bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Physicochemical, Sensory and Microbiological Quality of Raw Milk and Reconstituted Milk as Feedstock for Dairy Units in Dori, Burkina Faso
Authors: B. Sawadogo Joseph , S. Compaoré Clarisse , Boma Soudah , P. D. Taminy Dimitri , S. Traoré Alfred , Dianou Dayéri , Toguyeni Aboubacar
Published: March 2024

This study aimed to assess the physicochemical, sensory, and hygienic quality of milk destined for dairy processing units in Dori. Raw milk (n=10) derived from 10 farm-milking cows. Reconstituted milk (n=10) was powder milk added with water at 1/5, 1/7, 1/8, and 1/10 (kg/L), respectively. Physicochemical and microbiological parameters and sensory perception were analyzed. Results showed pH was unsuitable in raw milk (6.30) and reconstituted milk (6.28). The acidity (16.90°D), density (1.032), non-fat dry matter (9.34%), fat (3.91%), lactose (5.13%), and protein (3.42%) contents were by standards in 90-100% of raw milk against 7.5-20% of reconstituted milk. Raw milk was more satisfactory sensory quality than reconstituted milk. However, 90-100% of raw milk was poor sanitary quality regarding total aerobic mesophilic flora, negative-coagulase staphylococci, yeasts and molds (4.35x106, 1.12x106 and 1.48x103 CFU/mL, respectively), whereas 70-100% was acceptable quality to total and fecal coliforms (1.25x103and 6.84x102 CFU/mL, respectively). Conversely, 100% of reconstituted milk was poor quality regarding total and fecal coliforms (3.88x104, 4.39x103 CFU/g, respectively). These analyses highlight potentially hazardous products that can pose a serious public health risk and spoil the quality of end-products of dairy units if the milk is not adequately processed and highly adulterated by adding water.
Molecular Characterization of Azotobacter and PSB from Xerophytic Plants of Maharashtra State, India
Authors: Barge Monika Suresh , Narute T. K.
Published: March 2024

The present study was conducted at Department of Plant Pathology and Agricultural Microbiology, MPKV, Rahuri during year 2021 to 2023 to characterize and screen different isolates of Azotobacter and PSB from Different Xerophytic plants from Different districts of Maharashtra State. 68 Azotobacter isolates were biochemically characterized and screened under In vitro conditions for their plant growth promoting properties. This isolates were biochemically characterized and screened In-vitro condition for their plant growth promoting properties. DNA polymorphism of isolates was studied using randomly amplified polymorphic DNA analysis. The genetic diversity among the bacterial strains was assessed by RAPD analysis. All the isolates showed reproducible DNA banding pattern. Diversity among the bacterial strains was assessed on the basis of variation of size number and intensity of bands.
A Case Study of Uncommon Klebsiella Species Infection with Lymphadenopathy
Authors: Shukla Manisha , Purohit Sandeep , Vishwakarma Rohit Kumar , Anjum Shireen , Lakhotia Harsha , Vishwakarma Riya
Published: March 2024

Klebsiella pneumoniae is a Gram-negative bacterium known for causing a range of infections, particularly in immunocompromised and hospitalized individuals. However, community-acquired cases, especially in young, healthy individuals, are rare. We present a case study of a 23-year-old female patient with severe Klebsiella pneumonia, has been experiencing recurrent and persistent fever, shortness of breath, weakness, pain in legs and anorexia for the past 3 months and was suspected of having an eating disorder and vomiting. Based on physical, biochemical, CT scan and blood culture, the patient was diagnosed Klebsiella infection. Abdomen sonography report reveals mild Hepatosplenomegaly with liver mildly enlarged and spleen mildly enlarged. The patient was admitted to the hospital and initiated on intravenous antibiotics (Ciprofloxacin and Doxycycline) and fever management. The patient responded well to treatment, with resolution of fever and respiratory distress. After discharge, the patient was advised to follow up for further evaluation. But after a week, she was again affected by fever and diagnosed with lymphadenopathy. Timely diagnosis, appropriate antibiotic therapy, and supportive care can lead to favourable outcomes.
A Genomic Approach to Understand Plants - The Pandora Box yet to be Explored
Authors: Johny Aleena
Published: March 2024

The recent advances in plant sciences, in combination with bioinformatics and analogous development in tools, software and visualisation modelling, have steered the scientific community to an aggressive argumentation of information. Even after the emergence of Omics and several such splendid bioinformatics tools, a substantial number of researchers need to become more familiar with these tools. This review focuses on the applications of various in silico tools and technologies that may be adopted to analyse the plant sciences. The understanding of these different technologies shall lead us to a better understanding of plant properties such as stress tolerance, pathogenic resistance nutritional improvement. We are also converging thoughts on different trials and constraints in plant sciences in connection with the bioinformatics approach.
Band Pattern Analysis of the rpoB, inhA, and katG Gene in Mycobacterium tuberculosis through Line Probe Assay in Patients from Western Rajasthan, India
Authors: Chouhan Mahima , Parihar R. S.
Published: March 2024

Tuberculosis is globally a leading cause of death with increasing rates of drug resistance which has become a serious topic of concern. Early diagnosis and properly administered treatment regimen are the key elements to combat Tuberculosis and its transmission. Rapid molecular methods have been recommended for early detection of drug resistant Tuberculosis. This study aimed to analyze the mutation band pattern in rpoB, inhA, katG gene of drug resistant pulmonary tuberculosis through Hybridization technique using Genotype MTBDR plus V.2 assay in Western Rajasthan. Positive sputum samples were collected from MDR/ Mono DR Patients. Sputum decontamination was performed after the quality assurance then DNA extraction, amplification, hybridization and band pattern analysis of line probe assay strips was performed as per manufacturer’s instructions by GenoType MTBDRplus kit from Hain Lifescience. Out of 215 study participants, 174 (80.9%) were male and 41 (19%) were female, with a mean age group of 41 years, where (146/215; 67.9%) were rural dwellers. 56.2% of the population was sensitive to both the drug (Rifampicin and Isoniazid). Of the 215 isolates, 12 (5.58%) were hetero-resistant to both RIF and INH i.e. the overall proportion of MDR-TB was 12 (5.58%) There were 6 isolates (2.79%) mono-resistant to RIF and 16 isolates (7.44%) mono-resistant to INH. In rpoB gene, WT 7 (2%) and WT 8 (7.2%) band were the most common band to be absent. In katG gene, MUT 1 band showed maximum mutation (14.9%). In inhA gene, WT 1 band was most common band to be absent (4.6%) and MUT 1 band showed 2.5% of mutation. In the present study analysis of MUT 2 band of rpoB, katG and inhA genes did not show any presence. High frequencies of mutations in rpoB, inhA, and katG gene by LPA were observed. The most common resistance-conferring mutations to RIF occurred at rpoB gene with absence of band WT8 and presence of MUT3 band. In katG gene absence of WT1 and presence of MUT1 band was most common pattern of mutation and in inhA gene, WT1 band was prominently absent.
Keeksotisan Motif Bunga Bangkai Amorphophallus Titanum pada Produk Fashion Pria Ready To Wear
Authors: Sugianto Riki , Oetopo Ataswarin
Published: March 2024

Merancang desain permukaan kain dengan motif Bunga Bangkai Amorphophallus Titanummerupakan cara yang unik untuk memperkenalkan jenis bunga langka ini. Oleh karena itu, perupa mengambil tugas akhir ini dengan judul “Keeksotisan Motif Bunga Bangkai Amotphophallus Titanum pada Produk Fashion Pria Ready To Wear”. Tujuan penelitian ini adalah meningkatkan kemampuan perupa dalam pembuatan karya dan mengembangkan ide dalam menciptakan berbagai desain motif kain. Proses eksplorasi yang panjang menghasilkan berbagai macam rancangan motif, pola, pengulangan, hingga model busana. Metode penelitian dalam penciptaan karya seni rupa ini menggunakan metode kualitatif, dengan teknik pengumpulan data, observasi, wawancara, dan dokumentasi secara actual hasil dari penelitian di lapangan serta hasil eksplorasi terhadap motif Bunga Bangkai Raksasa serta jenis kain yang berbeda. Melalui proses analisis konseptual, visual, dan operasional terpilih 6 karya kemeja pria dengan 6 desain yang berbeda serta Bunga Bangkai Raksasa sebagai motif utamanya. Kesimpulan dari penciptaan karya seni rupa ini yaitu proses pengaplikasian motif pada kain secara digital merupakan cara paling efisien karena penggunaan tinta warna sesuai kebutuhan desain sehingga ramah lingkungan. Penciptaan karya ini bisa menjadi peluang bisnis bagi perupa dan peluang lapangan pekerjaan baru bagi masyarakat Indonesia.
Picture Book Visualisasi Multikulturalisme Untuk Anak Usia 7-9 Tahun
Authors: Zahra Aisyia , Mudjiati
Published: March 2024

Penciptaan karya seni rupa ini berfokus pada penanaman multikultural melalui picture book yang bertemakan kesatuan dalam keberagaman. Tujuan penelitian ini yaitu sebagai komunikator bagi anak-anak akan pentingnya memiliki sikap toleransi di tengah realita multikultural negara Indonesia. Penelitian ini berlandaskan teori multikultural yang mencakup ras, suku bangsa, agama, konflik dan solusi multikultural, ilustrasi, elemen artistik, elemen desain, dan teori perkembangan anak tahap skematik (7-9 tahun). Anak pada tahap tersebut telah memiliki kesadaran dan empati yang mulai berkembang terhadap lingkungannya, sehingga cocok untuk diberi pengetahuan terhadap toleransi keberagaman budaya. Metode pengumpulan data yang digunakan adalah metode kualitatif. Pengumpulan data dilakukan dengan observasi tren produk sejenis, melakukan studi teori, mengumpulkan referensi gaya ilustrasi dan karakter. Berbagai eksplorasi dilakukan antara lain eksplorasi karakter utama, karakter pendukung, layout, serta cover (sampul). Setelah proses tersebut dilanjutkan dengan membuat storyboard, membuat sketsa, dan pemberian line-art dengan teknik manual. Pewarnaan hingga tahap penyusunan layout dilakukan dengan teknik digital. Eksplorasi keunikan dan keberagaman bangsa Indonesia tersebut dapat mengembangkan kompetensi berkarya. Pendidikan multikultural disampaikan melalui picture book berupa cerita dan ilustrasi yang menarik. Karya picture book berupa dua buku seri dengan judul Melukis Persahabatan dan Liem Tidak Sendiri diharapkan dapat memberi makna persahabatan dan toleransi di lingkungan anak.
Ruang Bermain Futuristik Bagi Anak
Authors: Febriyani Wiwit , Kherid Zaitun Y.A , Mudjiati
Published: March 2024

Seiring zaman, anak cenderung menyukai bermain gadget dibanding bermain dengan teman sebayanya. Dari hasil survei “The Asianparent Insight 2014” lingkup Asia Tenggara, anak usia 6-9 tahun lebih tertarik bermain gadget baik disela-sela belajar maupun setelah selesai belajar. Berdasarkan hal tersebut, maka perupa menciptakan karya berupa ruang bermain dengan permainan yang bisa dimainkan dua orang atau lebih secara langsung. Metode penelitian ini menggunakan metode kualitatif. Jenis riset penelitian dan penciptaan ini menggunakan practice-led research, yaitu penelitian menjadi dasar dalam praktik. Sumber data dalam penelitian ini diperoleh dari berbagai narasumber, sumber tertulis dan foto guna memperoleh data yang diperlukan. Teknik pengumpulan data melalui observasi, wawancara, kuesioner, studi pustaka, dan pendokumentasian. Ruang bermain bertema Antariksa untuk anak usia 6-11 tahun berukuran 3x3 m dengan permainan yang bisa dimainkan dua orang atau lebih secara langsung, seperti permainan ular tangga bahan kain taslan, flash card  ukuran A5 dengan bahan glossy photo paper, puzzle ukuran 20x30 cm bahan karton tebal dilapisi bahan glossy, bean bag ukuran 75cmx120cm bahan baby canvas, dan knowladge classification box  ukuran 30x11 cm berbahan kayu dan setiker. Desain karakter digunakan bukan hanya manusia tapi juga hewan,  desain karakter hewan dikaitkan dengan hewan yang dikirm keluar angkasa berdasarkan beberapa sumber literature. Dari hasil mengambil data secara langsung, anak-anak sangat tertarik dengan dunia Antariksa.
Pembelajaran Menggambar Dengan Teknik Digital Pada Beginner Class di Ageru Art Studio
Authors: Anggraeni Enggar Banifa
Published: March 2024

Di era modern ini menggambar tidak hanya dapat dilakukan secara tradisional seperti menggunakan kertas dan pensil, tapi juga dapat dilakukan dengan cara digital. Salah satu tempat yang memberikan pelatihan menggambar dengan teknik digital sebagai bentuk pendidikan non formal yaitu Ageru Art Studio. Terdapat kelas pemula yang disediakan oleh mereka atau disebut dengan Begginer Class. Tujuan penelitian ini adalah untuk mendeskripsikan konsep pembelajaran pada Ageru Art Studio sebagai tempat pelatihan menggambar dengan teknik digital, khususnya di Beginner Class. Metode penelitian menggunakan kualitatif dengan pendekatan partisipatoris. Dalam hal ini, peneliti mengamati dan terlibat langsung dalam proses pembelajaran. Hasil penelitian menemukan bahwa konsep operasional pembelajaran dikendalikan langsung oleh manajer operasional dan interaksi secara langsung kepada tutor terkait proses pembelajaran. Untuk proses pembelajarannya, beginner class terbagi menjadi dua, diantaranya Basic Class dan Basic Manga Kids. Pada Basic Class, murid yang masih berada dibangku sekolah dasar akan mempelajari cara menggambar dengan pentablet dan mewarnai. Sedangkan Basic Manga Kids, murid akan diajarkan cara membuat gambar manga. Kendala yang ditemukan pada yaitu kurangnya tenaga tutor dan murid yang cukup banyak terkadang membuat kelas kurang kondusif.
AVIAN FORAGING ON AN INTERTIDAL MUDFLAT SUCCESSION IN THE EOCENE TANJUNG FORMATION, ASEM ASEM BASIN, SOUTH KALIMANTAN, INDONESIAN BORNEO
Authors: ZONNEVELD J.-P. , ZAIM Y. , RIZAL Y. , ASWAN A. , CIOCHON R.L. , SMITH T. , HEAD J. , WILF P. , BLOCH J.I.
Published: March 2024

Moderately diverse trace fossil assemblages occur in the Eocene Tambak Member of the Tanjung Formation, in the Asem Asem Basin on the southern coast of South Kalimantan. These assemblages are fundamental for establishing depositional models and paleoecological reconstructions for southern Kalimantan during the Eocene and contribute substantially to the otherwise poorly documented fossil record of birds in Island Southeast Asia. Extensive forest cover has precluded previous ichnological analyses in the study area. The traces discussed herein were discovered in newly exposed outcrops in the basal part of the Wahana Baratama coal mine, on the Kalimantan coast of the Java Sea.

The Tambak assemblage includes both vertebrate and invertebrate trace fossils. Invertebrate traces observed in this study include Arenicolites, Cylindrichnus, Diplocraterion, Palaeophycus, Planolites, Psilonichnus, Siphonichnus, Skolithos, Thalassinoides, Taenidium, and Trichichnus. Vertebrate-derived trace fossils include nine avian footprint ichnogenera (Aquatilavipes, Archaeornithipus, Ardeipeda, Aviadactyla, cf. Avipeda, cf. Fuscinapeda, cf. Ludicharadripodiscus, and two unnamed forms). A variety of shallow, circular to cylindrical pits and horizontal, singular to paired horizontal grooves preserved in concave epirelief are interpreted as avian feeding and foraging traces. These traces likely represent the activities of small to medium-sized shorebirds and waterbirds like those of living sandpipers, plovers, cranes, egrets, and herons. The pits and grooves are interpreted as foraging traces and occur interspersed with both avian trackways and invertebrate traces.

The trace fossils occur preferentially in heterolithic successions with lenticular to flaser bedding, herringbone ripple stratification, and common reactivation surfaces, indicating that the study interval was deposited in a tidally influenced setting. Avian trackways, desiccation cracks, and common rooting indicate that the succession was prone to both subaqueous inundation and periodic subaerial exposure. We infer that the Tambak mixed vertebrate-invertebrate trace fossil association occurred on channel-margin intertidal flats in a tide-influenced estuarine setting. The occurrence of a moderately diverse avian footprint and foraging trace assemblage in the Tambak Member of the Tanjung Formation illustrates that shorebirds and waterbirds have been using wetlands in what is now Kalimantan for their food resources since at least the late Eocene.
ANALISA PEMICU TERJADINYA AKTIVITAS IMPOR DAN EKSPOR ILEGAL YANG BERDAMPAK PADA STABILITAS KEUANGAN NEGARA
Authors: Rahmadani Karunia Fitri
Published: March 2024

Aktivitas impor dan ekspor ilegal di Indonesia menjadi perkara yang sudah sangat berurat dan berakar, dimana perkara tersebut masuk ke dalam kawasan kepabeanan. Di Indonesia, dari segi yuridis, kepabeanan sendiri telah memiliki payung hukumnya yaitu Undang-Undang Nomor 10 Tahun 1995 sebagaimana telah diubah dengan Undang-Undang Nomor 17 Tahun 2006 tentang Kepabeanan. Dalam praktiknya, pelaksanaan kepabeanan tersebut diawasi oleh JDBC. Akan tetapi meski secara yuridis telah memiliki aturan, hal tersebut tidak memberi jaminan akan terhindarnya negara dari adanya tindak pidana penyelundupan. Hal tersebut dikarenakan, selain pada penegak hukumnya, dari segi yuridisnya, masih ada beberapa pasal yang masih multitafsir hingga memicu terjadinya aktivitas impor dan ekspor ilegal tersebut. Metode penelitian yang digunakan dalam penelitian adalah yuridis normatif, dimana penelitian dilakukan dengan cara menemukan kebenaran berdasarkan logika keilmuan hukum dari segi normatifnya. Aktivitas impor dan ekspor ilegal sendiri sangat berdampak pada stabilitas keuangan negara, mengingat sektor pabean cukup banyak menyumbangkan pendapatan bagi negara. Meski UU Kepabeanan telah memberikan landasan hukum akan kepabeanan, namun masih ada pasal-pasal yang multitafsir hingga memicu pelaku untuk melakukan tindak pidana penyelundupan tersebut.
KONSEPSI PENGATURAN PERPAJAKAN DI INDONESIA BERBASIS PEMULIHAN EKONOMI
Authors: Saputra Rizky
Published: March 2024

Pandemi covid-19 telah berdampak besar pada lahirnya krisis keuangan di berbagai negara termasuk Indonesia. Di antara faktor yang mengakibatkan kontraksi tersebut yakni berkurangnya penerimaan negara terlebih dari sektor perpajakan. Maraknya pemutusan hubungan kerja, penurunan omzet usaha masyarakat, hingga keterpurukan finansial di semua lini akibat pembatasan sosial selama pandemi ini menjadi sebab pokok rendahnya penerimaan negara dari sektor perpajakan. Salah satu langkah besar yang dilakukan Pemerintah dalam mengurai masalah ini adalah mengeluarkan kebijakan berupa Undang-Undang Nomor 7 Tahun 2021 tentang Harmonisasi Peraturan Perpajakan. Akan tetapi, langkah tersebut dinilai justru menimbulkan berbagai permasalahan hukum. Beberapa di antaranya adalah ketidakpastian hukum serta ketidaksetaraan (inequality) yang berpotensi melahirkan ketimpangan di tengah masyarakat yang tengah terpuruk akibat pandemi ini. Oleh sebab itu, konsepsi peraturan perpajakan di Indonesia yang dibuat dalam rangka pemulihan ekonomi akibat pandemi covid-19 penulis rasa mutlak perlu dilakukan. Melalui penelitian hukum normatif, disimpulkan bahwa ke depan peraturan perpajakan harus disusun ulang dengan mempertimbangkan problem-problem hukum dan realitas yang ada di masyarakat serta tidak bertentangan dengan amanah yang termaktub dalam konstitusi.
PROBLEMATIKA YURIDIS PENERBITAN SURAT PERINTAH SEBELAS MARET DALAM SISTEM KETATANEGARAAN INDONESIA
Authors: Mahardika Ahmad Gelora
Published: March 2024

Surat Perintah Sebelas Maret merupakan salah satu sejarah ketatanegaraan yang masih menyimpan permasalahan. Hal itu disebabkan Supersemar kerap kali dilihat semata-mata sebagai peristiwa politik yang menandai berakhirnya orde lama dan masuknya orde baru. Padahal, Supersemar sepatutnya harus dinilai secara objektif sebagai produk hukum yang diterbitkan oleh Presiden sebagai Kepala Negara dalam sistem ketatanegaraan Indonesia. Hal itu disebabkan, sistem ketatanegaraan Indonesia pada era tersebut mempunyai perbedaan yang signifikan dengan kondisi ketatanegaraan era reformasi. Mengkaji fenomena Supersemar sebagai bagian dari sejarah ketatanegaraan akan membawa peneliti untuk memastikan tidak terjadi lagi kecelakaan sejarah yang serupa. Pertanyaan penelitian dalam artikel ini adalah bagaimanakan problematika yuridis penerbitan surat perintah sebelas Maret dalam sistem ketatanegaraan Indonesia. Metode penelitian yang digunakan dalam artikel ini adalah yuridis normatif. Hipotesis yang ditemukan adalah Supersemar secara formil ataupun  materiil  tidak terdapat persoalan, akan tetapi terjadi penyimpangan dalam implementasinya.
DISHARMONI PEMBATASAN HAK POLITIK MANTAN TERPIDANA MENJADI CALON ANGGOTA LEGISLATIF PEMILIHAN UMUM 2024
Authors: Munawwir Yusron
Published: March 2024

Penelitian ini bertujuan untuk mengetahui disharmoni pembatasan hak politik mantan terpidana menjadi calon anggota legislatif Pemilihan Umum 2024 dan untuk mengetahui akar permasalahannya. Metode penelitian ini merupakan penelitian hukum normatif dengan pendekatan perundang-undangan dan teoretis, yang mengkaji data sekunder berupa peraturan perundang-undangan dan teori terkait. Hasil penelitian menunjukkan bahwa Peraturan Komisi Pemilihan Umum Nomor 10 Tahun 2023 Pasal 11 ayat (6) dan Peraturan Komisi Pemilihan Umum Nomor 11 Tahun 2023 Pasal 18 ayat (2) bertentangan dengan amar putusan Mahkamah Konstitusi Nomor 12/PUU-XXI/2023 dan Putusan Nomor 87/PUU-XX/2022. Peraturan Komisi Pemilihan Umum tersebut tidak memberlakukan syarat bagi mantan terpidana melewati jangka waktu 5 (lima) tahun setelah selesai menjalani pidana penjara, jika ditentukan lain oleh putusan pengadilan yang telah memperoleh kekuatan hukum tetap untuk pidana tambahan  pencabutan hak politik. Komisi Pemilihan Umum mengatur ketentuan tersebut atas dasar pertimbangan Mahkamah yang sifatnya hanya penjelasan dan tidak menjadi dasar atau alasan yang menentukan amar putusan (obiter dictum), sehingga memunculkan norma hukum baru yang justru bertentangan dengan amar putusan Mahkamah Konstitusi.
Repeated use of hybrid isolated chemoperfusion with melphalan in non-resectable liver malignancy
Authors: Babich A. I. , Privalov M. A. , Demko A. E. , Reva V. A. , Manukovskiy V. A. , Cheremisov V. V. , Reshetov I. V.
Published: March 2024

Background. The incidence of liver malignancies is increasing, radical surgery can be performed in a small number of patients, most of them receive drug treatment. Isolated liver chemoperfusion (ILP) is a method of regional chemotherapy that is effective for some metastases but has a high complexity and frequency of complications. An improved method of hybrid ILP may offer new opportunities for patients with unresectable liver tumors. Case report. A 64-year-old patient diagnosed with stage IV sigmoid colon cancer underwent hybrid ILP. The patient was discharged after 6 days in a satisfactory condition without complications. Systemic chemotherapy was performed 21 days after the first hybrid chemoperfusion. The second hybrid chemoperfusion procedure was performed without the laparotomy stage, mobilizing the right common femoral vein and artery. As a result of the chemotherapy, the patients received a positive result on the mRECIST scale – a complete tumor response. Conclusion. The developed method of hybrid ILP has several advantages over traditional ILP and chemosaturation with infusion into the hepatic artery. This method can also be performed repeatedly, which is not possible with traditional ILP.
Analysis of the impact of cytoreductive surgery in patients with oligometastatic renal cell carcinoma in clinical practice
Authors: Semenov D. V. , Orlova R. V. , Shirokorad V. I. , Kostritsky S. V. , Gluzman M. I. , Korneva Yu. S.
Published: March 2024

Cytoreductive nephrectomy (CN) and metastasectomy are justified in patients with oligometastatic renal cell carcinoma (RCC). Objective: to evaluate the impact of cytoreductive surgery on survival rates in patients with oligometastatic RCС. Material and Methods. We retrospectively analyzed the data of 342 patients with oligometastatic RCC, who underwent systemic therapy and different types of cytoreductive surgeries at the Municipal Oncology Hospital No. 62 in Moscow and the Municipal Oncoloy Center in Saint Petersburg from 2006 to 2022. Cytoreductive nephrectomy was performed in 332 (97.1 %) patients, metastasectomy in 103 (30.1 %) patients. The survival rates of patients in treatment groups were evaluated using the Survival Analysis by calculating descriptive characteristics of survival time by means of a life-table and Kaplan–Meier curves. The results were considered statistically significant at p<0.05. Results. In the univariate analysis, in patients who underwent CN, the factors that had a negative effect on the prognosis of survival rates were the tumor grade, evidence of bone metastases, levels of ALP, LdH, ESR, as well as prognosis according to the IMdC model and metastasectomy. In the multivariate analysis, only IMdC prognosis was found to have a negative effect on survival rates. In both the univariate and multivariate analysis, in the group of patients who underwent metastasectomy, IMdC prognosis alone had an unfavorable impact on survival rates of patients with oligometastatic RCC. Conclusion. Our study showed that CN and metastasectomy had a statistically significant effect on OS (p=0.02 and p=0.032) of patients with oligometastatic RCC. division of the patients into prognosis groups according to the IMdC model showed that CN did not improve the OS rates in patients with oligometastatic RCC with intermediate and unfavorable prognosis, and metastasectomy significantly increased the OS rates in oligometastatic RCC patients with favorable and unfavorable prognosis (p=0.0055 and p=0.047). When evaluating prognostic factors in patients undergoing CN and metastasectomy, only IMdC prognosis had an impact on the OS rates (p<0.001).
Preoperative level of sex hormones as a predictor (prognostic factor) of the morphological characteristics of testicular malignancies
Authors: Kholbobozoda R. F. , Kostin A. A. , Vorobyev N. V. , Tolkachev A. O. , Krasheninnikov A. A. , Taraki I. A. , Kaprin A. D.
Published: March 2024

Introduction. Testicular cancer (TC) mostly affect young men of reproductive age. Several studies have shown correlation between the level of sex hormones in testicular cancer and serum tumor markers. However, currently, the relationship between hormone levels before orchidectomy and the clinical and pathomorphological characteristics of the tumor has not been sufficiently studied. Aim of the study: to analyze the relationship between hormone levels and the clinical stage and histological characteristics of the tumor in patients with testicular cancer and to develop prognostic models. Material and Methods. This prospective single-center study included 66 patients with testicular cancer. Localized, locally advanced and metastatic testicular cancer was diagnosed in 55 (83.3 %), 9 (13.6 %) and 2 (3.0 %) patients, respectively. A preoperative assessment of hormones such as total and free testosterone (T), estradiol (E2)), gonadotropic hormones (LH, FLH, Prolactin) and b-HCG was carried out. Patients were divided into 2 groups depending on the histological structure of the tumor: seminoma (n=31) and non-seminoma (n=35). The following parameters were assessed: tumor size, lymphovascular invasion and rete testis invasion. Results. In non-seminoma tumors, the values of sex hormones and beta-hCG were higher, but the values of gonadotropic hormones were lower compared with typical seminomas (p<0.05). High concentrations of b-HCG were observed predominantly in pT3 compared to pT1 stages (p=0.018). Correlation analysis revealed a connection between total (ρ=0.351; p=0.004) and free T (ρ=0.342; p=0.008), E2 (ρ=0.292; p=0.022), b-HCG (ρ=0.244; p= 0.048), LH (ρ=-0.287; p=0.039), FSH (ρ=-0.264; p=0.04) and the size of the primary tumor. The presence of rete testis invasion was accompanied by a low LH value and a high b-HCG value compared to patients without this prognostic parameter (p=0.015, p<0.001, respectively). Prognostic models were developed to determine the probability of histological structure and the presence of rete testis invasion (p<0.001) with high sensitivity (82.1 % and 76.5 %) and specificity (76.9 % and 100 %). Conclusion. The findings suggest that non-seminoma tumors are associated with changes in the pituitary-gonadal (HPG) axis. The high values of sex hormones and low values of gonadotropic hormones before orchidectomy are associated with a large size of the primary tumor. Additionally, a low LH value and a high b-HCG value are predictors of rete testis invasion. High b-HCG levels are associated with more aggressive tumor biology and poor prognosis.
miR-155 and miR-223 as markers of biological and clinical features of chronic lymphocytic leukemia
Authors: Perepechaeva M. L. , Goreva O. B. , Berezina O. V. , Pospelova T. I. , Grishanova A. Yu.
Published: March 2024

Introduction. Chronic lymphocytic leukemia (CLL) is a disease characterized by large individual differences both in the clinical course and in molecular patterns of expression of genes and regulatory RNAs, which can influence pathological changes. The involvement of regulatory microRNAs miR-155 and miR-223 in the pathogenesis of CLL is fairly well known, but there is insufficient information about possible fluctuations in the expression of miR-155 and miR-223 depending on the time course of pathology development and on parameters of medical treatment. Purpose – to investigate the expression of miR-155 and miR-223 in patients having CLL with different biological and clinical features and different characteristics of treatment in terms of peripheral-blood substrates (plasma, lymphocytes, and extracellular vesicles) and bone marrow. Material and Methods. This work involved samples of peripheral blood and bone marrow from 38 patients with a diagnosis of CLL from the City Hematology Center at the government-funded healthcare institution (Novosibirsk Oblast) City Clinical Hospital No. 2 from the years 2016 to 2017. Assessment of miR-155 and miR-223 expressions was carried out by reverse-transcription real-time PCR according to the TaqMan principle. Significance of differences between groups was evaluated either by the nonparametric Mann–Whitney test or by the nonparametric Kruskal–Wallis test with subsequent pairwise comparisons via the Mann–Whitney test. Results. High variation of the analyzed parameters was found. The expression levels of miR-155 and miR-223 in microvesicles of patients with unfavorable chromosomal anomalies were lower than those in patients with the chromosomal aberrations (or the normal karyotype) associated with a moderate effect on CLL prognosis. The expression level of miR-223 in peripheral blood lymphocytes of untreated patients with CLL was higher than that observed in treated patients. Conclusion. differences in the expression levels of miR-155 and miR-223 were identified depending on chromosomal aberrations and polychemotherapy. Our preliminary results will provide the basis for future larger studies on levels of microRNAs in CLL patients having specific features of the development, clinical course, and treatment of the disease.
Acute Lung Injury Associated with Blood Transfusion in a Hysterectomy Patient: A Case Report
Authors: Bielinskyi Mykyta , Halandzhii Marian-Andrii , Dashchenko Yurii , Chaplynska Nataliia
Published: March 2024

This case report presents a case of transfusion-related acute lung injury (TRALI) in a 50-year-old female patient who underwent total hysterectomy due to multiple fibromyomas. The patient developed dyspnea, heart palpitations, and fatigue postoperatively, with SpO2 dropping to 61%. Despite initially suspecting pulmonary embolism, the normal D-dimer level and characteristic changes observed on X-ray facilitated the diagnosis of TRALI. The patient was successfully treated with oxygen supplementation, intravenous corticosteroids, and thromboembolism prophylaxis, resulting in complete recovery. This case underscores the importance of considering TRALI in the differential diagnosis when patients exhibit respiratory distress following transfusion.
Actividad probiótica de PROBIOLACTIL®, SUBTILPROBIO® y su mezcla en pollos de ceba
Authors: Rondón-Castillo Ana Julia , Betancur‐Hurtado César A. , Rodríguez-Oliva Marlen , Beruvides-Rodríguez Agustín , Milián-Florido Grethel
Published: March 2024

Biopreparations with Lactobacillus salivarius and Bacillus subtilis are used as probiotics in poultry farming due to their beneficial effects on the intestinal ecosystem. Objective. To evaluate the probiotic activity of the biopreparations PROBIOLACTIL®, SUBTILPROBIO® and their mixture on microbiological, productive and health indicators in broilers. Materials and methods. An experiment with a completely randomized design was carried out for 42 days with four treatments: T1. Control diet (control group), T2. PROBIOLACTIL® (bioprepared with Lactobacillus salivarius C-65) + diet, T3. SUBTILPROBIO® (Bioprepared with Bacillus subtilis E-44) + diet and T4. Mixture of both biopreparations + diet. Results. The treatments where the probiotics were applied presented an increase in total lactobacilli and anaerobes (p≤0.05) and a reduction in total coliforms. Live weight was higher in birds treated with the mixture, and weight gain, average daily gain, feed conversion and carcass yield were improved. The application of additives reduced mortality and increased viability in birds. Conclusions. The synergistic activity of Lactobacillus salivarius and Bacillus subtilis increases probiotic activity and favors the productive performance and viability of broilers.
El estrés calórico afecta a las hembras ovinas Blackbelly durante el verano en el trópico
Authors: García y González Ethel Caterina , Pineda-Burgos Blanca Celia , Ruiz-Ortega Maricela , Cortez-Romero Cesar , Paredes-Alvarado Marisol , Ponce-Covarrubias José Luis
Published: March 2024

Objective. To determine whether Blackbelly ewes are affected by heat stress (HS) during the summer in a tropical climate. Materials and methods. In this experiment, 21 female ewes were divided into two treatments (T1=7 female lambs and T2=14 multiparous ewes) to evaluate the effect of HS through the temperature and humidity index (THI), physiological, and hematological variables. Results. In the experiment, a THI between 77 and 88 U was found. Likewise, respiratory rate (RR) was higher in T2 in the afternoon (117 bpm) than in the morning (114 bpm) (p<0.05). Also, rectal temperature (RT) was found to be higher in T1 in the afternoon (39.3°C) than in the morning (38.9°C) (p<0.05). Finally, it was found that the heart rate (HR) was higher at T2 during the afternoon (p<0.05). The hematocrit (HCT) and hemoglobin (HB) variables were similar between treatments during the study, but there were differences between samples two to seven (higher concentrations) compared to sample 13 (lowest concentration) (p<0.001). Finally, the potential of the Hydrogen variable (pH) showed variations, being higher in samplings three and six, and lowest values in samples four, five, seven, and twelve (p<0.001). Conclusions. Blackbelly ewes showed severe HS during the summer in the tropics of Guerrero.
Effects of temperature and live prey concentration on Colossoma macropomum larviculture
Authors: Costa dos Santos Fabio Aremil , Soares da Costa Julio Gustavo , De Sena Souza André , Cortezzi Pedras Pedro Paulo , Kennedy-Luz Ronald
Published: March 2024

Objective. The study evaluated the performance and survival of Colossoma macropomum larvae at different temperatures and concentrations of prey. Materials and methods. Two temperatures (28 and 32ºC) (T) and two initial daily concentrations (500 and 1,000 Artemia nauplii per larva) (CP) of prey were used. These concentrations were increased every 5 days during the first 15 days of cultivation. From the 16th to the 30th day, the larvae received exclusively a commercial diet. Results. In the first 7 days, weight (P), total length (TL) and daily specific growth rate (SGR) were higher for T32 treatments (p<0.05). After 15 days, P, TL and SGR were higher for CP1000 (p<0.05). After 22 days, P and TL suffered the effect of the initial concentration of prey and water temperature with higher values for CP1000 and T32 (p<0.05). At the end of 30 days of cultivation, P was affected only by water temperature with higher values for T32 (p<0.05). The TL showed an effect of temperature and initial concentration of prey with higher values for CP1000 and T32 (p<0.05). During feeding with a commercial diet (days 16-30 of cultivation), survival was higher for T32 (94.38±6.12%) (p<0.05), with no difference for initial prey concentration. Conclusions. It is concluded that the larviculture of C. macropomum must be carried out with a temperature of 32° C and that the food management must be differentiated during the first 15 days, positively influenced in the period of feeding with ration.
Exploring the Relationship Between Instagram Use and Self-Criticism, Self-Compassion, and Body Dissatisfaction in the Spanish Population: Observational Study
Authors: Varaona Andrea , Alvarez-Mon Miguel Angel , Serrano-Garcia Irene , Díaz-Marsá Marina , Looi Jeffrey C L , Molina-Ruiz Rosa M
Published: March 2024

Background

The widespread use of online social networks, particularly among the younger demographic, has catalyzed a growing interest in exploring their influence on users’ psychological well-being. Instagram (Meta), a visually oriented platform, has garnered significant attention. Prior research has consistently indicated that Instagram usage correlates with heightened levels of perfectionism, body dissatisfaction, and diminished self-esteem. Perfectionism is closely linked to self-criticism, which entails an intense self-scrutiny and is often associated with various psychopathologies. Conversely, self-compassion has been linked to reduced levels of perfectionism and stress, while fostering greater positive affect and overall life satisfaction.

Objective

This study investigates the relationship between Instagram usage (time of use and content exposure) and users’ levels of self-compassion, self-criticism, and body dissatisfaction.

Methods

This study comprised 1051 adult participants aged between 18 and 50 years, either native to Spain or residing in the country for at least a decade. Each participant completed a tailored questionnaire on Instagram usage, along with abbreviated versions of the Self-Compassion Scale, the Body Shape Questionnaire, and the Depressive Experiences Questionnaire, spanning from January 23 to February 25, 2022.

Results

A positive correlation was observed between daily Instagram usage and self-criticism scores. Participants of all age groups who spent over 3 hours per day on Instagram exhibited higher self-criticism scores than users who spent less than 1 hour or between 1 and 3 hours per day. Contrary to previous findings, no significant relationship was detected between Instagram usage time and levels of self-compassion or body dissatisfaction. Furthermore, content centered around physical appearance exhibited a positive correlation with self-criticism and body dissatisfaction scores. Among younger participants (aged 18-35 years), those who primarily viewed beauty or fashion content reported higher self-criticism scores than those consuming science-related content. However, this association was not significant for participants aged 35-50 years. Conversely, individuals who predominantly engaged with sports or fitness or family or friends content exhibited higher levels of body dissatisfaction than those focusing on science-related content. No significant associations were observed between self-compassion scores and daily Instagram usage or most-viewed content categories.

Conclusions

The findings of this study underscore the considerable impact of Instagram usage on self-criticism and body dissatisfaction—2 variables known to influence users’ psychological well-being and be associated with various symptoms and psychological disorders.
A Comparison of Personalized and Generalized Approaches to Emotion Recognition Using Consumer Wearable Devices: Machine Learning Study
Authors: Li Joe , Washington Peter
Published: March 2024

Background

There are a wide range of potential adverse health effects, ranging from headaches to cardiovascular disease, associated with long-term negative emotions and chronic stress. Because many indicators of stress are imperceptible to observers, the early detection of stress remains a pressing medical need, as it can enable early intervention. Physiological signals offer a noninvasive method for monitoring affective states and are recorded by a growing number of commercially available wearables.

Objective

We aim to study the differences between personalized and generalized machine learning models for 3-class emotion classification (neutral, stress, and amusement) using wearable biosignal data.

Methods

We developed a neural network for the 3-class emotion classification problem using data from the Wearable Stress and Affect Detection (WESAD) data set, a multimodal data set with physiological signals from 15 participants. We compared the results between a participant-exclusive generalized, a participant-inclusive generalized, and a personalized deep learning model.

Results

For the 3-class classification problem, our personalized model achieved an average accuracy of 95.06% and an F1-score of 91.71%; our participant-inclusive generalized model achieved an average accuracy of 66.95% and an F1-score of 42.50%; and our participant-exclusive generalized model achieved an average accuracy of 67.65% and an F1-score of 43.05%.

Conclusions

Our results emphasize the need for increased research in personalized emotion recognition models given that they outperform generalized models in certain contexts. We also demonstrate that personalized machine learning models for emotion classification are viable and can achieve high performance.
Exploration and Practice of the Selection, Training and Management of College Psychological Friends—Take the School of Transportation, Hunan University of Technology as an Example
Authors: Zhou Xiao , Qian Qiurong
Published: March 2024

College students crisis occurs frequently year by year, the reason, college students themselves, weak frustration ability, lack of mental health knowledge, weak crisis identification ability, weak self-help awareness, etc. In college level, mental health, insufficient number of psychological consultants, mental health committee, peer team selection system, inadequate training, inadequate management; the above is leading to college psychological crisis prediction. At present, our school in the basis of peer members, established the peer team, the combination of two teams greatly improved the coverage of mental health work in colleges and universities, for now the construction of the team to solve the psychological problems of college students universal results, this paper in Hunan university of technology institute of transportation, for example, analysis of peer members and peer team selection, training, optimization of management ideas.
A Study on the Construction and Enhancement Strategies of Primary and Secondary School Music Teachers’ Core Literacy under the “Double Reduction” Programmer
Authors: Lin Lin
Published: March 2024

The “Double Reduction” policy is an important education reform initiative to be fully implemented by the state in 2022, which is an important policy to better promote the development of educational equity. With the gradual implementation of the “double reduction” policy, the requirements for the core qualities of primary and secondary school music teachers are also getting higher and higher, and the review of the current situation reveals that there are many problems with the core qualities of primary and secondary school music teachers.
Teaching with Conceptual Metaphors: A Cognitive linguistic approach to Japanese Idioms Teaching
Authors: Wu Li
Published: March 2024

In recent studies, the importance of developing metaphorical competence for L2 learners has been highlighted by many cognition linguists. Applying metaphor instruction in language education is increasingly considered as an effective way of improving language teaching. This paper discusses the underlying metaphorical structures and semantic construction of Japanese idiomatic expressions centered on idioms of human body. Based on that, this paper attempts to explore some strategies for Japanese idioms teaching to Chinese JFL learners from the basic perspectives of conceptual metaphors.
Personal values in relation to environmental attitudes and behavior in handicraft enterprises in Oaxaca and Guanajuato, Mexico
Authors: De Yta-Castillo Diana , Sánchez-Medina Patricia S. , Díaz-Pichardo René , Bautista-Cruz Angélica
Published: March 2024

This article explores the role of personal values and environmental attitudes as antecedents of environmental behavior in handicraft enterprises in Oaxaca and Guanajuato, Mexico. Elaborating on the value-belief norm theory (VBN), the theory of reasoned action (TRA), and the theory of planned behavior (TPB), we analyze survey data obtained from 72 handicraft enterprises using structural equation modeling. Our results show that self-transcendent and openness personal values positively and significantly impact the environmental attitudes of handicraft owners/managers as expected according to the (VBN). However, the TRA and the TPB do not explain environmental behavior in these enterprises.
La competitividad en la gestión financiera medida a través de la rentabilidad; la empresa petrolera PEMEX y su comparativo con Equinor de Noruega
Authors: Villa Luna Candy , Ríos Bolivar Humberto , Sánchez-Cano Julieta Evangelina
Published: March 2024

La presente investigación, elaboró un diagnóstico de la competitividad de dos empresas petroleras de estado, PEMEX de México y Equinor de Noruega, evaluando principalmente la influencia del indicador rentabilidad en la competitividad de ambas; para las mediciones y la fundamentación del indicador mencionado fueron utilizados los estados financieros de las mismas. El análisis cuantitativo se llevó a cabo mediante un modelo econométrico ARIMA con el objetivo de examinar el desempeño económico-financiero de ambas empresas, para un periodo del 2008 al 2019. Con los resultados obtenidos del modelo, realizamos la comparativa y una proyección de su comportamiento para los años 2020, 2021 y 2022, para ello fue utilizada la metodología Box Jenkins. Los resultados para PEMEX, mostraron que el desempeño de la empresa, en cuanto a su competitividad medido por el indicador de rentabilidad, tuvo un desarrollo ineficiente con tendencia decreciente. Y para la empresa Equinor, los resultados mostraron que tiene alta eficiencia empresarial, con tendencia estable. Esta investigación contribuye a la generación de conocimiento y proporciona información que podría influir en los tomadores de decisiones para llevar a cabo mejoras empresariales.
México, la UNAM y la Medicina Familiar cincuenta años después
Authors: Narro Robles José
Published: March 2024

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