bluuebunny/crossref_metadata_2025 huggingface dataset:
Articular involvement, steroid treatment and fibromyalgia are the main determinants of patient-physician discordance in systemic lupus erythematosus
Authors: Elefante Elena , Tani Chiara , Stagnaro Chiara , Signorini Viola , Parma Alice , Carli Linda , Zucchi Dina , Ferro Francesco , Mosca Marta
Published: October 2020

Background

Remission or the lowest possible disease activity is the main target in the management of systemic lupus erythematosus (SLE). Anyway, conflicting data are present in the literature regarding the correlation between physician-driven definitions and patient perception of the disease. The objective of this study is to evaluate the relationship between the definition of lupus low disease activity state (LLDAS) and patient’s health-related quality of life (HRQoL).

Methods

This is a cross-sectional, monocentric study. Adult SLE patients were included. For each patient, demographics, disease duration, medications, comorbidities, organ damage, active disease manifestations and SELENA-SLEDAI were assessed. Patients have been categorised as follows: LLDAS, remission and active disease. Each patient completed the following patient-reported outcomes (PROs): SF-36, LIT, FACIT-Fatigue and SLAQ. A SLAQ score < 6 (25° percentile of our cohort) was used as the cut-off value to define a low disease activity state according to patient self-evaluation.

Results

We enrolled 259 consecutive SLE patients (mainly female and Caucasian, mean age 45.33 ± 13.14 years, median disease duration 14 years). 80.3% were in LLDAS, of whom 82.2% were in remission; 19.7% were active. No differences emerged for any of the PROs used between the LLDAS and the active group.

Considering the LLDAS subgroup, we identified 56 patients with a subjective low disease activity (SLAQ < 6) and we defined them as “concordant”; the remaining 152 patients in LLDAS presented a subjective active disease (SLAQ ≥ 6) and were defined “discordant”. Discordant patients presented more frequently ongoing and past joint involvement (p < 0.05) and a diagnosis of fibromyalgia (p < 0.01); furthermore, they were more likely to be on glucocorticoid therapy (p < 0.01). Discordant patients showed a significantly poorer HRQoL, assessed by all PROs (p < 0.0001).

Conclusions

Joint involvement, glucocorticoid therapy and comorbid fibromyalgia resulted to be the most important variables determining the poor concordance between patient and physician perspective on the disease.
Effects of miR-101-3p on goat granulosa cells in vitro and ovarian development in vivo via STC1
Authors: An Xiaopeng , Ma Haidong , Liu Yuhan , Li Fu , Song Yuxuan , Li Guang , Bai Yueyu , Cao Binyun
Published: October 2020

Background

MiRNAs act as pivotal post-transcriptional gene mediators in the regulation of diverse biological processes, including proliferation, development and apoptosis. Our previous study has showed that miR-101-3p is differentially expressed in dairy goat ovaries compared single with multiple litters. The objective of this research was to explore the potential function and molecular mechanism of miR-101-3p via its target STC1 in goat ovarian growth and development.

Results

cDNA libraries were constructed using goat granulosa cells transfected with miR-101-3p mimics and negative control by RNA-sequencing. In total, 142 differentially expressed unigenes (DEGs) were detected between two libraries, including 78 down-regulated and 64 up-regulated genes. GO and KEGG enrichment analysis showed the potential impacts of DEGs on ovarian development. STC1 was singled out from DEGs for further research owing to it regulates reproductive-related processes. In vitro, bioinformatics analysis and 3′-UTR assays confirmed that STC1 was a target of miR-101-3p. ELISA was performed to detect the estrogen (E2) and progesterone (P4) levels. CCK8, EdU and flow cytometry assays were performed to detect the proliferation and apoptosis of granulosa cells. Results showed that miR-101-3p regulated STAR, CYP19A1, CYP11A1 and 3β-HSD steroid hormone synthesis-associated genes by STC1 depletion, thus promoted E2 and P4 secretions. MiR-101-3p also affected the key protein PI3K, PTEN, AKT and mTOR in PI3K-AKT pathway by STC1, thereby suppressing proliferation and promoting apoptosis of granulosa cells. In vivo, the distribution and expression levels of miR-101-3p in mouse ovaries were determined through fluorescence in situ hybridisation (FISH). Immunohistochemistry results showed that STC1 expression was suppressed in mouse ovaries in miR-101-3p-agonist and siRNA-STC1 groups. Small and stunted ovarian fragments, decreased numbers of follicles at diverse stages were observed using Hematoxylin-eosin (HE) staining, thereby showing unusual ovarian development after miR-101-3p overexpression or STC1 depletion. Inhibition of miR-101-3p manifested opposite results.

Conclusions

Taken together, our results demonstrated a regulatory mechanism of miR-101-3p via STC1 in goat granulosa cells, and offered the first in vivo example of miR-101-3p and STC1 functions required for ovarian development.
An analysis of users’ preferences on learning management systems: a case on German versus Spanish students
Authors: Tinmaz Hasan , Lee Jin Hwa
Published: October 2020

The recent advancements in information and communication technologies have altered instructional contexts and re-shaped them into smart learning environments. One of the most common practices of these environments are learning management systems (LMS) where the learners and instructors utilize a software platform to fulfill, support and manage instructional activities around predefined objectives. Successful implementations of LMS have brought a variety on its usage from different cultures, genders, age groups or schooling levels. Hence, this study focuses on understanding the role of culture on LMS design, in along with the effects of gender, age and school year variables. The study participants were German (n = 83) and Spanish (n = 83) university students attending a fully online course offered by a South Korean university. At the end of the course, the students were asked to fulfill a survey on effective LMS design by pointing which features of LMS were more important for them. The survey included twenty questions on four major design factors; content management (six items), ease of use (five items), communication within LMS (four item) and screen design (five items). The dataset was analyzed by non-parametric statistical techniques around four variables on four dimensions (and their related survey questions). The most important result was insufficiency of one unique LMS design for all students which demonstrates the necessity of student demographics tailored smart systems. Additionally, age and gender variables were not making significant differences on LMS design as much as culture and school year variables. The study also revealed that while German students would appreciate goal-oriented individual learning, Spanish students would value process-oriented group learning with active communication. Furthermore, many features of LMS were highly valued by the freshman students more than other levels. The paper discusses these variables with possible explanations from the literature and depicts implementations for future design practices.
Method of Ga removal from a specimen on a microelectromechanical system-based chip for in-situ transmission electron microscopy
Authors: Kwon Yena , An Byeong-Seon , Shin Yeon-Ju , Yang Cheol-Woong
Published: October 2020

In-situ transmission electron microscopy (TEM) holders that employ a chip-type specimen stage have been widely utilized in recent years. The specimen on the microelectromechanical system (MEMS)-based chip is commonly prepared by focused ion beam (FIB) milling and ex-situ lift-out (EXLO). However, the FIB-milled thin-foil specimens are inevitably contaminated with Ga+ ions. When these specimens are heated for real time observation, the Ga+ ions influence the reaction or aggregate in the protection layer. An effective method of removing the Ga residue by Ar+ ion milling within FIB system was explored in this study. However, the Ga residue remained in the thin-foil specimen that was extracted by EXLO from the trench after the conduct of Ar+ ion milling. To address this drawback, the thin-foil specimen was attached to an FIB lift-out grid, subjected to Ar+ ion milling, and subsequently transferred to an MEMS-based chip by EXLO. The removal of the Ga residue was confirmed by energy dispersive spectroscopy.
Investigation of cable effects in spectral induced polarization imaging at the field scale using multicore and coaxial cables
Authors: Flores Orozco Adrian , Aigner Lukas , Gallistl Jakob
Published: October 2020

The spectral induced polarization (SIP) method has emerged as a well-suited laboratory technique to characterize hydrogeologic and biogeochemical parameters in soil samples. However, field applications of the SIP imaging method are still rare, which can be attributed to the particular care required to minimize the contamination of the data by electromagnetic coupling. To date, field procedures rely on the use of two different cables separating the current and potential dipoles to improve the quality of the SIP readings, although this increases the efforts in the field and might reduce the depth of investigation or the spatial resolution of the data. To overcome these limitations, we have investigated the use of a single coaxial cable, as an alternative to improve data quality and simplify field procedures. We evaluate SIP imaging data collected with the same measuring device using a coaxial cable and a combination of multicore cables of different lengths and manufacturers. Data sets collected with a single coaxial cable reveal a significantly lower number of outliers and a high spatial consistency between the phase-lag readings, even for measurements collected with a coaxial cable five times longer than the length of the profile. Furthermore, the data collected with coaxial cables reveal an improved quality for deeper measurements (with a lower signal-to-noise ratio) in comparison to data sets collected with separate cables. Our results demonstrate that the use of coaxial cables might permit the collection of SIP readings with high quality and similar field procedures to those used in resistivity surveys.
Mimetic finite-difference coupled-domain solver for anisotropic media
Authors: Sethi Harpreet , Shragge Jeffrey , Tsvankin Ilya
Published: October 2020

Accurately modeling full-wavefield solutions at and near the seafloor is challenging for conventional single-domain elastic finite-difference (FD) methods. Because they treat the fluid layer as a solid with zero shear-wave velocity, the energy partitioning for body and surface waves at the seafloor is distorted. This results in incorrect fluid/solid boundary conditions, which has significant implications for imaging and inversion applications that use amplitude information for model building. To address these issues, here we use mimetic FD (MFD) operators to develop and test a numerical approach for accurately implementing the boundary conditions at a fluid/solid interface. Instead of employing a single “global” model domain, we partition the full grid into two subdomains that represent the acoustic and elastic (possibly anisotropic) media. A novel split-node approach based on one-sided MFD operators is introduced to distribute grid points at the fluid/solid interface and satisfy the wave equation and the boundary conditions. Numerical examples demonstrate that such MFD operators achieve stable implementation of the boundary conditions with the same (fourth) order of spatial accuracy as that inside the split-domain interiors. We compare the wavefields produced by the MFD scheme with those from a more computationally expensive spectral-element method to validate our algorithm. The modeling results help analyze the events associated with the fluid/solid (seafloor) interface and provide valuable insights into the horizontal displacement or velocity components (e.g., recorded in ocean-bottom-node data sets). The developed MFD approach can be efficiently used in elastic anisotropic imaging and inversion applications involving ocean-bottom seismic data.
Monitoring hydraulic fracture volume using borehole to surface electromagnetic and conductive proppant
Authors: Hoversten G. Michael , Schwarzbach Christoph
Published: October 2020

Numerical modeling of a North American hydraulic fracture experiment is done to demonstrate the accuracy with which the volume containing proppant could be estimated when electrically conductive proppant is used. An electromagnetic (EM) acquisition system with surface electric and magnetic field receivers and a grounded electric dipole source is simulated. The source has one electrode on the surface and one down a steel-cased lateral well that is adjacent to the lateral well that is being hydraulically fractured. The simulations are performed using measured EM noise at the site during hydraulic fracturing. A 3D OcTree finite-volume code is used that allows very fine meshing around the wells and fractures that expands rapidly toward the boundaries keeping memory requirements within available resources. The effect of the steel casings is modeled in the forward and inverse solutions. Possible scenarios for source-receiver configurations, proppant conductivity, number of perforations per frac stage, variations in the steel casing properties, as well as geometric errors in the locations of receivers and in the placement of lateral wells are considered. Hydraulic fracture stages are modeled as 3D geobodies with variability in the direction perpendicular to the well. Frac stages are embedded in a layered background model built from logged resistivities. The inversion of the EM data starts with the pre-frac data to recover the anisotropic layered background conductivity, steel casing conductivity, and susceptibility. Data differencing between the frac stage and the background or between successive frac stages is used for inversion of frac stage properties. A parametric box model is fit to each stage to estimate the volume, length, height, and mean stage conductivity. Hundreds of inversions starting from random parameter values are run to calculate parameter means and standard deviations. The mean values of the recovered volume, length, and height are all within 20% of the true values.
Cross-sectional study of Facebook addiction in a sample of Nepalese population
Authors: Atreya Alok , Nepal Samata , Thapa Prakash
Published: October 2020

Background: Facebook addiction is said to occur when an individual spends an excessive amount of time on Facebook, disrupting one’s daily activities and social life. The present study aimed to find out the level of Facebook addiction in the Nepalese context and briefly discuss the issues associated with its unintended use.

Methods: A descriptive cross-sectional study was conducted in the Department of Forensic Medicine of Lumbini Medical College. The study instrument was the Bergen Facebook Addiction Scale typed into a Google Form and sent randomly to Facebook contacts of the authors. The responses were downloaded in a Microsoft Excel spreadsheet and analyzed using Statistical Package for Social Sciences version 16.

Results: The study consisted of 103 Nepalese participants, of which 54 (52.42%) were males and 49 females (47.58%). There were 11 participants (10.68%) who had more than one Facebook account. When different approaches were applied it was observed that 8.73% (n=9) to 39.80% (n=41) were addicted to Facebook.

Conclusion: When used properly Facebook has its own advantages. Excessive use is linked with health hazards including addiction and dependency. Students who engage more on Facebook may have less time studying, leading to poor academic performance. People need to be made aware of the issues associated with the misuse of Facebook.
Beyond the dermis—high-risk invasive squamous cell carcinoma: a retrospective review
Authors: Sood Anshum , Bivona Louis , Mahkzoumi Zaineb , Hausner Petr , Miller Kenneth , Regine William F , Snider James , Ng Vincent Y
Published: October 2020

Objective:

Most cutaneous squamous cell carcinomas (cSCC) are low risk and can be treated with simple excision or ablation. High-risk cSCC require invasive treatment, including radical surgery. We present our experience in treating invasive cSCC of the pelvis and extremities.

Method:

A retrospective review of the data of patients with invasive cSCC, indicated for surgery between 2014 and 2018, from a single institution was carried out.

Results:

A total of 19 patients (nine men, 10 women) were included in the study. Mean age was 62 years; mean tumour size was 8.6cm). Of the 19 patients, five patients with paraplegia with cSCC arising from hard-to-heal ulcers died of infection or bleeding after surgery or systemic therapy. Also, nine patients with localised cSCC underwent margin-negative resection with or without radiation; one patient experienced disease relapse. Of the participants, two patients with previous transplants and multifocal aggressive cSCC underwent numerous resections but succumbed to disease, and two patients who presented with locally recurrent disease after previous positive margin resection and radiation underwent re-resection but developed recurrent disease.

Conclusions:

Prognosis for invasive cSCC largely depends on clinical setting. Tumours arising from ulcers in patients with paraplegia have a poor prognosis regardless of treatment. Invasive cSCC in transplant patients are often multifocal and often recur. Debulking procedures are associated with local recurrence despite radiation. Patients presenting with localised disease have a favourable prognosis with wide resection, flap coverage and adjuvant therapy.
Approximate Bayes Estimators of the Parameters of the Inverse Gaussian Distribution Under Different Loss Functions
Authors: Usta Ilhan , Akdede Merve
Published: October 2020

Inverse Gaussian is a popular distribution especially in the reliability and life time modelling, and thus the estimation of its unknown parameters has received considerable interest. This paper aims to obtain the Bayes estimators for the two parameters of the inverse Gaussian distribution under varied loss functions (squared error, general entropy and linear exponential). In Bayesian procedure, we consider commonly used non-informative priors such as the vague and Jeffrey’s priors, and also propose using the extension of Jeffrey’s prior. In the case where the two parameters are unknown, the Bayes estimators cannot be obtained in the closed-form. Hence, we employ two approximation methods, namely Lindley and Tierney Kadane (TK) approximations, to attain the Bayes estimates of the parameters. In this paper. the effects of considered loss functions, priors and approximation methods on Bayesian parameter estimation are also presented. The performance of Bayes estimates is compared with the corresponding classical estimates in terms of the bias and the relative efficiency throughout an extensive simulation study. The results of the comparison show that Bayes estimators obtained by TK method under linear exponential loss function using the proposed prior outperform the other estimators for estimating the parameters of inverse Gaussian distribution most of the time. Finally, a real data set is provided to illustrate the results.
Can street-level bureaucrats be nudged to increase effectiveness in welfare policy?
Authors: Visintin Emilio Paolo , Bonvin Jean-Michel , Varone Frédéric , Butera Fabrizio , Lovey Max , Rosenstein Emilie
Published: October 2020

This article investigates whether street-level bureaucrats can be incentivised to process information in ways that lead to more effective implementation decisions. It draws on the literatures on behavioural public policy (BPP) and street-level bureaucracy to analyse how civil servants implement disability insurance policy in Switzerland. We conducted a field experiment to assess whether a thought-provoking nudge improves the decisional effectiveness of street-level bureaucrats (SLBs). SLBs were assigned to either a ‘business-as-usual’ control condition, or to an experimental condition, where they were called to pay attention to vulnerability processes along the beneficiaries’ life course when making decisions. While we did not find that the thought-provoking nudge directly improved effectiveness, we found that it increased beneficiaries’ humanisation. In particular, there was some evidence for indirect positive effects of the thought-provoking nudge on effectiveness via humanisation. These findings encourage BPP researchers to consider additional dimensions such as humanisation to nudge SLBs into processing information in better ways.
Multipulsing states management in all-normal dispersion fiber laser with a fiber-based spectral filter
Authors: Khanolkar Ankita , Chong Andy
Published: October 2020

We report an experimental study of multipulsing states in an all-normal dispersion fiber laser using an all-fiber, tunable birefringent spectral filter. Various multipulsing states such as harmonic mode-locking and soliton bunches are observed by tuning the spectral filter. The multipulse evolution in this experiment relies only on the spectral filter characteristics, and it is independent of input pump power and saturable absorber effects. This laser provides an attractive option of controlling the pulse dynamics of a fiber laser with the use of a simple spectral filter.
Der Einsatz von Servicerobotern bei Epidemien und Pandemien
Authors: Bendel Oliver
Published: October 2020

Seit jeher werden Roboter eingesetzt, um gefährliche oder für uns nicht bewältigbare Aufgaben zu erledigen. Sie entschärfen Bomben, transportieren Gefahrenstoffe und arbeiten sich in für uns nicht erreichbare Gebiete vor. Die COVID-19-Pandemie hat gezeigt, dass auch Serviceroboter, die eigentlich nicht für Sonderfälle vorgesehen sind, hilfreiche Dienste bei der Versorgung von Isolierten und bei der Eindämmung von Krankheiten leisten können. Der vorliegende Beitrag stellt vier Typen von Servicerobotern vor. Dann gibt er Beispiele für die Roboternutzung während der Coronakrise im Jahre 2020. Schließlich wird der Frage nachgegangen, in welchem Umfang und in welcher Weise die Robotertypen zusammenarbeiten können und ob man manche von ihnen zu Generalisten weiterentwickeln kann. Zudem werden Geschäftsmodelle und Betriebsmöglichkeiten thematisiert. Der Beitrag zeigt, dass Kohorten von Robotern in Zukunft lebenswichtig sein könnten.
Wissens- und lernorientierte Instandhaltung unter dem Aspekt zunehmender Digitalisierung
Authors: Huber Cornelia , Passath Theresa , Biedermann Hubert
Published: October 2020

Die Digitalisierung bietet Industrieunternehmen eine Vielzahl von Möglichkeiten und Lösungen (z. B. Big Data Analytics, Cloud-Computing, Internet of Things), die mit zunehmenden Anforderungen an das Wissensmanagement verbunden sind. Ein angepasstes Assetmanagement zur Sicherstellung von Markterfolgsfaktoren sind für die Smart Factory unerlässlich. Ein ganzheitliches wertschöpfungsorientiertes Managementkonzept bietet die Lean Smart Maintenance Philosophie, das den geänderten Umfeldbedingungen Rechnung tragend, eine dynamisch anpassbare Instandhaltungsstrategie ermöglicht. Insbesondere die Ressource Wissen gewinnt in Anbetracht einer ständig steigenden Anlagenkomplexität in Form der wissen- und lernorientierten Instandhaltung an Bedeutung, damit zukünftig der Einsatz neuer Technologien nachhaltig wirtschaftlich ist. In diesem Zusammenhang wird nachstehend eine praxisnahe Vorgehensmethodik präsentiert, die die Externalisierung impliziten Wissens durch die Kombination der Wissensbausteine nach Probst mit dem DMAIC-Zyklus unterstützt. Die Digitalisierung induziert geänderte Anforderungen an die Mitarbeiter und Mitarbeiterinnen; geeignete Qualifizierungsmaßnahmen sollten für die bestmögliche Weiterentwicklung der Humanressourcen frühzeitig erkannt und implementiert werden.
Assessing the state of forensic support to criminal investigations in Ghana: A case study in the Greater Accra Region
Authors: Sumara Sulley Yahaya , Quansah Lydia
Published: October 2020

Forensic science applications in criminal investigation are very profound to crime resolution. However, there is a wide gap between the application of specialist skills and public knowledge and awareness of forensic science in criminal investigations and it has generated complex practical problems in justice delivery in Ghana. The study attempts to assess the state of forensic support to criminal investigations by accessing public knowledge and perception of forensic science in Ghana. To this account, an elaborate and tortuous survey was conducted using 200 consented respondents in selected neighborhoods in Accra based on homogeneity, population density, economic or industrial activities, and the nature of crime and police activities. The survey included face to face interviews, questionnaire responding, and random phone calls. The final data which was subjected to a simple linear regression model were analyzed with STATA 13. The study revealed that indeed, forensic science in Ghana has "gone dark" as 165(82.5%) who had a formal education of various levels had very limited knowledge about forensic science and procedures. The majority of the respondents 179(89.5%) had no idea about forensics and for that matter lacked awareness of forensics in Ghana before the research while the state of forensics in Ghana was rated on the scale of good (10.5%), bad (81.5%) and very bad (8%) out of the 200 respondentswiththe respondentlevel of education, perception, knowledge, andawareness of forensic science and support significantly impacting the wellbeing of the research.The findings of this study call for government and respective stakeholders and policymakers of various institutions, and the adversarial system of Ghana to prioritize the need for forensic science. This is to support criminal investigations to assure the Ghanaian citizens of their safety, security, and fundamental Human rights to justice.
ORIENTASI BANGUNAN RUMAH SUSUN MENUJU HUNIAN VERTIKAL YANG EFISIEN ENERGI Studi Kasus Blok A dan B, Rumah Susun Kudu Semarang
Authors: Firmandhani Satriya Wahyu , Pandelaki Edward Endrianto
Published: October 2020

This research responded to environmental issues that arise related to green design as the responsibility of architectural actors. A building is now required to have environmentally friendly values, one of that can be reflected in the energy efficiency of the building. Kudu Flats is one of the towers in the city of Semarang which had several blocks with different orientations. Related to these environmental issues, this study aimed to determine the level of energy efficiency in the Kudu flats with consideration of building orientation, openings and shading devices using quantitative methods based on edge design. This study revealed that flats blocks that have smaller openings in the east-west direction are more energy efficient and rotating the building orientation 15 ° from the wind direction will make the building more energy efficient.
„Ja nie opisuję”. Opis w poglądach estetycznych i praktyce pisarskiej Stanisława Przybyszewskiego
Authors: Wedemann Marek
Published: October 2020

Artykuł podejmuje znany problem złożonych relacji między twórczością Stanisława Przybyszewskiego a naturalizmem, przenosząc go jednak z płaszczyzny stricte światopoglądowej na bardziej poetologiczną. W centrum uwagi umieszcza bowiem spór o opis i opisowość jako te składniki dzieła literackiego (lub malarskiego), które konstytuują obraz świata. Rzecz dotyczy więc styku estetyki z epistemologią.
Kilka uwag o opisie autotematycznym (i nie tylko). Wiersz (Trackless) Andrzeja Sosnowskiego w perspektywie filozofii języka
Authors: Waligóra Agnieszka
Published: October 2020

Artykuł jest próbą zinterpretowania słynnego Wiersza (Trackless) autorstwa Andrzeja Sosnowskiego na podstawie tez filozofów języka (Frege, Searle, Russell). Wywiedzione z wiersza pojęcia śladu i tropu służą interpretacji zjawiska autotematyzmu (który – jak próbuje wskazać autorka – ma strukturę tropiczną). Wskazane problemy (trop, ślad, autotematyzm, filozofia języka) zostają omówione w świetle kategorii opisu, który ujmowany jest jako: 1) podstawowy sposób ujmowania „braku” i „straty”, pojęć istotnych dla projektu poetyckiego omawianego autora; 2) istotna składowa utworu autotematycznego, który – zgodnie z tezami Jonathana Cullera – dzieli się na warstwę opisywaną i opisującą; 3) fundamentalny sposób poznania, zwłaszcza w obliczu suponowanych przez filozofię języka niejasności wiązanych z kategorią nazwy.
Service evaluation and retrospective audit of electronic HEEADSSS (e-HEEADSSS) screening device in paediatric inpatient service in Western Australia
Authors: Saw Chia , Smit Alide , Silva Desiree , Bulsara Max K. , Nguyen Edward Tam Thuong Tran
Published: October 2020

Objectives

The top causes of adolescents’ mortality in Australia and worldwide are mostly preventable and many stem from psychosocial difficulties. The HEEADSSS screening is a widely accepted screening tool in assessing young people’s psychosocial wellbeing. This retrospective audit was done to evaluate the service implementation of an electronic-HEEADSSS (e-HEEADSSS) screening system in a regional hospital’s paediatric in-patient setting in Western Australia. The aim is to examine and compare the uptake rate of conventional HEEADSSS screening in 2018 and e-HEEADSSS screening in 2019, and to examine the relevant outcome and disclosure rate by the young person.

Methods

This retrospective audit (pre-post cross sectional study) is reported using the STROBE guideline. It was done over two different time frames: Pre e-HEEADSSS implementation (September–December 2018) and Post e-HEEADSSS implementation (September–December 2019). Inclusion criteria includes: All paediatric inpatients aged 12–16 years old. Exclusion criteria includes: Admission under other disciplines or clinically unstable/unsuitable patients. The uptake rate of conventional-HEEADSSS (2018) in comparison to e-HEEADSSS screening (2019) was examined. Other relevant data was extracted and analysed.

Results

The sample size pre-implementation was 26 while post-implementation was 24. The uptake rate increased from 12% (conventional-HEEADSSS) to 54% (e-HEEADSSS), a 450% increment with the e-HEEADSSS system implementation (Fisher Exact Test, p=0.005). More than half of young people who completed their e-HEEADSSS screening had concerns/flags which required management by the clinicians. 86% of patients in the e-HEEADSSS group with concerns/flags were acted appropriately by the treating clinicians prior to discharge. The overall disclosure rate of e-HEEADSSS was 93% with highest disclosure rate for ‘Drugs’ domain.

Conclusions

There is significant increase in uptake rate with high disclosure rate using e-HEEADSSS screening device when compared to conventional HEEADSSS screening in the paediatric in-patient setting. The e-HEEADSSS is a better screening tool for in-patient setting and should be implemented widely.
„Odi profanum vulgus et arceo“. Zwei lateinische Oden des Schülers Nietzsche
Authors: Wollek Christian
Published: October 2020

The detailed interpretation and translation of Nietzsche’s early Latin odes clearly show that Horace’s lyric poetry has an exemplary function for the development of Nietzsche’s own poetic language. Even in his later works, such asTwilight of the Idolsand theDionysos-Dithyrambs, Nietzsche’s poetic style and rhetorical strategies remain indebted to his early attempts to emulate classical Latin poetry when he was a pupil at the Pforta boarding school.
Some Recent Work on Nietzsche’s Ethical Thought
Authors: Elgat Guy
Published: October 2020

An important question in Nietzsche studies is whether Nietzsche has an ethics to offer his readers; whether, that is, he has a concept of the good, or the just, or the virtuous that can serve as some sort of an ethical guide. An additional, methodological question is whether, in search of an answer, one should focus on a specific period in his thinking, study the evolution of his thought, or attempt to extract an over-arching view that draws on texts from different stages of his thinking. The three works reviewed concern themselves with Nietzsche’s ethics by each adopting one of these three approaches, supplying us, accordingly, with different results.
Root essential oil ofChrysopogon zizanioidesrelaxes rat isolated thoracic aorta – anex vivoapproach
Authors: Sivakumar Lekha , Chellappan David Raj , Sriramavaratharajan Venkatraman , Murugan Ramar
Published: October 2020

Root ofChrysopogon zizanioides(L.) Roberty has been used in Siddha system of medicine to treat hypertension. The present study was therefore to investigate the vasorelaxation effect of root essential oil ofC. zizanioidesusing rat isolated thoracic aortic rings. Chemical characterization of root essential oil was carried out using Gas Chromatography–Flame Ionization Detector (GC–FID) and Gas Chromatography–Mass Spectrometry (GC–MS). Essential oil nanoemulsion (EONE) was prepared and characterized. Vasorelaxant effect of EONE in endothelium-intact aortic rings precontracted with phenylephrine (PE) (1 µM) or KCl (80 mM) was investigated. Role of Ca2+, nitric oxide and K+channels in precontracted aortic rings were investigated to elucidate the mechanism of action of the essential oil. Further, the role of muscarinic and prostacyclin receptors in EONE induced relaxation was studied. The EONE significantly induced relaxation (Emax77.1 ± 4.87%) in PE precontracted aortic rings. The nitric oxide synthase, and cyclooxygenase inhibitors and potassium channel blockers have not significantly inhibited the vasorelaxation induced by EONE. However, EONE induced relaxation in precontracted endothelium-intact aortic rings was significantly inhibited by muscarinic receptor and calcium channel. The root essential oil ofC. zizanioidespossesses vasorelaxant effect through muscarinic pathway as well as acts as calcium channel blocker.
Common Origin of the Cerebellar Dual Somatotopic Areas Revealed by Tracking Embryonic Purkinje Cell Clusters with Birthdate Tagging
Authors: Tran-Anh Khoa , Zhang Jingyun , Nguyen-Minh Viet Tuan , Fujita Hirofumi , Hirata Tatsumi , Sugihara Izumi
Published: October 2020

One of the notable characteristics of the functional localization in the cerebellar cortex is the dual representation of the body (somatotopy) on its anterior-posterior axis. This somatotopy is conspicuous in the C1/C3 module, which is demarcated as the multiple zebrin-negative and weekly-positive stripes in dual paravermal areas in anterior and posterior lobules within the cerebellar compartments. In this report, we describe the early formation process of the cerebellar compartmentalization, particularly in the C1/C3 module. As developing PCs guide formation of the module-specific proper neuronal circuits in the cerebellum, we hypothesized that the rearrangement of embryonic Purkinje cell (PC) clusters shapes the adult cerebellar compartmentalization. By identifying PC clusters with immunostaining of marker molecules and genetical birthdate-tagging withNeurog2-CreER (G2A) mice, we clarified the three-dimensional spatial organization of the PC clusters and tracked the lineage relationships among the PC clusters from embryonic day 14.5 (E14.5) till E17.5. The number of recognized clusters increased from 9 at E14.5 to 37 at E17.5. Among E14.5 PC clusters, the c-l (central-lateral) cluster which lacked E10.5-born PCs divided into six c-l lineage clusters. They separately migrated underneath other clusters and positioned far apart mediolaterally as well as rostrocaudally by E17.5. They were eventually transformed mainly into multiple separate zebrin-negative and weakly-positive stripes, which together configured the adult C1/C3 module, in the anterior and posterior paravermal lobules. The results indicate that the spatial rearrangement of embryonic PC clusters is involved in forming the dual somatotopic areas in the adult mouse paravermal cerebellar cortex.
The Interaction of Munc18-1 Helix 11 and 12 with the Central Region of the VAMP2 SNARE Motif Is Essential for SNARE Templating and Synaptic Transmission
Authors: André Timon , Classen Jessica , Brenner Philipp , Betts Matthew J. , Dörr Bernhard , Kreye Susanne , Zuidinga Birte , Meijer Marieke , Russell Robert B. , Verhage Matthijs , Söllner Thomas H.
Published: October 2020

Sec1/Munc18 proteins play a key role in initiating the assembly of N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes, the molecular fusion machinery. Employing comparative structure modeling, site specific crosslinking by single amino acid substitutions with the photoactivatable unnatural amino acid p-Benzoyl-phenylalanine (Bpa) and reconstituted vesicle docking/fusion assays, we mapped the binding interface between Munc18-1 and the neuronal v-SNARE VAMP2 with single amino acid resolution. Our results show that helices 11 and 12 of domain 3a in Munc18-1 interact with the VAMP2 SNARE motif covering the region from layers −4 to +5. Residue Q301 in helix 11 plays a pivotal role in VAMP2 binding and template complex formation. A VAMP2 binding deficient mutant, Munc18-1 Q301D, does not stimulate lipid mixing in a reconstituted fusion assay. The neuronal SNARE-organizer Munc13-1, which also binds VAMP2, does not bypass the requirement for the Munc18-1·VAMP2 interaction. Importantly, Munc18-1 Q301D expression inMunc18-1deficient neurons severely reduces synaptic transmission, demonstrating the physiological significance of the Munc18-1·VAMP2 interaction.
KINETICS OF ANTIOXIDANTS DEGRADATION AND QUALITY CHANGES OF CITRON (Citrus medica) FRUIT JUICE CONCENTRATE DURING STORAGE
Authors: Islam Md Zohurul , Dey Pappu , Hoque Md. Mozammel , Monalisa Kamrunnaher
Published: October 2020

The aim of the study was to develop fruit juice concentrate from Citron and its kinetic evaluation during storage at 10 ºC, 25 ºC and 40 ºC respectively, for 12th week. The effect of different temperatures on the quality of the juice concentrate was also investigated. The concentration of ascorbic acid in the juice concentrate was monitored after every week of storage. The results showed that degradation kinetics of ascorbic acid during storage was followed by the first-order kinetics. The degradation rates of ascorbic acid during storage at 10 ° C, 25 °C and 40 °C  were obtained as 2.27 ± 0.24, 2.46 ± 0.31 and 2.56 ± 0.34 1/week  respectively. The higher degradation rate was observed at 40 °C storage temperature. Temperature-dependent rate constants of ascorbic acid of citron juice concentrate was obeyed the Arrhenius relationship with higher R2 values as 0.96.  Total antioxidant degradation was also high at higher storage temperatures. The amount of total phenolic content was decreasing at the first few weeks of storage, but later period of storage it was in gradually increasing trend. The storage study demonsrated that ascorbic acid, total polyphenol and antioxidant activity were not degraded at lower temperature after 12th week.
AUGMENTING THE EFFICIENCY OF SCAFFOLDING IN MEDICAL THERAPIES WITH THE ADVENT OF NANOTECHNOLOGY
Authors: Tomar Pushpa C , Kalra Tanya , Kohli Harisha , Arora Komal
Published: October 2020

The art of manipulating materials on atomic or molecular scales that give rise to nano sized structures and devices is dynamically pioneered and instituted into the world by the name nanotechnology. The field of nanotechnology has ratified its command and is intensifying quickly with its ongoing work in the design, characterization, synthesis, and application of materials and systems by controlling shape and size at nanometer scale. Towards solving the problem of biology and medicine, many efforts have been focused in the direction of the use of nanostructures. This study starts with the main highlights of the types of Nanoscaffolds, surface modification of these scaffolds, applications of Nanoscaffolds in tissue regrowth and terminates with interaction of cells with scaffolds. We have multiple minds all around globe as a result having different perspectives of using these novel technologies in the domain of medical treatment and diagnosis. However, there are many ethics that arose with any new technology amongst supporters and opponents but now is the time to embrace the changes and not been clung to the old ways. So, let us welcome these novel technologies which pave the way for trimming down much of our problems.
Cerámica. La materia protectora
Authors: De-Miguel Eduardo , Fernández-Vivancos Enrique
Published: October 2020

El presente artículo reflexiona sobre la condición material de la arquitectura, entendiendo la materia como el medio de expresión de las ideas y el elemento capaz de transformarlas en obra construida Se centra en el estudio de la cerámica y la muestra como un componente protector que encuentra en su singular capacidad de adaptación formal, funcional y simbólica, la cualidad que le ha permitido contribuir a la solución de nuevos problemas o a proponer creativas formas de emplearla. A través de algunos procedimientos visionarios llevados a cabo con estos materiales desde finales del siglo XIX, basados en las posibilidades de la tecnología, su utilización inteligente y racional, disponibilidad para el reciclaje y puesta en valor de la tradición, se pretende aportar un análisis que ayude a concebir con la misma fuerza innovadora soluciones sostenibles para dar respuesta a los grandes retos y compromisos globales adquiridos
¿De qué substancia está hecha la arquitectura? Contigüidades y serendipias en torno al agua en el proyecto contemporáneo
Authors: Domingo-Santos Juan , Moreno-Álvarez Carmen
Published: October 2020

El texto versa sobre el reencuentro de la creación con la contigüidad universal de pensamiento, materia y forma, y cómo ciertas arquitecturas son concebidas de una substancia única que se transfiere a los elementos que integran la obra. El artículo pone en crisis la condición estrictamente técnica de gran parte de la arquitectura del siglo XX -especialmente del Movimiento Moderno-, con un “ensimismamiento” de la disciplina vista desde la técnica y el repertorio de materiales. Aunque no es posible generalizar y los caminos del proyecto contemporáneo son amplios, se podría hablar de una cierta línea de pensamiento heredera de una contigüidad universal (Ovidio, Fourier, Calvino) presente en ciertas arquitecturas de la historia que establecen una clara diferenciación entre los materiales de construcción y la substancia con la que se concibe la arquitectura. El texto es una reflexión sobre estas cuestiones tomando el agua como argumento para la creación en la arquitectónica.
Adrenal Metastases as Sanctuary Sites in Advanced Renal Cancer
Authors: Vaishampayan, MD Ulka , Shah Harsh , Asad Mohammad F , Shi Dongping , Dickow Brenda , Suisham Stacey , Domina Jason , Cher Michael L. , Samantray Julie , Aoun Hussein D.
Published: October 2020

Involvement of adrenal gland in kidney cancer represents a unique site of metastasis with a distinct clinical course. The cases are typically resistant to immune therapy and need local therapy management. A case series of patients with adrenal metastases was reviewed to highlight the nuances of clinical course and therapy. We reviewed renal cancer carcinoma (RCC) cases with adrenal metastases at Karmanos Cancer Center, Detroit MI. Medical records were reviewed to collect relevant case information. Next-generation sequencing, tumor mutation burden testing, and programmed death ligand bio-markers were evaluated in five cases. Twelve cases were reviewed; all were males with a median age of 49.5 years. Three patients presented with adrenal metastases only and were treated with local therapy. Three received interleukin-2 (IL-2). One patient relapsed with bilateral adrenal lesions after 11 years of remission, post-IL-2 therapy. Five cases received immune checkpoint inhibitor (ICI) and one received antivascular therapy. ICI therapy was followed by ablation of residual adrenal metastases in three patients. Genomic profiling was available in five cases. All were BAP1 and PD-L1 negative.Patho-genic mutations in PBRM1, SETD2, and VHL were noted. All patients with residual adrenal metastases responded to antivascular therapies or to local ablation. One patient died 17 years after diagnosis and 11 patients are alive at a median follow-up of 9.5 years. Adrenal metastases in RCC have a distinct clinical course. They can represent a sanctuary site of relapse/residual disease following treatment with immune therapy. Management with local therapy can induce durable remissions. Systemic management with antivascular therapies also demonstrated favorable responses. Further investigation should focus on the unique clinical course and optimal management of adrenal metastases in kidney cancer.
Between Full Endorsement and Blind Deference
Authors: Goodin Robert E.
Published: October 2020

In Democracy Without Shortcuts, Cristina Lafont advocates for the ‘full endorsement’ of laws and policies by all subject to them instead of ‘blind deference’ to the judgement of others. But if ‘full endorsement’ means anything like ‘complete consensus’ it is an unattainable ideal, and there are many perfectly reasonable ways short of ‘blind deference’ by which we take into account inputs from others when arriving at our own decisions. This article is devoted to exploring that middle ground—on which Lafont herself seems to agree we must always be operating, based on a closer reading of her book. The key to avoiding ‘blind deference’, I argue, is exercising your own independent judgement in deciding when and how far to defer to which others.
Fruit and seed micromorphology of the genus Iberis L. (Brassicaceae) in Turkey and its utility in taxonomic delimitation
Authors: Yilmaz-Çitak Burcu , Dural Hüseyin
Published: October 2020

Background: This paper investigates whether the fruit and seed micromorphology of eight Turkish Iberis (Brassicaceae) species can be used as a further aid in their taxonomic delimitation.
Questions: Are the micro-morphological characters of the fruits and seeds of Iberis useful to support the taxonomic delimitation of its species?
Studied species / data description /Mathematical model: The eight species of Iberis present in Turkey were examined. The fruit and seed characteristics were obtained and statistical analysis was performed using UPGMA.
Study site and dates: Fifteen localities in Turkey, from 2015 to 2019.
Methods: Samples of fruit and seed of eight species of Iberis were collected, stored, and later measured and described with aid of light and scanning electron microscopies.
Results: All eight species had different fruit and seed characters; particularly differing from each other with respect to fruit and seed size, seed shape and seed ornamentation. Two fruit ornamentation types were evident, smooth and striated. The seed coat surface were separated into three types: reticulate, reticulate-rugose and reticulate-papillate, being reticulate the most common. Further differences were noted for the seed surface epidermal structures, notably species had rectangular, tetragonal, or pentagonal patterning. An identification key was constructed based on a similarity analysis.
Conclusions: Fruit morphology, seed dimensions, colour, and epidermal cell patterning are useful microcharacters that enabled species-level determinations in the Iberis species sampled.