bluuebunny/crossref_metadata_2025 huggingface dataset:
Ertugliflozin and Slope of Chronic eGFR
Authors: Cherney David Z.I. , Cosentino Francesco , Dagogo-Jack Samuel , McGuire Darren K. , Pratley Richard , Frederich Robert , Maldonado Mario , Liu Chih-Chin , Liu Jie , Pong Annpey , Cannon Christopher P.
Published: June 2021

Background and objectives

A reduction in the rate of eGFR decline, with preservation of ≥0.75 ml/min per 1.73 m2 per year, has been proposed as a surrogate for kidney disease progression. We report results from prespecified analyses assessing effects of ertugliflozin versus placebo on eGFR slope from the eValuation of ERTugliflozin effIcacy and Safety CardioVascular outcomes (VERTIS CV) trial (NCT01986881).

Design, setting, participants, & measurements

Patients with type 2 diabetes mellitus and established atherosclerotic cardiovascular disease were randomized to placebo, ertugliflozin 5 mg, and ertugliflozin 15 mg (1:1:1). The analyses compared the effect of ertugliflozin (pooled doses, n=5499) versus placebo (n=2747) on eGFR slope per week and per year by random coefficient models. Study periods (weeks 0–6 and weeks 6–52) and total and chronic slopes (week 0 or week 6 to weeks 104, 156, 208, and 260) were modeled separately and by baseline kidney status.

Results

In the overall population, for weeks 0–6, the least squares mean eGFR slopes (ml/min per 1.73 m2 per week [95% confidence interval (95% CI)]) were −0.07 (−0.16 to 0.03) and −0.54 (−0.61 to −0.48) for the placebo and ertugliflozin groups, respectively; the difference was −0.47 (−0.59 to −0.36). During weeks 6–52, least squares mean eGFR slopes (ml/min per 1.73 m2 per year [95% CI]) were −0.12 (−0.70 to 0.46) and 1.62 (1.21 to 2.02) for the placebo and ertugliflozin groups, respectively; the difference was 1.74 (1.03 to 2.45). For weeks 6–156, least squares mean eGFR slopes (ml/min per 1.73 m2 per year [95% CI]) were −1.51 (−1.70 to −1.32) and −0.32 (−0.45 to −0.19) for the placebo and ertugliflozin groups, respectively; the difference was 1.19 (0.95 to 1.42). During weeks 0–156, the placebo-adjusted difference in least squares mean slope was 1.06 (0.85 to 1.27). These findings were consistent by baseline kidney status.

Conclusions

Ertugliflozin has a favorable placebo-adjusted eGFR slope >0.75 ml/min per 1.73 m2 per year, documenting the kidney function preservation underlying the clinical benefits of ertugliflozin on kidney disease progression in patients with type 2 diabetes mellitus and atherosclerotic cardiovascular disease.

Clinical Trial registry name and registration number:

US National Library of Medicine, ClinicalTrials.gov NCT01986881. Date of trial registration: November 13, 2013.
Impact of Student-Run Clinics on Students’ Attitudes Toward People Experiencing Homelessness
Authors: Mercadante Sophia F. , Goldberg Leah A. , Divakaruni V. Laavanya , Erwin Ryan , Savoy Margot , O'Gurek David
Published: June 2021

Introduction: Student-run clinics can supplement medical education by exposing students to diverse clinical scenarios and collaborating with underresourced populations. We examined the impact of volunteering at THRIVE, a student-run bridge clinic located within sheltered housing for individuals with substance use disorder, on students’ attitudes toward people experiencing homelessness (PEH).
Methods: This cohort study analyzed pre- and postsurvey matched responses from nonvolunteer and volunteer first-year medical students utilizing the Health Professional Attitudes Towards the Homeless (HPATHI) tool, totaled into three subcategories: Cynicism, Social Advocacy, and Personal Advocacy. We evaluated the association between change in scores and volunteering utilizing Student t tests and adjusting for participant characteristics using multivariable regression analysis.
Results: We received 106 responses (53% response rate); 58 students (55%) volunteered at the clinic and were mostly female (62%), White (52%), and had previous experience working with PEH (71%). The mean change in Personal Advocacy scores was higher for volunteers compared to nonvolunteers, even when adjusting for respondent characteristics (P=.02). Additionally, students who held a prior advanced degree and/or current enrollment in the master of bioethics program (Higher Education Students) had a positive association with change in Personal Advocacy scores (P=.02).
Conclusion: Volunteering at the THRIVE Clinic appears to impact the Personal Advocacy scores of medical students. This suggests that interacting with PEH early in students’ career may be associated with a commitment to working with this population. However, our study has multiple limitations, including self-selection bias, limited sample size, and unclear permanence of students’ attitudes over time. Further studies of this cohort could help clarify the significance and permanence of volunteering in student-run clinics.
The denatured state of HIV-1 protease under native conditions
Authors: Rösner Heike , Caldarini Martina , Potel Gregory , Malmodin Daniel , Vanoni Maria , Aliverti Alessandro , Broglia Ricardo , Kragelund Birthe , Tiana Guido
Published: June 2021

The denatured state of several proteins has been shown to display
transient structures that are relevant for folding, stability and
aggregation. To detect them by nuclear magnetic resonance (NMR)
spectroscopy, the denatured state must be stabilized by chemical agents
or changes in temperature. This makes the environment different from
that experienced in biologically relevant processes. Using
high-resolution heteronuclear NMR spectroscopy, we have characterized
several denatured states of a monomeric variant of HIV-1 protease
induced by different concentrations of urea, guanidinium chloride and
acetic acid. We have extrapolated the chemical shifts and the relaxation
parameters to the denaturant-free denatured state at native conditions,
showing that they converge to the same values. Subsequently, we
characterized the conformational properties of this biologically
relevant denatured state under native conditions by advanced molecular
dynamics simulations and validated the results by comparison to
experimental data. We show that the denatured state of HIV-1 protease
under native conditions displays rich patterns of transient native and
non-native structures, which could be of relevance to its guidance
through a complex folding process.
Reduction in seizure burden in a child with a A350V IQSEC2 mutation using a Jacuzzi
Authors: Levy Andrew , Levy Nina , Heyman Eli , Schertz Mitchell , Genizi Jacob
Published: June 2021

A child with a A350V IQSEC2 missense mutation resulting in drug
resistant epilepsy stops having seizures when he has a fever. We
demonstrate that raising the body temperature of the child using a
commercial Jacuzzi dramatically reduces his seizures and appears to
improve his social behavioral interactions.
SACRAL DIFFUSE LARGE B-CELL LYMPHOMA PRESENTED AS CAUDA EQUINA SYNDROME. Case report and systemic review.
Authors: Foyaca-Sibat Humberto
Published: June 2021

ABSTRACT: Background: Cauda equina syndrome secondary (CES) to primary
sacral diffuse large B cell lymphoma (DLBCL) is an uncommon condition,
and few cases have been reported in the medical literature. After an
extensive literature review related to these topics, we did not find a
reported case like our patient.
THE ROLE OF FOLK TRADITIONS IN THE SPIRITUAL EXPERIENCE OF THE INFORMATION SOCIETY (PHILOSOPHICAL AND PEDAGOGICAL ASPECTS)
Authors: GARTH MARINA A. , KASATKINA SVETLANA S.
Published: June 2021

In this paper, the authors focus on the development of information and computer technologies in relation to the peculiarities concerning the development of the spiritual experience in society associated with folk culture and folk art. The article examines the concept of “information society”, substantiates the importance of drawing attention to folk culture and applied creativity by the example of the realities in the Russian school education system. The society of post-industrial reality, as a rule, gets acquainted with information to a greater extent in a ready-made format and unlimited scope. This is both an advantage of the information reality and its disadvantage. With the increasing standardization of information resources, there is a lack of creative thinking. Creativity in the modern world with the predominance of ready-made information products is becoming a deficit in the spiritual experience of mankind.
TECHNOLOGIES OF PEDAGOGICAL DESIGN AS A TOOL FOR TRAINING MANAGERS IN GOAL SETTING WHEN PLANNING THE ACTIVITIES OF A PRESCHOOL EDUCATIONAL INSTITUTION
Authors: IVANOVA NATALIA V. , SUKHAREVA MARINA A.
Published: June 2021

The article describes theoretical and practice-oriented aspects of applying pedagogical design technologies while setting the system of goals for a preschool educational institution. Based on the difficulties experienced by managers in activity planning for a preschool educational institution, the authors have substantiated and revealed technological aspects to train managers to set the goals applying the principles of R. Gagné, SMART technology, the author's technique of “5 indicators” as the most accurate and productive tools of pedagogical design that ensure the efficiency of the educational process.
AUTOMATED OPERATIONAL SCHEDULING SYSTEM FOR MULTI-STAGE PRODUCTION: MATHEMATICAL MODEL AND SOFTWARE IMPLEMENTATION
Authors: LOGUNOVA OXANA S. , ARKULIS MIKHAIL B.
Published: June 2021

The purpose of the study is to improve the efficiency of production areas of multi-stage production with the possibility of rational use of equipment capacity and stocks of WIP inventory in the operation conditions of the automated operational scheduling system. Features of the considered problem regarding operative calendar planning are: necessity of processing raw materials at several stages according to the flow chart; an array of the equipment which demands division of work into three periods for each party; availability of planned and unscheduled equipment downtime; necessity to complete set of orders from several suborders; availability of incomplete production in a warehouse; restrictions in order and timing of orders. In the work, the authors construct a mathematical model with the use of multidimensional matroids with structured elements in the construction of free time scale for equipment loading. The research was carried out for a metallurgical plant at the cold strip production site...
POLYSUBJECT IN CONSTRUCTIONS WITH AN ADVERBIAL PARTICIPLES: HISTORY AND THE PRESENT (BASED ON THE MATERIAL OF THE RUSSIAN LANGUAGE)
Authors: VIALSOVA ANNA P.
Published: June 2021

The paper considers polysubject clauses with adverbial participles and their comparison with construction “dative absolute” characteristic of the Old Russian narrative texts. By hagiographic texts and General Internet Corpus of Russian, it has been found that the objective narration of the Old Russian texts required pointing to the subject as it changed according to the scribe’s focus. On the contrary, developing a subjective type of narrative which is focused on the narrator’s modus allows a native speaker to avoid ambiguity of abnormal constructions with adverbial participles and use them as means of actual division of the sentence.
Exponential Growth and New Agendas – a Comprehensive Review of the Arctic Conference Sphere
Authors: Steinveg Beate
Published: June 2021

The Arctic region has attracted the interest of Arctic and non-Arctic states, as well as non-state actors, for decades. Corresponding with the growing attraction towards the region, the number of conferences attending to Arctic issues has expanded. This article provides an historical mapping of the Arctic conference sphere, and demonstrates how the establishment of Arctic conferences has both paralleled central events in Arctic affairs and can be linked to important international developments. Firstly, there is a notable peak conforming with the “second state change” in 2005, brought about by developments opening the Arctic to global concerns: the impacts of climate change and the spread of the socio-economic effects from globalization to the Arctic. Secondly, the expanding number of conferences around 2013 can be seen in relation to the growing interest in the region from non-Arctic states. As such, this article builds the argument for conferences as a central element within the Arctic governance architecture, creating linkages among units in the regime complex. The article devotes particular attention towards the two largest international conferences on Arctic issues – Arctic Frontiers and Arctic Circle Assembly – to illustrate how the necessity for hybrid policy-science-business conferences arose from a more complex governance system, and challenges requiring cross-sectoral, interdisciplinary, and international collaboration.
PENGARUH MODEL BELAJAR PROJECT BASED LEARNING (PJBL) TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN INSTALASI TENAGA LISTRIK SISWA XI DI SMK NEGERI 1 PERCUT SEI TUAN TA.2019/2020
Authors: Sahron Arif , . Baharuddin
Published: June 2021

Abstract This study aims to determine the effect of the project based learning (PJBL) learning model on the learning outcomes of electric power installation in class XI TITL at SMK. This study used a quasi-experimental method with a Posttest Only Control Group Design model. The number of research subjects was 62 students, consisting of 32 students of class XI TITL 1 as the experimental class and 32 students of class XI TITL 2 as the control class. The data collection technique used was a multiple choice written test which had been tested for validity, reliability, difficulty level, and differentiation power. The results showed that the learning outcomes of the project based learning model showed that the students' average score in the experimental class was 77.33 while the control class was 71.16. From the results of the calculation of the hypothesis test, it is obtained tcount 3.261 and ttable is 1.670, then tcount> ttable or 3.261> 1.670, so it can be concluded that the alternative hypothesis (Ha) in this study is accepted while rejecting the null hypothesis (Ho) in other words the learning outcomes of class XI students. Electrical Power Installation Techniques on the competence of understanding the installation and measurement of earth systems with a project based learning (PPA) learning model are higher than student learning outcomes using conventional learning models..Key Words: Project based learning model, learning outcomes AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran project based learning (PJBL) terhadap hasil belajar instalasi tenaga listrik kelas XI TITL di SMK. Penelitian ini menggunakan metode quasi eksperimen dengan model Posttes Only Control Group Design. Jumlah subjek penelitian 62 orang peserta didik, yang terdiri dari 32 peserta didik kelas XI TITL 1 sebagai kelas eksperimen dan 32 peserta didik kelas XI TITL 2 sebagai kelas kontrol. Teknik pengumpulan data yang digunakan adalah tes tertulis berbentuk pilihan ganda yang telah terlebih dahulu diuji Validitas,reliabilitas,tingkat kesukaran, dan daya beda. Hasil penelitian diketahui bahwa hasil belajar model belajar project based learning diperoleh nilai rata-rata siswa pada kelas eksperimen yaitu 77,33 sedangkan kelas kontrol 71,16. Dari hasil perhitungan uji hipotesis diperoleh thitung 3,261 dan ttabel adalah 1,670, maka thitung  > ttabel atau 3,261 > 1,670, sehingga dapat disimpulkan  bahwa hipotesis alternative (Ha) dalam penelitian ini diterima sekaligus menolak hipotesis nihil (Ho) dengan kata lain hasil belajar siswa kelas XI Teknik Instalasi Tenaga Listrik pada kompetensi memahami instalasi dan pengukuran sistem pembumian dengan model belajar project based learning (PJBL) lebih tinggi dari hasil belajar siswa dengan menggunakan model belajar konvensional. Kata Kunci: Model belajar project based learning, hasil belajar
Kantorovich-type operators associated with a variant of Jain operators
Authors: Agratini Octavian , Dogru Ogun
Published: June 2021

"This note focuses on a sequence of linear positive operators of integral
type in the sense of Kantorovich. The construction is based on a class of discrete
operators representing a new variant of Jain operators. By our statements, we
prove that the integral family turns out to be useful in approximating continuous
signals de ned on unbounded intervals. The main tools in obtaining these results
are moduli of smoothness of rst and second order, K-functional and Bohman-
Korovkin criterion."
Sharp inequalities for the rates of convergence of the iterates of some operators which preserve the constants
Authors: Birou Marius Mihai
Published: June 2021

"In this paper we give estimates for the rates of convergence for the
iterates of some positive linear operators which preserve only the constants. We
obtain sharp inequalities when we use both continuous functions and di eren-
tiable functions. We present some optimal results for the Cesaro, Stancu and
Schurer operators."
Barbashin conditions for uniform instability of evolution operators
Authors: Megan Mihail , Boruga Toma Rovana
Published: June 2021

"The aim of the present paper is to give some characterization theorems
of Barbashin type for the uniform exponential instability and uniform polynomial
instability behavior of evolution operators. Also, some examples which illustrate
the connections between the concepts presented are given."
Efectos del uso de drones en la agricultura mexicana: el caso del Valle del Mezquital, Hidalgo
Authors:   , Aranda Bastida Bernardo
Published: June 2021

Este trabajo se enfoca en cómo la tecnología, y en específico los drones, se insertan en el sector agropecuario. Se escogió el estudio de caso del Valle del Mezquital, y en particular tres municipios que son Tlaxcoapan, Tesontepec de Aldama y Francisco I. Madero. Se escogió esta región porque es incipiente el uso de los drones en sus cultivos de estos agricultores, pero principalmente por su importancia agrícola de la región en el estado de Hidalgo. Lo que se analiza a lo largo de esta investigación es cómo los drones, como una innovación tecnológica, se va incorporando a las prácticas agrícolas, y en este sentido, cómo los agricultores van configurando esta tecnología a tal modo que se acople a sus necesidades en esta práctica. En este sentido el objetivo general del trabajo es: Analizar el desplazamiento de la mano de obra por la implementación de los drones en la agricultura mexicana. Y los objetivos particulares son: Explicar cómo la robótica se ha insertado en el campo científico y tecnológico a partir de una revisión histórica; Analizar cómo los drones se han configurado con la sociedad para insertarse en las prácticas agrícolas; Describir el proceso de modernización de la agricultura mexicana y sus repercusiones sociales; Analizar las repercusiones sociales que tiene la implementación de los drones en la agricultura en los municipios de Tlaxcoapan, Tesontepec de Aldama y Francisco I. Madero. La hipótesis que se propone en esta investigación es la siguiente: La implementación de los drones en la agricultura tiene efectos sociales ambivalentes, por un lado, puede ayudar a mejorar la producción del sector de los productores que la adopten, y por otro lado desplaza a otros sectores productivos que no la incorporen, al mismo tiempo afecta a la generación de empleo porque sustituye a la fuerza de trabajo.
La piel morena en el México urbano. Poder y subordinación
Authors:   , Ruiz Cano Edgar Said
Published: June 2021

Este trabajo es esencialmente teórico y su propósito es describir con amplitud la problemática de la desigualdad y la discriminación a partir del color de la piel de los habitantes de México. La disposición por abordar el tema a partir del color de la piel se fundamenta en el desconocimiento social que se tiene acerca del mismo. La percepción de la discriminación en México se vincula a sus componentes de clase, pero pocas veces se entiende el racismo que conlleva ese tipo de contactos. Hablar de color de piel en México sigue siendo un tabú, pues suele negarse la importancia del color de la piel en las interacciones sociales, a grado tal, que también se niega el racismo que conforma la vida diaria. Los datos registrados en decenas de estudios afirman que México es un país donde racismo / clasismo están integrados y son una constante. Estos fenómenos latentes y silenciosos son complejos en su abordaje, por lo que es necesario estudiarlos con profundidad. El punto de arranque fue elemental, la formulación de categorías sociales por color de piel, para poder clasificar posiciones y realidades que asumen las personas en el momento en el que interactúan con sujetos ajenos a sus realidades. Para poder entender de manera más amplia el fenómeno de la diferencia por color de piel, se comenzó con una exploración histórica que dé cuenta de la existencia de estas clasificaciones en distintas etapas del territorio mexicano. Para ello era importante buscar en la hipotética génesis de este fenómeno, que posiblemente inicia en el proceso de conquista de los pueblos mesoamericanos por la corona española. Desde este punto histórico fue posible identificar posiciones sociales que coincidían con las categorías por color de piel, así que ese fue el punto de arranque, para finalmente centrarlo en las épocas recientes, hacer el mismo contraste entre categorías ahora en el México actual.
Nomolas: guías de usabilidad para el desarrollo de interfaces gráficas de visualizaciones para información médica
Authors:   , García-Hernández Mariel
Published: June 2021

A lo largo del tiempo se han desarrollado diversos documentos y normas que establecen la forma en que las interfaces para visualizaciones de información médica deben ser diseñadas, como por ejemplo la norma ISO 9241-11 “Ergonomic requirements for office work with visual display terminal”, la norma IEC TR 61997 “Guidelines for the user interfaces in multimedia equipment for general purpose use”, el ISO/IEC “Information technology - user interface for mobile tools” o la norma ISO 13407 “Human-centred design processes for interactive systems”, en donde se establecen lineamientos técnicos para el diseño de dichos artefactos. Sin embargo, desde el punto de vista del diseño de información y hasta la fecha de publicación de esta tesis, no han sido propuestas guías desde la usabilidad en el diseño mismo, es por eso por lo que la presente tesis doctoral tuvo como objetivo generar guías de usabilidad para el desarrollo de interfaces graficas de visualizaciones de información medica. El desarrollo de las guías de usabilidad propuestas en esta tesis tuvo como base investigaciones de autores como Nielsen, Frascara, Lonsdale & Lonsdale y Cairo, quienes abordan lineamientos como el color, la estructura de la información, el texto, elementos gráficos y el usuario desde la perspectiva del diseño de información y la ergonomía cognitiva. Las guías propuestas en esta tesis doctoral buscan que, al ser implementadas, el diseñador a cargo del desarrollo de interfaces genere artefactos usables, es decir, que sean eficientes (fáciles de leer), efectivos (fáciles de comprender) y satisfactorios (agradables estéticamente) para el usuario que interactuara con estos. Para lograrlo se implementó una prueba de usabilidad, la cual estuvo dividida en dos fases; la primera buscaba validar la composición editorial de las guías y la segunda validar el contenido (en términos de información) de las mismas.
Study Regarding the Analysis of Mobile Defense at the Level of the Land Forces
Authors: Tudorache Paul
Published: June 2021

From analysis of various doctrines belonging to NATO’s armies, some inconsistencies can be identified regarding the use of operational procedures, one of which concerning on mobile defense. Taking into consideration the importance of this defensive task at the level of Land Forces, the study aims to clarify the principles of its use by organic tactical military structures, respectively to identify doctrinal similarities and differences, analyzing in a comparative manner different doctrines of NATO Land Forces. Also, highlighting the operation phasing the operation specific to mobile defense is more than necessary for the present study.
The Social Construction of the “Non-professional Computer Users”: The “Center for the Popularization of Informatics” in Catalonia, Spain (1980s-1990s)
Authors: Meda-Calvet Ignasi
Published: June 2021

The histories of personal computing have been focusing lately on groups of users who saw computing as an exciting new field in activities apparently as different as hardware tinkering, coding or even playing video games. What do we know, however, about the users who did not share these interests and yet ended up using personal computers in their everyday contexts? Based on the study of the Center for the Popularization of Informatics—a Catalan institution that promoted computer technologies among diverse audiences, often unemployed and youth—this article shows how a new and heterogeneous user profile needed to be created: the “non-professional computer users.” With the increasing use of computers in the 1990s, most people employed computer technologies as a means to carry out regular duties and labor tasks performed, in most cases, even before computerization. In addition, the article suggests that computer technologies strengthened more than improved or reshaped the traditional labor processes and working conditions.
Portfolios within the preschool environment
Authors: Trávníčková Petra
Published: June 2021

The academic community has been discussing the options for using portfolios within the education process for a number of years. Studies looking at this phenomenon often focus on a constructivist concept of portfolios where the child is the main agent in creating the document (Sitz & Bartholomew, 2008; Smith et al., 2003). The alternative to this is the positivist concept of the portfolio. The submitted research study is focused on the use of portfolios specifically within the preschool environment. The research’s main objective was to understand how children’s portfolios are used within the education process in preschools and present the children’s perspective on their own portfolios. Adopting a qualitatively-focused research design, the research methods used were content analysis of portfolios, and interviews with children on their document. The research findings show that within the preschool environment, portfolios are used in a number of ways. These ways are directly linked to the teacher’s belief on the importance of portfolios for preschool-age children. A child’s portfolio can be a concept, a tool, a method or also a means. The results also present the children’s original perspective on their own portfolios. This study is based on a part of my completed rigorosum thesis (Trávníčková, 2019).
The temporary return to the homeland in Michael Ondaatje’s Running in the Family
Authors: Joudar Ahmed
Published: June 2021

This study concentrates on memory in Michael Ondaatje’s Running in the Family because it is the foundation for the whole novel. Ondaatje’s attempt creates a relationship with the past by performing all acts of the journey in physical and imaginary performances of listening and reproducing. His attempt depends on his own memory; however, his memory does not coincide with stories he has heard, and the historical documents tend to conflict with each other. In the interior of his travels, Ondaatje reveals the extent of his isolation and the impact of his displacement. As he narrates the stories, he faces difficulties in distinguishing between rumors and lies, in organizing fragments of knowledge, and in explaining challenges tied to his methods of cultural revival. These challenges are met in the non-linear and sometimes stunning text plans which he uses.
Bisphosphonates in Dentistry – State of the Art
Authors: Vučićević Tamara , Živanović Suzana , Papić Miloš , Lukić Aleksandra
Published: June 2021

Bisphosphonates remain the most used and most effective drugs for the treatment of systemic bone diseases followed by bone resorption. Although their side effects in a form of alveolar bone osteonecrosis have been reported, bisphosphonates have a potential of being used in the treatment of the most common oral diseases followed by alveolar bone resorption such as peri-implantitis, periapical lesions, and periodontitis. The aim of this article was to review the most recent research regarding the use of bisphosphonates in the field of dentistry. The results of studies indicate that bisphosphonate use in the treatment of peri-implantitis, periapical lesions, and periodontitis can reduce alveolar bone resorption and contribute to bone preservation. However, the most beneficial way of their application in the treatment of these oral diseases remain to be determined.
Light Catcher
Authors: Durden Mark
Published: June 2021

Among his remarkable performance-based short films made in the garden of his family home, two films show the artist holding a mirror to both catch and reflect sunlight back to the camera and viewer. Such performances provide a fitting allegory for his relationship to the medium of photography. As a photographer Peter Finnemore is someone who catches and plays with light.
Light is key to the pictures made in his home place in rural mid Wales, Gwendraeth House. The photographs relay the intimacy he has with his childhood home, which has been in his family for generations. Finnemore has been photographing his home for thirty years and his pictures are full of hints and suggestions, traces of those who live and lived there. With people’s passing, he is now its sole occupant and the house has become more and more a portrait of his own imagining, his dream space.
Finnemore photographs feelingly and describes his home as “a dreaming centre to divine and survey the spaces between darkness and stars”. Working with black and white film and the chemical-based printing process his richly toned prints explore the opposition and gradations between non-light and light, negative and positive, with all their symbolic implications. Like film, the house and its rooms are seen as receptive and responsive spaces. In Dream Traces a partly decorated wall above a bed is animated both by the gestural traces of darker paint upon it and lighter rectangular areas where posters and pictures were once attached. The wall is not blank but a field of different energy forces, the slow photographic effect of the darkening of the wall around the absent pictures against the more immediate brushmarks of house paint at its edges. The wall is also suggestive of an awakening state, the sense of something not fully coming into consciousness. This is in contrast to the relative order and geometry introduced by the wooden bars of the bedstead and the clarity of the singing and piercing detail of the white dot at the centre of an eye, painted on glass. This Greek mati, used to ward off evil, becomes the focal point of this picture and cue to many objects and elements in his pictures that are felt to be imbued with energies and powers beyond their material form.
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UJI AKTIVITAS ANALGESIK GEL BULUNG (Gracilaria sp.) TERHADAP MENCIT PUTIH JANTAN (Mus musculus)
Authors: Witadnyana Yan Degus Winten , Giri Gede Sugiartha , Anata I Made Ari , Salim Mohammad Fajar Hadi , Karmayani Ni Wayan , Agustina Ni Putu Dian , Perdana Pande Gede Raditya Wira , Wijayanti Ni Putu Ayu Dewi
Published: June 2021

UJI AKTIVITAS ANALGESIK GEL BULUNG (Gracilaria sp.) TERHADAP MENCIT PUTIH JANTAN (Mus musculus). Penelitian ini dimaksudkan untuk mengetahui aktivitas analgesik gel bulung (Gracilaria sp.) sebagai alternatif obat analgesik. Evaluasi efek analgesik gel bulung pada hewan uji adalah dengan menghitung lama waktu bertahan mencit pada hotplate setelah diberi perlakuan uji, kontrol positif dan kontrol negatif pada hewan uji. Penelitian ini hanya meneliti satu variabel bebas saja yaitu variasi dosis obat gel fraksi bulung sangu terhadap variabel tergantungnya yaitu daya analgetik pada mencit yang berupa persen aktivitas analgetik dari gel fraksi bulung sangu. Kelompok uji (gel fraksi bulung sangu) dengan konsentrasi fraksi 1%; 1,25%; 1,5%. Dapat disimpulkan pada gel Voltaren® akan memberikan efek analgesik pada menit ke-30 setelah pemberian dan gel bulung akan memberikan efek analgesik pada menit ke-30 sampai 90 setelah pemberian.
Enfarte da Artéria de Percheron: Caso Clínico
Authors: Pinheiro Hugo Celso , Bela Margarida , Magalhães Nuno , Mesquita Mari
Published: June 2021

A artéria de Percheron (AOP) é uma variante normal que irriga o tálamo. Os enfartes da AOP podem originar um espectro alargado de apresentações clínicas invulgares. O seu diagnóstico é dificultado pela conjunção de dois factores: falta de sensibilidade da tomografia computadorizada e falta de conhecimento desta entidade motivada pela sua raridade. Descrevemos o caso de uma doente com coma por enfarte da AOP. Pretendemos salientar a importância de considerar esta entidade no diagnóstico diferencial de doentes com défices neurológicos vagos de origem indeterminada. Reforçamos ainda a necessidade de baixar o limiar para a realização de ressonância magnética com o objetivo de facilitar o diagnóstico e diminuir a morbilidade associada.
Peritonite Esclerosante Encapsulante: Uma Doença Rara e Insidiosa mas Potencialmente Fatal
Authors: Reis Carreira Nuno , Sousa Gonçalves Catarina , Wahnon Alexandra , Teixeira Silva Marisa
Published: June 2021

A peritonite esclerosante encapsulante é uma doença rara e insidiosa associada a espessamento e fibrose peritoneal, afectando sobretudo doentes com historial de diálise peritoneal. Uma evolução clínica desfavorável com encarceramento de ansas intestinais culmina numa taxa de mortalidade de 25%-55%. Apresenta-se homem de 47 anos, com antecedentes de doença renal crónica previamente sob diálise peritoneal. Avaliado no serviço de urgência por febre, anorexia e ascite com 1 semana de evolução. Laboratorialmente referia-se elevação dos parâmetros inflamatórios. Radiologicamente documentou-se ascite não pura septada, com espessamento do peritoneu e compressão de ansas intestinais. A paracentese foi compatível com ascite hemática exsudativa. Após início de tamoxifeno e corticoterapia, verificou-se melhoria clínica significativa e redução da ascite e do espessamento peritoneal em tomografia computorizada abdominal. Neste trabalho descreve-se uma complicação rara e potencialmente fatal da diálise peritoneal. Visto cursar com manifestações e achados inespecíficos, exige uma avaliação clínica meticulosa em casos suspeitos.
Patologia Oncológica e Hospitalização Domiciliária: Um Novo Horizonte?
Authors: Lameiras Xete Dora
Published: June 2021

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Sarcoma de Kaposi: Um Caso Clínico de Exuberantes e Múltiplas Lesões Cutâneas como Forma de Apresentação de SIDA
Authors: Marques Marto Daniela , Batista Simões Pedro , Maltez Fernando , Duarte Oliveira Sónia
Published: June 2021

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Ventilação Não-Invasiva na Falência Respiratória Aguda
Authors: Costa Bárbara , Amaral Ricardo , Sá Vieira Miguel , Maia José Miguel , Barros Nelson , Esteves Francisco
Published: June 2021

Introdução: A ventilação não invasiva (VNI) é uma opção válida, ainda que não consensual, no tratamento de doentes com falência respiratória aguda. O presente artigo tem o objetivo de identificar fatores preditores de resposta à VNI neste grupo de doentes.

Métodos: Estudo retrospectivo longitudinal que incluiu todos os doentes admitidos numa unidade de cuidados intensivos nos anos 2016 e 2017, nos quais a VNI foi utilizada no decurso de falência respiratória aguda de novo (PaO2/ FiO2 < 200). Foram incluídos doentes com pneumonia adquirida na comunidade (PAC) e síndrome da dificuldade respiratória aguda (SDRA) e comparados doentes com resposta à VNI com os não respondedores.

Resultados: Entre 2016 e 2017, 83 doentes com falência respiratória aguda de novo foram tratados com VNI. Destes, 50 (60%) foram tratados com sucesso. A causa mais comum de falência respiratória foi a PAC, que registou valores de resposta à VNI de 70%. Doentes respondedores à terapêutica de ventilação não invasiva apresentaram scores de gravidade (APACHE 2; SAPS 2; SOFA) inferiores à admissão (17,5; 37,5; 6 vs 22; 48; 9, p=0,014, p<0,01 e p<0,01, respetivamente). Os não respondedores apresentaram valores significativamente inferiores de pH arterial (7,35 vs 7,42, p<0,01), rácio PaO2/FiO2 (118 vs 145, p=0,03), e valores significativamente superiores de lactato sérico (2,2 vs 1,46, p<0,01) assim como maior necessidade de suporte vasopressor (51,5% vs 30%, p=0,04). No que diz respeito a dados gasimétricos após início de VNI, o rácio PaO2/FiO2 registou um aumento superior e estatisticamente significativo no grupo de doentes com resposta à VNI (+53, p<0,01 vs +14, p=0,09).

Conclusão: A VNI foi eficaz como estratégia ventilatória em 60% dos doentes com falência respiratória aguda. Os doentes que aparentam ter maior probabilidade de resposta à introdução da VNI são: doentes com PAC, com ou sem SDRA moderado (em detrimento do SDRA severo), doentes sem acidemia respiratória e doentes sem hiperlactacidemia e/ou necessidade de suporte vasopressor. A melhoria do ratio PaO2/FiO2 após as primeiras duas horas de VNI parece ser um bom preditor de sucesso.
Espectro Clínico dos Autoanticorpos TH/TO e NOR90 na Esclerose Sistémica
Authors: Cravo Márcia , Mendonça Teresa , Farinha Fátima
Published: June 2021

Introdução: A esclerose sistémica é uma doença autoimune com amplo espectro clínico. Os autoanticorpos podem indiciar sintomas, diagnósticos e orientar para o tratamento mais adequado. A relevância da pesquisa do anti-Th/To e anti-NOR 90 é menos conhecida. O objetivo foi avaliar as principais manifestações clínicas e diagnósticos etiológicos associados aos anticorpos Th/To e NOR 90.

Material e Métodos: Estudo observacional retrospetivo, envolvendo 61 doentes em seguimento na consulta externa de doenças autoimunes com os anticorpos Th/To ou NOR90 positivos em centro único, entre 2018 e 2020. Foram excluídos os doentes sem informação disponível. Os dados demográficos, manifestações clínicas e diagnósticos foram analisados com recurso a informação dos processos informáticos.

Resultados: Na amostra o género feminino foi o mais prevalente. Verificou-se envolvimento cutâneo, articular, cardiopulmonar e gastrointestinal, sem atingimento renal associado a nenhum dos autoanticorpos. Em ambos os grupos foi estabelecido diagnóstico de esclerose sistémica em 40% dos casos. Não se identificaram outros autoanticorpos concomitantes em 53% e 50% dos doentes com Th/To e NOR90, respetivamente.

Discussão e Conclusão: Este estudo demonstrou envolvimento similar em ambos os autoanticorpos com atingimento cutâneo e articular frequentes, maior envolvimento cardiopulmonar nos doentes com anti-Th/To e gastrointestinal no grupo com anti-NOR90. Apesar de ambos se terem associado à esclerose sistémica numa percentagem não desprezível de doentes, em aproximadamente metade dos casos encontravam-se isolados, sem concomitância com outros autoanticorpos relacionados com esta doença, indiciando a relevância da sua pesquisa ativa aquando a suspeita clínica de esclerose sistémica com intuito diagnóstico.
Strategi Pemasaran Jasa Angkutan Udara PT. Merpati Nusantara Airline
Authors: Lukiana Lukiana , Yarlina Lita
Published: June 2021

The more competitive competition has demanded companies to defend and set up a marketing strategy that is appropriate and meet the conditions faced by PT Merpati Nusantara Airline. With the current number of airline companies, PT Merpati Nusantara Airline needs appropriate marketing strategy formulation that is able to create balance between internal and external environment. This study is conducted to figure out the strength, weakness and opportunity owned by the company as well as the challenge. Therefore, as a sample in this study, the author takes opinions from PT Merpati Nusantara Airline customers in Sultan Hasanuddin Airport Makassar. This study uses SWOT analysis approach method and strategic alternative matrix used to form strategic factors assessed to be able to describe clearly the opportunity and external threats as well as the strengths and weaknesses owned by PT Merpati Nusantara Airline. From the calculation of figure and rating, it shows that PT Merpati Nusantara Airline is located in the Quadrant II (-0.15:0.7) meaning that it faces a big market opportunity yet on the other hand it faces some problems and internal weaknesses. The focus of the strategy is conducted by minimizing internal problems, in order to get a better market opportunity.Persaingan yang semakin kompetitif menuntut perusahaan untuk bertahan dan menciptakan suatu strategi pemasaran yang tepat, sesuai dengan kondisi yang dihadapi oleh perusahaan PT. Merpati Nusantara Airline, yang membutuhkan strategi yang tepat dan sesuai yang dapat menyeimbangkan antara lingkungan internal dengan eksternal. Manfaat kajian ini adalah untuk mengetahui kekuatan, kelemahan dan peluang yang dimiliki oleh perusahaan serta tantangan yang harus dihadapi oleh perusahaan penerbangan PT.Merpati Nusantara Airline. , sebagai sampel dalam pengkajian ini adalah opini penumpang maskapai Merpati yang beroperasi di Bandar Udara Sultan Hasanuddin – Makassar. Metodologi yang digunakan menggunaan pendekatan analisis SWOT dan matriks alternatif strategi dipakai untuk menyusun faktor-faktor strategis yang dinilai dan dapat menggambarkan secara jelas bagaimana peluang dan ancaman eksternal yang dengan kekuatan dan kelemahan yang dimilik PT.Merpati Nusantara Airline. Dari hasil perhitungan pembobotan dan rating bahwa posisi PT. Merpati Nusantara Airline terletak pada kuadaran II (-0,15 : 0,7) yaitu menghadapi peluang pasar yang sangat besar tetapi, di lain pihak, menghadapi beberapa kendala atau kelemahan internal. Fokus strategi yang dilakukan adalah meminimalkan masalah-masalah internal, sehingga dapat merebut peluang pasar yang lebih baik.
Evaluasi Keamanan Penumpang Di Bandara Ngurah Rai Bali
Authors: Lumban Batu Harry Yanto
Published: June 2021

The air service growth each year has been increasing. Therefore, the airport security has to be well-conducted by the airport authorities and related institutions as mandated by the Government Regulation Number 3 of 2001 on the Security and Safety of Aviation, in which every person and object must pass through the screening process. The occurrence of unlawful acts during the security screening process will create disturbance for the aviation security and safety. In the study on the passengers’ screening process, there are three factors that are analyzed which are security personnel, security facility/tool and security procedures that comply with the applicable standard conditions. Accordingly it need to evaluate pasengger security at Bali Ngurah Rai Airport.Pertumbuhan jasa angkutan udara dari tahun ke tahun semakin meningkat, oleh karena itu, keamanan di bandar udara harus mampu diciptakan oleh penyelenggara bandar udara serta instansi terkait lainnya sesuai dengan Peraturan Pemerintah Nomor 3 Tahun 2001 tentang Keamanan dan Keselamatan Penerbangan, dimana setiap orang, barang harus melalui pemeriksaan keamanan. Adanya tindakan melawan hukum dalam pemeriksaan penumpang di bandar udara memberikan dampak yang mengganggu bagi keamanan dan keselamatan penerbangan. Dalam penelitian mengenai pemeriksaan penumpang dianalisis dari 3 faktor yaitu personil pengamanan, fasilitas/peralatan pengamanan dan prosedur yang memenuhi ketentuan/ persyaratan standar yang berlaku. Berdasarkan hal tersebut, perlu dilakukan evaluasi terhadap keamanan penumpang di bandar udara Ngurah Rai Bali.
Kebutuhan Pengembangan dan Keterampilan Khusus Personil dalam Bidang Penerbangan Indonesia
Authors: Supriyadi Yaddy , Abdullah Rusdi
Published: June 2021

Mitigation action towards aviation occurrence in Indonesia, according to number of aviation accident of the National Transport Safety Commitee, have not been showing a significant results. It can be caused by two things. First, the continuous development of aviation knowledge and technology. Second, the gaps between knowledge and skills that acquired during training phases and those required in the working environment This research is aimed to identify these gaps. The lack of understanding of Air Traffic Controllers on the concept of separation and how to implement it, minimum English speaking skills, and no training on RNA V and RNP are findings related to training solution. Whilst the malfunction of communication and monitoring devices, and no callibration to those devices are findings related to non-training solution.

Pemecahan permasalahan kecelakaan penerbangan di Indonesia, berdasarkan data jumlah kecelakaan pesawat dari Komisi Nasional Keselamatan Transportasi, dapat dikatakan belum optimal. Masalah tersebut dapat dilihat dari dua hal, yaitu perkembangan ilmu pengetahuan dan teknologi penerbangan maupun kesenjangan yang terjadi antara kebutuhan pengetahuan dan keterampilan personil di lapangan dengan pengetahuan dan keterampilan yang diberikan pada masa pendidikan dan pelatihan. Penelitian ini dimaksudkan untuk mengidentifikasi kesenjangan tersebut. Kurangnya pemahaman personil Pemandu Lalu Lintas Udara terhadap konsep pemberian separation dan implementasinya, kurangnya keterampilan bahasa Inggris dan belum terprogramnya program pelatihan RNAV dan RNP merupakan temuan yang bersifat pelatihan. Sementara tidak optimalnya fungsi peralatan komunikasi dan monitoring bahkan tidak dapat dioperasikannya peralatan monitoring serta tidak adanya program kalibrasi terhadap peralatan tersebut merupakan hasil temuan yang bersifat non-pelatihan dari penelitian ini.
Metode Pengukuran Peralatan Localizer di Bandar Udara (Studi Kasus Bandar Udara Sam Ratulangi-Manado)
Authors: Fatonah Feti
Published: June 2021

In accordance with the Rules of DGCA number: 83 2005, about the testing procedures on the ground (ground inspection) equipment electronics and electrical facilities, the cost of all existing facilities at the airport including ILS localizer testing should be carried out on land with parameters determined in order to maintain the operational performance of equipment in accordance with the standards and operational requirements that have been set. And in accordance with ICAO Annex 10 Document 8071, then to determine the performance of the localizer equipment mandatory calibration flight. This calibration flight periodically for localizer equipment provisions must be implemented four months in which the airport in cooperation with the Ministry of Transportation calibration.Sesuai dengan Peraturan dari Direktorat Jenderal Perhubungan Udara nomor : 83 tahun 2005, tentang prosedur pengujian di darat ( ground inspection ) peralatan fasilitas elektronika dan listrik penerbangan maka semua fasilitas yang ada di Bandara termasuk ILS, Localizer harus dilaksanakan pengujian di darat dengan parameter yang telah ditentukan guna mempertahankan kinerja operasional peralatan sesuai dengan standard dan persyaratan operasional yang telah ditetapkan. Dan sesuai dengan annex 10 Document 8071 ICAO, maka untuk mengetahui kinerja dari peralatan localizer maka wajib dilakukan penerbangan kalibrasi. Penerbangan kalibrasi ini berkala untuk peralatan localizer ketentuannya harus dilaksanakan 4 bulan sekali dimana pihak Bandar udara bekerja sama dengan Balai kalibrasi Kementerian Perhubungan.