bluuebunny/crossref_metadata_2025 huggingface dataset:
Natural Alternatives to Non-biodegradable Polymers in 3D Printing of
Pharmaceuticals
Authors: Somwanshi Ayush , Wadhwa Pankaj , Raza Amir , Hudda Sharwan , Magan Muskan , Khera Kanav
Published: October 2023

Background:

Due to potential toxicity, non-biodegradable polymers used in 3D (3-dimensional)
printing of drugs could be dangerous for patient safety and the environment.

Objective:

This review aims to investigate the toxicity of non-biodegradable polymers and investigate the use
of natural materials as an alternative in 3D printing medicines. The study evaluates the dangers connected to
3D printing.

Methods:

A review of the literature on various 3D printing processes, such as inkjet printing, fused filament
manufacturing, and extrusion-related 3DP systems, was done for this study. Also, the use of cellulose derivatives
and natural materials in 3D printing and their potential as active excipients was proposed.

Results:

The review identified potential toxicity risks linked to non-biodegradable polymers used in drug 3D
printing. As a potential fix for this issue, the use of natural materials with improved mechanical and thermal
properties was explored. The use of cellulose derivatives as an alternative to non-biodegradable polymers in
3D printing pharmaceuticals was also investigated in the study.

Conclusion:

This study emphasises the significance of evaluating the risks connected to drug 3D printing and
recommends using natural materials as an alternative to non-biodegradable polymers. More study is required
to create secure and reliable 3D printing processes for pharmaceuticals.
Research Progress on Immunomodulatory Effects of Poly (Lactic-co-
Glycolic Acid) Nanoparticles Loaded with Traditional Chinese Medicine
Monomers
Authors: Song Bocui , Chen Qian , Tong Chunyu , Li Yuqi , Li Shuang , Shen Xue , Niu Wenqi , Hao Meihan , Ma Yunfei , Wang Yanhong
Published: October 2023

Immunomodulatory mechanisms are indispensable and key factors in maintaining the balance
of the environment in humans. When the immune function of the immune system is impaired,
autoimmune diseases occur. Excessive body fatigue, natural aging of the human body, malnutrition,
genetic factors and other reasons cause low immune function, due to which the body is prone to being
infected by bacteria or cancer. Clinically, the existing therapeutic drugs still have problems such
as high toxicity, long treatment cycle, drug resistance and high price, so we still need to explore and
develop a high efficiency and low toxicity drug. Poly(lactic-co-glycolic acid) (PLGA) refers to a nontoxic
polymer compound that exhibits excellent biocompatibility. Traditional Chinese medicine
(TCM) monomers come from natural plants, and have the characteristics of high efficiency and low
toxicity. Applying PLGA to TCM monomers can make up for the defects of traditional dosage forms,
improve bioavailability, reduce the frequency and dosage of drug use, and reduce toxicity and side
effects, thus having the characteristics of sustained release and targeting. Accordingly, PLGA nanoparticles
loaded with TCM monomers have been the focus of development. The previous research on
drug loading advantages, preparation methods, and immune regulation of TCM PLGA nanoparticles
is summarized in the following sections.
Gamma Secretase as an Important Drug Target for Management of
Alzheimer’s Disease: A Comprehensive Review
Authors: Tadros Hakem Fady , Farid Fouad Youstina , Arafa Reem K.
Published: October 2023

Alzheimer’s disease (AD) is a neurological disease that affects the memory. AD has
been attributed to the aggregations of amyloid-β (Aβ) peptides which result in the formation of
plaques that block the neuron-transferring process done by the brain memory cells. These plaques
are formed upon cleavage of Amyloid Precursor Protein (APP) by Gamma-Secretase (GS). GS
protein has around 141 substrates, the important two are APP and Notch. Considering one of the
hot spots in AD research, we focused on GS and its relation to AD. Moreover, a lot of research
was done on beta-secretase and drugs were developed to target it however, few drugs are established
for GS. GS contains four subunits: Presenilin (PS), PEN-2, Nicastrin, and APH-1. The catalytic
subunit is PS, which contains the active site for substrate binding, as well as the allosteric
and docking sites. Both PEN-2 and APH-1 are regulators for the stability and activity of GS. Nicastrin,
helps the substrates bind to the PS. Additionally, the role of the immuno-protein named
“IFITM3” and how it affects the immune system and its relation to AD is presented. GS is one of
the most studied proteins with many developed candidates as inhibitors (GSI) and modulators (GSM).
Examples of GSI are Semagacestat and Avagacestat while GSM includes E2012; which inhibits
the cleavage activity of GS. In this report, each of the four subunits of GS is described in detail,
along with the interactions between GS and its inhibitors or modulators. In addition, the
FDA-approved drugs are enlisted.
Identification of Potential Lead Compounds against BCL-2 through
In-silico Screening of Phytochemicals of Nigella sativa and Cuscuta reflexa
for Oral Squamous Cell Carcinoma Management
Authors: Begum N. Fazulunisa , Ramani Pratibha , Doble Mukesh , Ramasubramanian Abilasha
Published: October 2023

Significance of the study:

In silico analysis is frequently used in physicochemical characterisation,
the discovery and improvement of novel compounds with affinity to a target, and the elucidation
of absorption, distribution, metabolism, excretion, and toxicity features.

Aim and Objective:

The aim of this study is to assess the efficacy of Nigella sativa and Cuscuta reflexa
in targeting Bcl2-antiapoptotic protein in Oral Squamous Cell Carcinoma through in silico analysis.

Materials and Methods:

The present study was designed to formulate a drug against Oral Squamous
cell carcinoma against the target protein Bcl-2. Protein Database (PDB) was used to select and analyse
the protein. Based on the literature search, the original molecules selected were thymoquinone,
tannin pyrogallol, Cuscutin, kaempferol, nigellicine and the ligand structures were obtained ZINC15
database. Target protein structure was recognised through Protein sequence from PB (Protein Data
Bank). Swiss ADME was used for assessing the properties of the molecules. Twenty new molecules
were identified from zinc pharmer and docking was done for all the 20 using Swiss dock. Binding
energy was assessed and compared with the original molecules.ZINC73690300 and ZINC73690304 had better binding energy than that of original molecules. Both molecules can be potential candidates for Bcl2 inhibition to prevent OSCC.

Results:

ZINC73690300 and ZINC73690304 had better binding energy than that of the original molecules.
Both molecules can be potential candidates for Bcl-2 inhibition to prevent OSCC.

Conclusion:

The present study evaluated the binding energy and bioavailability of the combined extract,
thus attempting to predict the target ligand binding between the compounds in OSCC before
attempting in vitro studies.-
A Comprehensive Review of Preclinical Models for Polycystic Ovary
Syndrome
Authors: Kumar G. Santhana , Garg Kritika , Soni Arun , Dalal Mittal
Published: October 2023

Background:

Polycystic ovary syndrome (PCOS) is a reproductive, metabolic, and endocrine
disorder with unclear aetiology. PCOS, the most common cause of female reproductive and
metabolic disorders, is known to affect more than one in ten women globally. PCOS and associated
clinical manifestations are probably underdiagnosed despite their high occurrence.

Objective:

Alternative animal models have been employed to investigate the causes of PCOS or
assess potential treatments. In light of this piece of information, it is challenging to create an animal
model that accurately captures all components of this condition; nonetheless, the resemblance of an
animal model's biology and/or biochemical characteristics to the phenotypes of PCOS in humans
may boost its applicability.

Result:

The key characteristics of these models are closer to human situations when compared to
women with PCOS, as shown by this comparison. The creation and testing of drugs for the treatment
of PCOS are necessary.

Conclusion::

The overview of PCOS, current preclinical models, and appropriate models chosen in
different studies to mimic various phenotypes in PCOS studies are all covered in this review paper.
Additionally, we have outlined the benefits and drawbacks of PCOS animal models.
Latent Mastocytosis Triggered by COVID-19 Vaccination: A Case Report
Authors: Calogiuri Gianfranco , Foti Caterina , Congedo Maurizio , Nettis Eustachio , Paladini Luigi , Greco Giuseppina , Pavone Vincenzo , Vacca Angelo
Published: October 2023

Background:

Hereby, we describe the first case of latent mastocytosis triggered by
mRNA-based vaccine to prevent COVID-19 infection.

Case Presentation:

In a 42-year-old Arabian man affected by slight, undiagnosed mastocytosis,
the second dose of the COVID-19 vaccine made more blatant his latent disease. The postvaccination
diagnostic iter is illustrated and the potential reasons causing the onset of the cutaneous
mastocytosis are discussed.

Conclusion:

Clinicians should keep a longer follow-up of their patients after the COVID-19
vaccination, not related to few hours, for the risk of immediate-type adverse events only.
Lipid-based Nanoparticles (LNP) Structures used for Drug Delivery and
Targeting: Clinical Trials and Patents
Authors: Amarachi Chime Salome , Attama Anthony A.
Published: October 2023

Lipid based nanoparticle (LNP) structures commonly used for drug delivery already in clinical
use are generally classified into three viz vesicular systems, emulsion based systems and lipid
nanoparticles. The details of the types, basic structural characteristics in drug delivery, clinical trials,
and patents have been discussed in this work. Moreover, despite the therapeutic efficacies of LNPs,
there are some toxicity challenges associated with their use. These toxicities may be cytotoxicity or
genotoxicity; to overcome some of these challenges, some measures could be taken during preformulation
stages in order to circumvent it. These measures have been extensively discussed in this work.
LNPs are used in the targeting of immune cells, which are direct participants in a variety of diseases,
hence, are attractive targets for therapy. Cell specific targeting of therapeutic agent(s) helps to concentrate
and localize the therapeutic effect and, hence, lowers the systemic side effects, while simultaneously
increasing the management outcome. Nanotechnology and particle engineering helps distinguish
each immune cell from the other to deliver therapeutic agents and ensure in vivo stability as well as
sustained drug release. Surface modification of LNP is an important characteristic utilized in targeting
therapeutic agents and allows the utilization of various specific properties expressed in each immune
cell. These targeting strategies have been explored in this work exhaustively, and some of the companies
and academic labs that develop LNP have been discussed. Also, new ways of developing novel
patentable LNP have been discussed.
Yoga and Meditation in the Treatment of Neurological and Psychiatric Disorders
Authors: Ghosh Dastidar Debabrata , Bhattacharjee Payel , Das Pratyush , Jana Bachaspati , Bhunia Anirban
Published: October 2023

Background::

According to the Global Burden of Disease (GBD) study, the global
health impact of neurological and psychiatric disorders has been underestimated for years. Neuropsychiatric
disorders are now recognised as significant threats to public health. In conjunction
with modern pharmaceutical interventions, the clinical application of yoga and meditation techniques
has been increasingly recognised for their efficacy in treating various mental health conditions.

Objective::

This article aimed to provide a comprehensive review summarizing the influence of
yoga and meditation on the human brain, specifically focusing on their clinical implementation
for neurological and psychiatric disorders.

Methods::

A systematic search was conducted across PubMed and Google Scholar databases utilizing
diverse combinations of keywords, including yoga, meditation, neurogenesis, neurological
disorder, mental health, mindfulness, thought process, neuroimaging, and brain, to identify pertinent
literature for this review.

Results::

Prevalent neurological and psychiatric ailments in our society encompass multiple sclerosis,
epilepsy, migraine, fibromyalgia, cerebrovascular disease, Alzheimer's disease, major depression,
anxiety disorder, and chronic stress. Scientifically corroborated by clinical studies, the
advantageous effects of yoga and spiritual practices on these disorders have been substantiated.
As our understanding of the complex psychology and functionalities of the human brain progresses,
it becomes apparent that yoga and meditation facilitate neurogenesis and restore chemical
equilibrium. Such practices aid in dispelling intrusive thoughts, negating negative emotions,
and ameliorating stress, thereby offering relief to patients and progressively diminishing their
reliance on conventional medication.

Conclusion::

The integration of yoga and spiritual practices as complementary and non-invasive
adjunctive therapies represents a promising approach to addressing the spectrum of neurological
disorders plaguing modern society.
Ganoderma lucidum, a Potential Revolutionary Macro Fungus in the Field of Medicine
Authors: Rani Isha , Gupta Mehak , Sharma Samarth , Kaur Dr. Gagandeep , Sharma Pankaj
Published: October 2023

Ganoderma lucidum is a traditional Asian medication used in China, Korea, and Japan.
It is a well-known medicinal fungus that is regarded as the elixir of life. Polysaccharides,
proteins, enzymes, sterols, fatty acids, vitamins, minerals, and peptides are some of the 400
physiologically active substances. Anti-inflammatory, anti-ulcer, anti-diabetic, antiandrogenic,
anti-aging, anti-fibrotic, antioxidant, hepatoprotective, sleep-promoting, anticarcinogenic, chemo
and radioprotective, immunomodulation, estrogenic, and antibacterial properties are just a few of
the numerous reported pharmacological effects. This review will help us to examine the role that
this macro fungus holds in various therapeutic applications and how it can be a significant influence
in the field of medicine.
Detección de Vapor de Etanol por modificación de la conductividad eléctrica del Dióxido de Estaño
Authors: Huamán Fernando , Reyes Luis , Estrada Walter , Gutarra Abel
Published: October 2023

Se han fabricado, por el método de sinterizado, recubrimientos de oxido de estaño para detección de vapor de etanol. 
Después de un tratamiento térmico adecuado, se obtuvieron partículas de un bajo nivel de coalescencia. La detección de vapor se basa en los cambios de resistencia superficial del recubrimiento debido a la presencia de etanol. Para explicar este comportamiento se utilizó un modelo teórico simplificado basado en la adsorción superficial de moléculas ionizadas. 
Nuestros datos experimentales se ajustan  muy bien dentro del rango de 10-130ug/ml. Para la concentración de vapor en aire encontramos el vapor experimental de m=0.63 en la ecuación de conductancia dada por G=G0 [v]m
Structural Equation Model for Social Support and Quality of Life Among Individuals With Mental Health Disorders During the COVID-19 Pandemic
Authors: Tran Bach Xuan , Dam Vu Anh Trong , Auquier Pascal , Boyer Laurent , Fond Guillaume , Nguyen Hung Manh , Nguyen Hung Tuan , Le Huong Thi , Tran Ha Nhi Thi , Vu Giang Thu , Nguyen Manh Duc , Nguyen Duong Anh Thi , Ly Bang Viet , Latkin Carl A , Zhang Melvyn WB , Ho Roger CM , Ho Cyrus SH
Published: October 2023

Background

In light of the COVID-19 pandemic, the distribution of social support for mental health problems has likely become unequal. Family- and community-based social support has been recognized as a promising approach for mental disorders; however, limited global frameworks have been applied to developing countries such as Vietnam.

Objective

The aim of this study was to evaluate the quality of life and social support among patients with mental health disorders in Vietnam and to investigate the factors associated with quality of life among these patients.

Methods

A cross-sectional study was conducted on 222 psychiatric patients in Hanoi from 2020 to 2022. A structured questionnaire was developed based on four standardized scales: Mental Well-Being-5 scale, Multidimensional Scale of Perceived Social Support, EuroQoL-visual analog scale (EQ-VAS), and EuroQoL-5 dimensions-5 levels (EQ-5D-5L) scale. Tobit regression was used to identify factors associated with the EQ-5D-5L and EQ-VAS scores. Structural equation modeling was applied to verify the relationship between quality of life and social support.

Results

The results showed that perceived support from family scored the highest compared to support from friends and significant others. Patients with depression reported the lowest quality of life and perceived social support. Structural equation modeling showed a root mean square error of approximation of 0.055 (90% CI 0.006-0.090), comparative fit index of 0.954, Tucker-Lewis index of 0.892, and standardized root mean squared error of 0.036 (P<.001). The hypothetical model indicated statistically significant correlations between EQ-VAS score and social support (P=.004), EQ-5D-5L and mental well-being (P<.001), and social support and mental well-being (P<.001). Critical deterioration of quality of life and inconsistency in social support for patients with mental illness were also recorded.

Conclusions

There is a need to enhance social support and service delivery in Vietnam, focusing on occupation and quality of life. The correlations between social support, quality of life, and mental health issues suggest the potential of a clinical-social integrated intervention model of care.
Investigating Topical Steroid Withdrawal Videos on TikTok: Cross-Sectional Analysis of the Top 100 Videos
Authors: Haddad Firas , Abou Shahla William , Saade Dana
Published: October 2023

Background

Social media platforms like TikTok are a very popular source of information, especially for skin diseases. Topical steroid withdrawal (TSW) is a condition that is yet to be fully defined and understood. This did not stop the hashtag #topicalsteroidwithdrawal from amassing more than 600 million views on TikTok. It is of utmost importance to assess the quality and content of TikTok videos on TSW to prevent the spread of misinformation.

Objective

This study aims to assess the quality and content of the top 100 videos dedicated to the topic of TSW on TikTok.

Methods

This observational study assesses the content and quality of the top 100 videos about TSW on TikTok. A total of 3 independent scoring systems: DISCERN, Journal of the American Medical Association, and Global Quality Scale were used to assess the video quality. The content of the videos was coded by 2 reviewers and analyzed for recurrent themes and topics.

Results

This study found that only 10.0% (n=10) of the videos clearly defined what TSW is. Videos were predominantly posted by White, middle-aged, and female creators. Neither cause nor mechanism of the disease were described in the videos. The symptoms suggested itching, peeling, and dryness which resembled the symptoms of atopic dermatitis. The videos fail to mention important information regarding the use of steroids such as the reason it was initially prescribed, the name of the drug, concentration, mechanism of usage, and method of discontinuation. Management techniques varied from hydration methods approved for treatment of atopic dermatitis to treatment options without scientific evidence. Overall, the videos had immense reach with over 200 million views, 45 million likes, 90,000 comments, and 100,000 shares. Video quality was poor with an average DISCERN score of 1.63 (SD 0.56)/5. Video length, total view count, and views/day were all associated with increased quality, indicating that patients were interacting more with higher quality videos. However, videos were created exclusively by personal accounts, highlighting the absence of dermatologists on the platform to discuss this topic.

Conclusions

The videos posted on TikTok are of low quality and lack pertinent information. The content is varied and not consistent. Health care professionals, including dermatologists and residents in the field, need to be more active on the topic, to spread proper information and prevent an increase in steroid phobia. Health care professionals are encouraged to ride the wave and produce high-quality videos discussing what is known about TSW to avoid the spread of misinformation.
Integrating BMC and SBSC Approaches for Tangkahan Ecotourism Management Strategies in Gunung Leuser National Park, North Sumatra, Indonesia
Authors: Khoirunnisa Intan , Yustiana Yooce , Prihadi Nandang
Published: October 2023

Indonesia as mega-biodiversity country and various unique local wisdom activities are main attractions that can be enjoyed by world tourists. Global tourism trends to go back to nature drive development of ecotourism. Tangkahan is ecotourism area that offers variety of tourist attractions. However, as time goes by, Tangkahan ecotourism also faced some challenges that effect efficiency and effectiveness of organization. Therefore, it is necessary to design ecotourism performance strategy, that can be used to integrate business model canvas (BMC) into sustainable balanced scorecard (SBSC). This study aims to describe performance of business model using BMC, analyze performance business model using SWOT, and design performance management strategy by integrating BMC into SBSC. Field data in the form of primary and secondary data. Data analysis used to describe business model is BSC and SWOT, and strategy design used SBSC and PLS-SEM. Results of this study have confirmed that Tangkahan Ecotourism can be described by BMC with value proposition, key resources, key activities, key partnerships, customer segment, channels, customer relationship, revenue streams and cost structures. Evaluation results, suggest new BMC description, that needs to enhance and increase existing aspects of elements BMC owned. There are 16 strategies obtained from SBSC management strategy design.
Power through Culture: The Gender Paradigm in China’s Soft Power Engagement in the Global South
Authors: Kelkar Govind , Agarwal Ritu
Published: October 2023

Despite the growing scholarly interest in China as a Global South power, two themes remain under investigated: One of the ways in which China has used soft power to project its comprehensive national capabilities and international power. Another theme that is overlooked by the existing China scholarship is the issue of gender. The so-called “miracle” of China’s recent rise as an economic powerhouse has also been a highly gendered process about which millions of women within China and outside the home raised concerns about the task of stronger political policies and actions that can institute gender equality and non-discrimination for women and girls. Soft power has played an important role in China’s international relations and the Party-State legitimacy among the people in China in terms of improving national pride and demonstrating that the world outside China admires the Chinese way of life—its social, economic institutions, cultural values, and the communist party of China’s (CPC) governance system. This study presents an analysis of the gender equality paradigm in China’s soft power engagement in the Global South. A history of the CPC shows a consistent policy concern for women’s empowerment and gender equality, generally represented in the concept “women hold up half the sky”, and therefore entitled to their right to resources and equal position in society. Since the 18th National Congress the CPC, President Xi Jinping and the Central Committee committed to adhering the basic national policy of gender equality “as a code of conduct and value standard” for the entire society (China Government Network 2021:3) and advocated for women’s equal rights through strategic measures like participation in economic construction in the family and society, including “equal sharing of housework” and family responsibility such as care work (Chinese Government Network, 2021:31). Have these policy concerns for women’s empowerment been part of China’s structural system of soft power or part of China’s negotiations with any country in Asia?
The New History of Urbanization Representation: Another Face of New Century Novels
Authors: Shen Ming , Jia Zhijie , Chen Xincun , Kou Zeyu
Published: October 2023

From de-urbanization to urbanization, China has created a new history, it has mainly undergone a gradual transition from integration to diversification. Based on the actual cities in China in the new century after reform and opening up, one period of time which born at the end of 1978, we tend to interrogate the urban novel for corresponding to rural novel, is a reflection on cultural integration and de-urbanization. From three aspects including the transcendence of modernity, the urban and rural spatial narrative of new century novels and the presentation of urban landscapes, considering the recursive reality from rural China to urban China, we attempt to explore how the novel text represents China's urbanization, dig out the manifestations of human’s survival in the process of urbanization in China in the new century after seeking roots in rural areas, thus mirroring the mixed urban habitats of multiple ethnic groups in Guangxi.
The crumbs of colonialism: the immigration process-from savages to civilized and shifting of submission from one sovereign to another
Authors: Ahtesham Fatima
Published: October 2023

The following article aims to explore the aftermath of colonialism in different shapes and forms. Moreover, the paper will also explain the ways racial and national identities are affected in the building of nationalism and its consequent effects during the process of acquiring the citizenship of another country (shifting our submission to another sovereign). I argue that colonialization was not only geographical but also racial and intellectual. The theories that evolved in the racialized colonial period such as social evolution theory are still seen in some of the workings of institutions (such as the Immigration Office). However, the application of social evolution theory is much more subtle now and essentially reflects the same colonial mindset. Hence, I will conclude that because of historical connectivity and neocolonialism immigration becomes a right. I will also deduce that the complex yet unnecessary immigration process renders the "submission to the sovereign" in limbo which disturbs the whole idea of nationalism
INTRAGROUP CONFLICT AND COHESION IN INTERACTIVE SPORTS TEAMS
Authors: Dobrijević Gordana , Alčaković Slavko
Published: October 2023

The aims of this study are to: (a) identify the most frequently used conflict management style; (b) determine the level of cohesion; and (c) examine the relationship between conflict and cohesion in interactive sports teams. The study was conducted on a sample of 205 professional sports players from interactive sports teams from Serbia (basketball, handball, water polo, volleyball, and football teams). The data was collected through the Rahim Organizational Conflict Inventory – II (ROCII – II) and the Group Environment Questionnaire (GEQ). In relation to all of the sports considered, the findings revealed high levels of all four dimensions of cohesion (Group Integration – Task, Group Integration – Social, Individual Attractions to the Group – Task, and Individual Attractions to the Group – Social). The study has shown a positive correlation between cohesion and the collaborative conflict management style, and a negative correlation between cohesion and the competing style. Cooperation proved to be the most frequently used conflict management style, and competing proved the least frequently used style in interactive sports teams.
СОЦИО-ДЕМОГРАФСКЕ ДЕТЕРМИНАНТЕ УЧЕНИЧКИХ ПРАВА И ОБАВЕЗА У ОСНОВНОЈ ШКОЛИ
Authors: Perućica Ranka , Živanović Sanja , Kalajdzic Olivera
Published: October 2023

Today, in modern society, great attention is paid to children’s or pupils’ rights, so the questions of whether one should go to extremes, and what occurs to pupils’ obligations and duties rightly arise. Therefore, the aim of this research is to examine the assessments of pupils and teachers on the representation of pupils’ rights and obligations in primary school. The study is based on non-experimental research, and the techniques of survey and scaling were used. The research sample consists of two parts. The first part consists of 700 pupils of the sixth, seventh, eighth and ninth grade of primary school, while the second part of the sample consists of 101 primary school course teachers. The obtained research findings show that there are differences in the assessments of pupils and teachers on the representation of pupils’ rights and obligations in primary school. Differences were registered in pupils’ assessments in relation to gender, level of achievement in school, age and educational level of fathers, while the difference did not prove significant in relation to the variable educational level of mothers. The registered differences in teachers’ assessments of pupils’ rights and obligations were shown with regard to the teacher’s work experience and the teaching area. The obtained data can be useful for the development of theoretical and conceptual settings in this area, and their practical implications, i.e. recommendations and guidelines for the actors of the educational institution in implementing pupils’ rights and obligations, are even more important.
CRIMINAL GROUPS – CRIMINOLOGY AND SECURITY PERSPECTIVES (CASE STUDY: BOSNIA AND HERZEGOVINA)
Authors: Šikman Mile , Lalić Velibor
Published: October 2023

This paper analyses court cases which qualified as organised crime in Bosnia and Herzegovina (B&H). The final judgments were analysed according to the following criteria: the number of defendants; the continuity of membership within the crime organisation; the existence of criminal structure; the existence of a developed plan of activities; the type and number of the offences committed; influence on public authorities, the judiciary, and citizens; and sentences imposed on the defendants. This paper seeks to identify the extent to which court judgments are based on these criteria. A secondary analysis of the data related to the organised crime cases heard in the Court of Bosnia and Herzegovina in the period between 2015 and 2018 was conducted. This analysis encompassed 21 organised crime cases in which 27 judgments were pronounced. In the observed period (2015-2018), we identified two organised criminal groups that meet the criteria analysed. The identified number of organised criminal groups is minimal in relation to the total number of organised crime cases processed. Our findings contradict the prevailing view in public discourse that organised crime is a widespread security threat in BiH. The findings of our research demonstrated the existence of legal gaps, reflected in the lack of clear criteria on the basis of which OCGs can be distinguish from other forms of criminal activity. Legal and institutional weaknesses create opportunities for OCGs to operate and create a sense of insecurity among citizens in the already complex security environment in B&H.
Gastón García Cantú y mi relación con él
Authors: Suárez-Iñiguez Enrique
Published: October 2023

En este ensayo el autor da una panorámica de quién fue Gastón García Cantú y de su relación con él
Derecho Agrario Volumen I
Authors: Duarte Calzadias Tayde
Published: October 2023

La guía consta de cuatro unidades divididas en dos tomos, que te introducirán al estudio del derecho agrario, con la conceptualización y definición de la materia, estudio y análisis del régimen jurídico de la propiedad contenida en el artículo 27 constitucional y sus efectos jurídicos con las reformas del 6 de enero de 1992, con la formación de órganos administrativos para la procuración e impartición de la justicia agraria y la garantía de seguridad jurídica en la tenencia de la tierra.
Bibliotecas de los congresos locales de México: explorando sus políticas de información
Authors: Vargas Huerta Arturo
Published: October 2023

El objetivo del trabajo es presentar las políticas de información bibliotecarias de los congresos locales de México. Debido a la poca bibliografía sobre estas unidades de información, un segundo objetivo se enfocó en identificar a su personal, colecciones, áreas y servicios. Se interrogó, por medio de encuestas en línea, a los responsables de las bibliotecas para saber si en cada una de las áreas, servicios, manejo de colecciones y selección del personal se cuenta con una política de información que indique cómo se llevan a cabo las actividades. El instrumento utilizado fue un cuestionario que se elaboró con base en las Directrices para bibliotecas parlamentarias creadas por la IFLA. Se designa como investigación cuantitativa y documental. La muestra que se estudió fue de 17 bibliotecas. Las políticas de información se presentan con base en las áreas y servicios que –de acuerdo con la IFLA– deben tener este tipo de bibliotecas. Los resultados obtenidos demostraron que cuentan con políticas de información explícitas en los niveles institucional y organizacional. Se concluyó que a nivel local también se contemplan políticas de información, pero el estudio no comprueba si son explícitas.
Planeación, Urbanismo, Medio Ambiente y Desarrollo Sustentable, la Tetrarquía Esencial del Progreso Social y Estatal
Authors: Flores Trejo Fernando Guadalupe
Published: October 2023

El Estado como persona jurídica, se justifica por alcanzar las finalidades sociales. Para ello, cuenta con una serie de instrumentos que le permiten cumplir con los requerimientos sociales. Sin duda, la planeación, el urbanismo, el medio ambiente y el desarrollo sustentable, constituyen cuatro herramientas fundamentales para lograr el progreso de la sociedad y del propio Estado. La planeación permite ordenar y priorizar las necesidades sociales, el urbanismo es la ciencia encargada de estudiar el ordenamiento de las ciudades en sus aspectos físico, ambiental, social y económico, el medio ambiente representa el hábitat que debemos preservar y el desarrollo sustentable implica la conservación del status ambiental, en beneficio actual y de las futuras generaciones. Los cuatro contextos anteriores, poseen un desenvolvimiento independiente, pero su conectividad conjunta, posibilta el desenvolvi- miento de la sociedad y del Estado, en beneficio colectivo.
Dignidad humana: ¿Se opone a los derechos de los animales?
Authors: Sánchez Cárdenas Diego
Published: October 2023

Dentro de la discusión bioética, la dignidad es un concepto fundamental que ha generado un sinfín de posturas y comentarios a favor y en contra; sin embargo, es importante definirla y seguir escribiendo y leyendo sobre él. En el campo de la Bioética resulta indispensable abordar su concepción, ya que poco a poco asume un rol clave y da sentido a otros principios, aunque su aparente vaguedad da lugar a su mal uso mediante significaciones diversas. La riqueza de la presente obra no sólo se limita al concepto sino a su relación con los animales.
Kualitas Donat Berbahan Campuran Tepung Biji Bunga Matahari
Authors: Suda I Made Hendry Dwi Wira , Widhyandanta I Gede Dirga Surya Arya
Published: October 2023

Tujuan dari penelitian ini adalah untuk mengetahui kualitas dari donat berbahan campuran tepung biji bunga matahari yang dinilai dari kualitas rasa, aroma, tekstur, dan tampilan sehingga masyarakat dapat memanfaatkan biji bunga matahari agar bisa dijadikan inovasi terbaru yang dinilai dari segi rasa, aroma, tekstur, tampilan, daya tahan, biaya produksi dan hasil minat konsumen pada donat berbahan campuran tepung biji bunga matahari. Penelitian ini menggunakan teknik analisis data deskriptif berbasis organoleptic dimana melakukan proses percobaan atau trial terlebih dahulu agar menghasilkan sebuah produk yang layak dikonsumsi masyarakat, lalu membagikan kuisioner yang dibagikan kepada 15 orang panelis yang terdiri dari staff kitchen Amnaya Resort Kuta, mahasiswa/I IPB Internasional dan masyarakat sekitar. Hasil penelitian ini menunjukan bahwa donat berbahan campuran tepung biji bunga matahari memiliki rasa yang enak, aroma cukup sedap, tekstur yang lembut dan memiliki tampilan warna yang menarik. Lalu uji daya tahan dapat disimpulkan bahwa donat berbahan campuran tepung biji bunga matahari dapat bertahan selama 2 hari di suhu ruangan. Biaya produksi dalam pembuatan donat berbahan campuran tepung biji bunga matahari ini menghabiskan biaya sebesar Rp. 79.328,- dan dari hasil kuisioner minat konsumen menunjukan bahwa 13 dari 15 partisipan berminat untuk membeli donat berbahan campuran tepung biji bunga matahari ini jika dijual di pasaran.
 
The purpose of this study was to determine the quality of donuts made from a mixture of sun flower seed flour assessed from the quality of taste, aroma, texture, and appearance so that people can use sunflower seeds so that they can be used as the latest innovations judged in terms of taste, aroma, texture, appearance, durability, production cost and results of consumer interest in donuts made form a mixture of sunflower seed flour. This study uses an organoleptic based descriptive data analysis technique which conducts a trial process first in order to produce a product that is suitable for public consumption, then distributes questionnaires which are distributed to 15 panelists consisting of Amnaya Resort Kuta Kitchen staff, students/I IPB International and local communities. The results of this study indicate that donuts made from a mixture of sunflower seed flour have a good taste, quite delicious aroma, soft texture and have an attractive color appearance. Then the durability test can be conclude that donuts made from mixed sunflower seed flour can last for 2 days at room temperature. The production cost in making donuts made from a mixture of sunflower seed flour cost Rp.79.328,- and the results of the consumer interest questionnaire showed that 13 out of 15 participants were interested in buying donuts made from a mixture of sunflower seed flour if they were sold in the market.
Pengembangan Nori Sebagai Bahan Akumulasi Kue Nastar
Authors: Kambey Yuriko Mathilda , Kuntariati Utik
Published: October 2023

Kurangnya variasi penggunaan nori dalam makanan saat ini menjadikan penggunaan nori hanya digunakan pada makanan tertentu saja contohnya pada sushi. Hal ini yang membat peneliti melakukan penelitian dengan menambahkan nori pada nastar agar mengetahui kualitas kue nastar dalam segi warna, rasa, aroma, tekstur dan bentuk dan bisa mengetahui biaya yang di keluarkan dalam pembuatan akumulasi nori dalam kue nastar. Jenis penelitian yang peneliti gunakan dalam melakukan penlitian ini adalah eksperimen dengan menggunakan metode kuantitatif. Data kuantitatif didaptkan dari hasil uji organoleptik menggunakan uji mann-whitney. Panelis dari penelitian ini terdiri dari 15 orang dari kalangan masyarakat dan 5 orang chef hotel Le Meridien Jimbaran. Berdasarkan uji Mann-Whitney didapatkan hasil bahwa dari segi rasa, aroma, warna terdapat perbedaan yang signifikan, sedangkan dari segi tekstur dan bentuk ditemukan tidak ada perubahan yang signifikan. Pengeluaran biaya yang di dapatkan dari pembuatan nastar nori adalah Rp.143.650 untuk 42pcs.
 
The lack of variety in the use of nori in today's food makes the use of nori only used in certain foods, for example in sushi. This is what makes the researchers cdonduct this research by adding nori to nastar cakes in order to determine the quality of nastar cakes in terms of color, taste, aroma, teture and shape and can find out the costs incurred in making the accumulation of nori in nastar cakes. The type from research used in this study is an experment using quantitative methods. Quantitative data were obtined from the results of organoleptic tests using the Mann-Whitney test. The panelists of this study consisted of 15 people from the community and 5 chefs at the Le Meridien Jimbaran hotel. Based on the Mann-Whitney test, it was fund that in tems of taste, aroma, color there were significant differences, while in terms of texture and shape there were no significant changes. The cost of making nastar nori is Rp. 143,650 for 42 pcs.
Pengaruh Insentif dan Lingkungan Kerja terhadap Kinerja Karyawan
Authors: Negara I Kadek Satria , Sulasmini Ni Made Ayu , Widhyandanta I Gede Dirga Surya Arya
Published: October 2023

Tujuan penelitian ini untuk mengetahui pengaruh variabel Insentif (X1) dan Lingkungan Kerja (X2) terhadap Kinerja Karyawan (Y). Penelitian ini dilakukan di Canggu Cafe, yaitu pada bulan Maret sampai dengan Juli 2021. Jenis data penelitian yang digunakan adalah kuantitatif. Metode analisis data yang digunakan dalam penelitian ini adalah regresi linear berganda yang digunakan untuk mengetahui pengaruh Insentif (X1) dan Lingkungan Kerja (X2) terhadap Kinerja Karyawan (X2) di Canggu Cafe, dengan penyebaran kuesioner kepada seluruh karyawan yaitu sebanyak 31 orang. Pengujian hipotesis penelitian menggunakan SPSS. Hasil penelitian ini menunjukan Insentif (X1) berpengaruh signifikan (p<0.05) secara parsial terhadap Kinerja (Y). Kemudian Lingkungan Kerja (X2) berpengaruh secara signifikan (p<0.05) secara parsial terhadap Kinerja (Y). Insentif (X1) dan Lingkungan Kerja (X2) berpengaruh signifikan (p<0.05) secara simultan terhadap Kinerja (Y) Karyawan, dengan persamaan regresi Y (Kinerja) = 7.551 + 0.267 X1 (Insentif) + 0.183 X2 (Lingkungan Kerja). Disarankan insentif dan lingkungan kerja diperhatikan oleh manajemen karena akan mempengaruhi kinerja karyawan di Canggu Cafe.
 
This research aims to find out the effect of variables (X1) Incentive and (X2) Working Environment on (Y) Working Performance. This research is conducted at Canggu Cafe from March to July 2021. The type of research data used was quantitative. The method of data analyses used multiple linear regression by distributing questionnaires to all 31 employees (respondents) and used saturation sampling technique and also processed by SPSS. The results of this research indicate that Incentive (X1) has significant (p<0.05) partially on Working Performance (Y). Then Working Environment (X2) has significant (p<0.05) partially on Working Performance (Y). Incentive (X1) and Working Environment (X2) has significant (p<0.05) simultaneously on Working Performance (Y) with the regression equation Y (Working Performance) = 7.551 + 0.267 X1 (Incentive) + 0.183 X2 (Working Environment). It is suggested that incentive and working environment need to be concerned by management due to influence working performance to the employees.
Analisis Selisih Beverage Cost di The Monkey Bar at Bella Kita
Authors: Saputra I Made Agus Dwika Yadnya Ambara , Wijaya Nyoman Surya , Widhyadanta I Gede Dirga Surya Arya
Published: October 2023

Tujuan penelitian ini adalah untuk mencari selisih antara standard dengan actual beverage cost dan penyebab terjadinya selisih beverage cost di The Monkey Bar At Bella Kita Klungkung. Metode yang digunakan adalah analisis Deskriptif Kuantitatif dengan teknik pengumpulan data observasi, studi dokumentasi, dan wawancara. Hasil penelitian memberikan indikasi bahwa: 1) selisih harga pokok minuman untuk actual beverage cost periode Januari sampai Desember 2019 terjadi melampaui standard beverage cost yang telah ditetapkan. 2) selisih net consumption antara harga standar dengan harga sesungguhnya disebabkan karena dalam pembelian bahan minuman pada bagian purchasing tidak menjelaskan kriteria atau spesifikasi bahan minuman yang di pesan pada supplier, sehingga menyebabkan pembelian melebihi standar yang telah ditetapkan. 3) selisih total harga standar dengan total harga sesungguhnya disebabkan oleh tidak sesuainya standard yield dan standard portion size yang telah ditetapkan. 4) kenaikan persentase beverage cost reconciliation disebabkan oleh peningkatan yang terjadi pada total purchase, gross consumption dan net consumption.
 
The purpose of this study was to find the difference between standard and actual beverage cost and the causes of the difference in beverage cost at The Monkey Bar At Bella Kita Klungkung. The method used is quantitative descriptive analysis with observation data collection techniques, documentation studies, and interviews. The results of the study indicate that: 1) the difference in the cost of drinks for the actual beverage cost for the period January to December 2019 occurs beyond the standard beverage cost that has been set. 2) the difference in net consumption between the standard price and the actual price is because the purchasing of beverage ingredients in the purchasing department does not explain the criteria or specifications for the beverage ingredients ordered to the supplier, thus causing the purchase to exceed the predetermined standard. 3) the difference between the total standard price and the actual total price is caused by the discrepancy between the standard yield and the predetermined standard portion size. 4) the increase in the percentage of beverage cost reconciliation was caused by an increase in total purchases, gross consumption and net consumption.
Kualitas Cookies Berbahan Campuran Tepung Labu Kuning
Authors: Shinta Syahrifah , Lestari Denok
Published: October 2023

Cookies adalah kue kering yang bertekstur renyah, berbentuk pipih dan biasanya berbentuk kecil. Pada umumnya cookies berbahan tepung terigu. Namun kalori yang terkandung dalam tepung terigu sangatlah tinggi. Dalam hal ini peneliti ingin mengurangi ketergantungan penggunaan tepung terigu dengan salah satu jenis buah yang dimana masyarakat masih awam dalam pengolahannya, yaitu buah labu kuning, yang dapat ditemukan dengan sangat mudah dipasaran. Peneliti ingin membuat inovasi baru yaitu produk cookies berbahan campuran tepung labu kuning. Tujuan penelitian ini untuk mengetahui bagaimana kualitas, daya tahan produk, serta biaya pembuatan produk. Eksperimen ini dilakukan dengan metode penelitian dan pengumpulan data. Percobaan ini menggunakan tiga formulasi dengan rasio: P1 = 25% tepung labu kuning dan 75% tepung terigu, P2 = 50% tepung labu kuning dan 50% tepung terigu, P3 = 75% tepung labu kuning dan 25% tepung terigu. Berdasarkan hasil uji organoleptik yang diujikan kepada 20 panelis ahli, cookies (P2) mendapatkan nilai terbaik dengan skor 316. Dalam kurun waktu 7 hari, produk cookies tidak mengalami penurunan kualitas. Total biaya yang diperlukan adalah Rp. 42.650,- sedangkan dengan per satu piece cookies dengan berat 25 gram sebesar Rp. 2000.-
 
Cookies are pastries that are crunchy in texture, flat in shape and usually small in shape. In general, cookies are made from wheat flour. However, the calories contained in wheat flour are very high. In this case the researcher wants to reduce the dependence on the use of wheat flour with one type of fruit that is still foreign in its processing, namely pumpkin which is very easy to find in the market. Researchers want to make a new innovation, namely a pastry product made from a mixture of pumpkin flour. The purpose of this research is to find out how the quality, durability of the product, and the cost of making the product are. This experiment was conducted using research methods and data collection. This experiment used three formulations with ratios: P1 = 25% pumpkin flour and 75% wheat flour, P2 = 50% pumpkin flour and 50% wheat flour, P3 = 75% pumpkin flour and 25% wheat flour. Based on the results of organoleptic tests tested on 20 expert panelists, cookies (P2) got the best score with a score of 316. Within 7 days, the cookie product did not experience any quality degradation. degradation. The total cost required is Rp. 42,650, - while one piece of pastries weighing 25 grams is Rp. 2000.-