bluuebunny/crossref_metadata_2025 huggingface dataset:
Suspending the Embodied Self in Meditation Attenuates Beta Oscillations in the Posterior Medial Cortex
Authors: Trautwein Fynn-Mathis , Schweitzer Yoav , Dor-Ziderman Yair , Nave Ohad , Ataria Yochai , Fulder Stephen , Berkovich-Ohana Aviva
Published: May 2024

Human experience is imbued by the sense of being an embodied agent. The investigation of such basic self-consciousness has been hampered by the difficulty of comprehensively modulating it in the laboratory while reliably capturing ensuing subjective changes. The present preregistered study fills this gap by combining advanced meditative states with principled phenomenological interviews: 46 long-term meditators (19 female, 27 male) were instructed to modulate and attenuate their embodied self-experience during magnetoencephalographic monitoring. Results showed frequency-specific (high-beta band) activity reductions in frontoparietal and posterior medial cortices (PMC). Importantly, PMC reductions were driven by a subgroup describing radical embodied self-disruptions, including suspension of agency and dissolution of a localized first-person perspective. Neural changes were correlated with lifetime meditation and interview-derived experiential changes, but not with classical self-reports. The results demonstrate the potential of integrating in-depth first–person methods into neuroscientific experiments. Furthermore, they highlight neural oscillations in the PMC as a central process supporting the embodied sense of self.
Black Latina Passages through Colonial Ecologies of Illness and the Art of Composting Aesthetics
Authors: Ramirez Geovani
Published: May 2024

Drawing from Black Latinx and feminist thought to place Latinx Studies and medical/health humanities in conversation, this project asks, what are the medical and colonial histories, personal and collective, that inform patients’ perceptions of illness and Western biomedicine? What happens in cases when Latinx patients have internalized historical forms of medical violence, and what are the means by which Latinx patients construct their healing through narrative? These questions are grounded in material conditions with special concerns for the well-being of Latinx patients, but they are explored via a historically and culturally informed literary analysis of Jasminne Méndez’s Night-Blooming Jasmin(n)e (Night-Blooming), a personal illness narrative composed of poems and lyrical essays that portrays, among other health conditions, Méndez’s life with Scleroderma, Lupus, and Raynaud’s disease. Offering a close reading of Night-Blooming’s biomedical critiques alongside the ecological language, metaphors, and formal structure she employs to describe her illness, the author argues that narratives such as Night-Blooming require us to travel into the colonial ecologies of illness, environmental characteristics, practices, and rhetoric in medical settings that evoke colonial encounters from within and beyond the strict boundaries of healthcare facilities. This essay also follows in the passages of Méndez’s figurative travels to the island of Hispaniola as she works to recover her language, health, and Black roots. Acknowledging the ways Méndez’s chronic illness and biomedicine distort her (textual) body, psychiatric health, and language becomes necessary to appreciate Méndez’s composting aesthetics of illness, healing work that involves a struggle to recover that which is painful and deteriorating for life-affirming and life-sustaining purposes. I suggest that by enacting an aestheticization of illness alongside experiences of pain, Méndez uses Night-Blooming as a conduit to theorize about the potential for transforming human suffering from chronic illness into a means toward cultivating life.
GÜVENLİK SORUŞTURMASI VE ARŞİV ARAŞTIRMASI UYGULAMASINA ELEŞTİREL BİR BAKIŞ VE BAZI ÖNERİLER
Authors: Aydın Muhammed Ali
Published: May 2024

7315 sayılı Güvenlik Soruşturması ve Arşiv Araştırması Kanunu kapsamında uygulanan güvenlik soruşturması ve arşiv araştırması kamu görevine ataması yapılacak kişiler açısından mağduriyetlere yol açabilecek niteliktedir. Mağduriyetlere yol açabilecek uygulamalara söz konusu Kanun’un şeffaflık, bilgi edinme imkanı, nesnellik ve etkin itiraz ve başvuru yolları içermeyen sistemi sebep olmaktadır. Kamu görevlerine Anayasal düzene bağlı olmayan, terör örgütleriyle ilişkisi veya irtibatı bulunan kişilerin atanmasının kamu yararına uygun olmadığı açıktır. Ancak bir kişi hakkındaki olumsuz değerlendirmelerin somut verilere dayanması, keyfi ve sübjektif olmaması gerekir. İlgili kişinin ise hakkındaki raporda yer alan bilgi, fiil isnadı ve değerlendirmeleri inceleyebilmesi, isteği halinde izah getirebilmesi imkanına sahip olması ve son çare olarak etkin bir yargısal başvuru hakkına sahip olması gerekir. Bu çalışmada öncelikle Güvenlik Soruşturması ve Arşiv Araştırması Kanunu incelenmiş, sonrasında da uygulamayı iyileştirmeye yönelik önerilerde bulunulmuştur. Güvenlik soruşturması ve arşiv araştırmasının hukuk devleti standartlarında yürütülmesi için değerlendirmelerde bulunulmuştur.
Resampling methods in survey sampling
Authors: Krapavickaitė Danutė , Šalučkienė Genovaitė
Published: May 2024

Aim of this paper is to estimate variances of the estimates of the population totals using re­sampling methods and to compare them with the known variances of the estimates.
The modelling by finite elements of plane junction zones in heat transfer problems
Authors: Turskienė Sigita
Published: May 2024

The paper deals with the temperature field analysis problem of the junction zone of the thin-­walled branched structures plates, which is important for the investigation of thermal stress con­centration zones.
Dimensional changes of airways observed in lateral radiographs of patients undergoing orthognathic surgery at the carlos Ardila Lulle clinic from 2010 to 2016
Authors: María Alejandra Mantilla Pico , Jazmín Rubiela Ruiz Solano , Geimy Fallad Perez
Published: May 2024

Introduction: Skeletal alterations are variations that occur in the jaws and occlusion. In addition, these can generate problems in the pharyngeal airways. For this reason, different procedures arise to correct bony problems, such as orthognathic surgery. However, these surgical techniques do not fully prove significant changes in the upper and lower pharyngeal airways. Objectives: To determine the anteroposterior dimensional changes of the upper and lower pharyngeal airways in lateral skull radiographs of patients undergoing orthognathic surgery. Methodology: A descriptive observational study was carried out. Cross-sectional. The sample included 24 lateral cephalic radiographs of patients between 18 and 60 years of age who underwent orthognathic surgery. Proportions were calculated for qualitative variables and measures of central tendency and dispersion for quantitative variables. For cephalometric variables before versus after; the paired Student's t-test or the Wilcoxon sign test was applied according to the distribution of the data, additionally the Pearson correlation coefficient was applied to relate the dimensional changes of the pharyngeal airways with the SNA and SNB planes. A significance level of α ≤ 0.05 was considered for the analysis. Results: It is important to highlight that for maxillary retrocession surgery there were statistically significant differences before and after the surgical process (p=0.0023) since thanks to this surgery the patients had 1.7 mm more in their upper pharyngeal space. While the forward and also the mandibular backward surgeries allowed them to gain 1.5 (p=0.0108) and 1.8 mm (p=0.0184) in this same pharyngeal space. Conclusion: Twenty-four lateral skull radiographs were evaluated, in which it was possible to determine changes in the amplitude of the upper and lower pharyngeal airways, which could have been produced by the set of surgical procedures to which each of the patients underwent.
Occupational therapy and chronic pain - the didactic experience at academic pain league at the University of São Paulo medical school
Authors: Bense Othero PhD Marilia , Silva Gabriela Zeoti , Ferreira Jheniffer Gonzaga , Viana Leticia Rodrigues , Passe Samanta Della , Taricani Kubota MD Gabriel , Jacobsen Teixeira hD Manoel
Published: May 2024

Occupational Therapy interventions for people with chronic pain focus on promoting independence/autonomy and rescuing meaningful activities (interrupted after the limitations brought about by illness). Various strategies can be used, such as: guidance on energy conservation and joint protection techniques, prescription and/or manufacture of positioning devices, prescription and/or manufacture of assistive technology equipment, development of creative and expressive activities, training activities of daily living, environmental assessment, guidance for family members and caregivers. This article aims to present the implementation of the Occupational Therapy Service at the FMUSP Pain League, developed since 2023. The work focused on implementing Occupational Therapy as one of the professions that make up the FMUSP Pain League, on a permanent and continuous basis; and, in addition, allow undergraduates teaching opportunities (theoretical and practical) related to the multidisciplinary care of people with chronic pain, as well as promoting research actions in the area of ​​Occupational Therapy and Chronic Pain. In OT, a student and the supervising teacher work, together with the multidisciplinary team. Activities are weekly and take place at night. Remote and in-service supervision is carried out. The implementation took place in 3 stages. In the first stage, we sought to understand the dynamics of the league, as well as characterize the patients and their specific demands, through participant observation. The second stage was structured around the specific OT intervention; evaluations of league users were carried out, with the application of evaluation and recording instruments. The third stage focused on monitoring patients and families, with new assessments carried out when necessary. Interventions follows through individual plan care, family guidance, development of educational material, prescription and/or production of assistive technology devices. The service uses a specific evolution form and the data feeds into a service database. We consider that the results obtained are satisfactory, as theoretical and practical learning was possible for the participating student. Currently, Occupational Therapy is already part of the League's routine activities, with participation in the Introductory Course, in the Board of Directors and in planning activities for 2024.
Project management: hybrid approach for construction projects
Authors: Frangakis Cano Yaiseth
Published: May 2024

This research aims to innovate in project management by demonstrating the benefits of implementing the Hybrid Project Management Methodology in construction projects. The construction industry operates in complex environments with high levels of change, making it essential to adapt management approaches accordingly. This study reveals that integrating Agile with Traditional Project Management Methodology enhances project execution by fostering flexibility, adaptation, continuous value delivery, motivation, effective Methods communications, and constant feedback throughout the project life cycle. Consequently, this integration leads to improved project outcomes and goal achievement. Furthermore, the research highlights the growing recognition among construction professionals of the importance of adopting methodologies that enhance their project management skills, demonstrating a pressing need for such approaches in the industry. Statistical validation confirms the appropriateness of applying the Hybrid Project Management Methodology in the construction sector, with a significant result of 3.903, indicating a high level of appropriateness.
Urokinase type plasminogen activator expression and its correlation with angiogenesis and lymph node metastasis in breast cancer
Authors: Ali Afreen , Ansari Mumtaz A , Patel Sandeep , Srivastava Vivek
Published: May 2024

Background: Search for prognostic marker in breast cancer is an area of ongoing research. uPA (Urokinase like plasminogen activator) system has been well documented in cancer invasion and metastasis and extensively researched over the years in different cancers. Familial uPAR (urokinase like plasminogen activator receptor) has been shown to promote promotes angiogenesis. Objective: To detect the expression of uPA in breast cancer patients and its correlation with established prognostic markers and Vascular Endothelial Growth Factor (VEGF) expression. Methods: Histologically proven cases of early breast cancer were included in the study who had not received any neo-adjuvant therapy. The patients were characterised based on age at diagnosis, menopausal status, parity, TNM stage. Size of tumor, type of cancer, grade of tumor, tumor necrosis, lymph nodes positive (from sections taken from lymph node), lymphovascular invasion (LVI) and immunohistological details such as hormonal status (ER, PR and HER-2/neu). The expression of VEGF and uPA was done with immunohistochemistry and correlation was analysed. Results: A total 30 histologically proven early breast cancer patients were included in the study with a mean age of 49.53±9.702 years (range 30-65 years). uPA was expressed in 90% of patients with a mean uPA IRS (immunoreactive score) of 3.567±1.85.The mean VEGF immunoreactive score was 4.16. The uPA expression was significantly associated with T-stage (p<0.001), axillary node (p=0.029), grade of tumor (p=0.028) and lymphovascular invasion (p=0.002) respectively. The positive correlation was found between uPA IRS score and larger tumor size (r=0.727, p<0.001) and number of positive lymph nodes (r=0.466, p=0.009). The correlation between uPA IRS with VEGF IRS was also found to be significant positively correlated (r=0.727, p<0.001). Conclusion: The results support the importance of uPA expression in breast cancer as a potential for prognosis estimation.
Clinical description of pediatric oncology oncology patients with febrile neutropenia admitted to the intensive care unit of the national pediatric oncology unit
Authors: Gavidia Mayora Gabriela Marina , Mack Rivas Ricardo Alfredo
Published: May 2024

Objective: To describe the clinical characteristics of pediatric oncology patients who were diagnosed with Febrile Neutropenia (NF) admitted for the first time to the Intensive Care Unit (ICU) of the National Pediatric Oncology Unit (UNOP). Methods: This is a descriptive and retrospective study where a total of 211 patients who developed NF and required admission to the ICU, between the years 2017 to 2021, were characterized. Results: The average age was 8 years, 46% were male and 54% female. 72.77% had a severe level of neutropenia and leukemia (81.99%) was the prominent oncologic diagnosis. Within all treatments, 38.39% of the patients were in the induction phase. An associated infectious agent was identified in 33.18%. Gram-negative bacteria were the most frequent causative infectious agent (13.74%). The mean length of stay in the ICU was 6.75±79 days. 91.62% of patients did not require mechanical ventilation and the most frequent complication associated with NF was sepsis in 65.88% of cases. Conclusion: Most cases of Febrile Neutropenia are severe, hematological malignancies (ALL and AML) are the most frequent underlying disease for the development of NF and Gram-negative bacteria are the most frequent causative infectious agent. Most patients do not require mechanical ventilation and the most frequently associated complications are Sepsis and Pneumonia.
Relationship between serum procalcitonin values and clinical course in patients diagnosed with neonatal sepsis
Authors: López R Oscar F
Published: May 2024

Procalcitonin is considered to be one of the markers of bacterial infections in critically ill patients, as well as a diagnostic and prognostic aid in severe sepsis. Neonatal sepsis is still among the main causes of mortality among newborns worldwide. Objective: To relate serum procalcitonin values and factors such as: sex, use of vasoactive drugs, use of glucocorticoids at supra physiological doses and clinical evolution, in neonates diagnosed with sepsis. Admitted to the neonatal intensive care unit in the period between October 2018 and January 2019. Methodological design: Descriptive, retro prospective design. Results: Direct relationship was demonstrated between serum procalcitonin values >2 ng/ml, the use of both vasoactive drugs and steroids, with high mortality among the patients studied. Conclusions: Both male sex, as well as the use of the drugs reviewed significantly increase mortality when presenting procalcitonin values >10 ng/ml. An early diagnosis together with an integral treatment provides a better prognosis in newborns with sepsis in the neonatal period.
Long-term efficacy of ocrelizumab in the treatment of patients with multiple sclerosis – case reports
Authors: Krzystanek Ewa , Brola Waldemar , Wnuk Marcin
Published: May 2024

Treatment of patients with multiple sclerosis, despite the availability of many therapies, remains a challenge. The introduction of ocrelizumab, a highly effective therapy, has significantly improved the control of disease activity. The article discusses four different cases of patients treated with ocrelizumab, including one patient with newly diagnosed relapsing-remitting multiple sclerosis, one case of treatment modification after ineffective first-line therapy, and two cases of long-term follow-up of patients with primary progressive multiple sclerosis. The review of case studies is complemented by magnetic resonance images and the results of tests evaluating treatment effectiveness. In all clinical situations discussed, ocrelizumab proved to be the optimal choice. In addition to inhibiting the clinical and radiological progression of the disease in the long term, it was very well tolerated by patients.
The role of ocrelizumab in recommendations and in the Polish therapeutic programme
Authors: Kubicka Katarzyna Joanna
Published: May 2024

Multiple sclerosis is a heterogeneous and chronic disease, and the primary goal of treatment is to prevent relapses and slow the progression of disability. Ocrelizumab is a generally well-tolerated disease-modifying therapy for multiple sclerosis, with high efficacy in the treatment of active relapsing forms, and a valuable treatment method for delaying the progression of the disease in patients with the primary progressive form. The activity of relapsing multiple sclerosis is defined on the basis of the clinical course of the disease or radiological findings assessed over a year. The occurrence of clinical relapses and/or activity on magnetic resonance imaging is taken into account. In line with the recommendations of the European Committee for Treatment and Research in Multiple Sclerosis and the European Academy of Neurology, as well as in accordance with the guidelines of the American Academy of Neurology, updated in 2021, depending on the disease activity in the early stage of multiple sclerosis, the choice of a disease-modifying drug should be motivated by higher efficacy. Recommendations for the treatment of multiple sclerosis in most countries in Europe and around the world are based on the above-mentioned guidelines. In Poland, recommendations for treatment modifying the course of multiple sclerosis were developed in 2023 by experts from the Multiple Sclerosis and Neuroimmunology Section of the Polish Neurological Society. Treatment based on the B.29 drug programme of the National Health Fund in Poland allows, from 1 July 2023, in addition to escalation, using the induction model based on highly effective therapies as first-line treatment.
Ewolucja zabaw w gry. Podporządkowanie spontaniczności arbitralnym konwencjom
Authors:   Uniwersytet w Białymstoku, Jaszczyszyn Elżbieta
Published: May 2024

Among the many issues that are raised in the context of the development of preschool children, among others, there is the one devoted to the issue of play and games. However, the need to play does not cease with the end of the developmental stage that is childhood. Playing as a natural need of the species homo sapiens, along with cognitive activity (the need to learn) and social activity, are considered elementary forms of human activity also in adulthood and old age. In considering the evolution of playfulness in games, the fact of the identity of the concepts of “fun” and “play” and the possible differences in the meanings of these two concepts were emphasized. The vividness of play may be subject to discipline. The existence of a large body of literature on play (children’s, adult) sometimes relegates the analysis of the process of evolution of play activity into play (cycle: play-game). Certain categories of fun and games are very clearly arranged in a temporal sequence related to their appearance and the transition of one into another (fun into games). This issue is not one of the well-studied, but some outline of this thought can already be described.
Opór jako oznaka podmiotowej orientacji. Rozważania na marginesie pracy socjalnej
Authors:   Uniwersytet Warmińsko-Mazurski w Olsztynie, Ciczkowska-Giedziun Małgorzata
Published: May 2024

This paper attempts to analyse the concept of resistance in social work. The category of resistance is characterized by a multiplicity of meanings, which means that it is understood in many ways, depending on civilizational and cultural contexts. Reflections on the concept of resistance in the humanities and social sciences are neither simple nor straightforward, as each discipline has its own view of this category. The analyses carried out in this study are interdisciplinary, but the point of reference is social pedagogy and social work developed by it. The aim of the article is to present the achievements of the category of resistance, taking into account three ways of interpreting it: as an individual reaction of the person receiving the help, as a reaction of the person receiving the support to the relationship with the professional, as a reaction of the participants of the social welfare system to local practices, institutional and governmental policies. In the discourse of social work, it is more common to see resistance as an individual reaction and a reaction to contact with a professional, and less so as a manifestation of subjective orientation, which is a resource to reach for in the face of oppressive practices. Therefore, the article devotes special attention to this issue. The whole analysis is complemented by a reflection on the challenges faced by social work education, through which the aim is to activate the resistance competences not only of the people supported, but also of the professionals themselves. The content analysis was based on a review of Polish and foreign literature presenting the issue of resistance in relation to social work.
Study of Clinical and Demographic Profile of Scrub Typhus Patients Admitted to a Tertiary Care Hospital in Central India
Authors: Dahiphle A. V. , Achliya Amit , Chhajed Neel , Rode Vikram , Bhise Kasturi
Published: May 2024

Objectives: To study epidemiological characteristics, clinical features, laboratory findings, and clinical outcomes in cases of scrub typhus. Additionally, the study aims to identify the predictors of disease severity.Methods: This cross-sectional study was conducted in the Department of General Medicine at Dr PDM Medical College in Amaravati, India. The study duration was 6 months, from July 2023 to December 2023. All clinically confirmed patients with scrub typhus were evaluated through history, clinical examination, and appropriate laboratory investigations. The clinical and laboratory profiles, hospital course, and outcomes were analyzed. Organ dysfunction upon admission was assessed using the sequential organ failure assessment (SOFA) score.Results: A total of 200 cases were included in the study. The majority of the cases were in the age range of 31-40 years, and most of them were males. The highest number of scrub typhus cases occurred in September. The most common presenting symptoms were fever (81%), followed by nausea (37.5%), generalized weakness (34%), abdominal pain, eschar (21.5%), breathlessness, and cough (21% each), headache (19%), vomiting (15%), and altered sensorium (4.5%). The majority of patients (72.5%) did not experience any complications, while 55 patients (27.5%) developed multi-organ dysfunction syndrome (MODS) as a complication. The mortality rate was 1%.Conclusion: Scrub typhus is a significant cause of acute febrile illness in the Vidarbha region of Maharashtra. It can present with various clinical manifestations, with or without an eschar. Early diagnosis and appropriate treatment of these cases can lead to minimal complications.
Insegurança alimentar e insegurança hídrica domiciliar: um estudo de base populacional em um município da bacia hidrográfica do Rio Amazonas, Brasil
Authors: Mata Mayline Menezes da , Sanudo Adriana , Medeiros Maria Angélica Tavares de
Published: May 2024

Resumo: Este estudo analisa a insegurança alimentar e os fatores a ela associados na área urbana de um município na bacia hidrográfica do Rio Amazonas, Amazônia Ocidental. Trata-se de pesquisa transversal, de base populacional, realizada de agosto a novembro de 2021, com 983 domicílios selecionados por amostragem probabilística estratificada. Empregou-se o modelo de regressão logística multinomial, adotando-se os seguintes critérios: valor de p < 20% na análise bivariada e valor de p < 5% para o ajuste multivariado. Os resultados das análises foram descritos como odds ratios (OR) e intervalo de 95% de confiança (IC95%). Foram significantemente associadas à insegurança alimentar leve ou moderada as seguintes variáveis: insegurança hídrica domiciliar, número de moradores ≥ 5 no domicílio, pertencer à classe socioeconômica D ou E, ter pai, mãe ou outro, como chefe da família e ter algum morador beneficiário do Programa Bolsa Família. No modelo de análise para a insegurança alimentar grave constatou-se que viver em insegurança hídrica domiciliar, pertencer à classe socioeconômica D ou E, ter pai, mãe ou outro chefe da família, e tendo este menos que 55 anos, e renda familiar menor que dois salários mínimos aumentaram as chances de insegurança alimentar grave, comparativamente àqueles em segurança alimentar. Em conclusão, verificou-se alta prevalência de insegurança alimentar no Município de Itapiranga, Amazonas, Região Norte do Brasil, associada à situação de vulnerabilidade social e econômica, à falta de serviços públicos e à insegurança hídrica domiciliar.
Aferindo experiências com discriminação em múltiplos grupos sociais: análise de invariância da Escala de Discriminação Explícita em estudantes universitários
Authors: Bernardo Fabiula Renilda , Bastos João L. , Reichenheim Michael
Published: May 2024

Resumo: O objetivo foi avaliar a capacidade da Escala de Discriminação Explícita (EDE) de produzir estimativas comparáveis entre grupos de gênero, cor/raça e posição socioeconômica. A análise se baseou em dados de dois estudos, realizados com estudantes de universidades públicas brasileiras. Uma versão abreviada da EDE com oito itens foi avaliada, utilizando o método alignment (alinhamento). Nossos achados indicaram violação de invariância entre grupos de cor/raça e gênero. Os relatos de experiências discriminatórias tiveram melhor comparabilidade entre estratos de posição socioeconômica. Este estudo demonstrou que a EDE deve ser utilizada com cautela, especialmente para fazer comparações de estimativas de discriminação entre respondentes de cor/raça e gênero distintos. A violação de invariância observada reforça a necessidade de pesquisas adicionais, examinando se tal cenário se mantém em amostras mais amplas e diversas do país.
‘We have arrested one of the fundamental pieces of subversion in the country’: The construction of the figure of the enemy in police memos of 1975 following the arrest of Marcos Osatinsky
Authors: Ríos Lucía
Published: May 2024

Abstract In the following article, I investigate the modes of construction of a specific subjectivity in the 1970s in Argentina: the figure of the enemy at the onset of the last civic-military dictatorship in the country. To achieve this, I focus on the arrest of Marcos Osatinsky, head of the Montoneros organisation, in Córdoba in August 1975. I analyse the how his arrest was handled by the security forces, based on police memoranda that refer to this event, available for consultation in the Archivo Provincial de la Memoria [Provincial Memory Archive]. I inquire how the Córdoba police functioned in the 1970s, and how what happened to Osatinsky was reflected in the writing practices of the police through police memos, in order to understand how the figure of the subversive was constructed in this handling of the facts.
Expertos, trabajo relacional y la producción de evidencia en torno del Plan Nacional de Primera Infancia, Argentina (2015-2019)
Authors: Landeira Florencia Paz
Published: May 2024

Resumen Este artículo se centra en las prácticas desplegadas por expertos/as en la conformación de una agenda sobre la primera infancia en Argentina, entre 2015-2019, en una coyuntura política signada por un doble cambio, de gestión de gobierno, y también de signo político del partido gobernante; como también por debates sobre el rol del Estado y de otros actores en la definición de lo público. A partir de una investigación doctoral de carácter etnográfico, los/as expertos/as fueron analizados/as como knowledge brokers, que mueven, traducen y ensamblan, saberes y agendas globales, y especialmente, redes de influencia y vínculos, por lo que sus prácticas conforman un particular trabajo relacional. La primera infancia, a su vez, apareció como un nodo crítico y polémico, que requiere de la producción de marcos interpretativos y de estrategias de persuasión, como también de la formación, sostenida en el tiempo, de alianzas y redes.
A Imigração Japonesa nas Fronteiras entre o Pensamento Social e a Política Parlamentar: A Eugenia de Pacheco e Silva e a Sociologia de Gilberto Freyre
Authors: Hayashi Bruno Naomassa
Published: May 2024

Resumo O final da Segunda Guerra Mundial marca um conjunto de grandes transformações no pensamento social brasileiro. As teorias raciais e eugênicas vão perdendo rapidamente força frente às interpretações de cunho cultural e econômico. Neste trabalho, conta-se parte dessas transformações a partir das interpretações sobre a imigração japonesa no Brasil em dois intelectuais de marcante atuação parlamentar: o psiquiatra-eugenista Pacheco e Silva e o sociólogo Gilberto Freyre. A imigração japonesa foi foco de intenso debate nas décadas de 1930 e 1940, merecendo até mesmo emendas restritivas ou proibitivas nas Constituintes de 1934 e 1946. Este estudo analisa a atuação parlamentar dos dois intelectuais nesse período, observando as influências de seus pensamentos sociais em sua atividade política. O artigo examina, ainda, as transformações que ocorrem na década de 1950, com mudanças no pensamento de Pacheco e Silva, maior influência do pensamento de Freyre e um redesenho do lugar da imigração japonesa no debate parlamentar.
Adaptation and validation of the European Cyberbullying Intervention Project Questionnaire scale in a sample of Portuguese adolescents
Authors: Monteiro Ana Paula , Fonseca Daniela , Correia Elisete
Published: May 2024

Introdução. O cyberbullying acarreta consequências negativas para os envolvidos e para o ambiente escolar, sendo importante a existência de instrumentos que ajudem a detetar e compreender este fenómeno. Objetivo. A presente investigação pretendeu traduzir e adaptar, para a população portuguesa, a escala European Cyberbullying Intervention Project Questionnaire (ECIPQ), estudando as suas propriedades psicométricas. Metodologia. Estudo de caracter quantitativo e transversal, no qual participaram no estudo 440 alunos do ensino secundário de escolas do norte e centro de Portugal. Resultado. A análise fatorial confirmatória revelou bons índices de ajustamento, permitindo confirmar o modelo fatorial do instrumento original constituído por dois fatores correlacionados entre si, designadamente a cybervítimação e a cyberagressão. Todos os fatores revelaram boa consistência interna. Conclusão. A versão portuguesa do ECIPQ apresenta boas características psicométricas, que legitimam a sua utilização na investigação e na intervenção psicopedagógica.
Polarization of M2 Tumor-Associated Macrophages (TAMs) in Cancer Immunotherapy
Authors: Bui Indy , Bonavida Benjamin
Published: May 2024

We have witnessed in the last decade new milestones in the treatment of various resistant cancers with new immunotherapeutic modalities. These advances have resulted in significant objective durable clinical responses in a subset of cancer patients. These findings strongly suggested that immunotherapy should be considered for the treatment of all subsets of cancer patients. Accordingly, the mechanisms underlying resistance to immunotherapy must be explored and develop new means to target these resistant factors. One of the pivotal resistance mechanisms in the tumor microenvironment (TME) is the high infiltration of tumor-associated macrophages (TAMs) that are highly immunosuppressive and responsible, in large part, of cancer immune evasion. Thus, various approaches have been investigated to target the TAMs to restore the anti-tumor immune response. One approach is to polarize the M2 TAMS to the M1 phenotype that participates in the activation of the anti-tumor response. In this review, we discuss the various and differential properties of the M1 and M2 phenotypes, the molecular signaling pathways that participate in the polarization, and various approaches used to target the polarization of the M2 TAMs into the M1 anti-tumor phenotype. These approaches include inhibitors of histone deacetylases, PI3K inhibitors, STAT3 inhibitors, TLR agonists, and metabolic reprogramming. Clearly, due to the distinct features of various cancers and their heterogeneities, a single approach outlined above might only be effective against some cancers and not others. In addition, targeting by itself may not be efficacious unless used in combination with other therapeutic modalities.
Geomorphological Structure of Landform Characteristics As A Reference for Development Recommendations in Active Volcanic and Faulting Areas, A Case Study in Kerinci Region, Jambi Province, Indonesia
Authors: Utama Hari Wiki , Mulyasari Rahmi
Published: May 2024

Kerinci Regency is located on the western to the southwestern part of the capital city of Jambi Province, Indonesia. It has interesting geomorphological sites consisting of the physiography of the Barisan Mountain Zone associated with the Sumatran Fault System known as a volcanic-tectonic complex. Geomorphology has an important role in providing information of the landscape in an area. This paper aims to determine the geomorphological characteristics of the area which can provide information regarding disaster mitigation, the direction of land-use innovation, and infrastructure development strategies. This research uses analyses of morphographic, morphometric, morphogenetic, morphoconservation, and morphochronological aspects. Analysis of satellite images and topographic contours is a method used to determine the characteristics of drainage patterns and geological mapping. A significant result of this research is a geomorphological map of Kerinci that divides the area into several geomorphological units, namely volcanic-denudational, karst, structural, volcanic-structural, structural-denudational, and fluvial morphologies. Based on the geomorphological map, the area has a very high potential hazard consisting of volcanic structural landforms, which are Tanco Isolated Hill (TIH), Kerinci Fault Escarpment Undulation (KFEU), Kerinci Fault Escarpment Volcanic Undulation (KFEVU), structural landforms (Alang Structural Valley (ASV), Kumun Fault Hills (KFH), and Pengasih Fault Undulation (PGFU)). This map can be used to design the Standard Operating Procedures (SOP) for regional development in Kerinci.
Karst Aquifer Characterization by Means of Its Karstification Degree and Time Series Analysis (Case: Ngerong Spring in Rengel Karst, East Java, Indonesia)
Authors: Mujib Muhammad Asyroful , Adji Tjahyo Nugroho , Haryono Eko , Naufal Muhammad , Fatchurohman Hendy
Published: May 2024

The purpose of this study is to define the characteristics of the karst aquifer, which is approximated by the parameters of (1) degree of karstification (Dk) and (2) time series analysis (cross-correlation and auto-correlation). This research focuses on the Ngerong Spring, the largest spring in Rengel Karst, East Java, Indonesia. Pendant rain gauge RG-3M and HOBO U20L-02 water-level data loggers were installed over one year with a recording interval of 15 minutes. Furthermore, after one year of time-series discharge data was obtained, the discharge recession coefficient was applied to make the recession formula. It was then used to estimate the karstification degree scale from 1 to 10. The aquifer memory system and the spring response to rainfall events were analyzed by auto-correlation and cross-correlation. The results of this study indicate that the karstification degree (Dk) of the Ngerong Spring system is 4.8-5.0, with one laminar and one turbulent flow subregime type. The aquifer system comprises a subregime with turbulent and laminar flow, where the substantial role in groundwater discharge plays the subregime with laminar flow. Meanwhile, time series analysis shows that the capacity of aquifer storage in the Ngerong Spring is large enough. It has a memory effect for 26.41 days, followed by a rapid response to rainfall events within 8 hours. Compared with several other karst sites in Java, the Ngerong Spring aquifer has the youngest development level with the best storage and the slowest release.
Reinterpretation of Salodik Group Performance Based on Facies and Diagenesis Approaches to Classify Reservoir Quality
Authors: Jambak Moeh. Ali , Ibrahim Ivan , Harnest Billy , Irano Teddy , Prabawa Gusti , Luthfi Ramadhan , Prasetyo Ardyand Budi
Published: May 2024

An integrated study of several methods to characterize a carbonate reservoir provides a comprehensive result on carbonate facies and diagenesis. Therefore, a study on the Tertiary carbonate reservoir at the East Arm of Sulawesi area, Banggai – Sula Basin, is intended to determine the Salodik Group carbonate reservoir facies and diagenesis. Moreover, the purpose of this study is to determine the intensity and implication of syn-depositional or post-depositional processes, and to provide the reservoir final properties values, such as porosity and permeability to classify the reservoir quality. The methods of the study are based on carbonate fieldwork mapping to obtain samples on distributed traverses. Further analyses are the laboratory works to determine facies and diagenesis features on a more detailed scale. This study shows several facies, dominantly classified into reefal packstone, planktonic foraminifera packstone-wackestone, large foram packstone-mudstone, skeletal packstone-wackestone, planktonic-large foraminifera packstone-wackestone, and large foraminifera-red algae packstone. The dominant diagenesis processes are cementation and dissolution. Moreover, meteoric vadose and meteoric phreatic are predominantly the main diagenesis environment of Salodik Group formations. Furthermore, the dominant diagenesis stage is Eogenetic. The post-depositional process or the diagenetic processes, provides a more significant impact on carbonate reservoir properties than the syn-depositional process as shown on lithofacies texture. However, in general, from the younger to the oldest formation of Salodik Group, this shows a decreasing trend of reservoir properties due to the dominantcementation process in the oldest formation. Overall, the reservoir quality referring to porosity value is classified as negligible to excellent. While, based on permeability data, it is classified as the tight to good reservoir.
ARTERIAL HYPERTENSION IN PATIENTS OF OLDER AGE GROUPS: CLINICAL AND PATHOGENETIC FEATURES, CHOICE OF OPTIMAL HYPOTENSIVE THERAPY
Authors: Shadieva Asya , Chernysheva Elena , Lyalyukova Elena
Published: May 2024

Arterial hypertension is one of the main risk factors for the development of complications of
diseases of the cardiovascular system, the prevalence of which increases with age. The mechanisms of
increasing blood pressure in old age are different, the most significant of them is an increase in the stiffness of
the artery wall. Isolated systolic arterial hypertension holds a distinct place in elderly and senile patients. The
treatment of hypertension in patients of older age groups is much more difficult than in young and middleaged patients, due to the more frequent development of side effects of antihypertensive therapy, as well as the
lack of sufficient studies conducted in this category of patients.
ACUTE STRANGULATED INTESTINAL OBSTRUCTION DURING PREGNANCY (CLINICAL CASE)
Authors: Tishkova Olga , Shvarev Evgeniy , Shikhragimov Magomed , Bondarev Aleksandr , Kirilin German , Serdyukov Maksim , Savelyeva Nadezhda
Published: May 2024

Acute intestinal obstruction during pregnancy is a rare but extremely dangerous surgical pathology. Despite advances in medical technologies, preoperative diagnosis of acute surgical conditions of the abdominal organs during pregnancy is still imperfect. During pregnancy the clinical picture of the disease and laboratory parameters are nonspecific and variable which causes untimely provision of care and severe complications for both the mother and the fetus. The high incidence of acute intestinal obstruction during pregnancy is due to the adhesive process caused by surgical interventions including caesarean section the rates of which continue to rise steadily. The article presents a clinical case of a patient whose pregnancy was complicated by acute adhesive intestinal obstruction caused by the adhesive process after a previous caesarean section. The authors have noted the importance and necessity of multifield cooperation, timely decision-making both at the stage of diagnostic examination and during treatment, which made it possible to avoid severe complications from both the mother and the fetus.
CUIDADO PALIATIVO NA ATENÇÃO PRIMÁRIA À SAÚDE: percepções da equipe sobre a prática interdisciplinar
Authors: Zack Bruna Tais , Toso Beatriz Rosana Gonçalves de Oliveira , Kalinke Luciana Puchalski , Machineski Gicelle Galvan
Published: May 2024

Introdução: O cuidado paliativo tem como fundamentação a interdisciplinaridade e é realizado em todos os níveis assistenciais, sendo a Atenção Primária à Saúde a organizadora e coordenadora da rede. Objetivo: Compreender as percepções sobre a prática interdisciplinar no cuidado paliativo no âmbito da Atenção Primária. Método: Pesquisa descritiva, qualitativa, com abordagem da fenomenologia social de Alfred Schütz. O campo de pesquisa foram 16 unidades de Atenção Primária de um município localizado no oeste do Paraná/BR, obtidas via cálculo amostral no software R®. Como população, foram 38 profissionais com ensino superior, entrevistados presencialmente, de novembro/2021 a março/2022, mediante uma pergunta norteadora sobre a atuação no cuidado paliativo. As entrevistas foram gravadas e transcritas, organizadas com auxílio do IRaMuteQ® e compreendidas à luz da fenomenologia. Resultados: Com idade média de 40±8 anos, formados há 13,4 anos e 8,5 anos exercendo o cargo atual, os profissionais compreendem parcialmente o que é o cuidado paliativo, pois não o relacionam a uma prática interdisciplinar. A menção de trabalho em equipe foi mais incidente pelos enfermeiros e assistentes sociais, quem declarou possuir especialização em saúde da família e quando associado às capacitações, as expectativas e a organização do processo de trabalho. Nos Motivos-porque, os profissionais normalizam a fragmentação  do processo de trabalho, bem como que suas vivências permearam as consequências imediatas da pandemia, como a falta de reuniões de equipe, que veio a agravar as já delicadas relações interdisciplinares. Nos Motivos-para, compreendeu-se, sobretudo, a importância da retomada das reuniões de equipe e ampliação das equipes multiprofissionais. Considerações finais: Possibilitou-se compreender a percepção falha quanto o cuidado paliativo como prática interdisciplinar na atenção primária, bem como as motivações em relação às experiências vivenciadas e projeções futuras, que podem fomentar a reflexão de caminhos para melhoria da partilha de saberes nesse contexto.
IMPLICAÇÕES DIETÉTICAS NO TRANSTORNO DO ESPECTRO AUTISTA
Authors: Fernandes Pinheiro Débora , Radech de Lima Kamilla
Published: May 2024

Introdução: o Transtorno do Espectro Autista (TEA) é uma disfunção neurológica que afeta o desenvolvimento de habilidades sociais, cognitivas e linguísticas. Um dos desafios enfrentados por crianças com TEA é a seletividade alimentar, o que pode resultar em deficiências nutricionais, problemas de crescimento e alterações de peso. A importância de uma alimentação adequada no manejo do TEA tem sido enfatizada por diversos autores, uma vez que uma dieta balanceada pode influenciar positivamente os sintomas e comportamentos associados ao transtorno, proporcionando uma melhor qualidade de vida aos pacientes. O acompanhamento nutricional especializado desempenha um papel fundamental nesse processo, garantindo que a dieta seja adaptada às necessidades individuais de cada criança com TEA.  Objetivo: busca-se realizar uma revisão bibliográfica para identificar as alterações alimentares frequentemente observadas em crianças e adolescentes com TEA, bem como investigar as possíveis intervenções nutricionais que podem ser adotadas. Método: trata-se de uma revisão de literatura elaborada através de buscas realizadas em diversas bases de dados, durante o período de janeiro a junho de 2023. Sendo considerados artigos científicos publicados entre os anos de 2013 e 2023, nos idiomas português e inglês.  Resultados: a pesquisa possibilitou observar um crescente número de estudos que relacionam a melhora dos sintomas do TEA com a utilização de estratégias que visam a melhora do comportamento alimentar, enfatizando a importância da continuidade pesquisas voltadas ao tema. Conclusão: conclui-se que, embora ainda não existam evidências sólidas para intervenções dietéticas específicas no TEA, é necessária a continuidade das pesquisas nessa área. Enquanto isso, o acompanhamento cuidadoso dos hábitos alimentares e o uso de abordagens baseadas em evidências, quando apropriado, podem ser recursos importantes para auxiliar no manejo nutricional de crianças com TEA.
Rough Edges of the Status of a Foreign Agent. Problems of Legislative Regulation
Authors: Grigorev Egor , Gulyaev Timur , Maximova Svetlana
Published: May 2024

The Institute of Foreign Agents has gained particular importance in modern Russian legal reality. The adoption of the new federal law contributed to the unification of the regulation of this institution, but the current legislation needs in-depth study. The article is devoted to the legal understanding of the status of a foreign agent - a domestic short story in the constitutional model of rights and freedoms. It was established that the legal regulation of the status of a foreign agent meets the constitutionally significant goals of protecting the foundations of the constitutional system, rights and freedoms, and ensuring the security of the state. The need for legislative consolidation of this institution in Russia corresponds to the evolution of public-political relations. Based on the conducted comparative legal analysis of foreign experience, the contours of the legal model for securing such status in Russia are defined, the problems of the status of a foreign agent as a subject of legal regulation are identified. The authors consider the status of persons affiliated with foreign agents, their role in relation to foreign agents. An analysis of the norms of administrative and criminal legislation regulating legal relations, which arise in violation of legal instructions established for foreign agents is carried out. Based on the results of the scientific study, practical recommendations are proposed for improving and modernizing domestic legislation on foreign agents.