bluuebunny/crossref_metadata_2025 huggingface dataset:
Putting the Pacific fat sleeper Dormitator latifrons (Pisces: Eleotridae) to sleep: effects of clove oil and lidocaine anesthetic
Authors: Aréchiga-Palomera M. A. , Figueroa-Salazar A. G. , Nieves-Rodríguez K. N. , Nolasco-Soria H. , Guerrero-Galván S. R. , Badillo-Zapata D. , Vega-Villasante F.
Published: June 2023

Abstract Among the different handling techniques in aquaculture, the use of anesthetics has had a growing interest focused on guaranteeing animal welfare, and reducing possible stress situations during general handling. The aim of this study was to present the use of eugenol and lidocaine with non-invasive anesthesia procedures in Dormitator latifrons, in which the different stages of anesthesia (induction and recovery) were determined. One hundred and twenty healthy fish of average weight of 73.59 ± 13.53 g and standard length of 17 ± 1.36 cm were used. The experimental fish were subjected to fasting for 24 h prior to the tests. Five fish were subjected to eugenol (25, 50, 100, and 200 µL/L), and lidocaine (100, 200, 300, and 400 mg/L), in triplicate. The time to reach deep and recovery anesthesia were recorded and the data analyzed using ANOVA (α= 0.05). Organisms exposed to anesthetics evidenced early episodes of fast, short-distance swimming (initial hyperactivity) for short periods of time. Survival was 100% with both compounds and concentrations. Fish exposed to a eugenol concentration of 200 µL/L had longer anesthesia times and took longer time to recover (P<0.05). The most effective concentrations for eugenol and lidocaine were of 200 µL/L and 400 µL/L in juvenile fish, promoting rapid inductions, without compromising the conditions for the recovery of the fish. This work provides practical information for handling and transportation D. latiforns with the least possible stress and ensuring animal welfare.
Retomar a vida nos (des)trozos, modos guarani de habitar florestas em Misiones, Argentina
Authors: Mendes Luna
Published: June 2023

Resumo Este artigo parte de uma pesquisa de campo realizada junto aos mbya guarani que vivem nas beiradas da floresta do Parque Nacional Iguazú em Misiones, Argentina. Descrevo como entendimentos e interesses turísticos sobre usos da floresta tentam operar um cercamento e enquadramento dos guarani sobre esse regime, que reagem constituindo um cotidiano de estratégias que tornam a vida nas matas possível. Argumento que o modo guarani de habitar e se relacionar com as florestas toma a multiplicidade como ponto de partida contrastando com concepções ecológicas prístinas de atores da economia turística. Apresento como a retomada realizada nas ruínas de um campo de golfe coaduna entendimentos sobre modos de existir e se relacionar com a paisagem que levam em conta o povo que há em cada local. Explicito como esses contrastes envolvem correlações entre política e natureza que consistem em modos de conceber relações que são também modos de fazer mundos.
Las luchas etnoterritoriales amazónicas y la incorporación de ontologías relacionales en el combate al extractivismo y la crisis ecológica
Authors: Auqui Calle Edison
Published: June 2023

Resumen En este artículo, exponemos la incorporación de ontologías amazónicas en propuestas políticas inherentes a las luchas etnoterritoriales de los pueblos Sarayaku y Zápara. A partir de un análisis etnográfico y análisis crítico del discurso de información disponible en plataformas digitales y documentos oficiales, exponemos cómo la expansión del extractivismo y evolución histórica de las luchas amazónicas han influenciado en que los záparas y kichwas de Sarayaku hayan dado un giro a las luchas ecológicas tradicionales. En defensa de sus territorios, se han incorporado en sus propuestas políticas y discursos, ontologías relacionales que dan cuenta de agentes humanos, no humanos y entidades sintientes que interpelan la esfera política en espacios locales e internacionales. Se concluye que estas cosmopolíticas develan espacios relacionales que escapan a los preceptos ontológicos modernos, pero además, que se exponen conflictos y antagonismos ontológicos marcados por relaciones de poder; en el centro de estas discrepancias existe un desacuerdo crucial, la noción de Naturaleza.
PARTICIPAÇÃO PARENTAL NA DIVULGAÇÃO CIENTÍFICA SOBRE TRANSTORNO DO ESPECTRO AUTISTA (TEA)
Authors: SOARES Mirelly , OLIVEIRA Bianca Hipólito de , BEZZON Rodolfo Zampieri , BIZERRA Alessandra
Published: June 2023

RESUMO A participação de familiares de pessoas com Transtorno do Espectro Autista (TEA), em especial as mães, na busca e na utilização de informações sobre o tema para melhoria da qualidade de vida é reconhecida. Entretanto, pouco se sabe sobre os modos de participação, os conhecimentos, as ferramentas de circulação de informação, as representações envolvidas ou as determinações decorrentes desses processos. Com o objetivo de compreender os modos de participação de familiares de pessoas com TEA em ações comunicacionais sobre o tema bem como os elementos culturais relacionados, utilizou-se, como ferramenta teórico-metodológica, o Circuito da Cultura. Aplicou-se um questionário online destinado a familiares de pessoas com TEA, divulgado via associações. A partir de uma análise quali-quantitativa, percebeu-se que a divulgação científica sobre o TEA pode constituir-se como uma importante ferramenta para a comunicação entre sujeitos e coletivos envolvidos com o tema. A busca e a produção de informações e a formação de redes de apoio entre familiares e especialistas promovem transformações em percepções, atitudes e valores no grupo familiar e, muitas vezes, em contextos extrafamiliares.
DISCURSO NARRATIVO Y LECTURA DE CUENTOS EN EL HOGAR POR PADRES A PREESCOLARES QUE PRESENTAN TRASTORNO DEL LENGUAJE
Authors: GRANADA-AZCÁRRAGA Maribel , POMÉS-CORREA María , CÁCERES-ZÚÑIGA Francisca
Published: June 2023

RESUMEN El objetivo del estudio es analizar el discurso narrativo productivo de estudiantes de kínder en escuelas de lenguaje de Chile, considerando Trastorno Específico del Lenguaje (TEL) expresivo y mixto junto a la periodicidad de la lectura de cuentos en el hogar. Ambientes naturales enriquecidos en la familia aportan mayores oportunidades de desarrollo favoreciendo la literacidad, las habilidades lingüísticas y sociales. Los niños y niñas con TEL pueden mostrar dificultades en la narración, afectando el desempeño académico, social y en su calidad de vida. El discurso narrativo en una muestra de 150 preescolares es evaluado, utilizando un instrumento formal a través del recontado de 3 cuentos originales. Se examina la etapa del desarrollo narrativo y la lectura de cuentos realizada por padres en el hogar. Se aplica una ficha para recoger información demográfica de las familias. A través de un estudio descriptivo comparativo, se aplica estadística descriptiva e inferencial (ANOVA de dos factores) para analizar las variables. Los resultados muestran que ni el tipo de TEL, ni la frecuencia de lectura o la interacción de ambas, provocan cambios estadísticamente significativos en el discurso narrativo. Sin embargo, se observan hallazgos cualitativos en la cantidad de narración, en función de la lectura de cuentos.
A ALTERNÂNCIA DE VERBOS COM ARGUMENTO MOTIVADOR NO PB: UM TIPO DE FATORAÇÃO DE ARGUMENTO
Authors: MEIRELLES Letícia Lucinda
Published: June 2023

RESUMO Neste artigo, analisamos um tipo de alternância que nos permite expressar um constituinte complexo, que originalmente ocupa a posição de objeto, em duas posições sintáticas distintas, como ocorre no par de sentenças: os alunos admiram o brilhantismo do professor/os alunos admiram o professor pelo (seu) brilhantismo. Para a análise desse fenômeno, utilizamos a proposta de papéis temáticos enquanto propriedades semânticas discretas de Cançado (2005) e Cançado and Amaral (2016). Propomos que a alternância analisada decorre da fatoração do argumento verbal complexo, sendo determinada por restrições semânticas de nível nominal e verbal. No primeiro nível, os argumentos complexos passíveis de serem fatorados devem denotar uma relação de posse, como no sintagma o brilhantismo do professor, ou uma relação entre um nome eventivo e seu agente, como no sintagma nominal a excelente atuação do artista em o público aplaudiu a excelente atuação do artista/o público aplaudiu o artista pela (sua) excelente atuação. No nível verbal, os verbos que realizam essa alternância podem ser agrupados em uma classe coarse-grained (LEVIN, 2010), pois todos atribuem as propriedades semânticas estativo, objeto de referência e objeto motivador para o seu argumento complexo passível de ser fatorado. Por fim, propomos que a alternância em questão é motivada por fatores pragmáticos relacionados à estrutura informacional dos enunciados analisados.
Mechanical damage of geotextiles induced by recycled construction and demolition waste
Authors: Carneiro José Ricardo , Almeida Filipe , Lopes Maria de Lurdes
Published: June 2023

Construction and demolition waste is one of the most impactful waste streams worldwide, making finding applications allowing its recovery a priority. The use of recycled aggregates from construction and demolition waste as filling materials in geotechnical works, where they may come into contact with geosynthetics, is one of those applications. This work evaluates the mechanical damage induced to five geotextiles with different structures (non-woven and woven) by three recycled aggregates from construction and demolition waste. The damage suffered by the geotextiles was evaluated qualitatively by visual inspection and quantitatively by monitoring changes in their tensile and static puncture behaviour. The results showed that in some cases, the recycled aggregates from construction and demolition waste induced damage to the geotextiles, affecting their properties. The impact of the aggregates depended on (a) their particle characteristics and (b) the physical properties of the geotextiles. For both non-woven and woven geotextiles, the increase in mass per unit area and thickness resulted in better resistance to degradation. The damage caused by the recycled aggregates to 251 and 495 g/m2 non-woven geotextiles was small to negligible. Corundum (standard aggregate) had a more harmful impact on the geotextiles than the recycled aggregates.
Numerical modelling of a tunnel adjacent to a surface structure in liquefiable ground
Authors: Zhang Jinghua , Bilotta Emilio , Madabhushi Gopal S. P. , Yuan Yong
Published: June 2023

Earthquake-induced liquefaction is likely to cause uplift displacements of underground structures and excessive settlements of surface structures. While these two phenomena have been investigated separately in the literature, the case of a shallow tunnel buried adjacent to a surface structure in liquefiable ground has not yet been thoroughly studied. In this paper, the OpenSees platform is employed to numerically model two centrifuge tests on the structure–soil–structure interaction in saturated Hostun sand. The PM4Sand constitutive model is calibrated to capture the non-linear behaviour of the liquefiable ground. Overall, the numerical simulations are in good agreement with the centrifuge test data. The excess pore pressure build-up, the acceleration response of the Hostun sand ground, the uplift of the tunnel and the settlement of the surface structure are simulated with adequate accuracy. Then, the validated numerical models are used to investigate further the structure–soil–structure interaction in liquefiable ground, with a special emphasis placed on the variation of the relative density of the sand, and a parametric analysis is conducted on the responses of the tunnel and the surface structure.
Tanrı İsraf Eder mi?
Authors: Karaağaç Osman
Published: June 2023

Tanrı, her türlü noksanlıklardan uzak, mükemmel bir varlık olarak tanımlanmaktadır. Dolayısıyla Tanrı, her türlü iyiliğin, güzelliğin ve düzenin kaynağı olarak gösterilmektedir. Bu nedenle Tanrı’nın yapmış olduğu her bir eyleminde bir amaç söz konusudur. Bu amaçların bir kısmı insan tarafından bilinirken bir kısmı ise bilinemezliğini korumaya devam etmektedir. Var olan şeylerin bir kısmı doğrudan insan hayatı ile ilgili iken bir kısmı ise dolaylı olarak ilgilidir. Modern dönemde iyi kavramı ile insanın menfaati arasında sıkı bir ilişki gözlemlenmektedir. Bir şeyin iyi olabilmesi için doğrudan insan hayatına fayda temin ediyor olması gerekir. Aksi takdirde gereksiz ve faydasız olarak değerlendirilmektedir. Son zamanlarda bir taraftan evrenin büyüklüğü ve büyük bir kısmının kullanılamayacak olması, diğer taraftan bir takım canlı türlerinin varlık nedenlerinin anlaşılamaması ve insan nesline faydasızlığı ya da zararı üzerinden Tanrı’nın bunları yaratarak israf ettiği şeklinde değerlendirmeler yapılmaktadır. Bu çalışmanın amacı özellikle ateistik düşünceye sahip olan Richard Dawkins ve Victor Stenger’in –eğer varsa- Tanrı’nın birçok gereksiz şey yaratarak israf ettiği şeklindeki düşüncelerinin gerçeği yansıtmadığını göstermektir.
A conceptual technique to mathematically quantify the trajectory of flyrock
Authors: van der Walt J. , Spiteri W.
Published: June 2023

Flyrock remains a significant threat to the health and safety of mine employees and integrity of infrastructure, as well as to the safety of the neighbouring communities and their property. This investigation was motivated by the general lack of fundamental research and mathematically quantifiable data in the literature regarding the relationship between blast design parameters and their impact on flyrock. The focus was to develop a concept that can be used to mathematically quantify the trajectory of flyrock resulting from a blast, which can be used for future research. The ultimate goal for this technique, once it has been fully developed, is to: > Enable mining operations to generate a database with accurate historical flyrock measurements resulting from their blasting operations > Allow research teams to conduct scientific investigations into flyrock and the impact of various blast design parameters > Generate point-cloud data to visualize blasts and flyrock in a virtual reality environment for training and education purposes. This paper summarizes a conceptual technique and preliminary fieldwork that was carried out to determine the technique's feasibility and motivate further development. The results show conclusively that a modified photogrammetric technique is capable of capturing flyrock data for further processing and analysis. The data acquisition procedure can, at this point, be used to meet the first aim of the project, namely to gather a field database of historical flyrock generation. Further development of the technique is ongoing and it is envisioned that the scientific-based technique will provide a method whereby future flyrock studies will be comparable and that assumptions will be limited.
Vegetações de Telhados Verdes Utilizadas em Diferentes Regiões Climáticas para Mitigar o Escoamento Superficial
Authors: Souza Maiza Gleyce Fernandes de , Barros Camille Zamorano Escanoni de , Soares Willames de Albuquerque
Published: June 2023

Os alagamentos são os maiores danos causados pela urbanização intensiva, responsável pela alta impermeabilização do solo. Sob esta perspectiva, os telhados verdes são opções viáveis e sustentáveis para evitar a sobrecarga do sistema de drenagem. A vegetação, portanto, deve ser cuidadosamente selecionada para alcançar a melhor eficiência hidrológica, pois é ela o fator mais influente do escoamento. Este trabalho tem como objetivo, por meio de uma Revisão Sistemática de Literatura (RSL) e com o auxílio do Periódicos CAPES e da ferramenta computacional State of the Art through Systematic Review (StArt), analisar artigos publicados dentro da temática de Telhados verdes (TV) utilizados como alternativa para mitigar alagamentos, identificando as espécies que foram utilizadas em cada estudo, correlacionando com o clima local e identificando os gêneros de vegetais mais utilizadas em diferentes países. Observou-se que a vegetação (VG) mais proeminente associada à frequência no TV foi a Sedum sp, encontrada em mais de 50% dos estudos. Não foi possível identificar consistência ou frequência de seleção de VG em climas tropicais e áridos. Constatou-se também que em regiões de clima continental, todos os estudos utilizaram a Sedum para implementar e desenvolver práticas sustentáveis ​​de controle de escoamento em áreas urbanas. Portanto, é necessário entender o desempenho hidrológico da cobertura vegetal sob diferentes condições climáticas. Com relação a locais com climas tropicais e áridos, mais pesquisas são necessárias para determinar os gêneros  de VG mais utilizados na região.

PALAVRAS-CHAVE: Escoamento Superficial. Alagamento. Drenagem.
Erythrocytic Nuclear Abnormalities and Leucocyte Profiles of Asian Seabass (Lates calcarifer) Exposed to Polluted Seawater
Authors: Senarat Sinlapachai , Sopon Anek , Kettratad Jes , Angsujinda Kitipong , Charoenphon Natthawut , Kosiyachinda Pahol , Kongthong Kitiya , Poolprasert Pisit , Boonyoung Piyakorn , Kongtueng Piyamat
Published: June 2023

Close to industrial activity and a major seaport in the Gulf of Thailand, Sichang Island has frequently suffered from pollution and oil spills. However, the environmental health status of the surrounding waters is relatively unknown. Between December 2017 and January 2018, we reared ninety Asian seabass (Lates calcarifer) in cage nets off the island and sampled blood to investigate nuclear abnormalities in erythrocytes and build leucocyte profiles. The fish were purchased locally and reared in locations where oil spills have been recorded. Environmental parameters were within the range of standard values. Erythrocyte nuclei had segmented, reniform and notched abnormalities; however, they dramatically varied after exposure. At the end of the three-month field experiment, very few micronuclei had been observed. Observed leucocytes were neutrophils, lymphocytes, and monocytes. The percentage of lymphocytes increased considerably, reaching a post-exposure peak at three months. Our data suggest that erythrocytic nuclear abnormalities of Asian seabass could be used as an early warning of toxic pollutants in the marine environment, and as a baseline environmental health indicator for Sichang Island and the surrounding area.
Functional Characterization of a Novel Synthetic Herbicide Resistance Gene in a Model Plant
Authors: Sarwat Sarwat , Shoukat Shehla , Muhammad Amir Zia Muhammad Amir Zia , Shaukat Shaukat
Published: June 2023

As crop losses can occur owing to the abrupt growth of uncontrollable weeds in the field, research is currently being conducted in Pakistan to eradicate herbs. To carry out our proposed research domain, we have designed a novel synthetically modified EPSPS gene that has a potent role in herbicide-resistance development. The novel codon-optimized synthesized mEPSPS sequence was inserted into the pXCSG-mYFP plant expression vector. Results of colony PCR (1400 bp) confirmed the integration of genes into bacteria. For functional validation of pXCSG-mYFP-EPSPS, transient expression in tobacco (Nicotiana benthamiana) in comparison with PBSF-16 was done. Benth infiltration results showed that transient expression was successfully confirmed through ELISA and western blot analysis via anti-YFP antibody in tobacco leaves. For further validation of transient expression, the stable transformation results of the pXCSG-mYFP-EPSPS vector showed that successful transformation was done via two days of co-cultivation followed by selection and regeneration of transformed tobacco plants. The regenerated tobacco plants were then confirmed through gene-specific-based PCR. After PCR-based confirmation, western blot further validates the 26 kDa anti-YFP antibodies expression in transformed tobacco plants. Another important finding of the study was the bar and PAT gene real-time expression elucidating that the bar gene was 4.9-fold more expressive under the 35S promoter than the PAT gene under the nos promoter.
Gibberellic Acid Supplements Mitigate the Sodium Chloride Effects on Onion Seed Germination and Its Physio-Chemical Attributes
Authors: Ikram-Ul Haq Ikram-Ul Haq , Gill Nazia Parveen , Yasin Ghulam , Memon Sahifa , Soomro Zainab , Ahmed Bhatti Faheem , Baloch Mehwish , Baloch Chanda Bakhtawar
Published: June 2023

The mitigative effect of gibberellic acid (GA3) for salt (NaCl) stresses on seed germination attributes of onion (Allium cepa L.) cultivar Nasarpuri was assessed. Seeds were moisturized with NaCl (0-, 100- and 200-mM) and GA3 (250 ppm) before and after sowing for seed germination in 1st week than in 2nd week, GA3 sprayed once foliarly and NaCl in rooting region. At the end of 1st week, an increase in seed germination rate was observed in seeds supplemented with GA3 from control (85.0%) to 97.5% and from NaCl stressed seeds (72.5% and 50.0%) to 85.0% and 62.5%, respectively (p ≤ 0.05). This reduction in seed germination was caused by salt stresses after 96th hours of sowing, inhibition in GA3-biosynthesis GA3 and delay in α-amylases activation observed in salt stressed seed cultures. The seedling vigor index (SVI) was observed higher in foliarly GA3 sprayed cultures of both control as well as saline stressed cultures. The seedlings supplemented with GA3, decrease in malondialdehyde (MDA), H2O2, Na+/K+, Na+ and Cl- contents, while increases seedling biomass, chlorophyll contents, total proteins, and sugars in NaCl stressed seedlings. Interestingly, GA3 also increased (p ≤ 0.05) the osmoprotectants in seedlings including abscisic acid (AsA), carotenoids, phenolics and proline contents to depict in stress alleviation. This study may be concluded by the fact that GA3 minimizes salinity stresses on seed germination as well as further seedling growth with the increased production of organic osmoprotectants as saline stress neutralizers.
Sensitive and Selective Detection of Chloroform by Current-Voltage Using ZnO Nanorods Modified Electrode
Authors: Abdul Hamid Haslinda , Kunakornwattana Panapan , Isa Norain , Abdul Razak Khairunisak
Published: June 2023

The development of in situ chloroform detection is crucial due to the high risk of carcinogenic effects associated with chloroform exposure. In this study, an electrochemical-based chloroform sensor was fabricated using undoped ZnO nanorods on indium tin oxide (ZnONRs/ITO) electrode to detect chloroform in aqueous-phase samples. Based on the results, the FESEM imaging showed that the ZnONRs exhibited an evenly distributed circular structure with a diameter of 62-90 nm, while the EDX and XRD findings confirmed the presence of Zn and O elements deposited on the electrode surface. Furthermore, the phosphate buffer solution (PBS) solution significantly affected the performance of the modified electrode with an optimal concentration and pH of 0.1 M and pH 7. The results also highlighted the vital function of the modified ZnONRs/ITO electrode as an efficient electron mediator and its catalytic potential to induce chloroform oxidation. Most importantly, the modified ZnONRs/ITO electrode was able to detect the presence of chloroform in real seawater samples, where the repeatability and reproducibility tests achieved a Relative Standard Deviation (RSD) of 1.41% and 2.61%, respectively, indicating the exceptional performance of the modified electrode. Moreover, the modified ZnONRs/ITO electrode recorded a low limit of detection and high sensitivity of 1.50 µM and 2.11 µA/cm2·mM, respectively, within a 0.010-10 mM linear dynamic range. In conclusion, the current-voltage (I-V) method proved the reliable, satisfactory, and effective fabrication of the modified ZnONRs/ITO electrode for chloroform sensing in aqueous-phase samples, including in real seawater samples.
Emerging Role of SMYD Family of Proteins in Human Tumorigenesis
Authors: Afshan Bibi Afshan Bibi , Sarfraz Ayesha , Sajjad Amna , Sarfraz Iqra , Munawwar Aasma , Zarbab Aneeqa , Sattar Mehran , Rasul Azhar
Published: June 2023

Protein lysine methylation is a post-translational modification (PTM) that promotes protein complex formation to regulate DNA replication, gene expression, and repair mechanisms. The Su(Var)3–9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing proteins SMYD are lysine methyltransferases that catalyze the methylation of various histone and non-histone proteins. There are five members of this SMYD family, and all of these have conserved SET and MYND domains. The SET domain is divided into two segments by the MYND domain (the S-sequence and a core SET domain). SMYD Family performs a key role in numerous biological functions, including growth, development, apoptosis, and proliferation. SMYD family members are associated with skeletal and cardiac muscle physiology and pathology. Several studies have shown that aberrant lysine methylation plays a significant role in oncogenesis. Recently, the SMYD family has gained importance for its role in various mechanisms involved in cancer development and progressions, such as methylation and modification of tumor suppressor proteins (p53 and pRb), transcriptional factors (STAT3, NF-κB), nuclear proteins (PARP1), chaperons (Hsp90), protein kinases (MAPK, ERK), and cell cycle regulatory proteins (CDKN2). SMYD family proteins drive oncogenesis, lead the way to metastasis, and develop chemoresistance, allowing cancer cells to grow, invade the neighboring tissues, and resist therapeutics. In this review, we summarize SMYD family members' role in different cancers by focusing on their histone and non-histone methylation targets and illustrating the mechanism of SMYD family-mediated oncogenesis.
Combined treatment of high and very high risk prostate cancer: results of neoadjuvant treatment
Authors: Troyanov A. V. , Biryukov V. A. , Zaborsky I. V. , Chaykov V. S. , Dementev I. O. , Shchukina E. O. , Karyakin O. B.
Published: June 2023

Purpose of the study. Assessment of safety and short‑term effectiveness of high and very high‑risk prostate cancer neoadjuvant chemo‑ hormonal treatment without distant metastases.

Patients and methods. Combined hormone chemo‑ radiation treatment of 33 patients with prostate cancer of high and very high risk of progression without distant metastases was performed. Metastases to regional lymph nodes were found in 9 patients according to the examination data (MRI, MSCT), no metastases were detected in 24 patients. All patients underwent combined chemohormonal therapy in the amount of 4 courses of docetaxel intravenously at a dose of 75 mg/m2 every 3 weeks as the first stage of treatment. in combination with androgen deprivation therapy with agonists or antagonists of GnRH before performing radical radiation therapy (combined or remote). All patients underwent neoadjuvant hormone therapy: 16 patients – with the use of GnRH antagonists (Degarelix), 17 – with the use of GnRH agonists (Gozerelin/Leuprorelin/Triptorelin). The toxicity of the presented treatment regimen and its immediate effectiveness – the effect on the level of prostate‑s pecific antigen (PSA), prostate volume, and the quality of urination – were evaluated.

Results. Treatment regimen was highly effective concerning PSA decrease (from initial median level 79,67 ng/ml to 1,45 ng/ml after neoadjuvant treatment), all subjects responded well, no non‑responders observed. Median prostate volume decreased from 44 cm3 to 25 cm3 after treatment, which guaranteed availability and safety of further radical radiation treatment. Urinary function was restored in all subject with initial urinary retention.

Conclusion. Neoadjuvant chemo‑h ormonal treatment was highly effective in PSA level, prostate volume decrease and functional results improvement which secured further radical radiation treatment in one of its types. Toxicity was acceptable, adverse events did not exceed grade II in most cases and did not lead to treatment discontinuation in any cases, while quality of life remained high enough.
Evolution of drug therapy in patients with resectable gastric and esophageal‑gastric junction cancer
Authors: Sedova M. V. , Batov M. A. , Tretyak V. S. , Kolomeytseva A. A. , Khomyakov V. M. , Volchenko N. N. , Fedenko A. A. , Kaprin A. D.
Published: June 2023

Gastric cancer (GC) is the fifth most common malignant neoplasm in the world among all malignant tumors. Currently, the “gold” standard of treatment for patients with non‑metastatic cancer of the stomach and esophageal–gastric junction is surgical treatment, which is complemented by perioperative chemotherapy according to the FLOT scheme, which includes four courses of therapy before surgery and four after. However, according to statistics, less than half of patients complete all adjuvant courses of FLOT chemotherapy due to the high toxicity of the regimen and a decrease in the functional status of patients in the postoperative period. In this regard, studies are being conducted to study the tolerability of total neoadjuvant chemotherapy, when all courses are held at the preoperative stage in order to carry out all stages of treatment in full. International studies have shown the results of the use of targeted (ramucirumab, trastuzumab, pertuzumab), immune drugs (pembrolizumab, nivolumab, ipilimumab), S‑1 in combination with chemotherapy as part of the combined treatment of gastric and esophageal‑ gastric junction cancer. The emergence of new therapeutic agents previously studied in metastatic GC may change approaches to the treatment of localized and locally advanced GC.

The review presents the features of perioperative therapy regimens in patients with resectable gastric and esophageal‑ gastric junction cancer in order to reduce the frequency of local and long‑term relapses and improve further prognosis.
Reproduction and restoration of Mesoamerican codices: problems and challenges
Authors:   Taras Shevchenko national University of Kyiv, Stadnik Marie
Published: June 2023

The paper meticulously analyses the developmental trajectory of the reproduction and restoration of Mesoamerican codices within the context of historical and cultural studies pertaining to the region. The significance of qualitatively documenting such sources is underscored. Various technologies employed in the creation of reproductions are tackled, and their respective advantages and disadvantages delineated. The author sheds light on the interplay between technological advancements and the progress made in historical, archaeological, and art historical studies. Specifically, it addresses the improvements in existing documentation methods and the emergence of modern techniques, coupled with the easy access to the information through the Internet. The research primarily relies on freely accessible image sources. The study examines several facsimile editions of the codices that have been published since the 19th century, paying particular attention to the reproductions of the Borgia codex. Through comparative analysis the author evaluated the quality and accuracy of these reproductions, both among themselves and in relation to the original. Additionally, the article presents the author's findings on the digital restoration of two pages of the Borgia codex, undertaken between 2021 and 2023. The manuscript reconstruction process is elucidated, accounting for factors such as image complexity and fragment preservation. Within this framework, the article unveils certain aspects of Mexican mythology and iconography, and explores different perspectives on the interpretation of several scenes depicted in the codex. The results of this study are compared with other extant restorations and reproductions, thereby substantiating their relevance and accuracy. The paper concludes by examining the present state and future prospects of using graphic editors for the restoration of artworks more generally.
KÜLTÜREL ZEKÂ VE İLİŞKİSEL BENLİK DÜZEYİ İLİŞKİSİ: TURİST REHBERİ ADAYLARINA YÖNELİK BİR ARAŞTIRMA
Authors: Göker Gönül , Öztürk Yakup
Published: June 2023

Turist rehberleri kendi ülkelerinin birer kültür elçisi olarak farklı kültüre sahip insanlar ile de güçlü iletişime sahip bireylerdir. Kültürel zekâ ve ilişkisel benlik kavramları ise bireylerin ikili ve sosyal ilişkilerdeki tutum ve davranışlarını ortaya koyan kavramlardır. Turist rehberi adaylarının kültürel zekâ düzeyi ve ilişkisel benlik düzeyleri arasındaki ilişkinin belirlenmesinin amaçlandığı bu araştırmada ayrıca turist rehberi adayların demografik durumları ile kültürel zekâ ve ilişkisel benlik düzeyleri arasındaki ilişki de incelenmiştir. Literatür araştırmalarından yola çıkıldığında, iki kuram arasındaki ilişkiye yönelik araştırmalara rastlanılmaması, çalışmanın özgünlüğü açısından önem arz etmektedir. Veri toplama aracı olarak anketin tercih edildiği bu araştırmanın evrenini Çankırı Karatekin Üniversitesi, Ilgaz Turizm ve Otelcilik Yüksekokulu’nda eğitim gören 210 Turizm Rehberliği bölümü öğrencisi oluşturmaktadır. Toplanan veriler SPSS ve AMOS programları aracılığıyla analiz edilmiştir. Faktör analizi, T-ti testi ve korelasyon analizleri yapılmıştır. Analiz sonuçlarında adayların kültürel zekâ düzeyleri ile ilişkisel benlik düzeyleri arasında anlamlı bir ilişki olduğu sonucuna varılmıştır. Son olarak adayların demografik durumları ile kültürel zekâ ve ilişkisel benlik düzeyleri arasında anlamlı bir farklılığa rastlanmamıştır. Bu çalışma turist rehberi adayları ve aktif turist rehberleri arasındaki kültürel zekâ ve ilişkisel benlik düzeyi karşılaştırması çalışmalarına öncülük ederek literatüre katkı sağlayabilir. Ayrıca turist rehberlerinin kültürel zekâ ve ilişkisel benlik düzeyleri ile akademik ve mesleki başarılarına yönelik çalışmalar da yapılabilir.
Study of Victims of Alleged Sexual Assault
Authors: Hugar Basappa S. , Hosahally Jayanth S. , Girish Chandra Y. P. , Praveen Shivarama
Published: June 2023

BACKGROUND: Sexual assault has been a major concern to our society. It is one of the most underreported offences to the law enforcement agencies. Such offences are multi-faceted and certain details of the offence may be hard to be unearthed even after a thorough investigation.
AIMS: To study factors associated with reporting of sexual assault cases and to correlate findings with the alleged history.
MATERIALS AND METHODS: The study was conducted in the Department of Forensic Medicine, M.S. Ramaiah Medical College Bangalore from January 2018 and December 2020. All victims of alleged sexual assault brought for medical examination to the Department of Forensic Medicine were interviewed through a detailed questionnaire after taking consent. Relevant information was sought from the victim and the consent from victims. Descriptive statistics for qualitative type of data were summarized using frequency and percentage.
RESULTS: 82 victims those who had come to or brought by the parents or guardian or police with alleged history of sexual assault were subjected for medical examination. All of them were females except two juveniles. Majority of the victims (n=71, 86.5%) were less than 18 years of age and were considered as juvenile / minors under Indian law. Either the victims or their parents reported to the police in most of the cases (n=76, 92.7%). In 53.65% of the cases the alleged assaults were reported to the police after three days of alleged recent sexual assault. The purpose of reporting to the police was because of honour or pride of the parents / guardian in 59.75% of the cases. It was observed that only in four cases there were positive findings of recent penetrative sexual assault in the form of fresh hymeneal tears or presence of spermatozoa in the swabs taken during genital examination.
CONCLUSION: Majority of the victims of alleged sexual assault were minors. Only 12% of them reported to the law enforcement directly without anybody persuading. More than 50% of victims presented to the hospital after 3 days of the alleged sexual assault. In most of minor victims the sexual intercourse was consented, but it was invalid since the girl below 18 years cannot consent for sexual intercourse. Majority of adult victims had consented for sexual intercourse on promise of marriage. In view of these, no physical injuries were seen on victims and positive evidence of sexual assault was detected only in 5% of cases.
EXPORT DIVERSIFICATION AND PRODUCTIVITY GROWTH: FIRM-BASED SECTORAL ANALYSIS IN THE REPUBLIC OF CROATIA
Authors:   Sveučilište u Zagrebu, Ekonomski fakultet Zagreb, Bašić Maja , Novak Ivan , Bošnjak Mile
Published: June 2023

Ovaj rad ispituje utjecaj diverzifikacije izvoza na rast ukupne produktivnosti faktora proizvodnje tristo najvećih izvoznika u Republici Hrvatskoj grupiranih u 13 industrijskih sektora. U radu se koriste godišnji financijski podaci poduzeća za razdoblje od 2006. do 2015. godine agregirani na sektorsku razinu. Empirijska analiza se koristi panel kointegracijom (PMG/ARDL) kako bi ispitala učinak diverzifikacije izvoza u kratkom i dugom roku na ukupnu produktivnost faktora proizvodnje. Diverzifikacija izvoza mjeri se sektorskom klasifikacijom koncentracije vrijednosti izvoza za što se koristi Herfindahl-Hirschmanov indeks. Rezultati pokazuju dugoročnu kointegraciju koncentracije izvoza i ukupne produktivnosti faktora proizvodnje pri čemu veća koncentracija izvoza vodi većoj produktivnosti faktora proizvodnje. Ograničenja ovog istraživanja uključuju vremenski okvir analize zbog nemogućnosti pristupa podacima nakon 2015. godine, te mjeru diverzifikacije izvoza koja se može promatrati u odnosu na izvoz pojedinog industrijskog sektora, proizvoda ili na određena geografska područja, pri čemu su posljednje dvije mjere izostavljene iz analize zbog nemogućnosti pristupa podacima.
IDENTIFYING THE IMPORTANCE OF APPLYING FUNDAMENTAL CRITERIA IN THE ELECTION OF WOMEN TO MANAGEMENT POSITIONS OF COMPANIES IN THE REPUBLIC OF CROATIA
Authors:   Sveučilište u Splitu, Ekonomski fakultet, Mateljak Željko
Published: June 2023

Svako poduzeće tijekom svojeg poslovnog vijeka treba težiti izboru najstručnijih osoba na upravljačke pozicije s ciljem ostvarivanja boljega konkurentnog položaja na domaćim i međunarodnim tržištima. Prilikom izbora na upravljačke pozicije potrebno je primijeniti određene kriterije te poštovati temeljnu zakonsku proceduru preko upravnih organa kao što su skupština društva, upravni odbor i nadzorni odbor. U ovom radu naglasak je na identificiranju važnosti primjene kriterija prilikom izbora žena na upravljačke pozicije. Predmet je ovog rada prepoznati važnost primjene kriterija prilikom imenovanja žena na upravljačke pozicije poduzeća. Problem je u kojem stupnju važnosti poduzeća primjenjuju kriterije prilikom izbora žena na upravljačke pozicije u Republici Hrvatskoj. Istraživanje je provedeno nad 1900 poduzeća u Republici Hrvatskoj. Rezultati istraživanja pokazali su da se identificirani kriteriji primjenjuju prilikom izbora žena na upravljačke procese u Republici Hrvatskoj, ali u različitim stupnjevima važnosti.
Neurotrophic Keratitis: Exploring the Therapeutic Landscape
Authors: Balakrishnan Uma L ,   Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA, Arsenault Samantha M ,   Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA, Khandelwal Sumitra ,   Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA
Published: June 2023

Neurotrophic keratitis is a complex condition with a variety of aetiologies involving damage to the sensory nerves that innervate the cornea, resulting in potentially devastating ocular surface disease. Aetiologies include diabetes, prior herpesvirus keratitis, stroke or compressive damage to the trigeminal nerve, chronic ocular surface disease or contact lens overuse, among others. Management is multidisciplinary; of course, the underlying condition must be addressed and treated. The ocular surface must be stabilized, and depending on the severity, treatment options include artificial tears and lubrication, protective barriers (scleral lens, tarsorrhaphy), and growth factors that promote healing (serum tears, amniotic membrane). Finally, treatment can target restoration of corneal sensory innervation (cenegermin, corneal neurotization). Early recognition and treatment are important factors in reducing vision loss and long-term complications from neurotrophic keratitis.
The Oedipus complex in fiction
Authors: Abou Adel Mohammed Ahmed
Published: June 2023

This study aims to know The Bookseller’s Notebooks intersects with The Hunchback of Notre Dame and Oedipus Rex. We analyze the novelist’s proficiency at expressing contemporary human issues innovatively and artistically, focusing on the emotional struggle between parents and children. In particular, the study sheds light on the emotional and social struggles suffered by a marginalized, despised, and rejected societal group, namely illegitimate children (foundlings). The study’s findings suggest that more comparative studies of intertextuality between non-local works of literature should be attempted. This way, literature and literary criticism may enhance our understanding of other’s cultures to facilitate acceptance and peaceful coexistence.
A sturgeon cartilage extracellular matrix-derived bioactive bioink for tissue engineering applications
Authors: Meng Xiaolin , Zhou Zheng , Chen Xin , Ren Feng , Zhu Wenxiang , Zhu Shuai , Liu Hairong
Published: June 2023

Three-dimensional (3D) bioprinting provides a promising strategy for tissue and organ engineering, and extracellular matrix (ECM)-derived bioinks greatly facilitate its applications in these areas. Decellularized sturgeon cartilage ECM (dSC-ECM)- derived bioinks for cartilage tissue engineering were fabricated with methacrylatemodified dSC-ECM (dSC-ECMMA) and sericin methacrylate (SerMA), which optimizedthe mechanical properties of their solidified hydrogels.dSC-ECM induces chondrocytes to form cell clusters and subsequently reduces their proliferation, but the proliferation of encapsulated chondrocytes was normal in solidified dSCECM-5 bioink samples, which contain 5 mg/mL dSC-ECMMA. Hence, this bioink was selected for further investigation. Lyophilized dSC-ECM-5 hydrogels showed connected pore microstructure, which is suitable for cell migration and nutrients transportation. ThisdSC-ECM-5 bioink exhibited high fidelity and good printability by testing via a 3D bioprinting system, and the chondrocytes loaded in printed hydrogel products were viable and able to grow, following incubation, in the cell culture medium. Solidified dSC-ECM-5 and SerMA bioinks loaded with chondrocytes were subcutaneously implanted into nude mice for 4 weeks to test the suitability of the bioink for cartilage tissue engineering. Compared to the SerMA bioink, the dSCECM-5 bioink significantly enhanced cartilage tissue regeneration and maturation in vivo, suggesting the potential of this bioink to be applied in cartilage tissue engineering in the future.
3D-printed biodegradable magnesium alloy scaffolds with zoledronic acid-loaded ceramic composite coating promote osteoporotic bone defect repair
Authors: Ran Zhaoyang , Wang Yan , Li Jiaxin , Xu Wenyu , Tan Jia , Cao Bojun , Luo Dinghao , Ding Yiwen , Wu Junxiang , Wang Lei , Xie Kai , Deng Liang , Fu Penghuai , Sun Xiaoying , Shi Liyi , Hao Yongqiang
Published: June 2023

Osteoporotic fracture is one of the most serious complications of osteoporosis. Most fracture sites have bone defects, and restoring the balance between local osteogenesis and bone destruction is difficult during the repair of osteoporotic bone defects. In this study, we successfully fabricated three-dimensional (3D)-printed biodegradable magnesium alloy (Mg-Nd-Zn-Zr) scaffolds and prepared a zoledronic acid-loaded ceramic composite coating on the surface of the scaffolds. The osteogenic effect of Mg and the osteoclast inhibition effect of zoledronic acid were combined to promote osteoporotic bone defect repair. In vitro degradation and drug release experiments showed that the coating significantly reduced the degradation rate of 3D-printed Mg alloy scaffolds and achieved a slow release of loaded drugs. The degradation products of drug-loaded coating scaffolds can promote osteogenic differentiation of bone marrow mesenchymal stem cells as well as inhibit the formation of osteoclasts and the bone resorption by regulating the expression of related genes. Compared with the uncoated scaffolds, the drug-coated scaffolds degraded at a slower rate, and more new bone grew into these scaffolds. The healing rate and quality of the osteoporotic bone defects significantly improved in the drug-coated scaffold group. This study provides a new method for theoretical research and clinical treatment using functional materials for repairing osteoporotic bone defects.
The influence of the genotype and respiratory tract microflora on lung function and nutritional status in adult cystic fibrosis patients in long-term follow-up
Authors: Titova O. N. , Makhmutova V. R. , Gembitskaya T. E. , Chermensky A. G. , Stepanenko T. A. , Shklyarevich N. A.
Published: June 2023

In recent years, an increase in the number of patients with chronic infection with nonfermenting gram-negative bacteria (NFGNB) in adult patients with cystic fibrosis (CF) has increased. The genotype and phenotype characteristics, NFGNB structure, changes in sensitivity and the development of antibiotic resistance in adult patients have not been adequately studied.

Aim. To determine the impact of genotype severity and Achromobacter xylosoxidans sensitivity to carbapenems on the functional and nutritional status of adult cystic fibrosis patients over a period 2016 – 2021.

Materials. Retrospective analysis of genotypic and microbiological data from 54 adult CF patients and their effects on FEV1 and BMI over a period 2016 – 2021. Sputum cultures were confirmed by MALDI-TOF mass spectrometer. Depending on the severity of the mutation, the patients were divided into 2 groups: group 1 (“severe” genotype) – patients who had 2 mutations of class I – III; group 2 (“soft” genotype) – at least 1 class IV – VI mutation.

Results. The group of patients with “mild” mutations had a higher BMI (kg / m2) than the group with severe mutations for a longer period of follow-up from 2018 – 2021 than in the group with severe mutations: BMI (2016) – 21.14 ± 3.55 / 19.28 ± 3.13 (p = 0.163); BMI (2017) – 21.27 ± 3.43 / 18.31 ± 2.05 (p = 0.123); BMI (2018) – 21.17 ± 4.00 / 18.80 ± 2.12 (p = 0.025); BMI (2019) – 21.01 ± 4.20 / 18.55 ± 2.53 (p = 0.049); BMI (2020) – 20.94 ± 4.12 / 18.41 ± 2.15 (p = 0.050). Age at diagnosis was 20.36 ± 2.18 years for “mild” genotypes and was higher (p = 0.042) than for “severe” genotypes (6.27 ± 1.53 years). All 7 patients who died (100%) were in the “severe” genotype group (23.3%). Functional status assessment showed no differences in FEV1 over 6 years between the “severe” and “mild” genotype groups: FEV1 (2016) – p = 0.51; FEV1 (2017) – p = 0.39; FEV1 (2018) – p = 0.51; FEV1 (2019) – p = 0.35; FEV1 (2020) – p = 0.48. Nonfermenting Gram-negative bacteria accounted for 49.9% of the isolated microorganisms. The group of carbapenem-resistant Achromobacter xylosoxidans lost the FEV1 level faster every year for 6 years (p < 0.05) compared to the group of the sensitive variant.

Conclusion. In general, patients with the “mild” genotype have higher nutritional status and do not differ from patients with the “severe” genotype in terms of FEV1. The survival rate of patients with the “mild” genotype patients survival rate is higher, despite the later diagnosis and start of treatment. Development of carbаpenem resistance in Achromobacter xylosoxidans is associated with an unfavorable prognosis of the functional status decline.