bluuebunny/crossref_metadata_2025 huggingface dataset:
Socio-economic and clinical correlates amongst hypertensive patients utilizing Complementary and Alternative Medicines (CAM) in a tertiary health institution in Niger Delta, Nigeria
Authors: Afamefuna F.U. , Yovwin D.G. , Anyanwu E.B.
Published: February 2025

Introduction: World over, patronage of CAM products is on the increase, even when more potent conventional therapies with less side effects are continually being researched and produced. This study aimed at determining the socio-economic and clinical correlates of hypertensive patients utilizing CAM products in a tertiary health institution in Delta State.
Materials and Methods: A total of 572 participants diagnosed with essential hypertension that met thestudy criteria were studied. A half of the participants (286) were on conventional treatment only (GroupA) while the other half (286) were on conventional treatment and CAM (Group B). Types of CAM products used, reasons for utilization, sources of CAM product knowledge and Family support for use were studied.
Results: Age group, marital status, higher levels of education, social class group, monthly level of income, body mass index, family history of hypertension and duration of hypertension were significantly associated with CAM utilization.
Conclusion: Family influence, higher body mass index as well as the duration of hypertension are strong predictors of utilization of CAM products amongst hypertensive patients.
Determination of neurophysiological P300 and P50 in patients with schizophrenia at a tertiary hospital in Sokoto, Nigeria
Authors: Adebisi A.S. , Onwuchekwa C. , Usman U.Z. , Shiitu B.S.
Published: February 2025

Introduction: Schizophrenia is a severe and complex mental disorder. It currently lacks an objective biological diagnostic test. Neurophysiological markers like P300 and P50 event-related potentials have shown some diagnostic usefulness in previous studies. However, very few of these studies have been done among Africans. The objective of the study was to evaluate neurophysiological P300 and P50 eventrelated potentials in 70 schizophrenia patients and 70 healthy controls at a tertiary psychiatric hospital in Sokoto, Nigeria.
Materials and Methods: The instruments used were the Electroencephalogram (EEG) machine, laptop with installed auditory P300 and P50 tones, headphones, Positive and Negative Syndrome Scale (PANSS).
Results: Schizophrenia patients were significantly associated with higher amplitude of P300 and prolonged P300 peak latency auditory event-related potential compared to healthy controls (U = 1077.000, P=<0.001 and U= 1191.000, P=<0.001) respectively. Schizophrenia patients were also significantly more associated with higher P50 amplitude ratio (U= 1342.500, P=<0.001). The P300 event-related amplitude had the highest area under the curve of 0.78. P300 peak latency was the most specific (Specificity=0.93) while P50 ratio was most sensitive (Sensitivity=0.76). The determined cut-off points for P300 amplitude, P300 peak latency, and P50 ratio were 6.84μv, 445ms, and 0.89 respectively. There was a significant positive correlation between P50 ratio and age of participants among schizophrenia patients (rs=0.29, P=0.02).
Conclusion: The study has determined the cut-off points for P300 and P50 neurophysiological markers in patients with schizophrenia. These will serve as an adjunct for diagnosis and for forensic purposes in these patients. Further studies including neuroimaging, biochemical, and genetic aspects are recommended in African countries.
Analyzing the Key Factors for Effective Procurement Systems
Authors: Yornu Isaac Kofi , Dadzie Eric Boafo
Published: February 2025

This study investigates the multifaceted elements influencing the efficacy of procurement systems within Ghana's public sector. Recognising the critical role procurement plays in efficiently allocating resources, the research aims to identify and analyse the factors contributing to successful procurement processes in this context. Through a comprehensive examination of legislative frameworks, institutional structures, stakeholder engagement, and technological integration, the study seeks to offer insights into the challenges and opportunities faced by Ghana's public procurement systems.
By employing a mixed-methods approach, including surveys, interviews, and document analysis, the research endeavours to provide a nuanced understanding of the interplay between these factors and their impact on the overall effectiveness of procurement practices. The findings of this study are expected to contribute valuable knowledge to policymakers, practitioners, and researchers, facilitating informed decision-making and fostering continuous improvement in public procurement systems in Ghana
Nutrient composition and glycemic response of five species of yam (Dioscorea) commonly consumed in South-East Nigeria
Authors: Arulogun Temilade Wemimo , Ani Chinyere Inez , Ugwu Maryann Ogechi , Ugwuanyi Uzoamaka Genevieve , Maduforo Aloysius Nwabugo , Okwara Chinyere
Published: February 2025

Background: Diabetes is one of the leading causes of death in the world especially in developing nations and nutritional management of blood glucose levels is a targeted tool in its prevention and management.Objective: To determine the nutrient composition and glycaemic response of varieties of tubers diascoreaspp(yams) commonly consumed in south-eastern NigeriaMethods: The study adopted a cross sectional design and simple random techniques. Forty participants were recruited for the study andfive species of yam Dioscoreaspp (D.rotundata, D.cavennesis, D. alata and D. dumetoru (white and yellow)) were purchased from new market in Enugu and from a farm in Umuahia, Nigeria. They were sorted, peeled, washed, cooked to tender and analyzed using AOAC method. Glycemic response was determined by the method described by Joint FAO/WHO ExpertConsultation.A structured questionnaire was used to elicit information on socio-demographic and anthropometric indices from the respondents. The blood glucose test was done using Accu-check Active meter and strips.Results: The mean BMI of respondents was 21.05±1.39kgm-2 and 24.75±3.71kgm-2 for male and female respectively. A significant differences (p<0.05) was found in the proximate and micronutrient (vitamins and minerals) composition of the varieties of yam. The study revealed that white yam(D.rotundata) gave the highest glucose response (110.8mg/dl±6.63 and 102.4mg/dl±4.12)after 60 and 90 minutes respectively, while after 120 minutes, water yam(D.cavennesis)gave the highest (104mg/dl±6.10). However, both speciesof “Una”dioscoreadumentorumgave the lowest glucose response.Conclusion: The variations in the nutrient composition and glycemic response of the varieties of yam can be explored for better dietary management especially for diabetes patients.
Biofilm Inhibitory Activity of Nauclea latifolia, Ocimum gratissimum and Garcinia kola Extracts Against Enteroaggregative Escherichia coli
Authors: Aderibigbe S.A. , Kwasi D.A.
Published: February 2025

Background: Enteroaggregative Escherichia coli (EAEC), a biofilm-forming E. coli pathotype, is recognized as one of foremost causes of  diarrhea in children under five years old, traveller’s diarrhea and persistent diarrhea. Biofilm complicates treatment as it enhances the  pathogen’s ability to undermine host immune responses, often resulting in emergence of resistant mutant.
Objectives: In search for potential therapeutic leads against EAEC with less selection pressure, the study was designed to investigate  selected medicinal plants for biofilm inhibitory activity against EAEC.
Material and Methods: Pulverised dry plant materials of Nauclea  latifolia (leaf), Ocimum gratissimum (leaf) and Garcinia kola (seed) were macerated in acetone for 24 hrs. The supernatants were  concentrated at reduced pressure and dried in vacuo. Thereafter, varying concentrations (0.31-5.0 mg/mL) of the extracts were evaluated  for growth and biofilm inhibitory activities against EAEC 042 strain using the crystal violet-based biofilm assay method. Biofilm inhibitory data were analysed using 2-way ANOVA, while the most bioactive of the extracts was profiled by phytochemical analysis.  
Results: Nauclea latifolia reproducibly inhibited biofilm formation by greater than 30% (defined biofilm inhibition cut-off) while inhibiting  growth by under 10% (defined growth inhibition cut-off). The other two plants showed relatively weak biofilm inhibitory activities.  Phytochemical evaluation revealed the presence of alkaloids, tannins, steroids, saponins, flavonoids, and cardiac glycosides.
Conclusions:  Nauclea latifolia exhibited good biofilm inhibitory activity against EAEC 042 strain with less selection pressure. The plant  represents a potential source of novel antibiofilm compounds against enteroaggregative E. coli.
Effect of Semi-Synthetic Bases and Hydrophile-Lipophile Balance (HLB) Of Mixed Surfactants on In-Vitro Release Profile of Ibuprofen Suppositories
Authors: Adeleke A.A. , Oladimeji F.A.
Published: February 2025

Background: The emphasis on the use of surfactants in enhancing drug release from fatty suppository bases has always been on the concentration and type of surfactants. However, the Hydrophile-Lipophile Balance (HLB) of the surfactants added, the concentrations and the type of suppository base used have significant effects.Objective: The study aimed to evaluate the effect of HLB of incorporated mixed surfactants, the concentration, and the type of base used on the physical and release properties of Ibuprofen suppository formulations.Methodology: Ibuprofen suppositories (200mg) were prepared using Witepsol® H15, Suppocire® CM, Witepsol® W35, Witepsol® E85 semi-synthetic bases. Mixed surfactants (Span® 80 and Tween® 80) were added at 4 %w/w in varied ratios to give HLB values of 4.3 to 15.0, and at 2 and 6% w/w at optimum HLB. The suppositories' physical properties and release profiles were evaluated using established procedures.Results: The release followed Witepsol® W35>Witepsol® H15>Suppocire® CM>Witepsol® E85. Release from Suppocire® CM and  Witepsol® E85 was favored at lipophilic HLB while release from Witepsol® W35 and Witepsol® H15 was favored at hydrophilic HLB. There was a general increase in the release of Ibuprofen with the increase in the concentration of mixed surfactants at the optimum HLBs. The  release kinetics were majorly fitted for Higuchi’s kinetic model and followed Fickian and Non-Fickian (anomalous) drug transport  mechanisms depending on the HLB of the mixed surfactants.Conclusions: The HLB, concentration of mixed surfactants, and the type of base greatly influenced the variation in the release profile of the Ibuprofen suppository.
Physicochemical and Lipid Peroxidation Evaluation of Fabricated Extract from Securidaca longipedunculata Root Bark
Authors: Nnamani N.D. , Iginomwahia E. , Adedokun O.A.
Published: February 2025

Background: Modification of some crude extracts have improved the stability, functional properties and process ability of their bioactive.
Objective: To fabricate bioactive from Securidaca longipedunculata root bark and compare its activities with the crude extract.
Methods: Modified extract was fabricated from Securidaca longipedunculata root bark using microencapsulation and freeze-drying  technique, and evaluated.
Results: Fourier Transform Infrared Spectroscopy evaluation showed similar leading peaks in the crude and fabricated extracts,  indicating absence of chemical alteration from modification. Energy-Dispersive X-ray (EDX) of the fabricated extract revealed no new  detectable element from the EDX of the crude extract, indicating chemical similarities in the crude and fabricated extracts. Scanning  Electron Microscopy (SEM) of crude extract revealed flatbed surface with no observed particles, while SEM of fabricated extract revealed  distinct, larger and sharp-edged particles, indicating structural changes from modification. In comparison to crude extract, fabricated  extract showed controlled dissolution, starting with lower dissolution over 30 min, on to higher dissolution after 45 min. At 20 – 100 mcg /  ml actives, Vitamin E showed 60 – 80 % lipid peroxidation, while crude and fabricated extracts both showed 12 – 20 % lipid peroxidation,  indicating that modification did not significantly alter the antioxidant efficacy of Securidaca longipedunculata crude extract material.   
Conclusion: The physicochemical and biological properties of fabricated Securidaca longipedunculata root bark extract showed promise in fast delivery of bioactive. There is need for further in vivo studies to ascertain the therapeutic potential of this fabricated form.
Cobalt Modulates Healing of Gastric Ulceration in Male Wistar Rats: iNOS/COX-2 Crosstalk
Authors: Salami A.T. , Akpamu U. , Iyiola T.O. , Olaleye S.B.
Published: February 2025

Background: Information on the interplay between gastric iNOS and COX-2 expression by Cobalt (CoCl2) during gastro-protection is unclear.
Objective: Cobalt activities on iNOS and COX-2 interplay was investigated using Reserpine (RGU), and Pyloricligation (PLGU) gastric ulcer models.
Materials and Methods: In RGU, 50 Wistar rats grouped; 1-control, 2-ulcerated untreated (RUU), 3, 4, and 5 were ulcerated pre-treated  with 62mg/kg, 25mg/kg CoCl2 and 3.6mg/kg omeprazole for 5 days and sacrificed 3 and 8 hours after reserpine administration. In PLGU,  25 Wistar rats grouped; A-25mg/kg Cocl2, B-62mg/kg Cocl2, C-Cimetidine (36.88mg/kg), D-ulcerated untreated (UU), and E–control, were  pretreated for 8 days prior 18 hours pyloric-ligation. Thereafter, macroscopic gastric ulceration (GU), biochemical analysis with histology,  and immunohistochemistry were evaluated on excised stomach. Data were expressed as Mean+SEM, and p<0.05 was significant. 
Results:  In RGU model, significant increase in GU score, nitric oxide, lipid peroxidation, and degranulated mast cells but a decrease in sulfhydryl,  hydrogen peroxide levels in RUU by 3H and 8H were ameliorated by CoCl2. Histology revealed increased degranulated mast cells in the  RUU compared with CoCl2-treated groups. CoCl2 treatment significantly decreased gastric acid secretion, ulcer index, parietal cell count,  H+ /K+ATPase and Na+ /K+ATPase activities compared with UU. Gastric sulfhydryl, mucin, pepsin, with mucous cell count significantly  increased in CoCl2-treated groups compared with UU. Gastric iNOS positive reactivity was upregulated while COX-2 positive reactivity was  downregulated in CoCl2-treated groups compared with UU . 
Conclusion: Cobalt chloride exerted gastrointestinal cytoprotective action  via mast cell stabilization, mucus production, with modulated expressions of gastric iNOS and COX-2 reactivity at the ulcerated site.
Diversité des acariens ravageurs de la famille des Tetranychidae présents sur Manihot esculenta dans la commune de Brazzaville : état des lieux et perspectives
Authors: Okassa Mireille Belle Mbou , Louzeymo Jessica bénie , Bikouta Grâce Nianga , Lenga Arsène
Published: February 2025

Description du sujet: Les acariens phytophages sont responsables d’énormes pertes agricoles à travers le monde. Peu de données  récentes existent sur la biodiversité des Tétranyques présente sur la culture de manioc (Manihot esculenta) en République du Congo  (RC).
Objectif: L’objectif de cette étude est d’effectuer un état des lieux récent de la biodiversité des acariens Tétranyques présents sur le manioc.
Méthodes: Plusieurs prélèvements d’acariens ravageurs présents sur la culture de manioc doux ont été effectués dans la  commune de Brazzaville pendant une période de quatre mois.
Résultats: Les résultats obtenus ont mis en évidence une  surreprésentation (près de 80 %) des espèces appartenant au genre Mononychellus et Oligonychus identifiées sur le manioc. Pour la  première fois, l’espèce Eutetranychus orientalis a été observée en République du Congo.
Conclusion: L’inventaire des acariens ravageurs  présents sur la culture de manioc constitue l’une des premières étapes avant la mise en place des stratégies de lutte  biologique efficace contre ces bioagresseurs. Des alternatives aux pesticides pourront ainsi être proposées aux agriculteurs congolais,  car les effets négatifs de ces produits sur la santé humaine et l’environnement sont connus et de plus en plus décriés. 
 
English title: Diversity of destructive mites of the Tetranychidae family present on Manihot esculenta in the commune ofBrazzaville: status report and perspectives
Description of the subject: Phytophagous mites are responsible for enormous agricultural losses worldwide. Little recent data exist on  the biodiversity of spider mites present on cassava (Manihot esculenta) crops in the Republic of Congo (ROC).Objective: The aim of this study was to carry out a recent inventory of the biodiversity of spider mites present on cassava cropsMethods: Several samples of mites on sweet cassava crops were taken in the commune of Brazzaville over a period of four months.Results: The results showed an overrepresentation (almost 80 %) of species belonging to the genera Mononychellus and Oligonychus  identified on cassava. The species Eutetranychus orientalis was observed for the first time in the Republic of Congo.Conclusion: An inventory of cassava pests is one of the first steps before implementing an effective biological control strategy against  these pests. Alternatives to pesticides can be offered to Congolese farmers, as the negative effects of pesticides on human health and the environment are well known and increasingly questioned.
Musik Tradislonal Melayu Riau: Refleksi Sosial dan Budaya Masyarakat Melayu
Authors: Ritawati Tengku
Published: February 2025

Riau Malay traditional music is a cultural heritage that not only possesses high aesthetic value but also plays a crucial role in reflecting the social and cultural life of the Malay community. As a medium of cultural expression, this traditional music instills moral, spiritual, and cultural values. Through instruments such as gambus, rebana, serunai, gendang, and others, as well as lyrics rich in meaning, Riau Malay traditional music serves as a medium for conveying moral messages, strengthening interpersonal relationships, and preserving traditions that are an integral part of community life. Moreover, this music also acts as a symbol of resistance against the influence of globalization, safeguarding local cultural identity, and reinforcing a sense of pride in ancestral heritage. This study employs a qualitative approach with an ethnographic method to understand the role of Riau Malay traditional music in the social and cultural life of the community. The findings indicate that traditional music functions not only as entertainment but also as a means of communication, a reinforcement of social bonds, and an informal educational tool for the Malay community. Thus, Riau Malay traditional music remains relevant as a cultural heritage that must be preserved and developed for future generations.
Misiones jesuitas con pícaros de la pesca del atún en el Sur de España
Authors: Soto Artuñedo Wenceslao
Published: February 2025

Una de las primeras misiones que realizaron los jesuitas al instalarse en Andalucía fue responder a la petición de los duques de Medina Sidonia para acudir cada año a misionar entre los que acudían a trabajar en la pesca del atún los meses de mayo y junio en las almadrabas de Zahara de los Atunes (Cádiz). Era una dura misión entre desheredados de la sociedad, con los que llegaron a tener una buena sintonía y sobre los que ejercían el ministerio sacerdotal al tiempo que ayudaban en sus necesidades materiales, convivencia y socialización. Destacó el P. Pedro de León.
Eksploitasi Secara Ekonomi Terhadap Anak Ditinjau dari Aspek Hukum Pidana (Studi Kasus di Kota Jember)
Authors: Azzahrah Danurjati , Suyatna
Published: February 2025

Realita di masyarakat termasuk di kota Jember, adalah eksploitasi ekonomi anak sebagai pengamen dan pengemis. Hingga saat ini, eksploitasi ekonomi anak masih terjadi di beberapa tempat. Anak digunakan untuk meminta-minta kepada pengendara atau menjual barang-barang kecil seperti tisu atau barang lain kepada pengemudi saat mereka menunggu lampu hijau. Tujuan penelitian ini pertama, untuk mengetahui siapa pelaku eksploitasi ekonomi anak. Kedua, untuk mengetahui bagaimana pertanggungjawaban pidana pelaku eksploitasi ekonomi anak. Metode penelitian ialah pendekatan normatif – empiris dengan menganalisis peraturan perundang-undangan dan konsep hukum. Hasil penelitian bahwa di Kabupaten Jember, enam anak pengemis mengalami eksploitasi ekonomi karena kehilangan bapak atau tulang punggung keluarga, sehingga terpaksa bekerja di jalanan. Kesimpulan dari penelitian ini bahwa Pelaku eksploitasi ekonomi terhadap anak terdapat 2 kualifikasi, yaitu pleger dan doen pleger. Pertanggungjawaban pidana pelaku eksploitasi ekonomi terhadap anak hanya dibebankan kepada orang tua anak saja, baik sebagai pleger maupun doen pleger.
Medication Therapy Management and Medication Adherence For Geriatric Patients
Authors:   Pharmacist, independat research, Tennessee, USA, Patel Nirlepkumar
Published: February 2025

The aging population represents a significant global challenge that demands our immediate attention.
Treating elderly patients presents distinct difficulties, with research indicating that nearly 50% of these
individuals struggle with adherence to at least one of their prescribed medications. Ensuring medication
adherence is imperative for achieving optimal health outcomes, particularly among geriatric patients
who often face multiple chronic conditions and complex medication regimens. Pharmacists are pivotal in
enhancing medication adherence through Medication Therapy Management (MTM), a comprehensive
service designed to optimize therapeutic outcomes. MTM encompasses essential activities such as
medication reconciliation, identifying and resolving drug-related issues, and delivering patient education
tailored to individual needs. Pharmacists actively implement targeted interventions, including simplifying
medication regimens and adopting deprescribing strategies to alleviate financial burdens on patients.
Moreover, pharmacists collaborate closely with healthcare providers to ensure continuity of care and engage
in patient-centered communication that empowers older adults throughout their treatment journey. This
review paper highlights the critical non-dispensing roles of pharmacists, such as Drug Utilization Review
(DUR), and highlights various activities and advancements in geriatric care. Now more than ever, it is
essential to recognize and leverage pharmacists' expertise in caring for the aging population.
Clinical analysis of a patient with marfanoid phenotype and diverticular disease
Authors:   Omsk State Medical University, Omsk, Russia, Poltavtseva Anastasiya M. , Viktorova Inna A. ,   Omsk State Medical University, Omsk, Russia, Rozhkova Maria Yu. ,   Omsk State Medical University, Omsk, Russia, Petrenko Marina V. ,   Omsk State Medical University, Omsk, Russia, Ivanova Daria S. ,   Omsk State Medical University, Omsk, Russia
Published: February 2025

Тhe term "connective tissue dysplasia" (DST) in the territory of the post-Soviet space has become so firmly established in medical practice that many specialists do not seek to verify monogenic syndromes, often hiding behind the usual appearance of the patient "dysplasty". The clinical observation of a patient with signs of DST, who has been observed from a young age by various specialists with pain syndromes, has been operated on three times for abdominal pain syndrome, but no stable positive result has been obtained. Upon examination of a patient with complaints indicating pathology of the digestive system, signs of systemic connective tissue involvement were revealed (7 points in accordance with the Ghent criteria), that is, a marfanoid phenotype was established, in combination with visceral lesions such as transversoptosis, dolichosigma, diverticular disease and diverticulitis, which confirm the presence of hereditary connective tissue disorder (NST). From the OMIM database of hereditary human diseases, it is known that diverticula are characteristic of such NCDs as Marfan syndrome, Ehlers–Danlo syndrome, Coffin–Lowry syndrome, Williams–Behren syndrome, autosomal dominant polycystic kidney disease, between which a differential diagnosis was made. After analyzing all the data, it can be assumed that our patient has Ehlers–Danlo syndrome. It is known that it is a defect in the synthesis of collagen types I or Ⅲ or tenascin X that characterizes progressive intestinal damage in diverticular disease with the possibility of abdominal catastrophes (rupture of the intestine or diverticulitis with peritonitis), therefore, verification of the diagnosis using genetic research is especially important.
Similarity of the gastrointestinal mechanisms underlying the development of osteoporosis and diabetes mellitus
Authors:   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Doskina Elena V.
Published: February 2025

There is an annual increase in patients with diabetes mellitus (DM). Consequently, the number of patients with complications of diabetes mellitus is also increasing – diabetic polyneuropathy, osteoporosis (OP), etc. Diabetes mellitus and osteoporosis have many common pathogenetic links, especially from the gastrointestinal tract and the hepatobiliary system. Timely early initiation of therapeutic and preventive measures helps to prevent the development of complications in the form of fractures in patients with diabetoporosis and OP and DM. The selection of adequate hypoglycemic therapy is impossible without meticulous self-monitoring and assessment of glycemia. The choice of a blood glucose meter is an important part of the therapeutic training and treatment of a patient with diabetes mellitus, both in the initial stages and in the presence of complications.
Speech act theory a historical development
Authors: Abdulhamzah Ali
Published: February 2025

Speech act theory, from the perspective of pragmatics, is a concept that is continually developing within the realm of linguistics. While Austin and Searle’s models provided the conceptual frameworks that contribute to ongoing scholarship, contemporary research also identifies a need for further adapting established models as analysts examine issues impacting subjects, organizations, and nations in the 21st century. In this context, the primary objective of this article is to offer an overview of the historical evolution of Speech Act Theory and to illustrate how these theoretical evaluations enhance the dissertation's examination of speech acts as processes that impact distinct populations in diverse manners.
Female Employment in Kazakhstan: a Comparative Analysis
Authors: Kredina Anna , Yusupova Sabrina , Haris Muhammad , Kuanova Laura
Published: February 2025

Women's participation in paid employment is essential for economic and social progress. This article aims to analyze the employment and economic activity of women in Kazakhstan to identify labor market problems. By examining global gender wage gaps and employment rates with a focus on Kazakhstan, the review highlights persistent inequalities and the effectiveness of support programs. The research shows that education significantly enhances women's employment opportunities, with higher educational attainment correlating with increased workforce participation and better pay. However, cultural attitudes often hinder full integration, as traditional gender roles and societal expectations continue to influence career choices and opportunities. Descriptive statistics and histograms illustrate vital trends, such as high employment rates among women over 15 and a significant gender wage gap. Progress in increasing women's wages is evident, yet disparities persist, particularly in high-paying industries where women are underrepresented. The results underscore the need for continued efforts to achieve full gender equality in the labor market. Recommendations include implementing policies to ensure equal pay for equal work, supporting vocational training and career growth for women, and conducting public awareness campaigns to challenge long-held stereotypes. By addressing these issues, the study aims to improve working conditions for women, reduce the gender pay gap, and enhance their economic participation, ultimately contributing to broader economic development.
Los discursos de odio por género en redes sociales frente a mujeres víctimas de violencia familiar en México: ¿libertad de opinión y de expresión?
Authors: Rangel Romero Xochithl Guadalupe , Viera Gutiérrez Fátima Elizabeth , Cuellar Ochoa Claudia Elizabeth
Published: February 2025

La violencia en contra de las mujeres es una realidad en México. Especialmente derivado del uso de la tecnología y plataformas digitales, hoy existe una especial situación que reproduce el continnum de violencia, como lo son: los discursos de odio que se facilitan en redes sociales bajo el amparo de una legislación que apenas comienza. Este trabajo, busca explicar con base en una metodología cualitativa, de revisión bibliográfica y legislativa, la existencia del discurso de odio y procurar entender si éstos discursos, se ajustan o no al derecho humano de libre opinión y de expresión.
The new climatic normals and their impact on bioclimatic indices. Case study: Oradea (Romania)
Authors: HAIDU Ionel , IONAC Nicoleta , IRAȘOC Adrian
Published: February 2025

This study examines the impact of new climatic normals (1991–2020 vs. 1961–1990)
on bioclimatic indices in Oradea, Romania, highlighting the dynamic relationship between climatic
variability and bioclimatic stress. The research focuses on three key indices: Effective-Equivalent
Temperature (EET), Temperature-Humidity Index (THI), and Wind Chill Index (WCI), selected
for their relevance in reflecting bioclimatic discomfort and risk. The results reveal a gradual
increase in air temperatures (+0.91°C annually), with more pronounced warming during summer
(+1.33°C to +1.64°C) and winter (+2.29°C in January). These changes influence bioclimatic
perceptions, with THI-min values shifting from "cold" to "cool" in summer months and THI-max
in August evolving from "warm" to "very warm." The study identifies significant trends: the
frequency of extreme maximum bioclimatic values has increased, while extreme minimum values
have decreased, reflecting intensified heat stress. While WCI and WCET show relative stability
due to wind's moderating effect, their influence diminishes, leading to increased thermal stress.
Future projections suggest that bioclimatic trends will continue to rise, with THI values potentially
aligning with mean air temperatures by 2118, indicating a stronger bioclimatic impact of
warming. This research emphasises the necessity of addressing these changes in regional
planning and public health strategies. It also highlights the broader implications for other
Romanian regions, where temperature increases are more significant, and stresses the
importance of further studies to assess bioclimatic impacts nationwide.
Is digitalization a good roof for sustainability reporting?
Authors: ŞTEFĂNESCU Cristina Alexandrina , NISTOR Cristina Silvia
Published: February 2025

This study explores the emerging path toward sustainability reporting and the under-
lying assumption that digitalization as a roof over all other factors (governance, economic,
environmental, social, and/or national culture) might support countries in enhancing
sustainability reporting. It approaches the newsworthiness of the topic by grounding on a
combination of stakeholders and resilience theory from both theoretical and empirical
perspectives. The research design relies on simple OLS regression and additional robustness and
heterogeneity tests that ensure the reliability and trustworthiness of the results. The findings
reveal that countries that widely adopted digital technologies also enhanced their sustainability
reporting. These countries exhibit as well environmental health and ecosystem vitality and
perform well in their economic progress. Sub-sample analysis reveals that digitalization was not
an enhancer of sustainability reporting practices for advanced countries but was a significant
driver for emerging ones.
Connecting nature and technology: using artificial intelligence to plan greener cities
Authors: POPESCU Oana-Cătălina , TACHE Antonio-Valentin , PETRIŞOR Alexandru-Ionuţ
Published: February 2025

The field of spatial planning uses digital technologies as support for planning and
decision-making activities. Recently, artificial intelligence technologies started to be used also in
green infrastructure planning to allow better decisions and to find solutions to mitigate climate
changes especially in urban areas. Optimization algorithms are used to plan green infrastructure
at all scales, from the level of a tree to residential and other urban green and natural spaces.
Therefore, the main objective of this study is to outline the necessity of implementing AI
technology in urban areas to improve the life of inhabitants and to increase the sustainability of
the city. Besides optimization algorithms as AI tools, the study presents a large range of tools
that can be used in the management of urban green infrastructure. In the urban context, these
new technologies that can be connected to the nature of the city in the form of a digital network
containing collected information from different sources. The conclusion is that the digital progress
must include the nature of the city. The research comes in the context of the opportunity to plan
green belts around Romanian cities and finding their optimal locations using the new digital
technologies.
Saproxylic beetles from the dead wood of the Plaiul Fagului Reserve, Republic of Moldova
Authors: BACAL S. , BUȘMACHIU G.
Published: February 2025

In 2024, the coleopteran species of the strictly protected area of the Plaiul Fagului
Reserve were studied using the method of trunk traps and direct collections from logs. A total of
64 coleopteran species from 31 families were revealed. Among these, the species Corticeus
unicolor Piller and Mitterpacher, 1783, Cis boleti (Scopoli, 1763) and Nematodes filum (Fabricius,
1801) are firstly reported for the fauna of the Republic of Moldova. Among the rare species
recorded in the old forest, stand out saproxylic species Bothrideres bipunctatus, Corticeus
fasciatus, Gnorimus nobilis, Megatoma undata, Omoglymmius germari, Oxylaemus cylindricus,
Platydema dejeanii, Rosalia alpina and Xylophilus testaceus. The old monodominant beech forest
and sessile forest in combination with elm, hornbeam, ash and cherry in the Plaiul Fagului
Reserve, is very important for the conservation of biodiversity as well as saproxylic coleoptera
from the central European temperate zone. The saproxylic species registered in the reserve
indicate a rare fauna, specific to old forests of regional and European importance.
The Influence of Contribution and Effectiveness of Regional Taxes on Original Regional Income (PAD) in Palembang City
Authors: Towi Yo Vira , Gustini Emilia , Munandar Aris
Published: February 2025

This study aims to analyze the effect of contribution and effectiveness on local revenue (PAD) in Palembang City. The data used in this research is secondary data in the form of documentation and literature study. The research method used is multiple linear regression analysis. The results indicate that the contribution and effectiveness have a significant effect on local revenue (PAD). This research is expected to become additional literature on the topic of local revenue (PAD).
Parental Socio-Demographic Factors and Psychological Adjustment of Senior Secondary School Students in Rivers State, Nigeria
Authors: Isiguzo Blessing Chioma , Isiguzo Reginald Chika
Published: February 2025

The study investigated parental socio-demographic factors and psychological adjustment among senior secondary school students in Rivers State, Nigeria. Three research questions and three corresponding hypotheses guided the study. Ex-post factor research design was adopted in the study. The population of the study comprised all the 30,528 senior secondary school II (SS II) students in the 261 senior secondary schools in Rivers State, Nigeria. The sample for the study comprised 3,052 SS II students determined through the simple random sampling technique, using 10% of the population. Data were collected using the researcher’s constructed non-cognitive instrument of two sections titled ‘students’ Psychological Adjustment Questionnaire” (SPAQ) which was validated by experts in the area of Educational psychology and Measurement and Evaluation, University of Port Harcourt. Cronbach alpha method was used to establish the reliability of the instrument which yielded a value of.70. Data collected were analyzed using mean and standard deviation to answer the research questions while one-way ANOVA was used to test the null hypotheses at .05 level of significance. The result revealed that low income and low educational level of parents affect students’ psychological adjustment negatively. It was therefore recommended among others that government and non-governmental organizations should frequent schools in order to give scholarship to students of low parental income status in order to boost their psychological well being.
A New Perspective on Sperm Analysis Through Artificial Intelligence: The Path Toward Personalized Reproductive Medicine
Authors: A Gongora , T Barajas
Published: February 2025

Male infertility is a significant factor in approximately 40% of couples experiencing primary or secondary infertility, posing a major biomedical and social challenge. Traditional sperm evaluation, based on the World Health Organization (WHO) criteria, provides a basic assessment of semen concentration, motility, and morphology. However, these methodologies face considerable limitations, including inter- and intra-observer variability, limited functional and molecular insights, and the absence of integrative criteria that encompass clinical, genomic, and epigenetic data.In recent decades, artificial intelligence (AI) has emerged as a pivotal tool for analyzing large datasets, recognizing complex patterns, and developing predictive models. In reproductive medicine, AI is playing a transformative role by enhancing diagnostic and prognostic accuracy while paving the way for personalized reproductive healthcare. Machine learning and deep learning applications are automating processes that previously relied almost exclusively on human expertise, enabling an unprecedented level of precision in evaluating sperm morphology, motility, and function. This article presents a comprehensive and multidisciplinary review of AI applications in sperm analysis, spanning conventional methodologies and their limitations to advanced classification and predictive models. It also explores the integration of AI with “omics” technologies (genomics, transcriptomics, proteomics, and epigenomics), the development of microfluidic devices, and the adoption of big data techniques in clinical practice. The review concludes with a discussion on ethical considerations, the need
Exploring the Nexus Between Technological Innovation, Environmental Regulation, Human Capital, and Low-Carbon Economy
Authors: Guo Jianquan , Zhao Xuning
Published: February 2025

This paper examines the panel data from 43 countries along the “Belt and Road” Initiative from 2000 to 2022 against the backdrop of global green low-carbon economic development. First, it explores the mechanism of action between technological innovation (TN) and the low-carbon economy (LE) using a panel fixed effects model. Second, by introducing environmental regulation (ER) and human capital (EDU) as moderating variables, it constructs a panel threshold model to investigate the nonlinear moderating effects in the relationship between TN and low-carbon economic development. Finally, the paper further categorizes these countries into samples to analyze the potential heterogeneity of the aforementioned effects. The empirical results indicate that: (1) TN has a negative effect on the LE of countries along the “Belt and Road”; (2) ER plays a positive moderating role in the influence of TN on the LE of these countries, while EDU exhibits a negative moderating role. Further research reveals a significant double-threshold effect of EDU in the relationship between TN and the LE, indicating that the negative effects of TN on the LE diminish as EDU increases. (3) This threshold effect displays significant heterogeneity at different levels of economic development and EDU.
 
Received: 9 November 2024 | Revised: 20 December 2024 | Accepted: 23 January 2025
 
Conflicts of Interest 
The authors declare that they have no conflicts of interest to this work.
 
Data Availability Statement
The data that support this work are available upon reasonable request to the corresponding author.
 
Author Contribution Statement
Jianquan Guo: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing, Supervision, Project administration. Xuning Zhao: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Data curation, Writing - original draft, Writing - review & editing, Visualization.
Impact of age-related dendritic atrophy on evoked electrophysiological activity in neocortical layer 3 pyramidal neurons: a modeling study
Authors: Korogod Sergiy , Kulagina Iryna
Published: February 2025

With aging that is often accompanied by neurodegenerative disorders, morphological atrophy and abnormal changes in excitability progress in central neurons. Cellular mechanisms, which relate to the morphological and physiological features of aging neurons, remain poorly understood, partly due to methodological and ethical constraints hampering clinical and experimental studies. Computation experiments on biologically accurate models have become increasingly widespread complementary sources of data shading light on such mechanisms. In this work, we used a model of neocortical layer 3 pyramidal neuron with reconstructed dendritic arborization and reproduced the age-related morphological atrophy by virtual pruning of dendrites and reducing the dendritic spine density to a smaller or greater extent. The changes in the intrinsic electrical excitability of simulated cells were characterized by changes in the responses to a somatically applied depolarization current. With each destructive morphological alteration, doublet bursting observed in the intact neuron has changed for continuous spiking of a greater rate associated with greater dendrite atrophy. The observed firing patterns were basically like those earlier described for simulated atrophic hippocampal neurons having different overall dendritic morphology as well as biophysical properties and distribution of type-specific ion channels.

Keywords: computer models; pyramidal neuron; dendritic atrophy; firing patterns; aging
A Deteriorating Environment and the Security of Nations
Authors: Ogon Sunday , Etta Peter
Published: February 2025

The environment remains the theatre upon which
every human and non-human species interact for
their livelihood. The nature of this interaction
protects or deteriorate available natural environmental
resources causing cataclysmic relations within and among
nations as the resources that sustain their livelihood
incrementally nosedives due to indiscriminate use and
population surge. The misuse of these resources has
become a threat to global security of nations as seen in the
multidimensional natural disasters affecting the global
space today. Thus, the study interrogated the nexus
between a deteriorating environment and the security of
nations. Methodologically, the study is both quantitative
and qualitative as relevant documentary evidences were
used as data source. The study revealed that contemporary
environmental security challenges are a manifestation of
the indiscriminate exploitation of resources for the
purposes of industrialization and technological
advancement as well as ineffective government policies,
causing adverse climate conditions experienced in
different part of the globe. The study recommended
among others for the domestication and effective
monitoring of global policy responses among nations.
Posts and Pathways: Social Media and Migration
Authors: Furxhi Nevila , Toromëni Asunta
Published: February 2025

This paper provides a comprehensive literature
review on the relationship between social media
and migration. It discusses the role of social media
in shaping migration behaviors, experiences, and
outcomes, as well as its influence on pre-migration
planning, integration processes, and transnational
connections. The review categorizes research into three
main themes: social media in pre-migration information,
influence on migrants' incorporation into host societies,
and the preservation of transnational ties among
immigrant communities. Theoretical frameworks are
applied to understand these dynamics, particularly
affecting social capital (Bourdieu, 1986), transnationalism
(Glick Schiller et al., 1992), and agency (Castells, 2009). By
synthesizing interdisciplinary findings, this paper aims to
provide a conceptual foundation focusing on the
importance of social media in the migration process. The
conclusion suggests avenues for further exploration,
particularly concerning the implications of digital divides
on migrant experiences and highlights the implications of
social media interactions for both migrants and host
societies, ultimately suggesting directions for future
research.
GERMANY AND SUSTAINABLE DEVELOPMENT GOALS’ IMPLEMENTATIONS
Authors: Hesse R.
Published: February 2025

Among the main threats to humanity in early 2022, the UN named climate change, increased forest fires, deforestation for farms, pastures and urban expansion. These issues are part of the sustainable development goals / SDGs developed by the UN in 2015. If by 2030 these goals are not achieved by states, then the issues of climate conservation, biodiversity, deforestation, growing consumption of resources, etc., then humanity risks causing great harm to the planet.
       The positive experience in the implementation of the SDGs in Germany is important for other countries, especially countries with developing economies, in the context of the approval of the updated Sustainable Development Strategy, published on 10/1/2020 with the inclusion of new indicators. The updated Strategy covered all enterprises in the country (for example, BASF, BMW, Bosch, etc.). Based on the analysis and synthesis, the features of the new Sustainable Development Strategy, their implementation at German enterprises are identified, the author's assessment of the policy of the Federal Government is given. It is shown that the implementation of the Sustainable Development Goals means taking responsibility: for present and future generations, at the national and international levels