bluuebunny/crossref_metadata_2025 huggingface dataset:
Urinary fatty acid biomarkers for prostate cancer detection
Authors: Noriega Landa Elizabeth , Quaye George E. , Su Xiaogang , Badmos Sabur , Holbrook Kiana L. , Polascik Thomas J. , Adams Eric S. , Deivasigamani Sriram , Gao Qin , Annabi Michael H. , Habib Ahsan , Lee Wen-Yee
Published: February 2024

The lack of accuracy in the current prostate specific antigen (PSA) test for prostate cancer (PCa) screening causes around 60–75% of unnecessary prostate biopsies. Therefore, alternative diagnostic methods that have better accuracy and can prevent over-diagnosis of PCa are needed. Researchers have examined various potential biomarkers for PCa, and of those fatty acids (FAs) markers have received special attention due to their role in cancer metabolomics. It has been noted that PCa metabolism prefers FAs over glucose substrates for continued rapid proliferation. Hence, we proposed using a urinary FAs based model as a non-invasive alternative for PCa detection. Urine samples collected from 334 biopsy-designated PCa positive and 232 biopsy-designated PCa negative subjects were analyzed for FAs and lipid related compounds by stir bar sorptive extraction coupled with gas chromatography/mass spectrometry (SBSE-GC/MS). The dataset was split into the training (70%) and testing (30%) sets to develop and validate logit models and repeated for 100 runs of random data partitioning. Over the 100 runs, we confirmed the stability of the models and obtained optimal tuning parameters for developing the final FA based model. A PSA model using the values of the patients’ PSA test results was constructed with the same cohort for the purpose of comparing the performances of the FA model against PSA test. The FA final model selected 20 FAs and rendered an AUC of 0.71 (95% CI = 0.67–0.75, sensitivity = 0.48, and specificity = 0.83). In comparison, the PSA model performed with an AUC of 0.51 (95% CI = 0.46–0.66, sensitivity = 0.44, and specificity = 0.71). The study supports the potential use of urinary FAs as a stable and non-invasive alternative test for PCa diagnosis.
Revisiting functioning recovery in persons with spinal cord injury undergoing first rehabilitation: Trajectory and network analysis of a Swiss cohort study
Authors: Hodel Jsabel , Sabariego Carla , Galvis Aparicio Mayra , Scheel-Sailer Anke , Seijas Vanessa , Ehrmann Cristina
Published: February 2024

Information about an individual’s functioning and its longitudinal development is key to informing clinical rehabilitation. However, the description and understanding of the detailed longitudinal course of functioning, i.e., functioning trajectories, is rare in the current SCI literature. The aim of this study was to re-estimate previously identified functioning trajectories of individuals with spinal cord injury (SCI) undergoing initial rehabilitation in Switzerland using trajectory analysis, and to identify highly influential functioning domains that could become trajectory-specific targets for clinical interventions using network analysis. The study was based on data from the Swiss SCI Cohort Study and included individuals with SCI (N = 1099) who completed their rehabilitation in one of four collaborating centers between May 2013 and March 2022. For the trajectory analysis, functioning was operationalized using the total sum score of the Spinal Cord Independence Measure version III (SICM III), which was assessed at up to four time points (T1-T4) during rehabilitation. For the network analysis, individual SCIM III items were used to operationalize relevant functioning problems at T1 (admission) and T4 (discharge). The re-estimation of trajectory analysis confirmed the previously identified mean functioning trajectory classes of stable high functioning (N = 239; 21.75%), early (N = 33; 3.00%), moderate (N = 753; 68.52%), and slow (N = 74; 6.73%) functioning improvement. The network analysis revealed highly connected functioning problems at T1 for the moderate functioning improvement class, including "Feeding", "Dressing upper body", and "Dressing lower body", "Mobility in bed", and "Use of toilet". These functioning domains might indicate potential trajectory-specific targets for clinical interventions. This study has increased our knowledge about functioning trajectories of individuals with SCI undergoing initial rehabilitation in Switzerland and its findings may inform discussions about the application and use of functioning trajectories in clinical practice. Due to the exploratory nature of this study, further research is needed to confirm the findings presented.
Experimental study of precursory features of CO2 blasting-induced coal rock fracture based on grayscale and texture analysis
Authors: Pan Hongyu , Wang Haotian , Wang Kang , Zhang Tianjun , Ji Bing
Published: February 2024

CO2blasting has been identified as a potent method for enhancing the permeability of coal seams and improving gas drainage efficiency. This study is focused on elucidating the deformation and fracture mechanisms of coal and rock during CO2blasting and on identifying the precursor characteristics of these processes. To this end, a CO2blasting-induced coal rock fracture pressure model and a gas pressure distribution model were developed. The research utilized a self-developed CO2blasting test platform along with a non-contact full-strain field measurement analysis system. Briquette samples were subjected to CO2blasting tests under controlled experimental conditions, which included an axial pressure of 1.0 MPa and variable gas pressures of 0.5, 1.0, and 1.5 MPa. This methodology enabled the capture of the principal strain field on the surface of the samples. The Gray Level Co-occurrence Matrix (GLCM) was employed to extract and analyze the grayscale and texture features of the strain cloud maps, facilitating a quantitative assessment of their evolution. The aim was to pinpoint the precursor characteristics associated with coal rock cracking and crack propagation. The results revealed that: (1) During the cracking and subsequent propagation of samples, the strain field’s grayscale histogram underwent a transformation from a “broad and low” to a “narrow and high” configuration, with a consistent increase in peak frequency. Specifically, at 3 ms, a primary crack was observed in the sample, evidenced by a grayscale peak frequency of 0.0846. By 9 ms, as the crack propagated, the grayscale peak frequency escalated to 0.1626. (2) The texture feature parameters experienced their initial abrupt change at 3ms. Correlation with the gas pressure distribution model indicated that this was the crack initiation moment in the sample. (3) A secondary abrupt shift in the texture feature parameters occurred at 9ms, in conjunction with experimental phenomena, was identified as the crack propagation phase. Monitoring the grayscale and texture features of the principal strain field on the coal rock surface proved effective in recognizing the precursor characteristics of crack initiation and propagation. This research has the potential to reduce blasting costs in coal mines, optimize blasting effects, and provided theoretical guidance for enhancing gas extraction efficiency from deep and low permeability coal seams.
Modernizing music programmes in higher education with popular music: Students’ preparation for music employment
Authors: Foley Smith Christin , Brodie Russell
Published: February 2024

This qualitative study explored the need to modernize music programmes in higher education with popular music to prepare graduates for twenty-first-century employment. Researchers agreed that popular music studies will allow students to gain valuable knowledge and use their degree in complex systems in various music professions. This study utilized Tyler’s Basic Principles of Curriculum and Instruction Rationale Model to discover what students need to be successful in a music career, with consideration of modern-day influences and popular music. Ten interviews were conducted with professionals in various music careers to raise awareness of music employment and the need for change in higher education to support life post-graduation. The findings showed a consensus that popular music should be added to the music curriculum. Future research recommendations include surveying students regarding their musical interests and influences, implementing popular music within the traditional curriculum and application-based learning.
Revisiting Sylvia Plath’s The Bell Jar as a feminist response to McCarthyism
Authors: Arce Álvarez María Laura
Published: February 2024

The present article introduces a feminist and political analysis of Sylvia Plath’s novel The Bell Jar, considering it a cultural response to McCarthyism. In order to do that, the article focuses on the importance Plath gives to the Rosenberg’s case in the novel and particularly in the relevance Ethel Rosenberg’s death sentence had to awaken a female consciousness for the women of the 1950s in America. The female body turns fundamental for a feminist struggle that Plath creates in the novel to deconstruct the imposed female roles that helped McCarthy control the private lives of the Americans. Sixty years after Plath’s death and its publication, The Bell Jar becomes a fundamental text for understanding contemporary feminist literature.
Ensemble Learning Approach for Effective Software Development Effort Estimation with Future Ranking
Authors: Eswara Rao K. , Pydi Balamurali , Annan Naidu P. , Prasann U. D. , Anjaneyulu P.
Published: February 2024

To provide a client with a high-quality product, software development requires a significant amount of time and effort. Accurate estimates and on-time delivery are requirements for the software industry. The proper effort, resources, time, and schedule needed to complete a software project on a tight budget are estimated by software development effort estimation. To achieve high levels of accuracy and effectiveness while using fewer resources, project managers are improving their use of a model created to evaluate software development efforts properly as a decision-support system. As a result, this paper proposed that a novel model capable of determining precise accuracy of global and large-scale software products be developed with practical efforts. The primary goal of this paper is to develop and apply a practical ensemble approach for predicting software development effort. There are two parts to this study: the first phase uses machine learning models to extract the most useful features from previous studies. The development effort is calculated in the second phase using an advanced ensemble method based on the components of the first phase. The performance of the developed model outperformed the existing models after a controlled experiment was conducted to develop an ensemble model, evaluate it, and tune its parameters.
#Fuimostodas. Voces contradiscursivas del movimiento feminista mexicano
Authors: Sinche Morocho Narcisa , Verdú Delgado Ana Dolores
Published: February 2024

En este artículo analizamos el hashtag #FuimosTodas, las condiciones que lo originaron, su resignificación en el contexto de conflicto entre el movimiento feminista y el Estado mexicano, y también sus repercusiones. Nos centramos en el modo en que el hashtag, además de constituir una potente herramienta simbólica para el feminismo por su capacidad de articular una subjetividad política, funciona como catalizador de una voluntad popular que condensa diferentes experiencias y sentidos.
Don Quijote el Escolástico
Authors: Centeno Pedro
Published: February 2024

Don Quijote el Escolástico (1788-1789) merecería ser el segundo de este nombre entre todas las continuaciones e imitaciones españolas del Quijote cervantino (si no fuera por la envergadura de la Historia de Fray Gerundio de Campazas, del padre Isla, que lo precedió), tal y como lo quería su autor, el teólogo agustino Pedro Centeno, cuya vida y obra se traza con detalle en la introducción de este volumen. En esta obra, de la que se ofrece aquí la primera edición moderna, un nuevo avatar de don Quijote se determina a ir de escuela en escuela como caballero escolástico; se encuentra con un anciano vestido de verde y unos franceses; visita una cátedra de química y el Gabinete de Historia Natural; da con un poeta tan quijotesco por desvariado como nuestro protagonista y con un capitán, encarnación de la racionalidad y el sentido común ilustrados, un episodio que culmina con una «batalla libresca»; y acaba sus andanzas de manera abrupta cuando desaparece por temor a la justicia. El autor-historiador aprovechará entonces para narrar el escrutinio y quema de la librería de don Quijote el Escolástico por el cura y el sacristán, motivo que le sirve a Centeno para reiterar sus ataques a la obra contra la que se dirige el dispositivo quijotesco, la Summa Philosophica del italiano Salvatore Roselli (un mamotreto antediluviano con el que se pretendió renovar la escolástica y detener con ella los avances científicos, humanos y sociales). Como pone de manifiesto el estudio que acompaña el texto de Centeno, estamos ante la sátira más ingeniosa, acerada y contundente contra el movimiento reaccionario y en defensa de la continuidad de la Ilustración española de las que se escribieron en nuestro XVIII y es, sin duda, fuera de clasificaciones, una de las más brillantes y desatadas de nuestra literatura.
"… a vízben kell elmerítenem majd feloldanom a verset" Haiku értelmezés középiskolásoknál
Authors: Hevesi Tímea Mária
Published: February 2024

Az absztrakt gondolkodás szintje nagymértékben összefügg a tanulmányi eredménnyel. A magas absztrakt gondolkodási szint alapján jó eredmények várhatóak a matematika és a természettudományok területein (Shayer 1999; Nurjannah, Kusnandi 2020). Az absztrakció folyamatát tekintik a számítástechnikai gondolkodás magjának (Zehetmeier et al. 2019). Az absztrakt gondolkodással rendelkező tanulók képesek deduktív és induktív módon gondolkodni, tudják elemezni a lehetőségeket és jól hasznosítják az absztrakt gondolatokat (Velasquez 2013). Magas fokú absztrakcióval jár a szimbólumok értelmezése (Kapitány, Kapitány 2020). Szepes (2014) úgy véli, hogy a haiku műfajban írt költeményben a verset éppen szimbolikus képi jellege teszi műfajilag haikuvá, amikor a vers érzékileg észlelhető képi síkja mögött meghúzódik egy átvitt, gondolati sík is.

Kutatásunkban az absztrakt gondolkodást vizsgáljuk középiskolás fiatalok haiku értelmezései alapján. Fodor Ákos Elkészítési javaslat című, haiku műfajban írt költeményében a víz szimbólumának értelmezését elemezzük három szegedi gimnáziumban tanuló 449 középiskolás válasza nyomán. Vizsgálatunkat a témában végzett, a KAPOCS Kutatócsoport 2022-es olvasáskutatásának adatai alapján végezzük el.

Kutatásunkban arra keressük a választ, hogy a középiskolás tanulók milyen típusú és mennyiségű elvont fogalmat használtak a víz szimbólumának az értelmezésénél? Az elvont fogalmak használatának gyakorisága kapcsolatban van-e könyvolvasási szokásaikkal?
Implementation of a Hepatocellular Carcinoma Surveillance Program in a Community-Based Integrated Health System in Patients With Hepatitis C Cirrhosis
Authors: Bui Hien , Kumar Nikhilesh G. , Singal Amit G. , Boparai Jasdeep , Mukhtar Nizar A. , Tran Don , Saxena Varun , Balasubramanian Sripriya
Published: February 2024

INTRODUCTION:

Underutilization of hepatocellular cancer (HCC) surveillance has been reported, although data evaluating interventions to improve surveillance are sparse. We assessed the effect of a population-based HCC surveillance program on HCC surveillance utilization and outcomes.

METHODS:

In this retrospective cohort study, we assessed preinclusion and postinclusion HCC surveillance patterns among 597 patients with hepatitis C virus cirrhosis enrolled in a program at an integrated health system between 2013 and 2020. Adequate surveillance was defined as at least 5 surveillance studies within 36 months pre-enrollment and postenrollment; a secondary outcome was proportion of time covered by surveillance over 36 months. Tumor size, stage, and receipt of curative therapy were compared between HCC detected on the first imaging examination (prevalent HCC) and surveillance-detected HCC (incident HCC). We performed Kaplan-Meier analysis and multivariable competing risk analysis to characterize the association between surveillance and mortality.

RESULTS:

The surveillance program significantly improved surveillance completion (77.6% vs 5.0%, P < 0.001) and proportion time covered (80.9% vs 15.8%, P < 0.001). Compared with prevalent HCC, surveillance-detected cases were more likely unifocal (77.8% vs 44.8%, P < 0.001), early-stage (85.2% vs 44.8%, P < 0.001), with smaller maximum diameter (median 2.3 vs 3.2 cm), and more likely to undergo curative therapy (92.5% vs 72.4% P = 0.010). Survival was improved compared with prevalent cases hazard ratio (HR) 0.23 (0.11–0.51) after adjusting for age and Model for End Stage Liver Disease score.

DISCUSSION:

Implementation of a population-based program resulted in significant improvement in HCC surveillance use and clinical outcomes among patients with hepatitis C virus cirrhosis. These findings may inform similar interventions by other healthcare systems.
Dafnis y Cloe: rusticitas versus urbanitas
Authors: Mestre Francesca
Published: February 2024

Longo compone su novela, Dafnis y Cloe, con una intención evidente de formar parte del género, del cual conservamos otros ejemplos. A pesar de ello, es necesario notar las singularidades que esta obra tiene en comparación con estos otros ejemplos. El objetivo de este trabajo es resaltar dichas singularidades e intentar justificarlas, siempre siguiendo, hipotéticamente, lo que su autor se propone. Desde el punto de vista de su narratología, se sirve, como es habitual en el género, de la formación en los προγυμνάσματα que recibían los πεπαιδευμένοι en las escuelas de rétores y sofistas: narración, descripción, etopeya, etc. Sin embargo, Longo utiliza de forma notoria otro ejercicio menos habitual, la σύγκρισις, hasta el punto que todo su relato pivota alrededor de esos paralelos, tanto a la hora de explicar el nacimiento y la esencia del sentimiento amoroso recíproco entre la pareja de protagonistas, como cuando defiende, por un lado, el aspecto más natural de ese sentimiento, el amor en ámbito rural y, por otro, cuando le pone en paralelo las exigencias que las convenciones urbanas han establecido para legitimar la unión de una pareja heterosexual y, en consecuencia, la formación de una familia. Así, esta σύγκρισις ἀγροῦ καὶ πόλεως es aplicada al amor, y seguramente da al autor la oportunidad de ir más allá de la simple presentación de una historia de amor, sazonada de peripecias hasta su consumación.
Numerical study on discharge capacity of piano key side weir with various ratios of the crest length to the width
Authors: Alabedi Hiba Jameel , Khassaf Saleh Issa
Published: February 2024

A side or lateral weir can be defined as a longitudinal weir put in parallel to the main flow direction. A piano key side weir (PKSW) is one of the various side weirs used to control flow level, flow diversion, and flood harm prevention in dams and hydraulic systems. A side weir aims to keep the water level in the main channel at a specific level by discharging the overflow water into a side channel. The discharge coefficient of the PKSW was covered in this study by numerical modeling of a rectangular PKSW type B with various ratios of the crest length to the width in a straight channel. Results showed that the discharge coefficient of the PKSW was more affected by the L/W parameter when the other parameters were constant. It was noted that the PKSW discharge coefficient for L/W equal to 6 demonstrated a significantly higher level of performance and also found that increasing the upstream head above the side weir crest (h
a/P) negatively affected the coefficient of discharge. It was concluded that a high capacity of the discharge coefficient required the (h
a/P) ratio to be smaller than 0.75 or within the range (0.3 ≤ h
a/P < 0.75).
Indexical meanings of the realization of /sˤ/ ص as [s] س in spoken and written Jordanian Arabic: a language change in progress?
Authors: Zibin Aseel , Daoud Sumaya , Mitib Altakhaineh Abdel Rahman
Published: February 2024

This study examines how the phonetic realisation of the phoneme /sˤ/ and its orthographic form ص is surfacing as the variant [s] in speaking and as س in writing in Ammani Arabic (AA), which is a variety of Jordanian Arabic (JA), and how this relates to language variation. We look at instances where certain Ammani Arabic speakers, particularly females, pronounce and write words containing /sˤ/ ص as [s] س, despite both /sˤ/ and /s/ being phonemes in JA in general and in AA in particular. We used a quantitative corpus-based approach, where we obtained written data from Facebook, and elicited spoken tokens and qualitative data through interviews. Our findings reveal that females in our two corpora [spoken and written] use and prefer [s] and س more than males, and our interviews revealed that female interviewees also prefer this pronunciation and writing. We suggest that the use of [s] س instead of [sˤ] ص by females can be seen as a direct index for femininity within their community of practice, and that this pronunciation/writing can indirectly index female gender in daily conversations and on social media websites, based on orders of indexicality (Silverstein, Michael. 2003. Indexical order and the dialectics of sociolinguistic life. Language & Communication 23. 193–229).
A study into strain sensor of cement-based material using CPW transmission lines
Authors: Song Chunyan , Li Mo , Zhang Weidong , Wu Xiaodong , Gao Song
Published: February 2024

Based on the theory of coplanar waveguide (CPW) transmission line, a novel microwave non-destructive strain monitoring sensor specifically designed for cement-based material structures is presented in this study. The aim is to establish the relationship between the variation of the S11 phase parameter of the CPW strain sensor and the structural strain, utilizing a linear analysis. The feasibility of the strain monitoring by the CPW sensor is validated through simulations and experiments. The obtained results demonstrate a strong linear correlation between the phase change of the S11 parameter and the strain, with a goodness of fit of 0.987. The simulated strain sensor exhibits a sensitivity of 48.83 ppm/με, while the experimental measurement sensor shows a sensitivity of 65.82 ppm/με. These findings highlight the potential significance of the proposed method, offering a new approach that is characterized by high sensitivity, low cost, and simplicity for strain monitoring in concrete structures. Among them, the sensor cement mortar matrix made in this study was mixed with the recycled material made of waste glass steel FRP after a certain treatment process. The development of this method holds promise for the advancement of health monitoring in concrete structures.
Best practices and future challenges in the treatment of oral cancer
Authors: Kröplin Juliane , Reppenhagen Jil-Charlot
Published: February 2024

Objectives

Oral cancer is among the most common tumour worldwide. Due to the anatomical peculiarities of the head and neck region, the treatment of oral cancer is a major challenge with regard to the preservation of aesthetics and function. The aim of the present study is to analyze currently practiced therapeutic strategies as well as current and future challenges in the therapy of oral cancer.

Methods

A Pubmed-based selective literature search was performed considering literature predominantly from 2021 to 2022. Search terms were “oral cancer,” “oral cavity cancer,” and “head and neck cancer.”

Results

Head and neck tumours are the seventh most common cancer worldwide. The suspected diagnosis of oral cancer is often made by outpatient dentists during routine examinations. With the outbreak of the 2020 COVID 19 pandemic, risk behaviour has changed with regard to the development and diagnosis of oral cancer. The gold standard of therapy is surgical resection. The need for adjuvant therapy measures depends on the histopathological TNM stage and other defined risk factors. Recurrences occur frequently and should be evaluated with regard to renewed surgical therapy. Future treatment strategies are aimed at early diagnosis, precision in resection, the use of digital technologies, and aspects of quality assurance. The economic importance in the treatment of oral cancer is currently given little consideration.

Conclusions

The study presents a selective portfolio of treatment strategies currently practiced in Germany and in many parts of the world. In addition, future challenges in the therapy of oral cancer, in particular squamosa cell carcinoma, are presented.
Groups with subnormal or modular Schmidt 𝑝𝑑-subgroups
Authors: Monakhov Victor S. , Sokhor Irina L.
Published: February 2024

A Schmidt group is a finite non-nilpotent group such that every proper subgroup is nilpotent.
In this paper, we prove that if every Schmidt subgroup of a finite group 𝐺 is subnormal or modular, then

G
/
F

⁢

(
G
)

G/F(G)

is cyclic.
Moreover, for a given prime 𝑝, we describe the structure of finite groups with subnormal or modular Schmidt subgroups of order divisible by 𝑝.
Use of person-centered language in obesity-related publications across sports medicine journals: a systematic review of adherence to person-centered language guidelines in sports medicine
Authors: Webb Jason , Mach Kaylee , Gooch Trey , Reddy Arjun , Anderson Michael , Scott Jeremy , Checketts Jake , Walker Lance , Hartwell Micah
Published: February 2024

Context

Stigmatizing language or non-person-centered language (non-PCL) has been shown to impact patients negatively, especially in the case of obesity. This has led many associations, such as the American Medical Association (AMA) and the International Committee of Medical Journal Editors (ICMJE), to enact guidelines prohibiting the use of stigmatizing language in medical research. In 2018, the AMA adopted person-centered language (PCL) guidelines, including a specific obesity amendment to which all researchers should adhere. However, little research has been conducted to determine if these guidelines are being followed.

Objectives

Our primary objective was to determine if PCL guidelines specific to obesity have been properly followed in the sports medicine journals that are interacted with most frequently.

Methods

We searched within PubMed for obesity-related articles between 2019 and 2022 published in the top 10 most-interacted sports medicine journals based on Google Metrics data. A predetermined list of stigmatizing and non-PCL terms/language was searched within each article.

Results

A total of 198 articles were sampled, of which 58.6 % were found to be not compliant with PCL guidelines. The most common non-PCL terms were “obese” utilized in 49.5 % of articles, followed by “overweight” as the next most common stigmatizing term at 40.4 %. Stigmatizing labels such as “heavy, heavier, heaviness,” “fat” as an adjective, and “morbid” appeared in articles but at a lower rate.

Conclusions

Our study shows that there is a severe lack of adherence to PCL guidelines in the most-interacted sports medicine journals. Negative associations between stigmatizing language and individuals with obesity will only persist if a greater effort is not made to change this. All journals, including the most prestigious ones, should adopt and execute PCL guidelines to prevent the spread of demeaning language in the medical community.
Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
Authors: Chen Lin , Tao Gaofeng , Yang Mei
Published: February 2024

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer and belongs to the category of malignant tumors of the thyroid gland. Autophagy plays an important role in PTC. The purpose of this study is to develop a novel diagnostic model using autophagy-related genes (ARGs) in patients. In this study, RNA sequencing data of PTC samples and normal samples were obtained from GSE33630 and GSE29265. Then, we analyzed GSE33630 datasets and identified 127 DE-ARGs. Functional enrichment analysis suggested that 127 DE-ARGs were mainly enriched in pathways in cancer, protein processing in endoplasmic reticulum, toll-like receptor pathway, MAPK pathway, apoptosis, neurotrophin signaling pathway, and regulation of autophagy. Subsequently, CALCOCO2, DAPK1, and RAC1 among the 127 DE-ARGs were identified as diagnostic genes by support vector machine recursive feature elimination and least absolute shrinkage and selection operator algorithms. Then, we developed a novel diagnostic model using CALCOCO2, DAPK1, and RAC1 and its diagnostic value was confirmed in GSE29265 and our cohorts. Importantly, CALCOCO2 may be a critical regulator involved in immune microenvironment because its expression was related to many types of immune cells. Overall, we developed a novel diagnostic model using CALCOCO2, DAPK1, and RAC1 which can be used as diagnostic markers of PTC.
Linear optical properties of organic microcavity polaritons with non-Markovian quantum state diffusion
Authors: Leppälä Timo , Abdelmagid Ahmed Gaber , Qureshi Hassan A. , Daskalakis Konstantinos S. , Luoma Kimmo
Published: February 2024

Hybridisation of the cavity modes and the excitons to polariton states together with the coupling to the vibrational modes determine the linear optical properties of organic semiconductors in microcavities. In this article we compute the refractive index for such system using the Holstein–Tavis–Cummings model and determine then the linear optical properties using the transfer matrix method. We first extract the parameters for the exciton in our model from fitting to experimentally measured absorption of a 2,7-bis[9,9-di(4-methylphenyl)-fluoren-2-yl]-9,9-di(4-methylphenyl) fluorene (TDAF) molecular thin film. Then we compute the reflectivity of such a thin film in a metal clad microcavity system by including the dispersive microcavity mode to the model. We compute susceptibility of the model systems evolving just a single state vector by using the non-Markovian quantum state diffusion. The computed location and height of the lower and upper polaritons agree with the experiment within the estimated errorbars for small angles

(

≤
30
°

)

$(\le 30{}^{\circ})$

. For larger angles the location of the polariton resonances are within the estimated error.
Observations regarding the synthesis and redox chemistry of heterobimetallic uranyl complexes containing Group 10 metals
Authors: Mikeska Emily R. , Lind Natalie M. , Ervin Alexander C. , Khalife Celine , Karnes Joseph P. , Blakemore James D.
Published: February 2024

Literature reports have demonstrated that Schiff-base-type ligands can serve as robust platforms for the synthesis of heterobimetallic complexes containing transition metals and the uranyl dication (UO2
2+). However, efforts have not advanced to include either synthesis of complexes containing second- or third-row transition metals or measurement of the redox properties of the corresponding heterobimetallic complexes, despite the significance of actinide redox in studies of nuclear fuel reprocessing and separations. Here, metalloligands denoted [Ni], [Pd], and [Pt] that contain the corresponding Group 10 metals have been prepared and a synthetic strategy to access species incorporating the uranyl ion (UO2
2+) has been explored, toward the goal of understanding how the secondary metals could tune uranium-centered redox chemistry. The synthesis and redox characterization of the bimetallic complex [Ni,UO2] was achieved, and factors that appear to govern extension of the chosen synthetic strategy to complexes with Pd and Pt are reported here. Infrared and solid-state structural data from X-ray diffraction analysis of the metalloligands [Pd] and [Pt] show that the metal centers in these complexes adopt the expected square planar geometries, while the structure of the bimetallic [Ni,UO2] reveals that the uranyl moiety influences the coordination environment of Ni(II), including inducement of a puckering of the ligand backbone of the complex in which the phenyl rings fold around the nickel-containing core in an umbrella-shaped fashion. Cyclic voltammetric data collected on the heterobimetallic complexes of both Ni(II) and Pd(II) provide evidence for uranium-centered redox cycling, as well as for the accessibility of other reductions that could be associated with Ni(II) or the organic ligand backbone. Taken together, these results highlight the unique redox behaviors that can be observed in multimetallic systems and design concepts that could be useful for accessing tunable multimetallic complexes containing the uranyl dication.
A new schedule method for compact propulsion system model
Authors: Bai Yu , Zhu Zhengchen , Xu Zhigui , Guo Haoran
Published: February 2024

The PSC (Performance Seeking Control) based on CPSM (Compact Propulsion System Model) has been verified by NASA. However, the CPSM has poor accuracy at off-design points. Therefore, a new basepoint schedule method is proposed to improve the CPSM accuracy at off-design points. At the off-design point, the thermodynamic parameters which is a function of temperature is an importance factor that influence the accuracy of model based on parameter corrections. Therefore, the temperature of fan inlet is taken into account during scheduling the basepoint vector. The simulations have shown that the accuracy of CPSM is at its best when the engine operates at a point where the temperature of the fan inlet is equal to the one of the basepoint. With the increase or decrease of the temperature of the fan inlet, the modeling errors of CPSM will increase. The simulations also demonstrate that the relative errors of the improved CPSM decrease significantly compared to those of the conventional CPSM at the off-design point.
Maximum Strength and Power as Determinants of Match Skating Performance in Elite Youth Ice Hockey Players
Authors: Keiner Michael , Kierot Martin , Stendahl Mattia , Brauner Torsten , Suchomel Timothy J.
Published: February 2024

Keiner, M, Kierot, M, Stendahl, M, Brauner, T, and Suchomel, TJ. Maximum strength and power as determinants of match skating performance in elite youth ice hockey players. J Strength Cond Res XX(X): 000–000, 2023—Maximum strength has a strong influence on speed-strength performances such as sprints and jumps. Important for sports practice is whether these findings are also reflected in game performance. Therefore, the aim of this study was to explore the influence of maximum strength and power performance on linear on-ice skating performance in testing and during game play. A cross-sectional study was conducted, and 24 highly trained male youth ice hockey players participated. Jump performances (countermovement jump [CMJ], drop jumps), maximum strength (1 repetition maximum [1RM] squat and isometric trap bar pull [ITBP]), and on-ice linear sprints (15 m [LS15], 30 m [LS30], flying 15 m [FLY15]) were measured. Match performances (among others: peak skating speed) were collected of 4 regular league games using a local positioning system. Correlation coefficient and explained variance were calculated (ρ ≤ 0.05). Correlations between maximum strength and jump with on-ice linear sprint performance showed 1–35% explained variance. Correlations between “off ice” test (CMJ, relative 1RM) and game data (peak skating speed) showed 22–30% explained variance, respectively, while ITBP and DJ missed significant level. Between linear sprint and game performance showed 15–59% explained variance. In this study, a clear influence of 1RM in squatting and CMJ performance on on-ice linear sprint as well as in-game peak skating speed was observed. These findings show that strength and jumping performance can be valuable tests within a comprehensive test battery and indicate the relevance of strength and jumping tasks within the regular exercise program to improve in-game skating performance.
Investigating the Roles of the Visual and Parietal Cortex in Representing Content versus Context in Visual Working Memory
Authors: Teng Chunyue , Postle Bradley R.
Published: February 2024

Content-to-context binding is crucial for working memory performance. Using a dual-serial retrocueing (DSR) task on oriented gratings, Yu et al. (2020) found that content (orientation) of both prioritized and unprioritized memory items (PMI; UMI) was represented simultaneously in visual cortex, while their context (location) was represented in intraparietal sulcus (IPS), with a priority-based remapping of the representation of content and context of the UMI in each region, respectively. This registered report acquired fMRI of 24 healthy adults while they performed a DSR task with location as the to-be-reported content and orientation as the task-relevant context. We contrasted three accounts: domain-dependent, the engagement of visual and parietal regions depends on the feature domain (orientation vs location); functional, the engagement of these regions depends on their function (content vs context); and hybrid—a combination of the domain-dependent account and the additional stipulation that IPS encodes context regardless of domain. Delay-period activity in early visual cortex conformed most closely with functional predictions: robust priority-sensitive representation of stimulus location (content), but no evidence for the active representation of stimulus orientation (context). Delay-period activity in IPS, in contrast, conformed most closely to predictions of the hybrid account: active representation of content (location) and of prioritized context (orientation). Exploratory analyses further supported the hybrid account of IPS, revealing univariate sensitivity to variation in both content and context load, the latter in a manner that predicted individual differences in behavior. The representation of visual information in working memory is highly dependent on behavioral context.
Poticanje kreativnosti u nastavi
Authors: Pahljina-Reinić Rosanda , Rončević Zubković Barbara , Močibob Iva
Published: February 2024

Rad se bavi načinima osmišljavanja razrednog okružja u funkciji razvoja kreativnih sposobnosti učenika u kontekstu poučavanja za kreativnost. Preduvjeti su razvoja kreativnosti učenika modeliranje kreativnosti nastavnika i poticanje uvjerenja o samodjelotvornosti. Neke od temeljnih tehnika poticanja kreativnosti učenika jesu preispitivanje postojećih pretpostavki, definiranje i redefiniranje problema, poticanje generiranja ideja i poticanje interdisciplinarnog pristupa idejama. Kako bi se izbjegle prepreke kreativnosti, važno je poticati preuzimanje razumnog rizika, omogućavati toleranciju dvosmislenosti/neizvjesnosti i dopuštati pogreške pri učenju. Složene tehnike poticanja kreativnosti učenika usmjerene su razvoju odgovornosti i samoregulacije u kreativnom stvaranju, kao i poučavanju vrijednosti ustrajnog zalaganja i odgode zadovoljstva u kreativnom radu. Kreativni rad zahtijeva uravnoteženost triju misaonih sposobnosti ključnih za uspješnu inteligenciju: analitičkih, kreativnih i praktičnih. Poučavanje prema principima uspješne inteligencije naziva se Trijarhično poučavanje i vrednovanje (Triarchic Instruction and Assessment, TIA) i temelji se na poticanju navedenih sposobnosti. Podrazumijeva učiteljevo pronalaženje materijala najprikladnijih za razvoj određenih sposobnosti (analitičkih, kreativnih i praktičnih) te pomaže učeniku kompenzirati ili ispraviti slabosti, a istaknuti jake strane, čime se pojačava i motivacija za učenje. Na kraju rada prikazani su primjeri provedbe trijarhičnoga poučavanja u nastavi školskog predmeta Hrvatski jezik u petom i šestom razredu, kroz korake planiranja trijarhičnoga poučavanja i vrednovanja.
RISING STARS: Bumps and bacteria: influence of the maternal microbiota on pregnancy outcomes
Authors: Willmott Thomas , Cottrell Elizabeth C
Published: February 2024

During pregnancy, all major physiological systems undergo remarkable changes, driven largely by alterations in the maternal hormonal milieu. In healthy pregnancies, maternal cardiovascular and metabolic adaptation to pregnancy occurs to support fetal growth and maternal well-being. Impaired maternal adaptation to pregnancy is associated with a range of pregnancy complications, including gestational diabetes and preeclampsia. There is growing recognition of the importance of different maternal microbiota, including in the gut, vagina and oral cavity, in supporting normal maternal adaptations to pregnancy as well as evidence for microbial disturbances associating with pregnancy pathologies. Here, we aim to summarise emerging evidence demonstrating that differences in maternal microbiota associate with pregnancy outcomes and discuss potential therapeutic approaches under development that might restore an ‘optimal’ microbiome. In particular, we highlight recent work by ourselves and others exploring the role of the oral microbiome in pregnancy, given established links between poor oral health (e.g. periodontitis) and adverse pregnancy outcomes. Our research has focussed on specific nitrate-reducing oral bacteria which play a role in the generation of nitric oxide (NO) and other bioactive nitrogen oxides associated with cardiovascular health and maternal cardiovascular adaption to pregnancy. Ongoing research aims to define whether altered microbial profiles have clinical utility in the prediction of pregnancy pathologies, and whether interventions designed to optimise specific maternal microbiota could help prevent future complications.
Dependence of Sheet Properties on Formation and Forming Variables
Authors:   Australian Paper Manufacturers Ltd., Research Division, Melbourne, Norman R. J.
Published: February 2024

An investigation of the effect of forming variables on handsheet strength properties showed that stock dilution, shear gradients and controlled initial drainage are factors that have major effects on sheet structure and properties. A better understanding of the causes of changes in paper strength properties resulted from the introduction of a new concept of basic sheet properties. One basic property is the specific tensile strength. This represents the average tensile strength throughout a sheet,in contrast with the standard tensile strength, which is generally a measure of strength in the weakest part of the test samples. The well-known loss of tensile strength that occurs when handsheets are formed from stock at higher concentrations is shown to be caused mainly by small-scale substance variability, since the specific tensile strength is essentially constant over the same range of concentrations. The effect of substance variability on other strength properties was examined by means of uniform base layer sheets with superimposed substance spots. The spots were used to obtain a known and reproducible pattern of substance variability. Notwithstanding the increased substance of the spotted sheets, they were found to be physically weaker in all properties except tearing strength. Substance variability was found also to be responsible for the reciprocal dependence of tearing strength on bursting and tensile strengths. As a test of the practical importance of dilution and shear gradients, Fourdrinier machine trials were run in which the water removal capacity was increased considerably by the application of fan-produced vacuum under the forming zone. Sheet properties were found to be still improving up to the maximum flow box dilution or speed set by other machine limits such as drying and stock pumping.
Structure of Paper in Cross-section
Authors:   British Paper and Board Industry Research Association, Kenley, Surrey, Page D. H. , Sargent J. W. ,   British Paper and Board Industry Research Association, Kenley, Surrey, Nelson R. ,   British Paper and Board Industry Research Association, Kenley, Surrey
Published: February 2024

Previous work on the sectioning of paper has not fully utilised the power of the light microscope. This paper describes techniques developed to enable the structure of paper to be seen in considerable detail in cross-section. The techniques are illustrated by sections of a wide range of types of paper. The consolidation of the structure of paper during manufacture is revealed by micrographs of the effects of beating, pressing, drying with and without restraint, super calendering and creping.
Ultrasonic Impedometric Studies in the Cellulose Pulp/Water System
Authors:   Organic Chemicals Division, Monsanto Co., St Louis, U.S.A., Craver J. K. , Taylor D. L. ,   Organic Chemicals Division, Monsanto Co., St Louis, U.S.A.
Published: February 2024

The high frequency shear mechanical behaviour of cellulose pulp/ watersystems during theprocess of drying from 3 percent solids to total dryness has been non-destructively and continuously monitored by the technique of ultrasonic impedometry. Unusual fibre/water interactions have been detected at both extremes of the concentration range studied. These interactions are given interpretation in molecular terms.
Effect of Drying on the Mechanical Properties of Pulp Fibres
Authors:   Central Laboratory of the Swedish Cellulose Industry (CCL), Stockholm, Duncker B. , Hartler N. ,   Central Laboratory of the Swedish Cellulose Industry (CCL), Stockholm, Samuelsson L. G. ,   Central Laboratory of the Swedish Cellulose Industry (CCL), Stockholm
Published: February 2024

Changes in the axial dimension of chemical pulp fibres were studied, using various combinations of drying and wetting. It was found that the commonly experienced elongation, brought about as a result of wetting, was exchanged for a shrinkage when the applied load before wetting was considerably lower than that applied before the preceding drying. Dimensional stabilisation was found for certain combinations of drying and wetting loads. In addition, fibre stiffness was studied. During drying, the stiffness increased sharply within a dry solids content range of 15-35 percent. Upon further drying, the stiffness of the latewood fibres did not change, whereas that of the earlywood fibres was decreased. The former effect is most likely associated with an increased modulus of elasticity, whereas the latter is probably a result of changes in the fibre cross-section involving collapse.
Thermal Softening, Adhesive Properties and Glass Transitions in Lignin, Hemicellulose and Cellulose
Authors:   Physical Chemistry Division, Pulp and Paper Research Institute of Canada, Montreal, Goring D. A. I.
Published: February 2024

The thermal softening of isolated samples of lignin, hemicellulose and cellulose has been investigated by observation of the thermally induced collapse of a column of powder under constant gravitational load. Softening temperatures of lignins ranged from 127-193°C. Birch xylan and pine glucomannan softened at 167° and 181’C, respectively. Sorption of water by lignin and hemicellulose caused pronounced decrease of the softening temperature-in some cases,to as low as 54°C. Softening points of both dry and moist lignins or hemicelluloses have been shown to correlate with the temperature at which the sample develops adhesive properties. The softening and adhesive behaviour has been explained in terms of the concept of the glass transition for amorphous polymers. Sorbed water is considered to act as a low molecular weight diluent in plasticising the polymer chains and lowering the glass transition temperature. Celluloses were found to soften at temperatures greater than 230°C. In contrast to lignin and hemicellulose, sorption of water by the cellulose had negligible effect on the softening temperature. This difference was probably due to the crystalline nature of cellulose and indicated that water did not plasticise individual cellulose chains at the molecular level.