bluuebunny/crossref_metadata_2025 huggingface dataset:
A high diversity of mechanisms endows ALS-inhibiting herbicide resistance in the invasive common ragweed (Ambrosia artemisiifolia L.)
Authors: Loubet Ingvild , Caddoux Laëtitia , Fontaine Séverine , Michel Séverine , Pernin Fanny , Barrès Benoit , Le Corre Valérie , Délye Christophe
Published: October 2021

Ambrosia artemisiifolia L. (common ragweed) is a globally invasive, allergenic, troublesome arable weed. ALS-inhibiting herbicides are broadly used in Europe to control ragweed in agricultural fields. Recently, ineffective treatments were reported in France. Target site resistance (TSR), the only resistance mechanism described so far for ragweed, was sought using high-throughput genotyping-by-sequencing in 213 field populations randomly sampled based on ragweed presence. Additionally, non-target site resistance (NTSR) was sought and its prevalence compared with that of TSR in 43 additional field populations where ALS inhibitor failure was reported, using herbicide sensitivity bioassay coupled with ALS gene Sanger sequencing. Resistance was identified in 46 populations and multiple, independent resistance evolution demonstrated across France. We revealed an unsuspected diversity of ALS alleles underlying resistance (9 amino-acid substitutions involved in TSR detected across 24 populations). Remarkably, NTSR was ragweed major type of resistance to ALS inhibitors. NTSR was present in 70.5% of the resistant plants and 74.1% of the fields harbouring resistance. A variety of NTSR mechanisms endowing different resistance patterns evolved across populations. Our study provides novel data on ragweed resistance to herbicides, and emphasises that local resistance management is as important as mitigating gene flow from populations where resistance has arisen.
Inverse problems for structured datasets using parallel TAP equations and restricted Boltzmann machines
Authors: Decelle Aurelien , Hwang Sungmin , Rocchi Jacopo , Tantari Daniele
Published: October 2021

We propose an efficient algorithm to solve inverse problems in the presence of binary clustered datasets. We consider the paradigmatic Hopfield model in a teacher student scenario, where this situation is found in the retrieval phase. This problem has been widely analyzed through various methods such as mean-field approaches or the pseudo-likelihood optimization. Our approach is based on the estimation of the posterior using the Thouless–Anderson–Palmer (TAP) equations in a parallel updating scheme. Unlike other methods, it allows to retrieve the original patterns of the teacher dataset and thanks to the parallel update it can be applied to large system sizes. We tackle the same problem using a restricted Boltzmann machine (RBM) and discuss analogies and differences between our algorithm and RBM learning.
A multicenter case–control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users
Authors: Mallah Narmeen , Zapata-Cachafeiro Maruxa , Aguirre Carmelo , Ibarra-García Eguzkiñe , Palacios–Zabalza Itziar , Macías García Fernando , iglesias García Julio , Piñeiro-Lamas María , Ibáñez Luisa , Vidal Xavier , Vendrell Lourdes , Martin-Arias Luis , Gil María Sáinz , Velasco-González Verónica , Salgado-Barreira Ángel , Figueiras Adolfo
Published: October 2021

Bleeding in non-steroidal anti-inflammatory drug (NSAID) users limited their prescription. This first multicenter full case–control study (325 cases and 744 controls), explored the association of e-NOS intron 4 variable number tandem repeat (VNTR) polymorphism with upper gastrointestinal hemorrhage (UGIH) in NSAID exposed and unexposed populations and assessed any interaction between this polymorphism and NSAIDs. NSAID users carrying e-NOS intron 4 wild type genotype or VNTR polymorphism have higher odds of UGIH than those unexposed to NSAIDs [Odds Ratio (OR): 6.62 (95% Confidence Interval (CI): 4.24, 10.36) and OR: 5.41 (95% CI 2.62, 11.51), respectively], with no effect modification from VNTR polymorphism-NSAIDs interaction [Relative Excess Risk due to Interaction (RERI): −1.35 (95% CI −5.73, 3.03); Synergism Index (S): 0.77 (95% CI 0.31, 1.94)]. Similar findings were obtained for aspirin exposure. Non-aspirin NSAID users who carry e-NOS intron 4 VNTR polymorphism have lower odds of UGIH [OR: 4.02 (95% CI 1.85, 8.75) than those users with wild type genotype [OR: 6.52 (95% CI 4.09, 10.38)]; though the interaction estimates are not statistically significant [RERI: −2.68 (95% CI −6.67, 1.31); S: 0.53 (95% CI 0.18, 1.55)]. This exploratory study suggests that the odds of UGIH in NSAID or aspirin users does not modify according to patient´s e-NOS intron 4 genotype.
Scalable, effective, and rapid decontamination of SARS-CoV-2 contaminated N95 respirators using germicidal ultraviolet C (UVC) irradiation device
Authors: Rathnasinghe Raveen , Karlicek Robert F. , Schotsaert Michael , Koffas Mattheos , Arduini Brigitte L. , Jangra Sonia , Wang Bowen , Davis Jason L. , Alnaggar Mohammed , Costa Anthony , Vincent Richard , García-Sastre Adolfo , Vashishth Deepak , Balchandani Priti
Published: October 2021

Particulate respirators such as N95s are an essential component of personal protective equipment (PPE) for front-line workers. This study describes a rapid and effective UVC irradiation system that would facilitate the safe re-use of N95 respirators and provides supporting information for deploying UVC for decontamination of SARS-CoV-2 during the COVID-19 pandemic. To assess the inactivation potential of the proposed UVC germicidal device as a function of time by using 3 M 8211-N95 particulate respirators inoculated with SARS-CoV-2. A germicidal UVC device to deliver tailored UVC dose was developed and test coupons (2.5 cm2) of the 3 M-N95 respirator were inoculated with 106 plaque-forming units (PFU) of SARS-CoV-2 and were UV irradiated. Different exposure times were tested (0–164 s) by fixing the distance between the lamp and the test coupon to 15.2 cm while providing an exposure of at least 5.43 mWcm−2. Primary measure of outcome was titration of infectious virus recovered from virus-inoculated respirator test coupons after UVC exposure. Other measures included the method validation of the irradiation protocol, using lentiviruses (biosafety level-2 agent) and establishment of the germicidal UVC exposure protocol. An average of 4.38 × 103 PFU ml−1 (SD 772.68) was recovered from untreated test coupons while 4.44 × 102 PFU ml−1 (SD 203.67), 4.00 × 102 PFU ml−1 (SD 115.47), 1.56 × 102 PFU ml−1 (SD 76.98) and 4.44 × 101 PFU ml−1 (SD 76.98) was recovered in exposures 2, 6, 18 and 54 s per side respectively. The germicidal device output and positioning was monitored and a minimum output of 5.43 mW cm−2 was maintained. Infectious SARS-CoV-2 was not detected by plaque assays (minimal level of detection is 67 PFU ml−1) on N95 respirator test coupons when irradiated for 120 s per side or longer suggesting 3.5 log reduction in 240 s of irradiation, 1.3 J cm−2. A scalable germicidal UVC device to deliver tailored UVC dose for rapid decontamination of SARS-CoV-2 was developed. UVC germicidal irradiation of N95 test coupons inoculated with SARS-CoV-2 for 120 s per side resulted in 3.5 log reduction of virus. These data support the reuse of N95 particle-filtrate apparatus upon irradiation with UVC and supports use of UVC-based decontamination of SARS-CoV-2 during the COVID-19 pandemic.
sFlt-1 and CA 15.3 are indicators of endothelial damage and pulmonary fibrosis in SARS-CoV-2 infection
Authors: Greco Marilena , Suppressa Salvatore , Lazzari Roberta Assunta , Sicuro Fernando , Catanese Carmelo , Lobreglio Giambattista
Published: October 2021

COVID-19 pandemic led to a worldwide increase of hospitalizations for interstitial pneumonia with thrombosis complications, endothelial injury and multiorgan disease. Common CT findings include lung bilateral infiltrates, bilateral ground-glass opacities and/or consolidation whilst no current laboratory parameter consents rapidly evaluation of COVID-19 risk and disease severity. In the present work we investigated the association of sFLT-1 and CA 15.3 with endothelial damage and pulmonary fibrosis. Serum sFlt-1 has been associated with endothelial injury and sepsis severity, CA 15.3 seems an alternative marker for KL-6 for fibrotic lung diseases and pulmonary interstitial damage. We analysed 262 SARS-CoV-2 patients with differing levels of clinical severity; we found an association of serum sFlt-1 (ROC AUC 0.902, decision threshold > 90.3 pg/mL,p < 0.001 Sens. 83.9% and Spec. 86.7%) with presence, extent and severity of the disease. Moreover, CA 15.3 appeared significantly increased in COVID-19 severe lung fibrosis (ICU vs NON-ICU patients 42.6 ± 3.3 vs 25.7 ± 1.5 U/mL,p < 0.0001) and was associated with lung damage severity grade (ROC AUC 0.958, decision threshold > 24.8 U/mL,p < 0.0001, Sens. 88.4% and Spec. 91.8%). In conclusion, serum levels of sFlt-1 and CA 15.3 appeared useful tools for categorizing COVID-19 clinical stage and may represent a valid aid for clinicians to better personalise treatment.
Size effect on contact behavior in DEM simple shear tests
Authors: Li Yao , Li Jiaping , Zhu Tantan , Han Kuan
Published: October 2021

The 2–2.5 times the simulated sand diameter is widely accepted in giving reasonable DEM simulation results for geotechnical testing. However, it neglects the effect of a specimen height to maximum particle diameter ratio in a specific laboratory test, which may lead to a strong stress concentration and flawed simulations. This study compared laboratory simple shear tests with corresponding DEM simulations with different particle sizes. The DEM model used clump rings to simulate physical rings in the test, and decreased the additional stress applied by the widely used wall-type rings. Results showed that (1) DEM models with tested particle size and twofold sand particle size (1D and 2D tests) can better capture the tested stress–strain behavior, volumetric changes, and noncoaxiality, the 4D model has an asymmetrical distribution of contact force and contact number, indicating the specimen is inhomogeneous and has a strong stress concentration. (2) a specimen height to maximum particle diameter ratio smaller than 10 (it is greater than 10 in the ASTM D6528) could provide reasonable macro-meso mechanical behaviors. Similar studies should be carried out after trial tests on determining a reasonable specimen height to maximum particle diameter ratio under the guidance of ASTM D6528.
Three years pilot of spinal muscular atrophy newborn screening turned into official program in Southern Belgium
Authors: Boemer François , Caberg Jean-Hubert , Beckers Pablo , Dideberg Vinciane , di Fiore Samantha , Bours Vincent , Marie Sandrine , Dewulf Joseph , Marcelis Lionel , Deconinck Nicolas , Daron Aurore , Blasco-Perez Laura , Tizzano Eduardo , Hiligsmann Mickaël , Lombet Jacques , Pereira Tatiana , Lopez-Granados Lucia , Shalchian-Tehran Sarvnaz , van Assche Véronique , Willems Arabelle , Huybrechts Sofie , Mast Bénédicte , van Olden Rudolf , Dangouloff Tamara , Servais Laurent
Published: October 2021

Three new therapies for spinal muscular atrophy (SMA) have been approved by the United States Food and Drug Administration and the European Medicines Agency since 2016. Although these new therapies improve the quality of life of patients who are symptomatic at first treatment, administration before the onset of symptoms is significantly more effective. As a consequence, newborn screening programs have been initiated in several countries. In 2018, we launched a 3-year pilot program to screen newborns for SMA in the Belgian region of Liège. This program was rapidly expanding to all of Southern Belgium, a region of approximately 55,000 births annually. During the pilot program, 136,339 neonates were tested for deletion of exon 7 of SMN1, the most common cause of SMA. Nine SMA cases with homozygous deletion were identified through this screen. Another patient was identified after presenting with symptoms and was shown to be heterozygous for the SMN1 exon 7 deletion and a point mutation on the opposite allele. These ten patients were treated. The pilot program has now successfully transitioned into the official neonatal screening program in Southern Belgium. The lessons learned during implementation of this pilot program are reported.
A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo
Authors: Skuladottir Astros Th. , Bjornsdottir Gyda , Nawaz Muhammad Sulaman , Petersen Hannes , Rognvaldsson Solvi , Moore Kristjan Helgi Swerford , Olafsson Pall I. , Magnusson Sigurður H. , Bjornsdottir Anna , Sveinsson Olafur A. , Sigurdardottir Gudrun R. , Saevarsdottir Saedis , Ivarsdottir Erna V. , Stefansdottir Lilja , Gunnarsson Bjarni , Muhlestein Joseph B. , Knowlton Kirk U. , Jones David A. , Nadauld Lincoln D. , Hartmann Annette M. , Rujescu Dan , Strupp Michael , Walters G. Bragi , Thorgeirsson Thorgeir E. , Jonsdottir Ingileif , Holm Hilma , Thorleifsson Gudmar , Gudbjartsson Daniel F. , Sulem Patrick , Stefansson Hreinn , Stefansson Kari
Published: October 2021

Vertigo is the leading symptom of vestibular disorders and a major risk factor for falls. In a genome-wide association study of vertigo (Ncases = 48,072, Ncontrols = 894,541), we uncovered an association with six common sequence variants in individuals of European ancestry, including missense variants in ZNF91, OTOG, OTOGL, and TECTA, and a cis-eQTL for ARMC9. The association of variants in ZNF91, OTOGL, and OTOP1 was driven by an association with benign paroxysmal positional vertigo. Using previous reports of sequence variants associating with age-related hearing impairment and motion sickness, we found eight additional variants that associate with vertigo. Although disorders of the auditory and the vestibular system may co-occur, none of the six genome-wide significant vertigo variants were associated with hearing loss and only one was associated with age-related hearing impairment. Our results uncovered sequence variants associating with vertigo in a genome-wide association study and implicated genes with known roles in inner ear development, maintenance, and disease.
Offspring production from cryopreserved primordial germ cells in Drosophila
Authors: Asaoka Miho , Sakamaki Yurina , Fukumoto Tatsuya , Nishimura Kaori , Tomaru Masatoshi , Takano-Shimizu Toshiyuki , Tanaka Daisuke , Kobayashi Satoru
Published: October 2021

There is an urgent need to cryopreserve Drosophila stocks that have been maintained as living cultures for a long time. Long-term culture increases the risk of accidental loss and of unwanted genetic alteration. Here, we report that cryopreserved primordial germ cells (PGCs) can produce F1 progeny when transplanted into hosts. The cryopreserved donor PGCs could form germline stem cells in host gonads and contributed to continuous offspring production. Furthermore, the ability to produce offspring did not appear to vary with either differences between donor strains or cryopreservation duration. Therefore, we propose that our cryopreservation method is feasible for long-term storage of various Drosophila strains. These results underscore the potential usefulness of our cryopreservation method for backing up living stocks to avoid either accidental loss or genetic alteration.
Two-photon activated precision molecular photosensitizer targeting mitochondria
Authors: Mariz Inês F. A. , Pinto Sandra N. , Santiago Ana M. , Martinho José M. G. , Recio Javier , Vaquero Juan J. , Cuadro Ana M. , Maçôas Ermelinda
Published: October 2021

Mitochondria metabolism is an emergent target for the development of novel anticancer agents. It is amply recognized that strategies that allow for modulation of mitochondrial function in specific cell populations need to be developed for the therapeutic potential of mitochondria-targeting agents to become a reality in the clinic. In this work, we report dipolar and quadrupolar quinolizinium and benzimidazolium cations that show mitochondria targeting ability and localized light-induced mitochondria damage in live animal cells. Some of the dyes induce a very efficient disruption of mitochondrial potential and subsequent cell death under two-photon excitation in the Near-infrared (NIR) opening up possible applications of azonia/azolium aromatic heterocycles as precision photosensitizers. The dipolar compounds could be excited in the NIR due to a high two-photon brightness while exhibiting emission in the red part of the visible spectra (600–700 nm). Interaction with the mitochondria leads to an unexpected blue-shift of the emission of the far-red emitting compounds, which we assign to emission from the locally excited state. Interaction and possibly aggregation at the mitochondria prevents access to the intramolecular charge transfer state responsible for far-red emission.
Theoretical insights into the possible applications of amidoxime-based adsorbents in neptunium and plutonium separation
Authors: Chen Yan-Mei , Wang Cong-Zhi , Wu Qun-Yan , Lan Jian-Hui , Chai Zhi-Fang , Shi Wei-Qun
Published: October 2021

Quantum chemical calculations demonstrated the potential applications of amidoxime-based adsorbents in neptunium and plutonium separation.
Fabrication and emulsifying properties of non-covalent complexes between soy protein isolate fibrils and soy soluble polysaccharides
Authors: Zhao Hekai , Wang Shengnan , Zhao Guilan , Li Yangyang , Liu Xiulin , Yang Lina , Zhu Lijie , Liu He
Published: October 2021

Soy protein isolate fibrils/soy soluble polysaccharide complexes were fabricated via non-covalent interactions, which could significantly improve emulsion stability with increase in the proportion of polysaccharide.
QM/MM modeling of class A β-lactamases reveals distinct acylation pathways for ampicillin and cefalexin
Authors: Song Zilin , Trozzi Francesco , Palzkill Timothy , Tao Peng
Published: October 2021

QM/MM chain-of-states calculations of CTX-M-44 show distinct acylation profiles for ampicillin and cefalexin, the acylation resistance observed for cefalexin attributes to decreased proton affinity induced by the delocalized π-conjugation.
Monitoring single Au38 nanocluster reactions via electrochemiluminescence
Authors: Hesari Mahdi , Ma Hui , Ding Zhifeng
Published: October 2021

Herein, we report for the first time single Au38 nanocluster reaction events of highly efficient electrochemiluminescence (ECL) with tri-n-propylamine radicals as a reductive co-reactant at the surface of a Pt ultramicroelectrode (UME).
A scaffold membrane of solid polymer electrolytes for realizing high-stability and dendrite-free lithium-metal batteries
Authors: Nguyen Hanh T. T. , Nguyen Dang H. , Zhang Qin-Cheng , Lee Yuh-Lang , Jan Jeng-Shiung , Chiu Chi-Cheng , Teng Hsisheng
Published: October 2021

A PVdF-based scaffold reinforces a solid polymer electrolyte and regulates Li+ transport for uniform Li plating, enabling all-solid-state lithium batteries to exhibit high capacities with stable cycling for 1100 cycles at room temperature.
Synthesis of (MgCoNiCuZn)O entropy-stabilized oxides using solution-based routes: influence of composition on phase stability and functional properties
Authors: Mnasri Walid , Bérardan David , Tusseau-Nenez Sandrine , Gacoin Thierry , Maurin Isabelle , Dragoe Nita
Published: October 2021

The synthesis of all five “4-member” entropy-stabilized oxides derived from the canonical (MgCoNiCuZn)O allows us to evidence the specific roles of each cation in the formation and properties of these materials.
Similarities of magnetoconvection in the umbra and in the penumbra of sunspots
Authors: Löptien B. , Lagg A. , van Noort M. , Solanki S. K.
Published: October 2021

Context. It is unclear why there is a rather sharp boundary in sunspots between the umbra and the penumbra. Both regions exhibit magnetoconvection, which manifests in penumbral filaments in the penumbra and in umbral dots in the umbra.

Aims. Here we compare the physical properties of umbral dots and penumbral filaments. Our goal is to understand how the properties of these convective features change across the boundary between the umbra and the penumbra and how this is related to the rapid increase in brightness at the umbra-penumbra boundary.

Methods. We derived ensemble averages of the physical properties of different types of convective features based on observations of two sunspots with Hinode.

Results. There are strong similarities between the convective features in the outer parts of the umbra and the ones in the penumbra, with most physical parameters being smooth and continuous functions of the length of the features.

Conclusions. Our results indicate that the transition in brightness from the umbra to the penumbra is solely caused by an increased effectiveness of magnetoconvection within individual convective cells. There is no significant difference in the number density of convective elements between the outer umbra and the inner penumbra. Penumbral filaments exhibit a larger area and a higher brightness compared to umbral dots. It is still unclear how exactly the underlying magnetic field causes the increase in the size and brightness of convective features in the penumbra.
Multiple stimuli responsive cyclodextrin based smart materials for drug delivery: a review
Authors: Sandhya Sadanandan , Devika V , Rajeev Niranjana , Sreelekshmi P J , Chandran Amrutha , Goutami G B , Aiswarya Lakshmi S
Published: October 2021

In this review we discuss about the research advances in multiple stimuli responsive cyclodextrin (CD) based smart materials. CD based systems which are responsive to temperature, pH, enzymes, light, redox etc. along with various applications of these systems in the biomedical area are extensively covered. Current challenges and future perspectives of these smart stimuli-responsive drug delivery systems are also discussed.
Natural Disaster Discernment and Vigilance
Authors: Ganapathi Raju N V , Therala Ajay , Yalla Venkat , Ch Rohit Raju , Rajiv K
Published: October 2021

Natural Disasters like cyclones and Earthquakes have a huge impact on the lives of people, results in damage to infrastructure, and lead to injuries and deaths. IoT Based detection systems are utilized for detecting disasters and performing subsequent rescue operations. The challenge with these IoT Based systems is that collecting data from sensors might be failed due to communication breakages or network congestions. To address this issue, this paper has come up with an idea of implementing Disaster Detection using Convolutional Neural Networks and sending SMS to people for making people alert. This paper aims to particularly detect Cyclones and Earthquakes. Data sets were collected from Kaggle. Convolutional Neural Network is a deep learning algorithm that takes an image as input, assigns weights/biases to a variety of aspects in the image for differentiating one from another image. Applications of this work includes disaster preparedness such as forecasts, warnings and predictions, disaster management and disaster relief operations. A comparative study has been performed on CNN and its variants.
Security Framework Connection Assistance for IoT Device Secure Data communication
Authors: Kodati Sarangam , Pradeep Reddy Kumbala , Veerananna Thotakura , Govinda Rao S , Anil Kumar G
Published: October 2021

Today, Internet of Things (IoT) services has been increasing extensively because of their optimum device sizes and their developed network infrastructure that includes devices based on internet embedded with various sensors, actuators, communication, and storage components providing connection and data exchange. Presently number of industries use vast number of IoT devices, there are some challenges like reducing the risks and threats that exposure, accommodating the huge number of IoT devices in network and providing secure vulnerabilities have risen. Supervised learning has recently been gaining popularity to provide device classification. But this supervised learning became unrealistic as producing millions of new IoT devices each year, and insufficient training data. In this paper, security framework connection assistance for IoT device secured data communication is proposed. A multi-level security support architecture which combines clustering technique with deep neural networks for designing the resource oriented IoT devices with high security and these are enabling both the seen and unseen device classification. The datasets dimensions are reduced by considering the technique as auto encoder. Therefore in between accuracy and overhead classification good balancing is established. The comparative results are describes that proposed security system is better than remaining existing systems.
On rheological, mechanical, thermal, wear and morphological properties of melamine formaldehyde reinforced recycled ABS for sustainable manufacturing
Authors: Singh Gulraj , Brar Gurinder Singh , Singh Rupinder
Published: October 2021

This study outline the procedure of filament fabrication for fused deposition modelling (FDM), based upon rheological, mechanical, thermal, wear and morphological characterization as a case study of acrylonitrile butadiene styrene (ABS) - melamine formaldehyde (MF) composite. It has been ascertained that with increase in proportion of MF in ABS, viscosity is improved and melt flow index (MFI) is reduced significantly. As regards to the wear behavior is concerned it has been observed that ABS-MF (12.5 wt.%) composite has shown minimum weight loss and porosity. For the mechanical properties of the composite, experimental results show increased brittleness of the samples with addition of MF reinforcement. The thermal stability analysis was performed using differential scanning calorimetry (DSC) for virgin ABS and samples having 12.5% MF in ABS and results show the increased heat capacity of the material with increase in MF percentage. Further for sustainability analysis (based upon thermal stability), matrix of ABS-MF12.5% was subjected to three repeated thermal (heating-cooling) cycles and it has been ascertained that no significant loss was noticed in heat capacity of recycled composite matrix. The results are also supported by Fourier transform infrared spectroscopy (FTIR) analysis. Overall the results of the rheological, mechanical, wear, morphological and thermal properties suggested that 12.5% proportion of MF can be reinforced into selected grade of ABS thermoplastic for 3D printing as a sustainable solution.
Disruptive Education for Sustainable Development-Cultivating Positive Learning Dispositions
Authors: Rajeswari S. , Khuraijam Gyanabati
Published: October 2021

Education is the process through which sustainable development can be achieved. Learners develop values and skills through proper guidance individually and collectively that enable to improve the quality of life. This paper addresses how teachers need to continually interrogate their practices focusing on improving outcomes of learners. Positive behaviour supports student learning and development in achieving their desired objectives. The methods involve dispositions, the key components for one’s sustainable development. The results suggest that environment with supportive autonomy versus controlling is essential for sustainability. Teachers need to cultivate appropriate positive dispositions in terms of interest, inventiveness and intensiveness. To elevate learning capacity, teachers provide challenging and appealing environments to extend student capabilities thus heightens their efficacy. Rendering the focus on research as eminently topical and pertinent which adds an importance to the existing literature through the direct focus into the classroom space with digital devices where disruption takes place.
Theoretical estimation of efficiency defect in Vapour Compression Refrigeration system using R1234yf, R134a and R1234ze
Authors: Soni Shubham , Mishra Punit , Maheshwari Govind , Verma Devendra S
Published: October 2021

In presented work, researchers have used efficiency defect as a tool for checking the utility of different refrigerants in Vapour compression refrigeration system. A mathematical model of simple Vapour compression refrigeration system is created. Using first law analysis and exergy analysis efficiency defect is calculated for various components of the system individually and whole vapour compression refrigeration system as well. It is found that R1234yf has highest value of efficiency defect for whole system, whereas R134a has least value of efficiency defect for whole system. Variation of efficiency defect of various components with evaporator temperature is also presented as graphs.
Thermodynamic Analysis of Split Air Conditioner Using Energy and Exergy Viewpoint with Low GWP Refrigerants Alternative to R410A
Authors: Mishra Punit , Soni Shubham , Maheshwari Govind
Published: October 2021

In this paper, a comparative thermodynamic analysis on energy and exergy viewpoint is done on different low global warming potential (GWP) refrigerants to find the possible alternative of high GWP refrigerant R410A. R410A is used nowadays in air conditioning systems due to its ozone-friendly characteristic as zero ozone depletion potential (ODP=0) but it has high GWP (GWP=1924) that leads to global warming. Now a day’s global warming is considered to be one of the critical aspects when environmental protection is taken into consideration and researchers from every corner of the globe are working to find refrigerants that not only have zero ODP but it has low GWP too. In this analysis, four prospect refrigerants namely R32, R447A, R447B, and R452B have been studied to find their suitability to replace R410A on different performance criteria as the coefficient of performance (COP), power consumption, exergy efficiency, and exergy destruction. Thermodynamic properties of the studied refrigerants have been taken from the Genetron Properties 1.4 software. The result indicates that all the studied refrigerants have better performance characteristics compared to R410A but R447A has maximum COP and exergy efficiency along with the least total exergy destruction that makes it a possible alternate of R410A.
Base shear variation for irregular G+6, G+9 and G+12 structures in seismic zones IV and V for three soil types
Authors: Cotipalli Vanadeep
Published: October 2021

It is attempted to expand upon the understanding on the structure’s behaviour when the seismic force, which is one of the predominant lateral forces, is applied on the structure. The base shear is calculated and compared for various variable parameters. For the three soil types the base shear is contrasted while varying the building heights of an irregularly planned structure in the seismic zones: IV and V. The structures’ heights are taken as follows: G+6, G+9, G+12 and storey height as 3m. Concluded observations talks about the amount of the variation in the base shear when the structure height and soil types are altered. While the G+9 and G+12 structures behaved identically, the G+6 structures in the medium and the soft soils fetched same results.
Performance evolution of aerated concrete varying with percentage aluminium content
Authors: Satyanarayana G.V.V. , Deepak Reddy S.
Published: October 2021

Aerated Concrete (AC) is flexible light weight cement and they are commonly utilized as squares. The investigation of AAC supplanting regular sand by fly debris is examined. Structure AC blend having blend extent 1:3 with water concrete proportion of 0.6 in these examples utilizing with lime, the sand is continually utilized in the examples. The aluminum powder is utilized at the range of 0.25, 0.5, 0.75, and 1gms of absolute load of cement. The properties of the mortar, like thickness, water assimilation and pressure quality for 24 hours stream restoring were resolved. The development material AC contains 60% to 85% air by volume.
Study on aerated concrete using steam curing test method
Authors: Naidu T Y Rohith , Satyanarayana G.V.V
Published: October 2021

The Accumulation of warm and moisture in building walls plays an vital role in its upkeep and power conservation. Aerated Concrete block, an environmental material gives an anticipated result to building construction. Aerated Concrete can build light weight, eco-friendly, non-structural wall, reduced dead weight concrete blocks. Aerated Concrete is developed introducing aluminium powder which reacts with the calcium hydroxide on hydration of cement. Several curing test methods are done to find out the optimum dosage of aluminium content. The Aerated concrete blocks are pre-casted by mixing Portland cement, fly ash, GGBS, quarry dust, lime stone powder, water and aluminium powder.
Decision support water management a case study
Authors: VenkatCharyulu S. , Viswanadh G.K.
Published: October 2021

Decision support water. Management (DSWM) is an approach to water development and water management, for the best water management framework. In the field of water management for watter storage, and preservation of land is very important criteria which is linked with various communities involvement, economical issues and environmental issues. DSWM. water resources needed extensive advance technology with reliable activity. For this purpose in this paper it need to analyse the various volume, quality and quantity parameters and other enhance model usage are adopted to maintain the effective water resource management.. Parameters collect the management tools for efficient management of water resources under varied local situations. In This paper discussed some of the analytical management techniques and development decision support water management system as a framework for decision makers to have reliable decisions for water management practises. This paper includes overall DSWM functions and their highlights to achieve the effective water management.
Combining Taguchi method and DEAR method for multi-objective optimization of grinding process
Authors: Trung Do Duc , Quang Nguyen Huu , Cuong Dang Quoc , Linh Nguyen Hong , Tuan Nguyen Van. , Hung Le Xuan , Tuan Nguyen Anh
Published: October 2021

In this paper, a study on multi-objective optimization of the cylindrical grinding process is presented. The experimental material used in this study is X12M steel. The two output parameters of the grinding process considered in this study are surface roughness and material removal rate (MRR). The cutting mode parameters including cutting speed, feed rate, and cutting depth have been selected as input parameters of the experimental process. Experimental matrix by Taguchi method has been used to design a matrix with 27 experiments. Analysis of experimental results by Pareto chart has determined the effect of input parameters on output parameters. The Data Envelopment Analysis-based Ranking (DEAR) method has been applied to determine the values of input parameters to simultaneously ensure the two criteria of minimum surface roughness and maximum MRR. Finally, the development direction for further studies has also been recommended in this study.
Advances in chemistry of carbon nanotubes and their composites (nanomaterial): A Review
Authors: Gagandeep  , Pathania Anuradha
Published: October 2021

This review is about the commercial as well as some other applications of carbon nano materials as in recent past years their various beneficial properties (physical & chemical) have revealed. Carbon nanotubes are cylindrical bodies that are made by rolling single-layered carbons means graphene. They can be of one wall i.e., single walled (SWCNT) having diameter less than 1nm and also can be multilayered or multi walled (MWCNT). More & more nanotubes join concentrically to make themselves multilayered (diameter – more than 100nm). Previous strives on these nanotubes has revealed their various properties like high thermal conductivity, outstanding field emission properties & controlled electronic properties etc. It has been proven that carbon nanotubes are ideal model system for studying physics in one dimensional solid. Other aspects related to nanomaterials and its various derivatives can be better understood by glancing below.
Detecting anomalous road traffic conditions using VGG19 CNN Model
Authors: Rajeshwari M. , MallikarjunaRao CH.
Published: October 2021

Detection on the real time road traffic has tremendous application possibilities in metropolitan road safety and traffic management. Due to the effect of numerous factors, for example: climate, viewpoints and road conditions in real-time traffic scene, Anomaly detection actually faces many difficulties. There are many reasons for vehicle accidents, for example: crashes, vehicle on flames and vehicle breakdowns, which exhibits distinctive and obscure behaviours. In this paper, we approached with a model to identify oddity in street traffic by monitoring the vehicle movement designs in two unmistakable yet associated modes which is 1. The vehicle’s dynamic mode and 2. The vehicle’s Static mode. The vehicle’s static mode investigation is gained using the background modelling after the detection of a vehicle, this strategy is useful to locate the unusual vehicle movement which keep still out and about. The dynamic mode vehicle examination is gained from identified and followed vehicle directions to locate the strange direction which is distorted from the predominant movement designs. The outcomes from the double mode investigations are at long last fused together by driven a distinguishing proof model to get the last peculiarity. For this research we are using traffic-net Dataset, VGG19 CNN model along with ImageNet weights and OpenCV.
Mathematical analysis of an age structured epidemic model with a quarantine class
Authors: Sari Zakya , Touaoula Tarik Mohammed , Ainseba Bedreddine
Published: October 2021

In this paper, an age structured epidemic Susceptible-Infected-Quarantined-Recovered-Infected (SIQRI) model is proposed, where we will focus on the role of individuals that leave the R-class before being completely recovered and thus will participate again to the disease transmission. We investigate the asymptotic behavior of solutions by studying the stability of both trivial and positive equilibria. In order to see the impact of the different model parameters like the relapse rate on the qualitative behavior of our system, we firstly, give an explicit expression of the basic reproduction number R0, which is a combination of the classical basic reproduction number for the SIQR model and some other model parameters, corresponding to the individuals infected by the relapsed ones. It will be shown that, if R0 ≤ 1, the disease free equilibrium is globally asymptotically stable and becomes unstable for R0 > 1. Secondly, while R0 > 1, a suitable Lyapunov functional is constructed to prove that the unique endemic equilibrium is globally asymptotically stable on some subset Ω0.
Tentatives de réparation narcissique suite à la perte d’un parent à l’adolescence
Authors: Bernard Alix
Published: October 2021

À partir de l’œuvre de l’écrivain, William Styron, nous évoquons le traumatisme représenté par la perte d’un parent à l’adolescence et les différentes stratégies adoptées pour y faire face. Dans le récit autobiographique « Face aux ténèbres. Chronique d’une folie », écrit à l’âge de 65 ans, Styron rend compte de la dépression mélancolique qu’il vient de traverser. Cette chronique se termine par l’évocation de la mort de sa mère quand il avait treize ans, souvenir soudainement retrouvé après avoir écouté une mélodie de Brahms, qu’elle avait autrefois chanté. Styron introduit alors l’hypothèse d’un deuil gelé à la suite de cette perte, puis il évoque le désir de guérir qui accompagne cette reviviscence. Dans trois nouvelles publiées par la suite, « Un matin de Virginie – Trois histoires de jeunesse », Styron poursuit ce travail de mémoire et suit le fil associatif de ses souvenirs, reflétant ses expériences à l’âge de vingt, dix et treize ans. L’auteur donne des clés pour comprendre ce qui avait pu être source de souffrance, les défenses pour y échapper, les solutions successivement trouvées pour affronter – ou non – ce traumatisme : l’engagement dans l’armée, l’écriture, le recours à l’alcool. Ces nouvelles témoignent de la reprise tardive du travail de deuil suspendu à l’adolescence.
Ces douleurs qui insistent à l’adolescence : l’hospitalisation en Soins/Études peut-elle être une réponse ?
Authors: Tonelli Anne
Published: October 2021

Le service de médecine interne pour adolescents accueille en hospitalisation des adolescents douloureux chroniques déscolarisés, en échec de suivi ambulatoire de Structure Douleur, dans un projet Soins/Études axé sur l’évaluation et le traitement de leur douleur et la reprise de leur scolarité. La remise en mouvement du corps douloureux, l’adaptation des traitements médicamenteux et la gestion des crises douloureuses, les entretiens psychologiques, la scolarité bienveillante sans pression, la mise à distance de la famille assortie du travail avec celle-ci permettent à l’adolescent de faire un pas de côté et de se décentrer de sa douleur. En partant de l’expérience de 237 hospitalisations et à travers une vignette clinique, les auteurs décrivent le profil des adolescents hospitalisés, le dispositif mis en place et son fonctionnement.
Barrieren und Förderfaktoren in der evidenzbasierten Praxis (EBP) der Physiotherapie – Eine Bestandsaufnahme und Eruierung von Barrieren und Förderfaktoren zur Anwendung von EBP mit Physiotherapeut*innen der deutschsprachigen Schweiz
Authors: Freitag Livia , Hohenauer Erich , Deflorin Carlina , Böni André Christoph , Clijsen Ron
Published: October 2021

Hintergrund Die Akademisierung der Gesundheitsberufe führte in der Physiotherapie zu einem Wechsel von primär erfahrungsbasiertem zu evidenzbasiertem Arbeiten. Obwohl das Konzept der evidenzbasierten Praxis (EBP) in der Physiotherapie weitgehend akzeptiert ist, zeigen sich Probleme bei der Umsetzung in die Praxis.

Ziel Identifikation potentieller Barrieren und unterstützender Faktoren für die Umsetzung der evidenzbasierten Praxis in der Physiotherapie.

Methode Anhand eines Onlinefragebogens mit 49 Fragen wurden Physiotherapeut*innen (n = 138) zur evidenzbasierten Praxis befragt. Die Resultate des Fragebogens wurden deskriptiv wiedergegeben.

Ergebnisse Physiotherapeut*innen mit Masterabschluss arbeiten im Arbeitsalltag evidenzbasierter als Physiotherapeut*innen mit anderen Abschlüssen und zeigen eine höhere Bereitschaft, evidenzbasierte Praxis anwenden zu wollen. Unsicherheiten wurden vorwiegend beim Formulieren von Fragestellungen sowie bei der Suche und kritischen Bewertung von wissenschaftlichen Artikeln festgestellt. Eine Aus- oder Weiterbildung zur evidenzbasierten Praxis führt zu mehr Sicherheit bei deren Anwendung. Klinische Entscheidungswege basieren vorwiegend auf der eigenen Praxiserfahrung, dem Befinden von Patient*innen und auf Informationen aus Fachzeitschriften. Zeitmangel, sich während der Arbeit weiterzubilden, stellt die Hauptbarriere dar. Zusammengefasste Forschungsergebnisse publiziert auf einem evidenzbasierten Internetportal, per E-Mail-Versand oder in einer Fachzeitschrift sind die meistgenannten Förderfaktoren für die Anwendung evidenzbasierter Praxis.

Schlussfolgerung Fach- und Hochschulen sowie Arbeitgeber*innen spielen eine wichtige Rolle bei der Vermittlung von Kenntnissen und der Umsetzung von evidenzbasierter Praxis in der Physiotherapie.
COVID-19: Das Endspiel
Authors: Wildner Manfred
Published: October 2021

Nachdem die Fußball-Europameisterschaft im ersten Pandemie-Jahr 2020 abgesagt worden war, fand sie ein Jahr später, in den Sommermonaten des Jahres 2021 an elf Spielorten in Europa statt. Die Spiele in Städten, welche einen Einlass von Zuschauern in die dortigen Stadien nicht zusagen wollten, wurde an andere Orte vergeben. Die (Halb-)Finalspiele wurden alle im traditionsreichen Wembley-Stadion in London ausgetragen, einer Arena mit 65 000 genutzten Plätzen. Das Endspiel war dramatisch, letztlich unterlag die englische Mannschaft nach der Verlängerung gegen Italien im Elfmeterschießen.
Intramolecular Oxidative Diaryl Coupling of Tetrasubstituted Diphenylamines for the Preparation of Bis(trifluoromethyl) Dimethyl Carbazoles
Authors: Duda Addison M. , Guarr Thomas F. , Giurini Michael T. , Gillmore Jason G.
Published: October 2021

Synthetic preparation of carbazoles can be challenging, requiring ring-building strategies and/or precious metal catalysts. Presented herein is a method for the preparation of carbazoles with the use of inexpensive and reliable hypervalent iodine chemistry. An oxidative single-electron-transfer (SET) event initiates cyclization for the preparation of our trifluoromethyl carbazoles. This method has been shown to be useful for a variety of bis(trifluoromethyl)carbazole isomers that are of primary interest for use as battery materials.
Prevalence of Enchondromas of the Proximal Femur in Adults as an Incidental Finding on MRI of the Pelvis
Authors: Davies A. M. , Patel A. , Azzopardi C. , James S. L. , Botchu R.
Published: October 2021

Objective To determine the prevalence of enchondroma in adults as an incidental finding in the proximal femur on magnetic resonance imaging (MRI).

Materials and Methods A retrospective review of the MRI scans of the pelvis in a series of adult patients was conducted. All presented with nononcological musculoskeletal complaints. The site, size, and appearances of the enchondromas were identified according to criteria from previous studies.

Results A total of 1,209 proximal femora in 610 patients were reviewed and a total of 9 enchondromas were identified. These ranged from 0.6 to 2.5 cm in length (mean 1.3 cm). None showed aggressive features suggestive of malignancy. Three cases (33%) underwent follow-up MRI scans which showed no change in size or morphology.

Conclusion The prevalence on MRI of incidental enchondromas arising in the proximal femur is 0.7%. This is three to four times less common than seen in the proximal humerus and around the knee.
Role of SCO-792, A Novel Enteropeptidase Inhibitor, In the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Authors: Rashid Mohammed Yousif , Gnawali Anupa
Published: October 2021

Acute pancreatitis is the most common iatrogenic dilemma of endoscopic retrograde cholangiopancreatography, and it is associated with significant morbidity and mortality. Several factors have been implicated in the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis, and preventive measures were practiced accordingly. This study aims to refine the potential mechanisms that trigger post-endoscopic retrograde cholangiopancreatography pancreatitis and define the role of enteropeptidase in the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis. Furthermore, address the role of a new novel medication known as SCO-792, a potent enteropeptidase inhibitor, in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis.

Post-endoscopic retrograde cholangiopancreatography pancreatitis is caused by premature activation of the pancreatic enzymes within the pancreatic parenchyma. This activation is either an autoactivation due to direct provocation of intra-acinar enzymes as a result of the procedure or due to activation by enterpeptidase, a rate-limiting enzyme. Endoscopic retrograde cholangiopancreatography interjects duodenal juice that is rich in enterokinase into the pancreatic-biliary tract, which in turn leads to intra-ductal activation of trypsinogen and subsequent enzymes. Given the vital role of enterokinase in initiating the pathogenesis of pancreatitis, enteropeptidase inhibition may prevent and reduce the severity of post-endoscopic retrograde cholangiopancreatography pancreatitis.

SCO-792, a novel enteropeptidase inhibitor, is developed by SCOHIA Pharma, and pre-clinical trials confirmed its efficacy in inhibiting enteropeptidase. Studies are needed to confirm the efficacy of enteropeptidase inhibitors in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis.
Windsurfing analysis breaks down propulsion mechanics of sailboards
Authors: Rodriguez Jaimee-Ian
Published: October 2021

Sail pumping characterization leads to insights on propulsive power.