bluuebunny/crossref_metadata_2025 huggingface dataset:
An International Survey of Gross Anatomy Courses in Chiropractic Colleges
Authors: Ball Jennette J. , Petrocco-Napuli Kristina L. , Zumpano Michael P.
Published: November 2012

Purpose: The purpose of this study is to provide the first comprehensive description of gross anatomy course design in chiropractic colleges internationally and to provide baseline data for future investigation, future comparison with other health care professions, and identification of trends. Methods: A 72-question cross-sectional electronic survey was sent to the anatomy department chair at 36 chiropractic colleges internationally using Zoomerang, a web-based survey instrument. To augment the survey response data, public sources of data also were collected. Results: Forty-four percent of the electronic surveys were returned and information was gathered for 31 institutions from public sources. These results indicate (1) the most common degrees held by anatomy faculty were MS and PhD in anatomy, and DC degrees; (2) 75% of institutions utilized human cadavers and 75% presented laboratory anatomical demonstrations; (3) 62% used PowerPoint and 100% provided students with copies of lecture presentations; (4) 88% required attendance in laboratory and 50% in lecture; (5) 69% issued one grade for lecture and laboratory; (6) 100% of laboratory examinations were anatomical identification; and (7) 80% of written examinations were multiple-choice format. Conclusions: While individual variations existed, chiropractic institutions internationally have similar gross anatomy faculty, course design, delivery methods, and assessment methods.
Distance Matters: Spatial Contiguity Effects as Trade‐Off between Gaze Switches and Memory Load
Authors: Bauhoff Vera , Huff Markus , Schwan Stephan
Published: November 2012

The present study combined the approaches of multimedia learning and of comparative visual search (Hardiess, Gillner, & Mallot, 2008) in order to analyse the processing of spatially separated information. Participants were asked to compare two depictions of a mechanical pendulum clock to detect no, one, or two differences between them. The spatial distance between the two depictions was varied, and participants received either stimulus‐related information about the functionalities of pendulum clocks or stimulus‐unrelated information about the design of cuckoo clocks. The study demonstrates a trade‐off between gaze movement and working memory use. We observed fewer gaze shifts with increasing distance between the pictures, suggesting higher working memory use. The findings indicate that the distance between two pictures, domain knowledge and visual working memory span are important factors that determine memory load required for processing split information sources. Copyright © 2012 John Wiley & Sons, Ltd.
Remembered Utility of Unpleasant and Pleasant Learning Experiences: Is All Well that Ends Well?
Authors: Hoogerheide Vincent , Paas Fred
Published: November 2012

Retrospective evaluation of the pain or pleasure associated with past episodes (i.e. remembered utility) is mainly determined by how the episodes felt when they were at their peak, and when they ended (Kahneman, Fredrickson, Schreiber, & Redelmeier, 1993). Two experiments were conducted to investigate whether this memory bias known as the peak‐end rule also affects the remembered utility of learning episodes and shapes study behaviour. Both the first experiment, which focused on unpleasant learning experiences imposing a very high cognitive load, and the second experiment, which focused on pleasant learning experiences imposing a low cognitive load, presented primary school children with a short study list and an extended study list with English–Dutch word pairs. Results showed that study experiences that ended on an experienced peak affect were evaluated as easier to learn and easier to cope with. These measures of remembered utility shaped children's immediate and delayed study behaviour. In addition, the pattern of affect induced by the word pairs that were added to the extended study list in both experiments suggests that the experience with new learning tasks is relative to the affect induced by the original learning task. The findings are congruent with the peak‐end rule and support the position that the design of learning environments could be improved by taking remembered utility into account. Copyright © 2012 John Wiley & Sons, Ltd.
Expedient Synthesis of Functionalized Triarylmethanols through Tandem Formation of Geminal CC and CO Bonds
Authors: Tian Yu , Sui Yi , Gu Yonghong , Tian Shi‐Kai
Published: November 2012

The rearrangement/oxidation of N,N‐disubstituted anilines and the formal dehydrogenative cross‐coupling of diarylmethanols with aniline derivatives have been developed for the preparation of symmetric and unsymmetric functionalized triarylmethanols. Both reactions proceed smoothly in trifluoroacetic acid in the presence of an inexpensive oxidant (manganese dioxide or potassium persulfate) and a catalytic amount of palladium diacetate to give a range of functionalized triarylmethanols in moderate to good yields and with extremely high regioselectivity. The two unprecedented reactions involve tandem formation of geminal CC and CO bonds, and they are synthetically useful, atom‐efficient, and operationally simple.
An Indium(III)‐Catalyzed Synthesis of 4,4‐Dichloro‐1‐aryl‐N‐alkyl‐1‐yn‐3‐amines via an Intermolecular C(sp2)C(sp) Bond Formation
Authors: Malakar Chandi C. , Maes Bert U. W. , Tehrani Kourosch Abbaspour
Published: November 2012

This paper demonstrates an indium(III) triflate‐catalyzed reaction of electron‐deficient α,α‐dichloroaldimines with terminal alkynes leading to a rapid and selective access to highly functionalized propargylic amines in good to excellent yields. The dichloromethylene moiety of the aldimine acts as an activating group to accomplish this transformation under very mild conditions.
Improving Competitiveness of Small‐ and Medium‐Sized Enterprises (SMEs) in Agriproduct Export Business Through ANP: The Turkey Case
Authors: Ada Erhan , Kazancoglu Yigit , Sagnak Muhittin
Published: November 2012

Agricultural production has considerable potential in Turkey. Different regions of the country are able to supply a variety of agricultural products due to the wide‐range of climate conditions and high land quality. Also, the majority of the water resources in the region are located within the country. Hence, with the implementation of the effective agricultural policies, agricultural products can be significantly increased in terms of quality and quantity. In this context, this study investigates findings from an explanatory study of dried fruit production and exports to improve SMEs’ competitiveness in the agriproduct export business. Turkey reported a trade deficit equivalent to USD 7533 million in November of 2011, and this shortfall is becoming more threatening day by day. Because Turkey has a comparative advantage in the dried food industry, it would be valuable to conduct a study to present a management decision tool to determine which factors are more important and to identify the weights that are most significant for dried fruit exporters. The analytical network process (ANP) method was selected to solve the problem because it has been successfully used to evaluate the factors when interdependency exists in between the decision criteria. The contributions of the study could be extended to other sectors and problem areas of business management because the approach, model, and methodology can be easily adopted by practitioners.
Asymmetrische Ionenpaarkatalyse
Authors: Brak Katrien , Jacobsen Eric N.
Published: November 2012

Geladene Intermediate und Reagentien sind in organischen Transformationen ubiquitär. Die Wechselwirkungen dieser ionischen Spezies mit chiralen neutralen, anionischen oder kationischen kleinen Molekülen haben sich zu einer leistungsfähigen Strategie in der katalytischen enantioselektiven Synthese entwickelt. Dieser Aufsatz beschreibt die Entwicklungen in dem aufstrebenden Gebiet der asymmetrischen Ionenpaarkatalyse mit dem Schwerpunkt auf strukturellen und mechanistischen Eigenschaften, die zu der hohen asymmetrischen Induktion dieser Reaktionen beitragen.
Rapid understanding of scientific paper collections: Integrating statistics, text analytics, and visualization
Authors: Dunne Cody , Shneiderman Ben , Gove Robert , Klavans Judith , Dorr Bonnie
Published: November 2012

Keeping up with rapidly growing research fields, especially when there are multiple interdisciplinary sources, requires substantial effort for researchers, program managers, or venture capital investors. Current theories and tools are directed at finding a paper or website, not gaining an understanding of the key papers, authors, controversies, and hypotheses. This report presents an effort to integrate statistics, text analytics, and visualization in a multiple coordinated window environment that supports exploration. Our prototype system, Action Science Explorer (ASE), provides an environment for demonstrating principles of coordination and conducting iterative usability tests of them with interested and knowledgeable users. We developed an understanding of the value of reference management, statistics, citation text extraction, natural language summarization for single and multiple documents, filters to interactively select key papers, and network visualization to see citation patterns and identify clusters. A three‐phase usability study guided our revisions to ASE and led us to improve the testing methods.
Synthesis and Thermal Decomposition Behaviors of Magnesium Borohydride Ammoniates with Controllable Composition as Hydrogen Storage Materials
Authors: Yang Yanjing , Liu Yongfeng , Li You , Gao Mingxia , Pan Hongge
Published: November 2012

An ammonia‐redistribution strategy for synthesizing metal borohydride ammoniates with controllable coordination number of NH3 was proposed, and a series of magnesium borohydride ammoniates were easily synthesized by a mechanochemical reaction between Mg(BH4)2 and its hexaammoniate. A strong dependence of the dehydrogenation temperature and purity of the released hydrogen upon heating on the coordination number of NH3 was elaborated for Mg(BH4)2⋅x NH3 owing to the change in the molar ratio of Hδ+ and Hδ−, the charge distribution on Hδ+ and Hδ−, and the strength of the coordinate bond N:→Mg2+. The monoammoniate of magnesium borohydride (Mg(BH4)2⋅NH3) was obtained for the first time. It can release 6.5 % pure hydrogen within 50 minutes at 180 °C.
Modulatory effect of methanolic extract of Vernonia amygdalina (MEVA) on tert‐butyl hydroperoxide–induced erythrocyte haemolysis
Authors: Adesanoye Omolola A. , Molehin Olorunfemi R. , Delima Adetutu A. , Adefegha Adeniyi S. , Farombi Ebenezer O.
Published: November 2012

Reactive oxygen species (ROS) have been implicated in the aetiology of several pathological and degenerative diseases. The protective effect of natural products possessing antioxidant properties has played a crucial role in ameliorating these deleterious effects. This study investigated the chemoprotective properties of the methanolic extract of Vernonia amygdalina (MEVA) in an experimental model of tert‐butyl hydroperoxide (t‐BHP)–induced human erythrocyte lysis in vitro.

Haemolysis was induced by incubating erythrocytes with t‐BHP (2 and 3 mM) in vitro. Samples of erythrocyte suspensions were removed at different intervals over a 6‐h period, and the degree of haemolysis was measured. The anti‐haemolytic effect of MEVA at 25–150 µg ml–1 concentrations on the samples were assessed and compared with Triton X‐100.

Administration of t‐BHP at 2‐ and 3‐mM concentrations significantly (p < 0.05) induced erythrocyte lysis by 37.5% and 31.4%, respectively. The addition of MEVA, however, reduced t‐BHP–induced erythrocyte lysis significantly (p < 0.05) by 39.3%, 48.4%, 67.3% and 73.4% at 25, 50, 100 and 150 µg ml–1 concentrations, respectively. MEVA likewise protected against t‐BHP–induced lipid peroxidation significantly (p < 0.05) at 100 and 150 µg ml–1 by the fourth hour and non‐significantly (p > 0.05) at all concentrations by the sixth hour. The reduced glutathione level was, however, increased with the administration of t‐BHP, while a delayed addition of MEVA had no protective effect on the t‐BHP–induced cell lysis.

These findings therefore suggest that MEVA may have protective antioxidant properties, making it suitable for incorporation into food and drug products. Copyright © 2012 John Wiley & Sons, Ltd.
Sequence‐Dependent Structural Dynamics of Primate Adenosine‐to‐Inosine Editing Substrates
Authors: Dahabieh Michael Samir , Samanta Dhrubajyoti , Brodovitch Jean‐Claude , Frech Christian , O'Neill Melanie A. , Pinto B. Mario
Published: November 2012

Humans have the highest level of adenosine‐to‐inosine (A‐to‐I) editing amongst primates, yet the reasons for this difference remain unclear. Sequence analysis of the Alu Sg elements (A‐to‐I RNA substrates) corresponding to the Nup50 gene in human, chimp, and rhesus reveals subtle sequence variations surrounding the edit sites. We have developed three constructs that represent human (HuAp5), chimp (ChAp5), and rhesus (RhAp5) Nup50 Alu Sg A‐to‐I editing substrates. Here, 2‐aminopurine (2‐Ap) was substituted for edited adenosine (A5) so as to monitor the fluorescence intensity with respect to temperature. UV and steady‐state fluorescence (SSF) TM plots indicate that local and global unfolding are coincident, with the human construct displaying a TM of approximately 70 °C, compared to 60 °C for chimp and 54 °C for rhesus. However, time‐resolved fluorescence (TRF) resolves three different fluorescence lifetimes that we assign to folded, intermediate(s), and unfolded states. The TRF data fit well to a two‐intermediate model, whereby both intermediates (M, J) are in equilibrium with each other, and the folded/unfolded states. Our model suggests that, at 37 °C, human state J and the folded state will be the most heavily populated in comparison to the other primate constructs. In order for adenosine deaminase acting on RNA (ADAR) to efficiently dock, a stable duplex must be present that corresponds to the human construct, globally. Next, the enzyme must “flip out” the base of interest to facilitate the A‐to‐I conversion; a nucleotide in an intermediate‐like position would enhance this conformational change. Our experiments demonstrate that subtle variations in RNA sequence might contribute to the high A‐to‐I editing levels found in humans.
α‐Complementation in an Artificial Genome Replication System in Liposomes
Authors: Nishiyama Kotaro , Ichihashi Norikazu , Matsuura Tomoaki , Kazuta Yasuaki , Yomo Tetsuya
Published: November 2012

Genome size is considered one of the limiting factors for the replication of primitive life forms. However, the relationship between genome size and replication efficiency has not been tested experimentally. In this study, we examined the effect of genome size on genome replication by using an artificial cell model: a self‐replicating RNA genome encapsulated in a liposome. For the reduced genome size we used α‐complementation of the lacZ gene. We first characterized α‐complementation in the purified translation system and then applied α‐complementation to the genome replication system. The reduction in the genome size together with the addition of ω‐fragment increased the replication efficiency approximately eightfold. This result provides experimental evidence that genome size can be a limiting factor for primitive self‐replication systems; it also implies that this artificial cell model could be a useful experimental model to identify possible mechanisms of genome enlargement.
Melody valve implantation in the pulmonary and tricuspid position
Authors: Petit Christopher J. , Justino Henri , Ing Frank F.
Published: November 2012

Percutaneous implantation of valved stents is now routinely performed to treat pulmonary valve regurgitation and stenosis. In addition, there are isolated reports of implantation of valved stents in the tricuspid position to treat prosthetic tricuspid stenosis or regurgitation when a prosthetic valve ring exists. We present a case in which a patient with combined severe tricuspid valve and pulmonary valve disease was successfully treated with sequential implantation of percutaneous valved stents in a single procedure. The procedure was straightforward, of short duration, and dramatically improved the patient's functional status. © 2012 Wiley Periodicals, Inc.
Inferior epigastric artery as a landmark for transfemoral TAVI. Optimizing vascular access?
Authors: Vavuranakis Manolis , Kalogeras Konstantinos , Vrachatis Dimitrios , Kariori Maria , Voudris Vasilios , Aznaouridis Konstantinos , Moldovan Carmen , Vaina Sophia , Lazaros Georgios , Masoura Konstantina , Thomopoulou Sophia , Stefanadis Christodoulos
Published: November 2012

Objectives

This study sought to investigate whether the site of common femoral artery (CFA) cannulation in regard to the inferior epigastric artery (IEA) is associated with the incidence of vascular complications in patients undergoing transfemoral aortic valve implantation (TAVI).

Background

Vascular access complications are a main issue during TAVI and have been associated with significant increase of morbidity and mortality. The need for establishment of reliable predictors for these serious events remains important.

Methods

A total of 90 patients, who had undergone TAVI, were retrospectively studied. Vascular complications were defined as major and minor according to the Valve Academic Research Consortium (VARC) criteria. Patients were divided into high cannulation site (CS) group and low CS group depending on the common femoral artery puncture site position, in regards to the most inferior border of the IEA.

Results

Vascular complications were significantly more frequent in the high CS group versus the low CS group (32.3% vs. 11.9%, P = 0.039). High cannulation remained an independent predictor of vascular complications after adjustment for known risk factors (OR: 4.827, CI: 1.441–16.168; P = 0.011).

Conclusions

In patients undergoing transfemoral TAVI, arterial puncture above the most inferior border of the IEA is associated with vascular complications. © 2013 Wiley Periodicals, Inc.
A “no‐option” left main PCI registry: Outcomes and predictors of in hospital mortality—utility of the logistic EuroSCORE
Authors: Elmayergi Nader , Nguyen Thang , Hiebert Brett , Philipp Roger K. , Jassal Davinder S. , Tam James W. , Hussain Farrukh
Published: November 2012

Background

Although high‐risk left main PCI populations have been previously described, there is little data describing outcomes and the role of the logistic EuroSCORE in surgical turndown cohorts or patients in extremis due to acute infarction or cardiogenic shock from left main ischemia.

Methods

Consecutive patients with unprotected LM PCI who were surgical turndowns or in extremis were included in this retrospective cohort from 2004 to 2009 at two tertiary centers. Predictors of in‐hospital mortality were identified utilizing routine and stepwise logistic regression.

Results

There were a total of 56 patients with mean age of 69 (±13). There were 23 (41%) patients with cardiogenic shock. The mean logistic EuroSCORE was 23.5% ± 21%. In‐hospital death occurred in 12 (21%) patients, largely restricted to the shock subgroup (11/12). Univariate predictors of mortality included peak CK levels (P = 0.01), transfusion (P = 0.01), cardiogenic shock (P < 0.002), male gender (P = 0.027), and logistic EuroSCORE (P = 0.01). Stepwise logistic regression yielded logistic EuroSCORE (P = 0.04, OR: 1.25 (95% CI: 1.01–1.56) for every 5% increase) and peak CK level (P = 0.001, OR: 1.23 (95% CI: 1.09–1.40) for every 500 unit increase) as independent predictors of in‐hospital mortality. The AUC ROC for logistic EuroSCORE was 0.73; and for logistic EuroSCORE plus peak CK level was 0.89.

Conclusion

PCI appears to be a reasonable option in the high risk “no option” LM population, with the logistic EuroSCORE and peak CK levels being independent predictors of in‐hospital mortality. Specifically, the logistic EuroSCORE and peak CK level combined discriminate in‐hospital mortality with a high degree of certainty. © 2013 Wiley Periodicals, Inc.
Palladium‐Based Nanocatalyst for One‐Pot Synthesis of Polysubstituted Quinolines
Authors: Chen Benjamin Wei Jie , Chng Leng Leng , Yang Jun , Wei Yifeng , Yang Jinhua , Ying Jackie Y.
Published: November 2012

The synthesis of quinolines has been achieved through a one‐pot, two‐step tandem reaction catalyzed with AgPd alloy nanoparticles supported on carbon. AgPd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α‐alkylated ketones under an Ar flow. These are reacted with 2‐aminobenzyl alcohols in a modified Friedländer synthesis to give polysubstituted quinolines in moderate to good yields.
Template‐Free Synthesis of Hierarchical Vanadium‐Glycolate Hollow Microspheres and Their Conversion to V2O5 with Improved Lithium Storage Capability
Authors: Pan Anqiang , Zhu Ting , Wu Hao Bin , Lou Xiong Wen (David)
Published: November 2012

Nanosheet‐assembled hierarchical V2O5 hollow microspheres are successfully obtained from V‐glycolate precursor hollow microspheres, which in turn are synthesized by a simple template‐free solvothermal method. The structural evolution of the V‐glycolate hollow microspheres has been studied and explained by the inside‐out Ostwald‐ripening mechanism. The surface morphologies of the hollow microspheres can be controlled by varying the mixture solution and the solvothermal reaction time. After calcination in air, hierarchical V2O5 hollow microspheres with a high surface area of 70 m2 g−1 can be obtained and the structure is well preserved. When evaluated as cathode materials for lithium‐ion batteries, the as‐prepared hierarchical V2O5 hollow spheres deliver a specific discharge capacity of 144 mA h g−1 at a current density of 100 mA g−1, which is very close to the theoretical capacity (147 mA h g−1) for one Li+ insertion per V2O5. In addition, excellent rate capability and cycling stability are observed, suggesting their promising use in lithium‐ion batteries.
ChemInform Abstract: Structure, Optical Properties, and Magnetism of the Full Zn1‐xCuxWO4 (0 ≤ x ≤ 1) Composition Range.
Authors: Yourey Joseph E. , Kurtz Joshua B. , Bartlett Bart M.
Published: November 2012

The title compounds are prepared by solid state reaction of stoichiometric mixtures of ZnO, CuO, and WO3 (alumina crucible, 850 °C, 36 h) and by a Pechini‐type citric acid sol—gel method.
ChemInform Abstract: The Synthesis and Crystal Structure of NpSe3.
Authors: Bellott Brian J. , Haire Richard G. , Ibers James A.
Published: November 2012

The title compound is synthesized in high yield by reaction of the elements in a Sb2Se3 flux (sealed silica tube, 1223 K, 48 h).
ChemInform Abstract: Synthesis and Crystal Structure of the Cesium Silver Permanganate Cs3Ag[MnO4]4.
Authors: Bauchert Joerg M. , Henning Harald , Schleid Thomas
Published: November 2012

The new title compound is obtained from aqueous solutions containing Cs2SO4, Ag2SO4, and Ba(MnO4)2 in different ratios.
ChemInform Abstract: Switchable Stereoselectivity: The Effects of Substituents on the D2‐Symmetric Biphenyl Backbone of Phosphoramidites in Copper‐Catalyzed Asymmetric Conjugate Addition Reactions with Triethylaluminum.
Authors: Yu Han , Xie Fang , Ma Zhenni , Liu Yangang , Zhang Wanbin
Published: November 2012

Ligand CPH and its trans‐isomer (P atom configuration), lacking substituents at the meta‐positions of the biphenyl give the (S)‐configurated addition product (IIIa), whereas ligand TPH, its cis‐isomer, and two other trans‐ligands, containing substituents at these positions all provide the (R)‐configurated product in the reaction of chalcon (Ia) with Et3Al.
ChemInform Abstract: Asymmetric Domino Nitro‐Michael/Horner—Wadsworth—Emmons Reaction for Disubstituted Cyclohexenecarboxylate Annulation: Efficient Synthesis of Dipeptidyl Peptidase IV Inhibitor ABT‐341 and Influenza Neuraminidase Inhibitor.
Authors: Weng Jiang , Li Jun‐Ming , Li Feng‐Quan , Xie Zhi‐Sheng , Lu Gui
Published: November 2012

Under optimized conditions using a prolinol‐derived catalyst, DABCO as base, and a lithium salt as additive, 4,5‐disubstituted cyclohexenecarboxylates are obtained from the reaction of α,β‐unsaturated aldehydes with nitro phosphonates with up to 92% enantioselectivities and varying diastereoselectivities (yields of pure diastereomers are given).
ChemInform Abstract: Semisynthetic Peptide—Lipase Conjugates for Improved Biotransformations.
Authors: Palomo Jose M. , et al. et al.
Published: November 2012

The creation of semisynthetic lipases by site‐specific chemical incorporation of tailor‐made peptides on the lid‐site of three different cysteine‐BTL variants on fast thiol‐disulfide exchange ligation is described.
ChemInform Abstract: Palladium(II)‐Catalyzed Cycloamidination via C(sp2)—H Activation and Isocyanide Insertion.
Authors: Wang Yong , Zhu Qiang
Published: November 2012

2‐(2‐Aminophenyl)indoles and aliphatic or aromatic isocyanides are transformed to tetracyclic fused pyridine derivatives under optimized conditions using cupric trifluoroacetate as oxidant under an inert atmosphere.
ChemInform Abstract: Lanthanide Replacement in Organic Synthesis: Luche‐Type Reduction of α,β‐Unsaturated Ketones in the Presence of Calcium Triflate.
Authors: Forkel Nina V. , Henderson David A. , Fuchter Matthew J.
Published: November 2012

A calcium‐mediated regioselective 1,2‐reduction of α,β‐unsaturated ketones affords the corresponding allylic alcohols.
ChemInform Abstract: Iron‐Catalyzed Hydrosilylation of Esters.
Authors: Bezier David , Venkanna Gopaladasu T. , Castro Luis C. Misal , Zheng Jianxia , Roisnel Thierry , Sortais Jean‐Baptiste , Darcel Christophe
Published: November 2012

In the presence of piano‐stool‐type iron catalyst IPC, under visible‐light activation and in the absence of a solvent, methyl alkanoates are converted to the corresponding alcohols.
ChemInform Abstract: The Direct Reductive Amination of Electron‐Deficient Amines with Aldehydes: The Unique Reactivity of the Re2O7 Catalyst.
Authors: Das Braja Gopal , Ghorai Prasanta
Published: November 2012

This direct reductive amination is highly chemo‐ and regioselective, tolerating a wide range of substrates.
ChemInform Abstract: Geminal Alkene—Alkyne Cross Metathesis Using a Relay Strategy.
Authors: Clark Joseph R. , French Jonathan M. , Jecs Edgars , Diver Steven T.
Published: November 2012

The separation of hydrophobic products derived from reactant (II) is sometimes difficult.
ChemInform Abstract: Palladium‐Catalyzed Arylation of α,β‐Unsaturated Weinreb Amides.
Authors: Kim Ko Hoon , Lee Sangku , Kim Se Hee , Lim Cheol Hee , Kim Jae Nyoung
Published: November 2012

The synthesis of β,β‐diaryl products is possible following a Heck‐type arylation with iodoarenes or via oxidative arylation in the presence of arenes.
ChemInform Abstract: Efficient Synthesis and Applications of 2‐Substituted Azulene Derivatives: Towards Highly Functionalized Carbo‐ and Heterocyclic Molecules.
Authors: Wu Chi‐Phi , Devendar Badugu , Su Hui‐Chi , Chang Ya‐Hui , Ku Chien‐Kuo
Published: November 2012

Reaction of cyclohepta[b]furans (I) with furan derivatives (II) or (XI) produces 2‐substituted azulenes.
ChemInform Abstract: Target‐Oriented Multifunctional Organocatalysis for Enantioselective Synthesis of Bicyclo[3.3.1]nona‐2,6‐dien‐9‐ones. A Formal Asymmetric Synthesis of Huperzine A.
Authors: Ding Xiao‐Hua , Li Xiang , Liu Dan , Cui Wei‐Chen , Ju Xuan , Wang Shaozhong , Yao Zhu‐Jun
Published: November 2012

A new organocatalytic enantioselective Michael addition of α‐aryl‐β‐ketoesters to unsaturated aldehydes affords bicyclononadienones under mild conditions.
ChemInform Abstract: Palladium‐Catalyzed Nitromethylation of Aryl Halides: An Orthogonal Formylation Equivalent.
Authors: Walvoord Ryan R. , Berritt Simon , Kozlowski Marisa C.
Published: November 2012

The method is successful for various substrates bearing functional groups.
ChemInform Abstract: Nickel‐Catalyzed Amination of Aryl Sulfamates and Carbamates Using an Air‐Stable Precatalyst.
Authors: Hie Liana , Ramgren Stephen D. , Mesganaw Tehetena , Garg Neil K.
Published: November 2012

A broad spectrum of sulfamates and carbamates is used which affords aromatic amines with good to excellent yields.
ChemInform Abstract: Preparation of N‐Arylamines from 2‐Oxo‐7‐azobicyclo[4.1.0]heptanes.
Authors: Barros M. Teresa , Dey Suvendu S. , Maycock Christopher D. , Rodrigues Paula
Published: November 2012

An organo‐catalytic domino aliphatic—aromatic transformation of azacyclohexanones into aromatic amines is developed.
ChemInform Abstract: Enantioselective Reduction of Ketoxime Ethers with Borane—Oxazaborolidines and Synthesis of the Key Intermediate Leading to (S)‐Rivastigmine.
Authors: Pakulski Marcin , Mahato Sanjit K. , Bosiak Mariusz J. , Krzeminski Marek P. , Zaidlewicz Marek
Published: November 2012

The reduction of some ketoxime O‐benzyl ethers (I), (IV) with borane is catalyzed by terpene oxazaborolidine NOB derived from (1R)‐nopinone to give the corresponding amines (II) and (V) with high enantioselectivities.
ChemInform Abstract: Ruthenium‐Catalyzed Oxidative C(sp2)—H Bond Hydroxylation: Site‐Selective C—O Bond Formation on Benzamides.
Authors: Thirunavukkarasu Vedhagiri S. , Hubrich Jonathan , Ackermann Lutz
Published: November 2012

The inexpensive complex RUMC is found to be optimal for the process.
ChemInform Abstract: Metal‐Free, NHPI‐Catalyzed Oxidative Cleavage of C—C Double Bond Using Molecular Oxygen as Oxidant.
Authors: Lin Riyuan , Chen Feng , Jiao Ning
Published: November 2012

Under the conditions shown, the application of toxic metals or overstoichiometric amounts of oxidant is prevented.
ChemInform Abstract: Novel One‐Pot Three‐Component Coupling Reaction with Trimethylsilylmethylphosphonate, Acyl Fluoride, and Aldehyde Through the Horner—Wadsworth—Emmons Reaction.
Authors: Umezawa Taiki , Seino Tomoya , Matsuda Fuyuhiko
Published: November 2012

A broad spectrum of substrates can be used for the procedure which enables a rapid access to α,β‐unsaturated ketones with high (E) or (Z) selectivity.
ChemInform Abstract: Simple and Convenient Access to α,α,α‐Trisubstituted Amides by Double Addition of Grignard Reagents to Acyl Cyanohydrins.
Authors: Boukattaya Fatma , Stanovych Andrii , Setzer Paul , Abid Souhir , Ammar Houcine , Pearson‐Long Morwenna S. M. , Bertus Philippe
Published: November 2012

A cheap, metal‐free, and general method for the synthesis of the title compounds is presented.
ChemInform Abstract: Synthesis and Insecticidal Activities of Novel Phthalic Acid Diamides.
Authors: Yan Tao , Li Yuxin , Li Yongqiang , Wang Duoyi , Chen Wei , Liu Zhuo , Li Zhengming
Published: November 2012

Compound (IIIa) is found to be more active against diamondback moths than the control chlorantraniliprole.
ChemInform Abstract: Oxidative Alkenylation of Aromatic Esters by Ruthenium‐Catalyzed Twofold C—H Bond Cleavages.
Authors: Graczyk Karolina , Ma Wenbo , Ackermann Lutz
Published: November 2012

The reaction proceeds highly regioselective and with complete (E)‐selectivity.
ChemInform Abstract: A Novel and Efficient Strategy for the Synthesis of Various Carbamates Using Carbamoyl Chlorides under Solvent‐Free and Grinding Conditions Using Microwave Irradiation.
Authors: Zare Hassan , Ghanbari Mohammad Mehdi , Jamali Marzieh , Aboodi Abdollah
Published: November 2012

Carbamoyl chlorides (III) can be easily generated from secondary amines and triphosgene.
ChemInform Abstract: Homocoupling of Benzyl Halides Catalyzed by POCOP—Nickel Pincer Complexes.
Authors: Chen Tao , Yang Limin , Li Liang , Huang Kuo‐Wei
Published: November 2012

A series of air‐ and moisture‐stable POCOP‐nickel pincer complexes is prepared and tested in the homocoupling of benzyl halides.
ChemInform Abstract: Synthesis and Carbonic Anhydrase Inhibitory Properties of Novel Bromophenols and Their Derivatives Including Natural Products: Vidalol B.
Authors: Balaydin Halis T. , Sentuerk Murat , Goeksu Sueleyman , Menzek Abdullah
Published: November 2012

Novel bromophenol derivatives (III) and (IV) are synthesized by condensation in PPA.
ChemInform Abstract: Highly Enantioselective Organocatalytic Formation of Functionalized Cyclopentane Derivatives via Tandem Conjugate Addition/α‐Alkylation of Enals.
Authors: Remes Marek , Vesely Jan
Published: November 2012

The novel title cascade Michael/α‐alkylation reaction operates for a wide range of functional groups.
ChemInform Abstract: A Novel and Efficient Tandem Aldol Condensation—Diels—Alder Reaction Pathway for the Direct Synthesis of Dehydrodecaline Derivatives.
Authors: Abaee M. Saeed , Mojtahedi Mohammad M. , Saberi Farveh , Karimi Ghazal , Rezaei M. Taghi , Mesbah A. Wahid , Harms Klaus , Massa Werner
Published: November 2012

A one‐pot procedure is presented for the aldol condensation of isophorone (I) with aromatic aldehydes followed by Diels—Alder reaction of the intermediate dienes [cf.
ChemInform Abstract: Unexpected One‐Pot Synthesis of Highly Conjugated Pentacyclic Diquinoid Compounds.
Authors: Coletti Alessia , Lentini Sara , Conte Valeria , Floris Barbara , Bortolini Olga , Sforza Fabio , Grepioni Fabrizia , Galloni Pierluca
Published: November 2012

Treatment of the quinone (I) with alkyl bromides in the presence of Cs2CO3 and ferrocene results in formation of new pentacyclic diquinoid compounds of type (III).
ChemInform Abstract: Palladium‐Catalyzed Direct Heteroarylations of Heteroaromatics Using Esters as Blocking Groups at C‐2 of Bromofuran and Bromothiophene Derivatives: A One‐Step Access to Biheteroaryls.
Authors: Fu Hai Yan , Zhao Liqin , Bruneau Christian , Doucet Henri
Published: November 2012

Direct coupling of various heteroaryls with bromofuran (I) or bromothiophene (XII) allows the access to various biheteroaryl systems.
ChemInform Abstract: Synthesis of Chiral Tetronic Acid Derivatives via Organocatalytic Conjugate Addition of Ethyl 4‐Chloro‐3‐oxobutanoate to Nitroalkenes.
Authors: Yan Yun‐yun , Lu Rui‐jiong , Wang Jin‐Jia , Xuan Yi‐ning , Yan Ming
Published: November 2012

Aryl, heteroaryl, and alkyl nitroalkenes are generally applicable in the transformation.
ChemInform Abstract: Synthesis and Anticancer Activity of a Series of Norcantharidin Analogues.
Authors: Tarleton Mark , Gilbert Jayne , Sakoff Jennette A. , McCluskey Adam
Published: November 2012

Several norcantharidin derivatives (IV) are synthesized by substitution of the hydroxy group as well as further modifications in the side chain.
ChemInform Abstract: A Photochemical Route to 2‐Substituted Benzo[b]furans.
Authors: Protti Stefano , Fagnoni Maurizio , Albini Angelo
Published: November 2012

Irradiation of 2‐chlorophenols or 2‐chloroanisoles with terminal alkynes allows a mild and environmentally friendly method to prepare a number of 2‐substituted benzofurans.
ChemInform Abstract: A General Method for Palladium‐Catalyzed Direct Carbonylation of Indole with Alcohol and Phenol.
Authors: Lang Rui , Shi Lijun , Li Dengfeng , Xia Chungu , Li Fuwei
Published: November 2012

Oxidative iodination and subsequent Pd‐catalyzed carbonylation in the presence of alcohols or phenols permits a direct esterification of indole substrates.
ChemInform Abstract: A Convenient Iodination of Indoles and Derivatives.
Authors: Hamri Salha , Rodriguez Jose , Basset Joan , Guillaumet Gerald , Pujol M. Dolors
Published: November 2012

A mild, efficient, and safe method for the iodination of indoles and azaindoles is developed.
ChemInform Abstract: An Efficient Copper‐Catalyzed Formation of Highly Substituted Pyrazoles Using Molecular Oxygen as the Oxidant.
Authors: Suri Mamta , Jousseaume Thierry , Neumann Julia J. , Glorius Frank
Published: November 2012

The atom‐economic method for the regioselective synthesis of tetrasubstituted pyrazoles tolerates a wide range of functional groups.
ChemInform Abstract: Facile and Rapid Synthesis of Polysubstituted Imidazoles by Employing Y(NO3)3·6H2O as Catalyst.
Authors: Karami Bahador , Dehghani Fatemeh Mohammadpour , Eskandari Khalil
Published: November 2012

A wide range of trisubstituted imidazoles (III) is synthesized by the present new yttrium‐catalyzed one‐pot reaction of benzil (I), aldehydes (II), and ammonium acetate under solvent‐free conditions.
ChemInform Abstract: Reaction of N‐Nitro‐O‐(4‐nitrophenyl)hydroxylamine with Phosphorus Pentoxide in the Presence of Nitriles. New Method for the Generation of Aryloxenium Ion.
Authors: Klenov M. S. , Churakov A. M. , Strelenko Yu. A. , Tartakovsky V. A.
Published: November 2012

A novel access to 5‐nitro‐1,3‐benzoxazoles (III) is described.
ChemInform Abstract: Eco‐Friendly Synthesis and Biological Evaluation of Substituted Pyrano[2,3‐c]pyrazoles.
Authors: Mandha Santhosh Reddy , Siliveri Sravanthi , Alla Manjula , Bommena Vittal Rao , Bommineni Madhava Reddy , Balasubramanian Sridhar
Published: November 2012

An initial condensation reaction between ethylacetoacetate and hydrazine, followed by addition of aromatic aldehydes (I) and malononitrile (II) to condensation product (III) furnishes the pyranopyrazoles (IV) in high yields.
ChemInform Abstract: Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. Part 4. 4H‐Pyrano‐[2,3‐b]naphthoquinones with Anticancer Activity.
Authors: Magedov Igor V. , et al. et al.
Published: November 2012

Synthetic analogues (IV) are investigated as mimetics of a diverse group of naturally occurring pyranonapthoquinones with promising anticancer activities.
ChemInform Abstract: Evaluation of Synthetic Acridones and 4‐Quinolinones as Potent Inhibitors of Cathepsins L and V.
Authors: Vieira Paulo C. , et al. et al.
Published: November 2012

A library of quinolinones is synthesized by employing microwave irradiation instead of conventional heating methods leading to significantly improved reaction times and yields.
ChemInform Abstract: New Quinoline‐5,8‐dione and Hydroxynaphthoquinone Derivatives Inhibit a Chloroquine Resistant Plasmodium falciparum Strain.
Authors: Hussain Hidayat , Specht Sabine , Sarite Salem R. , Hoerauf Achim , Krohn Karsten
Published: November 2012

Design, synthesis, and biological evaluation of novel title quinolinedione derivatives (V) are reported.
ChemInform Abstract: Rhodium(III)‐ and Ruthenium(II)‐Catalyzed Olefination of Isoquinolones.
Authors: Zhao Peng , Niu Rui , Wang Fen , Han Keli , Li Xingwei
Published: November 2012

Optimized conditions are elaborated for the coupling of N‐unprotected and N‐substituted isoquinolone substrates in the presence of terminal alkenes or internal alkynes, where a change concerning the catalyst is necessary.
ChemInform Abstract: New Synthesis and Promising Neuroprotective Role in Experimental Ischemic Stroke of ONO‐1714.
Authors: Pozo‐Rodrigalvarez Andrea , Gradillas Ana , Serrano Julia , Fernandez Ana Patricia , Martinez‐Murillo Ricardo , Perez‐Castells Javier
Published: November 2012

A modified route to title compound (IX) with improved overall yield is presented.
ChemInform Abstract: Cu(I)‐Catalyzed Atom Transfer Radical Cyclization of Trichloroacetamides Tethered to Eletron‐Deficient, ‐Neutral, and ‐Rich Alkenes: Synthesis of Polyfunctionalized 2‐Azabicyclo[3.3.1]nonanes.
Authors: Diaba Faiza , Martinez‐Laporta Agustin , Bonjoch Josep , Pereira Ana , Munoz‐Molina Jose Maria , Perez Pedro J. , Belderrain Tomas R.
Published: November 2012

A novel synthetic entry to the title compounds from readily available starting materials is described.
ChemInform Abstract: Rhodium‐Catalyzed Three‐Component Reaction Between Silylacetylene and Two Ketenes Leading to 1,3‐Enynes Bearing a Carboxylic Ester Group via Double Insertion of Ketenes.
Authors: Ogata Kenichi , Ohashi Itsuki , Fukuzawa Shin‐ichi
Published: November 2012

The use of other bulky silylacetylenes leads to lower yields.
ChemInform Abstract: Spirolactonized Si‐Rhodamine: A Novel NIR Fluorophore Utilized as a Platform to Construct Si‐Rhodamine‐Based Probes.
Authors: Wang Ting , Zhao Qing‐Jie , Hu Hong‐Gang , Yu Shi‐Chong , Liu Xiang , Liu Li , Wu Qiu‐Ye
Published: November 2012

The first synthesis of title compounds (IV) and (V) is presented.
ChemInform Abstract: Terpenoids from Loxocalyx urticifolius
Authors: He Dahai , Xu Xuemin , Zhou Yan , Deng Wenlong , Xia Bin , Ding Lisheng
Published: November 2012

isolation and structure elucidation of the new diterpenoids loxocalyxin A (Ia) and 13‐epiloxocalyxin A (Ib) and the new sesquiterpenoids loxocalyxin B (II) and C (III)
ChemInform Abstract: Design and Diastereoselective Synthesis of C‐2,C‐20‐Diaryl Steroidal Derivatives.
Authors: Rey Jullien , O'Riordan Timothy J. C. , Hu Haipeng , Snyder James P. , White Andrew J. P. , Barrett Anthony G. M.
Published: November 2012

The novel steroids (XI) are prepared as single isomers.
ChemInform Abstract: Synthesis of a Microcystis aeruginosa Predicted Metabolite with Antimalarial Activity.
Authors: Pena Stella , Scarone Laura , Manta Eduardo , Stewart Lindsay , Yardley Vanessa , Croft Simon , Serra Gloria
Published: November 2012

The synthesis of the hexacyclopeptide (I) as Microcystis aeruginosa predicted metabolite analogue of aerucyclamide B is performed by combining three heterocyclic building blocks using a macrocycle‐assembling methodology.
ChemInform Abstract: Microwave‐Assisted Synthesis of Novel Tetra‐O‐acetyl‐β‐D‐glucopyranosyl Thiosemicarbazones of Substituted Isatins.
Authors: Nguyen D. Thanh , Nguyen T. K. Giang
Published: November 2012

All products are purified by recrystallization.
ChemInform Abstract: Synthesis and Biological Evaluation of New Homocamptothecin Analogues.
Authors: Luo Yu , Yu Shanbao , Tong Linjiang , Huang Qingqing , Lu Wei , Chen Yi
Published: November 2012

Homocamptothecin analogues (IV) are prepared following a recently carried out total synthesis of camptothecin.
ChemInform Abstract: Unexpected Formation of Indenoisoquinoline Derivatives from Thia Analogues of Protoberberine Alkaloids.
Authors: Fodor Lajos , Csomos Peter , Molnar Judit , Zupko Istvan , Csampai Antal , Sohar Pal
Published: November 2012

Compound (IIb) shows moderate in vitro anti proliferative action against squamous skin carcinoma cell line (A431).
ChemInform Abstract: Synthesis and Biological Activity of Substituted 2,4‐Diaminopyrimidines that Inhibit Bacillus anthracis.
Authors: Nammalwar Baskar , Bunce Richard A. , Berlin K. Darrell , Bourne Christina R. , Bourne Philip C. , Barrow Esther W. , Barrow William W.
Published: November 2012

Racemic diaminopyrimidine derivatives (VI) are synthesized via a novel Heck coupling reaction and evaluated for activity against Bacillus anthracis.
ChemInform Abstract: Synthesis and Biological Evaluation of Novel Indolin‐2‐one Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors.
Authors: Dai Hou‐Ling , Shen Qiang , Zheng Jian‐Bin , Li Jing‐Ya , Wen Ren , Li Jia
Published: November 2012

Compounds (Ig), and (Ih) exhibit the most potent inhibitory activity.
ChemInform Abstract: Discovery of N‐(4‐Methoxy‐7‐methylbenzo[d]thiazol‐2‐yl)isonicatinamide, ML293, as a Novel, Selective and Brain Penetrant Positive Allosteric Modulator of the Muscarinic 4 (M4) Receptor.
Authors: Hopkins Corey R. , et al. et al.
Published: November 2012

Title compound (I) represents a novel muscarinic 4 (M4) receptor tool with superior in vivo PK properties compared to previously published molecules.
ChemInform Abstract: Tuning Crystal‐Phase and Shape of Fe2O3 Nanoparticles for Catalytic Applications
Authors: Mou Xiaoling , Wei Xuejiao , Li Yong , Shen Wenjie
Published: November 2012

Review: 172 refs.
ChemInform Abstract: Why Are Quasicrystals Quasiperiodic?
Authors: Steurer Walter
Published: November 2012

Review: 60 refs.
ChemInform Abstract: Coarctate Cyclization Reactions: A Primer
Authors: Young Brian S. , Herges Rainer , Haley Michael M.
Published: November 2012

Review: for the synthesis of pyridazines, pyrazoles, furans; 53 refs.
ChemInform Abstract: An Overview on Chemical Derivatization and Stability Aspects of Selected Avermectin Derivatives
Authors: Awasthi Atul , Razzak Majid , Al‐Kassas Raida , Harvey Joanne , Garg Sanjay
Published: November 2012

Review: 60 refs.
ChemInform Abstract: Polyarene Anions. Interplay Between Theory and Experiment
Authors: Eisenberg David , Shenhar Roy
Published: November 2012

Review: 137 refs.
ChemInform Abstract: Linear Aromatic Amide Foldamer‐Derived Supramolecular Architectures and Materials
Authors: Li Zhan‐Ting , Zhang Kang‐Da , Shi Zhu‐Ming , Wang Lu , Zhou Cen , Lu Ben‐Ye
Published: November 2012

Review: 73 refs.
ChemInform Abstract: Iridium‐Catalyzed Asymmetric Allylic Substitutions
Authors: Liu Wen‐Bo , Xia Ji‐Bao , You Shu‐Li
Published: November 2012

Review: 178 refs.
ChemInform Abstract: Catalytic Enantioselective Carbon—Carbon Bond Formation Using Cycloisomerization Reactions
Authors: Watson Iain D. G. , Toste F. Dean
Published: November 2012

Review: 240 refs.
ChemInform Abstract: Access to Molecular Complexity via Gold‐ and Platinum‐Catalyzed Cascade Reactions
Authors: Bhunia Sabyasachi , Liu Rai‐Shung
Published: November 2012

Review: 59 refs.
ChemInform Abstract: Practical Iron‐Catalyzed Atom/Group Transfer and Insertion Reactions
Authors: Chow Toby Wai‐Shan , Chen Guo‐Qiang , Liu Yungen , Zhou Cong‐Ying , Che Chi‐Ming
Published: November 2012

Review: 86 refs.
ChemInform Abstract: Complementary and Synergic Effects of Microwaves and Ultrasound in Metal‐Assisted Synthesis
Authors: Cintas Pedro , Carnaroglio Diego , Rinaldi Laura , Cravotto Giancarlo
Published: November 2012

Review: 40 refs.
ChemInform Abstract: Chiral 2,6‐Bis(5′,5′‐diphenyloxazoline)pyridine as an Efficient Ligand for Asymmetric Catalysis
Authors: Singh Pradeep K. , Singh Vinod K.
Published: November 2012

Review: 29 refs.
ChemInform Abstract: Dynamic Combinatorial Chemistry for Catalytic Applications
Authors: Breuil Pierre‐Alain R. , Reek Joost N. H.
Published: November 2012

Review: 42 refs.
ChemInform Abstract: General Strategies of Peptide Synthesis
Authors: Misicka Aleksandra
Published: November 2012

Review: 59 refs.
ChemInform Abstract: Applications of Pentafluorosulfanyl Substitution in Life Sciences Research
Authors: Welch John T.
Published: November 2012

Review: 71 refs.
ChemInform Abstract: Sulfur Oxygenation in Biomimetic Non‐Heme Iron‐Thiolate Complexes
Authors: McQuilken Alison C. , Goldberg David P.
Published: November 2012

Review: 85 refs.
ChemInform Abstract: Ultrasonics in Food Processing
Authors: Chandrapala Jayani , Oliver Christine , Kentish Sandra , Ashokkumar Muthupandian
Published: November 2012

Review: 69 refs.
ChemInform Abstract: New Opportunities in Crystal Engineering — The Role of Atomic Force Microscopy in Studies of Molecular Crystals
Authors: Chow Ernest H. H. , Bucar Dejan‐Kresimir , Jones William
Published: November 2012

Review: studies on polymorphs of Roy; 117 refs.
ChemInform Abstract: Nuclear Magnetic Relaxation of Liquids in Porous Media
Authors: Korb J.‐P.
Published: November 2012

Review: 57 refs.
ChemInform Abstract: Low Energy Ion Scattering and Secondary Ion Mass Spectrometry
Authors: Kruse Norbert , Chenakin Sergey
Published: November 2012

Review: 160 refs.
ChemInform Abstract: Moessbauer Spectroscopy
Authors: Stievano Lorenzo , Wagner Friedrich E.
Published: November 2012

Review: 91 refs.
ChemInform Abstract: Raman and UV/Raman Spectroscopies
Authors: Fan Fengtao , Feng Zhaochi , Li Can
Published: November 2012

Review: 125 refs.
ChemInform Abstract: Transient Techniques: Temporal Analysis of Products and Steady State Isotopic Transient Kinetics Analysis
Authors: Efstathiou Angelos M. , Gleaves John T. , Yablonsky Gregory S.
Published: November 2012

Review: 106 refs.