bluuebunny/crossref_metadata_2025 huggingface dataset:
Alman Alaca × Kıl melezi ve Saanen Irkı Keçilerde Anogenital Mesafenin Karekterizasyonu ve Fertilite ile İlişkisi
Authors: Kutlu Metehan , Durmuş Murat
Published: April 2024

Sunulan çalışmada, üreme mevsimi içerisinde östrüsları senkronize edilen Alman Alaca × Kıl melezi ve Saanen ırkı keçilerde anogenital mesafenin karekterizasyonu ve fertilite ile ilişkisi ortaya koymak amaçlanmıştır. Çalışmada 53 baş Alman Alaca x Kıl melezi (%75 Alman Alaca ve %25 Kıl keçisi) ve 55 baş Saanen ırkı keçi kullanıldı. Sünger uygulanmadan önce tüm keçilerin anogenital mesafeleri dijital kumpasla ölçülerek kaydedildi. Her ırk için kısa AGD grubu ve uzun AGD grubu olmak üzere iki AGD kategorisine ayrıldı. Bu keçilere 0. gün intravajinal 60 mg medroksiprogesteron asetat içeren sünger uygulandı, süngerler 13 gün süreyle vajinada tutuldu. Tüm keçilerde uygulamanın on üçüncü günü süngerler çıkarıldı ve sünger çıkarılması anında 500 IU dozda eCG uygulandı. Östrüs tespiti süngerlerin çıkartılmasından 12 saat sonra başlanarak sabah ve akşam 2 arama tekesinin sürüye katılması ile gerçekleştirildi. Östrüste olduğu tespit edilen keçiler elde aşım yöntemiyle (teke/keçi oranı: 1/7) fertil tekelerden bir tanesi ile çiftleştirildi. Teke katımından sonraki 40. günde çiftleşen hayvanlara ultrasonografik gebelik muayenesi yapıldı. Tüm gruplarda östrüs oranı, gebelik oranı, doğum oranı, çoklu doğum oranı, yavru verimi ve erkek yavru oranı parametreleri hesaplandı. Yapılan istatistiksel analiz sonrası gruplar arasında takip edilen parametreler arasında önemli bir fark saptanmadı (p>0,05). Sonuç olarak üreme mevsimi içerisinde progestagen uygulamaları ile östrüsları senkronize edilen Alman Alaca x Kıl melezi ve Saanen ırkı keçilerde anogenital mesafenin fertilite üzerine farklılık yaratmadığı görüldü. Keçilerde anogenital mesafenin karekterizasyonu ve fertilite ile ilişkisinin açıkça ortaya konulabilmesi için daha ayrıntılı çalışmalara ihtiyaç olduğu düşünülmektedir.
MEME INTEGRATION IN ENGLISH WRITING INSTRUCTION
Authors: Krisbiantoro Benny , Soali Muhammad
Published: April 2024

The research method for utilizing memes in English writing instruction involves several steps, beginning with the identification and selection of relevant memes aligned with learning objectives. These memes aim to foster creativity and enhance students' comprehension of English content. Following this, writing activities integrated with memes are designed and implemented to stimulate critical thinking and expression in diverse contexts. The method's effectiveness is evaluated by analyzing students' writing quality pre and post-meme incorporation, along with gathering feedback to assess its success in enhancing English comprehension. The findings highlight the significance of meme integration in engaging students effectively, stimulating creativity, and enhancing comprehension. Moreover, the memes consistently prompted improved critical thinking and expression among students in various contexts, contributing to enhanced language proficiency and originality. However, educators should curate memes thoughtfully to ensure relevance and educational value, with ongoing professional development crucial for maximizing the method's potential. In conclusion, meme integration has proven to be a dynamic pedagogical tool, enhancing student engagement, critical thinking, and writing skills, yet necessitating careful curation and continual educator development for its effective implementation.
STUDENTS’ PERCEPTION OF ENGLISH DAY AND SPEAKING SKILL AT ASH-SHIDDIIQI ISLAMIC BOARDING SCHOOL
Authors: Nurul Izzatil Ulya
Published: April 2024

The research aimed to investigate the impact of English Day on students' speaking skills in Islamic schools, using questionnaires to gather data on students' perceptions of English Day. The results showed that English Day positively affects speaking skills, with students strongly agreeing and agreeing that it is effective in familiarizing them with speaking English, providing wider opportunities to explore their language skills, and building their conceptual knowledge in English. The majority of students also agreed that learning activities in English Day are more effective in improving their English skills, and they can learn more optimally in the English Day program. The learning conditions on English Day were found to be more interesting compared to regular English classes, and students agreed that English learning on English Day is more contextualized through activities related to daily activities. The concept of reward and punishment in English Day was perceived as providing more motivation for students to improve their English skills. Based on the questionnaire results, the researcher concluded that 100 students contributed to English Day, and they gave a positive response or agreed that English clubs can support their speaking skills. The findings align with the benefits of joining extracurricular English clubs, as identified in previous research.
OPPORTUNITIES AND CHALLENGES IN IMPLEMENTING CO-CURRICULAR ACTIVITIES PERCEIVED BY TEACHERS AS FACILITATORS AT STATE VOCATIONAL SCHOOL 1 JAMBI CITY: A NARRATIVE INQUIRY
Authors: Putimasurai  , Nazurty  , Anggraini Desti , Aniswaty Maida
Published: April 2024

This study aims to give a general overview of the opportunities and difficulties the facilitators encountered at State Vocational School 1 Jambi City when implementing co-curricular activities. Using in-depth interviews and narrative inquiry as the research methodology, two English teachers who have been practicing P5 for two years were designated as the Facilitators. According to the findings, offering the P5 as a co-curricular has the ability to strengthen the school program, offer a more concentrated character development program, foster teacher collaboration, and raise student performance in terms of independence and creativity. One of the issues encountered during P5 implementation is locating references for P5 activity design and administration.
Educational Linguistics. A Dictionary
Authors: Balboni Paolo E.
Published: April 2024

This Open Access dictionary in Italian includes the main issues of educational linguistics, the research area which deals with language education, i.e. the teaching of the mother tongue and of second, foreign, classical end ethnic languages.
“Iturup 2022–2023” expedition: main directions of work and preliminary results
Authors:   Institute of Volcanology and Seismology of the Far Eastern Branch of RAS, Batanov Ph.I. , Abkadyrov I.F. ,   Institute of Volcanology and Seismology of the Far Eastern Branch of RAS, Degterev A.V. ,   Institute of Marine Geology and Geophysics of the Far Eastern Branch of RAS, Zakharov S.M. ,   Institute of Volcanology and Seismology of the Far Eastern Branch of RAS, Kokhanova S.P. ,   Trofimuk Institute of Petroleum-Gas Geology and Geophysics of the Siberian Branch of RAS, Novikov Yu.V. ,   Institute of Volcanology and Seismology of the Far Eastern Branch of RAS, Pinegina T.K. ,   Institute of Volcanology and Seismology of the Far Eastern Branch of RAS, Razjigaeva N.G. ,   Pacific Geographical Institute of the Far Eastern Branch of RAS, Khomchanovsky A.L. ,   Institute of Volcanology and Seismology of the Far Eastern Branch of RAS, Khubaeva O.R. ,   Institute of Volcanology and Seismology of the Far Eastern Branch of RAS
Published: April 2024

The paper provides information on the objectives, methods, targets and some preliminary results of the expeditionary work carried out within the framework of the RSF project No.21-17-00049 by the employees of the Institute of Volcanology and Seismology of the FEB RAS, Institute of Marine Geology and Geophysics of the FEB RAS, Pacific Geographical Institute of the FEB RAS and Trofimuk Institute of Petroleum-Gas Geology and Geophysics of the SB RAS in 2022 and 2023. The main objectives of the expedition were geological-volcanological, hydrogeological, geophysical, tephrochronological, and paleoseismological studies. In accordance with the set objectives, field teams were formed, which began work in February 2022. On the basis of the data obtained during the expedition, previously unknown hydrothermal manifestations and seismic events on Iturup Island were identified. A number of geophysical and paleomagnetic surveys were carried out.
Sistem Informasi Penjualan Seprai Pada Toko Salsabila Seprai
Authors: Syidada Shofiya , Anggraini Herlina Putri
Published: April 2024

Technological developments are needed in carrying out various sales activities. Currently, it has become a necessity that information technology can provide convenience in finding the desired information. Toko Salsabila Seprai started running its business through the Instagram platform but there were various problems such as the lack of monitoring of the transaction process and transaction reports which were still done manually because the sales system was not integrated. Therefore, the purpose of this research is to develop a website-based sales information system using the SDLC method. This system is used by the Salsabila Store as a media for sales and transaction data management. The design of this sales information system uses a structured method. Website implementation is made using the HTML, PHP and MySQL programming languages and using the Bootstrap framework so that the web appearance becomes responsive and attractive. The results obtained are a website-based bed sheet sales information system application that is equipped with main page menu features, login, customer registration, shopping cart, purchases, payments, sales reports and admin pages for data management. Based on the test results using the blackbox method, these features can function properly and are valid.
ANALISA PENGUKURAN KUALITAS APLIKASI GOJEK DENGAN METODE WEBQUAL 4.0
Authors: Muhammad Bima Nugroho
Published: April 2024

Berdasarkan ulasan pada Google Play Store pada aplikasi Gojek, kendala-kendala tersebut meliputi kesalahan teknis pada aplikasi, kesulitan dalam mencari driver atau merchant terdekat, perhitungan biaya atau tarif, masalah pada layanan pelanggan, kecurangan atau penipuan yang dilakukan oleh driver atau merchant, keamanan dan privasi data pengguna yang tidak terjaga dengan baik, ketidaknyamanan dalam penggunaan aplikasi.Data yang telah dikumpulkan akan dipresentasikan dalam bentuk instrumen kuesioner menggunakan skala likert untuk pengukuran kualitas aplikasi Gojek. Kuesioner dibuat untuk memperoleh jawaban responden dengan memberikan pilihan alternatif jawaban yang memudahkan mereka. Kuesioner ini berfokus pada tiga dimensi Webqual 4.0, yaitu usability, information quality, dan service interaction quality. Peneliti melakukan proses pengolahan data dengan menggunakan perangkat lunak SPSS. Analisis kesenjangan, nilai positif sebesar 0,07. Nilai Performance tertinggi sebesar 4,18 adalah X1_2, Hal ini menunjukkan aplikasi Gojek memiliki dampak positif yang signifikan terhadap pengguna. Sedangkan nilai Performance rendah sebesar 3,69 adalah X3_3. Analisis metode webqual 4.0, ditemukan bahwa nilai signifikan sebesar .001, lebih kecil dari probabilitas 0.05, terdapat pengaruh yang signifikan antara kinerja aplikasi Gojek dengan kepentingan pengguna. Hasil penelitian ini dapat menjadi referensi meningkatkan kualitas Gojek. Pengembangan selanjutnya difokuskan pada aspek kualitas informasi, mengenai tingkat detail informasi yang tepat dan akurat. Perusahaan disarankan untuk mempertimbangkan rekomendasi berikut: 1. Meningkatkan kualitas informasi untuk konsumen. 2. Mengoptimalkan tampilan Gojek agar lebih menarik. 3. Menyediakan peningkatan diskon untuk menarik konsumen. 4. Menjaga komunikasi yang efektif dengan pengguna Gojek.

Kata Kunci: Gojek, Webqual 4.0, Konsumen, Kualitas.
Professor Carla Bottoli, an enthusiastic scientific researcher, kindly spoke to BrJAC
Authors: Bottoli Carla
Published: April 2024

Carla Beatriz Grespan Bottoli holds a degree in Industrial Chemistry from the Federal University of Santa Maria (1996), as well as a Ph.D. in Chemistry (2002), and a postdoctoral degree in Chemistry (2002-2004), both from the State University of Campinas (Unicamp). In 2005, she undertook an internship at the Institute of Nuclear Sciences of the National Autonomous University of Mexico (UNAM) to study radiolysis in vitamins using gamma radiation from a source of Cobalt 60. In 2017, she presented her habilitation thesis (associate professor's thesis) at Unicamp. Currently, she is Associate Professor and Postgraduate Advisor at the Institute of Chemistry at Unicamp (IQ-Unicamp), where she works in the area of analytical chemistry, with emphasis on separation methods, mainly liquid chromatography. Prof. Bottoli coordinates the NovaCrom – Liquid Chromatography Laboratory (https://novacromlab.wixsite.com/novacrom), which is a research group that has been working on the development of new monolithic stationary phases for capillary liquid chromatography. Research is also focused on the development of analytical methods that employ liquid chromatography coupled with mass spectrometry to study the translocation of pesticides in plants such as coconut, palm, and soybean. Between 2019 and 2021, Prof. Bottoli was an associate coordinator of the Research Commission of the IQ-Unicamp and is currently a member of the Research Integrity Commission at Unicamp. She is a member of the Brazilian Chemical Society and a researcher at the National Institute of Science and Technology in Bioanalytics (INCTBio). Carla Bottoli is the mother of Murilo, 13 and Mateus, 10.
Current Information on the Safety of Medicinal Products: Decisions of Foreign Regulatory Authorities
Authors: Shubnikova E. V.
Published: April 2024

The experts of the Department for Medicine Safety Evaluation of the Scientific Centre for Expert Evaluation of Medicinal Products analysed administrative decisions of international pharmacovigilance regulatory authorities on the necessary labelling updates. The analysis revealed 16 decisions containing safety updates for the following medicines registered in Russia: avatrombopag, amphotericin B, acetazolamide, belimumab, bendamustine, hydrocortisone, dabrafenib, dexamethasone, denosumab, ibuprofen, cortisone, prednisolone, trametinib, nilotinib, pirfenidone, and cefotaxime.
ABDOME AGUDO CAUSADO POR PARACOCCIDIOIDOMICOSE: UM RELATO DE CASO
Authors:   Hospital Carlos Fernando Malzoni, Gabriele Zambon Lais , Barcha Santos Carolina , Ortega Fernandes Ana Clara , Salomão Remédio Flávia , Orlandi de-Souza Gabriel , Henrique de-Albuquerque Victoria ,   Universidade de Araraquara
Published: April 2024

Introdução: A paracoccidioidomicose (PCM) é uma doença rara, causada por fungos termodimórficos das espécies Paracoccidioides brasiliensis e P. lutzii, sendo os maiores fatores de risco para aquisição da infecção a atuação em profissões de manejo agrícola, o tabagismo e o alcoolismo. É mais prevalente no sexo masculino, de curso insidioso e acometimento multissistêmico, sendo comum o comprometimento respiratório, dermatológico e adrenal, associado a linfadenomegalias. Relato do caso: Trabalhador agrícola, 20 anos, com história de linfadenopatia generalizada com evolução de 3 meses, progredindo para um abdome agudo cirúrgico devido necrose de linfonodos mesentéricos. Conclusão: A PCM é uma doença de difícil diagnóstico muitas vezes fatal, sendo uma das principais causas de morte por doenças infecciosas e parasitárias no Brasil. É de suma importância a anamnese completa, história pregressa, exame físico geral completo do paciente, bem como a educação continuada dos profissionais de saúde de áreas endêmicas sobre a PCM, tendo em vista seu grande polimorfismo de quadro clínico, que podem variar desde a sintomatologias clínicas a emergências cirúrgicas. Palavras-chave: Paracoccidioidomicose. Linfadenopatia. Abdome Agudo.
Presentación tardía de hernia diafragmática traumática con necrosis gástrica: revisión de la literatura científica
Authors: Beltrán Marcelo A.
Published: April 2024

La hernia diafragmática complicada de presentación tardía constituye una urgencia quirúrgica debido a la isquemia y eventual necrosis y gangrena de los órganos herniados. Los órganos o estructuras que se encuentran con mayor riesgo de sufrir complicaciones por la hernia son el colon, el estómago, el bazo, el epiplón mayor y los intestinos. La necrosis y gangrena del estómago se deben a su estrangulamiento dentro de la hernia, lo que constituye una complicación grave y potencialmente mortal. El presente artículo resume brevemente la literatura científica relevante sobre el diagnóstico clínico y radiológico, y el tratamiento de la necrosis gástrica como complicación de la hernia diafragmática de presentación tardía.
Porokeratosis in different age groups: from clinical manifestations to features of patient management (clinical cases)
Authors: Makurina H.I. , Cherneda L.O. , Kalmykova A.V.
Published: April 2024

Objective — to analyze the clinical manifestations of porokeratosis among patients of different age groups with emphasis on diagnostic possibilities; determine the potential risk of malignant transformation of dermatosis; choose the optimal therapeutic tactics.
Materials and methods. Personal observations of clinical manifestations of porokeratosis in representatives of the adult and children’s population are described. The diagnosis based on the assessment of visual manifestations of dermatosis was verified at the department of dermatovenerology and cosmetology with a course of dermatovenerology and aesthetic medicine of the Zaporizhzhya State Medical and Pharmaceutical University. In addition, a dermatoscopy was performed at the «University Clinic» Educational and Scientific Center. Pathomorphological diagnosis is recognized as the final argument in diagnosis and the choice of further treatment tactics.
Results and discussion. The first clinical case in a patient born in 1961 is represented by a pathological process in the form of papular plaque elements located along Blashko’s lines on the left thigh and the upper third of the lower leg. Single «islets» of the skin with more pronounced inflammation, infiltration, nodule formation, and the appearance of serous hemorrhagic exudate with local ulceration were recognized as clinically suspicious. For the second clinical case in a patient born in 2014 the presence of plaques with clear borders and hyperkeratotic changes on the skin of the left lower limb was characteristic. Dermatoscopic pathomorphological diagnosis in both cases provided not only verification of the diagnosis, but also disproved the suspicion of a possible malignant transformation in the lesions. The appointment of systemic retinoids in the first case and their topical form in the second case was based on the principles of a personalized approach with an assessment of the age characteristics and somatic background of the patients.
Conclusions. When examining rare dermatological nosologies, clinical­dermatoscopic­morphological correlation plays the most important role in the timely and correct diagnosis of dermatosis. During the clinical examination of patients with porokeratosis of various ages, the practitioner should be alert to the formation of malignant transformation within the primary lesions, considering any dynamic changes as potentially suspicious. When developing an individual therapeutic algorithm, it is necessary to take into account not only the links of the pathogenetic mechanisms of the formation of porokeratosis but also age, social, and background comorbid conditions.
Topical retinoids: role and place in acne therapy
Authors: Bolotna L.A.
Published: April 2024

Retinoids are derivatives of vitamin A that have a pleiotropic (multiple) effect on cell differentiation, proliferation, and apoptosis. Topical retinoids alone or in combination with other agents have been used in the topical treatment of acne for more than half a century. The biological effects of retinoids are mediated and regulated by cytosolic binding proteins and nuclear receptors of retinoic acid and retinoid X-receptor. At the same time, the expression of cellular proteins changes, which affects numerous pathways involved in the pathogenesis of acne — a chronic inflammatory disease of the sebaceous hair follicle. Retinoids have evolved from first-generation drugs such as tretinoin and isotretinoin through chemical modifications, which led to the creation of second-generation (etretinate and acitretin for the treatment of psoriasis), third-generation (adapalene and tazarotene) and recently fourth-generation (tripharotene) products.Topical retinoids are central to the treatment of patients with acne, being the first-line treatment for mostly comedonal acne, and in combination with antimicrobial agents — for mostly mild to moderate papulopustular acne. The advantages of adapalene 0.1 % gel and its combination with an antimicrobial agent (clindamycin 1 %) in topical treatment, the importance of modern technologies for the delivery of active substances in retinoids are presented. Adapalene and fixed combinations of anti-acne agents have gained leading role not only in initial (induction) but also in maintenance treatment due to rapid onset and long duration of action, favorable safety/tolerability profile. Attention was paid to the effectiveness and good tolerability of the drugs Deriva (adapalen 0.1 % gel), Deriva C (adapalen 0.1 % and clindamycin phosphate 1 %), Deriva C MS (adapalen micronized 0.1 % in microspheres and clindamycin phosphate 1 %), available today for the treatment of acne. Quick action and better tolerability of Deriva C MS gel improves patient adherence to therapy.
Varicose eczema: pathogenetic and clinical-pathological aspects. New treatment paradigms with the use of modern venotonic drugs
Authors: Lytynska T.О. , Razdaibiedin S.M. , Kopach V.V.
Published: April 2024

Objective — to analyze current perspectives on the pathogenesis, clinical course characteristics, diagnosis, therapeutic methods for patients with varicose eczema (VE) and to identify further research prospects that will enhance treatment efficacy for the dermatosis in question.
Materials and methods. Based on a review of the state-of-the-art literature and our own preliminary investigations, we identified the relevance of deeper investigation of the clinical course details of the varicose eczema and the development of therapy incorporating venotonic drugs in the comprehensive treatment.
Results and discussion. Varicose eczema manifests as a chronic relapsing condition occurring alongside chronic venous insufficiency, predominantly affecting the lower extremities and impacting up to 20 % of patients aged over 70. The appointment of venotonic agents to VE patients which improve venous microcirculation and lymphatic drainage, as well as slow down the processes of endothelial dysfunction, thereby increasing the effectiveness of treatment and reducing the likelihood of relapses, is pathogenetically justified.The drug of choice for inclusion in the complex therapy of patients with VE is a modern venotonic agent of combined action Flego®, which includes an ultramicronized fraction of bioflavonoids.
Conclusions. Further studies of the mechanisms of development and progression of VE will expand the understanding of the pathogenesis and contribute to the optimization of the therapy of this dermatosis.The appointment of venotonic agents is a pathogenetically justified approach to the treatment of patients with VE.The effectiveness and safety of the venotonic agent of combined action Flego® allows to recommend it for inclusion in the complex treatment schemes of patients with VE.
Insulin resistance and chronic inflammatory dermatoses
Authors: Bolotna L.A. , Sarian O.I. , Yemchenko Ya.O.
Published: April 2024

Recently, the impact of insulin resistance (IR) on the possibility of increasing the risk of skin diseases has attracted increasing attention of scientists. The causes of comorbid conditions have not been finally clarified. Determining the role of IR in the mechanism of development of dermatoses can affect the diagnosis and effectiveness of treatment.
Objective — to analyze literary sources that highlight research on the relationship between IR and some diseases of the skin and its appendages, as well as to find out possible mechanisms of interaction.
Materials and methods. The literature search was carried out using key words (IR, psoriasis, acne, adult acne, androgenetic alopecia, pathogenesis), sources from the databases of V.I. Vernadskyi National Library of Ukraine, PubMed, Web of Science and Scopus. Preference was given to sources published in the last 5 years.
Results and discussion. The literature review presents a specific and possible relationship between the development of psoriasis, acne vulgaris, acne tarda, androgenetic alopecia and IR based on updated data. IR is considered as a disturbed biological response of the body’s peripheral tissues (muscle, fat, and liver) to the influence of endogenous or exogenous insulin. Analysis of the literature proved that patients with chronic dermatoses have a high risk of developing IR. There are multiple molecular factors responsible for the close association of IR with the metabolic syndrome. Adipokines play a key role in both conditions.
Conclusions. IR is an important independent factor in the development of many inflammatory skin diseases, acting both independently and through associated metabolic disorders. It has been established that excess body weight and obesity are significantly associated with IR and the adverse course of dermatoses, so it is advisable for patients to determine HOMA­IR. The severity of chronic inflammatory dermatoses (psoriasis, adult acne, and AGA) is considered an independent predictor of IR.
ANALYSIS OF FACTORS ASSOCIATED WITH THE IMPLEMENTATION OF SEX EDUCATION AMONG ELEMENTARY SCHOOL CHILDREN IN RURAL AREAS
Authors: Lasiyati Yuswo Yani
Published: April 2024

Early sex education for children is very important to prevent sexual violence, but many parents believe that sex education for children is taboo. This research aims to find out what factors are related to parents' sex education practices for elementary school children. This research was conducted at Rural area. This research is descriptive analytical with a cross sectional approach. The population in this study were parents of students. The sample was selected using a purposive sampling method resulting in 171 respondents. Data collection uses a questionnaire. The data analysis SPSS.  The conclusion of this research, factors related to the implementation of parental sex education for elementary school children the first factor is parents' education and age, the second factor is parents' knowledge, and the third factor is parents' experience. The parents will increase information about early sex education for children, so that parents have good knowledge about sex education.
MEMBANGUN PARIWISATA: ADOPSI KEARIFAN LOKAL MASYARAKAT DUSUN BUTUH UNTUK PARIWISATA NEPAL VAN JAVA
Authors:   Program Studi Ilmu Administrasi Negara, FISIPOL, Universitas Tidar, Mulyani Sri , Fadlurrahman Fadlurrahman , Mukti Ari ,   Program Studi Ilmu Administrasi Negara, FISIPOL, Universitas Tidar,   Program Studi Ilmu Administrasi Negara, FISIPOL, Universitas Tidar
Published: April 2024

Penelitian ini bertujuan untuk mengkaji pengadopsian kearifan lokal masyarakat Dusun Butuh untuk pengembangan pariwisata Nepal van Java. Dusun Butuh mengalami lonjakan kunjungan wisatawan yang sangat signifikan mulai dari bulan Agustus hingga Desember tahun 2020. Fenomena tersebut dikarenakan viralnya Dusun Butuh di media sosial dan disebut sebagai Nepal van Java. Namun dibalik euforia kunjungan wisatawan ke Dusun Butuh, ada unsur lain yang menjadikan Dusun Butuh dikenal sebagai Nepal van Java, yakni pengadopsian kearifan lokal masyarakat. Penelitian ini menggunakan metode kualitatif deskriptif dengan pengumpulan data secara FGD, wawancara mendalam, observavsi, dan dokumentasi. Dari hasil penelitian, ditemukan bahwa Dusun Butuh berhasil mengelola dan mengadopsi kearifan lokal yang mereka miliki yang dapat ditinjau dari adaptasi masyarakat dengan lingkungan yang berada dibawah kaki Gunung Sumbing. Selain itu, pengetahuan dan kelembagaan lokal memberikan kontribusi terhadap pengembangan wisata Nepal van Java
KIPRAH FILSAFAT HUKUM PADA PENDIDIKAN HUKUM DI ERA KECERDASAN BUATAN (ARTIFICIAL INTELLIGENCE)
Authors:   Manchester University, Kurniawan Aditya Putra , Triantono Triantono ,   Universitas Tidar, Indonesia, Marizal Muhammad ,   Universitas Tidar, Indonesia
Published: April 2024

Tulisan ini bertujuan untuk mengkaji tentang kiprah filsafat hukum khususnya pada pendidikan hukum di era kecerdasan buatan (artificial intelligence). Menurut penulis hal ini menarik untuk dianalisis berhubungan dengan adanya narasi yang kuat serta dikotomis berkaitan dengan kontribusi Pendidikan tinggi hukum khususnya di era kecerdasan buatan (artificial intelligence) sebagai dampak dari era disrupsi. Dikotomisasi yang dimaksud berhubungan dengan proses maupun produk dari Pendidikan hukum yang mengarah pada keahlian professional praktik atau pada kearifan dan kebijaksanaan. Kendati secara idel dua hal tadi tidak bisa dipisahkan, namun narasi dikotomis itu terasa menguat seiring dengan adanya revolusi indusitri 4.0. Kondisi ini seolah menghasilkan sekat antara filsafat hukum dan Pendidikan Hukum. Melihat daripada itu, maka ada 2 (dua) permasalan yang akan dikaji, yaitu: 1) Eksistensi filsafat hukum di era Kecerdasan Buatan; 2). Relevansi filsafat hukum pada Pendidikan hukum di Era Kecerdasan Buatan (Artifisial Intelligence). Dengan menggunakan penelitian kepustakaan persoalan tersebut akan dianalisis sehingga menghasilkan diskripsi analitis tentang kiprah filsafat hukum pada Pendidikan hukum di era kecerdasan buatan (artificial intelligence). Hasil penelitian menunjukan bahwa filsafat hukum tetap eksis sebagai basis moral atau etika dan keadilan di era penegakkan hukum menggunakan kecerdasan buatan (artificial intelegence). Filsafat hukum dapat berperan dalam mengakhiri dikotomi dari suatu pendidikan hukum melalui internalisasi nilai kepastian, keadilan dan kemanfaatan sehingga keberadaan hukum dapat menghadirkan kesejahteraan manusia berlandaskan moral dan keadilan ditengah era kecerdasan buatan (Artificial Intelligence).
MAKNA PERLUASAN ALAT BUKTI ELEKTRONIK (ANALISIS PUTUSAN MAHKAMAH KONSTITUSI NOMOR 20/PUU-XIV/2016)
Authors:   Jurusan Hukum Universitas Tidar, Indonesia, Gunawan Tri Agus , Bhakti Indira Swasti Gama ,   Jurusan Hukum Universitas Tidar, Indonesia
Published: April 2024

Merujuk pada Pasal 184 Kitab Undang-undang Hukum Acara Pidana (KUHAP) telah dijelaskan bahwa alat bukti yang diakui dalam peradilan Pidana adalah alat bukti saksi, ahli, surat, petunjuk dan keterangan terdakwa. Alat bukti ini diakui di Indonesia sejak tahun 1981 ketika KUHAP ini disahkan sebagai Undang-undang. Berjalannya waktu alat bukti yang ada kurang bisa membuktikan kebenaran materil terkait kasus-kasus baru, salah satunya adalah kasus dengan memanfaatkan teknologi informasi. Kemajuan dalam perihal pembuktian, muncul bersamaan dengan terbitnya Undang-undang Nomor 11 Tahun 2011 Tentang Informasi dan Transaksi Elektronik. Pada pasal 5 dan pasal 44 telah diakuinya munculnya alat bukti baru yaitu alat bukti Informasi Elektronik dan Dokumen Elektronik. Munculnya alat bukti baru ini diakui sebagai bentuk perluasan dari alat butki yang ada pada peraturan perundang-undangan atau dalam hal ini adalah KUHAP. Namun permasalahan muncul tidak dijelaskannya maksud dari perluasan pada pasal 5 dan pasal 44 tersebut. Apakah itu menjadi alat bukti berdiri sendiri setelah lima alat bukti yang ada, atau masuk menjadi bagian dari alat butki yang sudah ada. Selain itu masalah yang lain adalah ketika pasal ini pernah digugat kepada Mahkamah Konstitusi dengan munculnya putusan Nomor 20/PUU-XIV/2016. Pada putusan tersebut telah merubah arah kebijakan, aspek filosofis dan juga tujuan dari pasal 5. Hipotesis sementara yang terbangun adalah ketika melihat isi pertimbangan putusan tersebut. Dalam pertimbangan terdapat beberapa hal yang mengalami kerancuan antara posisi informasi elektronik dan dokumen elektronik tersebut sebagai barang bukti atau alat bukti. Berdasarkan putusan mahkamah konstitusi tersebut juga terjadi pemaknaan berbeda cara bagaimana memperleh bukti elektorinik secara sah. Dalam praktik hal ini menimbulkan perdebatan baik di masyarakat bahkan hingga antara apart penegak hukum sendiri. Penelitian ini menggunakan penelitian normatif dengan menggunakan studi kepustakaan dengan sumber hukum primer yang digunakan adalah Undang- undang Nomor 11 Tahun 2011 Tentang Informasi dan Transaksi Elektronik. Selain itu data empiris berupaa wawancara juga kami butuhkan sebagai penunjang dari data primer yang dianalisis. Target khusus dari penelitian ini adalah untuk memberikan sumbangan keilmuan khususnya terkait pemikiran kritis terhadap undang-undang informasi dan trasnsaksi elektronik. Sedangkan tujuan jangka panjang adalah besar harapan penelitian ini dapat menjadi pertimbangan para pengambil kebijakan atau pembuat regulasi untuk melakukan perbaikan terhadap undang-undang ini sehingga tidak memberikan multi tafsir dalam tahap implemntasinya.
PEREMPUAN, JILBAB, DAN MAYORITARIANISME AGAMA SEKOLAH NEGERI DALAM PERSPEKTIF HAM
Authors:   Universitas Negeri Gorontalo, Indonesia, Mustika Waode , Nasiru La Ode Gusman ,   Universitas Negeri Gorontalo, Indonesia, Hasima Rahman ,   Universitas Halu Oleo
Published: April 2024

Perempuan dan jilbab adalah dua hal yang tidak terpisahkan dalam negara yang mayoritas penduduknya adalah muslim. Jilbab menjadi identitas dan simbol keislaman bagi perempuan muslim sebagai bagian dari kelompok mayoritas Indonesia. Surat Keputusan Dirjen Pendidikan Dasar dan Menengah No.100/C/Kep/D/1991 yang membolehkan para siswi mengenakan pakaian yang didasarkan pada keyakinannya menjadi dasar patokan penggunaan jilbab di lembaga pendidikan. Sejak saat itu, laju pemakaian jilbab mengalami peningkatan. Beberapa sekolah negeri bahkan ada yang mewajibkan semua siswi, baik yang muslim maupun non-muslim, untuk memakai jilbab. Tindakan intoleransi salah satunya dilatarbelakangi oleh faktor sentimen mayoritarianisme yang selanjutnya menjadi tirani. Tulisan ini bertujuan untuk mengetahui sejauh mana negara menjamin hak individu warga negaranya dalam keberagamaan dan juga untuk mengetahui bagaimana perempuan dan jilbab dalam relasinya dengan kebebasan ekspresi individu dalam perspektif HAM. Tulisan ini menggunakan metode penelitian hukum normatif berdasarkan kerangka hukum hak asasi manusia. Hasil studi menunjukkan bahwa jaminan negara terhadap hak individu warga negaranya dalam keberagamaan tertuang dalam dokumen HAM internasional, UUD 1945 Pasal 28e dan hak ini merupakan hak yang tidak dapat dikurangi dalam keadaan apapun. Jilbab sejatinya adalah kewajiban bagi setiap perempuan muslim akan tetapi dalam konteks HAM, jilbab adalah bentuk kebebasan ekspresi keagamaan yang wajib dihormati.
JAMINAN PERLINDUNGAN HAK DAN AKSES KEADILAN BAGI PEREMPUAN DAN ANAK PASCA PERCERAIAN (Analisis Komparatif Sistem Peradilan di Indonesia, Australia, dan Malaysia)
Authors:   Pascasarjana Universitas Jenderal Soedirman, Miftah Mokhamad
Published: April 2024

Artikel ini bertujuan guna mendapatkan informasi mengenai jaminan perlindungan hak-hak perempuan dan anak pasca perceraian sebagaimana peraturan perundang-undangan Indonesia. Penulisan ini menggunakan metode penelitian yuridis-normatif, yaitu studi hukum literatur dengan mengkaji bahan dari literatur atau data sekunder, dengan menggunakan pendekatan perundang-undangan. Hasil studi menunjukan hak-hak perempuan pasca perceraian di Indonesia, meskipun telah banyak regulasi terkait pemenuhan hak-hak perempuan dan nafkah anak pasca perceraian, yang dalam prakteknya belum dilakukan secara maksimal yaitu masih sebatas keadilan di atas kertas. Dengan mengkomparasikan sistem perlindungan hak-hak perempuan dan nafkah anak pasca perceraian pada sistem Family Court of Australia dan sistem Peradilan Malaysia, yang telah melakukan upaya intervensi sangat intens dan terstruktur dalam melakukan perlindungan terhadap hak-hak perempuan dan anak pasca perceraian. Family Court of Australia dan Jabatan Kehakiman Syariah Malaysia meskipun memiliki perbedaan sistem hukum yang menjadi rujukan dalam menangani perkara perceraian, namun dari perbedaan kedua negara tersebut diharapkan dapat diperoleh acuan teknis pelaksanaan putusan yang berkekuatan hukum tetap dalam memenuhi hak-hak perempuan dan anak pasca perceraian di Indonesia.
QUO VADIS KEBIJAKAN DATA PRIBADI DI INDONESIA: PENORMAAN LEMBAGA PENGAWAS
Authors:   Fakultas Hukum Universitas Udayana, Indonesia, Aryani Nyoman Mas , Hermanto Bagus ,   Fakultas Hukum Universitas Udayana, Indonesia
Published: April 2024

Artikel ini akan berfokus pada sebuah konsep dalam kebijakan data pribadi yang memberikan perlindungan terhadap masyarakat, dengan mengkajinya dari perspektif Hak Asasi Manusia. Kemajuan teknologi khususnya dunia maya atau cyber yang tentunya membawa perubahan positif bagi kemajuan umat manusia dan sudah menjadi sebuah kebutuhan di era digital seperti saat ini, namun juga tidak dapat dipungkiri terdapat dampak negatif yang menghancurkan kehidupan manusia. Perlindungan data pribadi menjadi bagian dari hak asasi manusia yang merupakan hak privasi dimana hukum yang berlaku secara internasional menetapkannya sebagai hak yang harus dilindungi. Artikel penelitian hukum normatif ini menggunakan pendekatan peraturan perundang-undangan, konseptual, perbandingan dan kasus terkait penyalahgunaan data pribadi. Hasil dan rekomendasi yang dapat diajukan terkait perlindungan, Indonesia belum mengatur perlindungan penanggulangan penyalahgunaan data pribadi secara khusus dalam sebuah undang-undang melainkan masih diatur secara terpisah di beberapa undang-undang. Untuk itu diperlukan sebuah formulasi kebijakan tata kelola data yang baik dan pengawasan yang ketat sehingga mampu melindungi masyarakat dari kejahatan siber.
Public Understanding of The Mechanism for Administering State Administrative Courts as a Form of Legal Protection
Authors:   Universitas Tidar, Indonesia, Marsheila Wiwin , Hakim Sholihul ,   Universitas Tidar, Indonesia
Published: April 2024

Legal relations in social life are part of the process after the emergence of a legal action originating from the legal subject itself. Legal action is the beginning of the birth of legal relations (rechtsbetrekking), namely interactions between legal subjects that have legal relevance. One of them is the relationship between the government and citizens. The government, as an executor (public servant), obtains broad authority in carrying out government affairs (Constitutional Mandate). This authority is likely to be abused, causing harm and injustice (Power Tends Corrupt, Absolute Power Corrupts Absolutely). The State Administrative Court is present as an institution that provides legal protection to the justice-seeking public related to administrative law (Administrative Law). This court has a tiered system starting from the first level, the appeal level, and the final level or cassation. The legal issues that will be discussed in this paper concern phenomena in the administration of the State Administrative Court in Indonesia, such as the court process, the basis for a lawsuit addressed to the government, and the mechanism in the State Administrative Court.
Distribution of Inheritance Property Before The Testator Dies: A KHI and Civil Law Perspective in Indonesia
Authors:   UIN Sunan Kalijaga, Indonesia, Riskis Rahmat
Published: April 2024

This research examines the practice of distributing inheritance before the testator dies from the perspective of the Compilation of Islamic Laws (KHI) and the civil law that applies in Indonesia. The problem studied in this research is the practice of distributing inheritance before the testator dies and whether such distribution is permitted according to KHI and civil law in Indonesia. This research applied literature review methodology that used a normative approach. The result shows that the practice of distributing inheritance before the testator dies according to KHI and civil law in Indonesia is not permitted, because the death of the testator is an absolute requirement for the distribution of inheritance. However, KHI provides an alternative for heirs to appoint someone as the person who will divide the inheritance after the testator dies. Concerning on civil law in Indonesia, it is stated that the distribution of inheritance while the testator is still alive cannot be carried out as it has no legal force and its status is null and void.
Microvascular Perfusion Imaging in Alzheimer's Disease
Authors: Song Yi , Xing Hang , Zhang Zhiqi
Published: April 2024

Alzheimer’s disease (AD) is the leading cause of dementia worldwide and significantly impacts the essential functions of daily life and social activities. Research on AD has found that its pathogenesis is related to the extracellular accumulation of amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles in the cortical and limbic areas of the human brain, as well as cerebrovascular factors. The detection of Aβ or tau can be performed using various probes and methodologies. However, these modalities are expensive to implement and often require invasive procedures, limiting accessibility on a large scale. While magnetic resonance imaging (MRI) and computed tomography (CT) are generally used for morphological and structural brain imaging, they show wide variability in their accuracy for the clinical diagnosis of AD. Several novel imaging modalities have emerged as alternatives that can accurately and vividly display the changes in blood flow and metabolism in each brain area and enable physicians and researchers to gain insights into the generation and progression of the cerebro-microvascular pathologies of AD. In this review, we summarize the current knowledge on microvascular perfusion imaging modalities and their application in AD, including MRI (dynamic susceptibility contrast-MRI, arterial spin labeling-MRI), CT (cerebral CT perfusion imaging), emission computed tomography (positron emission tomography (PET), single-photon emission computed tomography (SPECT)), transcranial doppler ultrasonography (TCD), and retinal microvascular imaging (optical coherence tomography imaging, computer-assisted methods for evaluating retinal vasculature).
Focus on the Role of Inflammation as a Bridge between Ferroptosis and Atrial Fibrillation: A Narrative Review and Novel Perspective
Authors: Jin Chenyang , Zhong Zikan , Gao Longzhe , Wu Xiaoyu , Zhou Changzuan , Zhou Genqing , Liu Shaowen
Published: April 2024

In this comprehensive review, we examine the intricate interplay between inflammation, ferroptosis, and atrial fibrillation (AF), highlighting their significant roles in AF pathophysiology and pathogenesis. Augmented inflammatory responses are pivotal to AF, potentially leading to atrial remodeling and reentry phenomena by impacting calcium channels and atrial tissue fibrosis. A strong correlation exists between inflammatory cytokines and AF, underscoring the importance of inflammatory signaling pathways, such as NOD-like receptor thermal protien domain associated protein 3 (NLRP3) inflammasome, Nuclear Factor kappa B (NF-κB) signaling, and Tumor necrosis factor-α (TNF-α) signaling in AF development. Ferroptosis, a non-apoptotic regulated mode of cell death, has been widely studied in relation to cardiovascular diseases including heart failure, myocardial infarction, cardiomyopathy, and reperfusion injury. The interaction between ferroptosis and inflammation is complex and mutually influential. While significant progress has been made in understanding the inflammation-AF relationship, the role of inflammation as a conduit linking ferroptosis and AF remains underexplored. The specific pathogenesis and key molecules of atrial fibrosis caused by ferroptosis are still not fully understood. Here we review the role of inflammatory signaling in ferroptosis and AF. We elucidated the association between ferroptosis and AF, aiming to unveil mechanisms for targeted inhibition of atrial cell fibrosis and to propose novel therapeutic strategies for AF. This exploration is vital for advancing our knowledge and developing more effective interventions for AF, a condition deeply intertwined with inflammatory processes and ferroptotic pathways.
High Serum Galectin-3 Level as a Potential Biomarker of Peripheral Artery Disease in Patients Undergoing Hemodialysis
Authors: Chiu Liang-Te , Hsu Bang-Gee , Lai Yu-Hsien , Wang Chih-Hsien , Tsai Jen-Pi
Published: April 2024

Background: Galectin-3 is implicated in the pathogenesis of inflammation and atherosclerosis. Peripheral arterial disease (PAD), characterized by a reduced ankle-brachial index (ABI), is a prognostic marker for mortality in patients on hemodialysis. We investigated the relationship between serum galectin-3 levels and PAD in patients undergoing regular hemodialysis. Methods: We carried out a cross-sectional study at a medical center, involving 92 participants. Serum galectin-3 levels were assessed by a commercially available enzyme-linked immunosorbent assay. ABI measurement was done with an automatic device based on oscillometry. Participants were categorized into two groups, normal and low ABI, based on a 0.9 cut-off point. Results: Eighteen patients (19.6%) exhibited a low ABI. In individuals with low ABIs, we observed a greater prevalence of diabetes mellitus, elevated serum C-reactive protein (CRP) levels, increased galectin-3 levels, and lower serum creatinine levels. Furthermore, serum galectin-3 levels (odds ratio [OR]: 1.056, 95% confidence interval [CI]: 1.003–1.112, p = 0.037) and CRP (per 0.1 mg/dL increment, OR: 1.195, 95% CI: 1.032–1.383, p = 0.017) were identified as independent predictors of PAD. Serum galectin-3 and log-transformed CRP levels were also independently and significantly negatively correlated with the left and right ABI values. Conclusions: Serum galectin-3 levels correlate with PAD in patients undergoing maintenance hemodialysis.
Dynamics of hyperchromic and MyoD-positive nuclei of regenerating skeletal muscles during infrared photomodulation
Authors:   South Ural State Medical University, Chelyabinsk, Takhaviev R.V. , Bryukhin G.V. ,   South Ural State Medical University, Chelyabinsk, Golovneva E.S. ,   South Ural State Medical University, Chelyabinsk
Published: April 2024

Introduction. Currently, there are no techniques that allow to fully restore skeletal muscle tissue after injury. Infrared laser exposure is a universal physiotherapeutic method used to activate proliferation, increase enzyme activity, and reduce inflammation and edema. At the same time, the influence of the exposure time of infrared laser irradiation on the activation of myosatellite cells has been poorly studied. The paper aimed to analyze the effect of the duration of infrared laser irradiation on the state of cambial reserve cells in regenerating skeletal muscle tissue. Materials and methods. In the experiment (128 male Wistar rats), 4 groups were formed: 0 – intact group; I (dynamic control) – incised wound m. gastrocnemius; II – laser irradiation of the wound with a 60- second exposure; and III – laser irradiation of the wound with a 180-second exposure.The laser was used in a continuous mode, the power being 1.0 W. We performed a morphological study of the area of hyperchromatic muscle nuclei and the density of MyoD+ nuclei at different periods of the experiment. Results. In group III, the area of hyperchromatic nuclei decreased on day 1, and on day 7, it was 30% more than in group I. The density of the arrangement of MyoD+ nuclei in groups II and III increased compared to that in group I for a period of 3 days, regardless of the exposure time. However, on day 7, the number of nuclei was greater in group II. Conclusion. After the use of an infrared laser with a 60-second exposure, the density of MyoD+ nuclei increases, whereas the effect of a 180-second laser exposure has a more dramatic effect on the increase in the area of hyperchromic nuclei of muscle tissue.