bluuebunny/crossref_metadata_2025 huggingface dataset:
Spin-labeling Insights into How Chemical Fixation Impacts Glycan Organization on Cells
Authors: Jaiswal Mohit , Tran Trang T. , Guo Jiatong , Zhou Mingwei , Kunda Sayan , Guo Zhongwu , Fanucci Gail
Published: June 2023

As new methods to interrogate glycan organization on cells develop, it is important to have a molecular level understanding of how chemical fixation can impact results and interpretations. Site-directed spin labeling technologies are well suited to study how the spin label mobility is impacted by local environmental conditions, such as those imposed by cross-linking effects of paraformaldehyde cell fixation methods. Here, we utilize three different azide-containing sugars for metabolic glycan engineering with HeLa cells to incorporate azido glycans that are modified with a DBCO-based nitroxide moiety via click reaction. Continuous wave X-band electron paramagnetic resonance spectroscopy is employed to characterize how the chronological sequence of chemical fixation and spin labeling impacts the local mobility and accessibility of the nitroxide-labeled glycans in the glycocalyx of HeLa cells. Results demonstrate that chemical fixation with paraformaldehyde can alter local glycan mobility and care should be taken in the analysis of data in any study where chemical fixation and cellular labeling occur.
Terrestrial Water Storage Inversion Using Geodetic Measurements to Investigate the Characteristics of Drought in Yunnan, China
Authors: Chen Chao , Zou Rong , Fang Zhiwei , Cao Jiaming , Wang Qi
Published: June 2023

The use of the Global Navigation Satellite System (GNSS) for monitoring changes in terrestrial water storage (TWS) is growing. However, the density of GNSS stations is sparse in most areas, and the widely used Green’s function (GF) method cannot provide a satisfactory resolution for inversion problems. As the Slepian basis function (SBF) method has been successfully used for gravity inversions, GNSS geodesists have recently applied this inversion method to GNSS displacements. However, these inversion results relative to the GF method have seldom been evaluated. In this study, we use the SBF method to investigate the TWS in Yunnan by using more than ten years (2010–2021) of GNSS observations. We find good consistency between the two inversion methods that use GNSS data and strong agreement between water storage estimates based on GRACE, GLDAS, and precipitation datasets, although there are notable differences in amplitude. Furthermore, we also evaluate the connection between GNSS-inverted TWS and major extreme droughts during this period. Because there are thousands of GNSS receivers operating in China, it is possible that GNSS receivers installed for plate deformation studies, surveys, and weather monitoring could also be used to estimate the equivalent water height.
Water treatment-free intermittent hemodialysis: a new approach for kidney replacement therapy in the ICU setting. A retrospective study
Authors: Zucman Noémie , Uhel Fabrice , Verney Charles , Ricard Jean-Damien , Dreyfuss Didier , Roux Damien
Published: June 2023

The optimal modalities of kidney replacement therapy (KRT) in the ICU remain debated. Intermittent hemodialysis (IHD) and continuous veno-venous hemofiltration (CVVH) are the two main methods. Intermittent hemodialysis requires a water treatment system that may not be available in all jurisdictions. We report the experience of an innovative strategy of intermittent KRT without water treatment system.
During the COVID epidemics, the shortage of KRT machines and the transient impossibility of our water treatment system led us to use the Fresenius MultiFiltrate Pro® monitor to achieve IHD in a particular setting. Based on the manufacturer’s recommendations, the dialysate flow during "CVVHDF post" (post-dilution continuous veno-venous hemodiafiltration) mode was increased by connecting the substitution pump in parallel with the dialysate pump using a Y-connector. This allowed doubling the flow rate of dialysate, allowing for 9000 mL/h during intermittent KRT sessions with a blood flow rate of 250 mL/min. We called this technic “water treatment-free intermittent hemodialysis” or WTF-IHD.
We report our experience in 18 patients who underwent 88 WTF-IHD sessions (median duration 5 hours (IQR [4;6]) between August 2019 and May 2020. The median urea reduction ratio was 38% (IQR [29;49]). Hypotension occurred during 21.6% of sessions. Hypokalemia or hypophosphatemia occurred in less than 5% of sessions.
In conclusion, WTF-IHD represents an attractive alternative to conventional IHD when a water treatment system is not available. Despite its lower efficacy compared with IHD, it may have substantial organizational and economic impact.
Hamiltonian cycle embedding with fault-tolerant edges and adaptive diagnosis in half hypercube
Authors: Fan Weibei , Liu Xuanli , Lv Mengjie
Published: June 2023

Interconnection network directly affects the efficiency of parallel and distributed systems. Hypercube is one of the most important interconnection networks in parallel computing systems. As a significant variant of hypercube, half hypercube has the same number of vertices as hypercube while its degree is only half that of hypercube, which indicates that it has lower network overhead than hypercube. In this paper, we study the fault-tolerant embedding of Hamiltonian cycles and design an adaptive diagnosis algorithm for the half hypercube. Firstly, we prove that the half hypercube is Hamiltonian and propose an algorithm to construct a Hamiltonian cycle in the network. Furthermore, we prove that half hypercube is Hamiltonian with no more than (⌈n/2⌉−1) faulty edges. Finally, we present a parallel adaptive diagnosis scheme under PMC model, which can identify almost all faulty vertices in five rounds.
Using Daily Steps to Identify Older Adults with (Un)healthy Joint Profiles of Sedentary Time and Physical Activity: A Starting Point
Authors: Costa Eduardo C. , Freire Yuri A. , Alves Charles P. de Lucena , Cabral Ludmila L.P. , Barreira Tiago V. , Waters Debra L.
Published: June 2023

Herein, we investigated whether daily steps can discriminate between older adults with unhealthy and healthy joint profiles of sedentary time (ST) and moderate-to-vigorous physical activity (MVPA). Apparently healthy community-dwelling older adults aged 60–80 years were included in this cross-sectional analysis (n = 258). Daily steps, ST, and MVPA were assessed by accelerometry. Receiver Operating Characteristic (ROC) analysis was used to test the performance of daily steps in identifying older adults with unhealthy (high ST/low MVPA) and healthy (low ST/high MVPA) joint profiles of ST/MVPA. The cardiovascular disease risk of unhealthy/healthy profiles was compared using a continuous metabolic syndrome score (cMetS). Daily steps discriminated older adults with unhealthy (AUC 0.892, 0.850–0.934; cut-off: ≤5,263 steps/day; sensitivity/specificity: 82.5%/81%) and healthy (AUC 0.803, 0.738–0.868; cut-off: ≥7,134 steps/day; sensitivity/specificity: 79.5%/66.2%) joint profiles of ST/MVPA. The unhealthy profile showed a higher cMetS (β = 0.46; p = 0.008). Likewise, older adults who fell below the daily steps cut-off point to identify the unhealthy profile of ST/MVPA exhibited a higher cMetS (β = 0.34; p = 0.004). In summary, our results provide a starting point for considering daily steps as a single heuristic metric for identifying older adults with a joint profile of high ST/low MVPA, which makes them more susceptible to CVD.
Development of risk prediction model for major amputation in patients with diabetes foot
Authors: Lu Qingwei , Wei Xiaolu , Zhang Wangao , Wang Jun
Published: June 2023

Purpose:A risk prediction model was developed to predict the risk of major amputation in patients with diabetes foot ulcer (DFU) on admission, and instruct patients to prevent and control early, and guide doctors to make clinical decisions.Patients and methods:We used data from the Electronic Medical Record (EMR) database of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from February 2014 to July 2020. DFU patients were divided into major amputation group and non-major amputation group, and nested case-control study method was used to determine case group and control group. The first laboratory tests, imaging examination, complications and other information of DFU patients at admission were collected, and initial predictive variables were selected. Logistic regression and LASSO regression in R software were used to develop a clinical prediction model for DFU patients with major amputation, which was displayed in the form of nomographs, and the model was evaluated by internal validation.Results:A total of 3654 patients were diagnosed as DFU, 695 patients were included in the study on the development of risk prediction model of DFU major amputation, 139 patients in the case group and 556 patients in the control group. 9 variables (WBC, Hb, ALB, Wagner grade, amputation history, smoking, ABI <0.4, ulcer duration >1 month, HbA1c) screened by logistic regression and LASSO regression were used as predictors of major amputation in DFU patients. The internal validation showed that the C index adjusted by Bootstrap method was 0.91 (95% CI, 0.894–0.943), the average absolute error of the prediction model for drawing the calibration curve was 0.01, and the brier score was 0.08.Conclusion:The clinical risk prediction model of major amputation in DFU patients developed in this study has good discrimination and calibration, can accurately predict the outcome events, can be used as an effective tool to guide doctors to make clinical decisions, and enrich and improve the content of DFU prevention and control work, but the promotion and use of the model still needs further verification of external data.
Regulation of the Immune Cell Repertoire in Psoriasis Patients Upon Blockade of IL-17A or TNFα
Authors: Tittes Julia , Brell Jennifer , Fritz Pia , Jonak Constanze , Stary Georg , Ressler Julia Maria , Künig Sarojinidevi , Weninger Wolfgang , Stöckl Johannes
Published: June 2023

Targeting of the pro-inflammatory cytokines interleukin 17A (IL-17A) or tumor necrosis factor alpha (TNFα) with monoclonal antibodies (mAbs) ixekizumab or adalimumab, respectively, are successful therapies in chronic plaque psoriasis. The effects of these treatments on immune cell populations in the skin are largely unknown. In this study, we compared the composition of cutaneous, lesional as well as non-lesional, and blood immune cells in ixekizumab or adalimumab treated patients with psoriasis. Our data reveal that both treatments efficiently down-regulate T-cells, macrophages and different subsets of dendritic cells (DCs) in lesional skin towards levels of healthy skin. In contrast to lesional skin, non-lesional areas in patients harbor only few or no detectable DCs compared to skin of healthy subjects. Neither the treatment with ixekizumab nor adalimumab reverted this DC imbalance in non-lesonal skin of psoriatic patients. Taken together, our study shows that anti-IL-17A as well as anti-TNFα therapy rebalances the immune cell repertoire of lesional skin in psoriatic patients, but fail to restore the disturbed immune cell repertoire in non-lesional skin during the induction phase of therapy.
Bi-specific AutoAntigen-T cell Engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases
Authors: Perico Luca , Casiraghi Federica , Sônego Fabiane , Todeschini Marta , Corna Daniela , Cerullo Domenico , Pezzotta Anna , Isnard-Petit Patricia , Faravelli Silvia , Forneris Federico , Thiam Kader , Remuzzi Giuseppe , Benigni Ariela
Published: June 2023

Identification of targeted therapies for autoimmune diseases is an unmet clinical need. Inspired by the clinical success of targeted immunotherapies in B cell malignancies, here we designed a novel class of recombinant proteins, Bi-specific AutoAntigen-T cell Engagers (BiAATEs), as a potential approach for targeting of autoreactive B cells in antibody-mediated autoimmune diseases for which the pathogenic autoantigen is known.
To test this hypothesis, we focused on a prototype antibody-mediated autoimmune diseases of the kidney, membranous nephropathy (MN), in which phospholipase A2 receptor (PLA2R) serves as primary nephritogenic antigen. Specifically, we developed a BiAATE expressing the immunodominant Cysteine-Rich (CysR) domain of PLA2R, joined to an anti-CD3 single-chain variable fragment by a flexible linker. As such, the BiAATE creates an immunological synapse between autoreactive B cells bearing an CysR-specific surface Ig+ and T cells. Ex vivo, the BiAATE successfully induced T cell-dependent depletion of PLA2R-specific B cells isolated form MN patients, sparing normal B cells. Systemic delivery of BiAATE in mice transgenic for human CD3 effectively reduced anti-PLA2R antibody levels following active immunization with PLA2R.
Collectively, these findings demonstrate the potential of BiAATEs as a promising off-the-shelf therapy for precision medicine in virtually all antibody-mediated autoimmune diseases, leading to a paradigm shift in the treatment of these diseases.
Regulatory Effect of the HMGB1-TLR4 Signaling Pathway in Pulmonary Ischemia/Reperfusion
Authors: Tan Zhaowang , Mao Yunyun , Cai Wenwei , Zheng Yueliang , Li Qian , Zhou Sheng Ang , Tu Jianfeng
Published: June 2023

Background Pulmonary ischemia/reperfusion (I/R) injury derived from hemorrhagic shock-resuscitation is a significant cause of death in trauma patients. However, effective preventive interventions in early trauma resuscitation are lacking.
Aims To investigate the critical role of the HMGB1-TLR4 pathway in the early inflammatory response after ischemia-reperfusion lung injury, and its specific regulatory mechanisms and the types of downstream cytokines regulated by this pathway.
Methods In this study, to determine the molecular mechanism underlying pulmonary I/R injury and identify effective therapeutic targets to reduce the incidence and mortality, the expression of the HMGB1-TLR4 pathway in a pulmonary I/R injury model, its correlation with downstream inflammatory factors, and the effects of HMGB1-neutralizing antibodies on inflammation were evaluated.
Results IL-6 and TNF-α levels in the three mouse models showed a rapid increase， IL-1β, IL-6, and TNF-α were upregulated in alveolar macrophages after LPS stimulation，TNF-α and HMGB1 were upregulated in TLR4+/+ cells and peaked at 48 h but was not upregulated in TLR4-/- cells. Western blot assays revealed that in TLR4+/+ cells, TLR4 was upregulated after stimulation by LPS and was rapidly downregulated after treatment with the HMGB1-neutralizing antibody. In contrast, TLR4-/- cells did not respond to LPS stimulation, and the HMGB1-neutralizing antibody did not significantly alter the TLR4 concentration.
Conclusions HMGB1-TLR4 pathway plays an important role in the regulation of inflammation in pulmonary I/R injury. Furthermore, HMGB1 upregulated downstream inflammatory factors via TLR4. HMGB1-neutralizing antibodies had a protective effect against lung injury by downregulating the inflammatory response.
Modeling the mechanical properties of sustainable mortar modified with waste glass granular (particles) using ANN and multi-scale approaches
Authors: Ahmad Soran Abdrahman , Abdulrahman Alan Saeed , Ramezanianpour Amir Mohammad , Rafiq Serwan Khwrshed , Mahmood Kawa Omar Fqi , Jafer Frya Shawkat
Published: June 2023

Since concrete and mortar production (industry) are the biggest natural resource user, their industry's sustainability are under threat. The environmental and economic concern is the most important challenge that the construction industry is facing. The usage of the waste materials in recent years become interested subject for researchers, one of these waste materials is waste glass usage as sand replacement. This article, dealt with proposing models to predict compressive strength of mortar which modified with waste glass granular, showing its effect on the compressive strength. In this paper, 134 data are collected from previous paper with different parameter and statically analyzed, and represented in four models (Linear regression model (LRM) and non-linear regression model (NLR), multi logistic regression model (MLR) and ANN model) for predicted compressive strength. In the process of modeling, these variables are important and affect on the value of compressive strength, such as curing time, w/c, cement content, sand content, waste glass content. Various statistical assessments such as Root Mean Squared Error (RMSE), Mean Absolute Error (MAE), Scatter Index (SI), OBJ value, and the coefficient of determination (R2) were used to evaluate the efficiency and performance of the proposed models. The obtained results showed that the ANN- model showed better efficiency for predicting the compressive strength of NC mixtures containing fine glass compared to other models.
On the Impact of Atmospheric Turbulence on OOK andBPSK Modulation Schemes for Satcom Optical Uplink
Authors: Medina I , Hernández-Gómez JJ , Couder-Castañeda C
Published: June 2023

The constant growth in the demand for communication services has implied an increase in the amountof information that needs to be transmitted, a situation that has led to the development of newtechnologies for the manipulation of information. Optical satellite communications have provided asolution to this problem, allowing to increase exponentially the transfer rate between the groundstation and an in orbit satellite. However, although this technology offers numerous advantages, suchas higher bandwidth, lower power consumption, narrower beam width, as well as greater simplicity ofdevelopment, it is highly dependent on atmospheric conditions, since the transmitted optical power isseriously affected by absorption and scattering phenomena, as well as by variations in the refractiveindex of the atmosphere due to temperature and humidity variations, among others. In this work,optical power fluctuations are modelled by means of a Gamma-Gamma optical turbulence model, sostrong turbulence conditions are established according to Rytov’s turbulence theory, considering ameasure of the intensity of the optical turbulence when extended to strong fluctuation conditions.Finally, the performance evaluation of BPSK and OOK modulation schemes for conditions withvariations of satellite height, pointing angle, based on atmospheric attenuation, signal scattering andabsorption is given. The results show better performance of the modulation schemes at low zenithpointing angles and large wavelengths (up to the short-wavelength IR). Moreover, BPSK modulationshows to be able to provide lower bit error (BER) values for a given signal-to-noise ratio, outperformingOOK modulation scheme in this sense.
Strongly coupled C@MoSe2@OMWCNT heterostructure as an anode for Na+ batteries
Authors: Yang Yincai , Wang Feng , Biang Mengru , Chen Youwen , Zhang Shiguo , Yu Zhen-Qiang , Au Chak-Tong , Yin Shuang-Feng , Qiu Renhua
Published: June 2023

Herein, based on oxidized multiwall carbon nanotubes (OMWCNTs), C@MoSe2@OMWCNT materials were successfully synthesized. Theoretically, the electron transfer intensity between the interfaces of GR@MoSe2@OSWCNT (oxidized single wall carbon nanotube) is significantly higher than that of C@MoSe2@SWCNT, which means that the interaction between the interfaces of C@MoSe2@OSWCNT is obviously stronger than that of C@MoSe2@SWCNT, improving the structural stability as anode materials for sodium ion batteries (SIBs). In addition, recombination can effectively reduce the Na+ diffusion barrier between MoSe2 layers in the composite (from 0.91 eV to 0.41 eV), promote the Na+ ion mobility of MoSe2 in the composite, and thus improve the rate performance of the SIB. Experimentally, when C@MoSe2@OMWCNT is used as the anode for the SIB, it shows good cycle stability (303 mA h g-1 and 189 mA h g-1 after 500 and 3000 cycles, respectively, under a current density of 5 A g-1).
The effects of probiotic Lactobacillus acidophilus and colchicine on the control of symptoms, duration, and disease progression of mild and moderate cases of COVID-19: A randomized controlled clinical trial
Authors: Hassan Samar Osama Ahmed , Hassan Ahmed Nour El-Din , Mohamed Manal Sabry , Ashram Mohamed Nabil Badawy Al , Nesim Mina Michael , Allam Mohamed Farouk
Published: June 2023

Background
Coronavirus disease 2019 (COVID-19) is a newly emerging human disease caused by a novel coronavirus, causing a global pandemic crisis. Probiotics and/or colchicine may be considered as options for treatment since they have anti-viral, anti-inflammatory, and immunomodulatory effects.
Objective
To assess the effectiveness of probiotic supplements (Lactobacillus acidophilus) and colchicine on symptoms, duration, and progression of mild and moderate cases of COVID-19 infection.
Methods
A three-arm randomized controlled clinical trial was carried out in the triage clinic of the family medicine department at Ain Shams University Hospitals on 150 participants who had been diagnosed as COVID-19 patients with mild and moderate severity. Patients aged below 18 years or above 65 years with any co-morbidities, pregnant or lactating females, and severe COVID-19 confirmed cases were excluded. Randomization was done by using sealed envelopes containing codes for intervention or control. Patients are followed up for improvement of their symptoms with no development of new symptoms over the course of two weeks.
Results
A total of 150 patients with mild and moderate severity of COVID-19 were enrolled in the study, 50 patients in each arm; around one third (34.7%) of the participants were aged between 29 and 39 years; one-quarter (24.7%) were aged between 18 and 28 years and 40.6% were aged 40 years and above. The mean duration of symptoms improvement was 12, 11 and 12 in the colchicine, probiotic, and control groups, respectively. Improvement of inflammatory markers over time occurred in each of the three groups, with no statistically significant difference between them.
Conclusion
Probiotic Lactobacillus acidophilus and colchicine shows no significant effect on the symptoms, duration, and progression of mild and moderate cases of COVID-19.
Computing Independent Dominating Sets in Hypercube Graphs
Authors: Chowdhury Debabani
Published: June 2023

An independent dominating set of a graph is a subset of vertices such that every vertex of the graph is either in he set or adjacent to a vertex in it, and no two vertices of the set are adjacent in the graph. An independent dominating set with the smallest cardinality is called the minimum independent dominating set. The independent domination number is the cardinality of the minimum independent dominating set. Finding a minimum independent dominating set in a graph is an NP-hard problem. This work computes in constant time the minimum independent dominating set in hypercube graph of dimension 2k , k being a positive integer ≥ 1. Furthermore, the independent dominating sets in the n-dimensional hypercube graphs, where 2k < n < 2k+1 −1, k being a positive integer ≥ 1, are computed in linear time. The cardinality of the computed independent dominating set in hypercube graphs of dimensions 2k < n < 2k+1 − 1 satisfies the upper bound of the independent domination number in hypercubes of these dimensions.
Comparative efficacy and economics of selected bio pesticides with Chlorantraniliprole against tomato fruit borer [Helicoverpa armigera (Hubner)] on tomato [Solanum lycopersicum L.]
Authors: Kushal Challagurugula , Kumar Ashwani
Published: June 2023

The field trial was conducted at Central Research Farm, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, UP during Rabi, 2022–2023. The experiment was laid out in RBD (Randomized Block Design). Eight treatments were evaluated against Helicoverpa armigera i.e., (T1) Chlorantraniliprole 18.5% SC (T2) ½Dose Chlorantraniliprole + Nisco sixer plus 2ml/lit (T3) Spinosad 45% SC (T4) Nisco sixer plus 2ml/lit (T5) Neem seed kernel extract 5% (T6) Azadirachtin 5% (T7) Beauvaria bassiana and (T0) untreated Control Were tested to compare the efficacy against Helicoverpa armigera and their influences on yield of Tomato. The best and most economical treatment T1 Chlorantraniliprole 18.5% SC (1:10.), followed by T2 ½Dose Chlorantraniliprole + Nisco sixer plus 2ml/lit (1:10.0) T3 Spinosad 45% SC (1:8.7), T4 Nisco sixer plus 2ml/lit (1:8.1), T5 Neem seed kernel extract 5% (1:6.9), T6 Azadirachtin 5% (1:6.5), T7 Beauvaria bassiana (1:5.8), T0 untreated control (1:4.9) having lowest B:C ratio. Chlorantraniliprole 18.5% SC, ½Dose Chlorantraniliprole + Nisco sixer plus 2ml/lit, Spinosad 45% SC, Nisco sixer plus 2ml/lit recorded the minimum fruit infestation by 8.57, 9.60, 10.66, 11.35 percent respectively. The highest yield was noticed in Chlorantraniliprole 18.5% SC (240.5 q/ha), followed by ½Dose Chlorantraniliprole + Nisco sixer plus 2ml/lit (232.5 q/ha) and Spinosad (200 q/ha).
PRINSIP EKONOMI SYARIAH, IMPLEMENTASI, HAMBATAN DAN SOLUSINYA DALAM REALITAS POLITIK INDONESIA TERKINI
Authors: Mutafarida Binti , Anam Choiril
Published: June 2023

Ekonomi Syariah merupakan ilmu yang terus berkembang mengikuti perkembangan system perekonomian dan juga perkembangan teknologi modern saat ini. Perkembangan ekonomi tidak terlepas dari hambatan yang dihadapi dalam penerapannya di lapangan. Dalam rangka menyelesaikan hambatan yang ada maka diperlukan berbagai perangkat aturan dan juga regulasi. Perkembangan dan dikeluarkannya regulasi juga dapat dipengaruhi oleh system politik yang berlaku. Penelitian ini mencoba mengkaji tentang bagaimana prinsip ekonomi Syariah dalam menghadapi politik saat ini dengan metode kajian literatur. Hasil penelitian yang diperoleh menunjukkan bahwa prinsip ekonomi Syariah yang didukung dengan regulasi sangat penting sebagai salah satu solusi untuk menghadapi hambatan yang ada di masyarakat.
Capital Social, Cooperativismo e Desenvolvimento: Um Estudo em uma Cooperativa de Crédito
Authors: Falkembach Fabiana Regina , Wittmann Milton Luiz , Boff Vilmar Antonio
Published: June 2023

O capital social relaciona-se com a confiança e altruísmo envolvendo comprometimento entre pessoas, no qual o cooperativismo se identifica como organização social assertiva para a sua ampliação e impulsiona o desenvolvimento econômico e cívico de uma comunidade (WEBERING, 2020), embora se constitua como institucionalmente complexo (SILVA; CUBRELLATE, 2019). O presente artigo analisa o cooperativismo a partir da Cooperativa de Crédito – Sicredi União, com o objetivo de verificar processos de participação aliados à cooperação dos associados relativos à: a) sustentabilidade e desenvolvimento; b) capital social; c) transparência e comunicação e d) educação cooperativa. A abordagem metodológica consistiu em um estudo de caso qualitativo exploratório-descritivo com a utilização de dados secundários e de campo obtidos por meio de entrevistas com coordenadores de núcleos da Cooperativa. Como resultados, inferiu-se que a Cooperativa, associada ao ambiente cívico das comunidades, constitui-se como um agente impulsionador do capital social por meio de laços cooperativistas entre os associados e, nesse alinhamento, proporciona a formação e o fortalecimento organizacional de projetos comunitários, embora a pesquisa tenha identificado carências relativas a melhorias em sistemas de transparência e comunicação.
Mobilidade Estudantil como Dinamizadora de Recursividades na Abordagem das Capacitações
Authors: De Lavor Anna Ariane Araujo , Mazzarino Jane Marcia
Published: June 2023

A África é fortemente afetada pela mobilidade humana internacional, que tem, entre outros motivos, a busca por qualificação profissional por meio da educação. O objetivo do presente artigo é analisar a experiência da mobilidade estudantil como possibilidade de desenvolvimento humano, a partir do estudo do caso dos moçambicanos que realizam cursos de Graduação na Universidade da Integração Internacional da Lusofonia Afro-Brasileira (Unilab). Problematiza-se como a mobilidade estudantil possibilita desfrutar das liberdades propostas na Abordagem das Capacitações: liberdade política, facilidades econômicas, oportunidades sociais, garantias de transparência e segurança protetora. O estudo qualitativo e descritivo está ancorado em entrevistas semiestruturadas realizadas com 19 alunos da Unilab em 2020. Os entrevistados, ao optarem pela mobilidade, acessaram uma liberdade de escolha que possibilitou outras liberdades e oportunidades, em um movimento recursivo virtuoso que se reflete não apenas na sua esfera pessoal, como também no desenvolvimento das suas regiões e país de origem. A mobilidade abriu perspectivas de crescimento econômico, social, cultural e político para os estudantes moçambicanos. Evidenciou-se que a mobilidade estudantil dinamizadora de recursividades na Abordagem das Capacitações: do Estado para a pessoa, da pessoa para o Estado e das pessoas entre si.
Avaliação do desenho da política nacional de licenciamento de atividades econômicas: Uma abordagem da lei de declaração de direitos de liberdade econômica
Authors: Almeida Rammyro Leal , Da Costa Carlos Rerisson Rocha
Published: June 2023

O licenciamento das atividades econômicas é uma ação permanente de Estado, exercida no uso de seu poder regulatório, que encontra fundamento na própria Constituição da República. O presente artigo analisa a consistência e a coerência do desenho da política nacional de licenciamento das atividades econômicas, especificamente da estrutura de classificação normativa de risco para fins licenciatórios, a partir da Lei nº 13.874, de 20 de setembro de 2019, instituidora da Declaração de Direitos de Liberdade Econômica. A presente avaliação de desenho envolve a utilização de fontes documentais e a coleta de dados em processos legislativos e documentos normativos, para caracterização e descrição da política avaliada. A conclusão sinaliza para a verificação de coerência dentro da política avaliada em relação à sua racionalidade voltada para o controle e diminuição do aparelho burocrático. Foram constatadas, entretanto, inconsistências de ordem instrumental no desenho da política, tais como o excesso de terminologias utilizadas na descrição dos níveis de risco das atividades econômicas, constante na Resolução CGSIM nº 51, de 2019. A quantidade de termos de forma desnecessária pode acarretar confusão e falta de clareza no uso das nomenclaturas durante a execução da política.
BIOMARCADORES ORGÂNICOS E INORGÂNICOS DE AEROSSÓIS ATMOSFÉRICOS DE REGIÕES MARINHAS
Authors: Martinez Sabrina , dos Anjos Jeancarlo , Pereira Pedro , Guarieiro Lilian , da Rocha Gisele
Published: June 2023

ORGANIC AND INORGANIC BIOMARKERS OF ATMOSPHERIC AEROSOLS FROM MARINE REGIONS. In this study, we overview the recent advancements in knowledge regarding organic and inorganic biomarkers of atmospheric aerosols from coastal zones and open marine areas. It deals with the interaction between the ocean and the atmosphere through their interface, the formation of a seawater microlayer (SML) and the exchange of a myriad of chemical compounds between those environmental compartments. We also discuss how marine aerosols (MAs) are intrinsically related to the global carbon cycle, influence the radiative budget of the Earth, and are related to global climate. At the end, we discuss the trends of new studies on the topic.
Synthesis, in vitro Toxicity, and Antitrypanosomal Activity of Arylated and Diarylated Thiazoles
Authors: Figueira Kelly , Girão Roberson , da Costa Krislayne , Barreto Ana , Soeiro Maria de Nazaré , Limberger Jones
Published: June 2023

Chagas disease is a relevant public health threat that affects over 6 million people worldwide, resulting in devastating social and economic consequences. Moreover, the therapeutic options are limited, highlighting the urgency in searching for novel active antitrypanosomal molecules. Compounds with either thiazole or biaryl units have been described as possessing anti-Trypanosoma cruzi activities. Therefore, here, we describe the synthesis of nine arylated and diarylated thiazole derivatives and the evaluation of their in vitro toxicity on mammalian cells as well as their anti-T. cruzi activity. The compounds were prepared in straightforward synthetic routes, using Hantzsch thiazole synthesis and cross-coupling reactions as key steps. A pyridylphenyl-thiazole (PPT) derivative (4c) presented 76% of T. cruzi growth inhibition in preliminary tests using a fixed concentration of 20 µM. This compound was used as a scaffold for the synthesis of two novel PPT analogs (4g and 4h). Dose-response assays on intracellular forms of T. cruzi demonstrated that these three compounds presented high antiparasitic potency (half maximal effective concentration (EC50) values ranging from 1.15 to 2.38 μM) and low toxic profile against L929 cell lines. Hence, these findings highlight the pyridyl-phenyl-thiazole backbone as a novel privileged scaffold in the search for active molecules against T. cruzi.
Responses of activated sludge under a short-term exposure to facial scrub microbeads: implications from treatment performance and higher-life microbial population dynamics
Authors: Yazdanbakhsh Ahmadreza , Rafiee Mohammad , Mohammadi Zahra
Published: June 2023

In this study, four identical laboratory-scale sequencing batch reactors (SBRs) were continuously operated with different concentrations of microbeads (MBs) (5,000–15,000 MBs/L) to investigate the stress-responses of activated sludge under the MB exposure. It was found that the overall treatment performance (organic removal) of SBRs was fairly affected by short-term exposure to low levels of MBs; however, it was adversely affected as the concentration of MBs increased. The average concentration of mixed liquor suspended solids and heterotrophic bacteria in the reactor fed with 15,000 MBs/L were 16 and 30% less than in the pristine control reactor, respectively. Batch experiments further demonstrated that fairly low concentrations of MBs favored the development of dense microbial structures. Further increasing the MB concentrations to 15,000 MBs/L, however, distinctly weakened the settling performance of sludge. Morphological observations revealed suppressed uniformity, strength, and integrity of flocs reactors with the addition of MBs. Microbial community analyses revealed that the abundance of protozoan species declined 37.5, 58, and 64%, respectively, when SBRs were exposed to 5,000; 10,000; and 15,000 MBs/L as compared with the control reactor. The present work provided new insight into the possible effects of MBs on the performances and operational parameters of activated sludge.
Heroísmo comum
Authors: Torres de França Fagner , Gomes da Silva Patrícia Rilliane , Lopes Almeida Luzia Cristina
Published: June 2023

Neste trabalho, elaborado entre julho e dezembro de 2019, foram investigadas as relações entre a formação acadêmica e a saúde mental entre pós-graduandos(as) do Programa de Pós-Graduação em Ciências Sociais da Universidade Federal do Rio Grande do Norte. Trabalhamos com o relato de seis pessoas, entre mestrandos(as) e doutorandos(as) do Programa, procurando observar ao máximo a heterogeneidade dos(as) participantes. A pesquisa contempla ainda revisão bibliográfica da produção acerca do tema no Brasil. Utilizamos metodologia qualitativa baseada em história de vida, grupo focal e entrevista isolada em profundidade, no sentido de apresentar o fenômeno com mais densidade e complexidade. Na maioria dos relatos, independente do extrato social, o sofrimento psíquico foi relacionado às dificuldades socioeconômicas do país, às dúvidas acerca do futuro das Ciências Sociais no Brasil, ao medo do desemprego, ao isolamento acadêmico, à forte competitividade, à cultura organizacional do próprio Programa e às exigências produtivistas, caraterísticas da sociedade contemporânea.
The hypoglossus nerve (XII cranial nerve pair): anatomical considerations and complications after injuries – a literature review
Authors: Felipe Celestrin de Toledo  , Beatriz Carmona Ferreira-Pileggi  , Alexandre Rodrigues Freire  , Felippe Bevilacqua Prado  , Ana Cláudia Rossi
Published: June 2023

The hypoglossal nerve (XII cranial nerve) is the tongue’s motor supply. The hypoglossal nerve trajectory can be separated into two main parts: intracranial and extracranial. Objective: Considering the rarity of hypoglossus nerve injury, and that when it occurs it results in clinical implications that should be known by the Medical and Dentistry professionals, the aim of this study was to carry out a literature review on the anatomy of the hypoglossal nerve and possible causes of injuries and ways to treat this type of complication. Material and methods: A literature review was carried out in the international Pubmed database. The literature review included 19 articles from 1965 to 2021. The keywords used were: “hypoglossus nerve”, “injury”. Of the 19 articles, 10 were used for this literature review. Among the 9 articles that were discarded, 5 did not address the objective of this work and 4 did not present the available text. All types of articles were considered (1 literature review, 6 case reports and 3 original articles). Conclusion: The knowledge of the hypoglossal nerve anatomy is for surgical interventions, partial resections, and tongue reconstructions. The causes listed in the present literature review are intubation, the covid-19, procedures performed in the carotid area and occipital condyle fracture. In relation to treatment approaches, no specific protocol has been invented until now.
Educação em saúde bucal e as diferentes fases da vida – uma revisão da literatura
Authors: Lorrayne da Cruz Gonçalves  , Angela Scarparo
Published: June 2023

Uma comunidade corretamente informada é capaz de tomar atitudes conscientes com relação à própria saúde. Entretanto o desconhecimento das individualidades e singularidades de cada ciclo vivido pode dificultar o processo de transmissão do conhecimento. Objetivo: Pontuar as características favoráveis e desfavoráveis evidentes na infância, adolescência, idade adulta e terceira idade que devem ser consideradas no que diz respeito à educação em saúde bucal. Material e métodos: Trata-se de uma revisão narrativa da literatura. Para tanto, as bases de dados PubMed, BBO (Lilacs), Scopus, SciELO e Google Scholar foram utilizadas. Os trabalhos dos últimos 10 anos foram analisados por meio dos seguintes critérios: texto completo disponível de forma gratuita, título, resumo e idioma (inglês, português e espanhol). Ainda, eles deveriam obrigatoriamente se relacionar com educação em saúde, trazer algum conhecimento ou percepção sobre os estágios da vida ou apresentar ensinamentos relativos ao processo de aprendizagem ou letramento. Revisão da literatura: Após análise dos dados tabulados, observou-se que cada fase da vida é marcada por características próprias e que precisam ser respeitadas. Nesse sentido, a educação bucal em saúde envolve mais do que transmitir informações relacionadas à saúde; é importante que haja o conhecimento do público e contexto social envolvido. Conclusão: A infância inclui características favoráveis, como o intenso desenvolvimento cognitivo, físico e emocional, acrescido do aprimoramento e das conquistas de habilidades motoras. Os pontos desfavoráveis incluem: alimentação rica em carboidratos, falta de conhecimentos dos pais sobre os mecanismos de prevenção da cárie e necessidade de ajuda para a higienização bucal. Para a adolescência, as características favoráveis são: rápida capacidade de aprendizagem, adaptação e desenvolvimento neurobiológico, características afetivas e visuais aumentadas. Já as desfavoráveis se apresentam como a maturidade ainda em desenvolvimento e o enfrentamento de situações de vulnerabilidade. Já os adultos e a terceira idade são receptivos e multiplicadores de informação. Os declínios em relação à função cognitiva e grau de dependência para a realização de atividades cotidianas são os aspectos a serem superados.
Histomorfometria óssea: uma análise entre as técnicas com metacrilato de metila e parafina
Authors: Barbara Lais de Albuquerque  , Mariana Campos Ferreira  , Letícia Capote dos Santos  , Carolina Aguiar Moreira  , Maria Carolina Botelho Pires de Campos  , Cintia Mussi Milani  , Isabela Ribeiro Madalena  , Flares Baratto-Filho  , Liliane Roskamp
Published: June 2023

A histomorfometria permite um estudo quantitativo da microscopia óssea, a fim de obter parâmetros estruturais e de formação e remodelação óssea. Objetivo: Realizar uma revisão integrativa da literatura e comparar as técnicas de histomorfometria óssea realizada por meio da emblocação da peça óssea em parafina e emblocação da peça óssea em metacrilato de metila (MMA). Material e métodos: Trata-se de um estudo exploratório descritivo de carácter integrativo. As bases de dados Educational Resources Information Center, Scientific Electronic Library Online (SciELO), PubMed/Medline, Periódicos Capes/ MEC e Cochrane Library foram utilizadas para busca. Os critérios de inclusão foram pesquisas originais de estudos observacionais de caso-controle, estudos experimentais clínicos, revisões sistemáticas com e sem metanálises. Revisão de literatura: A histomorfometria aprofunda a análise histológica porque avalia estruturas de forma bidimensional e tridimensional. A histomorfometria óssea destaca-se por avaliar desde parâmetros estáticos, quando se usa a parafina, e dinâmicos, quando se utiliza o MMA. Conclusão: A técnica com o uso do MMA é considerada padrão ouro por ser uma análise dinâmica do tecido ósseo não descalcificado.
Importância do atendimento odontológico durante a pandemia de covid-19 – relato de caso clínico COE/Univille
Authors: Ana Carolina Barbosa dos Santos  , Ana Flávia Ortiz Chiarello  , Susimara Braga de Almeida  , Timothy Ernst Furlong
Published: June 2023

A pandemia de covid-19 exigiu mudanças no protocolo de biossegurança no atendimento odontológico. Isso porque os dentistas foram classificados como grupo de risco. Tal situação pode ser observada por meio do relato de caso clínico da Clínica de Odontologia Especializada (COE) da Universidade da Região de Joinville (Univille), em Joinville (SC). Objetivo: Ressaltar a importância de um novo protocolo de atendimento para prevenir a contaminação do coronavírus. Relato de caso: Paciente, 36 anos, relatou “dor no dente”. Foi encaminhada da UBSF Jardim Paraíso I e II para a COE/Univille para realização de um tratamento de canal no dente 46, que estava aberto e com lesão cariosa. No exame radiográfico constatou-se espessamento do ligamento periodontal. Efetuou-se a endodontia, e as consultas posteriores foram adiadas por conta da paralisação nacional, a fim de evitar a disseminação da covid-19, sem a finalização do tratamento restaurador. Conclusão: Durante a pandemia foi necessária a adesão de um novo protocolo de biossegurança para reduzir a contaminação cruzada proveniente da covid-19 e assegurar atendimento odontológico seguro e resolutivo.
Desenvolvimento de dois produtos criogênicos à base de camomila (Matricaria recutita) e malva (Malva Ssylvestris): uma alternativa de tratamento para mucosite oral
Authors: Everton Thiago Luz  , José Henrique Dias  , Constanza Marín de los Ríos Odebrecht  , Celia Maria Condeixa de França Lopes  , Daniel André Lopes  , Luiz Carlos Machado Miguel  , Jussara Maria Gonçalves
Published: June 2023

A quimioterapia configura-se como um dos principais recursos terapêuticos no tratamento das neoplasias malignas infantojuvenis. Entretanto certos quimioterápicos apresentam toxicidade, gerando efeitos colaterais, como a mucosite oral. Tal condição se caracteriza como úlceras dolorosas que resultam em disfagia, infecções secundárias e, em casos extremos, interrupção do tratamento. Objetivo: Criar uma alternativa de tratamento para a mucosite oral em pacientes oncológicos pediátricos: terapia criogênica à base de fitoterápicos. A proposta tem o intuito de associar os benefícios da crioterapia, consolidados na literatura, às propriedades anti-inflamatórias de fitoterápicos. Material e métodos: Foram desenvolvidos dois sorvetes: malva (M. sylvestris) com chocolate (sorvete A) e camomila (Matricaria recutita) com frutas vermelhas (sorvete B). Após a distribuição e degustação dos sorvetes, realizaram[1]se perguntas por meio de um questionário, de modo a analisar a aceitação e recomendação de ambos os produtos por parte dos pacientes. Resultados: O sorvete A obteve nota média na avaliação do sabor de 8,24, já o sorvete B alcançou 7,12. No quesito de indicação dos sorvetes, o A teve indicação de 88% dos pacientes e o sorvete B, 60%. Por fim, o sorvete A teve maior predileção (64%) em relação ao sorvete B (36%). Conclusão: Os resultados encontrados neste estudo sugerem que a utilização de um sorvete à base de camomila e malva apresenta uma boa aceitação pelos pacientes oncológicos pediátricos. No entanto mais estudos são necessários para que haja a validação clínica dos produtos desenvolvidos.
Avaliação da resistência de adesão de pinos de fibra de vidro à dentina radicular de dentes humanos extraídos submetidos a diferentes formas de armazenamento
Authors: Lara Dalla Vecchia Beira  , Rebecca Grechuski Antunes  , Luciano Madeira
Published: June 2023

A restauração de dentes tratados endodonticamente constitui um desafio clínico em virtude da perda da estrutura dental. Para reestabelecer o suporte coronário, torna-se essencial o uso de retentores intrarradiculares. A fim de manter as estruturas dentais, suas respectivas propriedades e garantir o correto desenvolvimento das pesquisas in vitro, diferentes formas de armazenamento de dentes humanos extraídos foram estudadas para relacionar os efeitos sobre as mais diferentes propriedades dentinárias. No entanto não foram encontrados estudos que avaliaram os efeitos sobre a resistência de adesão de pinos de fibra de vidro cimentados à dentina radicular. Objetivo: Realizar a análise da resistência de adesão de pinos de fibra de vidro cimentados à dentina radicular de dentes humanos extraídos, por meio do teste de pull-out, submetidos a diferentes condições de armazenamento. Material e métodos: Utilizaram-se 24 dentes unirradiculares recém-extraídos, armazenados de diferentes formas, conforme segue: grupo [A] – armazenados em congelador de geladeira; grupo [B] – armazenados em formol 10% durante 15 dias; e grupo [C] – esterilizados em autoclave. Os canais radiculares foram preparados com limas rotatórias e obturados com guta-percha e cimento à base de óxido de zinco e eugenol. Após 24 horas realizou-se o preparo dos condutos com broca do sistema de pinos de fibra de vidro e procedeu-se a limpeza dos preparos com o uso do microscópio e pontas ultrassônicas. Em seguida, os pinos foram cimentados com cimento resinoso AllCem dual e submetidos ao teste de pull-out em uma máquina de ensaios EMIC DL500. Resultados: Os dados foram analisados estatisticamente pelo teste não paramétrico de Kruskal Wallis, que não detectou diferenças estatisticamente significativas entre os grupos experimentais. Conclusão: A esterilização em autoclave e/ou desinfecção em formol 10% não afetam a resistência de adesão do pino de fibra de vidro à dentina radicular.