bluuebunny/crossref_metadata_2025 huggingface dataset:
Emergency Surgical Airway in Life-Threatening Acute Airway Emergencies – Why are We So Reluctant to Do It?
Authors: Greenland K. B. , Acott C. , Segal R. , Goulding G. , Riley R. H. , Merry A. F.
Published: January 2019

‘Can't intubate, can't oxygenate’ scenarios are rare but are often poorly managed, with potentially disastrous consequences. In our opinion, all doctors should be able to create a surgical airway if necessary. More practically, at least all anaesthetists should have this ability. There should be a change in culture to one that encourages and facilitates the performance of a life-saving emergency surgical airway when required. In this regard, an understanding of the human factors that influence the decision to perform an emergency surgical airway is as important as technical skill. Standardisation of difficult airway equipment in areas where anaesthesia is performed is a step toward ensuring that an emergency surgical airway will be performed appropriately. Information on the incidence and clinical management of ‘can't intubate, can't oxygenate’ scenarios should be compiled through various sources, including national coronial inquest databases and anaesthetic critical incident reporting systems. A systematic approach to teaching and maintaining human factors in airway crisis management and emergency surgical airway skills to anaesthetic trainees and specialists should be developed: in our opinion participation should be mandatory. Importantly, the view that performing an emergency surgical airway is an admission of anaesthetist failure should be strongly countered.
Effect of Epidural Levobupivacaine on Recovery from Vecuronium-Induced Neuromuscular Block in Patients Undergoing Lower Abdominal Surgery
Authors: Şahin S. H. , Çolak A. , Sezer A. , Arar C. , Sevdi S. , Gunday I. , Sut N.
Published: January 2019

The aim of this study was to evaluate the effect of epidural levobupivacaine on recovery from vecuronium-induced neuromuscular block. Ninety patients undergoing lower abdominal surgery were randomised into two groups after an epidural test dose: the epidural group (n=45) received a bolus of 15 ml of 0.5% levobupivacaine whereas the control group (n=45) did not. Anaesthesia was induced and maintained with propofol, fentanyl, vecuronium and nitrous oxide. Neuromuscular block was induced with vecuronium 0.1 mg/kg and monitored with acceleromyographic train-of-four at the adductor pollicis. Patients in each group received neostigmine at 25% recovery of the first twitch of train-of-four during recovery from anaesthesia. The effect of epidural levobupivacaine on the speed of recovery of neuromuscular function was evaluated. The lag time, onset time and time from vecuronium administration until 25% T1 recovery did not differ between the groups. The times of the recovery index (the time from 25% to 75% recovery of T1) and of the DUR 25-train-of-four 90 (time from 25% T1 to train-of-four ratio of 0.9) in the epidural group were significantly longer than those for the control group (5.2 [2.1] vs 3.04 [1.02] minutes and 10.8 [3.3] vs 8.2 [2.3] minutes, P <0.001). This study shows that epidural levobupivacaine significantly delays the train-of-four recovery from vecuronium-induced block. Although the interaction is small in the clinical setting, anaesthetists should take this interaction into consideration when combining general and epidural anaesthesia during surgery.
Clinical Prediction of Weaning and Extubation in Australian and New Zealand Intensive Care Units
Authors: Rose L. , Presneill J. J.
Published: January 2019

Our objective was to describe, in Australian and New Zealand adult intensive care units, the relative frequency in which various clinical criteria were used to predict weaning and extubation, and the weaning methods employed.

Participant intensivists at 55 intensive care units completed a self-administered questionnaire, using visual analogue scales (0=not at all predictive, 10=perfectly predictive, not used=null score) to record the perceived utility of 30 potential predictors.

Survey response rate was 71% (164/230). Those variables thought most predictive of weaning readiness were respiratory rate (median score 8.0, interquartile range 7.0 to 8.6) effective cough (7.3, 5.9 to 8.2) and pressure support setting (7.2, 6.0 to 8.0). The most highly rated predictors of extubation success were effective cough (8.0, 7.0 to 9.0), respiratory rate (8.0, 7.0 to 8.5) and Glasgow Coma Score (7.9, 6.1 to 8.3). Variables perceived least predictive of weaning and extubation success were P0.1, Acute Physiological and Chronic Health Evaluation score II, mean arterial pressure, electrolytes and maximum inspiratory pressure (individual median scores <5). Most popular clinical criteria were those perceived to have high predictive accuracy, both for weaning (respiratory rate 96%, pressure support setting 94% and Glasgow coma score 91%) and extubation readiness (respiratory rate 98%, effective cough 94% and Glasgow Coma Score 92%). Weaning mostly employed pressure support ventilation (55%), with less use of synchronised intermittent mandatory ventilation (32%) and spontaneous breathing trials (13%).

Classic ventilatory performance predictors including respiratory rate and effective cough were reported to be of greater clinical utility than other more recently proposed measures.
Failure to Ventilate with Supraglottic Airways after Drowning
Authors: Baker P. A. , Webber J. B.
Published: January 2019

We report the failure of an i-gel® and an Ambu® AuraOnce™ supraglottic airway to ventilate a drowning victim. Failure was attributed to changes in lung physiology following submersion and inhalation of water that may have required ventilation pressures up to 40 cmH2O to treat the victim's hypoxaemia. The ease of use and rapid insertion of supraglottic airways without interrupting cardiac compression has prompted recommendations for their use during resuscitation. The relatively low leak pressures attainable from many supraglottic airways, however, may cause inadequate lung ventilation and entrainment of air into the stomach when these devices are used in drowning victims.
Ten Commandments of Interpreting and Applying Results of Biomarker Research
Authors: Ho K. M.
Published: January 2019

Prognostic and diagnostic capabilities of a biomarker are ‘two sides of the same coin’ in medicine. For instance, serum troponin is very useful in diagnosing acute myocardial infarction and, at the same time, the peak concentrations of serum troponin are also useful in assessing the prognosis of both ST-elevation myocardial infarction (STEMI) and non-STEMI1. In this issue of the Journal, we have two interesting studies on prognostic significance of serum C-reactive protein (CRP) or lactate concentrations in critically ill patients2,3, and they conclude that these non-specific biomarkers may be useful to predict mortality of critically ill patients.
Markers of Coagulation Activation after Hepatic Resection for Cancer: Evidence of Sustained Upregulation of Coagulation
Authors: Weinberg L. , Scurrah N. , Parker F. C. , Dauer R. , Marshall J. , Mccall P. , Story D. , Smith C. , Mcnicol L.
Published: January 2019

We investigated the possibility that despite postoperative derangements of routine laboratory coagulation tests, markers of coagulation activation and thrombin generation would be normal or increased in patients undergoing hepatic resection for cancer. In addition to the conventional coagulation tests prothrombin time and activated partial thromboplastin time, we measured select markers of coagulation activation prothrombin fragments 1 and 2 (PF1+2), thrombin-antithrombin complexes and plasma von Willebrand Factor antigen in 21 patients undergoing hepatic resection. The impact of hepatic resection on coagulation and fibrinolysis was studied with thromboelastography. Preoperatively, routine laboratory coagulation and liver function tests were normal in all patients. On the first postoperative day, prothrombin time was prolonged (range 16 to 22 seconds) in eight patients (38%). For these patients, thromboelastography was normal in six (75%), PF1+2 was elevated in four (50%), and thrombin-antithrombin complexes and von Willebrand Factor antigen were elevated in all, which was evidence of acute phase reaction, sustained coagulation factor turnover and activation. By the fifth postoperative day, despite normalisation of prothrombin time, markers of increased coagulation activity remained greater than 85% of baseline values. The findings indicate that in patients undergoing liver resection for cancer, there is significant and prolonged postoperative activation of the haemostatic system despite routine coagulation tests being normal or even prolonged. Before considering therapeutic interventions an integrated approach to interpreting haematological data with clinical correlation is essential.
Safety of Exposure of Malignant Hyperthermia Non-Susceptible Patients and Their Relatives to Anaesthetic Triggering Agents
Authors: Pollock N. , Langton E. E. , Stowell K. M. , Bulger T. F.
Published: January 2019

As the reliability of malignant hyperthermia normal in vitro contracture test results has been questioned, this study set out to determine the reliability of malignant hyperthermia normal results in New Zealand. Three hundred and twenty-nine anaesthetics were administered to malignant hyperthermia normal patients, identified through the Palmerston North Hospital malignant hyperthermia database. Anaesthetic records were retrieved and scrutinised for a malignant hyperthermia reaction using the Malignant Hyperthermia Clinical Grading Scale. Patients were exposed to one or more of eight triggering agents and multiple anaesthetic agents were administered in 41% of cases. Six variables were analysed, and although a minority of variables were abnormal in a small number of patients, none of the findings supported a malignant hyperthermia reaction. While the analysis was limited by the adequacy of the anaesthesia records, it was supported by negative DNA analysis in 55% of patients. This study supports several previous studies in demonstrating that patients in New Zealand tested non-susceptible to malignant hyperthermia can safely be given triggering agents.
The Impact of Anaesthetic Trainees on Elective Caesarean Section Procedural Times: A Prospective Observational Study
Authors: Browne W. , Siu L. W. L. , Monagle J. P.
Published: January 2019

Operating room efficiency is an important concern in hospitals today both in the public and private sectors. Currently, a paucity of literature exists to evaluate the impact of anaesthetic training on operating room efficiency in the Australian health system. At Monash Medical Centre, Clayton, private consultant operating sessions and public teaching operating sessions use the same operating theatres, nursing and technical staff. Consultant anaesthetists and obstetricians perform all tasks during private sessions, whereas anaesthetic and obstetric trainees perform many tasks during public sessions. In this prospective observational study, total case time, anaesthesia controlled time and the surgical time were measured for elective caesarean section under spinal anaesthesia in 59 patients (private consultantn=29, public teaching n=30). Increases in total case time (24 minutes, P <0.001), anaesthesia controlled time (5.2 minutes, P <0.015) and surgical time (19.25 minutes, P <0.001) were observed in the public teaching group compared with the private consultant group. The participation of anesthetic trainees in caesarean sections results in a modest increase in anaesthetic controlled time of approximately five minutes per case or 16 minutes in an operative session with three cases scheduled. Elimination of anaesthetic ‘training’ time does not allow scheduling of an extra elective caesarean section. Reduced operating theatre throughput is unlikely to be a consequence of training specialist anaesthetists in this clinical setting.
The History of Premedication
Authors: Ball C. , Westhorpe R. N.
Published: January 2019

“- An anaesthetic is a frightening adventure into the unknown over which a patient can exert no control, and few can meet this type of ordeal with equanimity”1. British Medical Journal, 1964.

Prior to the discovery of anaesthesia, medication before surgery was the only way of diminishing the patient's suffering. In 1682, George Wedel, Professor of Medicine at Jena, suggested that opium could be given to a patient prior to an amputation so that he “… bears the burning and cutting of the limb with a readier spirit”2. Alcohol was often recommended for the same reason3. In 1805, Seishu Hanaoka, a Japanese surgeon, administered a potent oral mixture of alkaloids, largely from the Datura stramonium plant, to a woman for a mastectomy4. He called this mixture Tsusensan, successfully using it on many patients: it produced hours of complete unconsciousness – long before Morton demonstrated the effect of ether.
Hydrogen Peroxide – A Party Trick from the Past?
Authors: Reid C. J. , Alcock M. , Penn D.
Published: January 2019

Hydrogen peroxide solutions are found in almost every operating theatre and are used by many surgical specialties, often with little knowledge of their inherent risk. We reviewed the literature and evidence related to the use of hydrogen peroxide in surgery. We found little evidence supporting the use of hydrogen peroxide solutions intraoperatively, a large number of reports of sometimes-fatal oxygen embolism and other evidence of tissue toxicity. We conclude that the use of hydrogen peroxide as an antiseptic has no direct benefit, but is associated with significant risk, and therefore should be reconsidered.
Laryngeal Mask Airway for Airway Control during Percutaneous Dilatational Tracheostomy
Authors: Pratt T. , Bromilow J.
Published: January 2019

Percutaneous dilatational tracheostomy is a common bedside procedure in critical care for patients requiring prolonged mechanical ventilation. The traditional technique requires withdrawal of the endotracheal tube to a proximal position to facilitate tracheostomy insertion, but this carries the risk of inadvertent extubation and does not prevent cuff rupture. Use of a supraglottic airway such as the laryngeal mask airway may avoid these risks and could provide a safe alternative to the endotracheal tube. We present an appraisal of the literature to date. We found reasonable evidence to show improved ventilation and bronchoscopic visualisation with the laryngeal mask airway, but this has not been translated into improved outcome. There is currently insufficient evidence to draw conclusions about the safety of the laryngeal mask airway during percutaneous dilatational tracheostomy.
An Anatomical Study of the Intradural Space
Authors: Collier C. B. , Reina M. A. , Prats-Galino A. , Machés F.
Published: January 2019

We have previously postulated that it is possible to accidentally insert an epidural needle or catheter into the substance of the dura during attempted epidural block, creating an intradural space. It appears that injection of local anaesthetic into an intradural space leads to an initially inadequate neuraxial block but further doses may produce an extensive life-threatening block. In the laboratory, 54 samples of human thoraco-lumbar dura were obtained from six cadavers and prepared for scanning electron microscopy. Images from these dehydrated specimens were assessed for the presence of spaces within the dura, and attempts were made to insert an epidural catheter, under optical microscopy, into the substance of the dura in 32 cases. Electron microscopy revealed the concentric laminae that compose the dura and the presence of artefactual spaces between some of these. It was possible to insert an epidural catheter into the substance of the dura in eight specimens, creating intradural spaces which remained following catheter removal. If this represents the clinical situation, it may help to explain previously reported cases of atypical neuraxial block and their associated radiological findings.
A Comparison of the Forces Applied to a Manikin during Laryngoscopy with the Glidescope® and Macintosh Laryngoscopes
Authors: Russell T. , Lee C. , Firat M. , Cooper R. M.
Published: January 2019

The force applied during laryngoscopy can cause local tissue trauma and can induce cardiovascular responses and cervical spine movement in susceptible patients. Previous studies have identified numerous operator and patient factors that influence the amount of force applied during intubation. There are few studies evaluating the effect of different laryngoscope blades and no study involving video laryngoscopes. In this study we measured the forces using two laryngoscopic techniques. Three FlexiForce Sensors® (A201-25, Tekscan, Boston, MA, USA) were attached to the concave blade surface of a Macintosh and a GlideScope® laryngoscope. Experienced anaesthetists performed Macintosh and GlideScope intubations on the Laerdal® Airway Management Trainer manikin. Compared to Macintosh intubations, the GlideScope intubations had equal or superior views of the glottis with 55%, 58% and 66% lower median peak, average and impulse forces applied to the tongue base. The distal sensor registered the most force in both devices and the force distribution pattern was similar between the devices. The findings suggest that the GlideScope requires less force for similar or better laryngoscopic views, at least in a manikin model.
Incidence, Risk Factors and Outcome Associations of Intra-Abdominal Hypertension in Critically Ill Patients
Authors: Kim I. B. , Prowle J. , Baldwin I. , Bellomo R.
Published: January 2019

Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are significantly associated with morbidity and mortality. We performed a prospective observational study and applied recently published consensus criteria to measure and describe the incidence of IAH and ACS, identify risk factors for their development and define their association with outcomes. We studied 100 consecutive patients admitted to our general intensive care unit. We recorded relevant demographic, clinical data and maximal (max) and mean intra-abdominal pressure (IAP). We measured and defined IAH and ACS using consensus guidelines. Of our study patients, 42% (by IAPmax) and 38% (by IAPmean) had IAH. Patients with IAH had greater mean body mass index (30.4±9.6 vs 25.4±5.6 kg/m2, P=0.005), Acute Physiology and Chronic Health Evaluation III score (78.2±28.5 vs 65.5±29.2, P=0.03) and central venous pressure (12.8±4.8 vs 9.2±3.5 mmHg, P <0.001), lower abdominal perfusion pressure (67.6±13.5 vs 79.3±17.3 mmHg, P <0.001) and lower filtration gradient (51.2±14.8 vs 71.6±17.7 mmHg; P <0.001). Risk factors associated with IAH were body mass index ≥30 (P <0.001), higher central venous pressure (P <0.001), presence of abdominal infection (P=0.005) and presence of sepsis on admission (P=0.035). Abdominal compartment syndrome developed in 4% of patients. IAP was not associated with an increased risk of mortality after adjusting for other confounders. We conclude that, in a general population of critically ill patients, using consensus guidelines, IAH was common and significantly associated with obesity and sepsis on admission. In a minority of patients, IAH was associated with abdominal compartment syndrome. In this cohort IAH was not associated with an increased risk of mortality.
L-Arginine Cardioplegia Reduces Oxidative Stress and Preserves Diastolic Function in Patients with Low Ejection Fraction Undergoing Coronary Artery Surgery
Authors: Andrews D. T. , Sutherland J. , Dawson P. , Royse A. G. , Royse C. F.
Published: January 2019

L-arginine cardioplegia decreases biochemical markers of myocardial damage and oxidative stress in patients with normal left ventricular function. We investigated the effects of L-arginine supplemented cardioplegic arrest in patients with reduced ejection fraction. Fifty-three adult patients with left ventricular ejection fraction <35% undergoing elective coronary artery bypass surgery were randomised to receive blood cardioplegia with or without L-arginine. Following cardiopulmonary bypass, measured endpoints were cardiac troponin-I concentration at 12 and 24 hours, coronary sinus concentrations of malondialdehyde and superoxide dismutase activity at five and 15 minutes, lactic acid flux at one, five and 15 minutes and left ventricular systolic and diastolic function after protamine administration. There were no differences in cardiac troponin-I between groups. Malondialdehyde was lower in L-arginine group, 0.28±0.12 vs 0.48±0.32 (5 minutes) and 0.31±0.14 vs 0.38±0.15 nmol.ml−1 (15 minutes) (P=0.0004). Superoxide dismutase activity was higher in L-arginine group, 229±87 vs 191.3±68 (5 minutes), 229±54 vs 198±15 nmol.minute−1.ml (15 minutes) (P=0.005). Lactic acid flux was lower in the L-arginine group, 0.15±0.23 vs 0.48±0.32 (1 minute), 0.08±0.19 vs 0.38±0.31 (5 minutes) and −0.15±0.13 vs 0.26±0.30 mmol.l−1 (15 minutes), (P=0.0003). There was no difference in left ventricular systolic function. The mitral annular tissue Doppler inflow (eʹ) velocity during early diastole improved in the L-arginine group following cardiopulmonary bypass (control 4.2±1.9 cm.s−1 to 3.6±1.2 cm.s−1 vs L-arginine 3.8±1.2 cm.s−1 to 4.6±1.4 cm.s−1) (P=0.018). In patients with reduced ejection fraction, L-arginine supplemented cardioplegic arrest did not affect postoperative cardiac troponin-I levels, but attenuated cardiac cellular peroxidation and improved early left ventricular diastolic function.
A Useful New Coma Scale in Acute Stroke Patients: Four Score
Authors: Kocak Y. , Ozturk S. , Ege F. , Ekmekci A. H.
Published: January 2019

Assessment of the severity of unconsciousness in patients with impaired consciousness, prediction of mortality and prognosis are currently the most studied subjects in intensive care. The aim of this study was to investigate the usefulness of the Full Outline of UnResponsiveness (FOUR) score in intensive care unit patients with stroke and the associations of FOUR score with the clinical outcome and with other coma scales (Glasgow [GCS] and Acute Physiology and Chronic Health Evaluation II). One hundred acute stroke patients (44 male, 56 female), who were followed in a neurology intensive care unit, were included in this prospective study. The mean age of the patients was 70.49±12.42 years. Lesion types were determined as haemorrhagic in 30 and ischaemic in 70 patients. FOUR scores on the day of admission and the first, third and 10th days of patients who died within 15 days were lower when compared to scores of patients who survived (P=0.005, P=0.000, P=0.000 and P=0.000 respectively). Receiver operating characteristic curve analysis showed significant trending with both FOUR score and GCS for prognosis; the area under curve ranged from 0.675 (95% confidence interval 0.565 to 0.786) when measurements had been made on day 3 to 0.922 (95% confidence interval 0.867 to 0.977) and 0.981 (95% confidence interval 0.947 to 1.015) for day 10. We suggest that FOUR score is a useful scale for evaluation of acute stroke patients in the intensive care unit as a homogeneous group, with respect to the outcome estimation.
Evaluation of the Mediseus® Epidural Simulator
Authors: Lee R. A. , van Zundert T. C. R. V. , van Koesveld J. J. M. , van Zundert A. A. J. , Stolker R.-J. , Wieringa P. A. , Gatt S. P.
Published: January 2019

The demand for increased patient safety has led to greater use of simulation training of health professionals performing medical procedures. The study aim was to evaluate the usefulness of the Mediseus® Epidural Simulator in teaching basic epidural needle-handling skills.

Three groups of 15 anaesthetists (Novice=zero to two year anaesthesia trainees; Intermediate=three- to five-year anaesthesia trainees; Expert=consultants and regional-specialist anaesthetists) from three different medical centres participated. Each participant performed 20 simulated epidural needle insertions and was scored on several parameters (e.g. time, success of the insertion, bone collisions). Following familiarisation with the simulator and the needle insertions, participants answered seven questions on the applicability of the simulator to the teaching of basic epidural needle-handling skills.

There was a clear learning effect with regard to the simulation procedure time, this decreasing throughout the experiment (P=0.037). There was no significant influence of either group or experience with the simulator in the study on the number or type of errors made. The quality of the simulation was scored 2.3 out of 5.0 (for bone simulation) and 4.7 (for loss-of-resistance simulation). All groups considered that the simulator was best suited for training prospective anaesthetists. Each group rated the usefulness of the simulator for training novices at greater than 3.0 out of 5.0.

The Mediseus® Epidural Simulator seems to be an appropriate training device for an introduction to epidural needle insertion. For medical professionals with procedural knowledge, the simulation is not realistic enough and the simulator did not distinguish between the groups based on the errors made.
Predictive Performance of Acute Physiological and Chronic Health Evaluation Releases II to IV: A Single New Zealand Centre Experience
Authors: Mann S. L. , Marshall M. R. , Woodford B. J. , Holt A. , Williams A. B.
Published: January 2019

There is debate in Australia and New Zealand around the appropriate use of illness severity scoring systems in Australasian intensive care units. The international benchmark is the Acute Physiological and Chronic Health Evaluation (APACHE) system. In order to compare the performance of recent APACHE releases, we audited 2080 sequential patients admitted between 1 January 2006 and 31 March 2008 to the Middlemore Hospital intensive care unit in Auckland, New Zealand. We compared the predictive performance of the proprietary APACHE II, IIIh, IIIj and IV releases, and the performance of a ‘localised’ version of APACHE II containing re-estimated coefficients derived from a legacy dataset (7703 sequential patients admitted between 1 January 1997 and 31 December 2005). Discrimination assessed by receiver operating characteristic curves was highest with the APACHE III and IV releases, and significantly better than the APACHE II releases. Calibration assessed by the Hosmer-Lemeshow statistic was poor with all releases, although it was best with APACHE IV and ‘localised’ version of the APACHE II release. Overall accuracy assessed by the Brier Mean Probability score and Shapiro's R statistic was best with APACHE IV. Our study suggests the possibility of improved prediction in moving to APACHE IV from older releases, although broader multicentre study within the Australian and New Zealand critical care community is warranted. Our study also suggests that localisation of the APACHE system offers further opportunity to improve prediction, although these improvements may not be major without ground-up development of a new risk prediction model within our local critical care setting.
Intensive Care Unit Admission in Patients following Rapid Response Team Activation: Call Factors, Patient Characteristics and Hospital Outcomes
Authors: Le Guen M. P. , Tobin A. E. , Reid D.
Published: January 2019

Rapid Response Systems (RRSs) have been widely introduced throughout hospital health systems, yet there is limited research on the characteristics and outcomes of patients admitted to an intensive care unit (ICU) following RRS activation. Using database extraction, this study examined the factors associated with ICU admission and patient outcome in patients receiving RRS activation in a tertiary level hospital between 2009 and 2013. Of 3004 RRS activations, 392 resulted in ICU admissions. Call factors associated with ICU admission and increased hospital mortality included tachypnoea ( P <0.001 and P <0.001, respectively), hypoxia ( P <0.001 and P <0.001, respectively) and having multiple Medical Emergency Team call triggers breached simultaneously ( P <0.001 and P <0.001, respectively). Patients with seizures ( P <0.001) and tachycardia ( P=0.004) were more likely to survive to hospital discharge. Patient factors associated with ICU admission included young age ( P <0.001) and having severe liver disease ( P <0.001). Factors associated with increased hospital mortality included delayed RRS activation ( P <0.001), increased age ( P <0.001) and comorbidities including ischaemic heart disease ( P=0.006), congestive heart failure ( P <0.001), chronic kidney disease ( P <0.001) and severe liver disease ( P <0.001). Multiple factors relating to both the nature of the RRS activation call and patient characteristics are associated with ICU admission and hospital mortality post RRS activation. This information may be useful for risk stratification of deteriorating patients and determination of appropriate escalation.
Review of Critical Incidents in a University Department of Anaesthesia
Authors: Saito T. , Wong Z. W. , Thinn K. K. , Poon K. H. , Liu E.
Published: January 2019

In 2011, our hospital started a new system of 100% procedural audit of anaesthesia work, in which we incorporated the reporting of critical incidents. This monitoring of critical incidents has enabled identification of the spectrum of incidents and risk factors and helped in the education of trainees and specialists. In this review, we analyse 379 incidents that had been reported among 44,915 anaesthetics administered in a two-year period. The risk of incidents was higher in patients of lower American Society of Anesthesiologists physical status, anaesthesia of long duration and anaesthesia carried out after-hours. The most common incidents were airway problems and drug administration problems. Fifty-nine percent of incidents were evaluated to be preventable and adverse outcomes occurred in 48% of cases. Human factors were the major contributors to incidents. We suggest that incorporating critical incident reporting as part of a 100% procedural audit facilitated, rather than discouraged, the reporting of critical incidents, even though reporting was not anonymous. The rate of incident reporting increased from 0.37% to 0.84%.
Pitfalls in Haemodynamic Monitoring in the Postoperative and Critical Care Setting
Authors: Ho K. M.
Published: January 2019

Haemodynamic monitoring is a vital part of daily practice in anaesthesia and intensive care. Although there is evidence to suggest that goal-directed therapy may improve outcomes in the perioperative period, which haemodynamic targets we should aim at to optimise patient outcomes remain elusive and controversial. This review highlights the pitfalls in commonly used haemodynamic targets, including arterial blood pressure, central venous pressure, cardiac output, central venous oxygen saturation and dynamic haemodynamic indices. Evidence suggests that autoregulation in regional organ circulation may change either due to chronic hypertension or different disease processes such as traumatic brain injury, cerebrovascular ischaemia or haemorrhage; this will influence the preferred blood pressure target. Central venous pressure can be influenced by multiple pathophysiological factors and, unless central venous pressure is very low, it is rarely useful as a predictor for fluid responsiveness. Central venous oxygen saturation can be easily increased by a high arterial oxygen tension, making it useless as a surrogate marker of good cardiac output or systemic oxygen delivery in the presence of hyperoxaemia. Many dynamic haemodynamic indices have been reported to predict fluid responsiveness, but they all have their own limitations. There is also insufficient evidence to support that giving fluid until the patient is no longer fluid responsive can improve patient-centred outcomes. With the exception in the context of preventing contrast-induced nephropathy, large randomised controlled studies suggest that excessive fluid treatment may prolong duration of mechanical ventilation without preventing acute kidney injury in the critically ill.
Procedural Pain does not raise Plasma Levels of Cortisol or Catecholamines in Adult Intensive Care Patients after Cardiac Surgery
Authors: van Gulik L. , Ahlers S. J. G. M. , van Dijk M. , Bruins P. , Meima M. E. , de Rijke Y. B. , Biemond-Moeniralam H. S. , Tibboel D. , Knibbe C. A. J.
Published: January 2019

The gold standard for quantification of pain is a person's self-report. However, we need objective parameters for pain measurement when intensive care patients are not able to report pain themselves. An increase in pain is currently thought to coincide with an increase in stress hormones. This observational study investigated whether procedure-related pain is associated with an increase of plasma cortisol, adrenaline, and noradrenaline. In 59 patients receiving intensive care after cardiac surgery, cortisol, adrenaline, and noradrenaline plasma levels were measured immediately before and immediately after patients were turned for washing, with or without concurrent removal of drain tubes. Numeric rating scale scores were obtained before, during, and after the procedure. Unacceptably severe pain (numeric rating scale ≥4) was reported by seven (12%), 26 (44%), and nine (15%) patients, before, during and after the procedure, respectively. There was no statistically significant association between numeric rating scale scores and change in cortisol, adrenaline, and noradrenaline plasma levels during the procedure. Despite current convictions that pain coincides with an increase in stress hormones, procedural pain was not associated with a significant increase in plasma stress hormone levels in patients who had undergone cardiac surgery. Thus, plasma levels of cortisol, adrenaline, and noradrenaline seem unsuitable for further research on the measurement of procedural pain.
Discordance between ROTEM® clotting time and conventional tests during unfractionated heparin–based anticoagulation in intensive care patients on extracorporeal membrane oxygenation
Authors: Prakash S. , Wiersema U. F. , Bihari S. , Roxby D.
Published: January 2019

We hypothesised that ROTEM® (Basel, Switzerland) INTEM® (ROTEM, Basel, Switzerland) clotting time (CT) would have good agreement with activated partial thromboplastin time (aPTT) in determining whether a dose adjustment should be made to the unfractionated heparin (UFH) infusion in patients on extracorporeal membrane oxygenation. All patients treated with extracorporeal membrane oxygenation over a five-year period were included for data analysis. Retrospective analysis was performed of prospectively collected data points, wherein aPTT, activated CT and ROTEM was performed simultaneously to monitor UFH–based anticoagulation. Two hundred data points were available for analysis. Turnaround time was shortest for activated CT followed by ROTEM and aPTT. Despite achieving therapeutic aPTT targets, the majority (>50%) of INTEM CT results were within normal limits. The aPTT and INTEM CT results correlated weakly (r=0.31, 95% confidence interval [0.17, 0.43]) and there was no agreement between the directional changes of aPTT and INTEM CT results on successive days (χ2 = 2.33, P=0.17). Due to relative insensitivity, INTEM CT–guided UFH titration was estimated to result in a 289% increase in incidence of up-titration, over aPTT–guided titration. The INTEM CT results (r=0.36, 95% confidence interval [0.23, 0.48]) correlated weakly with UFH infusion rates. The UFH infusion rate only explained 13% variability in INTEM CT values. While haemorrhagic complications were frequent, no major clotting complications were encountered. Our results demonstrated that aPTT and INTEM CT do not provide equivalent information to guide UFH infusion rate titration during extracorporeal membrane oxygenation. Our study suggests caution regarding the use of ROTEM for guiding UFH–based anticoagulation as it may lead to excessive UFH exposure.
Reliability of the Direct Observation of Procedural Skills assessment tool for ultrasound-guided regional anaesthesia
Authors: Chuan A. , Thillainathan S. , Graham P. L. , Jolly B. , Wong D. M. , Smith N. , Barrington M. J.
Published: January 2019

Summary

The Direct Observation of Procedural Skills (DOPS) form is used as a workplace-based assessment tool in the current Australian and New Zealand College of Anaesthetists curriculum. The objective of this study was to evaluate the reliability of DOPS when used to score trainees performing ultrasound-guided regional anaesthesia. Reliability of an assessment tool is defined as the reproducibility of scores given by different assessors viewing the same trainee. Forty-nine anaesthetists were recruited to score two scripted videos of trainees performing a popliteal sciatic nerve block and an axillary brachial plexus block. Reliability, as measured by intraclass correlation coefficients, was −0.01 to 0.43 for the individual items in DOPS, and 0.15 for the ‘Overall Performance for this Procedure’ item. Assessors demonstrated consistency of scoring within DOPS, with significant correlation of sum of individual item scores with the ‘Overall Performance for this Procedure’ item (r=0.78 to 0.80, P <0.001), and with “yes” versus “no” responses to the ‘Was the procedure completed satisfactorily?’ item (W=24, P=0.0004, Video 1, and W=65, P=0.003, Video 2). While DOPS demonstrated a good degree of internal consistency in this setting, inter-rater reliability did not reach levels generally recommended for formative assessment tools. Feasibility of the form could be improved by removing the ‘Was the procedure completed satisfactorily?’ item without loss of information.
The Anaesthetic Assessment, Management and Risk Factors of Bariatric Surgical Patients requiring Postoperative Intensive Care Support: A State-Wide, Five-Year Cohort Study
Authors: Morgan D. J. R. , Ho K. M.
Published: January 2019

Summary

Bariatric surgery is a rapidly growing and dynamic discipline necessitating a specialised anaesthetic approach coordinating high-risk patients with appropriate postoperative intensive care (ICU) support. The relationship between the anaesthetic and ICU utilisation after bariatric surgery is poorly understood. All adult bariatric surgery patients admitted to any ICU over a five-year period between 2007 and 2011 in Western Australia were identified from hospital admission records and cross-referenced against the Western Australian Department of Health Data Linkage Unit database. During the study period 12,062 patients underwent bariatric surgery with 581 (4.8%) patients admitted to ICU immediately following surgery. The mean preoperative ASA score was 3.3 (standard deviation 1.1) with 76.9% of patients assessed by their anaesthetist for the first time on the day of surgery. Blood pathology (75%) and ECG (46.3%) were the most common preoperative investigations. Intraoperatively, 2.1% of patients had a grade 4 intubation with only 3.4% of patients requiring video-assisted intubation. Despite being deemed at high risk, 23.6% of patients were managed with 20 Gauge or smaller intravenous access. Anaesthetic complications were extremely uncommon (0.5% of all bariatric cases) but accounted for 9.7% of all postoperative ICU admissions. Smoking history, but not body mass index ( P=0.46), was the only significant prognostic factor for respiratory or airway-related anaesthetic complications ( P=0.012). In summary, the anaesthesia management of bariatric surgery varied widely in Western Australia, with smoking as the only significant preoperative risk factor for respiratory or airway-related anaesthesia complications.
Intravenous Lipid Emulsion for Levobupivacaine Intoxication in Acidotic and Hypoxaemic Pigs
Authors: Heinonen J. A. , Skrifvars M. B. , Haasio J. , Backman J. T. , Rosenberg P. H. , Litonius E.
Published: January 2019

Intravenous lipid emulsion is, in some countries, the recommended treatment for local anaesthetic toxicity. Systemic local anaesthetic toxicity results in hypoxaemia and acidosis, and whether this influences the effects of lipid therapy on drug concentrations and cardiovascular recovery is currently unknown. Twenty anaesthetised pigs were given a 3 mg/kg bolus of levobupivacaine followed by a five-minute phase of hypoventilation and 1 mmol/kg of lactic acid over one minute. After lactic acid infusion, pigs were treated, in randomised order, with either 20% lipid emulsion or Ringer's acetate for 30 minutes: a 1.5 ml/kg bolus followed by a 0.25 ml/kg/minute infusion. Haemodynamic parameters were recorded and blood samples were collected for pharmacokinetic analysis. There was no difference between the groups in the area under the plasma levobupivacaine concentration–time curve (AUC) or between that and AUC of unentrapped levobupivacaine in the Lipid group, or in the plasma half-lives. The cardiovascular outcome and normalisation of the electrocardiogram were similar in both groups. Five pigs developed marked hypotension: one in both groups died, while two in the Lipid group and one in the Ringer group needed adrenaline. Administration of lipid emulsion did not improve cardiovascular recovery from levobupivacaine toxicity exacerbated by acidosis and hypoxaemia. Lipid emulsion did not entrap levobupivacaine or affect levobupivacaine pharmacokinetics.
The Effect of Adjuvant Remifentanil with Propofol or Thiopentone on Seizure Quality during Electroconvulsive Therapy
Authors: MacPherson R. , Marroquin-Harris M. , Gálvez V. , Tor P. , Loo C.
Published: January 2019

In order to optimise outcome to electroconvulsive therapy (ECT), there has been a trend to remifentanil as an adjunct to standard intravenous induction agents. This has allowed a reduction in the dose of anaesthetic agent, and usually an improved response to stimulation. However there have been no previous studies to ascertain whether this improvement is simply as a result of the reduced dose of anaesthetic agent or whether remifentanil itself might possess epileptogenic properties. This retrospective case-controlled study examined ECT outcomes, determined by electroencephalography (EEG) quality analysis, in patients who received ECT with or without remifentanil, where there was no dose reduction in the anaesthetic agent. There were no improvements seen in the measurements of any EEG parameter, including seizure duration. These observations suggest that remifentanil does not possess any intrinsic proconvulsant activity and that any improvement in outcome seen with its use is as a result of dose reduction in the IV anaesthetic agent.
Night Shift Fatigue among Anaesthesia Trainees at a Major Metropolitan Teaching Hospital
Authors: Lancman B. M.
Published: January 2019

Night shifts expose anaesthesia trainees to the risk of fatigue and, potentially, fatigue-related performance impairment. This study examined the workload, fatigue and coping strategies of anaesthesia trainees during night shifts. A blinded survey-based study was undertaken at a major single centre metropolitan teaching hospital in Australia. All ten anaesthesia trainees who worked night shifts participated. The survey collected data on duration of night shifts, workload, and sleep patterns. Fatigue was assessed using the Karolinska Sleepiness Scale (KSS). There were 93 night shifts generating data out of a potential 165. Trainees tended to sleep an increasing amount before their shift as the nights progressed from 1 to 5. Night 1 was identified as an ‘at risk’ night due to the amount of time spent awake before arriving at work (32% awake for >8 hours); on all other nights trainees were most likely to have slept 6–8 hours. The KSS demonstrated an increase in sleepiness of 3 to 4 points on the scale from commencement to conclusion of a night shift. The Night 1 conclusion sleepiness was markedly worse than any other night with 42% falling into an ‘at-risk’ category. The findings demonstrate fatigue and inadequate sleep in anaesthesia trainees during night shifts in a major metropolitan teaching hospital. The data obtained may help administrators prepare safer rosters, and junior staff develop improved strategies to reduce the likelihood of fatigue.
A Prospective Observational Study of the Association between Cabin and outside Air Temperature, and Patient Temperature Gradient during Helicopter Transport in New South Wales
Authors: Miller M. , Richmond C. , Ware S. , Habig K. , Burns B.
Published: January 2019

The prevalence of hypothermia in patients following helicopter transport varies widely. Low outside air temperature has been identified as a risk factor. Modern helicopters are insulated and have heating; therefore outside temperature may be unimportant if cabin heat is maintained. We sought to describe the association between outside air, cabin and patient temperature, and having the cabin temperature in the thermoneutral zone (18–36oC) in our helicopter-transported patients. We conducted a prospective observational study over one year. Patient temperature was measured on loading and engines-off. Cabin and outside air temperature were recorded for the same time periods for each patient, as well as in-flight. Previously identified risk factors were recorded. Complete data was obtained for 133 patients. Patients' temperature increased by a median of 0.15oC ( P=0.013). There was no association between outside air temperature or cabin temperature and patient temperature gradient. The best predictor of patient temperature on landing was patient temperature on loading (R2=0.86) and was not improved significantly when other risk factors were added ( P=0.63). Thirty-five percent of patients were hypothermic on loading, including those transferred from district hospitals. No patient loaded normothermic became hypothermic when the cabin temperature was in the thermoneutral zone ( P=0.04). A large proportion of patients in our sample were hypothermic at the referring hospital. The best predictor of patient temperature on landing is patient temperature on loading. This has implications for studies that fail to account for pre-flight temperature.
Minimally Invasive Cardiac Output Monitoring: Agreement of Oesophageal Doppler, LiDCOrapid™ and Vigileo FloTrac™ Monitors in Non-Cardiac Surgery
Authors: Phan T. D. , Kluger R. , Wan C.
Published: January 2019

There is lack of data about the agreement of minimally invasive cardiac output monitors, which make it impossible to determine if they are interchangeable or differ objectively in tracking physiological trends. We studied three commonly used devices: the oesophageal Doppler and two arterial pressure–based devices, the Vigileo FloTrac™ and LiDCOrapid™. The aim of this study was to compare the agreement of these three monitors in adult patients undergoing elective non-cardiac surgery. Measurements were taken at baseline and after predefined clinical interventions of fluid, metaraminol or ephedrine bolus. From 24 patients, 131 events, averaging 5.2 events per patient, were analysed. The cardiac index of LiDCOrapid versus FloTrac had a mean bias of −6.0% (limits of agreement from −51% to 39%) and concordance of over 80% to the three clinical interventions. The cardiac index of Doppler versus LiDCOrapid and Doppler versus FloTrac, had an increasing negative bias at higher mean cardiac outputs and there was significantly poorer concordance to all interventions. Of the preload-responsive parameters, Doppler stroke volume index, Doppler systolic flow time and FloTrac stroke volume variation were fair at predicting fluid responsiveness while other parameters were poor. While there is reasonable agreement between the two arterial pressure–derived cardiac output devices (LiDCOrapid and Vigileo FloTrac), these two devices differ significantly to the oesophageal Doppler technology in response to common clinical intraoperative interventions, representing a limitation to how interchangeable these technologies are in measuring cardiac output.