankton di Waduk Malahayu berkisar 0,5-2,7%. Efisiensi cahaya matahari menurun dengan bertambahnya kedalaman air. Sunlight is primary energy resource that determine the productivity of aquatic ecosystem. Its availability will determines the photosynthetic rate and primary producer growth rate. Study in order to know thr effeciency of sunlight uptake by phytoplankton inMalahayu Reservoir, Brebes Regency, Central Java in October 2010. Sampling were for gross primary productivity, phytoplankton abudance, light intensity, and chlorophyll-a carried at two stations, keramba jaring apung and dam and at three water depth, surface, 2 and 4 m with stratified sampling method. Measurement of gross primary productivity was conducted with dark and ight botle method. Gross primary productivity ranged from 45.6-121.9 mgC/hr with chlorophyll-a concentration between 3.7-11.8 mg/m3. Phytoplankton abundance ranged from 10.06-112.67 ind./l with Oscilatoria and Peridinium as dominant genera. Efficiency of sunlight uptake by phytoplankton ranged from 0.5-2.7% and its value decreased along with an increasing water depth.
TEKNIK PENANGKAPAN IKAN SIDAT (Anguilla spp.) DI SUNGAI KETAHUN PROPINSI BENGKULU
Authors: Bahri Syamsul
Published: January 2017

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