bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures 1 - 13, Tables 1 - 8 from SHON Is a Novel Estrogen-Regulated Oncogene in Mammary Carcinoma That Predicts Patient Response to Endocrine Therapy
Authors: Jung Yewon , Abdel-Fatah Tarek M.A. , Chan Stephen Y.T. , Nolan Christopher C. , Green Andrew R. , Ellis Ian O. , Li Lili , Huang Baiqu , Lu Jun , Xu Bing , Chen Longxin , Ma Runlin Z. , Zhang Min , Wang Jingru , Wu ZhengSheng , Zhu Tao , Perry Jo K. , Lobie Peter E. , Liu Dong-Xu
Published: March 2023

PDF file - 1391K, Supplemental Methods Fig. S1. Characterization of a polyclonal anti-SHON antibody raised in rabbits. Fig. S2. Specificity of the rabbit SHON polyclonal antibody. Fig. S3. Forced expression of SHON transforms normal human breast epithelial cells in vitro. Fig. S4. Immunocytochemistry with affinity purified SHON antibody. Fig. S5: Microphotographs of SHON expression in normal and breast cancer tissues. Fig. S6 and S7:: Kaplan-Meier survival curves. Fig. S8. SHON is an estrogen inducible gene. Fig. S9. The effects of endogenous SHON depletion significantly on growth in 3D Matrigel. Fig. S10. Depletion of SHON decreased BCL-2 and NF-kB transcription and protein in MCF-7 cells. Fig. S11. Depletion of endogenous SHON by a second SHON siRNA significantly reduced cell proliferation, anchorage independent growth and migration/invasion in MCF-7 cells. Fig. S12. Oncogenic properties of SHON in T47D mammary carcinoma cells. Fig. S13. BCL2 and NF-κB mediate SHON oncogenicity in T47D cells. Table S1. Primer sequences used to detect gene specific transcripts by RT-PCR. Table S2: The sequences of the primers used for real-time PCR. Table S3: Expression of genes in MCF7-SHON relative to MCF7-Vec cells. Table S4. The sequence of oligonucleotides used to construct SHON siRNA in pSilencer 2.1-U6 hygro vector. Table S5. Clinicopathological characteristics of the whole cohort (n=1650). Table S6: Antigens, primary antibodies, clone, source, optimal dilution and scoring system used for each immunohistochemical marker. Table S7: Association between SHON expression and other clinicopathologic variables. Table S8: Multivariate analysis using Cox regression analysis confirms that SHON protein expression is independent prognostic factor.
Supplementary Movie 1 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Authors: Belaid Amine , Cerezo Michaël , Chargui Abderrahman , Corcelle–Termeau Elisabeth , Pedeutour Florence , Giuliano Sandy , Ilie Marius , Rubera Isabelle , Tauc Michel , Barale Sophie , Bertolotto Corinne , Brest Patrick , Vouret-Craviari Valérie , Klionsky Daniel J. , Carle Georges F. , Hofman Paul , Mograbi Baharia
Published: March 2023

AVI file - 718K, Video 1 (related to Fig. 2A) is a time-lapse recording showing the normal cell division of control wild-type (WT) cells. In the last frame, the daughter WT cells are outlined in white to help visualize their successful division.
Supplementary Figures and Figure Legends and Table from Integrin αvβ3 and Fibronectin Upregulate Slug in Cancer Cells to Promote Clot Invasion and Metastasis
Authors: Knowles Lynn M. , Gurski Lisa A. , Engel Charlotte , Gnarra James R. , Maranchie Jodi K. , Pilch Jan
Published: March 2023

PDF file, 893K, Supplementary table, figures, figure legends and methods Files in this Data Supplement: � Supplementary Movie 1 - WMV file, 12420 K. Live cell imaging (phase contrast, 10x) of 786-0 cells over 72 hours after embedding in fibrin. � Supplementary Movie 2 - WMV file, 11607 K. Live cell imaging (phase contrast, 10x) of MDA-MB-231 cells over 72 hours after embedding in fibrin. � Supplementary Table, Figures and Legends - PDF file, 893 K. Supplementary Table 1: Clinicopathological data of patients with RCC. Figure S1A: Colony formation of 786-0 and MDA-MB-231 cells. Figure S1B: Cell surface expression of integrin �v�3 analyzed by flow cytometry. Figure S2: Effect of integrin �1 and �3 knockdown. Figure S3: Tumor cell spreading on fibrinogen-coated surface. Figure S4: Effect of fibronectin knockdown. Figure S5: Effect of Slug knockdown or inhibition with the TGF-�RII inhibitor SB431542 (EMD Millipore).
Supplementary Methods from Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Authors: Lutz Norbert W. , Le Fur Yann , Chiche Johanna , Pouysségur Jacques , Cozzone Patrick J.
Published: March 2023

PDF file - 287K, Includes additional experimental procedures, algorithm and logarithm data, and equations used. Also includes supplementary references.
Supplementary Figure 6 from Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Authors: Lutz Norbert W. , Le Fur Yann , Chiche Johanna , Pouysségur Jacques , Cozzone Patrick J.
Published: March 2023

PDF file - 91K, Flowchart presenting the step-by-step procedure for calculating multiple pH heterogeneity parameters from 31P NMR spectra.
Supplementary Figure 4 from Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Authors: Lutz Norbert W. , Le Fur Yann , Chiche Johanna , Pouysségur Jacques , Cozzone Patrick J.
Published: March 2023

PDF file - 29K, Simulation of bimodal pH distributions by addition of computer-generated Gaussian curves.
Supplemental Excel Worksheet from Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Authors: Lutz Norbert W. , Le Fur Yann , Chiche Johanna , Pouysségur Jacques , Cozzone Patrick J.
Published: March 2023

XLSX file - 8061K, Contains four numbered calculation sheets for calculations of pH heterogeneity parameters, and also as templates that can be used directly for new calculations.
Supplementary Methods from Fusion-Derived Epithelial Cancer Cells Express Hematopoietic Markers and Contribute to Stem Cell and Migratory Phenotype in Ovarian Carcinoma
Authors: Ramakrishnan Mallika , Mathur Sandeep R. , Mukhopadhyay Asok
Published: March 2023

PDF file, 157K, Includes supplementary data regarding Viral transduction, Real-time PCR (including primers), Flow cytometry, and additional experimental methods.
Supplementary Figures from Fusion-Derived Epithelial Cancer Cells Express Hematopoietic Markers and Contribute to Stem Cell and Migratory Phenotype in Ovarian Carcinoma
Authors: Ramakrishnan Mallika , Mathur Sandeep R. , Mukhopadhyay Asok
Published: March 2023

PDF file, 1372K, Expression of CD45 in putative cancer stem cell and pro-migratory compartment of metastatic human EOC (S1); Surgical orthotopic tumor initiation in the ovary by transferring ID8-GFP cells (S2); Analysis of fusion in hemato-epithelial ID8-GFP cells from ascites (S3); Characterization of the fused ID8 cells (ascites) for hematopoietic markers and ex-vivo fused ID8 cells for ploidy (S4); Characterization of the fused ID8 cells for epithelial marker and CXCR4 expression (S5); Characterization of the hematopoietic-cancer cell hybrids in Lewis lung carcinoma model (S6).
Supplementary Figure Legends from Fusion-Derived Epithelial Cancer Cells Express Hematopoietic Markers and Contribute to Stem Cell and Migratory Phenotype in Ovarian Carcinoma
Authors: Ramakrishnan Mallika , Mathur Sandeep R. , Mukhopadhyay Asok
Published: March 2023

PDF file, 115K.
Supplementary Table 1 from An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors
Authors: West Alison C. , Mattarollo Stephen R. , Shortt Jake , Cluse Leonie A. , Christiansen Ailsa J. , Smyth Mark J. , Johnstone Ricky W.
Published: March 2023

PDF file - 52K, Median survival and statistical analysis of the therapeutic efficacy of HDACi in WT and immunocompromised mice.
Supplementary Figure 4 from An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors
Authors: West Alison C. , Mattarollo Stephen R. , Shortt Jake , Cluse Leonie A. , Christiansen Ailsa J. , Smyth Mark J. , Johnstone Ricky W.
Published: March 2023

PDF file - 92K, Supplementary Figure 4. Eμ-myc cells expressing a mutated IFN-gammaR respond to vorinostat by not IFN-gamma, and proliferation of Eμ-myc cells is not effected by IFN-gamma.
Supplementary Figures from Activation of MAPK Pathways due to DUSP4 Loss Promotes Cancer Stem Cell-like Phenotypes in Basal-like Breast Cancer
Authors: Balko Justin M. , Schwarz Luis J. , Bhola Neil E. , Kurupi Richard , Owens Phillip , Miller Todd W. , Gómez Henry , Cook Rebecca S. , Arteaga Carlos L.
Published: March 2023

PDF file, 392K, Correlation of DUSP4 gene expression and DUSP4 copy number across 444 breast cancer samples (S1); Cytokine array of conditioned media from MDA-231 cells after DUSP4 knockdown (S2); Upregulation of IL6 and IL8 after sustained shDUSP4 expression in MDA-231 cells (S3); MEK pathway inhibition limits mammosphere formation and self-renewal in MDA231 cells (S4); Association of genomic DUSP4 loss with p-cJUN expression in the TCGA data (S5); Chromatin Immunoprecipitation of ETS-1 at the IL8 promoter (S6); Mammosphere quantification of SUM159PT cells in the presence of alternative MEK inhibitors (S7); Inhibition of MEK and JNK increases the CD24+ population in BLBC cells (S8); Escape from long term enforced expression of DUSP4 in SUM159PT/pINDUCER-DUSP4 cells (S9).
Supplementary Figure S1 from Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity
Authors: Kwong Brandon , Gai S. Annie , Elkhader Jamal , Wittrup K. Dane , Irvine Darrell J.
Published: March 2023

Supplementary Figure S1 PDF file 55K, Fluorescence and ELISA analysis of Lip-�CD137 + Lip-IL-2Fc retention at tumor following i.t. injection
Supplemental methods and figure legends from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Authors: Munson Jennifer M. , Bellamkonda Ravi V. , Swartz Melody A.
Published: March 2023

Supplemental Methods and Legends PDF file - 97K, Supplemental methods and figure legends for the supplemental figures
Supplementary Figures from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase
Authors: Wang Xiaoping , Saso Hitomi , Iwamoto Takayuki , Xia Weiya , Gong Yun , Pusztai Lajos , Woodward Wendy A. , Reuben James M. , Warner Steven L. , Bearss David J. , Hortobagyi Gabriel N. , Hung Mien-Chie , Ueno Naoto T.
Published: March 2023

PDF file, 351K, Silencing endogenous TIG1 in SUM149 IBC cells inhibits cell proliferation (S1); Silencing endogenous TIG1 in KPL-4 IBC cells inhibits cell proliferation, migration, and invasion (S2); TIG1 depletion affects the growth of SUM149 cells in 3-dimensional culture (S3); Heat map of 19 selected candidates from 183 probe sets differentially expressed between SUM149 cells transfected with control siRNA and SUM149 cells transfected with siRNA targeting TIG1 (siTIG1)(S4); Representative images of crystal violet staining of migration and invasion assays for Axl-restored shTIG1-A cells (S5); TIG1 colocalized with Axl in KPL-4 cells (S6); SGI-7079 treatment inhibits the invasion of KPL-4 cells (S7).
Supplementary Figure 2 from Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma
Authors: Avan Amir , Caretti Viola , Funel Niccola , Galvani Elena , Maftouh Mina , Honeywell Richard J. , Lagerweij Tonny , Van Tellingen Olaf , Campani Daniela , Fuchs Dieter , Verheul Henk M. , Schuurhuis Gerrit-Jan , Boggi Ugo , Peters Godefridus J. , Würdinger Thomas , Giovannetti Elisa
Published: March 2023

PDF file - 276K, Comparative IHC staining in human samples and orthotopic tumor grafts.
Supplementary Table 1 from Hallmarks of Aromatase Inhibitor Drug Resistance Revealed by Epigenetic Profiling in Breast Cancer
Authors: Jansen Maurice P.H.M. , Knijnenburg Theo , Reijm Esther A. , Simon Iris , Kerkhoven Ron , Droog Marjolein , Velds Arno , van Laere Steven , Dirix Luc , Alexi Xanthippi , Foekens John A. , Wessels Lodewyk , Linn Sabine C. , Berns Els M.J.J. , Zwart Wilbert
Published: March 2023

PDF file - 55K, Supplementary Table S1 Patient and tumor characteristics of the discovery cohort.
Supplementary Figures 1 - 8 from Single Copies of Mutant KRAS and Mutant PIK3CA Cooperate in Immortalized Human Epithelial Cells to Induce Tumor Formation
Authors: Wang Grace M. , Wong Hong Yuen , Konishi Hiroyuki , Blair Brian G. , Abukhdeir Abde M. , Gustin John P. , Rosen D. Marc , Denmeade Samuel Ray , Rasheed Zeshaan , Matsui William , Garay Joseph P. , Mohseni Morassa , Higgins Michaela J. , Cidado Justin , Jelovac Danijela , Croessmann Sarah , Cochran Rory L. , Karnan Sivasundaram , Konishi Yuko , Ota Akinobu , Hosokawa Yoshitaka , Argani Pedram , Lauring Josh , Park Ben Ho
Published: March 2023

PDF file - 1480K, Figure S1. Double knock in clones have single mutant PIK3CA alleles and equivalent expression of mutant and wild type PIK3CA and form aberrant structures in 3D culture. Figure S2. DKI xenografts retain the same number of KRAS and PIK3CA alleles. Figure S3. Knock out of mutant PIK3CA affects tumorigenicity in nude mouse xenograft assays. Figure S4. DKI cell lines show phosphorylation of Akt and Erk in physiologic but not supra-physiologic concentrations of EGF. Figure S5. DKI cells have increased phosphorylation of S6 ribosomal protein but not 4E-BP1. Figure S6. DKI cells are sensitive to the MEK inhibitor U0126 but not to rapamycin and show differential effects on phosphorylation of Akt, Erk, p70S6K and p90RSK. Figure S7. Transgene expression of mutant PIK3CA cDNA with and without RBD mutations in MCF- 10A and KRAS G12V knock in cell lines. Figure S8. Pdk1 activity is increased in DKI cells.
Supplementary Figure 1 from Hallmarks of Aromatase Inhibitor Drug Resistance Revealed by Epigenetic Profiling in Breast Cancer
Authors: Jansen Maurice P.H.M. , Knijnenburg Theo , Reijm Esther A. , Simon Iris , Kerkhoven Ron , Droog Marjolein , Velds Arno , van Laere Steven , Dirix Luc , Alexi Xanthippi , Foekens John A. , Wessels Lodewyk , Linn Sabine C. , Berns Els M.J.J. , Zwart Wilbert
Published: March 2023

PDF file - 189K, Supplementary Figure S1 Overlap of binding events for the three markers in all tumors.
Supplementary documents from Stress-Response Protein RBM3 Attenuates the Stem-like Properties of Prostate Cancer Cells by Interfering with CD44 Variant Splicing
Authors: Zeng Yu , Wodzenski Dana , Gao Dong , Shiraishi Takumi , Terada Naoki , Li Youqiang , Vander Griend Donald J. , Luo Jun , Kong Chuize , Getzenberg Robert H. , Kulkarni Prakash
Published: March 2023

Supplementary documents - PDF file 122K, Supplementary methods and supplementary figures legends
Supplementary Methods from Vaccination for Invasive Canine Meningioma Induces In Situ Production of Antibodies Capable of Antibody-Dependent Cell-Mediated Cytotoxicity
Authors: Andersen Brian M. , Pluhar G. Elizabeth , Seiler Charles E. , Goulart Michelle R. , SantaCruz Karen S. , Schutten Melissa M. , Meints Joyce P. , O'Sullivan M. Gerard , Bentley R. Timothy , Packer Rebecca A. , Thomovsky Stephanie A. , Chen Annie V. , Faissler Dominik , Chen Wei , Hunt Matthew A. , Olin Michael R. , Ohlfest John R.
Published: March 2023

PDF file - 75K, Contains descriptions of two methods used to acquire clinical histology and T cell response data.
Supplementary Tables 1 - 3 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence
Authors: Angelini Pier Davide , Fluck Mariano F. Zacarias , Pedersen Kim , Parra-Palau Josep Lluís , Guiu Marc , Bernadó Morales Cristina , Vicario Rocio , Luque-García Antonio , Navalpotro Nerea Peiró , Giralt Jordi , Canals Francesc , Gomis Roger R. , Tabernero Josep , Baselga José , Villanueva Josep , Arribas Joaquín
Published: March 2023

XLSX file - 225K, Log2FC of the 1631 gene transcripts regulated in MCF7 Tet-Off/p95HER2 60 hours after doxycycline removal and log2FC of the same transcripts in MCF7 Tet-Off/HER2 cells under the same conditions; Log2FC of the 361 genes products upregulated in the secretome of MCF7 Tet-Off / p95HER2 cells after doxycycline removal; Log2FC of the 55 gene transcripts upregulated preferetially by p95HER2 and Log2FC of the same gene products upregulated in the secretome of MCF7 Tet-Off/p95HER2 cells afer doxycycline removal
Supplementary Figure 1 from Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial α5 Integrin
Authors: Cao Ying , Hoeppner Luke H. , Bach Steven , E Guangqi , Guo Yan , Wang Enfeng , Wu Jianmin , Cowley Mark J. , Chang David K. , Waddell Nicola , Grimmond Sean M. , Biankin Andrew V. , Daly Roger J. , Zhang Xiaohui , Mukhopadhyay Debabrata
Published: March 2023

PDF file - 101K, Supplemental Fig.1. The impact of NRP-2 knockdown on primary tumor growth. (A) Knockdown of NRP-2 by shRNA in 786O cells caused upregulation of NRP-1. (B & C) 2 x 106 control and NRP-2 knockdown 786-O (B) and A-498 cells (C) were subcutaneously injected into nude mice. There was no significant different in the tumor volume between the control and NRP-2 knockdown groups in both 786-O and A-498 cells.
Supplementary Figure 4 from Nkx2-8 Downregulation Promotes Angiogenesis and Activates NF-κB in Esophageal Cancer
Authors: Lin Chuyong , Song Libing , Gong Hui , Liu Aibin , Lin Xi , Wu Jueheng , Li Mengfeng , Li Jun
Published: March 2023

PDF file - 25K, Expression of Nkx2-8 mRNA in human ESCC.
Supplementary Table 3 from A Comparative Genomic Approach for Identifying Synthetic Lethal Interactions in Human Cancer
Authors: Deshpande Raamesh , Asiedu Michael K. , Klebig Mitchell , Sutor Shari , Kuzmin Elena , Nelson Justin , Piotrowski Jeff , Ho Shin Seung , Yoshida Minoru , Costanzo Michael , Boone Charles , Wigle Dennis A. , Myers Chad L.
Published: March 2023

XLS file, 4065K, This table contains information of all significant yeast synthetic sick or lethal interactions (Costanzo et al. 2010) between genes that are conserved in human based on InParanoid7 (Ostlund et al. 2010).
Supplementary Table 1 from Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma
Authors: Lyford-Pike Sofia , Peng Shiwen , Young Geoffrey D. , Taube Janis M. , Westra William H. , Akpeng Belinda , Bruno Tullia C. , Richmon Jeremy D. , Wang Hao , Bishop Justin A. , Chen Lieping , Drake Charles G. , Topalian Suzanne L. , Pardoll Drew M. , Pai Sara I.
Published: March 2023

XLSX file - 9K, IFN-g production from PD-1(+) and (-) TILs isolated from PD-L1 (+) and (-) HPV-HNSCCs; data corresponding to Figure 6B.
Supplementary Figure 2 from miR145 Targets the SOX9/ADAM17 Axis to Inhibit Tumor-Initiating Cells and IL-6–Mediated Paracrine Effects in Head and Neck Cancer
Authors: Yu Cheng-Chia , Tsai Lo-Lin , Wang Mong-Lien , Yu Chuan-Hang , Lo Wen-Liang , Chang Yun-Ching , Chiou Guang-Yuh , Chou Ming-Yung , Chiou Shih-Hwa
Published: March 2023

PDF file - 119K, Suppl. Fig 2. Depletion of Sox9/ADAM17 impairs TICs properties
Supplementary Table 3 from Enhanced Radiation Sensitivity in HPV-Positive Head and Neck Cancer
Authors: Kimple Randall J. , Smith Molly A. , Blitzer Grace C. , Torres Alexandra D. , Martin Joshua A. , Yang Robert Z. , Peet Chimera R. , Lorenz Laurel D. , Nickel Kwangok P. , Klingelhutz Aloysius J. , Lambert Paul F. , Harari Paul M.
Published: March 2023

XLSX - 49K, Antibodies, sources, and catalog numbers used throughout manuscript.
Supplementary Table 1 from Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer
Authors: Shiota Masaki , Bishop Jennifer L. , Nip Ka Mun , Zardan Anousheh , Takeuchi Ario , Cordonnier Thomas , Beraldi Eliana , Bazov Jenny , Fazli Ladan , Chi Kim , Gleave Martin , Zoubeidi Amina
Published: March 2023

PDF file - 47K, Effect of OGX-427 on circulating tumor cells.
Supplementary Figure Legend from Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer
Authors: Shiota Masaki , Bishop Jennifer L. , Nip Ka Mun , Zardan Anousheh , Takeuchi Ario , Cordonnier Thomas , Beraldi Eliana , Bazov Jenny , Fazli Ladan , Chi Kim , Gleave Martin , Zoubeidi Amina
Published: March 2023

PDF file - 94K
Supplementary Materials and Methods and Figure Legends and Figures from Combination of Antibody That Inhibits Ligand-Independent HER3 Dimerization and a p110α Inhibitor Potently Blocks PI3K Signaling and Growth of HER2+ Breast Cancers
Authors: Garrett Joan T. , Sutton Cammie R. , Kurupi Richard , Bialucha Carl Uli , Ettenberg Seth A. , Collins Scott D. , Sheng Qing , Wallweber Jerry , DeFazio-Eli Lisa , Arteaga Carlos L.
Published: March 2023

PDF file, 511K, Supplementary Figure 1. LJM716 and p110alpha inhibitor synergistically inhibit tumor cell growth. Supplementary Figure 2. HER3 antibody sensitizes cells to PI3Kalpha inhibitor in colony forming assays. Supplementary Figure 3. HER3 antibody sensitizes cells to PI3Kalpha inhibitor in three-dimensional growth assays. Supplementary Figure 4. LJM716, BYL719, or the combination of the two significantly reduce S473 P-AKT levels in vivo.
Supplementary Figure 2 from Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer
Authors: Shiota Masaki , Bishop Jennifer L. , Nip Ka Mun , Zardan Anousheh , Takeuchi Ario , Cordonnier Thomas , Beraldi Eliana , Bazov Jenny , Fazli Ladan , Chi Kim , Gleave Martin , Zoubeidi Amina
Published: March 2023

PDF file - 61K, Hsp27 targeting siRNA has similar effects on EMT as stable Hsp27 knockdown.
Supplementary Figure Legends from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: March 2023

PDF file, 96K.
Supplementary Figure 1 from Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer
Authors: Shiota Masaki , Bishop Jennifer L. , Nip Ka Mun , Zardan Anousheh , Takeuchi Ario , Cordonnier Thomas , Beraldi Eliana , Bazov Jenny , Fazli Ladan , Chi Kim , Gleave Martin , Zoubeidi Amina
Published: March 2023

PDF file - 48K, Hsp27 knockdown reduces cell invasion through matrigel.
Supplementary Table 1 from TR3 Modulates Platinum Resistance in Ovarian Cancer
Authors: Wilson Andrew J. , Liu Annie Y. , Roland Joseph , Adebayo Oluwafunmilayo B. , Fletcher Sarah A. , Slaughter James C. , Saskowski Jeanette , Crispens Marta A. , Jones Howard W. , James Samuel , Fadare Oluwole , Khabele Dineo
Published: March 2023

XLSX - 28K, Information regarding TR3 expression, tumor grade, Stage and histology, and clinical response in 209 ovarian cancer patients.
Supplementary Table 4 from DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer
Authors: Cao Jianzhong , Song Yongmei , Bi Nan , Shen Jie , Liu Wenyang , Fan Jing , Sun Guogui , Tong Tong , He Jie , Shi Yuankai , Zhang Xun , Lu Ning , He Yinghua , Zhang Hongyu , Ma Kelong , Luo Xiaoying , Lv Lei , Deng Hui , Cheng Jing , Zhu Jingde , Wang Luhua , Zhan Qimin
Published: March 2023

PDF file - 40K, ECOG Performance Status.
Supplementary Figure 5 from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: March 2023

PDF file, 325K, Data completing Figure 4.
Supplementary Table 3 from DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer
Authors: Cao Jianzhong , Song Yongmei , Bi Nan , Shen Jie , Liu Wenyang , Fan Jing , Sun Guogui , Tong Tong , He Jie , Shi Yuankai , Zhang Xun , Lu Ning , He Yinghua , Zhang Hongyu , Ma Kelong , Luo Xiaoying , Lv Lei , Deng Hui , Cheng Jing , Zhu Jingde , Wang Luhua , Zhan Qimin
Published: March 2023

PDF file - 116K, Association of the promoter methylation state, level of expression of the miR-886 gene with the clinical outcome in SCLC.
Supplementary Table 2 from DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer
Authors: Cao Jianzhong , Song Yongmei , Bi Nan , Shen Jie , Liu Wenyang , Fan Jing , Sun Guogui , Tong Tong , He Jie , Shi Yuankai , Zhang Xun , Lu Ning , He Yinghua , Zhang Hongyu , Ma Kelong , Luo Xiaoying , Lv Lei , Deng Hui , Cheng Jing , Zhu Jingde , Wang Luhua , Zhan Qimin
Published: March 2023

PDF file - 48K, Primers sequences used for BSP and methylation specific PCR analyses.
Supplementary Table 1 from DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer
Authors: Cao Jianzhong , Song Yongmei , Bi Nan , Shen Jie , Liu Wenyang , Fan Jing , Sun Guogui , Tong Tong , He Jie , Shi Yuankai , Zhang Xun , Lu Ning , He Yinghua , Zhang Hongyu , Ma Kelong , Luo Xiaoying , Lv Lei , Deng Hui , Cheng Jing , Zhu Jingde , Wang Luhua , Zhan Qimin
Published: March 2023

PDF file - 53K, The sequences for the four plasmids.
Supplementary Figure Legend from DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer
Authors: Cao Jianzhong , Song Yongmei , Bi Nan , Shen Jie , Liu Wenyang , Fan Jing , Sun Guogui , Tong Tong , He Jie , Shi Yuankai , Zhang Xun , Lu Ning , He Yinghua , Zhang Hongyu , Ma Kelong , Luo Xiaoying , Lv Lei , Deng Hui , Cheng Jing , Zhu Jingde , Wang Luhua , Zhan Qimin
Published: March 2023

PDF file - 77K
Supplementary Figure 10 from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: March 2023

PDF file, 187K, S-3B truncated for its LEO domain lost its protective capacities.
Supplementary Table 1 from Reg3β Deficiency Impairs Pancreatic Tumor Growth by Skewing Macrophage Polarization
Authors: Gironella Meritxell , Calvo Carlos , Fernández Anna , Closa Daniel , Iovanna Juan L. , Rosello-Catafau Joan , Folch-Puy Emma
Published: March 2023

PDF file, 57K, Primers used for real time qRT-PCR.
Supplementary Figure 1 from Nitric Oxide Production Upregulates Wnt/β-Catenin Signaling by Inhibiting Dickkopf-1
Authors: Du Qiang , Zhang Xinglu , Liu Quan , Zhang Xianghong , Bartels Christian E. , Geller David A.
Published: March 2023

PDF file - 100K, Expressions of iNOS, DKK1 and Beta-catenin in human cancer tissues. A, HE staining of human tissue specimen was obtained from 4 patients with colon cancer. Scale bars, 50 microM. B, P21 CIP1/WAF1 gene expression in colon cancer tissues was compared with normal adjacent tissues determined by qRT-PCR. C, Primary human breast cancer specimens were stained with the indicated antibodies specific to iNOS, DKK1 and Beta-catenin by immunofluorescent analysis. Scale bars, 20 microM.
Supplementary Figure 2 from A Classification Model for BRCA2 DNA Binding Domain Missense Variants Based on Homology-Directed Repair Activity
Authors: Guidugli Lucia , Pankratz Vernon S. , Singh Namit , Thompson James , Erding Catherine A. , Engel Christoph , Schmutzler Rita , Domchek Susan , Nathanson Katherine , Radice Paolo , Singer Christian , Tonin Patricia N. , Lindor Noralane M. , Goldgar David E. , Couch Fergus J.
Published: March 2023

PDF file - 3.9MB, Location of the non-pathogenic and intermediate variants in the mouse BRCA2-DSS1-ssDNA complex
Supplementary Figure Legend from Proinflammatory Homeobox Gene, ISX, Regulates Tumor Growth and Survival in Hepatocellular Carcinoma
Authors: Hsu Shih-Hsien , Wang Li-Ting , Lee King-Teh , Chen Yao-Li , Liu Kwei-Yan , Suen Jau-Ling , Chai Chee-Yin , Wang Shen-Nien
Published: March 2023

PDF file - 43K
Supplementary Material from Sox2 Requirement in Sonic Hedgehog-Associated Medulloblastoma
Authors: Ahlfeld Julia , Favaro Rebecca , Pagella Pierfrancesco , Kretzschmar Hans A. , Nicolis Silvia , Schüller Ulrich
Published: March 2023

Supplementary Material - PDF file 829K, Suppl. Figure 1: Complete early knockout of Sox2 in neural precursors does not affect overall cerebellar development. Suppl. Figure 2: Loss of Sox2 does not affect the immunophenotype of murine Shh-associated medulloblastoma. Suppl. Figure 3: Expression of SOX3 in human medulloblastomas. Suppl. Figure 4: Transduced cells are of neuronal origin. Suppl. Figure 5: Sox2-positive cells express neuronal markers after Shh acitvation
Supplementary Table 2 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program
Authors: Charafe-Jauffret Emmanuelle , Ginestier Christophe , Bertucci François , Cabaud Olivier , Wicinski Julien , Finetti Pascal , Josselin Emmanuelle , Adelaide José , Nguyen Tien-Tuan , Monville Florence , Jacquemier Jocelyne , Thomassin-Piana Jeanne , Pinna Guillaume , Jalaguier Aurélie , Lambaudie Eric , Houvenaeghel Gilles , Xerri Luc , Harel-Bellan Annick , Chaffanet Max , Viens Patrice , Birnbaum Daniel
Published: March 2023

PDF file - 56K, Table SII.CSC frequency in three independent PDXs (CRCM226 x, CRCM168 x, CRCM174 x).
Supplementary Figure 5 from ANTXR1, a Stem Cell-Enriched Functional Biomarker, Connects Collagen Signaling to Cancer Stem-like Cells and Metastasis in Breast Cancer
Authors: Chen Daohong , Bhat-Nakshatri Poornima , Goswami Chirayu , Badve Sunil , Nakshatri Harikrishna
Published: March 2023

PDF file, 6506K, H&E staining pattern of tumors derived from control and ANTXR1 knockdown cells.
Supplementary Figure Legends from NF-κB Regulates Radioresistance Mediated By β1-Integrin in Three-Dimensional Culture of Breast Cancer Cells
Authors: Ahmed Kazi Mokim , Zhang Hui , Park Catherine C.
Published: March 2023

PDF File - 55K, Legends for Supplemental Figures S1-S4.
Supplementary Figure 8 from Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway
Authors: Cortot Alexis B. , Repellin Claire E. , Shimamura Takeshi , Capelletti Marzia , Zejnullahu Kreshnik , Ercan Dalia , Christensen James G. , Wong Kwok-Kin , Gray Nathanael S. , Jänne Pasi A.
Published: March 2023

PDF file - 203K, Drug resistant PFR3+ and PFR5 cells exhibit loss of DUSP 6
Supplementary Figure 5 from Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway
Authors: Cortot Alexis B. , Repellin Claire E. , Shimamura Takeshi , Capelletti Marzia , Zejnullahu Kreshnik , Ercan Dalia , Christensen James G. , Wong Kwok-Kin , Gray Nathanael S. , Jänne Pasi A.
Published: March 2023

PDF file - 42K, IGFBP3 promoter methylation is present in the PFR3 and PFR5 cells
Supplementary Tables S1-S10 from Integration of High-Resolution Methylome and Transcriptome Analyses to Dissect Epigenomic Changes in Childhood Acute Lymphoblastic Leukemia
Authors: Busche Stephan , Ge Bing , Vidal Ramon , Spinella Jean-François , Saillour Virginie , Richer Chantal , Healy Jasmine , Chen Shu-Huang , Droit Arnaud , Sinnett Daniel , Pastinen Tomi
Published: March 2023

XLSX file - 370K, Annotation of CpG-site interrogating probes (S1); Summary of RNA-sequencing generated for each patient sample on the SOLiD 4 system (S2); Percentage of probes within a given cross-sample standard deviation (SD)-range for normal (N) and tumor (T) samples (S3); Tumor sample methylation level variability (S4); Amount of gene-associated CpG-sites, amount of RefSeq genes and their isoforms in each CpG-site region, and region-specific median Spearman's rho (S5); Spearman's ranked correlation rho between methylation and transcript expression level with significance level for each patient in each CpG-site region (S6); Probes displaying significant differential methylation in samples carrying the t(12;21) translocation (S7); Genes associated with t(12;21)-specifically methylated probes (S8); Genes identified as uniformely hypo- or hypermethylated in samples carrying the t(12;21) translocation, and associated methylation and transcript expression levels (S9); Gene networks generated by IPA (S10)
Supplementary Figure 1 from Gankyrin Activates IL-8 to Promote Hepatic Metastasis of Colorectal Cancer
Authors: Bai Zhaofang , Tai Yanhong , Li Weihua , Zhen Cheng , Gu Weiting , Jian Zhao , Wang Qianyi , Lin Jieru E. , Zhao Qing , Gong Weili , Liang Bing , Wang Chenguang , Zhou Tao
Published: March 2023

PDF file - 199K, Gankyrin is highly expressed in colorectal cancer.
Supplementary Table S4 from Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein
Authors: Dua Pooja , Kang Hye Suk , Hong Seung-Mo , Tsao Ming-Sound , Kim Soyoun , Lee Dong-ki
Published: March 2023

Supplementary Table S4 PDF file - 776K, Table S4. Gene expression data comprising of genes with >1.5 fold reduction in expression upon siRNA mediated ALPPL2 knockdown
Supplementary Figure S3 from Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein
Authors: Dua Pooja , Kang Hye Suk , Hong Seung-Mo , Tsao Ming-Sound , Kim Soyoun , Lee Dong-ki
Published: March 2023

Supplementary Figure S3 PDF file - 914K, Figure S3. SQ2(6-30)-TAMRA shows heterogenic binding to pancreatic adenocarcinoma cell lines
Supplementary Figure 1 from G-CSF Receptor Positive Neuroblastoma Subpopulations Are Enriched in Chemotherapy-Resistant or Relapsed Tumors and Are Highly Tumorigenic
Authors: Hsu Danielle M. , Agarwal Saurabh , Benham Ashley , Coarfa Cristian , Trahan Denae N. , Chen Zaowen , Stowers Paris N. , Courtney Amy N. , Lakoma Anna , Barbieri Eveline , Metelitsa Leonid S. , Gunaratne Preethi , Kim Eugene S. , Shohet Jason M.
Published: March 2023

PDF file - 1479K, Flow cytometry demonstrating specificity of CD114 staining and active binding of wild-type G-CSF ligand in both mouse and human neuroblastoma tumors.
Supplementary Methods from Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer
Authors: Park Dongkyoo , Magis Andrew T. , Li Rui , Owonikoko Taofeek K. , Sica Gabriel L. , Sun Shi-Yong , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Deng Xingming
Published: March 2023

PDF file, 31K.
Supplementary Figure 3 from Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer
Authors: Park Dongkyoo , Magis Andrew T. , Li Rui , Owonikoko Taofeek K. , Sica Gabriel L. , Sun Shi-Yong , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Deng Xingming
Published: March 2023

PDF file, 63K, Treatment of human lung cancer cells with BXI-72 results in Bcl-XL/Bax dissociation.
Supplementary Figure 2 from YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway
Authors: Pikor Larissa A. , Lockwood William W. , Thu Kelsie L. , Vucic Emily A. , Chari Raj , Gazdar Adi F. , Lam Stephen , Lam Wan L.
Published: March 2023

PDF file - 129K, Sensitivity to cisplatin and senescence occurs through a pathway other than just p53-p21.
Supplementary Figure 1 from MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma
Authors: Das Swadesh K. , Bhutia Sujit K. , Azab Belal , Kegelman Timothy P. , Peachy Leyla , Santhekadur Prasanna K. , Dasgupta Santanu , Dash Rupesh , Dent Paul , Grant Steven , Emdad Luni , Pellecchia Maurizio , Sarkar Devanand , Fisher Paul B.
Published: March 2023

PDF file - 275K, Characterization of stable shmda-9/syntenin and mda-9/syntenin clones.
Figure S3 from Growth of Triple-Negative Breast Cancer Cells Relies upon Coordinate Autocrine Expression of the Proinflammatory Cytokines IL-6 and IL-8
Authors: Hartman Zachary C. , Poage Graham M. , den Hollander Petra , Tsimelzon Anna , Hill Jamal , Panupinthu Nattapon , Zhang Yun , Mazumdar Abhijit , Hilsenbeck Susan G. , Mills Gordon B. , Brown Powel H.
Published: March 2023

Figure S3 - PDF file 1318K, Expression LPAR2 in breast cancers, and the importance of LPAR2 in the expression of cytokines in SUM159
Supplementary Table from Candidate Tumor Suppressor and pVHL Partner Jade-1 Binds and Inhibits AKT in Renal Cell Carcinoma
Authors: Zeng Liling , Bai Ming , Mittal Amit K. , El-Jouni Wassim , Zhou Jing , Cohen David M. , Zhou Mina I. , Cohen Herbert T.
Published: March 2023

PDF file, 110K, Comparison of an AKT1-regulated gene signature between high versus low Jade-1 expressing clear-cell RCC patient samples.
Supplementary Figure Legends from miR-205 Targets PTEN and PHLPP2 to Augment AKT Signaling and Drive Malignant Phenotypes in Non–Small Cell Lung Cancer
Authors: Cai Junchao , Fang Lishan , Huang Yongbo , Li Rong , Yuan Jie , Yang Yi , Zhu Xun , Chen Baixue , Wu Jueheng , Li Mengfeng
Published: March 2023

PDF file, 68K.
Supplementary Table 1 from The Multifaceted Role of the Microenvironment in Liver Metastasis: Biology and Clinical Implications
Authors: Van den Eynden Gert G. , Majeed Ali W. , Illemann Martin , Vermeulen Peter B. , Bird Nigel C. , Høyer-Hansen Gunilla , Eefsen Rikke Løvendahl , Reynolds Andrew R. , Brodt Pnina
Published: March 2023

PDF file 71K, Incidence of liver metastases in 10 common solid cancers based on findings at autopsy with references
Supplemental Data from Loss of LRIG1 Locus Increases Risk of Early and Late Relapse of Stage I/II Breast Cancer
Authors: Thompson Patricia A. , Ljuslinder Ingrid , Tsavachidis Spyros , Brewster Abenaa , Sahin Aysegul , Hedman Håkan , Henriksson Roger , Bondy Melissa L. , Melin Beatrice S.
Published: March 2023

The supplemental files provide details on the specific sub-studies used in the expression based replication analysis as well as detailed information on LRIG1 probe location on the MIP array and sensitivity analyses that were conducted relative to treatment type. Table 1. Gene expression data set description Table 2. Probe sets for LRIG1 and SLC25A26 Table 3. Datasets with available data for SLC25A26 and LRIG1 Supplemental Figure 1. LRIG1 segment lengths and probe count Supplemental Figure 2. LRIG1 gene and MIP probe location Supplemental Figure 3. Box plots of the entire cohort Supplemental Figure 4. Computed average overlap with LRIG1 across all samples. Supplemental Figure 5. observed no evidence for an association between the level of expression of SLC25A26 and DMFS
Supplementary Figure 6 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients
Authors: Levescot Anaïs , Flamant Stéphane , Basbous Sara , Jacomet Florence , Féraud Olivier , Anne Bourgeois Elvire , Bonnet Marie-Laure , Giraud Christine , Roy Lydia , Barra Anne , Chomel Jean-Claude , Turhan Ali , Guilhot François , Girard Jean-Philippe , Gombert Jean-Marc , Herbelin André
Published: March 2023

PDF file - 105KB, CML is associated with high circulating levels of soluble ST2: reversion after IM therapy.
Supplementary Figure 2 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients
Authors: Levescot Anaïs , Flamant Stéphane , Basbous Sara , Jacomet Florence , Féraud Olivier , Anne Bourgeois Elvire , Bonnet Marie-Laure , Giraud Christine , Roy Lydia , Barra Anne , Chomel Jean-Claude , Turhan Ali , Guilhot François , Girard Jean-Philippe , Gombert Jean-Marc , Herbelin André
Published: March 2023

PDF file - 192KB, CML-CP CD34(+) cells proliferate in response to IL-33.
Supplementary Figure 1 from Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy Is Dependent on ER-α Status
Authors: Harrison Hannah , Rogerson Lynsey , Gregson Hannah J. , Brennan Keith R. , Clarke Robert B. , Landberg Göran
Published: March 2023

PDF file - 6501K, Assessment of epithelial cell purity in primary samples
Supplementary Figure 6 from SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
Authors: Shin Dong Hoon , Choi Yong-Joon , Park Jong-Wan
Published: March 2023

PDF file 60KB, Cell viability in H1299 and A549
Supplementary Figure 10 from SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
Authors: Shin Dong Hoon , Choi Yong-Joon , Park Jong-Wan
Published: March 2023

PDF file 475K, Gross morphology of excised tumors
Supplementary Table 1 from Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem–like Cell Traits in Breast Cancer
Authors: Luo Man-Li , Gong Chang , Chen Chun-Hau , Lee Daniel Y. , Hu Hai , Huang Pengyu , Yao Yandan , Guo Wenjun , Reinhardt Ferenc , Wulf Gerburg , Lieberman Judy , Zhou Xiao Zhen , Song Erwei , Lu Kun Ping
Published: March 2023

PDF file - 35KB, Patient Information for Isolation of Lin-CD24-CD44+ Cells from Human Breast Cancer.
Supplementary Methods from Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem–like Cell Traits in Breast Cancer
Authors: Luo Man-Li , Gong Chang , Chen Chun-Hau , Lee Daniel Y. , Hu Hai , Huang Pengyu , Yao Yandan , Guo Wenjun , Reinhardt Ferenc , Wulf Gerburg , Lieberman Judy , Zhou Xiao Zhen , Song Erwei , Lu Kun Ping
Published: March 2023

PDF file - 34KB
Data Supplement from Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer
Authors: Endesfelder David , Burrell Rebecca A. , Kanu Nnennaya , McGranahan Nicholas , Howell Mike , Parker Peter J. , Downward Julian , Swanton Charles , Kschischo Maik
Published: March 2023

Supplementary Figure S5. Connectedness of copy number and prognostic signature expression. The absolute correlation coefficient between the copy number of the core regulators EXO1, PAQR4, TPX2 and UBE2C and the expression of each prognostic signature gene was averaged over all signature genes. The same connectedness value was computed for all the signature genes, excluding self correlations. Genes were ranked according to their connectedness.
Supplementary Material 2 from Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications
Authors: Grosse Laurent , Pâquet Sophie , Caron Patrick , Fazli Ladan , Rennie Paul S. , Bélanger Alain , Barbier Olivier
Published: March 2023

PDF file - 10741K, Supplementary material 2: Representative examples of immunoexpression obtained after incubation of prostate tissue microarrays with the anti-UGT2B15, anti-UGT2B17 or anti-vimentin antibodies.
Supplementary Figure Legend and Table 1 - 5 from A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer
Authors: Tang Kwan Ho , Dai Yong Dong , Tong Man , Chan Yuen Piu , Kwan Pak Shing , Fu Li , Qin Yan Ru , Tsao Sai Wah , Lung Hong Lok , Lung Maria L. , Tong Daniel K. , Law Simon , Chan Kwok Wah , Ma Stephanie , Guan Xin Yuan
Published: March 2023

DOC file - 322K, Supplemental Table 1. Primer sequences for real-time qPCR analyses. Supplemental Table 2. RPKM values of other reported CSC markers in the original 3 pairs of non-tumor (N) and ESCC (T) clinical samples (Patients #16, #18 and #19) used for RNA-Seq profiling. Supplemental Table 3. Cancer stem cell marker expression (CD90, CD44 and p75NTR / CD271) in a panel of ESCC cell lines. Supplemental Table 4. Clinicopathological correlation of CD44 and p75NTR / CD271 expression in ESCC. Supplemental Table 5. List of deregulated genes in CD90+ vs. CD90- cells in ESCC cells KYSE140 (cut off ≥ 3 folds).
Supplementary Video 5 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: March 2023

MOV file - 7443K, This video shows the spatio-temporal evolution of vSkin that produced Figure 6A (normal melanocytes and highly senescent fibroblasts).
Supplementary Figure S4 from mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis
Authors: Zhao Liqun , Yue Ping , Khuri Fadlo R. , Sun Shi-Yong
Published: March 2023

Supplementary Figure S4 PDF file - 256K, Both INK128 (A and C) and BEZ235 (B and D) decrease FLIPS levels (A and B) and synergy with TRAIL to kill cancer cells (C and D)
Supplementary Tables 1 and 2 from Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population
Authors: Laoui Damya , Van Overmeire Eva , Di Conza Giusy , Aldeni Chiara , Keirsse Jiri , Morias Yannick , Movahedi Kiavash , Houbracken Isabelle , Schouppe Elio , Elkrim Yvon , Karroum Oussama , Jordan Bénédicte , Carmeliet Peter , Gysemans Conny , De Baetselier Patrick , Mazzone Massimiliano , Van Ginderachter Jo A.
Published: March 2023

PDf - 36K, List of antibodies (S1); List of gene specific primers (S2).
Supplementary Methods from Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population
Authors: Laoui Damya , Van Overmeire Eva , Di Conza Giusy , Aldeni Chiara , Keirsse Jiri , Morias Yannick , Movahedi Kiavash , Houbracken Isabelle , Schouppe Elio , Elkrim Yvon , Karroum Oussama , Jordan Bénédicte , Carmeliet Peter , Gysemans Conny , De Baetselier Patrick , Mazzone Massimiliano , Van Ginderachter Jo A.
Published: March 2023

PDF - 49K, Description of additional methods and procedures used in the study. Also includes supplementary references.
Supplementary Video 3 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

AVI file - 970KB, Representative endogenous TPEF OPTICAL STACK HKcDR EETE.
Supplementary Figure 6 from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: March 2023

PDF file - 2142K, Spheroids of human GSC lines.
Supplementary Figure 2 from FOXC2 Expression Links Epithelial–Mesenchymal Transition and Stem Cell Properties in Breast Cancer
Authors: Hollier Brett G. , Tinnirello Agata A. , Werden Steven J. , Evans Kurt W. , Taube Joseph H. , Sarkar Tapasree Roy , Sphyris Nathalie , Shariati Maryam , Kumar Sreedevi V. , Battula Venkata L. , Herschkowitz Jason I. , Guerra Rudy , Chang Jeffrey T. , Miura Naoyuki , Rosen Jeffrey M. , Mani Sendurai A.
Published: March 2023

Supplementary Figure 2 PDF File - 600K, Ectopic expression of FOXC2 induces EMT in transformed human mammary epithelial cells (HMLER). (a) Quantification of EMT marker mRNA expression by quantitative real-time PCR analysis. Data is represented as the expression of EMT markers in HMLER-FOXC2 (FOXC2) cells relative to HMLER-Vector control cells (Vector). GAPDH was used as an internal normalization control. Columns indicate the mean (n = 3); error bars indicate SEM. (b) Western blot analysis of EMT marker protein expression upon FOXC2 overexpression in HMLER cells. Actin was used as a loading control. (c) Phase contrast and immunofluroescence images of HMLER-Vector and HMLER-FOXC2 cells. Overlayed images are shown for respective EMT markers (red) and DAPI nuclear stain (blue). Scale bar indicates 50 �m
Supplementary Table S3 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: March 2023

XLS file - 34K,Binding sites (c-MYCBSs) within the 2000bp promoter upstream of the CHK1 and CHK2 genes