bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of the Optimal Position of a Nasal Oxygen Cannula for Apneic Oxygenation - A Technical Simulation
Authors: Wetsch Wolfgang A. , Schröder Daniel C. , Herff Susanne J. , Böttiger Bernd W. , Wenzel Volker , Herff Holger
Published: November 2022

Background. In a cannot ventilate cannot intubate situation, careful preoxygenation with high FiO2 allowing subsequent apneic oxygenation can be life-saving. The best position for an oxygen supply line within the human airway at which oxygen insufflation is more effective than standard preoxygenation with a face mask, or comparably effective as intratracheal insufflation, is unknown. Methods. In this experimental study, we compared effectiveness of preoxygenation by placing an oxygen cannula at the nose entrance, through the nose at the soft palatine, or at the base of tongue; as control we used ambient air. We connected a fully preoxygenated test lung on one side to an oximeter with a flow rate of 200ml/min simulating oxygen consumption of a normal adult, and on the other side to the trachea of an anatomically correctly shaped airway manikin over a 20 min observation period five times for each cannula placement in random order. Results. Oxygen percentage in the test lung dropped from 100% in all groups to 53±1% in the ambient air control group, to 87±2% in the nasal cannula group, to 96±2% in the soft palatine group, while it remained at 99±1% in the base of tongue group (p=0.003 for soft palatine vs base of tongue; and p<0.001 between all other groups). Conclusions. When simulating apneic oxygenation in a preoxygenated manikin, oxygen insufflation at the base of tongue kept oxygen percentage at baseline values of 99% demonstrating a complete block for ambient air flowing into the manikin’s airway. Oxygen insufflation at the soft palatine or insufflation via nasal cannula were less effective in regard of this effect.
Faktor Pengaruh dalam Pembentukan Permukiman Kumuh di Desa Pohuwato Timur
Authors: Gobel Fendy Faizal , T. Zees Eko Adityawan
Published: November 2022

Pohuwato Timur Village is included in several slum areas in Pohuwato District. Most of the residents' houses in this area have low building quality, high building density, narrow road space, poor condition of drainage channels, and accumulation and pollution of river waste. The society also has unhealthy behavior by disposing their solid waste in the river and by using the embankment as the toilet. This research aims at investigating the condition of slums and the factors that influence the creation of slums. The results of the identification and analysis are used as guidelines in making directions for handling regional structuring. Identification of slum conditions is carried out on five indicators. The research method applies a quantitative approach and multiple linear regression analysis. Data collection techniques are questionnaires and observations. The identification results show that in general, it is a medium slum area. The results of the analysis show that residential buildings, environmental roads, drainage channels, wastewater disposal, and solid waste management simultaneously affect the slum conditions of the area, while partially only drainage and waste channels affect the slum conditions of the area. The direction of the arrangement is carried out with a pattern of handling resettlement with the principle of On-site Reblocking arrangement, as well as repair and arrangement of facilities and infrastructure of drainage and waste channels.
Partisipasi Masyarakat dalam Pengembangan Ekowisata di Desa Peliatan, Kecamatan Ubud
Authors: Prasandya Km. Deddy Endra , Satria Made Wina , Nurwarsih Ni Wayan
Published: November 2022

The research that has been conducted has concluded that many villages in Bali are likely to develop into more sustainable ecotourism. One of them is Peliatan Village in Ubud District. Based on the synthesis of ecotourism theories, there are six criteria for ecotourism development, including environmental, community participation, education, economics, socio-cultural, and institutional. The first focus of this research is to find out the importance of community participation as a criterion for ecotourism development. The second is to understand the degree of participation of the Peliatan village community in the development of ecotourism. This research is a mixed-method research, adopting AHP (Analytical Hierarchy Process) methods to form a hierarchical structure of ecotourism development criteria, in order to understand the priority of community participation as an ecotourism standard. The results show that the criterion of community participation ranks third (slightly more important, with a weight of 0.168) after the environmental standard (weight 0.281) and social culture (0.210). Residents of Peliatan Village participate in each of the activities in their village (planning, development, management, monitoring/evaluation), which plays a very important role in the development of Peliatan Village's ecotourism.
Perubahan Tata Ruang dan Fungsi Kampung Akuarium, Jakarta
Authors: Ashadi Ashadi , Nur'aini Ratna Dewi , Lissimia Finta , Anisa Anisa , Wahab Suriani Ngah Abdul
Published: November 2022

Kampung Akuarium is one of the historical places in the coastal area of North Jakarta. At the beginning, the area of Kampung Akuarium was dominated by swamps, so houses were built using stilt house construction. The development into a dense settlement which was then carried out evictions in the area and now it has become a residential area with the establishment of flats whose plans consist of 5 blocks. The purpose of this study is to explore in depth the changes that occur (especially regarding the function and spatial structure of the building and the surrounding environment) in Kampung Susun Akuarium. This study uses a qualitative descriptive method with historical and architectural approaches to analyze problems in depth by exploring social and architectural phenomena. from time to time through detailed and in-depth data collection sourced from observations, interviews, documents and object description reports. Changes that occurred in the Kampung Susun Akuarium Jakarta before and after the eviction were found in land function, type of building, spatial planning, building construction, house function, home ownership status, socio-economic conditions, and behavior.
Kajian Arsitektur Biophilic pada Arsitektur Tradisional Bali sebagai Pendukung Ekowisata di Bali (Studi Kasus: Rumah Adat Bali)
Authors: Artha Pande Putu Dwi Novigga , Warnata Nyoman , Putri Anasta
Published: November 2022

The development of the times indirectly affects human needs which have an impact on all aspects of human life, psychology, lifestyle to architecture.  There are several rules of Traditional Balinese Architecture that contrast or are not suitable when combined with modern architecture that is in demand by today's society. However, if ecotourism buildings in Bali follow the architectural trend in the world, it will violate the Bali Regional Regulation and Bali will lose its architectural identity. There is a gap between traditional Balinese architecture that must be applied with modern architecture which is the current trend. Biophilic Architecture is building's connection to the environment will affect the health of the community both physically and psychologically. In general, the Biophilic approach and Traditional Balinese Architecture are both environmentally based. Therefore, Biophilic Architecture can be a bridge between Traditional and Modern Architecture. Using comparative quantitative research methods with biophilic as an indicator of assessing traditional Balinese architecture, the results of modern architecture guidelines that have environmental-based traditional rules will be obtained. This research is expected to be a guide or reference in designing ecotourism buildings that are modern but still strong in their traditional Balinese identity.
Kajian Kelayakan Kawasan Arkeologi Lembah Bengawan Solo Purba di Pracimantoro sebagai Wisata Edukasi di Jawa Tengah
Authors: Putri Dewi Widowati , Purwani Ofita , Triratma Bambang
Published: November 2022

Pracimantoro has various tourism potentials, one of which is the Gunung Sewu area which is recognized by UNESCO as a global geopark. In one part of the geopark, there lies Bengawan Solo Purba valley which is the ancient Bengawan Solo river flow. Considering the significance of Bengawan Solo to the life of the Javanese people, and its archaeological values, this valley has the potential to be developed into a tourism object. This paper focuses on the feasibility study of the development of this valley into a tourist destination. The method used in this study is SWOT analysis to discuss the strengths, weaknesses, opportunities, and threats of Bengawan Solo Purba Valley. The results of the study show that it is possible to develop this area as a tourist destination but for educational tourism purposes focusing on archaeology.
Mitigasi Bencana Banjir pada Bangunan Sekolah Melalui Tata Lanskap
Authors: Sunoko Kahar , Sumadyo Amin , Kumoro W Agung , Farkhan Akhmad
Published: November 2022

Vulnerability to flood hazards occurs at SD Iroyunan, Pajangan, Bantul, which is located in the Bedog river watershed and the landscape pattern of the area is quite steep. The morphology of the area indicates that its development lacks insight into the potential for flooding and on sustainable landscape management. This phenomenon shows that there is a gap, so it is necessary to study the landscape. The study was carried out in a descriptive exploratory manner, to obtain a detailed description of the landscape pattern and vulnerability of the school site area. This study resulted in findings about patterns of landscape vulnerability and school landscape models in flood disaster preparedness.
Studi Pengaruh Kualitas Jalur Pedestrian terhadap Tingkat Sense of Place Sebuah Kasus di Pusat Kota Banda Aceh
Authors: Martin Martin , Wulandari Elysa , Muliadi Muliadi
Published: November 2022

Banda Aceh as the capital city of Aceh province has been the capital since the royal era and continues to grow, especially kawasan simpang lima which is strategic because it connect 5 primary roads in Banda Aceh city, one of them is st. Teuku Panglima Polem, it is a primary road that connected to some multi-culture village as a commercial area and chinatown. Teuku Panglima Polem road should be grow with a variety of cultures that seen in the city elements. However, based on observation, the feel of cultural diversity as a sense of place of Teuku Panglima Polem street’s pedestrian ways is less pronounced. This study aims to identify the level of sense of place, to test and analyze the influence of pedestrian ways towards sense of place, and to give solution on problem of sense of place. This study is a causal associative study with quantitative method. The data collection methods are distribution of questionnaries, observation, unstructured interview, and literature studies. The sampling method is non-probability sampling using purposive sampling technique. Data analysis technique are using statistics descriptive analysis and multiple linear regression analysis. The result of this study is the level of sense of place on st. Teuku Panglima Polem is “belonging to a place”, the pedestrian ways has a significant positive influence towards the sense of place, and the visualization of design recommendation.
Effect of Alkaline Treatment and Fumigation (Fumigation) on the Mechanical Properties of Fiber Unsaturated Polyester-Cantula Composite with Compression Molding Method
Authors: Ramadhan M. Rafidya Bintang , Salim Muhamad Saifuddin , Fanani Elvira , Ariawan Dody , Surojo Eko
Published: November 2022

This research examines the strength of the UPRs-Cantula composite with the
addition of filler microcrystalline cellulose (MCC). Composites were created
with a volume fraction of 30% Vf and a 45° angle. This angle variation received
the same treatment as the others, including untreated, alkaline, and fumigation.
The treatment time for alkali treatment was 6 hours, while the treatment time
for fumigation was 10 hours. The strength of each angle variation was
determined, as well as its treatment of tensile strength, modulus of elasticity,
and Poisson's ratio UPRs-cantula composites. According to the results, the
alkali treatment produced the highest tensile strength and elastic modulus
values. The highest Poisson ratio value was discovered without treatment at a
45°. The alkaline treatment yielded the highest tensile strength and modulus of
elasticity test results. The pullout fiber fracture dominated the untreated
composite fracture, whereas the fiber breakage fracture dominated the alkaline
treatment.
Effect of Holding Time and Temperature of Hot Pressing on Tensile Strength of Biodegradable Plastic Made of Carrageenan
Authors: Imaduddin Fitrian , Sastra Palgunadi , Raharjo Wijang Wisnu , Wullandari Putri , Ridwan Ridwan
Published: November 2022

The most significant environmental problem was caused by plastic. One way to handle plastic waste was using biodegradable plastic because it faster decomposes naturally. Biodegradable plastic can be made from carrageenan by the hot press method. This method can make biodegradable plastic with large dimensions. However, the plastic quality depended on the holding time, temperature, and pressure selected during the hot pressing process. Therefore, this research is conducted to determine the effect of holding time and temperature in the hot press process on the tensile strength of biodegradable plastic made from carrageenan. The composition of the biodegradable plastic material used was 35% carrageenan, 35% polyvinyl alcohol (PVA), and 30% glycerol. In the manufacture of composites, the holding time was varied: 10, 20, 30, and 40 minutes, as well as the process temperature varied from 100, 110, 120, and 130 °C. The tensile strength of the composite was observed through tensile testing using a Universal Testing Machine. FTIR, XRD, and SEM tests were also conducted to sharpen the analysis. The addition of holding time led to an increase in the tensile strength of biodegradable plastics. The highest tensile strength was obtained at a holding time of 30 minutes with a value of 4.45 MPa. After 30 minutes, the tensile strength of the biodegradable composite decreased. Meanwhile, the addition of process temperature caused a decrease in the tensile strength of biodegradable plastics. The highest tensile strength was obtained at a process temperature of 100 °C with a value of 5.28 MPa.
Prospects and State of the Glass Industry in Saudi Arabia and a preliminary assessment of the quality of Glass and Glass-Ceramics Fabrication
Authors: Mahmoud Essam R. I. , Shaharoun Awaluddin Mohamed , Aljabri Abdulrahman , Almohamadi Hamad , Farhan Mohammed
Published: November 2022

Although the economic value of glass products and its importance to the Saudi National Economy is vast, not much information is available about the current state of the art of the industry. Likewise little information is available about the geography, potential sites for mining sand as well as the evaluation of sand quality. This paper attempts to bridge this gap by presenting a feasibility study of fabricating normal glass and glass ceramics from Saudi Arabia’s domestically available raw materials. It discusses the current status of glass industry in Saudi Arabia and the Middle East region. It also gives a brief explanation about the sand topography in Saudi Arabia. In order to determine the feasibility of fabricating glass using these raw materials, experimental data on the fabrication of normal glass and glass-ceramics from indigenously available raw materials was obtained and reported as part of the findings of this paper Firstly, normal transparent glass were able to be fabricated without any apparent large defects using sand collected from Ar-Rayis region in Saudi Arabia. Four nano-sized crystallization catalysts, namely VC, WC, TiC and Y2O3, were added to the constituents of the glass in 3 wt.%.  For VC, the crystallization process was limited. The glass ceramics of WC consisted of multi-dimensional edges crystals which covered all the matrix. Gray crystalline whiskers were obtained by addition of TiC. The Y2O3- glass ceramics consisted of multi-directionally rosette crystals. Finally, the microhardness values of the added crystallization catalysts glass ceramics were obtained and found to be much higher compared to normal glass. The results show that glass of high quality can be produced specifically for Ar—Rayis region which would be of interest to researchers, glass industry personnel and potential investors
Pseudoconcreción y movimiento estudiantil
Authors: Salas Plata Mendoza Jorge Arturo
Published: November 2022

La presente reseña aborda el filme de Canoa del director Felipe Cazals desde un enfoque filosófico bajo la óptica de Karel Kosik y el movimiento estudiantil de 1968 en México.
THE SIMULATION AND DATA ANALYSIS OF TEMPERATURE SENSOR
Authors: Ramadhan Hilal Fauzi , Sari Retno Dwi Kartika , Alamsyah Adnan Prasetyo , Fadhillah Adrian , Nurhikmah Rizki , Miftahulfallah Sarah Aribah , Rahma Widya , Firia Ari , Saputri Dea Amelia , Irmansyah Irmansyah , Irzaman Irzaman
Published: November 2022

The study have successfully simulated 40 units data of temperature sensor during heating process and cooling process. Simulated data in temperature sensor has interval time 3 to 18 seconds for 5 iterations that are combined with other 7 data temperature sensor until get 40 data iterations. The data which has been simulated and then plotted into a graph with the x-axis is time and y-axis is average  heating process or cooling process. The graph formmed cupped-down with quadratic function for heating process and cupped-up for cooling process.
THE RELATIONSHIP BETWEEN TIME AND WATER CONTENT OF FISH DRIED USING SOLAR PANEL-BASED DRYERS
Authors: Sutrisno Sutrisno , Puspitasari Rindang Wahyu , Pamungkas Anang , Suaidi Daeng Achmad
Published: November 2022

Traditional drying of fish, the water content produced is not in accordance with SNI (Indonesian National Standard), which is less than 40%. This research aims to determine the correlation between time and water content of fish dried with an electric-based fish dryer produced from solar panels. The method used is a quantitative method. The solar panel-based electric fish dryer has a maximum capacity of 2237 grams (12 fish) with a temperature above 30°C. Based on the data analysis, the correlation between time and water content was obtained, the results for the 1st, 2nd and 3rd experiments, the average correlation coefficient was R² = 0.99, and the correlation between the mass of dried fish and the water content of fish, the more mass of fish that is dried the more water content evaporates (dry), To meet the water content of fish that is permitted according to SNI, which is less than 40%, it takes a long time to dry. about 4 days. The heating system in the drying chamber was based on the first experiment until the third experiment, the heat was evenly distributed and quite good in the drying chamber, so that the temperature control system worked well. This solar panel-based fish drying system can be used by fishermen to lighten fish in improving the quality of their products according to SNI.
LINEAR GENERATOR PROTOTYPE WITH VERTICAL CONFIGURATION OF SEA WAVE POWER PLANT
Authors: Prasetyowati Ane , Broto Wisnu , Suryaningsih Noor
Published: November 2022

There are three types of potential energy sources in the sea: ocean wave energy, tidal energy, and ocean heat energy. Ocean wave energy is a source of considerable energy. Sea waves are an up and down movement of seawater where the energy of sea waves is generated through the effect of air pressure movement due to fluctuations in ocean wave movements. The Ocean Wave Power Plant can use ocean wave energy to convert it into electrical energy. A linear generator is a device that can convert the mechanical energy of linear motion into electrical energy. The application of the ocean wave energy conversion technology, a linear generator system is an electrical machine that functions to convert the mechanical energy of linear motion into electrical energy using the principle of electromagnetic induction. Wave Energy Converter (WEC) technology has been developed with various methods. From the various existing concepts and designs, in general, WEC technology can be classified into three main types, namely Attenuator (horizontal configuration), Point Absorber (linear configuration), Terminator (damping configuration).
IMPACT PROFILE OF ENSO AND DIPOLE MODE ON RAINFALL AS ANTICIPATION OF HYDROMETEOROLOGICAL DISASTERS IN THE PROVINCE OF SOUTH SUMATRA
Authors: Ariska Melly , Akhsan Hamdi , Muslim Muhammad
Published: November 2022

El Niño Southern Oscillation (ENSO) is a weather phenomenon in the Pacific Ocean. At the same time, Dipole Mode (DM) is an ocean-atmosphere interaction phenomenon in the Indian Ocean. The area of South Sumatra Province, which is in the Monsunal area, makes the influence of ENSO and DM very instrumental in determining the length of the rainy season and throughout the year. The South Sumatra region is very vulnerable to forest and land fire disasters due to the condition of the area in the form of swamps and peatlands, which are very easy to burn if the dry season occurs in the South Sumatra area. In this study, an analysis of the effect of ENSO and DM on rainfall in the South Sumatra Region from 1981 to 2020 was carried out using a simple linear regression method and the correlation coefficient using Niño 3.4 index data and Dipole Mode with rainfall data and consecutive rainy days data. Consecutive Wet Day (CWD). The purpose of this study was to determine the effect of Enso and Dipole Mode on rainfall and CWD in the South Sumatra Region. The results show that the correlation between ENSO and rainfall is 0.0017-0.002573, DM and rainfall is 0.05972, and ENSO and CWD is -0.068. The correlation between DMI and CWD is 0.513. So it can be said that ENSO and DMI have no effect on rainfall in the South Sumatra Province. Still, the amount of CWD in South Sumatra Province is significantly determined by the Dipole Mode Index (DMI) at a moderate level. The number of consecutive rainy days in South Sumatra Province is influenced by the dynamics of the ocean and atmosphere of the Indian Ocean, which is characterized by the presence of positive IOD and negative IOD phenomena.
TINJAUAN PUSTAKA SISTEMATIS: PENERAPAN DATA MINING TEKNIK CLUSTERING ALGORITMA K-MEANS
Authors: Sekar Setyaningtyas  , Indarmawan Nugroho Bangkit , Arif Zaenul
Published: November 2022

Data Mining adalah metode untuk menganalisis pola dan karakteristik di masa depan serta untuk mengumpulkan informasi tak terduga yang belum pernah terlihat sebelumnya dari database yang besar. Dalam data mining, clustering adalah salah satu teknik yang berguna untuk analisis data. Salah satu algoritma data mining adalah algoritma K-Means yang merupakan teknik clustering berdasarkan pembagian jarak. Tujuan yang ingin dicapai dalam paper ini yakni menganalisis teknik clustering menggunakan algoritma K-Means dalam data mining dengan melakukan review secara mendalam dan mengevaluasi penelusuran melalui literatur terpilih berdasarkan kriteria tertentu dan studi yang dipilih akan diproses untuk menjawab pertanyaan penelitian. Tinjauan Pustaka Sistematis (Systematic Literature Review/SLR) merupakan sebuah metode penelitian yang bertujuan untuk mengidentifikasi dan mengevaluasi hasil penelitian dengan teknik terbaik berdasarkan prosedur yang spesifik dari hasil perbandingan. Berdasarkan pemilihan literatur publikasi jurnal, Pattern Recognition, Knowledge-Based System, Applied Soft Computing dan IEEE Access dapat menjadi rujukan utama terkait algoritma K-Means. Metode atau teori perhitungan jarak yang sering digunakan terkait algoritma K-Means yakni Euclidean Distance, Elbow Criterion, dan Lloyd Algorithm. Hasil perbandingan metode menunjukkan bahwa Euclidean Distance memiliki keunggulan perhitungan jarak yang lebih baik.

 

Kata Kunci—data mining, clustering, K-Means, tinjauan pustaka sistematis.
RICE OF INTENSIFICATION SYSTEM BASED ON MICROCONTROLLER-BASED RICE OF INTENSIFICATION
Authors: Candra Adi , Farida Farida , Sulaiman Husni
Published: November 2022

Pengairan irigasi pertanian merupakan upaya yang dilakukan petani untuk menjaga konsistensi ketersediaan air pada lahan pertanian. Namun pemakaian air terutama pada musim kemarau tidak dapat diatur dengan baik sehingga pemakaian air untuk mengatur pengairan sawah tidak sesuai dengan kebutuhan. Pengaturan air dibuat dengan tujuan dapat mencukupi kebutuhan air secara merata disetiap lahan, infomasi dari beberapa kelompok tani Mattirobulu di Desa Dampang, Kecamatan Gantarang, Kabupaten Bulukumba, diperoleh informasi bahwa, sampai saat ini pembagian air irigasi melalui pintu-pintu irigasi dilakukan secara manual, sehingga pembagian air pada lahan sawah tidak berjalan sesuai dengan harapan karena adanya beberapa kelompok tani serta adanya beberapa orang atau oknum yang tidak bertanggung jawab melakukan kecurangan dalam hal pembagian air. Sehingga timbul masalah seperti, hilangnya saling percaya antar petani, sampai pada terjadinya pertikaian antara petani tujuan dari penelitian ini adalah Merancang  prototype sistem kontrol pengairan sawah secara System Rice of Intensification (SRI) berbasis Manfaat Penelitian adapun manfaat yang diharapkan dari penelitian ini adalah Prototype sistem kontrol pengairan sawah menggunakan metode System Rice of Intensification (SRI) berbasis mikrokontroler yang dihasilkan dapat digunakan sebagai media pembelajaran dalam mengembangkan pertanian dan mampu mengatur pengairan sawah secara SRI
Mental Health of Brazilian Immigrant Women: The Role of Discrimination, Social Support, and Community Strengths
Authors: Allen Jennifer D. , Kunicki Zachary J. , Greaney Mary L.
Published: November 2022

Background: Little is known about the mental health status of Brazilians living in the U.S. We assessed the prevalence and correlates of depression among Brazilian women living in the U.S. to guide the development of culturally relevant community-based mental health interventions.
Method: We conducted an online survey among a convenience sample of Brazilian women living in the U.S. between July and August 2020. Eligible participants (age 18 and over, born in Brazil, English or Portuguese speaking) were recruited through Brazilian social media pages and community organizations. The survey included items to assess depression using the Center for Epidemiological Study Depression Scale (CES-D-10), as well as the Everyday Discrimination Scale (EDS), Oslo Social Support Scale (OSSS), as well as perceived community strengths (CS). We first assessed the correlation between CES-D-10 scores and EDS, OSSS, and CS. We then constructed multiple linear regression models to examine the relationships between EDS, OSSS, and CS with CES-D-10 scores.
Results: Participants (N=353) had a mean age of 39 years (SD = 12). Most spoke Portuguese (99.7%), and the majority also reported being proficient in English (70.2%). CES-D-10 scores ranged from 2 to 29, with a mean of 11.4 (SD = 6.2). Nearly half of the participants (47.4%) had CES-D-10 scores of 10 or greater, indicating the presence of depressive symptomatology. In a multivariable model controlling for significant covariates (age, time lived in U.S.), EDS was positively associated with CES-D-10 scores (β = 0.64, 95% CI = 0.45, 0.83), while OSSS was negatively associated with CES-D-10 scores (β = -0.53, 95% C I= -0.80, -0.27). No statistically significant relationship was observed between CES-D-10 and CS scores.
Conclusions: In this sample of Brazilian immigrant women, depressive symptomatology was highly prevalent, and experiences of discrimination were associated with increased symptoms of depression. There is a need to understand and address mental health in Brazilian immigrant women.
Traces of Electron-Phonon Coupling in One-Dimensional Cuprates
Authors: Tang Ta , Moritz Brian , Peng Cheng , Shen Zhi-Xun , Devereaux Thomas
Published: November 2022

The appearance of certain spectral features in one-dimensional (1D) cuprate materials has been attributed to a strong, extended attractive coupling between electrons. Here, using time-dependent density matrix renormalization group methods on a Hubbard-extended Holstein model, we show that extended electron-phonon (e-ph) coupling presents an obvious choice to produce such an attractive interaction that reproduces the observed spectral features and doping dependence seen in angle-resolved photoemission experiments: diminished $3k_F$ spectral weight, prominent spectral intensity of a holon-folding branch, and the correct holon band width. While extended e-ph coupling does not qualitatively alter the ground state of the 1D system compared to the Hubbard model, it quantitatively enhances the long-range superconducting correlations and suppresses spin correlations. Such an extended e-ph interaction may be an important missing ingredient in describing the physics of the structurally similar two-dimensional high-temperature superconducting layered cuprates, which may tip the balance between intertwined orders in favor of uniform $d$-wave superconductivity.
Current floods in Pakistan are expected to have continuing adverse effects on food security beyond the current year: a remote sensing perspective
Authors: Khan Mobushir Riaz , Barrett-Lennard Edward , Punthakey Jahangir , Finlayson C.Max , Nangraj Mustafa
Published: November 2022

Since June 2022, many countries from Africa to Asia and Australia to Europe are affected by flash floods. Climate change induced floods in Pakistan have affected about 33 million people requiring assistance amounting to USD $160.3. The situation is further exacerbated by the imminent food insecurity crisis. We show through the analysis of satellite images that in total 78% (3.9 Mha) of the culturable land is affected. Major crops in the current wet season of Sindh province have been inundated including rice (98% flooded), followed by the cotton and sugarcane areas (81% and 71% flooded respectively). Further, about 86% of wheat growing areas will not be available for cultivation in this winter season. Information extracted from the satellite imagery can be used by policymakers to direct resources to assist in the recovery and rehabilitation of agricultural systems destroyed by the floods.
Association between Ambulatory Arterial Stiffness Index and Blood Pressure Variability: A Cross-Section Study
Authors: Cao Rong , Gao Ting , Yue Jianwei , Sun Gang , Yang Xiaomin
Published: November 2022

Ambulatory arterial stiffness index (AASI), a surrogate marker of arterial stiffness derived from ambulatory blood pressure (BP), which is calculated as 1 minus the linear slope of diastolic BP on systolic BP. Our study aim was to investigate the association between AASI and BP variation parameters, evaluated by both circadian rhythms and 24h coefficient of variation (CoV) in a population of normotension, untreated hypertension, controlled hypertension, uncontrolled hypertension, white coat hypertension and white coat uncontrolled hypertension. 610 subjects (48.7% female, age 60.9 ± 13.2 years), who underwent 24h ambulatory blood pressure monitoring were included; AASI was significantly higher in reverse-dipping than other dipping patterns, both in systolic and diastolic BP (p< .05). In a multiple linear regression analysis, circadian rhythms and 24h CoV in diastolic BP were independently associated with AASI after adjusted for multiple confounders (β=-0.002, 95% Cl -0.004~-0.001, P= .0004; β=-0.56, 95% Cl -0.78~-0.33, P< .001); the association between circadian rhythms and AASI were consistent across subgroups defined according to age, sex, BP phenotypes, smoking status, and white coat effect (p for interaction all>0.05). In conclusion, in subjects of different BP phenotypes, AASI was significantly associated with circadian rhythms and 24h CoV.
A novel non-invasive biomarker based on oral microbiome dysbiosis for detection of Community-Acquired Pneumonia
Authors: Sun Ni , Zhang Xuhan , Hou Yating , Zhong Ting
Published: November 2022

Background: Early diagnosis of pathogenic bacteria is crucial for the treatment of community-acquired pneumonia (CAP), but conventional diagnostics are limited by sampling difficulties. Oral microbiota has also been explored as a noninvasive biomarker of lung diseases, but it’s role in CAP has been neglected. We aimed to investigate whether the oral bacteria can be novel non-invasive biomarkers for CAP.
Methods: Oral swab samples were collected from 29 patients with CAP and 26 healthy volunteers and characterized based on clinical parameters and 16S rRNA profiling of oral bacteria. A predict functional profiling was performed for the functional and metabolic changes in oral microbial communities.
Results: Oral microbial of patients with CAP had a lower diversity than healthy group. And the dominant bacteria were Streptococcus, Prevotella and­ Neisseria in CAP. Higher abundance of­ Prevotella (particularly Prevotella_melaninogenica), ­Veillonella and ­ Campylobacter, and lower abundance of Neisseriaand ­ Fusobacterium were detected in CAP group. Analysis of the functional potential of oral microbiota demonstrated that the pathway involving infectious disease was overrepresented in the CAP groups relative to that in the healthy controls.
Conclusions: Oral microbial dysbiosis was found in patients with CAP, supporting the use of this non-invasive specimen for biomarkers of CAP.
Effects of worries about hospital treatments or follow-up appointments during COVID-19 pandemic on supportive care needs in cancer patients
Authors: Chang Wen-Pei , Lin Chia-Chin
Published: November 2022

Purpose
With the basic characteristics of cancer patients as an independent variable and anxieties over hospital admission for medical treatment or follow-up appointments after the outbreak of COVID-19 as a moderator, this study explored how the two variables affected the supportive care needs of cancer patients.
Methods
In this cross-sectional study, 135 hospitalized patients in oncology wards were recruited from a teaching hospital in Taiwan from August 2021 to December 2021. Research tools used to complete our survey included general patient information sheets, patient characteristics, a survey on the impact of COVID-19, and the Supportive Care Needs Survey-short form.
Results
That 83 participants (61.5%) were worried about visiting hospitals for cancer treatment or follow-up appointments during the COVID-19 pandemic. Multiple regression results revealed that an interaction occurred depending on marital status when the health system and information needs of patients had an effect on their worries about visiting hospitals for cancer treatment or follow-up appointments (B = 4.45, p = .015). An interaction also occurred depending on marital status when the sexual needs of patients had an effect on their worries about hospital treatment or follow-up appointments (B = 11.95, p = .006). An interaction occurred depending on the stage of cancer when the physical and daily living needs of patients exerted an effect on their worries about going to hospital for cancer treatment or follow-up appointments (B = 7.80, p = .002).
Conclusion
The relationship between the basic characteristics and supportive care needs of patients can change owing to their worries about hospital treatments or follow-up appointments during the COVID-19 pandemic.
The effects of regional quadriceps architecture on angle-specific rapid torque expression
Authors: Oranchuk Dustin J. , Hopkins William G. , Cronin John B. , Storey Adam G. , Nelson André R.
Published: November 2022

Evaluating anatomical contribution to performance can build an understanding of muscle mechanics and guide physical preparation. While the impact of anatomy on muscular performance is well studied, the effects of regional quadriceps architecture on rapid torque expression are less clear. Regional (proximal, middle, distal) quadriceps (vastus lateralis, rectus femoris, lateral and anterior vastus intermedius) thickness (MT), pennation angle (PA), and fascicle length (FL) of 24 males (48 limbs) were assessed via ultrasonography. Participants performed isometric contractions at 40º, 70º, and 100º of knee flexion to evaluate rate of torque development from 0-200 ms (RTD0 − 200). Measurements were repeated on three separate occasions with the greatest RTD0 − 200 and average muscle architecture measures used for analysis. Linear regression models predicting angle-specific RTD0 − 200 from regional anatomy provided adjusted simple and multiple correlations (√adjR2) with bootstrapped compatibility limits to assess magnitude. Mid-rectus femoris MT (√adjR2 = 0.41–0.51) and mid-vastus lateralis FL (√adjR2 = 0.41–0.45) were the best single predictors of RTD0 − 200, and the only measures to reach acceptable precision with 99%CL. Small simple correlations were found across all regions and joint angles between RTD0 − 200 and vastus lateralis MT (√adjR2 = 0.28 ± 0.13; mean ± SD), vastus lateralis FL (√adjR2 = 0.33 ± 0.10), rectus femoris MT (√adjR2 = 0.38 ± 0.10), and lateral vastus intermedius MT (√adjR2 = 0.24 ± 0.10). Multiple correlations are reported within the article. Researchers should measure mid-region rectus femoris MT and vastus lateralis FL to efficiently and robustly evaluate potential anatomical contributions to changes in rapid knee extension torque expression.
Unbound IRF2 to IRF2BP2 mediates KLF4 signaling leading to anti-inflammatory phenotype of microglia
Authors: Kim Jiwon , Sim A Young , Barua Sumit , Kim Jong Youl , Lee Jong Eun
Published: November 2022

Background
Following central nervous system (CNS) injury, the investigation for neuroinflammation is vital because of its pleiotropic role in both acute injury and long-term recovery. Agmatine (Agm) is well known for its neuroprotective effects and anti-neuroinflammatory properties. However, Agm’s mechanism for neuroprotection is still unclear. We screened target proteins that bind to Agm using a protein microarray; the results showed that Agm strongly binds to interferon regulatory factor 2 binding protein (IRF2BP2), which partakes in the inflammatory response.
Methods
To confirm the relationship between Agm and IRF2BP2 in neuroinflammation, we used microglia cell-line (BV2) and treated with lipopolysaccharide (LPS; 20 ng/ml) and interleukin (IL)-4 (20 ng/ml). Although Agm bound to IRF2BP2, it failed to enhance IRF2BP2 expression in BV2.
Therefore, we shifted our focus onto interferon regulatory factor 2 (IRF2), which is a transcription factor and interacts with IRF2BP2.
Results
IRF2 was highly expressed in BV2 after LPS treatment but not after IL-4 treatment. When Agm bound to IRF2BP2 following Agm treatment, the free IRF2 translocated to the nucleus of BV2. The translocated IRF2 activated the transcription of Kruppel-like factor 4 (KLF4), causing KLF4 to be induced in BV2. The expression of KLF4 increased the CD206-positive cells in BV2.
Conclusion
Taken together, unbound IRF2, resulting from the competitive binding of Agm to IRF2BP2, may provide protection against neuroinflammation via an anti-inflammatory mechanism of microglia involving the expression of KLF4.
Fixed points of completely positive maps and its dual maps *
Authors: Zhang Haiyan , Dou Yanni
Published: November 2022

Let A ⊂ B(H) be a row contraction and Φ_A determined by A be a completely positive map on B(H). In this paper, we mainly consider fixed points of Φ_A and its dual map {Φ_A}^ † . It is given that Φ_A(X) ≤ X (or Φ_A(X) ≥ X) implies Φ_A(X) = X and {Φ_A}^ † (X) = X when X ∈ B(H) is a compact operator. Some necessary conditions of Φ_A(X) = X and {Φ_A}^ † (X) = X are given.
MR (2010) Subject Classification 47A05; 47A62
MicroRNA-628-3p inhibits glioblastoma cell proliferation and GSC maintenance by directly targeting BTK
Authors: Xu Guanhua , Wang Yuhang , Cao Wenping , Lv Kun , Zhou Fengqi , Liu Ning , Zhang Rui , Wang Binbin
Published: November 2022

Differentially expressed microRNAs (miRNAs) have been identified as a critical factor of glioblastoma (GBM). Therefore, we analyzed the pathogenic mechanism of a new miRNA (miR-628-3p) in glioblastoma. We identified miR-628-3p expression using qRT-PCR and FISH test, and a lot of in vitro tests looked at how miR-628-3p and BTK work biologically. Using a dual luciferase reporter experiment, the target site and mechanism of miR-628-3p binding to BTK were identified. Subcutaneous carcinogenesis was utilized to demonstrate the functionality of miR-628-3p in vivo. Inhibiting GBM growth and GSC maintenance was miR-628-3p overexpression. In addition, miR-628-3p regulated the expression of BTK, which was found as a promoter of GBM development in the research. Our findings showed that miR-628-3p reduces GBM growth and GSC maintenance, suggesting a potential therapeutic target for glioma treatment.
Breast Conserving Surgery Guided with Magnetic Seeds vs Wires: la Paz University Hospital Experience
Authors: Moreno-Palacios Elisa , Martí Covadonga , Frías Laura , Melendez Marcos , Loayza Adolfo , Roca María Jose , Cordoba Vicenta , Oliver Jose Maria , Hernandez Alicia , Sanchez-Mendez Jose Ignacio
Published: November 2022

Background: In recent years, there has been an increase in breast surgery for nonpalpable lesions. Traditionally, wires have been used to guide the resection of nonpalpable breast tumors. Recently, several devices have been commercialized as alternatives to classical wires, such as magnetic seeds (Magseed®). The aim of this study is to describe our initial experience using magnetic seeds (Magseed®) to guide breast-conserving surgery in nonpalpable breast lesions and compare the use of magnetic seed with wires to guide breast-conserving surgery, in terms of clinical and pathological characteristics.
Methods: We performed a retrospective study including all breast-conserving surgeries for nonpalpable breast lesions <16 mm, from June 2018 to May 2021. We compared breast-conserving surgeries guided with magnetic seeds to those guided with wires, analyzing: tumor, and patient characteristics, surgical time, and pathological results of the surgical specimens.
Results: Data from 225 cases was collected, 149 magnetic seeds and 76 wires. The breast lesion was localized in every case. Both cohorts were similar regarding clinical and pathological characteristics. We found significant statistical differences (p <0.02) in terms of the median volume (cm3) of the excised specimen, which was lower (29.3%) in the magnetic seed group compared with the wire group (32.5 [20.5-60.0] / 46.0 [20.3-118.7]). We did not find significant differences regarding surgical time (min), and affected or close margins.
Conclusion: In our experience, the use of magnetic seed (Magseed®) is a feasible option to guide breast-conserving surgery of non-palpable lesions and enable us to resect less breast tissue.
Dual-specificity phosphatase 5 is a novel target gene of miR-216a-3p, inhibits the proliferation and invasion of fibroblast-like synoviocytes
Authors: NI Rongrong , Liu Heting , Song Guojing , Fu Xiaohong , Deng Bingqian , Xu Zhizhen , Dai Shuang-shuang , Huang Gang
Published: November 2022

Dual-specificity phosphatase 5 (DUSP5) is a novel anti-inflammatory modulator in many inflammatory diseases. However, the role of DUSP5 in the fibroblast-like synoviocytes (FLS) of Rheumatoid arthritis (RA) remains unknown. In this study, we aimed to explore the biological function and regulation of DUSP5 in FLS. We found that lower DUSP5 expression levels were detected in collagen-induced arthritis (CIA) and synoviocytes MH7A. Overexpression of DUSP5 markedly decreased the proliferation, migration, and invasion of MH7A, which correlated with suppressing the phosphorylation of ERK. Moreover, DUSP5 was identified as a novel target gene of miR-216a-3p, which is upregulated in FLS. Therefore, DUSP5 expression was negatively regulated by miR-216a-3p, and the effect of DUSP5 overexpression on FLS was reversed by miR-216a-3p mimics. Overall, our study demonstrates that DUSP5 is a miR-216a-3p target gene and its anti-inflammatory function in FLS via inactivation of ERK. These results revealed that the miR-216a-3p/DUSP5 pathway may play a crucial role in the malignant behavior of FLS, which may serve as a new target for the treatment of RA.
How Friction and Pore-Fluid Pressure Conditions Controlled by Fault Mineral Composition Affect Earthquake Rupture Propagation
Authors: Tsuda Kenichi , Hirono Tetsuro
Published: November 2022

Although direct recovery of frictional features of fault rocks through drilling projects and multiple experimental analyses, such as the Japan Trench Fast Drilling Project and the Nankai Trough Seismogenic Zone Experiment have been recently performed, the conditions of rupture propagation to levels of friction and pore-fluid pressure remains uncertain. In order to invest such issues, we performed dynamic rupture simulations based on experimental friction datasets measured in fault rocks on the Nankai Trough that was ruptured during the 1944 Mw8.0 Tonankai earthquake. A steady-state friction triggered large slip (about 30 m) near the trench, whereas a high friction suppressed the rupture. The condition in which the pore-fluid pressure was nearly equal to the lithostatic stress decreased the slip about 25 m in case of low friction. However, in case of high friction with negative stress drop, the slip reached to around 20 m, because the low shear strength did not arrest the inertial motion of rupture propagation. Such differences in fault-rock properties and fluid conditions, controlled by fault mineral composition, may fundamentally influence on the complexity and the variability of rupture propagation.
A novel candidate gene CLN8 regulates fat deposition in avian
Authors: Li Xiaoqin , Zhang Fan , Sun Yunxiao , Sun Dandan , Yang Fangxi , Liu Yongtong , Hou Zhuo-cheng
Published: November 2022

Background
The fat deposition has a crucial role in animal meat flavor, and fat deposition-related traits are vital for breeding in the commercial duck industry. Avian fat-related traits are typical complex phenotypes, which need a large amount of data to analyze the genetic loci.
Results
In this study, we newly phenotyped fat traits and genotyped whole-genome variations for 1246 ducks, and combed with previous GWAS data to reach 1880 ducks for following analysis. The carcass composition traits, subcutaneous fat weight (SFW), subcutaneous fat percentage (SFP), Abdominal fat weight (AFW), Abdominal fat percentage (AFP) and the body weight of day 42 (BW42) for each duck were collected. We identified a set of new loci that affect the traits related to fat deposition in avian. Among these loci, Ceroid-lipofuscinosis, neuronal 8 (CLN8) is a novel candidate gene controlling fat deposition. We investigated its novel function and regulation in avian adipogenesis.Five significant SNPs and a single haplotype were detected in the upstream of gene CLN8 and the most significant SNP (P-value = 21.37E-12) for subcutaneous fat percentage was obtained. Subsequently, luciferase assay demonstrated that five linkage mutations in the upstream of the CLN8 gene significantly decreased the transcriptional activity of CLN8. Further, ATAC-seq analysis showed that transcription factor binding sites were identified in a region close to the haplotype. A set of luciferase reporter gene vectors that contained different deletion fragments of the CLN8 promoter were constructed, and the core promoter area of CLN8 was finally identified in the − 1884/-1207 bp region of the 5′ flanking sequences, which contains adipogenesis-related transcription factors binding sites. Moreover, the over-expression of CLN8 can remarkably facilitate adipocyte differentiation in ICPs. Consistent with these, the global transcriptome profiling and functional analysis of the over-expressed CLN8 in the cell line further revealed that the lipid biosynthetic process during the adipogenesis was significantly enriched.
Conclusions
Our results demonstrated that CLN8 is a positive regulator of avian adipocyte differentiation. These findings identify a novel function of CLN8 in adipocyte differentiation, which provides important clues for the further study of the mechanism of avian fat deposition.