bluuebunny/crossref_metadata_2025 huggingface dataset:
RARE AND PROTECTED WOODY PLANTS OF THE FRUTICETUM SITE IN THE SOUTH URAL BOTANICAL GARDEN-INSTITUTE (UFA)
Authors: Murzabulatova Fanuza , Polyakova Natal'ya
Published: September 2024

The collection fund of almost all botanical gardens in Russia and other countries contains a collection of rare and protected plants, which is a gene pool and a base for the reintroduction of endangered and conservation of rare species. The purpose of research is to determine the degree of resistance of some rare and protected woody plants from various climatic zones in the conditions of the Republic of Bashkortostan. Research was conducted over 19 years. The objects of research are 24 species of rare and protected woody plants of the Fruticetum section of the South Ural Botanical Garden-Institute (Ufa), which have different levels of protection status. Winter hardiness was determined according to the Main Botanical Garden scale, seed germination – according to standard methods. Introduction studies of 24 rare and protected plants were carried out, 7 of which are listed in the Red Data Book of the Russian Federation (Corylus colurna, Deutzia glabrata, Exochorda serratifolia, Hydrangea petiolaris, Prinsepia sinensis, Pterocarya pterocarpa, Sorbocotoneaster pozdnjakovii), and the rest are listed in regional Red Books. It has been established that almost all protected species are in good health, bloom and bear fruit annually, can reproduce by seed and vegetative means, and have high winter hardiness. The only exceptions are a few species, the resistance of which we have defined as conditional. For example, Aralia elata blooms, bears fruit, and sets full-fledged seeds annually, but annual shoots of this species often freeze. Lespedeza bicolor has been defined by us as a species that is unstable in culture due to late flowering and damage to flowers by early frosts, as a result of which this species has no seeds; in addition, annual shoots of this species often freeze. Securinega suffruticosa, according to our data, is also conditionally resistant due to reduced winter hardiness, although it blooms, bears fruit, and produces viable seeds annually. Thus, according to the research results, 18 species out of 24 have high resistance in culture in the conditions of the Bashkir Cis-Urals.
INFLUENCE OF SOME FACTORS ON STUD BULLS REPRODUCTIVE CAPACITY IN KRASNOYARSK REGION
Authors: Chetvertakova Elena , Mirvaliev Firuz
Published: September 2024

The aim of the study is to investigate the reproductive capacity of stud bulls of AO Kras-noyarskagroplem. Objectives: to analyze sperm production indicators taking into account the breed, linear affiliation and ecogenesis of bulls; the ability of bull sperm to deep freezing; fertilizing ability and calving results of cows. The object of the study were stud bulls of AO Krasnoyarskagroplem of the red-and-white (n = 4) and Holstein (n = 11) breeds in the period 2014–2019, having different ecogenesis. The material was the sperm production of the stud bulls. The sperm indicators were assessed in accordance with GOSTs. The fertilizing ability and calving results of cows on farms in the Krasnoyarsk Region were carried out using the IAS SELEKS – Dairy Cattle. Breeding accounting in farms. On average, Holstein bulls produced 38.4% more ejaculates per year (P > 0.95), but their ejaculate volume was 12.5 % less than that of red-and-white bulls. The Holstein bull Kompas 9080 had a low sperm concentration of 0.97 billion/ml, with an average activity of 79 % and a native semen rejection rate of 9.7 %. The largest amount of native semen was rejected from the bulls Tiger 9189 and Ural 20751 – 26.9 and 22.6 %, respectively. The red-and-white bull Volan 17436 also had a low sperm concentration of 1.08 billion/ml. The highest ejaculate volume was produced by the bull Polet 28345 – 5.46 ml. Bulls born in the Krasnoyarsk Region produced 7.5 % (P > 0.99) more ejaculate volume than bulls born in the Netherlands. Spermatozoa obtained from Holstein bulls tolerated deep cooling worse, since after defrosting 9.9 % (P > 0.95) of sperm doses were rejected due to poor survival. The proportion of cows fruitfully inseminated from the first insemination averaged 72 %. Stillborn calves were most often born from the bull Radon 11764 of the V.B. Ideal line and the bull Variant 21682 of the S.T. Rokit line.
MONITORING OF BARLEY STONEFLY PATHOGEN IN THE CONDITIONS OF THE FOREST-STEPPE OF THE PRIOBIE REGION
Authors: Behtol'd Nina , Orlova Elena
Published: September 2024

The aim of research is to study the racial composition of the population of the causative agent of the di-sease Ustilago hordei in the forest-steppe conditions of the Priobie Region. The studies were conducted in 2009–2023 in field conditions against the infectious background of the phytopathological section of the plant gene pool laboratory SibRIPP&B – Branch of IC&G SB RAS, Novosibirsk District, Novosibirsk Region. The objects of study were seven differentiating varieties of the generally accepted Russian set (Excelsior, Himalaya, Hannchen, Lion, Nepal, Pannier, Trebi). The experiments were placed on fallow. Sowing was carried out in the first ten days of May. The accounting reaction of each variety was recorded by the maximum damage. Diseased and healthy ears were counted in the phase of full grain maturity. The degree of plant resistance was determined according to the scale of V.I. Krivchenko, where R is resistant varieties (damage up to 10 %), S is susceptible varieties (damage more than 10 %). Analysis of experimental data showed that the Novosibirsk population of U. hordei in 2009, 2010 and 2014 was represented by race 7, in 2011 and 2013 race 3 predominated in the population of the causative agent of hard smut, and in 2012 – race 2. In 2015, the racial composition changed and race 12 appeared in the population. Since 2016, the population has not been differentiated into races; the Excelsior and Hannchen varieties carrying the Ruh 2 and Ruh 1 genes have shown a susceptible reaction (for eight years). The highly resistant Himalaya variety-differentiator shows a type of reaction that does not correspond to the known key for determining races. The Pannier variety has shown stable resistance to the stone smut pathogen over all years of observation.
PECULIARITIES OF WATER REGIME AND EVALUATION OF HEAT RESISTANCE OF USSURI PEAR UNDER BIOFERTILIZER USE
Authors: Fedorova Dar'ya , Galaktionova Lyudmila
Published: September 2024

The aim of the study is to determine the indicators of drought resistance and heat resistance of Ussuri pear growing in a semiarid climate using biofertilizers (using the city of Orenburg as an example). Drought resistance of plants is one of the important factors for the successful cultivation of new taxa in climatic conditions in the presence of limiting factors. Excessive high temperature causes rapid cell damage or death, which leads to catastrophic changes in the entire plant organism. The use of certain types of fertilizers can increase the resistance of cultivated plants to various types of stress, including exposure to high temperatures. Heat resistance, total water content, water deficit, water-holding capacity and the level of mobile moisture in leaf blades were determined using generally accepted methods in laboratory conditions. For this purpose, the leaves were weighed: freshly picked, after 24 hours, after complete saturation, absolutely dry. The resistance of the samples to high temperatures was assessed using a water bath. It was established that the experimental plants, with the introduction of the studied fertilizer, significantly increase their heat resistance and they belong to the group of highly heat-resistant plants. The degree of drought resistance is also higher in experimental samples, compared to the control. Having assessed the degree of water regime using a modified technique for the climate of the Orenburg Region, the authors conclude that the experimental samples belong to the group of plants with high drought resistance, the control ones - to the group of moderately drought-resistant plants.
Advances and challenges in gene therapy for dystrophic epidermolysis bullosa: Insights from therapeutic strategies and animal models
Authors: Wang Xianqing , Ward Josie , He Wei , Wang Wenxin , Li Ming
Published: September 2024

Dystrophic epidermolysis bullosa (DEB) is a severe monogenic skin disorder resulting from mutations in the COL7A1 gene, which disrupts the synthesis of type VII collagen. This leads to impaired anchoring fibrils and results in dermoepidermal separation. The clinical manifestation of DEB varies significantly, ranging from localized blistering in milder forms to extensive blistering with subsequent severe complications such as vision loss and squamous cell carcinoma in more severe cases. Despite the recent approval of the first gene replacement therapy by the U.S. Food and Drug Administration, the majority of DEB patients still depend on palliative care, an indication of the continued unmet therapeutic needs. In the past two decades, there has been a rapid advancement of gene therapy techniques, extensive research efforts, and pre-clinical studies focusing on the correction of DNA, RNA, and protein defects specific to DEB. In this review, we provide a comprehensive update on the current state of gene engineering strategies for DEB, including gene replacement, pre-mRNA regulatory therapies, and gene editing techniques. In addition, this review critically evaluates the role and development of animal models in DEB research, which are crucial for the progression of therapeutic strategies. Our discussion aims to delineate the existing challenges and emphasize ongoing advancements in the gene therapy landscape for DEB, providing insights that may guide future research and clinical approaches.
Deformation monitoring and stress distribution prediction of 3D-printed hydroxyapatite scaffolds
Authors: Yao Danyu , Zhang Luge , Liu Hong , Liu Ming , Wang Ling , Xu Mingen
Published: September 2024

Hydroxyapatite (HAP) scaffolds created through biological three-dimensional (3D) printing have been extensively utilized in bone tissue engineering. However, clinical outcomes remain unsatisfactory. Stress-induced fractures are a primary cause of failure in clinical bone implant repairs. Finite element analysis (FEA) can predict stress distribution within scaffolds under load, aiding in the identification of stress concentrations. Nevertheless, limitations in the printing fidelity of bio-inks lead to discrepancies between the printed scaffold structure and the theoretical design, resulting in inaccurate predictions. This study introduced an effective approach for predicting the mechanical properties and internal stress distribution of printed scaffolds. HAP scaffolds with varying filling angles (90º, 60º, 45º) were constructed through 3D printing. These scaffolds were analyzed using a combination of optical coherence tomography (P-OCT) scanning and micro-computed tomography (micro-CT) imaging, integrated with FEA, to enhance the accuracy of stress distribution predictions. The findings demonstrated that the mechanical strength of scaffolds predicted by the reconstructed model was closer to experimental values compared to predictions made by commonly used theoretical models (improved from 55% to 78%). During actual testing, stress concentration sites predicted by the reconstructed model were the first to exhibit fragmentation, validating the accuracy of stress distribution predictions. Moreover, scaffolds printed at different infill angles displayed varying degrees of distortion. Scaffolds printed at a 90º angle showed the highest fidelity with the fewest defects, and their stress distributions under different conditions were well-correlated.  The method proposed in this study facilitates more accurate prediction and evaluation of scaffold performance early in development, enabling the selection of scaffolds with suitable mechanical properties, thereby reducing testing cycles and improving safety in bone defect repair.
 
The Rise of Bot-Driven Fraud: Understanding Threats and Implementing Advanced Prevention Strategies
Authors: - Jeffrie Joshua Lazarus George
Published: September 2024

In today’s digital landscape, the proliferation of bots has fundamentally changed the cybersecurity ecosystem. While bots were initially designed to automate simple, repetitive tasks, they have since evolved into sophisticated tools used by cybercriminals to carry out large-scale attacks. From brute force attacks and credential stuffing to account takeovers and denial of service (DoS) attacks, bots pose a growing threat to businesses across all sectors. The damage caused by bot-driven fraud extends far beyond financial losses—it affects operational efficiency, customer trust, and brand reputation. This paper explores the various types of bot-driven fraud, the consequences businesses face as a result of these activities, and the advanced prevention strategies that are being developed to counter these threats. By understanding how bots are used in cybercrime and implementing proactive defense mechanisms, businesses can reduce their vulnerability to fraud and better protect their customers and assets.
New Provisions for Police Officers in BNSS
Authors: - Shubham Shukla
Published: September 2024

On July 1, 2024, three historic criminal laws—the Bharatiya Nyaya Sanhita (BNS), Bharatiya Nagarik Suraksha Sanhita (BNSS), and Bharatiya Sakshya Adhinayam (BSA)—replaced three antiquated statutes from the British colonial era in India. The new laws aim to improve India's criminal justice system and offer a more effective framework for dealing with criminal activity. The main points of the BNS, which aims to replace the Indian Penal Code (IPC), which was created a century ago, will be covered in this article. The BNS worsens the retributive system by introducing wide and imprecisely defined offenses, upholding crimes with roots in outmoded moral principles, and continuing the growth of state and police authority. It is argued that the main goal of the legislation's drafting appears to be to provide the impression that colonial legacies—that is, obsolete colonial laws—have been abandoned, all the while advancing a nationalist agenda meant to instill a sense of patriotism in the general populace.
Laplace-Stieltjes Transform and its Asymptotic Expansion
Authors: - M K Nikam
Published: September 2024

In this paper we will present the Laplace-Stieltjes transform and its asymptotic expansion.Asymptotic Transforms which comes to further improvement the extension of the Laplace-Stieltjes Transforms to all locally integrable function as proposed by Watson's Lemma. It gives us a way to obtain the complete asymptotic expansion of integrals on the real axis that have an exponential type of kernel.. To obtain the asymptotic expansion of the transform, we follow the technique of Handelsman and Blestein.
A Study on Flood Hazard Zonation Mapping Based on GIS-driven Approach using Remote Sensing Data and Weighted Overlay Analysis (Woa) Model
Authors: - Kamuju.narasayya
Published: September 2024

Flood hazard mapping is crucial for identifying flood-prone areas and developing effective mitigation strategies. This study utilized a Weighted Overlay Analysis, which is one of the subjective model derived from Multi-Criteria Decision Support System (MCDA), to assess flood hazards in the Auranga watershed, India. Six key flood-inducing factors were selected, including topographic data such as elevation, slope, river distance, and flow length derived from remote sensing data of Digital Elevation Model and classified Land use/Land cover data, along with hydro-meteorological data of precipitation. Each dataset was standardized to a common scale to facilitate comparison and integration. Weights were assigned to the layers like elevation, slope, river distance, flow length, Land use/Land cover, and precipitation according to their significance in contributing to flood risk. These weighted layers were then combined using GIS tools like ArcGIS, resulting in a composite map that delineates areas with varying flood hazard zones. The final flood hazard map identified that approximately 914 sq. km (60.0%) of the study area was at high to very high flood risk, particularly in regions close to rivers, while around 97 sq. km (6.4%) exhibited very low flood hazard. The GIS-Weighted Overlay Analysis method proved effective in flood hazard zone mapping, especially when incorporating a greater number of parameters. This approach is widely recognized in environmental planning and risk assessment, especially in areas vulnerable to natural disasters like floods.
Harnessing AI for Early Detection of Cardiovascular Diseases: Insights from Predictive Models Using Patient Data
Authors: - Ali Husnain , - Ayesha Saeed , - Ahad Hussain , - Ahsan Ahmad , - Mahnoor N. Gondal
Published: September 2024

Cardiovascular diseases (CVDs) continue to be the leading cause of death in the world, taking millions of lives every year. Early detection and treatment of these diseases are critical in preventing deaths and illnesses. Currently, traditional diagnostic methods like routine clinical examinations and other standard risk assessment tools fail to detect CVDs in early on set stages, posing numerous limitations for preventable interventions. This work explores incorporating artificial intelligence (AI) to catalyze early CVD diagnosis using AI models for patient data including electrocardiogram (ECG), wearable-generated metrics, and medical history.
The research showcased the ability of AI to predict with high accuracy when CVD would start using machine learning methods such as Random Forest, Support Vector Machines (SVM) and Neural Networks. The powerful AI models were carefully constructed by training and testing them on an extensive dataset that contained measurements of diverse patient characteristics including many other readouts related to cardiovascular risk. Compared to traditional methods, the models outperformed, and Neural Networks had an accuracy of 92% in identifying high-risk patients. A hallmark of this work is that AI identifies subtle patterns and relationships within patient data ones that conventional approaches might not find.
These AI-based predictive models might soon become part of the routine clinical evaluation for cardiovascular disease, providing a personalized and early health intervention to empower your cardiovascular care. Timely identification of these high-risk patients could allow for targeted interventions, leading to improved health and reductions in healthcare spending. Despite the promising potential that AI holds in healthcare, it also has brought up issues of data privacy, ethical use and the need for extensive clinical validation.
This paper suggests a predictive strategy could be implemented using AI algorithms to lead early detection and management of CVD, which opens an opportunity for individualized care accompanied by big data era. Future studies should focus on improving such models with more diverse and larger datasets as well as overcoming logistical difficulties encountered in integrating AI into clinical workflows.
Insomnia: Why is it Common?
Authors: - Puneetinder Kaur
Published: September 2024

Insomnia is a disorder where a person suffers from the lack of sleep or finds himself in the position of restlessness. It’s a paradox of constant unrest in deportment and puts mass variations in well-being causing mental health issues and downcast in health conditions. Lately, the cases of insomnia have increased worldwide and there has been noted a specific increase in number of adolescents facing it. Nevertheless, every problem has a solution and same is right to say in case of insomnia. Relaxation Techniques, exercises, avoiding caffeine, consulting therapist etc, are some renowned ways for curing insomnia.
Industrial SMB chromatography as an alternative to the conventional refining of raw cane sugar
Authors: Arrieta Irma , Gaudet Cy , Haskell Cade , Peacock Steve , Tzschätzsch Oliver , Schulze Bernd-Christoph
Published: September 2024

Simulated moving bed (SMB) chromatography is a well-established and widespread unit operation in the beet sugar industry and has been practiced commercially for more than thirty years. SMB chromatography has proven to be very efficient at removing inorganic ash components and colorants from sugar liquors, particularly those colorants with relatively high molecular masses. Recent optimization of the separation using raw sugar with a color ranging from 2000 IU up to 4000 IU has focused on minimizing the capital and operating costs of a chromatography system to replace the various purification and decolorization steps in conventional raw cane sugar refining. Decolorization levels exceeding 89% have been reliably achieved in the extract fraction from chromatography, along with ash removals ranging from 92% to 97%. As only water is added to purify the sugar, the application of this technology, in combination with modern industrial heat pumps and mechanical vapor recompression, allows for a powerful CO2-neutral process, with all the associated benefits regarding permits and marketability. The potential of this technology includes integration into new refinery projects (either standalone or back-end) by replacing affination, carbonatation and ion exchange decolorization (with raw sugar colors of up to 5000 IU), to expansion of existing refinery sites for slip stream processing of raw sugar syrups or refinery run-off syrups after clarification, and to the introduction of new process steps, such as direct liquid sugar production from cane raw sugar.
Sanatsal Etkinliklerin Süreğen Hastalığı Olan Çocuklar ve Onların Bakımını Üstlenen Yakınları Üzerindeki Etkileri
Authors: Altaş Sedat , Aydeniz Arif , Aydeniz Mustafa Barış
Published: September 2024

Bu çalışma, Antalya ilinde süreğen hastalığa sahip çocuklar ve onlara bakım veren yakınlarına yönelik olarak yürütülmüştür. Araştırmada süreğen hastalığı olan çocukların ve bu hastalara birinci dereceden bakım veren aile bireylerinin, hastalığın yapısından kaynaklanan sıkıntıları incelenmiş ve bu bireylere hastalık sırasında karşılaştıkları güçlüklerle baş etme konusunda destek olunması amaçlanmıştır. Çalışma Antalya ilinde; Konyaaltı, Muratpaşa ve Kepez ilçelerinde yaşayan, çeşitli yaş gruplarında yer alan ve süreğen hastalığı olan 11’i erkek 14’ü kız olmak üzere 10-12 yaş aralığında toplam 25 süreğen hastalığa sahip çocuk ve bu çocuklara birinci dereceden bakım veren yakınları ile gerçekleştirilmiştir. Çalışmada süreğen hastalar ve hasta yakınlarının seçilme nedeni bu alana yönelik yapılmış sınırlı sayıda araştırma olması ve bu hastalığa sahip bireylere yönelik sanata dayalı bir yol izleyen herhangi bir çalışmaya rastlanmamış olmasıdır. Etkinlikler öncesinde hasta ve hasta yakınlarına yönelik yarı yapılandırılmış görüşme formları uygulanmış ardından 6 hafta boyunca resim, müzik ve edebiyat etkinliklerinden oluşan sanatsal program uygulanmıştır. Etkinlikler sonrasında programın etkili olup olmadığının anlaşılması için programa katılanlarla tekrar görüşmeler yapılmıştır. Çalışma sonucunda; süreğen hastalığa sahip çocuklara yönelik yapılacak sanatsal etkinliklerin; çocukları daha mutlu, daha değerli, daha umutlu, daha güçlü ve daha huzurlu hissettirdiğini, çocukların hastalığa karşı daha dirençli olabildiklerini ortaya koyması bakımından önem arz etmektedir. Ayrıca hasta yakınlarının da yoğun olarak hissettiği; tükenmişlik, öfke, umutsuzluk, mutsuzluk, yalnızlık, desteklenmeme, özlem, kendini suçlama gibi olumsuz duyguların; mutluluk, umut, şükür, sabır, güçlülük gibi duygulara dönüştüğünü göstermesi açısından da değerlidir. Bu bakımdan sonuçlar, çalışmanın amacına uygun şekilde tutarlılık göstermiştir. Süreğen hastalar ve hastalara bakım veren aile üyelerine yönelik çalışmalarda, sanatsal etkinliklerin etkili olabileceği anlaşılmıştır.
IMMERSIVE INTERVIEW OF MYKOLA TYMOSHYK AS A RESPONSE TO MODERN CHALLENGES
Authors: Halych Valentyna , Halych Artem
Published: September 2024

The need to study the genre of the modern interview is motivated by such factors as the active transformation of the system of journalistic genres under the influence of world trends of the era of globalization and the latest information technologies and socio-political changes in the young Ukrainian state, marked by the cultivation of the principles of democracy; the weak development of the theory of the interview genre due to its active penetration into the content and structure of informational and analytical genres and the generation of numerous modification and diffusion forms; the activity of interviews in the Ukrainian printed and electronic mass media during the war. In addition, the research through the prism of traditions and innovation of the works of this genre of dialogic speech in the journalistic output of Mykola Tymoshyk, an outstanding scientist, public figure and teacher, gives an opportunity to emphasize other problems of the modern interview, in particular, moral-ethical, axiological, educational.
The object of the study is the immersive (virtual) interview of Mykola Tymoshyk under the heading «Olha Kobylianska about the lack of spirituality and mancurtism of Ukrainians», and its subject is the specificity of the genre of interview with a monument and its communicative and educational potential. The purpose and task of the article consist in revealing the immersive content of the interview with the monument in the informational challenges of the modern time as a representative of the portrait of Mykola Tymoshyk. The interview in his creative output has not yet become the object of a systematic and comprehensive study. Our publication is a first attempt to fill this lacuna. The methods of scientific research (discursive, biographical, historical, axiological, typological) helped to reveal the subject of scientific research in various aspects, in particular, to present the interview of Mykola Tymoshyk as a multidimensional communicative phenomenon in the coordinates of social time and space, to comment on its content taking into account spiritual values and in tangibility to the scientific, educational and public activities of the author.
The result of the study is the definition of an immersive interview as a type of journalistic work of a dialogic form, which contributes to the immersion of recipients in virtual/augmented reality, a kind of unreal, artificially created world, with which they can interact in real time in order to understand actual current problems.
Key words: journalistic activity, journalism, genre, immersive interview, convergence, modification, portraiting.
Mechanical Properties of Macaca fascicularis Amniotic Membrane and Duramater: A Potential Biomaterial for Dural Defect Closure
Authors: Ban Bolly Hendrikus Masang , Rachmawati Noverina  , Ahmad Faried
Published: September 2024

Background: The amniotic membrane (AM), a versatile biomaterial with inherent stem cells and extracellular matrix, has shown promise in various tissue engineering applications. Its potential as a dural substitute, particularly in addressing dural defects and preventing cerebrospinal fluid (CSF) leakage, has garnered increasing interest. However, a comprehensive understanding of the mechanical properties of non-human primate (NHP) AM, especially in relation to human AM, remains elusive. This knowledge gap hinders the optimal utilization of NHP models, such as Macaca fascicularis, in translational research for dural repair. This study aimed to characterize the mechanical properties of fresh Macaca fascicularis AM and dura mater and to investigate the influence of fetal gender, gestational age, and parity on AM mechanics.
Methods: Sixteen fresh preparation amniotic membranes of Macaca fascicularis were obtained at the elective caesarean section that was already free of several infections, and three fresh preparation of dura mater of the same species were studied. The membranes were cut in specific sizes and then loaded at the Flavigraph (Textechno, Herbert Stein GmbH & Co.KG, Moenchengladbach, Germany) machine. The Young’s modulus, ultimate tensile strength, elongation at break, maximum elongation, and toughness of the amniotic membrane and dura mater were recorded and compared based on the fetal gender, gestational ages, and frequency of pregnancy.
Results: This is the first report of mechanical properties of Macaca fascicularis amniotic membrane and dura mater. There are no statistically significant differences in mechanical properties of the amniotic membrane between the fetal gender, gestational age, and the frequency of pregnancy in fresh preparation amniotic membrane. The elasticity of the dura mater is seven times stiffer than the AM and the tensile strength of the dura mater is three times bigger than the AM, and the dura mater toughness is eight times bigger than the amniotic membrane.
Conclusion: Our findings have shown the mechanical properties of Mf AM are not dependent on factors of fetal gender, gestational age, and frequency of pregnancy. This work provides an explanation of the physical properties of fresh preparation AM as the consideration to be used as allograft biomaterial in the dura mater substitution procedure.
Long COVID and gut candidiasis: What is the existing relationship?
Authors: Bistagnino Filippo , Pizzi Davide , Mantovani Filippo , Antonino Jacopo Rosso , Tovani-Palone Marcos Roberto
Published: September 2024

Since the beginning of the coronavirus disease (COVID) 2019 pandemic, thousands of articles on the topic have been published, and although there is a growing trend of research on another associated condition, long coronavirus disease, important points still remain to be clarified in this respect. Robust evidence has suggested a relevant link between new clinical discoveries and molecular mechanisms that could be associated with the manifestations of different signs and symptoms involving cases of long COVID. However, one of the existing gaps that requires further investigation concerns a possible relationship between gut candidiasis and long COVID. While recent studies also suggest an interplay between the occurrence of these two conditions, it is not yet fully clear how this may happen, as well as the specifics regarding the possible pathophysiological mechanisms involved. In this connection and with the advent of a potential strengthening of the body of evidence supporting the hypothesis of a link between gut candidiasis and long COVID, a better understanding of the clinical presentation, pathophysiology and clinical management of such a relationship should be essential and useful for both, additional advances towards more targeted research and appropriate case management. Knowing more about the signs, symptoms, and complications associated with cases of long COVID is essential in order to more effectively mitigate the related burden and provide a higher quality of care and life for the affected population. In light of this and the need for better outcomes, here we review and discuss the content on different aspects of long COVID, including its pathophysiology and the existing evidence of a potential relationship between such a condition and gut candidiasis, as well as suggest propositions for future related research.
FAKTOR-FAKTOR YANG MEMPENGARUHI PENGGUNAAN ROKOK ELEKTRIK (VAPE) PADA MAHASISWA INSTITUT TEKNOLOGI DAN BISNIS INDRAGIRI
Authors: Monifa Putri  , Fitriyani Bahriyah
Published: September 2024

Cigarettes are common and a health problem in the world. The habit of smoking is like a culture in Indonesia. Not only parents, teenagers and children also have smoking behavior and habits. In Indonesia, conventional cigarettes are no stranger to society, now a new trend has emerged, namely the use of electric cigarettes or vapes. Therefore it is necessary to know the factors that influence the use of electric cigarettes (vape) among students of the Indragiri Institute of Technology and Business. The research method used is analytic with a cross sectional approach. The results showed that out of 96 students, 9,4% used electric cigarettes (vape). The results of the chi square test for family environmental factors obtained a p value of 0.00, p value of 0.00 for lifestyle factors and p value of 0.00 for social environmental factors. The conclusion from this study is that there is an influence between family environmental factors, lifestyle and social environment with the use of electric cigarettes (vape) in students of the Indragiri Institute of Technology and Business.
ASUHAN KEBIDANAN PADA REMAJA NN P PENGKONSUMSIAN TELUR TERHADAP PENDERITA ANEMIA PADA REMAJA PUTRI DI PUSKESMAS TG BALAI KARIMUN
Authors: Nilma  , Arum Dwi Anjani  , Dian Juni Eka Sari
Published: September 2024

The vulnerability of young women to anemia occurs due to increased iron needs, excessive menstrual bleeding and lack of balanced nutritional intake (Rati & Jawadagi, 2014). Efforts to increase the hemoglobin level of pregnant women apart from giving Fe tablets, can also be combined with complementary therapies, one of which is by consuming eggs. Objective To provide comprehensive and continuous midwifery care for adolescents, with management of midwifery care in accordance with midwifery service standards. Midwifery care that is applied is the provision of chicken eggs to increase Hb levels in adolescents. Method The type of research used in the preparation of the practice report was a descriptive study conducted at the Tanjung Balai Karimun Health Center in January 2023. Results Evaluation of the care provided related to anemia showed that consumption of chicken eggs helped increase Hb levels in the blood in adolescents. Conclusion SOAP data on midwifery care related to Midwifery Care for Adolescents by implementing the consumption of Dark Chocolate in adolescent midwifery care to relieve menstrual pain
PROJETO DE MODELO CONCEITUAL PARA INVESTIDORES DO TIPO CORPORATE VENTURE CAPITALIST
Authors: Verillo Felipe , Queiroz Jayme , Carbonell Lívia , Carrard Emília Colonese
Published: September 2024

Esse trabalho introduz e contextualiza os processos realizados pela Gerência de Investimentos (GEINV) da Agência Brasileira de Promoção de Exportações e Investimentos (ApexBrasil) com o objetivo de propor um aprimoramento no registro e organização de dados para gerar inteligência. Para tanto, revisita esforço já realizado pela GEINV para organizar e segmentar clientes, analisa o sistema atual para cadastro de clientes, elabora mapas conceituais e constrói propostas de aprimoramento para o cadastro de um perfil específico de cliente da ApexBrasil, o Corporate Venture Capitalist. Como próximos passos, sugere parceria com outras áreas da Agência para implantação das mudanças propostas, bem como ampliação do esforço para os demais perfis de clientes da GEINV.
SEGMENTAÇÃO DE CARTEIRA DE CLIENTES COM BASE NO CADASTRO NACIONAL DE EMPRESAS EXPORTADORAS BRASILEIRAS
Authors: Bonecker Renata M. M. , Moreira Cesar A. C. , Paula Dayane E.C. , Verri Filipe A. N.
Published: September 2024

Este estudo realiza a identificação do perfil das empresas brasileiras exportadoras, a partir da lista de exportadoras e importadoras divulgada pelo governo brasileiro, dados fornecidos pela SECEX-MDIC (Secretaria de Comércio Exterior do Ministério do Desenvolvimento, Indústria, Comércio e Serviços) e pela Receita Federal do Brasil. Realizada a análise exploratória dos dados, técnicas de análise de componentes principais, de agrupamento (k-médias) e de mineração de regras de associação foram aplicadas. Por meio da análise de componentes principais, considerando dez atributos quantitativos, foi possível identificar uma quantidade de grupos para iniciar o agrupamento via k-médias. Por conseguinte, por meio de k-médias, foi possível validar a quantidade de grupos e analisar as características de cada grupo para os atributos quantitativos selecionados. E, por fim, com a utilização da técnica de mineração de regras de associação, foi possível extrair características interpretáveis de apenas um grupo. Como resultado, há evidências que os dados existentes não são adequados para identificar o perfil das empresas e que, portanto, para atingir o objetivo será necessário enriquecer a base com informações, tais como valor exportado pela empresa, produto exportado e quantidade de países para os quais a empresa exportou, entre outras.
NEUROPATIA DIABÉTICA AUTONÔMICA CARDIOVASCULAR: UMA REVISÃO ATUALIZADA
Authors: França Marcelle Mariana Sales , Santos Yasmim Barbosa , Silva Maria Vanessa , Nascimento Bruno José , Alves Érique Ricardo , Pereira Alef de Moura , Santos Anthony Marcos Gomes , Medina Vanessa Bischoff , Teixeira Álvaro Aguiar Coelho , Teixeira Valéria Wanderley
Published: September 2024

O Diabetes Mellitus (DM) é uma doença caracterizada pela hiperglicemia crônica, os tipos mais comuns são diabetes tipo 1 (DM1) e diabetes tipo 2 (DM2). Esta doença causa outras enfermidades, em que as mais comuns são a retinopatia, nefropatia e a neuropatia, que afeta 50% dos indivíduos acometidos com a DM. A mesma causa lesão nervosa, diminuição da função nervosa, perfusão sanguínea e nervos desnutridos. Dentre os tipos de neuropatia diabética, existem as difusas e focais. Dentre as difusas, há a Neuropatia Diabética Autonômica Cardiovascular (NDAC) que surge devido a reações em cascata que refletem no comprometimento do coração, influenciando no desequilíbrio do sistema simpático e parassimpático. O objetivo deste trabalho foi elaborar uma revisão bibliográfica sobre a neuropatia diabética autonômica cardiovascular e seus aspectos gerais com base em estudos mais recentes. Para isso, foi realizada uma busca no período entre os meses de janeiro e junho de 2024, em bancos de dados como PubMed, Scielo, ScienseDirect e Scopus. Tendo como critério artigos entre os anos de 2020 até 2024. Foi encontrado na literatura como a doença se desenvolve e um padrão ouro de diagnóstico. Porém, apesar de haver vários estudos em busca das melhores estratégias para sua prevenção e tratamento, ainda não há um padrão médico para o seu manejo.
DEVELOPMENT OF A WEBSITE TO ADVERTISE JOB VACANCIES FOR DISABLED PEOPLE
Authors: Oliveira F. P. , Heemann N. F. , Bennemann C. B. , Faria J. G. , Fiirst W. G. , Souza S. S. F. , Lima F. P. A.
Published: September 2024

This work proposes the development of a website to advertise job openings for people with disabilities. The justification is based on the high number of people with disabilities in Brazil, who have some special needs, and who have the right to work. It also aims to help companies comply with the law through a tool to advertise job openings. Developing a website is a current and innovative solution, since today more than 80% of the population has access to the internet and smartphones. And it is an interaction and access technology that can be successfully applied to help the community solve a problem. Although work is essential in the life of a person with disabilities, companies claim that they have great difficulty in placing these professionals on their staff. The main difficulty exposed by employers is the lack of professional training of people with disabilities, and also the lack of interest in filling the vacancies. The Brazilian Institute for the Rights of People with Disabilities (IBDD) says that the big problem is that companies do not advertise vacancies for people with disabilities. Therefore, the objective of this work refers to the development of a website, designed, modeled and developed using HTML, CSS and Javascript, to assist in the process of advertising job vacancies for the disabled.
TRATAMENTO FARMACOLÓGICO DE ESCOLHA COM ISOTRETINOÍNA PARA ACNE NÓDULA-CÍSTICA E CONGLOBATA EVIDENCIANDO A EFICIÊNCIA DO TRATAMENTO E OS ALERTAS PARA OS EFEITOS ADVERSOS.: BREVE REVISÃO DA LITERATURA
Authors: CONCEIÇÃO Kamyla Gabrielly Souza , ROLA Marcela Gomes , DEUNER Melissa Cardoso , DA SILVA Ilan Iginio , OYARZÚN Katherinne Patricia Saraiva Iginio , SOUSA Darlete da Silva , DA COSTA Priscilla Mota , DE SOUZA Karoline Brizola , DA SILVA Ariadne Gisele , MENDES João Marcos Torres do Nascimento , DE OLIVEIRA Gregório Otto Bento
Published: September 2024

A acne, uma inflamação crônica da pele, tradicionalmente tratada com antimicrobianos, retinóides e agentes abrasivos, viu suas perspectivas transformadas com o advento da isotretinoína oral. Este estudo bibliográfico visa analisar a eficácia e tolerabilidade da isotretinoína no tratamento da acne, avaliando seus benefícios e impacto na qualidade de vida dos pacientes. Metodologia: Foram selecionados 5 artigos publicados entre 2010 e 2022, após análise de 20 estudos relevantes. A revisão crítica da literatura permitiu a comparação de métodos, resultados e conclusões, construindo um panorama abrangente sobre o tema. Resultados e Discussão: A isotretinoína demonstrou alta efetividade no tratamento da acne, com melhora significativa em mais de 80% dos casos. As principais reações adversas observadas foram mucocutâneas, como queilite, xerodermia, ressecamento das mucosas e diminuição do fluxo salivar. Tais efeitos, geralmente leves a moderados, são reversíveis e desaparecem após o término do tratamento. Considerações Finais: A isotretinoína se configura como uma terapia eficaz e segura para a acne, com potencial para melhorar consideravelmente a qualidade de vida dos pacientes. O farmacêutico, como profissional de saúde, assume um papel crucial na orientação sobre os riscos teratogênicos, posologia, possíveis reações e interações medicamentosas, garantindo um tratamento individualizado e eficaz.
AVALIAÇÃO DAS CONDIÇÕES HIGIÊNICO-SANITÁRIAS NA COMERCIALIZAÇÃO DE PESCADOS NO MUNICÍPIO DE RAPOSA – MA
Authors: Diniz Celivânia de Araújo , Silva Ladilson Rodrigues , Oliveira Nayara Silva , Moraes Poliana Santos , Moraes Ana Paula Santos , Vitor Juliana Sá , Ribeiro Diego Luiz dos Santos , Ribeiro Larissa Sarmento dos Santos
Published: September 2024

Objetivo: Avaliar as condições higiênico-sanitárias e de infraestrutura do local de comercialização de pescado no município de Raposa–MA. Metodologia: Foi realizada uma vistoria no porto, principal ponto de comercialização de pescados do município, com o intuito de observar as principais deficiências na infraestrutura. A avaliação das condições higiênico-sanitárias do local foi realizada por meio da aplicação de um checklist, elaborado com base na RDC n° 216/2004 da ANVISA, que incluiu seis parâmetros avaliados (instalações físicas, equipamentos e utensílios, manipuladores, ambiente, matéria-prima e o gelo). Resultados: Com base na análise dos dados obtidos por meio do checklist, observou-se que o porto apresentava um percentual de 83% de atributos não conformes, de acordo com RDC n° 216 /2004 da ANVISA. Com relação às instalações físicas do local, foi possível observar que o local não possui estrutura adequada para o funcionamento, apresentando somente bancas improvisadas com guarda-sol. O piso possuía falhas em algumas áreas, o que possibilita a infiltração e o acúmulo de água que são produzidas pelo derretimento do gelo. O local não possuía rede de esgoto e a água utilizada durante a comercialização dos pescados fica exposta a céu aberto. Foi observado que os manipuladores não utilizavam equipamentos de proteção individual (EPI’S), tais como: máscaras de proteção, uniformes, aventais, calçados fechados, toucas e luvas. Quanto aos equipamentos e utensílios que são utilizados na manipulação dos alimentos, foi possível observar que as caixas térmicas utilizadas para o acondicionamento do pescado estavam sujas e malconservadas, bem como as balanças, facas, tábuas de corte se apresentavam sujas. O método de conservação utilizado pelos comerciantes de pescado é através do gelo em escama, porém foi observado que não estava acondicionando o pescado de forma adequada em grande parte das caixas analisadas.. Conclusão: Há necessidade de melhorias na estrutura física do local, além da implementação de boas práticas de manipulação de alimentos, que pode ser realizada através da conscientização tanto dos vendedores quanto da população, garantindo assim a integridade dos produtos comercializados no município de Raposa–MA.
RESISTÊNCIA INSULÍNICA HEPÁTICA DIABETES TIPO 2 HEPÁTICO: DIABETES TIPO 2 HEPÁTICO
Authors: Andrade LJO , Oliveira GCM , Bittencourt AMV , Xavier IP , Oliveira LM
Published: September 2024

Introdução: O fígado desempenha um papel crucial na homeostase da glicose e dos lipídios. A resistência à insulina (RI) tem sido cada vez mais reconhecida como um fator etiológico primário em distúrbios metabólicos. A resistência à insulina hepática (RIH) é uma manifestação específica da RI, caracterizada pela redução da resposta do fígado à insulina, apesar dos níveis elevados de insulina circulante. Objetivo: Esta revisão visa elucidar o papel da RIH na patogênese de distúrbios metabólicos, focando em sua relação com a doença hepática gordurosa não alcoólica (DHEADM) e o diabetes mellitus tipo 2 (DM2). Métodos: Foi realizada uma pesquisa bibliográfica abrangente para explorar os mecanismos subjacentes da RIH, suas implicações clínicas e sua associação com a DHEADM e o DM2. Resultados: A RIH é caracterizada pela captação prejudicada da glicose mediada pela insulina e pelo aumento da produção de glicose hepática. Essa disfunção metabólica contribui para o desenvolvimento de esteatose hepática, dislipidemia e resistência à insulina nos tecidos periféricos. A interação entre RIH e lipogênese é importante na progressão da DHEADM e sua associação com o DM2, podendo ser descrita como um equivalente hepático do DM2. Conclusão: A compreensão de uma condição semelhante ao DM2 no fígado é decisiva para o desenvolvimento de tratamentos mais direcionados e eficazes.
ANÁLISE DA SOBREVIDA DE PACIENTES SUBMETIDOS A TRANSPLANTE ALOGÊNICO DE CÉLULAS PROGENITORAS HEMATOPOÉTICAS NA PRÉ E NA PANDEMIA DE COVID-19 EM UM HOSPITAL DO RIO DE JANEIRO
Authors: Vieira PFC , Lobato JCP , Morais CCPL , Galvani RG , Pereira MVA , Souza AM
Published: September 2024

Introdução: A pandemia de covid-19 alterou a dinâmica de conservação dos enxertos e de realização dos transplantes de células progenitoras hematopoiéticas (TCPH) alogênicos o que pode ter afetado a sobrevida dos pacientes. Objetivo: Analisar a sobrevida dos pacientes pós-TCPH imediato (100 dias pós-TCPH) segundo exposição aos diferentes tipos de transplantes e fontes de enxerto, na pré-pandemia e na pandemia de covid-19. Método: Estudo de coorte retrospectiva retrospectivo de base hospitalar com 246 pacientes que realizaram TCPH em hospital de referência no município do Rio de Janeiro entre janeiro/2016 e dezembro/2021. Os métodos de log rank e Kaplan Meier foram utilizados para estimar as funções de sobrevida de pós-TCPH imediato. Resultados: A taxa de mortalidade foi ligeiramente superior na pandemia quando comparada à pré-pandemia (10,1% vs. 8,8%). O enxerto mais utilizado em todo o período estudado foi medula óssea (MO, com 85%). Porém, na pandemia, 50,5% das coletas alogênicas foram realizadas utilizando o sangue periférico mobilizado (SPM). Oito por cento dos enxertos criopreservados não foram infundidos. Não foram observadas diferenças na sobrevida entre pacientes que utilizaram SPM como fonte de enxerto em relação à MO. Conclusão: Os tipos de enxerto e as fontes de transplantes não influenciaram a sobrevida dos pacientes em ambos os períodos. A criopreservação se apresentou como uma ferramenta importante para superar os desafios logísticos ligados à pandemia de covid-19, porém, um percentual relevante de enxertos criopreservados não foram utilizados. Assim, é necessário que os centros transplantadores voltem a realizar TCPH com produtos frescos, reduzindo o percentual de inutilização dos enxertos.