bluuebunny/crossref_metadata_2025 huggingface dataset:
Single neurons on microelectrode array chip: manipulation and analyses
Authors: Zhang Hongyong , Wang Pengbo , Huang Nan , Zhao Lingrui , Su Yi , Li Lingfei , Bian Sumin , Sawan Mohamad
Published: September 2023

Chips-based platforms intended for single-cell manipulation are considered powerful tools to analyze intercellular interactions and cellular functions. Although the conventional cell co-culture models could investigate cell communication to some extent, the role of a single cell requires further analysis. In this study, a precise intercellular interaction model was built using a microelectrode array [microelectrode array (MEA)]-based and dielectrophoresis-driven single-cell manipulation chip. The integrated platform enabled precise manipulation of single cells, which were either trapped on or transferred between electrodes. Each electrode was controlled independently to record the corresponding cellular electrophysiology. Multiple parameters were explored to investigate their effects on cell manipulation including the diameter and depth of microwells, the geometry of cells, and the voltage amplitude of the control signal. Under the optimized microenvironment, the chip was further evaluated using 293T and neural cells to investigate the influence of electric field on cells. An examination of the inappropriate use of electric fields on cells revealed the occurrence of oncosis. In the end of the study, electrophysiology of single neurons and network of neurons, both differentiated from human induced pluripotent stem cells (iPSC), was recorded and compared to demonstrate the functionality of the chip. The obtained preliminary results extended the nature growing model to the controllable level, satisfying the expectation of introducing more elaborated intercellular interaction models.
Case report: Pheochromocytoma complicated by type B aortic dissection
Authors: Yi Dan , Liu Xiatian , Fan Libin
Published: September 2023

Introduction

Pheochromocytomas combined with aortic dissections are rare. Treatment of aortic dissection can be complicated by the presence of pheochromocytomas.

Case presentation

we present the case of a 48-year-old male who visited the hospital with chest and back pain for 13 h. Enhanced computed tomography (CT) revealed a type B aortic dissection combined with a left adrenal mass (72 mm). Elevated 24-h urinary vanillylmandelic acid levels can aid in the diagnosis of pheochromocytomas. Aortic dissection due to unstable hypertension secondary to pheochromocytoma is rare and complicates the procedure. Thoracic endovascular aortic repair was performed, and antihypertensive treatments were administered after surgery. After hypertension was addressed and the patient was stable, laparoscopic resection of the adrenal mass was performed.

Conclusions

despite its rarity, it is important to consider pheochromocytoma as a differential factor for unstable hypertension when an aortic dissection is found.
Association between resolved hepatitis B virus infection and femoral and spinal bone mineral density in American adults: a cross-sectional study
Authors: Yang Yan , Zeng Jing , Zhang Tingting , Wang Jinjing , Fan Xiaojing , Wang Qiaomin , Wang Xuan , Qi Zhengrong , Fang Yi
Published: September 2023

Background

Hepatitis B virus (HBV) infection is a global health concern that can potentially affect bone health. However, the specific association between resolved HBV infection and bone mineral density (BMD) remains unclear. This cross-sectional study aimed to investigate the potential association between resolved HBV infection and femoral and spinal BMD in adults in the United States.

Methods

This cross-sectional study included participants aged 20-79 years with negative HBV surface antigen (HBsAg) from the 2005-2010, 2013-2014, and 2017-2018 cycles of the National Health and Nutrition Examination Survey. Resolved HBV infection was defined as negative HBsAg with positive HBV core antibody. BMD was measured using dual-energy X-ray absorptiometry. Propensity score matching (PSM) was performed to balance baseline characteristics.

Results

A total of 10,333 eligible participants were identified and matched, of whom 737 (7.1%) had resolved HBV infection. Men with resolved HBV infection had significantly lower femoral and spinal BMD compared to those with no HBV infection, both before and after PSM. In the matched population, resolved HBV infection in men was negatively associated with femoral BMD (β= -0.024, 95% CI: -0.047 to -0.002, p = 0.0332) and spinal BMD (β= -0.025, 95% CI: -0.048 to -0.002, p = 0.0339). Postmenopausal women exhibited similar trends to men, while premenopausal women showed a tendency towards higher BMD, although statistical significance was not consistently achieved. Subgroup and sensitivity analyses supported the robustness of the findings.

Conclusion

The study suggests a negative association between resolved HBV infection and femoral and spinal BMD in adult men in the United States. It highlights the importance of routine bone density assessments and the consideration of anti-osteoporotic therapy, if necessary, in individuals with resolved HBV infection.
Research on the decision framework of an energy storage traction system plan for rail transit from the low-carbon perspective—based on the interval-value Pythagorean intuitionistic fuzzy environment
Authors: Lin Lijun , Xu Wenjie , Liu Bo , Wang Wenxuan , Zhao Yulin , Tao Min
Published: September 2023

Low carbonization of the traction system is the key to low-carbon rail transit operation, and its preliminary plan decision plays a decisive role in whether low carbon can be achieved in later stages. Therefore, how to achieve scientific decisions of energy storage traction systems in a low-carbon background is a problem that needs to be solved. The innovation of this paper is as follows: first, aiming at the reality of the rail transit energy storage traction system, a decision index system of the energy storage traction system which contains seven attributes and 18 criteria is constructed; second, aiming at the uncertainty of decision information and the decision makers’ aversion to risk, the decision model adapted to the energy storage traction system decision is constructed based on the interval Pythagorean intuitionistic fuzzy number and VIKOR model principle. The decision index system and decision model together constitute the decision framework. The case study results show that the decision index system can provide scientific guidance for the decision of the energy storage traction system, and the decision model can provide risk aversion type decision results with good robustness.
An extraordinary chlorophyll-a enhancement event jointly induced by two sequential tropical cyclones in the Kuroshio region south of Japan
Authors: Zheng Hui , Zhang Wen-Zhou
Published: September 2023

We used Biogeochemical-Argo (BGC-Argo) float observation profiles and satellite data to investigate the physical-biogeochemical processes of a phytoplankton biomass rise in the Kuroshio region south of Japan during a period of two sequential tropical cyclones (TCs)—Hagibis and Neoguri—in October 2019. During TC Hagibis, prominent sea surface cooling and surface chlorophyll-a (Chl-a) increase occurred within a pre-existing cyclonic eddy (CE) south of Japan. Because of TC-induced mixing and upwelling, the maximum cooling happened at the depth of 57 m where water temperature dropped by 6°C. The dramatic mixing and upwelling redistributed chlorophyll-a vertically (reducing subsurface Chl-a and increasing surface Chl-a) with little augment of depth-integrated Chl-a in the upper ocean above 160 m depth. Meanwhile, the mixing and upwelling transported nutrients from the subsurface to the surface layer. In the week after Hagibis, the depth-integrated Chl-a greatly increased. Subsequently, TC Neoguri obviously enhanced the augment of phytoplankton biomass although it was weaker than Hagibis. The upwelling induced by Hagibis increased nutrients in the water below 80 m, providing a very favorable condition for the subsequent TC Neoguri to further promote the growth of phytoplankton. The intense precipitation accompanying with Neoguri brought the coastal water with rich terrestrial material to offshore ocean, increasing nutrients and decreasing salinity in the subsurface layer. These both contributed to the marked increase in Chl-a during Neoguri. Our results demonstrated that the two sequential TCs worked together with a cyclonic eddy to cause a drastic and complex Chl-a enhancement event in the Kuroshio region south of Japan.
Identification and functional analysis of novel protein-encoding sequences related to stress-resistance
Authors: Huanca-Juarez Joshelin , Nascimento-Silva Edson Alexandre , Silva Ninna Hirata , Silva-Rocha Rafael , Guazzaroni María-Eugenia
Published: September 2023

Currently, industrial bioproducts are less competitive than chemically produced goods due to the shortcomings of conventional microbial hosts. Thus, is essential developing robust bacteria for improved cell tolerance to process-specific parameters. In this context, metagenomic approaches from extreme environments can provide useful biological parts to improve bacterial robustness. Here, in order to build genetic constructs that increase bacterial resistance to diverse stress conditions, we recovered novel protein-encoding sequences related to stress-resistance from metagenomic databases using an in silico approach based on Hidden-Markov-Model profiles. For this purpose, we used metagenomic shotgun sequencing data from microbial communities of extreme environments to identify genes encoding chaperones and other proteins that confer resistance to stress conditions. We identified and characterized 10 novel protein-encoding sequences related to the DNA-binding protein HU, the ATP-dependent protease ClpP, and the chaperone protein DnaJ. By expressing these genes in Escherichia coli under several stress conditions (including high temperature, acidity, oxidative and osmotic stress, and UV radiation), we identified five genes conferring resistance to at least two stress conditions when expressed in E. coli. Moreover, one of the identified HU coding-genes which was retrieved from an acidic soil metagenome increased E. coli tolerance to four different stress conditions, implying its suitability for the construction of a synthetic circuit directed to expand broad bacterial resistance.
Assessment of neutralization susceptibility of Omicron subvariants XBB.1.5 and BQ.1.1 against broad-spectrum neutralizing antibodies through epitopes mapping
Authors: Shah Masaud , Woo Hyun Goo
Published: September 2023

The emergence of new variants of the SARS-CoV-2 virus has posed a significant challenge in developing broadly neutralizing antibodies (nAbs) with guaranteed therapeutic potential. Some nAbs, such as Sotrovimab, have exhibited varying levels of efficacy against different variants, while others, such as Bebtelovimab and Bamlanivimab-etesevimab are ineffective against specific variants, including BQ.1.1 and XBB. This highlights the urgent need for developing broadly active monoclonal antibodies (mAbs) providing prophylactic and therapeutic benefits to high-risk patients, especially in the face of the risk of reinfection from new variants. Here, we aimed to investigate the feasibility of redirecting existing mAbs against new variants of SARS-CoV-2, as well as to understand how BQ.1.1 and XBB.1.5 can evade broadly neutralizing mAbs. By mapping epitopes and escape sites, we discovered that the new variants evade multiple mAbs, including FDA-approved Bebtelovimab, which showed resilience against other Omicron variants. Our approach, which included simulations, endpoint free energy calculation, and shape complementarity analysis, revealed the possibility of identifying mAbs that are effective against both BQ.1.1 and XBB.1.5. We identified two broad-spectrum mAbs, R200-1F9 and R207-2F11, as potential candidates with increased binding affinity to XBB.1.5 and BQ.1.1 compared to the reference (Wu01) strain. Additionally, we propose that these mAbs do not interfere with Angiotensin Converting Enzyme 2 (ACE2) and bind to conserved epitopes on the receptor binding domain of Spike that are not-overlapping, potentially providing a solution to neutralize these new variants either independently or as part of a combination (cocktail) treatment.
Case report: Perilymphatic fistula from a round window microfissure
Authors: Seo Toru , Kemmochi Arata , Koike Yosuke , Aomi Mizuho , Shinohe Tatsuya , Komori Manabu
Published: September 2023

A microfissure near the round window niche is an anatomical structure that communicates between middle ear and the ampulla of the posterior semicircular canal. It has been suggested that the microfissure can cause inner ear symptoms; however, the etiology has not yet been confirmed clinically. We report, to our knowledge, the first case of microfissure with complaint of hearing loss and vertigo and improvement in hearing after surgical sealing of the microfissure. A 50-year-old man complained of hearing disturbance, tinnitus with flowing-water sound in the left ear, and a floating sensation upon pushing the left tragus. He had moderate sensorineural hearing loss (43.3 dB) in the left ear for 3 days. His hearing worsened and he complained of severe vertigo. An exploratory tympanotomy was performed 8 days after onset. A microfissure and accumulation of clear fluid in the floor of the round window niche were detected, and leakage point was packed with connective tissue. One month after surgery, his hearing (20.0 dB) and disequilibrium had improved. The inner ear symptoms improved after the surgery in this case, suggesting that the microfissure might have caused the symptoms.
Weak synchronization can alter circadian period length: implications for aging and disease conditions
Authors: Myung Jihwan , Hong Sungho , Schmal Christoph , Vitet Hélène , Wu Mei-Yi
Published: September 2023

The synchronization of multiple oscillators serves as the central mechanism for maintaining stable circadian rhythms in physiology and behavior. Aging and disease can disrupt synchronization, leading to changes in the periodicity of circadian activities. While our understanding of the circadian clock under synchronization has advanced significantly, less is known about its behavior outside synchronization, which can also fall within a predictable domain. These states not only impact the stability of the rhythms but also modulate the period length. In C57BL/6 mice, aging, diseases, and removal of peripheral circadian oscillators often result in lengthened behavioral circadian periods. Here, we show that these changes can be explained by a surprisingly simple mathematical relationship: the frequency is the reciprocal of the period, and its distribution becomes skewed when the period distribution is symmetric. The synchronized frequency of a population in the skewed distribution and the macroscopic frequency of combined oscillators differ, accounting for some of the atypical circadian period outputs observed in networks without synchronization. Building on this finding, we investigate the dynamics of circadian outputs in the context of aging and disease, where synchronization is weakened.
Chronic subdural electrocorticography in nonhuman primates by an implantable wireless device for brain-machine interfaces
Authors: Yan Tianfang , Suzuki Katsuyoshi , Kameda Seiji , Maeda Masashi , Mihara Takuma , Hirata Masayuki
Published: September 2023

Background

Subdural electrocorticography (ECoG) signals have been proposed as a stable, good-quality source for brain-machine interfaces (BMIs), with a higher spatial and temporal resolution than electroencephalography (EEG). However, long-term implantation may lead to chronic inflammatory reactions and connective tissue encapsulation, resulting in a decline in signal recording quality. However, no study has reported the effects of the surrounding tissue on signal recording and device functionality thus far.

Methods

In this study, we implanted a wireless recording device with a customized 32-electrode-ECoG array subdurally in two nonhuman primates for 15 months. We evaluated the neural activities recorded from and wirelessly transmitted to the devices and the chronic tissue reactions around the electrodes. In addition, we measured the gain factor of the newly formed ventral fibrous tissue in vivo.

Results

Time-frequency analyses of the acute and chronic phases showed similar signal features. The average root mean square voltage and power spectral density showed relatively stable signal quality after chronic implantation. Histological examination revealed thickening of the reactive tissue around the electrode array; however, no evident inflammation in the cortex. From gain factor analysis, we found that tissue proliferation under electrodes reduced the amplitude power of signals.

Conclusion

This study suggests that subdural ECoG may provide chronic signal recordings for future clinical applications and neuroscience research. This study also highlights the need to reduce proliferation of reactive tissue ventral to the electrodes to enhance long-term stability.
Modification of the synaptic cleft under excitatory conditions
Authors: Tao-Cheng Jung-Hwa , Moreira Sandra L. , Winters Christine A. , Reese Thomas S. , Dosemeci Ayse
Published: September 2023

The synaptic cleft is the extracellular part of the synapse, bridging the pre- and postsynaptic membranes. The geometry and molecular organization of the cleft is gaining increased attention as an important determinant of synaptic efficacy. The present study by electron microscopy focuses on short-term morphological changes at the synaptic cleft under excitatory conditions. Depolarization of cultured hippocampal neurons with high K+ results in an increased frequency of synaptic profiles with clefts widened at the periphery (open clefts), typically exhibiting patches of membranes lined by postsynaptic density, but lacking associated presynaptic membranes (18.0% open clefts in high K+ compared to 1.8% in controls). Similarly, higher frequencies of open clefts were observed in adult brain upon a delay of perfusion fixation to promote excitatory/ischemic conditions. Inhibition of basal activity in cultured neurons through the application of TTX results in the disappearance of open clefts whereas application of NMDA increases their frequency (19.0% in NMDA vs. 5.3% in control and 2.6% in APV). Depletion of extracellular Ca2+ with EGTA also promotes an increase in the frequency of open clefts (16.6% in EGTA vs. 4.0% in controls), comparable to that by depolarization or NMDA, implicating dissociation of Ca2+-dependent trans-synaptic bridges. Dissociation of transsynaptic bridges under excitatory conditions may allow perisynaptic mobile elements, such as AMPA receptors to enter the cleft. In addition, peripheral opening of the cleft would facilitate neurotransmitter clearance and thus may have a homeostatic and/or protective function.
Red and processed meat and pancreatic cancer risk: a meta-analysis
Authors: Sun Yudi , He Xinyi , Sun Yan
Published: September 2023

Background

The relationship between red and processed meat consumption and pancreatic cancer risk is controversial and no study has looked specifically at the correlation for 6 years. We conducted a meta-analysis to summarize the evidence about the association between them.

Methods

We systematically searched PubMed, Embase and Cochrane Library for studies of red or processed meat consumption and pancreatic cancer published from December 2016 to July 2022. We performed random-effects models to pool the relative risks from individual studies. Subgroup analyses were used to figure out heterogeneity. We also performed publication bias analysis.

Results

Seven cohort studies and one case–control study that contained a total of 7,158 pancreatic cancer cases from 805,177 participants were eligible for inclusion. The combined RRs (95% CI) comparing highest and lowest categories were 1.07 (95% CI: 0.91–1.26; p = 0.064) for red meat and 1.04 (95% CI: 0.81–1.33; p = 0.006) for processed meat with statistically significant heterogeneity.

Conclusion

This meta-analysis suggested that red and processed meat consumption has no relationship with pancreatic cancer risk.
Four-week administration of an energy and protein dense oral nutritional supplement improves micronutrient concentrations but does not completely correct deficiencies in institutionalized malnourished older adults
Authors: Sanchez Manuel , Courtois-Amiot Pauline , Capdepon Audrey , Neveux Nathalie , Gautry Julien , Dorigny Béatrice , Brossault Ludovic , Bouillanne Olivier , Aussel Christian , Raynaud-Simon Agathe , Cynober Luc
Published: September 2023

Introduction

Poor food intake is common among elderly living in nursing homes, leading to micronutrient deficiency (MD). There are no recommendations for the management of MD in malnourished older adults.

Methods

We conducted a single arm, open-label, multicenter interventional study in institutionalized malnourished older adults to describe the effect of a 4-week daily energy and protein dense oral nutritional supplementation (ONS, 600 kcal, 30 g protein per unit) containing 50% of the recommended daily micronutrient intake on micronutrient status. Plasma concentrations of vitamins (A, B9, B12, C, E), magnesium (Mg), selenium (Se) and zinc (Zn), and erythrocyte vitamin B9 were measured at baseline and after 4 weeks.

Results

Forty-six participants completed the study (age 87.4 ± 6.6). At baseline, the most frequent MD were Se (48%), Zn (35%), Mg (24%) and vitamin C (24%). Plasma concentrations of vitamins B9, B12, C and E, Mg, Se and Zn significantly increased and the proportion of subjects with at least one MD decreased (p = 0.006). However, after 4 weeks, 40% of subjects still had at least one MD.

Discussion

ONS consumption improved micronutrient status but did not correct MD in all participants. Our data suggest that the prescription of vitamin, mineral and trace element supplementation should be considered in institutionalized malnourished older adults in addition to high energy and high protein ONS.
Elucidating Spirocerca lupi spread in the Americas by using phylogenetic and phylogeographic analyses
Authors: Alfaro-Segura Paula , Robleto-Quesada Joby , Montenegro-Hidalgo Víctor M. , Molina-Mora Jose Arturo , Baneth Gad , Verocai Guilherme G. , Rodriguez-Vivas Roger I. , Rojas Alicia
Published: September 2023

Spirocerca lupi is a parasitic nematode of domestic and wild canids of the world. This nematode induces esophageal spirocercosis and may eventually lead to carcinomas, aortic aneurisms, and death of the animal. Two genotypes of S. lupi have been described based on specimens from Europe, Asia, Africa, and Oceania, but no profound analysis has been conducted with S. lupi from the Americas. To study this, S. lupi specimens isolated from domestic dogs from Mexico, Costa Rica, and the United States, were molecularly characterized using 18S rDNA and cox1 fragments. Bayesian inference (BI) phylogenetic trees, Templeton-Crandall-Sing (TCS) haplotype networks and Principal coordinate analysis on nucleotide distances were constructed for each locus separately. In addition, a phylogeographic study using a fragment of the cox1 gene was used to infer the evolutionary history of the genus. BI cox1 trees grouped S. lupi from the Americas in genotype 1, together with Israeli specimens, and showed a high nucleotide identity with those worms. In the TCS network, American specimens clustered next to Israeli S. lupi. Furthermore, the 18S rDNA gene fragment separated Costa Rican worms from African, Asian, and European specimens and other species of the family Spiruridae. Interestingly, the phylogeographic analysis suggested that the origin of S. vulpis was in Europe, and it later diverged into S. lupi that spread first to Africa, then to Asia and finally to the Americas. Therefore, we suggest that the worms from the American continent might have originated from Asia by dispersion of infected intermediate, paratenic or definitive hosts.
Endovascular treatment of a mycotic aneurysm in an immunocompromised child with acute leukemia—case report and review of the literature
Authors: Diepenbruck Sabine Daphne , Jakob Andre , Haas Nikolaus Alexander , Mandilaras Guido
Published: September 2023

Mycotic aneurysms are dilatations of an artery, a rare but severe complication arising from infectious obliteration of the vessel wall. Thoracic aneurysms often present with unspecific symptoms and multiple diagnostic and therapeutic challenges. In an advanced state, they have an increased risk of perforation and a high mortality rate. The surgical therapeutic approach has a high perioperative complication rate. In this study, we report a case of a thoracic mycotic aortic aneurysm in an immunocompromised pediatric patient caused by Klebsiella pneumoniae bacteremia. A combination of prompt antibacterial treatment and minimally invasive stent implantation showed a good outcome, avoiding possible severe surgical problems.
Effect of tetracycline hydrochloride application on dental pulp stem cell metabolism–booster or obstacle for tissue engineering?
Authors: Wang Wang , Sun Jiangling , Aarabi Ghazal , Peters Ulrike , Fischer Frank , Klatt Jan , Gosau Martin , Smeets Ralf , Beikler Thomas
Published: September 2023

Introduction: Stem cells and scaffolds are an important foundation and starting point for tissue engineering. Human dental pulp stem cells (DPSC) are mesenchymal stem cells with self-renewal and multi-directional differentiation potential, and are ideal candidates for tissue engineering due to their excellent biological properties and accessibility without causing major trauma at the donor site. Tetracycline hydrochloride (TCH), a broad-spectrum antibiotic, has been widely used in recent years for the synthesis of cellular scaffolds to reduce the incidence of postoperative infections.

Methods: In order to evaluate the effects of TCH on DPSC, the metabolism of DPSC in different concentrations of TCH environment was tested. Moreover, cell morphology, survival rates, proliferation rates, cell migration rates and differentiation abilities of DPSC at TCH concentrations of 0–500 μg/ml were measured. Phalloidin staining, live-dead staining, MTS assay, cell scratch assay and real-time PCR techniques were used to detect the changes in DPSC under varies TCH concentrations.

Results: At TCH concentrations higher than 250 μg/ml, DPSC cells were sequestered, the proportion of dead cells increased, and the cell proliferation capacity and cell migration capacity decreased. The osteogenic and adipogenic differentiation abilities of DPSC, however, were already inhibited at TCH con-centrations higher than 50 μg/ml. Here, the expression of the osteogenic genes, runt-related transcription factor 2 (RUNX2) and osteocalcin (OCN), the lipogenic genes lipase (LPL), as well as the peroxisome proliferator-activated receptor-γ (PPAR-γ) expression were found to be down-regulated.

Discussion: The results of the study indicated that TCH in concentrations above 50 µg/ml negatively affects the differentiation capability of DPSC. In addition, TCH at concentrations above 250 µg/ml adversely affects the growth status, percentage of living cells, proliferation and migration ability of cells.
Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies
Authors: Saravanan Harish , Subramani Tarunkarthick , Rajaramon Shobana , David Helma , Sajeevan Anusree , Sujith Swathi , Solomon Adline Princy
Published: September 2023

Nanocomposites, formed by combining a matrix (commonly polymer or ceramic) with nanofillers (nano-sized inclusions like nanoparticles or nanofibers), possess distinct attributes attributed to their composition. Their unique physicochemical properties and interaction capabilities with microbial cells position them as a promising avenue for infectious disease treatment. The escalating prevalence of multi-drug resistant bacteria intensifies the need for alternative solutions. Traditional approaches involve antimicrobial agents like antibiotics, antivirals, and antifungals, targeting specific microbial aspects. This review presents a comprehensive overview of diverse nanocomposite types and highlights the potential of tailored matrix and antibacterial agent selection within nanocomposites to enhance treatment efficacy and decrease antibiotic resistance risks. Challenges such as toxicity, safety, and scalability in clinical applications are also acknowledged. Ultimately, the convergence of nanotechnology and infectious disease research offers the prospect of enhanced therapeutic strategies, envisioning a future wherein advanced materials revolutionize the landscape of medical treatment.
Does childhood psychological maltreatment encourage you to become a cyberbullying perpetrator? The mediating role of negative affect and the moderating role of meaning in life
Authors: Zhang Shujing , Li Yi , Cao Min , Liu Yuxiao , Zhou Zongkui
Published: September 2023

Objective

With the development of information and communication technology, cyberbullying among Chinese college students has become more frequent, bringing many negative consequences to both society and students themselves. Childhood psychological maltreatment may be one of the influencing factors of cyberbullying, but its internal mechanism remains poorly understood. This study aimed to explore the relationship between childhood psychological maltreatment and cyberbullying among college students and to further explore the mediating effect of negative emotion and the moderating effect of meaning in life.

Methods

In this study, 656 college students (48.7% males) were recruited to complete anonymous questionnaires assessing their perceptions of child psychological maltreatment, negative affect, meaning in life and cyberbullying. SPSS23.0 and Hayes PROCESS macro for SPSS were used to conduct statistical analysis.

Results

(1) Childhood psychological maltreatment was significantly positively associated with cyberbullying; (2) Negative affect played a partially mediating role between childhood psychological maltreatment and cyberbullying; and (3) Meaning in life moderated the direct association between childhood psychological maltreatment and cyberbullying and moderated the association between negative affect and cyberbullying.

Conclusion

In this study, a moderated mediation model was constructed and the internal mechanism of childhood psychological maltreatment and cyberbullying among college students was found. The results provided both theoretical contributions and practical suggestions for preventing cyberbullying.
What’s love got to do with jealousy?
Authors: Fernandez Ana Maria , Barbato Maria Teresa , Cordero Belen , Acevedo Yvone
Published: September 2023

Romantic love and jealousy seem antagonistic, but the expression of both emotions have evolutionary functions that can go in the same direction of maintaining a relationship. Considering natural selection designed adaptations to solve the problems surrounding reproduction, then love and romantic jealousy are emotions aimed at staying cooperative for a period of time, where love solves the adaptive challenges of promoting pair bonding, cooperation, and protecting offspring; and jealousy is triggered by a threat or the loss of a valuable cooperative relationship, either on behalf of descendants in need of resources, or a close romantic bond. Consequently, understanding love and romantic jealousy points in the same adaptive functional domain of protecting a romantic pair bond. Specifically, love can be comprehended in two different ways and in regard to jealousy. First, conceiving love as the attachment to significant others one develops throughout lifetime, and secondly, it contemplates affective dependence. Results from a sample of single and committed individuals (n = 332) show the predicted positive correlation between attachment and jealousy as stable traits, consistent with previous literature. In addition, there is a non-significant and low correlation, respectively, between attachment and love as a measure of dependence. Furthermore, in the single participants group, jealousy was associated with love. The discussion emphasizes the need for expanding a functional account of love and jealousy as complementary emotions of our human affective endowment. Finally, it would be informative to study attachment as a relational trait and love as a specific affection for a romantic partner that could be manipulated to elucidate the functional design of jealousy.
Tautological formal explanations: does prior knowledge affect their satisfiability?
Authors: Aslanov Ivan , Guerra Ernesto
Published: September 2023

It is known that formal explanations with categorical labels are more satisfying than explicit tautologies. However, would they still be more satisfying if they are implicitly tautological themselves? In two experiments, we compared the degree of satisfaction between tautological formal explanations, explicit tautologies, and proper explanations. Additionally, we examined whether participants knew the correct definitions for the labels used in the formal explanations. Finally, we asked whether cultural and linguistic differences can play a role in the treatment of formal explanations with categorical labels. To this end, the first experiment involved Chilean students (N = 50), and the second experiment involved Russian students (N = 51). It was found that formal explanations, despite their intentional tautology, were still rated as more convincing compared to explicit tautologies (but less convincing than proper explanations). Furthermore, this effect did not depend on participants’ previous knowledge (the label’s definitions) or linguistic and cultural background. Taking all this into account, we consider this effect as a relatively universal psychological phenomenon and relate our findings to existing theories of formal explanations.
Case report: A community case study of the human-animal bond in animal-assisted therapy: the experiences of psychiatric prisoners with therapy dogs
Authors: Smith Sonia , Dell Colleen Anne , Claypool Tim , Chalmers Darlene , Khalid Aliya
Published: September 2023

Prisoners frequently experience chronic loneliness and lack social support, which can exacerbate their struggles with incarceration. According to attachment theory, individuals who are insecurely attached may be more likely to develop unstable relationships and engage in antisocial behavior as adults. In 2015 an animal-assisted therapy (AAT) program was implemented in a Canadian forensic psychiatric facility/prison, a “hybrid” facility that adheres to federal legislation regarding correctional services but follows provincial mental health legislation. The program centers on the development of a human-animal bond (HAB), which serves as a connection between the animals and prisoners. The HAB also addresses issues related to toxic masculinity, which are often present among men incarcerated in correctional facilities, including psychiatric prisons. An instrumental community case study design involving 6 prisoners at a forensic psychiatric facility/prison over 24 AAT sessions between 2015–2019 was undertaken. Interviews with the prisoners and their mental health clinicians were thematically analyzed to explore how the HAB was experienced as a form of attachment. Four themes emerged: safety, physical touch, reciprocity, and acceptance. These themes suggest that the therapy dogs have the potential to serve as a surrogate attachment figure for prisoners, mitigating their experiences of disconnection and fostering their development of interpersonal connections. This suggests attachment theory underpins the HAB and highlights the contribution of AAT practice and research in forensic psychiatric facilities/prisons. This study also suggests that the program's offering of prosocial support and nurturance/caring aligns with the specific criminogenic risks and needs identified within Correctional Service Canada's Risk-Need-Responsivity (RNR) model for rehabilitation. Continued research and attention should be paid to AAT programs as a valuable addition to the range of support networks available to prisoners in psychiatric or non-psychiatric institutions.
The health literacy level and its related factors in Iranian women with breast cancer undergoing chemotherapy
Authors: Sadeghian Reyhaneh , Hamedani Mahsa Asadollahi , Salehipour Sajad , Sarabandi Anahita , Kiani Fatemeh , Babamohamadi Hassan
Published: September 2023

Background

Breast Cancer (BC) is the most common cause of female mortality throughout the world. Promoting public awareness about this disease is the most crucial method of its prevention or control. The present study was carried out to determine the health literacy level and its related factors in women with BC.

Methods

This cross-sectional study was conducted on BC patients undergoing chemotherapy in two teaching hospitals affiliated to Zahedan University of Medical Sciences in 2020. A total of 210 patients referred to these chemotherapy centers were selected by purposive sampling. The data collection tools included a demographic information form and a health literacy questionnaire for Iranian women with BC. The collected data were analyzed using descriptive and inferential statistics (logistic regression) in SPSS-22. p-values less than 0.05 were considered statistically significant.

Results

The mean total score of the health literacy of women with BC undergoing chemotherapy was 40.35 ± 19.01, which suggests an insufficient health literacy. The health literacy had a significant relationship with variables including university education (OR = 4.41, p = 0.005) and supplementary insurance coverage (OR = 5.83, p < 0.001).

Conclusion

The findings showed that university education and supplementary insurance coverage are associated with a higher health literacy among women with BC. Improving these factors and paying further attention to their role in the promotion of health literacy can help enhance the health literacy of women with BC.
Association of physical activity and PM2.5-attributable cardiovascular disease mortality in the United States
Authors: Liu Yingying , Yan Mengmeng
Published: September 2023

Objective

The study aimed to explore the association between physical activity (PA) and PM2. 5-attributable cardiovascular disease (CVD) mortality trends across the United States (US) at the state level.

Methods

We conducted a cross-sectional study using data from the Global Burden of Disease 2019 study for PM2.5-attributable CVD mortality and the Behavioral Risk Factor Surveillance System for PA prevalence. The study covered all 50 US states and the District of Columbia from 2001 to 2019. We utilized Joinpoint Regression to calculate AAPC from 2011 to 2019 and Pearson correlation coefficients to assess state-level associations between PA and PM2.5-attributable CVD mortality AAPC.

Results

During 2011–2019, a total of 244,318 PM2.5-attributable CVD deaths were recorded. The age-adjusted mortality rates (AAMR) of PM2.5-attributable CVD declined substantially from 2011 to 2019 across all US states, with the most pronounced reductions observed in industrialized states such as West Virginia (51% decline), Kentucky (32%), and Ohio (22%). AAMR ratios for the US states varied substantially, ranging from 0.1 in Hawaii to 1.7 in Arkansas. The AAPC ranged from −9.4% (West Virginia) to −1.7% (New Mexico) in the majority of states, while a few states such as Alaska, Wyoming, and Washington saw slight positive AAPCs from 0.9 to 2.9%. A significant correlation was found between PA and PM2.5-attributable CVD mortality trends (r = 0.454, p = 0.001), with similar results in subgroup analyses.

Conclusion

Our findings suggest a correlation between increased physical activity (PA) and increased PM2.5-attributable CVD mortality, highlighting the potential need to consider PM2.5 exposure when engaging in PA to mitigate adverse cardiovascular health impacts. However, further research is warranted to establish causality and underlying mechanisms in the relationship between PA and PM2.5-attributable CVD mortality. Potential limitations include reliance on self-reported PA data.
Integrating sustainability in the design process of urban service robots
Authors: van der Schoor Michel Joop , Göhlich Dietmar
Published: September 2023

The concept of sustainability and sustainable development has been well discussed and was subject to many conferences of the EU and UN resulting in agendas, goals, and resolutions. Yet, literature shows that the three dimensions of sustainability (ecological, social, and economic) are unevenly accounted for in the design of mechatronic products. The stated reasons range from a lack or inapplicability of tools for integration into the design process, models for simulation, and impact analyses to necessary changes in policy and social behavior. The influence designers have on the sustainability of a product lies mostly in the early design phases of the development process, such as requirements engineering and concept evaluation. Currently, these concepts emerge mostly from performance-based requirements rather than sustainability impact-based requirements, which are also true for service robots in urban environments. So far, the main focus of research in this innovative and growing product branch lies in performance in perception, navigation, and interaction. This paper sets its focus on integrating all three dimensions of sustainability into the design process. Therefore, we describe the development of an urban service robot supporting municipal waste management in the city of Berlin. It is the set goal for the robot to increase the service and support the employees while reducing emissions. For that, we make use of a product development process (PDP) and its adaptable nature to build a specific development process suited to include the three dimensions of sustainability during the requirements engineering and evaluation activities. Herein, we show how established design methods like the life cycle assessment or life cycle costing can be applied to the development of urban service robots and which aspects are underrepresented. Especially, the social dimension required us to look beyond standardized methods in the field of mechanical engineering. Based on our findings, we introduce a new activity to the development process that we call preliminary social assessment in order to incorporate social aspects in the early design phase.
Recent insights on CME deflections at low heights
Authors: Cécere M. , Costa A. , Cremades H. , Stenborg G.
Published: September 2023

It has been shown that the magnetic structures surrounding coronal mass ejection (CME) events play a crucial role in their development and evolution along the first few solar radii. In particular, active regions, coronal holes, pseudostreamers, and helmet streamers are among the main coronal structures involved in the deviation of the trajectory of CMEs from their radial direction. Therefore, comprehensive observational studies along with their theoretical interpretation, aided by numerical simulations of the early evolution of CMEs, are the key ingredients to help determine their 3D trajectory in the interplanetary medium to narrow down the error in the estimation of the time of arrival of geoeffective events. In this mini-review, we compile the last decade of theoretical, numerical, and observational research that has shed light on the causes influencing the early deflection of CMEs away from their otherwise radial trajectory.
Status of integrated crop-livestock research in the mixed farming systems of the Global South: a scoping study
Authors: Mabhaudhi Tafadzwanashe , Chibarabada Tendai Polite , Sikka Alok
Published: September 2023

Mixed farming systems (MFS) are the main food source and exist across almost all agroecological regions in the Global South. A systematic scoping review was conducted to identify the status of integrated crop-livestock research in MFS of the Global South. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol was used to identify 210 studies (excluding reviews) addressing productivity, resilience, challenges, opportunities, and perceptions of integrating crops and livestock in the Global South from the Scopus and Web of Science database. Publication details, problem statement, experimental details and research outcomes of each study were extracted into an MS. Excel sheet. Descriptive methods such as frequency counting and the word frequency cloud were used to analyze the data and identify emerging themes. Integrated crop-livestock research was mostly conducted in sub-Saharan Africa and Asia and not much from North Africa and the Caribbean. The integrated research has been focused on farm production of human food and animal feed by smallholder farmers and soil productivity. Maize was the most dominant crop, while for livestock, it was sheep and cattle. The integrated crop-livestock research seeked to address various challenges, including the growing demand for food and fodder, water scarcity, land scarcity and degradation, climate change, disease outbreaks and social changes. The review summarized proposed strategies and approaches to improve the efficiency of MFS in the Global South. Under the current challenges, feed quality and supply can be improved through adoption of high biomass, climate smart and improved drought-tolerant fodder crops. Using crop residues incorporated in crop fields for improved soil organic matter and controlled grazing were some strategies suggested for land rehabilitation. Building the resilience of smallholder farmers in MFS can be done through diversification and ensuring access to information, markets and finance. Policies that promote the business component, i.e., markets, training, gender equality, private investments, tenure systems and technology adoption were identified for the sustainability of MFS. There is need for research that integrates crop-livestock systems and natural resource management innovations and that evaluates sustainable intensification strategies to meet productivity goals without compromising social and ecological outcomes in MFS.
Case report: Novel transtemporal transverse sinus decompression surgery to alleviate transverse sinus stenosis in a pulsatile tinnitus patient with restricted bilateral venous outflow
Authors: Hsieh Yue-Lin , Wang Wuqing
Published: September 2023

Transverse sinus (TS) stenosis is common in individuals with venous pulsatile tinnitus (PT). While PT can be addressed by endoluminal or extraluminal methods, the former has shown promise in alleviating symptoms associated with increased intracranial pressure. This study explores the potential of extraluminal methods to alleviate TS stenosis and eliminate PT caused by sigmoid sinus diverticulum. A 31-year-old male patient presenting with left-sided PT, attributed to a large, pedunculated sigmoid sinus diverticulum along with severe ipsilateral TS stenosis and contralateral TS hypoplasia, underwent ipsilateral extraluminal TS decompression surgery following sigmoid sinus wall reconstruction under local anesthesia. Postoperative CT and MR angiography revealed a significant increase in the TS lumen from 0.269 to 0.42 cm2 (56.02%) 2 years after surgery. Cervical Doppler ultrasound demonstrated a 36.07% increase in ipsilateral outflow volume to 16.6 g/s and a 77.63% increase in contralateral outflow volume to 1.35 g/s. In conclusion, this pioneering study showcases the potential of transtemporal TS decompression surgery in creating space for adaptive expansion of the TS lumen. However, the procedure should be reserved for individuals with severely compromised venous return.