bluuebunny/crossref_metadata_2025 huggingface dataset:
A Coding Theorem for f-Separable Distortion Measures
Authors: Shkel Yanina , Verdú Sergio
Published: February 2018

In this work we relax the usual separability assumption made in rate-distortion literature and propose f -separable distortion measures, which are well suited to model non-linear penalties. The main insight behind f -separable distortion measures is to define an n-letter distortion measure to be an f -mean of single-letter distortions. We prove a rate-distortion coding theorem for stationary ergodic sources with f -separable distortion measures, and provide some illustrative examples of the resulting rate-distortion functions. Finally, we discuss connections between f -separable distortion measures, and the subadditive distortion measure previously proposed in literature.
Miscible CO2 Flooding for EOR in the Presence of Natural Gas Components in Displacing and Displaced Fluids
Authors: Hamouda Aly , Chughtai Sidra
Published: February 2018

Carbon dioxide (CO2) flooding is a complicated process as it involves phase behavior. The objective of this work was to understand the mass transfer mechanisms during flooding with CO2 and CO2/C1/C3 (CO2/HC) based on experimental and simulated composition changes. Three model oil compositions were used (n-C10, n-C10/C1, and n-C10/C1/C3). For a comparison, crude oil from a North Sea field was included. The second part of the investigation was to compare the effect of the combined light components (C1/C3) with CO2 as a displacing fluid on enhanced oil recovery (EOR). Equation of State EOS SRK–Peneloux was used for the simulations to predict composition changes. The highest recovery was obtained from model oil (n-C10) displaced with CO2 compared to model oil containing light components with the highest recovery recorded from model oil/C1 (live oil A) compared to model oil/C1/C3 at all of the tested temperatures. The presence of light components (C1/C3) in the injected CO2 at miscible conditions increased the oil recovery for crude oil compared to flooding only with CO2. Transverse dispersion of CO2 helps in eliminating/reducing the effect of viscous instabilities by shortening fingering travel/widening the fingers. The collected samples contained water, although the flooding was done on dry sandstone cores. Possible mechanisms are discussed in a later section.
Smart Building: Use of the Artificial Neural Network Approach for Indoor Temperature Forecasting
Authors: Attoue Nivine , Shahrour Isam , Younes Rafic
Published: February 2018

The smart building concept aims to use smart technology to reduce energy consumption, as well as to improve comfort conditions and users’ satisfaction. It is based on the use of smart sensors and software to follow both outdoor and indoor conditions for the control of comfort, and security devices for the optimization of energy consumption. This paper presents a data-based model for indoor temperature forecasting, which could be used for the optimization of energy device use. The model is based on an artificial neural network (ANN), which is validated on data recorded in an old building. The novelty of this work consists of the methodology proposed for the development of a simplified model for indoor temperature forecasting. This methodology is based on the selection of pertinent input parameters after a relevance analysis of a large set of input parameters, including solar radiation outdoor temperature history, outdoor humidity, indoor facade temperature, and humidity. It shows that an ANN-based model using outdoor and facade temperature sensors provides good forecasting of indoor temperatures. This model can be easily used in the optimal regulation of buildings’ energy devices.
Dynamic Analysis of a Hybrid Energy Storage System (H-ESS) Coupled to a Photovoltaic (PV) Plant
Authors: Barelli Linda , Bidini Gianni , Bonucci Fabio , Castellini Luca , Castellini Simone , Ottaviano Andrea , Pelosi Dario , Zuccari Alberto
Published: February 2018

Nowadays energy storage is strongly needed to allow grid safety and stability due to the wide penetration of renewable plants. Mainly economic and technological issues impede a relevant integration of conventional storage devices in the energy system. In this scenario, the hybridization of different storage technologies can be a techno-economic solution useful to overcome these issues and promote their diffusion. Hybridization allows multi-operation modes of the Energy Storage System (ESS), merging the positive features of base-technologies and extending their application ranges. This paper provides a dynamic analysis of a hybrid energy storage system (H-ESS) consisting of a flywheel and a battery pack coupled to a photovoltaic generation plant and a residential load up to 20 kW. A dynamic model of the overall micro-grid (MG) was developed implementing the H-ESS preliminary sizing and a suitable management algorithm. The instantaneous behavior of each component was evaluated. A brief summary of the MG performance at different weather and load conditions was provided together with a characterization of the impact of power fluctuations on the battery current and on the power exchange with the grid.
Anti-Agglomerator of Tetra-n-Butyl Ammonium Bromide Hydrate and Its Effect on Hydrate-Based CO2 Capture
Authors: Li Rong , Li Xiao-Sen , Chen Zhao-Yang , Zhang Yu , Xu Chun-Gang , Xia Zhi-Ming
Published: February 2018

Tetra-n-butyl ammonium bromide (TBAB) was widely used in the research fields of cold storage and CO2 hydrate separation due to its high phase change latent heat and thermodynamic promotion for hydrate formation. Agglomeration always occurred in the process of TBAB hydrate generation, which led to the blockage in the pipeline and the separation apparatus. In this work, we screened out a kind of anti-agglomerant that can effectively solve the problem of TBAB hydrate agglomeration. The anti-agglomerant (AA) is composed of 90% cocamidopropyl dimethylamine and 10% glycerol, which can keep TBAB hydrate of 19.3–29.0 wt. % in a stable state of slurry over 72 h. The microscopic observation of the morphology of the TBAB hydrate particles showed that the addition of AA can greatly reduce the size of the TBAB hydrate particles. CO2 gas separation experiments found that the addition of AA led to great improvement on gas storage capacity, CO2 split fraction and separation factor, due to the increasing of contact area between gas phase and hydrate particles. The CO2 split fraction and separation factor with AA addition reached up to 70.3% and 42.8%, respectively.
Deacetylation Followed by Fractionation of Yellow Poplar Sawdust for the Production of Toxicity-Reduced Hemicellulosic Sugar for Ethanol Fermentation
Authors: Kim Seong , Kim Tae , Oh Kyeong
Published: February 2018

In order to produce bioethanol from yellow poplar sawdust without detoxification, deacetylation (mild alkali treatment) was performed with aqueous ammonia solution. To select the optimal conditions, deacetylation was carried out under different conditions: NH4OH loading (2–10% (w/v)) and a solid-to-liquid ratio of 1:4–1:10 at 121 °C for 60 min. In order to assess the effectiveness of deacetylation, fractionation of deacetylated yellow poplar sawdust was performed using dilute acid (H2SO4, 0.5–2.0% (w/v)) at a reaction temperature of 130–150 °C for 10–80 min. The toxicity-reduced hemicellulosic hydrolyzates that were obtained through a two-step treatment at optimized conditions were fermented using Pichia stipitis for ethanol production, without any further detoxification. The maximum ethanol production was 4.84 g/L, corresponding to a theoretical ethanol yield of 82.52%, which is comparable to those of intentionally made hydrolyzates as controls.
Development of a Data-Driven Predictive Model of Supply Air Temperature in an Air-Handling Unit for Conserving Energy
Authors: Hong Goopyo , Kim Byungseon
Published: February 2018

The purpose of this study was to develop a data-driven predictive model that can predict the supply air temperature (SAT) in an air-handling unit (AHU) by using a neural network. A case study was selected, and AHU operational data from December 2015 to November 2016 was collected. A data-driven predictive model was generated through an evolving process that consisted of an initial model, an optimal model, and an adaptive model. In order to develop the optimal model, input variables, the number of neurons and hidden layers, and the period of the training data set were considered. Since AHU data changes over time, an adaptive model, which has the ability to actively cope with constantly changing data, was developed. This adaptive model determined the model with the lowest mean square error (MSE) of the 91 models, which had two hidden layers and sets up a 12-hour test set at every prediction. The adaptive model used recently collected data as training data and utilized the sliding window technique rather than the accumulative data method. Furthermore, additional testing was performed to validate the adaptive model using AHU data from another building. The final adaptive model predicts SAT to a root mean square error (RMSE) of less than 0.6 °C.
The EU ETS and Dynamic Allocation in Phase IV—An Ex-Ante Assessment
Authors: Duscha Vicki
Published: February 2018

Fear of lowering firms’ competitiveness and carbon leakage is the reason for large amounts of allowances in the European Union’s Emissions Trading System (EU ETS) still being allocated for free. At the same time, unadjusted free allocation of allowances in times of economic recession is partly responsible for the large surplus of allowances that has cumulated in the EU ETS and that is lowering prices in the market. For Phase IV, the introduction of dynamic allocation has been proposed to react to significant changes in production, to prevent the accumulation of further surplus on the one hand and to protect installations from severe underallocation on the other. A reserve of about 400 million allowances is planned for that purpose. This paper analyses the demand for certificates from this reserve under different assumptions on production development as well as different design options for Phase IV. The analysis builds on freely available allocation data from Phase III along with projections of production trends from different time periods in the past. In most of the scenarios, the 400 million allowances are sufficient to fulfil demand for allowances from dynamic allocation until at least the second half of Phase IV (often even for the whole of Phase IV). Even though certain aspects analysed are now not fully compatible with the agreed-upon Phase IV revision, the analysis indicates that the amount of allowances foreseen for dynamic allocation is sufficient for Phase IV. In particular the threshold value of 10% that was introduced in the legislation will ensure that the demand of allowances is likely well below the demand found in the different scenarios in this analysis that neglects this threshold value.
Tissue Culture of Corymbia and Eucalyptus
Authors: Trueman Stephen J. , Hung Cao Dinh , Wendling Ivar
Published: February 2018

Eucalypts are among the world’s most widely planted trees, but the productivity of eucalypt plantations is limited by their often-low amenability to true-to-type propagation from cuttings. An alternative approach to cutting propagation is tissue culture, which can be used to micropropagate valuable genotypes rapidly while simultaneously preserving germplasm in vitro. This review describes the use of tissue culture methods such as shoot culture, organogenesis, and somatic embryogenesis for micropropagating eucalypts. This review also discusses the use of cool storage, encapsulation, and cryopreservation methods for preserving eucalypt germplasm and delaying tissue maturation under minimal-growth conditions.
Constructing Masculinity through Genetic Legacies: Family Histories, Y-Chromosomes, and “Viking Identities”
Authors: Scully Marc
Published: February 2018

The contemporary popularity of genetic genealogy has been accompanied by concerns about its potential reifying of identity. This has referred in particular to ethnicity, but also to gender, with fears that looking at the past through the lens of popular genetics reinforces patriarchal views of the family and traditional heteronormative understandings of masculinity and femininity. This study investigates whether such understandings are drawn upon by male participants in a population genetics study. Discursive analysis of 128 responses to a participant motivation survey and 18 follow-up interviews explores how participants construct masculinity when discussing genetics and their own family history. It is argued that while there is some evidence for the “patriarchal” argument, a subtler form of masculine legacy creation and maintenance is the primary narrative.
DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins
Authors: Svane Anne , Soerensen Mette , Lund Jesper , Tan Qihua , Jylhävä Juulia , Wang Yunzhang , Pedersen Nancy , Hägg Sara , Debrabant Birgit , Deary Ian , Christensen Kaare , Christiansen Lene , Hjelmborg Jacob
Published: February 2018

Several studies have linked DNA methylation at individual CpG sites to aging and various diseases. Recent studies have also identified single CpGs whose methylation levels are associated with all-cause mortality. In this study, we perform an epigenome-wide study of the association between CpG methylation and mortality in a population of 435 monozygotic twin pairs from three Danish twin studies. The participants were aged 55–90 at the time of blood sampling and were followed for up to 20 years. We validated our results by comparison with results from a British and a Swedish cohort, as well as results from the literature. We identified 2806 CpG sites associated with mortality (false discovery rate ( FDR ) < 0.05 ), of which 24 had an association p-value below 10 − 7 . This was confirmed by intra-pair comparison controlling for confounding effects. Eight of the 24 top sites could be validated in independent datasets or confirmed by previous studies. For all these eight sites, hypomethylation was associated with poor survival prognosis, and seven showed monozygotic correlations above 35%, indicating a potential moderate to strong heritability, but leaving room for substantial shared or unique environmental effects. We also set up a predictor for mortality using least absolute shrinkage and selection operator (LASSO) regression. The predictor showed good performance on the Danish data under cross-validation, but did not perform very well in independent samples.
Phenotypic and Genotypic Analysis of Antimicrobial Resistance among Listeria monocytogenes Isolated from Australian Food Production Chains
Authors: Wilson Annaleise , Gray Jessica , Chandry P. , Fox Edward
Published: February 2018

The current global crisis of antimicrobial resistance (AMR) among important human bacterial pathogens has been amplified by an increased resistance prevalence. In recent years, a number of studies have reported higher resistance levels among Listeria monocytogenes isolates, which may have implications for treatment of listeriosis infection where resistance to key treatment antimicrobials is noted. This study examined the genotypic and phenotypic AMR patterns of 100 L. monocytogenes isolates originating from food production supplies in Australia and examined this in the context of global population trends. Low levels of resistance were noted to ciprofloxacin (2%) and erythromycin (1%); however, no resistance was observed to penicillin G or tetracycline. Resistance to ciprofloxacin was associated with a mutation in the fepR gene in one isolate; however, no genetic basis for resistance in the other isolate was identified. Resistance to erythromycin was correlated with the presence of the ermB resistance gene. Both resistant isolates belonged to clonal complex 1 (CC1), and analysis of these in the context of global CC1 isolates suggested that they were more similar to isolates from India rather than the other CC1 isolates included in this study. This study provides baseline AMR data for L. monocytogenes isolated in Australia, identifies key genetic markers underlying this resistance, and highlights the need for global molecular surveillance of resistance patterns to maintain control over the potential dissemination of AMR isolates.
Fluid Vents, Flank Instability, and Seafloor Processes along the Submarine Slopes of the Somma-Vesuvius Volcano, Eastern Tyrrhenian Margin
Authors: Passaro Salvatore , Sacchi Marco , Tamburrino Stella , Ventura Guido
Published: February 2018

We report the geomorphological features of the continental shelf of the Gulf of Naples along the submarine slopes of the Somma-Vesuvius volcanic complex. This area is characterized by seafloor morphologies that are related to mantle degassing. Significant phenomena associated with this process occur. Doming of the seafloor has been detected in the area of Banco della Montagna, whereas a hole-like morphology has formed at Bocca dei Pescatori, likely as a result of a phreatic explosion. Outcropping or partially submerged volcanic bodies are also present as well as two main debris avalanche deposits arising from the main Somma-Vesuvius edifice. A large area characterized by an overall concave external profile and a global sediment wave morphology covers most of the southwestern area of the volcano.
Late Pleistocene Post-Glacial Sea Level Rise and Differential Preservation of Transgressive “Sand Ridge” Deposits in the Adriatic Sea
Authors: Ridente Domenico
Published: February 2018

Linear sand bodies with ridged or mounded morphology are commonly referred to as “sand ridges”. Their origin may reflect a great variety of depositional processes and environments, although many examples from modern shelves include near-shore transgressive deposits formed during the last post-glacial sea level rise. These transgressive sand ridges, however, are not present on all the margins drowned during this interval, indicating that local environmental factors contribute to their formation and preservation. Transgressive sand ridges are recognized on the South Adriatic shelf in water depths between 90 and 120 m, where they overlay a major unconformity originated during the last glacial sea level fall and lowstand. In contrast, they are absent on the Central Adriatic shelf, where transgressive deposits above the glacial unconformity fill erosional scours without forming relief on the seafloor. The transgressive sand ridges on the South Adriatic shelf appear roughly elongated parallel to the bathymetric contour and are locally as thick as 15–20 m. Core data indicate an overall coarse-grained composition, with a relevant bioclastic component. Their limited distribution reflects the importance of local variation in shelf morphology and sediment sourcing at the onset of sea level rise. In particular, their deposition and preservation are favored in less subsiding shelf sectors characterized by higher gradients and tectonic relief, where transgressive erosion and reworking of pre-existing lowstand deposits is also more efficient.
Active Tectonics along the South East Offshore Margin of Mt. Etna: New Insights from High-Resolution Seismic Profiles
Authors: Barreca Giovanni , Corradino Marta , Monaco Carmelo , Pepe Fabrizio
Published: February 2018

The offshore margin of Mt. Etna has been shaped by Middle Pleistocene to Holocene shortening and extension and, more recently, by gravity-related sliding of the volcanic edifice. These processes have acted contemporaneously although the gravitational component largely prevails over the tectonic one. In order to investigate this issue, we focused on the main role of active tectonics along the south-eastern offshore of Mt. Etna by means of marine high-resolution seismic data. Seismic profiles revealed post-220 ka sedimentary deposits unconformably overlaying the Lower-Middle Pleistocene Etnean clayey substratum and volcanics of the Basal Tholeiitic phase and the Timpe phase. Offshore Aci Trezza-Catania, the architecture of the sedimentary deposits reflects syn-tectonic deposition occurred into “piggy-back” basin setting. Shortening rate was estimated at ~0.5 mm/a since ~220 ka. Asymmetric folding also involves post Last Glacial Maximum deposits, evidencing that compressional deformation is still active. In the continental slope, a belt of normal faults offset the Lower-Middle Pleistocene Etnean clayey substratum and younger deposits, also producing seafloor ruptures. Thrust and fold structures can be related to the recent migration of the Sicilian chain front, while extensional faults are interpreted as part of a major tectonic boundary located in the Ionian offshore of Sicily.
The Nippon Foundation—GEBCO Seabed 2030 Project: The Quest to See the World’s Oceans Completely Mapped by 2030
Authors: Mayer Larry , Jakobsson Martin , Allen Graham , Dorschel Boris , Falconer Robin , Ferrini Vicki , Lamarche Geoffroy , Snaith Helen , Weatherall Pauline
Published: February 2018

Despite many of years of mapping effort, only a small fraction of the world ocean’s seafloor has been sampled for depth, greatly limiting our ability to explore and understand critical ocean and seafloor processes. Recognizing this poor state of our knowledge of ocean depths and the critical role such knowledge plays in understanding and maintaining our planet, GEBCO and the Nippon Foundation have joined forces to establish the Nippon Foundation GEBCO Seabed 2030 Project, an international effort with the objective of facilitating the complete mapping of the world ocean by 2030. The Seabed 2030 Project will establish globally distributed regional data assembly and coordination centers (RDACCs) that will identify existing data from their assigned regions that are not currently in publicly available databases and seek to make these data available. They will develop protocols for data collection (including resolution goals) and common software and other tools to assemble and attribute appropriate metadata as they assimilate regional grids using standardized techniques. A Global Data Assembly and Coordination Center (GDACC) will integrate the regional grids into a global grid and distribute to users world-wide. The GDACC will also act as the central focal point for the coordination of common data standards and processing tools as well as the outreach coordinator for Seabed 2030 efforts. The GDACC and RDACCs will collaborate with existing data centers and bathymetric compilation efforts. Finally, the Nippon Foundation GEBCO Seabed 2030 Project will encourage and help coordinate and track new survey efforts and facilitate the development of new and innovative technologies that can increase the efficiency of seafloor mapping and thus make the ambitious goals of Seabed 2030 more likely to be achieved.
Behaviour of Metals during Bioheap Leaching at the Talvivaara Mine, Finland
Authors: Tuovinen Hanna , Pelkonen Mila , Lempinen Janne , Pohjolainen Esa , Read David , Solatie Dina , Lehto Jukka
Published: February 2018

Abstract: The behaviour of base metals Ni, Zn, Cu, Co, Fe, and Mn, potentially toxic metals Pb, Cr, and Cd, and the radioactive elements, U and Th, in the Talvivaara mining process, Finland has been studied by tracing metal concentrations from the black schist ore, through ores subjected to bioheap leaching of varying duration, to pregnant leach solution (PLS), and solid process waste material deposited on site in gypsum waste ponds. It is apparent that Zn, Cu, Co, and Cd are leached from the ore in a similar manner and recovered efficiently in the PLS; however, Ni, though leached, was also found in the gypsum pond at relatively high concentrations. Relatively little Pb is released from the ore, but the small fraction that is mobilised accumulates in the gypsum pond. Of the radioactive constituents, Th is essentially immobile, whereas U is readily leached from the ore, again accumulating in gypsum pond waste. In addition, a laboratory-based sequential leach test was applied to assess the future leaching potential of metals from residual ore and process waste material under different environmental conditions.
Out of Time, Out of Space, Out of Species: Deictic Displacement of the Exiled Self in Hans Sahl’s “Der Maulwurf” (The Mole)
Authors: Swiderski Carla
Published: February 2018

In Hans Sahl’s poem “Der Maulwurf” (The Mole), only the title gives an indication about the speaker’s species affiliation. The speaker of the poem suggests that he was transformed from a human into an animal. This metamorphosis is not only physical, but also seems to have had an impact on the position of the speaker regarding his position in time and space. In this article, I analyze temporal, spatial, and physiological changes in the poem, and I argue that they are indicative of a theme of displacement that is embodied in animal existence in the text. Specifically, these shifts construct an exiled lyric identity whose transformation from human to animal creates an experience of displacement on every pane of existence.
Early Probe and Drug Discovery in Academia: A Minireview
Authors: Roy Anuradha
Published: February 2018

Drug discovery encompasses processes ranging from target selection and validation to the selection of a development candidate. While comprehensive drug discovery work flows are implemented predominantly in the big pharma domain, early discovery focus in academia serves to identify probe molecules that can serve as tools to study targets or pathways. Despite differences in the ultimate goals of the private and academic sectors, the same basic principles define the best practices in early discovery research. A successful early discovery program is built on strong target definition and validation using a diverse set of biochemical and cell-based assays with functional relevance to the biological system being studied. The chemicals identified as hits undergo extensive scaffold optimization and are characterized for their target specificity and off-target effects in in vitro and in animal models. While the active compounds from screening campaigns pass through highly stringent chemical and Absorption, Distribution, Metabolism, and Excretion (ADME) filters for lead identification, the probe discovery involves limited medicinal chemistry optimization. The goal of probe discovery is identification of a compound with sub-µM activity and reasonable selectivity in the context of the target being studied. The compounds identified from probe discovery can also serve as starting scaffolds for lead optimization studies.
Environmental Intolerance, Symptoms and Disability Among Fertile-Aged Women
Authors: Vuokko Aki , Karvala Kirsi , Lampi Jussi , Keski-Nisula Leea , Pasanen Markku , Voutilainen Raimo , Pekkanen Juha , Sainio Markku
Published: February 2018

The purpose was to study the prevalence of environmental intolerance (EI) and its different manifestations, including behavioral changes and disability. Fertile-aged women (n = 680) of the Kuopio Birth Cohort Study were asked about annoyance to 12 environmental factors, symptoms and behavioral changes. We asked how much the intolerance had disrupted their work, household responsibilities or social life. We chose intolerance attributed to chemicals, indoor molds, and electromagnetic fields to represent typical intolerance entities. Of the respondents, 46% reported annoyance to chemicals, molds, or electromagnetic fields. Thirty-three percent reported symptoms relating to at least one of these three EIs, 18% reported symptoms that included central nervous system symptoms, and 15% reported behavioral changes. Indicating disability, 8.4% reported their experience relating to any of the three EIs as at least “somewhat difficult”, 2.2% “very difficult” or “extremely difficult”, and 0.9% “extremely difficult”. Of the latter 2.2%, all attributed their intolerance to indoor molds, and two thirds also to chemicals. As the number of difficulties increased, the number of organ systems, behavioral changes and overlaps of the three EIs also grew. EI is a heterogeneous phenomenon and its prevalence depends on its definition. The manifestations of EI form a continuum, ranging from annoyance to severe disability.
The Roles of Three Types of Knowledge and Perceived Uncertainty in Explaining Risk Perception, Acceptability, and Self-Protective Response—A Case Study on Endocrine Disrupting Surfactants
Authors: Ho Hien , Watanabe Tsunemi
Published: February 2018

The ubiquitous surfactants nonylphenol (NP) and its ethoxylates (NPEOs), which are known as endocrine disrupters, have appeared in the lists of restricted chemical substances, monitoring programs, and environmental quality standards of many countries due to their adverse effects. Recent studies have reported alarming levels of NP, as the final metabolite of NPEOs, in Vietnamese urban waters, whilst response to this issue is negligible. With the aim of addressing how the public perceives and expects to avoid the risk of endocrine disrupting surfactants (EDSs), the study tested the hypothesized roles of specific knowledge, general knowledge, and perceived uncertainty using structural equation modelling. The findings revealed that different types of knowledge played certain roles in explaining risk perception, risk acceptability, and self-protective response, which are distinguished by experience amongst the public. Evidence of the mediating role that perceived uncertainty may play in the decrease of risk perception and the increase of risk unacceptance has been provided. The insights gained from the study may help answer why the public are in favor of taking non-diet-related self-protective measures rather than changing their dietary habits, which illustrates a comparison with the basis of health belief model. The needs for building cognitive capacity amongst the public, particularly pregnant women and young mothers, and risk communication concerning endocrine disrupting contamination linked to reproductive health are highlighted.
Suicidal Ideation among Youth Living in the Slums of Kampala, Uganda
Authors: Culbreth Rachel , Swahn Monica , Ndetei David , Ametewee Lynnette , Kasirye Rogers
Published: February 2018

The purpose of this study is to examine the factors associated with suicidal ideation among youth living in the slums of Kampala, Uganda. Analyses are based on cross-sectional survey data, collected in 2014, of a convenience sample (n = 1134) of urban service-seeking youth participating in a Uganda Youth Development Link drop-in center. Logistic regression analyses were computed to determine the psychosocial factors associated with suicidal ideation. Among youth participants, 23.54% (n = 266) reported suicidal ideation in the past year. In the multivariable analysis, suicidal ideation was associated with being female (OR: 1.61; 95% CI: 1.15, 2.25), reporting one (OR: 1.51; 95% CI: 1.05, 2.18) or two deceased parents (OR: 1.55; 95% CI: 1.03, 2.35), ever living on the streets (OR: 2.65; 95% CI: 1.86, 3.79), problem drinking (OR: 1.83; 95% CI: 1.19, 2.80), sexually transmitted infection (OR: 1.59; 95% CI: 1.14, 2.21), ever being raped (OR: 1.49; 95% CI: 1.01, 2.20), and experiencing physical child abuse (OR: 2.40; 95% CI: 1.75, 3.27). Our findings underscore many unmet needs in this vulnerable population. However, strategies that specifically seek to address problem drinking—a modifiable risk factor for suicidal ideation—may be particularly warranted in this low-resource setting.
An Experimental Exploration of the Effects of Exposure to Images of Nature on Rumination
Authors: Golding Sarah , Gatersleben Birgitta , Cropley Mark
Published: February 2018

Exposure to natural environments has been shown to have beneficial effects on mood. Rumination is a thinking style associated with negative mood, and sometimes depression, and is characterized by repetitive, intrusive thoughts, often with a negative emotional element. This study investigated whether exposure to nature, operationalized using photographs presented as a slideshow, could aid reduction in levels of state rumination. An experimental, within-between (Time x Condition) participant design was used; participants (n = 58) undertook a presentation task designed to induce rumination and influence mood. Participants were then randomly allocated to either: watch a slideshow of a natural environment, watch a slideshow of an urban environment, or wait patiently with no distractions. Data were collected at baseline, after the presentation, and after the slideshow. Environmental exposure had no effect on levels of rumination or negative mood, but did have a significant effect on levels of positive mood, ‘being away’, and ‘fascination’. Positive mood declined in those who saw the urban slideshow, but remained the same in those who saw the nature slideshow, whilst levels of being away and fascination were highest in those who saw the nature slideshow. This study extends previous restorative environment research by exploring the effects of nature on rumination.
Solid Particle Number Emission Factors of Euro VI Heavy-Duty Vehicles on the Road and in the Laboratory
Authors: Giechaskiel Barouch
Published: February 2018

Particulate matter (PM), and in particular ultrafine particles, have a negative impact on human health. The contribution of vehicle PM emissions to air pollution is typically quantified with emission inventories, which need vehicle emission factors as input. Heavy-duty vehicles, although they represent a small percentage of the vehicle population in nearly every major country, contribute the majority of the on-road PM emissions. However, the published data of modern heavy-duty vehicle emissions are scarce, and for the newest Euro VI technologies, almost non-existent. The main objective of this paper is to present Solid Particle Number (SPN) emission factors from Euro VI heavy-duty vehicles using diesel, Compressed Natural Gas (CNG), or Liquefied Natural Gas (LNG). Urban, rural and motorway (highway) emissions were determined on the road at various European cities using SPN Portable Emission Measurement Systems (PEMS). Additional tests on a heavy-duty chassis dynamometer showed that the solid sub-23 nm fraction, which is not covered at the moment in the European regulation, is high, especially for CNG engines. The significant contribution of regeneration events and the effect of ambient temperature and engine cold-start on particle emissions were also discussed.
A Novel Computational Method for Detecting DNA Methylation Sites with DNA Sequence Information and Physicochemical Properties
Authors: Pan Gaofeng , Jiang Limin , Tang Jijun , Guo Fei
Published: February 2018

DNA methylation is an important biochemical process, and it has a close connection with many types of cancer. Research about DNA methylation can help us to understand the regulation mechanism and epigenetic reprogramming. Therefore, it becomes very important to recognize the methylation sites in the DNA sequence. In the past several decades, many computational methods—especially machine learning methods—have been developed since the high-throughout sequencing technology became widely used in research and industry. In order to accurately identify whether or not a nucleotide residue is methylated under the specific DNA sequence context, we propose a novel method that overcomes the shortcomings of previous methods for predicting methylation sites. We use k-gram, multivariate mutual information, discrete wavelet transform, and pseudo amino acid composition to extract features, and train a sparse Bayesian learning model to do DNA methylation prediction. Five criteria—area under the receiver operating characteristic curve (AUC), Matthew’s correlation coefficient (MCC), accuracy (ACC), sensitivity (SN), and specificity—are used to evaluate the prediction results of our method. On the benchmark dataset, we could reach 0.8632 on AUC, 0.8017 on ACC, 0.5558 on MCC, and 0.7268 on SN. Additionally, the best results on two scBS-seq profiled mouse embryonic stem cells datasets were 0.8896 and 0.9511 by AUC, respectively. When compared with other outstanding methods, our method surpassed them on the accuracy of prediction. The improvement of AUC by our method compared to other methods was at least 0.0399 . For the convenience of other researchers, our code has been uploaded to a file hosting service, and can be downloaded from: https://figshare.com/s/0697b692d802861282d3.
Intestinal Permeability and Cellular Antioxidant Activity of Phenolic Compounds from Mango (Mangifera indica cv. Ataulfo) Peels
Authors: Pacheco-Ordaz Ramón , Antunes-Ricardo Marilena , Gutiérrez-Uribe Janet , González-Aguilar Gustavo
Published: February 2018

Mango (Mangifera indica cv. Ataulfo) peel contains bound phenolics that may be released by alkaline or acid hydrolysis and may be converted into less complex molecules. Free phenolics from mango cv. Ataulfo peel were obtained using a methanolic extraction, and their cellular antioxidant activity (CAA) and permeability were compared to those obtained for bound phenolics released by alkaline or acid hydrolysis. Gallic acid was found as a simple phenolic acid after alkaline hydrolysis along with mangiferin isomers and quercetin as aglycone and glycosides. Only gallic acid, ethyl gallate, mangiferin, and quercetin were identified in the acid fraction. The acid and alkaline fractions showed the highest CAA (60.5% and 51.5%) when tested at 125 µg/mL. The value of the apparent permeability coefficient (Papp) across the Caco-2/HT-29 monolayer of gallic acid from the alkaline fraction was higher (2.61 × 10−6 cm/s) than in the other fractions and similar to that obtained when tested pure (2.48 × 10−6 cm/s). In conclusion, mango peels contain bound phenolic compounds that, after their release, have permeability similar to pure compounds and exert an important CAA. This finding can be applied in the development of nutraceuticals using this important by-product from the mango processing industry.
Plant and Mammal Aquaporins: Same but Different
Authors: Laloux Timothée , Junqueira Bruna , Maistriaux Laurie , Ahmed Jahed , Jurkiewicz Agnieszka , Chaumont François
Published: February 2018

Aquaporins (AQPs) constitute an ancient and diverse protein family present in all living organisms, indicating a common ancient ancestor. However, during evolution, these organisms appear and evolve differently, leading to different cell organizations and physiological processes. Amongst the eukaryotes, an important distinction between plants and animals is evident, the most conspicuous difference being that plants are sessile organisms facing ever-changing environmental conditions. In addition, plants are mostly autotrophic, being able to synthesize carbohydrates molecules from the carbon dioxide in the air during the process of photosynthesis, using sunlight as an energy source. It is therefore interesting to analyze how, in these different contexts specific to both kingdoms of life, AQP function and regulation evolved. This review aims at highlighting similarities and differences between plant and mammal AQPs. Emphasis is given to the comparison of isoform numbers, their substrate selectivity, the regulation of the subcellular localization, and the channel activity.
Aspergillus fumigatus Detection and Risk Factors in Patients with COPD–Bronchiectasis Overlap
Authors: Everaerts Stephanie , Lagrou Katrien , Vermeersch Kristina , Dupont Lieven , Vanaudenaerde Bart , Janssens Wim
Published: February 2018

The role of Aspergillus fumigatus in the airways of chronic obstructive pulmonary disease (COPD) patients with bronchiectasis is currently unclear. We searched for a sensitive and noninvasive method for A. fumigatus detection in the sputum of COPD patients and addressed potential risk factors for its presence. Induced sputum samples of 18 COPD patients and 17 COPD patients with bronchiectasis were analyzed for the presence of A. fumigatus by culture, galactomannan detection, and PCR. Of the patients with COPD–bronchiectasis overlap, 23.5% had a positive culture for A. fumigatus versus 10.5% of COPD patients without bronchiectasis (p = 0.39). The median sputum galactomannan optical density index was significantly higher in patients with COPD and bronchiectasis compared with patients with COPD alone (p = 0.026) and ranged between the levels of healthy controls and A. fumigatus-colonized cystic fibrosis patients. Both the presence of bronchiectasis and the administration of systemic corticosteroids were associated with sputum galactomannan (p = 0.0028 and p = 0.0044, respectively) and showed significant interaction (p interaction = 0.022). PCR for Aspergillus was found to be a less sensitive method, but was critically dependent on the extraction technique. The higher sputum galactomannan levels suggest a more abundant presence of A. fumigatus in the airways of patients with COPD–bronchiectasis overlap compared with patients with COPD without bronchiectasis, particularly when systemic corticosteroids are administered.
Correction: Wen-I Liao, et al. Ac2-26, an Annexin A1 Peptide, Attenuates Ischemia-Reperfusion-Induced Acute Lung Injury. Int. J. Mol. Sci. 2017, 18, 1771
Authors: Liao Wen-I , Wu Shu-Yu , Wu Geng-Chin , Pao Hsin-Ping , Tang Shih-En , Huang Kun-Lun , Chu Shi-Jye
Published: February 2018

The authors would like to make a correction to their published paper [1][...]
Nano-Pore Size of Alumina Affects Osteoblastic Response
Authors: Mussano Federico , Genova Tullio , Serra Francesca , Carossa Massimo , Munaron Luca , Carossa Stefano
Published: February 2018

The rapid development and application of nanotechnology to biological interfaces has impacted the bone implant field, allowing researchers to finely modulate the interface between biomaterials and recipient tissues. In the present study, oxidative anodization was exploited to generate two alumina surfaces with different pore diameters. The former displayed surface pores in the mean range of 16–30 nm, while in the latter pores varied from to 65 to 89 nm. The samples were characterized by Field Emission Scanning Electron Microscopy (FESEM) and Energy Dispersive X-ray spectroscopy (EDX) analysis prior to being tested with pre-osteoblastic MC3T3-E1 cells. In vitro cell response was studied in terms of early cell adhesion, viability, and morphology, including focal adhesion quantification. Both the alumina samples promoted higher cell adhesion and viability than the control condition represented by the standard culture dish plastic. Osteogenic differentiation was assessed through alkaline phosphatase activity and extracellular calcium deposition, and it was found that of the two nano-surfaces, one was more efficient than the other. By comparing for the first time two nano-porous alumina surfaces with different pore diameters, our data supported the role of nano-topography in inducing cell response. Modulating a simple aspect of surface texture may become an attractive route for guiding bone healing and regeneration around implantable metals.
Effect of Ball Mill Treatment on the Physicochemical Properties and Digestibility of Protein Extracts Generated from Scallops (Chlamys farreri)
Authors: Wu Di , Wu Chao , Chen Hui , Wang Zhenyu , Yu Cuiping , Du Ming
Published: February 2018

The effects of ball mill treatment (0, 2, 4, 6, 8, and 10 min) on the physicochemical and digestible properties of scallops (Chlamys farreri) protein (CFP) were investigated. The CFP particle size decreased with increasing ball-milling time. The content of free sulfhydryl (SH) of CFP increased from 13.08 ± 0.25 μmol/g protein to 18.85 ± 0.24 μmol/g protein when the ball-milling time increased from 0 min to 10 min. A sharp increase of the surface hydrophobicity index (H0) from 48.53 ± 0.27 to 239.59 ± 0.37 was found when the ball-milling time increased from 0 min to 4 min. Furthermore, the foaming capacity increased from 46.08 ± 6.12% to 65.11 ± 1.05% with increasing ball-milling time from 0 min to 6 min, after which it reached a plateau. SDS-PAGE results showed that ball mill treatment did not change the primary structure of CFP. Digestible properties of BMCFP simulated gastrointestinal digestion as a function of ball mill treatment were analyzed by Tricine-SDS-PAGE and nitrogen recovery index. After 60 min of simulated human gastro digestion, nitrogen recovery index of CFP had a significant rise from 42.01 ± 0.31% to 58.78 ± 3.37% as the ball-milling time increased from 0 min to 6 min. Peptides from hydrolysates of Chlamys farreri protein (CFP) were identified by ultraperformance liquidchromatographysystem coupled to a Synapt Mass Quadrupole Time-of-Flight Mass Spectrometer (UPLC-Q-TOF-MS). After 2 h and 4 h of simulated human duodenal digestion, the number of peptides with 7–10 amino acids length increased apparently with the ball-milling time increased. This study presents an approach to investigating the effect of the ball-milling process on the physicochemical and digestible properties of CFP, which may provide valuable information on the application of CFP as an ingredient in food products.
Logarithmic Similarity Measure between Interval-Valued Fuzzy Sets and Its Fault Diagnosis Method
Authors: Lu Zhikang , Ye Jun
Published: February 2018

Fault diagnosis is an important task for the normal operation and maintenance of equipment. In many real situations, the diagnosis data cannot provide deterministic values and are usually imprecise or uncertain. Thus, interval-valued fuzzy sets (IVFSs) are very suitable for expressing imprecise or uncertain fault information in real problems. However, existing literature scarcely deals with fault diagnosis problems, such as gasoline engines and steam turbines with IVFSs. However, the similarity measure is one of the important tools in fault diagnoses. Therefore, this paper proposes a new similarity measure of IVFSs based on logarithmic function and its fault diagnosis method for the first time. By the logarithmic similarity measure between the fault knowledge and some diagnosis-testing samples with interval-valued fuzzy information and its relation indices, we can determine the fault type and ranking order of faults corresponding to the relation indices. Then, the misfire fault diagnosis of the gasoline engine and the vibrational fault diagnosis of a turbine are presented to demonstrate the simplicity and effectiveness of the proposed diagnosis method. The fault diagnosis results of gasoline engine and steam turbine show that the proposed diagnosis method not only gives the main fault types of the gasoline engine and steam turbine but also provides useful information for multi-fault analyses and predicting future fault trends. Hence, the logarithmic similarity measure and its fault diagnosis method are main contributions in this study and they provide a useful new way for the fault diagnosis with interval-valued fuzzy information.
NS-Cross Entropy-Based MAGDM under Single-Valued Neutrosophic Set Environment
Authors: Pramanik Surapati , Dalapati Shyamal , Alam Shariful , Smarandache Florentin , Roy Tapan Kumar
Published: February 2018

A single-valued neutrosophic set has king power to express uncertainty characterized by indeterminacy, inconsistency and incompleteness. Most of the existing single-valued neutrosophic cross entropy bears an asymmetrical behavior and produces an undefined phenomenon in some situations. In order to deal with these disadvantages, we propose a new cross entropy measure under a single-valued neutrosophic set (SVNS) environment, namely NS-cross entropy, and prove its basic properties. Also we define weighted NS-cross entropy measure and investigate its basic properties. We develop a novel multi-attribute group decision-making (MAGDM) strategy that is free from the drawback of asymmetrical behavior and undefined phenomena. It is capable of dealing with an unknown weight of attributes and an unknown weight of decision-makers. Finally, a numerical example of multi-attribute group decision-making problem of investment potential is solved to show the feasibility, validity and efficiency of the proposed decision-making strategy.