bluuebunny/crossref_metadata_2025 huggingface dataset:
Asymptomatic congenital intrahepatic portosystemic shunt
Authors: Sidorov E. A. , Zelter P. M. , Solovov D. V. , Manukyan А. А.
Published: September 2022

Spontaneous asymptomatic intrahepatic portosystemic shunt is a rare anomaly of the hepatic vasculature. The main clinical manifestations may be encephalopathy, bleeding or hyperinsulinism, due to the constant shedding of blood. This article presents a case of an asymptomatic congenital intrahepatic portosystemic shunt, found in patient I., aged 25, with the results of various imaging methods, as well as an analysis of the main types of the described vascular anomaly.
Characterization of Salt Quality from Artemia (Artemia franciscana) Cultured Water with Dunaliella salina as Natural Feed
Authors: Islamiyah Himna Sayyyidatul , Mochammad Amin Alamsjah  , Laksmi Sulmartiwi
Published: September 2022

The high demand for domestic salt cannot be achieved by local salt production from traditional salt and PT. Garam fluctuates every year. In addition, the quality of traditional salt is still low. This causes the need for domestic salt consumption to be met by imported salt. Therefore, it is necessary to have an alternative to meet the domestic salt demand, namely the revitalization of salt ponds for the development of mass Artemia cultivation that produces both Artemia production and biomass and produces salt in one location. In its natural habitat, Artemia uses microalgae as its main food source. The quality of microalgae feeds greatly determines the production of Artemia franciscana. The availability of nutrients is a factor that determines the rate of growth, so the amount and quality of feed are the main factors to meet the nutritional content for optimal development. Therefore, the salt production in this study used saltwater cultured Artemia with Dunaliella salina as a natural feed with a water age of 3rd,7th, and 14th days. This study aimed to determine the best age of Artemia water cultured with Dunaliella salina as a natural feed in salt production. The results showed that the different ages in Artemia water cultured with Dunaliella salina had a significant effect (p < 0.05) on salt characteristics. The best result was D7 which is salt from Artemia cultured water with Dunaliella salina as a natural feed with water age 7th day. Their respective values are 0.66a + 0.33 water content, 91.55 + 0.32 NaCl, 0.87 water-insoluble part, 0.39% + 0.01 Ca, and 1.25a + 0.05 Mg.
Preoperative atrial fibrillation/flutter impact on risk-adjusted repeat aortic intervention patients
Authors: Novotny Samantha , Dokko Julia , Zhang Xiaoyue , Agha Sohaib , Yaligar Ashutosh , Kolba Natalie , Tummala Vineet , Parikh Puja B. , Pryor Aurora D. , Tannous Henry J. , Shroyer A. Laurie , Bilfinger Thomas
Published: September 2022

Aim: Impacts of pre-operative atrial fibrillation or flutter (AF/AFL) upon repeat aortic valve replacement (r-AVR) patients’ risk-adjusted short-term outcomes is unknown. Methods: From 2005-2018, New York State AF/AFL versus non-AF/AFL adults’ risk-adjusted r-AVR outcomes were compared. Primary endpoints included the Society of Thoracic Surgeons’ 30-day operative mortality or major morbidity (MM) composite and 30-day readmission (READMIT); the MM sub-components were secondary endpoints. Multivariable logistic regression models evaluated AF/AFL impact upon these endpoints while holding other factors constant. Results: Of 36,783 adults initially undergoing aortic valve replacement, 334 subsequently underwent r-AVR. Within this r-AVR group, 42.4% of repeat surgical (r-SAVR) patients had AF/AFL; 50.4% of repeat transcatheter (viv-TAVR) patients had AF/AFL. R-SAVR AF/AFL patients were older and had more comorbidities than those without AF/AFL. Viv-TAVR AF/AFL patients were similar to those without AF/AFL except for lower rates of chronic obstructive pulmonary disease. Comparing risk-adjusted r-AVR outcomes, AF/AFL did not impact MM [odds ratio (OR), 95% confidence interval (CI): 1.23, 0.66-2.28, P = 0.512] or READMIT (OR, 95% CI: 1.15, 0.60-2.19, P = 0.681). Black race (OR, 95% CI: 2.89, 1.01-8.32, P = 0.049) and Elixhauser mortality score (OR, 95% CI: 1.07, 1.04-1.10, P < 0.0001) predicted MM risk. Cerebrovascular disease (OR, 95% CI: 2.54, 1.23-5.25, P = 0.012) predicted READMIT risk, while viv-TAVR was protective compared to r-SAVR (OR, 95% CI: 0.44, 0.21-0.91, P = 0.027). Conclusion: AF/AFL was not associated with risk-adjusted short-term r-AVR outcomes. Black race, Elixhauser mortality score, and cerebrovascular disease predicted adverse outcomes.
A cigarette filter-derived nitrogen-doped carbon nanoparticle coating layer for stable Zn-ion battery anodes
Authors: Guo Yi , Liu Cheng , Xu Lei , Huang Kaixin , Wu Hao , Cai Wenlong , Zhang Yun
Published: September 2022

Despite the low cost, safety and high theoretical capacity of metallic zinc, zinc anodes face chronic problems, including zinc dendrites, corrosion and side reactions in aqueous zinc-ion batteries (ZIBs). Herein, a nitrogen-doped carbon nanoparticle coating layer derived from discarded cigarette filters is constructed to suppress parasitic side reactions and zinc dendrite growth. The dense coating layer isolates water from the zinc anode, effectively inhibiting side reactions. Furthermore, the special micro-mesoporous structure and sufficient zincophilic groups guarantee uniform Zn stripping/plating. Consequently, durable cycle stability (2400 cycles at a current density of 1 mA cm-2) with a stable polarization potential is achieved for symmetrical cells. The coating layer derived in this study therefore has the potential to improve the electrochemical performance of ZIBs.
seconde marque et le consommateur moyen de vin. Commentaire de l’arrêt « Maucaillou », CA Bordeaux, 6e ch., 30 juin 2022.
Authors: Raffray Ronan
Published: September 2022

Dans ce riche arrêt rendu le 30 juin 2022, la chambre des appels correctionnels de la Cour d’appel de Bordeaux confirme le jugement du tribunal correctionnel de Bordeaux du 12 décembre 2019, rendu dans ce qu’il convient d’appeler l’« affaire Maucaillou », première d’une série qui a vu des acteurs de la filière poursuivis du chef de pratiques commerciales trompeuses pour avoir vendu des vins de négoce en s’appuyant sur une référence à une exploitation du vignoble bordelais.
Relasi Kewenangan Pemerintah Pusat dan Pemerintah Daerah dalam Penataan Kawasan Metropolitan Jabodetabek-Punjur
Authors: Wardhana Allan Fatchan Gani , Huda Ni’matul
Published: September 2022

The arrangement concept and development of the Metropolitan Area poses as one of the most interesting issues relating to local government law. Although the Regional Government Law provides flexibility for local governments to regulate and manage their regional affairs, in the Metropolitan Areas however, the Central Government takes part in structuring the regulations and institutions. This study examines two issues, namely the regulation of Metropolitan Areas in Indonesia and the relation of authority between the Central Government and Regional Governments in the arrangement of the Jakarta-Bogor-Depok-Tangerang-Bekasi-Puncak-Cianjur Metropolitan Area. This study uses a normative juridical method. The results of the study conclude that first, regulations regarding Metropolitan Areas are spread across various instruments, namely Legislations, Government Regulations, Provincial Regulations, and Regency/City Regional Regulations. Second, in structuring the Jabodetabek Metropolitan Area, the Central Government still dominates, while the Regional Government only needs to carry out what is the will of the Central Government. This dominance can be seen in the aspects of regulatory formation and management of Metropolitan Areas.
Factors Influencing the Decision of an Islamic Boarding School to Choose Face-to-Face Learning During Pandemic
Authors: Aziz Abdul , Purwastuti Lusila Andriani , Marzuqi Muhammad Ali Baidlowi , Bahrudin Aceng , Ariyunita Noorrela
Published: September 2022

This study highlights the factors influencing face-to-face learning decision-making by an Islamic boarding school during the pandemic. This qualitative descriptive-analytic study was conducted at MA Miftahunnajah, Sleman. Interviews, documentation, and observations were used to collect data. The research revealed that the following factors influenced face-to-face learning decisions: 1) internal conditions, such as boarding school security, student order, parental involvement, geographic location, and curriculum structure; 2) information availability; 3) external conditions, including community involvement and collaboration with other schools; 4) personality and skills of decision-makers. In addition, the Islamic boarding school's security was the most influential factor in all these factors, so facilitating schools with dormitories or boarding schools as places for students to live and study is a more appropriate solution than forcing online learning.
The Implementation of Sorogan Methods for Santri Islamic Boarding School in Classical Islamic Book (Kitab Kuning)
Authors: Suteja Suteja , Saifuddin Saifuddin , Sanusi Sanusi , Mubarokah Laelah Al
Published: September 2022

THE IMPLEMENTATION OF SOROGAN METHODS FOR SANTRI   ISLAMIC BOARDING SCHOOL IN CLASSICAL ISLAMIC BOOK (KITAB KUNING). This study is to investigate the quality of students' literacy of Kitab Kuning through the Sorogan method. To collect the data, observation was conducted in twenty Pesantren in West Java and in-depth interviews with Kiai, santri, alumni, and some local societies around the pesantren. The data collected was then analyzed with a descriptive narrative. This study found that the level of santri’s literacy to understand Kitab Kuning decreased. It was aligned with the change of teaching methods from the Sorogan to the classical method. This issue has a negative impact on the process of transferring knowledge such as misconception to understand Islamic law.
Multicultural School Management in the Development of Religious Inclusiveness Culture in SMK Bhakti Karya Parigi West Java
Authors: Niam Zainun Wafiqatun , Sholihah Daimah
Published: September 2022

Education as a sub-culture of society should be able to contribute to building harmony above differences, especially religious differences. One of the efforts that can be taken in this regard is the practice of multicultural school management. The existence of multicultural school management shows that schools officially recognize diversity through policies to organize and accept this diversity. Through the implementation of multicultural school management at SMK Bhakti Karya Parigi Pangandaran, West Java, it is hoped that education will be able to contribute to developing religious inclusiveness in social life. The method used in this research was field research using a qualitative approach. The main subjects in this study were the principal and manager of SMK Bhakti Karya Parigi Pangandaran, West Java. In this study, the material object was SMK Bakti Karya Parigi, and the formal object was multicultural school management in developing inclusive religious culture. Data collection techniques used participatory observation, interviews, documentation, and data triangulation. Meanwhile, the data analysis employed the Spradley model data analysis technique with domain, taxonomy, componential, cultural, and triangulation analysis. The results revealed that the implementation of multicultural school management at SMK Bakti Karya has included all management functions, from planning, organizing, implementing, and supervising schools and one of the results of the multicultural school management practice is the development of religious inclusiveness culture in the school environment and the community. It can be proven by the school's ability to accommodate differences, especially religious differences, in the school environment to reach school goals together.
Development of Fiqh Learning Based on Islamic Boarding Schools MA KMM Kauman Padang Panjang West Sumatra
Authors: In'ami Moh , D Derliana , Vestia Etika , Setiawan Ade
Published: September 2022

Learning of Fiqh, in general, has not been able to strengthen the characteristics of Islamic boarding school. Besides, learning of Fiqh in particular, has other significant problems: a) The number of teaching hours for Fiqh based on Islamic boarding school is insufficient); b) Reference books based on Islamic boarding school has not been used and utilized); c) There are no examples of integrated learning between madrasah and Islamic boarding schools, and d) There are not many graduates who continue their studies at university majoring in religion. This research aims to produce an example for learning of Fiqh based on Islamic boarding schools that can be implemented classically in classroom and halaqah in dormitories of MA KMM Kauman Padang Panjang. In order to achieve this goal, the author uses a Research and Development (R&D) development model. Which is well-known as a 4D development model.  In practice, this development model consists of several stages, define, design, develop, and disseminate.
Orientasi Pragmatis dan Idealis dalam Pendidikan Islam: Kajian Kurikulum Madrasah Aliyah Nurul Qur’an Simo Boyolali
Authors: Sumadi Eko
Published: September 2022

The formulation of the problem that will be answered in this article is how do the leaders and managers of MA Nurul Qur'an respond and answer future challenges through curriculum innovations and educational programs held? This study uses qualitative methods, with 7 respondents, namely; the leader of the pesantren (kyai), the head of the MA, the deputy head of the curriculum, the teacher, and 3 students. Data collection techniques in the form of interviews, observation, and documentation. The data analysis techniques include data reduction, data presentation, and verification or concluding. The discussion in this article concludes, that as a pesantren-based madrasa, the manager of MA Nurul Qur'an is committed to educating students (Santri) so that they can grow into the Upper Middle Class through three alumni profiles, becoming: Kyai, Priyai, and Entrepreneur. The three profiles are a top priority considering that future challenges for alumni will be more complex and require skills and specialization in certain areas of expertise. To encourage the creation of graduates with three alumni profiles, MA Nurul Qur'an made many modifications and developments to the curriculum based on Islamic boarding school values while also emphasizing the strengthening of foreign languages. Academically, this article contributes to providing an argument that the values of idealism and pragmatism can be combined as the basis for the development of Islamic educational institutions. While practically, this article contributes to providing an example for academics and education practitioners, regarding how the madrasa curriculum model is designed to accommodate the interests of idealism and pragmatism.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 27.08.2022 г. по 02.09.2022 г.
Authors: Дмитриева Людмила , Краснов Ярослав , Чумачкова Елена , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: September 2022

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 вызывающих озабоченность (VOC), геномные последовательности которых размещены в международной базе данных GISAID с 27.08.2022 г. по 02.09.2022 г.
Effect of Myofascial Induction Therapy in Pterygoid Muscles of Woodwinds and String Musicians on Muscular Stiffness of the Upper Trapezius
Authors: Suarez-Rodriguez Vidina , Loro-Ferrer Juan Francisco , Rodriguez-Ruiz David
Published: September 2022

PURPOSE: Considering the fascial continuity and its biomechanical characteristics, the purpose of this study was to assess the change in muscular stiffness (Dm) of the upper trapezius muscles after the application of myofascial induction therapy (MIT) to the masticatory muscles of musicians.
METHODS: This was a pre-posttest design involving one treatment. SUBJECTS: The total sample was 33 subjects (n = 33). The experimental group comprised 18 violin, viola, and woodwind players, and the control group was comprised of 15 non-musicians. The outcome measures included pre-posttest
measurements with tensiomyography of the upper trapezius (muscle stiffness, Dm), and baseline neck disability (Neck Disability Index), and pain (SF-36 questionnaire). The experimental group received MIT for 5 minutes on each side of the lateral pterygoid muscle. The control group assumed a
supine position for 10 minutes. RESULTS: After the intervention, there was a significant difference in Time per Group (F = 2.896, p = 0.034, 2p = 0.367, and w = 0.755). There were statistically significant differences in pre-post and side-by-side analyses for the Dm of the upper trapezius
in the experimental group as well as between the two groups. CONCLUSION: MIT of the lateral pterygoids is effective in decreasing upper trapezius stiffness as measured by an increase in the Dm measured by tensiomyography. The greatest change occurred in musicians with a lower percentage of
Neck Disability Index at baseline.
Incidence, Mechanisms, and Characteristics of Injuries in Pole Dancers: A Prospective Cohort Study
Authors: Nicholas J , Weir G , Alderson J A , Stubbe J H , van Rijn R M , Dimmock J A , Jackson B , Donnelly C J
Published: September 2022

OBJECTIVE: Pole dancing is a challenging physical activity. Prospective injury studies in pole dancing are lacking. The aim of this study was to describe the incidence, mechanisms, and characteristics of injuries in pole dancers. METHODS: A total of 66 pole dancers from 41 studios across
Australia were prospectively followed over 12 months. An intake questionnaire was administered including items on pole dancers’ demographics and training characteristics. Exposure was assessed using a daily online training diary. Self-reported injury data were collected via an incident
report form and subsequently coded using the Orchard Sports Injury Classification System. Injuries occurring during pole-specific and pole-related activities were included in the analyses. RESULTS: The sample included 63 females and 3 males, mean age 32.3 ± 8.9 years and mean pole training
experience 3.5 ± 2.8 years. 25 of 66 participants completed the full study. The 1-year incidence of all new injuries was 8.95/1,000 exposure hours (95% CI 6.94 – 10.96), 7.65/1,000 hrs (95% CI 5.79 – 9.51) for pole-specific injuries and 1.29/1,000 hrs (95% CI 0.53 –
2.06) for pole-related injuries. A total of 103 injuries occurred, 62.1% of which were sudden onset and 37.9% gradual onset. Mechanism of onset included 54.4% acute and 45.6% repetitive in nature. Shoulder (20.4%) and thigh (11.7%, majority ham¬string) were the most reported anatomic injury
sites. Non-contact mechanisms accounted for the majority of injuries (57.3%). The most reported primary contributor to injury onset at the shoulder were manoeuvres characterised by loaded internal humeral rotation (33.3%), and at the hamstring were manoeuvres and postures involving front splits
(100.0%). CONCLUSION: The findings indicate that pole dancers are at high risk for injuries. Future research is needed to understand the biomechani¬cal demand of manoeuvres and training characteristics of pole dancing (e.g., workload and recovery) to guide the development of preventative
interventions, particularly targeted toward the shoulder and hamstring.
Psychological Changes of Music and Fine Arts Students in the Education Process: A Comparative Longitudinal Study
Authors: Akdemir Meltem , Sönmez Yonca , Köse Fırat , Şenol Yeşim Yiğiter , Gürpınar Erol , Aktekin Mehmet Rıfkı
Published: September 2022

BACKGROUND: This study aimed to determine the changes in psychological distress, anxiety, and depressive symptoms in students from the fine arts faculty in the first 2 years of their education in Turkey, in comparison with students from other faculties, and to reveal the causes of psychological
distress, anxiety, and depression in fine arts students. METHODS: The General Health Questionnaire (GHQ-12), Beck Depression Inventory (BDI), and Spielberger State-Trait Anxiety Inventory (STAI) were applied to students from Faculty of Fine Arts and the Faculties of Economics and Sport Sciences
(controls) in the first week of the 2017–2018 academic year. Students also completed a questionnaire measuring their possible stressful life events (at timepoint T1). The process was repeated for the same students in the second year (T2). The changes between the two time¬points were
examined prospectively. RESULTS: A total of 96 fine arts students agreed to participate at T1 and 66 at T2 (68.8%); for the controls, it was 259 at T1 and 182 (70.3%) at T2. The fine arts students at T1 included 15 music majors, 45 cinema and television, and 36 handi¬crafts, sculpture,
and painting. Their average age at T1 was 21.0 yrs (SD 5.8) and 54.2% were male; for the other students, it was 19.4 yrs (2.7) and 56.0% male. Fine arts students’ GHQ-12 score averages increased significantly from T1 to T2 (11.7 to 14.3, p=0.002). Their BDI score averages increased from
10.3 to 12.3 (p=0.044). Moreover, their S-Anxiety score averages increased from 41.1 at T1 to 44.1 at T2 (p=0.008). However, the increase in T-Anxiety scores was not statistically significant. None of the control students’ test scores varied between the two timepoints (p>0.05). At
T2, for fine arts students, there was no significant difference between female and male students in terms of GHQ-12, BDI, and S-Anxiety scores. However, T-anxiety scores were higher in female students. By linear regression analysis, “worrying about the future (individual)” was
found to be a determinant on all scale scores in fine arts students. CONCLUSION: The psychological indicators increased significantly in fine arts students during the first year of their education.
Connecting Multilayer Semantic Networks to Data Lakes: The Representation of Data Uncertainty and Quality
Authors: Cayeux E. , Damski C. , Macpherson J. , Laing M. , Annaiyappa P. , Harbidge P. , Edwards M. , Carney J.
Published: September 2022

Drilling oil and gas wells is a complex process involving many disciplines and stakeholders. This process occurs in a context where some pieces of information are unknown, or are often incomplete, erroneous, or at least uncertain. Yet, during drilling engineering and construction of a well, drilling data quality and uncertainty are barely addressed in an auditable and scientific way. Currently, there are few or no placeholders in engineering and operational databases to document uncertainty and its propagation. The Society of Petroleum Engineers (SPE) has formed a cross-disciplinary technical subcommittee to investigate how to describe and propagate drilling data quality and uncertainty. The subcommittee is a cooperation between the drilling system automation, wellbore positioning, and drilling uncertainty prediction technical sections. As the topic is vast and complex, a systematic method was adopted, where multiple user stories or pain points were generated and ranked with the most compelling user story analyzed in detail. From this approach, a series of multidisciplinary workflows (drilling data generators) can now be captured and described in terms of data quality and propagation of uncertainty. The paper presents details of one user story focused on capturing the description of the quality and uncertainty of depth measurements. Multiple use cases have been extracted from this single user story exemplifying how multiple stakeholders and disciplines manage, communicate, and understand the notion of wellbore depth and its relative uncertainty. Current data stores have the main objective of recording the results of processes but have very limited capabilities to store how the interdisciplinary processes generated and cross-related these results. The study explores the use of semantic networks to capture those multidisciplinary data relationships. A minimum vocabulary has been created using just a few tens of concepts that has sufficient expressiveness to describe all the extracted use cases, showing that the semantic network method has the potential to describe a broad range of complex drilling-related processes. The study also demonstrates that use of a multilayered graph, employing other notions that do not expressly refer to the processes that generated the data, can capture the description of how uncertainty propagates between each of those concepts.
Influence of acetosolv and eco-friendly bleaching treatment of orange bagasse in biocomposites properties: A mechanical and thermal approach
Authors: Pereira Paulo Henrique Fernandes , Santos Liziane B Ubirajara , Monticeli Francisco , Cioffi Maria Odila H.
Published: September 2022

The development of efficient pre-treatments is widely used in biobased products to add value to the residue. For that purpose, this work aims to carry out fibers chemically extracted from the orange bagasse (Citrus sinensis) as reinforcement in polymeric matrix composites. The fibers were extracted by acetosolv, following two bleaching steps, to obtain fibers with properties that promote their use in polymer matrix composites. Orange bagasse untreated (OBU), orange bagasse untreated_acetosolv (OBAc), and acetosolv_bleaching (OBAc-B) were characterized by chemical composition, thermogravimetric analysis (TGA), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR). Biocomposites were prepared using a HIPS matrix with 15% reinforcement and chemically extracted orange bagasse fibers (OBU, OBAc, OBAc-B). XRD data showed that the OBAc-B has higher crystallinity indexes than OBU (15.1 to 48.3% OBAc-B). Mechanical behavior of composites OBU, OBAc, and OBAc-B present an oscillation on tensile, modulus, and strain as a function of the most appropriate reinforcement treatment (i.e., acetosolv without bleaching). Results indicate that all treatment factors used in this work are influential in the fiber mechanical, chemical, and thermal characteristics, as a promising approach to extract cellulose fibers from OBU and use them as a reinforcement for polymer matrix application.
Inhibition of the TLR4/NF-κB inflammatory pathway decreases the microglia-mediated overpruning of synapses to ameliorate the mechanism underlying brain injury after epileptic seizures
Authors: Wu Qiong , Wang Hua , Liu Xueyan , Zhao Yajuan , Zhao Xin , Su Peng , Miao Jianing
Published: September 2022

Objective: Brain injury after the onset of epilepsy is a neurological symptom that urgently needs to be addressed, and there is currently no effective treatment. Excessive synaptic pruning is one of the most important causes of this symptom, but the specific underlying mechanism is not clear. Methods: A pilocapine-induced rat model of epilepsy was established, and the rats were randomly divided into 4 groups: a control group, Epilepsy group, TLR4 inhibitor group (Epilepsy+TAK-242 group), and NF-κB antagonist group (Epilepsy+BAY11-7082 group). Semeiology was used to observe epilepsy in the rats, and conducted experiments Results: 1. Frequency of epileptic seizures and epileptic seizure grade: Compared with those in the EP group, the frequency and intensity of epileptic seizures in the EP+BAY group and the EP+TAK group were reduced to different degrees. 2. The Nissl staining results showed that the number of neurons in the TLR4 inhibitor group and NF-κB antagonist group was significantly higher than that in the epilepsy group. 3. CX3CR1 was most highly expressed in the Epilepsy group, with a statistically significant difference compared with CX3CR1 expression in the Ctrl, EP+BAY and EP+TAK group. 4. The expression of SYP and PSD95 was the lowest in the Epilepsy group, with a statistically significant difference. 5 The number of synapses in the hippocampus was significantly lower in the Epilepsy group, Epilepsy group and Control group, and the number of synapses in the EP + BAY and EP + TAK group was significantly different. 6. In the Morris water maze test, compared with the EP, the EP+BAY and EP+TAK groups exhibited reduced escape latency, increased of platform crossings, and increased time spent in the target quadrant. Conclusion: This study proved at the organization level that in epilepsy, the TLR4/NF-κB inflammatory pathway is inhibited, which decreases the expression of chemokine receptor CX3CR1, promotes the expression of presynaptic membrane proteins and postsynaptic membrane proteins, increases the number of synapses, improves the order of synaptic structures, inhibits microglia via abnormal synaptic pruning and synaptic E/I imbalances, and inhibits the occurrence and severity of epilepsy, thus ameliorating head injury after the onset of epilepsy.
Modelling Loan Classification as a Markov Chain
Authors: Gidigah Pascal , ODOI BENJAMIN
Published: September 2022

This paper examined the loan portfolio classification criteria with the application of discrete time Markov chain. Default Portfolio were classify under three stage; Sub-standard, Doubtful and Loss in R programming. We predicted that Import and export from some specific classes states is possible with certain probabilities and stationary states distribution of 38 percent sub-standard, 33 percent Doubtful and 27 percent loss of a given portfolio at specific time period.
New Type of Aeronautical Risk Assessment: Performance of Kohonen Self-Organizing Maps in Identifying Brazilian Aircraft with Greater Associated Risks
Authors: Silva Marcell Bruno Sousa e
Published: September 2022

The purpose of this paper is to present a new way of assessing aeronautical risk using a configuration of Kohonen Self-Organizing Maps (SOM) to identify the Brazilian aircraft more likely to be involved in aeronautical accidents and the riskiest Brazilian aircraft. The technique described is classified as predictive for managing aeronautical risks, according to DOC 9859, and can be used both in the context of prevention and investigation of aeronautical accidents/incidents, as well as in the context of the insurance industry. Using this technique, it was possible to identify the 147 Brazilian aircraft with the highest associated probabilities of occurrence of aeronautical accidents, and the 180 with the highest associated risks. Five years after this identification, the respective percentages of aeronautical accidents/incidents were 34% and 27%. The application of this technique can help achieve the objective of the aeronautical community in determining what, where, and when the next aeronautical accidents and/or incidents will occur. Another aspect of the present work is to demonstrate that data collected by the national civil aviation agency in Brazil can be used to implement a predictive methodology for the management of safety in civil aviation.
Performance Study of HF communication using NOMA over Narrowband HF Channel
Authors: Ismail Ahmad , Mohamedpour Kamal
Published: September 2022

HF systems are still important for many communication applications. Data can be sent for a long distance with low cost. One major drawback of them is their low bitrate. The aim of this paper is to increase the bit rate per HF narrowband channel using NOMA. Two parts of Data has been divided and sent for one user over two different power levels. In the receiver side these two parts Data are reorganized using NOMA technique. The results review that using NOMA in a Narrowband 3 kHz channels is reliable. Compared to the maximum rate proofed in previous works using conventional methods, the proposed method increases the rate by 45%. Combined with multichannel algorithms such as HF XL, the total increase in bit rate can be considerable. Results are validated with real experiments. The system is built on SDR plate form and tested in different channel conditions.
Effect of stocking density and vitamin E or zinc supplementation on growth, physiology, gene expression, and economic efficiency of growing broiler chicks
Authors: Shehata Seham F , Baloza Samar H , Elsokary Mohamed M.M. , Hashem Nesrein M. , Khawanda Maha M
Published: September 2022

A total of 636 one-day-old Cobb chicks were randomly assigned to seven treatments. The chicks were offered feed and water ad libitum throughout the experimental period. The first three groups included different stocking densities of broiler birds (low stocking density, LSD: 10 birds/m2; medium stocking density, MSD: 15 birds/m2; and high stocking density HSD: 17 birds/m2). The LSD group was considered a control group. The other four groups included MSD or HSD broiler birds supplemented with either Vit E (100 mg/kg DM diet; MSDVE and HSDVE) or Zn (100 mg/kg DM diet; MSDZn and HSDZn) in their basal diet. The main findings indicated that HSD and MSD negatively affected (p < 0.05) all variables under investigation compared with LSD. Compared with LSD, broiler birds in the MSD and HSD groups had lower body weights and higher feed conversion ratios, higher co ncentrations of blood plasma hormones (triiodothyronine thyroxine and corticosterone), and downregulated expression levels of hepatic growth hormone and insulin-like growth factor-l. In addition, broiler birds stocked at medium or high densities resulted in less economic return and profit. Vit E or Zn supplementation to broiler birds stocked at medium or high densities significantly reversed all adverse effects of HSD (>10 birds/m2) on growth performance, hormones, and gene expression. It could be recommended that adding Zn at a level of 100 mg/kg per DM diet allows increasing the stocking density of broiler birds from 10 birds/m2 to 15 birds/m2 while maintaining the birds, welfare, and economic profit.
Social worlds of attitudes towards anti-COVID-19 vaccination: a Multi-Sited Approach to contextualise a Society in Europe
Authors: Sandu Dumitru
Published: September 2022

What does the balance of attitudes towards the anti-COVID-19 vaccination look like in an eastern European Society? We compared what the Romanians in Romania, interviewed on the subject in the Flash Eurobarometer 494, say with what those from other European Union countries said. From the "discussion with the data" we understood that there are not only ani-vaxxers, pro-vaxxers, and hesitant. There are other categories that matter, between them. We tried to see how much it mattered, in the pro- or anti-vaccination beliefs, not only the usual demographic conditionings of education, age, gender, or residential environment, but also personal pre-pandemic vaccination experiences, as an adult, or trust in institutions relevant to the COVID-19 vaccination. How is the typical Romanian compared to the typical European from the perspective of the main factors of conditioning the attitude towards the anti-COVID-19 vaccination?
Exosomes from high glucose-treated macrophages promote epithelial–mesenchymal transition of renal tubular epithelial cells via long non-coding RNAs
Authors: Yang Huayu , Bai Yu , Fu Chen , Liu Wenhu , Diao Zongli
Published: September 2022

Background: Macrophages contribute to epithelial–mesenchymal transition (EMT) in diabetic nephropathy (DN). Exosomal long non-coding RNAs (lncRNAs) derived from macrophages play a major role in transmitting biological information, whereas related studies on DN are rare. Here we investigated the effects of exosomal lncRNAs from high glucose-treated macrophages on EMT. Methods: High glucose-treated macrophage exosomes (HG-exos) were extracted by coprecipitation and stabilized. Then, mouse renal tubular epithelial cells were treated with HG-exos for 24 hours. Expression of E-cadherin, α-smooth muscle actin (α-SMA), and fibronectin was detected by western blotting, qPCR, and immunofluorescence. High-throughput sequencing was then applied to analyze the bioinformatics of HG-exos. Results: HG-exos inhibited the proliferation of tubular epithelial cells. Additionally, HG-exos markedly upregulated α-SMA and fibronectin expression and downregulated E-cadherin expression in tubular epithelial cells, indicating EMT induction. A total of 378 differentially expressed lncRNAs and 674 differentially expressed mRNAs were identified by high-throughput sequencing of HG-exos. Bioinformatics analysis and subsequent qPCR validation suggested 23 lncRNAs were enriched in the EMT-related MAPK pathway. Among them, ENSMUST00000181751.1, XR_001778608.1, and XR_880236.2 showed high homology with humans. Conclusion: ﻿Exosomes from macrophages induce EMT in DN and lncRNAs in exosomes enriched in the MAPK signaling pathway may be the possible mechanism.
Torsional instability in suspension bridges: a simplified nonlinear model
Authors: ZURRU MARCO
Published: September 2022

A simplified nonlinear model for the dynamic behaviour of suspension bridges is proposed, based on sinusoidal shape functions. The model is applied to the understanding of torsional instability. Numerical experiments are performed using the structural parameters of the Tacoma Narrows Bridge, with initial conditions similar to those observed before the collapse. Each simulation spans about 30 minutes. In line with previous work, numerical results show how torsional instability depends on total energy, with a specific energy level required for each set of initial conditions to reach instability. The time before the onset of instability varies for each initial condition. Interestingly, the model indicates a lack of energy transfer to non-initially-excited even modes. The present numerical investigation confirms recent results, while the proposed model provides a simple and intuitive tool to simulate the relationship between design parameters and potential instability phenomena.
SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption
Authors: Aobulikasimu Alkebaier , Tao Liu , Piao Jinying , Sato Shingo , Ochi Hiroki , Okawa Atsushi , Tsuji Kunikazu , Asou Yoshinori
Published: September 2022

The mechanistic regulation of bone mass in aged animals is poorly understood. In this study, we examined the role of SIRT6, a longevity-associated factor, in osteocytes, using mice lacking Sirt6 in Dmp-1-expressing cells (cKO mice) and the MLO-Y4 osteocyte-like cell line. cKO mice exhibited increased osteocytic expression of Sost, Fgf23 and senescence inducing gene Pai-1 and the senescence markers p16 and Il-6, decreased serum phosphate levels, and low-turnover osteopenia. The cKO phenotype was reversed in mice that were a cross of PAI-1-null mice with cKO mice. Furthermore, senescence induction in MLO-Y4 cells increased the Fgf23 and Sost mRNA expression. Sirt6 knockout and senescence induction increased HIF-1α binding to the Fgf23 enhancer sequence. Bone mass and serum phosphate levels were higher in PAI-1-null aged mice than in wild-type mice. Therefore, SIRT6 agonists or PAI-1 inhibitors may be promising therapeutic options for aging-related bone metabolism disruptions.
“Pain Neuroscience Education as an Adjunct to Physiotherapy Protocol in Knee Osteoartritis”- A Case Report
Authors: Walimbe Vaibhavi , Kulkarni Yash , Deolankar Apurva , Chitapure Tajuddin
Published: September 2022

Background: Knee Osteoarthritis affects the entire joint, causing synovial inflammation, cartilage injury, bone remodeling, and the development of osteophytes. Pain, muscle fatigue, joint dysfunction, brief morning stiffness, crepitus, and functional limitations are the common symptoms of knee osteoarthritis.Pain Neuro Science Education (PNE) produces wonderful effects in altering the pain perception of patients by changing their perspective towards pain and reducing pain catastrophization.Methodology A 61 year old female primarily complaining of pain in her right knee (9 on NPRS) along with crepitus, swelling and painful knee flexionfor which shereceived conventional physiotherapy treatment (Cryotherapy, IFT, Ultrasound, strengthening exercises) along with pain neuroscience education PNE (Neurobiology of pain, Education about the pathology of OA, Audio visual aids 30 min session for 5 days Outcome measures were NPRS for pain, pain catastrophizing scale (PCS).Result: PNE has/was shown an additive effect on overall reducing pain and pain catastrophizing along with the conventional physiotherapy treatment.
Outcome of Percutaneous coronary intervention and associated factors among patients with coronary artery disease in selected public hospital Addis Ababa, Ethiopia, 2022; A cross-sectional study
Authors: Amdestion Niguse , Fetensa Getahun , Wondimu Mestawot , Bires Abebaw , Lameesa Fayisa , Haile Biruk
Published: September 2022

Background
Percutaneous coronary intervention is a non-surgical, invasive revascularization procedure of relieving the narrowing or occlusion of the coronary artery and improving blood supply to the ischemic tissue. However, in Ethiopia, limited numbers of research regarding outcomes of percutaneous coronary intervention, and most of them lack representativeness.
Objectives
The aim of this study is to assess the outcome of percutaneous coronary intervention and associated factors among patients with coronary artery disease in selected public hospitals in Addis Ababa.
Methods
Institutional-based cross-sectional study was conducted from January 2017 up to September 2021 GC in the coronary unit of the selected public and private hospitals. Records of patients from the coronary cardiac unit (n = 408) were reviewed and the sample size was allocated proportionally and subjects were selected by using a simple random sampling technique. The data were abstracted using a checklist and entered into Epi Data manager version 4.6 and statistical analyses were performed using the SPSS version 25. The strength of association was assessed using odds ratio and Variables that had a value of P ≤ 0.25 on bivariable analysis were directly forward to be analyzed by multivariable analysis then having P-values < 0.05 is considered as statistically significant.
Result
Out of 422 charts,408 were reviewed with a response rate of 96%, prevalence of procedure-related complications was 18.4%. Being male (AOR = 6.5295%CI:2.41–17.66), diabetes mellites patients (AOR = 2.1795%CI:1.17–4.03), being chronic kidney disease patient (AOR = 3.53, 95%CI:1.37–9.08), having a history of smoking (AOR = 3.69 95%CI:1.77–7.68), radial access (AOR = 0.38,95%CI:0.15–0.99), having ejection fraction of < 30%(AOR = 3.8595%CI:1.47–10.08), from31-40%(AOR = 3.68,95%CI:1.56–8.69) respectively were significantly associated with the outcome of percutaneous coronary intervention.
Conclusion
This study shows that percutaneous coronary intervention in spite of a low mortality rate, complications remain a concern. It is crucial to conduct further studies to identify other keys to determine percutaneous coronary intervention that might be better to conduct a prospective study with better investigation tools.
Multi-objective pathfinder algorithm for multi-objective optimal power flow problem with random renewable energy sources: wind, photovoltaic and tidal
Authors: Li Ning , Zhou Guo , Zhou Yongquan , Deng Wu , Luo Qifang
Published: September 2022

Classical optimal power flow problem is an important optimization problem of power system. Renewable energy can produce electricity with near zero pollution, with the increasing popularity of renewable energy, it becomes more and more urgent to study the optimal power flow problem with renewable energy. In this paper, the standard IEEE30 bus is modified to incorporate renewable energy, and the multi-objective optimal power flow (MOOPF) problem is studied. The MOOPF problem optimization objectives include generation cost, emission, real power loss and voltage deviation (VD). Three renewable energy sources with successful industrial applications including wind energy, solar energy and tidal energy been introduced. Weibull distribution probability, lognormal probability and Gumbel probability are used to calculate the instability and intermittency of wind energy, solar energy and tidal energy, respectively. In order to solve the multi-objective optimal power flow problem with multiple renewable energy sources, a named multi-objective pathfinder algorithm (MOPFA) based on elite dominated set and crowding distance is proposed. Simulation results show that MOPFA can get more evenly distributed Pareto front and provide more diverse solutions. A Compromise solution was selected by the fuzzy decision system. The compromise solution obtained by MOPFA can effectively dispatch the power distribution of the system, and is more inclined to use renewable energy, reducing the power used by thermal power units, which can significantly minimize emissions and other optimization objective. Comparison with the recently published literature also shows that the proposed model can effectively reduce emission and other indicator. In addition, the statistical test results show that MOPFA's multi-objective optimization performance ranks first.
Apolipoprotein C3 facilitates internalization of cationic lipid nanoparticles into terminally differentiated bone marrow-derived mouse mast cells
Authors: Alam Syed Benazir , Wang Feng , Qian Hui , Kulka Marianna
Published: September 2022

Mast cells (MCs), are hematopoetically-derived secretory immune cells that release preformed as well as de novo synthesized inflammatory mediators in response to activation by several stimuli. Based on their role in inflammatory responses, particularly in the lung and skin, MCs provide a convenient and effective target for anti-inflammatory therapeutic strategies. Drug-delivery of lipophilic payloads to MCs can be challenging due to their functionally distinct intracellular structures. In the present study, pH-sensitive cationic lipid-based nanoparticles (LNPs) composed of DODMA, DODAP or DOTAP lipids that encapsulated a GFP or eGFP plasmid were constructed using non-turbulent microfluidic mixing. This approach achieved up to 75-92% encapsulation efficiency. Dynamic light scattering revealed a uniform and homogeneous size distribution of LNPs.To promote cellular internalization, LNPs were complexed with apolipoproteins, amphipathic proteins capable of binding lipids and facilitating their transport in the bloodstream and into cells. Cryo-TEM analysis showed that LNP structure was differentially modified when associated with different types of apolipoproteins. LNP preparations made up of DODMA or DODMA, DODAP and DOTAP lipids were coated with seven apolipoproteins (Apo A1, B, C3, D, E2, E4 and H). Terminally differentiated bone-marrow derived mouse mast cells (BMMCs) were exposed to Apolipoprotein-LNP mixture and internalization was measured using flow cytometry. Out of all the apolipoproteins tested, ApoC3 most efficiently facilitated cellular internalization of the LNP into BMMCs as determined by GFP fluorescence using flow cytometry. These effects were confirmed in a less differentiated but also interleukin-3-dependent model of mouse mast cells, MC/9. ApoC3-LNP enhanced internalization by BMMC in a concentration-dependent manner and this was significantly increased when BMMC were pre-treated with inhibitors of actin polymerization, suggesting a dependence on intracellular shuttling. Activation of peroxisome proliferator-activated receptor gamma (PPAR) decreased ApoC3-LNP internalization and reduced the expression of apolipoprotein E receptor 2 (ApoER2) , suggesting that ApoC3-LNP binding to ApoER2 may be responsible for its enhanced internalization. Altogether, our studies reveal an important role of ApoC3 in facilitating internalization of cationic LNPs into MCs.