bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathogenesis‐Guided Engineering: pH‐Responsive Imprinted Polymer Co‐Delivering Folate for Inflammation‐Resolving as Immunotherapy in Implant‐Related Infections
Authors: Costa Raphael C. , Nagay Bruna E. , Villa Javier E. L. , Sotomayor Maria D. P. T. , Neres Lariel Chagas da Silva , Benso Bruna , Aguayo Sebastian , Sacramento Catarina M. , Ruiz Karina G. S. , Spada Fernanda P. , de Avila Erica Dorigatti , da Costa Monique G. , Faverani Leonardo P. , Cintra Luciano T. A. , Souza Joāo Gabriel S. , Barão Valentim A. R.
Published: July 2024

Folate (FT) is a suitable targeting ligand for folate receptors (FOLR) overexpressed on inflamed cells. Thus, FT‐loaded polymers can be used as FOLRs‐targeted immunotherapy to positively modulate the inflammatory process. A novel biodegradable imprinted polymer with a FT delivery mechanism driven by pH changes [PCL‐MIP@FT] is designed with molecularly imprinted technology. The pH mechanism is validated in vitro, demonstrating that an acidic environment accelerated and increased the release of FT for a period of 7 days (∼100 µg mL−1). For the first time, FT receptors (FOLR‐1 and FOLR‐3) are discovered and also overexpressed on activated human gingival fibroblasts, representing a favorable target in the oral environment. Although FT itself does not have antimicrobial effects, the nanomechanical properties of biofilm are changed after topical FT administration. In vivo systemic toxicity of PCL‐MIP@FT has been demonstrated to be a safe biomaterial (up to 1.3 mg kg−1). When the PCL‐MIP@FT is assessed in the subcutaneous tissue, it promoted an alleviating inflammation and may be able to stimulate tissue repair. The present findings have demonstrated the reliable in vitro and in vivo anti‐inflammatory actions of FT‐loaded polymer and support its use as a novel drug‐free therapeutic platform for modulating and mitigating inflammatory responses in dental implant‐related infections.
3D Nano‐Printed Bistable Microlens Actuator for Reconfigurable Micro‐Optical Systems
Authors: Calikoglu Aybuke , Lux Florian , Taege Yanis , Zappe Hans , Ataman Çağlar
Published: July 2024

The integration of multiple functional microscopy methods into a single, miniaturized instrument, known as multimodal endomicroscopy, presents significant challenges due to the often conflicting optical requirements of each imaging modality. In this study, the use of 3D nano‐printing based on two‐photon polymerization for the monolithic manufacturing of complete optical MEMS devices is investigated as an enabling platform for multimodal endoscopy. This approach offers unparalleled miniaturization, design flexibility, and alignment precision of micro‐optics and actuators. In particular, the design, fabrication, and characterization of a monolithically 3D nano‐printed bistable microlens actuator are discussed. Bistability allows the microlens to switch between two stable positions, thereby changing the focus distance and numerical aperture. The actuator features two coils with opposing current directions, which create a magnetic field gradient around a polymer micro‐magnet. This configuration allows for robust switching between stable positions with an average axial distance of 168.3 ± 7.3 µm. Experiments conducted to ascertain the optical characterization of the actuator demonstrate its capacity to transition between different optical modes. The beam widths are measured to be in the range of 4.1 ± 0.2 µm in the high‐resolution mode and 11.3 ± 1.1 µm in the extended depth of focus mode.
Self‐Nanoformulating Poly(2‐oxazoline) and Poly(2‐oxazine) Copolymers Based Amorphous Solid Dispersions as Microneedle Patch: A Formulation Study
Authors: D'Amico Carmine , Ziegler Anna‐Lena , Kemell Marianna , Molinaro Giuseppina , Luxenhofer Robert , Santos Hélder A.
Published: July 2024

A pioneering approach in the domain of transdermal drug delivery systems (TDDS) is introduced by using microneedles (MNs) fabricated from an amorphous solid dispersion comprising only a model drug and an amphiphilic block copolymer to form a drug nanoformulation upon MN dissolution. To maximize drug loading and ensure consistent release, a minimalist formulation that achieves 40 wt% drug loading, which is a significant improvement over existing methods, is developed. Using scanning electron microscopy, the morphology of MNs is examined across a spectrum of drug loading ratios, demonstrating the consistency in structure and integrity. Mechanical testing confirms the MNs' proficiency in effective skin penetration. A comparative study on the formation of polymeric micelles underscores the innovative concept of a “nano‐in‐micro drug delivery system”. The results demonstrate that MNs manufactured from an amorphous solid dispersion of drug and amphiphilic block copolymer with ultra‐high loading enhance the availability and release dynamics of hydrophobic drugs, positioning them as a tool for enhancing TDDS. This study sets a new benchmark in the utilization of polymer‐drug nanoformulations for transdermal applications and underscores the capacity for high drug loading and the creation of adaptable drug delivery mechanisms for the studied amphiphilic block copolymer.
Oxidative Photochemical Cyclisations to Access Spiroketals
Authors: Trevorrow Jonathan , Sibanda Nhlanhla , O'Kearney‐McMullan Anne , Miller Potucka Lucie , Dobbs Adrian P.
Published: July 2024

The spiroketal moiety is an important substructure within many biological natural products. One method to access them is via the oxidative cyclisation of a pendant hydroxyl group on to a pre‐formed pyran. However applications of this methodology have been severely limited by requiring the use of toxic oxidants, such as lead (IV) tetraacetate or mercuric oxide. Herein we report a high yielding photochemical route to prepare complex spiroketals using an oxidative photochemical approach employing iodine monochloride and sodium acetate and demonstrate the methodology to the synthesis of a number of insect pheromones.
Benzene‐1,3‐disulfonyl fluoride and Benzene‐1,3,5‐trisulfonyl fluoride: Low‐Cost, Stable, and Selective Reagents for SuFEx‐Driven Deoxyazidation
Authors: Vishwakarma Dharmendra S. , Moses John E.
Published: July 2024

The development of synthetic methods for the synthesis of organic azides is highly important, given their critical role in advancing click chemistry over the last twenty years. We report a reagent‐economical, reliable, and scalable synthesis of alkyl azides from primary and secondary alcohols. This robust click method capitalizes on the synergistic interaction between Sulfur Fluoride Exchange (SuFEx) reagents – specifically, benzene‐1,3‐disulfonyl fluoride (BDSF) or benzene‐1,3,5‐trisulfonyl fluoride (BTSF) – and trimethylsilyl azide (TMSN3). The method offers procedural ease, accommodates a wide array of substrates, and enables late‐stage functionalization. Additionally, we demonstrate the protocol‘s adaptability by validating a straightforward one‐pot deoxyazidation‐CuAAC sequence for drug discovery applications.
Biomimetic Supramolecular Assembly with IGF‐1C Delivery Ameliorates Inflammatory Bowel Disease (IBD) by Restoring Intestinal Barrier Integrity
Authors: Fu Enze , Qian Meng , He Ningning , Yin Yilun , Liu Yue , Han Zhibo , Han ZhongChao , Zhao Qiang , Cao Xiaocang , Li Zongjin
Published: July 2024

The management of dysfunctional intestinal epithelium by promoting mucosal healing and modulating the gut microbiota represents a novel therapeutic strategy for inflammatory bowel disease (IBD). As a convenient and well‐tolerated method of drug delivery, intrarectal administration may represent a viable alternative to oral administration for the treatment of IBD. Here, a biomimetic supramolecular assembly of hyaluronic acid (HA) and β‐cyclodextrin (HA‐β‐CD) for the delivery of the C domain peptide of insulin‐like growth factor‐1 (IGF‐1C), which gradually releases IGF‐1C, is developed. It is identified that the supramolecular assembly of HA‐β‐CD enhances the stability and prolongs the release of IGF‐1C. Furthermore, this biomimetic supramolecular assembly potently inhibits the inflammatory response, thereby restoring intestinal barrier integrity. Following HA‐β‐CD‐IGF‐1C administration, 16S rDNA sequencing reveals a significant increase in the abundance of the probiotic Akkermansia, suggesting enhanced intestinal microbiome homeostasis. In conclusion, the findings demonstrate the promise of the HA‐based mimicking peptide delivery platform as a therapeutic approach for IBD. This biomimetic supramolecular assembly effectively ameliorates intestinal barrier function and intestinal microbiome homeostasis, suggesting its potential for treating IBD.
High‐Performance Sensing Platform Based on Morphology/Lattice Collaborative Control of Femtosecond‐Laser‐Induced MXene‐Composited Graphene
Authors: Su Ruige , Liang Misheng , Yuan Yongjiu , Huang Chaojun , Xing Wenqiang , Bian Xiaomeng , Lian Yiling , Wang Bo , You Zheng , You Rui
Published: July 2024

Flexible sensors based on laser‐induced graphene (LIG) are widely used in wearable personal devices, with the morphology and lattice arrangement of LIG the key factors affecting their performance in various applications. In this study, femtosecond‐laser‐induced MXene‐composited graphene (LIMG) is used to improve the electrical conductivity of graphene by incorporating MXene, a 2D material with a high concentration of free electrons, into the LIG structure. By combining pump‐probe detection, laser‐induced breakdown spectroscopy (LIBS), and density functional theory (DFT) calculations, the morphogenesis and lattice structuring principles of LIMG is explored, with the results indicating that MXene materials are successfully embedded in the graphene lattice, altering both their morphology and electrical properties. The structural sparsity and electrical conductivity of LIMG composites (up to 3187 S m−1) are significantly enhanced compared to those of LIG. Based on these findings, LIMG has been used in wearable electronics. LIMG electrodes are used to detect uric acid, with a minimum detection limit of 2.48 µM. Additionally, LIMG‐based pressure and bending sensors have been successfully used to monitor human limb movement and pulse. The direct in situ femtosecond laser patterning synthesis of LIMG has significant implications for developing flexible wearable electronic sensors.
Integrated Mixed Potential Gas Sensor with Efficient Structure for Discriminative Volatile Organic Compounds Detection
Authors: Lv Siyuan , Gu Tianyi , Pu Qi , Wang Bin , Jia Xiaoteng , Sun Peng , Wang Lijun , Liu Fangmeng , Lu Geyu
Published: July 2024

Amid growing interest in the precise detection of volatile organic compounds (VOCs) in industrial field, the demand for highly effective gas sensors is at an all‐time high. However, traditional sensors with their classic single‐output signal, bulky and complex integrated structure when forming array often involve complicated technology and high cost, limiting their widespread adoption. Here, this study introduces a novel approach, employing an integrated YSZ‐based (YSZ: yttria‐stabilized zirconia) mixed potential sensor equipped with a triple‐sensing electrode array, to efficiently detect and differentiate six types of VOCs gases. This innovative sensor integrates NiSb2O6, CuSb2O6, and MgSb2O6 sensing electrodes (SEs), which are sensitive to pentane, isoprene, n‐propanol, acetone, acetic acid, and formaldehyde gases. Through feature engineering based on intuitive spike‐based response values, it accentuates the distinct characteristics of every gas. Eventually, an average classification accuracy of 98.8% and an overall R‐squared error (R2) of 99.3% for concentration regression toward six target gases can be achieved, showcasing the potential to quantitatively distinguish between industrial hazardous VOCs gases.
Nitrogen‐Doped TiO2−x(B)/MXene Heterostructures for Expediting Sulfur Redox Kinetics and Suppressing Lithium Dendrites
Authors: Zhen Mengmeng , Wang Xiaoyu , Yang Qihang , Zhang Zihang , Hu Zhenzhong , Li Zhenyu , Wang Zhongchang
Published: July 2024

Practical application of lithium–sulfur (Li–S) batteries is severely impeded by the random shuttling of soluble lithium polysulfides (LiPSs), sluggish sulfur redox kinetics, and uncontrollable growth of lithium dendrites, particularly under high sulfur loading and lean electrolyte conditions. Here, nitrogen‐doped bronze‐phase TiO2(B) nanosheets with oxygen vacancies (OVs) grown in situ on MXenes layers (N‐TiO2−x(B)‐MXenes) as multifunctional interlayers are designed. The N‐TiO2−x(B)‐MXenes show reduced bandgap of 1.10 eV and high LiPSs adsorption‐conversion‐nucleation‐decomposition efficiency, leading to remarkably enhanced sulfur redox kinetics. Moreover, they also have lithiophilic nature that can effectively suppress dendrites growth. The cell based on the N‐TiO2−x(B)‐MXenes interlayer under sulfur loading of 2.5 mg cm−2 delivers superior cycling performance with a high specific capacity of 690.7 mAh g−1 over 600 cycles at 1.0 C. It still has a notable areal capacity of 6.15 mAh cm−2 after 50 cycles even under a high sulfur loading of 7.2 mg cm−2 and a low electrolyte‐to‐sulfur (E/S) ratio of 6.4 µL mg−1. The Li‐symmetrical battery with the N‐TiO2−x(B)‐MXenes interlayer showcases a low over‐potential fluctuation with 21.0 mV throughout continuous lithium plating/stripping for 1000 h. This work offers valuable insights into the manipulation of defects and heterostructures to achieve high‐energy Li–S batteries.
Revisiting the Electrocatalyst Role on Lignin Depolymerization
Authors: Lindenbeck Lucie M. , Barra Vanessa C. , Beele Björn B. , Rodrigues Bruno V. M. , Slabon Adam
Published: July 2024

Replacing fossil resources as the primary source of carbon‐based chemicals by alternative feedstocks, while implementing more sustainable production routes, has become imperative for environmental and resource sustainability. In this context, lignin, often treated as a biomass waste, emerges as an appealing candidate, considering the principles of circular economy. For this pursuit, depolymerization methods offer potential strategies to harness lignin to produce valuable organic chemicals, while electrocatalysis processes stand out especially in the context of sustainability, as they can be powered by electricity from renewable sources. This minireview article explores the pivotal role of various electrocatalysts in lignin depolymerization, investigating both oxidative and reductive pathways. Emphasizing recent advancements, the review delves into the diverse nature of electrocatalysts and their influence on lignin valorization. Highlighting current trends, the discussion encompasses the catalytic mechanisms and selectivity of electrochemical processes employed for lignin breakdown. Additionally, some insights into emerging technologies are also offered, emphasizing the need for sustainable and efficient strategies. By providing an overview of the field, this minireview aims to guide future research endeavors toward innovative electrocatalytic approaches for lignin depolymerization, paving the way for sustainable biorefinery processes.
Issues of Sampling and Representativeness in Large‐Scale LiDAR‐Derived Archaeological Surveys in Mediterranean Contexts
Authors: Fontana Giacomo
Published: July 2024

Landscape‐scale LiDAR‐based studies are becoming increasingly prevalent in archaeology, mainly focusing on detecting archaeological sites to create datasets for spatial analysis. However, the representativeness of these datasets in accurately reflecting the surviving distributions of archaeological sites has often been overlooked. This paper discusses issues of sampling and representativeness in LiDAR‐derived datasets, particularly within the scope of large‐scale landscape studies in Mediterranean contexts. Drawing insights from the Ancient Hillforts Survey, which analysed 15 296 km2 in south‐central Italy, the study examines the variability in the visibility of different site typologies in open‐source but low‐resolution LiDAR data. Through an examination of hillforts, platform farms, settlements, field systems, traces of Roman centuriation, and transhumance routes, the paper highlights significant variability in the identification and mapping within and across different site types. Recognizing the need to account for this variability in the development of spatial analysis, the paper discusses the use of sampling areas to address this variability. This approach aims to effectively mitigate potential biases in analysis, emphasizing the necessity for nuanced methodologies in interpreting LiDAR data for archaeological research.
Unveiling Anti‐Malarial, Antimicrobial, Antioxidant Efficiency and Molecular Docking Study of Synthesized Transition Metal Complexes Derived From Heterocyclic Schiff Base Ligands
Authors: Rani Manju , Devi Jai , Kumar Binesh , Rathi Manisha
Published: July 2024

Malaria, a persistent and ancient adversary, continues to impact vast regions worldwide, afflicting millions and severely affecting human health and well‐being. Recently, despite significant progress in combating this parasitic disease, malaria remains a major global health concern, especially in areas with limited resources and vulnerable populations. Consequently, identifying and developing effective agents to combat malaria and its associated dysfunctions is essential therefore the two new Schiff base ligands incorporated Co(II), Ni(II), Cu(II) and Zn(II) ions were synthesized and thoroughly characterized. The synthesized compounds were assessed for in vitro anti‐malarial and antimicrobial efficacy, compounds (9, 10) demonstrated highest potential with IC50=1.08±0.09 to 1.18±0.04 μM against P. falciparum and MIC=0.0058 μmol/mL against C. albicans and E. coli, respectively. The complexes (5, 6) were effectively reduce mitigate oxidative stress with lowest IC50 value of 2.69±0.12 to 2.87±0.09 μM. Moreover, the biological findings were reinforced by a molecular docking investigation involving the potential compounds (2, 7–10) against dihydroorotate dehydrogenase and sterol 14‐alpha demethylase proteins which exposed complex's excellent biological response than their parent ligands. ADMET profiling was used to confirm the compounds’ oral drug‐like features. This research offers promising prospects for future multi‐functional drug innovations targeting malaria, pathogenic infections, and oxidative stress.
Human papillomavirus‐16 E6‐positive cervical cancer attenuated by potent 2‐(4‐biphenylyl)‐N‐(1‐ethyl‐4‐piperidinyl) acetamide second‐generation analogs with improved binding affinity
Authors: Kumar Ashish
Published: July 2024

Human papillomavirus (HPV) infection, particularly HPV16, is a major contributor to the development of cervical cancer. Given the urgent need for novel therapeutic strategies targeting HPV‐associated cancers, this study focuses on characterizing second‐generation analogs of a lead compound, as a potential inhibitor of HPV16‐E6. Protein–ligand docking, Gibbs binding free energy estimation, and molecular dynamics simulations were conducted. HPV16‐infected SiHa and CaSki cell lines were used. MTT (3‐(4,5‐dimethylthiazolyl‐2)‐2,5‐diphenyltetrazolium bromide) assay for proliferation and flow cytometry for target inhibition and apoptosis were employed. Computational and cell proliferation analyses revealed that modifications to E6‐855, particularly in the piperidinyl group, enhanced binding affinities against HPV16‐E6, with E6‐272 demonstrating superior binding properties. Molecular dynamics simulations confirmed the stable binding of E6‐272 to HPV16‐E6, supported by favorable binding energy estimates. E6‐272 inhibited the proliferation of SiHa and CaSki cells with GI50 values of 32.56 and 62.09 nM, respectively. The compound reduced HPV16‐E6‐positive population, while inducing the early and late phase apoptosis in these cells. Structural alterations at the piperidinyl group of E6‐855 identified E6‐272 as a promising inhibitor of HPV16‐E6 with improved efficacy against HPV16‐E6. Further experimental validation of E6‐272 and its analogs warrant to advance its clinical utility in combating HPV‐associated cancers.
All Colloidal Supercapattery: Colloid@carbon Cloth Electrodes Meet “Water‐in‐Salt” Electrolyte
Authors: Sun Xiangfei , Chen Kunfeng , Xue Dongfeng
Published: July 2024

The pursuit of excellent electrochemical performance, nonflammability and environmental friendliness of aqueous batteries and supercapacitors has driven efforts to find high‐energy yet reliable electrode materials and electrolyte solutions. Here, all colloidal supercapattery are developed using high‐concentration “water‐in‐salt” electrolytes (LiTFSI‐KOH) and pseudocapacitive colloid@carbon cloth as both positive and negative electrodes, which showed merits of batteries and supercapacitors. Ni/Co‐colloid @carbon cloth positive and Fe‐colloid @carbon cloth negative electrodes can be synthesized by in situ electrochemical reaction. The maximum operating voltage of an aqueous colloidal supercapattery is 1.8 V, and the energy density can reach 73.98 Wh kg−1 at a power density of 1799.5 W kg−1. The specific capacitance of the aqueous colloidal supercapattery still maintains 74.3 % of the initial after 2000 cycles of charge/discharge measurement. The combination of quasi ion colloidal materials and “water‐in‐salt” electrolyte pave a profound way to achieve high energy and power ability simultaneously at the supercapattery device.
Prussian Blue Analogues Derived Bimetallic CoNi@NC as Efficient Oxygen Reduction Reaction Catalyst for Mg‐Air Batteries
Authors: Dong Xiaoyang , Wang Jinxing , Ling Junqian , Zhang Ying , Xu Junyao , Zeng Wen , Huang Guangsheng , Wang Jingfeng , Pan Fusheng
Published: July 2024

The magnesium‐air (Mg‐air) batteries are regarded as a highly promising system for electrochemical energy conversion and storage, owing to their exceptional energy density, notable safety and eco‐friendliness. The development of high‐performance and durable non‐noble metal catalysts for the cathodic oxygen reduction reaction (ORR) is crucial for advancing the practical use of Mg‐air batteries. The synergistic interaction between different metals in bimetallic catalysts is an effective strategy for enhancing the activity and stability of the catalysts. Herein, various prussian blue analogues (PBA) were selected as precursors to synthesis the bimetallic CoNi@NC, monometallic Co@NC and Ni@NC catalysts due to tunable chemical compositions. Compared with Co@NC and Ni@NC, the bimetallic CoNi@NC pyrolyzed at 600 °C (CoNi@NC‐600) exhibits outstanding ORR performances and stability in alkaline (0.1 M KOH) and neutral (3.5 wt % NaCl) electrolytes. Following 5000 CV cycles, the half‐wave potentials for CoNi@NC‐600 show only minor negative shifts of 8 and 7 mV, respectively. Meanwhile, the CoNi@NC‐600 possesses the similar ORR reaction mechanism and activity with Pt/C. The primary Mg‐air battery assembled with CoNi@NC‐600 displays better discharge performances than that of Co@NC and Ni@NC. This study lays the foundation for future investigations into the advancement of non‐precious bimetallic catalysts for ORR in Mg‐air batteries.
The Zero Effect: An Eye‐Tracking Study of Affect and Motivation in Risky Choices
Authors: Ludwig Jonas , Jaudas Alexander , Achtziger Anja
Published: July 2024

Decision makers often prefer safe wins over risky gambles, even if the latter promise higher payoffs than the former. One mechanism that explains this choice pattern is the certainty effect, whereby probabilities of 0 and 1 are interpreted accurately but intermediate probabilities are distorted by diminishing sensitivity. We tested an alternative explanation that was recently proposed, the idea that people would be motivated by avoiding zero outcomes rather than being attracted to sure gains. This zero‐outcome aversion in gain‐domain choices was called the zero effect. By analogy, we proposed that decision makers would approach zero outcomes in the loss domain. Two eye‐tracking experiments investigated visual attention as a key component of the zero effect in the gain domain (Experiment 1) and the loss domain (Experiment 2). Choices were consistent with the zero effect. In the gain domain, gambles were chosen less frequently if they included a zero outcome. In contrast, zero‐outcome gambles were chosen more frequently in the loss domain. Eye movements and pupillometry indicated that zero outcomes in both domains (a) were less frequently fixated than other outcomes and (b) were associated with increased arousal. We concluded that domain‐specific affective responses to zero outcomes aligned with approach/avoidance motivation. These distinct motivations in turn biased information search and choice behavior.
Exploring the efficacy of ecolabels as a marketing strategy: Insights from the emerging bioplastic packaging market
Authors: Baskoro Muhammad Lahandi , Tjahjono Benny , Beltran Macarena , Bogush Anna , Brahmana Rayenda Khresna
Published: July 2024

The packaging industry's significant role in plastic production and environmental pollution underscores the need for more sustainable alternatives. Bioplastics emerge as a promising solution, yet consumer understanding of this innovative material often lags, particularly in emerging markets. This study thus aims to explore effective marketing strategies for communicating bioplastic packaging to shape consumer adoption and disposal practices in such markets. Through a case study approach, we examine the role of ecolabels as a marketing tool across key sectors of the bioplastic packaging supply chain. Drawing upon the signalling theory, we identify key characteristics of effective signals, including costly signalling, visibility, clarity, fitness, consistency and credibility, which should be integrated into a broader context of ecolabels design in order to encourage consumer adoption and responsible disposal. Our study also identifies instances where noises from the environment may have little impact and where communication gaps hinder feedback loops between consumers and producers.
How platformisation transforms the psychological profession: Reflections from a proposal of indicators for the classification of psychological platforms
Authors: Gambirasio Maddalena , Ivaldi Silvia , Scaratti Giuseppe
Published: July 2024

This article is part of a research context that examines the impact of new technologies on psychological practice. We argue that the use of technological mediators in the execution of the psychological profession goes beyond mere modifications to methods and tools, transforming the very nature of the discipline and influencing the associated professional identity. Specifically, our focus is on ‘psychological platforms’ as emerging work contexts that represent a relatively recent but rapidly growing phenomenon. Beginning with what is present in the literature on the subject of platform classification, this research project is intended to create functional and useful indicators for an analysis of psychological platforms. Based on these indicators, it is possible to reflect on the impact that the various characteristics of psychological platforms have on the psychological profession and psychological professionals themselves. In doing so, we seek to address the following research questions: (a) What are the main characteristics of psychological platforms, (b) which dimensions of the psychological profession are influenced by the use of a given platform in conducting psychological interventions and (c) how does the platformisation of the psychological profession affect the role of the psychologist? Our analysis is based on an in‐depth literature review regarding the platforms, followed by a desk analysis of 44 psychological platforms operating in the Italian context. By adopting this perspective, this article illuminates the dynamics shaping psychological practice in the digital era and suggests guidelines for future research in this continually evolving field.
Effects of plasma‐activated water and mild heating on Escherichia coli inactivation during wheat tempering and flour quality
Authors: Rivera Jared , Wang Qingyang , Doddabematti Prakash Shivaprasad , Salvi Deepti , Siliveru Kaliramesh
Published: July 2024

Background and Objectives

Heat treatment, as a pathogen reduction step, could compromise flour quality. Plasma‐activated water (PAW) is a novel pathogen reduction treatment for foods. Combining these treatments could improve pathogen inactivation during wheat tempering and maintain flour quality. This study evaluated the effects of PAW and mild heating on Escherichia coli inactivation during wheat tempering and wheat flour quality.

Findings

E. coli was inoculated into wheat grains at 6.0 ± 0.1 log CFU/g. A 5‐log reduction was achieved after 6 h of tempering with PAW and heating (55°C), whereas 12 h were needed when using heating and deionized water (DI). Tempering with DI (control) and PAW alone only produced a 1‐log reduction after 24 h. The PAW and PAW + heat tempering treatments produced flours with comparable yield, physicochemical, dough rheology, and bread characteristics compared to the control treatment.

Conclusion

Mild heating and PAW tempering demonstrated a synergistic effect as it produced greater E. coli reductions at shorter tempering times compared to the individual treatments. The hurdle approach used in this study did not compromise flour quality.

Significance and Novelty

The demonstrated hurdle approach can be a viable pathogen mitigation step in wheat milling which could help improve food safety of wheat‐based foods.
N‐Glycosylation‐Induced Pathologic Protein Conformations as a Tool to Guide the Selection of Biologically Active Small Molecules
Authors: Magni Andrea , Sciva Cristiano , Castelli Matteo , Digwal Chander S. , Rodina Anna , Sharma Sahil , Ochiana Stefan , Patel Hardik J. , Shah Smit , Chiosis Gabriela , Moroni Elisabetta , Colombo Giorgio
Published: July 2024

Post‐translational modifications such as protein N‐glycosylation, significantly influence cellular processes. Dysregulated N‐glycosylation, exemplified in Grp94, a member of the Hsp90 family, leads to structural changes and the formation of epichaperomes, contributing to pathologies. Targeting N‐glycosylation‐induced conformations offers opportunities for developing selective chemical tools and drugs for these pathologic forms of chaperones. We here demonstrate how a specific Grp94 conformation induced by N‐glycosylation, identified previously via molecular dynamics simulations, rationalizes the distinct behavior of similar ligands. Integrating dynamic ligand unbinding information with SAR development, we differentiate ligands productively engaging the pathologic Grp94 conformers from those that are not. Additionally, analyzing binding site stereoelectronic properties and QSAR models using cytotoxicity data unveils relationships between chemical, conformational properties, and biological activities. These findings facilitate the design of ligands targeting specific Grp94 conformations induced by abnormal glycosylation, selectively disrupting pathogenic protein networks while sparing normal mechanisms.
Halogen and Chalcogen Activation by Nucleophilic Catalysis
Authors: Mondal Haripriyo
Published: July 2024

The high utility of halogenated organic compounds has prompted the development of numerous transformations that install the carbon‐halogen motif. Halogen functionalities, deemed as “functional and functionalizable” molecules due to their capacity to modulate diverse internal properties, constitute a pivotal strategy in drug discovery and development. Traditional routes to these building blocks have commonly involved multiple steps, harsh reaction conditions, and the use of stoichiometric and/or toxic reagents. With the emergence of solid halogen carriers such as N‐halosuccinimides, and halohydantoins as popular sources of halonium ions, the past decade has witnessed enormous growth in the development of new catalytic strategies for halofunctionalization. This review aims to provide a nuanced perspective on nucleophilic activators and their roles in halogen activation. It will highlight critical discoveries in effecting racemic and asymmetric variants of these reactions, driven by the development of new catalysts, activation modes, and improved understanding of chemical reactivity and reaction kinetics.
Integration of a Hydrogen Storage Cavern into the Carbon2Chem® Project
Authors: Schlichtenmayer Maurice , Rockenschaub Monika , Wagler Torsten , Schneiders Dan , Presse Ralf
Published: July 2024

Underground salt caverns allow large hydrogen storage capacities at low specific costs. Such storage is required to balance fluctuating hydrogen supply and constant demand of large consumers as a methanol plant from the Carbon2Chem® project. The geological and technical feasibility for developing up to 168 Mio. m3 (n.c.) or 595 GWh of working gas capacity until 2040 at a location in the Lower Rhine Bay is described. Various options for realization as well as a novel process for cavern leaching parallel to hydrogen storage operation are evaluated. Further work is required including geological exploration and optimization of brine production. The main hurdles for investment decisions are the political uncertainties on the hydrogen storage market design and on the ramp‐up of the hydrogen market.
Effect of superimposing oscillatory flow in a milli‐channel with static internals—A numerical study
Authors: Manthani Navya , Nanavath Vijaya Lakshmi , Vedantam Sreepriya
Published: July 2024

Superimposition of oscillatory flow over the axial flow is expected to further enhance the mixing phenomenon based on the limited reported literature. A detailed study on the physics of such superimposed flows will be useful to widen the scope of application of static mixers with superimposed oscillatory flow in continuous modes of operation for several purposes. The flow behaviour of a water–vinyl acetate system in a milli‐channel with static internals is studied under the laminar flow regime using computational fluid dynamics (CFD) as a tool. A CFD model is developed and validated with reported literature on a Kenics static mixer. The effect of oscillatory flow superimposed over the axial flow in a milli‐channel is studied for Ren = 5 and Reo = 20–65. Residence time distribution (RTD) studies have been carried out and compared numerically for two different geometries, (1) tube without an internal and (2) tube with internals, for two different velocities, (1) net axial velocity and (2) superimposed oscillatory velocity. Results of these RTD studies indicate a sharp distribution in the channel with static internals having superimposed oscillatory flow followed by the channel with static internals with net axial velocity and then a tube without an internal. It is also found that Péclet number (Pe) for static internals with oscillatory flow > net axial flow > tube without an internal (736 > 641 > 315). Further, velocity magnitude, pressure, and Q‐criterion are discussed in detail to understand fluid flow behaviour in the milli‐channel. From this research, it is understood that superimposing oscillatory flow along with static internals resulted in enhanced mixing when compared with a tube with no internal.
Association ofRANandRANBP2Gene Polymorphisms With Glioma Susceptibility in Chinese Children
Authors: Lin Qianru , Chen Wei , Tan Jiating , Qian Sifan , Su Huarong , Zhao Liang , Yuan Li , Ruan Jichen , Huang Xiaokai , Zhou Haixia
Published: July 2024

Background

Glioma is the most prevalent pediatric central nervous system malignancy. RAN, member RAS oncogene family (RAN), is a key signaling molecule that regulates the polymerization of microtubules during mitosis. RAN binding protein 2 (RANBP2) is involved in DNA replication, mitosis, metabolism, and tumorigenesis. The effects ofRANandRANBP2gene polymorphisms on glioma susceptibility in Chinese children are currently unknown.

Aims

This study aimed to evaluate the association betweenRANandRANBP2gene polymorphisms and glioma susceptibility in Chinese children.

Methods and Results

We recruited 191 patients with glioma and 248 children without cancer for this case–control study. Polymerase chain reaction‐based TaqMan was applied to gene sequencing and typing. Logistic regression model‐calculated odds ratio and 95% confidence interval were used to verify whether the gene polymorphisms (RANrs56109543 C>T, rs7132224 A>G, rs14035 C>T, andRANBP2rs2462788 C>T) influence glioma susceptibility. Based on age, gender, tumor subtype, and clinical stage, stratified analyses of risk and protective genotypes were conducted.pvalues for mutant genotype analyses were all >0.05, indicating no significant correlation between these gene polymorphisms and glioma risk.

Conclusion

RANandRANBP2gene polymorphisms were not found to be statistically significantly associated with glioma susceptibility in Chinese children. Other potential functional gene polymorphism loci ofRANandRANBP2will need to be evaluated in the search for novel glioma biomarkers.
Association of Peri‐Implant Mucosa Dimensions With Emergence Profile Angles of the Implant Prosthesis
Authors: Rungtanakiat Piboon , Thitaphanich Natchaya , Janda Martin , Strauss Franz Josef , Arksornnukit Mansuang , Mattheos Nikos
Published: July 2024

Objectives

The primary aim of this cross‐sectional study was to investigate the association between prosthesis design and peri‐implant mucosa dimensions and morphology. The secondary aim was to investigate associations between mucosal dimensions and the presence of mucositis.

Materials and Methods

Forty‐seven patients with 103 posterior bone level implants underwent clinical and radiographic examination, including cone beam computer tomography and intraoral optical scanning. Three‐dimensional models for each implant and peri‐implant mucosa were constructed. Vertical mucosa height (TH), horizontal mucosa width at implant platform (TW), and 1.5 mm coronal of the platform (TW1.5), as well as mucosal emergence angle (MEA), deep angle (DA), and total contour angle (TA) were measured at six sites for each implant.

Results

There was a consistent correlation between peri‐implant mucosa width and height (β = 0.217, p < 0.001), with the width consistently surpassing height by a factor of 1.4–2.1. All three angles (MEA, DA, TA) were negatively associated with mucosa height (p < 0.001), while DA was negatively associated with mucosa width (TW1.5) (p < 0.001, β = −0.02, 95% CI: −0.03, −0.01). There was a significant negative association between bleeding on probing (BoP) and mucosa width at platform (OR 0.903, 95% CI: 0.818–0.997, p = 0.043) and 1.5 coronal (OR 0.877, 95% CI: 0.778–0.989, p = 0.033). Implants with less than half sites positive for BoP (0–2/6) had significantly higher mucosa height (OR 3.51, 95% CI: 1.72–7.14, p = 0.001).

Conclusions

Prosthesis design can influence the dimensions of the peri‐implant mucosa, with wider emergence profile angles associated with reduced peri‐implant mucosa height. In particular, a wider deep angle is associated with reduced mucosa width in posterior sites. Reduced peri‐implant mucosa height and width are associated with more signs of inflammation.

Trial Registration

Registered in Thai Clinical Trials Registry: http://www.thaiclinicaltrials.org/show/TCTR20220204002.
Favored Amorphous LixSi Process with Restrained Volume Change Enabling Long Cycling Quasi‐Solid‐State SiOx anode
Authors: Wang Ruoyang , Wu Yuqing , Niu Yifan , Yang Qing , Li Haoyu , Chen Ting , Song Yang , Zhong Benhe , Wu Zhenguo
Published: July 2024

Silicon‐based anodes are becoming promising materials due to their high specific capacity. However, the intrinsically large volume change brought about by the alloying reaction results in the crushing of the active particles and destruction of the electrode structure, which severely limits its practical application. Various structured and modified silica‐based anodes exhibit improved cycling stability and the demonstrated ability to mitigate their volume changes through interfacial and binder strategies. However, the issue of large volume changes in silicon‐based anodes remains. Herein, we report a gel polymer electrolyte (GPE) prepared through an in situ thermal polymerization process that is suitable for SiOx anode materials and achieving long‐term cycling stability. GPE‐based cells essentially mitigate the volume change of SiOx anodes by guiding the unique lithiation/delithiation mechanism that tends to favor the formation and delithiation of amorphous‐LixSi (a‐LixSi) with smaller volume change, thereby mitigating electrode damage and cracking, and achieving the significant improvement in cycling performance. The prepared GPE‐SiOx cells retained 693.80 mAh g−1 reversible capacity after 450 cycles at 500 mA g−1. In addition, the prelithiation process was incorporated to mitigate capacity fluctuations and improve the Initial Coulombic Efficiency (ICE), and a reversible capacity of 641.90 mAh g−1 was retained after 480 cycles.
Multi‐band pass negative group delay circuit with low insertion loss
Authors: Chang Niannan , Yuan Aixia , Wang Ying , Liu Junzheng
Published: July 2024

A novel multi‐band pass negative group delay circuit has been designed and proposed. The circuit consists of three types of components: capacitance, inductance, and resistance. An n‐order bandpass negative group delay circuit was analyzed and presented, and taking a three‐frequency bandpass negative group delay circuit as an example, the influence of different component values on the circuit group delay and insertion loss was analyzed. The actual test results of this circuit are consistent with the simulation results, and it can achieve the function of a multi‐bandpass circuit. In actual testing, the circuit frequencies with negative group delay are 49, 82, and 102 MHz, with corresponding group delay values of −2.177, −2.058, and −1.903 ns and corresponding insertion loss values of −5.810, −5.835, and −5.866 dB.
LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53‐driven tumour progression through miR‐5683/FGF2
Authors: Liu Nannan , Jiang Xinxiu , Zhang Ge , Long Shuaiyu , Li Jiehan , Jiang Meimei , Jia Guiyun , Sun Renyuan , Zhang Lingling , Zhang Yingjie
Published: July 2024

N‐methyladenosine (m6A) represents a prevalent RNA modification observed in colorectal cancer. Despite its abundance, the biological implications of m6A methylation on the lncRNA CARMN remain elusive in colorectal cancer, especially for mutant p53 gain‐of‐function. Here, we elucidate that CARMN exhibits diminished expression levels in colorectal cancer patients with mutant p53, attributed to its rich m6A methylation, which promotes cancer proliferation, invasion and metastasis in vitro and in vivo. Further investigation illustrates that ALKBH5 acts as a direct demethylase of CARMN, targeting 477 methylation sites, thereby preserving CARMN expression. However, the interaction of mutant p53 with the ALKBH5 promoter impedes its transcription, enhancing m6A methylation levels on CARMN. Subsequently, YTHDF2/YTHDF3 recognise and degrade m6A‐modified CARMN. Concurrently, overexpressing CARMN significantly suppressed colorectal cancer progression in vitro and in vivo. Additionally, miR‐5683 was identified as a direct downstream target of lncRNA CARMN, exerting an antitumour effect by cooperatively downregulating FGF2 expression. Our findings revealed the regulator and functional mechanism of CARMN in colorectal cancer with mutant p53, potentially offering insights into demethylation‐based strategies for cancer diagnosis and therapy. The m6A methylation of CARMN that is prime for mutant p53 gain‐of‐function‐induced malignant progression of colorectal cancer, identifying a promising approach for cancer therapy.
Steroid lifting method during endoscopic submucosal dissection: A novel strategy for stricture prevention
Authors: Omae Masami , Maltzman Henrik , Vujasinovic Miroslav , Wang Naining , Baldaque‐Silva Francisco
Published: July 2024

A 73‐year‐old male patient was referred to us with a long Barrett's esophagus (BE). He had a history of pulmonary embolism under anticoagulant therapy. Esophagogastroduodenoscopy showed a C8M9 BE with no macroscopic lesions. Random biopsies from the BE revealed multifocal high‐grade dysplasia. The case was discussed in a multidisciplinary team conference and the decision for full resection of BE with endoscopic submucosal dissection (ESD) was made. Considering the large ESD resection and the high risk of stricture, we developed a novel preventive technique: the “steroid lifting method” for submucosal injection during ESD. Complete circumferential ESD with en bloc resection was performed using the “steroid lifting method”, without adverse events. Oral liquids were initiated on day 1 and the patient was discharged on day 4. Oral prednisolone (30 mg per day) was started and tapered for a total of 6 weeks. The pathological examination confirmed multifocal high‐grade dysplasia, with radical and curative resection. The patient had neither stricture, dysphagia nor recurrence of Barrett's mucosa at the 2, 6, 12, and 24‐month follow‐up. International guidelines recommend oral prednisolone and triamcinolone injection to prevent stricture formation in large ESD of esophageal squamous cell carcinoma. However, there is no solid data on BE ESD. The risk factors for stricture formation and the optimal preventive management after large BE ESD is not known. The “steroid lifting method” might be an option in this context. Large prospective studies addressing stricture formation and preventive measures on BE ESD are necessary.
Revisited Synthesis of Trispyrazolylborate Aluminum Halides Suban Kundu, Raju Chambenahalli, Alex P. Andrews and Ajay Venugopal*
Authors: Kundu Suban , Chambenahalli Raju , Andrews Alex P , Venugopal Ajay
Published: July 2024

Tris(3,5‐dimethylpyrazolyl)borate aluminum dihalides TpMe2AlX2 (X=Cl, Br and I) can be potential precursors for preparing highly electrophilic dications as well as low oxidation state aluminum compounds. However, the coordinative unsaturation in TpMe2AlX2 makes them susceptible to rearrangement to [Tp2Al][AlX4]. In this work, we revisited the synthesis of TpMe2AlX2 by isolating the solvent‐stabilized tris(3,5‐dimethylpyrazolyl)borate aluminum dihalides TpMe2AlX2(L) (X=Cl, Br; L = THF, HPMA). Efforts to isolate TpMe2All2 resulted in the ring opening of THF revealing the mediation of a highly reactive cationic aluminum species. The monocationic, [TpMe2AlCl(THF)2][B{C6H3(CF3)2}4] was prepared from TpMe2AlCl2(THF) via silver salt metathesis. Attempts to prepare the dicationic species [TpMe2Al(THF)3]2+ resulted in the instantaneous ring‐opening polymerization of THF.
Marginal inference for hierarchical generalized linear mixed models with patterned covariance matrices using the Laplace approximation
Authors: Ver Hoef Jay M. , Blagg Eryn , Dumelle Michael , Dixon Philip M. , Zimmerman Dale L. , Conn Paul B.
Published: July 2024

We develop hierarchical models and methods in a fully parametric approach to generalized linear mixed models for any patterned covariance matrix. The Laplace approximation is used to marginally estimate covariance parameters by integrating over all fixed and latent random effects. The Laplace approximation relies on Newton–Raphson updates, which also leads to predictions for the latent random effects. We develop methodology for complete marginal inference, from estimating covariance parameters and fixed effects to making predictions for unobserved data. The marginal likelihood is developed for six distributions that are often used for binary, count, and positive continuous data, and our framework is easily extended to other distributions. We compare our methods to fully Bayesian methods, automatic differentiation, and integrated nested Laplace approximations (INLA) for bias, mean‐squared (prediction) error, and interval coverage, and all methods yield very similar results. However, our methods are much faster than Bayesian methods, and more general than INLA. Examples with binary and proportional data, count data, and positive‐continuous data are used to illustrate all six distributions with a variety of patterned covariance structures that include spatial models (both geostatistical and areal models), time series models, and mixtures with typical random intercepts based on grouping.