bluuebunny/crossref_metadata_2025 huggingface dataset:
Proclaiming the reign of God in a suffering world: The movement from development to liberation
Authors: Lamberty Kim
Published: February 2017

Today’s missionary, whether long-term or short-term, church-based or part of a faith-based NGO, is faced with grinding poverty and the extreme isolation and marginalization of vulnerable populations. This article will develop a theological foundation that calls missionaries to address the root causes of poverty as a key element of proclaiming the Good News, and will conclude with specific and concrete recommendations for doing so. The article places liberation theology in dialogue with Catholic Social Teaching and with the experiences of faith-based development agencies. Particular attention is given to the work of Gustavo Gutiérrez and Pope Paul VI’s document, Populorum Progressio. The article will illustrate the ways that liberation theology has challenged Catholic Social Teaching in its thinking about how to respond to economic marginalization, insisting that charitable aid is insufficient and highlighting the difference between “development” and “liberation.”
Effects of an Interteaching Probe on Learning and Generalization of American Psychological Association (APA) Style
Authors: Slezak Jonathan M. , Faas Caitlin
Published: February 2017

This study implemented the components of interteaching as a probe to teach American Psychological Association (APA) Style to undergraduate university students in a psychology research methods and statistics course. The interteaching method was compared to the traditional lecture-based approach between two sections of the course with the same instructor. Both teaching strategies significantly increased student performance on the APA Style knowledge relative to pretest performance, with a greater average increase and larger effect size for students exposed to interteaching methods. However, 2 months after the initial intervention, the application of APA Style knowledge to a draft of a research report resulted in no significant differences. Future research is warranted to determine conditions that result in enhanced generalization and retention of APA Style knowledge.
Coverage of Rosenhan’s “On Being Sane in Insane Places” in Abnormal Psychology Textbooks
Authors: Bartels Jared M. , Peters Daniel
Published: February 2017

The present study examined 12 abnormal psychology textbooks to determine whether Rosenhan’s classic study, “Being sane in insane places,” was covered, and if so, the nature of that coverage. Only 50% covered the study, with all describing the study as demonstrating the biasing power of psychiatric labels. Two key aspects of the study (the diagnoses of schizophrenia and their supposed subsequent influence on the hospital staff’s perception of the pseudopatients’ normal behavior as pathological) were commonly discussed. However, although the study has been heavily criticized, only two texts discussed any criticism of it. Teachers and text authors are urged to become more familiar with the critical literature on this study, and suggestions for class discussions of the study are provided.
Polemical and theatrical translation in interludes
Authors: Happé Peter
Published: February 2017

This article examines changes to source texts of three English interludes: the anonymous Everyman, John Heywood’s Johan Johan, and Jack Juggler (attributed to Nicholas Udall). It considers the differing religious contexts for each and addresses theatrical contexts of the originals and those to which they are moved. While each contains detailed word to word translation, aspects of language, religion and political contexts reveal new emphases. The work of others is substantially nuanced in the new versions, and in different ways changes to each of these plays may contribute to our understanding of the conscious and unconscious processes of translation.
Validation of an automatic reference region extraction for the quantification of [18F]DPA-714 in dynamic brain PET studies
Authors: García-Lorenzo Daniel , Lavisse Sonia , Leroy Claire , Wimberley Catriona , Bodini Benedetta , Remy Philippe , Veronese Mattia , Turkheimer Federico , Stankoff Bruno , Bottlaender Michel
Published: February 2017

There is a great need for a non-invasive methodology enabling the quantification of translocator protein overexpression in PET clinical imaging. [18F]DPA-714 has emerged as a promising translocator protein radiotracer as it is fluorinated, highly specific and returned reliable quantification using arterial input function. Cerebellum gray matter was proposed as reference region for simplified quantification; however, this method cannot be used when inflammation involves cerebellum. Here we adapted and validated a supervised clustering (supervised clustering algorithm (SCA)) for [18F]DPA-714 analysis. Fourteen healthy subjects genotyped for translocator protein underwent an [18F]DPA-714 PET, including 10 with metabolite-corrected arterial input function and three for a test–retest assessment. Two-tissue compartmental modelling provided [Formula: see text] estimates that were compared to either [Formula: see text] or [Formula: see text] generated by Logan analysis (using supervised clustering algorithm extracted reference region or cerebellum gray matter). The supervised clustering algorithm successfully extracted a pseudo-reference region with similar reliability using classes that were defined using either all subjects, or separated into HAB and MAB subjects. [Formula: see text], [Formula: see text] and [Formula: see text] were highly correlated (ICC of 0.91 ± 0.05) but [Formula: see text] were ∼26% higher and less variable than [Formula: see text]. Reproducibility was good with 5% variability in the test–retest study. The clustering technique for [18F]DPA-714 provides a simple, robust and reproducible technique that can be used for all neurological diseases.
Everyday experiences of post-politicising processes in rural freshwater management
Authors: Thomas Amanda C
Published: February 2017

There has been a burgeoning of geography literature that draws on post-politics to make sense of trends in Western liberal democracies. This body of literature argues that consensus is constructed around capitalism, and spaces for dissensus are closed off. However, critiques have focused on the state-centric and totalising nature of some of this literature. This article adds nuance and depth to explorations of post-politicising processes. I do this through an empirical case study that demonstrates how dissensus is disavowed through the construction of community, and highlights gendered and classed experiences of this disavowal. In exploring a rural community in Aotearoa New Zealand engaged in catchment-based decision making, I draw on Nancian critical community scholarship to analyse how neoliberal and rural discourses defined belonging. Boundaries, and who could access the catchment committee, were shaped by expectations of economic consumption, spatial membership, gendered behavioural norms and class. The policing of these boundaries became increasingly antagonistic to the point of threats of violence. Accounts by those who experienced this policing demonstrate the embodied and largely banal nature of post-politicising processes. And yet, this case study illustrates how efforts to depoliticise are entangled with politicisation and raises questions about how change unfolds.
Exploring the work–life challenges and dilemmas faced by managers and professionals who live alone
Authors: Wilkinson Krystal , Tomlinson Jennifer , Gardiner Jean
Published: February 2017

This article aims to question the dominant understanding of work–life balance or conflict as primarily a ‘work–family’ issue. It does this by exploring the experiences of managers and professionals who live alone and do not have children – a group of employees traditionally overlooked in work–life policy and research but, significantly, a group on the rise within the working age population. Semi-structured interviews with 36 solo-living managers and professionals were carried out in the UK, spanning a range of occupations. In addition to previously identified work–life issues, four themes emerged that were pressing for and specific to solo-living managers and professionals. These are articulated here as challenges and dilemmas relating to: assumptions about work and non-work time; the legitimacy of their work–life balance; lack of support connected to financial and emotional well-being; and work-based vulnerabilities.
Rotor profile design and numerical analysis of 2–3 type multiphase twin-screw pumps
Authors: Yan Di , Tang Qian , Kovacevic Ahmed , Rane Sham , Pei Linqing
Published: February 2017

Increasing demands for high-performance handling of fluids in oil and gas as well as other applications require improvements of efficiency and reliability of screw pumps. Rotor profile plays the key role in the performance of such machines. This paper analyses difference in performance of 2–3 lobe combination of twin-screw pumps with different rotor profiles. A-type profile formed of involute–cycloid curves and D-type formed of cycloid curves are typical representatives for 2–3 type screw pumps. The investigation is performed by use of a full 3-D computational fluid dynamics analysis based on a single-domain structured moving mesh obtained by novel grid generation procedure. The real-time mass flow rate, rotor torque, pressure distribution and velocity field were obtained from 3D computational fluid dynamics calculations. The performance curves were produced for variable rotation speeds and variable discharge pressures. The computational fluid dynamics model was validated by comparing the simulation results of the A-type pump with the experimental data. In order to get the performance characteristics of D-type profile, two rotors with D-type profile were designed. The first has the same displacement volume as A-type while the second has the same lead and rotor length as A-type but different displacement volume. The comparison of results obtained with two rotor profiles gave an insight on the advantages and disadvantages of each of them.
Out-of-pocket Payments for Healthcare in India
Authors: Hooda Shailender Kumar
Published: February 2017

This paper examines the impact of out-of-pocket (OOP) health payment on impoverishment of poorest households using unit-level records of latest (68th: 2011–2012) round data of National Sample Survey Organisation (NSSO). This is examined by estimating the prevalence, intensity and incidence of catastrophic health payments across different economic stratum households, rural-urban residents and states. Estimates show that high OOP expenditure on healthcare has serious repercussions for households’ well-being in India, as it plunges a sizeable section of the society even the well-off to abysmal poverty levels. It pushes 3.5 per cent (50.6 million) people below poverty line and also causes further deepening of poverty for already poor people. The rural, lowest above poverty line (APL) quintile and households from low-income states (like Uttar Pradesh and Bihar) experienced a large increase in poverty headcounts and poverty deepening impacts. Any health policy initiative directed towards these groups and regions may lower down the catastrophic burden.
Employment structures, employee attitudes and workplace resistance in neoliberal Poland
Authors: Żuk Piotr
Published: February 2017

During the past quarter century of neoliberal social, economic and political upheaval in Poland, the structure of workplaces has changed, and so have changes in worker attitudes to workplace and social solidarity. This article explores the links between changes to organisational and employment structures and shifts in worker attitudes, focusing on the implications of attitudinal shifts for the capacity for organised workplace resistance. It documents a loss of collective identity and a growth of individualism and social distrust. The analysis is based on publicly available economic and social statistics and the author’s own qualitative and quantitative research, drawn in part from computer-aided interviews in de-industrialising Lower Silesia. Evidence is provided that the extent and intensity of attitudinal shifts have varied according to changed workplace structures, based on privatisation and organisational size, and especially on the accompanying changes in workplace culture and climate. Increased individualism, based on formal decollectivisation, has been accompanied by attitudinal individualism and distrust of other people and social institutions. As a result, declining capacity for workplace resistance and an increased sense of powerlessness have increased workers’ susceptibility to right-wing propaganda.
Health-Related Quality of Life of Patients With Diabetes and Foot Ulcers
Authors: Evans Andrew R. , Pinzur Michael S.
Published: February 2017

Thirty-four patients with diabetes who attended a university diabetic foot clinic for treatment of a foot ulcer completed the American Academy of Orthopaedic Surgeons Musculoskeletal Outcomes Measure. The purpose of the study was to measure the impact of foot ulcers in patients with diabetes on the physical, mental, emotional, and social aspects of patients' lives. Thirty had at least a high school education. Only six were employed at the time. Nineteen were retired or disabled due to poor health. Sixteen were obese, 10 were considered overweight, and eight had a BMI within the acceptable range. Subjects had an average of four to five bodily systems affected by comorbid illness for which they were receiving treatment, some of which limited their activities. Approximately 85% of the study population required some type of ambulatory assist device or were unable to ambulate independently. The study population was significantly limited in performing all physical activities, especially those requiring use of the foot and ankle, and viewed their own health as being significantly worse than that of the general population. All stated that their foot/ankle disease interfered with their lives. Pain was not a significant component of their disability. The results of this study confirm the hypothesis that foot ulcers in patients with diabetes have a negative impact on quality of life in affected individuals.
Heteronormativity made me lesbian: Femme, butch and the production of sexual embodiment projects
Authors: Crawley Sara L , Willman Rebecca K
Published: February 2017

Queer theory argues that ruling heteronormative discourses are productive of sexualities. How then does heteronormativity produce lesbians? We theorize femme and butch as sexual embodiment projects—processual, relational responses to patriarchal heteronormativity incessantly textually threaded throughout our lives. Drawing on radical feminisms updated with Foucault and Dorothy Smith, we offer autoethnographic accounts of our sexual embodiments of butch and femme, arguing not that rape experiences, but the constant threat of rape in everyday life can produce lesbian desire and embodiment. Ultimately, we understand sexual embodiment as not based on a fixed ontological ground but always in the relational, everyday doings of people and, hence, malleable within the social context, discursive moment, and individual intersections of one’s life within relations of power (gender, race, class, religiosity, nationality, and so on).
On being wronged and being wrong
Authors: Slavny Adam
Published: February 2017

If D commits a wrong against V, D typically incurs a corrective duty to V. But how should we respond if V has false beliefs about whether she is harmed by D’s wrong? There are two types of cases we must consider: (1) those in which V is not harmed but she mistakenly believes that she is (2) those in which V is harmed but she mistakenly believes that she is not. I canvass three views: The Objective View, The Subjective View and The Mixed View. The Objective View holds that V’s claim depends on the correct account of harm, rather than her false beliefs, and so D has a duty to offer damages to V in (2) but not in (1) in order to compensate her. The Subjective View holds that, for broadly anti-perfectionist reasons, V’s claim depends on her sincere beliefs, even if they are mistaken, and so D has a duty to compensate V in (1) but not in (2). The Mixed View holds that we should defer to her beliefs in (1) but not in (2), so D has a duty to compensate her in both cases. In this article, I argue that we should accept The Mixed View.
Functional regression models: Some directions of future research
Authors: Paganoni Anna Maria , Sangalli Laura M.
Published: February 2017

We congratulate the authors for their excellent work that provides a clear overview of the large and now mature field of regression models for functional data. We here complement their discussion indicating some directions of further research that we deem particularly important.
Inhibition of Rho kinase protects from ischaemia–reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes
Authors: Tratsiakovich Yahor , Kiss Attila , Gonon Adrian T , Yang Jiangning , Sjöquist Per-Ove , Pernow John
Published: February 2017

Aim:

RhoA/Rho-associated kinase and arginase are implicated in vascular complications in diabetes. This study investigated whether RhoA/Rho-associated kinase and arginase inhibition protect from myocardial ischaemia–reperfusion injury in type 1 diabetes and the mechanisms behind these effects.

Methods:

Rats with streptozotocin-induced type 1 diabetes and non-diabetic rats were subjected to 30 min myocardial ischaemia and 2 h reperfusion after being randomized to treatment with (1) saline, (2) RhoA/Rho-associated kinase inhibitor hydroxyfasudil, (3) nitric oxide synthase inhibitor NG-monomethyl-l-arginine monoacetate followed by hydroxyfasudil, (4) arginase inhibitor N-omega-hydroxy-nor-l-arginine, (5) NG-monomethyl-l-arginine monoacetate followed by N-omega-hydroxy-nor-l-arginine or (6) NG-monomethyl-l-arginine monoacetate given intravenous before ischaemia.

Results:

Myocardial arginase activity, arginase 2 expression and RhoA/Rho-associated kinase activity were increased in type 1 diabetes ( p < 0.05). RhoA/Rho-associated kinase inhibition and arginase inhibition significantly reduced infarct size in diabetic and non-diabetic rats ( p < 0.001). The cardioprotective effects of hydroxyfasudil and N-omega-hydroxy-nor-l-arginine in diabetes were abolished by nitric oxide synthase inhibition. RhoA/Rho-associated kinase inhibition attenuated myocardial arginase activity in diabetic rats via a nitric oxide synthase–dependent mechanism.

Conclusion:

Inhibition of either RhoA/Rho-associated kinase or arginase protects from ischaemia–reperfusion injury in rats with type 1 diabetes via a nitric oxide synthase–dependent pathway. These results suggest that inhibition of RhoA/Rho-associated kinase and arginase constitutes a potential therapeutic strategy to protect the diabetic heart against ischaemia–reperfusion injury.
A New COL3A1 Mutation in Ehlers-Danlos Syndrome Vascular Type With Different Phenotypes in the Same Family
Authors: Cortini Francesca , Marinelli Barbara , Romi Silvia , Seresini Agostino , Pesatori Angela Cecilia , Seia Manuela , Montano Nicola , Bassotti Alessandra
Published: February 2017

Vascular Ehlers-Danlos syndrome (vEDS) is a rare and severe connective tissue disorder caused by mutations in the collagen type III alpha I chain ( COL3A1) gene. We describe a pathogenetic heterozygous COL3A1 mutation c.3140 G>A, p. Gly1047Asp, identified using next-generation sequencing, in a 40-year-old Italian female. The genetic test performed on her relatives, which present different clinical phenotypes, confirmed that they carry the same mutation in heterozygous state. This finding confirms that mutations causing vEDS have an incomplete penetrance.
The effects of citizenship and ethnicity on the education pathways of Pacific youth in Australia
Authors: Kearney Judith , Glen Matthew
Published: February 2017

This article reports on a study that investigated the education pathways of 464 young people. We were interested in the effects of New Zealand citizenship and Pacific ethnicity on pathways so compared findings for three groups residing in Australia: Pacific youth with New Zealand citizenship, Pacific youth with Australian citizenship, and non-Pacific youth with Australian citizenship. Findings showed that the first group was significantly less likely than others to have gained a university qualification. Pacific youth, regardless of citizenship, were more likely than non-Pacific peers to have a vocational qualification rather than a university qualification. No evidence suggests this resulted from lack of motivation or lack of ability. However, two inter-related factors explained outcomes for the Pacific cohort: likelihood of low socio-economic status and first-in-family to attend university. We propose that Pacific communities’ collectivist orientation may also restrict opportunities for Pacific youth seeking higher education pathways. We therefore argue that until Pacific young people are better represented in higher education cohorts, they should be a targeted equity group, and that the Australian government’s decision to exclude many of these young people from higher education loans is an anomaly in the context of its ‘widening participation’ agenda for Australian higher education.
Malignant Posterior Reversible Encephalopathy Syndrome—An Exacting Challenge for Neurocritical Care Physicians
Authors: Magsi Shahvaiz , Zafar Atif
Published: February 2017

We report a case of malignant posterior reversible encephalopathy syndrome (PRES) in a 62-year-old Caucasian female with a complex medical history and comorbidities admitted for bowel resection and lysis of iatrogenic bowel adhesions and enterocutaneous fistulas. Postoperatively, the patient developed sudden bilateral visual loss with no other neurologic deficits. Computed tomography scan showed very severe PRES-like changes, confirmed on magnetic resonance imaging (MRI). Systolic blood pressure remained around 170 mm HG. The patient was obtunded and remained unresponsive after MRI, with minimal response and a deteriorating clinical condition. The patient was given hyperosmolar therapy with a mannitol bolus. She recovered well with near resolution of imaging findings.
Social Interactions and Cultural Repertoires as Resources for Coping With Breast Cancer
Authors: Zucchermaglio Cristina , Alby Francesca
Published: February 2017

The article aims to better understand the role of cultural and social resources for coping with cancer as a disruptive experience. Fourteen women who had recently received a diagnosis of breast cancer and started a treatment in an Italian hospital have been interviewed individually to elicit narratives regarding the interactions with the other patients. The analysis focused on the role played by social interactions and cultural repertoires as devices for making sense of and facing the illness. Results show that patients use both interactive as well as noninteractive strategies. In both cases, however, the other patients are an important reference in the interviewees’ accounts. Even for noninteracting patients, the others and specific groups are taken into account and displayed in their narratives either directly or indirectly (i.e., typified or imagined), contributing to interpret and address what they experienced as cancer patients. Moreover, results provide empirical evidence of the various cultural repertoires (including examples retraceable to popular culture) on which people rely to address and cope with the illness. These results widen the individualistic framework commonly used in the understanding of coping strategies by including psychosocial phenomena that are created outside the individual in the complex interactions with the social and cultural world.
Making It All Work
Authors: Thomas Annie , Ashcraft Alyce S. , Owen Donna C. , Conway-Phillips Regina
Published: February 2017

The greater prevalence of type 2 diabetes is a critical issue among the U.S. Hispanic population. This study examined the struggles of Hispanic adults managing type 2 diabetes with limited resources. Ten Hispanic adults (enrolled in a larger study to determine the effects of diabetes self-management intervention), 25 to 80 years of age and living in a rural West Texas county in the United States, were selected. Three categories of challenges emerged: (a) diabetes self-care behaviors and challenges, (b) challenges with limited resources, and (c) challenges with support mechanisms. “Making it all work” was the overarching theme that tied all the categories together. This study offers lessons for health care providers and policymakers on how to maximize the availability of resources for Hispanic individuals with type 2 diabetes living within the constraints of limited resources.
Bedside Interprofessional Rounding
Authors: Burdick Kailee , Kara Areeba , Ebright Patricia , Meek Julie
Published: February 2017

Background:

Bedside interprofessional rounding is gaining ground as a means to improve collaboration and patient outcomes, yet little is known regarding patients’ perceptions of the practice.

Methods:

This descriptive study used individual patient interviews to elicit views on interprofessional rounding from 35 patients at a large, urban hospital.

Results:

The findings identified three major categories: 1) about the rounding process; 2) clinical information; and 3) the impact/value of bedside inter-professional rounding.

Discussion:

Intentionally eliciting and responding to our patients’ views of interprofessional rounding may help us design methods that are patient centered and effective.
Improving the Patient Experience by Implementing an ICU Diary for Those at Risk of Post-intensive Care Syndrome
Authors: Blair K Taylor A , Eccleston Sarah D , Binder Hannah M , McCarthy Mary S
Published: February 2017

The critical care literature in the US has recently brought attention to the impact an ICU experience can have long after the patient survives critical illness, particularly if delirium was present. Current recommendations to mitigate post-intensive care syndrome (PICS) are embedded in patient and family-centered care and aim to promote family presence in the ICU, provide support for decision-making, and enhance communication with the health-care team. Evidence-based interventions are few in number but include use of an ICU diary to minimize the psychological and emotional sequelae affecting patients and family members in the months following the ICU stay. In this paper we describe our efforts to implement an ICU diary and solicit feedback on its role in fostering teamwork and communication between patients, family members, and ICU staff. Next steps will involve a PICS follow-up clinic where trained staff will coordinate specialty referrals and perform long-term monitoring of mental health and other quality of life outcomes.
Granulocyte colony-stimulating factor mobilizes dormant hematopoietic stem cells without proliferation in mice
Authors: Bernitz Jeffrey M. , Daniel Michael G. , Fstkchyan Yesai S. , Moore Kateri
Published: February 2017

Key Points

G-CSF mobilizes dormant HSCs without proliferation. Transplantation defects of mobilized peripheral blood-derived hematopoietic stem and progenitor cells are divisional history independent.
Runx transcription factors in the development and function of the definitive hematopoietic system
Authors: de Bruijn Marella , Dzierzak Elaine
Published: February 2017

The Runx family of transcription factors (Runx1, Runx2, and Runx3) are highly conserved and encode proteins involved in a variety of cell lineages, including blood and blood-related cell lineages, during developmental and adult stages of life. They perform activation and repressive functions in the regulation of gene expression. The requirement for Runx1 in the normal hematopoietic development and its dysregulation through chromosomal translocations and loss-of-function mutations as found in acute myeloid leukemias highlight the importance of this transcription factor in the healthy blood system. Whereas another review will focus on the role of Runx factors in leukemias, this review will provide an overview of the normal regulation and function of Runx factors in hematopoiesis and focus particularly on the biological effects of Runx1 in the generation of hematopoietic stem cells. We will present the current knowledge of the structure and regulatory features directing lineage-specific expression of Runx genes, the models of embryonic and adult hematopoietic development that provide information on their function, and some of the mechanisms by which they affect hematopoietic function.
The clinical spectrum of Erdheim-Chester disease: an observational cohort study
Authors: Estrada-Veras Juvianee I. , O’Brien Kevin J. , Boyd Louisa C. , Dave Rahul H. , Durham Benjamin H. , Xi Liqiang , Malayeri Ashkan A. , Chen Marcus Y. , Gardner Pamela J. , Alvarado Enriquez Jhonell R. , Shah Nikeith , Abdel-Wahab Omar , Gochuico Bernadette R. , Raffeld Mark , Jaffe Elaine S. , Gahl William A.
Published: February 2017

Key Points

ECD varies in terms of age of onset, clinical presentation, manifestations, organ involvement, disease severity, and survival. ECD is a neoplasm and should be adopted by the field of hematology-oncology following the World Health Organization reclassification.
Inherited and Uncommon Causes of Stroke
Authors: Majersik Jennifer Juhl
Published: February 2017

Purpose of Review: This article is a practical guide to identifying uncommon causes of stroke and offers guidance for evaluation and management, even when large controlled trials are lacking in these rarer forms of stroke.

Recent Findings: Fabry disease causes early-onset stroke, particularly of the vertebrobasilar system; enzyme replacement therapy should be considered in affected patients. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), often misdiagnosed as multiple sclerosis, causes migraines, early-onset lacunar strokes, and dementia. Moyamoya disease can cause either ischemic or hemorrhagic stroke; revascularization is recommended in some patients. Cerebral amyloid angiopathy causes both microhemorrhages and macrohemorrhages, resulting in typical stroke symptoms and progressive dementia. Pregnancy raises the risk of both ischemic and hemorrhagic stroke, particularly in women with preeclampsia/eclampsia. Pregnant women are also at risk for posterior reversible encephalopathy syndrome (PRES), reversible cerebral vasoconstriction syndrome, and cerebral venous sinus thrombosis. Experts recommend that pregnant women with acute ischemic stroke not be systematically denied the potential benefits of IV recombinant tissue plasminogen activator.

Summary: Neurologists should become familiar with these uncommon causes of stroke to provide future risk assessment and family counseling and to implement appropriate treatment plans to prevent recurrence.
Acumulação de capacidades tecnológicas, inovação e competitividade industrial: alguns resultados para a Indústria Brasileira de Petróleo e Gás
Authors: Pinheiro Maurício Canêdo , Figueiredo Paulo N. , Perin Fernanda Steiner , Cabral Bernardo Pereira , Silva Felipe Queiroz , Wegner Rubia Cristina
Published: February 2017

O desenvolvimento industrial e tecnológico é um dos fatores decisivos para que os países avancem para a categoria de alta renda per capita. Não se trata de uma panaceia, mas a história ensina que nações que se desenvolveram industrialmente, por meio da Acumulação de Capacidades Tecnológicas (ACT) para inovação, também obtiveram significativo desenvolvimento socioeconômico. Tornaram-se países de alta renda, transformaram-se em líderes no mercado global e em fornecedores de tecnologia para vários tipos de indústria.A indústria tem um importante papel de viabilizar um ritmo adequado de crescimento econômico por ser indutora e difusora de inovações tecnológicas, ter crescimento da produtividade superior ao dos outros setores e ser demandante de recursos humanos qualificados que têm efeitos multiplicadores na economia. Além disso, sendo o setor intermediário, tem a capacidade de proporcionar o encadeamento produtivo. Portanto, o fortalecimento da capacidade tecnológica da indústria brasileira é uma das condições necessárias ao crescimento econômico do país.Buscando contribuir para o aumento de competitividade da indústria brasileira, este documento, integrante de um projeto de pesquisa mais amplo3, objetiva examinar como as ACT inovadoras, em nível de empresas e setores industriais, pode contribuir para fortalecer a competitividade industrial do país.
A very simple, re-executable neuroimaging publication
Authors: Ghosh Satrajit S. , Poline Jean-Baptiste , Keator David B. , Halchenko Yaroslav O. , Thomas Adam G. , Kessler Daniel A. , Kennedy David N.
Published: February 2017

Reproducible research is a key element of the scientific process. Re-executability of neuroimaging workflows that lead to the conclusions arrived at in the literature has not yet been sufficiently addressed and adopted by the neuroimaging community. In this paper, we document a set of procedures, which include supplemental additions to a manuscript, that unambiguously define the data, workflow, execution environment and results of a neuroimaging analysis, in order to generate a verifiable re-executable publication. Re-executability provides a starting point for examination of the generalizability and reproducibility of a given finding.
A double blinded, placebo-controlled pilot study to examine reduction of CD34+/CD117+/CD133+ lymphoma progenitor cells and duration of remission induced by neoadjuvant valspodar in dogs with large B-cell lymphoma
Authors: Ito Daisuke , Childress Michael , Mason Nicola , Winter Amber , O’Brien Timothy , Henson Michael , Borgatti Antonella , Lewellen Mitzi , Krick Erika , Stewart Jane , Lahrman Sarah , Rajwa Bartek , Scott Milcah C , Seelig Davis , Koopmeiners Joseph , Ruetz Stephan , Modiano Jaime
Published: February 2017

We previously described a population of lymphoid progenitor cells (LPCs) in canine B-cell lymphoma defined by retention of the early progenitor markers CD34 and CD117 and “slow proliferation” molecular signatures that persist in the xenotransplantation setting. We examined whether valspodar, a selective inhibitor of the ATP binding cassette B1 transporter (ABCB1, a.k.a., p-glycoprotein/multidrug resistance protein-1) used in the neoadjuvant setting would sensitize LPCs to doxorubicin and extend the length of remission in dogs with therapy naïve large B-cell lymphoma. Twenty dogs were enrolled into a double-blinded, placebo controlled study where experimental and control groups received oral valspodar (7.5 mg/kg) or placebo, respectively, twice daily for five days followed by five treatments with doxorubicin 21 days apart with a reduction in the first dose to mitigate the potential side effects of ABCB1 inhibition. Lymph node and blood LPCs were quantified at diagnosis, on the fourth day of neoadjuvant period, and 1-week after the first chemotherapy dose. Valspodar therapy was well tolerated. There were no differences between groups in total LPCs in lymph nodes or peripheral blood, nor in event-free survival or overall survival. Overall, we conclude that valspodar can be administered safely in the neoadjuvant setting for canine B-cell lymphoma; however, its use to attenuate ABCB1+ cells does not alter the composition of lymph node or blood LPCs, and it does not appear to be sufficient to prolong doxorubicin-dependent remissions in this setting.
Cost-Effective Quality Assurance in Crowd Labeling
Authors: Wang Jing , Ipeirotis Panagiotis G. , Provost Foster
Published: February 2017

The emergence of online paid micro-crowdsourcing platforms, such as Amazon Mechanical Turk, allows on-demand and at-scale distribution of tasks to human workers around the world. In such settings, online workers come and complete small tasks posted by employers, working for as long or as little as they wish, a process that eliminates the overhead of hiring (and dismissal). This flexibility introduces a different set of inefficiencies: verifying the quality of every submitted piece of work is an expensive operation that often requires the same level of effort as performing the task itself. A number of research challenges arise in such settings. How can we ensure that the submitted work is accurate? What allocation strategies can be employed to make the best use of the available labor force? How can we appropriately assess the performance of individual workers? In this paper, we consider labeling tasks and develop a comprehensive scheme for managing the quality of crowd labeling: First, we present several algorithms for inferring the true classes of objects and the quality of participating workers, assuming the labels are collected all at once before the inference. Next, we allow employers to adaptively decide which object to assign to the next arriving worker and propose several heuristic-based dynamic label allocation strategies to achieve the desired data quality with significantly fewer labels. Experimental results on both simulated and real data confirm the superior performance of the proposed allocation strategies over other existing policies. Finally, we introduce two novel metrics that can be used to objectively rank the performance of crowdsourced workers after fixing correctable worker errors and taking into account the costs of different classification errors. In particular, the worker value metric directly measures the monetary value contributed by each label of a worker toward meeting the quality requirements and provides a basis for the design of fair and efficient compensation schemes.

The online appendix is available at https://doi.org/10.1287/isre.2016.0661 .
Sequestration of Catechol and Pentachlorophenol by Mechanochemically Treated Kaolinite
Authors: Ancona Valeria , Di Leo Paola , Pizzigallo Maria Donata Rosa
Published: February 2017

The pollution of soils by organic contaminants, such as phenols, is a serious problem because of the high toxicity and persistence in the environment. Mechanochemical treatments (MTs) of polluted soils with minerals, such as clays and oxides, which have surfaces that exhibit catalytic properties, have been suggested to be a new useful strategy to promote both organic and inorganic pollutant degradation. Nevertheless, much still remains to be studied about the capability of clays to promote pollutant removal by means of the mechanochemical activation of the mineral surfaces. This work investigates the efficiency of the mineral kaolinite in promoting the sequestration of catechol (CAT) and pentachlorophenol (PCP) by MT. A well crystallized kaolinite (KGa-1b) was milled for prolonged times with different amounts of organic molecules so as to obtain two different clay:organic compound ratios. Prolonged grinding and a higher clay mineral:organic compound ratio were found to be more effective in promoting a stronger removal than simple contact. After 1 h of mechanochemical treatment, the PCP and CAT removal percentages were 32% and 20%, respectively. Additionally, a 7-day undisturbed incubation of the milled mixtures produced a trend for increased CAT removal (up to 40%). The interaction mechanism between kaolinite and each organic compound (i.e. CAT and PCP) after a MT was inferred by integrating information from spectroscopic, diffractometric, and chromatographic analyses. X-ray diffraction and Fourier-transform infrared data suggested a strong interaction between CAT and KGa-1b. This interaction mechanism likely occurs through the formation of an inner-sphere complex by H-bonding between the organic molecules and the oxygens of the kaolinite tetrahedral sheet. On the other hand, a weak interaction (i.e. van der Waals type) can occur between the KGa-1b O-planes and the PCP molecules, which likely bind to the external surfaces of KGa-1b.
Applying the Universal Design for Learning Framework for Individuals With Intellectual Disability: The Future Must Be Now
Authors: Smith Sean J. , Lowrey K. Alisa
Published: February 2017

The current research in Universal Design for Learning (UDL) for students with intellectual disability (ID) is briefly summarized and considered in light of the national goals presented by the American Association on Intellectual and Developmental Disabilities (AAIDD) in this article. Additionally, an action plan is provided for researchers and practitioners to extend knowledge on the implementation of the UDL framework inclusive of individuals with ID.
Closed-Tube PCR with Nested Serial Invasion Probe Visualization Using Gold Nanoparticles
Authors: Wang Jianping , Zou Bingjie , Ma Yinjiao , Ma Xueping , Sheng Nan , Rui Jianzhong , Shao Yang , Zhou Guohua
Published: February 2017

BACKGROUND

Detecting DNA biomarkers related to personalized medicine could improve the outcome of drug therapy. However, personalized medicine in a resource-restrained hospital is very difficult because DNA biomarker detection should be performed by well-trained staff and requires expensive laboratory facilities.

METHODS

We developed a gold nanoparticle–based “Tube-Lab” to enable DNA analysis in a closed tube. Gold nanoparticle–modified probes (GNPs) were used to construct an inexpensive and simple DNA sensor for signal readout. The method consists of 3 steps (template amplification, sequence identification, and GNP-based signal readout), bridged by an invasive reaction. With temperature control at each step, the 3 reactions proceed sequentially and automatically in a closed tube without any liquid transfer. We used Tube-Lab to detect different biomarkers in blood, tissue, and plasma, including US Food and Drug Administration–approved pharmacogenomic biomarkers (single nucleotide polymorphisms, somatic mutations).

RESULTS

The combination of PCR-based template replication and invader-based signal amplification allowed detection of approximately 6 copies of input DNA and the selective pick up 0.1% mutants from large amounts of background DNA. This method highly discriminated polymorphisms and somatic mutations from clinical samples and allowed a “liquid biopsy” assay with the naked eye.

CONCLUSIONS

Tube-Lab provides a promising and cost-effective approach for DNA biomarker analysis, including polymorphisms and somatic mutations from blood DNA, tissue DNA, or circulating tumor DNA in plasma, which are critical for personalized medicine.
The magic of internet protocol
Authors: Batiha Khaldoun
Published: February 2017

As the developing use of web and intranet keep on expanding colossally, the issue to suit more clients and gadgets has been risen. Subsequently, a location range must be required to oblige the hurry. Sadly, IPv4 address region and alternatives are insufficient to meet this new necessity. A fresh out of the box new Protocol is expected to satisfy the developing interest. IPv6 is the best response to the above issues. We should have an early on study on IPv6 convention. IPv6 convention offers verity of advantages that incorporates a more extensive location region and upgraded choices and changes that are not beforehand be found in the IPv4. IPv6 in contrast with IPv4 have a wide address range, simple documentations for representation of a location, enhanced administrations and alternatives, upgraded header, propelled highlights, new choices and bolster, auto setup highlight, new convention bolster, Network Security, Virus and Worms Security, Support for different Operating frameworks and stage including Microsoft windows, Linux and MAC.
O ENSINO DAS ESTRATÉGIAS DE COMPREENSÃO LEITORA: UMA PROPOSTA COM LIVROS DE LITERATURA INFANTIL
Authors: Da Silva Joice Ribeiro Machado , Souza Renata Junqueira de
Published: February 2017

O presente artigo objetiva apresentar os resultados da tese defendida em 2014 no PPGE da UNESP – Presidente Prudente. O problema central da pesquisa consistiu em mostrar como um trabalho sistematizado sobre o ensino das estratégias de leitura contribuiu para o avanço na compreensão do texto literário. A metodologia utilizada constou de pesquisa teórica e pesquisa-ação, aplicada em uma turma de 5º ano do Ensino Fundamental de uma escola pública municipal da cidade de Marília/SP em 2011, na qual atuei como professora da turma. Os resultados revelam que a incorporação adequada das estratégias de compreensão contribuiu para a formação do leitor estratégico. Dentre as sete estratégias ensinadas destacam-se as apropriadas pelas crianças: conhecimento prévio, conexões, inferências e questões ao texto. A pesquisa colaborou também com a ampliação do acervo literário das crianças e com o desenvolvimento do gosto pela leitura de literatura infantil.
O PROCESSO DE SEMIFORMAÇÃO NA EDUCAÇÃO: REFLEXÕES POSSÍVEIS E NECESSÁRIAS NA RELAÇÃO INFÂNCIA E INDÚSTRIA CULTURAL.
Authors: Silva Anilde Tombolato Tavares da
Published: February 2017

Este artigo insere-se num panorama contemporâneo que embasa a essência da infância permeada pela indústria cultural buscando problematizar sua correlação entre a produção de saberes culturais fragmentados que refletem na semiformação e numa pedagogia parcializada na escola contemporânea. Amparados pelo pensamento de Max Horkheimer  e Theodor Adorno buscamos lançar um olhar mais atento e crítico para a educação contemporânea que sob a égide da bandeira da formação do indivíduo crítico e transformador,  submete-se passivamente ao processo de semiformação e conformação diante dos encantos que se produzem através da Indústria Cultural. Desta forma, confrontar os desafios postos no campo da educação e da prática educativa, os limites e a possibilidade de se assumir a escola como espaço de produção do novo, do não dito, do não pensado em detrimento do que já está instituído.
SÓCRATES, IVAN ILITCH E A EXPERIÊNCIA DO PENSAR FILOSÓFICO
Authors: Miranda José Valdinei Albuquerque
Published: February 2017

Resumo: Este trabalho tem por objetivo discutir a experiência do pensar filosófico a partir da obra A morte de Ivan Ilitch de Lev Tolstoi e Apologia de Sócrates de Platão.  Com estilos diferentes, esses escritos abordam o tema da experiência filosófica, tendo como horizonte de análise a proximidade da morte. Portanto, encontramos nestas duas experiências, um pensar filosófico que se volta para problematizar o sentido da vida em um tempo de proximidade da morte. A experiência de Ivan Ilitch direciona-se a uma profunda análise filosófica de sua existência, permitindo colocar em questão a condição de liberdade e aprisionamento do homem moderno, enquanto que a experiência filosófica de Sócrates nos deixa como herança a sua autêntica preocupação ética com a formação dos jovens atenienses e o valor de uma vida justificada filosoficamente.