bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantum Error-Correcting Codes Based on Orthogonal Arrays
Authors: Yan Rong , Pang Shanqi , Chen Mengqian , Yang Fuyuan
Published: April 2023

In this paper, by using the Hamming distance, we establish a relation between quantum error-correcting codes ((N,K,d+1))s and orthogonal arrays with orthogonal partitions. Therefore, this is a generalization of the relation between quantum error-correcting codes ((N,1,d+1))s and irredundant orthogonal arrays. This relation is used for the construction of pure quantum error-correcting codes. As applications of this method, numerous infinite families of optimal quantum codes can be constructed explicitly such as ((3,s,2))s for all si≥3, ((4,s2,2))s for all si≥5, ((5,s,3))s for all si≥4, ((6,s2,3))s for all si≥5, ((7,s3,3))s for all si≥7, ((8,s2,4))s for all si≥9, ((9,s3,4))s for all si≥11, ((9,s,5))s for all si≥9, ((10,s2,5))s for all si≥11, ((11,s,6))s for all si≥11, and ((12,s2,6))s for all si≥13, where s=s1⋯sn and s1,…,sn are all prime powers. The advantages of our approach over existing methods lie in the facts that these results are not just existence results, but constructive results, the codes constructed are pure, and each basis state of these codes has far less terms. Moreover, the above method developed can be extended to construction of quantum error-correcting codes over mixed alphabets.
Weighted Gene Co-Expression Network Analysis Reveals Key Pathways and Hub Genes Associated with Successful Grafting in Pecan (Carya illinoinensis)
Authors: Mo Zhenghai , Jiang Xiaozhuang , Zhang Yan , Zhai Min , Hu Longjiao , Xuan Jiping
Published: April 2023

Patch budding (bud grafting) is a commonly used method for pecan reproduction; however, the grafting survival rate varies with cultivars. Clarifying the underlying mechanisms of successful grafting is pivotal for graft technique improvement. Here, weighted gene co-expression network analysis (WGCNA) was conducted to dissect the key pathways and genes related to the successful grafting of pecan. Based on the transcriptome data of two contrasting cultivars (an easy-to-survive cultivar ‘Pawnee’ and a difficult-to-survive cultivar ‘Jinhua’) in response to budding, all the genes with variable transcripts were grouped into 18 modules. There were two modules that were significantly correlated with the trait of different cultivars. Enrichment analysis showed that several enriched gene ontology (GO) terms were related to oxidative detoxification and genes associated with hormone signaling pathway occupied a high ratio for the two modules. A total of 52 hub genes were identified, and 48 showed promoter polymorphisms between the two cultivars. Our study suggested that oxidative detoxification and hormone signaling were probably the key pathways for the successful grafting of pecan. The 48 hub genes identified here might be the key genes that led to the divergence of graft survival rates among different pecan cultivars. Our results will lay a foundation for future graft technique improvement in pecan.
Furnishing a Recreational Forest—Findings from the Hallerwald Case Study
Authors: Cervinka Renate , Schwab Spletzer Markus , Haluza Daniela
Published: April 2023

While the beneficial effects of forests on health and well-being are broadly investigated, little is known on the restorative effects of forest infrastructure. Thus, this study assessed the perceptions of installing furniture in a recreational forest in forest visitors. We surveyed 220 volunteers attending guided walks before (n = 99) and after (n = 121) furnishing the Hallerwald. The questionnaire assessed restorative qualities of four places in the forest before and after furnishing, and changes in visitors’ self-perceptions pre and post visiting the forest for 2.5 h. Further, visitors evaluated the furniture and the visit. The four sites in the forest under study benefited differently from furnishing. We found mixed outcomes with respect to the restorative qualities of places by furnishing, and a similar improvement of human restoration pre- and post-walk, irrespective of furnishing, but received mainly positive ratings for the installed furniture. The participants expected positive effects of visiting the forest to last one to two days. Our findings suggest that furnishing the forest made this forest a unique place for pedagogy, health interventions, and tourism. We concluded that furnishing, designed to fit the characteristics of a specific place, can support health and well-being in restorative forests and should be recognized by sustainable forest management.
Forest Fire Patterns and Lightning-Caused Forest Fire Detection in Heilongjiang Province of China Using Satellite Data
Authors: Jiao Qiangying , Fan Meng , Tao Jinhua , Wang Weiye , Liu Di , Wang Ping
Published: April 2023

Large forest fires can cause significant damage to forest ecosystems and threaten human life and property. Heilongjiang Province is a major forested area in China with the highest number and concentration of lightning-caused forest fires in the country. This study examined the spatial and temporal distribution patterns of forest fires in Heilongjiang Province, as well as the ability of satellite remote sensing to detect these fires using VIIRS 375 m fire point data, ground history forest fire point data, and land cover dataset. The study also investigated the occurrence patterns of lightning-caused forest fires and the factors affecting satellite identification of these fires through case studies. Results show that April has the highest annual number of forest fires, with 77.6% of forest fires being caused by lightning. However, less than 30% of forest fires can be effectively detected by satellites, and lightning-caused forest fires account for less than 15% of all fires. There is a significant negative correlation between the two. Lightning-caused forest fires are concentrated in the Daxing’an Mountains between May and July, and are difficult to monitor by satellites due to cloud cover and lack of satellite transit. Overall, the trend observed in the number of forest fire pixels that are monitored by satellite remote sensing systems is generally indicative of the trends in the actual number of forest fires. However, lightning-caused forest fires are the primary cause of forest fires in Heilongjiang Province, and satellite remote sensing is relatively weak in monitoring these fires due to weather conditions and the timing of satellite transit.
Unlimited Sampling Theorem Based on Fractional Fourier Transform
Authors: Zhao Hui , Li Bing-Zhao
Published: April 2023

The recovery of bandlimited signals with high dynamic range is a hot issue in sampling research. The unlimited sampling theory expands the recordable range of traditional analog-to-digital converters (ADCs) arbitrarily, and the signal is folded back into a low dynamic range measurement, avoiding the saturation problem. Since the non-bandlimited signal in the Fourier domain cannot be directly applied to its existing theory, the non-bandlimited signal in the Fourier domain may be bandlimited in the fractional Fourier domain. Therefore, this brief report studies the unlimited sampling problem of high dynamic non-bandlimited signals in the Fourier domain based on the fractional Fourier transform. Firstly, a mathematical signal model for unlimited sampling is proposed. Secondly, based on this mathematical model, the annihilation filtering method is used to estimate the arbitrary folding time. Finally, a novel fractional Fourier domain unlimited sampling theorem is obtained. The theory proves that, based on the folding characteristics of the self-reset ADC, the number of samples is not affected by the modulo threshold, and any folding time can be handled.
Polycomb-like Proteins in Gene Regulation and Cancer
Authors: Fischer Sabrina , Liefke Robert
Published: April 2023

Polycomb-like proteins (PCLs) are a crucial group of proteins associated with the Polycomb repressive complex 2 (PRC2) and are responsible for setting up the PRC2.1 subcomplex. In the vertebrate system, three homologous PCLs exist: PHF1 (PCL1), MTF2 (PCL2), and PHF19 (PCL3). Although the PCLs share a similar domain composition, they differ significantly in their primary sequence. PCLs play a critical role in targeting PRC2.1 to its genomic targets and regulating the functionality of PRC2. However, they also have PRC2-independent functions. In addition to their physiological roles, their dysregulation has been associated with various human cancers. In this review, we summarize the current understanding of the molecular mechanisms of the PCLs and how alterations in their functionality contribute to cancer development. We particularly highlight the nonoverlapping and partially opposing roles of the three PCLs in human cancer. Our review provides important insights into the biological significance of the PCLs and their potential as therapeutic targets for cancer treatment.
Oxidative Damage and Post-COVID Syndrome: A Cross-Sectional Study in a Cohort of Italian Workers
Authors: Stufano Angela , Isgrò Camilla , Palese Luigi Leonardo , Caretta Paolo , De Maria Luigi , Lovreglio Piero , Sardanelli Anna Maria
Published: April 2023

In addition to the acute symptoms after infection, patients and society are also being challenged by the long-term effects of COVID-19, known as long COVID. Oxidative stress, as a pivotal point in the pathophysiology of COVID-19, could potentially be also involved in the development of the post-COVID syndrome. The aim of the present study was to evaluate the relationship between changes in oxidative status and the persistence of long-COVID symptoms in workers with a previous mild COVID-19 infection. A cross-sectional study was conducted among 127 employees of an Italian university (80 with a previous COVID-19 infection, and 47 healthy subjects). The TBARS assay was used to detect malondialdehyde serum levels (MDA), while total hydroperoxide (TH) production was measured by a d-ROMs kit. A significant difference in mean serum MDA values was found between previously infected subjects and healthy controls and (4.9 µm vs. 2.8 µm, respectively). Receiver–operating characteristic (ROC) curves showed high specificity and good sensibility (78.7% and 67.5%, respectively) for MDA serum levels. A random forest classifier identified the hematocrit value, MDA serum levels, and IgG titer against SARS-CoV-2 as features with the highest predictive value in distinguishing 34 long-COVID from 46 asymptomatic post-COVID subjects. Oxidative damage persists in subjects with previous COVID-19 infection, suggesting a possible role of oxidative stress mediators in the pathogenesis of long COVID.
Double Mutations in a Patient with Early-Onset Alzheimer’s Disease in Korea: An APP Val551Met and a PSEN2 His169Asn
Authors: Bae Heewon , Shim Kyu Hwan , Yoo Jang , Yang Young-Soon , An Seong Soo A. , Kang Min-Ju
Published: April 2023

The etiology of early-onset Alzheimer’s disease (EOAD) is associated with alterations in the production of amyloid beta (Aβ) species caused by mutations in the APP, PSEN1, and PSEN2 genes. Mutations affect intra- or inter-molecular interactions and processes between the γ-secretase complex and amyloid precursor protein (APP), leading to the aberrant sequential cleavage of Aβ species. A 64-year-old woman presented with progressive memory decline, mild right hippocampal atrophy, and a family history of Alzheimer’s dementia (AD). Whole exome sequencing was performed to evaluate AD-related gene mutations, which were verified by Sanger sequencing. A mutation-caused structural alteration of APP was predicted using in silico prediction programs. Two AD-related mutations, in APP (rs761339914; c.G1651A; p.V551M) and PSEN2 (rs533813519; c.C505A; p.H169N), were identified. The APP Val551Met mutation in the E2 domain may influence APP homodimerization through changes in intramolecular interactions between adjacent amino acids, altering Aβ production. The second mutation was PSEN2 His169Asn mutation, which was previously reported in five EOAD patients from Korea and China, with a relatively high frequency in the East Asian population. According to a previous report, the presenilin 2 protein was predicted to result in a major helical torsion by PSEN2 His169Asn mutation. Notably, the co-existence of APP Val551Met and PSEN2 His169Asn may induce a synergistic effect by both mutations. Future functional studies are needed to clarify the pathological effects of these double mutations.
Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome
Authors: Khan Muhammad Sohaib , Kim Hee-Sun , Kim Ranhee , Yoon Sang Ho , Kim Sang Geon
Published: April 2023

A significant fraction of couples around the world suffer from polycystic ovarian syndrome (PCOS), a disease defined by the characteristics of enhanced androgen synthesis in ovarian theca cells, hyperandrogenemia, and ovarian dysfunction in women. Most of the clinically observable symptoms and altered blood biomarker levels in the patients indicate metabolic dysregulation and adaptive changes as the key underlying mechanisms. Since the liver is the metabolic hub of the body and is involved in steroid-hormonal detoxification, pathological changes in the liver may contribute to female endocrine disruption, potentially through the liver-to-ovary axis. Of particular interest are hyperglycemic challenges and the consequent changes in liver-secretory protein(s) and insulin sensitivity affecting the maturation of ovarian follicles, potentially leading to female infertility. The purpose of this review is to provide insight into emerging metabolic mechanisms underlying PCOS as the primary culprit, which promote its incidence and aggravation. Additionally, this review aims to summarize medications and new potential therapeutic approaches for the disease.
Metabolic Reprogramming of HCC: A New Microenvironment for Immune Responses
Authors: Foglia Beatrice , Beltrà Marc , Sutti Salvatore , Cannito Stefania
Published: April 2023

Hepatocellular carcinoma is the most common primary liver cancer, ranking third among the leading causes of cancer-related mortality worldwide and whose incidence varies according to geographical area and ethnicity. Metabolic rewiring was recently introduced as an emerging hallmark able to affect tumor progression by modulating cancer cell behavior and immune responses. This review focuses on the recent studies examining HCC’s metabolic traits, with particular reference to the alterations of glucose, fatty acid and amino acid metabolism, the three major metabolic changes that have gained attention in the field of HCC. After delivering a panoramic picture of the peculiar immune landscape of HCC, this review will also discuss how the metabolic reprogramming of liver cancer cells can affect, directly or indirectly, the microenvironment and the function of the different immune cell populations, eventually favoring the tumor escape from immunosurveillance.
Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation
Authors: Wang Desheng , Gomes Marta T. , Mo Yanfei , Prohaska Clare C. , Zhang Lu , Chelvanambi Sarvesh , Clauss Matthias A. , Zhang Dongfang , Machado Roberto F. , Gao Mingqi , Bai Yang
Published: April 2023

Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human endogenous retrovirus K(HERV-K), and human immunodeficiency virus (HIV), in part due to acute and chronic inflammation. In this review, we discuss the connections between HERV-K, HIV, SARS-CoV-2, and PAH, to stimulate research regarding new therapeutic options and provide new targets for the treatment of the disease.
Biodegradable Polymers and Polymer Composites with Antibacterial Properties
Authors: Smola-Dmochowska Anna , Lewicka Kamila , Macyk Alicja , Rychter Piotr , Pamuła Elżbieta , Dobrzyński Piotr
Published: April 2023

Antibiotic resistance is one of the greatest threats to global health and food security today. It becomes increasingly difficult to treat infectious disorders because antibiotics, even the newest ones, are becoming less and less effective. One of the ways taken in the Global Plan of Action announced at the World Health Assembly in May 2015 is to ensure the prevention and treatment of infectious diseases. In order to do so, attempts are made to develop new antimicrobial therapeutics, including biomaterials with antibacterial activity, such as polycationic polymers, polypeptides, and polymeric systems, to provide non-antibiotic therapeutic agents, such as selected biologically active nanoparticles and chemical compounds. Another key issue is preventing food from contamination by developing antibacterial packaging materials, particularly based on degradable polymers and biocomposites. This review, in a cross-sectional way, describes the most significant research activities conducted in recent years in the field of the development of polymeric materials and polymer composites with antibacterial properties. We particularly focus on natural polymers, i.e., polysaccharides and polypeptides, which present a mechanism for combating many highly pathogenic microorganisms. We also attempt to use this knowledge to obtain synthetic polymers with similar antibacterial activity.
Dynamic Regulation of Lipid Droplet Biogenesis in Plant Cells and Proteins Involved in the Process
Authors: Zhao Yiwu , Dong Qingdi , Geng Yuhu , Ma Changle , Shao Qun
Published: April 2023

Lipid droplets (LDs) are ubiquitous, dynamic organelles found in almost all organisms, including animals, protists, plants and prokaryotes. The cell biology of LDs, especially biogenesis, has attracted increasing attention in recent decades because of their important role in cellular lipid metabolism and other newly identified processes. Emerging evidence suggests that LD biogenesis is a highly coordinated and stepwise process in animals and yeasts, occurring at specific sites of the endoplasmic reticulum (ER) that are defined by both evolutionarily conserved and organism- and cell type-specific LD lipids and proteins. In plants, understanding of the mechanistic details of LD formation is elusive as many questions remain. In some ways LD biogenesis differs between plants and animals. Several homologous proteins involved in the regulation of animal LD formation in plants have been identified. We try to describe how these proteins are synthesized, transported to the ER and specifically targeted to LD, and how these proteins participate in the regulation of LD biogenesis. Here, we review current work on the molecular processes that control LD formation in plant cells and highlight the proteins that govern this process, hoping to provide useful clues for future research.
Ribosome Specialization in Protozoa Parasites
Authors: Rodríguez-Almonacid Cristian Camilo , Kellogg Morgana K. , Karamyshev Andrey L. , Karamysheva Zemfira N.
Published: April 2023

Ribosomes, in general, are viewed as constitutive macromolecular machines where protein synthesis takes place; however, this view has been recently challenged, supporting the hypothesis of ribosome specialization and opening a completely new field of research. Recent studies have demonstrated that ribosomes are heterogenous in their nature and can provide another layer of gene expression control by regulating translation. Heterogeneities in ribosomal RNA and ribosomal proteins that compose them favor the selective translation of different sub-pools of mRNAs and functional specialization. In recent years, the heterogeneity and specialization of ribosomes have been widely reported in different eukaryotic study models; however, few reports on this topic have been made on protozoa and even less on protozoa parasites of medical importance. This review analyzes heterogeneities of ribosomes in protozoa parasites highlighting the specialization in their functions and their importance in parasitism, in the transition between stages in their life cycle, in the change of host and in response to environmental conditions.
Aeroacoustic Simulations of an Axial Fan with Modelled Turbulent Inflow Conditions
Authors: Dietrich Philipp , Schneider Marc
Published: April 2023

In applications, the acoustics of fans can differ significantly from the measurements of the standalone fan. This is due to disturbed inflow conditions, for example, caused by a heat exchanger upstream of an axial fan. Resolving the complex geometry and dimensions of typical heat exchangers in aeroacoustic scale-resolving simulations leads to a very high computation effort, which is currently not economically feasible. Turbulence reconstruction tools, such as the FRPM, provide the possibility to model the turbulent inflow conditions, thereby avoiding the representation of the heat exchanger in the aeroacoustic simulations. This approach is tested on a benchmark experiment of a ducted fan with an upstream turbulence grid.
Ventilators, Settings, Autotitration Algorithms
Authors: Luján Manel , Lalmolda Cristina
Published: April 2023

The choice of a ventilator model for a single patient is usually based on parameters such as size (portability), presence or absence of battery and ventilatory modes. However, there are many details within each ventilator model about triggering, pressurisation or autotitration algorithms that may go unnoticed, but may be important or may justify some drawbacks that may occur during their use in individual patients. This review is intended to emphasize these differences. Guidance is also provided on the operation of autotitration algorithms, in which the ventilator is able to take decisions based on a measured or estimated parameter. It is important to know how they work and their potential sources of error. Current evidence on their use is also provided.
Update on Shoulder Arthroplasties with Emphasis on Imaging
Authors: Weaver Jennifer , Omar Imran , Chadwick Nicholson , Shechtel Joanna , Elifritz Jamie , Shultz Christopher , Taljanovic Mihra
Published: April 2023

Shoulder pain and dysfunction may significantly impact quality of life. If conservative measures fail, advanced disease is frequently treated with shoulder arthroplasty, which is currently the third most common joint replacement surgery following the hip and knee. The main indications for shoulder arthroplasty include primary osteoarthritis, post-traumatic arthritis, inflammatory arthritis, osteonecrosis, proximal humeral fracture sequelae, severely dislocated proximal humeral fractures, and advanced rotator cuff disease. Several types of anatomic arthroplasties are available, such as humeral head resurfacing and hemiarthroplasties, as well as total anatomic arthroplasties. Reverse total shoulder arthroplasties, which reverse the normal ball-and-socket geometry of the shoulder, are also available. Each of these arthroplasty types has specific indications and unique complications in addition to general hardware-related or surgery-related complications. Imaging—including radiography, ultrasonography, computed tomography, magnetic resonance imaging, and, occasionally, nuclear medicine imaging—has a key role in the initial pre-operative evaluation for shoulder arthroplasty, as well as in post-surgical follow-up. This review paper aims to discuss important pre-operative imaging considerations, including rotator cuff evaluation, glenoid morphology, and glenoid version, as well as to review post-operative imaging of the various types of shoulder arthroplasties, to include normal post-operative appearances as well as imaging findings of complications.
Short-Term Effects of Specific Sensorimotor Training on Postural Assessment in Healthy Individuals: A Pilot Study with a Randomized Placebo-Controlled Trial
Authors: Di Corrado Donatella , Francavilla Vincenzo Cristian , La Paglia Rosamaria , Parisi Maria Chiara , Buscemi Andrea , Coco Marinella
Published: April 2023

It is well-known that sensorimotor training aims to increase the performance of the sensorimotor system to maintain an upright position. Through the use of a randomized placebo-controlled trial, the specific aim of this study was to investigate the short-term effects of a specific session of sensorimotor training on postural balance, stability and coordination in healthy, recreationally active participants. Ninety subjects were randomly allocated into three groups: experimental (n = 30), placebo (n = 32) and control (n = 28). The experimental group performed a 5 min warm-up, with the sensorimotor training consisting of 60-min specific sensorimotor exercises; the control group was not allowed to perform any sensorimotor training; the placebo group observed a video clip of an individual belonging to the experimental group performing the sensorimotor training accurately. All participants were seen three times per week for 4 weeks. Before and after the entire training, all groups of participants undertook stabilometric parameter assessment. The intervention-mediated sensorimotor training confirmed significant enhancement in the proprioceptive system. Significant improvement in the motor and/or sensory function was observed in the experimental and placebo groups. In conclusion, our findings suggest that specific sensorimotor training performed 3 days per week for 4 weeks could improve postural balance, stability and coordination in healthy individuals.
A Novel Risk Calculator to Predict Erectile Dysfunction in HIV-Positive Men
Authors: Chirca Narcis , Streinu-Cercel Anca , Stefan Marius , Aurelian Justin , Persu Cristian
Published: April 2023

HIV infection is considered to be a lifelong medical condition, requiring follow-up and treatment for decades. HIV-positive men are reported to have erectile dysfunction more often than age-matched healthy controls, and improving sexuality is known to potentially improve overall health-related quality of life. The aim of this paper is to evaluate the presence of ED in HIV-positive men and the associated contributing factors and to create a statistical model to assess the risk to develop ED in this population. In a prospective study, we analyzed a group of HIV-positive men in a cross-sectional manner, looking at demographics, blood test results, and smoking habits. Data were statistically analyzed using the Kruskal–Wallis test. In our series, the overall incidence of ED was 48.5%, increasing with age. Our analysis showed no correlation with blood sugar level, but a very strong correlation with total serum lipids. We were able to develop and validate a risk calculator for ED in HIV-positive men.
Digital Platforms and Supply Chain Traceability for Robust Information and Effective Inventory Management: The Mediating Role of Transparency
Authors: Khan Muhammad , Alshahrani Amal Nasser , Jacquemod Julija
Published: April 2023

Background: This article’s main goal is to examine how digital platforms and supply chain traceability (SCT) might contribute to robust information and efficient inventory management (EIM); Methods: SmartPLS3 software was used in conjunction with the partial least squares structural equation modeling (PSL-SEM) technique. Using the snowball sampling method, the software was used to collect data from Pakistani supply chain (SC) specialists; Results: According to this study’s conclusions, robust information and inventory management using digital platforms and SC traceability depend greatly on transparency; Conclusions: Even though investing in digital platforms is a complex process including multiple internal and external parties, this study will be helpful for the decision-makers who make such decisions. The paper identifies research gaps and presents the potential for more research while also increasing awareness of digital platforms, traceability, and transparency in the SC system. There is a shortage of empirical evidence on how digital platforms and SCT lead to robust information and EIM through the mediation association of transparency, notwithstanding the abundance of research conducted on SCT and transparency.
Epidemiological Investigation of Pediatric Fractures—A Retrospective Cohort Study of 1129 Patients
Authors: Xiao Xiaoliang , Ding Yuhong , Zheng Yiqiu , Gao Yun , Li Huaqing , Liu Ruikang , Xu Ruijing , Hong Pan
Published: April 2023

Background and Objectives: Fractures are common in pediatric trauma, and they are caused by a broad spectrum of factors. Only a few studies have discussed the mechanisms of injury and their relationships to different types of fractures. The most frequent type of fractures in different age groups remains unclear. Therefore, we aim to summarize the epidemiological characteristics of pediatric fractures in a medical center in Zhuhai, China from 2006 to 2021 and analyze the causes of fractures with the highest frequency in different age groups. Materials and Methods: We extracted the information from the Zhuhai Center for Maternal and Child Health Care of those under 14 years old who had fractures from 2006 to 2021. Results: We reviewed the information of 1145 children. The number of patients increased during the 15 years (p < 0.0001). The number of patients was significantly different between genders after Y2 (p = 0.014). In addition, more than two-thirds of patients (71.3%) had upper limb fractures, and all types of falls were the most common cause of fractures (83.6%). The incidence demonstrated an insignificant difference in age groups except for the fractures of humerus and radius. Moreover, we discovered that the prevalence of fall-related injuries decreased with age, while that of sports-related injuries increased with age. Conclusions: Our study demonstrates that the prevalence of fall-related injuries decreases with age, and that of sports-related injuries increases with age. Most patients have upper limb fractures, and all types of falls are the most common cause of fractures. Fracture types with the highest frequency differ in each age group. These findings might supplement current epidemiological knowledge of childhood fracture and provide references for decision-making in children’s health policies.
The Promise of Artificial Intelligence in Digestive Healthcare and the Bioethics Challenges It Presents
Authors: Mascarenhas Miguel , Afonso João , Ribeiro Tiago , Andrade Patrícia , Cardoso Hélder , Macedo Guilherme
Published: April 2023

With modern society well entrenched in the digital area, the use of Artificial Intelligence (AI) to extract useful information from big data has become more commonplace in our daily lives than we perhaps realize. Medical specialties that rely heavily on imaging techniques have become a strong focus for the incorporation of AI tools to aid disease diagnosis and monitoring, yet AI-based tools that can be employed in the clinic are only now beginning to become a reality. However, the potential introduction of these applications raises a number of ethical issues that must be addressed before they can be implemented, among the most important of which are issues related to privacy, data protection, data bias, explainability and responsibility. In this short review, we aim to highlight some of the most important bioethical issues that will have to be addressed if AI solutions are to be successfully incorporated into healthcare protocols, and ideally, before they are put in place. In particular, we contemplate the use of these aids in the field of gastroenterology, focusing particularly on capsule endoscopy and highlighting efforts aimed at resolving the issues associated with their use when available.
The Dilemma of Balance between Benefits and Losses for Chondromyxoid Fibroma-like Osteosarcoma in Thoracic Spine with Azygos Tumor Thrombosis: A Case Report
Authors: Du Chuanchao , Liu Xiaoguang , Liu Zhongjun , Wei Feng
Published: April 2023

Background: Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is an extremely rare subtype of osteosarcoma, its clinical data are scarce, and our understanding of it is far from sufficient. As it has few typical imaging manifestations, it is not uncommonly misdiagnosed clinically. Azygos vein thrombosis is also a rare entity, and there is a big controversy over treatments for it. Case presentation: Herein, we report a case of CMF-OS that occurred in the spine, coincidently, azygos vein thrombosis was found. A young male patient came to our clinic because of continuous back pain, and a neoplastic lesion was suspected in the thoracolumbar vertebrae. The pathological results of the biopsy showed a low grade of osteosarcoma, and chondromyxoid fibroma-like osteosarcoma was the primary diagnosis. Since the tumor cannot be en-bloc resected, he received palliative decompression surgery, followed by radio and chemotherapy. Azygos vein tumor thrombosis was not treated and, unfortunately, he died of heart failure caused by the thrombus migrating from the azygos vein to the right atrium. Before the palliative decompression surgery, both the patient and the clinical team were trapped in the dilemma of how big a surgery should be carried out to maximize the benefits of this patient. Results and complications: CMF-OS is indeed more aggressive than its pathological sections suggest. Guidelines for osteosarcoma should be followed. Furthermore, it is important to recognize the danger of tumor thrombosis in the azygos vein. Preventive measures have to be performed in a timely manner to avoid catastrophic results.
Hydrophobic Modified Ceramic Aeration Membrane for Effective Treatment of Brine Wastewater
Authors: Xu Xinqiang , Zhang Hua , Jin Jiang
Published: April 2023

A novel approach to evaporate brine wastewater using a ceramic aeration membrane was proposed. A high-porosity ceramic membrane was selected as the aeration membrane and was modified with hydrophobic modifiers to avoid undesired surface wetting. The water contact angle of the ceramic aeration membrane reached 130° after hydrophobic modification. The hydrophobic ceramic aeration membrane showed excellent operational stability (up to 100 h), high salinity (25 wt.%) tolerance, and excellent regeneration performance. The evaporative rate reached 98 kg m−2 h−1, which could be restored by ultrasonic cleaning after the membrane fouling occurred. Furthermore, this novel approach shows great promise for practical applications toward a low cost of only 66 kW·h·m−3.
Evaluating Strategies to Increase the Number of Women Working in the UK Surveying Profession
Authors: Clarkson Sinéad , Hind Lucy , Zulu Sambo
Published: April 2023

The surveying profession in the UK construction industry continues to be blighted by a skills shortage, and this continues to constrict growth. Therefore, it is suggested that this should make it easier for women and other underrepresented groups to be employed in the construction industry. While this is the case, barriers to entry have been well researched. This study aimed to identify what methods have been previously successful at increasing female engagement within the surveying profession in the UK. This study followed a mixed-method, complementary approach, combining quantitative and qualitative questions in an online questionnaire, which was distributed via social media (LinkedIn) and the researchers’ contacts, and achieved 44 responses over a period of six weeks. The target population was female UK residents employed in surveying roles. Quantitative data on both awareness and opinion of the methods used during previous initiatives to engage women with surveying underwent reliability analysis, descriptive statistical analysis, and a Spearman’s rank order correlation to assess the relationship between time in industry and opinion on the efficacy of the methods used in each initiative; however, no statistically significant relationship was found. To better understand the opinions of women already in the industry, the qualitative data underwent thematic analysis via inductive coding, the results of which then underwent descriptive statistical analysis. The study found a broad lack of awareness of previous initiatives, with most respondents having little or no awareness of the five initiatives examined. However, evidence suggested there was general support for the methods used in those initiatives, such as intervention at school age, increasing the visibility of women in surveying roles, and changes to workplace culture. There was no statistically significant link between time in industry and opinion on the efficacy of each initiative. Key themes included concerns regarding the implementation of current initiatives, and enthusiasm for intervention at school age as the best method to engage more women with the surveying profession. The findings have implications for both practice and future research. First, professional institutions, such as the Royal Institution of Chartered Surveyors, should be aware of the limitations of the initiatives they put in place to encourage women into their profession. Second, the results have an impact on other professions. However, a cross-comparative study that examines initiatives by other professional institutions would be useful.
Description of the New Eutectic Al-Ca-Cu System in the Aluminum Corner
Authors: Akopyan Torgom K. , Belov Nikolay A. , Letyagin Nikolay V. , Cherkasov Stanislav O. , Nguen Xuan D.
Published: April 2023

The structure of the new ternary eutectic Al-Ca-Cu system considered as a replacement for the ternary eutectic system Al-Ce-Cu widely used for additive manufacturing has been studied using experimental techniques. The liquidus projection of the Al-Ca-Cu system in the aluminum corner has been suggested based on experiential studies of the microstructure and phase composition of model alloys. The suggested structure of the diagram has two quasi-binary sections: (Al)-Al27Ca3Cu7 and (Al)-Al8CaCu4 and three invariant eutectic transformations: L→(Al) + (Al,Cu)4Ca + Al27Ca3Cu7 (at 5.6 wt.% Ca, 4.5 wt.% Cu, 595 °C), L→(Al) + Al27Ca3Cu7 + Al8CaCu4 (at 2.2 wt.% Ca, 13.5 wt.% Cu, 594 °C) and L→(Al) + Al8CaCu4 + Al2Cu (at 0.5 wt.% Ca, 34 wt.% Cu, 544 °C). The limit solubility of copper in aluminum solid solution (Al) at 530 °C reaches ~5.1 wt.% in the ternary phase field (Al) + Al8CaCu4 + Al2Cu and drops to ~2.4 wt.% in the (Al) + Al8CaCu4 + Al27Ca3Cu7 ternary phase field. For the example of the model ternary hypoeutectic alloys with a predominant content of the eutectic (Al,Cu)4Ca phase, it has been shown that the system is promising for designing new eutectic-type alloys with a natural composite structure.
Study of the Metabolic Profiles of “Indazole-3-Carboxamide” and “Isatin Acyl Hydrazone” (OXIZID) Synthetic Cannabinoids in a Human Liver Microsome Model Using UHPLC-QE Orbitrap MS
Authors: Xiang Jiahong , Wen Di , Zhao Junbo , Xiang Ping , Shi Yan , Ma Chunling
Published: April 2023

Unregulated core structures, “isatin acyl hydrazones” (OXIZIDs), have quietly appeared on the market since China legislated to ban seven general core scaffolds of synthetic cannabinoids (SCs). The fast evolution of SCs presents clinical and forensic toxicologists with challenges. Due to extensive metabolism, the parent compounds are barely detectable in urine. Therefore, studies on the metabolism of SCs are essential to facilitate their detection in biological matrices. The aim of the present study was to elucidate the metabolism of two cores, “indazole-3-carboxamide” (e.g., ADB-BUTINACA) and “isatin acyl hydrazone” (e.g., BZO-HEXOXIZID). The in vitro phase I and phase II metabolism of these six SCs was investigated by incubating 10 mg/mL pooled human liver microsomes with co-substrates for 3 h at 37 °C, and then analyzing the reaction mixture using ultrahigh-performance liquid chromatography-quadrupole/electrostatic field orbitrap mass spectrometry. In total, 9 to 34 metabolites were detected for each SC, and the major biotransformations were hydroxylation, dihydrodiol formation (MDMB-4en-PINACA and BZO-4en-POXIZID), oxidative defluorination (5-fluoro BZO-POXIZID), hydrogenation, hydrolysis, dehydrogenation, oxidate transformation to ketone and carboxylate, N-dealkylation, and glucuronidation. Comparing our results with previous studies, the parent drugs and SC metabolites formed via hydrogenation, carboxylation, ketone formation, and oxidative defluorination were identified as suitable biomarkers.
Evolution, Magmatic Source and Metallogenesis of A-Type Granites in the Fanchang Volcanic Basin, Middle and Lower Yangtze Metallogenic Belt: A Review
Authors: Zhang Songsong , Yang Xiaoyong , Liu Lei
Published: April 2023

The Fanchang volcanic basin (FVB) is located in the Middle and Lower Yangtze Metallogenic Belt (MLYMB) between the ore districts of Ningwu and Tongling. The existing ore deposits in the FVB are relatively small in scale and related to late Mesozoic A-type granites. In this paper, the crystallization age, major and trace element composition, and Sr-Nd and Hf isotope compositions of the A-type granites are summarized from the literature; in addition, the magnetite composition, H and O isotopes of fluid inclusions, and sulfur isotope composition of metal sulfides in some typical ore deposits in the FVB are also summarized to give insights into the petrogenesis and mineralization of the A-type granites intruding into the FVB. The results show that: (1) Orthopyroxene, plagioclase, K-feldspar, and biotite are the main fractionating minerals controlling the evolution of the magmas of A-type granites in the FVB and other areas in the MLYMB. (2) The whole-rock Sr-Nd and zircon Hf isotopic characteristics show that the source of A-type granite magma is complex and includes the enriched mantle, lower crust, and upper crust, probably with stronger participation of Archaean–Paleoproterozoic crustal materials in the FVB granites than in other regions of the MLYMB. (3) The ores in the FVB are dominated by skarn and hydrothermal deposits. H and O isotopes of fluid inclusions indicate that ore-forming fluids have been derived from mixtures of magmatic hydrothermal fluid, meteoric waters, and deep brine related to gypsum layers. S isotopes of metal sulfides indicate that the sulfur may be a mixture of magmatically derived sulfur and sulfur originating from the Triassic gypsum-bearing layers. The deposit and ore characteristics of the main deposits in the FVB are also illustrated, and the evaluation of metal resources indicates that the skarn and hydrothermal iron–zinc ores in the FVB also have potential as sources of Cd, Ga, and Se. In addition, in terms of the oxygen fugacity, rock type, and geochemical characteristics of magmatic rocks, the metallogenic characteristics and potential of the A-type granites in the FVB are evaluated. It is considered that in addition to the dominant constituents of iron and zinc and the minor constituents listed above, the FVB could have the potential for providing copper, gold, molybdenum, uranium, and other metals as well.
Bioactive Compounds and Antioxidant Composition of Nut Bars with Addition of Various Edible Insect Flours
Authors: Gumul Dorota , Oracz Joanna , Kowalski Stanisław , Mikulec Anna , Skotnicka Magdalena , Karwowska Kaja , Areczuk Anna
Published: April 2023

Edible insects represent a new functional source of nutrients that can contribute to solving nutritional deficiency problems. The antioxidant potential and bioactive compounds of nut bars with the addition of three edible insects were evaluated. Acheta domesticus L., Alphitobius diaperinus P. and Tenebrio molitor L. flours were used. A 30% share of insect flour in the bars resulted in significantly greater antioxidant activity (TPC increased from 190.19 for standard bars to 309.45 mg catechin/100 g for bars with 30% addition of cricket flour). Insect flour contributed significantly to an increase in 2,5-dihydrobenzoic acid (from 0.12 for bars with a 15% share of buffalo worm flour to 0.44 mg/100 g in the case of bars with a 30% share of cricket flour) and chlorogenic acid in all bars (from 0.58 for bars with a 15% share of cricket flour to 3.28 mg/100 g for bars with a 30% addition of buffalo worm flour), compared to the standard. The highest content of tocopherols was found in bars with cricket flour, compared to standard bars (43.57 and 24.06 mg/100 g of fat, respectively). The dominant sterol in bars enriched with insect powder was cholesterol. The highest amount of it was found in cricket bars, and the lowest in mealworm bars (64.16 and 21.62 mg/100 g of fat, respectively). The enrichment of nut bars with insect flours raises the levels of valuable phytosterols in the final product. The addition of edible insect flours reduced the perception of most sensory attributes of the bars, compared to the standard bar.
Systematic Studies on Anti-Cancer Evaluation of Stilbene and Dibenzo[b,f]oxepine Derivatives
Authors: Borys Filip , Tobiasz Piotr , Poterała Marcin , Fabczak Hanna , Krawczyk Hanna , Joachimiak Ewa
Published: April 2023

Cancer is one of the most common causes of human death worldwide; thus, numerous therapies, including chemotherapy, have been and are being continuously developed. In cancer cells, an aberrant mitotic spindle—a microtubule-based structure necessary for the equal splitting of genetic material between daughter cells—leads to genetic instability, one of the hallmarks of cancer. Thus, the building block of microtubules, tubulin, which is a heterodimer formed from α- and β-tubulin proteins, is a useful target in anti-cancer research. The surface of tubulin forms several pockets, i.e., sites that can bind factors that affect microtubules’ stability. Colchicine pockets accommodate agents that induce microtubule depolymerization and, in contrast to factors that bind to other tubulin pockets, overcome multi-drug resistance. Therefore, colchicine-pocket-binding agents are of interest as anti-cancer drugs. Among the various colchicine-site-binding compounds, stilbenoids and their derivatives have been extensively studied. Herein, we report systematic studies on the antiproliferative activity of selected stilbenes and oxepine derivatives against two cancer cell lines—HCT116 and MCF-7—and two normal cell lines—HEK293 and HDF-A. The results of molecular modeling, antiproliferative activity, and immunofluorescence analyses revealed that compounds 1a, 1c, 1d, 1i, 2i, 2j, and 3h were the most cytotoxic and acted by interacting with tubulin heterodimers, leading to the disruption of the microtubular cytoskeleton.
HPAEC-PAD Analytical Evaluation of Carbohydrates Pattern for the Study of Technological Parameters Effects in Low-FODMAP Food Production
Authors: Pitirollo Olimpia , Grimaldi Maria , Corradini Claudio , Pironi Serena , Cavazza Antonella
Published: April 2023

Background: “FODMAPs” (fermentable-oligo-, di-, monosaccharides, and polyols) are a group of fermentable carbohydrates and polyols largely diffused in food products. Despite their beneficial effects as prebiotics, people affected by irritable bowel syndrome manifest symptoms when eating these carbohydrates. A low-FODMAP diet seems to be the only possible therapy proposed for symptom management. Bakery products are a common source of FODMAPs, whose pattern and total amount can be affected by their processing. This work aims at studying some of the technological parameters that can influence the FODMAPs pattern in bakery products during the production process. Methods: high-performance anion exchange chromatography coupled to a pulsed amperometric detector (HPAEC-PAD) was used as a highly selective system for carbohydrates evaluation analyses on flours, doughs, and crackers. These analyses were performed using two different columns, the CarboPac PA200 and CarboPac PA1, which are selective for oligosaccharide and simple sugar separation, respectively. Results: emmer and hemp flours were selected to prepare doughs as they contained low oligosaccharide content. Two different mixes of ferments were used at different times of fermentation to evaluate the best conditions to achieve low-FODMAP crackers. Conclusion: the proposed approach allows carbohydrate evaluation during crackers processing and permits the selection of opportune conditions to obtain low-FODMAP products.