bluuebunny/crossref_metadata_2025 huggingface dataset:
Changing Patterns of the Flow Ratio with the Distance of Exhaust and Supply Hood in a Parallel Square Push-Pull Ventilation
Authors: Chen Jianwu
Published: March 2022

The method of flow ratio k is often used for designing parallel push-pull ventilation. The k value is mostly selected empirically and is difficult to determine accurately, resulting in an imprecise design of the push-pull ventilation system. Therefore, parallel push-pull ventilation was taken as the research object in this paper. The push-pull ventilation studied consists of a square uniform supply hood and a square uniform exhaust hood, and the side length of pull hood and pull hood was same. A workbench was set between the push hood and pull hood, and the source of toluene pollutions was set in the center of the worktable surface. The optimal k values for different distances between push hood and pull hood were studied by numerical simulation using Ansys Fluent, which were obtained base on the distribution of wind speed and toluene concentration. The results showed that parallel push-pull ventilation is not suitable for applications when L/a ≥ 6. The changing patterns of k value with L/a is proposed in the range of 1.5 ≤ L/a ≤ 5 for the parallel square push-pull ventilation, which can be used to estimate k value relatively accurately under the condition that L/a is known, so as to guide the determination of the exhaust air volume of the parallel push-pull ventilation system.
Data-Driven Prediction for COVID-19 Severity in Hospitalized Patients
Authors: Alrajhi Abdulrahman A. , Alswailem Osama A. , Wali Ghassan , Alnafee Khalid , AlGhamdi Sarah , Alarifi Jhan , AlMuhaideb Sarab , ElMoaqet Hisham , AbuSalah Ahmad
Published: March 2022

Clinicians urgently need reliable and stable tools to predict the severity of COVID-19 infection for hospitalized patients to enhance the utilization of hospital resources and supplies. Published COVID-19 related guidelines are frequently being updated, which impacts its utilization as a stable go-to resource for informing clinical and operational decision-making processes. In addition, many COVID-19 patient-level severity prediction tools that were developed during the early stages of the pandemic failed to perform well in the hospital setting due to many challenges including data availability, model generalization, and clinical validation. This study describes the experience of a large tertiary hospital system network in the Middle East in developing a real-time severity prediction tool that can assist clinicians in matching patients with appropriate levels of needed care for better management of limited health care resources during COVID-19 surges. It also provides a new perspective for predicting patients’ COVID-19 severity levels at the time of hospital admission using comprehensive data collected during the first year of the pandemic in the hospital. Unlike many previous studies for a similar population in the region, this study evaluated 4 machine learning models using a large training data set of 1386 patients collected between March 2020 and April 2021. The study uses comprehensive COVID-19 patient-level clinical data from the hospital electronic medical records (EMR), vital sign monitoring devices, and Polymerase Chain Reaction (PCR) machines. The data were collected, prepared, and leveraged by a panel of clinical and data experts to develop a multi-class data-driven framework to predict severity levels for COVID-19 infections at admission time. Finally, this study provides results from a prospective validation test conducted by clinical experts in the hospital. The proposed prediction framework shows excellent performance in concurrent validation (n=462 patients, March 2020–April 2021) with highest discrimination obtained with the random forest classification model, achieving a macro- and micro-average area under receiver operating characteristics curve (AUC) of 0.83 and 0.87, respectively. The prospective validation conducted by clinical experts (n=185 patients, April–May 2021) showed a promising overall prediction performance with a recall of 78.4–90.0% and a precision of 75.0–97.8% for different severity classes.
Exposure to High Precariousness Prevalence Negatively Impacts Drug Prescriptions of General Practitioners to Precarious and Non-Precarious Populations: A Retrospective Pharmaco-Epidemiological Study
Authors: Birault François , Le Bonheur Lakshmipriva , Langbour Nicolas , Clodion Sandivanie , Jaafari Nematollah , Perault-Pochat Marie-Christine , Thirioux Bérangère
Published: March 2022

(1) Background: Precarious patients are more difficult to care for due to low literacy rates and poor adherence to treatment and hospitalization. These difficulties have detrimental effects on general practitioners (GPs), deteriorating medical communication, advice, diagnoses, and drug prescriptions. To better understand how precariousness affects primary care, we tested whether, among GPs, exposure to high precariousness prevalence more severely impacts drug prescriptions to precarious and non-precarious populations compared to low precariousness prevalence. Materials and methods: This pharmaco-epidemiological study, using linear regression analyses, compared the defined daily dose of 20 drugs prescribed by GPs to precarious and non-precarious patients in four French regions with low and high precariousness prevalence in 2015. (2) Findings: Exposure to high precariousness prevalence significantly impacted the prescriptions of nine medications to precarious patients and two medications to non-precarious patients, and distributed into three interaction patterns. (3) Interpretation: The selective over-prescription of drugs with easy intake modalities to precarious patients probably reflects GPs’ attempts to compensate for poor patient compliance. In contrast, the under-prescription of drugs targeting fungal infections in precarious populations and diabetes and cardiovascular diseases in non-precarious populations was seemingly due to a breakdown of empathy and professional exhaustion, causing medical neglect.
Continuing Bonds after Loss by Suicide: A Systematic Review
Authors: Goodall Rebecca , Krysinska Karolina , Andriessen Karl
Published: March 2022

The concept of continuing bonds as an alternative to detachment from the deceased person has gained traction in grief literature over the years. Those bereaved by suicide are likely to experience various grief reactions and may be at-risk for adverse grief and mental health outcomes. However, it remains unclear how those bereaved by suicide experience continuing bonds. To address this gap, we conducted a systematic review according to PRISMA guidelines. Searches of peer-reviewed literature in Medline, PsycINFO, Embase, Emcare, EBM Reviews, and Scopus identified 15 studies (2 quantitative and 13 qualitative) reporting on 12 samples, published between 2010 and 2021. The study quality of the quantitative studies was poor, but it was fair amongst the qualitative studies. People bereaved by suicide experienced continuing bonds across a variety of domains and reported mostly positive experiences. Factors that tended to have an impact on the expression of continuing bonds included time since bereavement, relationship to the deceased, social expectations, sex of the bereaved, and the ability of the bereaved to make meaning of the death. The review concludes that most participants reported positive experiences with continuing bonds. However, discrepancies between males and females and between those bereaved by suicide and those bereaved by other causes warrants further investigation. In addition, longitudinal community-based research involving representative samples is needed to understand the evolution and experience of continuing bonds over time in those bereaved by suicide and to inform future efforts in supporting them.
Natural Compounds for Counteracting Nonalcoholic Fatty Liver Disease (NAFLD): Advantages and Limitations of the Suggested Candidates
Authors: Salvoza Noel , Giraudi Pablo J. , Tiribelli Claudio , Rosso Natalia
Published: March 2022

The booming prevalence of nonalcoholic fatty liver disease (NAFLD) in adults and children will threaten the health system in the upcoming years. The “multiple hit” hypothesis is the currently accepted explanation of the complex etiology and pathophysiology of the disease. Some of the critical pathological events associated with the development of NAFLD are insulin resistance, steatosis, oxidative stress, inflammation, and fibrosis. Hence, attenuating these events may help prevent or delay the progression of NAFLD. Despite an increasing understanding of the mechanisms involved in NAFLD, no approved standard pharmacological treatment is available. The only currently recommended alternative relies on lifestyle modifications, including diet and physical activity. However, the lack of compliance is still hampering this approach. Thus, there is an evident need to characterize new therapeutic alternatives. Studies of food bioactive compounds became an attractive approach to overcome the reticence toward lifestyle changes. The present study aimed to review some of the reported compounds with beneficial properties in NAFLD; namely, coffee (and its components), tormentic acid, verbascoside, and silymarin. We provide details about their protective effects, their mechanism of action in ameliorating the critical pathological events involved in NAFLD, and their clinical applications.
Study on Spectral Selective Manipulation Characteristics of Surface Multilevel Micro–Nano Structures by FDTD Simulation
Authors: Guo Xiangjing , Song Haiying , Du Bairui , Tan Shengwang , Liu Shibing
Published: March 2022

The optical filter based on the micro–nano structure on the material surface is an important optical device, which is widely used in many fields. The filter is fabricated on the substrate with different shapes and sizes of micro–nano array structure, and the wavelength selectivity is realized by adjusting the processing parameters. In this paper, the finite-difference time-domain (FDTD) method is used to simulate the spectral properties of periodic array structures on the Au surface, and the spectral response characteristics of different surface structural parameters to the incident light are obtained. The simulation results show that the periodic pore array has a directional modulation function on the reflectivity and transmittance of the material surface. In the same circular aperture array structure, the wavelength selection ability is proportional to the interval distance of the array period, but the transmission peak linewidth decreases with the increase of the interval distance. The structural spectrum of the cylindrical array is closely related to the structural period. The period of the array structure increases in proportion, the center wavelengths of the reflection and transmission peak of the spectrum are red-shifted. When the height of the array structure increases proportionally, the positions of the center wavelengths of the reflection and transmission peak remain almost unchanged. When the period of the array structure increases, the center wavelength of the reflection and transmission peaks appear red-shifted, and the line width is also narrowed. For the periodic ring array structure, as the inner diameter increases, the reflection peak is significantly red-shifted, and the smaller the ring width, the faster the red-shift of the reflection peak with the wavelength. By controlling the ratio of inner diameter-to-outer diameter, the spectral characteristics of the structured surface can be effectively controlled. These simulation results provide a basis for the preparation of optical filters in the future and a new idea for the study of micro–nano characteristic structures on the surface of materials.
Myocardial GRK2 Reduces Fatty Acid Metabolism and β-Adrenergic Receptor-Mediated Mitochondrial Responses
Authors: Zhai Ruxu , Varner Erika L. , Rao Ajay , Karhadkar Sunil , Di Carlo Antonio , Snyder Nathaniel W. , Sato Priscila Y.
Published: March 2022

G-protein coupled receptor (GPCR) kinase 2 (GRK2) is upregulated in heart failure (HF) patients and mouse models of cardiac disease. GRK2 is a regulator of β-adrenergic receptors (βARs), a GPCR involved in ionotropic and chronotropic responses. We and others have recently reported GRK2 to be localized in the mitochondria, although its function in the mitochondria and/or metabolism remain not clearly defined. We hypothesized that upregulation of GRK2 reduced mitochondrial respiratory function and responses to βAR activation. Utilizing isolated mouse primary adult cardiomyocytes (ACMs), we investigated the role of glucose, palmitate, ketone bodies, and BCAAs in mediating cell survival. Our results showed that myocyte upregulation of GRK2 promotes palmitate-induced cell death. Isotopologue labeling and mass spectrometry showed that the upregulation of GRK2 reduces β-hydroxybutyryl CoA generation. Next, using isoproterenol (ISO), a non-selective βAR-agonist, we determined mitochondrial function in mouse and human primary ACMs. Upregulation of GRK2 impaired ISO-mediated mitochondrial functional responses, which we propose is important for metabolic adaptations in pathological conditions. Increased cardiac levels of GRK2 reduced fatty acid-specific catabolic pathways and impaired ISO-stimulated mitochondrial function. Our data support the notion that GRK2 participates in bioenergetic remodeling and may be an important avenue for the development of novel pharmacological strategies in HF.
The Plastome Sequences of Triticum sphaerococcum (ABD) and Triticum turgidum subsp. durum (AB) Exhibit Evolutionary Changes, Structural Characterization, Comparative Analysis, Phylogenomics and Time Divergence
Authors: Lubna Lubna , Asaf Sajjad , Jan Rahmatullah , Khan Abdul Latif , Ahmad Waqar , Asif Saleem , Al-Harrasi Ahmed , Kim Kyung-Min , Lee In-Jung
Published: March 2022

The mechanism and course of Triticum plastome evolution is currently unknown; thus, it remains unclear how Triticum plastomes evolved during recent polyploidization. Here, we report the complete plastomes of two polyploid wheat species, Triticum sphaerococcum (AABBDD) and Triticum turgidum subsp. durum (AABB), and compare them with 19 available and complete Triticum plastomes to create the first map of genomic structural variation. Both T. sphaerococcum and T. turgidum subsp. durum plastomes were found to have a quadripartite structure, with plastome lengths of 134,531 bp and 134,015 bp, respectively. Furthermore, diploid (AA), tetraploid (AB, AG) and hexaploid (ABD, AGAm) Triticum species plastomes displayed a conserved gene content and commonly harbored an identical set of annotated unique genes. Overall, there was a positive correlation between the number of repeats and plastome size. In all plastomes, the number of tandem repeats was higher than the number of palindromic and forward repeats. We constructed a Triticum phylogeny based on the complete plastomes and 42 shared genes from 71 plastomes. We estimated the divergence of Hordeum vulgare from wheat around 11.04–11.9 million years ago (mya) using a well-resolved plastome tree. Similarly, Sitopsis species diverged 2.8–2.9 mya before Triticum urartu (AA) and Triticum monococcum (AA). Aegilops speltoides was shown to be the maternal donor of polyploid wheat genomes and diverged ~0.2–0.9 mya. The phylogeny and divergence time estimates presented here can act as a reference framework for future studies of Triticum evolution.
Characterization of the Wheat Heat Shock Factor TaHsfA2e-5D Conferring Heat and Drought Tolerance in Arabidopsis
Authors: Bi Huihui , Miao Jingnan , He Jinqiu , Chen Qifan , Qian Jiajun , Li Huanhuan , Xu Yan , Ma Dan , Zhao Yue , Tian Xuejun , Liu Wenxuan
Published: March 2022

Environmental stresses, especially heat and drought, severely limit plant growth and negatively affect wheat yield and quality worldwide. Heat shock factors (Hsfs) play a central role in regulating plant responses to various stresses. In this study, the wheat heat shock factor gene TaHsfA2e-5D on chromosome 5D was isolated and functionally characterized, with the goal of investigating its role in responses to heat and drought stresses. Gene expression profiling showed that TaHsfA2e-5D was expressed constitutively in various wheat tissues, most highly in roots at the reproductive stage. The expression of TaHsfA2e-5D was highly up-regulated in wheat seedlings by heat, cold, drought, high salinity, and multiple phytohormones. The TaHsfA2e-5D protein was localized in the nucleus and showed a transcriptional activation activity. Ectopic expression of the TaHsfA2e-5D in yeast exhibited improved thermotolerance. Overexpression of the TaHsfA2e-5D in Arabidopsis results in enhanced tolerance to heat and drought stresses. Furthermore, RT-qPCR analyses revealed that TaHsfA2e-5D functions through increasing the expression of Hsp genes and other stress-related genes, including APX2 and GolS1. Collectively, these results suggest that TaHsfA2e-5D functions as a positive regulator of plants’ responses to heat and drought stresses, which may be of great significance for understanding and improving environmental stress tolerance in crops.
Experimental Validation of an Analytical Condensation Model for Application in Steam Turbine Design
Authors: Lapp Florian Felix , Schuster Sebastian , Hecker Simon , Brillert Dieter
Published: March 2022

This paper presents experimental data on shear-stress-driven liquid water films on a horizontal plate formed by the condensation of superheated steam. The experimental results were obtained in the Experimental Multi-phase Measurement Application (EMMA) at the University of Duisburg-Essen. The liquid film thickness was spatially and temporally investigated with an optical measurement system. Furthermore, the resulting local heat transfer coefficient in the case of film condensation was determined for a variety of steam velocities and temperatures. Subsequently, the presented data are compared to the results of an analytical condensation model for shear-stress-driven liquid films developed by Cess and Koh. Thus, the model is qualitatively validated, with explicable remaining disparities between the model and experiment that are further discussed. The presented results are an important contribution to the contemporary research into steady-state, single-component multiphase flow considering phase-change phenomena including heat transfer.
Navigations for Hospitality Human Resource Management Research: Observing the Keywords, Factors, Topics under the COVID-19 Pandemic
Authors: Wang Jue , Ban Hyun-Jeong , Joung Hyun-Woo , Kim Hak-Seon
Published: March 2022

The hospitality industry is one of the most affected by the pandemic, and because of its human close interaction and labor-intensive characteristics, it has left Human Resource Management (HRM) puzzles with organizations’ stabilization and recovery. This study aimed to summarize current research on hospitality HRM research outcomes and trends during the COVID-19 pandemic. Utilizing the PRISMA technique and NVivo software, 102 research articles were extracted and analyzed to highlight to overall achievement and movement of hospitality HRM research under the shadow of the COVID-19 crisis. Considering the main purpose of this study, which was to show the status and prospects, the findings indicated 309 free nodes and 26 secondary nodes based on grounded theory. 7 key themes clustered from the analysis and include “environmental factors”, “industrial factors”, “HRM practice”, “organization”, “employee”, “external outcomes”, and “methodology”. The results demonstrated the COVID-19 pandemic driven HRM transformation. In addition, it sheds light on how research responds to the shifting navigation of HRM within the hospitality context under the COVID-19 conditions.
Text Mining with Network Analysis of Online Reviews and Consumers’ Satisfaction: A Case Study in Busan Wine Bars
Authors: Fu Wei , Choi Eun-Kyong , Kim Hak-Seon
Published: March 2022

With the growth of internet technology, customers are sharing up their experiences. Hence, these types of customer experiences are spreading rapidly as a source of online reviews. For this reason, online reviews have become a critical source of information that influences customers’ purchase intentions and behavior. Thus, businesses should monitor online reviews to understand the customer experience and increase customer satisfaction and loyalty. This study attempts to identify essential characteristics for positive online reviews of wine bars and examine the structural relationships of these attributes. To accomplish this purpose, a total of 1,337 online reviews were collected from Google Travel and analyzed. The frequency analysis was performed using text mining to determine the most frequently referred to attributes, and the semantic network analysis, factor analysis, and regression analysis were conducted to understand customer experience and satisfaction of wine bars located in Busan, South Korea. The results show that the top 50 keywords identified from the online reviews were categorized as four groups—‘Atmosphere’, ‘Service’, ‘Date and Location’, and ‘Menu’. The results of the factor analysis reduced the original dimension of 48 keywords to 16 keywords and classified them into six factors, namely, ‘Service’, ‘Staff’, ‘Menu’, ‘Environment’, ‘Recommendation’ and ‘Atmosphere’. Based on these results, implications for sustainable wine bar marketing strategies were suggested.
Towards the Detection of Fake News on Social Networks Contributing to the Improvement of Trust and Transparency in Recommendation Systems: Trends and Challenges
Authors: Stitini Oumaima , Kaloun Soulaimane , Bencharef Omar
Published: March 2022

In the age of the digital revolution and the widespread usage of social networks, the modalities of information consumption and production were disrupted by the shift to instantaneous transmission. Sometimes the scoop and exclusivity are just for a few minutes. Information spreads like wildfire throughout the world, with little regard for context or critical thought, resulting in the proliferation of fake news. As a result, it is preferable to have a system that allows consumers to obtain balanced news information. Some researchers attempted to detect false and authentic news using tagged data and had some success. Online social groups propagate digital false news or fake news material in the form of shares, reshares, and repostings. This work aims to detect fake news forms dispatched on social networks to enhance the quality of trust and transparency in the social network recommendation system. It provides an overview of traditional techniques used to detect fake news and modern approaches used for multiclassification using unlabeled data. Many researchers are focusing on detecting fake news, but fewer works highlight this detection’s role in improving the quality of trust in social network recommendation systems. In this research paper, we take an improved approach to assisting users in deciding which information to read by alerting them about the degree of inaccuracy of the news items they are seeing and recommending the many types of fake news that the material represents.
Revision of Carpal Tunnel Surgery
Authors: Pripotnev Stahs , Mackinnon Susan E.
Published: March 2022

Carpal tunnel release is one of the most commonly performed upper extremity procedures. The majority of patients experience significant improvement or resolution of their symptoms. However, a small but important subset of patients will experience the failure of their initial surgery. These patients can be grouped into persistent, recurrent, and new symptom categories. The approach to these patients starts with a thorough clinical examination and is supplemented with electrodiagnostic studies. The step-wise surgical management of revision carpal tunnel surgery consists of the proximal exploration of the median nerve, Guyon’s release with neurolysis, the rerelease of the transverse retinaculum, evaluation of the nerve injury, treatment of secondary sites of compression, and potential ancillary procedures. The approach and management of failed carpal tunnel release are reviewed in this article.
Magnetic Resonance Guided Radiotherapy for Head and Neck Cancers
Authors: Gharzai Laila A. , Rosen Benjamin S. , Mittal Bharat , Mierzwa Michelle L. , Yadav Poonam
Published: March 2022

Radiotherapy is an integral component of head/neck squamous cell carcinomas (HNSCCs) treatment, and technological developments including advances in image-guided radiotherapy over the past decades have offered improvements in the technical treatment of these cancers. Integration of magnetic resonance imaging (MRI) into image guidance through the development of MR-guided radiotherapy (MRgRT) offers further potential for refinement of the techniques by which HNSCCs are treated. This article provides an overview of the literature supporting the current use of MRgRT for HNSCC, challenges with its use, and developing research areas.
Risk Factors of Rejection in Renal Transplant Recipients: A Narrative Review
Authors: Oweira Hani , Ramouz Ali , Ghamarnejad Omid , Khajeh Elias , Ali-Hasan-Al-Saegh Sadeq , Nikbakhsh Rajan , Reißfelder Christoph , Rahbari Nuh , Mehrabi Arianeb , Sadeghi Mahmoud
Published: March 2022

Multiple factors influence graft rejection after kidney transplantation. Pre-operative factors affecting graft function and survival include donor and recipient characteristics such as age, gender, race, and immunologic compatibility. In addition, several peri- and post-operative parameters affect graft function and rejection, such as cold and warm ischemia times, and post-operative immunosuppressive treatment. Exposure to non-self-human leucocyte antigens (HLAs) prior to transplantation up-regulates the recipient’s immune system. A higher rate of acute rejection is observed in transplant recipients with a history of pregnancies or significant exposure to blood products because these patients have higher panel reactive antibody (PRA) levels. Identifying these risk factors will help physicians to reduce the risk of allograft rejection, thereby promoting graft survival. In the current review, we summarize the existing literature on donor- and recipient-related risk factors of graft rejection and graft loss following kidney transplantation.
Percutaneous Coronary Revascularization after Out-of-Hospital Cardiac Arrest: A Review of the Literature and a Case Series
Authors: Scavelli Francesca , Cartella Iside , Montalto Claudio , Oreglia Jacopo Andrea , Villanova Luca , Garatti Laura , Colombo Claudia , Sacco Alice , Morici Nuccia
Published: March 2022

Out-of-hospital cardiac arrest (OHCA) is still associated with high mortality and severe complications, despite major treatment advances in this field. Ischemic heart disease is a common cause of OHCA, and current guidelines clearly recommend performing immediate coronary angiography (CAG) in patients whose post-resuscitation electrocardiogram shows ST-segment elevation (STE). Contrarily, the optimal approach and the advantage of early revascularization in cases of no STE is less clear, and decisions are often based on the individual experience of the center. Numerous studies have been conducted on this topic and have provided contradictory evidence; however, more recently, results from several randomized clinical trials have suggested that performing early CAG has no impact on overall survival in patients without STE.
Nucleic Acid-Based COVID-19 Therapy Targeting Cytokine Storms: Strategies to Quell the Storm
Authors: Abusalah Mai Abdel Haleem , Khalifa Moad , Al-Hatamleh Mohammad A. I. , Jarrar Mu’taman , Mohamud Rohimah , Chan Yean Yean
Published: March 2022

Coronavirus disease 2019 (COVID-19) has shaken the world and triggered drastic changes in our lifestyle to control it. Despite the non-typical efforts, COVID-19 still thrives and plagues humanity worldwide. The unparalleled degree of infection has been met with an exceptional degree of research to counteract it. Many drugs and therapeutic technologies have been repurposed and discovered, but no groundbreaking antiviral agent has been introduced yet to eradicate COVID-19 and restore normalcy. As lethality is directly correlated with the severity of disease, hospitalized severe cases are of the greatest importance to reduce, especially the cytokine storm phenomenon. This severe inflammatory phenomenon characterized by elevated levels of inflammatory mediators can be targeted to relieve symptoms and save the infected patients. One of the promising therapeutic strategies to combat COVID-19 is nucleic acid-based therapeutic approaches, including microRNAs (miRNAs). This work is an up-to-date review aimed to comprehensively discuss the current nucleic acid-based therapeutics against COVID-19 and their mechanisms of action, taking into consideration the emerging SARS-CoV-2 variants of concern, as well as providing potential future directions. miRNAs can be used to run interference with the expression of viral proteins, while endogenous miRNAs can be targeted as well, offering a versatile platform to control SARS-CoV-2 infection. By targeting these miRNAs, the COVID-19-induced cytokine storm can be suppressed. Therefore, nucleic acid-based therapeutics (miRNAs included) have a latent ability to break the COVID-19 infection in general and quell the cytokine storm in particular.
Characteristics of the Third COVID-19 Pandemic Wave with Special Focus on Socioeconomic Inequalities in Morbidity, Mortality and the Uptake of COVID-19 Vaccination in Hungary
Authors: Oroszi Beatrix , Juhász Attila , Nagy Csilla , Horváth Judit Krisztina , Komlós Krisztina Eszter , Túri Gergő , McKee Martin , Ádány Róza
Published: March 2022

Governments are increasingly looking to vaccination to provide a path out of the COVID-19 pandemic. Hungary offers an example to investigate whether social inequalities compromise what a successful vaccine program can achieve. COVID-19 morbidity, mortality, and vaccination coverage were characterized by calculation of indirectly standardized ratios in the Hungarian population during the third pandemic wave at the level of municipalities, classified into deprivation quintiles. Then, their association with socioeconomic deprivation was assessed using ecological regression. Compared to the national average, people living in the most deprived municipalities had a 15–24% lower relative incidence of confirmed COVID-19 cases, but a 17–37% higher relative mortality and a 38% lower vaccination coverage. At an ecological level, COVID-19 mortality showed a strong positive association with deprivation and an inverse association with vaccination coverage (RRVaccination = 0.86 (0.75–0.98)), but the latter became non-significant after adjustment for deprivation (RRVaccination = 0.95 (0.84–1.09), RRDeprivation = 1.10 (1.07–1.14)). Even what is widely viewed as one of the more successful vaccine roll outs was unable to close the gap in COVID-19 mortality during the third pandemic wave in Hungary. This is likely to be due to the challenges of reaching those living in the most deprived municipalities who experienced the highest mortality rates during the third wave.
RETRACTED: Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Damage in Diabetic Rats
Authors: Chung Cheng-Hsun , Chung Shiu-Dong , Cheng Yu-Hsuan , Yang Chun-Pai , Chien Chiang-Ting
Published: March 2022

Exendin-4 (Ex-4) is an incretin mimetic agent approved for diabetes treatment and neuronal protection. However, the required frequent injections restrict its clinical application. We prepared Ex-4-loaded poly(d,l-lactide-co-glycolide) nanoparticles (PEx-4) and investigated their effect on cerebral ischemia/reperfusion (IR) injury associated with micturition center damage-induced cystopathy in diabetic rats. Using ten minutes of bilateral carotid artery occlusion combined with hemorrhage-induced hypotension of the IR model in streptozotocin-induced type 1 diabetic (T1DM) Wistar rats, we compared the effects of Ex-4 and PEx-4 on prefrontal cortex edema, voiding function and oxidative stress including cerebral spinal fluid (CSF) reference H2O2 (RH2O2) and HOCl (RHOCl) levels, endoplasmic reticulum (ER) stress, apoptosis, autophagy and pyroptosis signaling in brain and bladder by Western blot and immunohistochemistry. Single injection of PEx-4 displayed higher CSF antioxidant activity and a long-lasting hypoglycemic effect compared to Ex-4 in rats. T1DM and IR primarily enhanced CSF RH2O2, and pIRE-1/caspase-12/pJNK/CHOP-mediated ER stress, caspase-3/PARP-mediated apoptosis, Beclin-1/LC3B-mediated autophagy and caspase-1/IL-1β-mediated pyroptosis signaling in the damaged brains. Our data further evidenced that PEx-4 were more efficient than Ex-4 in attenuating IR-evoked prefrontal cortex edema, the impairment in micturition center and the enhanced level of CSF RH2O2 and HOCl, ER stress, apoptosis, autophagy and pyroptosis parameters in the damaged brains, but had less of an effect on IR-induced voiding dysfunction in bladders of T1DM rats. In summary, PEx-4 with stronger antioxidant activity and long-lasting bioavailability may efficiently confer therapeutic efficacy to ameliorate IR-evoked brain damage through the inhibitory action on oxidative stress, ER stress, apoptosis, autophagy and pyroptosis signaling in diabetic rats.
Epidemiology of Traumatic Tusk Fractures of Managed Elephants in North America, South America, Europe, Asia and Australia
Authors: Rose Josephine B. , Leeds Austin , LeMont Rachel , Yang Linda M. , Fayette Melissa A. , Proudfoot Jeffry S. , Bowman Michelle R. , Woody Allison , Oosterhuis James , Fagan David A.
Published: March 2022

Elephant tusk fractures are a management and medical challenge that can escalate into life-threatening complications. Here, an international survey was sent to elephant managers to understand the risk factors associated with tusk fractures since 2009, identifying best practices for reducing the incidence. Out of 459 elephants included in the survey, 85 elephants incurred at least one fracture. Though not statistically significant, descriptive statistics identified a trend for both Asian and African elephant males to be more likely to incur a fracture than females. Additionally, the first reported fracture occurred in males of both species approximately ten years earlier in age than females. The most common causes of fractures were conspecific interactions (44.6%), caught tusk in an enclosure or enrichment item (28.4%), and a strike by the elephant of a tusk with an object (12.2%). For social causes, unstable hierarchy (45.5%) and specific agonistic interactions (36.4%) were the most frequently cited fracture causes. Steel gates were associated with 23.8% of fractures caused by enclosure elements. Management changes including tusk trimming, enrichment, training, and re-arranging social groups were found to be important in reducing subsequent fractures, with odds ratios showing that a second tusk fracture was 6.37 times more likely to occur if no management changes occurred after the first fracture. Our data suggests that targeted management strategies in herds with maturing males, unstable social dynamics, and/or high-risk enclosure elements could reduce the frequency of tusk fractures.
Coordinated Relationship between Compactness and Land-Use Efficiency in Shrinking Cities: A Case Study of Northeast China
Authors: Wang Yangyang , Liu Yanjun , Zhou Guolei , Ma Zuopeng , Sun Hongri , Fu Hui
Published: March 2022

Compact development and efficient land use are effective ways to address the development dilemma and boost the vitality of shrinking cities. Moreover, it is critical to investigate the relationship between compactness and land-use efficiency in order to healthily and sustainably develop shrinking cities. This study developed an analytical framework to study the coordinated interaction between urban compactness and land-use efficiency in the context of city shrinkage. Fifteen typical shrinking cities in Northeast China were taken as an example of the phenomenon and the entropy value method and super-slack-based measure model were used to quantitatively measure the compactness and land-use efficiency. Furthermore, the coordinated development level and the coordinated relationship between the two were explored with the help of the coupled coordination degree model as well as the quadrant diagram method. The results of the study show that: (1) The overall level of compactness of 15 shrinking cities in Northeast China was low and the improvement of land-use efficiency was not obvious, while the differences of compactness and land-use efficiency between shrinking cities were significant. (2) The coordination between compactness and land-use efficiency was limited; however, the overall coordination remained intermediate, with significant spatial differences and a tendency to further expand. The problem of lagged development of land-use efficiency in shrinking cities could be characterized as serious. (3) Economic development and population size promote the coordinated development of urban compactness and land-use efficiency, whereas science and technology development, industrial structure, as well as government regulation inhibited the coordinated development of urban compactness and land-use efficiency.
Fostering the Resiliency of Urban Landscape through the Sustainable Spatial Planning of Green Spaces
Authors: Valente Donatella , Marinelli María Victoria , Lovello Erica Maria , Giannuzzi Cosimo Gaspare , Petrosillo Irene
Published: March 2022

Background: It has been recognized that urban green spaces play a crucial role in providing many landscape services. The research aimed at identifying the main knowledge gaps in this framework and to support urban planning, taking into account the spatial configuration of green areas through a pilot study area, and mapping urban landscape services. Methods: In this research, (1) a systematic review, analyzed through a network analysis; (2) an urban pilot study to map the Urban Green Index and, jointly, the spatial composition and configuration of urban green areas, through the integration of three landscape metrics; and (3) the mapping of Urban Landscape Services Index have been carried out. Results: The 37% of the reviewed articles focused on regulating services, while the network analysis identified four clusters. The total Urban Green Index was 26%, and some districts showed a percentage that surpassed it. The total overall Green Connectivity Index was 21%. Some districts were the best providers of landscape services. Conclusions: This research was in line with the EU Joint Science for Policy Report suggesting giving emphasis to the spatial pattern map of green spaces in European cities to provide spatial data available for decision-makers in relation to GI deployment.
Cumulative Severity of Thinned and Unthinned Forests in a Large California Wildfire
Authors: Hanson Chad T.
Published: March 2022

Studies pertaining to fire severity in commercially thinned versus unthinned forests are based on a comparison of tree mortality between the two categories. Commercial thinning is widely conducted on public and private forestlands as a fire management approach designed to reduce fire severity and associated tree mortality. However, tree mortality from thinning itself, prior to the occurrence of the wildfire, is generally not taken into account, which leaves a potentially important source of tree loss, with its associated forest carbon loss and carbon emissions, unreported. This study investigated the “cumulative severity” of commercially thinned and unthinned forests in a large 2021 wildfire, the Antelope fire, occurring within mixed-conifer forests on public lands in northern California, USA. Using published data regarding the percent basal area mortality for each commercial thinning unit that burned in the Antelope fire, combined with percent basal area mortality due to the fire itself from post-fire satellite imagery, it was found that commercial thinning was associated with significantly higher overall tree mortality levels (cumulative severity). More research is needed, in other large forest fires, to determine whether the finding, that commercial thinning killed more trees than it prevented from being killed, is common elsewhere.
The foraging Gene Is Involved in the Presence of Wings and Explorative Behaviours in Parthenogenetic Females of the Aphid Myzus persicae
Authors: Mandrioli Mauro , Manicardi Gian Carlo
Published: March 2022

The foraging gene (for) encodes for a cyclic guanosine monophosphate (cGMP)-dependent protein kinase involved in behavioural plasticity in aphids and in other insects. In this paper, we analysed the complete for sequence in eight clones of the peach potato aphid Myzus persicae, reporting the presence of nonsense and frameshift mutations in three studied clones characterized by a reduced number of winged females and by the absence of exploratory behaviours. Quantitative PCR experiments evidenced similar results in clones possessing for genes with a conserved coding sequence, but low expression levels. The comparison of the for transcriptional level in Myzus persicae persicae and Myzus persicae nicotianae showed very different expression in the two studied M. p. nicotianae clones so that our data did not support a previous hypothesis suggesting that a differential for expression was related to ecological specialization of M. p. nicotianae. In view of its role in both the dispersal of winged females and exploratory behaviours, the screening of the for sequences could be useful for predicting invasions of cultivated areas by peach potato aphids.
Disinfection Potential of 980 nm Diode Laser and Hydrogen Peroxide (3%) in “Critical Probing Depths” Periodontal Pockets: Retrospective Study
Authors: El Mobadder Marwan , Nammour Samir , Namour Melanie , Namour Amaury , Grzech-Leśniak Kinga
Published: March 2022

A successful treatment of periodontitis depends largely on the successful elimination of the periodontopathogens during non-surgical and surgical mechanical debridement. In this retrospective study, data collection was conducted from 2017 to 2021. The retrospective study included 128 patients with 128 sites of localized periodontitis with pocket depths > 5 mm. The included data were based on sites that received conventional mechanical debridement followed by different adjunctive approaches. In total, 30 patients did not receive any additional treatment (SRP group), 30 patients received SRP + 980 nm diode laser irradiation only (SRP + laser), 30 patients received SRP + 3% hydrogen peroxide irrigation (SRP + H2O2) only and 30 patients received a combined treatment of 3% hydrogen peroxide and 980 nm diode laser irradiation (SRP + H2O2 + laser). Total bacterial counts (TBC) in the periodontal pocket collected for all participants before treatment, immediately after treatment, 6 weeks after treatment, 12 weeks after treatment and 6 months after treatment were statistically analyzed and compared. When the laser was used, irradiation parameters were 10 μsec/pulse duration, 10 kHz, pick power of 10 W, average power of 1 W, irradiation time of one minute with inward and outward movements, and fiber diameter of 320 μm. The irradiation was repeated 3 times/pocket. When hydrogen peroxide was used, the irrigation was conducted for one minute and repeated 3 times. The maximum reduction in TBC was obtained when SRP was coupled with 3% H2O2 irrigation followed by 980 nm diode laser irradiation. After six months of follow-up, a significant reduction in TBC was obtained for the group of SRP + H2O2 + laser when compared to all the other groups, from 7.27 × 107 before intervention to 3.21 × 107 after six months. All three approaches to SRP showed a significant reduction in TBC immediately after treatment. Values were 3.52 × 107, 4.01 × 106, 9.58 × 106, 1.98 × 106 for SRP alone, SRP + diode, SRP + H2O2 and SRP + H2O2 + diode laser, respectively. At 6 months, we saw no significant difference between SRP + laser and SRP + H2O2 with 4.01 × 107 and 4.32 × 107, respectively. This retrospective study reveals that after SRP, irrigation with 3% hydrogen peroxide and irradiation with a 980 nm diode laser within specific treatment protocol can be used as an additional approach to conventional SRP to increase the disinfection of the periodontal pockets > 5 mm.
An Ab Initio Investigation of the Hydration of Lead(II)
Authors: Pye Cory C. , Gunasekara Champika Mahesh
Published: March 2022

The structure of lead(II) is not well known in aqueous solution. The Hartree–Fock and second order Møller–Plesset levels of theory using the CEP, LANL2, and SDD effective core potentials in combination with their associated basis sets, or with the 6-31G* and 6-31+G* basis sets were used to calculate the energies, structures, and vibrational frequencies of Pb2+(H2O)n, n = 0–9, 18. The lead–oxygen distances and totally symmetric stretching frequency of the aqualead(II) ions from different levels of theory were compared with each other, and with solution measurements where available. The calculations support a hemidirected hexacoordinate structure.
6-(2′-(4″-Oxabutyloxy)phenyl)-1,6,11-triaza-3,9,14,17,22,25-hexaoxa-2(1,2)(4-methylbenzena)-10(1,2)(5-methylbenzena)bicyclo(9.8.8)heptacosaphane Sodium Bromide Dichloromethane
Authors: Jochem Matthias , Schollmeyer Dieter , Detert Heiner
Published: March 2022

Potassium ion sensors are important for the study of concentration profiles in tissues. The synthesis of a cryptand suited for potassium ions and the crystal structure of it with a chelated sodium ion are presented.
Simple Strategies to Modulate the pH-Responsiveness of Lignosulfonate-Based Delivery Systems
Authors: Sgarzi Massimo , Gigli Matteo , Giuriato Charlotte , Crestini Claudia
Published: March 2022

The extensive use of non-degradable microplastics in a wide plethora of daily life products is causing serious pollution problems. More ecofriendly solutions are therefore urgently needed. In this context, the use of lignin, a largely available aromatic polymer, may represent a viable option. Due to the self-assembly ability of its molecules, lignin is in fact an ideal matrix for the fabrication of nanostructures. In this study, lignosulfonate microcapsules containing a limonene core were prepared and characterized in terms of their dimensions and of the physicochemical characteristics of the capsule-forming lignosulfonate molecules. The main purpose is to elucidate the key properties governing the pH-responsive behavior of the capsules to be able to achieve better control over the release kinetics of the entrapped compound(s). The results demonstrate that both the molecular weight and the concentration of sulfonate groups are the most important factors in this respect. Based on these findings, two strategies were followed to further tailor the capsules’ behavior: (i) fractionation of the starting lignosulfonate by solvent extraction and (ii) introduction of a specific additive in the formulation. The first approach permitted to fabricate highly resistant capsules both in acidic, as well as in alkaline conditions, while in the second case the chemical structure of the additive, the diester diveratryl sebacate, allowed for fast kinetics of release, as values above 70% were reached after 24 h of incubation at pH 4 and pH 12.