bluuebunny/crossref_metadata_2025 huggingface dataset:
The Potential of Exercise on Lifestyle and Skin Function: Narrative Review
Authors: Oizumi Ryosuke , Sugimoto Yoshie , Aibara Hiromi
Published: February 2024

Background

The skin is an important organ of the human body and has moisturizing and barrier functions. Factors such as sunlight and lifestyle significantly affect these skin functions, with sunlight being extremely damaging. The effects of lifestyle habits such as smoking, diet, and sleep have been studied extensively. It has been found that smoking increases the risk of wrinkles, while excessive fat and sugar intake leads to skin aging. Lack of sleep and stress are also dangerous for the skin’s barrier function. In recent years, the impact of exercise habits on skin function has been a focus of study. Regular exercise is associated with increased blood flow to the skin, elevated skin temperature, and improved skin moisture. Furthermore, it has been shown to improve skin structure and rejuvenate its appearance, possibly through promoting mitochondrial biosynthesis and affecting hormone secretion. Further research is needed to understand the effects of different amounts and content of exercise on the skin.

Objective

This study aims to briefly summarize the relationship between lifestyle and skin function and the mechanisms that have been elucidated so far and introduce the expected effects of exercise on skin function.

Methods

We conducted a review of the literature using PubMed and Google Scholar repositories for relevant literature published between 2000 and 2022 with the following keywords: exercise, skin, and life habits.

Results

Exercise augments the total spectrum power density of cutaneous blood perfusion by a factor of approximately 8, and vasodilation demonstrates an enhancement of approximately 1.5-fold. Regular exercise can also mitigate age-related skin changes by promoting mitochondrial biosynthesis. However, not all exercise impacts are positive; for instance, swimming in chlorinated pools may harm the skin barrier function. Hence, the exercise environment should be considered for its potential effects on the skin.

Conclusions

This review demonstrates that exercise can potentially enhance skin function retention.
Carbon Stock Estimation From Vegetation Biomass Using Spot-7 Imagery
Authors: Rahmatika Iklila , Hidayati Iswari Nur , Suharyadi R , Nurjani Emilya
Published: February 2024

Vegetation absorbs carbon dioxide (CO2 ) emissions during photosynthesis. Covering more areas with trees will increase the CO2 absorption capacity more substantially than other vegetation like bushes, grasses, or rice fields. Trees convert the CO2 captured during photosynthesis into organic carbon to be stored in biomass. Woody trees account for approximately 60% of the total aboveground tree biomass, and trunks, where food reserves produced in photosynthesis are stored, have relatively large biomass compared to other parts of the tree. The biomass of a vegetation stand determines the optimization of air pollutant absorption in urban areas. Yogyakarta City is the center for tourism, education, and cultural activities in Indonesia, which is vulnerable to land-use conversion, a factor of the shrinking green space. This study aimed to estimate carbon stock from vegetation biomass in Yogyakarta City using the remote sensing product SPOT-7 imagery. To calculate the vegetation biomass, the diameter at breast height (DBH) of stands was measured in the field. Then, statistical analyses were performed to determine the correlation and regression between the actual or observed biomass and the Normalized Difference Vegetation Index (NDVI) value derived from the SPOT-7 image. The regression model used was y = 1.4277x – 0.0849. The total biomass produced in Yogyakarta City was estimated at 1,399,487.1 tonnes, which contained 643,764.1 tonnes of carbon stock.
The Regionalism of Borders in Indonesia (Case Study: Sebatik Island, Indonesia)
Authors: Nugroho Agung Satriyo , Rijanta R , Santoso Purwo , Marfai Muh Aris
Published: February 2024

Border  management  has,  on  the  one  hand,  grown  beyond  the  conceptual  limit  that  is  the terminological deﬁnition of borders as lines separating countries to also factor in their development as areas. On the other, it should aim to strengthen state sovereignty and improve the welfare of its citizens. Tese ofen lead to the dichotomy between security and prosperity in border management approaches. Regionalism is an approach used to create regional integration across national borders, but this concept is strongly inﬂuenced by  the  interests  of  states  on  each  side  of  the  border.  Terefore,  this  research  explores  if  spatial  interaction between border communities is controlled by the regionalism concept introduced by the state or, instead, grows organically  as  part  of  regionalization  due  to  livelihoods  that  require  border  crossings.  It  used  a  case  study of Sebatik Island in the Indonesia-Malaysia border area. Te qualitative research design applied exploratory principles on the spatial interaction pattern formed between border communities and then synthesized the identiﬁed  units  of  information  on  transboundary  activities  while  considering  government-issued  policies on border management. Results showed that regionalism was only minimally implemented in managing the border  area.  It  means  that  border  landscapes  in  Indonesia  are  organically  formed  on  the  micro-scale  even though the perspective of regionalism has long been adopted at the regional level, i.e., ASEAN.
Temporal Assessment of the Effect of Flooding Vulnerability on Agricultural Land Use in the Gambia
Authors: Ibol Philip Mopnang
Published: February 2024

Flooding is a significant environmental problem, projected to intensify from 2010 to 2030. This natural disaster has affected several regions globally, leading to loss of life and property, community disruption, economic loss, injuries, and deaths. Factors contributing to flooding include heavy rainfall, rising sea levels, lowlands, waterways, climatic variations, wetlands, soil types, and unplanned urban settlements. The most severe case in the history of the Gambia struck in 2022. Therefore, this study aimed to identify areas vulnerable to flooding and the effect on agricultural land in the Gambia, as well as suggest preventive measures. The method adopted included the collection of secondary data from Landsat ETM imagery, Digital Elevation Model, rainfall data, Copernicus Global Land Services (CGLS), and Food Agricultural Organisation soil maps. The satellite imageries were processed and classified using ArcGIS 10.7.1, generating land use and land cover, slope, drainage density, rainfall, and soil maps. ArcGIS, combined with the Analytic Hierarchy Process (AHP), was used to integrate these maps to produce a vulnerability map for the study. The results showed areas with very high, high, moderate, low, and very low vulnerability. Based on the classification, coastal and lowland regions were in the high category. Therefore, this study recommended the construction of water barricades in vulnerable coastal areas to mitigate the disaster.
Human Capital and Regional Economic Growth in Indonesia: A Spatial Analysis Approach
Authors: Windhani Kikin , Purwaningsih Yunastiti , Mulyaningsih Tri , Samudro Bhimo Rizky , Hardoyono Fajar
Published: February 2024

Endogenous growth theory assumes that human capital is a prominent factor in regional economic growth. However, the imbalance of human capital between regions is still a major problem in economic growth in Indonesia. Previous studies on regional economic growth have recognized the importance of considering spatial aspects as a determinant of regional economic growth. The geographical area in the form of an archipelago with a large number of administrative districts and cities produces pros and cons regarding the influence of spatial aspects on the regional growth of urban districts. This study aims to analyze the distribution of human capital using the Alternative Human Development Index (AHDI) approach and the effect of human capital and spatial aspects on the regional economic growth of urban districts in Indonesia within the framework of endogenous growth theory. The research method uses geometric mean to measure the Alternative Human Development Index, Geographic Information System (GIS) to see the distribution of human capital and regional economic growth in Indonesia, and the spatial regression Spatial Autoregressive Moving Average (SARMA) used to analyze the spatial aspects of human capital and regional economic growth in Indonesia. The results show that human capital in Indonesia is still unequal between the western and eastern parts of Indonesia. Human capital and spatial factors have positive effects and are the most influential determinants of Indonesia's regional economic growth, as indicated by the value of the spatial lag weight matrix of the dependent variable (ρ) and the spatial error term (λ) that is positive.
FAKTOR YANG MEMENGARUHI MORTALITAS PASIEN RAWAT INAP DI RUMAH SAKIT AKADEMIK UGM
Authors: Raharni Diasa Ayu , Djasri Hanevi , Ratmasari Dewi
Published: February 2024

Background: Hospital mortality indicators are an important element of a hospital patient safety monitoring program. In 2022, the record of inpatient performance at Academic Hospital UGM (RSA UGM) shows that the Net Death Rate (NDR) value has not yet reached the ideal standard, namely 34.1‰.

Objective: Identifying factors that influence the mortality rate of adult patients ≥48 hours in inpatient care and developing a program plan to reduce hospital mortality at RSA UGM.

Methods: An explanatory sequential design of mixed methods research was used. The medical records of adult patients admitted to RSA UGM from October 2022 to December 2022. Quantitative data analysis used chi-square, Fisher’s exact tests, and multivariate logistic regression. Qualitative data was obtained from focus group discussions with three separate groups, namely the managerial group, the doctor team, and the nurse team., while qualitative data used thematic analysis.

Results: 388 subjects were obtained with 18 (4.64% or 46.4‰) patients who died during treatment ≥48 hours. Independently, ward type (OR 10,799, CI 95 % 3,990 – 29,233), EWS score (OR 15,644, CI 95 % 5,511 – 44,412), and some comorbidities (OR 8,603, CI 95 % 2,769 – 26,730) associated with ≥48 hours in-hospital mortality (<0.001). Multivariate analysis showed that ward type (p=0.018, aOR 4,122, CI 95 % 1,279 – 13,284) and Early Warning System (EWS) score (p=0.016, aOR 4,531, CI 95 % 1,327 – 15,469) had a strong association with ≥48 hours in-hospital mortality. The proposed program to reduce hospital mortality rates by increasing ICU capacity, improving the competency and skills of ICU nurses, adding intensivists, controlling nosocomial infections in ICU, increasing understanding regarding EWS for ward nurses, improving the EWS monitoring, and improving the competency of ward nurses in emergencies condition.

Conclusion: The EWS score >5 and intensive care are significantly related to in-hospital mortality ≥48 hours after hospitalization so management needs to improve the quality of services at the RSA UGM by carrying out a strategy to reduce hospital mortality rates to decrease the net mortality rate in accordance with the Ministry of Health’s national standards.
Harnessing Asset-Backed Securities to Solve the Financing Problem of China’s Sports Venues: AHP Risk Analysis Methodology and Empirical Study
Authors: Li Xinyang , Wang Zhiyuan
Published: February 2024

Financing sports stadiums in China is challenging due to government fiscal pressure, market competition, and risk management. This study explores an innovative financing model - Asset-Backed Securities (ABS) - and evaluates its risk factors using the Analytic Hierarchy Process (AHP). The AHP method decomposes the problem into goal, criterion, and indicator layers, constructs judgment matrices by pairwise comparisons, and calculates the weight vectors of each factor, thus obtaining the relative importance of each risk factor for ABS financing. The results indicate that cash flow instability, tax policy, and credit rating are the most important factors in operational risk, policy risk, and financing risk, respectively. This study suggests that ABS financing provides an effective and flexible financing method for China’s sports stadiums, which can alleviate the government’s fiscal burden, enhance the operational capacity of the venues, and promote sustainable development.
Los mamíferos grandes y medianos en la Bahía de Chismuyo Honduras. Una alerta para su conservación: ¿qué nos indican los modelos de ocupación y detección?
Authors: Portillo-Reyes Héctor Orlando , Elvir Fausto , Mejía David , Berrocal Milena
Published: February 2024

Durante los meses de enero y febrero del año 2018, se realizó un estudio usando trampas cámara en el ecosistema de mangle y bosque seco tropical, en la Bahía de Chismuyo, Honduras. A partir de los datos obtenidos se estimaron las probabilidades de ocupación y detección de los mamíferos grandes y medianos, a lo largo de la Bahía de Chismuyo. El total del esfuerzo de muestreo fue de 630 noches cámara, con un registro de 10 especies de mamíferos siendo estos: Herpailurus yagouaroundi, Canis latrans, Tamandua mexicana, Procyon lotor, Didelphis virginiana, Spilogale angustifrons, Sylvilagus floridanus, Odocoileus virginianus, Didelphis marsupialis y Mephitis macroura. Los análisis indican una ocupación (Ψ) y detección (p) baja para cada una de las especies registradas en La Bahía de Chismuyo. Las poblaciones de mamíferos grandes y medianos se encuentran en situación crítica de conservación, y es urgente tomar medidas para su protección de manera inmediata. Se debe de establecer un monitoreo sistemático que permita tener una mejor perspectiva de las tendencias de las poblaciones de mamíferos grandes y medianos en la Bahía de Chismuyo.
Image Captioning: A Comprehensive Review
Authors: Mishra Yash Vardhan
Published: February 2024

Abstract: The Image Caption Generator is an intriguing project that bridges the domains of computer vision and natural language processing, aiming to automatically generate descriptive text for images. In the last decade, considerable progress has been made, yet key challenges in optimising Convolutional Neural Networks (CNNs) for precise image feature extraction and refining Long Short-Term Memory (LSTM) networks for coherent text generation persist. Challenges include overfitting, limited context understanding, and difficulties in modelling long-range dependencies. Solutions have emerged in the form of attention mechanisms, which help focus on relevant image regions, and advanced LSTM architectures like the use of Gated Recurrent Units (GRUs) to improve sequential modelling. These innovations have significantly enhanced the overall performance, leading to more accurate and contextually relevant image captions, ultimately advancing the synergy between computer vision and natural language processing in the realm of image captioning
Coletânea de saberes e experiências da Escola do Aprender
Authors: Passoello Germano
Published: February 2024

O Projeto Escola do Aprender, foi uma das iniciativas que participaram do Edital Educar para Transformar do Instituto MRV, selecionada dentre as 10 propostas mais inovadoras no cenário nacional, desenvolveu-se nos anos de 2020 e 2021. Tendo como principal enfoque atuar em escolas públicas e contextos de educação não formal, o projeto oportunizou impulsos para a autoeducação de 150 professores em 49 escolas do Rio Grande do Sul, com estimativa de mais de 4000 mil estudantes impactados por essa primeira edição. Reunindo pensadores, professores e diversos outros profissionais dedicados à promoção humana, a presente coletânea registra os pensamentos, as concepções e fundamentos que orientaram esse trabalho.
Caso de curso letal de mutación homocigota del gen nuclear mitocondrial hidroxiisobutiril-CoA hidrolasa HIBCH
Authors: Fernández Cruz Laura Ximena , Ortiz Giraldo Blair
Published: February 2024

Introducción: el síndrome de Leigh (SL) es una enfermedad neurodegenerativa infrecuente que afecta principalmente a lactantes y a escolares, ocasionada por una mutación en genes involucrados en la vía de la fosforilación oxidativa y cuyo déficit produce una disfunción en el metabolismo energético mitocondrial. Clínicamente, se caracteriza por un rápido deterioro neurológico, hallazgos típicos en neuroimagen y marcadores bioquímicos que orientan en su reconocimiento. En la mayoría de los pacientes tiene un curso progresivo y mortalidad temprana.
Presentación del caso: se presenta el caso de una lactante de 5 meses que presenta perdida de los hitos del desarrollo. Los paraclínicos mostraron lactoacidosis, en neuroimagen necrosis nucleobasal, y la secuenciación genómica completa puso en evidencia una mutación homocigota del gen nuclear mitocondrial de la enzima 3-hidroxiisobutiril-CoA hidrolasa HIBCH. La paciente evolucionó con epilepsia refractaria, movimientos anormales, síndrome de West, apneas y falleció a los 10 meses de vida por insuficiencia respiratoria aguda.
Discusión: el SL es con frecuencia una enfermedad rápidamente progresiva, que puede ser causada por errores innatos del metabolismo como la mutación del gen de la enzima HIBCH. El diagnóstico confirmatorio se hace con secuenciación exómica o genómica masiva y su manejo consiste en el tratamiento de los síntomas, modificaciones nutricionales, cuidado paliativo y consejería genético-reproductiva.
Conclusión: el SL por mutaciones en el gen HIBCH es una enfermedad neurodegenerativa con síntomas variables, que afecta el desarrollo motor e intelectual. El diagnóstico se basa en biología molecular. El tratamiento actual busca aliviar síntomas y ajustar la nutrición, evidenciando desafíos inherentes a errores innatos del metabolismo.
Classificação de Regimes Políticos na América Latina: um estudo comparado das principais plataformas de mensuração
Authors: Pereira da Nóbrega Júnior José Maria
Published: February 2024

Na América Latina, a maioria dos países apresenta classificação intermediária em relação a qualidade de suas democracias. A pesquisa apresentou uma forma inovadora de análise comparativa de regimes políticos na América Latina. Seguindo estudos pioneiros, nossa inovação é metodológica. Nosso objetivo central foi, a partir da construção de um conceito objetivo de democracia, traçar uma forma padronizada de comparação entre os regimes da região. Para isso, adotamos o método quantitativo de análise de dados estatísticos resgatados dos principais institutos de pesquisa de mensuração de regimes políticos, estes: a The Economist Intelligence Unit (Democracy Index), o Varieties of Democracy Institute (V-DEM), e a Freedom House. A pesquisa resultou numa escala tricotômica (democracia, semidemocracia ou autoritarismo) dos regimes analisados, com a uniformização dos dados nas médias estatísticas das três plataformas de análise dos dados nos três institutos, na qual foram destacados os países em suas qualidades democráticas. Houve alta correlação entre os resultados, com destaque para a maior correlação entre os institutos do Democracy Index e da Freedom House como sendo mais associados e o V-DEM como mais criterioso nas análises dos países. Sendo assim, Uruguai, Costa Rica e Chile foram apontados como os mais democráticos. A maioria dos países se situa numa zona intermediária, ou cinzenta, entre um regime e outro (semidemocráticos ou semiautoritários). E Cuba, Venezuela e Haiti como os regimes menos democráticos, ou mesmo autoritários.
O surgimento de novos partidos políticos modernos na África: uma análise sobre o sistema político partidário da Guiné-Bissau
Authors: Pereira Fela Armando
Published: February 2024

Historicamente, a Guiné-Bissau é um pequeno Estado da África Ocidental que depende de ajuda externa para garantir a sobrevivência. A situação política da Guiné-Bissau tem sido assinalada pela instabilidade política e governativa após a independência desse país. Dessa forma, este artigo visa analisar quais são os fatores que contribuíram para o surgimento de novos partidos políticos modernos na Guiné-Bissau de 1994 a 2014. Para isso, foi utilizado o método de estudo de caso sobre a experiência da Guiné-Bissau e de uma análise qualitativa. Assim, esta pesquisa concluiu que a Guiné-Bissau precisa fazer uma verdadeira reforma no sistema partidário, com a finalidade de promover o surgimento e a consolidação das agremiações partidárias organizadas e fortemente institucionalizados, as quais são financiadas por meio de um mecanismo transparente e capaz de capacitar suas lideranças para funções políticas. Além disso, é fundamental estabelecer um mecanismo normativo possibilitando que os fundos partidários sejam distribuídos somente aos partidos que conseguissem uma determinada porcentagem de votos, como forma de conseguir a maior participação política dos eleitorados na tomada de decisão dos partidos políticos e reduzir o altíssimo índice de fragmentação no sistema partidário guineense. Isso possibilitará a maior competividade entre os partidos políticos garantirá a maior qualidade de democracia no país.
Seria o Bolsonarismo a Expressão Brasileira do Neofascismo?
Authors: Silva Andrada Leonardo
Published: February 2024

Resenha do livro "Neofascismo, Autocracia e Bonapartismo no Brasil", organizado por Milton Pinheiro, Luiz Bernardo Pericás e Antonio Carlos Mazzeo.
O direito antidiscriminatório: a questão da orientação sexual
Authors: Moraes da Costa Marli Marlene , Ferreira Costa Thalles
Published: February 2024

O presente artigo cinge-se à análise do Direito Antidiscriminatório no que toca à repressão penal dos casos de homofobia. Orienta-se por pesquisa bibliográfica e jurisprudencial. Justifica-se tendo em vista o número crescente de violências perpetradas contra gays, lésbicas, travestis e transexuais. Percebe-se uma tendência omissa no que toca à subsunção das condutas na lei de racismo. É que os operadores do direito, à revelia da jurisprudência do Supremo Tribunal Federal, insistem em classificar as condutas racistas no crime de injúria racial, desconsiderando, portanto, a decisão do órgão constitucional. Deste modo, necessário esquadrinhar as razões da decisão, bem assim o seu alcance ante a persistente omissão do Poder Legislativo e, sobretudo, ante a crescente onda de violência que assola esse grupo vulnerável.
Ser residente
Authors: Paschkes Ronis Matías
Published: February 2024

El presente artículo se basa en una investigación que tuvo como objetivo indagar y explorar acerca de la experiencia de habitar en una residencia geriátrica pública gestionada por el Gobierno de la Ciudad de Buenos Aires. Si generalmente estas instituciones fueron estudiadas como ámbitos de soledad y pasividad en los cuales se confina a las personas de edad que ya no pueden valerse por sí mismas y están en su última etapa vital, este trabajo plantea el desafío de abordarlas como un mundo de vida.

   El abordaje de la investigación se llevó a cabo desde una metodología etnográfica. A partir de un trabajo de campo realizado entre los años 2016 y 2018, se pudieron explorar los modos en que los residentes experimentan la vejez y el habitar la institución. La labor etnográfica me condujo a desarrollar una perspectiva que denominé “gerontología de la experiencia”, desde la cual he buscado aprender y reflexionar sobre la vejez más allá de la edad, para pasar a considerarla como una vivencia específica y situada.
"É nós ou é a gente, só não pode ser eles": moralidades, proximidades e conexões sobre o funk de milícia
Authors: Borges da Silva Gabriel
Published: February 2024

A partir deste artigo pretendo abrir em meus estudos olhares sobre processos de curtição, via a contextualização do funk enquanto um movimento cultural.  Pois, percebi que a circulação das letras de funk e a forma como elas são consumidas podem servir para refletir a respeito de questões que se referem aos acessos e possibilidades de se viver na cidade. Neste sentido, foram reunidas, a partir de trabalho desenvolvido em grupo, diversas letras do que estava sendo chamado em redes sociais de funk de milícia, como uma vertente do funk carioca. A partir dos comentários e notícias em aplicativos que relatavam acontecidos a respeito da expansão da milícia na Zona Oeste do Rio de Janeiro, como foco no período entre 2020 e 2022. A partir desse material, busquei refletir como processos de curtição produzem ou refletem desigualdades em relação a cidade e bem como, em determinados ambientes, a respeito de quem pode e como se pode curtir, morrer e matar. Afinal, as letras de funk abordadas servem como demarcações, explanações e explicitações de relações de poder, afeto, conquistas e negócios estabelecidos a partir do crescimento da milícia no Rio de Janeiro.
Modelo de Inovação via P&D própria para Organizações de Serviços Públicos
Authors: Corrêa Neves Maria Lúcia , Prim Márcia Aparecida , Dandolini Gertrudes Aparecida , De Souza João Artur , da Silva Solange Maria
Published: February 2024

Este artigo apresenta um modelo delineado para orientar as Organizações de Serviços Públicos a explorar os benefícios da inovação, que é derivada da adoção de atividade de P&D (Pesquisa e Desenvolvimento) própria. O modelo foi delineado levando em consideração o novo pensamento sobre a necessidade de transformar radicalmente as organizações que prestam serviços públicos, adotando práticas de inovação mais sistêmicas e intensificando o uso de P&D para abordar desafios ou missões sociais. A metodologia utilizada para delinear o modelo foi predominantemente qualitativa, pautada pelo método indutivo de análise. No estágio inicial da pesquisa, foi utilizado o procedimento técnico da pesquisa bibliográfica nas duas áreas de conhecimento relacionadas ao objetivo da pesquisa: inovação no setor público e inovação via P&D. O modelo é resultado da combinação de conhecimentos advindos da literatura e da cocriação entre pesquisadores acadêmicos e pesquisadores corporativos da área de Segurança Pública brasileira. O modelo, denominado “Modelo de Inovação via P&D própria para Organizações de Serviços Públicos” é composto de até quatro etapas não lineares e de elementos agregadores. As etapas são: estratégia, P&D, implementação e avaliação. Os elementos agregadores são: criação de valor público, feedback, aprendizagem contínua, ambiente de uso e a Sociedade, que é representada no modelo em função da presença do conceito inovação aberta.
A note on the Vukotic-Gordon mini-earths
Authors: Cirkovic Milan
Published: February 2024

A recent proposal for a new kind of astroengineering artifact due to Vukotic
and Gordon (2022) is discussed, in particular in light of multiple benefits
offered by the magnetic Penrose process. It is argued that constructing a
large number of artifacts of this kind is sufficiently strongly motivated
for any advanced extraterrestrial society that their statistical weight in
the set of all technosignatures will be significant. This will, in turn,
have important consequences for our practical SETI/search for
technosignatures projects.
Editorial
Authors: Vucevic Dragana
Published: February 2024

nema
Acetyllevocarnitine Hydrochloride for the Treatment of Diabetic Peripheral Neuropathy: A Phase 3 Randomized Clinical Trial in China
Authors: Guo Lixin , Pan Qi , Cheng Zhifeng , Li Zhiyong , Jiang Hongwei , Zhang Fang , Li Yufeng , Qiu Wei , Lu Song , Tian Junhang , Fu Yanqin , Li Fangqiong , Li Danqing
Published: February 2024

Diabetic peripheral neuropathy (DPN) is a highly prevalent chronic complication in type 2 diabetes (T2D) for which no effective treatment is available. In this multicenter, randomized, double-blind, placebo-controlled phase 3 clinical trial in China, patients with T2D with DPN received acetyllevocarnitine hydrochloride (ALC; 1,500 mg/day; n = 231) or placebo (n = 227) for 24 weeks, during which antidiabetic therapy was maintained. A significantly greater reduction in modified Toronto clinical neuropathy score (mTCNS) as the primary end point occurred in the ALC group (−6.9 ± 5.3 points) compared with the placebo group (−4.7 ± 5.2 points; P < 0.001). Effect sizes (ALC 1.31 and placebo 0.85) represented a 0.65-fold improvement in ALC treatment efficacy. The mTCNS values for pain did not differ significantly between the two groups (P = 0.066), whereas the remaining 10 components of mTCNS showed significant improvement in the ALC group compared with the placebo group (P < 0.05 for all). Overall results of electrophysiological measurements were inconclusive, with significant improvement in individual measurements limited primarily to the ulnar and median nerves. Incidence of treatment-emergent adverse events was 51.2% in the ALC group, among which urinary tract infection (5.9%) and hyperlipidemia (7.9%) were most frequent.

Article Highlights
Adipocyte-Specific Hnrnpa1 Knockout Aggravates Obesity-Induced Metabolic Dysfunction via Upregulation of CCL2
Authors: Li Xiaoya , Su Yingying , Xu Yiting , Hu Tingting , Lu Xuhong , Sun Jingjing , Li Wenfei , Zhou Jian , Ma Xiaojing , Yang Ying , Bao Yuqian
Published: February 2024

Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) is involved in lipid and glucose metabolism via mRNA processing. However, whether and how HNRNPA1 alters adipocyte function in obesity remain obscure. Here, we found that the obese state downregulated HNRNPA1 expression in white adipose tissue (WAT). The depletion of adipocyte HNRNPA1 promoted markedly increased macrophage infiltration and expression of proinflammatory and fibrosis genes in WAT of obese mice, eventually leading to exacerbated insulin sensitivity, glucose tolerance, and hepatic steatosis. Mechanistically, HNRNPA1 interacted with Ccl2 and regulated its mRNA stability. Intraperitoneal injection of CCL2-CCR2 signaling antagonist improved adipose tissue inflammation and systemic glucose homeostasis. Furthermore, HNRNPA1 expression in human WAT was negatively correlated with BMI, fat percentage, and subcutaneous fat area. Among individuals with 1-year metabolic surgery follow-up, HNRNPA1 expression was positively related to percentage of total weight loss. These findings identify adipocyte HNRNPA1 as a link between adipose tissue inflammation and systemic metabolic homeostasis, which might be a promising therapeutic target for obesity-related disorders.

Article Highlights
Brown Sequard Syndrome: Understanding the Complexities of Spinal Cord Injury
Authors: V* Gami
Published: February 2024

Brown-Sequard Syndrome (BSS) is a rare spinal cord injury characterized by asymmetrical motor and sensory dysfunction. Trauma to the spinal cord, particularly the hemi section, is the primary cause. Diagnosis involves a thorough medical history, physical examination, and imaging studies. Treatment focuses on stabilization, rehabilitation, and potential emerging therapies. This article provides a comprehensive overview of BSS, including its causes, symptoms, diagnosis, and treatment.
Numerical modeling of surface subsidence due to compaction of soil with fine inclusions
Authors:   National University of Water and Environmental Engineering, Martyniuk P. M. , Michuta O. R. ,   National University of Water and Environmental Engineering, Ulianchuk-Martyniuk O. V. ,   National University of Water and Environmental Engineering
Published: February 2024

A mathematical model of filtration consolidation of an inhomogeneous soil mass was formed taking into account the change in the size of the area during the compaction process. The inhomogeneity is considered as the presence of fine inclusions (geobarriers) the physical and mechanical characteristics of which differ from those of the main soil. From a mathematical viewpoint, the model is described by a one-phase Stefan problem that has a kinematic boundary condition on the upper moving boundary as its component. The purpose of the research is to find out the effect of fine inclusion on the dynamics of subsidence of the soil surface in the process of compaction. The change in the dimensions of the solution area is physically determined by the change in the volume of the pores of the porous medium in the process of dissipating excess pressure. If the permeability of the geobarrier is low, it affects the dynamics of consolidation processes and, accordingly, the magnitude of subsidence. Finite element solutions of the initial-boundary value problem for the nonlinear parabolic equation in the heterogeneous region with the conjugation condition of non-ideal contact were found. Numerical time discretization methods, a method for determining the change in the position of the upper boundary at discrete moments of time, and an algorithm for determining the physical and mechanical characteristics of a porous medium depending on the degree of consolidation are given. A number of test examples were considered, and the effect of a thin inclusion on the dynamics of the change in the position of the upper boundary of the problem solution area was investigated.
An effective approach in robustness optimization for solving the RFID network planning problem with uncertainty
Authors:   LMSA Lab, FSR, Mohammed V University in Rabat, Ait Lhadj Lamin S. , Raghib A. ,   LMSA Lab, FSR, Mohammed V University in Rabat, Abou El Majd B. ,   LMSA Lab, FSR, Mohammed V University in Rabat; Faculty of Sciences and Technology, University of Lille
Published: February 2024

RFID technology enables remote storage and retrieval of data on RFID tags, making it a versatile and efficient tool with widespread applications in various industries. This paper presents a solution to the challenge of deploying RFID readers, which has been a persistent problem in the RFID technology practical and theoretical communities. To address the deployment problem, the paper proposes a robust multi-objective approach that optimizes many requested objectives as: coverage, the number of deployed readers, and interference while taking into account uncontrollable parameters in the system. The simulation results demonstrate the robustness of the approach in solving the deployment problem and optimizing the RFID system under varying and unpredictable conditions. The proposed approach has the potential to contribute to the RFID technology industry and enable more efficient and effective RFID systems across different sectors.
Information System for Ukrainian Text Voiceover Based on Nlp and Machine Learning Methods
Authors:   Lviv Polytechnic National University, Bielousov Illia , Chyrun Lyubomyr ,   Ivan Franko National University of Lviv, Chyrun Sofia ,   Lviv Polytechnic National University, Budz Ihor ,   Lviv Polytechnic National University, Vlasenko Olha ,   Osnabrück University
Published: February 2024

During the research, an information system for voicing Ukrainian-language text was developed based on NLP and machine learning methods. The created information system is implemented in the form of a desktop application, which allows the process of voicing the Ukrainian-language text. The created system included all stages of software development: the design process, the implementation process, and the testing process. For the feasibility of creating this system, already existing software solutions on the market were analysed, their advantages and disadvantages were listed, which were subsequently taken into account to create a new system. During the system analysis of the system, a goal tree, a decision tree, and examples of context diagrams with process decomposition are given. One of the stages of the design of the economic part, where the budget that will be spent on the implementation of the system is analysed, all tax and administrative costs are calculated, development strategies are also analysed and the development strategy of the existing product with accompanying solutions and the product development strategy are selected. After that, an assessment was made for the feasibility of creating the designed system, it’s payback and profit. The object of the research is the process of the voiceover system of the Ukrainian-language text based on NLP and machine learning methods. The subject of the research is the methods and means of the Ukrainian-language text voicing system process based on NLP and machine learning methods. The purpose of the research is to create an information system for voicing Ukrainian- language text based on NLP and machine learning methods. The result of the work is a ready-to- implement information system for voicing Ukrainian-language text based on NLP and machine learning methods, an analytical review of literary and online sources related to the topic of voicing Ukrainian- language text based on NLP and machine learning methods, a systematic analysis of the research object, analysis and selection of software tools for system implementation, practical implementation of the system, economic justification of system implementation activities.
Data Set Formation Method for Checking the Quality of Learning Language Models of the Transitive Relation in the Logical Conclusion Problem Context
Authors: Berko Andriy , Zdebskyi Petro ,   Lviv Polytechnic National University, Vysotska Victoria ,   Osnabrück University
Published: February 2024

A method for data set formation has been developed to verify the ability of pre-trained models to learn transitivity dependencies. The generated data set was used to test the quality of learning the transitivity dependencies in the task of natural language inference (NLI). Testing of a data set with a size of 10,000 samples (MultiNLI) used to test the RoBerta model. It was found that this model is good at studying transitive dependencies in the task of logical inference because all samples from the formed dataset were correctly classified as belonging to the class similar, contradiction and neutral. It was also investigated that in the task of logical inference, the class similarity is more directed than contradiction and neutral. Because if the premise and hypothesis in the data set are swapped, the accuracy of the RoBerta model decreases by a factor of 2.97,1.17,1.26 for the similar (0.98→0.33) , neutral (0.90→0.77) , and contradiction (0.98→0.78) classes, respectively. The study iteration time is 0.0028 seconds, so only half of the data set requires approximately 84 hours of collection. This research is relevant because the ability of natural language models to explore such dependencies as transitivity, which is not explicitly specified in the training data set, is an important element of the model’s ability to generalize. It was found that RoBerta’s model is good at studying transitive dependencies in the logical inference task because it correctly classified belonging to the class similar, contradiction, and neutral on all samples from the generated data set.
Application of Methods of Recommendations in the Analysis of Computer Components
Authors:   Lviv Polytechnic National University, Veres Oleh , Hadzalo Oleh ,   Lviv Polytechnic National University
Published: February 2024

Today, the improvement of information and technical assistance to users through information technology is relevant. To improve the design of computers, we analyze its components and study the architecture, as well as the process of improving the functionality of a computer. We conducted an analytical review of existing software solutions for analyzing computer components. We consider models for forming a set of recommendations taking into account the wishes of the user. Given the specifics of the analysis of the problem situation, it is proposed to unite users into groups. Mixed categorical-numerical clustering was used to search for user groups. This took into account the numerical (Item ratings) and demographic properties of users, as well as the sparsity coefficient of the User-Item Matrix. His algorithm of operation of the hybrid recommendation system is described, which proposes to take into account the user's requirements when analyzing and generating component variability for a computer, a hybrid model of providing recommendations with a weighted weight factor is used. UML provides a conceptual model of the system. The recommendation system allows the user to use computer analysis of components, which will offer the best components and, most importantly, the most suitable details. If the user wants a completely new computer, he can use the assembly designer. Components will be selected for the user request, or a part of the computer will be offered. The target audience of the program is PC users of any age.
Analytical Review of Data Lakes and Perspectives of Application in the Field of Education
Authors:   Lviv Polytechnic National University, Pryshliak Аndrii , Orlov Mykola ,   Lviv Polytechnic National University
Published: February 2024

An analytical review of the development of Data Lakes and its application in various industries, as part of Big data concept solutions, was conducted. The available standard architectural solutions for the Data Lake organization are considered. Also, specialized areas that require different or additional aspects to solve the tasks, depending on the field of Data Lake use, are taken into account. For the proper organization of Data Lake, various data processing tools are used, including distributed data storage systems, semantic networks, and especially metadata. Metadata plays a huge role in recognizing the purpose of data and possible relationships between it and entities. An overview of the prospects for the use of Data Lake, in particular as context of Smart City, distance education and the education industry in general, was conducted.
Juraj Buzalka: Postsedliaci. Slovenský ľudový protest
Authors:   University of West Bohemia, Naxera Vladimír
Published: February 2024

Book review.
Exercițiul facultativ al drepturilor subiective
Authors: Balea Dumitru
Published: February 2024

Exercițiul drepturilor subiective este, cel mai adesea, abordat teoretic din perspectiva altuia: prerogativa titularului poate fi valorificată doar prin limitarea libertății altuia. De unde, necesitatea controlului prin instrumentul teoriei abuzului de drept. Practic, exercițiu dreptului este abordat preponderent din perspectiva sancțiunii judiciare a nesocotirii sale: acțiunea. Studiul de față schimbă perspectiva. În prim plan este situat titularul dreptului subiectiv, pentru a observa dacă exercițiul este facultativ sau i se impune ca obligatoriu. Deși răspunsul pare a înclina evident spre caracterul benevol al exercițiului, opțiuni legislative precum punerea în întârziere a creditorului estompează delimitarea dintre drept și obligație și dintre creditor și debitor. Vom verifica exercițiul principalelor categorii de drepturi subiective (reale, creanțe) pentru a concluziona asupra caracterului (facultativ sau obligatoriu) al exercițiului drepturilor subiective.
Sinteza modificărilor legislative operate prin Legile nr. 200/2023 şi nr.248/2023
Authors: Udroiu Mihail
Published: February 2024

Codul penal a suferit multiple modificări în vara anului 2023. În cuprinsul prezentului articol vor fi analizate doar modificările ce au vizat infracțiunile contra autorităţii, înfăptuirii justiției, ori infracţiunile de serviciu, contra siguranţei circulaţiei pe drumurile publice şi contra ordinii şi liniştii publice care, în esenţă, privesc: agravarea răspunderii penale pentru ultraj şi ultrajul judiciar; reconfigurarea elementului material al infracţiunilor de abuz în serviciu şi neglijenţă în serviciu consecutiv deciziilor Curţii Constituţionale; reformarea infracțiunilor contra siguranţei circulaţiei pe drumurile publice; agravarea răspunderii penale pentru infracţiunea de tulburare a ordinii şi liniştii publice.
“Naõ consentindo por modo algum, que os Meninos, e Meninas, [...] usem da Lingua propria das suas Naçoens, ou da chamada geral; mas unicamente da Portugueza”: povos indígenas e cultura escrita na antiga Capitania de Ilhéus
Authors: Souza Pedro Daniel dos Santos
Published: February 2024

A política de gestão das línguas na América portuguesa, expressa no Diretório dos índios, previa a proibição do uso da língua geral e das línguas próprias dos diversos grupos etnolinguísticos indígenas e, consequentemente, a adoção e o ensino da “Língua do Príncipe” nas povoações e vilas de índios. Elaborado para o Estado do Grão-Pará e Maranhão, quando o Diretório foi confirmado e estendido ao Estado do Brasil, por meio do Alvará de 17 de agosto de 1758, o tribunal especial do Conselho Ultramarino, instalado na Capitania da Bahia, estabeleceu as medidas necessárias para a execução da política indigenista do governo de D. José I (1750-1777) e, em particular, de sua política linguística. Nesse contexto, três vilas de índios foram erigidas na antiga Capitania de Ilhéus: Olivença, Barcelos e Santarém. Apoiando-se na História Social da Cultura Escrita e em fontes do Arquivo História Ultramarino (AHU), do Arquivo Público do Estado da Bahia (APEB) e da Biblioteca Nacional do Rio de Janeiro (BNJR), o presente artigo reflete sobre a atuação dos escrivães das Câmaras das referidas vilas, quanto à obrigação de ensinar a “ler, escrever e contar aos meninos”, e as reconfigurações demográfico-linguísticas desses espaços, caracterizados pelo uso da língua geral. Haja vista a “civilidade” dos povos indígenas que se pretendia alcançar, a política linguística expressa no Diretório e a sua implementação por meio da “escola para índios” configuram-se como variáveis fundamentais para uma maior compreensão sobre o avanço da língua portuguesa nas vilas de índios e suas implicações linguísticas.
Cultural Education for Sustaining Nusantara Religion Within Boti Indigenous Community
Authors: Wardany Octalyna Puspa , Makin Al , Maarif Samsul
Published: February 2024

Boti indigenous community which is in Timor Tengah Selatan district, Nusa Tenggara Timur preserves and nurtures their Nusantara religion, named Uis Neno ma Uis Pah. Boti is able to live through different eras, before West influences, the colonization era, modern, and contemporary. How can the Boti indigenous community be sustained with their religion as part of custom? Is there any certain methodology which they have implemented for the regeneration so their descendants keep preserving and nurturing their Nusantara religion?. This research article is focused to answer those two questions. The research is already implemented using ethnography method, so the researcher lived in the Boti indigenous community for 13 months from October 2, 2021 until November 1, 2022. This research used decolonization as the perspective method in order to understand Boti’s Nusantara religion as well as their customs in detail and holistic including the concept and the core, so enable to do the comprehensive analyzing using proper theories of education; education and culture theories from Ki Hajar Dewantara, the Indonesia National Education Notable; Tukan and Hasfaria’s theory about Adat (Indonesia: custom); Roem Topatimasang’s theory about school; and Mori’s theory about learning method. Boti implements the cultural education as the methodology to do the regeneration so the next generation know and preserve their Nusantara religion and customs. It teaches the understanding of the transformation in life that enables them to be open and flexible for the new influences. By the implementation of division on education; modern and cultural education; Boti indigenous community is able to sustain and nurture their Nusantara religion.
Karakteristik Aerodinamika Sudu Turbin Angin Bio-inspired Menggunakan Simulasi CFD
Authors: Wicaksono Yoga Arob , Munaji M , Santi Erika Eka
Published: February 2024

Tujuan dari penelitian ini adalah menginvestigasi karakteristik aerodinamika turbin angin bio-inspired. Bentuk sudu yang diusulkan adalah menyerupai isi buah pohon mahoni (Mahagoni s.p). Simulasi dilakukan dengan model 3D dan menganalisis gaya-gaya aerodinamika meliputi Cl dan Cd dari sudu turbin bio-inspired. Variasi yang digunakan yaitu kecepatan angin 0,1, 1, 2, dan 3 m/s. Parameter yang dihasilkan dari simulasi antara lain: Cl, Cd dan kontur aliran. Software yang digunakan untuk simulasi adalah OpenFOAM. Hasil penelitian menunjukkan bahwa sudu turbin angin bio-inspired memiliki karakteristik aerodinamika yang sama dengan airfoil. Cl rata-rata tertinggi diperoleh pada kecepatan 3 m/s. Sedangkan Cd rata-rata tertinggi diperoleh pada kecepatan 3 m/s.