bluuebunny/crossref_metadata_2025 huggingface dataset:
Testimony on a successful lab protocol to disrupt Chlorella vulgaris microalga cell wall
Authors: Lopes Paula A. , Coelho Diogo , Prates José A. M.
Published: May 2022

Over the last decades, microalgae have gained popularity due to demand for novel environmental green solutions and development of innovative mass-production sources for multiple processes, including animal feed and human diet, turning microalgae into an exquisite candidate for several ecofriendly technologies. Notwithstanding, there is a catch. Most species of microalgae, as the case of common Chlorella vulgaris (C. vulgaris) display a recalcitrant cell wall, characterized by a complex matrix of polysaccharides and glycoproteins, which constitutes a major barrier for monogastric species digestibility and extraction of inner valuable nutritional compounds. To overcome this limitation, the development of feed enzymes, in particular Carbohydrate-Active enZymes (CAZymes) with capacity to disrupt C. vulgaris cell wall may contribute to improve the bioavailability of these microalgae compounds in monogastric diets, namely at high levels of incorporation. In order to disclosure novel combination of feed enzymes to disrupt C. vulgaris cell wall, a lab protocol was implemented by our research team containing the following key steps: after microalgae cultivation and having available a repertoire of two hundred pre-selected CAZymes produced by high-throughput technology, the step 1 is the individual screening of the most functional enzymes on disrupting C. vulgaris cell wall (versus a control, defined as the microalgae suspension incubated with PBS) and the determination of reducing sugars released by the 3,5-dinitrosalicylic acid (DNSA) method; step 2 concerns on finding the best CAZymes cocktail, testing the synergistic effect of enzymes, to disrupt C. vulgaris cell wall (in parallel with running the control) along with characterization of each enzyme thermostability and resistance to proteolytic attack, to which feed enzymes are subjected in the animal gastrointestinal tract; step 3 is the assessment of C. vulgaris cell wall degradation degree by measuring the amount of reducing sugars released by the DNSA method, fatty acid analysis by gas chromatography (GC) with flame ionization detector (FID), oligosaccharides quantification by high performance liquid chromatography (HPLC) equipped with an electrochemical detector (ECD), protein content by the Kjeldahl method, and various pigments (chlorophylls a and b, and total carotenoids) in the supernatant. In the correspondent residue, we also assessed cellular counting using a Neubauer chamber by direct observation on a bright-field microscope and fluorescence intensity, after staining with Calcofluor White for both control and CAZymes cocktail treatments, on a fluorescence microscope. Beyond animal feed industry with impact on human nutrition, our lab protocol may increase the yield in obtaining valued constituents from C. vulgaris microalga for other biotechnological industries.
Transcriptome analysis reveals high tumor heterogeneity with respect to re-activation of stemness and proliferation programs
Authors: Baranovsky Artem , Ivanov Timofei , Granovskaya Marina , Papatsenko Dmitri , Pervouchine Dmitri D.
Published: May 2022

Significant alterations in signaling pathways and transcriptional regulatory programs together represent major hallmarks of many cancers. These, among all, include the reactivation of stemness, which is registered by the expression of pathways that are active in the embryonic stem cells (ESCs). Here, we assembled gene sets that reflect the stemness and proliferation signatures and used them to analyze a large panel of RNA-seq data from The Cancer Genome Atlas (TCGA) Consortium in order to specifically assess the expression of stemness-related and proliferation-related genes across a collection of different tumor types. We introduced a metric that captures the collective similarity of the expression profile of a tumor to that of ESCs, which showed that stemness and proliferation signatures vary greatly between different tumor types. We also observed a high degree of intertumoral heterogeneity in the expression of stemness- and proliferation-related genes, which was associated with increased hazard ratios in a fraction of tumors and mirrored by high intratumoral heterogeneity and a remarkable stemness capacity in metastatic lesions across cancer cells in single cell RNA-seq datasets. Taken together, these results indicate that the expression of stemness signatures is highly heterogeneous and cannot be used as a universal determinant of cancer. This calls into question the universal validity of diagnostic tests that are based on stem cell markers.
Exploring patient experiences of participating in a real and sham dry cupping intervention for nonspecific low back pain: A qualitative study
Authors: Almeida Silva Hugo Jário , Avila Mariana Arias , Castro Kamilla Maria Sousa , Pinheiro Yago Tavares , Lins Caio Alano Almeida , Medeiros Barbosa Germanna , de Souza Marcelo Cardoso
Published: May 2022

Background

The current quality of evidence supporting dry cupping for individuals with chronic low back pain (CLBP) is low and suggests that nonspecific factors impact experiences reported by patients. Therefore, this study assessed the impacts of social and professional support on the experience of individuals with CLBP treated with dry cupping or sham.

Method

This is an observational study with qualitative approach. Twenty-four individuals with CLBP who received dry cupping or sham in a previous clinical trial were invited. Data was collected using a semi-structured interview conducted by a trained researcher. Content analysis was used to analyze experiences, systematic procedures, and description of the content of messages. The dimensions of “pain”, “general perceptions”, and “perceived social and professional support” guided the analysis.

Results

Answers of both groups converged on similar perceptions, especially regarding pain. Physical condition was the most fragile aspect. We also observed an influence of perceived social and professional support on painful symptoms. Thus, the experience of individuals with CLBP treated with dry cupping or sham indicated that factors related to social and professional support impacted results.

Conclusions

We observed that individuals with CLBP reported similar perceptions of the effects of dry cupping or sham treatment, indicating that contextual factors may influence the perception of these individuals regarding the treatment received.
Tetanus seroprotection among children in the Democratic Republic of the Congo, 2013–2014
Authors: Cheng Alvan , Ghanem-Uzqueda Angie , Hoff Nicole A. , Ashbaugh Hayley , Doshi Reena H. , Mukadi Patrick , Budd Roger , Higgins Stephen G. , Randall Christina , Gerber Sue , Kabamba Michel , Ngoie Mwamba Guilluame , Okitolonda-Wemakoy Emile , Muyembe-Tanfum Jean Jacques , Rimoin Anne W.
Published: May 2022

Background

Tetanus is a potentially fatal disease that is preventable through vaccination. While the Democratic Republic of the Congo (DRC) has continued to improve implementing routine vaccination activities throughout the country, they have struggled to maintain high childhood vaccine coverage. This study aims to examine the seroprevalence of tetanus in children 6 to 59 months to identify areas for intervention and improvement of vaccination coverage.

Methods

In collaboration with the 2013–2014 Demographic and Health Survey, we assessed the seroprevalence of tetanus antibodies among children in the DRC. Dried blood spot samples collected from children 6–59 months of age were processed using a prototype DYNEX Multiplier® chemiluminescent automated immunoassay instrument with a multiplex measles, mumps, rubella, varicella and tetanus assay. Multivariable logistic regression was used to determine factors associated with tetanus vaccination and seroprotection.

Results

Overall, 36.1% of children 6–59 months of age reported receiving at least 1 dose of tetanus vaccine while 28.7% reported receiving 3 doses; tetanus seroprotection was 40%. Increasing age in children was associated with decreased tetanus seroprotection, but increased number tetanus vaccinations received. Factors related to increased tetanus seroprotection included number of children in the household, wealth index of the family, urban residence compared to rural, level of maternal education, and province and geography.

Conclusions

Our findings in this nationally representative sample indicate that serology biomarkers may help identify children who are not fully immunized to tetanus more accurately than reported vaccination. While children may be captured for routine immunization activities, as children age, decreasing seroprevalence may indicate additional need to bolster routine vaccination activities and documentation of vaccination in school aged children. Additionally, the study highlights gaps in rural residential areas and vaccination coverage based on maternal education, indicating that policies targeting maternal education and awareness could improve the coverage and seroprevalence of tetanus antibodies in the DRC.
15-PGDH regulates hematopoietic and gastrointestinal fitness during aging
Authors: Ho Won Jin , Smith Julianne N. P. , Park Young Soo , Hadiono Matthew , Christo Kelsey , Jogasuria Alvin , Zhang Yongyou , Broncano Alyssia V. , Kasturi Lakshmi , Dawson Dawn M. , Gerson Stanton L. , Markowitz Sanford D. , Desai Amar B.
Published: May 2022

Emerging evidence implicates the eicosanoid molecule prostaglandin E2 (PGE2) in conferring a regenerative phenotype to multiple organ systems following tissue injury. As aging is in part characterized by loss of tissue stem cells’ regenerative capacity, we tested the hypothesis that the prostaglandin-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) contributes to the diminished organ fitness of aged mice. Here we demonstrate that genetic loss of 15-PGDH (Hpgd) confers a protective effect on aging of murine hematopoietic and gastrointestinal (GI) tissues. Aged mice lacking 15-PGDH display increased hematopoietic output as assessed by peripheral blood cell counts, bone marrow and splenic stem cell compartments, and accelerated post-transplantation recovery compared to their WT counterparts. Loss of Hpgd expression also resulted in enhanced GI fitness and reduced local inflammation in response to colitis. Together these results suggest that 15-PGDH negatively regulates aged tissue regeneration, and that 15-PGDH inhibition may be a viable therapeutic strategy to ameliorate age-associated loss of organ fitness.
Predictors of Gastrointestinal Transit Times in Colon Capsule Endoscopy
Authors: Moen Sarah , Vuik Fanny E.R. , Voortman Trudy , Kuipers Ernst J. , Spaander Manon C.W.
Published: May 2022

Background:

Optimizing the accuracy of colon capsule endoscopy (CCE) requires high completion rates. To prevent incomplete CCE, we aimed to identify predictors associated with slow CCE transit times.

Methods:

In this population-based study, participants received CCE with split-dose PEG bowel preparation and booster regimen (0.5L oral sulfate solution and 10mg metoclopramide if capsule remained in stomach > 1 hour). The following predictors were assessed: age, gender, body mass index (BMI), smoking, coffee and fiber intake, diet quality, physical activity, dyspeptic complaints, stool pattern, history of abdominal surgery, medication use, and CCE findings. Multivariable logistic and linear regressions with backward elimination were performed.

Results:

We analyzed 451 CCE procedures with a completion rate of 51.9%. Completion rate was higher among older participants (odds ration [OR] 1.54, 95% confidence interval [CI] 1.04-2.28, P=0.03) and participants with changed stool pattern (OR 2.27, 95% CI 1.20-4.30, P=0.01). Participants with history of abdominal surgery had a lower completion rate (OR 0.54, 95% CI 0.36-0.80, P=0.003). Participants with higher BMI had faster stomach, small bowel and total transit times (β=-0.10, P=0.01; β=-0.14, P=0.001; β=-0.12, P=0.01). A faster small bowel transit was found in participants with changed stool pattern (β=-0.08, P=0.049) and use of metoclopramide (β=-0.14, P=0.001). Participants with high fiber intake had a slower colonic transit (β=0.11, P=0.03).

Discussion:

Younger age, unchanged stool pattern, history of abdominal surgery, low BMI, and high fiber intake resulted in slower CCE transit times and lower completion rates. In future practice, these factors can be considered to adjust preparation protocols.
La atención a los padres con hijos con necesidades educativas especiales (NEE)
Authors: Pernas Pico Claudia María
Published: May 2022

Los padres que tienen hijos con necesidades educativas especiales (NEE) necesitan al igual que sus hijos intervenciones logopédicas por parte del profesorado especialista. De nada sirve atiborrar a un hijo de sesiones de logopedia si los padres en casa no saben como tratar ni como estimular a su hijo. Si los aprendizajes no se generalizan del colegio a casa y de casa al colegio no existe la educación, y menos aún al hablar de logopedia y de niños discapacitados o con graves trastornos de conducta. Se pretende en este artículo dar un abanico de posibilidades de cómo se puede intervenir con los padres desde las escuelas: con formación, con actividades para ellos y para sus hijos, con libretas viajeras, con pequeñas pautas, con largas horas de reuniones,… Siempre desde la empatía y la profesionalidad que debe transmitir el maestro.
Orígenes de la formación laboral en el Caribe colombiano, condiciones y concepciones. El caso de Montería
Authors: Montes Miranda Alexander Javier , Manning Bula Liliana
Published: May 2022

El presente artículo se centra en el Informe acerca de la identificación de los factores que afectan la calidad en las instituciones de educación para el trabajo en la ciudad de montería, a partIr de las concepcIones que tiene la comunidad monteriana sobre ellas. Dicho estudio se hizo mediante un diseño metodológico cualitativo, con enfoque narrativo y descriptivo, teniendo en cuenta el análisis del discurso de las personas que participaron en la muestra del estudio. Para ello se seleccionó una población diversa. Dentro de los factores identificados que afectan la calidad de la educación para el trabajo y el desarrollo humano de la ciudad de Montería aparecen las inadecuadas condiciones infraestructurales, además de la falta de recursos necesarios para la formación laboral, aspectos que han generado una percepción negativa en la comunidad de Montería, donde se le considera de poco valor y credibilidad, con un evidente interés lucrativo.
Reflexiones en torno al acompañamiento en los procesos de mejora de la práctica educativa en la educación preescolar
Authors: Jaramillo Leonor de Lourdes , Osorio Margarita , Iriarte Fernando
Published: May 2022

El presente trabajo recoge las reflexiones surgidas de un proceso de acompañamiento auspiciado por un grupo de Fundaciones de empresas privadas a un grupo de instituciones oficiales de Barranquilla y Ciénaga (Colombia) con el fin de mejorar la práctica pedagógica en los niveles de preescolar. Se analizan particularidades, elementos comunes, fortalezas, debilidades, logros e inconvenientes en los diferentes contextos en que se llevó a cabo la experiencia. La finalidad de este escrito es abrir un diálogo con otras experiencias similares y develar algunas circunstancias que ayuden a aquellos que están iniciando prácticas relacionadas y que quisieran tener referencias para tener en cuenta en el diseño de sus propuestas de intervención.
Factores académicos y personales asociados al rendimiento académico de los estudiantes del Programa de Administración de Empresas de la Universidad de Sucre
Authors: Mercado Covo Tatiana Margarita , Niño Sotomayor Candelaria Gloria
Published: May 2022

El rendimiento académico es un indicador que permite conocer los resultados del desempeño y aprendizaje en los estudiantes de una institución universitaria; así pues, el objetivo de esta investigación demostró la relación entre los factores personales y académicos con el rendimiento académico de los estudiantes en la Universidad de Sucre. Las variables estudiadas se fundamentaron en los trabajos de Garbanzo, (2007), Montero y Villalobos, (2001), Beguet, Cortada, Castro, y Renault, (2001), Talavera, Noreña, Melgar et al. (2006), Sotelo y Vales (2007), entre otros. La investigación fue de tipo cuantitativa y del orden correlacional. Los resultados determinaron que los estudiantes con resultados académicos deficientes están siendo afectados por algunos procesos de enseñanza utilizados por los docentes al desarrollar las actividades académicas en el aula y fuera de ella; también se determinó que la motivación intrínseca favorece su rendimiento.
Una propuesta para desarrollar Competencias en Información para estudiantes de Secundaria Básica. Modelo DELFÍN
Authors: González Rivero María del Carmen
Published: May 2022

Se ha desarrollado el modelo para la alfabetización informacional, formación vocacional y orientación profesional de los estudiantes de la enseñanza media básica hacia la especialidad de Bibliotecología. El objetivo estuvo en diseñar una estrategia que indica el progreso del estudiante a través de cada módulo que abarcan desde habilidades básicas, intermedias y avanzadas; en la cual se declaran las tareas docentes, la responsabilidad en la ejecución de la tarea, la evaluación a través de los objetivos del método y los resultados de aprendizaje en correspondencia con las aptitudes del Modelo de DELFIN (Desarrollo de Estudiantes Lectores, Fortalecidos en Información).
Does a cervical pessary reduce the rate of preterm birth in women with a short cervix?
Authors: Kumagai Kyoko , Murotsuki Jun , Dohi Satoshi , Nishikawa Naomi , Kimura Naomi , Nomiyama Makoto , Osaga Satoshi , Hashimoto Hiroya , Nakai Akihito , Sugiura-Ogasawara Mayumi , Ozaki Yasuhiko
Published: May 2022

Objectives

To evaluate neonatal outcomes after the use of a cervical pessary in Japanese women with short cervical length (CL) less than 25 mm.

Methods

This multicenter study involved women with singleton pregnancies between 20 and 29+6 gestational weeks and a CL of less than 25 mm. The primary outcome was preterm birth (PTB) before 34 weeks of gestation. This study was registered in the Japan Registry of Clinical Trials (JRCT: jRCTs042180102).

Results

Two hundred pregnant women were enrolled; 114 in the pessary group and 86 in the expectant management group as controls. In the pessary group, all 114 neonates were investigated for perinatal outcomes, and 112 pregnant women were investigated for primary, and secondary outcomes. In the control group, 86 pregnant women were investigated for primary and secondary outcomes and 86 neonates were investigated for neonatal outcomes. There were no significant differences in PTB in ≤34, ≤37, and ≤28 weeks of gestation or in preterm rupture of membranes (PROM) ≤34 weeks between the groups. The gestational weeks at birth and birth weight were significantly higher in the pessary group. Regression analysis demonstrated that the CL decreased without a pessary, whereas the shortening rate was suppressed during the intervention. No significant differences were observed in adverse neonatal outcomes, chorioamnionitis, or preterm PROM.

Conclusions

The cervical pessary effectively reduced CL shortening during pregnancy resulting in an average increased gestational age, however, did not reduced the rates of preterm birth.
Evaluating the correlation between amniotic fluid volume and estimated fetal weight in healthy pregnant women
Authors: Souza Sara C.S. , Kim Katherine , Dingwall-Harvey Alysha L.J. , Fakhraei Romina , Liao Yan , Gaudet Laura M.
Published: May 2022

Objectives

The establishment of cut-offs for normal amniotic fluid volume (AFV) is valuable to predict perinatal outcomes. However, the most common methods to measure AFV are not accurate enough. It is important to understand factors that may be able to increase the accuracy of the calculation of AFV cut-off values. The objective of this study was to verify the correlation between AFV and estimated fetal weight (EFW).

Methods

Records from almost 7,000 patients between 2012 and 2017 were accessed through hospital databases. The AFV measurements included in our analysis were obtained using the maximum vertical pocket technique.

Results

AFV was positively correlated with EFW in the overall, male and female samples; however, the magnitude of the association was small (0.1<r<0.3). A moderate (0.3≤r<0.5) association between AFV and EFW was found specifically during mid- to late-gestation.

Conclusions

The incorporation of EFW together with other factors (e.g., gestational age, fetus sex) may increase the accuracy of the AFV cut-offs calculation and, ultimately, reduce morbidity.
Crystal structure of (Z)-2-(1-bromo-2-phenylvinyl)-5-ethyl-2-methyl-1,3-dioxane-5-carboxylic acid, C15H17Br1O4
Authors: Jia Guo-Kai , Yuan Xian-You
Published: May 2022

C15H17Br1O4, monoclinic, P21/n (no. 14), a = 7.1178(16) Å, b = 8.752(2) Å, c = 24.554(6) Å, β = 94.761(3)°, V = 1524.3(6) Å3, Z = 4, R

gt
(F) = 0.0275, wR

ref
(F
2) = 0.0694, T = 296(2) K.
QCD phase diagram in a finite volume in the PNJL model
Authors: Betancourt Francisco J. , Saucedo Jonathan Rincón , Flores-Ocampo Fidel , Flores-Baez Francisco V. , Paz Antonio , Morones-Ibarra José Rubén
Published: May 2022

In this work, we study the quantum chromodynamics phase diagram at finite temperature and non-zero chemical potential in the framework of the SU(2) flavor of the Polyakov–Nambu – Jona–Lasinio model (PNJL). Applying multiple reflection expansion to cubic and spherical finite volumes of different sizes and boundary conditions, the chiral phase transition and deconfinement of strongly interacting matter are analyzed. We give special attention to find and locate the critical endpoint and locating the critical endpoint, if it exists, as a function of the volume size and its shape, and its dependence of chemical potential and temperature.
Absenteísmo de Policiais Militares e Bombeiros Militares de Santa Catarina
Authors: Pereira Gustavo Klauberg , Ruppel da Rocha Ricelli Endrigo , Cruz Roberto Moraes
Published: May 2022

Esta pesquisa buscou analisar o perfil dos afastamentos de trabalho de policiais militares e bombeiros militares do estado de Santa Catarina no período de 2014 a 2017. O estudo está pautado no referencial teórico-metodológico da epidemiologia e caracteriza-se como um estudo descritivo, retrospectivo e de série temporal. Os dados foram produzidos a partir de análises estatísticas dos afastamentos do trabalho por motivo de saúde de 4.853 Policiais Militares e de 726 Bombeiros Militares de Santa Catarina. Foi desenvolvido um modelo de regressão logística multivariada e hierárquica e verificadas as Razões de Chance (OR) nas análises multivariáveis com seus respectivos intervalos de confiança (IC95%). No modelo hierárquico foram incluídas as variáveis sexo, atividade, organização militar e carreira como independentes. As causas do absentismo foram elencadas como variáveis dependentes. O nível de significância adotado para todas as análises foi de p0,05. Os resultados do estudo evidenciam a relação entre o absentismo e fatores sócio ocupacionais da população estudada. Predominou o afastamento de militares do sexo masculino, dos que realizavam atividade operacional, da carreira Praças e com renda abaixo de 7.360,00. Os militares que atuam na região Litorânea do estado tiveram maior número de afastamento para tratamento de saúde se comparado aos que atuam na região Serrana do estado. A população investigada neste estudo possui risco laboral elevado e necessita de especial atenção por parte das instituições devido ao aumento de número de afastamentos do trabalho no decorrer dos anos.
Saber Local e Marketing: Construindo uma definição sobre Artesanato de Experiência a partir da Grounded Theory
Authors: Souza Jade Castro , Costa Carlos Everaldo Silva , Silva Valdemir Da , Matos Beatriz Gondim , Oliveira Rodrigo César
Published: May 2022

O objetivo do estudo é construir um diálogo entre saber local (o das artesãs) e ciência (o da Administração), guiado pelo método Grounded Theory. Com ontologia idealista e epistemologia interpretativista, o lócus é a Ilha de Santa Rita, maior ilha lacustre do Brasil e uma Área de Proteção Ambiental (APA), é uma comunidade cujos frequentadores externos são os: clientes de restaurantes entre os magues; convidados de festas nos sítios margeados pelas lagoas Mundaú e Manguaba; e praticantes de remo e stand up paddle em uma escola especializada. Com abordagem qualitativa, utilizou ferramentas da GT, que remete ao reforço teórico após os achados. Sobre a coleta, os dados primários, guiados por memorandos, foram coletados junto às artesãs via observação participante, entrevistas intensivas e conversas em grupo. Já os secundários foram os produtos das artesãs. A pesquisa, entre outubro de 2018 e dezembro de 2019, interpretou relatos que revelaram a necessidade de que os produtos fossem melhores divulgados e, por mérito, o marketing reforçou tais achados. Como considerações, o estudo, que respeitou as singularidades locais, elaborou uma ação de divulgação para enfatizar a identidade visual a ser exposta naqueles espaços frequentados, emergindo a noção de artesanato de experiência.
Comparing comparison: Smith and Davidson
Authors: Gardiner Mark Q. , Engler Steven
Published: May 2022

Nos últimos anos, vários autores têm criticado a comparação, como método na ciência da religião. Grande parte da discussão aborda o que chamamos da dilema da comparação religiosa: ou as semelhanças entre os casos comparados são reais e as diferenças acidentais, ou as diferenças são reais e as semelhanças meramente aparentes. No primeiro caso, o ato da comparação impõe semelhanças de uma maneira artificial, privilegiando erroneamente uma das coisas a serem comparadas, o que pressupõe uma visão essencialista, afirmando que as suas características servem como medida de todo caso comparável. No segundo caso, as diferenças entre os casos a serem comparados são vistas como uma barreira insuperável, minando a própria premissa da comparação. Argumentamos que este aparente dilema pressupõe uma concepção representativa do significado, ou seja, que a comparação tem como meta descobrir qual tipo de coisa é representada pelos casos que estão sendo comparados. Entretanto, existem outras concepções do significado que podem potencialmente evitar ou resolver o dilema, reorientando a concepção básica de comparação, ao invés de entrar em detalhes dos recentes debates críticos. Este artigo afirma que o interpretarismo, uma abordagem do significado associada ao filósofo Donald Davidson, faz exatamente isso. JZ Smith não adotou explicitamente uma teoria semântica. Mas demonstramos que todos os seus principais elementos em seu trabalho de comparação se sustentam na base de uma visão interpretarista. As obras de Smith representam um modelo rico e detalhado de como a comparação prossegue sob uma semântica interpretativa. Este artigo tem duas implicações importantes para o estudo da religião. Primeiro, ela dissolve o dilema da comparação religiosa, sugerindo uma base teórica e metodológica mais firme para estudos comparativos. Segundo, sublinha que o trabalho de Smith serve como um modelo poderoso e prático do método comparativo, construído a partir desta base. Como corolário, oferece um benefício colateral interdisciplinar: a leitura de Smith à luz de Davidson também faz contribuições importantes para a filosofia da linguagem.
XXIX Российский национальный конгресс «Человек и лекарство». Сборник тезисов
Authors: Article Editorial
Published: May 2022

XXIX Российский национальный конгресс «Человек и лекарство».

4-7 апреля 2022 г.

Сборник тезисов.

Москва, 2022
Training of public-school managers in the light of practical reflexivity
Authors: Alves Thaís Lopes de Lucena , Bispo Marcelo de Souza
Published: May 2022

Abstract This study seeks to interpret school managers’ experiences and meanings during their training in a continuing education program offered by the government of the Brazilian state of Paraíba. The study used the constituent elements of reflexive dialogue to understand school managers’ training, obtained through participant observation during a module of a continuing education program for school managers with 35 school principals and a workload of 24 hours. The results point to a dissonance between training content and the managers’ demands and reality, creating a binomial theory vs. practice. It is also possible to identify the political problems around hiring school principals and the consequences of such a process in school management. The research concludes that the training of public managers anchored in practical reflexivity can be a mechanism to contribute to democratic management.
International development cooperation and external financing in Brazil: a macro analysis from 2000 to 2020
Authors: Pessina Maria Elisa Huber , Coelho André Pires Batista , Fadul Élvia Mirian Cavalcanti , Monteiro Augusto de Oliveira
Published: May 2022

Abstract This article analyzes public sector projects and programs in Brazil that received external financing from multilateral and bilateral agencies at the federal, state, and municipal levels between 2000 and 2020. The analyzed data were collected in the COFIEX Panel of the Brazilian Ministry of Economy, categorized, and presented in this article in a contextual way, aiming to represent the first overview of this object for studies on Public Administration in the country. An important instrument of the International Development Cooperation System, International Financing for Development follows international organizations” agendas and guidelines that have changed throughout history. Thus, in addition to exploring the main creditor sources, sectors, and federal units of destination of International Development Financing to Brazil, the article verified how the characteristics of international financing received between 2000-2015 and post-2015 reflect the agendas and guidelines of International Development Cooperation of the respective periods, namely, the Millennium Development Goals (2000-2015) and the Sustainable Development Goals (2015-2030). As a result, in addition to presenting a pioneering exploratory analysis of the data, it was possible to verify an inflection of external financing received by Brazil after 2015 in the direction of the current agenda and guidelines of International Development Cooperation. Finally, the paper presents directions for future research agendas.
Controle externo e drift institucional na Primeira República
Authors: Martins Adelino
Published: May 2022

Resumo Esta pesquisa trata do desenvolvimento das instituições federais de controle externo durante a Primeira República brasileira. É um tema pouco visitado pela bibliografia, em geral abordado em retrospectivas que compõem estudos cujos focos estão na história recente do Tribunal de Contas da União (TCU), marcada pelo advento da Nova República (1985-). Tais estudos sugerem um padrão histórico no desenvolvimento das instituições federais de controle externo, caracterizado pela alternância entre períodos de expansão e de retração de suas atribuições. O conhecimento acerca desse padrão histórico de desenvolvimento institucional, para avançar, carece do aprofundamento das pesquisas sobre o período no qual se estabeleceram as bases de sua construção: a Primeira República. Este estudo pretende ser uma contribuição à superação dessa lacuna. Ele sustenta que o desenvolvimento das instituições federais de controle externo no período em questão foi caracterizado pela expansão legal de atribuições, de 1890 a 1892, seguida pela abdicação prática dali até 1930, por drift institucional, da responsabilidade de julgar as contas anuais de governo. O estudo é institucionalista histórico e foi construído com base na análise de fontes primárias.
Behaviour of a weakly bonded residual soil subjected to monotonic and cyclic loading
Authors: Fante Fernando , Rocha Maria Mariana de Sousa , Moreira Eclesielter Batista , Prietto Pedro Domingos Marques , Rosa Francisco Dalla , Lopes Júnior Luizmar da Silva , Almeida Felipe Schaedler de , Consoli Nilo Cesar
Published: May 2022

Residual soils are found all around the world. Their behaviour is different from ‘classic’ soils due to the structure resulting from the geological formation processes, which can eventually undergo degradation under static and cyclic loads, with a decrease in both stiffness and strength. In this context, the aim of the present study was to evaluate the behaviour of weakly bonded residual soil in the face of loading and unloading cycles using field plate load tests. Preliminary field and laboratory tests were carried out to characterise the residual soil at the experimental site. Monotonic and cyclic plate load tests – with circular and square plates – were performed under three different load amplitudes. The results showed no shape effect of the loaded area for both monotonic and cyclic loading, considering the same loading pattern. Also, there is a threshold load, which indicates a yielding point and a change in soil behaviour and can be estimated from simple laboratory tests. Below this load, the residual soil presented a rigid behaviour even when subjected to cyclic loads.
COMRADE-ESS GIRL:1SUNČANA ŠKRINJARIĆ’S AUTOBIOGRAPHICALTRILOGY AS COMING OF AGE IN BETWEEN THE FEMINIST WAVES
Authors:   Central European UniveristyVienna, Austria, Stepanović Natalija
Published: May 2022

This essay analysestheautobiographical trilogy authored by a Croatian writer mostly known for her children’s stories,Sunčana Škrinjarić (1931-2004). The trilogy consists of the novels Ulica predaka [The Ancestor’s Lane], Ispit zrelosti [The Matriculation Exam], and Bijele strijele[White Arrows],published between 1980 and 2004. I interpret them as feminist Bildungsroman, a genre present both in the West and in the East, trackingthe heroine’s venture from the private into public sphere,while downplaying the importance romance and marriage had in the classic, male-centric version ofthe form. Followinganarrative analysis, I discuss Škrinjarić’s portrayal of aesthetic norms and cultural production and outline possibilities of resistance through reading and writing. The third section of the essay engages with the history of Yugoslav feminism and situates Škrinjarić withinarecently revised timeline of women’s activism that emphasizes the continuity between thegovernment-supported project of women’s emancipation and second-wave feminism. By combining textual analysis with wider cultural context,I have found thatŠkrinjarić’s still widely obscure trilogy offers valuable insights intothe formation of female identities and possible plots in which we encounter said identities
GOOD INTENTIONS:OTHERING LGBTQ LITERATURE FOR CHILDREN AND YOUNG ADULTS IN THE SLOVENIAN LITERARY SYSTEM
Authors:   Independent researcher, Zavrl Andrej
Published: May 2022

The article looks at the position of LGBTQ literature for children and young adults in the Slovenian literary system. In particular, it attempts to demonstrate thatLGBTQ texts are often written, understood and didacticized with (implicit)reference todifference, empathy, acceptance and otherness. It analyses literary and critical texts with a focus on the apparently well-meaning processes of othering found at the levels of plot, character, writers’ didactic interference, critical reception and publishing. These processesinfluence how the members of the in-group perceive the members of the out-group(both of whom can be readersand writers)andhow each see themselves. Notonly do they reflect,buttheyalsohelp shape reality and impact on the waysindividuals are treated in society.Therefore, thecriteriaof literariness, though essential, arenot absolute, and all agents in the children’s and young adult literary system should take account ofthe human/children’srightto inclusion
THE CULTURAL SHACKLES OF NORMATIVE FEMININITY THROUGH CERTAIN LITERARY AND FILM NARRATIVES
Authors:   Master of Cultural Studies in Literature, Jovkovska Ana
Published: May 2022

The contemporary challenges of culture and gender in consumer society are numerous. Through critical reflections on certain aspects of women's representation in popular culture, we will re-examine her role in society, seeking explicit and subliminal sexist messages embedded in literary and film language. Exploring the hegemony of the body, through the objectification of women and sexism, the cultural shackles of normative femininity, we will try to find gender asymmetry in the media representation and note the relationship with the ideology of consumerism and mass culture. Decoding the gender stereotypes, on the one hand, and the contemporary post-feminist transformations of femininity, on the other, we will re-examine the gender roles in popular culture by asking questions: To what extent do books and films about Bridget Jonesand The Stepford Wivesoppose the macho, sexist and patriarchal culture? Are they a rebellion against gender and structural discrimination against women? Is the criticism in those works clear and explicit or, in the attempt to detect gender stereotypes, do they in fact legitimize and strengthen them? Is it a matter of subversion, resistance or acceptance, or is it a reconciliation with the dominant values of popular culture and masculine society? Through the polysemic reading of the texts we will seek for the new meanings that are created through the juxtaposition of the code and the decoder, in the interaction between the text, the meaning, the context, the recipient and the discourse. The production of meanings extends far beyond the processes of fabrication, exchange and reproduction of culture
THE PRINCIPLES OF YUGOSLAVCULTURAL POLICY (1945-1952)
Authors:   Institute of National HistorySs. Cyril and Methodius University in Skopje, Popovska Dragica
Published: May 2022

After World War II and the formation of the new Yugoslav state, the Communist Party of Yugoslavia began to establisha new political system. In the process oftransformation of Yugoslav society, the resource of culture was crucial. The paper focuses on the basic principles upon which the cultural policy in the new Yugoslavia was built, whose specificity was largely conditioned by the current political and educational situation. Based on theavailable archival material, the paper analyzes the fundamental ideas in the specific field, in the periods before and after the conflict with the Information Bureau (Cominform). The differences between the two periodsshowhow important the social factors are in the formulation of the goals of the cultural policy. Namely, in the first years there is a strong sovietization in the cultural field, where the following of the Soviet modelsin politics is especiallynoticeable. In the 1950s began desovietization,а process that consisted of abandoning the Soviet model of cultural practices, abandonment of the ideological matrix of socialist realism and introduction of self-administrativesocialism, which would contribute to acertain democratization in the fieldof cultural production
BETWEEN LITERARY HISTORY AND AUTOPOETICS (NOTES OF TIHOMIR OSTOJIĆABOUT LITERARYPERIODICALS IN JOURNALS„STRAŽILOVO“ AND „LETOPIS MATICE SRPSKE“)
Authors:   Institute for Literature and Art Belgrade, Ćuković MilicaV.
Published: May 2022

This work has the goal to describe and analyze notes dedicated to literary periodicals, that Tihomir Ostojićhas been intensively publishing in the magazine “Stražilovo” at the end of the XIX century, as well as the notes that this historian of literature published in “LetopisMatice srpske” between 1900 and 1914. Small in size, not so big in scope, but easy to go through, informative, communicative, immanently valuable, and solely in the magazine form, everyday information, and additional information about that moment in literature, Tihomir Ostojić’s notes published in “Stražilovo” and “LetopisMatice srpske” give us a way to see the literary scene of that time. They are full of information useful for getting to know the history of Serbian literature and culture; on the other hand, these notes about literary periodicals are useful for reading and understanding Tihomir Ostojić’s autopoetics
THE LITERARY TRADITION IN THE NOVEL “THE FAMILY”BY NINA FEDOROVA
Authors:   Perm State University, Arustamova Anna A. , Borovitskaya Diana A. ,   Perm State University
Published: May 2022

The article discusses the specifics and features of the functioning of the literary tradition in the novel “The Family”by Nina Fedorovain the context of phenomenon of literarycentricity,which characterizes works of Russian émigré literati.In the work by the writer of the Russian abroad, there are many similarities with the novel by I.A.Goncharov “The Cliff”: at the level of the chronotope structure, individual images (the image of the Grandmother) and the image system as a whole, plot moves, motives, as well as stylistic devices. “The Family” is characterized by literary-centricity, it reproduces the atmosphere of the Russian manor culture and the topic of the Russian manor novel, the structural elements of Russian prose of the second half of the 19th century. Following the tradition allows the writer to keep in touch with Russian classical literature and Russian culture as a whole. At the same time, the recognition of the literary tradition reinforces the tragic register in the novel dedicated to the life of Russian emigrants of the first wave.The paper also considers some features of the poetics of the novel “The Family”: the role of symbolism in the figurative system of the work, the specifics of its spatial-temporal organization, the peculiarities of using metaphors, some characteristics of the narrative
Развитие инновационных подходов к формированию системы управления качеством в условиях индустрии 4.0
Authors: Хайдер Мохсин Мохаммед Алькхазаали
Published: May 2022

Предмет: предметом исследования являются проблемы инноваций в качестве (в принципах, инструментах и инфраструктуре управления качеством) и качества в инновациях, а также особенности организации системы управления качеством производственных компаний в условиях Индустрии 4.0. Цель: статья посвящена тому, как производственным компаниям использовать новые промышленные стандарты для управления качеством продукции и услуг в условиях Индустрии 4.0. Дизайн исследования: в статье рассмотрен переход производственных отраслей от механизации к цифровизации с помощью информационно-коммуникационных технологий, развитие которых сделало возможным интеллектуальное производство или появление концепции Индустрия 4.0. Данная концепция относится к моделям производства, включающим инновационные технологии, производственные факторы и организацию рабочей силы. Поскольку концепция Индустрии 4.0 является относительно новой, существует ограниченное количество публикаций о проблемах управления качеством в рамках Индустрии 4.0. Одной из таких проблем является вопрос модернизации системы управлении качеством в рамках Индустрии 4.0 с помощью новых промышленных стандартов. Результаты: автором разработана базовая система управления качеством на производственном предприятии с помощью двух стандартов качества (стандарт ISA-95; стандарт ISO 22400) с применением новых экономических и программных инструментов Индустрии 4.0. С помощью анализа и синтеза систематизировано распределение значений показателей по трем уровням иерархии производства (ключевые показатели эффективности; показатели эффективности; ключевые показатели результатов). В заключение сформулированы авторские рекомендации по преодолению трудностей, связанных с управлением качеством в рамках Индустрии 4.0.
[RETRACTED] Gemini Keto Gummies v1
Authors: not provided sethzrollines
Published: May 2022

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[RETRACTED] Ketogenic Maxx - New Dietary Ingredients Are Effective for Weight Loss! Price v1
Authors: Maxx Reviews Ketogenic
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[RETRACTED] What Is Open Eye Hemp CBD Gummies & How CBD Gummies Works? v1
Authors: not provided openeyehem
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