bluuebunny/crossref_metadata_2025 huggingface dataset:
Transitioning Parenteral or Inhaled Treprostinil to Oral Treprostinil Diolamine: Case Series and Review of the Literature
Authors: Smith Zachary R. , Kelly Bryan , Awdish Rana L. , Hegab Sara
Published: March 2018

Treprostinil diolamine is the first oral dosage preparation of a prostacyclin analogue for use in treatment naive pulmonary arterial hypertension (PAH). This case series and review of the available literature describes the experience of patients with PAH receiving treprostinil by intravenous (IV), subcutaneous (SQ), or inhalation route who were transitioned to treprostinil diolamine. At our institution, 3 patients were transitioned to treprostinil diolamine who received treprostinil administered by each of the alternative routes: IV, SQ, and inhalation. All patients tolerated the transition without significant worsening of disease end points. In the literature, 5 additional reports representing 48 patients were transitioned to treprostinil diolamine from an alternate route of administration. A majority (92%) of patients were hospitalized during the cross-titration phase and tolerated the transition without changes in disease markers or significant adverse effect. Six (13%) patients required reinitiation of parenteral therapy due to clinical decline. The most common dosing frequency utilized for treprostinil diolamine was 3 times per day. In patients with stable PAH receiving parenteral or inhaled treprostinil, a transition to treprostinil diolamine was a safe approach in a highly select population meeting clinical end points. Additional studies are required to further describe this clinical strategy before accepted in clinical practice.
Influence of antioxidant addition on the emissions of a diesel engine by using waste cooking oil biodiesel
Authors: Halek Farah , Kavousi-Rahim Ali
Published: March 2018

Biodiesel is a renewable energy resource consisting of the alkyl monoesters of fatty acids obtained from vegetable oils, waste cooking oils, or animal fats. Biodiesel has been noticed recently as an alternative to fossil fuels. Previous studies have shown that biodiesel produces less pollutants compared to diesel fuel. Biodiesel fuel increases the emission of NOx exceptionally. Recently, it has been found that antioxidant addition to biodiesel is a solution to solve the problem. The purpose of this research is to study the effect of antioxidants addition on the emissions of CO, HC, and NOx from biodiesel fuel. Exhaust emissions of an agriculture diesel engine were studied using biodiesel blend with a 500 ppm propyl gallate (PrG) (propyl-3,4,5-trihydroxybenzoate) and butylated hydroxy anisole (BhA) (2-tert-butyl-4-methoxyphenol) as two major antioxidants. Biodiesel used in this research was prepared through NaOH catalyzed transesterification of a waste cooking oil that originally was taken from sunflower oil, with the assistance of ultrasonic homogenizer. After biodiesel production, five blends including neat diesel, B10, B20, B20 + 500 ppm PrG, and B20+ 500 ppm BhA were used as fuel and the emitted gases were analyzed. The results of this work demonstrated that the addition of antioxidants has no significant effect on lowering CO emission, as well as lowering HC; but the addition of antioxidants results in more efficient reduction of NOx emission from diesel exhaust. In general, BhA showed better results compared to PrG.
Same but different: Polish and Norwegian parents’ work–family adaptations in Norway
Authors: Bjørnholt Margunn , Stefansen Kari
Published: March 2018

This article explores how families with young children arrive at and live with different work–family adaptations within a welfare state that strongly supports the dual earner/dual carer model – that of Norway. It draws on a qualitative study among Norwegian-born and Polish-born parents, representing, respectively, ‘insider’ and ‘outsider’ views on this model. The analysis aims at capturing the dynamic interplay between structures and policies, and everyday practices. We found that both Norwegian and Polish parents embraced the cultural ideal of the dual earner/dual carer model, but that their perceived scope of action differed. Within the Norwegian group, there were differences related to class, however. Among middle-class Norwegian parents, the model was internalized as a moral obligation and part of identity, making it difficult to voice and cope with work–family conflict. Working-class parents in this group varied more in their identification with this model. Across class, Polish parents, in contrast, used welfare state entitlements eclectically to shape new and more gender equal family practices in Norway and to adjust to changing circumstances. The article illustrates how enabling structures may represent both opportunities for and limitation to individual agency, undermining the assumption of a simple ‘fit’ between work–family policies, work–family adaptations and gender equality in the family.
When social support by patrons protects against burnout: A study among Italian public library workers
Authors: Martini Mara , Viotti Sara , Converso Daniela , Battaglia Jolanda , Loera Barbara
Published: March 2018

The study aimed to measure burnout among librarians in a city in Northern Italy, and to identify which demands and resources influence emotional exhaustion and cynicism. In particular, it focused on the relationship with patrons, since in the service sector users are mostly studied as a cause of stress and rarely considered as a source of support for service operators. Hierarchical regressions carried out on data (167 self-administered questionnaires) showed that burnout dimensions are influenced by some socio-demographic and job characteristics, and by the positive and negative aspects of relationships with users. We present some practical implications for library managers, in order to reduce the impact of their patrons’ negative behaviour and to improve conditions to facilitate the expression of users’ support for workers.
Mucormycosis: Early Identification of a Deadly Fungus
Authors: Brettholz Ariel M. , Mccauley Sabrina Opiola
Published: March 2018

Mucormycosis is a rare invasive fungal infection that affects immunocompromised patients and is fatal when not identified and treated early. Diagnosis is often delayed as the symptoms are nonspecific and frequently mimic other common diseases. Pediatric patients with cancer are at risk for the infection; however, there is limited research that applies directly to the pediatric population. An understanding of the risk factors and clinical presentation of mucormycosis is crucial for the pediatric oncology provider to initiate the workup and provide prompt treatment. The gold standard for diagnosing mucormycosis is biopsy; however, the use of polymerase chain reaction is a novel tool that is being investigated. The mainstays of treatment are antifungal medications, surgery, and reversal of predisposing risk factors, although, new therapies are also emerging. This article will review the pathophysiology, clinical manifestations, and diagnostics of mucormycosis and will discuss current treatment and management strategies for the pediatric oncology clinician to allow for timely diagnosis and intervention to optimize patient outcomes.
Assessment and Management of Psychosocial Needs
Authors: Kaye Alison , Lybrand Sandra , Chew William L.
Published: March 2018

Objective:

To determine family-reported psychosocial stressors and social worker assessments and interventions within a comprehensive cleft team.

Design:

Single-institution prospective provider-completed survey.

Patients:

Four hundred one families seen by cleft team social worker over a 7-month period.

Results:

Most families (n = 331; 83%) participated in the team social work assessment. At least 1 active psychosocial stressor was reported by 238 (72%) families, with 63 (19%) families reported 3 or more stressors. There were 34 types of stressors reported. Most common were financial strain, young age of patient, new cleft diagnosis, and distance from clinic (57% of families live over an hour away). Family structure and home environment were assessed in detail for 288 (87%) families. Detailed assessments for access to care and behavioral/developmental issues also figured prominently. Social work interventions were provided in 264 (80%) of the visits, of which 91 were for families of new patients with over half who had infants less than 3 months old. Of the 643 interventions provided, the most frequent were parent mental health screens and counseling, early intervention referrals, transportation assistance, securing local hotel discounts, orthodontic referrals, and orthodontic cost coverage. Approximately 10% of encounters required follow-up contact related to the psychosocial concerns identified in clinic.

Conclusions:

The inclusion of a cleft team social worker is a critical component of comprehensive cleft team care as evidenced by the large proportion of families who required assistance. Ongoing social work assessments are recommended for each patient to help address the variety of psychosocial stressors families face.
Voice Quality in Adults Treated for Unilateral Cleft Lip and Palate
Authors: Morén Staffan , Lindestad Per Åke , Holmström Mats , Mani Maria
Published: March 2018

Objectives:

The aim of the current study was to assess voice quality among adults treated for unilateral cleft lip and palate (UCLP), after one- or two-stage palate closure, and compare it to a noncleft control group.

Study Design:

Cross-sectional study of patients with UCLP with long-term follow-up and noncleft controls.

Participants:

Patients with UCLP born between 1960 and 1987, treated at Uppsala University Hospital, Sweden, were examined (n = 73) at a mean of 35 years after primary surgery. Forty-seven (64%) patients had been treated with 1-stage palate closure and 26 with 2-stage closure (36%). The noncleft control group consisted of 63 age-matched volunteers.

Main Outcome Measures:

Ratings of perceptual voice characteristics from blinded voice recordings with Swedish Voice Evaluation Approach method. Acoustic voice analysis including pitch and spectral measures.

Results:

Among the patients, the mean values for the 12 evaluated variables on a visual analog scale (0 = no abnormality, 100 = maximal abnormality) ranged between 0.1 and 17, and the mean for all was 6 mm. Voice variables were similar between patients and controls, except the total mean of all the perceptual voice variables, as well as “vocal fry”; both slightly lower among patients ( P = .018 and P = .009). There was no difference in any variable between patients treated with 1-stage and 2-stage palate closure. No clear relationship was found between velopharyngeal insufficiency and dysphonia.

Conclusions:

The voice characteristics among adults treated for UCLP in childhood are not different from those of individuals without cleft.
Isavuconazole therapy in an FLT3 mutated acute myeloid leukemia patient receiving midostaurin: A case report
Authors: Tollkuci Eris
Published: March 2018

Midostaurin is the first approved FMS-related tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 mutated acute myeloid leukemia. Midostaurin is a major cytochrome P450 3A4 (CYP3A4) substrate. Coadministration with a strong CYP3A4 inhibitor or inducer can lead to a potential increase or decrease in midostaurin exposure. This report describes a 43-year-old patient with FLT3-internal tandem duplication (FLT3-ITD) positive acute myeloid leukemia who initially presented with leukocytosis and concern for acute leukemia. Following the initiation of induction chemotherapy, the patient developed lung nodules concerning for a fungal infection. Isavuconazole, a moderate CYP3A4 inhibitor, was successfully initiated and maintained, while midostaurin therapy was also administered. Clinicians should be aware and exercise caution when using midostaurin with CYP3A4 inhibitors and inducers.
Parental Emotion Regulation and Mentalization in Families of Children With ADHD
Authors: Gershy Naama , Gray Sarah A. O.
Published: March 2018

Objective: The aim of this study is to examine the role of parental emotion regulation (ER) and parental mentalization as possible contributors to hostile and coercive parenting in families of children with ADHD. Method: Seventy-four Israeli families (64 mothers and 48 fathers) seeking parent training for child ADHD completed measures during the intake session. Measures included parental ER; parental mentalization; hostile, coercive, and submissive parenting; and child symptoms. Results: Findings suggested a relationship between parental ER and coercive parenting independent of child age, symptom level, and parental mentalization. Parental mentalization appeared to buffer against hostility specifically among parents with low ER capacities. Patterns were parallel for mothers and fathers. Conclusion: Study findings highlight the importance of evaluating and addressing parental ER in interventions attempting to reduce coercive parenting. The findings also highlight the potential role of parental mentalization as a protective mechanism against hostile parenting in families of children with ADHD.
Insertion site assessment of peripherally inserted central catheters: Inter-observer agreement between nurses and inpatients
Authors: Webster Joan , Northfield Sarah , Larsen Emily N , Marsh Nicole , Rickard Claire M , Chan Raymond J
Published: March 2018

Introduction:

Many patients are discharged from hospital with a peripherally inserted central catheter in place. Monitoring the peripherally inserted central catheter insertion site for clinical and research purposes is important for identifying complications, but the extent to which patients can reliably report the condition of their catheter insertion site is uncertain. The aim of this study was to assess the inter-observer agreement between nurses and patients when assessing a peripherally inserted central catheter site.

Methods:

The study was based on inpatients who were enrolled in a single-centre, randomised controlled trial comparing four different dressing and securement devices for peripherally inserted central catheter sites. A seven-item peripherally inserted central catheter site assessment tool, containing questions about the condition of the dressing and the insertion site, was developed. Assessment was conducted once by the research nurse and, within a few minutes, independently by the patient. Proportions of agreement and Cohen’s kappa were calculated.

Results:

In total, 73 patients agreed to participate. Overall, percentage agreement ranged from 83% to 100% (kappa = .65–.82). For important clinical signs (redness, swelling, ooze, pus and tracking), there were high levels of percentage agreement (99%–100%).

Conclusion:

The high level of agreement between nurse/patient pairs make the instrument useful for assessing peripherally inserted central catheter–associated signs of localised infection, allergic or irritant dermatitis or dressing dislodgement in a community setting.
Effect of catheter diameter on left innominate vein in breast cancer patients after totally implantable venous access port placement
Authors: Song Myung Gyu , Seo Tae-Seok , Kim Yun Hwan , Cho Sung Bum , Chung Hwan Hoon , Lee Seung Hwa , Jung Euichul
Published: March 2018

The effect of catheter diameter on left innominate vein stenosis in breast cancer patients after totally implantable venous access port placement.

Purpose:

To evaluate the effect of catheter diameter on left innominate vein stenosis in breast cancer patients after placement of totally implantable venous access ports.

Materials and methods:

Totally implantable venous access ports were placed via the left internal jugular vein in 241 women with right breast cancer from January 2010 to December 2014 (mean age, 51.5 years; range, 19–83 years). There were 67 totally implantable venous access ports with a 6.5F catheter and 142 totally implantable venous access ports with an 8F catheter. Medical records were retrospectively reviewed. The presence of significant left innominate vein stenosis and tip location of the catheter was evaluated on chest computed tomography images. Statistical analysis was performed.

Results:

Left innominate vein stenosis developed in 1 (1.5%) and 13 (9.2%) patients after implantation with 6.5 and 8F catheters, respectively. Difference in the cumulative incidence of left innominate vein stenosis was statistically significant between the two groups (log rank test p-value: 0.002). In Cox regression analysis, the hazard ratio for left innominate vein stenosis was 20.766 ( p = 0.005) for an 8F catheter.

Conclusion:

The incidence of left innominate vein stenosis was higher after implantation of totally implantable venous access ports with 8F catheter rather than with 6.5F catheter. Considering that using 8F catheter versus 6.5F catheter has no advantage in terms of performance of the device, the results of our study suggest that ports with catheters >7F should be avoided.
Chitosan Membrane Embedded With ZnO/CuO Nanocomposites for the Photodegradation of Fast Green Dye Under Artificial and Solar Irradiation
Authors: Alzahrani Eman
Published: March 2018

Fast Green (FCF) dye is commonly used in both cytology and histology applications. Previous studies have found that it can cause mutagenic and tumorigenic effects in experimental human and animal populations. It can also be a source of skin, eye, respiratory, and digestive irritation. The purpose of this study was to examine the use of thin film membranes to degrade FCF. A thin film membrane of chitosan (CS) was fabricated and subsequently filled with zinc oxide nanoparticles (ZnO) or ZnO/CuO-heterostructured nanocomposites. The CS membrane was used as a matrix, and the nanomaterials were used as photocatalysts. The prepared membranes were characterised by four analytical techniques: atomic force microscopy, scanning electron microscopy, X-ray diffraction, and energy-dispersive X-ray analyses. The photocatalytic activity of the fabricated membranes was evaluated by performing experiments in which aqueous solutions of FCF dye that contained the fabricated membrane were irradiated with solar light or UV light. The photodegradation percentage was spectrophotometrically determined by monitoring the maximum wavelengths (λmax) of FCF at 623 nm for different irradiation times. The decolourisation percentages of the dye under solar light were 57.90% and 60.23% using the CS-ZnO and CS-ZnO/CuO membranes, respectively. When UV light irradiation was employed as the source of irradiation, the photodegradation percentages of FCF were 71.45% and 91.21% using the CS-ZnO and CS-ZnO/CuO membranes, respectively. These results indicated that the best photocatalytic system for the degradation of FCF dye was CS-ZnO/CuO membrane in combination with UV light irradiation. The study also found that it was easy to separate the prepared membranes after the reaction without the need for a centrifuge or magnet. The results demonstrate the potential for CS-ZnO and CS-ZnO/CuO membranes for use as effective sorbents during the process of photodegradation of harmful dyes within waste water recycling practices.
Evading Time and Place in Ankara: A Reading of Contemporary Urban Collective Memory Through Recent Transformations
Authors: Sak Segah , Senyapili Burcu
Published: March 2018

Based on precedent theories on collective memory and urban studies, this article develops a framework of approach to contemporary urban collective memory. Understanding urban collective memory by handling people and urban space as a system provides a sociospatial perspective for critical approaches to cities. The study initially provides overviews of theoretical approaches to collective memory and city, and then puts forth constituents of urban collective memory. Based on these constituents, contemporary urban collective memory is discussed, and a framework for analyzing contemporary cities in terms of urban space and urban experience is introduced. For a clear portrayal of urban issues within the context, the introduced framework is devised through the case of Ankara, the capital city of Turkey and the inspiring force behind this study. This framework aims to present a ground to assess people’s relation to urban spaces in the contemporary era.
Excelsior-Henderson motorcycles: Could lean start-up methodology have averted a $100-million Mistake?
Authors: Clement Tom
Published: March 2018

This case applies the recently proposed lean start-up methodology to the failed Excelsior-Henderson Motorcycle Manufacturing Company. Company founder Dan Hanlon and his family pursued a dream to start a new American motorcycle company based largely on market leader Harley-Davidson’s inability to meet customer demand. Excelsior-Henderson’s founders followed a path of crafting and executing an elaborate business plan filled with goals and assumptions, with no customer discovery, validation, or iterative testing performed. The result was misjudging the complexities and financial demands of the motorcycle industry and an ultimate lack of customer response which led to a loss of US$100 million in capital and eventual bankruptcy. Students will learn to evaluate the challenges start-ups face through the lens of the lean start-up method, including customer discovery and the consideration of a minimum viable product (MVP).
What is the point of religious education?
Authors: Clayton Matthew , Stevens David
Published: March 2018

Some liberal societies continue to require their schools to offer non-directive but, specifically, religious education as part of the curriculum. This article challenges that practice. It does so by articulating and defending the moral requirement that education policy must be regulated by principles that are acceptable to reasonable people. Thereafter, we argue that the leading arguments for prioritizing the study of religion in schools – arguments that claim that religion is special or that assert that the majority or parents are morally permitted to prioritize religion in schooling – are incompatible with the acceptability requirement.
AgNps-PVA–coated woven cotton fabric: Preparation, water repellency, shielding properties and antibacterial activity
Authors: Xu Jiangtao , Jiang SX , Peng Linghui , Wang Yuxiang , Shang Songmin , Miao Dagang , Guo Ronghui
Published: March 2018

Nowadays, there is a large demand for smart textiles by consumers. Smart textiles have different functions, and can provide comfort, safety and protection. In this study, electro-conductive woven cotton fabric is prepared in two steps. The cotton fabric samples are first impregnated and padded with a polyvinyl alcohol solution of 5% for multiple cycles (1, 3, 5 and 7 cycles) and dried. Then, silver nanoparticles are deposited onto the fabric through magnetron sputtering technology. The coated samples are examined using a Fourier transform infrared spectrometer, scanning electron microscope and X-ray diffractometer. The ultraviolet blocking, infrared reflection, electromagnetic shielding, and antibacterial properties are evaluated, as well as the contact angle, light transmittance and electrical conductivity. The results show that a polyvinyl alcohol film is successfully formed and the cotton fabric fibers are stuck together through hydrogen bonds. The light transmittance is increased after the polyvinyl alcohol pretreatment. After undergoing seven cycles of coating with polyvinyl alcohol, the silver nanoparticles-coated samples show large contact angle of 127.6°, excellent ultraviolet blocking property, a high infrared reflectivity of 30%, electrical resistivity of 1.46 × 10–6 Ω·m, electromagnetic interference shielding effectiveness of −20 dB and antibacterial efficacy of >99.5%. Compared to the untreated and silver-coated cotton without impregnation of polyvinyl alcohol, the silver nanoparticles–polyvinyl alcohol-coated cotton fabric sample has excellent performance, which makes it a promising textile with a multitude of protective properties.
Addressing the Practice-to-Research Gap: A Rigorous Evaluation of Local Education Agency–Based Interventions for Struggling Readers in Sixth Grade
Authors: Crone Deanne A. , Stoolmiller Michael , Baker Scott K. , Fien Hank , Turtura Jessica , Strand Cary Mari , Kennedy Patrick C. , Nelson Nancy , Kame’enui Edward J.
Published: March 2018

We present the results of a study of local education agency (LEA)-based interventions to improve the reading outcomes of struggling readers in sixth grade. The sample included 1,076 intervention students and 3,644 comparison students. Regression discontinuity was used to evaluate intervention impact. The study contributes to the field by demonstrating (a) the importance of conducting rigorous evaluations of existing school interventions to understand the true impact of evidence-based practices when implemented under local circumstances and constraints, and (b) the use of regression discontinuity as an evaluation design is feasible within typical school settings. Implications for the study are discussed, especially in terms of providing a model for evaluation of LEA-driven interventions in the middle grades.
Factors Protecting Male and Female Adolescents in Mexico From Human Papillomavirus Infection
Authors: Gómez Claudia Orozco , Champion Jane Dimmitt , Monsiváis María Guadalupe Moreno
Published: March 2018

Introduction:

Adolescents may be infected with human papillomavirus (HPV) during their first sexual relationship. Persistent infections in adulthood may result in associated cancers among both women and men. This study explored condom use action plans, its influence on sexual activity in adolescents, and associated HPV protective behavior.

Methods:

A descriptive correlational design was used. A convenience sample including adolescents ( N =313; male n = 171, female n = 142), aged 15 to 17 years, attending one of three public high schools in Mexico was recruited. Self-report structured questionnaires were used to assess sociodemographics, sexual behavior, and HPV protective behavior.

Findings:

Self-reported HPV knowledge among Mexican adolescents was low. Adolescents ( n = 81, 25.9%) self-reported sexual experience. Comparisons of adolescents by self-reported sexual experience identified significant differences, including higher condom use self-efficacy, sexual rights knowledge, a condom use action plan, and greater interpersonal influence on HPV protective behavior among those who had sexual experience. Significant factors predicting HPV protective behavior included self-reported number of sexual partners, condom use in past 3 months, and having a condom use action plan.

Conclusion:

An intervention targeting adolescents should encourage adolescents to develop their own cognitive processes, thereby facilitating the adoption or development of action plans for HPV protective behavior.
Assessing the Customer-Based Impact of Up-Selling Versus Down-Selling
Authors: Norvell Tim , Kumar Piyush , Contractor Sunil
Published: March 2018

This article evaluates customers’ postpurchase attitudinal and behavioral responses to two suggestive selling strategies employed in retail establishments: up-selling and down-selling. Our findings are based on a field study conducted among 2,381 customers from a large, national casual dining chain. We then followed up with 352 customers 1 month later to determine the impact of the suggestive selling strategy on future visitation. We find that while up-selling did improve short-term revenues, it had an adverse effect on customers’ attitudinal responses which resulted in a reduction in future brand patronage. Conversely, down-selling did not compromise short-term revenues as is commonly thought, and also led to a superior attitudinal response and increased brand patronage. We demonstrate that the effect of the suggestive selling strategy on satisfaction and brand loyalty is chain mediated through value and quality. Finally, our findings suggest that, under certain circumstances, employing a down-selling strategy may lead to superior long-term revenues.
Smart Refugees: How Syrian Asylum Migrants Use Social Media Information in Migration Decision-Making
Authors: Dekker Rianne , Engbersen Godfried , Klaver Jeanine , Vonk Hanna
Published: March 2018

Social media are increasingly popular channels of information on which migrants base their decisions on whether to migrate and the destinations where to settle. While social media offer a relatively cheap, easily accessible, and media-rich means of communication, their use is not without challenges for asylum migrants. Various studies describe issues with access and evaluation of the truthfulness of available information for this specific group of migrants. This article discusses social media use by asylum migrants prior to and during migration. This study is based on in-depth interviews with 54 Syrian asylum migrants who recently obtained refugee status in the Netherlands. Syrians were the largest group of migrants applying for asylum in European Union (EU) member states in 2015 and 2016. The findings show that the majority of Syrian asylum migrants have access to social media information before and during migration, often through the use of smartphones. Besides uneven access to technologies, fear of government surveillance restricts the smartphone use of asylum migrants. The results of this study indicate that Syrian asylum migrants prefer social media information that originates from existing social ties and information that is based on personal experiences. Generally, this information is considered more trustworthy. Asylum migrants use various strategies to validate rumors that are present on social media and come from unknown sources. These strategies include checking the source of information, validating information with trusted social ties, triangulation of online sources, and comparing information with their own experience.
A qualitative study of health professionals’ views on using iPads to facilitate distraction during paediatric burn dressing changes
Authors: Green Elizabeth , Cadogan Julia , Harcourt Diana
Published: March 2018

Introduction:

Distraction is a non-pharmacologic pain management technique commonly used to avert a person’s attention from procedural pain and distress during stressful procedures such as treatment after a burn injury. In recent years, computer tablets (such as iPads) have been used within paediatric burns services to facilitate distraction by way of apps, games, cartoons and videos during dressing changes. However, we know very little about health professionals’ experiences of using them in this context.

Methods:

The current study explored health professionals’ experiences of using iPads to facilitate distraction during paediatric burn dressing changes. Fifteen health professionals from a single paediatric burns unit were interviewed. Thematic analysis revealed two key themes: (1) the iPad is a universal panacea for distraction; and (2) trials and tribulations.

Discussion:

Participants considered iPads to be potentially useful and effective distraction tools, suitable for use with a wide range of patients with burn injuries including young children, adolescents and young adults. However, issues including health professionals’ understandings of one another’s roles, the challenge of working in a busy burns service, and lack of experience and confidence were identified as possible barriers to their use within routine burn care. Training for staff on the use of iPads as a means of facilitating distraction, development of guidelines and a review of how they are incorporated into routine burn care are recommended.
Enrichment in critical metals (In-Ge) and Te-Se in epithermal deposits of the ‘La Carolina’ district, San Luis, Argentina
Authors: Gallard-Esquivel M. C. , Cepedal A. , Fuertes-Fuente M. , Martin-Izard A.
Published: March 2018

Epithermal Au-Ag deposits of the La Carolina district, in the San Luis metallogenetic belt (Argentina), are related spatially and genetically to Mio-Pliocene volcanism. In this district, mineralization in the Cerro Mogote and Puesto La Estancia prospects occur as disseminations, veins and fracture/cavity infillings in volcanic/pyroclastic rocks, metamorphic basement and hydrothermal breccias. The gangue assemblage is dominated by carbonates (siderite, rhodochrosite, kutnahorite, dolomite). The main sulfides are pyrite, sphalerite, galena and chalcopyrite. Pyrite and sphalerite have compositional zoning, the former with As-rich cores and Cu-rich overgrowths, the latter with Fe-rich and Fe-poor bands. Sphalerite shows variable contents of Mn, Cu, In, Ga, Ge and Ag. The In-richest sphalerite hosts up to 5940 ppm In but also contains elevated concentrations of Cu, Ag, Ga and Ge, suggesting a coupled substitution mechanism resulting in enrichments in monovalent (Ag+, Cu+) and trivalent-tetravalent cations (Ga3+, In3+, Ge4+). The main precious metal minerals are Ag-rich tetrahedrite, acanthite, argyrodite, pearceite–polybasite and Au-Ag alloy. Locally, Se and/or Te-enriched minerals include galena Pb(S0.9–1Se0.1–0), hessite Ag2(Te0.9–1Se0.1–0), Se-rich cervelleite Ag4(Te1.3–0.9S1–0.5Se0.5–0.2), and also alburnite [Ag8GeTe2S4] and benleonardite [Ag15Cu(As,Sb)2S7Te4]. Pearceite contains Te (3.6–4.3 wt.%) and Se (1–2.3 wt.%) substituting for S, which are unusually high concentrations for this mineral. The Puesto La Estancia deposit contains various tellurides including sylvanite, petzite, stutzite, altaite, tellurobismuthite and volynskite. This study shows that the chemistry of the fluids fluctuated during ore deposition suggesting different fluid pulses (system rejuvenation and/or boiling). The enrichment in Te, Se and Bi enrichment is supportive of a magmatic contribution to the ore fluid, while graphite in the metamorphic basement could be the source of germanium, although a magmatic source cannot be ruled out.
Mental health and integration in Asia Pacific
Authors: Ng Chee H.
Published: March 2018

This brief report examines the extent to which community-based treatment and integration support are provided for people living with mental illness across 15 selected Asia-Pacific economies. Some of the key findings are discussed in light of the diversity of economies and cultural contexts.
The physiological regulation of macropinocytosis during Dictyostelium growth and development
Authors: Williams Thomas D. , Kay Robert R.
Published: March 2018

Macropinocytosis is a conserved endocytic process used by Dictyostelium amoebae for feeding on liquid medium. To further Dictyostelium as a model for macropinocytosis, we developed a high-throughput flow cytometry assay to measure macropinocytosis, and used it to identify inhibitors and investigate the physiological regulation of macropinocytosis. Dictyostelium has two feeding states: phagocytic and macropinocytic. When cells are switched from phagocytic growth on bacteria to liquid media, the rate of macropinocytosis slowly increases, due to increased size and frequency of macropinosomes. Upregulation is triggered by a minimal medium containing three amino acids plus glucose and likely depends on macropinocytosis itself. The presence of bacteria suppresses macropinocytosis while their product, folate, partially suppresses upregulation of macropinocytosis. Starvation, which initiates development, does not of itself suppress macropinocytosis: this can continue in isolated cells, but is shut down by a conditioned-medium factor or activation of PKA signalling. Thus macropinocytosis is a facultative ability of Dictyostelium cells, regulated by environmental conditions that are identified here.

This article has an associated First Person interview with the first author of the paper.
Balance between MAT2A intron detention and splicing is determined cotranscriptionally
Authors: Pendleton Kathryn E. , Park Sung-Kyun , Hunter Olga V. , Bresson Stefan M. , Conrad Nicholas K.
Published: March 2018

Transcriptome analysis of human cells has revealed that intron retention controls the expression of a large number of genes with diverse cellular functions. Detained introns (DI) constitute a subgroup of transcripts with retained introns that are not exported to the cytoplasm but instead remain in the nucleus. Previous studies reported that the splicing of DIs in the CLK1 transcript is post-transcriptionally induced to produce mature mRNA in the absence of new transcription. Thus, CLK1-DI serves as a precursor or “reservoir” for the CLK1 mRNA. However, whether this is a universal mechanism for gene regulation by intron detention remains unknown. The MAT2A gene encodes S-adenosylmethionine (SAM) synthetase and it contains a DI that is regulated in response to intracellular SAM levels. We used three independent assays to assess the precursor–product relationship between MAT2A-DI and MAT2A mRNA. In contrast to CLK1-DI, these data support a model in which the MAT2A-DI transcript is not a precursor to mRNA but is instead a “dead-end” RNA fated for nuclear decay. Additionally, we show that in SAM-deprived conditions the cotranscriptional splicing of MAT2A detained introns increases. We conclude that polyadenylated RNAs with DIs can have at least two distinct fates. They can serve as nuclear reservoirs of pre-mRNAs available for rapid induction by the cell, or they constitute dead-end RNAs that are degraded in the nucleus.
Association of delivery procedure with APGAR scores among neonates born to healthy Pakistani mothers: a pilot study
Authors: Khalid Muhammad Ali , Ghani Rida , Khalid Muhammad Fahad , Malik Muhammad Saad , Waqas Ahmed
Published: March 2018

Background: The present study explores the factors associated with poor APGAR scores among singletons born to healthy Pakistani mothers.

Methods: This cross-sectional study was conducted at a Tara Urea Medical Center, Iskandarabad Colony, district Mianwali, Pakistan from April 1 to August 30, 2017. Data was collected using a preformed proforma by a gynecologist and pediatrician during the birth procedure. The questionnaire comprised of two sections including neonatal and maternal characteristics. All data were analyzed in SPSS v.20.

Results: Regression analysis revealed that vaginal deliveries were associated with higher APGAR scores at five minutes than those delivered by cesarean section. However, maternal age and BMI and weight of the baby did not yield significant association with APGAR scores at five minutes. APGAR scores assessed at one minute were significantly associated with weight of the neonate.

Conclusion: APGAR scores of the neonates at birth are significantly associated with birth procedures. Therefore, birth procedure should be selected and managed effectively to reduce the risk of low APGAR scores.
Mitochondrial genomes of Anopheles arabiensis, An. gambiae and An. coluzzii show no clear species division
Authors: Hanemaaijer Mark J. , Houston Parker D. , Collier Travis C. , Norris Laura C. , Fofana Abdrahamane , Lanzaro Gregory C. , Cornel Anthony J. , Lee Yoosook
Published: March 2018

Here we report the complete mitochondrial sequences of 70 individual field collected mosquito specimens from throughout Sub-Saharan Africa. We generated this dataset to identify species specific markers for the followingAnophelesspecies and chromosomal forms:An. arabiensis,An. coluzzii(TheForestandMoptichromosomal forms) andAn. gambiae(TheBamakoandSavannahchromosomal forms).  The raw Illumina sequencing reads were mapped to the NC_002084 reference mitogenome sequence. A total of 783 single nucleotide polymorphisms (SNPs) were detected on the mitochondrial genome, of which 460 are singletons (58.7%). None of these SNPs are suitable as molecular markers to distinguish amongAn. arabiensis,An. coluzziiandAn. gambiaeor any of the chromosomal forms. The lack of species or chromosomal form specific markers is also reflected in the constructed phylogenetic tree, which shows no clear division among the operational taxonomic units considered here.
The advantages and disadvantages of encouraging consumerist notions of health care at two minor injury units
Authors: Sturgeon David
Published: March 2018

Over the past four decades, UK governments have moved towards an increasingly pro-market model of healthcare provision. Under this system, patients are not only encouraged, but expected, to take increasing responsibility for healthcare decision-making and the risks that it might entail. This article investigate how and why patients make choices about their health care and how service providers help facilitate this. Between October 2014 and May 2015, the researcher was embedded as an emergency nurse practitioner at two minor injury units in order to undertake direct and participant observation. During this time, 40 patients, 17 service providers and 1 senior manager also consented to semi-structured interview. The findings suggest that patients should continue to be encouraged to make decisions about their health care, but only if they feel confident to do so. The challenge for service providers is to recognise when this is or is not appropriate and tailor interaction accordingly.
Brief interventions to de-escalate disturbances in emergency departments
Authors: Edward Karen-leigh , Giandinoto Jo-Ann , Weiland Tracey J , Hutton Jennie , Reel Sarah
Published: March 2018

This study aimed to systematically review evidence to assess the efficacy of non-pharmacological brief interventions in the emergency department to reduce the incidence, severity and impact of acute behavioural disturbances. The literature search was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A total of 18 articles were identified as meeting the inclusion criteria and read in full. Following a full read and a consensus discussion, it was subsequently considered the studies chosen had not met the inclusion criteria. Research into the use of non-pharmacological brief interventions in the management of acute behavioural disturbance in the emergency department is warranted given the absence of evidence found by this systematic review.
An automatic repositioning system to prevent pressure ulcers: a case series
Authors: Knibbe Nico E , Zwaenepoel Elien , Knibbe Hanneke JJ , Beeckman Dimitri
Published: March 2018

The Danish automated Vendlet V5s repositioning system is intended to reduce pressure ulcer risk in patients and work-related musculoskeletal disorders (MSDs) in caregivers. In two Belgian nursing homes, 13 residents with mobility levels C, D and E experienced the repositioning system, operated by 35 caregivers, for 4 weeks. Data about skin condition, nursing time needed for repositioning and MSD symptoms were collected. The use of the repositioning system was not associated with the development of nor a reduction in skin problems; the study included residents who were vulnerable to or already had pressure ulcers. In addition, four pressure ulcers healed during the experiment. The research focused only on the automated repositioning system. Repositioning frequency and postures were determined by the standard nursing home protocol. Frequency depended on the support surface in use, and a limited number of patient criteria (mobility in bed, presence of bony prominences/pressure points and presence of non-blanchable erythema). In future studies, the Vendlet V5s system should be tested with a more individualised patient repositioning protocol, including more criteria such as fever and moisture. The automated system reduces nursing time so could potentially improve staff efficiency. Compared with manual repositioning, caregivers perceived fewer work-related MSD symptoms during repositioning when using the Vendlet V5s system. Controlled studies with larger samples are needed to verify these conclusions.
A clinical evaluation of a charcoal dressing to reduce malodour in wounds
Authors: Haynes Jackie Stephen
Published: March 2018

This article introduces the important issue of assessing and managing malodour. A literature review was undertaken and implications for practice identified in relation to CliniSorb. This paper presents an up-to-date 10-patient, single-site non-comparative clinical evaluation of CliniSorb using both quantitative and qualitative evidence from patients and clinicians. The data presented in this paper is used to discuss the embarrassing issue of malodour and highlights the importance for the clinician to consider this when planning patient care.
Who will you meet?
Authors: Williams Brenda
Published: March 2018

Use the action rhyme People We Know to help children to recognise diversity in people's occupations, while also connecting a range of job-roles to particular environments that they may be familiar with.
ANALISIS DAYA DUKUNG EKOLOGI UNTUK PENGEMBANGAN BUDIDAYA RUMPUT LAUT DI BAGIAN UTARA TELUK BONE
Authors: Arifin Taslim , Waluyo Waluyo
Published: March 2018

Abstract : Waters carrying capacity in seaweed (Eucheuma cottonii) cultures should be a concern for optimum seaweed culture. Carrying capacity can determine by ecological footprint (EF) analysis, which in this research use production footprint. This research on Mei 2015 (1sttransitionalseason) and September 2015 (2ndtransitionalseason) in Luwu and Palopo, South Sulawesi. Map and land use analyzed with  GIS (Geographic Information Systems).The results showed that theecological footprint production (EFP)in Luwu waters is 67.88 ton/capita/year, or equivalent to 235,823.93 tons/year.Based on the analysis of the availability of water for seaweed is 59,781.79 hectares, it can produce seaweed (biocapacity) for 1,437,779.60 tons/year and  the number of farmers that allows for use the waters is  21,432 capita. The ecological footprint  production (EFp) in Palopo waters is 3.08 ton/capita/year, or equivalent to 4,589.99 tons/year. Water availability analysis is 1,771.41 hectares are able to produce seaweed (biocapacity) for  18,287.46 ton/year and the number of farmers that allows for use the waters is 635 farmers capita. The results comparison between biocapacity and ecological footprint, ecological status for  Luwu and Palopo waters are still in sustainable use.
Opportunity Discovery and Creation as a Duality: Evidence from Small Firms’ Foreign Market Entries
Authors: Chetty Sylvie , Karami Masoud , Martín Oscar Martín
Published: March 2018

Little research addresses the likely enabling character of the discovery and creation of opportunities during the internationalization of small firms or how international opportunities are found and constructed during the process of foreign market entry (FME). This article therefore studies how opportunities become connected during small firms’ FME. By incorporating the concept of duality, this article conceives of the discovery and creation of opportunity as mutually enabling rather than opposed. From this duality perspective, opportunity discovery and creation facilitate each other during internationalization processes. This case study involves five high-tech Australian firms and 30 FMEs. The findings show that knowledge, networks, and capabilities enable opportunities in the FME context. International opportunities are connected and nested in different levels of generality and specificity. The FME opportunities may be based on opportunity embeddedness, because each opportunity has implications for other opportunities. The findings lead to a model and propositions to explain the relationships between opportunity discovery and creation in FME.
Articulation and Liars
Authors: Oms Sergi
Published: March 2018

Jamie Tappenden was one of the first authors to entertain the possibility of a common treatment for the Liar and the Sorites paradoxes. In order to deal with these two paradoxes he proposed using the Strong Kleene semantic scheme. This strategy left unexplained our tendency to regard as true certain sentences which, according to this semantic scheme, should lack truth value. Tappenden tried to solve this problem by using a new speech act, articulation. Unlike assertion, which implies truth, articulation only implies non-falsity. In this paper I argue that Tappenden’s strategy cannot be successfully applied to truth and the Liar.