bluuebunny/crossref_metadata_2025 huggingface dataset:
Damage Assessment of Road Bridges Caused by Extreme Streamflow in Montenegro: Reconstruction and Structural Upgrading
Authors: Pejović Jelena , Serdar Nina , Pejović Radenko
Published: June 2022

The extreme river streamflow that occurred during floods in 2010 in Montenegro caused significant damage to infrastructure and road facilities. The most severe damages were located on bridges crossing the river Lim, where a rapid water level increase in several municipalities led to failure or damage of almost 20 bridges. In this paper, a damage assessment of four significantly damaged reinforced concrete (RC) bridges, located in the affected zone of 40 km, is conducted. One bridge in Berane (bridge 1) and three bridges located on roads upstream from Berane (bridges 2, 3, and 4) were analyzed. Extreme water levels and inadequate flow profiles caused great damage to the bridges of which the piers were not adequately founded. A scouring process under the foundation of piers and abutments located in the riverbed occurred due to surface erosion and degradation of alluvial sediments. Applied methods and techniques for reconstruction and structural strengthening of bridges are presented in detail as well as results of conducted analyses of the design reconstruction process. In order to design appropriate structural strengthening, nonlinear analyses of bridges due to the settlement of the piers were performed. The research findings can be used in the vulnerability assessment and reconstruction planning phases for other bridges in the considered zone.
Safety Risk Assessment of Prefabricated Buildings Hoisting Construction: Based on IHFACS-ISAM-BN
Authors: Wang Junwu , Guo Feng , Song Yinghui , Liu Yipeng , Hu Xuan , Yuan Chunbao
Published: June 2022

Prefabricated buildings that are more environmentally friendly have been vigorously promoted by the Chinese government because of the reduced waste and carbon emissions during the construction process. Most of the construction processes of prefabricated buildings are completed in the prefabricated component factory, but the safety risks during the hoisting process cannot be ignored. In this paper, the initial framework of a Bayesian Network (BN) is obtained from the combination of the improved Human Factors Analysis and Classification System Model (HFACS) and BN. The improved similarity aggregation method (SAM) is used to calculate the prior probability of BN, which can better summarize and deal with the fuzzy judgment of experts on risk accidents. The improved SAM can consider both the weight of experts and the relative consistency of their opinions, which is of great significance for improving the reliability of BN inputted data. This paper uses the construction project in Sanya, Hainan Province, to verify the validity of the model. The results show that the calculation results of the model are basically consistent with the actual situation. The safety risk of this project is relatively low, and the premise of unsafe behaviors and unsafe supervision are the key risk factors of the project. In addition to maintaining good construction conditions and workers’ healthy states, it is also necessary to carefully check the performance of tower cranes and equipment such as spreaders. During the operation process of the tower crane, workers should avoid walking or staying within the hoisting range.
Experimental Investigations of the Behavior of Stiffened Perforated Cold-Formed Steel Sections Subjected to Axial Compression
Authors: Shaker Fattouh M. F. , Mamdooh Zekriat , Deifalla Ahmed , Yehia Mohamed M.
Published: June 2022

Cold-formed steel sections are becoming popular for different steel structures, because they have a high resistance against different straining actions, with a minimal weight compared with hard steel sections. Recently, perforated cold-formed steel (PCFS) sections have been used in many applications, such as perforated upright storage racks. Experimental research into the behavior of steel storage rack uprights subjected to axial compression is presented in this paper. First, tensile tests determined the material qualities of the cold-formed steel uprights. Then, seventeen perforated specimens were examined under axial compression, with five different cross-sections, three different web heights and thicknesses, and varying lengths. The study’s goals were to find out how perforations affect the performance and failure mode of steel storage rack uprights, to discuss the interaction of distortional and global buckling, and to verify the accuracy of using the direct strength method (DSM) for predicting the ultimate strength before failure in buckling interactions for perforated uprights. It was found that the failure modes of perforated specimens with stiffeners generally cannot be well predicted using the direct strength method. However, when the modifications proposed by Xianzhong Zhao et al. are used, the accuracy is acceptable.
Attenuation of Muscle Damage, Structural Abnormalities, and Physical Activity in Respiratory and Limb Muscles following Treatment with Rucaparib in Lung Cancer Cachexia Mice
Authors: Pérez-Peiró Maria , Duran Xavier , Yélamos José , Barreiro Esther
Published: June 2022

Overactivation of poly (ADPribose) polymerases (PARPs) is involved in cancer-induced cachexia. We hypothesized that the PARP inhibitor rucaparib may improve muscle mass and reduce damage in cancer cachexia mice. In mouse diaphragm and gastrocnemius (LP07 lung adenocarcinoma) treated with PARP inhibitor (rucaparib,150 mg/kg body weight/24 h for 20 days) and in non-tumor control animals, body, muscle, and tumor weights; tumor area; limb muscle strength; physical activity; muscle structural abnormalities, damage, and phenotype; PARP activity; and proteolytic and autophagy markers were quantified. In cancer cachexia mice compared to non-cachexia controls, body weight and body weight gain, muscle weight, limb strength, physical activity, and muscle fiber size significantly declined, while levels of PARP activity, plasma troponin I, muscle damage, and proteolytic and autophagy markers increased. Treatment with the PARP inhibitor rucaparib elicited a significant improvement in body weight gain, tumor size and weight, physical activity, muscle damage, troponin I, and proteolytic and autophagy levels. PARP pharmacological inhibition did not exert any significant improvements in muscle weight, fiber size, or limb muscle strength. Treatment with rucaparib, however, improved muscle damage and structural abnormalities and physical activity in cancer cachexia mice. These findings suggest that rucaparib exerts its beneficial effects on cancer cachexia performance through the restoration of muscle structure.
A Platform of Patient-Derived Microtumors Identifies Individual Treatment Responses and Therapeutic Vulnerabilities in Ovarian Cancer
Authors: Anderle Nicole , Koch André , Gierke Berthold , Keller Anna-Lena , Staebler Annette , Hartkopf Andreas , Brucker Sara Y. , Pawlak Michael , Schenke-Layland Katja , Schmees Christian
Published: June 2022

In light of the frequent development of therapeutic resistance in cancer treatment, there is a strong need for personalized model systems representing patient tumor heterogeneity, while enabling parallel drug testing and identification of appropriate treatment responses in individual patients. Using ovarian cancer as a prime example of a heterogeneous tumor disease, we developed a 3D preclinical tumor model comprised of patient-derived microtumors (PDM) and autologous tumor-infiltrating lymphocytes (TILs) to identify individual treatment vulnerabilities and validate chemo-, immuno- and targeted therapy efficacies. Enzymatic digestion of primary ovarian cancer tissue and cultivation in defined serum-free media allowed rapid and efficient recovery of PDM, while preserving histopathological features of corresponding patient tumor tissue. Reverse-phase protein array (RPPA)-analyses of >110 total and phospho-proteins enabled the identification of patient-specific sensitivities to standard, platinum-based therapy and thereby the prediction of potential treatment-responders. Co-cultures of PDM and autologous TILs for individual efficacy testing of immune checkpoint inhibitor treatment demonstrated patient-specific enhancement of cytotoxic TIL activity by this therapeutic approach. Combining protein pathway analysis and drug efficacy testing of PDM enables drug mode-of-action analyses and therapeutic sensitivity prediction within a clinically relevant time frame after surgery. Follow-up studies in larger cohorts are currently under way to further evaluate the applicability of this platform to support clinical decision making.
Acetyl-CoA Synthetase 2 as a Therapeutic Target in Tumor Metabolism
Authors: Liu Mengfang , Liu Na , Wang Jinlei , Fu Shengqiao , Wang Xu , Chen Deyu
Published: June 2022

Acetyl-CoA Synthetase 2 (ACSS2) belongs to a member of the acyl-CoA short-chain synthase family, which can convert acetate in the cytoplasm and nucleus into acetyl-CoA. It has been proven that ACSS2 is highly expressed in glioblastoma, breast cancer, liver cancer, prostate cancer, bladder cancer, renal cancer, and other tumors, and is closely related to tumor stage and the overall survival rate of patients. Accumulating studies show that hypoxia and a low serum level induce ACSS2 expression to help tumor cells cope with this nutrient-poor environment. The potential mechanisms are associated with the ability of ACSS2 to promote the synthesis of lipids in the cytoplasm, induce the acetylation of histones in the nucleus, and facilitate the expression of autophagy genes. Novel-specific inhibitors of ACSS2 are developed and confirmed to the effectiveness in pre-clinical tumor models. Targeting ACSS2 may provide novel approaches for tumor treatment. This review summarizes the biological function of ACSS2, its relation to survival and prognosis in different tumors, and how ACSS2 mediates different pathways to promote tumor metastasis, invasion, and drug resistance.
Bias and Class Imbalance in Oncologic Data—Towards Inclusive and Transferrable AI in Large Scale Oncology Data Sets
Authors: Tasci Erdal , Zhuge Ying , Camphausen Kevin , Krauze Andra V.
Published: June 2022

Recent technological developments have led to an increase in the size and types of data in the medical field derived from multiple platforms such as proteomic, genomic, imaging, and clinical data. Many machine learning models have been developed to support precision/personalized medicine initiatives such as computer-aided detection, diagnosis, prognosis, and treatment planning by using large-scale medical data. Bias and class imbalance represent two of the most pressing challenges for machine learning-based problems, particularly in medical (e.g., oncologic) data sets, due to the limitations in patient numbers, cost, privacy, and security of data sharing, and the complexity of generated data. Depending on the data set and the research question, the methods applied to address class imbalance problems can provide more effective, successful, and meaningful results. This review discusses the essential strategies for addressing and mitigating the class imbalance problems for different medical data types in the oncologic domain.
Epstein-Barr Virus (EBV) Is Mostly Latent and Clonal in Angioimmunoblastic T Cell Lymphoma (AITL)
Authors: Bahri Racha , Boyer François , Halabi Mohamad Adnan , Chaunavel Alain , Feuillard Jean , Jaccard Arnaud , Ranger-Rogez Sylvie
Published: June 2022

The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL), a peripheral T lymphoma of poor prognosis in at least 90% of cases. The role of EBV in this pathology is unknown. Using next-generation sequencing, we sequenced the entire EBV genome in biopsies from 18 patients with AITL, 16 patients with another EBV-associated lymphoma, and 2 controls. We chose an EBV target capture method, given the high specificity of this technique, followed by a second capture to increase sensitivity. We identified two main viral strains in AITL, one of them associated with the mutations BNRF1 S542N and BZLF1 A206S and with mutations in the EBNA-3 and LMP-2 genes. This strain was characterized in patients with short post-diagnosis survival. The main mutations found during AITL on the most mutated latency or tegument genes were identified and discussed. We showed that the virus was clonal in all the AITL samples, suggesting that it may be involved in this pathology. Additionally, EBV was latent in all the AITL samples; for one sample only, the virus was found to be latent and probably replicative, depending on the cells. These various elements support the role of EBV in AITL.
Proton Therapy in the Management of Hepatocellular Carcinoma
Authors: Kobeissi Jana M. , Hilal Lara , Simone Charles B. , Lin Haibo , Crane Christopher H. , Hajj Carla
Published: June 2022

Proton radiation therapy plays a central role in the treatment of hepatocellular carcinoma (HCC). Because of the near-zero exit dose and improved sparing of normal liver parenchyma, protons are being used even in challenging scenarios, including larger or multifocal liver tumors, and those associated with vascular tumor thrombus. There is a mounting level of evidence that suggests that protons are superior to photons in terms of survival and toxicity outcomes, specifically the progression to liver failure. A randomized controlled trial comparing protons to photons is currently underway to verify this hypothesis.
A Scoring Model and Protocol to Adapt Universal Screening for Lynch Syndrome to Identify Germline Pathogenic Variants by Next Generation Sequencing from Colorectal Cancer Patients and Cascade Screening
Authors: Chambuso Ramadhani , Robertson Barbara , Ramesar Raj
Published: June 2022

Identification of germline pathogenic variants (PV) predisposing to Lynch syndrome (LS) is an important step for effective use of cascade screening of extended at-risk lineages, leading to reduced morbidity and mortality due to colorectal cancer (CRC). As a general rule, however, next generation sequencing (NGS, either of gene panels or whole exomes) is relatively expensive and unaffordable for general clinical use. In resource-poor settings, performing NGS testing on an entire cohort of CRC patients, even if limited to those under 50 or 60 years of age, still places an enormous burden on limited resources. Although family history can be a good indicator for LS testing, identifying at-risk family members and offering cascade screening may not benefit many patients/probands without an obvious family history. This article presents a novel program called Modified Ascertainment and follow-up Program (MAP) with a scoring model for LS ascertainment and molecular screening by NGS with diagnosis confirmation of PV and cascade screening. The goal is to improve LS ascertainment in light of the growing burden of early-onset CRC, particularly in low- and middle-income countries. Through MAP, judiciously applied molecular genetics will improve identification of PV predisposing to LS and cascade screening.
Application of Bioelectrochemical System and Magnetite Nanoparticles on the Anaerobic Digestion of Sewage Sludge: Effect of Electrode Configuration
Authors: Madondo Nhlanganiso Ivan , Tetteh Emmanuel Kweinor , Rathilal Sudesh , Bakare Babatunde Femi
Published: June 2022

Conventional anaerobic digestion is currently challenged by limited degradability and low methane production. Herein, it is proposed that magnetic nanoparticles (Fe3O4-NPs) and bioelectrochemical systems can be employed for the improvement of organic content degradation. In this study, the effect of electrode configuration was examined through the application of a bioelectrochemical system and Fe3O4-NPs in anaerobic digestion (AD). A microbial electrolysis cell with cylindrical electrodes (MECC) and a microbial electrolysis cell (MEC) with rectangular electrodes were compared against the traditional AD process. Biochemical methane potential (BMP) tests were carried out using digesters with a working volume of 800 mL charged with 300 mL inoculum, 500 mL substrate, and 1 g Fe3O4-NPs. The electrodes (zinc and copper) of both digesters were inserted inside the BMPs and were powered with 0.4 V for 30 days at 40 °C. The MECC performed better, improving degradability, with enhanced methane percentage (by 49% > 39.1% of the control), and reduced water pollutants (chemical-oxygen demand, total organic carbon, total suspended solids, turbidity, and color) by more than 88.6%. The maximum current density was 33.3 mA/m2, and the coulombic efficiency was 54.4%. The MECC showed a remarkable potential to maximize methane enhancement and pollution removal by adjusting the electrode configuration.
A Multicomponent Butyrylcholinesterase Preparation for Enzyme Inhibition-Based Assay of Organophosphorus Pesticides
Authors: Lonshakova-Mukina Victoria I. , Esimbekova Elena N. , Kratasyuk Valentina A.
Published: June 2022

A new method of producing butyrylcholinesterase (BChE) preparations, stable in storage and use, has been proposed. The BChE preparation is the enzyme co-immobilized with 0.2 M 5-5′-dithiobis (2-nitrobenzoic acid) in starch or gelatin gel. All experimental preparations retain enzyme activity for at least 300 d. The preparations based on gelatin gel show higher activity but lower sensitivity to the toxicants tested in this study compared to the starch gel-based preparations. A method has been proposed for integrated detection of anti-cholinesterase substances in aqueous solutions using the experimental preparation with immobilized BChE. After the additional incubation of the preparation with the immobilized enzyme in the solution of the analyte, the detection limits of malathion and pirimiphos-methyl determined using the IC20 values were below their maximum allowable concentrations—0.005 µM and 0.03 µM, respectively.
Decolorization and Oxidation of Acid Blue 80 in Homogeneous and Heterogeneous Phases by Selected AOP Processes
Authors: Palarčík Jiří , Krupková Olga , Peroutková Petra , Malaťák Jan , Velebil Jan , Chýlková Jaromíra , Dušek Libor
Published: June 2022

This paper is a kinetic study that compares the rate of decolorization and subsequently the mineralization of Acid Blue 80 in model dyeworks wastewater, both in the homogeneous phase using the Fenton and photo-Fenton reactions, UV-C and UVC/H2O2 processes, and in the heterogeneous phase, where the proven commercial photocatalysts P25, P90, and AV01 based on TiO2 were used. The influence of pH of the environment was studied and in the case of the Fenton reaction, the influence of the concentration of catalyzing Fe2+ ions on the rate of decolorization of the model wastewater was also studied. The optimal molar ratio of H2O2/Fe2+ was 10:1. For describing the reaction kinetics, first-order speed constants were best-suited. In all applied processes, the dye chromophore degraded, which was accompanied by a quantitative decolorization of the model wastewater. Subsequently, the mineralization of colorless intermediate products was studied through a decrease in COD or, more precisely, TOC. The mineralization efficiency in the homogeneous phase ranged between 18.6 and 97.1% after 24 h. In the case of heterogeneous photocatalysis, it ranged between 79.6 and 97.3% after 24 h, with efficiency declining in the order P90 > P25 > AV01.
Impact of Bentonite Clay on In Situ Pyrolysis vs. Hydrothermal Carbonization of Avocado Pit Biomass
Authors: Karod Madeline , Pollard Zoe A. , Ahmad Maisha T. , Dou Guolan , Gao Lihui , Goldfarb Jillian L.
Published: June 2022

Biofuels produced via thermochemical conversions of waste biomass could be sustainable alternatives to fossil fuels but currently require costly downstream upgrading to be used in existing infrastructure. In this work, we explore how a low-cost, abundant clay mineral, bentonite, could serve as an in situ heterogeneous catalyst for two different thermochemical conversion processes: pyrolysis and hydrothermal carbonization (HTC). Avocado pits were combined with 20 wt% bentonite clay and were pyrolyzed at 600 °C and hydrothermally carbonized at 250 °C, commonly used conditions across the literature. During pyrolysis, bentonite clay promoted Diels–Alder reactions that transformed furans to aromatic compounds, which decreased the bio-oil oxygen content and produced a fuel closer to being suitable for existing infrastructure. The HTC bio-oil without the clay catalyst contained 100% furans, mainly 5-methylfurfural, but in the presence of the clay, approximately 25% of the bio-oil was transformed to 2-methyl-2-cyclopentenone, thereby adding two hydrogen atoms and removing one oxygen. The use of clay in both processes decreased the relative oxygen content of the bio-oils. Proximate analysis of the resulting chars showed an increase in fixed carbon (FC) and a decrease in volatile matter (VM) with clay inclusion. By containing more FC, the HTC-derived char may be more stable than pyrolysis-derived char for environmental applications. The addition of bentonite clay to both processes did not produce significantly different bio-oil yields, such that by adding a clay catalyst, a more valuable bio-oil was produced without reducing the amount of bio-oil recovered.
Tetragenococcus halophilus Alleviates Intestinal Inflammation in Mice by Altering Gut Microbiota and Regulating Dendritic Cell Activation via CD83
Authors: Islam S. M. Shamsul , Ryu Hye-Myung , Sohn Seonghyang
Published: June 2022

Ulcerative colitis (UC) is one of the major subtypes of inflammatory bowel disease with unknown etiology. Probiotics have recently been introduced as a treatment for UC. Tetragenococcus halophilus (T. halophilus) is a lactic acid-producing bacterium that survives in environments with high salt concentrations, though little is known about its immunomodulatory function as a probiotic. The purpose of this study is to determine whether T. halophilus exerts an anti-inflammatory effect on intestinal inflammation in mice. Colitis was induced in C57BL/6J mice by feeding 4% DSS in drinking water for 7 days. T. halophilus was orally administered with DSS. Anti-inflammatory functions were subsequently evaluated by flow cytometry, qRT-PCT, and ELISA. Gut microbial composition was analyzed by 16S rRNA metagenomic analysis. DSS-induced colitis mice treated with T. halophilus showed less weight loss and significantly suppressed colonic shortening compared to DSS-induced colitis mice. T. halophilus significantly reduced the frequency of the dendritic cell activation molecule CD83 in peripheral blood leukocytes and intestinal epithelial lymphocytes. Frequencies of CD8+NK1.1+ cells decreased in mice with colitis after T. halophilus treatment and IL-1β levels were also reduced. Alteration of gut microbiota was observed in mice with colitis after administration of T. halophilus. These results suggest T. halophilus is effective in alleviating DSS-induced colitis in mice by altering immune regulation and gut microbiome compositions.
Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation
Authors: Gajewska Katarzyna A. , Haynes John M. , Jans David A.
Published: June 2022

Molecular transport between the nucleus and cytoplasm of the cell is mediated by the importin superfamily of transport receptors, of which the bidirectional transporter Importin 13 (IPO13) is a unique member, with a critical role in early embryonic development through nuclear transport of key regulators, such as transcription factors Pax6, Pax3, and ARX. Here, we examined the role of IPO13 in neuronal differentiation for the first time, using a mouse embryonic stem cell (ESC) model and a monolayer-based differentiation protocol to compare IPO13−/− to wild type ESCs. Although IPO13−/− ESCs differentiated into neural progenitor cells, as indicated by the expression of dorsal forebrain progenitor markers, reduced expression of progenitor markers Pax6 and Nestin compared to IPO13−/− was evident, concomitant with reduced nuclear localisation/transcriptional function of IPO13 import cargo Pax6. Differentiation of IPO13−/− cells into neurons appeared to be strongly impaired, as evidenced by altered morphology, reduced expression of key neuronal markers, and altered response to the neurotransmitter glutamate. Our findings establish that IPO13 has a key role in ESC neuronal differentiation, in part through the nuclear transport of Pax6.
In Search of the Holy Grail: Toward a Unified Hypothesis on Mitochondrial Dysfunction in Age-Related Diseases
Authors: Zhang Jun , Shi Yuguang
Published: June 2022

Cardiolipin (CL) is a mitochondrial signature phospholipid that plays a pivotal role in mitochondrial dynamics, membrane structure, oxidative phosphorylation, mtDNA bioenergetics, and mitophagy. The depletion or abnormal acyl composition of CL causes mitochondrial dysfunction, which is implicated in the pathogenesis of aging and age-related disorders. However, the molecular mechanisms by which mitochondrial dysfunction causes age-related diseases remain poorly understood. Recent development in the field has identified acyl-CoA:lysocardiolipin acyltransferase 1 (ALCAT1), an acyltransferase upregulated by oxidative stress, as a key enzyme that promotes mitochondrial dysfunction in age-related diseases. ALCAT1 catalyzes CL remodeling with very-long-chain polyunsaturated fatty acids, such as docosahexaenoic acid (DHA). Enrichment of DHA renders CL highly sensitive to oxidative damage by reactive oxygen species (ROS). Oxidized CL becomes a new source of ROS in the form of lipid peroxides, leading to a vicious cycle of oxidative stress, CL depletion, and mitochondrial dysfunction. Consequently, ablation or the pharmacological inhibition of ALCAT1 have been shown to mitigate obesity, type 2 diabetes, heart failure, cardiomyopathy, fatty liver diseases, neurodegenerative diseases, and cancer. The findings suggest that age-related disorders are one disease (aging) manifested by different mitochondrion-sensitive tissues, and therefore should be treated as one disease. This review will discuss a unified hypothesis on CL remodeling by ALCAT1 as the common denominator of mitochondrial dysfunction, linking mitochondrial dysfunction to the development of age-related diseases.
Epigenetic Regulation of Development, Cellular Differentiation, and Disease Progression/Protection in Adults
Authors: Ryznar Rebecca J. , Phibbs Lacie , Onat Erin , Van Winkle Lon J.
Published: June 2022

Epigenetic changes drive early embryonic and later stages of development [...]
Knowledge, Practice, and Associated Factors of Essential Newborn Care among Sudanese Women in Eastern Sudan
Authors: Al-Nafeesah Abdullah , Ahmed Mohammed Ahmed A. , Elhory Omer , Mahgoub Hyder M. , Hassan Bahaeldin A. , Al-Wutayd Osama , Adam Ishag
Published: June 2022

(1) Background: There is a high neonatal mortality rate in countries with low resources, especially sub-Saharan countries. There is no published data in Sudan on mothers’ knowledge and practice of essential newborn care. This study aimed to assess the maternal knowledge and practice of essential newborn care in Gadarif city, eastern Sudan. (2) Methods: A cross-sectional study was conducted in Gadarif city, eastern Sudan. Postnatal mothers (384) were recruited from postnatal and vaccination clinics. A structured questionnaire was used to collect the data. Mothers who responded to essential newborn care knowledge and practice items at a rate equal to 75% or above were classified as having good knowledge and practice. Logistic regression analysis was performed to identify the factors associated with essential newborn care knowledge and practice. (3) Results: In this study, 268 (66.4%) and 245 (63.8%) of the 384 participants had good knowledge and practice of essential newborn care, respectively. None of the investigated factors (age, residence, education, occupation, parity, antenatal care, and mode of delivery) was associated with knowledge and practice of essential newborn care with sociodemographic and obstetric factors. Mothers with poor knowledge were less likely to have good practices (adjusted odds ratios = 0.41; 95% CI (0.26–0.64)). The reported malpractices were giving dietary supplements to the babies (48.2%), mainly water (40.0%) and cow’s milk (43.2%), and putting substances on the umbilical cord (62.8%), with butter (92.1%) accounting for the majority. (4) Conclusion: In the present study, around two-thirds of the participants had good essential newborn care knowledge and practice. Poor knowledge was less likely to be associated with good newborn care practices. More research is needed to build baseline data for neonatal mortality reduction plans.
Attachment and the Development of Prosocial Behavior in Children and Adolescents: A Systematic Review
Authors: Costa Martins Mariana , Santos Carolina , Fernandes Marília , Veríssimo Manuela
Published: June 2022

(1) Background: One key assumption of attachment theory is the relationship between security and the development of prosocial behavior. A secure child is more likely to feel and show concern for another individual, resulting in higher levels of prosocial behaviors (defined as voluntary behavior intended to benefit others—e.g., helping, sharing, comforting). (2) Method: Using a systematic review of the literature (PROSPERO: CRD42022290706), 703 articles were identified (EBSCO databases), from which 16 were considered eligible by the first two authors (inter-reviewer agreement: 85.714%). The criteria for an article’s exclusion were as follows: samples of children/teens not living in natural contexts; studies on psychopathologies; intervention programs; qualitative designs; studies on development or the validation of measures; studies that did not reliably measure the variables studied. (3) Results and Discussion: The eligible studies revealed incongruous results about the potential associations between attachment security to mothers and fathers and prosocial behavior. More consistent and significant relationships were found between the quality of attachment and empathy, while the associations between attachment and prosocial behavior were inconsistent (e.g., nine articles revealed significant associations; seven did not). In six studies, empathy was revealed to play an important role as the mediator between attachment security and prosocial behavior. The limitations and future recommendations were discussed.
Pediatric Stroke due to Thoracic Outlet Syndrome Treated with Thrombolysis and Thrombectomy: A Case Report
Authors: Angappan Dhanalakshmi , Garrett McKinnon , Henry Candice , Riddle Art , Wilson Jenny L.
Published: June 2022

Thoracic outlet syndrome (TOS) is a condition that results from the compression of neurovascular structures as they exit the thorax. Arterial ischemic stroke can occur in TOS due to retrograde embolism from the subclavian artery. We describe a 15-year-old girl who presented with left hemiplegia after 2 weeks of right arm numbness and tingling. Imaging showed an acute ischemic stroke due to a right middle cerebral artery occlusion. She was treated with intravenous tissue plasminogen activator at 1.3 h and mechanical thrombectomy at 2.4 h with successful recanalization. Review of her neck computed tomography angiogram suggested a right subclavian artery aneurysm, and upper-extremity imaging also demonstrated distal thrombosis and fusion of right first and second ribs, which was consistent with thoracic outlet syndrome. Three days later, she underwent a right subclavian artery aneurysm repair, right brachial and ulnar artery thrombectomy, and first rib resection. Three months later, she demonstrated good neurologic recovery. TOS is an uncommon cause of stroke in children, which may be heralded by upper-extremity symptoms. Interventionalists should be aware of the possibility of vascular anomalies in children; however, this finding does not exclude the possibility of acute stroke intervention.
Characteristics of Child-Rearing Environments Related to Social Development in Early Childhood
Authors: Sawada Yuko , Katayama Toshiko
Published: June 2022

This study aimed to determine the characteristics of childrearing environments related to social development in early childhood. A questionnaire survey was conducted with the caregivers of children attending an urban preschool to identify the characteristics of the childrearing environment in relation to social development in early childhood. The TK Infant Development Test was used to assess social development. The Index of Child Care Environment (13 items in four domains) was used to assess the childrearing environment. Six of the items were used to assess parent–child interaction at home. The correlation coefficients between the social development and childrearing environment items were calculated. Multiple regression analysis was conducted with social development (DQ) as the dependent variable and the childcare environment items as the independent variables. Two types of analyses were conducted: forced entry (model 1) and stepwise (model 2). The results of our univariate and multivariate analyses showed a significant association between the social development items and childrearing environment items after adjusting for the target attributes. This finding suggests that an appropriate childrearing environment promotes social development in early childhood.
The Application of Geographical Information Systems and the Analytic Hierarchy Process in Selecting Sustainable Areas for Urban Green Spaces: A Case Study in Hue City, Vietnam
Authors: Linh Nguyen Hoang Khanh , Tung Pham Gia , Chuong Huynh Van , Ngoc Nguyen Bich , Phuong Tran Thi
Published: June 2022

In recent years, there has been growing awareness about the roles and benefits of urban green spaces (UGSs), particularly in the context of mitigating the negative effects of climate change, which have become increasingly serious. In Vietnam, the government has allocated considerable resources to the development of UGSs in many cities. However, regarding implementation, UGS development in Vietnam faces many challenges; many cities find it difficult to meet the set criterion regarding the number of green spaces per capita. This research was conducted in Hue City, which is known as one of the greenest cities in Vietnam. The results show that there are twenty-one UGSs in Hue City (with a total area of 88.67 ha). These are located primarily along the Huong River and around the Hue Imperial Citadel. However, under government stipulations, the current number of UGSs is not considered sufficient in proportion to the local population, and will not accommodate the future growth of the population. We applied the analytic hierarchy process (AHP) along with the participation of local residents, using six criteria to map potential areas for future UGS planning. In this, the distance from existing residential areas to potential UGS locations is the most important criterion. The suitability map identified 684 hectares of Hue City as highly suitable for UGSs. This research also proposes a scenario for UGS planning in Hue based on retaining the existing green spaces combined with creating another 35 green spaces, comprising a total area of 167 hectares. This is to meet the needs of local residents by 2030.
Preparation and Performance Study of Carboxy-Functionalized Graphene Oxide Composite Polyaniline Modified Water-Based Epoxy Zinc-Rich Coatings
Authors: Chen Zhonghua , Cai Yuande , Lu Yunyun , Cao Qi , Lv Peibin , Zhang Yiru , Liu Wenjie
Published: June 2022

Graphene oxide is obtained by oxidation of graphite followed by ultrasonic exfoliation. It is a two-dimensional layered material with a large number of oxygen-containing functional groups on its surface. Polyaniline is a conductive polymer and has a unique corrosion protection mechanism. In this study, carboxy-functionalized graphene oxide/polyaniline (CGO/PANI) composites with a lamellar structure were prepared by in situ polymerization. The lamellar layer was used to form a labyrinthine structure in the coating to effectively retard the penetration of corrosive media. The electrical conductivity of polyaniline can promote the formation of conductive pathways between zinc particles and improve the utilization of zinc powder. Polyaniline is also able to passivate the substrate, further improving the coating’s ability to protect steel substrates against corrosion. In this paper, the in situ polymerization of aniline on carboxy-functionalized graphene oxide flakes was confirmed by scanning electron microscopy (SEM), Fourier infrared spectroscopy (FT-IR), and X-ray diffraction (XRD), and the improvement of the corrosion resistance of the prepared composites on the epoxy zinc-rich coatings was evaluated by SEM, electrochemical impedance spectroscopy (EIS), and salt spray resistance tests. The results showed that aniline was successfully polymerized in situ on carboxy-functionalized graphene oxide, and the modified coating had significantly improved anticorrosive properties, where the best anticorrosive improvement was achieved when CGO: PANI = 0.03.
Effects of Nano TiC on the Microhardness and Friction Properties of Laser Powder Bed Fusing Printed M2 High Speed Steel
Authors: Liu Yan , Zhao Dingguo , Li Yue , Wang Shuhuan
Published: June 2022

In this work, TiC/M2 high speed steel metal matrix composites (MMCs) were prepared using the ball milling method and laser powder bed fusing process. By controlling the TiC content in TiC/M2HSS, the grain size, phase composition, and frictional wear properties of the samples were enhanced. The results showed that when TiC/M2HSS was supplemented with 1% TiC, the surface microhardness of the samples increased to a maximum value and the wear volume decreased by approximately 39%, compared to pure M2HSS. The hardness and friction wear properties of the TiC/M2HSS composites showed a decreasing trend as the TiC content increased, owing to an increase in internal defects in the samples, as a result of excess TiC addition. The physical phases of the TiC/M2HSS MMC samples prepared by LPBF were dominated by the BCC phase, with some residual FCC phases and carbide phases. This work explored the possibility of enhancing the frictional wear performance of TiC/M2HSS samples by controlling the TiC content.
Improvement of Heat Treatment Process on Mechanical Properties of FDM 3D-Printed Short- and Continuous-Fiber-Reinforced PEEK Composites
Authors: Wang Peng , Zou Bin
Published: June 2022

Due to the addition of short/continuous fibers with better mechanical properties, FDM 3D-printed short- and continuous-fiber-reinforced PEEK composites possess better performance than printed PEEK. However, the interlayer bonding performance becomes poor due to the layer stacking and weak fiber–resin interface adhesion. In this study, a heat treatment process was proposed to improve the interlaminar bonding properties of 3D-printed short- and continuous-fiber-reinforced PEEK composites. The effects of heat treatment temperature and time on the interlaminar shear strength, porosity and dimensional change of printed samples were studied by a single-factor experiment. Moreover, the thermal properties and fracture morphology of FDM 3D-printed fiber-reinforced PEEK composites before and after heat treatment were investigated to explore the toughening and strengthening mechanism. The experimental results showed that the mechanical properties of FDM 3D-printed fiber-reinforced PEEK composites improved by heat treatment process can be attributed to the improvement of crystallinity and interfacial bonding. The heat treatment process can also improve the infiltration and diffusion among adjacent filaments and layers, and further reduce the defects. The optimized heat treatment temperature and time were 250 °C and 6 h, respectively. The maximum ILSS of FDM 3D-printed short- and continuous-fiber-reinforced PEEK composites increased by 16 and 85% compared with untreated samples, respectively.
Study on Friction and Wear Properties of New Self-Lubricating Bearing Materials
Authors: Zhao Leijie , Li Jiahui , Yang Qian , Wang Yanhui , Zhang Xiliang , Li Hezong , Yang Zhinan , Xu Dong , Liu Jiwei
Published: June 2022

In this paper, friction and wear tests were carried out: 45# steel (carbon steel) was rubbed with aluminum bronze, aluminum bronze-based inlaid solid self-lubricating bearing (ISSLB) material, tin bronze, and tin bronze-based ISSLB material under different loads. The friction and wear properties (friction coefficient, wear amount and friction temperature) of the above four materials were studied. The friction and wear properties of the new self-lubricating bearing material and the traditional copper alloy under the same load were compared. The friction mechanism of each material in the friction process was discussed. The effect and mechanism of C-MoS2 composite solid lubricant on friction and wear properties were analyzed. Under the experimental loads of 100 to 500 N, the average friction coefficients of aluminum bronze-based ISSLB material were maintained in the range of 0.18~0.14, while the average friction coefficients of tin bronze-based ISSLB material were maintained between 0.26~0.20, which is much lower than those of copper alloy. The wear amounts of tin bronze-based ISSLB material were always in the range of 14.7~34.4 mg, which were much less than those of aluminum bronze-based ISSLB materials and copper alloy. The results show that the copper-based ISSLB materials possess excellent wear resistance, and the friction and wear properties of tin bronze-based ISSLB material are better than that of aluminum bronze-based ISSLB material. Therefore, if the copper-based ISSLB materials are applied to self-lubricating bearings, the friction and wear resistance of bearings will be greatly improved and the service life of bearings prolonged.
Synthesis of WS2 by Chemical Vapor Deposition: Role of the Alumina Crucible
Authors: Stand Neileth , Mendoza Cesar D. , Freire Fernando L.
Published: June 2022

The role of the alumina crucible for the tungsten disulfide (WS2) growth on silicon dioxide substrates (SiO2/Si) under atmospheric pressure chemical vapor deposition (APCVD) was investigated. Both synthesis and properties of the APCVD-WS2 depend on the number of growth cycles when using the same alumina crucible. It was discovered that there is an ideal condition for the material’s synthesis, which is characterized by an increase in the photoluminescence (PL) yield and larger WS2 triangles. It usually happens for the first three growth cycles. For the fourth cycle and beyond, the PL decreases gradually. Simultaneously, atomic force microscopy images revealed no important changes in the topography of the WS2 flakes. As a function of the number of synthesis cycles, the progressive decrease in PL yield could be associated with materials with a higher density of defects, as identified by the LA(M)/A1g(M)−LA(M) ratio from Raman data using the green line.
Bagworms in Indonesian Plantation Forests: Species Composition, Pest Status, and Factors That Contribute to Outbreaks
Authors: Lelana Neo Endra , Utami Sri , Darmawan Ujang Wawan , Nuroniah Hani Sitti , Darwo  , Asmaliyah  , Haneda Noor Farikhah , Arinana  , Darwiati Wida , Anggraeni Illa
Published: June 2022

The role of plantation forests will become more important in the future, along with the increasing demand for wood. However, pest infestation problems may represent significant obstacles to the development of sustainable forest plantations. Bagworms are one of the most important pests in Indonesian plantation forests. Outbreaks of bagworms have occurred in different tree species for wood or non-wood resources. This paper presents the first review of bagworms in Indonesian plantation forests. This review presents the diversity of bagworms, their pest status, and the factors affecting the outbreaks. More than 70 bagworm species were recorded in Indonesia, which is higher than the species richness recorded in neighboring countries. The subfamily Oiketicinae has the highest number of species, followed by Typhoniinae and Taleporiinae. The highest bagworm richness has been recorded in Western Indonesia, except for Papua, where many new species have recently been described. More than 10 species of bagworms have been reported as pests in Indonesian forest trees. Pteroma plagiophleps is currently considered the most important pest in the forestry sector because of the wide range of forest trees used as hosts. Bagworm outbreaks have been reported in forest trees since 1924. The first outbreak occurred only in pines in Sumatra. Currently, outbreaks occur in more host plants and on other islands. Bagworm outbreaks are influenced by multiple factors, such as the biology of the bagworms, their host plants and natural enemies, climate, and silvicultural practices.
Macrobenthic Assemblages, Distribution and Functional Guilds from a Freshwater-Dominated Tropical Estuary
Authors: Rahman Mohammad Khaled , Hossain Mohammad Belal , Majumdar Priyanka Rani , Mustafa M. Golam , Noman Mohammad Abu , Albeshr Mohammed Fahad , Bhat Eijaz Ahmed , Arai Takaomi
Published: June 2022

Assessment of benthic diversity and estuarine ecological quality is becoming increasingly important. Estuaries are not only highly productive and variable environments, but they are also areas of high anthropogenic perturbations. In this study, benthic macrofauna were sorted, identified and analyzed from a freshwater-dominated tropical estuary along the Bay of Bengal to assess their community structure, distribution and functional guilds, and to uncover the environmental drivers influencing their distributional patterns. Results revealed that the studied physio-chemical variables (DO, pH, alkalinity and temperature) were significantly varied (p < 0.05) among the sites. Capitella sp. was dominant (18%) of the forty morphospecies recorded, indicating organic richness of the area. The ANOVA results revealed that macrobenthic density differed significantly (p < 0.01) between the study locations, and diversity indices (Shannon diversity index, H′) also differed significantly (F4,12 = 5.89; p = 0.02). The benthic density decreased from the head to the mouth, which could be related to salinity fluctuations and large freshwater discharges. Upstream sites were completely segregated from downstream and mid-estuarine sites, according to cluster analysis (CA). The SIMPER results clarified the site grouping pattern, showing that Mysis-1 spp., Capitella spp. and Nephtys-1 were the most significant contributors. From the communities, five functional trophic groups were identified where deposit feeders were the most dominant (66.44%). Most of the macrobenthos had strong positive correlations with DO (r = 0.92) and water temperature (r = 0.86) and a negative correlation with soil pH (r = −0.28), per correlation and CCA analyses. Individually, soil pH (r = 0.88) and alkalinity (r = 0.898) showed strong positive correlation with Capitella sp. and Chironomus sp.2. The above results indicate that macrobenthos of this estuary do not follow the usual pattern of spatial distribution, and they are structured by DO, alkalinity and soil pH. In addition, dominance of some pollution indicator species (Capitella sp. and Chironomus sp.) and deposit feeders indicates a poor ecological condition of the estuary.