bluuebunny/crossref_metadata_2025 huggingface dataset:
A nomogram for predicting survival in patients with upper limb melanoma: A study based on the Surveillance, Epidemiology, and End Results database
Authors: Dong Zhiqin , Zhang Jinrong , Li Zehua
Published: January 2024

Introduction:
In order to predict cancer-specific survival (CSS) in patients with upper limb melanoma (ULM) at three-, five-, and eight-year intervals following diagnosis, a nomogram was developed and validated in this study.
Methods:
Patient data about the upper limb melanoma (ULM) cases were collected from the comprehensive Surveillance, Epidemiology, and End Results (SEER) database. A training cohort consisting of 70% of the patient population and a validation cohort comprising 30% of the patients were established through a random selection process. A stepwise backward Cox regression model was employed to identify independent prognostic variables. The nomogram was then updated to integrate these factors, making it possible to estimate the rates of cancer-specific survival (CSS) after 3, 5 and 8 years after diagnosis. A number of metrics were used to assess the nomogram's performance, including the calibration curves, decision-curve analysis (DCA), net reclassification improvement (NRI), concordance index (C-index), integrated discrimination improvement (IDI), and the area under the time-dependent receiver operating characteristic curve (AUC).
Results:
This study involved a comprehensive cohort comprising 36,621 patients diagnosed with upper limb melanoma (ULM). Through an analysis of the Cox regression model within the training cohort, a total of 13 prognostic factors were identified, namely age, RNP (regional node positive), sex, race, marriage, AJCC (American Joint Committee on Cancer) stage, surgical status, radiation status, chemotherapy status, income status, survival time and current status. An extensive set of internal and external validation processes were then applied to the development of a nomogram. The nomogram demonstrated excellent discriminatory abilities, as reflected by significantly high C-index and AUC values. Calibration curves provided further confirmation of the nomogram's reliability. Notably, the nomogram exhibited superior performance compared to the AJCC model, as evidenced by improved NRI and IDI values. The decision-curve analysis (DCA) curves further validated the clinical utility of the nomogram, underscoring its practical relevance in prognostication for patients with ULM.
Conclusions:
The current investigation has effectively developed and validated an initial nomogram for prognosticating outcomes in patients with upper limb melanoma (ULM). The nomogram's impressive performance and practical applicability highlight its potential usefulness within clinical settings. However, it is important to note that additional external validation is necessary to further substantiate its reliability and generalizability.
Revealing Distinctive Insights: Machine Learning-Enhanced Ensembled MRI Sequences for Pediatric Posterior Fossa Tumor Classification
Authors: Ünalan Serhat , Onat Fatih Ekrem , Şahin Feyza , Keserci Bilgin
Published: January 2024

Pediatric posterior fossa (PF) tumors pose a significant concern in pediatric oncology because of their high prevalence in the pediatric population. Magnetic Resonance Imaging (MRI) has emerged as a practical and non-invasive imaging modality for detecting and classifying PF malignancies. For the differentiation of MB, the LGBM model, using the feature combination of T2, FLAIR, DWI, and ADC, demonstrated the highest performance. It achieved an AUROC of 0.938, accuracy of 0.778, specificity of 0.916, sensitivity of 0.645, and F1 score of 0.664. In the classification of EP, the XGB model, which utilizes the feature combination of T2 and DWI, demonstrated the highest performance with a sensitivity of 1. With respect to the distinction of PA, the RF model, using the feature combination of T2, T1CE, DWI, and ADC, exhibited the highest performance. For the classification of BG, the RF model, using the feature combination of T2, DWI, and ADC, exhibited the highest performance. This comprehensive approach has notably enhanced our comprehension of pediatric PF tumor classification and carries substantial potential for the advancement of diagnostic tools and the refinement of ML models.
A Modal Fusion Network with Dual Attention Mechanism for 6D Pose Estimation
Authors: Wei Liangrui , Xie Feifei , Sun Lin , Chen Jinpeng , Zhang Zhipeng
Published: January 2024

The 6D pose estimation based on RGB-D data holds significant application value in computer vision and related fields. Currently, deep learning methods commonly employ convolutional networks for feature extraction, which are sensitive to keypoints at close distances but overlook information related to keypoints at longer distances. Moreover, in subsequent stages, there is a failure to effectively fuse spatial features (depth channel features) and color-texture features (RGB channel features). Consequently, this limitation results in compromised accuracy in existing 6D pose networks based on RGB-D data. In addressing this issue, this paper proposes a novel end-to-end network. Specifically, in the depth value extraction branch, a mask vector attention mechanism is used to establish global spatial weights, achieving robust extraction of depth values. In the fusion stage, a symmetrical fusion module is introduced, which utilizes a cross-attention mechanism to integrate spatial features and color-texture features, enhancing the efficiency of target representation and achieving self-correlated fusion between modalities, thereby effectively improving the accuracy of 6D pose estimation. Experimental evaluations were conducted on the LINEMOD and LINEMOD-OCLUSION datasets, and the results indicate that the proposed method achieved ADD(-S) scores of 95.84% and 47.89%, respectively. Compared to state-of-the-art methods, our approach demonstrates superior performance in pose estimation for objects with complex shapes. Moreover, in the presence of occlusion, the accuracy of pose estimation for asymmetric objects has been effectively improved.
Association of dietary patterns with anxiety and depressive symptoms during pregnancy: a cross-sectional study
Authors: Yang Rusi , Yang Panzi , Luo Yangzhenlin , Zhang Yixin , Xie Zhaolong , Hu Ming , Yang Guilian
Published: January 2024

Background
Dietary intake plays a significant role in mental health. Our objective was to examine the association of dietary patterns (DPs) with anxiety and depressive symptoms in pregnant women.
Methods
This study was a cross-sectional study conducted in Hunan Province. Food frequency questionnaire, Self-rating Anxiety Scale and the Edinburgh Postnatal Depression Scale were used. Dietary patterns were identified through the utilization of factor analysis. The correlation analysis employed logistic regression.
Results
The detection rates of anxiety and depression symptoms during pregnancy were 16.8% and 51.3%, respectively. We have identified five DPs in this study. After accounting for possible confounding factors, a positive correlation was found between DP3 and the risk of anxiety (T3:T1, OR = 1.637, 95%CI:1.064–2.519). However, no significant correlations were observed between DP1, DP2, DP4, or DP5 and anxiety symptoms. Additionally, a positive correlation was identified between DP1 and the risk of depression (T3:T1, OR = 1.483, 95%CI: 1.046–2.104). While no significant associations were found between DP2, DP3, DP4 or DP5 and depressive symptoms.
Conclusions
This study indicates that the dietary pattern high in processed meats, fried foods, sweets, desserts, instant noodles, snacks, and pickled vegetables may potentially elevate the risk of anxiety during pregnancy. The dietary pattern dominated by milk and its products, eggs and nuts may increase the risk of depression during pregnancy.
Usefulness and social impact of Minimum Income Schemes against poverty in Spain
Authors: Albarracín Daniel
Published: January 2024

Social assistance policies, such as minimum incomes, occupy a marginal place in welfare policies, as they are not linked to real wage contributions. These social protection schemes were developed as solutions of last resort, providing minimum social protection below the poverty line. They have served in several cases the public image of governments and have been used to achieve some political differentiation with other administrations, regional or central, seen as adversaries.
In this article, from a public policy evaluation approach, we analyse the evolution, usefulness, coverage, and social impact of the Minimum Insertion Income in Andalusia (RMISA), for the years 2018–2021. We examine its characteristics and impact and compare it with other analogous European social benefits and, more specifically, with other significant Spanish autonomous regional incomes. From the outset, the benefit was designed with a complex application and award procedure, and the regional government provided the programme with a meagre budget. In this period, from 2020 onwards, the implementation of the Minimum Vital Income, by the central government, became the ideal pretext to reduce this budget even further, avoiding a significant mutual reinforcement of both incomes and widening the gap between their application and their theoretical objectives.
JEL Clasification: I38 Government Policy; Provision and Effects of Welfare Programs, A14 Sociology of Economics, I320 Measurement and Analysis of Poverty
Declining global sensitivity of stomatal conductance to photosynthesis
Authors: Leng Jiye , Chen Jing M. , Li Wenyu , Luo Xiangzhong , Xu Mingzhu , Rogers Cheryl , Yan Yulin
Published: January 2024

Terrestrial ecosystems play a pivotal role in mitigating climate change through photosynthesis and transpiration regulated by plant stomata. Terrestrial biosphere models (TBMs) commonly couple a biochemical photosynthesis model, i.e., the Farquhar model, and a semi-empirical stomatal conductance model, i.e., the Ball-Berry model, to estimate gross primary productivity (GPP) and evapotranspiration (ET). However, the key ecosystem parameters (i.e., maximum carboxylation rate Vcmax and the Ball-Berry slope m) are commonly prescribed as constant in TBMs, hindering accurate quantification of global GPP and ET. m depicts ‘compromise between the costs and benefits of stomatal conductance relative to the photosynthetic activity of the leaf’, namely the sensitivity of stomatal conductance to photosynthesis. However, although recent work has retrieved continuous seasonal V_cmax over the globe, there is a lack of an effective method to derive spatially and temporally explicit m in TBMs. In this study, we estimated monthly m through a Bayesian parameter optimization approach at 136 eddy covariance flux sites (809 site years) and upscaled site-level m to global gridded m during 2001-2020 via a machine learning model. We found a significant declining trend of global m (R2 = 0.72, P < 0.001) in 2001-2020. We found the largest decline of m in grassland (0.04 per year), moderate declines in deciduous broadleaf forests, mixed forests, and cropland (0.02 per year), the smallest decline in evergreen needleleaf forests and savannas (0.01 per year). We found the air temperature plays the predominant role in driving the declining trend of m. This study generates and analyzes a global timeseries of m by ‘handshaking’ the measured fluxes, terrestrial biosphere models, and remote sensing. Our results highlight the changing relationship between photosynthesis and stomatal conductance under climate change and identify the importance of incorporating m as a dynamic parameter in future GPP and ET simulations with terrestrial biosphere models.
Monitoring Social Networking Platforms to Detect and Filter Fake News using Ensemble Learning
Authors: Zaheer Khurram , Talib Muhammad Ramzan , Hanif Muhammad Kashif , Sarwar Muhammad Umer
Published: January 2024

Social networking platforms and news blogs are providing information to the public. Different business, political, and educational communities rely on these news sources for strategic decision-making. It is straightforward to quickly manipulate and spread real digital news to spread misinformation among communities to get a few benefits or relief. Therefore, an automated system is vital that can detect fake news early during monitoring before it is published online. Several studies have been conducted to detect fake news, focusing on resource-rich languages (mostly English). Because of a lack of annotated corpora, resource-poor languages such as Urdu have not been studied. The objective of this study is to provide an effective method for fake news detection from social media platforms in Urdu. Therefore, in this study, we propose a four-level methodology and perform extensive experiments to find out the best model for fake news detection from social media contents in Urdu. This study proposes a public corpus of Urdu news articles and a methodology for detecting early Urdu fake news. We apply eight machine learning and ensemble learning techniques to three Urdu news corpora. Our experiments show that Bagging with Decision Tree as base learner outperforms the others and obtained F-measure scores of 80.9% on UFN, 84.2% on BET, and 86.02% on FNAC.
Constant-head step-injection tests using a conventional straddle-sliding-packer system for investigating the shear compliances of minor faults
Authors: Ishii Eiichi
Published: January 2024

Low-permeability rock is suitable as the host rock of an underground repository for radioactive waste disposal; however, minor faults might develop there. Investigating the shear compliance of those faults is crucial because they could be elastically sheared by the thermal effect of the waste to damage the waste’s engineered barriers. This study performed constant-head step-injection tests along with a recently developed packer-pressure-based extensometer method for assessing the applicability of this method to investigate the shear compliance of minor faults. Herein, two neighboring minor faults (A and B) in siliceous mudstone were evaluated. The results showed that fault A, with centimeter-thick fault breccia, exhibited high shear compliance, whereas fault B, with millimeters or less-thick fault breccia, displayed low shear compliance despite containing an incohesive fault rock. An elastic shear displacement occurred for fault A during injection and reached 15–66 mm when the test-section pressure increased from 4.1 MPa to 4.3 MPa. Here, the shear compliance was 101mm/MPa or more. Conversely, fault B had cohesion, and shear displacement was undetected even when the test-section pressure increased from 4.0 MPa to 6.0 MPa. In this case, the shear compliance was 10− 1mm/MPa or less. The estimated shear compliances were consistent with the results from previous shear experiments, and therefore, the applied method helps investigate the shear compliances of minor faults.
Survival outcomes following interval versus primary debulking surgery in advanced epithelial ovarian cancer: A retrospective cohort study in Lagos, Southwest Nigeria
Authors: OKUNADE Kehinde SHARAFADEEN , Adekanye Temitope V. , Osunwusi Benedetto , Soibi-Harry Adaiah , Okoro Austin C. , Toks-Omage Eselobu , Okunowo Adebola A. , Ohazurike Ephraim O. , Anorlu Rose I.
Published: January 2024

Background: There is conflicting evidence regarding the survival benefit of interval debulking surgery (IDS) compared to conventional treatment with primary debulking surgery (PDS) in women with advanced epithelial ovarian cancer (EOC).
Objectives: We compared the survivals following PDS followed by adjuvant chemotherapy (ACT) versus IDS after neoadjuvant chemotherapy (NACT) in women with advanced EOC at the gynaecological oncology unit of a tertiary referral centre in Lagos, Southwest Nigeria.
Methods: The data of 126 women with advanced EOC who had standard treatment with either PDS and ACT or NACT and IDS between January 2008 and December 2017 were analyzed. Kaplan-Meier estimates of progression-free (PFS) and overall survival (OS) time stratified by the types of upfront debulking surgery were calculated and compared by employing the log-rank test statistics. Cox proportional hazard models were then used to estimate hazard ratios of the association between the type of surgical debulking and survivals while adjusting for all necessary covariates.
Results: We recorded no statistically significant differences in PFS (adjusted hazard ratio=1.28, 95% confidence interval 0.82–2.01, P=0.282) and OS (adjusted hazard ratio=1.23, 95% confidence interval 0.68–2.25, P=0.491) between IDS and PDS among women with advanced EOC.
Conclusions: There is a need for a larger prospective multicenter study to further compare the impact of upfront surgical debulking types on the survival of women with advanced EOC in our setting. In the meantime, giving interval debulking surgery after a few courses of neoadjuvant chemotherapy should be an acceptable standard of care for women with advanced EOC.
Ultrasound criteria of extra-nodal extension in papillary thyroid cancer metastases and its clinical signifcance
Authors: Parshin V. S. , Garbuzov P. I. , Polkin V. V. , Kupriyanova E. I. , Isaev P. A. , Ivanov S. A. , Kaprin A. D.
Published: January 2024

The purpose of the research was to identify ultrasound criteria of extranodal extension (ENE) in metastases of papillary thyroid cancer and to evaluate the clinical significance of ENE.

Material and Methods. Ultrasound signs of ENE in 283 cervical lymph node metastases from papillary thyroid cancer were analyzed. Extranodal extension in 137 metastases was diagnosed by ultrasound and verified by histological examination. Micrometastases invisible on ultrasound were detected in 144 patients; metastases located inside the organ were detected in 147 patients; metastases located outside the organ were revealed in 136 patients; the size of 98 metastases was less than 1 cm; the size of 185 metastases was more than 1 cm; the age of 51 patients was under 55 years; 132 patients were older than 55 years. Diagnostic significance of ENE and its clinical significance were estimated according to χ2 Pirson criteria.

Results: Two ultrasound criteria: shape change and blurred margins of metastases indicated the presence of ENE. The small number of ultrasound false-negative findings indicated the need for further research. The number of micrometastases not detected by ultrasound was 2-fold higher in patients who had metastases with ENE than in patients who had metastases without ENE. The number of patients with ENE in metastases inside the organ (T1a, T1b, T2 and T3b) was 2.7 times lower compared to patients with metastases developed outside the organ (T3a, T4a, T4b); ENE was observed in metastases of different size and did not depend on age groups.

Conclusion. The ultrasound method allows intravital detection of ENE in metastases of papillary thyroid cancer. The extension is accompanied by a significantly high number of micrometastases in the neck tissue. It is detected more often in metastases located outside the organ, regardless of the size and age of the patients. The extra-nodal extension should be considered as a criterion for an unfavorable prognosis.
Diagnostic value of ICG for sentinel lymph node mapping in patients with stage I endometrial cancer
Authors: Alimov V. A. , Skugarev S. A. , Grekov D. N. , Novikova E. G. , Lantsov D. S. , Danilov A. M. , Sazhina A. V. , Afanasova P. N.
Published: January 2024

Background. Lymphatic spread is the main route of metastasis in early stage endometrial cancer. Considering its significance, three risk factors of lymph node metastasis were identified. At a high risk of lymph node metastasis in patients with stage I endometrial cancer, pelvic and lumbar lymph node dissection is recommended. In low-risk patients, lymph node dissection is not performed. Lymph node dissection in medium-risk patients is considered as a staging procedure. However, in patients with aggravating factors that prevent extended hysterectomy, lymph node biopsy with ICG mapping and subsequent microstaging may be an alternative to lymph node dissection. Purpose of the study: to analyze the effectiveness of surgical approaches for staging endometrial cancer at different risk factors for lymphatic metastasis.

Material and Methods. The treatment outcomes were retrospectively analyzed in 565 patients with stage I endometrial cancer treated at the gynecological oncology department of Botkin City Clinical Hospital and at the gynecological oncology department of Kaluga Regional Clinical Oncology Center from 2021 to 2023. All women were divided into three groups according to the risk factors of lymph node metastasis. Patients underwent hysterectomy, hysterectomy combined with pelvic or pelvic and lumbar lymphadenectomy, as well as hysterectomy with ICG mapping and sentinel lymph node biopsy.

Results. A total of 334 endometrial cancer patients underwent surgery at Botkin City Clinical Hospital. In the medium-risk group patients (n=94), who underwent hysterectomy with pelvic (n=36) and pelvic + lumbar lymphadenectomy (n=31), lymph node metastases were detected in 4 (11.1 %) and 6 (19.4 %) patients, respectively. In the high-risk group (n=50) with similar surgeries, metastatic lymph nodes were identified in 2 (10.5 %, n=19) and 6 (26.1 %, n=23) patients, respectively. At Kaluga Regional Oncology Center, 231 patients underwent hysterectomy with sentinel lymph node biopsy. The low-risk group, the medium-risk group, and the high-risk group showed lymph node metastases in 7 (5.47 %), 6 (10.2 %), and 6 (13.6 %) patients, respectively.

Conclusion. In stage I endometrial cancer patients with a low risk of lymph node metastasis, hysterectomy with sentinel lymph node biopsy is recommended. For medium-and high-risk groups, hysterectomy with systemic lymphadenectomy is recommended. If it is not possible to remove the pelvic and lumbar lymph nodes, their biopsy with ICG mapping and microstaging can be recommended. A combination of systemic lymphadenectomy with sentinel lymph node biopsy is a promising technique that could hypothetically demonstrate better results in terms of disease staging.
The role of communication in sustainable development of the territory (case of the Baikal natural territory)
Authors: Panova E. V.
Published: January 2024

Modern society is experiencing a transformation of the existing management system. The industrial growth model has been replaced by the concept of sustainable development. Its strategic goal is to achieve a balance between economics, environmental sustainability and social responsibility. Thus, the very nature of sustainability involves communication and interaction. The objective of this study is to analyze the sustainable development of the Baikal natural territory and the role of communications in this process. In the work, the author turned to Russian and foreign research on issues of sustainable development and its communicative component. In the practical part, the author assesses social, economic and environmental sustainability, proposes types of sustainable development strategies based on the communication component. The results of the analysis show the lack of sustainability of the development of the Baikal natural territory, which contributes to the emergence of heated discussions regarding the future. Its participants are various subjects. Their goals, level of knowledge and power resources are different, which affects their readiness for structural changes and does not exclude a conflict of values between the participants. An assessment of the measures taken allows to identify several types of sustainable development management strategies: regulatory, programmatic, research, coordination, reflexive, communicative and managerial. The author believes that, with account to its high ambivalence, strategic environmental communications contribute to achieving sustainability.
Characteristics of Mediaspace: influence on the polarization of public opinion
Authors: Kirillina N. V. , Fabrichnykh M. A.
Published: January 2024

The development of the new media and the transfer of mass and interpersonal communications into the digital space, on the one hand, opens up the opportunity for interaction and obtaining information regardless of geographical, sociocultural and time factors, on the other hand, it creates new patterns of interaction with and within the media, as well as social interaction in in general. By virtue of the ability to quickly access a large amount of information, a media user develops a sense of freedom to choose its source. At the same time, despite the seemingly openness of the media space and unlimited access to information, its perception by different groups of users is not heterogeneous. Observation of very emotional discussions on the network on some issues on the agenda allows us to search for a relationship between the nature of the dissemination of information in media communities and the growing polarization of opinions on media content. These assumption actualizes the need to identify characteristics of the media space that may (1) influence the perception of information by users and (2) increasing the resonance between different groups of media users and subscribers.
Training of media specialists in the field of social communication
Authors: Avakova E. B. , Kuznetsov A. A.
Published: January 2024

The article is devoted to the problems of training of media specialists in the context of improving the system of higher education in Russia. Based on the analysis of theoretical and empirical materials, the authors substantiate the need to transform the media education system in Russia in order to train professional communicators of a new formation. Based on the results of their own sociological research and the results obtained by other researchers, the authors confirm the presence of certain difficulties in educational media programs. E.g., students show average level of media literacy, unconscious behavior as consumers of information, and difficulties with information verification. Failure to overcome all that difficulties may lead to the fact that the ranks of future media specialists in the field of social communication will be replenished with personnel who does not correspond to this activity emotionally and professionally. The activities of such non-professionals significantly affects the level of public trust in any information in the media The logic of the research allows the authors to come to conclusions that in Russia there is a clear public demand for media specialists of high professional level, truthfully and responsibly forming the modern public agenda.
The specificity of conflict triggers in fine literature discourse (based on Telluria novel by Vladimir Sorokin)
Authors: Polovinkina O. S.
Published: January 2024

Russian culture has always been literary-centric. The appeal to the literary text as a way of understanding oneself and social reality remains up till now a significant part of the educational process. Social conflicts are reflected in Russian prose. The paper is devoted to the study of the concept of conflict and the specifics of its implementation in the discourse of literature using based on the novel by Vladimir Sorokin “Telluria”. We believe that the emergence of a conflict occurs at the point when one of the subjects deprives the other of his subjectivity and begins to impose his point of view. A distinctive feature of conflicts of this kind of discourse is the in communication – author’s and reader’s. Besides due to achronicity in relation to real time literary texts are more durable and resistant to changing agendas, and are also able to influence reality even after time. Few modern Russian authors describe modern realities. Sorokin is one of the most famous and influential writers of modern Russia, who is known far beyond its borders. Some of the fantastic nature of Sorokin’s plots at a long distance turns out to be quite accurate in diagnosing modernity. The article examines lexical units that can become absolute conflict triggers. All of them relate to the subject, its attribute or activity. In a literary text, neutral words can also generate conflict that is influenced by the context. The study of conflicts in different discourses will allow us to identify common conflict-prone vocabulary characteristic for the Russian cultural field.
GIS Approach for Spatial Data Visualization of Food Service Operator in Jakarta, Indonesia
Authors: Steven Raymond , Nofriani Allya Bertha , Malik Samuel , Widaningrum Dyah Lestari
Published: January 2024

The purpose of this study is to help the company to improve customer satisfaction about Red Bean restaurant locations. To improve the customer satisfaction in this study used Geographic Information System based on Thiessen polygon, buffer zone, and distribution facility analysis. The conclusions of this research are the company needs to improve restaurant location using Geographic Information System method.
Research on modulation recognition method of electromagnetic signal based on wavelet transform convolutional neural network
Authors: Gao Wanfang
Published: January 2024

The method of electromagnetic signal modulation recognition based on wavelet transform convolutional neural network is studied to improve the effect of electromagnetic signal modulation recognition. By analyzing the electromagnetic signal modulation model, the original electromagnetic signal is preprocessed by wavelet transform to remove the noise of the original electromagnetic signal. The processed electromagnetic signal is used as the input of convolutional neural network, and the electromagnetic signal feature vector is extracted through the convolution layer of convolutional neural network. By using full connection operation, the advanced feature vector of electromagnetic signal is integrated, and the electromagnetic signal is classified by softmax function, and the electromagnetic signal modulation recognition result is output, thus realizing the electromagnetic signal modulation recognition. The experimental results show that when the number of layers of wavelet decomposition is 7 and the wavelet function is Db9, the wavelet transform has the best denoising effect on electromagnetic signal data. At the same time, the network training efficiency of this method is high, and the accuracy of electromagnetic signal modulation recognition is as high as 97.2 %, which improves the effect of electromagnetic signal modulation recognition and is suitable for various types of electromagnetic signal modulation recognition.
General Self-Efficacy Associations with Personality and Motivation: Psychometric Properties and Measurement Invariance of the Polish New General Self-Efficacy Scale
Authors: Baran Lidia , Janowski Maciej
Published: January 2024

This study aimed to determine the validity and reliability of the Polish version of the New General Self-Efficacy Scale (NGSE). In four different samples (N = 1,837), adult respondents completed the Polish version of NGSE (NGSEpl) in combination with questionnaires assessing personality, motivation, and behavioral tendencies. Confirmatory factor analysis demonstrated a good fit for the one-factor structure. Cronbach's alpha was above .87 in all samples, and the stability of the scale was .68. Measurement invariance of NGSEpl calculated for different age groups confirmed that the scale measures the same construct in both samples. NGSEpl scores were positively related to the frequency of active coping strategies, mastery-goal orientation, and Big Five model traits and negatively to passive coping strategies. Results supported the reliability, stability, and validity of the NGSEpl.
Withdrawn: Probucol will Become a New Model for Treating Cerebral Infarction with a High Risk of Hemorrhage
Authors: Lang Liguo , Zhang Jianying , Gao Huanmin
Published: January 2024

This article has been withdrawn due to a plagiarism complaint regarding significant overlap with a previously published article
titled "Probucol will Become a New Model for Treating Cerebral Infarction with a High Risk of Hemorrhage: A Narrative Review," which appeared in Brain Circulation in 2023, Volume 9, Issue 4, DOI: 10.4103/bc.bc_44_23.
The authors were informed of the plagiarism claim and were given the opportunity to provide a response or justification. However, no reply was received from the authors.
As a result, the publisher has withdrawn this article in accordance with ethical standards and best practices in scholarly publishing.
Bentham Science apologizes to the readers of the journal for any inconvenience this may cause.
The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php
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ADGRL4 Promotes Cell Growth, Aggressiveness, EMT, and Angiogenesis in Neuroblastoma via Activation of ERK/STAT3 Pathway
Authors: Geng Geng , Zhang Lei , Yu Ying , Guo Xingqing , Li Qinghao , Ming Ming
Published: January 2024

Background:

Neuroblastoma (NB) is one of the most common pediatric
solid tumors. Emerging evidence has indicated that ADGRL4 can act as a master
regulator of tumor progression. In addition, it is well documented that the ERK/STAT3
signaling pathway can promote the proliferation, EMT, angiogenesis, and metastasis in
tumors. The current study was formulated to elucidate the exact role of ADGRL4 in the
malignant behaviors of NB cells and to investigate the intrinsic mechanism.

Methods:

In this work, expression differences of ADGRL4 in human NB cell lines and
HUVECs were assessed via RT-qPCR and western blot analysis. For functional
experiments, sh-ADGRL4 was transfected into SK-N-SH cells to generate ADGRL4
knockdown stable cell line. Moreover, ADGRL4 knockdown stable SK-N-SH cells were
treated with LM22B-10 (an ERK activator) for rescue experiments. CCK-8, colony
formation, would healing, and transwell assays determined NB cell growth, migration,
and invasion. Meanwhile, proliferation-, metastasis- and EMT- associated proteins
were also detected. Additionally, a tube formation assay was employed to evaluate in
vitro angiogenesis. VM-cadherin, the marker of angiogenesis, was assessed using
immunofluorescence staining.

Results:

Data showed notably upregulated ADGRL4 in NB cells, especially in SK-NSH
cells. ADGRL4 knockdown inhibited NB cell growth, migration, invasion, EMT, and
in vitro angiogenesis. ADGRL4 knockdown inactivated ERK/STAT3 signaling pathway.
Activation of the ERK/STAT3 signaling pathway partially rescued the tumor
suppression effects of ADGRL4 knockdown on NB cells.

Conclusion:

To conclude, the downregulation of ADGRL4 may inhibit cell growth,
aggressiveness, EMT, and angiogenesis in NB by inactivating the ERK/STAT3
signaling pathway.
Overcoming Skin Barrier with Transfersomes: Opportunities, Challenges, and Applications
Authors: Dixena Bhupendra , Madhariya Rashmi , Panday Anupama , Ram Alpana , Jain Akhlesh K.
Published: January 2024

Background:

Transdermal drug delivery systems (TDDS) offer several advantages over
traditional methods such as injections and oral administration. These advantages include preventing
first-pass metabolism, providing consistent and sustained activity, reducing side effects, enabling the
use of short half-life drugs, improving physiological response, and enhancing patient convenience.
However, the permeability of skin poses a challenge for TDDS, as it is impermeable to large molecules
and hydrophilic drugs but permeable to small molecules and lipophilic drug. To overcome this
barrier, researchers have investigated vesicular systems, such as transfersomes, liposomes, niosomes,
and ethosomes. Among these vesicular systems, transfersomes are particularly promising for noninvasive
drug administration due to their deformability and flexible membrane. They have been extensively
studied for delivering anticancer drugs, insulin, corticosteroids, herbal medicines, and
NSAIDs through the skin. Transfersomes have demonstrated efficacy in treating skin cancer, improving
insulin delivery, enhancing site-specific corticosteroid delivery, and increasing the permeation
and therapeutic effects of herbal medicines. They have also been effective in delivering pain relief
with minimal side effects using NSAIDs and opioids. Transfersomes have been used for transdermal
immunization and targeted drug delivery, offering site-specific release and minimizing adverse effects.
Overall, transfersomes are a promising approach for transdermal drug delivery in various therapeutic
applications.

Objectives:

The aim of the present review is to discuss the various advantages and limitations of
transfersomes and their mechanism to penetration across the skin, as well as their application for the
delivery of various drugs like anticancer, antidiabetic, NSAIDs, herbal drugs, and transdermal immunization.

Methods:

Data we searched from PubMed, Google Scholar, and ScienceDirect.

Results:

In this review, we have explored the various methods of preparation of transfersomes and
their application for the delivery of various drugs like anticancer, antidiabetic, NSAIDs, herbal drugs,
and transdermal immunization.

Conclusion:

In comparison to other vesicular systems, transfersomes are more flexible, have greater
skin penetration capability, can transport systemic medicines, and are more stable. Transfersomes are
capable of delivering both hydrophilic and hydrophobic drugs, making them suitable for transdermal
drug delivery. The developed transfersomal gel could be used to improve medicine delivery through
the skin.
The Application of Artificial Intelligence in Thyroid Nodules: A Systematic
Review Based on Bibliometric Analysis
Authors: Peng Yun , Wang Tong-Tong , Wang Jing-Zhi , Wang Heng , Fan Ruo-Yun , Gong Liang-Geng , Li Wu-Gen
Published: January 2024

Background:

Thyroid nodules are common lesions in benign and malignant thyroid
diseases. More and more studies have been conducted on the feasibility of artificial intelligence
(AI) in the detection, diagnosis, and evaluation of thyroid nodules. The aim of this study was to
use bibliometric methods to analyze and predict the hot spots and frontiers of AI in thyroid nodules.

Methods::

Articles on the application of artificial intelligence in thyroid nodules were retrieved
from the Web of Science core collection database. A website (https://bibliometric.com/),
VOSviewer and CiteSpace software were used for bibliometric analyses. The collaboration
maps of countries and institutions were analyzed. The cluster and timeline view based on cocitation
references and keywords citation bursts visualization map were generated.

Results:

The study included 601 papers about AI in thyroid nodules. China contributed to more
than half (52.41%) of these publications. The cluster view and timeline view of co-citation references
were assembled into 9 clusters, “AI”, “deep learning”, “papillary thyroid carcinoma”,
“radiomics”, “ultrasound image”, “biomarkers”, “medical image segmentation”, “central lymph
node metastasis (CLNM)”, and “self-organizing auto-encoder”. The “AI”, “radiomics”, “medical
image segmentation”, “deep learning”, and “CLNM”, emerging in the last 10 years and
continuing until recent years.

Conclusion:

An increasing number of scholars were devoted to this field. The potential future
research hotspots include risk factor assessment and CLNM prediction of thyroid carcinoma
based on radiomics and deep learning, automatic segmentation based on medical images (especially
ultrasound images).
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment
Authors: Zaretsky Tamar Glatman , Jagodnik Kathleen M. , Barsic Robert , Antonio Josimar Hernandez , Bonanno Philip A. , MacLeod Carolyn , Pierce Charlotte , Carney Hunter , Morrison Morgan T. , Saylor Charles , Danias George , Lepow Lauren , Yehuda Rachel
Published: January 2024

Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following
exposure to a traumatic experience. An estimated 12 million U.S. adults are presently affected by this
disorder. Current treatments include psychological therapies (e.g., exposure-based interventions) and
pharmacological treatments (e.g., selective serotonin reuptake inhibitors (SSRIs)). However, a significant
proportion of patients receiving standard-of-care therapies for PTSD remain symptomatic, and
new approaches for this and other trauma-related mental health conditions are greatly needed. Psychedelic
compounds that alter cognition, perception, and mood are currently being examined for their efficacy
in treating PTSD despite their current status as Drug Enforcement Administration (DEA)-
scheduled substances. Initial clinical trials have demonstrated the potential value of psychedelicassisted
therapy to treat PTSD and other psychiatric disorders. In this comprehensive review, we
summarize the state of the science of PTSD clinical care, including current treatments and their shortcomings.
We review clinical studies of psychedelic interventions to treat PTSD, trauma-related disorders,
and common comorbidities. The classic psychedelics psilocybin, lysergic acid diethylamide
(LSD), and N,N-dimethyltryptamine (DMT) and DMT-containing ayahuasca, as well as the entactogen
3,4-methylenedioxymethamphetamine (MDMA) and the dissociative anesthetic ketamine, are
reviewed. For each drug, we present the history of use, psychological and somatic effects, pharmacology,
and safety profile. The rationale and proposed mechanisms for use in treating PTSD and traumarelated
disorders are discussed. This review concludes with an in-depth consideration of future directions
for the psychiatric applications of psychedelics to maximize therapeutic benefit and minimize
risk in individuals and communities impacted by trauma-related conditions.
Surrealismo Português e Surrealismo Internacional a partir da correspondência de Mário Cesariny com Sérgio Lima, Laurens Vancrevel e Frida Vancrevel
Authors: Sousa Rui
Published: January 2024

From the end of the 1960s onwards, Mário Cesariny established a prolific dialogue with the international surrealist movement, with repercussions on the way in which the Portuguese Surrealism came to be considered. In this paper, I propose a perspective on Cesariny's critical intervention in a moment of transition in the panorama of the international surrealist movement, represented, on the one hand, by a certain decentralization in relation to the Parisian paradigm and, on the other hand, by the pluralization of surrealist groups. Cesariny's correspondence with the Brazilian Sergio Lima and with the Dutch Laurens and Frida Vancrevel are taken as a starting point, articulated with his critical and anthological activity. These epistolography contains the fundamental aspects of Cesariny's criticism of the limitations of the narrative disseminated internationally regarding the Portuguese case and its integration in the context of a critical review of Surrealism.
Por um conceito de revolução surrealista
Authors: Lamas Gabriel Bustilho
Published: January 2024

This article seeks, through texts from the magazines La Révolution surréaliste (1924-1929) and Le Surréalisme au service de la révolution (1930-1933), to think about what would be the “surrealist revolution” that Breton and company sought in the early years of the movement. This will be done by going through the ideas that the surrealists manifested about the revolution (both their own and that of others, more specifically, the communist revolution). In addition, it will also be necessary to reinsert, within surrealism, one of its most important dissidents, Antonin Artaud, who was expelled precisely because of the debate about what the “surrealist revolution” would be.
Edamame caspian sea soygurt as plant-based yogurt alternatives
Authors: Kusnadi Joni , Septi Nur Diana , Fibrianto Kiki
Published: January 2024

Caspian sea soygurt is made by fermenting edamame milk with Lactococcus lactis ssp. cremoris and Acetobacter orientalis as microbial cultures. To produce good soygurt, edamame milk fermentation requires ideal conditions, such as an optimum carbon source and starter concentration. This study aimed to determine the effect of the proportion of sucrose:skim and concentration of starter on the physical, chemical, microbiological, and sensory characteristics of Caspian sea soygurt. This study used a randomized block design with 2 factors: sucrose:skim proportion (2.5:7.5, 5:5 7.5:2.5) and starter concentration (8, 10, 12% of pasteurized edamame milk) repeated three times. Data were analyzed using ANOVA and continued with the Tukey test. These results was used to select the best treatment using the Zeleny Multiple Attribute Method. The best Caspian soygurt treatment was found in the proportion of sucrose:skim 5:5 (% w/v of pasteurized edamame milk) and starter concentration 12 (% v/v of pasteurized edamame milk), which produced a color (L*) 78.98, (a*) -2.86 ( b*) 23.79, viscosity 516.67 cP, protein 3.38%, antioxidant activity 43.12%, pH 4.35, total lactic acid bacteria 9.85 log CFU/mL with a preference level of 3.45 and an acceptance level of 3.55 for the greenness, a preference level of 3.79 and an acceptance level of 3.80 for the brightness, a preference level of 3.15 and an acceptance level 3.21 on the sour aroma, preference level of 3.04 and acceptance level of 3.11for the beany aroma, preference level of 3.04 and acceptance level of 3.18 for the beany flavor, preference level of 3.02 and acceptance level of 3.19 for the sour taste, preference level of 2.98 and acceptance level of 3.09 for sweet taste, preference level of 3.49 and acceptance level of 3.60 for the viscosity.
HUBUNGAN PERSEPSI IBU TENTANG PENTINGNYA IMUNISASI ANAK DIBAWAH USIA 2 TAHUN DENGAN TINGKAT KEPATUHAN JADWAL IMUNISASI DI PUSKESMAS SINGOSARI KABUPATEN MALANG
Authors:   Bachelor of Midwifery Program Universitas Brawijaya, Putri Acness Yuliana , Monica Laurentia Ima ,   Brawijaya University, Fransiska Ratna Diana ,   Brawijaya University
Published: January 2024

Background : Immunization is the prevention of dangerous diseases and as one of the government's efforts to achieve the Sustainable Development Goals (SDGs), namely preventing deaths in children. In 2020 at the beginning of March, the COVID-19 pandemic has spread into Indonesia. Activity restrictions make some mothers have an incorrect perception and have an impact on reducing immunization visits that should be carried out as schedule. Aims : Knowing whether there is a relationship between the mother's perception of the importance of immunization and compliance with the immunization schedule at the Public Health Center. Methods : This research uses an analytical method with a Cross Sectional approach. The sample was 110 mothers who had children under the age of 2 years. The data was collected through google form and analysis using chi square test. Result and Discussion : The results of the chi square test obtained significant results (p = 0.000) with p <0.05 weighing H0 was rejected and H1 was accepted. Conclusion : There is a relationship mothers perceptions of the importance of immunization of children under the age of 2 years to the level of compliance with the immunization schedule at the Singosari PHC, Malang Regency.