bluuebunny/crossref_metadata_2025 huggingface dataset:
High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer
Authors: Jansson Keith H. , Tucker John B. , Stahl Lauren E. , Simmons John K. , Fuller Caitlyn , Beshiri Michael L. , Agarwal Supreet , Fang Lei , Hynes Paul G. , Alilin Aian Neil , Lake Ross , Abbey Yasmine C. , Cawley Jacob , Tice Caitlin M. , Yin JuanJuan , McKnight Crystal , Klummp-Thomas Carleen , Zhang Xiaohu , Guha Rajarshi , Hoover Shelley , Simpson R. Mark , Nguyen Holly M. , Corey Eva , Thomas Craig J. , Proia David A. , Kelly Kathleen
Published: November 2018

The development of new treatments for castrate resistant prostate cancer (CRPC) must address such challenges as intrinsic tumor heterogeneity and phenotypic plasticity. Combined PTEN/TP53 alterations represent a major genotype of CRPC (25–30%) and are associated with poor outcomes. Using tumor-derived, castration-resistant Pten/Tp53 null luminal prostate cells for comprehensive, high-throughput, mechanism-based screening, we identified several vulnerabilities among >1900 compounds, including inhibitors of: PI3K/AKT/mTOR, the proteasome, the cell cycle, heat shock proteins, DNA repair, NFκB, MAPK, and epigenetic modifiers. HSP90 inhibitors were one of the most active compound classes in the screen and have clinical potential for use in drug combinations to enhance efficacy and delay the development of resistance. To inform future design of rational drug combinations, we tested ganetespib, a potent second-generation HSP90 inhibitor, as a single agent in multiple CRPC genotypes and phenotypes. Ganetespib decreased growth of endogenous Pten/Tp53 null tumors, confirming therapeutic activity in situ. Fifteen human CRPC LuCaP PDX-derived organoid models were assayed for responses to 110 drugs, and HSP90 inhibitors (ganetespib and onalespib) were among the select group of drugs (<10%) that demonstrated broad activity (>75% of models) at high potency (IC50 <1 µM). Ganetespib inhibits multiple targets, including AR and PI3K pathways, which regulate mutually compensatory growth and survival signals in some forms of CRPC. Combined with castration, ganetespib displayed deeper PDX tumor regressions and delayed castration resistance relative to either monotherapy. In all, comprehensive data from near-patient models presents novel contexts for HSP90 inhibition in multiple CRPC genotypes and phenotypes, expands upon HSP90 inhibitors as simultaneous inhibitors of oncogenic signaling and resistance mechanisms, and suggests utility for combined HSP90/AR inhibition in CRPC.
Defining Coronary Flow Patterns: Comprehensive Automation of Transthoracic Doppler Coronary Blood Flow
Authors: Sunyecz Ian L. , McCallinhart Patricia E. , Patel Kishan U. , McDermott Michael R. , Trask Aaron J.
Published: November 2018

The coronary microcirculation (CM) plays a critical role in the regulation of blood flow and nutrient exchange to support the viability of the heart. In many disease states, the CM becomes structurally and functionally impaired, and transthoracic Doppler echocardiography can be used as a non-invasive surrogate to assess CM disease. Analysis of Doppler echocardiography is prone to user bias and can be laborious, especially if additional parameters are collected. We hypothesized that we could develop a MATLAB algorithm to automatically analyze clinically-relevant and non-traditional parameters from murine PW Doppler coronary flow patterns that would reduce intra- and inter-operator bias, and analysis time. Our results show a significant reduction in intra- and inter-observer variability as well as a 30 fold decrease in analysis time with the automated program vs. manual analysis. Finally, we demonstrated good agreement between automated and manual analysis for clinically-relevant parameters under baseline and hyperemic conditions. Resulting coronary flow velocity reserve calculations were also found to be in good agreement. We present a MATLAB algorithm that is user friendly and robust in defining and measuring Doppler coronary flow pattern parameters for more efficient and potentially more insightful analysis assessed via Doppler echocardiography.
Author Correction: Regulatory role of G9a and LSD1 in the Transcription of Olfactory Receptors during Leukaemia Cell Differentiation
Authors: Jung Hyeonsoo , Chae Yun-Cheol , Kim Ji-Young , Jeong Oh-Seok , Kook Hoon , Seo Sang-Beom
Published: November 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Author Correction: Genomic amplification upregulates estrogen-related receptor alpha and its depletion inhibits oral squamous cell carcinoma tumors in vivo
Authors: Tiwari Ankana , Swamy Shivananda , Gopinath Kodaganur S. , Kumar Arun
Published: November 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Publisher Correction: An improved method of crafting a multi-electrode spiral cuff for the selective stimulation of peripheral nerves
Authors: Rozman Janez , Pečlin Polona , Ribarič Samo , Godec Matjaž , Burja Jaka
Published: November 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Big bottlenecks in cardiovascular tissue engineering
Authors: Huang Ngan F. , Serpooshan Vahid , Morris Viola B. , Sayed Nazish , Pardon Gaspard , Abilez Oscar J. , Nakayama Karina H. , Pruitt Beth L. , Wu Sean M. , Yoon Young-sup , Zhang Jianyi , Wu Joseph C.
Published: November 2018

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.
Confocal laser scanning microscopy for rapid optical characterization of graphene
Authors: Panchal Vishal , Yang Yanfei , Cheng Guangjun , Hu Jiuning , Kruskopf Mattias , Liu Chieh-I. , Rigosi Albert F. , Melios Christos , Hight Walker Angela R. , Newell David B. , Kazakova Olga , Elmquist Randolph E.
Published: November 2018

Two-dimensional (2D) materials such as graphene have become the focus of extensive research efforts in condensed matter physics. They provide opportunities for both fundamental research and applications across a wide range of industries. Ideally, characterization of graphene requires non-invasive techniques with single-atomic-layer thickness resolution and nanometer lateral resolution. Moreover, commercial application of graphene requires fast and large-area scanning capability. We demonstrate the optimized balance of image resolution and acquisition time of non-invasive confocal laser scanning microscopy (CLSM), rendering it an indispensable tool for rapid analysis of mass-produced graphene. It is powerful for analysis of 1–5 layers of exfoliated graphene on Si/SiO2, and allows us to distinguish the interfacial layer and 1–3 layers of epitaxial graphene on SiC substrates. Furthermore, CLSM shows excellent correlation with conventional optical microscopy, atomic force microscopy, Kelvin probe force microscopy, conductive atomic force microscopy, scanning electron microscopy and Raman mapping.
Emergence of traveling waves in linear arrays of electromechanical oscillators
Authors: Dou Yong , Pandey Shashank , Cartier Charles A. , Miller Olivia , Bishop Kyle J. M.
Published: November 2018

Traveling waves of mechanical actuation provide a versatile strategy for locomotion and transport in both natural and engineered systems across many scales. These rhythmic motor patterns are often orchestrated by systems of coupled oscillators such as beating cilia or firing neurons. Here, we show that similar motions can be realized within linear arrays of conductive particles that oscillate between biased electrodes through cycles of contact charging and electrostatic actuation. The repulsive interactions among the particles along with spatial gradients in their natural frequencies lead to phase-locked states characterized by gradients in the oscillation phase. The frequency and wavelength of these traveling waves can be specified independently by varying the applied voltage and the electrode separation. We demonstrate how traveling wave synchronization can enable the directed transport of material cargo. Our results suggest that simple energy inputs can coordinate complex motions with opportunities for soft robotics and colloidal machines.
Review: a comprehensive summary of a decade development of the recombinase polymerase amplification
Authors: Li Jia , Macdonald Joanne , von Stetten Felix
Published: November 2018

RPA is a versatile complement or replacement of PCR, and now is stepping into practice.
Considerations for uranium isotope ratio analysis by atmospheric pressure ionization mass spectrometry
Authors: Forbes Thomas P. , Szakal Christopher
Published: November 2018

Uranium isotope ratio measurements from discrete trace sample injections were investigated with an ultra-high-resolution hybrid quadrupole time-of-flight mass spectrometer.
A separation voltage polarity switching method for higher sample loading capacity and better separation resolution in transient capillary isotachophoresis separation
Authors: Wu Huanming , Yi Lian , Wojcik Roza , Shi Tujin , Tang Keqi
Published: November 2018

Higher sample loading capacity and better separation resolution achieved by applying a voltage polarity switching method in transient capillary isotachophoresis separation.
A rolling circle amplification-assisted DNA walker triggered by multiple DNAzyme cores for highly sensitive electrochemical biosensing
Authors: Wang Sina , Ji Yuhang , Fu Haomin , Ju Huangxian , Lei Jianping
Published: November 2018

A DNA walker triggered by multiple DNAzyme cores was constructed with the assistance of rolling circle amplification for electrochemical biosensing.
A mitochondria-targetable colorimetric and far-red fluorescent probe for the sensitive detection of carbon monoxide in living cells
Authors: Wang Zuokai , Zhao Ziyang , Wang Ruikang , Yuan Ruifang , Liu Caiyun , Duan Qingxia , Zhu Weiwei , Li Xiuyun , Zhu Baocun
Published: November 2018

A simple colorimetric and far-red fluorescent probe was developed for the first time to visualize the gasotransmitter carbon monoxide in subcellular mitochondria.
A nanozyme tag enabled chemiluminescence imaging immunoassay for multiplexed cytokine monitoring
Authors: Zhong Yihong , Tang Xiao , Li Juan , Lan Qingchun , Min Lingfeng , Ren Chuanli , Hu Xiaoya , Torrente-Rodríguez Rebeca M. , Gao Wei , Yang Zhanjun
Published: November 2018

We propose a new concept of a chemiluminescence imaging nanozyme immunoassay (CINIA), in which nanozymes are exploited as catalytic tags for simultaneous and high-throughput multiplex detection of cytokines.
Palladium catalyzed selective arylation of o-carboranes via B(4)–H activation: amide induced regioselectivity reversal
Authors: Xu Tao-Tao , Cao Ke , Zhang Cai-Yan , Wu Ji , Jiang Linhai , Yang Junxiao
Published: November 2018

Amide induced regioselectivity reversal for selective B(4) arylation of o-carboranes.
Hydride transfer initiated ring expansion of pyrrolidines toward highly functionalized tetrahydro-1-benzazepines
Authors: Wang Shuai , An Xiao-De , Li Shuai-Shuai , Liu Xicheng , Liu Qing , Xiao Jian
Published: November 2018

The first example of ring expansion from a five-membered nitrogen-containing ring to a seven-membered heterocyclic ring has been developed.
Reversible redox inter-conversion of biologically active NAD+/NADH derivatives bound to a gold electrode: ToF-SIMS evidence
Authors: Qian Ruo-Can , Zhao Li-Jun , Lv Jian , Hua Xin , Long Yi-Tao
Published: November 2018

The electrochemical reversible redox of NAD+/NADH is realized, which is confirmed by time-of-flight secondary ion mass spectrometry.
3-Cyanopyridine as a bridging and terminal ligand in coordination polymers
Authors: Heine Miriam , Fink Lothar , Schmidt Martin U.
Published: November 2018

Crystal structures of [MIIBr2(3-CNpy)x](n) with M = Mn, Fe, Co, Ni and x = 1, 2, 4 were determined by powder diffraction. For x = 1, the 3-cyanopyridine ligand is bridging two metal atoms.
Origins of optical defects in rapidly grown DKDP crystals
Authors: Piquard Juliette , Zaccaro Julien , Pintault Bruno , Maunier Cédric , Ibanez Alain
Published: November 2018

Origins of the optical perturbations observed in slabs cut from rapidly grown DKDP crystals were identified. One is related to a post growth aging specific to DKDP and the other is a growth related segregation of traces of impurity. In addition, we propose a model which allows estimating the contribution of both origins to the observed optical heterogeneities.
Interaction between nanoparticles and charged phospholipid membranes
Authors: Huang Beibei , Tan Zhi , Bohinc Klemen , Zhang Shuxing
Published: November 2018

Charged lipids in cell membranes and subcellular organelles are arranged in the form of a bilayer with the hydrocarbon tails sequestered away from the water and the polar head groups exposed to the aqueous environment.
Comparing the molecular and global rheology of a fluid under high pressures
Authors: Dench J. , di Mare L. , Morgan N. , Wong J. S. S.
Published: November 2018

Microviscosity of PAO 8 measured from the fluorescence anisotropy of Nile red ηA compared to the corrected area-averaged viscosity from friction η* and high-pressure rheology η.
Molecular dynamics study on the heterogeneous nucleation of liquid Al–Cu alloys on different kinds of copper substrates
Authors: Lin Honghui , Li Tao , Li Hui
Published: November 2018

Compared with solidification of Al–Cu alloys frozen on the single substrate, Al–Cu alloys frozen on the confined space and grooved substrates have different structures and shape patterns.
Isolation of reactive Ln(ii) complexes with C5H4Me ligands (CpMe) using inverse sandwich countercations: synthesis and structure of [(18-crown-6)K(μ-CpMe)K(18-crown-6)][CpMe3LnII] (Ln = Tb, Ho)
Authors: Huh Daniel N. , Ziller Joseph W. , Evans William J.
Published: November 2018

We report that crystallographically-characterizable Ln(ii) complexes of Tb and Ho can be isolated by reducing CpMe3Ln(THF) with KC8in THF in the presence of 18-crown-6 (18-c-6).
Lewis adduct formation of hydrogen cyanide and nitriles with arsenic and antimony pentafluoride
Authors: Saal Thomas , Christe Karl O. , Haiges Ralf
Published: November 2018

The reactions of hydrogen cyanide, butyronitrile, cyclopropanecarbonitrile, pivalonitrile and benzonitrile with arsenic pentafluoride and antimony pentafluoride result in the formation of 1 : 1 Lewis adducts, while malononitrile yielded both 1 : 1 and 1 : 2 Lewis adducts.
Ligand exchange processes in zirconocene dichloride–trimethylaluminum bimetallic systems and their catalytic properties in reaction with alkenes
Authors: Parfenova Lyudmila V. , Kovyazin Pavel V. , Gabdrakhmanov Vener Z. , Istomina Galina P. , Ivchenko Pavel V. , Nifant'ev Ilya E. , Khalilov Leonard M. , Dzhemilev Usein M.
Published: November 2018

The exchange processes in the system L2ZrCl2–(AlMe3)2 and its reactivity towards the alkene were studied.
Predictive quantitative structure–property relationship (QSPR) modeling for adsorption of organic pollutants by carbon nanotubes (CNTs)
Authors: Roy Joyita , Ghosh Sulekha , Ojha Probir Kumar , Roy Kunal
Published: November 2018

Nanotechnology has introduced a new generation of adsorbents like carbon nanotubes (CNTs), which have drawn a widespread attention due to their outstanding ability for the removal of various inorganic and organic pollutants.
Humic acid removal by gas–liquid interface discharge plasma: performance, mechanism and comparison to ozonation
Authors: Cui Yanyan , Yu Jianwei , Su Ming , Jia Zeyu , Liu Tingting , Oinuma Gaku , Yamauchi Tokiko
Published: November 2018

A novel advanced oxidation process (AOP) based on plasma in gas–liquid interface discharge was evaluated for humic acid removal. Much better performance was obtained compared to ozonation. The OH˙ radicals generated by reaction of in situ produced ozone and H2O2 during discharge process were mainly responsible for the removal.
Ultrasound assisted ZnO coating in a microflow based photoreactor for selective oxidation of benzyl alcohol to benzaldehyde
Authors: Nair Vaishakh , Colmenares Juan Carlos , Lisovytskiy Dmytro
Published: November 2018

Heterogeneous photocatalysis in a microflow system for generation of value added chemicals is a novel green chemistry approach requiring the understanding of photocatalysis, microfluidics and reactor design.
Thimerosal inhibitsDrosophila melanogastertyrosine hydroxylase (DmTyrH) leading to changes in dopamine levels and impaired motor behavior: implications for neurotoxicity
Authors: Bianchini Matheus C. , Gularte Claudia Ortiz Alves , Nogara Pablo A. , Krum Bárbara N. , Gayer Mateus C. , Bridi Jessika C. , Roos Daniel H. , Roehrs Rafael , Fachinetto Roselei , Pinton Simone , Ávila Daiana S. , Hirth Frank , Rocha João B. T. , Puntel Robson L.
Published: November 2018

Thimerosal (THIM) is a well-established antifungal and antiseptic agent widely used as a preservative in vaccines.
Intracellular low-abundance microRNA imaging by a NIR-assisted entropy-driven DNA system
Authors: Lu Huiting , Yang Fan , Liu Benhan , Zhang Kai , Cao Yu , Dai Wenhao , Li Wenjun , Dong Haifeng
Published: November 2018

A NIR-assisted elegant entropy-driven DNA probe for highly sensitive catalytic imaging of low-abundance miRNA in living cells and in vivo.
Syntheses, structural diversity and photocatalytic properties of three coordination polymers assembled by different N-heterocyclic ligands
Authors: Zhang Xiaoyin , Zhang Xia , Fan Chuanbin , Zong Ziao , Zhang Dongmei , Bi Caifeng , Fan Yuhua
Published: November 2018

The diversity of ligands and central metal ions plays an important role not only in coordination modes and final products but also in their photocatalytic activities.
Water-soluble copper(i) complexes bearing 2,2′-bicinchoninic acid dipotassium salt with red-light absorption and repeatable colour change upon freezing operation
Authors: Saito Yuma , Nishikawa Michihiro , Tsubomura Taro
Published: November 2018

The repeatable colour change upon freezing–melting operation of a water solution of a Cu(i) complex is found. Efficient red light absorption is also one of the advantages of this complex.
Red-emitting dyes based on phenothiazine-modified 2-hydroxychalcone analogues: mechanofluorochromism and gelation-induced emission enhancement
Authors: Gao Hongqiang , Xue Pengchong , Peng Jiang , Zhai Lu , Sun Meng , Sun Jingbo , Lu Ran
Published: November 2018

Red-emitting mechanofluorochromic dyes based on phenothiazine-modified 2-hydroxychalcone analogues.
Correction: Rationalising the effects of ionic liquids on a nucleophilic aromatic substitution reaction
Authors: Hawker Rebecca R. , Wong Michaela J. , Haines Ronald S. , Harper Jason B.
Published: November 2018

Correction for ‘Rationalising the effects of ionic liquids on a nucleophilic aromatic substitution reaction’ by Rebecca R. Hawker et al., Org. Biomol. Chem., 2017, 15, 6433–6440.
Unlocking the action mechanisms of molecular nonlinear optical absorption for optical conjugated polymers under aggregation states
Authors: Huang Jin , Zheng Dong , Peng Bang'an , Kong Menghao , Hang Yixiao , Ma Jing , Jia Xudong
Published: November 2018

Controlling the molecular microstructure and the molecular aggregation state under different conditions to improve the MNOA performance of OCPs.
Synthesis of sheet-coil-helix and coil-sheet-helix triblock copolymers by combining ROMP with palladium-mediated isocyanide polymerization
Authors: Pomarico Scott K. , Lye Diane S. , Elacqua Elizabeth , Weck Marcus
Published: November 2018

A new methodology towards architecturally well-defined covalent triblock copolymers is presented.
Synthesis, crystal and electronic structure, physical properties and121Sb and151Eu Mössbauer spectroscopy of the Eu14AlPn11series (Pn = As, Sb)
Authors: Radzieowski Mathis , Block Theresa , Klenner Steffen , Zhang Yuemei , Fokwa Boniface P. T. , Janka Oliver
Published: November 2018

Structure and property investigations of the Zintl phases Eu14AlAs11and Eu14AlSb11: magnetism, electrical resistivity, Mössbauer spectroscopy and theoretical calculations.
Visible-light-mediated direct synthesis of phosphorotrithioates as potent anti-inflammatory agents from white phosphorus
Authors: Lu Guozhang , Chen Jun , Huangfu Xinlei , Li Xueyan , Fang Meijuan , Tang Guo , Zhao Yufen
Published: November 2018

The reaction of P4 with arylthiols in the presence of Na2–eosin Y under visible light gave phosphorotrithioites. Subsequent oxidation of phosphorotrithioites produced phosphorotrithioates. The phosphorotrithioate 3f presents good inflammation reducing characteristics.
Spin-echo small-angle neutron scattering (SESANS) studies of diblock copolymer nanoparticles
Authors: Smith Gregory N. , Cunningham Victoria J. , Canning Sarah L. , Derry Matthew J. , Cooper J. F. K. , Washington A. L. , Armes Steven P.
Published: November 2018

Concentrated dispersions of polymer nanoparticles with high contrast can be studied using SESANS in real space.
QRREM method for the isolation of high-quality RNA from the complex matrices of coconut
Authors: Iqbal Amjad , Yang Yaodong , Qadri Rashad , Wu Yi , Li Jing , Shah Farooq , Hamayun Muhammad , Hussain Anwar
Published: November 2018

Complex plant tissues vary in hardness, i.e. some are succulent, while others are complex to break. Besides, plant metabolites, such as polysaccharides, proteins, polyphenols and lipids, can greatly interfere with the RNA extraction. So, in order to obtain a high-quality RNA from the complex tissues (like coconut endosperm, coconut apple and coconut leaf bud) rich in secondary metabolites, a robust method is demanded. Several methods (MRIP, CTAB and TRIZOL) have been used previously for the isolation of quality RNA from the coconut tissues, but without any success. The present study will provide with the details of a new method (Quick and Reliable RNA Extraction Method or QRREM), which have efficiently isolated the intact RNA form the complex tissues of coconut compared with CTAB, Trizol and RNA plant. The method has been validated for the isolation of high-quality intact RNA from the other available plant species (Areca/betel nut, mint and spring onion). The method has various advantages over the other methods in terms of time and cost effectiveness. Furthermore, the resulted RNA from various tissues of coconut performed well in the downstream experiments, i.e. reverse transcription and PCR for the production and amplification of cDNA.
Anti-tumoral potential of MDA19 in human osteosarcoma via suppressing PI3K/Akt/mTOR signaling pathway
Authors: Liu Bin , Xu Liang , Dai E-Nuo , Tian Jia-Xin , Li Jian-Min
Published: November 2018

Osteosarcoma (OS) is the most common primary malignancy of skeleton with higher mortality rates amongst children and young adults worldwide, whereas effective and secure therapies have also been sought by researches with ongoing efforts. The purpose of the present study was to investigate the impact of N′-[(3Z)-1-(1-hexyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene] benzohydrazide (MDA19) on OS and explore its potential mechanism. Cell Counting Kit-8 (CCK8) and colony formation assay were employed to evaluate the potential effect of MDA19 on U2OS and MG-63 cells proliferation. Moreover, transwell migration and invasion assay were performed to assess the influence of MDA19 on U2OS and MG-63 cells migration and invasion. In addition, Annexin V-FITC/propidium iodide (Annexin V-FITC/PI) staining and flow cytometry were used to examine apoptotic ratio of the U2OS and MG-63 cells. Meanwhile, Western blot analysis was applied to explore change of relevant mechanism proteins in OS cells treated with MDA19. Our study showed that MDA19 had anti-proliferative activity of OS cells in a dose- and time-dependent manner, simultaneously, inhibition of colony formation was also observed in U2OS and MG-63 cells after incubation of MDA19. Besides, MDA19 could significantly inhibit the number of migrated and invaded OS cells and markedly increase the OS cells apoptosis rate. Mechanistically, we detected detectable reductions in apoptosis related proteins, epithelial–mesenchymal transition (EMT)-related proteins and activity of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling in U2OS and MG-63 cells exposure to MDA19. Overall, the current study indicates in vitro anti-proliferative, anti-metastatic, and pro-apoptotic potential of MDA19 in U2OS and MG-63 cells. Our findings propose a clue for further studies with this compound in preclinical and clinical treatment for OS.
Context-dependent spindle pole focusing
Authors: Borgal Lori , Wakefield James G.
Published: November 2018

The formation of a robust, bi-polar spindle apparatus, capable of accurate chromosome segregation, is a complex process requiring the co-ordinated nucleation, sorting, stabilization and organization of microtubules (MTs). Work over the last 25 years has identified protein complexes that act as functional modules to nucleate spindle MTs at distinct cellular sites such as centrosomes, kinetochores, chromatin and pre-existing MTs themselves. There is clear evidence that the extent to which these different MT nucleating pathways contribute to spindle mass both during mitosis and meiosis differs not only between organisms, but also in different cell types within an organism. This plasticity contributes the robustness of spindle formation; however, whether such plasticity is present in other aspects of spindle formation is less well understood. Here, we review the known roles of the protein complexes responsible for spindle pole focusing, investigating the evidence that these, too, act co-ordinately and differentially, depending on cellular context. We describe relationships between MT minus-end directed motors dynein and HSET/Ncd, depolymerases including katanin and MCAK, and direct minus-end binding proteins such as nuclear-mitotic apparatus protein, ASPM and Patronin/CAMSAP. We further explore the idea that the focused spindle pole acts as a non-membrane bound condensate and suggest that the metaphase spindle pole be treated as a transient organelle with context-dependent requirements for function.
General range model for multi‐channel SAR/GMTI with curvilinear flight trajectory
Authors: Chen Zhanye , Zhou Yu , Zhang Linrang , Wei Honghao , Lin Chunhui , Liu Nan , Wan Jun
Published: November 2018

The platform of multi‐channel synthetic aperture radar/ground moving target indication (MC‐SAR/GMTI) system may encounter the problem of curvilinear trajectory due to the existence of acceleration in several applications, e.g. manoeuvring responding, orbital motion, and long‐time observing. The curvilinear trajectory changes the attitude of the array, which leads to instantaneous baseline changing during echo reception. Thus, the traditional constant baseline range model is no longer valid since it will introduce severe phase error. In this Letter, a general range model that it applies to both stationary and moving targets for MC‐SAR/GMTI is proposed. Simulation results of the point spread functions demonstrate that the proposed model can achieve good performance.
Fe I in the β Pictoris circumstellar gas disk
Authors: Kiefer F. , Vidal-Madjar A. , Lecavelier des Etangs A. , Bourrier V. , Ehrenreich D. , Ferlet R. , Hébrard G. , Wilson P. A.
Published: November 2018

The young planetary system β Pictoris is surrounded by a debris disk of dust and gas. The gas source of this disk could be exocomets (or “falling and evaporating bodies”, FEBs), which produce refractory elements (Mg, Ca, Fe) through sublimation of dust grains at several tens of stellar radii. Nearly 1700 high resolution spectra of β Pictoris were obtained between 2003 and 2017 using the HARPS spectrograph. In Paper I, we showed that a high signal to noise ratio allows the detection of many weak Fe I lines in more than ten excited levels, and we derived the physical characteristics of the iron gas in the disk. The measured temperature of the gas (~1300 K) suggests that it is produced by evaporation of grains at about 0.3 au (38 R⋆) from the star. Here, we describe the yearly variations of the column densities of all Fe I components (from both ground and excited levels). The drop in the Fe I ground level column density after 2011 coincides with a drop in Fe I excited levels column density, as well as in the Ca II doublet and a ground level Ca I line at the same epoch. All drops are compatible with photoionisation-recombination equilibrium and β Pic like relative abundances, in a medium at 1300 K and at 0.3 au from β Pictoris. Interestingly, this warm medium does not correlate with the numerous exocomets in the circumstellar environnement of this young star.
Single-top and top-antitop cross sections
Authors: Kidonakis Nikolaos
Published: November 2018

I present high-order calculations, including soft-gluon corrections, for single-top and top-antitop production cross sections and differential distributions. For single-top production, results are presented for the three different channels in the Standard Model, for associated production with a charged Higgs, and for processes involving anomalous couplings. For top-antitop pair production, total cross sections and top-quark transverse-momentum and rapidity distributions are presented for various LHC energies.
A tale of two Regge limits
Authors: Del Duca Vittorio
Published: November 2018

In light of the strong advances in understanding the mathematical structure of scattering amplitudes, we discuss the Regge limit of QCD and of theN= 4 Super Yang-Mills theory.
Holographic description of total hadronic cross sections at high energies
Authors: Watanabe Akira , Huang Mei
Published: November 2018

We investigate the hadron-hadron total cross sections at high energies in the framework of holographic QCD. In our model setup, the involved strong interaction is described by the Brower-Polchinski-Strassler-Tan Pomeron exchange kernel, and the two form factors are obtained from the bottom-up AdS/QCD models. We show that the resulting nucleon-nucleon total cross section is consistent with the experimental data recently measured by the TOTEM collaboration at the LHC. As examples to see the general versatility of the model, we also present our analysis on the pion-nucleon and pion-pion cases, which can be predicted because all the adjustable parameters are fixed by the nucleon-nucleon data.
Isotopic distribution and dependency to fission product kinetic energy for 241Pu thermal neutron-induced fission
Authors: Julien-Laferrière S. , Kessedjian G. , Serot O. , Chebboubi A. , Bernard D. , Blanc A. , Köster U. , Litaize O. , Materna T. , Meplan O. , Rapala M. , Sage C.
Published: November 2018

Nuclear fission yields data measurements for thermal neutron induced fission of 241Pu have been carried out at the ILL in Grenoble, using the Lohengrin mass spectrometer. The relative isotopic yields for the masses 137 up to 141 have been derived with the associated experimental covariance matrices. Moreover, from preliminary results for the masses 92, 138 and 139, a clear evolution over fission product kinetic energy of the isotopic total count rate is observed.
Application of Calorimetric Low-Temperature Detectors for the Investigation of Z-Yield Distributions of Fission Fragments
Authors: Dubey Santwana , Echler Artur , Egelhof Peter , Grabitz Patrick , Mutterer Manfred , Lauterfeld Werner , Stolte Stefan , Blanc Aurelien , Köster Ulli , Kraft-Bermuth Saskia , Scholz Pascal , Bishop Shawn , Gomez Jose , Gönnenwein Friedrich
Published: November 2018

In recent experiments, the new concept of calorimetric low-temperature detectors (CLTDs) was applied for the first time for the investigation of isotopic yields of fission fragments. Fragments from neutron-induced fission sources were mass-separated by the LOHENGRIN spectrometer at the ILL Grenoble and, after passing silicon nitride membranes used as degraders, detected in a CLTD array. The new detector concept of a thermal detector provides a fundamental advantage over conventional ionization-mediated detectors, in particular for heavier particle masses at low energies. Using fissile targets of235U,239Pu and241Pu, nuclear-charge separation was studied in the mass region 82 ≤ A ≤ 139. For light fragments, the Z resolution matches historically best values with conventional techniques, while for heavier masses substantial improvement was attained. We have gained first LOHENGRIN data on the isotopic yields in the light-mass group of241Pu. Towards mass-symmetry, known Z-yield data were supplemented in the range A = 110 to 113 for241Pu and239Pu. Extended data sets were cumulated for A = 92 and 96 due to a recent request from studies on the reactor anti-neutrino spectrum. Furthermore, considerable progress was achieved to extend isotopic yield measurements up to the heavy-mass region, hardly accessible until now.
Neutron-rich isotopes from 238U(n,f) and 232Th(n,f) studied with the ν-ball spectrometer coupled to the LICORNE neutron source
Authors: Wilson Jonathan , Lebois Matthieu , Qi Liqiang
Published: November 2018

We have recently successfully demonstrated a new technique for production and study of many of the most exotic neutron-rich nuclei at moderate spins. LICORNE, a newly developed directional inversekinematic fast neutron source at the ALTO facility of the IPN Orsay, was coupled to the MINIBALL γ-ray spectrometer to study very neutron rich nuclei using the 238U(n,f) reaction. This reaction and 232Th(n,f), are the most neutron-rich fission production mechanisms achievable and can be used to simultaneously populate hundreds of neutron-rich nuclei up to spins of ~16h. High selectivity in the experiment was achieved via triple γ-ray coincidences and the use of a 400 ns period pulsed neutron beam, a technique which is unavailable to other reaction mechanisms such as spontaneous fission. The pulsing allows time correlations to be exploited to separate delayed γ rays from isomeric states and supresses unwanted γ-rays from beta decay. In Autumn 2017, the ν-ball array will be operational at the ALTO facility of the IPN Orsay. This high efficiency hybrid Ge-LaBr3 spectrometer based around 24 clover Ge detectors, 10 co-axial Ge detectors and 20 LaBr3 scintillators will help to further refine the technique and achieve a large increase in the current observational limit.
The equation of motion phonon method and its application in the neutron rich oxygen region
Authors: De Gregorio G. , Knapp F. , Lo Iudice N. , Veselý P.
Published: November 2018

An equation of motion phonon method, developed for even-even nuclear systems and extended to odd nuclei, is applied to 22O and to its odd neighbors 23O and 23F. A calculation using the chiral potential NNLOopt is carried out in a space encompassing up to two phonons. The computed dipole cross section in 22O and the spectra of 22O and 23O are in a satisfactory agreement with the experimental data. However, the calculation describes poorly the spectrum of 23F. This discrepancy originates from the strong coupling between the odd proton and the 22O phonons of neutron nature. This coupling pushes down in energy several states enhancing the level density at low energy. We suggest that a viable route for the solution of this problem could be the inclusion of the three-body interaction using the new chiral potential NNLOsat.
A study on the transition between seniority-type and collective excitations in 204Po and 206Po
Authors: Stoyanova Milena , Rainovski Georgi , Jolie Jan , Pietralla Norbert , Blazhev Andrey , Djongolov Martin , Esmaylzadeh Arwin , Gerhard Lisa , Gladnishki Kalin , Karayonchev Vasil , Keatings James , Kern Ralph , Kocheva Diana , Kröll Thorsten , Mashtakov Konstantin , Möller Oliver , Régis Jean-Marc , Scheck Marcus , Schomacker Kerstin , Sinclair Jacqueline , Sürder Chistian , Werner Volker , Wiederhold Johannes
Published: November 2018

Low-lying yrast states in 204Po and 206Po have been investigated by the γ-γ fast timing technique with LaBr3(Ce) detectors. Excited states of these nuclei were populated in the 197Au(11B,4n) and the 198Pt(12C,4n) fusion-evaporation reactions, respectively, at the FN-Tandem Facility at the University of Cologne. The lifetimes of the 4+1 states in both nuclei were measured, along with an upper limit for the 2+1 state in 204Po. The preliminary results are discussed in the scope of the systematic behavior of the transition strengths between yrast states in polonium isotopes.
Model Verification for Material Parameters of Titanium Alloy Ti-6AL-4V and Steel
Authors: Zhu Guanfang , Li Chunwang , Zhang Zhongping
Published: November 2018

To carry out numerical simulation of TC4 titanium alloy blade impacted by foreign objects effectively, this paper takes the test results of steel ball and sandstone impacting titanium alloy flat blade inlet and blade surface as the benchmark, and uses ANSYS/LS-DYNA software to adopt kinematic hardening plasticity model to simulates the impact results and inverts the contact stiffness factor and the other three parameters were obtained by the way of inversion reasoning.
Research on Optimization Algorithm of RSSI Positioning Parameters Based on Improved Particle Swarm Optimization
Authors: Ji Qiang , Zhang Shifeng , Zhao Haoguang
Published: November 2018

The paper put forward to an algorithm based on hybrid mutation particle optimization swarm strategy (HMPOA), it can solve the position coordinates of the unknown nodes. The algorithm uses static sampling to determine the performance index values of particles, then the arc grouping method is used to divide the particle swarm into several subgroups. Finally, the hybrid mutation strategy is used to improve the convergence speed and positioning accuracy of the algorithm, which can overcome the location accuracy of unknown node that overly dependent on the RSSI physical measurement value. Numerical experiments show that the algorithm has fast convergence speed and high positioning accuracy for unknown nodes, and it is feasible for RSSI positioning.
Oscillation Criteria of Second-Order Mixed Neutral Delay Dynamic Equations on Time Scales
Authors: Feng L M , Zhao Y G , Shi Y L , Han Z L
Published: November 2018

In this artical, we consider a second-order neutral dynamic equation on a time scales. A number of oscillation theorems are shown that supplement and extend some known results in the eassay.
Design of Tracking and Capturing Method for Abnormal Behavior in Marketing System Based on Sandbox Technology
Authors: Li Yunzhao
Published: November 2018

In this paper, a tracking and capturing method for abnormal behavior in marketing system is designed. The main steps of the method include: (1) Trace generation based on function injection. This method selects NOP, HLT and other instructions of untrusted processes to fill the memory area, and injects the test. The function and control process execute the function to obtain Trace; (2) Trace & capture-based sandbox interception system function analysis method, first establish a finite state automaton model describing the instruction address translation of the untrusted process call system function, according to the state of the automaton. The conversion determines whether the system function calling process has interception behavior, and further identifies the system function of the sandbox interception according to the position of the state machine conversion instruction in the automatic machine. This paper designs and implements the prototype system, called TC-analyser, and solves the key problems of the function injection timing selection, Trace intermediate representation and other implementation processes. Finally, choose Chromium and Adobe Reader to test the TC-analyser’s interception recognition capability and compare it with Hooks hark. The experimental results show that the TC-analyser has good interception and recognition capabilities.
Image Enhancement by Frequency Analysis
Authors: Yao Chen , Xia Yan , Zhu Jiamin
Published: November 2018

Because of lighting or the quality of CMOS/CCD, poor images are often gained, which greatly affect subjective observation. Image enhancement can improve the contrast of poor image. In our paper, we propose a new image enhancement algorithm based on frequency analysis. A central energy of FFT is utilized for computation of image enhancement factors. A linear mapping is used for image mapping. Finally, some experimental results are shown for illustration of our algorithm advantage.
Mapping of landslide hazards prediction using geographic information system in Solok District
Authors: Abdurrohim  , Firman Hidayat
Published: November 2018

Solok District is one of the areas prone to the landslide in West Sumatera Province. Generally, landslides are caused by natural and human factors. The aims of this study are to predict the location of the highest landslide hazard distribution in Solok District and to know the level of vulnerability of landslide hazards in Solok District. This study consists of preparatory steps, field survey, analysis and processing of the data based on 4 types of maps, i.e. rainfall, soil type, geological, and slope maps. These maps then scoring in 5 types of vulnerability levels. As the results of this study, it is known that the sub-districts are on the highest prediction of the landslide are Pantai Cermin, Lembah Gumanti, Hiliran Gumanti, Lake Kembar, Mount Talang, Payung Sekaki, Tigo Lurah, Bukit Sundi, Kubung, X Koto Singkarak and Junjung Sirih. The level of vulnerability prediction of landslide hazard in Solok District is divided into 5 levels, which is very low 44511,71 Ha with percentage of 11,91%, low of 69179,34 Ha with percentage 18,51%, while 89894.35 Ha with the percentage of 24.05%, height of 86307 Ha with the percentage of 23.09%, and very high 83907,60 Ha with the percentage of 22.45.
The prediction of tsunami travel time to Mataram City Indonesia based on North Lombok earthquake as the initial condition
Authors: Pradjoko Eko , Wardani Lukita , Hartana  , Sulistiyono Heri , Syamsidik
Published: November 2018

The past earthquake records in North Lombok show the high level of earthquake hazard in this area. The maximum magnitude of the earthquake was 6.4 Mw on May 30th, 1979. But, there were no tsunami events records due to those earthquakes. Nevertheless, this area is very close to Mataram City (province capital city) and tourism area. Therefore, the assessment of tsunami hazard is very important. The tsunami simulation was conducted by using COMCOT Model, which is based on the North Lombok Earthquake as the initial condition. The simulation result shows the prediction of tsunami travel time is about 18 ~ 20 minutes from the source location to Mataram City. The height of the tsunami wave is 0.13 ~ 0.20 meters due to the earthquake magnitude is about 6 Mw.
Spatial and statistical analysis on the cause of flooding in Northwest Jakarta floodplain (Kapuk and Penjaringan Districts)
Authors: Priambodo Imam , Tambunan Mangapul P. , Kusratmoko Eko
Published: November 2018

Jakarta, as the capital city of Indonesia, is one of the most flooded areas in Indonesia. The floods occurred annually and heavy floods usually occurred once in a few years. This paper address the geographic distribution of floods and statistical analysis of the floods causes by using rain intensity, tidal height, elevation, and floods occurrence as the parameters. This research was conducted in Angke (Kapuk) and Penjaringan Districts, located in Northern Jakarta where the floods usually occur. The result shows that rainfall intensity, remaining water inundation from the previous flood, and land runoff coefficient as the key factors of flooding in these areas.
Development and implementation of algorithms of building structure engineering calculations for shear fraction under pressing-through.
Authors: Dmytrenko Tetiana , Semko Oleksandr , Dmytrenko Andrii , Derkach Tetiana , Voskobiinyk Olena
Published: November 2018

Development of calculating algorithms for designed and patented constructive solutions for beamless monolithic slab and concrete reinforced column connection in the form of software program is presented in this article. Also a mathematical model for the constructive solutions was created using finite elements method. A theoretical part of the research includes engineering technique for the connection nodes between monolithic concrete slab and reinforced concrete column in stress strain state. A technical goal is simplifying and reliability increasing of loading capacity of the junction and assembly work facilitation along with reducing building frame costs. To perform testing of connection nodes between monolithic reinforced concrete beamless non-bearing slab and reinforced concrete column for shear existing calculating algorithm was improved using the designed formula. A connection node for a shear along the column body calculation according to the technique was also implemented as a software program. A technique for calculating a connection node between monolithic beamless non-capital concrete reinforced slab and concrete reinforced columns was developed. Visual Basic for Applications was used to automate calculating of the connection nodes for shear. The research results have been implemented into practical design and calculation during extension of manufacturing building of Skvira confectionary shop in Skvira settlement.
Methodological and computer-based support for choosing underground utility networks renovation method
Authors: Goncharenko Dmitriy , Shumakov Ihor , Starkova Olha , Aleinikova Alevtyna , Mikautadze Revaz
Published: November 2018

The article is devoted to the methodological and software tools for choosing organizational and technological solutions to maintain sewage collectors in an operable state to increase their service life. Such a tool must take into account a set of factors that affect the operation of sewer collectors and form a system, the implementation of which would improve the existing principles of monitoring the status of sewer collectors, identify effective organization and technological solutions of their renovation by taking into account factors that affect their safe operation, the facilities risk of accidents categories, conditions and parameters of works performance. For determining the optimal options for the renovation of the sewer collector using the developed mathematical and computer models, the results of problems solving were generalized: one-criterion optimization subject to the choice of one repair method; one-criterion optimization subject to the choice of different repair methods for the areas; multicriterion optimization.
Efficient method of eliminating accidental damage of sewer tunnel
Authors: Goncharenko Dmitriy , Starkova Olga , Aleinikova Alevtyna , Kolomiiets Yulyia , Greenchuk Oksana
Published: November 2018

The article is devoted to the development of technological and organizational solutions for elimination of local emergency damage to sewage tunnel collectors. In the article, conditions of operation and constructions of the sewage tunnel collector destroyed by corrosion are investigated on Grekovska street in Kharkiv, Ukraine; the methods of production of repair and restoration works are analyzed in this article; technological and organizational solutions have been developed for the liquidation of emergency damage to sewage tunnel collectors, taking into account technical, organizational and economic indicators. Thus, when comparing recovery options by different methods, it is noted that the proposed technology is more economically feasible in view of the relatively low cost of the material for this solutions. At the same time, the duration of the work by the proposed method of extrusion by introducing a secondary lining with anticorrosive properties will be reduced by 30%.