bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental and theoretical studies of a novel europium decorated carbon nanotube material: investigation of cytotoxicity, electrocatalytic properties, and corrosion inhibition behaviour on Mg AZ31 alloy in 3.5% NaCl environment
Authors: Nagarajan Palaniappan , Cole Ivan , Deng Qiushi , Kuznetsov Aleksey , Oz Tuba , Kujawska Malgorzata
Published: October 2024

Leveraging rare-earth elements as one of the eco-friendly candidates to protect alloy coatings, this study performed the europium functionalization of carbon nanotubes (Eu–CNT) for magnesium alloy protection in the 3.5% NaCl medium.
Small but mighty: nanoemulsion particle size dictates bone regeneration potential of FTY720
Authors: Rasoulian Bita , Poormoghadam Delaram , Hoveizi Elham , Rezayat Seyed Mahdi , Tavakol Shima
Published: October 2024

Ultrasound-synthesized nanocarriers demonstrate superior performance in bone regeneration compared to their larger counterparts. This highlights the advantages of this approach: smaller particle size, reduced viscosity, and accelerated drug release.
Carbon-supported Au25 cluster catalysts partially decorated with dendron thiolates: enhanced loading weight and durability for hydrogen evolution reaction
Authors: Sakamoto Kosuke , Masuda Shinya , Takano Shinjiro , Tsukuda Tatsuya
Published: October 2024

The loading amount and durability of the carbon-supported Au25 cluster catalyst were successfully enhanced by introducing bulky, dendron thiolates, due to (1) strong non-covalent interactions between ligands and support, and (2) steric repulsion.
Self-healable, reprocessable and anti-flammable eugenol-derived covalent adaptable thermosets based on dynamic covalent boronic esters and thiol–ene click chemistry
Authors: Niu Haoxin , Li Yu , Zhang Ping , Guo Wenwen , Wang Xin , Hu Yuan
Published: October 2024

Self-healable and reprocessable eugenol-derived covalent adaptable thermosets were fabricated via dynamic covalent boronic esters and thiol–ene click chemistry.
Strategic pathway selection for photocatalytic degradation: roles of holes and radicals
Authors: Li Yixuan , Gao Xu , Li Yuxin
Published: October 2024

As global resources become scarce and environmental issues become increasingly severe, developing photocatalytic technology for efficiently and cleanly degrading pollutants has become a research trend.
Effect of catalyst and oxidant concentrations in a TEMPO oxidation system on the production of cellulose nanofibers
Authors: Park Jisoo , Lee Danbee , Hwang Kyojung , Lee Jimin , Lee Tai-Ju , Kim Youngsu , Kim Jung Hyeun , Lee Jieun , Youe Won-Jae , Chun Sang-Jin , Gwon Jaegyoung
Published: October 2024

Enhanced TEMPO catalyst activity induced by NaClO content.
Modulating the pH dependent photophysical properties of green fluorescent protein
Authors: Broughton David P. , Holod Chloe G. , Camilo-Contreras Angelica , Harris Darcy R. , Brewer Scott H. , Phillips-Piro Christine M.
Published: October 2024

The photophysical properties of superfolder green fluorescent protein (sfGFP) were successfully modulated by the replacement of tyrosine 66 in the internal chromophore with 3-nitro-l-tyrosine.
Antibacterial activity of structurally diverse natural prenylated isobavachalcone derivatives
Authors: Kumar Puneet , Saini Sapna , Gangwar Anjali , Sharma Rashmi , Anal Jasha Momo H.
Published: October 2024

Naturally occurring prenylated Isobavachalcone and derivatives show antibacterial properties against clinically significant pathogens and demonstrated robust antimicrobial activity.
Bifunctional catalysts for the coupling processes of CO2 capture and conversion: a minireview
Authors: Dang Chengxiong , Yu Hao
Published: October 2024

A bifunctional catalyst for integrated CO2 capture and utilization (ICCU).
Development and simulation of annular flow photoreactors: integration of light-diffusing fibers as optical diffusers with laser diodes
Authors: Carrillo De Hert Sergio , Lopez-Rodriguez Rafael , Di Maso Michael J. , McMullen Jonathan P. , Ferguson Steven
Published: October 2024

Laser driven platform for photochemical reactions. Modelling: predictability and optimization.
Quantitative analysis of air-oxidation reactions of thiolate-protected gold nanoclusters
Authors: Suzuki Wataru , Takahata Ryo , Mizuhata Yoshiyuki , Tokitoh Norihiro , Xue Songlin , Teranishi Toshiharu
Published: October 2024

The interaction of dioxygen (O2) with inorganic nanomaterials is one of the most essential steps to understanding the reaction mechanism of O2-related reactions.
New frontiers in alkali metal insertion into carbon electrodes for energy storage
Authors: Gossage Zachary T. , Igarashi Daisuke , Fujii Yuki , Kawaguchi Masayuki , Tatara Ryoichi , Nakamoto Kosuke , Komaba Shinichi
Published: October 2024

With rising interest in new electrodes for next-generation batteries, carbon materials remain as top competitors with their reliable performance, low-cost, low voltage reactions, and diverse tunability.
Cyclic peptides targeting the SARS-CoV-2 programmed ribosomal frameshifting RNA from a multiplexed phage display library
Authors: Iannuzzelli Jacob A. , Bonn Rachel , Hong Andrew S. , Anitha Abhijith Saseendran , Jenkins Jermaine L. , Wedekind Joseph E. , Fasan Rudi
Published: October 2024

Cyclopeptide agents targeted against the −1 programmed ribosomal frameshifting stimulatory sequence RNA pseudoknot of SARS-CoV-2 were discovered by screening a multiplexed phage display library of genetically encoded peptide macrocycles.
Molecular brush-based ultrathin polymer electrolytes with stable interfaces for high-voltage large-areal-capacity lithium metal batteries
Authors: Liao Rongfeng , Li Congping , Zhou Minghong , Liu Ruliang , Liu Shaohong , Wu Dingcai
Published: October 2024

An ultrathin polymer electrolyte with superior ionic conductivity and stable electrolyte/electrode interfaces enables a high-loading Li/NCM811 cell with a capacity retention of up to 71% after 400 cycles at a high cut-off voltage of 4.5 V.
Three-dimensional covalent organic framework-based artificial interphase layer endows lithium metal anodes with high stability
Authors: Zheng Kaiyang , Gou Zhengyang , Zhang Cen , Zhang Yuqiang , Dou Yaying , Liu Shaojie , Zhang Yongheng , Zhang Yantao
Published: October 2024

A 3D COF with a fully covalent dia topology was successfully utilized as artificial SEI layers to modulate the Li+ microscopic dynamics related to Li ion desolvation, charge transfer, migration pathways, and deposition morphology.
Application of surface selective site-directed crystallization in a visual assay of DNA
Authors: Chen Jinrong , Xie Ruwen , Liu Rui , Liu Lishang , Zhang Shusheng
Published: October 2024

Single crystals were used as digital signals for a DNA visual quantification assay using a smartphone.
Unveiling the mechanism of CO2 electroreduction to C1 and C2 products of ordered double transition metal MXenes
Authors: Khanam Romana , Fozia Syed , Dar Manzoor Ahmad
Published: October 2024

First principles simulations to understand the electrocatalytic CO2RR activity of double transition metal MXenes from an electronic structure point of view.
Geometrical impacts of platonic particles on nematic liquid crystal dynamics
Authors: Villada-Gil Stiven , Sadati Monirosadat , Ospina-Correa Juan D. , Olaya-Muñoz Daniel A. , Hernández-Ortiz Juan P. , Martínez-González José A.
Published: October 2024

In this work, we studied the defect dynamics of platonic-like colloidal particles immersed in a nematic liquid crystal under flow conditions, analyzing the behavior of disclinations for each of these polyhedra.
Design and construction of porphyrin box-based metal–organic frameworks with hierarchical superstructures for efficient energy transfer and photooxidation
Authors: Xu Qian , Zhang Peng , Sun Yuanyuan , Chen Jishi , Hou Chuantao , Wang Zonghua
Published: October 2024

A porphyrin box-based MOF with hierarchical superstructures was synthesized, exhibiting enhanced performance in singlet oxygen-mediated photooxidation.
Point-defect chemistry for ionic conduction in solid electrolytes with isovalent cation mixing
Authors: Ogawa Takafumi , Sato Kazuyuki , Mori Kazuhiro , Kobayashi Shunsuke , Moriwake Hiroki , Ikuhara Yuichi , Kuwabara Akihide
Published: October 2024

The atomic-scale mechanism of enhanced ionic conductivity in (Ba,Ca)F2 with isovalent cation mixing is revealed via a first-principles investigation of defect formation and migration.
Recent advances in chemotherapy for cancer therapy over Cu-based nanocatalysts
Authors: Wang Meng-Yu , Li Zhi-Xin
Published: October 2024

The recent progress of various Cu-based nanocatalysts in cancer therapy was reviewed, especially the remarkable achievements in catalytic treatment of cancer in the tumor microenvironment through CDT and CDT-involved multimodal synergies.
The dynamic regulatory network of phosphatidic acid metabolism: a spotlight on substrate cycling between phosphatidic acid and diacylglycerol
Authors: Tei Reika
Published: October 2024

Mammalian cells utilize over 1000 different lipid species to maintain cell and organelle membrane properties, control cell signaling and processes, and store energy. Lipid synthesis and metabolism are mediated by highly interconnected and spatiotemporally regulated networks of lipid-metabolizing enzymes and supported by vesicle trafficking and lipid-transfer at membrane contact sites. However, the regulatory mechanisms that achieve lipid homeostasis are largely unknown. Phosphatidic acid (PA) serves as the central hub for phospholipid biosynthesis, acting as a key intermediate in both the Kennedy pathway and the CDP-DAG pathway. Additionally, PA is a potent signaling molecule involved in various cellular processes. This dual role of PA, both as a critical intermediate in lipid biosynthesis and as a significant signaling molecule, suggests that it is tightly regulated within cells. This minireview will summarize the functional diversity of PA molecules based on their acyl tail structures and subcellular localization, highlighting recent tools and findings that shed light on how the physical, chemical, and spatial properties of PA species contribute to their differential metabolic fates and functions. Dysfunctional effects of altered PA metabolism as well as the strategies cells employ to maintain PA regulation and homeostasis will also be discussed. Furthermore, this review will explore the differential regulation of PA metabolism across distinct subcellular membranes. Our recent proximity labeling studies highlight the possibility that substrate cycling between PA and DAG may be location-dependent and have functional significance in cell signaling and lipid homeostasis.
Artificial Intelligence and the Future of Communication Sciences and Disorders: A Bibliometric and Visualization Analysis
Authors: Zhang Minyue , Tang Enze , Ding Hongwei , Zhang Yang
Published: October 2024

Purpose:

As artificial intelligence (AI) takes an increasingly prominent role in health care, a growing body of research is being dedicated to its application in the investigation of communication sciences and disorders (CSD). This study aims to provide a comprehensive overview, serving as a valuable resource for researchers, developers, and professionals seeking to comprehend the evolving landscape of AI in CSD research.

Method:

We conducted a bibliometric analysis of AI-based research in the discipline of CSD published up to December 2023. Utilizing the Web of Science and Scopus databases, we identified 15,035 publications, with 4,375 meeting our inclusion criteria. Based on the bibliometric data, we examined publication trends and patterns, characteristics of research activities, and research hotspot tendencies.

Results:

From 1985 onwards, there has been a consistent annual increase in publications, averaging 16.51%, notably surging from 2012 to 2023. The primary communication disorders studied include autism, aphasia, dysarthria, Parkinson's disease, and Alzheimer's disease. Noteworthy AI models instantiated in CSD research encompass support vector machine, convolutional neural network, and hidden Markov model, among others.

Conclusions:

Compared to AI applications in other fields, the adoption of AI in CSD has lagged slightly behind. While CSD studies primarily use classical machine learning techniques, there is a growing trend toward the integration of deep learning methods. AI technology offers significant benefits for both research and clinical practice in CSD, but it also presents certain challenges. Moving forward, collaboration among technological, research, and clinical domains is essential to empower researchers and speech-language pathologists to effectively leverage AI technology for the study, diagnosis, assessment, and rehabilitation of CSD.

Supplemental Material:

https://doi.org/10.23641/asha.27162564
A Variational Bayesian Truncated Adaptive Filter for Uncertain Systems with Inequality Constraints
Authors: Ma Tianli , Zhang Rong , Gao Song , Li Hong , Zhang Yang
Published: October 2024

In this paper, a variational Bayesian (VB) truncated adaptive filter for uncertain systems with inequality constraints is proposed. By choosing the skew‐t and inverse Wishart distributions as the prior information of the measurement noise and predicted error covariance matrix, the state vector, the predicted error covariance matrix, and noise parameters are inferred and approximated by using the VB method. To achieve the inequality‐constrained estimation, the constrained state is computed by truncating the probability density function (PDF) of the estimated state after the variational update stage; the mean and covariance of the constrained state are the first and second moments of the truncated PDF. Considering the model uncertainties where the system dynamics are unpredictable, a multiple model VB truncated adaptive filter is proposed in the interacting multiple model framework. The performances of the proposed algorithms are evaluated via the target tracking simulations and the robot positioning experiments. Results show that the proposed algorithms improve estimation accuracy compared with the existing adaptive filters when the states suffer inequality constraints.
High‐speed main protection for multiterminal LCC‐MMC‐UHVDC based on initial wave process comparison
Authors: Li Yan , Li Jun , Li Guiyuan , Cao Runbin , Zeng Xinjie , Tong Ning
Published: October 2024

The multiterminal LCC‐MMC‐UHVDC, which employs an LCC on the rectifier side and multiple FHMMCs on the inverter side, has emerged as a cutting‐edge technology. Nevertheless, distinct disparities in their protection requirements compared to those of conventional DC grids pose notable challenges in attaining the desired attributes. This paper first derives variation patterns in the time domain of initial waves under different fault conditions. By utilizing the theoretically calculated rate‐of‐change waveform for the backward current traveling wave in an external fault scenario as a reference, a main protection relay grounded in initial wave process comparison is proposed. This approach capitalizes on the disparity observed in internal faults with the theoretical waveform. To mitigate maloperations stemming from the employment of a non‐directional start‐up criterion in reverse fault scenarios, subtle noise patterns, mimicking the theoretical waveforms, are infused into the actual waveforms. This approach averts maloperations in reverse faults and obviates the need for added delays associated with directional start‐up criteria, thereby enhancing both speed and security. Case studies demonstrate that the proposed protection offers sufficient selectivity and a resistive tolerance of 600 ohms and boasts a speed of 0.2 ms, satisfying the requirements of 800 kV UHVDC systems.
In situ monitoring of defects in steel structures using a robot‐assisted ultrasonic inspection technique
Authors: Besharatifard Hamidreza , Hasanzadeh Saeed
Published: October 2024

Incidents in extreme environments can bring unprecedented consequences that would endanger the lives of many humans. Real‐time and early detection of cracks and defects in the steel used for the construction of industrial sites can bring many benefits to remote operators and site managers. Although different methods and systems have been proposed in the past, they are not suitable for real‐time fault detection or long‐term operation in harsh environments. Therefore, this paper proposes a low‐power robotic platform with a magnetic actuator mechanism which is capable of wireless inspection of steel structures using the ultrasonic method. The proposed magnetic motion uses the inertia force generated by the piston vibration and the difference in frictional force during movement. The paper evaluates the performance of the steel structure defect detection system from four different perspectives: sensing principle, wireless communication network, driving part, and power supply.
Discovery of a > 13 Mpc long X-ray filament between two galaxy clusters beyond three times their virial radii
Authors: Dietl J. , Pacaud F. , Reiprich T. H. , Veronica A. , Migkas K. , Spinelli C. , Dolag K. , Seidel B.
Published: October 2024

Context. A significant fraction of the missing baryons in the local Universe is expected to reside in large-scale filaments that may be observable in soft X-ray emission. Until now, however, very few candidate emission filaments have been found in individual systems, and none beyond three times the virial radius of the clusters at the nodes of these filaments. The new Spectrum Roentgen Gamma (SRG) eROSITA X-ray telescope has a superior response to extended soft X-rays, which makes it ideal for studying low X-ray surface brightness emission of cosmic filaments.

Aims. We search for extended X-ray emission between the two nearby galaxy clusters Abell 3667 and Abell 3651, which are separated by a projected transverse distance of ~13 Mpc, using data from the SRG/eROSITA All-Sky Survey.

Methods. We performed a detailed X-ray image analysis of the region between the two galaxy clusters and conducted a redshift analysis of the sources between them. We carried out a thorough surface brightness and spectral analysis between the clusters. The analysis was complemented with an X-ray pointed observation from XMM-Newton, infrared 2MASS data, and redshift information from NED.

Results. We discover an emission filament beyond the known radio relic northwest of A3667 and even beyond three times its virial radius. It is smoothly connected to A3651. The X-ray emission in the direction of the filament shows an enhancement of (30 ± 3) % with a significance of 11 σ. The 2MASS map and redshift analysis show an alignment of galaxies along the filament and make a projection effect unlikely. Taking the redshift progression of galaxies within the filament into account, we estimate its three-dimensional length to be in the range of 25 Mpc–32 Mpc. The surface brightness analysis in combination with the temperature T = (0.91−0.11+0.07) keV and metallicity Z = (0.10−0.08+0.05) Z⊙ from the spectral analysis leads to estimates of a total flux, gas mass, and central baryon overdensity of FX = (7.4 ± 1.2)×10−12 erg s−1 cm−2, Mg = (2.7−0.8+1.4) M⊙ and δ0 = 215−50+86.
Eddington ratios of dust-obscured quasars at z ≲ 1: Evidence supporting dust-obscured quasars as young quasars
Authors: Kim Dohyeong , Kim Yongjung , Im Myungshin , Glikman Eilat , Kim Minjin , Urrutia Tanya , Lim Gu
Published: October 2024

Dust-obscured quasars have been suspected of being the intermediate-stage galaxies between merger-driven star-forming galaxies and unobscured quasars. This merger-driven galaxy evolution scenario suggests that dust-obscured quasars exhibit higher Eddington ratios (λEdd) than those of unobscured quasars. However, their high dust obscuration poses challenges to accurately measuring their λEdd using commonly employed bolometric luminosity (Lbol) and black hole mass (MBH) estimators based on the ultraviolet or optical luminosity. Recently, new estimators for Lbol and MBH based on mid-infrared continuum luminosity (LMIR) were established, which are less affected by dust obscuration. These estimators enable the study of a large number of dust-obscured quasars across a wide redshift range. In this study, we measure the λEdd values of 30 dust-obscured quasars at z ≲ 1, the largest sample size to date, using the LMIR-based Lbol and MBH estimators. Our findings reveal that dust-obscured quasars exhibit significantly higher λEdd values compared to unobscured quasars. Moreover, we confirm that the enhanced λEdd values of dust-obscured quasars maintain consistency across the redshift span of 0 to 1. Our results strongly support the picture that dust-obscured quasars are in an earlier stage than unobscured quasars on the merger-driven galaxy evolutionary track.
Dynamical resonances in PHANGS galaxies
Authors: Ruiz-García Marina , Querejeta Miguel , García-Burillo Santiago , Emsellem Eric , Meidt Sharon E. , Sormani Mattia C. , Schinnerer Eva , Williams Thomas G. , Bazzi Zein , Colombo Dario , Gleis Damian R. , Gnedin Oleg Y. , Klessen Ralf S. , Leroy Adam K. , Sánchez-Blázquez Patricia , Stuber Sophia K.
Published: October 2024

Bars are remarkable stellar structures that can transport gas toward centers and drive the secular evolution of galaxies. In this context, it is important to locate dynamical resonances associated with bars. For this study, we used Spitzer near-infrared images as a proxy for the stellar gravitational potential and the ALMA CO(J = 2–1) gas distribution from the PHANGS survey to determine the position of the main dynamical resonances associated with the bars in the PHANGS sample of 74 nearby star-forming galaxies. We used the gravitational torque method to estimate the location of the bar corotation radius (RCR), where stars and gas rotate at the same angular velocity as the bar. Of the 46 barred galaxies in PHANGS, we have successfully determined the corotation (CR) for 38 of them. The mean ratio of the RCR to the bar radius (Rbar) is ℛ = RCR/Rbar = 1.12, with a standard deviation of 0.39. This is consistent with the average value expected from theory and suggests that bars are predominantly fast. We also compared our results with other bar CR measurements from the literature, which employ different methods, and find good agreement (ρ = 0.64). Finally, using rotation curves, we have estimated other relevant resonances such as the inner Lindblad resonance (ILR) and the outer Lindblad resonance (OLR), which are often associated with rings. This work provides a useful catalog of resonances for a large sample of nearby galaxies and emphasizes the clear connection between bar dynamics and morphology.
The MUSE eXtremely Deep Field: Detections of circumgalactic Si II* emission at z  ≳  2
Authors: Kusakabe Haruka , Mauerhofer Valentin , Verhamme Anne , Garel Thibault , Blaizot Jérémy , Wisotzki Lutz , Richard Johan , Boogaard Leindert A. , Leclercq Floriane , Guo Yucheng , Claeyssens Adélaïde , Contini Thierry , Herenz Edmund Christian , Kerutt Josephine , Maseda Michael V. , Michel-Dansac Leo , Nanayakkara Themiya , Ouchi Masami , Pessa Ismael , Schaye Joop
Published: October 2024

Context. The circumgalactic medium (CGM) serves as a baryon reservoir that connects galaxies to the intergalactic medium and fuels star formation. The spatial distribution of the metal-enriched cool CGM has not yet been directly revealed at cosmic noon (z ≃ 2–4), as bright emission lines at these redshifts are not covered by optical integral field units.

Aims. To remedy this situation, we performed the first-ever detections and exploration of extended Si II* emission in the low-ionization state (LIS), referred to as Si II* halos, at redshifts ranging from z = 2 to 4 as a way to trace the metal-enriched cool CGM.

Methods. We used a sample of 39 galaxies with systemic redshifts of z = 2.1–3.9 measured with the [C III] doublet in the MUSE Hubble Ultra Deep Field catalog, whose integration times span from ≃30 to 140 hours. We searched for extended Si II* λ1265, 1309, 1533 emission (fluorescent lines) around individual galaxies. We also stacked a subsample of 14 UV-bright galaxies.

Results. We report five individual detections of Si II* λ1533 halos. We also confirm the presence of Si II* λ1533 halos in stacks for the subsample containing UV-bright sources. The other lines do not show secure detections of extended emission in individual or in stacking analyses. These detections may imply that the presence of metal-enriched CGM is a common characteristic for UV-bright galaxies. To investigate whether the origin of Si II* is continuum pumping, as suggested in previous studies, we checked the consistency of the equivalent width (EW) of Si II* emission and the EW of Si II absorption for the individual halo object with the most reliable detection. We confirm the equivalence, suggesting that photon conservation works for this object and points toward continuum pumping as the source of Si II*. We also investigated Si II* lines in a RAMSES-RT zoom-in simulation including continuum pumping, and find the ubiquitous presence of extended halos.
J-PLUS: The fraction of calcium white dwarfs along the cooling sequence
Authors: López-Sanjuan C. , Tremblay P.-E. , O’Brien M. W. , Spinoso D. , Ederoclite A. , Vázquez Ramió H. , Cenarro A. J. , Marín-Franch A. , Civera T. , Carrasco J. M. , Gänsicke B. T. , Gentile Fusillo N. P. , Hernán-Caballero A. , Hollands M. A. , del Pino A. , Domínguez Sánchez H. , Fernández-Ontiveros J. A. , Jiménez-Esteban F. M. , Rebassa-Mansergas A. , Schmidtobreick L. , Angulo R. E. , Cristóbal-Hornillos D. , Dupke R. A. , Hernández-Monteagudo C. , Moles M. , Sodré L. , Varela J.
Published: October 2024

Aims. We used the Javalambre Photometric Local Universe Survey (J-PLUS) second data release (DR2) photometry in 12 optical bands over 2176 deg2 to estimate the fraction of white dwarfs with the presence of Ca II H+K absorption along the cooling sequence.

Methods. We compared the J-PLUS photometry against metal-free theoretical models to estimate the equivalent width in the J0395 passband of 10 nm centered at 395 nm (EWJ0395), a proxy to detect calcium absorption. A total of 4399 white dwarfs with effective temperatures within 30 000 > Teff > 5500 K and masses of M > 0.45 M⊙ were analyzed. Their EWJ0395 distribution was modeled using two populations, corresponding to polluted and non-polluted systems, to estimate the fraction of calcium white dwarfs (fCa) as a function of Teff. The probability of each individual white dwarf presenting calcium absorption, pCa, was also computed.

Results. The comparison of EWJ0395 with both the measured Ca/He abundance and the identification of metal pollution from spectroscopy shows that EWJ0395 correlates with the presence of Ca II H+K absorption. The fraction of calcium white dwarfs changes along the cooling sequence, increasing from fCa ≈ 0 at Teff = 13 500 K to fCa ≈ 0.15 at Teff = 5500 K. This trend reflects the selection function of calcium white dwarfs in the optical. We compare our results with the fractions derived from the 40 pc spectroscopic sample and from Sloan Digital Sky Survey (SDSS) spectra. The trend found in J-PLUS observations is also present in the 40 pc sample; however, SDSS shows a deficit of metal-polluted objects at Teff < 12 000 K. Finally, we found 39 white dwarfs with pCa > 0.99. Twenty of them have spectra presented in previous studies, whereas we obtained follow-up spectroscopic observations for six additional targets. These 26 objects were all confirmed as metal-polluted systems.

Conclusions. The J-PLUS optical data provide a robust statistical measurement for the presence of Ca II H+K absorption in white dwarfs. We find a 15 ± 3% increase in the fraction of calcium white dwarfs from Teff = 13 500 K to 5500 K, which reflects their selection function in the optical from the total population of metal-polluted systems.
Strengthening one health: Lessons learned of rabies response in Indonesia
Authors: Thursina Tanrypada , Hasanbasri Mubasysyir , Mahendradhata Yodi
Published: October 2024

In recent years, zoonoses have continued to pose a threat to global health, including in Indonesia. Avian influenza infections, rabies cases that remain endemic in many regions, and the COVID-19 pandemic are concrete examples of the dangers of zoonoses. These health issues can be prevented and addressed through the cross-sectoral collaboration for the One Health concept. The One Health concept emphasizes the interconnection between the health sector, animal health, and the environmental sector. One Health concept also promotes essential cross-sectoral collaboration in preventing and controlling zoonoses. As a concept that emphasizes various sectors to address the complex issue of zoonoses, it significantly aids in the rapid and accurate response to case reports and outbreak investigations. However, many health and veterinary health workers are unaware of or do not understand this concept. The lack of knowledge among these workers about the One Health concept can be problematic in managing zoonotic cases in the future, especially given the changing epidemiology of many zoonotic diseases. Despite cross-sectoral collaboration, the absence of the One Health approach results in fragmented and uncoordinated responses to zoonotic case reports, making handling less effective and proactive. Therefore, it is necessary to systematically introduce this concept to health and veterinary health workers through integrated and sustainable educational programs. Education about One Health enhances the skills and capacity of health and veterinary health workers and strengthens the national health system. It also can help to initiate collaboration between the two sectors in a sustainable manner to manage and control zoonotic disease and bridging the gap between them. This collaboration will enable better coordinated and integrated responses to zoonotic threats, ultimately improving the overall efficacy of disease prevention and control programs. Comprehensive introduction and training on One Health must become a priority to ensure that zoonoses do not continue developing and threaten public health in Indonesia.
Waste management analysis at Pujale Wisdom Park UGM cafeteria
Authors: Herawaty Nababan Nelly , Rahma Ashila Naura , Kristina Hana , Rahma Dewi Gayatri , Fadhli Muhammad , Yusuf Muhammad , Prayogo Pribadi Ari
Published: October 2024

This study to describe consumer perspectives on waste management and analyze interventions for waste issues at Pujale Canteen UGM, which is crucial for enhancing public health and sanitation standards. A preliminary study of eight UGM cafeterias revealed that Pujale Canteen UGM achieved a score of 16 out of a total of 36 points on the UGM healthy cafeteria criteria. One hundred and sixty respondents who had visited Pujale Canteen UGM completed a consumer perspective questionnaire. Furthermore, four respondents were interviewed in depth to gain detailed insights. A fishbone analysis was employed to ascertain the priority issues, while the MEER method was utilised to identify potential solutions. The findings were unequivocal: 43.2% of respondents perceived Pujale Canteen UGM as unclean, 44.4% experienced discomfort, and 59.4% reported dissatisfaction. The interviews revealed an urgent need for improvements in sanitation, the provision of a cleaner environment, more effective waste disposal facilities, and the installation of handwashing stations. The fishbone analysis identified "Unclean Pujale Canteen UGM" as the core issue, and interventions were selected using the MEER method, including the provision of waste bins and cleanliness equipment. The primary issue at Pujale Canteen UGM is cleanliness. It is recommended that facilities and cleanliness equipment be provided to improve waste management and overall satisfaction at Pujale Canteen UGM.
Optimizing health promotion: Insights from FGDs with dukuh and cadres in Mulyodadi, Bantul
Authors: Adiratna Widia , Cuyno Mellen Renie , Istiyani Tutik , Ghofuri Nurhayyi Asysyifa , Fuadiyah Haq Zilfani , Lia Ramadona Aditya
Published: October 2024

This study aims to assess the health challenges and the need for health promotion training in Mulyodadi village, Bantul. The focus group discussion (FGD) method was employed, involving the head of sub-villages (dukuh) and cadres, to gather in-depth information. The FGD findings highlighted key health challenges in Mulyodadi, including the prevalence of both communicable and non-communicable diseases, a lack of public awareness about the importance of a healthy lifestyle, and unequal access to health information within the community. It was also found that dukuh and cadres did not conduct widespread health promotion for the general public. Their educational efforts, often delivered through posyandu (integrated healthcare centers), were primarily targeted at parents of infants and toddlers, thus limiting their health promotion knowledge and skills to this context. To optimize their role in community health promotion, dukuh and cadres require health communication training, such as elevator pitch skills training. This training will equip them with the ability to deliver concise, compelling, and effective health promotion messages, thereby addressing the identified health challenges more flexibly in terms of time and place.
Late Ediacaran juvenile magmatism in the Variscan Monts-du-Lyonnais metamorphic complex (Massif Central, France)
Authors: Couzinié Simon , Laurent Oscar , Bouilhol Pierre , Chelle-Michou Cyril , Ganzhorn Anne-Céline , Gardien Véronique , Moyen Jean-François
Published: October 2024

The identification of oceanic sutures is key to understanding the evolution of the Paleozoic Variscan belt and the structure of the West European lithosphere. In the French Massif Central, the suture of the ‘Mid-Variscan’ ocean would be stamped by distinctive lithological formations known as ’Leptynite–Amphibolite Complexes’ (LACs). These formations comprise various Cambrian–Ordovician (meta-)igneous associations, commonly interpreted as representing rifted-margin magmatism, and experienced Devonian (385–360 Ma) high-pressure metamorphism. Our study provides geochronological and geochemical data on mafic–felsic rocks from the Riverie LAC in the Monts-du-Lyonnais metamorphic complex. In the Riverie LAC, metaluminous, amphibole-bearing felsic gneisses represent former tonalites closely associated with mafic rocks (now amphibolites). LA–ICP–MS zircon U–Pb dating reveals a latest Ediacaran (c. 545 Ma) crystallization age for the melt that yielded the tonalites. Whole-rock geochemistry (notably pronounced Nb negative anomalies) and the highly radiogenic zircon Hf isotope compositions, with εHf(545Ma) of c. +11 (within the range expected for the Depleted Mantle reservoir), indicate that the parental melt of the tonalites ultimately originated from a mantle source metasomatized by oceanic slab-derived fluids. The (meta-)mafic rocks share a similar ’arc’ signature and were possibly generated from the same mantle source. The mafic–felsic association of the Riverie LAC is unrelated to the opening and closure of the Mid-Variscan ocean and does not represent its suture. Instead, it can be correlated to a juvenile Ediacaran magmatic event identified throughout the Variscan realm, interpreted as reflecting Cadomian arc/back-arc magmatism.
Evaluation of radiation protection knowledge and practices among Moroccan operating room nurses
Authors: Harbaj I. , Kharchaf A. , Chakir E. , Harbaj S.
Published: October 2024

This descriptive cross-sectional study evaluated radiation protection knowledge and practices among 206 Moroccan operating room nurses through a tailored 37-item self-administered questionnaire. The study population exhibited a predominance of male participants (81.1%) and a significant proportion of young professionals (42.2% aged 20-29). Notably, 91.7% of participants reported no prior formal radiation protection training. Data analysis revealed a mean global knowledge score of 4.98 ± 1.02 out of 10, with only 1.9% of participants achieving a high level of knowledge. Specifically, the mean scores for ionizing radiation (IR) and radiation protection (RP) knowledge reached 5.17 ± 1.05 and 4.79 ± 1.18, respectively, with 1.5% of participants demonstrating high-level understanding in both domains. Statistical analysis revealed significant positive correlations between ionizing radiation (IR) and radiation protection (RP) knowledge scores (r = 0.668, p = 0.000), as well as between global knowledge and practice scores (r = 0.694, p = 0.000). This investigation highlights a significant gap between theoretical understanding and practical application, emphasizing the need for preliminary training programs before operating room assignments and ongoing education initiatives. Such training should prioritize hands-on experience while addressing resource limitations and the influence of existing operational procedures to improve radiological safety in Moroccan operating rooms.
Evaluation of Echinacea purpurea Extracts as Immunostimulants: Impact on Macrophage Activation
Authors: Vieira Sara F. , Gonçalves Samuel M. , Gonçalves Virgínia M. F. , Tiritan Maria E. , Cunha Cristina , Carvalho Agostinho , Reis Rui L. , Ferreira Helena , Neves Nuno M.
Published: October 2024

Echinacea purpurea has been traditionally used to strengthen the immune system. Therefore, herein, we investigated the potential of E. purpurea aqueous extracts (AEs) obtained from flowers (F), leaves (L), or roots (R) as an immune booster in human primary monocyte‐derived macrophages (hMDMs). Additionally, to identify the main class of compounds (phenolic/carboxylic acids vs. alkylamides) responsible for the bioactivity, the three AEs were fractioned by semi-preparative high-performance liquid chromatography (HPLC). The AEs and the isolated phenolic/carboxylic acidic fractions were not cytotoxic for hMDMs for all tested concentrations, as confirmed by the metabolic activity and DNA content assays. Moreover, AE drastically induced the production of the interleukin (IL)-6 and tumor necrosis factor (TNF)-α, with a minimal effect on IL-1β and prostaglandin E2 (PGE2), supporting their potential for macrophage activation. Interestingly, in the presence
of the phenolic/carboxylic acidic fractions, this efficacy considerably decreased, suggesting a complementary effect between compounds. AE also triggered the phosphorylation of the extracellular signal-regulated kinase (ERK) 1/2 and p38 signaling pathways and upregulated the cyclooxygenase (COX)-2 expression in hMDMs. Overall, AE-F was demonstrated to be the most powerful immunostimulant extract that can be related to their higher number in identified bioactive compounds compared to AE-L and AE-R. These results highlight the efficiency of E. purpurea AE to enhance the function of a key cell type of the immune system and their potential as immunostimulant formulations for patients with a compromised immune system due to certain diseases (e.g., acquired immunodeficiencies) and treatments (e.g., chemotherapy).
Progressive Myoclonus Epilepsy and Beyond: A Systematic Review of SEMA6B-related Disorders
Authors: Altıntaş Mert , Yıldırım Miraç , Bektaş Ömer , Teber Serap
Published: October 2024

Progressive myoclonus epilepsy (PME) is a rare, clinically and genetically heterogeneous epilepsy syndrome, and pathogenic variants in the semaphorin 6B (SEMA6B) gene have recently been reported to be among the causes of PME. Cases with pathogenic variants in the SEMA6B gene are extremely rare, only a limited number of cases have been reported in the literature. In this systematic review, we aimed to present a summary of a PME case in which a heterozygous nonsense variant of c.2086C > T p.(Gln696*) in the SEMA6B gene was detected in the etiology and other cases with SEMA6B pathogenic variant in the literature. Except for our case, 35 cases from 12 studies were included. The main clinical findings in these patients were cognitive problems, seizures, gait and speech disturbances, and cognitive and/or motor regression, and they had a wide spectrum of severity. Response to antiseizure medications was also highly variable, almost half of the patients had pharmacoresistant seizures. Patients were divided into four different phenotypic groups according to their clinical presentations: PME (18/36), developmental and epileptic encephalopathy (13/36), neurodevelopmental disorder (4/36), and epilepsy (1/36), respectively. In conclusion, although SEMA6B has been associated with PME, it may actually cause a much broader phenotypic spectrum. Due to their extreme rarity, our knowledge of SEMA6B-related disorders is limited. As with all other rare diseases, each new SEMA6B-related disorder case could contribute to a better understanding of the disease. A better understanding of the disease may allow the development of specific treatment options in the future.
Vanderbilt Clinical Informatics Center Education Strategy: To Infinity and Beyond!
Authors: Russo Elise , McCoy Allison , Mize Dara , Osterman Travis , Nelson Scott , Wanderer Jonathan P. , Wright Adam
Published: October 2024

Background The Vanderbilt Clinical Informatics Center (VCLIC) is based in the Department of Biomedical Informatics (DBMI) and operates across Vanderbilt University Medical Center (VUMC) and Vanderbilt University (VU) with a goal of enabling and supporting clinical informatics research and practice. VCLIC supports several types of applied clinical informatics teaching, including teaching of students in courses, professional education for staff and faculty throughout VUMC, and workshops and conferences that are open to the public.

Objectives In this paper, we provide a detailed accounting of our center and institution's methods of educating and training faculty, staff, students, and trainees from across the academic institution and health system on clinical informatics topics, including formal training programs and informal applied learning sessions.

Methods Through a host of informal learning events, such as workshops, seminars, conference-style events, bite-size instructive videos, and hackathons, as well as several formal education programs, such as the Clinical Informatics Graduate Course, Master's in Applied Clinical Informatics, Medical Student Integrated Science Course, Graduate Medical Education Elective, and Fellowship in Clinical Informatics, VCLIC, and VUMC provide opportunities for faculty, students, trainees, and even staff to engage with Clinical Informatics topics and learn related skills.

Results The described programs have trained hundreds of participants from across the academic and clinical enterprises. Of the VCLIC-held events, the majority of attendees indicated through surveys that they were satisfied, with the average satisfaction score being 4.63/5, and all events averaging a satisfaction score of greater than 4. Across the 20 events VCLIC has held, our largest audiences are DBMI, HealthIT operational staff, and students from the medical and nursing schools.

Conclusion VCLIC has created and delivered a successful suite of formal and informal educational events and programs to disseminate clinical informatics knowledge and skills to learners across the academic institution and health care system.
Electronic Health Record User Dashboard for Optimization of Surgical Resident Procedural Reporting
Authors: Evans Parker T. , Nelson Scott D. , Wright Adam , Aher Chetan V.
Published: October 2024

Background While necessary and educationally beneficial, administrative tasks such as case and patient tracking may carry additional burden for surgical trainees. Automated systems targeting these tasks are scarce, leading to manual and inefficient workflows.

Methods We created an electronic health record (EHR)-based, user-specific dashboard for surgical residents to compile resident-specific data: bedside procedures performed, operative cases performed or participated in, and notes written by the resident as a surrogate for patients cared for. Usability testing was performed with resident volunteers, and residents were also surveyed postimplementation to assess for efficacy and satisfaction. Access log data from the EHR was used to assess dashboard usage over time. Descriptive statistics were calculated.

Results The dashboard was implemented on a population of approximately 175 surgical residents in 5 different departments (General Surgery, Obstetrics and Gynecology, Neurosurgery, Orthopaedics, and Otolaryngology) at a single academic medical center. Six resident volunteers participating in usability testing completed an average of 96% of preset tasks independently. Average responses to five questions extracted from the System Usability Scale (SUS) questions ranged from 4.0 to 4.67 out of 5. Postimplementation surveys indicated high resident satisfaction (4.39 out of 5) and moderate rates of use, with 46.4% of residents using the dashboard at least monthly. Daily use of the dashboard has increased over time, especially after making the dashboard a default for surgical residents.

Conclusion An EHR-based dashboard compiling resident-specific data can improve the efficiency of administrative tasks and supplement longitudinal education.
Drug-induced Liver Injury from Intravenous Immunoglobulin for Prevention of Recurrent Gestational Alloimmune Liver Disease: A Clinical Catch-22
Authors: Meyer Jessica A. , Silverstein Jenna S. , Thomas Kristen M. , Brubaker Sara G. , Chervenak Judith L.
Published: October 2024

Gestational alloimmune liver disease (GALD) is a rare autoimmune syndrome in which maternal antibodies lead to in utero fetal hepatocyte destruction, often presenting as neonatal liver failure and hemochromatosis. Antenatal intravenous immunoglobulin (IVIG) is generally accepted to be safe in pregnancy with demonstrable benefits for reducing GALD recurrence risk in subsequent pregnancies. Here we present a case of a 33-year-old woman with a prior neonatal demise due to GALD who received multiple prophylactic IVIG infusions in a subsequent twin pregnancy complicated by maternal jaundice and acute hepatitis. A liver biopsy demonstrated hepatocellular injury with bridging necrosis and cholestatic features consistent with drug-induced liver injury. This case demonstrates the importance of close clinical monitoring during IVIG therapy and the need for further research into alternative prophylaxis options for GALD.

Key Points
Off-Pump Revascularization in Moderate Ischemic Mitral Regurgitation
Authors: Ates Mehmet Sanser , Alptekin Gulen Sezer , Demirozu Zumrut Tuba , Zorman Yilmaz , Akcevin Atif
Published: October 2024

Background Ischemic mitral regurgitation (IMR) is associated with high mortality and poor outcomes. The surgical management of moderate IMR is still an object of debate.

Methods Patients with moderate IMR who underwent isolated off-pump coronary bypass grafting (OPCAB) with facile stabilization between January 2015 and February 2022 were analyzed. The primary endpoint was the remaining IMR and echocardiographic findings while the secondary outcomes were defined as mortality, major adverse events, and postoperative functional status.

Results Of 541 patients who underwent isolated OPCAB in this period, there were 62 patients with concomitant moderate IMR. The mean follow-up period was 19.4 ± 21.6 months. The median number of the coronary anastomosis was 4. In 58.06% (n = 36), the regurgitation regressed. Left atrial (LA) diameter significantly decreased postoperatively (p = 0.040). Increased LA diameter was associated with increased major adverse events (p = 0.010). Rehospitalization rates were higher in low ejection fraction (EF). The postoperative poor functional status (New York Heart Association [NYHA] III–IV) was correlated with an increased postoperative left ventricular end-systolic diameter (LVESD; 41.75 ± 6.13 vs. 34.79 ± 6.8 mm, p = 0.05). Mortality (4.8%, n = 3) was associated with older age and increased preoperative systolic pulmonary artery pressure (PAP; p = 0.050 and p = 0.046, respectively).

Conclusion LA diameter, LVESD, mean systolic PAP, left ventricular ejection fraction (LVEF), and age are important predictors for outcomes in IMR. Remaining IMR per se is not directly correlated with increased mortality and major adverse cardiac and cerebrovascular events. The facile stabilization technique we used appears to be advantageous due to the feasibility of full revascularization of all intended vessels, particularly of the inferoposterior wall by providing excellent vision without compression of the heart.