bluuebunny/crossref_metadata_2025 huggingface dataset:
Notary Responsibility for Unlawfully Made Deeds in Legal Deeds of Buying and Selling Land
Authors: Ali Mahdafi Rafki , Sudiro Amad
Published: December 2023

This research discusses legal protection for buyers who have good intentions in land buying and selling transactions based on Supreme Court Decision Number 20 PK/Pid/2020. The research method used is normative juridical research with a case approach. The data used is secondary data originating from primary, secondary and tertiary legal materials. In discussions regarding sale and purchase deeds, sale and purchase agreement deeds, or power of attorney deeds to sell, it is important to apply the principle of good faith to create a sense of mutual trust between the seller and the buyer. Good faith in an objective sense means that the agreement must be implemented by complying with the norms of propriety and decency so as not to harm either party
The Effect of Capital Structure and Company Growth on Company Value Through Profitability as an Intervening Variable
Authors: Paul Erikson Riba Yohanes
Published: December 2023

The purpose of this study is to determine the effect of capital structure and company growth on firm value through profitability as variable intervening in consumer goods manufacturing companies listed on the Indonesia Stock Exchange. The method used in this study is descriptive and associative method through a quantitative approach and the data analysis method used is descriptive statistical analysis, classical assumption test, multiple regression analysis and path analysis (path analysis). The population of this research is consumer goods companies listed on the Indonesia Stock Exchange in 2019-2021. The sample is determined based on the method purposive sampling, with a total sample of 47 companies. The data used in this research is secondary data. The data collection method in this research is document study. Based on the results of the tests conducted, it shows that (1) capital structure has no positive effect on firm value, (2) company growth has no positive effect on firm value, (3) capital structure has a positive effect on profitability, (4) company growth has a positive effect on profitability , (5) profitability has a positive effect on firm value, (6) capital structure has a positive effect on firm value through profitability while company growth has no positive effect on firm value through profitability
Exploring medical mistrust: from clinic to community
Authors: Schmidt-Sane Megan , Storer Elizabeth , Ripoll Santiago , Hrynick Tabitha
Published: December 2023

This introduction to the special issue, Exploring Medical Mistrust: From Clinic to Community, provides a conceptual framing of ‘medical mistrust’ from a critical social science lens. This special issue explores and unpacks the complex temporal, social and scalar relationships which are intertwined with contemporary manifestations of mistrust in medicine. We ask what social science and humanities disciplines can offer in relation to wider understandings of the processes driving resistance to and refusal of medical interventions, including but also beyond vaccines. We distil insights derived from diverse spaces of medical encounter, ambivalence and resistance that serve as arenas which generate mistrust. We bring this analysis to deepen an understanding of the frictions and affective relations which exist between vertical and horizontal relations which constitute health systems.
Analisis Pengelolaan Kegiatan Ekstrakurikuler di MAN 2 Padang Pariaman
Authors: Syaiful Aisyah Fitra Azira , Sufyarma Marsidin
Published: December 2023

Petelitian ini dilatar belakangi oleh kegiatan ekstrakurikuler kurang dikelola secara baik oleh pihak sekolah. Tujuan dalam penelitian ini adalah untuk menganalisis pengelolaan kegiatan ekstrakurikuler di MAN 2 Padang Pariaman.

Jenis penelitian ini adalah penelitian pendekatan deskriptif dengan metode kualitatif. Penelitian deskriptif ini bertujuan untuk mendeskripsikan hasil penelitian. Untuk teknik pengumpulan data dalam penelitian ini terdiri dari 3 yaitu observasi, wawancara dan dokumentasi. Sedangkan teknik analisis data yang digunakan adalah reduksi data, penyajian data, verifikasi data.

Hasil penelitian ini menyimpulkan sebagai berikut; (1) Pengelolaan kegiatan ekstrakurikuler di MAN 2 Padang Pariaman, masih terdapat permasalahan dalam perencanaan yaitu kurangnya perencanaan sarana dan prasarana kegiatan ekstrakurikuler, kurangnya perencanaan dana BOS dan kurangnya minat siswa. (2) Pengelolaan kegiatan ekstrakurikuler di MAN 2 Padang Pariaman melalui pengorganisasian kurangnya tanggung jawab tim dalam melaksanakan kegiatan ektrakurikuler di MAN 2 Padang Pariaman. (3) Pengelolaan kegiatan ekstrakurikuler di MAN 2 Padang Pariaman melalui pelaksanaan kurangnya sarana dan prasarana seperti pianika dan Qur’an. Kurangnya anggaran dana bos dan partisipasi dan minat siswa. (4) Pengelolaan kegiatan ekstrakurikuler di MAN 2 Padang Pariaman melalui evaluasi masih kurangnya kriteria evaluasi yang jelas dalam kegiatan ekstrakurikuler di MAN 2 Padang Pariaman.
Persepsi Guru Terhadap Kegiatan Supervisi Akademik Oleh Kepala Sekolah Di SMA Negeri Se Kecamatan Pasaman Kabupaten Pasaman Barat
Authors: Tika  , Adi Nelfia , Anisah  , Alkadri Hanif
Published: December 2023

Penelitian ini bertujuan untuk memperoleh informasi mengenai persepsi guru terhadap kegiatan perencanaan, pelaksanaan, penilaian dan umpan balik supervisi akademik oleh kepala sekolah di SMA Negeri di Kecamatan Pasaman Kabupaten Pasaman Barat. Penelitian yang dilakukan adalah jenis penelitian kuantitatif dan deskriptif. Seluruh pengajar di SMA N 1 dan SMA N 2 Pasaman menjadi populasi penelitian ini yaitu 107 guru, dan sampelnya adalah 50 guru (SMA N 1) dan 57 guru (SMA N 2) dengan menggunakan metode proporsional random sampling. Penelitian ini menggunakan kuesioner skala Likert yang telah melalui penelitian untuk memastikan validitas dan reliabilitasnya. Pendekatan analisis statistik deskriptif digunakan untuk analisis data penelitian ini. Hasil penelitian ini adalah 1) perencanaan memperoleh 4,45 dengan kategori baik, 2) pelaksanaan memperoleh 4,56 dengan kategori baik, 3) penilaian memperoleh 4,6 dengan kategori sangat baik, dan 4) umpan balik memperoleh 4, 31 dalam kategori baik.
Iklim Organisasi di Dinas Pendidikan dan Kebudayaan Kabupaten Pasaman Barat
Authors: Susanti Lusi , Lara maisiska  , Sabandi Ahmad , Ningrum Tia Ayu
Published: December 2023

This study aims to obtain information about the organisational climate in the education office and West Pasaman district seen from indicators of warmth, innovation, cooperation, openness, support and responsibility in the West Pasaman District Education and Culture Office. This type of research is descriptive research. The research population was all employees at the West Pasaman Regency Education and Culture Office, totaling 72 people. Determination of the magnitude is determined by the Slovin formula, withdrawal using saturated sampling technique. The instrument used was a questionnaire with a Likert scale and tested its validity and reliability. Furthermore, the data collected is analysed by finding the average and categorising the level of achievement. The results showed that organisational climate was seen 1) warmth 4.3, 2) innovation 4.3, 3) collaboration 4.4, 4) openness 4.4 5) support 4.3 and 6) responsibility 4.3. So the organisational climate in the Pasaman Barat district education office is included in the conducive category with an average score of 4.4..
Motherhood in Female Same-Sex Couples: Reception of Oocytes from Partner (ROPA method): Review Article
Authors: Martínez Ruiz Abraham
Published: December 2023

The evolving concept of "family" reflects contemporary social changes, influenced by historical and cultural shifts. This review explores unconventional family models, focusing on same-sex families, particularly female same-sex couples. As advancements in assisted reproductive techniques (ART) empower these couples, the Reception of Oocytes from Partner (ROPA) method gains popularity. ROPA involves active participation of both partners in conception, with one as the oocyte provider and the other as the gestational mother. This review delves into clinical, ethical, and psychosocial aspects of ROPA, comparing it with other ART options like donor intrauterine insemination (DIUI) or in vitro fertilization (IVF). A comprehensive bibliographic search conducted in 2023 forms the basis of this exploration. Historical perspectives on ART's acceptance for same-sex couples, legislative changes, and global variations in donor anonymity are discussed. The ROPA method's procedural details, including donor selection and the roles of the genetic and gestational mothers, are outlined. The review also emphasizes the impact of donor anonymity laws on decision-making. Roles and responsibilities in the ROPA method are explored, with a focus on the reciprocal and reverse ROPA approaches. Medical indications, potential benefits, and the impact on obstetric risks are scrutinized. The review concludes with insights into motherhood in female same-sex couples, highlighting the prevalence of children raised in such families across diverse regions in the United States. This comprehensive examination aims to provide practitioners and patients with valuable insights into the clinical, ethical, and psychosocial dimensions of the ROPA method, fostering a better understanding of its advantages in comparison to other ART options.
Vacinar ou não vacinar? Análise da jurisprudência do Supremo Tribunal Federal
Authors: Kölling Gabrielle
Published: December 2023

A sociedade atual está sendo testada cotidianamente em função da pandemia COVID19, a saúde já não tem mais fronteiras e o Estado tem sido cada vez mais demandado. É nesse cenário que se faz necessária a releitura da atuação estatal no que tange às medidas de enfrentamento à pandemia. Uma das medidas é a vacinação. O tema das vacinas envolve tanto o fomento à ciência para a produção de respostas vacinais quanto a compra/produção, bem como a política pública de vacinação. Assim, a análise de jurisprudência pretende observar o posicionamento do Supremo Tribunal Federal (STF) acerca do tema da vacinação ser obrigatória ou não. O método empregado é o hipotético-dedutivo e as técnicas são a análise documental, a jurisprudencial e a bibliográfica.
Deslocados ambientais
Authors: Torossian Sueli , Kölling Gabrielle , Bertolini Letícia Macena , Nascimento Lídia Iida
Published: December 2023

Com uma maior ocorrência dos desastres ambientais, visa-se mostrar a realidade do direito à moradia e a sua relação com o Estado Ambiental, demonstrando a importância dos direitos dos desastres e o seu aperfeiçoamento.
Growth and value distribution of linear difference polynomials generated by meromorphic solutions of higher-order linear difference equations
Authors: Luo Yi Xin , Zheng Xiu Min
Published: December 2023

In this article, we investigate the relationship between growth and value distribution of meromorphic solutions for the higher-order complex linear difference equations $$ A_n(z)f(z+n)+\dots+A_1(z)f(z+1)+A_0(z)f(z)=0 \quad \text{and } =F(z), $$ and for the linear difference polynomial $$ g(z)=\alpha_n(z)f(z+n)+\dots+\alpha_1(z)f(z+1)+\alpha_0(z)f(z) $$ generated by \(f(z)\) where \(A_j(z)\), \(\alpha_j(z)\) (\(j=0,1,\ldots,n\)), \(F(z)\) \((\not\equiv0)\) are meromorphic functions. We improve some previous results due to Belaidi, Chen and Zheng and others.

For more information see https://ejde.math.txstate.edu/Volumes/2023/84/abstr.html
How Silence Contributes to the Performance of Sincerity in Psychotherapy
Authors: Berger Israel , Rae John P.
Published: December 2023

Most literature concerning silence in psychotherapy has focused on the meaning of silences, particularly from psychoanalytic perspectives, and is based on clinical experience rather than empirical studies. These authors tend to interpret silence as pathology or resistance in the client and/or advise clinicians to be especially tolerant of silence and to avoid filling silences. Although some studies have found that moderate silence is correlated with better outcomes, these studies ignore psychosocial aspects of the interaction. No research has looked at silence in psychotherapy as a linguistic device to manage the local sequential environment. Silence following an initiating action is characteristic of dispreferred responses such as refusals and negatively valenced answers in general conversation. In this study, we used conversation analysis to explore preference and the role of silence in nine spiritually oriented humanistic psychotherapy sessions. We found that in contrast to everyday conversation, in these interactions, there is a preference for gaps and pauses while immediate responses are dispreferred.
Model analize detekcijsko-reakcijskih kapaciteta granične policije
Authors: Vrđuka Anđelko
Published: December 2023

Zaštita državne granice složen je proces koji ovisi o nekoliko elemenata. Definiranost granične crte preduvjet je bilo kakvih aktivnosti granične policije. Utvrđivanje linije detekcije nužno je za definiranje tehničkih potreba granične policije, a linija reakcije osnova je za definiranje infrastrukturnih projekata koje je potrebno provesti. U prvom dijelu članka iznose se smjernice za lakše definiranje protezanja granične crte te se razrađuju pojmovi linije detekcije i linije reakcije. Posebno se objašnjavaju procedure za povećanje područja detekcije i za skraćivanje vremena reakcije. Sukladno s razrađenim elementima nužnim za zaštitu državne granice, u drugom dijelu članka, na primjeru Postaje granične policije Gvozd, predstavljen je model analize detekcijsko-reakcijskih kapaciteta granične policije. Na temelju navedenog modela izračunat je broj policijskih službenika potrebnih za zaštitu državne granice u spomenutoj postaji.
Еда для голоса
Authors: Елисеева Татьяна  , Ткачева Наталья
Published: December 2023

Знаете ли Вы о том, что красивый голос, подаренный Вам природой, требует ухода и заботы? Причем заключаются они не только в предупреждении и лечении заболеваний горла и голосовых связок, но и в обеспечении правильного питания, особенно если вы занимаетесь пением или часто провозглашаете речи перед огромной аудиторией. О том, каким оно должно быть, и пишут известные физиологи и диетологи.

HTML версия статьи
KDIGO 2021 Blood Pressure Target Update and Chronic Kidney Disease Progression
Authors: Jifei Guo , Xi Yinliang
Published: December 2023

In 2021, Kidney Disease: Improving Global Outcomes (KDIGO) published revised guidelines, including updated recommendations for the management of chronic renal disease and the control of blood pressure. The 2021 KDIGO Guidelines utilize current research and comprehensive scientific evidence to provide the most favorable blood pressure goals for those suffering from chronic kidney disease. The primary objective is to decelerate the advancement of renal impairment, mitigate problems linked to chronic kidney disease, and enhance the patient's quality of life. The 2021 KDIGO guidelines ground the blood pressure target recommendations for patients with chronic kidney disease (CKD) in a thorough evaluation of the extent of kidney damage, cardiovascular risk, and individual patient characteristics. The 2021 KDIGO guidelines recommend tailoring blood pressure control in patients with CKD to each individual rather than following a standardized method.
Evaluation of Formulated Feed of Plant and Animal Origin on the Growth Performance of O. Niloticus in Ponds, Ethiopia
Authors: Oumer Mohammed
Published: December 2023

This study was conducted to evaluate the effect of supplementary feeding on the growth of Oreochromis niloticus in concrete ponds. Two formulated feeds, one  with only plant material origin (Noug  cake,  Brewery  waste & wheat  bran)  and  another mix ofplant and  animal origin (Fish meal, Brewery waste and  wheat  bran) with  similar  protein  content  were   used.  The   feeding  trial   was conducted in  six  concrete ponds of about  50  m2   each. The  control and  experimental groups were  run in duplicate with stocking density of  2  fish/m2.  The  treatment groups  were  fed  at  5%  of  their  body weight with the  respective test feeds and  the  control group  was left without  any   supplementary  feed.  The   results  of  the   experiment showed  that   fish   given   supplemental   diets   grew   much   faster (ANOVA, P<0.05)   than  the  control  group.   Although  no  significant growth  differences were  observed between the  test feeds (ANOVA, p=0.42),  fish raised in mixture of plant and  animal origin (0.35 g/day) showed better  growth  rate  than  plant  origin.  Differences  in  growth rates between the  control  and  test feeds  as well  as among the  test feeds  can   be   attributed   to   both   direct   and   indirect   effects  of supplementary feeds  given  to the  fish.  Direct  intake  of feeds  by the fish   provides   more    nutrients   resulting   in   better    growth    and production.  Therefore,  all  supplementary  feeds  have  an  impact  on the growth of O. niloticus in ponds
Bio-Ethanol Production from Wheat Straw Using Yeast Isolates
Authors: Wondaferew Mesfin , Tesfaw Asmamaw
Published: December 2023

In the first hand, the cost of fossil fuel is increasing alarmingly. On the second hand, combustion of fossil fuels contributes for global warming. Therefore, it need to strength the production of renewable energies. The aim of this study was to produce bioethanol from wheat straw using yeast isolates. The isolates were isolated from decomposed soil, termite soil and rotten wood samples using yeast extract peptone dextrose media (YPD) and characterized chemically and morphologically. The wheat straws were powdered and hydrolyzed with dilute sulfuric acids. After neutralization, it was used to produce ethanol. Response surface methodology was employed to optimize the ethanol production process from wheat straws. The isolates were grown optimally at a temperature of 30oC, pH nearly 5, and sugar concentration 70 to 120 g/L.  Among hydrolysis conditions, lower acid concentration (less than 1.5%) and temperature of 60oC resulted higher reducing sugars. The optimization study showed that the highest bio-ethanol concentration of 6.8g/l was observed by SWX under the optimum conditions of with 1% H2S04, 60oC temperature and 52.5-minute time hydrolysis at 30°C for 48 hour incubation time. Wheat straws could be good candidate for ethanol production.
Pemberdayaan Kelompok Wanita Tani (KWT) Tunas Berkah Kota Blitar dengan Metode Parcipatory Rural Appraisal
Authors: Puspitorini Palupi , Purwatiningsih Rini , Sunandes Aris
Published: December 2023

Community empowerment is a way to increase and strengthen community skills to participate in development which is carried out energetically. The expected result is that the community can resolve the problems experienced in a more flexible (independent) and self-sufficient way. The community empowerment approach that is realized in development in a participatory manner (Participatory Rural Appraissal) is very suitable for business groups so that they can then overcome problems that arise. in group activities. The partner of this service is the Tunas Berkah Women's Farmers Group which operates in the field of vegetable plant breeding, which is domiciled in RW 04 Gedog Village, Sananwetan District, Blitar City. Service Objectives: to form partners who are more productive and have a high entrepreneurial spirit and values, to improve students' experience of studying outside campus as one of the implementations of MBKM. Implementation of activities includes program planning, administrative preparation and team coordination, Continuous assistance from pre-production to post-production, Activity Evaluation and Control. The results of the activities achieved are Overcoming seed production problems, overcoming business management and human resource problems, Overcoming seed marketing problems. Using the PRA method, FGD activities, PRA training/socialization, nursery cultivation training, nursery business management training, and marketing have been carried out which can increase the capacity of groups with larger business scales that have an organizational and economic impact.
Análisis del Discurso en Redes Sociales relacionado con las Conductas Suicidas: Estudio Comparativo entre Adolescentes Italianos y Españoles
Authors: Sisto María , Simón Márquez María Del Mar , Martos Martínez África
Published: December 2023

Los estudios sobre suicidio e Internet surgieron hace solo una década y aquellos sobre conductas suicidas y redes sociales son aún más recientes. Hasta la fecha, todos los beneficios y daños relativos al uso de las redes sociales y conductas suicidas en la adolescencia no se conocen del todo. No obstante, la presencia imperante de las redes sociales en la vida juvenil está fomentando el desarrollo de estrategias basadas en su uso, para la intervención, detección y prevención del suicidio. La presentación online de comportamientos suicidas es una muestra de la trascendencia del fenómeno y de la necesidad de abordarlo, teniendo en cuenta que en la literatura científica es escaso el análisis de la relación entre suicidio y redes sociales. Por ello, es necesario explorar todas las posibilidades ofrecidas por las redes sociales para detectar los factores implicados en estas conductas. El presente trabajo consiste en un análisis exploratorio del discurso social en Twitter sobre la base de tres categorías asociadas a las conductas suicidas, con fines descriptivos, preventivos, y comparativos, entre dos muestras de adolescentes: italianos y españoles. Los resultados extraídos evidencian un mayor número de tweets tanto pro-suicidas como instigadores en la muestra italiana, en comparación con la española, mientras que la muestra española supera a la italiana en cuanto a los tweets anti-suicidio. Se sugiere profundizar en las respuestas útiles a las comunicaciones en línea de los adolescentes y en otras posibilidades brindadas por las plataformas de redes sociales en el análisis del suicidio juvenil.
Estilo de vida saludable en la adolescencia: Relación con autoestima y diferencias según sexo
Authors: González Moreno Alba , Molero Jurado María Del Mar
Published: December 2023

La adolescencia es un periodo crucial en la vida de los jóvenes donde se experimentan ciertos comportamientos que pueden tener cierta repercusión en la vida adulta. El objetivo de este estudio fue identificar las relaciones existentes entre un estilo de vida saludable y la autoestima en estudiantes adolescentes, así como, comprobar si existen diferencias según el sexo. Este estudio descriptivo y transversal ha contado con la participación de un total de 743 estudiantes de entre 14 a 19 años de distintos centros educativos de la provincia de Almería (España). Los instrumentos utilizados para la recogida de datos fueron el Cuestionario de Estilos de Vida Saludables (CEVS-II) y la Escala de Autoestima de Rosenberg (RSES). Los resultados obtenidos destacan la asociación positiva entre autoestima y hábitos positivos como dieta sana, sin embargo, la relación ha sido negativa con las dimensiones asociadas con el consumo. Se han encontrado diferencias según el sexo, destacando los chicos en dieta sana, respeto en los horarios de comidas, hábitos de descanso, actividad física y autoestima; mientras que las chicas puntúan más en consumo de alcohol. Se debate la necesidad de promover hábitos de vida saludables en la adolescencia para potenciar el bienestar personal de los jóvenes.
Programa de intervención en violencia filioparental basado en la Terapia de Aceptación y Compromiso
Authors: Marquinez-Rengifo José-Manuel , Fernández-Muñoz Juan José , Fernández-Martínez Elia
Published: December 2023

La violencia filioparental (VFP) es un problema social con consecuencias importantes para la salud mental de los que la sufren. El incremento de las investigaciones sobre la VFP se ha visto respaldada por el aumento del número de casos informados y la gravedad de sus consecuencias. El objetivo de esta investigación es analizar si la aplicación de un programa de intervención basado en la terapia de aceptación y compromiso (ACT) modifica la tolerancia a la frustración, la autoestima, la autoeficacia, la inteligencia emocional, la depresión y la ansiedad de los adolescentes. Los participantes fueron 231 individuos que se reclutaron en un centro especializado en adolescentes que ejercen VFP. Se estableció un grupo de intervención en terapia de aceptación y compromiso (ACT) y un grupo control, midiendo las variables antes de la intervención, y a los 3 meses. Los resultados nos sugieren la idoneidad de incluir intervenciones de ACT en el tratamiento de la VFP, pero se necesita más investigación e intervenciones con los adolescentes y sus familias para ayudarles a volver a retomar el control de sus vidas
Contribución de la pasión y la procrastinación académica multidimensional sobre el burnout en el ámbito universitario a distancia
Authors: González-Brignardello Marcela Paz , Sánchez-Elvira Paniagua Ángeles
Published: December 2023

El presente estudio tiene como propósito examinar la capacidad predictiva que la pasión por los estudios y la procrastinación académica multidimensional tienen sobre el burnout. La muestra incluyó a 1648 estudiantes de primera matrícula en la Universidad Nacional de Educación a Distancia. Se realizaron análisis de regresión jerárquica en dos bloques. Los resultados revelan que ambos procesos psicológicos influyen en el burnout, pero de manera diferenciada. La pasión, particularmente la armoniosa, actúa como factor protector, mientras que la obsesiva tiene un efecto levemente perjudicial en todas las dimensiones del burnout. La introducción de las dimensiones de la procrastinación académica mejora significativamente la capacidad predictive del modelo: la procrastinación central y la desconexión del trabajo son predictores positivos del burnout, mientras que la pobre gestión del tiempo tiene un efecto inverso en relación con el cinismo, funcionando como protector ante el desapego y la desvalorización del estudio. Este estudio sugiere nuevas líneas de investigación que permitan abordar debates sin resolver sobre la procrastinación académica y conocer su impacto en el bienestar, el rendimiento y el abandono estudiantil.
Challenges Of Eradication Poliomyelitis In Borno State, Nigeria
Authors: Ijiekhaumhen Kingsley Philip
Published: December 2023

Fighting poliomyelitis in a challenging environment has to overcome many hurdles. The study centered on fighting poliomyelitis in a challenging environment. Both qualitative and quantitative research were used, the research design used in this study was descriptive survey. Data was collected using a semi-structured questionnaire. The target population was 148 respondents. The sample size for the study comprises of 145. Based on the findings and analysis, it could be concluded that, It may be difficult for polio to be eradicated in Borno state, nigeria, due to persistent insurgency in the local government areas and the impact on health, infrastructure and socioeconomic situation of the populace. Urgent attention is required. The government should intensify efforts in curbing the spate of attacks and insecurities and complete restoration of peace and tranquility to the affected communities and states.
Sexagésimo Aniversario Promoción “Bicentenario de Estudio Médicos”
Authors: Garces Maria Fátima
Published: December 2023

Quiero iniciar estas breves pero afectuosas palabras recordando al gran médico griego Hipócrates, quien nos ilustra suficientemente al afirmar: “Donde quiera que se ama el arte de la Medicina se ama también a la humanidad” Y es que celebrar sesenta años de graduación, de tránsito comprometido por los densos caminos de la ciencia médica es el ejemplo más significativo de un convencimiento inmarcesible de que amar tan desprendida profesión y ejercerla con entusiasmo, mística y responsabilidad es también profesar amor al prójimo, amor al país, amor a la humanidad.
Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer
Authors:   Cancer biology research center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, P.R. China, Ma Ding , Wang Shixuan , Zhou Jianfeng , Wei Juncheng , Wang Beibei , Wu Peng , Song Xiaohong , Weng Danhui , Xi Ling ,   Cancer biology research center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, P.R. China, Shi Xiaoyan ,   Department of Oncology, Renmin Hospital, Yunyan Medical College, 23 Chaoyang road Shiyan, Hubei, P.R. China
Published: December 2023

To investigate the roles of VEGF-C, VEGFR-3 and cyclooxygenase-2 (COX-2) in tumor progression and lymph node metastasis. The expression of VEGF-C, VEGFR-3 and COX-2 were examined in 93 cases of surgical speciments of cervical diseases by immunohistochemical staining. The correlation between expression of these factors and tumor aggressiveness was evaluated. The expression levels of VEGF-C and COX-2 were much higher in cervical cancer than in cervical intraepithelial neoplasia (CIN) and in chronic cervicitis. VEGF-C expression correlated with lymph node metastases (P<0.01). Multivariate analysis indicated that lymph vessel density (LVD) was associated with the coexpression of VEGF-C and COX-2. Expression of VEGF-C and VEGFR-3 were both in coincidence with lymph node metastasis. VEGF-C and COX-2 may promote the canceration of cervical cancer and that VEGF-C/ VEGFR-3 system had a significant association with the lymphagiogenesis and lymph node metastasis.
Spectrofluorimetric Determination of Labetalol Hydrochloride in Pharmaceutical Preparations and Urine Samples
Authors:   Department of Chemistry, Aligarh Muslim University, Aligarh-202002 (U.P.), India, Rahman Nafisur
Published: December 2023

Two simple and sensitive spectrofluorimetric methods have been developed for the determination of labetalol (LBT). In method A, the native fluorescence was measured at 432 nm after excitation at 312 nm. The second method (method B) is based on the formation of a ternary complex between zinc (II), eosin and LBT. The fluorescence intensity of the ternary complex was measured at 452 nm after excitation at 317 nm. Optimum conditions for the determination were also investigated. The linear range and detection limit for method A and B were found to be 1.25-30 µg/ml; 0.24 µg/ml and 0.5-4 µg/ml; 0.08 µg/ml, respectively. The proposed methods are simple, practical and relatively free of interference from coexisting substances. The methods have been applied to assess LBT in commercial tablets and human urine samples with good precision and accuracy.
Novel Spectrophotometric Method for the Assay of Captopril in Dosage Forms using 2,6-Dichloroquinone-4-Chlorimide
Authors:   Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt, El-Enany Nahed , Belal Fathalla ,   Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt, Rizk Mohamed ,   Department of Analytical Chemistry, Faculty of Pharmacy, University of Helwan, Cairo, Egypt
Published: December 2023

A simple spectrophotometric method was developed for the determination of captopril (CPL) in pharmaceutical preparations. The method is based on coupling captopril with 2,6-dichloroquinone-4-chlorimide (DCQ) in dimethylsulphoxide. The yellow reaction product was measured at 443 nm. The absorbance -concentration plot was rectilinear over the range of 10-50 µg/mL with minimum detection limit (LOD) of 0.66 µg/mL and a quantification limit (LOQ) of 2.0 µg/mL. The different experimental parameters affecting the development and stability of the color were carefully studied and optimized. The proposed method was successfully applied to the analysis of commercial tablets and the results were in good agreement with those obtained using official and reference spectrophotometric methods. Hydrochlorothiazide which is frequently co-formulated with CPL did not interfere with the assay. A proposal of the reaction pathway was presented.
Detection and Characterization of Nocardia from Patients Diagnosed as Tuberculosis in Egypt
Authors:   Molecular Biology Laboratory, Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut, USA, Khan Mazhar I. , Helal Zeinab H. , El-Din Ashour Mohamed Seif ,   Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt, Eissa Somaia A. ,   Center of Tuberculosis, Department of Microbiology and Immunology, Faculty of Medicine, Cairo University, Cairo, Egypt
Published: December 2023

Pulmonary tuberculosis and pulmonary nocardiosis are similar in most clinical symptoms and radiological manifestation. In the developing countries like Egypt where tuberculosis is very common, anti-tuberculosis drugs are started on basis of radiology and clinical symptoms. This study included 600 sputum specimens collected from 200 patients diagnosed as pulmonary tuberculosis from three chest hospitals in Egypt. IS6110 specific primer were selected for PCR to identify the Mycobacterium tuberculosis and hsp65 gene specific primers were used for PCR and sequencing for the identification of Mycobacterium and Nocardial species. The region of the gene coding for 16S rRNA in Nocardia species were selected as genus specific primer sequences for a PCR and Real Time PCR assays. Our result confirmed that four whole DNA samples, extracted from sputum specimen from the pulmonary tuberculosis patients on anti-tuberculosis treatment, were Nocardia species. Three of them matched (99% homology) with Nocardia farcinica (formerly Nocardia asteroid type V) and one match (83% homology) with Nocardia pneumonia. Molecular methods such as PCR and real-time PCR for identification of Nocardia are rapid and accurate methods. No cross-reactions were observed using Real Time PCR specific for Nocordia with other closely related genera.
Kinetic Spectrophotometric Determination of Biotin in Pharmaceutical Preparations
Authors:   Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt, Salim M. M. , Walash M. I. , Rizk M. , Sheribah Z. A.
Published: December 2023

A simple accurate kinetic spectrophotometric method was developed for the determination of biotin in pure form and pharmaceutical preparations. The proposed method is based on a catalytic acceleration of biotin on the reaction between sodium azide and tri-iodide in an aqueous solution. Concentration range of 4-16 µg/mL for biotin was determined by measuring the decrease in the absorbance of tri-iodide at 348 nm by a fixed time method. The decrease in absorbance after 14 min from the initiation of the reaction was markedly correlated to the concentration with correlation coefficient of 0.9999. The detection limit (LOD) of biotin was 0.18 µg/mL while quantitation limit (LOQ) was 0.54 µg/mL. The percentage recovery of the spiked samples was 100.08 ± 0.761. The proposed procedure was successfully applied for the determination of biotin in its pharmaceutical preparations with mean recoveries of 101.17 ± 2.05 and 97.87 ± 1.50 for biotin ampoules and capsules, respectively. The results obtained were in good agreement with those obtained using official method.
Lower-Dose and Long-Term Intermittent Interferon Therapy for Hepatitis C Genotype 2a may be a Possibility
Authors:   Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, Japan, Araki Yoshio , Tsujikawa Tomoyuki , Fujiyama Yoshihide ,   Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, Japan, Sugihara Hiroyuki , Hattori Takanori ,   Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, Japan
Published: December 2023

We report two recent, successful cases in treating active chronic hepatitis C patients (genotype 2a) with a lower-dose and long-term intermittent interferon therapy. Case 1: A 67-year-old female received IFN-alpha 3 MU twice a week. Biochemical and virological remissions were achieved after 4 weeks and 14 months, respectively. We changed the IFN to pegylated-interferon alpha-2a (P-IFN) 45 μg once a week. After which, we successfully reduced the frequency of injections to once a month while maintaining both remissions. Case 2: A 61-year-old male had received a conventional genetical recombination interferon therapy. However, the hepatitis recurred. He was given IFN-alpha 3 MU once a week. A biochemical remission was achieved after 3 months. After 7 months, we changed the IFN to P-IFN 90 μg once a week, and a virological remission soon occurred. Then, we also could reduce the frequency to once every two months. Our novel strategy using P-IFN is safe and economic.
Impacts of Social Distancing and a Potential Remedy: A Randomized Double-blind Placebo-controlled Study
Authors:   Titus Family Department of Clinical Pharmacy, USC Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, California, United States, Liang Jing , Watanabe Saki , Davies Daryl L. ,   Titus Family Department of Clinical Pharmacy, USC Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, California, United States, Qin Zishu ,   Suzhou Hospital of Traditional Chinese Medicine, Jiangsu, China, Chen Yingqi ,   Beijing Chaoyang Integrative Medicine Rescue and First Aid Hospital, Beijing, China, Wu Jianrong ,   Unionluck BioTech, Beijing, China, Wu Jing , Yu Xiu , Zhang Kaiying , Li Liu ,   Carefree Biotech Co, Beijing, China, Cao Freddy ,   College of health professions and sciences, University of Wisconsin - Milwaukee. United States, Shi Hanping ,   Capital Medical University, Beijing, China
Published: December 2023

Objectives: To gain insight into how social distancing impacts human life and how it may induce stress, anxiety, depressive-symptoms, sleep disturbance, and mental challenges during the pandemic; and to evaluate the effects of a complementary therapy named Smarto-One on improving these health impacts. Methods: Participants, men and women aged 20-65, were randomly assigned to the interventional Smarto-One group (n=259) or placebo group (n=68). Participants orally self-administered Smarto-One or placebo for 20 consecutive days. Online surveys were completed by the participants the day before the 20-day treatment start date and the day following treatment end date. Fifteen participates from Smarto-One group and fifteen participates from placebo group participated in electroencephalography (EEG) during sleep before and after the 20-day intervention. The primary outcome measures were sleep duration and self-evaluated stress. Results: We found 1) during social distancing due to the COVID-19 pandemic, stress/depression led to sleep disturbance and mental issues; 2) participants taking Smarto-One showed significant improvements in stress/depression levels, sleep duration and wake-up mood/symptoms compared to placebo; and 3) participants taking Smarto-One showed significantly improved deep sleep time (slow-wave sleep, SWS, N3) of non-rapid eye movement (non-REM) sleep as measured by EEG. Conclusions: This study illustrates the value of Smarto-One as an effective remedy that improves mental health and well-being under conditions including social distancing and stress/depression.
Analisis Kesejahteraan Karyawan Pada Kantor Pusat Dirjen Jenderal Pajak Jakarta Selatan
Authors: Andre Fuad Gunawan  , Christian Wiradendi Wolor  , Marsofiyati  Marsofiyati
Published: December 2023

Abstract. This research aims to determine the analysis of employee welfare at the Head Office of the Director General of Taxes, South Jakarta. This research uses a descriptive approach, namely by describing and analyzing the problems found. This qualitative research was obtained by observation, interviews and documentation. Meanwhile, secondary data was obtained through books, previous research and articles related to research. From the results of this research, it can be seen that the South Jakarta tax head office has carried out all existing management stages or cycles, but not all welfare in the prosperous life cycle has been well maintained. This can be seen from the extensive work and information system changes carried out by tax office employees.
Wujudkan Jiwa Enterpreuner Mahasiswa Dan Meningkatkan UMKM Melalui Program Wirausaha Merdeka
Authors: Lenya Ramadhani  , Ute Chairuz M.Nasution
Published: December 2023

It is hoped that the growth and development of entrepreneurship can reduce the number of unemployed and increase prosperity. The entrepreneurial spirit of today's students has begun to decline because most students who have the mindset of wanting to work for a company do not want to create jobs. Entrepreneurship is the ability and willingness to develop, manage and running a business, including taking the risks involved in it to achieve profits, therefore an entrepreneurial spirit is very important for students. There are very few MSMEs (Micro, Small and Medium Enterprises) nowadays due to people's interest in entrepreneurship and their lack of knowledge or insight into entrepreneurship.As for problems with MSMEs in Indonesia, such as weak business management capabilities, limited quality of human resources (HR), and weak access to financial institutions, especially banking. These businesses usually do not have a bookkeeping system, have difficulty expanding the business scale, and still have limited capital. Therefore, this independent entrepreneurship program can foster an entrepreneurial spirit and improve the quality of SMEs. The independent entrepreneurship program activities launched by the Ministry of Education and Culture are intended to study as well as exploring students' abilities to improve their entrepreneurial spirit and urging students to improve their entrepreneurial skills and make a positive impact on society.
Analisis Perlakuan Akuntansi dalam Transaksi Mata Uang Asing terhadap Risiko Keuangan PT. Ramayana Lestari Sentosa Tbk
Authors: Hana Setiyaningsih  , Dila Resti Kamila  , Erinda Ayu Permatasari
Published: December 2023

This research aims to determine foreign currency transactions that occur at PT. Ramayana Lestari Sentosa Tbk in its financial reports is because countries have different currency values. Foreign currency transactions at this company involve the sale and purchase of currency to support business needs and control company risks. The data collection technique used in this research is a qualitative descriptive method. The results of the discussion stated that, PT. Ramayana Lestari Sentosa Tbk noted that foreign currency transactions occur due to import-export, foreign funding and foreign investment. Foreign currency transactions are important in company risk management as a source of good financial strategy.
Implementasi PSAK 10 dalam Menyusun Laporan Keuangan (Transaksi Mata Uang Asing)
Authors: Mia Nurmalia  , Yunita Indah Saputri  , Vanio Bagas Saputra  , Dania Dwi Rinita  , Endang Kartini Panggiarti
Published: December 2023

Accounting for foreign currency transactions is an important aspect in the scope of corporate finance, especially in the context of business globalization. PSAK 10 (Statement of Financial Accounting Standards) regulates this aspect and provides guidelines on how companies should account for transactions in foreign currencies as well as related financial reporting. This research explores the implementation of PSAK 10 in preparing financial reports, with a focus on foreign currency transactions. In PSAK 10, companies are directed to use the foreign currency exchange rate on the transaction date to measure transactions in foreign currency. In addition, significant changes in foreign currency exchange rates after the transaction date are also taken into account and recognized as exchange gain or loss. A deep understanding of the application of these provisions is crucial so that financial reports accurately reflect the company's financial position. Through literature research and analysis of accounting practices, this article investigates how companies effectively manage foreign currency risks and present relevant and reliable information in their financial reports. A comparison between the methods used by companies in implementing PSAK 10 and best practices in the industry is explained to provide a comprehensive picture. It is hoped that the results of this research will provide in-depth insight into the challenges, opportunities and best policies in dealing with foreign currency transactions based on PSAK 10. The practical implications of compliance with this standard, as well as the potential impact on corporate financial decisions, will also be reviewed. With a better understanding of foreign currency transaction accounting, companies are expected to improve the quality and credibility of their financial reports in an ever-expanding global market.
Involvement of Children in Legal Issues for Criminal Acts of Terrorism in Indonesia: Phenomenon and Inflicting Factors
Authors: Priambada Bintara Sura , Suwadi Pujiyono
Published: December 2023

This article discusses the involvement of children in legal issues of criminal acts of terrorism in Indonesia, including a discussion of the phenomena and factors that cause them. This research method is this research using empirical legal research (non-doctrinal). Data collection techniques in this study were carried out through interviews and literature studies. This research also uses deductive reasoning method. The results of the study show the importance of paying attention to the potential for indoctrination of radicalism to children. However, this will be difficult to prevent if the perpetrators of indoctrination are the child's own parents. The risk of indoctrination of radicalism is easier to limit and prevent if the perpetrator is another party who is not a parent. Internal factors that occur and come from within the child. In this case, it is due to the mental condition of the child who is not yet an adult as well as the intervention of the parents who were previously the parents who attracted their children to join the terrorism network. Then external factors that come from outside the child. In this case, it is generally caused by environmental factors, the development of technology and information, as well as things that are not derived from the child's internal factors. Children who are in conflict with the law in criminal acts of terrorism should still receive protection for their rights. One of them is by implementing diversion in every stage that children go through in dealing with the law in criminal acts of terrorism and optimizing deradicalization policies based on the concept of restorative justice.
Purchase of Halal Products for Muslim Households in Indonesia
Authors: Susilawati Nilda , Bon Abdul Talib Bin
Published: December 2023

This research was conducted on Muslim households in Indonesia, because Muslim households because of the understanding and application of halal principles started from families with a sample of 183 people representing one household, namely husband or wife or children. Determination of the sample using random sampling. Data analysis used multiple linear regression analysis and partial test (t). Based on the results of the regression test table, the halal marketing item (X1) shows results with a significant value of 0.0071 which means it is smaller than 0.05 which states that halal marketing has a significant influence on the interest in purchasing halal products in Indonesian households. Meanwhile, the halal awareness item (X2) shows a significant value of 0.1613, halal certification (X3) shows a significant value of 0.4848, and religious belief (X4) shows a significant value of 0.8521. Thus, the results of the regression test for variables X2, X3, and X4 stated that the results of the significant value were greater than 0.05 which stated that halal awareness, halal certification, and religious belief had no significant effect on interest in purchasing halal products in Indonesian households.