bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Progress and Challenges of Electron Transport Layers in Organic–Inorganic Perovskite Solar Cells
Authors: Kim Taewan , Lim Jongchul , Song Seulki
Published: October 2020

Organic–inorganic perovskites are crystalline light absorbers which are gaining great attraction from the photovoltaic community. Surprisingly, the power conversion efficiencies of these perovskite solar cells have rapidly increased by over 25% in 2019, which is comparable to silicon solar cells. Despite the many advances in efficiency, there are still many areas to be improved to increase the efficiency and stability of commercialization. For commercialization and enhancement of applicability, the development of electron transport layer (ETL) and its interface for low temperature processes and efficient charge transfer are very important. In particular, understanding the ETL and its interface is of utmost importance, and when this understanding has been made enough, excellent research results have been published that can improve the efficiency and stability of the device. Here, we review the progress of perovskite solar cells. Especially we discuss recent important development of perovskite deposition method and its engineering as well as the electron transport layer.
SiC-Based Power Electronic Traction Transformer (PETT) for 3 kV DC Rail Traction
Authors: Adamowicz Marek , Szewczyk Janusz
Published: October 2020

The design of rolling stock plays a key role in the attractiveness of the rail transport. Train design must strictly meet the requirements of rail operators to ensure high quality and cost-effective services. Semiconductor power devices made from silicon carbide (SiC) have reached a level of technology enabling their widespread use in traction power converters. SiC transistors offering energy savings, quieter operation, improved reliability and reduced maintenance costs have become the choice for the next-generation railway power converters and are quickly replacing the IGBT technology which has been used for decades. The paper describes the design and development of a novel SiC-based DC power electronic traction transformer (PETT) intended for electric multiple units (EMUs) operated in 3 kV DC rail traction. The details related to the 0.5 MVA peak power medium voltage prototype, including the electrical design of the main building blocks are presented in the first part of the paper. The second part deals with the implementation of the developed SiC-based DC PETT into a regional train operating on a 3 kV DC traction system. The experimental results obtained during the testing are presented to demonstrate the performance of the developed 3 kV DC PETT prototype.
Heat Generated Using Luminescent Solar Concentrators for Building Energy Applications
Authors: Daigle Quinn , O’Brien Paul G.
Published: October 2020

Luminescent solar concentrators (LSCs) are a promising technology for integration and renewable energy generation in buildings because they are inexpensive, lightweight, aesthetically versatile, can concentrate both direct and diffuse light and offer wavelength-selective transparency. LSCs have been extensively investigated for applications involving photovoltaic electricity generation. However, little work has been done to investigate the use of thermal energy generated at the edges of LSCs, despite the potential for harnessing a broad range of solar thermal energy. In this work, Newton’s law of cooling is used to measure the thermal power generated at the edge of LSC modules subjected to solar-simulated radiation. Results show that the dye in single-panel LSC modules can generate 17.9 W/m2 under solar-simulated radiation with an intensity of 23.95 mW/cm2 over the spectral region from 360 to 1000 nm. Assuming a mean daily insolation of 5 kWh/m2, the dye in the single-panel LSC modules can generate ~100 kWh/m2 annually. If the surface area of a building is comparable to its floor space, thermal energy generated from LSCs on the buildings surface could be used to substantially reduce the buildings energy consumption.
Active Shielding Design and Optimization of a Wireless Power Transfer (WPT) System for Automotive
Authors: Cruciani Silvano , Campi Tommaso , Maradei Francesca , Feliziani Mauro
Published: October 2020

This study deals with the optimization of a shielding structure composed by multiple active coils for mitigating the magnetic field in an automotive wireless power transfer (WPT) system at 85 kHz. Each active coil is independently powered and the most suitable excitation is obtained by an optimization procedure based on the Gradient Descent algorithm. The proposed procedure is described and applied to shield the magnetic field beside an electric vehicle (EV) equipped with SAE standard coils, during wireless charging. The obtained results show that the magnetic field in the most critical area is significantly reduced (i.e., approximately halved) with a very limited influence on the electrical performances (i.e., WPT efficiency decreases by less than 1 percentage point compared to the case without active shielding).
Wave-to-Wire Model of an Oscillating-Water-Column Wave Energy Converter and Its Application to Mediterranean Energy Hot-Spots
Authors: Ciappi Lorenzo , Cheli Lapo , Simonetti Irene , Bianchini Alessandro , Manfrida Giampaolo , Cappietti Lorenzo
Published: October 2020

Oscillating water column (OWC) systems are among the most credited solutions for an effective conversion of the notable energy potential conveyed by sea waves. Despite a renewed interest, however, they are often still at a demonstration phase and additional research is required to reach industrial maturity. Within this framework, this study provides a wave-to-wire model for OWC systems based on an impulse air turbine. The model performs a comprehensive simulation of the system to estimate the attendant electric energy production for a specific sea state, based on analytical models of the primary (fixed chamber) and secondary (air turbine) converters coupled with the tertiary converter (electric generator). A rigid piston model is proposed to solve the hydrodynamics, thermodynamics, and hydrodynamics of the chamber, in a coupled fashion with the impulse turbine aerodynamics. This is solved with a novel method by considering the cascades as sets of blades, each one consisting of a finite number of airfoils stacked in the radial direction. The model was applied for two Mediterranean sites located in Tuscany and Sardinia (Italy), which were selected to define the optimal geometry of the turbine for a specified chamber. For each system, the developed analytical wave-to-wire model was applied to calculate the performance parameters and the annual energy production in environmental conditions typical of the Mediterranean Sea. The selected impulse turbines are able to convert 13.69 and 39.36 MWh/year, with an efficiency of 4.95% and 4.76%, respectively, thus proving the interesting prospects of the technology.
Hydrogeochemistry and Related Processes Controlling the Formation of the Chemical Composition of Thermal Water in Podhale Trough, Poland
Authors: Sekuła Klaudia , Rusiniak Piotr , Wątor Katarzyna , Kmiecik Ewa
Published: October 2020

The most promising Polish region in terms of its geothermal resource potential is the Podhale Trough in the Inner West Carpathians, where the thermal water occurs in the Eocene-Mesozoic strata. The origin and conditions of formation of the chemical composition of the thermal water are different in a regional scale due to the impact of infiltrating water on the chemical compounds present in nearby thermal intakes, chemical processes responsible for the concentration of major elements and residence time. The article presents the regional conceptual model in regard to the factors controlling the chemistry of thermal water from Podhale Trough and the conditions of its exchange. It was allowed by performing the hydrogeochemical characteristics of studied water and analyzing its changes according to flow direction from HCO3-Ca-Mg type to SO4-Cl-Na-Ca and SO4-Ca-Mg types. The hydrogeochemical modelling was also made allowing identification of the impact of reservoir rocks on the formation of the chemical composition. For confirmation of the theories formulated and for more accurate interpretation of the results obtained from hydrogeochemical modelling, hydrochemical indices were calculated, i.e., rHCO3−/rCl−, rNa+/rCl−, rCa2+/rMg2+, rCa2+/(rCa2+ + rSO42−) and rNa+/(rNa+ + rCl−). The results revealed the most important processes evolving the chemistry of thermal water are progressive freshening of the thermal water reservoir, which in the past was filled with salty water, dissolution of gypsum, and ongoing dolomitization. Conducted research presents the important factors that in the case of increased exploitation of thermal water in the Podhale Trough, may influence the quality of thermal water in terms of its physical and chemical parameters.
A Systematic Literature Review of Reverse Logistics of End-of-Life Vehicles: Bibliometric Analysis and Research Trend
Authors: He Meiling , Lin Tianhe , Wu Xiaohui , Luo Jianqiang , Peng Yongtao
Published: October 2020

Under the background of the prompt development of the global economy and continuous improvement of environmental protection awareness, end-of-life vehicles (ELVs), as an essential part of “urban mineral”, have the substantial economic, resource, and environmental value. The research on reverse logistics of ELVs has developed rapidly, but the existing relevant reviews are based on unique research perspectives and do not fully understand the whole field. This work aims to help comprehend the research status of reverse logistics of ELVs, excavate and understand the critical publications, and reveal the main research topics in the past 20 years. Based on 299 articles published in ISI Web of Science Core Collection (WOSCC) database from 2000 to 2019, this paper uses the methodologies of literature bibliometrics and content analysis, combined with VOS viewer, CiteSpace, and Bibexcel software. Besides, the literature quantity and cited situation, core journals, distribution of countries and regions, institutions, core authors, subject categories, and keywords information are analyzed to determine the primary trends and future research hot spots focus on reverse logistics of ELVs.
The Financing of Renewable Energy Sources and the Level of Sustainable Development of Poland’s Provinces in the Area of Environmental Order
Authors: Siemiątkowski Piotr , Tomaszewski Patryk , Marszałek-Kawa Joanna , Gierszewski Janusz
Published: October 2020

The overall purpose of this study is to evaluate the impact of financing renewable energy sources on the assessment of sustainable development in Poland’s provinces. There are also two detailed objectives: (1) define how Polish policies are being passed on to local authorities; (2) realize a Poland’s provinces ranking, taking into account the indicators of sustainable development, thanks to the taxonomic measure of development in the area of environmental order. This study deals with the taxonomic assessment of local sustainable development in the local administration units of Poland. To this end, the methods of linear ordering were applied for the assessment of the level of objects differentiation with the use of a closed set of statistical features. The presented analysis proved that the taxonomic distances between synthetic measures for particular provinces are considerable. The highest values of the integrated measure in 2018 were obtained by the following provinces: Podlaskie, Subcarpathian and Lubusz. It is noteworthy to point to the big changes in the ranking between 2018 and 2016. The cluster analysis showed some progress in achieving the goals of sustainable development. The group of provinces with an average level of sustainable development in 2018 included six provinces compared to two provinces in 2016. Removing one indicator from the integrated measure (the financing of renewable energy sources (RES)) led to a moderate increase in the integrated measure across all the provinces. This implies that, on average, the financing of renewable energy sources exerts increasingly smaller impacts on the level of sustainable development in Poland.
Optimization of a 660 MWe Supercritical Power Plant Performance—A Case of Industry 4.0 in the Data-Driven Operational Management Part 1. Thermal Efficiency
Authors: Muhammad Ashraf Waqar , Moeen Uddin Ghulam , Muhammad Arafat Syed , Afghan Sher , Hassan Kamal Ahmad , Asim Muhammad , Haider Khan Muhammad , Waqas Rafique Muhammad , Naumann Uwe , Niazi Sajawal Gul , Jamil Hanan , Jamil Ahsaan , Hayat Nasir , Ahmad Ashfaq , Changkai Shao , Bin Xiang Liu , Ahmad Chaudhary Ijaz , Krzywanski Jaroslaw
Published: October 2020

This paper presents a comprehensive step-wise methodology for implementing industry 4.0 in a functional coal power plant. The overall efficiency of a 660 MWe supercritical coal-fired plant using real operational data is considered in the study. Conventional and advanced AI-based techniques are used to present comprehensive data visualization. Monte-Carlo experimentation on artificial neural network (ANN) and least square support vector machine (LSSVM) process models and interval adjoint significance analysis (IASA) are performed to eliminate insignificant control variables. Effective and validated ANN and LSSVM process models are developed and comprehensively compared. The ANN process model proved to be significantly more effective; especially, in terms of the capacity to be deployed as a robust and reliable AI model for industrial data analysis and decision making. A detailed investigation of efficient power generation is presented under 50%, 75%, and 100% power plant unit load. Up to 7.20%, 6.85%, and 8.60% savings in heat input values are identified at 50%, 75%, and 100% unit load, respectively, without compromising the power plant’s overall thermal efficiency.
In Situ Wettability Investigation of Aging of Sandstone Surface in Alkane via X-ray Microtomography
Authors: Jha Nilesh Kumar , Lebedev Maxim , Iglauer Stefan , Sangwai Jitendra S. , Sarmadivaleh Mohammad
Published: October 2020

Wettability of surfaces remains of paramount importance for understanding various natural and artificial colloidal and interfacial phenomena at various length and time scales. One of the problems discussed in this work is the wettability alteration of a three-phase system comprising high salinity brine as the aqueous phase, Doddington sandstone as porous rock, and decane as the nonaqueous phase liquid. The study utilizes the technique of in situ contact angle measurements of the several 2D projections of the identified 3D oil phase droplets from the 3D images of the saturated sandstone miniature core plugs obtained by X-ray microcomputed tomography (micro-CT). Earlier works that utilize in situ contact angles measurements were carried out for a single plane. The saturated rock samples were scanned at initial saturation conditions and after aging for 21 days. This study at ambient conditions reveals that it is possible to change the initially intermediate water-wet conditions of the sandstone rock surface to a weakly water wetting state on aging by alkanes using induced polarization at the interface. The study adds to the understanding of initial wettability conditions as well as the oil migration process of the paraffinic oil-bearing sandstone reservoirs. Further, it complements the knowledge of the wettability alteration of the rock surface due to chemisorption, usually done by nonrepresentative technique of silanization of rock surface in experimental investigations.
Stump Sprout Characteristics of Three Commercial Tree Species in Suriname
Authors: Ramdial Donna , Sewdien Artie , Rasdan Jerry , Critchlow Shermaine , Tjong-A-Hung Noraisah , Ospina Alejandra , Wortel Verginia , Putz Francis E
Published: October 2020

We compared stump sprouting by three common timber species in Suriname on the basis of sprout origins on stumps, sprout densities, and sprout height:diameter ratios. We then compared some leaf and stem functional traits of 15–18-month-old resprouts and nearby conspecific saplings of the same height (0.5–3.5 m) but unknown age. Stumps of Dicorynia guianensis Amsh. (29–103 cm in diameter) produced the most sprouts (x = 9.2/stump), followed by the 50–71 cm diameter stumps of Eperua falcata Amsh. (10.6/stump), and the 30–78 cm diameter Qualea rosea Amsh. (5.9/stump); sprout density did not vary with stump diameter. Sprouts emerged from the lower, middle, and upper thirds of the stumps of all three species, but not from the vicinity of the exposed vascular cambium in Qualea. With increased resprout density, heights of the tallest sprout per stump tended to increase but height:diameter ratios increased only in Dicorynia. Compared to conspecific saplings, sprouts displayed higher height-diameter ratios, higher leaf-to-wood mass ratios (LWR), and lower wood densities, but did not differ in leaf mass per unit area (LMA) or leaf water contents. These acquisitive functional traits may reflect increased resprout access to water and nutrients via the extensive root system of the stump. That we did not encounter live stump sprouts from the previous round of selective logging, approximately 25 years before our study, suggests that stump sprouts in our study area grow rapidly but do not live long.
Ensemble Classifiers for Network Intrusion Detection Using a Novel Network Attack Dataset
Authors: Mahfouz Ahmed , Abuhussein Abdullah , Venugopal Deepak , Shiva Sajjan
Published: October 2020

Due to the extensive use of computer networks, new risks have arisen, and improving the speed and accuracy of security mechanisms has become a critical need. Although new security tools have been developed, the fast growth of malicious activities continues to be a pressing issue that creates severe threats to network security. Classical security tools such as firewalls are used as a first-line defense against security problems. However, firewalls do not entirely or perfectly eliminate intrusions. Thus, network administrators rely heavily on intrusion detection systems (IDSs) to detect such network intrusion activities. Machine learning (ML) is a practical approach to intrusion detection that, based on data, learns how to differentiate between abnormal and regular traffic. This paper provides a comprehensive analysis of some existing ML classifiers for identifying intrusions in network traffic. It also produces a new reliable dataset called GTCS (Game Theory and Cyber Security) that matches real-world criteria and can be used to assess the performance of the ML classifiers in a detailed experimental evaluation. Finally, the paper proposes an ensemble and adaptive classifier model composed of multiple classifiers with different learning paradigms to address the issue of the accuracy and false alarm rate in IDSs. Our classifiers show high precision and recall rates and use a comprehensive set of features compared to previous work.
Electronic Nose for Monitoring Odor Changes of Lactobacillus Species during Milk Fermentation and Rapid Selection of Probiotic Candidates
Authors: Kovacs Zoltan , Bodor Zsanett , Zinia Zaukuu John-Lewis , Kaszab Timea , Bazar George , Tóth Tamás , Mohácsi-Farkas Csilla
Published: October 2020

Probiotic bacteria have been associated with a unique production of aroma compounds in fermented foods but rapid methods for discriminating between foods containing probiotic, moderately probiotic, or non-probiotic bacteria remain aloof. An electronic nose (e-nose) is a high-sensitivity instrument capable of non-invasive volatile measurements of foods. In our study, we applied the e-nose to differentiate probiotic, moderately probiotic, and non-probiotic Lactobacillus bacteria strains at different fermentation time points (0th, 4th, and 11th) of milk fermentation. The pH of the changing milk medium was monitored with their corresponding increase in microbial cell counts. An e-nose with two gas chromatographic columns was used to develop classification models for the different bacteria groups and time points and to monitor the formation of the aromatic compounds during the fermentation process. Results of the e-nose showed good classification accuracy of the different bacteria groups at the 0th (74.44% for column 1 and 82.78% for column 2), the 4th (89.44% for column 1 and 92.22% for column 2), and the 11th (81.67% for column 1 and 81.67% for column 2) hour of fermentation. The loading vectors of the classification models showed the importance of some specific aroma compounds formed during the fermentation. Results show that aroma monitoring of the fermentation process with the e-nose is a promising and reliable analytical method for the rapid classification of bacteria strains according to their probiotic activity and for the monitoring of aroma changes during the fermentation process.
Garlic: Much More Than a Common Spice
Authors: Netzel Michael E.
Published: October 2020

Garlic is a widely consumed and popular spice with a characteristic “aroma” or odour. It contains a broad range of bioactive components such as organosulfur compounds, saponins and polyphenols, but can be also rich in vitamins and minerals. Numerous biological properties are attributed to garlic, from antimicrobial activities to neuro- and renal-protection. In addition, post-harvest treatment, storage and processing, such as fermentation and heat, can have a significant effect on garlic and its bioactive compounds, and subsequently alter its bioactive properties. Future studies are warranted to elucidate the “full” biological potential of garlic including well designed human clinical trials, detailed storage and processing studies as well as sophisticated in vitro cell culture models to better understand the underlying mechanisms of action.
Effect of Hydration on Gluten-Free Breads Made with Hydroxypropyl Methylcellulose in Comparison with Psyllium and Xanthan Gum
Authors: Belorio Mayara , Gómez Manuel
Published: October 2020

The use of hydrocolloids in gluten-free breads is a strategy to improve their quality and obtain products with acceptable structural and textural properties. Hydration level (HL) optimization is important to maximize the hydrocolloids effects on dough and bread quality. This study evaluated the optimum hydration level (OHL) for gluten-free breads prepared with different starch sources (rice flour or maize starch) and hydroxypropyl methylcellulose (HPMC) in comparison with psyllium husk fibre and xanthan gum. Breads with the same final volume and the corrected hydration (CH) were evaluated. The hydration is a key factor that influences the final characteristics of gluten-free breads. Breads made with HPMC had greater dependence on the HL, especially for preparations with maize starch. Psyllium had similar behaviour to xanthan with respect to specific volume and weight loss. Breads manufactured with maize starch and HPMC had low hardness due to their great specific volume. However, in breads made with rice flour, the combined decreased hydration and similar specific volume generated a harder bread with HPMC than the use of psyllium or xanthan. Breads made with HPMC presented higher specific volume than the other hydrocolloids, however combinations among these hydrocolloids could be evaluated to improve gluten-free breads quality.
Dominance of S. cerevisiae Commercial Starter Strains during Greco di Tufo and Aglianico Wine Fermentations and Evaluation of Oenological Performances of Some Indigenous/Residential Strains
Authors: Aponte Maria , Romano Raffaele , Villano Clizia , Blaiotta Giuseppe
Published: October 2020

In order to evaluate dominance/implantation of starter cultures for wine fermentation, both commercial starters and wild strains were monitored during the fermentation of Greco di Tufo (GR) and Aglianico of Taurasi (AGL) musts. Preliminary characterization of commercial strains was carried out by several molecular markers. Five fermentations—four starter-inoculated and one spontaneous—were carried out in duplicates by using grapes from GR and AGL. Trials were monitored, and yeast cultures were isolated within the dominant microflora. Comparison of Interdelta patterns allowed to assess the real occurrence of both starters and indigenous strains. A high genetic diversity within S. cerevisiae strains was detected. In starter-led fermentations (except for few cases), in addition to the starter strains, indigenous S. cerevisiae biotypes were found, as well. Native strains isolated from replicates of the same fermentation showed different genetic profiles. Spontaneous fermentations were conducted, during the first 5 days, by non-Saccharomyces yeasts and, afterwards, by a high number (16 in the AGL and 20 in the GR) of S. cerevisiae biotypes. Indigenous biotypes isolated by GR revealed a high variability in oenological features and, in several cases, showed better performances than those recorded for commercial strains. The study further highlighted the low dominance of some commercial starter cultures. Moreover, autochthonous yeast strains proved to be sometimes more aggressive in terms of fermentation vigor in GR must, likely because better adapted to ecological and technological conditions occurring during winemaking. Finally, the use of such strains for production of autochthonous “pied de cuve” may be a useful strategy for lowering production cost of winemaking.
BARD1 and Breast Cancer: The Possibility of Creating Screening Tests and New Preventive and Therapeutic Pathways for Predisposed Women
Authors: Śniadecki Marcin , Brzeziński Michał , Darecka Katarzyna , Klasa-Mazurkiewicz Dagmara , Poniewierza Patryk , Krzeszowiec Marta , Kmieć Natalia , Wydra Dariusz
Published: October 2020

Current oncological developments are based on improved understanding of genetics, and especially the discovery of genes whose alterations affect cell functions with consequences for the whole body. Our work is focused on the one of these genes, BRCA1-associated RING domain protein 1 (BARD1), and its oncogenic role in breast cancer. Most importantly, the study points to new avenues in the treatment and prevention of the most frequent female cancer based on BARD1 research. The BARD1 and BRCA1 (BReast CAncer type 1) proteins have similar structures and functions, and they combine to form the new molecule BARD1-BRCA1 heterodimer. The BARD1-BRCA1 complex is involved in genetic stabilization at the cellular level. It allows to mark abnormal DNA fragments by attaching ubiquitin to them. In addition, it blocks (by ubiquitination of RNA polymerase II) the transcription of damaged DNA. Ubiquitination, as well as stabilizing chromatin, or regulating the number of centrosomes, confirms the protective cooperation of BARD1 and BRCA1 in the stabilization of the genome. The overexpression of the oncogenic isoforms BARD1β and BARD1δ permit cancer development. The introduction of routine tests, for instance, to identify the presence of the BARD1β isoform, would make it possible to detect patients at high risk of developing cancer. On the other hand, introducing BARD1δ isoform blocking therapy, which would reduce estrogen sensitivity, may be a new line of cancer therapy with potential to modulate responses to existing treatments. It is possible that the BARD 1 gene offers new hope for improving breast cancer therapy.
Transcriptome Analysis of Amyloodinium ocellatum Tomonts Revealed Basic Information on the Major Potential Virulence Factors
Authors: Byadgi Omkar , Marroni Fabio , Dirks Ron , Massimo Michela , Volpatti Donatella , Galeotti Marco , Beraldo Paola
Published: October 2020

The ectoparasite protozoan Amyloodinium ocellatum (AO) is the etiological agent of amyloodiniosis in European seabass (Dicentrarchus labrax) (ESB). There is a lack of information about basic molecular data on AO biology and its interaction with the host. Therefore, de novo transcriptome sequencing of AO tomonts was performed. AO trophonts were detached from infested ESB gills, and quickly becoming early tomonts were purified by Percoll® density gradient. Tomont total RNA was processed and quality was assessed immediately. cDNA libraries were constructed using TruSeq® Stranded mRNA kit and sequenced using Illumina sequencer. CLC assembly was used to generate the Transcriptome assembly of AO tomonts. Out of 48,188 contigs, 56.12% belong to dinophyceae wherein Symbiodinium microadriaticum had 94.61% similarity among dinophyceae. Functional annotations of contigs indicated that 12,677 had associated GO term, 9005 with KEGG term. The contigs belonging to dinophyceae resulted in the detection of several peptidases. A BLAST search for known virulent factors from the virulence database resulted in hits to Rab proteins, AP120, Ribosomal phosphoprotein, Heat-shock protein70, Casein kinases, Plasmepsin IV, and Brucipain. Hsp70 and casein kinase II alpha were characterized in-silico. Altogether, these results provide a reference database in understanding AO molecular biology, aiding to the development of novel diagnostics and future vaccines.
Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity
Authors: S. Udhaya Kumar , Rajan Bithia , D. Thirumal Kumar , V. Anu Preethi , Abunada Taghreed , Younes Salma , Okashah Sarah , Ethiraj Selvarajan , C. George Priya Doss , Zayed Hatem
Published: October 2020

(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious health problem that is associated with an increased risk of premature heart attack, stroke, and death. To date, a key challenge has been to understand the molecular pathways that play significant roles in diabesity. In this study, we aimed to investigate the genetic links between diabetes and obesity in diabetic individuals and highlight the role(s) of shared genes in individuals with diabesity. (2) Methods: The interactions between the genes were analyzed using the Search Tool for the Retrieval of Interacting Genes (STRING) tool after the compilation of obesity genes associated with type 1 diabetes (T1D), type 2 diabetes (T2D), and maturity-onset diabetes of the young (MODY). Cytoscape plugins were utilized for enrichment analysis. (3) Results: We identified 546 obesity genes that are associated with T1D, T2D, and MODY. The network backbone of the identified genes comprised 514 nodes and 4126 edges with an estimated clustering coefficient of 0.242. The Molecular Complex Detection (MCODE) generated three clusters with a score of 33.61, 16.788, and 6.783, each. The highest-scoring nodes of the clusters were AGT, FGB, and LDLR genes. The genes from cluster 1 were enriched in FOXO-mediated transcription of oxidative stress, renin secretion, and regulation of lipolysis in adipocytes. The cluster 2 genes enriched in Src homology 2 domain-containing (SHC)-related events triggered by IGF1R, regulation of lipolysis in adipocytes, and GRB2: SOS produce a link to mitogen-activated protein kinase (MAPK) signaling for integrins. The cluster 3 genes ere enriched in IGF1R signaling cascade and insulin signaling pathway. (4) Conclusion: This study presents a platform to discover potential targets for diabesity treatment and helps in understanding the molecular mechanism.
5HTTLPR Genetic Variant and Major Depressive Disorder: A Review
Authors: Fratelli Caroline , Siqueira Jhon , Silva Calliandra , Ferreira Eduardo , Silva Izabel
Published: October 2020

Major Depressive Disorder (MDD) is a disease that involves biological, psychological, and social interactions. Studies have shown the importance of genetics contribution to MDD development. The SCL6A4 protein (5HTTLPR) functions transporting serotonin, a neurotransmitter linked to mood and emotion, to the synaptic cleft. Hence, this study seeks, through a literature review, a better comprehension of the 5HTTLPR genetic variant association with MDD. For this purpose, a search was performed on the Virtual Health Library Portal for articles that related 5HTTLPR to MDD. Most of the articles found were conducted in the American continent, with one (1) study implemented in Brazil. 5HTTLPR associations were found regarding changes in the nervous system, pharmacology, and risk factors seen in MDD patients. When verifying the allelic distribution, the S allele had a higher frequency in most of the studies analyzed. Despite not finding a commonality in the different studies, the tremendous genetic variation found demonstrates the MDD complexity. For this reason, further studies in diverse populations should be conducted to assist in the understanding and treatment of the disease.
Digital Health Applications for Pharmacogenetic Clinical Trials
Authors: Naik Hetanshi , Palaniappan Latha , Ashley Euan A. , Scott Stuart A.
Published: October 2020

Digital health (DH) is the use of digital technologies and data analytics to understand health-related behaviors and enhance personalized clinical care. DH is increasingly being used in clinical trials, and an important field that could potentially benefit from incorporating DH into trial design is pharmacogenetics. Prospective pharmacogenetic trials typically compare a standard care arm to a pharmacogenetic-guided therapeutic arm. These trials often require large sample sizes, are challenging to recruit into, lack patient diversity, and can have complicated workflows to deliver therapeutic interventions to both investigators and patients. Importantly, the use of DH technologies could mitigate these challenges and improve pharmacogenetic trial design and operation. Some DH use cases include (1) automatic electronic health record-based patient screening and recruitment; (2) interactive websites for participant engagement; (3) home- and tele-health visits for patient convenience (e.g., samples for lab tests, physical exams, medication administration); (4) healthcare apps to collect patient-reported outcomes, adverse events and concomitant medications, and to deliver therapeutic information to patients; and (5) wearable devices to collect vital signs, electrocardiograms, sleep quality, and other discrete clinical variables. Given that pharmacogenetic trials are inherently challenging to conduct, future pharmacogenetic utility studies should consider implementing DH technologies and trial methodologies into their design and operation.
Transcription Factors of the bHLH Family Delineate Vertebrate Landmarks in the Nervous System of a Simple Chordate
Authors: Negrón-Piñeiro Lenny J. , Wu Yushi , Di Gregorio Anna
Published: October 2020

Tunicates are marine invertebrates whose tadpole-like larvae feature a highly simplified version of the chordate body plan. Similar to their distant vertebrate relatives, tunicate larvae develop a regionalized central nervous system and form distinct neural structures, which include a rostral sensory vesicle, a motor ganglion, and a caudal nerve cord. The sensory vesicle contains a photoreceptive complex and a statocyst, and based on the comparable expression patterns of evolutionarily conserved marker genes, it is believed to include proto-hypothalamic and proto-retinal territories. The evolutionarily conserved molecular fingerprints of these landmarks of the vertebrate brain consist of genes encoding for different transcription factors, and of the gene batteries that they control, and include several members of the bHLH family. Here we review the complement of bHLH genes present in the streamlined genome of the tunicate Ciona robusta and their current classification, and summarize recent studies on proneural bHLH transcription factors and their expression territories. We discuss the possible roles of bHLH genes in establishing the molecular compartmentalization of the enticing nervous system of this unassuming chordate.
Clinical Communication Skills Training in Dental Medical Education: The COVID-19 Pandemic Challenge
Authors: Salgado Henrique , Castro-Vale Ivone
Published: October 2020

It is very important for healthcare professionals to have good clinical communication skills, especially dentists. Patient-centred care results in patient satisfaction, better outcomes, and less complaints from dental patients. Due to the onset of the COVID-19 pandemic, the clinical communications skills programme of the pre-graduate course in dental medicine at the University of Porto had to be transformed to an online format. Based on their role as faculty, the authors aimed to recount their initial reflections and concerns within this perspective, and to share how they adapted to the new reality of teaching clinical communication skills online, as well as the conclusions of our experience, in the hope that this will help others who may have to go through a similar process. The authors acknowledged that the students achieved the pre-established goals of the clinical communications skills programme through the new online format.
Relationship of Body Composition with the Strength and Functional Capacity of People over 70 Years
Authors: Patiño-Villada Fredy Alonso , González-Bernal Jerónimo J , González-Santos Josefa , de Paz José Antonio , Jahouh Maha , Mielgo-Ayuso Juan , Romero-Pérez Ena Monserrat , Soto-Cámara Raúl
Published: October 2020

Background: Aging is a multifactorial physiological phenomenon, in which a series of changes in the body composition occur, such as a decrease in muscle mass and bone mineral density and an increase in fat mass. This study aimed to determine the relationship of muscle mass, osteoporosis, and obesity with the strength and functional capacity of non-dependent people over 70 years of age. Methods: A cross-sectional study was designed, whose study population was all people aged over 70 years, living independently and attending academic and recreational programs. Muscle strength and functional capacity of the participants were assessed by isometric exercises of lower and upper limbs and by four tests taken from the Senior Fitness Test, respectively. Bone mineral density, total mass, fat mass, total lean mass, arms lean mass, legs lean mass, and appendicular lean mass (ALM) was calculated by dual energy X-ray absorptiometry. Differences in muscle strength and functional capacity, according to the sex, muscle mass, mineral bone density and fat mass, were measured by χ2 test, independent samples Student’s t-test, analysis of covariance and a 2-factor analysis of covariance; Results: 143 subjects were included in the study group. Men and women with an adequate amount of ALM adjusted for body mass index (BMI) had a maximal dynamic biceps strength in a single repetition, a maximal isometric leg extension strength, a maximal dynamic leg extension strength in a single repetition, a maximum right hand grip strength and maximum hand grip strength (the highest). Significantly higher values were observed in the maximal isometric biceps’ strength in men with osteoporosis. Obese men had less isometric strength in the biceps and took longer to perform the chair stand test; Conclusions: Men and women with an adequate amount of ALM adjusted for BMI obtained better results in tests of muscle strength and functional capacity. However, osteoporosis and obesity are not related to these parameters.
The Impact of the COVID-19 Pandemic on the Quality of Educational Process: A Student Survey
Authors: Radu Maria-Crina , Schnakovszky Carol , Herghelegiu Eugen , Ciubotariu Vlad-Andrei , Cristea Ion
Published: October 2020

The paper presents the results of a students’ survey carried out at “Vasile Alecsandri” University of Bacau, Romania, on the quality of educational process on online platforms in the context of the COVID-19 pandemic. The study was addressed to students from the Faculty of Engineering and the Faculty of Physical Education and Sports. The results of survey highlighted that most of students were satisfied with the measures taken by the university during the lockdown period and the way the teaching—learning-assessment process took place. However, some negative aspects were reported as: lack of an adequate infrastructure for some students, less effective teacher-student communication and interaction, impossibility of performing practical applications, lack of socialization, lack of learning motivation, less objective examination (e.g., possibility of cheating), possibility of physical and mental health degradation (e.g., too much time spent in front of screens, installation of a sedentary lifestyle). Consequently, for the new academic year, effective, and efficient measures must be implemented by the management of the university to remove, as much as possible, these negative issues and to improve the performance of online educational process.
The Quality of Work Index and the Quality of Employment Index: A Multidimensional Approach of Job Quality and Its Links to Well-Being at Work
Authors: Steffgen Georges , Sischka Philipp E. , Fernandez de Henestrosa Martha
Published: October 2020

(1) Background: Job quality is a multidimensional and elusive concept that is back in vogue among social scientists and policymaker. The current study proposes a new job quality approach that is compared with the European Working Conditions Survey framework and structured with the help of the Job Demands-Resources model. Two new measures of job quality, the Quality of Work Index (QoW) and the Quality of Employment Index (QoE) are developed and validated in three different languages (German, French, Luxembourgish). The QoW is composed of 43 items, focusing on four areas of work—work intensity, job design, social conditions, and physical conditions (subdivided in eleven components)—which are particularly important for employees’ well-being. The QoE is composed of 13 items that cover training opportunities, career advancement, job security, employability, work life conflict, and income satisfaction. (2) Methods: Data were collected via computer-assisted telephone interviews in a representative sample of 1522 employees working in Luxembourg (aged 17–67 years; 57.2% male). (3) Results: Confirmatory factor analysis confirmed the proposed factors structure and scalar measurement invariance for the three different language versions. Internal consistencies were satisfactory for all subscales (Cronbach’s α between 0.70 and 0.87). Correlations and hierarchical regression analyses with different psychological health measures (i.e., burnout, general well-being, psychosomatic complaints, work satisfaction, vigor) and subjective work performance confirmed the construct validity of the new instruments. (4) Conclusions: The QoW and the QoE are globally and on the level of the sub-categories effective tools to measure job quality, which could be used to compare job quality between organizations and different countries. Furthermore, the current study confirms associations between the different components of the QoW and QoE and employees’ health.
Well-Being without Employment? Promoting the Employability of Refugees
Authors: Llinares-Insa Lucía I. , Roldán-Pardo Manuel , González-Navarro Pilar , Benedito-Monleón María Desamparados
Published: October 2020

There are more than 25 million refugees in the world. Many of them try to reach the Mediterranean in order to enter Europe. Spain is one of the countries that receive refugees and have to integrate them. Many refugees have experienced persecution in their countries, as well as forced migration, rape, diseases, etc. Their integration requires support and coordination from the government, health services, and social agents. The first step in achieving this integration is getting a job, which is currently an important issue. Thus, we aim to analyze the employability of a specific group of refugees in Spain and then develop and implement an intervention program to improve their employability. Our framework is based on the Bioecological Model of Employability. The results obtained show that the program is effective in improving employability, and they highlight the importance of labor inclusion for refugees’ well-being. Moreover, the findings reveal the need to create labor market policies and further evaluations, diagnostics, and intervention programs that improve employability and other types of personal-community growth. It is necessary to focus on refugees’ needs and develop appropriate services.
Evidence of Low-Habitat Contamination Using Feathers of Three Heron Species as a Biomonitor of Inorganic Elemental Pollution
Authors: Canova Luca , Sturini Michela , Profumo Antonella , Maraschi Federica
Published: October 2020

The concentration of 12 elements (As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se, and Zn) has been investigated in the feathers of three species of Ardeidae, namely the Grey Heron Ardea cinerea, the Little Egret Egretta garzetta, and the Cattle Egret Bubulcus ibis, all breeding at a colony located in the southern Padana Plain (NW Italy). This study is a first step for an evaluation of possible direct effects of these elements on chicks’ survival and growth rate. Fe, Zn, Cu, and Mn were in the range 7–69 mg Kg−1, while lower levels of Pb, Ni, As, and Se (0.27–1.45 mg Kg−1) were measured. Co, Cd, and Cr were close to the method detection limits (MDLs) in all the species. The measured concentrations of the most abundant trace elements, such as Zn and Cu, seem to reflect the geochemical pattern of the background (running water and soil), while Hg concentration is lower and it appears to be biomagnified, particularly in Grey Heron feathers. Its concentration is higher in adults than in chicks, and it differs among the three species, as it is closely related to the fish-based dietary pattern. The measured trace elements’ concentrations are below the threshold levels in all the heron species, and consequently, harmful and acute effects on the local population are unlikely; the conservation status of herons populations in northern Italy is probably more affected by other factors, such as climate changes, altered aquatic environment, and, consequently, food quality.
Method for Quantifying Variation in the Resistance of Electronic Cigarette Coils
Authors: Saleh Qutaiba M. , Hensel Edward C. , Robinson Risa J.
Published: October 2020

In electronic nicotine delivery systems (ENDS), coil resistance is an important factor in the generation of heat energy used to change e-liquid into vapor. An accurate and unbiased method for testing coil resistance is vital for understanding its effect on emissions and reporting results that are comparable across different types and brands of ENDS and measured in different laboratories. This study proposes a robust, accurate and unbiased method for measuring coil resistance. An apparatus is used which mimics the geometric configuration and assembly of ENDS reservoirs, coils and power control units. The method is demonstrated on two commonly used ENDS devices—the ALTO by Vuse and JUUL. Analysis shows that the proposed method is stable and reliable. The two-wire configuration introduced a positive measurement bias of 0.086 (Ω), which is a significant error for sub-ohm coil designs. The four-wire configuration is far less prone to bias error and is recommended for universal adoption. We observed a significant difference in the coil resistance of 0.593 (Ω) (p < 0.001) between the two products tested. The mean resistance and standard deviation of the reservoir/coil assemblies was shown to be 1.031 (0.067) (Ω) for ALTO and 1.624 (0.033) (Ω) for JUUL. The variation in coil resistance between products and within products can have significant impacts on aerosol emissions.