bluuebunny/crossref_metadata_2025 huggingface dataset:
Multidisciplinary Management of the Patient with Knee Endoprosthetics. A Case Report
Authors: Nadezhda Vladimirovna Zhuravleva , Valentina Nikolaevna Diomidova , Nadezhda Dmitrievna Ukhterova , Evgenia Arkadievna Guryanova , Tatyana Lvovna Smirnova , Andrey Valerievich Vlasov
Published: November 2023

The most commonly diagnosed type of arthritis is osteoarthritis (OA) of the knee joint, the incidence of which constantly increases with increasing life expectancy. Theaim of this case study is the multidisciplinary management of the patient with knee endoprosthetics. The case was defined as the right knee joint's osteoarthritis operative treatmentand rehabilitation. A 64-year-old -male patient complained of right-sided stage III idiopathic gonarthrosis. The patient passed the general blood analysis, biochemical blood analysis,coagulogram, and urine analysis. The patient passed the ultrasound low limbs veins examination. The total right knee endoprosthesis with the implantation was done. The prosthesiscomponents as Journey II BCS Femoral Component Right 4, Tibial component Journey Right 4, and liner Journey II BCS XLPE Right 10 mm 3-4 were fixed to the male patient. Thepatient's rehabilitation period passed through three stages: III, idiopathic gonarthrosis with various deformities of the right lower limb; stage III, patellofemoral arthrosis, synovitis ofthe right knee joint, osteoporosis, complicated joint insufficiency, and stage III. The male patient was prescribed the non-steroidal anti-inflammatory drugs (NSAIDs). The male patientreceived the treatment with the hyaluronic acid. The male patient had no improvement results for four years, and the pharmacological treatment was unsuccessful. The prosthesiscomponents are Journey II BCS Femoral Component Right 4, Tibial component Journey Right 4, and liner Journey II BCS XLPE Right 10 mm 3-4 fixed to the male patient. Physicalrehabilitation after the total knee endoprosthetic was performed several stages after surgery. Stage one - immediately after surgery during the first 5 days. Stage two – the clinicalstage in the early recovery period. Stage three - after the hospital during the first 3 months. After 6 months, the male patient was allowed to walk without the additional support.He was restricted from lifting weights and preventing falls. A year after the operation, the right knee joint movements' amplitude was sufficient, and there was no pain syndrome.Total knee endoprosthesis leads to high patient satisfaction and provides patients with life-quality benefits, pain relief, and function. The patient's rehabilitation period, includingphysical exercises and physiotherapy, is a very important stage. Effective patient rehabilitation after knee endoprosthetics is possible using multidisciplinary management.
ESTADO NUTRICIONAL E TEMPO DE INTERNAÇÃO DE PACIENTES COM COVID-19: REVISÃO INTEGRATIVA
Authors: Morgenstern Daiane , Bruch-Bertani Juliana Paula
Published: November 2023

Este estudo teve como objetivo avaliar o estado nutricional, o tempo de internação e desfechos clínicos de pacientes acometidos pela Covid-19. A pesquisa foi realizada através de uma revisão integrativa sobre o assunto nas bases de dados Scielo, PubMed e Google Scholar em que utilizou-se os descritores: “nutritional status and Covid-19”, length of stay and Covid-19”, “hospital malnutrition and Covid-19”. Realizou-se uma primeira análise de títulos, sendo selecionados 147 artigos. Em uma segunda análise, foi realizado a leitura dos resumos para obtenção de artigos potencialmente relevantes para o estudo, sendo selecionados 63 e posteriormente feita leitura integral dos artigos, sendo escolhidos 12 para fazer parte desta revisão por atenderem a todos os critérios de inclusão e ao objetivo do estudo. Pacientes em estado de desnutrição apresentam maior tempo de permanência hospitalar quando comparados aos pacientes em estado de eutrofia. Verificou-se que paciente que apresentam baixos níveis de hemoglobina refletiram em uma média de tempo de permanência hospitalar de 10,5 dias, ainda, a maioria apresentou risco nutricional e consequentemente maior tempo de internação. Verificou-se também que, pacientes enfermos com COVID-19 em estado de desnutrição moderada no momento da admissão hospitalar estão propensos a evolução do quadro para desnutrição grave, permanecendo em média 23 dias de internação. Assim, foi possível verificar que o estado nutricional dos pacientes acometidos pela Covid-19 pode estar relacionado a maior tempo de internação hospitalar.
OBSERVAÇÕES SOBRE A REPRODUÇÃO DE UM CASAL DE Geranoaetus melanoleucus (AVES: ACCIPITRIDAE) NO SUL DO BRASIL
Authors: Cappellari Lize Helena , Corrêa Luiz Liberato Costa , Santos Raphael Eduardo Fernandes , Balestrin Rafael Lucchesi
Published: November 2023

Neste estudo descrevemos observações de um casal de águia-serrana (Geranoaetus melanoleucus), obtidas entre o mês de dezembro do ano de 2015 e março de 2020. Neste período foram registradas duas estações reprodutivas com a confecção de ninhos em árvores exóticas de Eucalyptus sp, localizadas em área campestre alterada por atividades agrícolas, às margens da BR 293, no bioma Pampa, município de Dom Pedrito, estado do Rio Grande do Sul, Brasil. Sugere-se que a postura dos ovos ocorra no mês de setembro nesta região, tendo sido detectados jovens já bem constituídos nos meses de novembro, os quais deixaram o ninho no mês de dezembro. A importância destes registros destaca-se por auxiliar na caracterização da plasticidade ambiental da espécie, contribuindo com informações sobre a história natural da espécie na literatura especializada, bem como por fornecer informações pertinentes para sua conservação na região.
INTERAÇÕES MEDICAMENTOSAS EM PACIENTES DE HEMODIÁLISE: UMA ABORDAGEM FARMACÊUTICA
Authors: Pinto dos Santos Juan Victor , Fernandes Daniel Das Neves , Souza Larissa Leite de , Silva Dayvid Batista da
Published: November 2023

A doença renal crônica é uma enfermidade que vem crescendo cada vez mais na população, sendo causada por algumas patologias como hipertensão arterial, diabete mellitus e também pelo envelhecimento. O objetivo do presente trabalho é realizar uma abordagem farmacêutica em relação as principais interações medicamentosas frente ao tratamento dos pacientes hemodialíticos. Nesse estudo foi realizada uma revisão de literatura, onde foi realizada uma busca nos principais bancos de dados como SCIELO, Science Direct, PUBMED, Periódico CAPES e LILACS utilizando os descritores “Doença renal crônica”, “Chronic kidney disease”, “Interações medicamentosas”, “Drug interactions”, Atenção farmacêutica” e “Pharmaceutical care”. A inclusão dos artigos selecionados compreendeu os últimos 4 anos, ou seja, de 2019 à 2023, utilizando artigo nacionais e internacionais. A partir da análise de 10 artigos, foram elencadas as principais medicações e interações medicamentosas dos fármacos Ácido Acetilsalicílico, Furosemida, Omeprazol, Besilato de Anlodipino, Sinvastatina, Suplementação de Ferro, Carbonato de Cálcio, Losartana, Atenolol e Insulina dos pacientes em hemodiálise, evidenciando o papel e importância do farmacêutico dentro da equipe multidisciplinar de saúde, disseminando o conhecimento acerca das interações clínicas e sobre a terapia farmacológica.
CARACTERÍSTICAS IMPORTANTES PARA O PERFIL DO PROFISSIONAL DE EDUCAÇÃO FÍSICA ATUANTE NO TREINAMENTO DE FORÇA SEGUNDO OS FREQUENTADORES DE ACADEMIAS
Authors: Lazzaretti Kely , Tiggemann Carlos Leandro
Published: November 2023

A atividade física é importante para a promoção da saúde e a qualidade de vida, e atualmente uma das atividades mais populares é o treinamento de força. Entender como os frequentadores desta modalidade avaliam como deve ser o perfil do profissional de Educação Física que atua neste ambiente é de grande importância. Desta forma, o presente estudo tem por objetivo avaliar quais são as características mais importantes para um profissional de Educação Física que trabalha na área do treinamento de força, segundo os frequentadores de academias. Trata-se de um estudo quantitativo e de natureza transversal descritiva. A pesquisa foi realizada por meio do aplicativo Google Forms, através de um questionário online elaborado pelos pesquisadores, com um total de 33 perguntas relacionadas aos seus dados pessoais, referentes à academia que frequentam e sobre quais são as características mais importantes para um profissional de Educação Física que trabalha na área do treinamento de força, do qual 198 sujeitos adultos jovens e moradores do Vale do Taquari e região participaram, sendo 62,6% mulheres e 37,4% homens, com idade entre 18 a 59 anos. Como resultado desta pesquisa, as características mais importantes para o perfil do profissional de Educação Física que trabalha na área do treinamento de força, são todas relacionadas à qualidade dos serviços prestados e à forma que o profissional se comporta com seus alunos. Os quatro aspectos considerados mais relevantes pelos participantes da pesquisa, é saber corrigir a execução dos exercícios, demonstrar conhecimento técnico e científico, ter qualidade na montagem dos treinamentos e nas orientações gerais. Sendo assim, este estudo pode ajudar os profissionais dessa área a se adequar aos aspectos que são considerados essenciais pelos clientes, motivando-os a melhorar seu desempenho nos treinamentos, recebendo mais alunos e fidelizando-os.
Geographic and income dispersions of at-risk students, what determinants does the features importance analysis tell us?
Authors: OUAADI Ismail , IBOURK Aomar
Published: November 2023

Currently the amount of available and variety of data constitute a
challenging purpose of decision makers, especially in education field.
This article aims to predict a specific kind of students that reveal
many concerns in all countries. These students are qualified as low
educational skills attainment and named at-risk students in some
literature. This objective is pursued given the countries classification
by regional and income belonging. As methodology, we have used six
machine learning algorithms, six models’ performance evaluation metrics,
three labels and seven features. The relevance of these features is
assessed via feature importance analysis technics in intention to
exploit them in models’ construction and training. Results shown, first
that some models perform very well than other given countries
classification either by region or by income according to three
performance metrics. Second, models fitted with African countries data
are more performant and accurate than the other models given all
performance metrics. Third, some features are important than other in
the model training phase. Finally, we conclude that using other machine
learning parameters and computing powers can lead to performance
enhancement of the adopted models.
Strangulation of the small colon by ovarian pedicle in an adult broodmare
Authors: Claunch Kevin , Wurst Parker , Chisholm Cari
Published: November 2023

A 17-year-old Quarter Horse broodmare was taken to surgery for signs of
colic unresponsive to medical management. The small colon was
strangulated by a pendulous ovarian pedicle. The strangulation was
freed, and the affected ovary was removed. The mare developed signs of a
small colon obstruction 4 days after surgery. The mare was euthanized 6
days after surgery for signs of a GI rupture. A post-mortem examination
revealed necrosis of the affected portion of small colon.
The anisotropic interior transmission eigenvalue problem with a conductive boundary
Authors: Harris Isaac , Hughes Victor , Sun Jiguang
Published: November 2023

In this paper, we study the transmission eigenvalue problem for an
anisotropic material with a conductive boundary. We prove that the
transmission eigenvalues for this problem exist and are at most a
discrete set. We also study the dependence of the transmission
eigenvalues on the physical parameters and prove that the first
transmission eigenvalue is monotonic. We then consider the limiting
behavior of the transmission eigenvalues as the conductive boundary
parameter η vanishes or goes to infinity in magnitude. Finally,
we provide some numerical examples on three different domains to
demonstrate our theoretical results.
Research and practice on rapid outburst elimination technology for gas extraction blank zone in working face with large mining length
Authors: Su Dengfeng , Zheng Dandan , Zhu Qiang , Zhao Li , Wang Rui , Cheng Rongkai
Published: November 2023

Gas extraction blank zones are common safety hazards for large-long
working faces. The elimination rate of the gas extraction blank zone
significantly influences the production of large-long working faces. In
this study, the technical principle of rapid outburst elimination
technology for gas extraction blank zones in large mining faces was
described. A three-dimensional numerical simulation of the pressure
relief effect by water jet slotting was performed, and a field
industrial test of rapid outburst elimination technology for gas
extraction blank zones in working faces with large mining lengths was
conducted in the No. 10 mine of China Pingmei Shenma Group. The results
indicated that the method of drilling boreholes through the floor in the
bed plate roadway and using high-pressure water jet slotting technology
proved to be a rapid outburst elimination technology for gas extraction
blank zones in large mining faces. This can provide a reference for
similar projects.
Heterotic patterns in rapeseed (Brassica napus L.): Crosses between spring-type and winter-type genotypes
Authors: Rameeh Valiollah
Published: November 2023

Genetic improvement in a crop, viz. Brassica species, through plant breeding
essentially requires the presence of adequate genetic diversity within the
gene pool. Winter rapeseed is known to be genetically different from spring
rapeseed and can therefore be used for extending genetic diversity in the
progenies produced via crossing methods. Using line?tester analyses of two
spring types of testers and six lines of winter-type rapeseed varieties,
heterotic patterns of phenological traits, plant height and seed yield were
estimated. Significant mean squares between parents and crosses revealed
significant heterosis for all the traits. Line?tester mean squares,
indicating the non-additive genetic effects, were significant only for plant
height and seed yield. High narrow-sense heritability estimates for
phenological traits underline the importance of additive genetic effects and
thus the efficiency of selection for improving these traits. Based on the
significant and positive expression of heterosis effects for phenological
traits and plant height in the winter parents, it was concluded that the F1
progenies had earlier and shorter maturity than the winter parents. F1
progenies were also early flowering, early maturing and taller than the
spring-type parents. Significant positive heterosis of the crosses for seed
yield was observed in 75% and 42% of F1 progenies compared to the spring and
winter parents, respectively, indicating a higher yield potential of the F1
hybrids than the spring and winter parents.
A comparative study on narbon vetch and common vetch in the semi-arid region of Setif (Algeria)
Authors: Mahmah Selma , Mebarkia Amar , Rekik Fouad
Published: November 2023

Algeria has a limited supply of fodder. Traditional methods of raising
livestock rely on the exploitation of low-quality rangelands, fallow and
natural pastures with forage crops receiving little attention. The
population relies on imports to meet its protein needs. Indeed, fodder
production is the primary lever for improving livestock nutrition and, as a
result, the productivity of the livestock systems in question. It is also
crucial to the sustainability of mixed systems that combine plant and animal
production. The current study was conducted to evaluate the phenological
stages, analyze the performances of fodder yield, grain yield and some of
its components and determine the chemical composition of the species Vicia
narbonensis L. in comparison with Vicia sativa L. in order to improve the
fallow year in the cereal/fallow rotation and develop the marginal lands.
Trials were conducted on the plots of FERHAT Abbas University Campus under
the rainfed conditions in the semi-arid region of Setif during three growing
seasons (2017-2020), using 10 ecotypes of narbon vetch and 2 ecotypes of
common vetch (as control ecotypes) in a randomized complete block design
with three replicates. Significant effects of the ecotype, the year and the
ecotype x year interaction were found, as well as a great variability in the
phenological stages, agronomic characteristics and chemical composition of
the ecotypes studied. A significant positive relationship (p<0.05) was found
between grain yield and dry matter yield and a significant negative
relationship (p<0.05) was found between full flowering date and dry matter
yield and grain yield. It seems that the early flowering ecotypes produce
better yields than the late flowering ones in the semi-arid region of Setif.
Morphology and molecular characterization of Tylenchulus semipenetrans from citrus orchards in northern Iran
Authors: Asadi Seyedeh , Jamali Salar , Ghadamyari Mohammad , Motaghitalab Vahid
Published: November 2023

Tylenchulus semipenetrans Cobb, 1913 is among some of the most economically
important plant-parasitic nematodes in the world. The nematode has been
identified as the causal agent of slow decline. Most studies estimate the
yield losses, due to T. semipenetrans, to range from 10% to 30%, depending
on the level of infection, aggressiveness of the nematode population, soil
characteristics, susceptibility of the rootstock, presence of other
pathogens and grove management practices. In order to identify the citrus
nematode in northern Iran, soil and root samples were collected from
infected trees. The second-stage juveniles were isolated from the soils by
the tray method. Eggs and females were extracted from roots by the
centrifugal-flotation technique. Morphological observations and molecular
evidence confirmed this population as T. semipenetrans. A phylogenetic tree
of T. semipenetrans populations was reconstructed based on 28S rRNA gene
sequences using RAxML. Morphologically, there is a slight difference between
the studied population and the reported populations of T. semipenetrans from
pomegranate and banana orchards in southern Iran. Phylogenetic analysis
showed the close relationship of the T. semipenetrans population from
northern Iran with other populations of this species. Based on molecular
analysis, Tylenchulus was identified as a monophyletic group. The
phylogenetic position and measurements of T. semipenetrans were provided.
An empirical study on assessment of trend analysis: Food grain production in India
Authors: Polisetty Kalpana , Chesneau Christophe , Paltati Gowthami , Paidipati Kiran
Published: November 2023

Considering the importance of the food grains to be specified-rice, wheat,
coarse cereals, and pulses-is vital in developing the Indian economy. This
paper carries out change point detection and trend analysis for the annual
historical series of food grains in India. The change points were identified
by the methods of the Pettitt?s test (PT), the Buishand?s range test (BRT),
and the standard normal homogeneity test (SNHT). On the other hand, the
Mann-Kendall (MK) test was used to determine the presence and absence of
trends in food grain production, and their slopes were assessed by the Sen?s
slope estimator. The change point analysis result shows significant change
points for food grains at a 95% level. The discrete change points were
observed from 1982 to 2009, but the ideal change point, i.e., 1987, was
captured in all food grains. In India?s history, agricultural production in
the year 1987 was vulnerable due to drought, and thus it is strong evidence
of the need to consider methods based on proven facts. The MK test results
reveal that the trend in food grain production was statistically significant
and had an upward direction in all three segmentation periods after 1987.
Performance enhancement of water output via latent heat storage system with single slope solar stills
Authors: Velumayil Ramesh , Seikh Asiful , Balasubramanian Vedagiri , Kalam Md. , Ravishankar Sathyamurthy , Venugopal Jayaprakash , Chitra Lakshmikanthan , Saravanakumar Lakshmanasamy , Senthilkumar T.S.
Published: November 2023

The purpose of this study was to design, build, and assess the performance of a latent heat storage system in tandem with a single slope solar still. Using a solar accumulator to transfer hot water to a shell and a spiral finned tube filled with 30 kg of paraffin wax ? 1.2 wt.% of Al2O3 nanocomposites, latent heat was stored. To test the effect of the storage system?s performance, two trials were conducted, with and without storage, under as similar of conditions as could be arranged. The proposed storage system design eliminates any potential issues with usage of paraffin wax as the storage system in conjunction with the solar still. An outcome indicated that daily fresh water output was enhanced by 4.63% when the solar still was used in conjunction with the storage system.
Variability of carbon emission factors from lignite of the Kostolac basin in time
Authors: Zivkovic Nikola , Cvetinovic Dejan , Eric Aleksandar , Bakic Vukman , Skobalj Predrag
Published: November 2023

This paper presents experimental tests of lignite from the Kostolac open-pit mine, used to operate the boiler of the Kostolac B2 thermal power plant in 2022. Experimental tests were conducted to determine the emission characteristics and carbon emission factor and compare these values with those taken and determined in 2016. A total of 31 samples taken in April 2022 were tested. As with our previous work, the experimental methodology includes proximate analysis, ultimate analysis and determination of calorific value, for the ?as received?, ?as determined? and 'dry basis'. Corresponding correlations were established for the tested Kostolac lignite. The emission characteristics of the Kostolac lignite from 2022 were compared with the corresponding values from 2016. Certain changes in the values of the carbon emission factor over time are a regular phenomenon and therefore, periodic sampling and experimental determinations are inevitable to follow the changes in the values. For this change in coal properties, new values for the carbon emission factor are proposed, which should be used to calculate the total carbon dioxide emissions in the last period.
relação entre a oralidade e escrita e sua implicação na clínica fonoaudiológica sob diferentes perspectivas teóricas
Authors: Coltro Karen Camila , Marcolino-Galli Juliana , Cordeiro Michelly Daiane de Souza Gaspar , Aspilicueta Patrícia
Published: November 2023

Introdução: Este trabalho diferencia três abordagens teóricas que, comumente, sustentam a prática fonoaudiológica na área da linguagem. O foco é a relação entre oralidade e escrita e sua implicação nos procedimentos clínicos nos distúrbios ou dificuldades de leitura e escrita. Objetivo: apresentar e analisar a relação entre a oralidade e a escrita e discutir como a clínica fonoaudiológica conduz o tratamento ou o acompanhamento de crianças com distúrbios na linguagem escrita em diferentes perspectivas teóricas. Método: Trata-se de uma revisão integrativa da literatura. Foram selecionados dezesseis artigos que respondem às questões de pesquisa nas seguintes abordagens: Cognitivo-Linguística, Enunciativo-Discursiva e Clínica de Linguagem (Linguístico-Discursiva). Resultados: Nota-se diferentes interpretações clínicas para a prevenção, os critérios diagnósticos, nomenclatura e método de tratamento. Conclusão: As diferentes posições teóricas definem modelos de clínicas distintos, considerando como a oralidade pode afetar a escrita.
Wallach’s Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis
Authors: Soodoi Chimidtseren
Published: November 2023

No absract in English
Detection of H275Y Mutation of A(H1N1)pdmO9 Viruses Using a Real-time RT-PCR Assay in Mongolia
Authors: Tsedenbal Naranzul , Badarch Darmaa , Jav Sarantuya , Pagbajav Nymadawa
Published: November 2023

Objectives: Oseltamivir is recommended as a first-line drug for the prophylaxis and treatment of influenza A(H1N1)pdmO9 infection worldwide. However, oseltamivir-resistant influenza A(H1N1)pdmO9 viruses have been identified and are mostly associated with an H275Y substitution in the neuraminidase (NA) gene. Careful and rapid laboratory testing for antiviral resistance surveillance of influenza viruses are important to public health and clinical sectors. The aim of our study was to determine oseltamivir-resistant H275Y mutation in clinical specimens by the real-time reverse transcriptase polymerase chain reaction (rtRT-PCR) assay in Mongolia. Methods: A total of 215 clinical specimens tested positive for the A(H1N1)pdmO9 influenza virus by rtRT-PCR. The specimens were collected between January 2013 and August 2014 from patients who visited influenza surveillance sites. All collected specimens were tested for the presence of the oseltamivir-resistant H275Y mutation by rtRT-PCR and DNA sequencing on the NA gene was performed on four of the clinical samples. Results: For all specimens, the H275 (Ct value = 20.4-34.5) was sensitive to oseltamivir by rtRT-PCR assay for detection of the H275Y mutations in the NA gene. Four questionable clinical samples were sequenced for the full NA gene. The data of these samples are available in GISAID influenza virus database with accession numbers EPI533542, EPI462274, EPI462271 and EPI460844. Conclusion: The A(H1 N1)pdm09 viruses were susceptible to oseltamivir during the study period in Mongolia. The rtRT-PCR assay is useful for detection of the H275Y substitution but other possible mutations in the NA gene of the virus could limit the utility of this technique.
Clarithromycin Resistance in Helicobacter Pylori
Authors: Bolor-Erdene Mandkhai , Namdag Bira , Jav Sarantuya
Published: November 2023

Objectives: Eradication rates of Helicobacter pylori with standard triple therapy are disappointing in studies from several countries. The main reason for failure was found to be bacterial resistance to one of the most commonly used antibiotics, clarithromycin. Our aim was to determine the prevalence of clarithromycin resistance among H. pylori strains isolated from Mongolians and the presence of associated mutations to these antibiotics. Methods: All urease-positive samples were cultured according to the standard microbiological procedures. H. pylori strains were grown under microaerophilic conditions on H. pyloriselective agar. H. pylori antibiotic sensitivity was examined using the E-test method. The GenoType HelicoDR, which employs reverse hybridization, was used to confirm the presence of H. pylori, determine its susceptibility to antimicrobials and detect mutations conferring resistance to clarithromycin. Results: Ourfindings show that 51 (53.7%) ofH. pyloristrains were resistantto clarithromycin. Mutations were observed in 32 (53.7%) strains with A2147G being the most prevalent, A2146G being the least prevalent and A2146C point mutation being undetected. Conclusion: In the present study, H. pylori strains with moderate-level clarithromycin resistance are more frequently found and clarithromycin is associated with point mutation A2147G in Mongolians.
Study on the Mutation Sites of CSF3R Responsible for the Clonal Advantage of Chronic Neutrophilic Leukemia
Authors: Altangerel Otgonbat , Zhao Ming Feng , Mao Wu Ri
Published: November 2023

Objectives: Chronic neutrophilic leukemia (CNL) is a rare, but distinct, entity within myeloproliferative neoplasms, characterized by splenomegaly, sustained mature neutrophilia, and absence of the Philadelphia chromosome. In 2013, oncogenic mutations in colony stimulation factor 3 receptor (CSF3R) were identified in a majority of patients with CNL and it was demonstrated that their downstream signaling was sensitive to known kinase inhibitors. This discovery was then validated with the demonstration of 100% CSF3R mutational frequency (predominately CSF3R-T618I) in strictly CNL as defined by the World Health Organization (WHO). In September 2012, a 67-year-old Chinese man was admitted to the First Central Clinical College of Tianjin Medical University (Tianjin, China) and presented as a case who had fulfilled the WHO diagnostic criteria for CNL with a oncogenic mutation in CSF3R-T618I and also an unreported novel mutation site of CSF3R-H54A Thus, we sought to determine if CSF3R-FL, CSF3R-T618I, CSF3R-H54A mutations have some significance on the molecular pathogenesis of CNL. Methods: In this study, three main experiments were used including plasmid construction, lentiviral packaging system, and Mouse Colony-Forming Unit Assays Using MethoCult™. Results: The establishment of these three experiments was completed successfully. We confirmed the transformation capacity of the CSF3R mutations, especially that CSF3R-T618I was higher than CSF3R-FL Conclusion: This result demonstrates that T618I mutation of CSF3R conferred the clonal advantage of CNL leukemia cells.
Comparative Study of Suicide Methods During 1991-2008 in the Ulaanbaatar Community
Authors: Davaasuren Oyunsuren , Zuunnast Khishigsuren , Naidansuren Tuya
Published: November 2023

Objectives: The purpose of our study is to compare the prevalence and the methods used for fatal suicidal behaviors among the population in Ulaanbaatar, Mongolia. Methods: A descriptive and retrospective study was conducted based on all data related to fatal suicidal behaviors among the Ulaanbaatar community through reanalysis of secondary data from two epidemiological studies. Results: Totally, 3498 fatal suicide cases were recorded among the Ulaanbaatar population in 1991-2008. Most of the fatal suicide cases (85.1%) were males and 71.6% of the total respondents strangled oneself for fatal suicide, making strangulation the most commonly-used suicide method. Fatal suicide cases due to acute alcohol intoxication (4.6%) or committing suicide while being drunk (3.0%) were recorded in 1991-2002, but were not recorded during 2003-2008. For the fatal suicide cases, being strangled from the ger toono accounted for 12.9% of the total strangulation cases and it was a specific characteristic for Mongolia. More 18-34 year-olds were registered as fatal suicide casesthan other age groups (40.7% in 1991-2002 and 53.3% in 2003-2008). Condusion:ln Ulaanbaatar, the group most likely to complete suicide was 18-34 year-old males, therefore intervention strategies to reduce suicide in Mongolia should focus particularly on this group.
Understanding the Thymic Microenvironment: the Cellular and Molecular Basis of T Cell Development
Authors: Nitta Takeshi
Published: November 2023

Objectives: The thymus is a primary lymphoid organ that provides specialized microenvironment for T cell development. A variety of thymic stromal cells form the thymic tissue architecture and critically regulate the development and repertoire selection of T cells. Methods: We reviewed historical and recent studies on thymic stromal cells, especially focusing on the well-characterized functions of thymic epithelial cells (TECs) and the significance of as yet less characterized non-TEC thymic stromal cells and hematopoietic antigen-presenting cells in the regulation of T cell development. Results: Cortical TECs (cTECs) induce positive selection of diverse and functional T cells, while medullary TECs (mTECs) establish T cell tolerance via the negative selection of auto-reactive T cells and their conversion into regulatory T cells. These modes of T cell tolerance induction are also mediated by hematopoietic antigen-presenting cells such as dendritic cells and thymic B cells. Thymic mesenchymal cells, a prominent component of non-TEC thymic stromal cells, support the development and maintenance of TECs and thereby T cell production. Conclusion: Understanding the cellular and molecular basis for thymic stromal subsets will provide invaluable information toward in vivo reconstitution of the thymic microenvironment for future therapeutic applications.
Electronic Health Record can Better Support Primary Care in Mongolia
Authors: Chae Young Moon , Davaasuren Munkhzul
Published: November 2023

No abstract  in English
Higher Leptin Level among Mongolians with Metabolic Syndrome as a Predictor of Cardiovascular Risk
Authors: Dagdan Batnaran , Chuluun-Erdene Ariunbold , Sengeragchaa Orgil , Sanjmyatav Purevjal , Janlav Munkhhtsetseg
Published: November 2023

Objectives: The focus of our research was to determine and identify the cutoff level of leptin in Mongolian adults with metabolic syndrome (MS). Methods: This observed case-controlled study was performed with 259 adults (mean age 40.35±10.75; range 18-71 years old). A questionnaire and anthropological measurements were used for obtaining data. Fasting blood sugar, serum triglyceride, total cholesterol, HDL, adiponectin, leptin, and insulin were measured in fasting blood together with LDL and HOMA-IR calculations. Sensitivity and specificity were estimated for each leptin measurement, using MS as the outcome. These values were used to construct a receiver operating characteristic (ROC) curve. Results: Average leptin levels of the group with MS were 10.97±11.32 ng/ml and 23.86±11.32 ng/ml in males and females, respectively. The average leptin level of participants with MS was 17.23±1.59 ng/ml, which was significantly higher than the control group by 10.80±1.58. The MS exposed group had a much higher level of leptin than the control group (p<0.001). Leptin was the predictor of MS in both sexes (AUC-0.839, p<0.0001 for men and AUC-0.737, p<0.0001 for women). Conclusion: Leptin levels in the MS exposed group were higher than in the control group. Leptin may be a useful biomarker of cardiovascular risk in Mongolian adults.
Serum Levels of Mannose-Binding Lectin in Atopic and Healthy Mongolian Adults
Authors: Narantsogt Giimaa , Mundur Burnee , Enkhbaatar Zanabazar , Dogsom Oyungerel , Enkhbayar Saruul , Gunregjav Nyamaa , Tsogjargal Urantsetseg , Dashdendev Narmandakh , Agvaandaram Gurbadam , Im Kyung-il , Dorjsuren Temuulen
Published: November 2023

Objectives: Mannose-binding lectin (MBL) is a vital protein of an innate immune system synthesized by the liver. The serum level of MBL is associated with an increased susceptibility to infection with a high risk of allergic and autoimmune diseases. The aim of this study was to determine the profile of serum levels of MBL in atopic and healthy Mongolian subjects. Methods: Serum samples were collected from 219 healthy Mongolian adult blood donors and 216 atopic subjects. We analyzed the MBL level in each serum by using the double-antibody sandwich ELISA method. Results: The mean serum level of MBL was 3088.28 ± 669.8 ng/ ml in atopic subjects and 2165.07 ± 708.5 ng/ml in healthy groups. In males, the MBL mean serum level of atopic subjects was 3012.8 ± 783.16 ng/ml and 2073.33 ± 678.26 ng/ml in the healthy group of males. The MBL mean serum level of female atopic subjects was 3138.22 ± 580.6 ng/ml and 2263.61 ± 733.1 ng/ml in the healthy group of females. Low association and significant differences were observed between MBL levels of atopic and healthy subjects. Conclusion: The serum level of MBL in atopic subjects was comparatively higher than in subjects of the healthy group. Significant differences were observed between mean levels of MBL between the different age groups.
Research Results on Survival Rate for Postoperative Colon Cancer Surgery
Authors: Rentsenbalbar Ganbaatar , Munkhjargal Chinzorig , Nachin Baasanjav
Published: November 2023

Objective: Although the incidence of colorectal cancer is relatively low in Mongolia, the postoperative survival rate has not been fully studied. Thus, we have aimed in the present study to analyze the survival rate after surgical treatment of colorectal cancer. Methods: We studied the patient history of all patients who underwent surgery in the General Surgery Department, National Cancer Center of Mongolia from January 2013 to December 2015 and evaluated the results. Results: The average survival rate of all patients was 42 months or 95 %. In patients with colorectal cancer, the 5-year survival rate after surgery was 59.3 %. By stages, the percentage of patients diagnosed in stage I was 100 %, in stage II 75 %, in stage III 64.4 %, and in stage IV 12.5 %, and the survival rate varied from stage to stage. It was also found that early diagnosis was directly related to survival rate (p = 0.000). Furthermore, the outcome of postoperative chemotherapy had a direct effect on the postoperative survival rate (p = 0.000). The average survival rate is 1280 days 1172.7 - 1389.06 (95 % conf. Interval), 42 months 38.5 - 45.6 (95 % conf. Interval), 3.5 years 3.2 - 3.8 (95 % conf. Interval), which was relatively high compared to other cases of cancer. In addition, the survival time is statistically related to the outcome of surgery and postoperative treatment (p = 0.000). Conclusion: The results of our study show that viability decreases statistically in later stages of cancer manifestation.
Mid-Term Results of High Tibial Osteotomy Regarding From Grades of Knee Osteoarthritis
Authors: Boldbayar Tuvshinjargal , Sosor Baatarjav , Maidar Otgonbayar , Orgoi Sergelen , Dagvasumberel Munkhbaatar
Published: November 2023

Objectives: The number of high tibial osteotomy (HTO) has significantly increased in Mongolia, however, researchers are still debating about the impact of severity of knee osteoarthritis on the outcome of high tibial osteotomy. The purpose of our study is to report the mid-term results of HTO for knee osteoarthritis according to the Kellgren Lawrence classification. Methods: A total of 100 patients who underwent high tibial osteotomy for knee osteoarthritis from October 2019 to June 2020 at the Joint Center of the First Central Hospital of Mongolia participated in this study. Outcome evaluation of the participants was accomplished at baseline, at 2 months, 6 months, 8 months and 18 months post-operatively. Results: Lateral closing wedge HTO was performed in 54.2 % of patients who had 1st grade deformity and 55.9 % of patients who had 2nd grade deformity. On the other hand, medial opening wedge HTO was performed in 3rd grade patients compared to other grades. WBL was 11.43 ± 8.22 at preoperative, and increased to 56.31 ± 4.52 after 12 months of the surgery in 3rd grade. The total WBL was improved from 20.54 ± 12.57 to 57.24 ± 3.69 after two months of surgery and 57.89 ± 4.17 after 12 months. Conclusion: Our study showed that the severity of knee osteoarthritis had impact on outcome of high tibial osteotomy.
Clinical Dentistry Daily Reference Guide
Authors: Ser-Od Tungalag
Published: November 2023

No abstract in English
Comparative Study of Endoscopic and Conventional Septoturbinoplasty in Patients with Nasal Airway Obstruction
Authors: Purev Munkhbaatar , Hoon Han Yong , Gombogaram Tsogtjargal , Nansalmaa Erdenekhuu , Lkhagvasuren Tamir , Logshir Nyamdulam , Altangerel Tsend-Ayush , Palamdorj Ganchimeg
Published: November 2023

Objectives: The goal of our study was to perform endoscopic septoplasty with or without turbinate reduction and also to determine its postoperative subjective and objective improvements. Methods: This was a hospital-based pre and post clinical trial study of 63 patients with nasal septal deviation treated with endoscopic and conventional septoplasty with or without turbinoplasty from 2013 to 2016. Nasal airway patency was recorded before and 2.7 months after surgical treatment using a visual analogue scale (VAS), Glatzel mirror test and bilateral peak nasal inspiratory flow (PNIF) measure. Results: Endoscopic (27 patients) and conventional septoturbinoplasty (36 patients) was performed on 63 patients (40 males; 23 females) with a mean age of 35 years. The results showed a significant improvement of nasal passage condition in scales of VAS, Glatzel mirror test, and bilateral PNIF values after surgery in both groups. In both surgical techniques septoplasty with turbinate reduction showed better improvement in VAS and bilateral PNIF scores than septoplasty alone. Conclusion: The application of endoscopic technology has an advantage of precise visualization and is a valuable tool especially when it is used for educational reasons. Subjective and objective improvements were confirmed equally in both endoscopic and conventional groups.
Child Health: A Population Perspective
Authors: Bold Nomin , Byambaa Nyamzaya , Atarsaikhan Khulan , Sainjargal Suvd , Bayarbat Bayarmaa , Tseyenregzen Murun , Mandakh Undram
Published: November 2023

No abstract in English
Minimal Stimulation Using Gonadotropin Combined with Clomiphene Citrate or Letrozole for Intrauterine Insemination
Authors: Dagvadorj Bolormaa , Erdenebileg Nasantogtokh , Davaasuren Enkhmaa , Shirchinjav Altantuya , Dagvadorj Otgontsetseg , Jamsranjav Enkhtsetseg
Published: November 2023

Objective: In this study we aimed to evaluate the administration efficiency of first-line drugs such as clomiphene citrate (CC), letrozole (L), and the gonadotropin follicle stimulating hormone (FSH) to be used in ovulation induction for intra uterine induction (IUI) in Mongolian patients. Methods: In this prospective single center study we recruited 158 infertile women with polycystic ovarian syndrome (PCOS). Results: In the FSH group, 15 patients (31.2 %) had mycoplasma. On the other hand, the group CC and the L group had a significantly higher number of pregnancies compared than the FSH group. Moreover, there was a trend for an increasing volume of menstruation in the CC group. 38.6 % having a medium volume of menstruation, while 59.6 % had a big volume of menstruation. Stimulation characteristics of patients shows that estradiol on started day (SE2) was significantly higher in the FSH group (768.91 ± 575.64), while it was 523.66 ± 435.84 and 419.36 ± 326.30 in the CC and the L groups, respectively. Conclusions: A minimal stimulation protocol using FSH, CC and L separately was done in Mongolian women with polycystic ovarian syndrome (PCOS). Clinical pregnancy rates were 1.46 ± 0.50 in the FSH group, 1.35 ± 0.48 in CC group, and 1.38 ± 0.49 in L group.
Efficacy of Intravitreal Bevacizumab in Neovascular Age-Related Macular Degeneration
Authors: Altankhuyag Ariunzaya , Tumendemberel Zoljargal , Ganbold Chimedlkhamsuren , Jamianjav Baasankhuu , Jav Sarantuya , Davaatseren Uranchimeg
Published: November 2023

Objective: To study the effect of cataract surgery with intravitreal bevacizumab therapy on visual and anatomical outcomes in patients with neovascular age-related macular degeneration (AMD) in Mongolian patients. Methods: A retrospective analysis of 72 eyes of 36 patients with neovascular AMD evaluated intravitreal bevacizumab (1or2.5 mg) injections. Retreatment was performed following an optical coherence tomography (OCT)-based regimen. Ophthalmic examination included best-corrected visual acuity (BCVA), dilated fundus examination, and OCT image analysis. Results: A total of 11 patients received cataract surgery. We could not observe statistical significance between the two groups. The BCVA of the right eye of patients having cataract surgery improved by 0.21 ± 0.29, while the corresponding value for patients without surgery was 0.32 ± 0.32. The mean central retinal thickness (CRT) of patients with refraction was decreased from 264.4 ± 82.32 μm at baseline to 244.55 ± 52.59 μm for the right eye, while it was 275.4 ± 96.4 μm at baseline to 276.36 ± 68.22 μm for the left eye. Conclusion: Cataract surgery with intravitreal bevacizumab therapy in eyes with neovascular AMD in aged patients was performed.
Laser in Situ Keratomileusis for Moderate to High Myopia in Mongolians
Authors: Baasanjav Tsetsegjargal , Davaatseren Uranchimeg , Dambadarjaa Davaalkham , Jamyanjav Baasankhuu
Published: November 2023

Objectives: To compare the pre and post-operative outcomes of Mongolian patients who had LASIK surgery. Methods: We conducted hospital based prospective study. A total of 176 consecutive patients who underwent conventional LASIK were examined for the correction of myopia. Study participants were followed for 5 years after surgery.Results: The mean age was 29.89 ± 6.42 years. 145 patients were female and 31 were male. The mean UCVA was 0.10 ± 0.09 Decimal and the mean BCVA was 0.81 ± 0.16 Decimal. Preoperative analysis showed that UCVA and BCVA were significantly different in mild, moderate, and high myopia groups. Especially, patients with mild myopia had higher acuity compared to other groups (0.21 ± 0.13 and 0.86 ± 0.12, respectively). Moreover, the manifest spherical equivalent the of mild myopia group also had significantly lower compared to the other two groups (-1.73 ± 1.17).Conclusions: Our results support the view that preoperative clinical examination is an extremely important part of the LASIK procedure to improve refractive predictability.
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF BERBASIS WEBSITE SEBAGAI PENUNJANG PEMBELAJARAN ADMINISTRASI PAJAK KOMPETENSI PPH KELAS XI AKUNTANSI
Authors: Afifah Nur , Listiadi Agung
Published: November 2023

Ketersediaan media pembelajaran dalam kegiatan belajar harus bisa memberikan kemudahan bagi peserta didik dalam pembelajaran. Penelitian pengembangan yang dilakukan menggunakan model pengembangan ADDIE yang dicetuskan oleh Dick & Carry. Data kualitatif dan kuantitatif akan diperoleh dalam penelitiani ini melalui instrument pengumpulan data berupa kuisioner. Kemudian data  yang diperoleh akan diinterprestasikan berdasarkang perhitungan dengan skala likert. Media pembelajaran interaktif berbasis website merupakan produk akhir dari penelitian ini. Sebelum diuji coba, media tersebut menjalani proses telaah dan validasi oleh para ahli media dan materi sebelum diuji cobakan. Sebanyak 20 peserta didik kelas XI Akuntansi melakukan uji coba media. Temuan penelitian ini mengungkapkan bahwa hasil validasi ahli media mendapatkan skor sebesar 98%, ahli materi 94%, dan angket respon peserta didik 98%. Dengan demikian, dapat disimpulkan bahwa media pembelajaran interaktif berbasis website menggunakan Articulate Storyline 3 sangat layak digunakan sebagai penunjang pembelajaran
PENERAPAN MODEL PEMBELAJARAN CREATIVE PROBLEM SOLVING BERBANTUKAN MEDIA ARTICULATE STORYLINE UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR ANALITIS
Authors: Karlina Lilis , Afriza Edi Fitriana , Srigustini Astri
Published: November 2023

Penelitian ini dilakukan dengan dilatarbelakangi oleh adanya permasalahan berupa rendahnya tingkat kemampuan berpikir analitis peserta didik kelas X IPS di SMA Negeri 4 Kota Tasikmalaya. Tujuan dari penelitian ini yaitu untuk meningkatkan kemampuan berpikir analitis peserta didik kelas X IPS pada mata pelajaran ekonomi melalui penerapan model pembelajaran Creative Problem Solving (CPS) dengan bantuan media Articulate Storyline. Penelitian ini dirancang dengan menggunakan desain kuasi eksperimen bentuk Nonequivalent control group design. Hasil penelitian menunjukan bahwa nilai rata-rata N-Gain kelas eksperimen lebih tinggi yaitu sebesar 0,73 dibandingkan kelas kontrol yang hanya sebesar 0,64. Sehingga dapat disimpulkan bahwa model pembelajaran Creative Problem Solving (CPS) dengan bantuan media Articulate Storyline memberikan efektivitas yang lebih tinggi dalam meningkatkan kemampuan berpikir analitis peserta didik. Implikasi dari penelitian ini yaitu peserta didik mampu untuk menganalisis dan menyelesaikan permasalahan yang diberikan secara kreatif dengan langkah-langkah yang sistematis. Adapun keterbatasan dari penelitian ini yaitu terkait waktu penelitian yang cukup singkat