bluuebunny/crossref_metadata_2025 huggingface dataset:
MODEL OF DIGITAL TOOLS IMPLEMENTATION IN THE MANAGEMENT OF OPERATIONAL LOGISTICS ACTIVITIES IN THE CONDITIONS OF FORMATION OF TECHNOLOGICAL INDEPENDENCE
Authors:   St. Petersburg Polytechnic University, Saint-Petersburg, Russia, Melekhin Vyacheslav D.
Published: February 2024

The article examines the issue of introducing digital tools into the management of operational logistics activities of enterprises. The author proposes a new model that allows the implementation of digital tools in an organization from the point of view of practice. The model developed on the basis of research and analysis of existing approaches will allow the successful implementation of digital tools in operational logistics activities. The key conclusion of the article is that using the model will allow enterprises and organizations to make informed decisions about the implementation of digital tools. This can improve the efficiency and competitiveness of enterprises, optimize logistics operations. The article can be used by enterprises and organizations that are interested in the effective implementation of digital tools in their logistics activities.
INFLUENCE OF MARKETING ON THE EFFICIENCY OF BAKERY FACTORY ACTIVITY
Authors:   Kazan State Energy University, Kazan, Russia, Gnezditsky Mikhail A. , Zaripova Rimma S. ,   Kazan State Energy University, Kazan, Russia
Published: February 2024

This article considers the study of the influence of marketing on the performance of a bakery. The purpose of the study is to identify the relationship between marketing strategies and bakery performance. In light of increasing competition and changing consumer preferences, bakeries need to actively attract new customers and retain existing audiences. As a result of the study, practical recommendations for optimising the marketing activities of a bakery to improve its performance have been proposed. In practice, the results of the study can be used to develop and implement marketing strategies of the bakery, aimed at increasing production and sales, expanding the range of products, attracting new customers, strengthening the image of the enterprise. In addition, the received recommendations can help to reduce the risks of inefficient use of resources for marketing activities and increase the overall efficiency of the bakery.
IMPACT OF THE IT REVOLUTION ON THE LABOR MARKET: PROSPECTS FOR GROWTH OF DEMAND FOR IT SPECIALISTS AND CHALLENGES FOR TRADITIONAL PROFESSIONS
Authors:   Grozny State Oil Technical University named after Academician M. D. Millionshchikov, Grozny, Russian Federation, Tasueva Khava Z.-A. , Natalson Alexander V. ,   Kazan State Energy University, Kazan, Russian Federation, Garipova Gulnara R. ,   Kazan National Research Technological University, Kazan, Russian Federation
Published: February 2024

This article examines the impact of the information technology revolution on the labor market. Particular attention is paid to the prospects for growing demand for IT specialists and the challenges faced by traditional professions in a rapidly changing technological environment. Trends in the development of the labor market, factors contributing to the growth in demand for IT personnel are analyzed, and possible adaptation strategies for traditional professions are proposed.
FINANCING EVENT ACTIVITIES AT THE REGIONAL LEVEL: FORMS AND MECHANISMS OF SUPPORT
Authors:   St. Petersburg State University of Economics, St. Petersburg, Russia, Koroleva Daria A.
Published: February 2024

The author examines the state of the event market in Russia in the post-pandemic period; describes the groups of sources of funding for event events that exist in the country; systematizes forms of support for event activities from the state; provides a systematic list of public and private projects to finance event activities in the socio-cultural sphere. In the article, the author proposes and describes a new model of interaction between executive authorities and business in the field of supporting event events at the regional level.
THE STRATEGY OF INCREASING COMPETITIVENESS IN THE CONTEXT OF SUSTAINABLE DEVELOPMENT
Authors:   Federal State Budgetary Educational Institution of Higher Education «Donetsk Academy of Management and Public Administration» FSBEI HE «DONAMPA», Donetsk, Donetsk People’s Republic, Russia, Meshkova Victoria S.
Published: February 2024

Practice shows that in modern conditions of economic development, the lack of clear strategies, economic goals and criteria for organizational development makes solving the issue of increasing competitiveness very difficult and problematic for many organizations. Currently, in order to take a leading position, organizations must timely update their technologies, including digital ones, conduct marketing research, and establish feedback with consumers.
Denk- und Entwicklungspsychologe, Didaktiker und Lehrerbildner
Authors: Reusser Kurt , Baer Matthias
Published: February 2024

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Der Wandel des Seminars zur Maturitätsschule
Authors: Merazzi Claude , Wyss Heinz
Published: February 2024

Am 14.8.1990 hat der Grosse Rat des Kantons Bern in seltener Einmütigkeit den Grundsätzen der Gesamtkonzeption der Lehrerbildung (GKL) zugestimmt. Die berufliche Grundausbildung wird ins Erwachsenenalter verlegt. Sie setzt eine mit der Maturität oder einem gleichwertigen Diplom ausgewiesene Allgemeinbildung und eine mindestens halbjährige ausserschulische Tätigkeit voraus. Zugleich öffnet sich der Zugang zur Lehrerbildung für Absolventen beruflicher Bildungswege, sofern sie durch den Besuch der Berufsmittelschule und/oder durch eine berufsbegleitende Fortbildung die nötigen Kenntnisse erworben haben, auf die sich die Lehrerbildung in ihrem Sachbezug abstützt. Mit der Verwirklichung dieser einstimmig verabschiedeten Vorlage koppelt sich die Allgemeinbildung von der Berufsausbildung der Lehrer und Lehrerinnen aller Schulstufen und Schultypen ab. Damit wandeln sich die Seminare. Im Prozess ihrer Umgestaltung und inneren Aufgliederung geht es darum, die an ihnen entwickelte und gepflegte Lehr- und Lernkultur zu erhalten. Als gegenwartsnahe Schulen, die sich lebensbezogenen Lernzielen und -inhalten verpflichtet wissen, wollen sie innerhalb der Sekundarstufe II ihr eigenes Profil wahren. In ihrem Teilbereich als allgemeinbildende Mittelschulen werden die Seminare zu einem neuen Typ der Maturitätsschulen, gekennzeichnet durch den Einbezug der Human- und Sozialwissenschaften und durch die besondere Gewichtung der Kommunikations- und Medienpädagogik, der Kunsterziehung, der Musik und der Bewegungsschulung. Die Nachzeichnung der inneren Ausgestaltung des Gymnasiums zeigt, dass die Schule in ihrer Entwicklung dem gesellschaftlichen Wandel folgt. In der Regel mit dem üblichen Rückstand. Anders die Seminare. Dadurch, dass sie ihren Bildungsauftrag stets als Aufgabe der verhaltenswirksamen Persönlichkeitsbildung verstanden haben und weniger auf blosse Wissensakkumulation bedacht waren, kommen sie den gesellschaftlichen Bedürfnissen und Bildungsanliegen unserer Zeit in besonderem Masse entgegen. Als Schulen, die sich inskünftig nicht mehr mit der Lehrerbildung verflechten, sondern die offen sind für ein weites Spektrum an Ausbildungsgängen, führen die Seminare in ihrem Teilbereich als Maturitätsschulen zur Hochschulreife. Sie befähigen zum Studium durch ein geschultes Urteilsvermögen, durch die Fähigkeit zur Informationsbeschaffung und -verarbeitung und durch eine Denk- und Handlungsfähigkeit, die sich in der Auseinandersetzung mit gesellschaftlich relevanten Inhalten entwickelt hat. Der vorliegende Text stützt sich auf Ausschnitte aus der Festschrift "Ecole Normale de Bienne 1964-1989. 25e anniversaire" (Biel 1990) von Claude Merazzi, Er fasst in freier Uebertragung und Nachzeichnung die wesentlichen Aspekte künftiger Seminarentwicklung zusammen und gibt damit zugleich wieder, zu welchen Einsichten das der Realisierung der GKL vorgreifende Gespräch in der Kantonalen Seminardirektorenkonferenz geführt hat.
Berufsleute werden Primarlehrerinnen und Primarlehrer
Authors: Beck Erwin , Krucker Thomas
Published: February 2024

Von Januar 1992 an können sich im Kanton St. Gallen Berufsleute mit geeigneten Voraussetzungen in einer fünfsemestrigen Ausbildung zu Primarlehrerinnen und Primarlehrern ausbilden lassen. Der Erziehungsrat des Kantons St. Gallen hat an seiner Sitzung vom 21. November 1990 beschlossen, am Lehrerseminar Rorschach einen Kurs zur Umschulung von Berufsleuten zu Primarlehrern und Primarlehrerinnen durchzuführen. Dieser Kurs soll jenen den Weg zum Primarlehrerberuf öffnen, welche weder die seminaristische Ausbildung noch eine andere Mittelschule absolviert haben. Viele Berufsleute bringen wesentliche Erfahrungen für den Lehrberuf mit. Im Vollzeitkurs wird die Allgemeinbildung ergänzt und vertieft, und die methodisch-didaktischen Fähigkeiten werden im direkten Praxisbezug erworben.
Welche Chancen liegen im Lehrberuf als Zweitberuf?
Authors: Hirsch Gertrude
Published: February 2024

Der Beitrag berichtet über Erfahrungen von 15 Lehrkräften im Zweitberuf. Ihre Erfahrungen regen zum Nachdenken über Chancen, die der Lehrerberuf als Zweitberuf bieten könnte, an. Drei Anregungen werden zur Diskussion gestellt: Fördert ihre persönliche Reife beim Berufseintritt den pädagogischen Umgang mit der Generationendifferenz? Sind Berufswechsler dem Lehrerimage förderlich? Tragen sie zur Entwicklung von Teamgeist im Kollegium und zur Oeffnung der Schule bei?
Anmerkungen zur organisatorischen und didaktisch-methodischen Gestaltung der Lehrerausbildung als Zweitausbildung für Berufsleute
Authors: Steiner Susanne
Published: February 2024

Die Autorin, selbst Absolventin eines zweiten Bildungsweges - sie besuchte nach dreijähriger Damenschneiderinnenlehre das Handarbeitslehrerinnenseminar - ist heute Inspektorin für Handarbeiten/werken im Kanton Bern und Mitglied der EDK-Studiengruppe "Zugänge zum Lehrerberuf für Berufsleute". In einer Diplomarbeit, die sie 1988 im Rahmen ihrer Ausbildung zur Seminarlehrerin der Typengruppe Handarbeit verfasste, stellt sie zusätzliche Ueberlegungen an zur Gestaltung der "Lehrerausbildung als Zweitausbildung für Berufsleute" (Titel der Diplomarbeit; siehe die bibliographischen Angaben in der Rubrik 'Bildungsforschung' dieses Heftes). Wir geben hier in leicht gekürzter Form Ausschnitte aus dem Kapitel wieder, das die Auswirkungen des "Reformkonzepts der Arbeitslehrerinnenausbildung 86 für den deutschsprachigen Teil des Kantons Bern" auf ein Ausbildungsmodell des zweiten Bildungswegs behandelt. (Die Zitate beziehen sich auf das erwähnte Konzeptpapier.)
Anmerkungen zur Ausbildung von Berufsleuten zu Berufsschullehrern und -lehrerinnen. Zwischen Anregung und Einschränkung
Authors: Kuster Hans
Published: February 2024

Für jene Personen, die an einer gewerblich-industriellen Berufsschule die berufskundlichen Fächer unterrichten, ist das Lehren Zweitberuf: Sie vermitteln Kenntnisse, die zu ihrem Grundberuf gehören. Als Lehrer um Schweizerischen Institut für Berufspädagogik (SIBP) habe ich es ausschliesslich mit Männern und Frauen - Ingenieuren, Schreinermeistern, Küchenchefs, Drogistinnen, Damenschneiderinnen, Floristinnen - zu tun, die im Alter von durchschnittlich fünfunddreissig Jahren eine Ausbildung antreten, die sie für den Lehrberuf qualifiziert. Alle diese Personen beabsichtigen, in Zukunft hauptamtlich lehrend tätig zu sein. Sie wollen den zukünftigen Berufsleuten in der Grundausbildung (also der "Lehre") oder in der Weiterbildung (z.B. in Meisterkursen) die Grundlagen des entsprechenden Berufes weitergeben. In der Folge will ich einige Punkte aufgreifen, die mir als Lehrerbildner wichtig sind.
EMPLOYMENT OF THE POPULATION IN THE SUSTAINABLE DEVELOPMENT OF TOURISM
Authors: Konul Valiyeva Konul Valiyeva
Published: February 2024

Developing the tourism sector and increasing employment in this field will lead to an increase in the specific weight of the non-oil sector in the country's Gross Domestic Product (GDP). Also, foreign currencies brought to the country by foreign tourists within the framework of international tourism cause the strengthening of the national currency of Azerbaijan, the manat. This is one of the factors that will help to achieve stability against internal and external influences, which is reflected in the national priorities that cover the social and economic development issues of Azerbaijan until 2030. It is noted that the main condition for the stability of the country's economy is its diversification.
Currently, it is a very important priority to make tourism one of the leading areas in the non-oil sector in our country. After achieving this, the main issue is to regulate the sustainable development of tourism. In this aspect, the formation of the tourism product and setting the right price for it will ensure development. Because when the product is released to the market, its price should match its quality. If the quality of the tourism product in our country increases, it is predicted that there will be changes in the dynamics of prices.
Keyword: tourism, sustainable development, economy, non-oil sector
FORMATION OF THE NON-OIL SECTOR OF AZERBAIJAN THROUGH THE SUSTAINABLE DEVELOPMENT OF THE MARKET ECONOMY
Authors: Gazanfar Suleymanov Gazanfar Suleymanov , Natavan Ibragimova Natavan Ibragimova
Published: February 2024

The article reveals the essence of the modern market economy. The state not only complements and corrects the action of the market in a socially oriented economy, but is also the most important mechanism that ensures the social orientation of the development of a market economy.
It also reflects the essence of long-term concepts that form the basis for stable and sustainable development of the non-oil sector, which has taken a course towards expanding and diversifying work in this direction.
The article indicates the reforms adopted and implemented since the formation of Azerbaijan as an independent state, related to its multifaceted capabilities, accompanying the comprehensive growth of the economy, both at the micro and macro levels.
Keywords: non-oil sector, market economy, development, economic relations, economic transformations.
KİMYA SƏNAYESİNDƏ ƏSAS KAPİTALA YÖNƏLDİLƏN İNVESTİSİYALARIN MƏHSULUN RƏQABƏT QABİLİYYƏTİNƏ TƏSİRİ
Authors: Elmir Mehdiyev Elmir Mehdiyev
Published: February 2024

Məqalədə Azərbaycan Respublikasında kimya sənayesində istehsal edilmiş ümumi məhsul buraxılışının dinamikası, ixrac strukturu statistik mənbələr əsasında təhlil edilərək qiymətləndirilmişdir. Burada kimya sənayesi məhsullarının rəqabət qabiliyyətinin artırılmasında istehsalın texniki cəhətdən innovativ texnologiyalara əsaslanan avadanlıqlarla yenidən təchiz edilməsinin əhəmiyyəti izah edilmişdir. Məqalədə həmçinin kimya sənayesi üzrə əsas kapitala yönəldilən investisiyalarla ümumi məhsul buraxılışı və ixrac arasındakı asılılıq korrelyasiya-reqressiya analizi əsasında qiymətləndirilmişdir.
Açar sözlər: kimya sənayesi, korrelyasiya, reqresiya, investisiya, əsas kapital.
The Ability of Brand Trust as a Mediator on the Determinants of Customer Loyalty: Study on Mie Sagu Waraka (SAWA) in Ambon, Indonesia
Authors: Tabelessy Walter
Published: February 2024

The aim of this research is to investigate the determinants of customer loyalty for Mie Sagu Waraka (SAWA) in Ambon, which is analyzed using the factors of brand image, brand trust, product differentiation, and purchasing decisions, as well as testing the ability of brand trust as a mediating variable. This research is explanatory research using a questionnaire to obtain data from respondents, as many as 171 Mie Sagu Waraka (SAWA) customers obtained using a purposive sampling technique. PLS-SEM as a data analysis technique was used to test the hypothesis proposed in this research and analyzed using the help of the SmartPLS version-4 application. The results of data processing found that brand image does not have a significant influence on customer loyalty, brand trust has a significant influence on customer loyalty, image brand has a significant influence on brand trust, product differentiation has a significant influence on customer loyalty, purchasing decisions have a significant influence on customer loyalty, and product differentiation has a significant influence on purchasing decisions, and brand trust is able to significantly mediate the relationship between brand image and customer loyalty.
Effect of Different Plasma/Red Blood Cell Ratios in Blood Transfusion Therapy on Hepatorenal Function and Nutritional Status of Patients with Traumatic Hemorrhage
Authors: Wei Song , Hui Wang , Dongxing Wang , Ying Gao
Published: February 2024

Traumatic hemorrhage is the major cause of death in trauma patients, and blood transfusion therapy is a necessary measure to ensure their life safety and nutritional status. However, a significant controversy exists in clinical practice regarding the optimal ratio of plasma to red blood cells for transfusion therapy. In this study, we compared the differences in hepatorenal function and nutritional status of three groups of patients with traumatic hemorrhage receiving blood transfusions with different plasma/red blood cell ratios (2.5:1, 1:1, and 1:1.5). Patients with plasma/red blood cell ratios of 1:1 exhibited the best post-transfusion blood status, the best hepatorenal function and nutritional status after blood transfusion, and the lowest nutritional risk level. In conclusion, transfusion therapy for traumatic patients with a 1:1 plasma/red blood cell ratio can effectively improve the coagulation function of patients and replenish blood volume, while maintaining the stability of hepatorenal function and nutritional status.
ОСОБЛИВОСТІ КЛІНІКИ, ДІАГНОСТИКИ ОНІХОМІКОЗІВ СТОП ТА ПРИНЦИПИ КОМПЛЕКСНОЇ ТЕРАПІЇ
Authors: Aiziatulov Rushan
Published: February 2024

Мета роботи. На підставі аналізу джерел літератури, власних спостережень вивчити клінічні особливості оніхомікозів стоп і розробити тактику комплексного лікування.

Матеріали і методи. Під спостереженням були хворі на оніхомікоз стоп. Проводилися лабораторні дослідження: загальний аналіз крові; аналіз сечі; дослідження функції печінки; мікроскопічне дослідження патологічного матеріалу на гриби зі зрізів уражених нігтів.

Результати і обговорення. Згідно нашим клінічним спостереженням сприятливі терапевтичні результати досягалися при використанні системних антимікотичних препаратів ітраконазол та тербінафін, а найбільш безпечним  застосуванням була пульс-терапії. Ітраконазол призначався внутряшньо після їжі по 2 капсули по 100 мг 2 рази на день (400 мг на добу) протягом 7 днів, потім перерва 3 тижні і курс повторювався (всього 3-4 курси залежно від форми оніхомікозу, площі ураження). Тербінафін призначався внутрішньо в дозі 500 мг на добу (1 тиждень) з наступною 3-тижневою перервою (такий курс повторювали двічі). Клінічну та мікологічну ефективність препаратів ітраконазол та тербінафін оцінювали через 12 місяців, внаслідок чого було підтверджено терапевтичний ефект при хорошій переносимості.

Висновки. Лікування оніхомікозів стоп необхідно проводити в дерматовенерологічних закладах, де мають бути необхідні кадрові ресурси, здатні покращити якість життя пацієнтів, що є першочерговим завданням лікування будь-якого хронічного захворювання.
Aliran Al-Jabariyah dan Al-Qadariyah
Authors: Islamuddin Amri , Amri Muhammad , Santalia Indo
Published: February 2024

Artikel ini bertujuan untuk menganalisis latar belakang dan pemikiran aliran Al-Jabariyah dan Al-Qadariyah dengan menggunakan metode analisis deskriptif terhadap sejumlah literatur pustaka (library approach). Dari hasil penelitian ini, terdapat dua aliran yang telah mewarnai sejarah pemikiran Islam yang berkaitan dengan kehendak manusia, yaitu aliran al-Jabariyah yang identik dengan prinsip predestination memandang bahwa manusia tidak memiliki kuasa dan kehendak untuk berbuat sesuatu, seluruh perbuatannya telah diatur dan ditetapkan oleh Tuhan. Demikian juga terdapat aliran al-Qadariyah yang memiliki prinsip free will atau free act yang menyatakan bahwa setiap manusia memiliki kebebasan dan bertindak atas dirinya sendiri, artinya segala perbuatannya tidak ditetapkan oleh Tuhan, melainkan semuanya tergantung pada kehendak manusia.
Kata kunci: Aliran, Al-Jabariyah, Al-Qadariyah
Pendidikan Tasawuf dalam Kitab Al-Hikam Karya Syekh Ibnu Atha’illah As-Sakandari
Authors: Qudsiyyah Fitroh , Hanipudin Sarno , Sajidin Sajidin
Published: February 2024

Penelitian tentang pendidikan tasawuf ini mengambil referensi utama yaitu kitab Al-Hikam karya Syekh Ibnu Atho’illah As-Sakandari. Penelitian ini merupakan library research yaitu meneliti dokumen berupa buku, koran, artikel, atau jurnal-jurnal lainnya untuk mengetahui kandungan yang bisa didapat dalam kitab tersebut. Tujuan penelitian ini adalah untuk mengetahui bagaimana konsep pendidikan tasawuf dalam kitab Al-Hikam. Hasil penelitian menunjukan informasi bahwa pendidikan merupakan usaha membimbing dan membina serta bertanggung jawab untuk mengembangkan intelektual pribadi anak didik ke arah kedewasaan dan dapat menerapkannya dalam kehidupan sehari-hari. Sedangkan konsep pendidikan tasawuf dalam kitab Al-Hikam adalah usaha membersihkan diri dari sifat tercela dan menghiasinya dengan sifat terpuji, berjuang memerangi hawa nafsu sehingga jiwa tersebut bisa sampai kepada Allah SWT.

Kata kunci: Pendidikan Tasawuf, Kitab Al-Hikam, Ibnu ‘Athaillah
Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus
Authors: Wu Hong-Xiao , Ding Xiao-Yan , Xu Ya-Wen , Yu Ming-Hua , Li Xiao-Mi , Deng Na , Chen Jing-Long
Published: February 2024

BACKGROUND

Hepatocellular carcinoma (HCC) patients complicated with portal vein tumor thrombus (PVTT) exhibit poor prognoses and treatment responses.

AIM

To investigate efficacies and safety of the combination of PD-1 inhibitor, transcatheter arterial chemoembolization (TACE) and Lenvatinib in HCC subjects comorbid with PVTT.

METHODS

From January 2019 to December 2020, HCC patients with PVTT types I-IV were retrospectively enrolled at Beijing Ditan Hospital. They were distributed to either the PTL or TACE/Lenvatinib (TL) group. The median progression-free survival (mPFS) was set as the primary endpoint, while parameters like median overall survival, objective response rate, disease control rate (DCR), and toxicity level served as secondary endpoints.

RESULTS

Forty-one eligible patients were finally recruited for this study and divided into the PTL (n = 18) and TL (n = 23) groups. For a median follow-up of 21.8 months, the DCRs were 88.9% and 60.9% in the PTL and TL groups (P = 0.046), res-pectively. Moreover, mPFS indicated significant improvement (HR = 0.25; P < 0.001) in PTL-treated patients (5.4 months) compared to TL-treated (2.7 months) patients. There were no treatment-related deaths or differences in adverse events in either group.

CONCLUSION

A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types I-IV.
Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in Helicobacter pylori-infected patients
Authors: Wang Li-Hui , Su Bin-Bin , Wang Sheng-Shu , Sun Guan-Chao , Lv Kun-Ming , Li Yi , Shi Hui , Chen Qian-Qian
Published: February 2024

BACKGROUND

Reflux esophagitis has an increasing prevalence and complex and diverse symptoms. Identifying its risk factors is crucial to understanding the etiology, prevention, and management of the disease. The occurrence of reflux esophagitis may be associated with food reactions, Helicobacter pylori (H. pylori ) infection, and metabolic syndromes.

AIM

To investigate the risk factors for reflux esophagitis and analyze the effects of immunoglobulin (Ig) G-mediated food intolerance, H. pylori infection, and metabolic syndrome on reflux esophagitis.

METHODS

Outpatients attending the Second Medical Center of the PLA General Hospital between 2017 and 2021 were retrospectively enrolled. The patients’ basic information, test results, gastroscopy results, H. pylori test results, and IgG-mediated food intolerance results were collected. Multivariate logistic regression analysis was used to analyze risk factors for reflux esophagitis. Statistical mediation analysis was used to evaluate the effects of IgG-mediated food intolerance and metabolic syndrome on H. pylori infection affecting reflux esophagitis.

RESULTS

A total of 7954 outpatients were included; the prevalence of reflux esophagitis, IgG-mediated food intolerance, H. pylori infection, and metabolic syndrome were 20.84%, 61.77%, 35.91%, and 60.15%, respectively. Multivariate analysis showed that the independent risk factors for reflux esophagitis included IgG-mediated food intolerance (OR = 1.688, 95%CI: 1.497-1.903, P < 0.00001) and metabolic syndrome (OR = 1.165, 95%CI: 1.030-1.317, P = 0.01484), and the independent protective factor for reflux esophagitis was H. pylori infection (OR = 0.400, 95%CI: 0.351-0.456, P < 0.00001). IgG-mediated food intolerance had a partially positive mediating effect on H. pylori infection as it was associated with reduced occurrence of reflux esophagitis (P = 0.0200). Metabolic syndrome had a partially negative mediating effect on H. pylori infection and reduced the occurrence of reflux esophagitis (P = 0.0220).

CONCLUSION

Patients with IgG-mediated food intolerance and metabolic syndrome were at higher risk of developing reflux esophagitis, while patients with H. pylori infection were at lower risk. IgG-mediated food intolerance reduced the risk of reflux esophagitis pathogenesis in patients with H. pylori infection; however, metabolic syndrome increased the risk of patients with H. pylori infection developing reflux esophagitis.
Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma
Authors: Wang Ren-Yong , Yang Jia-Ling , Xu Ning , Xu Jia , Yang Shao-Hua , Liang Dao-Ming , Li Jin-Ze , Zhu Hong
Published: February 2024

BACKGROUND

Hepatocellular carcinoma (HCC) is one of the most common types of tumors. The influence of lipid metabolism disruption on the development of HCC has been demonstrated in published studies.

AIM

To establish an HCC prognostic model for lipid metabolism-related long non-coding RNAs (LMR-lncRNAs) and conduct in-depth research on the specific role of novel LMR-lncRNAs in HCC.

METHODS

Correlation and differential expression analyses of The Cancer Genome Atlas data were used to identify differentially expressed LMR-lncRNAs. Quantitative real-time polymerase chain reaction analysis was used to evaluate the expression of LMR-lncRNAs. Nile red staining was employed to observe intracellular lipid levels. The interaction between RP11-817I4.1, miR-3120-3p, and ATP citrate lyase (ACLY) was validated through the performance of dual-luciferase reporter gene and RIP assays.

RESULTS

Three LMR-lncRNAs (negative regulator of antiviral response, RNA transmembrane and coiled-coil domain family 1 antisense RNA 1, and RP11-817I4.1) were identified as predictive markers for HCC patients and were utilized in the construction of risk models. Additionally, proliferation, migration, and invasion were reduced by RP11-817I4.1 knockdown. An increase in lipid levels in HCC cells was significantly induced by RP11-817I4.1 through the miR-3120-3p/ACLY axis.

CONCLUSION

LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients, and the discovery of a novel LMR-lncRNAs, RP11-817I4.1, revealed its role in promoting lipid accumulation, thereby accelerating the onset and progression of HCC.
desafíos de las relaciones laborales ante la inteligencia artificial
Authors: Delgue Juan Raso
Published: February 2024

El creciente impacto de la Inteligencia Artificial en las relaciones laborales obliga a los Estados y a las organizaciones de empleadores y trabajadores ha enfrentar nuevos desafíos, para los cuales no estamos siempre preparados. Reconocemos ese impacto en la gestión de la empresa, en los ritmos de producción cada vez más estresantes, en los controles sobre los trabajadores cada vez más intensos, en la sustitución de trabajos tradicionales por la acción de los robots.

El legislador no logra seguir el paso de las nuevas tecnologías, por lo cual es necesario recurrir a nuevas fuentes de derecho, como lo principios generales y laborales, el derecho comparado y las normas sobre protección de datos. En este proceso es indispensable despertar el interés de empleadores y trabajadores para abrir espacios de diálogo y negociación.
Türk Siyasal Hayatında Propaganda Müzikleri
Authors: Ürün Tolga , Akgün Emre , Giray Mehmet Zeki , Dağdeviren Mustafa
Published: February 2024

1970’li Yıllarda Türk Siyasal Hayatında Propaganda
Amaçlı Müzik Kullanımı
Tolga ÜRÜN
1980’li Yıllarda Türk Siyasal Hayatında Propaganda
Amaçlı Müzik Kullanımı
Derya KARABURUN DOĞAN
Caner ÇAKI
1990’lı Yıllarda Türk Siyasal Hayatında Propaganda
Amaçlı Müzik Kullanımı
Emre AKGÜN
2000’li Yıllarda Türk Siyasal Hayatında Propaganda
Amaçlı Müzik Kullanımı
Mehmet Zeki GİRAY
2010’lu Yıllarda Türk Siyasal Hayatında Propaganda
Amaçlı Müzik Kullanımı
Mustafa DAĞDEVİREN
Türk Siyasal Hayatında Ropaganda Müzikleri
Derya KARABURUN DOĞAN
Caner ÇAKI
Medisinal Kimya Kısa Bir Giriş
Authors: Alp Mehmet , Alp A. Selen
Published: February 2024

Medisinal kimya, en kısa tanımıyla yeni ilaç etkin maddelerinin tasarımı ve sentezini konu alan ve bunu yaparken de ilaç etkin maddeleri ile ilaç hedefleri arasındaki etkileşimleri moleküler düzeyde anlamayı temel alan bir bilim dalıdır. Ülkemizde eczacılık fakültelerindeki eczacılık meslek bilimlerinden biri olan farmasötik kimya anabilim dalı öğretim üyeleri tarafından eczacılık lisans ve lisansüstü öğrencilerine farmasötik kimya, medisinal kimya, ilaç etkin maddesi tasarımı ve geliştirilmesi vb. dersler kapsamında okutulmaktadır. Bununla birlikte medisinal kimya tıp, biyoloji, moleküler biyoloji, genetik, kimya, kimya mühendisliği gibi pek çok bölümdeki akademisyen ve öğrencilerin yanısıra ilaç sanayisinde araştırma-geliştirme (Ar-Ge) bölümü çalışanlarını doğrudan, ilaçları doktor tarafından reçetelendikten sonra eczaneden temin ederek kullanan toplumdaki tüm bireyleri ise dolaylı olarak ilgilendiren bir konudur.
Matematik ve Fen Eğitimi Araştırmaları I
Authors: Çelen Yeliz , Kubanç Yasemin , Dilek Eren Canan , Saygılı Gizem , Ersoy Yaşar , Erdem Aytekin , Domaç Gonca Gül , Gül Ali , Kobak Demir Mevhibe
Published: February 2024

Aday Öğretmenlerin Matematiğe Yönelik Tutumlarının Etkinlik Temelli Matematik Öğretimine Yönelik Görüşlerine Etkisi
Yeliz ÇELEN
Öğretmenlerin Matematiğe Yönelik Tutumları
Yeliz ÇELEN
Diskalkuli Nedir? What is Dyscalculia?
Yasemin KUBANÇ
Diskalkuli Nasıl Tespit Edilebilir? How is dyscalculia detected?
Yasemin KUBANÇ
Öğretmen Adaylarının Fen Metinlerini Okumaya Yönelik Tutumlarının Çeşitli Değişkenler Açısından İncelenmesi
Canan DİLEK EREN
Öğretim Teknolojileri Destekli Fen Öğretimi Üzerine Bir Değerlendirme
Gizem SAYGILI
Fen Bilgisi/Fizik Öğretmenlerinin Gelişimi: Öğretmenlerin Yeni Rolleri ve Sürekli Gelişmeleri
Yaşar ERSOY
Aytekin ERDEM
Argümantasyon Tabanlı Öğrenme Sürecinin Toplumbilimsel
Konuların Öğrenilmesindeki Etkisi
Gonca Gül DOMAÇ
Ali GÜL
Matematik Öğretiminde Grafik Örgütleyicilerin Kullanımı: KWL Ve KNWS
Mevhibe KOBAK DEMİR
Temel İşletmecilik Bilgisi
Authors: Özgen Hüseyin , Yalçın Azmi
Published: February 2024

Bu kitapta; bir işletmenin yerine getirdiği üretim, pazarlama, finansman, insan kaynakları fonksiyonları ile yönetim, örgütleme, rekabet, kalite ve diğer konulara ilişkin ilke ve teknikler, kar amacı güden bir işletme temel alınarak açıklanmaktadır. Bununla birlikte, kitapta ele alınan konulara ilişkin ilke ve teknikler, kar amacı gütmeyen işletmelerde de büyük ölçüde geçerlidir.
Basketbolda Hücum
Authors: Erdoğan Bülent
Published: February 2024

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New online project “Collectors of The Russian Museum of Ethnography”: concept, preliminary results
Authors:   The Russian Museum of Ethnography, St. Petersburg, Fishman Olga M.
Published: February 2024

The article contains a presentation of the concept and preliminary results of the new virtual project "Collectors of the Russian Ethnographic Museum", launched in 2021. Its purpose is to recreate individual portraits of scientists, correspondents and museum staff, personal and creative biographies of those who during the XIX — early XXI c., and were associated with the museum field. The fates of some of them are quite well known, others are little studied due to various circumstances. It's not just the famous specialists (ethnographers, linguists, folklorists, archaeologists, historians, etc.) and correspondents, but also representatives of different social circles, scientific and political views, levels of education, nationalities, confessions, ages, characters; with different motivation for ethnographic research and subjective approaches to their own collecting activities. Currently, according to the concept and well-thought-out scheme, materials about more than 130 people have been published, more than 30 museum employees participated in their creation. URL:https://ethnomuseum.ru/collections/projects/collectors/.
Family history reflected in the archives of families with german roots
Authors:   Barents Centre of the Humanities of the Kola Science Centre of the Russian Academy of Sciences, Busyreva Elena V.
Published: February 2024

The article is devoted to archives kept in families with German roots. Interest in them is due to the fact that they contribute to the study of the history of everyday life as an individual representative of the genus, and the community as a whole. Archives were created in order to preserve the memory of the history of the family for posterity. The data on tribal and family archives are presented. Five generic and ten family archives have been presented. The composition of the archives is reviewed in the article. The composition of the archives indicates which documents are significant for the family. The archive materials contain interesting information and can be used as a source for studying the history of family-related communities with German ancestry.
Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells
Authors: Ishikawa Fumihiro , Konno Sho , Kakeya Hideaki , Tanabe Genzoh
Published: February 2024

The adenylation (A) domain is essential for non-ribosomal peptide synthetases (NRPSs), which synthesize various peptide-based natural products, including virulence factors, such as siderophores and genotoxins. Hence, the inhibition of A-domains could attenuate the virulence of pathogens. 5’-O-N-(Aminoacyl or arylacyl)sulfamoyladenosine (AA-AMS) is a bisubstrate small-molecule inhibitor of the A-domains of NRPSs. However, the bacterial cell permeability of AA-AMS is typically a problem owing to its high hydrophilicity. In this study, we investigated the influence of a modification of 2′-OH in the AMS scaffold with different functional groups on binding to target enzymes and bacterial cell penetration. The inhibitor 7 with a cyanomethyl group at 2′-OH showed desirable inhibitory activity against both recombinant and intracellular gramicidin S synthetase A (GrsA) in the gramicidin S-producer Aneurinibacillus migulanus ATCC 9999, providing an alternative scaffold to develop novel A-domain inhibitors.
Analisis Semiotik Roland Barthes pada Film Animasi Nussa dan Rara Episode 1 sampai 5
Authors: Santoso Imam , Irwansyah Irwansyah
Published: February 2024

Currently, da'wah activities are not only carried out using conventional media, but also use other media such as social media and the internet, one of which is the social media YouTube, a social media that shows the animated series Nussa with an Islamic theme. This research aims to find out what Islamic values ​​are contained in the animated series Nussa episodes 1-5. The type of research used is descriptive qualitative research. The analytical method used is Roland Barthes' semiotic analysis method. Data collection techniques are carried out using observation and documentation. Meanwhile, the data analysis technique is Roland Barthes' semiotic analysis. Barthes' theory divides signs based on signifier and signified then produces denotation, connotation and myth. The Islamic values ​​or da'wah messages contained in each film episode can be identified as elements of da'wah after being analyzed using Roland Barthes' theory. The overall results of this research found that the message of da'wah or Islamic values ​​contained in each episode of this film is courage, cleanliness, manners or ethics, helping others, giving charity, conveying knowledge, sincerity. Which are grouped based on the main aspects of Islamic values, namely moral values, aqidah values ​​and sharia values.
SÍNTESIS DE NANOPARTÍCULAS CU-AG SOBRE TITANIO COMO CÁTODO PARA LA REDUCCIÓN ELECTROQUÍMICA DE NITRATO EN SOLUCIONES ACUOSAS
Authors: La Rosa-Toro Gómez Adolfo , Allcca Castillo Yenny M. , Martins de Godoi Denis Ricardo , Jauja Ccana Victor R. , Sánchez Sánchez Carlos M.
Published: February 2024

La contaminación por nitrato constituye una seria problemática medioambiental y de salud humana. En este estudio, se investigó la Reducción Electroquímica de Nitrato (REN) mediante el desarrollo de nuevos cátodos basados en nanopartículas de Cu-Ag recubiertas sobre Titanio (Cu-Ag /Ti). Las nanopartículas se sintetizaron utilizando la técnica de desplazamiento galvánico y se caracterizaron mediante espectroscopía UV-Vis y dispersión de luz dinámica (DLS).La preparación del cátodo consistió en recubrir con las nanopartículas una placa de titanio pretratado y se caracterizó mediante microscopía electrónica de barrido de emisión de campo (FE-SEM), espectroscopía de energía dispersiva (EDS) y medidas electroquímicas. Las imágenes FE-SEM mostraron partículas esféricas de tamaño menores ≤ 100 nm, con indicios de estabilidad después de 40 horas de reacción. La composición atómica determinada por EDS fue de 6/1 (Cu/Ag). La caracterización electroquímica mostró una mayor electrocatálisis en el cátodo propuesto evaluado en solución de 100 mg L-1 NO3-N + 0,03 M Na2SO4, contraelectrodo IrOx/Ti, electrodo de referencia Ag/AgCl (3 M).Mediante cronopotenciometría con densidad de corriente 20 mA cm-2 durante 5 horas, se compararon los cátodos: placa de Titanio (Ti), nanopartículas de Cu sobre Titanio (Cu/Ti) y Cu-Ag /Ti-N2. La REN evaluada con Ti, Cu/Ti, Cu-Ag /Ti (N1 y N2) a 40 mA cm-2, reactor de 1-celda de 50 mL por 3,5 horas se obtuvo una reducción de %NO3-N en 22,62, 28,28, 38,58 y 47,61% respectivamente.
Explanatory models of illness in schizophrenia: A narrative review
Authors:   Department of Child and Adolescent Psychiatry, “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Grosu Stefania-Alexandra ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: February 2024

This article provides a comprehensive review of the explanatory models of illness present in schizophrenic patients with diverse cultural backgrounds. Explanatory models are culturally determined beliefs regarding concepts such as health and illness and are key to understanding how patients integrate their illness experience within their cognitive framework, giving perceived meaning to their illness episodes and influencing their treatment choices. The results reveal significant cultural differences in the interpretation of schizophrenia, with Eastern cultures attributing more importance to spiritual and esoteric factors compared to Western ones. These cultural distinctions affect treatment approaches and patient - practitioner relationships, with a notable trend towards explanatory pluralism in many societies. This review stresses the need for medical practitioners to adapt their approach to accommodate cultural differences and patient-specific factors, emphasizing the importance of compatibility between patient and healthcare practitioner models, and highlighting the potential discordance in perspectives that can impact treatment effectiveness.
Evaluasi Efektivitas Metode Pembelajaran Berbasis Proyek dalam Mengembangkan Kreativitas Siswa
Authors: Taliak Jeditia , Al Farisi Taufiq , Sinta Riska Aprilia , Aziz Abdul , Fauziyah Nur Laily
Published: February 2024

Metode pembelajaran berbasis proyek telah menjadi perhatian utama dalam perkembangan pendidikan masa kini, khususnya dalam upaya meningkatkan kreativitas siswa. Penelitian ini bertujuan untuk menganalisis efektivitas metode pembelajaran berbasis proyek dalam mengembangkan kreativitas siswa pada jenjang pendidikan menengah. Pendekatan penelitian menggunakan studi kasus dengan partisipasi siswa sekolah menengah di berbagai lokasi. Data dikumpulkan melalui observasi, wawancara dan kuesioner yang dianalisis menggunakan metode kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa metode pembelajaran berbasis proyek secara signifikan meningkatkan kreativitas siswa dalam berbagai aspek. Proses kolaboratif dalam menyelesaikan proyek memungkinkan siswa untuk mengembangkan pemikiran kritis, pemecahan masalah, dan keterampilan inovasi. Selain itu, metode ini memberikan kesempatan kepada siswa untuk menerapkan pengetahuannya dalam konteks nyata, sehingga memicu minat dan motivasi belajar yang lebih tinggi. Namun penelitian ini juga mengidentifikasi beberapa tantangan dalam penerapan metode pembelajaran berbasis proyek, seperti kurangnya sumber daya, keterbatasan waktu, dan kesulitan dalam mengevaluasi kinerja siswa secara holistik. Oleh karena itu, disarankan agar pendekatan ini didukung oleh dukungan kuat dari sekolah, pengembangan kurikulum yang relevan, dan pelatihan bagi guru dalam merancang dan mengelola proyek pembelajaran.
O Bônus fiscal dos estados e a política macroeconômica
Authors: Pires Manoel Carlos de Castro
Published: February 2024

O texto discute os efeitos da pandemia na situação fiscal dos estados brasileiros, destacando uma significativa melhora em 2021, o que contribuiu para o resultado primário positivo do setor público, o primeiro desde 2013. No entanto, ressalta-se que essa melhoria fiscal vem acompanhada de pressões políticas que transformaram o excedente fiscal em financiamento para ações macroeconômicas. O estudo busca explicar esse fenômeno e como a política macroeconômica se beneficia dessa situação para alcançar seus objetivos. No entanto, alerta para a necessidade de temperança nesse processo, enfatizando a importância de respeitar as prioridades dos estados e reconhecer que parte desse espaço fiscal foi obtido mediante decisões não sustentáveis, como a redução dos investimentos e dos gastos com pessoal. Portanto, sugere a conciliação dessas questões para evitar uma nova deterioração fiscal após anos de esforço na construção de um sistema fiscal federativo mais robusto.
Picos, vales e ciclos: qual o comportamento do investimento entre 1996 e 2020?
Authors: Cruz Bruno de Oliveira , Cavalcanti João Pedro
Published: February 2024

O texto indica que, mesmo antes da pandemia, a renda per capita no Brasil estava estagnada ou em leve queda, levantando preocupações sobre o desempenho econômico de longo prazo do país. Autores como Bonelli e Bacha destacam a importância de aumentar a taxa de investimento para promover um crescimento consistente, sugerindo que um aumento de 1% na taxa de investimento pode impulsionar o crescimento do PIB em 0,4%. Políticas regionais de estímulo ao investimento, como aquelas implementadas no Japão, mostraram-se eficazes, especialmente em áreas tecnológicas. Uma análise detalhada dos dados da Pesquisa Industrial Anual revelou uma concentração significativa de investimentos em poucos períodos e setores, como a indústria extrativa mineral e o refino de petróleo, levantando questões sobre a natureza dos picos de investimento, sua relação com o ciclo econômico e sua influência no comportamento macroeconômico. O estudo destaca a necessidade de entender melhor os determinantes desses picos de investimento e seu impacto, abrindo espaço para pesquisas futuras e destacando sua relevância para formuladores de políticas públicas.
Distribuição regional do valor bruto da produção (VBP) pecuária no Brasil
Authors: Freitas Rogério Edivaldo
Published: February 2024

A estratégia de modernização agropecuária desde os anos 1960 no Brasil, apoiada por políticas públicas como crédito subsidiado, impulsionou a produção em larga escala. No entanto, durante os anos 1980, o modelo enfrentou desafios, incluindo redução de crédito, recessão e queda nos preços das commodities. A produção de cana-de-açúcar e de produtos de exportação foi incentivada, enquanto a abertura da economia na década seguinte trouxe competição externa e instabilidade inflacionária. Após a estabilização monetária em 1994, a renda real aumentou, impulsionando a demanda por alimentos proteicos, atendida pela produção pecuária nacional. Apesar das dificuldades, o setor se consolidou, tornando-se cada vez mais integrado e profissionalizado. A pecuária, em particular, desempenha um papel relevante na produção agropecuária brasileira, representando 30,6% do valor do segmento em 2020. Além disso, as exportações de carnes e lácteos têm crescido, destacando a importância do setor para a geração de receitas cambiais. Este estudo visa avaliar a contribuição das diferentes regiões brasileiras para a produção pecuária nacional ao longo do período de 2011 a 2020.
O Trabalho remoto no primeiro período da pandemia de Covid-19: uma análise para o nordeste
Authors: Martins Felipe dos Santos , Góes Geraldo Sandoval , Nascimento José Antônio Sena
Published: February 2024

No início da pandemia da Covid-19 no Brasil, medidas de distanciamento social foram adotadas visando reduzir a disseminação do vírus, o que resultou na diminuição da circulação de pessoas e na queda da atividade econômica, ocasionando aumento do desemprego, afastamentos temporários e adoção do trabalho remoto. O país implementou a Pesquisa Nacional por Amostra de Domicílios (PNAD) Covid-19 para monitorar os efeitos da pandemia sobre o trabalho e a saúde da população. Este estudo visa avaliar esses impactos na região Nordeste em comparação com o restante do Brasil durante o primeiro período da pandemia. Antecipa-se que os índices de afastamento e trabalho remoto possam ser inferiores no Nordeste devido às características ocupacionais da população da região. A pesquisa baseia-se nos achados de estudos anteriores e é estruturada em cinco seções: introdução, metodologia, dados descritivos, resultados dos modelos econométricos e conclusão.
Proposta de pesquisa: mobilidade produtiva e infraestrutura logística
Authors: Caldeira Valquíria Cardoso , Vieira Filho José Eustáquio Ribeiro
Published: February 2024

O texto destaca a importância da agricultura brasileira no cenário internacional, evidenciando seu crescimento nas exportações de produtos agropecuários em 2021, alcançando um recorde histórico. Apesar dos avanços e modernização do setor, observa-se uma heterogeneidade na distribuição de renda, com concentração significativa de renda em uma pequena parcela dos estabelecimentos rurais. Essa desigualdade é atribuída, em parte, a imperfeições de mercado que dificultam o acesso dos pequenos produtores à tecnologia e recursos necessários para aumentar sua produtividade. Além disso, as deficiências na infraestrutura logística do país impactam a rentabilidade da produção agrícola e a competitividade internacional do setor. Diante desse contexto, a pesquisa propõe investigar se houve promoção da mobilidade produtiva dos agricultores mais pobres entre 2006 e 2017 e se regiões com maior mobilidade produtiva investem mais em infraestrutura.