bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing the Rheological and Textural Properties of Chapatti Enriched with House Crickets (Acheta domesticus) Flour Using Hydrocolloids by an I-Optimal Design
Authors: Khatun Habiba , Lievens Siebe , Smets Ruben , Akhtaruzzaman Mohammad , Van Der Borght Mik , Claes Johan
Published: November 2022

The fortification of food with edible insect flour can improve its nutrition profile, but also affect its techno-functional characteristics. In this study, an I-optimal design was applied to improve the rheological and textural properties of wheat flour chapatti containing 10% cricket (Acheta domesticus) flour. More specifically, the impact and optimal addition of hydrocolloids (carboxymethyl cellulose, hydroxypropyl methylcellulose, guar gum and xanthan gum) and water content were studied. For all the responses, the model and model terms were highly significant and showed the different impact of the hydrocolloids on the rheological properties. To evaluate the predictive power of the models, two sets of optimal process settings were chosen: one based on dough properties, and another on baked chapatti. For both sets, the actual responses were in the range of predicted responses for almost all properties. In addition, it was shown that using the settings based on dough properties, the actual responses were not significantly different from the control chapatti, whereas for the settings based on baked chapatti, there were differences in terms of the extensibility of both dough and chapatti. Thus, the I-optimal design is suitable to optimize the dough properties and the baked chapatti when enriching chapatti with cricket flour.
Asymptomatic Carriage of Listeria monocytogenes by Animals and Humans and Its Impact on the Food Chain
Authors: Schoder Dagmar , Guldimann Claudia , Märtlbauer Erwin
Published: November 2022

Humans and animals can become asymptomatic carriers of Listeria monocytogenes and introduce the pathogen into their environment with their feces. In turn, this environmental contamination can become the source of food- and feed-borne illnesses in humans and animals, with the food production chain representing a continuum between the farm environment and human populations that are susceptible to listeriosis. Here, we update a review from 2012 and summarize the current knowledge on the asymptomatic carrier statuses in humans and animals. The data on fecal shedding by species with an impact on the food chain are summarized, and the ways by which asymptomatic carriers contribute to the risk of listeriosis in humans and animals are reviewed.
Summer Buffalo Milk Produced in China: A Desirable Diet Enriched in Polyunsaturated Fatty Acids and Amino Acids
Authors: Nie Pei , Pan Bin , Ahmad Muhammd Jamil , Zhang Xinxin , Chen Chao , Yao Zhiqiu , Lv Haimiao , Wei Ke , Yang Liguo
Published: November 2022

The objective of the study was to compare and reveal differences in basic chemical parameters, fatty acids, amino acids, and lipid quality indices of crossbred buffalo (swamp x river type) milk produced in summer and winter. The buffalo milk samples were collected in summer (Jul–Aug) and winter (Dec–Jan) from Hubei province, China. The samples were detected by using CombiFoss apparatus, gas chromatography, and an automated specialized amino acid analyzer. The results showed that the basic chemical parameters, fatty acid profiles, lipid quality indices, and amino acid profiles of crossbred buffalo milk differed between summer and winter. Specifically, summer buffalo milk exhibited a higher content of MUFA (monounsaturated fatty acids) and PUFA (polyunsaturated fatty acids) than winter buffalo milk. Summer buffalo milk had a lower content of major SFA (saturated fatty acids), a higher content of ω-3 and DFA (hypocholesterolemic fatty acids), a lower ω-6/ω-3 ratio, a higher value of 3 unsaturated fatty acid indices (C14, C16, C18), and a lower value of IA (index of atherogenicity) and IT (index of thrombogenicity) than winter buffalo milk. Additionally, 17 amino acids, including 8 EAA (essential amino acids) and 9 NEAA (non-essential amino acids) were higher in summer buffalo milk. These results indicated that summer buffalo milk was more health-beneficial than winter buffalo milk. Therefore, summer buffalo milk might be a desirable diet option for human nutrition and health. Our findings provide valuable information for the research and development of buffalo dairy products in China or other Asian countries.
Safety and Quality of Milk and Milk Products in Senegal—A Review
Authors: Leone Cortney , Thippareddi Harshavardhan , Ndiaye Cheikh , Niang Ibrahima , Diallo Younoussa , Singh Manpreet
Published: November 2022

Historically, local milk production in Senegal has struggled to keep up with the demands of consumers, so there has been a heavy reliance on imported milk and milk products. More recently, efforts have been made to improve local dairy production by establishing large, organized dairies that collect milk from rural production areas and developing small-scale processing units, such as mini dairies. The local dairy value chain in Senegal consists of (1) informal collection systems where farmers commonly deliver milk directly to dairies; (2) traditional and artisanal processing using simple equipment and techniques; and (3) short local marketing and sale circuits. Most West African dairy sectors are dominated by raw, unpasteurized milk or traditional, spontaneously fermented milk products, such as lait caillé in Senegal, sold through small-scale channels without a cold chain, so the risk of food safety hazards may be increased. Microbiological, chemical, and physical hazards have been found in milk and milk products across West Africa. There is a need to educate milk producers, small-scale processors, and vendors on the importance of refrigerating milk immediately after milking as well as maintaining the cold chain until the milk is heat treated and, subsequently, until the milk is marketed to the consumer. However, without assistance, obtaining the equipment necessary for cold storage and processing of milk can be challenging.
The Effects of Ethanol and Rutin on the Structure and Gel Properties of Whey Protein Isolate and Related Mechanisms
Authors: Jia Na , Lin Shiwen , Yu Yuzhen , Zhang Guangyao , Li Lingli , Zheng Duoduo , Liu Dengyong
Published: November 2022

The effects of different levels of rutin (0, 0.05%, 0.1%, 0.2% and 0.3% w/v) and ethanol on the structure and gel properties of whey protein isolate (WPI) were examined. The results showed that the addition of ethanol promoted the gel formation of WPI. The addition of rutin increased the gel strength of WPI and maintained the water-holding capacity of the gel. Ethanol caused an increase in thiol content and surface hydrophobicity, but rutin decreased the thiol content and surface hydrophobicity of WPI. The particle size, viscosity and viscoelasticity of WPI increased at rutin levels of 0.2% and 0.3%, indicating that rutin caused cross-linking and aggregation of WPI, but rutin had no significant effect on the zeta-potential, indicating that electrostatic interactions were not the main force causing the changes in protein conformation and gel properties. Ethanol and rutin improved the gel properties of WPI possibly by inducing cross-linking of WPIs via hydrophobic and covalent interactions.
Inhibitory Effect of Dietary Defatted Rice Bran in an AOM/DSS-Induced Colitis-Associated Colorectal Cancer Experimental Animal Model
Authors: Tajasuwan Laleewan , Kettawan Aikkarach , Rungruang Thanaporn , Wunjuntuk Kansuda , Prombutara Pinidphon , Muangnoi Chawanphat , Kettawan Aurawan Kringkasemsee
Published: November 2022

Defatted rice bran (DRB) is gaining immense popularity worldwide because of its nutritional and functional aspects. Emerging evidence suggests that DRB is a potential source of dietary fiber and phenolic compounds with numerous purported health benefits. However, less is known about its chemoprotective efficacy. In the present study, we determined and examined the nutrient composition of DRB and its chemopreventive effect on azoxymethane and dextran sulphate sodium (AOM/DSS)-induced colitis-associated colorectal cancer (CRC) in rats. The results showed the presence of several bioactive compounds, such as dietary fiber, phytic acid, and phenolic acids, in DRB. In addition, DRB supplementation reduced the progression of CRC symptoms, such as colonic shortening, disease activity index (DAI), and histopathological changes. Interestingly, a significant decrease was observed in total numbers of aberrant crypt foci (ACFs) and tumors with DRB supplementation. Furthermore, DRB supplementation suppressed the expression of pro-inflammatory cytokines (IL-6) and inflammatory mediators (NF-κB and COX-2) through the inactivation of the NF-κB signaling pathway. The administration of DRB revealed a negative effect on cancer cell proliferation by repressing the expression of nuclear β-catenin, cyclin D1, and c-Myc. These findings suggest that DRB supplementation mitigates chronic inflammation and cancer cell proliferation and delays tumorigenesis in rat AOM/DSS-induced colitis-associated CRC. Therefore, the establishment of DRB as a natural dietary food-derived chemopreventive agent has the potential to have a significant impact on cancer prevention in the global population.
Preventing Microbial Infections with Natural Phenolic Compounds
Authors: Ecevit Kardelen , Barros Alexandre A. , Silva Joana M. , Reis Rui L.
Published: November 2022

The struggle between humans and pathogens has taken and is continuing to take countless lives every year. As the misusage of conventional antibiotics increases, the complexity associated with the resistance mechanisms of pathogens has been evolving into gradually more clever mechanisms, diminishing the effectiveness of antibiotics. Hence, there is a growing interest in discovering novel and reliable therapeutics able to struggle with the infection, circumvent the resistance and defend the natural microbiome. In this regard, nature-derived phenolic compounds are gaining considerable attention due to their potential safety and therapeutic effect. Phenolic compounds comprise numerous and widely distributed groups with different biological activities attributed mainly to their structure. Investigations have revealed that phenolic compounds from natural sources exhibit potent antimicrobial activity against various clinically relevant pathogens associated with microbial infection and sensitize multi-drug resistance strains to bactericidal or bacteriostatic antibiotics. This review outlines the current knowledge about the antimicrobial activity of phenolic compounds from various natural sources, with a particular focus on the structure-activity relationship and mechanisms of actions of each class of natural phenolic compounds, including simple phenols, phenolic acids, coumarin, flavonoids, tannins, stilbenes, lignans, quinones, and curcuminoids.
Prestressed Composite Polymer Gels as a Model of the Extracellular-Matrix of Cartilage
Authors: Chremos Alexandros , Douglas Jack F. , Basser Peter J. , Horkay Ferenc
Published: November 2022

Articular cartilage is a composite hydrogel found in animal and human joints, which exhibits unique load-bearing properties that have been challenging to reproduce in synthetic materials and model in molecular dynamics (MD) simulations. We computationally investigate a composite hydrogel that mimics key functional properties of articular cartilage as a potential biomimetic model to investigate its unique load-bearing properties. Specifically, we find that the emergence of prestress in composite gels derives primarily from the stiffness of the polymer matrix and the asymmetry in the enthalpic interactions of the embedded particles and polymer matrix. Our MD simulations of the development of prestress agree qualitatively with osmotic pressure measurements observed in our model composite hydrogel material.
Development and Evaluation of PLGA Nanoparticle-Loaded Organogel for the Transdermal Delivery of Risperidone
Authors: Dilawar Naz , Ur-Rehman Tofeeq , Shah Kifayat Ullah , Fatima Humaira , Alhodaib Aiyeshah
Published: November 2022

A transdermal delivery approach may circumvent the limitations associated with the oral use of risperidone (RIS), an atypical antipsychotic drug. The current study focuses on the utilization of poloxamer (pluronic) lecithin organogel (PLO), a suitable transdermal vehicle, and a biodegradable nanoparticulate system of PLGA with the potential to deliver RIS in an efficient way. PLGA nanoparticles were fabricated using different ratios of the polymer and surfactant. The optimization was performed principally on the basis of particle size and entrapment efficiency (EE). The developed PLGA nanoparticles were spherical, sized around 109 nm with negative charge (−9.3 mv) and enhanced drug entrapment efficiency (58%). The in vitro drug release study of lyophilized nanoparticles showed a sustained pattern. Statistical analysis confirmed that there was a significant difference (p < 0.05) between the nanoparticle-loaded PLO gel and conventional drug formulations in terms of drug release and ex vivo permeation across rat skin (three-fold). The results confirm enhanced drug release and permeation through the skin at 72 h. Hence, the investigated formulation could be a better alternative to the conventional route for improving patient compliance.
The Effect of Visualization Techniques on Students of Occupational Therapy during the First Visit to the Dissection Room
Authors: Criado-Álvarez Juan José , Romo-Barrientos Carmen , Zabala-Baños Carmen , Martínez-Lorca Manuela , Viñuela Antonio , Ubeda-Bañon Isabel , Flores-Cuadrado Alicia , Martínez-Lorca Alberto , Polonio-López Begoña , Mohedano-Moriano Alicia
Published: November 2022

Background: Part of the basic teaching of human anatomy are prosection sessions with a human corpse, which may generate stress or anxiety among students. The objective of this work was to study how, through the visualization technique (a coping technique), these levels could be reduced before starting prosection classes. Methods: A cross-sectional pilot study was conducted involving first-year students who had never participated in screening sessions. Prior to the visit, occupational therapy students underwent a viewing session (visualization technique). On the day of the visit, before and after the screening session, an anonymous questionnaire was distributed to find out about aspects of the students’ experiences, such as their feelings and perceptions. The State–Trait Anxiety Inventory was used to assess anxiety. Results: The baseline levels of anxiety measured remained stable (from 18.5 to 18.2 points), with no differences being found (p > 0.05). The levels of emotional anxiety measured fell from 15.2 to 12.6 points (p < 0.05). Before starting the class, there were six students (17.1%) with anxiety criteria, and this figure was doubled at the end of the session (33.3%) (p < 0.05). Conclusions: Sessions in a dissection room can cause stressful experiences and change the emotional balances of some students. The results obtained and published here showed no significant differences after the visualization technique. We found that the students believed that the prosection sessions were very useful for teaching anatomy.
Peripheral Arterial Compression as a New Adjunct Technique to Cardiopulmonary Resuscitation
Authors: Quinn Kristen M , Hardy William A , Seigler Samuel W , Holman Heather L , Kwon Jennie H , Rajab Taufiek Konrad
Published: November 2022

The success of cardiopulmonary resuscitation (CPR) is critically dependent on the maintenance of myocardial and cerebral perfusion; therefore, preferential perfusion of these vital organs over non-vital vascular beds, such as the extremities, is desirable. We propose that compression of the femoral and/or brachial arteries during CPR improves resuscitation outcomes.
What Do We Know So Far about Ofatumumab for Relapsing Multiple Sclerosis? A Meta-Analytical Study
Authors: Taj Hafiza Munazza , Talib Maryam , Siddiqa Sania , Sarfraz Azza , Sarfraz Zouina , Robles-Velasco Karla , Cherrez-Ojeda Ivan
Published: November 2022

Ofatumumab is a monoclonal antibody that reduces the level of B cells that alter the progression of relapsing multiple sclerosis. Originally approved by the Food and Drug Administration (FDA) in August 2020, this meta-analysis determines the outcomes of four randomized controlled trials (RCTs) for endline outcomes of Gadolinium-enhancing T1 lesions on MRI scans reported as Cohen’s d and relapse rate reported as risk ratio. All four RCTs reported favorable findings of gadolinium-enhancing T1 lesions (Cohen’s d = −0.44, p < 0.00001). The relapse rate was reduced by 46% post ofatumumab administration (RR = 0.54, p < 0.00001). With 14 ongoing trials in this area, more data is required to consolidate our findings.
Effectiveness of Educational Interventions to Increase Skills in Evidence-Based Practice among Nurses: The EDITcare Systematic Review
Authors: Portela Dos Santos Omar , Melly Pauline , Hilfiker Roger , Giacomino Katia , Perruchoud Elodie , Verloo Henk , Pereira Filipa
Published: November 2022

Background: Using evidence-based practice (EBP) improves the implementation of safe, high-quality healthcare for patients, reduces avoidable costs, and plays a crucial role in bridging knowledge–action gaps and reducing health inequities. EBP combines the best available evidence in the relevant literature with patient preferences and values and healthcare professionals’ (HCPs) expertise. Methods: Systematic searches of ten bibliographic databases, unpublished works, and the Grey Literature Report sought studies published up to 30 September 2022. Results: The 15 studies retained involved 2712 nurses. Three types of effective educational interventions were identified: (1) multifaceted educational strategies incorporating mentoring and tutoring; (2) single educational strategies, often delivered online; and (3) multifaceted educational strategies using the five steps of EBP. Eleven primary outcomes (EBP beliefs, EBP self-efficacy, perceived EBP implementation, EBP competencies, EBP knowledge, EBP skills, EBP attitudes, EBP behaviors, EBP desire, EBP practice, and perceptions of organizational culture and readiness) were assessed using 13 qualitative and quantitative instruments. Conclusions: Ensuring the successful implementation of EBP requires effective educational strategies. Computer-based learning seems the most cost-effective and efficient strategy, when considering caregivers’ characteristics, the clinical field, and educational interventions across the pre-, peri-, and post-implementation processes.
Predicting the Chemical Attributes of Fresh Citrus Fruits Using Artificial Neural Network and Linear Regression Models
Authors: Al-Saif Adel M. , Abdel-Sattar Mahmoud , Eshra Dalia H. , Sas-Paszt Lidia , Mattar Mohamed A.
Published: November 2022

Different chemical attributes, measured via total soluble solids (TSS), acidity, vitamin C (VitC), total sugars (Tsugar), and reducing sugars (Rsugar), were determined for three groups of citrus fruits (i.e., orange, mandarin, and acid); each group contains two cultivars. Artificial neural network (ANN) and multiple linear regression (MLR) models were developed for TSS, acidity, VitC, Tsugar, and Rsugar from fresh citrus fruits by applying different independent variables, namely the dimensions of the fruits (length (FL) and diameter (FD)), fruit weight (FW), yield/tree, and soil electrical conductivity (EC). The results of ANN application showed that a feed-forward back-propagation network type with four input neurons (Yield/tree, FW, FL, and FD) and eight neurons in one hidden layer provided successful modeling efficiencies for TSS, acidity, VitC, Tsugar, and Rsugar. The effect of the EC variable was not significant. The hyperbolic tangent of both the hidden layer and the output layer of the developed ANN model was chosen as the activation function. Based on statistical criteria, the ANN developed in this study performed better than the MLR model in predicting the chemical attributes of fresh citrus fruits. The root mean square error of TSS, acidity, VitC, Tsugar, and Rsugar ranged from 0.064 to 0.453 and 0.068 to 0.634, respectively, for the ANN model, and 0.568 to 4.768 and 0.550 to 4.830, respectively, for the MLR model using training and testing datasets. In addition, the relative errors obtained through the ANN approach provided high model predictability and feasibility. In chemical attribute modeling, the FD and FL variables exhibited high contribution ratios, resulting in a reliable predictive model. The developed ANN model generally showed a good level of accuracy when estimating the chemical attributes of fresh citrus fruit.
Himalayan Horticulture Produce Supply Chain Disruptions and Sustainable Business Solution—A Case Study on Kiwi Fruit in Uttarakhand
Authors: Sharma Kushika , Kumar Rupesh , Kumar Amit
Published: November 2022

Uttarakhand, a state in the northern region of India which is traversed by the Himalayas, grows a variety of horticultural crops (e.g., fruits, vegetables, spices, and flowers) and is experienced with large-scale horticulture production at the national and/or international levels. Due to the wide variation in the climatic conditions and growing patterns, its pattern varies from harvest to harvest and from one province to another in terms of range, production, and yield. One of the most lucrative industries in Uttarakhand’s hilly areas is horticultural cultivation. It substitutes for the neighborhood economy and helps farmers make a living. According to the literature, no work on the supply chain management of fruits in the hilly areas of Uttarakhand has yet been documented to analyze the growth of horticulture cultivation. Thus, the primary objective of this paper is to focus on the supply chain management of kiwi fruit, a type of major growing fruit in Uttarakhand’s Bageshwar area. Additionally, this paper will offer a business plan for small-scale farmers to boost employment, economic development, and benefits. This study contributes to the discussion of the problems with the Himalayan fruit supply chain that is specific to the kiwi fruit and how a sustainable business model like horti-tourism can enable greater revenue generation for farmers while also resolving the problems with the Himalayan produce supply chain.
Overexpression of the SiLEA5 Gene in Saussurea involucrata Increases the Low-Temperature Tolerance of Transgenic Tomatoes
Authors: Liu Xiaoyan , Xia Wenwen , Zhang Xiaoli , Li Aowei , Qin Jiawang , Sun Huili , Li Jin , Zhu Jianbo
Published: November 2022

The late embryonic development abundant protein (LEA) is a family of proteins widely present in the body and related to osmoregulation. Saussurea involucrata is an extremely cold-tolerant plant. In our previous studies, we found that the LEAs gene in Saussurea involucrata has up-regulated expression under low temperature. To evaluate the biological function of SiLEA5 protein under low-temperature stress and its potential in agricultural breeding, we isolated the SiLEA5 gene from Saussurea involucrata, constructed a plant overexpression vector, and transformed tomato. We found that SiLEA5 protein significantly increased the yield of transgenic tomatoes by increasing their photosynthetic capacity, including net photosynthetic rate, stomatal conductance, and intercellular CO2 concentration. Under low-temperature stress, the SiLEA5 protein can regulate proline metabolism and oxidative stress, which confers transgenic tomatos with cold resistance. Thus, our work provided evidence for the role of SiLEA5 protein in low-temperature stress resistance in plants, as well as potential applications in crop breeding and cold stress resistance research.
Rapid In Vitro Propagation of Fig (Ficus carica L.) ‘Violette de Solliès’ Supported by Molecular and Microscopy Analyses
Authors: Ling Wan Ting , Tan Li Vern , Khor Soo Ping , Sriskanda Dahmendra , Subramaniam Sreeramanan , Chew Bee Lynn
Published: November 2022

Ficus carica L. is a common fig that is an incredibly nutritional fruit, well-known for its medicinal and economic values. This study aims to establish an efficient protocol for the mass propagation of fig plantlets (Ficus carica L.) for the cultivar ‘Violette de Solliès’. Surface-sterilized shoot-tip explants were cultured on Murashige and Skoog (MS) medium supplemented with different concentrations of cytokinins (6-benzylaminopurine, BAP; thidiazuron, TDZ; kinetin, Kn; and zeatin, Zea). Induced shoots were rooted on Woody Plant Medium (WPM) with different concentrations of auxins (naphthalene-acetic acid, NAA; indole-3-acetic acid, IAA; and indole-3-butyric acid, IBA). Rooted explants were acclimatized in eight different soil substrates prior to cultivation in a commercial plot. The propagated plantlets were analyzed for genetic stability and clonal fidelity using RAPD and SCoT molecular markers, whereas scanning electron microscopy (SEM) was performed to observe the stomata morphology of post-acclimatized plants. MS media supplemented with 5.0 mg/L BAP was the optimal treatment for multiple shoot induction (15.20 ± 1.03 shoots), whereas the highest percentage of rooting (93.33%) was achieved in WPM supplemented with 3.0 mg/L IBA. Plantlets were successfully acclimatized in biochar soil with a survival rate of 100%. RAPD and SCoT analysis showed no polymorphism occurrences across six subculture cycles, whereas observations via SEM indicated normal stomata structures on the leaves of acclimatized plantlets. This study documents an efficient micropropagation protocol for Ficus carica cv. ‘Violette de Solliès’ for the production of uniformed and true-to-type plant stocks suitable for commercial propagation.
Antioxidant and Anti-Inflammatory Potential of Seaweed Extracts as Functional Ingredients
Authors: Amaro Helena M. , Pagels Fernando , Tavares Tânia G. , Costa Isabel , Sousa-Pinto Isabel , Guedes A. Catarina
Published: November 2022

The use of seaweed as a source of bioactive extracts has received increased attention from the market in recent years—particularly for nutraceutical applications. In this context, this study evaluated the nutraceutical application of seaweed biomass and extracts from three seaweeds from Portugal: Ulva sp., Laminaria ochroleuca, and Chondrus crispus. For each of the said seaweeds, four different extracts were obtained using GRAS solvents—acetone (A), ethanol (E), ethanol–water (1:1) (EW), and one polysaccharide-rich extract (P) using water and further precipitation with ethanol. The bioactive potential of the extracts was assessed in terms of antioxidant capacity (ABTS•+, DPPH•, •NO, O2•− scavenging, and ORAC-FL assay) and anti-inflammatory capacity (COX inhibition and human red blood cell membrane stabilisation). Furthermore, the biochemical profile was determined for the raw biomass and extracts to better comprehend their possible applications as nutraceuticals. The results show that all extracts have antioxidant potential. Five extracts (L. ochroleuca E, EW, and P and Ulva sp. E and P) showed anti-inflammatory capacity. Overall, L. ochroleuca EW extract exhibited the most promising potential as both an antioxidant and anti-inflammatory and is an interesting candidate nutraceutical ingredient.
Identifying Modelling Issues through the Use of an Open Real-World Flood Dataset
Authors: Bellos Vasilis , Kourtis Ioannis , Raptaki Eirini , Handrinos Spyros , Kalogiros John , Sibetheros Ioannis A. , Tsihrintzis Vassilios A.
Published: November 2022

The present work deals with the reconstruction of the flood wave that hit Mandra town (Athens, Greece) on 15 November 2017, using the framework of forensic hydrology. The flash flood event was caused by a huge storm event with a high level of spatial and temporal variability, which was part of the Medicane Numa-Zenon. The reconstruction included: (a) the post-event collection of 44 maximum water depth traces in the town; and (b) the hydrodynamic simulation employing the HEC-RAS and MIKE FLOOD software. The derived open dataset (which also includes additional data required for hydrodynamic modeling) is shared with the community for possible use as a benchmark case for flood model developers. With regards to the modeling issues, we investigate the calibration strategies in computationally demanding cases, and test whether the calibrated parameters can be blindly transferred to another simulator (informed modeling). Regarding the calibration, it seems that the coupling of an initial screening phase with a simple grid-search algorithm is efficient. On the other hand, the informed modeling concept does not work for our study area: every numerical model has its own dynamics while the parameters are of grey-box nature. As a result, the modeler should always be skeptical about their global use.
The Impact of the Pandemic on Mental Health in Ethnically Diverse Mothers: Findings from the Born in Bradford, Tower Hamlets and Newham COVID-19 Research Programmes
Authors: McIvor Claire , Vafai Yassaman , Kelly Brian , O’Toole Sarah E. , Heys Michelle , Badrick Ellena , Iqbal Halima , Pickett Kate E. , Cameron Claire , Dickerson Josie
Published: November 2022

Restrictions implemented by the UK Government during the COVID-19 pandemic have served to worsen mental health outcomes, particularly amongst younger adults, women, those living with chronic health conditions, and parents of young children. Studies looking at the impact for ethnic minorities have reported inconsistent findings. This paper describes the mental health experiences of mothers from a large and highly ethnically diverse population during the pandemic, using secondary analysis of existing data from three COVID-19 research studies completed in Bradford and London (Tower Hamlets and Newham). A total of 2807 mothers participated in this study with 44% White British, 23% Asian/Asian British Pakistani, 8% Other White and 7% Asian/Asian British Bangladeshi backgrounds. We found that 28% of mothers experienced clinically important depressive symptoms and 21% anxiety symptoms during the pandemic. In unadjusted analyses, mothers from White Other, and Asian/Asian British Bangladeshi backgrounds had higher odds of experiencing symptoms, whilst mothers from Asian/Asian British Indian backgrounds were the least likely to experience symptoms. Once loneliness, social support and financial insecurity were controlled for, there were no statistically significant differences in depression and anxiety by ethnicity. Mental health problems experienced during the pandemic may have longer term consequences for public health. Policy and decision makers must have an understanding of the high risk of financial insecurity, loneliness and a lack of social support on mother’s mental health, and also recognise that some ethnic groups are far more likely to experience these issues and are, therefore, more vulnerable to poor mental health as a consequence.
The German COVID-19 Digital Contact Tracing App: A Socioeconomic Evaluation
Authors: Ellmann Stephan , Maryschok Markus , Schöffski Oliver , Emmert Martin
Published: November 2022

The COVID-19 pandemic posed challenges to governments in terms of contact tracing. Like many other countries, Germany introduced a mobile-phone-based digital contact tracing solution (“Corona Warn App”; CWA) in June 2020. At the time of its release, however, it was hard to assess how effective such a solution would be, and a political and societal debate arose regarding its efficiency, also in light of its high costs. This study aimed to analyze the effectiveness of the CWA, considering prevented infections, hospitalizations, intensive care treatments, and deaths. In addition, its efficiency was to be assessed from a monetary point of view, and factors with a significant influence on the effectiveness and efficiency of the CWA were to be determined. Mathematical and statistical modeling was used to calculate infection cases prevented by the CWA, along with the numbers of prevented complications (hospitalizations, intensive care treatments, deaths) using publicly available CWA download numbers and incidences over time. The monetized benefits of these prevented cases were quantified and offset against the costs incurred. Sensitivity analysis was used to identify factors critically influencing these parameters. Between June 2020 and April 2022, the CWA prevented 1.41 million infections, 17,200 hospitalizations, 4600 intensive care treatments, and 7200 deaths. After offsetting costs and benefits, the CWA had a net present value of EUR 765 m in April 2022. Both the effectiveness and efficiency of the CWA are decisively and disproportionately positively influenced by the highest possible adoption rate among the population and a high rate of positive infection test results shared via the CWA.
Association of Self-Reported Depression Symptoms with Physical Activity Levels in Czechia
Authors: Maranhao Neto Geraldo A. , Lattari Eduardo , Oliveira Bruno Ribeiro Ramalho , Polcrova Anna Bartoskova , Infante-Garcia Maria M. , Kunzova Sarka , Stokin Gorazd B. , Gonzalez-Rivas Juan P.
Published: November 2022

Worldwide, depressive disorder is one of the leading determinants of disability-adjusted life years. Although there are benefits associated with a higher physical activity (PA) level, there is a lack of information related to this relationship, especially in countries such as Czechia, where modern approaches to mental health care only recently emerged. The present study aimed to evaluate the association between the level of depression and different PA levels following the World Health Organization (WHO) PA guidelines and according to specific symptoms that indicate depression. Multivariable-adjusted Poisson regression models were used to calculate the prevalence rate (PR) in a sample of 2123 participants (45.3% men, median 48 years). Compared to subjects with insufficient PA, moderate and high PA levels were inversely associated with continuous depression scores (PR = 0.85; 95% CI: 0.75–0.97; and PR = 0.80; 95% CI: 0.70–0.92). Depressed mood and worthlessness were the symptoms associated with moderate and high PA. Tiredness, change in appetite, and concentration problems were related to high PA. The results suggest that reaching the minimum PA target according to the guidelines seems to be effective, and this could stimulate adherence. However, more specific improvements in symptomatology will require a subsequent gradual increase in PA levels.
Still Standing Inside: A Local Idiom Related to Trauma among Namibian Speakers of Khoekhoegowab
Authors: Claudius Milena , Shino Elizabeth N. , Job Sylvanus , Hofmann Daniel , Thalmayer Amber Gayle
Published: November 2022

Euro-centric psychiatric conceptualizations often ignore the interplay of local with universal factors in psychological suffering. Emic, locally focused perspectives can enrich etic knowledge to provide culturally sensitive care and to better elucidate the role of culture in mental illness. This study explored the idiom Tsûsa ǃNaeǃkhais xa hâǃnâ/mâǃnâ/ǂgâǃnâhe hâ (a terrible event has entered a person and remains standing inside), which was understood to relate to experiences of trauma and post-traumatic stress, among speakers of Khoekhoegowab, a southern-African click language. Semi-structured interviews were conducted with 16 participants from six urban and rural communities in Namibia. Questions probed perceptions of the idiom in terms of etiology, course, and risk and resilience factors from a socio-ecological framework. Five key themes were identified using thematic analysis: origin in a shocking event; intrusive recurrence of memories, “it keeps on coming back”; the close interplay between mental and physical suffering; the importance of active engagement in healing through prayer and acceptance; and the role of the community in both alleviating and amplifying distress. Our findings highlight local norms and strategies for adaptive coping, and the benefits of exploring local idioms to elucidate the braiding together of universal and cultural elements in psychological distress.
Computer-Assisted Annotation of Digital H&E/SOX10 Dual Stains Generates High-Performing Convolutional Neural Network for Calculating Tumor Burden in H&E-Stained Cutaneous Melanoma
Authors: Nielsen Patricia Switten , Georgsen Jeanette Baehr , Vinding Mads Sloth , Østergaard Lasse Riis , Steiniche Torben
Published: November 2022

Deep learning for the analysis of H&E stains requires a large annotated training set. This may form a labor-intensive task involving highly skilled pathologists. We aimed to optimize and evaluate computer-assisted annotation based on digital dual stains of the same tissue section. H&E stains of primary and metastatic melanoma (N = 77) were digitized, re-stained with SOX10, and re-scanned. Because images were aligned, annotations of SOX10 image analysis were directly transferred to H&E stains of the training set. Based on 1,221,367 annotated nuclei, a convolutional neural network for calculating tumor burden (CNNTB) was developed. For primary melanomas, precision of annotation was 100% (95%CI, 99% to 100%) for tumor cells and 99% (95%CI, 98% to 100%) for normal cells. Due to low or missing tumor-cell SOX10 positivity, precision for normal cells was markedly reduced in lymph-node and organ metastases compared with primary melanomas (p < 0.001). Compared with stereological counts within skin lesions, mean difference in tumor burden was 6% (95%CI, −1% to 13%, p = 0.10) for CNNTB and 16% (95%CI, 4% to 28%, p = 0.02) for pathologists. Conclusively, the technique produced a large annotated H&E training set with high quality within a reasonable timeframe for primary melanomas and subcutaneous metastases. For these lesion types, the training set generated a high-performing CNNTB, which was superior to the routine assessments of pathologists.
Effects of Integrative Cognitive Function Improvement Program on Cognitive Function, Oral Health, and Mental Health in Older People: A Randomized Clinical Trial
Authors: Jung Eun-Seo , Choi Yoon-Young , Lee Kyeong-Hee
Published: November 2022

We aimed to investigate the effects of an integrative cognitive function improvement program that combined existing cognitive, emotional, and physical therapies on cognitive function, oral health, and mental health in elder participants. Participants were classified into one of the following groups: cognitively normal (CN; n = 18), mild cognitive impairment (MCI; n = 17), and control (n = 17). An integrative cognitive function improvement program was administered to the CN and MCI groups for six weeks. To measure cognitive function, electroencephalogram (EEG) and cerebral blood flow (CBF) were evaluated, and to measure oral health, the O’Leary index, Löe & Silness index, tongue coating, unstimulated saliva flow rate, and oral muscle strength were measured. To measure mental health status, mental health, happiness and social support were measured. The CN and MCI groups showed a significant change in EEG-based indices for awareness level and physical stress. Regarding oral health, the O’Leary and the Löe & Silness index score decreased significantly in the CN and MCI groups. Saliva flow rate increased significantly in the CN and MCI groups. In regards to mental health, the happiness score increased post-intervention in the CN and MCI groups. In conclusion, the integrative cognitive function improvement program was effective in improving cognitive function, oral health, and mental health of elder people.
Safety Climate Evaluation in Primary Health Care: A Cross-Sectional Study
Authors: Ferreira Marlene Manuela Moreira , Teixeira Andreia Sofia Costa , Taveira-Gomes Tiago Salgado de Magalhães
Published: November 2022

The perception of the existence of deficits in patient safety, the associated costs and the limitation of resources have made it essential to define improvement strategies. Important concepts have emerged, such as safety climate, which evaluates the perceptions of safety status held by professionals in relation to their organization. The aim of this study is to characterize the safety climate in primary health care (PHC) using the Safety Attitudes Questionnaire (SAQ)—Short Form 2006 PT and to assess associations between SAQ-Short Form 2006 PT scores and demographic and professional characteristics. A cross-sectional study was conducted in all public PHC units in the northern region of Portugal. Data were collected through an online questionnaire shared via institutional emails and by means of a snowball approach. Descriptive and inferential statistical analysis were performed. Statistical significance set at p ≤ 0.05. A total of 649/7427 (8.7%) responses were included in the analyses. The mean and median total SAQ-Short Form 2006 PT scores were 69.23 (SD = 15.73, range 22.22–100.00) and 71.53 [59.03; 79.86], respectively. This is the first study to assess the safety climate in PHC in Portugal. The median obtained total SAQ-Short Form 2006 PT score was 71.53 [59.03; 79.86], which is below the threshold of ≥75, indicating safety deficits.
Proposal of Combined Noise and Hand-Arm Vibration Index for Occupational Exposure: Application to a Study Case in the Olive Sector
Authors: Nieto-Álvarez Raquel , de la Hoz-Torres María L. , Aguilar Antonio J. , Martínez-Aires María Dolores , Ruiz Diego P.
Published: November 2022

In many production and industrial sectors, workers are exposed to noise and hand-arm vibrations (HAV). European directives have established the maximum limit values or exposure action values for noise and vibration independently. However, in many cases, workers who endure hand-arm vibration also receive high noise levels. This research suggests a procedure to aid the establishment of precautionary measures for workers with simultaneous exposure to both physical agents. This procedure defines a combined index based on the energy doses for both noise and HAV. From this combined index, the suggested methodology allows a recommended exposure time for workers with simultaneous noise and HAV exposure to be calculated. This methodology can be adapted to tackle the relative importance assigned to both agents according to the safety manager and new knowledge on combined health effects. To test this method, a measurement campaign under real working conditions was conducted with workers from the olive fruit-harvesting sector, where a variety of hand-held machinery is used. The results of the study case show that the suggested procedure can obtain reliable exposure time recommendations for simultaneous noise and HAV exposures and is therefore a useful tool for establishing prevention measures.
Effects of Low-Impact Development Facilities (Water Systems of the Park) on Stormwater Runoff in Shallow Mountainous Areas Based on Dual-Model (SWMM and MIKE21) Simulations
Authors: Lai Yue , Lu Yiyun , Ding Tingting , Sun Huiyi , Li Xuanying , Ge Xiaoyu
Published: November 2022

Rapid urbanization has triggered more serious urban flood risks. Many studies have focused on intra-urban flooding, but less attention has been paid to rainfall and flood risks at the urban fringe. Nowadays, China is vigorously promoting the construction of sponge cities in the whole area. It is important to study the construction of sponge cities in shallow mountainous areas, which are an important barrier between cities and mountains. The purpose of this paper is to investigate the performance of Low-Impact Development (LID) facilities under different rainfall scenarios in developed shallow mountainous areas. The second garden and flower exposition (“the Expo Park”) in Hebei Province is used as an example. The SWMM and MIKE21 models were used to simulate the hydrological processes before and after the construction of “the Expo Park”, and the models were calibrated with the measured data. Peak flow rate, outflow volume, rainfall-outflow ratio, runoff velocity, and water feature area of the water system were used as indicators to evaluate their effectiveness. The results showed that the placement of LID facilities had a positive impact on the construction of the shallow mountain area. Specifically, (1) LID facilities can reduce the peak flow rate, delayed peak flow time, outflow volume, and rainfall outflow ratio of stormwater runoff in mountainous areas; and (2) they can effectively collect rainwater and become a supplement to the landscape water system of the site. These findings provide a scientific basis for the construction of LID facilities in shallow mountainous areas, which is important for the development and flood management of shallow mountainous areas.
Slack Resources, Corporate Performance, and COVID-19 Pandemic: Evidence from China
Authors: Jin Ling , Choi Jun Hyeok , Kim Saerona , Cho Kwanghee
Published: November 2022

COVID-19 has caused tremendous damage to global economies, and similar health crises are expected to happen again. This study tests whether slack resources would enable companies to prepare for such uncertainties. Specifically, we explored the influence of the COVID-19 patient occurrence on corporate financial performance and the buffering effect of financial slacks using Chinese listed companies’ data during 2021. We also examined whether this effect differs across firms’ financial health and industry. Test results are as follows. First, consistent with the recent studies on pandemics, the degree of COVID-19 prevalence had a negative impact on the Chinese company’s financial performance, and slack resources offset this adverse effect. Second, slack’s buffering effects appeared mostly in financially constrained companies. Third, such effects mostly appeared in industries vulnerable to the COVID-19 shock. In the business environment of 2021, adapted to COVID-19, our main test result seems to mainly come from companies with a greater need for slack. Our tests imply that, despite differences in the degree of accessibility to resources, excess resources help companies overcome the COVID-19 crisis, which means that firms can more efficiently respond to economic shocks such as COVID-19 if they reserve past profits as free resources. This study contributes to the literature in that there is limited research on the slack resources’ buffering effect on the COVID-19 shock and that this study works as a robustness test as it uses data from one of the East Asian regions at a time when the control of COVID-19 was relatively consistent and successful, which can limit the effect of COVID-19 and slacks.