bluuebunny/crossref_metadata_2025 huggingface dataset:
Survival comparison of hepatocellular carcinoma patients treated with radioembolization versus nonoperative/interventional treatment
Authors: Thayer David , Noda Christopher , Charalel Resmi , Mills Abigail , Chang Randy , Tao Yu , Akinwande Olaguoke
Published: March 2018

Aim:
To compare the overall survival (OS) and liver cancer-specific survival of advanced-stage hepatocellular carcinoma (HCC) patients who received transarterial radioembolization (TARE) with those who received nonoperative/interventional treatment (NOT).
Materials & methods:
 A total of 12,520 HCC patients from the Surveillance, Epidemiology and End Results database were categorized by treatment with either radioembolization or NOT. Kaplan–Meier and multivariate Cox regression were conducted.
Results:
The TARE group had both a significantly longer median overall survival than the NOT group (TARE = 9 months; NOT = 2 months; p < 0.0001) and a significantly higher probability of liver cancer-specific survival (hazard ratio = 0.474).
Conclusion:
TARE appears to provide a significant survival advantage over the NOT population in advanced HCC patients.
DAMPAK MERGER DAN AKUISISI TERHADAP KINERJA KEUANGAN PERUSAHAAN
Authors: Mardianto Mardianto , Christian Natalis , Edi Edi
Published: March 2018

Tujuan dari penelitian ini adalah : 1) Mengetahui dampak merger dan akusisi terhadap kinerja keuangan perusahaan, 2) Memberikan rekomendasi kepada manajemen perusahaan dalam upaya kebijakan merger dan akusisi. Umumnya tujuan dilakukannya merger dan akuisisi adalah menjadi media untuk memperluas portofolio produk, masuk ke pasar yang baru, mendapatkan teknologi baru, akses R&D dan sumber daya yang memungkinkan perusahaan untuk lebih bersaing, bahkan di kompetisi global. Banyaknya merger dan akuisisi membuat kita percaya bahwa perusahaan menjadi lebih profitable. Efektifitas dan efisiensi usaha menjadi lebih baik, sehingga sinergi yang diharapkan dapat dicapai. Penelitian ini dapat diklasifikasikan sebagai penelitian dasar dan bersifat kuantitatif dengan menggunakan data sekunder dengan teknik purposive sampling pada perusahaan yang melakukan merger dan akuisisi pada tahun 2005 hingga 2016. Analisis data yang digunakan adalah uji pair t test melalui program SPSS sehingga menghasilkan usulan rekomendasi bagi pembuat kebijakan untuk upaya merger dan akusisi.

This study aimed to determine the effect of the merger and acquisition on the financial performance of companies. And provide companies manager an effort for merger and acquisition. Generally, this aimed at merger and acquisition is medium for extending in portfolio product, into new markets, get new technology, access R&D, and resources for enabling companies to better compete, even competed globally. The number of merger and acquisitions leads us to believe that the company is becoming more profitable. The effectiveness and efficiency of the business become better so that the expected synergy can be achieved. This study can be classified as basic and quantitative research using secondary data with purposive sampling technique on companies doing mergers and acquisitions in 2005 to 2016. Data analysis used is pair t-test through SPSS program so as to generate recommendations for policy maker in effort for merger and acquisitions.
HUBUNGAN DETEKSI DINI (PAP SMEAR) DENGAN KEJADIAN KANKER SERVIKS DI POLI OBGYN
Authors: Ramadini Indri
Published: March 2018

Cervical cancer is the number one killer in Indonesia, according to the Department of health RI 2010 cervical cancer to reach 100/100,000 per year. This figure will continue to rise 25% over the next 10 years if preventative measures are not undertaken.This type of analytical observational studies, cross sectional research study design, the number of samples 45 respondents. Sampling techniques is the Accidental sampling. Data obtained from the results of the univariate analysis and questionnaires with the frequency distribution and bivariat use chi-square statistic test, the value of p value < 0.05. The results showed the incedence cervical cancer (68,9 %) and respondents who never do early detection (pap smear) (88,9%). The statistical test showed that there was a significant correlation between early detection (pap smear) and the incidence of cervical cancer.

Kanker serviks merupakan pembunuh nomor satu di Indonesia, menurut Depkes RI tahun 2010 kanker serviks mencapai angka 100/100.000 per tahun. Angka ini akan terus meningkat 25% dalam kurun waktu 10 tahun mendatang jika tindakan pencegahan tidak dilakukan. Jenis penelitian analitik observasional, desain penelitian cross sectional study, jumlah sampel  45 responden. Teknik pengambilan sampel accidental sampling. Data diperoleh dari hasil kuesioner dan analisa secara univariat dengan distribusi frekuensi dan bivariat dengan menggunakan uji statistik chi-square, nilai p value < 0,05.Hasil penelitian menunjukkan kejadian kanker serviks (68,9 %) dan responden yang tidak pernah melakukan deteksi dini (pap smear) (88,9 %). Uji statistik menunjukan bahwa ada hubungan yang bermakna antara deteksi dini (pap smear) dengan kejadian kanker serviks. 
PENGARUH TEMAN SEBAYA, PENGETAHUAN, MEDIA MASA TERHADAP PERILAKU DIET MAHASIWI STIKES PAYUNG NEGERI PEKANBARU
Authors: Fitri Rahmi Pramulia
Published: March 2018

Background: Diet is actually a way of combining between 60-70% carbohydrate, 10-15% protein and 20-25% fat. Based on research conducted Sasti (2015) Indonesia specifically no exact figures regarding dietary behaviors in adolescents. The prediction is based on data the average prevalence of adolescents in Indonesia who do unhealthy diets found a figure of42.6%.Objective: to determine the relationship of peer influence, knowledge and the role of mass media on the behavior of student diet STIKes Payung Negeri Pekanbaru. Methodology: This type of research is quantitative analytical research with correlation design with cross sectional research usingtechnique stratified random sampling yaitu a population made up of units that have different characteristics orheterogeneous.The sample in this study sebayak 71 sophomore I DII Midwifery. The data analysis univariate and bivariate withtest chi-squareResults showed that the influence of peers(pvalue 0.046 <0.05 and POR = 3.725 and the influence of mass media exposure(pvalue 0.041 <0.05 and POR = 3.321) have a relationship significantly to the dietary behavior of respondents.Conclusions: there is a significant correlation between the influence of peers and mass media exposure to dietary behavior 

 

Diet yang sebenarnya adalah cara mengkombinasi antara 60-70% karbohidrat, 10-15% protein, dan 20-25% lemak. Berdasarkan penelitian yang dilakukan Sasti (2015) Indonesia secara khusus belum ada angka yang pasti mengenai perilaku diet pada remaja. Prediksi yang didasarkan data rata-rata prevalensi remaja di Indonesia yang melakukan diet tidak sehat ditemukan angka sebesar 42,6%.Tujuan penelitian : untuk mengetahui hubungan pengaruh teman sebaya, pengetahuan dan peran media masa terhadap perilaku diet mahasiswi STIKes Payung Negeri Pekanbaru. Metodologi : Jenis penelitian yang digunakan adalah penelitian analitik kuantitatif dengan Desain korelasi dengan pendekatan cross sectional peneliti menggunakan teknik Stratified Random Sampling yaitu suatu populasi terdiri dari unit yang mempunyai karakteristik yang berbeda-beda atau heterogen. Sampel dalam penelitian ini sebayak 71 orang mahasiswi tingkat I DII Kebidanan. Analisa data secara univariat dan bivariat dengan uji chi-squareHasil : menunjukan bahwa pengaruh teman sebaya (p value 0,046 < 0,05 dan POR = 3,725 dan pengaruh paparan media massa (p value 0,041 < 0,05 dan POR = 3,321)memiliki hubungan yang signifikan terhadap perilaku diet responden.Kesimpulan: terdapat hubungan yang signifikan antara pengaruh teman sebaya dan paparan media massa terhadap perilaku diet mahasiswi DIII Kebidanan TIKes PayungNegeri Pekanbaru.
KENYAMANAN DAN KEPUASAN PASIEN DALAM PROSES INTERAKSI PELAYANAN KEPERAWATAN DI RSUD PETALA BUMI
Authors: Agritubella Syafrisar Meri
Published: March 2018

The quality of service nursing influenced by satisfaction and comfort patients .2 of 6 indicators of quality is a cause of patients home force and did not choose the hospital treatment same time of need .This study aims to analyze comfort and satisfaction patients in the interaction nursing service hospital the 2016 petala year .The research is description analytic with samples were 123 patients who were hospitalized in installation .The analysis shows that the patients are in the elderly early ( 25,2 % ) , patients of the female sex ( 57,7 % ) , the senior secondary school / equivalent ( 68,3 % ) , of employment civil servants ( 43,9 % ) , the treatment to 1 - 2 ( 95,1 % ) , the third grade care ( 51,2 % ) , the majority of haripe 1-3 day care ( 73,2 % ) , payment methods patients in installation patient is bpjs ( 63,4 % ) , mostly located in a room a floor III ( 41,5 % ) , berda in the comfortable ( 52,03 % ) and most patients are in the satisfied ( 72,36 %). In the process interaction service nursing .Expected management hospitals can make the most of communication nurse through seminar activities and training related communication effective in interpersonal raising comfort and satisfaction patients

 

Rendahnya mutu pelayanan keperawatan dipengaruhi oleh kepuasan pasien. Pelayanan keperawatan yang bermutu menjadi alasan pasien untuk menggunakan pelayanan kembali. Pelayanan dikatakan bermutu apabila pasien merasa nyaman dan menimbulkan kepuasan serta melebihi harapan pasien. Penelitian ini bertujuan untuk mendiskripsikan dan menganalisis kenyamanan dan kepuasan pasien dalam  proses interaksi  pelayanan keperawatan di RSUD Petala Bumi Tahun 2016. Jenis penelitian ini adalah deskripsi analitik dengan sampel berjumlah 123 pasien yang berada di Instalasi rawat inap. Hasil analisis menunjukkan bahwa pasien berada pada kelompok Lansia awal (25,2 %),  pasien jenis kelamin perempuan (57,7%), tingkat pendidikan SLTA / Sederajat  (68,3%),  Jenis Pekerjaan PNS(43,9 %),  kelompok rawatan ke 1 – 2 (95,1%), kelompok perawatan Kelas III (51,2%),  mayoritas hari rawatan 1-3 hari  (73,2%), Cara Pembayaran pasien di Instalasi Rawat Inap adalah BPJS (63,4%), sebagian besar berada di ruang Lantai III (41,5%), berda pada kategori Nyaman (52,03%) dan sebagian besar pasien berada pada kategori puas (72,36%) dalam proses interaksi pelayanan keperawatan. Diharapkan manajemen rumah sakit dapat mengoptimalkan kemampuan komunikasi perawat melalui kegiatan seminar dan pelatihan terkait komunikasi yang efektif secara interpersonal sehingga meningkatkan kenyamanan dan kepuasan pasien
Fertilizer distribution flows and logistic costs in Brazil: changes and benefits arising from investments in port terminals
Authors: da Costa Simões Débora , Caixeta-Filho José Vicente , Palekar Udatta S.
Published: March 2018

This study analyzes the impact of anticipated investments to alter Brazilian port infrastructure on fertilizer flows and fertilizer transportation logistics costs using a linear programming model designed for the task. The most notable among these investments are directed toward accelerating port development in Brazil’s “Northern-Arc”, thereby increasing fertilizer supply to new markets opening throughout the country’s expanding agricultural frontier, particularly in northern Mato Grosso state, while increasing supply to existing markets. Results from model runs show that the anticipated port infrastructure investments should ensure nationwide fertilizer logistics savings of US$ 845 million over the 2017 through 2025 period. Although these estimated benefits are outstanding, the study indicates that further expansion of Brazil’s port system, particularly in the Northern-Arc, presents additional opportunities. Model projections were that in 2025, after all planned infrastructure improvements are operational, port terminals will be near full capacity, which should make planning for future projects a current priority.
Corporate social responsibility and small-medium sized enterprises: evidence from Greece
Authors: Pitoska Electra , Giannakis Konstantinos , Sdraka Dimitra
Published: March 2018

This paper is a qualitative empirical research of Greek Small and Medium-sized Enterprises (SMEs) and examines their dominant perceptions and attitudes towards Corporate Social Responsibility (CSR). The research was conducted in the Region of Western Macedonia, North Greece, via personal interviews based on a structured questionnaire, which was completed by 420 enterprises, with different business functions, and were randomly chosen from local Chamber registers. The results demonstrated that, as Greek SMEs in the periphery have not decided on a particular strategy for Social Responsibility practices, CSR is frequently defined as sponsorship or charity programmes. The research also revealed the restraining factors for SMEs in implementing CSR policies: financial cost, small size of enterprises, absence of specialized partners, and poor supporting role of public authorities. Whereas, the most significant non-financial goals for the enterprises attempting to implement CSR in Greece are: responsibility and respect to customers, promotion of sustainability, environmentally-friendly practices; human resources and protection of rights are less emphasized. Interestingly, more than 80% of the subjects hold that engaging in CSR practices in the current financial context is vital. With regard to the benefits resulting from CSR, the research demonstrated that: Enhancing ‘corporate image’, ‘business performance’, and ‘customer satisfaction’ are significant. Nevertheless, the research highlighted that implementing CSR strategies are rather positively than strongly correlated with the benefits deriving from CSR.
Monetary Operations and Islamic Banking in The GCC: Challenges and Options
Authors: Basu Ritu , Ananthakrishnan Prasad , Rodriguez Sergio
Published: March 2018

The assessment provides evidence of market segmentation across Islamic and conventional banks in the Gulf Cooperation Council (GCC), leading to excess liquidity, and an uneven playing field for Islamic banks that might affect their growth. Liquidity management has been a long-standing concern in the global Islamic finance industry as there is a general lack of Shari’ah compliant instruments that can serve as high-quality short-term liquid assets. The degree of segmentation and bank behavior varies across countries depending on Shari’ah permissibility and the availability of Shari’ah-compliant instruments. A partial response would be to support efforts to build Islamic liquid interbank and money markets, which are crucial for monetary policy transmission through the Islamic financial system. This can be achieved, to a large extent, by deepening Islamic government securities and developing Shari’ah-compliant money market instruments.
Non-linear water waves (KdV) equation by Painlevé property and Schwarzian derivative
Authors: Mateljevic Miodrag , Mostafa Attia
Published: March 2018

The Korteweg-de Vries (KdV) equation, a nonlinear partial differential
equation which describes the motion of water waves, has been of interest
since John Scott Russell (1834) [4]. In present work we study this kind of
equation and through our study we found that the KdV equation passes
Painleve?s test, but we could not locate the solution directly, so we used
Schwarzian derivative technique. Therefore, we were able to find two new
exact solutions to the KdV equation. Also, we used the numerical method of
Modified Zabusky-Kruskal to describe the behavior of these solutions.
Uniqueness part of the Schwarz lemma at the boundary
Authors: Örnek Bülent , Akyel Tuğba
Published: March 2018

In this paper, a boundary version of the uniqueness (or, rigidity) part of
the Schwarz lemma should be investigated. Also, new results related to inner
functions, inner capacities, and bilogaritmic concave majorants are
obtained.
A note on the group inverses of block matrices over rings
Authors: Zhang Hanyu
Published: March 2018

Suppose R is an associative ring with identity 1. The purpose of this paper
is to give some necessary and sufficient conditions for the existence and the
representations of the group inverse of the block matrix (AX+YB B A 0)
and M = (A B C D) under some conditions. Some examples are given to
illustrate our results.
Ciric-Berinde fixed point theorems formulti-valued mappings on α-complete metric-like spaces
Authors: Aydi Hassen , Felhi Abdelbasset , Sahmim Slah
Published: March 2018

The concept of Hausdorff metric-like has been initiated in [7]. Using this
concept, we introduce Ciric-Berinde type contractive multi-valued
mappings via ?-admissible mappings on metric-like spaces and we establish
several fixed point results. We show that many known fixed point results in
literature are simple consequences of our theorems. Our obtained results are
supported by some examples and an application.
Moore-Penrose inverse in indefinite inner product spaces
Authors: Radojevic Ivana , Djordjevic Dragan
Published: March 2018

We present the definition and some properties for the Moore-Penrose inverse
in possibly degenerate indefinite inner product spaces. The extensions of
appropriate results, given for matrices in Euclidean and nondegenerate
indefinite inner product spaces are established. All this is done by using
the concept of linear relations.
A fixed point theorem for a new class of set-valued mappings in R-complete (not necessarily complete) metric spaces
Authors: Baghani Hamid , Ramezani Maryam
Published: March 2018

In this paper, firstly, we introduce the notion of R-complete metric spaces.
This notion let us to consider fixed point theorem in R-complete instead of
complete metric spaces. Secondly, as motivated by the recent work of
Amini-Harandi (Fixed Point Theory Appl. 2012, 2012:215), we explain a new
generalized contractive condition for set-valued mappings and prove a fixed
point theorem in R-complete metric spaces which extends some well-known
results in the literature. Finally, some examples are given to support our
main theorem and also we find the existence of solution for a first-order
ordinary differential equation.
Second Hankel determinant problem for k-bi-starlike functions
Authors: Orhan Halit , Toklu Evrim , Kadıoğlu Ekrem
Published: March 2018

In this paper we introduce and study some properties of k-bi-starlike
functions defined by making use of the S?l?gean derivative operator. Upper
bounds on the second Hankel determinant for k-bi-starlike functions are
investigated. Relevant connections of the results presented here with
various well-known results are briefly indicated.
Partial domination - the isolation number of a graph
Authors: Caro Yair , Hansberg Adriana
Published: March 2018

We prove the following result: If G be a connected graph on n ? 6 vertices,
then there exists a set of vertices D with ?D?? n/3 and such that V(G) n
N[D] is an independent set, where N[D] is the closed neighborhood of D.
Furthermore, the bound is sharp. This seems to be the first result in the
direction of partial domination with constrained structure on the graph
induced by the non-dominated vertices, which we further elaborate in this
paper.
A mixed thinning based geometric INAR(1) model
Authors: Nastic Aleksandar , Ristic Miroslav , Janjic Ana
Published: March 2018

In this article a geometrically distributed integer-valued autoregressive
model of order one based on the mixed thinning operator is introduced. This
new thinning operator is defined as a probability mixture of two well known
thinning operators, binomial and negative binomial thinning. Some model
properties are discussed. Method of moments and the conditional least
squares are considered as possible approaches in model parameter estimation.
Asymptotic characterization of the obtained parameter estimators is
presented. The adequacy of the introduced model is verified by its
application on a certain kind of real-life counting data, while its
performance is evaluated by comparison with two other INAR(1) models that
can be also used over the observed data.
Second order infinitesimal bending of curves
Authors: Najdanovic Marija , Velimirovic Ljubica
Published: March 2018

We investigate a second order infinitesimal bending of curves in a
three-dimensional Euclidean space in this paper. We give the necessary and
sufficient conditions for the vector fields to be infinitesimal bending fields
of the corresponding order, as well as explicit formulas which determine
these fields. We examine the first and the second variation of some
geometric magnitudes which describe a curve, specially a change of the
curvature. Two illustrative examples (a circle and a helix) are studied not
only analytically but also by drawing curves using computer program
Mathematica.
A DFT study of the chemical reactivity of thiobencarb and its oxidized derivatives in aqueous phase
Authors: Mendoza-Huizar Luis
Published: March 2018

In the present work, the global and local reactivity of S-(4-chlorobenzyl)- N,N-diethylthiocarbamate (TB) and its oxidized derivatives (sulfone (TBSu) and sulfoxide (TBS) were analyzed. In addition, the chemical reactivities of the dechlorinated forms of TB (DTB), TBSu (DTBSu) and TBS (DTBS) were studied. The calculations were performed at the wB97XD/6- -311++G(2d,2p) level of theory in the aqueous phase. The condensed Fukui functions indicated that for TB and DTB, the most preferred sites for donating electron in a reaction are located on the S and N atoms, while the most reactive sites for accepting electrons are associated with the aromatic ring (AR). For TBS and DTBS, the more reactive sites are located on AR, S and AR for nucleophilic, electrophilic and free radical attacks, respectively. In the case of TBSu and DTBSu, the results showed AR to be the more reactive zone for the three kinds of attacks. These last results suggest that cleavage of the C?S bond in TB, TBS and their dechlorinated forms is favored by electrophilic attacks. Additionally, the obtained results suggest that in TB, it is plausible that the cleavage of the C?N is favored on attack of this molecule by electrophiles.
The impact of quality of service parameters to the subjective and objective video quality assessment
Authors: Stanojevic Danilo , Bondzulic Boban , Pavlovic Boban , Petrovic Vladimir
Published: March 2018

This paper deals with the delay, delay variation - jitter, packet loss rate
and bandwidth as quality of service parameters, in the form of four types of
video quality degradations. The impact of defined levels of degradation on
subjective impressions (given as mean opinion scores) is analyzed. ReTRiEVED
video dataset with publicly available subjective scores is used in the
analysis. Three full-reference measures are used for objective assessment of
video quality. The degree of consistency of subjective and objective quality
scores is shown through scatter plots and quantitative measures (linear
correlation coefficient and correlation of the ranks). Based on the
interpolation functions, quality of service parameters are mapped to
subjective experience. We show that jitter is a much more destructive effect
than other degradation types.
A brief overview of the distribution test grids with a distributed generation inclusion case study
Authors: Stanisavljevic Aleksandar , Katic Vladimir , Dumnic Boris , Popadic Bane
Published: March 2018

The paper presents an overview of the electric distribution test grids issued
by different technical institutions. They are used for testing different
scenarios in operation of a grid for research, benchmarking, comparison and
other purposes. Their types, main characteristics, features as well as
application possibilities are shown. Recently, these grids are modified with
inclusion of distributed generation. An example of modification and
application of the IEEE 13-bus for testing effects of faults in cases without
and with a distributed generator connection to the grid is presented.
The effect of meat and bone meal (MBM) on the nitrogen and phosphorus content and pH of soil
Authors: Nogalska Anna , Krzebietke Sławomir Józef , Zalewska Marta , Nogalski Zenon
Published: March 2018

A field experiment was conducted in 2011 – 2013 in Poland. The objective of this study was to determine the effect of increasing doses of meat and bone meal (MBM) on the mineral nitrogen (Nmin) and available phosphorus (P) content of soil and the soil pH. Changes in the content of NH4+-N, NO3--N and available P in soil were affected by MBM dose, experiment duration, weather conditions and crop species. Soil amended with MBM was more abundant in mineral N and available P. The lowest concentration of NO3--N and the highest concentration of NH4+-N were noted in the first year of the study, because the nitrification process requires a longer time. MBM had no influence on the accumulation of Nmin in soil, whereas the concentration of available P increased significantly throughout the experiment. The soil pH decreased with increasing MBM doses. After the application of the highest MBM doses soil pH classification was changed from neutral to slightly acidic.
Government spending under alternative yield risk management schemes in Finland
Authors: Liesivaara Petri , Meuwissen Miranda , Myyrä Sami
Published: March 2018

The need for efficient risk management has increased in agriculture, as farmers are facing greater risks, for instance, due to climate change, price liberalisation and new plant diseases. The development of yield insurances is ongoing in many EU member countries. In Finland, the northernmost EU country, a government-financed crop damage compensation (CDC) scheme has been abolished. In this study, we analysed how the government´s expenditure would change due to the policy shift and provide insight into the tails of the loss distribution of a crop insurance scheme based on individual farm yields. According to a stochastic simulation model, the mean expenditures for the government as well as the variability in expenditure between years are expected to be lower as a result of the policy shift. The results obtained support the government’s decision to terminate the CDC scheme.
PORTRETELE COPIILOR ÎN MEDALISTICA BAROCĂ
Authors: BONŢA Claudia M.
Published: March 2018

Children Portraits in Baroque Medal Study. One of the Baroque period constancies is the image of children in the form of chubby putti, trouble makers and charming, who fill the art works of the time, regardless the genre. Religious art presents an infinite row of putti floating in frescoes and statuary groups; secular creations also fully appeal to the fresh emergence of the putti treading on air in mythological scenes, allegories, genre scenes, portraits etc. This presence records in fact also an extremely crude reality: the high infantile mortality of the period. The almost obsessive image of the small creatures mirrored the absolute consolatory faith that all those children became angels and had a special destiny. Medal work offers also a series of children portraits presenting chubby putti or individual portraits presenting the members of the Imperial family. Remarkable is the period of Maria Theresa who issued with obstinacy medals for all her children, granting attention to each of them by medals for the joy at birth, cheerful marriage announcements or in unfortunate cases, for the sadness of their premature death. The beautiful faces of Maria Theresa’s children, engraved on various medals, present a series of similar features, belonging to the series of expression portraits, having sometime remarkable plastic qualities.
Reliability of interpretation of neurologic examination findings for the localization of vestibular dysfunction in dogs
Authors: Boudreau C. Elizabeth , Dominguez Carlos E. , Levine Jonathan M. , Mankin Joseph , Anderson Kimberly M. , Voges Andra K. , Fosgate Geoffrey T.
Published: March 2018

OBJECTIVE To estimate reliability of interpretation of neurologic examination findings for localization of vestibular dysfunction in dogs.

DESIGN Cross-sectional study.

ANIMALS 496 dogs that underwent MRI of the head for diagnosis of a neurologic problem between September 2011 and September 2015.

PROCEDURES Medical records were reviewed and data collected regarding signalment and neurologic examination, MRI, and CSF findings. Independent observers interpreted the findings, and agreement was assessed for a subset of dogs. Distributions of variables were compared between dogs with and without a neurologic findings–based interpretation of vestibular disease.

RESULTS 37% (185/496) of dogs had signs of vestibular dysfunction, of which 82% (151/185) had MRI abnormalities. In 73% (110/151) of dogs with MRI abnormalities, lesions involved central vestibular structures, and in 19% (29/151), lesions involved peripheral vestibular structures. On the basis of neurologic findings interpretation, 86% (160/185) of dogs were classified as having central vestibular dysfunction, and 61% (98/160) of these had an MRI-identified central vestibular lesion. Agreement among 3 independent observers was good (κ = 0.72) regarding use of neurologic examination findings to diagnose central versus peripheral vestibular dysfunction and very good (κ = 0.85) regarding use of MRI to diagnose peripheral vestibular lesions. Despite this agreement, only 29% (7/24) of dogs with a consensus clinical interpretation of peripheral vestibular dysfunction had MRI-identified peripheral lesions.

CONCLUSIONS AND CLINICAL RELEVANCE Although interobserver agreement was good for distinguishing central from peripheral vestibular dysfunction in dogs through interpretation of neurologic examination findings, this interpretation did not agree with the MRI-based diagnosis.
Usefulness of chemotherapy for the treatment of very elderly dogs with multicentric lymphoma
Authors: Moore Antony S. , Frimberger Angela E.
Published: March 2018

OBJECTIVE To evaluate factors for associations with duration of first remission and survival time in dogs ≥ 14 years of age with stage III to V multicentric lymphoma.

DESIGN Retrospective cohort study.

ANIMALS 29 dogs ≥ 14 years of age with multicentric lymphoma treated with a chemotherapy protocol at dosages used for younger dogs (n = 22) or with prednisolone alone (7).

PROCEDURES Various data were collected from the medical records, including treatment response and related adverse events. Survival analysis was performed to determine duration of first remission and survival time (from start of chemotherapy), and these outcomes were compared between various groupings.

RESULTS The 7 (24%) dogs that received prednisolone alone had a median survival time of 27 days and were excluded from further analysis. Complete clinical remission was achieved in 21 of the 22 (95%) remaining dogs; 1 (5%) achieved partial remission. Median duration of first remission was 181 days. Anemic dogs had a briefer remission period (median, 110 days) than nonanemic dogs (median, 228 days). Median survival time for all 22 dogs was 202 days, with estimated 1- and 2-year survival rates of 31% and 5%, respectively. Six (27%) dogs had adverse events of chemotherapy classified as grade 3 or worse.

CONCLUSIONS AND CLINICAL RELEVANCE Survival time was substantially longer in dogs treated with a chemotherapy protocol versus prednisolone alone. Findings suggested that the evaluated chemotherapy protocols for lymphoma were beneficial for and tolerated by very elderly dogs, just as by younger dogs, and need not be withheld, or dosages adjusted, because of age alone.
Indications for and outcomes of limb amputation in goats and sheep
Authors: Gamsjaeger Lisa , Chigerwe Munashe
Published: March 2018

OBJECTIVE To characterize indications for and clinical outcomes of limb amputation in goats and sheep.

DESIGN Retrospective case series and observational study.

ANIMALS Goats (n = 15) and sheep (7) that underwent partial or complete limb amputation at the University of California-Davis Veterinary Medical Teaching Hospital from January 1, 1985, through December 31, 2015.

PROCEDURES Medical records of qualifying goats and sheep were reviewed and data extracted regarding signalment, use of animal, characteristics of the amputated limb, duration of hospitalization, outcome, and surgery-associated complications. The Fisher exact test was performed to compare postsurgical complication rates between various groups.

RESULTS Reasons for limb amputation included trauma (ie, fracture, dog bite, and wire-fence injury) and infectious or degenerative disease (ie, osteomyelitis and osteoarthritis). Median (range) hospitalization period for goats and sheep was 7.5 days (1 to 63 days) and 8 days (3 to 20 days), respectively. Most (7/9) of the postsurgical complications were noticed > 2 months after amputation and included uncoordinated gait, tendon breakdown and laxity of the contralateral limb, chronic lameness, surgical site infection, chronic intermittent pain, and angular limb deformity. No association was identified between postsurgical complication rate in goats and body weight category (< 20 vs ≥ 20 kg [44 lb]), age category (< 2 vs ≥ 2 years), and amputated limb type (forelimb vs hind limb).

CONCLUSIONS AND CLINICAL RELEVANCE Clinical outcomes for goats and sheep following limb amputation varied and were seemingly case dependent. Amputation should be considered when preservation of the whole limb is not possible. Veterinarians should advise owners that limb amputation may result in various complications and recommend aftercare treatment such as physiotherapy.
Pengembangan Kurikulum Bahasa Inggris Berbasis Teknologi Informasi dan Komunikasi (TIK) SD Tulangampiang, Denpasar, Bali dan Implemntasinya
Authors: Sutardi Ambari
Published: March 2018

The objective of this study is to get some information concerning English curriculum development based on ICT in Tulangampiang Primary School, Denpasar-Bali and its implementation in the classroom. The data was collected by analyzing documents, distributing questionnaire, interview students and teacher, and observing the grade V. The result shows that the teachers had already developed English curriculum in line with a manual provided by BSNP, the learning-teaching materials were taken from the learners surroundings, and be arranged with a variety of learning activities.Â ABSTRAKTujuan Â penelitian Â ini Â yaitu Â untuk Â memperoleh Â informasi Â tentang pengembangan Â kurikulum Â bahasa Inggris berbasis teknologi, informasi, dan komunikasi (TIK) sekolah dasar (SD) Tulangampiang, Denpasar-Bali dan pelaksanaannya di kelas. Data dikumpulkan dengan cara studi dokumen, kuesioner, wawancara, dan pengamatan. Hasil penelitian menunjukkan bahwa guru bahasa Inggris mengembangkan kurikulum Â sesuai Â dengan Â panduan Â dari Badan Â Standar Â Nasional Â Pendidikan Â (BSNP), Â bahan Â ajar dikembangkan dari lingkungan peserta didik yang disusun dengan berbagai kegiatan pembelajaran.
Doğu Anadolu Bölgesinde Gıda Olarak Kullanılan Yabani Bitkiler
Authors: Okcu Zühal , Kaplan Benay
Published: March 2018

Several herb can grow naturally thanks to climate and geographical features of Turkey. Although there are approximately one million weed in the world, there are still many unidentified weeds. While more than ten thousand weeds are used as a food, only 3000 weeds species are cultivated in Turkey. Eastern Anatolia region is one of the most important regions of Turkey in terms of consuming weeds. The rate of endemic plants is higher in this region, most of them are important economically, because they can be used as a medicinal plants, spices, ornaments, dyes or food. Not only these are utilized as raw or cooked food but also flavorant.
Pazarsuyu Deresi (Giresun, Türkiye) Sediment Kalitesinin Çok Değişkenli İstatistik Yöntemlerle Belirlenmesi
Authors: Ustaoğlu Fikret , Tepe Yalçın
Published: March 2018

The present study, aimed to determine sediment quality of Pazarsuyu Stream, located in the city limit Giresun, Black Sea Region, were carried out between June 2014 and May 2015. The average heavy metal levels of samples taken seasonally from four selected stations were as follow; Cr; 10.64 ppm, Mn; 155.83 ppm, Fe; 8312 ppm, Co; 5.73 ppm, Cu; 17.79 ppm, Zn; 32.74 ppm, Cd; 0.16 ppm, Pb; 19.69 ppm. Additionally, the average sediment organic matter % and pH were found as 6.64 and 5.02, respectively. The obtained data were evaluated statistically by one way ANOVA, Pearson correlation analysis, cluster, and factor analysis. Dot graphs were made by using PAST statistical program. The level of heavy metal pollution in the stream sediment were determined by comparisons of our graphs with sediment quality criteria and the mean heavy metal concentrations of the earth.
A preliminary study of fecundity of whiting, Merlangius merlangus euxinus (Linnaeus, 1758) in coast of Tirebolu (Eastern Black Sea)
Authors: Taylan Burcu , Gurkan Sule , Taskavak Ertan , Aydın Uncumusaoglu Arzu
Published: March 2018

In this research, a preliminary study was carried out in January and February 2014 to determine the fecundity of the whiting species in Tirebolu, Eastern Black Sea. After the total length (cm) and weight (0.01 g) of the 70 fish specimens were measured in the laboratory, they were dissected for sex determination. Using the 20 ovaries at the third and fourth maturation stages, 3 sub-samples which is 2-5% of the total ovary weight (from the anterior, median and posterior parts of the ovary) were taken from each ovary to determine the fecundity, and hydrated oocytes were counted with gravimetric method. Total fecundity, total oocytes number in the ovary were computed with the formula F=(n×G)/g. The total length-weight values were 12.6-23.3 cm (mean 17.08±2.12) and 15.59-95.72 g (mean 41.07 ± 16.75), respectively, and total length-weight relationship was computed as W=0.0073L3.024 (R2=0.94) for the 70 fishes evaluated. Fecundity was computed as 3.247-30.534 (mean: 10.139±6.953) eggs and a linear relationship between fecundity and total length was calculated as F=0.0186L4.5631 (R2=0.70). In conclusion, the fecundity results of this prelaminar study were compared with similar studies on the whiting species from Black Sea and other seas.
Polifenol Oksidaz Enzimi ve İnaktivasyon Yöntemleri
Authors: Yılmaz Leman , Elmacı Yeşim
Published: March 2018

Polyphenol oxidase enzyme is found in vegetables and fruits, as well as in some animal organs and microorganisms. Polyphenol oxidase enzyme responsible for enzymatic browning is a group of copper proteins that catalyses the oxidation of phenolic compounds to quinones, which produce brown pigments, commonly found in fruits and vegetables. During the industrial preparation of fruits and vegetables, results of catalytic effect of polyphenol oxidase causes enzymatic browning. Enzymatic browning impairs the appearance of products containing phenolic compounds along with undesirable colour, odor and taste formation and significant loss of nutritional value of the products. This affects the acceptability of the products by the consumers and causes economic losses. In this review, some characteristics of polyphenol oxidase enzyme in different fruits and vegetables have been reviewed and information about chemical antibrowning agents, thermal applications, irradiation applications and alternative methods such as high pressure processing, pulse electric field, supercritical carbon dioxide and ultrasound applications to inactivate this enzyme has been presented.
Hatay İli Yonca Üretim Alanlarında Bulunan Böcek Faunasının Tespiti ve Bazı Türlerin Popülasyon Yoğunlukları
Authors: Kaya Kamuran
Published: March 2018

The current study was conducted to determine insect fauna and population densities of some phytophagous and beneficial insect species at two different alfalfa fields in Narlıca district of Hatay province, Turkey in 2009-2010. In the first year biweekly, and in the second year weekly samplings were carried out by 25 sweep-net samplings taken by walking in diagonal directions. Aphids, thrips and gallery flies were also sampled by counting of 30 alfalfa stalks in every 8-10 steps in each of the sampling fields. As a result, 53 phytophagous species belonging to 14 families of five orders and 30 natural enemy species including 20 predators and 10 parasitoids belonging to nine families of six orders were obtained. With 19 species, Cicadellidae has been the largest number of species-containing family and Asymmetrasca descedens and Empoasca decipiens were the most intensively species in this family. In addition, Lygus rugulipennis was the most dominant species among all phytophagous species obtained. It has been found that populations of all pests species were affected by mowing the alfalfa, and show a decline. Predators were predominant among detected natural enemies, and their populations were persistent in the alfalfa fields despite approximately 7-8 mowing per year.
Endüstriyel Sızıntı Suyundan Pb(II) Giderimi İçin Genleştirilmiş Perlit Kullanımı: Kinetik Çalışmalar
Authors: Aydın Temel Fulya
Published: March 2018

In this study, the removal efficiency of Pb(II) from industrial leachate was investigated by using expanded perlite by adsorption. The effects of pH, contact time, and adsorbent dosage were examined on the Pb(II) removal. The adsorption kinetics were tested to understand the adsorption mechanism using three kinetic models, i.e., Elovich, intraparticle diffusion, and the pseudo second order reaction kinetic models. As the result, the best conformity kinetic model for Pb(II) adsorption on expanded perlite was described as the pseudo second-order (R2>0.99). It is indicated that chemisorption is the determining step of adsorption process rather than mass transfer from industrial leachate. According to the data obtained from intraparticle diffusion model, the adsorption is composed of more than one step. This can be attributed to the fact that the adsorption in the final portion was the intraparticle diffusion while the adsorption in the first portion was the film diffusion. Both film diffusion and intraparticle diffusion processes in the adsorption of Pb(II) on expanded perlite are significant. This study indicated that expanded perlite was an influential alternative adsorbent for the removal of Pb(II) by adsorption from industrial leachate.
PENGARUH EFEKTIVITAS DEWAN KOMISARIS DAN KOMITE AUDIT, STRUKTUR KEPEMILIKAN, DAN KUALITAS AUDIT TERHADAP MANAJEMEN LABA
Authors: Lestari Eka , Murtanto Murtanto
Published: March 2018

The purpose of this study was to examine, analyze, and find empirical evidence of the influence the effectiveness of the board of commissioners and audit committee, concentrated ownership, managerial ownership, institutional ownership, and audit quality on earnings management with company size, company performance, and leverage as variable controls. The sample used in this study was 42 companies listed on the Indonesia Stock Exchange (IDX) in period 2013-2015. The sampling technique used was purposive sampling. This study used multiple regression analysis. The results of this study show that effectiveness of the board of commissioners, concentrated ownership, managerial ownership have negative effect on earnings management. However, the effectiveness of audit committees, institutional ownership, and audit quality doesn’t have effect on earnings management. As well, the firm size, firm performance, and leverage have effect on earnings management.
mmpdb: An Open Source Matched Molecular Pair Platform for Large Multi-Property Datasets
Authors: Dalke Andrew , Hert Jerome , Kramer Christian
Published: March 2018

We present mmpdb, an open source Matched Molecular Pair (MMP) platform to create, compile, store, retrieve, and use MMP rules. mmpdb is suitable for the large datasets typically found in pharmaceutical and agrochemical companies and provides new algorithms for fragment canonicalization and stereochemistry handling. The platform is written in Python and based on the RDKit toolkit. mmpdb is freely available.
Open source software tools for computer aided drug design
Authors: Kanwar Gurtej , Kumar Anish , Mahajan Anshika
Published: March 2018

Computer-aided drug design (CADD) has revolutionized the drug discovery arena and it has reduced the costs associated with finding novel compounds which are having pharmaceutical importance. In CADD, the scientists use the computer software to discover biological active compounds. Molecular docking and energy minimization tools are essential components of structure based drug design. It is a significant tool in structural molecular biology and computer-assisted drug design. It reduces the laboratory workload of the end user and allows researchers to restrict their docking studies to the smallest and the most representative set of macromolecules and small molecules possible. This greatly enhances the productivity of researchers. Energy minimization is an important criterion for selecting a potential 3D molecule. In modeled structures, the 3D structure is affected is due to steric clashes. These clashes happen in a protein structure due to the overlap of non bonding atoms and with the assistance of energy minimization, steric clashes can be eradicated. The open software’s and databases provides a platform for scientists and scholars to carry out their research work in a better way. The docking tools are discussed in this review cover protein-ligand, protein-peptide as well as protein-nucleic acid docking. The tools described include AutoDock 4 and Vina, UCSF DOCK, FLIPDock, EADock, HADDOCK 2.2, SwissDock, PatchDock and ClusPro. In addition to the docking tools, energy minimization tools such as YASARA minimization server, KoBaMIN server and 3D refine server have also been discussed. This mini-review concentrates on open software tools which are free of cost and can be easily downloaded in the computers that are useful for CADD.

Keywords: Molecular docking; Energy minimization; Structure refinement; Drug design; CADD
Antioxidant capacity of hydroalcoholic extracts of Grewia serrulata DC and Grewia nervosa (Lour.) Panigrahi
Authors: Ramesh Mentham , Rao Chandu Babu
Published: March 2018

The current investigation is intended to evaluate the content of phytochemical constituents and antioxidant potential of hydroalcoholic extracts of stem and root of Grewia serrulata DC (HAESGS & HAERGS) and leaf and bark of Grewia Nervosa (Lour.) panigrahi (HAELGN & HAEBGN). Initially, all the extracts at different concentrations were estimated for their total phenolic content and total flavonoid content. The study was further extended for their antioxidant potential evaluation using various in vitro methods such as 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical, hydroxyl radical and superoxide radical scavenging assays. The total phenolic content (mg gallic acid equivalent per gram of extract) was high in HAELGN (170.82±0.19) and HAERGS (123.00±0.48) than HAESGS (111.2±0.26) and HAEBGN (119.60±0.23). The total flavonoid content (mg quercetin equivalent per gram) is greater in HAERGS (71.24±0.50) and HAESGS (65.68±0.27) than HAELGN (55.82±0.35) and HAEBGN (62.38±0.45). The IC50 values (µg/ml) of different plant extracts inferred that DPPH radical scavenging activity is greater in HAELGN (42.91±0.88) and HAEBGN (53.87±0.35) than HAESGS (126.73±1.20) and HAERGS (88.87±1.25). However, hydroxyl and superoxide radical scavenging activity is more in HAERGS (135.41±1.19 & 88.00±1.42) and HAELGN (172.28±1.91 & 108.163±1.09) than HAESGS (237.3±1.65 & 110.074±0.87) and HAEBGN (204.7±1.04 & 125.54±1.07). The results of present comprehensive analysis demonstrated that both the plants Grewia serrulata DC and Grewia Nervosa (Lour.) panigrahi possess high phenolic, flavonoid contents and potential antioxidant activity, and could be used as a valid source of natural antioxidants and might be utilized for pharmacological screening of various therapeutic activities.

Keywords: Grewia serrulata; Grewia Nervosa; Total Phenolic content; Total flavonoid content; Antioxidant potential