bluuebunny/crossref_metadata_2025 huggingface dataset:
Postoperative features of the macular zone structure after surgical treatment of large full-thickness macular hole using various surgical techniques
Authors:   Research Institute of Eye Diseases, Moscow, Petrachkov D.V. , Alkharki L. ,   Research Institute of Eye Diseases, Moscow, Matyuschenko A.G. ,   Research Institute of Eye Diseases, Moscow, Filippov V.M. ,   Research Institute of Eye Diseases, Moscow, Sidamonidze A.L. ,   Research Institute of Eye Diseases, Moscow
Published: August 2021

Purpose. Comparative assessment of the retinal macular zone structure after surgical treatment of full-thickness macular hole (FTMH) by various methods. Material and methods. Patients with Gass stage III-IV FTMH were divided into 3 groups. Group 1 patients (20 eyes) underwent a standard operation (subtotal vitrectomy (sVE), aspiration convergence of the FTMH edges, gas-air tamponade of the vitreous cavity). Patients in group 2 (20 eyes), after sVE and ILM peeling, autologous conditioned plasma (ACP) were applied to FTMH area followed by air tamponade. Patients of group 3 (20 eyes) after sVE underwent FTMH closure using an inverted ILM flap with the rupture edges approached, followed by air tamponade. Results. The increase in BCVA after 1 month averaged from 0.23±0.1 to 0.41±0.13, (p<0.05) in patients in group 1, in group 2 from 0.15±0, 07 to 0.75±0.09, (p<0.05), in patients in group 3 from 0.14±0.05 to 0.78±0.08, (p<0.05). Anatomical results: in group 1, 17 patients who received standard surgical treatment, a month after surgery, had a satisfactory anatomical result (complete closure of the FTMH with restoration of the correct retinal architectonics in the foveal zone). In 3 patients, additional endovitreal intervention was required with successful FTMH closure. In all patients in group 2, according to OCT data, 5 days after the operation, hyperreflective tissue was detected in the FTMH area ("platelet plug"). When OCT was performed 1 month later, in all cases, the platelet plug resolved, and in all cases, restoration of the foveal profile architectonics was observed. In group 3, the closure of the FTMH on the 5th day of observation was recorded in all patients. When performing OCT after 1 month, complete closure of the neuroepithelium layer was recorded in all cases: in 13 patients - U-shaped closure and in 7 cases – V-shaped. The functional results in both groups were comparable; there was no statistical difference between them. Conclusion: The data obtained demonstrate the morphological features of the retinal foveolar zone postoperative restoration. There was no significant difference in functional results between study groups. Key words: full-thickness macular hole, vitreoretinal surgery, internal limiting membrane, inverted ILM flap, autologous conditioned plasma, optical coherence tomography.
Principles of therapy for subretinal hemorrhage
Authors:   FSBSI ", Petrachkov D.V. ,   Research Institute of Eye Diseases", Korobov E.N. ,   FSBSI "Research Institute of Eye Diseases"
Published: August 2021

Purpose. To study approaches to the treatment of submacular hemorrhage in age-related macular degeneration based on the literature data. Material and methods. The search for publications on the treatment of submacular hemorrhage (SMH) was carried out in the PubMed, SCOPUS, Umedp databases, as well as manually in journals and publications of conference materials until January 2021. Results and discussion. SMH treatment is represented by a variety of methods, from minimally invasive methods, such as intravitreal injection of drugs, gas tamponade and their combinations, to complex surgical approaches with pigment epithelium transplantation. Conclusions. The successful treatment of massive SMH is possible with minimally invasive methods. However, with significant prominating SMH, vitreoretinal surgical interventions are more appropriate. It is advisable to treat SMH as soon as possible from the moment of hemorrhage. Key words: submacular hemorrhage, age-related macular degeneration, pneumodislocation, vitrectomy, anti-VEGF inhibitors, tissue plasminogen activator.
The first experience of using autologous conditioned plasma in the surgery of complete macular ruptures in the Voronezh Regional Clinical Ophthalmological Hospital
Authors:   Voronezh Regional Clinical Ophthalmological Hospital, Roldugin A.A. , Donkareva O.V. ,   Voronezh Regional Clinical Ophthalmological Hospital, Shcherbakov S.Y. ,   Voronezh Regional Clinical Ophthalmological Hospital
Published: August 2021

Purpose. To evaluate the effectiveness of the use of autologous conditioned plasma in the surgical treatment of complete macular ruptures. Material and methods. During 2021, 4 patients with complete macular rupture were operated on at the center of ophthalmic microsurgical high-tech care of the Voronezh Regional Clinical Ophthalmological Hospital using autologous conditioned plasma. The BCVA was 0.01–0.3. The diameter of the macular breaks ranged from 214 to 817 µm. Blood samples were taken from the patients before the operation. Autologous conditioned plasma was prepared by centrifuging the patient's blood in a patented Arthrex ACP (Germany) double-circuit syringe. Surgical treatment was carried out according to the standard technique - microinvasive three-port 25G vitrectomy with removal of the BMR to the extreme periphery and IPM in the central part of the retina. After tamponade of the vitreous cavity with air, autologous conditioned plasma was injected intravitreally into the central and peripheral rupture in several layers until a visual film appeared. The follow-up period for patients after surgical treatment was 2 months. Results. When examining patients after 1 week, the edges of the macular foramen remained closed in all cases. All studied patients noted an improvement in visual functions, the absence of metamorphopsia, a decrease in the dark "spot" in front of the eye, visual acuity ranged from 0.2 to 0.7 (0.5 + 0.2) after surgery for a complete macular rupture, and 0.02 in patients after surgery for recurrent macular rupture. After 1 month, the visual acuity after the full macular rupture was repaired after 1 month was 0.3–0.8 (0.6 ± 0.2), which was significantly higher than the preoperative values, and did not change in the patient with recurrent macular rupture. Two months later - the results of optical coherence tomography and visometry without negative dynamics. Conclusions. The early results of clinical observation confirmed the high efficiency of the use of autologous conditioned plasma in the surgical treatment of complete macular ruptures, which allows to obtain high functional results and anatomical closure of the macular rupture, to increase the efficiency and safety of rehabilitation. Key words: macular rupture, autologous conditioned plasma.
Surgical treatment of extensive submacular hemorrhage in patient with exudative age-related macular degeneration (clinical case)
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation, Rudenko V.A.
Published: August 2021

Purpose. To evaluate the result of surgical treatment of submacular hemorrhage in patient with exudative age-related macular degeneration (AMD) by subretinal injection Gemase® and pneumatic retinopexy of blood clot. Material and methods. The article presents a clinical case of surgical treatment of submacular hemorrhage in patient with exudative AMD. The patient underwent three-port 25G vitrectomy, subretinal injection Gemase® 2000 ME by 38G needle, after which pneumatic retinopexy was performed. Results. Next day after the operation, there was displacement of subretinal blood clot from macula beyond out the lower vascular arcade. When observed after 6 months, the subretinal hemorrhage completely resolved, there was a regression of activity of subretinal neovascular membrane and macular edema, the retina was adherent in all cases. Visual acuity has improved. There was no recurrence of hemorrhage. Conclusion. This method of treatment allows you to increase and maintain the central visual acuity, as well as significantly reduce size of absolute central scotoma. Key words: submacular hemorrhage, recombinant prourokinase, Gemase®, exudative age-related macular degeneration, choroidal neovascularization, subretinal neovascular membrane.
Retinal morphometric parameters of epiretinal membrane in the early period of surgical treatment
Authors:   GAUZ ", Sabirova I.H. ,   RKOB MH RT named by prof. E.V. Adamyuk», Zainutdinova I.I. ,   GAUZ "RKOB MH RT named by prof. E.V. Adamyuk»,   KSMA FGBOU DPO RMANPO, Sabirova L.N. ,   KSMU, Kokoreva E.R. ,   KSMA FGBOU DPO RMANPO
Published: August 2021

The analysis of the morphometric of the retina in patients with epiretinalmembrane was carried out using spectral coherent optical tomography and determination of retinal photosensitivity in the early postoperative period. A decrease in retinal edema was revealed due to a decrease in the thickness of the inner layers of the neuroepithelium in patients with vitreoretinal pathology after surgical treatment. Keywords: epiretinal membrane, morphometric parameters of the retina, vitrectomy, membranopilling.
Retinal detachment in cytomegalovirus uveitis in HIV-infected patients: treatment outcomes
Authors:   Saint-Petersburg Center for Control of AIDS and Infectious Diseases, Sankt-Petersburg, Russian Federation, Sizova T.D. ,   North-Western State Medical University named after I.I. Mechnikov, Sankt-Petersburg, Russian Federation, Khokkanen V.M. ,   North-Western State Medical University named after I.I. Mechnikov, Sankt-Petersburg, Russian Federation, Kasуmov F.O. ,   North-Western State Medical University named after I.I. Mechnikov, Sankt-Petersburg, Russian Federation,   City Multi-field Hospital No. 2, Sankt-Petersburg, Russian Federation, Boiko E.V. ,   North-Western State Medical University named after I.I. Mechnikov, Sankt-Petersburg, Russian Federation,   S. Fyodorov Eye Microsurgery Federal State Institution, Saint-Petersburg Branch, Sankt-Petersburg, Russian Federation
Published: August 2021

Cytomegalovirus (CMV) uveitis in HIV infection is one of the most dangerous secondary diseases of the visual organ, leading to blindness in the absence of treatment. The aim is to characterize the clinical features of the course of retinal detachment in HIV infection. Materials and methods. The study group included 29 patients, 34 eyes (9 men and 20 women). All patients underwent a standard routine ophthalmological examination. To confirm the diagnosis, an ultrasound of the eyeball was performed. Results. Retinal detachment was detected in 29 patients (34 eyes) out of 72 (94 eyes) and was 40.3% (95% CI=29.3-51.79%). According to the mechanism of retinal detachment, the following forms were identified: acute retinal necrosis, regmatogenic and traction detachment. In 50% of cases, the disease occurred as acute retinal necrosis of CMV-etiology. Visual acuity in the group of patients with operated retinal detachment became significantly lower after complex treatment. Conclusions. CMV-uveitis has a chronic sluggish course, despite multicomponent treatment. Retinal detachment is detected in 40% of HIV-infected patients with CMV-uveitis and in half of cases has the character of acute retinal necrosis. Keywords: cytomegalovirus, uveitis, HIV, HIV-infection, AIDS, retinal detachment.
Combined treatment of severe forms of diabetic retinopathy
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Kaluga Branch, Kaluga, Tereshchenko A.V. , Trifanenkova I.G. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Kaluga Branch, Kaluga, Sidorova Y.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Kaluga Branch, Kaluga, Yudina N.N. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Kaluga Branch, Kaluga, Shilov N.M. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Kaluga Branch, Kaluga, Erohina E.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Kaluga Branch, Kaluga, Zhyukova O.M. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Kaluga Branch, Kaluga
Published: August 2021

Purpose. To evaluate the efficacy and safety of combined treatment of proliferative diabetic retinopathy (PDR), including primary vitrectomy and delayed single-stage patterned panretinal retinal laser coagulation (PLC). Material and methods. The study included 28 patients (28 eyes) with newly diagnosed PDD complicated by hemophthalmos and / or local traction retinal detachment with or without 1-2 stage gliosis, against the background of sub- or decompensation of the course of diabetes mellitus (DM). At the initial examination, a standard ophthalmological examination was performed, as well as fundus photography (Visucam 500, Carl Zeiss, Germany), optical coherence tomography (OCT) (STRATUS OCT Carl Zeiss, Germany). The best corrected visual acuity (BCVA) at admission ranged from light projection to 0.4. All patients were undergone combined treatment. Results. 1-1.5 months after pattern PLC, patients showed regression of neovascularization, ischemic zones were completely blocked, in cases of iris neovascularization, its regression was noted. According to OCT data, the height of edema in the macular zone did not increase. In all cases, the removal of silicone oil was completed within 1-2 months. The indices of BCVA increased and varied from 0.1 to 0.7 after the removal of the silicone oil. According to OCT data, 17 patients showed a decrease in the height of retinal edema in the macular zone from 73 to 150 µm. Conclusion. In the postoperative period after vitreoretinated surgery in patients with PDR, one-stage patterned PLC allows to stabilize the course of the disease in a shorter time and shorten the time of silicone tamponade of the vitreous cavity. Key words: proliferative diabetic retinopathy, vitrectomy, silicone tamponade of the vitreous cavity, patterned panretinal laser coagulation of the retina.
Assessment of morphological and functional results of treatment of patients with subfoveal hemorrhage secondary to AMD
Authors:   N.I. Pirogov National Medical Surgical Center, Moscow, Fayzrakhmanov R.R. ,   Institute of Advanced Training of Physicians N.I. Pirogov National Medical Surgical Center, Moscow, Bosov E.D. ,   Institute of Advanced Training of Physicians N.I. Pirogov National Medical Surgical Center, Moscow, Sukhanova A.V. ,   Institute of Advanced Training of Physicians N.I. Pirogov National Medical Surgical Center, Moscow
Published: August 2021

Purpose. The aim of the study was to evaluate the morphological and functional parameters of the retina after subretinal administration of recombinant prourokinase followed by pneumodislocation in comparison with anti-VEGF (Vascular endothelial growth factor) monotherapy in the long term in patients with subfoveal hemorrhage. Material and methods. Depending on the choice of surgical treatment, the patients were divided into two groups: Group 1 – 11 patients (11 eyes) – patients receiving anti-VEGF therapy as the main treatment according to the treat and extend regimen; Group 2 – 9 patients (9 eyes) – patients who underwent translocation of submacular hemorrhage followed by intravitreal administration of anti-VEGF drugs according to the treat and extend regimen. Results. Elimination of the clot to the peripheral regions made it possible to achieve an improvement in the architectonics of the retina in the central zone, in particular, a decrease in the central thickness of the retina in the group with subretinal administration of tissue plasminogen activator by an average of 654.67 µm after 3 months. According to a comparative analysis of morphological parameters at the end of the observation period, in the 2nd group, the decrease in central foveal thickness exceeded the data shown in the 1st group by 16 times. Analysis of the height of choroidal neovascularization showed a depression of the final results 4.34 times relative to the initial values in the combined treatment group. Positive dynamics persisted throughout the entire period of treatment against the background of ongoing anti-vasoproliferative therapy. Conclusion. The technique of subretinal injection of recombinant prourokinase followed by tamponade with an air mixture used in the study demonstrates an increase in visual functions against the background of a favorable anatomical outcome. Key words: submacular hemorrhage, tissue plasminogen activator, pneumodislocation.
Clinical efficacy of subthreshold laser treatment for focal diabetic macular edema using a navigation system (short-term results)
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Volodin P.L. , Ivanova E.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Polyakova E. I. ,   The S. Fyodorov Eye Microsurgery Federal State Institution
Published: August 2021

Purpose. To evaluate the clinical efficacy of subthreshold laser treatment for focal DME with continuous and micropulse mode based on navigated technology. Methods. We observed 17 patients (17 eyes) with DME at the age from 25 to 71 years (on average 44±1.6 years). After the stage of diagnostic search for morphological changes in the retina and preoperative planning all patients underwent navigational laser treatment in and continuous and micropulse mode. The study evaluated the retinal thickness in the foveal avascular zone and outside it, the area of retinal ischemia, microaneurysms and edema zones at the level of the superficial vascular plexus and deep vascular complex. Follow-up periods were 1 and 3 months. Results. One month after laser treatment, all patients had positive dynamics, expressed in a decrease of edema height. BCVA increased on average to 0.8±0.06; mean central retinal sensitivity – up to 24.65±0.47 dB. After 3 months, a further decrease in the height of the edema was observed. BCVA increased on average for the group to 0.85±0.06, mean central retinal sensitivity – 25.5±0.3 dB. Сonclusion. Our preliminary results indicate the effectiveness of navigational subthreshold laser treatment for DME, based on targeted topographically oriented laser exposure according to OCT-angiography. Keywords: diabetic macular edema, navigational laser treatment, subthreshold laser therapy.
Micropulse glaucoma surgery in the combined treatment of neovascular glaucoma
Authors:   S.N. Fedorov NMRC ", Starostina A.V. ,   MNTK ",   Eye microsurgery", Sidorova A.V. ,   S.N. Fedorov NMRC "MNTK "Eye microsurgery", Norman K.S. ,   S.N. Fedorov NMRC "MNTK "Eye microsurgery", Eliseeva M.A. ,   S.N. Fedorov NMRC "MNTK "Eye microsurgery", Khaletskaya A.A. ,   S.N. Fedorov NMRC "MNTK "Eye microsurgery", Smirnova E.A. ,   S.N. Fedorov NMRC "MNTK "Eye microsurgery"
Published: August 2021

Purpose. To evaluate the effectiveness of micropulse laser glaucoma surgery in the combined treatment of patients with secondary neovascular glaucoma. Material and methods. The study included 24 patients (24 eyes) with secondary neovascular glaucoma. All patients underwent micropulse transcleral laser treatment. Results. A week after treatment, the IOP level was 23.1±10.2 mm Hg on the hypotensive drops. A decrease in IOP was achieved by an average of 34% from the preoperative one, and then a gradual decrease in the hypotensive effect was observed with a decrease in IOP by an average of 21-22% from the initial one 1 year after the operation. In 5 cases, in patients with terminal glaucoma, normalization of IOP was not achieved, but in all cases, relief of pain was noted. Conclusion. Micropulse laser glaucoma surgery can be used in the complex treatment of neovascular glaucoma in order to reduce IOP. Key words: secondary neovascular glaucoma, micropulse laser glaucoma surgery, proliferative diabetic retinopathy, CVS thrombosis, anti VEGF.
Retinal macroaneurysm after carotid endarterectomy in patient with chronic ischemic retinopathy associated with hemodynamically significant stenosis of the internal carotid artery (clinical case)
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation, Tuzlaev V.V. , Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Egorov V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Kravchenko I.Z. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation, Smoliakova G.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Yarovaya A.V. ,   Federal Center Cardiovascular Surgery Federal State Budgetary Institution, Khabarovsk, Russian Federation
Published: August 2021

Purpose. To present a clinical case of development of retinal macroaneurysm after carotid endarterectomy (CE) in patient with chronic ischemic retinopathy (CIR) associated with hemodynamically significant stenosis of the internal carotid artery (ICA). Material and methods. Patient R., 74 years old, diagnosed with CIR of the 1st degree of severity of the right eye. In addition to standard ophthalmic examination methods, Doppler ultrasound with registration of blood flow in the orbital artery and spiral computed tomography of the ICA were performed. Results. Panretinal photocoagulation (PRP) of the retina led to obliteration of the retinal macroaneurysm, resorption of intraretinal hemorrhages, and stabilization of the course of CIR after CE of the ICA. Conclusion. The appearance of retinal macroaneurysm and intraretinal hemorrhages after CE in patient with CIR associated with hemodynamically significant ICA stenosis can be regarded as reperfusion complications after restoration of blood flow in the orbital artery, which requires timely retinal PRP of the retina. Key words: chronic ischemic retinopathy, retinal macroaneurysm, internal carotid artery, carotid endarterectomy.
Study of the effectiveness of antiangiogenic therapy for diabetic macular edema in avitreal eyes in real clinical practice
Authors:   Center of laser correction of the vision and microsurgery, Saratov, Ahmed K. A. , Semenova T.N. ,   Center of laser correction of the vision and microsurgery, Saratov, Soloveichik I.B. ,   Center of laser correction of the vision and microsurgery, Saratov, Arsyutov D.G. ,   Center of laser correction of the vision and microsurgery, Saratov, Maksimov V.Y. ,   Center of laser correction of the vision and microsurgery, Saratov
Published: August 2021

Despite the vitrectomy performed for diabetic macular edema (DME), some patients still have symptoms of the disease due to overproduction of VEGF by the ischemic retina, which requires regular administration of an antiangiogenic drug. Studies of the pharmacokinetics of antiangiogenic drugs after vitrectomy in humans have not been carried out. Data from the DRCR.net (Post-Hawk Protocol I) study and real-life clinical practice studies show similar results for anti-VEGF DMO therapy in vitreous eyes and after vitrectomy (2, 7). Purpose. To assess the effectiveness of antiangiogenic therapy with aflibercept for DMO in avitreal eyes in real clinical practice. Methods. The initial and after vitrectomy best corrected visual acuity (BCVA) and central retinal thickness (CRT) were determined according to OCT data, then these parameters were monitored by 1, 3, 6 and 12 months after the start of antiangiogenic therapy with aflibercept. 14 patients (14 eyes) with persistent DME underwent vitrectomy with removal of the internal limiting membrane, in 5 of them the epiretinal fibrosis was removed and 3 of them with a traction retinal detachment that was also removed with air tamponade. Results. Aflibercept intravitreal injections were started with 5 loading doses by 1-11 months after vitrectomy. On average, after 12 months, patients received 7.2 injections, while there was no need for laser surgery of the macular zone. By the end of the study, the CRT decreased by 255 ±86 µm, the BCVA was 0.35 ± 0.2 in comparison with the initial 0.07±0.03 (on a decimal scale). Conclusions. The effectiveness of the anti-VEGF therapy with aflibercept for DME in avitreal eyes was confirmed by an increase in functional (BCVA) and normalization of morphological (CRT on OCT) parameters after the first injections during the period of loading doses. Previous vitrectomies in patients with DMO do not affect the long-term favorable clinical outcomes of anti-VEGF therapy with aflibercept. Key words: vitrectomy, diabetic macular edema, aflibercept, anti-VEGF, OCT, best corrected visual acuity, central retinal thickness.
The role of intraocular hydrodynamics in inducing posterior hyaloid membrane detachment (preliminary report)
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Saint Petersburg branch, Zhogolev K.S. , Bayborodov Y.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Saint Petersburg branch
Published: August 2021

At present, it is believed that the detachment of the vitreous body occurs due to the contraction and liquefaction of the vitreous body, while the exit of the liquid part of the vitreum into the retrovitreal space passes passively through the formed prepapillary opening, after which the vitreous body collapses, however, more precise mechanisms have not been described. Purpose. Substantiate a hypothesis of influence of intravitreal hydrodynamics in inducing detachment of the posterior hyaloid membrane based on the analysis of OCT data. Material and methods. An OCT study was performed in 30 patients with initial detachment of the posterior hyaloid membrane (PHM) with macular adhesion, macular traction, and macular hole. The features of the location of the PHM in the region of the macula, foveola and the place of attachment of the PHM to the optic nerve were studied. Results and discussion. As a result of the analysis of OCT images, it was found that with macular holes, macular adhesion and macular traction, a closed space is formed between the posterior hyaloid membrane and the retina (subbursal space) in the form of a dome, which indirectly indicates an increase in pressure within this space. In 28 patients, the zone of dissection or thinning of the PHM was found parapapillary, through which the intraocular fluid is likely to be injected into the subbursal space. Conclusions: This study suggests the leading role of intravitreal hydrodynamics and the formation of an area of increased pressure in the subbursal space in the induction of the detachment of the PHM, the pathogenesis of vitreomacular adhesion, vitreomacular traction and macular hole. The topic requires more detailed study. Key words: posterior hyaloid membrane, OCT, vitreous body, macular hole.
OCT-indications for antiangiogenic therapy of macular edema in postthrombotic retinopathy
Authors:   State Budget Institution of Rostov region ", Kabardina E.V. ,   Rostov Regional Hospital",   , Rostov-on-Don, Russia, Shurygina I.P. ,   Federal State Budget Educational Institution of Higher Education Rostov state medical university Russian Ministry of Health, Rostov-on-Don, Russia
Published: August 2021

Purpose. To develop OCT-indications for antiangiogenic therapy of macular edema in post-thrombotic retinopathy. Material and methods. The study included 300 patients (121 women, 179 men) who had suffered upper temporal lobe thrombosis with macular edema in the period from 1 to 3 months and received antiangiogenic therapy. The age of the patients ranged from 42 to 73 years (the average age was 58.5±1.2 years). The duration of follow-up was 2 years. All patients underwent an OCT - study using the device "Heidelberg Spectralis" (Germany). We used a program for creating a map of the macular region with the interpretation of quantitative indicators of the macular region: height and volume. Results. According to the results of the study, a statistical analysis of the initial quantitative characteristics of macular edema in patients with positive dynamics of treatment with antiangiogenic therapy drugs was performed. As a result of the analysis, statistically significant values were identified: the thickness of the central zone of the retina and the average macular volume, which were used in the development of objective criteria, which allowed us to calculate the coefficient of indications for antiangiogenic therapy of macular edema in post-thrombotic retinopathy according to the author's formula (RF Patent No. 2706303). Conclusions. In the course of the conducted studies, the author's formula was proposed, which clarifies the reliability of OCT indications for the expediency of antiangiogenic therapy of macular edema in post-thrombotic retinopathy. Key words: intravitreal drugs, macular edema, post-thrombotic retinopathy, optical coherence tomography.
Results of treatment of penetrating wounds of the eyeball
Authors:   Ryazan State Medical University named after academician I.P. Pavlov, Russian Federation, Kolesnikov A.V. ,   N.A. Semashko Regional clinical hospital, Russian Federation, Kirsanova I.V. ,   Ryazan State Medical University named after academician I.P. Pavlov, Russian Federation,   N.A. Semashko Regional clinical hospital, Russian Federation, Averina M.M. ,   Ryazan State Medical University named after academician I.P. Pavlov, Russian Federation, Grishina T.D. ,   Ryazan State Medical University named after academician I.P. Pavlov, Russian Federation
Published: August 2021

Actuality. Trauma of the organ of vision still has been one of the most frequent causes of disability due to visual disorders leading to blindness, which determines the high socio-economic significance of this problem. In the structure of eye trauma, penetrating wounds make up from 67 to 84%. Timely and fully performed primary surgical treatment in combination with modern vitreoretinal surgery, according to indications, allows preserving the eyeball and even obtaining good functional results. Purpose. The aim of this work is to analyze the structure and outcomes of penetrating eye injuries in patients treated at the N.A. Semashko for 2015-2020. Material and methods. We carried out a retrospective analysis of the medical records of patients with penetrating wounds for 2015-2020. For five years in the regional clinical hospital named after N.A. Semashko, Ryazan, 142 patients aged 19 to 82 were hospitalized. Results. In the first hours after admission primary surgical debridement was done to 100% of patients. Also all patients were immediately started systemic and local detoxification and antibiotic therapy. Against the background of the treatment, the inflammatory process was arrested in 95.8% of patients, the average hospital stay was 6.8±2.5 days. An improvement in visual functions was observed in 52.1% of cases (74 eyes), visual acuity remained the same in 47 eyes (33.1%), and deterioration, up to complete loss of vision, in 21 eyes (14.8%). Conclusion. The results of the treatment of penetrating wounds depend both on the time and amount of care provided, and on the patient's age, the presence of complications and concomitant diseases, on the localization of the inlet, on the depth of penetration of a foreign body, and on many other factors. Key words: penetrating wound, vitrectomy, phacoemulsification, intraocular foreign body.
Analysis of antiangiogenic therapy in Retinal Angiomatous Proliferation
Authors:   Scientific Research Institute of Eye Diseases. Moscow, Shelankova A.V. , Afanasyeva M.A. ,   Scientific Research Institute of Eye Diseases. Moscow, Plyukhova A.A. ,   Scientific Research Institute of Eye Diseases. Moscow
Published: August 2021

Retinal angiomatous proliferation (RAP) is a separate form of neovascular age-related macular degeneration (nAMD), which accounts for 12-15% of newly diagnosed patients with nAMD [14]. It is believed that the development of RAP is associated with vascular endothelial growth factor (VEGF) [12]. Purpose. The main goal of our work was to conduct a retrospective analysis of the use of anti-VEGF therapy in patients with retinal angiomatous proliferation. Material and methods. Under observation in 14 patients (14 eyes) with retinal angiomatous proliferation. The age of the patients ranged from 52 to 80 years. The observation period was 4 years. OCT data were used to assess the presence / absence of neuroepithelial detachment, the presence / absence of retinal pigment epithelium detachment and the presence / absence of intraretinal fluid, and the incidence of RP rupture was assessed. Results. The maximally corrected visual acuity increased already in the first year of follow-up compared to BCVA before treatment, under the condition of intravitreal injections (IVI) of anti-VEGF drug aflibercept, and continued to remain at the same level throughout the observation period. In most patients, subretinal fluid was resorbed as early as 1 year of follow-up against the background of antiangiogenic therapy; by 3 years of follow-up, ONE remained only in 2 patients. Before treatment, 71.4% of patients had intraretinal fluid (IRF) in the macular zone according to OCT data; by the 3rd year of follow-up, the percentage of patients with IRF was 33.3%. Conclusion. In the course of this work, we have shown a positive effect of intravitreal administration of the anti-VEGF drug aflibercept in patients with retinal angiomatous proliferation. Key words: age-related macular degeneration, retinal angiomatous proliferation, anti- VEGF, macular edema.
The role of the macular interface in the diagnosis of retinopathy of prematurity and diabetic angioretinopathy
Authors:   Voronezh State Medical University named after N.N. Burdenko, Kovalevskaya M.A. , Pererva O.A. ,   Voronezh State Medical University named after N.N. Burdenko
Published: August 2021

Vitreomacular interface is an important part of the diagnosis from retinopathy of prematurity (ROP) to retinal diseases in adults. It is required to develop a method for macula localization to determine 3 stable points for photographic measurements of a 3D eye model. Purpose. To minimize the risk of mistakes in the diagnosis and choice of treatment for ROP and diabetic angioretinopathy (DARP) by improving the quality and analysis of modeled wide-field images on the Key to Diagnosis I and II platforms. Material and methods. 1278 RetCam and fundus images of 402 patients. 3 clinical groups: 1 – ROP 272 (544 eyes): 1A – I stage 152(304 eyes), 1B – II stage 45 (90 eyes), 1C – III stage 8 (12 eyes), 1D – posterior aggressive ROP 7 (14 eyes), 1E-retinal immaturity 60 (120 eyes); 2 – DARP 120 (240 eyes): 2A – non-proliferative 13 (17 eyes), 2B – preproliferative 47 (55 eyes), 2C – proliferative 27 (33 eyes), 2D – terminal 33 (37 eyes), 3 – control 10 (20 eyes). A standard clinical examination, analysis of modeled wide-field images, localization of the macula and traction index of the macular region (Tm) were performed. Results. Platform modules have been developed for automatic wide-field images modeling and macular localization, which is a reference point for assessing the extent of pathological changes. In ROP there was significant negative correlation of the Tm value with a stage: 1А – 0,8±0,03, 1B – 0,75±0,04, 1C – 0,74±0,13, 1D – 0,99±0,01, 1E – 0,91±0,09. For groups 2A – 2B, there was no correlation between Tm and the DARP severity. Conclusion. Tm reflects the severity of traction processes at the periphery of the retina and can be used as a marker in case of diagnostic defects in ROP. The localization of the macula determines the stable points for automatic morphometry. Key words: retinopathy of prematurity, pediatric retinal camera RetCam-Shuttle, telemedicine, diabetic angioretinopathy, vitreomacular interface.
Surgical treatment experience of a macular hole in the conditions of the Regional State ophthalmologic clinical hospital of Public Health Ministry of Udmurt Republic
Authors:   Regional State ophthalmologic clinical hospital of Public Health Ministry of Udmurt Republic, Izhevsk, Ivanov S.V. ,   Izhevsk State Medical Academy, Izhevsk, Perevozchikov P.A. ,   Regional State ophthalmologic clinical hospital of Public Health Ministry of Udmurt Republic, Izhevsk,   Izhevsk State Medical Academy, Izhevsk, Arefeva N.A. ,   Regional State ophthalmologic clinical hospital of Public Health Ministry of Udmurt Republic, Izhevsk, Samartsev V.S. ,   Regional State ophthalmologic clinical hospital of Public Health Ministry of Udmurt Republic, Izhevsk, Kronshtadtskaya A.Y. ,   Regional State ophthalmologic clinical hospital of Public Health Ministry of Udmurt Republic, Izhevsk
Published: August 2021

Purpose. To evaluate the effectiveness of surgical treatment of idiopathic macular hole in the conditions of the Regional State ophthalmologic clinical hospital of Public Health Ministry of Udmurt Republic. Methods. The study included 32 patients (32 eyes), 30 women, 2 men, aged 54 to 73 years with idiopathic macular hole. The patients were divided into three groups: the first – 8 people with a small diameter of macular hole (206.1±31.1 microns), the second – 8 people with a medium diameter of macular hole (333.5±53.6 microns), the third – 16 people with a large diameter of macular hole (564.7±96.6 microns). All of them underwent a 25-gauge vitrectomy with removal of the internal limiting membrane, drainage of the macular opening, instillation of 1-2 drops of platelet-rich autoplasma and subsequent air tamponade of the vitreal cavity. At the same time, the patients occupied a forced position of the body face down for the next 2 hours after the operation. Examinations were carried out before surgical treatment, at discharge from the hospital, 1 month and 1 year after the operation. Results. In the postoperative period, the closure of the macular hole was noted in 100 % of cases. In the first group, the visual acuity improved from 0.09±0.04 to 0.2±0.1 after 1 month and became 0.24±0.21 after 1 year after surgery (p < 0.05, U-test). In the second group, the visual acuity improved from 0.12±0.08 to 0.25±0.14 after 1 month and became 0.35±0.22 after 1 year after surgery (p<0.05, U-test). In the third group, the visual acuity improved from 0.08±0.05 to 0.13±0.05 after 1 month and became 0.16±0.15 after 1 year after surgery (p < 0.05, U-test). Conclusion. The results obtained indicate 100% effectiveness of the applied method of surgical treatment of macular hole, but to achieve even better results, it is necessary to search for new methods of treatment without removing the ILM. Key words: idiopathic macular hole, platelet-rich autoplasma, vitrectomy.
Surgical treatment of silicone glaucoma after successful rhegmatogenous retinal detachment surgery
Authors:   V.I. Vernadsky Crimean Federal University, Simferopol, Ivanova N.V. , Savchenko A.V. ,   V.I. Vernadsky Crimean Federal University, Simferopol, Litvinenko O.A. ,   Etel Co ltd, Simferopol
Published: August 2021

Белые ночи - 2021 Сателлитные симпозиумы в рамках XXVII Международного офтальмологического конгресса Грибковые поражения глаз Всероссийская научно-практическая конференция Грибковые поражения глаз Всероссийская научно-практическая конференция Sochi Cornea 2021 Всероссийская научно-практическая конференция с международным участием Конференция Sochi Cornea 2021 Всероссийская научно-практическая конференция с международным участием Пироговская офтальмологическая академия Пироговская офтальмологическая академия Актуальные вопросы офтальмологии. Круглый стол компании «Бауш Хелс» Актуальные вопросы офтальмологии. Круглый стол компании «Бауш Хелс» Лечение глаукомы: инновационный вектор. II Всероссийская научно-практическая конференция с международным участием Конференция Лечение глаукомы: инновационный вектор. II Всероссийская научно-практическая конференция с международным участием Роговица V Новые достижения и перспективы Конференция Роговица V Новые достижения и перспективы Научно-образовательные вебинары Научно-образовательные вебинары Сателлитные симпозиумы в рамках РООФ-2020 Сателлитные симпозиумы в рамках РООФ-2020 Расширенное заседание Экспертного Совета по проблемам глаукомы и группы «Научный авангард» Конгресс Расширенное заседание Экспертного Совета по проблемам глаукомы и группы «Научный авангард» Сателлитные симпозиумы в рамках XII Съезда Общества офтальмологов России Сателлитные симпозиумы в рамках XII Съезда Общества офтальмологов России Все видео... Red eye СИНДРОМ КРАСНОГО ГЛАЗА Источник Современные технологии в офтальмологии №3 2021 Раздел 1. Эндовитреальная хирургия Реферат RUS Реферат ENG Литература Полный текст УДК: DOI: https://doi.org/10.25276/2312-4911-2021-3-61-67 N.V. Ivanova, A.V. Savchenko, O.A. Litvinenko Surgical treatment of silicone glaucoma after successful rhegmatogenous retinal detachment surgery Медицинская академия имени С. И. Георгиевского Федерального государственного автономного образовательного учреждения высшего образования «Крымский федеральный университет имени В. И. Вернадского» "Компания "Этель" Abstract Surgical treatment of silicone glaucoma after successful rhegmatogenous retinal detachment surgery N.V. Ivanova, A.V. Savchenko, O.A. Litvinenko V.I. Vernadsky Crimean Federal University, Simferopol Etel Co ltd, Simferopol
Methods of correction of aphakia in silicone tamponade of the vitreous cavity
Authors:   National Medical and Surgical Center named after N. I. Pirogov, Ministry of Health of the Russian Federation, Karpov G.O. , Fayzrakhmanov R.R. ,   National Medical and Surgical Center named after N. I. Pirogov, Ministry of Health of the Russian Federation, Pavlovsky O.A. ,   National Medical and Surgical Center named after N. I. Pirogov, Ministry of Health of the Russian Federation, Sukhanova A.V. ,   National Medical and Surgical Center named after N. I. Pirogov, Ministry of Health of the Russian Federation
Published: August 2021

The purpose of this study is to conduct a comparative analysis of the correction of aphakia by various models of intraocular lenses using silicon oil tamponade (SO) of the vitreous cavity. Materials and methods. The studies were conducted on 16 eyes of patients aged from 56 to 75 years (65.5±12 years) with aphakia and pathology of the vitreal cavity. The duration of the silicone tamponade was 2-3 months. Depending on the use of the type of IOL, all patients were divided into 2 groups. Results. When using an anterior chamber intraocular lens (IOL), the presence of ophthalmic hypertension was revealed in 75% of cases, which is 2.02 times higher than when using transcleral IOL fixation. In 37.5% of cases, the SO output to the anterior chamber is determined, in contrast to the group where IOL hemming was used. A higher percentage of SO migration to the anterior chamber of the eye in group 2 patients is due to a violation of the anatomy of the anterior chamber barrier and the vitreal cavity. Conclusion. Thus, in patients who underwent transcleral IOL fixation, visual acuity is 2.1 times higher than in patients who were implanted with an anterior chamber IOL. Transcleral fixation of the IOL can form the necessary barrier between the anterior and posterior chambers of the eye, and is also the closest IOL position to the physiological one. Key words: intraocular lens, silicone oil, transcleral fixation.
On the creation of a new unified classification of the vitreomacular interface surgical pathology
Authors:   Eye clinic ", Miroshnikov V.V. ,   InterYUNA",   , Rostov-on-Don, Ivanishko Y.A. ,   Eye clinic "InterYUNA", Rostov-on-Don,   The Rostov State Medical University, Rostov-on-Don, Kovalev S.A. ,   Eye clinic "InterYUNA", Rostov-on-Don,   The Rostov State Medical University, Rostov-on-Don
Published: August 2021

The progress of modern methods the vitreomacular interface (VMI) visualization, clinical and histopathological studies are constantly expanding our understanding of the course of the macular pathological process. At the same time, the diagnostic and classification schemes we use may lose their relevance without reflecting the pathogenesis of the disease, complicating the choice of treatment tactics, and also complicating professional communication when we using various classification approaches. Aim. To offer our views on the possibility of creating a unified clinical classification of primary surgical pathology of VMI. Material and methods. Research papers related to the surgical pathology of VMI were analyzed. Results. The main role in the development of VMI pathology belongs to the vitreous body and the changes that occur in it, leading to posterior vitreous detachment (PVD). Pathological PVD is a variant of vitreomacular adhesion: vitreoschisis or separation of the entire thickness of the posterior cortex with the presence of local vitreoretinal fixation. In the first case, an epiretinal membrane (ERM) develops, which can progress to an ERM with macular pseudohole or to an ERM with foveoschisis. In the second case, pathological PVD is realized in vitreomacular traction (VMT). Depending on various factors, VMT can resolve both asymptomatically and with the formation of a defect in the retinal tissue, leading to outer lamellar macular hole (outer LMH) and the subsequent formation of a full-thickness macular hole (FTMH). If the traction does not cause strong changes, then it, disrupting the architectonics of the retina, triggers the processes leading to the LMH (which was previously called degenerative LMH), and it, in turn, in rare cases, can also become FTMH. Conclusions. We proposed the combined clinical classification scheme of VMI primary surgical pathology, which more fully reflects modern ideas about pathogenesis and allows, based on OCT data, to more clearly differentiate macular changes requiring a various surgical approach. Key words: PPV, vitreomacular interface, classification, VMT, epiretinal membrane, ERM, pseudohole, macular hole.
Studing of retinal photosensitivity using various methods of surgical treatment of unclosed macular holes
Authors:   FGBU ", Larina E.A. ,   NMHC im. N.I. Pirogova",   of the Ministry of Healthcare of the Russian Federation, Fayzrakhmanov R.R. ,   FGBU "NMHC im. N.I. Pirogova" of the Ministry of Healthcare of the Russian Federation, Pavlovskii O.A. ,   FGBU "NMHC im. N.I. Pirogova" of the Ministry of Healthcare of the Russian Federation, Shishkin M.M. ,   FGBU "NMHC im. N.I. Pirogova" of the Ministry of Healthcare of the Russian Federation
Published: August 2021

The main treatment for macular holes is vitrectomy with peeling of the internal limiting membrane, however, despite the rapid development of macular surgery, the percentage of negative anatomical results after primary surgery remains high. The aim of this work was to evaluate and compare the functional parameters of the central part of the retina using surgical techniques for blocking unclosed macular holes (creating a ILM-free flap in combination with silicone oil tamponade, or creating a ILM-free flap with the application of an ACP mass and tamponade with a gas-air mixture). Material and methods. This study involved 42 patients, the patients were divided into groups in accordance with the technique of reoperative intervention, all patients underwent microperimetry. Results. The retinal photosensitivity along the small radius in patients in the group with tamponade with a gas-air mixture is 1.11 times higher than in patients with silicone oil tamponade, 1.51 times higher in the middle radius, 1.53 times higher in the large radius. Conclusions. In the 2nd group the photosensitivity indicators were higher than in 1st group of patients with using silicone oil tamponade, which can be explained by the negative effect of silicone oil on the macular area. Key words: macular rupture, rigid, free flap, silicone oil, ACP mass, microperimetry.