bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Online Debate in Training Future Specialists' (Philologists) and Enhancing Their Professional Competencies
Authors: Sydorenko Olha , Voshkolup Hanna , Kupina Іryna , Kovalenko Borys , Kovalenko Nataliia
Published: December 2023

The pedagogical science has always been interested in the problem of identifying effective mechanisms for building future specialists’ professional competencies. The development of telecommunications made educational institutions face the challenge of finding effective forms of interaction between students. Student online debates are one of the forms that contribute to the professional competence development. Methods: surveys and questionnaires, remote collection and processing of information, reduced version of the Multifactor Personal Questionnaire B5-10; Academic Motivation Scale; Short Self-Control Scale; Diagnostics of the Dominant Perceptual Modality; Raven’s Progressive Matrices. Statistical analysis was carried out using the Kolmogorov-Smirnov test, Spearman’s Rank correlation coefficient, and the Mann–Whitney U test was used to assess the reliability of differences between contrasting groups. According to the research findings, students are convinced that participation in debates can contribute to the professional competence development. Students’ diligence was indicated as the main component of motivation for building professional competencies. It was established that most students rate their speeches during the debates higher than they actually are. It was found that students’ participation in online debates contributes to the improvement of professional competencies. Further research should be aimed at studying the role of debates in building professional competencies among students of narrow majors. It is also necessary to develop a detailed methodology of introducing the student debate model into the educational process.
Acceso de los indígenas a la justicia: aportes de la corte interamericana y del consejo nacional de justicia brasileño
Authors: D'ávila Lopes Ana Maria
Published: December 2023

Durante siglos, la diversidad no apenas no fue valorizada como una característica inherente de la humanidad, sino que fueron construidas teorías y elaboradas normas para excluir todo aquel que no se encuadraba en el modelo de ser humano considerado “ideal” (hombre blanco adulto, de cultura europea, heterosexual, saludable y propietario). Es con base a esa idealización que los indígenas fueron discriminados y tuvieron muchos de sus derechos limitados. Los últimos años, esa situación viene siendo revertida, permitiendo encontrar diversos documentos jurídicos y jurisprudencia direccionados a proteger la diversidad humana. En ese contexto, el presente artículo busca destacar las contribuciones de la Corte Interamericana de Derechos Humanos (CorteIDH) y del Consejo Nacional de Justicia (CNJ) brasileño para garantizar la protección efectiva del derecho de los indígenas al acceso de la justicia, dada su esencialidad para proteger otros derechos. De ese modo, mediante una investigación doctrinaria, legislativa y jurisprudencial, se constató que los Estados tienen la obligación de garantizar el acceso a la justicia a todos, sin distinción, pues constituye un pilar del Estado de Derecho. Fueron también identificadas las contribuciones de la CorteIDH y del CNJ para garantizar el efectivo ejercicio del acceso a la justicia de los indígenas, mostrando importantes avances para la reversión de la situación de desigualdad en la cual aún se encuentran.
A Convenção nº 169 da OIT e o direito à consulta prévia, livre e informada: relação com o princípio da dignidade da pessoa humana
Authors: Martins Domingos João Victor , De Moraes Braga Junior Sergio Alexandre , Alves Fernandes Brenda Camilli
Published: December 2023

Os indígenas são povos com uma riqueza cultural e histórica muito grande para a humanidade, especialmente, no Brasil. No entanto, esses sofrem com diversas ameaças que buscam torná-los invisíveis. O objetivo do presente trabalho é analisar o direito à consulta prévia, livre e informada, previsto na Convenção nº 169 da OIT, diante do conteúdo do princípio da dignidade da pessoa humana no direito brasileiro. Quanto à metodologia, realizou-se uma pesquisa na modalidade qualitativa e exploratória, partindo de uma abordagem dedutiva. Acerca dos procedimentos técnicos, foram utilizadas a pesquisa bibliográfica e documental. O direito à consulta prévia, livre e informada está relacionado com o princípio da dignidade da pessoa humana, afinal, atua garantindo a autonomia e autodeterminação dos povos indígenas, isto é, permite que esses interessados possam decidir os seus destinos e contribuir com a tomada de decisão; o reconhecimento, pois proporciona um diálogo intercultural com as populações tradicionais; a dimensão ecológica do mínimo existencial, permitindo uma prevenção de danos e impactos negativos aos indígenas diante de atividades econômicas. A ADPF nº 709, na sua fundamentação, ressalta justamente os elementos da autonomia e do reconhecimento ao abordar o citado direito. Estudar tais elementos é essencial para o aperfeiçoamento de instrumentos que objetivem a garantia dos direitos dos indígenas, sendo sugerido realizar outras pesquisas futuras sobre a aplicação do direito à consulta prévia, livre e informada por parte de cortes brasileiras e internacionais.
COMO VAYA YO Y LO ENCUENTRE. FEMINISMO ANDALUZ Y OTRAS PRENDAS QUE TÚ NO VEÍAS. MAR GALLEGO, MADRID, LIBROS.COM, 2020, 274 PP. (ISBN: 978-84-17993-85-6)

Authors: Blanco Martínez Miguel Ángel
Published: December 2023

Review of COMO VAYA YO Y LO ENCUENTRE. FEMINISMO ANDALUZ Y OTRAS PRENDAS QUE TÚ NO VEÍAS. MAR GALLEGO, MADRID, LIBROS.COM, 2020, 274 PP. (ISBN: 978-84-17993-85-6)
DE POETISAS Y ERUDITAS: EN TORNO A UN TEXTO RECIENTEMENTE RECUPERADO
DE CAROLINA CORONADO
Authors: Ferrari Marta Beatriz
Published: December 2023

En el presente trabajo nos proponemos realizar un acercamiento al artículo “La erudita” (1845), de Carolina Coronado. Si bien se sabía de su existencia por el epistolario entre Coronado y Hartzenbusch, y también por la Historia y Bibliografía de la Prensa de Badajoz (1901), de Román Gómez Villafranca, donde aparece incluido en el periódico El Pensamiento, dicha publicación se consideró extraviada hasta finales del año 2022, cuando la bibliófila Carmen Fernández-Daza logra ubicarla en una Universidad de EE.UU. “La erudita”, como veremos, resulta un texto de sumo interés porque revela la centralidad que tuvo el tema de la mujer escritora (poetisa, literata, erudita) en el siglo XIX español.
DEL INTERCAMBIO DE MUJERES A LA ALIANZA Y LA AMISTAD: CONFIGURACIONES DE GÉNERO Y NACIÓN Y SUS POSIBLES FUGAS EN ENTRE VISILLOS (1957) Y NUBOSIDAD VARIABLE (1992) DE CARMEN MARTÍN GAITE

Authors: Lamarca Sofía Beatriz
Published: December 2023

A partir de las novelas Entre visillos (1957) y Nubosidad variable (1992) de la escritora española Carmen Martín Gaite, este artículo se propone analizar las representaciones de la construcción identitaria - identidad de género e identidad nacional- y sus posibles desvíos o espacios de fuga (Deleuze y Guattari, 1988). De este modo, se plantea el trabajo con una primera novela de juventud y una última de madurez. Se espera dar cuenta del modo en que la narración construye una identidad normativa en función de un determinado modelo nacional y sus necesidades, a la vez que la aparición de la escritura y el uso de la primera persona permiten cuestionar y desafiar esa identidad opresiva traducida en el sintagma de mujer española. Como marco teórico central, este escrito usará los conceptos de intercambio de mujeres (Gayle Rubin, 1975) y la configuración de la afectividad entre mujeres, ambos vinculados con la heterosexualidad obligatoria (Monique Wittig, 1992; Adrianne Rich, 1980).
EL PAPEL DE LAS MUJERES EN LA EDUCACIÓN INFANTIL EN BRASIL Y EN PORTUGAL: ESTRATEGIAS LÚDICAS Y PRÁCTICAS PEDAGÓGICAS

Authors: Coelho Barbosa Keila
Published: December 2023

En este artículo, a partir de una investigación realizada en trece escuelas infantiles de las ciudades de Lisboa, en Portugal y de Imperatriz, en Brasil, se analiza el papel desempeñado por las maestras de Educación Infantil en la aplicación de estrategias pedagógicas lúdicas. Para ello se parte de la hipótesis de la influencia de factores personales, ambientales y culturales en la determinación del grado y modo de aplicación de dichas estrategias. La información obtenida, a partir de entrevistas y cuestionarios, permitió verificar que dichos factores actuaron como elementos condicionantes de la concepción y práctica de las estrategias lúdicas por parte de estas educadoras
Design and Performance of an Electrowetting Ionic Liquid Electrospray Thruster Prototype
Authors: Sun Wei , Guo Yuntao , Wu Zhiwen , Du Zening , Wang Ningfei , Sun Zhenning
Published: December 2023

Porous ionic liquid electrospray thrusters are capable of meeting the propulsion requirements of micro- and nanosatellites. The liquid propellant of such a thruster is usually prefilled in the porous reservoir and emitter, then passively and uncontrollably supplied to the emitter tip, which may cause excessive propellant to submerge the emitter, thereby resulting in a short circuit of the thruster. To solve the aforementioned problems, an electrowetting ionic liquid electrospray thruster prototype is developed in this study. Electrowetting is an active control technology that can supply propellant on demand from the propellant tank to the emitter. The feasibility of electrowetting the emitter and the performance of the prototype are tested in a vacuum chamber. The results show that the porous reservoir is completely wetted by the propellant within 410 s after the electrowetting process is initiated. The prototype can work stably in the voltage range of [Formula: see text] to [Formula: see text], with a transmission efficiency of greater than 95%. The maximum specific impulse and thrust of this prototype are 5025 s and [Formula: see text], respectively, which are similar to the performance characteristics of passively fed prototypes. This study is of great significance for improving the controllability and robustness of ionic liquid electrospray thrusters.
Stable Vortex Particle Method Formulation for Meshless Large-Eddy Simulation
Authors: Alvarez Eduardo J. , Ning Andrew
Published: December 2023

A novel formulation of the vortex particle method (VPM) is developed for large-eddy simulation (LES) in a meshless scheme that is numerically stable. A new set of VPM governing equations are derived from the LES-filtered Navier–Stokes equations. The new equations reinforce the conservation of angular momentum by resizing vortex elements subject to vortex stretching. In addition to the VPM reformulation, a new anisotropic dynamic model of subfilter-scale (SFS) vortex stretching is developed. This SFS model is well suited for turbulent flows with coherent vortical structures, where the predominant cascade mechanism is vortex stretching. The mean and fluctuating components of turbulent flow and Reynolds stresses are validated through the simulation of a turbulent round jet. The computational efficiency of the scheme is showcased in the simulation of an aircraft rotor in hover, showing our meshless LES to be 100 times faster than a mesh-based LES with similar fidelity. The implementation of our meshless LES scheme is released as open-source software, called FLOWVPM.
Sexuality in Abubakar Adam Ibrahim’s Season of Crimson Blossoms
Authors: Adeleke Israel Oluwaseun
Published: December 2023

Sexuality is a topical preoccupation in literature whether queer, perverse or conventional. In some societies, sexuality is a pious topic that hardly receives literary and critical attention. Abubakar Adam Ibrahim’s Season of Crimson Blossoms narrativises sexuality in a strict Islamic society and focalises the sexual interplay between Binta and Reza. This article examines the sexuality in the novel through Sigmund Freud’s psychoanalytic theory. Freud proposes that suppressed desires, an unresolved Oedipus complex, and past traumas impact people’s current behaviour. I contend that repressed wishes and the traumas of lingering parent-child conflicts stimulate the eros between Binta and Reza in the narrative and that Ibrahim’s subtle patriarchal ideology underlies the outcome of their sexuality.  The memory and trauma of parent-child schisms experienced by Binta and Reza transmute to fetishism that leads to psychic transference, which collapses desired filial personalities into symbolic sexual figures. I conceive this conflation as symbolically incestuous and interrogate the novel’s conscious and unconscious layers by appropriating Freud’s topographical taxonomy of the psyche as a metaphor. The unconscious symptomises the patriarchal ideology that undercuts the conscious female sexual desires depicted, and this latently sustains established cultural precepts that repress emancipatory sexuality.
Prohibited Relationships With Women within the Extended Family: Leviticus 18:7–18 Compared With Surah Al-Nisa’ 4:22–23
Authors: Dockrat Ashraf
Published: December 2023

Various unlawful sexual relationships are the topic of Leviticus 18, concentrating (vv. 7–18) on women within the extended family who may not be approached. A comparable but condensed list of taboo relationships is stated in the Qur’anic Surah al-Nisa’ (The Women) 4:22–23. The first objective of the article is to give an account of the way the respective directives are expressed. Prohibitions in Lev 18:7–18 are, for example, introduced by the formula, “The nakedness of … do not uncover,” usually followed by a reason, e.g., “the nakedness of … she is.” The Qur’anic portion begins with the restriction, “And do not marry” (Q al-Nisa’ 4:22), or “Forbidden to you [are]” (Q al-Nisa’ 4:23). Secondly, individual taboos which are shared, or only found in either of the two sources, are scrutinised. Thirdly, the arrangement of the items in the two lists is investigated. Fourthly, the literary contexts of the biblical and Qur’anic portions are juxtaposed.
Perspectives of Library and Information Science Undergraduate Students on Library User Education and Use of the Library at the University of Port Harcourt, Nigeria
Authors: Horsfall Millie Nne , Wokoma Prince Batubo
Published: December 2023

In the study, we examined perspectives of Library and Information Science undergraduate students on library user education and the use of the Donald E.U. Ekong Library at the University of Port Harcourt in Rivers State, Nigeria. Five specific objectives with corresponding research questions guided the study and one hypothesis was formulated. In the study, we adopted the descriptive survey research design. The population of the study consisted of 194 students in the Department of Library and Information Science. A sample size of 131 respondents was selected using a simple random sampling technique. The instrument for data collection was a self-developed structured questionnaire titled “Library Information Science Undergraduate Students’ Library User Education and Use of Library” and was distributed among the students. The 131 (100%) questionnaires were returned in good shape and analysed using frequency, percentages and mean. The hypothesis was tested using Pearson’s product moment correlation at a 0.05 level of significance. The findings of the study revealed that library orientation, the lecture method and the library tour were the methods used in teaching user education at the Donald E.U. Ekong library, while the online course was poor. We concluded that user education has a positive influence on these undergraduate students’ library use. Our recommendations included that a conducive environment for, creating awareness on and advocacy of user education and the use of the library be adopted as ways to improve the library user education at the Donald E.U. Ekong Library.
The Records Management (RM) Capabilities of Lecturers at Midlands State University (MSU), Zimbabwe
Authors: Chitima Simbarashe Shadreck , Dewah Peterson
Published: December 2023

Records bear evidence of business transactions and decisions undertaken by an organisation. Good records management enables the smooth flow, efficient and effective conduct of university business. University lecturers create different types of records in the course of discharging their responsibilities. These include research and publications, student teaching, continuous assessment, and examination. However, very little is known about the extent to which lecturers are able to properly manage the records they create. There have been three recorded cases of lecturers at Midlands State University (MSU) who lost examination and continuous assessment records, and this led to their dismissal. This study examined the capabilities of university lecturers in managing the records they create. The objectives of the study were to ascertain the records management background of lecturers and to examine their capability to perform records management. This study was grounded on the interpretive paradigm and employed qualitative research approaches where convenience sampling was used. The sample of the study involved 23 lecturers and one staff member from the Central Records section at MSU. The study found that participating lecturers lacked records management knowledge, and all of them did not follow any records management system for paper-based records management. Lecturers managed coursework and examination records through the Changamire Marks Management System. Some electronic records were kept in lecturers’ e-mails and personal laptops. The study established that records were susceptible to loss due to lecturers’ lack of knowledge, negative attitudes, conflicts between non-teaching and teaching staff, and lack of suitable records management infrastructure. The study concluded that most lecturers who participated in the study were dismal performers of records management; hence, records are more susceptible to loss. This study provides a step by step systems approach that universities, such as MSU, can employ to effectively manage records created by academic staff.
Selective Gamma-Ray Ionisation of Vanadium Oxides: Towards the Formation of VO2
Authors: Ndiaye M. , Sakh O. , Seck A. , Ngom B. D. , Maaza M. , Chaker M.
Published: December 2023

In this study, we report on the valence control of vanadium oxidation states towards stabilising VO2 thin films. X-ray diffraction measurements indicate that up to 300 kGy of gamma-ray radiation the VO2 phase remains monoclinic, with the crystallite size only varying slightly with the dose. X-ray photoemission spectroscopy indicates the presence of three oxide phases (VO2, V2O3 and V2O5) on the samples. A decrease in the oxidation states of V3+ and V5+ and an increase in the valence state V4+ are observed for irradiations up to 300 kGy, which favours the vanadium dioxide VO2 formation.
Praktik Pemberian Makan pada Balita Stunting di Desa Kawitan, Kecamatan Salopa, Kabupaten Tasikmalaya
Authors: Karimah Ima , Nuraeni Irma , Hadiningsih Naning
Published: December 2023

Stunting masih menjadi permasalahan nasional di Indonesia. Prevalensi stunting di Indonesia saat ini 21,6%. Target prevalensi stunting pada tahun 2024 yaitu 14%. Oleh karena itu, perlu penurunan 3,8% per tahun untuk mencapai target tersebut. Salah satu faktor penyebab kejadian stunting yaitu asupan makanan yang tidak optimal pada balita. Asupan energi, protein, kalsium, zat besi, dan seng dapat meningkatkan risiko terjadinya stunting. Terdapat beberapa wilayah di Jawa Barat yang mengalami peningkatan prevalensi stunting, salah satunya Kabupaten Tasikmalaya. Desa Kawitan merupakan salah satu desa yang memiliki prevalensi stunting tinggi. Prevalensi stunting di Desa Kawitan 42,73%. Oleh karena itu peneliti tertarik untuk mengkaji bagaimana praktik pemberian MP-ASI pada balita stunting di Desa Kawitan, Kecamatan Salopa, Kabupaten Tasikmalaya. Tujuan penelitian adalah untuk mengetahui bagaimana praktik pemberian makan pada balita stunting. Metode yang digunakan yaitu kualitatif dengan cara focus group discussion (FGD). Populasi dalam penelitian ini adalah ibu balita yang memiliki anak stunting di Desa Kawitan, Kecamatan Salopa, Kabupaten Tasikmalaya. Jumlah informan adalah 10 ibu balita yang memiliki anak stunting. Hasil penelitian menunjukkan bahwa frekuensi makan pada balita stunting dalam penelitian ini beragam mulai dari 1-4 kali dalam sehari. Makanan yang diberikan dalam satu kali makan belum beragam. Porsi yang diberikan juga belum sesuai anjuran setiap harinya. Hampir semua anak balita lebih sering mengonsumsi makanan selingan yang tidak padat gizi daripada makan utama.
Dampak Intensitas Penggunaan Instagram terhadap Body Dissatisfaction, Perilaku Makan, dan Status Gizi pada Remaja
Authors: Wassalwa Ulis Salsabila , Khomsan Ali
Published: December 2023

Media sosial yang menampilkan figur tubuh ideal menyebabkan remaja membandingkan bentuk tubuhnya dengan standar sosial. Hal tersebut mendorong remaja melakukan berbagai upaya seperti diet berlebih yang berdampak pada citra tubuh, perilaku makan, dan status gizi. Penelitian ini bertujuan untuk menganalisis dampak intensitas penggunaan instagram terhadap body dissatisfaction, perilaku makan, dan status gizi remaja di Kota Jakarta dan Kabupaten Bogor. Perbedaan demografi bertujuan untuk melihat adanya perbedaan dampak instagram terhadap kedua lokasi tersebut. Desain penelitian menggunakan cross sectional study yang terdiri dari 100 subjek yang dipilih secara purposive sampling. Data dikumpulkan melalui wawancara dan self-administered. Sebagian besar subjek masuk kedalam kategori light user pada penggunaan instagram (69%), memiliki persepsi body dissatisfaction (57%), tergolong dalam tipe perilaku makan external eating (68%), beresiko mengalami gangguan makan (12%), dan memiliki status gizi normal (69%). Tidak terdapat pengaruh signifikan antara intensitas penggunaan instagram terhadap body dissatisfaction, perilaku makan dan status gizi (p>0,05). Instagram tidak secara langsung mempengaruhi body dissatisfaction, perilaku makan, dan status gizi remaja, namun terdapat faktor-faktor lain yang berkontribusi lebih besar seperti interpersonal subjek, asupan makan, dan sosio demografi lainnya.
Implicações clínicas do uso de Inibidores de SGLT2 no manejo da insuficiência cardíaca
Authors: Benedito Renan de Almeida , Moraes Thiago Rocha Pereira de , Murari Mariana Carvalho , Amorim Larissa Pereira , Souza Sophia Lorenzato de , Simone Maria Rosa Ramos , Batista Guilherme Matheus , Viana Clara Freire , Hora Giovanna Carvalho Estefane da , Silveira Amanda Carolina Zicatti da
Published: December 2023

Objetivo: Avaliar as implicações clínicas do uso de inibidores de SGLT2 no manejo da insuficiência cardíaca. Métodos: Por meio da plataforma de base de dados PubMed, foi realizada uma Revisão Integrativa, com o intento de localizar fontes relevantes para tal. A pesquisa foi realizada sob o uso dos termos MeSH "Sodium-Glucose Transporter 2 Inhibitors", "Heart Failure", em associação com o uso do termo booleano “AND” para fazer a busca dos artigos, resultando em 985 artigos iniciais. Dentro desses números, devido aos critérios de inclusão e exclusão, apenas 21 foram selecionados para análise. Resultados: O uso dos fármacos inibidores SGLT2, dispõem de um alto nível de segurança e tolerabilidade em pacientes com IC e mostrou prevenir as deteriorações clínicas inerentes ao quadro clínico de um paciente com IC, bem como promover a melhora dos resultados cardiovasculares independente do estado de diabetes, reduzir a morte por todas as causas, reduzir a primeira internação por IC, bem como os desfechos renais adversos. Considerações finais:  os inibidores de SGLT2 são benéficos em pacientes com insuficiência cardíaca e fração de ejeção reduzida, mesmo na ausência de diabetes.  Por isso, são recomendados pelas diretrizes como uma terapia adicional aos tratamentos padrão para insuficiência cardíaca.
O impacto do uso de dispositivos de monitoramento contínuo de glicose no controle glicêmico e na qualidade de vida de pessoas vivendo com diabetes tipo 2
Authors: Santos Luany Gomes Ferreira dos , Corrêa Victória Goelzer Ferreira Lasch , Paredes Beatriz Dias , Paula Ana Carla Maia Rodrigues de , Santos Kristian Cavalcanti , Souza Sophia Lorenzato de , Fabiano Érica Domiciano , Ramos Leonardo Pizzolatti Miranda , Simioni Marina de Souza , Silveira Amanda Carolina Zicatti da
Published: December 2023

Objetivo: Analisar o impacto do uso de dispositivos de monitoramento contínuo de glicose no controle glicêmico e na qualidade de vida de pessoas vivendo com diabetes tipo 2. Métodos: Por meio da plataforma de base de dados PubMed, foi realizada uma Revisão Integrativa, com o intento de localizar fontes relevantes para tal. A pesquisa foi realizada sob o uso dos descritores “Blood Glucose Self-Monitoring", “Continuous Glucose Monitoring”, “Diabetes Mellitus, Type 2" e "Diabetes Mellitus, Type 1", em associação aos operadores booleanos “AND” e "OR" e "NOT”, para a busca dos artigos, resultando em 853 artigos iniciais. Dentro desses números, devido aos critérios de inclusão e exclusão, apenas 23 foram selecionados. Resultados: Os estudos apontam estreita ligação entre o monitoramento contínuo de glicose e a redução do risco e da frequência de episódios de hipoglicemia e hiperglicemia, além de redução e/ou manutenção da HbA1c e prevenção da deterioração glicêmica em pacientes com DM2. Considerações Finais: O uso do monitoramento contínuo de glicose em pacientes com DM2 auxilia na regulação glicêmica, minimiza a incidência de episódios hiperglicêmicos e hipoglicêmicos e otimiza o estilo de vida do paciente, contudo não aparenta reduzir o desconforto geral causado pelo diabetes.
Seismic effect of steel bracing systems in RC frame models
Authors: Kumar Madan , Kumar Vijay , Kumar Kunal , Kumar Ashish , Priyadarshee Akash
Published: December 2023

A bracing system is a common type of construction used in multi-storyed buildings for strengthening the structure. This type of technique may be used for retrofitting of existing building. Steel braced frame is used to resist earthquake loads in multistoried buildings. Steel bracing systems are affordable, simple to install, take up less space and may be designed in a variety of ways to achieve the desired strength and stiffness. In this study, three different heights of building model were considered to analyze the effect of bracing systems. For the study, each model is considered to be different bracing system viz. X-bracing, diagonal bracing, inverted V-bracing, eccentric bracing. The bracing is provided for peripheral columns of each model. Using STAAD Pro software, the building models were analyzed for seismic zone IV according to IS 1893: 2002. According to the results, the X type of steel bracing significantly increases structural rigidity and reduces the maximum interstorey drift of the frames. Global and story drifts are used to analyze the building's performance.
Spinning Out Greentech Start-ups
Authors: Swetloff Adam
Published: December 2023

The Paris Agreement has made combating climate change a priority and has incentivised innovationfor the greentech industry. Higher education institution[s] (HEI[s]) play an important role in fueling this innovation by developing disruptive technologies and support the creation of start-up companies that take the risk to bring these technologies to the market. The successful spinning out of such start-ups relies on the HEIs nurturing anecosystem with multiple actors as well as internal mechanisms to transfer such technologies to the start-up. HEIs have dedicated offices involved in technology transfer (TTO) that provide an interface between all the different actors (inventors, founders, start-up, investors, etc.). The TTO of an HEI also plays a central role in the technology transfer by providing the licence agreements granting start-ups the rights to use a technology developed by the HEI. This review summarises the role of a TTO and the practice of making the licensing process as transparent as possible for start-up founders and investors.
Photochemical Upcycling/Modification of Polystyrene-based Plastic Waste
Authors: Qin Yuman , Das Shoubhik
Published: December 2023

The escalating accumulation of plastic waste in landfills and marine environments has become a pressing concern to society. Among all plastic-based waste, polystyrenes are widely utilized as a commodity plastic and present very low recyclability. To improve this scenario, photocatalysis has recently become one of the viable techniques which can be performed under mild conditions. In this concise review, we have highlighted recent advancements in the valorization of polystyrene-based plastic waste by mainly focusing on the selective functionalization of the C–H bonds. This strategy clearly holds strong promise for the sustainable and efficient conversion of polystyrene-based waste and contributes to the reduction of waste and resource conservation.
Significance of Plastic Recycling with the Focus on Polyesters – Creating a Circular Economy
Authors: Uran F. Pelin , Bila Hale , Shah Shaista , Hlaiem Mohamed , Valizadeh Bardiya , Anderson Samantha , Ireland Christopher
Published: December 2023

Plastics materials are essential in every part of our lives, resulting in their increasing production and consumption. Consequently, recycling of plastics has been of great importance in the last decades. Among all types of plastics, polyesters have become very appealing for numerous kinds of applications, making their recycling crucial. Several techniques have been developed for the recycling of plastics with the aim of eliminating the waste accumulated, as well as to create a circular economy.
Upcycling of Cereal Byproducts: A Sustainable Opportunity to Valorize Wasted Nutrients and Derive Bioactive Compounds for Humans and Animals Nutrition and Health
Authors: Nahi Ouassef , Siankevich Sviatlana
Published: December 2023

With the global population projected to reach close to 10 billion by 2050, the escalating demand for cereals such as wheat, rice, corn, oat, and barley places significant pressure on production systems. These systems are increasingly vulnerable to the adverse impacts of climate change, threatening global food security. This article emphasizes the critical need to address these challenges and explores strategies for sustainable foodproduction, focusing on the opportunities that the upcycling of cereal byproducts offers for human and animal nutrition and health.
Improved methods for determining the leaf surface index using unmanned aerial vehicles to determine the productivity of phytocenoses
Authors: Gumbatov D. A. , Danilov Yu. G.
Published: December 2023

In landscape and biogeographic studies, the assessment of the photosynthesis process, which affects the possibility of determining the productivity of phytocenoses, calculating the growth of phytomass, is of particular relevance. The use of unmanned aerial vehicles (UAVs) to evaluate the leaf surface index (LAI) is gaining more and more scope over time due to their low price, high operational efficiency and accuracy. The basis for determining LAI is a model for the slit fraction, theoretically estimated using the Bera-Booger-Lambert law. The possibility of determining the LAI of vegetation using a UAV, on board of which either a lidar or a multispectrometer can be installed, is analyzed. In the first problem, LAI is determined by calculating the logarithm of the slit function (fraction) multiplied by the cosine of the scanning angle and divided by the attenuation coefficient. The second problem uses the existing correlations between known vegetation indices and LAI. Empirical statistical regression models may be suitable for determining LAI after determining various vegetation indices. Based on the results of multispectral measurements, it was found that the LAI determination technique based on measuring the intensity of rays that passed through the crown of plants leads to highly noisy estimates. For this reason, it was decided to use the slit fraction (GF), while using the experimentally established fact that when multiplying the logarithm of the vegetation index by the height of the crown, this correlation is significantly enhanced. To increase the reliability of the obtained LAI values, it is proposed to use the average integral value of this indicator, calculated by composing and calculating an optimization variational problem containing an additional restrictive condition. At the same time, it is possible to solve both problems to the maximum, i.e. it becomes possible to increase the signal-to-noise ratio of the calculated value of the LAI index. In both optimization calculation procedures, there are generalized indicators that have different physical meanings.
Modeling the weight moisture content of soils in Anabar tundra using ground-based research and remote sensing data of the earth
Authors: Nikiforova N. N. , Kalinicheva S. V. , Fedorov A. N.
Published: December 2023

Presently, the climate is warming, with average annual temperatures rising every year, and the Arctic remaining one of the most vulnerable regions. This has a noticeable effect on the northern forests, which leads to the displacement of the tundra zone. Assessing the consequences of a projected increase in air temperature under climate change conditions requires spatial and instant monitoring of hard-to-reach areas. In the last few years, the use of remote sensing techniques and combinations of satellite imagery to calculate vegetation indices has generated great interest in obtaining high-definition ground data. The article presents the results of modeling soil moisture in Anabar tundra, which is located in the north-west of Yakutia.  The study was conducted on the border of tundra and forest tundra in three reference areas (tundra, tundra young forest, tundra indigenous forest). The simulation is presented by comparing the field data and the normalized difference index of humidity NDMI. The NDMI index uses the NIR and SWIR channels, calculates a multi-channel raster object and creates a raster image with index values from -1 to 1, which show the humidity level with a spatial resolution of 10 meters. The data showed that the value of humidity pixels according to NDMI in the tundra zone is 0.04, in the tundra young forest is 0.09 and, in the tundra, native forest is 0.15. It was found that the index data correlated with field humidity data obtained from a depth of 0.2 m. A comparison of remote sensing decryption data with field data made it possible to simulate the spatial distribution of soil moisture over the vast study area by extrapolation.
Introduction: Critical Notes on the Lived Karma Conference
Authors: Kerekes Susanne , Zu Jessica
Published: December 2023

No abstract available.
Sociokarma and Kindred Spirits: An Acknowledgement
Authors: Kerekes Susanne
Published: December 2023

Jonathan S. Walters’ sevenfold sociokarma typology considers only two broad categories of karma: that of an individual agent or that of an institution or social group. This brief study reframes Walters’ sociokarma away from agent-centered myopia to relation-centered analysis. With illustrations from the contemporary Thai religious landscape, we can observe how various forms of relational karma intuitively account for spirits and material objects as a given. In other words, “collective karma” must also address entanglements; Entanglements of not only individual agents, be they persons or institutions, but also of ancestors, ghosts, deities, and various material culture—an agency of relations. Hence, ultimately, this note calls for the acknowledgement of spirits and “stuff” as inclusive in conceptions of collective karma.
Integration of generative machine learning with the heuristic crystal structure prediction code FUSE
Authors: Collins Christopher M. , Sayeed Hasan M. , Darling George R. , Claridge John B. , Sparks Taylor D. , Rosseinsky Matthew J.
Published: December 2023

The prediction of new compounds via crystal structure prediction may transform how the materials chemistry community discovers new compounds. In the prediction of inorganic crystal structures there are two distinct classes of prediction; Performing crystal structure prediction via heuristic algorithms, using a range of established crystal structure prediction codes, and an emerging community using generative machine learning models to predict crystal structures directly. In this work, we demonstrate the use of a generative machine learning model to produce the starting population of crystal structures for a heuristic algorithm and discuss the benefits, demonstrating the method on eight known compounds with reported crystal structures and three hypothetical compounds. We show that the integration of machine learning structure generation to heuristic structure prediction results in both faster compute times per structure and leads to lower energies. This work provides to the community a set of eleven compounds with varying chemistry and complexity which can be used as a benchmark for new crystal structure prediction methods as they emerge.
Sphingomyelinase-responsive nanomicelles for targeting atherosclerosis
Authors: Muñoz-Hernando María , Nogales Paula , Fernández-Barahona Irene , Ruiz-Cabello Jesús , Bentzon Jacob F. , Herranz Fernando
Published: December 2023

Atherosclerosis, a leading cause of cardiovascular diseases requires approaches to enhance disease monitoring and treatment. Nanoparticles offer promising potential in this area by being customisable to target components or molecular processes within plaques, while carrying diagnostic and therapeutic agents. However, the number of biomarkers available to target this disease is limited. This study investigated the use of sphingomyelin-based nanomicelles triggered by sphingomyelinase (SMase) in atherosclerotic plaques. Accumulation of iron oxide-based nanomicelles in the plaque was demonstrated by fluorescence, MR imaging and electron microscopy. These findings demonstrate the possibility of utilising SMase as a mechanism to retain nanoprobes within plaques, thus opening up possibilities for future therapeutic interventions.
Scaffold-Oriented Asymmetric Catalysis: Conformational Modulation of Transition State Multivalency during a Catalyst-Controlled Assembly of a Pharmaceutically Relevant Atropisomer
Authors: Tampellini Nicolo , Mercado Brandon , Miller Scott
Published: December 2023

A new class of superbasic, bifunctional peptidyl guanidine catalysts is presented, which enable the organocatalytic, atroposelective synthesis of axially chiral quinazolinediones. Computational modeling unveiled the conformational modulation of the catalyst by a novel phenyl urea N-cap, that shape-shifts the structure into the active, folded state. A previously unanticipated noncovalent interaction involving a difluoroacetamide acting as a hybrid mono- or bidentate hydrogen bond donor emerged as a decisive control element inducing atroposelectivity. These discoveries spurred from a scaffold-oriented project inspired from a fascinating investigational BTK inhibitor featuring two stable chiral axes, and relies on a mechanistic framework that was foreign to the extant lexicon of asymmetric catalysis.
Molecular insights into the influence of ions on water structure. I. Alkali metal ions in solution
Authors: Savoj Roya , Agnew Henry , Zhou Ruihan , Paesani Francesco
Published: December 2023

In this study, we explore the impact of alkali metal ions (Li+, Na+, K+, Rb+, and Cs+) on the hydration structure of water using molecular dynamics simulations carried out with the MB-nrg potential energy functions (PEFs). Our analyses include radial distribution functions, coordination numbers, dipole moments, and infrared spectra of water molecules, calculated as a function of solvation shells. The results collectively indicate a highly local influence of all the alkali metal ions on the hydrogen-bond network established by the surrounding water molecules, with the smallest and most densely charged Li+ ion exerting the most pronounced effect. Remarkably, the MB-nrg PEFs demonstrate excellent agreement with available experimental data for the position and size of the first solvation shells, underscoring their potential as predictive models for realistic simulations of ionic aqueous solutions across various thermodynamic conditions and environments.
Exploring the Conformational Landscape of Poly(L-lysine) Dendrimers using Ion Mobility Mass Spectrometry
Authors: Wang Xudong , Benoit Florian , Dai Junxiao , Geue Niklas , Bristow Anthony , England Richard , Barran Perdita
Published: December 2023

Ion mobility mass spectrometry (IM-MS) measures the mass, size and shape of ions in the same experiment, and structural information are provided via collision cross section (CCS) values. The majority of commercially available IM-MS instrumentation relies on the use of CCS calibrants, and here we present data from a family of poly(L-lysine) dendrimers and explore their suitability for this purpose. In order to test these compounds we employed three different IM-MS platforms (Agilent 6560 IM-QToF, Waters Synapt G2 and a home-built variable temperature drift-tube IM-MS) and used them to investigate six different generations of dendrimers in two buffer gases (helium and nitrogen). Each molecule gives a highly discrete CCS distribution suggestive of single conformers for each m/z value. The DTCCSN2 values of this series of molecules (molecular weight: 330 - 16214 Da) range from 180 to 2940 Å2, which spans the CCS range that would be found by many synthetic molecules including supramolecular compounds as well as many biopolymers. The CCS values for each charge state were highly reproducible in day to day analysis on each instrument although we find some small systematic variations between instruments. The rigidity of each dendrimer was probed using collisionally activated as well as high-temperature IM-MS experiments, where no evidence for significant CCS change ensued. Taken together, this data indicates that these polymers are candidates for CCS calibration and could also help to reconcile differences found in CCS measurements on different instrument geometries.
Crystallization of n-alkanes under anisotropic nano-confinement in lipid bilayers
Authors: Wurl Anika , Ott Maria , Schwieger Christian , M. Ferreira Tiago
Published: December 2023

Understanding crystallization behaviour is integral to the design of pharmaceutical compounds for which the pharmacological properties depend on the crystal forms achieved. Very often, these crystals are based on hydrophobic molecules. One method for delivering crystal-forming hydrophobic drugs is by means of lipid nanoparticle carriers. However, so far, a characterization of the potential crystallization of fully hydrophobic molecules in a lipid environment has never been reported. In this work we investigate the crystallization behaviour of two model hydrophobic chains, n-eicosane (C20) and n-triacontane (C30), in phospholipid bilayers. We combine static 2H nuclear magnetic resonance (NMR) spectroscopy and differential scanning calorimetry (DSC) and show that C30 can indeed crystallize inside DMPC and POPC bilayers. The phase transition temperatures of C30 are slightly reduced inside DMPC, and rotator phase formation becomes a two-step process: Pre-organized n-alkane chains assemble in rotator-phase crystallites just as fast as bulk C30, but further addition of molecules is notably slower. Under the same isothermal conditions, different crystal forms can be obtained by crystallization in the membrane and in bulk. In excess water conditions, homogeneous nucleation of C30 is observed. The initial anisotropic molecular arrangement of C30 molecules in the membrane is readily re-covered upon reheating, showing reversibility. The shorter C20 molecules on the other hand become trapped in the DMPC membrane gel-phase upon cooling and do not crystallize. This work marks the first observation of the crystallization of hydrophobic chains inside a lipid bilayer environment. As such, it defines a fundamental starting point for studying the crystallization characteristics of various hydrophobic molecules in lipid membranes.
A Computational Workflow for Refining AF2 Models in Drug Design Using Kinetic and Thermodynamic Binding Calculations: A Case Study for the Unresolved Inactive human Adenosine A3 Receptor
Authors: Kolocouris Antonios , Stampelou Margarita , Ladds Graham
Published: December 2023

A drug design pipeline that considers both thermodynamic and kinetic binding data of ligands against a receptor will enable the computational design of improved drug molecules. Here we studied a congeneric set of ligands that bind to structurally unresolved G protein coupled receptor (GPCR), the inactive human adenosine A3 receptor (hA3R). We tested three available homology models from which two have been generated from experimental structures of hA1R or hA2AR and one model was a multi-state alpha-fold2 (AF2)-derived model. We then applied alchemical calculations with thermodynamic integration coupled to MD simulations (TI/MD) to calculate the experimental relative binding free energies, and residence time (τ)-random accelerated MD simulations (τ-RAMD) to calculate the relative residence times (RTs) for antagonists. While the TI/MD calculations produce for the three homology models good Pearson correlation coefficient, correspondingly, r = 0.74, 0.62, 0.67 and mean unsigned error (mue) = 0.94, 1.31, 0.81 kcal mol-1 the τ-RAMD method showed r = 0.92, 0.52 for the first two models but failed to produce accurate results for the multi-state AF2-derived model. Subsequent optimization of the AF2-derived model by re-orientation of side chain of R1735.34 located in the extracellular loop 2 (EL2), that blocks ligand’s unbinding, the computational model showed r = 0.84 for kinetic data and improved performance for thermodynamic data (r = 0.81, mue = 0.56 kcal mol-1). Overall, after refining the multi state-AF2 model with physics-based tools, we were able to show strong correlation between predicted and experimental ligand relative residence times and affinities, achieving a level of accuracy comparable to an experimental structure. The computational workflow used can be applied to other receptor so helping to rank candidate drugs in a congeneric series, enabling prioritization of leads with stronger binding affinities and longer residence times.