bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Variational Autoencoders for Imputing Missing Values from Sensor Data of Marine Systems
Authors: Velasco-Gallego Christian , Lazakis Iraklis
Published: September 2022

Of all the causes of accidents to ships, 14% pertains to damage due to ship equipment. Accordingly, the maritime industry is currently considering state-of-the-art maintenance and inspection processes, an example of which is condition-based maintenance (CBM). This is a strategy that hinges on the condition monitoring (CM) of assets. CM has proven to increase efficiency, reliability, profitability, and performance of vessel. To enable this maintenance strategy, sensors need to be installed along the most critical ship components and around the environment where these assets are operating through the application of Internet of Ships (IoS). IoS has demonstrated to be effective for collecting data in real time as well as performing diagnosis and prognosis to assess the current and future health of machinery to assist instant decision-making. The employment of IoS presents several challenges, an example of which is the imputation of missing values. Data imputation is a compelling preprocessing step, the aim of this is to estimate identified missing values to avoid underutilization of data. This data preparation step has gained popularity over the last few years due to its importance when dealing with Industrial Internet of Things (IIoT) sensor data. Although some articles presented new methodologies to impute missing values from sensor data of marine machinery based on machine learning methodologies, deep learning models have not yet been considered. For this reason, variational autoencoders for imputing missing values from sensor data of marine systems are analyzed in this article. To assess the performance of variational autoencoders as imputation methods, a comparative study is performed with widely implemented imputation techniques. Mean imputation, Forward Fill and Backward Fill, and k-Nearest Neighbors are considered. To that end, a case study on marine machinery system parameters obtained from sensors installed on a diesel generator of a tanker ship is performed. Results demonstrate the applicability of variational autoencoders when dealing with missing values of marine machinery systems sensor data, achieving a coefficient of determination of 0.99 when imputing missing values of the diesel generator power parameter.
Management of Adverse Events in Early Clinical Trials by Advanced Practice Providers in the Outpatient Setting: The University of Texas MD Anderson Cancer Center Experience
Authors: D. Barber, PhD, ANP-BC, AOCNP, FAANP, FAAN Fedricker , Campbell, MS Erick , Yamamura, BA Yuko , J. Patterson, DNP, MPH, WHNP, ANP Clover , C. Hartnett, MSN, NP-C Audrey , Kinahan, MSN, ANP-C, AOCNP Holly , A. Miller, MSN, FNP-BC Victoria , L. Brink, DNP, FNP-BC, AOCNP Amanda , Poullard, DNP, ACNP-BC Anna , E. Urshel, DNP, FNP-BC Gabriele , Brantley, MSN, AGNP-C Andre , G. Cepeda, MSN, AGNP-C Isabel , Goswami, DNP, FNP-C, AOCNP Poonam , Charles, MSN, FNP-BC Sheena , Philip, MSN, FNP Shincy , Bresser, MPAS, PA-C Sara , Musekiwa-Adjei, MSN, FNP-C Sandra , Perez, MSN, FNP-C Nageli , Le, PhD Hung , Phillips, RN, MSN, MBA Penny , Subbiah, MD Vivek , Meric-Bernstam, MD Funda , E. Dumbrava, MD Ecaterina
Published: September 2022

Background: Advanced practice providers (APPs) play important roles in enrolling, educating, and caring for patients in clinical trials. However, much remains unknown about the role of APPs in managing adverse events (AEs) in early (phase I to II) clinical trials. In this study, we assessed the outpatient management of grade 3 to 4 AEs by APPs in early trials and characterized the workflow of our APP Phase I to II Fast Track (FT) Clinic. Patients and Methods: We retrospectively reviewed records of patients with advanced or metastatic solid tumors enrolled in phase I to II clinical trials who were seen by APPs from September 2017 to August 2018 in the APP phase I to II FT clinic in the Department of Investigational Cancer Therapeutics. Results: A total of 808 patients enrolled in 159 clinical trials were seen in 2,697 visits (median 3 visits per patient; range 1–28) by 10 APPs. Treatment was interrupted in 6.9% of visits, and grade 3 to 4 AEs were seen in 5.4% of visits; however, patients from 1.4% of visits were sent to the emergency center (EC) and/or admitted. Patients referred to the EC and/or admitted were more likely to have baseline hypoalbuminemia, high lactate dehydrogenase, and poor Eastern Cooperative Oncology Group performance status (i.e., ECOG > 1; p < .001). There were no associations between EC referral and gender, APP years of experience, or type of treatment. Conclusions: The APP Phase I to II FT Clinic has an important role in the management of AEs by APPs in early clinical trials in the outpatient setting, potentially avoiding EC visits and admissions.
Ultrasound Evaluation of Carotid Artery Intima-Media Thickness: Effective Early Marker of Carotid Artery Disease in Adult Head and Neck Cancer Patients After Neck Radiation?
Authors: Randolph, APRN Whitney , E. Dains, DrPH, JD, APRN, FNP-BC, FNAP, FAANP Joyce
Published: September 2022

Radiation is a recommended front-line treatment for many adult head and neck cancer (HNC) patients. Early identification of radiation-associated carotid artery disease (CAD), a well-known phenomenon, can minimize long-term sequelae. This integrative literature review assesses the use of ultrasound measured carotid artery intima-media thickness (IMT) as an early marker of CAD in adult HNC patients after neck radiation. A search of PubMed and Scopus databases in December 2020 yielded 475 unique articles published between January 2011 and December 2020, of which eight met inclusion criteria. Carotid IMT, measured by ultrasound, was significantly increased after neck radiation in all reviewed publications. Ultrasound was able to detect IMT measurements exceeding or at risk of exceeding pathologic IMT, indicating higher risk for future cardiovascular events. Findings suggest that radiation-associated carotid IMT increase occurs early and persists for years. Ultrasound adequately detects post-radiation carotid IMT changes and is a reliable early marker for radiation-associated CAD. Initiation of ultrasound screening should be considered prior to neck radiation for a baseline and at 1 year post treatment to optimize medical management.
Gavin D’Costa and Faydra L. Shapiro, Eds. Contemporary Catholic Approaches to the People, Land and State of Israel
Authors: Frizzell Lawrence E.
Published: September 2022

No abstract is available.
LA PERCEPCIÓN MUSICAL: UN ESTUDIO CON ESTUDIANTES UNIVERSITARIOS DE ESPAÑA Y PORTUGAL
Authors: Olcina-Sempere Gustau , Reis-Jorge José , Ferreira Marco
Published: September 2022

El presente artículo se ha realizado con estudiantes universitarios que estaban realizando el Grado de Maestro de Educación Primaria en España y Portugal durante el curso 2018-2019. El objetivo principal es conocer hasta qué punto la visualización de la interpretación musical transmite emociones diferentes de las transmitidas solo al escucharla. Diversos estudios han demostrado que la percepción de las emociones provocadas por la escucha de la música está en gran medida influenciada por la interpretación de los músicos. En este estudio, se utilizó un cuestionario compuesto por preguntas cerradas para recopilar los datos. Participaron 125 estudiantes de sus respectivas instituciones de educación superior tanto en Portugal como en España. Los resultados obtenidos corroboran, en general, las representaciones teóricas y los resultados empíricos presentados en la literatura previa. Los participantes muestran que la visualización de una obra musical genera diferentes emociones generadas por la interpretación del músico, es decir, que los rasgos interpretativos de cada intérprete son de vital importancia para la transmisión de las distintas emociones.
La investigación en Educación Musical en Chile: tensiones y desafíos en el siglo XXI
Authors: Chiuminatto orrego Marcello gonzalo
Published: September 2022

El presente trabajo tiene como objetivo dar cuenta de las tensiones y desafíos a los que se enfrenta la investigación en Educación Musical en Chile de cara al siglo XXI. Las actuales formas de construcción de la música en términos expresivos y conceptuales, así como las abruptas transformaciones vinculadas con la irrupción de las nuevas tecnologías, generan un complejo y extenso ámbito de investigación. Dichos estudios, deben ser abordados de forma crítica e integral con la intención de (re)establecer y (re)formular la importancia de la Educación Musical en el contexto de la cultura chilena actual. A través de un estudio documental exploratorio, se aborda el desplazamiento que está sufriendo la disciplina musical en los distintos niveles educativos, así como los graves problemas de empleabilidad que afectan al sector. También se analizan cuestiones de género y se exponen algunos elementos de decolonización en el ámbito de la música. Además, se analiza el complejo escenario que ha afectado y tensionado de forma directa a la educación musical chilena a causa del estallido social y la pandemia. Se concluye que las temáticas de investigación se deben fundar en la comprensión y desarrollo del pensamiento crítico en y desde la Educación Musical.
EL CONOCIMIENTO Y EL USO DEL SINTETIZADOR EN LA EDUCACIÓN MUSICAL DE CATALUÑA: UN ANÁLISIS A TRAVÉS DE ENTREVISTAS A PERSONAS EXPERTAS
Authors: Puentes Madarnás Pablo , González-Martín Cristina , Ponsatí Ferrer Imma
Published: September 2022

Resumen. En la actualidad existe una amplia variedad de estilos musicales que incluyen el sintetizador en su proceso de creación. El uso de este instrumento en la industria musical se ha extendido de tal modo que consideramos necesario llevar a cabo una investigación exploratoria para examinar cómo esto se reflejaba en las aulas de educación musical. El objetivo de la investigación, pues, se centró en indagar acerca del conocimiento y el uso del sintetizador en los diversos niveles de la educación musical de Cataluña. Para ello, se realizaron entrevistas semiestructuradas a 8 expertos en tecnología y educación musical. La información fue analizada mediante la técnica del análisis temático y los resultados obtenidos revelaron que: (1) las experiencias con el sintetizador en la educación musical son escasas; (2) los motivos por los que el sintetizador no se usa regularmente en la educación musical son variados, destacando la falta de formación del profesorado, la falta de tiempo en los currículos y la falta de materiales didácticos; (3) las propuestas de los expertos para la didáctica del sintetizador muestran puntos de acuerdo y discrepancias, y (4) las opiniones de los expertos muestran la importancia de una miscelánea de temas en torno al contexto educativo actual, el autodidactismo, y las TIC y la música. A partir de este análisis, podemos concluir que (1) es preciso formar al profesorado en cuanto al conocimiento y uso del sintetizador en el aula, (2) es necesario poner al alcance del profesorado materiales didácticos y orientaciones metodológicas para facilitar su implementación en el aula, y (3) el uso apropiado del sintetizador puede dar al alumnado la oportunidad de experimentar con sonidos que le son familiares, contribuyendo a que el timbre reciba en la educación musical la misma atención de la que disfruta en la industria musical.
AN ADDITIVE MANUFACTURING AND LATTICE STRUCTURES PERSPECTIVE FOCUSED ON BIOMIMETIC KNEE IMPLANT DESIGN
Authors: GONZALEZ NAVARRETE ROBERTO , VIDAL LESSO AGUSTIN , PLASCENCIA MORA HECTOR , REVELES ARREDONDO JUAN FRANCISCO
Published: September 2022

There are different types of knee implants, each seeking to restore the natural behavior of a healthy knee. Factors such as contact stress, wear and fatigue have been extensively analyzed for their design.
Work Environment: Leadership, Communication, and Autonomy. The Perception of Work Among Polish Employees During Turbulent Time of COVID-19 Pandemic
Authors:   Cracow University of Economics, Sady Monika , Sedlak Piotr ,   Cracow University of Economics
Published: September 2022

Purpose: The article focuses on the assessment of knowledge workers’ relation with superiors, internal communication, perceived autonomy and feeling of appreciation. The goal of the article is also to extend current knowledge of the perception of cooperation between employees. The authors were able to identify interdependencies among the researched variables and the impact of COVID-19 on peoples’ professional situation. Design/methodology/approach: The article presents the results of a CAWI survey conducted on a large sample of 2778 specialists and managers in Poland. The researchers used the purposive sampling method to reach the population of white-collar workers who experienced remote work or remote cooperation with their colleagues. Findings: The empirical study showed that in most cases superiors passed the test and were positively evaluated by their subordinates. The correlation analysis also showed that certain positive qualities of a manager go together and are positively correlated with professional situation assessment during the COVID-19 period. Research limitations/implications: The study describes the results in a large sample; however, the sampling method was not probabilistic and therefore we cannot use statistical inference for the general population of working specialists in Poland. Originality/value: The value of the article is the presentation of the up-to-date opinion of almost 3 thousands specialists employed in Poland. The text plays an important role in recording the influence of the pandemic on Polish employees.
Information Asymmetry, Capital Structure and Equity Value of Firms Listed on the WSE
Authors:   University of Warsaw, Gralewska Milena , Białek-Jaworska Anna
Published: September 2022

The paper investigates the impact of capital structure and information asymmetry on the value of companies listed on the Warsaw Stock Exchange. The study was conducted using the ordinary least squares (OLS) method on a sample of 273 companies in 2017 and the GMM dynamic paneldata approach with instrumental variables. Data retrieved from the Notoria, Bloomberg and Orbis databases were used. The results show that despite its impact on reducing the cost of capital, increasing debt does not lead to an increase in equity value. Therefore, the benefi ts of higher short-term leverage are limited and visible only for long-term debt. On the other hand, despite bigger information asymmetry, companies are valued higher, which means that asymmetrical information does not necessarily hurt valuation in the short term but in the long term. The results contribute to the literature on firms’ use of leverage under information asymmetry, showing higher trust in cash flow than profits in books.
Knowledge of Network-Based Market Orientation for the Internationalization of Disruptive Innovation in SMEs
Authors:   University of Gävle, Hyder Akmal , Sundström Agneta ,   University of Gävle, Chowdhury Ehsanul ,   University of Gävle
Published: September 2022

Purpose: This study explores the knowledge development of network-based market orientation (MO) for the internationalization of disruptive innovation (DI) by small and medium-sized enterprises (SMEs). Methodology: To manage knowledge development for DI internationalization, a business model was applied to a case study of an individual example. The studied company participated in a series of workshops and allowed on-site visits and interviews for two years in a European Union-funded project. The workshops helped the company to gather MO and networking knowledge and then apply that knowledge internally in the organization and externally, in interactions with suppliers, buyers, and other members of the buyer chain. Findings: Although technological and market efforts usually proceed separately, this study shows that technical and MO knowledge can go together through external and internal networking. Research limitations/implications: To overcome the limitation of having just one example in a case study, several SMEs can be included in future research to produce a comparative analysis. A further study can investigate how technical and market networks can be integrated in the knowledge development process to speed up internationalization. Managers can learn to internationalize DI by collaborating, knowledge sharing, and networking with other SMEs, suppliers, and firms in the buyer chain. Originality: The current study contributes to DI literature by highlighting knowledge generation in SMEs from a process perspective as well as by integrating technical and MO efforts for internationalization.
RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification
Authors: Hutchins Erica J , Gandhi Shashank , Chacon Jose , Piacentino Michael , Bronner Marianne E
Published: September 2022

While neural crest development is known to be transcriptionally controlled via sequential activation of gene regulatory networks (GRNs), recent evidence increasingly implicates a role for post-transcriptional regulation in modulating the output of these regulatory circuits. Using available single-cell RNA-sequencing datasets from avian embryos to identify potential post-transcriptional regulators, we found that Elavl1, which encodes for an RNA-binding protein with roles in transcript stability, was enriched in the premigratory cranial neural crest. Perturbation of Elavl1 resulted in premature neural crest delamination from the neural tube as well as significant reduction in transcripts associated with the neural crest specification GRN, phenotypes that are also observed with downregulation of the canonical Wnt inhibitor Draxin. That Draxin is the primary target for stabilization by Elavl1 during cranial neural crest specification was shown by RNA-sequencing, RNA immunoprecipitation, RNA decay measurement, and proximity ligation assays, further supporting the idea that the downregulation of neural crest specifier expression upon Elavl1 knockdown was largely due to loss of Draxin. Importantly, exogenous Draxin rescued cranial neural crest specification defects observed with Elavl1 knockdown. Thus, Elavl1 plays a critical a role in the maintenance of cranial neural crest specification via Draxin mRNA stabilization. Together, these data highlight an important intersection of post-transcriptional regulation with modulation of the neural crest specification GRN.
Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands
Authors: Gao Zhiyao , Zheng Li , Krieger-Redwood Katya , Halai Ajay , Margulies Daniel S , Smallwood Jonathan , Jefferies Elizabeth
Published: September 2022

Understanding how thought emerges from the topographical structure of the cerebral cortex is a primary goal of cognitive neuroscience. Recent work has revealed a principal gradient of intrinsic connectivity capturing the separation of sensory-motor cortex from transmodal regions of the default mode network (DMN); this is thought to facilitate memory-guided cognition. However, studies have not explored how this dimension of connectivity changes when conceptual retrieval is controlled to suit the context. We used gradient decomposition of informational connectivity in a semantic association task to establish how the similarity in connectivity across brain regions changes during familiar and more original patterns of retrieval. Multivoxel activation patterns at opposite ends of the principal gradient were more divergent when participants retrieved stronger associations; therefore, when long-term semantic information is sufficient for ongoing cognition, regions supporting heteromodal memory are functionally separated from sensory-motor experience. In contrast, when less related concepts were linked, this dimension of connectivity was reduced in strength as semantic control regions separated from the DMN to generate more flexible and original responses. We also observed fewer dimensions within the neural response towards the apex of the principal gradient when strong associations were retrieved, reflecting less complex or varied neural coding across trials and participants. In this way, the principal gradient explains how semantic cognition is organised in the human cerebral cortex: the separation of DMN from sensory-motor systems is a hallmark of the retrieval of strong conceptual links that are culturally shared.
The SPARC complex defines RNAPII promoters in Trypanosoma brucei
Authors: Staneva Desislava P , Bresson Stefan , Auchynnikava Tatsiana , Spanos Christos , Rappsilber Juri , Jeyaprakash A Arockia , Tollervey David , Matthews Keith R , Allshire Robin C
Published: September 2022

Kinetoplastids are a highly divergent lineage of eukaryotes with unusual mechanisms for regulating gene expression. We previously surveyed 65 putative chromatin factors in the kinetoplastid Trypanosoma brucei. Our analyses revealed that the predicted histone methyltransferase SET27 and the Chromodomain protein CRD1 are tightly concentrated at RNAPII transcription start regions (TSRs). Here, we report that SET27 and CRD1, together with four previously uncharacterized constituents, form the SET27 promoter-associated regulatory complex (SPARC), which is specifically enriched at TSRs. SET27 loss leads to aberrant RNAPII recruitment to promoter sites, accumulation of polyadenylated transcripts upstream of normal transcription start sites, and conversion of some normally unidirectional promoters to bidirectional promoters. Transcriptome analysis in the absence of SET27 revealed upregulated mRNA expression in the vicinity of SPARC peaks within the main body of chromosomes in addition to derepression of genes encoding variant surface glycoproteins (VSGs) located in subtelomeric regions. These analyses uncover a novel chromatin-associated complex required to establish accurate promoter position and directionality.
Distributed search and fusion for wine label image retrieval
Authors: Li Xiaoqing , Ma Jinwen
Published: September 2022

With the popularity of wine culture and the development of artificial intelligence (AI) technology, wine label image retrieval becomes more and more important. Taking an wine label image as an input, the goal of this task is to return the wine information that the user hopes to know, such as the main brand and sub-brand of the wine. The main challenge in wine label image retrieval task is that there are a large number of wine brands with the imbalance of their sample images which strongly affects the training of the retrieval system based on deep learning. To solve this problem, this article adopts a distribted strategy and proposes two distributed retrieval frameworks. It is demonstrated by the experimental results on the large scale wine label dataset and the Oxford flowers dataset that both our proposed distributed retrieval frameworks are effective and even greatly outperform the previous state-of-the-art retrieval models.
Evaluation of knowledge and barriers of influenza vaccine uptake among university students in Saudi Arabia; a cross-sectional analysis
Authors: Mallhi Tauqeer Hussain , Bokharee Nida , Bukhsh Munnaza , Khan Yusra Habib , Alzarea Abdulaziz Ibrahim , Khan Faiz Ullah , Khan Salah-Ud-Din , Alotaibi Nasser Hadal , Alanazi Abdullah Salah , Butt Muhammad Hammad , Alatawi Ahmed D. , Iqbal Muhammad Shahid
Published: September 2022

Background

Influenza vaccine hesitancy is a significant threat to global maneuvers for reducing the burden of seasonal and pandemic influenza. This study estimated the vaccine uptake, barriers, and willingness for influenza vaccines among university students in Saudi Arabia.

Methods

A cross-sectional survey was conducted among health science (HS) and non-health science (NHS) university students. A 31-item questionnaire was used to ascertain the vaccination rate, barriers, and willingness for the flu vaccine.

Results

This study included 790 students (mean age: 21.40 ± 1.94 years), 246 (31.1%) from HS and 544 (68.9%) from NHS disciplines. About 70% did not take flu shots before the arrival of the winter. The mean knowledge score was 7.81 ± 1.96, where 20.4%, 67.6%, and 12% of respondents had good, moderate, and poor knowledge regarding flu vaccines. The relative importance index (RII) analysis showed a lack of recommendation from physicians (51.5%, RI ranked: 1) was a top-ranked barrier to vaccine uptake, followed by negative perceptions and accessibility issues. Only 36.6% of the participants were willing to get vaccinated every year, 70% were willing to receive a vaccine on their doctor’s recommendations, and 46% agreed to vaccinate if vaccines were freely available in the university. The knowledge, barriers, and willingness widely varied across students from two disciplines.

Conclusions

Our analysis underscored low flu vaccine uptake among university students. In addition, the study participants’ knowledge was unsatisfactory, and they were less inclined to receive the flu vaccine in the future. Lack of recommendation from the physicians, negative perceptions towards the flu vaccine, and difficult accessibility were found as significant barriers to the vaccine uptake. A multidimensional approach at educational institutes to cover the knowledge gap and address the barriers curtailing the vaccination rate among students is recommended.
The effect of high and low velocity-based training on the throwing performance of collegiate handball players
Authors: Abuajwa Bassam , Hamlin Mike , Hafiz Eliza , Razman Rizal
Published: September 2022

Background

The intensity of strength training exercise is generally regarded to be the most essential element in developing muscle strength and power. The exercise intensity of strength training is known as one-repetition maximum (1RM). Velocity-based training (VBT) has been proposed as a different approach for determining training intensity. VBT relies on the use of linear position transducers and inertial measurement units, providing real-time feedback to objectively adjust the exercise intensity based on an athlete’s velocity zone.

Methods

This study investigated the effects of two different training interventions based on individualized load velocity profiles (LVP) on maximal bench press strength (i.e., 1RM), maximum throwing velocity (TV), and skeletal muscle mass (SKMM). Twenty-two university handball players were randomly assigned to Group 1 (low-movement speed training) or Group 2 (high-movement speed training). Group 1 exercised with a bar speed of 0.75–0.96 m/s, which corresponds to a resistance of approximately 60% 1RM, whereas Group 2 trained at 1.03–1.20 m/s, corresponding to a resistance of approximately 40% 1RM. Both groups exercised three times a week for five weeks, with strength and throwing tests performed at baseline and post-intervention.

Results

A two-way repeated measures ANOVA was applied, and the results showed the interaction between group and time was not statistically significant for SKMM (p = 0.537), 1RM (p = 0.883), or TV (p = 0.774). However, both groups significantly improved after the five weeks of training: SKMM (3.1% and 3.5%, p < 0.01), 1RM (15.5% and 15.0%, p < 0.01), and throwing velocity (18.7% and 18.3%, p < 0.01) in Group 1 and 2 respectively. Training at both prescribed velocities in this study elicited similar changes in strength, muscle mass, and throwing velocity.
Cold water and harmful algal blooms linked to coral reef collapse in the Eastern Tropical Pacific
Authors: Palmer Caroline , Jimenez Carlos , Bassey Giovanni , Ruiz Eleazar , Villalobos Cubero Tatiana , Chavarria Diaz Maria Marta , Harrison Xavier A. , Puschendorf Robert
Published: September 2022

Background

With conventional coral reef conservation methods proving ineffective against intensifying climate change, efforts have focussed on augmenting coral tolerance to warmer water—the primary driver of coral declines. We document coral cover and composition in relation to sea surface temperature (SST) over 25-years, of six marginal reefs in an upwelling area of Costa Rica’s Eastern Tropical Pacific.

Methods

Using reef survey data and sea surface temperature (SST) dating back over 25-years, we document coral cover and composition of six marginal reefs in an upwelling area of Costa Rica’s Eastern Tropical Pacific in relation to thermal highs and lows.

Results.

A ubiquitous and catastrophic coral die-off event occurred in 2009, driven by SST minima and likely by the presence of extreme harmful algal blooms. Coral cover was dramatically reduced and coral composition shifted from dominant branching Pocillopora to massive Pavona, Porites, and Gardineroseris. The lack of coral recovery in the decade since indicates a breach in ecosystem tipping-point and highlights a need for resilience-based management (RBM) and restoration. We propose a locally tailored and globally scalable approach to coral reef declines that is founded in RBM and informed by coral health dynamics.
Pablo Neruda y el opio (del pueblo). La “metafísica cubierta de amapolas” de Residencia en la Tierra
Authors:   Colorado State University (Estados Unidos), Leal Francisco
Published: September 2022

Residencia en la tierra es la obra más experimental de Pablo Neruda (1904-1973). La crítica que se ha volcado sobre este libro reitera que los años del poeta en Asia (1927-32) son detonantes de ese libro. En sus años en Asia, Neruda coniesa haber fumado muchas pipas de opio y escribió sobre esas experiencias. Este trabajo investiga las maneras en que el opio en Neruda trasluce una posible inspiración narcótica de Residencia en la tierra, deteniéndose en la manera en que la crítica nerudiana ha negado activamente la droga como inspiración y cómo el opio presenta otra versión de Neruda (no amorosa ni política) y las maneras en que el poeta utiliza al opio como signo que marca signiicativas divisiones en su poética
Los colores de las palabras y su sombra: acerca de la poesía de Manuel Silva Acevedo
Authors:   Pontificia Universidad Católica de Chile (Chile), Zaldívar Ovalle María Inés
Published: September 2022

Sin Resumen
Comparison of Uric Acid Levels in Hypertensive Patients with and without Heart Disease: A Case-control Study
Authors: Prathyusha Prathivadi Bhayankara , Pullaiah A , Kumari V Ratna
Published: September 2022

Introduction: Hypertensive heart disease is the 13th leading cause of death worldwide. Uric Acid (UA) is an end product of purine metabolism in humans and higher serum UA is a potential independent risk factor for Cardiovascular Disease. Aim: To compare the levels of serum UA in hypertensive individuals with and without cardiovascular disease. Materials and Methods: This case-control study was done at RIMS, Telangana, India from October to December 2021 including 50 individuals with hypertension and without cardiovascular disease enrolled as controls and 100 individuals with Hypertensive Heart Disease (HHD) as cases. The HHD cases were subdivided into group 2A (age <=55 years) and 2B (age >55 years). Samples were collected and analysed for UA, lipid profile, serum creatinine, fasting blood sugar, etc. Independent samples T-test was used for statistical analysis using Statistical Package for Social Sciences (SPSS) software version 28.0.1.1 (15). Results: Males and females were taken in a ratio of 1:1. Mean age for control group was 54.6±9.6 years, for HHD ≤55 years was 50±3.232 and for HHD >55 years was 63.26±6.137 years. In males, mean values of serum UA was 5.1±0.5 mg/dL in controls, 9.2±1.0 mg/dL in HHD ≤55 years (p-value=0.03), 6.4±0.8 mg/ dL in HHD >55 years (p-value=0.1). In females, mean values of serum UA was 4.8±0.4 mg/dL in controls, 10.5±0.4 mg/dL in HHD ≤55 years (p-value=0.009), 6.9±0.5 mg/dL in HHD >55 years (p-value=0.09) Standard Deviation (SD). Serum UA levels were significantly higher in patients of HHD less than 55 years of age than that of controls. Conclusion: Based upon the findings of the study, it was concluded that hypertensive individuals with cardiac disease had higher levels of serum UA than controls, especially in females.
Evaluation of Pregnancy Outcome in Women with First Trimester Vaginal Bleeding: A Longitudinal Study at a Tertiary Care Hospital, Kolkata, India
Authors: Naskar Animesh , Chowdhury Rupsha , Saha Pradip Kumar , Das Rup Kamal
Published: September 2022

Introduction: First trimester vaginal bleeding, a serious obstetric challenge to developing embryo, occurs in 15-25% of all pregnant women. It is a matter of great concern to both mother and obstetrician for its increased association of adverse maternal and foetal outcome. Aim: To measure the prevalence of patients with first trimester vaginal bleeding, to evaluate factors associated with it and to assess foeto-maternal outcome in those pregnant women. Materials and Methods: This was a prospective, hospitalbased, longitudinal study carried out among 120 women with first trimester vaginal bleeding having normal bodyweight, and regular cycles and agreeing to follow-up, at Department of Obstetrics and Gynaecology in a tertiary teaching hospital, Kolkata, West Bengal, India, from January 2019 to June 2020. The incidence of vaginal bleeding in first trimester, its risk factors, foeto-maternal outcome in terms of Pregnancy Induced Hypertension (PIH), abortions, preterm deliveries, Antepartum Haemorrhages (APH), birth weight of baby, low APGAR (Appearance or colour of the baby, Pulse, Grimace, Activity, and Respiration) score at birth were assessed. The descriptive statistics to calculate percentage and mean and Chi-square-test with significance value considered at p-value <0.05. Results: Out of 4716 pregnant women attending in Obstetric clinic at their first trimester, 332 had vaginal bleeding, incidence being 7.04%. Out of 332 women, 120 study participants met inclusion criteria. Of 120 cases, 79 (65.8%) were from age group of 21-30 years. Highest incidence was 74 (61.7%) in primigravida. Incidence was high in poor socio-economic status (upper lower and lower) ie., 57 and unplanned cases, 87 (72.5%). On followup of 120 participants, 66 (55%) had threatened abortion, of them 51.5% (34/66) led to term pregnancy followed by preterm labour 39.39% (26/66) and only few, 9.09% (6/66) ended up with incomplete miscarriage. Spotting was most common nature of bleeding per vagina 41.66%, (50/120). On follow-up of 60 (90.9%) viable pregnancies, PIH was in 12 (20%) cases and abruption was seen in one (1.6%). Majority of preterm babies 65.4%, (17/26) Needed Neonatal Intensive Care Unit (NICU) admission. Conclusion: Vaginal bleeding in first trimester is an indicator of the maternal and foetal adverse consequences and results of this study can enrich our knowledge to plan and manage these pregnant women adequately.
Correlation of Suppression of Tumourigenicity 2 with hsCRP, NT-proBNP and Left Ventricular Ejection Fraction in Patients with Myocardial Infarction
Authors: Khan Mainuddin , Bahulikar Arun , Tambolkar Ajit , Patel Divya , Phalgune Deepak Sadashiv
Published: September 2022

Introduction: Soluble Suppression of Tumourigenicity 2 (sST2) represents a clinically relevant biomarker and has predictive evidence in acute Myocardial Infarction (MI) and predicts cardiovascular death and risk of heart failure development in these patients. The data about the correlation of sST2, N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) and high-sensitivity C-reactive protein (hsCRP)in the Indian population is lacking. Aim: To find a correlation of ST2 level at the time of admission with NT-proBNP, hsCRP and Left Ventricular Ejection Fraction (LVEF) in patients with MI, and the association of ST2 levels with mortality. Materials and Methods: This longitudinal observational study was conducted at Poona Hospital and Research Centre, Pune, Maharashtra, India, between June 2018 and August 2019, among 75 myocardial infarction patients above 18 years of age. ST2, NT-proBNP and hsCRP levels were checked within 6 hour of hospitalisation. The primary outcome measures were to study the correlation of ST2 levels at the time of admission with hsCRP, NT-proBNP and LVEF. The secondary outcome measures were to study the association of ST2 levels with in-hospital and onemonth mortality. The medians of continuous variables of two groups and three groups were-tested using the Mann-Whitney U test and Kruskal-Wallis H test respectively. The correlation analysis was performed using Spearman’s method. Results: The mean age of the study population was 57.8±7.2 years. The mortality rate was 60% (12/75). ST2 levels showed a statistically significant positive correlation with NT-proBNP (r =0.703, p-value=0.001) and hsCRP (r=0.873, p-value=0.001), whereas, ST2 levels showed a negative correlation with LVEF (r=- 0.711, p-value=0.001) in MI patients. The median ST2 levels were significantly higher in-hospital (215.3 ng/dL vs 94 ng/dL) and one month (219.5 ng/dL vs 92.0 ng/dL) mortality as compared to survived MI patients. Conclusion: ST2 levels showed a statistically significant positive correlation with NT-proBNP and hsCRP and were associated with in-hospital and one month mortality in MI patients.
Prevalence of Asymptomatic Otitis Media with Effusion in Children with Adenoid Hypertrophy and its Relation to Adenoid Size: A Cross-sectional Study
Authors: Augustian Sherin Maria , Vasu Rajan Kezhaeplackal , Reynolds Anjana Mary
Published: September 2022

Introduction: Otitis Media with Effusion (OME) occurs as a sequela of adenoid hypertrophy. But most often hearing loss due to OME goes unnoticed in children. This causes poor cognitive development, inattention and thus poor scholastic performance. Aim: To estimate the frequency of asymptomatic OME in children with adenoid hypertrophy and to find the association between adenoid size and occurrence of OME and hearing loss. Materials and Methods: The present study was a prospective cross-sectional study conducted in a tertiary care centre in South India from November 2019 to November 2021. Children of 5-12 years of age, with symptoms suggestive of adenoid hypertrophy and with no complaints of hearing loss, were selected. A detailed ear, nose, throat examination, Pure Tone Audiometry (PTA) and tympanometry were done in all patients. Adenoid size was graded by nasal endoscopy using Mc Murray and Clements scale and also based on radiographs (comparing the distance between maximum convexity of adenoid and line drawn along basiocciput (A) and posterior part of hard palate and sphenobasioccipital synchondrosis (N)) using A/N ratio. All patients subsequently underwent adenoidectomy. Myringotomy was done along with adenoidectomy in cases with bilateral OME. All OME patients were followed-up with tympanometry, one month and three months postoperatively. The frequency of OME was presented as percentage. The association between adenoid size and asymptomatic OME as well as hearing loss was done using Fisher's exact test. Results: A total of 150 children between 5-12 years with adenoid hypertrophy were analysed. The mean age was 9 years. On analysing the association between adenoid size (both radiographically and endoscopically) and OME, 30 (20%) had bilateral effusion and 18 (12%) had unilateral effusion and prevalence of asymptomatic OME was calculated as 32%. Most of the patients had Grade 2 adenoids radiographically, and Grade 3 adenoids as per nasal endoscopy. Majority of patients had Type B Tympanogram. There was significant association between OME and adenoid size. Association between adenoid size with hearing loss showed significant association between the two with p=0.001 on right ear and p<0.001 on left ear (radiographically), and p=0.0027 on right ear and p=0.043 on left ear (as per nasal endoscopy). About 93% of children with bilateral Type B tympanogram and all children with unilateral Type B and bilateral Type C returned to normal on three months follow-up. Conclusion: There was association between adenoid size, and occurrence of OME and hearing loss. About 32% of the study population were detected to have asymptomatic OME.
Relationship between the Profile Characteristics of Farmers with their Attitude towards Integrated Farming System in Kerala
Authors: Chandran Vani , Chakravarty Ritu
Published: September 2022

Farmers attitude towards any developmental activity is a priceless resource to policy makers for designing policies in order to reduce vulnerabilities of farmers. Farmers' attitudes toward Integrated Farming System have a significant impact on its upkeep. There are certain factors that influencing the attitude of a person. Therefore, by analyzing these factors, better strategy can be formulated for developing a positive attitude among the farmers. Here an attempt was made in order to identify the factors influencing the attitude of farmers in Kerala towards integrated farming systems during 2021-2022. In order to get a complete image of Kerala, three districts were randomly selected and from each district 60 IFS units were selected randomly from four panchayats to understand the relationship between the profile characteristics of farmers with their attitude towards integrated farming system. This will help the extension workers and policy makers to formulate new policies based on their profile characteristics. From the analysis conducted, it was found that among the selected independent variables farm size, experience in farming, mass media exposure, extension participation, economic motivation, training undergone were positively and significantly correlated to attitude towards IFS at 1 per cent level of significance. Whereas social participation was positively and significantly correlated to attitude at 5 per cent level of significance.
Moderating Role of Agility in the Relationship between Perceived Organizational Support and Perceived Supervisor Support for Organizational Change at PT PLN (Persero)
Authors: Siddik Aldio Fikri , Ahadiat Ayi , Hayati Keumala
Published: September 2022

Aims: Change is something that every company must deal with on a regular basis. This is a critical issue for every company or organization. Today's TUNA and VUCA organizational settings need adaptability and a learning culture. The purpose of this research is to look at the link between organizational change and agility at PT PLN by using felt organizational support and perceived supervisor support as study mediators.

Study Design / Methodology: The study's sample included 275 PT PLN (Persero) of 43.475 workers The analytical approach used in this investigation was structural equation modeling (SEM). Perceived Organizational Support (POS) and Perceived Supervisor Support (PSS) were revealed to have an influence on agility

Results: Organizational transformation is unaffected by perceived organizational support (POS), although it is impacted by it (POS). Furthermore, in terms of organizational change, agility influences the link between perceived organizational support and perceived supervisor support.

Implications: According to the research, PT PLN (Persero) has to concentrate more on its personnel and conduct yearly organizational health index surveys, as well as cultural and cultural surveys. Identifying areas for improvement so that greater action may be taken to avoid future dangers.
Diversity of Invasive Alien Dicot Species in Pantnagar, Uttarakhand, India
Authors: Verma Smriti Raj , Joshi Sangeeta , Rawat D. S.
Published: September 2022

Objective: Regular assessment of invasive species is essential to understand the status of flora in any area. The current study is the result of a floristic survey of wild dicotyledonous angiospermic plants of Pantnagar, Uttarakhand, India.

Methods: For the study, field surveys were conducted from the year 2016-2022. Plant specimens were collected, dried, poisoned and herbarium were prepared. Specimens were identified with the help of various Floras.

Results: Anthropogenic stresses on the vegetation are on high in the area in the form of intensive agricultural farming, industrial activities, university campus activities, roads and traffic, parks and playgrounds and continuous removal of natural wild vegetation. The natural tarai vegetation of the region is nearly lost or found in patches while a major portion of the vegetation is composed of invasive alien plant species (IAPS). Two assessments of invasive alien angiosperm species have been carried out in the area during the last decade in 2011 and 2015. These assessments reported the presence of 52 species [16] and 85 species [17] of invasive alien dicot plants. The current study, however, reveals the presence of 105 invasive alien dicot species (IADS) from the study region. This large increment of more than 23 % in the IADS in such a short span of time reflects the poor state of natural vegetation and high degree of anthropogenic activities in the area. The nativity analysis revealed the dominance of South American elements (53.33%) in the invasive alien dicot flora of the study region, followed by Tropical American, African and North American elements.
Does Nifuroxazide Enhance the Effect of Metronidazole Oral Administration in the Treatment of Clostridium difficile Infection?
Authors: Rahimić Jasna , Alibegović Ervin , Kurtćehajić Admir , Lekić Lana , Alibegović Dino , Dautović Esmeralda
Published: September 2022

Aims: To evaluate the efficacy of metronidazole monotherapy and modified therapy with metronidazole + nifuroxazidefor the for treatment of a mild form of Clostridium difficile infection (CDI).

Study Design: A prospective, randomized, controlled clinical trial.

Place and Duration of Study: University of Applied Sciences Tuzla in the period from June 2018 to June 2019.

Methodology: Sixty patients were included in the study, divided into two groups. One group received standard therapy (metronidazole) for the treatment of a mild form of CDI, while the other group was treated with modified therapy (metronidazole + nifuroxazide). Subjects with a developed clinical picture and a positive toxin test for Clostridium difficile were surveyed on the day of admission, then on the 4th, 10th, 14th and 30th days from the start of therapy. The goal of the research was to determine the impact of the modified therapy protocol on the number of stools and the presence of pain compared to standard therapy.

Results: The modified therapy with metronidazole + nifuroxazide showed better pharmacological efficacy in the treatment of CDI compared to the standard therapy with metronidazole alone. The group of subjects who were treated with modified therapy reported a significantly lower number of stools (P=.001) and the absence of pain at the first and second check-ups.

Conclusion: Nifuroxazide and metronidazole represent a combination of drugs that reduce the number of stools in the shortest possible time and result in the absence of abdominal pain in patients diagnosed with a mild form of CDI.
Association Between Mental Health Conditions and Postoperative Complications After Gender-Affirming Surgery
Authors: Khusid Elizabeth , Sturgis Morgan R. , Dorafshar Amir H. , Schechter Loren S. , Olweny Ephrem O. , Cherullo Edward E. , Becerra Adán Z.
Published: September 2022

This cohort study assesses whether postoperative complications are associated with having been diagnosed with a mental health condition in patients who have undergone gender-affirming surgery.
Palladium‐Catalyzed Distal CH Functionalization of Arenes
Authors: Jin Zhong
Published: September 2022

Related to
ortho
‐CH functionalization of arenes by proximal σ‐chelation, palladium‐catalyzed distal
meta
‐ or
para
‐CH functionalization of arene substrates remains significant challenges owing to the unstable macrocyclic transition state. Through utilizing the deliberated directing templates or Pd/norbornene relay strategy, distal
meta
‐ or
para
‐CH on the phenyl ring could be efficiently functionalized in the presence of Pd catalyst. This article summarizes the recent progress about Pd‐catalyzed remote
meta
‐ and
para
‐CH functionalization of the diverse arene derivatives.