bluuebunny/crossref_metadata_2025 huggingface dataset:
Hemangioma of the face and neck with phleboliths
Authors: Valerio Claudia Scigliano , Xambre Pedro Augusto Oliveira Santos , Vidigal Bruno César Ladeira , Rocha Beatriz de Carvalho Silva , Manzi Flávio Ricardo
Published: January 2018

Hemangiomas found in the head and neck regions can cause functional and aesthetic complications. The therapeutic approach to this condition presents both challenges and risks, mainly when surgical procedures must be performed due to the risk of hemorrhaging. In this context, the need for tooth extraction can represent a factor of great concern. The present study describes the case of extensive cavernous hemangioma, associated with a large quantity of phleboliths, affecting the orofacial and neck region in an adult woman. Embolization and controls were performed as a means of surgical treatment.
Analysis of profiles of patients on oral anticoagulants undergoing dental extraction - A retrospective study
Authors: Daroit Natália Batista , Festugatto Fábio Luis , Beltrame Luiz Felipe , Maciel Júlio César Córdova , Rados Pantelis Varvaki
Published: January 2018

Introduction: Many oral surgeons, in clinical practice, face the challenge of management of patients under anticoagulants treatment. The main reason for this concern is the post- operative problems. Objective: The objective is to demonstrate the profiles of patients on oral anticoagulants, who underwent exodontia and did not have complications. Material and Methods: This review was performed using the records of all cases of Special Care Dental Ambulatory during a period of two years. Results: Records of a total of 60 patients, 82 procedures, and 145 extracted teeth were found. The anticoagulant utilized for the sample was warfarin, the mean INR was 2.47 (SD ± 0.53), the majority of teeth extracted was monoradicular was extracted one/time. Conclusion: Can be inferred that is safe to perform dento-alveolar surgeries in anticoagulants patients since additional care measures such as INR monitoring, minimally traumatic technique, and local hemostasis are adopted. This research clarifies some aspects related to routinely surgical procedures in patients under oral anticoagulant therapy.
Histological analysis of a clinical case of central giant cell lesion treated with triamcinolone
Authors: Neri Júlia dos Santos Vianna , Fortuna Tila , Couto Milena , Marchionni Antônio Márcio Teixeira , Reis Sílvia Regina de Almeida , Medrado Alena Ribeiro Alves Peixoto
Published: January 2018

Introduction: Central giant cell lesion (CGCL) is an osteolytic lesion mainly found in gnathic bones of children and young adults. It is a benign lesion with variable clinical and radiographic behavior but it may be aggressive. Intralesional corticoid application has been proposed as an alternative and complementary procedure to radical surgical treatment, to minimize functional and aesthetic damage. Objectives: This paper aims to report a case of a pediatric patient with CGCL of the jaw, which was treated withconservative treat- ment of two intralesional applications of triamcinolone and discuss if there is an ideal waiting period between nonoperative treatment and the need for surgical intervention. Methods: This report shows a quantitative analysis of histological alterations induced by intralesional infiltrations of triamcinolone into a clinical resistant CGCL. A 7-year-old patient was submitted to a conservative treatment of two intralesional applications of triamcinolone into a mandible CGCL. Results and Conclusion: Histological evaluation showed reduction in the number of blood vessels and of giant multinucleated cells, besi- de an increased collagen production. The triamcinolone induced histological alterations seem to interfere in the clinical behavior of the lesion thus, recommending a less radical surgical treatment.
Fine needle aspiration biopsy of mandible: an effective alternative to conventional biopsy for the differential diagnosis between metastasis and osteonecrosis in oncologic patients treated with bisphosphates - Case report
Authors: Baldi Débora Silva , Pinto Fabiano Saggioro , Ferrari Tatiane Cristina , Ramos Lara Maria Alencar , Macedo Leandro Dorigan de
Published: January 2018

Bisphosphonates are the drugs of choice for the prevention and treatment of bone metastases of breast cancer, especially in more advanced cases. Osteonecrosis of the jaw (BRONJ) is the most common, debilitating complication of the use of this drug, caused mainly by bone manipulation. Because of this, the indication for biopsy for differential diagnosis is critical in cases of radiographic findings without mandibular exposure, and less invasive diagnostic methods have been discussed in the literature. The objective of this study was to describe a case of differential diagnosis of mandibular metastasis of breast cancer and BRONJ by fine needle aspiration (FNA). A 67-year-old woman was referred to the Dentistry and Stomatology Service of Ribeirao Preto General Hospital, Brazil, in January 2015, for investigation of pain followed by paresthesia in the lower lip. The patient had a history of mixed breast carcinoma in 1999, recurrent in 2010, treated with chemotherapy and Zometa from 2010 to 2013. Although no significant alterations were detected at clinical examination, the CT scan revealed osteolytic lesions involving the anterior and posterior right jaw. Because of the risk of bone necrosis after biopsy, FNA was chosen as the diagnostic method. Cytology confirmed metastasis of breast cancer and the patient had no complications in the puncture area. FNA was shown to be a viable, safe option for differential diagnosis between BRONJ and mandibular bone metastasis.
Oral sarcoid granuloma associated with discoid lupus erythematosus
Authors: Verde Maria Elisa Quezado Lima , Nascimento Isabelly Vidal do , Dantas Thinali Sousa , Sousa Fabrício Bitu , Alves Ana Paula Negreiros Nunes , Mota Mário Rogério Lima
Published: January 2018

Sarcoidosis is a chronic systemic disorder characterized by the formation of non-caseous granulomas. Oral manifestations are less frequent and may present as submucosal nodules. Because of its heterogeneity and similarity to other diseases, the diagnosis becomes chal- lenging. Objective: To report a case of oral sarcoid granuloma in a patient with discoid lupus erythematosus. Case report: A female patient, complaining of a three-month swelling of the lower lip. Previous nasal lesion with a diagnosis of granulomatous dermatitis was also reported. The labial biopsy was performed, showing sarcoid granulomas. Other complementary exams were requested to verify systemic involvement by sarcoidosis. The lesion spontaneously regressed, and an 18-month follow-up showed no recurrence. Due to the absence of a probable etiological factor associated with the lesion triggering, the histological and clinical evidences, a probable coexistence of discoid lupus erythematosus and sarcoid reaction or early-stage sarcoidosis was suggested. Conclusion: This rare case highlights the possibility of association between lupus and sarcoid granulomas, emphasizing the need for the dental surgeon to contemplate the differential diagnosis of sarcoidosis or sarcoid reaction in patients with lupus who present oral lesions similar to those of the present case, since the oral lesions of lupus are polymorphic and have a varying presentation.
Frequency and histoclinic pathology of malignant and potentially malignant disorders of oral cavity in Chile
Authors: Aitken-Saavedra Juan Pablo , Valdivia Angélica Diaz , Adorno-Farias Daniela , Maturana-Ramirez Andrea , Tarquinio Sandra Chaves , Silva Karine Duarte da , Fernandez-Ramires Ricardo
Published: January 2018

Introduction: Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer worldwide. Oral potentially malignant disorder (OPMD) represents a tissue where is more probably to occur a cancer in comparison with the apparently normal counterpart. Objective the purpose of this study was to determine the frequency and histoclinicpa- thology of these diseases in a Chilean population. This was a descriptive retrospective study. Material and Methods: Patients diagnosed with DPMO, OSCC and verrucous carcinoma (VC) treated in the Oral Medicine Clinic of University of Chile between 2005 and 2015 were selected, being revised the medical records and histopathological diagnoses. Results: From a sample of 241 patients, 60% were women and the mean age was 58 years. The prevalence of DPMO was 15%. The most prevalent of them was oral lichen planus (45%) follow by a 36% of leucoplakias, 16% of actinic cheilitis and 3% of erythroplakias. OSCC and VC accounted to 3.4% and 0.5% of the sample, respectively. The disease-free survival in 5 years for patients with OSCC was 39%. Conclusions: The results were similar to those reported by national and international studies must survival found was lower than reported.
Pathological pigmentation of the skin and palate caused by continuous use of chloroquine
Authors: Ferrazzo Kívia Linhares , Payeras Márcia Rodrigues , Surkamp Patrícia , Danesi Cristiane Cademartori
Published: January 2018

Introduction: Chloroquine diphosphate is an antimalarial drug commonly used in the treatment of autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. Chronic use of this drug may cause toxicity and lead to irreversible visual loss. Objective: To report a case of pathological pigmentation of the skin and oral mucosa caused by the use of chloroquine diphosphate. Case report: A 40-year-old female patient used daily doses of chloroquine (250 mg) to treat rheumatoid arthritis. After using this antimalarial drug for two years, the patient exhibited pathological pigmentations in the hard palate and skin of the lower limbs. To prevent retinal damage, given the toxicity observed in the skin and mucous membranes, the medical team replaced this antimalarial drug. Conclusion: Pathological pigmentation is a sign of drug toxicity and may serve as a warning for health professionals in order to prevent macular diseases caused by an- timalarial agents. We emphasize the importance of dental surgeons for the differential diagnosis of pathological pigmentation of the oral mucosa, as well as the importance of multidisciplinary work involving other health sectors to prevent the onset or worsening of clinical problems in these patients.
Simultaneous oral, bone, and lung manifestations of tuberculosis
Authors: Pinto Antonione Santos Bezerra , Furuse Cristiane , Soares Haroldo Arid , Thomaz Luiz Alexandre , Teixeira Lucas Novaes
Published: January 2018

Tuberculosis (TB) is a chronic granulomatous disease caused by Mycobacterium tubercu- losis, which is transmitted by saliva droplets from patients with active pulmonary disease to persons in close contact with those infected. TB remains a leading cause of morbidity and mortality in developing countries, including Brazil. This disease primarily occurs in the lungs; however, other organs can be affected. Cervical tuberculous lymphadenitis or scrofula is the commonest form of extrapulmonary TB, particularly in immunocompro- mised patients. In the stomatognathic system, the tongue is the site most often affected by TB, whereas bone is rarely affected. The diagnosis of the active form of TB is made based mainly on clinical and radiographic findings, histopathologic features and sputum culture for M. tuberculosis, while the latent form of TB can be detected by tuberculin skin test or an interferon-γ release assay. The present article aimed to report a case of TB occurring concurrently in the oral cavity, bone and lungs.
Global frequency of benign and malignant odontogenic tumors according to the 2005 WHO classification
Authors: Silva Leorik Pereira da , Macedo Rômulo Augusto de Paiva , Serpa Marianna Sampaio , Sobral Ana Paula Veras , Souza Lélia Batista de
Published: January 2018

Odontogenic tumors are a heterogeneous group of lesions with variable clinical behavior. This manuscript aimed to determine the global frequency and distribution of OT based on the 2005 WHO classification. The manuscript performed a systematic search conduc- ted in only one database (PubMed/Medline). We identified 8,658 articles, of which 495 articles were evaluated. After applying the inclusion and exclusion criteria, 42 papers were selected. Summed up, a total of 13,490 cases of OT were diagnosed. Most cases were found in Asia (n=6,472) and North America (n=2,599). Keratocystic odontogenic tumor (KCOT) (32.1%) was the most frequent neoplasm, followed by ameloblastoma (AMB) (30.6%) and odontoma (ODO) (17.3%). Malignant tumors were uncommon, accounting for 4.7% of all tumors. Of those, malignant ameloblastoma (n=184) and ameloblastic car- cinoma (n=115) were the most common tumors. Overall, OT were more prevalent in men (n=4,896), with a male:female ratio of 1.2:1. The age ranged from 1 to 92 years; however most tumors occurred between the second and fourth decades of life. The mandible was the most common anatomical site, with a mandible:maxilla ratio of 2.8:1. The prevalence profile of OT shows a geographical variation; moreover, studies based on prior WHO classifications present a different incidence and frequency. The 2005 WHO classification of OT altered the distribution of these lesions and possibly made KCOT the most common OT observed worldwide.
“Bildung”: concepto, evolución e influjo en la pedagogía occidental desde una perspectiva histórica y actual
Authors: Sianes-Bautista Alicia
Published: January 2018

Alemania constituye un reconocido “país laboratorio” cuyo influjo clave en el pensamiento y la pedagogía contemporáneos ha sido reconocido unánimemente por los más reputados comparatistas académicos actuales. Especial influjo en la pedagogía occidental ha suscitado el concepto de Bildung, el cual, incardinado en el movimiento neohumanista alemán del siglo XVIII, es un concepto acuñado y desarrollado por Humboldt con ricas y múltiples acepciones, cuyo análisis se revela necesario a fin de desentrañar toda la riqueza de matices e implicaciones que su proyección es susceptible de verter en el ámbito educativo. Interesa para el corpus teórico de la disciplina pedagógica tener presente la relevancia educativa sin precedentes de este concepto alemán que en este artículo tomamos como objeto de estudio, y analizar su etimología y su significado, así como el influjo real de este término en la pedagogía occidental, no sólo desde un punto de vista histórico, sino analizando su impacto en el siglo XXI. A fin de llevar esto a cabo de forma eficaz, elegimos una metodología de carácter cualitativo, basada principalmente en el análisis de contenido mediante una minuciosa revisión de la literatura especializada sobre la temática objeto de estudio. En los resultados obtenidos quedan recogidos, entre otros, el origen etimológico de Bildung, además de su desarrollo conceptual a la vez que educativo a lo largo de la historia hasta llegar a confluir en el actual estado de la cuestión. En conclusión, se pone de manifiesto que dicho concepto ha sido tomado como un elemento singular precedente de multiplicidad de corrientes educativas y formativas no únicamente en la pedagogía occidental europea sino incluso también en la angloamericana, habiendo evolucionado hasta llegar incluso a concebirse como un elemento facilitador de los procesos educativos actuales, los cuales se encuentran inevitablemente enmarcados en la era de las TIC y la web 2.0
Textos y paratextos de las poetas recogidas en la revista Verbo (1946-1963).
Authors: Candel Vila Xelo
Published: January 2018

En este trabajo analizo los poemas y las colaboraciones críticas de las poetas mujeres que colaboraron en la revista Verbo desde 1946 hasta 1963 para constatar que, pese al contexto ideológico y político hostil que no les permitía legitimar su voz ni como mujeres ni como escritoras, al menos en esta revista tuvieron una representación digna de ser mencionada.
Manage Water Quality to Control Lead in Drinking Water
Authors: Brandhuber Philip
Published: January 2018

Water utilities can develop an effective lead corrosion control strategy by controlling water quality.
Att läsa olika typer av texter – finns det lätta och svåra?
Authors: Wengelin Åsa
Published: January 2018

Vad vet vi om läsprocessen som kognitiv process? Hur kan vi studera hur läsprocessen går till i olika typer av texter och vad kan det säga oss om texters svårighet i allmänhet och juridiska i synnerhet? I den här presentationen kommer jag visa hur man med hjälp ögonrörelsestudier kan undersöka läsprocessen och diskutera den i relation till svårighetsgraden i olika texter – juridiska såväl som andra.
Forord
Authors: Jarvad Pia , Mørch Ida Elisabeth
Published: January 2018

Der findes ikke resumé til denne artikel.
Klarspråksgevinstar av samlivet mellom bokmål og nynorsk
Authors: Breivega Ola I.
Published: January 2018

Der findes ikke resumé til denne artikel.
La narrativa digital en el MIDE. Caso de estudio: Sotos, un multimedia interactivo de Fred Adam
Authors: AlcalÃ¡ Mellado JosÃ© RamÃ³n
Published: January 2018

A comienzos de la dÃ©cada de los noventa del siglo pasado, con la comercializaciÃ³n de los primeros programas infogrÃ¡ficos para la producciÃ³n de arte digital, surgen las primeras propuestas creativas que renuevan las formas narrativas clÃ¡sicas. El Museo Internacional de ElectrografÃ­a de Cuenca, a travÃ©s de su programa de artistas residentes y su apertura a nuevas propuestas, acogiÃ³ durante la Ã©poca incipiente del arte digital a artistas de todo el mundo que experimentaron con estos nuevos medios. Uno de los primeros que visitÃ³ el MIDE fue el artista francÃ©s Fred Adam (por aquel entonces todavÃ­a alumno de la Ãcole de Beaux Arts de Nantes), el cual, durante su estancia, realizÃ³ innumerables investigaciones dentro de este campo creativo. Una de las que obtuvo mayor repercusiÃ³n fue la que se centrÃ³ en el desarrollo de narraciones digitales en multimedia interactivo.

Lamentablemente, todavÃ­a hoy, casi treinta aÃ±os despuÃ©s, esas pioneras creaciones de arte digital no solo no tienen su propio relato historiogrÃ¡fico que las ponga en valor y las contextualice entre las prÃ¡cticas artÃ­sticas del periodo entre siglos, sino que, debido a la obsolescencia de la tecnologÃ­a con que fueron creadas, ya no son accesibles. En este trabajo se persigue la puesta en valor de algunas de estas obras pioneras, construyendo su relato a la par que recuperarlas y preservarlas, y asÃ­ actualizar sus lenguajes para que vuelvan a ser accesibles. Solo a travÃ©s de este compromiso institucional y personal con la historia podremos recuperar, divulgar y dar acceso al inmenso patrimonio artÃ­stico que generÃ³ y sigue generando el arte que usa o tiene como referencia los nuevos medios. El presente trabajo desarrolla esta investigaciÃ³n al amparo de la nueva disciplina denominada Media Art Histories, la cual emplea como una de sus herramientas metodolÃ³gicas de normativizaciÃ³n la Media Archaeology.
Muntadas: una metodologÃ­a de investigaciÃ³n artÃ­stica en movimiento
Authors: Santa Olalla Pablo
Published: January 2018

Este artÃ­culo aborda, desde el estudio de caso del artista espaÃ±ol Antoni Muntadas, la relaciÃ³n entre movilidad e investigaciÃ³n artÃ­stica. Partiendo del contexto de movilidad expandida de la Jet Age, se analizan las relaciones del contexto sociopolÃ­tico y cultural con el campo artÃ­stico y, especÃ­ficamente, con el arte conceptualista. El arte conceptual es el marco de apariciÃ³n de un agente artÃ­stico especÃ­fico, el agente-viajero, al cual se puede asociar la figura de Muntadas. A travÃ©s de una genealogÃ­a de proyectos de este artista, se observa la evoluciÃ³n de su prÃ¡ctica investigativa paradigmÃ¡tica, que no instrumentaliza ni tematiza el viaje, sino que lo incluye estructuralmente a travÃ©s de mecanismos como la serialidad, el trabajo en red y la cooperaciÃ³n profesional.
Claves para tomar posiciÃ³n en los debates sobre investigaciÃ³n artÃ­stica: conflictos y retos de un saber mÃºltiple, cambiante y cuestionador. Contexto espaÃ±ol (1978-2017)
Authors: MarÃ­n GarcÃ­a Teresa
Published: January 2018

La situaciÃ³n actual de la investigaciÃ³n artÃ­stica sigue planteando mÃºltiples conflictos y debates que constatan los desfases de las Ãºltimas dÃ©cadas entre las estrategias de las polÃ­ticas universitarias y la tozuda realidad de la prÃ¡ctica artÃ­stica e investigadora. Con el fin de reubicar posiciones ante estos conflictos y los retos actuales, se plantea una relectura situada de los debates sobre investigaciÃ³n artÃ­stica, en el contexto espaÃ±ol y desde 1978 (cuando las enseÃ±anzas artÃ­sticas se incorporaron al sistema universitario espaÃ±ol) hasta la actualidad. Se propone la visualizaciÃ³n de una lÃ­nea de tiempo para situar los vÃ­nculos entre las polÃ­ticas universitarias y algunos debates relevantes, a travÃ©s de eventos y publicaciones de este periodo. A partir de estos datos, se seÃ±alan algunos de los aspectos clave que identifican los conflictos mÃ¡s relevantes y recurrentes en la investigaciÃ³n artÃ­stica, sobre cuestiones epistemolÃ³gicas (objeto de investigaciÃ³n, terminologÃ­a y metodologÃ­a) y acerca de sus polÃ©micos criterios de evaluaciÃ³n y financiaciÃ³n (vinculados al reconocimiento de los formatos y circuitos de difusiÃ³n, temporalidades, filiaciÃ³n a instituciones, etc.), asÃ­ como otros asuntos que se han considerado secundarios o marginales (como las condiciones laborales de los investigadores, la precariedad del sector artÃ­stico y de la investigaciÃ³n en humanidades o la privatizaciÃ³n y mercantilizaciÃ³n del conocimiento y la cultura). Para finalizar se proponen algunas cuestiones a considerar para tomar posiciÃ³n ante los retos actuales, que deberÃ­an considerar la naturaleza mÃºltiple, cambiante y cuestionadora del saber artÃ­stico.
Embodied and Situated Aesthetics; An enactive approach to a cognitive notion of aesthetics
Authors: Arteaga Alex
Published: January 2018

This text presents a first attempt to specify the cognitive function of aesthetics or, to put it in more radical terms, to define aesthetics as a variety of cognition . Due to the inaugural character of this essayâalthough it is rooted in my former work, it initiates a new research environmentâit merely outlines key ideas in this regard. It maps out a territory which begins to emerge through the landmarks that delineate it. Accordingly, this text does not include detailed argumentations about the proposed ideas. It simply defines the infrastructure of a conceptual construction that will be enabled and precisely realized in the coming years. This endeavor is framed by the so-called theories of embodied and situated cognition and more specifically the enactive approach. According to the first, cognition takes place due to two necessary conditions: the activities of bodiesâbiological realized organismsâand their entanglement with their surroundings. Cognition thus cannot occur on the basis of an ideal entityâe.g. a âpure mindââin a vacuum or âneutral container.â The enactive approach specifies these basic conditions, defining the body as an autonomous system and its involvement with the environment as structural coupling. Furthermore, this cognitive approach explains the relationships between living units and their surroundings in terms of co-emergence: a dynamic and complex system of mutual determination between enabling conditions and emerging qualities.
Robust model-based analysis of single-particle tracking experiments with Spot-On
Authors: Hansen Anders S , Woringer Maxime , Grimm Jonathan B , Lavis Luke D , Tjian Robert , Darzacq Xavier
Published: January 2018

Single-particle tracking (SPT) has become an important method to bridge biochemistry and cell biology since it allows direct observation of protein binding and diffusion dynamics in live cells. However, accurately inferring information from SPT studies is challenging due to biases in both data analysis and experimental design. To address analysis bias, we introduce ‘Spot-On’, an intuitive web-interface. Spot-On implements a kinetic modeling framework that accounts for known biases, including molecules moving out-of-focus, and robustly infers diffusion constants and subpopulations from pooled single-molecule trajectories. To minimize inherent experimental biases, we implement and validate stroboscopic photo-activation SPT (spaSPT), which minimizes motion-blur bias and tracking errors. We validate Spot-On using experimentally realistic simulations and show that Spot-On outperforms other methods. We then apply Spot-On to spaSPT data from live mammalian cells spanning a wide range of nuclear dynamics and demonstrate that Spot-On consistently and robustly infers subpopulation fractions and diffusion constants.
Retracted Publications in Mental Health Literature: Discovery across Bibliographic Platforms
Authors: Bakker Caitlin , Riegelman Amy
Published: January 2018

INTRODUCTION Retractions are a mechanism by which science corrects itself, withdrawing statements or claims that have proven to be erroneous. However, this requires that such corrections be displayed clearly and consistently. This paper considers how retracted publications in the mental health literature are represented across different platforms. METHODS Using Retraction Watch, we identified 144 retracted articles in the mental health field. We looked across seven platforms to determine the consistency and clarity of the retracted status of these publications. RESULTS Of the 812 records for retracted publications, 40.0% (n=325) did not indicate that the paper had been retracted. Of available PDFs, 26.3% (53/201) did not indicate that the paper had been retracted. Of the 144 articles studied, only 10 were represented as being retracted across all resources through which they were available. DISCUSSION Retracted publications in this sample were inconsistently represented across library resources. While technical solutions, such as Crossmark by Crossref, may help mitigate these challenges, the inconsistent display of retractions has implications for education and outreach. CONCLUSION Our study found that the retractions in our sample were not clearly and consistently represented across sources. Libraries, which provide access to and training in these resources, have a responsibility to raise awareness of these inconsistencies and to advocate for more timely and accurate metadata.
What’s in a Name? Exploring identity in the field of library journal publishing
Authors: Whyte Appleby Jacqueline , Hatherill Jeanette , Kosavic Andrea , Meijer-Kline Karen
Published: January 2018

INTRODUCTION This paper explores the variability in self-identifying practices of academic libraries engaged in journal publishing and hosting activities. We were interested in how libraries characterized their efforts in this area and looked at whether there is an unspoken threshold for differentiation with respect to publishing-support naming conventions. METHODS Using the Library Publishing Directory, in-depth interviews, and a more widely circulated follow-up survey, the research team examined service offerings, divisions of responsibility, funding, terminology, and semantic associations within publishing, both as an active practice and as an advertised service. RESULTS AND DISCUSSION We aimed to tease out whether there was any sort of tipping point, or inferred rules, around when an institution chose to call the activity either publishing or hosting. We found no particular service, set of services, funding structure, or division of labor that obviously influenced the use of a particular term. Rather than noting a divide between publishing and hosting, participants spoke of both a spectrum and a tiering of work and support, though all emphasized that these models did not describe the quality of the work produced. This paper also discusses how use of the term library publishing creates additional ambiguity in naming practices, and considers some implications for library staff newly immersed in scholarly publishing work.
Assessment of pharmacists' self-reported preparedness to provide pharmacotherapy services to individuals with psychiatric disorders
Authors: German Alexander , Johnson Laura , Ybarra Georgina , Warholak Terri
Published: January 2018

Introduction:

The purpose of this study was to compare pharmacists' level of training and/or experience in psychiatric pharmacy to (1) their self-perceived preparedness to provide pharmacotherapy services to individuals with psychiatric disorders and (2) barriers to providing pharmacotherapy services to individuals with psychiatric disorders.

Methods:

This study used data from an Internet-based questionnaire. Respondents were divided into 2 groups: group A completed the Arizona Pharmacy Association's Psychiatric Certificate Program, and/or was board certified in psychiatric pharmacy, and/or was a member of the College of Psychiatric and Neurologic Pharmacists, and/or had completed a psychiatric pharmacy residency; group B had no specialized training and/or experience in psychiatric pharmacy. A Mann-Whitney U test was used to compare the scaled responses for each group.

Results:

Compared with pharmacists without training and/or experience in psychiatry (N = 235), respondents with specialized training and/or experience in psychiatric pharmacy (N = 38) reported more frequent interactions with patients with psychiatric disorders and provided more counseling and drug information, monitoring for adverse drug reactions, screening for treatment issues, and both pharmacologic and nonpharmacologic treatment recommendations (P < .05). Pharmacists trained in psychiatry reported being more prepared to provide all pharmacotherapy services (P < .003), except in addressing nonadherence, utilizing online resources, and providing pharmacotherapy services to patients with attention deficit hyperactivity disorder. They reported fewer barriers to providing pharmacotherapy services (P < .005), except for time to provide services, having a private consultation area, and reimbursement for patient care activities.

Discussion:

This study found that responding pharmacists without psychiatric training/experience may need additional education and training after graduation and that they perceive more barriers in providing services to the population with psychiatric disorders.
Solid State Porous Metal Production: A Review of the Capabilities, Characteristics, and Challenges
Authors: Atwater Mark A. , Guevara Laura N. , Darling Kris A. , Tschopp Mark A.
Published: January 2018

Porous metals have been under development for nearly a century, but commercial adoption remains limited. This development has followed two primary routes: liquid state or solid state processing. Liquid state foaming introduces porosity to a liquid or semi‐solid metal, and solid state foaming introduces porosity to a metal, which is fully solid. Either method may create pores by internal gas pressure or introducing metal around a template directly control porosity. Process optimization and commercial output has been primarily related to liquid state methods, as solid state processing is often more complex, diverse, and with lower throughput. Solid state methods, however, are often more versatile and offer greater control of pore characteristics. Ongoing advancements in solid state foaming have allowed for a wide array of metals and alloys to be made porous and the three‐dimensional structure to be precisely tailored. In general, solid state processing remains limited to niche applications, often with modest dimensions (cm scale). “Traditional” solid state processes are being further refined and extended, and continuing developments to reduce cost, increase output, and control pore characteristics are likely to produce important advancements in coming years. The extensive variability of pore quantity and morphology makes solid state processes suitable, and often preferable, for an assortment of functional and structural applications, with electrodes and biomedical devices being among the most popular in current research. Various techniques for introducing porosity, the way these methods are applied, important considerations, typical outcomes, and current applications are reviewed.
Solid‐State Supercapacitor Fabricated in a Single Woven Textile Layer for E‐Textiles Applications
Authors: Yong Sheng , Owen John , Beeby Stephen
Published: January 2018

This paper presents for the first time a solid‐state supercapacitor fabricated in just a single woven cotton textile layer. The controlled spray coating process enables the depth of the activated carbon electrodes to be precisely controlled from both sides of the textile. This leaves an uncoated region within the cotton textile layer that acts as the separator and also minimizes the effect of the added functional materials on the feel of the textile. The cotton electrode is then vacuum impregnated with the gel electrolyte to ensure good coverage of the electrode by the electrolyte. After drying, the single textile layer supercapacitor has been fully characterized and demonstrates good capacitance and excellent electrochemical cycling stability even after mechanically straining the textile.
Red, Green, and Blue Reflections Enabled in an Electrically Tunable Helical Superstructure
Authors: Hsiao Yu‐Cheng , Yang Zong‐Han , Shen Dong , Lee Wei
Published: January 2018

Materials with tunable optical properties in the visible spectrum are intriguingly important in science and technology. Such desired tunability can be conveniently accomplished by controlling optical materials with electric field. Now an organic film of self‐organized helical superstructure producing electrically tunable reflection of visible light is introduced in this work. The composite is a dual‐frequency thermosensitive cholesteric (DFTC) material consisting of a liquid crystal host doped with a binary chiral‐dopant mixture including a thermosensitive chiral switch. The red, green, and blue reflections in the DFTC film can be obtained by varying the frequencies of a 45 Vrmsapplied voltage to induce dielectric heating. The resulting variation in temperature and, in turn, in helical pitch length, enables various wavelengths of reflection to render full‐color display in a single film without the need of film stacking. As far as it is known, this is the first work to demonstrate broad electrical tuning of cholesteric reflection in red, green, and blue.
Violence in paradise: Cranial trauma in the prehispanic population of Gran Canaria (Canary Islands)
Authors: Delgado‐Darias Teresa , Alberto‐Barroso Verónica , Velasco‐Vázquez Javier
Published: January 2018

Objectives

This paper addresses the prevalence and pattern of physical violence in the prehispanic society of Gran Canaria and discusses its link with the social structure and insular context in which that people lived.

Materials and Methods

347 prehispanic crania from Guayadeque Ravine (575–1415 AD) have been examined in order to determine the frequency, types, location, and timing of trauma.

Results

Craniofacial injuries are present in 27.4% of the crania examined. Only 2% display perimortem trauma. Most of the injuries (84.3%) correspond to depressed blunt force trauma, with an ellipsoidal or circular shape. Most of these are in the anterior aspect of the cranium. Males are significantly more affected than females.

Discussion

The aboriginal population of Gran Canaria show a high frequency of traumatic injuries to the skull compared to other archaeological groups. Their frequent location in the anterior aspect suggests regular face‐to‐face confrontations. However, the lethal injuries typically occurring in large‐scale combat are scarce. Practices such as ritualized combat, mentioned in ethnohistorical sources, would help to channel and mitigate inter‐group conflict. The predominance of depressed blunt force trauma is in accordance with the weapons used by those populations: hand‐thrown stones, clubs and sticks. The higher frequency in males indicates that they took part in direct violence more than females did. The hierarchical organization of their society may have led to frequent situations of conflict. The insular nature of a territory barely 1,500 m2 in size was a determining factor in competition for access to food resources, especially at times of climate crises or population growth.
A Highly Stable Copper‐Based Catalyst for Clarifying the Catalytic Roles of Cu0 and Cu+ Species in Methanol Dehydrogenation
Authors: Yang Huanhuan , Chen Yanyan , Cui Xiaojing , Wang Guofu , Cen Youliang , Deng Tiansheng , Yan Wenjun , Gao Jie , Zhu Shanhui , Olsbye Unni , Wang Jianguo , Fan Weibin
Published: January 2018

Identification of the active copper species, and further illustration of the catalytic mechanism of Cu‐based catalysts is still a challenge because of the mobility and evolution of Cu0 and Cu+ species in the reaction process. Thus, an unprecedentedly stable Cu‐based catalyst was prepared by uniformly embedding Cu nanoparticles in a mesoporous silica shell allowing clarification of the catalytic roles of Cu0 and Cu+ in the dehydrogenation of methanol to methyl formate by combining isotope‐labeling experiment, in situ spectroscopy, and DFT calculations. It is shown that Cu0 sites promote the cleavage of the O−H bond in methanol and of the C−H bond in the reaction intermediates CH3O and H2COOCH3 which is formed from CH3O and HCHO, whereas Cu+ sites cause rapid decomposition of formaldehyde generated on the Cu0 sites into CO and H2.
Über Oxidationszahl‐Obergrenzen in der Chemie
Authors: Hu Shu‐Xian , Li Wan‐Lu , Lu Jun‐Bo , Bao Junwei Lucas , Yu Haoyu S. , Truhlar Donald G. , Gibson John K. , Marçalo Joaquim , Zhou Mingfei , Riedel Sebastian , Schwarz W. H. Eugen , Li Jun
Published: January 2018

Der Begriff Oxidationszahl (OS) ist auf der Basis des Lewis‐Elektronenpaar‐Bildes definiert, wobei Bindungselektronen dem jeweils elektronegativeren Element zugeordnet werden. Der Begriff ist hilfreich zur “Buchhaltung” der Elektronen, zur Vorhersage von chemischen Trends und zur Planung von Synthesewegen. Experimentelle und quantenchemische Befunde legen eine obere Grenze von etwa +8 für die OS in stabilen (neutralen) chemischen Substanzen unter normalen Bedingungen nahe. OS=+9 wurde für das isolierte [IrO4]+‐Kation in der Gasphase beobachtet. Vorhergesagte OS=+10 für das isolierte [PtO4]2+‐Kation wird hier theoretisch nur für tiefe Temperaturen bestätigt, konnte aber noch nicht experimentell verifiziert werden. Verbindungen mit hoher OS tendieren zur spontanen Reduktion des zentralen Metallatoms unter Oxidation der Liganden, etwa von O−2 unter Bildung von .O−1 und O‐O‐Bindungen, wobei nicht‐Lewis‐konforme Strukturen gebildet werden können.
Selective Detection of 2,4,6‐Trinitrophenol Based on In Situ‐generated Fluorescent Zn2+–Anthracene Ensembles in 80% Aqueous Dimethyl Sulfoxide
Authors: Pandith Anup , Kim Hong‐Seok
Published: January 2018

Novel in situ‐generated highly fluorescent chelated Zn2+–anthracene (Zn2+•P: 1:1) complex detected 2,4,6‐trinitrophenol (TNP) more selectively by a “switch‐off” response with a very high Stern–Volmer quenching constant (Ksv = 3.75 × 106 M−1) at a 1:2 stoichiometry in 80% aqueous DMSO. The selective quenching response that occurred with TNP is due to the effective destruction of the chelated complex by efficient protonation at secondary amines, which created an effective resonance energy transfer (RET) from the anthracene unit to the TNP. Formation of a stable P2+•(TNP)−2 ionic charge‐transfer complex showed that the anthracene monomer band quenching resulted from efficient RET, accompanied by synergistic multiple hydrogen bonding, electron‐rich–electron‐deficient πAn–πTNP interactions, and columbic interactions. An application was demonstrated using the biocompatible ensemble‐coated hydrogel for ultraviolet‐assisted naked eye sensing, and its sensing mechanism was postulated. The lowest detection limit for TNP was 3.01 × 10−10 M in 80% aqueous DMSO.
RNA‐Peptide nanoplexes drug DNA damage pathways in high‐grade serous ovarian tumors
Authors: Dreaden Erik C. , Kong Yi Wen , Quadir Mohiuddin A. , Correa Santiago , Suárez‐López Lucia , Barberio Antonio E. , Hwang Mun Kyung , Shi Aria C. , Oberlton Benjamin , Gallagher Paige N. , Shopsowitz Kevin E. , Elias Kevin M. , Yaffe Michael B. , Hammond Paula T.
Published: January 2018

DNA damaging chemotherapy is a cornerstone of current front‐line treatments for advanced ovarian cancer (OC). Despite the fact that a majority of these patients initially respond to therapy, most will relapse with chemo‐resistant disease; therefore, adjuvant treatments that synergize with DNA‐damaging chemotherapy could improve treatment outcomes and survival in patients with this deadly disease. Here, we report the development of a nanoscale peptide‐nucleic acid complex that facilitates tumor‐specific RNA interference therapy to chemosensitize advanced ovarian tumors to frontline platinum/taxane therapy. We found that the nanoplex‐mediated silencing of the protein kinase, MK2, profoundly sensitized mouse models of high‐grade serous OC to cytotoxic chemotherapy by blocking p38/MK2‐dependent cell cycle checkpoint maintenance. Combined RNAi therapy improved overall survival by 37% compared with platinum/taxane chemotherapy alone and decreased metastatic spread to the lungs without observable toxic side effects. These findings suggest (a) that peptide nanoplexes can serve as safe and effective delivery vectors for siRNA and (b) that combined inhibition of MK2 could improve treatment outcomes in patients currently receiving frontline chemotherapy for advanced OC.
Needle biopsy‐derived myofascial tissue samples are sufficient for quantification of myofibroblast density
Authors: Schleip R. , Wilke J. , Schreiner S. , Wetterslev M. , Klingler W.
Published: January 2018

Quantification of myofibroblasts is a promising method for assessing tissue properties in the field of fascia research. This is commonly performed by immunohistochemistry for α‐smooth muscle actin. However, usually larger tissue samples sizes are required for quantification. The aim of this investigation was to explore whether a microscopic quantification of myofibroblasts can be conducted with fascial tissue samples derived via percutaneous needle biopsy. Fascial tissues were derived via percutaneous needle biopsy from the fascia lata of 11 persons (aged 19–40 years). Following immunohistochemistry, selected fields for photomicroscopic analysis were chosen by a Monte Carlo method based randomization procedure. On these fields, a digital quantification for the relative density of α‐smooth muscle actin was attempted. The newly developed quantification method could successfully be applied in all tissue samples. The median α‐smooth muscle actin density in the selected tissue samples ranged between 0% and 1.7% (median 0%, IQR 0%–0.001%). The applied protocol proved to be workable for the purpose of an estimation of the α‐smooth muscle actin density in fascial tissue samples derived via percutaneous needle biopsy. Since this type of biopsy is less invasive than the commonly performed open muscle biopsy, this offers a new and useful perspective for future histological investigations of fascial tissue properties in living patients. Clin. Anat. 31:368–372, 2018. © 2018 Wiley Periodicals, Inc.
Methodology Development in Directed Evolution: Exploring Options when Applying Triple‐Code Saturation Mutagenesis
Authors: Qu Ge , Lonsdale Richard , Yao Peiyuan , Li Guangyue , Liu Beibei , Reetz Manfred T. , Sun Zhoutong
Published: January 2018

Directed evolution of stereo‐ or regioselective enzymes as catalysts in asymmetric transformations is of particular interest in organic synthesis. Upon evolving these biocatalysts, screening is the bottleneck. To beat the numbers problem most effectively, methods and strategies for building “small but smart” mutant libraries have been developed. Herein, we compared two different strategies regarding the application of triple‐code saturation mutagenesis (TCSM) at multiresidue sites of the Thermoanaerobacter brockii alcohol dehydrogenase by using distinct reduced amino‐acid alphabets. By using the synthetically difficult‐to‐reduce prochiral ketone tetrahydrofuran‐3‐one as a substrate, highly R‐ and S‐selective variants were obtained (92–99 % ee) with minimal screening. The origin of stereoselectivity was provided by molecular dynamics analyses, which is discussed in terms of the Bürgi–Dunitz trajectory.
Antegrade fenestration and re‐entry: A new controlled subintimal technique for chronic total occlusion recanalization
Authors: Carlino Mauro , Azzalini Lorenzo , Mitomo Satoru , Colombo Antonio
Published: January 2018

Objectives

To describe and evaluate the efficacy of a novel antegrade dissection/re‐entry (ADR) technique, called antegrade fenestration and re‐entry (AFR), for chronic total occlusions (CTO) percutaneous coronary intervention (PCI).

Background

The widespread adoption of ADR is limited by several technical, logistic, and financial factors. Therefore, novel ADR techniques are needed.

Methods

AFR consists in creating multiple fenestrations of the dissection flap separating the false and true lumen. This is achieved by advancing a balloon (sized 1:1 with the artery diameter) onto the antegrade wire into the subintimal space, and inflating it at the level of the distal cap. A soft polymer‐jacketed guidewire is then advanced across the fenestrations created by balloon inflation from the subintimal space into the true lumen. Following its theoretical formulation, patients undergoing ADR‐based CTO recanalization at our institution were considered for AFR treatment.

Results

Between November 2015 and October 2017, 279 CTO PCIs were performed. Of those, ADR was utilized in 33 (12%) cases, of whom AFR was used in 6 (18%). In all but one cases, AFR was performed after failed true‐to‐true lumen crossing, while in the remainder it was utilized after extensive subintimal space disruption following alternative ADR techniques. AFR was successful in all six cases and no complications were observed.

Conclusions

We have developed a novel ADR technique which aims at complementing the CTO operator's armamentarium. AFR does not preclude alternative bailout techniques, and is inexpensive and easy to perform. A dedicated study should confirm our findings in a large cohort.