bluuebunny/crossref_metadata_2025 huggingface dataset:
La inclusión educativa en números: Zona -: Chimborazo, Cotopaxi, Pastaza y Tungurahua
Authors:   Universidad del Azuay, Toral-Tenorio Juanita Soraya , Proaño-Arias Elida Margarita ,   Universidad del Azuay, Córdova González María Lorena ,   Universidad del Azuay, Guevara-Toledo Carlos ,   Universidad del Azuay, Huiracocha-Tutivén Karina ,   Universidad del Azuay, Fajardo-Chunchi Daniel Humberto ,   Universidad del Azuay, Santander-Santander Luis Alberto ,   Universidad del Azuay, Berrezueta-Pesántez Elizabeth Cecilia ,   Universidad del Azuay, Nieto-Trelles Andrea Verónica ,   Universidad del Azuay, Cabrera-Sinchi Freddy Rómulo ,   Universidad del Azuay, Pauta-Narváez Mayra Elizabeth ,   Universidad del Azuay, Ochoa-Guerrero María Eugenia ,   Universidad del Azuay
Published: January 2023

El desarrollo del proyecto, en gran medida, se posibilitó gracias al convenio de cooperación establecido entre la Universidad del Azuay y la Secretaría Técnica de Discapacidades del Ecuador, SETEDIS, organismo que, entre otras acciones facilitó la colaboración del Ministerio de Educación, y posibilitó el desarrollo de las actividades planificadas tanto a nivel local como nacional. La investigación fue realizada en el marco de la primera Maestría de Educación Básica Inclusiva, e involucró a los 26 maestrantes a través del desarrollo de sus respectivas tesis de grado, así como a 11 profesores del programa. Este selecto grupo laboró con gran entusiasmo y compromiso social por el lapso aproximado de 9 meses y se desplazó, en estricto cumplimiento de los objetivos trazados, a diferentes zonas de la geografía patria. 214 páginas ISBN: 978-9942-822-03-1 e-ISBN: 978-9942-822-11-6
Guía UDA 0
Authors:   Universidad del Azuay, Proaño-Arias Elida Margarita , Tripaldi-Cappelleti Piercósimo ,   Universidad del Azuay, Calderón-Salazar Mery Alexandra ,   Universidad del Azuay, Pérez-Fajardo Inés Cristina ,   Universidad del Azuay, Montero-Arévalo Mariuxi Alexandra ,   Universidad del Azuay, Montero-Arévalo Juana Catalina ,   Universidad del Azuay
Published: January 2023

UDA 0 constituye una prueba de cribado del desarrollo infantil. Este trabajo es un gran aporte en las áreas de educación y psicología, pues supera la creencia de que construir, adaptar, validar o estandarizar instrumentos de diagnóstico en nuestro medio es algo que no podemos hacer, que requiere recursos fuera de nuestro alcance. Por ello, con gran satisfacción he leído esta obra que parte de las evaluaciones del desarrollo que se utilizan en el Ecuador para construir y validar una prueba para nuestra población. La obra incluye un sólido marco teórico que sustenta la prueba UDA 0 desde sus bases neurofisiológicas, neuroanatómicas y del desarrollo. Reconozco la trayectoria y el trabajo de todos los autores quienes plasman su calidad académica en esta obra que espero sea utilizada al máximo y la disfruten. Finalmente, confío que los que hacemos la Universidad del Azuay podamos seguir trabajando en la construcción de conocimiento dentro del área del neurodesarrollo infantil. 106 páginas ISBN: 978-9942-822-26-0 e-ISBN: 978-9942-822-28-4
Pemberian Imunisasi Dasar Lengkap Pada Bayi
Authors: Arianggara Andi Wilda , Pratiwi Febrianty Hany , Tarigan Renny Adelia
Published: January 2023

Pendahuluan: Imunisasi dasar merupakan salah satu program dari pemerintah yang diberikan kepada bayi dan balita yang bermanfaat untuk melindungi kesehatan dan meningkatkan daya tahan tubuh. Tujuan: Penelitian ini bertujuan untuk memperoleh informasi lebih lanjut mengenai perilaku ibu mengenai pemberian imunisasi primer di wilayah kerja Puskesmas Tompobulu Kabupaten Gowa. Metode: Penelitian ini menggunakan metode kualitatif (berdasarkan kondisi alam) dengan pendekatan fenomenologi (berdasarkan pengalaman hidup). Informan inti dalam penelitian ini adalah ibu yang memiliki bayi 9-12 bulan dan imunisasi yang tidak lengkap sebayak 7 orang dan juga informan kunci yaitu ahli hukum imunisasi dan tokoh masyarakat. Pengumpulan data dilakukan dengan memperdalam wawancara menggunakan pedoman wawancara. Hasil: Hasil penelitian menunjukkan bahwa pengetahuan ibu masih kurang tentang imunisasi dasar, ibu memiliki sikap negatif terhadap pemberian imunisasi dasar, juga tindakan/praktik ibu yang buruk terhadap imunisasi dasar. Kesimpulan: Peningkatan edukasi dan promosi terkait imunisasi penting bagi ibu yang memiliki balita.
Pengaruh Pendidikan Kesehatan dengan Booklet Diet Hemodialisa (BookET Lisa) Terhadap Tingkat Pengetahuan dan Sikap Pasien Hemodialisa di RSUD dr. RM. Pratomo Bagansiapiapi
Authors: Ezdha Awaliyah Ulfah Ayudytha , Hamid Abdurrahman , Fitri Dwi Elka , Anggreini Silvia Nora , Julianti Elli Elfiza
Published: January 2023

Pendahuluan: Salah satu terapi terhadap penderita gagal ginjal kronik yaitu hemodialisis. Hemodialisis bertujuan untuk mengeliminasi sisa-sisa produk metabolisme atau protein dan sebagai koreksi gangguan keseimbangan cairan dan elektrolit. Tindakan dialisis ini juga dapat menyebabkan komplikasi, diantaranya yaitu mempengaruhi status gizi pasien yang menjalani hemodialisa. Beberapa pasien mengalami kesulitan dalam pengelolaan asupan nutrisi, namun mereka tidak mendapatkan pemahaman tentang bagaimana strategi yang dapat membantu dalam pengelolaan diet nutrisi sehingga strategi yang perlu dilakukan adalah pemberian pendidikan kesehatan menggunakan booklet mengenai diet nutrisi untuk pasien hemodialisis. Tujuan: Tujuan penelitian ini adalah untuk mengetahui pengaruh edukasi kesehatan dengan media booklet tentang diet nutrisi terhadap pengetahuan dan sikap pasien hemodialisa di RSUD DR. RM. Pratomo Bagansiapiapi. Metode: Penelitian ini merupakan penelitian kuantitatif dengan menggunakan desain penelitian pre eksperimen design berupa rancangan “pretest-posttest with one group design”. Jumlah Responden pada penelitian ini adalah 27 responden. Hasil: Berdasarkan hasil dari uji T-test dependent diperoleh p value (o,000) untuk variable pengetahuan dan sikap lebih kecil dari 0,05. Kesimpulan: Penelitian ini menunjukkan adanya perbedaan yang signifikan pada pengetahuan dan sikap sebelum dan sesudah diberikan edukasi kesehatan dengan media booklet tentang diet nutrisi pasien hemodialisa.
SİYASİ PARTİLERİN SEÇİM BEYANNAMELERİNİN KARŞILAŞTIRMALI METİN ANALİZİ: 1 KASIM 2015 VE 24 HAZİRAN 2018 MİLLETVEKİLİ GENEL SEÇİMLERİ ÖRNEĞİ
Authors: KAN Muhammed Enes
Published: January 2023

Bu çalışmanın amacı siyasi partilerin 1 Kasım 2015 Milletvekili Genel Seçimleri ve 24 Haziran 2018 Milletvekili Genel Seçimleri öncesinde yayınlamış oldukları seçim beyannamelerinin incelenerek, bu süreç zarfında partilerin söylemleri ve vurgu yaptıkları temel konuların tespit edilmesi ve değişimlerin ortaya konulmasıdır. Özellikle bu iki seçim arasında meydana gelen önemli siyasal olaylar ve bunların meydana getirdiği siyasal iklim bu çalışmanın temel motivasyon kaynağı olmuş, bu üç yıllık sürecin partilerin söylemlerine ve vurgu yaptığı konulara nasıl etki ettiği seçim beyannameleri üzerinden araştırılmıştır. Araştırma söz konusu her iki seçimde de mecliste yer almaya hak kazanan, AKP, CHP, MHP ve HDP’nin bu seçimler öncesi sundukları seçim beyannameleri ile sınırlandırılmıştır. Doküman incelmesi yöntemiyle elde edilen veriler NVIVO 12 paket programından da faydalanılarak metin analizi yöntemiyle analiz edilmiştir. Çalışma sonucunda AKP ve CHP’nin her iki seçim beyannamesinde de toplumun ortak konularına vurgu yaptığı, diğer bir ifadeyle seçim beyannamelerindeki vurgularının çok fazla değişmediği, MHP’nin seçim beyannamelerinde partinin milliyetçi ideolojisini yansıtan kelimelerin her iki seçim beyannamesinde de ön plana çıkmasına rağmen 24 Haziran 2018 Milletvekili Genel Seçimleri için hazırlanan beyannamede cumhurbaşkanlığı hükümet sistemini açıklama çabasının bazı kelimeleri ön plana çıkardığı, MHP’ye benzer bir şekilde HDP’nin de iki seçim döneminde kullandığı kelimelerin sıklığında değişimler meydana geldiği ve özellikle 24 Haziran 2018 Milletvekili Genel Seçimleri beyannamesinde toplumun ortak sorunlarına yönelik vurguların yoğunlaştığı tespit edilmiştir.
AKADEMİSYENLERİN MESLEK AŞKI VE İŞ DOYUMU DÜZEYLERİ ARASINDAKİ İLİŞKİDE PSİKOLOJİK SERMAYENİN ARACILIK ROLÜ
Authors: ÖGÜL Tülin , ÖZER Pınar
Published: January 2023

Bu çalışmada, meslek aşkı varlığı ve meslek aşkı arayışının iş doyumu ile ilişkisinde psikolojik sermayenin aracılık etkisi incelenmiştir. Araştırmanın örneklemini, Türkiye’deki devlet ve vakıf üniversitelerinde görev yapmakta olan, yönetim ve organizasyon bilim alanında araştırma yapan, görev yaptığı bölüm ağırlıklı işletme, anabilim dalı ise yönetim ve organizasyon olan akademisyenler (N=148) oluşturmaktadır. Araştırma verilerinin elde edilmesinde, survey yöntemi ve yazılı soru sorma tekniği kullanılmıştır. Araştırmanın amacı akademisyenlerin meslek aşkı varlığı ve meslek aşkı arayışının iş doyumuna etkisinde psikolojik sermayenin aracılık rolünün bulunup bulunmadığını sorgulamaktır. Yapılan hipotez testleri sonucunda; meslek aşkı varlığının iş doyumuna etkisinde psikolojik sermayenin tam aracılık rolünün bulunduğu, meslek aşkı arayışının iş doyumuna etkisinde psikolojik sermayenin kısmi aracılık rolünün bulunduğu belirlenmiştir. Bu araştırmanın bulguları, iş doyumunun artırılmasında psikolojik sermayenin önemli bir değişken olduğunu göstermekte, örgütlerde psikolojik sermayenin geliştirilmesine vurgu yapmaktadır. Bu araştırma, meslek aşkı varlığı ile meslek aşkı arayışının iş doyumuna etkisinde psikolojik sermayenin aracılık etkisini inceleyen ilk çalışmadır ve araştırma bu yönüyle özgünlük taşımaktadır.
FASON ÜRETİM YAPAN TEKSTİL İŞLETMELERİNDE İNSAN KAYNAKLARI YÖNETİMİNDE EĞİLİMLER
Authors: CİNEL Mehmet Ozan , KARAMAN Güven
Published: January 2023

Endüstri 4.0 uygulamalarıyla üretimin otomasyonlaşması tedarik, üretim ve pazarlama maliyetlerini azaltırken verimliliği ve kaliteyi öne çıkarmıştır. İleri teknolojiyi üretim sürecine uyarlayamamış işletmelerde ise emek yoğundur. Bu durum işletmelerin rekabet gücünü dolayısıyla ülkelerin kalkınmışlık düzeyini etkilemektedir. Türkiye, ileri teknolojiyi yakalayabilme, bölgeler arası ekonomik dengeyi sağlamak üzere kalkınma bölgeleri ve bölgesel teşvik sistemleri oluşturmuştur. TR 90 Doğu Karadeniz Bölgesinde emek yoğun sektörler: tekstil, mobilya vb. teşvik edilmektedir. İŞKUR kayıtlarına göre bölge illerinden Ordu ve Giresun illeri, fason üretim yapan tekstil işletmeleri, çalışan sayıları ve işgücü hareketliliğiyle dikkat çekmektedir. Araştırmanın amacı bu işletmelerde insan kaynaklarının yönetimine yönelik eğilimlerin araştırılması, yörenin en önemli geçim kaynaklarından biri olan fındığın hasat döneminde yaşanan işten ayrılmaların bu işletmelerin faaliyetlerine etkilerinin irdelenmesi ve öneriler sunulmasıdır. Veriler, anket formuyla ve görüşme yöntemiyle toplanmıştır. Araştırma sonucunda, bu işletmelerde çalışan memnuniyetinin artırılması ve aidiyet duygusunun geliştirilmesi gerektiği, işletme faaliyetlerinin fındık hasat döneminde işten ayrılma, yıllık veya sıhhi izinlerin artmasına bağlı olarak olumsuz etkilendiği belirlenmiştir.
Pengaruh Content Marketing, Sales Promotion, Personal Selling Dan Brand Image Terhadap Minat Beli Pada CV Laditri Karya
Authors: Hardiyanah Tia , Hidayati Rini , Nasution Ananta Hagabean , Muslikh Muslikh , Marhamah Siti
Published: January 2023

Penelitian ini dilakukan dengan tujuan untuk menguji pengaruh content marketing, sales promotion, personal selling dan brand image terhadap minat beli pada CV Laditri Karya. Sampel yang digunakan dalam penelitian sebanyak 100 pengikut akun Instagram @laditrikarya dengan metode survei berupa instrumen kuesioner yang diolah menggunakan SPSS 24. Hasil penelitian ini menyatakan bahwa : (1) content marketing tidak berpengaruh signifikan terhadap minat beli. (2) sales promotion berpengaruh positif dan signifikan terhadap minat beli. (3) personal selling tidak berpengaruh signifikan terhadap minat beli. (4) brand image berpengaruh positif dan signifikan terhadap minat beli. (5) content marketing, sales promotion, personal selling dan brand image berpengaruh terhadap minat beli secara simultan
Pengaruh Pajak Dan Kepemilikan Asing Terhadap Keputusan Perusahaan Untuk Melakukan Transfer Pricing (Studi Empiris Perusahaan Manufaktur yang Terdaftar BEI Tahun 2016-2020)
Authors: Syahbana Fikra Nur , Madjid Suhirman , Mahmud Amir , Lapae Kanaya
Published: January 2023

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pajak dan kepemilikan asing terhadap keputusan perusahaan menggunakan transfer pricing. Data sekunder digunakan dalam penelitian ini. Perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia periode 2016-2020 digunakan sebagai sampel penelitian, dengan jumlah 28 perusahaan diperoleh melalui metode purposive sampling. Teknik analisis yang digunakan dalam penelitian ini adalah regresi linier berganda. Berdasarkan hasil penelitian ini, variabel pajak dan kepemilikan asing berpengaruh positif signifikan terhadap keputusan perusahaan menggunakan transfer pricing.
Pengaruh Rasio Likuiditas, Solvabilitas dan Profitabilitas Terhadap Harga Saham Pada Perusahaan Indeks LQ45
Authors: Yunazar Erina Amarvia , Challen Auliffi Ermian , Elmanizar Elmanizar
Published: January 2023

Penelitian ini bertujuan untuk menganalisis pengaruh antara rasio likuiditas, rasio solvabilitas, dan rasio profitabilitas terhadap harga saham. Penelitian ini menggunakan sampel perusahaan yang termasuk dalam indeks LQ45 yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2017-2021. Teknik analisis yang digunakan adalah analisis regresi linier berganda. Pengujian hipotesis yang digunakan adalah uji statistik secara parsial (uji-t) dengan hasil pengujian menunjukkan bahwa hanya variabel rasio solvabilitas berpengaruh negatif terhadap harga saham dan rasio profitabilitas yang berpengaruh positif terhadap harga saham. Sedangkan variabel rasio likuiditas tidak berpengaruh terhadap harga saham.
ANALISIS DANA PIHAK KETIGA DAN SHOCK VARIABLES SELAMA PERIODE PANDEMI PADA BANK UMUM SYARIAH DI INDONESIA
Authors: Yaman Afdhal
Published: January 2023

AbstractDuring the Covid-19 pandemic period, Islamic commercial banks faced growth constraints in receiving and accumulating third-party funds. So it is necessary to observe the factors that influence the growth of DPK. The purpose of this study is to examine external factors in the form of macroeconomic indicators that can affect the growth of third-party funds for Islamic commercial banks in Indonesia. This study used a quantitative research method, the data used were secondary data with a time series type for the period January 2020 - August 2022 and were analyzed using the Vector Auto Regression (VAR) method. The results of this study indicate that the BI Rate has no significant effect on third-party funds. Meanwhile, inflation has a negative and significant effect on the third-party funds of Islamic commercial banks in Indonesia.Keywords: Third-Party Funds, Shock Variables, Sharia Commercial Banks AbstrakSelama periode pandemi covid-19, bank umum syariah menghadapi hambatan pertumbuhan dalam menerima dan menghimpun Dana Pihak Ketiga (DPK). Sehingga perlu diamati faktor-faktor yang berpengaruh pertumbuhan DPK. Tujuan dari penelitian ini adalah untuk menguji faktor-faktor eksternal berupa indikator makro-ekonomi yang dapat memengaruhi pertumbuhan DPK bank umum syariah di Indonesia. Penelitian ini menggunakan metode penelitian kuantitatif, data yang digunakan adalah data sekunder dengan tipe runtut waktu (time series) periode Januari 2020 - Agustus 2022, dan dianalisis dengan menggunakan metode Vector Auto Regression (VAR). Hasil penelitian ini menunjukkan bahwa BI Rate tidak memiliki pengaruh yang signifikan terhadap DPK. Sedangkan inflasi memengaruhi secara negatif dan signifikan terhadap DPK bank umum syariah di indonesia.Kata Kunci: Dana Pihak Ketiga, Variabel Guncangan, Bank Umum Syariah
Noninvasive serum biomarkers for liver steatosis in nonalcoholic fatty liver disease: Current and future developments
Authors: Ahn Sang Bong
Published: January 2023

Nonalcoholic fatty liver disease (NAFLD) affects approximately 30% of the population worldwide and includes nonalcoholic fatty liver, nonalcoholic steatohepatitis (NASH), and cirrhosis. Since NAFLD-associated diseases begin with steatosis, the early diagnosis of steatosis helps to prevent the progression of NASH and fibrosis. In addition, more convenient and easily diagnosable serum biomarkers are becoming crucial in disease diagnosis. In this report, we summarize the known serum biomarkers for liver steatosis and provide guidance for their application in clinical practice.
Anti-pathogenic properties of non-digestible oligosaccharides. The fight against bacterial pathogens and toxins.
Authors:   , Asadpoor Mostafa
Published: January 2023

Despite effective prevention and control efforts over the past few decades, infectious diseases continue to pose a serious threat to global public health, causing millions of deaths annually. Numerous antibiotics can treat bacterial infections. However, practically almost all antimicrobial drugs now have some level of resistance, creating a severe global health issue and the urgent and rapid development of antibiotic alternatives.
It has been demonstrated that NDOs are significant inhibitors of the development of pathogenic infections. Several anti-pathogenic effects can be achieved by NDOs, depending on their type and structural characteristics. This thesis suggests that Non-digestible oligosaccharides (NDOs) may serve as an alternative to antibiotics in treating bacterial infections. In our studies we investigated the effects of NDOs (AOS, COS, FOS and GOS) on the defense against several common bacterial pathogens (E. coli, S. agalactia, S. aureus, and C. difficile) in different steps of the pathogenesis: bacterial growth, bacterial adhesion, biofilm formation, inflammation and bacterial toxin activity. Each of these NDOs had some unique potentials against particular pathogens. Likewise, COS can be described as a potent biofilm inhibitor against S. aureus, a strong inhibitor of shiga toxin binding to its receptor (Gb3), a great inhibitor of cytotoxicity and cytopathogenicity of TcdA, an effective anti-inflammatory agent against inflammation caused by E. coli with intestinal barrier-protective properties and an enhancer of human intestinal epithelial cell integrity. Besides, AOS can be defined as a powerful inhibitor of the growth of both GBS and E. coli, an effective inhibitor of the adhesion of E. coli to intestinal epithelial cells, a potent anti-inflammatory agent against inflammation induced by E. coli, and an effective mediator on TcdA's ability to disrupt the intestinal barrier. The knowledge about the antimicrobial strategies of NDOs was used to further investigate in combination therapy by combining NDO with antibiotics to increase bacterial sensitivity to specific antibiotics. Likewise, a combination of COS and clindamycin was successful in preventing the growth of a S. aureus biofilm, as was a combination of AOS and ampicillin in the case of E. coli growth. AOS and trimethoprim were also successful in treating GBS when combined.
NDOs are a desirable weapon in the fight against pathogens and antibiotic resistance due to their variety of antibacterial capabilities and minimal reported adverse effects. Moreover, a healthy microbiota plays a vital role in infection prevention by inhibiting pathogenic bacteria and/or coordinating proper immune responses, therefore the effect of NDOs on promoting beneficial bacteria in the gut should not be ignored.
Next Generation Sequencing: A Tool for This Generation of Nephrologists
Authors: Landolt Lea , Strauss Philipp , Marti Hans-Peter , Eikrem Øystein
Published: January 2023

The emergence of next generation sequencing (NGS) techniques has made the sequencing of whole genomes, transcriptomes, and epigenomes faster and more readily available than previous methods such as Sanger sequencing, which was developed in the 1970s. It is now 10 years since NGS began to revolutionise biological and medical research. Sequencing of RNA provides insights into up or downregulated gene expression patterns and therefore into molecular disease mechanisms. This can lead to the detection of new biomarkers that can be used as diagnostic tools in risk stratification, or even as new therapeutic targets. In nephrology, NGS plays a role in both basic and experimental research, but also in the clinical setting, whereby the diagnosis of innate genetic diseases such as ciliopathies or genetically moderated acquired diseases such as glomerulopathies has improved. NGS enables precise diagnosis and classification of common diseases of the kidneys and urinary tract, aids in both prognostic and predictive decision-making, and in the avoidance of unnecessary therapies. It also plays a role in the risk stratification of disease recurrence after transplantation. NGS is a robust method; however, the performance of NGS is dependent on the method of tissue storage, the extraction of DNA or RNA, and on the sequencing platform itself, as well as on the bioinformatic analyses performed, integration of clinical data, and comprehensive interpretation of the results. The aim of this article is to review and emphasise the importance of NGS as a tool for this generation of nephrologists.
Initial Evidence in Thromboangiitis Obliterans (Buerger’s Disease) Treatment with Bosentan
Authors: de Haro Joaquín , Bleda Silvia , Acin Francisco
Published: January 2023

Thromboangiitis obliterans (TAO) is a vascular disease that affects small and medium-sized arteries and veins of both upper and lower extremities. Distal ischaemic lesions and digital necrotic ulcers, as well as major amputation rates, among these patients are not negligible. So far, no treatment option has been demonstrated to be completely effective for this disease. Endothelin-1 (ET-1) has been increasingly associated to vascular damage. Furthermore, elevated levels of ET-1 have been proved in TAO patients. Thus, ET-1 receptor antagonists may be considered as a treatment option in this disease.

Consistently, initial results from open-label studies or case reports show promising efficacy of bosentan for treatment and prevention of digital ulcers in TAO with a favourable safety profile. In any case, bosentan should be further investigated in TAO patient management. To confirm initial promising findings, larger controlled randomised trials with a control group are needed. In the meantime, bosentan should be considered as a hopeful investigational agent for treating these patients.
Membrane Flexibility and Cellular Energy Management in Type 2 Diabetes, Gestational Diabetes, and Obesity
Authors: Weijers Rob N.M.
Published: January 2023

In the search to understand the onset of life’s biochemistry, scientists attached a great deal of importance to unravelling the replication mechanism of a cell, and the cell membrane was accepted as an indispensable entity. In this review, we give an account of the recent progress of the understanding that the cell membrane has also continuously evolved over the long-term, leading to the important insight that the membrane unsaturation index (USI) – a measure of unsaturation – plays a pivotal role in the basal metabolic rate of a cell and in the aetiology of Type 2 diabetes mellitus (T2DM). It is now clear that increasing the USI with long- term interventions – in the form of aerobic exercise and caloric restriction – can contribute to the prevention or postponement of the onset of T2DM, gestational diabetes, and prediabetic obesity.
Coronary Bifurcation Disease and Bifurcation Stenting: A Practical Approach
Authors: Colantonio Riccardo , Romagnoli Enrico , Sangiorgi Giuseppe
Published: January 2023

Approximately 20% of percutaneous coronary interventions (PCIs) are performed to treat coronary bifurcations. PCIs in bifurcation lesions have been associated with lower procedural success rates and worse clinical outcomes than non-bifurcation lesions. In addition, PCIs in bifurcation are renowned for being technically demanding. Indeed, there are several challenges in percutaneous treatment of bifurcation lesions to take into account, including: 1) localisation, size, and angle of bifurcation branches in coronary tree (e.g. left main versus others); 2) disease extension at bifurcation (true versus pseudo-bifurcation lesions); 3) stenting technique; and finally 4) choice of the most appropriate device. Several studies have been published in each of these settings, but therapeutic strategies are still linked mostly to clinical setting and operator experience. In this review, we have summarised the most important aspects and clinical studies on bifurcation lesion treatment with the aim to give the readers a practical approach to bifurcation PCI.
HUBUNGAN PENGETAHUAN DAN SIKAP DENGAN PERILAKU MEROKOK SISWA SMAN 3 KOTA PAGAR ALAM
Authors: Ningsih Dwi putri Sulistiya , Dirhan Dirhan , Refoliza Gemala
Published: January 2023

Smoking behavior is considered very detrimental and has shifted to pleasant behavior, especially among schools, one of which is at the high school level. This makes students smoke in schools more. This study aims to study the relationship between knowledge and attitudes toward smoking behavior among SMAN 3 Pagar Alam students. This type of research uses a cross-sectional design to determine the sample size. The determination of the sample size using Proportional Random Sampling is as many as 64, as the sample of this study, data collection techniques using primary and secondary data, and data analysis methods using Univariate and Bivariate analysis with the Chi-Square test to determine the closeness of the relationship seen from the value of the Contingency Coefficient (C). The results showed that out of 64 students, 46.9% had less knowledge, 15.6% had sufficient knowledge, and 37.5% had good knowledge. While the relationship between attitudes and smoking behavior of students is 36 students who support and 28 students who do not support smoking behavior. There is a significant relationship between knowledge and student behavior with a value of p <0.05 (0.000) with a Contingency Coefficient (C) value category of 0.601 (strong relationship category). There is a significant relationship between the attitudes and smoking behavior of students with a p value of 0.05 (0.000) and a Contingency Coefficient (C) value of 0.672 (strong relationship category).Keywords: Knowledge, Attitude, Student Smoking Behavior.
LITERATURE REVIEW: EDUKASI PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) SEBAGAI UPAYA PENCEGAHAN PENULARAN COVID-19
Authors: Raodah Raodah , Handayani Lina
Published: January 2023

Latar belakang dan Tujuan: Perilaku hidup bersih dan sehat (PHBS) sebagai uapaya pencegahan COVID-19 dapat dilakukan dengan mencuci tangan dengan benar, menerapkan etika batuk, menjaga jarak, dan menjaga kebersihan diri sendiri. Hal ini sangat penting sebagai upaya pencegahan penularan COVID-19.  Metode: Penelitian ini menggunakan metode literature review. Artikel yang dikumpulkan dari database Google Scholar dan Kategori Sinta 2 dan 4 dengan rentang waktu 2020-2021. Kata kunci yang digunakan yaitu edukasi, COVID-19 dan PHBS.  Hasil: Ditemukan 377 artikel kemudian dilakukan penyaringan kembali berdasarkan kriteria inklusi dan ekslusi serta memperhatikan pembahasannya dengan detail hingga didapat 20 artikel untuk dianalisis. Subyek dengan kategori anak usia sekolah dasar (SD) dominan untuk dan efektif diberikan edukasi mengenai PHBS dengan metode penyuluhan.  Kesimpulan: Subjek penelitian edukasi PHBS sebagai salah satu pencegahan COVID-19 siswa sekolah dasar, dengan dengan menggunakan metode penyuluhan untuk meningkatkan pengetahuan dan pemahaman mengenai PHBS Kata Kunci: COVID-19, siswa sekolah dasar, penyuluhan
PERLUASAN THEORY OF PLANNED BEHAVIOR DALAM MENJELASKAN FAKTOR-FAKTOR YANG MEMENGARUHI INTENSI MENERAPKAN PERILAKU HIDUP SEHAT PADA MASA COVID-19
Authors: Alyssa Luthfia Nur , Fuady Ikhsan
Published: January 2023

The COVID-19 that has hit the world makes healthy living behavior very important to do as a preventive measure. In implementing a healthy lifestyle, there are several factors that influence the intention to do so. The main purpose of this study was to determine the effect of using Instagram to seek health information, subjective norms, behavioral control, and attitudes towards students' intentions in implementing healthy living behaviors. The theory used is the expansion of the Theory of Planned Behavior. The population of this study is active college students aged 18-24 years, domiciled on the island of Java, and have or are currently using Instagram. The total sample used is 121 people. Data was collected through the distribution of online questionnaires. The results of the data were tested using descriptive statistical analysis and multiple linear regression. The results obtained show that the use of Instagram for health information and subjective norms partially has no effect on the intention of healthy living behavior. Another result is that partially attitude and behavioral control affect students' intentions to implement healthy lifestyle behaviors.
PROMOSI KESELAMATAN DAN KESEHATAN KERJA DI INDUSTRI INFORMAL KRIPIK SINGKONG TAHUN 2021
Authors: Putri Adini Anggun Risanti , Ayu Friska
Published: January 2023

In 2003, 3.2% of the total United States workforce lost productive time due to low back pain (Colorodo Department of Public Health and Environmental Occupational Health, 2012).Occupational Health and Safety (K3), namely to create a safe and secure work environment for workers or employees in the industry concerned, this industry has potential hazards to health, one of which is Low Back Pain (LBP) is a very serious world health problem. In general, it can cause activity restrictions as well as absenteeism from work, commonly felt low back pain. UD. Barokah is a cassava chips industry in Mojokerto. In this research method using pretest and posttest, video counseling about Low Back Pain. The results of the research that were obtained before seeing the counseling video had understood about Low Back Pain by answering the pretest questions, there were 3 respondents (20%). The second did a posttest after seeing the counseling video, they understood about Low Back Pain by answering the posttest questions of 9 respondents (60%). Keywords: Low Back Pain, Occupational Health and Safety, Cassava Chips.
Analisis Keberadaan Mikrobiologi Air Minum Depot Air Minum
Authors: Iqbal Muhamad , Kamaludin Ade , Gumiyarna Hana
Published: January 2023

Tingginya kebutuhan manusia akan air minum harus dibarengi dengan kualitas dan kuantitas yang baik.  Depot air minum merupakan salah satu jawaban atas permasalahan penyediaan air minum di perkotaan. Pengawasan dan pembinaan yang kurang dari pemerintah setempat serta tingkat kepatuhan pengusaha yang kurang akan berdampak pada air hasil olahan depot air minum. Mengidentifikasi kualitas dan hygiene sanitasi depot air minum. Penelitian ini merupakan penelitian deskriptif dengan 60 sampel. Teknik pengambilan sampel menggunakan purposive sampling. Pemeriksaan mikrobiologi air menggunakan metode plate agar yang diinkubasi pada incubator. Observasi dilakukan menggunakan Permenkes 43 tahun 2014 tentang hygiene sanitasi didapatkan bahwa bahwa tempat 66,67%, peralatan 91,67%, dan penjamah 38,33% dikategorikan laik.  Uji laboratorium terhadap air baku didapat air PDAM 75%, mata air 56,5% air sumur 0% kategori memenuhi syarat. Pada air minum terdapat 65% parameter coliform dan 80% dan 35% parameter E.coli dikategorikan memenuhi syarat. Metode desinfeksi menggunakan RO mereduksi 23,16% coliform dan 12% E.coli lebih baik dari Non RO. Bahan baku yang paling baik adalah sumber air dari PDAM. Hygiene sanitasi depot relatif baik untuk peralatan, sedangkan untuk tempat dan penjamah kualitasnya dinilai masih kurang sehingga harus dilakukan pengawasan terhadap hygiene sanitasi. Metode desinfeksi reverse osmosis merupakan metode yang paling baik mereduksi bakteri.
PENERAPAN MODEL UTAUT 2 UNTUK MENGETAHUI MINAT PENGGUNAAN APLIKASI SI-GEMBUL PADA KADER POSYANDU DI PUSKESMAS HALMAHERA SEMARANG
Authors: Santi Melania Nur , Nurmandhani Ririn , Setyawati Vilda Ana Veria , Rimawati Eti , Wardoyo Agung , Iqbal Muhammad
Published: January 2023

SI-GEMBUL (Integrated Information System for Nutritional Status of Superior Toddlers) is an application made to collect data and handle stunting cases at Puskesmas Halmahera. Along with the increase in cases of stunting, efforts need to be made to accelerate stunting prevention in toddlers. The purpose of this study was to determine the relationship between performance expectations, business expectations, hedonistic motivation, and price value with the intention of using the SI-GEMBUL application at Puskesmas Halmahera. The type of research used in this study was quantitative research with a cross-sectional approach. The method used was the UTAUT2 method. The samples in this study were all health cadres in RW 12 and RW 14 of Rejosari Village, who were selected by purposive sampling technique. The results showed that there was a relationship between the factors of performance expectations, business expectations, hedonistic motivation, and price value to the intention to use the SI-GEMBUL application, with a significance value (sig) of 0.014 for the performance expectation variable, a significance value (sig) of 0.003 for the business expectation variable, a significance value (sig) of 0.001 for the hedonistic motivation variable, and a significance value (sig) of 0.014 for the price value variable. The advice that can be given is that health cadres can help each other using the SI-GEMBUL application and puskesmas can monitor the health cadres regarding the use of the SI-GEMBUL application so puskesmas can take advantage of the SI-GEMBUL application in the future.
GAMBARAN PERBEDAAN KONSENTRASI EKSTRAK ETANOL DAUN KUNYIT (Curcuma longa L.) TERHADAP TOTAL FENOLIK SECARA SPEKTROFOTOMETRI VISIBEL
Authors: Anggoro Aloysius Barry , Purwaningsih Yuliana , WS FX Sulistiyanto , Indriyanti Erwin
Published: January 2023

Turmeric leaves (Curcuma longa L.) contain secondary metabolites, one of which is a phenolic compound. The choice of solvent is important in the extraction process, ethanol is chosen because it can attract compounds that are soluble in non-polar to polar solvents. The ethanol concentrations in this study were 60, 70, 80, and 96% with the extraction method used was maceration. The screening test obtained positive results for phenolic content. This is indicated by the appearance of a fluorescent blue-black stain on the plate after being sprayed with FeCl3 reagent. TLC test obtained comparison Rf value (gallic acid) is 0.53. Rf values for ethanol concentrations of 60, 70, 80, 90 and 96% were 0.53; 0.55; 0.57; 0.60; 0.60. The method used to determine the total phenolic content is folin-ciaocalteu. Analysis with visible spectrophotometry obtained the average total phenolic content of ethanol extract concentrations of 60, 70, 80, 90 and 96%, respectively 1.078; 1.796; 1.964; 1.842; and 1.787 GAE mg/g extract. The results of statistical tests obtained data that are normally distributed but not homogeneous, there are significant differences at concentrations of 60, 80, and 96%. The conclusion was that the highest phenolic content was in the ethanol extract of turmeric leaf with a concentration of 80%, there was an effect of ethanol concentration on the total phenolic content of the turmeric leaf ethanol extract, and there were differences in the total phenolic content at each concentration of ethanol used.Keywords :Turmeric Leaves (Curcuma longa L.), Total Phenolic Level, Ethanol Concentration, Visible Spectrophotometry
Energy landscape controllers for quantum state transfer in spin-1/2 networks with ring topology
Authors: Langbein Frank , O'Neil Sean , Shermer Sophie
Published: January 2023

This data set contains energy landscape controllers for information propagation in networks of spin-1/2 particles (qubits) with a ring topology and uniform nearest neighbor couplings of XXZ type. The controllers are optimized to maximize the fidelity of excitation transfer between nodes of ring in the single excitation subspace. The network can be regarded as simple prototype of a router for spin-based information. The dataset contains controllers for rings ranging in size from 3 to 20 spins with excitation transfer from node 1 to nodes 2, 3, ... ceil(N/2) considered. Controllers optimized for both instantaneous readout and time-windowed (finite bandwidth) readout are included.
A novel hybrid design and modelling of a customised graded Ti-6Al-4V porous hip implant to reduce stress-shielding: An experimental and numerical analysis
Authors: Naghavi Seyed Ataollah , Tamaddon Maryam , Garcia-Souto Pilar , Moazen Mehran , Taylor Stephen , Hua Jia , Liu Chaozong
Published: January 2023

Stress shielding secondary to bone resorption is one of the main causes of aseptic loosening, which limits the lifespan of hip prostheses and exacerbates revision surgery rates. In order to minimise post-hip replacement stress variations, this investigation proposes a low-stiffness, porous Ti6Al4V hip prosthesis, developed through selective laser melting (SLM). The stress shielding effect and potential bone resorption properties of the porous hip implant were investigated through both in vitro quasi-physiological experimental assays, together with finite element analysis. A solid hip implant was incorporated in this investigation for contrast, as a control group. The stiffness and fatigue properties of both the solid and the porous hip implants were measured through compression tests. The safety factor of the porous hip stem under both static and dynamic loading patterns was obtained through simulation. The porous hip implant was inserted into Sawbone/PMMA cement and was loaded to 2,300 N (compression). The proposed porous hip implant demonstrated a more natural stress distribution, with reduced stress shielding (by 70%) and loss in bone mass (by 60%), when compared to a fully solid hip implant. Solid and porous hip stems had a stiffness of 2.76 kN/mm and 2.15 kN/mm respectively. Considering all daily activities, the porous hip stem had a factor of safety greater than 2. At the 2,300 N load, maximum von Mises stresses on the hip stem were observed as 112 MPa on the medial neck and 290 MPa on the distal restriction point, whereby such values remained below the endurance limit of 3D printed Ti6Al4V (375 MPa). Overall, through the strut thickness optimisation process for a Ti6Al4V porous hip stem, stress shielding and bone resorption can be reduced, therefore proposing a potential replacement for the generic solid implant.
Debridement of contaminated implants using air-polishing coupled with pH-responsive maximin H5-embedded metal-organic frameworks
Authors: Zhu Yu , Zhi Qiang , Zhang Chunan , Gu Yingxin , Liu Shuli , Qiao Shichong , Lai Hongchang
Published: January 2023

The primary goal of peri-implantitis treatments remains the decontamination of implant surfaces exposed to polymicrobial biofilms and renders biocompatibility. In this study, we reported a synergistic strategy for the debridement and re-osteogenesis of contaminated titanium by using erythritol air abrasion (AA) coupled with an as-synthesized pH-responsive antimicrobial agent. Here, the anionic antibacterial peptide Maximin H5 C-terminally deaminated isoform (MH5C) was introduced into the Zeolitic Imidazolate Frameworks (ZIF-8) via a one-pot synthesis process. The formed MH5C@ZIF-8 nanoparticles (NPs) not only possessed suitable stability, but also guarantee the slow-release effect of MH5C. Antibacterial experiments revealed that MH5C@ZIF-8 NPs exhibited excellent antimicrobial abilities toward pathogenic bacteria of peri-implantitis, confirming ZIF-8 NPs as efficient nanoplatforms for delivering antibacterial peptide. To evaluate the comprehensive debridement efficiency, single-species as well as mixed-species biofilms were successively established on commercially used titanium surfaces and decontaminated with different methods: removed only by erythritol air abrasion, treated merely with MH5C@ZIF-8 NPs, or received both managements. The results demonstrated that only erythritol air abrasion accompanied with MH5C@ZIF-8 NPs at high concentrations eliminated almost all retained bacteria and impeded biofilm rehabilitation, while neither erythritol air abrasion nor MH5C@ZIF-8 NPs alone could achieve this. Subsequently, we evaluated the re-osteogenesis on previously contaminated surfaces which were treated with different debridement methods afterwards. We found that cell growth and osteogenic differentiation of bone marrow–derived mesenchymal stem cells (BMSCs) in the group received both treatments (AA + MH5C@ZIF-8) were higher than those in other groups. Our work emphasized the great potential of the synergistic therapy as a credible alternative for removing microorganisms and rendering re-osseointegration on contaminated implant surfaces, boding well for the comprehensive applications in peri-implantitis treatments.
Low-field NMR investigations on dynamics of crude oil confined into nanoporous silica rods and white powder
Authors: Ok Salim
Published: January 2023

In the present study, to mimic the natural confinement of crude oils, model experiments are conducted with crude oils having different physical properties and maltenes of parent crude oils without asphaltenes confined into engineered nanoporous silica rods with pore diameters of 2.5 and 10.0 nm and white powdered nanoporous silica with pore diameters of 2.5 and 4.0 nm. This will help with suggesting potential treatments for enhancing crude oil recovery. Low-field nuclear magnetic resonance (LF-NMR) relaxometry has been applied to achieve this goal. The nanoporous proxies resemble real-life nanoporous rocks of reservoirs. The dynamics of confined crude oils with different oAPI gravity deviate from bulk dynamics, and deviation changes depending on the oAPI gravity. This suggests that treatments must be decided appropriately before crude oil production. Similar treatments could be applied for light and medium-heavy crude oils. Mathematical analysis of NMR relaxation curves of confined crude oils with different fractions of SARA (saturates, aromatics, resins, asphaltenes) indicates that the conventional SARA approach needs a better definition for the confined state of matter. The NMR relaxation behavior of confined maltenes shows that resin molecules might act like saturates in natural confinement with various scale pores from nano to micro and even macro, or aromatics might show resin-like behaviors. Confinement of brine and a light crude oil into white powdered nanoporous silica proxies demonstrates that brine could be utilized along with some additives such as nanoparticles for oil recovery. Therefore, these issues must be evaluated in deciding the proper treatments for crude oil production.
In vitro contraceptive activities, molecular docking, molecular dynamics, MM-PBSA, non-covalent interaction and DFT studies of bioactive compounds from Aegle marmelos. Linn., leaves
Authors: Gunasekaran Prasanth , Velmurugan Yogaswaran , Arputharaj David Stephen , Savaridasson Jose Kavitha , Hemamalini Madhukar , Venkatachalam Rajakannan
Published: January 2023

Introduction: Bioactive molecules from natural sources having contraceptive properties were excellent alternatives for modern hormonal contraceptives. Researchers around the world were working on identifying contraceptive leads targeting the male reproductive system rather than the usual female contraceptives. The lack of proper understanding on male contraceptive protein drug targets leads to insufficient evidence on activities of identified contraceptive compounds. The proteins specific to the male reproductive system and involved in sperm-egg fusion will be an excellent drug target to identify the male non-hormonal, reversible contraceptive leads. Inhibiting sperm hyaluronidase activity by natural non-hormonal compounds will lead to reversible and non-hormonal male contraception. The Aegle marmelos Linn. is one such important medicinal plant with valuable phytocompounds, used traditionally as a potential contraceptive measure. The in vivo experiments on leaf extracts of Aegle marmelos. Linn containing terpenes, sterols, and alkaloids shows prominent contraceptive activities. Moreover, this study explores the potential ability of the leaf extract on inhibiting the sperm hyaluronidase action with additional molecular details on the interaction between sperm hyaluronidases and three phytocompounds such as aegeline, marmin, and marminol.

Material and methods: The in vitro hyaluronidase inhibition assay and Computer Assisted Sperm Analysis (CASA) were used to evaluate the male contraceptive properties of the Aegle marmelos Linn. leaf extract. To identify the interaction profile of aegeline, marmin, and marmenol on sperm cell hyaluronidases the in-silico methods such as molecular docking, Non-Covalent Interaction analysis, Molecular dynamics, and Molecular Mechanics Poisson Boltzmann Surface Area were used.

Results and discussion: The results of in vitro hyaluronidase inhibition assay and Computer Assisted Sperm Analysis shows the inhibition of hyaluronidase enzymatic activity and reduced sperm activities in the presence of leaf extracts. After incubation with leaf extracts for about 30 minutes time intervals show, the motility drops from progressive to non-progressive and ended up with complete immotile in 100 μg/ml concentration of leaf extract. The results of molecular docking, Non-Covalent Interaction analysis, Molecular dynamics, and Molecular mechanics Poisson Boltzmann Surface Area show that the phytocompounds marmin, and aegeline have the potential ability to inhibit sperm hyaluronidase.
Engineering zinc oxide hybrid selenium nanoparticles for synergetic anti-tuberculosis treatment by combining Mycobacterium tuberculosis killings and host cell immunological inhibition
Authors: Lin Wensen , Fan Shuhao , Liao Kangsheng , Huang Yifan , Cong Yanguang , Zhang Junai , Jin Hua , Zhao Yi , Ruan Yongdui , Lu Hongmei , Yang Fen , Wu Changxian , Zhao Daina , Fu Zhendong , Zheng Biying , Xu Jun-Fa , Pi Jiang
Published: January 2023

Introduction

As a deadly disease induced by Mycobacterium tuberculosis (Mtb), tuberculosis remains one of the top killers among infectious diseases. The low intracellular Mtb killing efficiency of current antibiotics introduced the long duration anti-TB therapy in clinic with strong side effects and increased drug-resistant mutants. Therefore, the exploration of novel anti-TB agents with potent anti-TB efficiency becomes one of the most urgent issues for TB therapies.

Methods

Here, we firstly introduced a novel method for the preparation of zinc oxide-selenium nanoparticles (ZnO-Se NPs) by the hybridization of zinc oxide and selenium to combine the anti-TB activities of zinc oxide nanoparticles and selenium nanoparticles. We characterized the ZnO-Se NPs by dynamic laser light scattering and transmission electron microscopy, and then tested the inhibition effects of ZnO-Se NPs on extracellular Mtb by colony-forming units (CFU) counting, bacterial ATP analysis, bacterial membrane potential analysis and scanning electron microscopy imaging. We also analyzed the effects of ZnO-Se NPs on the ROS production, mitochondrial membrane potential, apoptosis, autophagy, polarization and PI3K/Akt/mTOR signaling pathway of Mtb infected THP-1 macrophages. At last, we also tested the effects of ZnO-Se NPs on intracellular Mtb in THP-1 cells by colony-forming units (CFU) counting.

Results

The obtained spherical core-shell ZnO-Se NPs with average diameters of 90 nm showed strong killing effects against extracellular Mtb, including BCG and the virulent H37Rv, by disrupting the ATP production, increasing the intracellular ROS level and destroying the membrane structures. More importantly, ZnO-Se NPs could also inhibit intracellular Mtb growth by promoting M1 polarization to increase the production of antiseptic nitric oxide and also promote apoptosis and autophagy of Mtb infected macrophages by increasing the intracellular ROS, disrupting mitochondria membrane potential and inhibiting PI3K/Akt/mTOR signaling pathway.

Discussion

These ZnO-Se NPs with synergetic anti-TB efficiency by combining the Mtb killing effects and host cell immunological inhibition effects were expected to serve as novel anti-TB agents for the development of more effective anti-TB strategy.