bluuebunny/crossref_metadata_2025 huggingface dataset:
Faktor - faktor Penyebab Rendahnya Minat Melanjutkan ke Perguruan Tinggi di SMK Miftahul Ulum Cimerak
Authors: Nurmalasari Neneng , Hidayat Taopik , Rosadi Imron , Yunita Rika , Holisoh Elis
Published: March 2024

This research is entitled, "Factors Causing Low Interest in Continuing Education to Higher Education". The purpose of this research is to examine what factors cause low interest in continuing education to tertiary institutions (universities) at SMK Miftahul Ulum Cimerak. This research uses qualitative research with descriptive type, collection technique with triagulation (combined), data analysis is inductive/qualitative, and taking informants by purposive sampling with a total of 44 informants. The data source for this research was a questionnaire filled in by students at SMK Miftahul Ulum Cimerak. The results of this study are (1) the internal factors that cause low interest in continuing their education to tertiary institutions are the lack of motivation or desire to go to college and the desire to find work independently. (2) External factors that cause low interest in continuing education to tertiary institutions are economic limitations or expensive tuition fees and social environmental factors.
Data Base Manajemen Sistem dalam Inventaris Sarana Prasarana di SMK Pasundan Cijulang
Authors: Safitri Bela , Dheca Dheca , Nuryadin Nuryadin
Published: March 2024

The purpose of this study is to analyze the use of database management systems in inventorying infrastructure. This research method uses qualitative methods with data collection techniques of interviews, observation and documentation. The data analysis technique used the Miles and Huberman technique and tested the validity using the triangulation technique. The results of this study, namely based on observation results, it can be seen that 1) the database management system at SMK Pasundan Cijulangis only carried out in managing the inventory of infrastructure facilities 2) the process of inventorying infrastructure facilities, namely in the process of inventorying goods and the process of borrowing goods. 3) The use of inventory databases in the infrastructure process at SMK Pasundan Cijulang was carried out based on Microsoft Excel.
Hubungan Manajemen Perpustakaan dan Peran Guru Terhadap Minat Baca Siswa di MAN 1 Pangandaran
Authors: Merisa Nova , Ilmi Irpan , Supriadi Predi , Sugiarti Anza
Published: March 2024

A high interest in reading will affect a person's skills. Each skill is interrelated with each other and is related to the processes that underlie language skills. Seeing the importance of reading interest, efforts are needed to foster reading interest in a person. Therefore, the school library must be utilized as much as possible as an information resource center and a center for fun educational recreation facilities for its users, especially students, so that it is hoped that the school library can foster students' interest and love of reading. The purpose of this study is how library management, how the role of teachers on reading interest, how student reading interest, is there a relationship between library management and student reading interest, is there a relationship between the role of teachers on student reading interest, is there a relationship between library management and the role of teachers on student reading interest. This study only focuses on the relationship between library management and the role of teachers on student reading interest. The type of approach used is qualitative method with naturalistic research method because the research is conducted in natural conditions (natural environment). The relationship between the library and the role of the teacher is quite good, while the role of the teacher in improving student reading is very instrumental. Therefore, all teachers must understand the role of what it takes to improve student skills at MAN 1 Pangandaran. This research is expected to contribute to related parties such as principals, teachers, committee administrators to add insight or knowledge about the importance of library management and teacher motivation in fostering students' interest in reading.
Implementasi Pendidikan Ekologi Berbasis Sekolah Lapangan di SMK Bakti Karya Parigi
Authors: Julaeha Siti , Marliani Rina , Agustini Aini Ali , Samsudin Samsudin
Published: March 2024

A lot of empty land that is left without any plants planted, can be an ideal place for the growth of weeds. At SMK Bakti Karya Parigi, vacant land is used as an object of field school-based ecological learning. The background of this research is to create innovation in conducting field schools. Field school-based Ecology Education is one of the learning methods at Bakti Karya Parigi Vocational School which aimsto provide a more practical and hands-on learning experience in the workplace. In this research, we aim to evaluate the implementation of Field School-Based Ecological Education at SMK Bakti Karya Parigi. This research method uses a qualitative approach that focuses on in-depth observation. Therefore, the use of qualitative methods in research can produce a more comprehensive study of a phenomenon. This research is intended to find out how to implement ecological understanding by conducting field schools. This research resulted in the implementation of field school-based management of ecological learning management that uses management functions in it
Faktor Pendukung dan Penghambat Manajemen Kelas di TK Harapan Sindangsari
Authors: Julian Panisa Dwi , Ditha Fitria Elsa , Maulidah Indah , Widayanti Widayanti , Nurajijah Ayi , Nuroniah Enung , Banyutresna Sulastri
Published: March 2024

The education is very important in improving quality, because of that education improvements are carried out related to improving the teaching and learning process. Therefore, good classroom management is needed so that teaching and learning objectives canbe achieved. In classroom management, the teacher should pay attention to and create a classroom atmosphere so that it remains safe, comfortable and conducive. There are supporting and inhibiting factors in classroom management. This study aims to find out how the supporting and inhibiting factors of classroom management at Harapan Sindangsari Kindergarten are. This study used a qualitative approach with a descriptive research type. The techniques used in data collection are observation, interviews and document techniques. Data analysis uses inductive data analysis. The results of the study show that class management at Harapan Sindangsari Kindergarten has been going well but not optimally. Factors supporting classroom management come from facilities, teachers, principals, parents and students, inhibiting factors are challenges faced by teachers, how to handle children who need more attention, how to handle situations when many children are fussy, obstacles involving parents in the educational process of children in the kindergarten class
Konsep Pendidikan Ahlak (Takhallaqu Bi Akhlaqillah) Sebagai Proses dan Tujuan Pendidikan Islam
Authors: Farhan Yosef , Hambali Adang , Basri Hasan
Published: March 2024

This study aims to describe the results of a study on the concept of "takhallaqu bi akhlaqillah" as a process and goal of Islamic education. To describe these objectives, a qualitative research approach and library research methods are used. Study materials in the form of books, journal articles, and other research results are collected, classified, reduced and analyzed to obtain conclusions. The results of the study found that "takhallaqu bi akhlaqillah" which implies behaving and behaving in accordance with the teachings and moral values emphasized in Islam is a reference for the process and goals of Islamic education. The Prophet Muhammad SAW, who was expressly stated to have Al-Quran morals and noble character, was a role model or uswah hasanah for the Muslim community and by following him every Muslim or Muslim community has had the morals of the Koran and has incarnated uluhiyah qualities in daily life a day for a happy, meaningful, rewarding life
Implementasi Sistem Penyampaian Jasa Pendidikan di SMKN 1 Cijulang
Authors: Indah Sari Rini , Apandi Irfan , Sugiarti Anja , Pitriyani Pipin , Ilmi Irpan
Published: March 2024

The educational service delivery system is part one of marketing management. Marketing management for educational institutions, especially madrasas, is needed in line with the increasingly competitive competition between schools. Marketing is needed by educational institutions in building a positive image. If the institution has a good view in the eyes of the community, it is likely that it will be easier to overcome competition. The purpose of this research is to describe the description of the implementation of the education service delivery system. This research is a qualitative research, with data collection methods, namely: observation, interviews, documentation. The results of the study show that the service delivery system or education marketing carried out by SMKN 1Cijulang is by using internal marketing, external marketing and interactive marketing.
Manajemen Bimbingan Belajar di Sekolah SMA Negeri 1 Langkaplancar Pangandaran
Authors: Fauziah Sri Nurhilmi , Nurfadilah Nada , Saepudin Asep
Published: March 2024

The tutoring is a process of providing assistance to individuals that is carried out continuously so that a change occurs within the individual. The aim of the research is to explore how tutoring is managed at SMA Negeri 1 Langkaplancar Pangandaran. This research method is a qualitative descriptive research method. The technique in this research uses observation, interviews and documentation methods. The results of the research show that the management of tutoring at SMA Negeri 1 Langkaplancar is prepared through certain programs, namely guidance and counseling programs which have been included in scheduled activity plans, so that they can help students achieve optimal development.
Manajemen Diagnosis Kesulitan Belajar di SMPN 1 Langkaplancar
Authors: Nurlina Pajrin , Endi heryadi Elita Putri Melati , Apit Apit
Published: March 2024

The diagnostic management of learning difficulties can be understood as an effort to manage or control the difficulties experienced by students in order to achieve maximum possible results in achieving previously agreed goals. The learning difficulties examined in this research are only limited to the diagnostic management of learning difficulties, especially students' difficulties in achieving learning outcomes or abilities, in this case students have intelligence that is not below average but have poor learning abilities. This research aims to determine the management of the diagnosis of learning difficulties experienced by students at SMPN 1 Langkaplancar as well as the causes and appropriate treatment methods for the difficulties faced. The subjects of this research were instructors or supervising teachers and students of SMPN 1 Langkaplancar. The results of research in the field show that there are many factors that cause learning difficulties, one of which is that the material is given in a monotonous way, which has an impact on not maximizing absorption and focus management which results in learning difficulties for students.
Manajemen Evaluasi Keberhasilan Pelaksanaan Bimbingan Belajar di SMAN 1 Parigi
Authors: Aziz Aidah Fitri Robi'ah , Nurohmah Irma , Mutia Azlika Avilla , Farid Hilman
Published: March 2024

This research aims to describe the evaluation management of the success of implementing tutoring at SMAN 1 Parigi by focusing on the role of guidance and counseling teachers in supporting academic achievement and student development. The research method used in this research is a qualitative approach with descriptive methods. The research results show that the management of evaluating the success of implementing tutoring at SMAN 1 Parigi is carried out by subject teachers and homeroom teachers. Tutoring is provided with an academic focus, with an emphasis on effective time management and appropriate study methods. In terms of managing the evaluation of the success of tutoring, guidance and counseling teachers rely on student report cards from UTS/UAS, as well as certificates from extracurricular activities. The main obstacle faced is students' low learning motivation, which is influenced by environmental factors, peers, lack of family support, and less interesting learning methods. Counseling teachers act as motivators, good listeners, and givers of advice to overcome student problems. Even though guidance and counseling teachers try to implement positive discipline, physical punishment has been replaced by memorizing surahs, lesson materials, or reciting prayers. However, challenges arise when only a small percentage of students show positive changes, while others continue to face behavioral and academic problems. This is related to the student's character and lack of family support. This research provides in-depth insight into the management of guidance and counseling in high schools, especially at SMAN 1 Parigi, and highlights the critical role of guidance and counseling teachers in helping students achieve academic achievement and overcome social challenges.
Menilik Manajemen Bimbingan Kelompok di SMKN 1 Cijulang
Authors: Istiqomah Elsa , Febrian Rosiva , Jaelani Agung
Published: March 2024

This research aims to determine the implementation of group guidance management at SMK Negeri 1 Cijulang. The method used in this research is a qualitative approach with qualitative descriptive methods. Data collection techniques in this research use techniques adapted to the situation and conditions in the research field, including interview, observation and documentation techniques. The research results showed that the group guidance management program was not implemented because there were several inhibiting factors in its implementation, including guidance and counseling teachers having difficulty arranging assessment time, class hours not being given due to limited classroom space, and class hours being full because they were mostly used for practicums. This results in group guidance management not being implemented well.
Strategi Layanan Bimbingan dan Konseling dalam Membentuk Penanaman Minat Pembelajaran Sebagai Upaya Mencegah Pengangguran di SMK Bhakti Kencana Pangandaran
Authors: Andiani Lulu , Zahara Dela , Febriyanti Nurafilah , Widayanti Widayanti
Published: March 2024

This research aims to explore strategies for guidance and counseling services in cultivating an interest in learning that can be effective in preventing unemployment at SMK Bhakti Kencana Pangandaran. This research method uses a qualitative approach with a descriptive approach. The results of the study found that the most effective strategy in minimizing poverty and unemployment in Indonesia is held by educational institutions that guide students to gain skills in getting jobs. Supporting the success of the strategy depends on two factors, namely educators and students in achieving learning. Therefore, educators must provide trial classes and hold MOUs with companies, on the other hand, students must be consistent with the learning they are interested in.
Green Innovation and Financial Performance: Bridging the Profitability-Sustainability Gap
Authors: Rasheed Shahid , Farooq Prof. Dr. Syed Umar , Qazi Dr. Umer
Published: March 2024

In the current era of a knowledge-based green economy, green innovation has emerged as an important driver for firms to improve their financial performance. Recent studies have emphasized the significance of green innovation in addressing environmental degradation and enhancing financial performance. Few studies have been conducted about green innovation and its effects within the context of Pakistan. This study seeks to examine the impact of green innovation on the financial performance of publicly listed firms on the Pakistan Stock Exchange (PSX). The study utilized a dataset comprising 2702 observations from 351 listed companies from 2013 to 2021. The data was analyzed using weighted least square regression analysis. The study's empirical research indicates that Green Innovation has a statistically modest yet positive effect on Financial Performance in Pakistan. The research indicates that Green Innovation is significant for Financial Performance in developing countries like Pakistan. The study's findings and policy recommendations are significant for managers of various companies listed at PSX and policymakers. They can help in addressing environmental degradation and promoting sustainable development by implementing green innovation practices.
The Use of the Tilawati Mobile Android Application as an Effort to Assist the Learning Process of Reading the Qur'an for the Elderly Community in the Bogor Mengaji Class
Authors: Ningsih Indah Wahyu , Wahidin Unang , Mailana Agus , Priyatna Muhamad , Supriyani Yuli
Published: March 2024

Kegiatan pengabdian masyarakat ini bertujuan untuk mengatasi tingginya angka buta aksara Al-Qur'an di Indonesia, khususnya di Desa Kedung Halang, dengan memberikan pembinaan literasi digital menggunakan Aplikasi Android Tilawati Mobile. Kegiatan ini bertujuan untuk meningkatkan kualitas membaca Al-Qur'an bagi masyarakat lansia di kelompok pengajian Bogor Mengaji dan meningkatkan literasi digital bagi para tutor. Program ini memberikan manfaat bagi berbagai pihak, antara lain Warga Belajar Bogor Mengaji, Dosen Tetap Prodi Pendidikan Agama Islam STAI Al-Hidayah Bogor, dan STAI Al-Hidayah Bogor. Kendala utama yang dihadapi oleh masyarakat lansia antara lain keterbatasan waktu belajar dan keterbatasan media pembelajaran. Aplikasi Tilawati Mobile Android memberikan kemudahan belajar Al-Qur'an dengan cara mendengarkan dan melihat maqra' yang dibaca oleh Qori, sehingga pembelajar dapat mengakses Al-Qur'an kapanpun dan dimanapun. Model pembelajaran yang didukung teknologi ini bertujuan untuk membuat pembelajaran Al-Qur'an menjadi lebih mudah dan menyenangkan bagi masyarakat lansia.
Rationale and design of a prospective, open-label, randomized, multicentric clinical trial on the role of drug-coated balloons for bifurcation coronary lesions: the PRO-DAVID study
Authors: Prvulović Đeiti , Cortese Bernardo
Published: March 2024

Background. Coronary bifurcation lesions (CBL) are associated with impaired outcome. The role of drug-coated balloons (DCB) in this setting has been only investigated in small studies so far. Aim. We here describe the design of PRO-DAVID study, aiming at investigating the clinical outcomes of a “provisional DCB” versus a "standard" approach (provisional or upfront two stent techniques) for the treatment of complex CBL. Methods and results. The PRO-DAVID trial is a prospective, open-label, randomized, multicentric clinical trial of the interventions with true CBL (Medina 1,0,1; 1,1,1; 0,1,1) of unprotected left main (LM), and non-left main (non-LM) CBL with affected significant side branche (SB). The study hypothesis is that a “provisional DCB approach” with PCI using first DCB in SB after optimal predilatation and then DES implantation in the main vessel will be non-inferior to standard bifurcation-PCI as per EBC recommendations. The calculated sample size is 602 patients in total, and allocation is 1:1. The primary study endpoint is a composite of cardiac death, target vessel MI, or clinically-driven target lesion revascularization (TLR) at 12 months, and patients will be followed up for up to 3 years. Implications. CBL management with stents only is associated with impaired outcome, and some preliminary data on the performance of DCB show their safety and efficacy in this setting. PRO DAVID study is an adequately powered randomized trial with clinical endpoints aimed to test DCB use in true CBL.
Prognostic value of clinical and microbiological parameters in COVID-19: the COMEPA study
Authors: Veronese Nicola , Noale Marianna , La Carrubba Anna , Carruba Luca , Ciriminna Stefano , Pollicino Francesco , Saguto Dario , De Grazia Simona , Cacioppo Federica , Giammanco Giovanni M. , Costantino Claudio , Vitale Francesco , Affronti Marco , Morgante Maria Chiara , Randazzo Giusi , Dominguez Ligia J. , Maggi Stefania , Barbagallo Mario , the COMEPA study authors
Published: March 2024

Purpose. Clusters’ analysis may indicate distinct phenotypes and symptom profiles potentially due to differing pathophysiology and needing different clinical approaches in COVID-19. However, the research about clusters combining clinical and microbiological information is still limited. The purpose of our study was to examine the prognostic role of clusters, including clinical and microbiological parameters in terms of severity of lung involvement, in-hospital mortality, and the occurrence of long COVID. Methods. Information regarding COVID-19, mortality, severity of lung involvement derived from medical records; long COVID symptomatology was ascertained using phone calls. A k-means clustering method was considered to partition data into clusters considering typical symptoms of COVID-19 present at hospital admission and SarsCov2 variants. Results. Our analysis identified among 414 patients (mean age: 65 years; males: 59.9%) four different clusters. Cluster 1: higher prevalence of respiratory COVID symptoms at hospital admission; Cluster 2: higher frequency of non-respiratory COVID symptoms and a higher prevalence of the Alpha variant; Cluster 3: older subjects and more frequently men, reporting more severe medical conditions and with a higher prevalence of Wild type variant; Cluster 4: patients that more often reported general and gastrointestinal COVID symptoms at the admission. From a prognostic point of view, patients in cluster 3 more frequently died and were admitted in a nursing home, with significantly lower presence of long COVID symptomatology. Conclusions. Clusters combining clinical and microbiological information in individuals hospitalized with COVID-19 that had different not only different profiles, but also different prognostic values, also in terms of long COVID.
Brain drain: Mitigatory strategies for a critical issue affecting Italy since over 50 years
Authors: Di Guardo Giovanni
Published: March 2024

Brain drain, a profuse haemorrhage of brilliant female and male minds, is known to affect Italy and the overall Italian Society since over 50 years. Its obvious consequence is the alarming and persistent loss of scientific, educational and creative talents who, after getting graduated in one of our public Universities, leave the Country in search of more appealing, rewarding and successful professional and scientific opportunities abroad, thereby substantially contributing to make more prosperous the economy and the society of the Nations hosting them, with special emphasis on European Union (EU) Countries.
EKSTRAKSI ASAM LEMAK MIKROALGA Tetraselmi chuii DENGAN MINYAK ZAITUN
Authors: Suprianti Tuti
Published: March 2024

Tetraselmi chuii merupakan mikroalga dari golongan alga hijau (Chlorophyceae) mempunyai nilai gizi tinggi, pemanfaatan nutraceutical alga secara komersial telah banyak diterapkan, antara lain sebagai bahan makanan, energi biomassa, pupuk pertanian, dan dalam industri farmasi. Penelitian ini bertujuan mengetahui komposisi asam lemak hasil ekstrak Tetraselmi chuii dengan menggunakan pelarut minyak zaitun. Metode yang digunakan dalam penelitian ini adalah mengekstrak asam lemak Tetraselmi chuii menggunakan minyak zaitun dengan perbandingan konsetrasi (gram mikroalga : mL minyak zaitun) yaitu, 1:10 b/v, 1:15 b/v 1:20 b/v, dan 1:25 b/v. Asam lemak hasil ekstraksi dianalisis dengan GC-MS. Hasil penelitian diperoleh kadar optimum asam lemak pada perbandingan konsentrasi (gram mikroalga : mL minyak zaitun) 1:20 b/v yaitu, 50,0733 %b/v. Perbandingan konsentrasi minyak zaitun dapat meningkatkan ekstraksi asam lemak Tetraselmi chuii. Komposisi asam lemak asam lemak optimum ekstrak Tetraselmi chuii  berdasarkan   hasil GC-MS yaitu, 1,86% asam palmitoleat, 20,50% asam palmitat, 13,29% asam linoleat, 61,08% asam oleat, dan 4,57% asam stearat
PERANCANGAN DAN IMPLEMENTASI METODE KERJA YANG ERGONOMI PADA PT. CAHAYA ANUGRAH SENTOSA MAKASSAR
Authors: Yunus Kartini
Published: March 2024

Cahaya Anugrah Sentosa Makassar produces peanut egg snacks. In the production process of this egg peanut snack has a fairly high risk because the work process is carried out continuously. This process still uses human power without the use of work aids. Besides that, the process of packing egg nuts snacks isdone on the floor in a sitting position. This is very dangerous for the work force because it has a risk of occupational diseases, fatigue at work, so that workers become uncomfortable at work. The purpose ofthis study is to design ergonomic work methods in the packing section to reduce the risk of occupational diseases and will increase work productivity. The method used in this research is subjectivity analisysis and anthropometric analisis. From the subjectivity analysis it can be seen the level of operator complaints, while antropometric analysis obtained the operator’s body size which can be adjusted to design work aids. From the results of the oprator subjectivity analysis, it can be seen that the comparison of the level of complaints before and after the design of work methods. Prior to the design of the work methods, the average complaint scale has not felt pain and is not tired for along time
Aplikasi Peralatan Flexible AC transmission Systems (FACTS) Pada Sistem Tenaga Listrik
Authors: Misba Misbahuddin Buang
Published: March 2024

The power need of South Sulawesi community is increasingly in a row with technology development. At this time, with the lack of new generation and transmission facilities make voltage instability always occur. To relieve it, Flexible AC Transmission System (FACTS) is used, that is, Static Compensator (STATCOM) which its basic operating principles functions as a synchronous voltage source. This research aimed to  find out  voltage conditions and power systems losses of South Sulawesi before and after using STATCOM and determine location of STATCOM installation. This research was carried out in South Sulawesi region specially at PT. PLN (Ltd.) Business Unit of SULSELTRABAR. To determined location of STATCOM installation, Trial and Error Method is used where buses which have voltage exist near to voltage interval limit allowed, became a reference of STATCOM installation. The results shows that voltage condition before STATCOM installed, exist to voltage interval limit allowed, that is, 0.95 – 1.05 pu. However, voltage of Tonasa Tonasa, Bontoala, Pangkep70, and Tallo Lama buses exist near to voltage interval limit allowed. Based on simulation results, an exact STATCOM installation is on two buses, that is, Tonasa and Bontoala buses until voltage of mentioned four buses are improved and near to fundamental voltage, respectively. Power losses after STATCOM installed is increase because when it installed, there are conduction losses and switching losses at STATCOM
APLIKASI INFORMASI DIGITAL FAKULTAS ILMU KOMPUTER UNIVERSITAS MUSLIM INDONESIA
Authors: Tanti Tri Gustanti
Published: March 2024

The selection of the appropriate information media is very important in supporting the success of delivering information to those concerned, including the Faculty of Computer Science, University of Muslim Indonesia.Furthemore, this research is made with the title "Digital Information Application Based on Website at FIKOM – UMI " to facilitate the delivery of information from faculty staff, study program staff, lecturers and faculty leaders to students to be more efficient in terms of costs, media used to the effectiveness of delivering and receiving information.This system is designed using UML modeling. Meanwhile, the programming language used is PHP and MySQL database.The information contained is the applicable regulations, agenda or event, today's lecture status, lecturers present today, articles that support academic knowledge and all academic and non-academic information deemed necessary to be conveyed to students.
The current standard of care of inflammatory bowel disease
Authors: Wright J
Published: March 2024

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Soutenir l’insertion professionnelle des enseignant.e.s novices
Authors: Boulay Marie-France , Hamel Christine , Pomerleau Gabrielle , Carrier-Fraser Martine
Published: March 2024

Au Québec comme ailleurs dans le monde, les enseignant.e.s novices du primaire font face à plusieurs défis lors de leur insertion professionnelle. Pour mieux comprendre leur activité, un laboratoire d’analyse de l’activité a été mis en place dans l’idée de soutenir leur entrée et leur persévérance dans la profession, de même que leur développement professionnel. Cet article relate certaines tensions vécues et les besoins d’accompagnement nommés par les novices. Il met également en lumière l’importance de créer et d’assurer la pérennité d’espaces confidentiels de réflexion et de développement en dehors de l’école, ainsi que le rôle que les universités peuvent jouer à cet égard.
L’intelligence du travail enseignant à l’ère numérique
Authors: Alexandre Marie
Published: March 2024

Cet article vise à mettre en lumière l’intelligence du travail enseignant en « réponse aux défis liés à l’utilisation de la technologie et de l’intelligence artificielle en éducation » (appel de texte ). D’abord, l’apprentissage des compétences du XXIesiècle en accordant une large place à l’utilisation du numérique, infère un nouveau rôle enseignant. Un accent particulier mis sur l’apprentissage et l’environnement contribue à configurer des pratiques pédagogiques en réponse aux besoins des élèves. L’examen du nouveau Référentiel de compétences professionnelles : Profession enseignante (Gouvernement du Québec, 2020) fait ressortir quatre schèmes organisateurs de l’activité enseignante en situation : l’apprentissage, l’environnement, la collectivité/collaboration et le développement professionnel continu. La conclusion fait valoir l’importance de la mission fondamentale enseignante afin de faire face à la complexité du monde.
L’Agneau que donc je suis : l’indistinction du devenir-disciple en Jean
Authors: Doane Sébastien
Published: March 2024

Quel est l’animal que je suis (être/suivre) ? Cet article répond à l’invitation du philosophe Jacques Derrida (2006) de prendre en compte l’animal, en l’occurrence l’agneau johannique, de le regarder, de se laisser regarder par lui et de le suivre pour discerner de nouvelles possibilités ontologiques. À partir de la description du Jésus johannique plus qu’humain de Stephen Moore (2017) et du concept d’agencement de Deleuze et Guattari, je cartographie la configuration des disciples et du lectorat de l’Évangile selon Jean comme un agencement qui brouille les frontières cartésiennes entre humains, animaux et végétaux. L’objectif est de formuler une réponse créative à la crise écologique qui s’inscrit dans la ligne du modèle d’indistinction délimitée par Calarco (2015) pour abandonner la prétention des humains à l’unicité en concevant de nouvelles dynamiques interespèces pour permettre aux animaux (humains et non-humains) de se développer ensemble dans un monde en difficulté.
Mana nauda. Mācību grāmata vieglajā valodā
Authors: Ciemleja Guna
Published: March 2024

Prasme rīkoties ar naudu ir svarīga ikvienam. Mācību līdzeklis ir veidots vieglajā valodā, lai sarežģītus jautājumus paskaidrotu ar vienkāršiem vārdiem. Grāmatā ir aplūkotas dažādas tēmas, kas saistītas ar naudas pelnīšanu, tērēšanu un uzkrāšanu, bankas pakalpojumu izmantošanu, aizņemšanos un riskiem, kā arī ir sniegti piemēri, kā analizēt savus izdevumus, veidot bilanci un budžetu.
Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model
Authors: Xue Yunlu , Zhou Yimin , Cepko Constance L.
Published: March 2024

Retinitis pigmentosa (RP) is a prevalent inherited retinal degenerative disease worldwide, affecting 1 in 4,000 people. The disease is characterized by an initial loss of night vision followed by a loss of daylight and color vision. Many of the RP disease genes are expressed in the rod photoreceptors, the cell type that initiates dim light vision. Following loss of rods, the cone photoreceptors, which initiate daylight vision, also are affected and can die leading to total loss of vision. The reasons for loss of cone vision are not entirely clear, but appear to be due to loss of the rods. Previously we showed that overexpressing Txnip, an α-arrestin protein, in mouse models of RP using AAV gene therapy prolonged the survival of RP cones (Xue et al., 2021). At least part of the mechanism for cone survival was a switch in the fuel source, from glucose to lactate. In addition, the mitochondria of cones were both morphologically and functionally improved by delivery of Txnip. We have gone on to test several alleles of Txnip for the ability to prolong cone survival in
rd1
, a mouse model of RP. In addition, proteins that bind to Txnip and/or have homology to Txnip were tested. Five different deletion alleles of Txnip were expressed in cones or the retinal pigmented epithelium (RPE). Here we show that the C-terminal half of Txnip (149-397aa) is sufficient to remove GLUT1 from the RPE cell surface, and improved
rd1
cone survival when expressed specifically in the RPE. Overexpressing Arrdc4, an α-arrestin that shares 60% similar protein sequence to Txnip, reduced
rd1
cone survival. Reduction of the expression of HSP90AB1, a protein that interacts with Txnip and regulates metabolism, improved the survival of
rd1
cones alone and was additive for cone survival when combined with Txnip. However, full length Txnip with a single amino acid change, C247S, as we tested in our original study, remains the most highly efficacious form of the gene for cone rescue. The above observations suggest that only a subset of the hypothesized and known activities of Txnip play a role in promoting RP cone survival, and that the activities of Txnip in the RPE differ from those in cone photoreceptors.
Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists
Authors: Sheng Danqi , Yue Chenxi , Jin Fei , Wang Yao , Ichikawa Muneyoshi , Yu Ye , Guo Chang-Run , Hattori Motoyuki
Published: March 2024

P2X receptors are extracellular ATP-gated ion channels that form homo-or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes such as neurotransmission, inflammation, pain, and cancer. As a result, P2X receptors have attracted considerable interest as drug targets, and various competitive inhibitors have been developed. However, although several P2X receptor structures from different subtypes have been reported, the limited structural information of P2X receptors in complex with competitive antagonists hampers the understanding of orthosteric inhibition, hindering the further design and optimization of those antagonists for drug discovery.Here, we determined the cryo-EM structures of the mammalian P2X7 receptor in complex with two classical competitive antagonists of pyridoxal-5’-phosphate derivatives, PPNDS and PPADS, at 3.3 and 3.6 Å resolution, respectively, and performed structure-based mutational analysis by patch-clamp recording as well as MD simulations. Our structures revealed the orthosteric site for PPADS/PPNDS, and structural comparison with the previously reported apo-and ATP-bound structures showed how PPADS/PPNDS binding inhibits the conformational changes associated with channel activation. In addition, structure-based mutational analysis identified key residues involved in the PPNDS sensitivity of P2X1 and P2X3, which are known to have higher affinity for PPADS/PPNDS than other P2X subtypes. Overall, our work provides structural insights into the orthosteric inhibition and subtype specificity of P2X receptors by the classical P2X antagonists, pyridoxal-5’-phosphate derivatives, thereby facilitating the rational design of novel competitive antagonists for P2X receptors.
PURA Syndrome-causing mutations impair PUR-domain integrity and affect P-body association
Authors: Proske Marcel , Janowski Robert , Bacher Sabrina , Kang Hyun-Seo , Monecke Thomas , Köhler Tony , Hutten Saskia , Tretter Jana , Crois Anna , Molitor Lena , Varela-Rial Alejandro , Fino Roberto , Donati Elisa , Fabritiis Gianni De , Dormann Dorothee , Sattler Michael , Niessing Dierk
Published: March 2024

Mutations in the human
PURA
gene cause the neuro-developmental PURA syndrome. In contrast to several other mono-genetic disorders, almost all reported mutations in this nucleic acid binding protein result in the full disease penetrance. In this study, we observed that patient mutations across PURA impair its previously reported co-localization with processing bodies. These mutations either destroyed the folding integrity, RNA binding or dimerization of PURA. We also solved the crystal structures of the N- and C-terminal PUR domains of human PURA and combined them with molecular dynamics simulations and NMR measurements. The observed unusually high dynamics and structural promiscuity of PURA indicated that this protein is particularly susceptible to mutations impairing its structural integrity. It offers an explanation why even conservative mutations across PURA result in the full penetrance of symptoms in patients with PURA syndrome.
A microRNA that controls the emergence of embryonic movement
Authors: Menzies Jonathan A. C. , Chagas Andre M. , Alonso Claudio R.
Published: March 2024

Movement is a key feature of animal systems, yet its embryonic origins are not fully understood. Here we investigate the genetic basis underlying the embryonic onset of movement in
Drosophila
focusing on the role played by small non-coding RNAs (microRNAs, miRNAs). To this end, we first develop a quantitative behavioural pipeline capable of tracking embryonic movement in large populations of fly embryos, and using this system, discover that the
Drosophila
miRNA
miR-2b-1
plays a role in the emergence of movement. Through the combination of spectral analysis of embryonic motor patterns, cell sorting and RNA
in situs
, genetic reconstitution tests, and neural optical imaging we define that
miR-2b-1
influences the emergence of embryonic movement by exerting actions in the developing nervous system. Furthermore, through the combination of bioinformatics coupled to genetic manipulation of miRNA expression and phenocopy tests we identify a previously uncharacterised (but evolutionarily conserved) chloride channel encoding gene – which we term
Janus
– as a genetic target that mechanistically links
miR-2b-1
to the onset of movement. Cell-specific genetic reconstitution of
miR-2b-1
expression in a null miRNA mutant background, followed by behavioural assays and target gene analyses, suggest that
miR-2b-1
affects the emergence of movement through effects in sensory elements of the embryonic circuitry, rather than in the motor domain. Our work thus reports the first miRNA system capable of regulating embryonic movement, suggesting that other miRNAs are likely to play a role in this key developmental process in
Drosophila
as well as in other species.
Effectiveness of a Standardised Educational Package for Mothers of Children with Severe Acute Malnutrition: A Hospital-based Randomised Controlled Trial
Authors: Singh Pushpendra , Das Ghanshyam , Gaur Ajay Kumar , Bansal Satvik Chaitanya
Published: March 2024

Introduction: Malnutrition is a major public health problem, especially in Low- and Middle-Income Countries (LMICs), contributing significantly to under-five mortality. New strategies are needed to enhance outcomes for childhood malnutrition. Aim: To evaluate the impact of an educational package on mothers of children hospitalised with Severe Acute Malnutrition (SAM). Materials and Methods: This was a hospital-based randomised controlled trial conducted in the Department of Paediatrics at Gajra Raja Medical College, Gwalior, Madhya Pradesh, India. Only children hospitalised between 6 months and 59 months of age with SAM were included and randomised into an Intervention group and a Control group. In the intervention group, verbal, pictorial, and demonstration techniques were used to educate the mothers. Anthropometric measurements of malnourished children and maternal knowledge scores were compared at baseline, 15 days, and two months postdischarge. Frequency and percentage were calculated for qualitative data analysis, while mean values with standard deviations were calculated for quantitative data. Independent t-tests and paired t-tests were applied, and paired t-tests were used for within-group comparisons at different time points. Data was entered into Microsoft Excel software, and analysis was performed using Statistical Package for Social Sciences (SPSS) version 22.0. Results: The mean age of children was 1.4±0.9 years, with the majority below two years of age (86.4%). The male-to-female ratio was 1.04 (n=154 versus n=148). Most subjects belonged to lower or upper-lower socio-economic classes (75%). Mothers were commonly educated up to the primary school level (48%). Both study groups had similar socio-demographic profiles. There was a significant weight gain (p-value <0.01) and height gain (p-value <0.01) in the intervention group at the end of the follow-up period. Maternal knowledge gain in the intervention group was also significantly higher than in the control group (p-value <0.01). Conclusion: This study supports maternal educational strategies as a low-cost intervention to address early childhood malnutrition in resource-limited settings. Further research is needed to standardise the intervention and assess long-term impact.
Risk Assessment of Obstructive Sleep Apnoea Symptoms and Its Correlation with Oral Manifestations: A Cross-sectional Study
Authors: Yathish TR , Manjula CG
Published: March 2024

Introduction: Obstructive Sleep Apnoea (OSA) is the most common sleep-related breathing disorder seen in all age groups. The aetiology is multifactorial, including factors such as obesity, aging, stress, and a sedentary lifestyle. Poor knowledge about diagnostic options, management, and consequences of improper treatment may contribute to morbidity and mortality. Berlin Questionnaires (BQ) are simple, low-cost, non-invasive tools that can be used to assess the risk of OSA. Screening subjects using questionnaires and oral examinations for a multidisciplinary approach to treat OSA is essential. Aim: To assess the risk of OSA symptoms and their association with oral manifestations among students. Materials and Methods: This cross-sectional study was conducted among medical students aged between 18 and 24 years. Three hundred medical students (171 males, 129 females) willing to participate in the study were included. Responses to the Berlin and oral health questionnaires were collected, and oral examinations were performed. Statistical analysis was conducted using Epi Info software. Kruskal-Wallis H test and one-way Analysis Of Variance (ANOVA) were carried out to evaluate significance in different groups and to examine associations between OSA, oral health, and other variables. Results: The collected data were statistically analysed. In the present study, 35 subjects (11.67%) were classified as highrisk and 265 subjects (88.33%) as low-risk by the BQ. The prevalence of OSA in the present study was 12.87% in males and 10.08% in females. High-risk subjects were educated, motivated, and referred for confirmatory diagnostic tests and early treatment. Conclusion: The prevalence of OSA in the present study was 12.87% in males and 10.08% in females. Emphasis should be placed on highlighting the clinical aspects related to OSA and its relation to oral health. There is a great need to educate and motivate dental and medical students and professionals about OSA by conducting health education programs.
Impact of Albumin Therapy in Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Authors: Kumar Bonchanpalli Mohan , Malik Mustahsin , Kumar Rajesh
Published: March 2024

Introduction: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Due to the limited understanding of this disease, research has quickly extended towards identifying biomarkers to predict its prognosis and progression. Aim: To explore the impact of albumin infusion on critically ill COVID-19 patients. Materials and Methods: In this retrospective cohort study, a total of 150 severe COVID-19 patients aged 18 to 65 years were enrolled. These patients were categorised into the no albumin infusion group (n=61), consisting of those who did not undergo albumin transfusion during their treatment, and the albumin infusion group (n=89), comprising patients who received albumin transfusion as part of their treatment protocol. Assessments of hospitalisation included the Sequential Organ Failure Assessment (SOFA), and Acute Physiology and Chronic Health Evaluation (APACHE-II) scores obtained at baseline and day 5. Unpaired t-tests, Chi-square tests, and paired t-tests were used for analysis. Results: The mean values of Haemoglobin (Hb), eosinophils, Random Blood Sugar (RBS), Mean Corpuscular Volume (MCV), total protein, serum urea, serum bilirubin, Prothrombin Time (PT), International Normalised Ratio (INR), Interleukin 6 (IL-6), Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), and D-dimer exhibited significant differences between the two groups. The average duration of vasopressor usage and Intensive Care Unit (ICU) stay were significantly reduced in the albumin infusion group (3.50±1.55 days and 8.70±4.20 days, respectively) compared to no albumin infusion group (4.33±1.05 days and 12.80±3.43 days, respectively). The albumin infusion group also displayed a lower incidence of Renal Replacement Therapy (RRT) and poorer ICU outcomes. Conclusion: The intravenous administration of albumin did not exhibit a significant impact on mortality. However, albumin transfusion in patients with severe COVID-19 who initially had albumin levels <3 g/dL demonstrated a notable reduction in the requirement for vasopressors, RRT, and the length of ICU stay