bluuebunny/crossref_metadata_2025 huggingface dataset:
Acidente vascular cerebral em adulto jovem: análise dos registros do sistema de informação hospitalar
Authors: Mateus Benetti Lutieri , Machado Bueno André Luis
Published: September 2019

Trata-se de um estudo ecológico, retrospectivo, das internações por Acidente Vascular Cerebral (AVC) em adultos jovens, cujo objetivo foi descrever o perfil epidemiológico desses eventos. Os dados são oriundos do Sistema de Informação Hospitalar (SIH) registrado no período de 2013 a 2017. O estudo se justifica pelo número crescente dos casos de internação por AVC nessa faixa etária no Rio Grande do Sul - RS. O aumento da doença em adultos jovens tem despertado o interesse da comunidade acadêmica, uma vez que a sua ocorrência representa, negativamente, um fator de impacto individual e socioeconômico. Entre os resultados destaca-se que o sexo feminino apresentou a maior prevalência de AVC, com 58,49%. Indivíduos de origem preta/parda apresentaram os maiores percentuais de acometimento e a doença não se comporta de forma sazonal. A análise cartográfica sugere vulnerabilidade na acessibilidade à recursos de saúde em diversas áreas do RS.
Why are individuals with autism spectrum disorder at risk group for unhealthy weight?
Authors: Trambacz-Oleszak Sylwia
Published: September 2019

Several studies have indicated that the prevalence of unhealthy body weight in individuals with autism spectrum disorder (ASD) is high. It is unclear whether factors related to the weight status of children and adolescents with ASD are the same or different from factors associated with the weight status of typically developing children (TDC). The objective of this review was to identify key factors associated with the higher rates of unhealthy weight observed in individuals with ASD and create a structural model, which could be used for future autism intervention research. This review summarizes the current state of knowledge on the genetic basis of obesity in ASD, special treatment (behavioral and medical, including diet and psychotropic medications), psychological (depression and anxiety) as well as somatic comorbid disorders such as feeding problems, sensory processing disorders, gastrointestinal problems and sleep disorders, physical activity and sedentary behaviors, loneliness and social isolation, and family functioning (maternal depression and stress).
Analysis of Higher Education Indicators Coherency in Central and Eastern Europe
Authors: Andrejević Panić Andrea , Lozanov-Crvenković Zagorka
Published: September 2019

Background: Higher education has the main role in generating innovative activity in knowledge-based economies. Therefore, the efficiency of the higher education sector reflects the alignment of the higher education policy with government expenditure. However, countries in Central and Eastern Europe (CEE region) have been struggling with national budget optimisation, which can cause fiscal stress and thus affect the efficiency of higher education.

Objectives: The main objective is to examine mutual interaction of higher education indicators, through formulating financial models that connect performance and financial indicators.

Methods/Approach: A total of 4 higher education indicators were analysed and observed in the time period of 10 years in selected CEE countries. The statistical analysis was based on panel data models.

Results: The main result of the paper is the analysis of coherency of selected higher education indicators in selected CEE countries in order to establish functional links between government expenditure and efficiency through formulating financial models.

Conclusions: Formulated financial models can predict the behaviour of selected performance indicators, depending on financial indicators. Therefore, the obtained models can contribute to the efficient allocation of funds and comprehensive macro-level decision making assessments in higher education policy reforms.
Foreign-Versus Domestic-Owned firms in the Predicament ‘Cui bono?’
Authors: Apostolov Mico , Scagnelli Simone Domenico
Published: September 2019

Background: This article examines the productivity of domestic firms in the case of the foreign ownership.

Objectives: Foreign direct investments affect the competitive competences of domestic firms; thus, the objective is to see the way foreign ownership drives the growth of domestic firms.

Methods/Approach: The study uses standard models to analyse productivity; they are applied to data sets of Macedonia, a Southeast European economy, and it is concluded that foreign ownership has a major role in domestic firms’ restructuring processes increasing their productivity.

Results: Surely, the results support the principal notion that the augmented presence of foreign firms is to influence the restructuring and business activity of domestic companies positively.

Conclusions: Our analysis verifies that foreign ownership has influenced the overall economy and particularly domestic-owned firms with the constant increase in employment and especially direct export.
Brexit and new perspectives of an unconventional way of Eurozone revival
Authors: Kyriazis Nikolaos A. , Economou Emmanouil M. L.
Published: September 2019

In the aftermath of the UK referendum on June 23rd, 2016 that resulted in a sonorous negative decision regarding the willingness of the British people to remain in the EU, a significant number of alarming questions have emerged. Although Europe should have forged in crises, nowadays, many compromises have to be made in order to maintain the European construction as intact as possible. The question we attempt to answer is whether a new phase of unconventional monetary policy in the form of QE would be appropriate to lessen the threat of an upcoming crisis. This is why we examine Eurozone QE perspectives through the prism of the new EU era without the UK in order to highlight the pros and cons of the historical Brexit decision. As new rounds of unconventional monetary policy are believed to be essential for supporting the weaker countries in the European south, perspectives of non-conventional success could alter and optimal policies be substantially reformulated subject to the newly-arising constraints. Based on the main scenarios about the UK’s relations to the European Union in the near future, we estimate how a new round of non-conventional measures could affect the Britons as well as the European citizens. Moreover, we try to assess the viability of each of these outcomes through the spectrum of a monetary-driven decision-making.
Disinflationary Spillovers from The Euro Area into the Countries of Southeastern Europe
Authors: Ramadani Gani , Pandiloski Predrag
Published: September 2019

We analyse the determinants of the inflation trends in ten Southeast European (SEE) countries. Global cost-related factors and euro area inflation developments play an important role in explaining inflation dynamics in SEE countries. Changes in world food and energy prices, together with related changes in administered prices, similarly contribute to these trends. In general, we show that disinflationary spillovers from the euro area have been an important factor for fixed exchange rate regime countries, especially those with more trade exchange with countries in the euro area. Furthermore, our heterogeneity analysis shows that countries with less rigid exchange rate regimes but with relatively high exposure of trade exchange to the euro area (EA) market appear to be susceptible to inflation spillovers from the euro area. Moreover, nominal effective exchange rate plays an important role in inflation process in SEE countries, particularly in floating regime countries. In line with several recent findings about flattening of the Phillips curve in many economies across the world, cyclical unemployment does not appear to be significant in our sample. We conclude with some policy implications of our results.
Practice and Challenge of International Peer Review: A Case Study of Research Evaluation of CAS Centers for Excellence
Authors: Xu Fang , Li Xiaoxuan
Published: September 2019

Purpose

The main goal of this paper is to show that international peer review can work in China’s context with satisfactory outcomes. Moreover, this paper also provides a reference for the practice of science and technology management.

Design/methodology/approach

This paper starts with a discussion of two critical questions about the significance and design of international peer review. A case study of international peer review of CAS Centers for Excellence is further analyzed.

Findings

International peer review may provide a solution to address the problem of quantitative oriented research evaluation in China. The case study of research evaluation of CAS Centers for Excellence shows that it is possible and feasible to conduct an international peer review in China’s context. When applying this approach to other scenarios, there are still many issues to consider including individualized design of international peer review combined with practical demands, and further improvement of theories and methods of international peer review.

Research limitation

1) Only the case of international peer review of CAS Centers for Excellence is analyzed; 2) A relatively small number of respondents were surveyed in the questionnaire.

Practical implications

The work presented in this study can be used as a reference for future studies.

Originality/value

Currently, there are no similarly detailed studies exploring the significance and methodology of international peer review in China.
Methods and Practices for Institutional Benchmarking based on Research Impact and Competitiveness: A Case Study of ShanghaiTech University
Authors: Chang Jiang , Liu Jianhua
Published: September 2019

Purpose

To develop and test a mission-oriented and multi-dimensional benchmarking method for a small scale university aiming for internationally first-class basic research.

Design/methodology/approach

An individualized evidence-based assessment scheme was employed to benchmark ShanghaiTech University against selected top research institutions, focusing on research impact and competitiveness at the institutional and disciplinary levels. Topic maps opposing ShanghaiTech and corresponding top institutions were produced for the main research disciplines of ShanghaiTech. This provides opportunities for further exploration of strengths and weakness.

Findings

This study establishes a preliminary framework for assessing the mission of the university. It further provides assessment principles, assessment questions, and indicators. Analytical methods and data sources were tested and proved to be applicable and efficient.

Research limitations

To better fit the selective research focuses of this university, its schema of research disciplines needs to be re-organized and benchmarking targets should include disciplinary top institutions and not necessarily those universities leading overall rankings. Current reliance on research articles and certain databases may neglect important research output types.

Practical implications

This study provides a working framework and practical methods for mission-oriented, individual, and multi-dimensional benchmarking that ShanghaiTech decided to use for periodical assessments. It also offers a working reference for other institutions to adapt. Further needs are identified so that ShanghaiTech can tackle them for future benchmarking.

Originality/value

This is an effort to develop a mission-oriented, individually designed, systematically structured, and multi-dimensional assessment methodology which differs from often used composite indices.
Establishment of renal failure models by laparoscopy in bama pigs which underwent partial nephrectomy and radical contralateral nephrectomy
Authors: Liu Hai-Feng , Li Hui , Bai Ge , Zhang Qian-Zhen , Xiang-Gao  , Liu Tao , Wang Hong-Bin
Published: September 2019

Introduction

The miniature pig possesses unmatched advantages as an animal model because of its high homology with humans. Our experiment aimed to build a chronic renal failure (CRF) model in pigs via laparoscopy.

Material and Methods

Laparoscopic surgery was performed twice to build a CRF model. The first surgery was a left partial nephrectomy and the second was a right radical nephrectomy. Pigs were grouped by the total renal tissue to be resected: ⅔, ¾ or ⅚. Physiological parameters (rectal temperature and heart rate), haematological parameters (WBC and RBC) and renal function (serum creatinine – CR and blood urea nitrogen – BUN) were measured preoperatively and every week postoperatively.

Results

After renal resection the pigs manifested chronic renal failure. Heart rate and body temperature declined to varying degrees over 12 postoperative weeks. No significant difference was observed between the different groups. The result of renal function tests found that postoperative serum CR and BUN in all groups were continuously elevated, and the level of serum CR at two weeks post procedure differed very significantly from its preoperative value (P < 0.05). BUN was significantly elevated at one week (P < 0.05). The renal function decreased significantly faster in the ⅚ group than in the other two groups. The trend of renal function change was similar among groups, but progress was slower in the ⅔ and ¾ groups.

Conclusion

⅚ kidney resection was the optimal miniature pig model of CRF.
Amorphus globosus foetuses in Polish Holstein cattle: anatomical, histological, and genetic studies
Authors: Gehrke Marek , Blaszak Beata , Stachowiak Monika , Szczerbal Izabela , Stefańska Barbara , Jaśkowski Jędrzej M. , Nowak Włodzimierz , Świtoński Marek
Published: September 2019

Introduction

A comprehensive description is presented of four novel cases ofamorphus globosus (ag) foetuses originating from multiple pregnancies of Polish Holstein cows.

Material and Methods

Four amorphic foetuses were delivered by three cows. Tissue samples were collected during autopsy, embedded in paraffin, sectioned, and stained with haematoxylin and eosin. Genomic DNA was isolated from tissue samples of abnormal foetuses and from blood leukocytes of their healthy siblings. PCR reactions were used to reveal the presence of Y-linked genes (SRY and AMELY) and an X-linked gene (AMELX).

Results

All foetuses were classified to the groupholoacardius amorphous (anideus). Molecular analysis clearly showed that at 17 microsatellite loci, the studied amorphous foetuses had identical genotypes to the viable co-twins.

Conclusion

Foetuses had monozygotic origin. Histological analysis showed a low level of development of tissues of meso- and ectodermal origin, as well as features of degrading patterns.
How Robot/human Orchestration Can Help in an HR Department: A Case Study From a Pilot Implementation
Authors: Šimek Dalibor , Šperka Roman
Published: September 2019

Background and Purpose: Motivation of this research is to explore the current trend in automating the business processes through software robots (Robotic Process Automation – RPA) and its managing within enterprise environment where most of the processes are executed by human workforce. As the RPA technology expands the demand for its coordinating grows as well. The possible solution to this challenge is shown in case study research in form of implementing orchestration platform to a concrete business process of onboarding in HR department of a multinational company. The aim of this paper is to explore the phases and activities of the pilot project implementation of Robotic Service Orchestration (RSO) in combination with RPA technology and to assess the potential benefits.

Design/Methodology/Approach: Case study research approach was selected to explore the research phenomena, which is the implementation of RSO platform in combination with RPA technology and assessing incoming benefits. The case is formed with 2 companies – (1) multinational company with ongoing effort of automating onboarding process, (2) technology and consulting company delivering the automation solution. Data were collected through semi-structured interviews with respondents from two involved companies and by analysing internal documents.

Results: The analysis of case provided in this paper revealed some key insights: (1) strategical position of RSO and tactical position of RPA towards the existing legacy systems, (2) need for increased focus on initial process modelling phase, (3) Application Programming Interface (API) integration is more viable solution for RPA, (4) the biggest benefit of RPA - its agility, (5) future potential of the RSO replacing the BPMS.

Conclusions: First of all, there is a need of higher number of software robots adopted in a company before orchestration could pay off. On the other side, current Business Process Management Systems (BPMS) solutions don’t offer functionalities for managing human and software robots workforce altogether. RPA is expected to expand and without proper orchestration the effectivity will not grow constantly.
Experimental and statistical analysis of blast-induced ground vibrations (BIGV) prediction in Senegal’s quarry
Authors: Kadiri Imad , Tahir Younès , Iken Omar , Fertahi Saïf ed-Dîn , Agounoun Rachid
Published: September 2019

Extractive industries often use explosives to destroy rocks, and productivity requirements tend to increase the charges of the explosives. The blasts induce vibrations, which result in a potential damage of the surrounding structures. Therefore, the prediction of vibrations should be described with accuracy, in order to ensure the safety of engineered structures. However, the prediction of vibrations’ levels remain a complicated issue, because it involves numerous parameters correlated to the quarry site.

In this paper, statistical analysis based on the peak particle velocity (PPV) and the attenuation law has been carried out to assess the safety charges (Q) for different distances (R) between the blast and the considered structure to secure. Moreover, the experimental investigations were conducted on the quarry site of “Sococim”, which is located on the south coast of Senegal. To ensure the safety of the “Conveyor belt” and “Panel 1 (Upper exploitation level)” sites, the PPV should be less than 10 mm/s. In fact, the attenuation model has been used to assess the safe charge weights of the explosive (Q) to be used at the “Conveyor belt” site and at the “Panel 1 (Upper exploitation level)” site. Therefore, the safe charge weights per delay (Q) were respectively 116 kg and 13.75 kg.
Use of 99mTc-MIBI spect in estimating the efficiency pre-operative treatment of the larynx and laryngopharynx cancer
Authors: Medvedeva A. A. , Chernov V. I. , Zeltchan R. V. , Sinilkin I. G. , Bragina O. D. , Choynzonov E. L. , Chizhevskaya S. Yu. , Belevich Yu. V. , Gol’dberg V. E.
Published: September 2019

Purpose of the study. To study the possibilities of 99mTc-MIBI single photon emission computed tomography (SPECT) at the monitoring of the preoperative treatment of patients with laryngeal and hypopharyngeal cancer. 

Materials and methods. The study included 28 pa tients with cancer of the larynx or laryngopharynx T2–3N0–2M0. 99mTc-MIBI SPECT was performed for all patients before and after preoperative treatment, semi-quantitative indices were calculated, according to SPECT 

Results. A statistically significant difference was observed in the retention index in patients with complete regression and stabilization. A lower retention index is observed in patients who had a clinically pronounced effect from preoperative treatment. The rate of radiotracer washout from the tumor was faster in patients with no effect of preoperative therapy. The level of radiopharmaceuticals uptake in the tumor tissue after preoperative treatment was significantly lower in the group of patients without progression than in the group of patients with progression of the disease. In addition, the accumulation of the radioindicator after preoperative chemotherapy increased in the group of patients with progression, and decreased in the group without progression.

Conclusion. The 99mTc-MIBI SPECT for tumor monitoring during treatment can be used. Semi-quantitative indices can be used as predictive criteria of results of preoperative treatment, as well as prognostic criteria for monitoring of such patients.
Perforation of the jejunum diverticulum: the role of CT examination
Authors: Platitsyn I. V. , Kondratyev A. V. , Panin A. V. , Shubarkina E. M. , Maslov A. L.
Published: September 2019

Uncomplicated diverticula of the small intestine are asymptomatic, extremely rare in everyday practice and, most often, are detected already with the development of complications such as perforation and abscess formation. Diagnosis of complicated diverticula of the small intestine is difficult due to many other, more common causes of acute abdomen, insufficient use of the capabilities of the methods of radiation diagnosis, the lack of application and correct interpretation of the results of instrumental and special research methods. The article presents a clinical case of perforation of the jejunum diverticulum. The results of effective MDCT diagnosis and successful surgical intervention are presented: laparoscopic resection of the jejunum with the formation of the primary hardware intracorporeal enteroentero-anastomosis side by side.
Cultural adaptation and validation of the Geriatric Oral Health Assessment Index - GOHAI - Colombian version.
Authors: Gutiérrez Quiceno Bruno , Calzada Gutiérrez María Teresa , Fandiño Losada Andrés
Published: September 2019

Objective: This study aims to carry out the cultural adaptation and the validation of the GOHAI scale for the Colombian population.
Methods: Translation process, cultural adaptation, and content and face validity were carried out with a sample of 63 participants as a pretest. The validation counted with a sample of 7,200 subjects, divided into two groups: a work sample (WS) with 3,628 subjects and a confirmatory sample (CS) with 3,572 subjects. Construct, criterion validity and internal consistency were performed for both samples. Test-retest reliability was assessed with a sub-sample of 75 participants
Results: The GOHAI showed an appropriate face and content validity, the pre-test revealed an understandable questionnaire, the scale showed a unidimensional factorial structure and a Cronbach’s Alpha of 0.8. Convergent validity with a self-perception on general health scale pointed to a significant correlation (p= 0.0001), while discriminant validity showed significant differences regarding groups according to age group, skin color, educational level, socio-economic level, healthcare affiliation and self-perception about need of dental prostheses. Gender groups did not show significant differences among groups within either sample. The CS showed similar results, differences existed among factorial structures of 2 and 3 factors, and for discriminant validity, the CS showed statistically significant differences for the Area variable not in the WS. Kendall’s test-retest analysis’s correlation is 0.85 (p= 0.0000).
Conclusion: The GOHAI scale is valid and reliable enough to be used as a measure of OralHealth-Related Quality of Life in the Colombian elderly population, also could be applied for other Latin-American populations.
Religiosity and self-rated health among older adults in Colombia
Authors: Reyes Ortiz Carlos , Payan Villamizar Claudia , Altamar Geraldine , Gómez Fernando , Koenig Harold
Published: September 2019

Objective: To identify the relationship between religiosity and self-rated health among older adults in Colombia.
Methods: Data are drawn from the SABE (Salud, Bienestar y Envejecimiento) Colombia Study, a cross-sectional survey conducted in 2015 involving 18,871 community-dwelling adults aged 60 years and older living in urban and rural areas of Colombia. Religiosity was assessed by self-rated religiosity (how religious are you: not at all, somewhat or very). Self-rated health during previous 30 days was assessed as very good, good, fair, poor or very poor, analyzed as an ordinal variable(1-5) using weighted logistic regression, adjusting for confounders.
Results: Those who were more religious were older, female, had lower socioeconomic status, and were more likely to be married. Multivariate analyses demonstrated that older adults who were more religious had better self-rated health (OR 0.92 95% CI 0.860.99, p= 0.038); however, there was a significant interaction effect between gender and religiosity on self-rated health (p= 0.002), such that the relationship between religiosity and health was stronger in men (OR 0.86, 95% CI: 0.79-0.94, p= 0.001) but not significant in women.
Conclusion: Older adults in Colombia who consider themselves more religious, especially men, are less likely to perceive their physical health as poor compared to those who are less religious.
Research: a priority for the decade of healthy aging
Authors: Vega García Enrique
Published: September 2019

It is a great opportunity to be part of the publication of this special issue dedicated to agingand health; I thank the editors for this opportunity. The relevance of this publication is notaccidental, population aging is undoubtedly one of the most formidable challenges that publichealth must face in this century. It is a global challenge, but for the Americas, and especially forLatin America and the Caribbean, it is already an inescapable one.The last decade has been important for public health and aging in the Americas. With pride,we can affirm that in these ten years, no Region has advanced as much as ours. In 2009, theMinisters of Health of the Americas were pioneers in approving an action plan on Agingand Health, the first in the world; in addition, the Americas was the first, and so far the onlyregion in the world, to approve a protection mechanism for the rights of the elderly, the Inter-American Convention on the Rights of Older Persons, in 2015.
THE INFLUENCE OF BUILDING ENVELOPES TOWARDS INDOOR CLASSROOM TEMPERATURE (Case: BINUS Alam Sutera Campus)
Authors: Dewanto Rivanus
Published: September 2019

ABSTRACTThe building façade of BINUS Alam Sutera campus is designed with wall variations of building envelope both in terms of material use and of openings volume. These conditions encourage the researcher to observe how much the indoor temperature difference in the classroom is correlated to the wall completion of the building envelope. The method used was by measuring indoor and outdoor temperatures at the same time periods (morning, midday, and afternoon) from the classrooms in different floors. The result of the study reveals that indoor temperature increases relatively towards the sun orientation of north-northeast and of west-southwest. The building envelope with precast concrete and window-wall affects indoor temperature relatively higher in the morning and lower in the afternoon. Whereas the building envelope with precast concrete of dead-glass variation affects indoor temperature relatively lower in the morning yet higher in the afternoon.Keywords: Building envelopes, indoor temperature, classrooms
THE ENFORCEMENT OF GOMPONG IN THE QANUN OF ACEH AND ITS RELATIVE POSITION IN THE INDONESIAN CONSTITUTION
Authors: Iskandar Mizaj
Published: September 2019

This paper aims to learn how the Qanun of Aceh, particularly Qanun No. 4 on Mukim and Qanun No. 5 on Gampong Government enforce Gampong as a government body. It further compares the hierarchical relationship between the qanun and the higher regulations in Indonesia such as Village Government Act No. 32 of 2004, Privileges of Aceh Act No. 44 of 1999, Special Autonomy No. 18 of 2001 and Aceh Government Act No. 11 of 2006. The study found that the Qanun integrates Acehnese identity coupled with the Islamic values into the Gampong institution. The Qanun on Gampong Government, in fact, does not negate any higher regulations in the Indonesian constitution. The principle of decentralization implemented post-Orde Baru requires a massive change in the government system in Indonesia from the centralized system of local state government, to local self-government and finally the decentralized system of the local community. The Qanun on Gampong government is in line with the local community spirit due to greater public participation channeled through Reusam Gampong. Reusam Gampong is the public aspiration, and its application shall not conflict with the higher regulation. In its cultural manifest, Resuam Gampong is an instrument that promotes the marriage between culture and religion into a single government body.
HOW DEMOCRACY IS ELECTION? REASSESSING ARTICLE 18 (4) OF THE 1945 CONSTITUTION AND ITS IMPLICATION TO THE REGIONAL HEAD ELECTION IN INDONESIA
Authors: Ulum Muhammad Bahrul
Published: September 2019

This paper aims to reassess the term “elected democratically” in Article 18 (4) of Indonesia’s revised 1945 Constitution which resulted in the competing interpretation over the appropriate method for selecting heads of regional governments in Indonesia. In fact, the flexibility of such a term was challenged and negotiated to formulate an appropriate mechanism to select heads of regional governments. In 2004, the Constitutional Court concluded that the legislative body was the ultimate institution to interpret “elected democratically” so that this institution can opt whether a regional head election or an indirect election to define such a term. While the regional head election was applied, including its dispute settlements over electoral results to the Constitutional Court, this Court considered a different argument. In 2013, the Constitutional Court reinterpreted such an article by highlighting that the regional head election should be exempted from the general election subjected to Article 22E (2) of 1945 Constitution. In 2014, President Yudhoyono’s rejection from his agreement after the enactment of the Selection of Heads of Regional Governments Bill put further juridical contentions in which the President finally revoked the adoption of the regional head voting by the Regional People’s Representative Council or Dewan Perwakilan Rakyat Daerah (DPRD). As a consequence, the regional head election has been re-adopted and this regional election has remained to be expected to improve the performance of local democracy. The introduction of this direct election model at the regional level, however, questions the important role of political parties because the adoption of this election was substantially to answer public distrust against them. In particular, the debate whether political parties work becomes intense after non-party candidates are allowed to contest to this election.
Coaction of Electrostatic and Hydrophobic Interactions: Dynamic Structural Constraints on Disordered TrkA Juxtamembrane Domain
Authors: Wang Zichen , Fan Huaxun , Hu Xiao , Khamo John , Diao Jiajie , Zhang Kai , Pogorelov Taras
Published: September 2019

Effective transmembrane signaling is vital to the life of the cell. However, plasma membrane dynamics pose numerous challenges for signaling proteins and attempts to study them. The receptor tyrosine kinase family transmits signals via a single transmembrane helix and a flexible juxtamembrane domain (JMD). Detailed

studies of JMD-membrane interactions are challenging due to naturally slow lipid diffusion. We employ a combination of all-atom molecular dynamics of highly mobile membrane mimetics with in vitro and in cell experiments to capture critical roles of electrostatic and hydrophobic membrane-JMD interactions of

tropomyosin receptor kinase A (TrkA). We show that a conserved three-residue hydrophobic patch enables JMD anchoring in the membrane, a single residue deletion can dramatically reverse it, and a single charged to hydrophobic residue mutation can enhance binding affinity. The highly charged anionic lipids are effective

at promoting binding and restraining JMD flexibility. Our work highlights versatility of molecular controls of these interactions.
High-Entropy Alloys as Catalysts for the CO2 and CO Reduction Reactions
Authors: Pedersen Jack , Batchelor Thomas , Bagger Alexander , Rossmeisl Jan
Published: September 2019

Using the high-entropy alloys (HEAs) CoCuGaNiZn and AgAuCuPdPt as starting points we provide a framework for tuning the composition of disordered multi-metallic alloys to control the selectivity and activity of the reduction of carbon dioxide (CO2) to highly reduced compounds. By combining density functional theory (DFT) with supervised machine learning we predicted the CO and hydrogen (H) adsorption energies of all surface sites on the (111) surface of the two HEAs. This allowed an optimization for the HEA compositions with increased likelihood for sites with weak hydrogen adsorption{to suppress the formation of molecular hydrogen (H2) and with strong CO adsorption to favor the reduction of CO. This led to the discovery of several disordered alloy catalyst candidates for which selectivity towards highly reduced carbon compounds is expected, as well as insights into the rational design of disordered alloy catalysts for the CO2 and CO reduction reaction.
Water Structure on Mica Surfaces: Investigating the Effect of Cations
Authors: Zhou Jiarun , Lata Nurun Nahar , Sarupria Sapna , cantrell will
Published: September 2019

We studied thin films of water at the mica-air interface using infrared spectroscopy and molecular dynamics simulations. We investigate the influence of ions on interfacial water by exchanging the naturally occurring K+ ion with H+/Na+, Ca2+, and Mg2+. The experiments do not show a difference in the bulk structure (i. e. in the infrared spectra), but indicate that water is more strongly attracted to the Mg2+ mica. The simulations reveal that the cation-water interactions significantly influence the microscopic arrangement of water on mica. Our results indicate that the divalent cations result in strong water-mica interactions, which leads to longer hydrogen bond lifetimes and larger hydrogen bonded clusters of interfacial water molecules. These results have implications for surface-mediated processes such as heterogeneous ice nucleation, protein assembly and catalysis.
Multimodal Fusion of Lipid MALDI IMS with a Transgenic Fluorophore
Authors: Jones Marissa A. , Cho Sung Hoon , Patterson Nathan Heath , Van de Plas Raf , Spraggins Jeffrey , Boothby Mark R. , Caprioli Richard M.
Published: September 2019

Matrix-Assisted Laser Desorption/Ionization (MALDI) Imaging Mass Spectrometry (IMS) allows simultaneous mapping of thousands of molecules distributed in tissues. However, unambiguous identification of specific types or functional states of cells and correlation of such features to molecular localization are key challenges in the field. We report here the development of advances based on identity marking using a genetically encoded fluorophore. The fluorescence emission (Fem) data were integrated with IMS outputs through multimodal image processing with advanced registration techniques and data-driven image fusion. In an unbiased analysis of spleens, this approach enabled identification of new lipid species previously not identified in germinal centers (GC), such as the enrichment of ether lipids. We propose that this use of genetic marking of microanatomical regions of interest can be paired with molecular information from IMS for any tissue, cell type, or activity state for which fluorescence is driven by a gene-tracking allele.
Exploiting In-Situ NMR to Monitor the Formation of a Metal-Organic Framework
Authors: Jones Corey , Hughes Colan , Yeung Hamish , Paul Alison , Harris Kenneth D. M. , Easun Timothy
Published: September 2019

The formation processes of metal-organic frameworks are increasingly widely researched using in-situ techniques, although there remains a scarcity of NMR studies in the field. In this work, the synthesis of MFM-500(Ni) has been investigated using the Combined Liquid- And Solid-State In‑situ Crystallization NMR strategy, which provides information on the time-evolution of both solid and liquid phases during crystallization. In our NMR study, the liquid-phase NMR data recorded as a function of time at five fixed temperatures afford qualitative information on the solution-phase processes and quantitative information on the kinetic parameters of crystallization, allowing the activation energies for nucleation and growth to be determined. Ex-situ SAXS studies provide complementary nanoscale information on the rapid self-assembly prior to crystallisation, and in-situ PXRD confirms that the only crystalline phase present during the reaction is phase-pure MFM-500(Ni).
External cueing on gait parameters in Parkinson’s Disease
Authors: Deepa S  , Ramana K
Published: September 2019

Parkinson’s disease which is characterized by paucity of movement, leading to the abnormal gait parameters. The gait pattern is characterized by shuffling as festinant gait. Freezing is an incapacitating motor symptom is also one of the leading causes of gait abnormality leading to falls. Cueing strategy evokes a more goal-directed type of motor control results in improved gait parameters. Aims and Objectives:-The purpose of this study to find the effectiveness of external cueing on the gait parameters as cadence, step length and stride length. Materials and Methodology: - 30 subjects diagnosed as Parkinson’s disease were randomly assigned to three groups, the walking ability was assessed using a 10 meter walk test, and pre test score was recorded. The external cueing technique was applied for a session of 4 days per week for 4 weeks; each session lasted for about 30 minutes, at the end for 4 weeks the post test scores were recorded. Results: - External cueing with a combination of audio- visual showed significant improvement in the gait parameters. Conclusion: - The improvement showed in the pre test to post test reflected the need for introducing the external cueing in improving gait and attention during a motor task.
A Ópera está morta! Viva a Ópera! A Revitalização da Ópera no Distrito Federal
Authors: Dornellas Janette
Published: September 2019

Esse artigo apresenta um breve histórico da história da ópera no Distrito Federal, mencionando pessoas e eventos que foram significativos nesse processo. Para um melhor entendimento do texto, no tópico 2 discorreremos sobre demandas cênicas e vocais da arte operística. Nos tópicos 3 e 4 falaremos sobre a importância da subvenção pública para a ópera em todo o mundo e os desafios de se produzir óperas de qualidade com pouca verba. Na Conclusão, abordamos um pouco da história do apoio do FAC (Fundo de Apoio à Cultura) e como os editais vem mudando e se adequando cada vez mais a realidade. Também fizemos um levantamento das óperas produzidas entre os anos de 2011 a 2016 com o apoio do FAC – Fundo de Apoio à Cultura do DF, com um quantitativo de óperas realizadas e valores disponibilizados.
Entre ensaios e transformações no processo criativo do espetáculo Rei David (2012) com Hugo Rodas
Authors: Silva Angélica Beatriz Souza e
Published: September 2019

Este artigo apresenta algumas discussões sobre o processo criativo de Hugo Rodas na montagem do espetáculo Rei David, com roteiro e músicas de Marcus Mota, apre- sentado em 2012 em Brasília. O foco consiste em analisar a condução dos ensaios, a relação de direção de Rodas com o elenco e as transformações que se sucederam construção do espetáculo.
Gambaran Pelaksanaan Program Adiwiyata di SD Pertiwi Kota Makassar
Authors: Jusman Jusman , Ardi Muhammad , Rauf Bakhrani
Published: September 2019

Pelestarian lingkungan hidup merupakan kebutuhan yang tidak dapat ditunda lagi dan bukan hanya tanggung jawab negara saja, melainkan tanggung jawab setiap insan di bumi. Upaya pemerintah untuk mewujudkan kehidupan adil dan makmur bagi rakyatnya, harus disertai dengan tindakan pencegahan kerusakan lingkungan. Berbagai program pembangunan berkelanjutan dilakukan sebagai bagian perlindungan kualitas lingkungan. Salah satu program pembangunan berkelanjutan di bidang lingkungan, adalah pendidikan lingkungan hidup yang dimulai pada tingkat SD, SMP, SMA/SMK. Artikel ini membahas gambaran pelaksanaan program Adiwiyata. Program adiwiyata yaitu sekolah yang peduli terhadap lingkungan sekitarnya, yang meliputi sekolah bersih, sehat, indah serta lingkungan berwawasan global yang mengharapkan semua orang ataupun warga sekolah dapat sadar akan betapa pentingnya lingkungan sekitar. Maka dari itu sekolah yang menjalankan program adiwiyata memiliki kebijakan pengintegrasi pendidikan lingkungan hidup, seperti pada sekolah dasar pertiwi di kota makassar yang menjadi penelitian ini.
Frequency of Smart Phone Usage in Medical Students and its Association with Academic Performance
Authors: Ali Hatim Haider , Muhammad Imran  , Noori Yahya
Published: September 2019

Background: Smart phone use is becoming a severe mental health problem as it is becoming dominant with the passage of time leading to dependency and diverting individual’s concentration. The addiction is not only confined to youth, it can be observed among individual of all ages. Through this study our aim was to observe the smart phone usage frequency and its association with academic performance among university students.
Methodology: A cross sectional study was conducted on a total of 400 students of Dow university of health sciences between January 2016 – January 2017. The problematic mobile phone usage scale (PUMP) was used to evaluate the smart phone addiction level and grade point average (GPA) of previously attended semester was analyzed to evaluate its association with academic performance.
Results: It was observed that 134 out of 400 participants were spending 1-2 hrs. daily on mobile phone usage. A strong association was observed between frequency of smart phone usage and academic performance. Moreover, control loss and dependence were also affecting the academics among the study participants. In this study we observed that female students with frequent smart phone use had greater chances of having poor academic performance as compared to males.
Conclusion: It can be concluded form the study results that excessive smart phone usage affects academic performance and hence results in increased dependence leading to lack of concentration, decreased confidence, reduced public dealings and face-to-face interactions. Furthermore, the use must be restricted as in long term it is leading to several health issues especially among youth.
An Analysis of 2nd Graders’ Problem Solving Strategies on Early Algebra
Authors:   The Korea Society Of Educational Studies In Mathematics, Lim Miin , Chang Hyewon
Published: September 2019

The purpose of this study was to investigate the preparation for learning algebra of 2nd graders and to derive some didactic implications of transition from arithmetical thinking to algebraic thinking. 100 2nd graders in elementary school were selected as subjects of this study from H, J, K, W elementary schools in Seoul, and B elementary school in Gyeonggi-do. These students were found to be less than 1st level of arithmetical thinking as a result of the preliminary test according to the arithmetical thinking level test developed by Lim & Chang(2017). Questionnaires were prepared by adapting and reconstructing four word-problems for preparing algebraic learning which are proposed to be available to 1st and 2nd graders in elementary school by Caldwell et al.(2011), and Caldwell et al.(2014). Using the questionnaires, the students’ problem solving strategies were analyzed. From the results of the analysis, some meaningful implications for helping early algebraic learning and the elementary students’ transition from arithmetical thinking to algebraic thinking were found.
MEMAHAMI MANUSIA MELALUI DIMENSI FILSAFAT (Upaya Memahami Eksistensi Manusia)
Authors: Aryati Azizah
Published: September 2019

Filsafat manusia atau antropologi filsafat merupakan bagian integral dari sistem Filsafat yang secara spesifik menyoroti hakikat atau esensi manusia. Sebagai bagian dari sistem filsafat, secara metodis ia memiliki kedudukan yang kurang lebih setara dengan cabang-cabang filsafat lainnya seperti; etika, kosmologi, epistemologi, filsafat sosial dan estetika. Semua cabang filsafat tersebut pada prinsipnya bermuara pada esensi manusia dengan menyoroti gejala dan kejadian manusia secara sintesis dan reflektif, serta memiliki ciri-ciri ekstensif, intensif dan kritis. Kalau demikian, maka dengan mempelajari filsafat manusia bererti kita dibawa ke dalam panorama pengetahuan yang sangat luas, dalam dan kritis, yang menggambarkan esensi manusia. Panorama pengetahuan seperti itu, paling tidak memiliki manfaat ganda yakni manfaat praktis dan teoritis.
Resilience on Human Trafficking Victims in West Java
Authors: Borualogo Ihsana Sabriani
Published: September 2019

There are cities/districts in West Java which have high number of human trafficking cases. Human trafficking victims experienced psychological distress due to violence they have experienced. The aim of this research is to describe resilience on human trafficking by using theory from Michael Ungar. This research used descriptive method with purposive sampling technique. Samples taken are 33 women, age 15-23 years old, mostly graduated from junior high school (16 persons = 49%). Data was collected using resilience questionnaire CYRM-28 which created by Michael Ungar. Research findings showed 69.7% of victims have high resilience. In socio-ecological dimension, which is relationship with caregiver (mean = 3.96) and context/sense of belonging (mean = 3.96) have higher mean compare to individual dimension (mean = 3.79). In socio-ecological dimension, psychological caregiving (mean = 4.15) and spiritual (mean = 4.10) are two important indicators which help individuals to become resilient. In individual dimension, personal skill (mean = 3.85) is the important indicator which must be owned by individuals to become resilient.
Determinants of Social Poverty in Mountainous Areas of Talegong, Garut Regency
Authors: Aspiranti Tasya , Amaliah Ima
Published: September 2019

Poverty is a multidimensional problem since it is not only an economic problem but also a social, political and even cultural problem. The purpose of this research is to identify the determinant factor of social poverty in the mountain region of Talegong Subdistrict. The research type is quantitative descriptive with field survey method. The analysis technique using descriptive statistics and the sample is determined by purposive random sampling. The concept of social poverty uses BPS and Chambers indicators. Respondents interviewed were village heads, LPMDes, community leaders and communities in seven villages in Talegong sub-district. Based on the results of observations and interviews with respondents, there are four determinants of social poverty in Talegong sub-district: the factor of poverty itself, abandonment, alienation & remoteness and vulnerable to natural disasters. While three other factors such as physical, mental and social neglect factors; social impairment factor  and behavioral deviation from religious and community norms, and factors of victims and physical, mental and social violence were not found in Talegong sub-district.
Problem of Public Accountability in Village Governance in Rural Enrekang, Indonesia
Authors: Nurlinah Nurlinah , Haryanto Haryanto , Musdah Erwin
Published: September 2019

This article examines a range of issues in the implementation of village governance to enhance public accountability. Subsequent to  village law, a village now has to deal with how to manage government finances by promoting public accountability knowing that public accountability is the spirit of reviving democracy in village government. This study investigates the practice of village fund governance by collecting qualitative data from 9 villages in Enrekang Regency, South Sulawesi. The villages were randomly selected, one village in 9 sub-districts of 12 sub-districts in Enrekang. There were three primary causes of the lack of public accountability, namely: institutional arrangement, social organizations, and local culture. In practice, each cause has a different impact on determining the level of accountability in a village. It implies that the principles of good governance are still not fully embraced by local villagers and village government.