bluuebunny/crossref_metadata_2025 huggingface dataset:
STAN BADAŃ NAD DZIEJAMI PUSZCZY KAMPINOWSKIEJ
Authors: Sukiennik Edgar
Published: September 2018

Kampinos Forest, also known as the Kampinos National Park, is a large forest complex located north-west of Warsaw. This is a unique natural heritage resource full of various forms of wildlife and many types of animals. In this remarkable natural monument are also to be found traces of human activity. Forest areas remained untouched for a long time, but since the 15th century people have begun the first settlements and villages. Within a few hundred years there has been created in this area many towns, parishes and centers of agricultural and forestry. During the Polish uprisings of the 19th and 20th centuries, the forest terrain was favorable to guerilla actions and is now a place of burial for several thousand people who are buried in military cemeteries. These topics were studied by historians, who wanted and still want to show the area of human activity and the evolution of the relationship between nature and man. The Kampinos Forest is seen in many publications as the place for daily life of inhabitants from the Middle Ages to the present day. This article is an attempt to discuss the current trends of historical research in this part of Mazovia. It also shows the perception of events by the authors. The issues of nature, landscape formation, geological processes and environmental protection are not included, because they belong to other fields of science and have a separate research methodology.
Prepozyci prepozytury Kraśnickiej Kanoników Regularnych Laterańskich od fundacji do reformy w 1628 roku
Authors: Łatak Kazimierz
Published: September 2018

This article focuses on the prepositions of the monastery of the Canon Regular of the Lateran in Krasnik from its foundation in May 1468 to the reform of 1620-1627. Founded by Jan Rabsztynski of Teczyn, the owner of Krasnik goods, the monastery was considered as one of the prominent centers in terms of religions, social and cultural activity in the Lublin Region. Therefore, the studying of its history, culture and religious activities are important for getting to know the history of the city and its region. The culture of the monastery influenced the culture of the local environment, while the culture of the surroundings area left traces in the culture and activities of the monastery.
Karol Wojtyła senior w wojsku austriackim i polskim
Authors: Kindziuk Milena
Published: September 2018

Little is known and studied of the Military personal records of Karol Wojtyla, from Vienna Kriegsarchiv until now which in turn has allowed for the accurate reproduction of his curriculum vitae, as well as taking into account the main steps in the course of his military service. Their analysis leads to the conclusion that Karol Wojtyla, senior, John Paul II’s father was a professional soldier for 18 years in service in the Austro-Hungarian Army, in the 56th Infantry Regiment called Regiment of Wadowice, and later became an officer in the Polish Army in the reborn Polish Republic. Throughout the period of his military service he enjoyed a very good reputation: Superiors characterized him as a diligent and honest, valuedfor his ability to communicate in German.
Papiestwo a regnum piastowskie w latach ok. 965-973
Authors: Latoszek Paweł
Published: September 2018

The earliest mention of relations between the Holy See and Mieszko’s I country is the text found on the nonexistent Bolesław Chrobry’s tomb. This text speaks about sending young Bolesław Chrobry’s heir to Rome, which in usually idnetified with Mieszko’s son, possibly held as a German hostage in 973. The connection between the Holy See and Polish missionary bishop Jordan, who was directly answerable to the Pope, is seen as being problematic. Middle-aged sources tell us that Jordan was established as bishop in Mieszko’s I country in 968, but it is thought that he was ordained Bishop in 967. It is connected with the handing to Otto I, a sword that belonged to the Saxon rebel Wichmann the Younger. The author tries to connect the choosing of Jordan with the establishment of the archbishopric of Magdeburg. There is evidence that Jordan’s nomination happened during synod in Ravenna in April 967. During that synod, the organization of Church structures in Slavic countries was carried out. Because only the Pope could issue the license to prosylete the pagans, the author believes that relations were established before the baptism of Mieszko I.
A smart phone application for the mothers of premature infants (Preprint)
Authors: Ayatollahi Haleh , Nourani Aynaz , Mirnia Kayvan
Published: September 2018

BACKGROUND

Considering the large number of premature infants and the importance of providing health care, clinical examinations, and home care for them, mothers should be trained and necessary information should be given to them.

OBJECTIVE

The aim of this research was to develop a mobile application to educate mothers of premature infants.

METHODS

This research was completed in 2017 and carried out in two phases. In the first phase, the information needs of mothers (n=60) were investigated. In the second phase, a prototype of the mobile application was developed based on the results derived from the first phase. Finally, the mobile application was evaluated by using a standard questionnaire.

RESULTS

The mobile application covered four main areas, including "physical conditions and emotional needs", "nutrition, sleep and hygiene", "medical and nursing needs" and "vaccination and growth curve". The results of the usability testing showed that the users were satisfied with the application.

CONCLUSIONS

Mothers of premature infants tend to increase their knowledge about their infant’s requirements. The mobile application designed in the current study can help mothers to be informed about the premature infants' requirements. Further research is required to evaluate the effectiveness of using this mobile application.
Do-It-Yourself Gamified Cognitive Training: Viewpoint (Preprint)
Authors: van de Weijer Sjors CF , Kuijf Mark L , de Vries Nienke M , Bloem Bastiaan R , Duits Annelien A
Published: September 2018

UNSTRUCTURED

Cognitive decline is an important nonmotor symptom in Parkinson disease (PD). Unfortunately, very few treatment options are available. Recent research pointed to small positive effects of nonpharmacological cognitive training in PD. Most of these trainings are performed under supervision and solely computerized versions of (traditional) paper-pencil cognitive training programs, lacking rewarding gamification stimulants that could help to promote adherence. By describing 3 different self-invented ways of cognitive gaming in patients with PD, we aimed to raise awareness for the potential of gamified cognitive training in PD patients. In addition, we hoped to inspire the readers with our case descriptions, highlighting the importance of both personalization and cocreation in the development of games for health. In this viewpoint, we have presented 3 PD patients with different ages, with different disease stages, and from various backgrounds, who all used self-invented cognitive training, including elements of personalization and gamification. To indicate generalization into a larger PD population, the recruitment results from a recent cognitive game trial are added. The presented cases show similarities in terms of awareness of their cognitive decline and the ways this process could potentially be counteracted, by looking for tools to train their cognition. On the basis of the response of the recruitment procedure, there seems to be interest in gamified cognitive training in a larger PD population too. Gamification may add to traditional therapies in terms of personalization and adherence. Positive results have already been found with gamified trainings in other populations, and the cases described here suggest that PD is also an attractive area to develop and test gamified cognitive trainings. However, no results of gamified cognitive trainings in PD have been published to date. This suggests an unmet need in this area and may justify the development of gamified cognitive training and its evaluation, for which our considerations can be used.
Defining Empowerment and Supporting Engagement Using Patient Views From the Citizen Health Information Portal: Qualitative Study (Preprint)
Authors: Risling Tracie , Martinez Juan , Young Jeremy , Thorp-Froslie Nancy
Published: September 2018

BACKGROUND

The increasing presence of technology in health care has created new opportunities for patient engagement and with this, an intensified exploration of patient empowerment within the digital health context. While the use of technology, such as patient portals, has been positively received, a clear linkage between digital health solutions, patient empowerment, and health outcomes remains elusive.

OBJECTIVE

The primary objective of this research was to explore the views of participants enrolled in an electronic health record portal access trial regarding the resultant influence of this technology on their feelings of patient empowerment.

METHODS

The exploration of patient empowerment within a digital health context was done with participants in a tethered patient portal trial using interpretive description. Interpretive description is a qualitative methodology developed to pragmatically address clinical health questions. Patient demographics, self-reported health status, and self-identified technology adaptation contributed to the assessment of empowerment in this qualitative approach.

RESULTS

This research produced a view of patient empowerment within the digital health context summarized in two overarching categories: (1) Being Heard and (2) Moving Forward. In each of these, two subcategories further delineate the aspects of empowerment, as viewed by these participants: Knowing More and Seeing What They See under Being Heard, and Owning Future Steps and Promoting Future Care under Moving Forward. This work also highlighted an ongoing interconnectedness between the concepts of patient empowerment, engagement, and activation and the need to further articulate the unique aspects of each of these.

CONCLUSIONS

The results of this study contribute needed patient voice to the ongoing evolution of the concept of patient empowerment. In order to move toward more concrete and accurate measure of patient empowerment and engagement in digital health, there must be further consideration of what patients themselves identify as essential aspects of these complex concepts. This research has revealed relational and informational elements as two key areas of focus in the ongoing evolution of patient empowerment operationalization and measure.
COMPARISON AND CHARACTERIZATION OF INCLUSION COMPLEXES AND SOLID DISPERSIONS IN ENHANCEMENT OF DISSOLUTION RATE OF POORLY WATER SOLUBLE DRUG
Authors: Earle Radha Rani , Jammu Rambabu , Usha Lakshmi , Lingam Ratna Kanth
Published: September 2018

Objective: The purpose of the present study was to enhance solubility and dissolution characteristics of indomethacin by preparing inclusion complexes with hydroxypropyl β-cyclodextrin (HP β-CD) and solid dispersions with PEG 6000 to enhance its in vitro drug release and to further formulate it as a tabletMethods: Solid dispersions (SDs) and inclusion complexes (ICs) of Indomethacin with PEG 6000 and HP β-CD respectively were prepared to enhance the dissolution rate of this poorly water-soluble drug belonging to BCS class II. A comparison was made between two systems: solid dispersions with PEG 6000 obtained using melting and solvent evaporation technique, inclusion complexes with HP β-CD prepared by kneading technique. SDs were prepared in 1:1, 1:2, 1:3 and ICs in 1:0.25, 1:0.5, 1:1 w/w ratios of drug: polymer. Both the systems were characterized by FTIR, SEM, DSC, X-RD.Results: The dissolution of indomethacin increased with the increase in the concentration of the polymers. F4 and F9 formulations showed complete drug release in less than 30 min. Dissolution studies indicated that cyclodextrin complexes showed a better enhancement of dissolution rate when compared to solid dispersions. CDs were found to be more effective than PEGs at lower concentrations. These formulations were further compressed as tablets.Conclusion: The FTIR and DSC studies showed that no interactions existed between the drug and the polymer.
SUSTAINED RELEASE TABLETS OF SORAFENIB-SILIBININ COMBINATIONS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA
Authors: Mishra Savita , Hora Sandhya , Shukla Vibha , Das Mukul , Kharkwal Harsha , Katare Deepshikha Pande
Published: September 2018

Objective: The aim of this study was to develop polymer coated sustained release tablet using sorafenib and silibinin combination for the treatment of hepatocellular carcinoma.Methods: The qualitative analysis such as weight variation, friability, hardness, interaction studies, disintegration and in vitro release were performed to validate formulated tablets. We have maintained the acceptable official limits for weight variation, friability, hardness and disintegration time according to prescribed pharmacopoeial recommendation. In vitro drug release studies were performed using USP-II (paddle type) dissolution apparatus. The MTT assay was performed for assessment of Cell viability of drug combination for tablet formulation. Molecular docking studies have been performed to determine the combinatorial mode of action for the tablet formulation.Results: Friability and weight variation were less than 1% for each formulation, which were within range of prescribed pharmacopoeial recommendation. The hardness of 20 tablets showed 5-6.5Kg/cm2 for all formulations 5-6.5Kg/cm2. The optimized formulation resulted in 98% drug release after 28 h. The present study reports the synergistic effects of drug combination to inhibit cell growth in HepG2 cell line. Molecular docking studies showed that sorafenib has high binding affinity for B-Raf vascular endothelial growth factor receptor β and protein kinase B. Silibinin showed binding affinity with MAP kinase-11, protein phosphatase 2 A and tankyrase.Conclusion: The present study reports for the first time a novel formulation for sustained release and reduced toxicity of sorafenib with enhanced inhibitory effect of the drug combination on cancerous hepatic cell line as well collaborative mechanism of action for the formulation.
SOLID LIPID NANOPARTICLES: A PROMISING APPROACH FOR COMBINATIONAL DRUG THERAPY IN CANCER
Authors: Lala Rita R. , Shinde Amol S. , Nandvikar Nikita Y.
Published: September 2018

Combination therapy for cancer treatment is accepted worldwide due to the generation of synergistic anticancer effects; restrain in multidrug resistance (MDR) or tumor resistance by different mechanisms of action and minimization of dose-dependent toxicity. Recently developed Solid lipid nanoparticles (SLNs) are matrix composed of lipid which is solid at both room and body temperature and hence it is as an alternative to other nanocarrier systems. SLNs after oral administration get absorbed by lymphatic pathway due to stimulation of chylomicron formation. Thus, it avoids all consequences related to an oral drug delivery system and improves oral bioavailability. SLNs based combination drug delivery to tumor tissues reduces the problems associated with chemotherapy. The targeted and sustained delivery of chemotherapeutic agents reduces the dose by achieving high concentrations at the target site, without altering the normal tissues. In this article, we have reviewed and focused on SLNs as a drug delivery system; ingredients used in formulating SLNs and developed two or more drugs in a single formulation of SLNs as drug delivery. This article also focuses on the fact that SLNs as a combination drug delivery provides an attractive approach in future prevention and beneficial for the treatment of cancer by increasing its therapeutic efficacy.
RESEARCH AND DEVELOPMENT OF DIAZEPAM SOLID DISPERSION POWDER USING NATURAL POLYMERS
Authors: Handa Uditi , Saroha Kamal
Published: September 2018

Objective: The objective of this study was to enhance the solubility and dissolution rate of a poorly water-soluble drug by solid dispersion (SD) technique, in order to conduct an investigation of the effect of these natural hydrophilic polymers on release mechanism from SD.Methods: The SD of diazepam (DZM) were prepared by using modified sodium alginate (SA) and modified guar gum (GG) in different drug: polymer ratios (1:1 and 1:2) by using physical mixture method (PM) and fusion method (FM). Further, the formulations were characterized for calibration curve, Fourier transforms infrared spectroscopy (FTIR) studies, % age practical yield, drug content estimation, solubility studies, dissolution studies.Results: The pure drug and SD were characterized by pre and post-formulations studies. The %age practical yield ranged from 92.9±0.25 to 49±0.57%, and the drug content estimation ranged from 99.34±0.40 to 65.25±0.25 %. The FTIR studies shown that the compatibility between pure drug and natural polymers was stable. All the SD showed improved solubility as compared to the pure drug (PD). SD prepared with modified SA (1:2) by PM and FM shown the huge enhancement of solubility and dissolution rate of the DZM. This can be specific to the improvement in wettability and dispersibility, as well as enhances the drug amorphous fraction.Conclusion: On the basis of the research study, the SD technique shows the enhancement in the solubility of poorly water-soluble drug using natural polymers. SD containing natural polymers prepared with PM and FM shown the remarkable improvement in the release outline compared with PD, DZM.
PREPARATION AND EVALUATION OF ATENOLOL-β-CYCLODEXTRIN ORALLY DISINTEGRATING TABLETS USING CO-PROCESS CROSPOVIDONE-SODIUM STARCH GLYCOLATE
Authors: Parfati Nani , Rani Karina Citra , Charles Nathanael , Geovany Valencia
Published: September 2018

Objective: The aim of this current research was to formulate and analyze the characteristics of atenolol-β-cyclodextrin which using co-process crospovidone-sodium starch glycolate as the disintegrants. Evaluation which has been conducted on orally disintegrating tablets consist of wetting time, water absorption ratio, in vitro dispersion time, and dissolution.Methods: Inclusion complex of atenolol-β-cyclodextrin which were prepared using solvent evaporation method, then formulated using co-processed crospovidone-sodium starch glycolate 1:1 (formula 1) and 1:2 (formula 2) into orally disintegrating tablets by direct compression technique. Orally disintegrating tablets of atenolol-β-cyclodextrin using a physical mixture of crospovidone-sodium starch glycolate 1:1 (formula 3), 1:2 (formula 4) was also prepared as a control. The prepared formulations (F1-F4) were evaluated by several parameters such as wetting time, water absorption ratio, in vitro dispersion time, and dissolution.Results: Orally disintegrating tablets of atenolol-β-cyclodextrin using co-processed crospovidone-sodium starch glycolate 1:1 (formula 1) showed shorter wetting time (53.53±2.26 seconds) and in vitro dispersion time (47.44±2.49 seconds) compare to the other formulas. Formula 1 also exhibited the highest dissolution efficiency compare to the formula which was used in the physical mixture. The results of this study also revealed that there was a high correlation between in vitro dispersion time and dissolution efficiency of atenolol-β-cyclodextrin orally disintegrating tablets.Conclusion: Orally disintegrating tablets of atenolol-β-cyclodextrin showed enhanced dissolution efficiency due to the presence of inclusion complex and co-processed crospovidone-sodium starch glycolate. Formula 1 was found to be the best formula in this study. This formula effectively reduces in vitro dispersion time, hence the dissolution efficiency became higher.
RATIONAL FOR THE USE OF COCONUT OIL-BASED ANTI-MYCOTIC PESSARIES TO COMBAT RECURRENT VAGINAL INFECTION: IN VITRO/IN VIVO EVALUATION AND PRELIMINARY PROSPECTIVE CLINICAL INVESTIGATION
Authors: Kamel Rabab , Abbas Haidy
Published: September 2018

Objective: Coconut oil (CO) was used in combination with metronidazole in order to prepare vaginal pessaries ameliorating the use, delivery and efficacy of the anti-mycotic treatment.Methods: To prepare the metronidazole–loaded pessaries, different lipids, namely: suppocire NA15 (SNA), suppocire NAIS10 (SIS), suppocire AM (SAM) and ovucire WL 2944 (OWL) were used alone or in combination with coconut oil in a ratio of 1:1. Prepared pessaries were subjected to characterization and evaluation of physical properties, drug release, anti-microbial effect, in vivo studies and histopathological examination.Results: In the case of all the lipids, coconut oil improved the physical properties which can allow better use and performance of the pessaries. Among the prepared pessaries, the OWL/CO-based pessary (P8) showed the highest drug release profile (P<0.05). Characterization was done using X-Ray diffraction. Microbiological study showed the superiority of OWL/CO-based pessaries over OWL-based pessaries at different time intervals. Histopathological studies of the vagina of female Wistar rats showed that in the case of the Candida albicans-infected group treated with the selected pessary, the mucosal and muscular layer returned to its normal structure, in addition to the disappearance of the cauliflower-like projections and the newly formed blood capillaries, seen in the Candida albicans-infected group. The questionnaire done in volunteers suffering from recurrent vaginal infection reported a significant decrease (reaching 93 %) in the severity of the symptoms, after the use of the suggested pessaries (P8) (P<0.05). Also, the suggested product had high patient acceptability. The results reported after the use of P8 were better than those of Amrizole® vaginal suppository.Conclusion: The current study can present a successful, effective and easy to use product with low cost and minimal side effects.
DEVELOPMENT, CHARACTERIZATION AND SKIN IRRITATION OF MANGOSTEEN PEEL EXTRACT SOLID DISPERSION CONTAINING CLAY FACIAL MASK
Authors: Pan-on Suchiwa , Rujivipat Soravoot , Ounaroon Anan , Kongkaew Chuenjid , Tiyaboonchai Waree
Published: September 2018

Objective: To develop a clay facial mask containing mangosteen peel extract solid dispersion (MPESD) for enhancing α-mangostin bioavailability and to determine suitable clay-based facial mask.Methods: The MPESD were prepared by a melting-solvent method employing PVP K30 and poloxamer 188 as a carrier. The water solubility was determined by HPLC method. The in vitro skin permeability was examined using porcine ear epidermis. The effects of clay types on the physical stability of MPESD and α-mangostin adsorption capacity were evaluated. The skin irritation was determined by 4 h human patch test.Results: After dissolved optimal formulation of MPESD in water, the spherical micelle was observed with a mean size of ~150 nm and showed significantly α-mangostin water solubility enhancement of ~7 mg/ml, 700 times greater than MPE. Upon mixing the MPESD with clays, a dry powder was obtained. In vitro permeation studies of the MPESD mixed with titanium dioxide showed lowest α-mangostin permeation, while MPESD mixed with mica or talcum showed similar permeation profile as free MPESD solutions. No sign of skin irritation was observed in volunteers after application of the MPESD-based clay facial mask patch on the inner forearm skin for 4 h.Conclusion: MPESD demonstrates a promising technique for improving water solubility and permeation of α-mangostin which reducing the staining effect. In addition, it is safe for topical application and cosmetically acceptable.
APPLICATION OF LIQUISOLID TECHNOLOGY TO ENHANCE THE DISSOLUTION OF CEFIXIME FROM ITS ORAL CAPSULES
Authors: Mahdi Zainab H. , Maraie Nidhal K. , Al-juboori Zahraa Amer
Published: September 2018

Objective: Oral drug delivery is the most desired route for drug administration for its well-known features. Therefore, many attempts were implemented to improve the poor solubility of many active ingredients in order to enhance their dissolution and absorption via the oral route. From these, the liquisolid system is a very promising technology for enhancing solubility and bioavailability of poorly soluble drugs.Methods: In this research, oral capsules of cefixime were prepared by liquisolid technique after mixing different concentrations of the drug with propylene glycol (non-volatile solvent), followed by their addition to different proportions of microcrystalline cellulose and aerosil i.e. different carrier: coating (R-value). The liquisolid capsules were evaluated for In vitro disintegration and dissolution in addition to content uniformity and weight variations. Furthermore, solubility studies, scanning electron microscope (SEM) were performed to the optimum formula. Finally, the release profile of the optimum formula was compared with the marketed cefixime capsules.Results: Liquisolid formula (F3) with 70% cefixime and R-value equals 10 was selected as the optimum formula having higher % release in 45 min (99.5%±0.53) compared to other formulas with faster release rate in the first 20 min than marketed capsules. It had an acceptable disintegration time (25 min±0.76), content uniformity (197.6±0.92) and weight variation (698.04±0.16). Results of solubility study, SEM assured enhancement in solubility and dispersibility of the drug.Conclusion: This research proved that liquisolid system is a promising technology in improving the solubility and dissolution of cefixime from its capsules and hence it may improve its absorption and oral bioavailability.
APPLICATION OF FTIR SPECTRA COMBINED WITH CHEMOMETRICS FOR ANALYSIS OF CANDLENUT OIL ADULTERATION
Authors: Yuliani Fitri , Riyanto Sugeng , Rohman Abdul
Published: September 2018

Objective: The aim of this study was to use FTIR spectroscopy in combination with chemometrics techniques for quantification and classification of candlenut oil (CnO) from oil adulterants, namely sunflower oil (SFO), soybean oil (SyO), and corn oil (CO).Methods: The spectra of all samples were scanned using Fourier Transform Infrared (FTIR) Spectrophotometer using attenuated total reflectance (ATR) as sampling technique at mid infrared region (4000-650 cm-1). Multivariate calibrations of principle component regression (PCR) and partial least square regression (PLSR) were used for quantitative models to predict the levels of CnO in the binary mixtures with SFO, SyO, and CO.Results: The results showed that CnO in SFO was best quantified using PCR at wavenumbers region of 3100-2800 cm-1. Quantitative analysis of CnO in SyO was carried out using PLSR with normal spectra mode using combined wavenumbers of 1765-1625 and 839-663 cm-1, while CnO in CO was analyzed quantitatively using normal spectra at wavenumbers of 970-857 cm-1. The coefficient of determination (R2) obtained were>0.99 with low values of root mean square error of calibration (RMSEC) and root mean square error of prediction (RMSEP). The results of discriminant analysis revealed that authentic CnO can be discriminated from CnO adulterated with SFO, SyO and CO using selected wavenumbers.Conclusion: FTIR spectroscopy combined with chemometrics could be used as rapid and reliable method for authentication of candlenut oil (CnO) adulterated with other oils.
A NOVEL STABILITY-INDICATING REVERSE PHASE LIQUID CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN AND TENELIGLIPTIN IN PURE AND PHARMACEUTICAL FORMULATIONS
Authors: Swetha A. , Kuber B. Ramya
Published: September 2018

Objective: The present method was proposed to develop a simple, sensitive, rapid, accurate and stability-indicating reverse phase-high performance liquid chromatographic (RP-HPLC) method for the simultaneous estimation of metformin and teneligliptin in pure and pharmaceutical formulations. Methods: The chromatographic separation was done on Discovery [250 mm X 4.6 mm: 5 μm is particle size] using a mobile phase composed of 0.1% orthophosphoric acid buffer: acetonitrile [65:35, v/v], the flow rate is 1 ml/min and the detection was carried out with a photodiode array (PDA) at 260 nm.Results: The retention time of metformin and teneligliptin were found to be 2.517 min and 3.687 min, respectively. Stability indicating studies were conducted under the guidelines of an international conference on harmonization [ICH] Q1A R2 and the developed method was validated as per the guidelines of ICH Q2 R1. The linearity was found in the range of concentration of 125-750 μg/ml and 5-30 μg/ml for metformin and teneligliptin. The lower limit of detection (LOD) and lower limit of quantification (LOQ) was found to be 0.02μg/ml and 0.07 μg/ml for metformin and 0.19 μg/ml and 0.56 μg/ml for teneligliptin, respectively.Conclusion: A novel stability-indicating reverse phase liquid chromatographic method developed for the simultaneous estimation of metformin and teneligliptin. The proposed method was adopted for the routine estimation of metformin and teneligliptin in bulk and pharmaceutical dosage forms.
Cartografías espaciales y mentales. Construcción y relación con el paisaje como escenario de la interacción
Authors: López Carmona Juan Alejandro
Published: September 2018

La construcción de cartografías mentales es un proceso esencial, pues garantiza una adecuada interacción con los elementos del mundo. Estas representaciones fungen como simulaciones o mapas de navegación; también cumplen un papel fundamental en la relación y simbolización de las experiencias. Si se tiene en cuenta que los procesos de percepción están definidos por una gran cantidad de elementos que devienen del mundo físico y han de confrontarse con otros que hacen parte de la interpretación, como la memoria, conviene revisar brevemente algunas formas de relación entre mente y entorno, de tal forma que se pueda comprender la simultaneidad en las mismas; esto con el fin de comprender el paso del entendimiento subjetivo a los imaginarios colectivos, así como para apreciar la importancia de la sensorialidad en estos encuentros.
Esta reflexión tiene el propósito de extender las herramientas de racionalización en procesos de planificación de mediaciones objetuales u objetos de diseño, ya que permite al diseñador tener un panorama claro de las consecuencias de las afectaciones sensibles en las cartografías mentales como instrumentos para la interacción entre humanos y mundo, fundamento de las relaciones que se dan en el espacio, que se hacen colectivas en el encuentro con otros individuos y a través de los objetos funcionales, comunicativos y decorativos presentes en el paisaje.
Nuevo modelo de innovación para el contexto organizacional: una relación entre el emprendimiento corporativo y las partes interesadas
Authors: Valencia-DeLara Pilar , Escobar-Sierra Manuela , Calderón-Valencia Felipe
Published: September 2018

El propósito del presente estudio es proponer un nuevo modelo de innovación para el contexto organizacional, ante la falta de consenso en torno al tema y la ausencia de un modelo de innovación generalizable e integrador. Para lograr este objetivo se desarrolla un análisis bibliométrico mediante el software VOSviewer®, que permite identificar conceptos recurrentes a los modelos de innovación, entre los que se resaltan la competitividad, las organizaciones, las culturas y los sistemas. Posteriormente, estos hallazgos pasan a ser contrastados con en el caso de estudio colombiano, que sirve como fundamento para proponer un nuevo modelo de innovación para el contexto organizacional, desde su relación con las partes interesadas y el emprendimiento corporativo, en donde el punto de partida y de llegada son las mismas organizaciones y las partes interesadas quienes desarrollan sus procesos de innovación siguiendo alguno de los modelos referenciados en la literatura. Finalmente, se resalta la importancia de incluir nuevos actores que propicien la interdisciplinariedad de los estudios sobre innovación, la medición de sus resultados, la aplicación del modelo propuesto en contexto empíricos para propiciar su generalización, la definición de políticas e instrumentos públicos conexos que permitan ampliar al alcance del modelo, entre otros.
Enseñanza en ciencias: la investigación como estrategia pedagógica
Authors: Salamanca Meneses Ximena , Hernández Suárez César Augusto
Published: September 2018

Este artículo se contextualiza en el conjunto reciente de investigaciones llevadas a cabo en torno al uso de la Investigación como Estrategia Pedagógica (IEP) para la producción de conocimiento, que se insertan en un plano más general en el modelo de educación por competencias y las teorías constructivistas del aprendizaje. El propósito de la investigación ha sido establecer si las competencias científicas de los estudiantes de grado décimo de educación media se incrementan y mejoran tras la aplicación de la IEP en el área de química. Para ello se trabajó con estudiantes de una institución educativa pública rural de un municipio en Norte de Santander, Colombia. El diseño de la investigación es cuasiexperimental y permitió establecer el nivel de competencias científicas (‘uso comprensivo del conocimiento científico’, ‘explicación de fenómenos’ e ‘indagación’) antes y después de la aplicación de la estrategia. Posteriormente, los resultados de ambas mediciones fueron comparados, de lo cual se concluye que la IEP fortalece las tres competencias científicas señaladas por cuanto existen diferencias estadísticamente significativas antes y después de la aplicación de esta estrategia.
¿Hacia una nueva definición de utilidad del conocimiento científico? Primer análisis de los proyectos de desarrollo tecnológico y social (PDTS) en Argentina
Authors: Alonso Mauro Ricardo
Published: September 2018

¿Qué definición de utilidad del conocimiento científico producido por las humanidades se desprende de la política en ciencia y tecnología para las ciencias sociales y humanidades? ¿Qué mecanismos llevan adelante los investigadores en lo que respecta a instrumentos de investigación orientada?
En el presente trabajo se presentan los primeros resultados del trabajo de campo de relevamiento de los primeros Proyectos de Desarrollo Tecnológico y Social (PDTS) del área de ciencias sociales y humanidades. Los PDTS son proyectos de investigación orientada que introducen elementos novedosos en lo que respecta a la evaluación de los académicos como así también respecto de la vinculación con actores no académicos.
El artículo se ocupará de describir la política pública a la que hacemos referencia haciendo hincapié en los elementos novedosos que en la misma se identifican contextualizando su surgimiento y las tensiones que en ella se expresan en relación a relación ciencia-sociedad-universidad; presentar la estrategia de análisis cualitativo llevada a cabo junto con un análisis de los insumos provenientes de la primera etapa de trabajo de campo y finalmente esbozar las primeras conclusiones que se desprenden del análisis del trabajo de campo y la revisión bibliográfica y documental.
Modelos de propagación-degradación del conocimiento científico y tecnológico
Authors: Escobar Ortiz Jorge M.
Published: September 2018

Este artículo presenta un análisis de los modelos de propagación-degradación del conocimiento científico y tecnológico en la divulgación científica, no desde categorías como la oposición entre déficit y democracia u otras similares, sino desde la categoría de conocimiento en tránsito. El artículo empieza con una discusión de la falta de consenso que existe al ocuparse de temas de divulgación científica, que se refleja incluso a nivel terminológico. Luego, pasa a considerar el tratamiento de la divulgación científica desde la oposición entre modelos de déficit y otros modelos comunicativos. Después, entra directamente en el análisis de los modelos de propagación-degradación del conocimiento, desde la perspectiva del conocimiento en tránsito. El artículo termina con algunas ideas sobre la dirección hacia donde ha girado el tema de la divulgación científica, gracias a la crítica que se ha hecho de los modelos de propagación-degradación del conocimiento científico y tecnológico.
Gestor de contenidos y la apropiación del patrimonio urbano: caso Cibermutua.co
Authors: Torres Moreno Iván Mauricio , Hidalgo Guerrero Adriana
Published: September 2018

El presente artículo de resultados parciales de investigación hace parte del proyecto El cibermuseo: un medio para reconocer el patrimonio urbano difuso de Tunja, que narra el cómo se abordó la elección de un gestor de contenidos que permita, dentro de un sitio web, describir y exhibir los elementos de la colección, coadyuvando a alcanzar los objetivos del proyecto macro y logrando su construcción dentro del tiempo estimado para ello.
Aquí se describe la estrategia que se trazó desde tres perspectivas: la primera consiste en el análisis de la interfaz gráfica de un conjunto de sitios web de museos, al tiempo que se revisa documentos que apuntan a lo mismo; la segunda, consiste en la búsqueda y análisis de documentos que describan experiencias similares; y la última, es la revisión de las sugerencias y recomendaciones hechas por expertos en la materia.
Finalmente se toma una decisión, y para establecer su eficiencia se contrasta con la experiencia del usuario con base en los comentarios plasmados en instrumentos tipo cuestionario.
Perfil del ingeniero de sistemas formado por universidades y el perfil exigido en empresas de base tecnológica en Colombia: una comparación
Authors: Jiménez Toledo Robinson Andrés , Martínez Navarro Álvaro Alexander , Hernández Pantoja Giovanni Albeiro , Jiménez Toledo Javier Alejandro
Published: September 2018

En esta investigación se realiza una caracterización del perfil laboral y profesional de los ingenieros de sistemas en Colombia, y se analizan, de manera comparativa, a la luz de estándares internacionales de la Association for Computing Machinery –ACM. Esto con el fin de conocer aspectos de formación de la carrera profesional, así como las oportunidades laborales exigidas por el sector productivo del contexto colombiano. El proceso metodológico de investigación fue asumido desde el paradigma cuantitativo, con un enfoque empírico analítico y tipo de investigación correlacional descriptivo, con un muestreo no probabilístico intencional por conveniencia, tanto de las universidades como empresas de base tecnológica seleccionadas. Uno de sus principales hallazgos consistió en identificar que en las disciplinas de las Ciencias de la Computación (CS) y Sistemas de Información (IS), el perfil laboral requerido por las empresas tiene más exigencias en relación con el perfil laboral con el que egresan los estudiantes de ingeniería de sistemas de las universidades colombianas.
Innovación social y su importancia en la gestión del conocimiento y la participación ciudadana
Authors: Rincón Carlos Elías , Hermith Diana Patricia , Bautista Molina Wilson
Published: September 2018

La innovación social, como motor para el desarrollo de la sociedad en ciencia y tecnología, se aborda en esta reflexión desde dos perspectivas analíticas: la gestión del conocimiento y la participación ciudadana. Este artículo plantea la necesidad de considerar dichas líneas conceptuales para entender a profundidad la relación intrínseca que existe entre proyectos creativos de innovación social, en donde no solo se solucionan problemas específicos, pero también incitan a la inclusión y acción colectiva, dejando en su ejecución un gran rastro de conocimiento nuevo generado, esencial para contribuir en un impacto real en la sociedad o comunidad objetivo. Se realizó una revisión detallada, buscando indicios de actitudes colaborativas, cuya construcción de valores sea para el bien común en democrática estabilidad en comunidades vulnerables buscando innovar durante el abordaje de problemas sociales complejos. Este artículo también busca profundizar en conceptos de innovación ciudadana, sociedades del conocimiento y su aporte en la ciencia, tecnología y sociedad.
El otro lado de la técnica: diferencias y similitudes entre técnica animal y técnica humana
Authors: Mejía Rendón Joan Sebastián
Published: September 2018

La técnica animal ha ocupado un lugar marginal en las reflexiones de la técnica. En la literatura filosófica de la técnica no existe una definición estricta de la técnica animal, sin embargo, ésta es importante para el entendimiento de los límites de nuestra propia técnica. Este trabajo sostiene que es posible establecer una definición sólida de técnica animal partiendo de dos definiciones de técnica humana (noción protésica de técnica y cultura material) y una dimensión particular de las herramientas humanas (herramientas cognitivas). Este trabajo toma una posición naturalista que permite revisar diversos estudios de caso centrados en la capacidad de los animales de fabricar y usar herramientas.
Los instrumentos de la política en ciencia, tecnología e innovación en la Argentina reciente
Authors: Sarthou Nerina Fernanda
Published: September 2018

La noción de instrumentos de política ha sido empleada en diversos estudios académicos que analizan el ámbito de la ciencia, la tecnología y la innovación; sin embargo, ello no se ha traducido en un avance en la caracterización de la política. Este artículo posee como propósito analizar la política pública en ciencia, tecnología e innovación en la Argentina reciente, a través de distinguir y caracterizar las tendencias presentes en materia de instrumentos. Para ello, se realiza una caracterización de los mismos de acuerdo con sus objetivos, con los organismos que se encargan de su aplicación, sus destinatarios y con el momento en que fueron creados. El estudio se basa en el procesamiento de información proveniente de la plataforma Políticas CTI gestionada por RICYT. Del análisis se desprende que la mayoría de los instrumentos son implementados por un único organismo del complejo de CTI; que el sector académico es el destinatario principal y que en los últimos quince años la política de CTI en Argentina ha atravesado un proceso de expansión y diversificación de sus instrumentos de significativa relevancia
Desarrollo de un sistema web y móvil para la gestión de cultivos agrícolas
Authors: Martínez Villalobos Gustavo , Flórez Méndez David , Bravo Osorio Néstor
Published: September 2018

Este artículo presenta resultados de un proyecto de investigación aplicada en el sector de las TIC, para la gestión de cultivos agrícolas con sistema de riego. El proceso fue realizado con varios productores de cultivos en corregimientos y veredas del municipio de Ibagué, mediante la aplicación de encuestas que evidenciaron la necesidad de diseñar un sistema de información que facilite la gestión e interacción remota del usuario con sus cultivos, la programación y el cumplimiento satisfactorio de cada una de sus actividades, optimizando los recursos correspondientes. Este sistema cuenta con una plataforma web y otra móvil, facilitando el acceso a la información y a la programación remota de actividades sobre el cultivo. Los resultados obtenidos demuestran que las aplicaciones desarrolladas en internet y dispositivos móviles pueden generar un impacto positivo y mejorar la forma de vida de los agricultores, con su apropiación y participación social.
The importance of innovation adoption and generation in linking entrepreneurial orientation with product innovation and farm revenues: the case of vegetable farmers in West Java, Indonesia
Authors: Etriya Etriya , Scholten Victor E. , Wubben Emiel F.M. , Kemp Ron G.M. , Omta S.W.F. (Onno)
Published: September 2018

The growth of modern agrifood markets, especially in Indonesia, has stimulated entrepreneurially oriented farmers to seize business opportunities through innovation. This paper aims to investigate in a dynamic agrifood market if entrepreneurial orientation enhances innovation adoption and generation and if both of these actions enhance product innovation and, eventually, farm revenues of vegetable farmers in West Java, Indonesia. The findings demonstrate that entrepreneurial orientation enhances innovation adoption and generation, which in turn enhance product innovation. Finally, product innovation enhances farm revenues. The findings contribute to a better understanding of the role of innovation in facilitating entrepreneurially oriented farmers to perform better when facing a dynamic market. Entrepreneurial orientation enables farmers to innovate by taking risks to anticipate future demand, through either adoption of available innovations or generation of their own innovations, and both options result in new or improved products and eventually enhanced farm revenues.
Gender and job satisfaction in German horticulture
Authors: Meyerding Stephan G.H. , Lehberger Mira
Published: September 2018

There is little known about the links between gender and job satisfaction in the agricultural sector. Considering the ongoing shortage of agricultural staff in Germany, gaining insight into this issue is valuable, in particular, if one is interested in retaining workers in the business and in identifying gender-specific strategies to recruit new staff. For this reason, a survey among employees (N=218) of German horticultural companies was carried out. The results indicate that, while there are no significant differences for job satisfaction between the two genders in general, the determinants of job satisfaction differ substantially in their importance between the genders.
Hubungan antara status ekonomi keluarga dan risiko karies gigi anak usia 0-3 tahun

Relationship between family economic status and dental caries risk of children aged 0-3-years-old

Authors: Yonathan Heidy Stefanie , Riyanti Eriska , Sasmita Inne Suherna
Published: September 2018

Pendahuluan: Status ekonomi keluarga merupakan salah satu indikator penting dalam menentukan karies gigi anak usia 0-3 tahun. Penelitian ini bertujuan untuk menganalisis hubungan status ekonomi keluarga dengan risiko karies gigi anak usia 0-3 tahun. Metode: Penelitian ini bersifat analisis korelasional, dengan teknik multi-stage random sampling. Sampel berjumlah 109 anak yang berusia 0-3 tahun di 5 posyandu kota Bandung. Status ekonomi keluarga dan risiko karies gigi diukur dengan skala berdasarkan Nielsen Media Research dan American Academy of Pediatric Dentistry’s Caries-Risk Assessment Tool. Korelasi kedua variabel dianalisis menggunakan Wilcoxon Signed Rank Test. Hasil: Anak yang berasal dari status ekonomi keluarga rendah memiliki risiko karies gigi yang tinggi. Perhitungan statistik menggunakan uji korelasi Wilcoxon Signed Rank Test dengan α = 5%, diperoleh nilai koefisien korelasi Zhitung = -8,351 dan signifikansi p-value = 0,000. Simpulan: Terdapat hubungan status ekonomi keluarga dengan risiko karies gigi usia 0-3 tahun. ABSTRACTIntroduction: Family economic status is an important indicator in determining dental caries risk in children ages 0-3 years. The aim of this study is to analize the correlation between family economic status and dental caries risk in children ages 0-3 years. Methods: This correlational analitic study used multistage random sampling technique. Family economic status and dental caries risk were measured in 109 children ages 0-3 years, which had been registered at 5 posyandu in Bandung city, according to Nielsen Media Research scale and American Academy of Pediatric Dentistry’s Caries-risk Assessment Tool. The correlation of variables was analyzed using Wilcoxon Signed Rank Test. Result: The children with low family economic status have high dental caries risk. Statistic calculation using Wilcoxon Signed Rank Test with α = 5%, showed coefficient correlation Z = -8.315, with significancy p-value = 0.000. Conclusion: There is a correlation between family economic status and dental caries risk ages 0-3 years.Keywords: Caries-risk assessment, dental caries risk, family economic status.
Sobre Susan Schroeder, Tlacaelel Remembered: Mastermind of the Aztec Empire
Authors: Peperstraete Sylvie
Published: September 2018

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Sobre Rafael Olea Franco (ed.), Mariano Azuela y la literatura de la Revolución Mexicana
Authors: Torres Sánchez Rafael
Published: September 2018

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Sobre Manuel Miño Grijalva, El obraje. Fábricas primitivas en el mundo hispanoamericano en los albores del capitalismo, 1530-1850
Authors: Salvucci Richard J.
Published: September 2018

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Sobre Florencia Roulet, Huincas en tierra de indios: mediaciones e identidades en los relatos de viajeros tardocoloniales
Authors: Zavala Cepeda José Manuel
Published: September 2018

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