bluuebunny/crossref_metadata_2025 huggingface dataset:
Reduction of Schottky Barrier Height at Graphene/Germanium Interface with Surface Passivation
Authors: Courtin Jules , Moréac Alain , Delhaye Gabriel , Lépine Bruno , Tricot Sylvain , Turban Pascal , Schieffer Philippe , Le Breton Jean-Christophe
Published: November 2019

Fermi level pinning at metal/semiconductor interfaces forbids a total control over the Schottky barrier height. 2D materials may be an interesting route to circumvent this problem. As they weakly interact with their substrate through Van der Waals forces, deposition of 2D materials avoids the formation of the large density of state at the semiconductor interface often responsible for Fermi level pinning. Here, we demonstrate the possibility to alleviate Fermi-level pinning and reduce the Schottky barrier height by the association of surface passivation of germanium with the deposition of 2D graphene.
Novel Generalized Three-Step Phase-Shifting Interferometry with a Slight-Tilt Reference
Authors: Xu Xianfeng , Ma Tianyu , Jiao Zhiyong , Xu Liang , Dai Dejun , Qiao Fangli , Poon Ting-Chung
Published: November 2019

A convenient and powerful method is proposed and presented to find the unknown phase shifts in three-step generalized phase-shifting interferometry. A slight-tilt reference of 0.1 degrees is employed. As a result, the developed theory shows that the unknown phase shifts can be simply extracted by subtraction operations. Also, from the theory developed, the tilt angle of the tilt reference can also be calculated, which is important as it allows us to extract the object wave precisely. Numerical simulations and optical experiments were performed to demonstrate the validity and efficiency of the proposed method. The proposed slight-tilt reference allows the full and efficient use of the space-bandwidth product of the limited resolution of digital recording devices as compared to the situation in standard off-axis holography where typically several degrees for off-axis angle is employed.
A Numerical Study on the Distribution and Evolution Characteristics of an Acoustic Field in the Time Domain of a Centrifugal Pump Based on Powell Vortex Sound Theory
Authors: Guo Chang , Wang Jingying , Gao Ming
Published: November 2019

The acoustic field distribution and evolution characteristics in a time domain inside a centrifugal pump are studied. During the fluid motion process, the acoustic source and acoustic pressure are basically less than 0, and the minimum value of the two parameters is distributed near the tongue. Additionally, the concentration, break, extend, migration and reaggregation phenomena of the minimum acoustic source region exist. Specifically, as the blade passes through the tongue, the minimum acoustic source region concentrates on the tongue firstly, then extends and migrates downstream slightly with the blade motion, and aggregates again around the tongue, which results in the similar evolution characteristics of acoustic pressure. Moreover, the standard deviation (STD) of acoustic source mainly focuses near the pressure side of blade tail and volute tongue, and the maximum STD is located at the tongue. Compared with the source component induced by stretching of the vortex, the source component induced by non-uniformity of fluid kinetic energy is closer to the overall acoustic source. Take the tongue as an example, at various rotational speeds, the STD proportions of the two components are about 5% and 95%, respectively. This study discusses the generation, distribution and evolution characteristics of acoustic field, which lays a foundation to analyze the acoustic field propagation mechanism of centrifugal pumps.
A Mid-Infrared Narrowband Absorber Based on a Subwavelength Fine-Structured Silicon–Gold Metagrating
Authors: He Xin , Jie Jinliang , Yang Junbo , Han Yunxin , Zhang Sen
Published: November 2019

A subwavelength fine-structured silicon–gold metagrating was designed for realizing mid-infrared (mid-IR) narrowband absorbers. The metagrating consisted of a silicon grating on the stack of a gold film and a quartz substrate. The silicon grating consisted of two periodically arranged silicon strips in each unit cell. The numerical results reveal that perfect absorption of the traverse-magnetic (TM) polarized light at a wavelength of 4.071 μm can be achieved, with an absorption rate of ~99.2% and an absorption full-width at half-maximum (FWHM) bandwidth of ~31 nm. Thus, the proposed structure is useful for the spectral control of mid-IR signals. When used as a refractive index sensor, the structure has a measuring range of 1.0–2.0 with a quasi linear response, with a figure of merit (FOM) of ~103.
A Novel Localization Technique Using Luminous Flux
Authors: Irshad Muhammad , Liu Wenyuan , Arshad Jehangir , Sohail M. Noman , Murthy Aparna , Khokhar Maryam , Uba M Musa
Published: November 2019

As global navigation satellite system (GNNS) signals are unable to enter indoor spaces, substitute methods such as indoor localization-based visible light communication (VLC) are gaining the attention of researchers. In this paper, the systematic investigation of a VLC channel is performed for both direct and indirect line of sight (LoS) by utilizing the impulse response of indoor optical wireless channels. In order to examine the localization scenario, two light-emitting diode (LED) grid patterns are used. The received signal strength (RSS) is observed based on the positional dilution of precision (PDoP), a subset of the dilution of precision (DoP) used in global navigation satellite system (GNSS) positioning. In total, 31 × 31 possible positional tags are set for a given PDoP configuration. The values for positional error in terms of root mean square error (RMSE) and the sum of squared errors (SSE) are taken into consideration. The performance of the proposed approach is validated by simulation results according to the selected indoor space. The results show that the position accuracy enhanced is at short range by 24% by utilizing the PDoP metric. As confirmation, the modeled accuracy is compared with perceived accuracy results. This study determines the application and design of future optical wireless systems specifically for indoor localization.
Residual Power Series Technique for Simulating Fractional Bagley–Torvik Problems Emerging in Applied Physics
Authors: Alshammari Saleh , Al-Smadi Mohammed , Hashim Ishak , Alias Mohd Almie
Published: November 2019

Numerical simulation of physical issues is often performed by nonlinear modeling, which typically involves solving a set of concurrent fractional differential equations through effective approximate methods. In this paper, an analytic-numeric simulation technique, called residual power series (RPS), is proposed in obtaining the numerical solution a class of fractional Bagley–Torvik problems (FBTP) arising in a Newtonian fluid. This approach optimizes the solutions by minimizing the residual error functions that can be directly applied to generate fractional PS with a rapidly convergent rate. The RPS description is presented in detail to approximate the solution of FBTPs by highlighting all the steps necessary to implement the algorithm in addressing some test problems. The results indicate that the RPS algorithm is reliable and suitable in solving a wide range of fractional differential equations applying in physics and engineering.
Enhanced Label Noise Filtering with Multiple Voting
Authors: Guan Donghai , Hussain Maqbool , Yuan Weiwei , Khattak Asad Masood , Fahim Muhammad , Khan Wajahat Ali
Published: November 2019

Label noises exist in many applications, and their presence can degrade learning performance. Researchers usually use filters to identify and eliminate them prior to training. The ensemble learning based filter (EnFilter) is the most widely used filter. According to the voting mechanism, EnFilter is mainly divided into two types: single-voting based (SVFilter) and multiple-voting based (MVFilter). In general, MVFilter is more often preferred because multiple-voting could address the intrinsic limitations of single-voting. However, the most important unsolved issue in MVFilter is how to determine the optimal decision point (ODP). Conceptually, the decision point is a threshold value, which determines the noise detection performance. To maximize the performance of MVFilter, we propose a novel approach to compute the optimal decision point. Our approach is data driven and cost sensitive, which determines the ODP based on the given noisy training dataset and noise misrecognition cost matrix. The core idea of our approach is to estimate the mislabeled data probability distributions, based on which the expected cost of each possible decision point could be inferred. Experimental results on a set of benchmark datasets illustrate the utility of our proposed approach.
Development of a CALPHAD Thermodynamic Database for Pu-U-Fe-Ga Alloys
Authors: Moore Emily E. , Turchi Patrice E.A. , Landa Alexander , Söderlind Per , Oudot Benoit , Belof Jonathan L. , Stout Stephen A. , Perron Aurélien
Published: November 2019

The interaction of actinides and actinide alloys such as the δ-stabilized Pu-Ga alloy with iron is of interest to understand the impurity effects on phase stability. A newly developed and self-consistent CALPHAD thermodynamic database is presented which covers the elements: Pu, U, Fe, Ga across their whole composition and temperature ranges. The phase diagram and thermodynamic properties of plutonium-iron (Pu-Fe) and uranium-iron (U-Fe) systems are successfully reassessed, with emphasis on the actinide rich side. Density functional theory (DFT) calculations are performed to validate the stability of the stoichiometric (Pu,U)6Fe and (Pu,U)Fe2 compounds by computing their formation enthalpies. These data are combined to construct the Pu-U-Fe ternary phase diagram. The thermodynamic assessment of Fe-Ga is presented for the first time and application to the quaternary Pu-U-Fe-Ga system is discussed.
Recycling of Reverse Osmosis (RO) Reject Water as a Mixing Water of Calcium Sulfoaluminate (CSA) Cement for Brick Production
Authors: Lee Hwan , Jeon Dongho , Song Haemin , Sim Sung Won , Kim Dohoon , Yu Juan , Cho Kyung Hwa , Oh Jae Eun
Published: November 2019

This study explored the possibility of using reverse osmosis (RO) reject water as a mixing water for producing cementitious bricks using calcium sulfoaluminate (CSA) cement along with gypsum, and it investigated the changes in the properties of CSA cement pastes when RO reject water was used. The results were compared with those obtained using purified water and seawater. Overall, the use of RO reject water improved the cement paste’s strength. Given that the use of RO reject water very slightly affected ettringite formation but more significantly influenced the Al2O3-Fe2O3-mono (AFm) phases (i.e., monosulfate, kuzelite, and Friedel’s salt) and amorphous aluminum hydroxide (AH3), the strength improvement was likely mainly due to the formation of Friedel’s salt rather than ettringite formation. This study also demonstrated that the use of RO reject water for brick production satisfied the Korean Standards (KS) F 4004 and toxicity characteristic leaching procedure (TCLP); thus, it is recommended to use RO reject water as a mixing water to produce CSA cement bricks for use in construction.
A Novel Adaptive Gain of Optimal Sliding Mode Controller for Linear Time-Varying Systems
Authors: Phu Do Xuan , Mien Van , Choi Seung-Bok
Published: November 2019

In this study, a new optimal control law associated with the sliding mode control is developed for the linear time-varying system based on the Bolza-Meyer criterion. The salient characteristic of the controller proposed in this work is to have adjustable gains in which the gain values can be larger than 1. This leads to the enhancement of control performances with the given cost function. It is noted here that conventional optimal control laws have a constant gain of 1 or less than 1, and hence, control performances such as the convergence speed are not satisfactory. After formulating the proposed optimal control law for linear time-varying systems, several illustrative examples are adopted and control performances were evaluated to show some benefits of the proposed controller. In particular, three crucial index values of control gain index, main input control index and the state index were investigated. Among illustrative examples, one is related to vibration control problem of the vehicle seat suspension system with magnetorheological (MR) damper. This example is specially treated to evaluate the practical applicability of the proposed optimal controller by considering the measured road profiles; two different random road excitations.
A Study on Microscale Wind Simulations with a Coupled WRF–CFD Model in the Chongli Mountain Region of Hebei Province, China
Authors: Li Shaohui , Sun Xuejin , Zhang Shan , Zhao Shijun , Zhang Riwei
Published: November 2019

To ensure successful hosting of the 2022 Olympic Winter Games, a comprehensive understanding of the wind field characteristics in the Chongli Mountain region is essential. The purpose of this research was to accurately simulate the microscale wind in the Chongli Mountain region. Coupling the Weather Research and Forecasting (WRF) model with a computational fluid dynamics (CFD) model is a method for simulating the microscale wind field over complex terrain. The performance of the WRF-CFD model in the Chongli Mountain region was enhanced from two aspects. First, as WRF offers multiple physical schemes, a sensitivity analysis was performed to evaluate which scheme provided the best boundary condition for CFD. Second, to solve the problem of terrain differences between the WRF and CFD models, an improved method capable of coupling these two models is proposed. The results show that these improvements can enhance the performance of the WRF-CFD model and produce a more accurate microscale simulation of the wind field in the Chongli Mountain region.
Zhankuic Acids A, B and C from Taiwanofungus camphoratus Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells
Authors: Teng Yu-Ning , Wang Yen-Hsiang , Wu Tian-Shung , Hung Hsin-Yi , Hung Chin-Chuan
Published: November 2019

Since P-glycoprotein (P-gp)-related multidrug resistance (MDR) remains the most important unsolved problem in cancer treatment, scientists are attempting to find potential structures from natural resources. The aim of the present study was to elucidate whether the triterpenoids from Taiwanofungus camphoratus could reverse cancer MDR by influencing P-gp efflux pump. Substrates efflux assay and P-gp ATPase activity assay were conducted to reveal the molecular mechanisms of P-gp inhibition, while SRB assay, cell cycle analyses and apoptosis analyses were performed to confirm the cancer MDR modulating effects. The results indicated that Zhankuic acids A, B and C (ZA-A, ZA-B and ZA-C) impacted P-gp efflux function in competitive, noncompetitive and competitive manners, respectively. Furthermore, these triterpenoids all demonstrated inhibitory patterns on both basal P-gp ATPase activity and verapamil-stimulated ATPase activity. In terms of MDR reversal effects, ZA-A sensitized the P-gp over-expressing cell line (ABCB1/Flp-InTM-293) and MDR cancer cell line (KB/VIN) toward clinically used chemotherapeutic drugs, including doxorubicin, paclitaxel and vincristine, exhibiting the best cytotoxicity enhancing ability among investigated triterpenoids. The present study demonstrated that ZA-A, ZA-B and ZA-C, popular triterpenoids from T. camphoratus, effectively modulated the drug efflux transporter P-gp and reversed the cancer MDR issue.
Lipoprotein(a) as Orchestrator of Calcific Aortic Valve Stenosis
Authors: Schnitzler Johan G. , Ali Lubna , Groenen Anouk G. , Kaiser Yannick , Kroon Jeffrey
Published: November 2019

Aortic valve stenosis (AVS) is the most prevalent valvular heart disease in the Western World with exponentially increased incidence with age. If left untreated, the yearly mortality rates increase up to 25%. Currently, no effective pharmacological interventions have been established to treat or prevent AVS. The only treatment modality so far is surgical or transcatheter aortic valve replacement (AVR). Lipoprotein(a) [Lp(a)] has been implicated as a pivotal player in the pathophysiology of calcification of the valves. Patients with elevated levels of Lp(a) have a higher risk of hospitalization or mortality due to the presence of AVS. Multiple studies indicated Lp(a) as a likely causal and independent risk factor for AVS. This review discusses the most important findings and mechanisms related to Lp(a) and AVS in detail. During the progression of AVS, Lp(a) enters the aortic valve tissue at damaged sites of the valves. Subsequently, autotaxin converts lysophosphatidylcholine in lysophosphatidic acid (LysoPA) which in turn acts as a ligand for the LysoPA receptor. This triggers a nuclear factor-κB cascade leading to increased transcripts of interleukin 6, bone morphogenetic protein 2, and runt-related transcription factor 2. This progresses to the actual calcification of the valves through production of alkaline phosphatase and calcium depositions. Furthermore, this review briefly mentions potentially interesting therapies that may play a role in the treatment or prevention of AVS in the near future.
Nucleotide Transport and Metabolism in Diatoms
Authors: Gruber Ansgar , Haferkamp Ilka
Published: November 2019

Plastids, organelles that evolved from cyanobacteria via endosymbiosis in eukaryotes, provide carbohydrates for the formation of biomass and for mitochondrial energy production to the cell. They generate their own energy in the form of the nucleotide adenosine triphosphate (ATP). However, plastids of non-photosynthetic tissues, or during the dark, depend on external supply of ATP. A dedicated antiporter that exchanges ATP against adenosine diphosphate (ADP) plus inorganic phosphate (Pi) takes over this function in most photosynthetic eukaryotes. Additional forms of such nucleotide transporters (NTTs), with deviating activities, are found in intracellular bacteria, and, surprisingly, also in diatoms, a group of algae that acquired their plastids from other eukaryotes via one (or even several) additional endosymbioses compared to algae with primary plastids and higher plants. In this review, we summarize what is known about the nucleotide synthesis and transport pathways in diatom cells, and discuss the evolutionary implications of the presence of the additional NTTs in diatoms, as well as their applications in biotechnology.
Clerodane Diterpene Ameliorates Inflammatory Bowel Disease and Potentiates Cell Apoptosis of Colorectal Cancer
Authors: Zheng Jia-Huei , Lin Shian-Ren , Tseng Feng-Jen , Tsai May-Jywan , Lue Sheng-I , Chia Yi-Chen , Woon Mindar , Fu Yaw-Syan , Weng Ching-Feng
Published: November 2019

Inflammatory bowel disease (IBD) is general term for ulcerative colitis and Crohn’s disease, which is chronic intestinal and colorectal inflammation caused by microbial infiltration or immunocyte attack. IBD is not curable, and is highly susceptible to develop into colorectal cancer. Finding agents to alleviate these symptoms, as well as any progression of IBD, is a critical effort. This study evaluates the anti-inflammation and anti-tumor activity of 16-hydroxycleroda-3,13-dien-15,16-olide (HCD) in in vivo and in vitro assays. The result of an IBD mouse model induced using intraperitoneal chemical azoxymethane (AOM)/dextran sodium sulfate (DSS) injection showed that intraperitoneal HCD adminstration could ameliorate the inflammatory symptoms of IBD mice. In the in vitro assay, cytotoxic characteristics and retained signaling pathways of HCD treatment were analyzed by MTT assay, cell cycle analysis, and Western blotting. From cell viability determination, the IC50 of HCD in Caco-2 was significantly lower in 2.30 μM at 48 h when compared to 5-fluorouracil (5-FU) (66.79 μM). By cell cycle and Western blotting analysis, the cell death characteristics of HCD treatment in Caco-2 exhibited the involvement of extrinsic and intrinsic pathways in cell death, for which intrinsic apoptosis was predominantly activated via the reduction in growth factor signaling. These potential treatments against colon cancer demonstrate that HCD could provide a promising adjuvant as an alternative medicine in combating colorectal cancer and IBD.
Cytoproliferative and Anti-Oxidant Effects Induced by Tannic Acid in Human Embryonic Kidney (Hek-293) Cells
Authors: Perumal Pearl O. , Mhlanga Priscilla , Somboro Anou M. , Amoako Daniel G. , Khumalo Hezekiel M. , Khan Rene M.
Published: November 2019

Tannic acid (TA) portrays a myriad of beneficial properties and has forthwith achieved incessant significance for its cytoprotective qualities in traditional and modern-day medicine. However, TA displays an ambiguous nature demonstrating anti-oxidant and pro-oxidant traits, beckoning further research. Although vast literature on the anti-proliferative effects of TA on cancer cell lines exist, the effects on normal cells remain unchartered. Herein, the cytoproliferative and anti-oxidant effects induced by TA in human embryonic kidney (Hek-293) cells were investigated. Data obtained from the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay demonstrated that TA increased the cell viability and cellular proliferation rate at higher concentrations. Hoechst assay, examining proliferation marker Ki67 supported these findings. DNA fragmentation and oxidative stress-inducers were specifically noted at IC25 and IC50 treatments via biochemical assays. This alluded to TA’s pro-oxidant characteristics. However, the countervailing anti-oxidant defence mechanisms as the endogenous anti-oxidants and phase2 detoxification enzymes were significantly upregulated. Luminometry fortified the anti-oxidant capacity of TA, whereby executioner caspase-3/7 were not activated subservient to the activation of initiator caspases-8 and -9. Thus, proving that TA has anti-apoptotic traits, inter alia. Therefore, TA proved to harbour anti-oxidant, anti-apoptotic, and proliferative effects in Hek-293 cells with its partial cytotoxic responses being outweighed by its cytoprotective mechanisms.
Teachers’ Views on the Participation of Parents in the Transition of their Children from Kindergarten to Primary School
Authors: Besi Marina , Sakellariou Maria
Published: November 2019

Internationally, a great number of researchers have pointed out the significance of school–family relationship in the process of children’s transition to primary schools. However, only recently has it been a subject of research in Greece. The purpose of this particular research, which has a sample of 1602 pre-primary and primary school teachers, is to investigate teachers’ viewpoints on the role of parents in the process of their children’s transition to primary school. Data has been collected through the use of questionnaires. Statistical analysis has shown that the overwhelming majority of teachers consider cooperation with parents as necessary. They indicate that the most important factors for successful transition are parents’ level of trust in teachers, their views on schools and learning, and their support for the new situation their child experiences. As far as the most appropriate practices are concerned, almost all teachers mention updating parents at the beginning of the school year, while many suggest that parents and children visit primary schools and that common meetings of both kindergarten and primary school teachers with parents take place before school begins. It therefore seems that teachers acknowledge the role of parents in the process of transition and suggest appropriate practices for their participation.
Probabilistic Seismic Assessment of Existing Masonry Buildings
Authors: Croce Pietro , Landi Filippo , Formichi Paolo
Published: November 2019

The evaluation of seismic performance of existing masonry buildings is a critical issue in assessing the seismic vulnerability of the built environment. With this aim, non-linear static analysis is commonly used, but results are influenced significantly by the collapse criteria adopted, as well as by the assumptions about material properties and drift capacity of masonry walls. A methodology for the probabilistic assessment of the seismic risk index is proposed by means of an original non-linear pushover type algorithm developed by the authors. The main sources of uncertainties related to masonry parameters and their influence on seismic risk indices are identified by means of sensitivity analysis. Response surfaces for the seismic risk indices are thus defined through general polynomial chaos expansion in order to quantify the uncertainties in the resulting seismic risk index. Finally, a seismic performance classification is presented to help stakeholders to manage risks and define priorities for seismic retrofit. The methodology together with the outcomes is illustrated for a set of existing masonry buildings that are part of the school system in the Municipality of Florence.
Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy
Authors: Verdeil Grégory , Lawrence Toby , Schmitt-Verhulst Anne-Marie , Auphan-Anezin Nathalie
Published: November 2019

Oncogene-induced STAT3-activation is central to tumor progression by promoting cancer cell expression of pro-angiogenic and immunosuppressive factors. STAT3 is also activated in infiltrating immune cells including tumor-associated macrophages (TAM) amplifying immune suppression. Consequently, STAT3 is considered as a target for cancer therapy. However, its interplay with other STAT-family members or transcription factors such as NF-κB has to be considered in light of their concerted regulation of immune-related genes. Here, we discuss new attempts at re-educating immune suppressive tumor-associated macrophages towards a CD8 T cell supporting profile, with an emphasis on the role of STAT transcription factors on TAM functional programs. Recent clinical trials using JAK/STAT inhibitors highlighted the negative effects of these molecules on the maintenance and function of effector/memory T cells. Concerted regulation of STAT3 and STAT5 activation in CD8 T effector and memory cells has been shown to impact their tumor-specific responses including intra-tumor accumulation, long-term survival, cytotoxic activity and resistance toward tumor-derived immune suppression. Interestingly, as an escape mechanism, melanoma cells were reported to impede STAT5 nuclear translocation in both CD8 T cells and NK cells. Ours and others results will be discussed in the perspective of new developments in engineered T cell-based adoptive therapies to treat cancer patients.
Targeting Calcium Signalling in Malignant Mesothelioma
Authors: Martinotti Simona , Patrone Mauro , Moccia Francesco , Ranzato Elia
Published: November 2019

Calcium ions (Ca2+) are central in cancer development and growth, serving as a major signaling system determining the cell’s fate. Therefore, the investigation of the functional roles of ion channels in cancer development may identify novel approaches for determining tumor prognosis. Malignant mesothelioma is an aggressive cancer that develops from the serosal surface of the body, strictly related to asbestos exposure. The treatment of malignant mesothelioma is complex and the survival outcomes, rather than the overall survival data are, to date, disappointedly daunting. Nevertheless, conventional chemotherapy is almost ineffective. The alteration in the expression and/or activity of Ca2+ permeable ion channels seems to be characteristic of mesothelioma cells. In this review, we explore the involvement of the Ca2+toolkit in this disease. Moreover, the established sensitivity of some Ca2+channels to selective pharmacological modulators makes them interesting targets for mesothelioma cancer therapy.
A Review of the Potential Role of Human Cytomegalovirus (HCMV) Infections in Breast Cancer Carcinogenesis and Abnormal Immunity
Authors: Geisler Jürgen , Touma Joel , Rahbar Afsar , Söderberg-Nauclér Cecilia , Vetvik Katja
Published: November 2019

Previously recognized classical human onco-viruses can regulate complex neoplastic events, and are estimated to play a role during carcinogenesis in 15–20% of cancer cases. Although the DNA and gene products of several viruses have been found in breast tumors, none of the classical onco-viruses have definitely been linked to the initiation of breast cancer. However, recent evidence shows that human cytomegalovirus (HCMV) gene products are found in >90% of tumors and metastases of breast cancers, and their increased expression can be correlated to a more aggressive breast cancer phenotype. Supporting the active role of HCMV in breast cancer, a specific HCMV strain, HCMV-DB, was recently shown to exert oncogenic transformational activity in breast epithelial cells in vitro, and to give rise to fast-growing, triple-negative breast tumors when injected into immune deficient mice. The same observation holds true for clinical studies implying increased HCMV protein expression in triple negative breast cancer biopsies. In addition to functionally being able to hijack tumor-promoting cellular events, HCMV is known to exhibit a wide range of immunosuppressive effects, which can have radical impact on the tumor microenvironment. HCMV infected cells can avoid recognition and elimination by the immune system by orchestrating polarization of immunosuppressive type II macrophages, preventing antigen presentation, by expressing T cell inhibitory molecules, and possibly, by the induction of regulatory T (Treg) cell responses. These actions would be especially deleterious for the antigenic activation and proliferation of tumor specific CD8+ cytotoxic T lymphocytes (CTLs), whose effector functions have recently been targeted by successful, experimental immunotherapy protocols. The recognition of alternative causes and drivers of breast cancer is a pivotal research topic for the development of diagnostics and novel, effective preventive and therapeutic strategies targeting both tumor cells and their microenvironments.
Lanthanum Exchanged Keggin Structured Heteropoly Compounds for Biodiesel Production
Authors: Al-Shammari Badriah , A. Alsulami Qana , Narasimharao Katabathini
Published: November 2019

La-exchanged 12-tungstophosphoric acid (LaxTPA) and 12-molybdophosphoric acid (LaxMPA) salts (x = 0.25, 0.50, 0.75 and 1.00) were prepared via an ion exchange method. The physico-chemical characteristics of the materials were analyzed by using elemental analysis, X-ray diffraction (XRD), Fourier transformed infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), N2-physical adsorption, X-ray photoelectron spectroscopy (XPS), and acidity-basicity measurements. The results indicated that La was introduced into the secondary structure of heteropolyacid (HPA) and have not influenced the primary structure, which effectively improved the surface area and pore size. Acidity-basicity studies indicated that incorporation of La resulted in a decrease in the number of acid sites and an increase in the number of basic sites. The catalytic activity of samples was studied in transesterification of glyceryl tributyrate with methanol and LaxTPA samples which exhibited high activity compared to LaxMPA samples due to having more active basic sites and a larger surface area. Calcined LaxTPA samples showed excellent stability, outstanding recyclability, and high activity for one pot transesterification and esterification processes. This outcome was attributed to the presence of balanced acidic and basic sites.
Fabrication of Monolithic Catalysts: Comparison of the Traditional and the Novel Green Methods
Authors: Wang Zexuan , Zhao Kunfeng , Xiao Bei , Gao Peng , He Dannong , Cai Ting , Yuan Jing
Published: November 2019

Monolithic catalysts have great industrial application prospects compared to powdered catalysts due to their low pressure drop, the high efficiency of mass and heat transfer, and recyclability. Deposition of active phases on the monolithic carriers dramatically increases the utilization rate and has been attracting continuous attention. In this paper, we reviewed the traditional (impregnation, coating, and spraying) and novel (hydrothermal and electrodeposition) strategies of surface deposition integration, analyzed the advantages and disadvantages of both ways, and then prospected the possible directions for future development of integration technologies.
PC1/3 KD Macrophages Exhibit Resistance to the Inhibitory Effect of IL-10 and a Higher TLR4 Activation Rate, Leading to an Anti-Tumoral Phenotype
Authors: Rodet Franck , Capuz Alice , Ozcan Bilgehan-Aybike , Le Beillan Rémy , Raffo-Romero Antonella , Kobeissy Firas , Duhamel Marie , Salzet Michel
Published: November 2019

During tumorigenesis, macrophages are recruited by tumors and orientated towards a pro-tumoral phenotype. One of the main anti-tumoral immunotherapy consists of their re-polarization in an anti-tumoral phenotype. We have demonstrated that the inhibition of proprotein convertase 1/3 combined with TLR4 activation in macrophages is a promising strategy. These macrophages display pro-inflammatory and anti-tumoral phenotypes. A hallmark is a stronger activation of the pro-inflammatory NFKB pathway. We believe that this can be explained by a modification of TLR4 expression at the cell surface or MYD88 cleavage since it exhibits a potential cleavage site for proprotein convertases. We tested these hypotheses through immunofluorescence and Western blot experiments. A proteomics study was also performed to test the sensitivity of these macrophages to IL-10. We demonstrated that these macrophages treated with LPS showed a quicker re-expression of TLR4 at the cell surface. The level of MYD88 was also higher when TLR4 was internalized. Moreover, these macrophages were resistant to the pro-tumoral effect of IL-10 and still produced pro-inflammatory factors. This established that the sensitivity to anti-inflammatory molecules and the length of TLR4 desensitization were reduced in these macrophages. Therefore, during antitumoral immunotherapy, a repeated stimulation of TLR4 may reactivate PC1/3 inhibited macrophages even in an anti-inflammatory environment.
MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation
Authors: Costa Viviana , Carina Valeria , Raimondi Lavinia , De Luca Angela , Bellavia Daniele , Conigliaro Alice , Salamanna Francesca , Alessandro Riccardo , Fini Milena , Giavaresi Gianluca
Published: November 2019

Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used. In our recent studies, we identified two miRNAs as regulators of hMSCs osteoblast differentiation driving hypoxia signaling and cytoskeletal reorganization. Other signalings involved in this process are epithelial to mesenchymal transition (EMT) and epidermal growth factor receptor (EGFR) signalings through the regulation of Yes-associated protein (YAP)/PDZ-binding motif (TAZ) expression. In the current study, we investigated the role of miR-33a family as a (i) modulator of YAP/TAZ expression and (ii) a regulator of EGFR signaling during osteoblast commitments. Starting from the observation on hMSCs and primary osteoblast cell lines (Nh-Ost) in which EMT genes and miR-33a displayed a specific expression, we performed a gain and loss of function study with miR-33a-5p and 3p on hMSCs cells and Nh-Ost. After 24 h of transfections, we evaluated the modulation of EMT and osteoblast genes expression by qRT-PCR, Western blot, and Osteoimage assays. Through bioinformatic analysis, we identified YAP as the putative target of miR-33a-3p. Its role was investigated by gain and loss of function studies with miR-33a-3p on hMSCs; qRT-PCR and Western blot analyses were also carried out. Finally, the possible role of EGFR signaling in YAP/TAZ modulation by miR-33a-3p expression was evaluated. Human MSCs were treated with EGF-2 and EGFR inhibitor for different time points, and qRT-PCR and Western blot analyses were performed. The above-mentioned methods revealed a balance between miR-33a-5p and miR-33a-3p expression during hMSCs osteoblast differentiation. The human MSCs phenotype was maintained by miR-33a-5p, while the maintenance of the osteoblast phenotype in the Nh-Ost cell model was permitted by miR-33a-3p expression, which regulated YAP/TAZ through the modulation of EGFR signaling. The inhibition of EGFR blocked the effects of miR-33a-3p on YAP/TAZ modulation, favoring the maintenance of hMSCs in a committed phenotype. A new possible personalized therapeutic approach to bone regeneration was discussed, which might be mediated by customizing delivery of miR-33a in simultaneously targeting EGFR and YAP signaling with combined use of drugs.
Environmental Barrier Coatings Made by Different Thermal Spray Technologies
Authors: Vaßen Robert , Bakan Emine , Gatzen Caren , Kim Seongwong , Mack Daniel Emil , Guillon Olivier
Published: November 2019

Environmental barrier coatings (EBCs) are essential to protect ceramic matrix composites against water vapor recession in typical gas turbine environments. Both oxide and non-oxide-based ceramic matrix composites (CMCs) need such coatings as they show only a limited stability. As the thermal expansion coefficients are quite different between the two CMCs, the suitable EBC materials for both applications are different. In the paper examples of EBCs for both types of CMCs are presented. In case of EBCs for oxide-based CMCs, the limited strength of the CMC leads to damage of the surface if standard grit-blasting techniques are used. Only in the case of oxide-based CMCs different processes as laser ablation have been used to optimize the surface topography. Another result for many EBCs for oxide-based CMC is the possibility to deposit them by standard atmospheric plasma spraying (APS) as crystalline coatings. Hence, in case of these coatings only the APS process will be described. For the EBCs for non-oxide CMCs the state-of-the-art materials are rare earth or yttrium silicates. Here the major challenge is to obtain dense and crystalline coatings. While for the Y2SiO5 a promising microstructure could be obtained by a heat-treatment of an APS coating, this was not the case for Yb2Si2O7. Here also other thermal spray processes as high velocity oxygen fuel (HVOF), suspension plasma spraying (SPS), and very low-pressure plasma spraying (VLPPS) are used and the results described mainly with respect to crystallinity and porosity.
TDPAC Studies of Local Defects and Phenomena in Ferroics and Multiferroics
Authors: Schell Juliana , Marschick Georg
Published: November 2019

We provide an overview of time-differential perturbed angular correlation (TDPAC) measurements of ferroic and multiferroic materials. Here, we explore chalcogenide spinels, lead titanate, lead zirconate, and bismuth ferrite, describing the use of TDPAC experiments to probe the physics of localized defects and the various mechanisms that govern electronic and magnetic interactions, the coupling of the associated degrees of freedom, and the structural, charge, and orbital correlations for these materials.
Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications
Authors: Tepale Nancy , Fernández-Escamilla Víctor V. A. , Carreon-Alvarez Clara , González-Coronel Valeria J. , Luna-Flores Adan , Carreon-Alvarez Alejandra , Aguilar Jacobo
Published: November 2019

The fundamental aspects of the manufacturing of gold nanoparticles (AuNPs) are discussed in this review. In particular, attention is devoted to the development of a simple and versatile method for the preparation of these nanoparticles. Eco-friendly synthetic routes, such as wet chemistry and biosynthesis with the aid of polymers, are of particular interest. Polymers can act as reducing and/or capping agents, or as soft templates leading to hybrid nanomaterials. This methodology allows control of the synthesis and stability of nanomaterials with novel properties. Thus, this review focus on a fundamental study of AuNPs properties and different techniques to characterize them, e.g., Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), UV-Visible spectroscopy, Dynamic Light Scattering (DLS), X-Ray Diffraction (XRD), X-Ray Photoelectron Spectroscopy, Small-angle X-Ray Scattering (SAXS), and rheology. Recently, AuNPs obtained by “green” synthesis have been applied in catalysis, in medicine, and as antibacterials, sensors, among others.
Overall Survival and Adjuvant Therapy in Women with Ovarian Carcinosarcoma: A Single-Institution Experience
Authors: Nizam Aaron , Bustamante Bethany , Shan Weiwei , Shih Karin K. , Whyte Jill S. , Sakaris Antoinette , dos Santos Lisa , Frimer Marina , Menzin Andrew W. , Truskinovsky Alexander , Goldberg Gary L.
Published: November 2019

Background: Carcinosarcoma of the ovary (CSO) is a rare and aggressive variant of ovarian cancer. Due to the rare nature of the disease there is insufficient evidence to make recommendations regarding standard management and overall prognosis. Methods: An Institutional Review Board-approved study identified all our patients with CSO between January 2011 and May 2018. Demographic and outcome measures were abstracted from the medical records and tumor board files. Cox proportional hazard models, log rank tests, and comparisons of means were used to calculate significance (p < 0.05). Results: 27 women with CSO were identified. The median age at diagnosis was 65 years (range 48–91). Five women (18%) presented with early stage disease (Stage I or II) and 22 patients (82%) presented with late stage III or IV disease. Twenty patients (74%) received intravenous platinum-based combination chemotherapy. Seven patients did not receive chemotherapy during their treatment course. The median overall survival was 23 months (range 2–68 months). Overall survival was not significantly worsened by the stage of disease at diagnosis. There was no difference in survival based on the age at diagnosis, tobacco status or ethnicity (p > 0.05). Conclusion: This is one of the largest single institution experiences with CSO. The majority of our patients presented with advanced stage disease and received adjuvant platinum-based chemotherapy after cytoreductive surgery. The median overall survival of 23 months was not affected by the stage of the disease. The optimal management of this rare disease needs further study with collaborative, prospective multi-institutional trials.
An Overview of Teaching Physics for Undergraduates in Engineering Environments
Authors: Zalewski Janusz , Novak Gregor , Carlson Randall E.
Published: November 2019

This paper is an overview of approaches to teaching physics courses delivered to students of engineering disciplines. It addresses, first, the history of teaching physics to engineering students starting in the early 20th century, then reviews the main issues presented and discussed over the last decade in a series of conferences on Physics Teaching in Engineering Education (PTEE). Finally, this paper discusses more contemporary views on the subject, including the latest technologies and new methodologies. It is not a critical review of teaching physics to engineering students, but rather a summary of various views and approaches over the span of the entire century. The common denominator of the study is the relevance to the competency-based approach: how the papers focus on teaching engineers the principles of physics in a manner that contributes to success in their professional careers.
Closing the Wearable Gap—Part IV: 3D Motion Capture Cameras Versus Soft Robotic Sensors Comparison of Gait Movement Assessment
Authors: Saucier David , Davarzani Samaneh , Turner Alana , Luczak Tony , Nguyen Phuoc , Carroll Will , Burch V Reuben F. , Ball John E. , Smith Brian K. , Chander Harish , Knight Adam , Prabhu Raj. K.
Published: November 2019

The purpose of this study was to use 3D motion capture and stretchable soft robotic sensors (SRS) to collect foot-ankle movement on participants performing walking gait cycles on flat and sloped surfaces. The primary aim was to assess differences between 3D motion capture and a new SRS-based wearable solution. Given the complex nature of using a linear solution to accurately quantify the movement of triaxial joints during a dynamic gait movement, 20 participants performing multiple walking trials were measured. The participant gait data was then upscaled (for the SRS), time-aligned (based on right heel strikes), and smoothed using filtering methods. A multivariate linear model was developed to assess goodness-of-fit based on mean absolute error (MAE; 1.54), root mean square error (RMSE; 1.96), and absolute R2 (R2; 0.854). Two and three SRS combinations were evaluated to determine if similar fit scores could be achieved using fewer sensors. Inversion (based on MAE and RMSE) and plantar flexion (based on R2) sensor removal provided second-best fit scores. Given that the scores indicate a high level of fit, with further development, an SRS-based wearable solution has the potential to measure motion during gait- based tasks with the accuracy of a 3D motion capture system.
Uniform Sampling Methodology to Construct Projection Matrices for Angle-of-Arrival Estimation Applications
Authors: Al-Sadoon Mohammed A. G. , de Ree Marcus , Abd-Alhameed Raed A. , Excell Peter S.
Published: November 2019

This manuscript firstly proposes a reduced size, low-complexity Angle of Arrival (AoA) approach, called Reduced Uniform Projection Matrix (RUPM). The RUPM method applies a Uniform Sampling Matrix (USM) criterion to sample certain columns from the obtained covariance matrix in order to efficiently find the directions of the incident signals on an antenna array. The USM methodology is applied to reduce the dependency between the adjacent sampled columns within a covariance matrix; then, the sampled matrix is used to construct the projection matrix. The size of the obtained projection matrix is reduced to minimise the computational complexity in the searching grid stage. A theoretical analysis is presented to demonstrate that the USM methodology can increase the Degrees of Freedom (DOFs) with the same aperture size and number of sampled columns compared to the classical sampling criterion. Then, a polynomial root is constructed as an alternative efficient computational solution of the UPM method in a one-dimensional (1D) array spectrum peak searching problem. It is found that this distribution increases the number of produced nulls and enhances noise immunity. The advantage of the RUPM method is that it is appropriate to apply for any array configuration while the Root-UPM offers better estimation accuracy with less execution time under a uniform linear array condition. A computer simulation based on various scenarios is performed to demonstrate the theoretical claims. The proposed direction-finding methods are compared with several AoA methods in terms of the required execution time, Signal-to-Noise Ratio (SNR) and different numbers of data measurements. The results verify that the new methods can achieve significantly better performance with reduced computational demands.