bluuebunny/crossref_metadata_2025 huggingface dataset:
Molluscs as Experimental Models for the Study of Mucomics
Authors: Mentino Donatella , De Blasi Carlotta , Semeraro Daniela , Mastrodonato Maria , Guglielmi Marco Vito
Published: February 2025

Mucomics is the study of mucus and its biochemical properties. This discpline has gained increasing attention due to the critical roles mucus plays in protection, adhesion, and communication across species. Ethical restriction on vertebrate research have driven interest in invertebrate models such as molluscs. Molluscs produce a large amount of mucus which several functions including immune defense, digestion, and environmental adaptation. Molluscs - terrestrial, freshwater, or marine - are valuable models for investigating mucus composition and its responses to environmental stressors, including heavy metal contamination. Histochemical and glycomic techniques have revealed variations in mucin glycosylation patterns that influence mucus functionality, such as its viscoelastic and adhesive properties. Bivalves, widely used as bioindicators, accumulate pollutants in their mucus, reflecting environmental health. Investigative techniques such as lectin histochemistry, proteomic, and glycomic analyses provide insights into the impact of contaminants on mucus composition. Further research on molluscan mucins can enhance understanding of their physiological roles, environmental interactions, and potential biomedical applications. By integrating molecular and histochemical approaches, mucomic studies offer a comprehensive perspective on mucus function, advancing both ecological monitoring and biotechnological applications.
In Silico Screening of Epitopes as Potential Vaccine Candidates Against Pathogenic Acinetobacter baumannii
Authors: Islam Md Minarul , Lee Je Chul , Shin Woo Shik , Oh Man Hwan
Published: February 2025

Multidrug-resistant (MDR) Acinetobacter baumannii possesses a pressing threat to global healthcare settings, as most antibiotics are ineffective against this nosocomial pathogen. Vaccines, particularly peptide-based vaccines, offer a promising and effective strategy to deal with these infections. This study employed advanced bioinformatic tools to identify potential epitopes for vaccine candidates against A. baumannii infections. Three epitopes (EP1, EP2, and EP3) derived from A. baumannii OmpA were found to effectively bind with specific human leukocyte antigen (HLA) alleles. These epitopes have shown promising potential to elicit both cellular and humoral immune responses. Their physicochemical and immunological properties were thoroughly evaluated, indicating strong antigenic potential, non-toxicity, lack of allergenic properties, good binding affinity, and wide population coverage. The epitopes' two- and three-dimensional structures were predicted, and they were docked with their respective HLA alleles to assess their ability to stimulate innate immune responses. The predicted epitopes and HLA-allelic complexes exhibited excellent binding affinity, optimal Root Mean Square Deviation (RMSD) values, favorable physicochemical properties, and high-quality structural characteristics. Therefore, these in silico screened epitopes hold promise as potential solutions for combating multidrug-resistant A. baumannii, pending validation through wet lab experiments and clinical trials.
Adaptations of the Autonomic Nervous System and Body Composition After 8 Weeks of Specific Training and Nutritional Re-education in Amateur Muay Thai Athletes: A Clinical Trial
Authors: de Andrade Junior Antonio Beira , de Andrade Elena Marie Peixoto Ruthes , de Souza Guilherme Rodrigues , Lopes Agnaldo José
Published: February 2025

Background: Considering that the autonomic nervous system plays an important role in cardiac autonomic modulation (CAM) and that low CAM is associated with cardiovascular mortality, it is essential to evaluate the effects of training to increase parasympathetic modulation in Muay Thai (MT) athletes. Therefore, the aim of this study was to evaluate the effects of an 8-week intervention based on strength training and nutritional counseling on performance, CAM, and nutritional status in amateur MT fighters. Methods: This is a longitudinal and interventional study in which 22 MT fighters underwent a strength training program and nutritional protocol. Before and after the intervention, they underwent the ten-second frequency speed of kick test (FSKT-10s), multiple frequency speed of kick test (FSKT-mult), bioimpedance analysis (BIA), and assessment of heart rate variability. Results: After the intervention, there was an increase in the number of kicks in both FSKT-10s and FSKT-mult (p = 0.0008 and p = 0.032, respectively). In BIA, there was a significant decrease in fat-free mass and a significant increase in basal metabolic rate (p = 0.031 and p = 0.020, respectively). After the intervention, significant increases were observed during the fight in the following variables that denote improvement in parasympathetic modulation: square root of the mean squared differences of successive RR intervals (p = 0.005); percentage of adjacent RR intervals with a difference in duration greater than 50 ms (p = 0.002); high frequency range (p < 0.0001); and standard deviation measuring the dispersion of points in the plot perpendicular to the line of identity (p = 0.004). Conclusions: In amateur MT athletes, an intervention with strength training and nutritional guidance is able to improve CAM through greater parasympathetic activation. Furthermore, there is an improvement in performance and body composition after the intervention.
Intensity Parameters and Physical Damage in Buildings Due to the Mass Movements Occurred between 3 and 5 November 2019, in Jericó, Antioquia, Colombia
Authors: Silva-Ceron Alfer L. , Prieto Jorge A. , Badillo Jorge W.
Published: February 2025

Between 3 and 5 November 2019, mass movements occurred in Jericó, Antioquia, Colombia. Fortunately, no fatalities were reported during the events; however, five houses collapsed, two houses had damaged facade walls, and one power pole collapsed. Based on this, an analytical, probabilistic methodology is used to quantify the hazard intensity that occurred and affected the buildings. Initially, a technical description of the buildings and the damage caused is made. Three critical events are detected for hazard analysis, i.e. two related to landslides and one to debris flow. The hazard intensity is then quantified by determining the probabilistic parameters of velocity, dynamic thrust, momentum flux and overturning moment of the flow that caused damage to the different structures. These data are contrasted with the damage state thresholds for the overall behaviour of structures available in the literature. A structural fragility model in the out-of-plane direction in unreinforced masonry infill walls is used to obtain local complete damage thresholds. In addition, a complete damage threshold is calculated for the power pole. This study provides additional data that can strengthen knowledge related to the assessment of infrastructure risks associated with mass movements.
Exploring Dendroflora Diversity and Ecology in an Urban Park from Western Romania: The Role of Plant Life-Form and Plant Family in Urban Woody Phytocoenosis
Authors: Iordache Madalina , Zamfir Laurentiu , Becherescu Alexandra , Chis Codruta
Published: February 2025

The dendroflora of an urban arboretum, consisting of 193 species, was ecologically characterized as bioforms, phytogeographical elements, and preferences for moisture, temperature, and soil reaction. The inventoried species are grouped in 111 genera and 45 families. The native and non-native dendroflora share 16 common families. The most representative family both in the native and non-native dendroflora is Rosaceae. The monotypic families are largely present (22.22% in the native dendroflora, and respectively 42.22% in the non-native dendroflora). The plant life-form spectrum is dominated by megaphanerophytes (49%), followed by mesophanerophytes (41%). The chorological spectrum of the native species comprises 16 chorological types and is dominated by Eurasians (32%) and Europeans (30%). The species characteristics of the Pontic-Carpathian space, to which Romania belongs, are rare in the analyzed urban park (4%). The mesophyte, mesothermal and slightly acido-neutrophilous species dominate both the native and non-native dendroflora. In the adaption process of the non-native dendroflora, 37% of species exceeded their native requirements for moisture, 41% for temperature, and 50% for soil reaction. The species requirements for temperature are associated to those for moisture and soil reaction. The results show the potential of the analysed woody species to exceed their native requirements within the acclimation and adaption process, and in this process, for the studied temperate site, the plant life-form is important, and also the plant family. The species of the analyzed urban arboretum, both native and non-native, are taxonomically and biogeographically diverse, with specific habitat requirements, suggesting their great ability in acclimating, adapting and resisting.
Prediction of Oil Films on the Ocean: An Analysis of the Impact of Meteoceanographic Variables and Total Oil and Grease During Primary Petroleum Processing
Authors: Streitenberger Simone C , Romão Estevão L , Almeida Fabricio A , Souza Antonio Carlos Zambroni de , Orlando Jr. Aloisio E , Balestrassi Pedro Paulo
Published: February 2025

The presence of oil films in the ocean poses a significant environmental challenge for companies engaged in primary oil processing on offshore platforms. During crude oil treatment, residual water containing oils and greases (TOG) is discharged back into the ocean, potentially leading to the formation of oil films. The interaction between TOG levels and meteoceanographic variables — including wind direction (WD), wind speed (WS), current direction (CD), current speed (CS), wind wave direction (WWD), and peak period (PP) — influences the formation and satellite detection of these films. This study investigates the impact of these factors on the occurrence, detection, and extent of oil films using various statistical classifiers. Key findings reveal that Random Forest outperformed other classifiers, achieving an area under the ROC curve of 0.93. The combined use of classifiers, multivariate techniques, desirability analysis, and Design of Experiments (DOE) proved highly effective. Higher values of WS, WD, and CS were associated with a lower likelihood of oil film occurrence and detection, whereas higher TOG, PP, WWD, and CD values increased this probability. CS and TOG positively contributed to the extent of oil films, while high WS values reduced it. These results provide a robust decision-support framework for monitoring and mitigating the environmental impacts of offshore oil processing operations.
Effectiveness of Nickel-Titanium Files for Retreatment of Molars Filled with Single-Cone Hydraulic Technique Using Bioceramic Sealers: An In Vitro Study
Authors: Lee Jane , Kim Hyeon-Cheol , Kirkpatrick Timothy , Jaramillo David E , Kwak Sang Won , Jeong Ji Wook
Published: February 2025

Recently single-cone hydraulic canal filling technique using bioceramic sealers brought a difficulty of retreatment due to the mechanical properties of the bioceramic sealers. This study assessed the effectiveness of four nickel-titanium rotary files in removing gutta-percha and bioceramic sealer from molar root canals in vitro. Eighty-eight root canals from extracted molars were instrumented with Vortex Blue rotary files and filled with gutta-percha and bioceramic sealer using a single-cone technique. After 30 days, the filled canals were randomly divided into four groups according to the file used for re-instrumentation: ProTaper Gold (PTG), Endo ReStart (ERS), XP-3D Shaper (XPD), and HyFlex Remover (HFR). The study assessed whether root canal filling material removal and patency were achieved within a 10-minute time frame, recording the time required in seconds. The rate of regaining patency and the time required to achieve patency were compared between groups using a generalized linear model. Scanning electron microscopy were used to evaluate the mechanical changes on the files. The patency rate of XPD and HFR was significantly higher than PTG. ERS and XPD demonstrated shorter patency times than HFR and significantly shorter patency times than PTG. SEM images revealed a varied range of reverse windings across file groups. PTG and ERS exhibited microcracks and fractured tips, while XPD and HFR did not display these mechanical alterations. The four file systems in this study displayed varying levels of effectiveness in the retreatment of root canals filled with bioceramic sealers.
Navigating Supply Chain Challenges with Digital Transformation for Agility and Resilience
Authors: Holloway Samuel
Published: February 2025

This research examines the impact of digital transformation on improving supply chain agility and resilience, highlighting the growing need for firms to use sophisticated technologies to sustain competitiveness in a swiftly evolving business landscape. The study examines the role of digital technologies, including artificial intelligence, blockchain, big data analytics, and the Internet of Things, in enhancing supply chain efficiency, facilitating real-time decision-making, and improving adaptation to disruptions. The report offers a thorough examination of how digital transformation enhances responsiveness and operational performance by addressing critical elements such as leadership commitment, cooperation, and sustainability. The study technique used a qualitative approach, emphasizing topic analysis to extract insights from industry specialists. The results indicate that firms adopting digital transformation achieve significant enhancements in risk management, operational efficiency, and stakeholder collaboration. Leadership is essential for the effective implementation of digital projects, facilitating cultural transformations, and aligning organizational strategy with technology progress. Sustainability is a crucial element, as organizations incorporate environmentally responsible practices into their supply chain strategy to fulfill regulatory and customer demands. The research also delineates obstacles linked to digital transformation, such as reluctance to change, cybersecurity issues, and the intricacy of assimilating new technology with current systems. Notwithstanding these challenges, the study emphasizes the need of a comprehensive strategy that integrates technology, leadership, and cooperation to attain enduring resilience and agility. This study's findings provide essential direction for firms aiming to improve their supply chain capabilities via digital transformation, presenting a framework for managing the complexity of contemporary supply networks.
Upgrading Data Governance to Improve Disability-Related Services in Thailand
Authors: Chaiyasuk Sitthisak , Rugchatjaroen Krish , Sirisunhirun Somboon , Dhirathiti Nopraenue Sajjarax , Amornsiriphong Somsak , Ploywan Phut
Published: February 2025

Ensuring effective data governance is essential for delivering transparent, accessible, and equitable public services, particularly for people with disabilities. However, chal-lenges such as gaps in data oversight and accountability hinder service efficiency and transparency. This study examines the relationship between data-driven culture, audit data governance, and public service performance, employing Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and Path Analysis. The findings indicate that a strong data-driven culture enhances audit data governance, improving service transparency, accessibility, and user satisfaction for people with disabilities. Public service delivery significantly influences audit data governance through data accessibility, ethical management, and efficient administrative processes. To promote inclusive governance, this study highlights the need for open data policies, in-ter-agency collaboration, and emerging technologies such as AI and blockchain. Policy recommendations focus on data-driven decision-making frameworks that align with OECD principles, ensuring equitable and accountable public services for people with disabilities.
The 2023 Major Baltic Inflow Event Observed by SWOT Altimetry
Authors: Esselborn Saskia , Schöne Tilo , Dobslaw Henryk , Sulzbach Roman
Published: February 2025

The Baltic Sea is an intercontinental marginal sea that is vertically stratified with a strong halocline isolating the saline bottom layer from the brackish surface layer. The surface layer is eutrophic and abiotic zones lacking oxygen are common in the deeper regions. While freshwater is constantly flowing into the North Sea, oxygen-rich bottom waters can only occasionally enter the Baltic following a special sequence of transient weather conditions. These so-called Major Baltic Inflow events can be monitored via the sea level gradients between the Kattegat and the western Baltic Sea. Innovative interferometric altimetry from the Surface Water and Ocean Topography (SWOT) mission give us the first opportunity to directly observe the sea level signal associated with the inflow in December 2023. In addition, we use observations from recent high-rate multi-mission nadir altimetry. For scales larger than 50 km, SWOT and nadir altimetry are in very good agreement. The SWOT observations are compared to the simulations with the regional 3D HBMnoku ocean circulation model operated by the German Federal Maritime and Hydrographic Agency (BSH). Both agree very well for most aspects. The north-south gradients of the two data sets differ by about 10% of the total value. Comparison with tide gauges suggests that there may be model deficiencies on daily to sub-daily time scales. In addition, the SWOT data have many fine scale structures such as eddies and fronts that cannot be modelled adequately.
Right Ventricular and Left Atrial Strain Predict Volumetric Response to Cardiac Resynchronization Therapy
Authors: Ching Shing , Li Jeffrey Ji-Peng , Werhahn Stefanie Maria , Beyer Rebecca Elisabeth , Estepa Martinez Misael , Stehning Christian , Hashemi Djawid , Solowjowa Natalja , Klein Christoph , Dreger Henryk , Kelle Sebastian , Doeblin Patrick Johannes
Published: February 2025

Background: While left-bundle-branch-block-related contraction patterns as well as echocardiography derived strain are variably associated with volumetric response to cardiac resynchronization therapy (CRT), the role of CMR-derived strain parameters is unexplored. Methods: 50 patients receiving CRT implantation were retrospectively analysed, all of which had undergone CMR imaging within one year before, and echocardiography within 6 months before and 6-12 months after CRT implantation. We assessed CMR-derived morphological and functional parameters with regard to echocardiographic response, defined as reduction of left ventricular end-systolic volume ≥15%. Results: Among standard CMR parameters, indexed right ventricular volumes in end-diastole (RVEDVi) (74.5 ±19.5 vs. 94.8 ±30.2 ml/m², P=.006) and end-systole (RVESVi) (43.2 ±13.3 vs. 61.6 ±28.8 ml/m², P=.003) as well as left atrial (LA) area (24.8 ±3.5 vs. 30.4 ±9.5 cm², P=.020) differed significantly between CRT responders and non-responders. In strain analysis, CRT responders showed significantly better LA global longitudinal strain (GLS) (25.1 ±10.4 vs. 15.3 ±10.5, P=.002), LA global circumferential strain (GCS) (27.9 ±14.7 vs. 17.1 ±13.1%, P=.012), RV GLS (-25.0 ±6.5 vs. -18.9 ±7.6%, P=.004) and RV free wall strain (-31.1 ±7.9 vs. -24.9 ±9.5, P=.017). Conclusions: CMR-derived peak septal circumferential strain and RVEDVi correlated with echocardiographic volumetric response to CRT at 6-12 months.
Phased Array Antennas: Advancements and Applications
Authors: Giannakopoulos Georgios , Shaikh Khushbu Mehboob
Published: February 2025

Phased array antennas provide the ability to electronically steer a beam, eliminating the need for mechanical adjustments [1]. While traditionally used in military applications, there is growing interest in their adoption across various fields [1,2]. Conformal antennas, a type of phased array, are designed for installation on curved or non-flat surfaces, enabling focused radio wave radiation [1,2]. These antennas can be integrated into various applications, including aerospace, wearable technology, vehicles, and modern mobile devices [2], while also reducing traditional antenna height to support the integration and coexistence of multiple radio technologies within a compact area [1,2]. Planar arrays, composed of elements with phase shifters in a matrix, are compact and cost-effective due to mass production via printed circuit technology [1–3]. These antennas, when mounted on rigid surfaces, exhibit robustness, provide beam deflection in two planes, and offer high gain with rapid beam-switching capabilities [1,3]. However, planar antennas can experience interference between feed lines and elements, often supporting narrow bandwidths and exhibiting relatively low radiation efficiency [1,3]. Conformal antennas, which are easily mounted on curved surfaces, are particularly suited for wearable applications, spacesuits, and aerospace designs [1,2,4]. By minimizing connection length, they bring electronics closer to the antenna elements, reducing signal loss while enhancing transmission power and receiver sensitivity, especially at higher frequencies [4]. Research into 3Dprinted conformal antennas has emerged as a significant field of study [1,5]. This paper presents the mathematical analysis of both planar and conformal antennas, covering key parameters such as gain, bandwidth, radiation efficiency, and mutual coupling for planar arrays, as well as the width and length calculations for rectangular microstrip patch antennas used in conformal designs [2,6–8]. Furthermore, the role of additive manufacturing in antenna development is highlighted, emphasizing its ability to produce antennas with complex geometries thereby revolutionizing conformal antenna design [1,9].
The Transcription Machinery Driving Force: Why Did Nature Choose Phosphates?
Authors: Riera Aroche Raúl , Sánchez Moreno Esli C. , Ortiz García Yveth M. , Machado Sulbarán Andrea C. , Riera Leal Lizbeth , Olivas Román Luis R. , Riera Leal Annie
Published: February 2025

The dynamic phosphorylation of the human RNA Pol II CTD establishes a code applicable to all eukaryotic transcription processes. However, the ability of these specific post-translational modifications to convey molecular signals through structural changes remains unclear. We previously explained that each gene can be modeled as a combination of n circuits connected in parallel. RNA Pol II accesses these circuits and, through a series of pulses, matches the resonance frequency of the DNA qubits, enabling it to extract genetic information and quantum teleport it. Negatively charged phosphates react under RNA Pol II catalysis, increasing the electron density on the deoxyribose acceptor carbon. The first pulse of phosphorylation connects tyrosine to the nitrogenous base, while the subsequent pulses link the protein to molecular water through hydrogen bonds. The coupling of hydrogen proton transfer with electron transfer in water generates a supercurrent, which is explained by the correlation of pairs of the same type of fermions exchanging a boson. All these changes lead to the formation of a molecular protein-DNA-water condensate.
Research of the Process of Obtaining Monocalcium Phosphate from Unconditional Phosphate Raw Materials
Authors: Anarbayev Abibulla , Kabylbekova Balzhan , Khussanov Zhakhongir , Smailov Bakyt , Anarbaev Nurlan , Kulikov Yevgeniy
Published: February 2025

In the chemical industry, one of the promising areas is the development of effective technologies for obtaining high-quality mineral fertilizers and feed mineral fertilizers from unconditional phosphate raw materials and improving their technical and economic indicators and agrochemical properties of products. Moreover, the solution to these problems should be carried out on the basis of low-grade raw materials poor in phosphorus content. Such low-grade ores include phosphorites of the Chilisay mine. Phosphorites of this deposit have a number of specific features that create certain difficulties and contain a large number of carbonates, in terms of carbon dioxide reaching 4.56-6.34%, as well as glauconites. When decomposing such phosphorites, large volumes of very stable foam are formed, which complicates the decomposition of phosphorus raw materials and reduces the useful volume of the decomposition chamber by 60-80%, increases the loading time of phosphorite and, accordingly, increases the total time of the process. The objective of the work is to research the process of obtaining high-quality monocalcium phosphate, as well as to determine the optimal decomposition parameters of low-grade phosphate raw materials and to increase the product yield. Based on the conducted research of the Chilisayphosphorite decomposition, monocalcium phosphate was obtained.
Use of Alternative Materials in Sustainable Geotechnics: State of World Knowledge and Some Examples from Poland
Authors: Jastrzębska Małgorzata
Published: February 2025

Geotechnical engineering projects carried out within the framework of the low-emission econ-omy and the circular economy are the subject of many publications. Some of these studies pre-sent the use of various waste materials, as soil additives, for improving geomechanical behav-ior/properties. Many of these materials are eagerly used in geoengineering applications, pri-marily to strengthen weak subsoil, or as a base layer in road construction. Information on indi-vidual applications and types of these materials is scattered. For this reason, this article briefly discusses most of the major waste materials used for achieving weak soil improvement in ge-oengineering applications, and highlights pertinent bibliographic sources where relevant details can be found. The presented list includes waste from mines, thermal processes, end-of-life car tires, chemical processes (artificial/synthetic fibers), and from construction, renovation and demolition works of existing buildings and road infrastructure. In addition to the positive im-pact of using waste instead of natural and raw materials, the paper encourages the reader to ponder whether the waste used really meets the criteria for ecological solutions.
Peculiarities of Soil Tillage in Southeastern Kazakhstan
Authors: Rzaliyev Askar , Goloborodko Valeriya , Bekbosynov Serik , Seipataliyev Olzhas , Kosherbay Dauren
Published: February 2025

This study examines the impact of various tillage practices on the agrophysical and hydrophysical properties of sierozem and light chestnut soils in Southeastern Kazakhstan. The objective is to develop an optimized tillage strategy to enhance soil fertility and moisture conservation. The research evaluates both conventional and innovative tillage methods, analyzing their effects on soil erosion, structure, and water retention. Field trials demonstrated that replacing traditional moldboard plowing with chisel and flat-cutting tillage, along with combined implements for leveling, crushing, and rolling, significantly reduces erosion and improves moisture retention. The results suggest that adopting alternative tillage technologies can enhance soil conservation and crop productivity while reducing operational costs.
Dynamics of Membrane Tension Propagation in Eukaryotic Cells
Authors: Mubasshar Shahid
Published: February 2025

The propagation of membrane tension perturbations is a potentially critical mechanism in the mechanical signal transduction across the surfaces of living cells. Tethered proteins in the cell membrane play a crucial role in the propagation of the membrane tension. Intact cell membranes in eukaryotic cells possess unique characteristics, such as transmembrane proteins bound to the underlying cortex, rendering them immobile over timescales of minutes to hours. These immobile obstacles significantly alter the dynamics of lipid flow. While existing simplified lipid flow models provide fundamental insights into membrane tension dynamics, they fall short in accounting for complex phenomena like vesicle crumpling. To address this, we propose a more sophisticated model of lipid bilayers, solving the Stokes equations in a two-dimensional framework with embedded obstacles. We employ the finite element method and the FEniCS library to solve the weak form of the Stokes equations, providing a more accurate representation of membrane behaviour under physiological conditions.
Impact of Exhaust Manifold Design on Internal Combustion Engine Performance
Authors: Jamshidi Darioush , Poureyvaz Borazjani Daniyal , Hosseini Seyed Ehsan , Davari Sajad
Published: February 2025

Optimizing the design of the exhaust manifold plays a crucial role in enhancing engine efficiency, reducing fuel consumption, and minimizing pollutant emissions in internal combustion engines. This study aims to improve the exhaust manifold geometry of the M3 engine, manufactured by PIDOCO (Pioneer Intelligence Design Origin Co.). The primary design objectives include reducing pressure drop and enhancing flow uniformity across the surface of the monolithic catalyst. To achieve these goals, a modified exhaust manifold geometry for the M3 engine was designed, and Computational Fluid Dynamics (CFD) simulations were conducted to evaluate the proposed designs. The geometries were created using CATIA software, while ANSYS Fluent was employed for CFD analysis. The results indicate that optimizing the exhaust manifold geometry reduces pressure drop by 45%, improves the flow uniformity index by 36%, and leads to a minimum 4.5% reduction in vehicle gaseous emissions.
La Ley Orgánica del Sistema Universitario y la innovación docente: especial referencia a la economía social
Authors: Domínguez Cabrera María del Pino
Published: February 2025

Este trabajo pretende la exposición de una circunstancia jurídica a la que la enseñanza universitaria se ve abocada que es la innovación y la posibilidad de que dicha innovación docente verse específicamente en el tipo societario que configura el cuadro de la economía social. Dentro del ámbito del Derecho mercantil la economía social se visualiza como fórmula colectiva de organización social para lograr, mediante el esfuerzo y recursos comunes, soluciones que no se pueden lograr individualmente y es a la organización resultante, a la que le toca asumir las consecuencias positivas y negativas de los riesgos que su actuación en el ámbito económico que genere. Con ello, y la legislación universitaria de pertinente aplicación, se constata que la innovación docente se convierte en contenido imprescindible en la labor de las universidades y por ende de la labor de las/os docentes, de forma que queda configurada en una estrategia fundamental de las universidades, de los centros y de las coordinaciones de las titulaciones, y ello teniendo presente que el objeto esencial del proceso educativo es enseñar y aprender sin perder de vista que esta labor debe adaptarse a los cambios sociales, económicos, tecnológicos y culturales que se desarrollan en cada momento histórico. Con la propuesta que realizamos en este trabajo, la innovación docente y los valores de la economía social , a través de la propuesta de proyecto docente que los incorpore, se está evidenciando que las universidades al transformar sus formas de aprendizaje y de enseñanza se adaptan a las demandas de unas sociedades en permanente cambio. Así, se expone i.- el marco jurídico de la economía social sin perder de vista la normativa de la Comunidad Autónoma de Canarias en este ámbito; ii.- la relación directa de la regulación del sistema universitario español y la economía social con iii.- una propuesta innovadora plasmada en el proyecto docente de la asignatura Derecho de Sociedades correspondiente al ámbito del Derecho mercantil .
Presentación
Authors: Montesinos Padilla Carmen
Published: February 2025

Presentación del número 23 de la Revista Docencia y Derecho. Monográfico coordinado por Carmen Montesinos Padilla, Letrada del Tribunal Constitucional de España y Profesora de Derecho Constitucional,  reflejo de la sesión del grupo de innovación docente de la Asociación de Constitucionalistas de España celebrada el pasado 7 de marzo de 2024.
La enseñanza del Derecho y el profesor universitario en la universidad bononiense: una aproximación conservadora para la formación de juristas integrales
Authors: Teruel Lozano Germán
Published: February 2025

Este trabajo pretende indagar sobre el sentido de la universidad y de la formación que debe ofrecer, centrándose en el ámbito jurídico, para destacar aquello que debe preservarse en la universidad española resultante de la reforma de Bolonia. A este respecto, se apostará por la formación de juristas “integrales”, personas doctas en la disciplina jurídica, cultas y con un fondo ilustrado, comprometidas socialmente y con destrezas para el genérico desempeño de profesiones jurídicas. Por último, se reflexionará sobre el modelo de profesor universitario, el cual se defiende que debe alejarse de la degradación ludópata hoy tan extendida y del paradigma impuesto por los sistemas de evaluación docente actuales. Se termina identificando cuáles han de ser las virtudes de un enseñante, los métodos que debe seguir y las competencias a desarrollar en sus alumnos si tiene como objetivo ese ideal de formación integral
La enseñanza inclusiva del Derecho Constitucional al alumno con necesidades educativas especiales: cómo hacer de la necesidad una virtud.
Authors: Garrido Raya Andrea
Published: February 2025

El presente trabajo pretende inducir a reflexionar sobre el nivel de preparación con el que cuenta hoy nuestro sistema universitario para afrontar la diversidad presente en las aulas. Tras haber finalizado mi primer año como docente de la asignatura de Derecho Constitucional I a alumnos con necesidades educativas especiales (NEE), en este artículo trato de sugerir técnicas de innovación docente basadas en empatizar con el alumno y hacerlo partícipe del sistema, para con ello promover una enseñanza plural, justa y de calidad
Impacto de la conectividad digital en la gestión del emprendimiento de las integrantes de la Red Regional de Mujeres Emprendedoras y Empresarias de Huánuco (Perú), (2024)
Authors:   , Alvarado Villanueva Jose Luis Maicu , Tolosana Estirado Emilio Jose
Published: February 2025

Este estudio examina el impacto de la conectividad digital en la gestión del emprendimiento de las integrantes de la "Red Regional de Mujeres Emprendedoras y Empresarias de Huánuco" (Perú, 2024). La investigación, de tipo aplicada con enfoque cuantitativo diseño no experimental, transversal y alcance correlacional-causal, destaca la importancia de las tecnologías de información y comunicación para el empoderamiento económico y social de las mujeres en la región. Se aplicó un cuestionario Likert de 24 ítems a 87 integrantes de la red. Los resultados revelan un impacto positivo y significativo de la conectividad digital en la gestión del emprendimiento, donde se llevó a cabo un modelo de regresión logística ordinal demostrando una influencia del 59.9% en la variable dependiente. Este hallazgo subraya el potencial de la conectividad digital para impulsar el desarrollo sostenible y el empoderamiento de las mujeres empresarias en Huánuco, una región que enfrenta desafíos multifacéticos en un entorno empresarial cada vez más digitalizado.
Evaluación del almacenamiento de carbono y volumen de agua en el suelo del bofedal de la comunidad de Cullhuay, Canta (Lima-Perú)
Authors:   , Ayala Mena Diana Stefany , Valerio Ariza Rosycela
Published: February 2025

Los bofedales son ecosistemas altoandinos que brindan servicios ecosistémicos como la captura de carbono y almacenamiento de agua. Estos ecosistemas se encuentran constantemente amenazados a causa del sobre pastoreo, la construcción de infraestructuras viales, manejo inadecuado de agua y la extracción del material orgánico para su comercialización. Estos factores traen como consecuencia la reducción de la extensión de los bofedales, compactación del suelo, disminución de la capacidad de retención de agua y carbono, así como liberación del CO2 almacenado. Esta investigación estima la cantidad de carbono y volumen de agua almacenado en el suelo de un bofedal de la comunidad de Cullhuay, provincia de Canta, departamento de Lima. Para ello, se analizaron 45 muestras aleatorias en tres zonas (seca, húmeda y saturada), se calcularon parámetros como densidad aparente (método del cilindro de volumen conocido), porcentaje de carbono (la ecuación de Van Benmelen) volumen gravimétrico y volumétrico (método por pérdida de peso). Los resultados muestran que el total de carbono almacenado en los primeros 30 cm de profundidad de suelo del bofedal de Cullhuay es 957.69 tC (6.83. ha) y volumen Potencial de Agua Almacenada (VPAA) a 2 m de profundidad es 96, 347.11 m3 en total. También, se evidenció que la zona saturada presenta mayor contenido de carbono (354.02 tC) y para agua la zona húmeda (39,468.51 m3). Nuestros resultados son un aporte relevante para impulsar el manejo y conservación de estos ecosistemas debido a su importancia en el almacenamiento de agua, carbono y bienestar de la población.
Frecuencia de enfermedad arterial periférica y calcificación arterial según la prueba índice tobillo-brazo en pacientes con diabetes mellitus tipo 2 de un hospital público peruano
Authors:   , Espinoza Enciso Luis Fernando , Hernandez Gozar Ivan Gonzalo , Zuñiga Baldarrago Kevin Clared
Published: February 2025

"Objetivo: Determinar la frecuencia de enfermedad arterial periférica (EAP) y calcificación arterial (CA) mediante el Índice tobillo-brazo (ITB) en pacientes con diabetes mellitus.
Metodología: Estudio transversal descriptivo de la data del Programa de Pie en Riesgo del área de Endocrinología del Hospital María Auxiliadora del 2015 al 2020. Calculamos el ITB de cada extremidad inferior usando la presión sistólica más baja, la más alta o la promedio entre la arteria pedía o tibial posterior.1 ipsilateral. Definimos EAP si algún ITB de cualquiera de las dos piernas fue <0.9; CA si el ITB era >1.3; y el resto fue catalogado como normal. Calculamos la prevalencia de EAP y CA por cada método del ITB y evaluamos diferencias entre las categorías del ITB según variables clínicas mediante la prueba de chi cuadrado o F de Fisher.
Resultados: Incluimos a 643 sujetos con una edad media de 61.4 años, 69.8% mujeres. La prevalencia de EAP fue del 7.8%, 15.4% y 28.2% usando como numerador en el ITB la presión sistólica más alta, el promedio o la más baja, respectivamente. La mayor prevalencia de EAP, se presentó con la presión más baja y la menor, con la presión más alta. La CA se observó en el 18.2%, 11% y 16.2% y los normales en el 74%, 73.6% y 55.7%. En los tres métodos, la EAP se asoció a mayor edad y la CA se asoció con mayor tiempo de diabetes.
Conclusiones: Encontramos un rango amplio en la frecuencia de EAP según el método utilizado y un rango estrecho para CA. En EAP, el umbral más alto estaría dirigido para determinar severidad y la presión más baja se recomendaría para estratificar..."
Susceptibilidad genética en población adulta sana para el contagio del SARSCoV-2: revisión sistemática
Authors:   , Llanos Ponce Franco Sebastian , Morelli Olivos Italo Danilo
Published: February 2025

Introducción: La pandemia por la COVID-19 inició a fines de 2019 y se extendió hasta el 2023, reportándose 228 millones de casos positivos a nivel mundial y aproximadamente 5 millones de muertes por dicho virus. Estudios previos mencionan la relación entre polimorfismos genéticos y la susceptibilidad al contagio de la COVID-19, siendo el gen ACE2, uno de los más reconocidos entre estos, y determinante para la entrada del virus al huésped.
Objetivo: Identificar aquellas variantes genéticas influyentes en la susceptibilidad de desarrollar la COVID-19 en población adulta sana.
Diseño: Revisión sistemática
Métodos: Se realizó la búsqueda bibiliográfica en EMBASE, Pubmed, SCIELO y Web Of Science, de estudios tipo casos y controles donde se describan variantes polimorficas implicadas en la susceptibilidad y/o severidad de la infección por la COVID-19 en población adulta sana, publicados entre los años 2019 a 2022. Dichas publicaciones fueron revisadas por los tres investigadores. La Escala NewCastle Otawa fue usada como método de evaluación de la calidad de cada artículo
Resultados: Se obtuvieron 56 variantes genéticas relacionadas tanto en la susceptibilidad como en la severidad para el contagio del SARS-CoV2. Ademas, se halló relación entre alguna de ellas.
Conclusión: Existen polimorfismos que incluyen en el desarrollo y contagio de SARS-Cov2, debido a que influyen en la respuesta inmune frente al virus. Además, se encontró diferentes variantes genéticas en un mismo gen como en el caso del LZTFL1, TMPRSS2, TLR7, ERAP1, ANKRD27, CCR5, IL37, OAS1 y TMPRSS2/MX1.
Presencia de multimorbilidad y su relación con la salud mental en una población adulta peruana
Authors:   , Costa Berlanga Flavio Cesar , Angulo Ramirez Alejandro Marcelo
Published: February 2025

Objetivo:
Evaluar la asociación existente entre multimorbilidad y salud mental en personas adultas entre 30 a 69 años.

Materiales y Métodos:
Análisis de datos secundarios de un estudio de tipo poblacional que fue hecho en la zona periurbana de Tumbes, norte del Perú. Las variables dependientes fueron: síntomas depresivos, evaluados usando el PHQ-9; síntomas de ansiedad, usando la escala de Goldberg; y estrés percibido, evaluado usando la escala de 14 preguntas de Cohen; mientras que la exposición fue la presencia de multimorbilidad (presencia de 2+ condiciones crónicas y número de condiciones crónicas). Las asociaciones se evaluaron usando modelos regresión de Poisson crudos y ajustados.

Resultados:
Se analizó los datos de 1600 participantes, edad media de 48,1 (DE: 10,5) años, y 50,4% fueron mujeres. La prevalencia de multimorbilidad fue de 15,9%, y un total de 23,3% presentaban síntomas depresivos, 42,0% síntomas de ansiedad y 31,4% estrés percibido. En modelo multivariable, la presencia de multimorbilidad se asoció a mayor prevalencia de sintomatología depresiva (61%, IC 95%: 32% - 98%), síntomas
de ansiedad (46%, IC 95%: 28% - 66%) y niveles altos (22%, IC 95%: 14% – 33%), pero no moderados de estrés percibido (6%; IC 95%: 0% – 12%). Un número mayor de enfermedades crónicas estuvo asociada a mayor prevalencia de síntomas depresivos, síntomas de ansiedad y niveles altos de estrés percibido.

Conclusiones:
Presentar multimorbilidad está asociado a una mayor prevalencia de sintomatología depresiva, de ansiedad y niveles de estrés percibido. Nuestros resultados sugieren un manejo adecuado de la salud mental en pacientes con multimorbilidad.
Experiencias vividas sobre el trabajo híbrido y sus repercusiones en la salud mental en trabajadores de una empresa de entretenimiento durante el COVID-19
Authors:   , Ocharan Angulo Sol Maria , Moran Reategui Lizcef Paola
Published: February 2025

Antecedentes: La incorporación obligatoria del trabajo remoto o híbrido, en la pandemia por COVID-19, afectó la salud mental, requiriendo atención y estrategias de afrontamiento. Estudios recientes muestran que esta modalidad de trabajo persiste. Objetivos: Se planteó conocer y comprender las experiencias vividas sobre el trabajo híbrido y sus repercusiones en la salud mental. Método: Se empleó una metodología cualitativa con diseño exploratorio, en la que participaron 10 trabajadores de una empresa de entretenimiento en Perú. Los participantes respondieron a una entrevista semiestructurada basada en temas utilizados para codificar y categorizar las respuestas. Resultados: Los trabajadores percibieron positivamente las acciones de la empresa, pero criticaron al sector público. Surgieron consecuencias psicosociales y estrategias de afrontamiento para manejar el estrés. Discusión: Del análisis temático, y la formulación de supuestos, se contrasta las vivencias de los trabajadores, identificando que estos reconocen como positiva la salud mental en el trabajo. Sin embargo, el trabajo a distancia perjudicó la salud mental debido a la normalización de jornadas laborales extendidas y la suspensión de necesidades sociales como el vínculo familiar y el desarrollo profesional individual.
Factores que influyen en la implementación de servicios de telesalud en Latinoamérica y el Caribe: una revisión realista
Authors:   , Salazar Ochoa Nataly Eva , Cruz Fuenzalida Sebastian
Published: February 2025

En el presente estudio se investiga la eficacia de las intervenciones de telesalud en América Latina y el Caribe, así como los factores que influyen en su implementación. Se realizó una revisión realista, analizando sistemáticamente 33 artículos publicados entre 2012 y 2024 sobre intervenciones de telesalud y telemedicina en Latinoamérica y el Caribe. Se empleó un enfoque de análisis temático para identificar los mecanismos clave y los factores contextuales que moldean los outcomes. Los hallazgos indican que las intervenciones de telesalud, conllevan a una reducción de los tiempos de espera, una mejora de los parámetros clínicos, un aumento de la calidad de vida, mejora en la accesibilidad y una mejor adherencia al tratamiento. Se propone que la capacitación adecuada del usuario, percepción positiva del usuario y prestación de atención integral y sincrónica es necesario para una correcta implementación de intervenciones de telesalud, en especial en el contexto Latinoamericano y el Caribe. Brindar capacitación oportuna tanto a los pacientes como a los proveedores garantiza un uso seguro y eficaz de la tecnología. Igualmente, importante es abordar las preocupaciones de los usuarios y demostrar el valor de la telesalud para fomentar percepciones positivas y fomentar la adopción. Finalmente, la integración de la comunicación sincrónica y la atención coordinada dentro de las intervenciones de telesalud conduce a una mejor adherencia del paciente y mejores resultados en el tratamiento. Se advierte contra la generalización de estos resultados debido a los factores contextuales en toda la región y requieren de un análisis individual y multifactorial...
Isolating the Primary Drivers of Fire Risk to Structures in WUI regions in California
Authors: Gollner Michael , Zamanialaei Maryam , Martin Daniel San , Theodori Maria , Purnomo Dwi , Tohidi Ali , Lautenberger Chris , Trouve Arnaud , Qin Yiren
Published: February 2025

The destructive impacts of Wildland-Urban Interface (WUI) fires on people, property and the environment have dramatically increased, especially in California. Critical factors influencing structure protection during wildfires, including home hardening (e.g., vents, siding, roof, eaves, window, construction year), defensible space (vegetation and surrounding features), exposure to flames and embers, and structure separation are well known but their interrelated impacts are not quantified. Here, we find that structure separation and exposure significantly influence the probability of loss, underscoring the role of large conflagrations in driving widespread destruction. Machine learning models combined with previously unavailable exposure data enhance the predictive accuracy of structure loss up to 82%. Home hardening and defensible space, especially closest to the home, are still vital and effective mitigation measures, cutting hypothetical structures losses by 52%. Our results offer data-driven actionable insights for prioritizing mitigation strategies to protect vulnerable communities and structures in the WUI.