bluuebunny/crossref_metadata_2025 huggingface dataset:
Case of Recurrent Episode of Schizoprenia Paranoid in Pregnant Woman
Authors: Setiobudi Karen Delicia , Soetjipto Soetjipto , Era Catur Prasetya
Published: May 2023

AbstractIntroductions: Pregnancy is a stressor to women, in terms of biological as well as psychological. For individuals who previously received medication for schizophrenia in the past, it can be a triggering factor for the relapse of the illness. Here we describe a case of a pregnant woman who experiences a relapse in pregnancy. Case: The patient was a 40-year-old pregnant woman, brought to the emergency room after attacking her father by stabbing her father’s head with a knife. She was suspicious of her dad’s gaze at her. She was hostile towards healthcare workers when being examined. For her pregnancy, consultation with the Obstetric and Gynaecology department had been done to ensure that she and her baby were taken care of while being treated in the psychiatry ward. Discussions: The patient was diagnosed as having paranoid schizophrenia recurrent episodes. There was no complication found in her pregnancy, and she was scheduled for Sectio Caesarean as she was not mentally fit to do vaginal delivery. The psychiatric approach to the patient was atypical antipsychotic along with supportive psychotherapy. Psychoeducation and family therapy were also done to ensure that the patient’s family understand the illness and the importance of compliance with the medication. Conclusions: Pregnancy is one of the factors that lead to the relapse of schizophrenia in patients with a history of mental illness. Holistic treatment is needed to treat the patient to prevent the relapse of the illness.
Facing challenges with hope: universal immune cells for hematologic malignancies
Authors: Wang Yuqing , Huang Ruihao , Wang Zheng , Xiong Jingkang , Wang Xiaoqi , Zhang Xi
Published: May 2023

Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation (allo-HSCT) has been widely implemented to treat hematologic malignancies. However, graft-versus-host disease (GVHD) and complications of immunosuppressive drugs after allo-HSCT are the main causes of non-relapse mortality and a poor quality of life. In addition, GVHD and infusion-induced toxicity still occur with donor lymphocyte infusions (DLIs) and chimeric antigen receptor (CAR) T-cell therapy. Because of the special immune tolerance characteristics and anti-tumor ability of universal immune cells, universal immune cell therapy may strongly reduce GVHD, while simultaneously reducing tumor burden. Nevertheless, widespread application of universal immune cell therapy is mainly restricted by poor expansion and persistence efficacy. Many strategies have been applied to improve universal immune cell proliferation and persistence efficacy, including the use of universal cell lines, signaling regulation and CAR technology. In this review we have summarized current advances in universal immune cell therapy for hematologic malignancies with a discussion of future perspectives.
Interview with Mohsin Hamid
Authors: Karim Khan Saba
Published: May 2023

In this exclusive interview between Pakistani authors Saba Karim Khan and Mohsin Hamid, Mohsin Hamid discusses his complex relationship with the concept of home.
"Lesbian with the attributes of a man: Is a trans history of male masochism possible?
Authors: Szpilka Jay
Published: May 2023

This article is an attempt at presenting a case for thinking about male masochism—from its conceptual inception in late 19th century sexology, to its contemporary framing as a sexual practice falling under the umbrella of BDSM—as having close historical connections with the history of transness, and trans femininity in particular. In order to do so, I provide an overview of the way that the idea of male masochism as femininely gendered has been variously posited, contested, and disavowed across 130 years of masochism’s discursive history. Finally, I argue for the necessity of histories of trans femininity to accept speculative approaches as a valid way of thinking about the possibilities of trans history, and ask what political ends have been served by the “cisisfication” of masochism and practices of sexual submissiveness, which is rendering them culturally legible as having nothing to do with their practitioners’ gender.
Queering the Fens: an exploration of land, supernatural, folklore and queer reproduction as art making
Authors: Chantry James
Published: May 2023

This essay refers to a body of work and research that considers the connections and intersections of the supernatural and Queerness. The project began with an exploration of ghost stories and their connection to repressed sexuality and identity, mediumship and its relationship to transgression of gender. This revealed notions of supernatural Queer male birth and how making art can embody this. A specific personal geographic location: the Lincolnshire Fens became important in its: liminality, landscape, wealth of folklore and connection to Queerness, politics, and the queer body’s relationship to the land. Working  in a transdisciplinary manner I have produced charged and evocative time based media, using methods of creation related to mediumship and the  supernatural. Particularly: performance, sculpture and drawing, woven into video installations. I have proposed speculative queer futures that challenge  hegemony, examine queer identity and celebrate the downright weird.
Multilingualism in Akwaeke Emezi’s Freshwater and Zahra Patterson’s Chronology
Authors: Zlámalová Karolína
Published: May 2023

Multilingualism is one of marginalised authors’ strategies to express their stories and identities when writing in what bell hooks labelled ‘the oppressor’s language’. It allows them to navigate language imbued with contradictions: the language that connects and provides terminology for some marginalised  identities while being infused with various oppressive regimes. This article discusses the forms and roles of multilingualism in two queer life-writing texts:  written in English and interwoven with African influences, Akwaeke Emezi’s Freshwater (2018c) is an autobiographical novel; Zahra Patterson’s Chronology  (2018) is an experimental autobiographical essay. The scope and the forms of multilingualism differ: in Chronology, a significant part of the text is written in  Sesotho; in Freshwater, the passages in Igbo are comparably scarce. Emezi, however, also adopts a non-Western register in the English passages as another  strategy of postcolonial writing ‘in character’. The article argues that while the concrete strategies vary, the authors employ multilingualism for similar political  and aesthetic purposes: they utilise it to challenge the presumed universality of the Western conceptualisations of identity, gender, and sexuality, to express  hybridity and heterogeneity of the narrated identities, and for its potential to create intimacy in the language.
Queering the Schizophrenic Body: Re-orientated nerves
Authors: Kupferschmidt Phyla
Published: May 2023

In this paper I explore how some insights about queer embodiment can be applied to the subtleties of psychotic experience, introducing a recovery-oriented  dialogue between a queer-phenomenological and phenomenological-psychiatric approach. More specifically, I show how some concepts from Sara Ahmed can  complement the ipseity-disturbance model, with which Louis Sass and his colleagues have re-introduced phenomenological psychiatry to mainstream  schizophrenia research.
THE RELATIONSHIP BETWEEN TERMINAL MONITORING DEVICE INSTALLATION IN RESTAURANTS AND AN INCREASE IN TAX REVENUE IN SURAKARTA FROM 2014 TO 2021
Authors: Laoli Agustina Fati Trinitasia , Hanung Triatmoko  , Asaprima Putra Kurnia  , Trisninik Ratih Wulandari
Published: May 2023

The purpose of this research is to analyze the effect of installing Terminal Monitoring Device (TMD) in restaurants on the increase in tax revenue in Surakarta City for 2014—2021, its contribution to regional taxes and Regional Original Income (Pendapatan Asli Daerah/PAD), as well as the obstacles. The method applied in this research is a descriptive quantitative approach. This research used primary and secondary data. Primary data include interviews with the Regional Revenue, Financial and Asset Management Agency (Badan Pendapatan Pengelolaan Keuangan dan Aset Daerah/BPPKAD) of Surakarta, while secondary data include reports on the realization of restaurant tax revenues, reports on the realization of regional taxes, reports on the realization of PAD, and data on the number of restaurants taxpayers in Surakarta. The results of this research show that the installation of TMD did not have a significant impact on increasing restaurant tax revenues in Surakarta City and increasing the restaurant tax contribution to regional taxes and PAD during 2018—2021. Several technical and non-technical factors cause the non-optimal installation of TMD to increase restaurant tax revenues in Surakarta.
Microencapsulation of Garlic Oil with Gelatin and Maltodextrin Encapsulant Using the Coacervation Method
Authors: Fitriyani Elisa , Damayantia Anastasia Devina , Ruwaidaha Listia Aulia , Nabila Shifa Annisa , Fadilah Fadilah
Published: May 2023

ABSTRACT.  Garlic Oil is widely used as a raw material for fragrances with volatile active compounds at room temperature. It is easily affected by environmental changes and this problem can be solved by microencapsulation using coacervation methods to protect active compounds. Garlic Oil was encapsulated using gelatin and sodium alginate as coating materia with glutaraldehyde as the crosslinking agent. The purpose of this research was to study the effect of the composition of polymers and the mass of garlic oil on encapsulation characteristics. The resulting microcapsules were analyzed using a digital microscope, SEM, FTIR, and encapsulation efficiency. The result showed that microcapsules have an irregular shape with a textured surface. The FTIR spectrum showed an indication of garlic oil with allicin content in microcapsules. The encapsulation efficiency is  34.23%  with a yield of 29.43%.
Special Issue on Human Digital Twin Technology
Authors: Tada Mitsunori , Inamura Tetsunari
Published: May 2023

With the advancement of information technologies such as the Internet of Things and artificial intelligence, cyber-physical systems are being introduced into society. At the core of these systems is the digital twin, a computer model (twin) of a physical entity built in cyberspace for simulation-based prediction.

Currently, the digital twin mainly targets artificial objects, such as aircraft engines and factories. However, if it can be extended to humans, it could lead to the realization of human-machine cooperative systems and health promotion services, thereby solving social issues stemming from the aging of society. However, humans are the weakest link in the system, and many technical problems remain to be solved, such as realizing the measurement, modeling, and prediction of human behavior, if the human digital twin is to become reality.

This special issue contains 9 papers on developing essential technologies for the human digital twin and constructing human-machine systems for specific applications. The topics covered include learning algorithms, motion measurement and analysis techniques, human perception, system development, and platform software for system development. These clearly show that cross-disciplinary efforts are essential to the realization of the human digital twin.

We thank the authors of the papers submitted for this special issue. We are confident that the information provided by the authors is suggestive and informative for both specialists and non-specialists alike. We also sincerely appreciate the efforts of the reviewers. Their contributions helped to make this special issue possible. We hope that this special issue will catalyze sharing across the boundaries of research fields along the path to realizing a human digital twin.
Motion Measurement and Analysis for Functional Independence Measure
Authors: Matsuura Shino , Hirata Kazuhiko , Kimura Hiroaki , Iwamoto Yoshitaka , Takahashi Makoto , Endo Yui , Tada Mitsunori , Maruyama Tsubasa , Kurita Yuichi
Published: May 2023

An appropriate physical functionality status assessment is necessary after rehabilitation to determine the level of assistance required by the patient and the efficacy of rehabilitation. The effectiveness of rehabilitation can be determined by computing a functional independence measure (FIM) score. The FIM score measurement process evaluates the amount of assistance associated with activities of daily living; however, it is influenced by evaluator subjectivity and can vary for the same patient assessed by different evaluators. Furthermore, it is time-consuming and laborious because of the large number of component items. Therefore, a new evaluation system that is easily implementable and based on objective criteria is needed. Several machine learning techniques have been suggested for evaluating the progress of rehabilitation in an objective manner, and their efficacy has been proven. However, the FIM score includes complex movement items, necessitating the evaluation of factors from multiple angles. In this study, a method for estimating FIM values using machine learning was investigated to evaluate the effectiveness of rehabilitation objectively. A simple exercise measurement experiment was conducted, and a musculoskeletal model was used to analyze the data to obtain movement and other mechanical indices, and these were subsequently used as features of machine learning. Based on the FIM values, an estimation experiment was conducted in three groups: independent, modified independent, and assisted groups. The statistical approaches of random forest and logistic regression were used in conjunction with a support vector machine for FIM estimation. The highest accuracy was estimated to be approximately 0.9. However, the accuracy varied with each method and item; the lowest accuracy was approximately 0.3. Statistical analysis showed clear differences in the indicators, with significant differences between the groups. These differences were considered to increase the accuracy of FIM estimation. Additionally, the accuracy of some items was improved by changing the feature values used. The best results were obtained when only the joint angle was used for two items, joint torque and muscle strength were used for seven items, and all indicators were used for two items. This suggests that a comprehensive evaluation, including that of joint torque and muscle strength, is effective for estimating FIM score.
Effect of Perspective and Visuo-Tactile Feedback in Virtual Reality-Based Posture Learning
Authors: Hanashima Ryo , Tokuda Takumi , Mochimaru Masaaki , Ohyama Junji
Published: May 2023

Posture learning is required in rehabilitation and in sports such as yoga and martial arts. Virtual reality (VR) systems are being used to learn posture by superimposing the postures of the learner and instructor in cyberspace using avatars. In this study, we examined whether the presented perspective of the avatar (first-person vs. third-person perspective) and visuo-tactile feedback (tactile correct feedback + visual feedback vs. tactile incorrect feedback + visual feedback vs. visual only feedback) are effective for the posture learning. The results of an experiment (N = 24) suggested that use of the third-person perspective may result in accurate learning of the head position as compared with first-person perspective. Visuo-tactile feedback was found to improve the subjective rating on the ease of learning, while the presentation method in which tactile feedback is given when body position is correct was found to be more effective than tactile feedback given when body position is incorrect. The sense of agency was maintained at a high level under all conditions for perspective and visuo-tactile feedback and may have improved the learning accuracy of posture. The findings of this study are expected to contribute to the design of effective perspective and tactile presentation in VR-based motor learning.
Digital Twin of Experience for Human–Robot Collaboration Through Virtual Reality
Authors: Inamura Tetsunari
Published: May 2023

The keyword “human digital twin” has received considerable attention in recent years, and information technology has been developed in healthcare and sports training systems to guide human behavior to a better state. In contrast, from optimizing the production and maintenance processes of industrial products, which is the origin of the term “digital twin,” intelligent robot systems can be interpreted as a mainstream of digital twin. In other words, assistive robots that support humans in their daily lives and improve their life behavior require the integration of human digital twin and conventional object digital twin. However, integrating these two digital twins is not easy from the viewpoint of system integration. In addition, it is necessary to encourage humans to change their behavior to provide users with subjective and immersive experiences rather than simply displaying numerical information. This study reviews the current status and limitations of these digital twin technologies and proposes the concept of a virtual reality (VR) digital twin that integrates digital twins and VR toward assistive robotic systems. This will expand the experience of both humans and robots and open the way to the realization of robots that can better support our daily lives.
Therapeutic Communication in Trauma Recovery for Students Surviving of Sexual Violence
Authors: Orwela Citra
Published: May 2023

Sexual violence is one of the unresolved issues up to now. Several efforts have been made by the government such as providing LPA protection and safe houses in several areas in order to minimize the case of sexual violence. However, this issue has still been found in the community, in the area of City and District of Kediri. The research used a multi case study approach by conducting interviews and observing sexual violence survivors and associates from NGOs KIBAR and WCC Kilisuci. The researcher was actively participated and involved in mentoring activities. It was found that there were 3 stages of therapeutic communication; The first stage is the pre-counseling process in the form of collecting data from survivor reports, survivors' friends or survivors' families. The second stage, the counseling process is carried out by taking a persuasive approach to build the level of trust of the survivors and their families towards the assocaites volunteers. The third stage, post mentoring process for recovery communication after all case counseling processes are completed.
The Prevention of Sexual Violence Against Women Based on Minangkabau Local Wisdom
Authors: Fithri Widia , Yulika Febri , Ermagusti Ermagusti
Published: May 2023

This paper aims to explain the local wisdom used in preventing sexual violence against women in West Sumatra Province. This type of research uses a PAR approach through management planning, actuating, organizing, and reflecting. Data were analyzed descriptively using data reduction, display, and verification. The findings of this study show that Aisiyah organization used the local wisdom to change people’s mindsets in seeing victims of sexual violence as figures that need to be strengthened together. The Minangkabau traditional order, which is based on customs and religion, is a comprehensive guide to governing people’s lives, particularly in the Minangkabau community. Minangkabau customs’ philosophical values of adat basandi syarak-syarak basandi kitabullah place women to a noble position. Women are the limpapeh rumah nan gadang, or the pillars of rumah gadang, which symbolize honor and glory. Women, as bundo kanduang, become symbols both physically and personality because they know how to behave in good manners and how to dress appropriately.
Распространение вариантов вируса SARS-COV-2, вызывающих интерес (VOI) и субвариантов Omicron, находящихся под наблюдением (VUM), на основе количества их геномов, депонированных в базу данных GISAID за неделю с 29.04.2023 г. по 05.05.2023 г.
Authors: Чумачкова Елена , Краснов Ярослав , Дмитриева Людмила , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: May 2023

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 вызывающих интерес (VOI) и субвариантов Omicron, находящихся под наблюдением (VUM), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 29 апреля по 5 мая 2023 г.
Coronoid Fracture Reconstruction with Ipsilateral Olecranon Osteoarticular Autograft in the Acute Setting
Authors: Bianco Jake M. , Vopat Matthew L. , Yang Shang-You , Morris Harry A. , Corrigan Chad M. , Hearon Bernard F.
Published: May 2023

Case:

An 18-year-old male polytrauma patient sustained a high-energy posterior fracture dislocation of his left elbow associated with a comminuted and irreparable O'Driscoll type 2 subtype 3 anteromedial facet coronoid fracture. He underwent early coronoid reconstruction using ipsilateral olecranon osteoarticular autograft with incorporation of the sublime tubercle attachment of the medial collateral ligament and repair of the lateral ulnar collateral ligament. A 3-year follow-up revealed a functional, painless, congruent, and stable elbow.

Conclusion:

Early reconstruction of a highly comminuted coronoid fracture may be a useful salvage option for the polytrauma patient, thereby avoiding complications associated with late reconstruction of posttraumatic elbow instability.
Traumatic Obturator Hip Dislocation in a 9-Year-Old Girl
Authors: Wang Daniel D. , Bora Varun G. , Beauvais Dorothy H.
Published: May 2023

Case:

We present a case of traumatic anterior obturator hip dislocation in a pediatric patient with a focus on acute management of this injury. The orthopaedic team successfully performed closed reduction of this injury on an emergent basis, and the patient had minimal issues with ambulation and pain at subsequent follow-up.

Conclusion:

Pediatric traumatic hip dislocations are rare injuries with potentially devastating sequelae, particularly if diagnosis and treatment are delayed. Proper technique during closed reduction is essential. Be prepared for potential emergent open reduction. Two years of postinjury follow-up is recommended to monitor for signs of femoral head osteonecrosis.
The number of Leydig cells in high‑fat diet-fed rats after administration of kepok banana peel extract
Authors: Zulkifli Baidillah , Akmal Muslim , Wahyuni Sri , Gholib Gholib , Adam Mulyadi , Zainuddin Zainuddin , Lubis Triva Murtina , Usrina Nora , Nirmala Fadya
Published: May 2023

The impact of free radicals on testicular Leydig cells can result in the disruption of male reproductive health. The present study aimed to evaluate the effects of a high-fat diet on Leydig cells and the potential of kepok banana peel extract as a medication to mitigate these effects. In total of 20 adult male Wistar rats were assigned to five groups and treated with standard feed (P1), high-fat feed (P2), high-fat feed with simvastatin (P3), and high-fat feed with banana peel extract at doses of 100 and 200 mg/kg BW (P4 and P5). After 60 days of treatment, the number of Leydig cells was determined using HE staining methods. Data were analyzed using an One Way ANOVA test. The results showed that the administration of 100 mg/kg BW of kepok banana peel extract (P4) was able to maintain the number of Leydig cells and counteract the negative effects of a high-fat diet. These findings suggest that kepok banana peel extract may have the potential as a herbal medicine for supporting male reproductive health.
Assessment of gait in mice using simplified analysis tools.
Authors: Fouda Raghda , Argueta Donovan , O'Daniel Kendall , Peterson Kristen , Sorto Tiffany , Gupta Kalpna
Published: May 2023

Gait analysis has received significant attention in many clinical conditions including chemotherapy-induced alterations, degenerative diseases, and hemophilia. Gait changes can be a consequence of physical and/or neural/motor alterations and/or pain. It can provide measurable objective outcomes for following disease progression and the effectiveness of therapy without patient or observer bias. Many devices are available for analyzing gait in clinic. Gait analysis in laboratory mice is frequently used to examine the mechanisms and effectiveness of interventions for movement and pain assessment. However, gait analysis in mice is challenging due to the complexity of image acquisition and analysis of large data sets. We have developed a relatively simple method to analyze gait and validated it using the arthropathy model in hemophilia A mice. We describe artificial intelligence-assisted detection of gait and validation with weight-bearing incapacitance for stance stability in mice. These approaches enable the non-invasive, non-evoked evaluation of pain and the consequent impact of motor function on gait.
Gas Cooled Graphite Moderated and Pressurized Water Reactor the Optimal Choice for Nuclear Power Plants based on a new Group Decision-Making Technique
Authors: khalaf mohammed , sharmi mohammed
Published: May 2023

The aim of this work is to introduce the novel concept of m-polar fuzzy soft set including various types of algorithms and their fundamental operations. We created a mathematical modeling to analyze operational rules and discuss the advantages, disadvantages and natural aspects of algorithms for six types of nuclear power plants. It has been analyzed that emerging trends and the benefits of algorithms are increasing step by step. The suggested modeling with m-polar fuzzy soft set is integrated into the fuzzy mean environment to analyze the effect of the correlation between decision factors on decision results. At the end, a numerical illustration is provided for selecting the best photo to demonstrate the use of generated technique and to exhibit its adequacy.
Corruption in COVID-19 Vaccine Procurement and Distribution: The Case of the COVAX Facility
Authors: Saeed Gul , He Andrea , Kohler Jillian Clare
Published: May 2023

Background The COVID-19 pandemic has presented new opportunities for corruption to infiltrate health and pharmaceutical sectors globally, increasing health inequities within and between countries. COVID-19 vaccine procurement and distribution are specific areas that are vulnerable to corruption due to their attraction of large amounts of public and private funding, involvement of a high number of stakeholders, and lack of centralized oversight. We conducted a descriptive, qualitative study of corruption risks and the use of anti-corruption, transparency, and accountability (ACTA) mechanisms in the international COVID-19 vaccine and distribution process.Results We identified 34 academic articles and policy documents and triangulated documentary data with 16 key informant interviews. A review of the literature identified four distinct corruption risks in the international COVID-19 vaccine procurement and distribution process: (1) a lack of transparency and accountability in the operation of the COVAX Facility; (2) a lack of transparency in the vaccine procurement process; (3) a risk of bribery; and (4) a risk of vaccine theft or the introduction of substandard and falsified vaccines at the point of distribution. Key informants further articulated concerns about a lack of transparency in vaccine pricing and vaccine contracts and the exclusion of civil society organizations from the vaccine deployment process. Reported ACTA mechanisms implemented across various levels of the international vaccine procurement and distribution chain focused primarily on transparency mechanisms, including institutional oversight processes, blockchain-based supply-chain solutions, and civil society engagements.Conclusion Emergency responses to public health crises expose institutions, such as governments and international organizations, to high risks of corruption without adequate ACTA mechanisms. Experiences during the COVID-19 vaccine deployment process demonstrate that efforts to improve transparency will be insufficient without commensurate sanctions programs in place.
Leveraging observational data to identify targeted patient populations for future randomized trials
Authors: Lazzareschi Daniel V. , Fong Nicholas , Pirracchio Romain , Mathis Michael R. , Legrand Matthieu
Published: May 2023

Randomized controlled trials reported in the literature are often affected by poor generalizability, and pragmatic trials have become an increasingly utilized workaround approach to overcome logistical limitations and explore routine interventions demonstrating equipoise in clinical practice. Intravenous albumin, for example, is commonly administered in the perioperative setting despite lacking supportive evidence. Given concerns for cost, safety, and efficacy, randomized trials are needed to explore the clinical equipoise of albumin therapy in this setting, and we therefore present an approach to identifying populations exposed to perioperative albumin to encourage clinical equipoise in patient selection and optimize study design for clinical trials.
Diagnostic value of high-risk HPV E6/E7 mRNA in patients with ASCUS Analysis of pathogenicity of HPV in patients with ASCUS
Authors: Jin xiu , Liu Feifei , Zhang Ya , Ma Yingying , Yang Linqing , Wang Yunfei , Liu Ying
Published: May 2023

Objective: To investigate the infection status of high-risk human papillomavirus (HR-HPV) E6/E7 mRNA in patients with a cytological diagnosis of "atypical squamous cells of undetermined significance" (ASCUS) and to analyze the pathogenic rate of different high-risk HPV subtypes combined with biopsy pathological results to provide a more accurate basis for managing ASCUS patients.
Methods A total of 1387 patients with ASCUS and HPV E6/E7 mRNA positivity who were referred for colposcopy were retrospectively analyzed. They were divided into HPV16+, 18/45+ and other HR-HPV+ groups premenopausal and postmenopausal groups. The pathological results of the biopsy were divided into the LSIL- group (including normal and low-grade squamous intraepithelial lesions) and the HSIL+ group (including high-grade squamous intraepithelial lesions and higher lesions). SPSS was used for the analysis.
Results The age group 31-40 years had the highest level of HPV16+, and HPV18/45+ was the highest in the 41-50 years group. The detection rates of HSIL+ in the HPV16+, HPV18/45+, HPV 16/18/45+ and Other HR-HPV+ groups were 48.4%, 18.8%, 43.9% and 15.0%, respectively. The infection rates of HPV16/18/45 in postmenopausal and premenopausal women were 42.4% and 34.3%, respectively. In the HPV18/45 group, the incidence of HSIL+ was 30.0% in postmenopausal women and 15.0% in premenopausal women (P < 0.01). In the HPV 16+ and Other HR-HPV+ groups, the incidence of HSIL+ in postmenopausal patients was not significantly different from that in premenopausal patients. The incidence of cervical cancer in postmenopausal patients is significantly higher than that in premenopausal patients.
Conclusions Colposcopy referral or further biopsy is recommended for all ASCUS patients with HPV16/18/45E6/E7 mRNA positivity and postmenopausal patients with HR-HPVE6/E7 mRNA positivity. For premenopausal ASCUS patients with other HR-HPV E6/E7 mRNA positivity, colposcopy should be performed if possible, depending on the specific situation, to achieve early detection and diagnosis.
Effects of the 1RS.1BL wheat-rye translocation on kernel and bran content of bread wheat
(Triticum aestivum L.)
Authors: Aydın Nevzat , Demir Bedrettin , Sayaslan Abdulvahit , KÖSE Özge Doğanay ERBAŞ , Güleç Tuğba , Şermet Cemal , Savaşlı Erdinç , Sönmez Mesut Ersin , Koyuncu Mehmet , MUT Zeki
Published: May 2023

Rye introgressions are important contributors to the genetic diversity of wheat. In this study, we investigated the effects of a wheat-rye translocation 1RS.1BL in bread wheat on kernel and bran properties and mineral content. The plant material consisted of 147 recombinant inbred lines (RILs) and five control cultivars, including the parent. The genotypes were grown in Turkey at two different locations for two consecutive years.The protein, starch, fat, ash, dry matter, acid detergent insoluble fiber (ADF), neutral detergent insoluble fiber (NDF), potassium (K), phosphorus (P) and magnesium (Mg) contents of kernels and bran of the RILs were determined. Statistically significant differences were found between the genotypes in terms of all the examined characteristics except the amount of dry matter. The RILs carrying translocation 1RS.1BL had a higher average ADF, NDF, protein content, ash content, K, Mg, and P contents of kernels, as well as a higher average ADF, NDF, ash, and K bran contents than the RILs without the translocation. The bran of the RILs without the translocation had higher values in terms of fat, starch, and phosphorus content. The results indicate that wheat- rye translocation 1RS.1BL has a significant effect on both whole wheat kernel and bran content, and can be used to enrich the content of wheat bran.
Launching of several small- scale successive jets from calcium bright knots and formation of chromospheric anemone jets on the Sun
Authors: Singh Kunwar Alkendra Pratap , Nishida Keisuke , Shibata Kazunari
Published: May 2023

Recent space solar observations revealed that solar atmosphere such as corona and chromosphere is full of small- scale jets1, associated with small- scale explosions called nanoflares. There is increasing indirect evidence that these jets may be produced by the physical mechanism similar to that of large scale flares, i.e., release of magnetic energy stored in the solar atmosphere through magnetic reconnection2-4, and also that these jets and nanoflares may be related to the heating of corona and chromosphere as well as acceleration of solar wind5,6. Among small scale jets, the so called chromospheric anemone jets in the active region on the Sun remains puzzling, because they are one of the smallest scale jets so that their footpoints (bright knots) have not been well resolved7,8,9. We propose a new model for chromospheric jets using the three-dimensional magnetohydrodynamic (MHD) simulations, which show that the continuous, upward rising of small-scale twisted magnetic flux rope in a magnetized solar chromosphere play an important role in small-scale magnetic reconnections and launching of several small-scale jets during the evolution of the chromospheric anemone jets. Our new, self-consistent, three-dimensional computer modeling of small-scale, but ever-changing flux rope emergence in the magnetized solar atmosphere is found to be fairly consistent with observations.
Encoding Beacon Statements for Code Comment Generation
Authors: Jia Nan , Chen Jie , Li Mingliang
Published: May 2023

High-quality code comment is important to help developer review and comprehend source code. Inspired by the effectiveness of deep learning techniques in the NLP field, many studies focus on using the machine translation algorithm to automatically generate comment for the source code. Most of the current studies typically involve in collecting a large number of dataset regarding the function-comment pairs, and then encode the information (e.g., AST) from the whole function for training a generation model. Most of current studies indistinguishably encode every statement in a function, which may not be the best strategy for comment generation because each statement in a function plays different roles, and the non-core code statements may have no effect or even a negative effect on the comment generation. In this paper, we propose a flexible encoding strategy that highlights the most informative statements from the function, called beacon statements, for code comment generation. Specifically, the beacon statements are detected from the function according to their roles when human understanding program, and then a pre-training model is proposed to encode the knowledge of the beacon statements. At last, the knowledge of the beacon statements is transferring to a basic model for comment generation by sharing the training parameters. The encouraging experimental results demonstrate the feasibility and effectiveness of our comment generation model.
Application of 3D printing for bioreactor prototype development
Authors: Santos Robson Marino Garcia , Rodrigues Leonardo Ribeiro
Published: May 2023

Growing a patient's bone cells in custom-made porous support structures (scaffolds) has been considered as a future alternative to reduce the risks associated with bone transplants and simplify this procedure. To make it viable, 3D printing has been studied for bioreactor production, a fundamental equipment for the development of this technique, but expensive and difficult to manufacture. So, after a detailed literature review, this article compiles requirements for the design of new bioreactors and parameters for its validation, applying them in the development of a prototype to be manufactured through 3D printing. The project was developed and evaluated through simulations performed with Solidworks software, considering the shear stress generated in an 8 mm3 reference scaffold model with 400 µm cubic pores. The proposed designs are different from others identified in the literature review and presented average results within the range defined as adequate, from 0.11 to 30 mPa. No similar study, compiling information and presenting parameters with the same level of detail, was identified. Future studies should focus on design adjustments to improve flow perfusion homogeneity and on laboratory tests.
Two-dimensional inerter-enhanced nonlinear energy sink
Authors: Yang Tianzhi , Dang Wenhu , Chen Liqun
Published: May 2023

Multiple-direction vibration widely exists in the environment, which is harmful to instruments and people. Hence, the high demand for vibration isolators with exceptional efficiency is thus evident. Although the proposed nonlinear energy sink was proven to be highly utility, most of the developed such devices, even with some inerter enhanced NESs, are limited to one-dimensional vibration suppression. In this paper, we propose a two-dimensional inerter-enhanced NES (2D IE-NES) which is applicable for multiple-directional low-frequency vibration suppression. The Lagrangian method is employed to derive the dynamic equations of the 2D IE-NES. Then these differential equations are solved by means of the Runge-Kutta method. Numerical results show that the novel 2D IE-NES configuration can isolate vibration more efficiently than the traditional NES under both instantaneous shock and constant periodic excitation. The role of the inerter in the vibration decaying process is highlighted in energy flow. This paper provides a new platform for the low-frequency multiple-direction vibration isolator.
Fundamentals and implication of PZC determination for activated carbons in aqueous electrolytes
Authors: Fic Krzysztof , Sr Sylwia , Galek Przemyslaw , Menzel Jakub , Platek-Mielczarek Anetta
Published: May 2023

The point of zero charge (PZC) is crucial for investigating molecular level charging mechanisms in energy storage systems, as demonstrated in electrochemical capacitors. Three electrochemical techniques were studied: cyclic voltammetry (CV), staircase potentio electrochemical impedance spectroscopy (SPEIS) and step potential electrochemical spectroscopy (SPECS) for two activated carbons (ACs) with 0.1 mol L− 1 aqueous solutions of LiNO3, Li2SO4, and KI. The porous AC charging process in aqueous electrolytes is a complex phenomenon; the ion mixing zone covered a wide potential region. Inadequate PZC determination could lead to obscure data evaluation, which could further provide a misguided mechanism description at the molecular level. In the aqueous solutions studied, the adsorption of specific ions and active participation of all ionic species in the electrical double-layer formation were considered. The SPECS technique was determined to be the most beneficial for the PZC determination in electrochemical quartz crystal microbalance applications.
Chromatographic purification of small extracellular vesicles using an affinity column for phospholipid membranes
Authors: Masaki Kanako , Ahmed Abo Bakr F. , Ishida Takenori , Funabashi Hisakage , Hirota Ryuichi , Ikeda Takeshi , Kuroda Akio
Published: May 2023

Purpose: The use of small extracellular vesicles (sEVs) such as exosomes for therapeutic purposes has recently generated great interest. Developing an efficient, rapid, scalable, and reproducible sEV purification method is necessary. Therefore, this study aimed to investigate whether chromatography using an ExoPUA column, an affinity column for phospholipid membranes, could potentially meet this demand.
Methods: We used the ExoPUA column connected to a fast-performance liquid chromatography system.
Results: One-step chromatographic purification of sEVs from a culture supernatant using the ExoPUA protocol resulted in an 82-fold increase in purity with a yield of 38% of sEVs on average. Transmission electron microscopy and western blotting analysis indicated that purified sEVs were intact.
Conclusion: The purification performance of the ExoPUA protocol yields superior results compared with that of the differential ultracentrifugation method, which is the most commonly used purification method for sEVs in the laboratory. Furthermore, sEVs were purified in the bind-elute mode and the ExoPUA column can be refreshed and sterilized with sodium hydroxide (NaOH), having more potential for multiple sEV purification in a scalable and industrial manner.
IOT Based Automatic Intravenous Bag Data Logging Monitoring and Alert System
Authors: SRI S , RAJESHKUMAR G , SARANYA E , SARANYA K , KAVITHA R
Published: May 2023

Saline, one of the most widely used intravenous (IV) medications, is essential in the treatment of critically ill patients. Monitoring the level in the saline bottle is crucial because blood flows when the bottle is empty and the needle is still near the vein into the bottle from the outside. In hospitals, it is the responsibility of nurses or caregivers to monitor level of saline bottle. The proper timing of withdrawing the needle from the patient's vein is usually ignored due to carelessness and any unusual circumstances that result in great casualties and should also lead to death. In addition, health services can be offered through remote monitoring. To avoid the accident caused by caregiver ignorance and offer remote, we designed a cost-effective intelligent saline level for supervision in health services. a monitoring system that combines sensor and Internet of Things (IOT) technology. This system was created using load cell and a cheap, very low power microcontroller. The load of the bottle is converted to the selected voltage by the load sensor. The ESP8266 microcontroller generates and publishes a specific message based on voltage received from the sensor. Publish and display messages on subscriber devices like health professionals, nurses or caregivers. The proposed monitoring system delivers message to subscribers in a reliable manner, which is crucial for the healthcare industry. With the help of a human, the valve of the saline bottle closes automatically
Highly conductive and stretchable hydrogel using a percolated network of whiskered gold nanosheets
Authors: Hyeon Taeghwan , Lim Chaehong , Lee Seunghwan , Park Chansul , Kim Jeong Hyun , Kim Dae-Hyeong
Published: May 2023

Conductive and stretchable hydrogels (CSHs) are promising materials for soft bioelectronics. However, hitherto developed CSHs suffer from unsatisfactory electrical conductivity and stretchability. As the electrical properties of a CSH are determined by the type of conductive components and the quality of their percolation, a breakthrough in these factors is required for the high performance CSH. Here, we developed CSHs including a percolated network of whiskered gold nanosheets (wAu-CSHs). A high fraction of whiskered gold nanosheets (> 3 vol.%) is impregnated in the hydrogel matrix through a sequential formation process of the gold nanomaterial network and the hydrogel matrix. This wAu-CSH fabrication method is applicable to various hydrogels includingpolyacrylamide, polyacrylic acid, and polyvinyl alcohol, and even to an organogel such as polybutyl acrylate. Regardless of the types of hydrogels, the wAu-CSH exhibits a conductivity of ~ 500 S/cm and a maximum strain of ~ 300 % evenwithout any supporting substrate. We increased the density of the gold nanomaterial network through a pressing process to maximize the conductivity of wAu-CSHs,exhibitinga high conductivity of ~ 3300 S/cm and a maximum strain of ~ 100% with a supporting hydrogel layer.
Mother Optimization Algorithm: A New Human-Based Metaheuristic Approach for Solving Engineering Optimization
Authors: Matoušová Ivana , Trojovský Pavel , Dehghani Mohammad , Trojovská Eva , Kostra Juraj
Published: May 2023

This paper presents a new metaheuristic method called Mother Optimization Algorithm (MOA) that mimics the human interaction between a mother and her children. The fundamental inspiration of MOA is to simulate the mother's care of children in three phases education, advice, and upbringing. The mathematical model of MOA used in the search process and exploration is presented. The performance of MOA is assessed on a set of 52 benchmark functions, including unimodal and high-dimensional multimodal functions, fixed-dimensional multimodal functions, and the CEC 2017 test suite. The results indicate that MOA's proposed approach, which balances exploration and exploitation, effectively supports the search process and can generate appropriate solutions for optimization problems. The outcomes quality obtained from MOA has been compared with the performance of twelve often-used metaheuristic algorithms. Upon analysis and comparison of the simulation results, it was found that the proposed MOA outperforms competing algorithms with superior and significantly more competitive performance. Specifically, the proposed MOA delivers better results in most objective functions. Furthermore, the application of MOA on four engineering design problems demonstrates the efficacy of the proposed approach in solving real-world optimization problems.