bluuebunny/crossref_metadata_2025 huggingface dataset:
Interdisciplinary Connections as the Basis of Systemic Knowledge Among Students of the Faculty of the «General Medicine»
Authors: Chervova Irina Vasilevna , Maltseva Anastasiia Evgenevna
Published: January 2024

The system organization of the human body involves a comprehensive, interdisciplinary consideration of the principles of its functioning. This universal model should be imputed as the basis for teaching biological and medical disciplines in the course of acquiring cognitive skills. The article provides an example of designing a technological map of practical classes in the discipline «Histology, Embryology, Cytology» for more successful mastering of the topic by students, development of their systemic knowledge, which is based on interdisciplinary connections.
Using the career guidance potential of school geography
Authors: Korchagina Elena Valentinovna
Published: January 2024

The article is devoted to the analysis of the possibilities of the educational subject "Geography" in the professional orientation of students. The content of geography covers a variety of topics: nature, population and economy of the Earth, which opens up a wide range of professions for students and provides great opportunities for self-determination. Career guidance in geography lessons should be structured systematically and purposefully in accordance with the work program, the innovations of modern education and taking into account the demands of the labor market of your region. The purpose of the study is to consider the possibility of using geography lessons as a platform for vocational guidance activities of students in order to activate the process of professional self-determination.
THE COUNTRIES OF WESTERN ASIA IN THE PROCESSES OF INTERNATIONAL LABOR MIGRATION: FEATURES OF THE XXI CENTURY
Authors: Shkvarya L. V.
Published: January 2024

The countries of Western Asia simultaneously act as centers of attraction in the processes of international labor migration, and countries, which let their citizens travel abroad to find work (are labor migrants). We analyze the situation in the field of international labor migration in 14 countries of Western Asia, excluding the former republics of the USSR, such as Armenia, Azerbaijan and Georgia, which are now included by international organizations in the group of countries in the region. The situation in the field of labor migration in the region is being updated in connection, firstly, with the growth of the economies of the countries of the Cooperation Council of the Arab States of the Persian Gulf (GCC) and, in general, some stabilization of the socio-economic and political situation in the West Asian region, secondly, with the trends to overcome the restrictions that took place due to the spread of coronavirus infection in the world and in the region, and, thirdly, with the region's attempts to transform the national economy and implement new advanced industries and productions based on innovation and digitalization. It is important to study the experience of the GCC countries in the field of labor migration in order to increase the efficiency and reduce the costs of MMRS in the Russian Federation. The article attempts to analyze the situation in the field of international labor migration in Western Asia, and primarily in the GCC, which actively accept labor from other states of the region and non-regional powers. The author concludes that the region will retain its role as a receiving center for foreign labor in the future on the basis of an adequate policy of the recipient countries. The geography of the countries of origin of immigrants also generally remains unchanged. The research period covers 2000–2022. The author used traditional methods of economic analysis to conduct the research. The sources of statistical information were data from international databases, primarily UNCTAD, as well as regional reports of international organizations.
Bile Acid Application in Cell-Targeting for Molecular Receptors in
Relation to Hearing: A Comprehensive Review
Authors: Ionescu Corina M. , Jones Melissa A. , Wagle Susbin R. , Kovacevic Bozica , Foster Thomas , Mikov Momir , Mooranian Armin , Al-Salami Hani
Published: January 2024

Bile acids play important roles in the human body, and changes in their pool can be
used as markers for various liver pathologies. In addition to their functional effects in modulating
inflammatory responses and cellular survivability, the unconjugated or conjugated, secondary, or
primary nature of bile acids accounts for their various ligand effects.

:

The common hydrophilic bile acids have been used successfully as local treatment to resolve
drug-induced cell damage or to ameliorate hearing loss. From various literature references, bile
acids show concentration and tissue-dependent effects. Some hydrophobic bile acids act as ligands
modulating vitamin D receptors, muscarinic receptors, and calcium-activated potassium channels,
important proteins in the inner ear system.

:

Currently, there are limited resources investigating the therapeutic effects of bile acid on hearing
loss and little to no information on detecting bile acids in the remote ear system, let alone baseline
bile acid levels and their prevalence in healthy and disease conditions. This review presents both
hydrophilic and hydrophobic human bile acids and their tissue-specific effects in modulating cellular
integrity, thus considering the possible effects and extended therapeutic applicability of bile
acids to the inner ear tissue.
Design and Synthesis of 6-amido-3-carboxypyridazine Derivatives as Potent T3SS Inhibitors of Salmonella enterica Serovar Typhimurium
Authors: Li Zhenyu , Liu Zhiyong , Shen Yuemao , Shen Chengwu
Published: January 2024

Background:

Salmonella enterica (S. enterica) serovar Typhimurium, an anaerobic
enteric pathogene, could cause human and animal diseases ranging from mild gastroenteritis to
whole body serious infections.

Objective:

The goal of this paper was to synthesize new 6-amido-3-carboxypyridazine derivatives
with different lengths of side chains with the aim of getting potent antibacterial agents.

Methods:

Synthesized compounds were analyzed by analytical techniques, such as 1H NMR, 13C
NMR spectra, and mass spectrometry. We designed a series of novel 6-amido-3-carboxypyridazines
using FA as the lead compound with the scaffold hopping strategy and their inhibitory
activity against the effectors of type III secretion system (T3SS) using SDS-PAGE and western
blot analysis for two rounds. Also, the preliminary mechanism of action of this series of compounds
on T3SS was performed using real-time qPCR.

Results:

Nine 6-amido-3-carboxypyridazines was synthesized. The inhibitory activities evaluated
showed that compound 2i was the most potent T3SS inhibitor, which demonstrated potent inhibitory
activities on the secretion of the T3SS SPI-1 effectors in a dose-dependent manner. The transcription
of SPI-1 may be affected by compound 2i through the SicA/InvF regulatory pathway.

Conclusion:

The novel synthetic 6-amido-3-carboxypyridazines could act as potent leads for the
development of novel antibacterial agents.
Evaluation of the Quality of Water Samples Purified by Compounding
Pharmacies in Brazil
Authors: Prosperi Ferreira Lucas , Martins Rubatino Marcus Vinicius , de Araújo Magali Benjamin , Bonfilio Rudy
Published: January 2024

Background::

Highly purified water is essential for the production of pharmaceuticals,
directly impacting the quality and safety of the final product.

Methods:

In this work, we studied the physicochemical and microbiological quality of 1477 purified
water samples from 25 compounding pharmacies in Southeast Brazil. To the best of our
knowledge, this is the most comprehensive study on the quality of water purified in Brazil. It was
observed that 47.7% of the samples were purified by reverse osmosis, 39.9% by distillation and
12.4% by deionization. Of the total, 10.63% presented one or more non-compliances. Amongst the
three purification processes, the amount of non-compliance was found to be 8.9% for reverse osmosis,
10.9% for deionization, and 12.4% for distillation.

Results:

It was therefore concluded that reverse osmosis is advantageous. However, even the advantageous
reverse osmosis process showed contamination by viable bacteria, total and faecal coliforms/
E. coli, and Pseudomonas aeruginosa.

Conclusion::

Quantitative data showed that all purification processes significantly reduced the conductivity
and pH values of the input water. However, conductivity values above the limits and several
other non-compliances were found after purification by all processes, which points to the need
for additional studies on improvements in purification processes adopted by compounding pharmacies
in Brazil.
Human Adipose-derived Stem Cells Upregulate IGF-1 and Alleviate Osteoarthritis in a Two-stage Rabbit Osteoarthritis Model
Authors: Wang Juan , Su Shibo , Dong Chuanming , Fan Qiang , Sun Jishu , Liang Siqiang , Qin Zuhuo , Ma Chuqing , Jin Jianfeng , Zhu Hongwen , Jiang Tongmeng , Xu Jun
Published: January 2024

Objective:

In recent times, it has been recognized that mesenchymal stem cells (MSCs)
possess the capability to address osteoarthritis (OA). The objective of this research was to examine
the impact of injecting human adipose-derived stem cells (hADSCs) into a novel rabbit osteoarthritis
model with dual damage.

Methods:

The OA model was established surgically first by medial collateral ligament and anterior
cruciate ligament transection and medial meniscectomy, then by articular cartilage full-thickness
defect. Enhanced Green Fluorescence Protein expressing lentivirus FG12 was used to label
hADSCs, which were then injected into the knee joints. Every single rabbit was sacrificed after 4
and 8 weeks following the surgical procedure. Macroscopic examination, immunohistochemistry
staining, magnetic resonance imaging, qRT-PCR, and ELISA analysis were utilized for the assessments.

Results:

After 4 and 8 weeks, the injection of hADSCs resulted in reduced cartilage loss, minimal
fissures and cracks, and a decrease in the volume of joint effusion and cartilage defect as measured
by MRI. Moreover, the application of ELISA and qRT-PCR techniques revealed that the administration
of hADSCs resulted in an elevation in the IGF-1 concentration.

Conclusions:

Based on our findings, it can be inferred that the transplantation of hADSCs facilitates
the healing of articular cartilage in the osteoarthritis model of rabbits with double damage.
The upregulated IGF-1 may play a crucial part in the process of cartilage repair using hADSCs.
The use of hADSC transplantation could potentially be appropriate for clinical implementation in
managing osteoarthritis.
Dexamethasone Suppresses IL-33-exacerbated Malignant Phenotype of U87MG
Glioblastoma Cells via NF-κB and MAPK Signaling Pathways
Authors: Ai Jie , Weng Yinhua , Jiang Liyan , Liu Chao , Liu Hongbo , Chen Huoying
Published: January 2024

Background:

Interleukin (IL)-33 is highly expressed in glioblastoma (GBM) and promotes tumor
progression. Targeting IL-33 may be an effective strategy for the treatment of GBM. Dexamethasone (DEX) is a
controversial drug routinely used clinically in GBM therapy. Whether DEX has an effect on IL-33 is unknown.
This study aimed to investigate the effect of DEX on IL-33 and the molecular mechanisms involved.

Methods:

U87MG cells were induced by tumor necrosis factor (TNF)-α to express IL-33 and then treated with
DEX. The mRNA levels of IL-33, NF-κB p65, ERK1/2, and p38 were determined by real-time quantitative PCR.
The expression of IL-33, IkBα (a specific inhibitor of NF-κB) and MKP-1 (a negative regulator of MAPK), as
well as the phosphorylation of NF-κB, ERK1/2 and p38 MAPK, were detected by Western blotting. The secretion
of IL-33 was measured by ELISA. The proliferation, migration and invasion of U87MG cells were detected by
CCK8 and transwell assays, respectively.

Results:

DEX significantly reduced TNF-α-induced production of IL-33 in U87MG cells, which was dependent
on inhibiting the activation of the NF-κB, ERK1/2 and p38 MAPK signaling pathways, and was accompanied by
the increased expression of IkBα but not MKP-1. Furthermore, the proliferation, migration and invasion of
U87MG cells exacerbated by IL-33 were suppressed by DEX.

Conclusion:

DEX inhibited the production and tumor-promoting function of IL-33. Whether DEX can benefit
GBM patients remains controversial. Our results suggest that GBM patients with high IL-33 expression may
benefit from DEX treatment and deserve further investigation.
Curcumin- β-Cyclodextrin Molecular Inclusion Complex: A Water-
Soluble Complex in Fast-dissolving Tablets for the Treatment of
Neurodegenerative Disorders
Authors: Mugundhan Sruthi Laakshmi , Balasubramaniyan Purushothaman , Narayanasamy Damodharan , Mohan Mothilal
Published: January 2024

Background:

Orally disintegrating tablets (ODTs) have become an excellent choice for
delivering drugs as their palatability is greatly improved. In this work, β-cyclodextrin has been used
to improve the solubility of curcumin by encapsulating it into the hydrophobic cavity for the treatment
of neurodegenerative disorders.

Objective:

The current study aimed to present the design, formulation, and optimisation of fastdissolving
oral tablets of curcumin- β-cyclodextrin molecular inclusion complex using a 32-factorial
design.

Methods:

The drug-excipient compatibility was studied by FTIR spectroscopy. The inclusion complex
of curcumin-β-cyclodextrin was prepared using solvent casting and confirmed using XRD studies.
Powder blends were evaluated for flow properties. Tablets prepared by direct compression were
evaluated for post-compression parameters. Further, the effect of formulation variables, such as sodium
starch glycolate (X1) and Neusilin® ULF2 (X2), on various responses, including disintegration
time and dissolution at 2 hours, was studied using statistical models.

Results:

Post-compression parameters, i.e., hardness (4.4-5 kg/cm2), thickness (3.82-3.93 mm),
weight variation (±7.5%), friability (< 1%), wetting time (51-85 seconds) and drug content (96.28-
99.32%) were all found to be within the permissible limits and the disintegration time of tablets with
super-disintegrants ranged between 45-58 seconds. The in-vitro dissolution profile of tablets showed
that higher SSG and Neuslin® ULF2 levels promoted drug release. For statistical analysis, the 2FI
model was chosen. Optimised variables for formulation have been determined and validated with the
experimental findings based on the significant desirability factor.

Conclusion:

The current study reveals the validated curcumin-β-cyclodextrin inclusion complex fastdissolving
tablets with SSG and Neusilin® ULF2 to be an ideal choice for effectively treating neurodegenerative
disorders.
Self-Compassion-Based Interventions in Oncology: A Review of Current Practices
Authors: Grégoire Charlotte , Paye Alexandra , Vanhaudenhuyse Audrey
Published: January 2024

Self-compassion consists of an attitude of self-support and self-benevolence. In the general population, increased self-compassion has been associated with well-being and decreased psychopathology. In oncology, higher self-compassion has also been linked with various benefits, such as lower emotional distress, fatigue, body-image disturbances, and sleep difficulties. Self-compassion also seems to foster treatment adherence. Various interventions based on self-compassion have recently been designed and tested in different clinical and non-clinical populations. They are particularly relevant in oncology, as patients are increasingly interested in complementary approaches to help them manage their symptoms and difficulties benevolently and without judgment. In this review, we described various self-compassion-based interventions that have been or will be proposed to patients with cancer, as well as their first results. The main interventions that have been tested are compassion-focused therapy, the combination of self-hypnosis and self-compassion learning, mindful self-compassion training, cognitively-based compassion training, and loving-kindness meditation. Other interventions include a self-compassion-focused writing activity, a mobile self-compassion application, and a self-compassion group therapy focused on the fear of cancer recurrence. Many of these studies were quasi-experimental or protocols. However, existing results tend to suggest the benefits of these interventions to improve different symptoms often endured by patients with cancer. Further research is needed to conduct rigorous studies on these approaches and to determine how and for whom they are efficient.
Combining Digital and Molecular Approaches Using Health and Alternate Data Sources in a Next-Generation Surveillance System for Anticipating Outbreaks of Pandemic Potential (Preprint)
Authors: Ramos Pablo Ivan P , Marcilio Izabel , Bento Ana I , Penna Gerson O , de Oliveira Juliane F , Khouri Ricardo , Andrade Roberto F S , Carreiro Roberto P , Oliveira Vinicius de A , Galvão Luiz Augusto C , Landau Luiz , Barreto Mauricio L , van der Horst Kay , Barral-Netto Manoel ,   ÆSOP Collaborating Teams
Published: January 2024

UNSTRUCTURED

Globally, millions of lives are impacted every year by infectious diseases outbreaks. Comprehensive and innovative surveillance strategies aiming at early alert and timely containment of emerging and reemerging pathogens are a pressing priority. Shortcomings and delays in current pathogen surveillance practices further disturbed informing responses, interventions, and mitigation of recent pandemics, including H1N1 influenza and SARS-CoV-2. We present the design principles of the architecture for an early-alert surveillance system that leverages the vast available data landscape, including syndromic data from primary health care, drug sales, and rumors from the lay media and social media to identify areas with an increased number of cases of respiratory disease. In these potentially affected areas, an intensive and fast sample collection and advanced high-throughput genome sequencing analyses would inform on circulating known or novel pathogens by metagenomics-enabled pathogen characterization. Concurrently, the integration of bioclimatic and socioeconomic data, as well as transportation and mobility network data, into a data analytics platform, coupled with advanced mathematical modeling using artificial intelligence or machine learning, will enable more accurate estimation of outbreak spread risk. Such an approach aims to readily identify and characterize regions in the early stages of an outbreak development, as well as model risk and patterns of spread, informing targeted mitigation and control measures. A fully operational system must integrate diverse and robust data streams to translate data into actionable intelligence and actions, ultimately paving the way toward constructing next-generation surveillance systems.
Impacts of Clinical Decision Support Systems on the Relationship, Communication, and Shared Decision-Making Between Health Care Professionals and Patients: Multistakeholder Interview Study (Preprint)
Authors: Funer Florian , Schneider Diana , Heyen Nils B , Aichinger Heike , Klausen Andrea Diana , Tinnemeyer Sara , Liedtke Wenke , Salloch Sabine , Bratan Tanja
Published: January 2024

BACKGROUND

Clinical decision support systems (CDSSs) are increasingly being introduced into various domains of health care. Little is known so far about the impact of such systems on the health care professional–patient relationship, and there is a lack of agreement about whether and how patients should be informed about the use of CDSSs.

OBJECTIVE

This study aims to explore, in an empirically informed manner, the potential implications for the health care professional–patient relationship and to underline the importance of this relationship when using CDSSs for both patients and future professionals.

METHODS

Using a methodological triangulation, 15 medical students and 12 trainee nurses were interviewed in semistructured interviews and 18 patients were involved in focus groups between April 2021 and April 2022. All participants came from Germany. Three examples of CDSSs covering different areas of health care (ie, surgery, nephrology, and intensive home care) were used as stimuli in the study to identify similarities and differences regarding the use of CDSSs in different fields of application. The interview and focus group transcripts were analyzed using a structured qualitative content analysis.

RESULTS

From the interviews and focus groups analyzed, three topics were identified that interdependently address the interactions between patients and health care professionals: (1) CDSSs and their impact on the roles of and requirements for health care professionals, (2) CDSSs and their impact on the relationship between health care professionals and patients (including communication requirements for shared decision-making), and (3) stakeholders’ expectations for patient education and information about CDSSs and their use.

CONCLUSIONS

The results indicate that using CDSSs could restructure established power and decision-making relationships between (future) health care professionals and patients. In addition, respondents expected that the use of CDSSs would involve more communication, so they anticipated an increased time commitment. The results shed new light on the existing discourse by demonstrating that the anticipated impact of CDSSs on the health care professional–patient relationship appears to stem less from the function of a CDSS and more from its integration in the relationship. Therefore, the anticipated effects on the relationship between health care professionals and patients could be specifically addressed in patient information about the use of CDSSs.
Robodoc: a conversational-AI based app for medical conversations (Preprint)
Authors: Pires Jorge Guerra
Published: January 2024

UNSTRUCTURED

Artificial Intelligence (AI) evolved in trends. Currently, the trend is Conversational Artificial Intelligence (CAI). Those models of AI are focused on text-related tasks, and their commonest applications are chatbots. On this paper, we explore a smart chatbot using the Large Language Models (LLMs) from openAI. I have used a tool called Teachable Machine (TM) from Google to apply transfer learning and create image-based models. I have built two image-based model: for X-ray and for OCT. The model of X-ray is able to detect viral and bacterial pneumonia, whereas the Optical coherence tomography (OCT) model can detect Drusen, Choroidal Neovascularization (CNV) and (Diabetic Macular Edema DME) conditions on the patient9s eyes image. I have also used TensorFlow.js from Google to create a diabetes detection model. All those models are integrated into a chatbot, that according to the message entered by a user, is able to use the models intelligently. Our results show a good integration between the models and the chatbot, with slight deviations from the expected behaviors. For the OCT model, we have also tested a stub function for medical appointments done by the bot, based on how serious is the patient condition. The future of artificial intelligence are public APIs, as I have shown that a complex model can be built, without a complex research infrastructure, and with low costs. Bioinformatics may have gained a new supporter towards more friendly interfaces on bioinformatics.
Changes in the nature of the disease in patients with hypertension and type 2 diabetes mellitus — representatives of the civilian population after a long stay in the combat zone
Authors: Koval S.M. , Penkova M.Yu. , Mysnychenko O.V.
Published: January 2024

Background. In modern conditions, an acute problem in medicine is the issue of a negative impact of war on the course of chronic noncommunicable diseases. The most common of them are hypertension and type 2 diabetes mellitus, which in most cases occur as a comorbidity. To date, a certain amount of work has been carried out to study the influence of war and chronic wartime stress on the development and progression of hypertension. However, the features of the course of hypertension and type 2 diabetes in case of their combination during a long-term stay of patients in combat zones remain unstudied. The purpose: to study changes in the nature of the disease course in patients with hypertension and type 2 diabetes — representatives of the civilian population after a long stay in the combat zone of the Kharkiv region of Ukraine. Materials and methods. Sixty-five patients (civilians) with hypertension and type 2 diabetes (30 men, 35 women) aged from 47 to 64 years were examined. All of them were examined before the start of the war and 4–5 months after staying in the combat zone. Results. In hypertensive patients with type 2 diabetes after their stay in a combat zone, hypertension became more severe (in 89 % of cases, it was uncontrolled, the frequency of hypertensive crisis and resistant hypertension increased significantly). In addition, a significant increase in the frequency of decompensation of carbohydrate metabolism was detected. The examined patients showed a progression of lipid metabolism disorders and the development of new cases of cardiovascular and cerebrovascular diseases. Conclusions. There was a pronounced negative impact of long-term stay of patients with hypertension and type 2 diabetes in a combat zone on the course of both hypertension and diabetes, which was associated with a significant increase in the incidence of cardiovascular and cerebrovascular diseases.
Construções italianas correspondentes à perífrase portuguesa FICAR + particípio passado
Authors: Almeida Andressa Spinosa
Published: January 2024

Partindo de Bertinetto (1986), que define perífrase como construção formada por um verbo modificador que aponta para uma informação gramatical e por um verbo principal que mantém seu significado lexical, entendemos que o objetivo da tradução das perífrases verbais é, principalmente, alcançar equivalência de sentido entre língua fonte e língua alvo. Para nossa análise, em uma abordagem funcional, tomando por referência as pesquisas de Lehmann (2008) e Ribeiro (2016), escolhemos comparar, devido à complexidade do sentido do auxiliar ficar, a construção perifrástica formada por ficar seguido de particípio passado codificando eventos de mudança de estado com construções da língua italiana que carregam um sentido mais aproximado, a fim de testar a hipótese de que o verbo ficar correspondem, em italiano, a variadas construções com verbos diferentes. As construções correspondentes foram coletadas do corpus paralelo OPUS, subcorpus Opentitles 2018 tanto na direção do português para o italiano, como na direção inversa. Os resultados mostraram que o verbo ficar em português corresponde predominantemente a construções perifrásticas com os verbos essere, stare, diventare e rimanere e que o verbo diventare é usado quando a construção com ficar expressa mudança de estado, e os verbos essere, stare e rimanere, quando ficar codifica ideia de permanência, com ou sem processo pressuposto. Tais dados podem ser úteis para os estudos tradutórios e o ensino das línguas portuguesa e italiana como estrangeiras.
THE CONCEPT OF JUSTICE IN THE MODERN LEGAL SYSTEM OF RUSSIA
Authors: Lukovskaya Dzhenevra , Vasilie Ilya , Volkova Svetlana , Ilyin Andrey , Karamyshev Oleg , Kulikova Maria , Malysheva Natalia , Polyakov Andrey , Suyazov Vyacheslav , Timoshina Elena , Yudina Marina
Published: January 2024

The idea of a continuous dialogue between the legislator and its addressees about ‘equity law’ with an emphasis on the moral & legal value of justice as substantive equality (equality in the proper) is suggested as the basis for the concept of justice in Russia today. The fundamental values of law, such as justice, freedom (equality in freedom), human dignity, as they are reflected in the principles of law, thereby acquire a regulatory practical focus, obliging both lawmakers and law enforcers to follow these principles. Justice itself can claim to be a general legal principle. In addition, the article describes the idea of legal justice as the obligation to follow the principles of law. According to this approach, all principles of law are derived from the principle of mutual recognition, including the principle of justice. The principle of mutual legal recognition is the basis for understanding the measure and limits of human responsibility and legal duties, reflecting the principle of solidarity. To assess the applied significance of theoretical studies of justice, the authors turned to the analysis of the acts of the Constitutional Court of the Russian Federation, which through its legal views partially compensates for the lack of a legal constitutional definition of justice. The apparent variability and ambiguity in the language used by the Constitutional Court should not conceal the unified legal nature of the principle of justice. The study of the concept of justice has proven to be particularly relevant in the field of sports: the sport regulators, explicitly or implicitly, are increasingly ignoring the fundamental principles of law. Appeals to justice in sports law illustrates its fragmentation, reduction to equality, and limitation to the purpose of providing procedural guarantees in dispute resolution. Analysis of the current situation in the field of sports suggests that justice should be considered in a comprehensive way: as a material and fundamental basis of normative and legal regulation and law enforcement.
Contemporary Teacher Agency Within the Ecopsychological Paradigm and Its Relationship with Interpersonal Interactions in the Classroom
Authors: Kaptsov Alexandr , Mishakova Galina , Nekrasova Ekaterina
Published: January 2024

The research discusses a parallel-sequential model of agency development stages for teachers of preschool and primary school. The model was successfully tested on students. The authors developed a profile of teacher agency development stages. The most noticeable stages include ‘motivated individual,’ ‘observer,’ ‘master,’ and ‘creator.’ The stage ‘student’ has a little diminished presence, while the another two — ‘apprentice’ and ‘critic’ — are at a very low level. The researchers also outline the interrelationships between agency stages and interpersonal interactions and examine competitive behaviour strategies.
Implementation of Istiqraiyah Method Through Mind Map in Shorof Learning
Authors: Al Farobi Muhammad Al Farobi , Muassomah Muassomah , Muhammad Afiq Aminullah  , Titi Mulyanti  , Mardhiyah Salwa Qozziyatul , Aoh-lam Saardah
Published: January 2024

This study aimed to describe the steps of applying istiqraiyah method through mind maps in Shorof learning and to find out students' interest in applying istiqraiyah method through mind maps in Shorof  learning in Maulana Malik Ibrahim Islamic State University of Malang. This study used mix methods; descriptive qualitative, it describes the steps of applying istiqraiyah method through mind maps in Shorof learning and quantitative, it is to answer students' influence and interest in applying istiqraiyah method through mind maps in Shorof learning. Data collection techniques used interviews, observation, and questionnaires. Quantitative data analysis used the Likert theory to calculate the value of student interest taken from the questionnaire. The results of the study showed that the first step in applying istiqraiyah method through mind maps in Shorof learning is to provide several examples of sentences from al-fi’lul lazim and al-fi’lul muta’adias insights and descriptions, then compiled in a mind map in the form of a definition format, definitions, signs, meanings, wazan, patterns, and ways of changing the usual al-fi’lul lazim to al-fi’lul muta’adi which also begins with various examples. Istiqraiyah method through mind maps in Shorof learning increases the average pre-test and post-test scores of 30.83, which results in a value of 0.73 based on the Gain test, so it is in the high category. As for students' interest in applying istiqraiyah method through mind maps in Shorof learning, it has a presentation index of 73.2% and included in the strong category.
Implementation of an Integrated Curriculum in Improving Arabic Speaking Skills
Authors: Nafisa  , Fitria Cinta  , Maskud  , Abdur Rosyid
Published: January 2024

The aim of this research was to determine the implementation of an integrated curriculum in language learning, especially Mahararah kalam. As  material for improving the curriculum, researchers also discussed learning problems. This research was descriptive qualitative research at Foreign Language Development Institute (LPBA) at Al Yasini Islamic Boarding School, Pasuruan. Data collection techniques were carried out through interview techniques and documentation with related parties. Meanwhile, the data analysis technique used reduction, selection, data collection and data display techniques. The results showed that the LPBA carries an integrated curriculum innovation model. This can be seen from the learning practices carried out. So, at the the Arabic language development institute at Al Yasini and in the language boarding schools, students are accustomed to communicating using Arabic implementing the vocabulary in the teaching materials that have been taught. In addition, the components contained in this learning are also in accordance with the integration of the curriculum used by combining the Arabic language that has been studied with several existing lessons.
History of aviation physiology
Authors: Grebennikov Egor K. , Grebennikova Inna N. , Subotyalova Anna M. , Subotyalov Mikhail A.
Published: January 2024

Relevance. In studying the history of medical and biological disciplines, an important part is the identification of the stages of their formation and development. In this regard, it seems important to make a historical and scientific analytical review of the development of ideas about aviation physiology, covering different stages of the history of science and reflecting the contribution of researchers from different regions. It will be useful for teaching historical and scientific and special disciplines, as well as for researchers involved in the study of aviation physiology. The need to understand how the human body functions in flight arose along with the development of aeronautics. The study is devoted to the analysis of the main stages in the development of aviation physiology. The purpose of the study - to characterize the stages of formation and development of aviation physiology. Research methods. In preparing this publication, articles in publications included in the RSCI, PubMed, and Scopus were mainly used. Preference was given to materials published in the last 15 years. The main results present the stages of development of aviation physiology with a description of the contribution of the main researchers in this field. The achievements of domestic scientists, doctors, physiologists I.M. Sechenov, L.A. Orbeli, G.M. Zarakovsky are analyzed, their scientific priorities in the development of this scientific direction are presented. The process of formation and development of aviation physiology as a direction of biomedical knowledge is presented. Before the advent of aviation (19th century), hypoxia was studied in the study of balloon flights. With the advent of high-speed and maneuverable aircraft, aviation physiology began to study the body’s response to overloads caused by highly maneuverable flights. Conclusion . The development of aviation physiology can be divided into two stages. 1. Pre-aviation, within which the emergence of this area of medico-biological knowledge takes place. 2. Aviation, at this stage scientists have the opportunity to study different multidirectional overloads and their effect on the human body. Currently, aviation physiology is one of the important branches of physiology, aviation and space medicine.
Blood pressure status in patients with metabolic syndrome
Authors: Sorout Jitender , Kacker Sudhanshu , Saboo Neha , Kumar Munesh
Published: January 2024

Relevance. Metabolic syndrome (MetS) is existence of many abnormalities, such as abdominal obesity, hypertension, dyslipidemia, and glucose intolerance. The occurrence of MetS in hypertensive people is linked to poorly managed hypertension. One of the parameters for the diagnosis of the syndrome is the presence of increased blood pressure; nevertheless, research shows that MetS patients are likely to experience hypertension often. Materials and Methods. 300 metabolic subjects were selected from the medicine OPD as study participants based on the joint interim statement’s 2009 definition of the metabolic syndrome. They were divided into three groups (normotensive, pre-hypertensive, and hypertensive) based on blood pressure readings that met the American Heart Association’s (AHA) Asian blood pressure criteria. The following parameters were recorded for data collection: anthropometric (Weight, Height, Body Mass Index Waist Hip Ratio), Blood pressure, biochemical (Fasting blood glucose, Lipid profile parameters). Results and Discussion. According to the resting blood pressure readings, out of 300 metabolic syndrome participants, 37 were normotensive [male (40.54 %); female (59.45 %)], 115 were pre-hypertensive [male (58.26 %); female (41.74 %), and 148 were hypertensive [male (52.7 %); female (47.3 %)]. In several parameters, there was no such significant difference between male and female participants across all groups. However, the levels of blood total cholesterol, triglycerides, and low-density lipoprotein were considerably greater in hypertensive and pre-hypertensive metabolic participants than in normotensive subjects, while the levels of high-density lipoprotein were lower. Conclusion. Study findings suggest, hypertension and pre-hypertension were more prevalent in the group with metabolic syndrome. Additionally, hypertensives have a higher chance of manifesting dyslipidemia.
Experimental models of tumor growth in soft tissue sarcomas
Authors: Tretyakova Mariia S. , Bokova Ustinya A. , Korobeynikova Anastasia A. , Denisov Evgeny V.
Published: January 2024

Soft tissue sarcomas are rare tumors (about 1 % of all malignant neoplasms) and include more than 70 histological subtypes, the pathogenetic features of which remain unclear. This is largely due to both quantity and volume of clinical material and high heterogeneity of the disease. Given the rarity and heterogeneity of each individual subtype of soft tissue sarcoma, there is an urgent need to develop universal model systems to understand the molecular changes that determine tumor biology. Such systems include CDX models (cell line-derived xenograft), created from cell lines, PDX (patient-derived xenograft), obtained from primary tumor/metastasis cells, both a whole fragment of surgical material and from a cell suspension; humanized animals containing various human immune cells, and GEM (genetically engineered mouse) models, which are created through transfection of genetic changes characteristic of different subtypes of soft tissue sarcomas. To create these systems, not only widely available mouse models are used, but also other animals, such as fish (Danio rerio) , rats, pigs, and dogs. Another important goal of using animal models is to screen the effectiveness of modern drugs. To date, treatment of various subtypes of soft tissue sarcomas is based on standard protocols of chemotherapy (doxorubicin, epirubicin, dacarbazine, ifosfamide) and surgical resection. In the case of inoperable forms or late stages of soft tissue sarcomas, animal models are a potential tool in predicting the effectiveness of therapy and personalized selection of treatment regimens. In this regard, studies of the mechanisms of targeted action on specific molecules and the use of humanized animals for the development of new approaches to immunotherapy are of particular relevance. The current review discusses animal model systems of the three most common types of soft tissue sarcomas: liposarcomas, undifferentiated pleomorphic and synovial sarcomas, as well as the use of these models to find new therapeutic solutions. Conclusion. Currently, PDX and GEM models are widely used to identify molecules and signaling pathways involved in the development of sarcomas, identify tumor-initiating cells, and assess the chemoresistance of known drugs and new drugs at the level of the entire tumor ecosystem. However, the key problems of animal models of soft tissue sarcomas remain changes in their composition and phenotype compared to the original tumor, poor survival of surgical material, and lack of cellular immunity in immunocompetent models, high cost, and the length of time it takes to create and maintain the model. A solution to one of the problems may be the use of humanized animals with PDX, which implies the presence in the model of immune, stromal and tumor components that are as close as possible to the human body.
Cerebrovascular diseases epidemiology in the Stavropol region rural residents in the implementation context of the regional program «Fighting mediavascular diseases in the Stavropol region»
Authors: Abramov Alexei Y. , Muravyeva Alla A. , Mikhaylova Julia V. , Sterlikov Sergey A.
Published: January 2024

Relevance. During the implementation of the program for the prevention and treatment of cardiovascular diseases in the Stavropol Territory, measures were taken to prevent hemorrhagic and ischemic strokes, train medical personnel in methods of timely detection of cerebrovascular diseases (CVD), recognition (including through training of the general population) and routing patients with acute cerebrovascular accidents; during a pandemic, opening specialized departments. This organizational experiment required an assessment of its impact on the most medically complex group of the population - rural residents. The aim was to study in dynamics the epidemic situation of CVD among the rural population in the Stavropol Territory in comparison with the Russian Federation. Materials and Methods. Information from official statistical observation forms on the incidence of CVD and mortality from them was studied. Results and Discussion. In the period from 2010 to 2022, there was an increase in the incidence of CVD in the rural population from 464.6 to 1045.1 per 100,000 rural population, which is partly due to the aging of the population, and partly due to improved diagnosis of CVD. The overall incidence of CVD increased from 1275.5 to 3416.1, which suggests an improvement in patient survival. The incidence of strokes of all types tended to decrease, which indicates the effectiveness of the impact on the risk factors for their development. The incidence of unspecified strokes decreased significantly, which led to an increase in the primary incidence of cerebral infarctions (which, however, grew more slowly in the Stavropol Territory than in the Russian Federation as a whole; the coefficients of the regression equations were 2.5 and 4.3, respectively). Between 2015 and 2022. the mortality rates (from 208.4 to 161.1) and mortality (from 5.8 to 2.8) from CVD decreased rapidly (relative to mortality from CVD in the Russian Federation). Conclusion. The proposed set of measures for the prevention and treatment of CVD, including preventive measures, a system of social mobilization, FAST-test, patient routing systems with the delivery of eligible persons to vascular centers within an hour, timely response to new risk factors for the development of CVD, was effective and can be recommended for implementation in similar areas with a high proportion of rural population.
The Quantum Concept of Consciousness: For or Against?
Authors: Knyazev Victor N. , Parshikova Galina V.
Published: January 2024

The study examines a problematic hypothesis of possible approaches to identifying the quantum physical foundations of the functioning of consciousness. The authors proceed from the fact that in modern conditions, not a single science, nor all sciences taken together, gives a final answer to the question of the “mechanism” of the origin of thought. However, this does not mean at all that research in this direction needs to be stopped. The authors express confidence that modern and subsequent research into the “quantum concept of consciousness” will lead to the identification of previously unknown patterns, opening the way to the formation of new principles and approaches. As an example, the corresponding Penrose - Hameroff concept is considered. Quantum mechanics complements the tools of neurobiology and other branches of neuroscience, which together form an interdisciplinary field of knowledge that is dynamically growing and developing. The authors are not apologists for the omnipotence of quantum physics. Quantum correlates of consciousness actually mean that it is not today’s quantum mechanics itself that explains the emergence of mental states, but the fact that in the birth of these states it is essential that in the very process of the formation of neurodynamic impulses in the neurons of the cerebral cortex that generate mental states, there are processes of quantum nature. It should also be recognized that the quantum-molecular level (nanolevel) of processes in the neurons of the brain really exists and it is this that is the source of proto-consciousness. Science strives to move forward, new research programs are emerging within the framework of quantum biology, quantum psychology, quantum information science, which in turn can shed light on the hypothesis of the “quantum concept of consciousness.”
Vaishnavism in Nammalvar’s Poem “Tiruviruttam”
Authors: Moiseev Sergey R.
Published: January 2024

Nammalvar, a Tamil poet who lived in IX-X centuries, is revered as one of the great mystics of India. His four poetic works are equated with the sacred hymns and are part of the ritual worship in the temples of South India. Artistic images of Nammalvar formed the basis of the philosophy of Vishishta-Advaita several centuries later. The poem “Thiruviruttam” is considered as his early work, where he combines the canons of ancient Tamil poetry and his devoted love for Vishnu-Tirumal. The study presents a religious and philosophical interpretation of the poem. The secret of the poem is its dualism: external beauty and sacred meaning. There is a spiritual meaning in symbols of Tamil poetry. Nammalvar takes canons of his predecessors, poets of the Sangam era. However, he fills one with new content. The author compares ancient Tamil poetry and the work of Nammalvar. The plot describes the love between God and the soul. The poet reveals several types of bhakti or devoted love. The description of bhakti subsequently formed the basis for the classification of souls in the philosophy of vishishta-advaita. Bhakti leads to the transition to Vaikuntha or the heaven city. Sri Vaishnavism teachers turned the description of relationship soul-Vishnu into a spiritual practice. The artistic images of Nammalvar are compared with Hindu concepts such as transcendence, darshan, divine grace and moksha. In South India “Thiruviruttam” is considered the Tamil Rig Veda. Poem is performed at home, in the temple, during festive processes. It helps to find the roots of Vaishnavism and understand its poetic origin.