bluuebunny/crossref_metadata_2025 huggingface dataset:
Online English dictionaries: An overview of the characteristics of three dictionaries and an analysis of their suitability for students
Authors: Todorović Milan , Spasić Nataša
Published: December 2022

In this paper we have scrutinized three popular monolingual English dictionaries: Longman Dictionary of Contemporary English Online, Oxford Learner's Dictionaries, and Merriam-Webster Dictionary, the online versions of the printed Longman Dictionary of Contemporary English, Oxford Advanced Learner's Dictionary and Merriam-Webster's Collegiate Dictionary. After the introductory part, consisting of a short overview of the general nature and importance of (online) dictionaries in the classroom, we have presented general characteristics that all observed dictionaries have in common. Following this, a more in-depth analysis of the intricacies of the three dictionaries has been given. We have studied the additional functions that each of the dictionaries has (the thesaurus, synonymous expressions, fun facts, quizzes, grammar exercises, etc.). Finally, we have established a connection between this technological innovation and the classroom itself. We have used three factors to determine the suitability and influence of each dictionary: (a) economy; (b) interactivity; (c) simplicity. Our aim was to determine the importance and effectiveness of modern technologies, so that their potential can be implemented in education. Based on the observed data, we can conclude that LDCEO and OLD (given their pedagogical purposes) are more suitable dictionaries for students of English as a foreign language on the primary and high school levels, while MWD, due to its purpose, complexity of language and other advanced features is more suitable for students on higher levels of education.
Repetition figures as a cohesive mechanism in Sava's Life of Saint Simeon
Authors: Jekić Sara
Published: December 2022

At the heart of our research were figures of repetition as a cohesive mechanism in Sava's Life of Saint Simeon. Based on representative examples, the method of working on the text, inductive and deductive reasoning, but also connecting the science of literature and linguistics of the text, we will try to show whether and to what extent the presence of repetition figures contributed to greater coherence of the text. Therefore, our analysis will not be reduced only to lower textual units, but also to higher ones, such as paragraphs, chapters, and the text as a whole, thus trying to penetrate the meaning of its entire organization. Considering that lexical and syntactic repetitions are the most important for textual analysis, i.e. figures that are created by repeating lexemes, phrases or sentences, they are primarily in the focus of research.
Prediction of burnout and work engagement of teachers based on job demands-resources model
Authors: Zubić Ivana
Published: December 2022

The aim of this study was to examine the relationship between elements of the JD-R Model in a sample of teachers from the Republic of Serbia. The sample consisted of 119 teachers who have been working in primary and secondary schools. Work overload was measured by the Workload Scale (Shirom et al., 2010), emotional demands and social support of chiefs were examined by appropriate parts of the Questionnaire on the Experience and Assessment of Work (Van Veldhoven & Meijman, 1994), burnout at work was measured using the Copenhagen Burnout Inventory (CBI), engagement was tested by the UWES - Utrecht Work Engagement Scale (Schaufeli & Bakker, 2004). The results showed statistically significant correlations between work overload, on the one hand, and burnout (r = .570, p <0.01), job engagement (r = -. 291, p <0.01), on the other hand. Correlations were also established between emotional demands, on the one hand, and burnout (r = .513, p <0.01), job engagement (r = -. 185, p <0.05), on the other hand. Statistically significant correlations were found between peer support, on the one hand, and burnout (r = -. 253, p <0.01), job engagement (r = .290, p <0.01) on the other hand. Correlations between support of chiefs, on the one hand, and burnout (r = -. 304, p <0.01), job engagement (r = .156, p <0.05) were also established on the other hand. Statistically significant negative correlations were found between burnout and job engagement (r = -. 598, p <0.01). The results confirmed the assumptions of the JD-R model: 1. an energetic process of wearing out in which high job demands (work overload and emotional demands) exhaust employees' mental and physical resources, therefore, lead to burnout; and 2. a motivational process in which job resources (social support of colleagues and chiefs) foster work engagement.
Multimodal and digital literacy as new concepts in education
Authors: Vidosavljević Milena
Published: December 2022

The digital age requires each individual to redevelop new skills and many literacy skills in order to function in modern society. Therefore, new concepts are emerging in education that explain what all the skills are necessary in order to adequately perform certain activities in the online environment. One of the modern concepts is multimodality, which is inevitably accompanied by modes, multimodal literacy, and digital, as well as broader literacy. Multimodality is a communication phenomenon that relies on the use of modes, i.e., semiotic resources, whose role is to create meaning. Namely, mods include images, charts, sounds, colours, audio, videos, maps and so on. Their function is to help digital texts convey a specific message in an online environment. In all this, the key role is played by multimodal literacy, which is the ability to successfully work with texts that include different modes, as well as digital literacy, which includes the ability to search, locate, select and analyse digital information. Having in mind that both literacies are interconnected and complementary, the aim of this paper is to draw attention to the mentioned concepts as well as to present their importance for the realization of multimodality in education.
A letter from Baron Engelshofen to Patriarch Arsenije IV in 1743
Authors: Popović Aleksa , Mušikić-Popović Ilinka
Published: December 2022

The paper presents a letter from Baron Engelshofen sent at the end of 1743 to Patriarch Arsenije IV (Jovanović Šakabenta), in which the issue of convening the Serbian National-Ecclesial Congress (1744) is considered. Baron Engelshofen here informed the patriarch about his plein potentiel as an imperial commissioner at the assembly, depicted the basis for convening the assembly and asked the patriarch to determine the exact date and number and names of the deputies (deputations) at the assembly. In historiography, the Congress of 1744 was accepted as one of the most important, because it also confirmed the Serbian Privileges by Maria Theresa and their translation into Serbian (i.e., Slavo-Serbian). Therefore, the authors believe that the attached document expands the knowledge about the functioning of Serbian privileged issues in the Habsburg Monarchy during the 18th century. After the Second Migration and the Peace of Belgrade (1739), the question of the status of the Serbian people was addressed. Also, the War for the Austrian Succession (1740-1748) in the first phase brought into question the survival of the Habsburg Monarchy, which brought relations within the state to a new level. Mostly to quell the dissatisfaction of the Serbian people due to the legal article 46/1741 Dieta Posonienssis, which prescribed that only Roman Catholics in Croatia and Slavonia have the right to immovable property, as well as legal article 18/1741, which required the development of Tissa and Moris Frontier and the inclusion of their territories in the Hungarian county system, at the request of the Serb National Deputation. Maria Theresa confirmed the Privileges on April 24, 1740 through the Austrian Court Chancellery and on May 18, 1743 through the Hungarian Court Chancellery declaring them military authorities on August 4, 1743.
English language teachers' professional training: The analysis of the Catalogue of professional development programmes for employees in education
Authors: Kulić Danijela , Kostić-Minić Anđela
Published: December 2022

A continuing professional development of teachers has always been a necessity in education, but nowadays it is acknowledged as a requirement that has to be fulfilled within the scope of teachers' lifelong learning, which means that teachers are provided with many formal opportunities to continuously revise and develop their knowledge and skills after graduation. This paper aims to evaluate the presence of teacher training programmes, offered by the Institute for Improvement of Education and Upbringing, that are specifically created for English language teachers and their development in the subject matter (language skills and systems) and English language teaching methodology. According to the results of the research, there are several conclusions that can be drawn: a huge diversity of topics and aims is found in the Catalogue; majority of training programmes are focused on general topics in education (260), upbringing (166), and additional support (49). Seminars that are specifically designed for foreign language teachers present the minority compared to already mentioned teacher training programmes (21). English language teaching methodology as a field of potential improvement is perceived in only 9 programmes. Unfortunately, programmes through which English language teachers can build upon their knowledge of language systems and skills (phonology, grammar, lexis, discourse, speaking, listening, writing, reading) do not exist within the scope of the analysed Catalogue.
Neverbalno ponašanje kao deo modela opisa komunikativnog ponašanja
Authors: Komadina Isidora
Published: December 2022

Pomoću modela opisa komunikativnog ponašanja koji su ustanovljeni kroz rad Voronješke škole komunikativnog ponašanja, a koji su se u dosadašnjoj praksi koristili konfrontaciono, na ispitanicima, kao i pomoću različitih psiholoških testova (asocijativni eksperimenti različitog tipa, lingvistički intervjui), ispitivali smo neverbalno komunikativno ponašanje na nivou pisanog diskursa, i to udžbeničkih osnovnih tekstova koji se u srpskoj sredini koriste za usvajanje ruskog jezika kroz školski sistem. Analiza sprovedena putem situacionog, aspekatskog i parametarskog modela opisa komunikativnog ponašanja na materijalu udžbeničkih tekstova pokazala je da se prezentovani obrasci komunikativnog ponašanja Rusa iz literature ne poklapaju u potpunosti sa saznanjima iz udžbenika, i da u udžbenicima ne postoji dovoljan broj primera koji ilustruju neverbalno komunikativno ponašanje. Ovaj nedostatak umanjuje mogućnost sticanja sociokulturne kompetencije koja je neophodna za uspešno usvajanje samog jezika.
Freedom of association of judges in Bosnia and Herzegovina
Authors: Milinković Igor
Published: December 2022

Freedom of association is one of the fundamental freedoms and is considered one of the necessary elements of a free society. Isolated from other members of the community, an individual would have little chance of successfully resisting the arbitrariness of the ruler, or fighting for social changes that he deems justified. Although judges are also entitled to this right, the very nature of the judicial office may call for establishing certain restrictions on the exercise of this right in order to protect the dignity of the judicial office and public confidence in the independence and impartiality of the judiciary. The first part of the paper focuses on the importance of exercising the freedom of association of judicial office holders. Special attention will be drawn to the role that professional associations of judges play in preserving the independence of the judiciary and improving its position, as well as protecting the rule of law and a democratic order. After referring to relevant provisions of international documents and the case law of the European Court of Human Rights, the author analyzes the restrictions on the freedom of association of judges adopted in various national legislations. Special attention will be given to the justifiability of prohibiting judges from joining political parties, and the dilemmas arising from the membership of judges in secret societies, i.e. other organizations operating on similar grounds. The second part of the paper focuses on the legal framework of the freedom of association of judges in Bosnia and Herzegovina and the justifiability of restrictions imposed on the exercise of this right.
Public administration during the COVID-19 pandemic and reform directions
Authors: Anđelković Jovana
Published: December 2022

During the COVID-19 pandemic, caused by the SARS-CoV-2 virus, every form of company organization and operation has undergone certain changes. The global crisis has highlighted the role of the state and the public sector in emergency situations and tested their readiness to respond to the challenges posed by the pandemic by instituting adaptable and pragmatic solutions while respecting the rule of law. During the pandemic, state and local officials have faced huge challenges. Being obliged to deal with rapidly and constantly changing circumstances, they often had to resort to improvisations. In such an extremely difficult context, it was of great importance to avoid administrative barriers, which could result in the loss of valuable time during the crisis. The pandemic has revealed many weaknesses in the functioning of state and local governments across Europe, including organization issues, change of workplace (from office to home environment), a new mode of interaction with citizens, etc. In developing countries, inadequate legislative provisions, technical solutions and insufficient digitalization have contributed to slowing down the administrative procedures. The aim of this paper is to indicate the problems faced by state administrations and local governments during the COVID-19 pandemic, to highlight the examples of good practices, and to indicate the reform directions after the pandemic.
Experimental determination of residual stresses in structure by hole drilling method
Authors: Manjgo Mersida , Vuherer Tomaž , Manjgo Mirza , Buzić Meri
Published: December 2022

A very important segment, which occurs as a result of welding, is the occurrence of residual stresses in welded structures. The effects of residual stresses can be beneficial or harmful to the structure, depending on their size, sign, and stress distribution in relation to the stresses caused by the external load itself. Therefore, the examination of residual stresses is very important because they significantly affect the formation and growth of cracks, the appearance of brittle fractures, material fatigue, etc. The paper presents the test procedure for measuring residual stresses by the method of "hole drilling" and the possibility of practical application of knowledge about residual stresses in order to improve the quality of machine parts and the structure itself.
Los poderes privados de dominio social y el surgimiento de una especie de nueva pluralidad de producción jurídica propia de la globalización: el globalismo como efecto político.
Authors: Villacorta Caño-Vega Antonio
Published: December 2022

El propósito de este análisis es acercarnos a una comprensión más sistemática de la naturaleza y las consecuencias de la globalización(globalizaciones) contemporánea, en cuanto los cambios políticos que conlleva nos han colocado ante una vasta diversidad histórica, política y cultural que se muestra impermeable a las explicaciones convencionales. La globalización, el globalismo, la mundialización financiera y la desregulación de los mercados y su relación con la gobernanza pública, es uno de los temas clave de nuestro tiempo. Se apuntan así algunos significados y consecuencias de estos términos y, quizás lo que es más importante, por contraste, qué no significan.
El rechazo en el plebiscito chileno de 4 de septiembre de 2022: perspectivas constitucionales
Authors: Zúñiga Urbina Francisco
Published: December 2022

El resultado del plebiscito de salida del 4 de septiembre de 2022 dio término en Chile a un proceso constituyente diseñado en el Acuerdo por la Paz Social y la Nueva Constitución de 15 de noviembre de 2019; y, en consecuencia, con el “rechazo” en urnas se desecha la propuesta de nueva Constitución elaborada por la Convención Constitucional. Pero ello no significó el término del “momento constitucional”, el que se inició en 2011, con momentos débiles y momentos fuertes. En el presente, sobre el proceso constituyente, existe un inquietante status quo. Por ello, se hace necesario abordar, en este marco, cuáles serían los nuevos escenarios que se proyectan desde este hito de cierre: actualmente, Chile se encuentra en la disyuntiva entre dos hipótesis: una “diabólica”, que frustra los afanes de cambio, y una “angelical”, que permite encauzarlos.
La emergencia en el sistema jurídico y la conjetura de Poincaré. Una revisión crítica de la literatura
Authors: Álvarez Álvarez Leonardo
Published: December 2022

Este trabajo analiza el tratamiento de la emergencia en el sistema jurídico desde la perspectiva de la conjetura planteada por Henri Poincaré en el ámbito de la topología en 1904. Una conjetura que fue resuelta finalmente en tres trabajos publicados en los años 2002 y 2003 por el matemático ruso Grigori Perelman. También la emergencia en el sistema jurídico nace también como un conjunto de hipótesis materialmente similares a las presentadas por la conjetura de Poincaré. Sin embargo, este trabajo quiere demostrar que, contrariamente a lo que ha sucedido con dicha conjetura, los poderes de emergencia no aún han sido objeto de adecuada demostración científica. Y ello por dos motivos. Primero, porque sus hipótesis de desarrollan en el contexto de teorías del conocimiento distintas y porque han querido introducir en su demostración una premisa no necesariamente compatible con las hipótesis que se erigen en su punto de partida.
De la ruptura ideológica al Plenario de Parlamentarios del País Valenciano
Authors: Aznar i Garcia Ramón
Published: December 2022

En 2022 se cumplen cuarenta años de la promulgación del estatuto de autonomía de la Comunitat Valenciana, e interesa llevar a cabo una aproximación histórica jurídica a aquel proceso. El artículo analiza el surgimiento del conflicto identitario que afectó de lleno a la transición democrática valenciana, la crisis del organismo unitario de la oposición democrática valenciana a raíz de su no consideración como actor de la reforma política española, así como el inicio de la negociación de la preautonomía valenciana.
Near-field optical characterization of atomic structures and polaritons in twisted two-dimensional materials
Authors: Xu Kun-Qi , Hu Cheng , Shen Pei-Yue , Ma Sai-Qun , Zhou Xian-Liang , Liang Qi , Shi Zhi-Wen ,   Key Laboratory of Artificial Structures and Quantum Control (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China
Published: December 2022

Polariton is a quasiparticle generated from strong interaction between a photon and an electric or magnetic dipole-carrying excitation. These polaritons can confine light into a small space that is beyond the diffraction limit of light, thus have greatly advanced the development of nano photonics, nonlinear optics, quantum optics and other related research. Van der Waals two-dimensional (2D) crystals provide an ideal platform for studying nano-polaritons due to reduced material dimensionality. In particular, stacking and twisting offer additional degree of freedom for manipulating polaritons that are not available in a single-layer material. In this paper, we review the near-field optical characterizations of various structures and polaritonic properties of stacked/twisted 2D crystals reported in recent years, including domain structures of stacked few-layer graphene, moiré superlattice structures of twisted 2D crystals, twisted topological polaritons, and twisted chiral plasmons. We also propose several exciting directions for future study of polaritons in stacked/twisted 2D crystals.
Procedimiento de fiscalización y sanción de FONASA a prestadores privados de salud. Comentario del caso Bertoli García con Ministerio de Salud
Authors:   Universidad de Tarapacá, Vinet Vega Javiera
Published: December 2022

El presente trabajo busca analizar el procedimiento de fiscalización y sanción de FONASA respecto de los prestadores privados de salud en modalidad de libre elección, a partir de la sentencia de la Corte de Apelaciones Santiago Rol N° 792-2020 que resuelve una reclamación en esta materia. Ello, a fin de formular algunas precisiones en torno a la garantía de defensa del afectado, frente al rol que cumple el fiscalizador a lo largo del procedimiento y las prerrogativas de que goza este último en la generación de prueba durante la etapa de fiscalización.
Modernismos divergentes (1910-1915): las dramaturgias musicales del “malogrado” Usandizaga
Authors:   Conservatorio Juan Crisóstomo de Arriaga (España), Lerena Mario
Published: December 2022

La fama del compositor José María Usandizaga (1887-1915) se ha sustentado fundamentalmente en dos éxitos teatrales: Mendi-Mendiyan (Bilbao, 1910) y, sobre todo, Las golondrinas (Madrid, 1914). No obstante, la documentación personal conservada en el Archivo Vasco de la Música-ERESBIL y algunos testimonios históricos proporcionan materiales para el estudio de otros proyectos escénicos nonatos o póstumos, como la conocida ópera La llama o la olvidada “comedia lírica” Bitz, entre otros. Partiendo de esas fuentes inéditas presentamos un análisis contextualizado de los aspectos dramatúrgicos y estilísticos más salientes de dicho repertorio. Se evidencia así un sostenido empeño por triunfar en la escena lírica contemporánea adaptándose a las demandas culturales de su entorno, desde el ideal de la ópera nacional hasta el “teatro de arte” modernista, pasando por expresiones más comerciales de “género ínfimo”. Quedan patentes, asimismo, aspectos relevantes del Modernismo musical español, como su ambigua conexión con corrientes artísticas internacionales y su coyuntura divergente a la muerte del compositor.
Obtaing Organomineral Fertilizers on Base of Local Raw Materials and Nitrogen-fixing Microorganisms
Authors: Zukhriddin Vokkosov , Murodillaevich Kanoatov Khairullo , Elbekovich Sultonov Boxodir
Published: December 2022

The article presents results of research on the production of organomineral fertilizers based on local raw materials cattle manure (CM), Kyzylkum phosphorite flour (FF) and Navbahor bentonite (NB) and nitrogen-fixing microorganisms (NFM). CM: NB: NFM=100.0: 2.5: (0-4) and CM: NB: FF: NFM= 100.0: 5.0: 2.5: (0-4) in obtaining new types of organomineral fertilizers ratios are used. Composting time is taken from 1 day to 60 days. The physico-chemical and commercial properties of the obtained new type of organomineral fertilizers were studied. The contents of organomineral fertilizer samples were analyzed by modern physico-chemical methods.

Composting local ores (FU and NB) with cattle manure and processing the resulting mixture with a solution containing nitrogen-fixing microorganisms led to an increase in humic substances, a plant-available form of phosphorus and, most importantly, an increase in nutrient components. Determined that the amount of nitrogen in the organomineral fertilizer obtained due to the biofixation of atmospheric molecular nitrogen is 3.2-4.1 times higher than in the case where NFM was not applied.
Utilization of Left over Peach Pulp for Making Puree after Canning of Peach–Halves in Peach Fruit Juice
Authors: Choudhury Shahida , Deka Bidyut C. , Sema Akali
Published: December 2022

Peach fruits of the cultivar TA-170 were lye peeled and canned in A2 ½ tin cans with a covering medium of 400 Brix containing enzymatically extracted fruit juice in a concentration of 30-40 per cent with or without ascorbic acid (500 ppm) and compared with the control (400 Brix of sucrose syrup + 0.3% citric acid). Cut out analysis carried out upto 6 months with 2 months storage interval, revealed that all the treatments met FPO specification for drained weight and showed superiority in quality over conventional canned peaches. The vitamin C fortified treatments had a higher retention of ascorbic acid throughout the storage as compared to the unfortified treatments. In comparison to peach halves canned in juice with or without ascorbic acid in the covering medium, more non-enzymatic browning was seen in the peach halves canned in plain sucrose syrup.
Association Between Antiepileptic Drugs and Incident Parkinson Disease
Authors: Belete Daniel , Jacobs Benjamin M. , Simonet Cristina , Bestwick Jonathan P. , Waters Sheena , Marshall Charles R. , Dobson Ruth , Noyce Alastair J.
Published: December 2022

Importance

Recent studies have highlighted an association between epilepsy and Parkinson disease (PD). The role of antiepileptic drugs (AEDs) has not been explored.

Objective

To investigate the association between AEDs and incident PD.

Design, Setting, and Participants

This nested case-control study started collecting data from the UK Biobank (UKB) in 2006, and data were extracted on June 30, 2021. Individuals with linked primary care prescription data were included. Cases were defined as individuals with a Hospital Episode Statistics (HES)–coded diagnosis of PD. Controls were matched 6:1 for age, sex, race and ethnicity, and socioeconomic status. Prescription records were searched for AEDs prescribed prior to diagnosis of PD. The UKB is a longitudinal cohort study with more than 500 000 participants; 45% of individuals in the UKB have linked primary care prescription data. Participants living in the UK aged between 40 and 69 years were recruited to the UKB between 2006 and 2010. All participants with UKB-linked primary care prescription data (n = 222 106) were eligible for enrollment in the study. Individuals with only a self-reported PD diagnosis or missing data for the matching variables were excluded. In total, 1477 individuals were excluded; 49 were excluded due to having only self-reported PD, and 1428 were excluded due to missing data.

Exposures

Exposure to AEDs (carbamazepine, lamotrigine, levetiracetam, and sodium valproate) was defined using routinely collected prescription data derived from primary care.

Main Outcomes and Measures

Odds ratios and 95% CIs were calculated using adjusted logistic regression models for individuals prescribed AEDs before the first date of HES-coded diagnosis of PD.

Results

In this case-control study, there were 1433 individuals with an HES-coded PD diagnosis (cases) and 8598 controls in the analysis. Of the 1433 individuals, 873 (60.9%) were male, 1397 (97.5%) had their race and ethnicity recorded as White, and their median age was 71 years (IQR, 65-75 years). An association was found between AED prescriptions and incident PD (odds ratio, 1.80; 95% CI, 1.35-2.40). There was a trend for a greater number of prescription issues and multiple AEDs being associated with a greater risk of PD.

Conclusions and Relevance

This study, the first to systematically look at PD risk in individuals prescribed the most common AEDs, to our knowledge, found evidence of an association between AEDs and incident PD. With the recent literature demonstrating an association between epilepsy and PD, this study provides further insights.
A comparison of the design processes of the Yoyogi National Gymnasium and the Kagawa Prefectural Gymnasium
Authors: Toyokawa Saikaku
Published: December 2022

This article compares the design processes for the Yoyogi National Gymnasium and the Kagawa Prefectural Gymnasium. It analyzes the sketches and plans for both buildings that Kenzo Tange drew in his pocketbooks, and the commentary and illustrations after the structures were completed. The analysis reveals that Tange researched suspended roof designs worldwide, placed importance on communicating with his office staff and engineers, and maintained his approach of integrating architectural planning, structural drawing, and ductwork while designing the two buildings.
Evaluation of a workflow for cone‐beam CT‐guided online adaptive palliative radiotherapy planned using diagnostic CT scans
Authors: Nelissen Koen J. , Versteijne Eva , Senan Suresh , Hoffmans Daan , Slotman Ben J. , Verbakel Wilko F. A. R.
Published: December 2022

Purpose

Single‐visit radiotherapy (RT) is beneficial for patients requiring pain control and can limit interruptions to systemic treatments. However, the requirement for a dedicated planning CT (pCT)‐scan can result in treatment delays. We developed a workflow involving preplanning on available diagnostic CT (dCT) imaging, followed by online plan adaption using a cone‐beam CT (CBCT)‐scan prior to RT‐delivery, in order to account for any changes in anatomy and target position.

Methods

Patients previously treated with palliative RT for bone metastases were selected from our hospital database. Patient dCT‐images were deformed to treatment CBCTs in the Ethos platform (Varian Medical Systems) and a synthetic CT (sCT) generated. Treatment quality was analyzed by comparing a coverage of the V95% of the planning/clinical target volume and different organ‐at‐risk (OAR) doses between adapted and initial clinical treatment plans. Doses were recalculated on the CBCT and sCT in a separate treatment planning system. Adapted plan doses were measured on‐couch using an anthropomorphic phantom with a Gafchromic EBT3 dosimetric film and compared to dose calculations.

Results

All adapted treatment plans met the clinical goals for target and OARs and outperformed the original treatment plans calculated on the (daily) sCT. Differences in V95% of the target volume coverage between the initial and adapted treatments were <0.2%. Dose recalculations on CBCT and sCT were comparable, and the average gamma pass rate (3%/2 mm) of dosimetric measurements was 98.8%.

Conclusions

Online daily adaptive RT using dCTs instead of a dedicated pCT is feasible using the Ethos platform. This workflow has now been implemented clinically.
Commissioning and performance evaluation of commercially available mobile imager for image guided total body irradiation
Authors: Nakaichi Tetsu , Okamoto Hiroyuki , Kon Mitsuhiro , Takaso Kazuki , Aikawa Ako , Nakamura Satoshi , Ijima Kotaro , Chiba Takahito , Nakayama Hiroki , Takemori Mihiro , Mikasa Shohei , Fujii Kyohei , Urago Yuka , Goka Tomonori , Shimizu Yuri , Igaki Hiroshi
Published: December 2022

Background

The setup of lung shield (LS) in total body irradiation (TBI) with the computed radiography (CR) system is a time‐consuming task and has not been quantitatively evaluated. The TBI mobile imager (TBI‐MI) can solve this problem through real‐time monitoring. Therefore, this study aimed to perform commissioning and performance evaluation of TBI‐MI to promote its use in clinical practice.

Methods

The source‐axis distance in TBI treatment, TBI‐MI (CNERGY TBI, Cablon Medical B.V.), and the LS position were set to 400, 450, and 358 cm, respectively. The evaluation items were as follows: accuracy of image scaling and measured displacement error of LS, image quality (linearity, signal‐to‐noise ratio, and modulation transfer function) using an EPID QC phantom, optimal thresholding to detect intra‐fractional motion in the alert function, and the scatter radiation dose from TBI‐MI.

Results

The accuracy of image scaling and the difference in measured displacement of the LS was <4 mm in any displacements and directions. The image quality of TBI imager was slightly inferior to the CR image but was visually acceptable in clinical practice. The signal‐to‐noise ratio was improved at high dose rate. The optimal thresholding value to detect a 10‐mm body displacement was determined to be approximately 5.0%. The maximum fraction of scattering radiation to irradiated dose was 1.7% at patient surface.

Conclusion

MI‐TBI can quantitatively evaluate LS displacement with acceptable image quality. Furthermore, real‐time monitoring with alert function to detect intrafraction patient displacement can contribute to safe TBI treatment.
A 2.20 eV Bandgap Polymer Donor for Efficient Colorful Semitransparent Organic Solar Cells
Authors: Xie Dongsheng , Zhang Yue , Yuan Xiyue , Li Youle , Huang Fei , Cao Yong , Duan Chunhui
Published: December 2022

Semitransparent organic solar cells (ST‐OSCs) have attracted increasing attention due to their promising prospect in building‐integrated photovoltaics. Generally, efficient ST‐OSCs with good average visible transmittance (AVT) can be realized by developing active layer materials with light absorption far from the visible light range. Herein, the development of ultrawide bandgap polymer donors with near‐ultraviolet absorption, paired with near‐infrared acceptors, is proposed to achieve high‐performance ST‐OSCs. The key points for the design of ultrawide bandgap polymers include constructing donor–donor type conjugated skeleton, suppressing the quinoidal resonance effect, and minimizing the twist of conjugated skeleton via noncovalent conformational locks. As a proof of concept, a polymer named PBOF with an optical bandgap of 2.20 eV is synthesized, which exhibited largely reduced overlap with the human eye photopic response spectrum and afforded a power conversion efficiency (PCE) of 16.40% in opaque device. As a result, ST‐OSCs with a PCE over 10% and an AVT over 30% are achieved without optical modulation. Moreover, colorful ST‐OSCs with visual aesthetics can be achieved by tuning the donor/acceptor weight ratio in active layer benefiting from the ultrawide bandgap nature of PBOF. This study demonstrates the great potential of ultrawide bandgap polymers for efficient colorful ST‐OSCs.
Biomaterials‐Based Cell Therapy for Myocardial Tissue Regeneration
Authors: Mu Lei , Dong Ruonan , Guo Baolin
Published: December 2022

Cardiovascular diseases (CVDs) have been the leading cause of death worldwide during the past several decades. Cell loss is the main problem that results in cardiac dysfunction and further mortality. Cell therapy aiming to replenish the lost cells is proposed to treat CVDs especially ischemic heart diseases which lead to a big portion of cell loss. Due to the direct injection's low cell retention and survival ratio, cell therapy using biomaterials as cell carriers has attracted more and more attention because of their promotion of cell delivery and maintenance at the aiming sites. In this review, the three main factors involved in cell therapy for myocardial tissue regeneration: cell sources (somatic cells, stem cells, and engineered cells), chemical components of cell carriers (natural materials, synthetic materials, and electroactive materials), and categories of cell delivery materials (patches, microspheres, injectable hydrogels, nanofiber and microneedles, etc.) are systematically summarized. An introduction of the methods including magnetic resonance/radionuclide/photoacoustic and fluorescence imaging for tracking the behavior of transplanted cells in vivo is also included. Current challenges of biomaterials‐based cell therapy and their future directions are provided to give both beginners and professionals a clear view of the development and future trends in this area.
Oral Delivery of siRNA Using Fluorinated, Small‐Sized Nanocapsules toward Anti‐Inflammation Treatment
Authors: Wei Yuansong , Li Xudong , Lin Juanhui , Zhou Yang , Yang Jiandong , Hou Mengying , Wu Fan , Yan Jing , Ge Chenglong , Hu Duanmin , Yin Lichen
Published: December 2022

Oral delivery of small interfering RNA (siRNA) provides a promising paradigm for treating diseases that require regular injections. However, the multiple gastrointestinal (GI) and systemic barriers often lead to inefficient oral absorption and low bioavailability of siRNA. Technologies that can overcome these barriers are still lacking, which hinders the clinical potential of orally delivered siRNA. Herein, small‐sized, fluorinated nanocapsules (F‐NCs) are developed to mediate efficient oral delivery of tumor necrosis factor α (TNF‐α) siRNA for anti‐inflammation treatment. The NCs possess a disulfide‐cross‐linked shell structure, thus featuring robust stability in the GI tract. Because of their small size (≈30 nm) and fluorocarbon‐assisted repelling of mucin adsorption, the best‐performing F3‐NCs show excellent mucus penetration and intestinal transport capabilities without impairing the intestinal tight junction, conferring the oral bioavailability of 20.4% in relative to intravenous injection. The disulfide cross‐linker can be cleaved inside target cells, causing NCs dissociation and siRNA release to potentiate the TNF‐α silencing efficiency. In murine models of acute and chronic inflammation, orally delivered F3‐NCs provoke efficient TNF‐α silencing and pronounced anti‐inflammatory efficacies. This study therefore provides a transformative strategy for oral siRNA delivery, and will render promising utilities for anti‐inflammation treatment.
TRAPPC9‐related neurodevelopmental disorder: Report of a homozygous deletion in TRAPPC9 due to paternal uniparental isodisomy
Authors: Penon‐Portmann Monica , Hodoglugil Ugur , Arun P Wiita , Yip Tiffany , Slavotinek Anne , Tenney Jessica L.
Published: December 2022

TRAPPC9 loss‐of‐function biallelic variants are associated with an autosomal recessive intellectual disability syndrome (Online Mendelian Inheritance of Man no. 613192), also characterized by microcephaly, hypertelorism, obesity, growth delay, and behavioral differences. Here, we describe an 8‐year‐old Hispanic female with neurodevelopmental disorder, partial epilepsy, microcephaly, bilateral cleft lip and alveolus, growth delay, and dysmorphic features. She had abnormal myelination, mega cisterna magna, and colpocephaly on brain magnetic resonance imaging (MRI). Microarray showed a single ~146 Mb region of homozygosity (ROH) encompassing all of Chromosome 8, consistent with uniparental isodisomy (UPD). Exome sequencing performed in‐house did not identify single nucleotide variants to explain her phenotype. Algorithms developed in‐house and further evaluation of BAM files revealed a homozygous deletion overlapping Exon 2 in TRAPPC9 within the ROH. Subsequent del/dup analyses with exon‐level oligo array confirmed a likely pathogenic deletion in TRAPPC9 (NM_031466.5): arr[GRCh37] 8q24.3(141460661_141461780)x0. Our case highlights the implications of downstream analyses from UPD/ROH given the increased risk for AR conditions, the strengths of combining orthologous molecular methods to establish a diagnosis and further delineates the TRAPPC9‐related phenotype in an individual of Hispanic ancestry.
Superconductivity in an Orbital‐Reoriented SnAs Square Lattice: A Case Study of Li0.6Sn2As2 and NaSnAs
Authors: Wang Junjie , Ying Tianping , Deng Jun , Pei Cuiying , Yu Tongxu , Chen Xu , Wan Yimin , Yang Mingzhang , Dai Weiyi , Yang Dongliang , Li Yanchun , Li Shiyan , Iimura Soshi , Du Shixuan , Hosono Hideo , Qi Yanpeng , Guo Jian‐gang
Published: December 2022

Searching for functional square lattices in layered superconductor systems offers an explicit clue to modify the electron behavior and find exotic properties. The trigonal SnAs3 structural units in SnAs‐based systems are relatively conformable to distortion, which provides the possibility to achieve structurally topological transformation and higher superconducting transition temperatures. In the present work, the functional As square lattice was realized and activated in Li0.6Sn2As2 and NaSnAs through a topotactic structural transformation of trigonal SnAs3 to square SnAs4 under pressure, resulting in a record‐high Tc among all synthesized SnAs‐based compounds. Meanwhile, the conductive channel transfers from the out‐of‐plane pz orbital to the in‐plane px+py orbitals, facilitating electron hopping within the square 2D lattice and boosting the superconductivity. The reorientation of p‐orbital following a directed local structure transformation provides an effective strategy to modify layered superconducting systems.
Tuning the CO2 Hydrogenation Selectivity of Rhodium Single‐Atom Catalysts on Zirconium Dioxide with Alkali Ions
Authors: Li Shang , Xu Yuxing , Wang Hengwei , Teng Botao , Liu Qin , Li Qiuhua , Xu Lulu , Liu Xinyu , Lu Junling
Published: December 2022

Tuning the coordination environments of metal single atoms (M1) in single‐atom catalysts has shown large impacts on catalytic activity and stability but often barely on selectivity in thermocatalysis. Here, we report that simultaneously regulating both Rh1 atoms and ZrO2 support with alkali ions (e.g., Na) enables efficient switching of the reaction products from nearly 100 % CH4 to above 99 % CO in CO2 hydrogenation in a wide temperature range (240–440 °C) along with a record high activity of 9.4 molCO gRh−1 h−1 at 300 °C and long‐term stability. In situ spectroscopic characterization and theoretical calculations unveil that alkali ions on ZrO2 change the surface intermediate from formate to carboxy species during CO2 activation, thus leading to exclusive CO formation. Meanwhile, alkali ions also reinforce the electronic Rh1‐support interactions, endowing the Rh1 atoms more electron deficient, which improves the stability against sintering and inhibits deep hydrogenation of CO to CH4.
Phase Transformation of VO2/rGO Composites as High‐Voltage Cathodes in Zinc‐Ion Batteries
Authors: Li Yuying , Wang Jingyi , Tian Zhihong , Lai Feili , Liu Tianxi , He Guanjie
Published: December 2022

Aqueous zinc‐ion batteries (ZIBs) are becoming widely concerned candidates as stationary and safe energy storage technology. Vanadium oxides display promising role as cathodes for ZIBs owing to their inherent merits in structures and multiple valence states. However, their unsatisfactory electrical conductivity and narrow voltage window hinder the practical application. Moreover, the charge storage mechanism at the high voltage is unclear. Herein, we synthesized VO2/rGO composites with high electrical conductivity and demonstrated an electrochemically induced phase transition from tunneled VO2/rGO to Zn3(OH)2V2O7 ⋅ 2H2O/rGO with a laminated structure and an enhanced interlayer spacing during the first charge to 1.6 V, which shows preferable Zn2+ storage capacity. Concretely, the electrochemical window of as‐assembled ZIB expands to 1.6 V with a specific capacity of 329.9 mAh g−1 at 0.1 A g−1, exhibiting wider window compared with the ZIBs based vanadium oxide reported previously. Simultaneously, a long stable lifetime of 84 % capacity retention over 1,000 cycles can be recorded. Our work opens a new idea of design strategy to develop high‐voltage ZIBs.
Oncology distress screening within predominately Black Veterans: Outcomes on supportive care utilization, hospitalizations, and mortality
Authors: Azizoddin Desiree R. , Allsop Matthew , Farah Subrina , Salim Farah , Hauser Joshua , Baltazar Ashton R. , Molokie Robert , Weber Jane , Weldon Christine , Feldman Lawrence , Martin Joanna L.
Published: December 2022

Background

We evaluated whether patients' initial screening symptoms were related to subsequent utilization of supportive care services and hospitalizations, and whether patient‐level demographics, symptoms, hospitalizations, and supportive care service utilization were associated with mortality in primarily low‐income, older, Black Veterans with cancer.

Methods

This quality improvement project created collaborative clinics to conduct cancer distress screenings and refer to supportive care services at an urban, VA medical center. All patients completed a distress screen with follow‐up screening every 3 months. Supportive care utilization, hospitalization rates, and mortality were abstracted through medical records. Poisson regression models and cox proportional hazard models were utilized.

Results

Five hundred and eighty five screened patients were older (m = 72), mostly Black 70% (n = 412), and had advanced cancer 54%. Fifty‐eight percent (n = 340) were screened only once with 81% (n = 470) receiving ≥1 supportive care service and 51.5% (n = 297) being hospitalized ≥1 time 18 months following initial screen. Symptom severity was significantly related to number of hospitalizations. Low mood was significantly related to higher supportive services (p < 0.001), but not hospitalizations (p ≥ 0.52). Pain, fatigue, physical function, nutrition, and physical symptoms were significantly associated with more supportive services and hospitalizations (p < 0.01). Twenty percent (n = 168) died; Veterans who were Black, had lower stage cancers, better physical health, and utilized less supportive care services had lower odds of mortality (p ≤ 0.01).

Conclusion

Individuals with elevated distress needs and those reporting lower physical function utilized more supportive care services and had higher hospitalization rates. Lower physical function, greater supportive care use, higher stage cancer, and being non‐Black were associated with higher odds of death.
Downstream effects of high patient volume pressure on PHPs: A child psychiatry trainee's perspective
Authors: Rider Jeannine
Published: December 2022

Rhode Island boasts some of the most robust access to specialized child and adolescent mental health care across the country, with one of the highlights being the unique access to various levels of care. Child and adolescent psychiatry applicants from across the country are attracted to the breadth of program variety. In particular, Rhode Island uniquely possesses a significant number of specialized partial hospitalization programs (PHP) for children and teens, some of which are nationally recognized and appeal to patients and families throughout the United States.
Direct oral anticoagulant versus antiplatelet therapy following transcatheter aortic valve replacement in patients without prior or concurrent indication for anticoagulation: A meta‐analysis of randomized studies
Authors: Barbosa Moreira Matheus José , Peixoto Natália Araújo do Amaral , Udoma‐Udofa Ofonime Chantal , de Lucena Silva Araújo Sílvia , Enriquez Shirley Katherine Tinajero
Published: December 2022

Introduction

The antithrombotic management following transcatheter aortic valve replacement (TAVR) in patients who do not have a concurrent indication for long‐term anticoagulation therapy is an ongoing source of debate.

Methods

We performed a systematic review and meta‐analysis to compare direct oral anticoagulants (DOACs) versus antiplatelet therapy after TAVR in patients without a concomitant indication for chronic oral anticoagulation. PubMed, Embase, and Cochrane databases were searched. Only randomized controlled trials were included. Risk ratios (RR) with p < 0.05 were considered statistically significant.

Results

Three studies were included, with 2922 patients who underwent TAVR, of whom 1463 (50.1%) received DOACs. Patients who received DOACs therapy had significantly higher all‐cause mortality (RR: 1.68; 95% confidence intervals [CI]: 1.22−2.30; p = 0.001) and non‐cardiovascular mortality (RR: 2.33; 95% CI: 1.13−4.80; p = 0.02). The incidence of major bleeding was not significantly different between the groups (5.3% vs. 3.8%; RR: 1.44; 95% CI: 0.90−2.32; p = 0.13). There was no difference between DOACs and antiplatelet therapy in terms of: ischemic stroke (RR: 1.28; 95% CI: 0.76−2.15; p = 0.35) and cardiovascular mortality (RR: 1.36; 95% CI: 0.92−2.03; p = 0.13). Lastly, the DOACs group had a significantly lower risk of valve thrombosis than the antiplatelet group (0.8% vs. 3.2%; RR: 0.27; 95% CI: 0.14−0.51; p < 0.0001).

Conclusion

In this meta‐analysis of randomized studies comparing DOACs to antiplatelet therapy after TAVR in patients without a concomitant indication for anticoagulation, DOACs were associated with a lower incidence of valve thrombosis and a higher rate of all‐cause mortality, driven by an increase in noncardiac causes of death.
Endoscopic resection of Intralabyrinthine Schwannoma followed by Cochlear implantation
Authors: Lohnherr Vera , Anschuetz Lukas , Mantokoudis Georgios , Caversaccio Marco , Weder Stefan
Published: December 2022

We present the case of a 65 years old patient who developed a complete, sensorineural hearing loss on the right side due to an intravestibular schwannoma. Our video shows a transcanal, endoscopic approach with complete schwannoma removal on the right side, subsequent e‐BERA recordings, and cochlear implantation.