bluuebunny/crossref_metadata_2025 huggingface dataset:
Bright Lu2O3:Eu Thin‐Film Scintillators for High‐Resolution Radioluminescence Microscopy
Authors: Sengupta Debanti , Miller Stuart , Marton Zsolt , Chin Frederick , Nagarkar Vivek , Pratx Guillem
Published: July 2015

The performance of a new thin‐film Lu2O3:Eu scintillator for single‐cell radionuclide imaging is investigated. Imaging the metabolic properties of heterogeneous cell populations in real time is an important challenge with clinical implications. An innovative technique called radioluminescence microscopy has been developed to quantitatively and sensitively measure radionuclide uptake in single cells. The most important component of this technique is the scintillator, which converts the energy released during radioactive decay into luminescent signals. The sensitivity and spatial resolution of the imaging system depend critically on the characteristics of the scintillator, that is, the material used and its geometrical configuration. Scintillators fabricated using conventional methods are relatively thick and therefore do not provide optimal spatial resolution. A thin‐film Lu2O3:Eu scintillator is compared to a conventional 500 μm thick CdWO4 scintillator for radioluminescence imaging. Despite its thinness, the unique scintillation properties of the Lu2O3:Eu scintillator allow us to capture single‐positron decays with fourfold higher sensitivity, which is a significant achievement. The thin‐film Lu2O3:Eu scintillators also yield radioluminescence images where individual cells appear smaller and better resolved on average than with the CdWO4 scintillators. Coupled with the thin‐film scintillator technology, radioluminescence microscopy can yield valuable and clinically relevant data on the metabolism of single cells.
Diastereoselective Oxidative CN/CO and CN/CN Bond Formation Tandems Initiated by Visible Light: Synthesis of Fused N‐Arylindolines
Authors: Morris Scott A. , Nguyen Theresa H. , Zheng Nan
Published: July 2015

The synthesis of fused N‐arylindolines using visible light photoredox catalysis has been developed. We previously described that photogenerated amine radical cations generate substituted indoles through an intermediate benzylic carbocation. Herein, we expand the application of this chemistry by trapping the benzylic carbocation with tethered heteronucleophiles. The reactivity of the photogenerated benzylic carbocation is explored and applied to a range of substrates with various electronic characters and ring constraints. The method described provides C‐2 and C‐3 fused indolines bearing a tetrasubstituted carbon stereocenter with greater than 99:1 diastereoselectivity in moderate to good yields.

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Quantitative physical activity assessment of children and adolescents in a rural population from Eastern Nepal
Authors: Williams Kimberly D. , Subedi Janardan , Jha Bharat , Blangero John , Williams‐Blangero Sarah , Towne Bradford
Published: July 2015

Objectives

We report cross‐sectional, objectively measured physical activity data for 399 children and adolescents aged 6 to 18 years. We evaluated physical activity of children and adolescents, considered time spent in each activity intensity category, and explored the impact of growth disruption (stunting and wasting) on physical activity patterns.

Methods

Participants wore an Actical (Mini‐Mitter, Bend, OR) omnidirectional accelerometer for one week as part of their annual visit to the Jiri Growth Study. The percentage of time spent in standard activity intensities were computed using standard metabolic equivalents (METS) cutpoints and compared by chronological age, sex, and school versus non‐school days.

Results

Primary findings include (1) children are more active on non‐school days and adolescents are more active during the school week; (2) Jirel children do not exhibit the reduction in physical activity that most Western populations experience during the transition from childhood to adolescence; and (3) Jirel children and adolescents routinely meet the suggested one hour/day MVPA threshold; (4) Stunting is prevalent and factors leading to this growth disruption may contribute to the amount of time in sedentary or light physical activity.

Conclusions

We report child and adolescent physical activity patterns from the Jirel population of eastern Nepal. In this rural context, children and adolescents are more active than populations reported from Western contexts. This key finding has important biomedical implications for the maintenance of healthy body composition, skeletal health, and other health traits. Am. J. Hum. Biol. 28:129–137, 2016. © 2015 Wiley Periodicals, Inc.
Body mass index and waist circumference are not good surrogate indicators of adiposity in psychogeriatric patients
Authors: Camina Martín Ma Alicia , De Mateo Silleras Beatriz , Miján De La Torre Alberto , Barrera Ortega Sara , Domínguez Rodríguez Luis , Redondo Del Río Ma Paz
Published: July 2015

Objective

to assess the utility of body mass index (BMI) and waist circumference (WC) as surrogate indicators of adiposity with respect to the total body fat estimated with bioimpedance analysis in psychogeriatric patients.

Methods

Anthropometric and hand‐to‐foot bioimpedance measurements were performed according to standard procedures in a sample of 128 psychogeriatric patients (87 males, 41 females). WC cutoffs proposed by the International Diabetes Federation were used to define abdominal obesity. Z‐scores of fat and fat‐free mass indices (Z‐FMI and Z‐FFMI) were calculated.

Results

Males with WC values below the cutoff were normal weight, and showed normal levels of FM and low FFM (Z‐FFMI below 1.5 SD). Males with WC values above the cutoff were overweight, showed high levels of FM (Z‐FMI: 1.34 SD) and a slight depletion of FFM (Z‐FFMI: −0.59 SD). In females with WC values below the cutoff, BMI was close to 20 kg/m2 and both FM and FFM were depleted (Z‐FMI: −0.7 SD; Z‐FFMI: −1.76 SD). In females with WC above the cutoff, the average BMI was 25.6 kg/m2, Z‐FMI was 0.48 SD, and Z‐FFMI was −0.56 SD.

Conclusions

Our results indicate that it is necessary to establish age and sex‐specific BMI and WC cutoffs, and also highlight the importance of focusing on body composition analysis to ensure an accurate nutritional diagnosis in older‐adults and in psychogeriatric patients. Am. J. Hum. Biol. 28:233–235, 2016. © 2015 Wiley Periodicals, Inc.
Gene‐set and multivariate genome‐wide association analysis of oppositional defiant behavior subtypes in attention‐deficit/hyperactivity disorder
Authors: Aebi Marcel , van Donkelaar Marjolein M. J. , Poelmans Geert , Buitelaar Jan K. , Sonuga‐Barke Edmund J. S. , Stringaris Argyris , consortium IMAGE , Faraone Stephen V. , Franke Barbara , Steinhausen Hans‐Christoph , van Hulzen Kimm J. E.
Published: July 2015

Oppositional defiant disorder (ODD) is a frequent psychiatric disorder seen in children and adolescents with attention‐deficit‐hyperactivity disorder (ADHD). ODD is also a common antecedent to both affective disorders and aggressive behaviors. Although the heritability of ODD has been estimated to be around 0.60, there has been little research into the molecular genetics of ODD. The present study examined the association of irritable and defiant/vindictive dimensions and categorical subtypes of ODD (based on latent class analyses) with previously described specific polymorphisms (DRD4 exon3 VNTR, 5‐HTTLPR, and seven OXTR SNPs) as well as with dopamine, serotonin, and oxytocin genes and pathways in a clinical sample of children and adolescents with ADHD. In addition, we performed a multivariate genome‐wide association study (GWAS) of the aforementioned ODD dimensions and subtypes. Apart from adjusting the analyses for age and sex, we controlled for “parental ability to cope with disruptive behavior.” None of the hypothesis‐driven analyses revealed a significant association with ODD dimensions and subtypes. Inadequate parenting behavior was significantly associated with all ODD dimensions and subtypes, most strongly with defiant/vindictive behaviors. In addition, the GWAS did not result in genome‐wide significant findings but bioinformatics and literature analyses revealed that the proteins encoded by 28 of the 53 top‐ranked genes functionally interact in a molecular landscape centered around Beta‐catenin signaling and involved in the regulation of neurite outgrowth. Our findings provide new insights into the molecular basis of ODD and inform future genetic studies of oppositional behavior. © 2015 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.
A Chemical Route Towards Single‐Phase Materials with Controllable Photoluminescence
Authors: Kaur Behrh Gaganpreet , Serier‐Brault Hélène , Jobic Stéphane , Gautier Romain
Published: July 2015

A promising general approach is proposed that enables the controlled reduction of dopants to tune the photoluminescence properties of single‐phase materials. The change of oxidation state of dopants in phosphor phases leads to different emission colors that can be finely tuned. This approach was illustrated with the progressive reduction of the red phosphor SrAl2O4:Eu3+ to green phosphor SrAl2O4:Eu2+ to target yellow luminescence.
Batch foaming poly(vinyl alcohol)/microfibrillated cellulose composites with CO2 and water as co‐blowing agents
Authors: Zhao Na , Zhu Changwei , Howe Mark Lun , Park Chul B. , Li Qian
Published: July 2015

We studied the foaming behavior of poly(vinyl alcohol) (PVOH) and microfibrillated cellulose (MFC) composites in a batch process using supercritical carbon dioxide (scCO2) and water as co‐blowing agents. In PVOH/MFC composites, water is an economical plasticizer. It not only suppresses the potential thermal degradation of PVOH but also extends the processing window. A uniform cell structure and a high cell density were achieved in the PVOH/MFC foams. The results showed that cell density was increased by increased water content. Further, the MFC contained both micro‐ and nano‐sized fibers. These created numerous heterogeneous nucleation sites and caused local pressure variations. However, cell density decreased when the MFC was overdosed. Due to the high crystallinity that then developed around the MFC, the gas content was too low, and the stiffness was too high. The experimental results also showed that the cell morphology and density could both be controlled by the water and the MFC content. The effects of the foaming temperature and pressure on the cellular morphology of the PVOH/MFC composite foams were examined systematically. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42551.
Fabrication of cellulose acetate ultrafiltration membrane with diphenyl ketone via thermally induced phase separation
Authors: Pang Bo , Li Qian , Tang Yuanhui , Zhou Bo , Liu Tianyin , Lin Yakai , Wang Xiaolin
Published: July 2015

With diphenyl ketone as diluent, cellulose acetate (CA) ultrafiltration (UF) membrane with a bicontinuous structure was prepared via thermally induced phase separation (TIPS) method. The liquid–liquid phase separation region of CA/diphenyl ketone system was measured and the maximum corresponding polymer concentration was approximately 53 wt %. The effects of polymer concentration, coarsening time and coarsening temperature on the morphologies, and mechanical properties of CA membranes were investigated systematically. As the polymer concentration increased from 15 to 30 wt %, the bicontinuous structure could be obtained and the tensile strength of CA membranes increased from 3.92 to 30.17 MPa. With the increase of coarsening time, the thickness of dense skin layer and the asymmetry of cross‐section reduced. However, excess coarsening rendered the membrane morphology evolved from a bicontinuous structure to a cellular structure. When the coarsening time was 5 min, the bicontinuous structure in cross‐section showed good interconnectivity and the dense skin layer exhibited a thin thickness of 2 μm. The fabricated CA hollow fiber UF membrane exhibited a high tensile strength of 31.00 MPa and rejection of 96.10% for dextran 20 kDa. It is indicated that diphenyl ketone is a competitive diluent to prepare CA membranes with excellent performance via TIPS. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42669.
Direct Synthesis of Controlled‐Size Nanospheres inside Nanocavities of Self‐Organized Photopolymerizing Soft Oxometalates [PW12O40]n (n=1100–7500)
Authors: Das Kousik , Roy Soumyajit
Published: July 2015

The unusual self‐assembly of {(BMIm)2(DMIm)[PW12O40]}n (n=1100–7500) (BMIm=1‐butyl‐3‐methylimidazolium, DMIm=3,3′‐dimethyl‐1,1′‐diimidazolium) soft oxometalates (SOMs) with controlled size and a hollow nanocavity was exploited for the photochemical synthesis of polymeric nanospheres within the nanocavity of the SOM. The SOM vesicle has been characterized by using several techniques, including dynamic light scattering (DLS), static light scattering (SLS), attenuated total reflection (ATR) IR spectroscopy, Raman spectroscopy, microscopy, and zeta‐potential analysis. The self‐assembly and stabilization of this soft‐oxometalate vesicle has been shown by means of counter‐ion condensation. The immediate implication of such stabilization—the variation of the dielectric constant with the hydrodynamic radius of the vesicle—has been used to synthesize vesicles of controlled size. Such vesicles of varying size have been used as templates for polymerization reactions that produce polymeric spheres of controlled size. Direct evidence shows that the SOM behaves as a model heterogeneous catalytic system. Such surfactant‐ and initiator‐free photochemical synthetic routes for obtaining uniform latex spheres could be used in the making of optical bandgap materials, inverse opals, and paints.
Investigation on Luminescence Properties of a Long Afterglow Phosphor Ca2SnO4:Tm3+
Authors: Li Hai‐Feng , Sun Wen‐Zhi , Jia Yong‐Lei , Ma Teng‐Fei , Fu Ji‐Peng , Li Da , Zhang Su , Jiang Li‐Hong , Pang Ran , Li Cheng‐Yu
Published: July 2015

A series of new long afterglow phosphors Ca2SnO4:x Tm3+ were synthesized by using traditional solid‐state reactions. XRD measurements and Rietveld refinement revealed that the incorporation of the Tm3+ dopants generated no second phase other than the original one of Ca2SnO4, which indicated that the dopants completely merged into the host. The corresponding optical properties were further systematically studied by photoluminescence, phosphorescence, and thermoluminescence (TL) spectroscopy. The results show that the Tm3+‐related defects account for the bright bluish green afterglow emission from the characteristic f–f transitions of Tm3+ ions. The bluish green long‐lasting phosphorescence could be observed for 5 h by the naked eye in a dark environment after the end of UV irradiation. Two TL peaks at 325 and 349 K from the TL curves were adopted to calculate the depth of the traps, which were 0.45 and 0.78 eV, respectively. The mechanism of the long afterglow emission was also explored.
Facile and Divergent Synthesis of Lamellarins and Lactam‐Containing Derivatives with Improved Drug Likeness and Biological Activities
Authors: Theppawong Atiruj , Ploypradith Poonsakdi , Chuawong Pitak , Ruchirawat Somsak , Chittchang Montakarn
Published: July 2015

With the goal to improve the aqueous solubility of lamellarins, the lactone ring in their skeleton was replaced with a lactam moiety in azalamellarins. However, the reported synthetic route produced such derivatives in very low yields. Hence, this study focused on developing an efficient simplified total synthetic scheme that could furnish both azalamellarins and the parent lamellarins from the same pyrrole ester intermediates. Subsequent comparative profiling revealed that the introduced lactone‐to‐lactam replacement rendered these molecules less lipophilic, whereas their cancer cytotoxicity remained equipotent to that of the parent compounds. Interestingly, their inhibitory activity was significantly enhanced towards the multifaceted GSK‐3β enzyme. Our results clearly demonstrate the therapeutic potential of this promising class of marine‐derived natural products and justify their further development, especially into anticancer agents.
Kinetic Study on SNAr Reactions of 1‐(Y‐Substituted‐phenoxy)‐2,4‐dinitrobenzenes with Azide Ion: Effect of Changing Nucleophile from Hydroxide to Azide Ion on Reaction Mechanism and Reactivity
Authors: Seo Hyeon‐Ok , Kim Min‐Young , Han So‐Yeop , Um Ik‐Hwan
Published: July 2015

Second‐order rate constants (kN3−) for SNAr reactions of 1‐(Y‐substituted‐phenoxy)‐2,4‐dinitrobenzenes (2a–2h) with in 80 mol % H2O/20 mol % DMSO at 25.0 ± 0.1 °C have been measured spectrophotometrically. The Brønsted‐type plot is linear with βlg = −0.38. The Hammett plots correlated with and constants exhibit highly scattered points. In contrast, the Yukawa–Tsuno plot results in an excellent linear correlation with ρY = 1.02 and r = 0.51, indicating that a negative charge develops partially on the O atom of the leaving Y‐substituted‐phenoxy moiety in the transition state. Accordingly, the reactions have been concluded to proceed through a stepwise mechanism, in which expulsion of the leaving group occurs in the rate‐determining step. Comparison of kN3− with the kOH− values reported previously for the corresponding reactions with OH− has revealed that is only 6‐ to 26‐fold less reactive than OH− toward substrates 2a–2h, although the former is over 11 pKa units less basic than the latter. Solvation and polarizability effects have been suggested to be responsible for the unusual reactivity shown by and OH−. Effects of changing nucleophile from OH− to on reaction mechanism and reactivity are discussed in detail.
Universal Structure Conversion Method for Organic Molecules: From Atomic Connectivity to Three‐Dimensional Geometry
Authors: Kim Yeonjoon , Kim Woo Youn
Published: July 2015

We present a powerful method for the conversion of molecular structures from atomic connectivity to bond orders to three‐dimensional (3D) geometries. There are a number of bond orders and 3D geometries corresponding to a given atomic connectivity. To uniquely determine an energetically more favorable one among them, we use general chemical rules without invoking any empirical parameter, which makes our method valid for any organic molecule. Specifically, we first assign a proper bond order to each atomic pair in the atomic connectivity so as to maximize their sum and the result is converted to a SMILES notation using graph theory. The corresponding 3D geometry is then obtained using force field or ab initio calculations. This method successfully reproduced the bond order matrices and 3D geometries of 10 000 molecules randomly sampled from the PubChem database with high success rates of near 100% except a few exceptional cases. As an application, we demonstrate that it can be used to search for molecular isomers efficiently.
Synthesis and Evaluation of F‐18 Labeled Pyrido[3,2‐B]pyrazine Derivative as a Potential Imaging Agent for Non‐Small‐Cell Lung Cancer
Authors: Park Jeong Hoon , Kim Heejung , Kim Dong‐Yeon , Yang Seung Dae , Hur Min Goo , Kim Sang Wook , Yu Kook Hyun
Published: July 2015

Pyridopyrazine derivatives have been known as Wnt‐2/β‐catenin signaling pathway inhibitors. Wnt‐2 overexpression may be involved in non‐small‐cell lung cancer (NSCLC). A novel 2‐(4‐[
18F]fluorobutoxy)‐3‐(phenylethynyl)pyrido[3,2‐b]pyrazine was prepared to demonstrate the feasibility of NSCLC imaging agent by uptake of Wnt‐2 protein. It was synthesized with tosylated precursor using [
18F]fluoride in radiochemical yield of 44–48%. In cellular uptake evaluation, H460 and H1299, Wnt‐2 expressed cancer cell lines, showed 2.5‐folds higher cellular uptake than that of MCF10A as a control.
Preparation, Characterization, and Microstructure of Poly(ε‐caprolactone–co‐2,2‐dimethyltrimethylene carbonate) Using Metal‐free Organocatalysts
Authors: Wang Yan , Guo Jizhe , Zhang Lifang , Bai Junhua , Niu Jifang , Jiang Lijuan , Li Junfei
Published: July 2015

We investigated the random copolymerization of ε‐caprolactone and 2,2‐dimethyltrimethylene carbonate [poly(CL‐co‐DTC)] promoted by various imidazolium‐based carbenes, including 1‐isopropyl‐3‐p‐methoxyphenylimidazol‐2‐ylidene [Catalyst (1)], 1‐isopropy‐3‐p‐methylphenylimidazol‐2‐ylidene [Catalyst (2)], and 1‐methyl‐3‐p‐methoxyphenyl‐imidazol‐2‐ylidene [Catalyst (3)], all of which are new types of unsymmetrical N‐heterocyclic carbene catalysts. The reaction was carried out in the presence of benzyl alcohol (BnOH) as an initiator in tetrahydrofuran. By varying the experimental conditions and the monomer feed composition, poly(CL‐co‐DTC) with high yield and molecular weight was prepared using the binary system Catalyst (1)/BnOH as catalyst/initiator.
1H NMR and differential scanning calorimetry (DSC) characterizations verified random structures of the polymer. GPC characterization further showed high molecular weights and narrow molecular weight distribution of the final product.
Sampling Polyhexamethylene Guanidine Aerosols Using Eosin Y‐coated Glass Beads
Authors: Choi Sang‐Hyun , Park Seon‐Kyung , Kang Hyun‐Joong , Lee Kyuhong , Kwon Jung‐Hwan
Published: July 2015

Fatalities caused by the use of polyhexamethylene guanidine (PHMG), a general‐purpose chemical germicide used as a humidifier disinfectant in Korea, have raised concerns about exposure to biocide aerosols in indoor environments. A sampler capable of accumulating PHMG from aqueous aerosols was developed as an alternative to low‐volume air samplers. This sampler was prepared by placing glass beads coated with 2‐(2,4,5,7‐tetrabromo‐6‐oxido‐3‐oxo‐3H‐xanthen‐9‐yl)benzoate (Eosin Y) in a custom‐made plastic holder. Passive sampling rates, measured in a bench‐top exposure chamber at two different aqueous PHMG aerosol generation rates, were found to be independent of the experimental conditions. This suggests that the capacity of the sampler to accumulate the PHMG aerosol was sufficient for the sampling duration tested. However, the passive sampling rate was 7.6 × 10−6 m3/h for the sampler area of 22 cm2. This rate is lower than the typical human breathing rate and inadequate for quantitative instrumental analyses at low concentrations in indoor air. A 30‐fold enhancement of the sampling rate was achieved by forced convection using a commercial battery‐operated fan at ≥2000 rpm. With this accelerated sampling rate, the sampler could be used to monitor time‐integrated concentrations of PHMG aerosols in the air.
Effect of Surfactant Concentration on the Size of One‐Pot Synthesized Si Nanoparticles
Authors: Lee Su Jung , Kim Tae Woo , Cho Hyeon Mo , Yoon Sangwoong , Ryou Joonsung , Lee Myong Euy
Published: July 2015

The effect of surfactant concentration on the synthesis of Si nanoparticles (NPs) was studied. Hexyl Si NPs were synthesized using one‐pot synthetic methodology with different ratios of SiCl4:HexylSiCl3 (1:1, 1:2, 1:3, 1:6) to observe the effect of surfactant concentration on the size of Si NPs. In Fourier transform infrared spectroscopy analysis, the Si–H stretching band and the characteristic Si–O–Si bands decreased and eventually disappeared with increasing hexyltrichlorosilane concentration. This suggests that the level of oxidation decreased with excess amounts of hexyltrichlorosilane because the surface area of exposed Si NPs without hexyl capping groups was reduced. Results of transmission electron microscopy and particle size analysis showed that the average diameter of hexyl Si NPs increased slightly from low surfactant concentration (SiCl4:HexylSiCl3 = 1:1) to high concentration (1:6). This might be caused due to the relationship between the surfactant concentration effect and the core material part effect of hexyltrichlorosilane. Agglomerated Si NPs were observed and their luminescence bands were not shifted because the Si NPs were capped by alkyl groups to prevent aggregation.
Biological Evaluation of Secondary Metabolites from the Root of Machilus obovatifolia
Authors: Lin Shan‐Yu , Ko Horng‐Huey , Lee Shiow‐Ju , Chang Hsun‐Shuo , Lin Chu‐Hung , Chen Ih‐Sheng
Published: July 2015

Bioassay‐guided fractionation of the root of Machilus obovatifolia led to the isolation of four new lignans, epihenricine B (1), threo‐(7′R,8′R) and threo‐(7′S,8′S)‐methylmachilusol D (2 and 3), and isofragransol A (4), along with 23 known compounds. The compounds were obtained as isomeric mixtures (i.e., 2/3 and 4/20, resp.). The structures were elucidated by spectral analyses. Among the isolates, 1, licarin A (12), guaiacin (14), (±)‐syringaresinol (21), and (−)‐epicatechin (23) showed ABTS (=2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) cation radical‐scavenging activity, with SC50 values of 11.7±0.5, 12.3±1.1, 11.0±0.1, 10.6±0.3, and 9.5±0.2 μM in 20 min, respectively. In addition, kachirachirol B (17) showed cytotoxicity against the NCI‐H460 cell line with an IC50 value of 3.1 μg/ml.
Wild Sicilian Rosemary: Phytochemical and Morphological Screening and Antioxidant Activity Evaluation of Extracts and Essential Oils
Authors: Napoli Edoardo M. , Siracusa Laura , Saija Antonella , Speciale Antonio , Trombetta Domenico , Tuttolomondo Teresa , La Bella Salvatore , Licata Mario , Virga Giuseppe , Leone Raffaele , Leto Claudio , Rubino Laura , Ruberto Giuseppe
Published: July 2015

To identify the best biotypes, an extensive survey of Sicilian wild rosemary was carried out by collecting 57 samples from various sites, followed by taxonomic characterization from an agronomic perspective. All the biotypes collected were classified as Rosmarinus officinalis L. A cluster analysis based on the morphological characteristics of the plants allowed the division of the biotypes into seven main groups, although the characteristics examined were found to be highly similar and not area‐dependent. Moreover, all samples were analyzed for their phytochemical content, applying an extraction protocol to obtain the nonvolatile components and hydrodistillation to collect the essential oils for the volatile components. The extracts were characterized by LC‐UV‐DAD/ESI‐MS, and the essential oils by GC‐FID and GC/MS analyses. In the nonvolatile fractions, 18 components were identified, namely, 13 flavones, two organic acids, and three diterpenes. In the volatile fractions, a total of 82 components were found, with as predominant components α‐pinene and camphene among the monoterpene hydrocarbons and 1,8‐cineole, camphor, borneol, and verbenone among the oxygenated monoterpenes. Cluster analyses were carried out on both phytochemical profiles, allowing the separation of the rosemary samples into different chemical groups. Finally, the total phenol content and the antioxidant activity of the essential oils and extracts were determined with the Folin–Ciocalteu (FC) colorimetric assay, the UV radiation‐induced peroxidation in liposomal membranes (UV‐IP test), and the scavenging activity of the superoxide radical (O$\rm{{_{2}^{{^\cdot} -}}}$). The present study confirmed that the essential oils and organic extracts of the Sicilian rosemary samples analyzed showed a considerable antioxidant/free radical‐scavenging activity.
New Metabolites from Endolichenic Fungus Pleosporales sp.
Authors: Jiao Yang , Li Gang , Wang Hai‐Ying , Liu Jing , Li Xiao‐Bin , Zhang Lu‐Lu , Zhao Zun‐Tian , Lou Hong‐Xiang
Published: July 2015

Eight new metabolites were obtained from the culture of an endolichenic fungus, Pleosporales sp. Their structures were determined as three terphenyl derivatives, cucurbitarins A–C (1–3, resp.), two structurally related compounds, cucurbitarins D and E (4 and 5, resp.), two benzocoumarins, 3,10‐dihydroxy‐4,8‐dimethoxy‐6‐methylbenzocoumarin (6) and 3,8,10‐trihydroxy‐4‐methoxy‐6‐methylbenzocoumarin (7), as well as one cyclohexenone, (5R)‐5‐hydroxy‐2,3‐dimethylcyclohex‐2‐en‐1‐one (8), based on the spectroscopic data.
Rubrolides as Model for the Development of New Lactones and Their Aza Analogs as Potential Photosynthesis Inhibitors
Authors: Pereira Ulisses A. , Barbosa Luiz C. A. , Demuner Antônio J. , Silva Antônio A. , Bertazzini Michele , Forlani Giuseppe
Published: July 2015

Natural phytotoxins and their synthetic analogs are a potential source of new bioactive compounds for agriculture. Analogs of rubrolides, a class of γ‐alkylidene‐γ‐lactones isolated from different ascidians, have been shown to interfere with the photosynthetic electron‐transport chain, yet their activity needs to be improved. With this aim, ten 5‐aryl‐6‐benzyl‐4‐bromopyridazin‐3(2H)‐ones were prepared in yields ranging from 44 to 88% by reaction of their correspondent γ‐alkylidene‐γ‐lactones with NH2NH2. The structures of these rubrolide analogs were determined by 1H‐ and 13C‐NMR, 2D‐NMR (COSY and HETCOR), NOE difference, and MS techniques. These compounds were evaluated for their abilities of interfering with the light‐driven reduction of ferricyanide by isolated spinach chloroplasts. Lactones with electron‐withdrawing substituents in the para‐position of the benzylidene ring were the most effective inhibitors. Characterization of the activity of 11b/11b′ suggested a mechanism based on the interaction with the plastoquinone binding site of photosystem II. Addition of several compounds to the culture medium of a cyanobacterial model strain was found to inhibit algal growth. However, the relative effectiveness was not consistent with their activity in vitro, suggesting the occurrence of multiple targets and/or detoxyfication mechanisms. Indeed, the compounds showed differential effects on the heterotrophic growth of some crop species, Cucumis sativus and Sorghum bicolor. Pyridazin‐3(2H)‐ones 12e, 12i, and 12j, which have been found poorly active against the photosynthetic electron transport, were the most effective in inhibiting the growth of some weeds, Ipomoea grandifolia and Brachiaria decumbens, under greenhouse conditions.
Methane Catalytic Combustion over Hierarchical Pd@CeO2/Si‐Al2O3: Effect of the Presence of Water
Authors: Monai Matteo , Montini Tiziano , Chen Chen , Fonda Emiliano , Gorte Raymond J. , Fornasiero Paolo
Published: July 2015

The front cover artwork for Issue 14/2015 is provided by the groups of Prof. Raymond J. Gorte and Prof. Dr. Paolo Fornasiero. The image shows the deactivation of hierarchical Pd@CeO2 catalysts for methane combustion in the presence of water. See the Full Paper itself at http://dx.doi.org/10.1002/cctc.201402717.
ChemInform Abstract: Polymorph Engineering of TiO2: Demonstrating How Absolute Reference Potentials Are Determined by Local Coordination.
Authors: Buckeridge John , Butler Keith T. , Catlow C. Richard A. , Logsdail Andrew J. , Scanlon David O. , Shevlin Stephen A. , Woodley Scott M. , Sokol Alexey A. , Walsh Aron
Published: July 2015

A multiscale quantum‐chemical approach is used for examining the electronic structure of eight known TiO2 polymorphs and aligning their ionization potential and electron affinity relative to an absolute energy reference.
ChemInform Abstract: Syntheses and Crystal Structures of New ReO3‐Type‐Derived Transition Metal Oxide Fluorides.
Authors: Nakhal Suliman , Bredow Thomas , Lerch Martin
Published: July 2015

MNb2O3F6 (M: Mg, Zn), MgM2OF8 (M: Ti, Zr), Fe2TiO8F, and TiNb2O5F4 are prepared by stirring the corresponding phase pure mixed‐metal oxides in a 1:1 mixture of 48% aq.
ChemInform Abstract: Molten Salt Synthesis of Sodium Lithium Titanium Oxide Anode Material for Lithium Ion Batteries.
Authors: Yin S. Y. , Feng C. Q. , Wu S. J. , Liu H. L. , Ke B. Q. , Zhang K. L. , Chen D. H.
Published: July 2015

Na2Li2Ti6O14 is prepared by an optimized molten salt synthesis via reaction of Na2CO3, Li2CO3 (5‐20% excess to compensate for Li evaporation), and TiO2 in a eutectic NaCl/KCl flux (Al2O3 crucible, 700—900 °C, 2—16 h).
ChemInform Abstract: Synthesis and Characterization of the LiMnBO3—LiCoBO3 Solid Solution and Its Use as a Lithium‐Ion Cathode Material.
Authors: Le Roux Barbara , Bourbon Carole , Lebedev Oleg I. , Colin Jean‐Francois , Pralong Valerie
Published: July 2015

The complete solid solution series of monoclinic Li(Mn1‐xCox)BO3 (0 ≤ x ≤ 1) is synthesized from mixtures of M3(BO3)2 (M: Mn, Co), Li2CO3, and H3BO3 (Ar atmosphere, 500 °C, 6 h) and characterized by powder XRD, TEM, and electrochemical measurements.
ChemInform Abstract: Bi2WO6 Nanosheets Synthesized by a Hydrothermal Method: Photocatalytic Activity Driven by Visible Light and the Superhydrophobic Property with Water Adhesion.
Authors: Yang Chengyu , Huang Yan , Li Taohai , Li Feng
Published: July 2015

Bi2WO6 nanosheets are prepared at pH 9 and 11 by hydrothermal reaction of Bi(NO3)3 and Na2WO4 (autoclave, 140 °C, 24 h).
ChemInform Abstract: K2Hg2Se3: Large‐Scale Synthesis of a Photoconductor Material Prototype with a Columnar Polyanionic Substructure.
Authors: Thiele Guenther , Lippert Sina , Fahrnbauer Felix , Bron Philipp , Oeckler Oliver , Rahimi‐Iman Arash , Koch Martin , Roling Bernhard , Dehnen Stefanie
Published: July 2015

K2Hg2Se3 is prepared in a 50 g per batch scale by thermal fusion of K2Se and HgSe in 1:2 ratio (O2/methane burner, silica glass ampoule, 10 min) and subsequent solvothermal treatment in ethylenediamine (autoclave, 150 °C, 2 d; 94% yield).
ChemInform Abstract: Hybrid One‐Dimensional 15‐Crown‐5‐ether‐uranyl‐selenate Polymers in [K@(C10H20O5)] [(UO2)(SeO4)(HSeO4)(H2O)]: Synthesis and Characterization.
Authors: Gurzhiy Vladislav V. , Tyumentseva Olga S. , Krivovichev Sergey V. , Tananaev Ivan G.
Published: July 2015

Yellow‐green prismatic crystals of the title compound are obtained from an aqueous solution containing UO2(NO3)2, K2C2O4, H2SeO4, and 15‐crown‐5 by evaporation at room temperature.
ChemInform Abstract: Synthesis and Crystal Structure of the Electron‐Rich Cyano‐Rhodate Ba3[Rh(CN)3].
Authors: Jach Franziska , Hoehn Peter , Prots Yurii , Ruck Michael
Published: July 2015

Microcrystalline Ba3[Rh(CN)3] is prepared from Ba2N, Rh, NaCN and graphite in the molar ratio Ba:Rh:C:N = 3:1:3:2.5 (Nb capsule in silica tube, 1070 K, 24 h).
ChemInform Abstract: Cycloaddition Reactions of Alkyl Cyclopropenecarboxylates Generated in situ with Nitrones: Construction of Substituted Pyrroles and 1,2‐Oxazinanes.
Authors: Hu Junhao , Zhang Min , Gong Yuefa
Published: July 2015

A base promoted [3 + 2] cycloaddition of functional cyclopropanes (I) with nitrones is developed to give bicyclic isoxazolidines as regioisomeric or diastereomeric mixtures.
ChemInform Abstract: Regioselective Annulation of Nitrosopyridine with Alkynes: Straightforward Synthesis of N‐Oxide‐imidazopyridines.
Authors: Manna Srimanta , Narayan Rishikesh , Golz Christopher , Strohmann Carsten , Antonchick Andrey P.
Published: July 2015

N‐Oxide‐imidazopyridines are easily and under reagent‐ and catalyst‐free mild reaction conditions synthesized.
ChemInform Abstract: Bioinspired Organocatalytic Aerobic C—H Oxidation of Amines with an ortho‐Quinone Catalyst.
Authors: Qin Yan , Zhang Long , Lv Jian , Luo Sanzhong , Cheng Jin‐Pei
Published: July 2015

The aerobic oxidative dehydrogenation of α‐branched primary amines and cyclic secondary amines to imines without any metal cocatalyst is presented
ChemInform Abstract: Selective Oxidation of Benzylic, Allylic and Propargylic Alcohols Using Dirhodium(II) Tetraamidinate as Catalyst and Aqueous tert‐Butyl Hydroperoxide as Oxidant.
Authors: Wusiman Abudureheman , Lu Chong‐Dao
Published: July 2015

The dirhodium(II) complex Rh2(Msip)4 efficiently catalyzes the oxidation of activated secondary alcohols.
ChemInform Abstract: Direct Fluorination of Styrenes.
Authors: Shao Qian , Huang Yong
Published: July 2015

A wide range of styrenyl and chromenyl fluorides are synthesized by highly selective Ru‐catalyzed olefin monofluorination.
ChemInform Abstract: Iron‐Mediated Markovnikov‐Selective Hydro‐Trifluoromethylthiolation of Unactivated Alkenes.
Authors: Yang Tao , Lu Long , Shen Qilong
Published: July 2015

A wide range of secondary alkyl trifluoromethyl thioethers are obtained under mild reaction conditions.
ChemInform Abstract: [RhCp*Cl2]2‐Catalyzed Directed N‐Boc Amidation of Arenes “on Water”.
Authors: Ali Md Ashif , Yao Xiayin , Sun Hao , Lu Hongjian
Published: July 2015

Easily prepared tert‐butyl 2,4‐dinitrophenoxycarbamate (II) is used as new and stable nitrene source for the efficient “on water” C—H amidation of arenes affording the desired N‐Boc‐aminated products with good functional group tolerance.
ChemInform Abstract: Palladium Supported on Poly (Ionic Liquid) Entrapped Magnetic Nanoparticles as a Highly Efficient and Reusable Catalyst for the Solvent‐Free Heck Reaction.
Authors: Liu Wendong , Wang Dongfang , Duan Yajing , Zhang Yahui , Bian Fengling
Published: July 2015

The title catalyst shows excellent activity for the coupling of aryl iodides and bromides with various olefins.
ChemInform Abstract: Significant Enhancement in the Efficiency and Selectivity of Iron‐Catalyzed Oxidative Cross‐Coupling of Phenols by Fluoroalcohols.
Authors: Gaster Eden , Vainer Yulia , Regev Almog , Narute Sachin , Sudheendran Kavitha , Werbeloff Aviya , Shalit Hadas , Pappo Doron
Published: July 2015

Phenols and naphthols are regioselectively coupled with 2‐oxocyclopentanoic acid ester (II), arenes (IV) and (VII), polyaromatic hydrocarbons, e.
ChemInform Abstract: Heterogeneous Platinum‐Catalyzed C—H Perfluoroalkylation of Arenes and Heteroarenes.
Authors: He Lin , Natte Kishore , Rabeah Jabor , Taeschler Christoph , Neumann Helfried , Brueckner Angelika , Beller Matthias
Published: July 2015

An operationally simple protocol for the direct perfluoroalkylation of a broad scope of aryl and heteroaryl compounds with perfluoroalkyl iodide or bromide is presented.
ChemInform Abstract: Modular C—H Functionalization Cascade of Aryl Iodides.
Authors: Shi Hang , Babinski David J. , Ritter Tobias
Published: July 2015

A novel and general method for the construction of a variety of disubstituted anilines is reported.
ChemInform Abstract: Phosphine‐Catalyzed Remote β‐C—H Functionalization of Amines Triggered by Trifluoromethylation of Alkenes: One‐Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles.
Authors: Yu Peng , Zheng Sheng‐Cai , Yang Ning‐Yuan , Tan Bin , Liu Xin‐Yuan
Published: July 2015

This phosphine‐catalyzed tandem radical process enables the selective and concomitant functionalization of an unactivated alkene and the remote β‐C—H bond of amine derivatives, providing a facile access to bistrifluoromethylated enamides with good regio‐, chemo‐, and stereoselectivity under metal‐free conditions.
ChemInform Abstract: Direct Trifluoromethylthiolation of Unactivated C(sp3)—H Using Silver(I) Trifluoromethanethiolate and Potassium Persulfate.
Authors: Wu Hao , Xiao Zhiwei , Wu Junhui , Guo Yong , Xiao Ji‐Chang , Liu Chao , Chen Qing‐Yun
Published: July 2015

The trifluoromethylthiolation of unactivated C—H bonds is proposed to involve a radical process in which potassium persulfate shows key behavior in both the activation of the C—H bond and the oxidation of the silver reagent.
ChemInform Abstract: Copper‐Catalyzed trans‐Carbohalogenation of Terminal Alkynes with Functionalized Tertiary Alkyl Halides.
Authors: Che Chao , Zheng Hanliang , Zhu Gangguo
Published: July 2015

The presented protocol furnishes alkenyl halides with excellent regioselectivities and trans‐stereoselectivities.
ChemInform Abstract: Palladium on Manganese Ferrite: An Efficient Catalyst for Ligand Free Decarboxylative Sonogashira Reaction with Arene Diazonium Tetrafluoroborate.
Authors: Jadhav Vilas G. , Sarode Sachin A. , Nagarkar Jayashree M.
Published: July 2015

Decarboxylative cross‐coupling of arenediazonium tetrafluoroborates with phenylpropynoic acid using a magnetically recyclable catalyst gives arylphenylacetylenes.
ChemInform Abstract: Rational Ligand Design for the Arylation of Hindered Primary Amines Guided by Reaction Progress Kinetic Analysis.
Authors: Ruiz‐Castillo Paula , Blackmond Donna G. , Buchwald Stephen L.
Published: July 2015

A generally applicable method for the cross‐coupling of sterically hindered primary amines with a range of aryl or hetaryl chlorides or bromides, respectively, equipped with various functional groups is developed.
ChemInform Abstract: Silver‐Catalyzed Double‐Decarboxylative Cross‐Coupling of α‐Keto Acids with Cinnamic Acids in Water: A Strategy for the Preparation of Chalcones.
Authors: Zhang Ning , Yang Daoshan , Wei Wei , Yuan Li , Nie Fafa , Tian Laijin , Wang Hua
Published: July 2015

The coupling fails when either aliphatic α‐keto acids or crotonic acid are used.
ChemInform Abstract: Access to Nitriles from Aldehydes Mediated by an Oxoammonium Salt.
Authors: Kelly Christopher B. , Lambert Kyle M. , Mercadante Michael A. , Ovian John M. , Bailey William F. , Leadbeater Nicholas E.
Published: July 2015

The spent oxidant can be recovered and regenerated.
ChemInform Abstract: A New Modification of the Passerini Reaction: A One‐Pot Synthesis of α‐Acyloxyamides via Sequential Kornblum Oxidation/Passerini Reaction.
Authors: Adib Mehdi , Sheikhi Ehsan , Azimzadeh Marjan
Published: July 2015

The high‐yielding four component reaction is based on the in situ reaction of benzyl chlorides, bromides, or tosylates with dimethyl sulfoxide to the corresponding aldehydes which are further converted using alkyl or benzyl isocyanides and aryl or alkyl carboxylic acids to α‐acyloxyamides.
ChemInform Abstract: Direct Difunctionalization of Alkenes with Sulfinic Acids and NBS Leading to β‐Bromo Sulfones.
Authors: Wei Wei , Liu Xiaoxia , Yang Daoshan , Dong Ruimei , Cui Ying , Yuan Fei , Wang Hua
Published: July 2015

When α‐methyl styrenes are used as substrates the corresponding allylic sulfones (VII) are obtained instead of the expected β‐bromo sulfones.
ChemInform Abstract: O2‐Mediated C(sp2)—X Bond Oxygenation: Autoxidative Carbon—Heteroatom Bond Formation Using Activated Alkenes as a Linkage.
Authors: Lu Qingquan , Chen Jiyong , Liu Chao , Huang Zhiyuan , Peng Pan , Wang Huamin , Lei Aiwen
Published: July 2015

Various β‐keto compounds such as (III) and (V) are obtained via an O2‐mediated C(sp2)—X bond oxygenation process without any external organic oxidant or metal catalyst.
ChemInform Abstract: Indium(III)‐Catalyzed Reductive Monoalkylation of Electron‐Rich Benzenes with Aliphatic Carboxylic Acids Leading to Arylalkane Derivatives.
Authors: Moriya Toshimitsu , Takayama Kentaro , Konakahara Takeo , Ogiwara Yohei , Sakai Norio
Published: July 2015

A one‐pot monoalkylation of benzene derivatives with aliphatic carboxylic acids having a variety of substituents with a combination of InI3, hydrosilane, and molecular iodine is reported.
ChemInform Abstract: Palladium‐Catalyzed Annulation of 9‐Halophenanthrenes with Alkynes: Synthesis, Structural Analysis, and Properties of Acephenanthrylene‐Based Derivatives.
Authors: Liu En‐Chih , Chen Min‐Kuan , Li Jen‐Yi , Wu Yao‐Ting
Published: July 2015

The photophysical and electrochemical properties of the annulated products are investigated.
ChemInform Abstract: A Green, Facile Approach for the Multicomponent Synthesis of Bioactive Spiro[indoline‐3,7′‐pyrrolo[1,2‐c]imidazole] Derivatives.
Authors: Shen Tianhua , Zhou Yongbing , Che Fengfeng , Yu Jiangxia , Lin Yan , Song Qingbao
Published: July 2015

A variety of the title spiro‐compounds (IV) (17 examples) are synthesized via a NaHCO3‐catalyzed three‐component reaction.
ChemInform Abstract: Carboxylic Acids as Traceless Directing Groups for the Rhodium(III)‐Catalyzed Decarboxylative C—H Arylation of Thiophenes.
Authors: Zhang Yuanfei , Zhao Huaiqing , Zhang Min , Su Weiping
Published: July 2015

The method is first applied to the coupling of various functionalized thiophenes with acid (II).
ChemInform Abstract: A CuII‐N,P Oxazolinylferrocene Ligand Complex for the Asymmetric [3 + 2] 1,3‐Dipolar Cycloaddition of Azomethine Ylide with Malonates.
Authors: Dai Li , Xu Di , Tang Li‐Wei , Zhou Zhi‐Ming
Published: July 2015

The reaction tolerates substrates endowed with aromatic, hetaromatic, and aliphatic substituents.
ChemInform Abstract: Direct Synthesis of N‐H Carbazoles via Iridium(III)‐Catalyzed Intramolecular C—H Amination.
Authors: Suzuki Chiharu , Hirano Koji , Satoh Tetsuya , Miura Masahiro
Published: July 2015

The dehydrogenative cyclization of 2‐aminobiphenyls in presence of a copper co‐catalyst under aerobic conditions is described.
ChemInform Abstract: Green Protection of Pyrazole, Thermal Isomerization and Deprotection of Tetrahydropyranylpyrazoles, and High‐Yield, One‐Pot Synthesis of 3(5)‐Alkylpyrazoles.
Authors: Ahmed Basil M. , Mezei Gellert
Published: July 2015

A new approach for the solvent‐ and catalyst‐free protection of pyrazole followed by its selective alkylation is given.
ChemInform Abstract: Ring Expansion of Aziridine‐2‐carboxylates. An Efficient Entry to Imidazolidin‐2‐ones and Oxazolidin‐2‐imines.
Authors: Tabarki Mohamed Ali , Besbes Rafaa
Published: July 2015

The ring‐expansion of aziridines (I) with isocyanates proceeds with high regio‐ and stereoselectivity.
ChemInform Abstract: Synthesis of Oxazolidine‐2,4‐diones by a Tandem Phosphorus‐Mediated Carboxylative Condensation—Cyclization Reaction Using Atmospheric Carbon Dioxide.
Authors: Zhang Wen‐Zhen , Xia Tian , Yang Xu‐Tong , Lu Xiao‐Bing
Published: July 2015

Oxazolidine‐2,4‐diones [(IV), (VIII), and (X)] are conveniently synthesized via title tandem reaction in one‐pot fashion using carbon dioxide under atmospheric pressure and transition‐metal free conditions.
ChemInform Abstract: Ti(IV)‐Catalyzed Cascade Synthesis of Tetrahydrofuro[3,2‐d]oxazole from Arene‐1,4‐diones.
Authors: Li Gang , Li Li , Huang Haihong , Yin Dali
Published: July 2015

The operationally simple and efficient procedure has a broad substrate scope and proceeds diastereoselectively.
ChemInform Abstract: Efficient Synthesis of a New Class of Sulfonamide‐Substituted Coumarins.
Authors: Farahi Mahnaz , Karami Bahador , Tanuraghaj Hamideh Mohamadi
Published: July 2015

The NaOH‐catalyzed reaction of coumarin (I) with N‐sulfonyl aldimines provides the title compounds (III) in good to excellent yields.
ChemInform Abstract: Meglumine Catalyzed One‐Pot, Three‐Component Combinatorial Synthesis of Pyrazoles Bearing a Coumarin Unit.
Authors: Li Xiao‐Tang , Liu Yu‐Heng , Liu Xin , Zhang Zhan‐Hui
Published: July 2015

A new simple, efficient, and eco‐friendly procedure for the synthesis of the title compounds is developed using a one‐pot three‐component reaction of salicylaldehyde, pyran‐2‐one, and hydrazine.
ChemInform Abstract: Benzoyl Peroxide Promoted Radical ortho‐Alkylation of Nitrogen Heteroaromatics with Simple Alkanes and Alcohols.
Authors: Fang Lei , Chen Liangshun , Yu Jianjun , Wang Limin
Published: July 2015

A catalytic amount of benzoyl peroxide initiates a crossdehydrogenative coupling reaction of N‐iminopyridine ylides with alkanes and alcohols in a metal‐free, open‐air system, leading to 2‐alkylpyridines with high regioselectivity in moderate to good yields without an additional reduction step to remove the activated group.
ChemInform Abstract: Friedlander Synthesis of Quinolines Promoted by Polymer‐Bound Sulfonic Acid.
Authors: Maleki Behrooz , Seresht Esmail Rezaei , Ebrahimi Zahra
Published: July 2015

A novel, facile and green method for the convenient preparation of a variety of quinoline derivatives is developed.
ChemInform Abstract: Synthesis of Novel 2‐Oxoquinoline Derivatives via Ugi‐Four‐Component‐Heck Reaction.
Authors: Rasouli Mohammad Ali , Mahdavi Mohammad , Saeedi Mina , Ranjbar Parviz Rashidi , Shafiee Abbas , Foroumadi Alireza
Published: July 2015

Ugi coupling of 2‐bromoanilines with aromatic aldehydes, vinylacetic acid, and isocyanides followed by intramolecular Heck reaction of the Ugi adducts (V) provides the title compounds (VI) (11 examples) in good yield.
ChemInform Abstract: Double Heteroannulation Reactions of 1‐Naphthol with Alkyl‐ and Arylmethylidene Derivatives of Malononitrile Dimer.
Authors: Bardasov Ivan N. , Alekseeva Anastasiya U. , Mihailov Denis L. , Ershov Oleg V. , Grishanov Dmitry A.
Published: July 2015

The synthesis of novel chromeno pyridine derivatives (IV) is achieved through double heteroannulation reactions of Michael adducts derived from 1‐naphthol and derivatives of malononitrile dimer.