bluuebunny/crossref_metadata_2025 huggingface dataset:
Actinides-Centered Borane Molecular Clusters with 24-Coordination Number in the An(BH)24 (An = Th to Cm)
Authors: Hu Shuxian , Zhang Peng , zou wenli , zhang ping
Published: March 2020

Herein we report a new record coordination number of 24 for actinide established in the cage-like An(BH)24 (An = Th to Cm) via using relativistic quantum chemistry methods. Analysis of U(BH)n (n = 1 to 24) confirms these series of systems being as geometric minima, with the BH as a ligand located in the first shell around the uranium. However, our additional global searches reveal the lowest-energy half-cage structure for UB24, which is extended to the series of AnB24 and prevails over the competing structural isomers such as cage. The intrinsic geometric difference for AnB24 and An(BH)24 mainly arise from the B sp3 hybridization in borane inducing strong interactions between An 5f6d7s hybrid orbitals and B 2pz orbitals in An(BH)24 comparing to that of AnB24. The fundamental trend presents a valuable insight for future experimental endeavor searching for isolable complexes with high-coordination actinide and provides a new structural motif of boron clusters and nanostructures.
Pengaruh Capital Adequacy Ratio, Biaya Operasional terhadap Pendapatan Operasional, Loan to Deposit Rasio, dan Non-Performing Loan Terhadap Kinerja Keuangan
Authors: Isramiarsyh A. , Nohong Mursalim , Aswan Andi
Published: March 2020

Penelitian ini bertujuan untuk (1) menganalisis pengaruh Capital Adequacy Ratio (CAR) terhadap kinerja keuangan dan nilai perusahaan. (2) Menganalisis pengaruh Biaya Operasional terhadap Pendapatan Operasional (BOPO) terhadap kinerja keuangan dan nilai perusahaan. (3) Menganalisis pengaruh Loan to deposit ratio (LDR) terhadap kinerja keuangan dan nilai perusahaan. (4) Menganalisis pengaruh Non Performing Loan (NPL) terhadap kinerja keuangan dan nilai perusahaan, serta menganalisis pengaruh kinerja keuangan terhadap nilai perusahaan. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kuantitatif. Populasi dalam penelitian ini adalah perusahaan Industri Perbankan yang tercatat di Bursa Efek Indonesia. Teknik penentuan sampel yang digunakan adalah purposive sampling. Teknik analisis data yang digunakan adalah analisis kualitatif, uji asumsi klasik, analisis jalur (Path analysis) serta pengujian hipotesis. Hasil penelitian bahwa rasio kecukupan modal (CAR) berpengaruh positif dan tidak signifikan terhadap kinerja keuangan (ROA), dimana semakin tinggi rasio kecukupan modal maka laba yang dicapai meningkat. Sedangkan rasio kecukupan modal berpengaruh positif dan signifikan terhadap nilai perusahaan, karena semakin tinggi kecukupan modal maka nilai perusahaan meningkat. Rasio Loan to Deposit Ratio (LDR) berpengaruh positif dan tidak signifikan terhadap kinerja keuangan (ROA), dimana semakin tinggi kiredit yang disalurkan maka laba yang dicapai oleh perusahaan akan meningkat. Begitu pula LDR berpengaruh positif dan signifikan terhadap nilai perusahaan, karena semakin tinggi kredit yang tersalurkan maka pendapatan bunga akan meningkat. Rasio Non Performing Loan (NPL) berpengaruh negatif terhadap kinerja keuangan (ROA), dimana semakin tinggi penanganan kredit bermasalah (diragukan, kurang lancar dan macet) maka laba yang dicapai akan menurun. Sedangkan NPL berpengaruh negatif dan signifikan terhadap nilai perusahaan, karena semakin tinggi kredit bermasalah maka akan menurunkan nilai perusahaan dan hal ini akan mempengaruhi perusahaan investor untuk menanamkan sahamnya pada perbankan.
The Effect of Work-Life Balance and Burnout on Employee Job Satisfaction
Authors: Iswardhani Indri , Brasit Nurdin , Mardiana Ria
Published: March 2020

The balance of work-life balance and burnout on employee job satisfaction both directly and directly carried out on employees of the Deputy Health BPJS Office in South Sulawesi, West Sulawesi, Southeast Sulawesi, and Maluku. This study uses quantitative variables that investigate the position of the variables proposed and the relationship between one variable with another variable. This research is to test hypotheses that have been formulated previously. This study will explain the causal relationship between variables through hypothesis testing. In this study, the analytical method used is path analysis with an analytical path using the Smart PLS 3.2.8 program. The results of this study found that work-life balance has a positive and significant effect on employee job satisfaction, burnout has a negative and significant effect on employee job satisfaction, a positive work-life balance and a significant effect on employee job satisfaction if mediated by burnout.
Analysis of the Financial Performance of PT Garuda Indonesia from the Period 2012 to 2018
Authors: Priyadi Aswin , Maupa Haris , Rasyid Wahda
Published: March 2020

Commercial aviation is a part of aviation industry which specializes in operating aircraft for passenger and cargo. PT Garuda Indonesia is a one flag carrier that has a worldwide reputation in aviation industry. This study analyzes the financial performance of the Indonesian aviation industry, with specific reference to the PT. Garuda Indonesia, Tbk for the period 2012-2018. This research uses descriptive type of research. The data required in this research is collected based on secondary data. The financial performance has been explored to support this study by analyzing the financial statements throughout 2012-2018. The data collected from the company’s prospectus, annual reports, and other sources to help the researcher to analyze the financial performance. The financial ratios which are used in this research are liquidity ratio, profitability ratio, and solvency ratio to determine the financial performance each year. Continue using DuPont Analysis, Compound Annual Growth Method (CAGR), and Optimal Capital Structure and SWOT Analysis. In the last 5 years PT. Garuda Indonesia experience once significant performance degradation in 2014, where the number of total operating expenses were higher than the total operating revenues. It was found that Garuda Indonesia currently suffering from high loss.  A significant change is noticed in 2014 where net income fell up to 90%. In 2017 Garuda Indonesia also suffering too, which is the profit loss till US $ 213 million. This means the net income was not able to cover its expenses at that time. This event is occurred due to the rising domestic jet fuel price and depreciation of Indonesian local currency. The result of this analysis will be given to PT. Garuda Indonesia, Tbk. to improve the financial performance of the company and can be used as a reference for other airline to study financial performance of other airlines.
Qualitative Research of High Performance Work Systems in Automotive Group in South Sulawesi
Authors: Dewantara I Wayan Gede Suharta , Troena Eka Afnan , Haerani Siti , Hamid Nurdjanah
Published: March 2020

Although there are often family businesses or family-based companies in Indonesia, qualitative researches on this topic, linked to leadership and high-performance work systems, are still very rare. For this reason, the goal of the research is to find out how transformational leadership and high-performance work systems are used in the company's day-to-day operations to achieve the company's performance results. This study was conducted in a group of family business companies in South Sulawesi. The company group has an agenda to deliver the best corporate values, including leadership practices and high-performance work systems. With the help of the questionnaires distributed in the company environment, 3000 responses were received and treated with content analysis. The encoding processes in the text analysis revealed that the company has implemented transformation management with the highest level of visibility, strategy, and performance. For a high-performance work system, the company has done well and is less dependent on enterprise management and managers can use the results of this research to improve management practices and high-performance work systems that are better for employees.
The Effect of Leadership Style and Organizational Culture on Employee Performance Through Job Satisfaction as an Intervening Variable at Telkom Indonesia Regional VII Division
Authors: Himawan Ilham , Taba Idrus , Reni Andi
Published: March 2020

This study aims to determine the relationship of leadership style and organizational culture on employee performance through job satisfaction as intervening variables in Telkom Indonesia Regional VII Division. The population of the study is based on managerial & staff job positions consisting of 62 respondences from 161 full-time employees of Indonesia state-owned telecommunication company, Telkom Indonesia Regional VII Division. This research used quantitive methods. The primary data were collected by the questionnaire as the instrument to prove the results of the study. By using Smart Partial Least Squares (PLS), the analysis of collected data revealed and to test the hypotheses. According to the findings of this research supported the positive effect of leadership style, organizational culture, and job satisfaction through employee performances. The hypotheses analysis in the study has no significant effect of leadership style on employee performance, whereas job satisfaction as partial mediating.
Effect of Dual Role Conflict Work Family Conflict, Workload, and Job Stress on the Employee Performance of PT. Bank Negara Indonesia (Persero) Tbk at Bank Branch Pare-Pare
Authors: Samsinar Samsinar , Hamid Nurdjanah , Rasyid Wahda
Published: March 2020

This study aims to determine the effect of multiple role conflict (work-family conflict, workload and work stress on the performance of female employees of PT. Negara Negara Indonesia (Persero) Pare-pare. The type of data collected is in the form of quantitative and qualitative data. The population of this study was all employees of the PT. Bank Negara Indonesia Branch of Pare-pare who were married and had as many as 36 children. Sampling technique uses purposive sampling. Data sources used are primary data and secondary data. Data were analyzed using path analysis. The results of this study indicate that multiple role conflict and workload directly influence significantly the work stress of female employees of PT. Bank Negara Indonesia (Persero) Tbk. The relationship between a conflict of dual roles to positive work stress and the relationship between workloads to positive work stress means that an increase in workload can increase the work stress of female employees. Direct work stress also negatively affects the performance of female employees of PT. Bank Negara Indonesia (Persero) Tbk, meaning that when work stress increases, performance will decrease
The Effect of Situational Leadership and Work Ethics on Employee Performance through Organizational Climate as Intervening Variables at Gowa Agricultural Development Polytechnic
Authors: Esiana Tangdigling Delia , Nursyamsi Idayanti , Mardinana Yusuf Ria
Published: March 2020

This study aims to determine the effect of Situational Leadership and Work Ethics on Employee Performance through Organizational Climate as an Intervening Variable in Gowa Agricultural Development Polytechnic. The type of data used in this study is divided into two, namely qualitative and quantitative data. The population in this study were all State Civil Apparatus at the Gowa Agricultural Development Polytechnic, which until 2018 totaled 98 people. A sample of 98 employees based on the population. The sampling technique used is the nonprobability sampling method. Data collection techniques used were observation, interviews, questionnaires, and documentation. Data were analyzed using path analysis. The results of this study indicate that situational leadership has a positive and significant effect on organizational climate. The better the leader applies situational leadership, the better the climate for the organization will be and conducive. Good situational leadership will create a good organizational climate so that it will have an impact on increasing employee performance. Work ethic has a positive and significant effect on organizational climate. The better the work ethic that is owned by employees, it will support the creation of a good organizational climate. The better the work ethic that is owned by an employee it will lead to a good organizational climate, which has an impact on increasing employee performance.
Determinants of the Performance of Small and Medium Enterprises (SMES) in Barru District
Authors: Khaerunnisa Khaerunnisa , Jusni Jusni , Pono Maat
Published: March 2020

This study aims to determine the Determinants of the Performance of Small and Medium Enterprises (SMEs) in Barru Regency. The method used in this study is a quantitative approach and the type of research conducted is survey research. The population used is Small and Medium Enterprises in the manufacturing industry sector in Barru Regency, which is 1672 business units. The number of samples is 94 small and medium enterprises. The data sources used are primary data and secondary data. Analysis of the data used is multiple linear regression analysis. The results of this study indicate that the aspects of finance, environment, marketing, human resources, entrepreneurial ability and economic aspects have a positive and significant effect on the performance of small and medium enterprises in Barru Regency. The greater the equity, loan capital, the level of profits and capital accumulation, the greater the performance of small and medium enterprises. The better the technology and quality control, the availability of business places, government policies, seasons and infrastructure, the better the performance of small and medium enterprises. The more market demand, the better competing pricing, promotion, distribution channels and marketing areas, the better the performance of small and medium enterprises. The better the level of formal education, leadership, experience in business and the amount of motivation and skills in the performance of small and medium enterprises. The greater the desire for achievement, personal responsibility, management ability and innovation ability, the better the performance of small and medium enterprises. the higher the level of income of the community, the availability of jobs, a business climate and good investment and the better the economic growth, the better the performance of small and medium enterprises.
The Application of the Balanced Scorecard as a Method of Implementing Strategies in an Effort to Improve the Performance of the University of Timor
Authors: Bria Seran Rikhardus , Randa Payangan Otto , Sumardi Sumardi
Published: March 2020

This study aims to find out Knowing 1) the application of balance scoreCard by translating the vision, mission of the University of Timor based on four perspectives, 2) Measuring the performance of the University of Timor based on the balanced scorecard perspective. This research is qualitative research. The sample in this study was 316 respondents consisting of lecturers, students and alumni of the University of Timor and using random sampling techniques. Data were analyzed by qualitative analysis methods. The results of the study show that translating vision and mission into four perspectives (financial, customer, internal business and growth and learning) results in a balanced scorecard design which is a proposed work program at the University of Timor. While performance measurement uses four perspectives on the balanced scorecard; the customer's perspective according to students reaches 2716 points is categorized as not good. 1711 points for the lecturer's internal business perspective are said quite well. 1004 points for the perspective of growth and learning of lecturers are quite well. 1800 points for the growth and learning perspective of administrative staff are categorized quite well. 541 points for the financial perspective of University of Timor officials are also categorized quite well
THE FACTORS AFFECTING THE SATISFACTION OF THE SERVICE USERS AT PERTIWI MOTHER AND CHILD RSKD
Authors: Zaenab Sitti
Published: March 2020

This research aimed to investigate the effect of the service quality, facilities, and location on the satisfaction of the service users at Pertiwi Mother and Child RSKD. The research used the Regression Equation. The objects researched on were the 160 users of Pertiwi Mother and Child RSKD, who were chosen using the incidental sampling technique. The data were collected using the technique of distributing questionnaires to the patients as the users of the services at Pertiwi Mother and Child RSKD. The research results indicated that the service quality, tariff, facilities and location had a positive and significant effect on the satisfaction of the service users.
ANALISIS REBRANDING UNTUK MEMBENTUK FAVORABLE BRAND IMAGE PADA RADIO PLAY 99ers
Authors: Indika Deru R , Dewi Windy Utami
Published: March 2020

Penelitian ini membahas hasil analisis pelaksanaan rebranding pada “Play 99ers” Radio Bandung. Tujuan penelitian untuk mengetahui mengenai pelaksanaan rebranding dan keputusan perusahaan untuk melakukan rebranding  termasuk keputusan yang tepat atau tidak. Faktor pendorong perusahaan melakukan rebranding adalah karena pergantian kepemilikan, pelaksanaan rebranding yang dilakukan oleh perusahaan adalah mengubah positioning, nama, desain logo, dan cara komunikasi. Dimensi pengukuran analisis rebranding yang digunakan dalam penelitian ini yaitu brand repositioning, brand renaming, brand redesigning dan brand relaunching.Metode penelitian yang digunakan dalam penelitian ini adalah survey dengan metode deskriptif. Teknik pengumpulan data yang digunakan adalah studi kepustakaan, observasi, dan kuesioner. Sampel diambil dari 100 orang responden yang pernah mendengarkan “Play 99ers” Radio Bandung yang diambil dengan menggunakan teknik purposive sampling. Hasil penelitian menunjukkan rebranding yang dilakukan merupakan keputusan yang tepat karena mendapat tanggapan baik dari masyarakat.
PENGARUH E-SERVICE QUALITY TERHADAP E-SATISFACTION PADA PELANGGAN SITUS TOKO ONLINE BRODO
Authors: Ashoer Muhammad
Published: March 2020

Perkembangan pesat pasar online selama beberapa tahun terakhir telah mengundang perhatian banyak pihak, khususnya para ahli pemasaran. Banyak perusahaan e-commerce yang berhasil mencetak laba melalui peningkatan kualitas layanan elektronik (e-service quality), namun sebagai entitas bisnis yang berorientasi pada kepuasan pelanggan online masih terdapat inkonsistensi dan berbagai macam permaslahan yang diungkap pada beberapa penelitian terdahulu sehingga dibutuhkan pengujian lanjutan. Penelitian ini mencoba menganalisis pengaruh e-service quality terhadap e-satisfaction dengan mengukur persepsi pembeli terhadap toko online fashion khusus laki-laki; Brodo. Penelitian ini menggunakan pendekatan kuantitatif, dan proses pengumpulan data primer dilakukan dengan cara penyebaran angket secara online kepada pelanggan Brodo yang telah melakukan transaksi minimal 1 (satu) kali. Jumlah sampel yang memenuhi kriteria sebanyak 121 responden berdasarkan teknik purposive sampling. Teknik analisis data menggunakan regresi linier sederhana. Hasil penelitian menunjukkan bahwa e-service quality berpengaruh positif dan signifikan terhadap e-satisfaction pelanggan pada toko online Brodo.Kata kunci: E-service quality, E-satisfaction, E-commerce, Marketing Management.
ANALISIS DANA ALOKASI KHUSUS TERHADAP PERTUMBUHAN EKONOMI DAN INDEKS PEMBANGUNAN MANUSIA DI PROVINSI SULAWESI SELATAN
Authors: Amir Ismayani
Published: March 2020

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh DAK bidang pendidikan terhadap indeks pembangunan manusia (IPM) secara langsung atau melalui pertumbuhan ekonomi pada kabupaten/kota di Provinsi Sulawesi Selatan; pengaruh DAK bidang kesehatan terhadap indeks pembangunan manusia (IPM) secara langsung atau melalui pertumbuhan ekonomi pada kabupaten/kota di Provinsi Sulawesi Selatan; pengaruh DAK bidang lain-lain terhadap indeks pembangunan manusia (IPM) secara langsung atau melalui pertumbuhan ekonomi pada kabupaten/kota di Provinsi Sulawesi Selatan;dan pengaruh pertumbuhan ekonomi terhadap indeks pembangunan manusia (IPM) pada kabupaten/kota di Provinsi Sulawesi Selatan. Data yang digunakan dalam penelitian ini adalah data sekunder, yaitu data yang diperoleh dari Dirjen Perimbangan Keuangan Pemerintah Daerah (DJPKD) dan Badan Pusat Statistik (BPS). Jenis data yang digunakan adalah pooled data (data panel) yang merupakan gabungan data time series yaitu tahun 2010 sampai 2016 dan data cross section yaitu 24 kabupaten/kota, dengan menggunakan analisis regresi data panel dengan bantuan program Eviews 9. Hasil penelitian menunjukkan bahwa: Pertama, DAK bidang pendidikan secara langsung berpengaruh signifikan terhadap IPM dan secara tidak langsung pengaruh DAK bidang pendidikan terhadap IPM dapat dimediasi melalui pertumbuhan ekonomi. Kedua, DAK bidang kesehatan secara langsung berpengaruh signifikan terhadap IPM dan secara tidak langsung pengaruh DAK bidang kesehatan terhadap IPM dapat dimediasi melalui pertumbuhan ekonomi. Ketiga, DAK bidang lain-lain secara langsung berpengaruh signifikan terhadap IPM dan secara tidak langsung pengaruh DAK bidang lain-lain terhadap IPM dapat dimediasi melalui pertumbuhan ekonomi. Keempat, pertumbuhan ekonomi berpengaruh signifikan terhadap IPM. Kata kunci: Dana alokasi khusus (DAK) bidang pendidikan, kesehatan, lain-lain, pertumbuhan ekonomi, IPM, Sulawesi Selatan.
KEPERCAYAAN DAN KOMITMEN DALAM PERSPEKTIF FRANCHISEE PADA WARALABA LOKAL AYAM GORENG DI MAKASSAR
Authors: Rusman Rusni Fitri Y. , Azhar Muhammad
Published: March 2020

Salah satu usaha waralaba yang banyak ditemukan di kota Makassar adalah waralaba lokal ayam goreng. Selain bahan baku yang mudah didapat, pengolahan ayam goreng cukup mudah serta diminati konsumen. Tujuan dari penelitian adalah untuk melihat variabel kepercayaan dan komitmen mampu membantu dalam membangun hubungan antara franchisor dan franchisee. Variabel kepercayaan dan komitmen ini dijabarkan dalam beberapa dimensi yang kemudian dijelaskan dalam beberapa indikator. Dimensi variable kepercayaan yaitu kelengkapan outlet/gerai, cara penjelasan kontrak, pemberian hadiah, komunikasi serta hal yang dibicarakan dalam komunikasi. Dimensi variable komitmen yaitu sikap franchisor, waktu pembayaran bahan baku, cara pembayaran, waktu penerimaan bahan baku serta dukungan franchisor terhadap pendapat franchisee. Populasi dalam penelitian ini adalah pemilik dari usaha waralaba ayam goreng BFC, C’Bezt Fried Chicken dan Quick Fried Chicken. Teknik pengambilan sampel menggunakan metode sensus dimana semua populasi franchisee dari ketiga merek tersebut. Namun, hanya 52 orang franchisee yang bersedia diwawancarai menggunakan kuisioner dari ketiga merek waralaba tersebut. Hasil penelitian memperlihatkan bahwa dimensi komunikasi pada variable kepercayaan merupakan dimensi yang paling penting untuk diperhatikan dalam menumbuhkan kepercayaan franchisee terhadap franchisor sedangkan untuk variable komitmen, dimensi sikap franchisor merupakan yang paling penting diantara keempat dimensi lainnya.
ANALISIS SENTIMEN REVIEW APLIKASI RUANGGURU MENGGUNAKAN ALGORITMA SUPPORT VECTOR MACHINE
Authors: Irfani Faizal Fakhri
Published: March 2020

Analisis sentiment review aplikasi Ruangguru merupakan proses menganalisa, memahami dan mengklasifikasikan suatu penilaian yang dikeluarkan masyarakat terhadap entitas aplikasi Ruangguru. Data penelitian ini diambil dari website google play store, data yang diambil yaitu data teks review dengan jumlah 2000 review. Data diklasifikasikan dengan menggunakan algoritma Support Vector Machine, dan dilakukan pengujian menggunakan kombinasi dari pembagian data latih dan data uji, serta menggunakan sistem K-Fold Cross-Validation. pengujian menggunakan kernel linear menghasilkan akurasi tertinggi dengan nilai 0.897. kombinasi data training 60% dan data testing 40% menghasilkan akurasi tertinggi sebesar 0.900. Pengujian dengan menggunakan sistem k-fold, akurasi tertinggi berada di nilai k-fold 6, 9, dan 10 dengan nilai akurasi sebesar 0.902. Namun pada k-fold 10, tingkat presisi nya lebih tinggi dibanding nilai k-fold lainnya dengan nilai presisi sebesar 0.903. Tingkat akurasi dalam penelitian ini tinggi berada di kisaran 90%. Hasil dari beberapa pengujian menunjukan bahwa sentimen masyarakat terhadap aplikasi Ruangguru cenderung positif.
¿La incorporación de residuos de diferentes especies de Lupinus, como abono verde, afecta la actividad microbiana del suelo?
Authors: Zapata Hernández Isidro , Zamora Natera Juan Francisco , Trujillo Tapia Ma Nieves , Ramirez Fuentes Eustacio
Published: March 2020

In the state of Jalisco, corn and tequila agave are the most important agricultural crops. The soils to cultivate these species are characterized by low content of organic matter and nitrogen. The amendments applied to the soil provide an important source of energy and nutrients for microorganisms; promotes the diversity of nitrogen-f ixing bacteria and nitrifying bacteria, which increases nitrogen availability in the soil. The aim of this study was to evaluate the use of two species of wild legumes: Lupinus exaltatus and Lupinus rotundiflorus as green manure (AV), and its effect on soil microbial biomass. An aerobic incubation experiment (14 days) was carried out on soil samples with green manure and without green manure (control). Under laboratory conditions, the microbial activity of soil was monitored through the response in basal respiration and the concentration of C and N in the microbial biomass. The CO2 production and C and N content in the microbial biomass showed significant differences (P < 0.05) due to the effect of green manure. The residues of Lupinus are considered better quality than the residues of Zea mays due to its nitrogen content and low C: N ratio. The response of microorganisms presented a positive primer effect with the input of AV. Therefore, we conclude that the input of L. exaltatus and L. rotundiflorus as a green manure to the soil increases the biological activity of the soil and promotes the enrichment of C and N of the microbial biomass.
Efectos de medicamentos homeopáticos en indicadores fisiológicos y del desarrollo inicial del frijol Yorimón (Vigna unguiculata L., Walp.)
Authors: Mazón Suástegui José Manuel , Ojeda Carlos Michel , García Bernal Milagro , Batista Sánchez Daulemys , Gurrola Mesa Alonso Daniel , Mesa Zavala Erika
Published: March 2020

Homeopathic medicine is a discipline of universal medical science, with increasing application in humans, animals and plants. The acceptance of agricultural homeopathy is increased by the safety and proven effectiveness of its ultra-diluted and agitated medicines, to stimulate the germination, development, growth and production of various plant species. The present work aimed to evaluate the effect of homeopathic medicines on physiological indicators and the development of Yorimón beans (Vigna unguiculata L., Walp.) var. Paceña. A completely randomized design was used with two homeopathic treatments, Manganum metallicum 31CH (MnM-31CH), Magnesium-manganum phosphoricum 3CH (MaMnP-3CH) and as a control treatment destilled water (DW), with six replicas per treatment. Photosynthetic rate, perspiration, total chlorophyll, leaf area and fresh and dried biomass of root, stem and leaves were evaluated. An analysis of variance was applied and when there was a signif icant difference between treatments, a comparison of means (Tukey HSD, P ≤ 0.05). The results revealed a signif icant increase for all the variables evaluated with respect to the control treatment (DW), in the plants that received treatments (MnM-31CH and MaMnP-3CH). Fresh root biomass was the response variable with the highest percentage increase (111.2%) and was recorded in the plants treated with MnM-31CH, compared to the plants in the control group, without medication (DW). Likewise, in the treated plants (MnM-31CH and MaMnP-3CH) there was an increase greater than 40% in total chlorophyll and in photosynthesis. This conf irms the effectiveness of applied treatments and reveals potential of agricultural homeopathy, as an alternative to achieve greater eff iciency in the cultivation of V. unguiculata.
La Homeopatía incrementa la tolerancia al estrés por NaCl en plantas de frijol común (Phaseolus vulgaris L.) variedad Quivicán
Authors: Mazón Suástegui José Manuel , Ojeda Silvera Carlos Michel , García Bernal Milagro Ramona , Batista Sánchez Daulemys , Abasolo Pacheco Fernando
Published: March 2020

Currently, the international scientif ic community is increasingly promoting the use of alternatives eco-friendly to the environment to solve agricultural problems, such as soil salinization. The use of agricultural homeopathy, as one of these alternatives, has increased because of its safety and proven effectiveness. This study assessed the effect of attenuating salinity stress (NaCl) of the homeopathic medicine Natrum muriaticum (NaM) on photosynthetic rate (TF) and morphometric variables of the common bean plant (Phaseolus vulgaris L.) variety white testa Quivican in initial plant growth stage. A completely randomized experimental design was applied with bifactorial arrangement (2A × 4B) where A = salinity levels (0 and 75 mM) and B = homeopathic dynamizations (NaM-7CH, NaM-13CH, NaM-7+13CH and distilled water [AD] as homeopathic control) with f ive replicates per treatment. The TF measurements were done twice a week, and the morphometric variables were measured at the end of the experimental evaluation period (35 days). In general, the assessed morphometric variables were favored with the application of the homeopathic treatments NaM 7CH and NaM 7+13CH; the increase in root length (LR) and fresh leaf biomass (BFH) were greater even when the plants were in salinity stress conditions (75mM NaCl). The TF reached the highest value when the plants in saline medium were treated with NaM-7CH, and an increase greater than 50% in PR was observed with respect to the (AD) control treatment. These results demonstrated a great potential of agricultural homeopathy as a bio-safe and low-cost alternative to increase P. vulgaris L.  tolerance to NaCl and achieve greater areas of this crop.
Efecto de medicamentos homeopáticos en plantas de tomate (Solanum lycopersicum L.)
Authors: Abasolo Pacheco Fernando , Bonilla Montalván Boris , Bermeo Toledo Cesar , Ferrer Sánchez Yarelys , Ramirez Castillo Andy Jafet , Mesa Zavala Erika , Mazón Suástegui José Manuel , Llerena Ramos Luis
Published: March 2020

Agrochemical use in horticultural cultivations generates negative effects, thus the need for searching to decrease or eliminate its use by means of other less toxic techniques. Agricultural homeopathy represents an alternative for ecological agriculture, impacting positively in cultivation development. The effect of four homeopathic medicines for human use were assessed in two centesimal dynamizations (7CH and 13CH) [(Silicea Terra (SiT), Natrum muriaticum (NaM), Zincum phosphoricum (ZiP) and Phosphoricum acidum (PhA)], and a control treatment (distilled water) on tomato plant germination, emergence, and initial development. The treatments were established under a randomized complete block design with three repiclates. Germination and emergence rate and percentage and morphometric variables (plant height, radicle length, dry and wet weight) were assessed, including the variables in stem diameter and wet and dry leaf weight, number of branches, leaves, and buds in the vegetative development stage. Signif icant differences were observed in all the morphometric variables assessed in function of the different development stages, homeopathic medicines, and their different dynamizations. During germination, greater growth in stem length was observed with ZiP-7CH (5.5 ± 0.98 cm) compared to the control group (4.3 ± 1.10 cm). During the emergence stage, the treatments SiT-7CH (6.6 ± 1.11 cm) and ZiP-7CH (5.9 ± 1.41 cm) increased stem length signif icantly whereas with PhA-7CH, the best effects were obtained in the variables assessed during the vegetative development stage, LT (94 ± 8.31 cm), leaf number (No hojas) (131 ± 27.71), fresh stem biomass (BFT) (17.20 ± 2.45 g), wet leaf biomass (BFH) (30 ± 7.72 g), dry leaf biomass (BSH) (2 ± 0.61 g), fresh root biomass (BFR) (10 ± 6.26 g), dry root biomass (BSR) (1 ± 0.43 g), and number of flower buds (No H) (6 ± 7.10). The homeopathic medicines applied impacted positively during the initial and vegetative development stages of tomato under controlled conditions. This research study represents and advance in the sustainable management of tomato cultivation.
Heavy Metal Removal Investigation in Conventional Activated Sludge Systems
Authors: Buaisha Magdi , Balku Saziye , Yaman Şeniz Özalp
Published: March 2020

The combination of industrial and domestic wastewater in municipal WWTPs (waste water treatment plants) may be economically profitable, but it increases the difficulty of treatment, and also has some detrimental effects on the biomass and causes a low-quality final effluent. The present study evaluates the treatment process both in the presence and absence of heavy metals using ASM3 (activated sludge model no.3) so as to improve the model by means of incorporating other novel inhibitory kinetic and settler models. The results reveal that the presence of heavy metal, a case study for copper and cadmium at a concentration of 0.7 mgL−1 in a biological treatment system has a negative effect on heterotrophic bacteria concentration by 25.00 %, and 8.76 % respectively. Meanwhile, there are no important changes in COD (chemical oxygen demand), SS (total suspended solids) and TN (total nitrogen) in the final effluent in the conventional system. However, all these parameters are acceptable and consistent with EU Commission Directives. The results indicate that ASM3 can predict and provide an opportunity of the operation for an activated sludge wastewater treatment plant that receives the effluent from an industrial plant.
SALURAN DAN MARGIN PEMASARAN DURIAN HASIL AGROFORESTRI DI DESA SIDODADI
Authors: Prasetya Ari Yudha , Qurniati Rommy , Herwanti Susni
Published: March 2020

Durian is a plant that has high production potential planted by farmers in Sidodadi Village with agroforestry patterns. This production potential can provide benefits for farmers if they are able to be marketed efficiently. The purpose of this study was to analyze the channels and margins of durian marketing in Sidodadi Village, Teluk Pandan District, Pesawaran District, Lampung Province. The study was conducted in January 2019 with the object of research by farmers and durian marketing institutions in Sidodadi Village. Analysis was carried out qualitatively to assess marketing channels and quantitatively to calculate marketing margins. The results showed that marketing of durian in Sidodadi Village consisted of 3 marketing channels and led to the oligopsonistic market structure. The uneven value of marketing margins, profits, and farmer shares has caused the marketing system to be inefficient.
Histamine test kit formation from Manganase (II), 5-fluorouracil and Alizarin red S complex compound
Authors: Sholehah Hijriati , Susane Hismi
Published: March 2020

This researh aims to detect the presence of histamine by forming complex compounds of 5-fluorouracil, Mn (II) metal ions and alizarin red S reagents. This type of research is a laboratory experiment. This research was conducted at the Ikip Chemistry Laboratory in 2019. The results showed that the Test Kit that was made could be used to detect the presence of histamine determining the existence of histamine qualitatively viewable color formed based on complex compounds ofÃÂ  Mn(II)-His-5FU-ARS seen from the shift in wavelength of maximum generated.. The making of the histamine test kit is made by varying the concentration of 10-100 ppm at 10 ppmÃÂ ÃÂ  intervals under optimum conditions and can be used to make a color comparator solution. ThenÃÂ  the method validity test is done by making a standard histamine curve that gives a regression equationÃÂ  y = 0.001x + 0.3364 with a correlation coefficient (r2) = 0.9972. Based on the validity test method, the accuracy value is in the range ofÃÂ  95.0-106% and the results of the test kit on tuna samples indicate that the histamine test kit made has a good accuracy value because the average recovery value is 96%.ÃÂ
Penerapan Metode Problem Based Learning Untuk Meningkatkan Hasil Belajar Biologi Mata Pelajaran Lintas Minat
Authors: Ilhamdi Mohammad Liwa , Santoso Didik , Astuti Sri Prapti
Published: March 2020

Penelitian ini bertujuan untuk menerapkan metode problem based learning untuk meningkatkan hasil belajar Biologi siswa kelas X IPS Unggulan ÃÂ tahun 2018-2019. Jenis penelitian ini adalah penelitian tindakan kelas (PTK). ÃÂ Variabel tindakan dalam penelitian ini adalah metode problem based learning sedangkan variabel harapannya adalah hasil belajar biologi. ÃÂ SubyekÃÂ  dalam penelitian ini adalah siswa kelas X IPS Unggulan MAN 2 Mataram berjumlah 37 orang. Penelitian berlangsung 2 siklus. Masing-masing siklus terdiri dari tahap perencanaan, pelaksanaan, observasi dan refleksi. Instrumen yang digunakan dalam penelitian ini adalah ÃÂ lembar observasi dan lembar tes. Hasil penelitian menunjukkan bahwa pada siklus I ÃÂ kegiatan ÃÂ pembelajaran problem based learning yang dilakukan guru memperoleh skor 12 kategori cukup baik, aktivitas siswa kategori cukup aktif sedangkan ketuntasan belajar klasikal 78,3% kategori belum memenuhi KKM. Pada siklus ke II skor kegiatan ÃÂ guru memperoleh skor 17 ÃÂ kategori baik, aktivitas siswa memperoleh skor 13 kategori aktif dan ketuntasan klasikal 86%. Kesimpulan penelitian ini adalah penerapan metode problem based learning dapat meningkatkan hasil belajar Biologi siswa kelas X IPS Unggulan MAN 2 Mataram tahun pelajaran 2018-2019.
3.3 Age- and Sex-specific Reference Intervals for Brachial Artery Flow-mediated Dilation in Healthy Individuals and the Relation with Cardiovascular Risk Factors
Authors: Holder Sophie , Bruno Rosa Maria , Shkredova Daria , Thompson Andrew , Dawson Ellen , Jones Helen , Hopkins Nicola , Hopman Maria , Bailey Tom , Coombes Jeff , Askew Christopher , Naylor Louise , Maiorana Andrew , Ghiadoni Lorenzo , Green Daniel , Thijssen Dick
Published: March 2020

Background

Assessment of endothelial function using brachial artery flow-mediated dilation (FMD) predicts future cardiovascular disease (CVD) risk. However, poor adherence to protocol guidelines and lack of reference values hinders widespread FMD use. This study established age- and sex-specific reference intervals for brachial artery FMD in healthy individuals and examined the relation with CVD risk factors.

Methods

Collected according to expert-consensus guidelines, we combined brachial artery FMD and subject characteristics/medical history from 5,362 individuals (4–84 years; 2,076 females). We first examined healthy individuals (n = 1,403 [582 females]) to generate age-/sex-specific percentile curves. Subsequently, we included subjects with CVD risk factors but without disease (un-medicated n = 3,167 [1,247 females], and medicated n = 792 [247 females]). Multiple linear regression tested the relation of CVD risk factors with FMD.

Results

Healthy men showed a negative, curvilinear relation between FMD and age, whilst females revealed a linear relation that started higher, but declined at a faster rate. Age-/sex-related differences in FMD, at least partly, relate to baseline artery diameter. FMD was affected by CVD risk factors in un-medicated (e.g. systolic-/diastolic blood pressure, diabetes) and medicated subjects (e.g. dyslipidaemia). Importantly, sex mediated these effects (p < 0.05), with (supra) normalisation of FMD in medicated men, but not in women (except for blood pressure).

Conclusion

Sex alters the age-related decline in FMD, which is partly explained through differences in artery diameter. Sex also altered the effect of some CVD risk factors and medication on FMD. This work improves interpretation and future use of the FMD technique when strictly adhering to FMD protocol guidelines.
3.6 Fitness, Fatness and Exercise Blood Pressure in Adolescence
Authors: Huang Zhengzheng , Park Chloe , Chaturvedi Nishi , Howe Laura , Sharman James , Hughes Alun , Schultz Martin
Published: March 2020

Objective

Exaggerated exercise blood pressure (BP) is associated with cardiovascular risk factors in adolescence. Aerobic fitness and adiposity (fat mass or ‘fatness’) are important independent contributors to cardiovascular risk in adolescence, but their interrelated associations with exercise BP are unknown. The aim of this study was to determine the respective relationship between fitness, fatness and exercise BP in a large birth cohort of adolescents.

Methods

2356 adolescents from the Avon Longitudinal Study of Parents and Children (aged 17.8 ± 0.4 years, 38.5% male) completed a submaximal exercise step-test that allowed fitness (VO2max) to be determined from workload and heart rate using a validated equation. Exercise BP was measured immediately on test cessation and fatness calculated as the ratio of total fat mass to total body mass measured by DXA.

Results

Exercise systolic BP decreased stepwise with each tertile of fitness (146 [144, 147]; 142 [141, 144]; 141 [139, 142] mmHg), but increased with each tertile of fatness (137 [135, 138]; 143 [142, 144]; 148 [147, 149] mmHg). In separate models, fitness and fatness were independently associated with exercise systolic BP after adjustment for sex, age, height, smoking and socioeconomic status (standardised β : −1.97, 95% CI: −2.90, −1.04 mmHg/SD and 5.69, 95% CI: 4.61, 6.77 mmHg/SD respectively). However, when fitness and fatness were included in the same model, only fatness remained independently associated with exercise BP (6.15, 95% CI: 4.88, 7.41 mmHg/SD).

Conclusion

Both fitness and fatness are associated with exercise BP in adolescence. However, the fitness-exercise BP association was not independent of fatness, suggesting fatness accounts for the association with exercise BP.
5.4 Acute Effects of Indapamide Treatment on Haemodynamics and Glycosaminoglycan-Mediated Non-Osmotic Skin Sodium Storage in Healthy Humans
Authors: Connolly Kathleen , Selvarajah Viknesh , McEniery Carmel , Wilkinson Ian
Published: March 2020

Introduction

The skin may protect against the adverse haemodynamic effects of dietary salt by storing excess sodium in an osmotically inactive form, bound to glycosaminoglycans. However, this novel pathway has not been comprehensively studied in humans.

Methods

85 healthy volunteers (37 m, 48 f) <50 years of age underwent a one-week run-in to standardise dietary salt intake, before random allocation to either placebo or 2.5 mg indapamide diuretic for eight days. Total body water (TBW), peripheral blood pressure, pulse wave velocity (PWV), stroke volume (SV), cardiac output (CO), and skin biopsies were taken before and after treatment. PWV was measured using SphygmoCor, while SV and CO were measured by inert gas rebreathing. 5 mm skin biopsies were taken from the lower back using sodium-free lignocaine. Biopsies were freeze-dried to establish water content, and sodium content was quantified using inductively coupled plasma — optical emission spectroscopy. Glycsosaminoglycan content was assessed by qPCR. Data were analysed using repeated measures ANOVA.

Results

Following indapamide treatment, skin sodium fell by 10% (p = 0.004) with no reduction in skin water content, compared to placebo. There were no significant differences in blood pressure or PWV between groups. TBW, SV, and CO were significantly reduced by indapamide compared to placebo (p < 0.001, p < 0.01, p < 0.01, respectively), whilst systemic vascular resistance increased (p < 0.001). Glycosaminoglycan mRNA expression decreased (p < 0.05).

Conclusion

This diuretic-induced reduction in skin sodium content and glycomsaminoglycan expression, without commensurate water loss, suggests a release of sodium from osmotically inactive skin stores. This is the first comprehensive evidence of glycosaminoglycan-regulated non-osmotic skin sodium storage in humans, with implications for salt-sensitive hypertension.
P2 Calcium Induced Intramitochondrial cAMP Signalling Enhances Aldosterone Secretion
Authors: Szanda Gergő , Wisniewski Éva , Rajki Anikó , Spät András
Published: March 2020

Elevation of plasma [K+] and [angiotensin II] (Ang II), two major physiological stimuli of adrenal zona glomerulosa cells, increase aldosterone production by triggering cytosolic Ca2+ signalling. Cytosolic Ca2+ signals are accompanied by mitochondrial Ca2+ elevations which further strengthen this steroidogenic response. It has recently been recognized that such mitochondrial Ca2+ signals activate the mitochondrial soluble adenylyl cyclase (sAC) thus evoking intramitochondrial (matrix) cAMP elevations during Ca2+ signalling. We hypothesised that this Ca2+ induced mitochondrial cAMP production, too, contributes to the hypersecretion of aldosterone. Using human adrenocortical H295R cells we found that silencing of sAC decreased mitochondrial cAMP production and, at the same time, decelerated Ca2+ accumulation by the organelle. On the other hand, inhibition of the mitochondrial phosphodiesterase (PDE2A) intensified matrix cAMP production and accelerated mitochondrial Ca2+ uptake. More importantly, both pharmacological inhibition and knock-down of sAC mitigate AngII-induced aldosterone production. Finally, overexpression of wild-type sAC within the mitochondrial matrix increased mitochondrial cAMP formation, accelerated mitochondrial Ca2+ uptake and, most prominently, potentiated aldosterone production as compared to the enzymatically inactive mutant enzyme. Altogether, Ca2+-induced mitochondrial cAMP signalling supports aldosterone production by favouring additional Ca2+ influx into the organelle. This positive feed-back loop may expedite the hormonal response when immediate hypersecretion of mineralocorticoids is crucial for cardiovascular compensation (e.g. exsiccation, blood loss).
P3 Factor Influencing Endothelial Function in Type 2 Diabetes Mellitus with Newly Diagnosed Hypertension
Authors: Srivastava Prachi
Published: March 2020

Background

Increased risk for cardiovascular diseases is associated with diabetes, can be partially attributed to endothelial dysfunction. However, the cumulative factors leading to endothelial dysfunction in Type 2 DM are not clear. In the current study, a novel attempt was made to understand factors influencing endothelial function (EF) in humans using Angiotensin Converting Enzyme (ACE) inhibition as a tool to alter EF.

Methods

Brachial Flow-mediated-dilation (FMD) was measured using ultrasonography in 60 diabetics with newly-diagnosed hypertension. Serum E-selectin, Vascular-Cell-Adhesion-Molecule-1 (VCAM-1), hsCRP, IL-10, Renin, Ang 1–7, Ang II and ACE 2 were measured using ELISA. Amplitude of change, calculated as absolute difference in values obtained at baseline (V1) from those after 3 months (V3) (V3−V1), of biomarkers were correlated with change in FMD and E-selectin after 3 months of ACE inhibition.

Results

FMDV3-V1 showed significant negative correlation with hsCRPV3-V1, FSV3-V1, PPSV3-V1 and HbA1cV3-V1 [(r = −0.3, p = 0.02), (r = −0.31, p = 0.01), (r = −0.27, p = 0.03) (r = −0.3, p = 0.02), respectively] and significant positive correlation with Ang1–7V3-V1 (r = 0.39, p = 0.002). E-selectin correlated positively with FSV3-V1, PPSV3-V1 , HbA1cV3-V1, VCAM-1V3-V1 and ReninV3-V1 [(r = 0.35, p = 0.006), (r = 0.32, p = 0.01), (r = 0.45, p = 0.0005), (r = 0.66, p < 0.001), (r = 0.53, p < 0.0001) respectively].

Conclusion

A balance between the Renin/ Ang II and Ang 1–7/ACE2 axis plays a significant role in EF. Additionally, reduction in blood sugar levels and vascular inflammation also improves EF.