bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Charactrization of some Hetrocyclic Compounds from Ninhydrin and Study of its Effect on Amylase Enzyme in Serum
Authors: Q. Abdalla Ibtihal
Published: November 2023

Ninhydrin is a chemical compound that is commonly used in analytical chemistry. In this research, ninhydrin was utilized to prepare some heterocyclic derivatives. It was reacted with hydrazine to make compound (1), which was the starting material to synthesize other heterocyclic derivatives in this research. These compounds were characterized by (FT-IR) and (H-NMR) techniques. The biological effect of the prepared compounds were tested against the activity of amylase enzyme in serum. These compounds resulted in deactivating the amylase enzyme in a percentage rate of (11.43, 36.49) %, which proves their effectiveness against the enzyme.
The Effect of Aqueous and Alcoholic Extract of Ziziphus Spina-christi on some Bacterial Isolates Causing Gingivitis
Authors: I. Hamad Abdullah
Published: November 2023

Bacterial gingivitis is a most common and mild form of periodontal disease that causes bleeding, redness and swelling (inflammation) of gingiva, around the cervical area of teeth. Untreated gingivitis can progress to periodontal disease, periodontitis, by spreading to supporting tissue of teeth involving bone and periodontal ligament, a much more serious condition that can lead to tooth loss. The study was conducted to investigate the bacteria causing gingivitis with an attempt to investigate the bacterial inhibitory effect of seder leaves extract. Samples consist from (230) gingivitis swab were collected from the patients which are admitted to dental clinics in Tikrit city , among the period extended from March 2016 to February 2017 .Cultural, microscopical and biochemical tests were performed to identify the bacteria causing gingivitis .The results showed 165positive heavy culture of causative bacteria as follows :Gram positive ; Streptococcus mutans (% 18.78 ) , Streptococcus pyogens (% 8.48 ), Streptococcus salivarius (% 6.06 ) , Streptococcus angiosus (% 4.84 ) ,Streptococcus pneumoniae (%3.03 ), Staphylococcus aureus (% 16.96 ), Staphylococcus epidermidis (% 9.09 ) ,while gram negative included Pseudomonas aeruginosa (% 13.93),Escherichia coli (% 9.69 ) ,Klebsiella .spp (%6.66) , and finallyPseudomonas monilli (%2.42).The present study showed that the aqueousand alcoholic extract of Ziziphus spina-christi leaves had inhibitory activity agiants the bacterial species . At the concentration of (200 mg/ml) of seder leaves extract showed the highest effect on bacteria . All the types of bacteria that isolated from the patients with gingivitis had revealed disproportionately sensitivity against antibiotics : Amikacin , ampicillin , tetracycline , gentamicin , chliromphenicol , nalidixic acid , amoxicillin , trimethoprim .The mixture of aqueous extract of seder leaf and antibiotic Gentamicin , Amikacin and amoxicillin revealed high inhibitory synergetic effect against aginst resistant bacteria.
Neural Network Model of Surface Tension of Hydrocarbon–Alcohol Binary Mixtures
Authors: Amouei Hamed , Lashkarbolooki Mostafa , Movagharnejad Kamyar
Published: November 2023

Since the correlation of surface tension of hydrocarbons and alcohol mixtures has great importance, this study is aimed to propose an artificial neural network model to correlate this thermodynamic property. To calculate the best network architecture and the optimal number of neurons, five sets of input variables and two transfer functions are examined. The results reveal that a feed-forward network with the structure of 5-14-1 and logsis and purelin as transfer functions for hidden and output layers, respectively, leads to the best accuracy. Moreover, it is revealed that choosing temperature, mole fraction, molecular weight of hydrocarbons, molecular weight of alcohols, and critical temperature as input variables can be efficient for an accurate correlation of the surface tension of selected chemicals. The results of the proposed artificial neural network model are also compared to the Shereshefsky and Langmuir thermodynamic models. The results obtained from 34 binary mixtures show the generality and acceptable accuracy of the proposed feed-forward network (with an average absolute relative deviation [AARD] of 0.36%) compared to the Shereshefsky (with an AARD of 0.37%, obtained for 31 binary mixtures) and Langmuir (with an AARD of 0.52%) thermodynamic models.
STRATEGY OF STATE SUPPORT FOR INNOVATIVE TECHNOLOGIES FOR THE DEVELOPMENT OF THE AGRO-INDUSTRIAL COMPLEX IN THE CONTEXT OF INFORMATION SECURITY
Authors:   Chernihiv Polytechnic National University, Marhasova Viktoriia , Shevtsova Olena ,   Chernihiv Polytechnic National University
Published: November 2023

In the course of substantiating the prospects for state regulation of innovative development of the agro-industrial complex in the context of digital transformation, the study synthesized a set of provisions that specify the author's views on these issues, revealing the features of combining and combining tools and processes aimed at activating innovations in the industry.The main objective of the study is to develop a strategy for state support of inno-vative technologies for the development of the agro-industrial complex in the context of Infor-mation Security.To ensure the innovative development of theagro-industrial complex as a sphere that hinders the speed of innovative transformations of the national economy in the process of its digital transformation, it is necessary to implement state regulation, which con-tributes to the activation of the innovative potential of the most receptive and deserving tar-geted support for industry participants. Organizational and institutional parameters of such support are determined by the order and content of measures that include the mechanism of state regulation ofinnovative development of the agro-industrial complex ecosystem developed by the author in the context of digital transformation.
A clinical case of intravitreal implant dexamethasone (Ozurdex) using in treatment of macular edema associated with non-infectious uveitis
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Danilova L.P. ,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation,   Far-Eastern State Medical University, Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Storozhilova D.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Shulga A.E. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Emanova L.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation
Published: November 2023

Purpose. Demonstration of a clinical case of macular edema treatment associated with non-infectious uveitis by intravitreal injection of a dexamethasone implant (Ozurdex). Material and methods. A clinical case of uveitis associated with rheumatoid arthritis in a 34-year-old female patient is presented. She underwent sequential two intravitreal injections (IVI) of long-acting dexamethasone (Ozurdex implants), with an interval of 3 months. Results. 3 days after Ozurdex IVI Vis OD = 1.0, Vis OS = 0.8 (initially 0.2), intraocular pressure (IOP) OD = 18 mmHg, IOP OS = 19 mmHg. A single cell suspension remained in the vitreous body. The retinal thickness in the macula decreased to 314.5 µm (initial 725.2 µm), and macula volume decreased to 14.1 mm³(initially 18.5 mm³ ). 3 months after IVI of Ozurdex in the vitreous: opacification +2 points, the implant was not detected due to its rapid biodegradation. OCT of the macular area again revealed edema with cystic cavities. Ozurdex was reinjected intravitreally. 3 days after the operation, all signs of the inflammatory process were stopped, Vis OD = 1.0, Vis OS = 1.0, IOP OD = 18 mmHg, IOP OS = 18 mmHg. Conclusion. The Ozurdex implant made it possible to achieve complete regression of macular edema and resorption of cell suspension in the vitreous body. The best-corrected visual acuity (BCVA) indicators increased significantly – from 0.4 to 1.0. Keywords: non-infectious uveitis, macular edema, Ozurdex implant, retinal thickness, macular volume.
Study of the effectiveness of the treatment of endothelial vascular dysfunction in various stages of primary open-angle glaucoma
Authors:   Tashkent State Dental Institute, Dusmukhamedova A.M. , Tuychibaeva D.M. ,   Tashkent State Dental Institute
Published: November 2023

Relevance. According to literary sources, POAG is considered as a chain of interaction of etiological and pathogenetic factors, among which the leading role is played by genetic predisposition, general changes, ischemia, primary local functional and dystrophic changes, disturbances in hydrostatics and hydrodynamics of the eye, increased intraocular pressure, vascular disorders, dystrophy and tissue degeneration. Purpose of the study. To assess the severity of endothelial dysfunction in patients with different stages of primary open-angle glaucoma during complex therapy. Material and research methods. The study included 92 patients with POAG aged 65 to 80 years, who were divided into three groups. We studied the levels of endothelin-1, VEGF and von Willebrand factor before and after the recommended treatment in patients with POAG. Conclusion. The developed complex therapy of various stages in patients with POAG contributed to the correction of the identified disorders in relation to markers of endothelial dysfunction. The features of changes in ED markers in patients with POAG have been established; low levels of von Willebrand factor, VEGF and endothelin-1, which indicates the role of pathogenetic factors in the formation of endothelial dysfunction and the importance of studying markers of endothelial dysfunction. Keywords: primary open-angle glaucoma, endothelial markers, von Willebrand factor, VEGF, endothelin-1, complex therapy
Atypical manifestations of the onset of Coats retinitis in childhood
Authors:   State Autonomous Healthcare Institution of the Kemerovo Region “Kemerovo Regional Clinical Hospital named after S.V. Belyaev”, Ivanova S.P. , Yanchenko T.V. ,   State Autonomous Healthcare Institution of the Kemerovo Region “Kemerovo Regional Clinical Hospital named after S.V. Belyaev”, Gromakina E.V. ,   “Kemerovo State Medical University”, Ministry of Healthcare, RF
Published: November 2023

Congenital non-hereditary anomaly of retinal vessels, histologically manifested by the replacement of capillaries with wider ones, dilation of arterioles is Coats retinitis. Increasing the number of patients with this pathology is an urgent issue for the development of clinical recommendations and uniform treatment tactics. Keywords: retinitis of Coats, clinical case, laser photocoagulation of the retina
Service Mark in Library Publishing Activities
Authors: Prasolova Polina S.
Published: November 2023

Nowadays the problem of competent use of service mark in library publishing activity is becoming relevant. This marketing tool has not yet received proper coverage in the publications of specialists from the fi eld of book studies, library science and bibliography. For the successful realization of their own intellectual (including publishing) products of libraries is very important its active promotion to the consumer, so it is necessary to develop an individual brand. One of the ways to solve this problem is the purposeful use of a service mark, created, approved and duly officially registered (according to the norms of the current legislation of the Russian Federation). The article also touches upon some issues related to the legal aspects of individualization of library publishing products.
Formation of Digital Resources On Military History
Authors: Bukreev Alexander I. , Zhabko Elena D.
Published: November 2023

The article deals with the formation of digital resources on military topics by various institutions and organizations, including libraries of various departmental subordination. The results of the research work (RW) “Representation of military history in the modern information environment” of the Information Historical and Scientific Center — the Military Historical Library of the General Staff of the Armed Forces of the Russian Federation (Military Historical Library), conducted in the first half of 2023, are presented. The article presents an overview of modern military-historical resources in the network space. The general characteristics of thematic digital collections are specified, and the peculiarities of military-historical digital collections are identified and the principles of their creation are formulated. The authors emphasize that it is necessary to take into account the pedagogical component, which should be an integral part of Russian educational projects of patriotic nature. Also, an important feature of the newly created resources should be the pedagogical orientation, providing opportunities to support educational projects of a patriotic nature.
Siberia and the Far East in the “Most Reading Region” Competition
Authors: Alshevskaya Olga N.
Published: November 2023

The article analyzes the scientific and practical strategy, aims, criteria and indicators for evaluating the participants of the All-Russian contest “The Most Reading Region” among the subjects of the Federation for the title “Literary Flagship of Russia” (2015— 2022). The winners, laureates, holders of the status of “Territory of Book and Reading” are described; the participation in the competition of the regions of Siberia and the Far East is investigated. Effective solutions and best practices of involving the population in the literary and book environment, implemented within the framework of the contest in the regions that have become literary flagships of Russia: in the Irkutsk region (2018), the Republic of Sakha (Yakutia) (2020), the Novosibirsk region (2022) are analyzed. The subjects of the Siberian Federal District (SFD) and the Far Eastern Federal District (FEFD), which were not among the winners of the competition, are noted. The general trends of activities to promote books and reading in the regions are revealed. The significance of the All-Russian project for the organisers and participants, its impact on the cultural life in the regions is described.
A Story of Three Levels of Sophistication in SCF/KS-DFT Orbital Optimization Procedures
Authors: Sethio Daniel , Azzopardi Emily , Fernández Galván Ignacio , Lindh Roland
Published: November 2023

In this report, three versions of SCF/KS-DFT orbital optimization are described and benchmarked. The methods are a modified version of the gradient type of the direct inversion in the iterative subspace approach (r-GDIIS), the modified restricted step rational function optimization method (RS-RFO), and the novel subspace gradient enhanced Kriging method, combined with restricted variance optimization (S-GEK/RVO). The modifications introduced are aimed to improve the robustness and computational scaling of the procedures. In particular, the subspace approach in S-GEK/RVO allows the application to SCF/KS-DFT optimization of a machine technique that has proved successful in geometry optimizations. The performance of the three methods is benchmarked for a large number of small to medium-sized organic molecules, at equilibrium structures and close to a transition state, and a second set of molecules containing closed- and open-shell transition metals. The results indicate the importance of the resetting technique in boosting the performance of the r-GDIIS procedure. Moreover, it is demonstrated that already at the inception of the subspace version of GEK to optimize SCF wave functions, it displays superior and robust convergence properties as compared to standard state-of-the-art SCF/KS-DFT optimization methods.
Copper/photoredox catalysis enables desulfonylative radical N-glycosylation
Authors: Sun Qikai , Wang Quanquan , Qin Wenzhuo , Jiang Kaiyu , He Gang , Koh Ming Joo , Chen Gong
Published: November 2023

The state-of-the-art for glycosylation primarily relies on the classical polar reactions of heteroatomic nucleophiles with electrophilic glycosyl oxocarbenium intermediates. While such an ionic glycosylation strategy has worked well to deliver O-glycosides, its utilization in N-glycoside synthesis is often plagued by the subdued reactivity of N-nucleophiles under the acidic reaction conditions required for activating glycosyl donors. Exploring the reactivity of glycosyl radical intermediates could open up new glycosylation pathways. However, despite the recent significant progress in radical-mediated synthesis of C-glycosides, harnessing the reactivity of glycosyl radicals for the generation of canonical O- or N-glycosides remains elusive. Herein, we report the first examples of glycosyl radical-mediated N-glycosylation reaction using readily accessible glycosyl sulfone donors and N-nucleophiles under mild copper-catalyzed photoredox-promoted conditions. The method is efficient, selective, redox-neutral, and broadly applicable, enabling facile access to a variety of complex N-glycosides and nucleosides in a streamlined fashion. Importantly, the present system tolerates the presence of water and offers unique chemoselectivity, allowing selective reaction of NH sites over hydroxyl groups that would otherwise pose challenges in conventional cationic N-glycosylation.
Halobenzene adducts of a dysprosocenium single-molecule magnet
Authors: Corner Sophie , Gransbury Gemma , Vitorica-Yrezabal Inigo , Whitehead George , Chilton Nicholas , Mills David
Published: November 2023

Dysprosium complexes with strong axial crystal fields are promising candidates for single-molecule magnets (SMMs), which could be used for high-density data storage. Isolated dysprosocenium cations, [Dy(CpR)2]+ (CpR = substituted cyclopentadienyl), have recently shown magnetic hysteresis (a memory effect) above the temperature of liquid nitrogen. Synthetic efforts have focused on reducing strong transverse ligand fields in these systems, as they are known to enhance magnetic relaxation by spin-phonon mechanisms. Here we show that equatorial coordination of the halobenzenes PhX (X = F, Cl, Br) and o-C6H4F2 to the cation of a recently reported dysprosocenium complex [Dy(Cpttt)(Cp*)][Al{OC(CF3)3}4] (Cpttt = C5H2tBu3-1,2,4; Cp* = C5Me5) reduces magnetic hysteresis temperatures compared to the parent cation. We find that this is due to increased effectiveness of both one- (Orbach) and two-phonon (Raman) relaxation mechanisms, which correlate with the electronegativity and number of interactions with the halide. We observe unusual divergent behavior of relaxation rates at low temperature in [Dy(Cpttt)(Cp*)(PhX)][Al{OC(CF3)3}4], which we attribute to a phonon bottleneck effect. We find that, despite the transverse fields introduced by the monohalobenzenes in these cations, the interactions are sufficiently weak that the effective barriers to magnetization reversal remain above 1000 cm–1, being only ca. 100 cm–1 lower than the parent complex, [Dy(Cpttt)(Cp*)][Al{OC(CF3)3}4].
Isonitriles as Alkyl Radical Precursors in Visible-Light Mediated Hydro– and Deuterodeamination Reactions
Authors: Quiros Irene , Martin Maria , Gomez-Mendoza Miguel , Cabrera-Afonso Maria Jesus , Liras Marta , Fernandez Israel , Novoa Luis , Tortosa Mariola
Published: November 2023

Herein, we report the use of isonitriles as alkyl radical precursors in light-mediated hydro- and deuterodeamination reactions. The reaction is scalable, shows broad functional group compatibility and potential to be used in late-stage functionalization. Importantly, the method is general for Cα-1º, Cα-2º and Cα-3º alkyl isonitriles. For most examples, high yields were obtained through direct visible-light irradiation of the isonitrile in the presence of a silyl radical precursor. Interestingly, in the presence of an organic photocatalyst (4CzIPN) a dramatic acceleration was observed. In depth mechanistic studies using UV-vis absorption, steady-state and time-resolved photoluminescence, and transient absorption spectroscopy suggest that the excited state of 4CzIPN is able to sensitize the isonitrile through a single electron transfer.
Electrochemical NO Generation: Past, Present, and Future
Authors: Pung Michael , Jolly Brandon , Liu Chong
Published: November 2023

Generation of NO is crucial for many biological applications due to the antiseptic and antithrombotic properties of NO, as well as its role as a signaling molecule. Much work has been devoted to developing various methods of generating NO on demand. Recently, temporal control and fine-tunability have become highly sought after in NO generation, wherein electrochemistry has emerged as a suitable approach. Herein, we give an overview of the progress towards developing electrochemical generation of NO thus far and offer an outlook for the future of the field. Since much of electrochemical NO generation involves the use of either organometallic catalysts or catalysts inspired by enzymes, addressing challenges and limitations in electrochemical NO generation warrant collaboration between electrochemistry, organometallics, materials, and biochemistry. While the combination of electrochemistry with organometallics currently uses Cu and Fe-based catalysts, there is inspiration to discover other transition metal-based catalysts. Additionally, the combination of electrochemistry with advanced materials could result in the use of nanostructured electrodes such as nanowires and nanorods. These combinations with biochemistry allows for on demand NO generation systems to be developed in a biocompatible manner. In particular, the above propositions are taken from the well-studied CO2 reduction to CO, due to the similarities with nitrite (NO2–) reduction, which is a common NO precursor.
Developing Cheap but Useful Machine Learning based Models for Investigating High-Entropy Alloy Catalysts
Authors: Sun Chenghan , Goel Rajat , Kulkarni Ambarish
Published: November 2023

This work aims to address the challenge of developing interpretable ML-based models when access to large scale computational resources is limited. Using CoMoFeNiCu high-entropy alloy catalysts as an example, we present a cost-effective workflow that synergistically combines descriptor based approaches, machine learning based force fields and low-cost density functional theory (DFT) calculations to predict high-quality adsorption energies for H, N and NHx (x = 1, 2 and 3) adsorbates. This is achieved using three specific modifications to typical DFT workflows including, (1) using a sequential optimization protocol, (2) developing a new-geometry based descriptor, and (3) re-purposing the already-available low-cost DFT optimization trajectories to develop a ML-FF. Taken together, this study illustrates how cheap DFT calculations and appropriately designed descriptors can be used to develop cheap but useful models for predicting high-quality adsorption energies at significantly lower computational costs. We anticipate that this resource-efficient philosophy may be broadly relevant to the larger surface catalysis community.
Intrinsic deletion at 10q23.31, including thePTENgene locus, is aggravated upon CRISPR-Cas9–mediated genome engineering in HAP1 cells mimicking cancer profiles
Authors: Geng Keyi , Merino Lara G , Veiga Raül G , Sommerauer Christian , Epperlein Janine , Brinkman Eva K , Kutter Claudia
Published: November 2023

The CRISPR-Cas9 system is a powerful tool for studying gene functions and holds potential for disease treatment. However, precise genome editing requires thorough assessments to minimize unintended on- and off-target effects. Here, we report an unexpected 283-kb deletion on Chromosome 10 (10q23.31) in chronic myelogenous leukemia-derived HAP1 cells, which are frequently used in CRISPR screens. The deleted region encodes regulatory genes, includingPAPSS2,ATAD1,KLLN, andPTEN. We found that this deletion was not a direct consequence of CRISPR-Cas9 off-targeting but rather occurred frequently during the generation of CRISPR-Cas9–modified cells. The deletion was associated with global changes in histone acetylation and gene expression, affecting fundamental cellular processes such as cell cycle and DNA replication. We detected this deletion in cancer patient genomes. As in HAP1 cells, the deletion contributed to similar gene expression patterns among cancer patients despite interindividual differences. Our findings suggest that the unintended deletion of 10q23.31 can confound CRISPR-Cas9 studies and underscore the importance to assess unintended genomic changes in CRISPR-Cas9–modified cells, which could impact cancer research.
Mitochondrial phosphoproteomes are functionally specialized across tissues
Authors: Hansen Fynn M , Kremer Laura S , Karayel Ozge , Bludau Isabell , Larsson Nils-Göran , Kühl Inge , Mann Matthias
Published: November 2023

Mitochondria are essential organelles whose dysfunction causes human pathologies that often manifest in a tissue-specific manner. Accordingly, mitochondrial fitness depends on versatile proteomes specialized to meet diverse tissue-specific requirements. Increasing evidence suggests that phosphorylation may play an important role in regulating tissue-specific mitochondrial functions and pathophysiology. Building on recent advances in mass spectrometry (MS)-based proteomics, we here quantitatively profile mitochondrial tissue proteomes along with their matching phosphoproteomes. We isolated mitochondria from mouse heart, skeletal muscle, brown adipose tissue, kidney, liver, brain, and spleen by differential centrifugation followed by separation on Percoll gradients and performed high-resolution MS analysis of the proteomes and phosphoproteomes. This in-depth map substantially quantifies known and predicted mitochondrial proteins and provides a resource of core and tissue-specific mitochondrial proteins (mitophos.de). Predicting kinase substrate associations for different mitochondrial compartments indicates tissue-specific regulation at the phosphoproteome level. Illustrating the functional value of our resource, we reproduce mitochondrial phosphorylation events on dynamin-related protein 1 responsible for its mitochondrial recruitment and fission initiation and describe phosphorylation clusters on MIGA2 linked to mitochondrial fusion.
An evaluation of fetal heart monitoring during labour for low-risk women in Samoa (Upolu)
Authors:   , Tofaeono Fueta'ai Mele
Published: November 2023

Fetal heart monitoring (FHM) is an essential midwifery skill to determine fetal well-being and maternal characteristics during labour. Intermittent auscultation (IA) and Cardiotocography (CTG) are the two ways to perform fetal heart monitoring. IA is the suitable method to carry out fetal heart monitoring of low-risk women during labour, however, in Samoa, availability of resources (equipment and staff) in each hospital facilities influence fetal heart monitoring practice.

This research set out to explore the level of the clinical problem in Samoa. Informed by the science of Knowledge Translation, a sequential mixed methods observational study was employed to explore the research questions. This involved a medical record review at three Hospitals in Upolu, and semi structured interviews with midwives working in the same Hospitals.

Based on the findings, fetal heart monitoring is poorly translated into practice. Documentation of intermittent auscultation (duration, frequency, timing) in the first and second stage of labour was inadequate, and access to fetal heart monitoring equipment (Pinard stethoscope, hand-held Doppler devices, and cardiotocograph machines) was unequal in Upolu. The review of medical records indicated that the CTG transducer was utilised to monitor the fetal heart in 75% of cases within the tertiary referral system. On the other hand, the handheld Doppler was only used 14% of the time in two District Hospitals, with no documentation of Pinard usage.

From the interviews with midwives three core themes, 11 subthemes supporting the core themes, and one sub-sub theme emerged. Core themes were ‘Midwives’ knowledge, experiences, views, and practice’; ‘Resources and Risks’; and ‘Protocol and training’. The findings reflected poor translation of knowledge of intrapartum fetal heart monitoring for low-risk women.

This study is significant as it is the first of its kind to examine intrapartum fetal heart monitoring practices in the Pacific islands and sheds light on the knowledge, views, practices, and experiences of Samoa Midwives regarding fetal heart monitoring. The results of this study can contribute to research knowledge, influence important changes in midwifery care, and potentially improve maternal and neonatal outcomes in Samoa and the wider Pacific region.
Construcciones hñähñu de piedra en Hidalgo, México
Authors: Velázquez-Martínez Nancy , Guerrero-Baca Luis F.
Published: November 2023

El presente artículo se centra en el análisis de un tipo de bienes culturales que tiene un elevado valor patrimonial, pero que se encuentra en riesgo de desaparecer. Se trata de construcciones vernáculas de piedra de origen hñähñu que aún perviven y que han sido escasamente estudiadas. Estas obras se localizan en la comunidad de Juchitlán, Tasquillo, Hidalgo y gracias a los relatos de informantes clave, se documenta información importante sobre su origen y proceso constructivo.
Diseño de elementos de protección solar para fachadas acristaladas como mejora al confort térmico: caso estudio en la ciudad de Mexicali, Baja California
Authors: Santamaría-Villa Gerardo , Bigurra-Alzati Carlos Alfredo , Luna-León Aníbal
Published: November 2023

Las ciudades de clima cálido muy seco como Mexicali, Baja California, alcanzan temperaturas muy altas en verano y muy bajas en invierno, lo que demanda el uso desmedido de climatización para mantener los espacios confortables. El propósito de este estudio es evaluar la propuesta de diseño de un elemento de protección solar basado en la trayectoria del sol para ser aplicado en dicha ciudad, con el fin de mejorar las condiciones de confort térmico en el interior de los espacios y de este modo, permitir la climatización pasiva y obtener reducciones de carga térmica que aporten un beneficio energético. Se utilizó un modelo base con orientación sur, bajo un esquema metodológico de tipo cuantitativo con análisis causa-efecto, por medio de simulación mediante EnergyPlus, que hace énfasis en el uso de modelos y analogías. Así mismo, el periodo de análisis se realizó durante un año, equiparando los resultados con – sin los elementos de protección solar. Los resultados muestran que la aplicación de los elementos de protección solar permite una disminución de la temperatura operativa al interior del modelo base y una mayor cantidad de horas de confort térmico, así como una disminución de consumo energético.
Algoritmo de optimización metaheurístico inspirado en el autómata celular LIFE
Authors: López-Arias Omar , Seck-Tuoh-Mora Juan Carlos , Hernández-Romero Norberto , Medina-Marín Joselito , Juárez Martínez Genaro
Published: November 2023

Debido a que existe gran variedad de problemas de optimización, surgió la idea de diseñar un nuevo método inspirado en el comportamiento dinámico de los autómatas celulares. Para ello, se adaptan las reglas de evolución de un conocido autómata celular llamado “El juego de la vida o LIFE”. Estas reglas se implementaron con vectores de valores reales, de esta manera se realizan las acciones de exploración y explotación en el proceso de optimización global. El algoritmo se probó mediante un estudio comparativo utilizando una metaheurística reconocida por su rendimiento y de reciente publicación. Esta metaheurística se denomina: Algoritmo de autómatas celulares de estado continuo (CCAA, por sus siglas en inglés). Para el estudio se utilizaron librerías de funciones de prueba reconocidas por la comunidad científica para evaluar su comportamiento. Se comprobó mediante la comparación de los resultados obtenidos entre ambos algoritmos que la propuesta LIFE fue capaz de competir y, en algunos casos, mejorar la solución buscada. Se concluye que las reglas propuestas tienen un grado de eficiencia muy aceptable con el algoritmo comparado.
Tratamiento de aguas grises para viviendas de interés social popular
Authors: Bautista-Gómez Marcos Irán , Rodríguez-Reyes Diego Alberto , Castañeda-Robles Iván Erick , González-Sandoval María del Refugio , Escalante-Lozano Jonathan Enrique
Published: November 2023

El estrés hídrico continúa en aumento alrededor del mundo, ya que cada vez se cuenta con un menor volumen de agua de calidad para consumo humano. En el centro México, donde se ubica el Estado de Hidalgo, la disponibilidad de agua per cápita es menor a 2000 m3/hab/año. En este estudio exploratorio, se propone un sistema de filtración de aguas grises para su reúso en actividades domésticas, para el municipio de Mineral de la Reforma, Hidalgo. El sistema, planteado es para una vivienda de interés social popular de un nivel, con una capacidad máxima de 4 personas. Se integró como filtros en serie, con distintos medios materiales pétreos naturales y plantas de ornato. El afluente y efluente fueron analizados, obteniéndose resultados favorables, reduciendo la demanda química de oxígeno en un 77.6%, por lo que podría utilizarse para riego y limpieza, constituyendo un ahorro en el consumo de agua potable de manera continua.
Aplicación de herramientas de gestión de calidad en una empresa de cárnicos
Authors: Juárez-Jiménez Karen Yessenia , Licona-Olmos Jazmin Georgina , Serrano-Serrano Arturo
Published: November 2023

Este artículo tiene como objetivo seleccionar las alternativas optimas de solución de la problemática que enfrenta una empresa dedicada a la venta de cárnicos con base en la aplicación de herramientas de gestión de calidad para la contribución en la reducción de costos constantemente. Cabe resaltar que después de una búsqueda bibliográfica no se encontraron trabajos similares en empresas de este giro, razón por la cual es innovador este trabajo. En el cual de aplicó la mejora continua, por ello se describen herramienta de gestión de la calidad como: el diagrama de Ishikawa, diagrama de Pareto, gráficos de control, gráficos estadísticos, entre otros que ayudaron a proponer y evaluar diversas alternativas.
Filosofía de las ciencias en la ingeniería. Una disertación base para el desarrollo humano y organizacional
Authors: Ortega-Reyes Antonio Oswaldo
Published: November 2023

En el contexto del siglo XXI, marcado por avances tecnológicos como la inteligencia artificial, la computación cuántica y las telecomunicaciones 5G, surge la pregunta sobre la relación entre la filosofía y la industria. A pesar de parecer innecesario, se argumenta que la filosofía de las ciencias en la ingeniería tiene un papel importante en el sincretismo entre ambas disciplinas. Aunque en sus etapas iniciales, esta doctrina busca explorar cómo la filosofía influye en la comprensión del universo, la sociedad y la cultura. Se señala que la filosofía es la cuna del pensamiento moderno occidental, donde diversos pensadores han analizado fenómenos naturales y cuestiones humanas. Las organizaciones y sectores de la sociedad, incluidas las empresas, reflejan los valores y principios filosóficos en su estructura. El artículo plantea cuestionamientos sobre el nivel de conciencia de las personas respecto a esta influencia y si los profesionales de la ingeniería son conscientes de su aplicación. El artículo busca establecer un antecedente en esta discusión.
A (IN)CONSTITUCIONALIDADE DA CONFISSÃO DO INVESTIGADO NO ACORDO DE NÃO PERSECUÇÃO PENAL BRASILEIRO
Authors:   , Pires Steffany Gilmara Rodrigues
Published: November 2023

O acordo de não persecução penal foi introduzido pela lei 13.964/2019 no Código de Processo Penal em seu Art. 28-A sendo um acordo que beneficia a justiça negocial no Brasil. Entretanto, para o indivíduo ser favorecido com o acordo de não persecução penal ele deve confessar a pratica do crime para o Ministério Público, contudo a prática da confissão se torna materialmente inconstitucional com base no princípio da não auto incriminação e a Convenção de Direitos Humanos. A presente pesquisa foi feita a partir de métodos bibliográfico que irá mostrar a evolução histórica brasileira no judiciário e como decorre a inconstitucionalidade material da confissão.
POBREZA MENSTRUAL A Dignidade Menstrual como Direito Humano: Ainda não respeitado no Brasil.
Authors: Silva Fernanda Pereira Rosario da
Published: November 2023

Resumo: Este artigo científico tem como objetivo abordar a pobreza menstrual, tema este vivenciado pelas meninas, mulheres, homens trans e pessoas não binárias que menstruam, e aponta um acesso desigual a direitos e oportunidades, o que contribui para retroalimentar os ciclos transgeracionais de inequidades de gênero, raça, classe social, além de impactar negativamente a trajetória educacional e profissional destas pessoas, problema este que atinge uma parcela significativa da população brasileira, que vive abaixo da linha da pobreza, ou em situação de hipervulnerabilidade, os impactos são alarmantes, e sua permanência representa uma afronta direta, ao princípio da dignidade da pessoa humana, fundamento este constitucional do Estado Democrático de Direito.

Astratto: Questo articolo scientifico mira ad affrontare la povertà mestruale, un tema vissuto da ragazze, donne, uomini trans e persone non binarie che hanno le mestruazioni, e mette in evidenza la disparità di accesso ai diritti e alle opportunità, che contribuisce a alimentare i cicli transgenerazionali delle disuguaglianze di genere. , razza , classe sociale, oltre ad avere un impatto negativo sul percorso educativo e professionale di queste persone, problema che colpisce una parte significativa della popolazione brasiliana, che vive al di sotto della soglia di povertà, o in una situazione di ipervulnerabilità, gli impatti sono allarmanti, e la loro permanenza rappresenta un affronto diretto al principio della dignità umana, che è il fondamento costituzionale dello Stato di diritto democrático.
EMPREGO DA MADEIRA NA CONSTRUÇÃO CIVIL: ANÁLISE DO GERENCIAMENTO DE RESÍDUOS EM UMA RESIDÊNCIA MULTIFAMILIAR
Authors: Dorr Felipe , Pinto Rafael Villanova , Souza Willian de
Published: November 2023

A utilização da madeira como material de construção tem se mostrado
cada vez mais relevante, tanto pela sua versatilidade quanto pela sua perenidade.
Nesse contexto, o presente artigo tem como objetivo analisar a destinação final dada
à madeira em uma obra de construção civil, especificamente em uma residência
multifamiliar de duas unidades com um total de 312m², e discutir a importância do
gerenciamento de resíduos nesse processo. Para alcançar esse objetivo, a
metodologia empregada envolveu a revisão bibliográfica sobre o uso da madeira na
construção civil e o gerenciamento de resíduos, além de uma análise dos resultados
da obra em questão. Os resultados obtidos mostraram que o gerenciamento
adequado de resíduos é essencial para garantir a sustentabilidade da construção civil
e a preservação do meio ambiente, dado que a madeira pode ser reaproveitada em
diversas fases da construção, como na elaboração de fôrmas para concreto.
Teoria de Vygotsky e suas contribuições para os processos de aprendizagem no ensino da matemática.
Authors: Martins Lorena de Pontes
Published: November 2023

Neste artigo buscou-se elaborar um estudo direcionado sobre os pontos substanciais da Teoria de Vygotsky aplicáveis no processo de ensino e aprendizagem de matemática, com o objetivo de refletir e talvez aprimorar as discussões em torno dessa teoria e suas contribuições no processo de aprendizagem dos estudantes, com a pretensão de contribuir na construção de melhorar o processo de ensino e aprendizagem da matemática.
Para Vygotsky, o homem é considerado como um ser histórico-cultural e como agente de transformação do meio em que vive. E nesse contexto surgem os principais conceitos que norteiam a obra de Vygotsky, e que são estudados neste artigo objetivando o processo de ensino e aprendizagem são eles: a Mediação, a Interação Social e a Zona de Desenvolvimento Proximal, na teoria de Vygotsky esses conceitos carregam a proposta da contextualização do saber sistematizado a partir das vivências de cada estudante busca conhecer a realidade prática individual e coletiva responsáveis pelos conhecimentos que cada estudante já possui e traz para a escola, considera esse conhecimento uma espécie de material escolar peculiar do estudante, que deve ser utilizado com a mediação do professor no processo de ensino e aprendizagem da matemática um saber sistematizado construído historicamente, objetivando-se, ao fim, a conversão desses estudantes em agentes capazes de aprender e também desenvolver-se mentalmente.
O artigo enfatiza a utilização de procedimentos presentes na teoria de Vygotsky que envolvem a problematização e a instrumentalização teórico-prática onde os estudantes, com a mediação do professor, podem avançar no processo de aprendizagem e desenvolvimento mental na ambiente escolar, contribuindo no processo de construção do ensino da matemática nas escolas. Para Vygotsky o processo de aprendizagem passa pelas relações sociais, com a participação de uma mediação através de instrumentos e ou signos, para tanto o professor desempenha papel importante no processo da aprendizagem e do desenvolvimento mental do estudante, bem como a escola como espaço de aprendizagem. O conceito de Zona de Desenvolvimento Proximal presente na teoria de Vygotsky, deixa evidente que o bom ensino é aquele que estimula a criança a atingir um nível de compreensão e habilidade que ainda não domina completamente. “O bom aprendizado é aquele que se adianta ao desenvolvimento” Vygotsky (1991, p. 101). Ou seja, quando o aprendizado escolar eleva o nível mental de desenvolvimento em relação à sua idade cronológica.
El pensar histórico como dimensión del conocimiento
Authors: Granja Castro Josefina
Published: November 2023

Este trabajo propone una reflexión sobre la historia no a partir de su carácter disciplinario (sus métodos, teorías, problemas), sino a través de lo que aquí se plantea en términos del “pensar histórico” entendido como forma particular de encarar los diversos ámbitos de la sociedad que toma como guía de observación los procesos de emergencia, desarrollo y cambio de los discursos y prácticas. Desde la segunda mitad del siglo XX se ha venido insistiendo en la naturaleza transdisciplinaria y multirreferenciada del conocimiento social. El modelo de disciplinas como cajones de anaquel se ha tornado obsoleto ya hora pensamos más en términos de problemas y redes en vez de objetos y disciplinas. En ese sentido, el pensar histórico admite ser considerado como una dimensión del conocimiento válida en la indagación de todo proceso de la vida social.
Assess the maternal factors associated with Birth weight of newborn
Authors: Deepika Wanode  , Amar Yadav
Published: November 2023

An exploratory study was conducted to assess maternal factors associated with Birth Weight of newborn in selected Hospital, Indore. A total of 50 antenatal mothers were selected through convenient sampling technique. An interview schedule was conducted using structured questionnaire to collect the data. Content validity of the tools determined by an expert. Both descriptive and inferential statistics were used for data analysis. The results of current study reveals that there were significant association found between Maternal factors like Monthly income of the family, weight gain during Pregnancy, Hemoglobin level of the mother, Total No. of ANC visits, anemia with birth weight of newborns. There is no significant association found among other factors. Study concluded that maternal factors (Socio demographic Variables, General Health Assessment, Obstetric History, Medical Ailments during Pregnancy, Nutritional Assessment) can affect the weight of the babies.
An update of Seroprevalence of HBV among healthcare workers in Yemen: a review of data published between 2001 and 2020
Authors: Fahd A.A. Al-Romima  , Adam Hezam Faed Al-Shamiri  , Ashwaq Ahmed Abdullah
Published: November 2023

Hepatitis B virus (HBV) infection is a major global health problem. Healthcare workers (HCWs) are at high risk of HBV infection. The aim of this review was to summarize HBV seroprevalence in HCWs in Yemen. Electronic databases (PubMed, Google Scholar, and Google) had been used to search for studies on HBV seroprevalence in HCWs in Yemen. Among 1119 HCWS seem in this review, 78 (6.97%) were seropositive for HBV infection. HBV infection correlated significantly with HCWs. HCWs (2.76%-21.4%) infected with HBV. HCWs in Yemen are considered at moderate to high risk of HBV infection according to WHO classification. The prevalence of HBV infection in recent years decreased compared with that published during 2001-2004.
Liquid organic fertilizer availability and utilization in Nigeria: A review
Authors: ENEMALI S.I  , ALFA J  , YUSUF O.Y  , MUAZU I
Published: November 2023

The word as in general has the responsibility to respond to the emerging food crisis to match the growing population. Africa and many other Low Income Countries under Stress [LICUS] will face a stiffer challenge. Africa and specifically Sub-Saharan Africa depends much on synthetic fertilizers with disease burden. The concept and awareness of Organic Fertilizer and its Utilization in Agro farming with attendant benefits in Nigeria is at its lowest ebb. This review highlighting availability, of Liquid Organic Fertilizer in Nigeria agro-allied market among farmers and the awareness/benefits in Organic farming reveals much on the scale of 10. 1-3 reliable fertilizers companies are visible with most emphasis on synthetic fertilizer blending only. 1-2 reliable fertilizer company manufactures urea and synthetic fertilizer from which other companies get involved in the distribution. 1-2 claimed that their fertilizers are purely organic in powdered sachet forms. 1-3 claimed to produce liquid organic fertilizer alongside synthetic fertilizer formulation. 1-2 notable liquid organic fertilizers available claimed foliar mode of application. 2 out of 10 makes use of solid human wastes for liquid organic fertilizer. 5 out of 10 liquid organic fertilizer were found to be compost in nature while 2 out of 10 claimed to be organic liquid in nature. 1 3 Liquid Organic Fertilizers encountered cannot be verified by literature on their composition, materials and process of production. The available liquid organic fertilizer in Nigeria is with mixed acceptance. Synthetic fertilizer manufacturers claimed that their products can be used as organic fertilizer. Droppings from animal waste claimed their products are manures and fertilizers. Other liquid organic fertilizer companies claimed use of sea weeds without clear mechanism of actions. Nevertheless, a liquid fertilizer company located in Kuje, Abuja has been identified to possess state of art product line facilities with purely organic materials as source.
Intention to use digital transformation of human resource employees in Hanoi
Authors: Nguyen Thi Linh  , Tran Thi Thu Ha
Published: November 2023

Digital transformation is at the heart of the fourth industrial revolution, which leads to fundamental and far-reaching changes in business operations. In an environment where all fields and industries are undergoing digital transformation, are human resources employees willing to accept and implement digitalization in their daily work, and what factors influence their intention to use digitalization in their work? The article studies 130 human resources staff at businesses in the Hanoi area. Research results confirm that perceived usefulness, perceived ease of use, and perceived self-efficacy about digital transformation have a positive influence on human resources employees' intentions to use digital transformation at work. For human resources staff to be comfortable in the process of using technology in a digital transformation environment, human resources employees need to be guided and trained on how to apply new applications and new technology in the field of human resources.