bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Characterisation, Invitro anticancer activity of Diazo Derivatives of 1,3,4-oxadiazole
Authors: Kurup Shilpa S , Jat Rakesh Kumar
Published: October 2023

This study delves into the comprehensive evaluation of newly synthesized Diazo Derivatives of 1,3,4-oxadiazole compounds, including Aniline, Ortho nitro aniline, Meta nitro aniline, Ortho anisidine, Meta anisidine, 3-chloro aniline, 2,6-dimethyl aniline, 2,5- dicloro aniline, and 3,5- dichloro aniline, aiming to unravel their potential as antioxidants and anticancer agents.  The assessment of antioxidant potential involved the utilization of the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. The cytotoxic activity of these compounds was assessed against MCF-7 breast cancer cells using the MTT assay. Morphological assessments using acridine orange/ethidium bromide (AO/EB) staining. Results were expressed as IC50 values, with 2,5-dichloro aniline and 3-chloro aniline demonstrating remarkable antioxidant activity, each with an IC50 value of 62.5 µg/mL. Several other compounds also exhibited significant antioxidant properties, albeit with slightly higher IC50 values. Notably, Ortho anisidine and Ortho nitro aniline displayed no substantial inhibitory activity against oxidative stress. The cytotoxic activity of these compounds was assessed against MCF-7 breast cancer cells using the MTT assay, with IC50 values ranging from 62.5 to 1000 µg/mL. 2,5-dichloro aniline and 3-chloro aniline emerged as potent inhibitors, both achieving an IC50 value of 62.5 µg/mL. Aniline, Meta nitro aniline, Meta anisidine, 2,6-dimethyl aniline, and 3,5-dichloro aniline exhibited intermediate inhibitory activity, while Ortho anisidine and Ortho nitro aniline showed no significant inhibition. Morphological assessments using acridine orange/ethidium bromide (AO/EB) staining revealed diverse cellular responses induced by 2,5-dichloro aniline and 3-chloro aniline treatment. These changes align with well-established apoptotic processes observed in therapeutically treated cell lines. This research contributes valuable insights into the antioxidant and anticancer potential of Diazo Derivatives of 1,3,4-oxadiazole compounds, with 2,5-dichloro aniline and 3-chloro aniline emerging as promising candidates for further exploration in combatting oxidative stress and breast cancer. These findings underscore the importance of antioxidants in cancer prevention and the potential therapeutic applications of these compounds.

Keywords: Diazo Derivatives of 1,3,4-oxadiazole, 2,5-dichloro aniline, 3-chloro aniline, DPPH, MTT assay, MCF-7
Non-Alcoholic Fatty Liver Disease
Authors: Rama Rao Tadikonda , Pratiksha B. , Navyasri C. , Kalita Dwip Jyoti , Alam Shahzad
Published: October 2023

Non-alcoholic fatty liver disease (NAFLD) is characterized by the buildup of fat in the liver, and it is not caused by excessive alcohol consumption. NAFLD is highly prevalent, affecting approximately 30% of the population in developed countries and around 10% in developing nations. As a result, NAFLD has become the most prevalent liver condition worldwide.

The development of NAFLD is closely linked to insulin resistance, making it common among individuals who have central obesity or diabetes. Insulin resistance and excess body fat contribute to a higher influx of lipids into the liver and an increased production of new fats within the liver, known as de novo hepatic lipogenesis. These processes ultimately lead to the accumulation of triglycerides in the liver, a characteristic feature of NAFLD.

NAFLD is closely associated with components of the metabolic syndrome, and individuals with type 2 diabetes have an increased risk of developing cirrhosis and its related complications. While cardiovascular disease and extra hepatic malignancy are the leading causes of death in people with NAFLD, the presence of advanced liver fibrosis is a significant indicator of liver-related outcomes and overall mortality. Non-invasive tests that combine various methods can be used to assess the extent of liver fibrosis. Patients diagnosed with cirrhosis should undergo screenings for hepatocellular carcinoma (a type of liver cancer) and esophageal varices. Currently, there are no approved therapies for NAFLD; however, there are several drugs in advanced stages of development that show promise for future treatment options.

Keywords: Non-alcoholic fatty liver disease, Weight management, Bariatric surgery,  Metabolic surgery, Conservative therapy.
Evaluation of Quality of Life in Rheumatological Patients with Post-Tonsillectomy
Authors: Baloğlu Murat
Published: October 2023

Aim: The main aim of the study was to determine whether tonsillectomy improves the quality of life in adults suffering from chronic or recurrent tonsillitis and in rheumatologically treated patients.

Materials and methods: This study was conducted on seropositive or seronegative patients (n=50) who were followed up with various rheumatological diagnoses (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, etc.) at the physical medicine and rehabilitation clinic of SBU Diyarbakir Gazi Yasargil Education Research Hospital and who were diagnosed with acute or chronic tonsillitis and who applied to the ENT clinic. It was done to follow the pre- and post-operative conditions. In these patients who were decided to undergo surgical treatment, HAQ (Health assessment questionnaire) quality of life scale and VAS (Visual Analog Scala) were applied to evaluate the perception of pain before and at the 6th month after the operation.

Results: In this study of 50 adults, mean age was 28.0 years (SD 7.2 years), 38 adults were followed up in the 1st month of diagnosis, while 12 adults were followed up in the 7th month of diagnosis. All patients experienced significant improvements throughout the treatment process. According to the results of the patients' quality of life scale, it was determined that it increased significantly, primarily due to improvements in general and physical areas. 96% (96/100) of participating patients reported benefiting from tonsillectomy. Patients in the postoperative control group had significantly higher quality of life scores than patients in the preoperative case group (p < 0.001).

Conclusion: Adult patients who underwent tonsillectomy due to acute tonsillitis reported improvement in their quality of life 6 months after surgery. Based on this, physical examination of rheumatological patients who have rheumatological diseases and have undergone tonsillectomy and it is likely to improve general health, create a sense of well-being in patients, and improve overall quality of life. The social benefits of tonsillectomy appear to be negligible. The effects are likely to be long-lasting and have a greater impact on younger patients. The presence of chronic rheumatological disease due to tonsillar inflammation and infective symptoms are the main factors affecting the severity of the disease.
Effects of Meningic Extract on Testicular Torsion/Detorsion
Authors: ERDEMCİ Fikri , DEVECİ Engin , Aşır Fırat , TÜRE Zeynep , SEVİNÇ Ayşenur , ÖLMEZ Mehmet , TEKELİOĞLU Yavuz
Published: October 2023

Introduction: Testicular torsion leads to impaired blood supply to the testicles and ischaemia. The incidence is higher especially in newborns and adolescents. As in the treatment of many diseases, various plant combinations are used to prevent the damage caused by testicular torsion-detorsion. In this study, we aimed to investigate the protective effect of meningic (Pistacia terebinthus L.) extract on testicular torsion-detorsion (T/D) injury histopathologically.

Materials and Methods: The 24 animals used in our experiment were randomly divided into 3 groups. Testicular tissues were stained with hematoxylin-eosin and PAS stains to evaluate histological changes. Modified Johnsen scoring was then performed.

Results: In the sham group sections, seminiferous tubules were regular and germinal epithelium at various stages of spermatogenesis was seen in 4-5 rows on the basal lamina. In PAS stained sections of the sham group, the basement membrane was regular. In the sections of T/D group, destruction of seminiferous tubules, dilatation and congestion were observed in the vessels in the interstitial area. Thickening of the basal laminae of the seminiferous tubules was also detected in the sections of the T/D group stained with PAS. In the sections of meningic + T/D group, a partial recovery was observed in the seminiferous tubules. The basal lamina thickness in PAS-stained sections of meningic + T/D group was found to be close to normal. According to the results of modified Johnsen score analysis, there was a significant difference between the groups (p<0.05).

Conclusion: In our study, it was concluded that meningih extract partially protects the testis and its functions.

Keywords: Testicular injury, torsion, detorsion, meningic extract
EGFR expression in COVID19 placentas
Authors: LİMANDAL Çisem , AKKUŞ Murat , DEVECİ Engin , Aşır Fırat , FINDIKLI Necati , KONK AKINCI Dilara , ÖZDEMİR BAŞARAN Süreyya , KAPLAN Özge , PEKER Nurullah
Published: October 2023

Introduction: Coronavirus disease 2019 (COVID-19) pandemic is a global health problem that has claimed many lives worldwide. The disease is affecting almost all populations, but it poses a particular risk for groups such as the elderly and those with chronic diseases. Although the number of studies on clinical situations involving pregnant women and their infants infected with COVID-19 is increasing, the factors supporting the negative association between COVID-19 and pregnancy remain unclear. In this study, we aimed to examine the placental histopathologic structure using EGFR (Epidermal Growth Factor) antibody in placentas of COVID-19 pregnant patients.

Materials and methods: In our study, placentas of a total of 40 pregnant women (regardless of age), including 20 pregnant women with C0VID-19 and 20 normotensive pregnant women, were used, and placentas were compared histopathologically and immunohistochemically.

Results: In the hematoxylin and eosin stained sections of the control group placentas, tissue integrity was preserved and cellular structures were normal. In the placentas of Covid -19 group patients, it was observed that degenerations increased and cellular deformations developed. In sections of control group placentas, EGFR expression was negative in decidual cells and in areas with syncytial nodes. EGFR expression was positive in cytotrophoblast cells.  In placenta sections of Covid-19 patients, EGFR expression was positive in vascular endothelium and Hofbauer cells.

Conclusion: In our study, it was observed that EGFR expression, an important biomarker in tissue regeneration, was inhibited. We also concluded that Covid-19 caused degeneration and inflammation in placental tissue.
A Comprehensive review of Nigella sativa (kalonji) from the Unani perspective
Authors: Alam Mahboob , Bhat Shabir Ahmad , Rather Shameem Ahmad , Hakeem Naseer Ahmad , Khalique Abdul , Mobin Sana , Azmi Fauzia , Mariyam Zamal
Published: October 2023

The remarkable therapeutic properties of Nigella sativa, often known as black seed or kalonji are well recognized. The use of N. sativa seeds and its oil has a long history in various traditional food and medical systems. As stated by the holy prophet of Islam (PBUH), Shoneez is important since it can cure all diseases with the exception of death. It is widely used in several conventional medical systems, including Unani Tibb, Chinese medicine, Ayurveda, and Siddha.

The goal of the current review is to provide a thorough overview of the literature on scientific studies of the pharmacognostical properties, chemical makeup, and pharmacological activity of the seeds of this plant.

The data was collected from various reputed data bases like PubMed, Science direct, Web of Saciences, Google Scholar and Research Gate. The traditional and Unani literature was also searched from the classical books of Greco-Arab medicine in addition to other digital sources.

According to traditional Unani literature, N. sativa exhibits a variety of pharmacological properties, including those that are carminative, anti-inflammatory, analgesic, diuretic, emmenagogue, galactagogue, and expectorant. Numerous phytochemical, pharmaceutical, and clinical studies have been conducted on N. sativa, revealing its potential anti-diabetic, anti-cancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, bronchodilator, renal protective, gastro-protective, antioxidant, and other properties. N. sativa is among the top-ranked evidence-based herbal medications because of its remarkable healing ability. The main bioactive component of the essential oil, thymoquinone, is responsible for the majority of its medicinal capabilities.

Nigella sativa is a potent herb which exhibits wide range of pharmaceutical properties, most of which have been confirmed via preclinical and clinical studies. This review may thus be useful for the research community in particular and common people in general to avail the benefits of N. sativa.

Keywords: Anti-cancer, Kalonji, Habat-ul-Sauda, Shoneez, Thymoquinone, Nigella sativa, Unani
The Utilization of Secang Wood (Caesalpinia sappan L.) Extract Nanoemulsion as Natural Pigment in Lip Cream Preparations
Authors: Agustin Eriska , Pratiwi Aknes
Published: October 2023

Lip cream is a semi-solid lipstick preparation. One of the important ingredients in lipcream preparations is a variety of colorants. Secang wood contains the active compound brazilin which gives it a yellow to purple color which can be used as a natural dye. The conventional lip cream preparations from extracts have low homogeneity and unstable, so it is necessary to increase the stability of the preparation by making a nanoemulsion of secang wood extract which is incorporated into the lip cream preparation. The preparation of 10% secang wood extract nanoemulsion preparation using Tween 80, Virgin Coconut Oil (VCO), and PEG 400 with particle size reduction using a bath sonicator. The concentration of the nanoemulsion preparation was 1% (F3) and 3% (F4) incorporated into the lip cream base and conventional lip cream preparations with the same concentration (F1 and F2). The test results for the size of the 10% secang wood extract nanoemulsion globules were 127.54 ± 0.45 nm (PI: 0.3 ± 0.013). The test results for the F3 and F4 nanoemulsion lipcream preparations had a pink to purple color, pH 6-6.4, spreadability of 5.9-6.8 cm, adhesion of 5.5-6 seconds, the preparation was homogeneous and non-irritating, compared with conventional lip cream preparations F1 and F2 are not homogeneous, the color of the lip cream is paler, and the irritating properties are very mild in both formulas. The conclusion of this research is that secang wood extract can be formulated into a nanoemulsion preparation and incorporated into a lip cream preparation.

Keywords: Brazilin, Color, Dye, Sonicator Bath
Overview of Analytical Methods for the Determination of H2 Receptor Blockers: A Review
Authors: Adhikari Rudra Prasad , Rahman Samima Nasrin , Lamichhane Suman , Bora Aditya
Published: October 2023

Overview of various analytical methods for estimating anti-histaminic (H2 Receptor blockers) drugs, particularly for determining their concentration percentage (assay) by analytical methods developed on analytical instruments i.e., UV visible Spectrophotometer, High-Performance Liquid Chromatography, and Hyphenated techniques. The review includes a literature survey of H2 receptor blocker drugs namely cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid, Pepcid AC), and nizatidine (Axid). The examined literature survey addressed chromatographic (HPLC) and UV visible spectrophotometric methods with LC-MS/MS methods used in pure forms, pharmaceutical formulations, human plasma, and other biological fluids for their estimation. In the case of validation parameters, mostly Linearity, Recovery study, LOD, and LOQ were considered and mentioned. This review helps researchers to get detailed information regarding various analytical methods of development and validation for H2 receptor antagonists.

Keywords: H2 Receptor blockers, HPLC, Analytical methods, ranitidine, famotidine, nizatidine.
Formulation and Evaluation of Buccal Patches of Diclofenac Sodium as a Model Drug
Authors: Das Debjani , Sur Pallabi , Das Sudipta
Published: October 2023

The present study was concerned with the formulation and evaluation of buccal patches of Diclofenac Sodium. Here, Diclofenac sodium is used as a model drug. Buccal patches of Diclofenac Sodium were preparedby solvent casting method using PEG 400, Glutaraldehyde, Glycerin, HPMC, Gelatin and required quantity of distilled water. Weight variation, thickness, drug content and release studies were assessed.

Keywords: Buccal patch, Diclofenac sodium, oral mucosa, HPMC, PEG-400, Glutaraldehyde.
Therapeutic Drug Monitoring: A Review
Authors: Ranjan Gyan , Jamal Faiqua , Das Subhankar , Gupta Vaibhav
Published: October 2023

Therapeutic drug monitoring (TDM) is well known for adjusting a patient’s medication dose such that the level of drug in their blood remains within a therapeutic range. TDM requires the concentration of a medication to be measured in a variety of physiological fluids.The method by which the medicine is manufactured also has an impact, because certain synthesised pharmaceuticals behave differently in the body than their licenced counterparts. TDM is one of the numerous areas where pharmacoeconomics is now being used. This is happening as both physicians and the general public grow increasingly worried about rising health-care expenses and the preparedness that has been identified as a consequence of using TDM. TDM helps in minimising risk while taking drugs like digoxin, aminoglycosides and various other drugs with narrow therapeutic index. TDM helps in identifying safer drug and dose of a drug by analysing the effects of the drug. TDM is used to ensure that the dosage of medication that you are taking is safe and effective. TDM is the clinical practice that monitors a drug’s or its metabolite’s concentration to guide personalized dosing with the goal of achieving a concentration target that is related to a desired treatment outcome.
Keywords: Therapeutic drug monitoring, vancomycin, aminoglycosides, digitalis, adverse effects.
Investigation of the Protective Effect of Terebinth (Pistacia terebinthus L.) against Ovarian Ischemia-Reperfusion Damage in Rat
Authors: Şengül Gülsüm Pektanç , Deveci Engin , Şengül Seydi Ahmet , Tekelioğlu Yavuz
Published: October 2023

The aim of this study is to investigate the therapeutic and protective effects of Pistacia terebinthus L. (terebinth) oil treatment on experimental ovarian ischemia and reperfusion injury in rats. In the study, 32 Sprague-Dawley female rats; They were divided into 4 groups: control, ischemia, ischemia/reperfusion (I/R), ischemia/reperfusion + terebinth oil (I/R + terebinth oil), 8 in each group. Terebinth oil was applied via oral gavage at a daily dose of 2 ml/kg for 4 weeks. In histopathological examination of ovarian sections, the control group showed a regular histological appearance. In the ischemia and I/R groups, degenerations in the epithelium, inflammatory cell infiltration in the lamina propria region, and bleeding due to thrombosis in the enlarged vessels were observed. It was determined that terebinth oil protected the epithelial tissue after ovarian I/R injury, reduced inflammation in the connective tissue, and brought the artery-vein contours to a regular appearance. In the ovarian sections where immunohistochemistry analysis was performed, it was observed that radixin protein expression showed a positive reaction in the granulosa cells and a negative reaction in the stromal areas in the terebinth oil applied group compared to the I/R group. As a result, it was revealed that terebinth oil has a healing and protective effect in the treatment of ovarian ischemia/reperfusion injury.

Keywords: Terebinth (Pistacia terebinthus L), Ovary, Ischemia, Reperfusion
Improvement of the cooling control during electrofusion welding of polyethylene pipes at low temperatures
Authors: Starostin N. P. , Ammosova O. A.
Published: October 2023

A method has been developed for determining the heater power at the cooling stage when welding polyethylene pipes for gas pipelines at low ambient temperatures (below those recommended by regulatory documents). Efficiency of the method is verified by studies of materials crystallization kinetics in the heataffected zones of welded joints
Study of the surface energy characteristics of glass and carbon fiber by the Washburn method
Authors: Salakhova R. K. , Panarin A. V.
Published: October 2023

The Washburne adsorption method (capillary rise method), as an alternative to the standard single fiber method, is proposed to investigate the surface energy characteristics of glass and carbon fibers using a K- 100 processor tensiometer. The paper considers sample preparation of fibrous materials measured by the Washburn method: filling a Teflon tube with glass and carbon fibers, packing density of the resulting capillary, and determination of the capillarity constant. The results of measurements of the wettability of fibers in test liquids (water, hexane) and in the solution epoxy binder UP-2227N are presented. The influence of appretting on the surface energy characteristics of glass fiber and carbon fiber was studied, a comparative analysis of the obtained values (wetting angle, SEP, adhesion) was carried out before and after the removal of lubricants.
Development of technology for obtaining functional coatings from Kh15Yu5 steel powders
Authors: Bobkova T. I. , Vasiliev A. F. , Gerashchenkov D. A. , Goshkoderya M. E. , Samodelkin E. A. , Farmakovsky B. V.
Published: October 2023

The paper presents the results of research on the development of technology for the application of functional coatings with high values of adhesion strength, microhardness and wear resistance using the method of supersonic cold gas dynamic spraying. Oxidized powder from X15Yu5 steel was used as a starting material for obtaining such coatings.
Analysis of basalt-like slag of plasma waste processing: The influence of morphological composition of waste
Authors: Artemov A. V. , Pereslavtsev A. V. , Voshchinin S. A. , Tresvyatsky S. S. , Korobtsev S. V.
Published: October 2023

The analysis of basalt-like slag obtained by pyrolysis of waste in a high-temperature plasma converter using various physicochemical methods has been carried out, and the possibility of obtaining basalt fibers from slag has been shown. The effect of the morphological composition of waste on the yield of basaltlike slag has been studied. With the use of statistical methods, a mathematical model was obtained that relates the yield of basalt-like slag to the morphological composition of the waste. A promising direction for the use of basalt fibers is their use in the composition of basalt and basalt-carbon composites to create strength shells.
Acoustic emission in hydrostatic strength tests of spheroplastics
Authors: Lebedev V. L. , Kosulnikov V. Yu. , Sery P. V. , Troshkin S. N.
Published: October 2023

Registration of acoustic emission in the process of spheroplastics destruction in a high-pressure hydrostatic chamber is realized. Hardware design does not require specialized equipment and is based on available components. Time synchronization on pressure and acoustic emission graphs ensures pressure fixation of pressures at which the formation of cracks in the spheroplastic sample begins. It is shown that accumulation of destructions begins with pressure, smaller, than pressure fixed as short-term hydrostatic durability.
Comparison of the aggressiveness of hydrogen sulfide media to steel in the vapor and water phases
Authors: Vagapov R. K. , Mikhalkina O. G. , Lopatkin V. А. , Ibatullin K. A. , Strelnikova K. O.
Published: October 2023

Corrosion resistance in hydrogen sulfide-containing environments of the main structural steels used in infrastructure facilities of gas fields has been studied. Gas objects are distinguished by the fact that most of the internal space of equipment and pipelines is in contact with the vapor phase, the internal corrosion of which under hydrogen sulfide conditions has been little studied. The corrosion rates and the composition of the formed corrosion products, which differ depending on the type of medium (water or steam), are determined. The phase composition (crystalline or X-ray amorphous) of the resulting products affects their protective ability and differs in the vapor and aqueous phases. It has been established that under gaseous conditions of moisture condensation, local pitting lesions are formed under fragile corrosion products. The thickness of the iron sulfide film in the vapor phase turned out to be lower than in the aqueous medium. It was revealed that dangerous corrosion consequences (in the form of blisters and cracking) appear on the studied samples of carbon and low-alloy steels, which are characteristic of the process of hydrogenation under conditions of hydrogen sulfide corrosion.
Microstructural aspects of fatigue strength of welded joints of medium carbon steels produced by rotary friction welding
Authors: Isaeva A. V. , Priymak E. Yu. , Atamashkin A. S. , Semka Ya. S.
Published: October 2023

The paper studies the resistance to fatigue failure of welded joints of steels 32Mn2-40CrNi2Mo, intended for the production of drill pipes for geological exploration. The connection of pipe billets for the purpose of manufacturing experimental samples was carried out by means of rotational friction welding at various process parameters. The assessment of resistance to fatigue loads was carried out on solid cylindrical samples with a welded joint under conditions of bending with rotation, which made it possible to identify the weakest zone in which the initiation and development of a fatigue crack occurred. The microstructure was studied using optical and electron scanning microscopy using the electron backscatter diffraction (EBSD) method. In the course of research, it was found that the greatest resistance to fatigue loads is provided due to the intensive development of strain hardening processes in the thermomechanical affected zone of welded joints, which depend on the parameters of rotary friction welding.
Gradients of structure, phase composition and dislocation substructure of the rail heads made of hypereutectoid steel after operation
Authors: Gromov V. E. , Porfiriev M. A. , Ivanov Yu. F. , Kryukov R. E. , Shlyarov V. V.
Published: October 2023

The analysis of gradients of structure-phase states and dislocation substructure at a depth of up to 10 mm along the central axis of the head of DT400IK rails after 234.7 million tons passed on the Transbaikal railroad has been carried out using transmission electron microscopy methods. The formation of bending contours of extinction, indicating the elastically stressed state of the material, is revealed. Sources of curvaturetorsion of the crystal lattice are indicated: intra- and interphase boundaries. The mechanisms of destruction of lamellar pearlite (cutting by moving dislocations) and dissolution with displacement of carbon atoms to defects are considered.
I solution of the heat conduction problem for computational modeling of the hydrogen content reduction in large-size forgings during antiflocken heat processing
Authors: Tsukanov V. V. , Smirnova D. L. , Karkhin V. A. , Khomich P. N. , Efimov S. V.
Published: October 2023

The paper investigates problems of flocken formation in large-sized billets during heat treatment increasing hydrogen degassing. The solution of thermal conductivity problem is given, the estimation of thermal cycles at preliminary heat treatment for the subsequent solution of hydrogen diffusion problem is carried out on the example of medium-alloyed steels of 5KhNM and 20Kh3NMFA grades.
Effect of tungsten on structure of chromium-based heat-resistant alloys
Authors: Butrim V. N. , Adaskin A. M. , Kashirtsev V. V. , Trushnikovа A. S.
Published: October 2023

The effect of tungsten on the structure and properties of Cr–32Ni–W alloys was studied. Characteristic tungsten concentrations were separated: up to 3%, 3–10%, and more than 10%, which determine the structure of the alloys. The mechanical properties of the alloys are determined. The area of rational application of the alloy Cr–32Ni–W is shown.
Forming linguistic-cultural competencies in Kazakhstani students learning Russian as a non-native language
Authors: Arynbayeva Rimma A. , Makhanova Zhanna K. , Dmitryuk Natalya V.
Published: October 2023

The formation of linguistic-cultural competence in the process of teaching Russian as a non-native language is becoming a priority in modern linguodidactics, in particular in the educational space of Kazakhstan. The relevance of the study is in the need to form and develop a fully educated secondary linguistic personality in the multilingual environment of modern society. This requires applying anthropocentric principle in teaching Russian as a linguistic-cultural phenomenon. The aim of the study is to form students' linguistic-cultural competence in precepting the features of the Russian picture of the world, traditional values, and mentality of the Russian ethnic group. The material of the study includes associative dictionaries of the Russian and Kazakh languages, the results of associative experiments with schoolchildren, scientific sources on psycholinguistics and cultural linguistics, Kazakh manuals and textbooks on the Russian language (in schools with Russian/Kazakh language of teaching). In the work comparative and associative experiments, pilot survey were used, as well as the methods of structuring (associative semantic gestalt according to the method of Yu.N. Karaulov), linguistic and cultural commentary, modeling situational exercises and analysis of communicative-speech acts. The results of the study illustrate the specificity of students' ethnolinguistic awareness at the associative level. The relevance of linguistic and cultural commentary for widening students' ethno-mental outlook and organising adequate intercultural dialogues is grounded. The effectiveness of associative experiments materials as a means of forming linguistic-cultural competence of students is shown.
Foreign humanitarian students’ perception of a precedent name in the Russian discourse
Authors: Sarycheva Maria R. , Derybina Svetlana A.
Published: October 2023

The high recognizability of the precedent names among the native speakers of a particular linguistic culture has led to the relevance of studying these linguistic units in the aspect of foreign language teaching, where considerable attention is paid to the formation of linguistic-cultural competence. The aim of the work is to study the peculiarities of precedent name perception in the Russian language discourse by humanitarian foreign students. The materials of the research included adapted and original texts, Internet memes with precedent names. The subject of analysis was precedent names from literary works and movies. The nature of the material under study necessitated the use of the continuous sampling method. Twenty-seven precedent names from fiction and journalistic texts, from Internet memes were used. Further processing of the obtained results was carried out with the help of descriptive, contextual and semantic analyses. A total of seven tasks were offered to recognize precedent names in fiction, journalistic and educational texts and to correlate the precedent names with their characteristics and sources. It was proved that the indicator of the attractiveness of precedent names in Russian language teaching is the interest of foreigners in characters that are highly recognizable by native speakers, the reference to sources significant for native speakers, and the possibility to correlate them with the precedents from their native linguistic culture. The authors describe the specifics of selecting significant precedents for native speakers of a particular linguistic culture and suggest compiling a linguistic-cultural commentary on the language units studied, considering the realities of the country of the language under study. Moreover, the high interest of foreign students to the memes containing precedents shows the research perspective in terms of defining the principles of selecting the precedents and developing appropriate methodological recommendations.
Comprehensive diagnostics of the level of Russian language proficiency in a multiethnic Russian school
Authors: Khamraeva Elizaveta A. , Kytina Natalia I. , Bolmazova Elena V.
Published: October 2023

The most important tool for the adaptation and integration of foreign-speaking children into the Russian educational space is the Russian language. In modern Russian schools, the most pressing issue is the assessment of the level of proficiency in Russian by foreign children, since in the situation of formed migration there is no common institutional complex for the diagnosis of these children's language and speech skills. It is necessary first of all to make diagnostic measurements of the ability of school children from migrant families to master school subjects in Russian. The lack of methodological tools of this kind complicates the process of adaptation of foreign language students to the educational space of the Russian school. This circumstance conditioned the tools for developing and implementing complex diagnostics aimed at determining the language skills and the level of speech competence not only of foreign-speaking children, but also of all students in educational institutions of the Domodedovo city district. The aim of the study was to determine the general didactic and methodological requirements for a foreign-speaking student in a Russian school, and to create an effective tool for defining the linguistic and socio-cultural competencies of this category of students. The research development of the diagnostic procedures carried out and their results aimed at determining the levels of Russian language proficiency among students of 5-9 grades in the polyethnic composition of the Domodedovo city district are presented. Within the framework of the study, methods of pedagogical observation, statistical method, method of diagnostic testing and expert evaluation, method of quantitative processing of the obtained data were applied. In the diagnosis 1248 students of Domodedovo city district schools took part. The testing was carried out in electronic format, which made it possible to obtain and process the results in the shortest possible time. The methodological basis for the research and development of testing materials was the manual by Elizaveta A. Khamraeva “Linguodidactic diagnostics” (the series “Russian school”), which includes tests for children aged 6-14 years, compiled on the basis of the meta-subject approach. The results of this study can serve as a content base for individual educational trajectories, based on the principles of differentiated learning, which will contribute to the successful learning of academic disciplines in accordance with the requirements of the Federal State Educational Standard in a modern multicultural school.
THE QUALITY OF THE CHAIN (SANAD) OF HADITH CONCERNING THE LEGAL GUARDIAN (WALI) OF THE NIKAH
Authors: Sa’dan Saifuddin , Riana Ardelia Vidya
Published: October 2023

The Wali (women's guardian of marriage) as a condition for a valid nikah (marriage) is not particularly discussed in the Qur'an. 1 It is explained more in the hadith of the Prophet, such as "unlawful marriage without a guardian" (Narrated by Arba'ah) or statements about "a widow has more rights over herself than her guardian while a bikr (young woman) needs to be asked for permission" (Narrated by Muslim).
SEXUAL HARASSMENT BY CHILDREN IN THE ACEH PROVINCE: A CASE STUDY ON THE JINAYAT BYLAW
Authors: Nur Muhammad , Harun Harun , Bakry Nurdin
Published: October 2023

The Aceh province is a special autonomous region with the authority to carry out Islamic Sharia. Article 125 of Law Number 11 of 2006 concerning the Aceh Government emphasizes that the Sharia implemented in Aceh includes aqidah (creed), syar'iyah, and akhlaq (disposition). However, Sharia implementation in Aceh has not fully affected the social conditions of its people, especially since child crimes, such as sexual harassment, still happen. Acehnese people are religious and view the relationship between men and women as sacred and can only happen through marriage. Hence, sexual harassment is against the Acehnese people's Islamic life views and beliefs. This study aims to explain the factors that cause children to commit sexual harassment in Aceh Province. This study is empirical legal research that collects primary and secondary data. Data analysis employed a descriptive-analytical approach. The study shows that children commit sexual harassment in Aceh due to two factors, namely internal factors, i.e., children's lack of religious knowledge and sexual desire, and external factors, i.e., lack of parental supervision as well as influence from communication and social media.

Abstrak: Propinsi Aceh sebagai Daerah Otonomi khusus mempunyai kewenangan untuk menjalankan syari’at Islam, dalam Undang-Undang Nomor 11 Tahun 2006 tentang pemerintah Aceh, pada Pasal 125 ditegaskan bahwa Syari’at Islam yang dilaksanakan di Aceh meliputi aqidah, syar’iyah dan akhlak. Namun kebijakan penerapan syari’at Islam di Provinsi Aceh belum sepenuhnya berpengaruh terhadap kondisi social masyarakatnya, terutama masih terjadi tindak criminal yang dilakukan oleh anak yaitu Pelecehan seksual. Pada dasarnya masyarakat Aceh adalah masyarakat yang religius, dan memandang hubungan antara laki-laki dan perempuan sebagai hubungan yang sakral. Hubungan tersebut hanya dapat dilakukan melalui lembaga perkawinan. Sehingga tindak pidana pelecehan seksual sangat bertentangan dengan pandangan hidup dan keyakinan masyarakat Aceh yang Islami. Penelitian ini bertujuan untuk menjelaskan bagaimanakah faktor penyebab anak melakukan pelecehan seksual di Propinsi Aceh. Penelitian ini menggunakan penelitian hukum empiris, pengumpulan data dilakukan melalui data primer dan data sekunder. Analisis data menggunakan pendekatan deskriptif-analitik. Berdasarkan hasil penelitian dapat diketahui bahwa   anak melakukan pelecehan seksual di Propinsi Aceh disebabkan oleh dua factor yaitu factor internal, berupa; anak kekurangan ilmu pengetahuan agama dan dorongan nafsu birahi. Adapun faktor eksternal, anak melakukan pelecehan seksual karena kurang mendapatkan pengawasan orang tua dan pengaruh media komunikasi dan media social.

Kata Kunci: Pelecehan Seksual, Anak Sebagai Pelaku, Hukum Jinayat
LEGAL ANALYSIS OF UNREGISTERED MARRIAGE VIEWED FROM ULAMA’S PERSPECTIVE IN ACEH PROVINCE
Authors: Jauhari Iman , Yahya Azhari , Darmawan Darmawan , Dahlan Dahlan , Nasir Muhammad
Published: October 2023

The purpose of this study is to scrutinize the legal analysis of unregistered marriage, to identify the factors that cause unregistered marriages, and to analyze the views of ulama about unregistered marriage in Aceh. The method used in this research is an empirical juridical method with a qualitative approach. This research was conducted in Aceh and data collection was carried out by means of field research supported by library research. The results show that marriage registration has been regulated in the Marriage Law and in the Islamic Compilation Law as well as a set of implementing regulations in the field of marriage registration. The factors that cause unregistered marriage in Aceh among others are economic factors, illegal pregnancy, lack of understanding and awareness about marriage law, prolonged affairs, not having a guardian, avoiding administrative procedures, and avoiding adultery. The Acehnese Ulama say that generally, they accept marriage registration because it has benefits for the family such as registration of children's birth certificates, and family cards as administrative requirements in other legal acts. However, they refuse to register the marriage if it is related to other provisions such as the age of marriage, polygamy permits, and disputes involving the family.
LEGISLATIVE ELECTIONS: AN OVERVIEW OF CLOSED PROPORTIONAL SYSTEM
Authors: Mutawalli Muhammad , Maskun  , Ayub Zainal Amin , Tajuddin Muhammad Saleh , Wahab Harlida Abdul
Published: October 2023

This study aims to analyze the constitutionality of legislative general elections with a review of the closed proportional system in the 1945 Constitution. The legislative election system is an important tool for maintaining democratic principles and fair representation in a country. The constitutionality of the closed proportional system has been the subject of ongoing debate. This study uses a qualitative approach with normative juridical methods to analyze the constitutionality of general legislative elections that use a closed proportional system. This approach involved collecting data from legal documents, literature studies, and court decisions that were relevant to this topic. The results of the study showed that the application of a closed proportional system in legislative general elections has several constitutional implications, such as the limitation of political access for individuals outside of political parties, which can be considered as a violation of the individual's constitutional right to participate in the political process. This research also showed that a closed proportional system can provide greater political stability and strengthen the role of political parties in the political system. This study also analyzed the implications of implementing an open proportional system in legislative general elections.

Abstrak: Penelitian ini bertujuan untuk mengkaji konstitusionalitas pemilihan umum legislatif dengan tinjauan terhadap sistem proporsional tertutup dalam UUD 1945. Sistem pemilihan umum legislatif adalah aspek penting dalam menjaga prinsip demokrasi dan keterwakilan yang adil dalam sebuah negara. Sistem proporsional tertutup telah menjadi subjek perdebatan yang berkelanjutan mengenai konstitusionalitasnya dalam konteks UUD 1945. Penelitian ini menggunakan pendekatan kualitatif dengan metode yuridis normatif untuk menganalisis konstitusionalitas pemilihan umum legislatif dengan menggunakan sistem proporsional tertutup. Pendekatan ini melibatkan pengumpulan data dari dokumen hukum, studi literatur, dan putusan pengadilan yang relevan dengan topik ini. Hasil penelitian menunjukkan bahwa penerapan sistem proporsional tertutup dalam pemilihan umum legislatif memiliki beberapa implikasi konstitusional. Pertama, sistem ini dapat membatasi akses politik bagi individu di luar partai politik, yang dapat dianggap sebagai pelanggaran terhadap hak konstitusional individu untuk berpartisipasi dalam proses politik. Penelitian ini juga menganalisis implikasi penerapan sistem proporsional terbuka dalam pemilihan umum legislatif. Penelitian ini juga menunjukkan bahwa sistem proporsional tertutup dapat memberikan stabilitas politik yang lebih besar dan memperkuat peran partai politik dalam sistem politik.

Kata Kunci: Konstitusionalitas, Pemilihan Umum Legislatif, Sistem Proporsional Tertutup, UUD 1945, Kebebasan Politik
ROBOTICS AND AUTOMATION: THEIR IMPACT ON THE SOCIAL SECURITY OF CRITICAL INFRASTRUCTURE WORKERS
Authors: Kaylo Ivan , Lubinets Dmytro , Kryvenko Dmytro , Mykolaiets Dmytro , Platonova Hanna
Published: October 2023

Automated robotics is significantly changing the way we live and work. The use of automation technologies is becoming more and more common either in manufacturing or in healthcare. This technology improves workplace safety significantly since robots can perform dangerous or repetitive tasks. It also reduces the risk of injury to workers. The topic of robotics and automation is relevant in Ukraine, given the war and the frequent shelling of critical infrastructure facilities. Currently, robotics and automation have great potential to improve the social security of critical infrastructure workers in conditions of war and frequent shelling of objects. They can ensure safety, productivity, and operational stability and improve emergency response capabilities. The purpose of the article is to study the issue of robotics and automation in the modern world and their impact on the social security of critical infrastructure workers in particular.

Abstrak: Robotika otomatis secara signifikan mengubah cara kita hidup dan bekerja. Penggunaan teknologi otomasi menjadi semakin umum baik di bidang manufaktur maupun di bidang kesehatan. Teknologi ini meningkatkan keamanan tempat kerja secara signifikan karena robot dapat melakukan tugas berbahaya atau berulang. Ini juga mengurangi risiko cedera pada pekerja. Topik robotika dan otomasi relevan di Ukraina, mengingat perang dan seringnya penembakan fasilitas infrastruktur penting. Saat ini, robotika dan otomasi memiliki potensi besar untuk meningkatkan jaminan sosial pekerja infrastruktur kritis dalam kondisi perang dan seringnya penembakan objek. Mereka dapat memastikan keselamatan, produktivitas, dan stabilitas operasional serta meningkatkan kemampuan tanggap darurat. Tujuan artikel ini adalah untuk mempelajari masalah robotika dan otomasi di dunia modern dan dampaknya terhadap jaminan sosial pekerja infrastruktur kritis pada khususnya.

Kata Kunci: Otomatisasi, Infrastruktur Kritis, Robotika, Jaminan Sosial Pekerja, Perlindungan Pekerja
PSEUDO-ENVIRONMENTAL VALUES VERSUS ETHICAL SPIRITUALITY: A STUDY ON INDONESIAN GREEN SUKUK
Authors: Bin-Armia Muhammad Syauqi
Published: October 2023

This paper investigates and inspects the application of green sukuk as an Islamic environmentally accepted bond and its impacts on the global market. Law No.19 of 2008 on Shariah Government Securities, governs the exercise of green sukuk that accepts two basic norms, Shariah compliance and ecosystem friendly. Philosophically speaking, environmental preservations are embedded in Shariah as a core principle. Shariah persuaded unharmed human beings as well as other creatures. The amalgamation between the sharia principle and environmental values out to be sufficient to manifest the objective. The research aims to examine the worthiness of new emerging sukuk while carrying the same basic principle on moral, ethical and environmental embeddedness within the sukuk itself. The research methodology conducted in this research will implement mixed-methods through qualitative and quantitative approaches. The research indicates that green sukuk issuance has no contribution toward global sukuk performances signaled by selected sukuk indices on the issuance date. In addition, there are no sufficient assessment mechanism indicators to ensure the application of environmental distinctive values and shariah compliance implimentations.

Abstrak: Tulisan ini menyelidiki penerapan green sukuk sebagai obligasi Islam yang ramah lingkungan dan dampaknya terhadap pasar global. Undang-Undang Nomor 19 Tahun 2008 tentang Surat Berharga Syariah Negara (SBSN) mengatur pelaksanaan green sukuk yang menganut dua norma dasar, yaitu kepatuhan syariah dan ramah ekosistem. Secara filosofis, pelestarian lingkungan hidup tertanam dalam syariah sebagai prinsip inti. Syariah mengatur prinsip untuk tidak merugikan manusia dan juga makhluk lainnya. Penggabungan antara prinsip syariah dan nilai-nilai lingkungan sudah cukup untuk mewujudkan tujuan tersebut. Penelitian ini bertujuan untuk menguji kelayakan jenis sukuk yang baru ini dengan tetap mengusung prinsip dasar yang sama mengenai keterikatan moral, etika, dan lingkungan dalam sukuk itu sendiri. Metodologi penelitian yang dilakukan dalam penelitian ini akan menerapkan mix-methods melalui pendekatan kualitatif dan kuantitatif. Hasil penelitian menunjukkan penerbitan green sukuk tidak memberikan kontribusi terhadap kinerja sukuk global yang ditunjukkan oleh indeks sukuk pada tanggal penerbitan. Selain itu, tidak ada indikator mekanisme penilaian yang memadai untuk memastikan penerapan nilai-nilai keistimewaan lingkungan dan kesuksekan dampak syariah pada sukuk tersebut.

Kata kunci: Sukuk Hijau, Lingkungan, Benturan Nilai, Pasar Modal.