bluuebunny/crossref_metadata_2025 huggingface dataset:
Retrospective Multicenter Study of Elderly Patients With Platinum-Sensitive Relapsed Ovarian Cancer Treated With Trabectedin and Pegylated Liposomal Doxorubicin (Pld) in a Real- World Setting: A Geico Study
Authors: Rubio María Jesús , Manzano Aránzazu , de Sande Luis Miguel , Estévez-García Purificación , Gordon María del Mar , de Prado Diego Soto , de Aranguiz Blanca Hernando Fernández , Guerra-Alia Eva M. , Carbó-Bagué Anna , Romero Ignacio , Corbellas Miguel , González-Haba Alba , Robles-Barraza Carlos E. , Martínez-García Jerónimo , González-Martín Antonio
Published: April 2024

Background
.Trabectedin in combination with pegylated liposomal doxorubicin (PLD) is approved for the treatment of patients with platinum-sensitive relapsed ovarian cancer. Nevertheless, there is currently limited information regarding this treatment in elderly patients with ovarian cancer in a real-world setting.
Methods.
This observational and multicentric study retrospectively evaluated trabectedin plus PLD in a real-world setting treatment of elderly patients diagnosed with platinum-sensitive relapsed ovarian cancer, treated according to the Summary of Product Characteristics (SmPC) from 15 GEICO-associated hospitals. Patients ≥ 70 years old at the time of treatment initiation and platinum-free intervals ≥ 6 months were considered eligible.
Results
Forty-three patients with a median age of 74.0 years were treated between January 1st, 2015, and December 31st, 2019 in 15 Spanish centers. Four patients achieved complete response (9.3%), 14 (32.6%) partial response, and 13 (30.2%) stable disease as the best radiological response. In the analysis of biological overall response according to CA125 serum levels (i.e., Rustin criteria), 14 responded to the treatment (32.6%), 11 responded and normalized (25.6%), three patients stabilized (7.0%) and three progressed (7.0%). Median progression-free survival (PFS) and overall survival (OS) in the study population were 7.7 and 19.5 months, respectively. The most common grade 3/4 adverse events were neutropenia (n = 8, 18.7%) and asthenia (n = 5, 11.6%).
Conclusions.
This analysis demonstrated that trabectedin combined with PLD is a feasible and effective treatment in elderly patients with platinum-sensitive relapsed ovarian cancer, showing an acceptable safety profile, which is crucial in the palliative treatment of these patients.
Evaluation of Perceived Barriers Towards Medical Research among Undergraduate Students
Authors: Emmanuel Mgbedo Nnaemeka , Hussain Aysha , Odzelashvili Inga
Published: April 2024

Background: Research knowledge is crucial in every discipline and profession, especially in healthcare. We aimed to examine the practice, attitude, and perceived barriers to research among medical students, from the University of Georgia.
Methods: This study involved all undergraduate students from the medical, nursing, dentistry, and pharmacy departments of the University of Georgia. 274 students completed this cross-sectional study conducted from February to March 2024. The questionnaire was prepared in Google form which was shared through the University intranet. The data were collected using a self-administered questionnaire and performed statistical analysis using Statistical Package for Social Sciences version 23.0 software.
Results: Most of the participants were international students (94.9%), from the medical department (81.8%) with a mean age of 20.57 (SD D± 2.23). 81.8% never participated in a research project, and 86.9% never attended a research workshop or training. Most of the participants had a positive attitude toward the research study. The commonly perceived barriers were lack of funding, guidance, time, and familiarity with research statistical analysis.
Conclusion: We observed that most of the students had an interest in having a research experience but were faced with difficulties achieving the goal. We suggest that students should be provided with more research opportunities, training, and scholarships that can improve their knowledge and skills in advancing innovation.
Daily versus Twice Daily Nifedipine for Blood Pressure Control in Pregnancy and Postpartum
Authors: Peterson Jessica A. , Band Isabelle C. , Wang Kelly , Bianco Angela
Published: April 2024

Background
Hypertensive disorders of pregnancy (HDP) may be managed with oral anti-hypertensives, however pregnancy induced changes in the hormonal milieu and volume of distribution make it difficult to determine optimal dosing regimens. Nifedipine is a first line therapy for treatment of HDP. The purpose of this study is to compare 60mg daily (QD) of extended released (XR) nifedipine to 30mg twice daily (BID) for blood pressure (BP) control antepartum and postpartum.
Methods
This is a retrospective chart review conducted at the Mount Sinai Health System. Patients admitted from 1/1/2015-4/30/2021, diagnosed with a hypertensive disorder of pregnancy and received nifedipine XR 30mg BID or 60mg QD for intrapartum or postpartum BP control were included. The primary outcome was need for up titration after reaching one of the study doses (30mg BID or 60mg QD), up titration was defined as either an increase in nifedipine dose or addition of another anti-hypertensive. Patients were excluded if they had preexisting renal disease or were already on oral anti-hypertensive medication. In a 1:1 ratio between single daily dosing group and twice daily dosing group, the sample size needed to detect a 20% difference in up-titration rate to achieve 0.80 power is 97 patients per group, for a total of 194 patients. This calculation is based on a Pearson Chi-square test with a significance level of 0.05.
Results
237 patients were included, 139 (59%) received 30 mg BID and 98 (41%) 60 mg QD. There was no statistically significant difference in the need for increase in nifedipine dose or addition of another oral anti-hypertensive agent between those receiving 30mg BID versus 60mg QD (33.8% vs 35.7%; aOR (95% CI): 0.90 (0.50–1.60); p = 0.71). Additionally, there was no difference in need for emergency hypertensive treatment after reaching study dose (p = 0.19) or readmission for BP control between the two groups (p > 0.99).
Conclusions
These findings suggest that BID dosing does not confer better blood pressure control in the antepartum or postpartum periods, thus daily dosing is reasonable and may be preferable for patient convenience and compliance.
Leveraging the power of transformers for guilt detection in text
Authors: Meque Abdul Gafar Manuel , Angel Jason G. , Sidorov Grigori , Gelbukh Alexander
Published: April 2024

In recent years, language models and deep learning techniques have revolutionized natural language processing tasks, including emotion detection. However, the specific emotion of guilt has received limited attention in this field. In this research, we explore the applicability of three transformer-based language models for detecting guilt in text and compare their performance for general emotion detection and guilt detection. Our proposed models greatly outperformed the current state of the art.
Additionally, we analyze the challenges in developing accurate guilt-detection models and evaluate our model's effectiveness in detecting related emotions like \say{shame} through qualitative analysis of results.
A study on Mechincal Properties of Inorganic Binders used in Textile Reinforced Concrete Using Artificial Neural Network
Authors: A Mohan , Madhavi T Ch
Published: April 2024

Textile-reinforced concrete (TRC) is a new and high-performance material made by embedding textile fibers into a matrix. Unlike traditional concrete, TRC doesn't contain coarse aggregate and has a higher proportion of cement paste. In this study, three different types of binders organic, inorganic geopolymer, and epoxy were examined for their impact on compressive and split tensile strengths. These binders were compared by testing mortar cubes (sized 70.6 mm) and cylinders (sized 75 × 150 mm) to see how they affect the properties of TRC. Various types of textile fabrics, including ARG, Basalt, and Hybrid, were experimented with to see how they influence compressive strength and failure modes. The study also examined how the thickness of the textile reinforcement (ranging from 5 to 15 mm) affects TRC performance. The results show that using a hybrid textile fabric with a cementitious binder leads to higher compressive strength. The experimental data underwent verification through the ANN method, where the neural network was trained akin to standard experimental research methodologies. With an impressive accuracy (R2 > 0.99), the ANN model successfully predicted mechanical properties, establishing its reliability in estimating responses and identifying parameters. Additionally, ANN techniques were instrumental in determining the optimal parameters for the study
R.F.L.E.C.T: Enhancing Vietnamese EFL Undergraduates' Pronunciation Proficiency
Authors: Nhat Ton Nu My , Hien Hoang Thi Thu
Published: April 2024

This research employs reflective writing to aid Vietnamese EFL tertiary-level learners in deepening their understanding of English pronunciation by gaining insights into their individual learning experiences. Using an explanatory mixed-methods design, the study involved 94 English-major undergraduates. Quantitative dataset included students’ test scores to assess the learners’ pronunciation ability and the impact of reflective practice on their proficiency in this area. Qualitative dataset consists of the learners’ reflective writings, the thematic analysis of which elucidates the learners’ pronunciation problems, shedding light on their learning journey, specifically their general attitude towards English pronunciation development, the challenges they encounter, the teachers’ instructional approaches, the social and educational context, and the resources, and their voices on how to improve English pronunciation in a foreign context. Results affirm the positive effects of reflective writings on learning outcomes, highlighting students’ active engagement in their educational environment. The study discusses the key values of reflection in higher education using the acronym R.F.L.E.C.T (Realization, Facilitation, Learning, Enhancement, Empowerment, Critical Thinking, andTransformation). While conducted in the context of EFL education in Vietnam, the findings contribute significantly to the international literature on reflective practices, particularly in the teaching and learning of English pronunciation among EFL/ESL learners.
Checking the quality of drinking water in UC Rasheed Wagan, Sindh, Pakistan
Authors: Faraz
Published: April 2024

Drinking water is very important for life. But in the whole world drinking water is not good now for drinking purpose. That’s why this research was done to anlyse the suitability of UC Rasheed Wagan in Larkana. For this purpose 20 samples were taken from different locations and testing was done at the laboratory in technical college Larkana. The water quality parameters such as Ca, Mg, TH, TDS, EC, NO2, NO3, pH, Color and odor was tested for each samples. All standard methods were followed for assessment of water quality. The results revealed that concentration of various physicochemical in Groundwater of UC Rasheed wagan was beyond allowable limit. Only pH was within the limits. Overall, 65% of samples exhibited concentration of Chloride beyond the WHO limit. TH, TDS, EC, Ca, Mg, NO2, NO3, and Zn exceeded in 67%, 88%, 88%, 56%, 29%, 25%, and 18% of groundwater samples. Taste was alos bitter in more 67% of water samples. Overall, the water in UC Rasheed wagan is contaminated to be drunk
MI-BMPI Motor Imagery Brain--Mobile Phone Dataset and Performance Evaluation of Voting Ensembles Utilizing QPDM
Authors: Yilmaz Cagatay Murat , Yilmaz Bahar Hatipoglu , Kose Cemal
Published: April 2024

EEG-based interfaces are an active area of research that has great potential. We therefore focused on classifying motor imaging (MI) tasks from various problem areas. Because of that, we applied MI patterns to voting ensembles differently and constructed voters. They employ quasi-probabilistic distribution models based sub-classifiers made up of different frequency bands and time segments. Much previous work focused on just a few MI tasks for BCIs. To that end, we constructed a new mobile EEG dataset, abbreviated as MI-BMPI, containing two major gestures for mobile phone interfaces, and thus brain-mobile phone interfaces (BMPI) was added to the problem domain. In the research experiments, a consumer market EEG system, the mobile wireless Emotiv EPOC Flex neuroheadset, was used. Experiments were carried out on the BCI Competition IV Dataset 2a and MI-BMPI. On the BCI and BMPI datasets, promising results were obtained in classifying various MI tasks. In conclusion, new solutions were introduced for tougher EEG-based interfaces, which have potential in the classification of MI tasks and the development of EEG-based interfaces. In addition to the average performance improvements, more stable results were achieved for both subject and task variations.
Exploring the Dynamics of Trust in Supplier Relationships: Impacts on Supply Chain Performance
Authors: Gupta Reena
Published: April 2024

This qualitative research explores the intricate dynamics of trust within supplier relationships and its consequential impacts on supply chain performance. In today's globalized and interconnected business landscape, supply chains play a pivotal role in driving organizational success and competitive advantage. Central to the smooth operation of supply chains is the establishment and maintenance of trust-based relationships between buyers and suppliers. Drawing on in-depth interviews and thematic analysis, this study investigates the multifaceted nature of trust within supplier relationships, delving into the factors, mechanisms, challenges, and consequences of trust in real-world business interactions. The findings reveal that trust in supplier relationships is influenced by various factors, including past performance, communication, transparency, and interpersonal relationships. Building and maintaining trust require ongoing efforts from both buyers and suppliers, including performance monitoring, proactive communication, and investment in personal relationships. However, trust is also vulnerable to challenges and threats such as opportunistic behavior, breaches of trust, cultural differences, and external factors. Moreover, the study demonstrates the significant impacts of trust on supply chain performance. Trust is associated with improved operational efficiency, cost management, collaboration, and innovation within supply chains. Conversely, trust deficits can lead to delays, disruptions, and increased costs, undermining the stability and sustainability of supplier relationships. In conclusion, this research contributes to both theoretical knowledge and practical insights in the field of supply chain management. By deepening our understanding of the dynamics of trust in supplier relationships, this study provides valuable guidance for practitioners seeking to build trust-based relationships and enhance supply chain performance in an increasingly complex and uncertain business environment.
Assessing the effectiveness of the Italian Citizenship Income on tackling poverty and inequalities: evidences from Italian municipalities
Authors: Maranzano Paolo , Monturano Gianluca , Tridico Pasquale
Published: April 2024

This paper evaluates the influence of multidimensional phenomena on a guaranteed minimum income policy aimed at supporting the incomes of Italian families in difficulty, namely the Italian Citizenship Income, from 2018 to 2022. We implement a variety of spatial econometric models that relate the number of households benefiting from income support interventions with wealth and poverty indicators, including the average per capita income, share of poverty, and the Gini index. Spatial models handle the strong spatial heterogeneity exhibited by the recipient households by grouping municipal units into homogeneous and spatially-contiguous groups and estimating local relationships. In this way, we are enabled to evaluate how geographical and local factors influence the effectiveness of income support policies. Results show that the presence of multidimensional phenomena significantly influences the requests for income support. However, the sign and the magnitude of the estimated correlation strongly depend on the type of indicator used and by the local structural characteristics. Also, a remarkable augment in term of complexity of the social phenomenon and spatial heterogeneity throughout the period of interest. We estimate positive and statistically significant correlations regarding per capita income and the share of municipal poverty, in particular where both higher socio-economic vulnerability and low-income levels persist. Also, we observe that where both average per capita income and income inequality are high, the policy was unable to reach potential household targets, while in areas characterized by low income but lower income inequality, the income support reached a high number of households.
JEL Classification: H53 , I38 , R12 , C21
Patterns of Dietary Quality, Physical Activity, and Sleep Duration among Cancer Survivors and Caregivers
Authors: Skiba Meghan , Badger Terry A. , Pace Thaddeus WW , Grandner Michael A. , Haynes Patricia L. , Segrin Chris , Fox Rina S.
Published: April 2024

Health behaviors such as fruit and vegetable intake (FVI), moderate-to-vigorous physical activity (MVPA), and sleep duration are associated with cancer-related and general health outcomes. This analysis examined to what degree FVI, MVPA, and sleep co-occur among cancer survivors and informal cancer caregivers and identified sociodemographic and clinical correlates of health behavior engagement. Using data from the Health Information National Trends Survey (HINTS), an exploratory latent profile analysis (LPA) was conducted among a nationally representative sample of those self-reporting a history of cancer or identifying as a cancer caregiver. The LPA model was fit with continuous variables for daily self-reported FVI (servings/d), MPVA (minutes/d) and sleep duration (hours/d). Multinomial logistic regression models were used to predict profile membership based on current age, education, relationship status, income, rurality, body mass index (BMI), other health behaviors, and role (survivor or caregiver). Four health behavior profiles were identified (Least Engaged–Sedentary, Least Engaged–Inactive, Moderately Engaged, and Highly Engaged). The largest profile membership was Least-Engaged Sedentary, capturing 37% of the sample. Profiles were most distinguished by MVPA with the lowest variance in sleep duration. Health behavior profile membership was significantly associated with current age, relationship status, education, income, rurality, alcohol use, self-efficacy, psychological distress, BMI, and cancer type. This study identified that, in a nationally representative sample, cancer survivors and cancer caregivers who reported more FVI also often reported greater MVPA and longer sleep duration. Health behavior profiles and sociodemographic correlates can help identify for whom health behavior interventions may be of greatest benefit.
Ensaios de transversalidade na formação de professores
Authors: Lübeck Marcos
Published: April 2024

O objetivo neste artigo é teorizar sobre atividades educativas implementadas durante mais de uma década numa disciplina de prática/laboratório de ensino, as quais articularam os temas transversais, o teatro e o ensino de matemática, apresentando possibilidades, em retrospectiva e em processo perspectivo, bem como conhecimentos de contextos, cenários, roteiros e peças didáticas elaboradas por licenciandos de um curso de formação de professores de matemática, colocando em evidência educacional a importância da criatividade, da transversalidade, da experiência transdisciplinar, da problematização e da conscientização para ação e para uma educação mais libertadora. A abordagem metodológica desta teorização pauta-se na bricolagem, assim como em teorias e práticas formativas, ensaios, atuações e improvisos, e memórias das aulas de um educador.
Red Propolis: Chemical and Mid-Infrared Spectroscopic Characterization and Classification by Geographic Origin
Authors: de Lima Amanda , Oliveira Thinara , da Silva Marcondes , Ferrão Sibelli , de Almeida Vítor , Santos Leandro
Published: April 2024

In this paper, we report the characterization of Brazilian red propolis from two origins. The commercial value of this product is due to its composition and bioactivity, which depend on geographical factors. Total and individual phenolic, antioxidant, and medium infrared spectroscopic (MIR) characterization of 72 red propolis samples from two origins (Bahia (BA) and Rio Grande do Norte (RN), Brazil) were performed. Samples from RN showed higher concentrations of biomarkers. The BA samples showed higher antioxidant capacity despite having lower concentrations of the red propolis biomarker molecules when compared to the RN samples. The MIRS showed differences regarding the origin. The principal component analysis confirmed the differences, generating well-defined groups. Linear discriminant analysis or discriminant analysis and and partial least squares discriminant analysis showed excellent model performance. The models with MIRS data from raw propolis have a high correct classification rate and require no sample preparation. These findings can affect red propolis production, boosting sustainable extractivism, and changing the reality of small communities.
Flavonoids as Inspiration for the Design and Synthesis of New Antiproliferative, Antiparasitic and Antiviral Compounds: An Account
Authors: Caleffi Guilherme , da Silva Alcides , Daher Netto Chaquip , Domingos Jorge , Salustiano Eduardo , Costa Paulo
Published: April 2024

Modified flavonoids of the sub-group of pterocarpans, 5-carba-pterocarpans, 5-carbapterocarpens, 1-carba-isoflavanones, coumestans, and aurones were synthesized and evaluated as antiproliferative, antileishmanial and antiviral. A new scaffold, called pterocarpanquinone, was discovered and LQB-118, the prototypical scaffold of its series, showed consistent antileishmanial (mice and hamster in vivo) and antineoplastic (respectively, human and mice tumors ex vivo and in vivo) activity. 5-Carpa-pterocarpan LQB-485 is potent towards SF-295 cancer cells (CNS). LQB-262 and LQB-34 are new inhibitors of NB5S RdRp polymerase of hepatitis C virus (HCV) while LQB-314 and LQB-360 demonstrated potent activity and selectivity against HCV replicon reporter cells. LQB-454 and LQB-501 were evaluated for their in vitro anti-proliferative effects against human breast cancer and leukemia cell lines with diverse profiles of drug resistance. In breast cancer they present higher toxicity on multidrug resistant cells (collateral sensitivity). Aurone LQB-814, featuring a “lipophilic phenol” at A-ring”, was a very potent and selective inhibitor of SARS-CoV-2 in Calu-3 cells. Other four aurones bearing EC50 (concentration required to inhibit 50% of cell growth) < 1 were also discovered.
The influence of the acid water of the Banyupait River on the community health in Bantal village, Asembagus, Indonesia
Authors: Yudiantoro Dwi Fitri , Irawan Bambang , Haty Intan Paramita , Pambudi Setia , Tmy Shalva , Suproborini Arum , Bawaningrum Sekar , Ismaya Paramita , Abdurrachman Mirzam , Takashima Isao , Wikaningrum Temmy , Aryanto Noor Cahyo
Published: April 2024

The pH of Mount Ijen crater water is 0-2, resulting in water that is acidic and sulfurous. A fault near the Mount Ijen Crater causes seepage so that acidic water flows into the Banyupait River. Chemical elements and heavy metals originating from the river pollute groundwater and plants. As a result, people around the river consume heavy metals. This research aims to determine the quality of river water and groundwater, as well as determine community factors that are susceptible to dental fluorosis. The methodology used is field mapping and laboratory analysis. For water samples, the Atomic Absorption Spectrophotometer (AAS) method is used. The pH of river water at the research location exceeds the quality standard, namely pH 4-5.5. Meanwhile, groundwater fluorine and sulfate elements exceed quality standards, namely fluorine of 0.6171 mg/L and 0.6870 mg/L, and sulfate ranging from 325-683 mg/L. These two elements cause symptoms of dental fluorosis. Meanwhile, the community factors most susceptible to dental fluorosis are people in the adult age category, and the last level of education is elementary school. This is because the Banyupait River water and groundwater are exposed to fluorine and sulfate water originating from seepage from the Mount Ijen Crater.
Dorobek naukowo-badawczy bp. prof. dr. hab. Andrzeja F. Dziuby
Authors: Kaczmarek Piotr
Published: April 2024

Artykuł prezentuje dorobek naukowo-badawczy bpa prof. dr. hab. Andrzeja F. Dziuby, Biskupa Łowickiego. Po przedstawieniu krótkiej noty biograficznej, skupiającej się głów- nie na drodze naukowej bpa Dziuby, zaprezentowano liczbowe ujęcie jego dorobku. W stosownych wypisach wyszczególniono liczbę i charakter publikacji, a także tytuły wybranych periodyków naukowych, z którymi bp Dziuba współpracował. Artykuł ma charakter biblio- graficzny i jest oparty na bogatym dorobku naukowo-badawczym bpa A.F. Dziuby, który obejmuje ponad 3500 pozycji.
Wspólnota diecezjalna i parafialna w centrum posługi biskupa łowickiego Andrzeja F. Dziuby
Authors: Swędrowski Jerzy
Published: April 2024

Kościół w języku chrześcijańskim oznacza zgromadzenie liturgiczne, a także wspólnotę lokalną lub całą powszechną wspólnotę wierzących. Kościół żyje Słowem i Ciałem Chrystusa, sam stając się w ten sposób Jego Ciałem (por. KKK 752). Kościół jako pierwszy podtrzymuje wiarę i ją wyznaje. To dzięki Kościołowi otrzymujemy wiarę i nowe życie w Chrystusie. Życie w Kościele jest realizacją woli Ojca, który powołuje ludzi w swoim Synu Jezusie Chrystusie. Kościół święty, powszechny i apostolski wyraża swój dynamizm we wspólnotach partykularnych, czyli w diecezjach i parafiach, zaś następcy Apostołów stają się znakiem jedności. Każda diecezja i parafie ją tworzące ukazują nie tylko historię, ale przede wszystkim życie tych, którzy w sposób sakramentalny weszli we wspólnotę i ją budują. Tutaj objawia się charakter różnorodnych posług i odpowiedzialności, które mają działać na sposób służebny, jak również na sposób kolegialny. Wspólnota wierzących objawia swoją żywotność poprzez zaangażowanie pasterzy i rozwój Ludu pielgrzymującego, który odnajduje swoje ewangeliczne powinności. Misja nauczania, uświęcania i rządzenia wpisuje się w sposób integralny w jedność z powołaniem świeckich, którzy uczestniczą w misji kapłańskiej, prorockiej i królewskiej Chrystusa. Droga pasterzy i wiernych w Kościele partykularnym jest odpowiedzią na dar powołania do wspólnoty i budowania królestwa Bożego.
Kościół i świat w dobie obrad soborowych
Authors: Skibiński Paweł
Published: April 2024

Kościół katolicki w 1960 roku przeżywał okres umacniania swego znaczenia w świecie zachodnim, bowiem postawa Kościoła podczas II wojny światowej z jednej strony, a rozwój organizacyjny środowisk katolickich z drugiej strony zapewniły mu znaczny kapitał społeczny. Jednocześnie jednak Kościół zmagał się z postępującymi zjawiskami laicyzacji i sekularyzacji: dobrowolnej propagowanej przez zwolenników liberalizmu i permisywizmu, dążących do ograniczenia wpływów religii na rzeczywistość, a także przymusowej realizowanej przez państwa i ruchy komunistyczne. Ten drugi prąd wiązał się z falą prześladowań katolików. Jednocześnie Kościół stał wobec wyzwania wewnętrznego związanego z prądami teologicznymi „neomodernizmu”. Był to problem odpowiedzi myśli katolickiej na wyzwanie modernizacji, związanej z gwałtownym rozwojem nauki i postępem technologicznym oraz z rozwojem myśli współczesnej m.in. z filozofią marksistowską. Będzie to owocować różnymi formami tzw. dialogu katolicko-marksistowskiego. 

Kolejnym wyzwaniem dla Kościoła w latach 60. XX wieku będzie rewolucja seksualna, z towarzyszącym jej rozpowszechnieniem antykoncepcji, pornografii i przyzwoleniem na nieograniczoną swobodę seksualną. Zjawisko to postawiło przed Kościołem szereg nowych pytań etycznych i duszpasterskich. 

Wreszcie przemiany geopolityczne związane z dekolonizacją postawiły przed Kościołem pytanie o inkulturację katolicyzmu w kulturach tych regionów świata.
Troska prymasa Stefana Wyszyńskiego o Polonię w świetle zapisków "Pro memoria" z okresu obrad Soboru Watykańskiego II
Authors: Czekalski Ryszard
Published: April 2024

Sprawowanie duchowej opieki nad Polonią historycznie przynależało do prerogatyw prymasa Polski kard. S. Wyszyńskiego, który poczuwał się do tej roli, jednak wskutek sytuacji politycznej w kraju nie zawsze miał możliwość w pełni się z niej wywiązywać. Dogodną okazję do spotkań ze środowiskiem polonijnym dawały mu wyjazdy na cztery sesje obrad Soboru Watykańskiego II (1962-1965). Ich ślady zachowały się w dzienniku Pro memoria prowadzonym przez księdza prymasa. W ich świetle można dostrzec jego otwartość na spotkania z różnymi grupami osób (prywatnych, duszpasterzy polonijnych czy przedstawicieli organizacji polonijnych zarówno o charakterze kościelnym, jak i świeckim). Służyły one m.in. pogłębianiu więzi Polonii z ojczyzną, inicjowaniu przygotowań do obchodów Millenium Chrztu Polski oraz rozwijaniu działalności wydawniczej na potrzeby Kościoła w Polsce oraz Polaków mieszkających za granicą.
Działalność medialna prymasa Stefana Wyszyńskiego – przemiany i rozwój
Authors: Boguszewski Mariusz
Published: April 2024

Działalność medialna kard. Stefana Wyszyńskiego, prymasa Polski była aktywna w trzech ważnych okresach w najnowszej historii Polski, a jednocześnie w najnowszej historii Kościoła katolickiego. Był to czas dwudziestolecia międzywojennego, kształtowania się ustroju PRL-u, a także wydarzeń Soboru Watykańskiego II. W każdym z tych okresów Kościół starał się skutecznie wykorzystywać rolę mediów w promowaniu swojej misji w społeczeństwie. Szczególnie interesujący w omawianym temacie jest drugi chronologicznie i zarazem najdłuższy z wymienionych okresów, czyli czas zmagań Kościoła katolickiego z antyreligijnym przesłaniem władz komunistycznych w Polsce. Prymas Wyszyński wielokrotnie manifestował w mediach wagę idei wolności, sprzeciwiając się jej ograniczaniu przez władzę ludową.
"Duch pracy ludzkiej" Stefana Wyszyńskiego – narodziny teologii pracy
Authors: Chrabka Justyna
Published: April 2024

Stefan Wyszyński jako młody kapłan obserwował życie robotników włocławskich – uczył ich katolickiej nauki społecznej, przedstawiając ją jako remedium na wykorzystywanie przez kapitalistów i komunistów. Był blisko człowieka pracującego i znał jego bolączki. To doświadczenie, poparte w czasie podróży naukowej obserwacją życia robotników na Zachodzie Europy, w trakcie którego przyglądał się instytucjom zajmującym się ludźmi pracy, zaowocowało powojenną publikacją książki Duch pracy ludzkiej. Książka zawierała dojrzałe przemyślenia dotyczące teoretycznej i chrześcijańskiej koncepcji pracy i pracownika. Dawała odpowiedzi na pytania o to, jak efektywnie pracować i jak rozwijać się zawodowo i duchowo. Duch pracy ludzkiej stał się podstawą do późniejszego nauczania kard. Wyszyńskiego, który wielokrotnie wracał do myśli zawartych w tej książce, moralnie kształtując kolejne pokolenia. Okazała się ona humanistyczną i jednocześnie chrześcijańską pozycją, która może być czytana również dziś.
Prymasowskie pełnomocnictwa z 1958 roku dla Grodzieńszczyzny
Authors: Grajewski Andrzej
Published: April 2024

Obrona praw ludzi wierzących na Wschodzie była ważnym imperatywem posługi prymasa Polski kard. Stefana Wyszyńskiego. Jego aktywność na tym polu była możliwa dzięki nadzwyczajnym pełnomocnictwom, jakie otrzymywał od kolejnych papieży. Nie znamy jednak szczegółów wykonywania przez kard. Wyszyńskiego jego misji na Wschodzie. W tym kontekście istotne znaczenie ma notatka sporządzona przez ks. Michała Aronowicza z Grodna na Białorusi, która opisuje okoliczności przekazania mu specjalnych pełnomocnictw prymasowskich w 1958 roku. Dokument znajduje się w archiwum Polskiego Papieskiego Instytut Kościelny w Rzymie.
Ksiądz Antoni Lipowski (1839-1911), duszpasterz lat dziecięcych prymasa Stefana Wyszyńskiego
Authors: Sukiennik Edgar
Published: April 2024

Autor podjął próbę przybliżenia życiorysu księdza kanonika Antoniego Lipowskiego, który w historiografii kościelnej występuje przede wszystkim jako proboszcz parafii Przemienienia Pańskiego w Zuzeli oraz szafarz sakramentu chrztu Stefana Wyszyńskiego – późniejszego arcybiskupa metropolity gnieźnieńskiego i warszawskiego, prymasa Polski. Tymczasem w życiu pracowitego duszpasterza udało się ustalić wiele innych epizodów, które rzucają więcej światła na jego dzieciństwo, środowisko rodzinne oraz posługę w kilku parafiach.
Formação de Profissionais de Enfermagem em Libras Enquanto Instrumento dos Princípios de Universalidade, Integralidade e Equidade do Sus
Authors: Santos Thayna Carvalho dos , Borges Renata da Costa Santos , Pereira Raphael Dias de Mello
Published: April 2024

O Sistema Único de Saúde (SUS) é norteado a partir de 03 princípios: a universalidade, integralidade e equidade. Dito isto, essa pesquisa sustenta a hipótese de existirem barreiras no acesso de pessoas com deficiência auditiva ao SUS proporcionadas pela linguagem, que prejudica todos os níveis de prevenção de saúde, destacando-se a prevenção primária. E que, portanto, a capacitação da enfermagem em LIBRAS é primordial para estabelecimento dos princípios do SUS, uma vez que a classe profissional tem papel de destaque na Atenção Básica de Saúde. Sendo assim, este artigo tem objetivo de revisar a literatura científica que trata sobre a formação em LIBRAS dos profissionais de enfermagem da Atenção Primária de Saúde e seus impactos na assistência oferecida aos pacientes surdos sob a luz dos princípios de integralidade, universalidade e equidade do SUS e das metas de Segurança do Paciente. A metodologia escolhida foi a revisão integrativa de literatura. Tendo como fonte de pesquisa as seguintes plataformas de periódicos acadêmicos: Biblioteca Virtual de Saúde (BVS) e Scielo. Como resultado, reuniu 08 artigos que tratavam sobre o acesso dos surdos à saúde e as barreiras enfrentadas relacionadas ao desconhecimento dos profissionais de enfermagem a LIBRAS, bem como, demonstrou estratégias utilizadas pelos enfermeiros para promover a comunicação com esses clientes. Por fim, todos os estudos reunidos evocaram sobre o impacto positivo da comunicação efetiva entre profissionais de enfermagem e o paciente tanto no acesso ao serviço de saúde, quanto à segurança na assistência prestada.
Palavras-Chave: Surdez; Pessoas com Deficiência Auditiva; Atenção Primária à Saúde; Línguas de Sinais.
Percepção da equipe de enfermagem sobre impactos da pandemia covid-19 sobre o trabalho na CME
Authors: Pereira Thamyres de Medeiros , Pires Ariane da Silva , Batista Deyse Conceição Santoro , Souza Rogério Marques de , Sá Fernanda Corrêa de , Sampaio Carlos Eduardo Peres
Published: April 2024

A COVID-19 é uma emergência de saúde pública, pois já causou infecção em 37.994.356 milhões de pessoas e 706.986 mil óbitos no Brasil, atualizados em novembro de 2023. Objetivos foram identificar a percepção da equipe de enfermagem sobre os desafios e as adequações adotadas na central de material e esterilização em meio à pandemia da COVID-19, assim como analisar os procedimentos preventivos implementados. O projeto de pesquisa foi aprovado pelo Comitê de Ética do Hospital onde foi realizado, com parecer de nº 4.502.948 e número de CAAE 40783820.3.0000.5282. Foi desenvolvido um estudo qualitativo realizado com 28 profissionais de enfermagem. A coleta de dados ocorreu por meio de entrevista semiestruturada. Os dados foram analisados mediante transcrição e análise de conteúdo.  A partir da análise de conteúdo foram identificadas duas categorias: (1) Percepção da equipe de enfermagem sobre os desafios e mudanças frente a pandemia pela COVID-19 e (2) aspectos de biossegurança implementados para prevenção da COVID-19.  O estudo permitiu descrever a percepção da equipe de enfermagem da Central de Material e Esterilização sobre os desafios e mudanças e medidas preventivas no setor acerca do contexto da pandemia da COVID-19, ressaltando a importância e ofertando destaque aos equipamentos de proteção, ainda nesse sentindo fundamentando a contribuição do profissional enfermeiro em empoderar a equipe com ações educativas como capacitações. Ao final do estudo podemos concluir que os objetivos do estudo foram atingidos, mas a temática sugere novas pesquisas que venham contribuir sob novas perspectivas no âmbito das centrais de material e esterilização.
Palavras-Chave: Esterilização; Equipe de Enfermagem; Infecções por Coronavirus.
Educação permanente na reorganização do processo de trabalho de uma emergência hospitalar: um diagnóstico situacional
Authors: Barbosa Gabryella Vencionek , Cortez Elaine Antunes , Valente Geilsa Soraia Cavalcanti , Dutra Virgínia Faria Damásio , Messias Claudia Maria , Almeida Yasmin Saba de
Published: April 2024

A emergência hospitalar desempenha um papel crucial na redução de óbitos e possíveis complicações advindas de situações potencialmente críticas. Entretanto, é possível observar diversas fragilidades teórico-práticas por parte dos trabalhadores da unidade de emergência, de modo a comprometer a assistência ao paciente. Assim, este estudo visa realizar um diagnóstico situacional com a equipe de emergência sobre as ações educativas necessárias para a melhoria do processo de trabalho. Trata-se de uma pesquisa descritiva e exploratória, com abordagem metodológica qualitativa, estruturada na primeira fase da Pesquisa Convergente Assistencial. Os participantes do estudo foram os trabalhadores do setor de emergência do Hospital Geral de Arraial do Cabo. Para a coleta de dados foi foram realizadas entrevistas individuais com questões semiestruturadas, que foram analisadas a partir da análise de conteúdo Bardin. A análise de conteúdo gerou duas categorias e duas subcategorias. Observou-se que os profissionais de saúde têm dificuldade em diferenciar a Educação Permanente da Educação Continuada. Os profissionais sugeriram como estratégias a realização de ações educativas frequentes, em grupos, alinhadas com as demandas profissionais, além de considerarem a inclusão e comunicação multiprofissional, utilizando-se das tecnologias relacionais para o fortalecimento do processo educativo. O diagnóstico situacional demostrou a percepção dos trabalhadores sobre a ausência de ações educativas, o significado da Educação Permanente para eles, bem como os estimulou a refletir sobre estratégias para inserção da prática educativa no setor, trazendo visibilidade para as relações multiprofissionais e relacionais, a necessidade de escuta e diálogo entre os trabalhadores e gestores, e a valorização do esforço coletivo.
Palavras-Chave: Serviços Médicos de Emergência; Educação Permanente; Capacitação em Serviço; Administração de Serviços de Saúde.
Synthesis of Rupestonic Acid L-Ephedrine Derivatives with Preliminary In
vitro Anti-influenza Viral Activity
Authors: Yong Jianping , Lu Canzhong
Published: April 2024

Background:

Influenza virus is a kind of RNA virus. Nowadays, the high incidence of influenza
and the morbidity and mortality of epidemic influenza are substantial. It has been reported that one hundred
million people in the world are infected with influenza viruses, and two hundred and fifty thousand to five hundred
thousand people die from the flu per year. In 2021, the number of infected persons in China was reported
to be 654,700, and 0.07% of the infected persons died. The flu has caused a serious threat to human survival.
Although several drugs, such as Zanamivir, Oseltamivir, Peramivir, and Laninamivir, have been used in clinics
for the treatment of the influenza virus, there are some shortcomings of these drugs. The strain of influenza
H5N1 (avian influenza) has been found to resist the effective drug Oseltamivir. Thus, there is an urgent demand
to discover new influenza virus inhibitors to overcome the emergence of influenza antigens.

Aims:

This study aimed to develop new influenza virus inhibitors based on the rupestonic acid parent core.

Objective:

The rupestonic acid L-ephedrine ester (A) and rupestonic acid L-ephedrine complex (B) were synthesized
in this work for the development of influenza virus inhibitors.

Methods:

The target compounds were synthesized using rupestonic acid and L-ephedrine as starting materials.
Their structures were characterized by 1H NMR and 13C NMR, and the purity was determined by HPLC. Then,
their preliminary in vitro influenza activity was evaluated using Oseltamivir as a reference drug.

Results:

The results showed that the synthesized rupestonic acid L-ephedrine derivatives A and B were more
potent influenza virus inhibitors against the strains of A/PR/8/34 (H1N1) and A/FM/1/47 (H1N1) with the IC50
values of 51.0, 51.0 μM and 441.0, 441.0 μM, respectively, than that of rupestonic acid. By comparing the IC50
of compounds A and B, compound A can be regarded as a very promising lead compound for the development
of influenza virus inhibitors.

Conclusion:

The rupestonic acid L-ephedrine ester (A) and rupestonic acid L-ephedrine complex (B) were synthesized
and characterized using 1H NMR and 13C NMR. Moreover, their purity was determined by HPLC.
Both compounds A and B exhibited more potent activities against the strains of A/PR/8/34 (H1N1) and
A/FM/1/47 (H1N1) than rupestonic acid. Compound A can be regarded as a very promising lead compound for
the development of influenza virus inhibitors. Based on these results, more rupestonic acid derivatives will be
designed and synthesized in the future for the development of influenza virus inhibitors.
Determination of Ketamine and Palmatine in Rat Plasma by
UHPLC-MS/MS and their Pharmacokinetic Interaction
Authors: Huang Xueli , Ma Yizhe , Wang Ziyue , Wang Wanhang , Wen Congcong , Wang Xianqin , Zhang Meiling
Published: April 2024

Objective::

Ketamine, commonly known as “K-powder,” is increasingly being abused
as a “prom drug.” Palmatine, a typical isoquinoline alkaloid, is mainly found in the roots and
stems of natural Chinese herbal medicine plants such as Phellodendron chinense, Coptis chinensis,
Sankezhen and Nantianzhu. Herein, we aim to establish a UHPLC-MS/MS method to determine
ketamine and palmatine concentrations in rat plasma and investigate the pharmacokinetic interaction
of ketamine and palmatine.

Methods::

Three groups of eighteen rats each were assigned to ketamine, palmatine, ketamine and
palmatine. The pharmacokinetic interaction between ketamine and palmatine was demonstrated using
UHPLC-MS/MS.

Results::

When ketamine was combined with palmatine, the mean residence time (MRT) was significantly
different from that of the ketamine group. MRT decreased after combined use. The interaction
showed that palmatine can influence the mean residence time of ketamine; no significant
differences were observed for other pharmacokinetic parameters between the ketamine or palmatine
group and the ketamine-palmatine group.

Conclusion::

Palmatine may influence the mean residence time of ketamine.
Tribological and Mechanical Properties of Graphene Nano Platelets
(GNP)-Reinforced Aluminium 7075 Nano Composites
Authors: Chaurasia Rahul , Sarangi Saroj Kumar
Published: April 2024

Background::

The present need for manufacturing industries is the creation of a new
class of engineered materials with high specific properties. In this regard, nanocomposite materials
have shown promising results compared to monolithic materials. Recent patents also show high
mechanical and tribological properties.

Objective::

The tribological and mechanical properties of graphene nanoplatelets (GNP)-reinforced
aluminium 7075 nanocomposites are reported in this article with the objective of finding optimum
properties.

Methods::

The nanocomposites were successfully produced with the stir casting technique, a liquid
metallurgy route with varying weight percentages of reinforcement composition of 0.5%, 1%, and
2%.

Results::

The result showed an improvement in ultimate tensile strength of 69.5% and microhardness
of 76.67% in contrast to the base alloy when it was cast. The wear rate was dropped significantly
by 43% and 40% in 10N and 20N loading conditions with respect to as-cast conditions. Further,
a decrease in the average coefficient of friction was observed from 0.680 to 0.565.

Conclusion::

Graphene nanoplatelets came out as excellent reinforcement in the aluminium 7075
alloy, as they showed an impact on improved properties. The decreasing wear rate and coefficient
of friction showed their self-lubricating nature. Additionally, X-ray diffraction (XRD) results and
optical microstructure were also discussed.
Assessing Chicken Rendang in Padang: Quality, Nutrition, and Sensory Analysis
Authors: Novia Deni , Yuherman  , Winda Sartika  , Rini Rustini
Published: April 2024

Chicken rendang is loved by children and adults alike but is still often found in restaurants in Padang City. As a representative of the Minang Region, the city of Padang is very representative of sampling chicken rendang because each rendang has a different process and taste. This research examined the quality, nutritional value, and taste of chicken rendang sold in Padang City. The method used in this research was a survey method with random sampling (purposive sampling), and then laboratory analysis was carried out. Data processing used a 9x2 randomized block design (nine samples and two groups), with samples being places where chicken rendang was taken from 8 restaurants in the city of Padang and one chicken rendang sold commercially (packing) as a control, while quality test without using controls. The parameters observed were quality (FFA, TBA, and cholesterol levels), nutritional value (moisture content, protein content, fat content, ash content), and sensory analysis (color, aroma, texture, and taste of 30 untrained panelists) of chicken rendang. Sample G had the highest nutritional value but was lower than the sensory analysis. On the other hand, the sample I had the highest sensory assessment and high-fat content. Sample D was the best sample regarding quality, nutritional value, and sensory with FFA 0.800%, TBA 0.021 mg malonaldehyde/kg, cholesterol levels 44.35 mg/dl), nutritional value (moisture content 45.03%, protein content 14.48%, fat content 15.44%, ash content 2.80%), and sensory analysis neutral.
Kinetics of Deterioration of the Quality of Purebred Chicken Egg Meal During Storage
Authors: Rotinsulu Merri Diana , Sjaloom Ester Sakul
Published: April 2024

The research objective to determine quality of purebred chicken egg meal deteriorates during storage. The research method used experimental method, counting was a completely randomized design consisting of 5 treatments and 4 replications. As a treatment, the storage time for purebred chicken egg flour at room temperature is formulated as follows T0 (0 days), T1 (10 days), T2 (20 days), T3 (30 days) and T4 (40 days). The variables observed were water content, pH and total microbes. The results of analysis of variance showed that storage time at room temperature had a highly significant different effect (P<0.01) on the water content, pH and total microbes of purebred chicken egg flour. The results of the orthogonal polynomial test show that storage time at room temperature has a highly different linear effect on water content obtained by the equation Y=6.561+0.0177X, linear and quadratic on pH obtained by the equation Y=7.64+0.0095X+0.00015X2   and total microbial colonies of purebred chicken egg flour obtained by the equation Y=2686-0.0172X+0.0006X2. It can be concluded that the kinetics of deterioration in the quality of purebred chicken egg flour occurs 0.25% increase for water content and 0.25 increase for pH and 0.24 log cfu/g increase in the number of bacterial colonies during storage.