bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Ransum yang Mengandung Azolla microphylla terhadap Indeks Kuning, Indeks Putih dan Haugh Unit Telur Ayam
Authors: Ramadhan Rahmad Fani , Aulia Nazilla , Rusmana Denny , Mansyur Mansyur
Published: April 2024

ABSTRAK. Penelitian ini bertujuan untuk mengetahui pengaruh ransum yang mengandung azolla (Azolla microphylla) terhadap indeks kuning telur, indeks putih telur dan haugh unit telur ayam. Azolla merupakan tanaman paku air yang pertumbuhan cepat dan dapat dijadikan bahan pakan alternatif untuk ayam petelur. Penelitian menggunakan 48 ekor ayam petelur strain ISA Brown berumur 54 minggu di Fakultas Peternakan, Universitas Padjadjaran. Penelitian ini dilakukan secara eksperimental dengan metode Rancangan Acak Lengkap (RAL) dengan 4 perlakuan (P0= ransum tanpa azolla; P1= ransum dengan 5% azolla; P2= ransum dengan 10% azolla; dan P3= ransum dengan 15% azolla) dan 6 ulangan. Hasil penelitian menunjukkan bahwa ransum yang mengandung azolla berpengaruh tidak nyata (P0,05) terhadap indeks putih telur, indeks kuning telur dan haugh unit telur. Penggunaan azolla sampai taraf 15% menghasilkan nilai yang sama terhadap indeks kuning telur, indeks putih telur dan haugh unit telur ayam.  (Growth and production of Indigofera zollingeriana in post-sand mining land with addition Fertilizer and mycorrhizae)  ABSTRACT. This study aimed to determine the effect of a ration containing azolla (Azolla microphylla) on the yolk index, albumen index, and haugh unit of layers. Azolla is a water fern that grows fast and can be used as an alternative feed ingredient for laying hens. The study used 48 laying hens of the ISA Brown strain aged 54 weeks at the Faculty of Animal Husbandry, Padjadjaran University. This research was conducted experimentally using a completely randomized design (CRD) with 4 treatments and 6 replications for each treatment, P0 (ration without azolla), P1 (ration with 5% azolla), P2 (ration with 10% azolla), and P3 (ration with 15% azolla). The results showed that the ratio containing Azolla had no significant effect (P0.05) on the yolk index, albumen index, and haugh unit of layers. The use of Azolla up to 15% level produces the same value on the yolk index, albumen index, and haugh unit of layers.
Effect of Cleaning and Storing on Hatching Time and Hatching Weight of Mojosari Alabio (MA) Crossbred Duck Eggs
Authors: Ramon Erpan , Efendi Zul , Nurhaita Nurhaita , Hidayat Taufik , Permadi Selma Noor , Firison Jhon , Ishak Andi
Published: April 2024

ABSTRACT. The hatchability of duck eggs is influenced by handling before the eggs are placed in the incubator. The research was conducted in Bengkulu City from September to October 2021 to determine the effect of cleaning and storage before incubation of MA duck eggs from crossing Mojosari males and Alabio females on hatching time and hatching weight. The research was conducted using a completely randomized factorial design (4x6). The first factor is cleaning with three treatments, namely control or no cleaning (L0); cleaning using two ml/l disinfectant (L1), cleaning using warm water (L2), and cleaning with distilled water (L3). The second factor is the storage time, namely P0= 0 days, P1= 1 day, P2= 2 days, P3= 3 days, P4= 4 days, and P5= 5 days. There were eight repetitions of each treatment. According to the study, there was an average of 96% egg fertility and 87.45% hatchability. There was no interaction effect (P0.05) between cleaning and storage on egg hatching time. Cleaning with disinfectant or distilled water shortened the incubation time. Cleaning with distilled water without storage resulted in the highest hatching weight of duck eggs (L3P0) but was not significantly different from treatments L0P1, L1P0, L1P3, L1P5, L2P0, L3P0, and L3P3. Hatching weight is influenced by the interaction effect between egg cleaning and storage.  Pengaruh pembersihan dan penyimpanan terhadap waktu penetasan dan berat tetas telur itik persilangan Mojosari Alabio (MA)  ABSTRAK. Daya tetas telur itik dipengaruhi oleh penanganan sebelum telur dimasukkan ke inkubator. Penelitian dilakukan di Kota Bengkulu pada Bulan September sampai Bulan Oktober 2021 dengan tujuan untuk mengetahui pengaruh pembersihan dan penyimpanan sebelum inkubasi telur itik MA hasil persilangan jantan Mojosari dan betina Alabio terhadap waktu tetas dan bobot tetas. Penelitian dilakukan dengan menggunakan rancangan acak lengkap faktorial (4x6). Faktor pertama pembersihan dengan tiga perlakuan yaitu kontrol atau tidak ada pembersihan (L0); pembersihan menggunakan disinfektan 2 ml/l (L1), pembersihan menggunakan air hangat (L2), dan pembersihan dengan akuades (L3). Faktor kedua adalah lama penyimpanan yaitu P0= 0 hari, P1= 1 hari, P2= 2 hari, P3= 3 hari, P4= 4 hari, dan P5= 5 hari. Setiap perlakuan diulang sebanyak delapan kali. Hasil penelitian menunjukkan bahwa fertilitas telur rata-rata 96% dengan daya tetas 87,45%. Tidak terdapat pengaruh interaksi (P0,05) antara pembersihan dan penyimpanan terhadap waktu penetasan telur, namun pembersihan dengan disinfektan atau dengan aquades mempersingkat waktu inkubasi. Pembersihan dengan akuades tanpa penyimpanan menghasilkan bobot tetas telur itik tertinggi (L3P0) namun tidak berbeda nyata dengan perlakuan L0P1, L1P0, L1P3, L1P5, L2P0, L3P0, dan L3P3. Bobot tetas dipengaruhi oleh efek interaksi antara pembersihan dan penyimpanan telur.
An Exploratory Study of Beef Cattle Farming Systems: A Comparative Analysis of Cut and Carry in Java vs. the Pastoral System in Sumba Island, Indonesia
Authors: Setianto Novie Andri , Sodiq Akhmad , Sumarmono Juni , Kii Wilhelmus Yape , Widiyanti Rahayu , Haryoko Imbang
Published: April 2024

ABSTRACT. This study aims to explore the differences between beef cattle farming systems in Java and Sumba. The research was conducted using a survey method in three districts, two districts in Central Java and one district in Sumba Island, NTT. Data analysis used a descriptive qualitative approach, with the CATWOE Analysis framework to determine the perspectives of stakeholders involved in the beef cattle farming business system. Beef cattle farming in Java has been characterized by a cut and carry system, while in Sumba with a pasture grazing system. The research shows that the main purpose of cattle rearing in Java is to generate income for the family, so more and more are running enlargement and fattening businesses. Cattle rearing in Sumba is prioritized for savings for traditional purposes. Farmers in Sumba predominantly breed cattle without additional feed to save on maintenance costs. Farmers are still faced with the problem of unfairness in pricing. The study concluded that farmers show adaptive ability in allocating their resources to obtain profits. Differences in farming paradigms need to be considered in the preparation of livestock development programs.  (Studi eksploratif pada sistem pemeliharaan sapi potong: analisis komparatif pada sistem cut and carry di jawa dengan sistem penggembalaan pastura di pulau Sumba, Indonesia)  ABSTRAK. Peternakan sapi potong di Jawa selama ini dicirikan dengan cut and carry sistem, sedangkan di Sumba dengan sistem penggembalaan di pastura. Penelitian ini bertujuan untuk melakukan eksplorasi lebih mendalam tentang perbedaan sistem usaha peternakan sapi potong di Jawa dengan di Sumba. Penelitian dilakukan dengan metode survey di tiga kabupaten, dua kabupaten di Jawa Tengah dan satu kabupaten di Pulau Sumba, NTT. Analisis data menggunakan pendekatan deskriptif kualitatif, dengan kerangka CATWOE Analysis untuk mengetahui perspektif dari para stakeholders yang terlibat dalam sistem usaha peternakan sapi potong. Penelitian menunjukkan bahwa tujuan utama pemeliharaan sapi di Jawa adalah untuk menghasilkan pendapatan untuk keluarga, sehingga semakin banyak yang lebih menjalankan usaha pembesaran dan penggemukan. Pemeliharaan sapi di Sumba lebih diutamakan untuk tabungan untuk keperluan adat. Peternak di Sumba didominasi pembiakan sapi tanpa tambahan pakan untuk menghemat biaya pemeliharaan. Peternak masih dihadapkan pada permasalahan ketidakadilan dalam penentuan harga. Penelitian menyimpulkan bahwa peternak menunjukkan kemampuan adaptif dalam mengalokasikan sumber daya yang dimiliki untuk memperoleh keuntungan. Perbedaan paradigma beternak perlu untuk diperhatikan dalam penyusunan program pembangunan peternakan.
Detection of ‘Candidatus Phytoplasma mali’ and ‘Candidatus Phytoplasma prunorum’ in apple trees
Authors: Meral Harun , Ekemen Muhammet , Ulubaş Serçe Çiğdem
Published: April 2024

The apple orchards in Niğde, Turkiye were surveyed for ‘Candidatus Phytoplasma mali’ associated with apple proliferation disease, and the suspicious samples were tested by PCR-RFLP methods. A comprehensive study was conducted which included sampling from a total of 19 orchards from four different districts. The samples were collected according to the major symptoms of phytoplasma disease which were foliar reddening, witches’ brooms, leaf rosettes, yellowing, longer peduncles and development of undersized fruits. It was determined that six out of 62 plant samples were infected with pyhtoplasma. Also, two out of six infected samples were determined as infected by ‘Ca. P. mali’ and unexpectedly four out of six infected samples were determined as infected by ‘Ca. P. prunorum’ associated with European Stone Fruit Yellows disease. Even if the incidence of the disease (9.7%) was low, the characterized phytoplasmas were considered as a significant potential threat for these locations.

Key words: PCR-RFLP Survey, Niğde, Apple proliferation, European stone fruit yellows
Evaluating Students’ Perception of Visual Mathematics in Secondary Geometry Education: A Mixed Methods Investigation
Authors:   Higher Colleges of Technology, United Arab Emirates, Wardat Yousef
Published: April 2024

The present study aimed to assess the perspectives of female secondary school students on the integration of visual mathematics in engineering lessons. Employing a mixed-methods approach, specifically a convergent parallel design, qualitative data were gathered through observations and interviews (both individual and focus groups), while quantitative data were collected using a questionnaire. Video clips of engineering unit lessons were utilized as educational materials. The study included 135 female students in the first year of secondary school, with 74 participating in qualitative segments, divided into focus groups and individual interviews. SPSS was employed for quantitative data analysis, calculating means and standard deviations, while thematic analysis was applied for qualitative data. Key findings indicate that visual displays significantly contributed to enhancing female students’ comprehension of mathematical concepts, facilitating the understanding of inter-concept relationships and their application in engineering. The incorporation of visual aids also positively impacted the mathematical coherence abilities of female students, establishing connections between mathematics, other subjects, and real-life situations. Furthermore, visual presentations in engineering topics were found to improve female students’ attitudes toward learning mathematics, fostering increased self-confidence and enjoyment in learning various engineering subjects. Recommendations from the study include the need for training both male and female teachers in designing effective visual presentations for teaching mathematical concepts.
Assessment of factors related to treatment failure and recurrence of superficial dermatophytosis
Authors: Ibrahim Evana , Mowla Rafiqul , Faroque Abu S. M. O. , Shahrin Sabrina , Kulsum Umme
Published: April 2024

Background: Superficial dermatophytosis, commonly known as ringworm, is a fungal infection of the skin, hair, or nails caused by dermatophytes, primarily belonging to the genera Trichophyton, Microsporum, and Epidermophyton. Despite being a superficial infection, the rising incidence of treatment failure and recurrence has become a matter of concern in recent years.
Methods: This prospective observational study, conducted at the department of dermatology and venereology of Chittagong Medical College Hospital, aimed to investigate the epidemiological factors associated with treatment failure and recurrent cases of superficial dermatophytosis. The study spanned from March 2022 to February 2023, involving 249 participants diagnosed with Tinea corporis, Tinea cruris, Tinea facies, or Tinea pedis. Factors such as excessive sweating, use of warm water, clothing habits, sharing practices, and topical corticosteroid application were analyzed.
Results: The most common age group affected was 21-30 years, with a male preponderance (1.6:1). Excessive sweating, wearing water-soaked garments, and sharing towels were prevalent among participants. After 4 weeks of treatment, 81.5% achieved complete cure, but 52.7% of these cases experienced a recurrence within the subsequent 4 weeks. Multivariate analysis identified sharing towels, family history of dermatophytosis, and past topical steroid use as significant risk factors for treatment failure/recurrence.
Conclusions: The study emphasizes the importance of linen (sharing towels) in the transmission of dermatophytosis and highlights the increased risk associated with a family history of the condition. Additionally, the injudicious use of topical steroids emerged as a significant factor contributing to treatment failure and recurrence.
A prospective, randomized double-blind, placebo-controlled study for safety and efficacy of SesZen-Bio™: a proprietary Sesbania grandiflora extract in managing hair and scalp health in healthy adults
Authors: Upadhyay Ratna , Gadani Mihir C. , Badak Sneha , Patel Nayan , Merja Apeksha , Patel Maheshvari
Published: April 2024

Background: Hair loss, a common multifactorial condition affecting both genders, results from causes like extrinsic factors (pollution, sun, humidity, and temperature), nutritional variation, or intrinsic factors such as ageing, heredity, hormonal and medical conditions. Some of the damages caused by these factors can be effectively managed with multivitamins, minerals, antioxidant natural products. Present study assessed use of standardised herbal Sesbania grandiflora extract for improving hair density, hair thickness and scalp health along with a serum biomarker to establish the probable mechanism of action.
Methods: The study was approved by the ethics committee and was conducted as per standard national regulations. 51 randomized subjects (mean age: 39.40±5.80 years) received either test-treatment or placebo for consecutive 56 days. Instrumental assessments included a phototrichogram to assess hair density, thickness, and scalp condition.
Results: SesZen-BioTM which is derived from Sesbania grandiflora extracts showed an improvement in hair density, hair thickness and ferritin in 8 weeks of usage suggesting it stimulates the keratin production which resulted in improved follicle growth. By day 56 of usage, hair density and thickness improved by 58.92±28.69 cm2 and 3.68±2.69 μm respectively from baseline (both p<0.0001) in the treatment group. This indicates towards 25% improvement in hair density, 16.94% in hair thickness and almost 72% volunteers indicated an improvement in hair health along with 27% increase in serum ferritin.
Conclusions: Sesbania grandiflora extract -SesZen-Bio® showed beneficial nutritional effects on research subjects, proving its usefulness as a well-tolerated and efficient daily supplement to improve hair health.
Accuracy of foot length measurement for gestational age assessment in neonates: a prospective observational study in Central India
Authors: Singhal Asmita , Agrawal Avyact , Parihar Rashmi , Sahu Nency , Upadhyay Jaya
Published: April 2024

Background: Gestational age (GA) is a critical-factors in the decision making and predicting mortality and morbidities of neonates. In low resource settings where affordability and availability of first trimester scan is limited, assessment is often done by postnatal methods like expanded new Ballard score (ENBS) which are often clinical skill dependent and complex. Hence, there is a need of a simple and cost-effective method which can be readily adopted by frontline health care workers at periphery. One such method is assessment of foot length (FL).
Methods: This prospective cross-sectional study was conducted in the level 3 NICU of Central India over a period of 18 months. Included neonates were assessed for GA by measuring FL by vernier calliper within 48 hours of birth and its validity was tested against ENBS as reference standard. Other anthropometric measurements like birth weight, head circumference and length were obtained within 48 hours of birth.
Results: Total 700 neonates were included in the study. For, determining preterm newborn, the potential cut-off of FL of ≤6.86 cm, with a sensitivity of 94.6% and specificity of 73.8%. The area under ROC (receiver operating characteristic) curve is 0.92.
Conclusions: FL measurement is a cost-effective and time-saving simple intervention that can facilitate early identification of preterm newborns as well as help in initiating timely interventions and hence improving neonatal outcomes in resource-poor settings.
Antenatal care quality assessment methods in India: a systematic review
Authors: Kataria Priya , Kumar Naresh , Singh Mahendra
Published: April 2024

Antenatal care (ANC) is one of the most important pillars in improving maternal health. There is a considerable gap between the coverage of ANC and quality of ANC in India. Although monitoring the number of visits or contacts remains important, the WHO ANC guidelines’ focus is on the quality and content of the care received. We did a review of literature regarding the quality of ANC assessment in India from 2017 to 2023. The literature review was done by two researchers independently on electronic databases: PubMed/Medline, PubMed central, Embase and ScienceDirect, to search the methods that are used to assess the quality of ANC in India. We included the studies that have done assessment of the quality of ANC with specific ‘content’ and ‘criteria’ to define quality ANC (QANC). There are two dimensions for assessing ANC quality. ANC Visits (their number and time of registration) and the services received during ANC visits. We found three types of approaches to ANC quality assessment: 1) making categories depending on content of ANC visits and/or number of ANC visits; 2) scoring system where score is assigned to each service and a particular cut off is set to be called QANC and 3) combination of both (using scores to form categories). The literature on quality assessment of ANC is scarce. There is a need for a standard quality of care method and terminology to assess the quality of ANC that can be applied throughout the country.
Knowledge, attitude and perceived barriers to telemedicine among medical professionals: a cross sectional study
Authors: Jossy Preeti Elizabeth , Nandini Parvathi , Nair Parvathy R. , S. Nimisha J. , S. Niveditha V. , Rahul Arya
Published: April 2024

Background: Telemedicine, an evolving technology in India's healthcare sector, offers promising avenues for improving healthcare accessibility and delivery. Its successful implementation relies on several factors, including the comprehension of its concepts, skill acquisition, attitude toward technology, and conducive work environments among healthcare professionals. Despite the pressing need for enhanced healthcare in developing countries like India, telemedicine remains more advanced in developed nations. The objective of this study was to evaluate the knowledge, attitude, and perceived barriers to telemedicine among medical professionals at government medical college Trivandrum and KIMS health Trivandrum.
Methods: A cross-sectional survey involving 150 medical professionals across various departments was conducted using a structured questionnaire via the Kobo toolbox, an online survey tool. The collected data were analyzed to assess the understanding of telemedicine, attitudes toward its adoption, and barriers encountered by respondents.
Results: The analysis revealed that while a commendable 35.3% of respondents exhibited a good understanding of telemedicine, the majority 64.7% lacked sufficient knowledge in this domain. However, there was a positive disposition towards telemedicine adoption, with 64.7% displaying strong positive attitudes, 24.7% expressing moderate attitudes, and 10.7% indicating lower inclinations. Notably, human resource availability emerged as the most prevalent barrier, while sustainable practices were cited least frequently.
Conclusions: While many medical professionals showed support for telemedicine, their knowledge was limited, and the study identified multiple barriers to its adoption. Urgent action is needed to narrow the disparity between telemedicine's potential and its actual use in India's healthcare system.
The impact of electronic prescribing systems on clinical pharmacy practice
Authors: Alzahrani Turki Ibrahim , Binsaad Jaman Saad , Almasabi Abdullah Ahmed , Alharthi Faeyz Musleh , Alqarni Abdullah Salem , Albaqami Salman Nasser , Alqahtani Muhannad Saeed , Aljabry Iman
Published: April 2024

This review explores the impact of electronic prescribing (e-prescribing) systems on clinical pharmacy practice, highlighting the potential benefits and challenges associated with their use. Medication errors, a significant concern within healthcare settings, have been shown to decrease with the adoption of e-prescribing, offering a promising tool to enhance patient safety and reduce adverse drug events. However, the transition from traditional handwritten prescriptions to electronic methods introduces new challenges, including the emergence of new types of errors, such as incorrect drug selection, and potential increases in mortality rates, as observed in pediatric patient. Furthermore, it discusses the limited exploration of e-prescribing in primary care and community pharmacy settings, areas that require further investigation to fully understand the benefits and burdens of e-prescribing use. By examining barriers related to person, tasks, environment, tools and technologies, and organizational factors, this review emphasizes the importance of considering various aspects that influence the efficacy and safety of e-prescribing systems. The findings suggest a critical need for incorporating human factors principles in the design and evaluation of these systems to ensure they effectively support clinical pharmacy practice and enhance patient care.
Advances in stem cell therapy for articular cartilage lesions: clinical evidence and future directions: a systematic review
Authors: Miranda Suárez Kevin , Pesantez Zea Claudia Anabel , Fabara Vera Mateo Daniel , Pasquel Rodríguez Bryan Steven , Zambrano Garces Andrea Janet , Velastegui Jijón Erick Santiago , Romo Quintana Angel Eduardo , Bautista Suárez Katherine Lizeth
Published: April 2024

The significance of articular cartilage, an essential connective tissue, cannot be overstated in relation to joint health and functionality. Nevertheless, the human body might have adverse effects due to traumatic incidents, degenerative conditions, or repetitive stress, resulting in the manifestation of pain, inflammation, and impaired functionality. The primary objective of this study is to assess the effectiveness of stem cell therapy in the treatment of articular cartilage damage such as lesions. The systematic review was conducted adhering to the PRISMA principles. Boolean logic is employed in the search technique to integrate phrases pertaining to stem cell therapy, articular cartilage diseases, and biological processes. The research employs a range of databases and medical subject headings (MeSH) in order to facilitate a thorough examination. The stem cell therapy in the treatment of articular cartilage lesions has great potential. It enhances management and treatment outcomes for individuals afflicted with cartilage abnormalities. It is beneficial particularly those diagnosed with osteoarthritis (OA). Encouraging outcomes, such as alleviation of pain and improvement in functionality have been reported. Additional investigation is required to enhance therapy regimens, encompassing cell dosage, delivery techniques, and supplementary medicines. The use of stem cell therapies necessitates the imperative collaboration among researchers, doctors and regulatory agencies.
Efecto del bloqueo de bombas de eflujo en el tratamiento antimicrobiano en cepas con multirresistencia tipo BLEE de origen clínico en Boyacá, Colombia
Authors: Angarita-Merchán Maritza , Di Filippo-Iriarte Giselle , Mora-Moreno Diana Patricia , Ferrebuz-Cardozo Atilio Junior
Published: April 2024

Introducción: El aumento de bacterias resistentes a múltiples fármacos destaca la necesidad de mejorar las terapias antimicrobianas. Las bombas de eflujo, que reducen la concentración de antimicrobianos en las bacterias, son clave en la resistencia, mecanismos que disminuyen la concentración de antimicrobianos en las bacterias, contribuyendo a la resistencia. Objetivo: evaluar el efecto del inhibidor de bombas de eflujo Phenylalanine-arginine β-naphthylamide sobre la resistencia bacteriana a los antibióticos ceftazidima, clortetraciclina, ciprofloxacina, ceftriaxona, ampicilina y gentamicina en bacilos gram negativos con múltiples genes de BLEE aisladas. Materiales y Métodos: se realizó un estudio experimental con el propósito de analizar los aislamientos de bacilos gram negativos multirresistentes asociados a infecciones procedentes de una Institución prestadora de servicios de salud de Boyacá, para esto, a partir de 81 aislamientos bacterianos se detectaron genes de resistencia antibiótico en 70 cepas mediante reacción en cadena de la polimerasa convencional y secuenciación tipo Sanger. Resultados: en los 70 aislamientos analizados se evidenció la presencia de determinantes genéticos de resistencia a antibióticos betalactámicos como: blaTEM1, blaSHV1, blaSHV2 y blaCTM-X, con predominancia del gen blaSHV. Conclusiones: el ensayo de interacción mostró qué en cepas multirresistentes, la terapia conjunta con inhibidores de bombas de expulsión puede ser una alternativa para el tratamiento, sin embargo, debido a la gran diversidad de las bombas de eflujo, se deben evaluar otras familias de inhibidores para identificar los que sean eficientes en un mayor número de cepas.
Peasant family: food unites and feeds
Authors: Orozco-Castillo Liliana , Betancurth-Loaiza Diana Paola , Giraldo-Osorio Alexandra
Published: April 2024

Introduction: Nutrition is a sociocultural process of international relevance with little research development from a cultural perspective. Objective: To interpret the perceptions related to nutrition in peasant families of a municipality in the rural area of the department of Caldas (Colombia). Methodology: Interpretive ethnography, with purposive sampling. seven peasant families participated through participant observation and ethnographic interview. Spiral analysis was performed with the support of Atlas ti software. Results: The category “With food we take care of ourselves, we nourish ourselves, we unite” emerged, supported by three subcategories. Conclusions: Food consumption has several implicit and heterogeneous meanings, specifically nutritional intake, illness and as a demonstration of affection.
Adaptación de un modelo de evaluación para intervenciones complejas en salud pública
Authors: García-Zapata Lina María , Soto-Chaquir Mercy , Galarza-Iglesias Ana Milena , Morales-Viana Liliana Cristina
Published: April 2024

Introducción: las intervenciones en salud pública buscan aportar al mejoramiento de las condiciones de salud individual o de una comunidad en escenarios reales. No obstante, los diferentes modelos evaluativos que existen actualmente se centran en conocer su efectividad, impacto o resultados y dejan un vacío en la comprensión acerca del funcionamiento de la intervención, para quiénes y en qué circunstancias funcionan o no. Se requiere un modelo evaluativo que permita generar evidencia acerca de las explicaciones causales y los resultados asociados con la activación de mecanismos en condiciones complejas, tanto en el contexto como en su desarrollo. Objetivo: adaptar un modelo evaluativo para intervenciones complejas en salud pública que incorpore las categorías de la evaluación realista de contexto, mecanismo y resultados en este tipo de intervenciones. Metodología: se realizó un estudio cualitativo exploratorio de consenso formal, con técnica de grupo nominal, vinculando a 15 técnicos en salud pública y 10 expertos en evaluación e investigación evaluativa a partir de 3 talleres de discusión, y se siguió un proceso iterativo de 3 encuentros participativos hasta llegar al consenso para la consolidación del modelo evaluativo en salud pública. Resultados: este modelo de evaluación incorpora características de las intervenciones en salud pública e integra elementos del contexto, mecanismo y resultado, para facilitar la comprensión de la efectividad de una intervención y poder determinar lo que funciona, o no, para quiénes y en qué circunstancias. Conclusiones: esta adaptación de modelo evaluativo aporta información relevante para la toma de decisiones a partir de una evaluación de intervenciones en contextos reales.
Determinants of E-wallet DANA Usage in Generation Z: Proving the UTAUT-2 Model
Authors: Nursafitri Andrini , Chaidir Taufiq
Published: April 2024

Abstrak:
Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor yang mempengaruhi penerimaan generasi Z terhadap e-wallet DANA di Kota Mataram dengan memanfaatkan model extended UTAUT atau UTAUT-2 beserta persepsi kepercayaan dan keamanan. menggunakan pendekatan kuantitatif dengan metode survei kuesioner yang disebarkan dalam bentuk digital dan manual. Responden penelitian ini adalah pengguna e-wallet DANA yang berjumlah 120 orang, berdomisili di Kota Mataram, berusia 13-28 tahun. Teknik analisis yang digunakan peneliti adalah (PLS-SEM). Hasil penelitian, tidak terdapat pengaruh yang signifikan antara nilai harga, kebiasaan, motivasi hedonis, kondisi yang memfasilitasi, ekspektasi kinerja, ekspektasi upaya, atau nilai harga terhadap niat Generasi Z untuk mengadopsi e-wallet DANA sebagai sistem pembayaran digital. Sementara itu, niat generasi Z untuk menggunakan e-wallet DANA sangat dipengaruhi oleh persepsi keamanan, kepercayaan, dan pengaruh sosial. Kemudian, niat berperilaku generasi Z berdampak besar pada penggunaan e-wallet DANA atau tidak. Implikasinya bagi penyedia layanan e-wallet DANA adalah memberikan rekomendasi strategi dan perencanaan dalam meningkatkan niat generasi z untuk mengadopsi sistem pembayaran e-wallet DANA.
LA LUTTE CONTRE LA PAUVRETE AU SENEGAL : STRATEGIES DE FINANCEMENT POUR UN AVENIR EQUITABLE
Authors: Mansour M.  Gueye , Sosa Lopez Dr. Atahualpa
Published: April 2024

Résumé :
Objectif :
La lutte contre la pauvreté au Sénégal reste un défi majeur malgré des avancées économiques et sociales. Cette étude vise à proposer une approche complète pour progresser vers un avenir plus inclusif et prospère pour tous les citoyens sénégalais.
Méthode :
Nous avons analysé les principaux facteurs de pauvreté, comme le faible niveau d'éducation, les disparités socio-économiques, la gouvernance déficiente et la dépendance aux industries extractives. Les contraintes budgétaires, la base fiscale étroite, la fraude fiscale et les secousses économiques régionales ont également été examinées. Notre approche intégrée propose le renforcement du système fiscal, la stimulation de l'investissement privé, la mobilisation de fonds internationaux, l'amélioration de l'éducation et de la formation, et la promotion de l'inclusion financière, avec une collaboration entre gouvernement, secteur privé, société civile et communauté internationale.
Résultats :
Une mise en œuvre efficace pourrait améliorer l'accès aux services de base, renforcer les capacités locales, promouvoir des politiques inclusives et soutenir la création d'emplois. En encourageant le dialogue et la coopération, le Sénégal peut surmonter les obstacles et construire une société plus juste.
Conclusion :
Une approche globale impliquant le renforcement des systèmes économiques, sociaux et politiques, avec une collaboration étroite entre les acteurs, est essentielle pour combattre la pauvreté au Sénégal. Cela ouvrirait la voie à un avenir où tous bénéficient d'une meilleure qualité de vie et d'opportunités équitables.
Some theorems on the class M-A(n*) operators on Hilbert space
Authors: Al-shakarchi Shaymaa
Published: April 2024

This work proves that if T belong to the class M-A(n*) operator and S* is an invertible operator belonging to the same class such that TX=XS, then T*X=XS*, where X is a Hilbert-Schmidt operator.
Synthesis, spectroscopic characterization, crystal structure and DNA docking studies of a new trans-platinum saccharinate complex containing aqua and dimethyl sulfoxide ligands
Authors: İçsel Yılmaz Ceyda
Published: April 2024

A new trans-platinum complex, trans-[Pt(sac)2(H2O)(DMSO)] (sac= saccharinate; DMSO= dimethyl sulfoxide), was synthesized and characterized by elemental analysis, UV, FTIR, NMR spectroscopy and X-ray single-crystal diffraction. In the mononuclear complex, the platinum(II) cation was coordinated by two N-coordinated sac ligands in the trans position, the sulfur atom of the DMSO ligand, and an aqua ligand, forming a distorted square planar coordination geometry. The interaction of the platinum(II) complex with DNA was studied using molecular docking. The complex successively docked into the minor groove of DNA via intermolecular hydrogen bonds with the adenine, cytosine, and guanine bases.
In Vitro Inhibitory Effects of Some Antiviral, Antidiabetic, and Non-Steroidal Anti-Inflammatory Drug Active Compounds on α-Glucosidase and Myeloperoxidase Activities
Authors: Yaşar Boztaş Fatma , Tunalı Sevim
Published: April 2024

In recent decades, interest in enzyme inhibition, such as myeloperoxidase (MPO) and glycosidases, has dramatically increased, mainly because these enzymes play a vital role in many biological processes. Based on the biological potential associated with these enzymes, instead of several glycosidase and myeloperoxidase (MPO) inhibitors that have been developed, there are not enough studies on the inhibition effects of widely used types of antivirals (aciclovir, tenofovir), oral antidiabetics (glibenclamide, glibornuride, glurenorm, met-formin), and non-steroidal anti-inflammatory drugs (NSAIDs) active substances (benzydamine HCl, diclofenac, indomethacin, ketorolac tromethamine, paracetamol, salicylic acid) today. For that reason, the aim of our study is to investigate the inhibition effects of these 12 different drug active substances on α-glucosidase and MPO activities. According to the obtained results, the screened drug active substances acyclovir, glibornuride, and paracetamol inhibited α-glucosidase with the lowest IC50 value, while similarly low values for MPO were found by tenofavir, glurenorm, and indomethacin. In our study, we can suggest that these active pharmaceu-tical ingredients may contribute to the pharmaceutical industry due to their inhibitory effects on α-glucosidase and MPO in vitro.
Conversor CA-CC trifásico bidirecional e isolado de único estágio para aplicação em carregadores veiculares multifuncionais
Authors: Kan Rafael Felipe Van , Ramos Leonardo Adriano , Mezaroba Marcello , Rech Cassiano
Published: April 2024

Este artigo apresenta a análise e operação de um conversor CA-CC trifásico, bidirecional e isolado em alta frequência, de único estágio com correção do fator de potência, destinado para aplicação como carregador embarcado de baterias de veículos elétricos. Este conversor pode operar nos modos Grid-to-Vehicle (G2V) e Vehicle-to-Grid (V2G). No lado primário tem-se um conversor boost trifásico intercalado (interleaving) com modulação PWM senoidal para conexão com a rede elétrica, e na saída um barramento CC com ponto médio. O lado secundário é composto por uma topologia em ponte completa com modulação PWM convencional de razão cíclica de 50%. A transferência de potência do lado primário ao secundário é realizada por meio da técnica de defasamento angular (phase-shift), a mesma utilizada em conversores Dual-Active Bridge (DAB). Devido a defasagem natural do sistema trifásico, é possível obter transferência de potência constante, de reduzida ondulação, por meio do controle do defasamento angular também constante. Os princípios de operação do conversor são apresentados e demonstrados por análises qualitativas e quantitativas. Resultados experimentais de um protótipo de potência de 3 kW, tensão de entrada da rede elétrica de 127 V/60 Hz, tensão de saída de 300 V e frequência de comutação de 50 kHz são apresentados. Em conformidade com as análises, o protótipo doconversor apresentou fator de potência de 0,997, potência transferida entre primário e secundário constante e de baixa ondulação e dinâmica satisfatória e rápida durante ensaios de inversão do fluxo de potência.
Controladores PID com desempenho otimizado aplicados a conversores boost com incertezas paramétricas na carga
Authors: Viaro Robert Uiliam Marin , Borin Lucas Cielo , Medke Renan , De Araújo Olinto César Bassi , Tambara Rodrigo Varella , Mattos Everson , Montagner Vinícius Foletto
Published: April 2024

A principal motivação para este trabalho é a possibilidade de melhorar o projeto de controladores proporcionais-integrais-derivativos aplicado ao conversor boost, com incertezas paramétricas na carga, por meio de meta-heurísticas. Neste sentido, propõe-se aqui um novo procedimento para sintonia automática off-line destes controladores aplicados à regulação de tensão de conversores CC-CC do tipo boost com carga pertencente a um intervalo de incertezas. Um algoritmo de otimização por enxame de partículas é utilizado para evoluir os ganhos do controlador de forma a minimizar um erro médio quadrático da tensão de saída, respeitando limites pré-estabelecidos para margens de fase e de ganho, de frequência de cruzamento, e também para sobressinal e tempo de acomodação das respostas transitórias para variações de carga. O controlador otimizado pelo procedimento proposto fornece respostas superiores quando comparado a controladores largamente utilizados, projetados apenas para uma carga nominal. Resultados experimentais em um protótipo de 50 W, com o controle implementado em um processador digital de sinais de baixo custo, confirmam a viabilidade prática.
Passive interfacial cooling sparks a major leap in solar-driven water and power cogeneration
Authors: Li Shengyou , Zhao Kaiying , Shin Eun Ae , Kim Gwanho , Zan Guangtao
Published: April 2024

Freshwater and electricity are foundational to human civilization's advancement. Yet, the duel against their scarcity intensifies as modernization progresses. Solar energy, hailed for its inexhaustibility and environmental friendliness, has emerged as a promising ally in generating both freshwater and electricity. Despite significant interest and strides in solar cogeneration, the challenge of enhancing both freshwater and electricity outputs concurrently has stymied broader application.
Antiviral activity of lactoferrin: a focus on hepatitis C chronic
Authors: Viana Emille Tejo , Gonçalves Thainá Ferreira , Oliveira Carlos Rocha
Published: April 2024

Introduction: The Hepatitis C virus (HCV) is one of the main causes of chronic liver disease in the world, and despite having a treatment with sustained virologic response rate, this therapy is not resolutive for all patients. Objectives: To carry out a literature review on the action of bovine lactoferrin (bLf) on chronic hepatitis C to find evidence of its antiviral effect for a possible treatment associated with conventional therapy. Methodology: 49 articles were found according to the descriptors “lactoferrin” “immunotherapy” “chronic hepatitis C” in the pre-selected databases and seven were chosen according to the inclusion and exclusion criteria for writing the review in question. Results: The benefit of bLF use was related to the reduction of serum HCV RNA levels (1106 kIU/ml to 612 kIU/ml), plasma 8-isoprostane (8.6 ± 3.7 to 6.9 ± 2.1 pg/ml) and alanine aminotransferase (ALT) values (85 ± 80 to 63 ± 55 IU/l). Conclusion: The studies showed a possible antiviral effect of bovine lactoferrin that should be explored, through further studies, for adjuvant use in patients with chronic hepatitis C who do not show complete efficacy with the pre-established treatment for the disease.
Post-COVID Syndrome: Persistence of Symptoms and Risk Factors (Longitudinal Observational Study)
Authors: Agafonova T. Yu. , Elovikova N. N. , Bronnikova O. V. , Golyadinets D. A.
Published: April 2024

The aim - studying the dynamics of symptoms of post-COVID syndrome (depending on the results of depending on the results of the polymerase chain reaction for SARS-CoV-2) and the factors influencing it.Materials and methods. A study is a cohort, observational longitudinal. Stage I: snapshot analysis of medical records of patients with COVID-19 disease history 12 months. (questionnaire for post-COVID syndrome, blood tests). Stage II: questionnaire repeat, disease history — 24 months. There were test (positive polymerase chain reaction, 138 people) and control (negative polymerase chain reaction, 87 people) groups. Statistical analysis: package Statistica 13.5.0.17.Results. 1 year after COVID-19, the frequency of manifestations of post-COVID syndrome was (test vs control group): asthenia 63 % vs 64 %, decreased quality of life 59 % vs 56 %, respiratory syndrome 60 % vs 49 %, arthralgia 55 % vs 49 %, cardiac syndrome 47 % vs 46 % (the difference is not significant); symptoms are associated with female gender (r=0.231- 0.379), severity of COVID-19 (r=0.187-0.425), D-dimer (r=0.244-0.328). After 2 years, the frequency of symptoms was: asthenia 43 % vs 45 %, cardiac symptoms 23 % vs 15 %, respiratory symptoms 18 % vs 22 %, skin manifestations 8 % vs 12 %, decreased quality of life 7 % vs 9 %, the difference is not significant; symptoms are associated with age (r=0.208-0.402). During two years, symptoms have been correlating with platelets (r=-0.322-0.403), liver enzymes (r=0.216-0.298), blood lipids (r=0.188-0.257).Conclusions. The severity of post-COVID syndrome does not depend on the results of the polymerase chain reaction for SARS-CoV-2. The frequency of cardiac and respiratory syndromes after 2 years decreases by 2-3 times; quality of life improves. Asthenia is the most long-term syndrome. Risk factors for post-COVID syndrome during the 1st year — severity of COVID-19, female gender, D-dimer level; from the 2nd year — age. For two years after COVID-19, monitoring of liver enzymes, lipids, and platelets is required.
Efficacy and its Predictors of Antiviral Therapy with Nucleos(T)Ide Analogs in Patients with Chronic Hepatitis B
Authors: Nguyen T. H. , Ilchenko L. Yu. , Melnikova L. I. , Kyuregyan K. K. , Gordeychuk I. V.
Published: April 2024

Background: Antiviral therapy with nucleos(t)ide analogs for chronic hepatitis B is aimed at preventing disease progression and the development of complications. However, current therapies do not allow elimination of hepatitis B virus, and long-term treatment is required to maintain clinical effect in most patients. In this regard, the study of associated factors with the efficacy of antiviral therapy of nucleos(t)ide analogs is actual.Aim: To evaluate efficacy and identify predictors of response to antiviral therapy with nucleos(t)ide analogs in patients with chronic hepatitis B.Materials and methods: This retrospective-prospective observational study included 71 patients with chronic hepatitis B who received nucleos(t)ide analogs at the Center for Diagnosis and Treatment of Chronic Viral Hepatitis from 2008 to 2023. The efficacy of antiviral therapy with nucleos(t)ide analogs was evaluated after 24, 48, and 96 weeks of drug intake. The prognostic factors associated with obtaining a virologic response after one year of antiviral therapy and with achieving a significant decrease in liver density by transient elastometry were examined. Results: The virologic and biochemical response rate increased as antiviral therapy continued, and after 96 weeks of taking nucleos(t)ide analogs was 92.6 %. Baseline viral load level was an independent prognostic factor for achieving aviremia after 48 weeks of antiviral therapy (p=0.022). HBsAg clearance was observed in 2 (2.8 %) patients, HBeAg clearance — in 5 HBeAg-positive patients. On nucleos(t)ide analogs treatment there was a significant decrease of liver fibrosis measured by transient elastometry, and a high level of transient elastometry at the beginning of antiviral therapy is a factor associated with a significant decrease in liver density (by 25 % or more) (p=0.022).Conclusion: Antiviral therapy with nucleos(t)ide analogs has demonstrated high efficacy in suppressing hepatitis B virus replication, normalizing aminotransferase activity, and reducing liver fibrosis. Baseline viral load and transient elastometry levels are the most important prognostic factors associated with the efficacy of antiviral therapy with nucleos(t)ide analogs.
Assessment of Clinical and Diagnostic Indicators of Cardiovascular Toxicity in Patients with Non-Hodgkin’s Lymphomas in the Course of Programmatic Antitumor Therapy
Authors: Gimatdinova G. R. , Danilova O. E. , Davydkin I. L. , Rubanenko O. A. , Stepanova T. Y.
Published: April 2024

Цель исследования. Изучить ассоциацию клинико-диагностических показателей кардиоваскулярной токсичности у пациентов с неходжкинскими лимфомами, находящихся в процессе программной противоопухолевой иммунохимиотерапии.Материалы и методы. Проспективно было отобрано 72 пациента с подтвержденным диагнозом «индолентная неходжкинская лимфома», которым показано проведение противоопухолевого лечения по схеме R-CHOP. Пациенты были обследованы в два визита: V1 — на старте и V2 — после 6 курсов терапии. В процессе наблюдения пациенты были поделены на 2 группы: основную — с признаками сердечно-сосудистой токсичности (21 пациент, 16 (76,2 %) мужчин, средний возраст 55,2 (9,8) лет) и контрольную — без нее (51 пациент, 21 (41,2 %) мужчин, средний возраст 53,7(13,6) лет. Кардиоваскулярная токсичность верифицировалась на основании сочетания жалоб с изменениями в сократительной способности миокарда: снижения фракции выброса левого желудочка >10 % от исходного уровня или в абсолютном выражении менее, чем 53 % и/или снижения продольной систолической деформации левого желудочка >12 % от исходного уровня.Результаты. По окончанию основного лечения в обеих группах наблюдения отмечено статистически значимое увеличение QTc. Значимо менялось значение глобальной продольной систолической деформации левого желудочка у пациентов основной группы при одномоментном отсутствии ключевых сдвигов в отношении фракции выброса левого желудочка. Наиболее чувствительным лабораторным показателем кардиоваскулярной токсичности оказался NTproBNP, концентрация которого статистически значимо увеличивалась у основной группы пациентов.Заключение. Расширение минимальной диагностической панели и комплексный подход к верификации кардиоваскулярной токсичности у пациентов онкогематологического профиля, получающих потенциально токсичную для сердечно-сосудистой системы терапию, позволит существенно улучшить показатели эффективности работы ключевых служб здравоохранения, снизить финансовые расходы на нивелирование осложнений и повысить качество жизни пациентов.