bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Media Pembelajaran Aplikasi Asobiba untuk Meningkatkan Kemampuan Kosakata Bahasa Jepang pada Mahasiswa
Authors: Al Ghiffari Muhammad Ghozy , Al Ghiffari Muhammad Ghozy , Sukmara Rina
Published: January 2025

Penelitian ini bertujuan untuk menguji efektivitas aplikasi smartphone Asobiba dalam meningkatkan kemampuan kosakata bahasa Jepang pada mahasiswa Program Studi Pendidikan Bahasa Jepang semester 3 di salah satu universitas di Jakarta. Penelitian ini merupakan penelitian quasi eksperimen dengan menggunakan pendekatan kuantitatif dengan desain pretest-posttest control group design. Data dikumpulkan melalui tes kosakata bahasa Jepang sebelum dan sesudah intervensi menggunakan aplikasi Asobiba. Analisis data dilakukan dengan menggunakan metode statistik deskriptif dan uji beda rata-rata. Berdasarkan perhitungan uji-t yang telah dilakukan pada kelas eksperimen diperoleh nilai sig. 000 maka jika nilai probabilitas sig (2-tailed) atau (sig ≤0,05) maka Ho diterima. Jadi terdapat efektivitas penggunaan aplikasi Asobiba untuk meningkatkan kosakata bahasa Jepang mahasiswa semester 3 salah satu universitas di Jakarta.
The Noteworthiness of Negotiated Understandings on Japanese Flash Fiction Entitled Two Frogs
Authors: Pasopati Rommel Utungga , Napitupulu Johanes Claudio Perdana , Wulandari Siti , Wijaya Kusuma , Kartiningsih Rindrah
Published: January 2025

This article exposes crucial points of negotiated understandings between two characters in Japanese flash fiction entitled Two Frogs. The story tells about the different dreams between two frogs that have plans to reach their destination to see another town. This folktale wants to tell the readers about the similarities between Kyoto and Osaka. Through qualitative method, this research underlines that, in fact, Kyoto is more traditional than Osaka, but later the characters reach such understandings than flourishing the conflicts. Any difference should be negotiated so that it never comes into bigger conflict. Negotiated understanding then could not be separated from such reciprocal cultural appreciations as well. In conclusion, the description, interpretation, and narration of the story explores indications of moral messages of negotiated understandings. It is simply taken as a token of peace that should always be gained rather than unworthy loss due to upcoming frictions between assumptions and interpretations of the characters.
Inclusive Japanese Language Use In Support Of Gender Equality
Authors: Satriatama Prasetya Eghy
Published: January 2025

Gender-differentiated language use in Japanese stems from traditions and social norms that have developed over time. However, usage  of gender-neutral Japanese is still not very popular in Japan. This article aims to provide an insight into gendered language use, particularly gender-based language use. The method used to write this article is a qualitative approach with an analytical descriptive method. The data is then collected through literature study. Also, the data sources used in this study are books, journals, articles and online news related to the uses of neutral Japanese in Japanese society. In this article, the author analyzes the data obtained from the book "Queer Japanese: Gender and Sexual Identities through Linguistic Practices" by Hideko Abe published in 2010 and “Japanese Language and Gender: An Introduction" by Kadek Eva Krishna Adnyani published in 2019. Based on these two books, it can be concluded that the use of gender-neutral language in Japanese is crucial in creating gender equality and inclusivity for all individuals regardless of their gender. However, language change is not the only solution to creating gender equality. There needs to be a broader effort in changing mindsets and social norms that are not inclusive and respectful of gender diversity.
Animo Anggota POKDARWIS Desa Jehem Pada Pembelajaran Bahasa Jepang Pariwisata
Authors: Pradhana Ngurah Indra
Published: January 2025

One thing that needs to be developed by members of POKDARWIS Jehem Village, Bangli Regency, Bali Province is the ability to serve tourists from Japan. Based on this background, Japanese Tourism language learning was carried out. The activity has been carried out twice, namely on July 26, 2024 and August 13, 2024. The name of the activity is Sakura (One day of gathering together). Each session was attended by around 50 participants. Based on the enthusiasm for the activity, it was grouped quite high. The first evaluation was carried out by means of a test. By giving questions, 93 people were able to correctly answer questions related to greetings and Japanese letters, 75 people were able to write self-introductions in Japanese, the rest still needed improvement in answering. Evaluation of Japanese language training was carried out by distributing questionnaires. The substance of the questions asked included satisfaction after learning Japanese with the results of 2 people saying they were quite satisfied, 77 people saying they were satisfied, and 21 people saying they were very satisfied. Some suggestions were given in the questionnaire, including improving the quality of the videos shown, more in-depth training on pronunciation and memorizing Japanese terms, and further training on the correct use of chopsticks. Practical evaluations include non-test evaluations. Non-test evaluations were conducted on the material on introducing oneself in Japanese and the use of chopsticks by participants. In the practice of introducing oneself, most were able to perform well, but they still seemed embarrassed because they were not yet confident in pronouncing Japanese terms. This was also seen when using chopsticks. Many were still not used to using chopsticks because it was not a habit in everyday life.
Hierarki Kebutuhan Tokoh Handa Seishuu Dalam Live Action Anime “Barakamon”: Psikoanalisis Abraham Maslow
Authors: Falikha Salwa , Oemiati Sri
Published: January 2025

The goal of this study is do describe how Handa Seishuu, the main character, employs hierarchical needs elements. The authors’s research approach is descriptive qualitative. The purpose of this study is to analyze Handa Seishuu's character's hierarchy of wants using Abraham Maslow's psychology theory. This study's data comes in the form of scenes and dialogue lines connected to the research issue. The results showed that Handa Seishuu's character fulfills the stages of hierarchical needs according to Abraham Maslow's theory: 1) psychological needs in the form of food and shelter, 2) Security needs in the form of meeting people who live on Goto Island, 3) The need to be owned and loved in the form of affection from friends, 4) Self-esteem needs in the form of appreciation or praise from others, 5) Self-actualization needs in the form of trying to develop potential.
Efektivitas Media Visual berbasis Teknik Visible Thinking Untuk Meningkatkan Kemampuan Berbicara Dan Kemampuan Menulis Dalam Bahasa Jepang
Authors: Mawitjere Indria
Published: January 2025

This study aims to examine the effectiveness of visual media based on Visible Thinking techniques in improving Japanese speaking and writing skills. Through experiments with third semester students, it was found that the use of visual media combined with Visible Thinking techniques significantly improved their speaking and writing with an average score of 79.58333, while the control class that did not use Visible Thinking-based visual media received an average score of 73.0833. The results showed that the use of visual media based on Visible Thinking technique significantly improved students' speaking and writing skills in Japanese compared to conventional learning methods. Students who used this media showed improvement in the ability to construct more complex sentences, coherence of ideas, and confidence in speaking. The findings indicate that the integration of Visible Thinking technique in Japanese language learning can be an effective strategy to improve students' competence in language skills.
Optimization of irrigation and nitrogen for sustainable rice cultivation: emissions and yield impact
Authors: Ashwini S , Sakthivel N , Pazhanivelan S , Ramah K , Janaki P , Ravichandran V
Published: January 2025

Rice cultivation is integral to global food security and exports but contributes significantly to greenhouse gas emissions, mainly methane (CH?) and nitrous oxide (N?O), exacerbating climate change. This study evaluates the effects of three irrigation practices-conventional flooding (CF), alternate wetting and drying (AWD) and the modified system of rice intensification (MSRI) on CH? and N?O emissions and rice yields over two seasons (Kar 2022 and Samba 2023). A split-plot design with five nitrogen management strategies was employed, with weekly gas sampling and yield measurements at harvest. Among the treatments, the MSRI method, combined with 75% of the recommended nitrogen dose and a 0.4% foliar nano-urea spray (M3S5), recorded the lowest CH? emissions at 50-60 mg CH?/m²/day, compared to 120-130 mg CH?/m²/day under CF. In contrast, N?O emissions under MSRI peaked at 11-13 µg N?O/m²/day, higher than CF (5-7 µg N?O/m²/day). MSRI also achieved the highest rice yields, averaging 6029 kg/ha in Kar 2022 and 6018 kg/ha in Samba 2023, compared to 5500-5700 kg/ha under AWD. These findings highlight the potential of MSRI with optimized nitrogen management as a sustainable alternative, balancing high productivity with reduced CH? emissions and offering a pathway for climate-resilient rice farming.
Diagnosis of hemogobinopathies in the clinical laboratory: an occult Hofu hemoglobin on HPLC
Authors: Urroz Maitane Echeverría , Delgado Ana Isabel López , Conejero Raquel Oliveros , Nistal David Álvarez
Published: January 2025

Objectives

Hemoglobinopathies are disorders affecting the structure, function and/or production of hemoglobin. These conditions are caused by mutations in the genes encoding globin synthesis. The highly variable clinical manifestations of hemoglobin disorders range from asymptomatic forms to severe anemia. Laboratory tests are crucial for diagnosis.

Case presentation

We report the case of a patient who presented with asthenia. Since the patient had a family history of hemoglobonipathies, screening for erythropathies was performed. High-resolution liquid chromatography (HPLC) showed a normal distribution of hemoglobin levels. In contrast, capillary zone electrophoresis at alkaline pH demonstrated an unidentified rapid migration peak. Genetic testing revealed a mutation in the HBB gene causing Hofu hemoglobin disease.

Conclusions

The hemoglobin variant Hofu is slightly unstable. While heterozygous carriers most frequently remain asymptomatic, they may develop anemia in the presence of other concomitant disorders. Distinctively, the retention time of Hb Hofu on HPLC is very close to that of HbA (0) and they often elute together. Therefore, Hb Hofu may remain masked, thereby leading to the misinterpretation of test results.
Carambola fruit fly in Brazil: new host and first record of associated parasitoids
Authors: Costa José Victor Torres Alves , de Sousa Maria do Socorro Miranda , de Souza-Filho Miguel Francisco , Murbach Caio Gianfrancesco , Oliveira Jessica Paula Monteiro , dos Santos Tatiana Pereira , Matos Alain Khristian Borges Teixeira , Edson Nava Dori , Adaime Ricardo
Published: January 2025

Bactrocera carambolae Drew & Hancock (Diptera: Tephritidae), the Carambola fruit fly, is an invasive species in South America. This work aims to confirm the expansion of the host range of B. carambolae and report the occurrence of its parasitism in Brazil. The study was carried out in the Jari Valley region, Pará, Brazil. Two types of sampling of Terminalia catappa L. (Combretaceae) were carried out: one with grouped fruits to verify if they were infested by B. carambolae (Sites A, B, C) and the other with individualized fruits to investigate parasitism (Site C). Morphological analysis was done to confirm parasitism, based mainly on the cephalopharyngeal skeleton embedded in the opercula of the puparia. From the sampling with grouped T. catappa fruit, 2,841 fruit fly puparia were obtained, from which 480 B. carambolae specimens and 1,228 specimens of Anastrepha spp. Schiner (Diptera: Tephritidae) emerged. Site C was the one with the highest fruit fly infestation of T. catappa fruits. We conclude that T. catappa is a moderately good host at Site A and a good host at Sites B and C. From the samplings with individualized fruits of T. catappa, an adjusted parasitism index of 21.2 % was obtained for Anastrepha spp. and 1.8 % for B. carambolae, confirming the presence of the parasitoids Doryctobracon areolatus (Szépligeti), Utetes anastrephae (Viereck) (Hymenoptera: Braconidae), and Aganaspis pelleranoi (Brèthes) (Hymenoptera: Figitidae). The native parasitoids D. areolatus, U. anastrephae, and A. pelleranoi were reported for the first time parasitizing B. carambolae larvae in Brazil.
Tickell’s bat, Hesperoptenus tickelli (Blyth, 1851), in Sri Lanka with new records after 58 years and roosting ecology notes
Authors: Kusuminda Tharaka , Chandrathilake G.G. Thilakawansha , Abegunawardhana Pasindu D. , Abeyrathne Sameera , Senthila Vithanage T. , Amarasinghe Chamara , Mannakkara Amani , Yapa Wipula B.
Published: January 2025

Tickell’s bat (Hesperoptenus tickelli) is a medium-sized bat belonging to the family Vespertilionidae. This species was rarely recorded in recent surveys in its range. Similarly, this species has not been recorded in Sri Lanka since 1963. Further, it is assumed to roost in dense foliage of tall trees. We report three opportunistic records of this species from Sri Lanka after 58 years, along with notes on its roosting ecology. We highlight the importance of comprehensive studies on the life history of this species for better conservation and management.
Mosaic ceramic surface defect detection enhancement algorithm based on guided filter and multi-scale fusion
Authors: Dong Guanping , You Rui , Liu Sai , Wu Nanshou , Kong Xiangyu , Huang Pingnan , Fan Wenting , Wang Zixi
Published: January 2025

This study proposes an enhanced algorithm based on guided filter and multi-scale fusion that detects surface defects of mosaic ceramics, allowing to tackle the small and difficult-to-detect surface reflection problem. This method first combines the gathered multi-angle light source images to obtain the highlight removal image. The guided filter then separates the image into base and detail images. Afterwards, the contrast limited adaptive histogram equalization (CLAHE) algorithm is used to enhance the detailed image. Taplacian contrast weights, saliency weights, and saturation weights are then introduced for the multi-scale fusion of the base and detail images. Finally, defects are extracted by non-linear enhancement, threshold segmentation, morphological processing, and the Canny operator. The proposed algorithm can effectively remove the mosaic ceramic surface highlights, enhance the details of the defect edges, remove the noise interference, improve the overall image quality, and perform rapid detection of defects on the surface of mosaic ceramics. Experiments are then conducted to verify the efficiency of the proposed algorithm. The results show that it has high performance, and it reaches a mosaic ceramic defect detection accuracy of 97.9 % with low leakage and false detection rates of 2.1 % and 1 %.
“Doctor I would like to die. Please help.”
Authors: Muskin Philip R.
Published: January 2025

The request for hastened death by patients with psychiatric disorders poses a professional conundrum for psychiatrists. Issues of transference and countertransference loom large in such situations. Primitive defense mechanisms, particularly projective identification need to be addressed in understanding the request.
Network mechanisms underlying the regional diversity of variance and time scales of the brain’s spontaneous activity fluctuations
Authors: Ponce-Alvarez Adrián
Published: January 2025

The brain’s activity fluctuations have different temporal scales across the brain regions, with associative regions displaying slower timescales than sensory areas. This so-called hierarchy of timescales has been shown to correlate with both structural brain connectivity and intrinsic regional properties. Here, using publicly available human resting-state fMRI and dMRI data it was found that, while more structurally connected brain regions presented activity fluctuations with longer timescales, their activity fluctuations presented lower variance. The opposite relationships between the structural connectivity and the variance and temporal scales of resting-state fluctuations, respectively, were not trivially explained by simple network propagation principles. To understand these structure-function relationships, two commonly used whole-brain models were studied, namely the Hopf and Wilson-Cowan models. These models use the brain’s connectome to coupled local nodes (representing brain regions) displaying noise-driven oscillations. The models show that the variance and temporal scales of activity fluctuations can oppositely relate to connectivity within specific model’s parameter regions, even when all nodes have the same intrinsic dynamics —but also when intrinsic dynamics are constrained by the myelinization-related macroscopic gradient. These results show that, setting aside intrinsic regional differences, connectivity and network state are sufficient to explain the regional differences in fluctuations’ scales. State-dependence supports the vision that structure-function relationships can serve as biomarkers of altered brain states. Finally, the results indicate that the hierarchies of timescales and variances reflect a balance between stability and responsivity, with greater and faster responsiveness at the network periphery, while the network core ensures overall system robustness.

Significance StatementBrain regions exhibit activity fluctuations at different temporal scales, with associative areas displaying slower timescales than sensory areas. This hierarchical organization is shaped by both large-scale connectivity and local properties. The present study demonstrates that the variance of fluctuations is also hierarchically organized but, in contrast to timescales, it decreases as a function of structural connectivity. Whole-brain models show that the hierarchies of timescales and variances jointly emerge within specific parameter regions, indicating a state-dependence that could serve as a biomarker for brain states and disorders. Furthermore, these hierarchies link to the responsivity of different network parts, with greater and faster responsiveness at the network periphery and more stable dynamics at the core, achieving a balance between stability and responsiveness.
An Instant Update on Stem Cell Therapy
Authors: Hoh Yin Kiong
Published: January 2025

Stem cell therapy, a cutting-edge technology, aims to replace damaged cells with healthy ones. Stem cells possess the remarkable ability to multiply and differentiate into various cell types, making them ideal candidates for regenerative medicine. This therapy holds promise for treating a wide range of conditions and injuries. In this review, I will delve into the historical context of stem cell research and therapy, provide updates on clinical trials for different conditions, address the challenges faced in stem cell therapy, and explore strategies to overcome these obstacles. Additionally, I will discuss the ethical and legal implications associated with stem cell therapy. A lesson plan for teaching the challenges and ethical issues of stem cell therapy is found at the end of the review.
The Galician entrepreneurship internationalization matrix: A regulatory framework
Authors: Bouzas Arufe Javier , Portela Maseda Marta
Published: January 2025

This study examines the internationalization strategies of Galician entrepreneurs and SMEs, focusing on early internationalization trends. The main objective is to develop a regulatory framework that enables entrepreneurs and established SMEs to approach foreign markets effectively. From a qualitative approach, the research analyzed data from Galician firms to construct the Galician Entrepreneurship Internationalization (GEI) matrix. Data were collected through surveys and supplemented from the Vigo Free Trade Zone database, covering exporting companies founded between 1999 and 2021. Qualitative analysis and matrix modeling were applied to categorize firms into distinct internationalization stages, considering factors such as market breadth, export intensity, and speed of entry. Four company profiles emerged from the analysis. The findings reveal that newer companies, influenced by technological advances and favorable public policies, tend to internationalize within a year of inception. The GEI Matrix offers valuable insights for public policymakers and business managers aiming to promote early internationalization.
Participación judicial y social de jóvenes en el sistema de responsabilidad penal adolescente colombiano
Authors: Tapias Saldaña Angela Cristina , Latorre-Iglesias Edimer Leonardo
Published: January 2025

Se indagó la forma como los jóvenes sancionados por delitos participan en el proceso judicial, las instituciones y con su comunidad, en razón a que están adscritos a un proceso pedagógico que los prepara para empoderarlos en derechos y ejercer ciudadanía prosocial. Para recabar los datos se aplicó una encuesta a la muestra nacional compuesta por 355 jóvenes. El procesamiento y análisis de la información permiten identificar que los jóvenes no siempre se consideran consultados activamente y que posiblemente exista una generalizada información sobre los procesos, así mismo, el análisis reflexivo caracteriza importantes retos para fortalecer el ejercicio de la participación al interior de las instituciones que conforman el sistema de responsabilidad penal adolescente en Colombia.
Jaunų lietuvių kilmės argentiniečių motyvacija mokytis lietuvių kalbos
Authors: Kalnaitytė Lina , Vilkienė Loreta
Published: January 2025

This paper describes a study that aims to answer the questions: what factors might encourage young Argentinians of Lithuanian origin to learn the Lithuanian language? What are the linguistic attitudes and opinions about Lithuania of young Argentinians of Lithuanian origin? What is their ethnic identity? The research analyzed the responses of 33 Argentinians of Lithuanian origin living in Lithuania and Argentina to a sociolinguistic form, a motivation questionnaire, and 5 semi-structured qualitative interviews with young Argentinians of Lithuanian origin living in Lithuania and Argentina. Descriptive statistics, qualitative analysis, and thematic analysis methods. The results of the data analysis show that the motivation of the research group to learn Lithuanian is quite strong. The research participants are most strongly motivated to learn Lithuanian by their positive attitudes towards the Lithuanian language, Lithuanians, and Lithuania and the weakest by the motivation of the ought-to L2 self. The regression analysis carried out in the study revealed that the motivation of the ought-to L2 self is stronger in the respondents living in Lithuania than in the participants of the research, who are living in Argentina. The older respondents and respondents who have lived in Lithuania for a longer time attitudes towards the Lithuanian language, Lithuanians, and Lithuania are less positive than among the younger respondents and respondents who have lived in Lithuania for a shorter time. Respondents who declared a stronger identity of Lithuanian have a stronger motivation to learn Lithuanian.
Effects of Ionizing Radiation on the Color and Morphology Properties of Leather
Authors: Stanziani Gibba Janete de L. , Oliveira Maria J. A. , Otubo Larissa , Cipriano Joel , Vasquez Pablo A. S.
Published: January 2025

Effective conservation strategies for leather artifacts and art objects are essential for preserving cultural heritage, particularly given the inherent vulnerability of the material to biodegradation, as leather, an organic material, is especially susceptible to this process. Gamma radiation has emerged as a promising method for the disinfestation and disinfection of cultural heritage objects and archival materials. This study aimed to advance the understanding of gamma radiation as a conservation technique for vegetable-tanned snake and chrome-tanned bovine leather, specifically focusing on its effects on chromaticity, surface topology, fiber structure and thermal behavior. Gamma radiation was applied at controlled doses of 1 and 3 kGy, and its impact on the morphology of the leather was assessed using colorimetry within the CIELAB color space and field emission gun scanning electron microscopy (FEGSEM). The findings indicated that gamma radiation at these doses induced minimal alterations in the morphological properties of the leather. The color differences for irradiated and non-irradiated samples were negligible, with total color differences (ΔE) remaining within acceptable limits (ΔE < 3). Moreover, FEGSEM analysis demonstrated that the fiber structure and surface morphology were not significantly compromised by the irradiation process. Thermogravimetric analyses showed similar thermal decomposition between non-irradiated and irradiated samples for both bovine and snake leather, with detailed data analysis indicating thermal stability. The results supported the efficiency of gamma radiation as a conservation technique for both bovine and snake leather artifacts, preserving their aesthetic and structural integrity.
A Comparison of Planned Dose in TBI VMAT Treatment with Dosimetry Using Portal Dosimetry® and IBA MatriXX®
Authors: Sousa Juan , Lima I , Olbi D , Nascimento Lucas , Fidelis Andre , Maciel Maria Luiza , Da Rosa Luiz , Cardoso Simone Coutinho
Published: January 2025

Bone Marrow Transplant (BMT) is an essential therapeutic intervention in the treatment of diseases such as leukemia and lymphoma, where Total Body Irradiation (TBI) plays a crucial role by eradicating residual diseases and inducing immunosuppression, thus facilitating cell transplantation and reducing the risk of graft rejection. Traditionally, TBI has used large radiation fields, which can lead to significant toxicities in organs at risk (OARs) due to challenges in dose optimization. Volumetric Modulated Arc Therapy (VMAT) emerges as a promising technique, offering advantages such as the use of smaller treatment spaces and reduced doses to OARs, which may improve patient quality of life and reduce treatment costs. This study evaluates the effectiveness of VMAT in TBI by comparing the planned dose with the dose measured by quality control systems, such as the MatriXX FFF from IBA and the Portal Dosimetry from the VitalBeam linear accelerator, demonstrating that VMAT is a viable and effective alternative with the potential to optimize therapeutic outcomes in BMT.
Dissolution Enhancement of Ketoconazole by Melt Granulation Co-Processing
Authors:   Laboratory of Pharmacy, Faculty of Chemistry, Autonomous University of Mexico State, Toluca, State of Mexico, Mexico, 50120., Garcia-Radilla Abigail , Ortiz-Reynoso Mariana ,   Laboratory of Pharmacy, Faculty of Chemistry, Autonomous University of Mexico State, Toluca, State of Mexico, Mexico, 50120., Cuevas Gabriel ,   Laboratory of Natural Products Chemistry, Institute of Chemistry, National Autonomous University of Mexico, Mexico City, Mexico, 04510., T. Alcantara-Fierro Edna ,   Laboratory of Pharmacy, Faculty of Chemistry, Autonomous University of Mexico State, Toluca, State of Mexico, Mexico, 50120., G. Santillán Benitez Jonnathan ,   Laboratory of Molecular Biology, Faculty of Chemistry, Autonomous University of Mexico State, Toluca, State of Mexico, Mexico, 50120.
Published: January 2025

Background: Melt granulation (MG) is a simple operation involving a uniform mixture of active ingredients with a melted polymeric carrier. However, this process can also enhance a drug’s biopharmaceutical properties by augmenting its dissolution rate and, thus, its absorption.

Purpose: By applying MG technology, current research focuses on developing co-processed ketoconazole with a higher aqueous dissolution rate than its pure form.

Methods: A measure of how the type and proportion of polymeric carriers affect the crystallinity and dissolution rate of co-processed ketoconazole materials was performed. MG prepared materials in a high-shear mixer using co-povidone (Kollidon®) VA 64, HPMCAS HF as polymeric carriers, PEG 1450 (Kollisolv®) and triethyl citrate as plasticizers.

Results: The co-processed ketoconazole materials exhibited miscibility in the polymeric systems, as indicated by the reduction in the enthalpy of fusion. Drug crystallinity was significantly reduced in the HPMCAS HF polymeric system, confirmed by XRPD and ATR-FTIR studies. The dissolution rate was enhanced by using a higher drug concentration in a co-povidone VA 64 environment; contrarily, for HPMCAS HF, a higher drug dilution was observed to favor the dissolution rate.

Conclusions: MG is a handy, low-cost technology that develops dissolution-enhanced co-processed active pharmaceutical ingredients, spotting specific carrier-drug interactions. MG yields scalable, proven processes, raising interest in its applications in optimizing drug therapeutic efficacy. Ultimately, this technology for dissolution enhancement could bring lower-cost, high-efficiency drugs to improve patients’ quality of life.
Numerical simulation of waste landfill biodegradation: Fitting experimental data
Authors: Buelvas-Hernandez Vladimir , Moreno-Medina Juliana Lucía , Mercado-Montoya Marcela
Published: January 2025

Landfill remains economically viable for the disposal of Municipal Solid Waste (MSW), however, experiences of failure in several Colombian and global locations, lead to soil, water, and air pollution, harming ecosystems, and biodiversity. Numerical models can help improve the design by considering biodegradation, hydraulic, thermal, and mechanical phenomena involved in landfills. This paper presents a simulation of the landfill biodegradation, calibrating parameters to make results match experimental data from previous references. COMSOL Multiphysics was used to implement McDougall's biodegradation model, tracking organic matter transformation into volatile fatty acids (VFA) and methane (CH4) production via acetogenesis. Parameters taken from previous references were recalibrated to fit data from six US landfills. The results for the concentration variation with time for organic matter, VFA and CH4 successfully follows the expected behavior and fits the experimental data. McDougall's 2007 model, successfully implemented in COMSOL, can be calibrated for data from Colombian and global landfills.
Analysis of scientific production on environmental risk assessment in ecosystems with a circular economy
Authors: Sánchez-Suárez Yasniel , Pancorbo-Sandoval José Armando , Leyva-Ricardo Sonia Emilia , Sánchez-Castillo Verenice
Published: January 2025

Ecosystems are currently at risk, and scientific methods have been developed to assess these impacts. In this scenario, the circular economy makes it possible to reuse raw materials and reduce waste. The objective of the research is to analyze the scientific production related to the evaluation of environmental risks in ecosystems with a circular economy approach. Quantitative research was carried out, with a retrospective and descriptive approach, from a bibliometric study in the SCOPUS database in the period 2014 - 2024. The peak of research was 4, where research articles predominated with 7 in 12 areas of knowledge. The most producing country was the United States. The most producing journal was Thunderbird International Business Review with 159. four research lines and their gaps were identified. Environmental risk assessment is much more than a legal requirement; it is an opportunity to demonstrate an organization's commitment to sustainability.
Desarrollo de estrategias de gestión financiera y administrativa para la sostenibilidad empresarial
Authors: Guerrero William Alberto , Camacho-Galindo Stefanny , Guerrero-Martin Laura Estefanía , Arévalo John Carlos , Fernandes Fernando Antônio da Silva , Correa Edinelson Saldanha , Guerrero-Martin Camilo Andrés
Published: January 2025

Este artículo explora cómo las estrategias de gestión financiera y administrativa alineadas con criterios ESG (ambientales, sociales y de gobernanza) fomentan la sostenibilidad empresarial. Utilizando metodología mixta, se combinó revisión de literatura, análisis de datos financieros de empresas colombianas como Grupo Sura, Nutresa y Davivienda, y encuestas aplicadas a 351 líderes empresariales. Los resultados destacan que la integración de prácticas ESG optimiza recursos, reduce costos operativos y mejora la competitividad, evidenciado en un crecimiento del 13,3% en ingresos y un aumento del 26,3% en ganancias operativas. Sin embargo, se identificaron desafíos significativos, como la falta de métricas claras y recursos financieros limitados. Las empresas que adoptan estas estrategias logran fortalecer su resiliencia organizacional, mejorar su desempeño económico y consolidar ventajas competitivas sostenibles. El articulo concluye que la sostenibilidad empresarial no solo es un imperativo ético, sino también una oportunidad para equilibrar el crecimiento económico con la responsabilidad social y ambiental.
First record of Latrodectus hesperus Chamberlin & Ivie, 1935, Western Black Widow (Araneae, Theridiidae), in Slovakia
Authors: Purgat Pavol , Švecová Lucia
Published: January 2025

An alien spider species, Latrodectus hesperus Chamberlin & Ivie, 1935, is reported from Slovakia for the first time. The spider was accidentally transported to northern Slovakia with goods, and it was found in synanthropic habitat. This record confirms the route through which spiders of the genus Latrodectus are imported into Europe. Characteristic features, along with photographs of the habitus and copulatory organs, are presented.
ALÉM DAS FRONTEIRAS
Authors: Adames Bruna , Borges Lucienne Martins
Published: January 2025

A migração, especialmente em contextos involuntários, provoca transformações significativas e pode expor indivíduos a múltiplas formas de violência, resultando em sofrimento psíquico. Este estudo visa identificar e explorar as violências enfrentadas por imigrantes haitianos no Vale do Itajaí-SC. Com uma abordagem qualitativa e exploratória, foram realizadas entrevistas semiestruturadas para a coleta de dados. A análise de conteúdo das narrativas, fundamentada na psicanálise e etnopsiquiatria, revelou que os haitianos sofreram violência racial, xenofobia, violência de gênero, violência conjugal e violência do Estado. Os achados oferecem uma compreensão do impacto da violência na saúde mental desses imigrantes, destacando a urgência de políticas públicas culturalmente sensíveis que enfrentem essas questões.
Differences in Cesarean Delivery Rates for Puerto Rican Mothers in Puerto Rico and in the U.S. Mainland, 2023
Authors: Gregory Elizabeth
Published: January 2025

This report provides health data from the National Center for Health Statistics.
Visuomenės modernizacijos atspindžiai Rusijos imperijos kriminalinėje statistikoje: Kauno, Kazanės ir Odesos apygardų teismų atvejai
Authors: Každanas Robertas
Published: January 2025

Šiame straipsnyje pristatomi Rusijos imperijos visuomenės modernizaciją XIX a. pab. – XX a. pr. reflektuojantys bruožai, atskleisti išnagrinėjus Rusijos imperijos Teisingumo ministerijos parengtų sąvadų medžiagą apie nuteistų asmenų imtį. Pasitelkus istorikų tyrimams naudojamus klasikinius analizės ir sintezės, statistikos bei lyginamąjį metodus, apžvelgiamas ir palyginamas trijuose apygardos teismuose, veikusiuose Rusijos imperijos europinės dalies skirtinguose geografiniuose paribiuose, nuteistųjų vyraujantis socialinis profilis ir jo kismas. Tyrimo metu buvo sudarytos statistines lentelės apie 1884, 1897 ir 1912 metais užfiksuotus nuteistų asmenų socialinius rodiklius.
Sepse precoce em prematuros de Unidades de Terapia Intensiva Neonatal
Authors: Cristina Gomes Lima Raquel , Souto de Medeiros Danielle , Cheles Vieira Verônica , Silvana de Oliveira e Silva Carla
Published: January 2025

Justificativa e Objetivos: apesar dos grandes avanços na assistência neonatal, os óbitos nesse período etário continuam elevados em todo o mundo, destacando-se a prematuridade e a sepse neonatal como as principais causas. Este estudo objetivou avaliar a incidência de sepse neonatal precoce e os fatores de risco materno e neonatal associados de prematuros internados nas Unidades de Terapia Intensiva Neonatais em uma cidade no interior da Bahia. Métodos: estudo de coorte não concorrente, incluindo 268 prematuros internados no dia do nascimento, entre janeiro de 2016 e dezembro de 2017, acompanhados no período neonatal. Foram calculados a incidência de sepse neonatal precoce e seus fatores de risco. Utilizou-se, para análise multivariada, a regressão de Poisson com variância robusta, obtendo-se estimativas do Risco Relativo (RR) e dos respectivos Intervalos de Confiança (IC) de 95%. Considerou-se significância estatística quando valor de p ≤ 0,05. Resultados: incidência da sepse precoce foi 38% (102), sendo que 12,3% (33) tiveram sepse tratada pela clínica e 25,7% (69) apresentaram, também, pelo menos uma alteração laboratorial. O diagnóstico de sepse precoce presumida foi identificado em 63,4% (170); nenhuma sepse foi confirmada com cultura; e a sepse foi afastada em 25,5% (68) dos prematuros. Associaram-se positivamente ao desfecho nascer de parto vaginal (RR: 1,53; IC95%: 1,19-1,97), idade gestacional menor que 32 semanas (RR: 1,86; IC95%: 1,35-2,57), menor que 28 semanas (RR: 2,16; IC95%: 1,59-2,94) e Apgar 5º minuto menor que 7 (RR: 1,45; IC95%:1,14-1,83). Conclusão: houve elevada incidência de sepse precoce, comparada com as pesquisas internacionais e nacionais. Os resultados sugerem necessidade de estratégias para a prevenção da prematuridade e melhoria da assistência durante o parto.
Núcleos Hospitalares de Epidemiologia no Brasil: uma revisão integrativa de literatura
Authors: Faria Dornelas Rodrigo , Lima Sousa Ana Luiza
Published: January 2025

Justificativa e Objetivos: as atividades de vigilância epidemiológica dentro de ambientes hospitalares assumem estruturas e processos de trabalho diversificados segundo as diferentes regiões. Este estudo teve como objetivo mapear os estudos realizados sobre estrutura e/ou processos dos Núcleos Hospitalares de Epidemiologia no Brasil. Método: trata-se de revisão integrativa da literatura realizada nas bases de dados PubMed, Biblioteca Virtual em Saúde (BVS), Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) e Periódicos CAPES, usando descritores pré-definidos. A busca compreendeu o período de 1971 a 2022. A construção deste estudo foi guiada pelos itens de checagem e elaboração do Preferred Reporting Items for Systematic Reviews and Meta-Analysis. O processo de seleção e organização da inclusão e exclusão das publicações foi realizado por meio do aplicativo Rayyan. Resultados: foram identificados 18 estudos, utilizando-se descritores controlados (Epidemiologic Surveillance Services; Hospitals; Health Evaluation) nas bases de dados selecionadas, distribuídos em dez Unidades Federativas. Em relação às buscas por publicações sobre os Núcleos Hospitalares de Epidemiologia, deparamo-nos com estudos sobre outros assuntos que não necessariamente informam sobre o funcionamento ou sistemática de organização. Estes apresentam como objeto, por exemplo, os agravos notificados pelo núcleo. Conclusão: foi identificado que os estudos abordam temas como notificação e investigação de doenças e agravo, e busca ativa. Alguns ainda verticalizam análises sobre integração entre setores dentro do ambiente hospitalar e na rede de assistência externa.  No entanto, são escassos estudos que analisassem a atuação dos núcleos – análise de processos e resultados.
Perfil epidemiológico de pacientes internados por COVID-19 e diagnosticados com pneumonia associada à ventilação mecânica
Authors: Borges Raphaela de Matos , Somensi Rute Merlo , Monteiro Ariane Baptista , Caregnato Rita Catalina Aquino
Published: January 2025

Justificativa e Objetivos: devido às complicações associadas à infecção pela doença do Coronavírus-2019 (COVID-19), houve um aumento de hospitalizações em terapia intensiva e do uso de ventilação mecânica e das infecções relacionadas à assistência à saúde no período pandêmico. Diante disso, objetivou-se conhecer o perfil epidemiológico de pacientes internados por COVID-19 em uma Unidade de Terapia Intensiva (UTI) que desenvolveram pneumonia associada à ventilação mecânica (PAV). Métodos: estudo transversal retrospectivo, com coleta de dados do prontuário eletrônico. Realizado em uma UTI específica para COVID-19, localizada no sul do Brasil, entre julho de 2020 e junho de 2021. Incluíram-se pacientes com COVID-19 que desenvolveram PAV. Excluíram-se aqueles que desenvolveram PAV clínica ou que não apresentavam informações disponíveis para acesso. Resultados: participaram do estudo 54 pacientes, com predominância do sexo masculino (55,6%), faixa etária de 60 anos ou mais (38,9%) e sobrepeso (53,7%). As comorbidades mais prevalentes foram hipertensão arterial sistêmica (63,8%) e diabetes mellitus (20,4%). Identificaram-se somente casos de etiologia bacteriana, com predominância das gram-negativas Acinetobacter baumannii (57,4%),Pseudomonas aeruginosa (24,1%), Klebsiella pneumoniae (20,4%) e de resistência microbiana. O desfecho clínico predominante foi óbito. Conclusão: evidenciou-se um padrão semelhante ao encontrado na literatura relacionado ao perfil de pacientes que internaram em terapia intensiva por COVID-19 e que desenvolveram PAV. Fatores como imunossupressão, idade avançada e doenças crônicas apresentaram predominância nos casos. Condizentemente à literatura, a etiologia bacteriana mostrou-se mais prevalente em PAV, assim como a prevalência de bactérias gram-negativas e com resistência a antimicrobianos.
Perfil clínico, epidemiológico e laboratorial de casos suspeitos de arboviroses durante a emergência do Zika vírus no Brasil
Authors: Francisco Roma José Henrique , Cruz Alves Rachel , Souza Castro Ludiele , Ferreira Márcio José , De Araújo Claudinéia , Moreira Carneiro Bruno , Slhessarenko Renata Dezengrini , Chavez Pavoni Juliana Helena , Ribeiro Resende Mariângela
Published: January 2025

Justificativa e Objetivos: Arboviroses impactam a saúde pública mundialmente, causando graves prejuízos à saúde humana. Os arbovírus causam síndromes febris agudas semelhantes, desafiando o diagnóstico diferencial e a notificação adequada. O objetivo desta pesquisa foi descrever o perfil epidemiológico e laboratorial dos casos suspeitos de arboviroses notificados no sudeste de Mato Grosso (MT) durante a primeira emergência brasileira do Zika vírus. Métodos: as características clínicas e epidemiológicas das arboviroses foram analisadas de forma retrospectiva e descritiva. Amostras de soro foram avaliadas por reação em cadeia da polimerase em tempo real via transcriptase reversa para detecção de Zika, Dengue e Chikungunya, e por imunoensaio para detecção de IgM e IgG contra Zika. Resultados:Dos 197 pacientes, 63% eram do sexo feminino e oito estavam grávidas. A média de idade foi de 32 anos, dos quais 44% tinham 19 e 59 anos; 28% eram brancos; 34% eram alfabetizados; e 58,9% eram residentes urbanos. Cerca de 61% dos casos ocorreram durante os períodos chuvosos, sendo 12,1% em três regiões da área de estudo. Os distúrbios musculoesqueléticos foram as principais queixas (22,8%), seguidos de febre (13,7%), exantema e petéquias (12,6%), cefaleia (11,7%), prurido (10%), manifestações oftalmológicas (6,1%) e manifestações gastrointestinais (5,6%). Por meio de ensaios moleculares, foram detectados 8,9% e 1,7% de Zika e Dengue, respectivamente, nas amostras testadas. Os ensaios sorológicos para Zika mostraram 10,6% de amostras positivas para IgM e 55,8% para IgG. Conclusão: Este estudo fornece o perfil clínico, epidemiológico e laboratorial da emergência do Zika vírus em ambientes de alta endemicidade de dengue. A relevância do estudo é compreender a introdução e ocorrência concomitante de uma nova arbovirose.
Conhecimento e adesão às medidas preventivas da pneumonia associada à ventilação mecânica na pandemia de COVID-19
Authors: Galdino Júnior Hélio , Alves Campos Ana Clara , De Oliveira Montebello Jessica , Oliveira Silva George
Published: January 2025

Justificativa e Objetivos: a COVID-19 aumentou a demanda pela terapia intensiva e intensificou a necessidade de ventilação mecânica e a gravidade da pneumonia associada à ventilação mecânica (PAV). A adoção de medidas preventivas da PAV no contexto da pandemia tem grande impacto para salvar vidas. Assim, objetivou-se avaliar o conhecimento referido sobre o bundle de prevenção da PAV e seus fatores associados e a percepção dos profissionais da equipe multiprofissional sobre a adesão em vigência da pandemia de COVID-19. Métodos: trata-se de estudo transversal, realizado no período de dezembro de 2020 a julho de 2021, com profissionais da Unidade de Terapia Intensiva de hospital universitário. Foram realizadas análises bivariadas e multivariadas para avaliar os fatores associados ao conhecimento dos profissionais. Resultados: dos 61 profissionais entrevistados, 85,25% eram profissionais de enfermagem e 14,75% eram fisioterapeutas. Os fisioterapeutas obtiveram maior porcentagem de acertos em relação aos itens do bundle de prevenção da PAV. Os profissionais de enfermagem possuem pouco conhecimento sobre os elementos que compõem o bundle, remetendo à necessidade de capacitação ao longo de todo o processo de formação e atuação profissional. Falta de treinamento foi a principal dificuldade relatada (14,75%). A idade foi um fator associado ao conhecimento do bundle(p=0,017). Conclusão: há deficiência no conhecimento e na adesão ao bundle de prevenção de PAV entre os profissionais de enfermagem. No entanto, esses profissionais demonstraram disposição em receber capacitação para melhoria das taxas de adesão ao bundle e das boas práticas de prevenção da PAV vigentes.
Titelei/Inhaltsverzeichnis
Authors:   Autor(en)
Published: January 2025

Abstract
Eva Cancik-Kirschbaum: Der Schatten des Turms. Athanasius Kircher inszeniert die globale Katastrophe
Authors: Cancik-Kirschbaum Eva
Published: January 2025

Zu den imaginierten Großkatastrophen der jüngeren Menschheitsgeschichte gehört die Erzählung über den Turm zu Babylon. Der Jesuit und Universalgelehrte Athanasius Kircher hat sich in einem Rekonstruktionsversuch dem Problem eines bis an die Himmel heranreichenden Turmbaus auf ganz eigene Weise angenähert. Das 38. Blatt im ersten Teil seiner Weltgeschichte Turris Babel sive archontologia, veröffentlicht im Jahr 1679, ist eine auf den ersten Blick schlichte, technisch gehaltene Abbildung. Auf den zweiten Blick erschließt sie ein spektakuläres Gedankenexperiment in Sachen Weltenachse.
Eva Cancik-Kirschbaum, Ulrich Nolte, Hermann Parzinger
Authors: Cancik-Kirschbaum Eva , Nolte Ulrich , Parzinger Hermann
Published: January 2025

Eine Achse ist ein stabförmiges Geräteteil zum Tragen oder Aufhängen sich drehender Körper (Grimm’sches Wörterbuch, DWB). Ohne diese bahnbrechende Erfindung, die vor über fünftausend Jahren gemacht wurde, wären Töpferscheiben, Räder, Wagen, Maschinen nicht denkbar. In ihrer komplexen Funktion, etwas sich Bewegendes stabil zu halten, ihm eine Drehung aufzuzwingen, selbst aber in starrer Geradheit in der Mitte zu verharren – als unbewegte Bewegerin –, ist die Achse zu einem machtvollen Bild geworden.