bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrocardiographic modifications and cardiac involvement in COVID-19 patients: results from an Italian cohort
Authors: Matteucci Andrea , Massaro Gianluca , Sergi Domenico , Bonanni Michela , Stifano Giuseppe , Matino Matteo , Zerillo Bartolomeo , Rogliani Paola , Romeo Francesco
Published: January 2021

Aim

The aim of this study was to detect predisposing CV risks factors and ECGs changes in COVID-19 patients.

Methods

The study population included 60 noncritically ill patients with COVID-19 pneumonia admitted to our hospital between 16 March and 11 May 2020. Electrographic changes, evaluated from ECGs acquired at admission and at 7 days after starting COVID-19 therapy, were analysed. We also compared 45 patients without CV involvement with 15 patients with new onset of cardiac adverse events during hospitalization.

Results

ECGs under treatment showed a lower heart rate (HR) (69.45 ± 8.06 vs 80.1 ± 25.1 beats/min, P = 0,001) and a longer QRS (102.46 ± 15.08 vs 96.75 ± 17.14, P = 0.000) and QT corrected (QTc) interval (452.15 ± 37.55 vs 419.9 ± 33.41, P = 0,000) duration than ECGs before therapy. Fifteen patients (25%) showed clinical CV involvement. Within this group, female sex, lower ejection fraction (EF), low serum haemoglobin, high Troponin I levels (TnI), low lymphocytes count, high serum IL-6 levels, or use of Tocilizumab (TCZ) were more represented.

Conclusions

Patients admitted for SARS-CoV2 infection and treated with anti-COVID-19 drug therapy develop ECG changes such as reduction in HR and increase in QRS duration and QTc interval. One in four patients developed CV events. Gender, EF, heamoglobin values, TnI, lymphocytes count, IL-6 and use of TCZ can be considered as predisposing factors for CV involvement.
Clinical predictors and prognostic role of high Killip class in patients with a first episode of anterior ST-segment elevation acute myocardial infarction
Authors: Del Buono Marco Giuseppe , Montone Rocco A. , Rinaldi Riccardo , Gurgoglione Filippo Luca , Meucci Maria Chiara , Camilli Massimiliano , Iannaccone Giulia , Sanna Tommaso , Pedicino Daniela , Trani Carlo , Niccoli Giampaolo , Crea Filippo
Published: January 2021

Aims

Killip classification is a simple and fast clinical tool for risk stratification of patients presenting with acute coronary syndrome (ACS). However, the clinical features and predictors of high Killip class at admission, and its prognostic impact in patients presenting with anterior ST elevation MI (STEMI) as first clinical cardiovascular event are still poorly known. The aim of this study was to identify the predictors of high Killip class and its impact on in-hospital and follow-up outcomes.

Methods

We prospectively enrolled patients with unheralded anterior STEMI because of proximal or mid left anterior descending (LAD) artery categorized according to Killip classification. Patients’ characteristics, in-hospital complications and major adverse cardiovascular events (MACEs; composite of all-cause death, heart failure hospitalization and new-onset ACS) at follow-up were collected.

Results

We enrolled 147 patients [age 66.16±13.33, 113 male patients (76.9%)]. Killip class III--IV occurred in 22 (15%) patients. The median duration of follow-up was 12 [6--15.1] months. At multivariate analysis age [hazard ratio 1.137, 95% CI (1.068--1.209), P < 0.001], prehospital cardiac arrest [hazard ratio 12.145, 95% CI (1.710--86.254), P = 0.013] and proximal LAD lesion [hazard ratio 5.066, 95% CI (1.400--18.334), P = 0.013] were predictive of Killip class III--IV at admission. At multivariate analysis, Killip class III--IV was an independent predictor of in-hospital mortality [hazard ratio 7.790, 95% CI (1.024--59.276], P = 0.047 and of MACEs [hazard ratio 4.155 (1.558--11.082), P = 0.004) at follow-up.

Conclusion

Killip classification performed at the time of admission is a simple and useful clinical marker of a high risk of early and late adverse cardiovascular events.
A Saudi child with Sphingosine Phosphate Lyase insufficiency syndrome
Authors: Alrayes Lamya , Alotaibi Mohammed , Alsagheir Afaf
Published: January 2021

Background: Sphingosine Phosphate Lyase Insufficiency Syndrome SPLIS is a recently described condition, which is associated with loss of function mutations in SGPL1, encoding sphingosine-1-phosphate lyase. In 2017, several groups reported this novel childhood syndrome that featured a wide range of presentations including fetal hydrops, steroid-resistant nephrotic syndrome (SRNS), primary adrenal insufficiency (PAI), rapid or insidious neurological deterioration, immunodeficiency, acanthosis and endocrine abnormalities.
Case Presentation: A 7-year-old boy was presented to us with primary adrenal insufficiency on hydrocortisone following pediatrics endocrinology at our hospital. Genetic testing identified a homozygous variant of sphingosine-1-phosphate lyase 1 (NM 003901: exon8: c.665G>A: p.R222Q). At the same time, he was found to have nephrotic syndrome, and renal function rapidly deteriorated. Biopsy of the right kidney showed focal segmental glomerulosclerosis with collapsing features and acute interstitial nephritis. Later, he received a living- related renal transplant. He is doing well after the transplant.
Conclusion: Patients with primary adrenal insufficiency should be carefully followed to develop nephrotic syndrome features, and molecular testing is the key to the diagnosis of the underlying etiology. This is the first reported case with sphingosine-1-phosphate lyase 1 that underwent renal transplantation in our region.
TATA KELOLA DAN ADMINISTRASI BUMDES
Authors: Ayu Maristiana , Azriya Niar , Windari Komang Tri
Published: January 2021

BUMDes dibentuk dengan tujuan untuk meningkatkan kesejahteraan masyarakat lokal desa, meningkatkan kondisi perekonomian dan Pendapatan Asli Desa (PAD), meningkatkan upaya pengolahan potensi desa (sumber daya manusia dan sumber daya alam) sesuai dengan kebutuhan masyarakat desa serta difungsikan untuk menjadi tulang punggung pemerataan dan pertumbuhan ekonomi desa. Masyarakat di Pekon Wates Timur telah memiliki BUMDes dengan kegiatan usaha desa adalah ternak kambing  dan bentuk usaha simpan pinjam, dalam kegiatannya masih ada terkendala dalam pengelolaan administrasi keuangannya dalam hal ini pengelolaan usaha simpan pinjam yang belum terkoordinir dengan baik. Informasi Penentuan sisa nilai piutang dari kegiatan simpan pinjam ini masih kurang transparansi sehingga perlu adanya pengelola keuangan yang lebih efektif dan efisien dalam pengelolaan adminstrasi keuangan tersebut. Pengetahuan tentang pengelolaan administrasi keuangan BumDes perlu ditingkatkan, mengingat SDM yang belum memahami bagaimana pembukuan dengan benar sehingga gambaran transparansi dalam pelaporan belum tergambar dengan jelas. Sumber Daya Manusia yang digunakan hendaknya ditempatkan tenaga yang lebih focus dan memahami technologi  dalam membuat laporan keuangan BUMDes.
PENGARUH SUPERVISI AKADEMIK KEPALA SEKOLAH DAN BUDAYA KERJA TERHADAP KINERJA GURU DI SD AL-AZHAR 2 KOTA BANDAR LAMPUNG
Authors: . Aprianis
Published: January 2021

bstrak. Tujuan penelitian ini adalah untuk mengetahui pengaruh supervisi akademik kepala sekolah dan budaya kerja terhadap kinerja guru di SD Al-Azhar 2 Kota Bandar Lampung. Penelitian yang dilaksanakan adalah jenis Penelitian Deskriptif kuantitatif dengan metode analisis menggunakan regresi linear. Metode pengumpulan data menggunakan data skunder dan data primer. Teknik pengumpulan data menggunakan observasi dan kuesioner Berdasarkan penelitian dapat disimpulkan bahwa Terdapat pengaruh supervisi akademik kepala sekolah terhadap kinerja guru SD Al-Azhar 2 Kota Bandar Lampung, Terdapat pengaruh budaya kerja terhadap kinerja guru SD Al-Azhar 2 Kota Bandar Lampung, besarnya pengaruh supervisi akademik kepala sekolah dan budaya terhadap kinerja guru sebesar 35,1%, dan sisanya sebesar 64,9% akibat penyesuaian faktor lain. Kata Kunci: Supervisi, Budaya Kerja, Kinerja Guru PENDAHULUAN
El carácter de la filosofía rosminiana
Authors: Buganza Jacob
Published: January 2021

Este libro constituye una suerte de introducción a algunas partes del pensamiento de Antonio Rosmini. Aun sin ser un libro orgánico, esto es, una invitación sistemática a su pensamiento, sí que puede ser considerado una puerta de entrada a su filosofía, ya que de inicio se expone el sistema grosso modo, y luego se exploran las partes fundamentales de su ontología, antropología, ética y filosofía del derecho. El pensamiento del filósofo roveretano puede ser tildado de un filosofar riguroso y claro, pues busca la manera en que los principios se enarbolan y examina las deducciones que se siguen de ellos con el fin de explicar la realidad en su totalidad. Tal vez lo que anima la filosofía de Rosmini es lo que él mismo escribe en la Historia comparativa y crítica en torno al principio de la moral: “El deber propio de la filosofía está, como he dicho, en expresar en palabras todos los conceptos plenamente, sin obviar alguna cosa”. Este trabajo se une a otros más sistemáticos del autor, entre los que se recuerdan El ser y el bien (Stresa, 2010), Nomología y eudemonología (Stresa, 2013), Rosmini y la ética fenomenológica (Xalapa, 2016) y El dinamismo del ser trinitario (Barcelona, 2017).
Farmakoterapia skóry. Cz. 1. Budowa i fizjologia skóry
Authors: Wolski Tadeusz , Kędzia Bogdan
Published: January 2021

The study presents the structure and physiology of the skin in terms of transport and ways of permeation of medicinal and cosmetic substances of plant origin through the skin. Human skin structure is composed of three layers: the epidermis, true skin and subcutaneous tissue. The skin is composed also of appendages: sudoriferous and sebaceous glands, hair and nails. In addition, we distinguish blood and lymphatic vessels as well as sensory nerves. The paper also discusses the role of the horny barrier, the reaction and water-lipid layer of the skin and its microflora. The most important functions of the skin are: protective role in relation to mechanical, physical, chemical and microbiological factors, thermoregulation of the body, the role in the secretory and water management, participation in the synthesis of some compounds (e.g. vitamin D) and protein, lipid and carbohydrate metabolism, complicity in the body’s immune response and in the conductivity of sensory impulses.
Photocatalyst-Independent Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides: Stereocontrol and Mechanism
Authors: Zhong Yongliang , feng quanyou , wang xiaoqian , Yang Lei , Tong Rong
Published: January 2021

Photoredox ring-opening polymerization of O-carboxyanhydrides allows for the synthesis of polyesters with precisely controlled molecular weights, molecular weight distributions, and tacticities. While powerful, obviating the use of precious metal-based photocatalysts would be attractive from the perspective of simplifying the protocol and enabling unexpected reactivity. Herein, we report the Co and Zn catalysts that are activated by external light to mediate efficient ring-opening polymerization of O-carboxyanhydrides, without the use of exogenous precious metal-based photocatalysts. Our methods allow for the synthesis of isotactic polyesters with high molecular weights (>200 kDa) and narrow molecular weight distributions (Mw/Mn < 1.1). Mechanistic studies indicate that light activates the oxidative status of CoIII intermediate that is generated from the regioselective ring-opening of the O-carboxyanhydride. We also demonstrate that the use of Zn or Hf complexes together with Co can allow for stereoselective photoredox ring-opening polymerizations of multiple racemic O-carboxyanhydrides to synthesize syndiotactic and stereoblock copolymers, which vary widely in their glass transition temperatures.
Mixed Metal-Antimony Oxide Nanocomposites: Low pH Water Oxidation Electrocatalysts with Outstanding Durability at Ambient and Elevated Temperatures
Authors: Sibimol Luke , Chatti Manjunath , Yadav Asha , Kerr Brittany , Kangsabanik Jiban , Williams Tim , Cherepanov Pavel V. , Tanksale Akshat , Johannessen Bernt , Macfarlane Douglas , Hocking Rosalie K. , Alam Aftab , Yella Aswani , Simonov Alexandr
Published: January 2021

Electrochemical water splitting with a proton-exchange membrane electrolyte provides many advantages for the energy-efficient production of high-purity H2 in a sustainable manner, but the current technology relies on high loadings of expensive and scarce iridium at the anodes, which are also often unstable in operation. To address this, the present work scrutinises the electrocatalytic properties of a range of mixed antimony-metal (Co, Mn, Ni, Fe, Ru) oxides synthesised as thin films by a simple solution-based method for the oxygen evolution reaction in aqueous 0.5 M H2SO4. Among the noble-metal free catalysts, cobalt-antimony and manganese-antimony oxides demonstrate good stability over 24 h and reasonable activity at 24 ± 2 °C, but slowly lose their initial activity at elevated temperatures. The ruthenium-antimony system is highly active, requiring an overpotential of only 0.39 ± 0.03 and 0.34 ± 0.01 V to achieve 10 mA cm-2 at 24 ± 2 and 80 °C, respectively, and most importantly, remaining remarkably stable during one-week tests at 80 °C. Detailed characterisation reveals that the enhanced stability of metal-antimony oxides water oxidation catalysts can arise from two distinct structural scenarios: either formation of a new antimonate phase, or nanoscale intermixing of metal and antimony oxide crystallites. Density functional theory analysis further indicates that the stability in operation is supported by the enhanced hybridisation of the oxygen p- and metal d-orbitals induced by the presence of Sb.
Catalyst Design in C–H Activation: A Case Study in the Use of Binding Free Energies to Rationalise Intramolecular Directing Group Selectivity in Iridium Catalysis
Authors: Kerr William , Knox Gary J. , Reid Marc , Tuttle Tell
Published: January 2021

Remote directing groups in a bifunctional molecule do not always behave independently of one another in C–H activation chemistries. A combined DFT and experimental mechanistic study to provide enhanced Ir catalysts for chemoselective C–H deuteration of bifunctional aryl primary sulfonamides is described. This provides a pharmaceutically relevant and limiting case study in using binding energies to predict intramolecular directing group chemoselectivity. Rational catalyst design, guided solely by qualitative substrate-catalyst binding free energy predictions, enabled intramolecular discrimination between competing ortho directing groups in C–H activation and delivered improved catalysts for sulfonamide-selective C–H deuteration. As a result, chemoselective binding of the primary sulfonamide moiety was achieved in the face of an intrinsically more powerful pyrazole directing group present in the same molecule. Detailed DFT calcualtions and mechanistic experiments revealed a breakdown in the applied binding free energy model, illustrating the important interconnectivity of ligand design, substrate geometry, directing group cooperativity, and solvation in supporting DFT calculations. This work has important implications around attempts to predict intramolecular C–H activation directing group chemoselectivity using simplified monofunctional fragment molecules. More generally, these studies provide insights for catalyst design methods for late-stage C–H functionalisation.
Aerobically Stable and Substitutionally Labile α-Diimine Rhenium Dicarbonyl Complexes
Authors: Schindler Kevin , Crochet Aurélien , Zobi Fabio
Published: January 2021

New synthetic routes to aerobically stable and substitutionally labile a-diimine rhenium(I) dicarbonyl complexes are described. The molecules are prepared in high yield from the cis-cis-trans-[Re(CO)2(tBu2bpy)Br2]- anion (2, where tBu2bpy is 4,4'-di-tert-butyl-2,2'-bipyridine), which can be isolated from the one electron reduction of the corresponding 17-electron complex (1). Compound 2 is stable in the solid state, but in solution it is oxidized by molecular oxygen back to 1. Replacement of a single bromide of 2 by s-donor monodentate ligands (Ls) yields stable neutral 18-electron cis-cis-trans-[Re(CO)2(tBu2bpy)Br(L)] species. In coordinating solvents like methanol the halide is replaced giving the corresponding solvated cations. [Re(CO)2(tBu2bpy)Br(L)] species can be further reacted with Ls to prepare stable cis-cis-trans-[Re(CO)2(tBu2bpy)(L)2]+ complexes in good yield. Ligand substitution of Re(I) complexes proceeds via pentacoordinate intermediates capable of Berry pseudorotation. In addition to the cis-cis-trans-complexes, cis-cis-cis- (all cis) enantiomers are also formed. In particular, cis-cis-trans-[Re(CO)2(tBu2bpy)(L)2]+ complexes establish an equilibrium with all cis enantiomers in solution. The solid state crystal structure of nearly all molecules presented could be elucidated. The molecules adopt a slightly distorted octahedral geometry. In comparison to similar fac-[Re(CO)3]+complexes, Re(I) diacarbonyl species are characterized by a bend (ca. 7°) of the axial ligands towards the a-diimine unit. [Re(CO)2(tBu2bpy)Br2]- and [Re(CO)2(tBu2bpy)Br(L)] complexes may be considered as synthons for the preparation of a variety of new stable diamagnetic dicarbonyl rhenium cis-[Re(CO)2]+ complexes, offering a convenient entry in the chemistry of the core.
Recent Analysis on new Nanoemulgel Transdermal Drug Delivery System use for Skin Disease Treatment
Authors: Ramesh K  , Venkateswara Rao J  , Srinivasan M.K.  , Sravanathi P
Published: January 2021

Nanoemulsions have the potential in medical industries due to transparency at high droplet volume division, higher bio availability rate and expanded shelf life of drugs. The “Nano emulsion-based gel" is a very interesting transdermal delivery framework as it has double delivery control framework, i.e., nano emulsion & hydrogel. The Nano emulgel having nanosized emulsion goes from 10-100μm may quickly enter and convey dynamic substance more profound and faster. The gelling limit of this compound permits the definition of stable emulsion and creams by diminishing surface and interfacial pressure simultaneously expanding the consistency of watery stage. Regardless of the many preferred position of gels, a significant restriction is in delivery of hydrophobic medication. So to defeat this constraint, an emulsion-based methodology is being utilized to that even a hydrophobic moiety might appreciate exceptional property of gel. They have clingy causing distress, less spreading coefficient, scouring is a requirement for application to the skin, and they show the issue of solidness for detailing. Due to all these disadvantages, gels are selected for both cosmetic as well as a pharmaceutical formulation. Despite several benefits of gels, the main drawback is with the delivery of hydrophobic therapeutic moiety. So, emulgel based approach is used to overcome this drawback; by this, even a hydrophobic drug might be included and delivered successfully. When emulsions and gels are mixed than that dosage form is mentioned as emulgel. In fact, the existence of a gelling agent changes conventional emulsion into an emulgel in the water phase.
UROLITÍASE EM CAVIA PORCELLUS SUBMETIDA À CISTOTOMIA: RELATO DE CASO/ Urolithiasis in Cavia porcellus submitted to cystotomy: case report
Authors: Hammarstrom Dobler Guilherme , Mori Viero Luciana , Lukarsewski Rafael , Beck Cristiane
Published: January 2021

Urolitíase é uma doença multifatorial e possui uma casuística elevada em Cavia porcellus. Os urólitos podem ser encontrados em múltiplas regiões do trato urinário desses animais. Dentre machos e fêmeas, as fêmeas apresentam maior incidência sendo a patofisiologia pouco compreendida. Sinais clínicos são importantes para o correto diagnóstico, no entanto, exames de imagem são mecanismos cruciais para a determinação de urólitos ao longo do sistema urinário. Dentre as opções para o tratamento, os procedimentos cirúrgicos são os mais utilizados. Diante disso, o presente relato discute o percurso clínico-cirúrgico de C. porcellus, fêmea, destacando o procedimento anestésico adotado durante cistotomia.
ESTUDO ANATOMOPATOLÓGICO DOS CASOS DE CÂNCER DE PELE NÃO MELANOMA ATENDIDOS NO HOSPITAL UNIVERSITÁRIO DA UNIVERSIDADE FEDERAL DO PIAUÍ/ Anatomopathological study of non-melanoma skin cancer treated at the University Hospital of the Federal University of Piauí
Authors: Alves de Castro João Victor , De Deus Moura Rafael , Lopes de Pádua Moura Carla Riama , Reis Ferro Braga Aline , Marques Campelo de Carvalho Andressa , De Carvalho Paulo Marcos Guilherme
Published: January 2021

O câncer de pele não melanoma (CPNM)  inclui, principalmente, o carcinoma basocelular (CBC) e carcinoma espinocelular (CEC). É o tipo mais incidente no Brasil em ambos os sexos, apresentando bom prognóstico. Trata-se de um estudo transversal que analisou o perfil clínico e histopatológico dos CPNM em um centro de referência em dermatologia no período de julho a dezembro de 2017. Realizou-se a revisão, por um dos patologistas do estudo com experiência em dermatopatologia, de todas as lâminas histopatológicas referentes aos casos e os dados complementares foram obtidos através de revisão dos prontuários. Foram encontrados 104 casos, distribuídos em 85 pacientes. 47,4% possuíam entre 60 e 79 anos, e 80,7% localizavam-se na região da cabeça e do pescoço. Os casos de CBC corresponderam a 89,4%, com o subtipo nodular predominando em 75,3% destes casos. 10,6% do total de casos corresponderam a CEC, apresentando grau moderadamente diferenciado em 65,6% desses. O procedimento de escolha para tratamento foi cirurgia excisional, em 96,2% dos casos. Observamos que 50% dos CBC e mais de 75% dos CEC apresentavam margens cirúrgicas abaixo das recomendações da maioria dos consensos, alertando para o possível aumento do risco de recidivas e para a importância de seguimento clínico rigoroso desses pacientes.
ESTRATEGIAS DE ENSEÑANZA Y NIVEL DE SATISFACCIÓN ACADÉMICA DE ESTUDIANTES DE LA ESCUELA PROFESIONAL DE TURISMO Y HOTELERÍA DE LA UNIVERSIDAD CATÓLICA DE SANTA MARÍA, AREQUIPA, 2018.
Authors:   UNIVERSIDAD CATOLICA DE SANTA MARÍA, Wagner Carrillo Yudy Djanira , Beltrán Molina Rosa Patricia ,   UNIVERSIDAD CATOLICA DE SANTA MARÍA
Published: January 2021

The purpose of this research is to determine the relationship between teaching strategies and the level of the students’ academic satisfaction at the Professional School of Tourism and Hospitality at the Catholic University of Santa Maria; the population or universe is made up of 157 students enrolled in the Pair Semester 2018, the study is of a non-experimental, cross- sectional correlational design and explanatory level, basic type with a quantitative approach, developed in the area of university higher education; applying two questionnaires; the first one, is a questionnaire about the teaching strategies and the second one is a questionnaire about the students’ academic satisfaction in the PST&H, both instruments validated by experts’ judgment with a result of applicability, the reliability was determined using the Alpha de Cronbach Coefficient, obtaining a result of 0.98 and 0.96 respectively for each variable and the Chi Square statistical, finding that the most used strategies by teachers are those focused on the transmission of information with 37.6%, considered as traditional teaching strategies and the highest percentage of academic satisfaction is related to the level of student self-realization with 51%; as a conclusion we have that there is a positive relationship between teaching strategies and the students’ academic satisfaction at the Professional School of Tourism and Hospitality at the Catholic University of Santa Maria (P<0.05; according to tau b de Kendall there is a moderate correlation π=0.51). Keywords: teaching strategies, academic satisfaction, university students, higher education and educational quality.
Programas de atención médicos comunitarios en la prevención de enfermedades de transmisión sexual
Authors: Yaguana Martínez Yadira Vanesa , Zambrano Zambrano María Dolores , Cedeño Zambrano Zayda Victoria , Farias Cevallos Viviana Rocio , Bravo Bonoso Delia Georgina , Delgado Bernal Doris Susana , Pila Cando Kleber Marcelo , Real Jiménez Mónica Jazmine , Fernández Aguilar María Emilia , Guaranda Moreira Johana Elizabeth
Published: January 2021

Las medidas de la salud y la calidad de vida implementadas a nivel sanitario en el mundo entero han llevado al desarrollo de investigaciones científicas dirigidas a analizar, interpretar y determinar cuáles son los factores de riesgo que inciden para que determinadas patologías se conviertan en un problema de salud pública y su prevalencia aumente cada día más. En virtud de esto, se hace necesario resaltar que existe la necesidad de intensificar y expandir programas médico comunitario que busquen reforzar el control adecuado y permanente de los factores que inciden en determinadas patologías, los cuales comprenden aspectos específicos de los estilos de vida, tales como el conocimiento acerca de la enfermedad, la dieta, los patrones de actividad física, hábitos inadecuados y el consumo de alcohol, aspectos estos que han sido representativos marcadores de efectos importantes de morbilidad y mortalidad, especialmente si se encuentran aunados a una enfermedad en el paciente. Entiéndase a través de estos señalamientos que, implementar programas para la salud representa un componente fundamental de la promoción de medidas preventivas dirigidas a establecer la transmisión de conocimientos y de informaciones tan necesarias para la formación de hábitos saludables y cambios en los estilos de vida que logren minimizar los riesgos y estilos de vida inadecuados desarrollados por las poblaciones en su día a día, incrementándose con ello, la morbi mortalidad de aquellas enfermedades que representan un problema de salud pública a nivel mundial. De aquí, la importancia del presente libro, el cual ha sido realizado con gran dedicación, buscándose con el mismo orientar tanto a profesionales de la salud, como a personas asociadas al nivel sanitario para que sean estos conocedores de la importancia que tienen las intervenciones médicas comunitarias a nivel mundial.
O GESTO INTERPRETATIVO DO(A) PESQUISADOR(A): Apontamentos teórico-metodológicos para análises de práticas sociais
Authors: Nascimento Clebemilton Gomes
Published: January 2021

Neste texto, parto do entendimento de que todo processo de construção, gestão e difusão do conhecimento está atravessado pela linguagem, sendo, portanto, uma dimensão estruturante no traçado teórico-metodológico de qualquer investigação científica bem como na atitude interpretativa e crítica do(a) pesquisador(a). Com isso, proponho uma reflexão sobre o gesto interpretativo da pessoa pesquisadora na análise textual de informações discursivas em práticas de pesquisas cuja matéria prima são textos de diferentes gêneros e tipos. Para tanto, desde a minha experiência como professor-pesquisador, proponho aproximações e contribuições de diversos campos do conhecimento, principalmente dos Estudos Críticos do Discurso, abordagem teórica a partir da qual tenho operado nas minhas análises,  a partir de  uma inflexão experimental, multidisciplinar, multirreferencial e polilógica da linguagem na/para a pesquisa. Dessa forma, a linguagem é pensada enquanto teoria e dispositivo analítico na modelagem do conhecimento. Para além disso, essa reflexão ensaia flertes, ainda incipientes, com os estudos da cognição no saber-fazer do analista cognitivo.
Rosguard in decision of issues of domestic policy
Authors: Vinogradov Vadim , Rostovtsev Sergey
Published: January 2021

The article examines the issues of the theory of state and law, the place and role of the troops of the National Guard of Russia in the system of functions of the modern Russian state, the problems of legal support for the activities of the National Guard of Russia in ensuring the national security of Russia.
IMPLICATIONS OF INTERNET ADVERTISING ON NEW MEDIA ENTREPRENEURSHIP: A BOON OR BANE?
Authors: Agboola AbdulhameedKayode , Mustapha Lambe
Published: January 2021

Internet advertising implies advertising using the internet as a platform. It is a marketing strategy which deals with attracting web traffic and delivering marketing messages to appropriate targets using the internet as a medium. Internet advertising has no doubt positively revolutionized the sector of commerce. It has simplify and made more effective the communication between entrepreneurs and their potential customers. This study discusses among other things the advantages of internet advertising which include: reaching significantly more people than the traditional advertisement media at a cheaper rate for large scale businesses especially the international ones. But on the contrary, internet advertising can expose marketing materials of a competitor which can be copied by anyone and use for purposes detrimental to such competitor’s business. This paper argues that since there is no censorship on the internet, it is difficult or at worst impossible to scrutinize and regulate advertisements online making teenagers and young children to be vulnerable. This study proffers that one major threat that internet advertising may need to combat is policy. It is not that internet advertisement is illegal, but the freedom associated with it becomes limited when policies are formulated day by day. Also, from another perspective, the internet itself has become a threat to internet advertising due to emerging measures to curb and control unsolicited messages and adverts to be specific. This paper concludes that the level of optimism as regards the future of internet advertising is on the rise as it responds rapidly to technological advancement. There seem to be a very bright light at the end of the tunnel as internet is reaching to the nooks and crannies of the globe. So far, internet advertising has the highest ROI and is promising to improve, and at worst to maintain the status quo. Therefore, there is no doubt that alongside potential challenges, internet advertising holds for a bright future.
RISK FACTORS OF PROTEIN-ENERGY MALNUTRITION DEFICIENCY AMONG CHILDREN UNDER FIVE YEARS AT MUSI INTERNAL DISPLACED PERSONS CAMP HOUSEHOLD SURVEY – NYALA LOCALITY – SOUTH DARFUR STATE 2011
Authors: Ahmed M.Hussein , Adam Dawria , Salim Abdelbasit. M. Burma , Abdallah Belal
Published: January 2021

We  conduct  this  study  to  study risk factors of   protein energy malnutrition  Among Children Under Five years .This  study was conducted in Nyala  Locality in south  Darfur  State in  Sudan. Cross-sectional descriptive study to measure the Prevalence of protein energy malnutrition. This study designed to cover (n=402 child).
Idiopathic granulomatous mastitis in a pregnant woman
Authors: Souza Israel Moreira Ramos de , Matta Francisca Indira Beltrão Colaço Costa da , Santos José Ismair de Oliveira dos , Barreto Thayrone de Miranda
Published: January 2021

Introduction: Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease of unknown etiology. It was described in 1972 by Kessler and Wolloch, who reported cases of granulomatous lobulitis with no established relationship with trauma, foreign body, or specific infection. This study aimed at reporting a case of IGM in a pregnant patient. Clinical case: A 36-year-old pregnant woman, with a gestational age of 27 weeks, was admitted with a complaint of right breast pain for 7 days. She denied comorbidities. Clinical examination showed a dense area in the junction of the right inner quadrants, associated with mild hyperemia without signs of fluctuation. Lymphadenopathy was not identified. Ultrasound revealed a non-homogeneous fluid of 4.9x1.7x5.2 cm in the right upper inner quadrant, with a consequent surgical approach and collection of fragments for analysis. Cultures with antibiogram and for fungi and the venereal disease research laboratory (VDRL) tested negative. Histopathological examination showed a chronic inflammatory process with abundant granulation tissue and isolated giant cells, suggesting granulomatous mastitis. Corticosteroid therapy was indicated after the birth, with prednisone 40 mg/day for 3 months, with complete resolution of the symptoms. Discussion: Usually, IGM affects women aged 17 to 42 years. Recent history of pregnancy is common, with identified cases ranging from 2 months to 15 years after the last delivery, rarely occurring during gestation. It manifests as a breast mass of 0.5 to 9 cm in diameter, often unilateral and on the left side. Signs of inflammation and local lymphadenopathy can also be identified. Mammography is not ideal for detecting IGM, with findings of low specificity, and false negatives are frequent in dense breasts. The most frequent ultrasound findings are irregular hypoechoic mass and tubular hypoechoic lesion. IGM can be confirmed by detecting a histological pattern of chronic granulomatous lobulitis, non-caseating granuloma with infiltration of histiocytes, few polymorphonuclear cells, and multinucleated giant cells. Ruling out syphilis, fungi, and breast tuberculosis is important. The recommended treatment is excisional biopsy, preferably a wide excision. However, surgical management has a negative cosmetic impact and is associated with up to 50% of cases of persistence and recurrence of the disease, in addition to complications such as abscesses, fistulas, and ulceration. Corticosteroids are an effective option for controlling the disease, but active surveillance can also be chosen. Considering the above, we underline the importance of early diagnosis with appropriate scientific and technical foundations to provide a better prognosis for patients.
Desmoid-type fibromatosis of the breast in a male patient
Authors: Melo Márcia Portela , Magdalena Luiza Guimarães de , Cavalheiro José Antonio Crespo , Graudenz Márcia Silveira , Brazan Murilo de Lima
Published: January 2021

Introduction: The desmoid breast tumor was first described in 1832, by Mac Farianec. It originates in the parenchyma or in the thoracic wall muscles. In the presence of a breast implant, the origin can be related to the fibrous capsule. Primary breast fibromatosis is rare, less than 0.2% of the lesions. It is more common among women at reproductive age, with slow and progressive growth. It tends to be locally aggressive and present recurrence after resection, without metastatic potential. In imaging examinations, they simulate carcinomas. Case report: A 65-year old male patient complaining of palpable nodule in the left breast, with no family history of breast cancer or inherited genetic syndromes. Imaging examinations showed an irregular nodule, with spiculated margins, high density and posterior acoustic shadowing, measuring 1.4 cm (BI-RADS® 5). Percutaneous biopsy of the lesion favored desmoid-type fibromatosis. After sectorectomy, anatomopathological and immunohistochemical examinations confirmed the diagnosis. Discussion: The etiology and physiopathology of these lesions are still not totally known, and it is uncertain whether or not they are part of the abdominal and extra-abdominal fibromatosis spectrum. There are differences in the hormone receptor profile and recurrence rate. Cell proliferation occurs after trauma, hormone stimulation or genetic determination. It can rarely be associated with Gardner’s syndrome or familial multicenter fibromatosis. The treatment consists of surgical excision of the lesion, and radiotherapy can be used in extensive or unresectable tumors. The use of hormone, cytotoxic or anti-inflammatory agents is considered, according to etiology. Tamoxifen can be efficient in negative hormone receptors through the synthetic induction of transforming growth factor beta 1 (TGF b1) through fibroblasts and apoptosis. The highest local recurrence rate occurs in 3 years, when quarterly surveillance is recommended.
Evaluation of sexual performance in women treated for breast cancer
Authors: Sposito Letícia , Vitorino Caroline Nakano , Bortolotti Gislaine Maria Fontanetti , Motoki Andre Hideo , Buttros Daniel de Araújo Brito
Published: January 2021

Objective: To assess the sexual performance (SP) pattern in women treated for breast cancer (BC). Methods: Cross-sectional study with 33 women treated for BC. We included women aged between 35 and 66 years, with histopathological diagnosis of breast cancer, who already concluded the initial oncological treatment (surgery, chemotherapy and radiotherapy), in stage IV, assisted in the Unified Health System. They signed the informed consent form. Oncological data, such as staging, type of surgery, type of adjuvant treatment and follow-up time were collected through the analysis of medical records. The women were submitted to individual interview to assess SP, and the Female Sexual Quotient (FSQ) questionnaire was applied. The FSQ is formed by 10 objective questions that score from 0 to 5 points according to the answer: never, infrequently or rarely, sometimes, nearly 50% of the time, most of the time, always. The final score is defined by the sum of points multiplied by 2, and the SP is classified as: poor (0-20), unfavorable (22-40), fair (42-60), good (62-80), and excellent (82-100). Mean/standard deviation and percentage rates were used for statistical analysis. The study was approved by the Research Ethics Committee, Plataforma Brasil/CAAE: 02241618.1.0000.5381. Results: The mean age and oncological follow-up were 55±11 years and 4.5±2 years, respectively. The most prevalent oncological data were: 35% were in stage 2; 84% were submitted to conserving surgery; 95%, to radiotherapy; 65% underwent chemotherapy; and 80% were on endocrine therapy. Regarding sexual performance, 62% spontaneously think about sex; 35% are always interested in sex; and 54% are always stimulated by the “foreplay”. During the sexual relation, 32% always get lubricated; 45% become more stimulated when the partner is aroused; 45% always relax their vagina appropriately; 45% never feel pain; 52% always get involved without distraction; 51% always reach orgasm; and 42% always wish to repeat sexual relations in the following days. After calculating the final score, the conclusion was that 6% have poor sexual performance; 20%, unfavorable; 20%, fair; 38%, good; and 16%, excellent. Conclusion: Most women treated for breast cancer present with sexual performance classified between good and excellent, according to the Female Sexual Quotient.
Utilization of plants as food source from Sebaju village forest, Nanga Kebebu village, Nanga Pinoh District, Melawi Regency
Authors: Diba Farah , Sholihin Muhammad , Nurhaida Nurhaida
Published: January 2021

Forests has a role in supporting food security programs. Sebaju Village Forest, Nanga Kebebu Village, Nanga Pinoh District, Melawi Regency is a village forest area that has the potential of non-timber forest product, one of which is that there are many plants that can be used as food for daily living needs. The research objective was to explore local knowledge of the community and to make an inventory of the types of plants used as food by the communities around the Sebaju village forest, Nanga Kebebu village, Melawi regency, as well ass to describe how to uses and process plants that are used as food by the community. The research method was purposive sampling and data collection was carried out by in-depth interviews with the community in Nanga Kebebu village. The data were analyzed descriptive qualitative in order to obtain a systematic and accurate picture. The results found 58 plant species consisting of 31 families, these plants were dominated by the Anacardiaceae family (8 species). Arecaceae and Moraceae (5 species), Sapindaceae, Phyllanthaceae, Myrtaceae, and Fabaceae (3 species), while one other family each has 1-2 species. The most dominant plant habitats were trees with 40 species (68.96%), 8 types of herbs (13.79%), 4 types of shrubs (6.89%) and the least were lianas and 3 types of shrubs. (5.17%). The part of the plant that was used the most was the fruit, namely 44 species (75.38%), 8 types of leaves (13.79%), while the parts of the plant that were least used were 2 types of tubers (3.45%), 2 types tubers (3.45%), 1 flower (1.72%), 1 seed (1.72%). The largest group of foodstuffs is fruit as much as 40 types (67%), 12 types of vegetables (20%), while the lowest is 3 types of drinks (5%), 3 types of spices (5%), and 2 tubers type (3%). The most widely used food crop processing method is directly used 33 types (56.90%), 10 types of boiled (17.24%), 6 types of sauteed (10.34%) and 5 types of chili sauce (8.62%), Meanwhile, the least used processing methods were 2 types of frying (3.45%) and 2 types of drying (3.45%). Based on their growth status, the highest growth was in the wild, consist of 34 species (59%), and the lowest was cultivated by 24 species (41%) that grew in the Sebaju customary forest area, Nanga Kebebu Village, Nanga Pinoh District, Melawi Regency. Sebaju village forest has high biodiversity as food plant and local knowledge of te community in the use of plants in the forest area makes conservation efforst better because the community strives to be able to make a sustainable management of food from forest.ÃÂ
ARCHITECTURAL PERIODS OF THE UKRAINIAN NON-FORMAL EDUCATION
Authors: VASYLCHENKO DARIA
Published: January 2021

The article considers three conditional formation periods of the extracurricular education in Ukraine (before the revolution of 1917, the Soviet era, the period of independent Ukraine). The features of extracurricular institutions of each period, the formation purposes, the main tasks of the periods, the implementation forms of extracurricular education are studied. The description of Ukrainian landmark buildings of each period is given. The modern problems such as the problem of moral and physical obsolescence of educational spaces, private establishments control system, the lack of regulatory documents for extracurricular institutions design, difficulties related to functioning of extracurricular education system in the structure of united territorial communities and the fate of abandoned cultural centres are reviewed. Development trends of extracurricular institutions of Ukraine are revealed. The question of the extracurricular educational system formation in foreign countries is touched upon and the specifics of foreign extracurricular educational systems are revealed.
Resenha - 10 Lições sobre Bourdieu
Authors: Macedo Rodolfo Alves de
Published: January 2021

Resenha do livro: MONTEIRO, José Marciano. 10 Lições sobre Bourdieu. Petrópolis: Vozes, 2018, 136 p.
A Novel Structure of Highly Interpretable Fuzzy Rules Extraction
Authors: Ahouz Fatemeh , Golabpour Amin
Published: January 2021

Introduction: Extracting effective rules from medical data with two indicators of accuracy and high interpretability is essential to increase the accuracy and speed of diagnosis by specialists. As a result, the production of medical assistant systems that are able to detect the rules governing the data plays a vital role in early detection of the disease and thus increase the chances of treatment, disease control and maintaining the quality of life of patients.Material and Methods: In this paper, a system of automatic extraction of rules from medical data by a new hybrid method based on fuzzy logic and genetic algorithm is presented. Genetic algorithms are used to automatically generate these rules. The Parkinson UCI dataset including 195 records and 23 variables was used to evaluate the proposed method based on the criteria of interpretability, accuracy, sensitivity and specificity.Results: The evaluation of the proposed model on the Parkinson's dataset was the accuracy of 84.62%. This accuracy is supported by 4 fuzzy rules with an average rule length of 2 and using 7 linguistic terms extremely low, very low, low, normal, high, very high and extremely high. All fuzzy membership functions that represent each term have the same width.Conclusion: The proposed method, based on the three criteria of low number of rules, short rule length and symmetric membership functions with equal width for all variables, is quite suitable for automatic production of accurate and compact rules with high interpretability in medical data. . A 90% dimensionality reduction in the experimental evaluation showed that this model could be used to implement real-time systems.
Medical Informatics Applications in COVID-19 Crisis Control: Protocol for Systematic Literature Review
Authors: Eslami HassanAbady Saeed , Ganjali Raheleh
Published: January 2021

Introduction: SARS-CoV-2 has disseminated globally, and COVID-19 has been labeled as a public health emergency of global concern by the World Health Organization. Since 2019-nCoV (2019 new coronavirus) has a long incubation period and high infectivity, e-Health and its subsets in medical informatics (MI) have evolved as a suitable solution to enable the continuity of health services delivery. Also, new health care models are required during the COVID-19 pandemic. The proposed systematic review aims to examine and summarize evidence related to medical informatics applications in COVID-19 crisis, as evidence-based approaches. Methods and Analysis: A research team consisting of experts in the fields of medical informatics and systematic review methods were guided this review according to the Cochrane Handbook and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) reporting guidelines. PubMed and Scopus databases were searched. Eligibility criteria for including studies reviewed was randomized and non-randomized controlled trials published in English language. Articles performed on medical informatics applications in COVID-19 pandemic during 2019-2020 were identified. Two independent reviewers will assess articles eligibility and extract data into a spreadsheet using a structured pilot-tested form. Collected data and evidence will be synthesized using a thematic synthesis approach. The risk of bias will be assessed in all included studies using appropriate tools. Results: The literature search led to the identification of a total of 1882 and 854 articles retrieved from the PubMed and Scopus databases, respectively. After removing duplicates, 2716 articles remained and underwent title and abstract screening process. Conclusion: This systematic review aims to identify the applications of medical informatics in COVID-19 pandemic. To the best of our knowledge, this review is the first attempt undertaken to develop an evidence-based method using a systematic review approach.
Levels of Stress and Characteristics of Perfectionism in CSD Students
Authors: Beck Ann , Verticchio Heidi
Published: January 2021

An electronic survey was sent to the Midwest Clinic Directors’ Listserv requesting they distribute it to students in their CSD programs. The survey collected information about demographics, and students’ top three stressors and stress management practices. Students were also asked to complete the 10-item Perceived Stress Scale (PSS; Cohen, 1994) and the Almost Perfect Scale-Revised (APS-R; Slaney, Rice, Mobley, Trippi, & Ashby, 2001). A total of 278 CSD undergraduate and graduate students from 15 Midwest institutions responded to the survey. No differences were found between undergraduate and graduate responses to the PSS and the APS-R. Twenty-six percent of the respondents were classified as nonperfectionists, 33% as adaptive perfectionists, and 41% as maladaptive perfectionists. A relationship was found between perceived stress and perfectionism such that respondents with higher levels of perceived stress tended to be classified as maladaptive perfectionists and those with lower levels of perceived stress tended to be classified as adaptive perfectionists. Similarities and differences were found between undergraduates and graduate students in terms of stressors; close to 45% engaged in a stress management practice. Importance of such practices is discussed.