bluuebunny/crossref_metadata_2025 huggingface dataset:
Leucine encoding codon TTG shows an inverse relationship with GC content in genes involved in neurodegeneration with iron accumulation
Authors: Alqahtani Taha , Khandia Rekha , Puranik Nidhi , Alqahtani Ali M , Almikhlafi Mohannad A. , Algahtany Mubarak Ali
Published: January 2022

We determined various forces involved in shaping codon usage of the genes linked to brain iron accumulation and infantile neuroaxonal dystrophy. The analysis paved the way for determining the forces responsible for composition, expression level, physical properties and codon bias of a gene. An interesting observation related to composition was that, on all the three codon positions, any two of the four nucleotides had similar compositions. CpG, TpA, and GpT dinucleotides were underrepresented with the overrepresentation of TpG dinucleotide. CpG and TpA containing codons ATA, CTA, TCG, and GCG were underrepresented, while TpG dinucleotide containing codon CTG was overrepresented, indicative of compositional constraints importance. GC ending codons were favored when the genome is GC rich, except leucine encoding codon TTG, which exhibits an inverse relationship with GC content. Nucleotide disproportions are found associated with the physical properties of proteins. The values of CAI and ENc are suggestive of low codon bias in genes. Considering the results of neutrality analysis, parity analysis, underrepresentation of TpA and CpG codons, and over-representation of TpG codons, the correlation between the compositional constraints and skew relationships with protein properties suggested the role of all the three selectional, mutational and compositional forces in shaping codon usage with the dominance of selectional pressure.
Lip color affects ERP components in temporal face perception processing
Authors: Tanaka Hideaki
Published: January 2022

This brief report investigates the relationship between the lip color of women’s faces and the latency and amplitude of the P1, N170, and early posterior negativity of event-related potential components. To show different color lipsticks affect face perception processing, we used EEG to observe these event-related potential components in 19 participants exposed to visual stimuli under four conditions: red lips, yellow lips, blue lips, and no-makeup. The results indicate a significantly higher attractiveness score for red lips than the other three conditions and a significantly shorter P1 peak latency for red lips than blue lips or no-makeup. This may reflect that red lips attract attention more than blue or natural lips in the early stages of face processing. The results indicate that the peak of early posterior negativity for red lips occurred significantly longer than for yellow lips, blue lips, or no-makeup. Early posterior negativity amplitudes were significantly larger to red lips than blue lips or no-makeup. These results may indicate that, at later stages of face processing, the high attractiveness of red lips is associated with slower and careful processing. In contrast, blue lips, which have a low attractiveness score, are processed speedily and carelessly. These present results suggest a novel possibility that P1 and early posterior negativity can be used as a biomarker for temporal face perception processing of facial attractiveness in the human brain.
The role of selected postsynaptic scaffolding proteins at glutamatergic synapses in autism-related animal models
Authors: Meliskova Veronika , Havranek Tomas , Bacova Zuzana , Bakos Jan
Published: January 2022

Pathological changes in synapse formation, plasticity and development are caused by altered trafficking and assembly of postsynaptic scaffolding proteins at sites of glutamatergic and gamma-aminobutyric acid synapses, suggesting their involvement in the etiology of neurodevelopmental disorders, including autism. Several autism-related mouse models have been developed in recent years for studying molecular, cellular and behavioural defects to understand the etiology of autism and test potential treatment strategies. In this review, the role of alterations in selected postsynaptic scaffolding proteins in relevant transgene autism-like mouse models is explained. A summary is also provided of selected animal models by paying special attention to interactions between guanylate kinases or membrane-associated guanylate kinases, as well as other synapse protein components which form functional synaptic networks. The study of early developmental stages of autism-relevant animal models help in the understanding the origin and development of diverse autistic symptomatology.
Examining the association between traumatic brain injury and headache
Authors: Mofatteh Mohammad
Published: January 2022

Traumatic brain injury is a common and major cause of disability and death that might require emergency neurological and neurosurgical interventions. Traumatic brain injury can result in temporary or permanent physical, cognitive and psychological impairments. One of the most common complications associated with traumatic brain injury is post-traumatic headache, associated with significant disability and reduced quality of life. Post-traumatic headache is a public health concern that can affect the long-term outcome of traumatic brain injury patients. Clinical symptoms of post-traumatic headache significantly overlap with common primary headaches such as migraine and tension-type headaches. Beyond neurobiological factors, psychological factors can play crucial roles in the initiation and sustainment of post-traumatic headache. While neurological mechanisms underlying post-traumatic headache remains unknown, different studies suggest various mechanisms such as physical damages to the cranial nerves and neck structure, hyper-sensitization of the pain modulatory pathway, and inflammation as underlying causes for the neurobiology of headache. I explore the hypothesis that traumatic brain injury is associated with headaches. In particular, I provide an overview of the neurobiology of post-traumatic headache, its diagnosis, presenting recent findings on the etiology, explaining similarities and differences between with primary headaches such as migraine and tension-type headache, discuss pharmacological and non-pharmacological interventions for the treatments, as well as emphasising on the psychological importance of post-traumatic headache.
Near-infrared light spectroscopy and stimulation in cognitive neuroscience—the need for an integrative view?
Authors: Martini Matteo , Arias Natalia
Published: January 2022

Near-infrared spectroscopy has been largely used in neuroscience as an alternative non-invasive neuroimaging technique, primarily to measure the oxygenation levels of cerebral hemoglobin. Its portability and relative robustness against motion artifacts made it ideal for measuring cerebral blood changes during physical activity. Usually referred to as ‘functional’ near-infrared spectroscopy when used to monitor brain changes during motor or cognitive tasks, this technique often involves the montage of the probes on the forehead of the participants to gauge the neurophysiological underpinning of executive functioning. Other applications of near-infrared spectroscopy include other aspects of cerebral hemodynamics, such as cerebral pulsatility. More recently, it has been reported how near-infrared light can affect cognitive and psychological processes through what is known as photobiomodulation. However, ‘functional’ near-infrared spectroscopy studies do not seem to have taken this important bit of knowledge into account so far. Hence, drawing on a selection of near-infrared spectroscopy and photobiomodulation experiments, we suggest an integrative view for near-infrared-based neuroimaging studies, which should embrace a control for the possible effects of light stimulation, especially when ‘functional’ near-infrared spectroscopy is considered for testing the effect of an intervention.
Physicians' Satisfaction with The Service Quality of A Clinical Laboratory in Calapan City, Oriental Mindoro
Authors: Martin I Gregorio L. , Cawaling Bea Florence T. , Chumacera Danna M. , De Guzman Jethro Lorenzo G. , De Guzman Pamela Dorothy G. , De Vera Fer Cedrick T. , Navidad Florence
Published: January 2022

Clinical laboratory service assessment is essential in improving the quality of care and guaranteeing that quality standards are achieved. Physicians are their primary clients as physicians rely extensively on laboratory findings to make reliable diagnoses. Thus, the study aimed to assess physicians' satisfaction at a clinical laboratory in Calapan City, Oriental Mindoro, Philippines, based on the quality of service they provide, by identifying which factors greatly influence physicians' satisfaction and the physicians' concerns and recommendations. The laboratory accessibility, report format, information system, turnaround time, and service provision are the five factors evaluated in this study. A mixed-method approach was utilized wherein an online survey consisting of a 5-point Likert scale, and open-ended questions were deployed using Google forms and answered by 42 physicians. IBM SPSS Statistics 22 and the MAXQDA system were used to evaluate the responses. Overall, the physicians were satisfied with the clinical laboratory's services (X=3.9762). The laboratory report format has the most significant impact on physicians' overall satisfaction and is the factor with which physicians are most satisfied. Improvement of the turnaround time is advised. Future studies, including more laboratories and participants, are suggested.
Extra Virgin Olive Oil Nanoemulsion Attenuated Inflammatory Response in LPS-Induced Sepsis
Authors: Veterini Anna Surgean , Rehatta Nancy Margarita , Soedarmo Subijanto Marto , Rachmawati Heni , Widjiati Widjiati , P Widodo Jatim , Adi Annis Catur , Sudiana I Ketut
Published: January 2022

The provision of nutritional components in critical illness such as sepsis remains a big issue in clinical application, particularly through oral route due to intestinal integrity damaged-associated absorption problem. The aim of this research was to develop an EVOO nanoemulsion as a nutrient carrier to improve its permeability while maintaining intestinal mucosa integrity in a mouse model of LPS-induced endotoxemia. EVOO nanoemulsion was prepared by using the ultrasonication-mild agitation method. EVOO nanoemulsion (1.5 mL) was administered to the mice via an orogastric tube. The effect of EVOO nanoemulsion was evaluated by assessing the histopathological alterations in the lung, measuring the activation of NF?B-p65, the levels of circulating SP-D, TNF-?, IL-8, and IL-10. The main result, EVOO nanoemulsion decreased circulating SP-D level after 24h. In conclusion, EVOO nanoemulsion is a promising carrier to improve nutrient absorption and decrease circulating SP-D as an organ injury biomarker.
A practical case: features of the autoimmune insulin syndrome diagnosis
Authors: Zykova N. A. , Ignashina E. V. , Li E. D. , Kugryshev V. V.
Published: January 2022

Autoimmune Insulin syndrome (AIS), also named Hirata disease, is a rare condition characterized by hypoglycemic episodes due to the presence of high titers of insulin autoantibodies (IAA). AIS is a form of immune-mediated hypoglycemia, which develops when a triggering factor (medication or a viral infection) acts on an underlying predisposing genetic background. The diagnosis of IAS is challenging, requiring a careful workup aimed at excluding other causes of hyperinsulinemic hypoglucemia. The article presents a case of Hirata disease diagnosing of a patient of the therapy department of the Multidisciplinary Medical Center of the Bank of Russia.

Purpose: Determining of the features of the diagnosis of Autoimmune Insulin syndrome (Hirata disease)

Materials and methods: the article presents a clinical case of the diagnosis of Autoimmune insulin syndrome (Hirata disease), focuses on the diagnostic signiﬁcance of laboratory tests. The article is intended for general practitioners, endocrinologists, gastroenterologists.
Features of diagnosis and treatment of acute and chronic pancreatitis with primary hyperparathyroidism
Authors: Stjazhkina S. N. , Kotova I. V. , Zarivchatsky M. F. , Chernysheva T. E. , Ledneva A. V. , Baltachev I. A.
Published: January 2022

Aim: To identify a connection between acute and chronic pancreatitis and primary hyperparathyroidism on the base of clinical cases. To consider the features of the diagnosis and treatment of acute and chronic pancreatitis with primary hyperparathyroidism.

Materials and methods: Over the past 10 years, there have been observed 3 cases of pancreatitis with primary hyperparathyroidism. Two patients were diagnosed with chronic pancreatitis, one patient was diagnosed with acute destructive pancreatitis. Patients were undergoing surgery, parathyroidectomy was performed.

Results: Primary hyperparathyroidism is rarely associated with the occurrence of acute or chronic pancreatitis, but hypercalcemia plays an important role in the pathogenesis of these diseases. Pancreatitis usually occurs in the late stage of hyperparathyroidism, which explains the low prevalence of this association in developed countries, where primary hyperparathyroidism is diagnosed at an early stage of the disease.

Conclusion: These clinical cases of radical surgical treatment of parathyroid adenoma associated with severe concomitant pathology testiﬁes to the eﬀectiveness of the surgical method in some cases. It is necessary to take into account severe concomitant pathology and diagnose and correct it in time.
A brief review of clinical guidelines for the diagnosis and treatment of exocrine pancreatic insufficiency
Authors: Kucheryavyy Yu. A. , Bordin D. S.
Published: January 2022

In recent years, several consensus and guidelines for the diagnosis and treatment of chronic pancreatitis have been published. In 2017, the Russian and Pan-European (HaPanEU) consensus was published, in 2018 — the international consensus on minimal change pancreatitis, in 2020 — the clinical guidelines of the American College of Gastroenterology, in 2021 — the British clinical guidelines. Many of their provisions overlap. This review article analyzed the main provisions of the latest recommendations, taking into account the possibility of their adaptation to Russian clinical practice.
Is it necessary to correct the intestinal microbiota disorders in chronic pancreatitis?
Authors: Ardatskaya M. D. , Maslovskii L. V. , Zverkov I. V.
Published: January 2022

The frequency of intestinal microbiota disorders in patients with chronic pancreatitis (CP) is extremely high and can reach 97%. The bacterial overgrowth syndrome (SIBO) and the syndrome of increased epithelial permeability (SPEP), developing against the background of excretory insufficiency of the pancreas, affect the severity of the clinical picture of the disease, reduce the effectiveness of enzyme replacement therapy and generally contribute to the further progression of CP.

The article presents a modern view on the mechanisms of the formation of SIBO and SPEP in CP. There is their aggravating effect on the course of the disease and the aggravation of disorders of the digestive and absorption processes that accompany them is shown and analyzed in the article.

For decontamination of conditionally pathogenic and pathogenic ﬂora, increasing the number and metabolic activity of indigenous microﬂora in patients with CP, the use of a non-absorbable broad-spectrum antibiotic rifaximin is eﬀective. In order to restore the barrier function of the gastrointestinal mucosa, the drug of choice is rebamipid, a universal cytoprotector that affects all three levels of epithelial tissue protection (preepithelial, epithelial and subepithelial).

Conclusion. CP is characterized by the complexity of its etiology and pathogenesis. Bacterial factors, in particular, SIBO and SPEP, play an essential role in the development of inﬂammatory changes in the pancreas. In the complex therapy of CP, it is advisable to take measures aimed at correcting disorders of the intestinal microbiota.
Nutritional status disorders and methods of their correction in patients with advanced pancreatic cancer
Authors: Kiryukova M. A. , Dubtsova E. A. , Vinokurova L. V. , Malykh M. V. , Bordin D. S.
Published: January 2022

Despite of achieved progress in advanced pancreatic cancer treatment, the disease outcomes remain far from satisfying. The peculiarity of malnutrition treatment in these patients is the result of its causes complexity and progressively growing manifestations extent. The review represents mechanisms of malnutrition and approaches to their treatment.
Crown disease with extrainterinal manifestations in the form of granulematous alveolitis
Authors: Barlamov P. N. , Tretyakova Yu. I. , Zhelobov V. G. , Khlynova O. V.
Published: January 2022

Objective: To present a clinical description of the observation of a patient with Crohn’s disease (CD) with extraintestinal manifestations in the form of granulomatous alveolitis.

Materials and Methods: A brief review of the literature on the current understanding of the prevalence and clinical manifestations of lung lesions in inﬂammatory bowel diseases (IBD) and CD, as well as a description of a patient with this pathology with the results of autopsy is presented.

Results: The rare presence of granulomatous lung lesions in a patient with CD was proved.

Conclusion: Diﬃculties in the diﬀerential diagnosis and treatment of CD lung lesions are shown. In particular, suspicion of tuberculous lesion, lung abscess creates potential risks of generalization of the process when using such therapeutic eﬀects as glucocorticosteroids, cytostatics, immunosuppressants, biological genetically engineered drugs and active surgical intervention. The authors hope that the described observation will alert doctors in terms of possible systemic pulmonary lesions in CD.
Competition and forecasts for Nobel prize awards
Authors: MODIS THEODORE
Published: January 2022

The evolution of Nobel prize awards is studied as a learning/growing process. A simple logistic function describes the data well and accounts for the competition, be it between individuals or between nations. The American niche appears to be 64% exhausted by 1987, implying a diminishing expected rate of laureates in the future. Europeans have been losing ground continuously from the beginning while the remaining world has recently received more awards. Projections to the year 2000 and beyond are given. Correlations with age support the Darwinian nature of the competition for Nobel prizes. Awards to women show peaks coincidental with outbursts of feminism.
A Guide to Preprinting for Early Career Researchers
Authors: Ettinger Cassandra Lane , Sadanandappa Madhumala K. , Görgülü Kivanc , Coghlan Karen , Hallenbeck Kenneth K. , Puebla Iratxe
Published: January 2022

The use of preprints, research manuscripts shared publicly before the traditional peer-review process, is becoming more common in the life sciences. Early career researchers (ECRs) benefit from posting preprints as they are shareable, citable, and prove productivity. However, the decision to preprint a manuscript involves a discussion among all co-authors, and ECRs are often not the decision-makers. Therefore, ECRs may find themselves in situations where they are interested in posting a preprint but are unsure how to approach their co-authors or advisor about preprinting. Leveraging our own experiences as ECRs, and feedback from the research community, we have constructed a guide for ECRs who are considering preprinting - to enable them to take ownership over the process, and to raise awareness about preprinting options. We hope that this guide helps ECRs to initiate conversations about preprinting with co-authors and encourage them to preprint their future research.
Fractal aspects of natural growth
Authors: MODIS THEODORE
Published: January 2022

The work presented here puts forward a fractal aspect of natural growth. The S-shaped pattern of a logistic function is analyzed in terms of several constituent logistic functions. The approach sheds light on two familiar phenomena: the undulatory evolution of growth, which gives rise to an alternation between high-and low-growth periods, and the increasingly noticeable shrinking life cycle of products. There are some economic and political implications for the European nations. A quantitative example is given for computer sales from Digital Equipment Corporation. The approach is further generalized to suggest that any growth process can be analyzed in terms of natural-growth subprocesses. Applied to human growth this analysis yields precise definitions for the timing of transitions such as babyhood to childhood, and childhood to adolescence.
Innovation in the computer industry
Authors: MODIS THEODORE
Published: January 2022

A learning-curve approach has been employed to study inventiveness in the computer industry. The appearance of new models as well as the appearance of new computer manufacturers have been following typical logistic S-curves over the last 26 years of computer history. Innovation seems to come in S-waves, and even though many of today's major manufacturers are close to exhausting their maximum innovation potential in their present S-wave, the overall computer market is rather “young”. In contrast, the personal computer market is already beyond its maturity phase. Remarkably invariant over the 26 years considered, and through the complete range of computer sizes, remains the fact that for every five new computer models appearing on the market, there is one new computer company emerging also.
Chaoslike states can be expected before and after logistic growth
Authors: MODIS THEODORE
Published: January 2022

Instabilities associated with population growth can be simulated by putting the logistic growth curve in a discrete form. In contrast to the usual derivation of chaos, which can only explain instabilities at the top of the curve, this method can also account for fluctuations during the early phases of the niche-filling process. Precursors, a steep initial rise, and final instabilities can all be interrelated. Industrial examples are given of logistic growth alternating with periods of chaotic fluctuations.
Curiosity might not help after all: Predicted trajectories for need for cognition and anxiety and depression symptoms based on findings by Zainal and Newman (2022)
Authors: Sorjonen Kimmo , Nilsonne Gustav , Ingre Michael , Melin Bo
Published: January 2022

In a recent article, Zainal and Newman (2022) reported that need for cognition (NFC) predicted anxiety and depression symptoms (ADS) across 10 years in a large (N = 6750) sample of community-dwelling adults, and furthermore that a within-person decrease in NFC was associated with an increase in ADS. Here, we analyze the modeling approaches used in that paper, and show that the two different modeling strategies employed give contradictory results, suggesting that the results are influenced by statistical artifacts and should be interpreted with caution.
Tribute to Hari Saran Nepali (1943 – 2021 AD)
Authors: Thapa Tej Bahadur
Published: January 2022

NA
Українсько-польські синтаксичні паралелі у сучасних мовознавчих дослідженнях
Authors: Mahas Nataliya
Published: January 2022

Reviews of the latest research papers on the comparative syntax of Ukrainian and Polish languages are discussed in the article. The syntactic parallels in two languages are described in the monographic works of famous Slavicists. The analysis of scientific works on syntactic connections of Ukrainian and Polish languages is worked out in monographs, textbooks, numerous articles.
Петриківка – давній осередок витинанки в Україні
Authors: Kosytska Zinaida
Published: January 2022

While studying the Ukrainian folk art, it is important to explore artistic traditions of individual centres. The article considers traditional motifs and compositions of folk paper cutting art pieces, common in the village of Petrykivka (Dnipropetrovsk Region), an ancient core of paper cutting art. Such home paper decorations have become widespread in the centre since the late XIXth to early XXth centuries. Among the well-known masters – fellow villagers who created paper cutting art pieces were Vasyl Vovk, Pelaheya Hlushchenko, Hanna Hrechanova, Antonina Avdieyenko, Nataliya Avdieyenko and other masters. The auctorial paper cutting art pieces under study demonstrates the combination of deep traditions of folk art and personal aesthetic tastes of each of the artists, which determined each time a distinct unique style. It is important that they have been passing on their experience to next generations. It is important that modern masters continue to pass on their experience to next generations.
Afery polityczne w Republice Federalnej Niemiec. Przebieg, aktorzy, skutki
Authors: Gelles Katarzyna , Kozerski Mariusz , Trajman Joanna
Published: January 2022

A comprehensive study analysing the problem of political scandals in FRG from the political, historical, sociological and media perspective. The publication pinpoints the causes and the consequences of political scandals in the country established as a mature democracy with a well-functioning civil society. It analyses the influence such scandals exert on the political scene and stability in the country and shows the dynamics of political careers, linked to the mechanisms of scandalizing inappropriate behaviour of those participating in political life.
WAVELET DETAIL COEFFICIENT AS A NOVEL WAVELET-MFCC FEATURES IN TEXT-DEPENDENT SPEAKER RECOGNITION SYSTEM
Authors: Hidayat Syahroni , Muhammad Tajuddin  , Siti Agrippina Alodia Yusuf  , Jihadil Qudsi  , Jaya Nenet Natasudian
Published: January 2022

Speaker recognition is the process of recognizing a speaker from his speech. This can be used in many aspects of life, such as taking access remotely to a personal device, securing access to voice control, and doing a forensic investigation. In speaker recognition, extracting features from the speech is the most critical process. The features are used to represent the speech as unique features to distinguish speech samples from one another. In this research, we proposed the use of a combination of Wavelet and Mel Frequency Cepstral Coefficient (MFCC), Wavelet-MFCC, as feature extraction methods, and Hidden Markov Model (HMM) as classification. The speech signal is first extracted using Wavelet into one level of decomposition, then only the sub-band detail coefficient is used as the feature for further extraction using MFCC. The modeled system was applied in 300 speech datasets of 30 speakers uttering “HADIR” in the Indonesian language. K-fold cross-validation is implemented with five folds. As much as 80% of the data were trained for each fold, while the rest was used as testing data. Based on the testing, the system's accuracy using the combination of Wavelet-MFCC obtained is 96.67%.
ABSTRAK: Pengecaman penutur adalah proses mengenali penutur dari ucapannya yang dapat digunakan dalam banyak aspek kehidupan, seperti mengambil akses dari jauh ke peranti peribadi, mendapat kawalan ke atas akses suara, dan melakukan penyelidikan forensik. Ciri-ciri khas dari ucapan merupakan proses paling kritikal dalam pengecaman penutur. Ciri-ciri ini digunakan bagi mengenali ciri unik yang terdapat pada sesebuah ucapan dalam membezakan satu sama lain. Penyelidikan ini mencadangkan penggunaan kombinasi Wavelet dan Mel Frekuensi Pekali Cepstral (MFCC), Wavelet-MFCC, sebagai kaedah ekstrak ciri-ciri penutur, dan Model Markov Tersembunyi (HMM) sebagai pengelasan. Isyarat penuturan pada awalnya diekstrak menggunakan Wavelet menjadi satu tahap penguraian, kemudian hanya pekali perincian sub-jalur digunakan bagi pengekstrakan ciri-ciri berikutnya menggunakan MFCC. Model ini diterapkan kepada 300 kumpulan data ucapan daripada 30 penutur yang mengucapkan kata "HADIR" dalam bahasa Indonesia. Pengesahan silang K-lipat dilaksanakan dengan 5 lipatan. Sebanyak 80% data telah dilatih bagi setiap lipatan, sementara selebihnya digunakan sebagai data ujian. Berdasarkan ujian ini, ketepatan sistem yang menggunakan kombinasi Wavelet-MFCC memperolehi 96.67%.
POTENTIAL VOLUMIZING EFFECT OF THE POST-MORPH LIME FILLER IN ATTENUATING CONCRETE CARBONATION
Authors: Muhamad Hasif Hussin  , Wan Ibrahim Mohd Haziman , Othman Nor Hazurina , Mohammed Al-Fasih Mohammed Yahya , Arshad Mohd Fadzil
Published: January 2022

A study on the crystallography of the lime that comes from mussel shell has been conducted to determine the packing density of the material. The experimental analysis encompasses of concrete samples preparation with lime replacement at 5%, 7.5% and 10% by cement weight. The samples were carbonised naturally over a period of six months and subjected to the phenolphthalein test at 60, 90, 120 and 180 days. It has been found that lime originating from the mussel shell is of both the aragonitic and calcitic crystal types. Both crystal polymorphs of aragonite and calcite are denser than the typical normal concrete by 27.8% and 18.3% respectively. This suggest a volumizing effect that is beneficial to reduce carbonation penetration into the capillarity of the concrete. Results from the carbonation test indicate that concrete containing mussel shell lime ash showed up to 51% lower carbonation coefficient and significantly lower intensity of capillarity as shown via FESEM.
ABSTRAK: Kajian mengenai kristalografi kapur yang didapati daripada kulit kupang telah dijalankan bagi menentukan kepadatan bahan tersebut. Analisis eksperimen merangkumi penyediaan sampel-sampel konkrit yang mengandungi gantian kapur pada 5%, 7.5% dan 10% daripada berat simen. Sampel-sampel telah dikarbonatkan secara alami selama enam bulan dan menjalani ujian fenolftalin pada usia 60, 90, 120 dan 180 hari. Kajian telah mendapati bahawa kulit kupang terdiri daripada kapur-kapur berjenis aragonit dan kalsit. Kedua-dua polimorf kapur aragonit dan kalsit adalah 27.8% dan 18.3% lebih tumpat berbanding konkrit biasa. Hal ini berpotensi menjadi bahan penumpat yang bagus untuk mengurangkan serapan pengkarbonatan ke dalam kapilari konkrit. Keputusan ujian pengkarbonatan menunjukkan konkrit yang mengandungi abu kapur kulit kupang mempunyai pekali pengkarbonatan sehingga 51% lebih rendah dan mempunyai kerendahan kapilariti yang signifikan seperti yang ditunjukkan melalui FESEM.
FLOW INDUCED VIBRATION IN SQUARE CYLINDER OF VARIOUS ANGLES OF ATTACK
Authors: Ramzi Nur Ain Shafiza , Lee Kee Quen , MOHD ZAINURI NUR AMIRA BALQIS , KANG HOOI SIANG , OTHMAN NOR’AZIZI , WONG KENG YINN
Published: January 2022

An experimental study was carried out to identify the effect of angle of attack on flow-induced vibration (FIV) of square cylinders. The experiment was conducted at the Aeronautical and Wind Engineering Laboratory (AEROLAB), UTM Kuala Lumpur using a wind tunnel that was free from external wind conditions. A supporting structure was designed and fabricated to conduct this experiment. The importance of this support structure was to enable the rigid cylinder to suspend and vibrate freely upon excitation of wind speed. The results were analysed through the response of amplitude and frequency of the rigid cylinder over a velocity range of 0.5m/s to 4.0m/s. The results showed that for a square cylinder of ?=0°, vortex-induced vibration (VIV) occurred at low reduced velocity (UR) in range of 5 ? UR ? 10 and galloping occurred at higher reduced velocity which started at UR=15. A tranquil zone was found between VIV and galloping in the reduced velocity range of 10 ? UR ? 15. As for ?=22.5° and 45°, only VIV response was found at low reduced velocity in range of 4? UR ? 9.
ABSTRAK: Satu kajian eksperimentasi telah dilakukan bagi mengenal pasti pengaruh sudut serangan oleh getaran cetusan-aliran (FIV) dalam silinder persegi. Eksperimen ini dijalankan di Makmal Kejuruteraan Aeronautika dan Angin (AEROLAB), UTM Kuala Lumpur dengan menggunakan terowong angin yang bebas dari pengaruh angin luar. Struktur sokongan telah direka dan difabrikasi bagi tujuan eksperimen ini. Ini penting bagi membolehkan silinder pegun tergantung dan bergetar dengan bebas semasa ujian kelajuan angin. Dapatan kajian dianalisis melalui tindak balas amplitud dan frekuensi silinder pegun pada kadar halaju 0.5m/s sehingga 4.0m/s. Hasil kajian menunjukkan bahawa bagi silinder persegi ? = 0 °, getaran pengaruh-vorteks (VIV) berlaku pada halaju rendah (UR) dalam julat 5 ? UR ? 10 dan getaran lebih teruk telah ketara berlaku pada kadar halaju berkurang iaitu bermula pada UR = 15. Zon tenang dijumpai antara VIV dan getaran teruk pada kadar halaju berkurang 10 ? UR ? 15. Adapun pada ? = 22.5° dan 45°, hanya tindak balas VIV dijumpai pada halaju rendah dalam kadar 4? UR ? 9.
VEHICLE AIR CONDITIONER (VAC) CONTROL SYSTEM BASED ON PASSENGER COMFORT: A PROOF OF CONCEPT
Authors: Munahar Suroto , Purnomo Bagiyo Condro , Izzudin Muhammad , Setiyo Muji , Saudi Madihah Mohd
Published: January 2022

The air conditioning system (AC) in passenger cars requires precise control to provide a comfortable and healthy driving. In an AC system with limited manual control, the driver has to repeatedly change the setting to improve comfort. This problem may be overcome by implementing an automatic control system to maintain cabin temperature and humidity to meet passenger's thermal comfort. Therefore, this paper presents the development of a laboratory-scale prototype air conditioning control system to regulate temperature, humidity and air circulation in the cabin. The experimental results show that the control system is able to control air temperature in the range of 21 °C to 23 °C and cabin air humidity between 40% to 60% in various simulated environmental conditions which indicate acceptance for comfort and health standards in the vehicle. In conclusion, this method can be applied to older vehicles with reasonable modifications.
ABSTRAK: Sistem penyejuk udara (AC) pada kenderaan penumpang memerlukan ketepatan kawalan bagi menyediakan keselesaan dan kesejahteraan pemanduan. Melalui sistem AC dengan kawalan manual terhad, pemandu perlu berulang kali mengubah penyesuaian latar bagi meningkatkan keselesaan. Masalah ini dapat diatasi dengan menerapkan sistem kawalan automatik bagi menjaga suhu dan kelembapan kabin agar memenuhi keselesaan suhu penumpang. Oleh itu, kajian ini merupakan pembangunan prototaip sistem kawalan AC skala laboratari bagi mengawal suhu, kelembapan dan peredaran udara dalam kabin. Hasil eksperimen menunjukkan sistem kawalan ini mampu mengendali suhu udara pada kitaran 21 °C  hingga 23 °C dan kelembaban udara kabin antara 40% hingga 60% pada pelbagai keadaan persekitaran simulasi yang menunjukkan penerimaan standard keselesaan dan kesejahteraan kenderaan. Sebagai kesimpulan, cara ini dapat diaplikasi pada kenderaan lama dengan modifikasi bersesuaian.
COMPUTATIONLESS PALM-PRINT VERIFICATION USING WAVELET ORIENTED ZERO-CROSSING SIGNATURE
Authors: Chaudhari Jitendra , Mewada Hiren , Patel Amit , Mahant Keyur , Vala Alpesh
Published: January 2022

Palmprints can be characterized by their texture and the patterns of that texture dominate in a vertical direction. Therefore, the energy of the coefficients in the transform domain is more concentrated in the vertical sideband. Using this idea, this paper proposes the characterization of the texture features of the palmprint using zero-crossing signatures based on the dyadic discrete wavelet transform (DWT) to effectively identify an individual. A zero-crossing signature of 4 x 256 was generated from the lower four resolution levels of dyadic DWT in the enrolment process and stored in the database to identify the person in recognition mode. Euclidean distance was determined to find the best fit for query palmprints zero-crossing signature from the dataset. The proposed algorithm was tested on the PolyU dataset containing 6000 multi-spectral images. The proposed algorithm achieved 96.27% accuracy with a lower recognition time of 0.76 seconds.
ABSTRAK: Pengesan Tapak Tangan boleh dikategorikan berdasarkan ciri-ciri tekstur dan corak pada tekstur yang didominasi pada garis tegak. Oleh itu, pekali tenaga di kawasan transformasi adalah lebih penuh pada jalur-sisi menegak. Berdasarkan idea ini, cadangan kajian ini adalah berdasarkan ciri-ciri tekstur pada tapak tangan dan tanda pengenalan sifar-silang melalui transformasi gelombang kecil diadik yang diskret (DWT) bagi mengecam individu. Pada mod pengecaman, tanda pengenalan sifar-silang 4 x 256 yang terhasil daripada tahap diadik resolusi empat terendah DWT digunakan dalam proses kemasukan dan simpanan di pangkalan data bagi mengenal pasti individu. Jarak Euklidan yang terhasil turut digunakan bagi memperoleh padanan tapak tangan paling sesuai melalui tanda pengenalan sifar-silang dari set data.  Algoritma yang dicadangkan ini diuji pada set data PolyU yang mengandungi 6000 imej pelbagai-spektrum. Algoritma yang dicadangkan ini berjaya mencapai ketepatan sebanyak 96.27% dengan durasi pengecaman berkurang sebanyak 0.76 saat.
DETECTION OF TRAFFIC DENSITY WITH IMAGE PROCESSING USING PIN HOLE ALGORITHM
Authors: Irawanto Mochamad Aditya , Setianingsih Casi , Irawan Budhi
Published: January 2022

The intelligent traffic monitors are devloped and became more interst in recent years. A detection system in the monitoring traffic system is proposed using different algorithms. Pin Hole Algorithm used to detect the car that passes  the road (the studied area). A fixed camera mounted at predetermined point used with known height (of the camera), the intensity of the light, and the visibility of the camera. The classification process is important to know the traffic congestion status. The traffic congestion status will be sent to the server address already provided.  In the congestion detection test results were obtained with an accuracy value of 85% using the 64x64 grid division and obtaining good detection results for susceptible light intensity values between 5430 and 41379 LUX with an accuracy value of between 60% and 90%.
ABSTRAK: Sejak beberapa tahun ini, sistem pengawasan trafik pintar telah dibina dan terus berkembang luas. Sistem pengesanan dalam sistem trafik pengawasan telah dicadangkan menggunakan pelbagai algoritma. Algoritma lubang pin digunakan bagi mengesan kereta yang melalui jalan (kawasan kajian). Kamera dipasang tetap pada titik tertentu iaitu dengan menyelaras ketinggian kamera, keamatan cahaya, dan kebolehlihatan kamera. Proses klasifikasi sangat penting bagi menentukan status kesesakan trafik. Status kesesakan trafik akan dihantar ke alamat pelayan yang telah disediakan. Nilai ketepatan ujian pengesanan kesesakan yang diperoleh adalah 85% iaitu menggunakan pembahagi grid 64x64 dan dapatan kajian menunjukkan pengesanan yang baik bagi nilai keamatan cahaya antara 5430 dan 41379 LUX dengan nilai ketepatan antara 60% dan 90%.
Practical Approaches to Improving the Valuation of Territorial Communities Property
Authors:   Research Center for Forensic Examination on Intellectual Property of the Ministry of Justice of Ukraine, Tymoshchyk Liliia
Published: January 2022

Abstract. Introduction. The years of independence in Ukraine, which were marked by the establishment of a system of free market relations in the economy, were reflected, in particular, in the system of territorial governance. Many processes that were not present in the system of public property management, or were not considered important, now occupy a significant place in the process of effective management of municipal property - and the mechanism of property evaluation of the territorial community has become one of them. Purpose. The main purpose of the article is to study the priority areas for improving the efficiency of property valuation of territorial communities, in particular, real estate, in the modern economic system of Ukraine, as part of a system of effective management of public property. Results. The article considers a number of aspects that connect the system of community management in general and the mechanism of property assessment of territorial communities in particular. First of all, the priority measures of the management system, which require the creation of all conditions for the normal functioning of the community as a whole and each resident individually, have been analyzed, and the related concept of "maximum benefit" has been considered. An analysis of the views of various researchers on the characteristics and criteria for evaluating the activities of the management system and approaches to assessing the effectiveness of communal property, as relevant to assess the full value of the property of the local community. There are two levels of management system. The issues of effective real estate management have been considered and a number of concepts related to management in this area have been analyzed - "optimal use of real estate", "asset management" - and their significance in the context of the current economic and political situation has been analyzed. Conclusions. In the current economic situation and the tendency to change the size of territorial entities, when several different communities come together, the mechanism of property valuation of the territorial community becomes more common and acquires new importance in the management of public property. One of the main types of property valuation of a territorial community is real estate valuation, the importance of which grows with the number of property owners.
Ancient Audacity---Did Sages Past Subconsciously Speak Of Cellular Dust?
Authors: Seun Ayoade Mister
Published: January 2022

“Would it be too bold to imagine, that in the great length of time, since the earth began to exist, perhaps millions of ages before the commencement of the history of mankind, would it be too bold to imagine, that all warm-blooded animals have arisen from one living filament, which THE GREAT FIRST CAUSE endued with animality, with the power of acquiring new parts, attended with new propensities, directed by irritations, sensations, volitions, and associations; and thus possessing the faculty of continuing to improve by its own inherent activity, and of delivering down those improvements by generation to its posterity, world without end!
Can Chrono-Nutrition Help Prevent Diabetes?
Authors: Nikkhah Akbar
Published: January 2022

This editorial aimed to put forward a question if chrono-nutrition can help prevent diabetes through optimizing circadian rhythms of glucose metabolism. With the advancing mechanization, eating behavior (timing, sequence, and frequency) has changed. People are now more willing to eat fast foods at suboptimal times of the circadian period. Growing evidence suggests that untimely eating and lack of exercise can interfere with optimal physiological rhythms of glucose and insulin metabolism that can lead to diabetes. Type 2 diabetes mellitus (T2D) is a foremost metabolic disorder worldwide occurring largely due to suboptimal eating timing and lifestyle. Consuming less sugars and carbohydrates during evening and overnight may help optimize human chrono-physiology. Chrono-nutrition via optimizing the timing of meals is a growing science that needs to be well practiced to help prevent or possibly reduce risks of T2D in today’s complicated life.
Twins Cosmas and Damian – Patron Saints of Doctors
Authors: Malinowski Witold
Published: January 2022

Saint Luke is the one commonly believed to be a patron saint of physicians. The less known are Cosmas and Damian, the only twin physicians to have been declared saints in the Catholic Church. In Poland, we have been recently observing a growing interest in these saint twins. This is mainly associated with a return to the tradition of the Apothecary Feast, celebrated on September 26, the day of Cosmas’ and Damian’s martyr death.
Cancer and Virtual Reality Vr, the Great Challenge of The Century
Authors: BOULHART SAKHRI Selma épse
Published: January 2022

The number of new cases of cancer is constantly increasing around the world. The lengthening of life expectancy and therefore the aging of the population largely explain this increase in the number of cancers, in particular (prostate cancer in men, breast cancer in women, colorectal or gastric cancers)
Les spécificités de la gestion des opérateurs de l’État
Authors: Hernu Paul
Published: January 2022

Par leur nombre et leur taille, les opérateurs de l’État occupent une place significative dans les comptes nationaux. La diversité de leurs activités, de leur statut et de leurs sources de financement, parfois hors programmes budgétaires, complique l’exercice de la tutelle de l’État, d’autant que celle-ci est parfois plurielle et qu’elle peut se heurter à des opérateurs très autonomes dans l’action déconcentrée de l’État.
L’assistance de la Cour des comptes au Parlement et le rapport sur les relations entre l’État et ses opérateurs
Authors: Facon Flavien
Published: January 2022

La problématique des opérateurs de l’État a fait l’objet d’un rapport de la Cour des comptes sur sollicitation de l’Assemblée nationale. Bien que contribuant à éclairer ce sujet grâce à la synthèse opérée par la Cour, le rapport n’a pu en épuiser la complexité en raison des délais pesant sur la réalisation de cette étude.
Evaluation of Treatment Response in Lupus Nephritis
Authors:   „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, BOBIRCA Anca , BOBIRCA Florin ,   „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, FLORESCU Anca ,   „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, IORGUS Carmen ,   Department of Rheumatology, „Dr. I. Cantacuzino” Hospital, Bucharest, Romania, TINCA Radu ,   „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, MUSETESCU Anca ,   Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania, BOJINCA Mihai ,   „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, ANCUTA Ioan ,   „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: January 2022

Objectives: To evaluate the effectiveness of the treatment reflected by the rate of response to therapy at 6 months and 12 months of follow-up respectively. Methods: We retrospectively analyzed clinical, laboratory data, treatment regimens, the type of response and relapse rate of 51 patients diagnosed with LN between January 2017 and February 2020. Results:47.06% of the patients underwent renal biopsy, classes III and IV being the most common lupus nephritis types (totaling 35.3% of biopsied patients). All induction therapy choices analyzed in the study- CYC, Glucocorticoids (GCs) and MMF- proved effective at reducing the proteinuria of the patients (p=0.001, p=0.012 and p=0,019 respectively. The 12 months evaluation demonstrated an ascending trend of the complete response, starting from 27.45% at 6 months and almost doubling at 1 year (56.86%). Almost half of patients (49.02%) did not relapse, while most of them (27.45%) had only 1 relapse. Analyzing the risk of relapse for each induction drug used, CYC had the highest rate of recurrence (62.07%). The use of MMF as a maintenance drug associated the lowest degree of recurrence. Conclusions: Both CYC and MMF as induction therapy are significantly effective in reducing proteinuria. The complete response was more frequently identified as an endpoint at 12 months of follow-up.
UMA SEQUÊNCIA DIDÁTICA PARA O ENSINO DE MATRIZES
Authors: Farias Antonino de Araújo , Fialho Roberto Paulo Bibas
Published: January 2022

O intuito deste produto é oferecer aos professores, um material que norteie o trabalho com o assunto de Matrizes de forma mais dinâmica. A importância de se estudar o assunto de Matrizes é percebido não somente na Matemática, mas também em outras áreas como na Engenharia, na Medicina, na Química, na Física, na Economia, na Estatística, na Psicologia e outras. Neste trabalho, nos se preocupamos em mostrar a importância de estudar esse assunto na Educação Básica e no Ensino Superior. Este produto poderá beneficiar a atividade docente mediante a necessidade encontrada e alguns pontos que nos fizeram repensar o nosso fazer pedagógico. Como docente e um dos autores deste produto tive a oportunidade de ensinar o conteúdo de Matrizes no Ensino Médio, com o cuidado de mostrar a importância dele na série em questão e incluso no assunto de Geometria Analítica.