bluuebunny/crossref_metadata_2025 huggingface dataset:
Valorization of Vitellaria paradoxa butter in cosmetics and agrifood in Africa
Authors: Koudoro Yaya Alain  , Konfo Tétédé Rodrigue Christian  , Bakrou Orou Doro Emmanuel  , Félicien Avlessi  , Edwige Dahouenon-Ahoussi  , Dominique Sohounhloue
Published: January 2022

Forest species are very abundant in African ecosystems and contribute to the economy of households, through their use in cosmetics, pharmaceuticals and agri-food. Among these species, Vitellaria paradoxa (sapotaceae) is a tree that can reach about fifteen meters, which grows exclusively in wooded savannas in Africa. Its area of ​​distribution is Senegal, Mali, Burkina Faso, Guinea Bissau, Guinea, Sierra Leone, Côte d'Ivoire, Ghana, Togo, Benin, Nigeria, Cameroon, Chad and Ethiopia. The purpose of this study was to highlight the forms of valuation of shea butter in the food industry and in cosmetics. To do this, we carried out a literature review. The results revealed that shea butter is a fat extracted from the kernels of the shea fruit. It is obtained by shelling, drying and crushing the nuts. Crushed seeds and then mixed with water. Once immersed in water, the impurities will come out naturally from the butter and thus settle in the bottom of the container. Then, the butter that has remained on the surface is collected, and kneaded, to be cooked for a long time at a very low temperature. The water evaporates, leaving only room for the oil, which will be manually filtered through muslin and then conditioned. Once at room temperature, the butter (melted into oil) regains its solid and melting texture. This butter, for its properties, is on considerable importance in food industry and cosmetics. Thus, shea butter is used in cooking (edible oils), in pastry products, confectionery and in chocolate industry as a substitute for cocoa butter. In cosmetics, it is best known for its moisturizing and softening properties of the skin. It is also used as an excipient in cosmetic formulations such as ointments, shampoos, toilet soaps and in creams.
Evaluation of protective potentials of Vernonia amygdalina (Bitter leaf) extracts on some selected organs of cadmium chloride-induced hypertensive albino rats
Authors: Henrrietta Ogadimma Nnadi  , Vincent Ugochukwu Igbokwe
Published: January 2022

Many food components such as plant metabolites, have been shown to possess antioxidant activities. Vernonia amygdalina is widely consumed as vegetable for its rich array of phytochemicals and nutritional components which are attributed to its various health and medicinal benefits. The study evaluated the protective potentials of Vernonia amygdalina extracts on selected heart, Liver and Kidney of Cadmium Chloride-induced Hypertensive albino rats. The animals were induced hypertension with cadmium chloride. Total size of 50 albino rats of male and females were grouped according to sex in five different groups of ten rats per group; Control Group (1), Hypertensive Group (2), Standard group (3), methanol group (4) and n-hexane group (5). At the end of the study, blood was collected by cardiac puncture while the organs were harvested for histology test. Liver function evaluated was Aspartate Transaminase (AST), Alanine Aminotransferase (ALT) and Alanine Phosphatase (ALP). Renal function test was done following standard methods for estimation of serum Urea and Creatinine, Electrolyte and Calcium while heart, liver and kidney were subjected to histological technique. One way ANOVA was used for analysis of the collected data and was expressed as Mean ± SEM. Result of Hypertensive group showed significant increase in sodium level (p<0.05) when compared with Control group. Significant decrease was observed in Sodium values of Standard drug, Vernonia amygdalina methanol and n-hexane groups when compared with the hypertensive none treated Control. Significant decrease was observed in AST values of Test groups 4 and 5 while Total bilirubin value showed significant decrease in Group 4, when hypertensive control is compared with all other Groups. Total bilirubin values of Groups 4 and 5 showed significant decrease as compared Standard to all groups. The treatment with bitter leaf resulted in a reversal of values found in untreated hypertensive group compared with the test group. Heart, liver and kidney tissues showed no lesion or inflammation in all the groups except hypertensive none treated group that showed distorted patchy necrotic area in the histology test. The results of this study suggest that Vernonia amygdalina possesses protective potential against Cadmium chloride induced hypertension in albino rats.
Sifat Kimia dan Fisik Engay Food Berbasis Ikan Kembung dengan Penambahan Kedelai Hitam
Authors: Cahyati Anissa I , Nurrahman Nurrahman , Aminah Siti
Published: January 2022

Engay food is a type of food with a distinctively soft texture that is easy to swallow. This product is classified as a texture-modified food group. The primary ingredient used is mackerel fish, with the added nutritional benefit provided by black soybeans. The purpose of this research was to determine the effect of adding various concentrations of black soybeans on the physical and chemical characteristics of material-based engay food. A completely randomized experimental design was used in this study, which included 200 g of mackerel meat formulation and varying amounts of black soybean flour (0, 5, 10, 15, and 20%). Antioxidant activity, texture, and color were all determined during this study. The results indicated that increasing the concentration of black soybeans had a substantial effect on the chemical and physical properties of engay food made with mackerel. The greater the amount of black soybean added to the formulation, the higher the antioxidant activity, the lower the cohesiveness and gumminess, and the lower brightness of the yellow-red hue.

Keywords: Black soybean; chemical; engay food; mackerel fish; physical

 

ABSTRAK

Engay food adalah salah satu produk pangan dengan karakeristik tekstur yang lunak sehingga mudah ditelan. Produk ini termasuk dalam dalam kelompok makanan modifikasi tekstur. Bahan utama yang digunakan adalah ikan kembung dengan penambahan kedelai hitam yang diketahui berpotensi untuk meningkatkan nilai gizi. Tujuan penelitian ini untuk mengetahui pengaruh penambahan kedelai hitam terhadap karakteristik kimia dan fisik  dari engay food berbasis ikan kembung. Rancangan yang digunakan adalah rancangan acak lengkap dengan formulasi ikan kembung 200 g dan penambahan tepung kedelai hitam sebanyak 0, 5, 10, 15, dan 20%. Analisis yang dilakukan yaitu aktivitas antioksidan, tekstur dan warna. Hasil penelitian menunjukkan bahwa ada pengaruh penambahan konsentrasi kedelai hitam terhadap karakteristik kimia dan fisik dari engay food berbasis ikan kembung. penambahan kedelai hitam yang semakin banyak dalam engay food akan meningkatkan nilai aktivitas antioksidan, menurunkan nilai cohessiveness, adhesion, dan gumminess, akan tetapi menurunkan kecerahan dengan jenis warna yellow-red.

Kata Kunci: Engay food; fisik; ikan kembung; kedelai hitam; kimia
ANALISIS MOTIVASI BELAJAR INTRINSIK PADA PEMBELAJARAN MATEMATIKA KELAS XI SMA NEGERI 1 KEDUNGREJA
Authors: Indrayadi Alviansyah Putra , Rachmanto Dwi , Lukito Nandita Ratih Dewi , Rokhisa Zulfa Nur , Putranto Sumbaji
Published: January 2022

Penelitian ini bertujuan untuk menganalis motivasi belajar intrinsik pada pembelajaran matematika siswa SMA Negeri 1 Kedungreja. Subjek pada penelitian ini adalah seorang guru matematika dan 20 siswa kelas XI-MIPA 4 SMA Negeri 1 Kedungreja. Deskriptif kualitatif adalah metode yang digunakan pada penelitian ini. Pengumpulan data dilakukan dengan kuesioner dan wawancara. Hasil penelitian menunjukkan bahwa terdapat 15 orang siswa dengan kategori motivasi belajar intrinsik tinggi dan 5 orang siswa berkategori sedang. Analisis rata-rata skor per indikator untuk kedua kategori motivasi belajar intrinsik menunjukkan bahwa semua indikator berada pada kategori tinggi baik motivasi tinggi maupun sedang. Namun selisih rata-rata skor yang paling tinggi di antara ketiga indikator lain adalah pada indikator kebiasaan baik dengan nilai selisih 0.81. Penghitungan tersebut juga terkonfirmasi melalui wawancara bahwa siswa bermotivasi belajar intrinsik tinggi akan mempelajari materi sebelumnya jika besok adalah jadwal pelajaran matematika, sedangkan siswa dengan kategori motivasi belajar intrinsik sedang menyatakan bahwa jika besok adalah jadwal pelajaran matematika mereka hanya melihat materi sebelumnya.
ANALISIS KEMAMPUAN REPRESENTASI MATEMATIS PESERTA DIDIK PADA MATERI PROGRAM LINEAR
Authors: Mataheru Eunike Ester , Ratumanan Tanwey Gerson , Ayal Carolina Selfisina
Published: January 2022

Kemampuan representasi matematis adalah kemampuan menyajikan kembali notasi, simbol, tabel, gambar, grafik, diagram, persamaan atau ekspresi matematis lainnya ke dalam bentuk lain yang dimiliki oleh peserta didik dalam upaya mencari solusi dari suatu masalah yang dihadapi. Oleh karena itu, hendaknya guru memberikan kesempatan yang cukup bagi peserta didik untuk dapat melatih dan mengembangkan kemampuan representasi matematis sebagai bagian yang penting dalam menyelesaikan masalah yang diberikan. Pada kenyataannya kemampuan representasi matematis pada peserta didik masih saja rendah. Peserta didik masih sukar dalam menyelesaikan masalah matematik yang berkaitan pada aspek indikator verbal, indikator gambar, dan indiator simbol, hal ini bisa ditemukan pada materi program linear. Selain itu, materi program linear pun seringkali dianggap sebagai materi yang sulit oleh peserta didik dalam pembelajaran matematika. Penelitian ini bertujuan untuk mendeskripsikan kemampuan representasi matematis peserta didik meliputi representasi simbol, representasi gambar, representasi verbal pada materi program linear di kelas XI SMA Negeri 3 Ambon. Jenis Penelitian yang digunakan adalah penelitian kombinasi (mixed methods). Penelitian dilakukan di SMA Negeri 3 Ambon dengan jumlah subjek penelitian 36 orang dari kelas XI MIPA 4 dan subjek yang dipilih untuk diwawancarai yaitu berdasarkan hasil tes kemampuan representasi matematis. Dari hasil tes kemampuan representasi matematis pada materi program linear, peserta didik dikelompokan berdasarkan kategori sangat tinggi, tinggi, sedang, rendah, dan sangat rendah. Diambil subjek yang diwawancarai yaitu 1 peserta didik dengan kategori sangat tinggi, 1 peserta didik dengan kategori rendah, dan 1 peserta didik dengan kategori sangat rendah. Materi program linear diberikan untuk melihat kemampuan representasi matematis peserta didik. Persentase terbesar hasil tes peserta didik berada pada kategori sangat rendah. Berdasarkan hasil tes menunjukkan bahwa kemampuan representasi matematis peserta didik pada representasi simbol lebih tinggi dari representasi gambar dan representasi verbal. Sedangkan dari ketiga subjek yang diwawancarai ditemukan bahwa subjek cenderung memenuhi indikator kemampuan representasi simbol dibandingkan indikator kemampuan representasi gambar dan representasi verbal
PENERAPAN MODEL PEMBELAJARAN PROJECT BASED LEARNING BERBANTUAN GEOGEBRA UNTUK MENINGKATKAN HASIL BELAJAR SISWA
Authors: Nurhayati Nurhayati , Zuhra Fatma , Salehha Osey Putri
Published: January 2022

Penelitian ini didasari oleh guru yang jarang menggunakan model pembelajaran dan media untuk menunjang proses pembelajaran, sehingga siswa tidak tertarik untuk belajar. Tujuan dari penelitian ini adalah untuk mengetahui peningkatan hasil belajar siswa melalui model pembelajaran PjBL berbantuan GeoGebra pada materi SPLDV di kelas X di SMAN 2 Bireuen pada. Penelitian quasi eksperimen ini menggunakan pendekatan kuantitatif. Rancangan yang digunakan adalah Pretest Posttest Control Group Design. Seluruh siswa kelas X SMAN 2 Bireuen dijadikan populasi dalam penelitian ini. Pengambilan sampel menggunakan teknik purposive sampling. Instrumen pada penelitian ini berupa tes yang terdiri dari pretes dan postes. Untuk mengetahui peningkatan nilai pretes dan postes siswa menggunakan N-gain. Hasil perhitungan N-gain diperoleh bahwa penerapan model pembelajaran PjBL berbantuan GeoGebra mampu meningkatkan hasil belajar siswa
ANALISIS KEMAMPUAN BERPIKIR TINGKAT TINGGI SISWA PADA MATERI RELASI DAN FUNGSI KELAS VIII DI SMPN 1 TANJUNGANOM
Authors: Anggraini Ninda Sundari , Hamidah Dewi , Rahayu Dwi Shinta
Published: January 2022

Penelitian ini bertujuan untuk mengetahui kemampuan berpikir tingkat tinggi siswa pada materi relasi dan fungsi. Jenis penelitian ini adalah penelitian kualitatif dengan subjek penelitian adalah siswa kelas VIII-1 SMPN 1 Tanjunganom Tahun Pelajaran 2020/2021 dengan jumlah siswa 32 orang. Data yang diperoleh dari tes kemampuan berpikir tingkat tinggi (HOTS) dan wawancara. Analisis data yang digunakan berupa analisis taksonomi Bloom. Dari hasil penelitian yang dilakukan oleh peneliti menunjukkan bahwa persentase taksonomi bloom berdasarkan masing-masing level C4 (menganalisis), C5 (mengevaluasi), dan C6 (mencipta) adalah 61,98%, 47,17%, dan 48,96%. Dari hasil penelitian diperoleh kemampuan HOTS pada siswa yaitu 1 siswa dengan kategori sangat baik, 6 siswa dalam kategori baik, 22 siswa dalam kategori cukup, 3 siswa dalam kategori kurang, dan tidak ada siswa dalam kategori sangat kurang.
MISKONSEPSI MAHASISWA PADA MATERI HIMPUNAN: ANALISIS MENGGUNAKAN KRITERIA CERTAINTY OF RESPONSE INDEX
Authors: Disnawati Hermina , Deda Yohanis Ndapa
Published: January 2022

Penelitian ini bertujuan untuk mengetahui miskonsepsi mahasiswa tentang konsep himpunan menggunakan indikator certainty of response index (CRI). Subjek penelitian terdiri dari 89 orang mahasiswa semester 1 yang memprogram mata kuliah Pengantar Dasar Matematika (PDM). Metode penelitian yamg digunakan merupakan deskriptif kualitatif. Tes tertulis terdiri dari 4 soal pilihan ganda beralasan dan uraian digunakan untuk mengumpulkan data penelitian. Hasil penelitian menunjukkan bahwa berdasarkan  kriteria CRI, untuk soal nomor 1 tentang perbedaan himpunan dan bukan himpunan, terdapat 39% mahasiswa mengalami miskonsepsi, 33% mahasiswa tidak tahu konsep dan 28% mahasiswa yang mengetahui konsep dengan benar. Pada soal nomor 2 tentang tiga cara menyajikan himpunan bilangan asli, cacah, prima dan bulat, ditemukan terdapat 12% mahasiswa mengalami miskonsepsi dan sebanyak 76% mahasiswa tidak tahu konsep karena menebak dan kurangnya pengetahuan, sisanya  11 % mahasiswa memahami konsep dengan baik.  Untuk soal nomor 3, tentang operasi himpunan ditemukan terdapat 30%  mahasiswa mengalami miskonsepsi, 45% tidak tahu konsep dan sisanya 24% memamahi konsep dengan tepat. Selanjutnya untuk soal nomor 4, soal cerita operasi himpunan diperoleh hasil bahwa dari 19% mahasiswa yang mengikuti tes mengalami miskonsepsi, 57% mahasiswa tidak paham konsep dan hanya 24% mahasiswa yang memahami konsep dengan benar. Dengan kata lain, dari 4 soal yang diujikan kepada mahasiswa, soal nomor 1 dan 3 paling banyak ditemukan mahasiswa mengalami miskonsepsi. Meskipun soal nomor 2, ditemukan paling sedikit mahasiswa mengalami miskonspesi namun pada soal ini hampir 80% mahasiswa tidak tahu konsep dengan benar
ANALISIS MATERNAL FUNCTIONING PADA IBU DENGAN BAYI BARU LAHIR YANG DIRAWAT DI HIGH CARE UNIT RSIA ANANDA KOTA MAKASSAR
Authors: Nurbina Siti , Jalaluddin Syatirah , Nurdin Azizah
Published: January 2022

Perawatan bayi di ruang rawat memicu pemisahan paksa antara ibu dan bayi yang menyebabkan terganggunya perawatan bayi oleh ibunya serta interaksi ibu dan bayi yang tidak optimal. Kurangnya intensitas pertemuan ibu dengan bayi sangat berdampak pada pertumbuhan dan perkembangan kognitif dari bayi tersebut. Penelitian bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan maternal functioning pada ibu dengan bayi yang membutuhkan perawatan intensif. Metode yang digunakan dalam penelitian ini adalah deskriptif dengan rancangan cross sectional. Penelitian dilakukan bulan Januari 2020 di Rumah Sakit Ibu dan Anak (RSIA) Ananda Kota Makassar Populasi pada penelitian ini adalah seluruh ibu postpartum yang bayinya dirawat di high care unit RSIA Ananda Kota Makassar. Pengambilan sampel dilakukan dengan menggunakan teknik non-probability sampling yaitu purposive sampling dengan jumlah sampel sebanyak 50 yang memenuhi kriteria. Hasil penelitian mendapatkan lama pendidikan formal, tipe persalinan, paritas ibu serta diagnosis yang menyebabkan bayi yang dirawat di high care unit tidak memiliki hubungan yang signifikan dengan maternal functioning.

Kata Kunci: maternal functioning, high care unit, Barkin index of maternal functioning
SOSIOKULTURAL MEMPENGARUHI KETIDAKPATUHAN TERAPI ANTIRETROVITAL PADA ODHIV DI MALUKU: QUALITATIVE STUDY
Authors: Siahaya Presli Glovrig , Thobari Jarir At , Astuti Indwiani , Sanjoto Hari Agus
Published: January 2022

HIV merupakan permasalah global dengan angka kematian yang tinggi. Pengobatan paling efektif pada ODHIV hanyalah dengan terapi ARV. Tujuan utama dari terapi arv adalah untuk meningkatan kelangsungan hidup bebas penyakit dengan menekan replikasi HIV dan meningkatkan fungsi kekebalan. Ketidakpatuhan terhadap terapi ARV akan membeir dampak pada kegaggalan pengobatan. Kegagalan pengobatan pada ODHIV, menyebabkan penurunan CD4 dan infeksi opurtunitik. Tujuan penelitian ini untuk mengetahui bagaiman factor sosikultural dapat mempengaruhi ketidakpatuhan terapi ARV pada ODHIV di Maluku. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan studi kasus. Jumlah informan dalam penelitian ini sebanyak 12 informan, dengan menggunakan in-depth interview untuk memperoleh data. Analisis transkrip wawancara melalui koding, menentukan kategori, sub-tema dan tema. Hasil penelitian yang didapatkan stigma, diskriminasi dan tertutup dengan status HIV merupakan faktorsosial yang mempengaruhi ketidakpatuhan terapi ARV. Faktor prespsi ODHIV, bila HIV merupakan santet, sehingga ODHIV menggunakan cara lain untuk pengobatan. Faktor religious dapat mempengaruhi ketidakpatuhan terapi ARV. Faktor culture dapat mempengaruhi ketidakpatuhan terapi RV. Faktor pengobatan alternative dapat mempengaruhi ketidakpatuhan terapi ARV pada ODHIV. Kesimpulan dari penelitian ini factor sosiokultural yang mempengaruhi ketidakpatuhan teapi ARV yaitu factor social, factor presepsi, factor religious, factor culture dan faktor pengobtan alternative.
ACADEMIC BUOYANCY MAHASISWA FAKULTAS KEDOKTERAN DITINJAU BERDASARKAN JALUR MASUK PERGURUAN TINGGI DI UNIVERSITAS PATTIMURA AMBON
Authors: Hutagalung Johan Bension , Saija Alessandra Flowrence , Noija Stazia
Published: January 2022

Pendahuluan. Academic buoyancy merupakan kemampuan seseorang untuk dapat berhasil menghadapi permasalahan akademis dan tantangan sehari-hari, seperti nilai yang buruk, mengejar deadline, tekanan ketika menghadapi ujian dan tugas-tugas yang sulit. Tujuan.  Penelitian ini bertujuan untuk mengetahui gambaran mengenai academic buoyancy pada mahasiswa serta perbedaan tingkat Academic Buoyancy pada mahasiswa di Fakultas Kedokteran Universitas Pattimura. Metode. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan deskriptif. Desain penelitian cross sectional, dengan menggunakan instrument penelitian berupa kuesioner dan sampel penelitian sebanyak 394 mahasiwa tahun ajaran 2019/2020. Hasil. Hasil penelitian menunjukkan tingkat Academic Bouyancy pada mahasiswa Fakultas Kedokteran Universitas Pattimura cukup baik dengan persentase sebanyak 61% dari total sampel, dan tidak ditemukan perbedaan yang bermakna antara tingkat Academic Bouyancy berdasarkan jalur masuk (p>0.05). Dengan demikian, hasil penelitian ini secara tidak langsung mengindikasikan bahwa mahasiswa Fakultas Kedokteran Universitas Pattimura memiliki kemampuan yang cukup baik dalam menghadapi hambatan-hambatan akademis yang dialami dalam proses pendidikan kedokteran.

 Kata Kunci : Academic buoyancy, perguruan tinggi, gambaran
KARAKTERISTIK PASIEN PENDERITA NEUROPATI PERIFER DIABETIK DI POLIKLINIK SARAF RSUD Dr. M. HAULUSSY AMBON TAHUN 2016-2019
Authors: Tofure Ian Risaldy , Huwae Laura B S , Astuty Eka
Published: January 2022

Penderita Diabetes Mellitus dalam jangka waktu yang lama bisa mengalami neuropati perifer diabetik. Penelitian ini bertujuan untuk mengetahui karakteristik pasien penderita neuropati perifer diabetik di Poliklinik saraf RSUD Dr. M. Haulussy Ambon tahun 2016-2019. Penelitian ini merupakan deskriptif observasional dengan pendekatan cross sectional 28 orang (sampel) yang didapat dengan teknik total sampling. Sampel dalam penelitian ini adalah penderita penderita neuropati perifer diabetik di Poliklinik Saraf RSUD Dr. M. Haulussy Ambon tahun 2016-2019. Hasil penelitian menunjukkan bahwa usia pasien neuropati perifer diabetik yang banyak adalah >55 tahun sebanyak 20 pasien (71,43%), jenis kelamin perempuan sebanyak 17 pasien (60,71%), lama menderita DM adalah >5 tahun sebanyak 21 pasien (75%), hasil pengecekan gula darah sewaktu pasien yang paling banyak adalah kadar gula darah 90-199 mg/dL sebanyak 25 pasien (89,29%), semua pasien memiliki riwayat penyakit penyerta dan terapi farmakologi yang banyak diterima oleh pasien adalah Obat Hipoglikemik Oral (OHO) sebanyak 25 pasien (89,29%). Semakin bertambahnya usia maka resiko terjadinya komplikasi neuropati semakin meningkat. Namun, hal ini tidak menutup kemungkinan kejadian neuropati perifer dapat dirasakan penderita diabetes yang masih muda.

 Kata Kunci: Neuropati Perifer diabetik, gula darah, Diabetes Melitus
ISPARTA’DA KIRSAL TURİZMİN GELİŞİMİ : KUYUCAK KÖYÜ ÖRNEĞİ
Authors: KILINÇ İsmail
Published: January 2022

Dünya genelinde olduğu gibi Türkiye’de de turizm sektörü hızla gelişmeye devam etmekte; ülkede turizmi geliştirmeye yönelik politikalar uygulanmaktadır. Kalkınma planları turizm sektörünün geliştirilmesini ve turizm aktivitelerinin çeşitlendirilmesini öngörür. Bu doğrultuda Türkiye’de kırsal turizmin desteklenerek geliştirilmesi hedeflenmiştir. Turizm, kırsal kalkınmanın sağlanması ve bölgeler arası gelişmişlik farklarının asgariye indirilebilmesi için önemli bir araç ve istihdam kaynağıdır. Buradan hareketle çalışmada Kuyucak Köyü örneğinde Isparta’da kırsal turizm potansiyeli ve gelişimi SWOT analizi yöntemiyle incelenmiştir. Analiz sonuçlarına göre; turistik ürün olarak çekiciliği bulunan lavanta bahçelerinin bölgede mevcut ve yaygın olması, lavantanın bölgeye çekicilik katması, gezi ve fotoğraf çekimleri için lavanta bahçelerinin elverişli olması, köyde bulunan lavanta bahçelerinin yerel ve ulusal medyada yer almaya başlamış olması güçlü yönler olarak öne çıkmaktadır. Zayıf yönler arasında lavantanın çiçeklenmesine bağlı olarak turizm sezonunun çok kısa olması, turizme yönelik yapıların estetik kaygı ve doğallıktan uzak, derme-çatma olması, bölgede büyük grupları ağırlayabilecek kafe ve restoranların yetersiz olması sayılabilir.
Effectiveness of adaptive facade with helicone mechanisms on energy values and natural lighting in Indonesia
Authors: Anantama Aldhi Nugraha , Hariyadi Agus
Published: January 2022

The annual growth of energy consumption in both residential and public buildings has been established globally as been significantly increasing. Therefore, the proposed active and passive building designs are intended to provide convenience and greatly reduce the high energy requirements, before considering mechanical systems (associated with fossil fuel-based energy consumption). This encourages the development of a new design, such as the Climate Adaptive Building Shell (CABS). This study aims to assess the effectiveness of CABS with Helicone mechanisms on energy and natural lighting, as well as its influential factors. The parametric modeling simulation method was applied to compare the energy and natural lighting aspects, between the adaptive and static facades of the Helicone mechanism. The results indicated that the adaptive facade was more effective than the static, based on energy and natural lighting. It was also found that the 30° adaptive configuration with the Helicone mechanism was the most effective. These results were influenced by several factors, i.e., the small turning angle (30° and 150° (-30°) and the anticlockwise direction of the adaptive facade rotation.
Adaptive reuse approach towards visual character change in conservation buildings
Authors: Devitasari Amalia , Suprapti Atik , Harsritanto Bangun I. R.
Published: January 2022

Semarang Gallery resulted from a heritage building conservation project reused with a new function or known as adaptive reuse, which indicates that it can cause changes in its visual character. This study aims to find the level of change in the visual character of the exterior, interior, and at close range of Semarang Gallery due to the adaptive reuse approach. This research uses a qualitative method, with graphical and descriptive data analysis. The results of the analysis show that the adaptive reuse approach changes the existing building typology, which requires adapting to technical improvements in almost all aspects of the building; thus giving rise to changes in the visual character of the exterior, interior, and at close range with different levels of significance. Changes that are in line with conservation principles can increase its parameter function’s value, on the contrary; inconsistencies can remove the distinctiveness of the visual character.
The quality of biophilic elements in child-friendly open space
Authors: Nugroho Agung Murti
Published: January 2022

There are many city parks currently used as public spaces and children's play facilities in Indonesia that do not meet the criteria for child-friendly open spaces. It is, however, important to note that biophilic elements are the natural environment components determining the quality of city parks. Therefore, this research was conducted to evaluate the criteria, perceptions, and development of biophilic elements in a child-friendly open space using Merjosari park in Malang which is one of those developed to achieve a child-friendly city as the case study. The biophilic elements criteria were determined using the Analysis Hierarchy Process (AHP) method while the perception of elements used the Importance Performance Analysis (IPA) method. First, the results showed the main criterion for the biophilic element according to experts is well-being while the highest sub-criterion is a safe space. Second, the seating element was found to be the visitors’ perception of quality based on the highest level of suitability while the garden element has the highest service performance and safe space had the highest level of importance. Third, playing equipment was recommended to be prioritized in the development of biophilic elements quality based on its high value in the IPA analysis. Finally, safe space was discovered to be the most important biophilic element of child-friendly open space at Merjosari Park, Malang City according to expert criteria and visitors’ perception.
The persistence and spatial transformations of traditional Joglo house according to hamemayu hayuning bawana philosophy
Authors: Michelle Brigitta , Purbadi Yohanes Djarot
Published: January 2022

This research aimed to explain the conceptual persistence of spatial transformations in the Joglo house nDalem Puspodiningratan based on Hamemayu Hayuning Bawana philosophy. This philosophy is the public wisdom directed towards maintaining a harmonious relationship between humans and each other, nature, and God. This philosophy is applied in several dimensions of the Javanese life such as the architecture which is meaningfully designed. Moreover, the Hamemayu Hayuning Bawana is observed to be playing an important role in the spatial configuration of the traditional Joglo house. It is important to note that nDalem Puspodiningratan is a traditional Joglo house with a well-maintained condition and which undergoes a spatial transformation due to the inhabitation of alternating families. This research was, therefore, conducted using visual observation and documentation, literature review, interviews, graphic method, and comparison to explore the Joglo transformation data and background. The results showed the Joglo nDalem Puspodiningratan persisted in preserving the Hamemayu Hayuning Bawana's philosophical principles despite the spatial transformations. Meanwhile, the transformations discovered to be violating the traditional house rules are believed to be reducing the Hamemayu Hayuning Bawana practice while those observed to be following the rules maintain the practice. There is a need for further research on the transformations of traditional buildings in other cases of the traditional Javanese architecture to show the existence of spatial transformations and conceptual persistence related to Hamemayu Hayuning Bawana.
Space syntax analysis of urban housing transformation in Indonesia
Authors: Putra Gierlang Bhakti
Published: January 2022

Previous researches on urban housing transformation in Indonesia focused on the privacy and observable morphological changes of the house. This study aims to compare the spatial configuration between the original and transformed plan of the urban houses in Indonesia. Six houses in Jatiwaringin Asri, Bekasi were investigated as part of the case study. The original plan and transformed plan of the houses are obtained through the interviews with the occupants of the houses. The plans were analyzed graphically and mathematically using space syntax. The results show that the open plan space is central in both original and transformed plan. There is strong segregation between public and private area but the interior of the houses maintain low hierarchical organization.
CHARACTERISTICS OF GEOPHYSICAL FIELDS OF THE PAVLIKOVSKOE GOLD ORE DEPOSIT (YANO-KOLYMA METALLOGENIC BELT)
Authors:   N.A. Shilo North-East Interdisciplinary Scientific Research Institute, Khasanov I. M. , Tkachev A.V. ,   N.A. Shilo North-East Interdisciplinary Scientific Research Institute, Koshurnikov A.V. ,   Lomonosov Moscow State University, Ganov A.P. ,   N.A. Shilo North-East Interdisciplinary Scientific Research Institute
Published: January 2022

The presented work provides the results of the analysis of the geophysical fields of the gold deposit, as well as some of their characteristic features. A set of geophysical studies and data processing techniques for solving the problems of gold mineralization forecast within the Yano-Kolyma metallogenic belt are presented. Based on the interpretation of the complex of geophysical data, geological and geophysical indications of gold mineralization are proposed in the following hierarchic sequence: ore cluster – ore field – mineralized zone – ore body. One of the main interpretation techniques in determining prospecting indicators of potential ore bodies (or high-grade intervals) is to study induced polarization frequency responses.
The Defiantly Unfashionable Dr LeDonne
Authors: Werth Paul W.
Published: January 2022

John P. LeDonne’s Forging of a Unitary State represents the culmination of a long and illustrious career in the study of various aspects of Russia’s early-modern experience. This review offers a critical assessment of this important monograph, focusing above all on the author’s contrarian conception of Russia-as-empire and his defiant determination to shun the fashionable in favor of the fundamental. It pays particular attention to LeDonne’s claim that in the crucial period between the reigns of Aleksei Mikhailovich (1645–76) and Nicholas I (1825–55) Russia was aspiring to construct not an empire rooted in difference, but a unitary state featuring broadly homogeneous territorial organization, institutions, and practices. It also explores “superstratification,” LeDonne’s distinct conception of elite integration. It ends with questions that remain unanswered in LeDonne’s account.
The Return of longue durée in Political History of the Russian Empire
Authors: Semyonov Alexander
Published: January 2022

The present intervention makes a mental experiment of thinking about recent historiographic “turns” in terms of “returns.” It takes its point of departure from the recent book by John LeDonne Forging a Unitary State: Russia’s Management of the Eurasian Space, 1650–1850. This book shows how much is needed to be done in terms of returning to the institutional, military, and legal history of the Russian imperial state. But there is also a return to the long-term historical perspective that presents the challenge of constructing a coherent historical narrative when the process of imperial expansion produced the growing diversity of the imperial realm. This challenge can be solved and the narrative can be stabilized by projecting nation-centered categories on to the past experience (such as “majority” and “minority”). But the same long-term perspective can also empower historians to align their analytical language with the grammar of the imperial archive and lexicon of the political praxis and register shifts and ruptures in the grand trajectory spanning several centuries.
Author’s Response
Authors: LeDonne John P.
Published: January 2022

The author thanks the panelists for their comments. He appreciated their raising questions in need of further study and he tried to answer them: the concept of core power, security fringe, limits of Russian expansion, and he himself raised additional questions. One of the most intractable questions raised by Barbara Skinner concerned the role of the Jesuits in the conflict between the Orthodox and Catholic churches; another concerned the meaning of the phrase “the partitions of Poland.” The author answered them hopefully to her satisfaction. Semyonov placed the rise of the Russian Empire in the broad context of Eurasian geopolitics and the author responded by submitting a number of issues in need of further study. He only regrets that no one raised the broad issue of the roleof the law and its codification as a factor of integration, and expresses the hope that this panel will raise an awareness among interested scholars of strategic and economic issues.
Guns, Schools, and Democracy: Adolescents Imagining Social Futures Through Speculative Civic Literacies
Authors: Mirra Nicole , Garcia Antero
Published: January 2022

This article analyzes how guns emerged as both urgent topics of dialogue and common features of everyday life for 228 students and their teachers in six communities across the United States who participated in the Digital Democratic Dialogue (3D) Project, a year long social design-based experiment aimed at foregrounding youth voice and fostering connection across lines of geographic and ideological difference. We trace the myriad ways that guns literally and discursively shaped the multiple ecological contexts of the 3D Project in order to detail youth sociopolitical learning and extend traditional models of civic education. We propose a paradigm of speculative civic literacies that privileges a collaborative push toward democratic interrogation and innovation over integration into existing civic and political structures.
Impact of subjective dizziness on motor and non-motor symptoms in patients with early stages of Parkinson's disease
Authors: Kwon Kyum-Yil , Park Suyeon , Lee Eun Ji , Lee Mina , Ju Hyunjin
Published: January 2022

Clinicians sometimes encounter patients with Parkinson’s disease complaining of dizziness in real clinical settings. We sought to identify the relationship between self-perceived dizziness and motor or non-motor symptoms, especially in Parkinsonian patients in the early stages. Eight-six patients with less than five years of Parkinson’s disease duration were recruited. We used the dizziness handicap inventory to access self-reported dizziness in patients with early Parkinson’s disease. Parkinsonian motor symptoms such as postural instability and gait difficulty and non-motor features for global cognitive function, depressive mood, anxiety state, fatigue state, and autonomic dysfunction were measured using representative scales. Linear regression analysis demonstrated that the dizziness handicap inventory score was significantly related to postural instability and gait difficulty, anxiety, gastrointestinal, and cardiovascular domain of dysautonomia. In addition, the dizziness handicap inventory score was positively correlated with scores for postural instability and gait difficulty, anxiety, gastrointestinal, and cardiovascular dysautonomia. We found that self-reported dizziness was highly linked to postural instability and gait difficulty, anxiety, gastrointestinal and cardiovascular dysfunctions in patients with early Parkinson’s disease. Further follow-up studies on the association between dizziness and the pathophysiology of Parkinson’s disease are needed.
The effect of insulin receptor deletion in neuropeptide Y neurons on hippocampal dependent cognitive function in aging mice
Authors: Goodman Elisabeth K. , Mitchell Caitlin S. , Teo Jonathan D. , Gladding Joanne M. , Abbott Kirsten N. , Rafiei Neda , Zhang Lei , Herzog Herbert , Begg Denovan P.
Published: January 2022

Insulin is known to act in the central nervous system to regulate several physiological and behavioural outcomes, including energy balance, glucose homeostasis and cognitive functioning. However, the neuronal populations through which insulin enhances cognitive performance remain unidentified. Insulin receptors are found in neuropeptide-Y (NPY) expressing neurons, which are abundant in the hypothalamus and hippocampus; regions involved in feeding behaviour and spatial memory, respectively. Here we show that mice with a tissue specific knockout of insulin receptors in NPY expressing neurons (IRl⁢o⁢x/l⁢o⁢x; NPYC⁢r⁢e⁣/+) display an impaired performance in the probe trial of the Morris Water Maze compared with control mice at both the 6 and the 12, but not at the 24 months time point, consistent with a crucial role of insulin and NPY in cognitive functioning. By 24 months of age all groups demonstrated similar reductions in spatial memory performance. Together, these data suggest that the mechanisms through which insulin influences cognitive functioning are, at least in part, via insulin receptor signaling in NPY expressing neurons. These results also highlight that cognitive impairments observed in aging may be due to impaired insulin signaling.
Cognitive estimation of speed, movement and time across the lifespan
Authors: Tapia Jose L. , Rocabado Francisco , Duñabeitia Jon Andoni
Published: January 2022

We investigated the role of age and gender in cognitive estimation abilities. Participants completed two online tasks, where different categories of estimation were assessed (speed estimation by time and distance, and auditory estimation). Data from a total of 18886 participants (9911 females) with ages between 18 and 65 years old were gathered. Results showed variations in the estimation capacity as a function of age, with a slow but progressive decline. Estimates of duration and sound seemed to be more affected by age than estimates of speed and movement. Overall, male participants showed a better performance on both auditory and visual estimation tasks compared to females.
Dichotomous effects of autophagy on infarct volume in experimental permanent/transient ischemic stroke model: a systematic review and meta-analysis
Authors: Rezabakhsh Aysa , Vahed Nafiseh , Hosseinifard Hossein , Rahbarghazi Reza , Salehnia Fatemeh , Sadeghpour Yalda , Sanaie Sarvin
Published: January 2022

According to the recent findings, autophagy modulation is being a potential therapeutic target in the management of ischemic stroke in a pre-clinical setting. However, the pros and cons of autophagic response strongly depend on the activation time of autophagy after injury. In this systematic review, we aimed to explore the impacts of pharmacological modulation of autophagy on infarct size in experimental ischemic stroke models. Based on our preliminary search, 3551 publications were identified. Of twenty-nine publications that met the inclusion criteria, twenty studies reported infarct volume reduction by percentage (%) with no evidence of any publication bias while nine studies reported by mm3, which had publication bias (39.25 units, standardized mean differences (SMD) = 41.92, 95% confidence interval (CI): 30.33 to 53.51). Based on a meta-analysis, the point estimate (pooled mean difference) for improvement of infarct volume during autophagy modulation according to the mm3 and percentage were 35.64 (mean differences (MD) = 35.64, 95% CI: 26.43 to 44.85, z-value = 7.58, p-value < 0.001) and 14.38 (MD = 14.38, 95% CI = 10.50 to 18.26, z-value = 7.26, p < 0.001) units, respectively. Despite the undeniable role of autophagy in ischemic stroke, the dichotomous effects of autophagy regarding infarct volume reduction should be taken into account. Based on our findings, the studies included in this meta-analysis mostly reported a negative relation between autophagy induction and stroke volume development due to over-activity of autophagy upon the severe ischemic stroke; therefore, further pre-clinical studies are also recommended to establish adjusted autophagy with considering a time-dependent effect as a promising therapeutic target.
Neuropsychological correlates of cerebellar volumes in multiple sclerosis: an MRI volumetric analysis study
Authors: Iliadou Paraskevi , Bakirtzis Christos , Ioannidis Panagiotis , Possin Katherine , Zygouris Stelios , Sintila Styliani-Aggeliki , Grigoriadis Nikolaos , Aretouli Eleni
Published: January 2022

The hallmark of Multiple Sclerosis (MS) pathophysiology is the damage to the myelin sheath around axons. The cerebellum is a predilection site for demyelination with a well-recognized role in motor and a rather understudied contribution to cognitive functions. The aim of this study is to investigate patterns of cerebellar grey and white matter pathology, expressed as reduced volume, as well as cortical thickness and their potential contribution to cognitive performance and disability status of patients with MS. 24 patients with MS underwent extensive neuropsychological assessment using paper and pencil tests and the Brain Health Assessment (BHA) tablet-based battery. Cerebellar lobular volumes and thickness were calculated using a volumetric analysis with automated segmentation of the cerebellum and its lobules. The main findings are a reduction of cerebellar grey matter (CGMV) and white matter volumes (CWMV) in lobule X and a widespread cerebellar cortical thinning in patients. Overall disease severity and neurological disability, assessed with the Expanded Disability Status Severity Scale, was correlated with fatigue and information processing speed tasks, but not with CGMV and CWMV. CWMV and CGMV of lobule I–II was negatively correlated with information processing speed, as well as visuospatial memory tests and, finally, inverse cortical thinning associations were noted between the whole cerebellum, lobule I–II, lobule III, lobule VI, Crus I, lobule VIIIA and information processing speed and verbal fluency tasks. The inverse associations observed may represent a compensatory mechanism activated in MS engaging additional high-level cortical areas functionally interconnected with the damaged cerebellum, in order to cope with the cognitive demands of a task.
Research progress of natural products for the treatment of ischemic stroke
Authors: Li Jiaxin , Zhao Tingting , Qiao Hanzi , Li Yanling , Xia Mengyao , Wang Xiaoyu , Liu Chuanguo , Zheng Tingting , Chen Renjie , Xie Yicheng , Wu Jibiao , Wei Xia , Li Jun , Feng Yu , Sun Peng
Published: January 2022

Stroke is a leading cause of death and disability world-widely. The incidence rate of stroke has been increasing due to the aging population and lifestyle changes. At present, the only drug approved by the US Food and Drug Administration (FDA) for the treatment of ischemic stroke is tissue plasminogen activator (t-PA), but its clinical application is greatly limited because of its narrow time window and bleeding risk. Natural products have a long history of being used in traditional medicine with good safety, making them an important resource for the development of new drugs. Indeed, some natural products can target a variety of pathophysiological processes related to stroke, including oxidative stress, inflammation and neuronal apoptosis. Therefore, the development of high-efficiency, low-toxicity, safe and cheap active substances from natural products is of great significance for improving the treatment alternatives of patients with stroke. This article reviews the neuroprotective effects of 33 natural compounds by searching recent related literature. Among them, puerarin, pinocembrin, quercetin, epigallocatechin-3-gallate (EGCG), and resveratrol have great potential in the clinical treatment of ischemic stroke. This review will provide a powerful reference for screening natural compounds with potential clinical application value in ischemic stroke or synthesizing new neuroprotective agents with natural compounds as lead compounds.
Effect of vanillic acid on pentylenetetrazole-kindled rats: Nrf2/HO-1, IGF-1 signaling pathways cross talk
Authors: El-Hefnawy Mahmoud A. , Yehia Asmaa , Nashar Eman M. El , Saad Somaya , Obydah Walaa , Alghamdi Mansour A. , Alasmari Wardah A. , Hussein Abdelaziz M.
Published: January 2022

Vanillic acid (VA) exhibited antioxidant and neuroprotective properties in some neurodegenerative disorders. So, the current study examined the neuroprotective potential of VA as an antiepileptic agent in pentylenetetrazole (PTZ)-induced epileptic rats and the prospective role of Insulin like growth factor-1 (IGF-1) and nuclear factor-2 erythroid-related factor-2 (Nrf2)/heme oxygenase-1 (HO-1) pathway in this respect. Thirty male albino rats were equally subdivided into 3 groups; (1) normal control (NC) group, (2) PTZ-group: received PTZ (50 mg/Kg, i.p. every other day) for 14 days, and (3) PTZ + VA group: received PTZ and VA (50 mg/Kg daily for 2 weeks). The seizure score and latency were evaluated after PTZ injection. Also, the markers of oxidative stress (malondialdehyde (MDA), catalase, and reduced glutathione (GSH)), histopathological examination, the expression of glial fibrillary acidic protein (GFAP) (a marker of astrocytes) IGF-1, Nrf2, and HO-1 were assessed in the brain tissues by the end of the experiment. PTZ caused significant decrease in seizure latency and significant increase in seizure score by the end of the experiment (p < 0.01). This was associated with significant increase in MDA and GFAP with significant decrease in GSH, total antioxidant capacity (TAC) and IGF-1 in brain tissues compared to normal group (p < 0.01). On the other hand, treatment with VA caused significant attenuation in PTZ-induced seizures which was associated with significant improvement in oxidative stress markers and downregulation in GFAP and upregulation of Nrf2, HO-1 and IGF-1 in CA3 hippocampal region (p < 0.01). VA showed neuroprotective and anti-epileptic effects against PTZ-induced epilepsy which probably might be due to its antioxidant properties and upregulation of Nrf2/HO-1 pathway and IGF-1.