bluuebunny/crossref_metadata_2025 huggingface dataset:
Endobronchial Ultrasonography with a Guide Sheath Transbronchial Biopsy for Diagnosing Peripheral Pulmonary Lesions within or near Fibrotic Lesions in Patients with Interstitial Lung Disease
Authors: Ito Takayasu , Okachi Shotaro , Kimura Tomoki , Kataoka Kensuke , Suzuki Yasuhiko , Kinoshita Fumie , Wakahara Keiko , Hashimoto Naozumi , Kondoh Yasuhiro
Published: November 2021

In patients with interstitial lung disease (ILD), the most frequent locations of lung cancer are within or near fibrotic lesions. However, the diagnostic yield for peripheral pulmonary lesions (PPLs) within or near fibrotic lesions using endobronchial ultrasonography with a guide sheath transbronchial biopsy (EBUS-GS TBB) may be unsatisfactory compared to that for PPLs distant from fibrotic lesions because of the difficulty in reaching the lesions. Our objectives were to evaluate the yield for PPLs using EBUS-GS TBB according to the proximity of PPLs to fibrotic lesions and to determine factors affecting the yield for PPLs. We retrospectively investigated 323 consecutive lesions using EBUS-GS TBB between 1 November 2014 and 31 December 2016. We identified PPLs with ILD in such lesions. PPLs with ILD were divided into PPLs within or near fibrotic lesions which met the criterion of PPLs, and of fibrotic lesions overlapping each other (PPLs-FL) and those distant from fibrotic lesions, which met the criterion of PPLs and the area of fibrotic lesion not overlapping each other (PPLs-NFL). Of the 323 lesions, 55 were included (31 PPLs-FL and 24 PPLs-NFL). The diagnostic yield for PPLs-FL was significantly lower than for PPLs-NFL (45.2% vs. 83.3%, p = 0.004). Multivariate analysis revealed that PPLs-NFL (odds ratio (OR) = 7.509) and a probe position within the lesion (OR = 4.172) were significant factors affecting diagnostic yield. Lesion’s positional relation to fibrotic lesions and the probe position were important factors affecting the successful diagnosis via EBUS-GS TBB in these patients.
Development and Validation of Prognostic Models for Oral Squamous Cell Carcinoma: A Systematic Review and Appraisal of the Literature
Authors: Russo Diana , Mariani Pierluigi , Caponio Vito Carlo Alberto , Lo Russo Lucio , Fiorillo Luca , Zhurakivska Khrystyna , Lo Muzio Lorenzo , Laino Luigi , Troiano Giuseppe
Published: November 2021

(1) Background: An accurate prediction of cancer survival is very important for counseling, treatment planning, follow-up, and postoperative risk assessment in patients with Oral Squamous Cell Carcinoma (OSCC). There has been an increased interest in the development of clinical prognostic models and nomograms which are their graphic representation. The study aimed to revise the prognostic performance of clinical-pathological prognostic models with internal validation for OSCC. (2) Methods: This systematic review was performed according to the Cochrane Handbook for Diagnostic Test Accuracy Reviews chapter on searching, the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines, and the Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS). (3) Results: Six studies evaluating overall survival in patients with OSCC were identified. All studies performed internal validation, while only four models were externally validated. (4) Conclusions: Based on the results of this systematic review, it is possible to state that it is necessary to carry out internal validation and shrinkage to correct overfitting and provide an adequate performance for optimism. Moreover, calibration, discrimination and nonlinearity of continuous predictors should always be examined. To reduce the risk of bias the study design used should be prospective and imputation techniques should always be applied to handle missing data. In addition, the complete equation of the prognostic model must be reported to allow updating, external validation in a new context and the subsequent evaluation of the impact on health outcomes and on the cost-effectiveness of care.
Maintenance Treatment of Newly Diagnosed Advanced Ovarian Cancer: Time for a Paradigm Shift?
Authors: DiSilvestro Paul , Colombo Nicoletta , Harter Philipp , González-Martín Antonio , Ray-Coquard Isabelle , Coleman Robert L.
Published: November 2021

Recent data have demonstrated substantial efficacy with poly (ADP-ribose) polymerase (PARP) inhibitors as treatment and/or maintenance therapy in patients with newly diagnosed advanced epithelial ovarian cancer (EOC). Here, we review efficacy and safety results from four recent Phase III trials in newly diagnosed EOC: SOLO1 (olaparib), PAOLA-1 (olaparib in combination with bevacizumab), PRIMA (niraparib), and VELIA (veliparib). The implications of these data for current clinical practice and areas for future research are discussed, including ongoing studies of targeted agents in the newly diagnosed setting. Data from SOLO1, PAOLA-1, PRIMA, and VELIA confirm the benefit of PARP inhibitors (olaparib, niraparib, veliparib) for women with newly diagnosed EOC. The greatest benefit was seen in patients with a BRCA1 and/or BRCA2 mutation or in the homologous recombination deficiency (HRD)-test positive subgroup. These four well-conducted studies have generated practice-changing data. However, deciding how to apply these results in clinical practice is challenging, and substantial differences in trial design impede cross-trial comparisons. Recent PARP inhibitor approvals (olaparib, niraparib) in the newly diagnosed EOC setting have provided new maintenance treatment options for a broader patient population. The results of these studies call for personalized medicine based on biomarker profile and other factors, including tolerability, cost considerations, and physician and patient preference. Important areas for future research include appropriate use of both BRCA mutation and HRD testing to inform magnitude of PARP inhibitor benefit as well as exploring further options for patients who are HRD-test negative and for those who become PARP inhibitor resistant.
hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA
Authors: Aughton Karen , Elander Nils O. , Evans Anthony , Jackson Richard , Campbell Fiona , Costello Eithne , Halloran Christopher M. , Mackey John R. , Scarfe Andrew G. , Valle Juan W. , Carter Ross , Cunningham David , Tebbutt Niall C. , Goldstein David , Shannon Jennifer , Glimelius Bengt , Hackert Thilo , Charnley Richard M. , Anthoney Alan , Lerch Markus M. , Mayerle Julia , Palmer Daniel H. , Büchler Markus W. , Ghaneh Paula , Neoptolemos John P. , Greenhalf William
Published: November 2021

Gemcitabine or 5-fluorouracil (5-FU) based treatments can be selected for pancreatic cancer. Equilibrative nucleoside transporter 1 (hENT1) predicts adjuvant gemcitabine treatment benefit over 5-FU. Cytidine deaminase (CDA), inside or outside of the cancer cell, will deaminate gemcitabine, altering transporter affinity. ESPAC-3(v2) was a pancreatic cancer trial comparing adjuvant gemcitabine and 5-FU. Tissue microarray sections underwent in situ hybridization and immunohistochemistry. Analysis of both CDA and hENT1 was possible with 277 patients. The transcript did not correlate with protein levels for either marker. High hENT1 protein was prognostic with gemcitabine; median overall survival was 26.0 v 16.8 months (p = 0.006). Low CDA transcript was prognostic regardless of arm; 24.8 v 21.2 months with gemcitabine (p = 0.02) and 26.4 v 14.6 months with 5-FU (p = 0.02). Patients with low hENT1 protein did better with 5-FU, but only if the CDA transcript was low (median survival of 5-FU v gemcitabine; 29.3 v 18.3 months, compared with 14.2 v 14.6 with high CDA). CDA mRNA is an independent prognostic biomarker. When added to hENT1 protein status, it may also provide treatment-specific predictive information and, within the frame of a personalized treatment strategy, guide to either gemcitabine or 5FU for the individual patient.
X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study
Authors: Ungerer Arthur , Staufer Theresa , Schmutzler Oliver , Körnig Christian , Rothkamm Kai , Grüner Florian
Published: November 2021

The growing field of cellular therapies in regenerative medicine and oncology calls for more refined diagnostic tools that are able to investigate and monitor the function and success of said therapies. X-ray Fluorescence Imaging (XFI) can be applied for molecular imaging with nanoparticles, such as gold nanoparticles (GNPs), which can be used in immune cell tracking. We present a Monte Carlo simulation study on the sensitivity of detection and associated radiation dose estimations in an idealized setup of XFI in human-sized objects. Our findings demonstrate the practicability of XFI in human-sized objects, as immune cell tracking with a minimum detection limit of 4.4 × 105 cells or 0.86 μg gold in a cubic volume of 1.78 mm3 can be achieved. Therefore, our results show that the current technological developments form a good basis for high sensitivity XFI.
Some Finite Difference Methods to Model Biofilm Growth and Decay: Classical and Non-Standard
Authors: Tijani Yusuf Olatunji , Appadu Appanah Rao , Aderogba Adebayo Abiodun
Published: November 2021

The study of biofilm formation is undoubtedly important due to micro-organisms forming a protected mode from the host defense mechanism, which may result in alteration in the host gene transcription and growth rate. A mathematical model of the nonlinear advection–diffusion–reaction equation has been studied for biofilm formation. In this paper, we present two novel non-standard finite difference schemes to obtain an approximate solution to the mathematical model of biofilm formation. One explicit non-standard finite difference scheme is proposed for biomass density equation and one property-conserving scheme for a coupled substrate–biomass system of equations. The nonlinear term in the mathematical model has been handled efficiently. The proposed schemes maintain dynamical consistency (positivity, boundedness, merging of colonies, biofilm annihilation), which is revealed through experimental observation. In order to verify the accuracy and effectiveness of our proposed schemes, we compare our results with those obtained from standard finite difference schemes and earlier known results in the literature. The proposed schemes (NSFD1 and NSFD2) show good performance. The NSFD2 scheme reveals that the processes of biofilm formation and nutritive substrate growth are intricately linked.
Cell Therapy: A New Section for the Transplant and Cell Therapy Community
Authors: Allan David
Published: November 2021

The new Cell Therapy section [...]
The “My Electricity” Program as One of the Ways to Reduce CO2 Emissions in Poland
Authors: Olczak Piotr , Żelazna Agnieszka , Matuszewska Dominika , Olek Małgorzata
Published: November 2021

One way to reduce CO2 emissions is to replace conventional energy sources with renewable ones. In order to encourage prosumers to invest in renewable energy, EU Member States are developing renewable energy subsidy programs. In Poland, in the years 2019–2020, the “My Electricity” program was implemented, co-financing was up to 50% of eligible costs (max PLN 5000, i.e., EUR 1111), and the total cost of the program was 251 million euro. During this period, around 400,000 prosumer installations were created in Poland, including over 220,000 prosumer PV Installations under the My Electricity program. The total power of the installation under the “My Electricity” program was 1.295 GWp with an average installation power of 5.72 kWp. It is estimated that the micro-installations will produce approx. 1.4 TWh of electricity annually. Depending on the replaced source of electricity (coal, gas, mix), in the next 30 years, it will help to avoid 26.2–42.7 million Mg of greenhouse gases calculated as carbon dioxide equivalents (CO2eq). The coefficient of subsidy expenditure from the “My Electricity” program was 194 EUR/kWp, and in the next 30 years, it will be 6.52 EUR/MWh. The investment in PV will save EUR 1550 million, which would have to be incurred for the purchase of CO2 emission permits.
Simulation of Coupled Power and Gas Systems with Hydrogen-Enriched Natural Gas
Authors: Lu Yifei , Pesch Thiemo , Benigni Andrea
Published: November 2021

Due to the increasing share of renewable energy sources in the electrical network, the focus on decarbonization has extended into other energy sectors. The gas sector is of special interest because it can offer seasonal storage capacity and additional flexibility to the electricity sector. In this paper, we present a new simulation method designed for hydrogen-enriched natural gas network simulation. It can handle different gas compositions and is thus able to accurately analyze the impact of hydrogen injections into natural gas pipelines. After describing the newly defined simulation method, we demonstrate how the simulation tool can be used to analyze a hydrogen-enriched gas pipeline network. An exemplary co-simulation of coupled power and gas networks shows that hydrogen injections are severely constrained by the gas pipeline network, highlighting the importance and necessity of considering different gas compositions in the simulation.
Monolithic Perovskite/Silicon-Heterojunction Tandem Solar Cells with Nanocrystalline Si/SiOx Tunnel Junction
Authors: Mercaldo Lucia V. , Bobeico Eugenia , De Maria Antonella , Della Noce Marco , Ferrara Manuela , La Ferrara Vera , Lancellotti Laura , Rametta Gabriella , Sannino Gennaro V. , Usatii Iurie , Delli Veneri Paola
Published: November 2021

Perovskite/silicon tandem solar cells have strong potential for high efficiency and low cost photovoltaics. In monolithic (two-terminal) configurations, one key element is the interconnection region of the two subcells, which should be designed for optimal light management and prevention of parasitic p/n junctions. We investigated monolithic perovskite/silicon-heterojunction (SHJ) tandem solar cells with a p/n nanocrystalline silicon/silicon-oxide recombination junction for improved infrared light management. This design can additionally provide for resilience to shunts and simplified cell processing. We probed modified SHJ solar cells, made from double-side polished n-type Si wafers, which included the proposed front-side p/n tunnel junction with the p-type film simultaneously functioning as selective charge transport layer for the SHJ bottom cell, trying different thicknesses for the n-type layer. Full tandem devices were then tested, by applying a planar n-i-p mixed-cation mixed-halide perovskite top cell, fabricated via low temperature solution methods to be compatible with the processed Si wafer. We demonstrate the feasibility of this tandem cell configuration over a 1 cm2 area with negligible J-V hysteresis and a VOC ~1.8 V, matching the sum of the VOC-s contributed by the two components.
Analysis of the Effects of Failure of a Gas Pipeline Caused by a Mechanical Damage
Authors: Rusin Andrzej , Stolecka-Antczak Katarzyna , Kapusta Krzysztof , Rogoziński Krzysztof , Rusin Krzysztof
Published: November 2021

Natural gas continues to be one of the basic energy sources used as fuel in the power sector, in industries and in households. The potential and attractiveness of this fuel is gaining special significance in the current energy transitions from coal-based power engineering to power generation based on renewable energy sources. Natural gas is supplied to consumers mainly through a network of pipelines, which ensures a relatively high reliability of the supply. Still, failures occur due to the corrosion of pipeline walls, material defects or human errors, which can result in uncontrolled release of gas. The released gas can trigger dangerous phenomena, such as fires and explosions. This paper presents an analysis of the causes and effects of damage to a medium-pressure pipeline caused by earthworks carried out within an area where a pipeline is located. Holes in the pipeline due to the impact of an excavator bucket are analysed. The impact of the excavator bucket may cause a rupture equal to 50% of the pipeline’s cross-sectional area. Hazard zones related to fires and explosions due to the released natural gas are presented. For the analysed pipeline with a diameter of 0.5 m and a gas pressure of 5 MPa, the range of hazard zones arising due to pipeline damage caused by an excavator bucket can reach about 200 m.
A Boosted Particle Swarm Method for Energy Efficiency Optimization of PRO Systems
Authors: Chen Yingxue , Gou Linfeng
Published: November 2021

The analytical solutions of complex dynamic PRO systems pose challenges to ensuring that maximum power can be harvested in stable, rapid, and efficient ways in response to varying operational environments. In this paper, a boosted particle swarm optimization (BPSO) method with enhanced essential coefficients is proposed to enhance the exploration and exploitation stages in the optimization process. Moreover, several state-of-the-art techniques are utilized to evaluate the proposed BPSO of scaled-up PRO systems. The competitive results revealed that the proposed method improves power density by up to 88.9% in comparison with other algorithms, proving its ability to provide superior performance with complex and computationally intensive derivative problems. The analysis and comparison of the popular and recent metaheuristic methods in this study could provide a reference for the targeted selection method for different applications.
Managing Non-Sewered Human Waste Using Thermochemical Waste Treatment Technologies: A Review
Authors: Beik Farhad , Williams Leon , Brown Tim , Wagland Stuart T.
Published: November 2021

The utilisation of micro-scale thermal treatment technologies for non-sewered applications has been emerging as a prominent route for the safe treatment and disposal of high water content hazardous feedstock. This study provides a comprehensive review of the technological concepts practiced up to date in commercial/pilot and small scales for various types of solid fuels. The respective challenges are critically described and discussed to aid in the selection of promising technology for on-site sanitary applications. Furthermore, the challenges observed with the nominated (pyrolysis) technology are discussed in detail and addressed. This study suggests rapid energy recovery from by-products primarily made up of the highest yield of syngas with a desirable calorific value. The optimum operating ranges are discussed to ensure a reliable thermal conversion of sludge materials considering the application constraints and technology drawbacks. However, further studies are needed to investigate the uncertainties regarding emissions, energy consumption and overall associated costs.
The Use of Prospect Theory for Energy Sustainable Industry 4.0
Authors: Kluczek Aldona , Żegleń Patrycja , Matušíková Daniela
Published: November 2021

Industry 4.0 challenges facilities entrepreneurs to be competitive in the market in terms of energy by rational decision making. The goal of the paper is aimed at introducing Prospect Theory (PT) in Industry 4.0 for making decisions in order to select an optimal energy technology. To reach this goal, an approach for decision making on energy investment has been developed. In this paper, the authors have also provided a new opportunity to apply the new decision making method for strengthening Industry 4.0 by addressing energy concerns based on which rational decisions have been made. The study uses a fuzzy analytical hierarchy process for weighting the evaluation sub-criteria of energy technologies and a modified PT for making decisions related to the selection of one of the investigated technologies. The results show that it is possible to implement PT in Industry 4.0 via a decision making model for energy sustainability. Decision probability was achieved using a behavioral approach akin to Cumulative Prospect Theory (CPT) for the considered technology options. More specifically, the probability has created the same threshold-based decision possibilities. The authors used the case study method based on a company located in North America which produces hardwood lumber. The company uses a heating system containing natural gas-fired boilers. This study has also contributed to the literature on energy sustainable Industry 4.0 by demonstrating a new phenomenon/paradigm for energy sustainability-based Industry 4.0 through using PT. In this context, the main motivation of writing the article has been to promote energy sustainability via complex mechanisms and systems that involve interrelated functions.
Role of Natural Gas Consumption in the Reduction of CO2 Emissions: Case of Azerbaijan
Authors: Gurbanov Sarvar
Published: November 2021

Azerbaijan signed the Paris Agreement in 2016 and committed to cut greenhouse gas (GHG) emissions by 35% in 2030. Meanwhile, natural gas has been vital component in the total energy mix of Azerbaijan economy and accounted for almost 65% of the total energy consumption. In the overall electricity mix, natural gas-fired power plants generate 93% of the country’s electricity. Since global energy consumption is responsible for 73% of human-caused greenhouse-gas emissions, and CO2 makes up more than 74% of the total, this study investigates possible mitigation effects of the natural gas consumption on CO2 emissions for Azerbaijan. Author employed several cointegration methodologies, namely Bound testing Autoregressive Distributed Lag (ARDL) approach, Fully Modified Ordinary Least Squares (FMOLS), Dynamic Ordinary Least Squares (DOLS), and Structural Time Series model (STSM). Author of this paper found that when the share of natural gas increases 1 percent in the total energy mix, CO2 emission per capita decreases approximately 0.14 percent as a result of the ARDL, FMOLS, and DOLS models. All three models provide cointegration between the share of natural gas in the total energy mix and reduction in CO2 emissions.
Contributions to Modeling, Simulation and Controlling of a Pumping System Powered by a Wind Energy Conversion System
Authors: Bordeașu Dorin , Proștean Octavian , Hatiegan Cornel
Published: November 2021

At present, the energy consumption of the pumping unit represents the highest cost in operating a pumping system. Due to this reason, this paper proposes a reliable and robust solution for integrating a wind energy conversion system (WECS) into an already existing pumping system (PS), without being overly intrusive for the PS, and without altering the control strategy or the hardware of the commercial WECS. The current work begins by presenting the modeling undertaken, which includes a WECS with pitchable blades, a doubly-fed induction generator (DFIG) together with its power converter, a centrifugal pump, an induction motor (IM) with its power converter, and an irrigation network with a pressure transducer. The second part consists of the proposed three-level controller: a general controller that regulates the WECS power demand according to the pumping pressure reference; three second-level controllers; two necessary for the WECS and one for the PS; and three first level controllers, two for controlling the power converters of the WECS generator and one for controlling the pump motor power converter. Finally, the simulation results of the proposed system control strategy are presented, showing its technical feasibility and good performance.
Testing Selected Personal Protection Items of Firefighters in Combined Conditions of Mechanical Loads and Temperatures Occurring during Gas LNG Leaks
Authors: Ogrodnik Paweł , Powęzka Aleksandra , Piec Robert , Zwęgliński Tomasz , Smolarkiewicz Marcin , Gromek Paweł , Wróbel Rafał , Węsierski Tomasz , Majder-Łopatka Małgorzata , Wąsik Wiktor
Published: November 2021

The article examined selected individual protection used during rescue and fire-extinguishing activities. Fire helmet and special shoes were examined under conditions resembling the operational conditions of LNG gases. The assessment of the equipment consumption was based on strength tests. The main threats come from thermal and mechanical factors. Therefore, firefighters must properly protect their head and legs. At −80 °C, the energy of the impact force of the beater in the headache was, 12.4 J and 15.1 J for points P1 and P2, respectively. The studies showed that cooling the chamber to −80 °C adversely affected the structure of the fire helmet exposed to impact Dynamic. Research work was carried out as part of the Research and Development project No. DOB-BIO9/15/02/2018.
Temperature Characteristics of Two Fomitiporia Fungi Determine Their Geographical Distributions in Japan
Authors: Torii Masato , Masuya Hayato , Hattori Tsutomu
Published: November 2021

Two morphologically similar fungi, Fomitiporia torreyae and Fomitiporia punctata, are causal fungi of various tree diseases in Japan and are speculated to be distributed in different climatic zones. Clarifying their distribution ranges and climatic preferences would contribute to the prediction of disease occurrences and consideration of controls. In this study, we predicted the present geographical distributions of F. torreyae and F. punctata in Japan using a Maxent species distribution model to analyze our data and previously published collection records. In addition, we examined the importance of temperature on these predictions via jackknife analysis and evaluated the effects of temperature on mycelial growth and survival to elucidate determinants of their distribution. The predicted potential distributions showed that F. torreyae is mainly distributed in warmer areas compared to F. punctata. Jackknife analysis indicated the high importance of temperature variables for each fungal prediction. The two fungi were usually found at locations within upper or lower temperature limits for the growth and survival of each species. These results suggest that temperature is a key determinant of their distributions in Japan. This is the first report to predict fungal distribution based on species distribution modeling and evaluation of fungal physiological characteristics. This study indicates that the projected global warming will influence the future ranges of the two fungal species.
Dimensional Stability of Treated Sengon Wood by Nano-Silica of Betung Bamboo Leaves
Authors: Rahayu Istie , Dirna Fitria Cita , Maddu Akhiruddin , Darmawan Wayan , Nandika Dodi , Prihatini Esti
Published: November 2021

Sengon (Falcataria moluccana Miq.) is one of the fastest growing wood that is broadly planted in Indonesia. Sengon wood has inferior wood properties, such as a low density and dimensional stability. Therefore, sengon wood requires a method to improve its wood quality through wood modification. One type of wood modification is wood impregnation. On the other hand, Betung Bamboo leaves are considered as waste. Betung Bamboo leaves contain silica. Based on several researches, nano-SiO2 could improve fast-growing wood qualities. According to its perfect solubility in water, monoethylene glycol (MEG) is used in the study. The objectives are to evaluate the impregnation treatment (MEG and nano-silica originated from betung bamboo leaves) in regard to the dimensional stability and density of 5-year-old sengon wood and to characterize the treated sengon wood. MEG, MNano-Silica 0.5%, MNano-Silica 0.75%, and MNano-Silica 1% were used as impregnation solutions. The impregnation method was started with 0.5 bar of vacuum for 60 min, followed by 2.5 bar of pressure for 120 min. The dimensional stability, density, and characterization of the samples were studied through the use of scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy, X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The results show that the treatment had a significant effect on the dimensional stability and density of sengon wood. Alterations in the morphology of treated sengon wood were observed through the full coverage of the pits on the vessel walls (SEM analysis results) and the detection of ethylene (FTIR analysis results) and silica (XRD and FTIR analysis results). Overall, the 0.75% MNano-Silica treatment was the most optimal treatment for increasing the dimensional stability and density of 5-year-old sengon wood.
An Analysis on Contemporary MAC Layer Protocols in Vehicular Networks: State-of-the-Art and Future Directions
Authors: Hota Lopamudra , Nayak Biraja Prasad , Kumar Arun , Ali G. G. Md. Nawaz , Chong Peter Han Joo
Published: November 2021

Traffic density around the globe is increasing on a day-to-day basis, resulting in more accidents, congestion, and pollution. The dynamic vehicular environment induces challenges in designing an efficient and reliable protocol for communication. Timely delivery of safety and non-safety messages is necessary for traffic congestion control and for avoiding road mishaps. For efficient resource sharing and optimized channel utilization, the media access control (MAC) protocol plays a vital role. An efficient MAC protocol design can provide fair channel access and can delay constraint safety message dissemination, improving road safety. This paper reviews the applications, characteristics, and challenges faced in the design of MAC protocols. A classification of the MAC protocol is presented based on contention mechanisms and channel access. The classification based on contention is oriented as contention-based, contention-free, and hybrid, whereas the classification based on channel access is categorized as distributed, centralized, cluster-based, cooperative, token-based, and random access. These are further sub-classified as single-channel and multi-channel, based on the type of channel resources they utilize. This paper gives an analysis of the objectives, mechanisms, advantages/disadvantages, and simulators used in specified protocols. Finally, the paper concludes with a discussion on the future scope and open challenges for improving the MAC protocol design.
Those Who Have Continuing Radiation Anxiety Show High Psychological Distress in Cases of High Post-Traumatic Stress: The Fukushima Nuclear Disaster
Authors: Orui Masatsugu , Nakayama Chihiro , Moriyama Nobuaki , Tsubokura Masaharu , Watanabe Kiyotaka , Nakayama Takeo , Sugita Minoru , Yasumura Seiji
Published: November 2021

Background: this cross-sectional study aimed to clarify the associations among media utilization, lifestyles, and the strong radiation anxiety that has persisted 9 years after the 2011 nuclear accident. Moreover, the relationships among psychological distress, post-traumatic stress, and strong radiation anxiety were examined. Methods: for the multivariate regression analysis, the independent variables were radiation anxiety at the time of the accident and the current status, categorized as “continuing/emerging strong radiation anxiety”. Media utilization (local, national, internet, and public broadcasts, and public relations information) and lifestyle variables (sleep quality, regular exercise, and drinking habits) were set as the dependent variables. Moreover, the psychological distress of residents with continuing/emerging strong radiation anxiety was examined by an analysis of covariance stratified by post-traumatic stress. Result: there was no significant association between lifestyle variables and media utilization, except for local media (OR: 0.435, 95% CI: 0.21–0.90). Conversely, significantly high psychological distress was confirmed among residents with continuing/emerging radiation anxiety. The K6 score, representing psychological distress, for those with higher post-traumatic stress was 12.63; for those with lower post-traumatic stress, it was 5.13 (p = 0.004). Conclusions: residents with continuing/emerging strong radiation anxiety showed high psychological distress, which has been strengthened by higher post-traumatic stress.
Transitional Care Management from Emergency Services to Communities: An Action Research Study
Authors: Batista José , Pinheiro Carla Munhoz , Madeira Carla , Gomes Pedro , Ferreira Óscar Ramos , Baixinho Cristina Lavareda
Published: November 2021

In recent years, nurses have developed projects in the area of hospital to community transition. The objective of the present study was to analyze the transitional care offered to elderly people after they used emergency services and were discharged to return to the community. The action research method was chosen. The participants were nurses, elderly people 70 years old or older, and their caregivers. The study was carried out from October 2018 to August 2019. The data were collected by means of semi-structured interviews with the nurses, analysis of medical records, participatory observation, phone calls to the elderly people and caregivers, and team meetings. The qualitative data were submitted to Bardin’s content analysis. Statistical treatment was carried out by applying SPSS version 23.0. The institution’s research ethics committee approved the research. Only 31.4% of the sample experienced care continuity after discharge, and the rate of readmission to emergency services during the first 30 days after discharge was 33.4%. The referral letters lacked data on information provided to patients or caregivers, and nurses mentioned difficulties in communication between care levels, as well as obstacles to teamwork; they also mentioned that the lack of health policies and clinical rules to formalize transitional care between the hospital and the community perpetuated non-coordination of care between the two contexts. The low level of literacy of patients and their relatives are mentioned as a cause for not understanding the information regarding seeking primary health care services and handing the discharge letter. It was concluded that there is an urgent need to mobilize health teams toward action in the patients’ process of returning home, and this factor must be taken into account in care planning.
Pediatric Hospitalization for Varicella in an Italian Pediatric Hospital: How Much Does It Cost?
Authors: Bozzola Elena , Spina Giulia , Marchili Maria Rosaria , Brusco Carla , Guolo Stefano , Rossetti Chiara , Logrieco Giuseppe , Pignatelli Francesca , Raponi Massimiliano , Villani Alberto
Published: November 2021

Background: Varicella is a common pediatric infection. Even if it generally has a benign course, it may complicate and require hospitalization. The aim of our study was to estimate the acute hospitalization cost (AHC) for varicella in the acute phase in a pediatric population. Methods: We calculated the AHC of pediatric patients admitted for varicella at Bambino Gesù Children Hospital, Rome, Italy, from 1 November 2005 to 1 November 2020. Results: In the study period, 825 pediatric patients affected by varicella were hospitalized. The mean hospitalization cost was EUR 4015.35 (range from EUR 558.44 to EUR 42,608.00). Among patients, 55% were unvaccinable due to either their age or their immunosuppression status. They would benefit from herd immunity, reducing the overall AHC by EUR 182,196,506. Since the introduction of the compulsory vaccination against varicella in Italy, we observed a significant reduction in AHC cost of 60.6% in 2019 and of 93.5% in 2020. Finally, from the beginning of the COVID-19 pandemic, we documented a decline of 81.2% and 76.9% in varicella hospitalization, compared to 2018 and 2019, respectively. Conclusions: Varicella AHC is an important economic and health assessment point and can be useful for improving preventive strategies.
Extreme Climate Shocks and Green Agricultural Development: Evidence from the 2008 Snow Disaster in China
Authors: Feng Litao , Li Zhuo , Zhao Zhihui
Published: November 2021

Extreme climate shocks cause agricultural yield reductions and increase long-term climate risk, altering farmers’ long-term production decisions and affecting green agricultural development (GAD). We take the 2008 snow disaster in China as an extreme climate shock, calculate the GAD index by the entropy weighting method, and use the difference-in-difference method to study the extreme climate shock’s impact on GAD. The results show that: (1) Extreme climate shocks are detrimental to GAD, with the snow disaster decreasing China’s GAD level by 3.07%. (2) The impacts of extreme climate shocks are heterogeneous across climate and economic zones, with greater impact in humid and developed regions. (3) Extreme climate shocks affect GAD mainly by reducing farmers’ willingness to cultivate, and increasing energy consumption, fertilizer, and pesticide input. (4) Extreme climate shocks do not reduce agricultural yields in the long run. Still, they reduce the total value of agricultural production and decrease the quality of agricultural products expressed in terms of unit value. The findings of this study have policy implications for developing countries in coping with extreme climate shocks and promoting GAD.
Effects of Positive Psychology Interventions on the Well-Being of Young Children: A Systematic Literature Review
Authors: Benoit Valérie , Gabola Piera
Published: November 2021

Over the last 20 years, the effectiveness of positive psychology interventions for the development of the well-being of children and adolescents and the moderation of high levels of anxiety and depression in this population has been largely demonstrated. Emphasis has been placed on the promotion of well-being and prevention of mental health problems in the school context in order to foster, through positive psychology, the cognitive and socio-emotional development of primary and secondary students, e.g., by strengthening positive relationships, positive emotions, character strengths, optimism, and hope. However, little is known about the impact of these interventions on young children. This systematic review aims at examining the effects of positive psychology interventions on the well-being of early childhood children (<6 years old), both in the preschool education context with educators or teachers and also in the family context with parents. Several electronic databases were searched, and the findings systematically reviewed and reported by the PRISMA guidelines. Very few studies met the inclusion criteria (n = 3), highlighting the need for further research in this area. Indeed, all of the selected studies demonstrated the importance of positive psychology interventions with young children to promote positive aspects of development, such as gratitude, positive emotions, life satisfaction, accomplishment, positive relationship, or self-esteem. Limitations in the field are discussed.
Different Effects of Robot-Assisted Gait and Independent Over-Ground Gait on Foot Plantar Pressure in Incomplete Spinal Cord Injury: A Preliminary Study
Authors: Bae Young-Hyeon , Chang Won Hyuk , Fong Shirley S. M.
Published: November 2021

Background: There is insufficient evidence to establish the optimal treatment protocol for robot-assisted gait training. Objective: This study aimed to analyze the effects of robot-assisted gait and independent over-ground gait on foot pressure and to determine an effective training protocol for improvement of gait pattern in patients with incomplete spinal cord injury due to industrial accidents. Methods: Four patients with incomplete spinal cord injury due to an industrial accident who had gait disturbance underwent measurement of peak foot pressure and stance phase duration using a foot pressure analysis system with robot-assisted gait and independent over-ground gait. Results: The robot-assisted gait condition has lower peak foot pressure and shorter stance phase duration than the independent over-ground gait. Conclusions: In this study, robot-assisted gait was found to limit gait pattern improvement in patients with gait disturbance caused by incomplete spinal cord injury due to industrial accidents. Therefore, future research will be conducted to determine the optimal protocol for robot-assisted gait training for gait pattern improvement.
Individual vs. Team Sports—What’s the Better Strategy for Meeting PA Guidelines in Children?
Authors: Kudlacek Michal
Published: November 2021

There is insufficient evidence from previous studies dealing with structure of sport preferences referring to the interconnection between individual factors (socio-economic status, organized/structured physical activity (PA), location, etc.), although these factors can considerably influence total level of PA as well as the structure of sport preferences. The study investigated associations between PA frequency and specific sports activities according to the intensity with the impact on leisure, sport, and education domain, using data from an international health behavior in school-aged children survey. Participants were fifth and ninth grade students in the Czech Republic (seven schools) and Slovakia (nine schools). The results showed a significant association between intensity in team sports and PA frequency per week. Those who participated in high-intensity team sports were 2.5 times more likely to be more physically active.
Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa Plasmodium falciparum—Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit
Authors: Pereira Pedro H. S. , Garcia Celia R. S.
Published: November 2021

Throughout evolution, the need for single-celled organisms to associate and form a single cluster of cells has had several evolutionary advantages. In complex, multicellular organisms, each tissue or organ has a specialty and function that make life together possible, and the organism as a whole needs to act in balance and adapt to changes in the environment. Sensory organs are essential for connecting external stimuli into a biological response, through the senses: sight, smell, taste, hearing, and touch. The G-protein-coupled receptors (GPCRs) are responsible for many of these senses and therefore play a key role in the perception of the cells’ external environment, enabling interaction and coordinated development between each cell of a multicellular organism. The malaria-causing protozoan parasite, Plasmodium falciparum, has a complex life cycle that is extremely dependent on a finely regulated cellular signaling machinery. In this review, we summarize strong evidence and the main candidates of GPCRs in protozoan parasites. Interestingly, one of these GPCRs is a sensor for K+ shift in Plasmodium falciparum, PfSR25. Studying this family of proteins in P. falciparum could have a significant impact, both on understanding the history of the evolution of GPCRs and on finding new targets for antimalarials.
Unravel the Local Complexity of Biological Environments by MALDI Mass Spectrometry Imaging
Authors: Sgobba Elvira , Daguerre Yohann , Giampà Marco
Published: November 2021

Classic metabolomic methods have proven to be very useful to study functional biology and variation in the chemical composition of different tissues. However, they do not provide any information in terms of spatial localization within fine structures. Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) does and reaches at best a spatial resolution of 0.25 μm depending on the laser setup, making it a very powerful tool to analyze the local complexity of biological samples at the cellular level. Here, we intend to give an overview of the diversity of the molecules and localizations analyzed using this method as well as to update on the latest adaptations made to circumvent the complexity of samples. MALDI MSI has been widely used in medical sciences and is now developing in research areas as diverse as entomology, microbiology, plant biology, and plant–microbe interactions, the rhizobia symbiosis being the most exhaustively described so far. Those are the fields of interest on which we will focus to demonstrate MALDI MSI strengths in characterizing the spatial distributions of metabolites, lipids, and peptides in relation to biological questions.
Rotating Magnetic Field Increases β-Lactam Antibiotic Susceptibility of Methicillin-Resistant Staphylococcus aureus Strains
Authors: Woroszyło Marta , Ciecholewska-Juśko Daria , Junka Adam , Drozd Radosław , Wardach Marcin , Migdał Paweł , Szymczyk-Ziółkowska Patrycja , Styburski Daniel , Fijałkowski Karol
Published: November 2021

Methicillin-resistant strains of Staphylococcus aureus (MRSA) have developed resistance to most β-lactam antibiotics and have become a global health issue. In this work, we analyzed the impact of a rotating magnetic field (RMF) of well-defined and strictly controlled characteristics coupled with β-lactam antibiotics against a total of 28 methicillin-resistant and sensitive S. aureus strains. The results indicate that the application of RMF combined with β-lactam antibiotics correlated with favorable changes in growth inhibition zones or in minimal inhibitory concentrations of the antibiotics compared to controls unexposed to RMF. Fluorescence microscopy indicated a drop in the relative number of cells with intact cell walls after exposure to RMF. These findings were additionally supported by the use of SEM and TEM microscopy, which revealed morphological alterations of RMF-exposed cells manifested by change of shape, drop in cell wall density and cytoplasm condensation. The obtained results indicate that the originally limited impact of β-lactam antibiotics in MRSA is boosted by the disturbances caused by RMF in the bacterial cell walls. Taking into account the high clinical need for new therapeutic options, effective against MRSA, the data presented in this study have high developmental potential and could serve as a basis for new treatment options for MRSA infections.
Mechanisms of CP190 Interaction with Architectural Proteins in Drosophila Melanogaster
Authors: Sabirov Marat , Popovich Anastasia , Boyko Konstantin , Nikolaeva Alena , Kyrchanova Olga , Maksimenko Oksana , Popov Vladimir , Georgiev Pavel , Bonchuk Artem
Published: November 2021

Most of the known Drosophila architectural proteins interact with an important cofactor, CP190, that contains three domains (BTB, M, and D) that are involved in protein–protein interactions. The highly conserved N-terminal CP190 BTB domain forms a stable homodimer that interacts with unstructured regions in the three best-characterized architectural proteins: dCTCF, Su(Hw), and Pita. Here, we identified two new CP190 partners, CG4730 and CG31365, that interact with the BTB domain. The CP190 BTB resembles the previously characterized human BCL6 BTB domain, which uses its hydrophobic groove to specifically associate with unstructured regions of several transcriptional repressors. Using GST pull-down and yeast two-hybrid assays, we demonstrated that mutations in the hydrophobic groove strongly affect the affinity of CP190 BTB for the architectural proteins. In the yeast two-hybrid assay, we found that architectural proteins use various mechanisms to improve the efficiency of interaction with CP190. Pita and Su(Hw) have two unstructured regions that appear to simultaneously interact with hydrophobic grooves in the BTB dimer. In dCTCF and CG31365, two adjacent regions interact simultaneously with the hydrophobic groove of the BTB and the M domain of CP190. Finally, CG4730 interacts with the BTB, M, and D domains of CP190 simultaneously. These results suggest that architectural proteins use different mechanisms to increase the efficiency of interaction with CP190.