bluuebunny/crossref_metadata_2025 huggingface dataset:
Construcción de una escala de inteligencias múltiples en la adultez tardía (IMELAT)
Authors:   , Vega Gómez Mario Fernando de Jesús
Published: November 2022

Las inteligencias múltiples es una variable estudiada en distintas etapas del desarrollo, sin embargo, se encontró un vacío dentro de la población de adultos mayores. Es por ello que, la presente investigación tiene el objetivo de construir la escala de inteligencias múltiples en la adultez tardía (IMELAT) con propiedades psicométricas válidas y confiables. La muestra estuvo conformada por 385 adultos mayores de la ciudad de Lima. Esta investigación es de corte cuantitativo psicométrico, con un diseño transversal no experimental. Se logró con éxito la creación de este instrumento con un nivel de confiabilidad de ,91; Para la validez de contenido se tomó en cuenta el criterio de 5 jueces obteniendo un coeficiente de V de Aiken de ,95. Se concluye que es posible crear bajo la teoría de inteligencias múltiples un instrumento para la población de adultos mayores, además de la creación de los baremos para su interpretación.
Multimodal Metadata Assignment for Cultural Heritage Artifacts
Authors: Rei Luis , Mladenic Dunja , Dorozynski Mareike , Rottensteiner Franz , Schleider Thomas , Troncy Raphaël , Lozano Jorge Sebastián , Salvatella Mar Gaitán
Published: November 2022

We develop a multimodal classifier for the cultural heritage domain using a late fusion approach and introduce a novel dataset. The three modalities are Image, Text, and Tabular data. We based the image classifier on a ResNet convolutional neural network architecture and the text classifier on a multilingual transformer architecture (XML-Roberta). Both are trained as multitask classifiers and use the focal loss to handle class imbalance. Tabular data and late fusion are handled by Gradient Tree Boosting. We also show how we leveraged specific data models and taxonomy in a Knowledge Graph to create the dataset and to store classification results. All individual classifiers accurately predict missing propertiesin the digitized silk artifacts, with the multimodal approach providing the best results.
Comparison of Lidocaine and Mepivacaine for Variation on Regional Tissue Oxygenation in Stellate Ganglion Block: A Randomized, Double-blind, Crossover Trial
Authors: Kuroda Hidetaka , Yasuda Michiko , Katagiri Norika , Kagawa Keita , Imaizumi Uno , Ishikawa Noboru , Kido Kanta , Shibukawa Yoshiyuki , Morimoto Yoshinari , Sanuki Takuro
Published: November 2022

This prospective, randomized, double-blind, crossover trial aimed to investigate the effect of different types of local anesthetics on regional tissue blood oxygenation on the stellate ganglion block (SGB). Twenty eligible patients were recruited for this study, 16 of which were allocated to the study protocol. Participants were randomized into one of the two crossover sequences to 1% lidocaine hydrochloride or 1% mepivacaine hydrochloride and received SGBs with 6 mL of either local anesthetic, followed by a washout period of more than 24 h, and received SGBs by substituting the two local anesthetics. The tissue oxygenation index (TOI) in the skin near the mental foramen on the blocked side was recorded using near-infrared spectroscopy at 15 min after the local anesthetic injection. One participant did not complete the study. As such, variation in regional tissue oxygenation was compared between the 15 participants. There was no difference in the increase in regional tissue blood flow or tissue oxygenation after SGB between lidocaine and mepivacaine; however, the kinetics of the increase in regional tissue oxygenation were significantly faster with mepivacaine than with lidocaine. This study was registered in the UMIN Clinical Trials Registry (UMIN000040404) and the authors declare that they have no funding.
DefA-Net: A Multi-Scale Deformable Attention Based MRI Image Segmentation Network
Authors: Zhang Shujun , Peng Zhong , Wang Hongyan , Meng Jianli
Published: November 2022

Accurate medical image segmentation is very important for disease diagnosis and treatment planning. The existing segmentation networks have achieved good performance in some medical image segmentation tasks. However, due to the complex conditions of lesions in size, shape, texture and boundary irregularity, current methods still have limitations. In this paper, we propose a multi-scale deformable attention-based MRI image segmentation network DefA-Net, which can fully utilize the context information and explore the exact lesion boundaries. In order to enhance the learning ability of the network, the bounding boxof the Ground Truth (GT) focus profile is used as auxiliary information to guide feature extraction through different scales and angles. A high-level feature weighted sampling fusion decoder is put forward generating suitable decoding results according to the influence of different high-level features and the deformable attention together with the reverse attention mechanism isapplied to locate detailed boundary clues to improve the accuracy. We also apply DefA-Net to our lesion-detection datasetStrokeQD in transfer learning mode and good segmentation results are acquired. Experiments on ISLES and StrokeQD provethe high accuracy and applicability of the proposed algorithm.
Corticostriatal Structural Connectivity and Integrity in Children with Hydrocephalus and Executive Dysfunction
Authors: Ghahari Daamoon , Morton J. B. , Eagleson Roy , de Ribaupierre Sandrine
Published: November 2022

Purpose
Infantile hydrocephalus causes diffuse neuronal injury and periventricular white matter damage and is a common neurosurgical indication to limit adverse neurodevelopmental outcomes. Higher-order executive functions which develop throughout childhood and adolescence are not currently well characterized in surgically managed patients.
Methods
This case-control diffusion-weighted imaging study measured corticostriatal structural connectivity and integrity in school-aged children with ventriculoperitoneal (VP) shunted infantile hydrocephalus and age-matched controls. Probabilistic tractography and diffusion tensor metrics (such as fractional anisotropy, and mean, radial and axial diffusivity) were used to assess microstructural alterations in the executive corticostriatal network. A bootstrapped correlational analysis was used to identify significant dissimilarity between patient structural networks and the mean control network. The Behaviour Rating Inventory for Executive Functions (BRIEF2), the gold standard for assessing clinically elevated and ecologically valid executive dysfunction in children, was used to obtain three domain measures and one global measure of executive function.
Results
Patients with hydrocephalus showed significant differences of white matter connectivity and integrity within the executive corticostriatal network when compared to the healthy controls. Patients with higher global executive dysfunction demonstrated lower similarity of fractional anisotropy within the executive corticostriatal network when compared to the control network, indicating decreased white matter integrity.
Conclusion
The current study demonstrates patient structural deviation from a control network and highlights atypical development of corticostriatal white matter and related executive dysfunction in children with VP shunted hydrocephalus.
Hesperidin Protects Mitochondrial Permeability Transition Pore of Rat Liver from Toxicity of High-Glucose Concentration and Some Heavy Metals
Authors: FALODE John Adeolu , ADEOYE Akinwunmi Oluwaseun , ADETARA Olajumoke , AJIBOYE Basiru Olaitan , OSO Babatunde J. , OLAOYE Ige F. , AKINMOLADUN Afolabi Clement , OLALEYE Mary Tolulope
Published: November 2022

The mitochondrial membrane permeability transition pore is a transmembrane protein found in the inner membrane of the mitochondria. This protein pore is normally closed, but it opens when the intracellular calcium concentration rises. Apoptosis is associated with pore opening. Heavy metals (including lead, aluminum, and mercury) and high glucose concentrations have been linked to the opening of the mitochondrial membrane permeability pore via the oxidative stress pathway. Hesperidin is a bioflavonoid and a powerful antioxidant found naturally in fruit that can help reduce oxidative stress. This study was designed to look into the protective role of hesperidin on high-glucose concentrations and some heavy metals on the permeability transition pore of the rat mitochondria. Hesperidin was tested for its ability to protect the MMPT pore, mitochondrial lipid peroxidation, cytochrome c release, caspase 3 and 9, and calcium ATPase using standard protocols. Hesperidin was also docked with calcium ATPase, caspase 3, and caspase 9. Hesperidin inhibited pore opening in a concentration dependent manner, according to the findings. Hesperidin also protected mitochondrial integrity, as measured by lipid peroxidation, cytochrome c release, and the activities of caspase 3 and 9, as well as calcium ATPase. Docking studies revealed that hesperidin has a high affinity for calcium ATPase, caspase 3, and caspase 9. As a result, it could be argued that hesperidin is beneficial in treating mitochondrial diseases as well as liver diseases.
Comprehensive diagnosis and individualized treatment of multiple primary lung cancers: a case report
Authors: Zeng Guoxiong , Zhou Yunyan , Lin Yuying , Lin Guanzhou , Chen Chunyuan , Yang Xiao , Liang Zhu
Published: November 2022

Background: With the popularity of low-dose computed tomography (CT), the detection rate of multiple primary lung cancer (MPLC) has gradually increased. However, there is still no unified standard for diagnosing MPLC, and it needs to be differentiated from intrapulmonary metastasis. The treatment strategies and prognosis of the two are different.
Case presentation: A 45-year-old female MPLC patient with more than 20 lesions in both lungs with the enhanced chest CT showed intrapulmonary metastases (IM). She was admitted to the hospital for the purpose of clarifying the pathology of lung lesions and receiving drug therapy. However, Whole-body positron emission tomography (PET) -CT revealed an anterior left upper lobe lesion with increased F18 fluorodeoxyglucose (FDG) metabolism (SUVmax=7.3). No abnormal increase in FDG metabolism was found in the other multiple lesions. It was biased toward diagnosing MPLC. After a multidisciplinary discussion, we developed an individualized treatment plan for this patient. Patients were treated with a second-stage surgery according to the protocol, as well as adjuvant chemotherapy between surgeries. For a total of 21 months from the first surgical treatment, the patient did not experience any disease progression.
Conclusions: Integrating radiological, histopathological, and genomic features by a multidisciplinary team facilitated a more accurate diagnosis of MPLC. It will be a new trend in the differential diagnosis of MPLC in the future. Moreover, an individualised treatment design is more beneficial to patients for MPLC with a large number of lesions in both lungs. We share a case of the diagnosis and individualized treatment of MPLC with ultra-multiple lesions in both lungs, which provides a reference for the diagnosis and treatment of similar patients.
Assessment of Clinical Reasoning in The Evaluation of the Oral Diseases Course in Final-Year Dental Students Using Script Concordance Test (SCT)
Authors: Bashardoust Nazanin , Mohammadpour Hesam , Asgari Fariba , Basirat Maryam , Khoshtarash Mehrnoosh , Mirfarhadi Nastaran
Published: November 2022

Background: SCT, considered a valid alternative to the classical evaluation method, is a distinctive method to evaluate medical students’ clinical reasoning skills. The present study aimed to determine the correlation between SCT and clinical-based classical multiple-choice questions (MCQs) in the clinical evaluation of the course of oral disease among Guilan dental students.
Methods: In this analytical cross-sectional study, 73 final-year students of the dentistry school of Guilan University who had completed oral and dental diseases courses 1 to 5 were investigated. In this study, in addition to the classical MCQ test at the end of the semester, 15 SCT scenarios with three follow-up questions (45 questions in total) were also administered to the students. The difficulty and discrimination coefficients and the correlation coefficient between the SCT and MCQ tests were measured.
Results: The results showed that the mean age of the students was 24.1±59.36, and 53% (39 individuals) were males. Their GPA of the previous semester was 15.42 ± 1.23. Based on the obtained results, a direct and significant relationship was found between the SCT and the MCQ scores (P=0.035); as the SCT scores increased, the MCQ scores increased accordingly.
Conclusions: SCT scores were correlated with the results obtained in the classical MCQ test. It is recommended that more research on SCT be used in formative evaluations.
Development of Specific-Barcode Based on Chloroplast Genome and Its Application in Metabarcoding Molecular Identification of Chinese Patent Medicines Berberidis Radix
Authors: Li Hui , Yang Hongxia , Guo Hua , Zhang Yue , Zhang Tingting , Tuliebieke Tenukeguli , Yan Rushan , Yuan Ye , Li Tianxiang , Li Guohui , Yang Wenzhi , Wang Yu , Chang Yanxu , Tian Xiaoxuan
Published: November 2022

Background
Berberidis Radix (Sankezhen), a typical multi-origin Chinese medicinal material, originates from the dried roots of the Berberis genus plants. Previous studies have shown that there were significant differences in chemical compositions in different Berberis species. Therefore, it was exceedingly important to accurately identify different species of Berberis.
Results
In this study, for the first time, we systematically compared the complete chloroplast genome sequences of the six Berberis species (B. julianae, B. tsienii, B. pruinose, B. thunbergii, B. poiretii and B. wilsoniae), which commonly were used as medicinal herb Berberidis Radix. The ndhD-ccsA as highly divergent region was found and taken as a potential marker for species identification. Subsequently, the barcode was applied to the Chinese patent medicines containing Berberidis Radix (Sankezhen) combined with DNA metabarcoding technology. The results showed that the six complete chloroplast genomes exhibited a typical quadripartite structure which ranging from 165,934 to 168,828 bp in length. A total of 147 unique genes were identified in each chloroplast genome, comprising 101 protein-coding genes, 38 tRNA genes, and 8 rRNA genes. Comparative genome analysis demonstrated that the six chloroplast genomes were highly conserved in genome size, gene organization and GC contents. The phylogenetic relationships of six Berberis plants were revealed and the results showed that Mahonia was supported as separate clade in the Berberis genera tree, which was coincident with previous studies. The nucleotide diversity analysis revealed seven variable loci in protein coding regions, and four variable loci in gene spacer regions, respectively. The primer pair 1508F-1864R on ndhD-ccsA region was proven to precisely discriminate the six studied Berberis species and recovered the biodiversity of Berberis species in Chinese patent medicines.
Conclusions
In general, this study provides meaningful genetic information for Berberis plants, and establishes a method to realize the identification of Berberidis Radix as multi-origin Chinese medicinal materials, which can be applied to Chinese patent medicines containing Berberidis Radix.
Litter species richness and mycorrhizal symbionts improving soil carbon and nitrogen depends on soil macroaggregates and glomalin accrual
Authors: Ji Xiaochao , Wang Shengfang , Guo Siru , Zhao Shuting , Dong Quanxing , Yun Cholil , Zhang Xiting , Yang Yanbo , Wang Huimei , Wang Wenjie
Published: November 2022

Background: Biodiversity loss may seriously impact essential ecological functions, such as nutrient cycling. How litter diversity affects soil carbon and nitrogen cycles in high-latitude forests in northeast China remains unknown.
Methods: We collected fresh litter from 8 tree species in Northeast China and incubated it with native soils for one year. This experiment included 107 treatments representing four species richness (1, 2, 4, and 8) and different arbuscular mycorrhizal (AM) abundance (0, 25%, 50%, 75%, and 100%). The soil aggregate fractions and the contents of glomalin-related soil protein (GRSP), soil organic carbon (SOC), and total nitrogen (TN) in different aggregate fractions were measured.
Results: The increase in litter species richness and AM abundance promoted SOC and TN accrual in macroaggregates (0.25-2 mm). Meanwhile, the same treatment also increased the proportion of macroaggregates and decreased that of silt and clay (< 0.053 mm). The SOC and TN accrual were accompanied by the increase of easily extractable GRSP (EEG) and total GRSP (TG) in macroaggregates and their decrease in silt and clay. Structure equation modeling revealed that aggregate stability was directly increased by EEG (0.476) and TG (0.276). Litter species richness (0.182), AM (0.321), and TG (0.43) directly promoted the SOC accumulation, while litter species richness (0.338), TG (0.331), and EEG (0.203) increased the TN content in the bulk soil.
Conclusion: This study has proved that macroaggregates and GRSP play vital roles in improving the SOC and TN accrual through the increase of litter species richness and AM abundance.
Bioinformatics-based study of possible genetic mechanisms and potential therapeutic agents for PBC
Authors: CHU ZY , Li shasha , Tan Lin
Published: November 2022

Objectives: Primary biliary cirrhosis (PBC) is an autoimmune disease and there is still no clear conclusion as to its cause. Treatment options for PBC are still unsatisfactory. This study aims to explore the possible molecular mechanisms of PBC through bioinformatics techniques and to speculate on potential drugs.
Methods: Firstly, we selected four keywords related to PBC for the search, filtered out the genes related to them and took the intersection. Then these intersecting genes were annotated and analysed using GO and KEGG databases. Next, we explored the interrelationships between the key genes and screened for the most closely related sets of genes. Finally, the database is searched to identify drugs associated with these genes.
Results: The 52 genes shared by the four keywords were obtained through text mining and analysis. Three of these genes were not linked to other genes, and a core gene cluster comprising 23 genes was filtered out of the remaining 49 genes. Finally, the core gene cluster was used to filter out 36 drugs corresponding to them.
Conclusions: This study identified 23 genes most closely related to PBC and 36 potential therapeutic agents for PBC and their possible pathways of action.
Revisiting microbial diversity in hypersaline microbial mats from Guerrero Negro for a better understanding of methanogenic archaeal communities.
Authors: García-Maldonado José Q. , Latisnere-Barragán Hever , Escobar-Zepeda Alejandra , Cadena Santiago , Ramírez-Arenas Patricia J. , Vázquez-Juárez Ricardo , Maurilia Rojas-Contreras , López-Cortés Alejandro
Published: November 2022

Knowledge regarding the diversity of methanogenic archaeal communities in hypersaline environments is limited because of the lack of efficient cultivation efforts as well as their low abundance and metabolic activities. In this study, we explored the microbial communities in hypersaline microbial mats. Bioinformatic analyses showed significant differences among the archaeal community structures for each studied site. Taxonomic assignment based on 16S rRNA and mcrA gene sequences, as well as metagenomic analysis, corroborated the presence of Methanosarcinales. Furthermore, this study also provides evidence for the presence of Methanobacteriales, Methanomicrobiales, Methanomassiliicoccales, Candidatus Methanofastidiosales, Methanocellales, Methanococcales and Methanopyrales, although some of these were found in extremely low relative abundances. Several mcrA environmental sequences were significantly different from those previously reported and did not match with any known methanogenic archaea, suggesting the presence of specific environmental clusters of methanogenic archaea in Guerrero Negro. Based on functional inference and the detection of specific genes in the metagenome, we hypothesised that all four methanogenic pathways are able to occur in these environments. This study allowed the detection of extremely low-abundance methanogenic archaea, which are highly diverse and with unknown physiology, evidencing the presence of all methanogenic metabolisms rather than the sheer existence of exclusively methylotrophic methanogenic archaea in hypersaline environments.
Combination of FAHP and GIS Techniques in Land Suitability Assessment for Banana Cultivation
Authors: Koca Yakup Kenan , Acar Mert , Turgut Yavuz Şahin
Published: November 2022

Banana is one of the most essential foods in terms of health, as it gives satiety due to their high fiber content and contains various minerals and vitamins. Banana cultivation area has been increasing in recent years due to its more income-generating crop than the unit area. Banana cultivation has increased 10 times in Turkey. A significant part of this increase has been in the city of Adana, which is located in the Mediterranean Region, with favorable climate and land conditions. Banana is partially selective in terms of soil/land characteristics for growing. Therefore, it is of great importance to determine the locations of greenhouses to be established for banana cultivation purposes. This study, it is aimed to determine the greenhouse areas to be established for banana cultivation in Çukurova with the help of the Fuzzy Analytic Hierarchy Process (FAHP) and Geographic Information System (GIS). A soil database prepared at the soil series level was used in the study. The suitable soil series for banana cultivation was determined by considering 4 classes of soil series S1 (Highly suitable), S2 (Moderately suitable), S3 (Marginally suitable), and N (Unsuitable). The results showed that the suitability of the study area for banana cultivation was 17.59% at S1, 40.93% at S2, 25.87% at S3, and 11.80% at N. In addition, according to results, the greenhouses in the region should not be established in areas determined as N and S3, but can be established in areas that were mapped as S1 and S2. The results concluded that the integration of FAHP and GIS techniques is a useful method for accurate assessment of land suitability in planning for banana cultivation.
A blood-based lipid profile associated with hippocampal volume and brain resting state activation observed in obese adults from the UK Biobank
Authors: Jiang Guocheng , Rabin Jennifer , Black Sandra , Swardfager Walter , MacIntosh Bradly
Published: November 2022

Background/ObjectivesObesity is associated with functional and structural brain alterations. Less is known about the mechanisms behind such associations. This study investigates whether hippocampus volume and resting state function are associated with a dyslipidemia profile based on high-density lipoprotein, low-density lipoprotein, and triglyceride levels within obese and non-obese adults. A whole-brain analysis was also conducted to examine the effect of dyslipidemia on resting state function across the brain.Subjects/MethodsA total of 554 UK Biobank participants comprised three groups based on body mass index (BMI) rankings: adults with obesity with a higher ranked BMI (OHigh, n=185, ), a second obese group with a lower ranked BMI (OLow, n=182, ), and non-obese controls (n=187). T1-weighted magnetic resonance imaging (MRI) and functional MRI (fMRI) data were accessed. The fMRI data were reconstructed as the fractional amplitude of low-frequency fluctuations (fALFF) maps to reflect resting-state brain activity. A lipid health score was created using principal component analysis. Linear models tested for associations between the lipid health score and hippocampal volume/fALFF, accounting for age, sex, hemoglobin A1c, total grey matter, and white matter volume.ResultsWith a higher lipid health factor corresponding to a lower dyslipidemia risk, we observed a positive correlation between hippocampal volume with the lipid health factor exclusively in group OLow(P=0.01). Meanwhile, we found a positive association between the lipid health factor and hippocampal fALFF in group OHigh(P=0.02). Additional whole brain voxel-wise analysis to group OHighalso implicated the premotor cortex, amygdala, thalamus, subcallosal cortex, temporal fusiform cortex, and middle temporal gyrus brain regions.ConclusionThis study examined three distinct and well-matched groups and highlighted associations between lipids and regional brain volume/resting state function with a primary focus on the hippocampus. These findings support the obesity and brain literature with novel findings regarding the sub-group anthropomorphic differences.
Hypocaloric versus normocaloric nutrition in critically ill patients: a real-world study of a large database MIMIC-IV.
Authors: Li Shuhe , Ma Huan , Tang Yao , Song Xiaodong , Lui Ka Yin , Xu Jinghong , Guo Zilu , Cai Changjie
Published: November 2022

Background
Nutritional therapy is essential for patients in the intensive care unit (ICU), when optimal caloric goals remain controversial, especially for the late acute phase (after day 3). This study aimed to investigate the impact of hypocaloric versus normocaloric feeding in this period.
Methods
We conducted a retrospective analysis within an up-to-date large database, including adult patients who were admitted to a tertiary hospital from 2008 to 2019, and stayed in the ICU for over one week. Individuals were divided according to the mean daily caloric intake from day 4 to day 7 (< 20 Kcal/kg/d; >= 20 Kcal/kg/d). The restricted cubic spline for a cox proportional hazards model was employed to assess the association between mean caloric intake divided by predicted energy expenditure (EE) and 1-year mortality.
Results
3,545 eligible patients formed the study population. Most patients received progressively-elevating nutrition, achieving median values of 18.4 Kcal/kg/d and 0.71 g/kg/d in caloric and protein intake from day 4 onwards. Hypocaloric feeding was correlated with reduced nosocomial infection (41.7% vs 46.7%, P = 0.003), hyperglycemia episodes (63.6% vs 67.8%, P = 0.008), ventilation durations (3.6 vs 4.1 days, P = 0.001), and ICU length of stay (LOS) (11.6 vs 13.4 days, P < 0.001) compared to normal energy provision. In-hospital and 1-year mortality risks displayed no significant changes between the two strategies (ORs [95% CIs]: 0.80 [0.61–1.04], P = 0.10; 0.81 [0.64–1.02], P = 0.08, respectively). Achieving a calorie/EE of 40 ~ 70% showed a great 1-year survival benefit when predicted equations were used.
Conclusion
Compared to normocaloric feeding after day 3, hypocaloric feeding significantly reduced nosocomial infection rate, hyperglycemia episodes, ventilation days, and ICU LOS, when no significant changes were observed in the hospital and 1-year mortality risks. The optimal goal might be set at 40 ~ 70% of EE when predicted equations were used to prevent overfeeding.
Incorporating Multi-hypotheses as Soft-Templates in Neural Headline Generation
Authors: A Yana , Bu Fanyu , Dong Suyalatu
Published: November 2022

Neural models are widely being applied to headline generation. Template-based methods are one promising direction to overcome the shortcomings of the neural headline generation (NHG) model in generating duplicate or extra words. Previous work often retrieves related headlines from the training data and adopts them as the soft template. In this paper, we propose an alternative approach: we exploit the NHG model uncertainty to generate multiple diverse hypotheses and use these as soft-template to improve the model performance. Due to the computation resource limitation, we train our models on Alibaba Cloud, which is one of the largest public cloud providers in the world and operates in various countries. Experiments on English headline generation tasks show that incorporating multi-hypotheses as soft templates provides a significant performance boost over the strong baselines.
Effect of gravity shear ratio on governing failure mode of reinforced concrete slab-column connections
Authors: Jafarian Navid , Mostofinejad Davood , Raji Ali
Published: November 2022

Reinforced concrete (RC) flat slabs are widely being applied to almost every building structure due to their distinct advantages. Nevertheless, there has not yet been a definitive method to precisely foresee the governing slab failure modes. This research was targeted at predicting the main failure mode of RC slab-column connections subjected to unbalanced moment and various vertical shear forces, for the first time. Thus, the failure modes of the connections were deviated by comparing the unbalanced moment capacity at punching shear failure controlled by the codes and unbalanced moment strength at the flexural mechanism checked by the yield line theory (YLT). The procedure was validated by the results of experimental tests carried out at authentic research in the literature. Afterward, 200 case studies were done on the connections under moment transfer at 20%, 40%, and 60% of gravity shear ratios (GSRs), regarding the alteration of flexural reinforcement ratio from zero to 3.0%. Openings and shear strengthening were looked into in the case studies as two highly effective parameters for the governing failure mode. The intersection of unbalanced moment capacities owing to punching shear and flexural collapses with respect to the longitudinal reinforcement ratio indicated the coordinate of boundary point (BP) between possible failure modes. It was proved that the GSR rise and the existence of opening, lead to a decline in the coordinate of BP notwithstanding, the effect of shear strengthening was in reverse.
Compare three diagnostic criteria of progressive pulmonary fibrosis
Authors: Tao Chen , Chunfang Zeng
Published: November 2022

Background and objective: In patients with fibrotic interstitial lung disease (ILD), a progressive fibrosing phenotype (PPF) typically demonstrates worsening respiratory symptoms, lung function decline and continuing fibrosis. The goal of this study was to compare the three different diagnostic criteria of PPF.
Methods: Except for idiopathic pulmonary fibrosis, all consecutive adult patients with fibrotic ILD were retrospectively examined for the three predefined diagnostic criteria of PPF. The three criteria assess the disease progression in preceding 6 (half-year), 12 (one-year) and 24 (two-year) months respectively. The clinical characteristics, decline in predicted percent of forced vital capacity (FVC%) and survival of the three groups were compared, followed by determination of risk factors for mortality.
Results: We identified 246 patients by half-year standard, 154 patients by one-year standard and 281 patients by two-year standard. Among them, 95% of patients in one-year group were also included in two-year group. The average one-year decline in FVC% was -1.0%, -2.7%, and -4.1% for half-year, one-year and two-year group respectively. The 4-year survival rate was 74% in half-year group, 66% in one-year group and 62% in two-year group. In multivariate Cox model, only baseline DLCO%<50% was correlated with mortality, with a hazard ratio of 3.4 (95% CI 1.1-10.6, P=0.03).
Conclusion: In the current situations, both the one-year and two-year criterion are the reasonable choice to define PPF both in researches and clinical practice, and DLCO% is an independent predictor for mortality of PPF.
Coronary Hemodynamic Simulation Study
Authors: Yang Fengyuan , Chen Zhenlei , Zheng Rongyue , He Wenming , Shi Fan , Liu Chang , Wang Li , Xie Yanqing , Lu Haoxuan , Cheng Leilei
Published: November 2022

In this paper, a two-way fluid-structure coupling model is developed to simulate and analyze the hemodynamic process based on dynamic coronary angiography, and examine the influence of different hemodynamic parameters on coronary arteries in typical coronary stenosis lesions. Using the measured FFR pressure data of a patient, the pressure-time function curve is fitted to ensure the accuracy of the boundary conditions. The average error of the simulation pressure results compared to the test data is 6.74%. In addition, the results related to blood flow, pressure contour and wall shear stress contour in a typical cardiac cycle are obtained by simulation analysis. These results are found to be in good agreement with the laws of the real cardiac cycle, which verifies the rationality of the simulation. In conclusion, based on the modeling and hemodynamic simulation analysis process of dynamic coronary angiography, this paper proposes a method to assist the analysis and evaluation of coronary hemodynamic and functional parameters, which has certain practical significance.
Flood hazards characterization using multi-criteria decision and flood frequency analysis in Osun River Basin, Nigeria
Authors: Komolafe Akinola Adesuji , Olorunfemi. Idowu Ezekiel , Ogbueze Christopher Chima , Popoola Olusola O.
Published: November 2022

Flooding is regarded as one of the world's most dangerous natural disasters with great highly devastating social, economic and environmental impacts. This study employs the use of a GIS-based multi-criteria decision approach (MCDA) and flood frequency analysis to assess the flood potential zones and magnitudes in the Osun River basin. Six flood causative factors (soil type, elevation, slope, drainage density, distance from the river, land use land cover) were considered and integrated into the Geographical Information System using analytical hierarchy process (AHP) and weighted overlay with a consistency ratio of 0.04. The output was classified as having a flood potential ranging from very low to very high. HEC-HMS hydrological model was used to simulate previous potential flood discharges from 1981 to 2020 within the river basin. A basic descriptive analysis was performed to understand the hydrological characteristics of the basin from the previous records. We analysed the flood frequency from the simulated stream peak flow using the Gumbel frequency distribution method. The results from the analysis showed that 11% of the study area is highly prone to flooding. The moderately prone zones cover more area (82%) and 7% of the area is not prone to flooding. The peak discharge for the simulation period ranged from 531.5 to 1846.8 m3/s. The peak discharge (1846.8 m3/s) at the basin has a 41-year recurrence interval. Using the Gumbel’s extreme value distribution method, the calculated discharge flood lies within 1117.43 m3/sec to 1858.51 m3/sec for 5 years to 150 years’ return period for the Osun River basin
Study on edge breakage of optical glass surface in ultrasonic vibration-assisted milling
Authors: Tong Jinglin , Yang Shuaikun , Ye Yanqiu , Zhang Zhipeng , Song Chaosheng , Wang Xiaobo
Published: November 2022

Optical glass is an isotropic amorphous solid material, due to its excellent performance, it has been widely used in various fields. However, during the milling process, the optical glass will have defects such as chipping and cracks on the surface, import and export, and side edges, these defects seriously affect the application of optical glass. In order to study the formation mechanism of defects such as chipping and cracks during optical glass processing, experimental and theoretical study of optical glass milling using ultrasonic vibration-assisted milling (UVAM), the chipping depth model of the export edge collapse was established. The results show that, the main reason for the edge chipping defect is that the optical glass will crack on the subsurface during processing, the propagation of these cracks causes the matrix material to tear and crumble. By comparing and analyzing the results of ultrasonic vibration milling and ordinary milling, ultrasonic vibration can significantly reduce this phenomenon, and it is found that the cutting depth and feed per tooth have a great influence on the export chipping depth value, and the influence of spindle speed is less. In addition, when the amplitude of the ultrasonic wave is applied, not only the import and export edge chipping phenomenon can be significantly improved, but also the surface quality can be significantly improved. Therefore, the application of ultrasonic vibration-assisted milling to the processing of optical glass can improve the surface and edge quality, which is help improve the application range of optical glass.
Acute myeloid leukemia among patients at the National Oncology Center in Sana ’ a, Yemen: prevalence, subtypes, and hematological features
Authors: Al-Nuzaili Mohammed Abdulkader , Al-Khamesy Khaled Saad , Yahia Osama Muzher
Published: November 2022

Background
Acute myeloid leukemia (AML) is a malignant disorder of the myeloid cell lineage within the bone marrow (BM). It is caused by chromosomal abnormalities resulting in the accumulation of myeloblasts within the BM and infiltration of peripheral tissues. The aim of this study was to determine the prevalence, subtypes, and hematological features of AML among patients at the National Oncology Center (NOC) in Sana'a.
Methods
This retrospectively registered study was carried out on 747 patients diagnosed with hematological malignancies (HMs). It included 472 (63.2%) males and 275 (36.8%) females, aged 1 to 75 years. The registered data was collected from the NOC in Sana'a, Yemen, between March 2020 and May 2022. These patients came to the NOC from different hospitals and clinics in Sana’a as well as from other governorates. The patients came to NOC for a better diagnosis and appropriate treatment. The diagnosis of AML was performed by CBC, Giemsa-stained blood/BM films, and immunophenotypic using flow cytometry to confirm, if necessary, the definitive diagnosis. The SPSS-26 program was used to analyze the data.
Results
Among 747 patients, there were 175 (23.4%) patients diagnosed with AML. It included 98 (56%) males and 77 (44%) females, ages 1 to 75. Acute leukemia (ALL and AML) and chronic leukemia (CML and CLL) were detected in 543 (79.7%) and 138 (20.3%) patients, respectively. The relative frequencies of leukemia were ALL, AML, CML, and CLL, which were detected in 49.30%, 23.43%, 11.65%, and 6.83% of patients, respectively. FAB-M2 was observed in 48.57% of patients, followed by M5 (17.72%), M1 (15.43%), M3 (11.43%), M4 (5.71%), and the less common M0 (0.57%), M7 (0.57%), and M6 (0%). The hematological features in AML patients include decreased Hb, increased WBC, and decreased platelets in 96.6%, 81.7%, and 100% of patients, respectively. There were significant positive correlations between age and Hb (p = 0.009) and WBC (p = 0.002), and between Hb and WBC (p = 0.001).
Conclusion
Leukemia was the most common type among hematological malignancies (HMs). ALL and AML constitute approximately a half and a quarter of leukemia. AML-M2 was the most common FAB subtype in half of the AML patients.
Evaluation of the effectiveness of nano-hydroxyapatite particles in wound healing in an animal study
Authors: Lalehzar Sahar sadat , Meamar Rokhsareh , Talebi Ardeshir , Fesharaki Mehrafarin
Published: November 2022

Background

The main activity of the skin is to create a protective barrier against damage. Loss of the skin due to injury or disease and failure to regenerate the affected area may result in disability, infection, or even death. We conducted the animal study to Evaluation of the effectiveness of nano-hydroxyapatite particles in wound healing.

Method

This animal study performed in Isfahan university of medical science animal lab. Experiments were performed on 30 Wistar in 5 groups. Biopsies 5×5mm were obtain of abdominal, and were transferred to the cell culture laboratory into the phosphate buffer saline (PBS). The cell proliferation was determined using the colorimetric MTS assay. The type and approach of this animal study is to create a deep skin wound and try to treat the wound with drug (nano_ hydroxyapatite 10%, nano_hydroxyapatite40%, combination of Nickle ion with nanohydroxyapatite 10%, and 40%) intervention on an animal model of rat. Macroscopic evaluation and pathological examination were done. For pathological and histological examination of the wound, sampling was done on the seventh and fourteenth days after ulcer induction. All continuous and categorical data are presented as mean ± standard deviation (SD) and frequency (percentage), respectively. Paired sample T-test and repeated measure analysis of variance (ANOVA), Chi-squared test was used.

Results

During this study, MTS assay was carried out to evaluate the proliferation of mice fibroblast on the gelatin without hydroxyapatite, and with 10, 40% hydroxyapatite after1, 2 and 3 days of culture. significant enhancement of cell proliferation was observed in nano HA 10, 40% and nano HA 10% with nickel in comparison when the cells seeded on gelatin and HA 10%. The best result was shown in 24 hours after seeding the cells in gelatin in comparison with 48, and 72 hours. Indeed, after 48 and 72 hours, the cell proliferation on gelatin decreased. In evaluation of Wound area with image j soft ward, the wound area between day 3,7 and 14 of treatment after wound induction there were no significant difference between groups. In microscopic study and analysis for evaluation and comparing wound length with the Michrome camera and Mosaic soft ward, there were no significant relation in time (p1 = 0.77). There is a difference is close to significant between the groups(p2 = 0.065). There was no significant difference between time and group(p3 = 0.323). In day 14 the wound length between groups had significant difference(p4 = 0.049).

Conclusion

In conclusion, hydroxyapatites and its combination with Nickle ion have significant effect on wound healing and cell proliferation.
Parkinson’s mimicker in Acute and Chronic Hepatic Encephalopathy
Authors: Setia Mohamad Shahrunizam Awang , Ros Mohamad Izzat Arslan Che , Rahim Nurul Hafidzah , Ismail Nik Azuan Nik
Published: November 2022

Hepatic encephalopathy is a neuropsychiatric spectrum, mainly caused by cirrhosis, portosystemic shunt, or portal hypertension. It is associated with poor survival and high recurrence rate without prompt initiation of adequate treatment. MRI can detect the extent of brain parenchymal injury and correlation to the patients’ clinical status is the utmost importance. Here we report a case of 42 years old man with underlying hepatitis C, with atypical presentation of parkinsonism in a classic MRI imaging findings of acute on chronic hepatic encephalopathy.
Feedback on the Preceptor's Experience Post-training: “A Quasi-experimental Design”
Authors: Dorgham Shereen R. , Alfaraj Eshtiaq , Al-Mahmoud Sana A.
Published: November 2022

Background:

The conventional clinical practice component of undergraduate nursing education is insufficient preparation for contemporary professional nursing practice. The preceptorship program became a substitute for limited clinical training in nursing school. Few studies have been conducted to demonstrate its practice impact above that of conventional clinical training. Therefore, the preparation of nurse preceptors is vital to any of the preceptorship roles. The preceptor plays a significant role during the transition period from being a student to a competent nurse. He/she provides direct supervision, support, and guidance, and offers a role model to consolidate scientific knowledge, practice clinical skills, and develop professional attitudes and values.

Objective:

The objective of the study is to assess differences between the preceptors' knowledge pre- and post-training program, evaluate preceptor’s feedback regarding the training program, assess the effect of the training program on preceptor’s performance three months post-training, and evaluate student’s satisfaction with the preceptor’s performance three months post-training.

Method:

A quasi-experimental design was adopted in this study. Overall, there were 79 (n=34 Saudi and non-Saudi nurse demonstrators and lecturers who have working experience of at least six months and n=45 nurse students) study participants. Questionnaires were used to collect data.

Results:

A statistically significant difference was found between pre-test and post-test values of nurse demonstrators and lecturers' awareness of preceptorship.

Conclusion:

Participants perceived the preceptorship program positively as they learned to assume different roles as a preceptor, an educator, a facilitator, a role model, and an evaluator.

The preceptorship program focuses on essential skills pertinent to clinical and educational settings. It develops clinical preceptors' roles and helps them support, develop and integrate new graduate nurses' clinical competence using an individualized and systematic approach. The ultimate aim is to ensure patient safety, i.e., the preceptee masters the clinical skills needed for competence before moving into more advanced nursing care tasks.
Novo ano, novos rumos
Authors: Moita Edvaldo , Stamford da Silva Artur
Published: November 2022

Apresentação do volume 9, número 1, ano 2022, da Revista Brasileira de Sociologia do Direito.
Sistema de justiça criminal brasileiro e o racismo institucional
Authors: Miguel Batista Waleska , Silva Santos Julio Cesar , Nascimento dos Santos Lídia Carolina , Rodrigues da Silva Ariella Luiza
Published: November 2022

Neste artigo, apresenta-se o sistema de justiça criminal como um instrumento de inferiorização da população negra, que é o grupo-alvo da seletividade penal de forma naturalizada e normalizada, e sua utilização para a manutenção da discriminação racial enraizada no Estado brasileiro. A partir da análise dos casos Marielle Franco, Bárbara Quirino de Oliveira, dentre outros, nota-se que as instituições do sistema de justiça criminal brasileiro definem a população negra como criminosa antes da prolação de uma sentença condenatória nos casos concretos. Por fim, conclui-se que as leis antirracistas não têm sido suficientes para alterar essa realidade, que é evidenciada em diversas situações.