Expert consensus and current landscape of NUT carcinoma: A comprehensive strategy from diagnosis to treatment
Authors: Ye Zhuomiao , Li Xin , Xie Fei , Deng Chao , Yang Dan , Li Hongle , Lu Yuanzhi , Mao Zhenbin , Meng Qingwei , Wang Lidong , Wang Zhe , Xing Jinliang , Bai Chong , Bian Zhimin , Boffano Paolo , Brower Steven , Chen Rui , Chen Wantao , Deng Jinhai , Deng Xinpei , Ding Chunming , Duan Jianchun , Duan Song , Duzgunes Nejat , Franco Pierfrancesco , Fu Guobin , Guo Longmei , Guo Ye , Han Ruiqin , Hao Ling , He Lang , He Yayi , Hu Xiaotong , Jia Junmei , Jiang Yanfang , Jin Weilin , Kairemo Kalevi , Kamal Mohamed , Keller Evan T. , Lai Rensheng , Li Chao , Li Jun , Li Lifeng , Li Qingxia , Li Wenbin , Li Xuening , Li Yang , Li Yongsheng , Li Yu , Lindström Mikael S. , Liu Xiaodong , Liu Yan , Liu Yanqing , Liu Zengjun , Lopes Jose Manuel , Lu Hongyang , Luo Xiangwen , Ma Wenping , Meng Hongxue , Min Anjie , Moya Amancio Carnero , Papavassiliou Athanasios G. , Pan Xi , Peng Min , Popper Helmut H. , Qiu Lixin , Qu Di , Schönthal Axel H. , Shelat Vishal , Shi Yi , Shtil Alexander , Siddique Hifzur R , Song Yang , Su Haichuan , Tang Min , Wang Mengyuan , Wang Qiming , Wang Shubin , Wei Bing , Wu Dawei , Wu Longxiang , Xu Liangbi , Yan Yubo , Yang Nong , Yang Zihuan , Yi Zongbi , Yu Songtao , Zhang Heng , Zhang Hongmei , Zhang Lijuan , Zhao Jianfu , Zhao Zheng , Zheng Shaoquan , Zhou Chengzhi , Zhou Pu , Zhou Qin , Zhu Guodong , Yan Qin , Zhang Minghui , Yin Mingzhu 
Published: December 2024

Nuclear protein of the testis (NUT) carcinoma is a rare and highly aggressive malignancy characterized by the rearrangement of the NUT midline carcinoma family member 1 (NUTM1) gene. Nevertheless, standardized strategies for its diagnosis and treatment remain unavailable, underscoring the need for expert consensus. To address this gap, we conducted a systematic review to gather comprehensive information on NUT carcinoma from five databases: PubMed, Web of Science, Embase, Cochrane Library, and Ovid Medline. This expert consensus was collaboratively developed by a team of international multidisciplinary experts, in partnership with the NUT Carcinoma Diagnosis Working Group of the Chinese Anti-Cancer Association&rsquo;s Oncogene Diagnosis Professional Committee. This working group comprises medical oncologists, radiation oncologists, surgical oncologists, pathologists, nurses, molecular biologists, statisticians, and bioinformatics specialists. A systematic review, based on data from 526 patients across 199 articles, was conducted to comprehensively explore various characteristics, including demographic features (e.g., patient gender, distribution regions, and age), tumor-node-metastasis (TNM) classification stage, clinical symptoms, tumor size, metastatic patterns, immunohistochemical (IHC) findings, treatment modalities, prognosis-related information, and NUTM1 fusion partners. We have developed an expert consensus on diagnosing and treating NUT carcinoma using a multidisciplinary approach. The guideline provides eight recommendations, addressing epidemiological characteristics, clinical and imaging manifestations, pathological findings, IHC features, molecular mechanisms and subtypes, prognosis, diagnosis, and treatment strategies for NUT carcinoma. Furthermore, an international platform has been established to disseminate NUT carcinoma knowledge and patient recruitment, providing patients and healthcare providers access to NUT carcinoma-related information and updates on clinical trial recruitment.