bluuebunny/crossref_metadata_2025 huggingface dataset:
Leading for Transformation: Navigating the Shifting Landscape of Work
Authors: Westover Jonathan
Published: August 2024

Leading for Transformation - Navigating the Shifting Landscape of Work is a groundbreaking book that serves as a compass for leaders who are navigating the ever-changing landscape of work. In this insightful and thought-provoking guide, renowned leadership expert Jonathan H. Westover, PhD, provides a roadmap for leaders to embrace the challenges and opportunities presented by the dynamic world of work. Drawing upon extensive research and real-world examples, Dr. Westover explores the critical role of transformational leadership in driving organizational success amidst constant change. He offers practical strategies, actionable insights, and powerful frameworks that empower leaders to adapt, innovate, and thrive in an environment where the only constant is change. From understanding the forces reshaping the workplace to developing a forward-thinking and agile mindset, this book equips leaders with the tools they need to lead their teams and organizations through transformational change. Dr. Westover delves into topics such as fostering a culture of continuous learning, embracing technology and automation, and nurturing a resilient workforce that embraces change. Whether you are a seasoned executive, a middle manager, or an aspiring leader, Leading for Transformation - Navigating the Shifting Landscape of Work offers valuable guidance for anyone seeking to make a lasting impact in today's rapidly evolving world of work. Packed with practical advice and thought-provoking questions, this book invites leaders to reflect, challenge their assumptions, and step into their role as catalysts for positive change. If you are ready to embrace the shifting landscape of work and lead your organization to new heights, this book is an essential resource that will inspire and empower you to become a transformational leader. Take the first step towards leading for transformation and unlock the full potential of your leadership.
Leading with Purpose: Navigating Change, Cultivating Collaboration, and Prioritizing Well-being in Today's Workplace
Authors: Westover Jonathan
Published: August 2024

Work is constantly evolving, and organizations need to equip their leaders with the tools to navigate change while fostering employee engagement, productivity, and well-being. In this book, leadership expert Jonathan H. Westover lays out a roadmap for establishing purpose-driven leadership in uncertain times. Drawing from research and case studies, Westover outlines strategies for developing a coaching mindset, creating a culture of open communication and collaboration, and embedding well-being practices into daily work. He provides templates, checklists, and examples to help leaders implement an agile and growth-oriented leadership approach. Readers will learn how to craft a compelling vision that inspires action, set measurable goals to track progress, and translate strategy into clear action steps. They will also discover tactics to facilitate breakthrough thinking, resolve conflicts constructively, and establish an environment where learning from failure is expected. Ultimately, Westover coaches leaders on how to lead with empathy, integrity and resilience -- traits essential for navigating constant change while elevating performance and engagement. For any executive seeking to inspire their organization to reach new levels of success, this book delivers a practical roadmap for purposeful leadership in today's shifting business landscape.
Balancing It All: Overcoming Emotional Exhaustion from Work-Family Conflicts
Authors: Westover Jonathan
Published: August 2024

This research brief examines the issue of work-family conflict and emotional exhaustion experienced by many female employees attempting to balance work and family responsibilities. The brief reviews the key drivers of work-family conflict according to academic literature, such as inflexible workplace cultures, unpredictable schedules, gender biases, and unequal division of labor at home. Practical strategies are then presented for overcoming emotional exhaustion, including promoting flexibility and boundaries, cultivating a respite culture, enhancing paternal support, and setting reasonable expectations. Specific case examples across industries provide pragmatic recommendations for effective implementation. The brief concludes with a call for organizational leaders and researchers to advocate evidence-based solutions that empower female employees' wellbeing and maximize their career potential through genuinely supportive work-life integration practices.
The Insidious Effects of Toxic Leadership
Authors: Westover Jonathan
Published: August 2024

This article discusses the detrimental impacts of toxic leadership on both individual and organizational outcomes. Toxic behaviors from those in positions of authority undermine trust, engagement, well-being, productivity, motivation and overall performance within teams. Three particularly damaging leadership styles are defined - abrasive, narcissistic, and authoritarian. Toxic leadership is shown to erode important team dynamics like trust, psychological safety, cohesion and motivation. Strategies for healing toxic organizational cultures are presented, focusing on open communication, accountability, training, cultural shifts through mission/values and leadership storytelling, and succession planning when necessary. The insidious costs of toxicity are described as permeating daily interactions and objective accomplishment. Although remedying deeply entrenched toxicity takes diligence, prioritizing a culture of psychological safety, trust and cooperation is asserted as superior for high quality work, satisfaction and long-term success.
Utilization of Kine Master Application as a Learning Video
Authors: Erwin Erwin , Japakiya Rusdee , Saputra Dedi
Published: August 2024

Background. The subject of natural science at the level of elementary school education grade 3 semester 1 is to learn about living things.
Purpose. The purpose of this article is to find out what methods or media are suitable for students during the Covid-19 pandemic. Then the technology that can be utilized in the learning process so that educators and students can still meet virtually during the learning process
Method. The technique used in this investigation is an approximation technique by surveying the school before the online teaching process is carried out with the aim of seeing what kind of methods and media are used by educators at the elementary school.
Results. In the first part, it can be recapitulated that 90% of learners cannot understand the learning provided through WhatSapp Group. In the second part, it can be recapitulated that 96% of students can understand the learning well, the learning process takes place through the Zoom Meeting application by displaying learning media in the form of videos created and edited using the KineMaster application. 4% of the learners experienced problems during the learning process. They are constrained by the network and do not have a HandPhone so that the video displayed during learning in the Zoom Meeting is sent back to the WhatSapp Group of class 3.
Conclusion. Kine master app can be used during online learning with the help of zoom app or other learning video apps.
Effectiveness of Learning Videos Using Inshot Application
Authors: MoHa Luqman , Sulaimah Saleh Ummu , Prasetya Utama Panji
Published: August 2024

Background. Optimizing video-based online media during the covid-19 pandemic for distance learning for students in understanding learning materials to produce optimal value and strong understanding.
Purpose. Based on the background and conditions at this time which are still in a pandemic that the learning process is still semi-online, it is hoped that a learning media that is appropriate and effective for sharing student knowledge. error one media that can be used is a learning video.
Method. In this study the authors used a type of qualitative research . type of research uses qualitative research with interview methods. This interview method consists of various groups including irregular, non-standard, casual, or focused interviews ranging from ordinary to specialized questions. Semi-structured Interviews. The interview will begin with easy questions about the subject or research we are doing to the interviewees we will ask. Structured or standardized interviews
Results. The result of this research is that the effectiveness of using learning video media in elementary school 02 tanjung bonai, north lintau buo sub-district, flat land district is very effective due to an increase in the quality and quality of education in the school.
Conclusion. The effectiveness of using learning video media in elementary school 02 tanjung bonai, north lintau buo sub-district, flat land district is very effective due to an increase in the quality and quality of education in the school.
Utilization of Canva Application as Making Thematic Learning Videos
Authors: Fiidznillah Rizki , Cholila Zahiratu , Nurlatipah Nurlatipah
Published: August 2024

Background. This discussion is about the use of canva software as a thematic learning video for Class V Semester I Theme two Subtheme 1 Learning three at State Elementary School 05 IX Koto, Dharmasraya Regency
Purpose. Is the purpose of this study, namely to explore how the utilization of canva software in making learning videos for teachers and the impact of thematic learning videos on Class V Semester 1 Theme 2 Subtheme 1 Learning 3 students at State Elementary School 05 IX Koto.
Method. The research uses participatory observation techniques and in-depth interviews that are spiked using data collection using describing the features of the canva software
Results. that the utilization of the canva application as a thematic learning video for Class V Semester 1 Theme 2 Subtheme 1 Learning 3 at negri 05 IX Koto basement school, Dharmasraya Regency, can be said to be successful.
Conclusion. Based on the results of the research that has been done, it can be concluded that the canva application-based learning video is very feasible to use in learning. The use of learning videos is very interesting for students so that students are motivated to carry out learning. In the covid-19 pandemic, online learning emphasizes the development of online-based learning media such as the use of the canva application in making learning media in the form of learning videos can provide new meaning and color for students in the learning process in thematic learning Class V Semester 1 Theme 2 Subtheme 1 Learning 3 at negri 05 IX Koto basic shool, Dharmasraya Regency which is effective, creative and innovative.
Utilization of Kinemaster Application in Improving Learning Outcomes
Authors: Sulaiman Agus , Muklis Fauzan , Patry Him
Published: August 2024

Background. They are constrained by the network and do not have a HandPhone so that the video displayed during learning in the Zoom Meeting is sent back to the WhatSapp Group of class 3.
Purpose. The purpose of this article is to find out what methods or media are suitable for students during the Covid-19 pandemic. Then the technology that can be utilized in the learning process so that educators and students can still meet virtually during the learning process.
Method. The technique used in this investigation is an approximation technique by conducting a survey of the school before the online teaching process is carried out with the aim of seeing what kind of methods and media are used by educators at the elementary school. Then pay attention to the reaction of students at the first meeting of learning in this investigation. After that, analyze and find solutions so that learning runs effectively without discomfort and disinterest of students in the learning process.
Results. In the first part, it can be recapitulated that 90% of learners cannot understand the learning provided through WhatSapp Group. In the second part, it can be recapitulated that 96% of students can understand the learning well, the learning process takes place through the Zoom Meeting application by displaying learning media in the form of videos created and edited using the KineMaster application. 4% of the learners experienced problems during the learning process.
Conclusion. This investigation is detailed into 2 parts, in the first part, the application and the way of learning that is applied are not effective, in the second part all obstacles are corrected so that it can be concluded that the learning media created through the KineMaster application in the form of videos and shared through the Zoom Meeting application really causes a positive reaction to students.
User response of learning application Arabic language
Authors: Amiruddin Muhammad
Published: August 2024

Background. Accelerating the mastery of a second language is a challenge for the majority of students and academics. Interactive applications for learning foreign languages that look attractive, the material is appropriate, easy aka practical, muted and accelerative are certainly very much needed and sought after. I have distributed and researched this Arabee application made in Turkish during arabic learning at the Ulul Albab campus of Universitas Islam Negeri Malang.
Purpose. This study aims to introduce and see the response to the Arabee Arabic language learning application.
Method. The data collection method used by researchers is dominated by questionnaires. This research was structured with qualitative methods. The research sample was taken from various students of Islamic Universities and Arabic language activists in the country.
Results. The results of this study indicate that the performance of the arabee application (alifbee now) is so captivating. The systematic learning topics raised in this application are appropriate and closely related to current trends. The use of this application is easy to operate. It is hoped that this application can appear in the future in the Indonesian-Arabic version.
Conclusion. The appearance of the arabee or alifbee application has captured many hearts, especially campus academics at the university / institute level in Indonesia. The systematic learning topics raised in this application, judging from the respondents' input, have a good level of suitability and relevance and or are very related to current trends and life.
Arabic Language Learning Program Management of Madrasah Tsanawiyah Fadhilah Pekanbaru
Authors: Fitri Ramadhaniati , Ajiji Lubis Muhammad , Wahyudi Hakmi
Published: August 2024

Background. This research was conducted to examine the effectiveness of Arabic language learning program management at Madrasah Tsanawiyah Fadhilah Pekanbaru. Focusing on the aspects of planning, organizing, implementing, and monitoring, the research aims to improve the quality of Arabic language learning and ensure conformity with the vision and mission of the madrasah.
Purpose. The study aims to evaluate and improve the management of Arabic language learning program at Madrasa Tsanawiyah Fadhilah Pekanbaru. The focus is on optimizing the planning, organization, implementation, and supervision of the program to achieve effectiveness and efficiency in achieving the vision and mission of Arabic language education in the madrasah..
Method. This descriptive qualitative research aims to find out the management of the Arabic language program at MTs Fadhilah Pekanbaru. Data collection uses interviews with the principal, observation, and documentation about the management of Arabic language programs at madrasah tsanawiyah  Fadhilah Pekanbaru.
Results. Madrasah Tsanawiyah  Fadhilah uses the functions of program management studies in implementing the Arabic language learning program for all students so that this program runs effectively and efficiently, namely: 1) Planning the Arabic language learning program in preschool children through the needs identification stage. 2) Organizing in this school is the coach as the head of the foundation who holds the highest power. 3) The implementation of the Arabic language learning program in preschool children is by preparing teachers, making learning process plans (RPP).
Conclusion. The success of the Arabic language learning program at Madrasah Tsanawiyah Fadhilah Pekanbaru hinges on effective management functions. Consistency with the foundation's vision and mission is maintained through thorough planning, well-organized implementation, and direct supervision, highlighting the critical role of management in program success.
The Urgency and Functions of Arabic Language Learning in Educational Institutions
Authors: Rusydi Amar Fathur
Published: August 2024

Background. This research explores the background of the importance of learning Arabic, a Semitic language with over 280 million speakers as a first language. Influenced by aspects of religiosity and internationality, Arabic has a significant role in culture, Islamic religion and international relations.
Purpose. This research aims to understand the role and urgency of Arabic in a global context, covering religious, cultural and diplomatic aspects. It aims to analyze the development of the Arabic language from historical aspects to contemporary developments, as well as identify its impact as an international language involving non-Muslims. This research also intends to explore a deeper understanding of the importance of learning Arabic outside the religious context, focusing on its functional diversity and use in the modern world.
Method. The research method involves literature analysis, Arabic language learning needs survey, and implementation case studies in educational institutions to understand the urgency and function of Arabic language learning.
Results. The importance of learning Arabic for Muslims is reflected in three main aspects: the understanding of Islamic teachings, the unification of Muslims, and human civilization. Arabic is the main source of knowledge, especially in understanding Islamic religious sources. Moreover, it plays a key role in uniting the global Muslim community, facilitating communication and enhancing unity.
Conclusion. There are many benefits that will be gained if Muslims learn Arabic. Among them, first, fahmul Islam (understanding Islamic teachings). By mastering Arabic, of course it will be very easy for us to understand most of Islamic teachings. Because the sources of Islamic teachings (the Koran, hadith, and books written by ulama) use Arabic. Allah SWT said, "Indeed, We made the Qur'an in Arabic so that you understand.
Madrasah Education Strategies To Build Student Discipline At Amaliyah Private Aliyah Madrasah Tanjung Tiga
Authors: Nur Nisa Br Tj Anggi
Published: August 2024

Background. This study describes the madrasah education strategy to build student discipline at the private madrasah aliyah amaliyah tanjung tiga.
Purpose. The purpose of the research is to inform and educate readers that formal educational institutions, namely madrasah, have the ability to shape the character of a disciplined student.
Method. This type of research is qualitative research that seeks to describe social phenomena that are developing in the masses today. The data collection techniques used are observation and unstructured interviews, then the data is analyzed objectively and described scientifically by following the procedures for writing scientific papers.
Results. The research results found are as follows:  First, private madrasah aliyah amaliyah tanjung tiga teachers on various occasions always educate students to always comply with the rules and regulations that apply in the madrasah environment.  Second, private madrasah aliyah amaliyah tanjung tiga teachers always provide exemplary examples of discipline to students so that they become role models for them. Third, private madrasah aliyah amaliyah tanjung tiga teachers always carry out internal supervision of the character of students and student discipline, if there are still students who are not disciplined, madrasah teachers conduct early identification of the triggers for these students to become undisciplined Fourth, the head of the private madrasah aliyah amaliyah tanjung tiga conducts periodic evaluations to all madrassa residents which aim to improve things that must be improved for the next day. Fifth, efforts to establish student discipline are carried out in persuasive ways.
Conclusion. Madrasah Aliyah Swasta Amaliyah Tanjung Tiga applies an educational approach in enforcing student discipline. Sanctions are educational in nature, including assignments, written reports to parents, suspension, and temporary or permanent deactivation. The habituation of disciplinary attitudes involves arriving on time, homework, manners, and development activities, with optimal support from students' families.
The Influence Of The Teacher's Ability To Use Computer-Based Media On Student Attention In Islamic Religious Education Learning At Public Junior High School (SMPN) 2 Sidrap
Authors: Hijaz Tahir Muhammad , Arsal Hijaz Muhammad , Hermansyah Sam
Published: August 2024

Background. Computer-based media enhances material acceptance and retention, facilitating teachers in efficient material storage and direct student engagement. Utilizing visuals and audio, it directly appeals to sight and hearing senses. Hence, the research titled "Effect of Computer-based Media Proficiency on Attention in Islamic Religious Education for Class VIII at Public Junior High School 2 Sidrap" is pertinent.
Purpose. Based on some of these definitions both linguistically and in terms, teachers can be understood as people who are responsible for the development of students. Where the task of a teacher is to educate, namely to strive for the development of all the potential of students, both cognitive potential, affective potential and psychomotor potential.
Method. This field research employs direct data collection and observation from respondents, falling under the quantitative category for obtaining objective, valid, and reliable numerical or scaled data. Utilizing associative research methods, its focus lies in establishing relationships between two or more variables.
Results. The distributed questionnaires among students at Public Junior High School 2 Sidrap Regency revealed diverse attitudes toward the teacher's proficiency in utilizing computer-based learning media for Islamic Religious Education. Descriptive statistical analysis was employed to present and summarize the data through frequency distribution tables, aiming to provide a comprehensive overview aligned with the research objectives and variable descriptions.
Conclusion. The study concludes that, based on questionnaire responses from 97 participants at Public Junior High School 2 Sidrap Regency, the teacher's proficiency in utilizing computer-based media for Islamic Religious Education learning (variable X) is at 79.9%, categorizing it as moderate. This determination is derived from a ratio of 7444 to 9312, signifying the identified criterion.
The Impact of The Environment and Leadership Patterns on Employee Work Achievement At Uptd Region Viii Samsat Langsa
Authors: Eryani Eryani
Published: August 2024

Background. This study describes the impact of the environment and leadership patterns on employee work achievement at the Technical Implementation Unit (UPTD) region VIII of the Langsa samsat.
Purpose. The purpose of this study is to educate readers and measure the extent of environmental impact and work achievement patterns of employees.
Method. This study uses multiple linear regression analysis methods, used to determine the independent variable on the dependent variable. Researchers used the help of the SPSS (Statistical Product and Service Solution) program so that the results obtained were more directed. The number of samples studied was 21 respondents. The analysis used includes percentage calculation, partial test (t-test), correlation test, significance test and coefficient of determination test.
Results. The results of the study found that the impact of the environment and leadership patterns on the achievement of employee work at UPTD region VIII samsat Langsa is in good criteria with the results of the analysis reaching factors that affect performance, namely the leadership variable has an average of 4.56 and the work environment variable has an average of 4.39. In addition, based on the hypothesis which states that there is a significant effect of leadership on employee performance, it is proven to be true in the partial test (t test) the t-count result for the leadership variable is 1.867 and the value in the 5% distribution table is 1.697. And partially the work environment variable has more influence on employee performance with the results of t count 4.987.
Conclusion. The conclusion of research at UPTD region VIII Samsat Langsa, it can be concluded that leadership and work environment have a significant effect on employee performance. Leadership has a positive influence, while the work environment is more dominant in influencing employee performance, indicated by a higher t value.
Effect Of Use Of The Focusky Application On Results Learning Arts And Culture For Class X Students Madrasah Aliyah Ddi Kulo
Authors: Aini Aini , M Usman , B Hasanuddin , Hermansyah Sam
Published: August 2024

Background. Researchers will examine the impact of the Focusky app on Arts and Culture learning for 10th-grade students at Madrasah Aliyah DDI Kulo. Pre-observation reveals conventional teaching methods in use. The introduction of Focusky is expected to enhance learning, offering a dynamic experience for both students and teachers.Top of Form.
Purpose.This study on the use of the Focusky application in Arts and Culture education for 10th-grade students at Madrasah Aliyah DDI Kulo is expected to contribute significantly. Findings may enhance teaching methods, particularly in the Arts, improving overall learning quality and simplifying the educational process.
Method.This use method approach quantitative. According to Sugiyono (2017) study quantitative is "Method study Which based on the philosophy of positivism . Used to research populations or sample certain, collection data use instruments study, analysis data nature quantitative or statistics, with objective For test hypothesis Which has set.
Results.This research was carried out with the aim of finding out    whether there was an effect of using Focusky on the Arts and Culture learning outcomes of class X Madrasah Aliyah DDI Kulo students by   taking a sample of 26 class X Madrasah Aliyah DDI Kulo students. In determining the experimental and control group students used a totally  sampling technique system.
Conclusion.Based on the results of this research, several conclusions can be drawn as follows: The use of Focusky in the learning process has an influence on the Arts and Culture learning outcomes of class X Madrasah Aliyah DDI Kulo students. This is because by using Focusky teachers and students can carry out the teaching and learning process more easily and convey information to students well and interestingly.
Influence Use Media Based Canva On Learning Outcomes Of Citizenship Education Class Xi Students Of Private Senior High School (SMAS) Muhammadiyah Pangsid
Authors: Hikmah D Nur , Syamsunir Syamsunir , M Usman , Hermansyah Sam
Published: August 2024

Background. Based on the results of observations at Private Senior High School Muhammadiyah Pangsid, researchers saw that teachers still used the lecture method in the learning process with voices that were not clear during the learning process. And media which used Still depend on book package Which less interesting so students feel bored and cannot concentrate on what the teacher is saying. With Canva- based media , it is hoped that it can help the teaching and learning process can be implemented well.
Purpose. The research focuses on Canva as a presentation-based learning tool with diverse templates to boost student interest in the material. Observations at Private Senior High School Muhammadiyah Pangsid revealed a concern: low student interest affecting learning quality and school credibility. Addressing this issue is crucial for enhancing overall educational outcomes.Top of Form.
Method. The research This research uses an experimental type of research. Sugiyono explained that "Method study experiment can  interpreted as research methods used to find the effect of certain   treatments towards others in controlled conditions” (Anggoro, 2016).
Results. The results of the experimental group that used Canva- based media in the learning process obtained higher scores compared to the group control Which No using media based canva on moment learning process. Matter the can seen from the results acquisition analysis that data carried out shows the average value of the experimental group.
Conclusion. Research on the impact of Canva in teaching Citizenship Education to Class XI at Private Senior High School Muhammadiyah Pangsid shows positive results. With an average score of 83.214, significantly higher than the control group's 65, and a t-test result of 8.204 exceeding the critical value, Canva positively influences Citizenship Education outcomes.
Idiomatic Phrase Processing in Arabic "A Psycholinguistic Study"
Authors: Hidayat Rahmat , Sulaimah Saleh Ummu , Satya Ivan , Wargadinata Wildana
Published: August 2024

Background. The background of this study is to explore psycholinguistic methods to assist Arabic language learners in processing idiomatic phrases more effectively. The focus is on identifying cognitive strategies that can improve the understanding and use of idiomatic phrases in communicative contexts. By solving this problem, it is hoped that learners can become more proficient in the idiomatic aspects of Arabic, improve communication skills, and feel confident interacting with native speakers.
Purpose. The main objective of this study is to investigate the psycholinguistic aspects of Arabic idiomatic phrase processing, exploring cognitive strategies in non-native and native learners. The research aims to identify factors that influence comprehension, such as proficiency, culture, and learning experience, focusing on technology-based teaching methods to improve mastery.
Method. This study takes a psycholinguistic approach, using a quantitative survey to investigate the processing of Arabic idiomatic phrases. The research involves identifying phrases, designing a survey, and analyzing the data to enhance the insights of understanding, which contributes to the understanding of psycholinguistics.
Results. Research shows that learning Arabic in a formal environment has a positive impact on communication skills. The use of Arabic idiomatic phrases in daily life enriches communication. Online resources are dominant in understanding idiomatic phrases. The main obstacle is the difference in Arabic dialects. Psychological factors play an important role in the comprehension of idiomatic phrases and impact on overall Arabic language skills, especially in the context of social and professional communication.
Conclusion. His study concluded that learning Arabic in a formal environment, such as school or university, has a great effect on students' speaking ability. The use of idiomatic phrases is also recognized as enriching everyday communication.
Performance Enhancement of Electronic and Energy Devices via Block Copolymer Self‐Assembly
Authors: Yoo Hyeon Gyun , Byun Myunghwan , Jeong Chang Kyu , Lee Keon Jae
Published: June 2015

The use of self‐assembled block copolymers (BCPs) for the fabrication of electronic and energy devices has received a tremendous amount of attention as a non‐traditional approach to patterning integrated circuit elements at nanometer dimensions and densities inaccessible to traditional lithography techniques. The exquisite control over the dimensional features of the self‐assembled nanostructures (i.e., shape, size, and periodicity) is one of the most attractive properties of BCP self‐assembly. Harmonic spatial arrangement of the self‐assembled nanoelements at desired positions on the chip may offer a new strategy for the fabrication of electronic and energy devices. Several recent reports show the great promise in using BCP self‐assembly for practical applications of electronic and energy devices, leading to substantial enhancements of the device performance. Recent progress is summarized here, with regard to the performance enhancements of non‐volatile memory, electrical sensor, and energy devices enabled by directed BCP self‐assembly.
Self‐Assembly of Perovskite for Fabrication of Semitransparent Perovskite Solar Cells
Authors: Aharon Sigalit , Layani Michael , Cohen Bat‐El , Shukrun Efrat , Magdassi Shlomo , Etgar Lioz
Published: June 2015

This work reports on the preparation of semitransparent perovskite solar cells. The cells transparency is achieved through a unique wet deposition technique that creates perovskite grids with various dimensions. The perovskite grid is deposited on a mesoporous TiO2 layer, followed by hole transport material deposition and evaporation of a semitransparent gold film. Control of the transparency of the solar cells is achieved by changing the perovskite solution concentration and the mesh openings. The semitransparent cells demonstrate 20–70% transparency with a power conversion efficiency of 5% at 20% transparency. This is the first demonstration of the possibility to create a controlled perovskite pattern using a direct mesh‐assisted assembly deposition method for fabrication of a semitransparent perovskite‐based solar cell.
ABCG2 overexpression in patients with acute myeloid leukemia: Impact on stem cell transplantation outcome
Authors: Damiani Daniela , Tiribelli Mario , Geromin Antonella , Michelutti Angela , Cavallin Margherita , Sperotto Alessandra , Fanin Renato
Published: June 2015

ABGG2 protein overexpression in acute myeloid leukemia (AML) has been associated with poor response to conventional chemotherapy and increased relapse risk. No data are available on the role of allogeneic stem cell transplantation (SCT) in reversing its negative prognostic role. We have reviewed the outcome of 142 patients with high risk AML who underwent allogeneic SCT in complete remission (n =94) or with active disease (n =48). Patients with ABCG2 overexpression at AML diagnosis have lower leukemia free survival (LFS) and increased cumulative incidence of relapse (CIR) compared with ABCG2− patients (5‐year LFS 50% vs. 65%,P =0.01; 5‐year CIR 46% vs. 27%,P =0.003). Five‐year overall survival was not significantly different between ABCG2+ and ABCG2− patients (39% vs. 51%,P =0.1). However, if we consider only disease‐related deaths, ABCG2 maintains its negative role (64% vs. 78%,P =0.018). The negative impact of ABCG2 overexpression was higher in patients undergoing SCT in CR compared with patients receiving transplant with active disease. Conditioning regimen did not abrogate the effect of ABCG2 overexpression, as CIR was higher in ABCG2+ patients receiving both myeloablative (44% vs. 22%,P =0.018) or reduced intensity conditioning (50% vs. 32%,P =0.03). In conclusion, ABCG2 overexpression at AML diagnosis identifies a subset of patients with poor outcome also after allogeneic SCT, mainly in terms of higher relapse rates. Prospective studies employing conditioning drugs or post‐transplant strategies able to target ABCG2 are needed to maximize the curative potential of stem cell transplantation.Am. J. Hematol. 90:784–789, 2015. © 2015 Wiley Periodicals, Inc.
Synthesis, Properties, and Packing Structures of Corannulene‐Based π‐Systems Containing Heptagons
Authors: Kato Kenta , Segawa Yasutomo , Scott Lawrence T. , Itami Kenichiro
Published: June 2015

Introduction of heptagons into hexagonal carbon lattices can generate negatively curved polycyclic aromatic hydrocarbons, which are of significant interest in the field of exotic molecular nanocarbons. We have successfully synthesized and characterized corannulene‐based π‐systems containing heptagons (4 and 5) as new negatively curved polycyclic aromatic hydrocarbons as well as possible intermediates in the synthesis of warped nanographene 1. The formation of 4 and 5 represents the first example for which a heptagon is formed under Scholl reaction conditions before all hexagons are formed. Even more interestingly, we discovered that the mode and degree of solid‐phase intermolecular π–π interaction can be altered significantly by the degree of ring closure.
Occupational EMF exposure from radar at X and Ku frequency band and plasma catecholamine levels
Authors: Singh Sarika , Kapoor Neeru
Published: June 2015

Workers in certain occupations such as the military may be exposed to technical radiofrequency radiation exposure above current limits, which may pose a health risk. The present investigation intended to find the effect of chronic electromagnetic field (EMF) exposure from radar on plasma catecholamines in the military workforce. In the study, 166 male personnel selected randomly were categorized into three groups: control (n = 68), exposure group‐I (X‐band, 8–12 GHz, n = 40), and exposure group‐II (Ku‐band, 12.5–18 GHz, n = 58). The three clusters were further divided into two groups according to their years of service (YOS) (up to 9 years and ≥10 years) to study the effect of years of radar exposure. Enzyme immunoassay was employed to assess catecholamine concentrations. EMF levels were recorded at different occupational distances from radar. Significant adrenaline diminution was registered in exposure group‐II with no significant difference in exposure group‐I when both groups were weighed against control. Nor‐adrenaline and dopamine levels did not vary significantly in both exposure groups when compared to controls. Exposure in terms of YOS also did not yield any significant alteration in any of the catecholamines and in any of the exposure groups when compared with their respective control groups. The shift from baseline catecholamine values due to stress has immense significance for health and well‐being. Their continual alteration may prove harmful in due course. Suitable follow‐up studies are needed to further strengthen these preliminary observations and for now, exposures should be limited as much as possible with essential safeguards. Bioelectromagnetics. 36:444–450, 2015. © 2015 Wiley Periodicals, Inc.
Accessible Synthetic Probes for Staining Actin inside Platelets and Megakaryocytes by Employing Lifeact Peptide
Authors: Cardo Lucia , Thomas Steve G. , Mazharian Alexandra , Pikramenou Zoe , Rappoport Joshua Z. , Hannon Michael J. , Watson Stephen P.
Published: June 2015

Lifeact is a 17‐residue peptide that can be employed in cell microscopy as a probe for F‐actin when fused to fluorescent proteins, but therefore is not suitable for all cell types. We have conjugated fluorescently labelled Lifeact to three different cell‐penetrating systems (a myristoylated carrier (myr), the pH low insertion peptide (pHLIP) and the cationic peptide TAT) as a strategy to deliver Lifeact into cells and developed new tools for actin staining with improved synthetic accessibility and low toxicity, focusing on their suitability in platelets and megakaryocytes. Using confocal microscopy, we characterised the cell distribution of the new hybrids in fixed cells, and found that both myr– and pHLIP–Lifeact conjugates provide efficient actin staining upon cleavage of Lifeact from the carriers, without affecting cell spreading. This new approach could facilitate the design of new tools for actin visualisation.
Continuous Hydrogenation of Toluene over Sr‐ and PEG800‐Modified Ni/γ‐Al2O3 Catalysts
Authors: Chu Hailong , Li Na , Niu Libo , Liu Chen , Qiu Mande , Bai Guoyi
Published: June 2015

A series of γ‐Al2O3‐supported nickel‐based catalysts were evaluated in continuous hydrogenation of toluene. Sr‐ and poly(ethylene glycol) 800 (PEG800)‐modified Ni/γ‐Al2O3 catalysts provided the best activity with high conversion of toluene and selectivity for methylcyclohexane which was ascribed to the addition of Sr and PEG800 during the preparation process, resulting in smaller and highly dispersed Ni species on the surface and in the pores of γ‐Al2O3. Furthermore, the formation of SrCO3 and NiAl2O4 is believed to be advantageous for the dispersion and stabilization of the active Ni species, accounting for its good stability.
Two Analytical Approaches for Solution of Population Balance Equations: Particle Breakage Process
Authors: Hasseine Abdelmalek , Senouci Samra , Attarakih Menwer , Bart Hand‐Jörg
Published: June 2015

Various particulate systems were modeled by the population balance equation (PBE). However, only few cases of analytical solutions for the breakage process do exist, with most solutions being valid for the batch stirred vessel. The analytical solutions of the PBE for particulate processes under the influence of particle breakage in batch and continuous processes were investigated. Such solutions are obtained from the integro‐differential PBE governing the particle size distribution density function by two analytical approaches: the Adomian decomposition method (ADM) and the homotopy perturbation method (HPM). ADM generates an infinite series which converges uniformly to the exact solution of the problem, while HPM transforms a difficult problem into a simple one which can be easily handled. The results indicate that the two methods can avoid numerical stability problems which often characterize general numerical techniques in this area.
Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research
Authors: Lewis T , Dinh J , Leeder JS
Published: June 2015

Opiate‐dependent pregnant women receive opiate maintenance medications to prevent illicit use and withdrawal. Fetal opiate exposure causes central nervous system (CNS) alterations which manifest as postnatal physical withdrawal. The extensive variability in the Neonatal Abstinence Syndrome phenotype remains unexplained and may be related to variability in fetal exposure and response. Improved understanding of functionally significant genetic variants in pathways influencing placental opiate transfer and fetal response can lead to personalized maternal therapy and optimized neonatal outcomes.
Academic Attainment in Students with Dyslexia in Distance Education
Authors: Richardson John T. E.
Published: June 2015

This investigation studied attainment in students with dyslexia or other specific learning difficulties who were taking modules by distance learning with the Open University in 2012. Students with dyslexia or other specific learning difficulties who had no additional disabilities were just as likely as nondisabled students to complete their modules, but they were less likely to pass the modules that they had completed and less likely to obtain good grades on the modules that they had passed. Students with dyslexia or other specific learning difficulties who had additional disabilities were less likely to complete their modules, less likely to pass the modules that they had completed and less likely to obtain good grades on the modules that they had passed than were nondisabled students. Nevertheless, around 40% of students with dyslexia or other specific learning difficulties obtained good grades (i.e. those that would lead to a bachelor's degree with first‐class or upper second‐class honours). Copyright © 2015 John Wiley & Sons, Ltd.
Alterations of the spindle checkpoint pathway in clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas
Authors: Arai Eri , Gotoh Masahiro , Tian Ying , Sakamoto Hiromi , Ono Masaya , Matsuda Akio , Takahashi Yoriko , Miyata Sayaka , Totsuka Hirohiko , Chiku Suenori , Komiyama Motokiyo , Fujimoto Hiroyuki , Matsumoto Kenji , Yamada Tesshi , Yoshida Teruhiko , Kanai Yae
Published: June 2015

CpG‐island methylator phenotype (CIMP)‐positive clear cell renal cell carcinomas (RCCs) are characterized by accumulation of DNA hypermethylation of CpG islands, clinicopathological aggressiveness and poor patient outcome. The aim of this study was to clarify the molecular pathways participating in CIMP‐positive renal carcinogenesis. Genome (whole‐exome and copy number), transcriptome and proteome (two‐dimensional image converted analysis of liquid chromatography‐mass spectrometry) analyses were performed using tissue specimens of 87 CIMP‐negative and 14 CIMP‐positive clear cell RCCs and corresponding specimens of non‐cancerous renal cortex. Genes encoding microtubule‐associated proteins, such as DNAH2, DNAH5, DNAH10, RP1 and HAUS8, showed a 10% or higher incidence of genetic aberrations (non‐synonymous single‐nucleotide mutations and insertions/deletions) in CIMP‐positive RCCs, whereas CIMP‐negative RCCs lacked distinct genetic characteristics. MetaCore pathway analysis of CIMP‐positive RCCs revealed that alterations of mRNA or protein expression were significantly accumulated in six pathways, all participating in the spindle checkpoint, including the “The metaphase checkpoint (p = 1.427 × 10−6),” “Role of Anaphase Promoting Complex in cell cycle regulation (p = 7.444 × 10−6)” and “Spindle assembly and chromosome separation (p = 9.260 × 10−6)” pathways. Quantitative RT‐PCR analysis revealed that mRNA expression levels for genes included in such pathways, i.e., AURKA, AURKB, BIRC5, BUB1, CDC20, NEK2 and SPC25, were significantly higher in CIMP‐positive than in CIMP‐negative RCCs. All CIMP‐positive RCCs showed overexpression of Aurora kinases, AURKA and AURKB, and this overexpression was mainly attributable to increased copy number. These data suggest that abnormalities of the spindle checkpoint pathway participate in CIMP‐positive renal carcinogenesis, and that AURKA and AURKB may be potential therapeutic targets in more aggressive CIMP‐positive RCCs.
Sensitivity of chemical reaction networks: a structural approach. 2. Regular monomolecular systems
Authors: Fiedler Bernold , Mochizuki Atsushi
Published: June 2015

M. Otani Dedicated to Messoud Efendiev on the occasion of his 60th birthday

For the deceptively innocent case of monomolecular reactions, only, we embark on a systematic mathematical analysis of the steady‐state response to perturbations of reaction rates. Our structural sensitivity analysis is based on the directed graph structure of the monomolecular reaction network, only. In fact our function‐free approach does not require numerical input. We work with general, not necessarily monotone reaction rate functions. Based on the graph structure alone, we derive which steady‐state concentrations and reaction fluxes are sensitive to, and thus affected by, a rate change—and which are not. Moreover we establish a transitivity property for the influence of a rate perturbation, at any reaction, on all reaction fluxes. The results and concepts developed here, from a mathematical view point, are of applied relevance including metabolic networks in biology; see our companion paper quoted below. Copyright © 2015 John Wiley & Sons, Ltd.