bluuebunny/crossref_metadata_2025 huggingface dataset:
Mutation of the conserved late element in geminivirus CP promoters abolishes Arabidopsis TCP24 transcription factor binding and decreases H3K27me3 levels on viral chromatin
Authors: Williams Jacqueline , Regedanz Elizabeth , Lucinda Natalia , Nava Fereira Alba Ruth , Lacatus Gabriela , Berger Mary , O’Connell Nels , Coursey Tami , Ruan Jianhua , Bisaro David M. , Sunter Garry
Published: July 2024

In geminiviruses belonging to the genus Begomovirus, coat protein (CP) expression depends on viral AL2 protein, which derepresses and activates the CP promoter through sequence elements that lie within the viral intergenic region (IR). However, AL2 does not exhibit sequence-specific DNA binding activity but is instead directed to responsive promoters through interactions with host factors, most likely transcriptional activators and/or repressors. In this study, we describe a repressive plant-specific transcription factor, Arabidopsis thaliana TCP24 (AtTCP24), that interacts with AL2 and recognizes a class II TCP binding site in the CP promoter (GTGGTCCC). This motif corresponds to the previously identified conserved late element (CLE). We also report that histone 3 lysine 27 trimethylation (H3K27me3), an epigenetic mark associated with facultative repression, is enriched over the viral IR. H3K27me3 is deposited by Polycomb Repressive Complex 2 (PRC2), a critical regulator of gene expression and development in plants and animals. Remarkably, mutation of the TCP24 binding site (the CLE) in tomato golden mosaic virus (TGMV) and cabbage leaf curl virus (CaLCuV) CP promoters greatly diminishes H3K27me3 levels on viral chromatin and causes a dramatic delay and attenuation of disease symptoms in infected Arabidopsis and Nicotiana benthamiana plants. Symptom remission is accompanied by decreased viral DNA levels in systemically infected tissue. Nevertheless, in transient replication assays CLE mutation delays but does not limit the accumulation of viral double-stranded DNA, although single-stranded DNA and CP mRNA levels are decreased. These findings suggest that TCP24 binding to the CLE leads to CP promoter repression and H3K27me3 deposition, while TCP24-AL2 interaction may recruit AL2 to derepress and activate the promoter. Thus, a repressive host transcription factor may be repurposed to target a viral factor essential for promoter activity. The presence of the CLE in many begomoviruses suggests a common scheme for late promoter regulation.
The power of virtual reality performance experiences for education
Authors: Kirwan Emily
Published: July 2024

This article looks at how empathy and experience, existing within the virtual reality (VR) performance medium, facilitate learning. The article focuses on the importance of soft skills in education and highlights empathy and experience as important contributors to developing skills in understanding and communicating with others. It acknowledges that the development of skills and attributes that benefit education and employment also benefit life satisfaction and well-being. The article contemplates VR as an ‘empathy machine’ and explores how VR performances offer immersive and interactive storytelling experiences. It argues that VR could promote empathy by broadening perspectives through exposure to immersive storytelling, in addition to real-world interactions, helping to advance beneficial soft skills development. If VR could be an effective ‘empathy machine’, then VR performances could offer an even more powerful medium to develop soft skills and empathy. The article draws on three different examples of VR performances to illustrate their education potency and concludes that, with further research, VR performances could be influential tools in education for soft skill development.
WALKING ON TRANSITION: PERAN PERCEIVED SOCIAL SUPPORT (FRIEND) SEBAGAI MODERATOR PADA PSYCHOLOGICAL WELL BEING TERHADAP PENYESUAIAN DIRI MAHASISWA BARU
Authors: Dara Yuliezar Perwira , Harmanto Prezilia Ramadhanti , Asmarani Dea Resta Cicilia , Rahma Ulifa , Faizah Faizah
Published: July 2024

Penyesuaian diri atau adjustment bagi mahasiswa diperlukan dalam berbagai setting kehidupan, baik secara akademis maupun non akademis. Kemampuan mereka dalam beradapatasi sangat bervariasi tergantung pada latar belakang, pengalaman, lingkungan sekolah sebelumnya, dan lingkungan perguruan tinggi saat ini. Adjustment adalah proses untuk mengenali dan mengadopsi cara-cara berperilaku yang sesuai, baik secara sosial maupun emosi. Penelitian ini bertujuan untuk mengetahui peran perceived social support (friend) sebagai variabel moderator penting dari korelasi antara psychological well-being dan penyesuaian mahasiswa baru di perguruan tinggi. Metode yang digunakan dalam penelitian ini yaitu menggunakan metode penelitian kuantitatif dengan karakteristik subjek yaitu mahasiswa baru  aktif di perguruan tinggi, dengan jumlah subjek sebanyak 751 subyek, terdiri dari 205 mahasiswa dan 546 mahasiswi. Teknik yang digunakan dalam pengambilan sampel yaitu menggunakan teknik accidental sampling. Pengumpulan data menggunakan tiga skala yaitu 1) Multidimensional Scale of Perceived Social Support (MSPSS) (α=.85), 2) Ryff’s Scale of Psychological well-being dan 3) Inventory of New College Student Adjustment (INCA): dimensi supportive network (α=.83) dan belief in self (α=.77). Teknik Moderated Regression Analysis (MRA) digunakan untuk melakukan pengujian hipotesis dalam penelitian ini. Berdasarkan hasil pengujian hipotesis, diperoleh hasil bahwa keberadaan perceived social support (friends) sebagai variabel moderator dapat memperkuat peran antara variabel psychological well-being terhadap penyesuaian mahasiswa baru, dengan nilai signifikansi .000 (p<.05). Besar peran variabel moderator adalah 24.1%.
KONSTRUKSI ALAT UKUR HOMESICKNESS PADA MAHASISWA RANTAU
Authors: Sinantia Vemita , Nariswari Anindia Tri , Ramadhani Istiqomah Dwi , Alghifari Muhammad Musa , Tjarliman Khansa Anindyaputri , Qisthi Yasmine Kayla
Published: July 2024

Masa transisi memasuki pendidikan tinggi menuntut mahasiswa untuk mampu beradaptasi dengan lingkungan baru, yang terkadang menimbulkan tantangan baru bagi mahasiswa rantau karena tidak hanya menyesuaikan diri dengan kehidupan akademik di kampus tetapi juga kehidupan sosial di lingkungan baru. Tak jarang sebagian mahasiswa mengalami kerinduan akan rumah dan keluarga dekat atau yang biasa disebut homesickness. Artikel ini menyajikan konstruksi alat ukur homesickness yang disusun berdasarkan aspek keterikatan pada rumah dan kesulitan menyesuaikan diri yang diujicobakan pada 97 mahasiswa rantau tahun pertama. Serangkaian uji psikometri berupa uji validitas, uji reliabilitas, dan uji daya beda dilakukan untuk memvalidasi skala homesickness hingga diperoleh nilai α Cronbach sebesar .921. pada putaran pertama, sebanyak 3 pernyataan tidak memenuhi kriteria indeks daya beda, dan di akhir diperoleh 29 pernyataan yang memenuhi kriteria. Penyempurnaan alat ukur diperlukan untuk pengembangan penelitian mendatang.
HUBUNGAN ANTARA CUSTOMER ENGAGEMENT DENGAN KEPERCAYAAN MEREK FASHION DARI UKM PADA MAHASISWA PSIKOLOGI UNIVERSITAS DIPONEGORO SEMARANG
Authors: Mujiasih Endah
Published: July 2024

Usaha Kecil dan Menengah (UKM) menjadi salah satu unit usaha di masyarakat yang berperan penting dalam perekonomian di Indonesia. Sayangnya, sampai saat ini produk UKM belum banyak dilirik oleh masyarakat karena kurangnya pengetahuan pemilik UKM tentang pentingnya pemasaran. Maka dari itu, produk-produk milik UKM membutuhkan berbagai aktivitas pemasaran agar lebih dekat secara psikologis, sehingga UKM dapat memperoleh kepercayaan masyarakat. Penelitian ini dilakukan untuk mengetahui hubungan antara customer engagement dengan kepercayaan merek produk fashion UKM pada mahasiswa Fakultas Psikologi Universitas Diponegoro. Penelitian ini melibatkan sebanyak 141 mahasiswa dengan teknik incidental random sampling. Instrumen yang digunakan dalam penelitian ini adalah skala customer engagement (29 aitem, α=.912) dan skala brand trust (37 aitem, α=.923). Hasil analisis regresi menunjukkan adanya hubungan yang positif dan signifikan antara customer engagement dengan brand trust pada mahasiswa. Customer engagement memberikan sumbangan efektif sebesar 37.6% pada brand trust.
STUDI FENOMENOLOGI TERHADAP PELECEHAN SEKSUAL SESAMA JENIS DI KAMPUS: REALITAS DAN PENGALAMAN LAKI-LAKI SEBAGAI KORBAN
Authors: Injany Evinsa , Hakim Atikah Kanza Atsarina , Lutfiputri Nadia Farah , Mahmud Zaki Khudzaifi , Hindarto Isni Hindriaty
Published: July 2024

Research on sexual harassment has gotten a lot of attention in the last three decades, partly because the victims are not solemnly women and children, men also have a chance to become one. Sexual harassment might occur in any setting, anywhere, at any moment, including at higher education institutions. The aim of this study is to examine how males interpret the experience of sexual harassment by same-sex perpetrators. This study further explores the understanding of experiences, and responses of five male students who encountered sexual harassment in a higher education setting, using qualitative methodology, a phenomenological approach, and data collection techniques in the form of interviews. The results of data collection indicate that the acts of sexual harassment experienced by the informants can be divided into direct (physical contact) or indirect. Then there is a connection between how males perceive their sexual harassment experience and the concept of masculinity. Furthermore, victims of samesex sexual harassment's reactions and interpretations of sexual harassment are influenced by their own experiences and self-perceptions.
Protective Effect of the Nitric Oxide Pathway in L-Citrulline Renal Ichaemia-Reperfusion Injury in Rats
Authors: Fu X. , Li S. , Jia G. , Gou L. , Tian X. , Sun L. , Ling X. , Lan N. , Yin X. , Ma R. , Liu Li , Liu Yi
Published: July 2024

To observe the protective effects of L-citrulline on the renal I/R injury and elucidate the mechanisms involved, 48 rats were randomized into eight groups: Group 1: sham operated; Group 2: I/R (45 min renal ischaemia and 24 h reperfusion); Group 3: I/R + L-citrulline (300 mg/kg, i.g.); Group 4: I/R + L-citrulline (600 mg/kg, i.g.); Group 5: I/R + L-citrulline (900 mg/kg, i.g.); Group 6: I/R + normal saline (NS, i.g.); Group 7: I/R + N sup ω nitro-L-arginine ester (L-NAME, 20 mg/kg, i.p.); Group 8: I/R + L-citrulline (900 mg/kg, i.g.) + L-NAME (20 mg/ kg, i.p.). At the end of the reperfusion period, serum was collected and the kidneys underwent histological and biochemical examinations. Our results showed that pre-treatment with L-citrulline (300, 600, and 900 mg/kg) significantly ameliorated the renal injury caused by I/R. Moreover, L-citrulline prevented induction of lipid peroxidation and increased the activity of superoxide dismutase and the levels of glutathione and nitric oxide. The I/R-induced decreases in total nitric oxide synthase activity, inducible nitric oxide activity, constitutive nitric oxide activity and endothelial nitric oxide protein expression in the renal cortex were significantly prevented. However, the L-citrulline-mediated protection was significantly antagonized by co-administration of L-NAME. These results suggested that L-citrulline administration exhibited significant protection against renal I/R injury. This protective effect, at least in part, via up-regulation of the endothelial nitric oxide protein expression and constitutive nitric oxide synthase activity, maintained production of nitric oxide at the basal level.
Świat jest w nas... Obrazy siebie i wewnętrznego świata w refleksjach początkujących nauczycielek
Authors: Barabasz Grażyna
Published: July 2024

The inspiration to create this text, and previously to conduct research among novice teachers (students of preschool and early school pedagogy) about their self-image and personal, inner world, are the words of my supervisor and educator, Professor Stanisław Dylak. The professor began his lectures on pedeutology for pedagogy students with the statement: “The world is within us.” For many, these words became an impulse to reflect on themselves, and for those more committed, also to reflect on their own identity as a teacher. They became a pretext for conversations with oneself, an answer to the question Who am I? What am I like? What kind of teacher do I want to be? These questions become even more important when we realize, referring to our own biographical experiences, that “The Teacher comes close to eternity. He can never tell where his influence ends” (Henry Brooks Adams). This text is an attempt to get to know the inner world of female pedagogy students who are planning to start working as teachers in the coming months or have just started it. The author designed and conducted qualitative research on a group of 12 beginning teachers – students of preschool and early school pedagogy, and in the presented text she presented the images of themselves and “their” world outlined by them. An interpretive approach was used to analyze the obtained data, which allowed for the presentation of a collective picture of the internal world of teachers at the beginning.
The construct of integrated group discussion (IGD) among undergraduate students: to what extent does group discussion performance reflect performance on IGD tasks?
Authors: Cheong Choo Mui , Xu Wandong , Pang Wanru , Zhu Siyu , Liao Xian
Published: July 2024

Integrated group discussion (IGD) tasks represent a new type of integrated speaking task that requires students to communicate with their peers after comprehending and using provided source materials. With its potential to enhance effective communication and information literacy, IGD stands at the core of language education. Although the IGD task type has become increasingly popular, its construct is still unexplored. In this study, 124 Hong Kong undergraduate students completed an IGD task and a group discussion (GD) task (i.e., without source materials) in Putonghua. Four factors, speech and expression, content with source use, interaction, and language usage, were extracted to represent IGD performance. Two indicators of GD performance (linguistic expression and engagement in interaction) significantly predicted IGD performance, explaining 21.9 % of its total variance. The large proportion of unexplained IGD performance variance suggests that IGD tasks may be worth implementing. The theoretical and practical implications of the findings are discussed in details.
Listenership always matters: active listening ability in L2 business English paired speaking tasks
Authors: Gao Wei , Wang Menghan
Published: July 2024

Active listening, foundational for meaningful social interaction, plays a pivotal role in enhancing interactional competence (IC) during dialogues. Despite its importance, current second language (L2) assessments, such as the TOEFL iBT and the Business English Certificate (BEC) Preliminary, notably does not include active listening in their evaluation metrics. The research presented here contributes significantly to this discourse by foregrounding the imperative of listener responses (LRs) in L2 communication and the diverse interactional functions they serve across different cultures. Notably, variations emerge, with Chinese speakers exhibiting more restrained verbal feedback compared to the more vocally expressive English counterparts. This study stands apart by underscoring the necessity of updating current L2 assessment rubrics, which currently prioritize grammatical proficiency, pronunciation, and vocabulary. By weaving in active listening, assessments can become more holistic, capturing more comprehensively a learner’s L2 interactional ability. Through rigorous quantitative and qualitative methodologies, this investigation probes the influence of active listening on BEC speaking test outcomes. Its findings are poised to revolutionize assessment strategies, urging a more encompassing approach that factors in both verbal and non-verbal cues, thereby reflecting genuine linguistic and interactional competence.
The Nature of Her Business
Authors: Kaidantzis Janet
Published: July 2024

Josephine Foster was doing her very best to feminize the wilderness. Sprinkling feminine imagery throughout her 1905 article for a women’s publication, she described the natural beauty of Glen Alpine Springs and encouraged her readers to discover for themselves the vacation pleasures of tramping in the mountains above Lake Tahoe, California.

While Foster coaxed women into the wilds, another woman worked to keep them comfortable there. Throughout that summer, Foster hiked, climbed, and got tired, but at the end of the day, a warm bed and a hot meal awaited her because Katherine Chandler was back managing Glen Alpine Springs resort and taking good care of her guests.

While women vacationing in the outdoors found freedom, female resort proprietors found opportunity. At a time when women faced limited choices in work outside the home, Katherine Chandler and other female resort proprietors found ways to turn traditional expectations of femininity to their advantage as businesswomen and outdoor enthusiasts. A collection of twenty unpublished letters written by Katherine Chandler, manager of Glen Alpine Springs to the resort’s owner, Susan Gilmore Pierce, forms the basis of this research. This essay knits together several strands in the historiographies of women in business, and women in the outdoors during the late Victorian and Progressive eras while contributing to the history of early tourism at Lake Tahoe.
Zinebi, año uno
Authors: Aguilar Alvear Santiago
Published: July 2024

Pasadas más de seis décadas desde su creación y con una trayectoria consolidada entre los festivales internacionales dedicados al documental, remontarse a los orígenes de Zinebi constituye casi una obligación para comprender la evolución del certamen en el marco de las tensiones creadas en la política cultural del franquismo. El análisis de la programación de la primera edición, a la luz de la doctrina hispanista que inspiró la creación del Instituto Vascongado de Cultura Hispánica, nos permitirá comprobar cómo, en la configuración del certamen fueron determinantes los criterios políticos y diplomáticos antes que los cinematográficos.
The Summer Seminar of Vilnius Symposium in the Faculty of History
Authors: Švedas Aurimas , Ivanauskas Vilius
Published: July 2024

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Activities and significance of the bilateral Lithuanian - Polish History Teaching Commission
Authors: Kasperavičius Algis Povilas
Published: July 2024

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Lithuanian School of Photography in the Context of Soviet Ideology About the Doctoral Dissertation ("The sovietization of expression and dissemination of Lithuanian photography" by Margarita Matulytė)
Authors: Drėmaitė Marija
Published: July 2024

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The use of the Ruthenian Languague in Ecclesiastical Books and its Relations to the Religious Identities in the Ruthenian Lands of the Grand Duchy of Lithuania in the 14 - 18th Centuries: the Protestant and Uniat Traditions
Authors: Temčinas Sergejus
Published: July 2024

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THE MYTHOLOGEME OF THTHE MOUNTAIN IN THE ALTAIC TEXTS OF RUSSIAN LITERATURE
Authors: Bogumil Tatiana
Published: July 2024

The article provides an overview of scientific sources regarding mountain literature related to the Russian Altai. Descriptions of alpine land- scapes written by travelers of the 19th century included realities of the area, analogies with foreign geographical objects (the Swiss Alps, the Lebanese Range, the Caucasus), with a different kind of artistic discourse, i.e., painting, with a different type of world order, i.e., terra incognita. In 19th century journalism the motif of spiritual transformation and miracle appeared (Altai = Athos), turning out to be especially in demand in Orthodox literature at the turn of the 20th century. Soviet literature desacralized the Altai cult of the mountains and the Master of Altai, previously represented mainly in ethnographic literature. Since the 1960s, there has been a growing trend of neo-mythologization of the Altai mountains. The paper reveals the semantics of the mountain mythologem in the context of the Altaic text of Russian culture on the example of V. N. Tokmakov’s novel “Dance of the Little Kings.” The neo-romantic world of the work is divided into two realities: fictitious (the capital) and real (Altai as an earthly projection of the otherworldly White Mountain). The significance of the Mountain in the novel is built on universal mythological motifs associ- ated with this mythologem (the locus of the battle between Good and Evil, the global flood, hidden treasures, a labyrinth-cave as an anti-mountain, initiation, an analogy with a tree, a man, a book, etc.). The author managed to create an original image of the mountain using a unique combination of these motifs, their historical-geographical and fantastical content.
Multigram synthesis of β-fluorinated saturated heterocyclic methanamines
Authors: Semeno Volodymyr V. , Melnykov Kostiantyn P.
Published: July 2024

An efficient multigram synthesis of β-fluorinated saturated heterocyclic methanamines - promising building blocks for drug discovery, starting from the corresponding saturated heterocyclic ketones is described. The method includes Wittig olefination, bromofluorination, nucleophilic substitution with azide, and Staudinger reaction and works well for four- to seven-membered nitrogen- and oxygen-containing heterocyclic derivatives
Rhodanine-based 4-(furan-2-yl)benzoic acids as inhibitors of xanthine oxidase
Authors: Beiko Alona V. , Kobzar Oleksandr L. , Kachaeva Maryna V. , Pilyo Stepan G. , Kozachenko Olexandr P. , Vovk Andriy I.
Published: July 2024

A series of rhodanine derivatives bearing 4-(furan-2-yl)benzoic acid moiety were synthesized and studied as inhibitors of xanthine oxidase. This enzyme is a known target for allopurinol and febuxostat used in the treatment of hyperuricemia, gout, and other diseases. The synthesized compounds with different substituents in position 3 of the rhodanine ring showed in vitro inhibitory activities towards xanthine oxidase in a low micromolar concentration range. The 4-(furan-2-yl)benzoic acid derivative with a fragment of N-unsubstituted rhodanine was found to have the lowest IC50 value which does not depend on the presence of albumin or Tween-80 under the assay conditions. According to kinetic data, the rhodanine-based 4-(furan-2-yl)benzoic acid was a mixed-type inhibitor with the same affinity for the free enzyme and the enzyme-substrate complex. Molecular docking and molecular dynamic studies were performed to elucidate the binding mode of this compound in the active site of xanthine oxidase
Going Wild in Urban America
Authors: Bland Alastair
Published: July 2024

The author describes 10 weeks he spent eating only foraged and wild food during university days at the University of California, Santa Barbara.
Cooks, Culinary Ability and Convenience Foods
Authors: Short Frances
Published: July 2024

This is the pith of a doctoral thesis submitted to the Centre for Food Policy, Thames Valley University in 2003. It may be thought of as a contribution to that eternal dinner-party topic: ‘Why do we consume increasing amounts of cookery on television and the printed page while sales of ready-prepared meals spiral to unseen heights?’
Nawal Nasrallah: Delights from the Garden of Eden – A Cookbook and a History of the Iraqi Cuisine
Authors: Jaine Tom
Published: July 2024

Nawal Nasrallah: Delights from the Garden of Eden – A Cookbook and a History of the Iraqi Cuisine: 1st Books, 2003: ISBN 140334793X: 646pp., b&w photos, p/b. For more information about purchasing, call 1-888-280-7715 or visit www.1stbooks.com or www.iraqicookbook.com.
CONSTRUÇÃO DE CURRÍCULOS POR MEIO DE METODOLOGIAS ATIVAS
Authors: Deus Júnior Getúlio Antero de
Published: July 2024

Em tempos de incertezas, mudanças e desafios enfrentados pela Educação Superior, as estratégias de ensino docente podem contribuir para a implantação da aprendizagem ativa na sala de aula. Todavia, as metodologias ativas apresentam controle, monitoramento e avaliação de todo o processo de ensino-aprendizagem, ao passo que as estratégias do ensino docente, não necessariamente têm essa intenção. Sendo assim, as metodologias ativas de Aprendizagem Baseada em Problemas (ABP) e de Aprendizagem Baseada em Projetos (ABPj) são apresentadas de forma estruturada, como candidatas em potencial para uso na Educação Superior. Ademais, são apresentadas novas possibilidades para as estruturas que compõem um currículo, denominadas células curriculares, propostas a partir de quatro modelos: (a) célula curricular que utiliza apenas a metodologia ativa de ABP (modelo A); (b) célula curricular que utiliza apenas a metodologia ativa de ABPj (modelo B); (c) célula curricular híbrida que utiliza as metodologias ativas de ABP e de ABPj (modelo C); e (d) célula curricular híbrida que utiliza as metodologias ativas de ABP e de ABPj, e aulas expositivas dialogadas (modelo D). A partir de pequenas modificações nos modelos B e C das células, é apresentada uma proposta de estruturação do currículo para um Curso de Especialização Lato Sensu em Engenharia Intercultural. Os desafios na implantação das metodologias ativas são enormes, e a busca da inovação curricular não pode vir repentinamente ou radicalmente. De fato, é preciso diálogo, compreensão das práticas estabelecidas e construção de alicerce sólido, para que os envolvidos no processo compreendam a importância da verdadeira transformação.
Histone-Lysine N-Methyltransferase 2D (KMT2D) Impending Therapeutic Target for the Management of Cancer: The Giant Rats Tail
Authors: Jasmin Meshak Dhanashekaran Cecileya , Radhakrishnan Narayanaswamy , Prabhu Venugopal Vinod , Sakthivel Kunnathur Murugesan , Radha Rasmi Rajan
Published: July 2024

The histone-lysine N-methyltransferase 2D (KMT2D), tumor suppressor gene which is the major component of histone H3K4 mono-methyltransferase in mammals and has significant role in regulation of a gene which are frequently mutated that lead to many different types of cancers that include non-Hodgkin lymphoma, medulloblastoma, prostate carcinoma, renal carcinoma, bladder carcinoma and lung carcinoma. KMT2D gene epigenetic alterations in histone methylation play a significant role for the initiation and progression of cancers from pre-cancerous lesions, yet its complete function in oncogenesis remains unsolved. KMT2D deficiency - loss are thought of initial mediators of cancer development and cell migration such as B-cell lymphoma, medulloblastoma, melanoma, pancreas and lung cancer. The KMT2D loss has know to activate glycolytic genes that promote aggressive tumor progression. Therefore, the present review serves to underline the update on recent research pertaining to KMT2D gene, that could be a potential therapeutic target in downregulating glycolytic genes such as Pgk1, Ldha, Pgam1 and Gapdh; 2, epidermal growth factor receptor tyrosine kinase (EGFR-TK ) - ERBB2, RTK-RAS signaling, RAS activator genes Rgl1, Rasgrp1, Rasgrf1, Rasgrf 2 and Rapgef5 in suppressing the tumor progression that may represent novel targeted therapy for the management of cancer. This review will facilitate to understand the gene expression that inhibits cancer progression and which could serve as a potential molecular target in understanding cancer pathogenesis.
Az erdei szalonka (Scolopax rusticola L.) tavaszi vonulásának vizsgálata Erdélyben
Authors: Bende Attila , Csanády Viktória , Szász Botond , László Richárd
Published: July 2024

Investigation of the migration of Woodcock (Scolopax rusticola L.) in Transylvania. Based on the results of the synchronous Woodcock counting at the ten observation points in Transylvania, it can be stated that during the spring migration starting in the second decade of February, the number of observed birds showed an increasing trend until mid-March, so the migration can peak by the second decade of March based on the overall data from the ten observation points. Comparing the results of the synchronous Woodcock census in Transylvania and the Hungarian Woodcock Monitoring, it can be stated that, the course of the migration of the species in Transylvania shows a similar dynamic to the Hungarian data (FARAGÓ et. al., 2011, 2012a, 2012b, 2012c, 2014, 2015 a, 2015b, 2016, BENDE, 2021), but its peak can be dated to about 5–15 days earlier than the maximum experienced in Hungary (third decade of March). Based on the observation data recorded at the designated observation points in the lowland and mountainous regions and the difference detected by the analysis of variance, our study results confirm the phase-delayed Woodcock migration previously reported in the Romanian literature (MĂTIEȘ & MUNTEANU, 1976, 1979, 1980). Based on our results, the maximum experienced at the designated sampling sites in the lowland region is 10. March, while in the mountainous areas it is estimated to be 20. March. Examining the relationship between birds and observation sites, we concluded that the observations were independent of the sampling area although the order (magnitude) of the frequency values varied significantly in each area, and the frequency distributions observed at each observation point can be considered similar. One single year is not enough for a statistically reliable description of the spring migration characteristics of Woodcocks. Naturally, with such a small number of items (n = 253) it is not possible to find out the reasons for the differences emerging during the migration. We could only do so with a nationwide time-series dataset including a sufficiently large number of items, and at the same time, we would like to draw attention with our study to the need for wildlife biology research in connection with this species.
In memoriam Kovács Gábor (1951–2023)
Authors: Faragó Sándor
Published: July 2024

Türelemmel viselt rövid, de súlyos betegségben 2023. július 19-én Hortobágyon elhunyt Dr. KOVÁCS GÁBOR agrármérnök, ornitológus, természetvédő, a Hortobágyi Nemzeti Park nyugalmazott természetvédelmi felügyelője, akiben a MAGYAR VÍZIVAD MONITORING alapító tagját, a MAGYAR VÍZIVADKUTATÓ CSOPORT és a Magyar Vízivad Közlemények szerkesztő bizottságának tagját is gyászoljuk.
Edifício Linck: Avaliação Bioclimática de um ícone Moderno no Patrimônio de Porto Alegre (RS)
Authors: Domingues Quétilan Rodrigues , Souto Ana Elisa Moraes
Published: July 2024

A arquitetura bioclimática busca conceber edificações adaptadas ao clima e às características físicas específicas de cada localidade. Entre as estratégias amplamente utilizadas nessa abordagem, destacam-se elementos de proteção solar, como brises, grelhas e cobogós, entre outros. Essas intervenções consideram, adicionamente, os aspectos de ventilação e iluminação natural de cada contexto visando otimizar o conforto térmico e luminoso das construções de maneira sustentável. Nesse sentido, a arquitetura moderna é o campo em que esses elementos foram amplamente aplicados, tornando o patrimônio moderno um recorte potencial para estudos que buscam compreender a aplicação de estratégias bioclimáticas em edificações. Este artigo tem como objetivo realizar análises bioclimáticas sobre o Edifício Linck, uma construção multifamiliar projetada pelos arquitetos Emil Bered, Salomão Kruchin e Roberto Félix Veronese em 1952, na cidade de Porto Alegre. A investigação busca compreender e destacar as estratégias bioclimáticas implementadas no projeto arquitetônico, visando contribuir para a compreensão do papel desempenhado pela sustentabilidade na arquitetura moderna e no patrimônio arquitetônico de Porto Alegre. O edifício faz parte de um acervo de construções representativas da arquitetura moderna, marcando o início do período de maior produção do movimento moderno na capital gaúcha. A pesquisa utiliza o método de observação das fachadas por meio de visitação in loco, o redesenho e a consulta à NBR 15.220 que traz recomendações sobre parâmetros construtivos em pról do conforto térmico para edificações. Apesar de a edificação ser datada da década de 1950, período em que não existiam normativas sobre conforto térmico em edificações, a pesquisa destaca o uso eficiente das estratégias adotadas no prédio. Além disso, evidencia o domínio dos arquitetos envolvidos no projeto, tanto na escolha dos materiais em relação às suas propriedades quanto nos aspectos físicos presentes no local de implantação da obra.
Profiling the Surfaceome of Meningioma for Immunotherapeutic Target Identification v1
Authors: BIN ZUBAIR ABDULLAH , Awais Khan Muhammad , M. Hirte Renee , not provided mlabib , not provided dgandhi
Published: July 2024

This protocol aims to profile the surfaceome of meningioma tumors and matched healthy tissue to identify differentially expressed tumor cell-surface proteins and tumor-specific antigens. By using N-Glycocapture Mass Spectrometry, we will enrich and analyze the cell surface glycoproteins, allowing for the identification of potential immunotherapeutic targets. The protocol includes sample collection, tissue processing, N-Glycocapture enrichment, Mass Spectrometry analysis, and data interpretation. We anticipate that this protocol will provide valuable insights into the surfaceome of meningioma cells, enhancing our understanding of tumor biology and facilitating the development of precise, targeted immunotherapies.
The Attributes of Postmodern Pluralism, Skepticism, and Relativism in Selected Kurt Vonnegut’s Four Novels
Authors: Majeed Abdulhameed A.
Published: July 2024

This paper explores pluralism, skepticism, and relativism in Kurt Vonnegut’s Player Piano, The Sirens of Titan, Cat’s Cradle, and Slaughterhouse-Five. The study attempts to reveal Vonnegut’s depiction of contemporary postmodern politics, society, and culture. It looks into postmodernism as the inclusive term of the thematic attributes of pluralism, skepticism, and relativism which apparently imprint the typical image of postmodernism life. Therefore, the study sheds light on the selected novels’ perception of postmodernism on the verge of social and cultural change stimulated by politics that plays a crucial role in shaping postmodern man and his capacity to cope cultural pluralism. In this way, the study unravels such pluralism via highlighting the characters’ skepticism of their ability to grasp the relativism of postmodern life. The study examines Vonnegut’s postmodern dexterity as a critique of contemporary political actions that lead to new life styles. In addition, it discovers the selected novels’ narrative structure as a postmodern device of exposing contemporary socio-cultural reality that is spoiled by contemporary politics. In this way, it identifies Vonnegut’s postmodern fictional theme of relativism i.e., dealing with political sequences as challenging reality; and this reality should be amended by controlling postmodern politics.
An Appraisal System Analysis of Slogans in Political Campaign of Legislative Candidates in Tuban Regency, Indonesia
Authors: Widodo Mardi , Syahri Mohamad , Supriatna Usep , Sumadi Sumadi , Malyuna Sita Isna
Published: July 2024

This study aims to examine the use of the appraisal system, especially the attitude subsystem, and the judgement of appraisal in the political campaign slogans of legislative candidates in Tuban Regency. There have been many studies on political campaign slogans, but similar studies using appraisal theory have not been found. In fact, appraisal system analysis can help text readers understand the attitudes and judgments of text creators towards the things they communicate. The data in this study were analyzed using appraisal system theory. The data were obtained through the listening method and analyzed using the referential pairing method. The results show that judgment is the most widely used attitude subcategory in slogans. This shows that the advertisement creators emphasize judgment on human behavior, both towards themselves and others (society). Meanwhile, the most dominant subject and object of judgment is the legislative candidates themselves as slogan creators. This finding shows that legislative candidates in Tuban Regency tend to make subjective claims about their own qualities without quoting or displaying opinions from other parties in their political advertisements.
The Death of Monarchs: Front-Page Reporting of Queen Elizabeth II’s Death
Authors: Darwish Ibrahim M. , Alzoubi Abdulaziz A. , Ain Noora Q. Abu
Published: July 2024

This is a linguistic and semiotic study of the newspaper front pages that reported the death of Queen Elizabeth II. A sample of 61 front pages was collected from various British and non-British newspapers on Friday 9 September, 2022. The headlines reporting the death of the Queen were linguistically analysed focusing on euphemistic means. The pictures accompanying the headlines were semiotically investigated to see how the Queen was visually mourned and if there were any subtle semiotic euphemisms. Reporting the death of the Queen, linguistic and semiotic polarities can be observed on the newspaper front pages under investigation: direct versus indirect reporting. The findings reveal that 70.5% of the headlines reported the tragic news indirectly avoiding the verb ‘die’, the noun ‘death’ and the adjective ‘dead’. Similarly, the semiotic analysis shows that more newspapers displayed coloured (67%) recent (57%) pictures of the Queen showing her cheerful (56%). Avoiding the words ‘die’, ‘death’ and ‘dead’ and displaying the Queen in coloured cheerful pictures demonstrate that newspapers favoured both subtle linguistic and semiotic euphemisms in reporting the death of Queen Elizabeth II. The findings illustrate how humans, consciously and unconsciously, safeguard themselves against the discourse of death by utilizing both linguistic and semiotic euphemisms.
Language Learning Plateau: EFL Teachers’ Perceptions and Practical Recommendations
Authors: Utegulova Dinara , Koptleuova Kulpash , Bauyrzhan Nurkhanym , Mukhtarova Sandugash , Khairzhanova Akhmaral , Assylzhanova Danagul
Published: July 2024

This study explores EFL teachers’ perceptions of the language learning plateau and identifies the recommendations teachers have for overcoming it. Thematic analysis is used to analyse the data from ten English teachers who teach students from intermediate to advanced levels. The findings show that there is a lack of awareness of the term among EFL teachers, yet the idea of the plateau is familiar. Surprisingly, some teachers are found to be in the plateau themselves. This study also discusses the issues teachers are struggling with, and some useful strategies they use to help students move beyond the plateau.
Violencia en una sociedad violenta
Authors: Terris Milton
Published: July 2024

Se presenta la epidemiología descriptiva de la violencia en Estados Unidos. Las razones para las altas tasas de homocidio se exploran al describir el desarrollo historico de la violencia en Colombia, un país en desarrollo con tasas muy altas de homicidio, y en los Estados Unidos, que tiene las tasas extraordinariamente altas de homicidio comparadas con otros países altamente industrializados. Los factores históricos que contribuyen los Estados Unidos a las tasas tan altas de violencia incluyen el genocidio de la población india, el sistema de la esclavitud y la creciente militarización de la economía del país, la ideología y la política gubernamental. Se afirma que Estados Unidos es una sociedad violenta
La nueva constitución
Authors: Yepes Parra Antonio
Published: July 2024

Fueron muy intensos los debates sobre el papel del Estado y la privatización de los servicios públicos, que se cumplieron en la Comisión Quinta, encargada de los asuntos económicos, sociales, ecológicos, dentro de la Asamblea Nacional Constituyente. Dicho debate aún permanece vigente en el país.
Servicios de salud
Authors: Bersh Escobar David
Published: July 2024

Ciertamente, la tarea de pedagogía constitucional es el gran desafío del sector salud en Colombia, para hacer realidad la máxima decisión política del Estado a través de la Asamblea Nacional Constituyente.
Seguridad social y cajas de compensación
Authors: Nuñez Lapeira Alfonso
Published: July 2024

Voy a tratar de hacer un esbozo muy general diciendo que no es fácil hablar en un Seminario de seguridad social, en una Nación donde la mayoría de la población, lo que no tiene es seguridad social.
La violencia
Authors: Abad Gómez Héctor
Published: July 2024

La Epidemiología es tal vez el método científico más local y más actual, es decir, más de " aquí y de ahora" aplicable sólo a circunstancias que pueden ser claramente definidas en espacio y tiempo. En el estudio de este fenómeno que en Colombia hemos llamado "violencia", es también aplicable el concepto correlativo con el anterior, de que nada es igual siempre y en todo lugar.
Encuesta de prevalencia de transtornos menstruales y su relación con el habito de fumar
Authors: Florez T. Dr. John , Mazuera del H. Lic. María Eugenia
Published: July 2024

Se realizó un estudio de corte(cross sectional) con el fin de investigar la probable asociación entre fumar cigarrillo y trastornos menstruales. Se aplicó el formulario a 638 estudiantes de Nutrición y Dietética y de Enfermería de la Universidad de Antioquia. Se controlaron por el método de Mantel y Haenzel algunas de las variables de confusión , y se encontro una asociación con dismenorrea.Como el factor de riesgo investigado, y los controlados, se derivan del estilo de vida, se sugieren programas de educación para la salud a la comunidad con el fin de prevenir dicha patología.
Satisfacción laboral y síndrome de burnout en el personal de enfermería del Instituto Autónomo Hospital Universitario Los Andes (IAHULA), Mérida, Venezuela, 2005
Authors: Moreno B Reyla , Mejías M Zurayma , Rivas F Andreína , Rivas F Fernando , Cerrada S Jorge , Rivas P Fernando
Published: July 2024

Objetivo: el objetivo de la investigación fue determinar la frecuencia del síndrome de burnout y su relación con la satisfacción laboral en el personal de enfermería del Instituto Autónomo Hospital Universitario Los Andes, de Mérida, Venezuela. Métodos: la investigación es de tipo descriptivo y diseño transversal. Se utilizó una muestra de 104 trabajadores de la enfermería (83 mujeres y 21 hombres), de las áreas de hospitalización, unidad de cuidados intensivos y emergencias obstétrica, pediátrica y de adultos, que se eligieron mediante muestreo aleatorio estratificado. Se aplicó una encuesta de variables sociodemográficas; el cuestionario de Maslach Burnout Inventory (MBI) y el cuestionario de escala de satisfacción laboral de Warr, Cook y Wall. Resultados: los valores obtenidos fueron de 15,42±10,79 en cansancio emocional; 5,58±5,45 en despersonalización y 40,21±6,83 en realización personal. Un 6,73% presentó burnout. Se obtuvo una media de 35,72±8,94en satisfacción intrínseca; 30,67±9,19 en la extrínseca y 66,39±17,21 en la general. Conclusión: se concluye que el nivel de burnout es bajo, aunque hay un riesgo epidemiológico alto. Existe un nivel moderado de satisfacción, dada principalmente por factores intrínsecos al trabajo. Las variables sociodemográficas tienen un bajo efecto en las dimensiones del síndrome.
Construcción cultural del concepto calidad de vida
Authors: Cardona A Doris , Agudelo G Héctor Byron
Published: July 2024

Objetivo: hacer una revisión narrativa a la construcción del concepto de calidad de vida, su historia y evolución, pasando por diferentes enfoques y paradigmas que lo moldean de acuerdo con los significados culturales del momento. Materiales y métodos: se realizó una revisión bibliográfica, expuesta en forma narrativa, a algunos autores que abordan el concepto de calidad de vida desde diferentes enfoques. Resultados: el concepto de calidad de vida ha pasado de ser una forma abstracta del bienestar y felicidad a ser considerado operativamente como el nivel de vida y condiciones de vida según diferentes disciplinas y áreas del saber, tanto filosóficas y éticas como económicas, sociales y culturales. Conclusiones: la construcción de significados culturales y representaciones sociales de un individuo parten de un proceso mental formado desde el contexto en el que vive y se desarrolla, que le dan sentido a la vida y hacen que esta tenga calidad.
Efectos auditivos del ruido producido por el tráfico aéreo del aeropuerto internacional El Dorado en las poblaciones de Engativá y Fontibón
Authors: Londoño Juan , Restrepo O Hernando , Vieco G Fernando , Quinchía Rigoberto
Published: July 2024

Objetivo: se realizó un estudio con el fin de evaluar el efecto del ruido del tráfico aéreo en la capacidad auditiva de los habitantes de las localidades vecinas al aeropuerto. Materiales y métodos: se utilizó un diseño de cross-sectional con base en muestras aleatorias poblacionales de escolares y de adultos expuestos y no expuestos al ruido. Se consideró como exposición un nivel de 65 dB(A) Ldn o más en la vivienda, o un nivel de exposición individual Lmax o SEL de 85 dB(A) o superior. Para la evaluación de la capacidad auditiva se utilizó la audiometría tonal liminar y el análisis de los resultados se hizo con base en los índices ELI y Larsen y la disminución en decibeles del umbral auditivo. Se comprar ó la prevalencia cruda de hipoacusia en expuestos y no expuestos y luego se utilizó un modelo de regresión logística para ajustar la comparación por múltiples variables. Resultados: según los índices ELI extendido (6.000 hercios) y Larsen, la hipoacusia fue significativamente mayor en los escolares y en los adultos expuestos, con prevalencias que superan a las de los no expuestos en 43 y 15% (en escolares, respectivamente) y en 32 y 11% (en adultos); según el índice ELI (4.000 hercios), también la prevalencia en los adultos expuestos fue significativamente mayor en un 3% que en los no expuestos.
Supervivencia de niños con bajo peso al nacer en una unidad de cuidados intensivos neonatal, Medellín, 1997-2001
Authors: Muñoz Juan Fernando , Grisales R Hugo
Published: July 2024

Objetivo: determinar la supervivencia de los niños con bajo peso al hospitalizarlos en la unidad de cuidados intensivos neonatal de un hospital de tercer nivel de complejidad de la ciudad de Medellín, entre 1997 y 2001, con el fin de identificar algunas características relacionadas con la probabilidad de morir y con el tiempo de supervivencia del recién nacido. Metodología: con base en una población de 809 recién nacidos, se recolectó la información afín al objetivo. Para estimar la supervivencia se construyeron las tablas de vida pertinentes y para valorar la significación de esta con respecto a variables de interés, se utilizó el método de Kaplan-Meier, el log rank test y el modelo de riesgos proporcionales de Cox. Resultados: de los 809 recién nacidos, 50% ingresaron al servicio en menos de 24 horas después de haber nacido, donde alcanzaron una estancia promedio de 7,8 días, tiempo en el cual la enfermedad de membrana hialina se¡ presentó en 76% de ellos. La supervivencia acumulada de los niños disminuyó gradualmente en una tasa de 50% en los primeros 28 días de hospitalización y a partir del día 29, el descenso fue más lento; se destaca que antes de completar los 7 primeros días de hospitalización, se presentaron 59,7% de las defunciones. Durante la hospitalización, 51,5% de lo niños con excesivo bajo peso al nacer fallecieron.