bluuebunny/crossref_metadata_2025 huggingface dataset:
Paste Backfilling Longwall Mining Technology for Thick Coal Seam Extraction under Buildings and above Confined Aquifers: A Case Study
Authors: Wen Peng , Guo Wenbing , Tan Yi , Bai Erhu , Ma Zhibao , Wu Dongtao , Yang Weiqiang
Published: April 2022

Backfill mining is an effective measure to control surface subsidence and restrain floor water inrush. It is an essential part of green mining technology. To solve the problem of confined water in mines under buildings, this study was carried out by combining theoretical analysis, laboratory simulation, and numerical simulation, taking the Liangbei coal mine as the research area. The coal seam floor failure characteristics of traditional longwall caving and paste filling mining methods were compared and analyzed. Based on the relevant mining theory, the key parameters, such as mining thickness and filling rate under the critical state of water inrush, were obtained. Then, the feasibility of backfill mining was expounded, and the surface subsidence of paste backfill mining was predicted and measured on site. The results demonstrated that the longwall caving mining method not only had the risk of water inrush, but also the possibility of step cracks at the surface, with the potential to result in serious damage to buildings. However, the backfill mining method reduced the floor damage depth of the coal seam from 12 m to 7 m, which reduced the water inrush coefficient by 12%, the maximum vertical concentrated stress by 42.1%, and the displacement subsidence value by 78.8%. These parameters correlated negatively with backfill strength. Meanwhile, the maximum subsidence, maximum inclined deformation, and horizontal displacement deformation were estimated as 730 mm, 2.5 mm/m, and 1.1 mm/m, respectively, consistent with the measured values (608 mm, 2.1 mm/m, and 0.9 mm/m, respectively). More relevantly, there were no obvious cracks found in the surface buildings, ensuring the safety of mining above confined water on the working face, and realizing the effective protection of surface buildings.
MicroRNA-134-5p and the Extent of Arterial Occlusive Disease Are Associated with Risk of Future Adverse Cardiac and Cerebral Events in Diabetic Patients Undergoing Carotid Artery Stenting for Symptomatic Carotid Artery Disease
Authors: Badacz Rafał , Przewłocki Tadeusz , Pieniążek Piotr , Rosławiecka Agnieszka , Kleczyński Paweł , Legutko Jacek , Żmudka Krzysztof , Kabłak-Ziembicka Anna
Published: April 2022

There is little known about the prognostic value of serum microRNAs (miRs) in diabetic patients with symptomatic internal carotid artery disease (ICAS) who underwent stent supported angioplasty (PTA) for ICAS. The present study aimed to investigate expression levels of selected miRs for future major adverse cardiac and cerebral events (MACCE) as a marker in diabetic patients following ICAS-PTA. The expression levels of 11 chosen circulating serum miRs were compared in 37 diabetic patients with symptomatic ICAS and 64 control group patients with symptomatic ICAS, but free of diabetes. The prospective median follow-up of 84 months was performed for cardiovascular outcomes. Diabetic patients, as compared to control subjects, did not differ with respect to age (p = 0.159), distribution of gender (p = 0.375), hypertension (p = 0.872), hyperlipidemia (p = 0.203), smoking (p = 0.115), coronary heart disease (p = 0.182), lower extremities arterial disease (LEAD, p = 0.731), and miRs expressions except from lower miR-16-5p (p < 0.001). During the follow-up period, MACCE occurred in 16 (43.2%) diabetic and 26 (40.6%) non-diabetic patients (p = 0.624). On multivariate Cox analysis, hazard ratio (HR) and 95% Confidence Intervals (95%CI) for diabetic patients associated with MACCE were miR-134-5p (1.12; 1.05–1.21, p < 0.001), miR-499-5p (0.16; 0.02–1.32, p = 0.089), hs-CRP (1.14; 1.02–1.28; p = 0.022), prior myocardial infarction (8.56, 1.91–38.3, p = 0.004), LEAD (11.9; 2.99–47.9, p = 0.005), and RAS (20.2; 2.4–167.5, p = 0.005), while in non-diabetic subjects, only miR-16-5p (1.0006; 1.0001–1.0012, p = 0.016), miR-208b-3p (2.82; 0.91–8.71, p = 0.071), and hypertension (0.27, 0.08–0.95, p = 0.042) were associated with MACCE. Our study demonstrated that different circulating miRs may be prognostic for MACCE in diabetic versus non-diabetic patients with symptomatic ICAS. Higher expression levels of miR-134 were prognostic for MACCE in diabetic patients, while higher expression levels of miR-16 were prognostic in non-diabetic patients.
Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study
Authors: Ilgisonis Ekaterina V. , Shalina Raisa , Kasum-Zade Nigyar , Burkova Kristina G. , Trifonova Oxana P. , Maslov Dmitry L. , Kaysheva Anna L. , Markin Sergey S.
Published: April 2022

We sought to identify the characteristic metabolite profile of blood plasma samples obtained from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. We performed a comparative analysis of the metabolite profiles and found that they differed between pregnant women with and without preeclampsia. Lipids and sugars were identified as components of the metabolite profile that are likely to be associated with the development of preeclampsia. While PE was established only in the third trimester, a set of metabolites specific for the third trimester, including 2-(acetylamino)-1,5-anhydro-2-deoxy-4-O-b-D-galactopyranosyl-D-arabino-Hex-1-enitol, N-Acetyl-D-glucosaminyldiphosphodolichol, Cer(d18:0/20:0), and allolithocholic acid, was already traced in the first trimester. These components are also likely involved in lipid metabolism disorders and the development of oxidative stress.
Electroporation and Electrochemotherapy in Gynecological and Breast Cancer Treatment
Authors: Łapińska Zofia , Szwedowicz Urszula , Choromańska Anna , Saczko Jolanta
Published: April 2022

Gynecological carcinomas affect an increasing number of women and are associated with poor prognosis. The gold standard treatment plan is mainly based on surgical resection and subsequent chemotherapy with cisplatin, 5-fluorouracil, anthracyclines, or taxanes. Unfortunately, this treatment is becoming less effective and is associated with many side effects that negatively affect patients’ physical and mental well-being. Electroporation based on tumor exposure to electric pulses enables reduction in cytotoxic drugs dose while increasing their effectiveness. EP-based treatment methods have received more and more interest in recent years and are the subject of a large number of scientific studies. Some of them show promising therapeutic potential without using any cytotoxic drugs or molecules already present in the human body (e.g., calcium electroporation). This literature review aims to present the fundamental mechanisms responsible for the course of EP-based therapies and the current state of knowledge in the field of their application in the treatment of gynecological neoplasms.
Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
Authors: Pasierski Michał , Szulczyk Bartłomiej
Published: April 2022

Capsaicin is a natural compound found in chili peppers and is used in the diet of many countries. The important mechanism of action of capsaicin is its influence on TRPV1 channels in nociceptive sensory neurons. Furthermore, the beneficial effects of capsaicin in cardiovascular and oncological disorders have been described. Many recent publications show the positive effects of capsaicin in animal models of brain disorders. In Alzheimer’s disease, capsaicin reduces neurodegeneration and memory impairment. The beneficial effects of capsaicin in Parkinson’s disease and depression have also been described. It has been found that capsaicin reduces the area of infarction and improves neurological outcomes in animal models of stroke. However, both proepileptic and antiepileptic effects of capsaicin in animal models of epilepsy have been proposed. These contradictory results may be caused by the fact that capsaicin influences not only TRPV1 channels but also different molecular targets such as voltage-gated sodium channels. Human studies show that capsaicin may be helpful in treating stroke complications such as dysphagia. Additionally, this compound exerts pain-relieving effects in migraine and cluster headaches. The purpose of this review is to discuss the mechanisms of the beneficial effects of capsaicin in disorders of the central nervous system.
Recent Advances in Synergistic Antitumor Effects Exploited from the Inhibition of Ataxia Telangiectasia and RAD3-Related Protein Kinase (ATR)
Authors: Wang Li-Wei , Jiang Songwei , Yuan Ying-Hui , Duan Jilong , Mao Nian-Dong , Hui Zi , Bai Renren , Xie Tian , Ye Xiang-Yang
Published: April 2022

As one of the key phosphatidylinositol 3-kinase-related kinases (PIKKs) family members, ataxia telangiectasia and RAD3-related protein kinase (ATR) is crucial in maintaining mammalian cell genomic integrity in DNA damage response (DDR) and repair pathways. Dysregulation of ATR has been found across different cancer types. In recent years, the inhibition of ATR has been proven to be effective in cancer therapy in preclinical and clinical studies. Importantly, tumor-specific alterations such as ATM loss and Cyclin E1 (CCNE1) amplification are more sensitive to ATR inhibition and are being exploited in synthetic lethality (SL) strategy. Besides SL, synergistic anticancer effects involving ATRi have been reported in an increasing number in recent years. This review focuses on the recent advances in different forms of synergistic antitumor effects, summarizes the pharmacological benefits and ongoing clinical trials behind the biological mechanism, and provides perspectives for future challenges and opportunities. The hope is to draw awareness to the community that targeting ATR should have great potential in developing effective anticancer medicines.
The Dysregulation of the Renin–Angiotensin System in COVID-19 Studied by Serum Proteomics: Angiotensinogen Increases with Disease Severity
Authors: Tepasse Phil-Robin , Vollenberg Richard , Steinebrey Nico , König Simone
Published: April 2022

(1) Background: ACE and CPN serum activity correlated with disease severity in an earlier study of 45 hospitalized COVID-19 patients. The serum protein profile was investigated in the same cohort here to shed more light on the involvement of the renin–angiotensin system (RAS). (2) Methods: High-definition mass spectrometry-based protein expression analysis was performed, followed by multivariate statistical and network analyses. (3) Results: The protein profiles of hospitalized patients (HoP) differed significantly from those of convalescent and healthy probands. Surprisingly, HoP samples separated into six groups according to their protein profiles: group (G) 1 represented the youngest and the least afflicted patients, and G6 the oldest and critically ill patients. At least two major pathophysiological schemes were indicated based on differing involvement of the kallikrein-kinin system (KKS), the RAS and complement activation. The serum angiotensinogen concentration increased with disease severity. (4) Conclusions: The important role of the RAS in the response to COVID-19 infection was substantiated, but other pathways such as the KKS, plasminogen activation and complement activation influence the systemic response to the infection.
Nanoencapsulation Strategies for Active Compounds Delivery
Authors: Carbone Claudia , Caddeo Carla , Musumeci Teresa
Published: April 2022

Nanoencapsulation strategies, including the possibility to deliver natural compounds, synthetic molecules, or other actives (viruses) for the treatment of different human diseases, represent a hot topic of great interest [...]
Surface-Plasmon-Assisted Growth, Reshaping and Transformation of Nanomaterials
Authors: Zhang Chengyun , Qi Jianxia , Li Yangyang , Han Qingyan , Gao Wei , Wang Yongkai , Dong Jun
Published: April 2022

Excitation of surface plasmon resonance of metal nanostructures is a promising way to break the limit of optical diffraction and to achieve a great enhancement of the local electromagnetic field by the confinement of optical field at the nanoscale. Meanwhile, the relaxation of collective oscillation of electrons will promote the generation of hot carrier and localized thermal effects. The enhanced electromagnetic field, hot carriers and localized thermal effects play an important role in spectral enhancement, biomedicine and catalysis of chemical reactions. In this review, we focus on surface-plasmon-assisted nanomaterial reshaping, growth and transformation. Firstly, the mechanisms of surface-plasmon-modulated chemical reactions are discussed. This is followed by a discussion of recent advances on plasmon-assisted self-reshaping, growth and etching of plasmonic nanostructures. Then, we discuss plasmon-assisted growth/deposition of non-plasmonic nanostructures and transformation of luminescent nanocrystal. Finally, we present our views on the current status and perspectives on the future of the field. We believe that this review will promote the development of surface plasmon in the regulation of nanomaterials.
The Foetal Origins of Allergy and Potential Nutritional Interventions to Prevent Disease
Authors: Warner John O. , Warner Jill Amanda
Published: April 2022

The first nine months from conception to birth involves greater changes than at any other time in life, affecting organogenesis, endocrine, metabolic and immune programming. It has led to the concept that the “first 1000 days” from conception to the second birthday are critical in establishing long term health or susceptibility to disease. Immune ontogeny is predominantly complete within that time and is influenced by the maternal genome, health, diet and environment pre-conception and during pregnancy and lactation. Components of the immunological protection of the pregnancy is the generation of Th-2 and T-regulatory cytokines with the consequence that neonatal adaptive responses are also biased towards Th-2 (allergy promoting) and T-regulatory (tolerance promoting) responses. Normally after birth Th-1 activity increases while Th-2 down-regulates and the evolving normal human microbiome likely plays a key role. This in turn will have been affected by maternal health, diet, exposure to antibiotics, mode of delivery, and breast or cow milk formula feeding. Complex gene/environment interactions affect outcomes. Many individual nutrients affect immune mechanisms and variations in levels have been associated with susceptibility to allergic disease. However, intervention trials employing single nutrient supplementation to prevent allergic disease have not achieved the expected outcomes suggested by observational studies. Investigation of overall dietary practices including fresh fruit and vegetables, fish, olive oil, lower meat intake and home cooked foods as seen in the Mediterranean and other healthy diets have been associated with reduced prevalence of allergic disease. This suggests that the “soup” of overall nutrition is more important than individual nutrients and requires further investigation both during pregnancy and after the infant has been weaned. Amongst all the potential factors affecting allergy outcomes, modification of maternal and infant nutrition and the microbiome are easier to employ than changing other aspects of the environment but require large controlled trials before recommending changes to current practice.
Periphery-Brain Interactions and Leptin in the Regulation of Whole-Body Energy Metabolism
Authors: Hankir Mohammed Khair , Bruneau Michael
Published: April 2022

In order to combat overweight and obesity as a global public health issue and prevent its impact on other debilitating cardiovascular, metabolic and renal diseases, a better understanding of the processes regulating energy metabolism are essential [...]
Time to Consider the “Exposome Hypothesis” in the Development of the Obesity Pandemic
Authors: Catalán Victoria , Avilés-Olmos Iciar , Rodríguez Amaia , Becerril Sara , Fernández-Formoso José Antonio , Kiortsis Dimitrios , Portincasa Piero , Gómez-Ambrosi Javier , Frühbeck Gema
Published: April 2022

The obesity epidemic shows no signs of abatement. Genetics and overnutrition together with a dramatic decline in physical activity are the alleged main causes for this pandemic. While they undoubtedly represent the main contributors to the obesity problem, they are not able to fully explain all cases and current trends. In this context, a body of knowledge related to exposure to as yet underappreciated obesogenic factors, which can be referred to as the “exposome”, merits detailed analysis. Contrarily to the genome, the “exposome” is subject to a great dynamism and variability, which unfolds throughout the individual’s lifetime. The development of precise ways of capturing the full exposure spectrum of a person is extraordinarily demanding. Data derived from epidemiological studies linking excess weight with elevated ambient temperatures, in utero, and intergenerational effects as well as epigenetics, microorganisms, microbiota, sleep curtailment, and endocrine disruptors, among others, suggests the possibility that they may work alone or synergistically as several alternative putative contributors to this global epidemic. This narrative review reports the available evidence on as yet underappreciated drivers of the obesity epidemic. Broadly based interventions are needed to better identify these drivers at the same time as stimulating reflection on the potential relevance of the “exposome” in the development and perpetuation of the obesity epidemic.
Assessing the Nutrient Status of Low Carbohydrate, High-Fat (LCHF) Meal Plans in Children: A Hypothetical Case Study Design
Authors: Zinn Caryn , Lenferna De La Motte Kayla-Anne , Rush Amy , Johnson Rebecca
Published: April 2022

There is well-established evidence for low-carbohydrate, high-fat (LCHF) diets in the management of chronic health conditions in adults. The natural next step is to understand the potential risks and benefits of LCHF diets for children, where they may have useful applications for general health and a variety of chronic health conditions. It is vital that any diet delivers sufficient micronutrients and energy to ensure health, wellbeing, and growth. This descriptive study assesses the nutrient and energy status of LCHF sample meal plans for children. We designed four meal plans for hypothetical weight-stable male and female children (11 years) and adolescents (16 years). Carbohydrates were limited to ≤80 g, protein was set at 15–25% of the total energy, and fat supplied the remaining calories. Using FoodWorks dietary analysis software, data were assessed against the national Australian/New Zealand nutrient reference value (NRV) thresholds for children and adolescents. All meal plans exceeded the minimum NRV thresholds for all micronutrients; protein slightly exceeded the AMDR recommendations by up to three percentage points. This study demonstrates that LCHF meal plans can be energy-, protein-, and micronutrient-replete for children and adolescents. As with any dietary approach, well-formulated meals and careful planning are key to achieving the optimal nutrient status.
Can Low-Dose of Dietary Vitamin E Supplementation Reduce Exercise-Induced Muscle Damage and Oxidative Stress? A Meta-Analysis of Randomized Controlled Trials
Authors: Kim Myunghee , Eo Hyeyoon , Lim Josephine Gahyun , Lim Hyunjung , Lim Yunsook
Published: April 2022

Vitamin E plays an important role in attenuating muscle damage caused by oxidative stress and inflammation. Despites of beneficial effects from antioxidant supplementation, effects of antioxidants on exercise-induced muscle damage are still unclear. The aim of this meta-analysis was to investigate the effects of dietary vitamin E supplementation on exercise-induced muscle damage, oxidative stress, and inflammation in randomized controlled trials (RCTs). The literature search was conducted through PubMed, Medline, Science Direct, Scopus, SPORTDiscuss, EBSCO, Google Scholar database up to February 2022. A total of 44 RCTs were selected, quality was assessed according to the Cochrane collaboration risk of bias tool (CCRBT), and they were analyzed by Revman 5.3. Dietary vitamin E supplementation had a protective effect on muscle damage represented by creatine kinase (CK; SMD −1.00, 95% CI: −1.95, −0.06) and lactate dehydrogenase (SMD −1.80, 95% CI: −3.21, −0.39). Muscle damage was more reduced when CK was measured immediately after exercise (SMD −1.89, 95% CI: −3.39, −0.39) and subjects were athletes (SMD −5.15, 95% CI: −9.92, −0.39). Especially vitamin E supplementation lower than 500 IU had more beneficial effects on exercise-induced muscle damage as measured by CK (SMD −1.94, 95% CI: −2.99, −0.89). In conclusion, dietary vitamin E supplementation lower than 500 IU could prevent exercise-induced muscle damage and had greater impact on athletes
Perioperative Nutritional Support: A Review of Current Literature
Authors: Martínez-Ortega Antonio Jesús , Piñar-Gutiérrez Ana , Serrano-Aguayo Pilar , González-Navarro Irene , Remón-Ruíz Pablo Jesús , Pereira-Cunill José Luís , García-Luna Pedro Pablo
Published: April 2022

Since the beginning of the practice of surgery, the reduction of postoperative complications and early recovery have been two of the fundamental pillars that have driven the improvement of surgical techniques and perioperative management. Despite great advances in these fields, the rationalization of antibiotic prophylaxis, and other important innovations, postoperative recovery (especially in elderly patients, oncological pathology or digestive or head and neck surgery) is tortuous. This can be explained by several reasons, among which, malnutrition has a major role. Perioperative nutritional support, included within the ERAS (Enhanced Recovery After Surgery) protocol, has proven to be a main element and a critical step to achieve better surgical results. Starting with the preoperative nutritional assessment and treatment in elective surgery, we can improve nutritional status using oral supplements and immunomodulatory formulas. If we add early nutritional support in the postoperative scenario, we are able to significantly reduce infectious complications, need for intensive care unit (ICU) and hospital stay, costs, and mortality. Throughout this review, we will review the latest developments and the available literature.
Molecular Mechanisms Underlying the Effects of Olive Oil Triterpenic Acids in Obesity and Related Diseases
Authors: Claro-Cala Carmen M. , Jiménez-Altayó Francesc , Zagmutt Sebastián , Rodriguez-Rodriguez Rosalia
Published: April 2022

Dietary components exert protective effects against obesity and related metabolic and cardiovascular disturbances by interfering with the molecular pathways leading to these pathologies. Dietary biomolecules are currently promising strategies to help in the management of obesity and metabolic syndrome, which are still unmet medical issues. Olive oil, a key component of the Mediterranean diet, provides an exceptional lipid matrix highly rich in bioactive molecules. Among them, the pentacyclic triterpenic acids (i.e., oleanolic acid) have gained clinical relevance in the last decade due to their wide range of biological actions, particularly in terms of vascular function, obesity and insulin resistance. Considering the promising effects of these triterpenic compounds as nutraceuticals and components of functional foods against obesity and associated complications, the aim of our review is to decipher and discuss the main molecular mechanisms underlying these effects driven by olive oil triterpenes, in particular by oleanolic acid. Special attention is paid to their signaling and targets related to glucose and insulin homeostasis, lipid metabolism, adiposity and cardiovascular dysfunction in obesity. Our study is aimed at providing a better understanding of the impact of dietary components of olive oil in the long-term management of obesity and metabolic syndrome in humans.
Actions of Retinoic Acid in the Pathophysiology of HIV Infection
Authors: Sidell Neil , Kane Maureen A.
Published: April 2022

The vitamin A metabolite all-trans retinoic acid (RA) plays a key role in tissue homeostasis and mucosal immunity. RA is produced by gut-associated dendritic cells, which are among the first cells encountered by HIV. Acute HIV infection results in rapid reduction of RA levels and dysregulation of immune cell populations whose identities and function are largely controlled by RA. Here, we discuss the potential link between the roles played by RA in shaping intestinal immune responses and the manifestations and pathogenesis of HIV-associated enteropathy and similar conditions observed in SIV-infected non-human primate models. We also present data demonstrating the ability of RA to enhance the activation of replication-competent viral reservoirs from subjects on suppressive anti-retroviral therapy. The data suggest that retinoid supplementation may be a useful adjuvant for countering the pathologic condition of the gastro-intestinal tract associated with HIV infection and as part of a strategy for reactivating viral reservoirs as a means of depleting latent viral infection.
Effects of a Short-Term Lipopolysaccharides Challenge on Mouse Brain and Liver Peroxisomal Antioxidant and β-oxidative Functions: Protective Action of Argan Oil
Authors: Essadek Soukaina , Bouchab Habiba , El Kebbaj Riad , Gondcaille Catherine , El Kamouni Soufiane , Savary Stéphane , Vamecq Joseph , Essamadi Abdelkhalid , Cherkaoui-Malki Mustapha , Nasser Boubker , Andreoletti Pierre
Published: April 2022

During sepsis, the imbalance between oxidative insult and body antioxidant response causes the dysfunction of organs, including the brain and liver. Exposing mice to bacterial lipopolysaccharides (LPS) results in a similar pathophysiological outcome. The protection offered by argan oil was studied against LPS-induced oxidative stress, dysregulation of peroxisomal antioxidants, and β-oxidation activities in the brain and liver. In a short-term LPS treatment, lipid peroxidation (malonaldehyde assay) increased in the brain and liver with upregulations of proinflammatory tumor necrosis factor (Tnf)-α and anti-inflammatory interleukin (Il)-10 genes, especially in the liver. Although exposure to olive oil (OO), colza oil (CO), and argan oil (AO) prevented LPS-induced lipid peroxidation in the brain and liver, only AO exposure protected against liver inflammation. Remarkably, only exposure to AO prevented LPS-dependent glutathione (GSH) dysregulation in the brain and liver. Furthermore, exposure to AO increased more efficiently than OO and CO in both organs, peroxisomal antioxidant capacity via induction of catalase (Cat) gene, protein and activity expression levels, and superoxide dismutase (Sod1) mRNA and activity levels. Interestingly, LPS decreased protein levels of the peroxisomal fatty acid-ATP binding cassette (ABC) transporters, ABCD1 and ABCD2, and increased acyl-CoA oxidase 1 (ACOX1) protein expression. Moreover, these LPS effects were attenuated for ABCD1 and ACOX1 in the brain of mice pretreated with AO. Our data collectively highlight the protective effects of AO against early oxidative stress caused by LPS in the brain and liver and their reliance on the preservation of peroxisomal functions, including antioxidant and β-oxidation activities, making AO a promising candidate for the prevention and management of sepsis.
Evening Primrose Oil Improves Chemotherapeutic Effects in Human Pancreatic Ductal Adenocarcinoma Cell Lines—A Preclinical Study
Authors: Zeppa Laura , Aguzzi Cristina , Versari Giorgia , Luongo Margherita , Morelli Maria Beatrice , Maggi Federica , Amantini Consuelo , Santoni Giorgio , Marinelli Oliviero , Nabissi Massimo
Published: April 2022

Evening Primrose oil (EPO), obtained from the seeds of Evening Primrose (Oenothera L.), is largely used as a dietary supplement, especially after cancer diagnosis. Human pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease correlated with poor clinical prognosis and a very low response rate to common chemotherapy. The aim of this work was to study the potential ability of EPO to improve the effects of chemotherapeutic drugs in PANC-1 and MIAPaCa-2 cell lines. Cytotoxicity, cell death, reactive oxygen species (ROS) production and EPO anticancer activity associated with the main chemotherapeutic drugs commonly used in therapy were investigated. Results showed that EPO reduced PDAC cell viability and increased paclitaxel efficacy. This evidence suggests that EPO may be used as a potential supplement to increase chemotherapeutic efficacy in PDAC therapy.
Cu-Doped Hollow Bioactive Glass Nanoparticles for Bone Infection Treatment
Authors: Jiménez-Holguín Javier , Sánchez-Salcedo Sandra , Cicuéndez Mónica , Vallet-Regí María , Salinas Antonio J.
Published: April 2022

In search of new approaches to treat bone infection and prevent drug resistance development, a nanosystem based on hollow bioactive glass nanoparticles (HBGN) of composition 79.5SiO2-(18-x)CaO-2.5P2O5-xCuO (x = 0, 2.5 or 5 mol-% CuO) was developed. The objective of the study was to evaluate the capacity of the HBGN to be used as a nanocarrier of the broad-spectrum antibiotic danofloxacin and source of bactericidal Cu2+ ions. Core-shell nanoparticles with specific surface areas close to 800 m2/g and pore volumes around 1 cm3/g were obtained by using hexadecyltrimethylammonium bromide (CTAB) and poly(styrene)-block-poly(acrylic acid) (PS-b-PAA) as structure-directing agents. Flow cytometry studies showed the cytocompatibility of the nanoparticles in MC3T3-E1 pre-osteoblastic cell cultures. Ion release studies confirmed the release of non-cytotoxic concentrations of Cu2+ ions within the therapeutic range. Moreover, it was shown that the inclusion of copper in the system resulted in a more gradual release of danofloxacin that was extended over one week. The bactericidal activity of the nanosystem was evaluated with E. coli and S. aureus strains. Nanoparticles with copper were not able to reduce bacterial viability by themselves and Cu-free HBGN failed to reduce bacterial growth, despite releasing higher antibiotic concentrations. However, HBGN enriched with copper and danofloxacin drastically reduced bacterial growth in sessile, planktonic and biofilm states, which was attributed to a synergistic effect between the action of Cu2+ ions and danofloxacin. Therefore, the nanosystem here investigated is a promising candidate as an alternative for the local treatment of bone infections.
The Effect of Dry Hopping Efficiency on β-Myrcene Dissolution into Beer
Authors: Salamon Rozália Veronika , Dabija Adriana , Ferencz Ágota , Tankó György , Ciocan Marius Eduard , Codină Georgiana Gabriela
Published: April 2022

The production of heavily hopped beers, such as Indian Pale Ale (IPA) styles, has been gaining momentum in recent years in the Central European markets. To this end, the dry hopping process is becoming increasingly popular, mostly in microbreweries, but also with larger manufacturers. In our research, we investigated the dissolution rate of the main volatile component of hops, β-myrcene with a modified dry hopping method. Following the primary fermentation, we applied the dry hopping process, where the weighed hops were chopped and blended into a container with 0.5 L of beer and later added to the young beer. During the dry hopping process, we determined various important parameters of the beer, and we repeated the same measurements for the bottled beer. In the first 96 h of the dry hopping process, we monitored the concentration of β-myrcene so that we managed to determine the dissolution rate constant (k = 0.1946 h−1). The β-myrcene concentration stabilizes after 44 h in the fermenter. At the same time, measurements were conducted for bitterness, pH, CO2 and alcohol content, extract and density during the process. Our experiment demonstrates that a new method of dry hopping provides a much higher concentration of β-myrcene (215 μg/L) than other methods indicated in former studies in the field. A health and safety assessment of β-myrcene was also made and we determined what the safe amount of β-myrcene ingested with IPA beer is. Our modified process was successful, we were able to determine the dissolution rate of β-myrcene, and the recommended daily intake of IPA beer with particular reference to β-myrcene.
Preparation of Magnesium Hydroxide Flame Retardant from Hydromagnesite and Enhance the Flame Retardant Performance of EVA
Authors: Jiao Ling-Li , Zhao Peng-Cheng , Liu Zhi-Qi , Wu Qing-Shan , Yan Dong-Qiang , Li Yi-Lan , Chen Yu-Nan , Li Ji-Sheng
Published: April 2022

In this study, hydromagnesite, a rare natural hydrated alkaline magnesium carbonate, was used to synthesize magnesium hydroxide (MH) as a flame retardant for ethylene-vinyl acetate (EVA) to enhance its fire resistance and smoke suppression. Various concentrations of sodium hydroxide (NaOH) were used to alter the morphology and the flame-retardant efficiency of synthesized MH. EVA/MH composites were prepared through melt blending, and the influence of NaOH on the flame retardancy and mechanical properties was investigated by means of the limiting oxygen index (LOI), cone calorimeter test (CCT) and tensile test. The flame retardancy results demonstrated that composites exhibited remarkably improved flame retardant properties after introducing MH, reflected by an increase in the LOI value from 20% for neat EVA to roughly 38%. Additionally, the peak of heat release rate (pHRR), the total heat release (THR) and the peak of the smoke production rate for EVA3 were decreased by 37.6%, 20.7% and 44.4% compared with neat EVA, respectively. In the meantime, increasing char residues were also observed. The incorporation of different MH concentrations had a limited effect on the mechanical properties of the EVA/MH composites.
Effect of Crystallization on Shape Memory Effect of Poly(lactic Acid)
Authors: Nie Danli , Yin Xianze , Cai Ziqing , Wang Jintao
Published: April 2022

The opportunity for the preparation of high-performance shape memory materials was brought about by the excellent mechanical properties of poly(lactic acid) (PLA). As the effect of crystallization on shape memory was still unclear, this brings constraints to the high-performance design of PLA. The PLA plates with different aggregation structure were prepared by three kinds of molding methods in this paper. The PLA plates were pre-stretched with a series of different strains above glass transition temperature (i.e., 70 °C). The recovery stress and ratio of the material were measured above stretching temperature (i.e., 80 °C). Prolonging of annealing time resulted in more perfect crystal structure and higher crystallinity. The crystal region acted as network nodes in shape memory PLA, and crystal region structure determined the shape memory performance. Based on the experimental results, the structural evolution of network nodes in shape memory PLA was established.
Enhancing Thermal Insulation of EPDM Ablators via Constructing Alternating Planar Architectures
Authors: Qu Hongjian , Wang Le , Hui Kun , Bian Cheng , Li Hongyan , Guan Yiwen , Luan Tao , Yan Ning
Published: April 2022

Ethylene–propylene–diene monomer (EPDM) composites were usually enhanced with ablative additives to protect solid rocket motor (SRMs) casings. However, the poor thermal insulation caused by the high thermal conductive ablative fillers can lead to rocket motor failure. Herein, the novel EPDM composites containing alternating layers of ablative EPDM (AM) and heat-insulated EPDM (HM) were prepared through layer-multiplying extrusion. Compared with conventional EPDM ablative material, the multilayer composites showed enhanced thermal insulation and mechanical properties that could be further improved by tuning the number of layers. The ablation and thermal insulation properties possessing in AM and HM layers could be combined by forced assembly during co-extrusion, and the alternating multilayer composite was capable of showing the effect of each component. In particular, compared with AM, the maximum back-face temperature with 40 alternating layers of AM/HM decreased from 96.2 °C to 75.6 °C during oxyacetylene test, while the good ablation properties were preserved in the AM component. This significant improvement was attributed to the planar orientation and densification of ablative additives, and the interruption of conductive pathways in the through-plane direction of AM/HM alternating laminate. The anisotropic EPDM composites featuring mechanical robustness, good ablative resistance and thermal insulation suggest considerable potential application in the aerospace industry.
Red Seaweed (Gracilaria verrucosa Greville) Based Polyurethane as Adsorptive Membrane for Ammonia Removal in Water
Authors: Nurman Salfauqi , Saiful  , Rahmi  , Ginting Binawati , Marlina
Published: April 2022

Polyurethane membranes are widely developed polymers by researchers because they can be made from synthetic materials or natural materials. Red seaweed (Gracilaria verrucosa Greville) is a natural material that can be developed as a raw material for polyurethane membranes. This study used red seaweed biomass (RSB) as a raw material to manufacture polyurethane as an adsorptive membrane for removing ammonia in water. The membrane composition was determined using the Box–Behnken design from Response Surface Methodology with three factors and three levels. In the ammonia adsorption process, the adsorption isotherm was determined by varying the concentration, while the adsorption kinetics was determined by varying the contact time. Red seaweed biomass-based polyurethane membrane (PUM-RSB) can adsorb ammonia in water with an adsorption capacity of 0.233 mg/g and an adsorption efficiency of 16.2%. The adsorption efficiency followed the quadratic model in the Box–Behnken design, which resulted in the optimal composition of RSB 0.15 g, TDI 3.0 g, and glycerin 0.4 g with predicted and actual adsorption capacities of 0.224 mg/g and 0.226 mg/g. The ammonia adsorption isotherm using PUM-RSB follows the Freundlich isotherm, with a high correlation coefficient (R2) of 0.977, while the Langmuir isotherm has a low R2 value of 0.926. The Freundlich isotherm indicates that ammonia is adsorbed on the surface of the adsorbent as multilayer adsorption. In addition, based on the analysis of adsorption kinetics, the adsorption phenomenon follows pseudo-order II with a chemisorption mechanism, and it is assumed that the bond that occurs is between the anion –SO42− with the NH4+ cation to form ammonium sulfate (NH4)2SO4 and between isocyanates (NCO) with NH4+ cations to form substituted urea.
Topology Optimization Combined with a Parametric Algorithm for Industrial Synchronous Reluctance Motor Design
Authors: Lee Tae-Hee , Lim Dong-Kuk , Moon Ki-Young , Jeon Kyung-Won
Published: April 2022

In this paper, we propose combining topology optimization with a parametric algorithm (TOCPA) to design an industrial synchronous reluctance motor (SynRM) that satisfies super-premium efficiency (IE4). TOCPA consists of two main processes. An improved niching algorithm is proposed as an existing parametric algorithm, and multiple optimal points were identified quickly and effectively within the design range specified by the user. Existing parametric algorithms lack the ability to find unpredictable new optimal shapes; therefore, topology optimization has been added. TOCPA converges the two optimization methods to compensate for the shortcomings of each and maximizes the advantages. In addition, the boundary surface ON–OFF method is applied to accelerate the topology optimization process. Subsequent ratio-based smoothing techniques smooth out discontinuous interfaces and remove clusters to improve the torque characteristics and reduce the manufacturing difficulty. Finally, the torque ripple was reduced using the skew technique, and mechanical stability was confirmed using a stress analysis. An IE4 industrial SynRM was successfully designed using TOCPA.
Narrating and Remembrance in the Face of Abuse in the Church
Authors: Heyder Regina
Published: April 2022

Contrary to the priority of protecting the institutional Church and its clergy, prevailing for decades and centuries, today the testimonies of victims of sexual abuse are increasingly being heard. This article focuses on autobiographical accounts of women, published in recent years, who as adults suffered from sexual and spiritual violence within the Catholic Church. It analyses characteristics of spiritual and sexual abuse, identifies specific constellations and a misogynistic theology. Complementary to this, traumatic experiences of flight and expulsion, as described by the theologian Katharina Elliger, are examined. Thus, this article describes the meaning of narrating one’s traumatic experiences for the authors themselves and suggests collective remembrance as an appropriate reaction of the Church and the society.
Buddhist Modernism and the Piety of Female Sex Workers in Northern Thailand
Authors: Kidpromma Amnuaypond
Published: April 2022

This paper highlights Thailand’s distinctive form of Buddhist Modernism through an exploration of religious piety among female sex workers in the city of Chiangmai. The generally accepted key basis of Buddhist Modernism, as depicted by certain Western Buddhist scholars, is interaction and engagement with modernity. More specifically, it is seen as incorporating modern science into the Buddhist worldview, and as regarding meditation as a core practice of ‘true Buddhism’. Crucial components of popular Buddhism, such as magical monks and mystical rituals, are excluded from this depiction of Buddhist Modernism, and even decried as ‘false Buddhism’, despite their canonical basis and long-term acceptance. Using ethnographic methods, this paper argues instead that the result of interactions with modernity by popular Buddhists always includes engagement with and mythologizing of traditional cosmology. That is, rather than solely involving global networks and scientific rationalism, Thai Buddhist Modernism is the product of complex patterns of interaction among local beliefs, mystical practices, and modernity. The purpose of this integration of modern and popular Buddhism in the religious practices of sex workers is to create loving-kindness (metta). Metta, in turn, is held to bring luck and attractiveness to practitioners, allowing them to earn an income to support their impoverished families and live well in modern society, as well as to accumulate good merit (bun) to improve their religious lives.
Catholic Seminarians on “Real Men”, Sexuality, and Essential Male Inclusivity
Authors: Barnes Medora W.
Published: April 2022

This paper is based on an empirical study using in-depth qualitative interviews that examines how Roman Catholic undergraduate seminarians in the United States understand gender, sexuality and masculinity. The findings describe how seminarians reject interactionist and social constructionist models of gender, and rely on a strict biological based model where sex/gender are seen as a unified concept. This leads them to adopt an “essential male inclusivity”, where they argue that all people assigned male at birth have equal claim to “manhood”, which eases pressures on them to act in gender normative ways. The social-psychological and identity-based motivations of these beliefs are examined in connection to their life in the seminary and other anticipated occupational characteristics. In contrast, the seminary’s mandates around both celibacy and compulsory heterosexuality, make sexuality more fraught than gender for seminarians. The larger consequences of these perspectives are also explored in regard to gender inequality, homophobia, and the lack of acceptance for the LGBTIQ+ community.
Elasto-Geometrical Model-Based Control of Industrial Manipulators Using Force Feedback: Application to Incremental Sheet Forming
Authors: Johra Marwan , Courteille Eric , Deblaise Dominique , Guégan Sylvain
Published: April 2022

This paper aims to improve the positioning accuracy of serial industrial manipulators using force feedback in manufacturing processes by implementing an elasto-geometrical model-based control. Initially, the real-time position control strategy using a force feedback to elastically correct the Tool Center Point (TCP) pose of serial industrial manipulators is detailed. To continue, an efficient model structure identification and calibration is proposed to shorten the elasto-geometrical modeling process. The Virtual Joint Method (VJM) is chosen to iterate and complete the robot stiffness modeling. This method considers that the elastic deformations are only localized at the joints of the robot. An appropriate and original test-model approach allows a minimum of optimization iterations to find the best compromise between complexity and accuracy of the modeling. The proposed approach is illustrated in detail by the Stäubli TX200 robot modeling. Finally, the reliability and responsiveness of the developed control framework is then evaluated through experimental tests in an Incremental Sheet Forming (ISF) context. An average improvement of 70% in trajectory-tracking accuracy is achieved during these tests. Overall, the high accuracy and responsiveness of the developed system demonstrate a promising potential for deploying industrial manipulators to a cost-effective manufacturing processes in industry 4.0.
Assessments of Cloud Liquid Water and Total Precipitable Water Derived from FY-3E MWTS-III and NOAA-20 ATMS
Authors: Dong Changjiao , Weng Fuzhong , Yang Jun
Published: April 2022

Cloud liquid water (CLW) and total precipitable water (TPW) are two important parameters for weather and climate applications. Typically, microwave temperature sounding instruments onboard satellites are designed with two low-frequency channels at 23.8 and 31.4 GHz and can be used for retrieving CLW and TPW over global oceans. Since MWTS-III polarization at above two frequencies is uncertain, we must first determine their polarization involved in retrieval algorithms. Through radiative transfer simulation, we found that uses of the quasi-horizontal polarization for MWTS-III can produce smaller biases between observations and simulations and the scan-angle dependence of the biases is also in a general frown pattern, which is similar to ATMS pitch-maneuver observations. After the characterization of MWTS-III polarization, CLW and TPW are derived from Microwave Temperature Sounder (MWTS-III) and are compared with those from ATMS. It is found that CLW and TPW derived from two instruments exhibit a high consistency in terms of their spatial distributions and magnitudes.
Verification of Satellite Railway Track Position Measurements Making Use of Standard Coordinate Determination Techniques
Authors: Szmagliński Jacek , Wilk Andrzej , Koc Władysław , Karwowski Krzysztof , Chrostowski Piotr , Skibicki Jacek , Grulkowski Sławomir , Judek Sławomir , Licow Roksana , Makowska-Jarosik Karolina , Michna Michał , Widerski Tadeusz
Published: April 2022

The article presents the results of satellite railway track position measurements performed by a multidisciplinary research team, the members of which represented Gdansk University of Technology and Gdynia Maritime University. Measuring methods are described which were used for reconstructing the railway track axis position and diagnosing railway track geometry deformations. As well as that, the description of the novel method developed by the authors to perform mobile GNSS measurements is included. The reported research aimed at assessing the uncertainty of railway track axis reconstruction making use of the dynamic GNSS method. To assess the applicability of this method, the obtained results were compared with those from the stationary measurement method used in railway business. The data used for comparison was recorded on the same railway track section during several measurement campaigns. In these campaigns, different types of GNSSs with different position recording frequencies (1–100 Hz) were used at different measurement speeds (5–70 km/h). The performed analysis has shown that the accuracy of railway track axis reconstruction making use of mobile GNSS measurements is sufficient for using this methodology in railway business.