bluuebunny/crossref_metadata_2025 huggingface dataset:
MEDICINAL PLANTS AS A GENERATIVE THEME FOR THE STUDY OF ORGANIC FUNCTIONS AND SCIENTIFIC LITERACY IN CHEMISTRY
Authors: Cruz Jaine Costa , de Freitas Rita de Cássia Ramos Queiroz , Queiroz Maria Sandra Ramos , Neves Luís Henrique Pereira , de Souza Cassius , de Castro Symone Costa , Souza Junior Ivanilson Vieira , Santana Jane Geralda Ferreira
Published: September 2024

Chemistry teaching requires the use of approaches that provide students with conditions so that they can critically interpret the reality in which they live. This implies the need to link the content worked with the social context in which the student is inserted. However, the practice of contextualizing is rarely addressed in the classroom, especially when it comes to teaching Organic Chemistry. Therefore, this research aimed to propose a didactic intervention based on the theme of medicinal plants as a proposal to integrate the student's daily life with the construction of knowledge about Organic Functions, in order to make the teaching and learning process more meaningful in accordance with the proposal for Scientific Literacy. The research was carried out with students from a 3rd year class of Integrated Technical High School in Computer Science for the Internet at the Federal Institute of Education Science and Technology Baiano - Campus Guanambi, in the period between November 2022 and May 2023 and involved six stages, with diverse activities. The use of the theme met the objectives of the study proposal, as, depending on the receptivity of the participants, it constitutes a teaching resource that brought the study of Organic Functions closer to everyday life, favoring more meaningful learning. The proposed use of the generating theme also demonstrated that it aroused the students' curiosity and interest, given their active participation in the construction of knowledge, which may have contributed to the teaching and scientific literacy processes.
READ, CHILD! LITERARY READING AND DIVERSITY
Authors: Teixeira Nincia Cecilia Ribas Borges
Published: September 2024

The project Leia, criança! promoted actions and reflections that valued diversity and respect for differences through literature. Historically, the school has difficulties in dealing with diversity and in this gap social projects that prioritize literary reading can promote discussion about differences. The project discussed themes historically invisible in the school context while fighting for the promotion of full citizenship through educational practices. Their approaches positioned the school in the direct fight against gender, ethnic-racial, economic-social discrimination, recognizing that such practices represent dilemmas that need to be denaturalized and overcome in social relations, because they foster hatred, intolerance of differences and, above all, make people unequal in the school environment. The target audience was students from the 6th grade of Elementary School in the public network of the city of Guarapuava-PR.
DOENÇA DE ALZHEIMER: PERSPECTIVA DE CUIDADORES FAMILIARES DIANTE DO CUIDADO DOMICILIAR VIVENCIADOS DURANTE A PANDEMIA DE COVID-19
Authors: Lima Geovana da Silva , Nunes Daniela Aparecida de Souza , Stevanato Kely Paviani , de Souza Rebeca Rosa
Published: September 2024

Objetivo: compreender como cuidadores familiares do idoso com doença de Alzheimer vivenciaram o cuidado domiciliar durante a pandemia de COVID-19. Metodologia Pesquisa exploratória, descritiva de cunho qualitativo realizada junto a cuidadores familiares de idosos diagnosticados com doença de Alzheimer em um município na região Noroeste do Paraná, Brasil. As entrevistas foram realizadas por meio de visitas domiciliares mediadas pelos Agentes Comunitários de Saúde, o participante foi convidado a responder o questionário de caracterização demográfica e com sua autorização a entrevista face a face foi gravada. Posteriormente, foram transcritas e organizadas no software MAXQDA Plus 2020 e análise pelo referencial metodológico de Bardin. Resultados: Participaram desse estudo 12 cuidadores familiares de idosos com doença de Alzheimer, os dados evidenciaram que o processo de cuidar seja em tempos normais ou em períodos pandêmicos gera sobrecarga física e emocional em especial quando este é único cuidador responsável. Sobrecarga decorrente da mudança de rotina, falta de liberdade e vida social, o que pode influenciar qualidade de vida do cuidador. Conclusão: deslumbra-se a necessidade de implementação de rede de apoio profissional e disseminação de informação sobre cuidado domiciliar a idosos com doença de Alzheimer e/ou outras demências. Oferecer suporte profissional, pessoal e emocional contribui não somente com a qualidade do cuidado recebido pelo idoso, mas também com a redução de riscos de adoecimento físico e mental por parte do cuidador familiar.
Manual Integral de Gastroenterología Vol 2
Authors: Díaz Yaguachi Fabricio Miguel
Published: September 2024

El Manual Integral de Gastroenterología Vol 2 continúa su enfoque en brindar un conocimiento exhaustivo y actualizado sobre las patologías del sistema digestivo. Este volumen profundiza en el diagnóstico y tratamiento de afecciones más complejas, abordando temas como enfermedades hepáticas crónicas, trastornos funcionales y emergentes en el tracto gastrointestinal. A través de una estructura clara y casos clínicos prácticos, el manual se convierte en una herramienta indispensable para gastroenterólogos y otros profesionales de la salud que buscan perfeccionar sus habilidades y ofrecer un cuidado integral a sus pacientes
Manual de Dermatología Clínica: Diagnóstico y Tratamiento Tomo 3
Authors: Suntaxi Navarrete Susana Alejandra
Published: September 2024

l Manual de Dermatología Clínica: Diagnóstico y Tratamiento Tomo 3 ofrece una revisión detallada de las últimas técnicas diagnósticas y tratamientos en el campo de la dermatología. Este tomo se enfoca en trastornos dermatológicos complejos y emergentes, ofreciendo estrategias terapéuticas basadas en la evidencia y casos clínicos que ilustran el manejo práctico de enfermedades cutáneas. Ideal tanto para dermatólogos experimentados como para médicos en formación, esta obra constituye una referencia esencial para optimizar la atención dermatológica y enfrentar los desafíos del diagnóstico diferencial en la práctica clínica diaria.
Compendio de Anestesiología Vol. 2
Authors: Cueva Torres Ericka Andrea , Robles Aguilar María Daniela
Published: September 2024

El Compendio de Anestesiología Vol. 2 continúa proporcionando una revisión exhaustiva de los aspectos clave en la práctica anestésica. Este volumen está dedicado a técnicas avanzadas de manejo anestésico en cirugías de alta complejidad, abordando tanto la anestesia general como regional. Con una orientación práctica y basada en la evidencia, este compendio incluye protocolos actualizados, estudios de caso y un análisis detallado de complicaciones intraoperatorias. Es una herramienta indispensable para anestesiólogos, residentes y profesionales de la salud interesados en perfeccionar sus habilidades en el manejo del paciente quirúrgico, garantizando su seguridad y bienestar en todo momento
Manual de Dermatología Clínica: Diagnóstico y Tratamiento Tomo 4
Authors: Ramos Basante Daniela Alejandra , Toapanta Llumiquinga Paúl Alexander
Published: September 2024

El Manual de Dermatología Clínica: Diagnóstico y Tratamiento, Tomo 4, ofrece una revisión exhaustiva de las técnicas diagnósticas y tratamientos más recientes en el campo de la dermatología. Esta edición se centra en trastornos dermatológicos complejos y emergentes, presentando estrategias terapéuticas basadas en la evidencia, junto con casos clínicos que ilustran el manejo práctico de diversas enfermedades cutáneas. Es una referencia indispensable tanto para dermatólogos experimentados como para médicos en formación, proporcionando herramientas clave para optimizar la atención dermatológica y enfrentar los retos del diagnóstico diferencial en la práctica clínica diaria.
ՀԱՅԱՍՏԱՆԻ ԱՆՁՆԱՎՈՐՈՒՄԸ ՊԱՐԹԵՎԱԿԱՆ ՀԱՂԹԱԿԱՄԱՐԻ ՎՐԱ՝ ԸՍՏ ՕԳՈՍՏՈՍ ԿԱՅՍԵՐ Մ. Թ. Ա. 19 – 16 ԹԹ. ՀԱՂԹԱԴՐԱՄՆԵՐԻ (ՌՈՒՍ.) / PERSONIFICATION OF ARMENIA ON THE PARTHIAN ARCH ON THE 19 – 16 BC TRIUMPHAL COINS OF AUGUSTUS
Authors: Margaryan Hasmik
Published: September 2024

On the occasion of the diplomatic victory and the Parthian-Roman negotiations on the return of prisoners of war and Roman banners in 20 BC by order of Augustus, the Parthian triumphal arch was erected in Rome, three series of gold and silver triumphal coins were minted with its image on the reverse side. On the coins of the Roman mint, owned by the senator Lucius Vinicius, a Parthian arch with a sculptural group of Augustus in a quadriga, flanked by male figures is depicted. Around the entire composition, the inscription CIVIB(US) et SIGN(IS) MILIT(ARIBUS) PART(HIS) RECUP(ERTIS) is minted in a circle. Figures personifying Parthia and Armenia hold out Roman banners to Augustus. The statue of Armenia standing on the left is presented with attributes of power-an Artaxiads tiara on its head and with a bow in its hand, which symbolize the political and state status of Armenia. The physiognomic features and iconographic characteristics in the image of the face of Armenia also reveal its ethnicity. Both figures on the lower side spans symbolize the equality of the two allies of Rome in the person of Armenia and Parthia, and their small size next to the huge statue of the emperor demonstrates the status of these countries in the hierarchical ladder of the peoples of the empire. The sculptural program of the arch has become a kind of synthesis of themes, plots and motifs embodied in the act of returning the banners.
ՀԱՅՈՑ ԹԱԳՈՒՀԻ ԷՐԱՏՈՅԻ ՄԱՍԻՆ. ՊԱՏՄԱԿԱՆ ԵՎ ԴՐԱՄԱԳԻՏԱԿԱՆ ՈՒՍՈՒՄՆԱՍԻՐՈՒԹՅՈՒՆ (ԱՆԳԼ.) / NOTE ON ERATO, QUEEN OF ARMENIA։ HISTORICAL AND NUMISMATIC STUDY
Authors: Yevadian Maxime
Published: September 2024

New numismatic discoveries have led us to take a closer look at the reign of Erato, the last Artaxiad ruler of Greater Armenia, from the direct line. We published our full demonstration on this subject in 2021 (Arakelian – Yevadian 2021); in this article, we would like to present what we know about Queen Erato, her coinage, and also present a corpus of her known coins.
Erato is an Armenian queen of the Artaxiad lineage, insofar as, on the coins Types 1 and 2, she appears with her brother Tigranes, who possesses all the attributes of the Artaxiads. Erato is undoubtedly the sister of a ruler named Tigranes, as indicated on the coins Types 1 and 2. She is probably the daughter of Artaxias II, son of Artavasdes II, see Family Tree in conclusion (Fig. 3). We believe that Erato and her brother Tigranes were not married.
With the new discovery of the coins, Types. 3 and 4, we estimate that Erato ruled three times:
(a) A first period with Tigranes, and Parthian support. The coinage Types 1 must be attributed to this first reign.
(b) A second period with the same Tigranes, and the consent of Augustus. The coin Types 2 and Type 5 must be attributed to this second reign.
(c) A third and last period, her personal reign; Erato rules alone, probably with the consent of the Romans. This reign predates the arrival of Vonones. The coins Types 3 and 4 must be attributed to this third reign.
This analysis attempts to respond to the succession of short rules illustrated by typical rules, characterizing a period of destabilization and decline.
Aprendizaje por descubrimiento una opción metodológica para estimular el razonamiento indagatorio del discente en Ciencias Naturales
Authors: Yépez Vallejo Carmen Elena , Lascano Herrera Jenny Mariela , Jaramillo Aguilar Betty Azucena , Lalangui Sarango Ricardo Geovanni
Published: September 2024

Ser artífice de cambios transformadores del proceso de enseñanza aprendizaje requiere incorporar en la praxis educativa lineamientos alternativos uno e ellos el aprendizaje por descubrimiento como metodología eficaz del desarrollo del razonamiento indagatorio en la problematización de los contenidos de la asignatura de Ciencias Naturales. No es suficiente con tener la buena voluntad es imprescindible dominar cada uno de los procesos a ser imbricados en la formación de los estudiantes enmarcado en el mejoramiento de capacidad de razonamiento indagatorio, reduciendo con ello las falencias de la educación tradicional. En el proceso investigativo participaron 31 educadores de Educación Básica que imparten la asignatura de Ciencias Naturales, quienes fueron encuestados sobre los tipos y estrategias de aprendizaje por descubrimiento y los niveles del razonamiento indagatorio. También fue necesario recurrir a la investigación descriptiva, bibliográfica y de campo, además, responde a un diseño no experimental. Entre los principales hallazgos, la mayoría de los educadores tienen falencias formativas sobre los tres tipos de aprendizaje por descubrimientos, las estrategias y los cuatro niveles de razonamiento indagatorio, un reducido número de docentes tienen un conocimiento muy genérico sobre lo auscultado, respecto a capacitación que debe ofrecer el distrito sobre lo indagado es inexistente. Los resultados evidencian que la carencia de capacitación y el conocimiento superficial del profesorado sobre lo indagado, limita que los educandos potencien su razonamiento indagatorio en función de los contenidos de la asignatura de Ciencias Naturales.
Factores asociados a la fatiga por compasión en cuidadores formales de pacientes crónicos. Una revisión sistemática
Authors: Calva Camacho Evelin Astrid
Published: September 2024

La fatiga por compasión (FC), también denominada desgaste por empatía, es una forma de malestar que afecta a quienes están expuestos de manera prolongada al sufrimiento de otras personas. Este fenómeno ha sido ampliamente estudiado en el ámbito de los profesionales de la salud, debido a que su contacto constante con el dolor y la angustia de los pacientes los hace especialmente vulnerables, generando en ellos síntomas tanto emocionales como sociales. Por lo tanto, el objetivo de esta revisión fue identificar los factores que contribuyen a la fatiga por compasión en cuidadores formales de pacientes crónicos. Por cuanto, la búsqueda de artículos se realizó en tres bases de datos en inglés y español: Scopus, ScienceDirect y PubMed, en donde se seleccionaron artículos publicados entre los años 2019 y 2024. Como se resultado se obtuvo 14 artículos que evidenciaron que esta variable está ligada a factores como la edad, género, horas de trabajo y el estado civil, destacando el impacto de la carga laboral y las condiciones del entorno hospitalario. Por lo cual es recomendable que las instituciones de salud implementen políticas orientadas al cuidado compasivo, lo que no solo beneficiaría el bienestar de los profesionales, sino también la calidad de la atención brindada. Además, resulta fundamental que se reconsidere el peso de las tareas burocráticas y los estrictos protocolos, ya que podrían desviar a los profesionales de su misión principal como es ofrecer una atención genuinamente empática y compasiva hacia los pacientes.
CURRENT STATUS AND MEASURES TO DEVELOP CRITICAL THINKING FOR PEDAGOGICAL STUDENTS IN USING GENERATIVE ARTIFICIAL INTELLIGENCE
Authors:   1Department of Literature, Hanoi University of Education, Vietnam, Thi Hien LUONG , Phuong Nga LE ,   Department of Primary Education, Hanoi University of Education, Vietnam
Published: September 2024

From the results of a survey of students at universities in Vietnam on the use of generative artificial intelligence (Gen AI), the paper proposes three groups of measures to develop critical thinking. Students need to be aware of the benefits and potential risks of Gen AI, practice critical thinking operations such as information verification, questioning skills, comprehensive information analysis and evaluation, comparing sources, self-assessment, and decision-making. Instructors should employ active teaching methods and appropriate assessment techniques when integrating Gen AI in the classroom. Educational authorities should promptly issue codes of conduct and guidelines for the ethical and responsible use of Gen AI. Keywords: Generative artificial intelligence; critical thinking; higher education.
DESIGNING GAME AND ORGANIZING TEACHING THROUGH GAMES FOCUSED ON TEACHING INFORMATICS IN GENERAL EDUCATION
Authors:   Department of Information Technology, School of Education, Vinh University, Nghe An, Vietnam, Thi Kim Oanh TRAN , Huu Duc NGUYEN ,   Department of Information Technology, School of Education, Vinh University, Nghe An, Vietnam
Published: September 2024

To ensure that teaching approaches students' qualities and abilities, the use of a variety of active teaching methods that are appropriate to the characteristics of the subject and the age of the students is extremely important. With some outstanding characteristics of Gen Z (born from 1997 to 2012), Gen Alpha (born from 2013 to 2028), which are generations born in the era of Information Communications Technology (ICT), Internet and social networks, the use of teaching methods through games is effective. Informatics is a subject that both provides knowledge and trains thinking skills and ICT application skills. The use of teaching methods through games, especially games with ICT applications, will be very appropriate. This article aims to propose some principles in designing and organizing learning games in teaching Information Technology in general education; at the same time, develop a number of illustrative learning activities using teaching methods through games. Keywords: General Education Program 2018; qualities; competencies; learning games; information communication technology (ICT).
CULTURAL HERITAGE EDUCATION AS A CONSUMER PRODUCT IN THE AGE OF CULTURAL INDUSTRIES, THE CASE OF THEN TAY HERITAGE IN LANG SON
Authors:   Lang Son Provincial Party Committee Organizing Committee, Vietnam, The Anh DANG ,   Hanoi National University of Education, Vietnam
Published: September 2024

In an era of globalization and cultural integration, cultural heritage plays a crucial role in preserving and promoting the cultural diversity of communities worldwide. This article explores the Then Tay cultural heritage in Lang Son, an ethnic cultural resource with the potential to create valuable consumer products in the age of cultural industries, particularly when viewed from the perspective of heritage education. The research methodology involves a comprehensive review of relevant literature to examine the heritage, the role of heritage education in conserving, developing, and promoting it as a consumer product in today's cultural industrial age. The proposed educational strategies outlined in this article aim to both enhance the exploration and understanding of the heritage while creating consumer products that are relevant to the modern era, honoring and preserving the precious cultural values of the Tay community in high school. This approach seeks to help the heritage adapt and thrive in the challenging context of the cultural industrial age. Keywords: Cultural heritage; heritage education; cultural industries; consumer products; Then Tay heritage; Lang Son.
DEVELOPING STUDENTS’ CAREER ORIENTATION COMPETENCE THROUGH THE E-STEM LESSON “THE COMPANY DESIGNS SENSOR APPLICATION PRODUCTS” IN TEACHING TOPIC “INTRODUCTION TO ELECTRONICS”
Authors:   Ho Chi Minh City University of Education, Vietnam, Minh Hoa QUAN , Thi Phu Khanh NGUYEN ,   Tan Phuoc Khanh High School, Binh Duong, Vietnam, Kien Quan LY ,   Tan Phuoc Khanh High School, Binh Duong, Vietnam, Thi Thu Huong LE ,   Tan Phuoc Khanh High School, Binh Duong, Vietnam
Published: September 2024

Based on the E-STEM theoretical framework, STEM lessons, and thematic knowledge content “Introduction to Electronics” in the 11th grade physics curriculum, the article designs the E-STEM lesson “The company designs sensor application products” to foster students’ career-oriented capabilities. Experimental results show that the lesson has an impact on the development of career-oriented competency, including STEM career awareness, STEM self-efficacy, and STEM career interest. Furthermore, although the personal emotional aspect and the decision to choose a STEM career also had an increased average score after the experimental process, it was not statistically significant. In general, students can complete tasks and respond positively to the lessons, while also having the opportunity to foster behavioral manifestations of career-oriented and physics competency. These contributions will suggest and direct the integration of E-STEM into forms of implementing STEM education in high schools in the future. Keywords: E-STEM; STEM education; entrepreneurship education; career orientation; Physics curriculum.
ENHANCING STUDENTS' MOTIVATION FOR MATHEMATICS THROUGH A COOPERATIVE LEARNING APPROACH
Authors:   Institute of Technical Education, HCMC University of Technical Education, Vietnam, Ngoc Trung DANG , Van Hong BUI ,   Institute of Technical Education, HCMC University of Technical Education, Vietnam
Published: September 2024

Improving student motivation is considered one of the important strategies to create educational effectiveness, especially with mathematics education. This study was conducted with the aim of improving students’ motivation towards a collaborative learning approach. To achieve the above goal, we organized an 8-week controlled experimental study for 8th grade students at a secondary school in Ho Chi Minh City, in which the experimental group learned according to the STAD cooperative learning model. The research results showed that the motivation of students in the experimental group increased statistically significantly compared to the control group. In other words, teaching mathematics using the cooperative learning method has increased learners’ motivation. Keywords: Learning motivation; cooperative learning; improving learning motivation; STAD model.
FACTORS INFLUENCING MATHEMATICAL LANGUAGE EDUCATION FOR PRESCHOOL CHILDREN
Authors:   University of Education, Vietnam National University, Vietnam, Thuy Tien LE
Published: September 2024

Language is one of the essential factors in the formation of mathematical understanding in preschool children. Mathematical language education equips children with tools that not only support the cognitive process and discovery of the world but also build a foundation for the development of thinking and the refinement of the language skills of everyone. The research question: “What factors affect the process of mathematical language education for preschool children?” provides a basis to guide teachers in planning appropriate activities that suit the characteristics of children as well as other conditions. Based on a comprehensive literature analysis, the study identifies the factors affecting the mathematical language education process for preschool children, which are classified into two groups: subjective factors and objective factors. The research result provides an important foundation to propose specific measures to improve the quality of education for children in kindergartens. Keywords: Language; mathematical language; preschool children.
DIGITAL TRANSFORMATION IN HIGH SCHOOL EDUCATION: EXPLOITING DIGITAL PLATFORMS, DIGITAL DATA AND DIGITAL TOOLS
Authors:   Vietnam Academy for Ethnic Minorities, Hanoi, Vietnam, Trung TRAN , Thi Phuong Thao TRINH ,   Thai Nguyen University of Education, Thai Nguyen, Vietnam, Ngoc Giang NGUYEN ,   Ho Chi Minh University of Banking, Ho Chi Minh City, Vietnam, Manh Tuan KIM ,   VNU University of Education, Vietnam National University, Hanoi, Vietnam, Thi Mai HOANG ,   Ha Noi Metropolitan University, Ha Noi, Vietnam
Published: September 2024

Digital technology in education includes artificial intelligence, Internet of Things, cloud computing, etc. contributes to transforming teaching methods from traditional to digital environment. This article presents the levels and characteristics of digital technology in education according to the ecosystem approach in general education in Vietnam. Based on this structure, digital technology ensures convenient, rich access to digital transformation, open connection, increased collaboration, and high automation in education, helping educational institutions, administrators, teachers, and students adapt to rapidly developing and sustainable digital technologies. Keywords: Digital transformation; digital technology; digital platform; digital data; high school education.
DEVELOPING A RUBRIC FOR EVALUATING STEM LESSON PLANS OF TEACHERS AND PRE-SERVICE TEACHERS
Authors:   Hanoi University of Education, Hanoi, Vietnam, Van Bien NGUYEN , Thi Thu Thuy NGUYEN ,   Pham Van Dong University, Quang Ngai, Vietnam, Thi To Khuyen NGUYEN ,   Hanoi University of Education, Hanoi, Vietnam
Published: September 2024

The paper focuses on the development and evaluation of rubric used to assess STEM lesson plans. The rubric was constructed based on theoretical studies on STEM education and decision tree models to ensure objectivity and scientific rigor. Two experts in the field of STEM education independently used the rubric for assessment, and Cohen’s Kappa coefficient was calculated to check the inter-rater reliability (k=0.625), indicating a high level of agreement. The study also analyzed STEM lesson plans of teachers and preservice teachers to identify the strengths and weaknesses of each plan. The results showed that the STEM lesson plans met the requirements of the guideline documents. Pre-service teachers’ lesson plans exhibited several strengths in terms of lesson plan ideas and the construction of inquiry-based activities, while teachers faced difficulties in identifying ideas and problem posing. Keywords: Rubric; STEM education; dicision tree; lesson plan; teacher.
Chrysin-Mediated Promotion of Odontoblastic Differentia- tion: A Pathway Towards Dental Pulp Regeneration
Authors: Lafta Ali Hussein , Al-Kariti Wurood , Yousif Bilal Akish , Ahmed Eman Mohammed
Published: September 2024

Dental pulp, a critical component in tooth development and maintenance, plays a vital role in dentin formation, nutrient supply, and signal transmission. When damaged, pulp can become infected and necrotic, leading to pain and a decline in the quality of life. Current clinical treatments, such as root canal therapy, though effective, result in the loss of pulp vitality and associated sensory and defensive functions. Recognizing the potential of regenerative approaches, our study explored the odontogenic differentiation effects of Chrysin, a natural flavonoid, on human dental pulp cells (hDPCs). Our investigations revealed that Chrysin, particularly at a concentration of 10 μM, exhibited no cytotoxic effects on hDPCs over a 5-day period. Notably, this concentration demonstrated optimal effects on alkaline phosphatase (ALP) activity and mineralization capacity, indicating its potential as an agent for odontogenic differentiation. Further analyses at the molecular level confirmed increased expression of odontogenic markers, including dentin matrix protein 1 (DMP-1), dentin sialophosphoprotein (DSPP), and ALP, supporting the pro-odontogenic effects of chrysin. In conclusion, our study underscores the positive effects of Chrysin on odontogenic differentiation in hDPCs, offering a promising avenue for further exploration in dental regenerative medicine. Future research should delve into in vivo applications and clinical assessments to validate the translational impact of Chrysin in preserving the vital pulp and advancing dental tissue regeneration.
The Effect of FSH and Letrozole Treatment on The Lipid Profile in Women Being Treated for Fertility
Authors: Humaidan Rana , Farhan Buthainah
Published: September 2024

Background: Letrozole, an aromatase inhibitor, affects the ovaries, breasts, adipose tissue, and bone by preventing androgen-to-estrogen conversion. This drastically reduces estrogen’s effects. Estrogens regulate fat metabolism by influencing lipid and lipoprotein metabolism. FSH stimulation, which induces ovulation in non-pregnant women, may help pituitary dysfunction. Regulated ovarian hyperstimulation stimulation increases follicles during in vitro fertilization. Background: Letrozole, an aromatase inhibitor, affects the ovaries, breasts, adipose tissue, and bone by preventing androgen-to-estrogen conversion. This drastically reduces estrogen’s effects. Estrogens regulate fat metabolism by influencing lipid and lipoprotein metabolism. FSH stimulation, which induces ovulation in non-pregnant women, may help pituitary dysfunction. Regulated ovarian hyperstimulation stimulation increases follicles during in vitro fertilization. The aim: To assess the difference in the level of fat (total cholesterol, triglycerides levels, HDL, LDL, and VLDL) of infertility treatment among the three study groups, the group that received HSF, the group that took Letrozole, and the control group. Methods: From October 2022 to May 2023, research was carried out. It featured 120 women who were split into three groups: those who took Letrozole consistently for a month or more in a row, those who received FSH injections continuously for a month or more in a row, and the control group who did not take any medications to promote ovulation. Results: The results show increased levels of total cholesterol, triglycerides, LDL cholesterol, and VLDL cholesterol in LET compared with other groups FSH and control. Our study showed a significant difference (p-value < 0.0001) in the concentrations of TG compared to all studied groups, when the results show decreased levels of HDL cholesterol in LET compared with other groups FSH and control, a significant difference is showed (p-value <0.0001) in the concentrations of HDL cholesterol compared to all studied groups. Conclusion: Letrozole and FSH has modulated lipid profile via increasing triglyceride, cholesterol, HDL, LDL, and VLDL, with greater impact achieved by FSH and letrozole
Nanocellulose in Drug Delivery Systems: A Comprehensive Review
Authors: Tahseen Sarah , Zidan Hiba , Manar Abdul Jabbar , Al-hassan Ahmed
Published: September 2024

Research in medicinal chemistry lays a substantial emphasis on the development of efficient drug delivery techniques that make use of nanomaterials that are both biocompatible and inert. In comparison to the numerous primary materials that are now accessible, nanocrystalline cellulose stands out due to its biocompatibility and inert qualities. The surface of the object may also be modified using a wide range of various manufacturing processes. During the course of our investigation, we have gathered data on a number of different types of nanocellulose as well as the applications of nanocellulose that are associated with drug delivery systems. Throughout the course of this investigation, the key subjects of discussion include the methods of manufacturing nanocellulose as well as its applications in oral, transdermal, and localised drug delivery systems. Furthermore, it analyses the possibilities and restrictions that are given by nanocellulose that has been surface-modified.Because of their low cost, the fact that they may be reused, and the fact that they are biodegradable, natural polymers have been the subject of recent years’ worth of substantial developments in the exploration of diverse uses.
Mechanical, Mineralogical and Durability Properties of Pulverized Pond Ash Based Concrete
Authors: KANDASAMY Yuvaraj , KUMARASAMY Vidhya , THIRUMOORTHY Pradeep , MURUGAN Sakthivel , SUBRAMANI Ramesh
Published: September 2024

In recent decades, cement production and demand have significantly impacted the environment; enormous amounts of energy are required to produce cement. This led to a severe energy crisis in our country. In order to minimize the usage of cement and energy consumption in an eco-friendly manner, industrial waste materials with cementitious characteristics are drawn to attention. Hence, the study deals with the use of pulverized pond ash as a partial replacement for cement in concrete. The mix design was carried out for M 25 grade concrete by IS 10262-2019. Two significant mix proportions were prepared, namely, Conventional Concrete (CC) (100 % cement), and Pulverized Pond Ash Concrete (PPAC) (90 % cement and 10% pulverized pond ash). In this study, cylinder compressive strength, mineralogical analysis, sulphate resistance tests, sorptivity, and water absorption, were examined. The PPAC mix outperformed CC in compressive strength by 10.74 %, 13.09 %, and 13.66 % at 28, 56, and 90 days, respectively. At 28 days, ettringite peaks are minor, with both intensity and quantity increasing significantly by 56 and 90 days. The PPAC also showed higher residual compressive strength (1.08 %, 1.65 %, 2.32 %) and lower sorptivity (8.93 %, 10.14 %, 12.5 %) than CC at all ages. From the results, PPAC showed superior properties than CC at all ages suggesting for replacement of 10 % of cement with pond ash.
An Investigation of the Pediatric Rigid Bronchoscopy Complication with three Different Anesthesia Regimes
Authors: Chavoshi Tahereh , Rokhtabnak Faranak , Nouri Nasrin , Mojaveraghili Seyedbabak , Eshghi Alireza , Salehi Reza
Published: September 2024

Background: Foreign body aspiration is common in children and poses a significant risk of morbidity and mortality. Rigid bronchoscopy is the most common method for removing aspirated foreign bodies. Objectives: Anesthesiologists play a critical role in managing these procedures, aiming to find the best strategies with the fewest complications. This study aims to compare anesthesia-related complications during rigid bronchoscopy in children using muscle relaxants versus no muscle relaxants. Methods: In this clinical trial, 60 eligible children were randomly divided into three equal groups: SP: Spontaneous ventilation with sevoflurane and propofol; VA: Controlled ventilation with sevoflurane and atracurium; VR: Controlled ventilation with sevoflurane and rocuronium. At the end of anesthesia, complications such as cough, bucking, hypoxemia, laryngospasm, and bronchospasm were compared, along with the pulmonologist’s level of satisfaction, surgery duration, and total anesthesia time in the three groups. Results: The comparison between the SP, VR, and VA groups revealed the following: No significant difference was found in the incidence of cough and respiratory distress following foreign body aspiration among the three groups (P = 0.262 and P = 0.762, respectively); minimum oxygen saturation during rigid bronchoscopy differed significantly between the groups (P = 0.013); bucking during bronchoscopy was significantly more frequent in the SP group (P = 0.017); laryngospasm was significantly more common in the SP group compared to the other two groups (P = 0.004); agitation during recovery was significantly lower in the propofol (SP) group; pulmonologist satisfaction was highest in the VR group, followed by the VA group, with a significant difference compared to the SP group (P = 0.021); although the SP group experienced more frequent hypoxemia, the difference was not statistically significant; there was no significant difference in anesthesia or bronchoscopy duration across the three groups. Conclusions: The study results suggest that using muscle relaxants in rigid bronchoscopy offers several advantages, including fewer intraoperative complications such as bucking and laryngospasm. Additionally, controlled ventilation reduced the need for intravenous anesthetics and opioids, minimizing adverse effects and shortening recovery times.
Association Between Circulating Oxidized LDL Cholesterol Levels and Premature Myocardial Infarction: A Case-Control Study
Authors: Rahmanian Karamatollah , Shojaei Mohammad , Hooshmand Farhang , Sharifi Nader , Rahmanian Vahid
Published: September 2024

Background: Acute myocardial infarction (MI) occurs less frequently in younger individuals compared to older ones. The development of atherosclerotic plaque is primarily linked to oxidized low-density lipoprotein cholesterol (Ox-LDL). Objectives: This study aimed to investigate circulating Ox-LDL levels in individuals with premature MI and compare them to controls without a history of ischemic heart disease. Methods: In this case-control study, 35 patients who experienced a premature MI within 24 hours of symptom onset and met the age criteria (men ≤ 55 years and women ≤ 65 years) were recruited as cases. For comparison, 35 age and sex-matched individuals without a history of ischemic heart disease were selected as controls. Results: Analysis of circulating Ox-LDL levels revealed a significant elevation in patients with premature MI compared to controls (2.25 ± 1.78 vs. 1.04 ± 1.17 µg/dL; P = 0.002). Elevated Ox-LDL levels were associated with a 1.70-fold increased risk of premature MI compared to healthy individuals (95% CI: 1.16 - 2.49; P = 0.007). Conclusions: This study demonstrates an association between elevated Ox-LDL levels and premature MI, particularly in younger individuals. Measuring Ox-LDL levels may help predict heart attack risk, and interventions aimed at reducing these levels could potentially prevent atherosclerosis.
Pituitary Gland Morphology: A Novel Diagnostic Marker for Differentiating Growth Hormone Deficiency from Idiopathic Short Stature in Children
Authors: Ye Yong , Yang Ying , Li Wen , Gong Jie , Shao Wenwen , Yu Chengxin
Published: September 2024

Background: The primary causes of short stature (SS) are idiopathic short stature (ISS) and growth hormone deficiency (GHD). The diagnosis of GHD relies on growth hormone stimulation tests (GHSTs), while the diagnosis of ISS is achieved through exclusion. Objectives: Growth hormone (GH) and insulin-like growth factor-I are the best therapeutic drugs for treating GHD, but their suitability for ISS remains controversial. Therefore, distinguishing between these two causes of SS is crucial. Currently, the diagnosis of GHD depends on GHSTs, whereas the diagnosis of ISS is achieved through exclusion, which is an invasive process. Thus, developing a noninvasive and convenient method to differentiate between GHD and ISS would be of great importance. Patients and Methods: We enrolled patients aged 3 - 14 years who presented with SS and underwent GHSTs and pituitary gland (PG) magnetic resonance imaging (MRI) at our hospital from January 2020 to October 2022 for a cross-sectional study. A total of 205 patients were included, comprising 83 with ISS and 122 with GHD. The GHD patients were further divided into two groups based on the peak GH level in GHSTs. All patients underwent routine physical examinations, GHSTs, PG MRI, and X-rays of the left wrist. Two authors independently recorded the PG features (height, length, width, volume, pituitary stalk diameter, pituitary stalk length, and morphology). The PG morphology was categorized into three types: Convex, flat, and concave. Bone age was estimated from X-rays of the left wrist, which were reviewed by an experienced radiologist. Comparisons between the two groups were conducted using two independent samples t-tests or chi-square (χ²) tests. Results: There were no differences between the two groups regarding baseline clinical characteristics, except for the GH peak in GHSTs (P < 0.05). Pituitary stalk diameter, PG height, PG volume, and the dorsum sellae were significantly lower, while the tuberculum sellae was higher in the GHD group compared to the ISS group (all P < 0.05). The proportion of concave PG was higher, and the proportion of flat PG was lower in the GHD group (all P < 0.05). In subgroup analysis, PG height and PG volume were significantly lower in the absolute GHD (AGHD) group compared to the partial GHD (PGHD) group (all P < 0.05). Correlation analysis showed that PG height (r = 0.635, P < 0.01) and PG volume (r = 0.786, P < 0.01) were positively correlated with the GH peak level. Further analysis also demonstrated the differential diagnostic accuracy of PG height and PG volume, with high sensitivity (PG height: 66.3%; PG volume: 84.3%) and specificity (PG height: 85.2%; PG volume: 77.9%). Conclusion: pituitary gland height, PG volume, and the concave type of PG morphology may be very helpful in the differential diagnosis of GHD and ISS.
Effects of Self-Talk and Imagery on Learning of Volleyball Serve Skill in Adolescence Female Students
Authors: Nazari Shahram
Published: September 2024

Background: Previous research on psychological interventions in sports has primarily focused on elite athletes. Studies have demonstrated the effectiveness of psychological interventions, such as self-talk (ST) and imagery (IG), in improving performance and reducing anxiety in various sports. However, limited research has been conducted on the specific application of these techniques in novice female volleyball players, particularly in the early stages of their development. Objectives: To investigate the impact of psychological intervention, specifically ST and IG, on the performance and learning of service skills among novice female volleyball players in the first year of high school. Methods: A semi-experimental study was conducted with 60 adolescent female novice volleyball players. Participants were randomly assigned to four groups: ST, IG, combined ST+ IG, and a control group (physical training only). The study included pre-test, intervention (24 sessions), post-test, and a 2-week delay retention phase. Results: The results demonstrated that both IG and ST, individually or in combination, significantly improved the performance and learning of volleyball serves among the participants. The combination group exhibited the most significant improvement. Conclusions: The findings suggest that psychological interventions, incorporating ST and IG, are more effective than single-component interventions in enhancing motor learning and performance in novice female volleyball players.
Comparison of Biomechanical, Clinical Indicators, and Quality of Life in People Undergoing Hip Replacement Surgery with Anterior and Posterior Approaches
Authors: Eshaghi Namaghi Mobina Sadat , Daryabor Aliyeh , Hejazi-Shirmard Mahnaz , Qoreishy Mohammad , Jamebozorgi Aliasghar
Published: September 2024

Background: There are ongoing debates among surgeons regarding the most effective surgical method for hip replacement, with varying preferences for the anterior and posterior approaches. Both methods have demonstrated excellent long-term outcomes, with clinical differences primarily observed in the early postoperative period. Objectives: This study aimed to compare the anterior and posterior methods of hip replacement after six months of surgery in terms of biomechanical and clinical indicators, as well as quality of life. Methods: In this cross-sectional observational study, 42 patients who underwent hip replacement surgery using either the anterior (n = 22) or posterior method (n = 20) at least six months (and a maximum of 12 months) post-surgery, along with 20 healthy individuals, were evaluated. Biomechanical indices of the center of pressure (COP) were measured using a force plate during two-leg standing with eyes open and closed. Functional balance, independence, self-perception of performance, satisfaction, and quality of life were assessed using the timed up and go test (TUG), Barthel Index, Canadian Occupational Performance Measure (COPM), and the SF-36, respectively. Results: No significant differences were found between the anterior and posterior groups in terms of COP, clinical variables, and quality of life (P > 0.05). However, when compared to the control group, the anterior replacement group exhibited significantly higher COP displacement in the medial-lateral direction (P = 0.03) and COP velocity in the anterior-posterior direction (P = 0.02) during two-leg standing with eyes open. No significant differences in COP variables were observed in the posterior replacement group compared to the control group (P > 0.05). Conclusions: The findings indicate no significant differences between the anterior and posterior approaches to hip replacement in terms of biomechanical and clinical indicators, as well as quality of life after six months. Therefore, the choice of surgical method can be based on the patient's condition and the surgeon’s expertise in the respective approach.
Оптимизация проточной части микрофлюидного канала
Authors: Шишанов М.В. , Кук Х.Г. , Ерёмин В.Б.
Published: September 2024

в данной работе рассматриваются особенности оптимизации микрофлюидного канала. Микрофлюидный канал является ключевым компонентом микрореактора, его форма и особенности гидродинамического режима напрямую влияют на успешное протеканий проводимых в нём химических реакций. Микрофлюидная отрасль регулирует процессы, протекающие в малых объемах жидкостей – порядка нано литра и меньше. Она применима к различным областям, таким как микроэлектроника, фармацевтика, специальная химия и т.д. В качестве инструмента оптимизации использовали программу вычислительного моделирования Comsol Multiphysics. Она основана на методе конечных элементов, который позволяет в точности моделировать задачи гидродинамического профиля. В данной статье рассмотрена простейшая форма микроканала – канал круглого сечения размером 0.75 мм со смесительной ячейкой. Приведено математическое моделирование процесса, определён критерий оптимальности, адекватный для поставленной задачи. В качестве одного из компонентов данного критерия использовали диодность – критерий, обуславливающий способность пропускать поток в прямом направлении при условии наличия обратного потока. В результате данной работы выявлена наиболее оптимальная форма канала микрореактора, удовлетворяющая требуемым условиям процесса, получены основные гидродинамические параметры и определена зависимость диодности от используемого критерия.

n this paper, the features of microfluidic channel optimization are considered. The microfluidic channel is a key component of the microreactor, its shape and features of the hydrodynamic regime directly affect the successful course of chemical reactions carried out in it. The microfluidic industry regulates processes occurring in small volumes of liquids – on the order of a nano liter or less. It is applicable to various fields such as microelectronics, pharmaceuticals, specialty chemicals, etc. The Comsol Multiphysics computational modeling program was used as an optimization tool. It is based on the finite element method, which allows you to accurately model the problems of the hydrodynamic profile. In this article, the simplest form of a microchannel is considered – a 0.75 mm circular channel with a mixing cell. The mathematical modeling of the process is given, the optimality criterion adequate for the task is determined. As one of the components of this criterion, diodicity was used – a criterion that determines the ability to pass a stream in the forward direction, provided there is a reverse flow. As a result of this work, the most optimal shape of the microreactor channel satisfying the required process conditions was identified, the main hydrodynamic parameters were obtained and the dependence of the diode on the criterion used was determined.