bluuebunny/crossref_metadata_2025 huggingface dataset:
Does It Matter What She Wants? The Role of Individual Preferences Against Unmarried Motherhood in Young Women’s Likelihood of a Nonmarital First Birth
Authors: Shattuck Rachel M.
Published: July 2017

Most young people in the United States express the desire to marry. Norms at all socioeconomic levels posit marriage as the optimal context for childbearing. At the same time, nonmarital fertility accounts for approximately 40 % of U.S. births, experienced disproportionately by women with educational attainment less than a bachelor’s degree. Research has shown that women’s intentions for the number and timing of children and couples’ intent to marry are strong predictors of realized fertility and marriage. The present study investigates whether U.S. young women’s preferences about nonmarital fertility, as stated before childbearing begins, predict their likelihood of having a nonmarital first birth. I track marriage and fertility histories through ages 24–30 of women asked at ages 11–16 whether they would consider unmarried childbearing. One-quarter of women who responded “no” in fact had a nonmarital birth by age 24–30. The ability of women and their partners to access material resources in adulthood were, as expected, the strongest predictors of the likelihood of nonmarital childbearing. Nonetheless, I find that women who said they would not consider nonmarital childbearing had substantially higher hazards of fertility postponement and especially of marital fertility, even after controlling for race/ethnicity, mother’s educational attainment, family of origin intactness, self-efficacy and planning ability, perceived future prospects, and markers of own educational attainment and work experience into early adulthood.
Influence of Proximity to Kin on Residential Mobility and Destination Choice: Examining Local Movers in Metropolitan Areas
Authors: Spring Amy , Ackert Elizabeth , Crowder Kyle , South Scott J.
Published: July 2017

A growing body of research has examined how family dynamics shape residential mobility, highlighting the social—as opposed to economic—drivers of mobility. However, few studies have examined kin ties as both push and pull factors in mobility processes or revealed how the influence of kin ties on mobility varies across sociodemographic groups. Using data on local residential moves from the Panel Study of Income Dynamics (PSID) from 1980 to 2013, we find that location of noncoresident kin influences the likelihood of moving out of the current neighborhood and the selection of a new destination neighborhood. Analyses of out-mobility reveal that parents and young adult children living near each other as well as low-income adult children living near parents are especially deterred from moving. Discrete-choice models of neighborhood selection indicate that movers are particularly drawn to neighborhoods close to aging parents, white and higher-income households tend to move close to parents and children, and lower-income households tend to move close to extended family. Our results highlight the social and economic trade-offs that households face when making residential mobility decisions, which have important implications for broader patterns of inequality in residential attainment.
Attention by design: Using attention checks to detect inattentive respondents and improve data quality
Authors: Abbey James D. , Meloy Margaret G.
Published: July 2017

This paper examines attention checks and manipulation validations to detect inattentive respondents in primary empirical data collection. These prima facie attention checks range from the simple such as reverse scaling first proposed a century ago to more recent and involved methods such as evaluating response patterns and timed responses via online data capture tools. The attention check validations also range from easily implemented mechanisms such as automatic detection through directed queries to highly intensive investigation of responses by the researcher. The latter has the potential to introduce inadvertent researcher bias as the researcher's judgment may impact the interpretation of the data. The empirical findings of the present work reveal that construct and scale validations show consistently significant improvement in the fit statistics—a finding of great use for researchers working predominantly with scales and constructs for their empirical models. However, based on the rudimentary experimental models employed in the analysis, attention checks generally do not show a consistent, systematic improvement in the significance of test statistics for experimental manipulations. This latter result indicates that, by their very nature, attention checks may trigger an inherent trade‐off between loss of sample subjects—lowered power and increased Type II error—and the potential of capitalizing on chance alone—the possibility that the previously significant results were in fact the result of Type I error. The analysis also shows that the attrition rates due to attention checks—upwards of 70% in some observed samples—are far larger than typically assumed. Such loss rates raise the specter that studies not validating attention may inadvertently increase their Type I error rate. The manuscript provides general guidelines for various attention checks, discusses the psychological nuances of the methods, and highlights the delicate balance among incentive alignment, monetary compensation, and the subsequently triggered mood of respondents.
The Battle for the Catholic Past in Germany, 1945–1980
Authors: Ruff Mark Edward
Published: July 2017

Were Pope Pius XII and the Catholic Church in Germany unduly singled out after 1945 for their conduct during the National Socialist era? Mark Edward Ruff explores the bitter controversies that broke out in the Federal Republic of Germany from 1945 to 1980 over the Catholic Church's relationship to the Nazis. He explores why these cultural wars consumed such energy, dominated headlines, triggered lawsuits and required the intervention of foreign ministries. He argues that the controversies over the church's relationship to National Socialism were frequently surrogates for conflicts over how the church was to position itself in modern society - in politics, international relations and the media. More often than not, these exchanges centered on problems perceived as arising from the postwar political ascendancy of Roman Catholics and the integration of Catholic citizens into the societal mainstream.
Family Foster Care: Let's Not Throw the Baby Out with the Bathwater
Authors: McSherry Dominic , Fargas Malet Montserrat
Published: July 2017

In 2014, an article written by Dr Frank Ainsworth and Patricia Hansen was published in Children Australia entitled ‘Family foster care: Can it survive the evidence?’ The basic premise of the article was that evidence indicates family foster care either doesn't change the likelihood of positive outcomes for children, or makes it more difficult for positive outcomes to be achieved. Essentially, the view was that foster care is a risk to children in much the same way as there is a risk for children remaining at home with abusive or neglectful parents. As such, the authors stated that there should be a reduction in the use of family foster care, and increased efforts to keep children at home with supports. This article only came to our attention recently, and we had some issues with the conclusions that were drawn by the authors, particularly in terms of the evidence that is used to support their proposition. We were kindly offered an opportunity by the journal editors to submit this responding article.
Stability of three-dimensional Gaussian vortices in an unbounded, rotating, vertically stratified, Boussinesq flow: linear analysis
Authors: Mahdinia Mani , Hassanzadeh Pedram , Marcus Philip S. , Jiang Chung-Hsiang
Published: July 2017

The linear stability of three-dimensional vortices in rotating, stratified flows has been studied by analysing the non-hydrostatic inviscid Boussinesq equations. We have focused on a widely used model of geophysical and astrophysical vortices, which assumes an axisymmetric Gaussian structure for pressure anomalies in the horizontal and vertical directions. For a range of Rossby numbers ($-0.5<Ro<0.5$) and Burger numbers ($0.02<Bu<2.3$) relevant to observed long-lived vortices, the growth rate and spatial structure of the most unstable eigenmodes have been numerically calculated and presented as a function of $Ro{-}Bu$. We have found neutrally stable vortices only over a small region of the $Ro{-}Bu$ parameter space: cyclones with $Ro\sim 0.02{-}0.05$ and $Bu\sim 0.85{-}0.95$. However, we have also found that anticyclones in general have slower growth rates compared to cyclones. In particular, the growth rate of the most unstable eigenmode for anticyclones in a large region of the parameter space (e.g. $Ro<0$ and $0.5\lesssim Bu\lesssim 1.3$) is slower than 50 turnaround times of the vortex (which often corresponds to several years for ocean eddies). For cyclones, the region with such slow growth rates is confined to $0<Ro<0.1$ and $0.5\lesssim Bu\lesssim 1.3$. While most calculations have been done for $f/\bar{N}=0.1$ (where $f$ and $\bar{N}$ are the Coriolis and background Brunt–Väisälä frequencies), we have numerically verified and explained analytically, using non-dimensionalized equations, the insensitivity of the results to reducing $f/\bar{N}$ to the more ocean-relevant value of 0.01. The results of our stability analysis of Gaussian vortices both support and contradict the findings of earlier studies with QG or multilayer models or with other families of vortices. The results of this paper provide a stepping stone to study the more complicated problems of the stability of geophysical (e.g. those in the atmospheres of giant planets) and astrophysical vortices (in accretion disks).
Statistics and tensor analysis of polymer coil–stretch mechanism in turbulent drag reducing channel flow
Authors: Pereira Anselmo S. , Mompean Gilmar , Thais Laurent , Thompson Roney L.
Published: July 2017

The polymer coil–stretch mechanism in turbulent drag reducing flows is analysed using direct numerical simulations of viscoelastic finitely extensible nonlinear elastic fluids with the Peterlin approximation. The study is carried out taking into account low and high drag reduction regimes. The polymer stretching and the alignment between the conformation tensor and other relevant entities are investigated using statistical and tensor analysis. The significant alignment between the former and the velocity fluctuations product tensor indicates that the initial polymer stretching due to the mean shear is increased by the flow stress fluctuations, providing a supplementary polymer extension. In addition, interactions between the turbulence and the polymer are evaluated from an instantaneous turbulent energy exchange perspective by considering streamwise work fluctuating terms in elliptical and hyperbolic flow regions separately. Near the wall, polymers not only release energy to the streaks, but also to the elliptical (or vortical) and hyperbolic (or extensional) structures. However, polymers can also be dragged around near-wall vortices, passing through hyperbolic regions and experiencing a significant straining within both these turbulent structures and storing their energy. Hence, polymers weaken elliptical and hyperbolic structures leading to a tendency toward relaminarization of the flow. Polymer release of energy occurs primarily in the streamwise direction, which is in agreement with the enhanced streamwise velocity fluctuation observed in drag reducing flows. A detailed polymer coil–stretch mechanism is provided.
Unsteady flow dynamics reconstruction from mean flow and point sensors: an experimental study
Authors: Beneddine Samir , Yegavian Robin , Sipp Denis , Leclaire Benjamin
Published: July 2017

This article presents a reconstruction of the unsteady behaviour of a round jet at a Reynolds number equal to 3300, from the sole knowledge of the time-averaged flow field and one pointwise unsteady measurement. The reconstruction approach is an application of the work of Beneddine et al. (J. Fluid Mech., vol. 798, 2016, pp. 485–504) and relies on the computation of the dominant resolvent modes of the flow, using a parabolised stability equations analysis. To validate the procedure, the unsteady velocity field of the jet has been characterised by time-resolved particle image velocimetry (TR-PIV), yielding an experimental reference. We first show that the dominant resolvent modes are proportional to the experimental Fourier modes, as predicted by Beneddine et al. (J. Fluid Mech., vol. 798, 2016, pp. 485–504). From these results, it is then possible to fully reconstruct the unsteady velocity and pressure fluctuation fields, yielding a flow field that displays good agreement with the experimental reference. Finally, it is found that the robustness of the reconstruction mainly depends on the location of the pointwise unsteady measurement, which should be within energetic regions of the flow, and this robustness as well as the quality of the reconstruction can be greatly improved by considering a few pointwise measurements instead of a single one. The effects of other experimental parameters on the reconstruction, such as the size of the interrogation window used for the TR-PIV processing and the accuracy of the positioning of the sensors, are also investigated in this paper.
Experimental characterisation of the screech feedback loop in underexpanded round jets
Authors: Mercier Bertrand , Castelain Thomas , Bailly Christophe
Published: July 2017

Near-field acoustic measurements and time-resolved schlieren visualisations are performed on 10 round jets with the aim of analysing the different parts of the feedback loop related to the screech phenomenon in a systematic fashion. The ideally expanded Mach number of the studied jets ranges from$M_{j}=1.07$to$M_{j}=1.50$. The single source of screech acoustic waves is found at the fourth shock tip for A1 and A2 modes, and at either the third or the fourth shock tip for the B mode, depending on the Mach number. The phase of the screech cycle is measured throughout schlieren visualisations in the shear layer from the nozzle to the source. Estimates of the convective velocities are deduced for each case, and a trend for the convective velocity to grow with the axial distance is pointed out. These results are used together with source localisation deduced from a two-microphone survey to determine the number of screech periods contained in a screech loop. For the A1 and B modes, four periods are contained in a loop for cases in which the radiating shock is the fourth, and three periods when the radiating shock tip is the third, whereas the loop of the A2 mode contains five periods.
Active control of transonic buffet flow
Authors: Gao Chuanqiang , Zhang Weiwei , Kou Jiaqing , Liu Yilang , Ye Zhengyin
Published: July 2017

Transonic buffet is a phenomenon of aerodynamic instability with shock wave motions which occurs at certain combinations of Mach number and mean angle of attack, and which limits the aircraft flight envelope. The objective of this study is to develop a modelling method for unstable flow with oscillating shock waves and moving boundaries, and to perform model-based feedback control of the two-dimensional buffet flow by means of trailing-edge flap oscillations. System identification based on the ARX algorithm is first used to derive a linear model of the input–output dynamics between the flap rotation (the control input) and the lift and pitching moment coefficients (system outputs). The model features a pair of unstable complex-conjugate poles at the characteristic buffet frequency. An appropriate reduced-order model (ROM) with a lower dimension is further obtained by a balanced truncation method that keeps the pair of unstable poles in the unstable subspace but truncates the dynamics in the stable subspace. Based on this balanced ROM, two kinds of feedback control are designed by pole assignment and linear quadratic methods respectively. These independent designs, however, result in similar suboptimal static output feedback control laws. When introduced in numerical simulations, they are both able to completely suppress the buffet instability. Furthermore, the resulting controllers are even able to stabilize buffet flows with nonlinear disturbances and in off-design flow conditions, thus implying their robustness. The analysis of the feedback control laws indicates that parameters (frequency and phase) corresponding to the ‘anti-resonance’ of the linear input–output model are vital for optimal control. The best performance is obtained when the control operates close to the ‘anti-resonance’, which is supported by the optimal frequency and the phase of the open-loop control as well as by the optimal phase of the closed-loop control.
The role of team reflexivity as a mediator between project management skills, task familiarity, procedural justice, and product performance
Authors: Wu Wann-Yih , Amaya Rivas Adriana , Chen Yen-Chun
Published: July 2017

Even though the importance of team reflexivity in new product development (NPD) has been well noted in the literature, little attention has been paid to its determinants. Based on the resource-based view, this study proposes that project management skills, task familiarity, and procedural justice are useful to improve team reflexivity. As such, this study also examines the influences that these antecedents and team reflexivity have on NPD. A research framework is proposed along with 10 major hypotheses. To test these, data were collected from 186 team members from NPD teams in Taiwanese high-tech firms, and the partial least square results of confirm that all three of the proposed antecedents have direct impacts on team reflexivity and NPD performance. Task familiarity had the highest mediation effect on the influence of project management skills on NPD performance, followed by team reflexivity and procedural justice. Since previous studies largely ignored the effects of antecedents on team reflexivity and NPD performance, this study provides useful insights for both academics and practitioners.
Organizational Imprinting and Response to Institutional Complexity: Evidence from Publicly-Traded Chinese State-Owned Firms in Hong Kong
Authors: Wei Yifan
Published: July 2017

This study seeks to answer the following question: What are the organizational attributes that influence organizational responses to institutional complexity? Building on core ideas of organizational imprinting, I argue that organizational response is influenced by the imprint from the dominant logic of organizing during the founding period and from the institutional position an organization possessed at founding. Empirically, I examine the variation in board composition of Chinese state-owned firms listed in the Hong Kong Stock Exchange market. It is found that state-owned firms founded in the market logic dominant period tend to have more non-state directors on the board in that they were organized around the prescription of the market logic and more responsive to shareholders’ demands for legitimacy reasons. Besides, state-owned firms founded by central government agencies tend to have fewer non-state directors because they were born at the center of the socialist system to accomplish strategic goals of the central government and non-state directors may challenge the vested interests. This study contributes to the organizational imprinting and institutional literature and resonates with the contemporary call for a more systematic examination of organizational attributes that influence organizational responses to institutional complexity.
Management and Organization Review Special Issue ‘Doing Qualitative Research in Emerging Markets’
Authors: Plakoyiannaki Emmanuella , Wei Tian , Hsu Carol , Cassell Catherine , Prashantham Shameen
Published: July 2017

The Management and Organization Review (MOR) special issue on ‘Doing Qualitative Research in Emerging Markets’ aims to advance the quality, diversity, and understanding of qualitative research methods in management in the context of emerging markets. The value of qualitative research is increasingly embraced by management scholars thanks to its merits for building new theories and testing existing ones, as well as exemplifying new phenomena by surfacing contextual idiosyncrasies (Bansal & Corley, 2011; Birkinshaw, Brannen, & Tang, 2011; Eisenhardt & Graebner, 2007; Rynes, 2007; Welch, Piekkari, Plakoyiannaki, & Paavilainen-Mantymaki, 2011). As Bansal and Corley (2011: 234) suggest ‘The beauty of qualitative research is that it accommodates different paradigms and different styles of research and research reporting. Although there are merits to having norms emerge for the style of qualitative research manuscripts, we do not want to stifle creativity’.
Observing Pulsars with a Phased Array Feed at the Parkes Telescope
Authors: Deng X. , Chippendale A. P. , Hobbs G. , Johnston S. , Dai S. , George D. , Kramer M. , Karuppusamy R. , Malenta M. , Spitler L. , Tzioumis T. , Wieching G.
Published: July 2017

During 2016 February, CSIRO Astronomy and Space Science and the Max-Planck-Institute for Radio Astronomy installed, commissioned, and carried out science observations with a phased array feed receiver system on the 64-m diameter Parkes radio telescope. Here, we demonstrate that the phased array feed can be used for pulsar observations and we highlight some unique capabilities. We demonstrate that the pulse profiles obtained using the phased array feed can be calibrated and that multiple pulsars can be simultaneously observed. Significantly, we find that an intrinsic polarisation leakage of −31 dB can be achieved with a phased array feed beam offset from the centre of the field of view. We discuss the possibilities for using a phased array feed for future pulsar observations and for searching for fast radio bursts with the Parkes and Effelsberg telescopes.
ON POLYNOMIALS WHOSE ROOTS HAVE RATIONAL QUOTIENT OF DIFFERENCES
Authors: LUCA FLORIAN
Published: July 2017

We classify all polynomials$P(X)\in \mathbb{Q}[X]$with rational coefficients having the property that the quotient$(\unicode[STIX]{x1D706}_{i}-\unicode[STIX]{x1D706}_{j})/(\unicode[STIX]{x1D706}_{k}-\unicode[STIX]{x1D706}_{\ell })$is a rational number for all quadruples of roots$(\unicode[STIX]{x1D706}_{i},\unicode[STIX]{x1D706}_{j},\unicode[STIX]{x1D706}_{k},\unicode[STIX]{x1D706}_{\ell })$with$\unicode[STIX]{x1D706}_{k}\neq \unicode[STIX]{x1D706}_{\ell }$.
Ames, Ramus, and the Method of Puritan Theology
Authors: Sprunger Keith L.
Published: July 2017

Theology, as many Puritans saw it, was a combination of sound doctrine, practical exhortation, and precise method. The Marrow of Sacred Divinity by William Ames, a great favorite in many seventeenth-century Puritan homes, owed much of its reputation to a blend of these ingredients of doctrine, practical divinity, and method. Although Puritan theologians wrote few systematic theologies except for creeds and catechisms, the Marrow is one example of theology from a scholarly Puritan perspective. The writings of Ames with their Congregational theories were most at home in Congregational New England, perhaps, but Puritans in England also read and studied Ames. William Ames, 1576–1633, was born in East Anglia and educated at Christ's College, Cambridge; but he lived for over twenty years in the Netherlands as a religious exile. Like his life, his theology combines English nonconformity and Continental Calvinism.
ASSOCIATION OF AGE AT MENOPAUSE WITH POST-MENOPAUSAL SYMPTOMS, MENARCHE AGE AND OTHER REPRODUCTIVE FACTORS AMONG RURAL FEMALES IN SHIMLA, HIMACHAL PRADESH
Authors: Sharma Krishan , Bansal Mayuk
Published: July 2017

This study analysed the association between menopause, menarche and number of live births using cross-sectional primary data for 75 post-menopausal rural women from Shimla in the Indian state of Himachal Pradesh. The mean/median ages at menarche of the 75 women were 14.23/14 years, and those at menopause 45.35/45 years. There were no significant differences in these values between women in the age groups 40–55 and 56–65 years. Age at menopause was found to be significantly associated with age at menarche and maternal age at birth of the first and last child, but not with menopausal symptom severity score. The majority of the 75 post-menopausal women (70.7%) had very mild or no menopausal symptoms. Three principal components were identified that explained 72.43% of the underlying variation in menopausal symptoms.
FUNERARY TRANSFORMATIONS IN AN ETRUSCO-ITALIC COMMUNITY: SOCIAL DISPLAY AND AUSTERITY IN HELLENISTIC CHIUSI
Authors: Daveloose Alexis
Published: July 2017

From the end of the third century BC on, the funerary culture of the Etruscan city of Chiusi saw the gradual disappearance of the most expensive containers and tombs. At the same time, there was first a dramatic increase in the number of such monuments, followed by an equally sharp decline in the first century BC. The qualitative development has traditionally been explained using sumptuary laws, which should have constrained funerary expenditure. However, a close examination of the local evidence reveals that this is not only unlikely, but also does not explain the quantitative development and why there was a social and cultural need to constrain these funerary objects in the first place. Using the concepts of distinction and habitus developed by Bourdieu, this paper analyses the developments in Chiusine funerary practice by focusing on social interactions within and between élites and non-élites. This gives both groups agency in a complex social, cultural and political process that caused the criteria for distinction to change, ultimately making funerary culture less important for status differentiation in the rapidly changing context of Hellenistic Italy.
Finite speed of propagation and waiting time for a thin-film Muskat problem
Authors: Laurençot Philippe , Matioc Bogdan-Vasile
Published: July 2017

Propagation at a finite speed is established for non-negative weak solutions to a thin-film approximation of the two-phase Muskat problem. The expansion rate of the support matches the scale invariance of the system. Moreover, we determine sufficient conditions on the initial data for the occurrence of waiting time phenomena.
Seroepidemiology ofToxoplasma gondiiinfection in patients with liver disease in eastern China
Authors: TIAN A. L. , LI G. X. , ELSHEIKHA H. M. , GARDNER D. S. , ZHANG X. Y. , DONG W. , YANG X. P. , LUO Y. Y. , LI H. L. , CONG W. , ZHU X. Q.
Published: July 2017

The role of the protozoan parasiteToxoplasma gondiiin the pathogenesis of liver disease has recently gained much interest. The aim of this study was to determine the prevalence and risk factors associated withT. gondiiinfection in patients with liver disease from three cities in Shandong and Henan provinces, China. A case–control study was conducted from December 2014 to November 2015 and included 1142 patients with liver disease and 1142 healthy controls. Serum samples were collected from all individuals and were examined with enzyme-linked immunosorbent assay for the presence of anti-T. gondiiIgG and IgM antibodies. Information on the demographics, clinical, and lifestyle characteristics of the participants was collected from the medical records and by the use of a questionnaire. The prevalence of anti-T. gondiiIgG was 19·7% in patients with liver disease compared with 12·17% in the controls. Only 13 patients had anti-T. gondiiIgM antibodies compared with 12 control individuals (1·14%vs.1·05%, respectively). The highest seroprevalence was detected in patients with liver cancer (22·13%), followed by hepatitis patients (20·86%), liver cirrhosis patients (20·42%), and steatosis patients (20%). Multivariate logistic regression analysis indicated that consumption of raw meat (odds ratio (OR) = 1·32; 95% confidence interval (CI) 1·01–1·71;P= 0·03) and source of drinking water from wells (OR = 1·56; 95% CI 1·08–2·27;P= 0·01) were independent risk factors forT. gondiiinfection in liver disease patients. These findings indicate thatT. gondiiinfection is more likely to be present in patients with liver disease. Therefore, efforts should be directed toward health education of populations at high risk ofT. gondiiinfection and measures should be taken to protect vulnerable patients with liver disease.
De Consolatione Philosophiae
Authors: Haldane John
Published: July 2017

While I was quietly thinking these thoughts [about misfortune] over to myself and giving vent to my sorrow with the help of my pen, I became aware of a woman standing over me. She was of aweinspiring appearance, her eyes burning and keen beyond the usual power of men. She was so full of years that I could hardly think of her as of my own generation, and yet she possessed a vivid colour and undiminished vigour … Her clothes were made of imperishable material, of the finest thread woven with the most delicate skill … On the bottom hem could be read the embroidered Greek letter Pi, and on the top hem the Greek letter Theta. Between the two a ladder of steps rose from the lower to the higher letter. Her dress had been torn by the hands of marauders who had each carried off such pieces as he could get. There were some books in her right hand and in her left hand she held a sceptre … As she spoke she gathered her dress into a fold and wiped from my eyes the tears that filled them … the clouds of my grief dissolved and I drank in the light.
Descartes' Debt to Augustine
Authors: Clark Stephen R. L.
Published: July 2017

Jonathan Edwards identified the central act of faith as ‘the cordial consent of beings to Being in general’, which is to say to God (see Holbrook, 1973, pp. 102ff). That equation, of Being, Truth and God, is rarely taken seriously in analytical circles. My argument will be that this is to neglect the real context of a great deal of past philosophy, particularly the very Cartesian arguments from which so many undergraduate courses begin. All too many students issue from such courses immunized against enthusiasm, in the conceit that they have answers to all the old conundrums, which were in any case no more than verbal trickery. ‘By uttering the right words but failing to use themin propria persona, philosophy induces a kind of soporific amnesia bewitching us into forgetting our God-given task. That task is, of course, to do what Socrates did and to live as he lived' (Burrell, 1972, p. 4). Burrell's words are not wholly fair to academic philosophers, nor to the Lady Philosophy. Plenty of philosophers really mind about the truth, and want to be Socratic in pursuit of it. But the danger is a real one. If all that matters is debunking past philosophers, how does that differ from the repeated refutation of the Chaldaean Oracles or the Prophecies of Nostradamus? A pretty enough pastime for the young, but hardly serious business for adults (as Callicles remarks: Plato,Gorgias484 c 5ff). ‘If the history of philosophy is a process of ‘salvaging’ what you yourself have already thought, then why bother?’ (MacDonald Ross, 1985, p. 502).
Infant and young child feeding patterns in Kuwait: results of a cross-sectional survey
Authors: Carballo Manuel , Khatoon Noureen , Maclean Elizabeth Catherine , Al-Hamad Nawal , Mohammad Anwar , Al-Wotayan Rehab , Abraham Smitha
Published: July 2017

Objective

The beneficial role of breast-feeding for maternal and child health is now well established. Its possible role in helping to prevent diabetes and obesity in children in later life means that more attention must be given to understanding how patterns of infant feeding are changing. The present study describes breast-feeding profiles and associated factors in Kuwait.

Design/Setting/Subjects

Interviews with 1484 recent mothers were undertaken at immunisation clinics across Kuwait. Descriptive analysis and binary logistic regression of results were performed.

Results

Rates of breast-feeding initiation in Kuwait were high (98·1 %) but by the time of discharge from hospital, only 36·5 % of mothers were fully breast-feeding, 37·0 % were partially breast-feeding and 26·5 % were already fully formula-feeding. Multiple social and health reasons were given for weaning the child, with 87·6 % of mothers who had stopped breast-feeding completely doing so within 3 months postpartum. Nationality (P<0·001), employment status 6 months prior to delivery (P<0·001), mode of delivery (P=0·01), sex of the child (P=0·026) and breast-feeding information given by nurses (P=0·026) were all found to be significantly associated with breast-feeding. Few women (5·6 %) got information on infant nutrition and feeding from nursing staff, but those who did were 2·54 times more likely to be still breast-feeding at discharge from hospital. Over 70 % of mothers had enjoyed breast-feeding and 74 % said they would be very likely to breast-feed again.

Conclusions

In Kuwait where the prevalence of both obesity and type 2 diabetes is growing rapidly, the public health role of breast-feeding must be recognised and acted upon more than it has in the past.
Comparative Analysis of 2,4-D Uptake, Translocation, and Metabolism in Non–AAD-1 Transformed and 2,4-D–Resistant Corn
Authors: Skelton Joshua J. , Simpson David M. , Peterson Mark A. , Riechers Dean E.
Published: July 2017

The Enlist™ traits provide 2,4-D resistance in several crops. Though corn is naturally tolerant to 2,4-D, the engineered trait conferred by the aryloxyalkanoate dioxygenase-1 (AAD-1) enzyme provides enhanced 2,4-D tolerance and confers resistance to the graminicide herbicide family, the aryloxyphenoxypropionates. The objectives of this research were 2-fold: (1) measure and compare uptake, translocation, and metabolism of 2,4-D in Enlist™ (E, +AAD1) and non–AAD-1 transformed (NT, −AAD1) isogenic corn hybrids; and (2) and investigate the effect of glyphosate and/or the Enlist™ adjuvant system (ADJ) on these factors and corn injury. Uptake of radiolabeled 2,4-D acid applied alone in corn was not altered by the addition of ADJ when tank mixed at 24 h after application (HAA). By contrast, uptake of radiolabeled 2,4-D was significantly lower (69%) compared with 2,4-D plus ADJ (89%) at 24 HAA with a premixed formulation of 2,4-D choline plus glyphosate-dimethylamine (Enlist Duo™ herbicide [EDH]). Translocation of 2,4-D between the two corn hybrids was not different. E corn metabolized more 2,4-D (100% of absorbed) than NT corn (84%), and glyphosate did not alter 2,4-D metabolism. Furthermore, the metabolism of 2,4-D to nonphytotoxic dichlorophenol (DCP) and subsequent DCP-derived metabolites formed in E corn was examined. Injury to E corn is not typically observed in the field; however, injury symptoms were clearly evident in E corn (within 24 HAA) when formulated acetochlor was tank mixed with EDH, which correlated with an increase in 2,4-D uptake during this time period. In summary, the lack of injury in E corn following EDH applied alone may be attributed to a relatively low amount of 2,4-D uptake and the combination of natural and engineered 2,4-D metabolic pathways.
Ballistic edge states in Bismuth nanowires revealed by SQUID interferometry
Authors: Murani Anil , Kasumov Alik , Sengupta Shamashis , Kasumov Yu A. , Volkov V. T. , Khodos I. I. , Brisset F. , Delagrange Raphaëlle , Chepelianskii Alexei , Deblock Richard , Bouchiat Hélène , Guéron Sophie
Published: July 2017

The protection against backscattering provided by topology is a striking property. In two-dimensional insulators, a consequence of this topological protection is the ballistic nature of the one-dimensional helical edge states. One demonstration of ballisticity is the quantized Hall conductance. Here we provide another demonstration of ballistic transport, in the way the edge states carry a supercurrent. The system we have investigated is a micrometre-long monocrystalline bismuth nanowire with topological surfaces, that we connect to two superconducting electrodes. We have measured the relation between the Josephson current flowing through the nanowire and the superconducting phase difference at its ends, the current–phase relation. The sharp sawtooth-shaped phase-modulated current–phase relation we find demonstrates that transport occurs selectively along two ballistic edges of the nanowire. In addition, we show that a magnetic field induces 0–π transitions and ϕ0-junction behaviour, providing a way to manipulate the phase of the supercurrent-carrying edge states and generate spin supercurrents.
MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain
Authors: Sakai Atsushi , Saitow Fumihito , Maruyama Motoyo , Miyake Noriko , Miyake Koichi , Shimada Takashi , Okada Takashi , Suzuki Hidenori
Published: July 2017

miR-17-92 is a microRNA cluster with six distinct members. Here, we show that the miR-17-92 cluster and its individual members modulate chronic neuropathic pain. All cluster members are persistently upregulated in primary sensory neurons after nerve injury. Overexpression of miR-18a, miR-19a, miR-19b and miR-92a cluster members elicits mechanical allodynia in rats, while their blockade alleviates mechanical allodynia in a rat model of neuropathic pain. Plausible targets for the miR-17-92 cluster include genes encoding numerous voltage-gated potassium channels and their modulatory subunits. Single-cell analysis reveals extensive co-expression of miR-17-92 cluster and its predicted targets in primary sensory neurons. miR-17-92 downregulates the expression of potassium channels, and reduced outward potassium currents, in particular A-type currents. Combined application of potassium channel modulators synergistically alleviates mechanical allodynia induced by nerve injury or miR-17-92 overexpression. miR-17-92 cluster appears to cooperatively regulate the function of multiple voltage-gated potassium channel subunits, perpetuating mechanical allodynia.
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
Authors: To Eunice E. , Vlahos Ross , Luong Raymond , Halls Michelle L. , Reading Patrick C. , King Paul T. , Chan Christopher , Drummond Grant R. , Sobey Christopher G. , Broughton Brad R. S. , Starkey Malcolm R. , van der Sluis Renee , Lewin Sharon R. , Bozinovski Steven , O’Neill Luke A. J. , Quach Tim , Porter Christopher J. H. , Brooks Doug A. , O’Leary John J. , Selemidis Stavros
Published: July 2017

The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting strain. Reactive oxygen species are ancient processes that protect plants, fungi and animals against invading pathogens including bacteria. However, in mammals reactive oxygen species production paradoxically promotes virus pathogenicity by mechanisms not yet defined. Here we identify that the primary enzymatic source of reactive oxygen species, NOX2 oxidase, is activated by single stranded RNA and DNA viruses in endocytic compartments resulting in endosomal hydrogen peroxide generation, which suppresses antiviral and humoral signaling networks via modification of a unique, highly conserved cysteine residue (Cys98) on Toll-like receptor-7. Accordingly, targeted inhibition of endosomal reactive oxygen species production abrogates influenza A virus pathogenicity. We conclude that endosomal reactive oxygen species promote fundamental molecular mechanisms of viral pathogenicity, and the specific targeting of this pathogenic process with endosomal-targeted reactive oxygen species inhibitors has implications for the treatment of viral disease.
A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis
Authors: López-Mejías Raquel , Carmona F. David , Castañeda Santos , Genre Fernanda , Remuzgo-Martínez Sara , Sevilla-Perez Belén , Ortego-Centeno Norberto , Llorca Javier , Ubilla Begoña , Mijares Verónica , Pina Trinitario , Miranda-Filloy José A. , Navas Parejo Antonio , de Argila Diego , Aragües Maximiliano , Rubio Esteban , Luque Manuel León , Blanco-Madrigal Juan María , Galíndez-Aguirregoikoa Eva , Jayne David , Blanco Ricardo , Martín Javier , González-Gay Miguel A.
Published: July 2017

The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS) on this condition. 308 IgA vasculitis patients and 1,018 healthy controls from Spain were genotyped by Illumina HumanCore BeadChips. Imputation of GWAS data was performed using the 1000 Genomes Project Phase III dataset as reference panel. After quality control filters and GWAS imputation, 285 patients and 1,006 controls remained in the datasets and were included in further analysis. Additionally, the human leukocyte antigen (HLA) region was comprehensively studied by imputing classical alleles and polymorphic amino acid positions. A linkage disequilibrium block of polymorphisms located in the HLA class II region surpassed the genome-wide level of significance (OR = 0.56, 95% CI = 0.46–0.68). Although no polymorphic amino acid positions were associated at the genome-wide level of significance, P-values of potential relevance were observed for the positions 13 and 11 of HLA-DRB1 (P = 6.67E-05, P = 1.88E-05, respectively). Outside the HLA, potential associations were detected, but none of them were close to the statistical significance. In conclusion, our study suggests that IgA vasculitis is an archetypal HLA class II disease.
A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity
Authors: Xu Jian , Wang Ju-xian , Zhou Jin-ming , Xu Chang-liang , Huang Bin , Xing Yun , Wang Bin , Luo Rui , Wang Yu-cheng , You Xue-fu , Lu Yu , Yu Li-yan
Published: July 2017

Protein kinase B (PknB) is one of the Mycobacterium tuberculosis serine/threonine protein kinases and has an essential role in sustaining mycobacterial growth. Here, we identified and characterized a novel small molecule compound named IMB-YH-8 that inhibited PknB and served as anti-mycobacteria lead compound. IMB-YH-8 inhibited PknB auto-phosphorylation and the phosphorylation of GarA by PknB in a dose-dependent manner. The compound did not inhibit human Akt1 or other serine/threonine kinases in M. tuberculosis except for the highly homologous PknA. IMB-YH-8 bound to PknB with a moderate affinity. Molecular docking revealed that IMB-YH-8 interacts with the catalytic domain of PknB. Observations of electron microscopy showed that IMB-YH-8 changed the morphology of H37Rv and disrupted the cell wall. The differential transcriptional response of M. tuberculosis to IMB-YH-8 revealed changes in SigH regulatory pathways modulated by PknB. Notably IMB-YH-8 not only potently inhibited drug-sensitive and multidrug-resistant clinical isolates but also exhibited a dose dependent inhibition of intracellular M. tuberculosis. Taken together, these in vitro data demonstrate that IMB-YH-8 is a novel inhibitor of PknB, which potently prevents growth of M. tuberculosis. It is as yet unclear whether inhibition of PknA contributes to the anti-tubercular action of IMB-YH-8.
The genetic architecture of water-soluble protein content and its genetic relationship to total protein content in soybean
Authors: Zhang Dan , Lü Haiyan , Chu Shanshan , Zhang Huairen , Zhang Hengyou , Yang Yuming , Li Hongyan , Yu Deyue
Published: July 2017

Water-soluble protein content (WSPC) is a critical factor in both soybean protein quality and functionality. However, the underlying genetic determinants are unclear. Here, we used 219 soybean accessions and 152 recombinant inbred lines genotyped with high-density markers and phenotyped in multi-environments to dissect the genetic architectures of WSPC and protein content (PC) using single- and multi-locus genome-wide association studies. In the result, a total of 32 significant loci, including 10 novel loci, significantly associated with WSPC and PC across multi-environments were identified, which were subsequently validated by linkage mapping. Among these loci, only four exhibited pleiotropic effects for PC and WSPC, explaining the low correlation coefficient between the two traits. The largest-effect WSPC-specific loci, GqWSPC8, was stably identified across all six environments and tagged to a linkage disequilibrium block comprising two promising candidate genes AAP8 and 2 S albumin, which might contribute to the high level of WSPC in some soybean varieties. In addition, two genes, Glyma.13G123500 and Glyma.13G194400 with relatively high expression levels at seed development stage compared with other tissues were regarded as promising candidates associated with the PC and WSPC, respectively. Our results provide new insights into the genetic basis of WSPC affecting soybean protein quality and yield.
Influence of the Body Schema on Multisensory Integration: Evidence from the Mirror Box Illusion
Authors: Liu Yuqi , Medina Jared
Published: July 2017

When placing one hand on each side of a mirror and making synchronous bimanual movements, the mirror-reflected hand feels like one’s own hand that is hidden behind the mirror. We developed a novel mirror box illusion to investigate whether motoric, but not spatial, visuomotor congruence is sufficient for inducing multisensory integration, and importantly, if biomechanical constraints encoded in the body schema influence multisensory integration. Participants placed their hands in a mirror box in opposite postures (palm up, palm down), creating a conflict between visual and proprioceptive feedback for the hand behind the mirror. After synchronous bimanual hand movements in which the viewed and felt movements were motorically congruent but spatially in the opposite direction, participants felt that the hand behind the mirror rotated or completely flipped towards matching the hand reflection (illusory displacement), indicating facilitation of multisensory integration by motoric visuomotor congruence alone. Some wrist rotations are more difficult due to biomechanical constraints. We predicted that these biomechanical constraints would influence illusion effectiveness, even though the illusion does not involve actual limb movement. As predicted, illusory displacement increased as biomechanical constraints and angular disparity decreased, providing evidence that biomechanical constraints are processed in multisensory integration.
Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: evidence for memory flexibility in young adults
Authors: Suwabe Kazuya , Hyodo Kazuki , Byun Kyeongho , Ochi Genta , Fukuie Takemune , Shimizu Takeshi , Kato Morimasa , Yassa Michael A. , Soya Hideaki
Published: July 2017

A physically active lifestyle has beneficial effects on hippocampal memory function. A potential mechanism for this effect is exercise-enhanced hippocampal plasticity, particularly in the dentate gyrus (DG). Within hippocampal memory formation, the DG plays a crucial role in pattern separation, which is the ability to discriminate among similar experiences. Computational models propose a theoretical hypothesis that enhanced DG-mediated pattern separation leads to “memory flexibility”–a selective improvement in the ability to overcome moderate levels of mnemonic interference. Thus, in the current cross-sectional study of healthy young adults, we tested the working hypothesis that aerobic fitness, as a physiological indicator of endurance capacity associated with physical activity, is strongly associated with mnemonic discrimination at moderate interference levels. When divided the sample (n = 75) based on a median split of aerobic fitness, the higher fitness group had better discrimination performance for moderate interference levels compared to the lower fitness group, namely, exhibited memory flexibility. Moreover, aerobic fitness levels were positively associated with discrimination performance for moderate interference levels, as a mediator of physical activity effects. This evidence suggests that aerobic fitness levels are associated with hippocampal DG-related memory, which is consistent with literature showing positive effect of physical exercise on hippocampal memory.