bluuebunny/crossref_metadata_2025 huggingface dataset:
The transfusion service laboratory in virtual reality
Authors: Tsang Hamilton C. , Truong Jessica , Morse Ryan J. , Hasan Rida A. , Lieberman Joshua A.
Published: January 2022

Due to the global SARS‐CoV‐2 pandemic, in‐person laboratory medicine clerkships were converted to distance learning. The remote clerkship format provided advantages of allowing participation of students from more locations and greater scheduling flexibility but provided new challenges of maintaining learner engagement and providing experiential content of the laboratory environment. Gamification of educational content is one educational modality that has shown effectiveness in a multitude of different contexts to increase learner engagement and retention. Therefore, we created an interactive, educational 360° virtual reality walkthrough tour using off‐the‐shelf commercially available 360° cameras and software of the Transfusion service and Microbiology Laboratories. The process consists of taking multiple 360° still‐images within the space, color‐correction, blurring the faces of staff or sensitive information, adding navigation buttons, and other interactive elements. The virtual tours were used for both recruitment and education with further plans to integrate the learning modality into the curriculum. The clerkship is likely to remain as partially or fully as remote learning so such walkthrough tours will continue to remain relevant. This technology can be applied globally to other departments and institutions for education or recruitment.
Are convalescent plasma stocks collected during former COVID‐19 waves still effective against current SARS‐CoV‐2 variants?
Authors: Focosi Daniele , Franchini Massimo , Joyner Michael J. , Casadevall Arturo
Published: January 2022

COVID‐19 convalescent plasma (CCP) was among the few frontline therapies used to treat COVID‐19. After large randomized controlled trials (RCTs) relying on late use in hospitalized patients and/or low antibody titres failed to meet their predefined primary endpoint, the infectious disease community reduced usage of CCP in favour of monoclonal antibodies. Consequently, there are CCP stocks at most transfusion centres worldwide, although scattered usage continues. Further, better designed RCTs are also being launched. The urgent question here is: should we use CCP units collected months before given the largely changed viral variant landscape? We review here in vitro evidence that discourages usage of such CCP units against Delta and other variants of concern. CCP collections should be continued in order to update the armamentarium of therapeutics against vaccine breakthrough infections or in unvaccinated patients and is especially relevant in next‐generation RCTs.
Comparison between T2‐weighted two‐dimensional and three‐dimensional fast spin‐echo MRI sequences for characterizing thoracolumbar intervertebral disc disease in small‐breed dogs
Authors: Lee Suhyeon , Hwang Jeongyeon , Ko Jaeeun , Jeong Jeongyun , Eom Kidong , Kim Jaehwan
Published: January 2022

Magnetic resonance imaging (MRI) is a standard test for diagnosis and treatment planning in dogs with degenerative thoracolumbar intervertebral disc disease (IVDD). However, published studies evaluating three‐dimensional fast‐spin echo (3D‐FSE) pulse sequences for dogs with IVDD are currently limited. Aims of this retrospective, observational study were to compare findings from T2‐weighted two‐ and three‐dimensional fast spin‐echo sequences (2D‐ and 3D‐FSE, respectively) for a group of small breed dogs with thoracolumbar IVDD. Inclusion criteria were dogs with IVDD that underwent 1.5‐Tesla MRI using both 2D‐FSE and 3D‐FSE sequences. For each dog and sequence, five pathologic indices were recorded: epidural fat discontinuation, vertebral canal compromise, spinal cord signal change, disc degeneration, and nerve root compression. Two independent investigators also scored visibility of the facet joint, intervertebral foramen, nerve roots, spinal cord grey‐white matter differentiation, intervertebral discs, and epidural fat. The Wilcoxon signed‐rank test was used to evaluate the between‐sequence differences in pathologic indices and visibility scores. Interobserver agreement was measured using Cohen's weighted kappa along with 95% confidence intervals. A total of 21 dogs were sampled. The 3D‐FSE sequences had higher pathologic indices of vertebral canal compromise (P = 0.020) and spinal cord signal change (P = 0.046) than 2D‐FSE sequences. Furthermore, 3D‐FSE sequences had higher visibility scores for the facet joint, intervertebral foramen, and nerve root structures (P < 0.001). Findings from the current supported the use of 3D‐FSE sequences over 2D‐FSE sequences for the evaluation of IVDD and visualization of spinal structures in small breed dogs.
Working Through Colonial Collections
Authors: von Oswald Margareta
Published: January 2022

What are the possibilities and limits of engaging with colonialism in ethnological museums? This book addresses this question from within the Africa department of the Ethnological Museum in Berlin. It captures the Museum at a moment of substantial transformation, as it prepared the move of its exhibition to the Humboldt Forum, a newly built and contested cultural centre on Berlin’s Museum Island. The book discusses almost a decade of debate in which German colonialism was negotiated, and further recognised, through conflicts over colonial museum collections. Based on two years of ethnographic fieldwork examining the Museum’s various work practices, this book highlights the Museum’s embeddedness in colonial logics and shows how these unfold in the Museum’s everyday activity. It addresses the diverse areas of expertise in the Ethnological Museum – the preservation, storage, curation, and research of collections – and also draws on archival research and oral history interviews with current and former employees. Working through Colonial Collections unravels the ongoing and laborious processes of reckoning with colonialism in the Ethnological Museum’s present – processes from which other ethnological museums, as well as Western museums more generally, can learn.
This Obscure Thing Called Transparency
Authors: Alloa Emmanuel
Published: January 2022

Transparency is the metaphor of our time. Whether in government or corporate governance, finance, technology, health or the media – it is ubiquitous today, and there is hardly a current debate that does not call for more transparency. But what does this word actually stand for and what are the consequences for the life of individuals? Can knowledge from the arts, and its play of visibility and invisibility, tell us something about the paradoxical logics of transparency and mediation? This Obscure Thing Called Transparency gathers contributions by international experts who critically assess the promises and perils of transparency today.
A Novel Approach to Configuration Redesign: Using Multiobjective Monotonicity Analysis to Alter the Pareto Set
Authors: Sigurdarson Nökkvi S. , Eifler Tobias , Ebro Martin , Papalambros Panos Y.
Published: January 2022

Configuration (or topology or embodiment) design remains a ubiquitous challenge in product design optimization and in design automation, meaning configuration design is largely driven by experience in industrial practice. In this article, we introduce a novel configuration redesign process founded on the interaction of the designer with results from rigorous multiobjective monotonicity analysis. Guided by Pareto set dependencies, the designer seeks to reduce trade-offs among objectives or improve optimality overall, deriving redesigns that eliminate dependencies or relax active constraints. The method is demonstrated on an ingestible medical device for oral drug delivery, currently in early concept development.
Machine Learning for the Development of Data-Driven Turbulence Closures in Coolant Systems
Authors: Hammond James , Montomoli Francesco , Pietropaoli Marco , Sandberg Richard D. , Michelassi Vittorio
Published: January 2022

This work shows the application of Gene Expression Programming to augment RANS turbulence closures for flows though complex geometries. Specifically, an optimized internal cooling channel of a turbine blade, designed for additive manufacturing. One of the challenges in internal cooling design is the heat transfer accuracy of the RANS formulation in comparison to higher fidelity methods, which are still not used in design on account of their computational cost. However, high fidelity data can be extremely valuable for improving current lower fidelity models and this work shows the application of data-driven approaches to develop turbulence closures for an internally ribbed duct. Different approaches are compared and the results of the improved model are illustrated; first on the same geometry, and then for an unseen predictive case.

The work shows the potential of using data-driven models for accurate heat transfer predictions even in non-conventional configurations and indicates the ability of closures learnt from complex flow cases to adapt successfully to unseen test cases.
The Role of an Actual Brand Positioning: An Analysis of Digital Advertisements
Authors: Won June , Lee J. Lucy
Published: January 2022

The purpose of this study was to: (a) investigate the actual positions in digital communications; (b) assess the relationship between position-congruity among intended positions (i.e., how a firm desires to be perceived by consumers), actual brand positions, and perceived brand positions (i.e., the perceptions that customers have in their minds); and (c) understand the role of actual positioning (AP) in the positioning process. Multiple methods (one-on-one and focus group interviews, content analysis) were applied to analyze positions. Brand managers, golf consumers, and digital advertisements in Golf Digest magazine were sampled. Content analysis, frequencies and percentages, percentage difference, and regression analysis were performed for all positions for each research brand. The results revealed that: (a) tangibility-based positions (88.5%: great quality, innovation) outnumbered intangibility-based ones (11.5%: tour performance, tradition) in digital AP, (b) there was no positive correlation between the degree of congruence between intended and AP and the degree of congruence between intended and perceived positioning, and (c) the AP mediated between intended and perceived positioning in the brand positioning model. The study provides empirical evidence for the mediating role of AP and suggests modifications to the previous positioning process.
Draft Genome Sequence of the Polychlorinated Biphenyl Degrader Comamonas testosteroni Strain YAZ2, Isolated from a Natural Landscape in the Tohoku Region of Japan
Authors: Hara Tomijiro , Takatsuka Yumiko , Shiwa Yuh , Yokota Kenji
Published: January 2022

We report a draft genome sequence of
Comamonas testosteroni
strain YAZ2, a polychlorinated biphenyl (PCB) degrader that was isolated from a PCB-unpolluted environment. The assembled genome contains a single 5.4-Mb chromosome and an 87-kb plasmid. The
bph
gene cluster, which is involved in PCB degradation, was found on the chromosome.
Draft Genome Sequence of Bifidobacterium adolescentis 4-2, Isolated from Healthy Human Feces
Authors: Altaib Hend , Niwa Ryo , Abe Mayuko , Suzuki Tohru
Published: January 2022

Bifidobacterium adolescentis
4-2 was isolated from healthy human feces. Here, we report a draft genome sequence of this bacterium, which may clarify the functionality of gut microbiota-brain communication. The draft genome comprises 2.39 Mb, with an average G+C content of 59.2% and 2,028 coding DNA sequences. An operon for GABA biosynthesis was observed in the draft genome.
Bifidobacterium
-Escherichia coli Shuttle Vector Series pKO403, with Temperature-Sensitive Replication Origin for Gene Knockout in
Bifidobacterium
Authors: Altaib Hend , Ozaki Yuka , Kozakai Tomoya , Sakaguchi Kouta , Nomura Izumi , Suzuki Tohru
Published: January 2022

A series of
Bifidobacterium
-
Escherichia coli
shuttle vectors (pKO403-
lacZ′
-Cm, pKO403-
lacZ′
-Sp, pKO403-
lacZ′
-p15A) were constructed based on the pKO403 backbone, which carries a temperature-sensitive replication origin. These vectors carry the
lacZ′
α fragment, overhung by two facing type IIS restriction sites, for blue-white selection and seamless gene cloning.
Draft Whole-Genome Sequences of Two Multidrug-Resistant Salmonella enterica Serovar Senftenberg Sequence Type 14 Strains Resistant to Ciprofloxacin, Ceftriaxone, and/or Azithromycin, Isolated from Kolkata, India
Authors: Jain Priyanka , Viswanathan Rajlakshmi , Halder Gourab , Basu Sulagna , Dutta Shanta
Published: January 2022

We report draft whole-genome sequences of two multidrug-resistant
Salmonella enterica
serovar Senftenberg sequence type 14 strains resistant to ciprofloxacin, ceftriaxone, and/or azithromycin, which were isolated from neonatal stool and goat meat in Kolkata, India. The genome characteristics, as well as the antimicrobial resistance genes, plasmid types, and integrons, are presented in this report.
Supplemental Material: A robust age model for the Cryogenian Pocatello Formation of southeastern Idaho (northwestern USA) from tandem in situ and isotope dilution U-Pb dating of volcanic tuffs and epiclastic detrital zircons
Authors: Isakson V.H. , al. et , Schmitz M.D.
Published: January 2022

Figure S1. Thin-section photomicrographs for lithologies of the Bannock Volcanic Member and Scout Mountain Member of the Pocatello Formation exposed at Scout Mountain, Idaho. Sample numbers are illustrated on the stratigraphic section of Figure 4. Field of view is 24 mm × 40 mm. Tables S1–S3: LA-ICPMS U-Pb isotope and trace element concentration data. Table S4: CA-IDTIMS U-Pb isotope data.
Supplemental Material: Modern-like elevation and climate in Tibet since the mid-Miocene (ca. 15 Ma)
Authors: Xu Qiang , Li Shun , al. et
Published: January 2022

Geochronologic and paired stable isotopic data from the upper Gazhacun Formation of the Namling Basin in southern Tibet.
Indirect effects of the covid-19 pandemic on childhood infection in England: population based observational study
Authors: Kadambari Seilesh , Goldacre Raphael , Morris Eva , Goldacre Michael J , Pollard Andrew J
Published: January 2022

Objective

To assess the impact of the covid-19 pandemic on hospital admission rates and mortality outcomes for childhood respiratory infections, severe invasive infections, and vaccine preventable disease in England.

Design

Population based observational study of 19 common childhood respiratory, severe invasive, and vaccine preventable infections, comparing hospital admission rates and mortality outcomes before and after the onset of the pandemic in England.

Setting

Hospital admission data from every NHS hospital in England from 1 March 2017 to 30 June 2021 with record linkage to national mortality data.

Population

Children aged 0-14 years admitted to an NHS hospital with a selected childhood infection from 1 March 2017 to 30 June 2021.

Main outcome measures

For each infection, numbers of hospital admissions every month from 1 March 2017 to 30 June 2021, percentage changes in the number of hospital admissions before and after 1 March 2020, and adjusted odds ratios to compare 60 day case fatality outcomes before and after 1 March 2020.

Results

After 1 March 2020, substantial and sustained reductions in hospital admissions were found for all but one of the 19 infective conditions studied. Among the respiratory infections, the greatest percentage reductions were for influenza (mean annual number admitted between 1 March 2017 and 29 February 2020 was 5379 and number of children admitted from 1 March 2020 to 28 February 2021 was 304, 94% reduction, 95% confidence interval 89% to 97%), and bronchiolitis (from 51 655 to 9423, 82% reduction, 95% confidence interval 79% to 84%). Among the severe invasive infections, the greatest reduction was for meningitis (50% reduction, 47% to 52%). For the vaccine preventable infections, reductions ranged from 53% (32% to 68%) for mumps to 90% (80% to 95%) for measles. Reductions were seen across all demographic subgroups and in children with underlying comorbidities. Corresponding decreases were also found for the absolute numbers of 60 day case fatalities, although the proportion of children admitted for pneumonia who died within 60 days increased (age-sex adjusted odds ratio 1.71, 95% confidence interval 1.43 to 2.05). More recent data indicate that some respiratory infections increased to higher levels than usual after May 2021.

Conclusions

During the covid-19 pandemic, a range of behavioural changes (adoption of non-pharmacological interventions) and societal strategies (school closures, lockdowns, and restricted travel) were used to reduce transmission of SARS-CoV-2, which also reduced admissions for common and severe childhood infections. Continued monitoring of these infections is required as social restrictions evolve.
Rapid introduction of virtual consultation in a hospital-based Consultant-led Antenatal Clinic to minimise exposure of pregnant women to COVID-19
Authors: Tavener Christina Rose , Kyriacou Christopher , Elmascri Imene , Cruickshank Amy , Das Sabrina
Published: January 2022

The COVID-19 global pandemic dictated rapid change to outpatient services within our London-based maternity hospital. Coupled with long waiting times in the Consultant-led Antenatal clinic, we aimed to reduce hospital footfall and unnecessary contact with a clinically vulnerable patient population by reducing face-to-face consultations. Numerous specialties have already successfully implemented safe and effective teleconferencing, allowing remote review while reducing the risks posed by face-to-face contact. A target to see at least 15% of women remotely was set to reduce footfall in the Consultant-led Antenatal Clinic. We aimed to reduce face-to-face waiting times to a mean of 30 min. In March 2020, clinics were prevetted by the clinic consultant to carefully select appropriate women suitable for video or telephone consultations. Clinic templates were changed, increasing appointment times by 5–25 min each. ‘AccuRx’ software was tested and used to communicate appointment details and conduct the consultation. In-person waiting times in the clinic and number of virtual consultations over a 3-month period was recorded, along with qualitative feedback from service users and staff through surveys and departmental meetings. Mean waiting times were reduced by 33% from 45–30 min and multiple service-user benefits were noted, including partner involvement, convenience of waiting for appointments at home and removing requirement for childcare. However, limitations of internet connectivity, need for time to prevet clinics and lack of a robust administration system to inform women of their appointment type were highlighted. Further work is required in these areas to ensure sustainability and improvement of this process for the future.
Large-scale manufacturing and characterization of CMV-CD19CAR T cells
Authors: Wang Xiuli , Urak Ryan , Walter Miriam , Guan Min , Han Tianxu , Vyas Vibhuti , Chien Sheng-Hsuan , Gittins Brenna , Clark Mary C , Mokhtari Sally , Cardoso Angelo , Diamond Don J , Zaia John , Forman Stephen J , Nakamura Ryotaro
Published: January 2022

Background

Adoptive transfer of CD19-specific chimeric antigen receptor (CD19CAR) T cells can induce dramatic disease regression in patients with B cell malignancies. CD19CAR T cell therapy may be limited by insufficient engraftment and persistence, resulting in tumor relapse. We previously demonstrated a proof of principle that cytomegalovirus (CMV)-specific T cells can be isolated and enriched prior to CD19CAR transduction to produce CMV-CD19CAR T cells, and that these CMV-CD19CAR T cells can be expanded in vivo through CMV vaccination, resulting in better tumor control in a murine model. Here we developed a clinical platform for generating CMV-CD19CAR T cells.

Methods

Peripheral blood mononuclear cells (PBMCs) collected from CMV-seropositive healthy donors were stimulated with a good manufacturing practices-grade PepTivator overlapping CMVpp65 peptide pool and enriched for CMV-responsive interferon γ (IFNγ)+T cells using IFNγ Catchmatrix, within the CliniMACS Prodigy Cytokine Capture System (Miltenyi Biotec). Resulting CMV-specific T cells were transduced with a lentiviral vector encoding a second generation CD19R:CD28:ζ/EGFRt CAR and expanded with interleukin 2 (IL-2) and IL-15 for 15 days before characterization.

Results

CMV-specific T cells were enriched from 0.8%±0.5 of input PBMC to 76.3%±11.6 in nine full-scale qualification runs (absolute yield of 4.2±3.3×106IFNγ+T cells from an input of 1×109PBMCs). Average CD19CAR transduction efficiency of CMV-specific T cells was 27.0%±14.2 in the final products, which underwent rapid expansion, resulting in a total cell dose of 6.2±0.9 × 106CD19CAR-tranduced T cells with CMV specificity (ie, functionally bispecific). CMV-CD19CAR T cells were polyclonal, expressed memory markers but had low expression of exhaustion markers, responded to both CD19 and CMVpp65 stimulation with rapid proliferation and exhibited antigen-specific effector functions against both CD19-expressing tumors and CMVpp65 antigen. The final products passed release criteria for clinical use.

Conclusions

We demonstrated the feasibility of our large-scale platform for generating CMV-CD19CAR T cells for clinical application. We plan to initiate a clinical trial at City of Hope using CMV-CD19CAR T cells for patients with intermediate/high-grade B cell non-Hodgkin’s lymphoma immediately after autologous hematopoietic cell transplantation followed by vaccination with a novel CMV vaccine based on Modified Vaccinia Ankara (Triplex) 28 days and 56 days post-T cell infusion.
Motion-induced energy shifts of a multilevel atom in a black-body radiation field
Authors: Cai Huabing , Wang Li-Gang
Published: January 2022

We investigate the influence of atomic uniform motion on radiative energy shifts of a multilevel atom when it interacts with black-body radiation. Our analysis reveals that the atomic energy shifts depend crucially on three factors: the temperature of black-body thermal radiation, atomic velocity, and atomic polarizability. In the low-temperature limit, the presence of atomic uniform motion always enhances the effect of the thermal field on the atomic energy shifts. However, in the high-temperature limit, the atomic uniform motion enhances the effect of the thermal field for an atom polarizable perpendicular to the atomic velocity but weakens it for an atom polarizable parallel to the atomic velocity. Our work indicates that the physical properties of atom–field coupling systems can in principle be regulated and controlled by the combined action of the thermal field and the atomic uniform motion.
Research on Integrated Decision Control Algorithm for Autonomous Vehicles Under Multi-Task Hybrid Constraints in Intelligent Transportation Scenarios
Authors: Guo Zonghuan , Sun Dihua , Zhou Lin
Published: January 2022

In order to improve the decision-making and control effect of autonomous vehicles, in this paper, combined with literature research and process analysis, the control algorithm of autopilot vehicle is analyzed, and the driving process is analyzed combined with the flow method. In order to improve the effect of autonomous driving, with the support of improved algorithms, an integrated decision-making control system for autonomous vehicles under multi-task constraints in intelligent traffic scenarios is constructed, and system performance is improved by simulating autonomous driving decisions in a variety of complex situations. Moreover, this paper designs the road driving model according to actual needs, sets the functional modules of the entire system, and build the overall framework of the system. Finally, in order to study the integrated decision-making effect of this system, this paper conducts test research by designing a simulation test method. From the simulation test results, it can be seen that the intelligent decision-making system for autonomous vehicles constructed in this paper has certain effects.
INVESTIGATION ON THE MORPHOLOGICAL AND THERMAL PROPERTIES OF POLYLACTIC ACID/POLYCAPROLACTONE LOADED WITH HALLOYSITE NANOTUBES AND BASALT FIBER
Authors: KUMAR A. ARUL JEYA , RAJ NIRANJAN S. , SAIPRASAD C. , SUDHANVA AGHALAYAM R.
Published: January 2022

This paper is focused on the analysis of the morphological and thermal properties of the biomedical composites, polylactic acid (PLA) and polycaprolactone (PCL) matrix, reinforced with basalt fibers (BFs) and using halloysite nanotubes (HNT) as filler material. Four different composites, viz. PPHB 1, PPHB 2, PPHB 3 and PPHB 4, are obtained by varying the weight fractions of these materials using twin-screw extrusion followed by injection molding. The morphological characterization is performed on these composites using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. SEM reveals homogenous and strong bonding between the matrix, reinforcement and filler. The BF are well embedded in the matrix with a random orientation. No formation of voids and cracks is observed. The functional groups present and the types of vibration experienced by the chemical bonds were observed in the FTIR spectra. The composites are subjected to thermal testing such as differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The PPHB 2, which contains 80% PLA, 10% BF, 7% PCL and 3% HNT, has the highest degree of crystallinity, as revealed by DSC, and exhibits the most optimum thermal degradation characteristics as indicated by TGA.
Open Frobenius Cluster-Tilted Algebras
Authors: Gubitosi Viviana
Published: January 2022

In this paper, we compute the Frobenius dimension of any cluster-tilted algebra of finite type. Moreover, we give conditions on the bound quiver of a cluster-tilted algebra [Formula: see text] such that [Formula: see text] has non-trivial open Frobenius structures.
New Results on EP Elements in Rings with Involution
Authors: Wang Long , Mosić Dijana , Gao Yuefeng
Published: January 2022

In this paper, we mainly give characterizations of EP elements in terms of equations. In addition, a related notion named a central EP element is defined and investigated. Finally, we focus on characterizations of a generalized EP element, i.e., [Formula: see text]-DMP element.
Classical Radicals of Invariants of Algebraic Skew Derivations
Authors: Bergen Jeffrey , Grzeszczuk Piotr
Published: January 2022

Let [Formula: see text] be an automorphism and[Formula: see text] be a [Formula: see text]-skew [Formula: see text]-derivation of an [Formula: see text]-algebra [Formula: see text]. We prove that if [Formula: see text] is semiprimitive and [Formula: see text] is algebraic, then the subalgebra [Formula: see text] has nilpotent Jacobson radical. Using this result, we obtain similar relations for the Baer prime radical, the Levitzki locally nilpotent radical, and the Köthe nil radical when the field [Formula: see text] is uncountable. Then we apply it to actions of the [Formula: see text]-dimensional Taft Hopf algebra [Formula: see text] and the [Formula: see text]-analogue [Formula: see text] of the enveloping algebra of the Lie algebra [Formula: see text].
Some Results on Noetherian Warfield Domains
Authors: Hu Kui , Lim Jung Wook , Zhou Dechuan
Published: January 2022

Let [Formula: see text] be a domain. In this paper, we show that if [Formula: see text] is one-dimensional, then [Formula: see text] is a Noetherian Warfield domain if and only if every maximal ideal of [Formula: see text] is 2-generated and for every maximal ideal[Formula: see text] of [Formula: see text], [Formula: see text] is divisorial in the ring [Formula: see text]. We also prove that a Noetherian domain [Formula: see text] is a Noetherian Warfield domain if and only if for every maximal ideal [Formula: see text] of [Formula: see text], [Formula: see text] can be generated by two elements. Finally, we give a sufficient condition under which all ideals of [Formula: see text] are strongly Gorenstein projective.
Efficient Detection of Gastric Cancer Marker miR-185 Using Graphene Oxide and Nuclease DSN
Authors: Li Sen , Yin Shaoxian , Fu Qisheng , Chen Yuanyuan , Cai Yanfei , Yang Zhaoqi
Published: January 2022

Since miR-185 has been identified as a prognostic biomarker to forecast the course of survival and relapse in gastric cancer (GC), quantitative detection of miR-185 features in developing personalized strategies for GC treatment. In this study, a highly sensitive method for miR-185 detection was rationally designed with the characteristic of fluorescent signal amplification and it was based on constructing graphene oxide sensor and utilizing duplex specific nuclease (DSN). In detail, the cleavage of many DNA signal probes was successfully triggered by the miR-185 target which contributed to the target-recycling mechanism. The protocol exhibited a prominent ability to analyze miR-185 in solution, and it can detect miR-185 at different concentrations as low as 476 pM with a linear range of 0–50 nM. Moreover, this method has gained its prominence in distinguishing the target miRNA from various sequences with one to three base mismatches or other miRNAs. Taken together, it presented the prominent potential to be a candidate tool in the field of clinical diagnosis considering its precise and efficient ability to detect miR-185.
Rees matrix seminearring
Authors: Pal Pavel , Mukherjee Rajlaxmi , Ghosh Manideepa
Published: January 2022

As a continuation of the work done in (R. Mukherjee (Pal), P. Pal and S. K. Sardar, On additively completely regular seminearrings, Commun. Algebra  45 (12) (2017) 5111–5122), in this paper, our objective is to characterize left (right) completely simple seminearrings in terms of Rees Construction by generalizing the concept of Rees matrix semigroup (J. M. Howie, Fundamentals of Semigroup Theory (Clarendon Press, Oxford, 1995); M. Petrich and N. R. Reilly, Completely Regular Semigroups (Wiley, New York, 1999)) and that of Rees matrix semiring (M. K. Sen, S. K. Maity and H. J. Weinert, Completely simple semirings, Bull. Calcutta Math. Soc.  97 (2005) 163–172). In Rees theorem, a completely simple semigroup is coordinatized in such a way that each element can be seen to be a triplet which gives this abstract structure a much more simpler look. In this paper, we have been able to construct a similar kind of coordinate structure of a restricted class of left (right) completely simple seminearrings taking impetus from (M. P. Grillet, Semirings with a completely simple additive semigroup, J. Austral. Math. Soc.  20 (Ser. A) (1975) 257–267, Theorem [Formula: see text] and (M. K. Sen, S. K. Maity and H. J. Weinert, Completely simple semirings, Bull. Calcutta Math. Soc.  97 (2005) 163–172, Theorem 3.1).
MRI in Axial Spondyloarthritis: Position Statements from the Hong Kong Society of Rheumatology
Authors: Chung Ho Yin , Wong Priscilla Ching Han , Lee Kam Ho , Ciang Natalia Chu-Oi , Wong Stella Pui Yan , Cao Peng , Chan Shirley Chiu Wai , Lau Vince Wing Hang , Lo Bill Archie , Lee Ryan Ka Lok ,   the Hong Kong Society of Rheumatology
Published: January 2022

The Hong Kong Society of Rheumatology (HKSR) has developed evidence-based position statements on the use of magnetic resonance imaging (MRI) in axial spondyloarthritis (axSpA). A special interest group (SIG) developed the statements based on the literature review of the following research questions: 1) In whom should SI joint MRI be done to diagnose axSpA? 2) Should spine MRI be performed for diagnosis of axSpA? 3) Should spine and SI joint MRI be used in the assessment and monitoring of disease activity? 4) Which MRI sequence(s) should be used in axSpA? These statements have at least 75% agreement from voting rheumatology fellows of HKSR, and are developed to serve as local practice guidelines for rheumatologists and musculoskeletal radiologists in the management of axSpA.
Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle
Authors: Egawa Tatsuro , Ogawa Takeshi , Yokokawa Takumi , Kido Kohei , Goto Katsumasa , Hayashi Tatsuya
Published: January 2022

This study investigated the effect of methylglyoxal, which is a highly reactive carbonyl metabolite and has detrimental effects on the body, on skeletal muscle adaptations following endurance exercise. Evidences from this study show that methylglyoxal is a factor deteriorating responsiveness to endurance exercise in primarily fast-twitch skeletal muscle. The findings contribute to understand the internal factors that should be focused to maximize the exercise effects.
Power attenuation from restricting range of motion is minimized in subjects with fast RTD and following isometric training
Authors: Davidson Brooke , Hinks Avery , Dalton Brian H. , Akagi Ryota , Power Geoffrey A.
Published: January 2022

Power output was greater in the unrestricted than restricted ROM, and there were strong relationships between rate of torque development (RTD) and velocity development (RVD) with peak power. RTD and RVD had the strongest relationships with power when ROM was restricted and unrestricted, respectively. Following 8 wk of isometric training, discrepancies in power between restricted and unrestricted ROM were reduced. Increasing RTD through isometric training increased power in dynamic movements, especially when ROM was restricted.
Theranostic Effect of Folic Acid Functionalized MIL‐100(Fe) for Delivery of Prodigiosin and Simultaneous Tracking‐Combating Breast Cancer
Authors: Mokhtarian Fatemeh , Rastegari Banafsheh , Zeinali Sedigheh , Tohidi Maryam , Karbalaei-Heidari Hamid Reza
Published: January 2022

The metal organic framework (MOF) member, MIL‐100(Fe), is considered as attractive drug nanocarrier that may be due to the great porosity, colloidal stability, and biocompatibility. In the present study, the new electrochemical synthesis procedure was presented for MIL‐100(Fe) building block, and secondly, folic acid (FA) was introduced to the structure for assessing its potential targeted ability to be entrapped by folic acid‐positive breast cancer cells, MCF‐7. Several techniques such as SEM, XRD, and FT‐IR were used to characterize synthesized nanostructures. Both MIL‐100(Fe) and MIL‐100(Fe)/FA nanoparticles were between 50 to 200 nm with a slightly positive net charge with an area of 1350 and 831.84 m2/g, respectively. The prodigiosin (PG) is selected as a model drug for MIL‐100(Fe) and MIL‐100(Fe)/FA‐targeted delivery owing to its natural fluorescence and cancer cell selectiveness. The loading capacity of both nanocarrier was around 40% with 93‐97% loading efficacy. Moreover, the pH‐sensitive prodigiosin release rate of MIL‐100(Fe)@PG and MIL‐100(Fe)/FA@PG showed that 69 to 73% of the drug was released after 24 hours in an acidic environment with around 20% unwanted leakage. The anticancer potential MIL‐100(Fe)/FA cells showed the improvement of selective index (SI) from 3.21 to 12.48 which means that folic acid acts as an effective ligand. The study of cells treated with fluorescence microscopy and flow cytometry analysis reveals the dependence of the receptor on the nanoparticle through endocytosis. Considering the effects of nanoparticles on healthy cells, MIL‐100(Fe) and MIL‐100(Fe)/FA nanoparticles can be introduced as targeted drug delivery systems for smart targeting breast cancer cells with minimal side effects.
Expression of Killer Immunoglobulin Receptor Genes among HIV-Infected Individuals with Non-AIDS Comorbidities
Authors: Abou Hassan Farouk F. , Bou Hamdan Mirna , El Asmar Khalil , Melhem Nada M.
Published: January 2022

Combined antiretroviral therapy (cART) increased the life expectancy of people living with HIV (PLHIV) and remarkably reduced the morbidity and mortality associated with HIV infection. However, non-AIDS associated comorbidities including diabetes, hypertension, hyperlipidemia, and cardiovascular diseases (CVD) are increasingly reported among PLHIV receiving cART. Killer cell immunoglobulin receptors (KIRs) expressed on the surface of natural killer (NK) cells have been previously implicated in controlling HIV disease progression. The aim of this study is to investigate the role of KIRs in developing non-AIDS associated comorbidities among PLHIV. Demographic and behavioral data were collected from voluntary participants using a standardized questionnaire. Whole blood samples were collected for KIR genotyping. Hypertension (29.5%) and hyperlipidemia (29.5%) followed by diabetes (23.7%) and CVD (9.7%) were mainly reported among our study participants with higher rate of comorbid conditions observed among

participants
>
40

years old. The observed KIR frequency (OF) was ≥90% for inhibitory KIR2DL1 and KIR3DL1, activating KIR2DS4 and the pseudogene KIR2DP1 among study participants. We detected significant differences in the expression of KIR3DS4 and KIR3DL1 (

p
=
0.038

) between diabetic and nondiabetic and in the expression of KIR2DL3 between hypertensive and normotensive HIV-infected individuals (

p
=
0.047

). Moreover, KIR2DL1 and KIR2DP1 were associated with significantly reduced odds of having CVD (OR 0.08; 95% CI: 0.01-0.69;

p
=
0.022

). Our study suggests the potential role of KIR in predisposition to non-AIDS comorbidities among PLHIV and underscores the need for more studies to further elucidate the role of KIRs in this population.
Presentation of Novel Multiple Regression Model for Accounting Information Quality, Corporate Investment, and Moderating Role of Ownership Structure in Companies
Authors: Amiran Mahsa , Asadi Abdorreza , Oladi Maryam
Published: January 2022

The conflicts of interest between managers and shareholders force managers to make decisions that do not meet the interests of shareholders. One of these decisions is to invest less in the company’s operational activities. Increasing the information quality is one way to prevent that issue, allowing stakeholders to monitor investment decisions. The present study investigates the relation of accounting information quality, corporate investment, and ownership structure for Iranian firms, using panel data analysis from 2009 to 2018. We applied a multiple regression model to test the hypotheses. The results show that the quality of accounting information significantly affects the investment decision for the company’s main operations, so the first hypothesis of the research is confirmed. At the same time, there is no effect of capital structure on accounting information quality and firms’ investment decisions. Thus, the second hypothesis of the research failed to be confirmed.
Analysis of the Coupling Effect of Thermal and Traffic Loads on Cement Concrete Pavement with Voids Repaired with Polymer Grout
Authors: Cui Can , Lu Qing , Guo Chengchao , Wang Fuming
Published: January 2022

Under the repeated action of traffic and thermal loads, a cement concrete pavement slab may partially lose contact with its base course, and voids may develop underneath the slab. Such distress will greatly impact the pavement performance. To fill the voids and restore the base support to the slab, the technology of polymer grouting has been increasingly adopted in recent years due to its advantages of quick application and high efficiency. There is, however, a lack of research on the mechanistic responses and performance of such a repaired rigid pavement under coupled influences of thermal and traffic loads. Existing literature has mainly focused on normal cement concrete pavement structures (i.e., without polymer grouted voids). This study intends to fill the research gap by investigating the time-domain characteristics of thermal stress response of a cement concrete pavement with underlying voids filled with polymer grout, along with design traffic loads. The finite element method was adopted with a 3-dimensional nonlinear temperature field within the pavement. A program module was developed in the Abaqus FEA software environment for temperature effect analysis. It was found that under the coupling action of thermal and traffic loads, thermal stress had a greater influence on the critical slab stress at the slab corner than those at other slab locations. Through the comparative analysis before and after polymer grouting repair, the critical tensile stress at the slab corner under the vehicle and thermal loads can be effectively reduced. The polymer performance is stable after three years.
Vitamin D Supplementation for Prevention of Dental Implant Failure: A Systematic Review
Authors: Makke Alaa
Published: January 2022

Background. Many factors play a significant role in osseointegration and healing after dental implant insertion and restoration. Some factors are related to dental biomaterials, such as the dental implant, prosthesis, and grafting materials. Other factors can be connected to operator skills and accumulated experience. Local and systemic patient-related factors are crucial in determining the success of the dental implant. Thorough examination and analysis of local factors using available examination tools are vital to prepare the implant candidate for such treatment. The patient’s systemic condition directly affects the healing of the dental implant. One of the most overlooked systemic factors is the patients’ vitamin D level, which influences bone formation around the implant and subsequent osseointegration. The current review examined the available literature regarding the association between vitamin D supplementation and dental implant osseointegration. Methods. Data of this review were derived from recent research available on PubMed, Google Scholar, and Scopus. Inclusion criteria were the relation between the vitamin D serum and dental implant osseointegration or failure. The Systematic Reviews and Meta-Analyses (PRISMA) checklist was followed to perform the review. The study’s outcome was the need for vitamin D supplementation to prevent implant failure. Results. Five human studies (including case reports, case series, and retrospective studies) and six animal studies. All included studies discussed the relationship between vitamin D, early dental implant failure, and bone implant contact. Three retrospective studies found no significant relationship between vitamin D supplementation and EDIFs in humans. On the other hand, one retrospective study showed a significant relationship in humans. A case report and case series claimed that the implant was successfully placed after vitamin D supplementation. A total of four animal studies showed a significant relationship between vitamin D supplementation and osseointegration of the dental implant. Two animal studies showed no significant association. Conclusion. To ensure optimal treatment outcomes, it is recommended to supplement the patient with vitamin D if the serum level is not within the normal range. Further clinical studies and case reports are needed to confirm the association between serum vitamin D levels and osseointegration.
Nonlinear Viscoelastic‐Plastic Creep Model of Rock Based on Fractional Calculus
Authors: Wei Erjian , Hu Bin , Li Jing , Cui Kai , Zhang Zhen , Cui Aneng , Ma Liyao
Published: January 2022

A rock creep constitutive model is the core content of rock rheological mechanics theory and is of great significance for studying the long‐term stability of engineering. Most of the creep models constructed in previous studies have complex types and many parameters. Based on fractional calculus theory, this paper explores the creep curve characteristics of the creep elements with the fractional order change, constructs a nonlinear viscoelastic‐plastic creep model of rock based on fractional calculus, and deduces the creep constitutive equation. By using a user‐defined function fitting tool of the Origin software and the Levenberg–Marquardt optimization algorithm, the creep test data are fitted and compared. The fitting curve is in good agreement with the experimental data, which shows the rationality and applicability of the proposed nonlinear viscoelastic‐plastic creep model. Through sensitivity analysis of the fractional order β2 and viscoelastic coefficient ξ2, the influence of these creep parameters on rock creep is clarified. The research results show that the nonlinear viscoelastic‐plastic creep model of rock based on fractional calculus constructed in this paper can well describe the creep characteristics of rock, and this model has certain theoretical significance and engineering application value for long‐term engineering stability research.
Molecular Mechanism of Traditional Chinese Ointment of Xuzhou Qufu Shengji in Infected Wounds
Authors: Shen Jinhu , Li Chaoding , Zhang Lei , Sun Yan , Zhang Lin , Yang Liuzhong
Published: January 2022

Background. Xuzhou Qufu Shengji Ointment (QFSJO) has been used in hospital and private medication for more than 30 years to treat the infective wounds after trauma. However, molecular investigation is lacking. This study used rats to explore the healing mechanism of QFSJO in promoting wound healing in human. Methods. One circular incision was individually generated on the back of 30 rats in three groups and challenged with 108 CFU (0.3 mL) of Staphylococcus aureus. Then, one of the trauma groups was treated with QFSJO gauze, and the control group was covered with a piece of Vaseline gauze, while the western medicine group was treated with erythromycin in a similar way. The dressing change of all the groups was performed once a day for three weeks. The anti-inflammation and proangiogenesis of QFSJO were evaluated by enzyme-linked immunosorbent assay (ELISA). The levels of angiogenesis associated factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF), hydroxyproline, and hemoglobin, were measured according to ELISA. The immunohistochemistry of CD31 and CD34 expression in granulation tissue was demonstrated and quantitatively analyzed for angiogenesis in granulation tissue in sites. Results. A faster wound healing ratio was observed in QFSJO-dressing-treated group than Vaseline- and erythrocin-treated groups. ELISA results showed that QFSJO promoted VEGF and b-FGF levels significantly in early stage of wound healing. QFSJO dressing group also showed an enhanced hydroxyproline and hemoglobin in granulation tissue. The expressions of CD31 and CD34 in granulation tissue of QFSJO group were higher than in the Vaseline and erythrocin groups. Conclusion. QFSJO improved the healing rate of the infective wounds by promoting the angiogenesis of granulation tissue and inhibiting the inflammation of the trauma tissue. Our finding suggests that QFSJO is able to help angiogenic capillary sprouts for collagen accumulates in the granulation tissue.
The Emerging Role of c-Met in Carcinogenesis and Clinical Implications as a Possible Therapeutic Target
Authors: Faiella Antonio , Riccardi Ferdinando , Cartenì Giacomo , Chiurazzi Martina , Onofrio Livia
Published: January 2022

Background. c-MET is a receptor tyrosine kinase receptor (RTK) for the hepatocyte growth factor (HGF). The binding of HGF to c-MET regulates several cellular functions: differentiation, proliferation, epithelial cell motility, angiogenesis, and epithelial-mesenchymal transition (EMT). Moreover, it is known to be involved in carcinogenesis. Comprehension of HGF-c-MET signaling pathway might have important clinical consequences allowing to predict prognosis, response to treatment, and survival rates based on its expression and dysregulation. Discussion. c-MET represents a useful molecular target for novel engineered drugs. Several clinical trials are underway for various solid tumors and the development of new specific monoclonal antibodies depends on the recent knowledge about the definite c-MET role in each different malignance. Recent clinical trials based on c-MET molecular targets result in good safety profile and represent a promising therapeutic strategy for solid cancers, in monotherapy or in combination with other target drugs. Conclusion. The list of cell surface receptors crosslinking with the c-MET signaling is constantly growing, highlighting the importance of this pathway for personalized target therapy. Research on the combination of c-MET inhibitors with other drugs will hopefully lead to discovery of new effective treatment options.