bluuebunny/crossref_metadata_2025 huggingface dataset:
«Paperless Informatics» Today
Authors: Polak Yuri Еvgenievich
Published: October 2023

40 years ago, the book “Fundamentals of Paperless Informatics” was published. And this August, the 100th anniversary of the birth of its author, the outstanding scientist V.M. Glushkov, was celebrated. The paper contains quotations from this monograph, describes the modern development of the ideas and forecasts described in it in relation to various spheres of society.
Automatic replenishment of metadata of digital publications using semantic services of the Internet
Authors: Gafurova Polina Olegovna
Published: October 2023

The article describes approaches to supplementing metadata by means of semantic networks. A method has been developed for supplementing affiliation metadata with the help of the ROR registry - an open registry of identifiers of scientific organizations and a means of making links between ROR and other semantic networks.
Service for hosting a collection of Tatar language dictionaries
Authors: Alexandrova Irina Leonidovna , Nasrutdinov Marat Faritovich
Published: October 2023

The experience of creating software for organizing and sharing Tatar language dictionaries is described. The project started in 2018 under the leadership of the Ibragimov Institute of Language, Literature and Art of the Academy of Sciences of the Republic of Tatarstan. The aim of the project is to create and develop a multifunctional electronic collection of Tatar language 4 dictionaries. The sources of the fund are language guides (previously presented only in paper form), created in previous years at the Institute of Language, Literature and Art. The fund contains dictionaries of various types: explanatory, bilingual and multilingual, general and particular, aspect. At the moment the collection contains 49 dictionaries. The article discusses the problems of organizing a search system and working with several alphabets (Cyrillic, Latin, Arabic), methods of markup in dictionaries to support end-to-end search across all sources.
Evaluation of the Basic Designs of a Micro Device that Provides Vibrational Stimulation to Cells
Authors: Minami Kazuyuki , Nakahara Tasuku , Sato Katsuya
Published: October 2023

It is known that the cells responds to external mechanical stimulations. Although the effectiveness of vibrational stimulation for the osteoanagenesis has been reported, the clarification of detailed mechanism for this phenomenon is insufficient. In this study, a micro device has been developed to evaluate the cell dynamics and responses to vibrations. The micro device has an array of moving micro stages which have transparent 5 µm thick thin film to enable them to observe the cell responses to vibrational stimulations by using an optical microscope. The moving micro stages are moved with a needle actuated by piezo actuator. Microfabrication processes, such as conventional photolithography, lift-off, and sacrificial layer etching, were used to fabricate the micro device. We designed two types of concepts for supporting and vibrating moving micro stages. Prototypes were fabricated and evaluated under vibrational conditions. Proposed design with the moving micro stages vibrating perpendicular to the beams generated simple linear oscillation without rotation. It was verified that the fabricated micro stage could be vibrated at the acceleration amplitude of 0.1 and 0.2 G with frequency 15, 45, and 90 Hz.
Image-Based Gel Encapsulation of Suspended Single Cells for Parallel Single-Cell Screening
Authors: Selvam Venkatesh Kumar Panneer , Kamaludin Muhammad Luqman Arief Bin , Murtaza Ghulam , Chowdhury Rifat Hussain , Debnath Tanmay , Okamoto Shunya , Shibata Takayuki , Santra Tuhin Subhra , Nagai Moeto
Published: October 2023

Single-cell screening, which has revolutionized the life sciences, is an important method for detecting, separating, or treating specific cells based on desired characteristics. Previously, single cells of interest were manually identified in an image, which required human labor and time. We developed an automated photopolymerization system to encapsulate suspended single cells in approximately 50-µm photo-crosslinkable hydrogel squares. An image was captured, and single cells were selected from grouped cells based on image processing. A generated image was transferred to a digital micromirror device (DMD), and in parallel, target-suspended single cells were encapsulated in gelatin methacryloyl (GelMA) hydrogels. We built a data transfer platform based on a Power Automate Desktop (PAD), completed the data transfer, and projected the processed image onto a sample in 10 s, ensuring a minimum alignment error of 6.2 µm.
Patterning-Based Self-Assembly of Specific and Functional Structures
Authors: Kokubu Taichi , Hikida Tatsuya , Suzuki Hiroaki
Published: October 2023

In this study, we developed a system for selective self-assembly of millimeter-scale components differentiated by adhesive patterns. This was achieved by designing concentric circular patterns having different radii but the same total length of peripheries. Small polymer sheets having solder adhesive patterns in these designs were simply attached to the millimeter-scale components to be assembled in a stirring container. This strategy was effective in avoiding an overlap between different patterns and enforcing the selective bonds between identical patterns among three types of components. Finally, the selective assembly of a functional structure (i.e., poly(N-isopropylacrylamide) gel actuator) was demonstrated.
Demonstration of Snow Removal Work by Wheel Loader in an Environment Surrounded by Obstacles
Authors: Murayama Hiroto , Kawabe Tomohito , Inagawa Masahiro , Yoshizawa Keiichi , Ishibashi Munehiro , Takei Toshinobu , Nagatani Keiji
Published: October 2023

Snow removal work using construction equipment faces problems such as a shortage of skilled operators owing to the declining birthrate and aging population, work in dangerous areas, and accidents caused by a lack of concentration during long work hours. To improve the working environment, research and development of automation of construction equipment are actively conducted. Therefore, in this study, we aim to generate a driving path for wheel loaders for snow removal work in a work environment surrounded by obstacles, such as walls and fences. Furthermore, the proposed method considers the changing shape of the snow piles during the removal. We experimentally verified that snow removal could be performed using an actual wheel loader on the route generated by the proposed simulation.
Image Search Strategy via Visual Servoing for Robotic Kidney Ultrasound Imaging
Authors: Fujibayashi Takumi , Koizumi Norihiro , Nishiyama Yu , Zhou Jiayi , Tsukihara Hiroyuki , Yoshinaka Kiyoshi , Tsumura Ryosuke
Published: October 2023

Ultrasound (US) imaging is beneficial for kidney diagnosis; however, it involves sophisticated tasks that must be performed by physicians to obtain the target image. We propose a target-image search strategy combining visual servoing and deep learning-based image evaluation for robotic kidney US imaging. The search strategy is designed by mimicking physicians’ motion axis of the US probe. By controlling the position of the US probe along each of the motion axes while evaluating the obtained US images based on an anatomical feature extraction method via instance segmentation with YOLACT++, we are able to search for an optimal target image. The proposed approach was validated through phantom studies. The results showed that the proposed approach could find the target kidney images with error rates of 2.88±1.76 mm and 2.75±3.36°. Thus, the proposed method enables the accurate identification of the target image, which highlights its potential for application in autonomous kidney US imaging.
Development of Compact 3-Degree-of-Freedom Oscillatory Actuator
Authors: Heya Akira , Nakamura Ryosuke , Hirata Katsuhiro
Published: October 2023

Haptics applications are receiving increasing attention in entertainment, medical support systems, and various industries. Three-dimensional (3D) haptics is important to provide users real experiences. Conventional haptic devices consist of many motors and mechanical elements grounded in an environment. Therefore, they are large in size and heavy. Haptic devices using asymmetric vibrations can display illusion forces with mobile structures. However, they need additional structures (comprising actuators) to generate a 3D illusion force; however, the operational mechanism becomes complex. To solve this problem, we propose the use of a 3-degree-of-freedom (3DOF) oscillatory actuator that can generate a 3DOF vibration using only one actuator. This study describes the basic characteristics and operating verification of the 3DOF oscillatory actuator. The static thrust characteristics are quantified and analyzed using a finite element method. The dynamics are calculated based on numerical simulations using a dynamic model. The prototype’s experimental results show that the 3DOF actuator can generate 3DOF vibration.
Development of Tensegrity Manipulator Driven by 40 Pneumatic Cylinders for Investigating Functionality in Hyper-Redundant Musculoskeletal Systems
Authors: Yoshimitsu Yuhei , Ikemoto Shuhei
Published: October 2023

Musculoskeletal systems are characterized by their structural softness and drive redundancy. The objective of this study was to reproduce these features using a tensegrity manipulator. The developed tensegrity manipulator was formed by replacing 40 of the 80 cables of class-1 tensegrity consisting of 20 struts with pneumatic cylinders to allow it to bend actively. This paper presents the design details of the manipulator and an analysis of its characteristics during various motions. We confirmed that this robotic platform could reproduce abstract features of the musculoskeletal system. In addition, we discuss the issues that must be addressed in the control of this robot according to the experimental results.
Behavior Learning System for Robot Soccer Using Neural Network
Authors: Tominaga Moeko , Takemura Yasunori , Ishii Kazuo
Published: October 2023

With technological developments, the prospect of a human-robot symbiotic society has emerged. A soccer game has characteristics similar to those expected in such a society. Soccer is a multiagent game in which the strategy employed depends on each agent’s position and actions. This paper discusses the results of the development of a learning system that uses a self-organizing map to select behaviors depending on the scenario (two-dimensional absolute coordinates of the agent, other agents, and the ball). The system can reproduce the action-selection algorithms of all the players on a certain team, and the robot can instantly select the next cooperative action from information obtained during the game. Thus, common-sense rules can be shared to learn an action-selection algorithm for a set of both human and robot agents.
PRE-SLAUGHTER PIG WELFARE AND CARCASS AND MEAT QUALITY
Authors:   Department of Animal Nutrition and Feed Science, Wrocław University of Environmental and Life Sciences, Chełmonskiego 38c, 51-630 Wroclaw, Poland, Rybarczyk Artur , Tobolska Izabella ,   Department of Animal Nutrition and Feed Science, Wrocław University of Environmental and Life Sciences, Chełmonskiego 38c, 51-630 Wroclaw, Poland
Published: October 2023

For a large number of consumers today, primarily young ones, acceptance of a foodstuff such as meat is often linked to demands for appropriate conditions for the maintenance of productive animals, as well as proper protective treatment during transport and slaughter. The way in which commercial and slaughter animals are handled is being viewed more and more critically by the public. The increasing sensitivity of consumers to the fate of animals in recent years is also reflected in the emergence of new legislation. The quality of pork meat largely depends on how the animals are handled, and in particular on factors related to pre-slaughter marketing and the conditions of slaughter itself. During pre-slaughter marketing, the body of fattening animals and the quality of pork are particularly adversely affected by conditions during loading, transport, holding in the livestock warehouse, and slaughter. Carried out even under the best conditions, they induce a severe stress for pigs, resulting in significant reduction in the quantity and quality of meat.
Pathophysiological Mechanisms Underlying Unilateral Vocal Fold Paralysis in Female Patients: An Ultrasonographic Study
Authors: Lu Yi-An , Tsai Yun-Chen , Lin Wan-Ni , Pei Yu-Cheng , Fang Tuan-Jen
Published: October 2023

Objectives. Laryngeal ultrasonography (LUS) has been suggested as an alternative diagnostic tool for unilateral vocal fold paralysis (UVFP). The present study applied LUS and quantitative laryngeal electromyography (LEMG) in female UVFP patients to investigate the pathophysiologic mechanisms of UVFP.Methods. In this cross-sectional study, vocal fold (VF) length parameters included resting and phonating VF length measured using B-mode LUS, and color Doppler vibrating length (CDVL) measured using the color Doppler mode.Results. Forty female patients with UVFP were enrolled, among whom 11 and 29 were assigned to the thyroarytenoid (TA) muscle+cricothyroid (CT) muscle group (with CT involvement) and the TA (without CT involvement) group, respectively. In the TA group, the turn frequency in thyroarytenoid-lateral cricoarytenoid (TA-LCA) on the paralyzed side, as observed through LEMG, correlated with the VF length during the resting phase (R=0.368, P=0.050) and CDVL values (R=0.627, P=0.000) on the paralyzed side. In the TA+CT group, the turn ratio in the CT muscle correlated with the normalized phonatory vocal length change (nPLC; R=0.621, P=0.041) on the paralyzed side.Conclusion. CDVL and nPLC are two parameters that can be utilized to predict the turn frequencies of TA-LCA in UVFP cases without CT involvement, and the turn ratio of CT in cases of UVFP with CT involvement, respectively. The findings suggest that LUS, as a noninvasive tool, can serve as an alternative method for assessing the severity of laryngeal nerve injury and offer valuable insights into the pathophysiology of UVFP.
Role of the Paraspinal Muscles in the Sagittal Imbalance Cascade
Authors: Han Gengyu , Zhou Siyu , Qiu Weipeng , Fan Zheyu , Yue Lihao , Li Wei , Wang Wei , Sun Zhuoran , Li Weishi
Published: October 2023

Background:

The role of paraspinal muscle degeneration in the cascade of sagittal imbalance is still unclear. This study aimed to compare paraspinal muscle degeneration in the 4 stages of sagittal imbalance: sagittal balance (SB), compensated sagittal balance (CSB), decompensated sagittal imbalance (DSI), and sagittal imbalance with failure of pelvic compensation (SI-FPC). In addition, it aimed to compare the effects paraspinal muscle endurance and morphology on sagittal spinopelvic alignment in patients with lumbar spinal stenosis.

Methods:

A cross-sectional study of 219 patients hospitalized with lumbar spinal stenosis was performed. The isometric paraspinal extensor endurance test and evaluation of atrophy and fat infiltration of the paraspinal extensor muscles and psoas major on magnetic resonance imaging were performed at baseline. Spinopelvic parameters including lumbar lordosis, pelvic tilt, sacral slope, pelvic incidence, and the sagittal vertical axis were measured.

Results:

The patients with lumbar spinal stenosis were divided into 67 with SB, 85 with CSB, 49 with DSI, and 17 with SI-FPC. There were significant differences in paraspinal muscle endurance and morphology among the 4 groups. Furthermore, the SI-FPC group had poorer paraspinal muscle endurance than either the SB or the CSB group. In multiple linear regression analysis, paraspinal muscle endurance and the relative functional cross-sectional area of the paraspinal extensor muscles were the independent predictors of the sagittal vertical axis, and the relative functional cross-sectional area of the psoas major was the independent predictor of relative pelvic version.

Conclusions:

This study indicated that paraspinal muscle degeneration is not only an initiating factor in pelvic retroversion but also a risk factor for progression from a compensated to a decompensated stage. Specifically, the impairment of muscle endurance in the CSB stage may be the reason why patients experience failure of pelvic compensation. In addition, paraspinal muscle endurance and muscle morphology (relative functional cross-sectional area of the paraspinal extensor muscles and psoas major) had different clinical consequences.

Level of Evidence:

Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
CONSEQUENCES OF ORGANIZATIONAL OUTCOMES OF JOB INSECURITY IN ORGANIZATIONS
Authors:   Asma Gul
Published: October 2023

Job insecurity is the prevailing phenomenon in today’s organizations. This cross-sectional study is examined from the private sector organizations of Pakistan where the vital existence perceived job insecurity has been observed. Information collection was conducted within the spring of 2020 as part of a program of study for part-time MBA from Riphah International University. (N=202) were guaranteed of secrecy, seem skip study things or segments in case awkward, and gotten course credit for taking an interest.
Chronozonal Structure of the Mangazeya Superhorizon in Eastern Siberia and Its Place in the Global Ordovician Scale
Authors: Tesakov Yu.I.
Published: October 2023

—The chronozonal structure of the Mangazeya Superhorizon of Eastern Siberia, which includes the Listvyazhny and Baksan horizons and their chronozones, is considered. Their volumes and stratotypes are given and their place in the regional and global stratigraphic structure is shown, where Mangazeya occupies the middle parts of the Kuzmovsky regional complex and the Caradocian stage of the Upper Ordovician. Proper names for the Lower Dolbor Horizon (Amutkansky) and the Upper Dolbor Horizon (Cherlechinsky) are introduced for the first time.
Different Dynamics of the Chemical Composition of Water in the Baikal Ecosystem (Baikal, Its Tributaries, and the Source of the Angara River)
Authors: Grebenshchikova V.I. , Kuzmin M.I. , Demyanovich V.M.
Published: October 2023

—Multidirectional dynamics of changes in the chemical composition of the water of the only runoff of Lake Baikal, the Angara River, has been established. The cyclic-wave change in the interannual chemical composition of the Baikal water has been revealed, which indicates a long-term memory effect in the chemical time series of elements. Positive and negative temperature and chemical trends in the state of the water in the source of the Angara are observed, which are due to climate changes, the confinement of Baikal to the rift zone, and the composition of the enclosing rocks. It is shown that the current concentrations of monitored elements in the Angara source water depend also on their past concentrations but can change dramatically in the case of catastrophic environmental disturbances caused by natural and anthropogenic disasters (fires, drought, floods, earthquakes, etc.). The relationship between the elevated concentrations of uranium in the water and the seismic process in the Baikal area has been traced. The data obtained are based on the long-term (1950–2021) monitoring of the chemical composition of water in the Baikal ecosystem (Baikal, its tributaries, and Angara source).
Eoarchean to Paleoproterozoic Crust History in the Yakutian Diamond Province: Evidence from U–Th–Pb (LA-ICP-MS) and Lu–Hf Dating of Zircons from Crustal Xenoliths in Kimberlite Pipes
Authors: Shatsky V.S. , Ragozin A.L. , Wang Q.
Published: October 2023

—Radiometric dating of zircon grains from crustal xenoliths in kimberlites of the Yakutian diamond province show that most of the Daldyn and Markha terranes were formed in Paleoarchean but preserve some fragments of Eaoachean and possibly even Hadean crust recycled in several tectonothermal events. The oldest zircons were crystallized about 3.2 Ga and recrystallized during later activity stages of 2.9, 2.8–2.7, and 1.9 Ga, whereby they gained radiogenic hafnium produced by 176Lu decay in the rock. The degrees crust rework and the tectonothermal stages varied across the Anabar tectonic province. The earliest events of 3.2 and 2.9 Ga left record in zircons from kimberlites in the Nakyn field, while the signatures of the 2.7 Ga activity are best pronounced in zircons from kimberlites sampled in the Upper Muna and Nakyn fields. On the other hand, zircons from lower crustal mafic granulite xenoliths in the Daldyn and Alakit-Markha kimberlites lack traces of the earliest crust history and only evidence of the last 1.9 Ga event, which remained mute in xenolith samples from the Upper Muna field. Zircons from felsic granulite and metadiorite xenoliths in the Udachnaya kimberlite, which represent middle and upper crust, show a peak at 2.6 Ga besides that of 1.9 Ga. The synthesized available data support several previous inferences: vertical and lateral heterogeneity of the crust in the Yakutian diamond province; absence of linkage between the crust recycling degree and major collisional zones of the Siberian craton; absence of the separate Markha terrane. Correlation of age peaks corresponding to thermal events in the crust history of the Anabar tectonic province with those of large igneous provinces allows a hypothesis that the revealed tectonothermal events may be related with the activity of superplumes.
Engineering Technology Students’ Demonstration of Iterative Product Design without a Design Process Diagram
Authors: Webster Rustin , Turner Matthew
Published: October 2023

This exploratory research case study reports on outcomes and observations from a junior-level computer-aided design (CAD) elective course, which included a semester long team-based product design challenge that was weaved within the existing course curriculum. Engineering technology (ET) students’ demonstration of iterative product design, when not educated on or given a design process diagram (DPD) to reference and/or follow were explored. Two prototypes from two teams, which were designed, built, and tested over approximately six weeks are showcased. Team A completed five iterations of an enclosure body and two iterations of a lid to hold a small global positioning system (GPS) device. Team B completed four iterations of a base plate for a foot braking system. It was observed that upper-level mechanical engineering technology (MET) students did not require that the instructor teach about or provide a DPD to use/reference in order for successful iterative product design to occur. However, additional research, specifically causal, is needed investigating students’ iterative product design knowledge, skills, and abilities from other degree programs, demographics, and at different time periods of an academic plan of study (e.g., freshman, sophomore, etc.).
Sustainable thermogenic CH4 and H2 generation in the Nankai Trough subduction zone
Authors: Suzuki Noriyuki , Koike Koutaro , Kameda Jun , Kimura Gaku
Published: October 2023

Mud volcanoes, gas plumes, and gas hydrates comprising thermogenic and biogenic CH4 are widely distributed in the Nankai Trough subduction zone, showing ongoing significant CH4 activity. However, the source rocks of the thermogenic CH4 and the geological source of H2 for microbial CH4 production remain uncertain. Here, we reveal the timing and amount of the thermogenic CH4 and H2 generation in shales and metapelites during diagenesis to metamorphism and estimate their current generation in the Nankai Trough from the movements of the oceanic plate and the accretionary prisms. The results show that the thermogenic CH4 and H2 are generated mainly in the underthrust sediments below the décollement. The sustainable H2 supply from the underthrust sediments can be another potential H2 contributing to microbial CH4 production. The findings enhance our understanding of the active CH4 emission, large-scale gas hydrate formation, and subseafloor biosphere in the oceanic plate subduction zone.
High body mass index and the risk of acute exacerbations in chronic obstructive pulmonary disease: A meta-analysis and systematic review
Authors: Yang Liuqing , Wei Yuying , Ni Hangqi , Wang Qing
Published: October 2023

Background
Emerging studies indicated the beneficial role of overweight and obesity regarding the prognosis of chronic obstructive pulmonary disease (COPD). However, it’s controversial that whether high body mass index (BMI) has been associated with the risk of acute exacerbations in COPD.
Methods
Pubmed, Cochrane Library and Embase database were searched up to March 2023. All studies reported the relationship between BMI and the COPD exacerbation risk were included. The quality assessment was performed using the Newcastle Ottawa scale. The meta-analysis was carried out using Review Manager 5.4 software and StataMP 18.0 .
Results
A total of 10 studies involving 50573 participants with COPD were included. There were no statistical differences in the acute exacerbation risk for the comparison of high BMI vs. non-high BMI group (relative risks, RRs:1.01, 95%CI:0.94–1.07, p = 0.88) and high BMI vs. normal weight group (RRs: 1.01 95%CI: 0.94–1.05, p = 0.9). Further comparisons of subgroups of high BMI including overweight, obesity, Class I obesity and extreme obesity compared to normal weight group also showed no statistical differences. However, a lower risk of COPD exacerbation was discovered when comparing high weight with underweight group (RRs:0.76, 95%CI: 0.63–0.92, p = 0.005). Moreover, high weight group was associated with a lower risk of severe exacerbations of COPD compared to normal weight group (RRs:0.83, 95%CI:0.79–0.88, P < 0.001), but not differ in the risk of frequent COPD exacerbations compared to normal weight subjects (RR:0.91, 95%CI:0.79–1.05, P = 0.19).
Conclusion
The present study showed that high BMI group including overweight and obesity plays neither a beneficial nor a disadvantage role on the risk of acute exacerbations in COPD patients compared to normal weight counterparts. However, high BMI induced a lower risk of severe COPD exacerbations compared to the normal weight group and a lower risk of COPD exacerbations compared to underweight subjects.
Sustainable Value of Long-Duration Energy Storage in a Decarbonised Power System
Authors: Veremu Davis , Patwa Nitin , Seetharaman Arumugam , Abraham Christopher
Published: October 2023

Our research aims to enhance the sustainable value framework by integrating stakeholder theory in a decarbonised power system. It emphasises the importance of managing the transition to renewable energy in a stable manner, addressing the intermittency challenge. By conceptualising ultralow-cost, long-duration energy storage (LDES) as a transition pathway, the study proposes advanced adiabatic compressed air energy storage (AA-CAES) as a significant solution to manage imbalances in renewable energy generation. The research sheds light on the alignment between environmental and social benefits in utility-scale renewable energy storage, emphasising supply-side interactions, acceptance, and community engagement. The study contributes fresh perspectives to stakeholder theory and offers conceptual and quantitative analysis to enrich the literature in this field, informing both theoretical understanding and managerial decision-making.
Multidomain intervention for reversal of cognitive frailty, towards a personalised approach (AGELESS Trial): Recruitment and baseline characteristics of participants
Authors: Ibrahim Azianah Mohamad , Singh Devinder Kaur Ajit , Ludin Arimi Fitri Mat , Subramaniam Ponnusamy , -Vyrn Chin Ai , Ibrahim Norhayati , Haron Hasnah , Safien Aisyah Mohd , Khalid Norhayati Mustafa , Ponvel Pavapriya , Fad Nurul Hidayah Md , Hanipah Jamilah , Mangialasche Francesca , Kivipelto Miia , Shahar Suzana
Published: October 2023

Introduction: Reversal of cognitive frailty through a multidomain intervention is desirable to prevent dementia. AGELESS Trial was conducted with the aim to determine the effectiveness of a comprehensive, multidomain intervention on older adults with cognitive frailty (CF). However, conducting a clinical trial particularly during or post the Covid-19 pandemic posed unique challenges. Therefore, this study focuses on describing the recruitment process and baseline characteristics of the participants and adherence at one year of the trial.
Methods: Community dwelling older adults, aged 60 years old and above were screened for cognitive and physical impairment using Clinical Dementia Rating and FRIED criteria respectively. Parallel randomised controlled trial was conducted comparing multidomain module (five modules: vascular management, diet, physical exercise, cognitive and psychosocial) with usual care for 24 months.
Results: A total of 957 older adults from two locations, ie. urban (n=764) and rural (n=193) areas were screened and 38.9% had CF and eligible to participate. Those with CF had lower years of education, and cognitive status as assessed using mini mental state examination (MMSE) (p<0.05 for both parameters). Among those from urban areas, only 13.87%(n=106) agreed to participate, particularly those with multimorbidity, with a higher physical activity level and walking speed (p<0.05 for all parameters). At baseline, mean age of participants was 68.1±5.6 years, education years was 8.3 ± 3.9 years, body mass index (BMI) was 27.0± 4.8 kg/m2 and MMSE was 22.7± 4.0. Generally, there were no significant difference between intervention and control groups for main outcomes, except those in intervention group had a higher BMI, mid upper arm circumference and waist circumference (p<0.05 for all parameters). Overall adherence towards intervention at one year was 52.8 %, ranging from 60% to 91% for each of the modules. In conclusion, only one third of those who were eligible from urban area for this trial agreed to participate, particularly among those with multimorbidity, higher physical activity level and walking. Understanding factors that influence recruitment and participation is crucial in personalising the trial to the targeted group and interpreting the data within the context of the study population.
Virulence of Philippine Entomopathogenic Nematode against Fall Armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) Strains
Authors: DUZA GERALD MEDINA , LATINA ROMNICK A , YAP SHERYL A , DALISAY TERESITA U , PINILI MARITA S , CAOILI BARBARA LAVIÑA
Published: October 2023

The control of fall armyworm (FAW), Spodoptera frugiperda, has been a significant concern to the corn and rice in the Philippines. Recent research has focused on developing control strategies using biological controls such as entomopathogenic nematodes. This paper evaluated the efficacy of the Philippine isolates Heterorhabditis indica (HiBSDS, HiMAP, HiPBCB) and Steinernema abbasi (SaMBLB) against two strains of S. frugiperda (J.E. Smith). The Philippine EPN isolates were shown to be pathogenic to S. frugiperda regardless of FAW strains. Among the three isolates under the genus Heterorhabditids, HiPBCB was the most virulent among the test isolates tested against two strains of FAW. The result showed a high significance on the pathogenicity test exposed to all isolates at 24 hpi. The highest LC50 was observed for SaMBLB, corresponding to 36.95 IJs/larva (CS) and 35.92 IJs/larva (RS). This was sufficient to achieve 100% mortality after 48 hrs significantly differed from the three H. indica. On the lethal time (LT50) estimates, infection with H. indica in both strains had no significant differences due to the overlapping fiducial limits. However, both strains had significantly longer lethal times (LT50) when infected with S. abbasi (MBLB). No intraspecific variability was observed in the virulence of the different H. indica isolates. More apparent is the interspecific variability between S. abbasi and H. indica, as the latter exhibited higher virulence activity. This study revealed no pathogenicity variations in strains of S. frugiperda. However, it showed a different level of virulence, LC50, and LT50 between H. indica and S. abbasi.
Adaptation and Validation of the Greek Version of a Short-Form Oral Health Impact Profile and Psychosocial Impact of Dental Aesthetics Questionnaire: The OHIP-14-Gr and PIDAQ-Gr
Authors: Balti Anthoula Spiridoula , Möltner Andreas , Rüttermann Stefan , Gerhardt-Szép Susanne , Giraki Maria
Published: October 2023

Background:Oral health-related quality of life (OHRQoL) is recognized as a significant aspect of health outcomes. The Oral Health Impact Profile (OHIP-14) and the Psychosocial Impact Dental Aesthetics Questionnaire (PIDAQ) are valid instruments that capture different facets of OHRQoL. The OHIP-14 focuseson the effects of oral disorders, whereas the PIDAQ emphasizes the impacts of dental aesthetics on quality of life. The intention of this study was to adapt the OHIP-14 and PIDAQ in a Greek cultural context and to investigate their psychometric properties in all age groups of adults.
Methods:The original English OHIP-14 and PIDAQ questionnaires were translated into Greek, cross-culturally adapted according to the forward-backward technique, pretested, and applied to a validation sample of 280 participants aged 18-79 in dental practice. In total, 59 participants in thevalidation set underwent the procedure after 12 weeks. Internal consistency and reproducibility established reliability. Content, construct, and convergent validity were supported. The questionnaires were also contrasted with sociodemographic variables (age, gender, education, residence).
Discussion:Cronbach´s alpha was 0.94 for the OHIP-14-Gr and 0.95 for the PIDAQ-Gr. Correcteditem-total correlation coefficients ranged from 0.45 to 0.81 for the OHIP-14-Gr and from 0.53 to 0.82 for the PIDAQ-Gr. Average interitemcorrelation coefficients were 0.52 (OHIP-14-Gr) and 0.48 (PIDAQ-Gr). Interclass correlation coefficient(ICC) was 0.73 for theOHIP-14-Gr and 0.86 for the PIDAQ-Gr. Factor analysis with target rotation confirmed the four-dimensional factor structure of the PIDAQ-Gr. Item factor loadings varied between 0.38 and 1.09. Pearson`s correlation coefficients between the subscales and the total scores of the OHIP-14-Gr and PIDAQ-Gr ranged from 0.29 to 0.67,resulting in highly significant correlations for the total scores and subscales of the Greek questionnaires (p < 0.001).
The results attribute good to excellent psychometric properties to the Greek versionsof the PIDAQ and OHIP-14. They indicate reliable and valid tools for the standardized assessment of the psychosocial impact of oral disorders and dental aesthetics among adults. The present study extends the use of these questionnaires to includethe important target group of young adults.
RETRACTED: “Visualization matters” – Stereoscopic visualization of 3D graphic neuroanatomic models through AnaVu enhances basic recall and radiologic anatomy learning when compared with monoscopy
Authors: Yohannan Doris George , Oommen Aswathy Maria , Kumar Amruth S , Devanand S , Resivi Minha , Sajan Navya , Thomas Neha Elizabeth , Anzer Nasreen , Raju Nithin Kadakampallill , Thomas Bejoy , Rajan Jayadevan Enakshy , Govindapillai Umesan Kannavilakom , Harish Pawan , Kapilamoorthy Tirur Raman , Kesavadas Chandrasekharan , Sivaswamy Jayanthi
Published: October 2023

The authors have requested that this preprint be removed from Research Square.
A Novel HOIP Frameshift Variant Alleviates NF-kappaB Signaling and Sensitizes Cells to TNF-induced Death
Authors: Tu Xin , Wang Mengru , Bai Ying , Jiang Dan , Wang Yue , Zhou Yingchao , Zhou Mengchen , Chen Yilin , Yu Chenguang , Wang Xiangyi , Guo Qiang , Zha Lingfeng , Li Qianqian , Cao Zhubing , Wu Jianfei , Shi Shumei , Wang Qing , Xu Chengqi , Kong Xiangdong
Published: October 2023

The linear ubiquitin chain assembly complex (LUBAC) is the sole known complex that can assemble linear ubiquitin chains. It is composed of three distinct subunits: HOIP, SHARPIN, and HOIL-1L, and has a wide range of tissue expression patterns. HOIP, the key component of LUBAC, possesses the capability to form linear ubiquitin linkages. In this study, we report a novel homozygous deletion variant of HOIP that leads to the loss of the catalytic domain of HOIP. The truncated protein could still interact with the other two proteins but was unable to create linear chains. Cells transfected with the truncated protein demonstrated impaired NF-κB activation and MAPK signaling when compared to wild-type cells, as well as sensitivity to TNF-induced death, including apoptosis, necroptosis, and pyroptotic forms of death. This finding provides insight into the genetic range of linear ubiquitination deficiencies in humans and suggests the involvement of cell death in disease pathogenesis.
Effective Kirschner wire fixation for tissue necrosis of open comminuted tibial plateau fracture: A case report and literature review
Authors: Wang Zeyong , Yang Fei , Zhu Yiran , Qin Jian , Yuan Tangbo
Published: October 2023

Background:As a part of the knee joint, the tibial plateau plays a very important role in the weight-bearing function of the knee joint. Tibial plateau fracture is usually caused by severe violent injury. Clinical treatment is mainly to reconstruct the structure of tibial plateau and restore the function of knee joint. The main surgical treatments include traditional open reduction and internal fixation, external fixation, and arthroscopy-assisted minimally invasive techniques, depending on the extent of the tibial plateau fracture and the tissue condition of the wound. For patients with open comminuted tibial plateau fracture with poor tissue condition and not suitable for internal and external fixation, the fixation of Kirschner wires can be used as an option for temporary reconstruction of the tibial plateau structure, which is conducive to the early functional exercise of patients, and is an alternative solution.Case presentation:We present the case of a 72-year-old female patient with an open comminuted tibial plateau fracture who sufferd a severe violent traffic accident injury with tissue necrosis around the wound. We performed autologous skin flap to transplant necrotic skin and used Kirschner wires to temporarily fix the tibial plateau. One year postoperatively, the patient's knee function recovered well without traumatic osteoarthritis.Conclusion：Temporary fixation of the Kirschner wires combined with autologous flap transplantation can provide effective support and restore necrotic skin function for open comminuted fractures with poor wound tissue condition that is not suitable for internal and external fixation therapy.
Clinical and genetic characteristics of CYP2U1-associated hereditary spastic paraplegia in three children from China
Authors: Guo Liqi , Jiang Wei , Lu Guanting , Zhong Min
Published: October 2023

Background and objective
Hereditary spastic paraplegia (HSP) type 56 (SPG56), caused by mutations in CYP2U1, is a rare type of HSP with an autosomal recessive (AR) mode of inheritance. The onset of SPG56 usually occurs early and displays complex symptoms. To date, less than 27 variants have been reported from 25 families across different countries and regions worldwide. This study is the first to describe the clinical manifestations, imaging characteristics, and mutated CYP2U1 loci in 3 children from China.
Methods
CYP2U1 mutations were identified by Trio-WES of the samples obtained from the children clinically diagnosed with HSP. Subsequently, we summarized the clinical presentation, imaging features, and family history and further compared with previously reported cases.
Results
Five novel mutations, namely, c.1032T>A, c.179C>G, c.570(exon2)delG, c.470(exon1)delC, and c.1526A>C(E5), were identified. Two patients carried compound heterozygous mutations derived from their parents with heterozygous mutations. The third child harbored a homozygous mutation, inherited from his parents. Disease onset was infantile in all the patients. Two patients developed motor regression and one displayed an abnormal gait. The patients exhibited varying degrees of delay in cognitive/language development, active tendon reflexes, positive ankle clonus, and increased muscle tone. Cranial and spinal cord magnetic resonance imaging (MRI) revealed abnormalities in all the patients.
Conclusions
This study identified five novel variants in the three patients, and expanded the clinical and molecular spectrum of SPG56. The identified mutant loci were relatively conserved across several species, and the findings provide a basis for subsequent functional validation.
ChatGPT Demonstrates Potential for Identifying Psychiatric Disorders: Application to Childbirth-Related Post-Traumatic Stress Disorder
Authors: Bartal Alon , Jagodnik Kathleen , Chan Sabrina , Dekel Sharon
Published: October 2023

Free-text analysis using Machine Learning (ML)-based Natural Language Processing (NLP) shows promise for diagnosing psychiatric conditions. Chat Generative Pre-trained Transformer (ChatGPT) has demonstrated initial feasibility for this purpose; however, this work remains preliminary, and whether it can accurately assess mental illness remains to be determined. This study examines ChatGPT’s utility to identify post-traumatic stress disorder following childbirth (CB-PTSD), a maternal postpartum mental illness affecting millions of women annually, with no standard screening protocol. We explore ChatGPT’s potential to screen for CB-PTSD by analyzing maternal childbirth narratives as the sole data source. By developing an ML model that utilizes ChatGPT’s knowledge, we identify CB-PTSD via narrative classification. Our model outperformed (F1 score: 0.82) ChatGPT and six previously published large language models (LLMs) trained on mental health or clinical domains data, suggesting that ChatGPT can be harnessed to identify CB-PTSD. Our modeling approach can be generalized to assess other mental health disorders.
A Dental Bleaching Survey on Two Bleaching Systems and Their Effect on Nitric Oxide and Catalase Enzyme in the Gingival Crevicular Fluid
Authors: Wakeel Aliaa Mohamed el , Baz Maha Abdel Salam El , Fadel Mona Mohamed , Moneim Ahmed Esmat Abdel , Aref Ahmed Mostafa , Refai Ibrahim Mahmoud El
Published: October 2023

Objective:
This study was carried out to examine the effect of two in-office bleaching systems by measuring the level of catalase enzyme (CAT) and nitric oxide (NO) in the gingival fluid (GCF) before and after bleaching. In addition, each participant was asked to fill out an online survey to examine their satisfaction with the bleaching procedure.
Materials and Methods:
Thirty-six healthy young participants were selected. They were divided into two groups according to the bleaching system used; Philips Zoom White of 25% H2O2 or Fläsh White Smile of 32% H2O2. Three sessions, 15 minutes each were performed in the same visit for each participant. The (GCF) samples were collected using a sterile periopaper before and after the bleaching session. A survey link was sent to all participants to examine their satisfaction.
Results:
There was a statistically significant increase in (CAT) and (NO) in the (GCF) of the Fläsh group when compared to the Zoom group. Participants reported 94% satisfaction with both bleaching systems. There was no statistically significant difference between the Fläsh and Zoom groups in all participant's answers except in the degree of gingival pain where the number of participants who reported no or mild pain in the Fläsh were greater than those in the Zoom.
Conclusion:
The higher percentage of H2O2 in Fläsh group resulted in the increase of (CAT) and (NO) release in the (GCF). Participants in both groups were equally satisfied.
Clinical relevance:
Risks from dental materials have to be evaluated to prevent endangering human health.
Analysis of Immune-Related and Angiogenesis-Related Genes in Hepatocellular Carcinoma: Implications for Prognosis and Drug Sensitivity
Authors: wang peng , zhao haoran , liu chunxun , zhang yubao
Published: October 2023

In this study, we conducted a comprehensive analysis of immune-related and angiogenesis-related genes (IRAR DEGs) in hepatocellular carcinoma (HCC). We utilized data from the TCGA-LIHC project and performed expression difference and correlation analysis, clinical prognosis analysis, enrichment analysis, correlation analysis with immune cell infiltration, construction of advanced prognostic models, and evaluation of drug sensitivity. Our findings revealed 18 IRAR DEGs associated with both immune response and angiogenesis in HCC. We identified significant expression differences and correlations among these genes. Additionally, we demonstrated their clinical relevance in terms of tumor stage, survival prognosis, and immune cell infiltration. Furthermore, we performed functional enrichment analysis and identified enriched pathways and biological processes. Our study provides valuable insights into the molecular mechanisms and clinical implications of IRAR DEGs in HCC, which may contribute to the development of targeted therapies and precision medicine approaches for HCC patients.
Impact of center volume on in-hospital mortality in adult patients with out‑of‑hospital cardiac arrest resuscitated using extracorporeal cardiopulmonary resuscitation: A secondary analysis of the SAVE-J II study
Authors: Misumi Kayo , Hagiwara Yoshihiro , Kimura Takuya , Hifumi Toru , Inoue Akihiko , Sakamoto Tetsuya , Kuroda Yasuhiro , Ogura Takayuki
Published: October 2023

Background:Recently, patients with out-of-hospital cardiac arrest (OHCA) refractory to conventional resuscitation have started undergoing extracorporeal cardiopulmonary resuscitation (ECPR). However, the mortality rate of these patients remains high. This study aimed to clarify whether a center ECPR volume was associated with the survival rates of adult patients with OHCA resuscitated using ECPR.
Methods: This was a secondary analysis of a retrospective multicenter registry study, the SAVE-J II study, involving 36 participating institutions in Japan. The centers were divided into three groups according to the tertiles of the annual average number of patients undergoing ECPR: high-volume (≥21 sessions per year), medium-volume (11–20 sessions per year), or low-volume (<11 sessions per year). The primary outcome was survival rate at the time of discharge. Patient characteristics and outcomes were compared among the three groups. Moreover, a multivariable-adjusted logistic regression model was applied to study the impact of center ECPR volume.
Results: A total of 1,740 patients were included in this study. The center ECPR volume was strongly associated with survival rate at the time of discharge; furthermore, survival rate was best in high-volume compared with medium- and low-volume centers (33.4%, 24.1%, and 26.8%, respectively; P=0.001). After adjusting for patient characteristics, undergoing ECPR at high-volume centers was associated with an increased likelihood of survival compared to middle- (adjusted odds ratio 0.657; P=0.003) and low-volume centers (adjusted odds ratio 0.983; P=0.006).
Conclusion: The annual number of ECPR sessions was associated with favorable survival rates and lower complication rates of the ECPR procedure.
IRB information: The present study was approved by the institutional review board of Kagawa
University (approval number: 2018-110)
Clinical trial registration: https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000041577 (unique identifier: UMIN000036490, Registered 15 April 2019, retrospectively registered)