bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptability to Balance Perturbations During Walking as a Potential Marker of Falls History in Older Adults
Authors: Gerards Marissa H. G. , Meijer Kenneth , Karamanidis Kiros , Grevendonk Lotte , Hoeks Joris , Lenssen Antoine F. , McCrum Christopher
Published: May 2021

Given that falls most commonly occur during walking due to unexpected balance perturbations like trips and slips, walking-based balance assessment including walking stability and adaptability to such perturbations could be beneficial for fall risk assessment in older adults. This cross-sectional study reanalyzed data from two larger studies conducted with the same walking protocol. Participants completed unperturbed walking trials at speeds of 0.4 m/s up to 1.8 m/s in 0.2 m/s steps. Ten unannounced treadmill belt acceleration perturbations were then applied while participants walked at equivalent stability, assessed using the margins of stability. Retrospective (12 months) falls incidence was collected to divide participants into people with and without a history of falls. Twenty older adults (mean age 70.2 ± 2.9 years) were included in this analysis; eight people with one or more recent falls and 12 people without, closely matched by sex, age and height. No significant differences were found in unperturbed walking parameters or their variability. Overall perturbation-recovery step behavior differed slightly (not statistically significant) between the groups after the first perturbation and differences became more pronounced and significant after repetition of perturbations. The No-Falls group significantly reduced the number of recovery steps needed across the trials, whereas the Falls group did not show these improvements. People with a previous fall tended to have slightly delayed and more variable recovery responses after perturbation compared to non-fallers. Non-fallers demonstrate more signs of adaptability to repeated perturbations. Adaptability may give a broader indication of the ability of the locomotor system to respond and improve responses to sudden walking perturbations than unperturbed walking variability or recovery to a single novel perturbation. Adaptability may thus be a more useful marker of falls history in older adults and should be considered in further research.
Effect of Water-Based Emulsion Core Microcapsules on Aging Resistance and Self-Repairing Properties of Water-Based Coatings on Linden
Authors: Yan Xiaoxing , Zhao Wenting , Qian Xingyu
Published: May 2021

The purpose of this paper was to discuss the best coating technology of water-based coatings containing microcapsules, and the anti-aging and self-repairing properties of water-based coatings containing microcapsules. Urea-formaldehyde encapsulated Nippon water-based emulsion microcapsules were prepared, and water-based coatings containing microcapsules were prepared. The optical and mechanical properties of the coatings under different coating technologies were investigated. Under the best coating technology, the aging resistance and self-repairing performance of the coating film were investigated. Experimental results showed that coating technology had no effect on color aberration of the coating film. The coating technology with two coats of primer, three coats of topcoat, addition of microcapsules into primer, had excellent glossiness, shock resistance of 12.0 kg·cm, adhesion of 0 grade, and fracture elongation of 26.3%. Compared with the coating film without microcapsules, the coating with microcapsules had better aging resistance and self-repairing property, and the self-repairing rate was about 20.0%. Compared with the paint film with Dulux water-based emulsion microcapsules, the paint film with Nippon water-based emulsion microcapsules had a higher self-repairing rate. This study provides a technical basis for self-repairing water-based coatings.
Field Study of Metal Oxide Semiconductor Gas Sensors in Temperature Cycled Operation for Selective VOC Monitoring in Indoor Air
Authors: Baur Tobias , Amann Johannes , Schultealbert Caroline , Schütze Andreas
Published: May 2021

More and more metal oxide semiconductor (MOS) gas sensors with digital interfaces are entering the market for indoor air quality (IAQ) monitoring. These sensors are intended to measure volatile organic compounds (VOCs) in indoor air, an important air quality factor. However, their standard operating mode often does not make full use of their true capabilities. More sophisticated operation modes, extensive calibration and advanced data evaluation can significantly improve VOC measurements and, furthermore, achieve selective measurements of single gases or at least types of VOCs. This study provides an overview of the potential and limits of MOS gas sensors for IAQ monitoring using temperature cycled operation (TCO), calibration with randomized exposure and data-based models trained with advanced machine learning. After lab calibration, a commercial digital gas sensor with four different gas-sensitive layers was tested in the field over several weeks. In addition to monitoring normal ambient air, release tests were performed with compounds that were included in the lab calibration, but also with additional VOCs. The tests were accompanied by different analytical systems (GC-MS with Tenax sampling, mobile GC-PID and GC-RCP). The results show quantitative agreement between analytical systems and the MOS gas sensor system. The study shows that MOS sensors are highly suitable for determining the overall VOC concentrations with high temporal resolution and, with some restrictions, also for selective measurements of individual components.
Improving the Retrieval of Cloudy Atmospheric Profiles from Brightness Temperatures Observed with a Ground-Based Microwave Radiometer
Authors: Li Qing , Wei Ming , Wang Zhenhui , Jiang Sulin , Chu Yanli
Published: May 2021

Atmospheric temperature and humidity retrievals from ground-based microwave remote sensing are useful in a variety of meteorological and environmental applications. Though the influence of clouds is usually considered in current retrieval algorithms, the resulting temperature and humidity estimates are still biased high in overcast conditions compared to radiosonde observations. Therefore, there is a need to improve the quality of retrievals in cloudy conditions. This paper presents an approach to make brightness temperature (TB) correction for cloud influence before the data can be used in the inversion of vertical profiles of atmospheric temperature and humidity. A three-channel method is proposed to make cloud parameter estimation, i.e., of the total 22 channels of the ground-based radiometer, three are adopted to set up a relationship between cloud parameters and brightness temperatures, so that the observations from the three channels can be used to estimate cloud thickness and water content and complete the cloud correction for the rest of the channels used in the retrieval. Based on two years of data from the atmosphere in Beijing, a comparison of the retrievals with radiosonde observations (RAOB) shows: (1) the temperature retrievals from this study have a higher correlation with RAOB and are notably better than in the vendor-provided LV2. The bias of the temperature retrievals from this study is close to zero at all heights, and the RMSE is greatly reduced from >5 °C to <2 °C in the layer, from about 1.5 km up to 5 km. The temperature retrievals from this study have higher correlation with RAOB data compared to the vendor-provided LV2, especially at and above a 2 km height. (2) The bias of the water vapor density profile from this study is near to zero, while the LV2 has a positive bias as large as 4 g/m3. The RMSE of the water vapor density profile from this study is <2 g/m3, while the RMSE for LV2 is as large as 10 g/m3. That is, both the bias and RMSE from this study are evidently less than the LV2, with a greater improvement in the lower troposphere below 5 km. Correlation with RAOB is improved even more for the water vapor density. The correlation of the retrievals from this study increases to one within the boundary layer, but the correlation of LV2 with RAOB is only 0.8 at 0.5 km height, 0.7 at 1 km, and even less than 0.5 at 2 km. (3) A parameter named the Cloud Impact index, determined by cloud water concentration and cloud thickness, together with the cloud base height, has been defined to show that both BIAS and RMSE of “high-CI subsample” are larger than those of the “low-CI subsample”, indicating that high-CI cloud has a higher impact on the retrievals and the correction for cloud influence is more necessary.
Age-Specific Excretion of Calcium, Oxalate, Citrate, and Glycosaminoglycans and Their Ratios in Healthy Children and Children with Urolithiasis
Authors: Turudic Daniel , Golubic Anja Tea , Lovric Mila , Bilic Marko , Milosevic Danko
Published: May 2021

We analyzed children with urolithiasis with age- and gender-matched healthy children. Calcium (mmol/mmol creatinine) and the calcium/citrate ratio (mol/mmol) are the only variables that differentiate children before puberty from healthy children (ROC analysis confirmed only calcium/citrate as a significant variable with cut-off value > 0.84). Peri-pubertal children are distinguished from age- and gender-matched healthy children by the following variables: citrate (mmol/mol creatinine), calcium/citrate (mol/mmol), oxalate/glycosaminoglycans (mmol/g), oxalate/citrate ratios (mmol/mmol) and oxalate/(citrate × glycosaminoglycans) (mol oxalate × mol creatinine)/(mol citrate × g glycosaminoglycans). All variables were confirmed by ROC analysis with cut-off values ≤ 327.87, >1.02, >11.24, >0.12 and >0.03, respectively. These results indicate a different risk of urinary stones development before puberty vs. pubertal/postpubertal children and increasing importance (deficiency) of citrate and glycosaminoglycans in such children. J48 classifier confirmed the importance of the oxalate/(citrate × glycosaminoglycans) and the calcium/citrate ratios (Ox/Cit × GAG 0.22 and Cit/GAG 0.612) with the practically applicable classification tree for distinguishing between pubertal/postpubertal children with urolithiasis with age- and gender-matched healthy children.
Frontotemporal Transcranial Direct Current Stimulation Decreases Serum Mature Brain-Derived Neurotrophic Factor in Schizophrenia
Authors: Adam Ondine , Psomiades Marion , Rey Romain , Mandairon Nathalie , Suaud-Chagny Marie-Francoise , Mondino Marine , Brunelin Jerome
Published: May 2021

Although transcranial direct current stimulation (tDCS) shows promise as a treatment for auditory verbal hallucinations in patients with schizophrenia, mechanisms through which tDCS may induce beneficial effects remain unclear. Evidence points to the involvement of neuronal plasticity mechanisms that are underpinned, amongst others, by brain-derived neurotrophic factor (BDNF) in its two main forms: pro and mature peptides. Here, we aimed to investigate whether tDCS modulates neural plasticity by measuring the acute effects of tDCS on peripheral mature BDNF levels in patients with schizophrenia. Blood samples were collected in 24 patients with schizophrenia before and after they received a single session of either active (20 min, 2 mA, n = 13) or sham (n = 11) frontotemporal tDCS with the anode over the left prefrontal cortex and the cathode over the left temporoparietal junction. We compared the tDCS-induced changes in serum mature BDNF (mBDNF) levels adjusted for baseline values between the two groups. The results showed that active tDCS was associated with a significantly larger decrease in mBDNF levels (mean −20% ± standard deviation 14) than sham tDCS (−8% ± 21) (F = 5.387; p = 0.030; η2 = 0.205). Thus, mature BDNF may be involved in the beneficial effects of frontotemporal tDCS observed in patients with schizophrenia.
Strategies for Effective Waste Reduction and Management of Building Construction Projects in Highly Urbanized Cities—A Case Study of Hong Kong
Authors: Yu Ann T. W. , Wong Irene , Wu Zezhou , Poon Chi-Sun
Published: May 2021

Hong Kong is a densely populated city with high-rise developments, and as in other metropolitan cities, the amount of waste generated from construction projects in the city is increasing annually. The capacity of existing landfills is expected to be saturated by the 2020s. Construction waste management has been implemented for years but the performance is still not satisfactory. The aim of this research paper is to explore and formulate strategies and measures for effective construction waste management and reduction in highly urbanized cities such as Hong Kong. A desktop study on construction waste management practices was carried out for a preliminary understanding of the current situation in Hong Kong. Semistructured interviews and focus group meetings were further conducted to shed light on how to improve construction waste reduction and management in Hong Kong. The main contributions of this research study are the potential short-term, medium-term, and long-term strategies, which are related to the design stage, tender stage, construction stage, and government support. The five major strategies recommended are financial benefits to stakeholders, public policies in facilitating waste sorting, government supports for the green building industry, development of a mature recycling market, and education and research in construction waste minimization and management.
Current Treatment Options in CLL
Authors: Bewarder Moritz , Stilgenbauer Stephan , Thurner Lorenz , Kaddu-Mulindwa Dominic
Published: May 2021

After impressive developments in recent years with the rise of new targeted agents, chemoimmunotherapy (CIT) only plays a minor role in the treatment of patients with chronic lymphocytic leukemia (CLL). Inhibitors of the Bruton tyrosine kinase (BTK), such as ibrutinib or more recently acalabrutinib, are highly effective, even in poor-risk or chemo-refractory patients. Venetoclax, an inhibitor of the anti-apoptotic BCL2 protein and, to a lesser extent, phosphoinositide-3 kinase (PI3K) delta inhibitors, add to the armamentarium of targeted agents for the treatment of CLL. Furthermore, anti-CD20 monoclonal antibodies are used very successfully either alone or in combination with BTK, BCL2 or PI3K inhibitors. Despite these advances, there is still an ongoing pursuit for new therapeutic approaches in the treatment of CLL. An even bigger challenge poses the determination of the optimal combination and sequence of those drugs. Here, we give an overview of current treatment options in CLL, weighing the advantages and disadvantages of each approach in the light of different clinical settings.
Thymic Carcinomas and Second Malignancies: A Single-Center Review
Authors: Badve Sunil S. , Dougherty Rachel , Balatico Michael , Kesler Kenneth A. , Loehrer Patrick , Gökmen-Polar Yesim
Published: May 2021

Thymic carcinomas account for less than 0.01% of new cancer diagnoses annually and are more aggressive than thymomas. Autoimmune disorders have been associated with thymomas and only recently with thymic carcinomas. Second malignancies are well described after thymomas. The aim of this study was to analyze the incidence of second malignancies in patients with thymic carcinomas. All cases of thymic carcinomas were identified from the pathology archives of Indiana University. Histological materials were reviewed and further correlated with clinical data to identify incidence of second cancers in patients with thymic carcinomas. Histological material was available for review in 92 cases of thymic carcinoma. Clinical data were available for 85 patients. Fourteen of these (16.5%) patients had a second malignancy; these included small cell lung carcinoma, “testicular cancer”, embryonal carcinoma, seminoma, breast carcinoma (two cases), prostatic adenocarcinoma, Hodgkin’s lymphoma, thyroid carcinoma, bladder carcinoma (two cases), renal cell carcinoma, and melanoma. The latter could precede, be concurrent with, or follow the diagnosis thymic carcinoma. The incidence of second cancers in patients with thymic carcinomas is similar to that reported for thymomas. Abnormalities in immunological surveillance may be responsible for this high incidence of second malignancies in thymic tumors.
Proof of Concept of a Binary Blood Assay for Predicting Radiosensitivity
Authors: Deneuve Sophie , Mirjolet Céline , Bastogne Thierry , Duclos Mirlande , Retif Paul , Zrounba Philippe , Roux Pierre-Eric , Poupart Marc , Vogin Guillaume , Foray Nicolas , Pereira Sandrine
Published: May 2021

Radiation therapy (RT), either alone or in combination with surgery and/or chemotherapy is a keystone of cancers treatment. Early toxicity is common, sometimes leading to discontinuation of treatment. Recent studies stressed the role of the phosphorylated ATM (pATM) protein in RT-toxicity genesis and its ability in predicting individual radiosensitivity (IRS) in fibroblasts. Here we assessed the reliability of the pATM quantification in lymphocytes to predict IRS. A first retrospective study was performed on 150 blood lymphocytes of patients with several cancer types. Patients were divided into 2 groups, according to the grade of experienced toxicity. The global quantity of pATM molecules was assessed by ELISA on lymphocytes to determine the best threshold value. Then, the binary assay was assessed on a validation cohort of 36 patients with head and neck cancers. The quantity of pATM molecules in each sample of the training cohort was found in agreement with the observed Common Terminology Criteria for Adverse Events (CTCAE) grades with an AUC = 0.71 alone and of 0.77 combined to chemotherapy information. In the validation cohort, the same test was conducted with the following performances: sensitivity = 0.84, specificity = 0.54, AUC = 0.70 and 0.72 combined to chemotherapy. This study provides the basis of an easy to perform assay for clinical use.
Diagnostic and Prognostic Value of miR-16, miR-146a, miR-192 and miR-221 in Exosomes of Hepatocellular Carcinoma and Liver Cirrhosis Patients
Authors: Fründt Thorben , Krause Linda , Hussey Elaine , Steinbach Bettina , Köhler Daniel , von Felden Johann , Schulze Kornelius , Lohse Ansgar W. , Wege Henning , Schwarzenbach Heidi
Published: May 2021

We aimed to identify a specific microRNA (miRNA) pattern to determine diagnostic and prognostic value in plasma exosomes of hepatocellular carcinoma (HCC) patients. A two-stage study was carried out: exosomal miRNAs were quantified in plasma of HCC patients and healthy individuals by PCR-based microarray cards containing 45 different miRNAs (training cohort). Then, four deregulated miRNAs (miR-16, miR-146a, miR-192, and miR-221) were quantified in the validation analysis using exosomes derived from 85 HCC patients, 50 liver cirrhosis patients, and 20 healthy individuals. Exosomal miR-146a (p = 0.0001), miR-192 (p = 0.002) and miR-221 (p = 0.032) were upregulated only in HCC patients. Repeated 10-fold cross validation showed that miR-146a differentiated HCC from liver cirrhosis patients with AUC of 0.80 ± 0.14 (sensitivity: 81 ± 13%, specificity: 58 ± 22%) in a logistic regression model. High miR-192 presence is associated with poor overall survival (OS) in all HCC patients (p = 0.027) and was predictor of OS in HCC patients in an uni- and multivariate Cox regression model. Moreover, decreased miR-16 levels correlated with OS in liver cirrhosis patients (p = 0.034). Our results emphasized that exosomes secreted into the plasma carry differentially expressed miRNAs of which in particular, miR-192, miR-146, and miR-16 are promising diagnostic and prognostic markers for both HCC and liver cirrhosis patients.
Spray Pyrolysis Synthesis of Pure and Mg-Doped Manganese Oxide Thin Films
Authors: Dahamni Mohamed Amine , Ghamnia Mostefa , Naceri Salah Eddine , Fauquet Carole , Tonneau Didier , Pireaux Jean-Jacques , Bouadi Abed
Published: May 2021

Pure and Mg-doped manganese oxide thin films were synthesized on heated glass substrates using the spray pyrolysis technique. The surface chemical composition was investigated by the use of X-ray photoelectron spectroscopy (XPS). Structural and morphological properties were studied by using X-ray diffraction (XRD), scanning electron microscope (SEM) and atomic force microscopy (AFM). Optical properties were characterized by UV-visible spectroscopy. XPS spectra showed typical Mn (2p3/2), (2p1/2) and O (1s) peaks of Mn3O4 with a slight shift attributed to the formation of different chemical states of manganese. XRD analysis revealed the tetragonal phase of Mn3O4 with a preferred (211) growth orientation that improved with Mg-doping; likewise, grain size is observed to increase with the Mg doping. SEM images of Mn3O4 films showed rough surfaces composed of uniformly distributed nanograins whose size decreases with the Mg-doping. The manganese oxide films surface observed in AFM show a textured, rough and porous surface. The combination of transmittance and absorption data in the UV-visible range allowed determining the energy values of the Eg band gap (1.5–2.5 eV). The decrease of the band gap with the Mg-doping increase is attributed to the influence of the greater size of the Mg2+ ion in the manganese oxide lattice.
Serum Anti-Collagen IV IgM and IgG Antibodies as Indicators of Low Vascular Turnover of Collagen IV in Patients with Long-Term Complications of Type 2 Diabetes
Authors: Kostov Krasimir , Blazhev Alexander
Published: May 2021

Thickening of the vascular basement membrane (BM) is a fundamental structural change in the small blood vessels in diabetes. Collagen type IV (CIV) is a major component of the BMs, and monitoring the turnover of this protein in type 2 diabetes (T2D) can provide important information about the mechanisms of vascular damage. The aim of the study was through the use of non-invasive biomarkers of CIV (autoantibodies, derivative peptides, and immune complexes) to investigate vascular turnover of CIV in patients with long-term complications of T2D. We measured serum levels of these biomarkers in 59 T2D patients with micro- and/or macrovascular complications and 20 healthy controls using an ELISA. Matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9) were also tested. In the T2D group, significantly lower levels of CIV markers and significantly higher levels of MMP-2 and MMP-9 were found compared to controls. A significant positive correlation was found between IgM antibody levels against CIV and MMP-2. These findings suggest that vascular metabolism of CIV is decreased in T2D with long-term complications and show that a positive linear relationship exists between MMP-2 levels and CIV turnover in the vascular wall.
Updated Incidence of Thyroid Cancer in the North East Region of Romania after 35 Years of Chernobyl Fallout. Is There a Link between?
Authors: Teodoriu Laura , Ungureanu Maria Christina , Leustean Letitia , Preda Cristina , Ciobanu Delia , Grierosu Irena , Matei Mioara , Iacob Roxana , Stefanescu Cipriana
Published: May 2021

Thyroid cancer (TC) represents a worldwide problem, the consistent growth of the incidence increment issues about management of risk factors and curative treatment. Updated statistical data are not complete in the North East region of Romania and need to be improved. Therefore, through this study, we aim to renew the existing data on thyroid cancer. We conducted a retrospective study covering a period of 10 years. Data were collected from a hospital information system (InfoWorld) between 2009 and 2019. Patients’ age groups were stratified in relation with the age at the moment of the Chernobyl event. A database was obtained (Microsoft Excel) and statistical correlations were applied. In the studied period, 1159 patients were diagnosed: 968 females and 191 males, distributed by region, with the highest addressability in Iasi (529), followed by neighboring counties. Age distribution displayed that most of the thyroid cancers were in the range 4060 years old (50.94%), followed by 60–80 years old (32.41%). Most patients were diagnosed with papillary carcinoma 63.10%, then follicular 14.7%, medullary 6.74% and undifferentiated 1.02%. Romania was in the vicinity of the radioactive cloud at Chernobyl fallout, so we must deliberate whether the increased incidence of thyroid cancer in the age group 40–60 years is associated with radiogenicity (iodine 131) given the fact that over has 35 years and the half-life of other radioisotopes like Caesium-137 and Strontium -90 is completed.
BRCA Germline Mutations in Prostate Cancer: The Future Is Tailored
Authors: Crocetto Felice , Barone Biagio , Caputo Vincenzo Francesco , Fontana Matteo , de Cobelli Ottavio , Ferro Matteo
Published: May 2021

Prostate cancer (PCa) is the second most common neoplasm in men and the fifth leading cause of death worldwide [...]
Solar Tracking System with New Hybrid Control in Energy Production Optimization from Photovoltaic Conversion for Polish Climatic Conditions
Authors: Frydrychowicz-Jastrzębska Grażyna , Bugała Artur
Published: May 2021

This paper presents a comparison of the 24-month production of electricity and momentary power by two photovoltaic systems with a nominal power of 1000 Wp each. The analyzed systems are connected to the power grid and operate independently: a fixed system with optimal all-year-round angular positioning and an astronomical-sensor-controlled dual-axis tracking system. The systems under consideration consist of PV modules with a unit electrical power of 200 Wp, and the production technology of those modules is the same. The tested systems were located on the building rooftop of the Faculty of Control, Robotics and Electrical Engineering of the Poznan University of Technology in Poland (Central Poland, 52°24.4152′ N, 16°55.7958′ E) at a height of 30 m above ground level. The measurements take into account the consumption of electricity by the actuators of the dual-axis positioning system. Increases in the produced electricity by 35.6% and 44.7% were observed for local climatic conditions during the first and second measuring years, respectively, when comparing the use of the dual-axis tracking system with the use of fixed units. Results show that the analyzed region of central Poland, represented by the city of Poznań, creates favorable climatic conditions for the use of astronomical-sensor spatial positioning systems for photovoltaic modules, also in the case of a significant share of diffuse solar radiation in the global value. These results may make the planning of solar tracking investments easier and help with the estimate calculations of the total investment return period and operational costs.
Resistance of Wood Treated with Iron Compounds against Wood-Destroying Decay and Mould Fungi
Authors: Aleinikovas Marius , Varnagirytė-Kabašinskienė Iveta , Povilaitienė Aistė , Šilinskas Benas , Škėma Mindaugas , Beniušienė Lina
Published: May 2021

Treatment of wood with various physical and chemical factors can change the number of wood parameters, which can also lead to changes in resistance to wood-destroying fungi. This study evaluates the effects of hydrothermal treatments (additives Fe2O3 or FeCl3 with and without commercial tannins, also without additives and fresh wood) on decay and mould fungi resistance of modified wood of Scots pine (Pinus sylvestris), Norway spruce (Picea abies), Douglas fir (Pseudotsuga menziesii), walnut (Juglans regia), and Norway maple (Acer platanoides). For wood samples, the resistance against wood decay fungi Trametes versicolor (white rot) and Coniophora puteana (brown rot) and the resistance against mould fungi Aspergillus niger and Penicillium sp. were assessed. The study findings showed that wood modified with iron compounds could cause a higher resistance to wood-destroying fungi. The weight losses of the modified and control wood, caused by T. versicolor and C. puteana, differed for coniferous and deciduous: the average weight loss of treated pine, spruce, and fir wood caused by C. puteana was higher than that caused by T. versicolor, while these differences on maple and walnut wood were not significant. The wood hydrothermal treatment with Fe2Cl3 with and without tannins significantly reduced the weight loss caused by T. versicolor and C. puteana, and the treatment with Fe2O3 slightly improved the decay resistance. For the wood, hydrothermally modified with FeCl3 and FeCl3 + tannins, the mould area for both tested Aspergillus niger and Penicillium sp. was smallest for the wood of all tested tree species compared to other treatments. A different response was obtained for coniferous and deciduous tree species wood. The spruce wood, followed by fir wood, treated with FeCl3 with and without tannins, was the most resistant against the mould fungi. Relatively low resistance against the mould fungi was fixed for the maple wood treated by various iron compounds, except the treatment with Fe2O3 + tannins, which gave a very positive response against the Penicillium sp.
Evaluation of Magnus Force on Check Ball Behavior in a Hydraulic L Shaped Pipe
Authors: Kajiwara Shinji
Published: May 2021

This paper presents the effect of the rotational speed of a check ball in a hydraulic L-tube on the translational motion caused by the Magnus effect. A spring-driven ball check valve is one of the most important components of a hydraulic system and controls the position of the ball to prevent backflow. To simplify the structure, the springs must be eliminated. To this end, it is necessary to clarify the flow pattern of the check ball in an L-shaped pipe and the rotational and translational behaviors of the ball. In this study, the position of the inlet pipe and the availability of the check were determined using Computer Aided Engineering (CAE) tools. By moving the position of the inlet pipe from the top to the bottom of the housing, the direction of the rotation of the ball was reversed, and the behavior changed significantly. It was found that the Magnus force, which causes the ball to levitate by rotating it in the opposite direction to the flow, acts to shorten the floating time.
Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study
Authors: Botelho João , Machado Vanessa , Mendes José João , Mascarenhas Paulo
Published: May 2021

The latest evidence revealed a possible association between periodontitis and Parkinson’s disease (PD). We explored the causal relationship of this bidirectional association through two-sample Mendelian randomization (MR) in European ancestry populations. To this end, we used openly accessible data of genome-wide association studies (GWAS) on periodontitis and PD. As instrumental variables for periodontitis, seventeen single-nucleotide polymorphisms (SNPs) from a GWAS of periodontitis (1817 periodontitis cases vs. 2215 controls) and eight non-overlapping SNPs of periodontitis from an additional GWAS for validation purposes. Instrumental variables to explore for the reverse causation included forty-five SNPs from a GWAS of PD (20,184 cases and 397,324 controls). Multiple approaches of MR were carried-out. There was no evidence of genetic liability of periodontitis being associated with a higher risk of PD (B = −0.0003, Standard Error [SE] 0.0003, p = 0.26). The eight independent SNPs (B = −0.0000, SE 0.0001, p = 0.99) validated this outcome. We also found no association of genetically primed PD towards periodontitis (B = −0.0001, SE 0.0001, p = 0.19). These MR study findings do not support a bidirectional causal genetic liability between periodontitis and PD. Further GWAS studies are needed to confirm the consistency of these results.
Challenges and Opportunities Presented by Current Techniques for Detecting Schistosome Infections in Intermediate Host Snails: A Scoping Review
Authors: Nwoko Onyekachi Esther , Mogaka John J. O. , Chimbari Moses John
Published: May 2021

Schistosomiasis, a neglected tropical disease (NTD), causes morbidity and mortality in over 250 million people globally. And 700 million people are at risk of contracting it. It is caused by a parasite of the genus Schistosoma. Freshwater snails of the family Planorbidae are of public health significance as they are intermediate hosts of these highly infective flukes. Accurate diagnostic techniques to detect schistosome infections in intermediate host snails (IHS) and environmental surveillance are needed to institute measures for the interruption of transmission and eventual elimination. We carried out a systematic review of the literature to assess advantages and limitations of different diagnostic techniques for detecting schistosome infections in snails. Literature from Scopus, Web of Science, and PubMed databases from 2008 to 2020 were searched using combinations of predefined search terms with Boolean operators. The studies revealed that conventional diagnostics are widely used, although they are labor-intensive, have low specificity and sensitivity levels, and cannot detect prepatent infections. Whereas more advanced techniques such as immunological, nucleic-acid amplification, and eDNA diagnostics have high sensitivity and specificity levels, they are costly, hence, not suitable for field applications and large-scale surveys. Our review highlights the importance of designing and developing innovative diagnostics that are high in specificity and sensitivity as well as affordable and technically feasible for use in field laboratories and for large-scale surveys.
Development of Creative Intelligence in Physical Education and Sports Science Students through Body Expression
Authors: Vidaci Andreea , Vega-Ramírez Lilyan , Cortell-Tormo Juan Manuel
Published: May 2021

Body expression can enhance movement creativity and at the same time promote the growth of creative intelligence in college age. The aim of this study was to analyze the influence of an intervention in body expression classes on the creative intelligence of university students. The 49 participants aged 19 to 38 years engaged in the body expression course for seven weeks, 3 h per week. The Creative Intelligence test (CREA) was applied as an evaluative method to obtain the initial data and after the intervention the test was reapplied. Pre- and post-test results were analyzed and compared by gender and type of sporting background (team or individual sports). The results indicate an overall improvement in creative intelligence with a significant difference between the two evaluations (p < 0.001). Women started with a higher score than men, and although an improvement in their final mean score could be observed, it was not significant. Men, on the other hand, had noted a significant increase (p < 0.001) of these values in the post-test. Regarding the type of sports, at the beginning of the study, both groups had similar results; however, in the final test, the team sports players obtained better scores. In conclusion, body expression, thanks to its content focused on artistic-creative development, has been shown to be useful in the general progression of creative intelligence in college age.
Prevalence of Parental Alcohol Problems among a General Population Sample of 28,047 Norwegian Adults: Evidence for a Socioeconomic Gradient
Authors: Haugland Siri H. , Elgán Tobias H.
Published: May 2021

The aim of the study presented here was to estimate the prevalence of parental alcohol problems during childhood in a general population of Norwegian adults, and to investigate associations between parental alcohol problems during childhood and lower socioeconomic status in adulthood. This cross-sectional study recruited 28,047 adults (≥18 years) to an online health survey (Norwegian Counties Public Health Surveys). We evaluated demographic and socioeconomic measures and responses to a shortened version of the Children of Alcoholics Screening Test (CAST-6) scale to assess whether respondents perceived parental alcohol consumption during childhood as problematic. Respondents reported parental alcohol problems at a rate of 15.6%, but the experience was more prevalent among adults with a low education (20.0%), compared to those with intermediate (16.4%) or high educations (13.8%, χ2(2) = 87.486, p < 0.001), and it was more common among respondents with low economic capabilities (21.1%) compared to those with middle/high capabilities (14.2%, χ2(1) = 162.089, p < 0.001). Parental alcohol problems were most prevalent among respondents that received welfare benefits (24.5%). Multivariable logistic regression analyses revealed associations between parental alcohol problems and low socioeconomic status in adulthood; odds ratios (95% confidence intervals) ranged from 1.33 (1.25–1.42) to 1.89 (1.72–2.06). From a public health perspective, children who grow up with parental alcohol problems should be reached through both universal and selective interventions.
Differences in Cumulative Long-Term Care Costs by Community Activities and Employment: A Prospective Follow-Up Study of Older Japanese Adults
Authors: Saito Masashige , Kondo Naoki , Aida Jun , Saito Junko , Anezaki Hisataka , Ojima Toshiyuki , Kondo Katsunori
Published: May 2021

We evaluated differences in the cumulative benefit costs of public long-term care (LTC) insurance services by employment status and frequency of community activities. A baseline survey was conducted on functionally independent older people from 12 municipalities as a nationwide survey from 2010 to 2011. Employment status was dichotomized, and community activity was assessed based on the frequency of participation in hobbies, sports clubs, or volunteering. We followed the respondents’ LTC service costs over a period of 6 years using public LTC claim records (n = 46,616). We adopted a classical linear regression analysis and an inverse probability weighting estimation with multiple imputation for missing values. Compared with non-participation in each community activity, the cumulative LTC costs among individuals who participated in hobbies or sports group activities at least twice a week were 1.23 (95% confidence interval: 0.73–1.72) to 1.18 (0.68–1.67) thousand USD lower per person over the 6-year period (28.7% to 30.1% lower, respectively). Similarly, the costs for employed persons were 0.55 (0.20–0.90) to 0.64 (0.29–0.99) thousand USD per person lower than among retirees (14.5% to 16.9% lower). Promoting employment opportunities and frequent participation in community activities among older adults may help reduce future LTC costs by around 20% as a result of extending healthy longevity.
Multi-Criteria Evaluation and Sensitivity Analysis for the Optimal Location of Constructed Wetlands (METland) at Oceanic and Mediterranean Areas
Authors: Peñacoba-Antona Lorena , Gómez-Delgado Montserrat , Esteve-Núñez Abraham
Published: May 2021

METland is a new variety of Constructed Wetland (CW) for treating wastewater where gravel is replaced by a biocompatible electroconductive material to stimulate the metabolism of electroactive bacteria. The system requires a remarkably low land footprint (0.4 m2/pe) compared to conventional CW, due to the high pollutant removal rate exhibited by such microorganisms. In order to predict the optimal locations for METland, a methodology based on Multi-Criteria Evaluation (MCE) techniques applied to Geographical Information Systems (GIS) has been proposed. Seven criteria were evaluated and weighted in the context of Analytical Hierarchy Process (AHP). Finally, a Global Sensitivity Analysis (GSA) was performed using the Sobol method for resource optimization. The model was tested in two locations, oceanic and Mediterranean, to prove its feasibility in different geographical, demographic and climate conditions. The GSA revealed as conclusion the most influential factors in the model: (i) land use, (ii) distance to population centers, and (iii) distance to river beds. Interestingly, the model could predict best suitable locations by reducing the number of analyzed factors to just such three key factors (responsible for 78% of the output variance). The proposed methodology will help decision-making stakeholders in implementing nature-based solutions, including constructed wetlands, for treating wastewater in rural areas.
The Impact of Health Literacy on Knowledge and Attitudes towards Preventive Strategies against COVID-19: A Cross-Sectional Study
Authors: Silva Maria João , Santos Paulo
Published: May 2021

The coronavirus disease 2019 (COVID-19) pandemic introduced a set of mitigation measures based on personal behavior and attitudes. In the absence of vaccination or specific treatment, it became essential to comply with these measures to reduce infection transmission. Health literacy is the basis for changing behaviors. AIM: To characterize the impact of literacy on knowledge and attitudes towards preventive strategies against COVID-19. METHODS: This cross-sectional study involved an online questionnaire applied to students of the University of Porto, Portugal, containing questions about knowledge and attitudes towards COVID-19 based on European guidelines. Health literacy was assessed through the Newest Vital Sign questionnaire. Logistic regression estimated the relationship between health literacy and both knowledge and attitudes. RESULTS: We included 871 participants (76.3% female), with a median age of 22 years old. We found adequate literacy in 92% of our sample, irrespective of gender and age. In the global analysis, 78.6% of the participants had adequate knowledge, and 90.4% had adequate attitudes. We found that better literacy was significantly associated with attitudes towards COVID-19, but not with better knowledge. In a model adjusted for gender, age, and previous education in the health field, female gender and previous education in the health field were associated with better knowledge and attitudes. CONCLUSION: Better health literacy is associated with better attitudes towards preventive strategies against COVID-19. We should invest in ways to improve health literacy, so we can improve people’s attitudes and consequently reduce coronavirus’ transmission.
Stigma and Discrimination towards People Living with HIV in the Context of Families, Communities, and Healthcare Settings: A Qualitative Study in Indonesia
Authors: Fauk Nelsensius Klau , Hawke Karen , Mwanri Lillian , Ward Paul Russell
Published: May 2021

HIV stigma and discrimination are a major challenge facing people living with HIV (PLHIV) globally. As part of a larger qualitative study with PLHIV in Yogyakarta and Belu, Indonesia, this paper describes the participants’ perceptions about drivers of HIV stigma and discrimination towards them within families, communities and healthcare settings, and highlights issues of HIV stigma as a social process. Participants were recruited using a snowball sampling technique. Data analysis was guided by the framework analysis for qualitative data, and conceptualization and discussion of the study findings were guided by the HIV stigma framework. The findings showed that participants experienced stigma and discrimination across settings, including in families and communities by family and community members, and in healthcare settings by healthcare professionals. The lack of knowledge about HIV, fear of contracting HIV, social and moral perceptions about HIV and PLHIV were perceived facilitators or drivers of stigma and discrimination towards PLHIV. HIV stigma and discrimination were also identified as a process linked to the whole groups of people within families or communities, which occurred within social context in Yogyakarta and Belu. The findings indicate the need for HIV education for family and community members, and healthcare providers to enhance their knowledge of HIV and improve acceptance of PLHIV within families, communities and healthcare settings.
Prevalence and Demographic Correlates of Substance Use among Adults with Mental Illness in Eastern Cape, South Africa: A Cross-Sectional Study
Authors: Tindimwebwa Linda , Ajayi Anthony Idowu , Adeniyi Oladele Vincent
Published: May 2021

This study reports on the prevalence and demographic correlates of substance use among individuals with mental illness in the Eastern Cape, South Africa. This cross-sectional study was conducted in the Outpatient Clinic of a large hospital in the Eastern Cape, South Africa. A pre-validated tool on alcohol and psychoactive drug use was administered to 390 individuals with mental illness. Multivariable logistic regression models were fitted to explore the demographic correlates of alcohol and psychoactive drug use. Of the total participants (N = 390), 64.4% and 33.3% reported lifetime (ever used) and past-year use of alcohol, respectively, but the prevalence of risky alcohol use was 18.5%. After adjusting for relevant covariates, only male sex, younger age, and rural residence remained significantly associated with risky alcohol use. The prevalence of ever-use and past-year use of psychoactive substances was 39.7% and 17.4%, respectively. The most common substance ever used was cannabis (37.4%). Male sex, younger age, owning a business, and being unemployed were significantly associated with higher odds of lifetime and past-year use of psychoactive substances. Findings highlight the need for dedicated infrastructure and staff training in the management of these dual diagnoses in the region.
The Influence of Sunlight Exposure and Sun Protecting Behaviours on Allergic Outcomes in Early Childhood
Authors: Rueter Kristina , Jones Anderson P. , Siafarikas Aris , Chivers Paola , Prescott Susan L. , Palmer Debra J.
Published: May 2021

The dramatic rise in allergic disease has occurred in tandem with recent environmental changes and increasing indoor lifestyle culture. While multifactorial, one consistent allergy risk factor has been reduced sunlight exposure. However, vitamin D supplementation studies have been disappointing in preventing allergy, raising possible independent effects of ultraviolet (UV) light exposure. The aim of this study was to examine whether UV light exposure influences the development of allergic disease in early childhood. Direct sunlight exposure (290–380 nm) in early infancy was measured via UV dosimeters. Outdoor exposure, sun protective behaviours, and allergy outcomes were assessed over the first 2.5 years of life with clinical assessment appointments at 3, 6, 12 and 30 months of age. Children with eczema had less (p = 0.038) direct UV light exposure between 0–3 months of age (median (IQR) 747 (473–1439) J/m2) than children without eczema (median (IQR) 1204 (1717–1843) J/m2); and less outdoor exposure time (7 min/day) between 11 a.m. and 3 p.m. compared to children without eczema (20 min/day, p = 0.011). These associations were seen independent of vitamin D status, and after adjusting for other potential confounders. Whilst we could not find any associations between direct UV light exposure and other allergic disease outcomes, exposure to UV light appears to be beneficial in reducing the risk of eczema development in early childhood. Further research is required to determine optimal levels of UV light exposure while balancing the potential risks.