bluuebunny/crossref_metadata_2025 huggingface dataset:
Delay of Gratification in Predicting Job Performance in New Employees: A Time-Varying Process and the Moderating Role of Perceived Informational Justice
Authors: Liu Xiaoyan , Yu Kun
Published: April 2017

Our study profiles a varying process of the relationship between delay of gratification (DG) and job performance over time and examines the moderating role of perceived organisational justice in the DG-job performance relationship. Employees’ ability to delay gratification was measured during their job interviews (Time 1). When they had worked for 3 months (Time 2), their job performance was rated by their supervisors. When they had worked for 5 months (Time 3), their perception of perceived informational justice was measured. Their job performance was rated again by their supervisors at 6 months (Time 4). The results showed that DG could directly predict new employees’ short-term (3-month) job performance but not their longer-term (6-month) job performance. Moreover, perceived informational justice moderated the relationship between DG and 6-month job performance.
THE TAMING OF JOGEE?
Authors: Stark Findlay
Published: April 2017

WHEN the ambit of the criminal law is narrowed judicially, what impact should this have on convictions previously secured under the disavowed, broader rules? This question was considered by the Court of Appeal in Johnson and Others [2016] EWCA Crim 1613, [2017] 1 Cr. App. R. 12.
SENECAN SIGNIFICATION.TROADES1055
Authors: Allendorf T.S.
Published: April 2017

The fourth choral ode in Seneca's tragedyTroadesends thus (1050–5):tum puer matri genetrixque natoTroia qua iaceat regione monstransdicet et longe digito notabit:‘Ilium est illic, ubi fumus alteserpit in caelum nebulaeque turpes.’Troes hoc signo patriam uidebunt.This ending provides a powerful conclusion to the Chorus’ Epicurean-inspired philosophizing in the ode. The image of the Trojan women ‘seeing’ (uidebunt) the ‘smoke and squalid clouds creep[ing] high into the heavens’ (1053–4) recalls the Lucretian description of the soul, atomic in nature, leaving the dead body: compare especiallyet nebula ac fumus quoniam discedit in auras,|crede animam quoque diffundi …(Lucr. 3.436–7) andergo dissolui quoque conuenit omnem animai|naturam, ceu fumus, in altas aeris auras(Lucr. 3.455–6). The image and the Lucretian resonance also create an intratextual link with the second ode ofTroades(371–408). In that ode, the Chorus set out to develop a philosophical position about the question of death and the possibility of an afterlife. Their philosophizing is aided by Lucretian language and imagery, and the clear verbal echoes of Lucretius include the soul escaping into air like vapour: ‘the spirit, with fleeing breath, has mingled with the clouds and passed away into air’ (…profugo spiritus halitu|immixtus nebulis cessit in aera, 379–80), which recalls the Lucretian lines above. At the end of the fourth ode, the Lucretian intertext of the smoke image is linked to another startling element that may point to (Epicurean) philosophizing: Seneca's use ofsignum(1055).
EMPEDOCLES’ ON NATURE FRR. B 8–9 IN THE CONTEXT OF PLUTARCH'S AGAINST COLOTES
Authors: Janko Richard
Published: April 2017

The Epicurean Colotes, in a work entitled Περὶ τοῦ ὅτι κατὰ τὰ τῶν ἄλλων φιλοσόφων οὐδὲ ζῆν ἔστιν, cited two fragments of Empedocles in order to prove that the poet denied that existence exists (frr. B 8–9 DK = 12–13 Wright). Both are prominent in controversies about Empedocles’ physics and his usage of the term φύσις, but fr. 9 is very corrupt. To have any hope of restoring it, we will need to examine carefully Plutarch's explication de texte in his Adversus Colotem (10–12, 1111f–1113e). Although there have been two detailed treatments of this passage, neither has resolved the difficulties.
THE TRIUMPH OF THE STATE: SINGAPORE'S DOCKWORKERS AND THE LIMITS OF GLOBAL HISTORY, c. 1920–1965
Authors: CURLESS GARETH
Published: April 2017

Labour history has been revitalized by the global turn. It has encouraged historians to look beyond national frameworks to explore issues relating to mobility and inter-territorial connection. This article, while accepting the benefits of a global approach, argues that historians should not lose sight of the factors that constrain mobility or lead to the collapse of cross-border exchanges. Singapore's dockworkers were at the forefront of the island's anti-colonial campaigns of the 1940s and 1950s. Inspired by anti-colonial movements elsewhere in the world, dockworkers drew on international discourses relating to self-determination to place their local struggles in a global context. This activism, however, coincided with the emergence of countervailing forces, including the universalization of the nation-state and the rise of state-led developmentalism. In this context, dockworkers’ internationalism came to be regarded as a threat to state sovereignty and development. As a result, once Singapore achieved independence the ruling People's Action Party encouraged dockworkers to abandon their globalized outlook in the name of modernization and nation building. Global history, then, should be as much about the rise of the national as the transnational, and the loss of connection as the forging of inter-territorial networks.
Relationship between interatrial communication, ductus arteriosus, and pulmonary flow patterns in fetuses with transposition of the great arteries: prediction of neonatal desaturation
Authors: Vaujois Laurence , Boucoiran Isabelle , Preuss Christophe , Brassard Myriam , Houde Christine , Fouron Jean C. , Raboisson Marie-Josée
Published: April 2017

Background

The relationship between interatrial communication, ductus arteriosus, and pulmonary flow in transposition of the great arteries and intact ventricular septum may help predict postnatal desaturation.

Methods

Echocardiographic data of 45 fetuses with transposition of the great arteries and intact ventricular septum and 50 age-matched controls were retrospectively reviewed. Interatrial communication, left and right ventricular output, flow in the ductus arteriosus, as well as effective pulmonary flow were measured. Patients were divided into two groups on the basis of postnatal saturations: group 1 had saturations ⩽50% and group 2 >50%.

Results

Of 45 fetuses, 13 (26.7%) were classified into group 1. Compared with fetuses in group 2, they had a smaller interatrial communication (2.9 versus 4.0 mm, p=0.004) and more retrograde diastolic flow in the ductus arteriosus (92 versus 23%, p=0.002). Both groups showed a significant decrease in ductal flow compared with controls. Patients in group 2 had a higher effective pulmonary flow compared with controls. There was a mild correlation between left ventricular output and size of the interatrial communication (Spearman’s rank correlation 0.44).

Conclusion

A retrograde diastolic flow is present in most of the fetuses with postnatal desaturation. Fetuses with transposition of the great arteries have a lower flow through the ductus arteriosus compared with controls. Fetuses without restrictive foramen ovale have higher effective pulmonary flow. Peripheral pulmonary vasodilatation due to higher oxygen saturation in pulmonary arteries in the case of transposition of the great arteries could be one possible cause.
Developmental screening in children with CHD: Ages and Stages Questionnaires
Authors: Noeder Maia M. , Logan Beth A. , Struemph Kari L. , Condon Nancy , Mueller Isabel , Sands Barbara , Davies Ryan R. , Sood Erica
Published: April 2017

Objective

Standardised developmental screening tools are important for the evaluation and management of developmental disorders in children with CHD; however, psychometric properties and clinical utility of screening tools, such as the Ages & Stages Questionnaires, Third Edition (ASQ-3), have not been examined in the CHD population. We hypothesised that the ASQ-3 would be clinically useful for this population.

Study design

ASQ-3 developmental classifications for 163 children with CHD at 6, 12, 24, and/or 36 months of age were compared with those obtained from concurrent developmental testing with the Bayley Scales of Infant and Toddler Development, Third Edition.

Results

When ASQ-3 screening failure was defined as ⩾1 SD below the normative mean, specificity (⩾81.9%) and negative predictive value (⩾81.0%) were high across ASQ-3 areas. Sensitivity was high for gross motor skills (79.6%), increased with age for communication (35.7–100%), and generally decreased with age for problem solving (73.1–50.0%). When ASQ-3 screening failure was defined as ⩾2 SD below the normative mean, specificity (⩾93.6%) and positive predictive value (⩾74.5%) were generally high across ASQ-3 areas, but sensitivity was low (31.1%) to fair (62.8%). The ASQ-3 showed improved accuracy in predicting delays over clinical risk factors alone.

Conclusions

The ASQ-3 appears to be a clinically useful tool for screening development in children with CHD, although its utility varied on the basis of developmental area and time point. Clinicians are encouraged to refer children scoring ⩾1 SD below the normative mean on any ASQ-3 area for formal developmental evaluation.
The Ancient and Modern Power of Islamic Sermons in Contemporary Pakistan
Authors: ROBINSON SAM
Published: April 2017

Despite the Pakistan-Afghan border's importance as the epicentre of regional insurgency, the mechanisms by which Friday sermons may be stimulating Islamic ideology have been understudied. From an analysis of 250 hours of sermons in the local Pashto language, interviews withmullahsand survey work, Robinson argues that sermons are a powerful means by which sectarian tensions and traditional ideologies are propagated. Their influence is derived from an irresistible synergy of both ancient and modern. They gain traction from using a highly credible ancient sermon form - rich in poetics and sparkling oratory - which is multiplied by the use of modern media. The religious ideology they traffic continues to grip the imagination of Pashtuns in ways which shape their society and provides a bulwark against secular intruders.
ADAM FERGUSON ON PARTISANSHIP, PARTY CONFLICT, AND POPULAR PARTICIPATION
Authors: SKJÖNSBERG MAX
Published: April 2017

Adam Ferguson has usually been portrayed as an advocate of conflict, political parties, and factional strife. This article demonstrates that this is a rather unbalanced reading. A careful investigation of Ferguson's works and correspondence in context reveals a man deeply troubled by both turbulence and party politics. He consistently expressed fears of what he saw as the tumultuous populace, and the willingness of party leaders to rise on the shoulders of the mob. This could ultimately lead to military despotism, something he dreaded. While Ferguson's theory of antagonistic sociability was original, this article shows that we should not take for granted that it implied an approval of party conflict in a broad sense. Indeed, he was highly critical of opposition parties seeking to replace the government. He did tolerate a regulated form of contest between different orders in the state under a mixed constitution, but it is here argued that he is much better understood as a Christian Stoic promoting stability and order than a supporter of party struggle.
FORTY ACRES AND A CARABAO: T. THOMAS FORTUNE, NEWSPAPERS, AND THE PACIFIC'S UNSTABLE COLOR LINES, 1902–03
Authors: Shott Brian
Published: April 2017

In late 1902, exhaustion, financial distress, and the desire for a political appointment—combined with aspirations to serve as a broker for the export of African American labor abroad—led famed African American journalist T. Thomas Fortune to secure a temporary appointment with the Roosevelt administration to investigate trade and labor in Hawaii and the Philippines. In Hawaii, Fortune was fêted by the planter class, and allied himself publicly with the educational and political philosophies of Booker T. Washington. His hopes for black emigration and land ownership, however, were vigorously opposed by most newspapers connected to the oligarchy. Hawaii's robust in-language indigenous and ethnic newspapers, meanwhile, voiced their own position on black labor. In Manila, a fiercely entrepreneurial and militaristic American press attacked Fortune. Recent scholarship ties Washington's Tuskegee Institute to a kind of “Jim Crow colonialism” abroad. An in-depth look at Fortune's journey both supports and troubles such a view. Both men hoped U.S. “expansion,” and African American participation in it, might expose not only the power of race, but also its instability and vulnerability; Fortune, in particular, saw newspapers as vital to this task.
How to diagnose democratic deficits in global politics: the use of the ‘all-affected principle’
Authors: Koenig-Archibugi Mathias
Published: April 2017

Is there a ‘democratic deficit’ in global politics? If so, which changes in institutions and practices can mitigate it? Empirically oriented scholars who ask such questions often use as a yardstick the normative principle that people significantly affected by a decision should be able to take part in reaching that decision. This ‘all-affected principle’ is also endorsed by prominent political theorists. However, its most logically consistent interpretation seems so demanding that it casts doubt on the principle’s usefulness to guide the assessment of real-world situations, since it appears to require that virtually everyone in the world should have a say on any proposal or any proposal for proposals. The argument presented here intends to rescue the principle as a tool for empirical assessments of real-world situations by stressing its role in comparative judgments and especially by showing that its implications are not too expansive and/or indeterminate, once we take into account that certain types of prior decisions significantly restrict the agenda of other decisions in a systematic way. The theoretical guidance for empirical research offered in the first part of the article is then illustrated with an application to global child labor policies.
Mental health service use, depression, panic disorder and life events among Swedish young adults in 2000 and 2010: a repeated cross-sectional population study in Stockholm County, Sweden
Authors: Lundin A. , Forsell Y. , Dalman C.
Published: April 2017

Aims.

The use of specialised psychiatric services for depression and anxiety has increased steadily among young people in Sweden during recent years. It is not known to what extent this service use is due to an increase in psychiatric morbidity, or whether other adversities explain these trends. The aim of this study is to examine if there is increased use of psychiatric services among young adults in Sweden between 2000 and 2010, and if so, to what extent this increase is associated with differences in depression, anxiety and negative life events.

Methods.

This is a repeated cross-sectional study of 20–30-year old men and women in Stockholm County in 2000 and 2010 (n = 2590 and n = 1120). Log-binomial regression analyses were conducted to compare the prevalence of service use, depression and panic disorder between the two cohorts. Self-reported life events were entered individually and as a summary index, and entered as potential mediators. Different effects of life events on service use were examined through interaction analysis. We report prevalence proportion ratios (PPR) with 95% confidence intervals.

Results.

Specialised psychiatric service use, but also depression and panic disorder was more common in the younger cohort (current service use 2.4 and 5.0%). The younger cohort did not report more life events overall or among those with depression or anxiety. Neither depression, panic disorder nor life events could explain the increased use of psychiatric services in the younger cohort (Fully adjusted model PPR = 1.70, 1.20–2.40 95% CI). There was no significant interaction between cohort and life events in predicting psychiatric service use.

Conclusion.

This study provides initial support for an increase in service use among young adults compared with 10 years earlier. The increased service use cannot be explained with increasing worse life situations.
Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
Authors: Nobili Annalisa , Latagliata Emanuele Claudio , Viscomi Maria Teresa , Cavallucci Virve , Cutuli Debora , Giacovazzo Giacomo , Krashia Paraskevi , Rizzo Francesca Romana , Marino Ramona , Federici Mauro , De Bartolo Paola , Aversa Daniela , Dell’Acqua Maria Concetta , Cordella Alberto , Sancandi Marco , Keller Flavio , Petrosini Laura , Puglisi-Allegra Stefano , Mercuri Nicola Biagio , Coccurello Roberto , Berretta Nicola , D’Amelio Marcello
Published: April 2017

Alterations of the dopaminergic (DAergic) system are frequently reported in Alzheimer’s disease (AD) patients and are commonly linked to cognitive and non-cognitive symptoms. However, the cause of DAergic system dysfunction in AD remains to be elucidated. We investigated alterations of the midbrain DAergic system in the Tg2576 mouse model of AD, overexpressing a mutated human amyloid precursor protein (APPswe). Here, we found an age-dependent DAergic neuron loss in the ventral tegmental area (VTA) at pre-plaque stages, although substantia nigra pars compacta (SNpc) DAergic neurons were intact. The selective VTA DAergic neuron degeneration results in lower DA outflow in the hippocampus and nucleus accumbens (NAc) shell. The progression of DAergic cell death correlates with impairments in CA1 synaptic plasticity, memory performance and food reward processing. We conclude that in this mouse model of AD, degeneration of VTA DAergic neurons at pre-plaque stages contributes to memory deficits and dysfunction of reward processing.
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
Authors: Betancur Paola A. , Abraham Brian J. , Yiu Ying Y. , Willingham Stephen B. , Khameneh Farnaz , Zarnegar Mark , Kuo Angera H. , McKenna Kelly , Kojima Yoko , Leeper Nicholas J. , Ho Po , Gip Phung , Swigut Tomek , Sherwood Richard I. , Clarke Michael F. , Somlo George , Young Richard A. , Weissman Irving L.
Published: April 2017

CD47 is a cell surface molecule that inhibits phagocytosis of cells that express it by binding to its receptor, SIRPα, on macrophages and other immune cells. CD47 is expressed at different levels by neoplastic and normal cells. Here, to reveal mechanisms by which different neoplastic cells generate this dominant ‘don’t eat me’ signal, we analyse the CD47 regulatory genomic landscape. We identify two distinct super-enhancers (SEs) associated with CD47 in certain cancer cell types. We show that a set of active constituent enhancers, located within the two CD47 SEs, regulate CD47 expression in different cancer cell types and that disruption of CD47 SEs reduces CD47 gene expression. Finally we report that the TNF-NFKB1 signalling pathway directly regulates CD47 by interacting with a constituent enhancer located within a CD47-associated SE specific to breast cancer. These results suggest that cancers can evolve SE to drive CD47 overexpression to escape immune surveillance.
Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
Authors: Kahr Walter H. A. , Pluthero Fred G. , Elkadri Abdul , Warner Neil , Drobac Marko , Chen Chang Hua , Lo Richard W. , Li Ling , Li Ren , Li Qi , Thoeni Cornelia , Pan Jie , Leung Gabriella , Lara-Corrales Irene , Murchie Ryan , Cutz Ernest , Laxer Ronald M. , Upton Julia , Roifman Chaim M. , Yeung Rae S. M. , Brumell John H , Muise Aleixo M
Published: April 2017

Human actin-related protein 2/3 complex (Arp2/3), required for actin filament branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in blood cells. Here we show in a child with microthrombocytopenia, eosinophilia and inflammatory disease, a homozygous frameshift mutation in ARPC1B (p.Val91Trpfs*30). Platelet lysates reveal no ARPC1B protein and greatly reduced Arp2/3 complex. Missense ARPC1B mutations are identified in an unrelated patient with similar symptoms and ARPC1B deficiency. ARPC1B-deficient platelets are microthrombocytes similar to those seen in Wiskott–Aldrich syndrome that show aberrant spreading consistent with loss of Arp2/3 function. Knockout of ARPC1B in megakaryocytic cells results in decreased proplatelet formation, and as observed in platelets from patients, increased ARPC1A expression. Thus loss of ARPC1B produces a unique set of platelet abnormalities, and is associated with haematopoietic/immune symptoms affecting cell lineages where this isoform predominates. In agreement with recent experimental studies, our findings suggest that ARPC1 isoforms are not functionally interchangeable.
Optimal free descriptions of many-body theories
Authors: Turner Christopher J. , Meichanetzidis Konstantinos , Papić Zlatko , Pachos Jiannis K.
Published: April 2017

Interacting bosons or fermions give rise to some of the most fascinating phases of matter, including high-temperature superconductivity, the fractional quantum Hall effect, quantum spin liquids and Mott insulators. Although these systems are promising for technological applications, they also present conceptual challenges, as they require approaches beyond mean-field and perturbation theory. Here we develop a general framework for identifying the free theory that is closest to a given interacting model in terms of their ground-state correlations. Moreover, we quantify the distance between them using the entanglement spectrum. When this interaction distance is small, the optimal free theory provides an effective description of the low-energy physics of the interacting model. Our construction of the optimal free model is non-perturbative in nature; thus, it offers a theoretical framework for investigating strongly correlated systems.
The pleiotropic regulation of cyclin D1 by newly identified sesaminol-binding protein ANT2
Authors: Watanabe M , Iizumi Y , Sukeno M , Iizuka-Ohashi M , Sowa Y , Sakai T
Published: April 2017

The expression of cyclin D1 is upregulated in various cancer cells by diverse mechanisms, such as increases in mRNA levels, the promotion of the translation by mammalian target of rapamycin complex 1 (mTORC1) signaling and the protein stabilization. We here show that sesaminol, a sesame lignan, reduces the expression of cyclin D1 with decreasing mRNA expression levels, inhibiting mTORC1 signaling and promoting proteasomal degradation. We subsequently generated sesaminol-immobilized FG beads to newly identify sesaminol-binding proteins. As a consequence, we found that adenine nucleotide translocase 2 (ANT2), the inner mitochondrial membrane protein, directly bound to sesaminol. Consistent with the effects of sesaminol, the depletion of ANT2 caused a reduction in cyclin D1 with decreases in its mRNA levels, mTORC1 inhibition and the proteasomal degradation of its protein, suggesting that sesaminol negatively regulates the function of ANT2. Furthermore, we screened other ANT2-binding compounds and found that the proliferator-activated receptor-γ agonist troglitazone also reduced cyclin D1 expression in a multifaceted manner, analogous to that of the sesaminol treatment and ANT2 depletion. Therefore, the chemical biology approach using magnetic FG beads employed in the present study revealed that sesaminol bound to ANT2, which may pleiotropically upregulate cyclin D1 expression at the mRNA level and protein level with mTORC1 activation and protein stabilization. These results suggest the potential of ANT2 as a target against cyclin D1-overexpressing cancers.
Use of Radiation Therapy in Metastatic Nasopharyngeal Cancer Improves Survival: A SEER Analysis
Authors: Hu Jiyi , Kong Lin , Gao Jing , Hu Weixu , Guan Xiyin , Lu Jiade J.
Published: April 2017

Limited data indicated radiotherapy might provide survival benefits to patients with distantly metastatic nasopharyngeal carcinoma (mNPC). We used the Surveillance Epidemiology and End Results database to examine the role of radiotherapy in the treatment of mNPC. Patients with mNPC at presentation diagnosed between 1988 and 2012 were enrolled. The outcome of interest included overall survival (OS) and cancer-specific survival (CSS). A total of 679 patients with a median follow-up of 13 months were identified. Four hundred forty-eight patients received radiotherapy and 231 did not. Radiotherapy was associated with significantly improved OS and CSS in both univariate and multivariate analyses. Weighted Cox regression by inverse probability of treatment weighting (IPTW) using propensity score (PS) showed a 50% reduced risk of mortality in patients who received radiotherapy with regards to both OS (HR: 0.50, 95% CI: 0.41–0.60, p < 0.001) and CSS (HR: 0.50, 95% CI: 0.40–0.61, p < 0.001), respectively. Further, patients with a younger age (<65 year-old), diagnosed after 2003, with non-keratinizing carcinoma or undifferentiated carcinoma, and who received surgery had better outcomes for both OS and CSS. Local radiotherapy was associated with improved survival in patients with mNPC. Our findings warrant prospective investigation in clinical trials.
Giant field enhancement in high-index dielectric subwavelength particles
Authors: Kapitanova Polina , Ternovski Vladimir , Miroshnichenko Andrey , Pavlov Nikita , Belov Pavel , Kivshar Yuri , Tribelsky Michael
Published: April 2017

Besides purely academic interest, giant field enhancement within subwavelength particles at light scattering of a plane electromagnetic wave is important for numerous applications ranging from telecommunications to medicine and biology. In this paper, we experimentally demonstrate the enhancement of the intensity of the magnetic field in a high-index dielectric cylinder at the proximity of the dipolar Mie resonances by more than two orders of magnitude for both the TE and TM polarizations of the incident wave. We present a complete theoretical explanation of the effect and show that the phenomenon is very general – it should be observed for any high-index particles. The results explain the huge enhancement of nonlinear effects observed recently in optics, suggesting a new landscape for all-dielectric nonlinear nanoscale photonics.
Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
Authors: Toden Shusuke , Theiss Arianne L. , Wang Xuan , Goel Ajay
Published: April 2017

Turmeric has been used as a medicinal herb for thousands of years for treatment of various disorders. Although curcumin is the most studied active constituents of turmeric, accumulating evidence suggests that other components of turmeric have additional anti-inflammatory and anti-tumorigenic properties. Herein, we investigated anti-inflammatory efficacy and associated gene expression alterations of a specific, curcumin preparation containing essential turmeric oils (ETO-curcumin) in comparison to standard curcumin at three specific doses (0, 5, 25 or 50 mg/kg), in an animal model of dextran sodium sulfate (DSS)-induced colitis. The present study showed that both ETO and standard curcumin treatments provided protection against DSS-induced inflammation. However, ETO-curcumin improved disease ﻿activity index (DAI) dose-dependently, while the anti-inflammatory efficacy of standard curcumin remained constant, suggesting that ETO-curcumin may provide superior anti-inflammatory efficacy compared to standard curcumin. Gene expression analysis revealed that anti-inflammatory cytokines including IL-10 and IL-11 as well as FOXP3 were upregulated in the colon by ETO-curcumin. Collectively, these findings suggest that the combined treatment of curcumin and essential turmeric oils provides superior protection from DSS-induced colitis than curcumin alone, highlighting the anti-inflammatory potential of turmeric.
Estrogen-Related Factors in the Frontal Lobe of Alzheimer’s Disease Patients and Importance of Body Mass Index
Authors: Honma Naoko , Saji Shigehira , Mikami Tetuo , Yoshimura Noriko , Mori Seijiro , Saito Yuko , Murayama Shigeo , Harada Nobuhiro
Published: April 2017

Estrogens play a physiologically important role in the brain, but controversies exist regarding the association between Alzheimer’s disease (AD) and estrogens. Estrogen-related factors were comprehensively examined in frontal lobe tissues from autopsied AD patients, and compared with controls. Concentrations of estrogens, expression of estrogen receptors (ERs), and estrogen-metabolizing enzymes (EMEs) which are important for determining the peripheral estrogen concentrations, were examined using liquid chromatography tandem mass spectrometry, immunohistochemistry, and quantitative real-time PCR, respectively. Body mass index (BMI), known to correlate with the serum estrogen concentrations, was also taken into consideration. There were no significant differences in estrogen concentrations or each EME level between the two groups in both the cortex and white matter, whereas glial nuclear ER-β expression was significantly lower in white matter from the AD group than the control group (Allred score, 3.2 ± 0.3 and 6.5 ± 0.3, respectively. P < 0.0001). Estrogen concentrations were found to closely correlate with BMI, particularly in controls. ER-β loss in the white matter from the AD group suggests the necessity of studying the effects of estrogens on glias as well as neurons in the etiology of AD. The correlation between BMI and estrogen concentrations in the frontal lobe suggests the importance of non-brain sources of estrogens.
Recombinant Slit2 Reduces Surgical Brain Injury Induced Blood Brain Barrier Disruption via Robo4 Dependent Rac1 Activation in a Rodent Model
Authors: Sherchan Prativa , Huang Lei , Akyol Onat , Reis Cesar , Tang Jiping , Zhang John H.
Published: April 2017

Brain tissue surrounding surgical resection site can be injured inadvertently due to procedures such as incision, retractor stretch, and electrocauterization when performing neurosurgical procedures, which is termed as surgical brain injury (SBI). Blood brain barrier (BBB) disruption due to SBI can exacerbate brain edema in the post-operative period. Previous studies showed that Slit2 exhibited vascular anti-permeability effects outside the brain. However, BBB protective effects of Slit2 following SBI has not been evaluated. The objective of this study was to evaluate whether recombinant Slit2 via its receptor roundabout4 (Robo4) and the adaptor protein, Paxillin were involved in reducing BBB permeability in SBI rat model. Our results showed that endogenous Slit2 increased in the surrounding peri-resection brain tissue post-SBI, Robo4 remained unchanged and Paxillin showed a decreasing trend. Recombinant Slit2 administered 1 h before injury increased BBB junction proteins, reduced BBB permeability, and decreased neurodeficits 24 h post-SBI. Furthermore, recombinant Slit2 administration increased Rac1 activity which was reversed by Robo4 and Paxillin siRNA. Our findings suggest that recombinant Slit2 reduced SBI-induced BBB permeability, possibly by stabilizing BBB tight junction via Robo4 mediated Rac1 activation. Slit2 may be beneficial for BBB protection during elective neurosurgeries.
Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium
Authors: Feng Yun , Wang Yanru , Liu Hongliang , Liu Zhensheng , Mills Coleman , Han Younghun , Hung Rayjean J. , Brhane Yonathan , McLaughlin John , Brennan Paul , Bickeboeller Heike , Rosenberger Albert , Houlston Richard S. , Caporaso Neil E. , Teresa Landi Maria , Brueske Irene , Risch Angela , Ye Yuanqing , Wu Xifeng , Christiani David C. , Amos Christopher I. , Wei Qingyi
Published: April 2017

The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events mediated by TCPTP. Mutations and genetic variants of some genes in the TCPTP pathway are associated with lung cancer risk and survival. In the present study, we first investigated associations of 5,162 single nucleotide polymorphisms (SNPs) in 43 genes of this TCPTP pathway with lung cancer risk by using summary data of six published genome-wide association studies (GWAS) of 12,160 cases and 16,838 controls. We identified 11 independent SNPs in eight genes after correction for multiple comparisons by a false discovery rate <0.20. Then, we performedin silicofunctional analyses for these 11 SNPs by eQTL analysis, two of which,PTPN2SNPs rs2847297 and rs2847282, were chosen as tagSNPs. We further included two additional GWAS datasets of Harvard University (984 cases and 970 controls) and deCODE (1,319 cases and 26,380 controls), and the overall effects of these two SNPs among all eight GWAS studies remained significant (OR = 0.95, 95% CI = 0.92–0.98, andP = 0.004 for rs2847297; OR = 0.95, 95% CI = 0.92–0.99, andP = 0.009 for rs2847282). In conclusion, thePTPN2rs2847297 and rs2847282 may be potential susceptible loci for lung cancer risk.
Flexible metal-semiconductor-metal device prototype on wafer-scale thick boron nitride layers grown by MOVPE
Authors: Li Xin , Jordan Matthew B. , Ayari Taha , Sundaram Suresh , El Gmili Youssef , Alam Saiful , Alam Muhbub , Patriarche Gilles , Voss Paul L. , Paul Salvestrini Jean , Ougazzaden Abdallah
Published: April 2017

Practical boron nitride (BN) detector applications will require uniform materials over large surface area and thick BN layers. To report important progress toward these technological requirements, 1~2.5 µm-thick BN layers were grown on 2-inch sapphire substrates by metal-organic vapor phase epitaxy (MOVPE). The structural and optical properties were carefully characterized and discussed. The thick layers exhibited strong band-edge absorption near 215 nm. A highly oriented two-dimensional h-BN structure was formed at the film/sapphire interface, which permitted an effective exfoliation of the thick BN film onto other adhesive supports. And this structure resulted in a metal-semiconductor-metal (MSM) device prototype fabricated on BN membrane delaminating from the substrate. MSM photodiode prototype showed low dark current of 2 nA under 100 V, and 100 ± 20% photoconductivity yield for deep UV light illumination. These wafer-scale MOVPE-grown thick BN layers present great potential for the development of deep UV photodetection applications, and even for flexible (opto-) electronics in the future.
Photoacoustic imaging reveals hidden underdrawings in paintings
Authors: Tserevelakis George J. , Vrouvaki Ilianna , Siozos Panagiotis , Melessanaki Krystallia , Hatzigiannakis Kostas , Fotakis Costas , Zacharakis Giannis
Published: April 2017

A novel, non-invasive, imaging methodology, based on the photoacoustic effect, is introduced in the context of artwork diagnostics with emphasis on the uncovering of hidden features such as underdrawings or original sketch lines in paintings. Photoacoustic microscopy, a rapidly growing imaging method widely employed in biomedical research, exploits the ultrasonic acoustic waves, generated by light from a pulsed or intensity modulated source interacting with a medium, to map the spatial distribution of absorbing components. Having over three orders of magnitude higher transmission through strongly scattering media, compared to light in the visible and near infrared, the photoacoustic signal offers substantially improved detection sensitivity and achieves excellent optical absorption contrast at high spatial resolution. Photoacoustic images, collected from miniature oil paintings on canvas, illuminated with a nanosecond pulsed Nd:YAG laser at 1064 nm on their reverse side, reveal clearly the presence of pencil sketch lines coated over by several paint layers, exceeding 0.5 mm in thickness. By adjusting the detection bandwidth of the optically induced ultrasonic waves, photoacoustic imaging can be used for looking into a broad variety of artefacts having diverse optical properties and geometrical profiles, such as manuscripts, glass objects, plastic modern art or even stone sculpture.
Root-mediated sex recognition in a dioecious tree
Authors: Dong Tingfa , Li Junyu , Liao Yongmei , Chen Bin J. W. , Xu Xiao
Published: April 2017

Recent studies have demonstrated that plants can determine the identity of neighbouring roots (e.g., self and non-self, kin and non-kin), but whether they can discriminate by sex remains an open question. Here, we predict that dioecious plants can modulate their root performance in response to local root conditions related to sex. Female and malePopulus cathayanacuttings were planted in a greenhouse in root-owner (one individual without a root neighbour) or root-sharer pairs (two individuals with roots neighbouring each other) with equal amounts of nutrients and space per plant in three combinations (females–females, males–males or females–males); root morphology, biomass and allocation were investigated.P.cathayanaroot-sharers altered their root growth in same-sex but not in different-sex combinations. Females enhanced root growth and allocation but decreased root proliferation (greater diameter with reduced branching and specific root length) in the presence of a female root neighbour, while males reduced root growth but increased root morphological proliferation in contact with another male. Therefore, the effect of a neighbour of the same sex differed from that of a neighbour of the opposite sex, which suggests that these plants can recognize the sexual identity of their neighbours.
Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
Authors: Wang Zhiwei , Ma Yuhai , Wei Jie , Chen Xiao , Cao Liehu , Weng Weizong , Li Quan , Guo Han , Su Jiacan
Published: April 2017

Magnesium phosphate (MP) was fabricated using a chemical precipitation method, and the biological performances of MP sintered at different temperatures as a biomedical material was investigated. The results indicated that the densification and crystallinity of MP increased as the sintering temperature increased. As the sintering temperature increased, the degradability of MP in PBS decreased, and the mineralization ability in SBF significantly increased. In addition, the MP sintered at 800 °C (MP8) possessed the lowest degradability and highest mineralization ability. Moreover, the positive response of MG63 cells to MP significantly increased as the sintering temperature increased, and MP8 significantly promoted the cell spreading, proliferation, differentiation and expressions of osteogenic differentiation-related genes. Faster degradation of MP0 resulted in higher pH environments and ion concentrations, which led to negative responses to osteoblasts. However, the appropriate degradation of MP8 resulted in suitable pH environments and ion concentrations, which led to positive responses to osteoblasts. This study demonstrated that the sintering temperature substantially affected the surface morphology/microstructure, degradability and mineralization, and osteoblasts response to magnesium phosphate.
Water-carbon dioxide solid phase equilibria at pressures above 4 GPa
Authors: Abramson E. H. , Bollengier O. , Brown J. M.
Published: April 2017

A solid phase in the mixed water-carbon dioxide system, previously identified as carbonic acid, was observed in the high-pressure diamond-anvil cell. The pressure-temperature paths of both its melting and peritectic curves were measured, beginning at 4.4 GPa and 165 °C (where it exists in a quadruple equilibrium, together with an aqueous fluid and the ices H2O(VII) and CO2(I)) and proceeding to higher pressures and temperatures. Single-crystal X-ray diffraction revealed a triclinic crystal with unit cell parameters (at 6.5 GPa and 20 °C) of a = 5.88 Å, b = 6.59 Å, c = 6.99 Å, α = 88.7°, β = 79.7°, and γ = 67.7°. Raman spectra exhibit a major line at ~1080 cm−1 and lattice modes below 300 cm−1.
Biochemistry of malaria parasite infected red blood cells by X-ray microscopy
Authors: Kapishnikov S. , Leiserowitz L. , Yang Y. , Cloetens P. , Pereiro E. , Awamu Ndonglack F. , Matuschewski K. , Als-Nielsen J.
Published: April 2017

Red blood cells infected by the malaria parasite Plasmodium falciparum are correlatively imaged by tomography using soft X-rays as well as by scanning hard nano-X-ray beam to obtain fluorescence maps of various elements such as S and Fe. In this way one can deduce the amount of Fe bound either in hemoglobin or in hemozoin crystals in the digestive vacuole of the malaria parasite as well as determine the hemoglobin concentrations in the cytosols of the red blood cell and of the parasite. Fluorescence map of K shows that in the parasite’s schizont stage the K concentration in the red blood cell cytosol is diminished by a factor of seven relative to a pristine red blood cell but the total amount of K in the infected red blood cell is the same as in the pristine red blood cell.
Effects of root spatial distribution on the elastic-plastic properties of soil-root blocks
Authors: Li Yunpeng , Wang Yunqi , Wang Yujie , Ma Chao
Published: April 2017

Plant roots significantly influence soil properties, especially in soil beyond the limited area surrounding the main root stem. Some bias results may be generated if plastic properties of soil are merely used in evaluating slope stability without considering the effects of plant roots. In this research, effects of root spatial distribution on the elastic-plastic characteristics of soil-root blocks were examined. Triaxial tests and the Duncan-Chang model were used to analyze the correlation between root spatial characteristics and soil elastic-plastic properties. Safety factors of vegetated slopes were calculated to investigate the effect of roots on slope stability. The limit stress of remoulded soil was 103.52% to 231.61% greater than undisturbed soil in shallow soil layers. Increased root quantity led to an increased the failure ratio of soil bulk and the initial tangent modulus increased with root diameter. When calculating the safety factor of vegetated slopes, soil indexes for soil beyond the small cylinder surrounding the main stem should be properly considered to avoid safety factor overestimation.
A universal primer-independent next-generation sequencing approach for investigations of norovirus outbreaks and novel variants
Authors: Fonager Jannik , Stegger Marc , Rasmussen Lasse Dam , Poulsen Mille Weismann , Rønn Jesper , Andersen Paal Skytt , Fischer Thea Kølsen
Published: April 2017

Norovirus (NoV) is the most common cause of non-bacterial gastroenteritis and is a major agent associated with outbreaks of gastroenteritis. Conventional molecular genotyping analysis of NoV, used for the identification of transmission routes, relies on standard typing methods (STM) by Sanger-sequencing of only a limited part of the NoV genome, which could lead to wrong conclusions. Here, we combined a NoV capture method with next generation sequencing (NGS), which increased the proportion of norovirus reads by ~40 fold compared to NGS without prior capture. Of 15 NoV samples from 6 single-genotype outbreaks, near full-genome coverage (>90%) was obtained from 9 samples. Fourteen polymerase (RdRp) and 15 capsid (cap) genotypes were identified compared to 12 and 13 for the STM, respectively. Analysis of 9 samples from two mixed-genotype outbreaks identified 6 RdRp and 6 cap genotypes (two at >90% NoV genome coverage) compared to 4 and 2 for the STM, respectively. Furthermore, complete or partial sequences from the P2 hypervariable region were obtained from 7 of 8 outbreaks and a new NoV recombinant was identified. This approach could therefore strengthen outbreak investigations and could be applied to other important viruses in stool samples such as hepatitis A and enterovirus.
The Neuromuscular Origins of Kinematic Variability during Perturbed Walking
Authors: Stokes Heather E. , Thompson Jessica D. , Franz Jason R.
Published: April 2017

We investigated the neuromuscular contributions to kinematic variability and thus step to step adjustments in posture and foot placement across a range of walking speeds in response to optical flow perturbations of different amplitudes using a custom virtual environment. We found that perturbations significantly increased step width, decreased step length, and elicited larger trunk sway compared to normal walking. However, perturbation-induced effects on the corresponding variabilities of these measurements were much more profound. Consistent with our hypotheses, we found that: (1) perturbations increased EMG activity of the gluteus medius and postural control muscles during leg swing, and increased antagonist leg muscle coactivation during limb loading in early stance, and (2) changes in the magnitude of step to step adjustments in postural sway and lateral foot placement positively correlated with those of postural control and gluteus medius muscle activities, respectively, in response to perturbations. However, (3) interactions between walking speed and susceptibility to perturbations, when present, were more complex than anticipated. Our study provides important mechanistic neuromuscular insight into walking balance control and important reference values for the emergence of balance impairment.
Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
Authors: Papadacci Clement , Finel Victor , Provost Jean , Villemain Olivier , Bruneval Patrick , Gennisson Jean-Luc , Tanter Mickael , Fink Mathias , Pernot Mathieu
Published: April 2017

The assessment of myocardial fiber disarray is of major interest for the study of the progression of myocardial disease. However, time-resolved imaging of the myocardial structure remains unavailable in clinical practice. In this study, we introduce 3D Backscatter Tensor Imaging (3D-BTI), an entirely novel ultrasound-based imaging technique that can map the myocardial fibers orientation and its dynamics with a temporal resolution of 10 ms during a single cardiac cycle, non-invasively and in vivo in entire volumes. 3D-BTI is based on ultrafast volumetric ultrasound acquisitions, which are used to quantify the spatial coherence of backscattered echoes at each point of the volume. The capability of 3D-BTI to map the fibers orientation was evaluated in vitro in 5 myocardial samples. The helicoidal transmural variation of fiber angles was in good agreement with the one obtained by histological analysis. 3D-BTI was then performed to map the fiber orientation dynamics in vivo in the beating heart of an open-chest sheep at a volume rate of 90 volumes/s. Finally, the clinical feasibility of 3D-BTI was shown on a healthy volunteer. These initial results indicate that 3D-BTI could become a fully non-invasive technique to assess myocardial disarray at the bedside of patients.