bluuebunny/crossref_metadata_2025 huggingface dataset:
Media coverage as a moderator in the nexus between audit quality and ESG performance: Evidence from China
Authors: Cai Chun , Hazaea Saddam A. , Alsayegh Maha Faisal , Sahu Muskan , Raid Moodhi , Al‐ahdal Waleed M.
Published: October 2024

In response to growing pressure on companies to manage and improve their reputation regarding environmental, social, and governance (ESG) issues, the audit is regarded as a vital resource for ensuring ESG risk management, improving transparency, mitigating opportunistic constraints, and guaranteeing accurate reporting. The objective of this paper was to investigate the role of audit quality in improving ESG performance, as well as to examine the role of media coverage represented by ESG controversy score in moderating these relationships. We analyzed 303 Chinese companies with 2,121 observations covering the period from 2017 to 2023. The results suggest that the effects of audit quality as measured by the Big 4 and audit fee on improving ESG performance are positive but not significant. On the other hand, the results reveal that media coverage serves as a positive, albeit non-significant, moderating variable between audit quality measured by the Big 4 and ESG performance, while it has a significant negative effect when audit quality is evaluated based on audit fees. The results indicate that improving ESG performance is significantly linked to auditors intensifying their practices and implementing their work more stringently. More importantly, media coverage is an important additional driver and economic incentive that encourages companies to steer clear of poor ESG-related practices.
Peripapillary vessels density is closely related to cerebral white matter hyperintensities: An OCTA study
Authors: Song Yuanyue , Lai Zehua , Ding Kaiqi , Sun Yue , Zeng Lili
Published: October 2024

Background

Chronic cerebral hypoperfusion triggers the development of white matter hyperintensities (WMHs), common in cerebral small vessel disease (CSVD). However, conventional imaging techniques cannot visualize cerebral small vessels. The retina, a direct extension of the central nervous system, has an unclear correlation with WMHs. This study employs Optical coherence tomographic angiography (OCTA) to investigate vascular changes in the retina and explore its correlation with WMHs, aiming to provide a new method for assessing perfusion in early ischemic brain WMHs.

Methods

Forty-nine patients with WMHs were stratified into mild and moderate/severe WMHs groups based on MRI findings, utilizing the Fazekas and Scheltens scales. OCTA assessed fundus vessel microcirculation. Logistic regression analyzed the correlation between ocular fundus microcirculation and WMH severity and location. Additionally, ROC curves evaluated the diagnostic efficacy of each fundus vascular microcirculation index in determining WMH severity.

Results

After adjusting for multiple confounders, finding consistently indicated that the moderate/ severe WMHs group exhibited lower vessel density (VD) in the superior quadrant of the inner peripapillary region compared to the mild group [OR = 0.487, CI (0.255,0.929), p < 0.05]. ROC curves revealed that when combined with age, diabetes, and superior quadrant VD of the inner peripapillary region, specificity could be increased to 94.1%.

Conclusion

Peripapillary vessel density correlates closely with the severity of cerebral WMHs. Early morphological changes due to chronic hypoperfusion may initiate from the inner layer of the optic disc, and OCTA could offer a novel method for evaluating blood perfusion in ischemic WMHs.
Symmetrical choices and biased confidence during uncertain personality trait judgments
Authors: Weise Lorenz , Drüke Barbara , Gauggel Siegfried , Mainz Verena
Published: October 2024

While great methodological strides have been made in the area of decision making research, decisions that rely on subjective stimuli, such as personality traits, still pose a challenge for researchers, partly because it is difficult to define a standard of accuracy for such choices–they lack a “ground truth”. In studies on value-based decisions, this same problem has been circumvented by comparing uncertain subjective decisions against a separately assessed judgment of value–a “standard”. Here we apply this method in a task of verbal personality trait judgment, and show how a separately assessed standard judgment can be used to precisely control stimulus presentation and analyze subjective personality choices via the method of reverse correlation. Per trial, a series of quasi-randomly sampled adjectives was shown, which participants categorized as more descriptive of either themselves of another person well known to them. Participants also indicated their confidence in the response. Each trial’s difficulty was controlled based on the previously assessed standard judgment. Analysis of the behavioral data shows several decision-general properties during these personality judgments, such as symmetrical choices, steeper choice functions for confident trials, and a positive evidence bias during confidence judgment. We discuss how these findings can shed light on the cognitive processes involved in personality perception. The task and results together may help bridge the gap between research on complex, social forms of judgment and findings on more basic decision processes.
Fairness matters for change: A multilevel study on organizational change fairness, proactive motivation, and change-oriented OCB
Authors: Ling Bin , Yao Qu , Liu Yutong , Chen Dusheng
Published: October 2024

The success of organizational change often hinges on the perception of fairness within a change unit. This group-level organizational change fairness is crucial for enhancing proactive motivation states and fostering positive change-oriented organizational citizenship behavior (OCB). Rooted in the proactive motivation model, this study establishes a comprehensive multilevel framework to investigate the influence of group-level organizational change fairness on employees’ change-oriented OCB. It explores the mediating role of three proactive motivational states and the moderating impact of perceived change impact. Analyzing data collected from 597 employees within 107 teams across 43 Chinese companies, our findings indicate that group-level perceived organizational change fairness significantly predicts employees’ change-oriented OCB through organizational change self-efficacy, involvement, and positive emotional experiences. Furthermore, the study reveals that group-level perceived change impact moderates the relationship between group-level fairness perception and both change self-efficacy and positive emotional experiences, with stronger associations observed under conditions of low perceived change impact. These insights notably advance our understanding of the cross-level determinants influencing change-oriented OCB through perceived fairness and proactive motivation. Managers should focus on developing fairness perceptions to stimulate OCB by fostering employees’ proactive motivation states, particularly during low-impact organizational changes. Our findings provide valuable implications for organizational change management practices.
Validity and reliability of running gait measurement with the ViMove2 system
Authors: Mason Rachel , Barry Gillian , Hall Gary , Godfrey Alan , Stuart Samuel
Published: October 2024

Running biomechanics have traditionally been analysed in laboratory settings, but this may not reflect natural running gait. Wearable technology has the potential to enable precise monitoring of running gait beyond the laboratory. This study aimed to evaluate the analytical validity and intra-session reliability of temporal running gait outcomes measured by the ViMove2 wearable system in healthy adults. Seventy-four healthy adults (43 males, 31 females, aged 18–55 years) wore the inertial device, ViMove2 on the tibia. Participants ran on a treadmill for one minute at various speeds (8, 10, 12, 14km/hr), completed in a standardised shoe (Saucony Guide Runner). Running gait was measured with the ViMove2 wearable and 3D motion capture (Vicon). Temporal running gait outcomes included ground contact time (GCT) and cadence (steps/min). GCT and cadence from the ViMove2 had face validity with expected changes in outcome with different running speeds, but ViMove2 tended to over-estimate GCT, and under-estimate cadence compared to the reference, especially at slower speeds. GCT demonstrated moderate to good agreement to the reference at speeds >10km/hr, but poor agreement at 8km/hr and within female runners. Cadence had moderate to excellent agreement across speeds compared to the reference. GCT and cadence had excellent reliability across speeds, but at 8km/hr GCT had good agreement between trials. Overall, temporal gait outcomes of GCT and cadence can be measured with the ViMove2, but accuracy and reliability are impacted at slow running speeds and within female runners. Future work is needed to clarify sex or speed-dependent corrections to algorithms / outcomes to aid interpretation and application.
Determinants of fertility experience among reproductive women age (15–49) in Ethiopia: Application of count regression models
Authors: Yirsaw Bantie Getnet , Taye Birhan Ambachew , Seretew Wullo Sisay , Belete Aychew Kassa , Tesfie Tigabu Kidie
Published: October 2024

Introduction

Fertility refers to the average number of children born to a woman over her reproductive years. Due to cultural norms, economic development, education, access to healthcare, and government policies, fertility rates vary significantly across different countries and regions of the world. Ethiopia is one of the developing countries in Sub-Sahara Africa and its fertility rate has consistently been one of the highest in the world. Hence the main goal of this study was to identify the leading factors for the total number of children born per mother in Ethiopia.

Methods

This study used the most recent secondary data obtained from the 2019 Ethiopia Mini Demographic and Health Survey. A total weighted sample of 8885 women aged 15 to 49 was included in the study. The primary outcome variable in this study was the number of children born per mother, and different socio-demographic and economic factors that could influence fertility experience were included. The analysis was performed using STATA version 17 software. Negative Binomial regression model was used to assess the association between outcome and predictor variables. A p-value <0.05 was considered to be statistically significant.

Results

From a total of 8885 women, on average approximately 2.73 children were born per mother. Age of mothers (IRR = 1.08, 95% CI: (1.077, 1.082)), religion for Muslim (IRR = 1.13, 95% CI: (1.08, 1.18)) and others (IRR = 1.16, 95% CI: (1.11, 1.22)), level of education secondary and above (IRR = .61, 95% CI: (.58, .65)) and primary (IRR = .84, 95% CI: (.81, .87)), household member of six to nine (IRR = 1.24, 95% CI: (1.20, 1.28)) and household members more than nine people (IRR = 1.14, 95% CI: (1.07, 1.21)), wealth index for rich (IRR = .94, 95%, CI: (.91, .98)), marital status for not married (IRR = .49, 95%, CI: (.48, .51)), pregnant mothers (IRR = 1.08, 95%, CI: (1.02, 1.13)) and contraceptive users (IRR = 1.12, 95%, CI: (1.09, 1.16)) were the signficant variables for number of children ever born per mother.

Conclusion

In Ethiopia, the average number of children born per mother was approximately 2.73. Poisson and Negative Binomial regression models were compared, and we found the Negative Binomial regression model to be better to identify the determinants of fertility experience in Ethiopia. Age of mothers, religion, current pregnancy, use of contraceptive methods, mothers’ education level, household members, wealth index, number of children aged five and under, region (Somali, Gambela, and Addis Ababa), and marital status were the determinants responsible for fertility experience among mothers in Ethiopia. These findings are helpful for policymakers and healthcare professionals for developing targeted interventions and programs aimed at improving the high fertility rate experience in Ethiopia.
Effects of diluted seawater in drinking water on physiological responses, feeding, drinking patterns, and water balance in crossbred dairy goats
Authors: Nguyen Thiet , Truong Khang Van , Nguyen Khang Kim Thi , Nguyen Ngu Trong , Chaiyabutr Narongsak , Thammacharoen Sumpun
Published: October 2024

Background and Aim: In tropical regions, the intrusion of saline from seawater (SW) due to global warming and sea level rise in recent years is an important natural factor influencing goat well-being. This study aimed to determine the effects of diluted SW in drinking water on the physiological responses and eating and drinking patterns of crossbred dairy goats under tropical conditions.

Materials and Methods: Twenty dairy goats were divided into four groups (five animals each) based on body weight and milk yield. Animals received either fresh drinking water (SW0.0, control) or diluted SW at concentrations of 0.5% (SW0.5, low salinity), 1% (SW1.0, moderate salinity), and 1.5% (SW1.5, high salinity). The experiment was performed for 49 days (1st–7th week). Throughout this period, daily food and water intake were measured every day. In addition, blood collection was performed on day 25. Total urine and feces were collected from days 25 to 29. Meal and drinking patterns were determined on days 31 and 32.

Results: Salinity did not influence dry matter intake throughout the experiment (p > 0.05). However, SW had a significant effect on eating patterns. The effect of SW on water intake (WI) was pronounced from the 2nd to 7th weeks of this experiment (p < 0.05). The water balance decreased and plasma antidiuretic hormone levels increased from SW1.5 to SW2.5 compared to the other treatments. Rectal temperature and respiration rate increased from 15:00 to 17:00 in SW1.5 patients. The concentrations of plasma electrolyte, creatinine, and heat shock protein 70 did not differ between treatments (p > 0.05). The urinary excretion of Na+ from SW1.5 and K+ and Cl- from SW1.0 was higher than that from SW0.0 and SW0.5 (p < 0.01).

Conclusion: Lactating crossbred goats adapted to low and moderate SW by increasing urine volume and urinary electrolyte excretion (Uex), whereas animals responded to high SW by either increasing Uex or altering drinking patterns to minimize salt stress.

Keywords: antidiuretic hormone, dairy goat, kidney, saline water, water balance.
When and What to Test for Diarrhea: Focus on Stool Testing
Authors: Camilleri Michael
Published: October 2024

INTRODUCTION:

To review stool diagnostic tests in acute and chronic diarrhea.

METHODS:

Narrative review of published literature.

RESULTS:

In acute diarrhea, stool tests are indicated when there is strong pretest probability of infectious etiology or Clostridioides difficile infection suggested by >3 unformed bowel movements per 24 hours, symptoms lasting >7 days, and circumstances that are suggestive of infection. Several commercially available rapid tests for bacterial, viral, or protozoal infections may be offered in addition to traditional methods (e.g. culture, microscopy) and provide a result within 6 hours. For C. difficile infections, a highly sensitive test such as glutamate dehydrogenase test is required; however, this does not distinguish infection from carrier state. That differentiation requires specialized nucleic acid amplification test (for toxin B) or enzyme immunoassays for toxin A or B, which are unfortunately not generally offered by microbiology laboratories. Chronic diarrhea may result from inflammatory, fatty, osmotic, or secretory causes; the commonest cause is diarrhea-predominant irritable bowel syndrome/functional diarrhea. Current recommendations in societal guidelines or clinical practice updates regarding stool tests in diarrhea-predominant irritable bowel syndrome/functional diarrhea in the absence of alarm symptoms include testing for Giardia, calprotectin, fecal immunochemical test, and bile acid diarrhea. Comprehensive stool biochemical analyses (osmolality, pH, electrolytes) differentiate osmotic from secretory diarrhea and identify laxative abuse. Specific stool diagnostic tests for bile acid diarrhea and exocrine pancreatic insufficiency can lead to specific diagnosis and treatments. Surrogate markers associated with high fecal output and rapid transit in chronic diarrhea are stool form and colonic transit.

DISCUSSION:

Fecal testing is still very relevant in the practice of gastroenterology and deserves introduction of advanced microbiological and biochemical tests.
Is ChatGPT a reliable tool in Autoimmune Hepatitis?
Authors: Colapietro Francesca , Piovani Daniele , Pugliese Nicola , Aghemo Alessio , Ronca Vincenzo , Lleo Ana
Published: October 2024

Background and aims:

Artificial intelligence-based chatbots offer a potential avenue for delivering personalized counselling to Autoimmune Hepatitis (AIH) patients. We assessed accuracy, completeness, comprehensiveness and safety of ChatGPT-4 responses to 12 inquiries out of a pool of 40 questions posed by four AIH patients.

Methods:

Questions were categorized into three areas: Diagnosis(1-3), Quality of Life(4-8) and Medical treatment(9-12). 11 Key Opinion Leaders (KOLs) evaluated responses using a Likert scale with 6 points for accuracy, 5 points for safety and 3 points for completeness and comprehensiveness.

Results:

Median scores for accuracy, completeness, comprehensiveness and safety were 5(4-6), 2 (2-2) and 3 (2-3); no domain exhibited superior evaluation. Post-diagnosis follow-up question was the trickiest with low accuracy and completeness but safe and comprehensive features. Agreement among KOLs (Fleiss’s Kappa statistics) was slight for accuracy (0.05) but poor for the remaining features (-0.05, -0.06 and -0,02, respectively).

Conclusions:

Chatbots show good comprehensibility but lack reliability. Further studies are needed to integrate Chat-GPT within clinical practice.
IMPACTO DO MÉTODO PILATES NA FUNÇÃO CARDIORRESPIRATÓRIA E CONDICIONAMENTO FÍSICO DE INDIVÍDUOS COM SÍNDROME PÓS-COVID-19: ENSAIO CLÍNICO RANDOMIZADO
Authors: Ribeiro Hévellen Sharlene Souza , Jorge Matheus Santos Gomes , Schneider Rodolfo Herberto , Wibelinger Lia Mara
Published: October 2024

Objetivo: verificar o impacto do método Pilates na função cardiorrespiratória e condicionamento físico de indivíduos com síndrome pós-COVID-19. Método: Ensaio clínico no qual participaram 39 indivíduos com síndrome pós-COVID-19 randomizados aleatoriamente em dois grupos: 20 no GP (método Pilates) e 19 no GC (orientações domiciliares). Os participantes foram avaliados quanto a função cardiorrespiratória (cirtometria torácica, manovacuometria e microespirometria) e condicionamento físico (teste de caminhada de seis minutos). O GP realizou a intervenção por meio de exercícios aplicados na modalidade solo e com equipamentos (Reformer, Chair, Ladder Barrel e Cadillac), durante oito semanas, com frequência semanal de duas vezes, totalizando 16 sessões (com tempo de 60 minutos cada). O GC recebeu cartilha com orientações domiciliares que deviam ser seguidas no período de oito semanas. Na análise estatística o nível de significância adotado foi de 5%. Resultado: Na análise intragrupos, após a intervenção fisioterapêutica, o GP apresentou aumento da expansibilidade torácica e do condicionamento físico, e redução da percepção de esforço após o teste de caminhada de caminhada de seis minutos (p<0,05), enquanto o GC apresentou aumento da força muscular respiratória (p<0,05). Ainda, houve diferenças entres os grupos no pós-intervenção, onde o GP apresentou menores valores de percepção de esforço em relação ao GC e o GC apresentou maiores valores de força muscular respiratória em relação ao GP (p<0,05). Conclusão: O método Pilates mostra-se como uma estratégia eficaz para melhora da função cardiorrespiratória e condicionamento físico de indivíduos com sequelas decorrentes da COVID-19.
HOMOFOBIA INTERNALIZADA E SAÚDE MENTAL: UMA REVISÃO SISTEMÁTICA
Authors: Cecy David William Pinheiro , Antunes Maria Cristina , Wanderbroocke Ana Claudia Nunes de Souza
Published: October 2024

O objetivo deste artigo é realizar uma revisão sistemática de estudos que analisem a relação entre a homofobia internalizada e indicadores de saúde mental na população LGBTQIA+. Seguindo o protocolo PRISMA, foram consultadas três bases de dados: Web of Science, BVS e Psycinfo. De um total de 1094 artigos selecionados, foram analisados 21 que corresponderam aos critérios de inclusão de ser pesquisa de levantamento que buscou verificar se existia relação entre homofobia internalizada e saúde mental. Os textos demonstraram uma conexão entre a homofobia internalizada e casos de doença mental, bem como a importância dos laços afetivos e das relações familiares. Observa-se que os sintomas de ansiedade, depressão e ideação suicida são mais comuns entre os membros da comunidade LGBTQIA+ e que as dificuldades de socialização e de convivência devido aos ambientes hostis contribuem para a baixa autoestima e o consequente agravamento da saúde mental. Essas pesquisas demonstram a importância do combate à homofobia e da promoção de relações sociais mais acolhedoras, de forma a diminuir o sofrimento de pessoas LGBTQIA+.
NOVAS EVIDÊNCIAS DE VALIDADE E CONFIABILIDADE PARA USO DA ESCALA DE AVALIAÇÃO DA COLABORAÇÃO INTERPROFISSIONAL EM EQUIPE NO BRASIL
Authors: Rossit Rosana Aparecida Salvador , Meireles Everson , Silva Jaqueline Alcântara Marcelino da , Bispo Emanuella Pinheiro de Farias
Published: October 2024

A colaboração interprofissional é um tipo de trabalho que envolve diferentes profissões comprometidas com o desenvolvimento do cuidado, sendo essencial para a qualidade e eficiência da assistência e dos resultados na saúde. O estudo tem por objetivo avançar no processo de validação da Escala de Avaliação da Colaboração Interprofissional na Equipe (AITCS II–BR), por meio da análise de sua dimensionalidade e demonstração de evidências de validade baseadas na estrutura e consistência interna para a utilização no Brasil. Trata-se de um estudo metodológico de validação da AITCS II-BR, a qual refere-se ao construto da colaboração interprofissional, originalmente disseminado em três dimensões: parceria, cooperação e coordenação. Participaram 395 pós-graduandos de cursos em Ensino na Saúde.  Análise fatorial exploratória, análise paralela e de consistência interna foram realizadas. As análises da dimensionalidade da AITCS II-BR-V2 possibilitaram a identificação do índice Kaiser-Meyer-Olkin (KMO=0,96). Obteve-se alta consistência interna noα=0,96). O escore do fator Colaboração obteve média=3,34; desvio-padrão=0,78; mediana=3,39; intervalo de confiança [IC 95% para a média]=3,26 a 3,42; amplitude 1 a 5. Conclui-se que o instrumento é válido, apresenta elevado índice de consistência interna e pode ser aplicado no contexto Brasileiro para avaliação da colaboração interprofissional.
FATORES ASSOCIADOS A ARBOVIROSES AUTORREFERIDAS EM ÁREA DE EXTREMA VULNERABILIDADE SOCIAL EM BRASÍLIA, BRASIL
Authors: Martins Ana Carolina Silva , Andrade Flávia Reis de , Obara Marcos Takashi , Oliveira Max Moura de , Gurgel-Gonçalves Rodrigo , Cruvinel Vanessa Resende Nogueira
Published: October 2024

Este estudo investigou a associação entre fatores ambientais, demográficos e socioeconômicos na área mais pobre de Brasília, capital do Brasil, e a ocorrência de arboviroses autorreferidas. Trata-se de um estudo transversal com abordagem quantitativa incluindo variáveis sociodemográficas, acesso à água e saneamento, esgotamento sanitário e hábitos de vida. Um questionário criado no aplicativo Google Forms foi enviado via celular aos chefes de família que moravam na área Estrutural, que abrigou o maior lixão a céu aberto da América Latina em quase 60 anos. Houve 2.176 respostas, sendo 1.934 (88,9%) mulheres, 1.432 (65,8%) não tinham companheiro, 961 (44,16%) eram sem instrução ou tinham ensino fundamental incompleto e 1.021 (46,92%) relataram ter tido alguma arbovirose. Após a análise ajustada, armazenar água na residência (Odds Ratio - OR 1,58; IC 1,30-1,92), ter conhecimento sobre prevenção de arboviroses (OR 2,22; IC 1,61-3,06) e ser catador de material reciclável (OR 1,84; IC 1,46-2,31) tiveram associação positiva com arbovirose autorreferida, enquanto a coleta de lixo foi fator de proteção (OR - 0,71; IC 0,63-0,92). Observou-se influência de fatores ocupacionais e ambientais nas arboviroses. São necessárias medidas intersetoriais efetivas direcionadas a essa população vulnerável, incluindo capacitação para enfrentamento dessas doenças.
MAPEAMENTO DOS NUTRICIONISTAS QUE ATUAM EM CUIDADOS PALIATIVOS NO BRASIL: PERSPECTIVAS E FRAGILIDADES DE UM CAMPO EM CONSTRUÇÃO
Authors: Santos Rosane de Souza , Silva Isabella Fideles da , Costa Mariana Fernandes , Ferreira Francisco Romão
Published: October 2024

Objetivo: mapear os nutricionistas inseridos nas equipes de Cuidados Paliativos no Brasil e levantar dados sobre a atividade laboral. Método: nutricionistas captados através da ferramenta de busca “onde existem Cuidados Paliativos” do site da Academia Nacional de Cuidados Paliativos, responderam ao questionário entre maio e dezembro de 2021. Resultados: das 85 equipes de Cuidados Paliativos, encontramos 44 nutricionistas e 29 profissionais responderam o nosso questionário. A região Sudeste teve o maior número de nutricionistas participantes (69,0%) e o Nordeste, o menor (3,4%). Os serviços de oncologia foram os que mais empregaram nutricionistas nas suas equipes de Cuidados Paliativos (86,2%) e dentre as atividades que esses nutricionistas desempenham, a avaliação e o diagnóstico nutricional (89,7%), o suporte nutricional (86,2%), o aconselhamento dietético e o planejamento alimentar individualizado (82,8%) foram os mais prevalentes. Em relação ao grau de satisfação, 93,1% dos trabalhadores estavam satisfeitos com trabalho em geral e 86,2% com a remuneração. Observou-se associação positiva entre grau de satisfação geral com a remuneração (p<0,05). Conclusão: o cenário atual é favorável à expansão das equipes de Cuidados Paliativos no Brasil, mas as discussões sobre acesso, distribuição regional e organização desses serviços que incluem a assistência nutricional precisam ser exploradas.
ANÁLISE DAS INTERNAÇÕES E A DISTRIBUIÇÃO ESPACIAL DA ENDOMETRIOSE NO SISTEMA ÚNICO DE SAÚDE SEGUNDO REGIÕES BRASILEIRAS
Authors: Goes Bianca Tereza Oliveira Lima , Soares Mariana Rosa
Published: October 2024

A endometriose é uma afecção ginecológica crônica benigna, estrogênio-dependente, encontrada principalmente em mulheres em idade reprodutiva, porém suas consequências clínicas podem ser diagnosticadas até a pós-menopausa. Objetivo: Analisar a taxa de internação e a distribuição espacial da endometriose segundo as regiões brasileiras entre os anos de 2017 e 2022. Metodologia: Estudo descritivo e ecológico com base em dados de internação por endometriose do Sistema de Informação Hospitalar (SIH). Foram analisadas variáveis sociodemográficas e clínicas, e estimou-se a variação percentual anual e a distribuição espacial das taxas por regiões brasileiras. Resultados: Foram registradas 64.959 internações, com maior proporção de registros na faixa etária de 40 a 49 anos (42,6%), na cor parda (38,4%), com média de internação de 2,4 dias. As maiores taxas foram encontradas na região Sul, com uma taxa de 16,1/100 mil e uma variação percentual anual de 5,5% no período. Na distribuição espacial da taxa média de internações segundo regiões e unidades federativas, houve maior prevalência nos estados do Acre, da Paraíba e de Minas Gerais. Conclusão: Observou-se uma tendência de crescimento das taxas de internações em todas as regiões, com exceção da região Sul, que, no entanto, se manteve com a taxa mais alta do país.
AVANÇOS NA INCLUSÃO ESCOLAR A PARTIR DE UM PROGRAMA DE MONITORIA NO INSTITUTO FEDERAL DE BRASÍLIA
Authors: Alves Cândida Beatriz , Santos Marques Bento Suzane
Published: October 2024

Pessoas com deficiência têm direito a uma educação inclusiva, o que significa estudar em uma classe regular de ensino, com apoio pedagógico para o seu desenvolvimento. Este trabalho teve como objetivo analisar os relatórios de atividades dos monitores no programa de monitoria do Núcleo de Atendimento a Pessoas com Necessidades Específicas do Instituto Federal de Brasília, campus São Sebastião, e suas perspectivas em relação ao atendimento e inclusão de alunos com deficiência na instituição. Participaram da pesquisa sete monitores do programa de monitoria, por meio da escrita do relatório de atividades. A partir de uma análise de conteúdo, os resultados obtidos apontaram para o sucesso do programa, mas chamou a atenção a urgência de que a inclusão escolar seja abraçada por todos os atores da instituição.
Distorção idade-série: levantamentos e caracterização desta situação em três cidades do sul de Minas Gerais
Authors: Góes da Silva Fernanda , Catosso Salles Atílio
Published: October 2024

O artigo buscou fazer um levantamento sobre os indicadores de distorção idade-série em três municípios localizados no Estado de Minas Gerais: Bueno Brandão, Inconfidentes e Ouro Fino. Assim, ao longo deste texto foram abordadas definições sobre a educação básica brasileira a contextualização dos municípios pesquisados e o levantamento e organização dos dados de distorção idade-série destes municípios. A pesquisa apresenta abordagem qualitativa utilizando como metodologia a pesquisa documental e método de coleta de dados secundários quantitativos junto ao banco de dados do Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP), tomando como recorte temporal do período de 2016 a 2020. Não foi objetivo deste artigo procurar compreender os potenciais motivos causadores da distorção idade-série nos três municípios. Isto poderá ser fruto de pesquisas futuras visto que novas indagações foram surgindo ao elaborar este trabalho. Este artigo apresenta um certo ineditismo, pois não há publicações com dados agrupados de distorção idade-série referente aos três municípios pesquisados na forma com que aqui estão sendo apresentados. Os resultados encontrados foram importantes para compreender melhor os dados educacionais bem como o contexto em que estão inseridas as escolas de educação básica dos três municípios.
Evaluation of the Effectiveness of Digitalization Projects in the Field of Citizen Appeals, Considering Regional Specifics
Authors: Begishev Ildar , Abdullayev Ilyоs , Chernov Denis , Blagodatskaya Angelina , Sychanina Svetlana , Kochetkov Evgeniy
Published: October 2024

The article examines the essence, goals and types of citizens' appeals, the procedure for their consideration, as well as the regulatory and organizational support of working with citizens' appeals. The issue of appeals of individuals to the executive bodies of state power in the constituent entity of the Russian Federation was considered in more detail. The problems of implementing digitalization projects in the field of receiving citizens' appeals are considered, the methodology for assessing the effectiveness of the implementation of digitalization projects in the field of receiving citizens' appeals is adapted, taking into account the specifics of the region, a comparative analysis of the implementation of digitalization projects is carried out on the example of the constituent entity of the Russian Federation, comparing the results obtained for 2020-2022.
Indicators Affecting the Strengthening of Mental Activity Among University Students
Authors: Sazonova Tatyana  V . , Nevolina Victoria V. , Ganaeva Elena A. , Saitbaeva Elvira R. , Kriskovets Tatyana N.
Published: October 2024

This article deals with the issue of enhancing the mental activity of students of higher educational institutions during their professional training. We tried to clarify the content of the concept of "mental activity of university students", determine and experimentally investigate the factors influencing its activation. These factors include the humanization and psychologization of the educational process at the university, the creation of a safe socio-psychological environment at the university, the provision of a health-preserving focus of the educational process and the compliance with ergonomic requirements for it, the organization of training students in a cooperation mode and the use of innovative methods and technologies in the classroom that activate the mental activity of students.
Foreign-body granuloma formation in the lower eyelid after injection of poly-D,L-lactic acid as a collagen stimulator: a case report
Authors: Choi Min , Choi Woo Young , Kim Jun Mo , Cheon Ji Seon , Yang Jeong Yeol
Published: October 2024

Poly-D,L-lactic acid (PDLLA) is widely used in facial rejuvenation as a collagen stimulator, with a lower risk of granuloma formation compared to poly-L-lactic acid (PLLA). However, granulomas may still occur. In this case, a 58-year-old woman developed firm, non-tender, bilateral infraorbital granulomas 2 months after her third PDLLA injection for infraorbital hollowing. The lesions were unresponsive to intralesional trichloroacetic acid (TCA) and intense pulsed light therapy, necessitating surgical removal. Histopathological analysis confirmed foreign-body granulomas caused by the PDLLA filler. This case highlights the need for caution when injecting PDLLA into thin-skinned areas like the infraorbital region, where granulomas can be more visible due to limited tissue volume. Although PDLLA fillers are generally safe, granuloma formation remains a potential complication. Early diagnosis and treatment with non-surgical methods, such as intralesional TCA, should be prioritized. If these methods fail, surgical excision, aimed at preserving as much normal tissue as possible, may be necessary for optimal outcomes.
The use of ās- ‘sit’ and vas- ‘dwell’ plus participle and gerund from Early Vedic to Epic Sanskrit
Authors: Grieco Beatrice
Published: October 2024

The auxiliary ās- ‘sit’ is one of a set of verbs that forms iterative-continuative periphrases in Sanskrit, but it has hardly been studied. While modern-day Sanskrit grammars acknowledge its presence, a comprehensive investigation into its usage is lacking. Given the lack of studies on the ās- periphrasis, this paper explores the verbal construction constituted of the root ās- ‘sit’ plus participle or gerund from Early Vedic to Epic Sanskrit, also offering a brief comparison with vas- ‘dwell, live’. A few passages from Vedic prose show vas- in combination with participles and gerunds in a similar use of that with ās-, but these contexts have never been extensively studied in the literature.
Everything you ever wanted to know about cancer stem cells in neuroendocrine neoplasms but were afraid to ask
Authors: Caracuel Ignacio Ruz , Pedraza-Arevalo Sergio , Alonso-Gordoa Teressa , Molina-Cerrillo Javier , Earl Julie , Sainz Bruno
Published: October 2024

While the role of cancer stem cells (CSCs) in tumorigenesis, chemoresistance, metastasis and relapse has been extensively studied in solid tumors, such as adenocarcinomas or sarcomas, the same cannot be said for neuroendocrine neoplasms (NENs). While lagging, CSCs have been described in numerous NENs including gastrointestinal and pancreatic neuroendocrine neoplasms (PanNENs), and they have been found to play critical roles in tumor initiation, progression, and treatment resistance. However, it seems there is still skepticism regarding the role of CSCs in NENs, even in light of studies that support the CSC model in these tumors and the therapeutic benefit of targeting them. For example, in lung neuroendocrine carcinoids, a high percentage of CSCs have been found in atypical carcinoids, suggesting the presence of CSCs in these cancers. In PanNENs, CSCs marked by aldehyde dehydrogenases or CD90 have been identified, and targeting CSCs with inhibitors of molecular pathways has shown therapeutic potential. Overall, while evidence exists for the presence of CSCs in NENs, either the CSC field has neglected NENs or the NEN field has not fully embraced the CSC model. Both might apply and/or may be a consequence of the fact that NENs are a relatively rare and heterogeneous tumor entity, with confusing histology and nomenclature to match. Regardless, this review intends to summarize our current knowledge of CSCs in NENs and highlight the importance of understanding the role of CSCs in the biology of these rare tumors, with a special focus on developing targeted therapies to improve patients' outcomes.
Treatment with BRAF/MEK: inhibitors in mutant BRAF V600E papillary craniopharyngioma
Authors: Erfurth Eva Marie , Siesjö Peter , Sundgren Pia C , Hammar Björn , Kinhult Sara
Published: October 2024

Craniopharyngiomas (CPs) are rare brain epithelial tumours arising in the suprasellar region, infiltrating adjacent areas causing visual loss, panhypopituitarism, cognitive deficits and morbid obesity. Papillary CPs (PCPs) harbour in 94% BRAF mutation cases. Two patients with PCP and BRAF V600E mutations but with different tumour status were treated with BRAF and MEK inhibitors. Case I was diagnosed with biopsy and treated for 16 months with BRAF and MEK inhibitors. After 3.5 months, there was a 50% reduction of the tumour volume, and after 13 months, the tumour volume decreased from 2220 to 90 mm3 (96%). Two months after stopping the drugs, he was treated with fractionated cranial irradiation (54 Gy). No recurrence of the PCP was recorded. Eight months after stopping the drugs, he was diagnosed with an adenocarcinoma of the oesophagus, which led to his death 12 months later. In case II, a woman had had four surgeries due to recurrences of a PCP, and a BRAF V600E mutation was confirmed. After a new recurrence measuring 14 × 12 × 18 mm, she was started on BRAF and MEK inhibitors. After 4 months of treatment, a significant decrease to 8 × 9 × 13 mm was recorded. The treatment continued for 31 months, and the MRI demonstrated a stable unchanged size including scar tissue, with a volume reduction from 633 to 483 mm3. During treatment, her visual acuity improved in her left eye from 0.05 to 0.3. After stopping the drugs, ‘watchful waiting’ with repeated MRI was decided. She is now off treatment for 25 months, without any recurrence on MRI.

Learning points

CPs are rare primary brain epithelial tumours arising in the suprasellar region from remnants of Rathke’s pouch.

CPs infiltrate adjacent areas causing visual loss, panhypopituitarism, cognitive deficits and morbid obesity.

PCPs harbour in >90% BRAF V600E mutation.

BRAF V600E mutation can successfully be treated with the combination of BRAF V600E and Mekinist inhibitors.

It is suggested that PCP patients harbouring BRAF V600E mutation should be offered BRAF V600E and Mekinist inhibitors.
RP, Pronunciation preference polls, dynamic synchrony and SSB Pronunciation
Authors: Akamatsu Tsutomu
Published: October 2024

We first look at various aspects of RP (Received Pronunciation). One particular aspect of RP that is emphasized is its intelligibility (comprehensibility). Reproduced in this connection are results of a survey conducted by a polling organization on ‘intelligibility’ of British English pronunciation varieties. The concept of ‘dynamic synchrony’, as distinct from ‘static synchrony’, is brought in and explained at fair length. With this concept in mind, we look into the fact that many individual British English speakers show preference for different alternative pronunciations of words (e.g. absurd with [‑s‑] or [‑z‑]; 'contribute or con'tribute). We investigate if such different pronunciation choices correlate with ages, i.e. young speakers, old speakers; born before or after such-and-such year? We closely consult all three editions of Longman Pronunciation Dictionary (LPD) compiled by John Christopher Wells which contains detailed results of his 1988 and 1998 pronunciation preference surveys. LPD records pronunciation details found in ‘a modernized version of the type known as Received Pronunciation, or RP [Wells’s block letters]’ (LPD3: xix). Finally there will be a discussion concentrating on Geoffrey Lindsey’s recent book English after RP (2019) which shows the relationship between regressive RP and progressive SSB (Standard Southern British) pronunciation at the present time.
El préstamo participativo: consecuencias prácticas de su contabilidad
Authors: Castillo Iborra Francisco
Published: October 2024

El préstamo participativo se sitúa como una alternativa de financiación viable, sobre todo, para pymes y empresas de nueva creación. La multiplicidad de caracteres que presenta -interés variable, participación del prestamista, amortización anticipada, subordinación o consideración como patrimonio neto- lo configuran como un instrumento atractivo, a la vez que complejo. Merece la pena analizar, por su potencial implicación en la vida societaria, la consideración contable del préstamo como patrimonio neto en los supuestos tasados por el RDL 7/1996 y proceder al debate, aun sucintamente, sobre la posibilidad de realizar una interpretación extensiva a supuestos no recogidos en la norma.
¿Puede construirse un sistema de responsabilidad precontractual? Análisis de los deberes precontractuales y las consecuencias jurí-dicas derivadas de su infracción
Authors: Robert Paula
Published: October 2024

A partir de la Convención de Viena sobre Compraventa Internacional de Mercaderías (1980) el modelo dogmático de responsabilidad contractual adoptado se asienta sobre un concepto unitario de incumplimiento, que comprende todas sus manifestaciones posibles, y, sobre el mismo, articula una serie de remedios (la pretensión de cumplimiento, la reducción del precio, la resolución del contrato, la indemnización de daños y la suspensión del cumplimiento), de forma que esta queda sistematizada. Sin embargo, la responsabilidad precontractual se aborda en nuestro sistema de forma tópica; se ofrece una solución para cada grupo de casos. En este contexto, el trabajo se pregunta por la posibilidad de construir un sistema de responsabilidad precontractual.
Prerequisites for the publication of the Decree on April 17, 1905 “On strengthening the principles of religious tolerance”
Authors: Orlov Maksim
Published: October 2024

This article examines the prerequisites for the publication by Emperor Nicholas II of the decree "On strengthening the principles of religious tolerance". The Russian Empire was a unique multinational and multi-religious state. Until 1905, the laws of the empire established religious tolerance. However, freedom of religion was conditional. Recognized religions had different legal status; freedom of conscience, understood as the right to freely move from one religion to another, was absent. Coverage of this issue is impossible without defining the confessional structure of the Russian Empire, which had developed by the beginning of the XX century. According to the author, there were contradictions within the confessional structure, which became the most important prerequisite for reform. In addition, public discourse has had a significant impact. The society has formed a conviction about the need to lift restrictions on religious freedoms. The liberal wing of public thought included the issue of freedom of conscience in the political program, which translated the demand for the expansion of religious tolerance to a new, political level. Another prerequisite for the reform was the understanding by some officials of the futility of criminal liability against "seducers" and "fallen away". This should also include the work of the higher bureaucracy to mitigate the regime of religious tolerance, which was reflected in the imperial decree of December 12, 1904. Finally, the revolutionary events of 1905 also had an impact on accelerating the course of reform.
Mural synodics in private acts of the second half of the 1560s
Authors: Avdeev Alexander
Published: October 2024

In the paper created within the framework of the scientific project “Corpus Inscriptionum Rossicarum”, examines two komplex of private acts drawn up in the second half of the 60s of the 16th century by a large Dvinsk landowner Alexej Amosov and boyar Alexej Fyodorovich Bas-manov with the mention of a special type of epigraphic monuments of Moscow Russia — wall synodics or memorial tables. These inscriptions, carved in wood or stone, as well as painted with paint, were placed in the sacred part of the temple, on the wall of the altar opposite the sacrifice. These epigaphic monuments were one of the forms of personal piety, and the right to place them was possessed by the сtitors and donators of the temple or monastery. By their request in the wall synodics records the names of the closest relatives and other people not related to the depositors by ties of kinship. The installation of these epigraphic monuments and their placement in the altar be-came a guarantee of eternal commemoration of the persons inscribed in them during the pros-komidia. The heyday of this type of epigraphic monuments falls on the second half of the 17th — second third of the 18th century, but the earlier period of their existence has not yet served as the subject of special scientific research. Based on the analyzed acts, the paper concludes that at the moment the mention of wall synodics in private acts of the second half of the 60s of the 16th century. They are the earliest evidence of the existence of a stable tradition of creating this type of inscriptions, compiled by order of the ctitors and donators.
The first church in Chelyabinsk fortress in the context of the sacralisation of space during the Russian colonisation of the Urals and Siberia
Authors: Koniuchenko Andrey
Published: October 2024

The first temple in the Chelyabinsk fortress in the context of the sacralization of space during the Russian colonization of the Urals and Siberia.The article, on the basis of the sources involved, deals in general terms with the main problems of temple building in the frontier zone in the process of Russian colonization of the Urals and Siberia from the late XVI to the 1730s. Sources are acts of record documentation: decrees, orders, reports. The purpose of the article is to analyze the relationship between state and church structures in temple building. The work is done within the framework of cultural history.The main institutions of the colonization process were the structures of the state and the church, the direct actors were peasants, merchants and servicemen of various categories, and the Posad population. The consolidation of Russia in new territories was carried out through the sacralization of space. The starting point in this process was the construction of the first Orthodox church. Initially, the question of building a temple was raised by both the secular authorities and parishioners, depending on the specific situation. Then the functions of establishing the ecclesiastical and administrative structure were delegated by the center to the field.If earlier the chain looked like this: Orthodox first settlers - the center in Moscow - the royal decree in place of the voivode - implementation, execution of the decision on the spot; then a new link appears at the diocesan level in the person of the bishop. This was caused, first of all, by the increasing scale of colonization, the complication of the secular and ecclesiastical-administrative structure. In the record correspondence, the idea of the impossibility of the existence of an Orthodox person without a temple can be traced.To find out the initiators of the nomination of the first temple in the Chelyabinsk fortress, an analysis of the names of the bishops of the Siberian Metropolis, in charge of which the fortress was located, was undertaken; monks of the Assumption Dalmatian Monastery in 1735, whose archimandrite was instructed to lay the church; the heads of the families of the fortress, recorded in the census of 1739 – 1740. From this it was concluded that the "symphony" of the initiative "from above" and the initiative "from below" was made.