bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of Molecularly Imprinted Membrane Glucose for Selective Membrane Transport
Authors: Djunaidi Muhammad Cholid , Utari Henita Saulia , Khabibi Khabibi
Published: September 2023

Molecularly Imprinted Membrane (MIM) was synthesized using polyeugenoxy acetic acid as the functional polymer, polyethylene glycol as the crosslinker agent, and polysulfone as a base membrane which was applied as a selective glucose membrane transport, and the immersion time expected to determine the transport capability of the membrane. This study aimed to determine the selectivity and transport properties of the MIM and NIM membranes. NIM was used as a control for MIM to research the selectivity test. In comparison, MIM has a template, while NIM is without a template. In this study, eugenol derivatives were synthesized through a polymerization reaction using a BF3-diethylether catalyst polymerized for 16 hours to produce polyeugenoxy acetic acid (PA). The PA was contacted with 7500 ppm glucose. PA-glucose produced an imprinted membrane, while PA produced a non-imprinted membrane. The membrane thickness was measured with a micrometer, resulting in a measurement range of 0.08–0.10 mm. The best transport result was achieved at the membrane passage of 24 hours of immersion time because the effect of membrane immersion time can increase the porosity, hydrophilicity, and membrane’s transport ability. Transport with MIM membrane shows better and more selective results than NIM. This confirms the existence of a glucose template on the MIM membrane, which causes the MIM membrane to recognize glucose and transport glucose better than fructose. This study’s advantages include learning how immersion time affects membrane production and determining how well MIM and NIM membranes transport and select glucose and fructose. Furthermore, membrane characterizations were done using FTIR to identify functional groups, SEM-EDX to analyze the shape of the membrane, and a UV-Vis spectrophotometer to analyze the membrane’s selectivity and transport capabilities.
The Rise and Fall of the Eurasian Regionalism
Authors: Libman Alexander
Published: September 2023

The essay traces the evolution of the Eurasian regionalism over the last three decades. It focuses on the inherent contradictions between the centripetal market forces and the geopolitical clashes affecting the economic integration perspectives. In Eurasia, economic integration has been repeatedly reinterpreted in terms of geopolitical power; at the same time, economic interaction emerged across the politically motivated boundaries.
Utilizing microresistivity image logs to recognize conglomeratic channel architectural elements of Baikouquan Formation in slope of Mahu Sag
Authors: Pang Zhichao , Yuan Rui , Yuan Bo , Ji Dongsheng , Tang Xueying , Zhao Kang , Zhang Xianghui
Published: September 2023

Geological outcrop is usually the first-hand evidence to cognize the probable geometry, lateral extent, and other properties of conglomeratic channels. If there is no exposure of formation, however, it is hard to recognize elaborate architectural elements just based on poor coverage cores and low-resolution conventional logs vertically. In order to understand vertical distributions of conglomeratic channel architectural elements in the Lower Triassic Baikouquan Formation in southern slope of Mahu Sag, ultrahigh-resolution microresistivity image logs are used to recognize elements under the concept of conglomeratic channel architectures in this article. The microresistivity images were calibrated with cores in different grain-sizes and sedimentary structures. According to microresistivity image fabric, subaerial channel-fills consisted of granules to cobbles; subaqueous channel-fills were composed of well-sorted sandstones to granules. Subaerial channel-margins comprised sandstones to pebbles; subaqueous channel-margins were granules and sandstones. Bypass drapes, deposited from the tail of bypassing flows, were commonly eroded by overlying channel-fills. Convergent drapes, accumulated on top surfaces of channel-margins, preserved well without reworking. Overbank drapes, formed outside the channel, were thick-bedded. Combined with dipmeter pattern of microresistivity image log, six channel story sets were recognized depending on abrupt changes in dip azimuths. In each channel story set, per unit thickness of mud drapes ranged from 0.1 to 0.6 m. Mud drapes in channel story set 1 could be correlated horizontally. In channel story sets 3, 4, and 5, thickness of mud drapes ranged from 0.05 to 2.59 m and averaged at 0.59 m, and channel conglomerates and mud drapes alternated frequently. These understandings would provide important insights on the production potential of petroleum.
Petrine Failings and Broken Pentangles:

Sir Gawain and the Green Knight
’s Chivalric Felix Culpa
Authors: McKee Arielle
Published: September 2023

In Sir Gawain and the Green Knight, supernatural testers disrupt both Arthur’s court and the interlocked perfections of the Pentangle, weighing Gawain and finding him wanting. Gawain’s failure, moreover, foregrounds the human need for grace and forgiveness, demonstrating both the impossibility of human perfection and the humanity of imperfections redeemed. This essay explores the semi-typological relationship between Gawain and St Peter, arguing that the likenesses between the Arthurian knight and Christ’s disciple effectively reinforce the poem’s message that failings are inevitable in a post-lapsarian world, but that those errors can yet be mercifully and graciously redeemed. Gawain’s fairy-wrought ‘fall’ from excellence is, it turns out, a happy one – a chivalric felix culpa that makes room for the forgiveness and recovery of knightly failings.
The long-crowing chickens in Indonesia: A review
Authors: Asmara Indrawati Y. , Hilmia Nena , Garnida Dani
Published: September 2023

All birds produce vocalizations as a form of tcommunication with other individuals. Different from songbirds, crowing is a singing vocalization produced by chickens that cannot be learned through imitation. Some genes are assumed to be responsible for this activity. The long-crowing chickens have a melodious and long sound, so they are categorized as singing chickens. They are part of the biodiversity in Indonesia, which has high economic and socio-cultural value. Reviews about long-crowing chickens, especially in Indonesia, are still very rare. This article aims to identify the uniqueness and the existence of long-crowing chickens, together with the conservation efforts needed to manage them. Information was collected from journal articles and other relevant documents. There are four local chickens in Indonesia classified as long-crowing chickens. They are developed in different areas of the community with different socio-cultural characteristics. The fundamental differences among the breeds that can be quantified are in crowing duration and the number of syllables. The government has acknowledged that long-crowing chickens are important genetic resources; however, the association and individual keepers or enthusiasts are vital actors in conservation efforts. The information about long-crowing chickens in Indonesia is incomplete. The research activities that need to be conducted include exploring the population number and distribution, as well as documentation of the local knowledge of chicken breeders and enthusiasts.
The improvement of horticultural villages sustainability in Central Java Province, Indonesia
Authors: Sutrisno Joko , Haryanto Eddy Tri , Harsono Puji , Pujiasmanto Bambang , Nugroho Reismaya Wanamertan
Published: September 2023

The potential for vegetables in Indonesia is enormous. However, activities both upstream and downstream are still not well developed so that Indonesia is still importing horticulture to meet domestic needs. Because the potential for horticulture has not been maximized, the Ministry of Agriculture is holding a Horticultural Village program, one of which is in Central Java. The Horticultural Village Program that has been running requires a strategy to increase its sustainability. This research was conducted in Central Java to determine strategies to improve the sustainability of the horticultural village program. The method used in this study is multidimensional scaling (MDS) with the rapid appraisal for horticultural village (RAP-HORVI) technique or RAP-HORVIs. This research method will produce an index value that will determine the sustainability status of all dimensions used, namely, input, process, output, and outcome. The result of this analysis is that the Horticultural Village in Central Java is in a quite sustainable status. The results of this MDS show that 12 sensitive attributes can be used as strategies in increasing the value and sustainability status of Horticultural Villages in Central Java, namely, business management training, availability of production tools and materials, suitability of production input facilities, technical training, availability of capital, optimizing the use of infrastructure assistance, checking on farmers/micro, small, and medium enterprises beneficiaries of SK CPCL, intensive assistance by trainers, increasing planting area, increasing the number and variety of plant types, planning the area of land ready for planting, and increasing business capital.
Public Mental Health von Kindern und Jugendlichen – wie ist die Studienlage?
Authors: Zöllner Fionna , Devine Janine , Kaman Anne , Reiß Franziska , Ravens-Sieberer Ulrike
Published: September 2023

Die psychische Gesundheit von Kindern und Jugendlichen ist ein wichtiger Teilbereich von Public Health. Epidemiologische Studien zeigen, dass etwa ein Fünftel der Kinder und Jugendlichen psychische Auffälligkeiten aufweisen und sich die Prävalenz während der COVID-19-Pandemie noch deutlich erhöht hat. Akteure aus Wissenschaft, Gesundheitswesen und Politik sind aufgefordert eng zusammenzuarbeiten, um allen Kindern und Jugendlichen ein gesundes Aufwachsen zu ermöglichen.
Die Förderung psychischer Gesundheit in Lebenswelten von Kindern und Jugendlichen
Authors: Müller Michéle , Koschig Maria , Riedel-Heller Steffi , Conrad Ines
Published: September 2023

Der Leipziger Verein Irrsinnig Menschlich e.V. etabliert seit über 20 Jahren Präventionsprogramme zur psychischen Gesundheit in verschiedenen Lebenswelten von Kindern und Jugendlichen, welche teilweise als Beispiele guter Praxis angesehen werden. Sowohl im Bildungs- als auch im Freizeitsektor werden Akteure für das Thema sensibilisiert und gesundheitsförderliche Bedingungen geschaffen. Durch die Begleitforschung der Programme können Bedarfe, Effekte und Verbesserungsmöglichkeiten ermittelt werden.
Stärkung von Elternkompetenz als Schlüsselfaktor für die psychische Gesundheit von Kindern und Jugendlichen: Eine Public Health-Aufgabe
Authors: Dirscherl Ronja
Published: September 2023

Eltern haben großen Einfluss auf die psychische Gesundheit von Kindern und Jugendlichen. Elternkompetenz kann durch evidenzbasierte Interventionen gestärkt werden. Die Weltgesundheitsorganisation empfiehlt daher global die Bereitstellung evidenzbasierter Elternprogramme. Eine nationale Strategie im Bereich Mental Public Health sollte diesen Faktor adressieren und dabei Erkenntnisse aus der Implementierungsforschung sowie Besonderheiten der deutschen Versorgungsstrukturen berücksichtigen.
Technologies and standards in ceramic production of middle–late Trypillya culture
Authors: Starkova Elena
Published: September 2023

In recent decades, many studies have been carried out on the technology of ceramics of the Trypillya-Cucuteni culture. The presented article gives a summary of much of the information amassed. All stages of the Trypillya ceramic production have been considered: the preparation of the clay mass, the methods of modelling, the connection of structural parts, and decoration. Manufacturing standards for vessels that formed ceramic assemblages of different chronological stages of Trypillya culture are identified. Particular attention is paid to the study of engobe and the composition of pigments in the paint layer.
Erweiterte Nukleare Abschreckung – zur Glaubwürdigkeit der NATO-Strategie im Lichte der russischen Bedrohung
Authors: Brauß Heinrich
Published: September 2023

Kurzfassung

Russlands Angriffskrieg, Präsident Putins strategische Ziele und Moskaus nukleare Drohungen gefährden Europas Sicherheit. Die NATO antwortet mit einer neuen Strategie, der signifikanten Stärkung ihrer Verteidigungsfähigkeit und der Aufnahme Finnlands und Schwedens. Ihr nukleares Dispositiv bleibt gleich. Seine Rolle und Wirkungsweise basieren auf den Prinzipien der Flexible Response von 1967, die auch der erweiterten nuklearen Abschreckung der USA zugrunde liegen. Diese verbindet Europas Sicherheit sichtbar mit der Sicherheit Amerikas. Nukleare Teilhabe der Europäer verlangt Kenntnis, Kompetenz und Mitverantwortung. Europäische nukleare Abschreckung durch Frankreich und Großbritannien kann Amerikas erweiterte Abschreckung nicht ersetzen. Aber die Option, einen Krieg zu beenden mit einem selektiven Einsatz von Atombomben, gelenkt von europäischen Kampfflugzeugen (F-35) gegen Ziele in Russland, sollte ergänzt werden – durch zielgenaue, landgestützte Flugkörper und großflächigen Ausbau der Luftverteidigung in NATO-Europa, um so mehr Flexibilität zu erreichen.
Factores predominantes que influyen en el indicador de rendimiento académico en los universitarios in situ
Authors: Ramírez Lemus Lidia , Rodríguez Rodríguez Carlos Alberto , Barrón-Adame José Miguel , Cuevas Vargas Héctor
Published: September 2023

Esta investigación se desarrolló en una universidad al suroeste de Guanajuato, México. El objetivo fue identificar la influencia de los factores predominantes (socioeconómicos, académicos, familiares y personales) que inciden de manera directa en el rendimiento académico de los universitarios. El método fue cuantitativo de corte transversal-correlacional, con variables no paramétricas. El instrumento que se utilizó comprende 40 ítems, aplicado sistemáticamente a una muestra de 1339 estudiantes. Los resultados fueron significativos con un 95% de confiabilidad. Solo tres de cinco factores fueron aceptados de acuerdo con la prueba Spearman: los personales (0.952), en horas dedicadas al estudio; los académicos (0.790), en becas y maestros preparados; y los familiares (0.803), en la influencia de la familia. Por lo tanto, se confirma que existen correlaciones positivas con el indicador rendimiento académico. En este sentido, la correlación estadística permitió identificar la relación del rendimiento académico entre los factores predominantes mencionados y la vulnerabilidad a la que los universitarios están expuestos.
Training Wheelchair Tennis Players: A Strength and Conditioning Approach
Authors: Roetert E. Paul , Allen Jason , Davies Karl , Harnett Jason , Ochi Satoshi
Published: September 2023

The sport of wheelchair tennis has experienced significant growth in the United States, both at the grassroots and professional arenas. Much of this growth is due to the United States Tennis Association (USTA) taking control over the Paralympic side of the sport in 1998, followed by full integration of wheelchair tennis into the various business units of the organization in 2021. This led to the availability of greater resources benefiting USTA Player Development and high performance athletes. One of the most apparent benefits is using strength and conditioning USTA as the national professionals to improve athletic performance and decrease injury prevalence. Wheelchair tennis coaches and strength and conditioning professionals have collaborated to design innovative adaptations and accommodations. Therefore, the aim of this paper is to highlight the significant business and organizational progress made by the USTA as the National Governing Body for the sport of tennis, as well as to address practical strategies to develop and implement wheelchair players' specific strength and conditioning needs.
Visual and Rapid Detection of Escherichia coli O157:H7 in Stool Samples by FTA Card-based Loop-mediated Isothermal Amplification
Authors: Chen Fumin , Wang Junyu , Li Weiguang , Zhang Yuqian , Xiu Leshan , Hu Qinqin , Ruan Zhengshang , Chen Ping , Yin Kun
Published: September 2023

Objective:

Escherichia coli O157:H7 (E. coli O157:H7) can induce severe diseases in animals and humans that result in significant public health problems. Therefore, the development of rapid and visual detection methods to diagnose E. coli O157:H7 infections and monitor its prevalence is critical for the prevention and control purposes.

Methods:

A colorimetric loop-mediated isothermal amplification (LAMP) assay was utilized to detect E. coli O157:H7. A DNA extraction kit and Flinders Technology Associates (FTA) cards were used to extract nucleic acid in conjunction with colorimetric LAMP detection.

Results:

The method developed effectively distinguished E. coli O157:H7 from other pathogens with a detection limit of 25 CFU/mL in spiked stool samples. In addition, the nucleic acid of these samples was easily extracted and transported with an FTA card at room temperature. The entire detection process was completed within 35 min using simple constant-temperature equipment.

Conclusion:

The colorimetric LAMP method with FTA card-based nucleic acid purification was shown to rapidly detect E. coli O157:H7 with sensitivity and specificity. This visual method is expected to be widely used to control E. coli O157:H7 infections, particularly in resource-limited settings.
Cardiomyocyte orientation recovery at micrometer scale reveals long‐axis fiber continuum in heart walls
Authors: Dileep Drisya , Syed Tabish A , Sloan Tyler FW , Dhandapany Perundurai S , Siddiqi Kaleem , Sirajuddin Minhajuddin
Published: September 2023

Coordinated cardiomyocyte contraction drives the mammalian heart to beat and circulate blood. No consensus model of cardiomyocyte geometrical arrangement exists, due to the limited spatial resolution of whole heart imaging methods and the piecemeal nature of studies based on histological sections. By combining microscopy and computer vision, we produced the first‐ever three‐dimensional cardiomyocyte orientation reconstruction across mouse ventricular walls at the micrometer scale, representing a gain of three orders of magnitude in spatial resolution. We recovered a cardiomyocyte arrangement aligned to the long‐axis direction of the outer ventricular walls. This cellular network lies in a thin shell and forms a continuum with longitudinally arranged cardiomyocytes in the inner walls, with a complex geometry at the apex. Our reconstruction methods can be applied at fine spatial scales to further understanding of heart wall electrical function and mechanics, and set the stage for the study of micron‐scale fiber remodeling in heart disease.
The obesity‐linked human lncRNA AATBC stimulates mitochondrial function in adipocytes
Authors: Giroud Maude , Kotschi Stefan , Kwon Yun , Le Thuc Ophélia , Hoffmann Anne , Gil‐Lozano Manuel , Karbiener Michael , Higareda‐Almaraz Juan Carlos , Khani Sajjad , Tews Daniel , Fischer‐Posovszky Pamela , Sun Wenfei , Dong Hua , Ghosh Adhideb , Wolfrum Christian , Wabitsch Martin , Virtanen Kirsi A , Blüher Matthias , Nielsen Søren , Zeigerer Anja , García‐Cáceres Cristina , Scheideler Marcel , Herzig Stephan , Bartelt Alexander
Published: September 2023

Adipocytes are critical regulators of metabolism and energy balance. While white adipocyte dysfunction is a hallmark of obesity‐associated disorders, thermogenic adipocytes are linked to cardiometabolic health. As adipocytes dynamically adapt to environmental cues by functionally switching between white and thermogenic phenotypes, a molecular understanding of this plasticity could help improving metabolism. Here, we show that the lncRNA Apoptosis associated transcript in bladder cancer (AATBC) is a human‐specific regulator of adipocyte plasticity. Comparing transcriptional profiles of human adipose tissues and cultured adipocytes we discovered that AATBC was enriched in thermogenic conditions. Using primary and immortalized human adipocytes we found that AATBC enhanced the thermogenic phenotype, which was linked to increased respiration and a more fragmented mitochondrial network. Expression of AATBC in adipose tissue of mice led to lower plasma leptin levels. Interestingly, this association was also present in human subjects, as AATBC in adipose tissue was inversely correlated with plasma leptin levels, BMI, and other measures of metabolic health. In conclusion, AATBC is a novel obesity‐linked regulator of adipocyte plasticity and mitochondrial function in humans.
Pejzaże umierania i żałoby w polskiej literaturze ostatnich dekad
Authors:   Wydział Polonistyki, Uniwersytet Jagielloński, Szewczyk Joanna
Published: September 2023

This article concerns the representations of loss and mourning in the recent Polish literature from the perspective of spacial turn. The author analyzes three literary works: Zapiski z nocnych dyżurów [Notes from night duty] by Jacek Baczak, Ostatnie historie [Recent stories] by Olga Tokarczuk and Sorge by Aleksandra Zielińska. The article seeks to demonstrate how such categories as affective heterotopia, emotive topography, affective geography and performativity of place can be useful to study the literary landscapes of dying, mourning and loss. The remarks aim to emphasize spatial, not only temporal, aspect of the experience of death.
Od reminiscencji do antecedencji – Kostomarov, Reymont i Orwell. Rekonesans
Authors:   Wydział Filologiczny, Uniwersytet Łódzki, Hac-Rosiak Barbara
Published: September 2023

Bunt [Revolt] (1924) by Władysław Stanisław Reymont and Animal Farm (1946) by George Orwell display many parallels, probably stemming from the common provenance of the two works, which can be traced to the work Skotskoy bunt [Skotskoj rebellion] (1879) by the Ukrainian writer Nikolai Kostomarov. The works deploy allegory in the construction of dystopian worlds inhabited by animals that rebel against humans. They share a number of motifs, characters and plot patterns, including, most importantly, the desire to overthrow man’s hegemony, which turns against the anthropomorphized heroes. The texts also differ significantly in the circumstances of their creation, the source of imaginative transfer, the symbolism and, finally, the purpose of the animal revolution. The article aims to trace the antecedence and mutual intersection of the works in question.
Povijest građenja Budačkog mosta
Authors: Šulentić Vladimir
Published: September 2023

Premoštenje rijeke Like u Budaku u Gospiću za domicilno stanovništvo se vremenom pokazalo iznimno bitnim, a za graditelje budućeg mosta velikim izazovom. U ovom tekstu kronološki su prikazane radnje i događaji usko vezane za navedeni most kroz razdoblje od sredine 18. stoljeća, pa do današnjih dana s posebnim osvrtom na njegov neizostavni prometni značaj za Gospić i okolicu. Zbog svog smještaja na administrativnom području sela Budak, lokalno stanovništvo prozvalo ga je Budačkim mostom, a kroz povijest je zajedno s ribničkim, bilajskim, kaluđerovačkim i kosinjskim mostovima činio jedan od ključnih prijelaza preko najveće ličke rijeke Like. Prva saznanja o mostu na ovoj lokaciji vezana su za grafičke izvore odnosno vojne karte iz 18. stoljeća, a od druge polovice 19. stoljeća detaljnija proučavanja moguća su zahvaljujući sačuvanoj pisanoj i slikovnoj građi kao i projektnoj dokumentaciji. Važnost mosta je u najvećoj mjeri u tome što se nalazio na najznačajnijoj prometnici za gospićko okružje kojom se Gospić povezivao u smjeru sjevera te smjeru istoka odnosno graničnog područja s Bosnom kod Petrova Sela. Mostom su bosanski trgovci iz bihaćke doline dopremali neophodne živežne namirnice, uglavnom žitarice i kukuruz i spašavali Ličane od gladi. Iz tog razloga nije se smio dopustiti prekid u prometu, pa je sredinom 19. stoljeća izgrađen kvalitetan i čvrst kameni most, koji je Gospićanima pouzdano služio više od osamdeset godina. Da je most imao kvalitetnu osnovu svjedoče i nosivi elementi tj. temelji koji su se u izvornom obliku sačuvali do današnjih dana i kasnije bili glavni oslonac drugim podignutim mostovima.
Odgojno-obrazovni programi u zaštićenim područjima Hrvatske – primjeri iz Like
Authors: Brkić-Vejmelka Jadranka , Paral Mario
Published: September 2023

Premda je u svim zaštićenim područjima Republike Hrvatske primarna zaštita prirode, promiču se i njezine znanstvene, kulturne, estetske te odgojno-obrazovne vrijednosti. U tu svrhu u zaštićenim područjima organiziraju se odgojno-obrazovni programi namijenjeni prvenstveno školskoj populaciji. U radu su analizirani odgojno-obrazovni programi u zaštićenim područjima na prostoru Like: u Nacionalnim parkovima Plitvička jezera i Sjeverni Velebit, u Parku prirode Velebit i Pećinskom parku Grabovača (Značajni krajobraz Risovac-Grabovača). U navedenim zaštićenim područjima, kroz edukativne programe istaknuta je vrijednost prirodnih osobitosti s posebnim naglaskom na pojedine oblike krškog reljefa, poput špilja, a predstavljaju se posjetiteljima kako bi se upoznali sa značenjem i ulogom očuvanja pojedinih ekosustava. Cilj ovog rada je analizirati odgojno-obrazovne programe koji se provode u zaštićenim područjima i time ukazati na njihovu važnost za školsku populaciju, posebice programe prikladne za učenike u razrednoj nastavi. Izdvojene su i aktivnosti koje se organiziraju u vidu škole u prirodi, terenske nastave, radionica u prirodi i slično.
Osnivanje i rad Sabirnog arhivskog centra u Novalji
Authors: Crnković Barbara
Published: September 2023

Sabirni arhivski centar u Novalji započeo je s radom 1. rujna 2009. godine kao sastavnica Državnog arhiva u Zadru. Uz Korčulu, drugi je to sabirni arhivski centar u Republici Hrvatskoj smješten na otoku. Potreba za njegovim osnutkom temeljila se na veličini otoka i broju stvaratelja dokumentarnog i arhivskog gradiva. U članku se opisuje proces njegova osnutka, donose podatci o zgradi u kojoj je smješten, spremišnim kapacitetima, vrsti i strukturi gradiva koje je u njemu pohranjeno te o djelokrugu rada i području nadležnosti.
IGF-1 axis changes with ADT and docetaxel in metastatic prostate cancer
Authors: Ravi Praful , Wang Victoria , Fichorova Raina N , McGregor Bradley , Wei Xiao X , Basaria Shehzad , Sweeney Christopher J
Published: September 2023

Androgen deprivation therapy (ADT) forms the cornerstone of treatment in locally advanced and metastatic prostate cancer (PCa). Since the growth hormone–insulin-like growth factor (GH–IGF-1) axis has been implicated in prostate tumorigenesis, we aimed to evaluate the association between IGF-1 and its binding proteins on outcomes in men with metastatic PCa treated with ADT, with or without docetaxel (D). We analyzed serum samples for IGF-1 and its family proteins from baseline, 6 months post-randomization, and at the time of progression in men enrolled to receive ADT +/− D in the phase 3 CHAARTED trial. The key outcomes were time to the development of castrate-resistant prostate cancer and overall survival (OS). About 560 patients had samples available for analysis. At 6 months, significant increases in IGF-BP1 (mean Δ+27.4%, P = 0.033), IGF-BP3 (mean Δ+10.3%, P < 0.001), and IGF-BP4 (mean Δ+31.1%, P < 0.001) were seen in the ADT + D group, while the ADT group showed an increase in IGF-BP3 (mean Δ+5.5%, P = 0.015). A higher IGF-1:IGF-BP1 ratio at baseline and after 6 months was associated with improved OS in both the ADT (baseline: hazard ratio (HR) = 0.77, P = 0.026; 6 months: HR = 0.83, P = 0.036) and ADT + D groups (baseline: HR = 0.78, P = 0.04; 6 months: HR = 0.81, P = 0.018). Patients with a log10IGF-1:IGF-BP1 ratio >1.3 at baseline had improved OS when meta-analyzed with data from a prior cohort (HR = 0.71). A higher baseline and 6-month IGF-1:IGF-BP1 ratio was associated with better OS. Further exploration of the IGF-1 axis will be important to assess its role as a predictive biomarker and to target this axis in therapeutic trials.
Metformin and its redox-related mechanisms of action in type 2 diabetes
Authors: Vezza Teresa , Luna-Marco Clara , Rovira-Llopis Susana , Víctor Víctor M
Published: September 2023

Type 2 diabetes (T2D) is a long-term metabolic disease characterized by progressive β-cell functional decline and insulin resistance, which increases the risk of cardiovascular complications as well as associated-morbidity and mortality. Evidence suggests a strong relationship between hyperglycaemia, oxidative stress and the development and progression of T2D. Indeed, a hyperglycaemic state can reduce the activity of antioxidant enzymes and increase lipid peroxidation and protein oxidation products, as well as DNA damage. At present, metformin is the recommended first-line glucose-lowering agent in patients with T2D. Despite the vast clinical experience gained over several decades of use, several mechanisms of action of metformin have yet to be fully elucidated. This review provides an overview of the existing literature concerning the complicated interplay between oxidative stress and T2D and the molecular mechanisms underlying the redox-related mechanisms of action of metformin, which include (but are not limited to) interaction with AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms, inhibition of gluconeogenesis and action on leukocyte–endothelium interactions.
Sire modulates developmental kinetics and transcriptome of the bovine embryo
Authors: Lockhart Kelsey Nicole , Drum Jessica N , Balboula Ahmed Z , Spinka Christine M , Spencer Thomas E , Ortega M Sofia
Published: September 2023

In brief

The first week of gestation is a period of major pregnancy loss in cattle, this study reveals that the male plays a key role in regulating embryonic development during this time.

The impact of sire on preimplantation embryonic development in cattle remains poorly understood. This study evaluated differences in embryos produced in vitro from sires with varying capacities to produce blastocysts. Sires classified as high (HP) and low performing (LP) based on their ability to produce embryos were used to better understand how sire regulates embryonic development. By monitoring development, it was determined that the most common arrest stage was the five- to six-cell stage. Embryos (four to six cells) from HP and LP sires were then analyzed for autophagic activity, where embryos for LP sires exhibited increased autophagy than HP-derived embryos. Transcriptome analysis of four-cell embryos found that embryos from LP sires might have issues in sperm mitochondrial clearance, histone retention, and DNA damage, while HP sires had increased expression of genes involved in transcription, chromosome segregation, and cell division. In conclusion, LP sires had an increased proportion of embryos arresting at the five- to six-cell stage, and these embryos had higher rates of cellular stress due to paternal contributions from the spermatozoon.
ВИРОБНИЧА ПРАКТИКА В ЗАКЛАДАХ ОСВІТИ ЯК ВАЖЛИВА СКЛАДОВА ПРОФЕСІЙНОЇ ПІДГОТОВКИ МАЙБУТНІХ МАГІСТРІВ ФІЗИЧНОЇ ТЕРАПІЇ
Authors: КУЗЕНКО ОЛЕКСАНДРА
Published: September 2023

У статті розкриваються основні завдання виробничої практики в закладах освіти для  здобувачів ОС Магістр спеціальності 227.1 «Фізична терапія». Акцентується, що впровадження цього виду практики  в Івано-Франківському національному медичному університеті зумовлюється ефективним функціонуванням  інклюзивної форми навчання в загальноосвітніх закладах  та актуальними потребами сучасного українського суспільства в наданні якісних реабілітаційних послуг  під час широкомасштабних бойових дій. У стандарті вищої освіти зі спеціальності 227 Фізична терапія, ерготерапія галузі знань 22 Охорона здоров’я для другого (магістерського) рівня вищої освіти зазначено, що базами практик можуть бути  як реабілітаційні інституції, відділення, підрозділи в галузі охорони здоров’я, так і заклади соціального захисту, освіти, де створені умови для менеджменту різновікових категорій пацієнтів  з порушеннями функцій, що потребують фізичної терапії, тому проходження практики в загальноосвітніх закладах з інклюзивною формою навчання розглядається автором як одна з дієвих форм розвитку  професійної готовності майбутніх фізичних терапевтів  до роботи з пацієнтами дитячого віку з ООП.
ЦИФРОВІЗАЦІЯ ОСВІТНЬОГО ПРОЦЕСУ В ЗАКЛАДАХ ВИЩОЇ ОСВІТИ В УМОВАХ ВОЄННОГО СТАНУ
Authors: ПАВЛИШ ТЕТЯНА , БАСАРАБ ВОЛОДИМИР , Терещенко Олександр , РОГІВ МАРІЯ
Published: September 2023

Статтю присвячено дослідженню проблем цифрової трансформації освітнього процесу в умовах воєнного часу, можливості використання сучасних інформаційних технологій в умовах обмеженого доступу до ресурсів та інфраструктури. Також розглядається проблема забезпечення якості освіти під час воєнного стану та шляхи її вирішення за допомогою цифрової технології. Обговорюється роль і вплив цифровізації на освітній процес у закладах вищої освіти. Автори окреслюють різні аспекти застосування цифрових технологій, таких як електронні підручники, відеоуроки, відеоконференції та ін. інструменти, які дозволяють підвищити якість та ефективність освіти.

Крім того, розглядається вплив цифровізації на організацію освітнього процесу та взаємодію між викладачами і студентами, застосування цифрових інструментів, що дозволяє студентам більш активно брати участь у процесі навчання, сприяє взаємодії між викладачами і студентами, а також забезпечує більш ефективну та зручну форму навчання.

Автори звертають увагу на проблеми, які можуть виникнути під час упровадження цифрових технологій у навчальний процес. Аналізуються такі проблеми, як відсутність доступу до необхідної інфраструктури та технічних засобів, недостатнє навчання викладачів і студентів користування цифровими інструментами, а також стосовно збереження і захисту даних. Наголошено, що цифрові технології є важливим інструментом для поліпшення якості та ефективності освіти в закладах вищої освіти. Проте впровадження цифровізації повинно бути здійснене з урахуванням усіх можливих проблем і складнощів, що можуть виникнути.
ПОНЯТТЯ «ІННОВАЦІЙНА КОМПЕТЕТНІСТЬ ПЕДАГОГА»
Authors: МАРИНОВСЬКА ОКСАНА
Published: September 2023

У статті науково обґрунтовано зміст, структуру поняття «інноваційна компетентість педагога» з урахуванням нормативно заданого змісту та результатів наукових педагогічних досліджень.
ТЕОРЕТИЧНЕ ОБҐРУНТУВАННЯ СТРУКТУРНО-ФУНКЦІОНАЛЬНОЇ МОДЕЛІ СИСТЕМИ РОЗВИТКУ КОМУНІКАТИВНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ ФАХІВЦІВ З ПСИХОЛОГІЇ
Authors: ШКУРКО АНГЕЛІНА
Published: September 2023

У статті автором проаналізовано науково-педагогічну, методичну та спеціальну літературу з метою теоретичного обґрунтування структурно-функціональної моделі системи розвитку комунікативної компетентності майбутніх фахівців з психології. Науковцем розкрито змістове наповнення кожного з представлених структурних компонентів, а саме: методологічно-цільового, змістовно-процесуального та діагностико-результативного. Автор дійшов висновку, що для ефективності впровадження висвітленої моделі системи необхідним є створення відповідних організаційно-педагогічних умова, зокрема: спеціального розвивального середовище й моніторинг результатів розвитку комунікативної компетентності майбутніх фахівців із психології.
ВИКОРИСТАННЯ ЗАСОБІВ СЦЕНІЧНО-ПЛАСТИЧНОГО ВИЯВУ ДЛЯ РОЗВИТКУ КРЕАТИВНИХ ЗДІБНОСТЕЙ ДІТЕЙ
Authors: ЯКИМЕНКО МАКСИМ
Published: September 2023

У статті порушено проблему розвитку креативних здібностей у дітей засобами сценічно-пластичного вияву. З’ясовано, що розвиток креативних здібностей передбачає систематичний і цілеспрямований процес, який триває протягом усього життя, тому потребує дієвих шляхів удосконалення. Визначено ключові засоби сценічно-пластичного вияву (пластика тіла, танцювальні рухи, поза, жести, динаміка дій і переміщення (темп, ритм, амплітуда виконання рухів), просторове розташування). Висвітлено шляхи розвитку креативних здібностей дітей засобами сценічно-пластичного вияву.
ОСОБЛИВОСТІ ДОСЛІДЖЕНЬ ПЕДАГОГІЧНИХ ІДЕЙ ІВАНА ФРАНКА В ІСТОРИЧНІЙ РЕТРОПЕРСПЕКТИВІ
Authors: МАТКОВСЬКИЙ МИХАЙЛО
Published: September 2023

Досліджуються особливості вивчення педагогічних поглядів Івана Франка в історичній ретроперспективі. З’ясовуються соціокультурні та політичні передумови франкознавства в різні періоди досліджень. Аргументується актуальність усебічного та більш об’єктивного і різнопланового огляду, осмислення його спадщини. Доводиться важливість критичного переосмислення методологічних підходів радянського франкознавства. Обґрунтовується необхідність систематизації педагогічного франкознавства і концептуалізації виховних ідей мислителя. Проведено аксіологічну паралель Франко-сучасність.
Development and functional validation of tarsometatarsal prosthesis
Authors: Diaz Novo Carlos , Mar Haller Walter , Alvarez Ruiz Emiliano , González Castillo Micaela , Bárbaro Cuadra Manuel , Olivera García Mateo
Published: September 2023

Assistive Technology (AT) plays a crucial role in providing aid products, including prostheses to persons with disabilities. Tarsometatarsal (TMT) disarticulation, a type of partial foot amputation, is associated with complex gait disorders. However, there is limited research on the functional impact of TMT prostheses on gait. This study aims to develop and functionally validate a 3D-printed TMT prosthesis using finite element analysis and human motion laboratory studies. A 65-year-old patient with TMT amputation participated. Digital models of the amputated and healthy feet were obtained through 3D scanning. The prosthesis design was created using Fusion 360 software. Finite element analysis validated the prosthesis design. The prosthesis was manufactured using thermofusion printing with a biocompatible thermoplastic elastomer material. Functional validation included walking, running, and the Timed Up and Go test using motion analysis technologies. Finite element analysis demonstrated the structural integrity and safety of the TMT prosthesis during propulsion. The manufacturing process resulted in an adjustable and cost-effective prosthesis. Functional validation revealed improvements in gait quality, symmetry, and spatiotemporal parameters with the prosthesis. Vertical ground reaction forces during walking resembled the normal range, and running performance showed increased symmetry and propulsion velocity. The Timed Up and Go test showed that prostheses reduce time and improve efficiency. The development and functional validation of the 3D-printed TMT prosthesis offer a promising solution for individuals with TMT disarticulation. This approach addresses the need for assistive technologies in low-income countries with limited access to prostheses. Advanced technologies and a patient-centred approach contribute to improving mobility, gait patterns, and overall quality of life for individuals with partial foot amputations. Future research will focus on exploring additional parameters and developing new prostheses to further enhance gait improvements.
PROPERTIES OF NANOSTRUCTURED COMPOSITES OF POLY(VINYLIDENE FLUORIDE) WITH DOPED POLY(3-METHYLTHIOPHENE)
Authors:   V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry NAS of Ukraine, 1, Academician Kukhar Street, Kyiv, 02094, Ukraine, OGURTSOV N.A. , BORYSENKO M.V. ,   Chuiko Institute of Surface Chemistry NAS of Ukraine, 17, General Naumov Street, Kyiv, 03164, Ukraine, PUD A.A. ,   V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry NAS of Ukraine, 1, Academician Kukhar Street, Kyiv, 02094, Ukraine
Published: September 2023

The combination of properties of intrinsically conducting polymers (ICPs) and functional nanostructured template materials opens up prospects for their use in various fields, ranging from bioelectronics to sensors and energy conversion. Successful combinations solve one of the important drawbacks of many ICPs, created by their insolubility and infusibility, and help to achieve their full potential in thermally processable materials. When developing such hybrid materials, it is necessary to take into account the sensitivity of ICP properties to interphase interactions due to extended π-conjugation in these polymers. However, this aspect of ICP-based nanocomposites has not been sufficiently studied yet. In this paper we investigate the effect of template submicron poly(vinylidene fluoride) (PVDF) particles and the nature of the dopant on properties of poly(3-methylthiophene) (P3MT) precipitated as the shell at the PVDF core surface in the course of the 3MT oxidative polymerization. For this purpose, we compare the properties of P3MT phase of the composites with the properties of the neat P3MT doped with dodecylbenzenesulfonate (DBS), perfluorooctanoate (PFO) and chloride anions. In the formed composite core-shell particles the P3MT is in the form of asymmetric nanoparticles which are localized almost exclusively at the surface of PVDF particles. According to the conjugation length, neat polymers form the following series: P3MT-Cl > P3MT-DBS > P3MT-PFO as evidenced by the IR spectral analysis. In their composites the conjugation length of P3MT doped with Cl- does not change noticeably, while for the DBS and PFO anions cases it increases and for the DBS case it exceeds that of Cl- case. X-ray phase analysis showed an increase in the degree of crystallinity of P3MT-Cl and P3MT-DBS phases in the composition of composites by 1.4 and 1.3 times relative to the corresponding values for the neat doped P3MTs. Such an increase can be caused by the influence of the local electric field of the dipoles of the electroactive part of the crystalline phase of PVDF (β- and γ-phase) on the spatial arrangement of charged P3MT macromolecules formed on the surface of PVDF. Thermogravimetric studies show an increase in the thermal stability of the doped P3MT phase of nanocomposites while conductivity measurements reveal a significant effect of the nature of the dopant anion.
FORMATION OF SILVER-CONTAINING FILMS BASED ON POLYELECTROLYTE COMPLEXES BY SPUTTERING DEPOSITION AND THEIR ANTIMICROBIAL AND ANTIVIRAL ACTIVITY
Authors:   Institute of Macromolecular Chemistry of the NAS of Ukraine, 48, Kharkivs’ke shose, Kyiv, 02155, Ukraine, DEMCHENKO V.L. , GONCHARENKO L.A. ,   Institute of Macromolecular Chemistry of the NAS of Ukraine, 48, Kharkivs’ke shose, Kyiv, 02155, Ukraine, RIABOV S.V. ,   Institute of Macromolecular Chemistry of the NAS of Ukraine, 48, Kharkivs’ke shose, Kyiv, 02155, Ukraine, RYBALCHENKO N.P. ,   Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine, 154, Akademika Zabolotny St., Kyiv, 03143, Ukraine, HNATIUK T.T. ,   Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine, 154, Akademika Zabolotny St., Kyiv, 03143, Ukraine, MOZHAEVA L.L. ,   Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine, 154, Akademika Zabolotny St., Kyiv, 03143, Ukraine, ZAREMBA P.YU. ,   Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine, 154, Akademika Zabolotny St., Kyiv, 03143, Ukraine, NAUMENKO K.S. ,   Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine, 154, Akademika Zabolotny St., Kyiv, 03143, Ukraine, ARTIUKH L.O. ,   Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine, 154, Akademika Zabolotny St., Kyiv, 03143, Ukraine, ZAHORODNIA S.D. ,   Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine, 154, Akademika Zabolotny St., Kyiv, 03143, Ukraine, RYBALCHENKO T.V. ,   Taras Shevchenko National University of Kyiv, 60, Volodymyrs’ka St., Kyiv, 01033, Ukraine, KOKHTYCH L.M. ,   Institute of Physics of the NAS of Ukraine, Ukraine, 46, Prospect Nauky, Kyiv, 03680, Ukraine
Published: September 2023

Silver-containing film materials are formed by vacuum sputtering of silver nanoparticles on the surface of polyelectrolyte complexes based on chitosan and sodium salt of carboxymethylcellulose (pectin). The obtained samples were characterized by the methods of wide-angle X-ray scattering and transmission electron microscopy, and their antimicrobial, antiviral and cytotoxic properties were also investigated. The presence of metallic silver on the surface of polyelectrolyte complexes was confirmed by the method of wide-angle X-ray diffraction. It was established that upon sputtering of silver, a ~200 nm thick layer is formed within 5 minutes. It was shown that Na-CMC–Ag–chitosan and pectin–Ag–chitosan samples, formed by silver sputtering, exhibit antimicrobial activity against test cultures of S. aureus, E. coli, P. aeruginosa, and C. albicans. Antiviral activity of samples against influenza A virus and herpes simplex virus type 1 was also established. The obtained samples were not cytotoxic, did not inhibit the viability of MDCK and BHK cell cultures.
Epidemiology of Nontyphoidal Salmonella Bloodstream Infections in Children
Authors: Greenhow Tara L. , Alabaster Amy
Published: September 2023

BACKGROUND

Nontyphoidal Salmonella (NTS) infections are the most common culture-confirmed foodborne illness in the United States. Although extremes of age and chronic or immunosuppressing conditions are known risk factors for NTS bloodstream infection (BSI), further predictors of BSI and BSI with focal infection in children remain poorly understood.

METHODS

This was a retrospective review of NTS-positive blood cultures collected from 1999 to 2018 and stool studies collected from 2009 to 2018 in children. Incidence rates and risk factors for NTS BSI with and without focal infection were determined.

RESULTS

Incidence rates of NTS BSI have not decreased over the last 20 years. There were 211 cases of NTS BSI with an incidence rate of 1.4 per 100 000 children per year. Twenty-one (10%) had underlying comorbidities. S. heidelberg was the most common serotype occurring in 45 (21%) cases. Compared with children with uncomplicated NTS BSI, children with NTS BSI with focal infection were more likely to have an underlying comorbidity, less diarrhea, and higher absolute neutrophil count. On multivariable analysis, the only difference in having NTS BSI in children with NTS gastroenteritis who had blood cultures obtained was a longer duration of fever (4.4 vs 2.5 days), less bloody diarrhea, and S. heidelberg isolated from stool. Laboratory studies, group of NTS, and other symptoms were not significant.

CONCLUSIONS

Clinicians should remain vigilant for NTS BSI in children with prolonged fevers. S. heidelberg is the most common cause of NTS BSI in children and a predictor of BSI in children with NTS gastroenteritis.