bluuebunny/crossref_metadata_2025 huggingface dataset:
Aripiprazole use as a cause of dopamine agonist failure in the treatment of prolactinomas
Authors: Mignone Edward , Jukes Alistair K , Valentine Rowan , Allison Richard , De Sousa Sunita M C
Published: December 2024

Prolactinomas are the most common hypersecretory pituitary adenoma. The traditional first-line therapy is dopamine agonists (DAs), which are highly effective and tolerated in the majority of cases. However, DAs have the potential for psychiatric complications, such as psychosis, impulse control disorders and anxiety/depression. It has been repeatedly suggested that aripiprazole may be considered in individuals with a psychiatric disorder and prolactinoma, potentially enabling DA dose reduction or even cessation. We report the first case of aripiprazole competing with cabergoline and reducing its efficacy in the treatment of a giant prolactinoma, as evidenced by an immediate and marked rise in serum prolactin (approximately 350% increase over 5 weeks) despite stable cabergoline dosing. We also present a systematic review of aripiprazole use in prolactinomas, showing that aripiprazole monotherapy effectively reduces serum prolactin and concurrently commenced aripiprazole/DA dual therapy may still permit prolactin lowering, although there were no previous cases where aripiprazole was added to an established DA therapy to indicate the direct effect of aripiprazole on DA efficacy. Based on our case, we support close monitoring of individuals with prolactinomas on dual aripiprazole/DA therapy and recommend against the addition of aripiprazole to DA therapy where timely prolactinoma treatment is essential (e.g. aggressive prolactinomas and those associated with compressive effects).
EN TORNO A LA EXPECTATIVA Y EL TRIUNFO MILITAR: BRIHUEGA Y VILLAVICIOSA EN LA GRAND STRATÉGIE DIPLOMÁTICA FRANCESA
Authors: Díaz Paredes Aitor
Published: December 2024

Este artículo analiza el impacto de las victorias militares obtenidas por el duque de Vendôme en Brihuega y Villaviciosa de Tajuña los días 9 y 10 de diciembre de 1710 en las conversaciones conducidas por la diplomacia francesa durante las fases preliminares a los acuerdos de paz de Utrecht. Gracias a la inercia adquirida en el campo de batalla, el marqués de Torcy, a través de distintos agentes, sondeó soluciones alternativas a las negociaciones de paz con Gran Bretaña, cada vez más avanzadas. Esta aproximación pragmática a las posibilidades que ofrecía el triunfo militar nos permite destacar la relevancia de la batalla como un evento diplomático con la capacidad de influir en los procesos de paz y, en un sentido más amplio, propone una perspectiva que subraya la diplomacia a través de la fuerza como parte integral de las relaciones internacionales.
Diastasis recti in children – results of ultrasonographic study
Authors:   Department of Anatomy, Institute of Medical Sciences, University of Opole, Opole, Poland, Kawalec-Rutkowska Agata Maria , Simka Marian ,   Department of Anatomy, Institute of Medical Sciences, University of Opole, Opole, Poland
Published: December 2024

Aim: Diastasis recti is a common contour abnormality of the anterior abdominal wall, where an increased distance between the rectus abdominis muscles results in a visible or palpable bulge in this area. This study aimed to characterize this clinical entity in children. Material and methods: Anatomy of the rectus abdominis muscles and the linea alba, with a special focus on the interrectus distance (distance between two bellies of the rectus abdominis muscles), was studied using ultrasound. Anthropometric and ultrasonographic assessments were performed on 38 children aged 7–12 years. According to the clinical definition of bulging in the epigastrium, diastasis was diagnosed in 12 children (31.6%), significantly more often in boys than in girls (50.0% vs. 6.3%). Other clinical and anthropometric variables, such as age, history of preterm birth, body mass, body mass index, waist circumference, and height, were not significantly associated with diastasis recti. Results: Diastasis recti, defined by the ultrasonographic criterion of interrectus distance >20 mm, was found in 10 children (26.3%), with no significant differences between boys and girls. Still, there was a moderate agreement between these two modes of diagnosing diastasis: the Cohen’s kappa coefficient was 0.49. This suggests that ultrasonographic measurement of the interrectus distance should not be considered an alternative and more precise method of diagnosing diastasis. Conclusions: Our study indicates that diastasis recti is quite common in the pediatric population, especially among boys. However, more studies are needed in children to understand the functional relevance and natural course of this clinical entity.
«Гневные толпы, восставшие против произвола властей» О пресуппозициях и их функциях в научно-популярных текстах на материале книги «Москва: иллюстрированная история» (1985–1986)
Authors: Красникова Анна , Нозеда Валентина
Published: December 2024

Пресуппозиции, как и другие виды инференции, составляют важнейший компонент вербальной коммуникации, позволяя говорящим порождать высказывания, удовлетворяющие принципу эко-номии языковых средств. В любом тексте cодержание можно разделить на утверждаемое и подразу-меваемое, то есть находящееся в пресуппозиции. Чаще всего адресат соглашается с пресуппозици-ями, то есть принимает пресуппозиционное содержание как истинное, и именно это обеспечивает успешное развитие коммуникации. Однако коммуникативные свойства пресуппозиций могут быть использованы в манипулятивных целях, чтобы представить как самоочевидное и неоспоримое то, что на самом деле является ложным и сомнительным. Один из самых известных примеров — Der Wille des Volkes, «воля народа», который приводил еще Готлоб Фреге (1892): в этом выражении оши-бочно предполагается существование одной единственной воли всех людей, относящихся к тому или иному народу. Фреге первым затронул и проблему манипулятивного потенциала пресуппози-ций. После него ряд ученых обращались к исследованию манипулятивного эффекта пресуппози-ций в различных типах текстов, особенно политических. Тем не менее, до сих пор практически нет работ, в которых бы использование пресуппозиций для передачи адресату определенной картины мира рассматривалось бы на русскоязычном материале.

В данной статье наличие и использование пресуппозиций, а также их потенциально манипуля-тивные функции анализируются на примере книги «Москва: иллюстрированная история» (1985– 1986) — этот выбор обусловлен намерением изучить тексты, не относящиеся к категории откро-венно пропагандистских, где большая часть пропагандистского содержания выражена в ассерции. Исследование показывает, какие идеи заложены в пресуппозициях, насколько регулярно использо-вался этот прием и какое неоспоримое представление о реальности создавалось в результате. Боль-шинство идей, заложенные в текстах, можно свести к следующим: наличие единой многонацио-нальной страны, которая существовала на протяжении всей русской истории и в которой Москва уже с ранних веков была главным центром; отождествление всех государств, в которых русский народ был титульным, от Киевской Руси до Советского Союза; представление о том, что Россия всегда была окружена врагами; неизбежность классовой борьбы на всех этапах развития истории.

Очевидно, что эффект манипуляции зависит от социально-исторического контекста. Следова-тельно, представленные здесь тексты, скорее всего, воспринимались читателями того времени, по-груженными в пропитанную пропагандой среду, как связные и конгруэнтные.
Three newly reported escaped non-native Costus L. species (Costaceae) in Java, Indonesia
Authors: Irsyam Arifin Surya Dwipa , Hariri Muhammad Rifqi , Fadhil Muhammad Hisyam , Al Anshori Zakaria , Dewi Asih Perwita , Peniwidiyanti Peniwidiyanti , Kurniawan Muhammad Fabio Rayhan , Baidlowi Muhammad Hisyam , Rosleine Dian
Published: December 2024

Costus L. is the most species‑rich genus in Costaceae and is mainly distributed in the Neotropics and tropical Africa. Five Costus species have been introduced to Java, Indonesia, for ornamental purposes. During our botanical expeditions in Java from January to May 2023, we discovered three previously unreported species of Costus that occur spontaneously in the wild: C. phyllocephalus K.Schum., C. spicatus (Jacq.) Sw., and C. villosissimus Jacq. Their spontaneous populations have been found on roadsides and abandoned areas in West Java.
Current considerations on the dominant microbiota in orthodontic ligatures
Authors: López Valencia D. , Nieto Aguilar R. , Aguilera Méndez A.
Published: December 2024

Objective: To determine the dominant microbiota on elastic and metal orthodontic ligatures, as well as the degree of growth and proliferation, for use in interceptive orthodontics.
Methods: Multiple cultures were generated and analyzed from samples from elastic and metallic ligatures from 5 orthodontic patients and after 4 weeks of treatment. Briefly, a total of 180 culture samples were cultured and analyzed using blood base agar, mannitol salt agar, chocolate agar, chromoagar, and McConkey agar. Statistical interpretation of the quantitative results was carried out.
Results: It was found that metal ligatures presented lower bacterial growth and proliferation, regardless of the brand used, compared to elastic ligatures, including an equal time treatment period. Greater variability of microorganism species was evident in elastic ligations compared to metallic ligations.
Conclusion: elastic ligation presents greater susceptibility for bacterial colonies generation than the metallic ligation. In turn, metallic ligation should be preferred to elastic ligation if possible and depending on the type of treatment, for its use at the orthodontic clinic.
Proposal for the Breakdown of the Objectives of Technical Education in 3. Cycle of Primary School in the Light of the New School Reform
Authors: PAVELKA JOZEF
Published: December 2024

In relation to the aims and objectives of the ongoing curriculum reform in Slovakia, the study presents a possible approach to working with the newly conceived educational objectives of technical education in primary schools in Slovakia, based on an analysis of the educational area of Man and the World of Work.
The Examination of the Popularity and Development of the CodeCup Team Competition
Authors: BLÉNESSY GABRIELLA
Published: December 2024

International Informatics Olympiad in Teams (IIOT) is a competition for teams of high school students, organized since 2017. Hungary first participated in 2021. CodeCup, our national qualifier competition, gradually gained popularity over the past three years. In 2023–2024, teams have competed in four qualifying rounds. The goal of our research was to find means of increasing the number of competitors in CodeCup, and potentially in other national qualifier competitions as well. Primarily, we wanted to measure the effects of recent changes in the competition rules. We examined trends in the participation of the last three years: the list of involved schools, the age and gender distribution of students, with special regard to the impact of Program’Petition, a lightweight teer of CodeCup, launched in 2023. The results show that the number of schools has not changed significantly, but the number of competitors and the ratio of girls has increased.
Teacher Qualifications – an Important Factor in the Subject of Technology
Authors: LUKÁČOVÁ DANKA , BÁNESZ GABRIEL
Published: December 2024

The subject of technology in primary schools has not been sufficiently provided with space and material since the reform changes in 2008 and subsequently since the curriculum innovation in 2015. Research by several authors points to this fact. In this article, we investigate the relationship between the views of teachers of the subject of technology on the material and technical equipment of schools for teaching this subject and the qualification of teachers.
Un-Words as a Factor of Ideologization in the Modern German Political Discourse
Authors: Guseynova Innara , Gorozhanov Alexey
Published: December 2024

The research attempts to establish the content component of un-words that have recently entered the modern political discourse of Germany, represented by a corpus of texts from federal and regional media that form a negative agenda, from the point of view of the difficulties they present for their interpretation by the reader. These include: the problem of terminological ambisemy, neologisms that are multi-component words, evaluative vocabulary containing negative connotations in relation to representatives of other cultures of migrant origin, as well as catchwords and expressions that include a retro component. The lexemes Remigration, Heizungs-Stasi, Doppelwumms, Kriegstьchtigkeit, Gamechanger, Sondervermцgen, Stolzmonat, Technologieoffenheit, Klimakleber, etc. have been examined. The lexical-semantic method with elements of discourse and content analysis, contextual analysis, as well as elements of word-formation analysis were used during the study. Such a complex combination of various methods is due to the fact that the analyzed language units are not recorded in lexicographic sources, glossary dictionaries and reference literature. It was stated that the most popular topics that form a negative agenda are the problem of migration, environmental and environmental-social problems associated with a decrease in the standard of living of German citizens, unsuccessful rhetoric of the political elite containing statements that affect the implementation of Germany’s internal and foreign policy.
Linguacultural Patterns of Foreignness Verbalization in Source Text and Its Translation in the Literary Discourse
Authors: Fadeeva Marina
Published: December 2024

The category of “foreignness”, being the extreme form of “otherness” manifestation, is examined in the article through the peculiarities of its representation in translated fiction. The images of characters and the surrounding them narrative picture embody the “alien” motive at the level of contents and linguistic-and-stylistic structure of the text, which provokes certain difficulties in choosing lexical equivalents in translation. The purpose of the study is to identify linguacultural patterns of “foreignness” verbalization in the literary discourse and to describe translation techniques that enable the conveyance of “otherness” in translation. The empirical basis of the study consists of more than 50 contexts obtained by continuous sampling method from the Russian National Corpus, a subcorpus of parallel texts in Russian and German, applying the specified search parameters: “chuzhoy” / “chuzhdyy” (“foreign” / “alien”) and their derivatives. Based on the classification of types of foreignness proposed by B. Waldenfels, it is shown that objectification of familiar, structural and radical foreignness in the factual material is realized through toponyms, realia, foreign language inclusions, precise vocabulary, adjectives with positive, neutral or negative connotations. Familiar foreignness is noted to be subjected to functional translation using full equivalents, generalization and description. Language forms of structural and radical foreignness require differentiation of meanings, choosing contextual analogues and holistic transformation.
Enhancing cardio-cerebrovascular therapy through biomimetic platelet membrane coating
Authors: S Akshara , F A Sanjane , Rubab Tanzil , Shalom R Nikitha , Narayan Shoba
Published: December 2024

Integrating nanotechnology and biomimetic techniques is a significant progress in disease management. This review focuses on the application of platelet membrane–based biomimetic carriers and emphasizes their potential use in cardio-cerebrovascular therapy. Platelet membranes have attracted significant interest because of their distinctive characteristics, specifically in blood clotting and the healing of wounds; research is focused on utilizing the inherent characteristics of platelet membranes to develop novel methods for delivering drugs. Bilayer that is characteristic of platelet membrane–coated nanoparticles enables effective encapsulation and transportation of therapeutic drugs, rendering them suitable as drug delivery vehicles. Even so, the difficulties linked to drug administration using platelet membranes, such as the possibility of causing an immune response or having limited mechanical qualities, can be resolved by employing natural or imitated methods. For instance, spider silk, whether in its native form or modified, can be used as a template to enhance mechanical characteristics of platelet membranes, increasing their appropriateness for drug delivery purposes. In addition, including other features, such as PEGylation or antioxidant encapsulation, can further improve effectiveness of platelet membrane–coated nanoparticles. This review provides insight into using nanoparticles coated with platelet membranes and biopolymers as carriers for cardiovascular and cerebrovascular therapies.
Thames Water service reservoir stability investigations
Authors: Miller Neil , Cox Robert
Published: December 2024

In 2021, Thames Water commissioned a project to evaluate and prioritise the refurbishment of embankments for 12 non-statutory service reservoirs in the Thames Valley Operational area. The goal was to create customised technical solutions and a prioritisation plan for refurbishment at each site. Historical data and site inspections by geotechnical engineers were used to identify issues and determine the need for further investigations. The cost of ground investigation for all 12 sites was higher than the client suggested, and a re-evaluated approach was to prioritise ground investigation and slope analysis for higher-risk embankments. The key findings from these investigations highlighted the significance of environmental conditions, climate change, control of burrowing animals, the effect that roof leak tests can have on embankment stability, and appropriate backfilling methods for embankment design. The project involved slope analysis of the embankments and recommendations for improvements for each non-statutory service reservoir embankment.
Strain rate-dependent undrained response of a coral sand
Authors: Saqib M. , Das S. K. , Das A.
Published: December 2024

The strain rate-dependent response of sand is influenced by particle crushing. However, such a conclusion is drawn in the previous studies, primarily based on drained triaxial or 1D compression tests on crushable sand. This study explores the interplay of strain rate and crushing behaviour of sand under undrained triaxial (CU) conditions. We perform CU tests on coral sand under different confining pressures and relative densities. Two different axial strain rates in the quasi-static range are used to explore the rate-sensitive response of coral sand. The undrained experiments reveal that a slow strain rate and high confining pressure lead to higher crushing, as commonly observed in drained triaxial experiments since dilatancy diminishes. However, CU tests on dense samples also demonstrate higher crushing than medium dense samples, which is a counterintuitive observation. Later, it is analysed that crushing evolution before and after phase transformation and corresponding pore pressure generation plays a pivotal role in the undrained response. In addition, strain rate also governs the particle crushing and peak strength of the sand samples. This study proposes a generalized rate-dependent breakage index that satisfactorily predicts the correlation between relative breakage and plastic work under different rates, relative densities, and confining pressures.
Flow path tortuosity in saturated porous media comprising idealised spherical particles
Authors: Cao W. , Hu N. , Hofmann H. , Scheuermann A.
Published: December 2024

Extensive research has been conducted on tortuosity–porosity relationships for porous media. However, the relationship remains unclear, particularly when the porosity falls within the range 0·2–0·5, which covers most granular geomaterials. This study proposes a novel tortuosity–porosity model for estimating tortuosity in saturated porous media. Syringe tests were conducted by simulating seepage flow through a porous medium under Darcy’s law. The tortuosity was achieved after determining the porosity and permeability using the volumetric saturation method and constant-head method, respectively. Compared with existing models, the proposed model exhibited consistency at porosity values above 0·5 and improved smoothness as the porosity approached 0·2, which outperformed them in accurately predicting the tortuosities in these experiments. In addition, a sensitivity analysis against porosity demonstrated its precision, thereby facilitating its engineering application. These experimental results and model predictions provide valuable insights into the influence of pore geometry on flow paths and corresponding tortuosities.
ESTIMATION OF INITIAL RESERVOIR PRESSURE BASED ON A «SHORT» PRESSURE BUILD-UP FOR LOW-PERMEABILITY FORMATION
Authors: Bobreneva Yu.O. , Makhota N.A. , Davletbaev A.Ya. , Miroshnichenko V.P. , Shchutskii G.A. , Efremov A.N. , Sergeychev A.V. , Yulmukhametov D.R.
Published: December 2024

The paper proposes an approach for estimating reservoir pressure in newly drilled zones with low and ultra-low reservoir permeability (1∙10-17 – 1∙10-15 m2). Under such conditions, traditional types of well-testing are not carried out. This approach consists of a short shutdown of the production well for testing to restore bottomhole pressure after its short operation. The method is an analogue of the classical well-testing using the pressure build-up method, but has the advantage of a short well shutdown time. The name of the research method under consideration is a «short» pressure build-up. The proposed method does not require significant research costs and can be applied to all types of well completions, while significantly reducing production losses compared to the traditional method. The paper describes an algorithm for conducting research using this approach. The results of modeling «short» pressure build-up for various well operation scenarios and reservoir parameters are presented. Based on the modeling, a matrix of applicability of the method was constructed, which allows one to estimate the required duration of the study and the relative error of the resulting reservoir pressure. The defining parameter is the ratio of the volume of injected fluid during hydraulic fracturing to the volume of fluid taken during the period of well operation before stopping for testing. The proposed method was tested on field studies, based on the results of which the values of reservoir pressures and their reliability were determined. Materials and methods of the study: flow rate and bottomhole pressure measurements, information from reports on hydraulic fracturing; interpretation of the conducted «short» pressure recovery curves, modeling of the study in the RN-VEGA PC.
INVESTIGATING THE LONG-TERM EFFECTIVENESS OF PIPELINE THERMAL INSULATION: A STUDY OF DENSITY, MOISTURE CONTENT, AND THERMAL CONDUCTIVITY
Authors: Pascal M.A.V. , Kuleshov A.I. , Ogunsola A.T. , Hasanov R.R. , Kantemirov I.F.
Published: December 2024

The article considers the study of thermal insulation samples in order to determine changes in its properties during operation, namely density, moisture retention and thermal conductivity. According to the results of the study, it was determined that the values of these indicators do not meet the requirements of regulatory documents. In addition, it was determined that thermal insulation samples with the highest moisture content have the worst thermal conductivity. This may be due to a change in the structure of thermal insulation due to freezing and thawing of water trapped in thermal insulation during the operation of pipelines.
METHODICAL APPROACHES FOR BITUMEN PROPERTIES STUDYING AND ITS CONTENT ASSESSING IN CARBONATE DEPOSIT CORE SAMPLES OF EASTERN SIBERIA
Authors: Zagidullin M.I. , Sycheva A.S. , Markov V.V. , Vtorushina E.A. , Shulga R.S. , Gilmanov Ya.I.
Published: December 2024

Oil and gas fields in Eastern Siberia play an important, strategic role in the development and reproduction of hydrocarbon reserves. Oil and gas-bearing carbonate rocks of the Lower Cambrian deposits are characterized by a complex structure of the pore space, which is represented by intercrystalline, interform, intraform voids, caverns and cracks, partially filled with sulfates, halite due to secondary changes. Hydrocarbons are represented by gas, oil and bitumen. Black and, less often, black-brown bitumen occurs in the form of films and smears along the contours of crystals and the walls of voids, partially or completely sealing them in some areas. Bitumen can fill almost all available void space, significantly worsening well flow rates, sometimes reducing them to a minimum. A reliable assessment of the void space of carbonate reservoirs is necessary for a correct evaluation of hydrocarbon reserves of raw materials, as well as for planning an effective development system for such objects. The largest volume of data on petrophysical and lithological-mineralogical properties of rocks, as well as their oil and gas saturation, is obtained during geophysical well logging (GWL), however, to obtain reliable results of GWL interpretation, a reliable petrophysical basis is required, which is created as a result of a comprehensive study of core and reservoir fluids. This paper examines methodological approaches to studying the properties of bitumen and assessing its content in core samples of carbonate deposits in Eastern Siberia. The objects of research are rocks of oil-saturated formations Б1 and Б5 in several fields in Eastern Siberia, located in the area of activity of Oil Company Rosneft PJSC.
Spin-dependent multichannel tunneling of electron in a quantum wire in a longitudinal magnetic field
Authors:   Yerevan State University, MURADYAN A.ZH. , BADALYAN D.A. ,   Yerevan State University
Published: December 2024

Multichannel quantum tunneling of an electron flow through the potential barrier of thin impurity embedded in a quantum wire in a longitudinal magnetic field has been studied. Analytical expressions for the tunneling coefficient and the spin polarization coefficient are obtained. It is shown that channels other than the input ones are formed only at a transversely inhomogeneous impurity potential. The efficiency of their generation increases with increasing concentration of the tunneling potential in the center of the nanowire and does not depend on the sign of the potential. The channels have different degrees of polarization, and in a certain energy region of each newly formed channel, the tunneling current is completely polarized. Key results of the work are also illustrated graphically.
Influence of the dimensional quantization effects on the effective mass of majority charge carriers in LED heterostructures with InxGa1−xN/GaN multiple quantum wells
Authors:   Lomonosov Moscow State University, BURMISTROV E.R. , AVAKYANTS L.P. ,   Lomonosov Moscow State University, KUTYREV G.YU. ,   Lomonosov Moscow State University
Published: December 2024

The zone diagrams of LED heterostructures with In x Ga1- x N/GaN multiple quantum wells are calculated by numerical self-consistent solution of the system of Schrodinger equations and Poisson electroneutrality. The influence of the electron-phonon interaction, the nonparabolicity of the dispersion law, and the hybridization of the wave function on the values of the effective mass of the majority charge carriers in In x Ga1- x N/GaN quantum wells has been studied. The redshift of 2D plasmon resonances is associated with the temperature renormalization of the effective mass of two-dimensional carriers. To describe the temperature dependence of the effective mass, the function of displacement of the 2D plasmon resonance frequency is used.
Development of cyclic creep under block loading of semi-crystalline peek
Authors:   Institute of Strength Physics and Materials Science of the Siberian Branch of the Russian Academy of Sciences, BOGDANOV A.A. , PANIN S.V. ,   Institute of Strength Physics and Materials Science of the Siberian Branch of the Russian Academy of Sciences, LYUBUTIN P.S. ,   Institute of Strength Physics and Materials Science of the Siberian Branch of the Russian Academy of Sciences, OSTAPENKO M.G. ,   Institute of Strength Physics and Materials Science of the Siberian Branch of the Russian Academy of Sciences
Published: December 2024

The effect of creep development that occurs under cyclic loading of polyetheretherketone (PEEK) is studied, where the cyclic creep parameter is used to quantitatively characterize the structure rearrangement. The magnitude of cyclic creep was calculated from mechanical hysteresis loops. To obtain the dependence of the magnitude of cyclic creep on the amplitude of the external cyclic stress, block loading was carried out with a stepwise increase in the amplitude. It is shown that the mechanism of development of cyclic creep under block loading has a two-stage character. The first stage is responsible for the adaptation of the polymer to an increase in the applied load. The second stage corresponds to stabilization, when the rate of creep development slows down, and its further development stops. It was found that despite the restructuring of the structure and the hardening caused by it, the degree of crystallinity under cyclic loading did not change and amounted to 59%. At the same time, the value of microstresses decreased from 6 to 0.9 MPa. It has been shown that cyclic strain hardening with a block increase in load can lead to an increase in the fatigue life of PEEK (which can reach 90% of the ultimate strength of the material).
Efficacy and mechanisms of curcumin in the treatment of osteoarthritis: A scoping review
Authors: Ma Xiaodong , Zhao Wenjian , Yang Fan , Chin Kok-Yong
Published: December 2024

Osteoarthritis (OA) is a degenerative joint disease that primarily affects the elderly worldwide. It is characterized by local inflammation, which can be targeted therapeutically using natural anti-inflammatory compounds such as curcumin. This scoping review explores the therapeutic effects and mechanisms of curcumin in OA management. A total of 50 relevant original studies published in English were selected from PubMed, Web of Science, and Scopus using specific search strings, regardless of study type. These studies demonstrated curcumin’s anti-inflammatory, protective, and anti-apoptotic effects on chondrocytes. Curcumin has been shown to stimulate chondrocyte proliferation and collagen production while inhibiting matrix metalloproteinase activity. These mechanisms contribute to curcumin's ability to alleviate pain and improve joint function in OA patients. While the findings highlight curcumin’s potential in OA management, further research is needed to enhance its bioavailability and determine optimal formulations, dosages, and administration routes.
Person Deixis as a Communicative Tool in Medical Consultations
Authors: Many Daniel , Fogarasi Katalin , Torzsa Péter
Published: December 2024

This study investigates the role of person deixis in enhancing doctor-patient communication. Person deixis, which involves linguistic expressions linking utterances to personal referents, is crucial in shaping the dynamics of medical consultations. Drawing on Functional Pragmatics, this research emphasizes the importance of context and communicative functions in language use. A mixed-method approach was employed, combining quantitative and qualitative analyses of a Hungarian corpus comprising 50 recorded consultations between six general practitioners and their patients. Quantitative analysis revealed that third-person singular verbs, used formally to address patients, are the most frequent type of person deixis, accounting for 37.4% of occurrences. First-person singular verbs (13.9%) and first-person plural verbs (7.4%) also play important roles in conveying personal perspectives and fostering collaboration. Personal pronouns and nouns with possessive suffixes further personalize interactions, emphasizing the patient's active role. Qualitative analysis highlighted how deictic expressions construct identities, and moderate relational dynamics. The use of third-person singular verbs reflects a formal and respectful tone, maintaining professional distance. In contrast, first-person singular and plural verbs enhance patient engagement and collaborative decision-making, fostering a sense of partnership and empathy. The findings demonstrate a communication style that balances formality and respect with active participation and collaboration. Understanding these patterns can inform best practices for enhancing healthcare communication, ultimately improving patient outcomes and satisfaction.
Students’ voice in essayist prose: A longitudinal and emic approach to positioning
Authors: Ávila Reyes Natalia , Léniz Estrella , Lagos Javiera , Figueroa Miralles Javiera
Published: December 2024

The acquisition of academic writing poses challenges for students, who are often provided with little guidance. This article aims to analyze student writing in the early years of university education with a longitudinal perspective, focusing on a student genre – the essay – that is ubiquitous in academia, but roughly defined and rarely problematized. An emic approach, complemented with quantifications of usage, is used to address the emergence of discursive resources of positioning that contribute to the construction of voice in academic writing. A sample of eight students enrolled in social sciences and humanities programs at a Chilean university who participated in a three-year study was selected, to analyze the emergence of voice and positioning while contributing to the description of metadiscourse in Spanish. The results show that almost all uses of metadiscourse increase or become more sophisticated over time, but few do so in a statistically significant way. In addition, participants adhere to simplified views about academic writing, which lead them to believe that positioning should be avoided. Consequently, tensions emerge between the desire to express their voice and to meet the expectations of essayist prose. The findings offer clues about the potential of teaching metadiscourse to develop a metalinguistic mastery of resources and promote greater agency and the expression of voice in academic writing.
Sustainability in The Translation Classroom: Awareness Through Transformative Practical Activities
Authors: Alcalde Peñalver Elena , Santamaría Urbieta Alexandra
Published: December 2024

Environmental sustainability is a topic that has gained increasing importance in recent years and is indeed part of the objectives set by the United Nations as part of the Agenda 2030. This has also become evident in the field of translation, as documents such as companies' sustainability reports have emerged, which need to be available to investors in different languages. There is a lack of information regarding previous investigations into the potential benefits of incorporating environmental sustainability themes into university-level translation studies. Whether such an approach can effectively raise student awareness and understanding of critical environmental issues remains unclear. Therefore, this study, grounded in English for Specific Purposes (ESP) principles, is based on a didactic experience in which a questionnaire is distributed among students enrolled in a Financial Translation course. The aim is to understand their perception of how a translation activity within the ESP context can promote specific knowledge about a subject and raise awareness about it. The results show that, indeed, translation can become a transformative practice for students to acquire specific knowledge and form their own opinion on current topics such as sustainability. This study contributes to the literature on ESP by highlighting the potential of translation as a tool for developing language proficiency, subject-specific knowledge, and critical thinking skills within a specialized domain.
Lexical Semantics for Terminology: An introduction, by Marie-Claude L’Homme
Authors: Feng Haoda , Xu Hongying
Published: December 2024

The Terminology and Lexicography Research and Practice series by John Benjamins aims to offer readers in-depth studies that report on recent advances in the area of terminology and lexicography. The works collected for this book series cover a wide range of cutting-edge topics such as dynamics of terminologies (see e.g. Kageura, 2012) and terminological variation (see e.g. Daille, 2017), featuring a number of research methodologies such as philosophical, computational and cognitive approaches. Marie-Claude L’Homme’s book entitled Lexical Semantics for Terminology: An introduction in this series is very interesting, because it clarifies the interplay between lexical semantics and terminology, specifically including meaning and concept, term identification, polysemy, equivalence in terminology and so forth. In particular, this monograph highlights the robustness of corpus approaches and elucidates for readers how corpus data can be used to help facilitate quantitative and qualitative analyses within various lexico-semantic models, all of which is an innovative step towards the complement to knowledge-driven approaches. Therefore, the book under review would appeal to a broad spectrum of readership including terminologists, lexicographers, trainee and professional translators, corpus linguists, language researchers, and particularly those who show an interest in studies involving specialised terms.
The effect of plant and fungal beta-glucan on the rheology of teff dough and the quality of bakery products
Authors:   ITMO University, Yimer Getnet A. , Frioui Mohamed ,   Saint-Petersburg State Institute of Technology, Barakova Nadezhda V. ,   ITMO University, Shamtsyan Mark M. ,   Saint-Petersburg State Institute of Technology, Maytakov Anatoly L. ,   Kemerovo State University, Baskovtceva Angelina S. ,   ITMO University, Dozortseva Alexandra K. ,   Saint-Petersburg State Institute of Technology
Published: December 2024

Functional and technological properties of teff flour, as well as plant-based and fungal β-glucans, were determined. The experiments used teff flour obtained from grains grown in Ethiopia (harvest of 2023); PromOat oat β-glucan produced by Lantmannen Oats in Sweden, with a β-glucan content of 32.0 ±0.2% on a dry basis, and fungal β-glucan extracted from Pleurotus ostreatus, with a β-glucan content of 31.2 ±0.1% on a dry basis. Water-binding capacity (WBC) was compared according to the standard method AACC 88-04, water-holding capacity (WHC) – according to the Inglett method. A rota-ry viscometer was used to analyse the viscosity of the dough, the amount of carbon dioxide released during dough fermen-tation was measured on a rheofermentometer. It was found that the WBC of fungal β-glucan is 2.5 ±0.06 g/g, while the WBC of oat β-glucan is 2.0 ±0.06 g/g; the WHC of oat β-glucan is 1.5 ±0.01 g/g, and the WHC of fungal β-glucan is 2.0 ±0.01 g/g; the WBC of teff flour is 2.0 ±0.01 g/g. It was also established that the coefficient of dynamic viscosity of doughs made from teff flour and fungal β-glucan is higher than that of doughs made from teff flour and oat β-glucan. Compared to oat β-glucan, the higher WBC of fungal β-glucan and its ability to form more viscous doughs with teff flour will require greater effort when preparing the dough. The higher WHC of fungal β-glucan will contribute to preserving freshness in baked products made with fungal β-glucan. The analysis of the gas-producing capacity of dough made from teff flour with the addition of fungal and oat β-glucans showed that the fermentation process in the dough with oat β-glucan ends 17 minutes after the start of fermentation. In contrast, the dough with fungal β-glucan ends after 43 minutes. Based on the results obtained during the experiments, it can be concluded that fungal β-glucans should be added to confectionery prod-ucts, while oat β-glucans should be added to baked goods made with microorganisms, in this case, yeast. The results ob-tained are useful for developing gluten-free products by adding plant-based and fungal β-glucans.
Baking and rheological properties of alternative flour types
Authors:   ITMO University, Korovyansky Vyacheslav S. , Novichenko Alexander A. ,   ITMO University, Ivanova Vera A. ,   ITMO University, Gur’ev Sergey S. ,   ITMO University, Kondratev Mikhail A. ,   ITMO University, Gud Vladislav A. ,   ITMO University
Published: December 2024

The baking properties of green buckwheat, lentil, corn, coconut, amaranth, and brown rice flours as well their effect on the rheological properties of dough semifinished products made from wheat flour were investigated. For the study, high-grade wheat flour as well as mixtures of high-grade wheat flour and the flours under investigation (5; 10; 15; 20; and 25% replacement) were taken. The breadmaking properties of the flour types were tested at 5, 15, and 25% replacement. Rheo-logical properties were determined using farinograph (Brabender), alveograph (Chopin), amylograph (Brabender), and falling number measurement device (Perten). It was found that amaranth flour had the greatest effect on the water absorp-tion capacity of the flour mixture, with its increase by 13.3% when replacing wheat flour at a 25% ratio. To evaluate the baking properties of the studied flour types, an analysis on their influence on the volume of finished products, sensory characteristics of bread, and change of bread softness during storage was conducted with the use of a texture analyzer (TA.XTplus100C). When 10% coconut flour was added to the dough, its kneading stability increased significantly, reach-ing 48 minutes 49 seconds. Alveographic tests demonstrated a decrease in the baking power of the dough semifinished products in all samples, with the corn flour sample showing the smallest decrease of 35.2% and the lentil flour sample showing the largest decrease of 75.4%. Based on the studies conducted, the amylograms of the flour mixtures showed the highest increase of 486 units in the gelatinization maximum in the sample containing corn flour at 25% dosage. Replac-ing wheat flour with coconut flour, corn flour, and hydrothermally unprocessed buckwheat flour reduced the specific vol-ume of bread. The most pronounced decrease in specific volume was observed when replacing with coconut flour, by 0.6 cm3/g at 25% replacement. The optimum ratio of dough rheological properties and baking quality was achieved in the mix-ture of high-grade wheat flour with 25% amaranth flour.
Effects of a News Literacy Video on News Literacy Perceptions and Misinformation Evaluation
Authors: Tang Rita , Tully Melissa , Bode Leticia , Vraga Emily K.
Published: December 2024

The mixing of misinformation with high-quality news and information on social media has reinvigorated interest in the value of news literacy (NL) to build audience resiliency to misinformation. Optimizing NL messages for social media environments—where they may be seen alongside misinformation—allows these messages to reach audiences when they are most likely to benefit from them. Using a 2 (NL video vs. control video) x 2 (sunscreen promotion video vs. sunscreen misinformation video) online survey experiment (N = 780), we examine whether exposure to an NL video improves perceived personal NL skills and value for news literacy, as well as enables participants to recognize and avoid engaging with misinformation. Our findings suggest that after watching the NL video, individuals valued NL more but their self-perceived news literacy did not improve. Furthermore, watching the NL video made individuals rate the second video as less credible and reduced engagement with it no matter whether the second video contained misinformation or quality information. This research has several important implications. While watching an NL video could protect individuals by discrediting and decreasing engagement with misinformation, it may do so at the expense of high-quality information. We discuss the difficulty in designing NL messages that lead people to be appropriately skeptical and able to discern between high- and low-quality health information, rather than cynically disengaging with media content altogether.
The role of ARID1A in malignant neoplasms of the female reproductive system: a modern view on diagnostic and therapeutic opportunities
Authors: Marzaganova A. I. , Martirosyan I. R. , Korchemkina A. S. , Avanesyan E. G. , Korkmazova D. A. , Grakhnova O. B. , Akimina V. V. , Dzhamalutdinova A. P. , Bolloev D. A. , Dugulbgova A. M. , Bakhmudova Z. G. , Salikhova A. T. , Dzigora P. A.
Published: December 2024

Сhromatin remodeling tumor suppressor protein ARID1A (AT-rich interaction domain 1A) is coded by the ARID1A gene as one of the most frequently mutated genes in human oncological diseases. Inactivating mutations in the ARID1A gene have a pronounced effect on cell survival, chemoresistance, transcription and cell cycle regulation. To date, a large number of studies have focused on assessing the effect of mutations leading to loss of ARID1A function on tumor emergence, progression and therapy resistance. The high frequency of ARID1A mutations in malignant tumors of the female reproductive system opens up unique opportunities for targeted preventive and therapeutic intervention. Clear cell ovarian carcinoma and uterine body cancer bearing ARID1A mutations do not respond well to standard chemotherapy proposing no current effective targeted therapy, which underlines a need for further research in the field. ARID1A can be used as a biomarker of precancerous diseases, as well as as a tool for predicting а response to radiation therapy, immunotherapy and targeted therapies. Currently, clinical trials assessing several low molecular weight and epigenetic inhibitors are being conducted in tumors of the female reproductive system with ARID1A deficiency.
Abandono y transferencia: un análisis desde la satisfacción académica en estudiantes de Educación
Authors: Blanco González Elena , Tuero Herrero Ellián , Casanova Joana , Bernardo Gutiérrez Ana Belén
Published: December 2024

Para obtener un acercamiento global al abandono universitario es esencial desarrollar investigaciones centradas tanto en la transferencia (cambio de titulación y/o universidad) como en el abandono definitivo. Hasta la fecha, han aumentado el número de estudios que ahondan en las causas de este último, siendo escasos aquellos que abordan la transferencia como otra forma de abandono con graves consecuencias y altas tasas. El presente estudio busca analizar la intención de abandono, tomando en consideración la intención de transferencia y de abandono definitivo; y analiza la satisfacción, una variable con gran valor predictivo sobre el abandono, en función de dicha intención de abandono. Para ello se cuenta con 402 estudiantes de educación de una universidad española. Los resultados reflejan un 11,4% de intención de transferencia y un 11,2% de intención de abandono. Asimismo, se observan diferencias estadísticamente significativas entre los tres grupos, siendo el alumnado con intención de permanencia el que presenta una mayor satisfacción académica, seguido por aquel con intención de abandono y, en último lugar, el alumnado con intención de transferencia. Estos hallazgos manifiestan la importancia de la transferencia y la necesidad de llevar a cabo estudios comparativos para perfilar las variables relevantes en ambos tipos de abandono.