bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical Modeling of Microbial Community Dynamics
Authors: Paredes Ana , Balsa-Canto Eva , R. Banga Julio
Published: February 2025

Microbial communities act as complex ecological networks, crucial in diverse natural and engineered settings. These communities consist of bacteria, fungi, viruses, and other microorganisms that interact with one another and their environment. They perform essential functions such as nutrient cycling, degradation of pollutants, and maintaining the health of plants, animals, and humans.
Systems biology leverages mathematical models to study these communities in a systematic and quantitative manner. Our work concentrates on calibrating nonlinear models in Ordinary Differential Equations (ODEs), evaluating both structural and practical identifiability properties to verify if model parameters can be uniquely estimated from the available data.
This is crucial to ensure model reliability, enhancing our understanding of how microbial ecosystems work, and providing us with tools for optimal design and management of microbial ecosystems for applications in health and environmental science.
Advancing Machine Learning with Distributed and Edge Computing
Authors: Tomé-Moure Rubén , Morán-Fernández Laura , Bolón-Canedo Verónica
Published: February 2025

The amount of data used by modern machine learning algorithms is increasing, which presents several challenges. First and foremost, the data does not come from a single repository, but is distributed across multiple sources, often in different geographic locations. Another challenge is the high hardware requirements needed to process the data, which can be prohibitively expensive. The proposed approach allows a classifier to run in a distributed environment, simulating a real-world scenario where each node is as close to the data as possible, eliminating the need for a single data source. Furthermore, distributing the computational load of classification across multiple machines can be beneficial in an Internet of Things environment, avoiding the need to purchase expensive equipment.
ATENDIS-VR: Virtual Reality Application Adapted for Older Adults and Individuals with Intellectual Disabilities
Authors: Groba Betania , Concheiro-Moscoso Patricia , Gómez Ángel , Lagos Rodríguez Manuel , Miranda-Duro María del Carmen , Fernández-Garrido Iago
Published: February 2025

The recent advances in virtual reality allow for the creation of highly realistic and immersive environments. The purpose of this project is to develop a virtual reality application tailored for older adults and people with intellectual disabilities to work on various physical and cognitive aspects through gamification. This tool features seven activities with adjustable difficulty levels and accessibility options, providing users with an engaging and personalized experience to enhance cognitive, physical abilities, and mental agility.
Acuerdo de paz con las FARC y proceso de justicia transicional en Colombia: Derechos a la verdad y a la justicia
Authors: Torres Mora Álvaro Germán
Published: February 2025

Este artículo aborda los contenidos y resultados del proceso de justicia transicional pactado en el acuerdo de paz con las Fuerzas Armadas Revolucionarias de Colombia (FARC) para determinar si este satisface los derechos a la verdad y a la justicia, y hasta qué punto lo hace. Para el efecto se estudian los orígenes del conflicto y se analizan otras experiencias de justicia transicional, buscando definir la naturaleza del proceso colombiano y sus diferencias respecto de experiencias anteriores, teniendo como base una metodología de derecho comparado que busca contrastar instituciones y marcos jurídicos. El estudio sirvió para determinar que el caso colombiano satisface los derechos a la justicia y a la verdad se aproxima más a los modelos basados en la memoria y la retribución que a los de perdón y olvido, considerando el fuerte énfasis en la creación de una comisión de la verdad, el condicionamiento de las sanciones alternativas a las confesiones, la ausencia de amnistías generales y las sanciones restrictivas de la libertad por delitos graves. Esta investigación contribuye en la comprensión del conflicto armado y de la justicia transicional en Colombia acordada en el proceso de paz con las FARC. El caso colombiano puede servir de modelo a procesos de justicia transicional surgidos en el marco de conflictos activos, a través de mecanismos de retribución moderada basados en la imposición de sanciones alternativas que permitan asegurar la garantía del derecho a la verdad y conservando la posibilidad de aplicar sanciones ordinarias cuando dicha garantía no se satisfaga.
The Role of Perceived Ease of Use, Perceived Usefulness, Attitude Towards Using, and Compatibility on E-Money Usage Intention: Study At Jombang, Indonesia
Authors: Nadia Kinanti Jasmine , Tambunan Damelina Basauli , Yuniriyanti Eny
Published: February 2025

This study aims at testing and analyzing the influence of perceived ease of use, perceived usefulness, and attitude towards using on behavioral intention to use e money and moderated by compatibility. The population of this study is customers from a café in Jombang, Indonesia. Purposive sampling is the sampling technique used in this study, with the criteria Navila Café & Resto Jombang’s customers who directly visited during the study. This study uses physical questionnaire to collect data. The total number of respondents is 113 people. This study uses SEM-PLS as data analysis technique, while the analysis tool is Smart PLS 4. The finding of this study reveals, first, perceived ease of use gives positive significant influence towards perceived usefulness. Second, perceived ease of use gives positive significant influence towards attitude towards using. Third, perceived usefulness gives positive significant influence towards attitude towards using. Fourth, perceived usefulness has complementary mediation effect between perceived ease of use and attitude towards using. Fifth, attitude towards using gives positive significant influence towards behavioral intention to use. Sixth, compatibility doesn’t have moderation effect between attitude towards using and behavioral intention to use.
Środowisko zgierskiej haskali w świetle Sefer Zgierz, Mazkeretnetsach Le-Kehilayehudit Be-Polin
Authors: Kucner Monika , Gołaszewski Marcin
Published: February 2025

The Haskalah, as an intellectual movement among Jews, was a reformist trend of the late 18th century. In Zgierz, it only emerged in the 1860s. Its goal was to promote a new cultural ideal of the Jew as someone well-versed in the Torah while simultaneously integrating into the local community. Education, combating Jewish separatism, preserving identity, culture, and the Hebrew language, as well as the languages of local communities, were key tasks undertaken by the maskilim. Jewish Enlightenment was also manifested through active involvement in local government institutions, interactions with the Christian population, literary and journalistic activities. The following article attempts to outline the specific characteristics of this phenomenon in Zgierz, depicting its history, significance, and development.
Motyw władzy w dramacie Bum Mariusa von Mayenburga
Authors: Janowska Aleksandra
Published: February 2025

Power is the main theme of the play Bang, which polish premiered in 2019 and took place at the New Theater of Kazimierz Dejmek in Łódź. The play was directed based on the drama of the same title, written by the contemporary German author and playwright Marius von Mayenburg. The aim of the article is to analyze and describe the means by which the viewer has the opportunity to understand why the theme of power is highlighted against the background of others presented in the play and to answer the question of what is the reason for the main character Ralf Bang’s desire to exercise power even before his own birth.
Hrp proteins as bioinducers for the biocontrol of bacterial diseases in tomato and pepper plants in greenhouse
Authors: Cuellar-Espejel María del Sol , Quiñones-Aguilar Evangelina Esmeralda , Rincón-Enríquez Gabriel , Hernández-Gutiérrez Rodolfo , Mateos-Díaz Juan Carlos , Valerio-Landa Sergio David
Published: February 2025

Background/Objective. Diseases such as bacterial spot in tomato (Solanum lycopersicum) and bacterial spot in chili pepper (Capsicum annuum) cause significant global economic losses. A sustainable alternative for their control is the use of protein inducers (Harpin proteins = Hrp) that activate plant defense responses by being recognized by the plant immune system, inducing defense mechanisms against pathogens. The objective of this research was to evaluate the biological effectiveness and optimal application dose of the biological inducer BioFensa (based on Hrp proteins), produced in a pilot plant, to control these diseases. Materials and Methods. Three greenhouse experiments were conducted to evaluate the biological effectiveness of BioFensa (1 μg mL⁻¹). The protein inducer was tested for controlling bacterial spot (X. euvesicatoria strain BV865 [1] and BV801 [2]), as well as bacterial speck (P. syringae pv. tomato, strain DC3000 [3]). Each experiment included 5 treatments and 11 replicates. Additionally, an experiment was conducted to determine the optimal dose of BioFensa (0.01, 0.1, and 1.0 μg mL⁻¹) against X. euvesicatoria strain BV801, with 7 treatments and 8 replicates [4]. In the four experiments in total, plants were sprayed with BioFensa (3 mL per plant) 24 hours before infection, and symptoms were evaluated after 30 days by counting spots on the foliar tissue. Results. BioFensa was effective in significantly reducing damage in chili and tomato plants (LSD, p≤0.05). At a high concentration (1 μg mL⁻¹), it prevented the appearance of spots on tomato plants by 53%, while for chili plants against strain BV865, it prevented spots by 60%. On the other hand, for chili plants against strain BV801, at low concentrations (0.01 and 0.1 μg mL⁻¹), symptoms were significantly reduced by 38-41%, whereas at a higher concentration (1 μg mL⁻¹), this effect was not maintained, suggesting a limit in the perception of inducers by the plants. Conclusion. The results suggest that BioFensa has the potential to be an effective alternative to control diseases in horticultural crops such as tomatoes and chili peppers.
A propos des bois de rose de Madagascar
Authors: Normand Didier
Published: February 2025

Le terme français « Bois de rose » désigne souvent d'autres bois que le palissandre brésilien utilisé au XVIIIe siècle par les ébénistes. Il existe un peu partout des bois ainsi qualifiés parce qu'ils ont la particularité d'exhaler plus ou moins discrètement un parfum de rose. Les bois de rose de Madagascar ressemblent à l'ébène du Mozambique ou du Sénégal. Ces bois de rose deviennent très foncés en vieillissant.Dans cet article, l'auteur fournit une clé pour décrire les caractéristiques de chacune des trois espèces qui, selon lui, se trouvent le long du littoral de la côte est de Madagascar. Une analyse du bois est ensuite proposée.
FACTORS RELATED TO COMPLIANCE WITH DIET MANAGEMENT AMONG TYPE 2 DM OUTPATIENTS IN ROYAL PRIMA HOSPITAL
Authors: Ginting Rapael , Simanullang Andry , Siallagan Gabriel Oktavianus
Published: February 2025

Background: Diabetes mellitus in Indonesia is increasing annually, with a 6.7% death rate. This is due to patients not following the recommended diet, with Type 2 DM patients having minimal dietary compliance... Purpose: This study aims to find out the relationship between age, gender, education, knowledge, employment status, family role, and the support of health officials to comply with the diet of outpatients type 2 DM in Royal Prima Medan Hospital. Methods: This research method uses cross-sectional methods of conducting interviews, observations, and questionnaire filling. Data were analyzed by using the SPSS application with the α=5% Chi-Square test and the samples used in this study were patients with outpatients type 2 DM at RSU. Royal Prima Medan Hospital with a total of 64 patients in 2024. Results: The result, it was found that there was a significant relationship between age (OR:0.03, CI 95%: 1.67-15.17), gender (OR:0.01, CI 95%:1.28-10.14), knowledge (OR:0.02, CI 95%:0.10-0.89), family role (OR:0.05, CI 95%:0.06-0.64), and health support (OR:0.01, CI 95%:0.05-0.49) for compliance with the outpatients type 2 DM diet management. But there is no significant relationship between education (OR:0.63, CI 95%:0.29-2.11) and job status (OR:0.79, CI 95%:0.42-3.05) for conformity to the type 2 DM diet. Conclusion: This study found that the variable age was the most dominant risk factor for diet management type 2 DM with an OR of 18.935 with p-value (0.04).
RISK FACTORS OF HYPERTENSION IN PREGNANT WOMEN IN LABUHANBATU REGENCY: A CROSS−SECTIONAL STUDY
Authors: Hartono Hartono , Manalu Putranto , Janas Dhyta Nurhasanah , Siagian Masryna , Nadapdap Marshall Jeremia
Published: February 2025

Background: Pregnant women with hypertension face elevated risks of complications, including preeclampsia and maternal mortality. Despite the increasing prevalence of gestational hypertension and its associated burdens, limited research—particularly at the local level—hinders effective prevention and management strategies. Purpose: This research aimed to investigate the risk factors associated with hypertension in pregnant women in Labuhan Batu Regency. Methods: This cross-sectional study involved 80 pregnant women from Labuhanbatu Regency, North Sumatra, Indonesia. Data on obesity, age, physical activity, and secondhand smoke exposure were collected through measurements and questionnaires. Obesity was assessed using mid-upper arm circumference (MUAC), while other variables were determined through interviews. Data were analyzed descriptively, and Fisher’s exact test was employed to compare risk factors between hypertensive and non-hypertensive pregnant women. Results: Obesity (p=0.29) and age (p=0.84) were not significantly associated with hypertension. However, pregnant women with light physical activity had a lower risk of hypertension compared to those with heavy physical activity (p=0.02). There was no significant association between exposure to cigarette smoke and hypertension (p=0.20). Conclusion: The findings suggest that light physical activity might be protective against hypertension during pregnancy among homemakers in Labuhanbatu regency.
The Impact of Workplace Dust Exposure and Mask Usage on Pulmonary Function in Construction Environments
Authors: Sumardiyono Sumardiyono , Maria Paskanita Widjanarti  , Farhana Syahrotun Nisa Suratna  , Bachtiar Chahyadhi  , Reni Wijayanti  , Rachmawati Prihantina Fauzi  , Yeremia Rante Ada’  , Yunita Dwi Puspitasari  , Agathara Reidiatama Aviano
Published: February 2025

Introduction: The chance of respiratory diseases among workers participating in toll road construction projects is, for example, higher because of non-organic dust. Therefore, this study aims to evaluate the level of lung capacity experienced by the workers by exposing them to dust and wearing masks. Methods: This cross-sectional study investigated toll road projects in Central Java and Yogyakarta and randomly selected workers from different strata of construction companies. The volume Air Sampler estimated dust concentration, while the pulmonary function test included spirometry. All data were analyzed using two-way MANOVA. Results and Discussion: The multivariate analysis of variance showed that workers exposed to dust exceeding the Threshold Limit Value (TLV) had significantly reduced FEV1 and FVC averages (p < 0.001). The averages of FEV1 and FVC increased more considerably in mask users than non-users, indicating mask usage's benefits. The decline in lung function was smaller in mask users, with FEV1 (95% CI: 0.080–0.321) and FVC (95% CI: 0.071–0.404). A reduction in walking distance also demonstrated significance to the decrease in FVC. Conclusion: They found that dust in construction declines lung capacity, but wearing masks provides some protection. However, such impact continues even after stopping wearing masks, thus stressing the importance of correct mask usage and staff training. Subsequent research must investigate dust interaction and various types of masks to enhance Indonesian workers’ health.
High Blood Lead Levels as A Risk Factor of Stunting: A Study of Children in Agricultural Areas
Authors: Afandi Alfan , Suhartono Suhartono , Budiyono Budiyono , Margawati Ani , Kartini Apoina
Published: February 2025

Introduction: The prevalence of stunting among student aged children in Indonesia is relatively high (24.5%). Stunting can threaten the quality of human resources one day. Lead exposure, particularly from pesticides, is thought to disrupt children's development and growth. This study aims to demonstrate that high blood lead levels (BLL) is a risk factor of stunting for children who lives in agricultural areas through the intermediate variable, namely interference with growth hormone (IGF-1). Methods: This study used a case-control design, involving 35 cases (children with HAZ scores of less than -2 SD) and 40 controls (children with HAZ scores of more than -1.5 SD). BLL were measured using the atomic absorption spectrophotometer (AAS) method. Meanwhile, insulin-like growth factor-1 (IGF-1) levels using an ELISA kit (R&D Systems). BLL variables and IGF-1 levels were determined using the receiver operating characteristic (ROC) curve. Results and Discussion: High BLL (>20.44 μg/dL) and low IGF-1 levels (<100 ng/ml) were identified risk factors for stunting in children in agricultural areas with odd ratios (OR) od 2.8 (1.1-7.1) and 3.3 (1.3-8.5) respectively. Meanwhile, a negative correlation was discovered between BLL and IGF-1 levels (p = 0.002, r = -0.356). Conclusion: High lead exposure has been proven to be a risk factor for stunting in children in agricultural areas through the process of interference with the growth hormone, namely IGF-1. Efforts to prevent stunting, especially in agricultural areas, need to take into account exposure to environmental toxicants, including lead from pesticides.
Comparison of Chronic Heavy Metal Contamination Level in the Body Between Chemical Pesticide Sprayers and General Public Around Agricultural Areas
Authors: Renaningtyas Nityasani  , Khuliyah Candraning Diyanah  , Wicaksono Rania Ichwana , Muhammad Azmi Maruf  , Zainul Amiruddin Zakaria  , Aditya Sukma Pawitra
Published: February 2025

Introduction: The increasing use of chemical pesticides in agriculture raises concerns about heavy metal exposure. This study compares chronic heavy metal contamination levels (Pb, Cd, Cr6+) in the urine of pesticide sprayers and the general public in agricultural areas. Methods: A cross-sectional study with 100 respondents, equally divided between sprayers and the general public, was conducted. Data were gathered through interviews, observations, and laboratory tests. Heavy metal levels in urine were analyzed using Atomic Absorption Spectroscopy (AAS). Factors like age, work duration, spraying frequency, and Personal Protective Equipment (PPE) use were examined through Mann-Whitney and linear regression tests. Results and Discussion: Pesticide sprayers had significantly higher mean levels of Pb (0.084 mg/kg), Cd (0.010 mg/kg), and Cr6+ (0.010 mg/kg) than the general public. Key contributors to this accumulation included age, working hours, and the number of pesticide mixtures used. Inadequate PPE use and long exposure times were common, leading to health complaints such as nausea, vomiting, and headaches, indicating the harmful effects of pesticide exposure. Conclusion: Pesticide sprayers are at greater risk of heavy metal accumulation due to prolonged exposure and poor safety measures. Improving PPE use and reducing exposure are critical to minimizing health risks from heavy metal contamination. Awareness campaigns are necessary to protect agricultural workers.
Kajian Sifat Fisika Tanah Ultisol Pra dan Pasca Penanaman Padi Sawah
Authors: Rahmadani Muhammad Holqi , Syarbini Muhammad , Saidy Akhmad Rizalli
Published: February 2025

This research is motivated by the conversion of many rice fields in Indonesia for various purposes, such as residential areas, offices, industries, tourism, transportation, and other uses. The environmental change focused on in this study is the conversion of Ultisol land into paddy fields. The aim of the research is to determine the differences in soil physical properties, including grain density, bulk density, soil porosity, permeability, and soil aggregate stability in Ultisol that have been subjected to inundation. The study follows a Completely Randomized Design (CRD) with a single factor. The factor tested is the origin of Ultisol soil taken from five different districts in South Kalimantan. Soil samples represent the distinct districts, and each district is replicated five times. Paired t-test is employed to observe the differences in the physical properties of inundated and non-inundated Ultisol. Incubation and physics analysis are carried out at the Greenhouse of the Soil Department and the Physics, Chemistry, and Biology Laboratory of the Soil Department, Faculty of Agriculture, Lambung Mangkurat University. The results indicate that inundation in Ultisol soil does not significantly affect soil density and soil porosity. Inundation, however, significantly differs in soil bulk density, permeability, and soil aggregate stability. Changes in soil physical properties are not correlated with plant dry weight.
Peranan Eco-Enzyme terhadap Perubahan Hara N Tanah dan Pertumbuhan Awal Padi pada Tanah Sawah Tadah Hujan
Authors: Suwandi Sakti Agrianto , Razie Fakhrur , Hayati Afiah
Published: February 2025

Acid mineral soils in Indonesia mostly develop in wet tropical climates supported by high temperatures, so the weathering process runs faster than in dry climate areas. High rainfall causes intensive leaching, so basic cations are lost from the soil layer, and the soil has low base saturation. Some acid mineral soils in Indonesia are farmed under rainfed systems. This soil has a low nutrient availability status compared to irrigated rice fields, due to the lack of water availability, and is still dependent on rainfall. Eco-Enzyme (EE) contains several nutrients and microbes from fermentation that can increase soil fertility. This research aims to determine the effect of EE N nutrient availability and early rice growth in rainfed paddy fields. This study uses a Completely Randomized Design single factor, namely the total bacterial population in EE consisting of 5 treatments, namely K0= control; K1= 8,1 x 106 cells mL-1 in EE; K2= 1,2 x 107 cells mL-1 in EE; K3= 1,6 x 107 cells mL-1 in EE; and K4= 2 x 107 cells mL-1 in EE. Each treatment was repeated 4 times so that there were 20 experimental units. The results of the study show that the provision of the total bacterial population in EE 1,2 x 107 cells mL-1 can increase the pH to 5,38, N-NH4+ to 154,60 mg kg-1, and N-NO3- to 8,26 mg kg-1. Giving total bacteria in EE 1,6 x 107 cells mL-1 can increase the viability of non-symbiotic N2 fixing microbes.
Endopedon yang Berkembang dari Batuan Ultrabasa di Desa Bentok Darat Kabupaten Tanah Laut, Kalimantan Selatan
Authors: Fahrezal Ahmad , Syaifuddin Syaifuddin , Septiana Meldia
Published: February 2025

Although ultramafic rocks are widespread in Indonesia and have the potential to influence soil properties, studies on the genesis and properties of soils formed from these rocks, especially to understand the characteristics of the lower defining horizon or endopedon, are still limited. This study aims to identify the endopedons formed, which developed from the ultrabasic rocks. This research is descriptive, soil profile points are determined by purposive sampling method by considering that points are true ultrabasic rock distribution. Observations made in this study include observations in the field and observations in the laboratory. The data from the description and laboratory analysis were used as reference for identifying endopedon. Endopedon determination refers to the Keys to Soil Taxonomy 2014 , the twelfth edition. The oxic horizon in Profile-1 is found at a depth of 7 cm to 37 cm from the soil surface with the horizon codes Bo. The Oxic horizon in Profile-2 is located at a depth of 20 cm to 106 cm from the soil surface with the horizon codes Bo1, Bo2. Latosolization is the process that causes the formation of the oxic horizon. The study site is also an area with a wet tropical climate that supports the formation of the oxic horizon.
Kemampuan Pseudomonas Kelompok Fluorescens dalam Meningkatkan Ketahanan Tanaman Tomat Terhadap Infeksi Virus Keriting Kuning
Authors: Halimah Nur , Aidawati Noor , Fitriyanti Dewi
Published: February 2025

Penelitian ini menggunakan Pseudomonas fluorescens yang diduga dapat menghambat populasi penyakit serta dapat menginduksi ketahanan tanaman. Penelitian ini bertujuan untuk mengetahui kemampuan Pseudomonas kelompok fluorescens dalam mengendalikan infeksi virus keriting kuning pada tanaman tomat. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) satu faktor terdiri dari lima, yaitu 3 perlakuan, 1 perlakuan kontrol+ & 1 kontrol, perlakuan diulang 4 kali sehingga berjumlah 20 tanaman. Setiap satuan percobaan berisi 2 tanaman tomat sehingga berjumlah 40 tanaman.  Hasil penelitian menunjukkan isolat Pseudomonas kelompok flourescens asal bambu, pakis dan cabai mampu menginduksi ketahanan tanaman tomat terhadap infeksi virus keriting kuning tomat dan hanya isolat Pseudomonas kelompok flourescens asal pakis yang mampu memacu pertumbuhan tanaman tomat.
“Trapdoor” Medial Scapula Osteotomy for Resection of a Benign Subscapular Neoplasm
Authors: Boubekri Amir M. , Lawler Patrick , Chen Andrew , Li Daphne , Prabhu Vikram C. , Garbis Nickolas G.
Published: February 2025

Case:

Neurofibromatosis type 2 (NF2) is an autosomal dominant condition characterized by the development of neoplasms, which infrequently arise in the subscapular fossa. Surgical removal of large subscapular tumors carries the risk of shoulder dysfunction due to muscle or nerve injury. We describe the case of a patient with NF2 who presented with a hybrid subscapular neurofibroma and schwannoma tumor that was completely resected through a muscle-sparing medial scapular osteotomy approach.

Conclusion:

We describe a unique muscle-sparing scapula splitting surgical approach to the subscapular region that provides excellent exposure for tumor removal and clinical outcomes with minimal postoperative scapular dyskinesis.

Level of Evidence:

IV (case report).
Non-Invasive Blood Pressure Monitoring with In-ear Infrasonic Hemodynography for Preventative Cardiovascular Care
Authors: Ciesielski Robert , Wong Christine S. , Panchal Jal , Grela Jacek , Dimalanta Christina , Walton Alison , Engstrom Hayley , Ring Marty , Abraham Jacob , Stinis Curtiss , Romero Steven , Barnacka Anna
Published: February 2025

Infrasonic Hemodynography (IH) is a novel, non-invasive technology that captures low-frequency cardiovascular vibrations transmitted to the ear canal and detected by in-ear microphones, offering a new approach to continuous blood pressure monitoring. In this study, we demonstrate a strong correlation between IH waveforms and gold-standard invasive aortic blood pressure measurements obtained via cardiac catheterization (CC), as illustrated in Wiggers diagrams with an average cross-correlation of 0.95. Temporal analysis confirmed the aortic origin of IH signals, with minimal differences in aortic valve opening (AVO) timings between IH and CC data (1.6 ± 12.1 ms), effectively rejecting the hypothesis of a peripheral arterial origin. Motivated by the high fidelity of the IH waveforms and the breadth of extractable cardiac features, we tested an approach to predict systolic (SBP) and diastolic (DBP) blood pressure based on waveform morphology, independent of amplitude. The standard deviations of the differences between predicted and reference BP values averaged across 12 subjects were 4.1 mmHg (SBP) and 2.4 mmHg (DBP) for CC data, and 5.8 mmHg (SBP) and 3.7 mmHg (DBP) for IH data. These results demonstrate that BP information is encoded in waveform shape dynamics, highlighting the potential of IH technology for non-invasive blood pressure monitoring. With larger and more diverse datasets, this approach could support the development of robust, generalizable BP prediction models for widespread clinical and consumer applications. Combined with advances in artificial intelligence and the widespread use of earbuds, IH technology has the potential to transform predictive and proactive healthcare. By capturing precise cardiovascular signals non-invasively, IH could enable earlier intervention and more personalized treatment, paving the way for significant improvements in the management of hypertension and overall cardiovascular care.
Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer’s disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions
Authors: Eysert Fanny , Legros Véronique , Gay Anne-Sophie , Debayle Delphine , Lacas-Gervais Sandra , Chevreux Guillaume , Bottlaender Michel , Dorothée Guillaume , Checler Frédéric , Potier Marie-Claude , Sarazin Marie , Lagarde Julien , Chami Mounia
Published: February 2025

In addition to small extracellular vesicles known as exosomes, cells release large extracellular vesicles containing mitochondria (EVMs). The molecular and functional characteristics of EVMs, as well as the impact of EVMs on the spreading of mitochondrial dysfunction between cells, remain unknown in the context of Alzheimer’s Disease (AD). Here, we provide an ultrastructural, biochemical, and functional characterization of EVMs isolated from neuroblastoma cells expressing the amyloid precursor protein with the familial Swedish mutations (APPswe). We identify differential proteomic and lipidomic signatures in APPswe-derived EVMs compared to control EVMs and revealed a specific proteomic profile in EVMs derived from fibroblasts of AD patients at the prodromal stage of the disease. Our findings show that the pathogenic accumulation of APP-C terminal fragments (APP-CTFs) potentiates the secretion of EVMs through plasma membrane budding. We demonstrate that APP-CTFs loaded EVMs are active carriers of dysfunctional mitochondria mediating the transfer of mitochondrial pathology between cells.
Migration Intention and the Related Factors among Nursing Students in Iran: A Cross-Sectional Study
Authors: Hasankhani Hanieh , Ghanbari Atefeh , Maroufizadeh Saman , Javadi-Pashaki Nazila
Published: February 2025

Background
Nurses’ migration as key personnel in healthcare organizations can negatively affect the nursing profession and the healthcare system. The intention and desire to migrate among nursing students, as the future nursing workforce, can pose additional challenges to the healthcare system.
Methods
In a descriptive cross-sectional study, 248 nursing students of the nursing and midwifery faculties of Guilan University of Medical Sciences were selected by multi-stage and convenience sampling method. The data was collected through a researcher-made questionnaire about the desire to migrate and the factors related to it.
Results
The results overall, revealed that the mean age of the students was 22.81 ± 3.55 years, the majority of students were female (%54.0), single (%92.3), engaged in bachelor’s degree (%88.3), interested in nursing (%70.6) and were in favor of emigrating from the country (%61.7). The average score of willingness to migrate was 66.3 ± 20.3. According to the regression results, experience living abroad (b = 13.12, P = 0.017), choosing nursing as a channel for immigration (b = 8.78, P = 0.017), medium foreign language proficiency (b = 6.36, P = 0.007), origin attraction (b = 0.39, P < 0.001) and destination attraction (b = 0.54, P < 0.001) exhibited a statistically correlation relationship with desire to migration (p < 0.05).
Conclusion
The desire of nursing students to migrate in this study was above average. Therefore, policymakers need to design and implement strategies such as improving the economic conditions of nurses and reforming educational policies to enhance the attractiveness of the nursing profession within the country and retain nursing graduates.
Reconstructing Territory of Chaundkot Fort in Garhwal Himalaya:An Ethno-Archaeological Model
Authors: Rawat Nagendra , Nautiyal Vinod
Published: February 2025

Following the decline of Katyuri rule in 10th century CE, Garhwal Himalaya witnessed a fragmented political system governed by 32 major principalities. Each principalities had their one major fort and numerus small fortalices which formed a unique political landscape in this mountainous region. But despite scholarly interest and existing literature, scholars largely catalogue these forts without delving into their political significance and territorial reach. Therefore, present research problem was taken up to addresses this gap by focusing on the territory of the Chaundkot fort (one of the major forts of region) employing ethnography, historical maps, and usage of Geographical Information System application to construct the most plausible territorial model of Chaundkot fort in Garhwal Himalaya.
Impact of Volumetric Changes in the Upper Airways after Orthognathic Surgery: Study Pilot
Authors: Soares Cauê Fontan , Aguiar Priscila Lins , Lago Carlos Augusto Pereira do , Silva Neto Joaquim Celestino da
Published: February 2025

OBJECTIVE: The aim of the present study was to assess volumetric changes in the upper airways of patients submitted to orthognathic surgery and the impact on quality of life. METHODS: The study evaluated clinical and psychosocial aspects of patients undergoing orthognathic surgery at Hospital Getúlio Vargas in the city of Recife, Brazil, in 2019 and 2020. A prospective longitudinal study pilot was carried out. Quality of life, self-esteem, obstructive sleep apnea syndrome symptoms and upper airway volume changes were assessed preoperatively and over one year postoperatively. RESULTS: Eight patients (three men and five women) agreed to participate in the study and answered the questionnaires in the preoperative and postoperative periods. Three were between 18 and 24 years of age and five were between 25 and 44 years of age. Half of the patients had the long face pattern (50%) and most had occlusal pattern III (87.5%). Although the average volume and minimum cross-sectional area had diminished in the overall sample, a reduction occurred in signs and symptoms of obstructive sleep apnea syndrome. Surgery also had a strong impact on quality of life assessed using the OHIP-14 and orthognathic quality of life questionnaire. CONCLUSION: Orthognathic surgery exerts a positive impact on quality of life and self-esteem. However, airway size is not a determinant of this improvement.
Laceração Transfixante Facial em Região de Mento: Relato de Caso
Authors: Scariot Alexandre Thalissa , Ramires Volpato Bruna , Pelissaro Gustavo Silva , Figueiredo Francielly Thomas , Silva Julio Cesar Leite , Gaetti Jardim Ellen Cristina
Published: February 2025

As lacerações faciais correspondem aos danos cortantes ou perfurantes da estrutura epitelial envolvendo grandes extensões e profundidades, sendo um dos problemas mais comuns encontrados em unidades de emergência. O tratamento varia de acordo com a extensão, profundidade, grau de contaminação, etiologia e tempo decorrido do trauma, sendo este um fator fundamental para definir o resultado. O objetivo desse trabalho é direcionar a melhor conduta ao cirurgião bucomaxilofacial, através de um relato de caso de um paciente com laceração transfixante em face, levando em consideração a relevância dos aspectos estéticos, funcionais e psicológicos envolvidos. O relato de caso a ser abordado é de um paciente do sexo masculino, 59 anos de idade, que foi admitido no Hospital Universitário Maria Aparecida Pedrossian, após 24 horas do episódio de acidente por coice de animal. O acometimento ocorreu na região anterior de mandíbula, apresentando laceração transfixante em região mentual com áreas necróticas de aproximadamente 3 cm de comprimento, além de outra laceração em região submentual já suturada em Unidade Básica de Saúde. Apresentou comunicação da laceração à oroscopia e não apresentou degraus à palpação, tampouco mobilidade óssea, quadro confirmado pela tomografia computadorizada. O tratamento foi realizado sob anestesia local, consistindo no desbridamento e sutura da laceração transfixante. Além disso, foi solicitada uma dose de imunoglobulina antitetânica e foram prescritas terapia antibiótica, anti-inflamatória e analgésica, juntamente às orientações pós-operatórias e retorno ambulatorial agendado para o 7º dia pós-operatório. No retorno ambulatorial, observou-se aspecto satisfatório da abordagem cirúrgica. Deste modo, é certo que o tratamento cirúrgico da laceração transfixante deve ser preconizado, uma vez que está ligado a reparação tecidual fornecendo um resultado estético-funcional mais previsível.
Full-scale characterization of the effects of a bioretention system on water quality and quantity following the replacement of a mixed stormwater and combined sewer system
Authors: Le Cauchois Pia , Doucet Samuel , Bouattour Ons , McQuaid Natasha , Beral Henry , Kõiv-Vainik Margit , Bichai Françoise , McCarthy David , St-Laurent Julien , Dagenais Danielle , Bennekrela Nesrine , Guerra Juan , Hachad Mounia , Kammoun Raja , Dorner Sarah
Published: February 2025

Urbanization is leading to more frequent flooding as cities have more impervious surfaces and runoff exceeds the capacity of combined sewer systems. In heavy rainfall, contaminated excess water is discharged into the natural environment, damaging ecosystems and threatening drinking water sources. To address these challenges aggravated by climate change, urban blue-green water management systems, such as bioretention cells, are increasingly being adopted. Bioretention cells use substrate and plants adapted to the climate to manage rainwater. They form shallow depressions, allowing infiltration, storage, and gradual evacuation of runoff. In 2018, the City of Trois-Rivières (Québec, Canada) installed 54 bioretention cells along a residential street, several of which were equipped with access points to monitor performance. Groundwater quality was monitored through the installation of piezometers to detect potential contamination. This large-scale project aimed to improve stormwater quality and reduce sewer flows. The studied bioretention cells reduced the flow and generally improved water quality entering the sewer system, as well as the quality of stormwater, with some exceptions. Higher outflow concentrations were observed for contaminants such as manganese and nitrate. The results of this initiative provide useful recommendations for similar projects for urban climate change adaptation.
Odontometric parameters of adults of the early Middle Ages living in Penza region
Authors:   Penza State University, V. Kalmin Oleg , G. Kavtaeva Galina ,   Penza State University, A. Zyulkina Larisa ,   Penza State University, V. Sgibneva Natal'ya ,   National Research State University of Nizhny Novgorod named after N.I. Lobachevsky
Published: February 2025

Background. The study examines the odontometric parameters of adults of the early Middle Ages who lived in Penza region. The relevance of the topic of odontological variability is related to the need to understand the historical context of the lives of people who lived in the early Middle Ages, as well as the adaptive mechanisms of the dental system to changing environmental conditions and socio-cultural environment. The purpose of the work is to collect data on the relative and absolute odontometric parameters of the adult population of the early Middle Ages who lived in Penza region. Materials and methods. The study materials were teeth of 40 adults, among them incisors – 68, canines – 47, premolars – 95, molars – 129, stored in the anthropological laboratory of the sub-department of Human Anatomy of the Medical Institute of Penza State University. The odontometric study was carried out according to the method of A.A. Zubov and included measuring the height, width, length of crowns and root, as well as calculating the massiveness and modulus of crowns. Results and conclusions. The result of the study was to obtain and systematize information on the odontological characteristics of anthropological material dated from the 2nd – 4th centuries. Within the group the siza ratios of frontal and lateral teeth were established, the parameters of scientific research aimed at studying the phylogenetic variability of elements of the human dental apparatus, determining the level and direction of population migration, and identifying phylogenetic kinship with remote populations were determined.
The hemostasis-regulating function and metabolism of liver in diabetes mellitus (literature review)
Authors:   Ogarev Mordovia State University, S. Yakushkina Anastasiya , V. Sergachev Andrey ,   Ogarev Mordovia State University, G. Sardaeva Darya ,   Ogarev Mordovia State University, R. Kazakov Ruslan ,   Ogarev Mordovia State University, I. Vlasova Tatyana ,   Ogarev Mordovia State University
Published: February 2025

Studying the role of the liver in coagulopathy in diabetes mellitus is of great interest from the point of view of the complications frequency associated with this condition. The article provides a review of modern literary sources covering the mechanisms of changes in liver function in diabetes mellitus in terms of the inclusion of the plasma component of the hemostasis system. The factors influencing the quantity and quality of production of plasma coagulation factors under conditions of hyperglycemia and insulin resistance are considered. In the course of hypercoagulemia, patient innovation was demonstrated, such as diabetes mellitus, the level of hyperglycemia and its controllability. The following are considered as the main indicators of increasing the production of plasma hemostasis factors: the synthesis of pro-inflammatory cytokines by adipocytes, endothelium and cells of the immune system; hormonal drugs on the liver and features of hepatic insulin resistance; endothelial dysfunction. A decrease in the quantity and quality of plasma hemostasis factors associated with the progression of NAFLD to liver fibrosis and cirrhosis; predisposition of patients with diabetes mellitus to the development of diseases of the biliary system and changes in the composition of intestinal microbes, which leads to disruption of vitamin K metabolism.
A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders
Authors: Moin Hira , Ashraf Rizwan , Butt Batool , Mustafa Imtiaz , Shafiq Mamoona , Shah Sayed Ali Raza
Published: February 2025

Autophagy is a self-eating cellular process in which the cell breaks down worn-out organelles,
damaged/defective proteins, and toxins. Impaired autophagy is a significant factor in the
development of various metabolic disorders, along with oxidative stress, inflammation, mitochondrial
and endoplasmic reticulum dysfunction. These disorders pose a significant health and economic
burden on the global human population, owing to their steadily rising prevalence. Therefore,
modulating the expression of proteins involved in the autophagy-related pathways can be a
promising avenue for curbing the development and progression of these disorders. Humanin (HN)
is a 24-amino acid mitochondrial-derived peptide. It possesses anti-oxidant, anti-inflammatory,
and pro-apoptotic properties. The analogs of HN can be generated by replacing specific amino
acids in the polypeptide chain, thereby functionally modifying the peptide. Among these, humanin-
glycine (HNG) is the most widely studied analog in both in vivo and in vitro disease models. It
is far more potent than HN, with a potency that is 1000 times greater. To the best of our knowledge,
this review is the first to discuss and examine the available evidence regarding the potential
involvement of HN or its analogs in regulating autophagy pathways. The review primarily highlights
that HN is an autophagy inducer, which can promote cell survival in the presence of
metabolic and oxidative stress, particularly the HNG analog. Future research is imperative to comprehensively
evaluate the effects of HN and its analogs on autophagy. Further investigations are
needed to correlate its levels with various autophagic markers in different metabolic diseases, offering
the potential for groundbreaking discoveries in understanding disease mechanisms and developing
novel therapeutic strategies.
Recent Advances in Cationic Nanoemulsions for Drug Delivery: Preparation, Properties, and Applications
Authors: He Huanfan , Li Jiayu , Meng Hong , He Yifan , Pei Xiaojing , Zhang Ze
Published: February 2025

Nanoemulsions have gained popularity as drug delivery vehicles owing to the enhanced solubility
of insoluble drugs, the augmented stability of photo- and thermosensitive substances, and the facilitation of
transdermal permeation of efficacy substances. As the cell surfaces of the skin, cornea, gastrointestinal mucosa,
and other cells in living organisms carry negative charges, cationic nanoemulsions (CNE) mainly promote
drug absorption through electrostatic effects. In this review, a brief characterization of CNEs is provided, and
the types of cationic agents and their roles in nanoemulsions, including cationic surfactants, cationic lipids,
cationic polymers, cationized polysaccharides, and phytosphingosine (PS), are discussed. In addition, the current
application circumstances of CNEs in ocular drug delivery, mucosal drug delivery, and transdermal drug
delivery systems are elaborated on, and the crucial matters that require attention during the research process
are briefly discussed. Eventually, the extensive application prospects of CNEs are envisioned.
The Efficacy and Safety of Direct Oral Anticoagulants Compared to Warfarin in Morbidly Obese Patients on Anticoagulation: A Systematic Review and Meta-Analysis
Authors: Sagris Marios , Ktenopoulos Nikolaos , Pamporis Konstantinos , Gerogianni Maria , Karakasis Paschalis , Theofilis Panagiotis , Patsourakos Nikolaos , Toutouzas Konstantinos , Tsioufis Konstantinos , Tousoulis Dimitris
Published: February 2025

Introduction:

Current guidelines and consensus statements advise caution in using direct
oral anticoagulants (DOACs) for morbidly obese patients with body mass index (BMI) >40 kg/m2,
indicating warfarin as the most studied treatment.

Methods:

We systematically searched databases from their inception to January 4, 2024, to identify
studies that evaluated the effectiveness and safety of DOACs compared to warfarin in patients with
BMI >40 kg/m2 and atrial fibrillation (AF) or venous thromboembolism (VTE). The outcomes of allcause
mortality, major and minor bleeding, stroke/systematic embolism (SE), VTE, and their composite
endpoint were analyzed using a random-effects model.

Results:

This meta-analysis included 24 studies and 119,960 morbidly obese patients with AF or
VTE on oral anticoagulation therapy: 51,363 on DOACs (43%) vs. (57%) 68,597 on warfarin. DOAC
use was significantly associated with lower all-cause mortality and major bleeding risk compared to
warfarin. Although the risk of composite endpoint, stroke/SE, and VTE was lower in the DOAC
group, no statistically significant difference was observed, indicating no superiority of warfarin compared
to DOAC use. The risk of minor bleeding events, hemorrhagic stroke, and ischemic stroke was
lower in the DOAC compared to the warfarin group. The same trend favoring DOACs over warfarin
in all assessed endpoints was observed in the subgroup analysis based on anticoagulation indication
(AF or VTE).

Conclusion:

Our findings have documented a potentially more effective and safer profile of DOACs
compared to warfarin in morbidly obese patients regardless of the indication for anticoagulation.