bluuebunny/crossref_metadata_2025 huggingface dataset:
Rehabilitation of Combined Hard and Soft Palate Defects with a Soft Relining Prosthesis: A Clinical Report
Authors: Yuan Zhi , Yuan Jingman , Wang Ziyuan , Rong Qiong
Published: August 2024

It remains a significant challenge in prosthetic rehabilitation for combined hard and soft palate defects on account of two primary reasons. At first, conventional impressions can hardly get an accurate analogue and usually bring about a terrible experience for the patients. Secondly, conventional hard denture base resins used in obturator prostheses exhibit limitations in marginal sealing, undercut retention, and elastic buffering when in contact with the soft palate. This article presents a case where combined hard and soft palate defects were successfully and rapidly reconstructed by using digital intraoral impression technology and denture soft reline material.
Primordial Odontogenic Tumor: A Review of the Literature and Report of Three New Patients
Authors: Cavalcante Israel Leal , Barros Caio César da Silva , Sousa Cruz Vitória Maria , Costa Mariana Bispo , da Silveira Santos Daniel Facó , de León-Garza Bernardo , Parra-Salazar Marco Antonio , Cruz-Tapia Roberto Onner , Rodriguez Brigitte , Manresa Carlos , Sánchez Gabriela , Villarroel-Dorrego Mariana , Turatti Eveline , Cavalcante Roberta Barroso , de Andrade Bruno Augusto Benevenuto
Published: August 2024

The primordial odontogenic tumor (POT) is a rare mixed odontogenic tumor composed of mesenchymal cells, columnar odontogenic epithelium, and fibromyxoid stroma affecting the posterior mandible of children and adolescents. Herein, we report 3 patients with POT and the clinicopathological features of POT previously reported in the literature. A 12-year-old, 19-year-old, and 4-year-old patient presented an asymptomatic swelling in the posterior maxilla and posterior mandible. Imaging exams revealed radiolucent lesions associated with unerupted teeth. The lesions were surgically removed, and the histopathological examination revealed spindle-to-ovoid mesenchymal cells in a fibromyxoid stroma surfaced by columnar odontogenic epithelial cells with reverse nuclear polarization. Deposition of mineralized tissue was observed. The final diagnosis was POT, and patients did not exhibit signs of recurrence. POT should be included in the differential diagnoses of intraosseous lesions in the posterior mandible in pediatric patients.
Validation of the RIETE, Kuijer, and HAS-BLED Models to Assess 3-Month Bleeding Risk in Anticoagulated Patients Diagnosed with Venous Thromboembolic Disease
Authors: Ortiz Gómez Stephanie , Ruiz-Talero Paula , Muñoz Oscar , Hoyos Pumarejo Luis Manuel
Published: August 2024

Objective

To evaluate the discriminative ability and calibration of the RIETE, Kuijer, and HAS-BLED models for predicting 3-month bleeding risk in patients anticoagulated for venous thromboembolism (VTE).

Methods

External validation study of a prediction model based on a retrospective cohort of patients with VTE seen at the Hospital Universitario San Ignacio, Bogotá (Colombia) between July 2021 and June 2023. The calibration of the scales was evaluated using the Hosmer-Lemeshow test and the ratio of observed to expected events (ROE) within each risk category. Discriminatory ability was assessed using the area under the curve (AUC) of a ROC curve.

Results

We analyzed 470 patients (median age 65 years, female sex 59.3%) with a diagnosis of deep vein thrombosis in most cases (57.4%), 5.7% bleeding events were observed. Regarding calibration, adequate calibration cannot be ruled out given the limited number of events. The discriminatory ability was limited with an area under the curve (AUC) of 0.48 (CI 0.37–0.59) for Kuijer Score, 0.58 (CI 0.47–0.70) for HAS-BLED and 0.64 (CI 0.51–0.76) for RIETE.

Conclusion

The Kuijer, HAS-BLED, and RIETE models in patients with VTE generally do not adequately estimate the risk of bleeding at three months, with a low ability to discriminate high-risk patients. Cautious interpretation is recommended until further evidence is available.
Prediction of remaining useful life for rolling bearing based on ISOMAP and multi-head self-attention with gated recurrent unit
Authors: Zhao Qiwu , Zhang Xiaoli
Published: August 2024

The remaining useful life of rolling element bearing affects the reliability and stability of the machine. Accurately predicting the remaining useful life of rolling element bearings is always necessary to make maintenance decisions in practical engineering. However, the remaining useful life prediction methods using traditional machine learning are incompetent for the task of training without labels, which consumes computational cost, financial resources, and labor. Therefore, a gated recurrent unit model based on feature dimensionality reduction and the multi-head self-attention mechanism (MHGRU) is established, and a homology algorithm is proposed to train the model and make the prediction. The isometric feature mapping algorithm and a homology algorithm are used in the model training, which incorporates the advantages of appreciable computational efficiency and preservation of automatic labeling for training in engineering. First, 24 basic features are extracted from the life-cycle vibration signals of rolling element bearings to reconstruct fusion features by the isometric feature mapping algorithm, which aims to reduce the feature dimension and improve computational efficiency. Since the multi-head self-attention mechanism in the MHGRU has the ability to comprehensively highlight the attention coefficient for long-term fusion features at different moments, it gives the gated recurrent unit considerable performance in reducing the computational complexity of extremely long time series and improving the accuracy of prediction results. In addition, two open-source IEEE PHM Challenge and XJTU-SY bearing datasets sampled by the sensor are adopted to assess the prediction performance of the MHGRU with homology algorithm. Finally, some existing remaining useful life prediction approaches of rolling element bearings are used for comparison. The experimental results show that MHGRU is suitable for the remaining useful life prediction of rolling element bearings and is superior to other models.
Immediate sequential bilateral cataract surgery: Prevalence, attitudes and concerns Among Italian ophthalmologists
Authors: Tavolato Marco , Modugno Rocco , Giglio Rosa , Inferrera Leandro , Tognetto Daniele
Published: August 2024

Purpose

to investigate the existing practice patterns of immediate sequential bilateral cataract surgery (ISBCS) in Italy and to assess ophthalmologists’ attitudes towards performing ISBCS in the future for cataract treatment.

Methods

It is a multicenter cross-sectional study. From February,1st 2023 to March, 1st 2023 the Members of the Italian Society of Cataract and Refractive Surgery (AICCER) as well as the attendees of its annual national congress were invited to anonymously complete an electronic 7-item questionnaire on their current ICBCS practice. Questions included the average number of procedures per month, the main indications for ICBCS, and the main reasons for performing and not performing ISBCS. Data were analyzed using descriptive statistics.

Results

of the 2300 recipients, 246 (10.7%) completed the survey. Of the respondents, 156 (63.4%) replied to perform ISBCS, most of them (82%) occasionally (1 to 5 procedures per month). Fifty-three percent (130 ophthalmologists) considered adopting ISBCS as routine practice in the near future. The conditions most considered for ISBCS were age-related cataract surgery under general and topical anesthesia and congenital cataract surgery. The availability of separate instruments for the two eyes as well as patient and hospital advantages were the most important reasons for performing ISBCS. The risk of bilateral endophthalmitis and medicolegal issues were the main reasons for not performing ISBCS.

Conclusions

ISBCS remains controversial among Italian surgeons, despite growing evidence of its safety and efficacy. The risk of potentially blinding complications such as bilateral endophthalmitis, together with medicolegal concerns are the principal barriers to ISBCS implementation in routine practice.
Intraoperative OCT to check the correct postimplant position of PreserfloTM
Authors: Morales-Fernández Laura , Pérez-García Pilar , Martínez-de-la-Casa José María , Sáenz-Francés Federico , Pascual-Santiago Marco-Antonio , Ginés-Gallego Cristina , García-Feijoo Julián
Published: August 2024

Introduction

This study was designed to examine the capacity of intraoperative optical coherence tomography (OCT) to predict the postimplant position of the glaucoma drainage device PreserfloTM.

Methods

13 eyes (mean age 65.42 (14.89) years) underwent PreserfloTM (Santen, Osaka, Japan) placement. Before surgery, participants were subjected to a comprehensive ophthalmic examination (intraocular pressure (IOP), cup to disk ratio (C/D), visual field, OCT, endothelial cell count). Anterior segment OCT scans were obtained intraoperatively using a Rescan 700 OCT system (Carl Zeiss Meditec, Inc., Oberkochen, Germany). One day postsurgery, anterior segment OCT using the Spectralis OCT (Heidelberg Engineering GmbH) was performed in a sitting position to capture the same chamber cross-section as before. The main outcome variables were tube-endothelium distance (T-E) and tube length (TL) in the anterior chamber measured using both OCT systems. Correlation between intraoperative and office measurements was examined through Pearson correlation (r) and intraclass correlation coefficients (ICC).

Results

Mean intraoperative and in-office T-E were 625.26 (SD 366.60) versus 561.16 (SD 364.62) µm respectively ( p = 0.540). Intraoperative and in-office anterior chamber TL were 1386 (SD 701.82) and 1433.91 (SD 713.55) µm, respectively ( p = 0.029). Excellent correlation was observed between both sets of T-E ( r = 0.992; p = 0.008) and TL ( r = 0.984; p = 0.016) values. Both OCT systems showed good agreement yielding ICCs of 0.992 ( p < 0.001) for T-E and 0.995 ( p = 0.001) for TL.

Discussion

Excellent correlation was observed between our intraoperative and postoperative OCT measurements. These results support the usefulness of intraoperative OCT to confirm the correct position of an implanted PreserfloTM microshunt.
Transorbital puncture for the treatment of cavernous sinus dural arteriovenous fistulas
Authors: Hughes Laura , Satchi Khami , Mitchell Peter , McNab Alan A , Hardy Thomas G
Published: August 2024

Background

Endovascular embolization of carotid-cavernous sinus dural arteriovenous fistulas (CCFs) is most commonly performed via a transfemoral-transvenous approach. Surgical cut-down of the superior ophthalmic vein is an alternative, well-described route. When these prove inaccessible, a transorbital approach can be used to reach the fistula.

Methods

We describe the recent experience- including indications, surgical technique, radiological findings and post-operative outcomes- in Melbourne of a series of patients in whom a percutaneous, transorbital direct puncture of the cavernous sinus enabled successful embolization of dural arteriovenous fistulas.

Results

Each of three patients achieved successful embolization of their CCFs via a transorbital puncture. Post-operatively, all patients experienced symptomatic relief with complete resolution of clinical signs secondary to their CCFs.

Conclusion

When angioarchitecture does not allow endovascular access, transorbital puncture of carotid-cavernous sinus dural arteriovenous fistulas can be a safe and effective technique. This report supports its success and low complication rate.
Making public or quiet listening? Media logics and public inquiries into the abuse of children
Authors: McCallum Kerry , Dreher Tanja , Deas Megan , de Souza Poppy , Joseph Samantha , Skogerbø Eli
Published: August 2024

This article examines the tensions between ‘publicness’ and ‘privacy’ in national commissions of inquiry. Through the insights of those who worked deep inside Australia's landmark Royal Commission into Institutional Responses to Child Sexual Abuse (RCIRCSA, 2013–2017), and the evidence provided in its final report, we explore the organisational and media logics of the Commission's highly publicised public hearings, and the ‘quiet’ institutional listening practices of its private sessions and engagement with marginalised communities. Royal Commissions are an important mechanism for raising awareness of past crimes on the public agenda. Our research finds that while the revelatory outcomes of the RCIRCSA have been well documented, its private sessions, engagement and research are less well understood. We argue ‘publicness’ is a relatively unchallenged good that is enacted through news media and the royal commission process, but media logics can limit their capacity to address the ongoing causes and impacts of child sexual abuse against the most impacted children. Participants reflected on the media logics that drove strategic decisions to ‘make public’ some cases and institutions, while others remained in the Commission's private realm. The article concludes that the confidential sharing of evidence has been undervalued in inquiry media studies that often centre the journalists’ role in uncovering and publicly revealing previously unheard stories. Drawing on international comparisons we find that while quiet listening risks negating the opportunity to amplify experience, it may also counter the potential silencing effects of unwanted public media scrutiny and protect potential witnesses from further harm.
Using Pre-operative Insulin Dose to Predict Diabetes Remission After Roux-En-Y Gastric Bypass and Sleeve Gastrectomy
Authors: Ghusn Wissam , Salameh Yara , Abi Mosleh Kamal , Shah Meera , Storm Andrew C. , Abu Dayyeh Barham K. , Ghanem Omar M.
Published: August 2024

Background

Obesity is intricately associated with type-2 diabetes (T2D) and other cardiovascular conditions, increasing morbidity, mortality, and health care costs. Metabolic and bariatric surgeries (MBS) have shown promising results in significant weight loss and T2D remission, but existing predictive scores for post-MBS diabetes remission do not consider insulin dosage, potentially overlooking a critical factor.

Methods

A retrospective analysis of patients with T2D who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). The study focused on insulin dosage impact, divided into quartiles, on remission rates post-MBS. The effectiveness of RYGB vs SG was compared within insulin dose quartiles with up to 5 years of follow up.

Results

A total of 508 patients (64% female, 94.9% White, mean age 53.5 ± 10.5 years, BMI (46.0 ± 8.3 kg/m2) were included in the analysis. This study demonstrates a profound association between insulin dosage quartiles and T2D remission after MBS. Patients with lower insulin requirements showed superior remission rates; those in the lowest quartile had remission rates of 73%, 70%, and 62% at 1, 3, and 5 years, respectively, compared to 34%, 37%, and 36% in the highest quartile ( P < 0.001 across all intervals). RYGB surgery showed a significantly better remission in the second and third insulin quartiles, suggesting its effectiveness over SG for patients with mid-range insulin requirements.

Conclusion

This study underscores the importance of considering insulin dosage when predicting T2D remission post-MBS. The findings advocate for a more nuanced selection of MBS procedures based on individual insulin profiles, potentially enhancing diabetes remission outcomes.
An overview of environmental risk factors for type 2 diabetes research using network science tools
Authors: Cao Xia , Yu Huixin , Quan Yu , Qin Jing , Zhao Yuhong , Yang Xiaochun , Gao Shanyan
Published: August 2024

Objective

Current studies lack a comprehensive understanding of the environmental factors influencing type 2 diabetes, hindering an in-depth grasp of the overall etiology. To address this gap, we utilized network science tools to highlight research trends, knowledge structures, and intricate relationships among factors, offering a new perspective for a profound understanding of the etiology.

Methods

The Web of Science database was employed to retrieve documents relevant to environmental risk factors in type 2 diabetes from 2012 to 2024. Bibliometric analysis using Microsoft Excel and OriginPro provided a detailed scientific production profile, including articles, journals, countries, and authors. Co-occurrence analysis was employed to determine the collaboration state and knowledge structures, utilizing social network tools such as Gephi, Tableau, and R Studio. Additionally, theme evolutionary analysis was conducted using SciMAT to offer insights into research trends.

Results

The publications and themes related to environmental factors in type 2 diabetes have consistently risen, shaping a well-established research domain. Lifestyle environmental factors, particularly diet and nutrition, stand out as the most represented and rapidly growing topics. Key focal hotspots include sedentary and digital behavior, PM2.5, ethnicity and socioeconomic status, traffic and greenspace, and depression. The theme evolutionary analysis revealed three distinct paths: (1) oxidative stress–air pollutants–PM2.5–air pollutants; (2) calcium–metabolic syndrome–cardiovascular disease; and (3) polychlorinated biphenyls (PCBs)–persistent organic pollutants (POPs)–obesity.

Conclusions

Digital behavior signifies a novel approach for preventing and managing type 2 diabetes. The influence of PM2.5 and calcium on oxidative stress and abnormal vascular contraction is intricately linked to microvascular diabetes complications. The transition from PCBs and POPs to obesity underscores the disruption of endocrine function by chemicals, elevating the risk of diabetes. Future studies should explore the connections between environmental factors, microvascular complications, and long-term outcomes in diabetes.
Unveiling the Nexus Between Crises, Investor Sentiment, and Volatility of Tourism-Related Stocks: Empirical Findings From Pakistan
Authors: Ullah Aziz , Biao He , Ullah Assad
Published: August 2024

This study investigates the predictive power of sentiment metrics concerning the volatility of tourism-related stocks listed on the Pakistan Stock Exchange (PSX) during recent crises. We employed univariate and multivariate GARCH-family econometric models to analyze daily data collected from March 2020 to April 2023. The data is categorized into two periods: A (COVID-19 until February 2022) and B (the vote of no-confidence motion until April 2023). The findings indicate that Market Sentiment (MS) plays a more significant role than individual sentiment in predicting stock price volatility and negatively impacts return volatility. During period A, the Fear Index (FI) and in B, economic policy uncertainty (EPU) were identified as factors contributing to increased fluctuation in tourism-related stocks. Additionally, MS exhibited a heightened level of bearishness compared to the COVID-19 era. The multivariate BEKK-GARCH analysis revealed that MS past volatility negatively spillover onto the current conditional volatility of PSX firms. This highlights the paramount importance of MS in understanding stock price fluctuations in the PSX. Interestingly, the technology sector exhibited lower sensitivity across the analysis. This study provides valuable insights for decision-makers by elucidating the principles of behavioral finance theory within the context of the PSX. They should prioritize long-term strategies to institutionalize investors, enhance their emotional intelligence, and mitigate psychological biases in the market.
Book review: R. Vaidyanathan. (2014). India Uninc
Authors: Paul Nabendu , Dutta Somnil
Published: August 2024

R. Vaidyanathan. (2014). India Uninc. Westland Publications, 372 pp., ₹371, ISBN: 9789383260560.
scMaui: a widely applicable deep learning framework for single-cell multiomics integration in the presence of batch effects and missing data
Authors: Jeong Yunhee , Ronen Jonathan , Kopp Wolfgang , Lutsik Pavlo , Akalin Altuna
Published: August 2024

The recent advances in high-throughput single-cell sequencing have created an urgent demand for computational models which can address the high complexity of single-cell multiomics data. Meticulous single-cell multiomics integration models are required to avoid biases towards a specific modality and overcome sparsity. Batch effects obfuscating biological signals must also be taken into account. Here, we introduce a new single-cell multiomics integration model, Single-cell Multiomics Autoencoder Integration (scMaui) based on variational product-of-experts autoencoders and adversarial learning. scMaui calculates a joint representation of multiple marginal distributions based on a product-of-experts approach which is especially effective for missing values in the modalities. Furthermore, it overcomes limitations seen in previous VAE-based integration methods with regard to batch effect correction and restricted applicable assays. It handles multiple batch effects independently accepting both discrete and continuous values, as well as provides varied reconstruction loss functions to cover all possible assays and preprocessing pipelines. We demonstrate that scMaui achieves superior performance in many tasks compared to other methods. Further downstream analyses also demonstrate its potential in identifying relations between assays and discovering hidden subpopulations.
Chimeric antigen receptor-T cells targeting epithelial cell adhesion molecule antigens are effective in the treatment of colorectal cancer
Authors: Zeng Siheng , Jin Ning , Yu Baofeng , Ren Qing , Yan Zhiqiang , Fu Songtao
Published: August 2024

Objective

To construct chimeric antigen receptor (CAR)-T cells targeting epithelial cell adhesion molecule (EpCAM) antigen (anti-EpCAM-CAR-T).

Methods

A third-generation CAR-T cell construct used a single-chain variable fragment derived from monoclonal antibody against human EpCAM. Peripheral blood mononuclear cells were extracted from volunteers. The proportion of cluster of differentiation 8 positive (CD8+) and CD4 + T cells was measured using flow cytometry. Western blot was used to detect the expression of EpCAM-CAR. The killing efficiency was detected using the MTT assay and transwell assay, and the secretion of killer cytokines tumour necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) was detected using the ELISA. The inhibitory effect of EpCAM-CAR-T on colorectal cancer in vivo was detected using xenografts.

Results

It was found that T cells expanded greatly, and the proportion of CD3+, CD8 + and CD4 + T cells was more than 60%. Furthermore, EpCAM-CAR-T cells had a higher tumour inhibition rate in the EpCAM expression positive group than in the negative group (P < 0.05). The secretion of killer cytokines TNF-α and IFN-γ in the EpCAM expression positive cell group was higher than that in the negative group (P < 0.05). In the experimental group treated with EpCAM-CAR-T cells, the survival rate of nude mice was higher (P < 0.05), and the tumour was smaller than that in the blank and control groups (P < 0.05). The secretion of serum killer cytokines TNF-α and IFN-γ in tumour-bearing nude mice in the experimental group treated with EpCAM-CAR-T cells was higher than that in the blank and control groups (P < 0.05).

Conclusion

This study successfully constructed EpCAM-CAR cells and found that they can target and recognise EpCAM-positive tumour cells, secrete killer cytokines TNF-α and IFN-γ and better inhibit the growth and metastasis of colorectal cancer in vitro and in vivo than unmodified T cells.
Trends and causes of maternal mortality in Indonesia: a systematic review
Authors: Syairaji M. , Nurdiati Detty Siti , Wiratama Bayu Satria , Prüst Zita D. , Bloemenkamp Kitty W. M. , Verschueren Kim J. C.
Published: August 2024

Background

The maternal mortality ratio (MMR) in Indonesia is among the highest in Southeast Asia. We aim to describe trends in the MMR and causes of maternal deaths in Indonesia over the past decades, regionally and nationally.

Methods

We performed a systematic review and conducted a search using PubMed, Embase, Global Health, CINAHL, Cochrane, Portal Garuda, and Google Scholar from the inception of the database to April 2023. We included all studies on the incidence and/or the causes of maternal deaths in Indonesia. The MMR was defined as the number of maternal deaths per 100,000 live births. Maternal death causes were assessed and reclassified according to the WHO International Classification of Disease Maternal Mortality (ICD-MM).

Results

We included 63 studies that reported the MMR (54 studies) and/or the causes of maternal deaths (44 studies) in Indonesia from 1970 to 2022, with a total of 254,796 maternal deaths. The national MMR declined from 450 to 249 (45%) between 1990 and 2020. Great differences in MMR exist across the country, with the lowest in Java-Bali and the highest (more than twice the national MMR) in Sulawesi and Eastern Indonesia. Between 1990 and 2022, the proportion of deaths due to hemorrhage and sepsis decreased, respectively from 48 to 18% and 15–5%, while the share of deaths due to hypertensive disorders and non-obstetric causes increased, respectively from 8 to 19% and 10–49%.

Conclusion

Despite the steady decline of maternal deaths in Indonesia, it remains one of the highest in Southeast Asia, with enormous disparities within the country. Hypertensive disorders and non-communicable diseases make up a growing share of maternal deaths, making maternal death reduction strategies increasingly challenging. National Maternal Death Surveillance and Response needs to be prioritized to eliminate preventable maternal deaths in Indonesia.

Registration of systematic reviews

PROSPERO, CRD42022320213.
Sedentary behaviors and physical activity of the working population measured by accelerometry: a systematic review and meta-analysis
Authors: Park Sungwon , Lee Sueyeon , Woo Seoyoon , Webster-Dekker Katelyn , Chen Weiyun , Veliz Philip , Larson Janet L.
Published: August 2024

Background

Too much sedentary behavior (SB) and too little physical activity (PA) place adult workers at risk for chronic illness. It remains unclear which occupations and subgroups within occupations have the highest and lowest SB and PA, and little is known about the effects of organizational factors on these behaviors and metrics. Thus, our main aims were to review and summarize evidence describing daily SB and PA collected using accelerometry across various occupations and to identify organizational factors influencing SB and PA.

Methods

A literature search of six databases was performed for relevant studies published through March 2023. Eligible studies were in English, targeted working populations, had a sample size > 75, and objectively measured both SB and PA for seven consecutive days using accelerometers. Following PRISMA guidelines, 5,197 studies were identified, and 19 articles met our inclusion criteria. Five of these studies were included in a meta-analysis comparing time spent in SB, light PA (LPA), and moderate to vigorous PA (MVPA) across occupations. Methodological quality was assessed using a Joanna Briggs Institute tool.

Results

We found that 63% of the studies reported daily time spent in SB and in MVPA, but fewer reported LPA, moderate PA, and vigorous PA. The average time spent in SB was 553.34 min/day, in LPA was 299.77 min/day, and in MVPA was 33.87 min/day. In occupational subgroup analysis, we observed that office workers had 2.3 h more SB, 2.4 less hours LPA, and 14 min less MVPA per day than nurses. However, most studies either did not specify workers’ occupations or grouped occupations. Shift work and workplace facilities significantly influenced SB and PA, but organizational factors affecting these behaviors were not sufficiently investigated (e.g., occupation type, work environment and workplace facilities, and shift work).

Conclusions

More research is needed to explore SB and PA patterns within occupational subgroups. Additionally, it is important to explore work-related individual (e.g., job task), interpersonal (e.g., social support from colleagues), organizational (e.g., work policy), and environmental factors influencing SB and PA. Future studies should also investigate the association of these factors with SB and PA.
Effect of hydrogen peroxide versus charcoal-based whitening mouthwashes on color, surface roughness, and color stability of enamel
Authors: Sultan Mayada S.
Published: August 2024

Background

Patients tend to favor the whitening mouthwashes as they are easily applied and affordable. This study aimed to evaluate the effect of hydrogen peroxide versus charcoal-based whitening mouthwashes on color, surface roughness, and color stability of enamel. In the current study, the whitening mouthwashes used have the ability to stop future stains due to their white seal technology.

Methods

A total of 21 permanent central incisor teeth extracted for periodontal reasons were used in the present study. Teeth roots were sectioned and crowns were mounted in self-cured acrylic resin blocks. The specimens were randomly divided into three groups (n = 7) according to the tested whitening mouthwash: Control group ‟ DW” (Distilled water), ‟OW” group: Peroxide-based mouthwash (Colgate Optic White) and ‟CP” group: Charcoal-based mouthwash (Colgate® Plax Charcoal). Regarding ‟OW” and ‟CP” groups, the specimens were immersed in 20 ml of the tested mouthwash in each corresponding group for 1 min twice daily (morning and evening) for a total of 12 uninterrupted weeks. Color change was assessed using VITA Easyshade spectrophotometer and surface roughness (Ra) was measured using a white light interferometer. The specimens were stained using black tea solution and color was measured after 24 h of immersion for assessment of color stability.

Results

Color change results revealed that both whitening mouthwashes were able to restore color comparable to the control group with no significant difference between them. Regarding surface roughness, the control group showed the highest mean Ra value, followed by ‟OW” group while ‟CP” group showed the lowest mean Ra value. While color stability after staining, the control group showed a significantly higher value than the ‟CP” and ‟OW” groups.

Conclusion

Hydrogen peroxide and charcoal-based whitening mouthwashes improve the color of enamel with no adverse effect on the surface roughness. Both whitening mouthwashes were beneficial to maintain the color after staining and prevent future enamel stains.
Empowering mind-body wellness: effect of bundling seated exercises and psychoeducational rehabilitation using the teach-back approach on fatigue and coping of women postmastectomy
Authors: Rashwan Zohour Ibrahim , Shaheen Samah Ramadan , Rasoul Ayah Shaban Abd-El Fattah Abd-El , Kamel Neama Mohamed Fouad , Darweesh Hamida Ahmed Mostafa
Published: August 2024

Background

Being diagnosed with Breast Cancer (BC) is a crisis that throws the patient’s life out of balance. Cancer-related fatigue is a debilitating sign experienced by women during and after BC treatment. Regular physical exercise may help mitigate patients’ fatigue, enhance coping abilities, improve their quality of life, and overall well-being. In parallel, psychological interventions are geared toward normalizing the lived painful experiences among oncology patients.

Objective

to examine the effect of bundling seated exercises and psychoeducational rehabilitation using the teach-back approach on fatigue and coping of women postmastectomy.

Methods

A quasi-experimental study was conducted in the Oncology Surgical Department and chemotherapy unit at the Alexandria Main University Hospital, Egypt. A total of 60 women were randomly allocated to either to the study or the control groups. Women in the study group practiced seated exercises and psychological rehabilitation interventions, including mindfulness breathing, problem-solving training, cognitive reframing technique, and thought stopping while the control group received the routine care.

Results

The study revealed a significant decline in the fatigue mean scores among participants in the intervention group from 136.10 ± 27.76 to 98.43 ± 25.99 (p < 0.001). Similarly, there was a significant decrease in the patients’ mean scores of maladaptive coping, helplessness/ hopelessness (p = 0.014), and anxious preoccupation (p = 0.008). In contrast, there is a noticeable increment in the scores of adaptive coping, such as fighting spirit (p = 0.012), cognitive avoidance (p = 0.002), and fatalism (p = 0.009).

Conclusion

Bundling seated exercises and psychological rehabilitation interventions using the teach-back approach have been proven to be simple and inexpensive non-pharmacological methods of reducing cancer-related fatigue and improving coping skills among women post-mastectomy.

Trial registration number

NCT06360276, ClinicalTrails.gov, Retrospectively registered (April 8th, 2024), URL of trial registry record: https://clinicaltrials.gov/ct2/show/NCT06360276.
Escape room design in training crew resource management in acute care: a scoping review
Authors: Jaspers Gerald J. , Borsci Simone , van der Hoeven Johannes G. , Kuijer-Siebelink Wietske , Lemson Joris
Published: August 2024

Background

Effective teamwork is crucial to providing safe and high-quality patient care, especially in acute care. Crew Resource Management (CRM) principles are often used for training teamwork in these situations, with escape rooms forming a promising new tool. However, little is known about escape room design characteristics and their effect on learning outcomes. We investigated the current status of design characteristics and their effect on learning outcomes for escape room-based CRM/teamwork training for acute care professionals. We also aimed to identify gaps in literature to guide further research.

Methods

Multiple databases were searched for studies describing the design and effect of escape rooms aimed training CRM/teamwork in acute care professionals and in situations that share characteristics. A standardized process was used for screening and selection. An evidence table that included study characteristics, design characteristics and effect of the escape room on learning outcomes was used to extract data. Learning outcomes were graded according to IPE expanded typology of Kirkpatrick’s levels of learning outcome and Medical Education Research Study Quality Instrument (MERSQI) scores were calculated to assess methodology.

Results

Fourteen studies were included. Common design characteristics were a team size of 4–6 participants, a 40-minute time limit, linear puzzle organization and use of briefing and structured debriefing. Information on alignment was only available in five studies and reporting on several other educational and escape room design characteristics was low. Twelve studies evaluated the effect of the escape room on teamwork: nine evaluated reaction (Kirkpatrick level 1; n = 9), two evaluated learning (Kirkpatrick level 2) and one evaluated both. Overall effect on teamwork was overtly positive, with little difference between studies. Together with a mean MERSQI score of 7.0, this precluded connecting specific design characteristics to the effect on learning outcomes.

Conclusions

There is insufficient evidence if and how design characteristics affect learning outcomes in escape rooms aimed at training CRM/teamwork in acute care professionals. Alignment of teamwork with learning goals is insufficiently reported. More complete reporting of escape rooms aimed at training CRM/teamwork in acute care professionals is needed, with a research focus on maximizing learning potential through design.
Translation and validation of the caregiving burden scale for family caregivers of children with cancer in chinese population
Authors: Xu Xinyi , Yu Yating , Tang Li , Chen Qiurong , Xie Shuai , Cen Yao , Zhang Xian , Min Lihua , Mao Xiaorong
Published: August 2024

Background

Effective response and reducing the burden of family care for children with cancer is critical, and China currently lacks a specific assessment tool.

Aims

This study aimed to translate and validate the Caregiving Burden Scale for Family Caregivers of Children with Cancer (CBSFC-CC) and then test and implement the tool.

Methods

According to the Beaton cross-cultural debugging guide, preliminary Chinese version of CBSFC-CC scale was formed, which was suitable for Chinese language environment and clinical context. Exploratory factor analyses (EFA) and confirmatory factor analyses (CFA) were performed to verify structural validity. Convergent validity, discriminant validity and reliability were also conducted.

Results

A total of 529 family caregivers of children with cancer participated in the survey. EFA extracts and combines four factors and explained 65.80% of the total variation. CFA proved that all the goodness-of-fit indicators were acceptable. The Cronbach’s alpha of the Chinese version of CBSFC-CC was .96, and the test–retest reliability coefficient was .95. Four dimensions and 29 items were identified in the final Chinese version of CBSFC-CC.

Conclusion

The chinese version CBSFC-CC is scientifically reasonable and has good reliability and validity, which can be applied to the investigation of the nursing burden of family caregivers of children with cancer in China.
Survival characteristics of Wilms Tumor, a reference developed from a longitudinal cohort study
Authors: Elgenidy Anas , Afifi Ahmed M. , Gad Eman F. , Atef Abdelsattar Ibrahim Hoda , khan Ubaid , Alomari Omar , Cheema Huzaifa A. , Ebad-Ur-Rehman Mohammad , Sherif Aya , Alzu’bi Mohammad , Abd-Elfattah Mohamed , Ahmad Ahmad Roshdy , Elhoufey Amira , Osman Amira M. , Ezzat Mohamed , Hammour Ahmed E. , Dailah Hamad Ghaleb , Gamal Doaa Ali , Saad Khaled
Published: August 2024

Background

Wilms tumor (WT) survival has been affected by the evolution in clinical and biological prognostic factors. Significant differences in survival rates indicate the need for further efforts to reduce these disparities. This study aims to evaluate the clinicopathological data impact on survival among patients after Wilm's diagnosis.

Methods

The study utilized the SEERStat Database to identify Wilms tumor patients, applying SEERStat software version 8.3.9.2 for data extraction. Selection criteria involved specific codes based on the International Classification of Diseases for Oncology (ICDO-3), excluding cases with unknown SEER stage, incomplete survival data, unknown size, or lymph node status. Statistical analyses, including Kaplan–Meier estimates and Cox regression models, were conducted using R software version 3.5. Standardized mortality ratios (SMR) were computed with SEER*Stat software, and relative and conditional survival analyses were performed to evaluate long-term survival outcomes.

Results

Of 2273 patients diagnosed with Wilms tumor, (1219 patients, 53.6% were females with an average age group of 3–8 years (50.2%). The overall mean survival after five years of diagnosis was 93.6% (2.6–94.7), and the overall mean survival rate was 92.5% (91.3–93.8) after ten years of diagnosis. Renal cancers were identified as the leading cause of death (77.3%), followed by nonrenal cancers (11%) and noncancer causes (11%). Additionally, robust relative survival rates of 98.10%, 92.80%, and 91.3% at one, five, and ten years, respectively, were observed, with corresponding five-year conditional survival rates indicating an increasing likelihood of survival with each additional year post-diagnosis. Univariate Cox regression identified significant prognostic factors: superior CSS for patients below 3 years (cHR 0.48) and poorer CSS for those older than 15 years (cHR 2.72), distant spread (cHR 10.24), regional spread (cHR 3.09), and unknown stage (cHR 4.97). In the multivariate model, age was not a significant predictor, but distant spread (aHR 9.22), regional spread (aHR 2.84), and unknown stage (aHR 4.98) were associated with worse CSS compared to localized tumors.

Conclusion

This study delving into WT survival dynamics reveals a multifaceted landscape influenced by clinicopathological variables. This comprehensive understanding emphasizes the imperative for ongoing research and personalized interventions to refine survival rates and address nuanced challenges across age, stage, and tumor spread in WT patients.
The mode of action of IL-23 in experimental inflammatory arthritic pain and disease
Authors: Lee Kevin M.-C. , Lupancu Tanya , Chang Leon , Manthey Carl L. , Zeeman Martha , Fourie Anne M. , Hamilton John A.
Published: August 2024

Objectives

We have previously reported using gene-deficient mice that the interleukin (IL)-23p19 subunit is required for the development of innate immune-driven arthritic pain and disease. We aimed to explore here, using a number of in vivo approaches, how the IL-23p19 subunit can mechanistically control arthritic pain and disease in a T- and B- lymphocyte-independent manner.

Methods

We used the zymosan-induced arthritis (ZIA) model in wild-type and Il23p19−/− mice, by a radiation chimera approach, and by single cell RNAseq and qPCR analyses, to identify the IL23p19-expressing and IL-23-responding cell type(s) in the inflamed joints. This model was also utilized to investigate the efficacy of IL-23p19 subunit blockade with a neutralizing monoclonal antibody (mAb). A novel IL-23-driven arthritis model was established, allowing the identification of putative downstream mediators of IL-23 in the control of pain and disease. Pain and arthritis were assessed by relative static weight distribution and histology, respectively.

Results

We present evidence that (i) IL-23p19+ non-bone marrow-derived macrophages are required for the development of ZIA pain and disease, (ii) prophylactic and therapeutic blockade of the IL-23p19 subunit ameliorate ZIA pain and disease and (iii) systemically administered IL-23 can induce arthritic pain and disease in a manner dependent on TNF, GM-CSF, CCL17 and cyclooxygenase activity, but independently of lymphocytes, CGRP, NGF and substance P.

Conclusions

The data presented should aid IL-23 targeting both in the choice of inflammatory disease to be treated and the design of clinical trials.
The impact of the COVID-19 lockdown on social and economic welfare in Uganda
Authors: Musoke David , Nalinya Sarah , Lubega Grace Biyinzika , Deane Kevin , Ekirapa-Kiracho Elizabeth , McCoy David
Published: August 2024

Background

As a measure to slow down the transmission of Coronavirus disease (COVID-19), governments around the world placed their countries under various stringent lockdown measures. Uganda is one of the countries that had a strict lockdown in Africa. This qualitative study explored the social and economic impacts of the COVID-19 lockdown in both an urban (Kampala) and rural (Wakiso) setting in Central Uganda.

Methods

The study used focus group discussions (FGDs), household interviews, and key informant interviews (KIIs). 14 FGDs were conducted among several stakeholders including community health workers, health professionals, and members of the community. 40 household interviews were conducted among low, middle, and high-income households, while 31 KIIs were held among policy makers, non-governmental organisations, and the private sector. Data were analysed thematically in NVivo 2020 (QSR International).

Results

Findings from the study are presented under six themes: family disruption; abuse of children’s rights; disruption in education; food insecurity; impact on livelihoods; and violation of human rights. The study found that the COVID-19 lockdown led to family breakups, loss of family housing, as well as increased both caring responsibilities and gender-based violence especially towards females. Children’s welfare suffered through increased child labour, sexual exploitation, and early marriages. The extended closure of schools led to delayed educational milestones, poor adaptation to home-based learning, and increased school drop-out rates. Increased food insecurity led to changes in feeding patterns and reduced food varieties. Livelihoods were negatively affected hence people depleted their savings and capital. Unlawful detention and beating by law enforcement officers increased during the lockdown.

Conclusion

Future pandemic planning needs to consider the consequences of lockdown on the social and economic wellbeing of communities hence put in place appropriate mitigation measures during and after the outbreak.
Exploring the impact of high density planting system and deficit irrigation in cotton (Gossypium hirsutum L.): a comprehensive review
Authors: Manibharathi Sekar , Somasundaram Selvaraj , Parasuraman Panneerselvam , Subramanian Alagesan , Ravichandran Veerasamy , Manikanda Boopathi Narayanan
Published: August 2024

Lessons learned from past experiences push for an alternate way of crop production. In India, adopting high density planting system (HDPS) to boost cotton yield is becoming a growing trend. HDPS has recently been considered a replacement for the current Indian production system. It is also suitable for mechanical harvesting, which reducing labour costs, increasing input use efficiency, timely harvesting timely, maintaining cotton quality, and offering the potential to increase productivity and profitability. This technology has become widespread in globally cotton growing regions. Water management is critical for the success of high density cotton planting. Due to the problem of freshwater availability, more crops should be produced per drop of water. In the high-density planting system, optimum water application is essential to control excessive vegetative growth and improve the translocation of photoassimilates to reproductive organs. Deficit irrigation is a tool to save water without compromising yield. At the same time, it consumes less water than the normal evapotranspiration of crops. This review comprehensively documents the importance of growing cotton under a high-density planting system with deficit irrigation. Based on the current research and combined with cotton production reality, this review discusses the application and future development of deficit irrigation, which may provide theoretical guidance for the sustainable advancement of cotton planting systems.
Change management through strategic leadership: the mediating effect of knowledge management in public organizations, Ethiopia
Authors: Ferede Worku Lemlemu , Endawoke Yalew , Tessema Gedif
Published: August 2024

The purpose of this study is to investigate the effects of strategic leadership on change management within public organizations, mediated by knowledge management. In this study, an explanatory design and a quantitative approach were employed. A structured questionnaire survey was administered to 366 randomly selected respondents from public organizations in northwest Ethiopia. The reliability and validity of the scale items were rigorously assessed, and the data were analyzed using partial least squares structural equation modeling. The findings reveal the direct effects of strategic leadership and knowledge management on change management, with knowledge management partially mediating the relationship between strategic leadership and change management. The study addresses a significant gap in the literature by shedding light on how strategic leadership drives change in public organizations. Its interdisciplinary approach and examination of mediation offer original insights, paving the way for future studies on challenges within public service contexts. Recommendations underscore the importance of considering local context, embracing adaptive leadership, and integrating knowledge processes for effective change management in public organizations.