bluuebunny/crossref_metadata_2025 huggingface dataset:
Nitrogen Application Rate Affects the Accumulation of Carbohydrates in Functional Leaves and Grains to Improve Grain Filling and Reduce the Occurrence of Chalkiness
Authors: Guo Changchun , Yuan Xiaojuan , Yan Fengjun , Xiang Kaihong , Wu Yunxia , Zhang Qiao , Wang Zhonglin , He Limei , Fan Ping , Yang Zhiyuan , Chen Zongkui , Sun Yongjian , Ma Jun
Published: June 2022

Chalkiness, which is highly affected by nitrogen (N) management during grain filling, is critical in determining rice appearance quality and consumer acceptability. We investigated the effects of N application rates 75 (N1), 150 (N2), and 225 (N3) kg ha−1 on the source-sink carbohydrate accumulation and grain filling characteristics of two indica hybrid rice cultivars with different chalkiness levels in 2019 and 2020. We further explored the relationship between grain filling and formation of chalkiness in superior and inferior grains. In this study, carbohydrates in the functional leaves and grains of the two varieties, and grain filling parameters, could explain 66.2%, 68.0%, 88.7%, and 91.6% of the total variation of total chalky grain rate and whole chalkiness degree, respectively. They were primarily concentrated in the inferior grains. As the N fertilizer application rate increased, the chalky grain rate and chalkiness degree of both the superior and inferior grains decreased significantly. This interfered with the increase in total chalky grain rate and chalkiness. Moreover, the carbohydrate content in the functional leaves increased significantly in N2 and N3 compared with that in N1. The transfer of soluble sugar from the leaves to the grains decreased the soluble sugar and increased total starch contents, accelerated the development of grain length and width, increased grain water content, and effectively alleviated the contradiction between source and sink. These changes promoted the carbohydrate partition in superior and inferior grains, improved their average filling rate in the middle and later stages, optimized the uniformity of inferior grain fillings, and finally led to the overall reduction in rice chalkiness.
Effects of Nitrogen Addition on Soil Carbon-Fixing Microbial Diversity on Different Slopes in a Degraded Alpine Meadow
Authors: Li Chengyi , Li Xilai , Shi Yan , Yang Yuanwu , Li Honglin
Published: June 2022

Autotrophic carbon-fixing bacteria are a major driver of carbon sequestration and elemental cycling in grassland ecosystems. The characteristics of the response of carbon-fixing bacterial communities to nitrogen (N) addition in degraded alpine meadows are unclear. In this study, it was investigated that the effects of N addition in three levels [they are low (LN), middle (MN), and high (HN) with N supplement of 2, 5, and 10 g N⋅m–2⋅a–1, respectively] on soil carbon-fixing bacteria on different slopes in a degraded alpine meadow in the Yellow River on the Qinghai–Tibet Plateau. The results showed that there were significant differences in the abundance of some low abundance genera of carbon-fixing bacteria on the same slope (P < 0.05), but the differences in the abundance of various phyla and dominant genera were not significant. MN on gentle slopes significantly reduced the Chao1 index and observed species (P < 0.05), whereas N addition on steep slopes had no significant effect on the diversity. The abundance of the Cyanobacteria phylum and 28 genera of identified carbon-fixing bacteria differed significantly between slopes (P < 0.05), and observed species of carbon-fixing bacteria were significantly higher on steep slopes than on gentle slopes (P < 0.05). Factors affecting the carbon-fixing bacteria community structure include slope, N addition, ammoniacal nitrogen (N-NH4+), microbial biomass carbon (MBC), soil water content (SWC), pH, soil C:N ratio, and microbial C:N ratio. Slope, N addition, soil physicochemical properties, microbial biomass, and stoichiometric ratio did not significantly affect the carbon-fixing bacteria diversity. Thus, the effect of exogenous N addition on carbon-fixing bacteria in degraded alpine meadows was dependent on slope conditions, and the response of carbon-fixing bacteria abundance and species number to N addition on gently slope sites was threshold-limited.
RETRACTED: Effects of “Mindfulness Acceptance Insight Commitment” Training on Flow State and Mental Health of College Swimmers: A Randomized Controlled Experimental Study
Authors: Ning Jun-hui , Hao Qing-wei , Huang Da-cai
Published: June 2022

This research explores the intervention effect of the mindfulness acceptance insight commitment (MAIC) training program on the mindfulness level, flow state, and mental health of college swimmers. A sample of 47 college swimmers from a regular university was recruited and randomly divided into two groups before the intervention. Independent variables between groups are psychological training mode (MAIC training/no training), and the independent variable within group was time (pre-test, post-test, and continuity test). The dependent variables are mindfulness level, flow state, and mental health (anxiety, depression, training, and competition satisfaction). Results show that after the intervention of MAIC training, the mindfulness level of athletes’ flow state has been significantly improved, whereas anxiety and depression significantly decreased. In addition, the satisfaction with training and competition significantly improved. In the continuous stage after the intervention, the mindfulness level, flow state, and mental health of athletes are still significantly higher than those in the pre-test. The comparison of the post-test and continuity test show no significant differences in the mindfulness level, flow state, depression, and training and competition satisfaction of athletes. Still, the anxiety level shows an upward trend with a significant difference. This study demonstrates that the MAIC mindfulness training program can significantly improve the mindfulness level, flow state, anxiety, depression, and training and competition satisfaction of college swimmers with a good continuity effect. Thus, the athletes’ sports experience can be improved, and good psychological benefits can be attained.
Cultivation of Entrepreneurial Psychological Quality and Optimization of Piano Talents Training in Colleges and Universities Through Questionnaire Survey
Authors: Gao Yinai
Published: June 2022

The mechanism is studied to optimize the cultivation of piano talents and entrepreneurial psychological quality (PSYQ) in colleges and universities through the QS (Questionnaire Survey). Firstly, the cultivation of piano talents’ entrepreneurial consciousness is explored, together with the entrepreneurial will, entrepreneurial personality, and entrepreneurial ability. Secondly, the piano talents entrepreneurial PSYQ training model is established according to the internal factors of college students majoring in piano, entrepreneurial attitude, students’ interpersonal network, and entrepreneurial environment factors. The correlations between various variables are analyzed. Afterward, a QS is designed, and the data are collected from university A in the city of Xi’an. Data analysis shows significant differences in the cultivation of entrepreneurial PSYQ among students of different grades in college Piano Majors, namely, p < 0.01. Students growing up in different environments show significant differences in entrepreneurial PSYQ, namely, p < 0.01. Meanwhile, whether students have served as cadres will also have a particular impact on students’ entrepreneurial PSYQ, namely, p < 0.01. However, the dimension of only-child-or-not in entrepreneurial PSYQ training does not show a significant difference. Finally, under the model analysis, achievement motivation, entrepreneurial attitude, entrepreneurial interest, entrepreneurial consciousness, interpersonal network, entrepreneurial environment, and personal entrepreneurial background will affect the cultivation of their entrepreneurial PSYQ. They show a positive correlation with the entrepreneurial PSYQ. Therefore, in the future college piano talents training and entrepreneurial PSYQ training, more focus should be put on students’ innovative thinking and risk challenging capacity, thereby helping students with better entrepreneurial work.
Analysis of Learning Behavior of Human Posture Recognition in Maker Education
Authors: Huang Yueh-Min , Cheng An-Yen , Wu Ting-Ting
Published: June 2022

Maker education mainly involves “hands-on” as the core concept and combines various educational theories to redefine interactions between learners and teachers in a learning environment. Identification of meaningful “hands-on” behaviors is crucial to evaluate students’ learning performance, although an instructor’s observation of every student is not feasible. However, such observation is possible with the aid of the artificial intelligence (AI) image processing technique; the AI learning behavior recognition system can serve as the second eyes of teachers, thus accounting for individual differences. However, in previous studies, learning behavior recognition was applied to the traditional or static classroom. A behavior recognition system for identifying “hands-on” actions in the learning context has still not been developed. Therefore, this study designed a human posture evaluation system, obtained human articulation node information from learning field images, and built a learning behavior recognition model suitable for maker education based on the AI convolutional neural network (CNN). A learning behavior model was defined, along with a number of student behavior indexes. Subsequently, the effectiveness of the model and behavior indexes was verified through practical learning activities. The model evaluation results indicated that the proposed model achieved a training accuracy of 0.99 and a model accuracy of 0.83. Thus, the model can be applied to dynamic maker activity learning environments.
Exploring Factors of the Willingness to Accept AI-Assisted Learning Environments: An Empirical Investigation Based on the UTAUT Model and Perceived Risk Theory
Authors: Wu Wentao , Zhang Ben , Li Shuting , Liu Hehai
Published: June 2022

Artificial intelligence (AI) technology has been widely applied in many fields. AI-assisted learning environments have been implemented in classrooms to facilitate the innovation of pedagogical models. However, college students' willingness to accept (WTA) AI-assisted learning environments has been ignored. Exploring the factors that influence college students' willingness to use AI can promote AI technology application in higher education. Based on the Unified Theory of Acceptance and Use of Technology (UTAUT) and the theory of perceived risk, this study identified six factors that influence students' willingness to use AI to analyze their relationships with WTA AI-assisted learning environments. A model including six hypotheses was constructed to test the factors affecting students' WTA. The results indicated that college students showed “weak rejection” of the construction of AI-assisted learning environments. Effort expectancy (EE), performance expectancy (PE), and social influence (SI) were all positively related to college students' WTA AI-assisted learning environments. Psychological risk (PR) significantly negatively influenced students' WTA. The findings of this study will be helpful for carrying out risk communication, which can promote the construction of AI-assisted learning environments.
Developmental Dyslexia: Disorder or Specialization in Exploration?
Authors: Taylor Helen , Vestergaard Martin David
Published: June 2022

We raise the new possibility that people diagnosed with developmental dyslexia (DD) are specialized in explorative cognitive search, and rather than having a neurocognitive disorder, play an essential role in human adaptation. Most DD research has studied educational difficulties, with theories framing differences in neurocognitive processes as deficits. However, people with DD are also often proposed to have certain strengths – particularly in realms like discovery, invention, and creativity – that deficit-centered theories cannot explain. We investigate whether these strengths reflect an underlying explorative specialization. We re-examine experimental studies in psychology and neuroscience using the framework ofcognitive search, whereby many psychological processes involve a trade-off between exploration and exploitation. We report evidence of an explorative bias in DD-associated cognitive strategies. High DD prevalence and an attendant explorative bias across multiple areas of cognition suggest the existence of explorative specialization. An evolutionary perspective explains the combination of findings and challenges the view that individuals with DD have a disorder. In cooperating groups, individual specialization is favored when features that confer fitness benefits are functionally incompatible. Evidence for search specialization suggests that, as with some other social organisms, humans mediate the exploration–exploitation trade-off by specializing in complementary strategies. The existence of a system of collective cognitive search that emerges through collaboration would help to explain our species’ exceptional adaptiveness. It also aligns with evidence for substantial variability during our evolutionary history and the notion that humans are adapted not to a particular habitat but to variability itself. Specialization creates interdependence and necessitates balancing complementary strategies. Reframing DD therefore underscores the urgency of changing certain cultural practices to ensure we do not inhibit adaptation. Key improvements would remove cultural barriers to exploration and nurture explorative learning in education, academia, and the workplace, as well as emphasize collaboration over competition. Specialization in complementary search abilities represents a meta-adaptation; through collaboration, this likely enables human groups (as a species and as cultural systems) to successfully adapt. Cultural change to support this system of collaborative search may therefore be essential in confronting the challenges humanity now faces.
Board Gender Diversity, Corporate Social Responsibility Disclosure, and Firm’s Green Innovation Performance: Evidence From China
Authors: Naveed Khwaja , Voinea Cosmina L. , Roijakkers Nadine
Published: June 2022

The current research investigates the interplay of board gender diversity (BGD), the quality of corporate social responsibility disclosure (CSRD), and the green innovation performance (GIP) of a firm. It examines the moderation effect of the CSRD on the relationship between corporate GIP and BGD. The study inculcates 3,736 firm-year observations of A-share listed Chinese firms from 2010 to 2019. Least square dummy variables method, generalized method of moments, and 2SLS are employed for the analysis of the study. The findings foster an affirmative and significant impact of BGD on corporate GIP in terms of green innovation patents. Moreover, the quality of CSRD is also detected for a significant moderating effect on the relationship between BGD and corporate GIP. The quality of CSRD emerges to be an indicator for social resilience and female role congruence under the purview of the social resilience theory and the role congruence theory, respectively. This research would help managers and policymakers of developing nations in formulating environmental innovation strategies for corporate sustainability.
Assessing the Antecedents and Consequences of Experience Value in Online Education: A Quantitative Approach
Authors: Zhao Hong , Song Lijuan
Published: June 2022

The experience value of online education is a hot topic in both theoretical and practical circles, but research on its mechanism of action is limited. Therefore, this study systematically investigates the relationship between brand image, experience value, and continuance intention through a theoretical analysis of brand image, and discusses the boundary role of effective commitment in it. In this study, 475 users were used to conduct structural equation modeling analysis. The results of the study found that experience value had a positive and significant effect on user continuance intention under the significant influence of brand image, but affective commitment did not play a positive moderating role in the relationship between experience value and continuance intention. This study examines the mechanism of the antecedents and consequences of experience value, and provides a new direction for the construction of online education and the development of online education and marketing strategies.
Inhibitory Control of Emotional Interference in Deaf Children: Evidence From Event-Related Potentials and Event-Related Spectral Perturbation Analysis
Authors: Chen Qiong , Zhao Junfeng , Gu Huang , Li Xiaoming
Published: June 2022

Background

Impairment of interference control ability may reflect a more general deficit in executive functioning, and lead to an increase in internal-externalized problems such as impulsivity, which has been reported in deaf children. However, few researches have examined the neural mechanism of this impairment.

Methods

This study applied the electroencephalogram (EEG) technique to investigate the interference control ability in 31 deaf children and 28 hearing controls with emotional face-word stroop task.

Results

Results from behavioral task showed that deaf children exhibited lower accuracy compared to hearing controls. As for EEG analysis, reduced activation of ERP components in N1 and enhanced activation of ERP components in N450 have been found in deaf children. Besides, incongruent condition elicited larger N450 than congruent condition. Furthermore, for brain oscillation, alpha band (600–800 ms) revealed a reduced desynchronization in deaf children, while theta band (200–400 ms) revealed an enhanced synchronization in deaf children and incongruent condition, which were in line with ERP components.

Conclusion

The present findings seem to indicate that the deficit during emotional interference control ability among deaf children might be due to the impaired attention allocation ability and emotional cognitive monitoring function during emotional conflict detection process. Consequently, reduced N1 and enhanced N450 might be due to early attention impairment causing more effort of deaf children later in emotional cognitive monitoring.
Text Messages in the Field of Mental Health: Rapid Review of the Reviews
Authors: Shalaby Reham , Adu Medard K. , El Gindi Hany M. , Agyapong Vincent I. O.
Published: June 2022

Background

While mental health problems constitute a worldwide concern contributing to the global rates of morbidity and mortality, conventional mental healthcare services do not meet the current needs. Text messages (TM) represent a live model that incorporates technology into health services, spanning a large number of health conditions and playing different roles that may support the current healthcare system.

Objective

To examine the TM services in the field of mental health, regarding their effectiveness, feasibility, acceptability, and economic evaluation in different contexts of mental health diagnoses and during critical times, when provided to individuals with mental health symptoms/disorders.

Methods

This rapid review was conducted through an online search in PubMed, Embase, PsycINFO, and Medline databases. The review targeted the review studies which examined online or mobile addiction and mental health services, utilizing TM services. The search was run from the inception up to September 30, 2021.

Results

Sixty review articles met the inclusion criteria and were included in this review. All reviews were published over the last decade. The results showed that people of a young age were fairly represented, and most reviews were run over substance use disorders (SUD), including Alcohol. Most reviews examined the effectiveness outcomes of the texting service, while to a lesser extent the acceptability and feasibility, among others. Texting services were reported as effective in psychotic disorders and SUD. However, the results related to depression and anxiety were mixed. Most reviews reported a considerably high risk of bias among their included studies. High satisfaction and acceptability of the texting services were reported for patients with various mental health conditions, including those with severe mental illness.

Conclusions

This rapid review highlighted the applications, usability, benefits, and satisfaction with the TM in the field of mental health. For a higher quality of evidence, future studies should consider TM interventions in the contexts with mixed results or a dearth of literature, and during critical times, such as the COVID-19 pandemic. Policy- and decision-makers, therefore, need to further support text-based services with guided investments in interventions that were evidenced to be accepted, economic and feasible.
Rethinking Accessibility in Light of the Orange Declaration: Applying a Socio-Ecological Lens to Rural Mental Health Commissioning
Authors: Coleman Mathew , Cuesta-Briand Beatriz , Collins Noel
Published: June 2022

The prevalence of mental illness is a critical public health issue. In Australia, the prevalence of mental illness is similar across all settings, however, people living in rural and remote areas experience worse outcomes than their urban counterparts. Access to mental health services is critical, however, the notion of accessibility needs to be understood in the context of the uniqueness and variability of the rural experience. The Orange Declaration on Rural and Remote Mental Health recognized that rural areas face a series of interconnected challenges and called for place-specific responses and new funding models that reward collaboration and local partnerships. In this paper, we argue that recent mental health planning, policy and service development uses a narrow interpretation of the notion of accessibility that is out of step with current thinking on the heterogeneity of the rural experience. We use some examples of our own research and experience in rural Western Australia to argue that the current commissioning model is not aligned with the Orange Declaration, and remains largely metro-centric and reliant on a narrow conceptualization of service accessibility. We argue that what is needed is a dynamic, responsive, context-sensitive understanding of accessibility that is informed by the distinctiveness of rural adversity, and recognizes the heterogeneity and variability of the rural experience whilst acknowledging rural agency and social capital, and we suggest that applying a socio-ecological approach to the development of new commissioning models provides a way forward.
The Analytical Framework of Governance in Health Policies in the Face of Health Emergencies: A Systematic Review
Authors: Díaz-Castro Lina , Ramírez-Rojas María Guadalupe , Cabello-Rangel Héctor , Sánchez-Osorio Ever , Velázquez-Posada Mauricio
Published: June 2022

The Governance Analytical Framework (MAG) defines governance as a social fact, endowed with analyzable and interpretable characteristics, through what it calls observable constitutive elements of governance: the problem, the actors, the social norms, the process of decision-making and scope or nodal points; in the sense that each society develops its modes of governance, its decision-making or conflict resolution systems among its members, its norms, and institutions. In this perspective, the purpose of this article was to carry out a systematic review of the scientific literature to understand the role of governance in health policies in health emergencies, such as that caused by the SARS-CoV-2. The systematic review was designed based on the methodology proposed in the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) Declaration. The literature search was carried out in six databases: Psychology and Behavioral Sciences, APA-PsycInfo, MEDLINE, eBook Collection (EBSCOhost), PubMED, and MedicLatina, published in the last 5 years. Fifteen articles that met quality and evidence criteria were analyzed. The governance approach alluding to the health emergency problem in health policies was the most addressed by the authors (80%), followed by a description of the actors (40%), the process of decision-making spaces (33%), and ultimately, social norms or rules with 13%. Formulating a coherent set of global health policies within a large-scale global governance framework is mostly absent. Although the countries adopt international approaches, it is a process differentiated by the social, economic, and political contexts between countries, affecting heterogeneous health outcomes over the pandemic.
Does Giving and Receiving Helping Behavior Fit Matter? The Role of Neighboring Behavior Fit in Working Residents' Mental Health
Authors: Xiu Jing , Zhang Zhenduo , Fan Youqing , Zheng Junwei
Published: June 2022

Ecological systems theory suggests that for individuals, the three domains of community, family, and work are connected and transfer resources among each other. In the community, residents receive and give helping behavior from and to their neighbors. Neighboring behavior underlies interactions among residents in the community, thereby influencing the work and family domains. Building on ecological systems theory, the authors propose that the compatibility of receiving and giving helping behavior among working residents is related to their mental health. Additionally, the authors propose that this congruence effect functions through work-family interference and meaning in life. Using a two-stage field questionnaire survey, this study collected data from 220 full-time Chinese working residents. Using polynomial regression and response surface analysis, receiving-giving neighboring behavior fit was found to be positively associated with mental health. Furthermore, receiving-giving neighboring behavior fit enhances mental health by decreasing work-family interference and promoting meaning in life. When giving and receiving neighboring behavior are imbalanced, working residents have higher levels of mental health when they received more neighboring behavior than they gave, in comparison to the condition when they gave more neighboring behavior than they received. Work-family interference represents inter-role conflict in which pressures from the family and work domains are mutually incompatible. Including both work to family interference and family to work interference, work-family interferences reflect the stress that working residents experience in their family and work domains. By exploring the mediating role of work-family interference, this study shows how the spillover of the benefits of neighboring behavior into the family and work domains enhances working residents' mental health. This study highlights the importance of balancing receiving and giving neighboring behavior for maintaining mental health, thus contributing both theoretically and practically to ecological systems theory.
Strategies For Enhancing Equity, Diversity, and Inclusion in Medical School Admissions–A Canadian Medical School's Journey
Authors: Joy Tisha R.
Published: June 2022

Background

Medical schools aim to select and train future physicians representative of and able to serve their diverse population needs. Enhancing equity, diversity, and inclusion (EDI) in admissions processes includes identifying and mitigating barriers for those underrepresented in medicine (URM).

Summary of Innovations

In 2017, Schulich School of Medicine and Dentistry (Western University, Ontario, Canada) critically reviewed its general Admissions pathways for the Doctor of Medicine (MD) program. Till that time, interview invitations were primarily based on academic metrics rather than a holistic review as for its Indigenous MD Admissions pathway. To help diversify the Canadian physician workforce, Schulich Medicine utilized a multipronged approach with five key changes implemented over 2 years into the general MD Admissions pathways: 1. A voluntary applicant diversity survey (race, socioeconomic status, and community size) to examine potential barriers within the Admissions process; 2. Diversification of the admissions committee and evaluator pool with the inclusion of an Equity Representative on the admissions committee; 3. A biosketch for applicants' life experiences; 4. Implicit bias awareness training for Committee members, file reviewers and interviewers; and 5. A specific pathway for applicants with financial, sociocultural, and medical barriers (termed ACCESS pathway). Diversity data before (Class of 2022) vs. after (Class of 2024) these initiatives and of the applicant pool vs. admitted class were examined.

Conclusion

For the Class of 2024, the percentage of admitted racialized students (55.2%), those with socioeconomic challenges (32.3%), and those from remote/rural/small town communities (18.6%) reflected applicant pool demographics (52.8, 29.9, and 17.2%, respectively). Additionally, 5.3% (vs. 5.6% applicant pool) of admitted students had applied through ACCESS. These data suggest that barriers within the admissions process for these URM populations were potentially mitigated by these initiatives. The initiatives broadly improved representation of racialized students, LGBTQ2S+, and those with disability with statistically significant increases in representation of those with socioeconomic challenges (32.3 vs. 19.3%, p = 0.04), and those with language diversity (42.1 vs. 35.0%, p = 0.04). Thus, these changes within the general MD admissions pathways will help diversify the future Canadian physician workforce and inform future initiatives to address health equity and social accountability within Canada.
Human Health, Environmental Quality and Governance Quality: Novel Findings and Implications From Human Health Perspective
Authors: Zhang Liqin , Yang Yuping , Lin Yesong , Chen Huangxin
Published: June 2022

Human health and wellbeing are intimately linked to the state of the environment. The current study emphasizes the role of environmental quality, government policies, and human health. This paper provides a detailed literature review of existing findings regarding our key variables of interest. The results argue that the implications of poor government policies and environmental pollution for rising economic development have led to poor environmental quality and health issues for humans. Based on earlier investigations, the present study reviewed the state-of-the-art review and determined innovative insights for outdoor and indoor environment difficulties. This study provides a detailed review of human health, environmental quality, and governance quality. In addition, the study conducts an empirical analysis using the annual data of low-income countries from 1996 to 2020. Government actions and health systems must be modified immediately to address these rising concerns successfully. The report offers policy recommendations for addressing health, governance, and environmental change mitigation issues, all of which are directly or indirectly related to the study. This article presents an overview of environmental change's health impacts and explores how health hazards may be reduced or eliminated through effective adaptation strategies.
Association of Habitual Physical Activity With the Risk of All-Cause Mortality Among Chinese Adults: A Prospective Cohort Study
Authors: Hu Peng , Zheng Murui , Huang Jun , Zhao Wenjing , Wang Harry H. X. , Zhang Xiong , Chen Yuanyuan , Deng Hai , Qin Pengzhe , Liu Xudong
Published: June 2022

Objective

This study was conducted to evaluate the association of the risk of all-cause mortality with habitual physical activity (HPA) and its different domains among Chinese adults.

Methods

A total of 11,994 participants from the Guangzhou Heart Study were followed up until 1 January 2020. Information on HPA, including leisure-time physical activity (LTPA) and commute activity, was collected using a modified Global Physical Activity Questionnaire. Individual cause of death was obtained from the National Death Registry of China. Cox proportional hazards regression model was used to estimate hazard ratio (HR) and 95% confidence interval (CI) after adjustment for covariates.

Results

During 37,715 person-years of follow-up, 208 deaths (1.73%) were observed. When compared with the highest with the lowest exposure tertiles, HPA and LTPA were associated with 34% (HR: 0.66, 95% CI: 0.46–0.95) and 30% (HR: 0.70, 95% CI: 0.49–0.99) reduced risk of all-cause mortality after adjustment for covariates. Commute activity was not associated with mortality risk. For the specific component of LTPA, we found that every 1 MET-h/week increment of the housework was associated with a 1% (HR: 0.99, 95% CI: 0.98–0.99) decreased mortality risk, and performing brisk walking/health exercises/Yangko was associated with a 46% reduced mortality risk (HR: 0.54, 95% CI: 0.29–0.99).

Conclusion

This study suggests that a higher level of HPA and LTPA was associated with a lower risk of all-cause mortality. Our findings suggest people to perform HPA, especially LTPA, as a strategy for mortality reduction and health promotion.
Utility and Feasibility of Transcutaneous Spinal Cord Stimulation for Patients With Incomplete SCI in Therapeutic Settings: A Review of Topic
Authors: Martin Rebecca
Published: June 2022

Transcutaneous Spinal Cord Stimulation (TSCS) has been shown to enhance the excitability of spinal neural circuits. This excitation is associated with enhanced voluntary performance in patients with incomplete SCI (iSCI). Though there is much we do not know, combining this altered state of exciability with therapy has the potential to enhance the outcomes associated with activity-based interventions. It is a promising tool to augment the work being done in therapeutic settings with the potential to expedite recovery. There is, however, a lag in assimilating the science for clinical practice. This article will examine current literature related to the application of TSCS in combination with therapeutic interventions for motor recovery and aims to elucidate trends in waveform selection, duration and frequency, and combinatorial therapies that may inform clinical practice. With specific consideration for therapeutic settings, potential benefits, applications, and pitfalls for clinical use are considered. Finally, the next steps in research to move toward wider clinical utility are discussed.
Using DNA to Predict How Fast Bacteria can Grow
Authors: Weissman JL , Hou Shengwei , Fuhrman Jed A.
Published: June 2022

Bacteria are single-celled organisms that live out their lives at a microscopic scale. We can find bacteria everywhere we look for them, including inside of our own bodies. Bacteria are incredibly diverse and come in many shapes and sizes. They also vary widely in how they live and grow. Some bacteria grow very quickly and others grow slowly. We wanted to measure the growth of many different types of bacteria in the environment. Unfortunately, some species of bacteria are very difficult to grow in the laboratory. To get around this, we designed a method to predict how fast a type of bacteria can grow, just from its DNA. This way, if we have the DNA of a bacterial species, we can measure its growth even if we cannot get it to grow in our laboratory.
Genotype by Environment Interaction on Tropical Maize Hybrids Under Normal Irrigation and Waterlogging Conditions
Authors: Azrai Muhammad , Efendi Roy , Muliadi Ahmad , Aqil Muhammad , Suwarti  , Zainuddin Bunyamin , Syam Amiruddin , Junaedi  , Syah Uswah Trywulan , Dermail Abil , Marwiyah Siti , Suwarno Willy Bayuardi
Published: June 2022

Unpredictable rainfall in the tropics often increases the risk of waterlogging or even flooding in agricultural lands, hindering the efforts to fulfill maize demands. Breeding maize for waterlogging tolerance is necessary yet challenging since performing varietal testing on a set of hybrids might be biased toward the presence of genotype and environment interaction (GEI). This study aimed to elucidate the GEI effects on yield and related agronomic traits of tropical maize hybrids under normal irrigation and waterlogging conditions and to assess the adaptability of these hybrids in such conditions using several stability models. Ten hybrids including two commercial checks were evaluated across 14 environments under normal and waterlogging conditions in Indonesia from 2018 to 2020. Waterlogging imposed at the V6 stage for ten consecutive days significantly hampered the plant height and ear height, slightly delayed flowering dates, and reduced yield and yield components. The genotype, location, and genotype by location effects were significant on yield, but the genotype by waterlogging effect was not. Stress tolerance index is highly significantly correlated (p < 0.01) with yield in both normal (r = 0.90) and waterlogging (r = 0.96) conditions. The GGE biplot analysis on yield revealed five sectors, two mega-environments, and five vertex genotypes. This study indicated the possibility of breeding maize hybrids tolerant to waterlogging (G05), as well as high-yielding hybrids under both conditions (G07).
Synchronous Operable Pancreatic and Breast Cancer Without Genetic Mutation: A Literature Review and Discussion
Authors: Ofri Adam , Zuidersma Danika , Diakos Connie I. , Stevanovic Amanda , Wong Matthew , Sood Samriti , Samra Jaswinder S. , Gill Anthony J. , Mittal Anubhav
Published: June 2022

Background

Synchronous cancers are rarely detected when working-up a patient for a primary cancer. Neoadjuvant management of synchronous breast and pancreatic cancers, without a germline mutation, has yet to be discussed. Two patients were diagnosed with synchronous breast and pancreatic cancers at our institution over the last decade. A literature review was performed to evaluate the current evidence stance.

Results

The first patient was 61-years old and diagnosed with a HER2+ breast cancer. The second patient was 77-years old and diagnosed with a Luminal B breast cancer. The inability to provide concurrent breast and pancreatic neoadjuvant therapy for the HER2+ patient, resulted in upfront surgery. The second patient was able to have both cancers treated simultaneously - neoadjuvant chemotherapy to the pancreas, and neoadjuvant endocrine therapy to the breast.

Discuss

There is no single neoadjuvant regimen that treats both pancreatic and breast cancer. The differences in breast cancer sub-types impacted our neoadjuvant options. Our recent experience led us to the hypothesis that breast cancer care dictates treatment, while pancreatic cancer determines survival. There is a significant paucity in the literature regarding synchronous breast and pancreatic cancer.
Standardization of Human Metabolic Stoichiometric Models: Challenges and Directions
Authors: Pantziri Marilena D. A. , Klapa Maria I.
Published: June 2022

Genome-scale metabolic network models are of great importance in systems biology research, as they are used in metabolic activity dynamics studies and provide the metabolic level representation in multi-omic investigations. Especially for human, accurate metabolic network reconstruction is important in biomedical research and drug discovery. Today, there exist many instances of the human metabolic network as a whole and in its tissue-specific versions. Some are improved updates of models reconstructed from the same research team, while others are combinations of models from various teams, in an effort to include all available information from genome annotation and omic datasets. A major challenge regarding the human stoichiometric models in particular is the standardization of the reconstruction methods, representation formats and model repositories. Stoichiometric model standardization will enable the educated selection of the model that better fits the goals of a study, the direct comparison of results from various flux analysis studies and the identification of model sections that require reconsideration and updating with respect to the annotation of the human genome and proteome. Standardized human metabolic models aligned to the human genome will be a very useful tool in multi-omic studies, enabling the direct and consistent integration of the metabolic with the gene regulation and protein interaction networks. In this work, we provide a thorough overview of the current collection of human metabolic stoichiometric models, describe the current issues regarding their direct comparison and alignment in the context of the various model repositories, exposing the standardization needs, and propose potential solutions.
The Impact of Rumen-Protected L-Arginine Oral Supplementation on Libido, Semen Quality, Reproductive Organ Biometry, and Serum Biochemical Parameters of Rams
Authors: Hussein Hassan A. , Hassaneen Ahmed S. A. , Ali Montaser E. , Sindi Ramya A. , Ashour Abdallah M. , Fahmy Salem M. , Swelum Ayman A. , Ahmed Ahmed E.
Published: June 2022

This study aimed to investigate the effect of oral supplementation of rumen-protected L-arginine on semen quality, testes, and accessory genital glands biometry in rams. Ten apparently healthy and fertile rams were randomly divided into two equal groups; control, and rumen-protected L-arginine (20 mg/Kg body weight for 30 days) treated group. In all rams, ultrasonographic measurements of the testes and the accessory genital glands and blood sampling were performed at day (D)10, D20, and D30 (D0 is the start of supplementation). Semen ejaculates were collected twice/week and semen quantity, and quality was examined. Our results showed that, in the L-arginine treated group, there were significant increase in the ultrasound biometric measurement of right seminal vesicle (RSV) and right Cowper's gland (RCG) at D10, both testes, tail of the epididymis (TE), SV, and CG of both sides at D20, and of both testes, RTE, RSV, RCG, and LSV at D30. Semen quality and quantity parameters were significantly improved in L-arginine treated group. Moreover, testosterone level in the L-arginine treated group was significantly higher than that in the Control group. Serum thyroxine and glutathione peroxidase concentrations were significantly higher in the L-arginine treated group. The present study concluded that oral supplementation with rumen-protected L-arginine is beneficial in improvement of rams' fertility.
Aeroelastic Tailoring of the Next Generation Civil Tiltrotor Technological Demonstrator Composite Wing
Authors: Marano Aniello Daniele , Belardo Marika , Beretta Jacopo , Starace Filomena , Orlando Salvatore , Punzi Claudio , Frajese Raffaele , Paletta Nicola , Di Palma Luigi
Published: June 2022

The tiltrotor wing structure is one of the most critical and heavily investigated structures in design due to the fundamental need to consider the interactions between the wing, pylon, and rotor systems to achieve aircraft aeroelastic stability. Indeed, in high-speed forward flight, wing flexural and torsional stiffness have fundamental roles in pitch-whirl stability. Another specific concern of tiltrotors is dynamic mode placement; it is necessary to properly place wing bending modes away from prop-rotor forcing frequencies. The main aeroelastic stability and dynamics requirements and the wing design process flow for the next generation civil tiltrotor are presented in this work. In this context, the use of composite materials plays a fundamental role in the attempt to satisfy the requirements, with the perpetual aim of minimizing the structural weight. An overview of the idealized and adopted models for strength, aeroelasticity, and whirl flutter analysis is provided. The primary focus was on the aeroelastic tailoring process. To satisfy, at the same time, all of the structural dynamic and aeroelastic stability requirements, the best compromise, with an acceptable weight penalty, was the mixture of two methodological solutions: adding unidirectional tape in the zones of the upper and lower skins for flexural out-of-plane frequency and adding a proper number of ±45° fabric layers at the locations of the skin with the highest value of strain energy for in-plane torsional modes. The results show that the proposed method based on modal strain energy analysis enables a tiltrotor aeroelastic tailored wing design. It can be easily employed in similar applications (e.g., vehicle scale-up/down) with the advantage of using the stiffness requirements derived directly from the aeroelastic ones (i.e., structural frequencies). The specific wing achieved aeroelastic clearance by adding only 2.7% of extra mass.
Assessing Barriers in Adaptation of Water Management Innovations under Rotational Canal Water Distribution System
Authors: Sajid Imran , Tischbein Bernhard , Borgemeister Christian , Flörke Martina
Published: June 2022

This study assessed problems associated with irrigation water provisions and the potential barriers to the adaptation of the interventions (soil moisture sensors, on-farm water storage facilities and the drip method) under rotational canal water distribution in Punjab, Pakistan. Three groups of stakeholders were individually surveyed during September–December 2020: (i) 72 farmers, (ii) 15 officials, and (iii) 14 academicians. We used descriptive statistical analysis, cross-tabulation and the Fisher test to explore the pattern of responses across the groups. The main problems in the canal water distribution system were expressed by the farmers as limited water allocation, while academicians were concerned mostly with inflexibility and officials indicated discussion among neighbors. According to the farmers’ responses, the conventional depth/interval of irrigation is flooding the field with water and observing the plants, indicating over-irrigation behavior. Moreover, the most important barriers in the adaptation of the interventions that were highly rated by the three groups were low awareness, lack of training and financial resources. Additionally, farmers’ education revealed a statistically significant influence on awareness of soil moisture sensors and water storage facilities, while large farm holders showed a positive relationship to conducting a joint experiment with scientists and farmers’ associations on part of their land to improve water use efficiency.
Seasonal and Feeding System Effects on Qualitative Parameters of Bovine Milk Produced in the Abruzzo Region (Italy)
Authors: Florio Marco , Giannone Claudia , Ianni Andrea , Bennato Francesca , Grotta Lisa , Martino Giuseppe
Published: June 2022

The aim of this study was to examine variations in cow milk composition as a function of breeding system and seasonality. This study was carried out in 16 dairy farms located in the Abruzzo region (Central Italy), equally distributed between farms that adopt grazing in the spring and summer months, and farms where the intensive system is exploited. Milk was sampled in all seasons in each of the farms involved and was analyzed with particular attention given to the quality of the lipid and protein fractions. A lower concentration of saturated fatty acids and an increase in rumenic, vaccenic and oleic acids were registered for milk samples coming from outdoor grazing, in which was also observed the greatest presence of α and β caseins. The opposite result was instead observed for κ casein, which showed the highest values from intensive farming. Evaluations also focused on retinol, which significantly increased in concentration during summer in both breeding systems. The present results suggest positive insights into the role of the outdoor breeding system in improving the main qualitative trait of bovine milk in warm seasons.