bluuebunny/crossref_metadata_2025 huggingface dataset:
GhMYB102 affects cotton fibre elongation and secondary wall thickening by regulating GhIRX10 in cotton
Authors: Wu Aimin , Shen Tong , Lu Jianhua , Fu Xiaokang , Yang Miaoqian , Sun Mengxi , Ma Liang , Lian Boying , Wu Hongmei , Li Yiran , Yu Shuxun , Wei Hengling , Wang Hantao
Published: February 2025

Upland cotton (Gossypium hirsutum) is a principal economic crop and a fundamental raw material for the textile industry. The quality of cotton fibres is significantly influenced by the synthesis of cell wall polysaccharides. This study focuses on GhIRX10, a beta‐1,4‐xylosyltransferase crucial for xylan backbone synthesis. Overexpression of GhIRX10 enhances xylan synthesis, which impacts fibre elongation and secondary cell wall thickening. GhMYB102, identified as a direct regulator of GhIRX10 expression, was confirmed through comprehensive validation. Overexpression of GhMYB102 resulted in a similar phenotype as OE‐GhIRX10: increased cell wall thickness and reduced fibre length. Overexpression of GhMYB102 upregulated the expression of key cell wall synthesis‐related genes, including GhCESA4/7/8, GhIRXs, GhCESAs, GhGUXs, GhTBLs, GhXTHs, and GhXXTs. Consequently, the cellulose and hemicellulose contents in OE‐GhMYB102 lines were significantly increased. GhMYB102 was also validated as a target gene regulated by GhFSN1 and GhMYB7, with the ability to reciprocally regulate GhFSN1 expression. In summary, we propose a regulatory model where GhMYB102 promotes the expression of GhIRX10 and other cell wall‐related genes, thereby affecting fibre quality. This study elucidates the regulatory network of secondary cell wall synthesis in cotton and provides potential targets for improving fibre quality through molecular breeding.
Mites on Caatinga remnants vegetation in Northeast Brazil, with description of a new species of Phytoseiidae (Acari: Mesostigmata)
Authors: Rodrigues J.K. , Almeida-Neto M. , Demite P.R. , Silva L.R.A. , Araújo I.F. , Castro E.B. , Gondim Jr M.G.C. , Lofego A.C.
Published: February 2025

The Caatinga biome is unique to Brazil, covering approximately 13% of the country's territory with an estimated area of around 800,000 km2, encompassing 70% of the Northeast Region of Brazil. Studies on the diversity of mite species in natural areas are still in the early stages yet are essential because understanding the diversity of these organisms in unexplored environments enables the development of strategies for managing harmful species. Therefore, this study aims to survey Caatinga areas to contribute to the knowledge of the mite diversity occurring in this biome. The study was conducted in three remaining areas of Caatinga, at the following locations: i) Aiuaba Ecological Station, Ceará state; ii) Fazenda das Almas Private Natural Heritage Reserve, Paraíba state; iii) Seridó Ecological Station, Rio Grande do Norte state. More than 5,200 mite specimens were collected, representing 32 species from 10 families. The predatory mite family Phytoseiidae was the most diverse, with 14 species recorded. Among the phytophagous mites, three families were particularly represented: Eriophyidae, Tenuipalpidae, and Tetranychidae. However, no phytophagous species were found in high abundance. Despite the challenging climatic conditions, the Caatinga biome harbors a considerable diversity of plant-dwelling mites. In this study, a new species of Phytoseiidae, Amblyseius suassunai sp. nov., is described and illustrated.
The negativity bias is encoded in language
Authors: Kilpatrick Alexander
Published: February 2025

This study investigates the relationship between emotional valence, phonemic bigram surprisal, and memory in American English. It reveals that negative words carry more Shannon's information—a measure of the transitional probability of phonemes within a word — than neutral or positive words and that increased information is associated with better memory performance. Specifically, words with negative valence and high surprisal were associated with increased hit rates and d′ scores in an existing memory recognition experiment. These findings offer insights into the interaction between language structure and cognitive processing, with broader implications for memory and the evolution of communication.
Coaches’ Observations of Eating Disorder Symptoms Among Athletes: Initial Validation of the Norwegian Translated Athlete Eating Psychopathology Observation Questionnaire
Authors: Diaz de Leon Irina , Sandgren Sebastian S.
Published: February 2025

Eating disorders (EDs) pose serious health and performance risks and are especially prevalent among athletes. Coaches, who are crucial in supporting athletes’ well-being, often lack knowledge and awareness of ED symptoms. We aimed to translate the Athlete Eating Psychopathology Observation Questionnaire to Norwegian to explore which symptoms of eating psychopathology coaches in Norway observe among their athletes and how the observation of these symptoms might differ. A forward–backward translation was conducted, and a total of 311 coaches (52% male) were included. Factor Analysis revealed a 16-item, four-factor solution (Negative Affect, Dieting Practices, Fear of Eating, Compulsive Exercise). Participants most frequently reported observing symptoms related to Negative Affect and coaches with more coaching experience were more likely to observe symptoms of eating psychopathology. On average (Athlete Eating Psychopathology Observation Questionnaire global score), more coaches reported not observing symptoms (76%) compared with those who were sure they had observed symptoms among their athletes (24%). We encourage future researchers to use and evaluate the Athlete Eating Psychopathology Observation Questionnaire further. It is important for coaching programs and coaches’ professional development to prioritize education on EDs and disordered eating. Consequently, coaches may improve their knowledge, awareness, and ability to detect symptoms of EDs in athletes.
Particle-associated N
2
fixation by heterotrophic bacteria in the global ocean
Authors: Chakraborty Subhendu , Andersen Ken H. , Merico Agostino , Riemann Lasse
Published: February 2025

N
2
-fixing microorganisms (diazotrophs) sustain life on our planet by providing biologically available nitrogen to plants. In the oceans, cyanobacterial diazotrophs, mostly prevalent in warm tropical and subtropical waters, were traditionally considered the sole contributors to marine N
2
fixation. Recently, an almost ubiquitous distribution of N
2
-fixing heterotrophic bacteria has been discovered in the pelagic ocean. However, the mechanisms enabling heterotrophic diazotrophs to thrive in cold high-latitude waters and their contribution to the global nitrogen budget are unknown. Using a data-driven cell-based metabolic model, we show that heterotrophic bacteria inside sinking particles can fix N
2
over a wide range of temperatures, explaining their ubiquitous presence in the oceans. We estimate that heterotrophic diazotrophs account for about 10% of global marine N
2
fixation, with the highest contribution in oxygen minimum zones. These findings call for a reassessment of the N
2
fixation patterns and the biogeochemical cycling of nitrogen in the global ocean.
Restoration of tactile sensation in bionic hands
Authors: Matsiko Amos
Published: February 2025

Somatosensory cortex stimulation enabled restoration of tactile feedback, permitting bionic hand users to discern objects.
Gluconolactone restores immune regulation and alleviates skin inflammation in lupus-prone mice and in patients with cutaneous lupus
Authors: Li Wei , Kolios Antonios G. A. , Pan Wenliang , Burbano Catalina , Karino Kohei , Vichos Theodoros , Humbel Morgane , Kyttaris Vasileios C. , Tsokos Maria G. , Tsokos George C.
Published: February 2025

Systemic lupus erythematosus (SLE) is characterized by dysfunctional regulatory T cells (T
regs
). We previously showed that protein phosphatase 2A (PP2A) plays a critical role in maintaining the suppressive function of T
regs
. Here, we analyzed phosphoproteomics and metabolomics data from PP2A–wild type and PP2A-deficient T
regs
and demonstrated that PP2A regulates T
reg
function through the pentose phosphate pathway (PPP). Furthermore, we proved that the PPP metabolite gluconolactone (GDL) enhances in vitro induced (i)T
reg
differentiation and function by promoting forkhead box protein 3 and phosphorylated signal transducer and activator of transcription 5 expression and inhibits T helper 17 (T
H
17) differentiation in murine cells. In short-term imiquimod-induced autoimmunity in mice, treatment with GDL alleviates inflammation by inhibiting T
H
17 cells. GDL promotes T
regs
function and alleviates skin lesions in MRL.
lpr
lupus-prone mice in vivo. It also promotes T
regs
differentiation and function in ex vivo experiments using cells from patients with SLE. Last, in patients suffering from cutaneous lupus erythematosus, topical application of a GDL-containing cream controlled skin inflammation and improved the clinical and histologic appearance of the skin lesions within 2 weeks. Together, we have identified GDL as a PPP metabolite and showed mechanistically that it restores immune regulation in vitro and in vivo by inducing T
reg
suppressive function and inhibiting T
H
17 cells. GDL should be considered as a treatment approach for inflammatory and autoimmune diseases.
Microbiota does not influence tumor development in two models of heritable cancer
Authors: Spring Jessica , Gurbuxani Sandeep , Golovkina Tatyana
Published: February 2025

Microbial impact on tumorigenesis of heritable cancers proximal to the gut is well-documented. Whether the microbiota influences cancers arising from inborn mutations at sites distal to the gut is undetermined. Using two models of heritable cancer,
Trp53
-deficient mice and Wnt1-transgenic mice, and a gnotobiotic approach, we found the microbiota to be inconsequential for tumor development. This work furthers our understanding of the degree of the microbial impact on tumor development.

IMPORTANCE

The influence of the microbiome on the development of cancer is well-documented with many if not all published studies reporting either a positive or a negative impact. None of the published studies, however, presented data on the influence of the microbiome on the development of heritable cancer. We find that the microbiota has no influence on cancer development in two models of spontaneous cancers driven by germline
Trp53
deficiency and constitutive Wnt1 signaling.
Validation of rectal swabbing for total and aerobic gut microbiota study
Authors: Marin Julie , Bertoye Paul Albin , Birgy Andre , Dziri Samira , Lescat Mathilde
Published: February 2025

In microbiota research, whole stool sampling is the conventional approach but can be problematic or infeasible for certain patients. This study aims to validate the use of rectal swabbing as an alternative method for microbiota analysis and determine optimal storage conditions suitable for various clinical settings, including intensive care units. We evaluated different sampling techniques and storage temperatures. Our findings indicated that rectal swabs yield microbiota diversity comparable to whole stool samples. Notably, storage conditions significantly impacted microbiota profiles, with increased
E. coli
and
Enterococcus sp
. quantifications observed at room temperature (RT). Consequently, we recommend immediate refrigeration of rectal swabs to reliably assess aerobic and total microbiota, particularly for patients requiring urgent care, such as antibiotic treatment.

IMPORTANCE

We developed a pragmatic approach to study total and aerobic gut microbiota, applicable in numerous clinical units, such as intensive care or emergency units, where whole stool sampling is often impractical. This approach employs ESwab devices, which are already commonly used in hospitals.
Barrow entropies in black hole thermodynamics
Authors: Capozziello Salvatore , Shokri Mehdi
Published: February 2025

We study the thermodinamic features of static, spherically-symmetric Schwarzschild black holes adopting different types of Barrow entropy. Specifically, in addition to the standard Barrow entropy, we consider a logarithmic-corrected type of this entropy by taking into account some loop quantum gravity effects. Moreover, we investigate the black hole thermodynamics from the viewpoint of Barrow entropy in presence of non-extensivity effects coming from the Tsallis statistics. Finally, we compare the results obtained for different Barrow-based entropies.
Short-Term Prediction Model of Output Power of Photovoltaic Power Generation System Based on Improved LSTM Neural Network and Traditional Regression Algorithm
Authors: Jiang Changming , Tang Yunpeng , Hao Zhen , Liu Jian , Liu Guangwei , Wang Xingmin
Published: February 2025

To address the impact of photovoltaics on the power system, a short-term prediction model of the output power of a photovoltaic power generation system based on an LSTM neural network and a traditional regression algorithm is proposed. It can be directly predicted using the historical output power value and past and predicted daily weather information. We analyze various output power factors and screen out suitable parameters as the input data. Given the defects of the traditional BP neural network, it will lead to the local minimum point and slow convergence speed, the use of increasing the momentum term and variable learning. It is improved by the method of combining rates. Finally, we verify the effectiveness of the proposed model by predictive analysis.
Staggered Boards, Innovation, and Firm Life Cycle
Authors: Kakhkharov Jakhongir , Milazzo Isabella , Osman Diaeldin
Published: February 2025

We explore the moderating effect of firm life cycle on the relation between staggered boards (classified boards) and innovation. To examine this relationship, a panel data fixed effects model is used to account for unobserved time-invariant heterogeneity. Results indicate the presence of a staggered board in the introduction stage of firm life cycle hinders innovation leading to a decreased number of patents. The outcomes of this research enable the decision-makers of companies and regulators to make more informed decisions regarding the varying corporate governance mechanisms that may be beneficial to their set of circumstances and inform investors of the nuanced consequences of staggered boards.
MSR: A Personalized Movie Recommendation Model Based on Gate Mechanism and Attention Network
Authors: Liu Lei , Zhu Jie , Mi Jia , Li Jing , Cao Xinyu , Wang Haitao
Published: February 2025

Personalized recommendation systems play a crucial role in alleviating information overload and satisfying users’ specific preferences. To address the challenges of inadequate user historical data extraction and the cold start problem inherent in traditional movie recommendation systems, we present a novel personalized movie recommendation model known as “movie recommendation with starring roles and ratings” (MSR). By incorporating a multi-head attention mechanism, the model captures intricate relationships among diverse data fields within users’ viewing records and facilitates the extraction of user features through the basic information-rating joint attention network (BRJA). The gate mechanism efficiently integrates fundamental movie information and average score into the movie representation vector, thereby generating candidate movie features. MSR can effectively provide recommendations even when confronted with limited user information, effectively mitigating the cold start problem. Comparative experiments on the movie lens dataset and ablation experiments focusing on key modules demonstrate the effectiveness of MSR in improving movie recommendations.
Forward-Mode Automatic Differentiation of Compiled Programs
Authors: Aehle Max , Blühdorn Johannes , Sagebaum Max , Gauger Nicolas R.
Published: February 2025

Algorithmic differentiation (AD) is a set of techniques that provide partial derivatives of computer-implemented functions. Such functions can be supplied to state-of-the-art AD tools via their
source code
, or via intermediate representations produced while compiling their source code.

We present the novel AD tool Derivgrind, which augments the
machine code
of compiled programs with forward-mode AD logic. Derivgrind leverages the Valgrind instrumentation framework for structured access to the machine code, and a shadow memory tool to store dot values. Access to the source code is required at most for the files in which input and output variables are defined.

Derivgrind’s versatility mainly comes at the price of reduced run-time performance. According to our extensive regression test suite, Derivgrind produces correct results on GCC- and Clang-compiled programs, including a Python interpreter, with a small number of exceptions. We provide a list of “bit-tricks” that Derivgrind does not handle correctly, some of which actually appear in highly optimized math libraries. As long as differentiating those is avoided, Derivgrind enables black-box forward-mode AD for an unprecedentedly wide range of cross-language software with little integration efforts.
Revisiting VerilogEval: A Year of Improvements in Large-Language Models for Hardware Code Generation
Authors: Pinckney Nathaniel , Batten Christopher , Liu Mingjie , Ren Haoxing , Khailany Brucek
Published: February 2025

The application of large-language models (LLMs) to digital hardware code generation is an emerging field, with most LLMs primarily trained on natural language and software code. Hardware code like Verilog constitutes a small portion of training data, and few hardware benchmarks exist. The open-source VerilogEval benchmark, released in November 2023, provided a consistent evaluation framework for LLMs on code completion tasks. Since then, both commercial and open models have seen significant development.

In this work, we evaluate new commercial and open models since VerilogEval’s original release—including GPT-4o, GPT-4 Turbo, Llama3.1 (8B/70B/405B), Llama3 70B, Mistral Large, DeepSeek Coder (33B and 6.7B), CodeGemma 7B, and RTL-Coder—against an improved VerilogEval benchmark suite. We find measurable improvements in state-of-the-art models: GPT-4o achieves a 63% pass rate on specification-to-RTL tasks. The recently released and open Llama3.1 405B achieves a 58% pass rate, almost matching GPT-4o, while the smaller domain-specific RTL-Coder 6.7B models achieve an impressive 34% pass rate.

Additionally, we enhance VerilogEval’s infrastructure by automatically classifying failures, introducing in-context learning support, and extending the tasks to specification-to-RTL translation. We find that prompt engineering remains crucial for achieving good pass rates and varies widely with model and task. A benchmark infrastructure that allows for prompt engineering and failure analysis is essential for continued model development and deployment.
Advancements in Agriculture 4.0 and the Needs for Introduction and Adoption in Ethiopia: A Review
Authors: Mihret Yabebal Chekole , Takele Mulu Marie , Mintesinot Smegnew Moges
Published: February 2025

To address the food security of Ethiopia’s fast‐growing population, transforming agriculture to Agriculture 4.0 is paramount by integrating emerging technologies such as remote sensing, big data, and artificial intelligence. This review explores its components, benefits, challenges, and opportunities in Ethiopia by employing deductive reasoning through a literature review. The findings indicated that Agriculture 4.0 could optimize resources, reduce production costs, provide real‐time information, and allow farmers to draw well‐informed judgments. It could contribute to sustainability and food security by increasing yield, productivity, and food quality, reducing waste, and enhancing product traceability. It also develops agri‐tech companies that create jobs, increasing the need for tech‐driven professions in agriculture and allowing smallholder farmers to compete in larger markets. Despite the advantages, in Ethiopia, the availability of scattered and small landholdings, limited farmers’ budgets, poor infrastructure, dependence on importation of technologies, increased tenure insecurity, skill shortage, and lack of training can discourage the implementation of Agriculture 4.0. However, the 2025 digital Ethiopia and climate‐smart agriculture initiative, the introduction of 5G networks and data centers, and tax exemption on agricultural machinery imports could open chances for adopting Agriculture 4.0 in the country. To successfully implement it in the country, the government and concerned bodies should work to establish microfinance and subsidies for farmers, increase market access and literacy rate, encourage collaboration, and invest in rural infrastructure. As a result, Ethiopia can improve food security, promote environmental sustainability, create more jobs, and build a resilient agriculture to support its fast‐growing population.
Assessing the Economic Impacts of Net Metering on Residential Solar Photovoltaic Adoption: A Palestinian Case Study
Authors: Omar Moien A.
Published: February 2025

This research evaluates impacts of net metering on residential photovoltaic (PV) adoption in Palestine, focusing on PV systems ranging from 2 to 5 kWp. The analysis considers key factors such as energy generation, self‐consumption, self‐sufficiency, and economic viability, with PV coverage meeting an annual demand of 6378 kWh. Under the current net‐metering scheme, 10% discounted of exported energy, and unused energy is forfeited at year end. The 2 kWp system generated 3405 kWh annually, achieving a self‐consumption rate of 63% and covering 35% of household energy needs. Conversely, the 5 kWp system produced 8514 kWh but exhibited a lower self‐consumption rate of 31% and a self‐sufficiency rate of 43%. In terms of economic performance, the 2 kWp system delivered the highest internal rate of return (IRR) at 23.60% and a discounted payback period (DPP) of 4.95 years. Meanwhile, the 3 kWp and 4 kWp systems demonstrated IRRs of 23.1% and 22.76%, with DPPs of 5.07 and 5.15 years, respectively. Although the 4 kWp system had a higher net present value of $5,626.8 compared to $2968.2 for the 2 kWp system, the latter remained more efficient with a higher IRR of 23.60%, vs. 22.76% for the 4 kWp system, suggesting that the 4 kWp system offers greater overall profit, but the 2 kWp system yields better returns on investment. Nevertheless, the 5 kWp system, despite generating the most energy, had the lowest IRR at 16.72% and the longest DPP of 7.20 years due to discounted and forfeited credits at year end. Therefore, the study recommends that households install PV systems closely aligned with their energy consumption to maximize self‐consumption.
Macromorphology, Microstructure, Mechanical Properties, and Elemental Composition of Enamel and Dentine in the Eurasian Otter Lutra lutra
Authors: AlShukri Yahya , Visser Ingrid N. , Wiig Øystein , Loch Carolina
Published: February 2025

Eurasian otters (Lutra lutra) are mammals found in waterways and coastal areas of Europe, parts of Asia, and northern Africa, where they inhabit aquatic environments with adequate food resources, primarily fish. This descriptive study aimed to investigate and describe the macromorphology, microstructure, mechanical properties, and elemental composition of teeth in two subadult Eurasian otters. A total of six teeth, comprised of two upper incisors, two canines, one premolar, and one molar tooth of two subadult Eurasian otters were analyzed. Teeth were measured, photographed, embedded in epoxy resin, sectioned, polished, and etched for scanning electron microscope (SEM) imaging, nanoindentation, and elemental composition analyses. The enamel of the Eurasian otter specimens analyzed was prismatic, ranging in thickness from 115 to 250 μm in incisors, 150–265 μm in canines, and 120–930 μm in postcanine teeth. The overall enamel microstructure was characterized by distinct transversely oriented undulating Hunter–Schreger bands, running from the enamel–dentine junction (EDJ) to the outer enamel surface, with bands of 5–8 prisms thick. The prisms were semicylindrical in shape with 4–6 μm diameter. Enamel tufts and lamellae were observed near the EDJ, which was straight with minimal scalloping. CaO and P2O5 were the main components in both enamel and dentine; other minor components such as Na2O, MgO, Cl, and SrO were also observed. The dental characteristics of Eurasian otters are similar to other carnivores and reflect their diet and phylogeny. Such comparative dental studies can contribute to our understanding of the biology, functional morphology of and evolution of otters and other closely related species.
Recent Advances in Automatic Modulation Classification Technology: Methods, Results, and Prospects
Authors: Zheng Qinghe , Tian Xinyu , Yu Lisu , Elhanashi Abdussalam , Saponara Sergio
Published: February 2025

As an essential technology for spectrum sensing and dynamic spectrum access, automatic modulation classification (AMC) is a critical step in intelligent wireless communication systems, aiming at automatically recognizing the modulation schemes of received signals. In practice, AMC is challenging due to the influence of communication environment and signal parameters, such as unknown channels, noise, symbol rate, signal length, and sampling frequency. In this survey, we investigated a series of typical AMC methods, including key technology, performance comparisons, advantages, challenges, and future key development directions. According to the methodology and processing flow, AMC methods are divided into three categories: likelihood‐based (Lb) methods, feature‐based (Fb) methods, and deep learning methods. The technical details of various types of methods are introduced and discussed, such as likelihood distributions, artificial features, classifiers, and network structures. Then, extensive experimental results of state‐of‐the‐art AMC methods on public or simulated datasets are compared and analyzed. Despite the achievements that have been made, there are still limitations of the individual methods, including generalization capability, reasoning efficiency, model complexity, and robustness. In the end, we summarized the severe challenges faced by AMC and key future research directions.
A Novel Nonlinear Output‐Only Damage Detection Method Based on the Prediction Error of PCA Euclidean Distances Under Environmental and Operational Variations
Authors: Huang Jiezhong , Yuan Sijie , Li Dongsheng , Jiang Tao
Published: February 2025

Vibration‐based damage detection relies on changes in structural dynamic features. However, environmental and operational variations (EOVs) can cause changes in dynamic features that mask those caused by damage. In addition, the EOV effects on dynamic features are often nonlinear, which limits the application of many linear damage detection methods. A novel nonlinear output‐only method is proposed to address this. This method leverages variational mode decomposition (VMD) as a preprocessing step to remove seasonal patterns and noise from the modal frequencies. The first modes of the decomposition results (IMF1 signals) are then used to calculate the Euclidean distance based on the residual obtained by the principal component analysis (PCA) method. To eliminate the nonlinear EOV effects and provide normalized damage features for reliable continuous dynamic monitoring, a Gaussian process regression (GPR) model is trained to learn the underlying calculation rule of the PCA Euclidean distance. Due to the linear nature of PCA, the nonlinear EOV effects are still retained in both the PCA Euclidean distance and the GPR–predicted value. Through a subtraction process, their common nonlinear environmental effects can be removed, and the resulting prediction error can serve as a normalized feature sensitive to structural damage. The proposed method is validated through a simulated 7‐DOF example and real data from the Z24 bridge, with several comparisons highlighting its effectiveness.
Targeting PRC2 Enhances the Cytotoxic Capacity of Anti-CD19 CAR-T Cells Against Hematological Malignancies
Authors: Carvalho Maria Leticia R. , Andrade Clara O. , Cabral-Piccin Mariela P. , Kinker Gabriela S. , Vitiello Glauco A. F. , Cambui Raylane A. G. , Abdo Luiza , Mannarino Eduardo , Elias Bruno D. S. , Araujo Emmanuel Vinicius O. , Chaves Alexandre S. , Pereira Pedro Henrique B. , Hajdu Karina , Rondinelli Amanda , Gusmao Arianne , Pierre Maria Luisa M. , Brasil-Costa Igor , Zanella Caroline P. , Lemos Marta Maria M. , Batista Marjorie V. , Filho Jayr S. , Arrowsmith Cheryl , de Lima Vladmir Cordeiro , Bonamino Martin , da Silva Medina Tiago
Published: February 2025

Chimeric antigen receptor (CAR) T cell therapy is increasingly being adopted as a clinical modality for patients with relapsed/refractory hematological malignancies. Despite the clinical efficacy of CAR-T cell therapy, a considerable fraction of patients still relapses during the first months following CAR-T cell infusion. The limited CAR-T cell efficiency is thought to relate to epigenetic mechanisms involved in T cell suppression and dysfunction. Here, screening of multiple epigenetic inhibitors revealed that targeting PRC2 consistently induced the development of granzyme B+ effector memory CD8+ T cells. Notably, PRC2 inhibition also promoted the long-term persistence of granzyme B+ effector memory 19BBζ CAR-T cells and sustainably enhanced their antitumor activity both in vitro and in vivo. Consistent with their long-lasting antitumor activity, PRC2-inhibited 19BBζ CAR-T cells did not exhibit signs of exhaustion over time. Furthermore, TCR restimulation along with PRC2 inhibition promoted the differentiation of patient-derived anti-CD19 CAR-T cells to a granzyme B+ effector memory phenotype with enhanced cytotoxic features that elicited potent antitumor responses. A gene signature derived from in-house PRC2-inhibited 19BBζ CAR-T cells was enriched in tisagenlecleucel (tisa-cel) BBζ CAR-T cell therapy responders with large B-cell lymphoma. Collectively, these results demonstrate that targeting PRC2 may be a promising approach to enhance a functional effector program in CAR-T cells to improve the efficacy in treating hematological malignancies.
Residential segregation and colorectal cancer screening in the United States, 2010-2018
Authors: Santiago-Rodriguez Eduardo J. , Shariff-Marco Salma , Bailey Zinzi D. , White Justin S. , Allen Isabel E. , Hiatt Robert A.
Published: February 2025

Background: Residential segregation limits the access to resources, primarily due to disinvestment. This study evaluated the association between residential segregation and colorectal cancer (CRC) screening in the US, and whether findings differed by race and ethnicity. Methods: Restricted National Health Interview Survey data (2010-2018) were used to ascertain CRC screening adherence per USPSTF recommendations. Residential segregation was operationalized using the Index of Concentration at the Extremes (ICE), based on income, race, and ethnicity information obtained from the 2014-2018 American Community Survey estimates for counties. Multivariable logistic regression models with robust variance estimators accounting for within-county correlation were used. Analyses were stratified by race and ethnicity, and weighted to represent the US population. Results: In this cross-sectional study (n=44,690), participants residing in less advantaged counties had lower CRC screening adherence than those residing in the most advantaged counties (Q1 vs Q5, OR [95% CI]: ICE income, 0.77 [0.70-0.86]; ICE race, 0.86 [0.77-0.96]; ICE race+income, 0.75 [0.67-0.84]. In race and ethnicity stratified analyses, we observed that overall findings were mostly driven by White people, and estimates were less precise with no clear gradients among racial and ethnic minoritized groups. Among Black participants, CRC screening did not vary across quintiles of economic segregation. Conclusions: Residential segregation was associated with CRC screening. Impact: Interventions aimed at improving CRC screening uptake in the US should address structural barriers present in areas with higher concentrations of low-income minoritized racial and ethnic groups, and how features of residential segregation might diferentially affect racial and ethnic groups.
Table S2 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

Supplementary Table 2 shows enriched gene sets upregulated in OVCAR3 cells treated with talazoparib.
Figure S3 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

Supplementary Figure 3 shows CXCL10 gene and protein expression levels in drug-treated cell lines.
A new, conspicuously coloured snapping shrimp from the north-western Indian Ocean (Malacostraca: Decapoda: Alpheidae: Alpheus)
Authors: Anker Arthur
Published: February 2025

A new, brightly coloured and morphologically distinctive species of the alpheid genus Alpheus Fabricius, 1798 is described based on a single female specimen collected in shallow waters of Masirah Island, Oman. Alpheus sarapis sp. nov. appears to be morphologically somewhat intermediate between the A. leviusculus Dana, 1852, A. edwardsii (Audouin, 1826) and A. paracrinitus Miers, 1881 species groups, although the presence of slight sinuses on the major chela palm suggests that it may be a derived member of either of the former two groups.
Sérgio Paulo Rouanet e a fundação da filosofia da psicanálise no Brasil
Authors: Simanke Richard Theisen
Published: February 2025

Os trabalhos de Rouanet participam como protagonistas no período de fundação da filosofia brasileira da psicanálise, embora sua contribuição, de forma alguma, tenha se encerrado aí. Seus trabalhos publicados nos anos 1980 foram pioneiros na abertura de vias de diálogo entre a psicanálise e diversas tradições filosóficas, como a Escola de Frankfurt ou o Iluminismo, e com a história da filosofia como um todo. O objetivo deste trabalho é fazer uma análise inicial da contribuição de Rouanet neste processo, identificando seus principais eixos temáticos e avaliando sua repercussão e influência.
Individuação e imaginação simbólica em C. G. Jung – Um diálogo possível com o neo-Iluminismo
Authors: Barreto Marco Heleno
Published: February 2025

A indisfarçável têmpera romântica da psicologia analítica forjada por C. G. Jung poderia, à primeira vista, torná-lo um pensador estranho a um evento que celebra o Iluminismo como valor. No entanto, uma consideração mais detida e livre de simplificações preconcebidas do pensamento de Jung (e do próprio Romantismo) pode descortinar perspectivas que podem e devem ser integradas em uma posição neo-iluminista crítica e consequente. Pretendo mostrar essa possibilidade examinando a concepção de individuação em Jung, compreendida segundo o ângulo da problemática universalidade-particularidade.
Análise da satisfação e uso da prótese em pessoas com amputação de membros inferiores protetizadas
Authors: Costa Wilker Santos , Secco Milena Zavatini , Bavaresco Ana Regina de Souza , Mauad Leonardo Dutra de Salvo , Fonseca Marisa de Cássia Registro
Published: February 2025

A satisfação protética é fundamental, pois interfere na adesão do paciente ao processo de reabilitação, auxilia a otimizar o uso da prótese e diminui a rejeição.
Análise do treinamento de marcha assistida em Lokomat em criança com paralisia cerebral
Authors: Silva Larissa Russo Veloso e , Marques Jaqueline Covatti , Siena Wilian Carlos , Souza Daniel Gottardo de , Barbosa Everton Horiquini
Published: February 2025

A paralisia cerebral descreve um grupo de desordens permanentes do desenvolvimento, do movimento e postura atribuídos a um distúrbio não progressivo que ocorre durante o desenvolvimento do cérebro fetal ou infantil, podendo contribuir para limitações no perfil de funcionalidade da pessoa. A desordem motora na paralisia cerebral pode ser acompanhada por distúrbios sensoriais, perceptivos, cognitivos, de comunicação e comportamental, por epilepsia e por problemas musculoesqueléticos secundários.
Aplicação de terapia robótica (C-Mill) para reabilitação de paciente com lesão de sistema nervoso central
Authors: Dalbeto Fabio Augusto Moraes Dias , Siena Wilian Carlos , Simas Desiree Garcia de , Bonatelli Deiseane , Souza Daniel Gottardo de
Published: February 2025

A tecnologia por meio da terapia robótica, atualmente, vem ocupando uma importante posição para a sociedade atual. Observa-se que esse tipo de abordagem favorece de maneira bastante significativa a complementação terapêutica frente a um processo de reabilitação. Isso justifica o aumento de investimento na área da saúde com a finalidade de criações de que contribuam para a assistência dos pacientes.  Assim, o que se percebe é que recentemente a utilização das terapias robóticas na reabilitação humana vem ocupando cada vez mais espaços dentro do tratamento, pois se mostra uma influência benéfica dentro desse processo, visto que notoriamente ela dinamiza e proporciona resultados positivos nas sessões de reabilitação. Além disso, os mecanismos da robótica proporcionam a execução de determinados exercícios de modo controlado, eficaz e confiável, sendo validado na literatura como fator essencial para a melhora da habilidade motora. Isso atrelado ao lado lúdico dos equipamentos que possibilitam maior interação aos pacientes e consequentemente um maior envolvimento e diversão, o que reflete diretamente na permanência e confiança no processo de reabilitação.
Capacidade funcional, conhecimento, força e espessura muscular de mulheres idosas com artrite reumatoide
Authors: Mineiro Lindomar , Silva Tamires Terezinha Gallo da , Paiva Eduardo dos Santos , Funke Andreas , Gomes Anna Raquel Silveira
Published: February 2025

Mulheres idosas com artrite reumatoide (AR) apresentam função musculoesquelética com declínio acentuado, mais comorbidades como osteoporose, osteoartrite; sarcopenia; aumento do risco de quedas, quedas recorrentes, fraturas, redução da função musculoesquelética, incapacidade física e mortalidade. Além de pior prognóstico, do que as mais jovens. Podendo apresentar redução da capacidade funcional, da força e massa muscular do quadríceps e maior risco de quedas. O conhecimento da doença para pacientes com AR tem sido um indicador efetivo para o autocuidado.
Caracterização clínica e epidemiológica dos pacientes com lesão medular traumática admitidos no Hospital SARAH - São Luís
Authors: Pereira Rafael de Mattos , Amorim Joyce Arcoverde Modesto
Published: February 2025

A lesão medular consiste na injúria às estruturas contidas no canal medular (medula, cone medular e cauda equina), podendo levar a disfunções motoras, sensitivas, autonômicas e psicoafetivas. Podem ocorrer perda do controle esfincteriano, disfunção sexual, paralisia dos membros, alteração do tônus muscular, da sensibilidade, alterações do sistema nervoso autônomo (sudorese, controle da temperatura corporal, vasoplegia). Causa grande repercussão física, psíquica e social.
Cuidados de Enfermagem frente ao diagnóstico de neuromielite óptica: revisão bibliográfica
Authors: Castro Victor Augusto de
Published: February 2025

A Neuromielite óptica(NMO) foi descrita a primeira vez em um relato de caso pelo o médico frânces Eugene Devic. A doença conhecida inicialmente devido a mielite subaguda com amaurose bilateral de evolução grave está incluída no grupo de Doenças Desmielinizantes Inflamatórias Idiopáticas, imunomediada e necrotizante do Sistema Nervoso Central. As condições clínicas ainda é desconhecida devido as manifestações neurológicas e alterações inflamatórias, suas características incluem acometimento do nervo óptico e da medula espinhal. A NMO é uma doença rara (1-4,4:100mil < 65:100mil) que acomete predominantemente o sexo feminino com manifestações aos 39 anos. Justifica-se o conhecimento e assistência de enfermagem sobre diagnóstico da Neuromielite Óptica para gerenciamento dos cuidados.
Desmame de marcapasso diafragmático em indivíduo com lesão medular C2 pós programa de reabilitação física intensiva e multimodal: relato de caso
Authors: Rodrigues Ana Cláudia , Nunes Thalyta Souza de Góes , Iocca Bruna , Souza Daniel Rubio de , Padula Natalia
Published: February 2025

Segundo Berlowitz et al. a lesão medular (LM) cervical associa-se a déficits respiratórios por interrupção da inervação da musculatura respiratória, principalmente o diafragma. Tal condição resulta em comprometimento da função pulmonar e insuficiência respiratória, necessitando de intervenções e dispositivos para assistência ventilatória.
Eficácia da reabilitação neurocognitiva na melhoria e manutenção das atividades de vida diária em pacientes com doença de Alzheimer: uma revisão sistemática da literatura
Authors: Junior Mafra Zacarias
Published: February 2025

Dados da OMS indicam que cerca de 50 milhões de pessoas têm demência globalmente, com projeção de atingir 82 milhões em 2030 e 152 milhões em 2050. A doença de Alzheimer representa 60-70% dos casos, caracterizada pela deterioração cognitiva e física relacionada a placas β-amiloide e emaranhados neurofibrilares. Embora incurável, existem tratamentos farmacológicos e não farmacológicos. A terapia não farmacológica, multidisciplinar, inclui a reabilitação neuropsicológica e cognitiva, visando melhorar habilidades e compensar declínios, considerando as preferências do paciente. Este estudo, analisa ensaios clínicos randomizados para avaliar a eficácia da reabilitação cognitiva em estágios leves a moderados de Alzheimer, buscando identificar técnicas e benefícios na qualidade de vida, além de possíveis alterações funcionais e/ou estruturais decorrentes.
Informações contidas nos vídeos sobre dor lombar no Youtube seguem as diretrizes clínicas de reabilitação?
Authors: Fonsati Leonardo Bonicontro , Marques Nise Ribeiro , Esteves Mateus dos Reis , Silva Breno Moreira da , Navega Marcelo Tavella
Published: February 2025

A dor lombar é indicada como a condição musculoesquelética que mais gera incapacidade e perda de produtividade em adultos no mundo. Devido a alta pluralidade de tipos e tratamentos de dor lombar, diretrizes de prática clínica são um ótimo meio do clínico se atualizar quanto ao poder e recomendação da literatura científica para aumentar sua eficácia e diminuir o risco de efeitos adversos ao longo da sua carreira.
Papel do Plasma rico em plaquetas no manejo da dor
Authors: Costa Junior Carlos Antonio da , Braun Wellington Luiz Fagundes
Published: February 2025

Plasma rico em plaquetas (PRP) é um concentrado autólogo de plaquetas derivado de sangue do próprio paciente (Carr et al.). Na resposta orgânica à lesão, dá-se início a um processo regenerativo como resposta ao dano tecidual, auxiliado principalmente por plaquetas (Chiavaras et al.).
Parâmetros espaço-temporais da marcha de um indivíduo com amputação transtibial bilateral: relato de caso
Authors: Montagnana Larissa Aparecida , Costa Wilker Santos , Secco Milena Zavatini , Bavaresco Ana Regina de Souza , Mauad Leonardo Dutra de Salvo , Fonseca Marisa de Cássia Registro
Published: February 2025

As amputações de membros inferiores geram alterações funcionais importantes no padrão da marcha com uso de prótese. Nas amputações bilaterais, o controle de duas próteses pode se tornar ainda mais desafiador, exigindo maior treino e tempo de adaptação.
Perfil clínico de crianças com comprometimento do desenvolvimento neuropsicomotor atendidas em um centro de reabilitação de referência no município de Santos
Authors: Boff Yasmin Ribeiro , Souza Rafaela Batista , Azevedo Guilherme Garrido Alvaro de , Matos Celso Vilella , Silva Elaine Cristina da
Published: February 2025

O desenvolvimento neuropsicomotor (DNPM) é um processo complexo e contínuo de mudanças que ocorrem durante o período da infância. Durante o DNPM, os fatores intrínsecos da criança como a herança genética e seus fatores biológicos interagem com os fatores extrínsecos, como o ambiente cultural, físico e social em que essa criança está inserida. O atraso do DNPM é a principal causa pela qual os pais e/ou cuidadores buscam pelos serviços de reabilitação infantil nos últimos anos.
Perfil de pessoas em uso de cadeiras de rodas motorizadas em centro de reabilitação
Authors: Fernandes Luísa Alves , Ribeiro Darlan Martins
Published: February 2025

A mobilidade é crucial para indivíduos com deficiência, ressaltando a importância da cadeira de rodas motorizada (CRM) como uma forma de tecnologia assistiva voltada para aqueles com mobilidade reduzida. Projetada para aprimorar a locomoção tanto em ambientes internos quanto externos, a CRM é essencial para indivíduos que, de acordo com o Estatuto da Pessoa com Deficiência, podem enfrentar dificuldades de movimentação devido a diversos motivos, temporários ou permanentes, que resultam em uma efetiva redução da mobilidade, flexibilidade, coordenação motora ou percepção.
Perfil dos pacientes amputados de membro inferior acompanhados no Ambulatório do Serviço de Reabilitação da ISCMSP
Authors: Sumita Cesar Takeshi , Nishizawa Lucas Eiti , Rocha Eduardo de Melo Carvalho , Kuga Fábio Seiji , Yokomizo Patricia Lumi
Published: February 2025

A amputação de membro, um procedimento cirúrgico antigo, permanece como uma medida invasiva, reservada como último recurso para melhorar a função do membro afetado e evitar complicações extremas. No Brasil, entre 2011 e 2016, o SUS realizou mais de 100.000 cirurgias de amputação, com 70% relacionadas ao diabetes, principalmente afetando membros inferiores. A doença vascular periférica continua sendo a principal causa, seguida por traumas, afetando predominantemente homens.
Reabilitação neurológica na atrofia de múltiplos sistemas: um relato de caso
Authors: Moraes Lucas Levy Alves de , Fonseca Marcos Matheus da Silva , Akamine Eduardo Hideyuki
Published: February 2025

A Atrofia de Múltiplos Sistemas (AMS) é um distúrbio neurodegenerativo progressivo que causa disautonomia, parkinsonismo e sintomas cerebelares, além de demência, sintomas depressivos e dor.
Relato de caso Charcot Marie Tooth – CMT 2Q com mutação no gene DHTKD1
Authors: Casagrande Amanda Victoria , Nicola Pablo Domingos Rodrigues , Rocco Fernanda
Published: February 2025

A doença de Charcot Marie Tooth (CMT) é uma polineuropatia hereditária sensitiva e motora, que acomete nervos periféricos. CMT2Q é um subtipo raro de doença autossômica dominante CMT tipo 2. Essa mutação foi descrita pela primeira vez na China em 2012, a seguir na Índia em 2020, México em 2021 e este caso é subsequente, décimo primeiro caso no mundo, e o primeiro relatado na população brasileira.
Tratamento conservador de osteomielite crônica utilizando ondas de choque: relato de caso
Authors: Lamas Raquel Cotta , Martinez Luisa Fernanda Gamarra , Mourão Ana Lúcia Muniz Teixeira , Mourão Natália Teixeira
Published: February 2025

A osteomielite é uma infecção óssea persistente que pode ocorrer de forma hematogênica ou por contiguidade de um foco de infecção com origem traumática, cirúrgica ou implantes. O caso em questão se associa a trauma contuso há mais de 30 anos com história de tratamentos cirúrgicos e antibioticoterapias prévias com sequela de ferida em região proximal da tíbia direita, associado posteriormente à terapia de onda de choque (extracorporeal shockwave therapy) com objetivo de diminuir o tempo de cicatrização, proporcionando melhor reepitelização do tecido e, por fim, menor taxa de complicações.