bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptation of 3D-Printed and Milled Titanium Custom Post and Core
Authors: Alzaid Abdulaziz A. , Bukhari Sarah , Kattadiyil Mathew T. , Alqarni Hatem , AlHelal Abdulaziz A. , Alanazi Khalid K. , Suprono Montry S. , Jekki Rami , Sahl Erik F.
Published: December 2024

Background/Objectives: The purpose of this in vitro study was to evaluate and compare the internal adaptation and cement film thickness of cast-gold custom post and core (CPC), three-dimensionally (3D)-printed titanium (Ti) CPC, and milled Ti CPC. Methods: Forty-eight 3D printed resin models, simulating a tooth prepared to receive a CPC, were fabricated. Models were randomly assigned to one of three groups (n = 16 per group): (A) cast-gold CPC (control group), (B) 3D-printed Ti CPC, and (C) milled Ti CPC. Following the manufacturing of CPCs, each CPC was cemented using dual-cure polymerizing resin cement. Then, each model/post-and-core assembly was sectioned at the coronal, middle, and apical thirds of the post at a specific point. Each section was photographed using a microscope in a standardized setting (25×). The pixel count for cement surface area was calculated for each image using Adobe Photoshop software. Descriptive statistics of the mean and standard deviation of the cement film thickness around posts were calculated. Kruskal–Wallis and Dwass–Steel–Critchlow–Fligner tests were used for statistical analysis, with a significance level of α = 0.05. Results: Pairwise comparisons in the coronal section revealed a statistically significant difference (p < 0.05) between groups A and B and groups B and C. In the middle section, there was a statistically significant difference (p < 0.05) between groups A and B only. In the apical section, there was a statistically significant difference (p < 0.05) between all groups. Conclusions: Within the limitation of the present study, neither 3D printed nor milled Ti CPC could achieve comparable cement film thickness to cast-gold CPC in all three sections. Cast-gold CPC cement film thickness was found to be more reduced and consistent, thus having superior internal adaptation to 3D-printed and milled Ti CPCs.
AI-Enhanced Analysis to Investigate the Feasibility of EMG Signals for Prosthetic Hand Force Control Incorporating Anthropometric Measures
Authors: Joshi Deepak Chandra , Kumar Pankaj , Joshi Rakesh Chandra , Mitra Santanu
Published: December 2024

Background/Objectives: The potential application of electromyography (EMG) as a method for precise force control in prosthetic devices is investigated, expanding on its traditional use in gesture detection. Variability in EMG signals among individuals is influenced by physiological factors such as muscle mass, body fat percentage, and subcutaneous fat, as well as demographic variables like age, gender, height, and weight. This study aims to evaluate how these factors impact EMG signal quality and force output. Methods: EMG data was normalized using the maximum voluntary contraction (MVC) method, recorded at 100%, 50%, and 25% of MVC with simultaneous grip force measurement. Physiological parameters, including fat percentage, subcutaneous fat, and muscle mass, were analyzed. An extreme gradient boosting algorithm was applied to model the relationship between EMG amplitude and grip force. Results: The findings demonstrated significant linear correlations, with r2 coefficients reaching up to 0.93 and 0.83 in most cases. Muscle mass and fat levels were identified as key determinants of EMG variability, with significance coefficients ranging from 0.36592 to 0.0856 for muscle mass and 0.281918 to 0.06001 for fat levels. Conclusions: These results underscore the potential of EMG to enhance force control in prosthetic limbs, particularly in tasks such as grasping, holding, and releasing objects. Incorporating body composition factors into EMG-based prediction algorithms offers a refined approach to improving the precision and functionality of prosthetic control systems for complex motor tasks.
Enhancing Energy Efficiency in Integrated Electrolyser Stack and Methanation Reactor Systems Through Pinch Analysis
Authors: Oliveira Miguel , Borges Amadeu D. S.
Published: December 2024

This study uses the application of Pinch analysis to optimize an integrated electrolyzer and methanation system, a promising approach for producing green hydrogen and synthetic natural gas (SNG). By leveraging renewable energy sources, such as wind and solar, electrolysis is used to produce hydrogen, which reacts with captured carbon dioxide in the methanation reactor to form methane. This process not only allows for efficient energy storage but also supports the reduction of greenhouse gas emissions. A key focus of this study is the optimization of thermal energy flows within the system, which has not been extensively addressed in the literature. Pinch analysis was applied to identify the critical Pinch point, which revealed the temperature at which the most efficient heat recovery could be achieved. The design of a tailored heat exchanger network led to significant improvements, including a 66.45% reduction in hot utility consumption and an 18.85% reduction in cold utility demand. Overall, the system achieved global energy savings of 31.02%. These results were compared with the existing literature, demonstrating that our approach offers comparable or superior utility savings while addressing challenges, such as the complexity of chemical reactions and system integration. This research highlights the potential for substantial operational cost reductions and increasing sustainability in industrial applications, contributing to the advancement of renewable energy technologies and the decarbonization of energy systems.
Instant Degradation of Organic Dyes in Contaminated Rivers Using Iron-Doped Zinc Quaternary-Based Quantum Dots Nanocatalyst
Authors: Mgedle Nande , Oluwafemi Oluwatobi Samuel
Published: December 2024

Organic dyes such as methylene blue (MB) and rhodamine 6G (Rh 6G), when dissolved in water, pose a serious threat to the environment, humans, and aquatic life. In this study, we report the synthesis of Fe-doped ZnCuInS/ZnS core/shell quantum dots (FeZCIS/ZnS QDs) in aqueous solution by varying the iron concentrations (0%, 1%, 3%, 5%, 7%, and 10%) for the instant removal of these organic pollutants in contaminated water. The as-synthesized FeZCIS/ZnS QDs were negatively charged and spherical in shape with a diameter of 2.97 nm ± 0.73 nm. Furthermore, it showed improved quantum yield (QYs) compared to the undoped with an average lifetime of 37.15 ns (3% Fe-doped QDs). The undoped ZCIS/ZnS QDs showed percentage removal efficiency of 94.42% and 93.97% for MB and Rh 6G in contaminated deionized water, respectively, and 90.73% (MB) and 1.28% (Rh 6G), respectively, in contaminated rivers. However, the 3% FeZCIS/ZnS QDs showed a percentage removal efficiency of 99.94% and 95.79% for MB and Rh 6G in contaminated deionized water, respectively, and 91.42% and 11.11%, respectively, in rivers contaminated with the dyes. Increasing the concentration of the nanocatalyst to 4 mg/mL improved the removal efficiency of Rh 6G in contaminated rivers to 93.28% and 94.40% using ZCIS/ZnS QDs and FeZCIS/ZnS QDs, respectively.
Capture and UV-Fluorescence Characterization of Primary Aerosols Ejected During the Fast Pyrolysis of Biomass in a Hot Plate Reactor
Authors: Sánchez Mario A. , Orrego-Restrepo Estefanía , Bustamante-Durango Mariana , Maya Juan C. , Chejne Farid , Pecha Brennan , Quinchía-Figueroa Adriana M.
Published: December 2024

This study focuses on the collection and UV characterization of the bio-oil phase from primary aerosols ejected from the liquid intermediate phase during the fast pyrolysis of biomass in a hot plate reactor. The effects of the reactor pressure and aerosol-collecting surface temperature on the bio-oil yield and characteristics were evaluated. The study found that lower reactor pressures and a lower temperature of the collecting surface significantly enhanced the aerosol yield (up to 85%). UV-fluorescence was employed to assess the influence of these parameters on the light-to-heavy compound ratio (monomers vs. oligomers). The heavy fraction of bio-oil from the hot plate reactor was predominantly composed of dimers and trimers (340–370 nm), similar to pyrolytic lignin and the heavy fraction of the bio-oil, which also showed peaks in this range. In contrast, pyrolysis oils from auger and fluidized bed reactors displayed two peaks in the UV spectrum, with a maximum around 300 nm, indicating that they are mainly composed of light monomeric compounds. The UV characterization of the primary aerosols and the comparison with the UV spectra of the bio-oil and its fractions (light and heavy fraction and pyrolignin) revealed similar UV prints, highlighting the importance of aerosol ejection in the final composition of bio-oil.
A Hydrometallurgical Process for the Recovery of Noble Metals (Au, Pt, Ir, and Ta) from Pyrolyzed and Acid-Digested Solutions of Single-Use Medical Devices
Authors: Lampou Angeliki , Kokkinos Evgenios , Prochaska Charikleia , Tsiogkas Theodosios , Peleka Effrosyni , Xenidis Anthimos , Zouboulis Anastasios
Published: December 2024

Developing an efficient recycling route for spent single-use medical devices is essential for recovering precious metals. The proposed complete hydrometallurgical route goes through the initial pyrolysis and acid digestion steps, expanding upon our previous relevant work in the field, followed by solvent extraction, stripping, and precipitation procedures. In this study, a complete hydrometallurgical process was developed for the recovery of gold, platinum, iridium, and tantalum, separating them from other metals, i.e., from iron, chromium, and nickel, also present in the examined medical devices, i.e., (i) diagnostic electrophysiology catheters, containing gold, (ii) diagnostic guide wires, containing platinum and iridium alloys, and (iii) self-expanding stents, containing tantalum. This study reports the experimental results of selecting an efficient extractant, stripping, and precipitation agent, along with the effects of key factors that influence each consecutive step of the process, i.e., agent concentration, aqueous to organic phase ratio, contact time, and pH, using simulated metal solutions and also applying the obtained optimal conditions to the treatment of real sample solutions. For the selective separation of gold, Aliquat 336 was used to extract it in the organic phase; it was then stripped using a thiourea solution and precipitated by utilizing an iron sulfate (II) solution and proper pH adjustment. The selective separation of platinum was achieved by using Aliquat 336 for the organic phase extraction and a perchlorate acid solution for stripping it back into the aqueous solution and adding a sodium bromate solution to precipitate it. Due to the similar chemical behavior, the selective recovery of iridium followed the same processes as that of platinum, and the separation between them was achieved through selective precipitation, as heating the solution and adjusting the pH value resulted in the selective precipitation of iridium. Lastly, the selective recovery of tantalum consists of extraction by using Alamine 336, then stripping it back to the aqueous phase by using sodium chloride, and precipitation by using potassium salt solution and proper pH adjustment. A total recovery of 88% for Au, 86% for Pt, 84% for Ir, and 80% for Ta was obtained, thus achieving a high uptake of precious metals from the examined real spent/waste samples.
Diode Laser with Scaling and Root Planing for Treating Generalized Periodontitis: Case Report and Analysis of the Relevant Literature
Authors: Tene Teodora , Fratila Anca Maria , Arcas Vasile Calin , Sava Mihai , Roman-Filip Corina
Published: December 2024

This study evaluates the effectiveness of diode laser therapy, specifically the Biolase Epic X at 940 nm and 0.8–1 W, in conjunction with scaling and root planing (SRP) for treating generalized periodontitis. Background and Clinical Significance: A 32-year-old man underwent full-mouth disinfection and laser-assisted periodontal therapy, with follow-up at six months. Case Presentation: Significant improvements were observed, including reductions in bleeding on probing from 20% to 5%, in mean probing depth from 2.3 mm to 2.1 mm, and in clinical attachment level from −2.8 mm to −2.2 mm. Radiographic analysis showed a stabilization of bone loss and an 80% improvement in pathological sites. Conclusions: These findings indicate that diode laser therapy is an effective adjunct to SRP, enhancing periodontal health outcomes with minimal post-operative complications.
Usefulness of Point-Of-Care Ultrasound in Diagnosing and Managing Pediatric Multidistrict Chylous Effusion
Authors: Bellini Tommaso , Bustaffa Marta , Crocco Marco , Casabona Federica , Iovinella Giorgia , Malerba Federica , D’Alessandro Matteo , Piccotti Emanuela
Published: December 2024

Background and Clinical Significance: The use of point-of-care ultrasound (POCUS) in emergency departments is rapidly growing due to its ability to provide immediate and accurate diagnostic information at the bedside. Furthermore, it can provide precise and rapid information on the location of multidistrict effusions in patients with suspected lymphatic decompensation. Case Presentation: This unique clinical case report describes a patient who presented with massive, multidistrict chylous effusion secondary to acute lymphatic insufficiency, a rare and challenging condition. Due to a recent diagnosis of celiac disease, the patient had started a gluten-free diet ten days before the onset of symptoms, suggesting a possible causal link. Through comprehensive thoracoabdominal POCUS, the diagnosis was made promptly, avoiding delays in treatment and enabling timely decision-making. Conclusions: This case emphasizes the critical role of POCUS not only in expediting diagnosis but also in guiding invasive procedures, such as thoracentesis, by visualizing fluid accumulation and anatomical structures in real-time. Moreover, POCUS provides an invaluable tool for ongoing clinical ultrasound follow-up, facilitating continuous monitoring without exposing the patient to the risks of radiation, thus optimizing patient care and resource utilization.
The Road Well Traveled: From Inflammasomes to Collagen Export During Fibrosis
Authors: Artlett Carol M.
Published: December 2024

Collagen export from the endoplasmic reticulum is required for normal tissue homeostasis, and yet, in fibrotic disorders, this process is significantly upregulated. In this review, we will focus on the signaling cascade from the inflammasome and how that promotes collagen via proinflammatory/profibrotic cytokines. Concordantly, these cytokines also induce the expression of TANGO1 to cope with the increased movement of collagen through the endoplasmic reticulum. In normal and fibrotic cells, this pathway is finely tuned to meet the necessary demand in collagen export. Currently, the role of TANGO1 in fibrotic disorders and how the inflammasome induces its expression is not well understood. In this review, we will assimilate the current information concerning inflammasome activation and how it induces TANGO1 expression, leading to fibrosis.
Demystifying DFT-Based Harmonic Phase Estimation, Transformation, and Synthesis
Authors: Oliveira Marco , Santos Vasco , Saraiva André , Ferreira Aníbal
Published: December 2024

Many natural signals exhibit quasi-periodic behaviors and are conveniently modeled as combinations of several harmonic sinusoids whose relative frequencies, magnitudes, and phases vary with time. The waveform shapes of those signals reflect important physical phenomena underlying their generation, requiring those parameters to be accurately estimated and modeled. In the literature, accurate phase estimation and modeling have received significantly less attention than frequency or magnitude estimation. This paper first addresses accurate DFT-based phase estimation of individual sinusoids across six scenarios involving two DFT-based filter banks and three different windows. It has been shown that bias in phase estimation is less than 0.001 radians when the SNR is equal to or larger than 2.5 dB. Using the Cramér–Rao lower bound as a reference, it has been demonstrated that one particular window offers performance of practical interest by better approximating the CRLB under favorable signal conditions and minimizing performance deviation under adverse conditions. This paper describes the development of a shift-invariant phase-related feature that characterizes the harmonic phase structure. This feature motivates a new signal processing paradigm that greatly simplifies the parametric modeling, transformation, and synthesis of harmonic signals. It also aids in understanding and reverse engineering the phasegram. The theory and results are discussed from a reproducible perspective, with dedicated experiments supported by code, allowing for the replication of figures and results presented in this paper and facilitating further research.
Leveraging 3D Printing for Resilient Disaster Management in Smart Cities
Authors: Kantaros Antreas , Petrescu Florian Ion Tiberiu , Brachos Konstantinos , Ganetsos Theodore , Petrescu Nicolae
Published: December 2024

This work explores the transformative impact of 3D printing technology and disaster management within the context of smart cities. By evaluating various 3D printing technologies, such as desktop and large-scale printers, this research highlights their application in rapidly producing customized structures and essential supplies infrastructure components. Methods included the review of existing technologies, practical application in disasters scenarios. and the analysis of community engagement programs that enhance local preparedness and resilience through 3D printing. Case studies illustrate the significant benefits of integrating 3D printing technologies in disaster management. Findings indicate that while 3D printing offers rapid production and efficiency, disabilities such as high initial cost, regulatory issues, and the need for skilled operators must be addressed. This study concludes that with strategic collaboration and investment in the education and regulatory frameworks, 3D printing can significantly enhance urban resilience and sustainability, making it an invaluable tool for future smart cities. This research underscores the potential of 3D printing to significantly aid disaster management practices, fostering more adaptive and efficient urban environments.
A New Methodology for Estimating the Potential for Photovoltaic Electricity Generation on Urban Building Rooftops for Self-Consumption Applications
Authors: Villa-Ávila Edisson , Arévalo Paul , Ochoa-Correa Danny , Villa-Ávila Michael , Sempértegui-Moscoso Emilia , Jurado Francisco
Published: December 2024

As the world increasingly embraces renewable energy as a sustainable power source, accurately assessing of solar energy potential becomes paramount. Photovoltaic (PV) systems, especially those integrated into urban rooftops, offer a promising solution to address the challenges posed by aging energy grids and rising fossil fuel prices. However, optimizing the placement of PV panels on rooftops remains a complex task due to factors like building shape, location, and the surrounding environment. This study introduces the Roof-Solar-Max methodology, which aims to maximize the placement of PV panels on urban rooftops while avoiding shading and panel overlap. Leveraging geographic information systems technology and 3D models, this methodology provides precise estimates of PV generation potential. Key contributions of this research include a roof categorization model, identification of PV-ready rooftops, optimal spatial distribution of PV panels, and innovative evaluation technology. Practical implementation in a real urban setting demonstrates the methodology’s utility for decision making in the planning and development of solar energy systems in urban areas. The main findings highlight substantial potential for PV energy generation in the studied urban area, with capacities reaching up to 444.44 kW. Furthermore, implementing PV systems on residential rooftops has proven to be an effective strategy for reducing CO2 emissions and addressing climate change, contributing to a cleaner and more sustainable energy mix in urban environments.
Bridging Community Engagement and Technological Innovation for Creating Smart and Resilient Cities: A Systematic Literature Review
Authors: Kangana Nuwani , Kankanamge Nayomi , De Silva Chathura , Goonetilleke Ashantha , Mahamood Rifat , Ranasinghe Daneesha
Published: December 2024

Urbanization presents significant challenges to disaster management as cities grow and develop, hence increasing their vulnerability to disasters. Disaster resilience is crucial for protecting lives and infrastructure, ensuring economic stability, promoting equality and cohesion, and ensuring the long-term viability of metropolitan regions in these rapidly growing cities. This paper investigates contemporary approaches to creating smart and resilient urban environments through disaster management that emphasize community-based solutions in prioritizing advanced technologies. The key findings of the research include three factors to be accomplished in utilizing technology in community-based disaster management, trust in the crowd, digital divide, and cultural sensitivity. Moreover, the review highlights the significance of the use of smart technologies in improving urban resilience, including but not limited to real-time data-sharing platforms and ML algorithms. Furthermore, it emphasizes the challenges regarding reliability and accuracy in crowdsourced information, stressing the importance of user awareness.
Optimized E-Mobility and Portable Storage Integration in an Isolated Rural Solar Microgrid in Uganda
Authors: Kakande Josephine Nakato , Philipo Godiana Hagile , Krauter Stefan
Published: December 2024

This work analyses load profiles for East African microgrids, and then investigates the integration of electric two-wheelers and portable storage into a solar PV with battery microgrid in Uganda, East Africa. By introducing e-mobility and portable storage, demand side management strategic load growth can thus be achieved and electricity access can be expanded. Battery degradation is also considered. The results showed a 98.5% reduction in PV energy curtailment and a 57% reduction in the levelized cost of energy (LCOE) from 0.808 USD/kWh to 0.350 USD/kWh when the electric two-wheeler and portable storage loads were introduced. Such reductions are important enablers of financial viability and sustainability of microgrids. It is possible to avoid emissions of up to 73.27 tons of CO2/year with the proposed e-bikes, and an average of 160 customers could be served annually as off-microgrid consumers without requiring an investment in additional distribution infrastructure. Annual revenue could be increased by 135% by incorporating the additional loads. Sensitivity analyses were conducted by varying component costs, the battery lifetime, the interest rate, and the priority weighting of the additional loads. The battery costs were found to be a major contributor to lifecycle costs (LCC) and also have a big impact on the LCOE. The interest rate significantly affects the LCC as well.
The Efficacy of Pelvic Floor Rehabilitation in the Treatment of Urinary Incontinence in Female Athletes: A Systematic Review
Authors: Demeco Andrea , Bartocci Giulia , Astore Noemi , Vignali Beatrice , Salerno Antonello , Palermi Stefano , Foresti Ruben , Martini Chiara , Costantino Cosimo
Published: December 2024

Background and Objectives: Urinary incontinence (UI) prevalence reaches the 80% rate in female athletes involved in high-impact sports. In this context, although conservative treatment represents the first therapeutic choice, there is still a lack of knowledge on the efficacy of conservative programs in young female athletes. Therefore, the aim of this study was to investigate the role of pelvic floor rehabilitation in the treatment of UI in young nulliparous female athletes. We performed a literature search using PubMed, Medline, Cochrane Library, Web of Science, and Scopus. The selection of articles was conducted using a specific search string: “[((pelvic floor dysfunction) OR (urinary incontinence) OR (dyspareunia) OR (dysuria)) AND ((sport) OR (sports)) AND ((female) OR (woman) OR (women) OR (girl)) AND ((rehabilitation) OR (rehab) OR (pelvic rehabilitation) OR (exercise))]”. The review protocol was registered in PROSPERO with the ID CRD42024559990. A total of 1018 articles were found in all searches of the databases. After removing duplicates, 663 papers were reviewed in terms of title and abstract. Finally, a total of six studies were included in the present review. The results of this review show that conservative treatment with a personalised pelvic floor muscle training program (PFMTP) represents an effective treatment for UI, decreasing urine loss and improving maximum voluntary pelvic contraction; this is linked with an improvement in quality of life and sports performance, in particular when supervised by a physical therapist. Moreover, due to the reluctance of athletes to talk about UI, an educational program should be considered as part of a prevention programme in pre-season training.
Improving Cognitive and Chemosensory Function in Caenorhabditis elegans Through Polyphenol-Rich Sugarcane Extract
Authors: Heydarian Deniz , Flavel Matthew , Munasinghe Mihiri , Jois Markandeya , Thomas Jency
Published: December 2024

Polyphenols are recognized for their potential benefits in enhancing lifespan and stress resistance. This study investigates the impact of Polyphenol-Rich Sugarcane Extract (PRSE) from Saccharum officinarum on the chemosensory behavior, learning, and memory in Caenorhabditis elegans (C. elegans). The C. elegans worms were administered PRSE at 5 mg/mL from the first larval stage. Chemotaxis assays, positive butanone learning, and short-term associative memory assays were conducted at days four, eight, and twelve to evaluate chemosensory response, learning index, and short-term memory loss index. PRSE significantly improved the naïve chemotaxis index by 28.8% on day four, 30% on day eight, and 35.3% on day twelve compared to controls. The learning index increased by 14.5% on day four, 21% on day eight, and 31.9% on day twelve. Additionally, PRSE reduced the short-term memory loss index by 46.4% one hour after conditioning on day four and by 48.6% two hours after conditioning on day four, with similar reductions observed on days eight and twelve. These findings indicate that PRSE has the potential to enhance chemosensory behavior, learning, and memory in C. elegans, suggesting the need for further research to explore its applicability in addressing age-related chemosensory and cognitive decline.
Evaluation of the Effects of Drought Stress and Nitrogen-Sulfur Fertilization on Productivity and Yield Parameters of Spring Wheat
Authors: Juhász Evelin Kármen , Kremper Rita , Tállai Magdolna , Béni Áron , Novák Tibor , Balla Kovács Andrea
Published: December 2024

The combined effects of increasing sulfur (S) fertilization rates and drought stress on the yield and compositional parameters of spring wheat on Chernozem soil were studied. In a greenhouse pot experiment, increasing S doses (22.4, 28, 56 kg S/ha) were used with a constant nitrogen (N) dose (112 kg N/ha), resulting in different N:S ratios (1:0.2; 1:0.25; 1:0.5). Water supply treatments included optimal irrigation, maintaining 60% of field capacity, and a water stress treatment where irrigation was withheld until wilting symptoms appeared, followed by irrigation to 40% of field capacity. By measuring the dry biomass production; plant N and S%; and inorganic sulfate-S content, the N/S ratio; harvest index (HI); and organic S, N and S uptake were determined. Our findings indicate that, under water stress, S incorporation into plants is limited, as it tends to remain in an inorganic form. Furthermore, results showed an increase in the N/S ratio under drought conditions, suggesting that drought stress impedes S uptake more significantly than N uptake. In this experiment, fertilization with 112 kg N/ha and 56 kg S/ha (N:S = 1:0.5) proved to be most effective under adequate water supply. In this treatment, grain N and S% were 1.80% and 0.18%, respectively.
Automated Distal Radius and Ulna Skeletal Maturity Grading from Hand Radiographs with an Attention Multi-Task Learning Method
Authors: Liu Xiaowei , Wang Rulan , Jiang Wenting , Lu Zhaohua , Chen Ningning , Wang Hongfei
Published: December 2024

Background: Assessment of skeletal maturity is a common clinical practice to investigate adolescent growth and endocrine disorders. The distal radius and ulna (DRU) maturity classification is a practical and easy-to-use scheme that was designed for adolescent idiopathic scoliosis clinical management and presents high sensitivity in predicting the growth peak and cessation among adolescents. However, time-consuming and error-prone manual assessment limits DRU in clinical application. Methods: In this study, we propose a multi-task learning framework with an attention mechanism for the joint segmentation and classification of the distal radius and ulna in hand X-ray images. The proposed framework consists of two sub-networks: an encoder–decoder structure with attention gates for segmentation and a slight convolutional network for classification. Results: With a transfer learning strategy, the proposed framework improved DRU segmentation and classification over the single task learning counterparts and previously reported methods, achieving an accuracy of 94.3% and 90.8% for radius and ulna maturity grading. Findings: Our automatic DRU assessment platform covers the whole process of growth acceleration and cessation during puberty. Upon incorporation into advanced scoliosis progression prognostic tools, clinical decision making will be potentially improved in the conservative and operative management of scoliosis patients.
What Impacts Tourists’ Co-Creation Experiences in Smart Tourism Destinations? A Mixed Methods Research from Four Chinese Smart Tourism Destinations
Authors: Yin Yue , Gao Junjie , Pan Younghwan
Published: December 2024

In smart tourism, co-creation involves a collaborative effort among tourists, tourism service providers, and other stakeholders to enhance tourism experiences. This study aims to examine the factors influencing tourists’ co-creation experiences in smart tourism destinations through exploratory sequential mixed methods research. Participants who visited four Chinese smart tourism destinations took part in two study phases. In the first phase, eleven individuals identified the following five dimensions that might affect tourists’ co-creation experiences: smart environment; interactive activity; personalized service; cognitive engagement; and social interaction. In the second phase, an online survey was conducted with 283 respondents to validate these five dimensions. A structured equation model was utilized to analyze the collected data. The results indicated that all five dimensions identified in the qualitative study significantly influence tourists’ co-creation experiences. These findings offer theoretical and practical insights for future research on tourists’ co-creation experiences in smart tourism.
Correlates of Trachoma Recrudescence: Results from 51 District-Level Trachoma Surveillance Surveys in Amhara, Ethiopia
Authors: Sata Eshetu , Presley Nicholas A. , Le Phong , Nute Andrew W. , Ayele Zebene , Shiferaw Ayalew , Gessese Demelash , Chernet Ambahun , Melak Berhanu , Gonzalez Tania A. , Jensen Kimberly A. , Dawed Adisu Abebe , Zeru Taye , Tadesse Zerihun , Callahan Elizabeth Kelly , Nash Scott D.
Published: December 2024

Trachoma recrudescence is a serious concern for trachoma control programs. Programs define recrudescence as the return of trachomatous inflammation-follicular (TF) prevalence above elimination threshold (≥5%) on district-level trachoma surveillance surveys (TSSs). This study aimed to determine potential correlates of trachoma recrudescence within a historically highly endemic region. Between 2015 and 2021, population-based TSSs were conducted in 51 districts of Amhara, Ethiopia. District estimates were calculated accounting for multistage design; logistic regression was used to estimate the association of key correlates with recrudescence at the district level. Among the 51 districts, 17 (33%) were recrudescent. Correlates of recrudescence included indicators of historic trachoma burden, such as higher trachomatous inflammation-intense (TI) prevalence (odds ratio [OR]: 2.6, CI: 1.4–5.3) and higher Chlamydia trachomatis (Ct) infection prevalence (OR: 2.9, CI: 1.1–9.9) at the first recorded impact survey. The increased prevalence of children with clean faces (OR: 0.4, CI: 0.21–1.0) and the increased prevalence of travel time to a water source ≤ 30 min (OR: 0.5, CI: 0.2–1.1) at the TSS were associated with a protective effect from recrudescence. Data on historical trachoma burden as well as current water and sanitation conditions may help programs predict where recrudescence is more likely to occur and thus help programs sustain elimination as a public health problem.
From Paper to Digital: Performance and Challenges of the Electronic Hepatitis B Surveillance System in Ninh Binh, Northern Vietnam (2017–2022)
Authors: Nguyen Hien T. , Pham Thai Q. , Hoang Duc M. , Tran Quang D. , Chu Giang T. , Nguyen Thuong T. , Le Nam H. , Nguyen Huyen T. , Nguyen Khanh C. , Vogt Florian
Published: December 2024

Hepatitis B remains a major public health issue in Vietnam. Mandatory reporting to the national electronic communicable disease surveillance system (eCDS) has been required since July 2016. We conducted an evaluation of the hepatitis B surveillance system in Ninh Binh, the province with the highest reported burden of hepatitis B in Northern Vietnam, between 2017 and 2022. Using the CDC’s guidelines for evaluating public health surveillance systems, we assessed four key attributes: simplicity, timeliness, data quality, and acceptability. This retrospective evaluation included document reviews, analysis of hepatitis B data, and in-depth interviews with provincial-level healthcare staff involved in the reporting of hepatitis B cases. The results showed that the eCDS improved reporting frequency, provided more detailed case information, and enhanced data accessibility compared to the previous paper-based system. However, the system faced several challenges, including unclear objectives, difficulties in distinguishing acute from chronic cases, insufficient training for staff, lack of supervision for data quality, and technical software issues. Despite these challenges, stakeholders found the system acceptable but emphasized the need for improvements, including revising the system’s objectives, automating case classification, enhancing training, securing funding for maintenance, and implementing regular data review processes.
Urban Identity in Transition: A Metropolitan Analysis of Damascus
Authors: Mansour Hasan Mahmoud , Alves Fernando Brandão , Ricardo da Costa António
Published: December 2024

Facing substantial challenges due to rapid urbanization and socio-political shifts, the urban identities of our cities are in a state of significant transformation. This study explored the dynamic evolution of Damascus’s urban identity over distinct historical periods, employing a multi-dimensional methodology, which integrated spatial assessments, observational data from urban planners, and historical analyses. The findings revealed a transition from a stable urban identity in the pre-colonial period, to fragmented and, eventually, lost states in the post-colonial era. This study has underscored the need for strategic interventions to preserve the city’s identity amidst modernization pressures, providing valuable insights for urban planners and policymakers. The findings underscore the pressing need for strategic, context-sensitive interventions that can restore and revitalize Damascus’s unique urban identity, contributing to a broader discourse on the sustainable preservation of the cultural heritage in historic cities facing modernization pressures.
Depreciation in the Electric Vehicle Transition: Sustainability of the Second-Hand Electric Vehicle Market
Authors: Gautam Patil , Pode Gayatri , Pode Ramchandra , Ayetor Godwin Kafui , Diouf Boucar
Published: December 2024

Electric vehicles (EVs) are revolutionizing road transport. They represented the most reliable and realistic option to decarbonize road transport in the last 10 years and look to be holding a promising future. EVs are in competition with internal combustion engine (ICE) vehicles, but they still have a lower performance, particularly in range, and they remain more expensive. To guarantee the EV development and make it a sustainable substitution to ICE vehicles, the EV industry and technology development had been mostly supported by governments’ subsidies. One of the main issues EVs are facing is that they depreciate much faster than ICE vehicles, principally due to rapid technological progress that drives the market on the one hand and, on the other, makes older EV models prematurely obsolete. The other variable that contributes to faster EV depreciation is subsidies. It is expected that the end of subsidies will bring the necessary leverage to slow down EVs fast depreciation due to the wider price gap between new and pre-owned EVs. Batteries, which make EVs a practical reality, play a major role in EV depreciation. Besides the possible degradation of EV batteries, the technology development and price drop give newer models better range at a lower cost. The second-hand EV market is a fair reflection of the fast depreciation of EVs; naturally, the two subjects should be studied correlatively. It may not be obvious to draw an obvious correlation, but it seems clear that the fast depreciation of EVs is one of the major reasons why the second-hand EV market is still minor. Depreciation is a major driver of the second-hand EV market. In this manuscript are presented the main aspects of EV depreciation, particularly those related to fast technological evolution, including batteries and subsidies, as well as the second-hand EV market.
Integration of Frequency-Selective Surfaces as Smart Skins in Building Envelopes and Divisions: Insulation and Energy Issues
Authors: Cuiñas Iñigo , Expósito Isabel , Andriukaitis Darius , Caldeirinha Rafael F. S. , García Sánchez Manuel , Valinevičius Algimantas
Published: December 2024

Frequency-Selective Surfaces (FSSs) are structures that act as frequency-dependent electromagnetic filters, enabling innovative designs for energy-efficient building envelopes. This paper explores their potential for energy harvesting and integration into construction materials, offering insights into design strategies, performance analysis, and potential applications of FSS sin future architectural projects. A range of FSS designs are presented and systematically classified based on their performance and adaptability for building integration. This includes their use as part of traditional construction elements or as independent components of building walls. Critical issues such as the limitations, challenges, and durability of FSSs in real-world applications are also examined to provide a comprehensive view of their practical feasibility. Additionally, incorporating the electromagnetic properties of these materials into Building Information Modelling (BIM) systems is recommended. Doing so will enable architects and engineers to better utilize the novel opportunities that FSSs offer, fostering more innovative, energy-efficient building envelopes. Overall, this paper provides valuable insights into how FSSs can transform the future of sustainable architecture and energy management in buildings.
Promoting Healthy Lifestyles: Availability of Healthy Resources and Prescriptions from Health Professionals—The Case of Tarragona, Spain
Authors: Bustamante-Picón Edgar , Cuesta-Martínez Roser , Pérez-Albert Yolanda , Alberich González Joan , Raventós Torner Rosa D.
Published: December 2024

This research provides a comprehensive view of the geolocation of physical health assets in the city of Tarragona (Spain) and how these assets are used and recommended by healthcare professionals to promote healthy lifestyles. Focusing on the distribution and accessibility of sports facilities, such as outdoor gyms or football and basketball courts, this study highlights the importance of these assets in leading a healthy life and preventing chronic diseases. This article investigates the availability of these assets and their prescription by healthcare professionals to improve people’s quality of life through surveys and fieldwork. It evaluates both the knowledge healthcare professionals have about these available assets in the area and the types of physical activity they prescribe. The results show significant variability in the availability of physical health assets across different neighbourhoods. However, most residents have good walking access to these assets, especially in the central and western parts of the city. This study concludes that while physical health assets are an underutilised resource for healthcare professionals, enhancing the awareness and prescription of these assets could improve public health outcomes, particularly for older adults.
A systematic review of recent research and novel methods in diagnosis and treatment of bipolar affective disorder
Authors:   Federal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Health of the Russian Federation, Rostov-on-Don, Russia, Bodenko E. E. , Darsigova S. A. ,   Federal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Health of the Russian Federation, Rostov-on-Don, Russia, Tkachenko N. V. ,   Federal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Health of the Russian Federation, Rostov-on-Don, Russia
Published: December 2024

This article reviews information on the application and research of new technologies in the diagnosis
and treatment of bipolar affective disorder. This disease is a rather severe pathology of the psyche, characterized by periodic episodes of mania or hypomania and episodes of depression that succeed each other, which has a detrimental effect on the quality of life of individuals affected by the aforementioned disease. However, new technologies such as deep brain stimulation, artificial intelligence, telemedicine, and genetic research to identify markers of bipolar disorder, which contribute to scientific progress in solving this problem, together with psychotherapy, are a crucial link that complements treatment, allowing taking it to a new level. Certainly, the relevance and effectiveness of a particular method of treatment and diagnosis is confirmed by numerous studies. For instance, the evidence of the effectiveness of deep brain stimulation is still at the research stage, while telemedicine is actively used in treatment, but is not yet officially included in the standards of clinical recommendations. Also, according to the scientific literature, blood markers have a fairly high effect in diagnosis, but are not officially indicated for use among routine examinations worldwide. The application of artificial intelligence at the present time is only possible under the control of a human specialist, therefore this method, like deep brain stimulation, is at the development stage. Meanwhile, various apps (e.g., Moodpath) are actively used, despite the fact that the evidence base for their efficacy is still at the stage of collecting evidence and conducting research.
NUTRITION EDUCATION MEDIA FOR DIABETES MELLITUS PATIENTS: VIDEO OF DAFTAR BAHAN MAKANAN PENUKAR (DBMP)
Authors: Nuswantari Atika , Dewi Yulia Lanti Retno , Rahardjo Setyo Sri
Published: December 2024

Prevalensi penderita diabetes melitus (DM) di Jawa Timur menurut Survei Kesehatan Indonesia tahun 2023 meningkat (0,1%) dari sebelumnya tahun 2018, yakni 2,7%. Penelitian ini bertujuan untuk mengembangkan media daftar bahan makanan penukar sebagai media edukasi  diet DM pada penderita DM. Penelitian ini menggunakan metode Research and Development (R&D) dengan model Analyze, Design, Development, Implementation, Evaluation (ADDIE) untuk mengembangkan media edukasi dan pada tahap implementation dilakukan dengan metode quasy experimental dengan rancangan pre post-test with a control group. Penelitian ini melibatkan partisipasi tiga validator ahli dan 10 penderita DM sebagai calon pengguna. Pengumpulan data melalui wawancara dan kuesioner penilaian media. Jumlah subjek pada tahap implementation terdiri atas 40 penderita DM. Analisis data menggunakan teknik deskriptif. Hasil penilaian kelayakan media oleh ahli diperoleh skor rata-rata 91.03% dengan kategori sangat layak dan uji coba media pada kelompok calon pengguna diperoleh skor rata-rata 92.5% dengan kategori sangat layak. Video DBMP dapat digunakan sebagai media edukasi gizi diet DM pada penderita DM. Uji beda skor pengetahuan diet DM menggunakan analisis statistik Paired Sample T-Test. Dari hasil penelitian diperoleh nilai p=0.031 pada kelompok intervensi di tahap evaluation dan nilai p=0,648 pada kelompok kontrol. Hal ini menunjukkan bahwa terdapat perbedaan skor pengetahuan yang signifikan pada kelompok intervensi setelah 3 kali pemberian konseling gizi diet DM. Tahap akhir evaluasi dianalisis menggunakan post hoc Mann Whitney u test, menunjukkan bahwa ada perbedaan yang signifikan (p=<0.001) antara kelompok kontrol dan kelompok intervensi (video DBMP).
Involvement of Mineralocorticoid Receptor Activation by High Mobility Group Box 1 and Receptor for Advanced Glycation End Products in the Development of Acute Kidney Injury
Authors: Otsuka Tomoyuki , Ueda Seiji , Yamagishi Sho-ichi , Nagasawa Hajime , Okuma Teruyuki , Wakabayashi Keiichi , Kobayashi Takashi , Murakoshi Maki , Nakata Masami , Gohda Tomohito , Matsui Takanori , Higashimoto Yuichiro , Suzuki Yusuke
Published: December 2024

Key Points

Our study revealed that high mobility group box 1 activates the mineralocorticoid receptor (MR) through the receptor for advanced glycation end products (RAGE) in AKI.

MR antagonists and RAGE aptamers inhibited high mobility group box 1–induced Rac1/MR activation and downstream inflammatory molecules in endothelial cells.

MR antagonists and RAGE aptamers may represent promising therapeutic strategies for preventing AKI and CKD progression.

Background

Although AKI is associated with an increased risk of CKD, the underlying mechanisms remain unclear. High mobility group box 1 (HMGB1), one of the ligands for the receptor for advanced glycation end products (RAGE), is elevated in patients with AKI. We recently demonstrated that the mineralocorticoid receptor (MR) is activated by the RAGE/Rac1 pathway, contributing to chronic renal damage in hypertensive mice. Therefore, this study investigated the role of the HMGB1/RAGE/MR pathway in AKI and progression to CKD.

Methods

We performed a mouse model of renal ischemia–reperfusion (I/R) with or without MR antagonist (MRA). In vitro experiments were conducted using cultured endothelial cells to examine the interaction between the HMGB1/RAGE and Rac1/MR pathways.

Results

In renal I/R injury mice, renal MR activation was associated with elevated serum HMGB1, renal RAGE, and activated Rac1, all of which were suppressed by MRA. Renal I/R injury led to renal dysfunction, tubulointerstitial injury, and increased expressions of inflammation and fibrosis mediators, which were ameliorated by MRA. In vitro, RAGE aptamer or MRA inhibited HMGB1-induced Rac1/MR activation and upregulation of monocyte chemoattractant protein 1 and NF-κB expressions. Seven days after I/R injury, renal I/R injury mice developed CKD, whereas MRA prevented renal injury progression and decreased the mortality rate. Furthermore, in case of MRA treatment even after I/R injury, attenuated renal dysfunction compared with untreated mice was also observed.

Conclusions

Our findings suggest that HMGB1 may play a crucial role in AKI and CKD development by activating the Rac1/MR pathway through interactions with RAGE.