bluuebunny/crossref_metadata_2025 huggingface dataset:
A quantum circuit to generate random numbers within a specific interval
Authors: Orts Francisco , Filatovas Ernestas , Garzón Ester M. , Ortega Gloria
Published: May 2023

Random numbers are of vital importance in fields such as cyptography and scientific simulations. However, it is well known how difficult it is for classical computers to generate random numbers. This is not the case for quantum computers, which are able to genuinely generate random numbers thanks to the property of superposition and their counter-intuitive concept of measurement. However, despite the simplicity of designing a circuit that generates a random number between 0 and$2^{N}-1$2N−1(beingNthe number of available qubits), designing a quantum circuit to generate a number within a specific interval is far from trivial. This paper proposes a customizable circuit design to generate random numbers. The circuit is non- hardware dependent, it allows fault-tolerance, and it can be used by current quantum devices. Therefore, it is a valuable tool for all those quantum applications and algorithms that need to work with random numbers. Moreover, a comparator circuit has also been designed as part of this work. This comparator is the best currently available in the literature in terms of qubits, T-count, and T-depth. It is therefore a useful tool for any other circuit or algorithm where this operation is needed.
Image Resizing for Object Detection: A Learnable Downsampler–Upsampler Pair with Differentiable Image Entropy Estimation
Authors: Dai Chengjie , Chen Qiang , Xu Jingchao , Gong Hanshen , Song Guanghua , Yang Bowei
Published: May 2023

In recent years, super-resolution neural networks have achieved good results in restoring super-resolution images from low-resolution ones. However, most subsequent tasks based on super-resolution images such as object detection are done by the computer. Considering this situation, we propose a learnable downsampler–upsampler pair, which can realize both the downscaling process and the upscaling process by neural networks, and is jointly trained with the YOLOV5 network to optimize the object detection task. Thus, different from existing super-resolution networks, the entire downsampler–upsampler pair is optimized for machine perception. In addition, to further reduce the size of the downsampled images, we also propose a differentiable method for estimating image entropy and add it to the loss function. We verify the effectiveness of our method on the pothole dataset and use scale factors 2× and 4× to prove that our method is capable of diverse resizing levels. The experimental results show that using our learnable downsampler–upsampler pair as a resizing method can highly improve the detection performance compared with other resizing techniques.
DNA Image Encryption Scheme Based on a Chaotic LSTM Pseudo-Random Number Generator
Authors: Koubaâ Karama , Derbel Nabil
Published: May 2023

Deoxyribonucleic Acid (DNA) coding technology is a new research field developed by the combination of computer science and molecular biology, that has been gradually applied in the field of image encryption in recent years. Furthermore, sensitivity to initial conditions, pseudo-random properties, and state ergodicity of coupled chaotic maps can help produce good pseudo-random number generators and meet the requirements of an image encryption system well. In this paper, an image encryption algorithm based on high-dimensional coupled chaotic maps and DNA coding is proposed. A pseudo-random sequence is generated by a long short-term memory (LSTM) architecture using the proposed maps and evaluated through a set of statistical tests to show the high performance of the proposed generator. All intensity values of an input image are converted to a binary sequence, which is scrambled globally by the high-dimensional coupled chaotic maps. The DNA operations are performed on the scrambled binary sequences instead of binary operations to increase the algorithm efficiency. Simulation results and performance analyses demonstrate that the proposed encryption scheme is extremely sensitive to small changes in secret keys, provides high security and can resist differential attack.
Some Jerk Systems with Hidden Chaotic Dynamics
Authors: Li Bingxue , Sang Bo , Liu Mei , Hu Xiaoyan , Zhang Xue , Wang Ning
Published: May 2023

Hidden chaotic attractors is a fascinating subject of study in the field of nonlinear dynamics. Jerk systems with a stable equilibrium may produce hidden chaotic attractors. This paper seeks to enhance our understanding of hidden chaotic dynamics in jerk systems of three variables [Formula: see text] with nonlinear terms from a predefined set: [Formula: see text], where [Formula: see text] is a real parameter. The behavior of the systems is analyzed using rigorous Hopf bifurcation analysis and numerical simulations, including phase portraits, bifurcation diagrams, Lyapunov spectra, and basins of attraction. For certain jerk systems with a subcritical Hopf bifurcation, adjusting the coefficient of a linear term can lead to hidden chaotic behavior. The adjustment modifies the subcritical Hopf equilibrium, transforming it from an unstable state to a stable one. One such jerk system, while maintaining its equilibrium stability, experiences a sudden transition from a point attractor to a stable limit cycle. The latter undergoes a period-doubling route to chaos, which may be followed by a reverse route. Therefore, by perturbing certain jerk systems with a subcritical Hopf equilibrium, we can gain insights into the formation of hidden chaotic attractors. Furthermore, adjusting the coefficient of the nonlinear term [Formula: see text] in certain systems with a stable equilibrium can also lead to period-doubling routes or reverse period-doubling routes to hidden chaotic dynamics. Both findings are significant for our understanding of the hidden chaotic dynamics that can emerge from nonlinear systems with a stable equilibrium.
Late Permian evaporite facies variation in the Forth Approaches Basin, North Sea: implications for hydrogen storage
Authors: Brackenridge Rachel E. , Russell Lauren J. , Hartley Adrian J. , Watson Douglas , Houghton Thomas
Published: May 2023

Hydrogen is expected to play a key role in decarbonizing industry and storing energy from intermittent sources such as wind energy. Underground salt caverns are an attractive target for storage due to their large volumes and effective sealing capacity. Despite ambitious goals to become a world leader in hydrogen, there are no onshore salt basins in Scotland. Therefore, the offshore Forth Approaches Basin (FAB), currently undergoing development of the Seagreen Offshore Wind Farm, could provide a critical storage site. Re-evaluation of petrophysical data from five legacy hydrocarbon wells allowed an updated assessment of the composition and variability of the Late Permian Zechstein evaporite sequence. Well analysis is combined with seismic interpretation to understand the salt bodies and their suitability for solution mining. Three halite formations are identified: (1) the Stassfurt Halite Formation, which has insufficient thickness for solution mining; (2) the Leine Halite Formation, which comprises three subunits with a KCl-dominated unit separating two halite-dominated units; and (3) the Aller Halite Formation, which is only identified in the centre of the FAB. Where halokinesis has occurred, the Leine Halite Formation reaches sufficient thicknesses (>300 m) and purity for salt cavern placement; however, heterogeneities are challenging to predict. Layered evaporites only reach sufficient thickness where the Aller Halite Formation is present and could be developed with the underlying Leine Halite Formation. Heterogeneities can be correlated across wells within the layered sequences, aiding prediction. A strong understanding of evaporite facies distribution is required to ensure that halite bodies are suitable for safe and economic solution mining in the FAB and other salt basins globally.

Thematic collection:
This article is part of the Hydrogen as a future energy source collection available at:
https://www.lyellcollection.org/topic/collections/hydrogen
Evaluating the impact of 4D seismic data artefacts in data assimilation
Authors: Rosa Daiane Rossi , Schiozer Denis Jose , Davolio Alessandra
Published: May 2023

Time-lapse or 4D seismic data are important constraints in reservoir studies because they enable monitoring of saturation and pressure changes that result from hydrocarbon production. 4D seismic data have been quantitatively added, along with production data, in history matching or data assimilation procedures to reduce uncertainty and improve production forecasts. Before performing quantitative studies, it is important to ensure that the 4D seismic data are reliable, with minimal artefacts such as side-lobe effects that can disturb the identification of anomalies. In this work, we propose different ways of treating 4D seismic data in data assimilation for a real reservoir. Explicitly, we evaluated the impact on data assimilation results when considering different amounts of 4D information and three treatments to the identified artefacts. The treatments were: ignoring them, excluding them from data assimilation or defining no seismic changes at their locations. The results show that well and seismic matches are improved when 4D seismic data are assimilated, also improving the production predictions. Despite being a thin reservoir, assimilating two single-layer maps allowed us to predict relevant observed dynamic behaviour, such as the evolved gas trapped in the lower interval. Furthermore, when a treatment was applied to the artefacts, they produced better models than using a single two-layer map (with lower production errors and visually closer impedances to the observed data). Our recommendation is the assimilation of well and 4D seismic data, with the exclusion of unreliable information, for better life-cycle decisions.
Foundations in physiology: an introductory course using the core concepts
Authors: Ball Karen L.
Published: May 2023

This article will detail the development and implementation of an introductory course using the “core concepts.” Specifics of course design, assessment, and challenges encountered will be presented for those interested in this approach.
Novel Degree-Based Topological Descriptors of Fenofibrate Using M-Polynomial
Authors: Kamran Muhammad , Farman Muhammad , Ozon Yildirim Seyma , Delen Sadik , Naci Cangul Ismail , Akram Maria , Pandit M. K.
Published: May 2023

Chemical graph theory is currently expanding the use of topological indices to numerically encode chemical structure. The prediction of the characteristics provided by the chemical structure of the molecule is a key feature of these topological indices. The concepts from graph theory are presented in a brief discussion of one of its many applications to chemistry, namely, the use of topological indices in quantitative structure-activity relationship (QSAR) studies and quantitative structure-property relationship (QSPR) studies. This study uses the M-polynomial approach, a newly discovered technique, to determine the topological indices of the medication fenofibrate. With the use of degree-based topological indices, we additionally construct a few novel degree based topological descriptors of fenofibrate structure using M-polynomial. When using M-polynomials in place of degree-based indices, the computation of the topological indices can be completed relatively quickly. The topological indices are also plotted. Using M-polynomial, we compute novel formulas for the modified first Zagreb index, modified second Zagreb index, first and second hyper Zagreb indices, SK index,

S

K

1

index,

S

K

2

index, modified Albertson index, redefined first Zagreb index, and degree-based topological indices.
Forecasting of Ionospheric Total Electron Content Data Using Multivariate Deep LSTM Model for Different Latitudes and Solar Activity
Authors: Shenvi Nayana , Virani Hassanali
Published: May 2023

The ionospheric state is becoming increasingly important to forecast for the reliable operation of terrestrial and space-based radio-communication systems which are influenced by ionospheric space weather. In this study, we have investigated and tested a multivariate long short-term memory (LSTM) deep learning model for its forecasting accuracy over different latitudinal regions during the solar quiet and solar active years. We also tested its prediction capability during the occurrence of a geomagnetic storm. Four stations qaq1 (60.7°N, 46.04°W), baie (49.18°N, 68.26°W), mas1 (27.76°N, 15.63°W), and bogt (4.64°N, 74.08°W) in the northern hemisphere were used in this study. To optimize the feature extraction process, we used heat map to find the correlation between TEC and the various exogenous parameters and finally nine correlated parameters were used as inputs to train the LSTM model. The performance of the LSTM model was validated by comparing it with the multilayer perceptron (MLP) machine learning algorithm using root mean square error (RMSE) and mean absolute error (MAE) as evaluation indices. The results showed an accuracy improvement of 70% and 64% over MLP during the solar quiet and active years, respectively. The prediction accuracy of our LSTM model was also 74% better than MLP during the geomagnetic storm event. These findings demonstrate the effectiveness of the developed LSTM model and the right selection of the exogenous parameters in estimating TEC, and suggest that this LSTM model can be used for short-term TEC forecasting.
An Unnamed Human Oral Bergeyella sp. as the Cause of an Unusual Bacterial Keratitis
Authors: Petrela Redion B. , Lieberman Joshua A. , Swan Robert T.
Published: May 2023

Purpose. We report a case of bacterial keratitis secondary to an undescribed Bergeyella sp. Bergeyella spp. are not easily cultured, and many reports have identified unculturable isolates through broad-range bacterial polymerase chain reaction (PCR). Observations. A healthy 29-year-old male was attempting to repair an acrylic cannabis water pipe when it shattered and a fragment hit him in the left eye. Two weeks later, he presented with foreign body sensation, scleral injection, and photophobia that were refractory to prolonged corticosteroid therapy. Following a subconjunctival triamcinolone injection, the patient developed a hypopyon and multifocal, midstromal, epithelized corneal infiltrates. Broad-range PCR of the aqueous fluid detected deoxyribonucleic acid closely matching the Bergeyella genus. Empiric treatment directed toward gram-negative bacteria led to the clinical resolution of the inflammation. Conclusions and Importance. This is the first reported case of ocular inflammation secondary to a Bergeyella spp.. As broad-range PCR testing becomes more accessible, we anticipate that additional PCR-positive and culture-negative scenarios will occur.
Blood Eosinophil Count as a Predictive Biomarker of Chronic Obstructive Pulmonary Disease Exacerbation in a Real-World Setting
Authors: Komura Moegi , Sato Tadashi , Suzuki Yohei , Yoshikawa Hitomi , Nitta Naoko Arano , Hayashi Mika , Kuwasaki Eriko , Horikoshi Kimiko , Nishioki Toshihiko , Mori Mikiko , Kodama Yuzo , Sasaki Shinichi , Takahashi Kazuhisa
Published: May 2023

Introduction. Chronic obstructive pulmonary disease (COPD) is the third leading cause of death, and COPD exacerbation worsens the prognosis. Eosinophilic airway inflammation is a COPD phenotype that causes COPD exacerbation and is correlated with peripheral blood eosinophil count. We analyzed real-world data of COPD patients to assess the risk factors of COPD exacerbation focusing on blood eosinophils. Materials and Methods. Patients with COPD who visited our hospital between January 1, 2018, and December 31, 2018, were recruited, and their background information, spirometry data, laboratory test results, and moderate-to-severe exacerbation events during the one-year follow-up period were collected from the electronic medical records and analyzed. The COPD exacerbation risk factors were assessed using univariate and multivariate logistic regression analyses. Results. Twenty-two of 271 (8.1%) patients experienced moderate-to-severe exacerbation. Patients with exacerbation showed worse pulmonary function, and we found that a high blood eosinophil count (≥350 cells/μL;

p
=
0.014

), low % FEV1 (<50%;

p
=
0.002

), increase in white blood cell (≥9000 cells/μL;

p
=
0.039

), and use of home oxygen therapy (

p
=
0.005

) were risk factors for future exacerbations. We also found a strong correlation between eosinophil count cut-offs and exacerbation risk (r = 0.89,

p
<
0.001

). On the other hand, there was no relation between exacerbation risk and inhalation therapy for COPD. Conclusion. In a real-world setting, peripheral blood eosinophil count could be a predictor of future COPD exacerbation.
Characterizing Unipolar and Bipolar Depression by Alterations in Inflammatory Mediators and the Prefrontal-Limbic Structural Network
Authors: Lei Xiaoxia , Ren Juanjuan , Teng Xinyue , Guo Chaoyue , Wu Zenan , Yu Lingfang , Chen Xiaochang , Fu Lirong , Zhang Rong , Wang Dandan , Chen Yan , Zhang Yi , Zhang Chen
Published: May 2023

Objective. The prefrontal-limbic system is closely associated with emotion processing in both unipolar depression (UD) and bipolar depression (BD). Evidence for this link is derived mostly from task-fMRI studies, with limited support from structural findings. Therefore, this study explores the differences in the emotional circuit in these two disorders on a structural, large-scale network basis, coupled with the highly noted inflammatory and growth factors. Methods. In this study, 31 BD patients, 37 UD patients, and 61 age-, sex-, and education-matched healthy controls (HCs) underwent diffusion-weighted imaging (DWI) scanning and serum cytokine sampling. The study compared cytokine levels and prefrontal-limbic network alterations among the three groups and explored potential biological and neurobiological markers to distinguish the two disorders using graph theory, network-based statistics (NBS), and logistic regression. Results. Compared to BD patients, UD patients showed greater s-100β protein levels, higher efficiency of the right amygdala, and significantly elevated prefrontal-cingulate-amygdala subnetwork intensity. Importantly, the altered prefrontal-cingulate-amygdala subnetwork, nodal efficiency of the right amygdala, IL-8, IL-17, and s-100β levels were risk factors for the diagnosis of UD, whereas anxiety symptoms tended to closely correlate with BD. Moreover, binary logistic regression manifested these factors achieved an area under the curve (AUC) of the receiver operating characteristics (ROC) of 0.949, with 0.875 sensitivity and 0.938 specificity in UD vs. BD classification. Conclusions. These findings narrow the gap in the structural network of emotional circuits in bipolar and unipolar depression, pointing to distinct emotion-processing mechanisms in both disorders.
Cross-Border Travel Behavior Analysis of Hong Kong-Zhuhai-Macao Bridge Using MXL-BMA Model
Authors: Zou Yajie , Han Wanbing , Lin Bo , Wu Bing , Li Linbo , Wu Shubo , Abid Malik Muneeb
Published: May 2023

The Hong Kong-Zhuhai-Macao Bridge (HZMB) is an important transportation facility connecting Hong Kong, Zhuhai, and Macao. Thus, analyzing the characteristics of cross-border behavior becomes crucial for enhancing the smart travel experience of the HZMB. Discrete choice models (e.g., logit models) are commonly used to describe travel mode choice behavior. Multinomial logit (MNL) is subjected to the independence of irrelevant alternatives (IIA) assumption. Nested logit (NL) model does not consider the heterogeneity of travel individuals. Mixed logit (MXL) model can overcome the above limitations, but it may neglect model uncertainty. Therefore, a Bayesian model averaging (BMA) approach is applied to model travel mode choice behavior considering using revealed preference/stated preference (RP/SP) fusion data collected by questionnaires online. A structural equation model (SEM) is adopted to explore the potential relationship between latent variables, and two travel modes (i.e., cross-border bus and cross-border private car) are selected to analyze the cross-border travel mode choice of the HZMB. The results reveal that the MXL-BMA approach can better explain the cross-border travel mode choice behavior. And the transportation modes arriving and departing the HZMB have a significant impact on the travel mode choice of the HZMB. The findings of this study can provide suggestions for designing personalized travel services for travelers across the HZMB.
The Impact of Maternal Age and Educational Level on Developmental Dysplasia of the Hip Diagnosis and Screening: A Descriptive Comparative Study
Authors: Dawod Moh’d S. , Alswerki Mohammad N. , Abuqudiri Amr Z. , Albadaineh Ashraf A. , Mahmoud Leena M. , Altarawneh Dania J. , Rbeihat Nour H. , Alkhanazreh Rogayah M.
Published: May 2023

Background. Early and proper screening for developmental dysplasia of the hip (DDH) is very critical to prevent catastrophic complication on the developing hip joint. Many factors (either maternal or child-related) that hinder timely DDH screening have been previously investigated. Methods. A cross-sectional descriptive study design was adopted. 175 babies presented for DDH screening coming with their mothers were investigated. Maternal age, age group, and educational level were recorded. In addition, multiple child-related variables such as age of screening, gender, positive family history, preterm delivery, and mode of delivery were recorded as well. Analysis for association between delayed vs. early screening was made against the maternal and the child-related variables. Results. A total number of 175 children with their mothers were investigated. The mean maternal age was 27.9 years, about one third of the mothers had a graduate level of education (36.3%), while 41.1% had high school education, and 22.3% had middle school education. On the other hand, 40.0% of the investigated babies were first born and two thirds of our sample babies were females (66.9%). Of the included babies, 100 (57.1%) were screened at the appropriate 4-month age, while 75 (42.9%) missed the 4-month screening. Chi-square analysis showed that delayed DDH screening was associated with a lower maternal educational level (

P

 ≤ 0.001), younger maternal age (

P

 ≤ 0.001), and first born baby (

P

 ≤ 0.001). Positive family history was protective against delayed DDH screening (

P

 = 0.032). Conclusion. The lower maternal educational level, younger maternal age group, and first born babies are risk factors for delayed DDH screening.
Effect of Metakaolin on the Diffusion Properties of Chloride Ions in Cement Mortar under the Coupling Effect of Multiple Factors in Marine Environment
Authors: Yuan Yezhen , Niu Kaimin , Tian Bo , Kong Lijuan , Li Lihui
Published: May 2023

To address the problem of chloride ion transport in cement concrete in marine environment, this study investigates the effect of metakaolin dosage on the chloride ion diffusion resistance of mortar and its mechanism by testing the chloride ion binding capacity and microstructure of mortar under the coupling effect of chlorine salt-sulfate-carbonation multiple factors. The results show that the coupling of sulfate or carbonation reduces chloride ion transport to some extent compared with single chlorine salt attack, while the three-factor coupled environment promotes free chloride ion diffusion. This is because the products of calcium alumina, gypsum, and calcium carbonate grow together and compete with each other to form more large capillaries; thus, accelerating the diffusion of chloride ions in cement mortar. Metakaolin, due to its higher pozzolanic activity, increases the monocarbon aluminate content in the erosion products, promotes F-salt generation, and increases the Al/Si ratio, which strengthens the binding ability of C-S-H gel to chloride ions, so the free chloride ion concentration inside the specimens doped with metakaolin is lower. In particular, the three-factor coupled environment has less 0.05–10 μm capillary pore content and higher F-salt stability in the specimens, which has the strongest effect on chloride ion curing, and the free chloride ion concentration integral in M-SCCl is reduced by nearly 30% compared with MF-SCCl and F-SCCl.
Supplementary Table S6 from CD49d Expression Identifies a Biologically Distinct Subtype of Chronic Lymphocytic Leukemia with Inferior Progression-Free Survival on BTK Inhibitor Therapy
Authors: Alsadhan Anfal , Chen Jonathan , Gaglione Erika M. , Underbayev Chingiz , Tuma Pamela L. , Tian Xin , Freeman Lita A. , Baskar Sivasubramanian , Nierman Pia , Soto Susan , Itsara Andy , Ahn Inhye E. , Sun Clare , Bibikova Elena , Hartmann Tanja Nicole , Mhibik Maissa , Wiestner Adrian
Published: May 2023

Supplementary Table S6. DEGs for Baseline Comparison of CD49d+ and CD49d
Supplementary Table S3 from CD49d Expression Identifies a Biologically Distinct Subtype of Chronic Lymphocytic Leukemia with Inferior Progression-Free Survival on BTK Inhibitor Therapy
Authors: Alsadhan Anfal , Chen Jonathan , Gaglione Erika M. , Underbayev Chingiz , Tuma Pamela L. , Tian Xin , Freeman Lita A. , Baskar Sivasubramanian , Nierman Pia , Soto Susan , Itsara Andy , Ahn Inhye E. , Sun Clare , Bibikova Elena , Hartmann Tanja Nicole , Mhibik Maissa , Wiestner Adrian
Published: May 2023

Supplementary Table S3: Representativeness of Study Participants
Supplementary Figure S1 from Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial
Authors: Abel Melissa L. , Takahashi Nobuyuki , Peer Cody , Redon Christophe E. , Nichols Samantha , Vilimas Rasa , Lee Min-Jung , Lee Sunmin , Shelat Meenakshi , Kattappuram Robbie , Sciuto Linda , Pinkiert Danielle , Graham Chante , Butcher Donna , Karim Baktiar , Sharma Ajit Kumar , Malin Justin , Kumar Rajesh , Schultz Christopher W. , Goyal Shubhank , del Rivero Jaydira , Krishnamurthy Manan , Upadhyay Deep , Schroeder Brett , Sissung Tristan , Tyagi Manoj , Kim Jung , Pommier Yves , Aladjem Mirit , Raffeld Mark , Figg William Douglas , Trepel Jane , Xi Liqiang , Desai Parth , Thomas Anish
Published: May 2023

Berzosertib pharmacodynamic assessment
Supplementary Data S1 from Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial
Authors: Abel Melissa L. , Takahashi Nobuyuki , Peer Cody , Redon Christophe E. , Nichols Samantha , Vilimas Rasa , Lee Min-Jung , Lee Sunmin , Shelat Meenakshi , Kattappuram Robbie , Sciuto Linda , Pinkiert Danielle , Graham Chante , Butcher Donna , Karim Baktiar , Sharma Ajit Kumar , Malin Justin , Kumar Rajesh , Schultz Christopher W. , Goyal Shubhank , del Rivero Jaydira , Krishnamurthy Manan , Upadhyay Deep , Schroeder Brett , Sissung Tristan , Tyagi Manoj , Kim Jung , Pommier Yves , Aladjem Mirit , Raffeld Mark , Figg William Douglas , Trepel Jane , Xi Liqiang , Desai Parth , Thomas Anish
Published: May 2023

Trial protocol dose limiting toxicity criteria
Supplementary Fig. 4 from Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial
Authors: Orgel Etan , Knight Kristin R. , Chi Yueh-Yun , Malvar Jemily , Rushing Teresa , Mena Victoria , Eisenberg Laurie S. , Rassekh Shahrad R. , Ross Colin J.D. , Scott Erika N. , Neely Michael , Neuwelt Edward A. , Muldoon Leslie L. , Freyer David R.
Published: May 2023

Supplementary Fig. 4 Evaluation of long-term storage of serum specimens (NAC assay)
Supplementary Fig. 1 from Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial
Authors: Orgel Etan , Knight Kristin R. , Chi Yueh-Yun , Malvar Jemily , Rushing Teresa , Mena Victoria , Eisenberg Laurie S. , Rassekh Shahrad R. , Ross Colin J.D. , Scott Erika N. , Neely Michael , Neuwelt Edward A. , Muldoon Leslie L. , Freyer David R.
Published: May 2023

Supplementary Fig. 1 Treatment schema & Sampling Timepoints
Supplementary Data 1 from Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial
Authors: Orgel Etan , Knight Kristin R. , Chi Yueh-Yun , Malvar Jemily , Rushing Teresa , Mena Victoria , Eisenberg Laurie S. , Rassekh Shahrad R. , Ross Colin J.D. , Scott Erika N. , Neely Michael , Neuwelt Edward A. , Muldoon Leslie L. , Freyer David R.
Published: May 2023

Supplemental Tables and Files
Supplementary Figure S8 from Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
Authors: Luke Jason J. , Piha-Paul Sarina A. , Medina Theresa , Verschraegen Claire F. , Varterasian Mary , Brennan Aoife M. , Riese Richard J. , Sokolovska Anna , Strauss James , Hava David L. , Janku Filip
Published: May 2023

Supplemental Figure 8. Representative immunofluorescence images for patient 200-003 and 100-005.
Supplementary Figure S7 from Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
Authors: Luke Jason J. , Piha-Paul Sarina A. , Medina Theresa , Verschraegen Claire F. , Varterasian Mary , Brennan Aoife M. , Riese Richard J. , Sokolovska Anna , Strauss James , Hava David L. , Janku Filip
Published: May 2023

Supplemental Figure 7. Quantification of immune cell composition in selected tumors determined by immunofluorescence multi-plex assay.
Supplementary Figure S4 from Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
Authors: Luke Jason J. , Piha-Paul Sarina A. , Medina Theresa , Verschraegen Claire F. , Varterasian Mary , Brennan Aoife M. , Riese Richard J. , Sokolovska Anna , Strauss James , Hava David L. , Janku Filip
Published: May 2023

Supplemental Figure 4. SYNB1891 increases IFN-stimulated gene expression in mouse tumors.
Supplementary Figure S3 from Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
Authors: Luke Jason J. , Piha-Paul Sarina A. , Medina Theresa , Verschraegen Claire F. , Varterasian Mary , Brennan Aoife M. , Riese Richard J. , Sokolovska Anna , Strauss James , Hava David L. , Janku Filip
Published: May 2023

Supplemental Figure 3. Serum cytokine levels in subjects receiving SYNB1891
Supplementary Figure S2 from Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
Authors: Luke Jason J. , Piha-Paul Sarina A. , Medina Theresa , Verschraegen Claire F. , Varterasian Mary , Brennan Aoife M. , Riese Richard J. , Sokolovska Anna , Strauss James , Hava David L. , Janku Filip
Published: May 2023

Supplemental Figure 2. Design of the SYNB1891 Phase 1 study.
Supplemental Fig. S1 from Clonal Hematopoiesis in Young Women Treated for Breast Cancer
Authors: Gibson Christopher J. , Fell Geoffrey , Sella Tal , Sperling Adam S. , Snow Craig , Rosenberg Shoshana M. , Kirkner Greg , Patel Ashka , Dillon Deborah , Bick Alexander G. , Neuberg Donna , Partridge Ann H. , Miller Peter G.
Published: May 2023

All Clonal Hematopoiesis in the YWS
Data from RE-MIND: Comparing Tafasitamab + Lenalidomide (L-MIND) with a Real-world Lenalidomide Monotherapy Cohort in Relapsed or Refractory Diffuse Large B-cell Lymphoma
Authors: Zinzani Pier Luigi , Rodgers Thomas , Marino Dario , Frezzato Maurizio , Barbui Anna Maria , Castellino Claudia , Meli Erika , Fowler Nathan H. , Salles Gilles , Feinberg Bruce , Kurukulasuriya Nuwan C. , Tillmanns Sascha , Parche Stephan , Dey Debarshi , Fingerle-Rowson Günter , Ambarkhane Sumeet , Winderlich Mark , Nowakowski Grzegorz S.
Published: May 2023

AbstractPurpose:
Tafasitamab, an Fc-modified, humanized, anti-CD19 monoclonal antibody, in combination with lenalidomide, demonstrated efficacy in transplant-ineligible patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), in the single-arm, phase II L-MIND study (NCT02399085). RE-MIND, a retrospective observational study, generated a historic control for L-MIND to delineate the contribution of tafasitamab to the efficacy of the combination.
Patients and Methods:
Data were retrospectively collected from patients with R/R DLBCL treated with lenalidomide monotherapy for comparison with tafasitamab + lenalidomide–treated patients (L-MIND). Key eligibility criteria were aligned with L-MIND. Estimated propensity score–based Nearest Neighbor 1:1 Matching methodology balanced the cohorts for nine prespecified prognostic baseline covariates. The primary endpoint was investigator-assessed best overall response rate (ORR). Secondary endpoints included complete response (CR) rate, progression-free survival (PFS), and overall survival (OS).
Results:
Data from 490 patients going through lenalidomide monotherapy were collected; 140 qualified for matching with the L-MIND cohort. The primary analysis included 76 patients from each cohort who received a lenalidomide starting dose of 25 mg/day. Cohort baseline covariates were comparable. A significantly better ORR of 67.1% (95% confidence interval, 55.4–77.5) was observed for the combination therapy versus 34.2% (23.7–46.0) for lenalidomide monotherapy [odds ratio, 3.89 (1.90–8.14); P < 0.0001]. Higher CR rates were achieved with combination therapy compared with lenalidomide monotherapy [39.5% (28.4–51.4) vs. 13.2% (6.5–22.9)]. Survival endpoints favored combination therapy. Lenalidomide monotherapy outcomes were similar to previously published data.
Conclusions:
RE-MIND enabled the estimation of the additional treatment effect achieved by combining tafasitamab with lenalidomide in patients with R/R DLBCL.
TABLE 1 from Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells
Authors: Islam S.M. Rafiqul , Maeda Takuya , Tamaoki Naritaka , Good Meghan L. , Kishton Rigel J. , Paria Biman C. , Yu Zhiya , Bosch-Marce Marta , Bedanova Nicole M. , Liu Chengyu , Kruhlak Michael J. , Restifo Nicholas P. , Vizcardo Raul
Published: May 2023

The list of antibodies used in the study
Figure S2 from Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells
Authors: Islam S.M. Rafiqul , Maeda Takuya , Tamaoki Naritaka , Good Meghan L. , Kishton Rigel J. , Paria Biman C. , Yu Zhiya , Bosch-Marce Marta , Bedanova Nicole M. , Liu Chengyu , Kruhlak Michael J. , Restifo Nicholas P. , Vizcardo Raul
Published: May 2023

Figure S2: Newly identified TCRs in TIL-iPSCs established from patient 4069 TIL by αCD3/28 Ab stimulation
Figure S1 from Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells
Authors: Islam S.M. Rafiqul , Maeda Takuya , Tamaoki Naritaka , Good Meghan L. , Kishton Rigel J. , Paria Biman C. , Yu Zhiya , Bosch-Marce Marta , Bedanova Nicole M. , Liu Chengyu , Kruhlak Michael J. , Restifo Nicholas P. , Vizcardo Raul
Published: May 2023

Figure S1: A summary table of the patient samples used and the schema of the study
FIGURE 3 from Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells
Authors: Islam S.M. Rafiqul , Maeda Takuya , Tamaoki Naritaka , Good Meghan L. , Kishton Rigel J. , Paria Biman C. , Yu Zhiya , Bosch-Marce Marta , Bedanova Nicole M. , Liu Chengyu , Kruhlak Michael J. , Restifo Nicholas P. , Vizcardo Raul
Published: May 2023

TIL-tumor cell coculture resulted in establishment of TIL-iPSCs from tumor-reactive T-cell clones. A, Schematic representation of TIL-tumor cell coculture to isolate tumor-reactive T cells and subsequent reprogramming into iPSCs. Autologous tumor cell line and minimally cultured TIL were cocultured for 16 hours, sorted for PD1+ 4-1BB+ CD8+ T cells, and transduced with Sendai virus containing four Yamanaka factors and SV40 large T antigen. On days 20–21 when cells formed domed shaped ES cell-like colonies, they were individually collected as clones and expanded. B, A summary table of nine different TCRs identified from 13 different master tubes containing 221 TIL-iPSC clones by using immunosequencing analysis. CDR3β amino acid sequence, Vβ family, frequency in bulk (before coculture in starting material) and in sorted PD1+ 4-1BB+ (DP) population, enrichment (DP/Bulk), the least number of iPSC clones established and the type of TCR were noted. PIR, preidentified reactive TCR; NF, newly found TCR (unknown reactivity). C, A summary table of the TCRβ sequence analysis of six preidentified tumor-reactive TCRs (PIR-TCR I–VI) indicating the CDR3β amino acid sequence, Vβ family, frequency in bulk (before coculture) and in the sorted PD1+ 4-1BB+ (DP) population after TIL-tumor cell coculture, enrichment (DP/Bulk) and presence in established iPSC clones. * means the TCR was not found in established T-iPSC clones but detected in the remaining clones in the dish after picking up iPS cell colonies (mother dish). D, A graph indicates the frequency of PIR-TCRs in starting cells (Bulk) and in sorted PD1+ 4-1BB+ (DP) cells. E, A bar graph indicates the enrichment analysis (the ratio of DP/Bulk) of those six PIR-TCRs.
Figure S4 from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring
Authors: Nakhle Jean , Khattar Khattar , Özkan Tülin , Boughlita Adel , Abba Moussa Daouda , Darlix Amelie , Lorcy Frédérique , RIGAU Valérie , BAUCHET Luc , Gerbal-Chaloin Sabine , Daujat-Chavanieu Martine , Bellvert Floriant , Turchi Laurent , Virolle Thierry , Hugnot Jean-Philippe , Buisine Nicolas , Galloni Mireille , Dardalhon Valerie , Rodriguez Anne-Marie , Vignais Marie-Luce
Published: May 2023

Metabolites produced by GSCs following MSC mitochondria acquisition and TMZ treatment
Figure S3 from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring
Authors: Nakhle Jean , Khattar Khattar , Özkan Tülin , Boughlita Adel , Abba Moussa Daouda , Darlix Amelie , Lorcy Frédérique , RIGAU Valérie , BAUCHET Luc , Gerbal-Chaloin Sabine , Daujat-Chavanieu Martine , Bellvert Floriant , Turchi Laurent , Virolle Thierry , Hugnot Jean-Philippe , Buisine Nicolas , Galloni Mireille , Dardalhon Valerie , Rodriguez Anne-Marie , Vignais Marie-Luce
Published: May 2023

Effects of MSC mitochondria on GSCs metabolic response to TMZ (A, B) GSC mitochondrial mass and ROS production. FACS analysis of MitoTracker and MitoSox-labeled GSCs after the acquisition of MSC mitochondria and TMZ treatment (24 hr). (A) Mitochondrial mass. (B) ROS production. (A, B) Representative experiments and relative MFI values (mean ± SEM; n=3). One-way ANOVA, *p < 0.05. (C) Expression of Cytochrome c oxidase IV (COX IV). Representative Western blot with the corresponding membrane (MW markers in kDa) as shown in Fig. 3H.
Entrevista com José d’Encarnação: toponímia portuguesa e Epigrafia Romana, ou uma aventura ao passado mediada pelos nomes de lugares
Authors: D’Encarnação José , Carvalhinhos Patricia , Soares Mônica
Published: May 2023

A toponímia portuguesa é, simultaneamente, similar e muito diferente da toponímia brasileira. Apesar de ser o substrato de boa parte dos nomes de lugares no Brasil, a toponímia portuguesa é peculiar pela própria história da constituição de Portugal como nação, uma estrada que já era percorrida há pelo menos mil anos na época das grandes navegações. José d'Encarnação nos oferece, por meio de seu olhar de pesquisador que tropeça em topônimos diariamente, um pouco desse percurso histórico e linguístico. É uma entrevista saborosa, como um prato já conhecido que sabe diferente porque lhe são acrescidos outros ingredientes.
Quartet of APOCs and the Different Roles They Play in Diabetes
Authors: Hsu Cheng-Chieh , Kanter Jenny E. , Kothari Vishal , Bornfeldt Karin E .
Published: May 2023

APOA1 and APOB are the structural proteins of high-density lipoprotein and APOB-containing lipoproteins, such as low-density lipoprotein and very low-density lipoprotein, respectively. The 4 smaller APOCs (APOC1, APOC2, APOC3, and APOC4) are exchangeable apolipoproteins; they are readily transferred among high-density lipoproteins and APOB-containing lipoproteins. The APOCs regulate plasma triglyceride and cholesterol levels by modulating substrate availability and activities of enzymes interacting with lipoproteins and by interfering with APOB-containing lipoprotein uptake through hepatic receptors. Of the 4 APOCs, APOC3 has been best studied in relation to diabetes. Elevated serum APOC3 levels predict incident cardiovascular disease and progression of kidney disease in people with type 1 diabetes. Insulin suppresses APOC3 levels, and accordingly, elevated APOC3 levels associate with insulin deficiency and insulin resistance. Mechanistic studies in a mouse model of type 1 diabetes have demonstrated that APOC3 acts in the causal pathway of diabetes-accelerated atherosclerosis. The mechanism is likely due to the ability of APOC3 to slow the clearance of triglyceride-rich lipoproteins and their remnants, thereby causing an increased accumulation of atherogenic lipoprotein remnants in lesions of atherosclerosis. Less is known about the roles of APOC1, APOC2, and APOC4 in diabetes.
HDL Function and Atherosclerosis: Reactive Dicarbonyls as Promising Targets of Therapy
Authors: Linton MacRae F. , Yancey Patricia G. , Tao Huan , Davies Sean S.
Published: May 2023

Epidemiologic studies detected an inverse relationship between HDL (high-density lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular disease (ASCVD), identifying HDL-C as a major risk factor for ASCVD and suggesting atheroprotective functions of HDL. However, the role of HDL-C as a mediator of risk for ASCVD has been called into question by the failure of HDL-C–raising drugs to reduce cardiovascular events in clinical trials. Progress in understanding the heterogeneous nature of HDL particles in terms of their protein, lipid, and small RNA composition has contributed to the realization that HDL-C levels do not necessarily reflect HDL function. The most examined atheroprotective function of HDL is reverse cholesterol transport, whereby HDL removes cholesterol from plaque macrophage foam cells and delivers it to the liver for processing and excretion into bile. Indeed, in several studies, HDL has shown inverse associations between HDL cholesterol efflux capacity and ASCVD in humans. Inflammation plays a key role in the pathogenesis of atherosclerosis and vulnerable plaque formation, and a fundamental function of HDL is suppression of inflammatory signaling in macrophages and other cells. Oxidation is also a critical process to ASCVD in promoting atherogenic oxidative modifications of LDL (low-density lipoprotein) and cellular inflammation. HDL and its proteins including apoAI (apolipoprotein AI) and PON1 (paraoxonase 1) prevent cellular oxidative stress and LDL modifications. Importantly, HDL in humans with ASCVD is oxidatively modified rendering HDL dysfunctional and proinflammatory. Modification of HDL with reactive carbonyl species, such as malondialdehyde and isolevuglandins, dramatically impairs the antiatherogenic functions of HDL. Importantly, treatment of murine models of atherosclerosis with scavengers of reactive dicarbonyls improves HDL function and reduces systemic inflammation, atherosclerosis development, and features of plaque instability. Here, we discuss the HDL antiatherogenic functions in relation to oxidative modifications and the potential of reactive dicarbonyl scavengers as a therapeutic approach for ASCVD.
Tenecteplase in Acute Stroke: What About the Children?
Authors: Sun Lisa R. , Wilson Jenny L. , Waak Michaela , Kiskaddon Amy , Goldenberg Neil A. , Jordan Lori C. , Barry Megan
Published: May 2023

Tenecteplase is replacing alteplase as the fibrinolytic agent of choice for the acute management of ischemic stroke in many adult stroke centers due to practical and pharmacokinetic advantages in the setting of similar outcomes. Although thrombolytic use is increasing for acute childhood stroke, there is very limited experience with tenecteplase in children for any indication, and importantly, there are no data on safety, dosing, or efficacy of tenecteplase for childhood stroke. Changes in fibrinolytic capacity over childhood, pediatric pharmacological considerations such as age-specific differences in drug clearance and volume of distribution, and practical aspects of drug delivery such as availability in children’s hospitals may impact decisions about transitioning from alteplase to tenecteplase for acute pediatric stroke treatment. Pediatric and adult neurologists should prepare institution-specific guidelines and organize prospective data collection.
“Dancing with Atoms”: A Tribute to Sheila Tinney
Authors: Knight Silvin P. , Refojo José , Newman Louise , Rizzo Rossella , Tinney Hugh , Romero-Ortuno Roman
Published: May 2023

The authors present a short dynamic visualization titled “Dancing with Atoms,” produced in honor of the late Irish mathematical physicist Sheila Tinney (1918–2010), the first Irish-born and -raised woman to receive a doctorate in the mathematical sciences. The visualization is inspired by Tinney’s groundbreaking work on crystal lattice vibrations and consists of an animation showing an atomic lattice structure vibrating based on data derived from a musical piece performed by her son, award-winning pianist Hugh Tinney. The acoustic signal processing and visualization were conducted using the new Science Foundation Ireland–funded “Tinney” high-performance computing cluster in Trinity College Dublin, Ireland.
Capturing the Beauty of Bubble Shadows and Exploring Their
Regularity
Authors: Miller Brad , Rosso Diego
Published: May 2023

An artist (Brad Miller) and an engineering researcher (Diego Rosso) met at a common point: their interest in bubbles. Miller is a visua artist whose interest in bubbles has evolved over several decades. He has developed unique ways of capturing bubbles’ mesmerizing and mysterious patterns both photographically and, more uniquely by making the high-resolution photograms of bubbles shown in this paper, allowing for detailed observation of their geometry, etc Rosso has observed the physical laws at work in these bubble patterns and distills the essence of these laws in this manuscript. This paper highlights some of their shared thoughts about what is revealed through these images.
Creative Futuring for More-Than-Human Worlds: Exhibitions as Sites to
Ponder Environmental Governance
Authors: Sheikh Hira , Deary Isabella , Davies Lowana-Skye , Davies Merinda , Foth Marcus , Mitchell Peta
Published: May 2023

The article presents the Smart Urban Governance for More-than-Human Future(s) anthology, comprising six speculative creative works. It draws on techniques of futuring as a methodology to explore how creative practice as an act of futuring and exhibitions as sites to ponder environmenta governance can empower more-than-human futures. Reporting on participatory observations and semistructured interviews with the exhibition audience the article posits that creative futuring can empower futures by developing awareness that environmental governance can facilitate nonhuman agencies that conserve and repair the ecological world.