bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S4 from Pharmacokinetics and Pharmacodynamics-Based Mathematical Modeling Identifies an Optimal Protocol for Metronomic Chemotherapy
Authors: Ciccolini Joseph , Barbolosi Dominique , Meille Christophe , Lombard Aurélie , Serdjebi Cindy , Giacometti Sarah , Padovani Laetitia , Pasquier Eddy , André Nicolas
Published: April 2023

Impact of treatment regimens on animal weight
Figure S2 from Pharmacokinetics and Pharmacodynamics-Based Mathematical Modeling Identifies an Optimal Protocol for Metronomic Chemotherapy
Authors: Ciccolini Joseph , Barbolosi Dominique , Meille Christophe , Lombard Aurélie , Serdjebi Cindy , Giacometti Sarah , Padovani Laetitia , Pasquier Eddy , André Nicolas
Published: April 2023

Bioluminescence of GI-ME-N-Luc+ cells
Supplement from Somatic Mutations Drive Distinct Imaging Phenotypes in Lung Cancer
Authors: Rios Velazquez Emmanuel , Parmar Chintan , Liu Ying , Coroller Thibaud P. , Cruz Gisele , Stringfield Olya , Ye Zhaoxiang , Makrigiorgos Mike , Fennessy Fiona , Mak Raymond H. , Gillies Robert , Quackenbush John , Aerts Hugo J.W.L.
Published: April 2023

Supplements with additional descriptions of datasets, feature selection, and results.
Supplementary Text from Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation
Authors: Bernichtein Sophie , Pigat Natascha , Barry Delongchamps Nicolas , Boutillon Florence , Verkarre Virginie , Camparo Philippe , Reyes-Gomez Edouard , Méjean Arnaud , Oudard Stéphane M. , Lepicard Eve M. , Viltard Mélanie , Souberbielle Jean-Claude , Friedlander Gérard , Capiod Thierry , Goffin Vincent
Published: April 2023

This file contains the legends for the 7 supplementary figures
Supplementary Figure Legends from Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine
Authors: Shi Yanxia , Steppi Albert , Cao Ye , Wang Jianan , He Max M. , Li Liren , Zhang Jinfeng
Published: April 2023

Legends for the four included supplementary figures.
Supplementary Text from Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression
Authors: Reggiani Francesca , Labanca Valentina , Mancuso Patrizia , Rabascio Cristina , Talarico Giovanna , Orecchioni Stefania , Manconi Andrea , Bertolini Francesco
Published: April 2023

Legends of supplementary figures
Supplementary Figure 1 from Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine
Authors: Shi Yanxia , Steppi Albert , Cao Ye , Wang Jianan , He Max M. , Li Liren , Zhang Jinfeng
Published: April 2023

A flowchart summarizing the data analysis methodology.
Supplementary Table from Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression
Authors: Reggiani Francesca , Labanca Valentina , Mancuso Patrizia , Rabascio Cristina , Talarico Giovanna , Orecchioni Stefania , Manconi Andrea , Bertolini Francesco
Published: April 2023

Flow cytometry markers used in the investigation of human and murine cells
Supplementary Figure 1 from Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression
Authors: Reggiani Francesca , Labanca Valentina , Mancuso Patrizia , Rabascio Cristina , Talarico Giovanna , Orecchioni Stefania , Manconi Andrea , Bertolini Francesco
Published: April 2023

Additional experiments supporting cell co-culturing findings
Supplementary Table 1 from A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis
Authors: Seong Bo Kyung A. , Fathers Kelly E. , Hallett Robin , Yung Christina K. , Stein Lincoln D. , Mouaaz Samar , Kee Lynn , Hawkins Cynthia E. , Irwin Meredith S. , Kaplan David R.
Published: April 2023

Supplementary Table 1 - Summary of metastatic lesions in mice injected with the parental and enhanced metastatic subpopulations of SK-N-AS-TR.
Supplementary Fig. 4 from Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression
Authors: Reggiani Francesca , Labanca Valentina , Mancuso Patrizia , Rabascio Cristina , Talarico Giovanna , Orecchioni Stefania , Manconi Andrea , Bertolini Francesco
Published: April 2023

Additional results from obese syngeneic models
Supplementary Figures from A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis
Authors: Seong Bo Kyung A. , Fathers Kelly E. , Hallett Robin , Yung Christina K. , Stein Lincoln D. , Mouaaz Samar , Kee Lynn , Hawkins Cynthia E. , Irwin Meredith S. , Kaplan David R.
Published: April 2023

Supplementary Figure 1 - The metastatic subpopulations display enhanced metastatic burden relative to the SK-N-AS-TR parental cell line in vivo and increased chemoresistance in vitro. Supplementary Figure 2 - GSEA enrichment map show signaling pathways that are differentially regulated between parental and metastatic subtype. Supplementary Figure 3 - Genes identified in enhanced metastatic subpopulations predict survival of human NB patients in multiple datasets. Supplementary Figure 4 - CADM1 over-expression decreases migration of SHEP cell line. Supplementary Figure 5 - Verteporfin (VP), a pharmacological inhibitor of YAP, induces apoptosis and decreases migration of metastatic cells in in vitro and inhibits the metastatic phenotype in vivo. Supplementary Figure 6 - Pharmacologic inhibition of SPHK1 decreases the viability of NB cell lines and STAT3 and NFkB signaling in the enhanced metastatic subpopulations. Supplementary Figure 7 - Metastatic signature (MET-75) predicts poor survival in MYCN non-amplified patients and outperforms randomly generated 75-gene signatures.
Supplementary Figure legends from Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas
Authors: Dongre Anushka , Rashidian Mohammad , Reinhardt Ferenc , Bagnato Aaron , Keckesova Zuzana , Ploegh Hidde L. , Weinberg Robert A.
Published: April 2023

Supplementary Figure legends shows legends for each figure
Video S1, Related to Figure 2 from RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers
Authors: Irshad Sheeba , Flores-Borja Fabian , Lawler Katherine , Monypenny James , Evans Rachel , Male Victoria , Gordon Peter , Cheung Anthony , Gazinska Patrycja , Noor Farzana , Wong Felix , Grigoriadis Anita , Fruhwirth Gilbert O. , Barber Paul R. , Woodman Natalie , Patel Dominic , Rodriguez-Justo Manuel , Owen Julie , Martin Stewart G. , Pinder Sarah E. , Gillett Cheryl E. , Poland Simon P. , Ameer-Beg Simon , McCaughan Frank , Carlin Leo M. , Hasan Uzma , Withers David R. , Lane Peter , Vojnovic Borivoj , Quezada Sergio A. , Ellis Paul , Tutt Andrew N.J. , Ng Tony
Published: April 2023

Time lapse microscopy experiment of sorted NKp46-ILC3 cells (CD3-, CD11c-, B220, NKp46-, CD127+, CD90.2+) co-cultured with MSC cells as described in Figure 2B. Low magnification (Ã-10) video shows the general clustering pattern of NKp46-ILC3 cells around the MSC cells over a duration of 10 hours.
Supplementary Figures legends from RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers
Authors: Irshad Sheeba , Flores-Borja Fabian , Lawler Katherine , Monypenny James , Evans Rachel , Male Victoria , Gordon Peter , Cheung Anthony , Gazinska Patrycja , Noor Farzana , Wong Felix , Grigoriadis Anita , Fruhwirth Gilbert O. , Barber Paul R. , Woodman Natalie , Patel Dominic , Rodriguez-Justo Manuel , Owen Julie , Martin Stewart G. , Pinder Sarah E. , Gillett Cheryl E. , Poland Simon P. , Ameer-Beg Simon , McCaughan Frank , Carlin Leo M. , Hasan Uzma , Withers David R. , Lane Peter , Vojnovic Borivoj , Quezada Sergio A. , Ellis Paul , Tutt Andrew N.J. , Ng Tony
Published: April 2023

Supplementary Figure legends
Supplementary Figure 2 from PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer
Authors: Cox Orla T. , Edmunds Shelley J. , Simon-Keller Katja , Li Bo , Moran Bruce , Buckley Niamh E. , Bustamante-Garrido Milan , Healy Nollaig , O'Flanagan Ciara H. , Gallagher William M. , Kennedy Richard D. , Bernards René , Caldas Carlos , Chin Suet-Feung , Marx Alexander , O'Connor Rosemary
Published: April 2023

Related to Figure 2: Shows data for distribution of IHC scores of PDLIM2 staining in TNBC tissues and examples of PDLIM2 IHC images of normal tissue. Includes Kaplan Meier curves and clinicopathological analysis of RATHER cohorts in relation to PDLIM2 expression.
Suppl Figure 4 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC
Authors: Leonard Brandon , Brand Toni M. , O'Keefe Rachel A. , Lee Eliot D. , Zeng Yan , Kemmer Jacquelyn D. , Li Hua , Grandis Jennifer R. , Bhola Neil E.
Published: April 2023

Assessment of membranous EGFR expression in PECAPJ49 parental and CTXR#4 treated with and without cetuximab
Suppl Figure 2 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC
Authors: Leonard Brandon , Brand Toni M. , O'Keefe Rachel A. , Lee Eliot D. , Zeng Yan , Kemmer Jacquelyn D. , Li Hua , Grandis Jennifer R. , Bhola Neil E.
Published: April 2023

Response and RTK expression of acquired cetuximab resistant HNSCC models
Suppl Figure 1 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC
Authors: Leonard Brandon , Brand Toni M. , O'Keefe Rachel A. , Lee Eliot D. , Zeng Yan , Kemmer Jacquelyn D. , Li Hua , Grandis Jennifer R. , Bhola Neil E.
Published: April 2023

Schematic representing the generation of acquired cetuximab resistant HNSCC models
Figure S3 from The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation
Authors: Weissmann Simon , Cloos Paul A. , Sidoli Simone , Jensen Ole N. , Pollard Steven , Helin Kristian
Published: April 2023

Supplementary Figure S3 shows overlaps of CIC peaks and global changes in histone acetylation in G144 cells as well as changes of histone acetylation of selected targets in mESCs
Supplementary Tables from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway
Authors: Salem Mohamed , O'Brien Jacob A. , Bernaudo Stefanie , Shawer Heba , Ye Gang , Brkić Jelena , Amleh Asma , Vanderhyden Barbara C. , Refky Basel , Yang Burton B. , Krylov Sergey N. , Peng Chun
Published: April 2023

Table S1 to S3. Description of clinical samples; sequences of primers, siRNAs, and microRNA mimics and inhibitors; and analysis of top regulated genes by mir-590.
Figure S5 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway
Authors: Salem Mohamed , O'Brien Jacob A. , Bernaudo Stefanie , Shawer Heba , Ye Gang , Brkić Jelena , Amleh Asma , Vanderhyden Barbara C. , Refky Basel , Yang Burton B. , Krylov Sergey N. , Peng Chun
Published: April 2023

Relationship between FOXA2 and VCAN methylation status and their mRNA levels in the TCGA ovarian tumour samples
Figure S4 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway
Authors: Salem Mohamed , O'Brien Jacob A. , Bernaudo Stefanie , Shawer Heba , Ye Gang , Brkić Jelena , Amleh Asma , Vanderhyden Barbara C. , Refky Basel , Yang Burton B. , Krylov Sergey N. , Peng Chun
Published: April 2023

Grouping of tumour samples in TCGA ovarian cancer database for the analysis of FOXA2 and VCAN expression
Supplementary Tables S1 and S2 from Specific Targeting of MTAP-Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine
Authors: Tang Baiqing , Lee Hyung-Ok , An Serim S. , Cai Kathy Q. , Kruger Warren D.
Published: April 2023

IC50 concentrations for 6TG, 6TG+MTA, 2FA, and 2FA+MTA.
Supplementary data from Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547
Authors: Kas Sjors M. , de Ruiter Julian R. , Schipper Koen , Schut Eva , Bombardelli Lorenzo , Wientjens Ellen , Drenth Anne Paulien , de Korte-Grimmerink Renske , Mahakena Sunny , Phillips Christopher , Smith Paul D. , Klarenbeek Sjoerd , van de Wetering Koen , Berns Anton , Wessels Lodewyk F.A. , Jonkers Jos
Published: April 2023

This file describes Supplementary experimental details regarding the cell viability, clonogenic and competition assays, preparation of membrane vesicles and vesicular transport assays, immunohistochemistry, immunoblotting, RNA sequencing and analysis, amplification of SB transposon insertions and analysis, validation of the Fgfr2-Tbc1d1 fusion, Met qPCR copy number analysis and statistical analysis.
Figure S3 from Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma
Authors: Baird Jason R. , Bell R. Bryan , Troesch Victoria , Friedman David , Bambina Shelly , Kramer Gwen , Blair Tiffany C. , Medler Terry , Wu Yaping , Sun Zhaoyu , de Gruijl Tanja D. , van de Ven Rieneke , Leidner Rom S. , Crittenden Marka R. , Gough Michael J.
Published: April 2023

Single color immunofluorescence from multiplex images
Supplementary table 5 from A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells
Authors: Koifman Gabriela , Shetzer Yoav , Eizenberger Shay , Solomon Hilla , Rotkopf Ron , Molchadsky Alina , Lonetto Giuseppe , Goldfinger Naomi , Rotter Varda
Published: April 2023

IPA analysis of the differential genes between p53 Mut MSC TL and KO MSC TL sub-clones. Biological functions and pathway analysis were determined for the upregulated and downregulated genes following p53 Mut KO. (The threshold of significant genes; padj<0.05, -2>FC>2, max reads>10)
Figure S2 from TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3
Authors: Sang Youzhou , Li Yanxin , Song Lina , Alvarez Angel A. , Zhang Weiwei , Lv Deguan , Tang Jianming , Liu Feng , Chang Zhijie , Hatakeyama Shigetsugu , Hu Bo , Cheng Shi-Yuan , Feng Haizhong
Published: April 2023

Correlation assays of expression TRIM59 with SOX9 and EGFR with SOX9
Supplementary table 3 from A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells
Authors: Koifman Gabriela , Shetzer Yoav , Eizenberger Shay , Solomon Hilla , Rotkopf Ron , Molchadsky Alina , Lonetto Giuseppe , Goldfinger Naomi , Rotter Varda
Published: April 2023

IPA analysis of the differential genes between pMSCs and their derived TLs (MSC TLs). Biological function was determined for the genes that were downregulated in p53 Mut MSC TLs compared to their parental, p53 Mut pMSC. Biological function, Pathways, upstream regulators and networks were determined for the genes that were upregulated in p53 Mut MSC TLs compared to their parental. (The threshold of significant genes; padj<0.05, -2>FC>2, max reads>10)
Supplement Information figures and tables from A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells
Authors: Koifman Gabriela , Shetzer Yoav , Eizenberger Shay , Solomon Hilla , Rotkopf Ron , Molchadsky Alina , Lonetto Giuseppe , Goldfinger Naomi , Rotter Varda
Published: April 2023

Supplementary Figure 1. Mutant p53 enhanced the self-renewal capacity and oncogenicity of primary bone marrow MSCs. Supplementary Figure 2. Mutant p53 MSC derived tumor lines exhibited augmented tumorigenic capacity compared with their parental cells. Supplementary Figure 3. Transcriptional differences between pMSCs and their derived MSC TLs. Supplementary Figure 4. Knocking out mutant p53, by CRISPR gene editing system, in a MSC TL led to a reduction in tumor vascularization. Supplementary Figure 5. p53 Mut MSC TL sub-clones highly expressed ESC signature derived genes and the p53 Mut dependent genes in MSC TL sub-clones are enriched for chromatin transcriptional activation marks in ESCs. Supplementary Figure 6. The MSC-TLs ESC signature derived genes are associated with poor patient survival. Supplementary Figure 7. Six hotspot p53 mutations frequency in TCGA datasets. Supplementary Figure 8. ESC gene expression signature entailed in the MSC TLs is detected in human tumors harboring p53 missense mutations. Supplementary Table 1 List of QRT PCR primers. Supplementary Table 7 Description of TCGA samples.
Tables S3 & S4 from The Autotaxin—Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis
Authors: Magkrioti Christiana , Oikonomou Nikos , Kaffe Eleanna , Mouratis Marios-Angelos , Xylourgidis Nikos , Barbayianni Iliana , Megadoukas Petros , Harokopos Vaggelis , Valavanis Christos , Chun Jerold , Kosma Alexandra , Stathopoulos Georgios T. , Bouros Evangelos , Bouros Demosthenes , Syrigos Konstantinos , Aidinis Vassilis
Published: April 2023

Deregulated genes (S3) and pathways (S4) upon the stochastic deletion of Enpp2 in pulmonary cells
Table S1 from The Autotaxin—Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis
Authors: Magkrioti Christiana , Oikonomou Nikos , Kaffe Eleanna , Mouratis Marios-Angelos , Xylourgidis Nikos , Barbayianni Iliana , Megadoukas Petros , Harokopos Vaggelis , Valavanis Christos , Chun Jerold , Kosma Alexandra , Stathopoulos Georgios T. , Bouros Evangelos , Bouros Demosthenes , Syrigos Konstantinos , Aidinis Vassilis
Published: April 2023

Expression profiling of the ATX/LPA axis in meta-analyzed, publicly available microarray datasets of human lung cancer
Figure S4 from The Autotaxin—Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis
Authors: Magkrioti Christiana , Oikonomou Nikos , Kaffe Eleanna , Mouratis Marios-Angelos , Xylourgidis Nikos , Barbayianni Iliana , Megadoukas Petros , Harokopos Vaggelis , Valavanis Christos , Chun Jerold , Kosma Alexandra , Stathopoulos Georgios T. , Bouros Evangelos , Bouros Demosthenes , Syrigos Konstantinos , Aidinis Vassilis
Published: April 2023

Decreased Enpp2 and Plpp1,3 mRNA expression in animal models of lung cancer
Figure S1 from The Autotaxin—Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis
Authors: Magkrioti Christiana , Oikonomou Nikos , Kaffe Eleanna , Mouratis Marios-Angelos , Xylourgidis Nikos , Barbayianni Iliana , Megadoukas Petros , Harokopos Vaggelis , Valavanis Christos , Chun Jerold , Kosma Alexandra , Stathopoulos Georgios T. , Bouros Evangelos , Bouros Demosthenes , Syrigos Konstantinos , Aidinis Vassilis
Published: April 2023

ENPP2 is genetically altered in 8% of NSCLC patients, co-amplified with MYC and other 8q24genes
Supplementary Figure S3A-D from Preclinical Evaluation of the Hsp70 Peptide Tracer TPP-PEG24-DFO[89Zr] for Tumor-Specific PET/CT Imaging
Authors: Stangl Stefan , Tei Lorenzo , De Rose Francesco , Reder Sybille , Martinelli Jonathan , Sievert Wolfgang , Shevtsov Maxim , Öllinger Rupert , Rad Roland , Schwaiger Markus , D'Alessandria Calogero , Multhoff Gabriele
Published: April 2023

Radio-TLC Analysis and stability testing of TPP-PEG24-DFO[89Zr] and cmHsp70.1-DFO[89]
Supplementary Figures S1-S7 from LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody–Drug Conjugates
Authors: Purcell James W. , Tanlimco Sonia G. , Hickson Jonathan , Fox Melvin , Sho Mien , Durkin Lisa , Uziel Tamar , Powers Rick , Foster Kelly , McGonigal Thomas , Kumar Subashri , Samayoa Josue , Zhang Dong , Palma Joann P. , Mishra Sasmita , Hollenbaugh Diane , Gish Kurt , Morgan-Lappe Susan E. , Hsi Eric D. , Chao Debra T.
Published: April 2023

Figures S1-S7 show LRRC15 RNA and protein expression in cancer, and demonstrate the anti-tumor efficacy of the LRRC15-targeted ADC ABBV-085 in vitro and in vivo as a monotherapy and in combination with standard-of-care therapies.
Table S1 and S2 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
Authors: Hiller Björn , Hoppe Anja , Haase Christa , Hiller Christina , Schubert Nadja , Müller Werner , Reijns Martin A.M. , Jackson Andrew P. , Kunkel Thomas A. , Wenzel Jörg , Behrendt Rayk , Roers Axel
Published: April 2023

This file contains transcripts induced by type I interferon (S1) or regulated by p53 in response to DNA damage (S2).
Supplementary Information from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
Authors: Hiller Björn , Hoppe Anja , Haase Christa , Hiller Christina , Schubert Nadja , Müller Werner , Reijns Martin A.M. , Jackson Andrew P. , Kunkel Thomas A. , Wenzel Jörg , Behrendt Rayk , Roers Axel
Published: April 2023

Histopathological characterization of mutant skin
Figure S4 from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
Authors: Hiller Björn , Hoppe Anja , Haase Christa , Hiller Christina , Schubert Nadja , Müller Werner , Reijns Martin A.M. , Jackson Andrew P. , Kunkel Thomas A. , Wenzel Jörg , Behrendt Rayk , Roers Axel
Published: April 2023

Influence of p53-deficiency on phenotype of Rnaseh2EKO mice.
Table S8 from A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk
Authors: Lu Yingchang , Beeghly-Fadiel Alicia , Wu Lang , Guo Xingyi , Li Bingshan , Schildkraut Joellen M. , Im Hae Kyung , Chen Yian A. , Permuth Jennifer B. , Reid Brett M. , Teer Jamie K. , Moysich Kirsten B. , Andrulis Irene L. , Anton-Culver Hoda , Arun Banu K. , Bandera Elisa V. , Barkardottir Rosa B. , Barnes Daniel R. , Benitez Javier , Bjorge Line , Brenton James , Butzow Ralf , Caldes Trinidad , Caligo Maria A. , Campbell Ian , Chang-Claude Jenny , Claes Kathleen B.M. , Couch Fergus J. , Cramer Daniel W. , Daly Mary B. , deFazio Anna , Dennis Joe , Diez Orland , Domchek Susan M. , Dörk Thilo , Easton Douglas F. , Eccles Diana M. , Fasching Peter A. , Fortner Renée T. , Fountzilas George , Friedman Eitan , Ganz Patricia A. , Garber Judy , Giles Graham G. , Godwin Andrew K. , Goldgar David E. , Goodman Marc T. , Greene Mark H. , Gronwald Jacek , Hamann Ute , Heitz Florian , Hildebrandt Michelle A.T. , Høgdall Claus K. , Hollestelle Antoinette , Hulick Peter J. , Huntsman David G. , Imyanitov Evgeny N. , Isaacs Claudine , Jakubowska Anna , James Paul , Karlan Beth Y. , Kelemen Linda E. , Kiemeney Lambertus A. , Kjaer Susanne K. , Kwong Ava , Le Nhu D. , Leslie Goska , Lesueur Fabienne , Levine Douglas A. , Mattiello Amalia , May Taymaa , McGuffog Lesley , McNeish Iain A. , Merritt Melissa A. , Modugno Francesmary , Montagna Marco , Neuhausen Susan L. , Nevanlinna Heli , Nielsen Finn C. , Nikitina-Zake Liene , Nussbaum Robert L. , Offit Kenneth , Olah Edith , Olopade Olufunmilayo I. , Olson Sara H. , Olsson Håkan , Osorio Ana , Park Sue K. , Parsons Michael T. , Peeters Petra H.M. , Pejovic Tanja , Peterlongo Paolo , Phelan Catherine M. , Pujana Miquel Angel , Ramus Susan J. , Rennert Gad , Risch Harvey , Rodriguez Gustavo C. , Rodríguez-Antona Cristina , Romieu Isabelle , Rookus Matti A. , Rossing Mary Anne , Rzepecka Iwona K. , Sandler Dale P. , Schmutzler Rita K. , Setiawan Veronica W. , Sharma Priyanka , Sieh Weiva , Simard Jacques , Singer Christian F. , Song Honglin , Southey Melissa C. , Spurdle Amanda B. , Sutphen Rebecca , Swerdlow Anthony J. , Teixeira Manuel R. , Teo Soo H. , Thomassen Mads , Tischkowitz Marc , Toland Amanda E. , Trichopoulou Antonia , Tung Nadine , Tworoger Shelley S. , van Rensburg Elizabeth J. , Vanderstichele Adriaan , Vega Ana , Edwards Digna Velez , Webb Penelope M. , Weitzel Jeffrey N. , Wentzensen Nicolas , White Emily , Wolk Alicja , Wu Anna H. , Yannoukakos Drakoulis , Zorn Kristin K. , Gayther Simon A. , Antoniou Antonis C. , Berchuck Andrew , Goode Ellen L. , Chenevix-Trench Georgia , Sellers Thomas A. , Pharoah Paul D.P. , Zheng Wei , Long Jirong
Published: April 2023

Association results between minor alleles of 467 variants incorportated in cross tissue gene expression prediction model for the gene of CRHR1.
Figure S6 from Glycoprotein nmb Is Exposed on the Surface of Dormant Breast Cancer Cells and Induces Stem Cell–like Properties
Authors: Chen Chen , Okita Yukari , Watanabe Yukihide , Abe Fumie , Fikry Muhammad Ali , Ichikawa Yumu , Suzuki Hiroyuki , Shibuya Akira , Kato Mitsuyasu
Published: April 2023

Expression levels of tyrosine kinase receptors in breast cancer cells cultured in 2D or 3D culture conditions.
Supplementary movie2 from Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor
Authors: Matsunaga Naoya , Ogino Takashi , Hara Yukinori , Tanaka Takahiro , Koyanagi Satoru , Ohdo Shigehiro
Published: April 2023

The bioluminescence of cultured Aldh3a1::Luc- expressing 4T1 cells was recorded using a real-time monitoring system. The ALDH-positive populations of Aldh3a1::Luc-expressing 4T1 cells were cultured on VECELL 3D inserts and these VECELL 3D inserts were co-cultured into 35 mm culture dish which were seeding the cells treated with 0 nM dexamethasone.
Figure S3 from Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer
Authors: Srinivasan Supriya , Totiger Tulasigeri , Shi Chanjuan , Castellanos Jason , Lamichhane Purushottam , Dosch Austin R. , Messaggio Fanuel , Kashikar Nilesh , Honnenahally Kumaraswamy , Ban Yuguang , Merchant Nipun B. , VanSaun Michael , Nagathihalli Nagaraj S.
Published: April 2023

Figure S3 shows CREB inhibition using 666-15 drug in PDAC cells and qPCR data
Table S3 from Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer
Authors: Xiao Lanbo , Tien Jean C. , Vo Josh , Tan Mengyao , Parolia Abhijit , Zhang Yajia , Wang Lisha , Qiao Yuanyuan , Shukla Sudhanshu , Wang Xiaoju , Zheng Heng , Su Fengyun , Jing Xiaojun , Luo Esther , Delekta Andrew , Juckette Kristin M. , Xu Alice , Cao Xuhong , Alva Ajjai S. , Kim Youngsoo , MacLeod A. Robert , Chinnaiyan Arul M.
Published: April 2023

Supplementary Table 3 Primer and sgRNA sequences used in the study.
Table S1 from IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer
Authors: Wu Te-Chia , Xu Kangling , Martinek Jan , Young Robyn R. , Banchereau Romain , George Joshy , Turner Jacob , Kim Kyung In , Zurawski Sandra , Wang Xuan , Blankenship Derek , Brookes Hannah M. , Marches Florentina , Obermoser Gerlinde , Lavecchio Elizabeth , Levin Maren K. , Bae Sookyoung , Chung Cheng-Han , Smith Jennifer L. , Cepika Alma-Martina , Oxley Kyp L. , Snipes George J. , Banchereau Jacques , Pascual Virginia , O'Shaughnessy Joyce , Palucka A. Karolina
Published: April 2023

Cytokines screening from breast tumor tissue
Figure S1 to S7 from MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells
Authors: Bayley Rachel , Blakemore Daniel , Cancian Laila , Dumon Stephanie , Volpe Giacomo , Ward Carl , Almaghrabi Ruba , Gujar Jidnyasa , Reeve Natasha , Raghavan Manoj , Higgs Martin R. , Stewart Grant S. , Petermann Eva , García Paloma
Published: April 2023

Seven supplementary figures. Figure S1. Proliferation capacity of expanded CD34+ cells purified from MDS patient PBMC samples.Figure S2. Absolute numbers of bone marrow stem cell subpopulations in wild type and Mybl2 deficient animals.Figure S3. Recruitment of 53BP1 after irradiation in Mybl2 deficient HSC. Figure S4. Cell cycle status of bone marrow stem cell subpopulations in wild type and Mybl2 deficient animals. Figure S5. Proliferation and apoptosis of bone marrow stem cell subpopulations in wild type and Mybl2 deficient animals post-irradiation. Figure S6. Effect of ATM inhibition on 53BP1 foci and colony formation in wild type and MYBL2 deficient HSC. Figure S7. The G2M checkpoint in response to irradiation is ATM-dependent in MYBL2 deficient HSC.
Supplementary Figures from HER2 Amplification in Tumors Activates PI3K/Akt Signaling Independent of HER3
Authors: Ruiz-Saenz Ana , Dreyer Courtney , Campbell Marcia R. , Steri Veronica , Gulizia Nate , Moasser Mark M.
Published: April 2023

Figure S1 - A) HCC1569-HER3WT and HCC1569-HER3KO immunoblots, soft agar assays, and FISH assays. Figure S2 - Phospho-RTK array legend and darker exposures Figure S3 - H&E and Ki67 stains of HCC1569KO tumors Figure S4 - Confirmation of human specificity of anti-vimentin Ab Figure S5 - Lack of expression of HER family members in NR6 cells Figure S6 - p85 isoform expression in cell lines and Ras knockdowns in HCC1569 cells Figure S7 - Prolonged HER3 knockdown in HCC1569 cells Figure S8 - expression of HER2 YF mutants
Supplementary Table S5 from Sex Differences in Cancer Driver Genes and Biomarkers
Authors: Li Constance H. , Haider Syed , Shiah Yu-Jia , Thai Kevin , Boutros Paul C.
Published: April 2023

Summary of all sex-bias analysis of copy number aberrations and point mutations
Supplementary Data from Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy
Authors: Lee Hee-Sheung , Carmena Mar , Liskovykh Mikhail , Peat Emma , Kim Jung-Hyun , Oshimura Mitsuo , Masumoto Hiroshi , Teulade-Fichou Marie-Paule , Pommier Yves , Earnshaw William C. , Larionov Vladimir , Kouprina Natalay
Published: April 2023

14 Supplementary Figures and 2 Supplementary Tables
Supplementary Table S1 from p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4
Authors: Kajiwara Chihiro , Fumoto Katsumi , Kimura Hirokazu , Nojima Satoshi , Asano Keita , Odagiri Kazuki , Yamasaki Makoto , Hikita Hayato , Takehara Tetsuo , Doki Yuichiro , Morii Eiichi , Kikuchi Akira
Published: April 2023

Antibodies, shRNA, siRNA used in this study.
Supplementary Figure S5 from Proteolytic Release of the p75NTR Intracellular Domain by ADAM10 Promotes Metastasis and Resistance to Anoikis
Authors: Bao Xin , Shi Jianbo , Xie Furong , Liu Zengying , Yu Jingshuang , Chen Wantao , Zhang Zhiyuan , Xu Qin
Published: April 2023

FAK signaling has little effect on NF-κB activation as well as anoikis, and neither ADAM10 nor p75NTR ICD affects EGFR signaling.
Supplementary Figure S2 from Proteolytic Release of the p75NTR Intracellular Domain by ADAM10 Promotes Metastasis and Resistance to Anoikis
Authors: Bao Xin , Shi Jianbo , Xie Furong , Liu Zengying , Yu Jingshuang , Chen Wantao , Zhang Zhiyuan , Xu Qin
Published: April 2023

ADAM17 has little effect on p75NTR shedding and p75NTR ICD promotes anchorage-independent growth.
Supplemental Figure S5 from Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1
Authors: Werfel Thomas A. , Elion David L. , Rahman Bushra , Hicks Donna J. , Sanchez Violeta , Gonzales-Ericsson Paula I. , Nixon Mellissa J. , James Jamaal L. , Balko Justin M. , Scherle Peggy A. , Koblish Holly K. , Cook Rebecca S.
Published: April 2023

Supplemental Figure S5. Decreased tumor cellularity of tumors treated with the combination of lapatinib + BMS-777607 + epacadostat. Low power images of H&E-stained sections of tumors collected at treatment day 7. Arrows point to tumor cells, which stain darker purple, and which are evident as solid sheets in vehicle-treated samples, but only as pockets in the samples treated with lapatinib + BMS-777607 + Epacadostat. Asterisks represent areas of acellular debris.
Supplemental Figure S4 from Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1
Authors: Werfel Thomas A. , Elion David L. , Rahman Bushra , Hicks Donna J. , Sanchez Violeta , Gonzales-Ericsson Paula I. , Nixon Mellissa J. , James Jamaal L. , Balko Justin M. , Scherle Peggy A. , Koblish Holly K. , Cook Rebecca S.
Published: April 2023

Supplemental Figure S4. THP-1 cells differentiated with M-CSF were assessed for their ability to polarize to an M1 phenotype in response to LPS treatment. Cells were treated for 24 hrs. with LPS (700ng/mL). Activation was analyzed via flow cytometry comparing CD86 expression on LPS treated cells to untreated cells and quantified. Differentiated THP-1 cells were treated with either BMS777607 (final concentration of 1uM) or DMSO (1:1000) for 2hrs. then co-cultured with BT474 cells [treated with either DMSO (1:1000) or Lapatinib (1uM) for 2hrs.] for a total of 4 hours, before being collected for RNA isolation and qPCR. TUNEL analysis of tumors harvested from MMTV-Neu tumor-bearing mice at treatment day 2 and treatment day 7. Representative images are shown.
Table S3 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer
Authors: Seo Jae Ho , Chae Young Chan , Kossenkov Andrew V. , Lee Yu Geon , Tang Hsin-Yao , Agarwal Ekta , Gabrilovich Dmitry I. , Languino Lucia R. , Speicher David W. , Shastrula Prashanth K. , Storaci Alessandra Maria , Ferrero Stefano , Gaudioso Gabriella , Caroli Manuela , Tosi Davide , Giroda Massimo , Vaira Valentina , Rebecca Vito W. , Herlyn Meenhard , Xiao Min , Fingerman Dylan , Martorella Alessandra , Skordalakes Emmanuel , Altieri Dario C.
Published: April 2023

Clinico-pathological characteristics of non-small cell lung cancer (NSCLC) patient series used in this study (n=72)
Supplementary Figure S1 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer
Authors: Seo Jae Ho , Chae Young Chan , Kossenkov Andrew V. , Lee Yu Geon , Tang Hsin-Yao , Agarwal Ekta , Gabrilovich Dmitry I. , Languino Lucia R. , Speicher David W. , Shastrula Prashanth K. , Storaci Alessandra Maria , Ferrero Stefano , Gaudioso Gabriella , Caroli Manuela , Tosi Davide , Giroda Massimo , Vaira Valentina , Rebecca Vito W. , Herlyn Meenhard , Xiao Min , Fingerman Dylan , Martorella Alessandra , Skordalakes Emmanuel , Altieri Dario C.
Published: April 2023

MFF expression in cancer
Figure S4 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer
Authors: Seo Jae Ho , Chae Young Chan , Kossenkov Andrew V. , Lee Yu Geon , Tang Hsin-Yao , Agarwal Ekta , Gabrilovich Dmitry I. , Languino Lucia R. , Speicher David W. , Shastrula Prashanth K. , Storaci Alessandra Maria , Ferrero Stefano , Gaudioso Gabriella , Caroli Manuela , Tosi Davide , Giroda Massimo , Vaira Valentina , Rebecca Vito W. , Herlyn Meenhard , Xiao Min , Fingerman Dylan , Martorella Alessandra , Skordalakes Emmanuel , Altieri Dario C.
Published: April 2023

Requirements of MFF regulation of tumor cell death
Table S2 from Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy
Authors: Liu Changlong , Banister Carolyn E. , Buckhaults Phillip J.
Published: April 2023

Table S2. TP53 knockout hESCs resistant drugs
Supplementary Data from Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability
Authors: Zhang Jian , Li Ying-Qin , Guo Rui , Wang Ya-Qin , Zhang Pan-Pan , Tang Xin-Ran , Wen Xin , Hong Xiao-Hong , Lei Yuan , He Qing-Mei , Yang Xiao-Jing , Sun Ying , Ma Jun , Liu Na
Published: April 2023

Supplementary Figures S1-S8: -Figure S1. The SHISA3 promoter is hypermethylated in NPC. Figure S2. The SHISA3 promoter is hypermethylated in NPC cell lines. Figure S3. SHISA3 is hypermethylated in 18 primary solid tumors. Figure S4. Correlations between SHISA3 promoter methylation and mRNA expression in primary solid tumors. Figure S5. SHISA3 has little effect on NPC cell proliferation in vitro. Figure S6. SHISA3 stabilizes SGSM1 by impeding TRIM21-mediated deubiquitination. Figure S7. The effects of SHISA3 overexpression on nasopharyngeal carcinoma aggressiveness in vivo. Figure S8. SHISA3 has little effect on the canonical Wnt signaling pathway.
Supplementary Methods from Vitamin D–VDR Signaling Inhibits Wnt/β-Catenin–Mediated Melanoma Progression and Promotes Antitumor Immunity
Authors: Muralidhar Sathya , Filia Anastasia , Nsengimana Jérémie , Poźniak Joanna , O'Shea Sally J. , Diaz Joey M. , Harland Mark , Randerson-Moor Juliette A. , Reichrath Jörg , Laye Jonathan P. , van der Weyden Louise , Adams David J. , Bishop D.T. , Newton-Bishop Julia
Published: April 2023

Supplementary methods
Figure S7 from The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right
Authors: Park Derek S. , Robertson-Tessi Mark , Luddy Kimberly A. , Maini Philip K. , Bonsall Michael B. , Gatenby Robert A. , Anderson Alexander R.A.
Published: April 2023

Expanded model parameter analysis for effector cell death rates. Higher death rates lead to Goldilocks Window reduction and worse treatment outcomes.
Figure S6 from The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right
Authors: Park Derek S. , Robertson-Tessi Mark , Luddy Kimberly A. , Maini Philip K. , Bonsall Michael B. , Gatenby Robert A. , Anderson Alexander R.A.
Published: April 2023

Expanded model parameter analysis for memory cell growth rates. Greater memory cell expansion leads to a larger Goldilocks treatment window and a greater possible reduction in tumor sizes.
Supplementary Figure 2 from Vitamin D–VDR Signaling Inhibits Wnt/β-Catenin–Mediated Melanoma Progression and Promotes Antitumor Immunity
Authors: Muralidhar Sathya , Filia Anastasia , Nsengimana Jérémie , Poźniak Joanna , O'Shea Sally J. , Diaz Joey M. , Harland Mark , Randerson-Moor Juliette A. , Reichrath Jörg , Laye Jonathan P. , van der Weyden Louise , Adams David J. , Bishop D.T. , Newton-Bishop Julia
Published: April 2023

Comparison of VDR expression between primary melanomas of responders and non-responders to immunotherapy
Figure S4 from The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right
Authors: Park Derek S. , Robertson-Tessi Mark , Luddy Kimberly A. , Maini Philip K. , Bonsall Michael B. , Gatenby Robert A. , Anderson Alexander R.A.
Published: April 2023

Expanded model parameter analysis for memory cell expansion rate, gamma. Faster memory cell expansion leads to a larger Goldilocks Window and better possible outcomes.
Supplementary Tables S1-S8 from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease
Authors: Travnickova Jana , Wojciechowska Sonia , Khamseh Ava , Gautier Philippe , Brown Daniel V. , Lefevre Thomas , Brombin Alessandro , Ewing Ailith , Capper Amy , Spitzer Michaela , Dilshat Ramile , Semple Colin A. , Mathers Marie E. , Lister James A. , Steingrimsson Eiríkur , Voet Thierry , Ponting Chris P. , Patton E. Elizabeth
Published: April 2023

Supplementary file comprising Supplementary Tables S1-S8. Table S1: list of antibodies used in this study; Table S2: gene set from literature used for pathway analysis; Table S3: list of significantly enriched pathways from GSEA analysis between primary tumour and regression site (low cell number RNA-seq); Table S4: qPCR primers used in this study; Tables S5: list of shared upregulated pathways in superficial melanoma and low MITF patients; Table S6: list of shared upregulated pathways in nodular melanoma and high MITF patients; Table S7: list of pathways upregulated in paired comparison of zebrafish melanoma models; Table S8: list of upregulated pathways from pairwise comparison between individual clusters in single cell RNA-seq analysis.
Figure S7-S10 from Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma
Authors: Jung Jinkyu , Zhang Ying , Celiku Orieta , Zhang Wei , Song Hua , Williams Brian J. , Giles Amber J. , Rich Jeremy N. , Abounader Roger , Gilbert Mark R. , Park Deric M.
Published: April 2023

NIX is functional for responding oxidative stress signal.
Figure S6 from Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma
Authors: Jung Jinkyu , Zhang Ying , Celiku Orieta , Zhang Wei , Song Hua , Williams Brian J. , Giles Amber J. , Rich Jeremy N. , Abounader Roger , Gilbert Mark R. , Park Deric M.
Published: April 2023

NIX expression is involved in HIF/AKT/mTOR pathway and cancer stemness.
Figure S4 from Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma
Authors: Jung Jinkyu , Zhang Ying , Celiku Orieta , Zhang Wei , Song Hua , Williams Brian J. , Giles Amber J. , Rich Jeremy N. , Abounader Roger , Gilbert Mark R. , Park Deric M.
Published: April 2023

The expression pattern of BNIP3 is differently regulated, compared to that of NIX.
Figure S11 from Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma
Authors: Jung Jinkyu , Zhang Ying , Celiku Orieta , Zhang Wei , Song Hua , Williams Brian J. , Giles Amber J. , Rich Jeremy N. , Abounader Roger , Gilbert Mark R. , Park Deric M.
Published: April 2023

Supplementary Figure related with Figure 7
Figure S7 from ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma
Authors: Sachdeva Rohit , Wu Megan , Smiljanic Sandra , Kaskun Oleksandra , Ghannad-Zadeh Kimia , Celebre Angela , Isaev Keren , Morrissy A. Sorana , Guan Jennifer , Tong Jiefei , Chan Jeffrey , Wilson Taylor M. , Al-Omaishi Sayf , Munoz David G. , Dirks Peter B. , Moran Michael F. , Taylor Michael D. , Reimand Jüri , Das Sunit
Published: April 2023

Measurement of ID1 half-life by cycloheximide chase assays. U251 cells were pretreated with or without TMZ for 3 days, followed by treatment with cycloheximide for the indicated times. The cell lysates were then analyzed by Western blots.
Figure S6 from ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma
Authors: Sachdeva Rohit , Wu Megan , Smiljanic Sandra , Kaskun Oleksandra , Ghannad-Zadeh Kimia , Celebre Angela , Isaev Keren , Morrissy A. Sorana , Guan Jennifer , Tong Jiefei , Chan Jeffrey , Wilson Taylor M. , Al-Omaishi Sayf , Munoz David G. , Dirks Peter B. , Moran Michael F. , Taylor Michael D. , Reimand Jüri , Das Sunit
Published: April 2023

(A) Flow chart of patient sample analysis (B) Representative images of IHC staining for ID1 expression in a TMA cohort. Images of weak and strong intensity staining for tumor tissues are shown. (C) Representative qPCR analysis of ID1 expresssion in U251 cells. Cells were treated with 100uM TMZ for indicated timepoints. *P>0.1
Figure S5 from ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma
Authors: Sachdeva Rohit , Wu Megan , Smiljanic Sandra , Kaskun Oleksandra , Ghannad-Zadeh Kimia , Celebre Angela , Isaev Keren , Morrissy A. Sorana , Guan Jennifer , Tong Jiefei , Chan Jeffrey , Wilson Taylor M. , Al-Omaishi Sayf , Munoz David G. , Dirks Peter B. , Moran Michael F. , Taylor Michael D. , Reimand Jüri , Das Sunit
Published: April 2023

(A) Spearman correlation of ID1 vs EGFR gene expression in all glioblastoma patients. (B) Spearman correlation of ID1 vs EGFR gene expression in the Classical subtype. (C) Spearman correlation of ID1 gene expression and EGFR_pY1173 RPPA in the Classical subtype. (D) Spearman correlation of ID1 gene expression and EGFR_pY1173 RPPA in all GBM patients with available RPPA data.
Figure S1 from ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma
Authors: Sachdeva Rohit , Wu Megan , Smiljanic Sandra , Kaskun Oleksandra , Ghannad-Zadeh Kimia , Celebre Angela , Isaev Keren , Morrissy A. Sorana , Guan Jennifer , Tong Jiefei , Chan Jeffrey , Wilson Taylor M. , Al-Omaishi Sayf , Munoz David G. , Dirks Peter B. , Moran Michael F. , Taylor Michael D. , Reimand Jüri , Das Sunit
Published: April 2023

(A) From left: Lane 1-5 U251 CTR. Lane -. Negative control. Lane +. Positive control. Lane D+. Diluted positive control. Lane 7-10 ID1-/-U251.1. Lane 11-14 ID1-/-U251.2. (B) PCR method.
Supplementary Table 1 from Follistatin-like Protein 1 Inhibits Lung Cancer Metastasis by Preventing Proteolytic Activation of Osteopontin
Authors: Chiou Jean , Chang Yu-Chan , Tsai Hsing-Fang , Lin Yuan-Feng , Huang Ming-Shyan , Yang Chih-Jen , Hsiao Michael
Published: April 2023

Additional background information of CL1-0 and CL1-5 cells
Supplementary Table S9 from Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3
Authors: Zheng Zi-Qi , Li Zhi-Xuan , Zhou Guan-Qun , Lin Li , Zhang Lu-Lu , Lv Jia-Wei , Huang Xiao-Dan , Liu Rui-Qi , Chen FoPing , He Xiao-Jun , Kou Jia , Zhang Jian , Wen Xin , Li Ying-Qin , Ma Jun , Liu Na , Sun Ying
Published: April 2023

Supplementary Table S9. The predicted miRNAs that bind with FAM225A according to DIANA Tools
Supplementary Figures S1-S11 from Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3
Authors: Zheng Zi-Qi , Li Zhi-Xuan , Zhou Guan-Qun , Lin Li , Zhang Lu-Lu , Lv Jia-Wei , Huang Xiao-Dan , Liu Rui-Qi , Chen FoPing , He Xiao-Jun , Kou Jia , Zhang Jian , Wen Xin , Li Ying-Qin , Ma Jun , Liu Na , Sun Ying
Published: April 2023

Supplementary Figure S1. FAM225A is overexpressed in NPC and other tumor types. Supplementary Figure S2. Silencing METTL3 resulted in the decreased m6A level of total RNA. Supplementary Figure S3. FAM225A promotes NPC cell proliferation, migration and invasion in vitro. Supplementary Figure S4. FISH assay showed that FAM225A was mainly located in cytoplasmic. Supplementary Figure S5. FAM225A acts as a ceRNA for miR-590-3p and miR-1275. Supplementary Figure S6. The expression of FAM225A is negatively correlated with miR-590-3p and miR-1275 expression. Supplementary Figure S7. Silencing of miR-590-3p and miR-1275 endows NP69 and N2Tert cells with carcinogenicity in vitro. Supplementary Figure S8. miR-590-3p/miR-1275 are responsible for FAM225A-mediated proliferation, migration and invasion. Supplementary Figure S9. Correlation between FAM225A and ITGB3 expression in 12 other cancer types from the TCGA database. Supplementary Figure S10. FAM225A promotes NPC cell metastasis in vivo. Supplementary Figure S11. ITGB3 is responsible for FAM225A-meidated tumorigenesis and metastasis in vivo.
Supplementary Data from Chemotherapy-Induced Distal Enhancers Drive Transcriptional Programs to Maintain the Chemoresistant State in Ovarian Cancer
Authors: Shang Stephen , Yang Jiekun , Jazaeri Amir A. , Duval Alexander James , Tufan Turan , Lopes Fischer Natasha , Benamar Mouadh , Guessous Fadila , Lee Inyoung , Campbell Robert M. , Ebert Philip J. , Abbas Tarek , Landen Charles N. , Difeo Analisa , Scacheri Peter C. , Adli Mazhar
Published: April 2023

Supplementary Figures S1-2,4, describe cell viability curves of tested cell lines. Figure S3 and S5 show bioinformatic data for resistance upregulated gene sets (S3) and cisplatin-taxane comparison analysis(S5). Figure S6 shows ECAR and OCR experiments. Figure S7 is a heatmap of combination indices of cisplatin with JQ1. Figure S8 shows apoptosis rates of cell lines. S9-12 describe cell viability dynamics of SOX9 KOs.
Supplementary Data from Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma
Authors: Yoda Hiroyuki , Inoue Takahiro , Shinozaki Yoshinao , Lin Jason , Watanabe Takayoshi , Koshikawa Nobuko , Takatori Atsushi , Nagase Hiroki
Published: April 2023

Supplementary Figure S1. MYCN-amplified neuroblastoma cell lines are addicted to MYCN. Supplementary Figure S2. Cytotoxic evaluation of PI polyamides targeting the MYCN gene. Supplementary Figure S3. Direct alkylation of the targeted DNA of MYCN gene. Supplementary Figure S4. MYCN-A3 and MYCN-A4 inhibit MYCN expression and cell proliferation in MYCN-amplified neuroblastoma cell lines. Supplementary Figure S5. Global impact of MYCN-A3 on gene expression in MYCN-amplified neuroblastoma cells is comparable to that of CRISPR/Cas9 targeting MYCN. Supplementary Figure S6. MYCN-A3 induces cell cycle arrest and the expression levels of p53 family genes in neuroblastoma cell lines. Supplementary Figure S7. MYCN-A3 suppresses tumor growth in human neuroblastoma xenograft mouse models. Supplementary Figure S8. Pharmacological effects of MYCN-A3 on human MYCN-amplified neuroblastoma xenograft models in vivo. Supplementary Figure S9. MYCN-A3 affects the MYCN gene loci and not non-targeted gene loci.
Figure S7 from Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival
Authors: Moore Paul C. , Qi Jenny Y. , Thamsen Maike , Ghosh Rajarshi , Peng Justin , Gliedt Micah J. , Meza-Acevedo Rosa , Warren Rachel E. , Hiniker Annie , Kim Grace E. , Maly Dustin J. , Backes Bradley J. , Papa Feroz R. , Oakes Scott A.
Published: April 2023

Effects of UPR blockade on C57BL/6 mice