bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanical circulatory support: balancing bleeding and clotting in high-risk patients
Authors: Baumann Kreuziger Lisa , Massicotte M. Patricia
Published: September 2016

Mechanical circulatory support (MCS) provides a bridge to heart transplant in children and adults with life-threatening heart failure and sustains patients ineligible for transplant. Extracorporeal membrane oxygenation (ECMO) provides temporary support for patients in cardiac or pulmonary failure through external gas exchange and continuous flow of blood. Because the median time to heart transplant exceeds event-free time on ECMO, pulsatile left ventricular assist devices (LVADs) are used to support infants and children. Continuous flow LVADs are preferred in adolescents and adults due to increased pump durability and improved overall survival. The shear stress created by the mechanical pumps cause changes in the hematologic system; acquired von Willebrand syndrome occurs in almost all patients treated with MCS. Despite the improvements in survival, major bleeding occurs in one-third of patients with a LVAD and ischemic stroke and LVAD thrombosis can affect 12% of adults and 29% of children. An antithrombotic strategy to mitigate LVAD bleeding and thrombotic complications has been tested in a randomized trial in children, but intensity of antithrombotic therapy in adults varies widely. Consensus guidelines for antithrombotic therapy during ECMO were created due to significant differences in management across centers. Because of the high risk for both bleeding and thrombotic complications, experts in hemostasis can significantly impact care of patients requiring mechanical circulatory support and are a necessary part of the management team.
Checkpoint blockade in lymphoma
Authors: Armand Philippe
Published: September 2016

Immune checkpoint blockade therapy (CBT) was born of the combination of several elements: the understanding of some of the important immune regulation pathways in humans; the recognition that tumors can engage those pathways to evade immune responses; and the clinical development of monoclonal antibodies targeting checkpoint receptors to restore effective anti-tumor immunity. This form of therapy, focused to date mostly on the cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmed-death 1 (PD-1) pathways, has already revolutionized the treatment of several solid tumors. Hematologic malignancies (HMs) offer a promising testing ground for this strategy, and several trials have already demonstrated evidence of therapeutic activity with checkpoint blockade, especially in lymphoma. This review will discuss the current clinical results of CBT in lymphoma in the context of their scientific underpinning, and build from this summary a projection of how the field may evolve in the near future.
EnsCat: clustering of categorical data via ensembling
Authors: Clarke Bertrand S. , Amiri Saeid , Clarke Jennifer L.
Published: September 2016

Background

Clustering is a widely used collection of unsupervised learning techniques for identifying natural classes within a data set. It is often used in bioinformatics to infer population substructure. Genomic data are often categorical and high dimensional, e.g., long sequences of nucleotides. This makes inference challenging: The distance metric is often not well-defined on categorical data; running time for computations using high dimensional data can be considerable; and the Curse of Dimensionality often impedes the interpretation of the results. Up to the present, however, the literature and software addressing clustering for categorical data has not yet led to a standard approach.

Results

We present software for an ensemble method that performs well in comparison with other methods regardless of the dimensionality of the data. In an ensemble method a variety of instantiations of a statistical object are found and then combined into a consensus value. It has been known for decades that ensembling generally outperforms the components that comprise it in many settings. Here, we apply this ensembling principle to clustering.

We begin by generating many hierarchical clusterings with different clustering sizes. When the dimension of the data is high, we also randomly select subspaces also of variable size, to generate clusterings. Then, we combine these clusterings into a single membership matrix and use this to obtain a new, ensembled dissimilarity matrix using Hamming distance.

Conclusions

Ensemble clustering, as implemented in and called , gives more clearly separated clusters than other clustering techniques for categorical data. The latest version with manual and examples is available at https://github.com/jlp2duke/EnsCat.
Large-scale localization of touching somas from 3D images using density-peak clustering
Authors: Cheng Shenghua , Quan Tingwei , Liu Xiaomao , Zeng Shaoqun
Published: September 2016

Background

Soma localization is an important step in computational neuroscience to map neuronal circuits. However, locating somas from large-scale and complicated datasets is challenging. The challenges primarily originate from the dense distribution of somas, the diversity of soma sizes and the inhomogeneity of image contrast.

Results

We proposed a novel localization method based on density-peak clustering. In this method, we introduced two quantities (the local density ρ of each voxel and its minimum distance δ from voxels of higher density) to describe the soma imaging signal, and developed an automatic algorithm to identify the soma positions from the feature space (ρ, δ). Compared with other methods focused on high local density, our method allowed the soma center to be characterized by high local density and large minimum distance. The simulation results indicated that our method had a strong ability to locate the densely positioned somas and strong robustness of the key parameter for the localization. From the analysis of the experimental datasets, we demonstrated that our method was effective at locating somas from large-scale and complicated datasets, and was superior to current state-of-the-art methods for the localization of densely positioned somas.

Conclusions

Our method effectively located somas from large-scale and complicated datasets. Furthermore, we demonstrated the strong robustness of the key parameter for the localization and its effectiveness at a low signal-to-noise ratio (SNR) level. Thus, the method provides an effective tool for the neuroscience community to quantify the spatial distribution of neurons and the morphologies of somas.
RETRACTED ARTICLE: A candidate Chinese medicine preparation-Fructus Viticis Total Flavonoids inhibits stem-like characteristics of lung cancer stem-like cells
Authors: Cao Xiaocheng , Zou Hui , Cao Jianguo , Cui Yinghong , Sun Shuwen , Ren Kaiqun , Song Zhenwei , Li Duo , Quan Meifang
Published: September 2016

Background

Cancer stem cells (CSCs) are considered as the origin of tumor relapse. Here, we investigated the effects of Fructus Viticis total flavonoids (FVTF) on the characteristics of lung cancer stem-like cells (LCSLCs) derived from human small cell lung cancer NCI-H446 cell line and its potential mechanism.

Methods

Human small cell lung cancer NCI-H446 cell line was cultured in vitro. The CD133+ cells were sorted from NCI-H446 cell line by magnetic separation.

The suspended culture with stem cell-conditioned medium was used to amplify CD133+ sphere-forming cells (SFCs). The stem cell characteristics of CD133+ SFCs were evaluated using cell self-renewal capacity by tumor sphere formation assay, migration and invasion capacity by Transwell assay, tumorigenicity by xenograft model in nude mouse and cancer stem cell markers expression levels by western blot. The effects of FVTF on the properties of LCSLCs were examined by tumorsphere formation assay and transwell chamber assay. The expression level of p-Akt was determined by western blot analysis.

Result

CD133+ SFCs derived from human small cell lung cancer NCI-H446 cells exhibited stemness properties of tumorsphere formation and tumorigenesis capacity comparing to the parental cells. FVTF relative selectively inhibited the proliferation of LCSLCs, suppressed tumor sphere forming capacity and migration and invasion of LCSLCs, and down-regulated the protein expression of stem cell markers (CD133, CD44 and ALDH1), self-renewal associated transcription factors (Bmi1, Nanog and OCT4) and invasion associated transcription factors (Twist1 and Snail1) in a dose-dependent manner. Moreover, we found that FVTF treatment could significantly decrease the phosphorylation level of Akt in LCSLCs. Meanwhile, LY294002 and FVTF synergistically inhibited the characteristics of LCSLCs.

Conclusion

FVTF inhibits the characteristics of LCSLCs through down-regulating expression of p-Akt.
Ultrasonographic examination of plantar fasciitis: a comparison of patient positions during examination
Authors: Ahn Jae Hoon , Lee Choong Woo , Park ChanJoo , Kim Yoon‐Chung
Published: September 2016

Background

Musculoskeletal ultrasound is a non‐invasive and low‐cost modality for real‐time visualisation of the plantar fascia. Ultrasound examination for plantar fasciitis is generally performed with the patient in a prone position, although the rational for using a prone position has not been validated. The aim of the study was to investigate if ultrasound examination in a supine position, which is more comfortable than the prone position, is valid.

Methods

We conducted a prospective study of 30 participants with plantar fasciitis, 8 men (27 %) and 22 women (73 %), with a mean age of 53.9 ± 12.6 (range, 32 to 77) years, and an equal distribution of left and right feet. The plantar heel was divided into three portions for ultrasound examination: medial, central and lateral. Two measurements of plantar fascia thickness were obtained for each portion, with participants in 2 positions (supine and prone) and for 2 ankle postures (neutral and 15° of plantarflexion). Mean measurements of plantar fascia thickness were compared between the two positions (Wilcoxon signed rank tests for non‐normally distributed data and paired t‐tests for normally distributed data). Participants were asked to report their preferred position for examination, supine or prone.

Results

The measured thickness was comparable for both supine and prone positions, for both ankle postures, neutral and 15° of plantarflexion (p > 0.05). A specific self‐reported preferred position was not identified.

Conclusions

Ultrasound examination of plantar fasciitis can be performed in the supine position without any significant difference in measurement compared to examination in the conventional prone position.

Trial registration

The Catholic Medical Center Office of Human Research Protection Program (CMC‐OHRP)/Institutional Review Board approved the current study (Approval No. KC12DISI0338), and all participants provided their written informed consent for participation and publication.
Mental practice in postgraduate training: A randomized controlled trial in mastoidectomy skills
Authors: Conlin Anne , Lea Jane , Bance Manohar , Chadha Neil , Kilty Shaun , Kozak Frederick , Savage Julian , Sidhu Ravindar , Chen Joseph , Westerberg Brian D.
Published: September 2016

Background

Mental practice, the cognitive rehearsal of a task in the absence of overt physical movement, has been successfully used in teaching complex psychomotor tasks including sports and music, and recently, surgical skills. The objectives of this study were, 1) To develop and evaluate a mental practice protocol for mastoidectomy 2) To assess the immediate impact of mental practice on a mastoidectomy surgical task among senior Otolaryngology─Head & Neck Surgery (OHNS) residents.

Method

Three expert surgeons were interviewed using verbal protocol analysis to develop a mastoidectomy mental practice script. Twelve senior Residents from Canadian training programs were randomized into two groups. All Residents were video-recorded performing a baseline mastoidectomy in a temporal bone lab. The intervention group received mental practice training, while the control group undertook self-directed textbook study. All subjects were then video-recorded performing a second mastoidectomy. Changes in pre- and post-test scores using validated expert ratings, the Task Specific Evaluation of Mastoidectomy and the Global Evaluation of Mastoidectomy, were statistically analyzed.

Results

A mental practice script was successfully developed based on interviews of three expert surgeon-educators. Task Specific Evaluation and Global Evaluation scores increased in both the mental practice and textbook study groups; there was no significant difference between the two groups in the change in scores post-intervention. There was a high and statistically signficant correlation between evaluators on the outcome measures.

Conclusions

We were not able to demonstrate a significant difference for the benefits of mental practice in mastoidectomy, possibly due to the sample size. However, mental practice is a surgical education tool which is portable, accessible, inexpensive and safe.
Deceleration of probe beam by stage bias potential improves resolution of serial block-face scanning electron microscopic images
Authors: Bouwer James C. , Deerinck Thomas J. , Bushong Eric , Astakhov Vadim , Ramachandra Ranjan , Peltier Steven T. , Ellisman Mark H.
Published: September 2016

Serial block-face scanning electron microscopy (SBEM) is quickly becoming an important imaging tool to explore three-dimensional biological structure across spatial scales. At probe-beam-electron energies of 2.0 keV or lower, the axial resolution should improve, because there is less primary electron penetration into the block face. More specifically, at these lower energies, the interaction volume is much smaller, and therefore, surface detail is more highly resolved. However, the backscattered electron yield for metal contrast agents and the backscattered electron detector sensitivity are both sub-optimal at these lower energies, thus negating the gain in axial resolution. We found that the application of a negative voltage (reversal potential) applied to a modified SBEM stage creates a tunable electric field at the sample. This field can be used to decrease the probe-beam-landing energy and, at the same time, alter the trajectory of the signal to increase the signal collected by the detector. With decelerated low landing-energy electrons, we observed that the probe-beam-electron-penetration depth was reduced to less than 30 nm in epoxy-embedded biological specimens. Concurrently, a large increase in recorded signal occurred due to the re-acceleration of BSEs in the bias field towards the objective pole piece where the detector is located. By tuning the bias field, we were able to manipulate the trajectories of the  primary and secondary electrons, enabling the spatial discrimination of these signals using an advanced ring-type BSE detector configuration or a standard monolithic BSE detector coupled with a blocking aperture.
Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia
Authors: Shindo Yuichiro , Fuchs Anja G , Davis Christopher G , Eitas Tim , Unsinger Jacqueline , Burnham Carey-Ann D , Green Jonathan M , Morre Michel , Bochicchio Grant V , Hotchkiss Richard S
Published: September 2016

Patients with protracted sepsis develop impaired immunity, which predisposes them to acquiring secondary infections. One of the most common and lethal secondary infections is Pseudomonas aeruginosa pneumonia. Immunoadjuvant therapy is a promising approach to reverse sepsis-induced immunosuppression and improve morbidity and mortality from secondary infections. Interleukin-7 is an immunoadjuvant that improves survival in clinically relevant animal models of polymicrobial peritonitis and in fungal sepsis. This study investigated the effect of recombinant human interleukin-7 (rhIL-7) on survival in a 2-hit model of sublethal cecal ligation and puncture followed by P. aeruginosa pneumonia. Potential immunologic mechanisms responsible for the rhIL-7 putative beneficial effect were also examined, focusing on IL-17, IL-22, IFN-γ, and TNF-α, cytokines that are critical in the control of sepsis and pulmonary Pseudomonas infections. Results showed that rhIL-7 was highly effective in preventing P. aeruginosa–induced death, i.e., 92% survival in rhIL-7–treated mice versus 56% survival in control mice. rhIL-7 increased absolute numbers of immune effector cells in lung and spleen and ameliorated the sepsis-induced loss of lung innate lymphoid cells (ILCs). rhIL-7 also significantly increased IL-17–, IFN-γ–, and TNF-α–producing lung ILCs and CD8 T cells as well as IFN-γ– and TNF-α–producing splenic T cell subsets and ILCs. Furthermore, rhIL-7 enhanced NF-κB and STAT3 signaling in lungs during sepsis and pneumonia. Given the high mortality associated with secondary P. aeruginosa pneumonia, the ability of rhIL-7 to improve immunity and increase survival in multiple animal models of sepsis, and the remarkable safety profile of rhIL-7, clinical trials with rhIL-7 should be considered.
CD4+ T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood
Authors: Schoknecht Tanja , Schwinge Dorothee , Stein Stephanie , Weiler-Normann Christina , Sebode Marcial , Mucha Sören , Otto Benjamin , Ellinghaus Eva , Stahl Felix , Franke Andre , Lohse Ansgar W , Herkel Johannes , Schramm Christoph
Published: September 2016

The pathogenesis of the progressive liver disease, primary sclerosing cholangitis (PSC), remains largely elusive. The strong genetic association with HLA loci suggests that T cell–dependent, adaptive immune reactions could contribute to disease pathogenesis. Recent studies have indicated that PSC is also associated with polymorphisms in the locus encoding for proapoptotic Bim (BCL2L11). Bim is crucial for the maintenance of immunologic tolerance through induction of apoptosis in activated T cells. Of interest with regard to PSC is the finding that BCL2L11-deficient mice develop periductular infiltrates. We, therefore, investigated, whether defective apoptosis of T cells might contribute to the phenotype of PSC. Thus, we induced apoptosis of T cells from patients with PSC and controls by repeated T cell receptor (TCR) stimulation or cytokine withdrawal. We found that CD4+ T cells, but not CD8+ T cells, from patients with PSC exhibited significantly reduced apoptosis in response to both, TCR restimulation or cytokine withdrawal. This increased apoptosis resistance was associated with significantly reduced up-regulation of proapoptotic Bim in T cells from patients with PSC. However, T cell apoptosis did not seem to be influenced by the previously described BCL2L11 polymorphisms. Reduced CD4+ T cell apoptosis in patients with PSC was not due to reduced cell activation, as indicated by a similar surface expression of the activation markers CD69, CD25, and CD28 in T cells from patients and controls. Thus, decreased apoptosis of activated CD4+ T cells may be part of the immune dysregulation observed in patients with PSC.
Investigation of collar properties on data-acquisition scheme for acoustic logging-while-drilling
Authors: Wang Hua , Fehler Mike , Tao Guo , Wei Zhoutuo
Published: September 2016

We have used the wavenumber integration, velocity-time semblance, and dispersion methods to investigate the influence of collar properties including velocities, density, and attenuation on acoustic logging-while-drilling wavefields. We have found that when the velocities of the collar wave and the P-wave of the formation are similar, they interfere. However, the interference disappears when the velocity difference increases. Having a collar with large velocities (especial large shear velocity) and density makes the direct P-velocity determination possible in a fast formation even without isolators. For a slow formation, the interference of the collar flexural wave with the formation flexural and leaky P-waves is slight for a dipole tool when collar velocities are large. For this case, the S velocity can be determined by the flexural formation wave at low frequency (approximately 2 kHz). Based on these observations, we propose that the measurement of the P- and S-velocities can be easier if the collar is made of an advanced composite material that has high compressional and shear velocities as well as density. This is a direct and easy change to implement and a new idea for an acoustic logging-while-drilling tool design.
Reflector imaging using trial reflector and crosscorrelation: Application to fracture imaging for sonic data
Authors: Hirabayashi Nobuyasu
Published: September 2016

I have developed two high-resolution imaging methods that do not require a priori information on the structural dip. The dip information is often necessary to image complex structures using Kirchhoff migration by selecting only the constructively interfering parts of waveforms, especially for data with limited acquisition geometry. However, such dip information is not generally available. The methods that I evaluated use a trial reflector, which is defined for each image point and source-receiver pair, to search for the true geologic reflector. The coincidence of these reflectors is judged by a coherency analysis of event signals for the trial reflector using the crosscorrelations, and the coherency is converted to a weight. The weight is combined with the stacking methods of waveform samples in migration. In the first method, a waveform sample summed at an image point for a source-receiver pair is obtained by the common-depth-point stack of array data for the trial reflector. In the second method, a waveform sample of a source-receiver pair at the traveltime of the reflected ray for the trial reflector is smeared in the Fresnel zone computed for the trial reflector. My methods were applied to image fractures for sonic data, whose frequency range is centered approximately 8 kHz, and they provide higher resolution images than those given by conventional Kirchhoff migration.
Racial Differences in Association of Serum Calcium with Mortality and Incident Cardio- and Cerebrovascular Events
Authors: Lu Jun Ling , Molnar Miklos Z. , Ma Jennie Z. , George Lekha K. , Sumida Keiichi , Kalantar-Zadeh Kamyar , Kovesdy Csaba P.
Published: September 2016

Context:

Abnormalities in calcium metabolism may potentially contribute to the development of vascular disease. Calcium metabolism may be different in African American (AA) vs white individuals, but the effect of race on the association of serum calcium with clinical outcomes remains unclear.

Objective:

This study sought to examine race-specific associations of serum calcium levels with mortality and with major incident cardiovascular events.

Design and Setting:

This was a historical cohort study in the U.S. Department of Veterans Affairs health care facilities.

Participants:

Participants included veterans (n = 1 967 622) with estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2.

Main Outcome Measures:

The association between serum calcium levels with all-cause mortality, incident coronary heart disease (CHD), and ischemic stroke incidence was examined in multivariable adjusted Cox proportional hazards models, including an interaction term for calcium and race.

Results:

The association of calcium with all-cause mortality was U-shaped in both AA and white patients, but race modified the association of calcium with all-cause mortality. Compared with white patients, AA patients experienced lower risk of mortality when calcium was ≥ 8.8 mg/dL, with a statistically significant interaction (P < .001). Conversely, AA vs white race was associated with higher mortality when calcium was < 8.8 mg/dL. Calcium showed no significant association with ischemic stroke or CHD in both races; and race did not modify these associations (P = .37 and 0.11, respectively for interaction term).

Conclusions:

Race modified the U-shaped association between calcium and all-cause mortality. Serum calcium is not associated with incident stroke or CHD in either AA or white patients. The race-specific difference in the association of calcium levels with mortality warrants further examination.
LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes
Authors: Hubert Virginie , Peschel Andrea , Langer Brigitte , Gröger Marion , Rees Andrew , Kain Renate
Published: September 2016

Autophagy is an evolutionarily conserved process used for removing surplus and damaged proteins and organelles from the cytoplasm. The unwanted material is incorporated into autophagosomes that eventually fuse with lysosomes, leading to the degradation of their cargo. The fusion event is mediated by the interaction between the Qa-SNARE syntaxin-17 (STX17) on autophagosomes and the R-SNARE VAMP8 on lysosomes. Cells deficient in lysosome membrane-associated protein-2 (LAMP-2) have increased numbers of autophagosomes but the underlying mechanism is poorly understood. By transfecting LAMP-2-deficient and LAMP-1/2­-double-deficient mouse embryonic fibroblasts (MEFs) with a tandem fluorescent-tagged LC3 we observed a failure of fusion between the autophagosomes and the lysosomes that could be rescued by complementation with LAMP-2A. Although we observed no change in expression and localization of VAMP8, its interacting partner STX17 was absent from autophagosomes of LAMP-2-deficient cells. Thus, LAMP-2 is essential for STX17 expression by the autophagosomes and this absence is sufficient to explain their failure to fuse with lysosomes. The results have clear implications for situations associated with a reduction of LAMP-2 expression.
Development and interval testing of a naturalistic driving methodology to evaluate driving behavior in clinical research
Authors: Babulal Ganesh M. , Addison Aaron , Ghoshal Nupur , Stout Sarah H. , Vernon Elizabeth K. , Sellan Mark , Roe Catherine M.
Published: September 2016

Background: The number of older adults in the United States will double by 2056. Additionally, the number of licensed drivers will increase along with extended driving-life expectancy. Motor vehicle crashes are a leading cause of injury and death in older adults. Alzheimer’s disease (AD) also negatively impacts driving ability and increases crash risk. Conventional methods to evaluate driving ability are limited in predicting decline among older adults. Innovations in GPS hardware and software can monitor driving behavior in the actual environments people drive in. Commercial off-the-shelf (COTS) devices are affordable, easy to install and capture large volumes of data in real-time. However, adapting these methodologies for research can be challenging. This study sought to adapt a COTS device and determine an interval that produced accurate data on the actual route driven for use in future studies involving older adults with and without AD. 

Methods: Three subjects drove a single course in different vehicles at different intervals (30, 60 and 120 seconds), at different times of day, morning (9:00-11:59AM), afternoon (2:00-5:00PM) and night (7:00-10pm). The nine datasets were examined to determine the optimal collection interval.

Results: Compared to the 120-second and 60-second intervals, the 30-second interval was optimal in capturing the actual route driven along with the lowest number of incorrect paths and affordability weighing considerations for data storage and curation.

Discussion: Use of COTS devices offers minimal installation efforts, unobtrusive monitoring and discreet data extraction.  However, these devices require strict protocols and controlled testing for adoption into research paradigms.  After reliability and validity testing, these devices may provide valuable insight into daily driving behaviors and intraindividual change over time for populations of older adults with and without AD.  Data can be aggregated over time to look at changes or adverse events and ascertain if decline in performance is occurring.
EVENT TOURISM AND INTANGIBLE CULTURAL HERITAGE (THE CASE OF VLADIMIR REGION)
Authors: Шерешева Марина , Sheresheva Marina
Published: September 2016

Differences in national cultures and unique cultural heritage are among the main drivers of international tourism de- velopment. There is faster growth and more noticeable specialization in this segment of the tourism market. In recent years, there is increased attention to the role of event tourism as an efficient way to engage elements of intangible cultural heritage to the organization of travelers’ leisure, and thus to increase tourist flows while minimizing damage to the environment and the material cultural heritage. The article presents the results of a study conducted in Vladimir region by means of expert interviews and case study. The analysis has shown that a year-round calendar of event tour- ism, based on attracted intangible cultural heritage, contributes to the interest of tourists for the first destination visit and helps to create a basis for increasing the repeat visits share. Moreover, it helps to solve a set of interrelated issues, including inventory and preservation of intangible cultural heritage and to balance the interests of all destination stake- holders (business actors, tourists, residents, governmental and municipal bodies). It is possible to reduce unevenness of tourist flows in time and space, and to overcome the problem of Vladimir-Suzdal Museum Reserve limiting possibilities to serve growing visitors flow without damaging the material cultural heritage included in the UNESCO list.
INTANGIBLE CULTURAL HERITAGE OF BELGOROD REGION: PROBLEMS OF INVOLVING IN THE TOURISM SECTOR
Authors: Жиленко Вилена , Zhilenko Vilena
Published: September 2016

The article substantiates the necessity for discovering and preservation the intangible cultural heritage and the importance of the developing the legal framework in the field of intangible cultural heritage. The author gives recommenda- tion how to increase the flow of tourists through their learning the intangible cultural heritage and involvement in the rituals and festive events, folk arts and crafts. The article analyzes not only a positive effect on the intangible cultural heritage, but also presents the factors of negative impact. The recommendations how to reduce and minimize their impact are given. The analysis of the problems of involving intangible cultural heritage of Belgorod region in tourism is the aim of the study. This revealed development prospects of such types of tourism as ethnographic and event tourism. Based on the existing inventory of intangible cultural heritage of Belgorod region the author assesses the potential for tourism development based on intangible cultural heritage. The most promising areas of Belgorod region, having the greatest potential for development of tourism based on intangible cultural heritage, are selected. The most valuable objects of intangible cultural heritage of Rakityansky and Chernyansky districts with the greatest potential for tourism based on the intangible cultural heritage are described and identified. Analysis of the major problems of involving the intangible cultural heritage of Belgorod region in tourism has been carried out. Statistical methods, theoretical and problem analysis are the main for the study. As the research result, the set of measures to preserve and secure involvement of the intangible cultural heritage in tourism of Belgorod region has been developed.
EVENT TOURISM: THE EXPERIENCE OF INVOLVING THE INTANGIBLE CULTURAL HERITAGE OF THE REPUBLIC OF TATARSTAN IN TOURISM
Authors: Чинкина Дахия , Chinkina Dakhiya , Мухаметова Ландыш , Mukhametova Landysh , Розанова Лада , Rozanova Lada
Published: September 2016

The article presents the analysis of the involvement of the intangible cultural heritage of the Republic of Tatarstan in tourism. Tremendous opportunities in this regard offer the organization of tourist events on the basis of cultural events. Event tourism is today one of the most rapidly developing types of tourism, whose turnover has grown to billions of dollars. The leading tourism regions of Russia, as well as the provinces demonstrate the growing number and attractiveness of tourism eventsfrom the Olympics Games in Sochi to the festival of folk crafts «Vyatskiy Lapot» in Kirov region. Vast expanses of Russia, the variety of natural landscapes, national and religious traditions of the population, rich history creating the preconditions for an infinite number of variants of transformation of cultural heritage in colorful tourism events.

The Republic of Tatarstan, being one of the most economically and socially developed regions in Russia, shows in recent years high rates of the tourism industry development. Due to major sporting and cultural events a modern tourism infra- structure has been created here – transport, hotel, information, etc. Great attention is paid to the development of event tourism in the Republic, beginning with the ancient national holidays of peoples of Tatarstan, ending with «newborn» festivals of Medieval weapons in Ancient Bolgar and gastronomic festival «Delicious Kazan». Not coincidentally, Kazan became a leader among cities of Russia by reception of foreign tourists, taking in the winter of 2016 the third place after the two capitals. The article focuses on evenrelated activities that have a significant potential to become a powerful tourist attractors for the Republic of Tatarstan.
CULTURAL OFFICES IN PRESERVATION AND DEVELOPMENT OF ETHNOTERRITORIES OF THE REPUBLIC OF KARELIA
Authors: Дьяконова Мария , Dyakonova Mariya , Степанова Светлана , Stepanova Svetlana
Published: September 2016

In the territory of the Republic of Karelia now live three aboriginal people – karelians, russian, vepsians, who created unique and original culture. Residing of ethnic groups – territorially-localised historically developed on the basis of eco- nomic way of ethnos rural settlements that are characterized by domination of traditional forms of economic activities, use of handicraft crafts, cottage industry.

Problems of the labour market and the youth’s position in it are especially acute in rural areas due to reforms and changes in the system of economic relations in the agrarian and forest sectors, and local administration. Difficulties of life in coun- tryside influence on the vital self-determination of youth, promoting strengthening of youth migration in the central part of Republic of Karelia and the Russian Federation. In this connection one of the actual questions is the perspectives of rural settlements development, labour potential of which is a basis of economic life, and self-development of territories. Tourism now appears as one of promising lines for regional development in the Republic of Karelia, which can mitigate social problems, and act as a factor for conservation and reproduction of the natural, historical and cultural potential of the territory. One of promising directions of rural tourism growth is development of the ethnographic tourism based on visiting ethnographic sites for the purpose of knowledge of traditional folklife culture: traditions, culture and a life of the people, the ethnos living on the certain territory. Full-fledged development of the tourism business is only possible if the youth are involved in this sphere of economic activity, recognize its importance, and perceive it as a resource for their life strategy. The work was executed under government order «The role of human capital in a dilemma: the new economic theories – modern challenges».
PROBLEMS AND PROSPECTS OF INVOLVEMENT OF SYMBOLIC RESOURCES IN TOURISM (THE CASE OF PERM KRAY)
Authors: Ширинкин Павел , Shirinkin Pavel
Published: September 2016

The article analyses aspects of the development of human and cultural geography and the concepts of «geographic image of a territory» and «cultural landscape». From the point of view of modern tourist requirements it is necessary to allocate along with the natural and historical-cultural the symbolic resources of tourism. The author agrees with experts that offer productive symbiosis of geography and mythogeography when such studies are part of humanitarian-geographical and cultural developments. The study of spatial representations produced by them, and geographical images and any other interpretations of the space, is of great interest in applied key. Based on the structural-semiotic approach the legend can be considered as an ancient symbolic form, so the myths of a particular area are not only a basic part of the symbolic resources, but also access to the group of potential customers in tourism. Legends of specific places, is the basis for the emergence of tourist motive and trip. Popular tourism legend or myth, used in socicultural design, is often superior to the real tourist attractiveness of the territory, with the prospects of regional image and brand. Involving the legends in tourism, in turn, are encouraged to consider as the practical direction of cultural geography and an effective marketing mechanism for the tourism development of a territory, its image and way to attract potential consumers, who perceive geographical space as the images of various degrees of subjectivity. Using the example of Perm region the author demonstrates the problems and prospects of involvement of symbolic resources in regional tourism, in which myths and legends play an important role.
Aplikasi Metode Self Potential untuk Pemetaan Sebaran Lindi di Wilayah Tempat Pembuangan Akhir (TPA) Putri Cempo Surakarta
Authors: Handoko Andri Wasis , Darsono D , Darmanto D
Published: September 2016

The distribution of leachate and the pattern of fluid flow in Tempat Pembuangan Akhir (TPA) Putri Cempo were mapped by utilizing the Self Potential method. Data acquisition was done before and after the rain with a fixed base techniques with 10 meters interval distance with total number of observations were 78 points for data acquisition. SP Data were processed using Surfer 11 software to generate the isopotential contours. It is found that the leachate distribution anomaly is indicated only for after the rain observation. Interpretation was done by Rao and Ram Babu Theory. The result of vertical spreading of anomalous 1 was found at the depth of the upper end (h) 5.45 meters, the depth of the lower end (H) 17.62 meters and the angle of anomaly (θ) 840 while the anomalous 2 was found at the depth of the upper end (h) 5.45 meters, the depth of the lower end (H) 11.22 meters and the angle of anomaly (θ) 73.70. At the time before the rain, the pattern of fluid flow leading to the eastern part of the research area, while after the rain, the fluid flow coming from two directions, from the west and from the east of the research area leading to the central part of the research area.
PLANEJAMENTO DO TURISMO SOB A PERSPECTIVA DA ANÁLISE ESPACIAL: um estudo em Paranapiacaba/SP
Authors: Suzart Vanessa , Ribeiro Renata Maria , Moraes Ewerton Henrique
Published: September 2016

O presente artigo apresenta a importância do planejamento do turismo sob a perspectiva da análise espacial na vila de Paranapiacaba/SP, tendo como objetivo analisar e mapear os recursos e atrativos existentes. Para isso, utilizamos estudos teóricos sobre a analise espacial e o planejamento físico, assim como o uso da ferramenta Google Earth. A aplicação da teoria do espaço turístico no mapa de Paranapiacaba é relevante, visto que a oferta turística e sua demanda dependem do planejamento físico. Palavras-chave: Planejamento do Turismo. Análise espacial. Paranapiacaba. Espaço Turístico.
OS MOTÉIS EM CAMPO MOURÃO-PR COMO OPÇÃO PARA HOSPEDAGEM E EVENTOS
Authors: Angeli Aline
Published: September 2016

Esta pesquisa buscou analisar nos sete motéis da cidade de Campo Mourão-PR, as condições para hospedagem de turistas e os espaços para a realização de eventos. Para isso foram avaliados os serviços ofertados, a infraestrutura disponível, o interesse do cliente e a viabilidade do uso dos motéis para a realização de eventos e hospedagem. Como metodologia de pesquisa, foram utilizados: o levantamento histórico e legal dos motéis; a observação como cliente oculto; pesquisa através de rede social e e-mail; e, por m, a entrevista e observação orientada. Veri cou-se que, de forma geral, os serviços prestados estão dentro de um padrão aceitável pelos clientes, porém há falta de espaço apropriado para a realização de um evento nesse ambiente. Palavras-chave: Motel. Eventos em Motel. Hospedagem alternativa.
MICROCERVEJARIAS CATARINENSES E O TURISMO: da formação de tipologias do produto às aproximações com a atividade
Authors: Eltermann Eddy Ervin , De Matos Ângela Maria , Da Silva Dávila Araújo
Published: September 2016

A proposta deste artigo é estimular a discussão em torno da potencialidade turística concebida pelas microcervejarias catarinenses. Analisa-se aqui o ‘produto turístico’ com o enfoque na categorização da produção que se forma através do estabelecimento de marcos que caracterizem a concepção artesanal desta bebida. Emprega- se aqui o materialismo histórico dialético como ferramenta de pesquisa, seja na construção de um novo ideário sobre o tema ‘consumo de cerveja’, seja na compreensão histórica desse elemento ou na proposta de incorporação do consumo consciente de bebidas alcóolicas como elemento de lazer na sociedade, estando este, inserido no turismo. Nesse sentido, busca-se reconhecer a tipologia da produção catarinense para com base no Beer Judge Certi cation Program (BJCP) para que este reconhecimento possa servir como facilitador do turismo gastronômico em microcervejarias.Palavras-chave: Microcervejarias; Beer Judge Certi cation Program (BJCP); Turismo Cervejeiro Catarinense.
Judicial tyranny or American justice? How partisan news’ coverage of polarizing Supreme Court decisions differs in framing the nation’s highest court
Authors: Matthias Lisa
Published: September 2016

The U.S. Supreme Court is isolated from the public, yet dependent on high levels of public support to maintain its legitimacy. Due to its distance, the media has great control over how the nation’s highest court is presented to the public. Partisan news outlets cater their stories to audiences with distinct ideological beliefs, reinforcing them while opposing opposite beliefs. This can lead to partisan polarization, which has previously been exclusive to the political realm. However, recent polls have revealed an existing party gap in the Supreme Court’s level of public support, which implies a politicization of the judiciary branch. When the Supreme Court appears to be just another political institution or simply an extension of the other two governmental branches, its integrity is greatly impaired, and, as a consequence, the public’s confidence in the Justices is likely to deteriorate. This study analyzes Fox News’ and MSNBC’s news coverage of two pollogical stance aligns with the Court’s decision, the Supreme Court is presented as an apolitical institution, whereas it is politicized when the decision is contrary the channel’s partisan stance. This implies that the partisan divide, once only common to the political realm has now reached the judiciary.
Assessing Public Health Majors through the Use of e-Portfolios
Authors: Crowell Tara L. , Calamidas Elizabeth
Published: September 2016

When assessing an entire academic program, there are various possibilities; most require students to reflect holistically on knowledge learned. Final presentations, internships, theses, and dissertations all require the students to recall the entirety of their learning experience. These are more traditional ways to assess the student as well as the program as a whole. However, with advancement in technology, the use of electronic portfolios (e-Portfolios) has been advocated to highlight student accomplishments as well as to document program and course outcomes. The following project illustrates the use of e-portfolios and develops specific rubrics in order to measure both student learning and program assessment. The use of e-Portfolios as an assessment measure was developed and implemented into the Public Health Program. All graduating students, upon completing their internships, create an ePortfolio. These portfolios are used by faculty for both student and program assessment purposes. Data collected over the 7 semesters provides valuable insight into both students’ level of competencies and program outcomes for both Pubic Health core goals and objectives.
Análise dos benefícios de um espaço logístico urbano na distribuição urbana de mercadorias
Authors: Oliveira Leise Kelli de , Henriques Rafaella de Souza , Oliveira Raissa Simonetti de , Denais Martin
Published: September 2016

O transporte urbano de mercadorias é responsável por atender a cadeia de consumo das cidades, sendo essencial no desenvolvimento destas, apesar dos conflitos e problemas advindos da atividade. Nesse contexto, este trabalho apresenta uma análise da implantação de Espaços Logísticos Urbanos como centros de distribuição intermediários no transporte de mercadorias em áreas urbanas, utilizando veículos de cargas e triciclos elétricos para reduzir os impactos negativos da distribuição urbana de mercadorias. Para tanto, uma rede de transporte para a região central da cidade de Belo Horizonte foi desenvolvida e, utilizando-se das ferramentas de localização e roteamento do TransCAD®, obteve-se a localização do Espaço Logístico Urbano e as rotas de entrega entre o centro de distribuição, este espaço e o cliente final. Os resultados da análise indicam que os custos de operação, a quilometragem percorrida, número de veículos e emissão de poluentes são reduzidos com a implantação de um Espaço Logístico Urbano, com benefícios para a mobilidade urbana.
Lean office e BPM: proposição e aplicação de método para a redução de desperdícios em áreas administrativas
Authors: Girardi Tegner Mateus , Nascimento de Lima Pedro , Veit Douglas Rafael , Corcini Neto Secundino Luis Henrique
Published: September 2016

A necessidade de eliminar desperdícios em áreas administrativas amplifica-se à medida que aumenta a competitividade nos setores, pressionando assim a redução de custos e despesas fixas. Neste contexto, além de mostrarem-se relevantes para as operações diretas, os conceitos e ferramentas Lean também ganham importância no escritório e em áreas de apoio. Apesar disto, os métodos disponíveis para a utilização do Lean em áreas administrativas carecem de integração com técnicas consolidadas pela literatura em Gerenciamento de Processos de Negócio. Frente a necessidade das organizações em eliminar desperdícios, e às lacunas identificadas na literatura existente sobre Lean Office, o presente artigo apresenta a proposição de um método para a implantação do Lean em áreas administrativas, incorporando o uso de técnicas de Gerenciamento de Processos. Além disto, este trabalho apresenta a aplicação do método no Sindicato das Indústrias Metalúrgica, Mecânica e de Material Elétrico e Eletrônico de São Leopoldo - SINDIMETAL. Para este objetivo, o trabalho revisa os conceitos Lean e de Gerenciamento de Processos de Negócio, utilizando como método de pesquisa a Design Science Research. Por fim são discutidas implicações a partir destas proposições bem como perspectivas para o desenvolvimento do Lean como alternativa para melhoria em operações administrativas.