bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of Chronic Myeloid Leukemia Patients During Pregnancy (Analysis of Literature and Practical Recommendations)
Authors: Chelysheva Ekaterina Yur'evna , Turkina A.G. , Polushkina E.S. , Vinogradova M.A. , Shmakov R.G.
Published: March 2019

Background. The tyrosine kinase inhibitors (TKI) era is marked by a long-term favorable prognosis of chronic myeloid leukemia (CML). In this context CML patients of reproductive age are faced with major issues of family planning with due regard to the risk of TKI treatment interruption during pregnancy. Additionally, TKI impact is another potential risk to the fetus. Aim. To develop differentiated approach to CML treatment during pregnancy. Materials & Methods. Analysis includes literature data and clinical experience based on 166 pregnancies of 120 CML patients from CML Pregnancy Registry. Results. Pregnancy planning is recommended after achieving stable and deep molecular response (with BCR-ABL > 0.01 %, IS) within the period of at least 2 years. At conception TKI therapy does not have to be interrupted. However, early pregnancy detection and TKI treatment interruption after pregnancy confirmation are of vital importance due to teratogenic risks. Furthermore, no TKI may be administered during organogenetic period, i.e. up to the 15th week of gestation. In the absence or loss of complete hematologic response and growth of BCR-ABL > 1 % after the 15th week of gestation imatinib or nilotinib administration is justified in the interest of pregnant patients taking into account limited transfer of these drugs through placenta. In the absence of complete hematologic response before the 15th week of gestation interferon-а can be administered. With BCR-ABL < 1 % patients can be either followed-up without therapy or they can receive interferon-а throughout pregnancy. Dasatinib, bosutinib, and other TKI are contraindicated at any stage of pregnancy. There are no special recommendations for childbirth, delivery is to be adapted to obstetric conditions. Breast feeding is not recommended because of the lack of practical evidence for its safety. Conclusion. A regular molecular monitoring of BCR-ABL and hematologic status is indispensable, health condition of fetus should be continuously monitored as well. CML patient management should be conducted by cooperating hematologists and gynecologists.
Rhythm and Conduction Disorders in Patients Receiving Ibrutinib
Authors: Emelina E.I. , Gendlin Gennadii Efimovich , Nikitin I.G. , Dmitrieva E.A. , Nikitin E.A. , Ptushkin V.V.
Published: March 2019

Aim. Early diagnosis and treatment of rhythm and conduction disorders in patients receiving ibrutinib. Materials & Methods. The trial included 206 patients with indications for ibrutinib, 193 of them are at different stages of treatment from 1.5 to 51 months. The trial enrolled the patients with chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's macroglobulinemia, aged 59 to 72 years (with median age of 66 years): 70 women aged 54 to 71 years (with median age of 64 years), and 123 men aged 60 to 72 years (with median age of 66 years). For early detection of rhythm and conduction disorders all the patients received ECG monitoring and 24-hour Holter ECG monitoring. Results. Atrial fibrillation (AF) was identified in 21 (12 %) patients during ibrutinib therapy period of 1 to 24 months. Most often AF is registered within the first 6 months of ibrutinib therapy. Before its administration 18 (10.5 %) patients had history of prior AF. Thus, a total of 39 ibrutinib recipients with AF are followed-up. According to CHA2DS2-VASc 27 (69 %) of them have an indication for anticoagulant treatment. Severe atrioventricular block was diagnosed in 2 (1 %) patients that necessitated a pacemaker. In 2 (1 %) female patients severe supraventricular tachycardia with up to 295 BPM was registered which required ablation. In a patient with permanent atrial fibrillation rhythm pauses were identified and a pacemaker was installed. Conclusion. The presence of AF in ibrutinib recipients is not a withdrawal criterion and does not require ibrutinib therapy to be discontinued. Anticoagulants were administered to patients with AF according to existing guidelines in compliance with CHA2DS2-VASc which had to be approached with caution and required dynamic monitoring of patients. Severe rhythm and conduction disorders in ibrutinib recipients arise in rare cases (2 %). Such patients require cardiac surgery with subsequent ibrutinib treatment without dose reduction. Timely diagnosis and the correction of rhythm and conduction allow to avoid changing of antitumor therapy plan.
Infectious Complications in Multiple Myeloma Patients Receiving Various Antitumor Regimens
Authors: Novikova Anna Aleksandrovna , Klyasova G.A. , Gribanova E.O. , Ryzhko V.V. , Tupoleva T.A. , Mendeleeva L.P. , Savchenko V.G.
Published: March 2019

Aim. To study infectious complications and factors attributable to them as reported in multiple myeloma (MM) patients in the framework of state-of-the-art anticancer therapy. Materials & Methods. The study included MM patients who received regimens based on bortezomib, lenalidomide, and bendamustine from January 2013 to August 2018. The regimens including thalidomide, melphalan, and aggressive antitumor treatment constituted the group of “others”. Results. The study enrolled 174 patients (82 men and 92 women with median age of 61 years) with newly diagnosed MM (with median follow-up of 5.6 months). A total of 1362 courses of antitumor treatment were administered: 895 bortezomib (n = 174), 306 lenalidomide (n = 68), and 63 bendamustine (n = 22) regimens. The category of “others” included 98 treatment courses (n = 34). Infectious complications were reported in 129 (74.1 %) MM patients throughout the period of 344 (25.3 %) courses of antitumor treatment. Infection incidence on bortezomib (24.4 %), lenalidomide (20.3 %), and bendamustine (27 %) therapies was similar, and fell clearly below the infection incidence registered on the regimens constituting the group of “others” (48 %; р < 0.01). The most common infectious complications were pneumonias (54.9 %), urinary (24.7 %), and herpesviral infections (22.9 %). Herpesviral infections were predominantly associated with bortezomib treatment (29.8 %; p < 0.05). Significant factors (р < 0.05) associated with infection development were leukopenia, the presence of central venous catheter (CVC), need for blood transfusion, MM progression or relapse. Conclusion. Infection incidence in MM patients receiving bortezomib, lenalidomide, and bendamustine anticancer therapy appeared to be similar, but considerably lower than in patients who received antitumor regimens belonging to category “others”. The prevalent type of infectious complications was pneumonia. Herpesviral infections were most common on bortezomib regimens. Factors related to infection development throughout all therapies were leukopenia, the presence of CVC, need for blood transfusion, MM progression or relapse.
Radioecological assessment of the agricultural lands and products in south-west districts of the Bryansk region contaminated by radionuclides as the result of the Chernobyl NPP accident
Authors: Panov A. V. , Prudnikov P. V. , Titov I. E. , Krechetnikov V. V. , Ratnikov A. N. , Shubina O. A.
Published: March 2019

The aim of this study was to analyze the current radioecological situation in agriculture in five south-west districts of the Bryansk region, which were exposed to the most radiation influence due to the accident at the Chernobyl NPP. Currently, there are 135 collective farms in the observed areas. The total area of agricultural lands was 266.2 thousand hectares. The area of agricultural lands with 137Cs contamination over 37 kBq/m2 was 244.8 thousand hectares in 2018. The area of arable land, hay fields and pastures located in the zone with a 137Cs soil surface activity in a range of 37–185 kBq/m2 is 135.1 thousand hectares, 185–555 kBq/m2– 88.3 thousand hectares, 555-1480 kBq/m2 – 19.8 thousand hectares. At present, only 21.4 thousand hectares (8% of the agricultural lands in the considered areas) don’t exceed contamination levels of 137Cs 37 kBq/m2, and they can be classified as “clean territory”. Analysis of the agricultural products radiation monitoring data from the collective farms of the south-west districts of the Bryansk region showed that the part of feed and crop products exceeded the standards varied from 4 to 15% in 2017-2018. The high content of 137Сs in the feed of several collective farms determined the excess of sanitary and hygienic standards in livestock products from these farms – milk in 4-8% of total samples, beef in 5–8% of total samples. The collective farms located in Krasnogorsky and Novozybkovsky districts of the Bryansk region, with a high risk of exceeding the standards for the content of radionuclides in the agricultural products, was identified. The required volumes of rehabilitation measures in the plant growing and animal husbandry of the south-west districts of the Bryansk region was indicated. It was found that 75 thousand hectares of the total area of agricultural lands need radical improvement and the introduction of higher doses of agromeliorants to produce plant-growing and fodder products corresponding to the legislation standards. To produce milk and beef that comply with sanitary and hygienic standards for livestock products, it is necessary to use ferrocyanide treatment in volumes of 10.5 t/a. It was shown that most radioactively contaminated rural areas need individual programs for the application of rehabilitation technologies. Such programs should provide the population safety and domestic activity.
Síndrome de corea hiperglicemia y ganglios basales
Authors: González Paulina , Ramírez-Botero Catalina , Cadavid Clara Marcela , Aguirre Hernán Darío
Published: March 2019

La diabetes mellitus es una enfermedad de alta prevalencia, así como también lo son sus complicaciones agudas. Una de ellas es el estado hiperosmolar no cetósico que raramente se asocia con alteraciones involuntarias del movimiento. Sin embargo, existe una condición que asocia alteraciones glucémicas con desórdenes del movimiento, denominado síndrome de corea hiperglicemia y ganglios basales, de la cual presentamos un caso y hacemos revisión de la literatura.
Islam and woman
Authors: Adzhigova Aia Magometovna
Published: March 2019

This article describes the basic rules and regulations prescribed in the Quran and shows that the Quran is the main holy book, which contains the basic ideas and principles of the teachings of Muhammad, revered in Islam. Based on primary sources, in particular, relying on the teachings of the Quran, the position of a woman in Islam, her rights and obligations are shown.
Challenges in the Patient With Pulmonary Hypertension and Atrial Septal Defect: Understanding When and How to Close the Defect
Authors: Mullen Mary P.
Published: March 2019

Atrial septal defects (ASDs) are common congenital heart defects in children and adults. Pulmonary arterial hypertension (PAH) is found in subsets of both pediatric and adult patients with atrial defects under varied clinical contexts. The pulmonary hypertension specialist is often faced with questions surrounding timing and method of defect closure, which may have significant impact on procedural and long-term morbidity and survival. This review highlights important differences in management between children and adults with ASDs associated with PAH, highlighting indications for closure, operability, types of closure, and long-term outcomes.
Jedna czy wiele normatywności?
Authors: Piekarski Michał
Published: March 2019

Celem niniejszych rozważań jest zarysowanie nowego podejścia w analizowaniu, czym jest normatywność. Po pierwsze (§1–2) wskazuję na miejsce problemu normatywności we współczesnej filozofii, koncentrując się sporze pomiędzy naturalizmem i antynaturalizmem. Następnie (§3) omawiam tzw. odgórną drogę w badaniu normatywności, którą przeciwstawiam inspirowanej przez współczesną filozofię nauki, drodze oddolnej (§4). W integracji podejścia odgórnego i oddolnego upatruję możliwość takiego badania zjawisk normatywnych, które nie będzie ich redukowało do jednego z rodzajów normatywności (np. moralności).
INNOVATIVE SOLUTIONS OF ADSORPTION CLEANING RECIRCULATING AIR FOR ELECTRIC TESTS OF ELECTRIC PRODUCT TESTS
Authors: Minko V. A. , Kobelev N. S. , Kretova V. M. , Kobelev V. N. , Amelin V. Yu. , Soloviev A. D.
Published: March 2019

The purpose of the study of this work: to provide a scientific justification for the energy-saving device to maintain the normalized parameters of the recirculated air in special “clean” rooms, to derive formulas for calculating the adsorption material during the operation of the installation. The novelty of the constructive solution is protected and confirmed by patents of the Russian Federation for the invention. Methods. The volume of adsorbent determined by this method is placed in a tank with a recirculation loop, which includes: a cleaning unit nozzle, the inner surface of which is spring-loaded with a grid placed on the side of a moving air flow and a grid around the entire outlet section of the expanding nozzle. Spring-loaded mesh, placed on the side of a moving air flow, is made according to the profile of the velocity profile of the moving air flow, which is caused by the manifold speed impact on the adsorbent grains, horizontally arranged layers in order to level the absorbing capacity of silica gel KSM-5 throughout the drying device and use in the system recirculation of the air supplied by the fan leads to a probable entry of the vaporous mass of oil into the stream being cleaned, and the analysis of scientific and technical oh showed no literature data on the nature of such contaminants granular filter material, resulting in the need to study the penetration of the oil by volume adsorbent per cycle electrical testing of electronic devices in a heat chamber. Results. Based on the analysis of well-known foreign and domestic theoretical and experimental studies, there was no development related to vibration effects on the efficiency of adsorption drying of recirculated air for electrical thermal testing of electronic products. An adsorption unit has been developed with a horizontal arrangement of an adsorbing substance for treating air under conditions of vibration effects. Conclusion The installation developed by the authors passed laboratory and industrial tests at the Mayak plant of Kursk and was recommended for implementation as a resource-saving constructive solution protected by patents of the Russian Federation for invention. Keywords: special premises electrical testing of electronic products, recirculation circuit in the chamber for temperature testing - heat chamber, adsorption drying, transparent body of the drying device, oil contamination.
PRINCIPLES OF FORMATION OF A MULTIFUNCTIONAL CENTERS FOR TRAINING EXTREME SPORTS IN KURSK
Authors: Skripkina J. V. , Lalykina J. A.
Published: March 2019

The purpose of this paper is to identify the basic principles of formation of a multifunctional complex for extreme sports. It includes a comparative analysis of extreme sports facilities in Kursk as well as a number of previously studied similar projects and existing buildings by Russian and foreign architects. The authors of the paper propose a sports complex that fits into the existing architecture of the city. New technologies have been introduces to implement the design of such complex objects as a wind tunnel, a deep-water diving pool, a large-span indoor skate hall with seats for spectators and overhead light. All these elements have been taken from the projects of well-known architectural firms, such as eXtreme Architects, White Studio, Moko Architects, as well as other foreign projects of Danish and Norwegian architects. The authors also considered some ideas on the reconstruction of industrial facilities, such as a fan depot or a silo tower, which were converted into multifunctional sports complexes. The social, economic and environmental aspects of designing such an object have been taken into consideration. The authors give the regulatory framework including the fire safety requirements, requirements on building maintenance by limited mobility populations (MH), the impact on the environment. Moreover, the authors mention building regulations, which establish requirements to the equipment, inventory and the space of the whole complex. The article examines the importance of building a multifunctional complex for practicing extreme sports, and also confirms the relevance of such sports in Kursk.
Apolo adentra a clínica junguiana
Authors: Reikdal Marlon
Published: March 2019

Frente ao preconceito pautado no argumento de que o mundo precisa deixar de ser apolíneo ou que o analista junguiano deve afastar-se de Apolo, este trabalho reflete sobre a real necessidade de interdição de Apolo na clínica. Para isso, resgataram-se as diferentes abordagens que caracterizam o deus da mitologia grega como figura complexa e multifacetada. Sua presença no consultório suscitou o estudo da transferência e da contratransferência. Como ferramenta de análise, extraiu-se das características de Apolo o que parecia mais marcante na possível interferência à atuação clínica: o poder e o distanciamento emocional. Em forma de julgamento, referindo-se à condenação do logos no meio junguiano, este trabalho se transformou numa carta em defesa de Apolo e de todos os deuses, sem a necessidade do sacrificium intellectus. O temenos analítico revela-se como arena de vozes, palco do politeísmo, onde todos os deuses podem e devem se presentificar sem qualquer interdição a um ou outro para que o analista cumpra com o  seu papel.
Exploring the Challenges of Implementing a Web-Based Telemonitoring Strategy for Teenagers With Inflammatory Bowel Disease: Empirical Case Study (Preprint)
Authors: Dijkstra Alie , Heida Anke , van Rheenen Patrick Ferry
Published: March 2019

BACKGROUND

We designed a telemonitoring strategy for teenagers with inflammatory bowel disease to prevent an anticipated disease flare and avert unplanned office visits and day care procedures. The strategy was evaluated in a randomized controlled trial that involved 11 Dutch pediatric gastroenterology centers, each using repeated symptom scores and stool calprotectin measurements. In the telemonitoring arm of the trial, teenagers (n=84) as well as their health providers were alerted to out-of-range results, and suggestions for change in therapy were offered. We demonstrated that the technology was a safe and cost saving alternative to health checks by the specialist at fixed intervals.

OBJECTIVE

The aim of this study was to evaluate whether we could move our telemonitoring strategy from a demonstration project to one that is sustained within existing sites.

METHODS

In this empirical case study, we used the nonadoption, abandonment, scale-up, spread, and sustainability (NASSS) framework to explore the challenges to implementing our strategy. The framework distinguishes 7 domains: (1) the illness, (2) the technology, (3) the value proposition, (4) the adopter system, (5) the organization, (6) the societal system, and (7) the time dimension. We summarized the challenges across all 7 domains and classified them as simple (+++), complicated (++), or complex (+). Technologies in which multiple domains are complicated have proven difficult to implement, whereas those with multiple complex domains may not even become mainstreamed.

RESULTS

The technology that we used and the linked program (IBD-live) allowed us to select and target the teenagers who were most likely to benefit from a face-to-face encounter with their specialist (+++). The value proposition of the technology was clear, with a distinct benefit for patients and an affordable service model, but health providers had plausible personal reasons to resist (double data entry, ++). The organization was not yet ready for the innovation, as it requires a shift to new ways of working (+). We had no concerns about reimbursement, as Dutch health insurers agreed that screen-to-screen consultations will be reimbursed at a rate equivalent to face-to-face consultations (+++). Finally, the technology was considered easy to adapt and evolve over time to meet the needs of its users (+++).

CONCLUSIONS

The challenges to be addressed are merely complicated (++) rather than complex (+), which means that our program may be difficult but not impossible to sustain within existing sites. After integrating the technology and its use with local workflows first, we believe that our telemonitoring strategy will be ready for sustained adoption. In contrast with what we did ourselves, we recommend others to use the NASSS framework prospectively and in real time to predict and explore the challenges to implementing new technologies.
Exploring the Extent of the Hikikomori Phenomenon on Twitter: Mixed Methods Study of Western Language Tweets (Preprint)
Authors: Pereira-Sanchez Victor , Alvarez-Mon Miguel Angel , Asunsolo del Barco Angel , Alvarez-Mon Melchor , Teo Alan
Published: March 2019

BACKGROUND

Hikikomori is a severe form of social withdrawal, originally described in Japan but recently reported in other countries. Debate exists as to what extent hikikomori is viewed as a problem outside of the Japanese context.

OBJECTIVE

We aimed to explore perceptions about hikikomori outside Japan by analyzing Western language content from the popular social media platform, Twitter.

METHODS

We conducted a mixed methods analysis of all publicly available tweets using the hashtag #hikikomori between February 1 and August 16, 2018, in 5 Western languages (Catalan, English, French, Italian, and Spanish). Tweets were first classified as to whether they described hikikomori as a problem or a nonproblematic phenomenon. Tweets regarding hikikomori as a problem were then subclassified in terms of the type of problem (medical, social, or anecdotal) they referred to, and we marked if they referenced scientific publications or the presence of hikikomori in countries other than Japan. We also examined measures of interest in content related to hikikomori, including retweets, likes, and associated hashtags.

RESULTS

A total of 1042 tweets used #hikikomori, and 656 (62.3%) were included in the content analysis. Most of the included tweets were written in English (44.20%) and Italian (34.16%), and a majority (56.70%) discussed hikikomori as a problem. Tweets referencing scientific publications (3.96%) and hikikomori as present in countries other than Japan (13.57%) were less common. Tweets mentioning hikikomori outside Japan were statistically more likely to be retweeted (P=.01) and liked (P=.01) than those not mentioning it, whereas tweets with explicit scientific references were statistically more retweeted (P=.01) but not liked (P=.10) than those without that reference. Retweet and like figures were not statistically significantly different among other categories and subcategories. The most associated hashtags included references to Japan, mental health, and the youth.

CONCLUSIONS

Hikikomori is a repeated word in non-Japanese Western languages on Twitter, suggesting the presence of hikikomori in countries outside Japan. Most tweets treat hikikomori as a problem, but the ways they post about it are highly heterogeneous.
Praktik pemberian makan terhadap kejadian kurus pada anak baduta
Authors: Puspitasari Fithia Dyah , Sitaresmi Mei Neni , Susetyowati Susetyowati , Barida Iram , Handayani Kartika
Published: March 2019

Background: Wasting is an acute malnutrition form that interrupts immune function, prolong duration of infection and in the end increase mortality risk of children. It is not clear yet which risk factor leading to wasting, simply because wasting-suspected risk factors were also involved in another kind of malnutrition such as stunting and underweight.Objective: To determine whether infant and young child feeding practices is risk factor for wasting in under two year children.Method: This research was mix method research which used matching case control design for quantitative research and focus group discussion to gather information in qualitative research. Case were wasting children age 3-23 months old (z-score WHZ <-2 SD) while control were non-wasting children age 3-23 months old (z-score WHZ ≥-2 SD). This research involved 106 under-two years old children and 14 nutritionist from 14 community health center which randomly chosen. Control group was matched by age and socio economic to case group.Results: Case group had more proportion of inappropriate feeding practices (26.41%% vs 20.75%). More than half respondent failed to meet Indonesian recommended dietary allowance for energy (57.55%). Inappropriate infant and young child feeding practice significantly did not increased risk of wasting in under two children at Yogyakarta (OR=1.4; 95% CI:0.62-3.36; p=0.523). Nutritionist from community health center focused in consultation and counseling in effort to increase infant and young child feeding practice.Conclusion: Feeding practices in under-two children in Yogyakarta was already good. Infant and young child feeding practice was not risk factor for wasting in under two years old children at Yogyakarta.
Assessment of Informal Settlements Growth in Greater Karu Urban Area (GKUA) Nasarawa State, Nigeria
Authors: Rikko Laraba S. , Dung-Gwom John. Y. , Habila Sunday K.
Published: March 2019

The proliferation of informal settlements in developing countries have become a major concern to governments and professionals in the built environment in recent years. This paper assessed informal human settlements in a rapidly urbanizing and growing urban area; the Greater Karu Urban Area (GKUA) in Nasarawa State of Nigeria. Information for the paper were obtained through the administration of a questionnaire on the residents and from published and official records. Data was collected from 4 out a 17 identified informal settlements; Mararaba, Masaka, New Nyanya and Kuchikau in GKUA. Questionnaires were administered to 10% (253) households’ randomly selected based on their availability and willingness to participate in the study. From 241 (95.4%) questionnaires that were returned, two types of informal settlements were identified: inner core (traditional slums) and the peri-urban informal/unplanned settlements/slums. The inner core slums showed very severe challenges pertaining to minimal and inadequate social amenities and infrastructure, poor sanitation, narrow winding road networks while the absence of social services and infrastructure, unplanned and uncontrolled development, and substandard housing of mixed quality characterised peri-urban slums. Residents perceived that internal and external drivers contributed to the rapid growth of informal settlements in GKUA. A Comprehensive and holistic spatial vision of the area that could promote and sustain physical, social, economic and environmental planning policies in a coordinated manner is urgently needed.
Introducción al estudio de los hongos superiores II
Authors: Lazo Waldo
Published: March 2019

Se presenta descripciones e ilustraciones de los géneros de hongos superiores más comunes de Chile central, además de las claves para la identificación de diversas especies pertenecientes a estos géneros.
Hongos fitopatógenos asociados a la enfermedad de marchitez vascular y muerte regresiva en plantaciones de Tectona grandis L.f. (teca) en el Trópico Húmedo Ecuatoriano
Authors: Belezaca Pinargote Carlos , Solano-Apuntes Edison , Lopez-Tobar Rolando , Baque-Mite Renato , Ávila-Loor Adrián , Cóndor-Jiménez María , Bohórquez-Barros Tito , Dueñas-Alvarado Darío
Published: March 2019

Plantaciones de teca (Tectona grandis L. f.) en Ecuador están siendo afectadas por una compleja enfermedad de marchites vascular y muerte regresiva, con características epidémicas, sin que hasta el momento se conozca el o los agentes causales. Se planteó describir la sintomatología de la enfermedad e identificar los hongos fitopatógenos asociados a árboles enfermos en el Trópico Húmedo Ecuatoriano. Se seleccionaron tres plantaciones de 2, 5 y 7 años de edad, en cada una se delimitó tres parcelas de 500 m2. Se realizó la descripción sintomatológica, evaluó la incidencia y severidad de la enfermedad empleando una escala de cinco categorías. Por parcela se diseccionaron tres árboles, cuyos tejidos se llevaron al laboratorio, donde se emplearon tres estrategias metodológicas (cámara húmeda, sanduches de zanahoria, y medio de cultivo papa-dextrosa-agar; PDA) para estimular la expresión de los fitopatógenos. En árboles enfermos se detectó clorosis, pérdida de turgencia, ápices de crecimiento secos, emisión de brotes epicormicos en el fuste, y marchitez fulminante. Se aisló e identificó Ceratocystis fimbriata Ellis & Halst., y Fusarium sp. de forma consecutiva con las tres estrategias metodológicas empleadas. La incidencia de la enfermedad fue del 16.6%, 15.2%, y 11.6% para las plantaciones de 2, 5 y 7 años, respectivamente. Los árboles enfermos en la plantación de 2 años se encontraron en las escalas 2, 4 y 5, mientras que en plantaciones de 5 y 7 años se ubicaron en las escalas 2, 3 y 5 de progreso de la enfermedad.
ERECTILE DYSFUNCTION IN MEN WITH TYPE 2 DIABETES: IS IT ASSOCIATED WITH POOR GLYCEMIC CONTROL?
Authors: Almigbal Turky H
Published: March 2019

Background and Objective

Erectile dysfunction (ED) is a widespread clinical issue with many new cases diagnosed every year. The prevalence of ED in men with type 2 diabetes millitus (T2DM) ranges from 35–90%, depending on patient characteristics and the method used to diagnose it. There is inconsistent evidence about the association between ED and the degree of glycemic control in men with T2DM. Our main objective was to investigate the association between ED in patients with T2DM and poor glycemic control, as well as other factors.

Material and Methods

This is a cross-sectional study based on a self-administrated questionnaire. The study was conducted from July to September 2017at King Saud University-Medical City, Riyadh, Saudi Arabia. Participants in this study were older than 18-years-old. The data from the questionnaire were analyzed using the SPSS program (Armonk, NY, USA).

Results

The prevalence of ED is 80.5%, while a severe degree is seen at 33%. There were several factors significantly associated with it, including age (p-value = 0.01), education level (p-value = 0.01), monthly income (p-value = 0.01), occupation status (p-value = 0.01), duration of diabetes (p -value = 0.01), type of treatment of diabetes ( p -value = 0.01), and diabetes status (p -value = 0.01). Increasing age (above 60 years of age), duration, and uncontrolled diabetes were associated with a high risk of developing ED.

Conclusion

ED was highly prevalent in patients with T2DM and poor glycemic control, as well as advanced age and duration of diabetes: each was associated with increased risk of ED.
Modeling Movement of Gas-Static Bearings
Authors: Kodnyanko V. A.
Published: March 2019

The competitiveness of gas-static sliding bearings, which are assemblies of cutting-edge machines, in particular, precision metal-cutting machines, largely depends on their creation rapidity, which is determined by their mobility of modeling and quality of theoretical study for the later use in designing constructions. The objective is to develop a computer-aided mobile modeling technology for designing the gas-static bearings, which enables quick calculation and study of their static characteristics, quality criteria for their dynamics, and drawing-up recommendations for rapid designing of bearings to ensure performance characteristics and appropriate dynamics quality of designs through automation of procedures, their mathematical modeling, and theoretical study. As a result, there has been developed a technology concept for modeling of gas-static bearings and numerical methods, which allow us to find a solution for exploring tasks with a desirable accuracy. Based on the approximate and proposed numerical methods, the developed modeling technology rapidity was studied, and high comparative efficiency of this technology was found. Practical relevance of technology lies in significant acceleration of modeling processes, calculation and study of static and dynamic characteristics of gas-static bearings that is provided by application of developed methods, algorithms, and modeling technology. There are also reducing the complexity of research processes, and the capability for quick learning of complex bearing structures rapid exploration of which is hard or inconceivable using the traditional “manual” technology.
The Choice of Evaluation Vibration Car Security
Authors: Zheglov L. F. , Fominykh A. B.
Published: March 2019

In the presented material of the article the debatable question - a question of a choice of the field of mathematical modeling of system of vibration isolation of the car is considered. It is known that such a problem can be solved in the frequency and time domain. Since the primary vibration isolation system of the car has non-linear elements, the question arises: how does the solution of the linearized dynamic system in the frequency domain correspond to the data of calculations of the accepted indicators in the time domain? The problem is solved with a random kinematic perturbation from the road surface. Therefore, when working in the time domain, it is necessary to pre-select the method of statistical linearization from the known in practice design of automatic control systems.

Four methods of statistical linearization, using which calculations were carried out in the frequency domain, are considered. For a similar dynamic system with its initial and statistically linearized nonlinear elements, calculations were carried out in the time domain. It is shown that the first method of statistical linearization is the most adaptive, according to the amplitude-frequency characteristics of the system. Such calculations were carried out for two surfaces corresponding to the cobblestone and dirt road at different speeds of the car.

The analysis of the calculated amplitude-frequency characteristics was carried out for the "resonant" speed of motion, at which the greatest manifestation of the system nonlinearity takes place. When driving in this mode, the system significantly increases the probability of losing contact with the tire support surface. This violates the safety of the vehicle and the system is out of the vibration safety analysis area. Especially this phenomenon is observed when driving on a dirt road at a "resonant" speed. The final results of the calculations are separate-frequency and integral parameters. The latter do not give priority in the selection of the area of calculation, provided the safety of the vehicle.

Thus, it can be concluded that the adequacy of the calculations in the frequency and time domain under really specified conditions of the vehicle on the corresponding road surface. However, testing of the problem to be solved, for example, by the eigenfrequency vector of a conservative system, is advisable to be carried out in the frequency domain.
Caracterização da dieta de Melanosuchus niger (Spix, 1825) e Caiman crocodilus (Linnaeus, 1758) na Resex Lago do Cuniã, Rondônia
Authors: Da Costa Igor David , Dos Santos Nunes Natalia Neto
Published: March 2019

O objetivo deste estudo foi caracterizar a dieta de indivíduos machos de Melanosuchus niger e Caiman crocodilus em um lago da Reserva Extrativista do Lago do Cuniã, Rondônia. Foram coletados intestinos dos animais em novembro/2016, estação chuvosa, fornecidos pela Cooperativa local (COOPCuniã). As cavidades abdominais dos jacarés foram abertas e seu estômago foi retirado e armazenado em álcool a 70%, e os alimentos foram analisados. Foram analisados 82 estômagos, 42 de M. niger e 40 de C. crocodilus. Alimentos como fragmentos de aves, anfíbios, crustáceos, insetos e material vegetal foram ingeridos pelas espécies estudadas. No entanto, os itens mais representativos na dieta de M. niger e C. crocodilus foram peixes da ordem Characifomes e Siluriformes sem importância comercial.
VII Simposio Argentino del Paleozoico Superior - VII SAPS - Libro de Resúmenes
Authors: Taboada Arturo César
Published: March 2019

VII Simposio Argentino del Paleozoico Superior - VII SAPS - Libro de ResúmenesEsquel, 26, 27 y 28 de Marzo de 2018Organizador:  centro de investigación Esquel de montaña y estepa patagonica (ciemep).Coordinador:  Dr. Arturo C. TaboadaCentro de Investigación Esquel de Montaña y Estepa Patagónica (CIEMEP),taboadaart@gmail.comSecretaria:  Analia RamonCentro de Investigación Esquel de Montaña y Estepa Patagónica (CIEMEP), secretariaciemep@comahue-conicet.gob.arComité EditorDra. María Alejandra Pagani (MEF) ? CoordinadoraDra. Patricia Ciccioli (IGEBA-UBA)Dr. Ignacio Escapa (MEF)Dra. Margaret Fraiser (UWM)Dra. Silvana Geuna (IGEBA-UBA)Dra. Jacqueline Peixoto Neves (UTFPR) Comité científico Dra. Silvia Césari (MACN)Dr. Carlos Cingolani (UNLP)Dr. Rubén Cúneo (MEF)Dr. Oscar López Gamundi (P1CONSULTANTS) Avales InstitucionalesCentro de Investigación Esquel de Montaña y Estepa Patagónica (CONICET-UNPSJB) D N° 04/17Secretaría de Ciencia y Técnica de la Provincia del ChubutAsociación Paleontológica ArgentinaAsociación Latinoamericana de Paleobotánica y PalinologíaMuseo Eugidio Feruglio (MEF)Municipalidad de Esquel OM 121/17
Does Financial Flexibility Matter for Firm’s Finance Policy? Evidence from Swedish High -Tech Firms: Case Study of Ericsson
Authors: Al-Shakrchyai Eatessam , Alnassar Walaa Ismael
Published: March 2019

This paper explores why high-tech firms with high credit quality are more likely to have external finance, and if the securing funding is related to financial flexibility.  Many earlier studies have shown that it is valuable for firms to choose financial policies that keep financial flexibility to respond to negative shocks in the form of unexpected periods of insufficient resources. However, the complexity and unpredictability in high?tech business make the flexibility in finance more valuable to face an increasingly unpredictable environment and to grow into a hugely profitable. Degree of financial flexibility has estimated in three different models based on leverage to investigate whether the flexibility degree affects the company’s ability and to find out the driving factor in financial flexibility indicators. By using financial data from annual reports of the Swedish multinational networking and telecommunications company “Ericson” during the period 2007 to 2016, the results provide evidence that the high-tech company has a high access to capital markets due to its low leverage and keeping an equity ratio over 45% which supporting the hypothesis that financial flexibility matter and has influence on the firm's ability to get access and restructure its financing.
The progress of science from a computational point of view: the drive towards ever higher solvability
Authors: Marciszewski Witold
Published: March 2019

This essay’s content is rendered by the titles of the successive sections. 1. Effective solvability versus intuitive solvability. — 2. Decidability, i.e. effective solvability, in predicate logic. The speedup phenomenon — 3. Contributions of the second-order logic to the problems of solvability — 4. The infinite progress of science in the light of Turing’s idea of the oracle. The term “oracle” is a technical counterpart of the notion of mathematical intuition.

A more detailed summary can be obtained through juxtaposing the textboxes labelled with letters A...F. Conclusion: in the progress of science an essential role is played by the feedback between intellectual intuitions (intuitive solvability) and algorithmic procedures (effective solvability).
Deanthropomorphized Pancomputationalism and the Concept of Computing
Authors: Polak Paweł , Krzanowski Roman
Published: March 2019

Pancomputationalism is quite a wide-ranging concept, but most of its variants, either implicitly or explicitly, rely on Turing’s conceptualizations of a computer and computing, which are obvious anthropomorphisms. This paper questions the concept of pancomputationalism based on Turing computing and asks what concept of computation can be used to avoid the constrains of anthropomorphisations.
Direct Blue 2 diazo-boyarmaddesinin sulu çözeltiden P(HEMA) nanopartiküller ile uzaklaştırılması
Authors: GÖÇENOĞLU SARIKAYA Aslı
Published: March 2019

Bu çalışmada, Direct Blue 2 (DB2) diazo-boyar maddesinin poli(Hidroksietil metakrilat) [P(HEMA)] nanopartikülleri ile sulu çözeltiden giderimi çalışılmıştır.  Adsorpsiyona ortam pH’ının, sıcaklığın, başlangıç boya derişiminin ve temas süresinin etkileri incelenmiştir.  Optimum koşullar altında, 50 mg/mL başlangıç boya derişimi ve 2 mg polimer kullanılarak % 89.1 giderim elde edilmiştir.  Adsorpsiyon mekanizmasının anlaşılabilmesi için Langmuir, Freundlich ve Sips (Langmuir-Freundlich) izoterm sabitleri hesaplanmıştır.  Elde edilen verilere göre adsorpsiyonun Langmuir izoterm modeline uygun olduğu (R2: 0.993, Qmax: 27.1 mg/g) rapor edilmiştir.  Adsorpsiyon öncesi ve sonrası boya derişimleri UV-Vis spektrofotometresinde ölçülmüş, adsorpsiyon öncesi ve sonrası polimer FTIR ve SEM ile karakterize edilmiştir. 
ASPECTOS TÉCNOLÓGICOS E PERSPECTIVAS DE DESENVOLVIMENTO DO CULTIVO DE TILÁPIA NO BRASIL
Authors: Igarashi Marco Antonio
Published: March 2019

RESUMO: O presente estudo analisa a participação da tilápia no desenvolvimento da aquicultura no Brasil, além da situação do cultivo, produção, prospectos, avaliar a evolução da produção e tecnologia. Os resultados demonstram que a tilápia tem oferecido uma valiosa contribuição, notadamente no que diz respeito ao aumento da oferta de alimento proteico de origem animal. Portanto o consumo de tilápias continuará a crescer mas o aumento da produção doméstica poderá pressionar para baixo os preços, fazendo as tilápias mais competitivas com outros produtos de água doce e marinho. Conclui-se que com adequado investimento, manejo e conservação dos recursos ambientais, a tilapicultura poderá tornar-se uma atividade da maior importância para o crescimento  socio-econômico do Brasil. Com tremendo recurso no Brasil para o cultivo de tilápias uma das expectativas é a de que o Brasil produzirá uma significante quantidade de tilápia para a exportação em um futuro próximo e constituir uma importante atividade socio-econômica.
BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV
Authors: Schaeffner Marisa , Mrozek-Gorska Paulina , Buschle Alexander , Woellmer Anne , Tagawa Takanobu , Cernilogar Filippo M. , Schotta Gunnar , Krietenstein Nils , Lieleg Corinna , Korber Philipp , Hammerschmidt Wolfgang
Published: March 2019

A hallmark of EBV infections is its latent phase, when all viral lytic genes are repressed. Repression results from a high nucleosome occupancy and epigenetic silencing by cellular factors such as the Polycomb repressive complex 2 (PRC2) and DNA methyltransferases that, respectively, introduce repressive histone marks and DNA methylation. The viral transcription factor BZLF1 acts as a molecular switch to induce transition from the latent to the lytic or productive phase of EBV’s life cycle. It is unknown how BZLF1 can bind to the epigenetically silenced viral DNA and whether it directly reactivates the viral genome through chromatin remodeling. We addressed these fundamental questions and found that BZLF1 binds to nucleosomal DNA motifs both in vivo and in vitro. BZLF1 co-precipitates with cellular chromatin remodeler ATPases, and the knock-down of one of them, INO80, impaired lytic reactivation and virus synthesis. In Assay for Transposase-Accessible Chromatin-seq experiments, non-accessible chromatin opens up locally when BZLF1 binds to its cognate sequence motifs in viral DNA. We conclude that BZLF1 reactivates the EBV genome by directly binding to silenced chromatin and recruiting cellular chromatin-remodeling enzymes, which implement a permissive state for lytic viral transcription. BZLF1 shares this mode of action with a limited number of cellular pioneer factors, which are instrumental in transcriptional activation, differentiation, and reprogramming in all eukaryotic cells.
Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesis
Authors: Dori Martina , Haj Abdullah Alieh Leila , Cavalli Daniel , Massalini Simone , Lesche Mathias , Dahl Andreas , Calegari Federico
Published: March 2019

Circular (circ) RNAs have recently emerged as a novel class of transcripts whose identification and function remain elusive. Among many tissues and species, the mammalian brain is the organ in which circRNAs are more abundant and first evidence of their functional significance started to emerge. Yet, even within this well-studied organ, annotation of circRNAs remains fragmentary, their sequence is unknown, and their expression in specific cell types was never investigated. Overcoming these limitations, here we provide the first comprehensive identification of circRNAs and assessment of their expression patterns in proliferating neural stem cells, neurogenic progenitors, and newborn neurons of the developing mouse cortex. Extending the current knowledge about the diversity of this class of transcripts by the identification of nearly 4,000 new circRNAs, our study is the first to provide the full sequence information and expression patterns of circRNAs in cell types representing the lineage of neurogenic commitment. We further exploited our data by evaluating the coding potential, evolutionary conservation, and biogenesis of circRNAs that we found to arise from a specific subclass of linear mRNAs. Our study provides the arising field of circRNA biology with a powerful new resource to address the complexity and potential biological significance of this new class of transcripts.
Trombüs aspirasyonuna sekonder gelişen bir komplikasyon: Yaygın sol sistem trombüsü ve başarılı yönetimi
Authors: Örsçelik Özcan , Özcan Mert Koray , Sürmeli Ali Orçun , Özkan Buğra , Özcan İsmail Türkay , Çelik Ahmet , Akkuş Mehmet Necdet
Published: March 2019

Akut koroner sendromlarda (miyokard infarktüsü, kararsız
angina) intrakoroner trombüs görülme oranı yüksektir. Miyokard infaktüsü ile
gelen hastalarda intrakoroner trombüs mevcudiyeti güncel müdahale tekniklerine
rağmen işlem başarısını düşürmekte ve çeşitli komplikasyonlara neden
olmaktadır. Bizim vakamızda 49 yaşında erkek hastada gelişen komplikasyonlar ve
yönetimi sunulmuştur. ST elevasyonlu miyokard infarktüsü ile gelen hastanın son
ön inen koroner arterde trombüsün aspirasyonu sonrası tüm sol sistemde yaygın
trombüs gözlemlendi. İntrakoroner heparin ve tirofiban sonrasında trombüs
geriledi ve direkt stent implantasyonu ile kompikasyon başarılı bir şekilde
yönetildi. Son kılavuzlarda da gösterildiği üzere trombüs aspirasyonu, yoğun
koroner arter trombüsü olması durumunda mortaliteyi istatistiksel olarak
anlamlı olmasa da azalttığı gösterilmiş ancak koroner arter trombüs aspirasyonu
rutin olarak önerilmemektedir.