bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison between 2,000 m and 3,000 m time trials to estimate the maximal aerobic speed for collegiate runners
Authors: Du Zonghao , Lu Wei , Lang Diandong
Published: September 2022

Considered to be a lesser resource burden, 2,000 and 3,000 m time trials (TTs) have been recognized as alternatives to accurately estimate the maximal aerobic speed (MAS) derived from laboratory-graded exercise testing (GXT). Previous studies have commonly used ordinary least squares linear regression and the Bland–Altman method to compare the agreement between MAS and TT performance. The agreement analysis aimed to identify the systematic bias between the results of the two methods, rather than to identify similarities. The model II regression technique (ordinary least product regression) is increasingly favored by researchers in the field of physiology. Thus, we aimed to 1) use the ordinary least product (OLP) and bootstrap methods to determine the agreement between the average speed of 2,000 m TT (S2000) and the average speed of 3,000 m TT (S3000) and 2) determine whether S2000 or S3000 can accurately approximate the GXT-derived MAS. It is used as an alternative to estimate the MAS and prescribe training intensity. Thirty-five Beijing Sport University recreational male runners completed an MAS test in laboratory settings, followed by 2,000 and 3,000 m TTs randomly, with a 7-day interval. OLP regression was used to analyze the agreement between the GXT-derived MAS and S2000 and S3000. The bootstrap method was used to calibrate the equations. Differences between the GXT-derived MAS and S2000 and S3000 were compared using a one-way repeated measure analysis of variance (ANOVA) and a post hoc analysis (Bonferroni). The significance level was p < 0.05. The results showed that before calibration, the 95% CI of the OLP regression intercept and slope between the GXT-derived MAS and S2000 and S3000 did not include 0 and 1.00, respectively. These values, after calibration, included 0 and 1.00, respectively. Post hoc analysis revealed that S3000 closely approximated the GXT-derived MAS and underestimated 0.46% (0.06 km h−1 and p > 0.05), and S2000 overestimated 5.49% (0.81 km h−1 and p < 0.05) by the MAS. It concluded that the 3,000 m TT performance approximated the GXT-derived MAS compared to the 2,000 m TT performance. There exist fixed bias and proportional bias between the GXT-derived MAS and TT performance. More attention should be applied to calibration when using the TT performance to estimate the MAS.
Genipin modified lyophilized platelet-rich fibrin scaffold for sustained release of growth factors to promote bone regeneration
Authors: Liu Xiaoyao , Yin Mingjing , Li Ying , Wang Jianqun , Da Junlong , Liu Zhongshuang , Zhang Kai , Liu Lixue , Zhang Wenxuan , Wang Peijun , Jin Han , Zhang Bin
Published: September 2022

Lyophilized platelet-rich fibrin (L-PRF) was shown to further activate resident platelets in platelet-rich fibrin causing a higher amount of growth factors release. However, it still required further experimental studies to resolve the uncontrolled degradation and burst release problem. In this study, the nature crosslinker genipin is introduced to improve the performance of L-PRF scaffold. We used a series of gradient concentration genipin solutions to react with L-PRF. The crosslinking degree, micro morphology, mean pore size, water absorption and mechanical properties of the crosslinked scaffold were evaluated. In order to study the effect of genipin modification on the release kinetics of growth factors from L-PRF, we detected the release of platelet-derived growth factor, vascular endothelial growth factor and transforming growth factor in vitro by ELISA. To investigate the biodegradability of the crosslinked L-PRF in vivo, the scaffolds were transplanted subcutaneously into backs of rats, and the materials were recovered at 1, 2 and 4 weeks after implantation. The biodegradation, inflammatory reaction and biocompatibility of the scaffolds were examined by histological staining. Finally, the genipin crosslinked/uncrosslinked L- Platelet-rich fibrin scaffolds were implanted with freshly prepared SHED cell sheets into rat critical size calvarial defects and the skull samples were recovered to examine the treatment efficacy of genipin crosslinked L-PRF by histologic and radiographic approaches. Results of this study indicated that genipin can be used to modify L-PRF at room temperature at a very low concentration. Genipin-modified L-PRF shows better biomechanical performance, slower biodegradation, good bioavailable and sustained release of growth factors. The 0.01% w/v and 0.1% w/v genipin crosslinked L-PRF have good porous structure and significantly promote cell proliferation and enhance the expression of key genes in osteogenesis in vitro, and work best in promoting bone regeneration in vivo.
The relationship between Chinese preschool principal leadership styles and teacher leadership: Exploring the mediating effect of psychological capital
Authors: Zhang Limin , Wu Tingting , Liu Lijia , Ren Ping , Lin Chaopai
Published: September 2022

Enhancing teacher leadership is not only one of the approaches to improving teaching and learning, but it is also essential to the success of education reform. Based on leader-member exchange theory, 294 preschool teachers in China were surveyed, and a structural equation model was established to explore the relationship between the participating teachers' principal leadership style, teacher leadership and psychological capital. The findings revealed a significant positive correlation between transformational and transactional leadership styles and preschool teacher leadership. The laissez-faire leadership style had no correlation with preschool teacher leadership. The transformational leadership style and transactional leadership style were significantly and positively correlated with psychological capital, while the laissez-faire leadership style was significantly and negatively correlated with psychological capital. The transformational leadership style can positively influence preschool teacher leadership directly and indirectly through psychological capital; and the transactional leadership style can only positively influence preschool teacher leadership indirectly through the mediating role of psychological capital. Preschool teachers' leadership can neither be directly influenced by a laissez-faire leadership style nor be indirectly influenced through the mediating role of psychological capital.
“Expecting the unexpected?” Uncovering role expectation differences in a Dutch hospital
Authors: Wolffgramm Milan , Bücker Joost , Van der Heijden Beatrice
Published: September 2022

The aim of this study was to empirically investigate differences in role expectations, among the stakeholders involved, about the devolved personnel management role of front-line managers (FLMs). In particular, we researched the role expectation differences between FLMs, their middle managers, and Human Resource (HR) practitioners. In total, nineteen semi-structured interviews have been conducted involving eleven FLMs, eight middle managers, and two HR practitioners working at the same Dutch hospital. Most discovered role expectation differences were related to how FLMs should execute their HR tasks (i.e., process ambiguity). FLMs were often uncertain if their role enactment met those of their middle managers and/or HR practitioners, herewith indicating role stress. Our findings underline the importance of paying attention to role expectations’ differences in aligning components of the HRM-performance relationship. Future research could include the role expectations of other important stakeholders, such as: subordinates and top management. The outcomes of this empirical work are translated into four interventions to diminish FLMs’ role stress.
The relationship between parental phubbing and learning burnout of elementary and secondary school students: The mediating roles of parent-child attachment and ego depletion
Authors: He Qingqing , Zhao Bihua , Wei Hua , Huang Feng
Published: September 2022

In this study, we examined the effects of parental phubbing on learning burnout in elementary and secondary school students and its mechanism of action. A questionnaire method was applied to investigate parental phubbing, parent–child attachment, ego depletion, and learning burnout among 2090 elementary and secondary school students in Anhui Province, China. The results are as follows: (1) Parental phubbing was significantly correlated with parent–child attachment, ego depletion, and learning burnout; (2) Parental phubbing has an indirect impact on learning burnout in elementary and secondary school students through three pathways: a separate mediating effect on parent–child attachment, a separate mediating effect on ego depletion, and a chain mediating effect on both. Parental phubbing is a risk factor for Learning Burnout, which can positively affect Learning Burnout in elementary and secondary school students. The findings of the study contribute to revealing the influence mechanism of parental phubbing on learning burnout in elementary and secondary school students.
Moral decision-making during the COVID-19 pandemic: Associations with age, negative affect, and negative memory
Authors: Daley Ryan T. , Cunningham Tony J. , Kensinger Elizabeth A.
Published: September 2022

The COVID-19 pandemic provided the opportunity to determine whether age-related differences in utilitarian moral decision-making during sacrificial moral dilemmas extend to non-sacrificial dilemmas in real-world settings. As affect and emotional memory are associated with moral and prosocial behaviors, we also sought to understand how these were associated with moral behaviors during the 2020 spring phase of the COVID-19 pandemic in the United States. Older age, higher negative affect, and greater reports of reflecting on negative aspects of the pandemic were associated with higher reported purchase of hard-to-find goods, while older age and higher negative affect alone were associated with higher reported purchase of hard-to-find medical supplies. Older age was associated with what appeared at first to be non-utilitarian moral behaviors with regard to the purchasing of these supplies; However, they also reported distributing these goods to family members rather than engaging in hoarding behaviors. These findings suggest that advancing age may be associated with engagement in utilitarian moral decision-making in real-world settings more than the sacrificial moral decision-making literature would suggest.
Impact of multiple performance feedback and regional institutional development on enterprises’ exploratory innovation
Authors: Su Xin , Fu Wenxiu
Published: September 2022

With the increasing uncertainty in the external environment, exploratory innovation has gradually become the key path for enterprises to obtain core competitiveness and achieve sustainable growth. According to the behavioral theory of the firm, performance feedback is an essential driving factor affecting corporate innovation decisions. However, previous studies have ignored the consistency or inconsistency between historical and industry performance feedback, and its impact on exploratory innovation. Based on the data of Chinese companies listed from 2008 to 2019, this paper explores the impact of consistency and inconsistency between historical and industry performance feedback on enterprises’ exploratory innovation. In the cases of consistency, this study finds that the scenario of historical performance shortfall-industry performance shortfall is more likely to promote enterprises’ exploratory innovation than the industry performance surplus-historical performance surplus; in the cases of inconsistency, compared with historical performance surplus-industry performance shortfall, the scenario of historical performance shortfall-industry performance surplus is more likely to promote enterprises’ exploratory innovation. Further research shows that regional institutional development enhances these relationships. This study enriches the driving factors of enterprises’ exploratory innovation from the perspective of multiple performance feedback, which can provide decision-making references for enterprises’ exploratory innovation strategies.
Unhealthy mind in a healthy body: A criticism to eliminativism in psychopathology
Authors: Mancini Francesco , Mancini Alessandra , Castelfranchi Cristiano
Published: September 2022

In this article we criticize the thesis “The diseases we treat are diseases of the brain”. A first criticism is against the eliminativist perspective and in favor of a perspective that is still reductionist but emergentist and functionalist. In a second part, we try to answer the question “under which conditions can we consider this statement legitimate?”. We argue that only those mental disorders whose neural substrate has clearly neuropathological characteristics, i.e., anomalies with respect to the laws of good neural functioning, can be considered “brain diseases.” We propose that it is not sufficient to observe a simple difference between the brains of people with psychopathology, that is, with anomalies with respect to the laws of good psychological functioning, and that of people without psychopathology. Indeed, we believe it is a categorical error to postulate a neuropathology starting from a psychopathology. Finally, we summarize some research that shows how purely psychological interventions can reduce or eliminate the differences between the brains of people with or psychopathology and those of people without.
Psychoeducation, motivational interviewing, cognitive remediation training, and/or social skills training in combination for psychosocial functioning of patients with schizophrenia spectrum disorders: A systematic review and meta-analysis of randomized controlled trials
Authors: Lu Erin Yiqing , Cheng Andy S. K. , Tsang Hector W. H. , Chen Juan , Leung Samuel , Yip Annie , Lin Jessie Jingxia , Lam Zoe Violet , Zhang Wufang , Zhao Miaomiao , Ma Ning
Published: September 2022

Objectives

Psychoeducation, motivational interviewing, cognitive remediation training, and social skills training have been found to be effective interventions for patients with schizophrenia spectrum disorders. However, their efficacy on psychosocial functioning when provided in combination remains unclear, compared with all types of control conditions. It would also be meaningful to explore the differences of efficacy in patients with first-episode psychosis (FEP) and those with longer term of illness.

Methodology

The present review followed the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Full-text English journal articles of randomized controlled trials published in the past decade in the databases of PubMed, CINAHL Complete, Embase, and PsycINFO were searched. Included studies were all randomized controlled trials (RCTs) with participants diagnosed with schizophrenia spectrum disorders. The included studies should test combined interventions with at least two components from: psychoeducation, motivational interviewing, cognitive remediation training, and social skills training and incorporate assessment of psychosocial functioning at least at baseline and post-intervention.

Results

Seven studies were included for systematic review, and six of them were eligible for meta-analysis. Five out of the seven studies reported effects on psychosocial functioning that favored combined interventions over any type of control condition. A significant pooled effect was derived from the six studies, SMD = 1.03, 95% CI [0.06, 2.00], Z = 2.09, p = 0.04, I2 = 96%. However, the pool effect became insignificant when synthesizing five of the studies with non-FEP patients as participants and four of the studies testing relative effects of combined interventions compared with stand-alone interventions/interventions with one less component. None of the included studies adopted motivational interviewing and only one of the studies worked with FEP patients.

Conclusion

Psychoeducation, cognitive remediation training, and social skills training in combination can effectively enhance psychosocial functioning of patients with schizophrenia spectrum disorders. It is warranted to conduct more RCTs to test the effects of different specific combinations of the above interventions on psychosocial functioning, especially in FEP patients.
Association between maternal shift work during pregnancy child overweight and metabolic outcomes in early childhood
Authors: Liao Che-Wei , Wei Chih-Fu , Chen Mei-Huei , Hsieh Wu-Shiun , Lin Ching-Chun , Chen Pau-Chung
Published: September 2022

Background

Previous studies found that maternal shift work during pregnancy was associated with many reproductive hazards, including small for gestational age, preterm birth, stillbirth, and neurodevelopmental impairment. Some studies also showed that these children are more likely to become overweight in early childhood. However, the association with metabolic factors, such as insulin resistance and dyslipidemia, was less studied. Hence, we aimed to understand better the relationship between maternal shift work during pregnancy and the risk of childhood overweight and metabolic outcomes. Confounding factors were also discussed, including diet, exercise, and demographical factors.

Methods

We enrolled pregnant women before delivery in the Taiwan Birth Panel Study (TBPS) II conducted between 2010 and 2012, and followed the children of these participants in 2018. The objective of this study is to investigate the influence of prenatal and postnatal factors on infant and early childhood health. During the follow-up in 2018, we checked children's demographic data, obtained blood specimens, and checked their blood sugar, blood insulin, and lipid profiles. Structured questionnaires were used to evaluate demographic data. Multiple linear and logistic regressions were used to examine the associations between maternal shift work during pregnancy and child overweight, metabolic disorders, such as HOMA-IR, and lipid profiles.

Results

In this study, we included 407 mother-children pairs with different work shifts (350 day workers and 57 shift workers), and a sub-population without underweight children was also created (290 day workers and 47 shift workers). Shift work during pregnancy was associated with a higher Homeostasis Model Assessment-Insulin Resistance index (HOMA-IR) and a higher odds ratio for overweight in children born from mothers doing shift work during pregnancy after adjustment. The findings were attenuated when we investigated the effect of shift work before pregnancy.

Conclusion

Our study suggested that maternal shift work during pregnancy was associated with child overweight and insulin resistance in early childhood.
Digital physiotherapy intervention in children in a low resource setting in Anantapur (India): Study protocol for a randomized controlled trial
Authors: Estebanez-Pérez María-José , Martín-Valero Rocío , Moreno-Morales Noelia , Liñán-González Antonio , Fernández-Navarro Rocío , Pastora-Bernal José-Manuel
Published: September 2022

Introduction

In rural India the scarcity of physiotherapists and inequalities complicate the recovery of traumatized children. This study protocol will explore a digital physiotherapy intervention in children with ankle fracture in a low-resource setting to improve functional independence and quality of life.

Methods and analysis

A randomized clinical trial with a mixed quantitative-qualitative design will be carried out. It is a single-blind study, where the evaluator does not know the nature of the intervention. Sixty subjects will be enrolled and randomly divided into two groups: the experimental group (EG) will receive a 4-week digital physiotherapy intervention through an app in a recycled mobile device after hospital discharge; the control group (CG) will receive the physiotherapy standard care recommended for patients discharged from the hospital. Subjects will receive a baseline (T0-pre) assessment of Functional Independence and Quality of Life. At the end of the 4-week intervention (T1-post) a new assessment of the outcome will be performed adding data on adherence, satisfaction (ad hoc questionnaire and TSQ), and barriers of use. Qualitative outcomes will also be explored. The author's hypothesized that the implementation of a digital physiotherapy intervention is feasible and effective to improve functional independence and quality of life. This study protocol is the first to explore the effect of digital physiotherapy intervention in children's patients in a low resource setting (Anantapur).

Discussion

The successful delivery of the intervention, an optimal adherence records, the absence of significant adverse effects, user satisfaction level and the qualitative analysis of limitations, will demonstrate the effectiveness of these procedure. This study will add more evidence in support the use of digital physiotherapy practice as an effective tool. User particularities, provider's capacity, technological and cultural limitations, and considerations for vulnerable populations will be taken into account.

Clinical trial registration

NCT04946695 (https://clinicaltrials.gov/).
Related Risk Factors of Early Childhood Caries in Zhejiang Province, China During the COVID-19 Pandemic
Authors: Huang Chaoqiang , Zhu Kangqi , Feng Yibing , Lian Luya , Zhu Haihua , Hu Jian
Published: September 2022

Objectives

This work aims to examining the latest early childhood caries situation in children aged 3 and 5 and its related risk factors in Zhejiang Province during the COVID-19 pandemic.

Method

There are 3,537 children and their main caregivers participate in this study. We used chi square test or U-test to analyze whether there were differences in the prevalence of dental caries under different variables. The risk factors on ECC were determined by multivariate logistic analysis.

Results

The ECC rate of children in this study was 57.51%. The mean decayed missing filled teeth (dmft) scores were 3.01. The result of multivariate logistic analysis showed higher ECC prevalence was found in children as age increasing, with lower district economic level, with high frequency of confectionary consumption, having oral medical treatment behavior and bad evaluation of children's oral health by parents.

Conclusion

In general, the prevalence rate of ECC in this study was lower than five years ago, but still higher than those developed countries. And it was associated with age, district economic level, frequency of confectionary consumption, oral medical treatment behavior and evaluation of children's oral health by parents.
Structural and health system determinants of health outcomes in systemic lupus erythematosus: Understanding the mechanisms underlying health disparities
Authors: Leung Jerik , McMorrow Lily , BeLue Rhonda , Baker Elizabeth A.
Published: September 2022

Chronic diseases are increasingly responsible for the burden of health outcomes across the world. However, there is also increasing recognition that patterns of chronic disease outcomes (e.g., mortality, quality of life, etc.) have inequities across race, gender, and socioeconomic groups that cannot be solely attributed to these determinants. There is a need for an organizing framework which centers fundamental causes of health disparities that may better guide future work in centering these mechanisms and moving beyond acknowledgment of health disparities. In this paper, we synthesize several concepts from health disparities literature into a conceptual framework for understanding the interplay of patients' lived experiences, the health care system and structural determinants. Our framework suggests that (1) structural factors influence the health care system, the patient, the health care provider, and the provider-patient relationship through process of subordination and (2) that structurally competent actions are critical to reducing health inequities. The addition of subordination to theoretical frameworks involving health equity and social determinants of health, along with engagement with concepts of structural competency suggest several systems level changes to improve health outcomes.
Spatio-temporal categorization for first-person-view videos using a convolutional variational autoencoder and Gaussian processes
Authors: Nagano Masatoshi , Nakamura Tomoaki , Nagai Takayuki , Mochihashi Daichi , Kobayashi Ichiro
Published: September 2022

In this study, HcVGH, a method that learns spatio-temporal categories by segmenting first-person-view (FPV) videos captured by mobile robots, is proposed. Humans perceive continuous high-dimensional information by dividing and categorizing it into significant segments. This unsupervised segmentation capability is considered important for mobile robots to learn spatial knowledge. The proposed HcVGH combines a convolutional variational autoencoder (cVAE) with HVGH, a past method, which follows the hierarchical Dirichlet process-variational autoencoder-Gaussian process-hidden semi-Markov model comprising deep generative and statistical models. In the experiment, FPV videos of an agent were used in a simulated maze environment. FPV videos contain spatial information, and spatial knowledge can be learned by segmenting them. Using the FPV-video dataset, the segmentation performance of the proposed model was compared with previous models: HVGH and hierarchical recurrent state space model. The average segmentation F-measure achieved by HcVGH was 0.77; therefore, HcVGH outperformed the baseline methods. Furthermore, the experimental results showed that the parameters that represent the movability of the maze environment can be learned.
Intravesical Gentamicin: An Option for Therapy and Prophylaxis against Recurrent UTIs and Resistant Bacteria in Neurogenic Bladder Patients on Intermittent Catheterization
Authors: Andretta Elena , Longo Raffaele , Balladelli Massimo , Sgarabotto Camilla , Sgarabotto Dino
Published: September 2022

This is a retrospective study of our experience with Gentamicin intravesical instillation as therapy and prophylaxis in patients with lower urinary tract infections (UTIs) undergoing clean intermittent catheterization because of a neurogenic bladder. It is an alternative therapy when all other systemic treatments have failed as it is still an off-label prescription.
Role of Sirtuins in Physiology and Diseases of the Central Nervous System
Authors: Chojdak-Łukasiewicz Justyna , Bizoń Anna , Waliszewska-Prosół Marta , Piwowar Agnieszka , Budrewicz Sławomir , Pokryszko-Dragan Anna
Published: September 2022

Silent information regulators, sirtuins (SIRTs), are a family of enzymes which take part in major posttranslational modifications of proteins and contribute to multiple cellular processes, including metabolic and energetic transformations, as well as regulation of the cell cycle. Recently, SIRTs have gained increased attention as the object of research because of their multidirectional activity and possible role in the complex pathomechanisms underlying human diseases. The aim of this study was to review a current literature evidence of SIRTs’ role in the physiology and pathology of the central nervous system (CNS). SIRTs have been demonstrated to be crucial players in the crosstalk between neuroinflammation, neurodegeneration, and metabolic alterations. The elucidation of SIRTs’ role in the background of various CNS diseases offers a chance to define relevant markers of their progression and promising candidates for novel therapeutic targets. Possible diagnostic and therapeutic implications from SIRTs-related investigations are discussed, as well as their future directions and associated challenges.
Association between Age-Related Macular Degeneration and the Risk of Diabetes Mellitus: A Nationwide Cohort Study
Authors: Jung Wonyoung , Yoon Je Moon , Han Kyungdo , Kim Bongseong , Hwang Sungsoon , Lim Dong Hui , Shin Dong Wook
Published: September 2022

Age-related macular degeneration (AMD) is a degenerative and progressive disease of the macula, the part of the retina that is responsible for central vision. AMD shares some risk factors with diabetes mellitus (DM), but little is known about the risk of DM in individuals with AMD. With the goal of establishing novel perspectives, this study aimed to investigate the association between AMD and the risk of DM using the Korean Nationwide Health Insurance Database. Individuals aged ≥ 50 years who underwent a national health screening program in 2009 were enrolled. Participants were categorized by the presence of AMD and visual disability (VD). The Cox hazard regression model was used to examine hazard ratios (HRs) of DM with adjustment for potential confounders. Stratified analyses by age, sex, and comorbidities (hypertension or dyslipidemia) were also performed. During a mean follow-up of 8.61 years, there were 403,367 (11.76%) DM incidences among the final 3,430,532 participants. The crude HR (95% confidence interval (CI)) was 1.16 (1.13–1.20) for AMD. After adjusting for potential confounders, AMD was associated with a 3% decreased risk of DM (aHR 0.97, 95% CI 0.95–1.00), but no significant association with the risk of DM was found in AMD with VD (aHR 1.03, 95% CI 0.93–1.14). In summary, we did not find an increased risk of DM in individuals with AMD. A 3% decreased risk of DM in patients with AMD is not clinically meaningful. Our study suggests that the association between AMD and the risk of DM is weak, considering the potential confounders. Further studies examining this association are needed to extend our knowledge.
Current Advances in the Management of Diabetes Mellitus
Authors: Aloke Chinyere , Egwu Chinedu Ogbonnia , Aja Patrick Maduabuchi , Obasi Nwogo Ajuka , Chukwu Jennifer , Akumadu Blessing Oluebube , Ogbu Patience Nkemjika , Achilonu Ikechukwu
Published: September 2022

Diabetes mellitus (DM) underscores a rising epidemic orchestrating critical socio-economic burden on countries globally. Different treatment options for the management of DM are evolving rapidly because the usual methods of treatment have not completely tackled the primary causes of the disease and are laden with critical adverse effects. Thus, this narrative review explores different treatment regimens in DM management and the associated challenges. A literature search for published articles on recent advances in DM management was completed with search engines including Web of Science, Pubmed/Medline, Scopus, using keywords such as DM, management of DM, and gene therapy. Our findings indicate that substantial progress has been made in DM management with promising results using different treatment regimens, including nanotechnology, gene therapy, stem cell, medical nutrition therapy, and lifestyle modification. However, a lot of challenges have been encountered using these techniques, including their optimization to ensure optimal glycemic, lipid, and blood pressure modulation to minimize complications, improvement of patients’ compliance to lifestyle and pharmacologic interventions, safety, ethical issues, as well as an effective delivery system among others. In conclusion, lifestyle management alongside pharmacological approaches and the optimization of these techniques is critical for an effective and safe clinical treatment plan.
Lighter and Simpler Design Paradigm for Widespread Use of Ankle Exosuits Based on Bio-Inspired Patterns
Authors: Park Sungjin , Moon Junyoung , Park June il , Ryu Jaewook , Nam Kimoon , Yang Jaeha , Lee Giuk
Published: September 2022

Soft wearable robots are attracting immense attention owing to their high usability and wearability. In particular, studies on soft exosuits have achieved remarkable progress. Walking is one of the most basic human actions in daily life. During walking, the ankle joint has considerable influence. Therefore, an exosuit design paradigm having a light and simple structure was developed with the goal of fabricating a soft exosuit that supports the ankle. The new exosuit matches the performance of existing exosuits while being as comfortable as everyday wear. A walking test through a combination with a mobile actuator system, which can maximize these advantages, was also conducted. The combination with the mobile system demonstrates the potential of using the new ankle exosuit as inner wear that maximizes the advantages of a lighter and simpler design. The exosuit design paradigm could serve as an effective guideline for manufacturing assistive exosuits for various body parts in the future.
Predicting Successful Throwing Technique in Judo from Factors of Kumite Posture Based on a Machine-Learning Approach
Authors: Kato Satoshi , Yamagiwa Shinichi
Published: September 2022

Identifying the key points of a movement performed by an expert is required for beginners who want to acquire a motor skill. By repeating a learning cycle, the beginner tries the movement, focusing on the key points. We can find many guiding methods for adopting motor skills in the fields of coaching and training for sports. However, the methods strongly depend on the experience of trainers and coaches, who need to select the appropriate methods for different types of athletes. Although methods based on objective information obtained from videos and sensors applicable to individual movements have been proposed in order to overcome the subjectivity of these approaches, we cannot apply those to movements that include external factors, such as pushing and/or attacks from an opponent, as seen in combat sports. Furthermore, such sports require fast feedback of the analysis to the athletes in order to find the key factors of offensive/defensive techniques at the training site. Focusing on judo throwing techniques, this paper proposes a novel real-time prediction method called RT-XSM (Real-Time Extraction method for Successful Movements) that predicts which throwing technique is most likely to be successful based on Kumite posture just before the throw. The RT-XSM uses logistic regression to analyze datasets consisting of the factors of Kumite posture (a standing posture when both players grip each other) and throwing technique classification. To validate the proposed method, this paper also demonstrates experiments of the RT-XSM using datasets acquired from video scenes of the World Judo Championships.
Peripheral Osteoma of the Mandibular Condyle—Case Series
Authors: Tilaveridis Ioannis , Katopodi Theodora , Karakostas Panagiotis , Venetis Gregory , Dimitrakopoulos Ioannis , Tilaveridis Stavros , Tilaveridou Sofia , Zarampouka Katerina
Published: September 2022

The purpose of this article is to present four new cases of peripheral osteoma of the mandibular condyle and the literature review. A retrospective study of files from our Department of Oral and Maxillofacial Surgery over the last 6 years revealed four cases of peripheral osteomas located in the area of the mandibular condyle. Diagnostic procedure included clinical, radiographic, and histologic criteria. Gardner’s syndrome was excluded from patient history and clinical evaluation. One patient had only an aesthetic disturbance, with facial swelling, and the other three patients presented disturbances of the mandibular function, including deviation during mouth opening along with malocclusion. Three of the patients were male and one was female; all were of middle age (45–65 years old). The proposed surgical treatment was accepted by half of the patients, while the remaining half declined the operation after a confirmation of the diagnosis. Peripheral osteomas of the maxillofacial region are uncommon, and some cases with multiple osteomas are related to Gardner’s syndrome. An osteoma of the mandibular condyle is very rare and surgical treatment is challenging for the surgeon with regards to the approach selection and the related complications. In the two cases that accepted the proposed surgical treatment, no recurrence and no complication was observed.
Using Geographic Information to Analyze Wildland Firefighter Situational Awareness: Impacts of Spatial Resolution on Visibility Assessment
Authors: Mistick Katherine A. , Dennison Philip E. , Campbell Michael J. , Thompson Matthew P.
Published: September 2022

Wildland firefighters must be able to maintain situational awareness to ensure their safety. Crew members, including lookouts and crew building handlines, rely on visibility to assess risk and communicate changing conditions. Geographic information systems and remote sensing offer potential solutions for characterizing visibility using models incorporating terrain and vegetation height. Visibility can be assessed using viewshed algorithms, and while previous research has demonstrated the utility of these algorithms across multiple fields, their use in wildland firefighter safety has yet to be explored. The goals of this study were to develop an approach for assessing visibility at the handline level, quantify the effects of spatial resolution on a lidar-driven visibility analysis, and demonstrate a set of spatial metrics that can be used to inform handline safety. Comparisons were made between elevation models derived from airborne lidar at varying spatial resolutions and those derived from LANDFIRE, a US-wide 30 m product. Coarser resolution inputs overestimated visibility by as much as 223%, while the finest-scale resolution input was not practical due to extreme processing times. Canopy cover and slope had strong linear relationships with visibility, with R2 values of 0.806 and 0.718, respectively. Visibility analyses, when conducted at an appropriate spatial resolution, can provide useful information to inform situational awareness in a wildland fire context. Evaluating situational awareness at the handline level prior to engaging a fire may help firefighters evaluate potential safety risks and more effectively plan handlines.
The Importance of Soil on Human Taphonomy and Management of Portuguese Public Cemeteries
Authors: Silva-Bessa Angela , Madureira-Carvalho Áurea , Dawson Lorna , Ferreira Maria Teresa , Dinis-Oliveira Ricardo Jorge , Forbes Shari L.
Published: September 2022

Cemeteries from the European Romantic period (18th–19th centuries) are often compared to small cities that hold memories, art, and history. Portuguese public cemeteries were first established in 1835 and became an interesting combination of fauna, flora, and monumental sculptures to mourn the dead at a location outside the limits of the city. Over the past 187 years, laws have been created and amended taking into consideration the needs of the population and the scientific knowledge available at each time point in history. Nevertheless, cemeteries have long been struggling with the lack of burial space which has been emphasised during the two years of the COVID pandemic. This work aims to review the development of Portuguese public cemeteries since their establishment, highlighting the imposed measures for the inhumation and exhumation of the deceased. It will also discuss the importance of soil as an abiotic agent, focusing on eight specific soil properties and their significance on the characterisation of graves. It is expected that a better understanding of the impact of soil on human taphonomy supports the role of city halls in managing public cemeteries, particularly the lack of burial space.
“In Truth, They Are My Masters”: The Domestic Threat of Early Modern Piracy
Authors: Jones Susan
Published: September 2022

Thomas Walton (known as Purser) and Clinton Atkinson (known as Clinton) were hanged for piracy in 1583. This article examines a range of texts relating to Purser and Clinton, including court depositions, plays and ballads, to consider the ways in which their lives and deaths were depicted and discover what this might tell us about contemporary attitudes towards piracy. Purser and Clinton were based in Dorset where the boundaries delineating piracy as an illegal activity were blurred and the local beneficiaries of piracy spanned the social hierarchy, reaching as high as nobility and the Admiralty. A wealth of textual evidence details the links between the maritime and littoral networks which sustained their activities, enabled their rise to prominence, and engineered their ultimate downfall. In reading together both official documents and popular printed texts this article reveals some of the complex networks which supported and were supported by piracy and, in doing so, locates the figure of the pirate within wider discourses of society, governance and mobility.
Long-Term Effects of Hospitalization for COVID-19 on Frailty and Quality of Life in Older Adults ≥80 Years
Authors: Covino Marcello , Russo Andrea , Salini Sara , De Matteis Giuseppe , Simeoni Benedetta , Pirone Flavia , Massaro Claudia , Recupero Carla , Landi Francesco , Gasbarrini Antonio , Franceschi Francesco
Published: September 2022

Objectives: This study aimed to assess the effects of frailty and the perceived quality of life (QOL) on the long-term survival (at least 1 year) of patients ≥ 80 years hospitalized for COVID-19 and the predictors of frailty and QOL deterioration in survivors. Design: This is a single-center, prospective observational cohort study. Setting and Participants: The study was conducted in a teaching hospital and enrolled all COVID-19 patients ≥80 years old consecutively hospitalized between April 2020 and March 2021. Methods: Clinical variables assessed in the Emergency Department (ED), and during hospitalization, were evaluated for association with all-cause death at a follow-up. Frailty was assessed by the clinical frailty scale (CFS), and the QOL was assessed by the five-level EuroQol EQ-5d tool. Multivariate Cox regression analyses and logistic regression analyses were used to identify independent factors for poor outcomes. Results: A total of 368 patients aged ≥80 years survived the index hospitalization (age 85 years [interquartile range 82–89]; males 163 (44.3%)). Compared to non-frail patients (CFS 1–3), patients with CFS 4–6 and patients with CFS 7–9 had an increased risk of death (hazard ratio 6.75 [1.51, 30.2] and HR 3.55 [2.20, 5.78], respectively). In patients alive at the 1-year follow-up, the baseline QOL was an independent predictor of an increase in frailty (OR 1.12 [1.01, 1.24]). Male sex was associated with lower odds of QOL worsening (OR 0.61 [0.35, 1.07]). Conclusions and Implications: In older adults ≥80 years hospitalized for COVID-19, the frailty assessment by the CFS could effectively stratify the risk of long-term death after discharge. In survivors, the hospitalization could produce a long-term worsening in frailty, particularly in patients with a pre-existing reduced baseline QOL. A long-term reduction in the perceived QOL is frequent in ≥80 survivors, and the effect appears more pronounced in female patients.
Clinical Usefulness of the Valsalva Manoeuvre to Improve Hemostasis during Thyroidectomy
Authors: Pacilli Mario , Pavone Giovanna , Gerundo Alberto , Fersini Alberto , Ambrosi Antonio , Tartaglia Nicola
Published: September 2022

Bleeding after total thyroidectomy remains a rare event that affects early postoperative morbidity, occurring in 0.3% to 4.2% of cases. Intraoperative bleeding is an unpleasant complication, and it is often easily manageable, although postoperative bleeding may represent a life-threatening condition for the patient. The purpose of our study was to clarify the role of the Valsalva manoeuvre to reduce postoperative bleeding. Between January 2019 to February 2022, 250 consecutive patients were listed for thyroid surgery at our surgical department. The study cohort consisted of 178 patients, divided into two groups based on the execution of the Valsalva manoeuvre. There was no difference in the duration of surgery between groups. Group B had fewer reinterventions for bleeding. Group A had a significantly greater volume of drainage output than Group B. Cervical haematoma can compromise a patient’s life, so bleeding control is crucial. Our results show that using a simple and safe Valsalva manoeuvre can improve the postoperative course with a significant reduction in drainage output, but does not prevent the risk of reoperation for hemorrhage.
Frontiers in Retinal Image Processing
Authors: Lakshminarayanan Vasudevan , Jidesh P.
Published: September 2022

Visual impairment is considered as a primary global challenge in the present era [...]
AUV Path Planning Algorithm for Terrain Aided Navigation
Authors: Zhang Wenjun , Shen Peng , Qi Haodong , Zhang Qianyi , Ma Teng , Li Ye
Published: September 2022

Terrain aided navigation (TAN) technology can yield accurate navigation results in long-endurance underwater operation of autonomous underwater vehicles (AUVs). Most TAN research focus on the high-precision terrain matching algorithms. However, terrain matching algorithms estimate the position of the vehicle by observing a unique combination of features in the terrain, making it difficult to locate a vehicle with flat terrain. This paper presents a path planning method for AUV seabed TAN process to decrease positioning errors by avoiding flat areas. In this paper, a TAN path planning algorithm based on sector search is proposed. Parameters of the sector search algorithm are determined through theoretical analysis, which means the generated path can stably provide accurate TAN location results. Meanwhile, a control coefficient is proposed to maximize the terrain information contained in the sector searching area, bring out a high success rate of AUV positioning. The TAN performance of the paths generated using the proposed path planning method was verified in simulations, which show that the TAN can yield accurate positioning results stably on the path planned.
Polar Wax as Adhesion Promoter in Polymeric Blend Films for Durable Photovoltaic Encapsulants
Authors: Baiamonte Marilena , Morici Elisabetta , Colletti Claudio , Dintcheva Nadka Tz.
Published: September 2022

Technological developments in the solar photovoltaic field must guarantee the high performance and low deterioration of solar cells in order for solar power plants to be more efficient and competitive. The solar cell needs comprehensive protection offered by a polymeric encapsulant, which improves UV stability, reduces water and moisture absorption, reduces oxygen and vapor permeability and enhances mechanical resistance. Moreover, high transparency and adhesion yields improved the solar panel performance. The current work analyzes polymeric films based on poly(ethylene-co-vinyl acetate) (EVA) and polyolefin (PO) for photovoltaic encapsulant use (the high temperature resistance is improved by adding PO to EVA, as investigated and documented before). To enhance the mechanical resistance and optical properties of the investigated matrices, a crosslinking agent, an adhesion promoter and stabilizing agents have been incorporated in both EVA and EVA/PO systems. The adhesion promoter is a polar wax–silane-free agent; the absence of the silane function allows the integrity of the module to be maintained over time. All samples were characterized through mechanical and rheological analysis, and their long-term UV stability was investigated by accelerated ageing and by FTIR and UV–vis spectroscopy. The obtained results suggest that the presence of a crosslinking agent, an adhesion promoter and stabilizers in EVA/PO-based films allows for the achievement of the required features for the encapsulants, showing mechanical and rheological behavior similar to those of EVA containing the same additives.