bluuebunny/crossref_metadata_2025 huggingface dataset:
MCAs in Arabidopsis are Ca2+-permeable mechanosensitive channels inherently sensitive to membrane tension
Authors: Yoshimura Kenjiro , Iida Kazuko , Iida Hidetoshi
Published: October 2021

Mechanosensitive (MS) ion channels respond to mechanical stress and convert it into intracellular electric and ionic signals. Five MS channel families have been identified in plants, including the Mid1-Complementing Activity (MCA) channel; however, its activation mechanisms have not been elucidated in detail. We herein demonstrate that the MCA2 channel is a Ca2+-permeable MS channel that is directly activated by membrane tension. The N-terminal 173 residues of MCA1 and MCA2 were synthesized in vitro, purified, and reconstituted into artificial liposomal membranes. Liposomes reconstituted with MCA1(1-173) or MCA2(1-173) mediate Ca2+ influx and the application of pressure to the membrane reconstituted with MCA2(1-173) elicits channel currents. This channel is also activated by voltage. Blockers for MS channels inhibit activation by stretch, but not by voltage. Since MCA proteins are found exclusively in plants, these results suggest that MCA represent plant-specific MS channels that open directly with membrane tension.
Non-KREEP origin for Chang’e-5 basalts in the Procellarum KREEP Terrane
Authors: Tian Heng-Ci , Wang Hao , Chen Yi , Yang Wei , Zhou Qin , Zhang Chi , Lin Hong-Lei , Huang Chao , Wu Shi-Tou , Jia Li-Hui , Xu Lei , Zhang Di , Li Xiao-Guang , Chang Rui , Yang Yue-Heng , Xie Lie-Wen , Zhang Dan-Ping , Zhang Guang-Liang , Yang Sai-Hong , Wu Fu-Yuan
Published: October 2021

Mare volcanics on the Moon are the key record of thermo-chemical evolution throughout most of lunar history1–3. Young mare basalts—mainly distributed in a region rich in potassium, rare-earth elements and phosphorus (KREEP) in Oceanus Procellarum, called the Procellarum KREEP Terrane (PKT)4—were thought to be formed from KREEP-rich sources at depth5–7. However, this hypothesis has not been tested with young basalts from the PKT. Here we present a petrological and geochemical study of the basalt clasts from the PKT returned by the Chang’e-5 mission8. These two-billion-year-old basalts are the youngest lunar samples reported so far9. Bulk rock compositions have moderate titanium and high iron contents  with KREEP-like rare-earth-element and high thorium concentrations. However, strontium–neodymium isotopes indicate that these basalts were derived from a non-KREEP mantle source. To produce the high abundances of rare-earth elements and thorium, low-degree partial melting and extensive fractional crystallization are required. Our results indicate that the KREEP association may not be a prerequisite for young mare volcanism. Absolving the need to invoke heat-producing elements in their source implies a more sustained cooling history of the lunar interior to generate the Moon’s youngest melts.
Nondetrimental impact of two concomitant entomopathogenic fungi on life history parameters of a generalist predator, Coccinella septempunctata (Coleoptera: Coccinellidae)
Authors: Rizwan Muhammad , Atta Bilal , Arshad Muhammad , Khan Rashad Rasool , Dageri Asli , Rizwan Misbah , Ullah Muhammad Irfan
Published: October 2021

The non-persistent impact of biocontrol agents can be revealed for pest control when associated entomopathogenic fungi (EPFs) negatively affect the natural enemies. In this assay, impacts ofBeauvaria bassiana(Balsamo) Vuillemin, andMetarhizium anisopliae(Metschnikoff) Sorokin were studied for their compatibility or side effects on life table parameters of an important generalist predator,Coccinella septempunctataL. The results indicated non-significant impacts of both EPFs on life table parameters ofC. septempunctata. The development time (egg-adult) was not significantly different in control (69.79 days) and EPFs treatedC. septempunctata(69.35–80.07 days). Both fungi did not induce any significant changes in the fecundity, adult pre-oviposition period (APOP), total preoviposition period (TPOP), and mean generation time (T) as compared to control treatment. Similarly, no difference in fecundity rate ofC. septempunctatawas observed after EPFs treatment (287.7–288.5) compared to control (290.0). The highest net reproductive rate (R0) occurred in control (87.05 offspring individual−1) andM. anisopliae(86.31 offspring individual−1) as compared toB. bassianatreated beetles (76.97 offspring individual−1). The age-specific fecundity curves indicated that theC. septempunctatahad a similar fecundity rate in both EPFs treatments and control. This study demonstrates no significant side effects ofB. bassianaandM. anispoliaeon the performance and biology ofC. septempunctata. Considering the compatibility of both EPFs withC. septempunctata, their combinations can be recommended in various integrated pest management programs.
Optimizing the use of acoustic materials in office buildings
Authors: AlOmani Abdullah , El-Rayes Khaled , Altuwaim Ayman
Published: October 2021

Office space designers encounter a challenge in identifying the optimal set of noise control materials to improve the acoustic quality while keeping the cost of selected acoustic materials to a minimum. To address this challenge, this paper presents a novel optimization model that provides the capability of minimizing the cost of acoustic materials while satisfying all designer-specified acoustic quality requirements. The model is developed in five main stages that focus on (1) identifying the correlated designer decisions that influence the model objective function; (2) formulating an optimization objective function; (3) identifying the model constraints that are organized into acoustic quality and materials selection constraints; (4) implementing the model using genetic algorithms (GA); and (5) evaluating the performance of the model using an office space design that is under construction to assess and improve the model feasibility and performance. The outcome of the performance evaluation stage illustrates the novel capabilities of the developed model in identifying the optimal selections for the type and area of acoustic material for each surface in the office space that achieve the desired acoustic quality while keeping the cost of selected acoustic materials to a minimum.
Gastric cancer stem cells survive in stress environments via their autophagy system
Authors: Togano Shingo , Yashiro Masakazu , Masuda Go , Sugimoto Atsushi , Miki Yuichiro , Yamamoto Yurie , Sera Tomohiro , Kushiyama Shuhei , Nishimura Sadaaki , Kuroda Kenji , Okuno Tomohisa , Ohira Masaichi
Published: October 2021

Cancer stem cells (CSCs) play an important role in the progression of carcinoma and have a high potential for survival in stress environments. However, the mechanisms of survival potential of CSCs have been unclear. The aim of this study was to clarify the significance of autophagy systems of CSCs under stress environments. Four gastric cancer cell line were used. Side population (SP) cells were sorted from the parent cells, as CSC rich cells. The expression of stem cell markers was examined by RT-PCR. The viability of cancer cells under starvation and hypoxia was evaluated. The expression level of the autophagy molecule LC3B-II was examined by western blot. The numbers of autophagosomes and autolysosomes were counted by electron microscope. SP cells of OCUM-12 showed a higher expression of stem cell markers and higher viability in starvation and hypoxia. Western blot and electron microscope examinations indicated that the autophagy was more induced in SP cells than in parent cells. The autophagy inhibitor significantly decreased the viability under the stress environments. These findings suggested that Cancer stem cells of gastric cancer might maintain their viability via the autophagy system. Autophagy inhibitors might be a promising therapeutic agent for gastric cancer.
Upregulation of CD22 by Chidamide promotes CAR T cells functionality
Authors: Yang Xin , Yu Qiuxia , Xu Hao , Zhou Jianfeng
Published: October 2021

Treatment failure or relapse due to tumor escape caused by reduction in target antigen expression has become a challenge in the field of CART therapy. Target antigen density is closely related to the effectiveness of CART therapy, and reduced or lost target antigen expression limits the efficacy of CART therapy and hinders the durability of CAR T cells. Epigenetic drugs can regulate histones for molecular modifications to regulate the transcriptional, translational and post-translational modification processes of target agents, and we demonstrated for the first time the role in regulating CD22 expression and its effect on the efficacy of CD22 CART. In this paper, we found that Chidamide promoted the expression of CD22 on the surface of B-cell tumor cells in vitro and in vivo, and enhanced the function of CD22 CART. As for mechanisms, we demonstrated that Chidamide did not affect CD22 mRNA transcription, but significantly increased the expression of total CD22 protein, indicating that Chidamide may upregulate cell surface CD22 expression by affecting the distribution of CD22 protein. In summary, our results suggest that Chidamide may enhance the efficacy of CD22 CART by inhibiting histone deacetylases to regulate post-transcriptional modifications that affect protein distribution to increase the expression of CD22 on the cell surface.
Heritability and genetic correlations of plasma metabolites of pigs with production, resilience and carcass traits under natural polymicrobial disease challenge
Authors: Dervishi E. , Yang T. , Dyck M. K. , Harding J. C. S. , Fortin F. ,   PigGen Canada,    Fast Genetics ,   Genesus Genetics ,   Hypor Canada,    Topigs Canada,    DNA Genetics,    ALPHAGENE ,   Alliance Genetics, Cheng J. , Dekkers J. C. M. , Plastow G.
Published: October 2021

Metabolites in plasma of healthy nursery pigs were quantified using nuclear magnetic resonance. Heritabilities of metabolite concentration were estimated along with their phenotypic and genetic correlations with performance, resilience, and carcass traits in growing pigs exposed to a natural polymicrobial disease challenge. Variance components were estimated by GBLUP. Heritability estimates were low to moderate (0.11 ± 0.08 to 0.19 ± 0.08) for 14 metabolites, moderate to high (0.22 ± 0.09 to 0.39 ± 0.08) for 17 metabolites, and highest for l-glutamic acid (0.41 ± 0.09) and hypoxanthine (0.42 ± 0.08). Phenotypic correlation estimates of plasma metabolites with performance and carcass traits were generally very low. Significant genetic correlation estimates with performance and carcass traits were found for several measures of growth and feed intake. Interestingly the plasma concentration of oxoglutarate was genetically negatively correlated with treatments received across the challenge nursery and finisher (− 0.49 ± 0.28; P < 0.05) and creatinine was positively correlated with mortality in the challenge nursery (0.85 ± 0.76; P < 0.05). These results suggest that some plasma metabolite phenotypes collected from healthy nursery pigs are moderately heritable and genetic correlations with measures of performance and resilience after disease challenge suggest they may be potential genetic indicators of disease resilience.
Novel implications of a strictly monomorphic (GCC) repeat in the human PRKACB gene
Authors: Khamse Safoura , Jafarian Zahra , Bozorgmehr Ali , Tavakoli Mostafa , Afshar Hossein , Keshavarz Maryam , Moayedi Razieh , Ohadi Mina
Published: October 2021

PRKACB(Protein Kinase CAMP-Activated Catalytic Subunit Beta) is predominantly expressed in the brain, and regulation of this gene links to neuroprotective effects against tau and Aβ-induced toxicity. Here we studied a (GCC)-repeat spanning the core promoter and 5′ UTR of this gene in 300 human subjects, consisting of late-onset neurocognitive disorder (NCD) (N = 150) and controls (N = 150). We also implemented several models to study the impact of this repeat on the three-dimensional (3D) structure of DNA. While thePRKACB(GCC)-repeat was strictly monomorphic at 7-repeats, we detected two 7/8 genotypes only in the NCD group. In all examined models, the (GCC)7 and its periodicals had the least range of divergence variation on the 3D structure of DNA in comparison to the 8-repeat periodicals and several hypothetical repeat lengths. A similar inert effect on the 3D structure was not detected in other classes of short tandem repeats (STRs) such as GA and CA repeats. In conclusion, we report monomorphism of a long (GCC)-repeat in thePRKACBgene in human, its inert effect on DNA structure, and enriched divergence in late-onset NCD. This is the first indication of natural selection for a monomorphic (GCC)-repeat, which probably evolved to function as an “epigenetic knob”, without changing the regional DNA structure.
Graphene oxide/perylene–aniline electrochemiluminescence platform for protein detection based on molecule recognition
Authors: Yin Peng , Zhang Wei , Shang Lei , Ma Rongna , Jia Liping , Wang Huaisheng
Published: October 2021

FA-Poly-dA-ssDNA was attached to the 673 nm-dominated ECL nanomaterial GO/PTCDA-An to fabricate nuclease-free ultrasensitive FR sensors.
Molecular recognition of sialoglycans by streptococcal Siglec-like adhesins: toward the shape of specific inhibitors
Authors: Di Carluccio Cristina , Forgione Rosa Ester , Bosso Andrea , Yokoyama Shinji , Manabe Yoshiyuki , Pizzo Elio , Molinaro Antonio , Fukase Koichi , Fragai Marco , Bensing Barbara A. , Marchetti Roberta , Silipo Alba
Published: October 2021

We here present a detailed molecular description of sialoglycans recognition by Siglec-like adhesins from S. gordonii opening the venue for the design of specific inhibitors to influence the propensity of streptococci to cause infective endocarditis.
Enhanced oxygen evolution activity on mesoporous cobalt–iron oxides
Authors: Tang Tianmi , Zhang Qiaoqiao , Bai Xue , Wang Zhenlu , Guan Jingqi
Published: October 2021

The excellent OER performance of mesoporous cobalt–iron oxides can be due to concerted catalysis between the iron and cobalt sites that lowers the OER energy barrier, and the large specific surface area providing enough active sites.
Bidirectional modulation of microRNA with a clamp-like triplex switch for enhanced and programmed gene therapy
Authors: Zhang Lihua , Zou Zhen , Lei Yanli , Qing Zhihe , Zeng Yu , Sun Haiyan , Feng Feng , Yang Ronghua
Published: October 2021

In this work, a clamp-like triplex switch (CTS) was fabricated for enhanced and programmed gene therapy, which achieved bidirectional modulation of dysregulated microRNA in cancer cells in a controllable manner.
Germatranes and carbagermatranes: (hetero)aryl and alkyl coupling partners in Pd-catalyzed cross-coupling reactions
Authors: Xu Meng-Yu , Xiao Bin
Published: October 2021

The synthesis and Pd-catalyzed cross-couplings of structure-modified (hetero)aryl germatranes and alkyl carbagermatranes have been established.
Synthesis of pyrimido[2,1-a]isoindolone and isoindolo[2,1-a]quinazolinone via intramolecular aza-Prins type reaction
Authors: Biswas Subhamoy , Porashar Bikoshita , Arandhara Pallav Jyoti , Saikia Anil K.
Published: October 2021

An efficient approach for the synthesis of pyrimido[2,1-a]isoindolone and isoindolo[2,1-a]quinazolinone via intramolecular aza-Prins type reaction of N-acyliminium ions and amides in excellent yields is reported.
Simultaneous single-molecule detection of the acetyltransferase and crotonyltransferase activities of histone acetylation writer p300
Authors: Jiang Su , Ren Jingyi , Xu Qinfeng , Zou Xiaoran , Li Yueying , Zhang Chun-yang
Published: October 2021

We demonstrate the simultaneous single-molecule detection of the acetyltransferase (HAT) and crotonyltransferase (HCT) activities of histone acetylation writer p300.
A series of luminescent Cu(i) complexes based on the diphosphine ligand and diimine ligand: weak intermolecular interactions, terahertz spectroscopy and photoproperties
Authors: Li Zi-Xi , Kuang Xiao-Nan , Wang Guo , Zhu Ning , Sun Zhen-Zhou , Han Hong-Liang , Yang Yu-Ping , Li Zhong-Feng , Xin Xiu-Lan , Jin Qiong-Hua , Ren Zhi-Gang
Published: October 2021

Counter-ions can regulate the luminescence of complexes by changing the weak intermolecular interactions, which can be observed by THz spectroscopy.
Experimental and theoretical studies of a pyridylvinyl(benzoate) based coordination polymer structure
Authors: Dezotti Yuri , Barrionuevo Manoel Victor Frutuoso , Silva Ingrid Fernandes , Ribeiro Marcos Antônio , Añez Rafael , Stumpf Humberto Osório , San-Miguel Miguel Angel , Barros Wdeson Pereira
Published: October 2021

The electronic, adsorption and structural properties of a layered coordination polymer formed with 3,4-pvb− and copper(ii) were studied.
Influence of temperature on the equilibria of oxidovanadium(iv) complexes in solution
Authors: Sanna Daniele , Lubinu Giuseppe , Ugone Valeria , Garribba Eugenio
Published: October 2021

The equilibria at different temperatures of VIVOL2complexes were investigated in order to elucidate their interaction with proteins.
Remote control: stereoselective coordination of electron-deficient 2,2′-bipyridine ligands to Re(i) and Ir(iii) cores
Authors: Jerwood Kimberley , Lowy Phoebe , Deeming Laura , Kariuki Benson M. , Newman Paul D.
Published: October 2021

Configurational diastereoselectivity is observed upon coordination of a mono-substituted bipy ligand with an asymmetric amidinium group at the 4-position while no selectivity occurs with the analogous 5-derivative.
In vitro and in vivo inhibition of Helicobacter pylori by Lactobacillus plantarum pH3A, monolaurin, and grapefruit seed extract
Authors: Kang Sini , Guo Yaqing , Rao Junhui , Jin Hui , You Hyun Ju , Ji Geun Eog
Published: October 2021

In vitro and in vivo assessment of inhibitory effects of Lactobacillus strain, monolaurin, and grapefruit seed extract on growth of Helicobacter pylori.
Diosmetin inhibits cell growth and proliferation by regulating the cell cycle and lipid metabolism pathway in hepatocellular carcinoma
Authors: Pan Lianhong , Feng Fan , Wu Jiaqin , Li Lanqing , Xu Haiying , Yang Li , Xu Kang , Wang Chunli
Published: October 2021

DSM, a newly discovered natural flavonoid, found in citrus plants and olive leaves, exhibited antitumor effects on HCC cells by inhibiting cell proliferation via cell cycle arrest and interfering with lipid metabolism.
Correction: A truly bio-based benzoxazine derived from three natural reactants obtained under environmentally friendly conditions and its polymer properties
Authors: Machado Irlaine , Hsieh Isabel , Rachita Eric , Salum Maria L. , Iguchi Daniela , Pogharian Nicholas , Pellot Analisa , Froimowicz Pablo , Calado Veronica , Ishida Hatsuo
Published: October 2021

Correction for ‘A truly bio-based benzoxazine derived from three natural reactants obtained under environmentally friendly conditions and its polymer properties’ by Irlaine Machado et al., Green Chem., 2021, 23, 4051–4064, DOI: 10.1039/D1GC00951F.
Enhancing the performance of hard carbon for sodium-ion batteries by coating with silicon nitride/oxycarbide nanoparticles
Authors: Cheng Hang , Garcia-Araez Nuria , Hector Andrew L.
Published: October 2021

Hard carbon decorated with silicon nitride or silicon oxycarbide nanoparticles was produced from cellulose. The silicon nitride composite showed a high capacity in sodium cells with the capacity linked to surface reduction followed by oxidation.
A facile synthesis of novel polyaniline/graphene nanocomposite thin films for enzyme-free electrochemical sensing of hydrogen peroxide
Authors: Verma Swati , Mal Dipendra Singh , de Oliveira Paulo Roberto , Janegitz Bruno Campos , Prakash Jai , Gupta Raju Kumar
Published: October 2021

The electrochemical method is the most effective, facile, and economical approach for the detection of small molecules.
Computational approaches leveraging integrated connections of multi-omic data toward clinical applications
Authors: Demirel Habibe Cansu , Arici Muslum Kaan , Tuncbag Nurcan
Published: October 2021

Data integration approaches are crucial for transforming multi-omic data sets into clinically interpretable knowledge. This review presents a detailed and extensive guideline to catalog the recent computational multi-omic data integration methods.
Strain engineering and electric field tunability of the electronic properties of a two-dimensional ZnGeN2monolayer
Authors: Do Thi-Nga , Nguyen Son-Tung , Pham D. K.
Published: October 2021

In this work, by means of first-principles calculations, we investigate the structural and electronic properties of a two-dimensional ZnGeN2monolayer as well as the effects of strain and an electric field.
Multi-fold Sonogashira coupling: a new and convenient approach to obtain tetraalkynyl anthracenes with tunable photophysical properties
Authors: Islam Khadimul , Narjinari Himani , Bisarya Akshara , Kumar Akshai
Published: October 2021

Nine new symmetric tetraalkynylated anthracenes have been synthesized via Pd(CH3CN)2Cl2/cataCXium®A catalyzed tetra-fold Sonogashira coupling. Exciting photophysical properties are exhibited by these molecules in solution and in the solid-state.
Transition-Metal-Free Synthesis of Conjugated Microporous Polymers via Amine-Catalyzed Suzuki-Miyaura Coupling Reaction
Authors: Liu Qingmin , Jin Shangbin , Tan Bien
Published: October 2021

The synthesis of conjugated microporous polymers (CMPs) has been heavily relied on transition-metal-catalysis carbon-carbon coupling reactions, which has shortages in the scarcity and high cost of the noble metal catalysts....
Fundamental understanding of electrochemical catalytic performance of carbonized natural wood: wood species and carbonization temperature
Authors: Huang Yao , Song Meiling , Tian Cuihua , Wu Yiqiang , Li Yuyan , Yan Ning , Qing Yan
Published: October 2021

The pore structure and carbonization temperature of wood have a great influence on the electrocatalytic performance of wood carbon. This work is of great significance for the selection of suitable wood carbon substrate materials for electrocatalysis.
The construction of an artificial light-harvesting system with two-step sequential energy transfer based on supramolecular polymers
Authors: Li Xing-Long , Wang Ying , Song Ao , Zhang Ming-Hui , Jiang Man , Liu Hui , Wang Rongzhou , Yu Shengsheng , Xing Ling-Bao
Published: October 2021

An artificial light-harvesting system with two-step sequential energy transfer has been constructed based on supramolecular polymers through host–guest interactions, which can be used for photocatalytic dehalogenation of α-bromoacetophenone.
Correction: Plasmonic Au nanoclusters dispersed in nitrogen-doped graphene as a robust photocatalyst for light-to-hydrogen conversion
Authors: Van Dao Dung , Cipriano Luis A. , Di Liberto Giovanni , Nguyen Thuy T. D. , Ki Sang-Woo , Son Hoki , Kim Gyu-Cheol , Lee Kang Hyun , Yang Jin-Kyu , Yu Yeon-Tae , Pacchioni Gianfranco , Lee In-Hwan
Published: October 2021

Correction for ‘Plasmonic Au nanoclusters dispersed in nitrogen-doped graphene as a robust photocatalyst for light-to-hydrogen conversion’ by Dung Van Dao et al., J. Mater. Chem. A, 2021, DOI: 10.1039/D1TA05445G.
Clinical Experiences of People With a Laryngectomy During the SARS COVID-19 Pandemic
Authors: Searl Jeff , Kearney Ann , Genoa Kathryn , Doyle Philip C.
Published: October 2021

Purpose

This study described the clinical experiences of patients with a total laryngectomy (TL) during the COVID-19 pandemic and identified changes in communication, tracheostoma care, and heat–moisture exchange (HME) use that were recommended or self-implemented.

Method

An online survey addressing the study aims was completed by 173 people with a TL who live in the United States. The survey was open from July 5 to August 10, 2020.

Results

In-person clinic visits, appointment cancellations, and contact from their speech-language pathologists (SLPs) were reported by 42%, 19%, and 54% of the TL respondents, respectively. At clinic visits, 78% were required to wear a mask over their nose/mouth, and 73% were required to wear a mask over their tracheostoma. Masks, gloves, and face shields worn by the SLP at these visits were reported by 84%, 82%, and 70% of the TL patients, respectively. Alaryngeal communication changes were recommended by the SLP for 7%–18% of TL patients, depending on their method of communication, whereas 43%–45% implemented changes on their own. Changes in tracheostoma care and HME use were recommended by the SLP for 27% and 21% of the TL respondents, respectively, whereas 54% and 47% made changes on their own.

Conclusions

Individuals with a TL will require in-person care even during a pandemic, as reflected in this study. Many had not been contacted by their SLP or otolaryngologist about TL guidelines that were becoming available. Notably, larger percentages of TL patients reported self-initiated changes to their communication, tracheostoma care, and HME use because of the pandemic than their SLP had advised. The types of communication changes varied in part, depending on the method of alaryngeal speech a respondent used.

Supplemental Material

https://doi.org/10.23641/asha.16807270
Parker Solar Probe detects solar radio bursts related with a behind–the–limb active region
Authors: Stanislavsky Aleksander A. , Bubnov Igor N. , Koval Artem A. , Yerin Serge N.
Published: October 2021

Context.The interpretation of solar radio bursts observed by Parker Solar Probe (PSP) in the encounter phase plays a key role in understanding intrinsic properties of the emission mechanism in the solar corona. Lower time–frequency resolution of the PSP receiver can be overcome by simultaneous ground–based observations using more advanced antennas and receivers.

Aims.In this paper we present such observations for which the active active region 12 765, begetter of type III, J, and U solar bursts, was within sight of ground–based instruments and behind the solar limb of the PSP spacecraft.

Methods.We used a subarray of the Giant Ukrainian Radio Telescope to get the spectral properties of radio bursts at the frequency range of 8–80 MHz, as well as the PSP radio instruments with a bandwidth of 10.5 kHz–19.2 MHz, during solar observations on June 5, 2020.

Results.We directly detected the radio events initiated by the active region behind the solar limb of the PSP spacecraft, using special conditions in the solar corona, due to the absence of active regions from the PSP side. Following the generation mechanism of solar radio emission, we refined the density model for the solar corona above the active region 12765 responsible for the radio bursts. Based on the PSP spacecraft position near the Sun and delays of radio waves between space– and ground–based records, we found the corresponding radio responses on the PSP spectrogram.

Conclusions.The absence of sunspots from the PSP side contributes to the propagation of radio waves from a dense loop of the Sun to quiet regions with low densities, through which PSP instruments can detect the radiation.
Features of design solutions in the design of a special-purpose building of urban infrastructure
Authors: Filimonova Larisa , Matys Elena , Skvortsova Nadezhda
Published: October 2021

The article discusses approaches to the formation of the optimal combination of design solutions in the construction of a building for funeral services. The projected facility fulfills a triple purpose: social, communal and industrial. The industrial purpose is due to the peculiarities of the assembled technological equipment and its maintenance. These are the parameters of the crematorium construction project. The contradiction in the purpose of the building can be traced in the architectural solution, the decision on the choice of engineering communications and the transport and logistics infrastructure of the environment of the object. What the authors pay attention to in their publication. The classical task of substantiating a design solution is the formation of a single information space of a capital construction object, taking into account information reflecting all stages of its life cycle. The principal distinguishing feature of the research results is the prepared set of key characteristics of the formation of project documentation, taking into account the functional parameters of the specific purpose of the projected capital construction facility, the relevance of which is undeniable both from an environmental point of view and from the standpoint of socializing society and preventing religious fanaticism.
Eco-labeling is a useful piece of informational metabolism in the youth environment
Authors: Khabarova E. I. , Nikitina S. V. , Strebkova M. V.
Published: October 2021

Environmental awareness of consumers and the popularity of a healthy lifestyle are the trends of our time both in the world and in Russia. The article discusses the ecolabelling sign as a means of offline information about the environmental characteristics of products and an important criterion when choosing and buying various goods. In our country, there are only prerequisites for an approach to greening business and positioning "environmentally friendly" products. However, it is vital that everyone understands the eco-label and distinguishes the certificate of declared quality from the marketing ploy. The paper touches upon the issues of ecological education and formation of the population ecological culture. To clarify the importance of eco-labeling in the formation of an environmentally oriented lifestyle among young people, a sociological research method was used, suitable for clarifying any aspects of social relations and capable of providing operational primary sociological information. The results of the survey of the 1st and 2nd year students of the Moscow State University of Fine Chemical Technologies named after M.V. Lomonosov in 2019/2020 academic year, concerning their interest in the environmental characteristics of the purchased goods, are provided.
China’s green insurance system and functions
Authors: Belozyorov Sergey A. , Xie Xiaohe
Published: October 2021

The article aims at the relationship between China’s green insurance, social and economic development, and environmental protection. It analyzes China’s green insurance development measures and operating mechanism. According to the China Statistical Yearbook, based on data from 2011-2019, research variables are selected for empirical analysis and qualitative analysis. It is concluded that the green insurance industry is conducive to sustainable and sustainable development, reduces industrial transformation risks, improves environmental protection capabilities, and improves residents’ living standards. China’s experience in developing the green insurance industry provides a useful reference for the sustainable development and development of green finance in developing countries and regions.
Ecological and radiation safety of Central Asia
Authors: Yurov Victor , Eremin Evgeniy , Guchenko Sergey
Published: October 2021

Previous calculations showed that in the Kyrgyz Republic 7.2% of the total population are exposed to the “radiation risk”, in the Republic of Kazakhstan - about 3%, in the Republic of Tajikistan - 1.7% and in the Republic of Uzbekistan - 0.3%. The number of radiation-contaminated territories in the Republics of Central Asia is equal: the Kyrgyz Republic contains about 132 million m3 of waste, the Republic of Tajikistan contains about 180 million m3 of waste, the Republic of Uzbekistan contains 640 million m3 of waste, and the Republic of Kazakhstan contains approximately 10,000 million m3 of waste. Total: in the four Republics of Central Asia, the total amount of radioactive waste is 10952 million m3. Taking as a basis the limited liability company “Vismut GmbH” from Germany, which carried out the reclamation of uranium tailings with a volume of 160 million m3 of tailings at a cost of about 8 billion euros for about 37 years. Using a thermodynamic approach, it is shown that the costs of reclamation of uranium tailings for the four Central Asian Republics will be 548 billion euros, and the duration will be about 40 years.
Applying a consulting system in the management of construction companies’ interactions
Authors: Selyutina Larisa , Pesotskaya Elena , Ivanova Maria , Maleeva Tatiana
Published: October 2021

The article reveals the interaction system features of construction companies, substantiates the need to introduce special management means into the organizational and management practice of construction companies, which include management consulting. The features of management consulting, its methodology and methods are considered. The author’s approach to the formation of managerial decisions in the system of interactions between construction companies, focused on the implementation of the principle of joining internal and external consultants’ efforts within the framework of combined consulting, is stated. It is shown that combined consulting acts as universal mean that provides a full suite of services in management, creating preconditions for the successful implementation of the principles of the concept of interaction in the management of construction companies, and is the most important factor that activates the construction companies’ interaction with the subjects of the regional investment and construction market.
Problems of residential migration in the framework of the formation of “smart agglomeration”
Authors: Asylbayev Aidar , Niiazalieva Kunduzkul , Brovko Natalia , Borbugulov Malik
Published: October 2021

The relevance of the work is in solving problems arising from the disproportionate development of migration flows and natural and technical resources. The paper examines the development of migratory residential areas in the context of the need to form an integral system of smart satellite cities around the capital – Bishkek city. There is also a study of the environmental and social problems that arise due to the lack of a systematic approach to the management of the city and its satellites. The existing today, numerous individual housing buildings around the capital cause a serious problem for the rational use of environmental and engineering resources and balanced demographic development of the whole country. To solve the impending problems, it is recommended to build a fundamentally new model of an urban and environmentally friendly agglomeration. Thus, the purpose of the article is to identify problems among new immigration residential buildings and rationale for the need to build city-forming “smart zones of urban development” with a control center in Bishkek. Conclusions and recommendations are given for the government and administrative services of the Kyrgyz Republic.
Development of human potential as an important condition of the economic security of the enterprise
Authors: Gomeleva Ekaterina Viktorovna , Ripoll-Saragosi Lyudmila Gennad’evna , Kokhanova Viktoriia Sergeevna , Grigorieva Natalia Stanislavovna
Published: October 2021

The main concept of the study is based on the study of human potential as one of the conditions for the economic security of an enterprise. The article considers the theoretical aspects of human potential, describes the subject of human potential, reveals assessment tools and factors influencing its human development. The most significant potential threats that directly affect the development of human potential are indicated, including: the risk of burnout of employees working remotely, the prevalence of relatively directive management methods at the level of line managers of the enterprise. The ways of overcoming the existing problems are proposed, the solution of which will influence the development of human potential.
Personnel training in Russia: response to modern challenges and threats in the context of digitalization of the economy
Authors: Gretchenko Anatoly , Gretchenko Alexander
Published: October 2021

The article discusses the results of a study conducted at the Research Institute “New Economics and Business” of the Plekhanov Russian University of Economics. University science, the system of university research is a modern form of integration of science and digital technologies. The development of the research methodology and the transformation of personnel training for the Russian economy, taking into account the emerging risks and threats to business, society and the state, is one of the priority areas of university research. The rapid development of digital technologies not only opens up opportunities for achieving the goals of sustainable socio-economic development, but also creates threats and risks, including of an ethical nature. It allows us to link positive trends and the growth of sustainable development from the widespread use of digital resources, tools and technologies, as well as possible risks and threats associated with it. According to the authors, the answer to the risks and threats that have arisen can only be a deep complex transformation of the entire domestic personnel training system. Only a digital educational ecosystem is able to form a modern specialist with high adaptability and self-learning. The circumstances considered in the article determine the relevance of such studies and indicate the need for digital transformation of personnel training for the Russian economy in the current socio-economic conditions.
Die „Big Five“ der Invasivität – Sinnhaftigkeit von Drainagen, Sonden und Kathetern in der kolorektalen Chirurgie
Authors: Koch Franziska , Green Martina , Dietrich Melanie , Moikow Lutz , Ritz Jörg-Peter
Published: October 2021

Das perioperative Management bei kolorektalen Resektionen ist häufig durch tradierte Vorgehensweisen und ausgeprägtes Sicherheitsdenken gekennzeichnet. Evidenzbasierte Maßnahmen, wie sie in
Fast-Track- oder ERAS-Programmen etabliert wurden, werden hingegen seltener standardisiert angewandt. Viele Patienten erhalten daher im Rahmen elektiver kolorektaler Chirurgie weiterhin
routinemäßig zentralvenöse Zugänge, Periduralkatheter, Blasenkatheter, Drainagen und/oder Magensonden („Big Five“ der Invasivität). In dieser Arbeit wird die aktuell vorhandene Evidenz zu
diesen Maßnahmen in der kolorektalen Chirurgie dargestellt. Zudem werden Ergebnisse mit Bezug zu den „Big Five“ aus dem eigenen Zentrum vorgestellt. Diese Arbeit zeigt auf, dass die „Big
Five“ der Invasivität klinisch nicht erforderlich und mit fehlender Evidenz belegt sind. Zudem führen sie häufig zu einer Einschränkung des Patienten.
Behandlung und Therapieerfolg in der forensischen Psychiatrie
Authors: Schiltz Kolja , Falkai Peter
Published: October 2021

In dieser Ausgabe werden drei wichtige Artikel zur psychiatrischen Behandlung von Straftätern publiziert. Vor dem Hintergrund, dass die Anzahl der forensisch-psychiatrischen Behandlungsplätze für Personen, die im Kontext einer psychiatrischen Erkrankung eine Straftat begangen haben, in Deutschland seit vielen Jahren stetig anwächst, ist es sehr wichtig, dass die Entwicklung dieses Bereiches, nämlich der forensischen Psychiatrie, stetig durch wissenschaftliche Forschung überprüft und geleitet wird. Die drei Artikel in dieser Ausgabe adressieren zum einen die wissenschaftliche Situation hinsichtlich belegter Wirkfaktoren in der Behandlung von Straftätern und zum anderen Faktoren, die die Erfolgswahrscheinlichkeit einer Behandlung von suchtkranken Straftätern vorhersagen.
Systematische Übersichtsarbeit: aortale Komplikationen nach intravesikaler Bacillus Calmette-Guérin-Behandlung
Authors: Buerger Matthias , Kapahnke Sebastian , Omran Safwan , Müller Verena , Hinterseher Irene , Greiner Andreas , Frese Jan Paul
Published: October 2021

Hintergrund Aortale Pathologien nach intravesikaler
BCG-Applikation (BCG: Bacillus Calmette-Guérin) stellen eine
seltene Komplikation nach der Behandlung von nicht muskelinvasiven Harnblasentumoren dar. Das
Ziel dieser Studie war es, eine deskriptive Analyse der bisher publizierten Studien im Rahmen
einer systematischen Übersichtsarbeit durchzuführen und die besonderen Herausforderungen der
Diagnosestellung und Behandlung dieser seltenen Komplikation zu diskutieren.

Material und Methode Es erfolgte eine Literaturrecherche in den
Datenbanken PubMed (1949–2021) und Web of Science (1900–2021) mit den Suchtermini
„mycobacterium“ OR „bovis“ OR „BCG“ AND „aorta“ OR „aneurysm“. In einem stufenweisen
Bewertungsverfahren wurden Publikationen mit folgenden Einschlusskriterien in die finale
Datenauswertung eingeschlossen: Originalarbeit, Volltextverfügbarkeit in englischer oder
deutscher Sprache und aortale Komplikation nach intravesikaler BCG-Instillation.

Ergebnisse In 55 publizierten Arbeiten wurden insgesamt 60
Einzelfälle beschrieben. BCG-induzierte, mykotische Aortenaneurysmen können in allen Segmenten
der Aorta auftreten, wobei das infrarenale Aortensegment am häufigsten betroffen war (65%
aller Fälle). Häufig handelte es sich um sakkuläre (65%) Aussackungen mit (28%) oder ohne
Aortenruptur (63%). Begleitinfektionen in anderweitigen Geweben waren typisch (65%). Die
Diagnose beruhte auf der Kombination aus pathologischen und mikrobiologischen Analysemethoden.
Ein gängiger Therapiealgorithmus war die chirurgische Infektsanierung (85%) und die
antimykobakterielle Therapie (83%). Gleichzeitig durchgeführt führten sie zu einem
Langzeitüberleben von 81%. Eine Protheseninfektion nach initialem Aortenrepair mit
alloplastischem Material (n = 40) entwickelte sich im Verlauf bei 10 Patienten (25%).

Diskussion Die Diagnosestellung beruht auf der Probengewinnung
jeglichen infizierten Gewebes und der Kombination aus passender Anamnese, Klinik und
Laboranalysen. Die Kombination aus chirurgischer Infektsanierung und pharmakologischer
Begleittherapie scheint die besten Ergebnisse zu erzielen. Bereits bei der Initialoperation
sollte die Möglichkeit eines autologen oder allogenen Aortenersatzes evaluiert werden, da das
Risiko eines Protheseninfektes nach Verwendung alloplastischer Materialien hoch ist.
Surgeon-modified Stentgrafts für komplexe Aortenrekonstruktionen – was ist möglich?
Authors: Geisler Antonia , Steiner Sabine , Schmidt Andrej , Scheinert Dierk , Branzan Daniela
Published: October 2021

Hintergrund Die enge anatomische Beziehung zu den Viszeralgefäßen macht die Behandlung der komplexen thorakoabdominellen Aortenpathologien zu einer Herausforderung. Im Notfall stehen zu ihrer endovaskulären Behandlung Off-the-Shelf-Prothesen und parallele Techniken zur Verfügung, alternativ kann für komplexe Aortenanatomien die Modifizierung herkömmlicher Stentgrafts durch die behandelnden Chirurginnen und Chirurgen erfolgen, im Sinne eines Surgeon-modified Stentgrafts (SMSG). Ziel der vorliegenden Publikation ist die Darstellung der Möglichkeiten und Ergebnisse, die dieses Verfahren bietet.

Ergebnisse Die Planung der Fenestrierungen des SMSG kann mittels manueller Messungen in Centerline of Flow-Rekonstruktionen der aortalen Computertomografie-Angiografie erfolgen. Vereinfacht und standardisiert wird die Planung des SMSG durch die Erstellung von personalisierten 3-D-Aortenmodellen und die Entwicklung von Algorithmen zur automatisierten Ermittlung der idealen Fenestrierungspositionen. Zur Herstellung des SMSG können die meisten zugelassenen Stentgrafts verwendet werden. Für die Anfertigung selbst sind unterschiedliche Techniken beschrieben. Außer der einfachen Fenestrierung ist auch die Erstellung von Mini-Cuffs, Directional Branches und Inner Branches beschrieben, weiterhin die Ergänzung von Diameter reducing Ties und das Vorladen von Führungsdrähten zur Erleichterung der Implantation. Die Behandlung mit SMSG zeigt gute Ergebnisse mit hohen technischen Erfolgsraten um 90–100% und niedriger 30-Tage-Mortalität, vor allem im Vergleich zur
offen-chirurgischen Behandlung ähnlicher PatientInnen. Auch die Rate an Endoleaks ist mit 0–14% akzeptabel. Langzeitergebnisse zur Nachhaltigkeit der modifizierten Stentgrafts sind bislang noch nicht verfügbar.

Schlussfolgerung Die Surgeon-modified Stentgrafts stellen eine sichere und machbare Ergänzung der Palette endovaskulärer Behandlungsoptionen für PatientInnen mit dringlichen komplexen thorakoabdominellen Aortenpathologien dar. Sie können im Rahmen eines individuellen Heilversuches eingesetzt werden und zeigen in der Literatur vielversprechende Ergebnisse.
Photoredox-Catalyzed Ring-Opening Addition Reaction between Benzyl Bromides and Cyclic Ethers
Authors: Hu Jinbo , Kuang Cuiwen , Ni Chuanfa , Gu Yucheng
Published: October 2021

A novel nucleophilic reaction between cyclic ethers and benzyl bromides is achieved under photoredox catalysis. The reaction proceeds through a single-electron-transfer (SET) pathway rather than a common SN2 mechanism. By two steps of reduction and oxidation, a benzyl bromide heterolyzes to give a carbocation and bromide ion under mild conditions, and then a cyclic ether captures both the carbo­cation and bromide ion to afford the addition product.
Tandem Nickel-Catalyzed Dimerization/(4+2) Cycloaddition of Terminal Alkynes with Four-Membered Ring Ketones
Authors: Aïssa Christophe , Barday Manuel , Nicolas Eva , Higginson Bradley , Delmotte François , Appelmans Martin
Published: October 2021

Controlling the behavior of terminal alkynes in metal-catalyzed intermolecular tandem reactions is a formidable challenge despite the potential advantage offered by these strategies in modern synthesis. Herein, we describe that a nickel catalyst enables a tandem process involving the rapid dimerization of terminal alkynes into 1,3-enynes and the cycloaddition of these intermediates with an azetidinone, an oxetanone or benzocyclobutenones. Significantly, the slow or sequential addition of reagents and catalysts is not required to orchestrate their reactivity. These results are in stark contrast with previous cycloadditions of terminal alkynes with strained four-membered ring substrates, which previously led to oligomerization or cyclotrimerization, except in the case of tert-butylacetylene.
Novel Benzothiophene-Based Fluorescent Dye Exhibiting a Large Stokes Shift
Authors: Kaskova Zinaida M. , Bolt Yaroslav V. , Baleeva Nadezhda S. , Nelyubina Yulia V. , Andrianova Anastasia A. , Tsarkova Aleksandra S.
Published: October 2021

We report a simple two-step method for the synthesis of a novel highly fluorescent benzothiophene-based dye comprising five fused rings and exhibiting a large Stokes shift (Δλ = 152 nm or Δν = 5482 cm–1 in ethanol). Structural features of the obtained compound allow easy functionalization of the carbon core and open new possibility for the development of a series of new classes of fluorescent dyes.
A Systematic Approach to Reconciling Data Quality Failures: Investigation Using Spinal Cord Injury Data
Authors: Anantharama Nandini , Buntine Wray , Nunn Andrew
Published: October 2021

Background Secondary use of electronic health record's (EHR) data requires evaluation of data quality (DQ) for fitness of use. While multiple frameworks exist for quantifying DQ, there are no guidelines for the evaluation of DQ failures identified through such frameworks.

Objectives This study proposes a systematic approach to evaluate DQ failures through the understanding of data provenance to support exploratory modeling in machine learning.

Methods Our study is based on the EHR of spinal cord injury inpatients in a state spinal care center in Australia, admitted between 2011 and 2018 (inclusive), and aged over 17 years. DQ was measured in our prerequisite step of applying a DQ framework on the EHR data through rules that quantified DQ dimensions. DQ was measured as the percentage of values per field that meet the criteria or Krippendorff's α for agreement between variables. These failures were then assessed using semistructured interviews with purposively sampled domain experts.

Results The DQ of the fields in our dataset was measured to be from 0% adherent up to 100%. Understanding the data provenance of fields with DQ failures enabled us to ascertain if each DQ failure was fatal, recoverable, or not relevant to the field's inclusion in our study. We also identify the themes of data provenance from a DQ perspective as systems, processes, and actors.

Conclusion A systematic approach to understanding data provenance through the context of data generation helps in the reconciliation or repair of DQ failures and is a necessary step in the preparation of data for secondary use.