bluuebunny/crossref_metadata_2025 huggingface dataset:
A cross-mixing channel 3D-SAR micromixer with high mixing performance
Authors: Zhang Liqiang , Yu Sicheng , Hu Zhou , Zhu Chenxi , Shi Jiakang , Babangida Abubakar Ahmad , Ge Daohan
Published: April 2022

As an important part of laboratory-on-a-chip (LOC) and micro-total analysis system (μTAS), micromixers are widely used in the fields of biological analysis and chemical synthesis. Most of them are used for the pretreatment of the detection and analysis system to realize the full mixing between the sample and the target to improve the accuracy of the inspection system. A new type of 3D-SAR micromixer with cross-channel structures was put forward after the systemic simulation by using CFD software. The mixing performance and mechanism of 3D-SAR micromixer with/without cross-mixing channel has been investigated with different Reynolds numbers (Re). The results show that the 3D-SAR micromixer with or without cross-mixing channel structures are of excellent mixing performance when the Re was high (Re > 50), and the mixing index is close to 1. While the concentration stratification of the two fluids in the cross-mixing channel (CMC) 3D-SAR micromixer is obviously better than that of no-cross-mixing channel (NCMC) 3D-SAR micromixer when Re is low (Re < 10). It is because the two fluids in the cross-mixing channel rotate counterclockwise at the mixing unit, which induces a vortex and increases the contact area between the two fluids. The mixing performance is greatly improved, and the mixing index at the outlet is more than 0.9. Meanwhile, in order to optimize the higher pressure drop of the CMC micromixer, a new 3D-SAR micromixer with the unbalanced-cross-mixing channel (UCMC) is proposed based on the CMC structure. This channel structure can meet the requirements of high mixing index and low-pressure drop at the same time, which is helpful to design and manufacture of new type micromixer.
Redetermination of the Fe–Pt phase diagram by using diffusion couple technique combined with key alloys
Authors: Wen Zunhong , Wang Yanglin , Wang Cong , Jiang Min , Li Hongxiao , Ren Yuping , Qin Gaowu
Published: April 2022

Fe–Pt intermetallic nanocrystals exhibit good chemical stability and unique magnetic and catalytic properties. However, there are still some discrepancies with regard to the order–disorder transitions of Fe–Pt phases, and experimental works reported for the phase equilibria of Fe–Pt alloys at low temperatures are scarce. Therefore, in this work, the phase equilibria and phase transformations of Fe–Pt alloys were systematically studied by using the diffusion couple technique combined with key alloys through electron probe microanalysis, X-ray diffraction and differential scanning calorimetry. As a result, the composition ranges of the ordered L12-Fe3Pt, L10-FePt and L12-FePt3 phases, especially at low temperatures, have been well determined, and the related invariant reactions have been evaluated. Finally, a revised Fe–Pt phase diagram has been proposed.
On the Implementation of Approximate Randomization Tests in Linear Models with a Small Number of Clusters
Authors: Cai Yong , Canay Ivan A. , Kim Deborah , Shaikh Azeem M.
Published: April 2022

This paper provides a user’s guide to the general theory of approximate randomization tests developed in Canay, Romano, and Shaikh (2017a. “Randomization Tests under an Approximate Symmetry Assumption.” Econometrica 85 (3): 1013–30) when specialized to linear regressions with clustered data. An important feature of the methodology is that it applies to settings in which the number of clusters is small – even as small as five. We provide a step-by-step algorithmic description of how to implement the test and construct confidence intervals for the parameter of interest. In doing so, we additionally present three novel results concerning the methodology: we show that the method admits an equivalent implementation based on weighted scores; we show the test and confidence intervals are invariant to whether the test statistic is studentized or not; and we prove convexity of the confidence intervals for scalar parameters. We also articulate the main requirements underlying the test, emphasizing in particular common pitfalls that researchers may encounter. Finally, we illustrate the use of the methodology with two applications that further illuminate these points: one to a linear regression with clustered data based on Meng, Qian, and Yared (2015. “The Institutional Causes of china’s Great Famine, 1959–1961.” The Review of Economic Studies 82 (4): 1568–611) and a second to a linear regression with temporally dependent data based on Munyo and Rossi (2015. “First-day Criminal Recidivism.” Journal of Public Economics 124: 81–90). The companion R and Stata packages facilitate the implementation of the methodology and the replication of the empirical exercises.
An assessment of solvers for algebraically stabilized discretizations of convection–diffusion–reaction equations
Authors: Jha Abhinav , Pártl Ondřej , Ahmed Naveed , Kuzmin Dmitri
Published: April 2022

We consider flux-corrected finite element discretizations of 3D convection-dominated transport problems and assess the computational efficiency of algorithms based on such approximations. The methods under investigation include flux-corrected transport schemes and monolithic limiters. We discretize in space using a continuous Galerkin method and ℙ1 or ℚ1 finite elements. Time integration is performed using the Crank–Nicolson method or an explicit strong stability preserving Runge–Kutta method. Nonlinear systems are solved using a fixed-point iteration method, which requires solution of large linear systems at each iteration or time step. The great variety of options in the choice of discretization methods and solver components calls for a dedicated comparative study of existing approaches. To perform such a study, we define new 3D test problems for time dependent and stationary convection–diffusion–reaction equations. The results of our numerical experiments illustrate how the limiting technique, time discretization and solver impact on the overall performance.
A divergence-free finite element method for the Stokes problem with boundary correction
Authors: Liu Haoran , Neilan Michael , Baris Otus M.
Published: April 2022

This paper constructs and analyzes a boundary correction finite element method for the Stokes problem based on the Scott–Vogelius pair on Clough–Tocher splits. The velocity space consists of continuous piecewise polynomials of degree k, and the pressure space consists of piecewise polynomials of degree (k – 1) without continuity constraints. A Lagrange multiplier space that consists of continuous piecewise polynomials with respect to the boundary partition is introduced to enforce boundary conditions and to mitigate the lack of pressure-robustness. We prove several inf-sup conditions, leading to the well-posedness of the method. In addition, we show that the method converges with optimal order and the velocity approximation is divergence-free.
Investigating the safety and feasibility of osteopathic medicine in the pediatric oncology outpatient setting
Authors: Belsky Jennifer A. , Stanek Joseph R. , Rose Melissa J.
Published: April 2022

Context

Pediatric patients receiving chemotherapy experience unwanted therapy-induced side effects, commonly constipation and pain that diminish quality of life. To date, few studies have investigated the safety and feasibility of osteopathic manipulative treatment (OMT) in pediatric oncology.

Objectives

The primary objective of this study is to investigate the safety and feasibility of OMT in pediatric oncology outpatient clinics.

Methods

This is a single institutional pilot study evaluating children aged ≥2–21 years receiving chemotherapy for an oncological diagnosis at Nationwide Children’s Hospital (NCH). Permission was obtained from the NCH Institutional Review Board. Participants were enrolled for 8 weeks and received weekly OMT. OMT was deemed feasible by participating in six out of eight weekly treatments, and safety was assessed through adverse event grading per Common Terminology Criteria for Adverse Events (CTCAE). During the clinic visit, patients answered validated surveys on constipation (Bristol Stool Scale) and pain (FACES Scale) pre/post-OMT. Feasibility was analyzed utilizing a one-sided exact binomial test while validated tools and adverse events were summarized descriptively.

Results

A total of 23 patients were enrolled, with 21 included in feasibility analyses. The majority of the patients were female (n=13, 61.9%), with a median age of 12 years at enrollment (range, 2.7–20.8 years). There were no serious adverse events attributed to OMT intervention, and among the patients assessed for feasibility, 100% of them participated in at least two-thirds of their weekly OMT treatments, meeting our defined feasibility criteria. The intervention lasted an average of 14.2 min (range, 7.2–19.2 min). There were no FACES or Bristol Stool Scale scores that correlated with worsening pain on constipation post-OMT intervention.

Conclusions

Pediatric oncology patients were feasibly and safely able to receive OMT during a regularly scheduled chemotherapy visit. The limitations include the small sample size. These findings support the need to further investigate the safety and feasibility, as well as efficacy, of OMT in the pediatric oncology clinical setting.
Symptoms of maternal psychological distress during pregnancy: sex-specific effects for neonatal morbidity
Authors: Weiss Sandra J. , Musana Joseph W.
Published: April 2022

Objectives

Maternal psychological distress during pregnancy has been associated with preterm birth. However, little is known about the relationship of a woman’s psychological symptoms during pregnancy to the infant’s morbidity at birth or any differential effects of these symptoms on female vs. male fetuses. Our research aims addressed these gaps.

Methods

A total of 186 women were enrolled between 24 and 34 weeks gestation when demographic information was acquired and they completed the Brief Symptom Inventory to measure psychological distress. Data on gestational age at birth, fetal sex, and neonatal morbidity was extracted from the medical record. To control for their effects, obstetric complications were also identified. Multiple linear regressions were computed to examine the aims, including interaction terms to measure moderating effects of fetal sex.

Results

Symptoms of maternal psychological distress were a significant predictor of neonatal morbidity but were not associated with gestational age. The interaction between symptom distress and fetal/infant sex was also significant for neonatal morbidity but not for gestational age. For boys, high levels of maternal symptom distress during pregnancy were associated with neonatal resuscitation, ventilatory assistance, and infection. Maternal distress was not associated with neonatal morbidity for girls.

Conclusions

The male fetus may be more sensitive to effects of mothers’ psychological symptoms than the female fetus. Further research is needed to confirm our findings and identify potential biological mechanisms that may be responsible for these sex differences. Findings suggest the importance of symptom screening and early intervention to reduce maternal distress and risk of neonatal morbidity.
Research progress in 3D-printed medicinal tablets
Authors: Dong Naijun , Lv Hongqian , Liu Cheng , Zhang Peng
Published: April 2022

Three-dimensional printing (3DP) is a rapid-prototyping technology that uses a digital model file to construct an object through layer printing. This novel technology is widely used in aerospace, medicine, architecture and industrial applications. However, the pharmaceutical applications of 3DP technology remain in early stages, and the pharmaceutical industry is expected to experience a revolution in 3DP. Herein, recent research progress in 3D-printed medicinal tablets is reviewed, to provide a reference for future studies and applications of 3DP technology in pharmaceutics.
Common Microscale and Macroscale Principles of Connectivity in the Human Brain
Authors: Scholtens Lianne H. , Pijnenburg Rory , de Lange Siemon C. , Huitinga Inge , van den Heuvel Martijn P. ,   Netherlands Brain Bank
Published: April 2022

The brain requires efficient information transfer between neurons and large-scale brain regions. Brain connectivity follows predictable organizational principles. At the cellular level, larger supragranular pyramidal neurons have larger, more branched dendritic trees, more synapses, and perform more complex computations; at the macroscale, region-to-region connections display a diverse architecture with highly connected hub areas facilitating complex information integration and computation. Here, we explore the hypothesis that the branching structure of large-scale region-to-region connectivity follows similar organizational principles as the neuronal scale. We examine microscale connectivity of basal dendritic trees of supragranular pyramidal neurons (300+) across 10 cortical areas in five human donor brains (1 male, 4 female). Dendritic complexity was quantified as the number of branch points, tree length, spine count, spine density, and overall branching complexity. High-resolution diffusion-weighted MRI was used to construct white matter trees of corticocortical wiring. Examining complexity of the resulting white matter trees using the same measures as for dendritic trees shows heteromodal association areas to have larger, more complex white matter trees than primary areas (p< 0.0001) and macroscale complexity to run in parallel with microscale measures, in terms of number of inputs (r= 0.677,p= 0.032), branch points (r= 0.797,p= 0.006), tree length (r= 0.664,p= 0.036), and branching complexity (r= 0.724,p= 0.018). Our findings support the integrative theory that brain connectivity follows similar principles of connectivity at neuronal and macroscale levels and provide a framework to study connectivity changes in brain conditions at multiple levels of organization.

SIGNIFICANCE STATEMENTWithin the human brain, cortical areas are involved in a wide range of processes, requiring different levels of information integration and local computation. At the cellular level, these regional differences reflect a predictable organizational principle with larger, more complexly branched supragranular pyramidal neurons in higher order regions. We hypothesized that the 3D branching structure of macroscale corticocortical connections follows the same organizational principles as the cellular scale. Comparing branching complexity of dendritic trees of supragranular pyramidal neurons and of MRI-based regional white matter trees of macroscale connectivity, we show that macroscale branching complexity is larger in higher order areas and that microscale and macroscale complexity go hand in hand. Our findings contribute to a multiscale integrative theory of brain connectivity.
The evolution of Haudenosaunee food guidance: Building capacity toward the sustainability of local environments in the community of Six Nations of the Grand River
Authors: Tait Neufeld Hannah , Xavier Adrianne
Published: April 2022

The emerging literature on the Indigenous food movement identifies community involvement, family-centred food education and re-establishing a relationship with the land as essential to restoring sustainable food systems, land and water access. These processes of reclamation have similarly evolved through collaborative community processes and guiding practices described in this chapter that have taken place in the community of Six Nations of the Grand River. The evolution of social movements and relationships to reinforce patterns of support through the transference of knowledge has led to the “guidance” that continues to adjust and change. This unique form of guidance is not in the form of a westernized practice of creating formalized lists meant for general distribution with the intent of controlling food-based practices. In the community of Six Nations, guidance and practice are informed and conveyed by people and supported through established networks and relationships. This type of guidance, therefore, is living and continues to evolve. As such it is not conveyed in such a prescriptive manner using lists and absolute categories. The Haudenosaunee food guide illustrated in Figure 2 is based on collective knowledge and land-based practices that are meant to be shared, adapted and applied by all members of the community. It is therefore not a static form of guidance as the foods and their connections to land and people evolve as reciprocal relationships.
“Good healthy food for all”: Examining FoodShare Toronto´'s approach to critical food guidance through a reflexivity lens
Authors: Manganelli Alessandra , Esteron Fleur
Published: April 2022

By building community-based food systems informed by transformative ideologies and principles, Community-Based Food Organisation (CBFOs) can be understood as agents of critical food guidance from the bottom-up. This paper focuses on the notion of reflexivity as pivotal to the implementation of critical food guidance in CBFOs. Reflexivity is defined as the capacity of actors and organisations to establish as well as to self-reflect upon key food system principles and scale out these principles across communities. To examine reflexivity and its connection to critical food guidance, this paper retraces the story of FoodShare Toronto, a CBFO whose core mission is to foster “good healthy food for all”. Going through different stages of its life-course, this paper highlights the ways in which this organisation reframes core values and principle through time and how it attempts to scale out these principles through partnerships and programs. Learning from FoodShare´s trajectory, this paper highlights key lessons on how reflexivity can strengthen the capacity of food organisations to be vehicles for emancipatory and transformative food guidance.
Religious food guidance
Authors: Desjardins Michel
Published: April 2022

This article reviews some of the ways in which food intersects with religion and argues that people’s religious food habits prepare them to critically engage the food they eat. Religious food guidance is presented through five categories: permanent food restrictions, temporary food restrictions, food offerings, charity, and food for special occasions. The underlying rationale behind these food habits, and religion in general, allows religious people to be fully engaged in current discussions about how to align eating with best practices globally.
Die elektronische Schuldverschreibung – eine Sache?
Authors: Casper Matthias , Richter Ludwig
Published: April 2022

Der Gesetzgeber verfolgt mit dem eWpG eine vorsichtige Evolution des Wertpapierrechts. Eine zentrale Rolle spielt dabei § 2 Abs. 2 eWpG. Demnach sind elektronische Schuldverschreibungen im Sinne des Gesetzes rechtlich ebenso zu behandeln wie physische Wertpapiere. Mit § 2 Abs. 3 eWpG streicht das Gesetz zusätzlich heraus, dass elektronischen Wertpapieren Sacheigenschaft zukommt. Der Beitrag geht der Frage nach, wie sich die beiden Fiktionen zueinander verhalten und welche Rechtsfolgen sich aus ihnen ergeben. Auch wenn die pfadabhängige Herangehensweise des Gesetzgebers kaum zu großen Problemen im praktischen Umgang mit dem Gesetz führen dürfte, zeigt der Beitrag doch auf, dass ein mutigerer Schritt nach vorne Praxis und Rechtsdogmatik wieder näher zusammengebracht hätte.
Pirfenidone for Idiopathic Pulmonary Fibrosis and Beyond
Authors: Aimo Alberto , Spitaleri Giosafat , Nieri Dari , Tavanti Laura Maria , Meschi Claudia , Panichella Giorgia , Lupón Josep , Pistelli Francesco , Carrozzi Laura , Bayes-Genis Antoni , Emdin Michele
Published: April 2022

Pirfenidone (PFD) slows the progression of idiopathic pulmonary fibrosis (IPF) by inhibiting the exaggerated fibrotic response and possibly through additional mechanisms, such as anti-inflammatory effects. PFD has also been evaluated in other fibrosing lung diseases. Myocardial fibrosis is a common feature of several heart diseases and the progressive deposition of extracellular matrix due to a persistent injury to cardiomyocytes may trigger a vicious cycle that leads to persistent structural and functional alterations of the myocardium. No primarily antifibrotic medications are used to treat patients with heart failure. There is some evidence that PFD has antifibrotic actions in various animal models of cardiac disease and a phase II trial on patients with heart failure and preserved ejection fraction has yielded positive results. This review summarises the evidence about the possible mechanisms of IPF and modulation by PFD, the main results about IPF or non-IPF interstitial pneumonias and also data about PFD as a potential protective cardiac drug.
Plant density on yield of Husk tomato (Physalis ixocarpa Brot.) in field and greenhouse
Authors: Ramos-López Bernabé Ignacio , Ortiz-Hernández Yolanda Donají , Morales Isidro , Aquino-Bolaños Teodulfo
Published: April 2022

ABSTRACT: Physalis ixocarpa Brot. (tomatillo or Husk tomato) is one of the five major vegetables cultivated in Mexico, but its yield in the field is low. However, greenhouse crops and the enhancement in plant density can promote an increase in yield per area. The aim of this research was to evaluate: yield, water consumption and water use efficiency of variety husk tomato ‘Diamante’. The experiment was conducted under field and greenhouse conditions, during the two crop cycles (autumn-winter and spring-summer), with different planting densities (1.5, 2 and 3 plants m-2), in complete random blocks and three replications. The yield was influenced by the planting density and environments. In both environments, the planting density, with 3 plants m-2 increased yield 32 %, and 25% in water use efficiency (WUE). In greenhouse increased 32% yield m-2 and the WUE it was 18.1 kg m-3 while in the field was 16.4 kg m-3. Crop cycle spring-summer produced differences of 27% in plant length and 15% in stem diameter, probably due to the temperature that was 4 ºC higher with respect to autumn-winter.
Heat recovery and thermal energy storage potential using buried infrastructure in the UK
Authors: Loveridge Fleur , Schellart Alma , Rees Simon , Stirling Ross , Taborda David , Tait Simon , Alibardi Luca , Biscontin Giovanna , Shepley Paul , Shafagh Ida , Shepherd Will , Yildiz Anil , Jefferson Bruce
Published: April 2022

Dispersed space heating alone accounts for 40% of UK energy use and 20% of carbon dioxide (CO2) emissions. Tackling heating and building cooling demands is therefore critical to achieve net-zero ambitions in the UK. The most energy-efficient way to reduce the carbon dioxide emissions of heating and cooling is through the use of ground-source heat pumps and district heating technology. However, capital costs are often high, sometimes prohibitively so. To reduce investment costs, it is proposed to use buried infrastructure as sources and stores of thermal energy. Barriers to this innovative approach include lack of knowledge about the actual net amount of recoverable energy and impacts on the primary function of any buried infrastructure, as well as the need for new investment and governance strategies integrated across the energy and infrastructure sectors. Additional opportunities from thermal utilisation in buried infrastructure include the potential mitigation of damaging biological and/or chemical processes that may occur. This paper presents a first assessment of the scale of the opportunity for thermal energy recovery and storage linked to new and existing buried infrastructure, along with strategic measures to help reduce barriers and start the UK on the journey to achievement of its infrastructure energy potential.
The Importance of Technology in Banking during a Crisis
Authors: Pierri Nicola , Timmer Yannick
Published: April 2022

What are the implications of information technology (IT) in banking for financial stability? Data on US banks' IT equipment and the background of their executives reveals that higher pre-crisis IT adoption led to fewer non-performing loans and more lending during the global financial crisis. Empirical evidence indicates a direct role of IT adoption in strengthening bank resilience; this includes instrumental variable estimates exploiting the historical location of technical schools. Loan-level analysis shows that high-IT banks originated mortgages with better performance, indicating better borrower screening. No evidence points to offloading of low-quality loans, differences in business models, or enhanced monitoring.
King v De Jager: Implications for Religious Based Discrimination in Wills
Authors: Osman Fatima , Effendi Gökșen
Published: April 2022

In King v De Jager 2021 5 BCLR 449 (CC), the Constitutional Court held that a clause in a private will that unfairly discriminated against beneficiaries based on gender was unlawful and unenforceable. This note considers the implications of the judgment for religion-based discrimination in wills, and in particular wills that incorporate the gender-discriminatory Islamic system of inheritance. After explaining the Constitutional Court judgment, the note argues that the Court was well within its powers to consider the enforceability of discrimination in the private sphere. More importantly, we argue that the case rings a bell of caution regarding gender-discriminatory provisions in private wills. Gender-based discrimination in Islamic inheritance law perpetuates disadvantage against a historically disadvantaged group, and the courts and legislature have been emphatic in their stance against gender discrimination in inheritance. The note thus argues that a testator's religious beliefs are not enough to tip the scales and render gender discrimination justifiable. We urge individuals who want to dispose of their assets following their religious beliefs to seek estate planning advice, cognisant of the potential impact of King v De Jager CC
[RETRACTED] Niva CBD Gummies Reviews (Shocking Side effects) Consumer Scam? v1
Authors: not provided nivagummiesreviews
Published: April 2022

[RETRACTED]

Niva CBD Gummies Reviews (Shocking Side effects) Consumer Scam?
[RETRACTED] Second Century CBD Gummies - Well Known At This Point? v1
Authors: Douglas Morris H
Published: April 2022

[RETRACTED]

If you’re one of those persons who has a hectic schedule and can’t seem to find time to work out, this product is for you.
[RETRACTED] Younabis CBD Gummies | Health Benefits of CBD Younabis — And A Look at Side Effects (Legit Or Scam?) v1
Authors: CBD Gummies Younabis
Published: April 2022

[RETRACTED]

Younabis CBD Gummies | Health Benefits of CBD Younabis — And A Look at Side Effects (Legit Or Scam?)
[RETRACTED] KetoSlim Supreme Gummies - Legit Ingredients Or Scam? New Report!! v1
Authors: Douglas Morris H
Published: April 2022

[RETRACTED]

Almost anybody can benefit from this technique by enhancing their health and resolving all of their common health issues. Numerous people use this strategy on a daily basis to effect positive changes in their lives, and many report that it works. Additionally, by ingesting it on a regular basis, individuals can improve mental and physical strength.
Entrenamiento en habilidades no técnicas versus entrenamiento estándar en estudiantes de internado para disminuir error médico en crisis en simulación: Ensayo Clínico Controlado Aleatorizado. Estudio TECRISIS v1
Authors: Zamudio Mario
Published: April 2022

Protocolo el estudio Tecrisis Ensayo clínico controlado
Donor Eligibility Criteria and Pancreas Recovery for HuBMAP TMC-PNNL-UF v1
Authors: Chen Jing , Campbell-Thompson Martha , E Mathews Clayton
Published: April 2022

This document outlines inclusion and exclusion criteria for pancreas donors for the Human BioMolecular Atlas Program (HuBMAP) by the Tissue Mapping Center (TMC) at the University of Florida and pancreas recovery procedures to be conducted by the Organ Procurement Organization Recovery Team. A member of the HuBMAP TMC-PNNL-UF team will accept pancreas offers using standardized inclusion and exclusion criteria for equal numbers of female and male donor with consideration for transportation issues that could delay receipt at the University of Florida. Redacted documents pertinent to donor and hospitalization course will be obtained and data entered into HuBMAP HIVE portal.
Sporcu Ruh Sağlığı Sürekliliği-Kısa Formu: Türkçeye Uyarlanması ve Psikometrik Özelliklerinin İncelenmesi
Authors: TİNGAZ Emre Ozan
Published: April 2022

Bu çalışmanın amacı, Sporcu Ruh Sağlığı Sürekliliği-Kısa Formu’nun (SRSS-KF) Türkçeye uyarlanması ve psikometrik özelliklerinin incelenmesidir. Araştırma, ölçeğin Türkçeye çevrilmesi, geçerlik ve güvenirlik olmak üzere üç aşamada yürütülmüştür. 254 (Myaş=21.96, SS=4.49) üniversiteli sporcu ile gerçekleştirilen faktör analizi sonucunda ölçeğin uyum iyiliği indekslerinin yeterli olduğu görülmüştür. Benzer ölçek geçerliği çalışması amacıyla dahil edilen Ruh Sağlığı Sürekliliği Kısa Formu, SRSS-KF ile orta düzeyde pozitif yönde ilişkilidir. Madde toplam korelasyonlarının orta ve güçlü düzeyde, Spearman-Brown iki yarım test korelasyonun oldukça yüksek olduğu sonucuna ulaşılmıştır. Ölçeğin geneli (α=.922), Sporda Öznel İyi Oluş (α=.833), Sporda Sosyal İyi Oluş (α=.840) ve Sporda Psikolojik İyi Oluş (α=.857) alt ölçekleri için Cronbach’s alpha iç tutarlık katsayıları oldukça yüksektir. İki hafta aralıklı olarak uygulanan test-tekrar test sonucunda ölçeğin zamana karşı tutarlı olduğu görülmüştür. Sonuç olarak, Sporda Öznel İyi Oluş, Sporda Psikolojik İyi Oluş, Sporda Sosyal İyi Oluş olmak üzere üç alt boyutlu ve 14 maddeli SRSS-KF geçerli ve güvenilir bir ölçme aracıdır.
Peculiarities of iron metabolism in patients with breast cancer before adjuvant chemotherapy
Authors: Blindar V. N. , Zubrikhina G. N. , Davydova T. V. , Dobrovolskaya M. M. , Khagazheeva M. N. , Snegovoy A. V. , Ryabchikov D. A. , Lyubimova N. V. , Kushlinsky N. E. , Kononenko I. B.
Published: April 2022

Introduction. Numerous studies using multivariate analysis have confirmed the relationship between low hemoglobin and / or hypoxia of tumor tissue with a worsening prognosis.

The study objective was to assess the state of iron metabolism in breast cancer patients in the perioperative period, before conducting adjuvant chemotherapy for adequate administration of iron and recombinant erythropoietins preparations.

Materials and methods. The object of the study included 17 breast cancer patients with a relatively favorable prognosis, with luminal types A and B (Her 2 / neu positive or negative), three times negative type. The examination was carried out in the postoperative period, before the first course of adjuvant chemotherapy. The main metabolites of ferrokinetics were studied: hepcidin 25 (GP25), ferritin, soluble transferrin receptors, transferin, iron, erythropoietin, C-reactive protein and interleukin 6 indicators.

Results. In patients with breast cancer, even before adjuvant chemotherapy, a violation of iron metabolism was revealed. Anemic syndrome (AS) with iron deficiency erythroproiesis was diagnosed in 29.4 % of them. In most of them, AS was accompanied by a deficiency of endogenous erythropoietin. Iron deficiency anemia was more common; functional iron deficiency (FID) was found in some patients. In contrast to patients with iron deficiency anemia, patients with FID had a significant concentrations of GP25, C-reactive protein, and interleukin 6 and ferritin were within the upper limit of normal. It should be noted that GP25 hyperexression was observed not only in breast cancer patients with FID, but also in patients without laboratory signs of anemia, which did not exclude the latent stage of AS.

Conclusion. To achieve the effectiveness of the treatment of AS, a comprehensive and personalized approach is required. Iron preparations are prescribed to restore iron metabolism; recombinant erythropoietins preparations are used to increase the rate of erythrocyte formation during chemotherapy. The same treatment regimen is justified for the correction of AS with FID. However, the strategy for future treatment of FID is associated with the use of GP25 antagonists (in order to overcome the retention of iron in the reticuloendothelial system), hormones or cytokines that can effectively stimulate erythropoiesis in AS with impaired iron metabolism.
Bone marrow B-lymphocyte subpopulations of breast cancer patients in the prognosis of the disease
Authors: Berdova F. K. , Vorotnikov I. K. , Tupitsyn N. N.
Published: April 2022

Introduction. Among the immunological prognostic factors in breast cancer, intratumoral lymphocytes play an important role. Pronounced infiltration of the tumor by CD8 lymphocytes is associated with a favorable prognosis. The expression of transferrin receptor (CD71) on tumor cells, on the contrary, is associated with an unfavorable prognosis. The bone marrow of breast cancer patients has been studied very little in terms of the prognostic role of hematopoietic cells and lymphocyte subpopulations.

The study objective was to investigate the bone marrow B-lymphocyte subpopulations of breast cancer patients and evaluate their prognostic value.

Materials and methods. Detailed bone marrow studies were carried out in 107 patients who were treated in the department of mammary gland tumors mainly in the period 2013–2016. Thus, the duration of the follow-up period after surgical treatment was mainly from 5 to 8 years. W hen diagnosing patients, a standard study of the receptor status, Her2 / neu, Ki-67 expression, etc. was performed. Morphological examination of the bone marrow (myelogram) was performed in all patients. Clarification of the life expectancy of patients was carried out by personal surveys or through the Registry Office. If possible, the life expectancy of patients, the duration of the period without progression etc. were clarified.

Results. In cases with B-lymphocytes of more than 10 %, survival rates were more favorable (p = 0.019). Bone marrow B cells and, in particular, CD10‑positive B-linear precursors may have prognostic value in breast cancer. Thus, CD10 expression on 12 percent or more of bone marrow B cells of breast cancer patients was associated with a more favorable prognosis (p = 0.042). The prognostic role of the CD10 antigen was realized with a follow-up period of more than 5 years. The expression of CD38 on bone marrow B cells is a prognostically favorable factor (overall survival, p = 0.026), the role of which is realized within 5–10 days of follow-up after surgery. Bone marrow B1 lymphocytes had no association with breast cancer prognosis (overall survival), however, they were correlated (p = 0.07) with progression-free survival.

Conclusion. Total relative number of (more than 10 %) of bone marrow B-lymphocytes (CD19+) of breast cancer patients were significantly related to the more favorable prognosis (overall survival) primarily because of B-cell precursors (CD10+) CD38+ bone marrow cells were also associated with more favorable prognosis. Levels of B1‑lymphocytes (CD5+) in bone marrow lymphocytes were not related to the prognosis of breast cancer. Prognositic role of B-lineage precursors and CD38‑positive cells was noted in the periods of 5–10 years after operation.
Outcomes and complications of organ-sparing treatment of patients with tumor and tumor-like conditions of the forearm long bones
Authors: Polаtova D. Sh. , Davlatov R. R. , Abdikarimov H. G. , Islamov U. F. , Savkin A. V.
Published: April 2022

Introduction.Surgical treatment of tumors of the distal part of the forearm has always been complicated. Though there are many methods of reconstruction of defects of the long bones of this area after resection, the optimal technique is still debated.

The study objectiveis to analyze the results of surgical treatment of tumors and tumor-like conditions of the forearm long bones, rate of postoperative complications, and techniques of their correction.

Materials and methods. The article presents data on 75 patients with tumor and tumor-like conditions of the forearm long bones. Diagnosis was histologically verified. In 58 (77.3 %) patients, benign giant cell tumor was diagnosed, in 3 (4 %) patients – malignant giant cell tumor, in 3 (4 %) patients – osteogenic sarcoma, in 3 (4 %) patients – chondrosarcoma, in 6 (8 %) patients – fibrous dysplasia. All patients underwent surgical treatment of varying volume. During the study, analysis of complications of surgical treatment was performed.

Results.Postoperative complications of various nature developed in 17 (22.7 %) of 75 patients between 2 weeks and 2 years after treatment. They mostly developed after segmental resection of the forearm bones with autoplasty (38.1 %) and segmental bone resection (21.4 %), as well as after excochleation with cementoplasty (16.1 %). The most frequent complications were autotransplant lysis (in 4 (19.1 %) cases), its fracture (in 2 (9.5 %) cases), and infections and inflammatory complications (in 2 (9.5 %) cases). After segmental resection with endoprosthesis, only 1 (11.1 %) patient experienced endoprosthesis head instability in the early postoperative period which led to re-endoprosthesis. Local recurrence was observed in 6 (19.4 %) of 31 patients with gigantic-cell tumors after excochleation and in 4 (28.6 %) of 14 patients after segmental resection. In 2 (14.3 %) cases, progression of the main disease was observed in the form of pulmonary metastases.

Conclusion.Excochleation with cementoplasty is the method of choice in benign tumors of the forearm bones in the absence of soft-tissue component, destruction of the cortical layer, advancement of the tumor to the joint surface. In case of benign tumors in the absence of soft-tissue component and destruction of the cortical layer, and in the presence of tumor advancement to the joint surface, the optimal technique is segmental bone resection with substitution of the defect with endoprosthesis.
The Quality of Professional Activity and its Product in the Work of a Practical Psychologist: the Problem of Defining Evaluation Concepts, Criteria and Methods
Authors: Pakhalyan V.E.
Published: April 2022

The article continues the discussion of the topic of the quality of professional activity, raised in the previous publication together with Yu.M. Zabrodin [3]. It highlights the perspective of the problem, which is connected with the question of the nature of the links between the problem of the quality of professional activity and its professional product, which exist in the work of a practical educational psychologist. Attention is drawn to the more than once noted difficulties in identifying key concepts in this subject area and formulating their definitions. The connection between the existing difficulties and the general uncertainty (“methodological chaos”) in the current state of the methodology of practical psychology proper is traced. Specific examples are given of identifying and defining the criteria for the quality of activity and the product of the work of a practical psychologist on the materials obtained in the evaluation of works participating in professional competitions and products of activity provided by a practical psychologist (applicant for category assignment) in the certification process. The author’s understanding of further work in this area, ways to solve the problem of ensuring the quality of the work of a practical psychologist and his products of activity are proposed.
Approbation of the “Skilful Class” Program at the Center for Psychological, Pedagogical, Medical and Social Assistance
Authors: Barabanova V.V. , Shurykina S.A.
Published: April 2022

The article presents the successful experience of the “Skilful Class” program’s approbation at the State regional budgetary institution “Novgorod Regional Center for Psychological, Pedagogical, Medical and Social Assistance”. The experiment involved children of senior preschool age (6–7 years old) who do not attend preschool educational institutions. The successful mastering of general and individual skills was facilitated by the well-coordinated work of teachers and parents (legal representatives) of children, high motivation of children in mastering skills, the organization of a supportive environment both at the Center and at home. The realization of the “Skilful Class” program with the use of restorative practices contributed not only to the communicative and socio-emotional development of the children in the group but also laid a favorable basis for further formation of educational skills, successful adaptation of children to school.
Experience in Implementing the Author’s Concept of the Direction «Mentoring: Individual Personal and Professional Support for Adolescents at Risk», Carried out within the Framework of the Project «Ecosystem of Childhood»
Authors: Gorina A.L. , Lunkov D.R. , Sergreeva E.S. , Trusovich N.V.
Published: April 2022

The article is devoted to mentoring — the direction of work implemented within the framework of the project “Ecosystem of Childhood: approbation of a systemic model for the prevention of social risks in organizations for orphans and children left without parental care”, under a grant from the Department of Labor and Social Protection of Moscow in 2020–2022. Mentor is a professional tutor who works with children and adolescents living in the Centers for the Promotion of Family Education (hereinafter referred to as the CPFE) in Moscow, showing signs of maladjustment, deviant behavior (addictive, illegal, etc.), learning difficulties, unauthorized departures and etc. The basic principles and main stages of the mentor’s work are considered, as well as the experience of the first year of implementation of this author’s concept, which includes elements and technologies of psychological counseling and psychotherapy, case management, skills and recovery approaches.
Psychological Characteristics of Older Preschool Children with Phonetic and Phonemic Speech Underdevelopment
Authors: Sychenko Y.A. , Kulygina O.S.
Published: April 2022

The study aims to define the psychological characteristics of preschool children with phonetic and phonemic speech underdevelopment (FFSU). The psychological characteristics of children with FFSU are considered in connection with the preparation for school education. The hypothesis was tested: the psychological characteristics of children with FFSU significantly differ from the psychological characteristics of children with normative speech development; the structure of the correlations of psychological characteristics in the studied groups of children is different. The sample included children with FFSU (N = 30) and children with normative speech development (N = 30). Re-search methods were the Method of Express Diagnostics by N.N. Pavlova, L.G. Rudenko and Test of Anxiety by R. Tammle, M. Dorkey and V. Amen. The study results showed that the differences between children with FFSU and normative speech development manifested themselves at the level of a statistical trend in two parameters. Children with FFSU are inferior to their peers with normative speech development in arbitrariness (p = 0.052), but have a slight advantage over them in the emotional sphere due to a lower level of anxiety (p = 0.083). Correlation analysis confirmed the assumption that the structure of correlation relationships of psychological characteristics in the studied groups of children is different. In conclusion, the psychological conditions for the successful adaptation of children with FFSU to school are determined: the development of arbitrariness, attention, logical thinking, the formation of adequate self-esteem.
Description and Layout of the Website Of Digital Platform of the Model of Rehabilitation and Educational Space for Children with Disabilities
Authors: Krestnikova D.G.
Published: April 2022

The paper proposes a description of the structure and functions of the website of the model of the rehabilitation and educational space of children with disabilities in order to present the best practices of rehabilitation and education. An important task of the projected site is to ensure the functioning of the form for online consultations with the possibility of publishing the experts answers.
Monolateral spinal anesthesia
Authors: Neimark Michael I. , Burenkin Artem A.
Published: April 2022

Spinal anesthesia is a simple and affordable method of anesthesia that provides a sufficient level of intraoperative and postoperative analgesia, muscle relaxation, and early activation of patients. Like all other techniques, it has advantages and disadvantages. The most common side effect of anesthesia is the central hemodynamic disturbance, such as hypotension, which is prevented by unilateral anesthesia. Thus, presented herein are the most common complications and their prevention methods.
Problems of organizing the work of pathological and anatomical bureau (devices), forensic medical examination bureau in the conditions of COVID-19
Authors: Bogovskaya Elizaveta A. , Aleksandrova Oksana Yu. , Boroday Angelina , Zabozlajev Fedor G.
Published: April 2022

The work of medical professionals is always associated with a risk to life, but during the onset of the COVID-19 pandemic, forensic experts and pathologists were faced with the need to diagnose a new and highly contagious disease in the presence of inadequate specific methodological guidelines.
Optimization of work organization processes, analysis of risk factors for the spread of COVID-19 infection in pathological and anatomical bureaus (departments) and forensic medical examination bureaus is an urgent task of public health. Forensic pathologists and pathologists are among the most vulnerable groups of healthcare workers exposed to the risk of infection in the workplace during epidemics, pandemics, and in high-risk conditions when emerging infections such as COVID-19 coronavirus.
The purpose of the study was to analyze and identify the problems of organizing the work of persons involved in forensic medical examinations, post-mortem examinations in the context of the COVID-19 coronavirus.
The study showed that the existing regulatory organization of the work of persons involved in the conduct of forensic medical examinations, post-mortem examinations does not allow to fully ensure the structural and procedural factors that regulate the activities of the personnel of pathological bureaus (departments) and forensic medical examination bureaus under the risk of coronavirus infection COVID-19.
Pathology of COVID-19
Authors: Sagidullin Rafael H. , Khalikov Airat A. , Nazmieva Alina R. , Kuznetsov Kirill O. , Kartoeva Hyadi V.
Published: April 2022

Coronavirus infection 2019 (COVID-19) has become a challenge for the health care system around the world due to the progressive increase in the number of cases with severe manifestations of the disease. Autopsy findings are fundamental and critical to better understanding how infection affects the human body. These data are needed to improve diagnostic and treatment methods, as well as to stratify risk groups.
The purpose of the review is to analyze and summarize the pathological data available to date related to COVID-19. In COVID-19, the lungs are usually severe and swollen. Histologically, the most frequent is the detection of both exudative and proliferative diffuse alveolar injury with the formation of hyaline membranes, inflammatory cell infiltration, and stagnant small vessels. There is also evidence that SARS-CoV-2 causes endothelial dysfunction. There is still insufficient data to reflect the complete pathophysiological picture of SARS-CoV-2 infection.
Almost all of the articles reviewed in this review focused on pulmonary macro- and microscopic changes; there is little data on the features of the virus affecting other organs and its systemic effect. Despite the tremendous attention and investment in the fight against the new coronavirus infection, diagnosis of most of the deaths associated with COVID-19 is difficult.
It is necessary to conduct further pathological studies, the purpose of which should be the development of a standardized diagnostic method, as well as the isolation of pathognomonic signs of the disease.