bluuebunny/crossref_metadata_2025 huggingface dataset:
Zwitterionic mesoporous engineering aids peptide-dependent pattern profiling for identification of different liver diseases
Authors: Xu Zixing , Zhang Wantong , Deng Chunhui , Sun Nianrong
Published: August 2023

Zwitterionic mesoporous engineering was developed to assist high-throughput separation and analysis of peptide patterns. Its further coupling with machine learning achieved a precise diagnosis of different liver diseases.
Non-adiabatic coupling in the potential energy surfaces of SO2 molecule
Authors: Pourestarabadi Sedigheh , Dehestani Maryam
Published: August 2023

The calculation of non-adiabatic coupling terms (NACTs) and adiabatic-to-diabatic transformation (ADT) angles between electronic states in SO2 molecule with a special focus on the intersection between 1 1A2 and 1 1B1 states.
The formation mechanism of the precursor film in high temperature molten metal systems: insight into structural disjoining pressure
Authors: Zhao Yuren , Shibahara Masahiko , Fan Xingyu , Zhang Wenhe , Liu Chong , Li Jingmin
Published: August 2023

Structural disjoining pressure has been confirmed to exist in high-temperature molten metal systems and exerts a substantial influence on the formation of molecular precursor films.
Fe-doped carbon nanotubes: towards the molecular design of new catalysts for the oxygen reduction reaction
Authors: Nuñez J. L. , Belletti G. D. , Colombo E. , Nazmutdinov R. R. , Quaino P.
Published: August 2023

Fe-doped carbon nanotubes are proposed as electrocatalysts for the oxygen reduction reaction (ORR). The armchair (5,5) Fe@CNT shows the lowest activation energy for the reaction and a superoxide anion radical (O2˙−) is formed in an adsorbed state.
Symmetry-breaking-induced ferroelectric HfSnX3 monolayers and their tunable Janus structures: promising candidates for photocatalysts and nanoelectronics
Authors: Zhang Yu , Shen Yanqing , Liu Jiajia , Lv Lingling , Zhou Min , Yang Xin , Meng Xianghui , Zhang Bing , Zhou Zhongxiang
Published: August 2023

HfSnX3 and Janus HGSS monolayers: materials with great application prospects in ferroelectric adjustable energy conversion and nano electronic devices.
Development of an oxyresveratrol incorporated bio-based smart nanocomposite coating with anti-corrosive, self-healing, and anti-microbial properties
Authors: P. R. Rajimol , Ulaeto Sarah Bill , Raj V Athira , Puthiyamadam Anoop , Sahoo Sushanta Kumar , T. P. D. Rajan , K. V. Radhakrishnan , Sukumaran Rajeev K.
Published: August 2023

Green and sustainable smart coatings with multiple functionalities that exhibit an excellent response to triggers, are essential in order to reduce energy consumption, usage of fossil resources, and to enhance economic impact.
Recent advancements in supramolecular macrocycles for two-dimensional membranes for separations
Authors: Cheng Shi-Qi , Lin Qian , Li Shu-Lan , Guo Ya-Xiao , Han Xiao-Le , Sun Yue , Liu Yi
Published: August 2023

This review summarizes recent advancements of 2D supramolecular membranes for separations. This topic can provide new insights on developing 2D supramolecular membranes with high selectivity, mild flux, good stability and appreciable reversibility.
Sample preconcentration through airjet-induced liquid phase enrichment
Authors: Wang Edward , Laurent Louise C. , Hall Drew A. , Lo Yu-Hwa
Published: August 2023

An evaporative, airjet-based method which reverses the coffee-ring and enables enrichment of diverse molecules and particles in liquids. The method is used as sample preconcentration step for improved detection performance in nucleic acids assays.
Insight into the evolution upon ionization from tin-oxo cage photoresist and counterions by DFT calculation
Authors: Yang Fang-Ling , Ye Zong-Biao , Chen Yu-Qi , Wang Ming-Hui , Zhou Pan-Pan , Gou Fu-Jun
Published: August 2023

The tin-oxo cage ([R12Sn12O14(OH)6]2+) is an excellent photoresist candidate in extreme ultraviolet lithography (EUVL). And its' performance is closely related to the counterions.
Perylene diimide with solid-state NIR luminescence for imaging of latent fingerprints (sweat pores)
Authors: Kaur Navdeep , Singh Prabhpreet
Published: August 2023

PDI 2 showed near-IR emission at 683 nm, 99.53% red colour purity and a thick film morphology with holes for daylight and fluorescence imaging of fingerprints (levels 1–3).
Enhancing the photo-driven seawater splitting performance of hierarchical TiO2 through rich surface hydroxyl and oxygen vacancy design
Authors: Zhang Ya-Jiao , Xiao Shi-Tian , Wang Yi-Tian , Wu Feng-Juan , Wu Si-Ming , Wu Lu , Pu Fu-Fei , Wang Li-Ying , Tian Ge , Huang Cong-Yun , Yang Xiao-Yu
Published: August 2023

Hierarchical TiO2 nanofibers exhibit excellent H2 production activity and stability in seawater owing to the enhanced charge transfer and fast H+ adsorption by the synergistic effects of surface hydroxyls and oxygen vacancies.
A reliable QSPR model for predicting drug release rate from metal–organic frameworks: a simple and robust drug delivery approach
Authors: Tayebi Leila , Rahimi Rahmatollah , Akbarzadeh Ali Reza , Maleki Ali
Published: August 2023

A simple and robust QSPR model has been established to estimate the drug release rate from metal–organic frameworks.
Anchoring ultrasmall Pd nanoparticles by bipyridine functional covalent organic frameworks for semihydrogenation of acetylene
Authors: Zhang Ji-qiu , Wang Yu-Hao , Zhang Shu-jing , Lin Yang-qian , Guan Qing-qing , Xu Xi-meng
Published: August 2023

Acetylene hydrogenation is a well-accepted solution to reduce by-products in the ethylene production process, while one of the key technical difficulties lies in developing a catalyst that can provide highly dispersed active sites.
Superhalogen modulation: an effective approach for minimizing light-induced halide segregation in MAPb(I0.7Br0.3)3
Authors: Nandi Pronoy , Park Hyoungmin , Shin Sooeun , Sharbirin Anir S. , Kim Jeongyong , Kwon Seok Joon , Park Nam-Gyu , Shin Hyunjung
Published: August 2023

We identify an efficient method to suppress halide segregation by adding BF4− as a modulator into MAPbI2.1Br0.9. Improved device performance indicate BF4−-incorporation is beneficial for the mitigation of defect trapping and halide ion hopping.
An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperatures
Authors: Romero-Reyes Andrea , Hernandez-Leon Sergio G. , Leyva-Carrillo Lilia , Yepiz-Plascencia Gloria , Reynolds Matthew P. , Paul Matthew J. , Heuer Sigrid , Valenzuela-Soto Elisa M.
Published: August 2023

High temperatures in the field hinder bread wheat high-yield production, mainly because of the adverse effects of heat over photosynthesis. The Yaqui Valley, the main wheat producer region in Mexico, is a zone prone to have temperatures over 30°C. The aim of this work was to test the flag leaf photosynthetic performance in 10 bread wheat genotypes grown under high temperatures in the field. The study took place during two seasons (2019–2020 and 2020–2021). In each season, control seeds were sown in December, while heat-stressed were sown in late January to subject wheat to heat stress (HS) during the grain-filling stage. HS reduced Grain yield from 20 to 58% in the first season. HS did not reduce chlorophyll content and light-dependent reactions were unaffected in any of the tested genotypes. Rubisco, chloroplast fructose 1,6-biphosphatase (FBPase), and sucrose phosphate synthase (SPS) activities were measured spectrophotometrically. Rubisco activity did not decrease under HS in any of the genotypes. FBPase activity was reduced by HS indicating that triose phosphate flux to starch synthesis was reduced, while SPS was not affected, and thus, sucrose synthesis was maintained. HS reduced aerial biomass in the 10 chosen genotypes. Genotypes SOKWB.1, SOKWB.3, and BORLAUG100 maintained their yield under HS, pointing to a potential success in their introduction in this region for breeding heat-tolerant bread wheat.
Measuring Articulatory Patterns in Amyotrophic Lateral Sclerosis Using a Data-Driven Articulatory Consonant Distinctiveness Space Approach
Authors: Teplansky Kristin J. , Wisler Alan , Green Jordan R. , Heitzman Daragh , Austin Sara , Wang Jun
Published: August 2023

Purpose:

The aim of this study was to leverage data-driven approaches, including a novel articulatory consonant distinctiveness space (ACDS) approach, to better understand speech motor control in amyotrophic lateral sclerosis (ALS).

Method:

Electromagnetic articulography was used to record tongue and lip movement data during the production of 10 consonants from healthy controls (
n
= 15) and individuals with ALS (
n
= 47). To assess phoneme distinctness, speech data were analyzed using two classification algorithms, Procrustes matching (PM) and support vector machine (SVM), and the area/volume of the ACDS. Pearson's correlation coefficient was used to examine the relationship between bulbar impairment and the ACDS. Analysis of variance was used to examine the effects of bulbar impairment on consonant distinctiveness and consonant classification accuracies in clinical subgroups.

Results:

There was a significant relationship between the ACDS and intelligible speaking rate (area,
p
= .003; volume,
p
= .010), and the Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised (ALSFRS-R) bulbar subscore (area,
p
= .009; volume,
p
= .027). Consonant classification performance followed a consistent pattern with bulbar severity, where consonants produced by speakers with more severe ALS were classified less accurately (SVM = 75.27%; PM = 74.54%) than the healthy, asymptomatic, and mild–moderate groups. In severe ALS, area of the ACDS was significantly condensed compared to both asymptomatic (
p
= .004) and mild–moderate (
p
= .013) groups. There was no statistically significant difference in area between the severe ALS group and healthy speakers (
p
= .292).

Conclusions:

Our comprehensive approach is sensitive to early oromotor changes in response due to disease progression. The preserved articulatory consonant space may capture the use of compensatory adaptations to counteract influences of neurodegeneration.

Supplemental Material:

https://doi.org/10.23641/asha.22044320
Large Interferometer For Exoplanets (LIFE)
Authors: Matsuo Taro , Dannert Felix , Laugier Romain , Quanz Sascha P. , Kovačević Andjelka B. ,   LIFE Collaboration
Published: August 2023

Context.A mid-infrared nulling-space interferometer offers a promising way to characterize thermal light from habitable planet candidates around Sun-like stars. However, one of the main challenges inherent in achieving this ambitious goal is the high-precision stability of the optical path difference and amplitude over a few days for planet detections and all the way up to a few weeks for in-depth characterization. This is related to mission parameters such as aperture size, number of apertures, and total instrument throughput.

Aims.Here, we propose a new method called phase-space synthesis decomposition (PSSD) to shorten the stability requirement to a scale of minutes, significantly relaxing the technological challenges of the mission.

Methods.By focusing on the consideration of what exactly modulates the planetary signal in the presence of the stellar leak and systematic error, PSSD prioritizes the modulation of the signals along the wavelength domain rather than baseline rotation. Modulation along the wavelength domain allows us to extract source positions in parallel to the baseline vector for each exposure. The sum of the one-dimensional data is converted into two-dimensional information. Based on the reconstructed image, we constructed a continuous equation and extract the spectra through the singular value decomposition, while efficiently separating them from a long-term systematic stellar leak.

Results.We performed numerical simulations to investigate the feasibility of PSSD for the Large Interferometer For Exoplanets (LIFE) mission concept. We confirm that multiple terrestrial planets in the habitable zone around a Sun-like star at 10 pc can be detected and characterized despite high levels and long durations of systematic noise. We also find that PSSD is more robust against a sparse sampling of the array rotation compared to purely rotation-based signal extraction. Using PSSD as signal extraction method significantly relaxes the technical requirements on the signal stability and further increases the feasibility of the LIFE mission.
Social representations about sexuality after cancer: A sociological perspective integrating life and earth sciences
Authors: El Ghali Maryama , Borj Fouzia
Published: August 2023

Cancer and sexuality are two complex and intimately linked fields that give rise to different social representations, influencing the way their sexualities are approached. People with cancer may face challenges that influence their sex lives due to the adverse effects of the disease and its treatments. And because of alterations in identity, body image and taboos surround their sexualities. These factors can contribute to negative perceptions about sexuality in cancer patients. It is essential to understand and recognize the various social representations in order to provide adequate support to people with dementia, while integrating a mixed methodology, through life stories with people with dementia, as well as questionnaires dealing with the sexuality axis. Stereotypes, prejudices, and social norms can contribute to stigmatization of these patients, and to the reinforcement of taboos, which can limit open discussion about sexuality during and after cancer and the enjoyment of a fulfilling and pre-cancer life. For an in-depth study of sexuality and cancer, it is imperative to adopt a multidisciplinary approach and collaboration between the social sciences, life sciences and earth sciences, through a sociological perspective.
The law of medically assisted procreation-the history of a legal framework to boost fertility in the face of environmental constraints in Morocco
Authors: Ghallam Aziza , Bouasria Leila , Zirar Hayat
Published: August 2023

For the first time, the Moroccan legislator officially regulated the use of medically procreative techniques in 2019, allowing couples affected by infertility to conceive outside the ordinary biological process. Aspiring relatives are betting on Law 47-14 on medically assisted procreation (ART) to facilitate access to infertility care. This article aims to demonstrate the contributions and limitations of this law and to understand its impact on the lives of infertile couples. In addition, this work highlights the position of the various parties involved in the implementation of this legislation after a controversial debate. Methodologically, we opted for a qualitative method based on reading parliamentary archives, writings, and audiovisual media, coupled with semi-structured interviews with the various stakeholders in the field of GPA. 91.7% of participants, infertile couples and practitioners of medically assisted procreation place the lack of financial reimbursement of ART acts at the top of their concern. Similarly, health professionals criticize the disciplinary sanctions stipulated in the law. Despite the strengths of this legal framework, it has not provided a solution to fight against socio-economic and gender inequalities related to access to GPA in Morocco.
Green logistics for sustainable development: The challenge of general price increases
Authors: Lazrak Mariam , El Amrani Hamid
Published: August 2023

Green logistics is the process of reducing the environmental footprint of a product throughout its life cycle. The level of interest in this approach is growing and companies are increasingly concerned about environmental issues. When we talk about a green supply chain, we often tend to associate it specifically with road transport. However, green thinking can be applied to all links in the supply chain, from supply to distribution green logistics consists of integrating an ecological approach into the management of logistics processes in order to reduce their impact on the environment. This extends over the entire life cycle of the product: manufacturing, storage, transport, placing on the market, use, and destruction. On the other side, the health crisis has disrupted the various supply chains since the confinement end and the resumption of activities on construction sites has forced companies to supply themselves with material where production had resumed, thus leading to a rise in prices. The objective of this article is to study the general effect of rising raw material prices on green logistics.
Diagnosis of learning difficulties of plate tectonics concepts among secondary school students using: Focus group, nominal group, and questionnaire
Authors: En-Nhili Larbi , Boubih Saïd , Amiri Mostafa , El Alaoui Mustafa
Published: August 2023

The teaching of geology or earth sciences occupies an important place in the life and earth sciences programs of the secondary cycle in Morocco. The theory of plate tectonics is the conceptual model that allows an understanding of most of the dynamic processes of the Earth. Our work aims to diagnose the difficulties related to the learning of the concepts related to plate tectonics by following a hybrid methodology of three techniques, namely: focus group, nominal group, and questionnaire. The results obtained allowed us to identify difficulties in the educational act in its different facets, whether epistemological, pedagogical, didactic, curricular, and logistical. These difficulties should be taken into consideration by the different actors in the educational process, in order to guarantee the successful learning of this discipline.
Public management at the service of improving energy optimization: Case of Moroccan universities
Authors: Laasri T. , Boudallaa I. , Madhat F. , Khoulji S. , Bourekkadi S.
Published: August 2023

Public management can play an important role in improving the energy optimization of Moroccan universities. By adopting efficient management practices and implementing appropriate energy policies, universities can reduce their energy consumption, decrease their carbon footprint and realize financial savings., while taking into consideration the examples or the cases of the universities having shared their experiences. Among the elements that we have noticed present in the majority of university establishments is the presence of a long-term energy strategy for universities, setting clear objectives in terms of reducing energy consumption and greenhouse gas emissions. This strategy should include specific measures such as installing energy efficient lighting systems, using renewable energy sources, improving the efficiency of heating, ventilation and air conditioning systems. In this article we will try to emphasize the key elements of the success of public management with reference to energy optimization by taking into consideration the case of Moroccan universities.
Le statut de la nature de la science dans les conceptions des enseignants des sciences de la vie et de la terre au Maroc
Authors: Seghir H. , Boucetta N. , Boubih S. , El Alaoui M. , Idrissi R. Janati , Ghariz G.
Published: August 2023

Dernièrement, les finalités de l’enseignement des sciences sont évoluées vers le développement des citoyens dotés d’une culture scientifique et capables de piloter l’essor des pays. Et pour avoir une culture scientifique (l’objectif de tout enseignement scientifique), il faut posséder la connaissance et la compréhension des concepts et des processus scientifiques nécessaires pour prendre des bonnes décisions sur des questions personnelles et sociétales. En outre, la compréhension de ces constructions épistémologiques appelés nature de la science (NOS) par les enseignants est très importante pour améliorer la compréhension des sciences par les élèves Cette étude explore et analyse l’idée de science chez des enseignants Marocains des sciences de la vie et de la terre. Des entretiens semi-structurés et une analyse qualitative du contenu sont utilisés pour explorer ces idées. Les enseignants ont montré une certaine hétérogénéité des conceptions. Ces derniers ont des idées différentes sur la science. Parfois suffisantes, parfois incorrectes. Ainsi, cette étude met en évidence une carence culturelle profonde en matière de réflexion sur la nature de la science et les modes d’élaboration du savoir scientifique. D’où l’importance de l’introduction de l’épistémologie dans la formation de ces enseignants.
L’innovation comme déterminant de la résilience organisationnelle en temps de crise : cas du secteur de l’énergie au Maroc
Authors: Cheggag Meryem , Mokhlis Chams-Eddoha
Published: August 2023

En dépit des progrès scientifiques et techniques réalisés au cours des dernières décennies, le monde est de plus en plus confronté à l’incertitude, à l’imprévisibilité et à la complexité des phénomènes. A titre d’exemple, la situation complexe et singulière provoquée par la COVID-19 a interpellé les organisations sur leur capacité d’innovation, de continuité d’activité et de résilience face à l’adversité. L’innovation est le processus par lequel de nouvelles idées, produits, services ou méthodes sont développés, mis en oeuvre et adoptés. La résilience renvoie, quant à elle, à la capacité d’une entreprise à s’adapter et à se relever face aux chocs et aux perturbations. Malgré l’abondance des travaux de recherche sur la résilience organisationnelle et l’innovation, très peu ont abordé la relation entre ces deux concepts, encore moins dans le contexte marocain. L’objectif de cet article est d’analyser la relation entre ces deux concepts clés et d’explorer comment l’innovation peut constituer un levier de résilience organisationnelle en temps de crise. Pour ce faire, nous avons mené une étude qualitative, à travers des entretiens semi-directifs auprès d’entreprises marocaines opérant dans le secteur de l’énergie. Les principaux résultats confirment l’existence d’une corrélation positive entre les deux concepts. Toutefois, l’innovation ne permet pas de garantir, à elle seule, la sortie de crise et la résilience des entreprises. Afin de valider et généraliser les résultats obtenus, nous recommandons de mener une étude quantitative confirmatoire. Cet article a fait l’objet de traduction dans plusieurs langues.
Les attitudes des enseignants des ISPITS du Maroc envers l’évaluation formative : cas des enseignants intervenants au sein de l’option santé et environnement
Authors: El Filali Saadia , Assermouh Jalal
Published: August 2023

L’évaluation formative des enseignements et apprentissages constitue une innovation pédagogique au niveau de nombreux systèmes éducatifs dans le monde à l’instar de la Suisse, la France et le Québec. Au Maroc, les instituts supérieurs des professions infirmières et techniques de santé (ISPITS) ont instauré l’évaluation formative (E/F) dans le cursus de formation des apprenants, dont l’option de santé et environnement (S/E) fait partie. Notre étude exploratoire auprès des enseignants de cette option au niveau des ISPITS vise à examiner l’état des lieux des pratiques relatives à ce type d’évaluation au niveau de ces instituts. Cette recherche a révélé que la majorité des enseignants n’utilisent pas des outils de l’évaluation formative, plus que la moitié jugent que cette évaluation augmente leur charge de travail, et presque la moitié déclarent que l’évaluation formative intéresse à la fois les enseignants et les apprenants, alors que la moitié des enseignants sont d’accord à ce que l’évaluation formative soit opérationnalisée systématiquement dans le processus de formation. Notre étude a révélé l’existence d’un écart entre ce qui est prescrit dans les descriptifs conçus et validés par les instances compétentes et la réalité des pratiques évaluatives ciblées par cette étude. Nous estimons que la diminution de cet écart va surement contribuer au développement des compétences spécifiques des apprenants en responsabilité environnementale et protection de l’environnement.
Les formes de vie après la rémission d’un cancer dans le contexte casablancais
Authors: Toufik Khadija , Houssam Touria
Published: August 2023

Notre étude porte sur les formes de vie après la rémission d’un cancer. Nous utilisons une approche qualitative pour la collecte des données et complétons notre recherche par une approche quantitative. Les entretiens semi-directifs nous permettent de comprendre comment les personnes atteintes du cancer, malades ou en rémission, perçoivent leur propre expérience avec la maladie, ce qui nous permet d’identifier leurs représentations des produits de soins. Le questionnaire nous aide à comprendre l’évolution des relations familiales de ces individus tout au long de leur maladie. Nous collectons les données en personne, via WhatsApp et par le biais d’un questionnaire. Les données révèlent des changements dans les profils de nos participants après leur expérience avec le cancer. La majorité d’entre eux affirment que leur personnalité s’est améliorée, tandis qu’une minorité déclare avoir connu un changement négatif dans leur personnalité à la suite de leur maladie. Ces résultats pourraient être attribués à des facteurs qui influencent les perceptions de nos participants. Notre recherche met également en évidence des changements dans les liens familiaux de nos participants, avec une diminution des liens fraternels et un renforcement des liens conjugaux. Le nouement et le dénouement des liens familiaux des personnes atteintes du cancer contribuent à la rémission ou la récidive de l’état sanitaire de ces personnes-là.
Facteurs prédicteurs de la mortalité périnatale suite à l’asphyxie & environnement de naissance : étude cas-témoins
Authors: Yakini Souad , Amane Mounia , Bou-Iselmane Maryama , Elghazouani Hanane , Iziki Hayat , Elqadiri Ichraq , Boutasoumaat Kaoutar , Bouaiti Elarbi , Barkat Amina
Published: August 2023

L’asphyxie périnatale (AP) est une cause importante de mortalité et de morbidité lourdes, et/ ou à long terme; Chaque année dans le monde, l’OMS estime que l’AP entraine environ 4 millions des décès néonataux et un million d’enfants sévèrement handicapés;

La présente recherche a ciblé de bien déterminer les facteurs prédicteurs de la mortalité périnatale suite à l’asphyxie périnatale. C’est une étude cas témoins non apparié menée au niveau de la maternité du centre hospitalier universitaire Mohamed VI de Marrakech. Au cours de la période allant du 1avril 2022 au 30 juin 2022, 157 nouveau-nés atteints d’AP ont été inclus dans l’étude avec 31 cas et 126 témoins. Un cahier d’observation renfermant les données sociodémographiques, cliniques et biologiques des nouveau-nés a bien servit de base pour la collecte des données nécessaires.

Relativement aux résultats obtenus, plusieurs facteurs prédicteurs ont été associés significativement à la mortalité périnatale : les antécédents maternels [ (ORA =31,876, 95%, CI : (1,346; 755,149)]; le retard de croissance intra-utérin [(ORA= 4711,799), 95%, IC : ( 48,964, 453416,766)]; le score d’Apgar après 5 min : inferieur ou égale à 3 : [(ORA=139,75), 95%, CI : (16,523; 1182,01)], et les malformations congénitales : [(ORA=241,435), 95%, CI : (6,044; 9644,748)].

Plusieurs suggestions émergent, l’identification précoce des nouveau-nés à haut risque d’AP, et la mise en place des mesures efficaces de prévention, de diagnostic et de la prise en charge, sont tous des mesures cruciales afin d’éviter les complications délétères de l’AP dont la plus redoutable est la mortalité périnatale.
L’analyse des pratiques enseignantes : professionnalisation et réflexivité des futurs enseignants de FLE
Authors: Baggar Sihame , Rizk Khalid
Published: August 2023

L’enseignement des langues au Maroc ; en l’occurrence la langue française; est un sujet qui nécessite davantage de réflexion et d’analyse; en vue des approches didactiques et méthodologies d’apprentissage, en prenant en considération les mutations et les défis contemporains de la société marocaine. En outre, l’intégration de l’approche de l’analyse des pratiques enseignantes (APE) dans la formation initiale et continue des enseignants, est un processus d’optimisation de l’enseignement de la langue française afin de promouvoir la professionnalisation des enseignants. L’Analyse des Pratiques Professionnelles (APP) est un dispositif qui permet aux spécialistes d’échanger collectivement sur leur activité afin d’apercevoir des solutions aux problématiques rencontrées quotidiennement. .L’APP se développe le plus dans les secteurs où prédomine l’aspect relationnel ; les intervenants du secteur éducatif particulièrement sont concernés. De surcroît, l’APE favorise une alliance entre les savoirs essentiels à l’action professionnelle et la complémentarité entre les différents acteurs, afin de préparer au mieux les enseignants en formation et les initier à une démarche réflexive de leurs pratiques enseignantes. De ce fait, la littérature sur l’approche réflexive indique que l’APE renforce l’efficacité d’enseignement, ce qui reflète positivement la capacité des enseignants à atteindre les objectifs assignés. Ce texte s’inscrit dans un cadre didactique dans l’objectif de mettre en exergue les postures réflexives adoptées par les enseignants.
TICE et formation pédagogique des enseignants : une approche intégrée Cas de I’enseignement primaire : région Fès – Mèknes
Authors: Btissam Idrissi Loukli , Aziz Babounia
Published: August 2023

L’évolution technologique et la réalité virtuelle mènent à une transformation fondamentale des modes d’enseignement. Les enseignants d’aujourd’hui ne sont pas ceux de demain. Conscient de l’importance d’innovation technologique et numérique dans l’enseignement ; L’éducation au Maroc a connu des changements radicaux en manière et méthodes d’enseignement grâce aux différents reformes structurelles. L’une des principales réformes a été le lancement du Programme de modernisation de l’enseignement (PME) en 2022, qui ambitionne à rénover la manière de l’enseignement primaire et à encourager les élèves à participer à des activités créatives et à des projets liés à l’éducation. Cet article examine un état des lieux de la manière d’insertion des TICE chez les enseignants primaires du secteur publique. Plus spécifiquement, il vise à mieux présenter les liens entre la formation initiale en matière des TICE ; les équipements informatiques et leur utilisation par les enquêtés.
Altered Gene Expression of Cytochrome P450 and ABC Transporter in Human Hepatocellular Carcinoma HepG2 Cells Exposed to Bardoxolone Methyl
Authors: Nagai Katsuhito , Fukuno Shuhei , Miura Takeshi , Yasuda-Imanishi Eri , Konishi Hiroki
Published: August 2023

Bardoxolone methyl (BX) is expected to be an innovate therapeutic agent for chronic kidney disease (CKD). The aim of the present study was to examine whether the expression of subtypes of cytochrome P450 (CYP) and ABC transporters was altered in human hepatocellular carcinoma HepG2 cells by exposure to BX. The expression of mRNAs for CYP1A2, CYP2E1, P-glycoprotein, multidrug resistance-associated protein 1–3, and breast cancer resistance protein was significantly increased by exposure of HepG2 cells to BX, while the expression of CYP3A4 mRNA was significantly decreased under the same conditions. BX had no significant effect on the expression of mRNAs for CYP2C9 and CYP2C19 in HepG2 cells. In conclusion, this study demonstrated that the gene expression of several CYPs and ABC transporters in HepG2 cells was altered when exposed to BX, suggesting the need to pay careful attention to drug-drug interactions in patients receiving BX for CKD treatment.
Die Bedeutung von Kumpantieren für Opioidabhängige in Substitutionstherapie
Authors: Schulze Michael Christian
Published: August 2023

Ziel Viele Opioidabhängige haben Kumpantiere. In der Studie wird untersucht, welche Rolle sie in ihrem Leben spielen und welchen Einfluss sie auf die Suchterkrankung ausüben. Der Begriff Kumpantier unterstreicht, dass zwischen Mensch und Tier eine enge Beziehung besteht.

Methodik Alle substituierten Opioidabhängigen aus zwei suchtmedizinischen Praxen in Berlin wurden befragt, ob sie Tiere besitzen. Mit 12 tierhaltenden Abhängigen wurden leitfadengestützte Interviews geführt, ergänzt durch einen Kurzfragebogen. Die Auswertung erfolgte mit der qualitativen Inhaltsanalyse.

Ergebnisse 27 von 104 substituierten Opioidabhängigen (26%) besitzen Tiere, v. a. Katzen und Hunde. Für die 12 Befragten spielen die Tiere eine entscheidende Rolle in ihrem Leben. Sie weisen ihnen eine Aufgabe und Verantwortung zu, strukturieren ihren Tag, unterstützen sie emotional und lenken sie von negativen Gedanken und Gefühlen ab. Sie scheinen auch die Rückfallgefahr sowie den Suchtdruck zu mindern. Gegenüber den positiven Wirkungen der Tiere treten die negativen in den Hintergrund.

Schlußfolgerungen Auf Grund ihrer hohen Bedeutung für die Abhängigen sollten Kumpantiere in die Überlegungen und Strategien der Behandlungsteams einbezogen werden und mehr Einrichtungen der Gesundheits- und Suchthilfe einen Zugang mit Tieren ermöglichen.
GC-MS analysis and in silico docking of constituents of Cinnamomum
malabatrum against CYP450 17α and CYP450 19 (Aromatase)- Key targets for
hyperandrogenism
Authors: Soumya V. , Deepa S. , Thachil Knolin.K. , Saravanan J. , Hariprasad R.
Published: August 2023

Poly cystic ovary syndrome (PCOS) is considered as one of the common hormonal
disorders affecting 6–20% of women in their reproductive age
with characteristic features include anovulatory infertility, hyperandrogenism,
cystic follicles and insulin resistance. The gene CYP play an important role in
pathophysiology of hyperandrogenism associated with PCOS. An elevated androgens
are reported in PCOS condition due to overexpression of the enzyme
CYP450 17 α. As well as diminished levels of
aromatase (CYP450 19) were observed in several hyperandrogenic PCOS
patients. The powdered leafy material of Cinnamomum malabatrum was
subjected to Soxhlet extraction. The plant extract was subjected to Gas
chromatography-MS analysis (GC-MS), and the chromatogram obtained revealed the
presence of active chemical constituents like 1(10),9(11)-B-Homolanistadiene for
the first time and other potential compounds. Hypothesis has raised to interpret
the efficiency of phytoconstituents of Cinnamomum malabatrum on these
enzyme targets and which may be a novel drug candidate for the treatment and
maintenance of hyperandrogenism associated with PCOS. Thus, the results obtained
from the in-silico study of Cinnamomum malabatrum leaf extract
using computational approaches indicate that the phytoconstituents have good
affinities for the selected two key targets. ADME and PASS studies has been
performed for active phytoconstituents homolanistadiene, β-sitosterol,
cycloartenol and a pyrazole derivative, and results revealed the Lipinski
drug-likeness and pharmacological potential. In conclusion, this work throws a
new insight into the possibility of the active phytoconstituents on binding the
two active CYP45017 α and CYP45019 aromatase
enzymes which facilitates development of novel compounds for hyperandrogenism
associated with PCOS.
A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications
Authors: Alheety Mustafa A. , Mohammed Leqaa A. , Farhan Mohammed Alwan , Dadoosh Safaa A. , Majeed Abdulwahhab H. , Mahmood Ali Saadon , Mahmoud Zaid H.
Published: August 2023

Benzimidazole is a heterocyclic compound that contains two nitrogen atoms and is formed by fusing a benzene ring with an imidazole. Benzimidazole and its derivatives are prepared in a range of ways, including condensation of o-phenylenediamine with carbonyl compounds (aldehydes and ketones) or with carboxylic acids and their derivatives. Benzimidazoles can also be prepared by rearranging other heterocyclic compounds such as quinoxaline derivatives and triazole derivatives. In recent decades, benzimidazoles have been prepared using green methods such as microwaves and ultrasound, the use of environmentally friendly catalysts, and by using photochemical reactions. Benzimidazoles have attracted the interest of scientists and researchers due to the great medical efficacy exhibited by such derivatives against various diseases. The benzimidazole derivatives show many pharmacological activities such as anticancer, anti-inflammatory, antioxidant, anticoagulant, and antiviral action. This review focuses on benzimidazole and its derivatives, the most important methods used for its preparation, as well as the biological applications of the compound in our daily lives.

1 Introduction

2 Imidazole and Benzimidazole

3 Methods of Synthesis of Benzimidazole Derivatives

3.1 Condensation of 2-Aminoaniline (o-Phenylenediamine)

3.2 Via Rearrangement

3.3 Green Synthesis of Benzimidazole

4 Biological Activity of Benzimidazole Derivatives

4.1 Anticancer Activity

4.2 Anti-inflammatory Activity

4.3 Antioxidant Activity

4.4 Anticonvulsants Activity

4.5 Anticoagulants Activity

4.6 Antimicrobial Activity

4.7 Other Biological Applications

5 Conclusion
Comparative diagnostic yield of different endoscopic techniques for tissue sampling of upper gastrointestinal subepithelial lesions: a network meta-analysis
Authors: Facciorusso Antonio , Crinò Stefano Francesco , Fugazza Alessandro , Carrara Silvia , Spadaccini Marco , Colombo Matteo , Ramai Daryl , Mangiavillano Benedetto , Chandan Saurabh , Gkolfakis Paraskevas , Mohan Babu , Hassan Cesare , Repici Alessandro
Published: August 2023

Background There is limited evidence on the comparative diagnostic performance of endoscopic tissue sampling techniques for subepithelial lesions. We performed a systematic review with network meta-analysis to compare these techniques.

Methods A systematic literature review was conducted for randomized controlled trials (RCTs) comparing the sample adequacy and diagnostic accuracy of bite-on-bite biopsy, mucosal incision-assisted biopsy (MIAB), endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), and EUS-guided fine-needle biopsy (FNB). Results were expressed as relative risk (RR) and 95%CI.

Results Eight RCTs were identified. EUS-FNB was significantly superior to EUS-FNA in terms of sample adequacy (RR 1.20 [95%CI 1.05–1.45]), whereas none of the other techniques significantly outperformed EUS-FNA. Additionally, bite-on-bite biopsy was significantly inferior to EUS-FNB (RR 0.55 [95%CI 0.33–0.98]). Overall, EUS-FNB appeared to be the best technique (surface under cumulative ranking [SUCRA] score 0.90) followed by MIAB (SUCRA 0.83), whereas bite-on-bite biopsy showed the poorest performance. When considering lesions <20 mm, MIAB, but not EUS-FNB, showed significantly higher accuracy rates compared with EUS-FNA (RR 1.68 [95%CI 1.02–2.88]). Overall, MIAB ranked as the best intervention for lesions <20 mm (SUCRA score 0.86 for adequacy and 0.91 for accuracy), with EUS-FNB only slightly superior to EUS-FNA. When rapid on-site cytological evaluation (ROSE) was available, no difference between EUS-FNB, EUS-FNA, and MIAB was observed.

Conclusion EUS-FNB and MIAB appeared to provide better performance, whereas bite-on-bite sampling was significantly inferior to the other techniques. MIAB seemed to be the best option for smaller lesions, whereas EUS-FNA remained competitive when ROSE was available.
Serological Screening for Celiac Disease and Gastrointestinal
Absorption Disorders in Patients with Autoimmune Endocrine
Diseases
Authors: Akkurt Kocaeli Aysen , Cander Soner , Gül Özen Öz , Sisman Pınar , Ersoy Canan , Erturk Erdınc
Published: August 2023

Celiac disease (CD) accompanying autoimmune endocrine diseases (AED) is generally
asymptomatic. This study aimed to evaluate the frequency of clinically overt or
silent CD in patients diagnosed with autoimmune endocrinopathy and the clinical
effects of silent CD in these endocrinopathies. The study included 166 patients
with known or newly diagnosed mono-/polyglandular AED and 90 age- and
gender-matched healthy controls. The patients were classified into four groups:
type 1 diabetes mellitus (DM) (n=44), Hashimoto’s thyroiditis
(HT) (n=68), Addison’s disease (AD) (n=17), and
autoimmune polyglandular syndrome (APS) (n=37). All subjects were
serologically screened for tissue transglutaminase antibody (tTG) IgA and IgG.
In addition, to evaluate the possible systemic consequences of CD, serum
parathormone (PTH), 25-hydroxicholecalsiferol (25-OH-Vit D), vitamin B12, folic
acid, iron, iron-binding capacity (IBC), and ferritin levels were measured. In
the total series, 193 (75.4%) individuals were females, and 63
(24.6%) were males. TTG IgA antibody positivity was found in 23 among
166 patients, while no positivity was encountered in the healthy control group.
The highest rates of positive tTg IgA frequency were detected in AD, with
29.4% (5/17). Serum 25-OH-Vit D, vitamin B12, folic acid, iron,
and ferritin levels were significantly lower in AEDs compared to controls
(p<0.001), and the lowest these parameters were detected in patients
with AD. The serologic CD prevalence is higher in autoimmune mono-/and
polyglandular endocrine diseases than in the control group. The data support
recommends regular screening for CD in all patients with AEDs.
Functionalized Aza-BODIPYs and Their Use in the Synthesis of Aza-BODIPY-Based Complex Systems
Authors: Ravikanth Mangalampalli , Yadav Bharti
Published: August 2023

In this account, we present syntheses of various functionalized aza-boron-dipyrromethene dyes (aza-BODIPYs) in which the functional groups are directly introduced at the 2- or 6-positions of the aza-BODIPYs or on aryl rings present at the 1-, 3-, 5-, and 7-positions of the aza-BODIPYs. Some of these functionalized aza-BODIPYs have been used for the synthesis of aza-BODIPY-based energy-transfer cassettes and light-harvesting complexes.

1 Introduction

2 Monofunctionalized Aza-BODIPYs

2.1 2-/6-Monofunctionalized Aza-BODIPYs

2.2 1-/3-/5-/7-Monofunctionalized Aza-BODIPYs

3 Difunctionalized Aza-BODIPYs.

3.1 2,6-Difunctionalized Aza-BODIPYs

3.2 3,5-Difunctionalized Aza-BODIPYs

3.3 1,7-Difunctionalized Aza-BODIPYs

4 Miscellaneous

5 Conclusion
Age-related bias and artificial intelligence: a scoping review
Authors: Chu Charlene H. , Donato-Woodger Simon , Khan Shehroz S. , Nyrup Rune , Leslie Kathleen , Lyn Alexandra , Shi Tianyu , Bianchi Andria , Rahimi Samira Abbasgholizadeh , Grenier Amanda
Published: August 2023

There are widespread concerns about bias and discriminatory output related to artificial intelligence (AI), which may propagate social biases and disparities. Digital ageism refers to ageism reflected design, development, and implementation of AI systems and technologies and its resultant data. Currently, the prevalence of digital ageism and the sources of AI bias are unknown. A scoping review informed by the Arksey and O’Malley methodology was undertaken to explore age-related bias in AI systems, identify how AI systems encode, produce, or reinforce age-related bias, what is known about digital ageism, and the social, ethical and legal implications of age-related bias. A comprehensive search strategy that included five electronic bases and grey literature sources including legal sources was conducted. A framework of machine learning biases spanning from data to user by Mehrabi et al. is used to present the findings (Mehrabi et al. 2021). The academic search resulted in 7595 articles that were screened according to the inclusion criteria, of which 307 were included for full-text screening, and 49 were included in this review. The grey literature search resulted in 2639 documents screened, of which 235 were included for full text screening, and 25 were found to be relevant to the research questions pertaining to age and AI. As a result, a total of 74 documents were included in this review. The results show that the most common AI applications that intersected with age were age recognition and facial recognition systems. The most frequent machine learning algorithms used were convolutional neural networks and support vector machines. Bias was most frequently introduced in the early ‘data to algorithm’ phase in machine learning and the ‘algorithm to user’ phase specifically with representation bias (n = 33) and evaluation bias (n = 29), respectively (Mehrabi et al. 2021). The review concludes with a discussion of the ethical implications for the field of AI and recommendations for future research.
Effect of Mn concentration on the polar optical phonons frequencies in Cd1−
xMnxTe thin films
Authors: Soares T. C. , Rodrigues Leonarde N. , Moura L. G. , Ferreira S. O. , Mello S. L. A. , Sciammarella P. V. , Massardi G. T. , Araujo E. N. D.
Published: August 2023

Cd1−xMnxTe (CMT) is a wide bandgap semiconductor that stands out among the ternary compounds in several industrial applications, such as optoelectronic and solar cell devices. Therefore, it is worth understanding the mechanisms of light interaction with CMT produced by growth techniques. In this work, we investigate the room temperature Raman scattering by longitudinal optical phonon modes CdTe-like (LO1) and MnTe-like (LO2) in CMT thin films grown on Si(111) by molecular-beam epitaxy. The well-known linear dependence of LO1 and LO2 frequencies on x is observed in Raman spectra when the excitation photon energy is above the bandgap energy. As expected, for the excitation energy of the incident laser line near the fundamental gap of CMT, the resonance becomes evident in the Raman results. However, for a specific resonance condition due to tuning of the bandgap energy dependence on Mn concentration, the frequencies of the LO1 and LO2 phonon modes remain constant as the average manganese concentration increases to values x≳ 0.30. From micro-photoluminescence spectroscopy investigations, we concluded that for Mn concentration above 0.3, a broad range of optical transitions provides the required conditions for a resonant Raman scattering selected by the incident photon energy. It introduces a resonant selectivity of regions where the incident excitation energy coincides with a bandgap energy associated with a specific value of x, even for samples with nominally different compositions. The results show the sensitivity of resonant Raman to express diagnostics of ternary compound growth.
Time-resolved pump–probe spectroscopic ellipsometry of cubic GaN. I. Determination of the dielectric function
Authors: Baron Elias , Goldhahn Rüdiger , Espinoza Shirly , Zahradník Martin , Rebarz Mateusz , Andreasson Jakob , Deppe Michael , As Donat J. , Feneberg Martin
Published: August 2023

An ultra-fast change of the absorption onset for zincblende gallium-nitride (zb-GaN) (fundamental bandgap: 3.23 eV) is observed by investigating the imaginary part of the dielectric function using time-dependent femtosecond pump–probe spectroscopic ellipsometry between 2.9 and 3.7 eV. The 266 nm (4.66 eV) pump pulses induce a large electron–hole pair concentration up to 4×1020cm−3, which shift the transition energy between conduction and valence bands due to many-body effects up to ≈500 meV. Here, the absorption onset increases due to band filling while the bandgap renormalization at the same time decreases the bandgap. Additionally, the absorption of the pump-beam creates a free-carrier profile within the 605 nm zb-GaN layer with high free-carrier concentrations at the surface, and low concentrations at the interface to the substrate. This leads to varying optical properties from the sample surface (high transition energy) to substrate (low transition energy), which are taken into account by grading analysis for an accurate description of the experimental data. For this, a model describing the time- and position-dependent free-carrier concentration is formulated by considering the relaxation, recombination, and diffusion of those carriers. We provide a quantitative analysis of optical experimental data (ellipsometric angles Ψ and Δ) as well as a plot for the time-dependent change of the imaginary part of the dielectric function.