bluuebunny/crossref_metadata_2025 huggingface dataset:
Two- and three-dimensional elastic networks with rigid junctions: modeling within the theory of micropolar shells and solids
Authors: Eremeyev Victor A.
Published: October 2019

For two- and three-dimensional elastic structures made of families of flexible elastic fibers undergoing finite deformations, we propose homogenized models within the micropolar elasticity. Here we restrict ourselves to networks with rigid connections between fibers. In other words, we assume that the fibers keep their orthogonality during deformation. Starting from a fiber as the basic structured element modeled by the Cosserat curve beam model, we get 2D and 3D semi-discrete models. These models consist of systems of ordinary differential equations describing the statics of a collection of fibers with certain geometrical constraints. Using a specific homogenization technique, we introduce two- and three-dimensional equivalent continuum models which correspond to the six-parameter shell model and the micropolar continuum, respectively. We call two models equivalent if their approximations coincide with each other up to certain accuracy. The two- and three-dimensional constitutive equations of the networks are derived and discussed within the micropolar continua theory.
Long-term oncological results after transanal total mesorectal excision for rectal carcinoma
Authors: Hol Jeroen C. , van Oostendorp Stefan E. , Tuynman Jurriaan B. , Sietses Colin
Published: October 2019

Background

Transanal total mesorectal excision (TaTME) for mid and low rectal cancer has been shown to improve short-term outcomes, mostly due to lower conversion rates and with improved quality of the specimen. However, robust long-term oncological data supporting the encouraging clinical and pathological outcomes are lacking.

Methods

All consecutive patients undergoing TaTME with curative intent for mid or low rectal cancer in two referral centers in The Netherlands between January 2012 and April 2016 with a complete and minimum follow-up of 36 months were included. The primary outcome was local recurrence rate. Secondary outcomes were disease-free survival, overall survival and development of metastasis.

Results

There were 159 consecutive patients. Their mean age was 66.9 (10.2) years and 66.7% of all patients were men. Pathological analysis showed a complete mesorectum in 139 patients (87.4%), nearly complete in 16 (10.1%) and an incomplete mesorectum in 4 (2.5%). There was involvement of the CRM (< 1 mm) in one patient (0.6%) and no patients had involvement of the distal margin (< 5 mm). Final postoperative staging after neoadjuvant therapy was stage 0 in 11 patients (6.9%), stage I in 73 (45.9%), stage II in 31 (19.5%), stage III in 37 (23.3%) and stage IV in 7 (4.4%). The 3-year local recurrence rate was 2.0% and the 5-year local recurrence rate was 4.0%. Median time to local recurrence was 19.2 months. Distant metastases were found in 22 (13.8%) patients and were diagnosed after a median of 6.9 months (range 1.1–50.4) months. Disease-free survival was 92% at 3 years and 81% at 5 years. Overall survival was 83.6% at 3 years and 77.3% at 5 years.

Conclusions

The long-term follow-up of the current cohort confirms the oncological safety and feasibility of TaTME in two high volume referral centers for rectal carcinoma. However, further robust and audited data must confirm current findings before widespread implementation of TaTME.
Identification of a novel locus, BPH38(t), conferring resistance to brown planthopper (Nilaparvata lugens Stal.) using early backcross population in rice (Oryza sativa L.)
Authors: Balachiranjeevi C. H. , Prahalada G. D. , Mahender A. , Jamaloddin Md. , Sevilla M. A. L. , Marfori-Nazarea C. M. , Vinarao R. , Sushanto U. , Baehaki S. E. , Li Z. K. , Ali J.
Published: October 2019

Rice is the most important staple food crop, and it feeds more than half of the world population. Brown planthopper (BPH) is a major insect pest of rice that causes 20–80% yield loss through direct and indirect damage. The identification and use of BPH resistance genes can efficiently manage BPH. A molecular marker-based genetic analysis of BPH resistance was carried out using 101 BC1F5mapping population derived from a cross between a BPH-resistantindicavariety Khazar and an elite BPH-susceptible line Huang–Huan–Zhan. The genetic analysis indicated the existence of Mendelian segregation for BPH resistance. A total of 702 high-quality polymorphic single nucleotide polymorphism (SNP) markers, genotypic data, and precisely estimated BPH scores were used for molecular mapping, which resulted in the identification of theBPH38(t) locus on the long arm of chromosome 1 between SNP markers 693,369 and id 10,112,165 of 496.2 kb in size with LOD of 20.53 and phenotypic variation explained of 35.91%. A total of 71 candidate genes were predicted in the detected locus. Among these candidate genes,LOC_Os01g37260was found to belong to the FBXL class of F-box protein possessing the LRR domain, which is reported to be involved in biotic stress resistance. Furthermore, background analysis and phenotypic selection resulted in the identification of introgression lines (ILs) possessing at least 90% recurrent parent genome recovery and showing superior performance for several agro-morphological traits. The BPH resistance locus and ILs identified in the present study will be useful in marker-assisted BPH resistance breeding programs.
Particles Do Not Conspire
Authors: Shahvisi Arianne
Published: October 2019

The aim of this paper is to debunk the assertion that miraculous “conspiracies” between fundamental particles are required to bring about the projectibility of special science generalisations. Albert and Loewer have proposed a theory of lawhood which supplements the Best System of fundamental laws with a statistical postulate over the initial conditions of the universe, thereby rendering special science generalisations highly probable, and dispelling the conspiracy. However, concerns have been raised about its ability to confer typicality upon special science generalisations in the way that is required. In this paper I defend their account against these charges, arguing that they derive from a misunderstanding of the typicality claim. I suggest a way out of the impasse via a naturalised approach which focusses on the genealogy of subsystems and encourages conceptual demonstrations of typicality for special science generalisations. I argue for an account of special science laws that acknowledges the way in which the special sciences reduce to the fundamental physics, thereby dissolving the conspiracy, yet respects the methodological and explanatory autonomy of special science generalisations.
Job assignment in large-scale service systems with affinity relations
Authors: Cardinaels Ellen , Borst Sem C. , van Leeuwaarden Johan S. H.
Published: October 2019

We consider load balancing in service systems with affinity relations between jobs and servers. Specifically, an arriving job can be assigned to a fast, primary server from a particular selection associated with this job or to a secondary server to be processed at a slower rate. Such job–server affinity relations can model network topologies based on geographical proximity, or data locality in cloud scenarios. We introduce load balancing schemes that assign jobs to primary servers if available, and otherwise to secondary servers. A novel coupling construction is developed to obtain stability conditions and performance bounds. We also conduct a fluid limit analysis for symmetric model instances, which reveals a delicate interplay between the model parameters and load balancing performance.
Recognition motifs rather than phylogenetic origin influence the ability of targeting peptides to import nuclear-encoded recombinant proteins into rice mitochondria
Authors: Baysal Can , Pérez-González Ana , Eseverri Álvaro , Jiang Xi , Medina Vicente , Caro Elena , Rubio Luis , Christou Paul , Zhu Changfu
Published: October 2019

Mitochondria fulfil essential functions in respiration and metabolism as well as regulating stress responses and apoptosis. Most native mitochondrial proteins are encoded by nuclear genes and are imported into mitochondria via one of several receptors that recognize N-terminal signal peptides. The targeting of recombinant proteins to mitochondria therefore requires the presence of an appropriate N-terminal peptide, but little is known about mitochondrial import in monocotyledonous plants such as rice (Oryza sativa). To gain insight into this phenomenon, we targeted nuclear-encoded enhanced green fluorescent protein (eGFP) to rice mitochondria using six mitochondrial pre-sequences with diverse phylogenetic origins, and investigated their effectiveness by immunoblot analysis as well as confocal and electron microscopy. We found that the ATPA and COX4 (Saccharomyces cerevisiae), SU9 (Neurospora crassa), pFA (Arabidopsis thaliana) and OsSCSb (Oryza sativa) peptides successfully directed most of the eGFP to the mitochondria, whereas the MTS2 peptide (Nicotiana plumbaginifolia) showed little or no evidence of targeting ability even though it is a native plant sequence. Our data therefore indicate that the presence of particular recognition motifs may be required for mitochondrial targeting, whereas the phylogenetic origin of the pre-sequences probably does not play a key role in the success of mitochondrial targeting in dedifferentiated rice callus and plants.
Improvement of the Ti-6Al-4V Alloy’s Tribological Properties and Electrochemical Corrosion Resistance by Nanocomposite TiN/PEEK708 Coatings
Authors: Moskalewicz Tomasz , Warcaba Maciej , Zimowski Sławomir , Łukaszczyk Alicja
Published: October 2019

In this work, polyetheretherketone-based TiN/PEEK708 nanocomposite coatings on oxygen hardened Ti-6Al-4V titanium alloy substrates were fabricated by using cathodic electrophoretic deposition and post-heat treatment. The microstructure of coatings was investigated by using scanning electron microscopy, transmission electron microscopy, and X-ray diffractometry. The scratch resistance, tribological properties, and electrochemical corrosion resistance were also studied. The results show that homogeneous TiN/PEEK708 coatings may be deposited from ethanol-based suspensions containing cationic chitosan polyelectrolyte, which provides electrosteric stabilization of the suspension. Heat treatment densified the coatings and changed the PEEK structure from amorphous to semi-crystalline. The coatings were characterized by very good scratch resistance, with no cohesive and adhesive cracks being observed up to the load of 30 N. They reduced the coefficient of friction from 0.70 for the baseline alloy and 0.65 for the oxygen hardened alloy to 0.30. They also significantly increased the wear resistance of the alloy during dry sliding contact with an alumina ball. The wear rate of the coated oxygen hardened alloy was about 70 and 650 times lower in comparison with the oxygen hardened and baseline alloy, respectively. The corrosion studies demonstrated that the baseline and oxygen hardened alloy have comparable corrosion resistance. The TiN/PEEK708 coating enhanced the electrochemical corrosion resistance of the alloy in the NaCl aqueous solution.
Brain glucose uptake during transcranial direct current stimulation measured with functional [18F]FDG-PET
Authors: Kraus Christoph , Hahn Andreas , Sigurdardottir Helen , Spurny Benjamin , Wadsak Wolfgang , Mitterhauser Markus , Hacker Marcus , Kasper Siegfried , Lanzenberger Rupert
Published: October 2019

Previous evidence indicates that transcranial direct stimulation (tDCS) is a neuromodulatory brain stimulation technique. Easy applicability, low side-effects and negligible costs facilitated its wide–spread application in efforts to modulate brain function, however neuronal mechanisms of tDCS are insufficiently understood. Hence, we investigated the immediate impact of tDCS on the brain’s glucose consumption in a continuous infusion protocol with the radioligand 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) and positron emission tomography (PET). This novel functional PET (fPET) method is capable to reliably detect area-specific and dynamic absolute glucose demand related to neuronal activity in a single molecular imaging session. Fifteen healthy subjects underwent tDCS at 0.5, 1 and 2 mA (mA) at the bilateral dorsolateral prefrontal cortex (dlPFC, cathodal right) for 10 min during functional [18F]FDG-PET lasting 70 min. Active stimulation compared to sham did not yield significant changes in glucose consumption at any tested stimulation intensity in this paradigm. Exploratory investigation of aftereffects provided hints for increased glucose consumption with a delay of 5 min at 1 mA in the right posterior temporal cortex. This is the first study investigating changes of glucose consumption in the brain during tDCS. The lack of immediately increased glucose consumption indicates that energy demanding processes in the brain such as glutamatergic signaling might not be immediately increased by tDCS. However, our results implicate the need of fPET investigations for medium-term and long-term effects.
The causes of stage expansion of WTI/Brent spread
Authors: Tian Hong-Zhi , Lai Wei-Di
Published: October 2019

Historically, the price of WTI crude oil futures has long been higher than that of Brent by $2/barrel, but the spread between 2011 and 2015 was reversed and expanded to $24/barrel. In order to analyze the difference between two crude oil price variables with the same trend and phase separation using one method of analysis, this paper constructs a dynamic comparative analysis framework using the method of time-point decomposition of fluctuation factors to determine the different reasons and amplitudes for monthly fluctuations in the two price systems in the sample interval. The study found that the sensitive response of Brent futures price indicators to the world’s crude oil supply resulting from the depletion of oil in the North Sea oil field prompted it to rise in 2011–2015. For the WTI price system, due to the increase in the US shale oil production after 2008 and the restrictions in domestic pipeline transportation capacity, the increase in the Cushing crude oil inventory caused downward pressure on the WTI price. With the lifting of the US crude oil export ban in December 2015, arbitrage space disappeared, and the spread between the two gradually narrowed.
An improved method for obtaining rotational accelerations from instrumented headforms
Authors: Nevins Derek , Smith Lloyd , Petersen Philip
Published: October 2019

The following compares the effect of differentiation methods used to acquire angular acceleration from three types of un-helmeted headform impact tests. The differentiation methods considered were the commonly used 5-point stencil method and a total variation regularization method. Both methods were used to obtain angular acceleration by differentiating angular velocity measured by three angular rate sensors (gyroscopes), and a reference angular acceleration signal was obtained from an array of nine linear accelerometers (that do not require differentiation to obtain angular acceleration). For each impact, three injury criteria that use angular acceleration as an input were calculated from the three angular acceleration signals. The effect of the differentiation methods were considered by comparing the criteria values obtained from gyroscope data to those obtained from the reference signal. Agreement with reference values was observed to be greater for the TV method when a user-defined tuning parameter was optimized for the impact test and cutoff frequency of each condition, particularly at higher cutoff frequencies. In this case, mean absolute error of the five-point stencil ranged from 1.0 (the same) to 11.4 times larger than that associated with the TV method. When a constant tuning parameter value was used across all impacts and cutoff frequencies considered in this study, the TV method still provided a significant improvement over the 5-point stencil method, achieving mean absolute errors as low as one-tenth that observed for the five-point stencil method.
High Altitude Legality: Visuality and Jurisdiction in the Adjudication of NATO Air Strikes
Authors: Wilke Christiane
Published: October 2019

Air strikes are the signature modality of violence used by NATO militaries. When civilian victims of NATO air strikes have turned to courts in NATO countries, they have generally not been successful. What are the legal techniques and legal knowledges deployed in Western courts that render Western aerial violence legal or extralegal? The article analyzes the responses by European courts to two sets of NATO bombings: the 1999 bombing of Yugoslavia and a September 2009 air strike near Kunduz, Afghanistan. The judgments rely on two forms of “legal technicalities”: the drawing of jurisdictional boundaries that exclude the airspace taken up by the bombers and the ground on which victims stood when they were killed as well as particular visual regimes that facilitate not seeing people on the ground as civilians.
Le tournant sensoriel en droit : vers un droit sensible et sensé?
Authors: Antaki Mark
Published: October 2019

Le tournant sensoriel en droit nous invite à vivre différemment le droit en reconnaissant la centralité de tous nos sens dans l’étude et la pratique d’une vocation qui nous appelle à la quête de sens. Il vise à renverser l’anesthésie générale qui afflige les études en droit, et en droit et société : la juridicité elle-même, c’est-à-dire l’essence du droit – les sens du droit – est une question sensorielle et sensuelle.
Contraceptive use and its effect on Indian women’s empowerment: evidence from the National Family Health Survey-4
Authors: Dhak Biplab , Saggurti Niranjan , Ram Faujdar
Published: October 2019

The positive effect of women’s empowerment on the use of contraceptives is well established. However, the reverse effect, i.e. the potential effect of use of contraceptives on women’s empowerment, is relatively unexplored. This study examined the direct impact of contraceptive use on women’s empowerment in currently married women aged 15–49 years in India using data from the National Family Health Survey-4 conducted in 2015–16. A two-stage least squares (2SLS) regression model was used to account for the issue of endogeneity that appears in a general logit model. The use of contraceptives by the sample women was found to be associated with greater women’s empowerment in terms of both their mobility and decision-making power. The pathways to greater women’s empowerment are often presumed to be factors such as changing perception of their domestic role and sense of control over their own body. While these are integral, this paper highlights how the possible control over family size and birth interval through use of contraception may also be critical pathways to increasing women’s empowerment.
At the Crossroads of Empire and Nation-State: Partition, gold smuggling, and port cities in the western Indian Ocean
Authors: MATHEW NISHA
Published: October 2019

This article investigates gold smuggling in the twentieth-century western Indian Ocean. It illustrates how gold, condemned as a ‘barbarous relic’ by international monetary economists and central banks in the immediate post-war period, created an economy in the intermediate zone between a retreating empire and emerging nation-states in India and the Persian Gulf. Bombay and Dubai—connected by mercantile networks, trading dhows, migrants, and ‘smugglers’—were the principal constituencies and key drivers of this trans-regional economy. Partition and the concomitant flight of Indian mercantile capital into Dubai becomes the key to unlocking the many dimensions of smuggling, including its social organization and ethnic constitution. Looked at in such terms, gold smuggling reveals a transnational side to both partition and the post-colonial history of Bombay which has drawn little critical attention from historians. Consequently, it expands the analytic space necessary to explain how Dubai was able to capitalize on the arbitrage possibilities offered by import regulations in India, tap into the global networks of trade and finance, and chart its own course of development as a modern urban space throughout the latter half of the twentieth century.
The Haiphong Shipping Boycotts of 1907 and 1909–10: Business interactions in the Haiphong-Hong Kong rice shipping trade
Authors: BECKER BERT
Published: October 2019

The main focus of this article is the Haiphong shipping boycotts of 1907 and 1909–10, which were conflicts over freight rates on rice which arose between several Chinese rice hongs in Haiphong (Hải Phòng), the main port in northeastern French Indochina, and three European tramp shipping companies. When these companies set up a joint agreement in 1907 unilaterally increasing the freight rates for shipping rice to Hong Kong, the affected merchants felt unfairly treated and boycotted the companies’ ships. Furthermore, in 1909, they formed a rival charter syndicate and set up a steamship company chartering the vessels of other companies to apply additional pressure on the firms to return to the previous rate. Although the Chinese suffered direct financial losses due to their insufficient expertise in this business, they were successful in achieving a considerable decrease in the freight rate on rice, which shows that boycotting, even when costly, proved to be an effective means to push for reductions and better arrangements with shipping companies. In contrast to a similar incident in the same trade—the shipping boycott of 1895–96 when the French government intervened with the Chinese government on behalf of a French shipping company—the later boycotts did not provoke the intervention of Western powers. This case suggests that growing anti-imperialism and nationalism in China, expressed in public discourses on shipping rights recovery and in the use of economic instead of political means, had an impact on the boycotts. Economic, not imperial, power determined the outcome of this struggle.
Patterns of gender assignment in the Jamtlandic variety of Scandinavian
Authors: Van Epps Briana , Carling Gerd
Published: October 2019

In this study, we present an analysis of gender assignment tendencies in Jamtlandic, a language variety of Sweden, using a word list of 1029 items obtained from fieldwork. Most research on gender assignment in the Scandinavian languages focuses on the standard languages (Steinmetz 1985; Källström 1996; Trosterud 2001, 2006) and Norwegian dialects (Enger 2011, Kvinlaug 2011, Enger & Corbett 2012). However, gender assignment principles for Swedish dialects have not previously been researched. We find generalizations based on semantic, morphological, and phonological principles. Some of the principles apply more consistently than others, some ‘win’ in competition with other principles; a multinomial logistic regression analysis provides a statistical foundation for evaluating the principles. The strongest tendencies are those based on biological sex, plural inflection, derivational suffixes, and some phonological sequences. Weaker tendencies include non-core semantic tendencies and other phonological sequences. Gender assignment in modern loanwords differs from the overall material, with a larger proportion of nouns assigned masculine gender.
On sets of points with few odd secants
Authors: Ball Simeon , Csajbók Bence
Published: October 2019

We prove that, for q odd, a set of q + 2 points in the projective plane over the field with q elements has at least 2q − c odd secants, where c is a constant and an odd secant is a line incident with an odd number of points of the set.
How do grammatical patterns emerge? The origins and development of the English proper noun modifier construction
Authors: BREBAN TINE , DE SMET HENDRIK
Published: October 2019

This article studies the emergence of a grammatical pattern, the proper noun modifier construction shown inthe Obama administration,an Edinburgh restaurant. The only dedicated historical corpus study, by Rosenbach (2007, 2010), is limited in terms of time depth and data included, and suggests that only proper noun modifiers denoting places such asEdinburghare found in the early seventeenth century. Using corpus data that span the full history of English, we trace the construction back to two Old English precursors, genitival modifiers without inflectional marking, e.g.Jericho feldes‘the fields of Jericho’, and compounds, e.g.Easter æfen‘Easter eve’. We combine macro-level visualisations of distributions and qualitative micro-analyses to show how these source constructions developed into the present-day English construction. The development defies simplistic views on grammatical change, but illustrates that grammatical patterns develop out of multiple sources under the influence of a multiplicity of factors. New patterns only emerge gradually and exploit existing ambiguities in the language.
The impact of semantic relations on grammatical alternation: an experimental study of proper name modifiers and determiner genitives
Authors: BREBAN TINE , KOLKMANN JULIA , PAYNE JOHN
Published: October 2019

In this article we investigate the role of semantic relations in grammatical alternations. The specific alternation we look at is that between the proper name modifier construction, e.g.the Obama government, and the determiner genitive, e.g.Obama's government. Through the use of an experimental study in which participants were asked to rate the naturalness of the two constructions in 20 attested natural language contexts and provide paraphrases of the semantic relations in question, we tested when the two constructions alternate and whether either construction expresses semantic relations that block alternation. Our initial finding is that none of the relations we studied is categorically associated with only one of the constructions, but that certain relations – notably possession and name – are far more preferentially associated with determiner genitives and proper name modifiers respectively. Despite these ‘default’ associations, participants nevertheless identified a range of possible interpretations for many of the examples, meaning that our study simultaneously supports the opposing theoretical views of default relations and semantic underspecification. Further, our study validates the inclusion of semantic relations in genitive alternation studies as a major factor despite the notorious difficulties in their operationalisation. Animacy distinctions, although more straightforward to codify, appear to be of lesser importance. Methodologically, our study shows the value of an experimental approach as a corrective to researcher intuitions about the identification of semantic relations in context.
A roadmap for heritage language research
Authors: Polinsky Maria , Scontras Gregory
Published: October 2019

Our keynote, “Understanding heritage languages” (Polinsky & Scontras, 2019), and the commentaries to it make the following main points.
Eddies in the Tropical Atlantic Ocean and Their Seasonal Variability
Authors: Aguedjou H. M. A. , Dadou I. , Chaigneau A. , Morel Y. , Alory G.
Published: October 2019

We study mesoscale eddy characteristics in the tropical Atlantic Ocean, using 23 years of daily altimetry sea level anomalies. Eddies are mainly generated in the eastern boundary upwelling systems and in the Brazil Current region. Their westward propagation speed reaches 20 cm/s in equatorial areas, decreasing with latitudes. They present typical amplitudes of 1‐5 cm. The largest and most energetic eddies are observed in the equatorial region, especially in the North Brazil Current (NBC) retroflection. The seasonal cycle of the eddy characteristics shows higher amplitudes along the NBC retroflection and the western part of the North Equatorial Countercurrent. A new criterion, based on altimetry data, determines the probability that barotropic instability of mean surface currents is responsible for eddy generation. We find a strong likelihood that the latter plays a key role along the North Equatorial Countercurrent, whereas other mechanisms must be invoked for the NBC region.
Numerical Analysis of Time‐Dependent Conduit Magma Flow in Dome‐Forming Eruptions With Application to Mount St. Helens 2004–2008
Authors: Wong Ying‐Qi , Segall Paul
Published: October 2019

Conduit models of volcanic eruptions simulate magma evolution through phase transitions and material changes during ascent. We present a time‐dependent one‐dimensional model of a chamber‐conduit system to examine the temporal evolution of dome‐forming eruptions. As magma ascends, volatiles exsolve and may escape vertically through the column or laterally through the conduit walls. Magma solidifies which increases viscosity, leading to a natural transition from viscous flow at depth to frictional sliding along the conduit walls near the surface, resulting in the extrusion of a semisolid plug. The model evaluates time‐ and depth‐dependent pressure, velocity, porosity, and relative amounts of exsolved water to carbon dioxide. Transient effects arise when magma outflux from the chamber appreciably decreases pressure over the magma ascent timescale. For low magma permeability, transient effects increase porosity and velocity relative to steady‐state solutions. For high magma permeability, efficient vertical and lateral gas escape depresses porosity and velocity at later times. We use the model to predict three time series data sets from the 2004–2008 eruption of Mount St. Helens: extruded volume, ground deformation, and carbon dioxide emissions. We quantify sensitivity of model predictions to input parameters using the distance‐based generalized sensitivity analysis. Chamber volatile content, volume, and excess pressure influence the amplitude of observables, while conduit radius, frictional rate dependence and magma permeability influence temporal evolution. High magma permeability can cause marked departures from exponentially decaying flux and may explain the unique temporal evolution of deformation observed at the only nearby continuous GPS station in operation at the eruption onset.
SAMEERDU—Digital Ionosonde: Brief System Description and Initial Results from a Low‐Latitude Location Dibrugarh
Authors: Kalita B.R. , Nath Sankar J. , Bhuyan P.K. , Khandare Ajay , Kulkarni Anil
Published: October 2019

A digital ionosonde was designed and built by Society for Applied Microwave Electronics Engineering and Research (SAMEER), Mumbai in collaboration with Dibrugarh University to suit the needs of equatorial‐ and low‐latitude regions of India. The design objectives were to obtain good signal‐to‐noise ratio to mitigate the heavy noise due to interference, obtain short duration ionograms, estimate vertical drifts, reconstruct vertical electron density profile, and make antenna size smaller. Transmission of maximum 1 kW power using modified delta antenna is used with dual channel magnetic loop receiver antenna. Pulse compression by 8‐ and 16‐bit biphase codes are employed to increase noise immunity and the height resolution. The preliminary results of the ionogram mode only are presented in this work. The basic ionogram recorded by this system called SAMEER‐Dibrugarh University Ionospheric Radar is compared with colocated Canadian Advanced Digital Ionosonde ionogram which is in operation in Dibrugarh since 2010. A reasonably clear trace of E and F layers is obtained even without coherent pulse integration and pulse coding. The performance of the coding schemes is investigated with and without coherent integration. Some sample ionospheric experiments conducted with SAMEER‐Dibrugarh University Ionospheric Radar, and interesting results like the detection of travelling ionospheric disturbances, Es layer substructures, ionospheric irregularities, and the generation of bottom‐side vertical electron density profile are presented to highlight the potential and capabilities of the system.
Using Physically Based Synthetic Peak Flows to Assess Local and Regional Flood Frequency Analysis Methods
Authors: Perez Gabriel , Mantilla Ricardo , Krajewski Witold F. , Wright Daniel B.
Published: October 2019

Although prior studies have evaluated the role of sampling errors associated with local and regional methods to estimate peak flow quantiles, the investigation of epistemic errors is more difficult because the underlying properties of the random variable have been prescribed using ad‐hoc characterizations of the regional distributions of peak flows. This study addresses this challenge using representations of regional peak flow distributions derived from a combined framework of stochastic storm transposition, radar rainfall observations, and distributed hydrologic modeling. The authors evaluated four commonly used peak flow quantile estimation methods using synthetic peak flows at 5,000 sites in the Turkey River watershed in Iowa, USA. They first used at‐site flood frequency analysis using the Pearson Type III distribution with L‐moments. The authors then pooled regional information using (1) the index flood method, (2) the quantile regression technique, and (3) the parameter regression. This approach allowed quantification of error components stemming from epistemic assumptions, parameter estimation method, sample size, and, in the regional approaches, the number of pooled sites. The results demonstrate that the inability to capture the spatial variability of the skewness of the peak flows dominates epistemic error for regional methods. We concluded that, in the study basin, this variability could be partially explained by river network structure and the predominant orientation of the watershed. The general approach used in this study is promising in that it brings new tools and sources of data to the study of the old hydrologic problem of flood frequency analysis.
Pore‐Scale Investigation of Methane Hydrate Dissociation Using the Lattice Boltzmann Method
Authors: Zhang Liming , Zhang Chuangde , Zhang Kai , Zhang Lei , Yao Jun , Sun Hai , Yang Yongfei
Published: October 2019

Fundamental understanding of pore‐scale methane hydrate dissociation in porous media is important to evaluate submarine slope stability and potential utilization of methane resources. In this paper, a general pore‐scale framework based on the lattice Boltzmann (LB) method is established for reactive transport coupled with nonisothermal multiple physicochemical processes in porous media. The framework combines the gas hydrate dissociation kinetic model, the single‐phase flow LB model, the mass transport LB model, and the conjugate heat transfer LB model. The pore‐scale framework is validated by several benchmark problems and then employed to investigate the endothermic dissociation process of methane hydrate with pore‐filling and grain‐coating habits in porous media. The methane hydrate endothermic dissociation behavior coupled with nonlinear nonisothermal multiple physicochemical processes involving intrinsic dissociation dynamics, gas flow, mass transport, phase change heat transfer, and conjugate heat transfer is well captured by the framework. The phase change of methane hydrate dissociation and pore structure evolution for different pore habits of hydrate are well depicted, and some insights about the dissociation front advancement and temperature distributions are also obtained. In addition, the effects of temperature field, inlet temperature, and inlet pressure on methane hydrate dissociation are investigated. The pore‐scale methane hydrate dissociation helps to advance our understanding of permeability‐saturation variation relation for continuum models.
poFUT1 promotes uterine angiogenesis and vascular remodeling via enhancing the O-fucosylation on uPA
Authors: Zhang Dandan , Yang Yu , Liang Caixia , Liu Jianwei , Wang Hao , Liu Shuai , Yan Qiu
Published: October 2019

Uterine angiogenesis and vascular remodeling play critical roles in determing the normal menstrual cycle and successful pregnancy. Poor uterine angiogenesis usually results in pregnancy failure. Protein O-fucosyltransferase 1 (poFUT1) is the key enzyme responsible for O-fucosylated glycan biosynthesis on glycoproteins. However, the dynamic expression and regulation of poFUT1 on the uterine angiogenesis and vascular remodeling remain unknown. Here, we showed that the enlargement of the vascular lumen in the secretory phase was greater than that in the proliferative phase of the uterine endometrium during menstrual cycle; whereas there was a narrower vessel lumen and fewer blood vessels in the decidua from miscarriage patients than in that from healthy pregnancy women. Additionally, the expression of poFUT1 was increased in the uterine endometrium during the secretory phase compared with that in the proliferation phase, and its expression was decreased in the uterus of miscarriage patients compared with that of the healthy pregnancy women. Using hESCs and a mouse model, we demonstrated that poFUT1 increased the O-fucosylation on uPA, and activated of the RhoA signaling pathway, thus facilitating uterine angiogenesis and vascular remodeling. We also provide evidence that poFUT1 promotes hESCs angiogenesis by the decreased stemness of hESCs. These findings reveal a new insight into the uterine angiogenesis and vascular remodeling. The study suggests that poFUT1 could be seen as a novel potential diagnostic and therapeutic target for miscarriage.
Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways
Authors: Zhang Xi , Hou Guoqing , Liu Andong , Xu Hui , Guan Yang , Wu Yaosong , Deng Jie , Cao Xuan
Published: October 2019

Ovarian cancer remains the most lethal gynecologic malignancy with late detection and acquired chemoresistance. Advanced understanding of the pathophysiology and novel treatment strategies are urgently required. A growing body of proteomic investigations suggest that phosphorylation has a pivotal role in the regulation of ovarian cancer associated signaling pathways. Matrine has been extensively studied for its potent anti-tumor activities. However, its effect on ovarian cancer cells and underlying molecular mechanisms remain unclear. Herein we showed that matrine treatment inhibited the development and progression of ovarian cancer cells by regulating proliferation, apoptosis, autophagy, invasion and angiogenesis. Matrine treatment retarded the cancer associated signaling transduction by decreasing the phosphorylation levels of ERK1/2, MEK1/2, PI3K, Akt, mTOR, FAK, RhoA, VEGFR2, and Tie2 in vitro and in vivo. Moreover, matrine showed excellent antitumor effect on chemoresistant ovarian cancer cells. No obvious toxic side effects were observed in matrine-administrated mice. As the natural agent, matrine has the potential to be the targeting drug against ovarian cancer cells with the advantages of overcoming the chemotherapy resistance and decreasing the toxic side effects.
Asymmetric distribution of cytokinins determines root hydrotropism in Arabidopsis thaliana
Authors: Chang Jinke , Li Xiaopeng , Fu Weihao , Wang Jiawen , Yong Yueyuan , Shi Hongyong , Ding Zhaojun , Kui Hong , Gou Xiaoping , He Kai , Li Jia
Published: October 2019

The phenomenon of plant root tips sensing moisture gradient in soil and growing towards higher water potential is designated as root hydrotropism, which is critical for plants to survive when water is a limited factor. Molecular mechanisms regulating such a fundamental process, however, are largely unknown. Here we report our identification that cytokinins are key signaling molecules directing root growth orientation in a hydrostimulation (moisture gradient) condition. Lower water potential side of the root tip shows more cytokinin response relative to the higher water potential side. Consequently, two cytokinin downstream type-A response regulators, ARR16 and ARR17, were found to be up-regulated at the lower water potential side, causing increased cell division in the meristem zone, which allows the root to bend towards higher water potential side. Genetic analyses indicated that various cytokinin biosynthesis and signaling mutants, including the arr16 arr17 double mutant, are significantly less responsive to hydrostimulation. Consistently, treatments with chemical inhibitors interfering with either cytokinin biosynthesis or cell division completely abolished root hydrotropic response. Asymmetrically induced expression of ARR16 or ARR17 effectively led to root bending in both wild-type and miz1, a previously known hydrotropism-defective mutant. These data demonstrate that asymmetric cytokinin distribution is a primary determinant governing root hydrotropism.
Entrainment of local synchrony reveals a causal role for high-beta right frontal oscillations in human visual consciousness
Authors: Vernet Marine , Stengel Chloé , Quentin Romain , Amengual Julià L. , Valero-Cabré Antoni
Published: October 2019

Prior evidence supports a critical role of oscillatory activity in visual cognition, but are cerebral oscillations simply correlated or causally linked to our ability to consciously acknowledge the presence of a target in our visual field? Here, EEG signals were recorded on humans performing a visual detection task, while they received brief patterns of rhythmic or random transcranial magnetic stimulation (TMS) delivered to the right Frontal Eye Field (FEF) prior to the onset of a lateralized target. TMS entrained oscillations, i.e., increased high-beta power and phase alignment (the latter to a higher extent for rhythmic high-beta patterns than random patterns) while also boosting visual detection sensitivity. Considering post-hoc only those participants in which rhythmic stimulation enhanced visual detection, the magnitude of high-beta entrainment correlated with left visual performance increases. Our study provides evidence in favor of a causal link between high-beta oscillatory activity in the Frontal Eye Field and visual detection. Furthermore, it supports future applications of brain stimulation to manipulate local synchrony and improve or restore impaired visual behaviors.
Role of biomarkers as predictors of acute kidney injury and mortality in decompensated cirrhosis
Authors: Jo Sang Kyung , Yang Jihyun , Hwang Sang Muk , Lee Myung Seok , Park Sang Hoon
Published: October 2019

Evidence suggests that novel biomarkers predict acute kidney injury (AKI) development and outcome earlier than serum creatinine. The aim of this study was to determine the incidence and prognosis of AKI in decompensated cirrhotic patients, and also assess the usefulness of plasma cystatin C, urine neutrophil gelatinase associated lipocalin (NGAL), tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) in early prediction of AKI and mortality. Single-center, prospective observational study enrolling decompensated cirrhotic patients without AKI at the time of admission. Of 111 patients with decompensated cirrhosis, 45 (40.5%) developed AKI while hospitalized. Even with 53.3% being transient (stage 1), mortality was significantly higher in AKI than non-AKI patients (46.5% vs. 25%, p = 0.02). Plasma cystatin C and urine NGAL, but not urine [TIMP-2]·[IGFBP7] at the time of admission were found to be independent early predictors of AKI. Substitution of cystatin C for creatinine significantly improved the model for end-stage liver disease (MELD) score accuracy for mortality prediction. The incidence of AKI is high and is associated with high mortality in decompensated cirrhotic patients. Plasma cystatin C and urine NGAL are useful for early detection of AKI. MELD-cystatin C, rather than original MELD, improves predictive accuracy of mortality.
Evaluation of sxtA and rDNA qPCR assays through monitoring of an inshore bloom of Alexandrium catenella Group 1
Authors: Murray Shauna A. , Ruvindy Rendy , Kohli Gurjeet S. , Anderson Donald M. , Brosnahan Michael L.
Published: October 2019

Alexandrium catenella (formerly A. tamarense Group 1, or A. fundyense) is the leading cause of Paralytic Shellfish Poisoning in North and South America, Europe, Africa, Australia and Asia. The quantification of A.catenella via sxtA, a gene involved in Paralytic Shellfish Toxin synthesis, may be a promising approach, but has not been evaluated in situ on blooms of A. catenella, in which cell abundances may vary from not detectable to in the order of 106 cells L−1. In this study, we compared sxtA assay performance to a qPCR assay targeted to a species-specific region of ribosomal DNA (rDNA) and an established fluorescent in situ hybridization (FISH) microscopy method. Passing-Bablok regression analyses revealed the sxtA assay to overestimate abundances when <5 cell equivalents A. catenella DNA were analysed, but otherwise was closer to microscopy estimates than the rDNA assay, which overestimated abundance across the full range of concentrations analysed, indicative of a copy number difference between the bloom population and a culture used for assay calibration a priori. In contrast, the sxtA assay performed more consistently, indicating less copy number variation. The sxtA assay was generally reliable, fast and effective in quantifying A. catenella and was predictive of PST contamination of shellfish.
Concentrates of two subsets of extracellular vesicles from cow’s milk modulate symptoms and inflammation in experimental colitis
Authors: Benmoussa Abderrahim , Diallo Idrissa , Salem Mabrouka , Michel Sara , Gilbert Caroline , Sévigny Jean , Provost Patrick
Published: October 2019

Extracellular vesicles (EVs) are involved in cell-to-cell communication and modulation of numerous physiological and pathological processes. EVs are found in large quantities in milk and contain several inflammation- and immunity-modulating proteins and microRNAs, through which they exert beneficial effects in several inflammatory disease models. Here, we investigated the effects of two EV subsets, concentrated from commercial cow’s milk, on a murine model of colitis induced with dextran sodium sulfate (DSS). P35K EVs, isolated by ultracentrifugation at 35,000 g, and P100K EVs, isolated at 100,000 g, were previously characterized and administered by gavage to healthy and DSS-treated mice. P35K EVs and, to a lesser extent, P100K EVs improved several outcomes associated to DSS-induced colitis, modulated the gut microbiota, restored intestinal impermeability and replenished mucin secretion. Also, P35K EVs modulated innate immunity, while P100K EVs decreased inflammation through the downregulation of colitis-associated microRNAs, especially miR-125b, associated with a higher expression of the NFκB inhibitor TNFAIP3 (A20). These results suggest that different milk EV subsets may improve colitis outcomes through different, and possibly complementary, mechanisms. Further unveiling of these mechanisms might offer new opportunities for improving the life of patients with colitis and be of importance for milk processing, infant milk formulation and general public health.